A0A0G2K344 CHOYP_PK3CA.1.1 m.65093 sp PK3CA_RAT 54.571 1061 463 11 3 1046 5 1063 0 1184 PK3CA_RAT reviewed "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)" Pik3ca Rattus norvegicus (Rat) 1068 angiogenesis [GO:0001525]; phagocytosis [GO:0006909]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphatidylinositol phosphorylation [GO:0046854]; response to butyrate [GO:1903544]; response to dexamethasone [GO:0071548]; response to leucine [GO:0043201]; response to muscle inactivity [GO:0014870] GO:0001525; GO:0004674; GO:0005524; GO:0005829; GO:0005942; GO:0006909; GO:0014870; GO:0016303; GO:0043201; GO:0046854; GO:0046934; GO:0048015; GO:0071548; GO:1903544 0 0 0 PF00454;PF00792;PF02192;PF00794;PF00613; A0A0R4IBK5 CHOYP_LOC100030710.2.4 m.13432 sp R213A_DANRE 35.855 3542 2013 84 832 4287 1807 5175 0 1998 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_LOC100030710.4.4 m.20819 sp R213A_DANRE 33.133 3984 2214 115 502 4320 243 3941 0 1834 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RN213.1.13 m.524 sp R213A_DANRE 33.422 4518 2602 107 15 4420 975 5198 0 2254 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RN213.12.13 m.60577 sp R213A_DANRE 29.606 5259 3093 163 90 5118 180 5059 0 1961 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RN213.2.13 m.3944 sp R213A_DANRE 27.491 2328 1470 62 3 2252 2988 5175 0 775 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RN213.4.13 m.27716 sp R213A_DANRE 35.861 3561 2031 85 1074 4554 1811 5198 0 2004 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RN213.6.13 m.42268 sp R213A_DANRE 40.589 2173 1123 51 2132 4251 1811 3868 0 1506 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RN213.7.13 m.45975 sp R213A_DANRE 46.528 1541 717 34 2150 3652 1811 3282 0 1314 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RN213.9.13 m.52892 sp R213A_DANRE 39.152 1839 967 38 8 1827 1373 3078 0 1221 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RNF213.1.4 m.3458 sp R213A_DANRE 31.874 4775 2722 135 290 4869 142 4580 0 2094 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0A0R4IBK5 CHOYP_RNF213.3.4 m.13881 sp R213A_DANRE 29.089 5380 3185 158 57 5181 143 5147 0 1993 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0AVT1 CHOYP_UBA6.4.4 m.63770 sp UBA6_HUMAN 54.624 811 362 5 9 818 146 951 0 920 UBA6_HUMAN reviewed Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) UBA6 MOP4 UBE1L2 Homo sapiens (Human) 1052 amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004839; GO:0005524; GO:0005737; GO:0005829; GO:0006511; GO:0007612; GO:0007626; GO:0016567; GO:0019780; GO:0021764; GO:0021766; GO:0042787; GO:0060996 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P22314}. 0 0 PF16191;PF16190;PF09358;PF00899;PF10585; A0JM12 CHOYP_LOC100867487.2.2 m.65146 sp MEG10_XENTR 35.401 1096 658 15 4 1080 5 1069 0 630 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A0JM12 CHOYP_LOC100875026.1.2 m.40822 sp MEG10_XENTR 43.325 764 422 5 6 764 3 760 0 608 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A0JM12 CHOYP_LOC100875026.2.2 m.54201 sp MEG10_XENTR 43.211 766 427 4 1 764 1 760 0 617 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A0JM23 CHOYP_NPHP3.1.1 m.722 sp NPHP3_XENTR 45.543 1335 665 24 1 1307 1 1301 0 1052 NPHP3_XENTR reviewed Nephrocystin-3 nphp3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1311 "cilium morphogenesis [GO:0060271]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; Wnt signaling pathway [GO:0016055]" GO:0005929; GO:0016055; GO:0060271; GO:0072372; GO:0090090; GO:2000095 0 0 0 PF13176; A0JM56 CHOYP_LOC578913.1.1 m.51577 sp LRRC9_XENTR 46.034 1475 715 21 50 1471 10 1456 0 1185 LRRC9_XENTR reviewed Leucine-rich repeat-containing protein 9 lrrc9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1502 0 0 0 0 0 PF13855; A0JMA9 CHOYP_KATL2.1.2 m.48835 sp KATL2_XENTR 58.974 585 175 13 35 598 2 542 0 644 KATL2_XENTR reviewed Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 542 cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013] GO:0005524; GO:0005634; GO:0005737; GO:0005874; GO:0008568; GO:0031122; GO:0051013 0 0 0 PF00004;PF08513; A0JMA9 CHOYP_KATL2.2.2 m.56279 sp KATL2_XENTR 56.364 605 188 13 28 620 2 542 0 631 KATL2_XENTR reviewed Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 3.6.4.3) (p60 katanin-like 2) katnal2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 542 cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013] GO:0005524; GO:0005634; GO:0005737; GO:0005874; GO:0008568; GO:0031122; GO:0051013 0 0 0 PF00004;PF08513; A0JMD4 CHOYP_TPC2.1.2 m.19378 sp TPC2_DANRE 43.179 755 370 13 31 765 58 773 0 578 TPC2_DANRE reviewed Two pore calcium channel protein 2 (Voltage-dependent calcium channel protein TPC2) tpcn2 tpc2 zgc:152898 Danio rerio (Zebrafish) (Brachydanio rerio) 774 membrane depolarization during action potential [GO:0086010]; smooth muscle contraction [GO:0006939] GO:0005245; GO:0005764; GO:0005765; GO:0005886; GO:0006939; GO:0016021; GO:0072345; GO:0086010 0 0 0 PF00520; A0JMQ0 CHOYP_BOP1.1.1 m.66373 sp BOP1_DANRE 62.154 650 230 7 141 788 142 777 0 884 BOP1_DANRE reviewed Ribosome biogenesis protein bop1 (Block of proliferation 1 protein) bop1 si:ch211-251g8.4 Danio rerio (Zebrafish) (Brachydanio rerio) 777 "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]" GO:0000463; GO:0000466; GO:0005654; GO:0030687; GO:0043021; GO:0051726; GO:0070545 0 0 0 PF08145;PF00400; A0JMY5 CHOYP_NFXL1.1.1 m.9381 sp NFXL1_XENLA 46.939 882 444 13 2 869 38 909 0 755 NFXL1_XENLA reviewed NF-X1-type zinc finger protein NFXL1 nfxl1 Xenopus laevis (African clawed frog) 914 0 GO:0003700; GO:0005634; GO:0008270; GO:0016021 0 0 0 PF01422; A0JN80 CHOYP_DI3L1.1.1 m.16400 sp DI3L1_BOVIN 51.838 1061 473 16 7 1048 2 1043 0 1098 DI3L1_BOVIN reviewed DIS3-like exonuclease 1 (EC 3.1.13.-) DIS3L Bos taurus (Bovine) 1053 mRNA catabolic process [GO:0006402]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364] GO:0000175; GO:0000176; GO:0000177; GO:0003723; GO:0006364; GO:0006402; GO:0016075 0 0 0 0 A0JNG7 CHOYP_F16B1.1.1 m.39200 sp F16B1_BOVIN 44.358 771 381 10 5 737 1 761 0 648 F16B1_BOVIN reviewed Protein FAM160B1 FAM160B1 Bos taurus (Bovine) 765 0 0 0 0 0 PF10257; A0JP70 CHOYP_LOC100371299.1.1 m.8007 sp WDR90_XENTR 46.025 1912 934 25 1 1881 1 1845 0 1727 WDR90_XENTR reviewed WD repeat-containing protein 90 wdr90 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1848 0 0 0 0 0 PF05018;PF00400; A0JPE9 CHOYP_BRAFLDRAFT_278567.1.1 m.18108 sp GLPK5_DANRE 50.688 509 245 2 42 545 1 508 0 559 GLPK5_DANRE reviewed Putative glycerol kinase 5 (GK 5) (Glycerokinase 5) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase 5) gk5 zgc:152983 Danio rerio (Zebrafish) (Brachydanio rerio) 510 glycerol catabolic process [GO:0019563]; phosphorylation [GO:0016310] GO:0004370; GO:0005524; GO:0005737; GO:0016310; GO:0016773; GO:0019563 PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. 0 0 PF02782;PF00370; A0JPH4 CHOYP_BRAFLDRAFT_118545.2.2 m.54585 sp SCAP_XENLA 35.391 1458 714 33 1 1379 3 1311 0 800 SCAP_XENLA reviewed Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) scap Xenopus laevis (African clawed frog) 1311 cholesterol metabolic process [GO:0008203]; SREBP signaling pathway [GO:0032933] GO:0000139; GO:0005789; GO:0008203; GO:0012507; GO:0015485; GO:0016021; GO:0032933 0 0 0 PF12349;PF00400; A0M8U1 CHOYP_ST7.1.1 m.41853 sp ST7_CHICK 74.074 567 128 4 15 581 7 554 0 848 ST7_CHICK reviewed Suppressor of tumorigenicity 7 protein homolog ST7 Gallus gallus (Chicken) 554 0 GO:0016021 0 0 0 PF04184; A1A4R8 CHOYP_CDC23.1.1 m.6463 sp CDC23_BOVIN 58.087 575 220 8 14 572 28 597 0 655 CDC23_BOVIN reviewed Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8) CDC23 ANAPC8 Bos taurus (Bovine) 597 cell division [GO:0051301]; mitotic metaphase plate congression [GO:0007080]; protein K11-linked ubiquitination [GO:0070979]; regulation of mitotic metaphase/anaphase transition [GO:0030071] GO:0005680; GO:0007080; GO:0030071; GO:0051301; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF04049;PF13414;PF13181; A1A4S6 CHOYP_LOC100749296.1.1 m.45471 sp RHG10_HUMAN 43.981 839 396 18 37 854 1 786 0 610 RHG10_HUMAN reviewed Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) ARHGAP10 GRAF2 Homo sapiens (Human) 786 cytoskeleton organization [GO:0007010]; negative regulation of apoptotic process [GO:0043066]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0005886; GO:0007010; GO:0007165; GO:0043066; GO:0048471; GO:0051056 0 0 0 PF00169;PF00620;PF14604; A1A5F2 CHOYP_HTR5B.1.1 m.39330 sp HTR5B_XENTR 55.727 2078 850 15 1 2035 1 2051 0 2274 HTR5B_XENTR reviewed HEAT repeat-containing protein 5B heatr5b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 2052 0 0 0 0 0 0 A1A5G0 CHOYP_CLAP1.2.6 m.31155 sp CLAP1_XENTR 47.46 807 323 19 96 830 659 1436 0 657 CLAP1_XENTR reviewed CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) clasp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1452 cell division [GO:0051301]; microtubule anchoring [GO:0034453]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005794; GO:0005815; GO:0005828; GO:0005881; GO:0007020; GO:0007067; GO:0031023; GO:0034453; GO:0051301 0 0 0 PF12348; A1A5G0 CHOYP_CLAP1.3.6 m.35558 sp CLAP1_XENTR 44.005 1493 644 30 2 1361 3 1436 0 1116 CLAP1_XENTR reviewed CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) clasp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1452 cell division [GO:0051301]; microtubule anchoring [GO:0034453]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005794; GO:0005815; GO:0005828; GO:0005881; GO:0007020; GO:0007067; GO:0031023; GO:0034453; GO:0051301 0 0 0 PF12348; A1A5G0 CHOYP_CLAP1.4.6 m.39950 sp CLAP1_XENTR 44.602 1482 665 29 2 1375 3 1436 0 1134 CLAP1_XENTR reviewed CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) clasp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1452 cell division [GO:0051301]; microtubule anchoring [GO:0034453]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005794; GO:0005815; GO:0005828; GO:0005881; GO:0007020; GO:0007067; GO:0031023; GO:0034453; GO:0051301 0 0 0 PF12348; A1A5G0 CHOYP_CLAP1.5.6 m.45250 sp CLAP1_XENTR 44.748 1466 642 30 3 1344 15 1436 0 1133 CLAP1_XENTR reviewed CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) clasp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1452 cell division [GO:0051301]; microtubule anchoring [GO:0034453]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005794; GO:0005815; GO:0005828; GO:0005881; GO:0007020; GO:0007067; GO:0031023; GO:0034453; GO:0051301 0 0 0 PF12348; A1A5G0 CHOYP_RENT1.1.1 m.44134 sp CLAP1_XENTR 47.396 768 306 17 3 706 703 1436 0 637 CLAP1_XENTR reviewed CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) clasp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1452 cell division [GO:0051301]; microtubule anchoring [GO:0034453]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005794; GO:0005815; GO:0005828; GO:0005881; GO:0007020; GO:0007067; GO:0031023; GO:0034453; GO:0051301 0 0 0 PF12348; A1A5Q4 CHOYP_LOC100369566.1.1 m.41492 sp CF206_RAT 63.738 626 221 4 25 648 1 622 0 826 CF206_RAT reviewed Cilia- and flagella-associated protein 206 Cfap206 Rattus norvegicus (Rat) 622 0 0 0 0 0 PF12018; A1A5S1 CHOYP_PRP6.1.2 m.28600 sp PRP6_RAT 74.466 936 219 5 7 924 1 934 0 1417 PRP6_RAT reviewed Pre-mRNA-processing factor 6 (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) Prpf6 Rattus norvegicus (Rat) 941 positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; RNA localization [GO:0006403]; spliceosomal tri-snRNP complex assembly [GO:0000244] GO:0000244; GO:0003713; GO:0005682; GO:0006403; GO:0016020; GO:0016607; GO:0043021; GO:0044822; GO:0045944; GO:0046540; GO:0071013 0 0 0 PF06424; A1L0Y2 CHOYP_NEUL4.1.2 m.15390 sp NEUL4_XENTR 51.253 718 282 14 1 664 408 1111 0 666 NEUL4_XENTR reviewed Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1477 0 GO:0005814 0 0 0 PF07177; A1L0Y2 CHOYP_NEUL4.2.2 m.54340 sp NEUL4_XENTR 49.967 1503 656 23 16 1450 3 1477 0 1444 NEUL4_XENTR reviewed Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1477 0 GO:0005814 0 0 0 PF07177; A1L252 CHOYP_RANB9.1.2 m.40766 sp RANB9_DANRE 60.063 631 187 11 12 631 21 597 0 750 RANB9_DANRE reviewed Ran-binding protein 9 (RanBP9) ranbp9 zgc:158650 Danio rerio (Zebrafish) (Brachydanio rerio) 597 0 GO:0005634; GO:0005737 0 0 0 PF10607;PF08513;PF00622; A1L252 CHOYP_RANB9.2.2 m.61564 sp RANB9_DANRE 62.438 607 187 10 12 607 21 597 0 763 RANB9_DANRE reviewed Ran-binding protein 9 (RanBP9) ranbp9 zgc:158650 Danio rerio (Zebrafish) (Brachydanio rerio) 597 0 GO:0005634; GO:0005737 0 0 0 PF10607;PF08513;PF00622; A1L258 CHOYP_LOC100367659.1.1 m.9232 sp D2HDH_DANRE 63.147 464 169 1 39 500 67 530 0 623 D2HDH_DANRE reviewed "D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.-)" d2hgdh zgc:158661 Danio rerio (Zebrafish) (Brachydanio rerio) 533 0 GO:0005739; GO:0016614; GO:0050660 0 0 0 PF02913;PF01565; A1Z7T0 CHOYP_LOC582022.1.1 m.31 sp PKN_DROME 80.48 333 65 0 378 710 858 1190 0 575 PKN_DROME reviewed Serine/threonine-protein kinase N (EC 2.7.11.13) (Protein kinase related to PKN) Pkn Dpkn CG2049 Drosophila melanogaster (Fruit fly) 1190 "actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; dorsal closure [GO:0007391]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of wound healing [GO:0090303]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; wing disc morphogenesis [GO:0007472]" GO:0004672; GO:0004674; GO:0004697; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0006351; GO:0006355; GO:0006468; GO:0007049; GO:0007155; GO:0007391; GO:0007472; GO:0016020; GO:0018105; GO:0030027; GO:0030054; GO:0030496; GO:0031532; GO:0032154; GO:0035556; GO:0046777; GO:0051301; GO:0090303 0 0 0 PF02185;PF00069;PF00433; A2A9C3 CHOYP_SZT2.1.1 m.34390 sp SZT2_MOUSE 32.711 1874 1064 51 15 1796 13 1781 0 853 SZT2_MOUSE reviewed Protein SZT2 (Seizure threshold 2 protein) (Transcript increased in glutamate resistance) (TIGR) Szt2 Mus musculus (Mouse) 3431 central nervous system development [GO:0007417]; corpus callosum morphogenesis [GO:0021540]; pigmentation [GO:0043473]; post-embryonic development [GO:0009791]; regulation of superoxide dismutase activity [GO:1901668] GO:0005777; GO:0007417; GO:0009791; GO:0021540; GO:0043473; GO:0070062; GO:1901668 0 0 0 0 A2AAE1 CHOYP_K1109.1.1 m.1088 sp K1109_MOUSE 39.772 1755 800 52 1 1587 3327 4992 0 1029 K1109_MOUSE reviewed Uncharacterized protein KIAA1109 (Fragile site-associated protein homolog) Kiaa1109 Fsa Kiaa1371 Mus musculus (Mouse) 5005 adipose tissue development [GO:0060612]; fat cell differentiation [GO:0045444]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; nucleus localization [GO:0051647]; regulation of cell growth [GO:0001558]; spermatogenesis [GO:0007283] GO:0001558; GO:0005634; GO:0006629; GO:0007283; GO:0016021; GO:0019915; GO:0045444; GO:0051647; GO:0060612 0 0 0 PF10479; A2AAE1 CHOYP_LOC100166052.1.1 m.46867 sp K1109_MOUSE 38.486 2523 1184 76 1511 3854 2659 4992 0 1452 K1109_MOUSE reviewed Uncharacterized protein KIAA1109 (Fragile site-associated protein homolog) Kiaa1109 Fsa Kiaa1371 Mus musculus (Mouse) 5005 adipose tissue development [GO:0060612]; fat cell differentiation [GO:0045444]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; nucleus localization [GO:0051647]; regulation of cell growth [GO:0001558]; spermatogenesis [GO:0007283] GO:0001558; GO:0005634; GO:0006629; GO:0007283; GO:0016021; GO:0019915; GO:0045444; GO:0051647; GO:0060612 0 0 0 PF10479; A2AAE1 CHOYP_LOC100748709.1.1 m.44005 sp K1109_MOUSE 40.418 1101 593 18 1 1043 80 1175 0 847 K1109_MOUSE reviewed Uncharacterized protein KIAA1109 (Fragile site-associated protein homolog) Kiaa1109 Fsa Kiaa1371 Mus musculus (Mouse) 5005 adipose tissue development [GO:0060612]; fat cell differentiation [GO:0045444]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; nucleus localization [GO:0051647]; regulation of cell growth [GO:0001558]; spermatogenesis [GO:0007283] GO:0001558; GO:0005634; GO:0006629; GO:0007283; GO:0016021; GO:0019915; GO:0045444; GO:0051647; GO:0060612 0 0 0 PF10479; A2AHL1 CHOYP_TMEM16.2.2 m.41752 sp ANO3_MOUSE 46.049 658 324 10 103 748 131 769 0 583 ANO3_MOUSE reviewed Anoctamin-3 (Transmembrane protein 16C) Ano3 Tmem16c Mus musculus (Mouse) 981 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; detection of mechanical stimulus [GO:0050982]; detection of temperature stimulus [GO:0016048] GO:0005886; GO:0016021; GO:0016048; GO:0017128; GO:0050982; GO:0061590; GO:0061591 0 0 0 PF16178;PF04547; A2AJ88 CHOYP_LOC100698638.1.1 m.45171 sp PLPL7_MOUSE 51.124 1334 571 20 35 1320 34 1334 0 1289 PLPL7_MOUSE reviewed Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (Neuropathy target esterase-related esterase) (NRE) (NTE-related esterase) Pnpla7 Mus musculus (Mouse) 1352 developmental process [GO:0032502]; glycerophospholipid catabolic process [GO:0046475] GO:0004622; GO:0005765; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0031966; GO:0032502; GO:0046475 0 0 0 PF00027;PF01734; A2AJL3 CHOYP_FGGY.1.1 m.41559 sp FGGY_MOUSE 51.964 560 244 8 5 560 13 551 0 575 FGGY_MOUSE reviewed FGGY carbohydrate kinase domain-containing protein (EC 2.7.1.-) Fggy Mus musculus (Mouse) 552 carbohydrate metabolic process [GO:0005975]; neuron cellular homeostasis [GO:0070050]; phosphorylation [GO:0016310] GO:0005737; GO:0005975; GO:0016301; GO:0016310; GO:0016773; GO:0070050 0 0 cd07782; PF02782;PF00370; A2ASS6 CHOYP_LOC100367089.1.4 m.1385 sp TITIN_MOUSE 29.624 1438 970 17 2333 3750 14048 15463 0 641 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A2ASS6 CHOYP_LOC100367089.3.4 m.39678 sp TITIN_MOUSE 30.232 2547 1534 72 2 2452 23412 25811 0 939 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A2ASS6 CHOYP_TITIN.8.19 m.35861 sp TITIN_MOUSE 31.937 1910 1126 51 8725 10554 23996 25811 0 798 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A2AV36 CHOYP_LOC100867962.1.1 m.19193 sp ANM7_DANRE 41.46 685 391 7 15 696 1 678 0 577 ANM7_DANRE reviewed Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) prmt7 ch211-51l3.2 Danio rerio (Zebrafish) (Brachydanio rerio) 683 "cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; histone arginine methylation [GO:0034969]; peptidyl-arginine methylation [GO:0018216]; peptidyl-arginine methylation, to symmetrical-dimethyl arginine [GO:0019918]; regulation of gene expression by genetic imprinting [GO:0006349]; regulation of transcription, DNA-templated [GO:0006355]; spliceosomal snRNP assembly [GO:0000387]; transcription, DNA-templated [GO:0006351]" GO:0000387; GO:0005634; GO:0005829; GO:0006349; GO:0006351; GO:0006355; GO:0008469; GO:0008757; GO:0018216; GO:0019918; GO:0030154; GO:0034969; GO:0035241; GO:0035242; GO:0035243; GO:0043046; GO:0044020 0 0 0 0 A2AWA9 CHOYP_RABGAP1.1.1 m.50532 sp RBGP1_MOUSE 57.652 954 375 13 86 1026 120 1057 0 1040 RBGP1_MOUSE reviewed Rab GTPase-activating protein 1 (GAP and centrosome-associated protein) (Rab6 GTPase-activating protein GAPCenA) Rabgap1 Kiaa4104 Mus musculus (Mouse) 1064 activation of GTPase activity [GO:0090630]; cell cycle [GO:0007049]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0005815; GO:0005829; GO:0006886; GO:0007049; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF12473;PF00640;PF00566; A2BGR3 CHOYP_LOC100373376.1.1 m.17615 sp ERC6L_DANRE 55.479 721 300 10 536 1240 15 730 0 823 ERC6L_DANRE reviewed DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) ercc6l si:ch211-278b8.3 Danio rerio (Zebrafish) (Brachydanio rerio) 1451 cell division [GO:0051301]; intein-mediated protein splicing [GO:0016539]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0003677; GO:0004386; GO:0005524; GO:0007067; GO:0016539; GO:0051301 0 0 0 PF00271;PF00176; A2BHJ4 CHOYP_LOC100122037.1.1 m.12516 sp CNO6L_DANRE 59.489 548 194 7 1 536 1 532 0 670 CNO6L_DANRE reviewed CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) cnot6l si:dkey-58f10.2 zgc:111987 Danio rerio (Zebrafish) (Brachydanio rerio) 559 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0004535; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006397; GO:0006417; GO:0030014; GO:0031047; GO:0046872 0 0 0 PF03372;PF13855; A2CEA7 CHOYP_LOC574811.1.2 m.36266 sp RGRF2_DANRE 54.301 744 273 15 1 736 1 685 0 763 RGRF2_DANRE reviewed Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2) rasgrf2 si:ch211-194b21.1 si:dkey-56d12.3 Danio rerio (Zebrafish) (Brachydanio rerio) 1244 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264] GO:0005089; GO:0005789; GO:0005886; GO:0007264; GO:0035023 0 0 cd06224; PF00169;PF00617;PF00618;PF00621; A2CEI6 CHOYP_LOC583253.1.1 m.11773 sp PIWL2_DANRE 42.05 956 506 16 9 938 113 1046 0 783 PIWL2_DANRE reviewed Piwi-like protein 2 piwil2 zili si:dkey-88f5.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1046 DNA methylation involved in gamete generation [GO:0043046]; gamete generation [GO:0007276]; gene silencing by RNA [GO:0031047]; germ-line stem cell population maintenance [GO:0030718]; meiotic nuclear division [GO:0007126]; multicellular organism development [GO:0007275]; negative regulation of SMAD protein complex assembly [GO:0010991]; oogenesis [GO:0048477]; piRNA metabolic process [GO:0034587]; positive regulation of gene expression [GO:0010628]; regulation of translation [GO:0006417]; RNA 5'-end processing [GO:0000966] GO:0000966; GO:0005634; GO:0005737; GO:0006417; GO:0007126; GO:0007275; GO:0007276; GO:0010628; GO:0010991; GO:0030718; GO:0031047; GO:0034584; GO:0034587; GO:0043046; GO:0043186; GO:0048477; GO:0071546; GO:1990923 0 0 0 PF08699;PF02170;PF02171; A2RSY1 CHOYP_LOC100726123.1.1 m.17932 sp KANL3_MOUSE 56.842 475 189 7 1 470 32 495 0 577 KANL3_MOUSE reviewed KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) Kansl3 Kiaa1310 Nsl3 Mus musculus (Mouse) 903 histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982] GO:0000123; GO:0005634; GO:0005654; GO:0005730; GO:0043231; GO:0043981; GO:0043982; GO:0043984; GO:0043995; GO:0043996; GO:0046972 0 0 0 0 A2RUV5 CHOYP_HFM1.1.1 m.46142 sp HFM1_XENTR 52.69 985 420 15 200 1160 135 1097 0 1040 HFM1_XENTR reviewed Probable ATP-dependent DNA helicase HFM1 (EC 3.6.4.12) hfm1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1336 meiotic cell cycle [GO:0051321] GO:0003676; GO:0004386; GO:0005524; GO:0051321 0 0 0 PF00270;PF00271;PF02889; A3KMX0 CHOYP_LOC100014225.1.1 m.18918 sp ER6L2_BOVIN 50.314 636 302 6 241 873 96 720 0 660 ER6L2_BOVIN reviewed DNA excision repair protein ERCC-6-like 2 (EC 3.6.4.-) ERCC6L2 Bos taurus (Bovine) 1558 DNA repair [GO:0006281] GO:0003677; GO:0005524; GO:0005634; GO:0005739; GO:0005815; GO:0006281; GO:0008026 0 0 0 PF00271;PF00176;PF14773; A3KN83 CHOYP_SBNO1.1.1 m.7257 sp SBNO1_HUMAN 63.436 1228 399 16 359 1564 188 1387 0 1518 SBNO1_HUMAN reviewed Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3) SBNO1 MOP3 Homo sapiens (Human) 1393 "regulation of transcription, DNA-templated [GO:0006355]" GO:0006355 0 0 0 PF13871; A4IF62 CHOYP_RPC1.1.1 m.16567 sp RPC1_BOVIN 72.682 1391 372 7 1 1387 1 1387 0 2138 RPC1_BOVIN reviewed DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A) POLR3A Bos taurus (Bovine) 1390 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003677; GO:0003682; GO:0003899; GO:0005666; GO:0006383; GO:0016020; GO:0032728; GO:0045087; GO:0046872; GO:0051607; GO:1903146; GO:1903955 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998; A4IF63 CHOYP_BRAFLDRAFT_69647.1.5 m.10272 sp TRIM2_BOVIN 51.163 774 333 6 38 806 11 744 0 816 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IGL7 CHOYP_PXDN.1.5 m.11038 sp PXDN_XENTR 44.262 1464 761 21 3 1432 7 1449 0 1273 PXDN_XENTR reviewed Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1457 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF03098;PF07679;PF13855;PF00093; A4IHD2 CHOYP_ARIP4.3.3 m.33366 sp ARIP4_XENTR 49.021 1175 462 28 77 1178 40 1150 0 1062 ARIP4_XENTR reviewed Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) rad54l2 arip4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1396 0 GO:0003677; GO:0004386; GO:0005524; GO:0005634 0 0 0 PF00271;PF00176; A4II09 CHOYP_UBP47.2.2 m.66754 sp EIF3A_XENTR 52.696 1298 500 33 1 1231 1 1251 0 1066 EIF3A_XENTR reviewed Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) eif3a eif3s10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1391 formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446] GO:0001731; GO:0001732; GO:0003743; GO:0005852; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF01399; A4Q9F6 CHOYP_BRAFLDRAFT_126017.1.1 m.55964 sp TTL13_MOUSE 60.074 541 200 5 130 664 90 620 0 671 TTL13_MOUSE reviewed Tubulin polyglutamylase TTLL13 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 13) Ttll13 Mus musculus (Mouse) 804 cellular protein modification process [GO:0006464] GO:0005524; GO:0005874; GO:0006464; GO:0016874 0 0 0 PF03133; A4Q9F6 CHOYP_LOC100371480.3.3 m.64091 sp TTL13_MOUSE 60.074 541 200 5 130 664 90 620 0 671 TTL13_MOUSE reviewed Tubulin polyglutamylase TTLL13 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 13) Ttll13 Mus musculus (Mouse) 804 cellular protein modification process [GO:0006464] GO:0005524; GO:0005874; GO:0006464; GO:0016874 0 0 0 PF03133; A4Q9F6 CHOYP_contig_043064 m.49712 sp TTL13_MOUSE 60.074 541 200 5 75 609 90 620 0 669 TTL13_MOUSE reviewed Tubulin polyglutamylase TTLL13 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 13) Ttll13 Mus musculus (Mouse) 804 cellular protein modification process [GO:0006464] GO:0005524; GO:0005874; GO:0006464; GO:0016874 0 0 0 PF03133; A5A6H9 CHOYP_NEMVEDRAFT_V1G183894.1.1 m.55454 sp ODBA_PANTR 64.899 396 138 1 48 442 49 444 0 553 ODBA_PANTR reviewed "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)" BCKDHA Pan troglodytes (Chimpanzee) 445 0 GO:0003863; GO:0005759; GO:0046872 0 0 0 PF00676; A5D7C1 CHOYP_LOC100372046.1.1 m.7094 sp DDX52_BOVIN 50.943 583 250 6 2 548 1 583 0 605 DDX52_BOVIN reviewed Probable ATP-dependent RNA helicase DDX52 (EC 3.6.4.13) (DEAD box protein 52) DDX52 Bos taurus (Bovine) 596 RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364] GO:0004004; GO:0005524; GO:0005730; GO:0006364; GO:0010501; GO:0016020; GO:0044822 0 0 0 PF00270;PF00271; A5D7H2 CHOYP_STRN3.1.5 m.359 sp STRN3_BOVIN 57.368 760 252 7 36 744 59 797 0 840 STRN3_BOVIN reviewed Striatin-3 STRN3 Bos taurus (Bovine) 797 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000122; GO:0000159; GO:0003700; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0045892; GO:0045944 0 0 0 PF08232;PF00400; A5D7H2 CHOYP_STRN3.2.5 m.19731 sp STRN3_BOVIN 55.26 751 251 13 36 713 59 797 0 771 STRN3_BOVIN reviewed Striatin-3 STRN3 Bos taurus (Bovine) 797 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000122; GO:0000159; GO:0003700; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0045892; GO:0045944 0 0 0 PF08232;PF00400; A5D7H2 CHOYP_STRN3.3.5 m.25133 sp STRN3_BOVIN 58.995 756 265 10 36 763 59 797 0 855 STRN3_BOVIN reviewed Striatin-3 STRN3 Bos taurus (Bovine) 797 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000122; GO:0000159; GO:0003700; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0045892; GO:0045944 0 0 0 PF08232;PF00400; A5D7H2 CHOYP_STRN3.5.5 m.63982 sp STRN3_BOVIN 58.435 741 235 7 36 705 59 797 0 838 STRN3_BOVIN reviewed Striatin-3 STRN3 Bos taurus (Bovine) 797 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000122; GO:0000159; GO:0003700; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0045892; GO:0045944 0 0 0 PF08232;PF00400; A5GFN6 CHOYP_RAEL1.1.1 m.40419 sp RAEL1_PIG 74.124 371 84 5 1 362 1 368 0 564 RAEL1_PIG reviewed mRNA export factor (Rae1 protein homolog) (mRNA-associated protein mrnp 41) RAE1 MRNP41 Sus scrofa (Pig) 368 cellular response to organic cyclic compound [GO:0071407]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972] GO:0000972; GO:0003723; GO:0005643; GO:0005730; GO:0005737; GO:0006405; GO:0006606; GO:0043130; GO:0071407 0 0 0 PF00400; A5HK05 CHOYP_APBP2.1.1 m.62244 sp APBP2_RAT 63.071 547 200 1 3 547 2 548 0 723 APBP2_RAT reviewed Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) Appbp2 Rattus norvegicus (Rat) 585 intracellular transport [GO:0046907]; protein transport [GO:0015031] GO:0005634; GO:0005874; GO:0015031; GO:0030659; GO:0046907 0 0 0 PF13374; A5PK45 CHOYP_LOC100878123.1.1 m.55730 sp GT251_BOVIN 46.679 542 270 4 45 584 53 577 0 527 GT251_BOVIN reviewed Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1) COLGALT1 GLT25D1 Bos taurus (Bovine) 623 0 GO:0005788; GO:0016020; GO:0050211 0 0 cd06532; PF01755; A5PKG6 CHOYP_UBE4A.2.2 m.59113 sp UBE4A_BOVIN 42.561 1062 565 13 6 1033 9 1059 0 874 UBE4A_BOVIN reviewed Ubiquitin conjugation factor E4 A (EC 6.3.2.-) UBE4A Bos taurus (Bovine) 1067 protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000209; GO:0005737; GO:0006511; GO:0016874; GO:0034450 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:E9Q735}. 0 0 PF04564;PF10408; A5PKH3 CHOYP_FAAA.1.1 m.7653 sp FAAA_BOVIN 73.077 416 112 0 1 416 1 416 0 654 FAAA_BOVIN reviewed Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase) FAH Bos taurus (Bovine) 419 L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] GO:0004334; GO:0006559; GO:0006572; GO:0046872 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6. 0 0 PF01557;PF09298; A5YM72 CHOYP_CARNS1.1.6 m.2227 sp CRNS1_HUMAN 39.376 833 480 13 149 962 1 827 0 574 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A5YM72 CHOYP_CARNS1.5.6 m.63615 sp CRNS1_HUMAN 39.136 833 482 12 64 877 1 827 0 569 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A6H611 CHOYP_BRAFLDRAFT_277269.1.1 m.51636 sp MIPEP_MOUSE 47.299 685 355 4 10 692 21 701 0 662 MIPEP_MOUSE reviewed Mitochondrial intermediate peptidase (MIP) (EC 3.4.24.59) Mipep Mus musculus (Mouse) 711 peptide metabolic process [GO:0006518]; protein processing involved in protein targeting to mitochondrion [GO:0006627] GO:0004222; GO:0005739; GO:0005759; GO:0006518; GO:0006627; GO:0046872 0 0 0 PF01432; A6H8I2 CHOYP_LOC100116018.1.1 m.45080 sp SGSM3_XENLA 67.989 756 233 5 51 803 2 751 0 1103 SGSM3_XENLA reviewed Small G protein signaling modulator 3 homolog (RUN and TBC1 domain-containing protein 3) sgsm3 rutbc3 Xenopus laevis (African clawed frog) 753 0 0 0 0 0 PF00566;PF02759;PF00018; A6H8T7 CHOYP_LOC100372232.4.6 m.21072 sp CBPC2_DANRE 53.191 658 282 8 110 765 81 714 0 721 CBPC2_DANRE reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) (Testis-expressed protein 25) zte25 agbl2 ccp2 zgc:165648 Danio rerio (Zebrafish) (Brachydanio rerio) 721 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; A6N6J5 CHOYP_LOC100379049.1.1 m.51860 sp WDR35_RAT 69.521 1191 336 9 1 1186 1 1169 0 1751 WDR35_RAT reviewed WD repeat-containing protein 35 (Naofen) Wdr35 Rattus norvegicus (Rat) 1170 cilium assembly [GO:0042384]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512] GO:0005737; GO:0005813; GO:0005929; GO:0005930; GO:0030991; GO:0035091; GO:0035721; GO:0036064; GO:0042384; GO:0061512 0 0 0 PF12894; A6N6J5 CHOYP_LOC100379049.1.1 m.51861 sp WDR35_RAT 69.581 1121 322 7 1 1116 63 1169 0 1660 WDR35_RAT reviewed WD repeat-containing protein 35 (Naofen) Wdr35 Rattus norvegicus (Rat) 1170 cilium assembly [GO:0042384]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512] GO:0005737; GO:0005813; GO:0005929; GO:0005930; GO:0030991; GO:0035091; GO:0035721; GO:0036064; GO:0042384; GO:0061512 0 0 0 PF12894; A6NCI4 CHOYP_LOC592709.1.1 m.22553 sp VWA3A_HUMAN 42.263 1131 631 11 89 1216 63 1174 0 923 VWA3A_HUMAN reviewed von Willebrand factor A domain-containing protein 3A VWA3A Homo sapiens (Human) 1184 0 GO:0005576 0 0 0 PF13768; A6QLT2 CHOYP_LOC100313661.1.1 m.17706 sp MTMR2_BOVIN 63.089 615 217 4 24 638 35 639 0 851 MTMR2_BOVIN reviewed "Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)" MTMR2 Bos taurus (Bovine) 643 phosphatidylinositol dephosphorylation [GO:0046856] GO:0004438; GO:0004725; GO:0005829; GO:0031901; GO:0046856; GO:0052629 0 0 0 PF02893;PF06602; A6QLU1 CHOYP_LOC576660.1.1 m.33760 sp GPDM_BOVIN 62.908 674 239 5 53 716 55 727 0 890 GPDM_BOVIN reviewed "Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3)" GPD2 Bos taurus (Bovine) 727 camera-type eye development [GO:0043010]; gluconeogenesis [GO:0006094]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerol catabolic process [GO:0019563]; multicellular organism growth [GO:0035264] GO:0005509; GO:0005743; GO:0006072; GO:0006094; GO:0009331; GO:0019563; GO:0035264; GO:0043010; GO:0052591 PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1. 0 0 PF01266;PF16901;PF13499; A6QNM2 CHOYP_GFM2.1.1 m.18396 sp RRF2M_BOVIN 43.617 752 396 6 22 763 43 776 0 627 RRF2M_BOVIN reviewed "Ribosome-releasing factor 2, mitochondrial (RRF2mt) (Elongation factor G 2, mitochondrial) (EF-G2mt) (mEF-G 2)" GFM2 EFG2 Bos taurus (Bovine) 777 mitochondrial translation [GO:0032543]; ribosome disassembly [GO:0032790] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005739; GO:0032543; GO:0032790 0 0 0 PF00679;PF14492;PF03764;PF03144; A6QPU5 CHOYP_DARS2.1.1 m.43847 sp SYDM_BOVIN 49.604 631 293 12 37 646 5 631 0 615 SYDM_BOVIN reviewed "Aspartate--tRNA ligase, mitochondrial (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)" DARS2 Bos taurus (Bovine) 651 mitochondrial asparaginyl-tRNA aminoacylation [GO:0070145] GO:0003676; GO:0004815; GO:0005524; GO:0005759; GO:0070145 0 0 0 PF02938;PF00152;PF01336; A6QR56 CHOYP_BRAFLDRAFT_287353.1.1 m.46293 sp A16A1_BOVIN 41.141 824 445 11 38 850 6 800 0 616 A16A1_BOVIN reviewed Aldehyde dehydrogenase family 16 member A1 ALDH16A1 Bos taurus (Bovine) 800 0 GO:0019145; GO:0047105 0 0 0 PF00171; A7E305 CHOYP_ZSWM8.1.1 m.17640 sp ZSWM8_BOVIN 43.949 1099 515 29 822 1885 372 1404 0 755 ZSWM8_BOVIN reviewed Zinc finger SWIM domain-containing protein 8 ZSWIM8 Bos taurus (Bovine) 1413 0 GO:0008270 0 0 0 0 A7J1T0 CHOYP_LOC590385.1.1 m.33560 sp M313B_XENLA 43.518 995 401 34 35 953 52 961 0 629 M313B_XENLA reviewed Mitogen-activated protein kinase kinase kinase 13-B (EC 2.7.11.25) map3k13-b Xenopus laevis (African clawed frog) 961 JNK cascade [GO:0007254]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777] GO:0004709; GO:0005524; GO:0005737; GO:0007254; GO:0016020; GO:0046777; GO:0051092 0 0 0 PF07714; A7MAZ3 CHOYP_UBA5.1.2 m.8624 sp UBA5_BOVIN 71.464 403 103 5 3 395 4 404 0 582 UBA5_BOVIN reviewed Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) UBA5 UBE1DC1 Bos taurus (Bovine) 404 cyclic threonylcarbamoyladenosine biosynthetic process [GO:0061504]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976] GO:0005524; GO:0005634; GO:0005829; GO:0033146; GO:0034976; GO:0046872; GO:0061503; GO:0061504; GO:0071566; GO:0071569; GO:1990592 0 0 0 PF00899; A7RM45 CHOYP_LMBD1.2.2 m.33342 sp LMBD1_NEMVE 45.917 551 275 6 1 535 1 544 0 525 LMBD1_NEMVE reviewed Probable lysosomal cobalamin transporter v1g160387 Nematostella vectensis (Starlet sea anemone) 546 transport [GO:0006810] GO:0005765; GO:0006810; GO:0016021; GO:0031419 0 0 0 PF04791; A7RNG8 CHOYP_CCD22.1.1 m.6639 sp CCD22_NEMVE 53.033 643 290 7 4 638 1 639 0 691 CCD22_NEMVE reviewed Coiled-coil domain-containing protein 22 homolog v1g180167 Nematostella vectensis (Starlet sea anemone) 644 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060] GO:0097602; GO:2000060 0 0 0 0 A7RRJ0 CHOYP_FEN1.1.1 m.66181 sp FEN1_NEMVE 73.21 377 100 1 1 376 1 377 0 593 FEN1_NEMVE reviewed Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Flap structure-specific endonuclease 1) FEN1 v1g201054 Nematostella vectensis (Starlet sea anemone) 377 "base-excision repair [GO:0006284]; DNA replication, removal of RNA primer [GO:0043137]" GO:0000287; GO:0003677; GO:0005654; GO:0005730; GO:0005739; GO:0006284; GO:0008409; GO:0017108; GO:0043137 0 0 cd09867; PF00867;PF00752; A7SLX5 CHOYP_LOC100378925.1.1 m.26397 sp DPH1_NEMVE 65.321 421 128 4 36 443 40 455 0 571 DPH1_NEMVE reviewed Diphthamide biosynthesis protein 1 dph1 v1g246101 Nematostella vectensis (Starlet sea anemone) 465 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183] GO:0017183 PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. 0 0 PF01866; A7SMW7 CHOYP_PHUM_PHUM349810.1.2 m.7707 sp L2HDH_NEMVE 67.536 422 126 2 66 481 40 456 0 593 L2HDH_NEMVE reviewed "L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2)" v1g172254 Nematostella vectensis (Starlet sea anemone) 456 0 GO:0005739; GO:0047545 0 0 0 PF01266; A7SNN5 CHOYP_PLK4.1.1 m.28827 sp PLK4_NEMVE 41.188 1027 504 23 7 994 6 971 0 704 PLK4_NEMVE reviewed Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) v1g246408 Nematostella vectensis (Starlet sea anemone) 978 centriole replication [GO:0007099] GO:0004674; GO:0005524; GO:0005814; GO:0007099 0 0 cd13114;cd13115;cd13116; PF00069; A7SXZ6 CHOYP_OSGEP.1.1 m.29582 sp OSGEP_NEMVE 81.791 335 61 0 1 335 1 335 0 571 OSGEP_NEMVE reviewed Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep) (tRNA threonylcarbamoyladenosine biosynthesis protein osgep) osgep v1g194666 Nematostella vectensis (Starlet sea anemone) 335 tRNA threonylcarbamoyladenosine modification [GO:0002949] GO:0000408; GO:0002949; GO:0005634; GO:0005737; GO:0046872; GO:0061711 0 0 0 PF00814; A7Y2X0 CHOYP_LOC100375514.4.6 m.41109 sp SC6A5_XENLA 46.942 605 298 4 57 656 177 763 0 581 SC6A5_XENLA reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) 790 0 GO:0005328; GO:0005886; GO:0016021; GO:0046872 0 0 0 PF00209; A7Y2X0 CHOYP_LOC100375514.6.6 m.50450 sp SC6A5_XENLA 49.832 594 294 2 39 631 176 766 0 628 SC6A5_XENLA reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) 790 0 GO:0005328; GO:0005886; GO:0016021; GO:0046872 0 0 0 PF00209; A7Y2X0 CHOYP_SC6A5.6.7 m.53037 sp SC6A5_XENLA 45.441 669 341 8 105 766 108 759 0 604 SC6A5_XENLA reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) 790 0 GO:0005328; GO:0005886; GO:0016021; GO:0046872 0 0 0 PF00209; A7YWD2 CHOYP_IPO13.1.1 m.23515 sp IPO13_BOVIN 38.145 949 560 13 10 943 26 962 0 670 IPO13_BOVIN reviewed Importin-13 (Imp13) IPO13 Bos taurus (Bovine) 963 protein import into nucleus [GO:0006606] GO:0005737; GO:0006606; GO:0008139; GO:0008565; GO:0031965 0 0 0 PF03810;PF08389; A7YWS7 CHOYP_DPOE2.1.1 m.3062 sp DPOE2_BOVIN 60.769 520 202 2 4 521 5 524 0 692 DPOE2_BOVIN reviewed DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) POLE2 Bos taurus (Bovine) 527 DNA-dependent DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276] GO:0003677; GO:0003887; GO:0006261; GO:0008622; GO:0042276 0 0 0 PF04042;PF12213; A7Z019 CHOYP_SMCA4.1.1 m.54020 sp SMCA4_BOVIN 60.19 1580 485 25 184 1657 44 1585 0 1687 SMCA4_BOVIN reviewed Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) SMARCA4 BAF190A BRG1 SNF2B SNF2L4 Bos taurus (Bovine) 1606 "ATP-dependent chromatin remodeling [GO:0043044]; covalent chromatin modification [GO:0016569]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0004386; GO:0005524; GO:0006351; GO:0006355; GO:0007399; GO:0016514; GO:0016569; GO:0016887; GO:0043044; GO:0071564; GO:0071565 0 0 0 PF07533;PF00439;PF00271;PF07529;PF08880;PF14619;PF00176; A8CVX7 CHOYP_LOC584220.1.4 m.6309 sp TTLL6_DANRE 48.448 741 335 13 149 876 55 761 0 678 TTLL6_DANRE reviewed Tubulin polyglutamylase ttll6 (EC 6.-.-.-) (Tubulin tyrosine ligase-like family member 6) ttll6 Danio rerio (Zebrafish) (Brachydanio rerio) 778 axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; protein polyglutamylation [GO:0018095] GO:0003341; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0015631; GO:0018095; GO:0035082; GO:0036064; GO:0070739; GO:0070740 0 0 0 PF03133; A8CVX7 CHOYP_LOC584220.2.4 m.13160 sp TTLL6_DANRE 49.101 723 337 11 129 836 55 761 0 676 TTLL6_DANRE reviewed Tubulin polyglutamylase ttll6 (EC 6.-.-.-) (Tubulin tyrosine ligase-like family member 6) ttll6 Danio rerio (Zebrafish) (Brachydanio rerio) 778 axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; protein polyglutamylation [GO:0018095] GO:0003341; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0015631; GO:0018095; GO:0035082; GO:0036064; GO:0070739; GO:0070740 0 0 0 PF03133; A8DYE2 CHOYP_TRPM3.1.7 m.9000 sp TRPCG_DROME 50.078 1274 557 16 40 1287 115 1335 0 1276 TRPCG_DROME reviewed "Transient receptor potential cation channel trpm (Transient receptor potential cation channel, subfamily M ortholog)" Trpm CG44240 Drosophila melanogaster (Fruit fly) 2023 cell growth [GO:0016049]; divalent metal ion transport [GO:0070838]; magnesium ion homeostasis [GO:0010960]; mitochondrion organization [GO:0007005]; protein tetramerization [GO:0051262]; zinc ion homeostasis [GO:0055069] GO:0005261; GO:0007005; GO:0010960; GO:0016049; GO:0034703; GO:0046873; GO:0051262; GO:0055069; GO:0070838; GO:0097682 0 0 0 PF00520;PF16519; A8DYE2 CHOYP_TRPM3.2.7 m.10801 sp TRPCG_DROME 40.472 1228 676 12 54 1262 110 1301 0 931 TRPCG_DROME reviewed "Transient receptor potential cation channel trpm (Transient receptor potential cation channel, subfamily M ortholog)" Trpm CG44240 Drosophila melanogaster (Fruit fly) 2023 cell growth [GO:0016049]; divalent metal ion transport [GO:0070838]; magnesium ion homeostasis [GO:0010960]; mitochondrion organization [GO:0007005]; protein tetramerization [GO:0051262]; zinc ion homeostasis [GO:0055069] GO:0005261; GO:0007005; GO:0010960; GO:0016049; GO:0034703; GO:0046873; GO:0051262; GO:0055069; GO:0070838; GO:0097682 0 0 0 PF00520;PF16519; A8MWY0 CHOYP_LOC100366489.1.1 m.21907 sp K132L_HUMAN 37.666 977 560 22 35 981 61 1018 0 676 K132L_HUMAN reviewed UPF0577 protein KIAA1324-like (Estrogen-induced gene 121-like protein) (hEIG121L) KIAA1324L EIG121L Homo sapiens (Human) 1029 0 GO:0016021 0 0 0 0 A8WGF4 CHOYP_IF122.2.2 m.59794 sp IF122_XENTR 70.687 1194 342 4 1 1194 1 1186 0 1820 IF122_XENTR reviewed Intraflagellar transport protein 122 homolog ift122 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1189 cilium assembly [GO:0042384]; intraciliary retrograde transport [GO:0035721]; multicellular organism development [GO:0007275]; negative regulation of smoothened signaling pathway [GO:0045879]; protein localization to cilium [GO:0061512] GO:0005737; GO:0005856; GO:0005929; GO:0007275; GO:0030991; GO:0035721; GO:0042384; GO:0045879; GO:0061512; GO:0072372 0 0 0 PF00400; A8WHP3 CHOYP_BRAFLDRAFT_282752.1.2 m.14120 sp SC5A9_DANRE 54.025 559 256 1 13 571 100 657 0 665 SC5A9_DANRE reviewed Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) 657 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293 0 0 0 PF00474; A8WHP3 CHOYP_ISCW_ISCW012232.1.1 m.38746 sp SC5A9_DANRE 53.988 652 277 8 8 653 23 657 0 678 SC5A9_DANRE reviewed Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) 657 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293 0 0 0 PF00474; A8WHP3 CHOYP_LOC100551481.1.1 m.4910 sp SC5A9_DANRE 49.215 573 270 5 13 580 100 656 0 586 SC5A9_DANRE reviewed Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) 657 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293 0 0 0 PF00474; A8WHP3 CHOYP_SC5A9.3.5 m.27017 sp SC5A9_DANRE 51.394 574 258 6 5 574 100 656 0 620 SC5A9_DANRE reviewed Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) 657 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293 0 0 0 PF00474; A8WHP3 CHOYP_SC5A9.5.5 m.55524 sp SC5A9_DANRE 47.087 635 316 6 24 657 42 657 0 608 SC5A9_DANRE reviewed Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) 657 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293 0 0 0 PF00474; A8WIP6 CHOYP_CDK20.1.1 m.14817 sp CDK20_DANRE 80.059 341 67 1 1 340 1 341 0 575 CDK20_DANRE reviewed Cyclin-dependent kinase 20 (EC 2.7.11.22) (Cell cycle-related kinase) (Cell division protein kinase 20) cdk20 ccrk si:dkeyp-77f7.1 zgc:101530 Danio rerio (Zebrafish) (Brachydanio rerio) 344 cell cycle [GO:0007049]; cell division [GO:0051301]; cilium morphogenesis [GO:0060271]; multicellular organism development [GO:0007275] GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005929; GO:0007049; GO:0007275; GO:0051301; GO:0060271 0 0 0 PF00069; A8Y5H7 CHOYP_S14L1.1.1 m.6427 sp S14L1_MOUSE 58.898 708 260 9 1 692 1 693 0 850 S14L1_MOUSE reviewed SEC14-like protein 1 Sec14l1 Kiaa4251 Mus musculus (Mouse) 715 choline transport [GO:0015871]; innate immune response [GO:0045087]; negative regulation of RIG-I signaling pathway [GO:0039536] GO:0005737; GO:0005794; GO:0015871; GO:0016021; GO:0039536; GO:0039552; GO:0045087; GO:0098772 0 0 0 PF00650;PF03765;PF04707; A9JRI0 CHOYP_HEAT6.1.1 m.102 sp HEAT6_DANRE 38.843 1089 601 15 10 1071 48 1098 0 764 HEAT6_DANRE reviewed HEAT repeat-containing protein 6 heatr6 zgc:172359 Danio rerio (Zebrafish) (Brachydanio rerio) 1201 0 0 0 0 0 PF13251; A9JRL3 CHOYP_CBPC1.1.1 m.30712 sp CBPC1_XENTR 42.786 1199 563 21 4 1157 13 1133 0 912 CBPC1_XENTR reviewed Cytosolic carboxypeptidase 1 (EC 3.4.17.-) (ATP/GTP-binding protein 1) agtpbp1 ccp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1226 cerebellar Purkinje cell differentiation [GO:0021702]; chordate embryonic development [GO:0043009]; C-terminal protein deglutamylation [GO:0035609]; eye photoreceptor cell differentiation [GO:0001754]; mitochondrion organization [GO:0007005]; neuromuscular process [GO:0050905]; olfactory bulb development [GO:0021772]; protein side chain deglutamylation [GO:0035610] GO:0001754; GO:0004181; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0007005; GO:0008270; GO:0015631; GO:0021702; GO:0021772; GO:0035609; GO:0035610; GO:0043009; GO:0050905 0 0 0 PF00246; B0CM26 CHOYP_BRAFLDRAFT_270517.1.1 m.27028 sp CFA69_PAPAN 47.269 897 459 8 27 921 26 910 0 856 CFA69_PAPAN reviewed Cilia- and flagella-associated protein 69 CFAP69 Papio anubis (Olive baboon) 941 0 0 0 0 0 0 B0FYY4 CHOYP_ITB1B.1.1 m.59423 sp ITB1_SHEEP 41.414 792 418 18 38 800 24 798 0 588 ITB1_SHEEP reviewed Integrin beta-1 (Fibronectin receptor subunit beta) (Integrin subunit beta-1) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Ovis aries (Sheep) 798 cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; receptor internalization [GO:0031623]; regulation of collagen catabolic process [GO:0010710] GO:0004872; GO:0005925; GO:0007160; GO:0007229; GO:0008305; GO:0009986; GO:0010710; GO:0016020; GO:0030027; GO:0031623; GO:0032587; GO:0033627; GO:0042470; GO:0046872; GO:0046982; GO:0055037; GO:0071404; GO:0071438; GO:0090004 0 0 0 PF07974;PF08725;PF07965;PF00362; B0FYY4 CHOYP_LOC657674.1.1 m.21821 sp ITB1_SHEEP 43.451 794 399 20 38 800 24 798 0 633 ITB1_SHEEP reviewed Integrin beta-1 (Fibronectin receptor subunit beta) (Integrin subunit beta-1) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Ovis aries (Sheep) 798 cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; receptor internalization [GO:0031623]; regulation of collagen catabolic process [GO:0010710] GO:0004872; GO:0005925; GO:0007160; GO:0007229; GO:0008305; GO:0009986; GO:0010710; GO:0016020; GO:0030027; GO:0031623; GO:0032587; GO:0033627; GO:0042470; GO:0046872; GO:0046982; GO:0055037; GO:0071404; GO:0071438; GO:0090004 0 0 0 PF07974;PF08725;PF07965;PF00362; B0JZD0 CHOYP_CTL2.2.2 m.56999 sp CTL5_XENTR 44.105 721 371 10 23 730 13 714 0 593 CTL5_XENTR reviewed Choline transporter-like protein 5 (Solute carrier family 44 member 5) slc44a5 ctl5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 714 0 GO:0016021 0 0 0 PF04515; B0R0T1 CHOYP_VWA8.1.3 m.14479 sp VWA8_DANRE 55.36 569 240 5 3 561 294 858 0 662 VWA8_DANRE reviewed von Willebrand factor A domain-containing protein 8 si:dkey-18l1.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1896 0 GO:0005524; GO:0016887 0 0 0 PF07728; B0R0T1 CHOYP_VWA8.2.3 m.28001 sp VWA8_DANRE 54.984 1555 637 21 14 1539 374 1894 0 1696 VWA8_DANRE reviewed von Willebrand factor A domain-containing protein 8 si:dkey-18l1.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1896 0 GO:0005524; GO:0016887 0 0 0 PF07728; B0UXP9 CHOYP_IMDH3.1.1 m.51789 sp IMDH2_DANRE 79.767 514 104 0 27 540 1 514 0 863 IMDH2_DANRE reviewed Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) impdh2 si:dkey-90l2.2 Danio rerio (Zebrafish) (Brachydanio rerio) 514 GMP biosynthetic process [GO:0006177] GO:0000166; GO:0003938; GO:0005634; GO:0005737; GO:0006177; GO:0046872 PATHWAY: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. {ECO:0000255|HAMAP-Rule:MF_03156}. 0 cd00381; PF00571;PF00478; B0W6M9 CHOYP_LOC100863920.1.1 m.40408 sp SUR8_CULQU 69.231 494 152 0 102 595 132 625 0 692 SUR8_CULQU reviewed Leucine-rich repeat protein soc-2 homolog (Protein Sur-8 homolog) (Protein soc-2 homolog) Sur-8 CPIJ002780 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) 628 0 0 0 0 0 PF12799;PF13855; B1H1E4 CHOYP_LOC100370516.1.1 m.29182 sp ARI1_XENTR 70.336 536 127 6 1 511 1 529 0 768 ARI1_XENTR reviewed E3 ubiquitin-protein ligase arih1 (EC 6.3.2.-) (Protein ariadne-1 homolog) (ARI-1) arih1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 529 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0016874; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; B1MTG7 CHOYP_PI4KB.1.1 m.8669 sp PI4KB_PLEMO 58.478 749 274 12 102 844 99 816 0 852 PI4KB_PLEMO reviewed Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) PI4KB PIK4CB Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch) 816 phosphatidylinositol-mediated signaling [GO:0048015] GO:0004430; GO:0005524; GO:0005741; GO:0005794; GO:0030867; GO:0048015; GO:0071889 0 0 0 PF00454; B1WAP7 CHOYP_DVL.1.2 m.36482 sp DVL3_XENTR 63.841 578 172 13 1 561 1 558 0 639 DVL3_XENTR reviewed Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) dvl3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 713 canonical Wnt signaling pathway [GO:0060070]; ciliary basal body organization [GO:0032053]; cilium assembly [GO:0042384]; intracellular signal transduction [GO:0035556]; planar cell polarity pathway involved in neural tube closure [GO:0090179] GO:0005109; GO:0005829; GO:0008013; GO:0032053; GO:0035556; GO:0042384; GO:0060070; GO:0090179 0 0 0 PF00610;PF02377;PF00778;PF12316;PF00595; B1WAZ6 CHOYP_PA24A.2.3 m.25988 sp PA24A_XENTR 46.008 789 364 15 5 774 2 747 0 683 PA24A_XENTR reviewed Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] pla2g4a cpla2 pla2g4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 749 phospholipid catabolic process [GO:0009395] GO:0004622; GO:0004623; GO:0009395; GO:0016023; GO:0046872 0 0 0 PF00168;PF01735; B2GUY0 CHOYP_MA1B1.1.1 m.22675 sp MA1B1_RAT 48.498 666 303 12 11 661 15 655 0 604 MA1B1_RAT reviewed "Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Mannosidase alpha class 1B member 1)" Man1b1 Rattus norvegicus (Rat) 657 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; glycoprotein ERAD pathway [GO:0097466]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; N-glycan processing [GO:0006491]; trimming of terminal mannose on B branch [GO:0036509] GO:0004571; GO:0005509; GO:0005783; GO:0005789; GO:0006491; GO:0016021; GO:0030433; GO:0036509; GO:0044322; GO:0097466; GO:1903561; GO:1904382 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P32906}. 0 0 PF01532; B2GV06 CHOYP_SCOT1.1.1 m.59655 sp SCOT1_RAT 66.794 524 168 3 1 522 1 520 0 722 SCOT1_RAT reviewed "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)" Oxct1 Oxct Scot Rattus norvegicus (Rat) 520 adipose tissue development [GO:0060612]; brain development [GO:0007420]; cellular ketone body metabolic process [GO:0046950]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to nutrient [GO:0007584]; response to starvation [GO:0042594] GO:0005739; GO:0005759; GO:0007420; GO:0007507; GO:0007584; GO:0008260; GO:0009725; GO:0014823; GO:0035774; GO:0042182; GO:0042493; GO:0042594; GO:0042803; GO:0045471; GO:0046950; GO:0046952; GO:0060612 PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. {ECO:0000250|UniProtKB:P55809}. 0 0 PF01144; B2KI97 CHOYP_THOC2.1.2 m.9631 sp THOC2_RHIFE 48.491 1590 710 21 24 1548 4 1549 0 1419 THOC2_RHIFE reviewed THO complex subunit 2 (Tho2) THOC2 Rhinolophus ferrumequinum (Greater horseshoe bat) 1576 generation of neurons [GO:0048699]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; neuron development [GO:0048666]; RNA splicing [GO:0008380] GO:0003723; GO:0006397; GO:0008380; GO:0016607; GO:0048666; GO:0048699; GO:0051028 0 0 0 PF11262;PF11732;PF16134; B2KI97 CHOYP_THOC2.2.2 m.19049 sp THOC2_RHIFE 55.971 1231 502 12 1020 2218 13 1235 0 1389 THOC2_RHIFE reviewed THO complex subunit 2 (Tho2) THOC2 Rhinolophus ferrumequinum (Greater horseshoe bat) 1576 generation of neurons [GO:0048699]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; neuron development [GO:0048666]; RNA splicing [GO:0008380] GO:0003723; GO:0006397; GO:0008380; GO:0016607; GO:0048666; GO:0048699; GO:0051028 0 0 0 PF11262;PF11732;PF16134; B2RC85 CHOYP_LOC592857.1.1 m.62834 sp R10B2_HUMAN 47.943 559 284 5 1 555 94 649 0 569 R10B2_HUMAN reviewed Radial spoke head 10 homolog B2 RSPH10B2 Homo sapiens (Human) 870 0 0 0 0 0 PF02493; B2RR83 CHOYP_YTDC2.1.1 m.58330 sp YTDC2_MOUSE 52.988 1389 608 14 28 1377 52 1434 0 1488 YTDC2_MOUSE reviewed Probable ATP-dependent RNA helicase YTHDC2 (EC 3.6.4.13) Ythdc2 Mus musculus (Mouse) 1445 positive regulation by host of viral genome replication [GO:0044829]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0006396; GO:0008186; GO:0034612; GO:0044822; GO:0044829; GO:0070063; GO:0070555; GO:1990247 0 0 0 PF00270;PF04408;PF00271;PF07717;PF01424;PF04146; B2RW38 CHOYP_LOC100366451.1.1 m.10500 sp CFA58_MOUSE 67.281 868 280 2 1 867 1 865 0 1131 CFA58_MOUSE reviewed Cilia- and flagella-associated protein 58 Cfap58 Mus musculus (Mouse) 873 0 GO:0005615; GO:0005929 0 0 0 0 B2RX12 CHOYP_MRP1.6.10 m.35950 sp MRP3_MOUSE 45.732 1570 770 22 14 1560 12 1522 0 1384 MRP3_MOUSE reviewed Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) Abcc3 Cmoat2 Mrp3 Mus musculus (Mouse) 1523 canalicular bile acid transport [GO:0015722] GO:0005524; GO:0005887; GO:0015722; GO:0042626 0 0 0 PF00664;PF00005; B2RY50 CHOYP_BRAFLDRAFT_126603.1.1 m.31078 sp ARMC4_MOUSE 55.81 1093 406 17 1 1072 1 1037 0 1119 ARMC4_MOUSE reviewed Armadillo repeat-containing protein 4 Armc4 Mus musculus (Mouse) 1037 cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium beat frequency [GO:0003356]; ventricular system development [GO:0021591] GO:0003341; GO:0003356; GO:0005634; GO:0005654; GO:0005737; GO:0005930; GO:0007368; GO:0007507; GO:0021591; GO:0036158; GO:0097546 0 0 0 PF00514; B2ZGJ1 CHOYP_CHAT.1.1 m.36652 sp CLAT_DANRE 49.755 613 294 2 30 641 18 617 0 640 CLAT_DANRE reviewed Choline O-acetyltransferase (CHOACTase) (ChAT) (Choline acetylase) (EC 2.3.1.6) chat Danio rerio (Zebrafish) (Brachydanio rerio) 637 locomotory behavior [GO:0007626]; neurotransmitter biosynthetic process [GO:0042136] GO:0004102; GO:0007626; GO:0042136 0 0 0 PF00755; B3EWZ5 CHOYP_LOC580670.1.6 m.4084 sp MLRP1_ACRMI 36.217 5456 2691 174 152 5140 12 5145 0 2926 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ5 CHOYP_NEMVEDRAFT_V1G239043.2.6 m.4886 sp MLRP1_ACRMI 38.303 3830 1918 111 25 3612 988 4614 0 2292 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ5 CHOYP_NEMVEDRAFT_V1G239043.2.6 m.4887 sp MLRP1_ACRMI 49.11 674 318 14 1 659 854 1517 0 627 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.1.15 m.3453 sp MLRP2_ACRMI 41.95 2646 1341 64 25 2613 201 2708 0 1933 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.2.15 m.3883 sp MLRP2_ACRMI 41.612 2456 1254 60 25 2429 201 2527 0 1772 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.3.15 m.3888 sp MLRP2_ACRMI 46.769 1439 664 36 7 1410 112 1483 0 1186 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.7.15 m.17602 sp MLRP2_ACRMI 46.884 674 316 15 1 660 291 936 0 585 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ6 CHOYP_NEMVEDRAFT_V1G239043.5.6 m.29689 sp MLRP2_ACRMI 33.438 2548 1341 83 4 2314 3330 5759 0 1149 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B4KD90 CHOYP_LOC100533321.1.1 m.38814 sp NMDA1_DROMO 52.254 865 390 8 24 871 35 893 0 929 NMDA1_DROMO reviewed Glutamate [NMDA] receptor subunit 1 Nmdar1 GI24494 Drosophila mojavensis (Fruit fly) 980 calcium ion homeostasis [GO:0055074]; chemical synaptic transmission [GO:0007268]; ionotropic glutamate receptor signaling pathway [GO:0035235]; long-term memory [GO:0007616]; olfactory learning [GO:0008355]; regulation of membrane potential [GO:0042391] GO:0004970; GO:0005234; GO:0007268; GO:0007616; GO:0008355; GO:0014069; GO:0017146; GO:0030054; GO:0035235; GO:0042391; GO:0045211; GO:0055074 0 0 0 PF01094;PF10562;PF00060;PF10613; B4NYV0 CHOYP_ISCW_ISCW011341.1.1 m.18728 sp SRRT_DROYA 43.902 902 379 23 39 849 1 866 0 634 SRRT_DROYA reviewed Serrate RNA effector molecule homolog (Arsenite-resistance protein 2 homolog) Ars2 GE19427 Drosophila yakuba (Fruit fly) 944 primary miRNA processing [GO:0031053]; RNA interference [GO:0016246] GO:0005654; GO:0016246; GO:0031053 0 0 0 PF04959;PF12066; B4PSS5 CHOYP_LOC100369315.1.2 m.26451 sp PDE6_DROYA 53.358 804 324 9 41 795 193 994 0 882 PDE6_DROYA reviewed "cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35)" Pde6 GE26445 Drosophila yakuba (Fruit fly) 1149 cGMP metabolic process [GO:0046068]; signal transduction [GO:0007165] GO:0005886; GO:0007165; GO:0016020; GO:0046068; GO:0046872; GO:0047555 0 0 0 PF01590;PF00233; B4PSS5 CHOYP_LOC100369315.2.2 m.47331 sp PDE6_DROYA 51.962 841 350 9 41 847 193 1013 0 889 PDE6_DROYA reviewed "cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35)" Pde6 GE26445 Drosophila yakuba (Fruit fly) 1149 cGMP metabolic process [GO:0046068]; signal transduction [GO:0007165] GO:0005886; GO:0007165; GO:0016020; GO:0046068; GO:0046872; GO:0047555 0 0 0 PF01590;PF00233; B4ZIX8 CHOYP_LOC411194.1.1 m.8500 sp SCC4_XENLA 58.151 595 238 6 21 610 2 590 0 712 SCC4_XENLA reviewed MAU2 chromatid cohesion factor homolog (MAU-2) (Cohesin loading complex subunit SCC4 homolog) mau2 Xenopus laevis (African clawed frog) 607 cell division [GO:0051301]; maintenance of mitotic sister chromatid cohesion [GO:0034088] GO:0000785; GO:0005634; GO:0005654; GO:0032116; GO:0034088; GO:0051301 0 0 0 PF10345; B5X1G3 CHOYP_GPHR.1.1 m.57014 sp GPHR_SALSA 69.231 390 117 1 23 412 1 387 0 548 GPHR_SALSA reviewed Golgi pH regulator (Protein gpr89) gpr89 gphr Salmo salar (Atlantic salmon) 455 protein transport [GO:0015031] GO:0000139; GO:0005244; GO:0015031; GO:0016021 0 0 0 PF12430;PF12537; B5X3C1 CHOYP_LOC100376265.3.4 m.22693 sp GALC_SALSA 53.353 671 296 12 31 697 5 662 0 680 GALC_SALSA reviewed Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc Salmo salar (Atlantic salmon) 666 carbohydrate metabolic process [GO:0005975]; galactosylceramide catabolic process [GO:0006683] GO:0004336; GO:0005764; GO:0005975; GO:0006683 0 0 0 PF02057; B6CHA3 CHOYP_UHRF1.1.1 m.10935 sp UHRF1_XENLA 57.447 799 306 9 1 792 1 772 0 915 UHRF1_XENLA reviewed E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Nuclear zinc finger protein Np95) (XNp95) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) uhrf1 np95 Xenopus laevis (African clawed frog) 772 "cell cycle [GO:0007049]; histone ubiquitination [GO:0016574]; maintenance of DNA methylation [GO:0010216]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein autoubiquitination [GO:0051865]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0000791; GO:0000792; GO:0004842; GO:0005657; GO:0006351; GO:0007049; GO:0008270; GO:0010216; GO:0016574; GO:0016874; GO:0035064; GO:0042393; GO:0042787; GO:0044729; GO:0051865 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00628;PF02182;PF12148;PF00240; B6ZLK2 CHOYP_CHD2.1.1 m.36132 sp CHD1_CHICK 52.635 1651 643 32 187 1800 170 1718 0 1511 CHD1_CHICK reviewed Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) CHD1 Gallus gallus (Chicken) 1719 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000775; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF00385;PF13907;PF00271;PF00176; B6ZLK2 CHOYP_LOC100375547.1.1 m.23273 sp CHD1_CHICK 62.5 456 163 5 198 653 228 675 0 610 CHD1_CHICK reviewed Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.12) (ATP-dependent helicase CHD1) CHD1 Gallus gallus (Chicken) 1719 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000775; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF00385;PF13907;PF00271;PF00176; B9EJ86 CHOYP_OSBPL8.1.1 m.59098 sp OSBL8_MOUSE 61.071 691 242 9 71 739 101 786 0 868 OSBL8_MOUSE reviewed Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) Osbpl8 Kiaa1451 Orp8 Mus musculus (Mouse) 889 activation of protein kinase B activity [GO:0032148]; fat cell differentiation [GO:0045444]; negative regulation of cell migration [GO:0030336]; negative regulation of sequestering of triglyceride [GO:0010891]; phospholipid transport [GO:0015914]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein kinase B signaling [GO:0051897]; protein localization to nuclear pore [GO:0090204] GO:0001786; GO:0005548; GO:0005789; GO:0010891; GO:0015485; GO:0015914; GO:0016020; GO:0016021; GO:0030336; GO:0031965; GO:0032148; GO:0032541; GO:0045444; GO:0046628; GO:0051897; GO:0070273; GO:0090204; GO:2001275 0 0 0 PF01237;PF00169; B9EJR8 CHOYP_BRAFLDRAFT_64948.1.1 m.17321 sp DAAF5_MOUSE 41.99 824 469 5 13 827 26 849 0 671 DAAF5_MOUSE reviewed "Dynein assembly factor 5, axonemal (HEAT repeat-containing protein 2)" Dnaaf5 Heatr2 Mus musculus (Mouse) 853 cilium movement [GO:0003341]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158] GO:0003341; GO:0005737; GO:0036158; GO:0036159; GO:0045505 0 0 0 PF12755; C0H906 CHOYP_LOC661829.1.1 m.64858 sp NCBP1_SALSA 60.427 796 303 3 1 787 1 793 0 1035 NCBP1_SALSA reviewed Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit) ncbp1 cbp80 Salmo salar (Atlantic salmon) 796 "7-methylguanosine mRNA capping [GO:0006370]; gene silencing by RNA [GO:0031047]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translation [GO:0006417]" GO:0000184; GO:0000339; GO:0005634; GO:0005737; GO:0005846; GO:0006370; GO:0006406; GO:0006417; GO:0031047; GO:0045292 0 0 0 PF02854;PF09088;PF09090; C3XRY1 CHOYP_LOC577190.1.1 m.18117 sp NO66_BRAFL 57.143 441 165 2 255 695 185 601 0 546 NO66_BRAFL reviewed Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 (EC 1.14.11.-) (EC 1.14.11.27) (Histone lysine demethylase NO66) BRAFLDRAFT_123918 Branchiostoma floridae (Florida lancelet) (Amphioxus) 607 "chromatin remodeling [GO:0006338]; histone H3-K36 demethylation [GO:0070544]; histone H3-K4 demethylation [GO:0034720]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-amino acid modification [GO:0018193]; post-translational protein modification [GO:0043687]; ribosome biogenesis [GO:0042254]; transcription, DNA-templated [GO:0006351]" GO:0005506; GO:0005634; GO:0006338; GO:0006351; GO:0016706; GO:0018193; GO:0032453; GO:0034720; GO:0042254; GO:0043687; GO:0045892; GO:0051864; GO:0070544 0 0 0 PF08007; C3XVT5 CHOYP_LIS1.1.1 m.56212 sp LIS1_BRAFL 75.735 408 97 1 1 408 1 406 0 679 LIS1_BRAFL reviewed Lissencephaly-1 homolog BRAFLDRAFT_59218 Branchiostoma floridae (Florida lancelet) (Amphioxus) 406 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; germ cell development [GO:0007281]; microtubule organizing center organization [GO:0031023]; mitotic nuclear division [GO:0007067]; neurogenesis [GO:0022008]; nuclear migration [GO:0007097]; regulation of microtubule motor activity [GO:2000574]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496] GO:0000132; GO:0000776; GO:0005813; GO:0005874; GO:0005875; GO:0005938; GO:0007067; GO:0007097; GO:0007281; GO:0008017; GO:0008090; GO:0022008; GO:0031023; GO:0045502; GO:0047496; GO:0051301; GO:1904115; GO:2000574 0 0 0 PF08513;PF00400; C3YWU0 CHOYP_FUCO.1.2 m.58756 sp FUCO_BRAFL 59.268 437 172 3 22 457 17 448 0 561 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_FUCO.2.2 m.58905 sp FUCO_BRAFL 63.991 436 152 2 36 470 17 448 0 608 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC100367436.1.1 m.20579 sp FUCO_BRAFL 60.78 436 165 3 25 458 17 448 0 567 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC592142.1.9 m.13270 sp FUCO_BRAFL 58.81 437 174 3 21 456 17 448 0 555 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC592142.3.9 m.36414 sp FUCO_BRAFL 57.506 433 180 3 21 452 17 446 0 549 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC592142.4.9 m.49474 sp FUCO_BRAFL 57.471 435 181 3 22 455 17 448 0 552 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC592142.5.9 m.53066 sp FUCO_BRAFL 54.462 437 194 3 30 464 12 445 0 526 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC592142.6.9 m.54976 sp FUCO_BRAFL 59.039 437 173 3 22 457 17 448 0 557 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC592142.7.9 m.55467 sp FUCO_BRAFL 62.844 436 157 2 38 472 17 448 0 594 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C3YWU0 CHOYP_LOC592142.9.9 m.64877 sp FUCO_BRAFL 55.378 437 190 3 25 459 12 445 0 527 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; C8YR32 CHOYP_LOC100378579.1.1 m.31803 sp LOXH1_MOUSE 32.552 2175 1224 47 298 2396 45 2052 0 1096 LOXH1_MOUSE reviewed Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) 2068 detection of mechanical stimulus [GO:0050982]; sensory perception of sound [GO:0007605] GO:0005262; GO:0007605; GO:0016020; GO:0032420; GO:0050982 0 0 0 PF01477; C9D7C2 CHOYP_LOC100647135.1.2 m.21531 sp CAC1A_APIME 60.093 1719 552 21 32 1711 1 1624 0 1904 CAC1A_APIME reviewed Voltage-dependent calcium channel type A subunit alpha-1 (Cacophony protein) CAC Apis mellifera (Honeybee) 1904 0 GO:0005245; GO:0005509; GO:0005891 0 0 0 PF08763;PF16905;PF00520; C9D7C2 CHOYP_LOC100647135.2.2 m.22549 sp CAC1A_APIME 56.04 1904 661 25 32 1893 1 1770 0 1912 CAC1A_APIME reviewed Voltage-dependent calcium channel type A subunit alpha-1 (Cacophony protein) CAC Apis mellifera (Honeybee) 1904 0 GO:0005245; GO:0005509; GO:0005891 0 0 0 PF08763;PF16905;PF00520; C9WPN6 CHOYP_IF2H.1.1 m.18253 sp IF2H_RAT 83.721 473 76 1 28 500 1 472 0 807 IF2H_RAT reviewed "Eukaryotic translation initiation factor 2 subunit 3, Y-linked (Eukaryotic translation initiation factor 2 subunit gamma, Y-linked) (eIF-2-gamma Y)" Eif2s3y Rattus norvegicus (Rat) 472 0 GO:0003743; GO:0003924; GO:0005525 0 0 cd15490; PF09173;PF03144; D2I1E3 CHOYP_ARP8.1.1 m.10729 sp ARP8_AILME 48.576 597 283 8 14 594 36 624 0 583 ARP8_AILME reviewed Actin-related protein 8 ACTR8 ARP8 PANDA_019105 Ailuropoda melanoleuca (Giant panda) 624 "cell division [GO:0051301]; chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005813; GO:0006281; GO:0006310; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0031011; GO:0051301 0 0 0 PF00022; D3YXG0 CHOYP_HMCN1.28.44 m.47379 sp HMCN1_MOUSE 35.925 3730 2205 61 461 4051 1951 5634 0 2284 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D3YXS5 CHOYP_LOC100182352.2.2 m.64092 sp KIF28_MOUSE 40.023 877 463 21 4 865 10 838 0 620 KIF28_MOUSE reviewed Kinesin-like protein KIF28P (Kinesin-like protein 6) Kif28p Gm1305 Klp6 Mus musculus (Mouse) 1028 cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384] GO:0003777; GO:0005524; GO:0005622; GO:0005871; GO:0007005; GO:0007018; GO:0016887; GO:0030705; GO:0031966; GO:0072384 0 0 0 PF00498;PF12423;PF00225; D3ZD32 CHOYP_CHD5.2.2 m.28708 sp CHD5_RAT 57.536 1924 580 36 89 1924 125 1899 0 2051 CHD5_RAT reviewed Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) Chd5 Rattus norvegicus (Rat) 1948 "cerebral cortex neuron differentiation [GO:0021895]; histone H3-K27 trimethylation [GO:0098532]; histone H4 acetylation [GO:0043967]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription involved in cell fate commitment [GO:0060850]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000792; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0006366; GO:0008026; GO:0008270; GO:0016581; GO:0021895; GO:0035093; GO:0043967; GO:0060850; GO:0061628; GO:0098532; GO:1901798 0 0 0 PF08074;PF08073;PF00385;PF06461;PF06465;PF00271;PF00628;PF00176; D3ZHA0 CHOYP_FLNC.4.5 m.40630 sp FLNC_RAT 44.316 2516 1220 48 460 2834 250 2725 0 1812 FLNC_RAT reviewed Filamin-C (FLN-C) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Flnc Abpl Fln2 Rattus norvegicus (Rat) 2726 muscle fiber development [GO:0048747] GO:0005856; GO:0005925; GO:0016528; GO:0030018; GO:0030506; GO:0042383; GO:0043034; GO:0048747 0 0 0 PF00307;PF00630; D3ZHA0 CHOYP_FLNC.5.5 m.40834 sp FLNC_RAT 44.843 2482 1198 45 583 2929 278 2723 0 1834 FLNC_RAT reviewed Filamin-C (FLN-C) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Flnc Abpl Fln2 Rattus norvegicus (Rat) 2726 muscle fiber development [GO:0048747] GO:0005856; GO:0005925; GO:0016528; GO:0030018; GO:0030506; GO:0042383; GO:0043034; GO:0048747 0 0 0 PF00307;PF00630; D3ZSI8 CHOYP_LOC663424.1.2 m.49957 sp PI51A_RAT 54.613 542 185 11 28 564 17 502 0 558 PI51A_RAT reviewed Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) Pip5k1a Rattus norvegicus (Rat) 546 actin cytoskeleton reorganization [GO:0031532]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; phospholipid biosynthetic process [GO:0008654]; protein targeting to plasma membrane [GO:0072661]; ruffle assembly [GO:0097178] GO:0005524; GO:0005737; GO:0005847; GO:0005925; GO:0008654; GO:0010761; GO:0016308; GO:0016607; GO:0030027; GO:0031532; GO:0032587; GO:0048041; GO:0060326; GO:0072661; GO:0090630; GO:0097178 0 0 0 PF01504; D3ZSZ3 CHOYP_LOC100313664.1.1 m.37913 sp NLK_RAT 83.285 347 58 0 48 394 137 483 0 617 NLK_RAT reviewed Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) Nlk Rattus norvegicus (Rat) 527 "negative regulation of Wnt signaling pathway [GO:0030178]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; protein stabilization [GO:0050821]; regulation of transcription, DNA-templated [GO:0006355]; serine phosphorylation of STAT3 protein [GO:0033136]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]; Wnt signaling pathway [GO:0016055]" GO:0000287; GO:0004707; GO:0005524; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007179; GO:0016055; GO:0018107; GO:0030178; GO:0033136; GO:0046777; GO:0050821 0 0 0 PF00069; D3ZVM4 CHOYP_LOC100367035.1.1 m.9457 sp LIN41_RAT 54.883 809 311 8 25 787 55 855 0 889 LIN41_RAT reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) Trim71 Lin41 Rattus norvegicus (Rat) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; D7REX8 CHOYP_UN45B.1.1 m.19072 sp UN45B_XENTR 42.066 939 510 16 13 938 7 924 0 736 UN45B_XENTR reviewed Protein unc-45 homolog B (Unc-45B) unc45b cmya4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 927 cardiac muscle tissue development [GO:0048738]; lens development in camera-type eye [GO:0002088]; muscle fiber development [GO:0048747]; myofibril assembly [GO:0030239]; skeletal muscle tissue development [GO:0007519] GO:0002088; GO:0005829; GO:0007519; GO:0030018; GO:0030239; GO:0048738; GO:0048747 0 0 0 PF11701; E1BD52 CHOYP_BRAFLDRAFT_85004.1.1 m.42136 sp TM245_BOVIN 41.461 849 419 18 26 839 50 855 0 572 TM245_BOVIN reviewed Transmembrane protein 245 TMEM245 Bos taurus (Bovine) 868 0 GO:0016021 0 0 0 PF01594; E1BMP7 CHOYP_DNA2.1.5 m.17853 sp DNA2_BOVIN 41.373 1020 534 24 64 1045 55 1048 0 725 DNA2_BOVIN reviewed DNA replication ATP-dependent helicase/nuclease DNA2 (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)] DNA2 Bos taurus (Bovine) 1061 "DNA double-strand break processing [GO:0000729]; DNA replication [GO:0006260]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA replication checkpoint [GO:0000076]" GO:0000076; GO:0000729; GO:0003677; GO:0003678; GO:0004518; GO:0005524; GO:0005634; GO:0005739; GO:0006260; GO:0017108; GO:0033567; GO:0043139; GO:0043142; GO:0046872; GO:0051539 0 0 0 PF08696; E1BYJ2 CHOYP_BRAFLDRAFT_283756.1.1 m.16258 sp MSH6_CHICK 52.81 1299 559 21 79 1357 49 1313 0 1332 MSH6_CHICK reviewed DNA mismatch repair protein Msh6 MSH6 Gallus gallus (Chicken) 1337 determination of adult lifespan [GO:0008340]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; maintenance of DNA repeat elements [GO:0043570]; meiotic mismatch repair [GO:0000710]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of DNA recombination [GO:0045910]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of helicase activity [GO:0051096]; positive regulation of isotype switching [GO:0045830]; reciprocal meiotic recombination [GO:0007131]; response to UV [GO:0009411]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0000228; GO:0000287; GO:0000400; GO:0000710; GO:0000790; GO:0003682; GO:0003684; GO:0005524; GO:0005654; GO:0005794; GO:0005886; GO:0007095; GO:0007131; GO:0008340; GO:0008630; GO:0009411; GO:0016446; GO:0016887; GO:0030890; GO:0032137; GO:0032138; GO:0032142; GO:0032143; GO:0032301; GO:0032357; GO:0032876; GO:0043531; GO:0043570; GO:0045190; GO:0045830; GO:0045910; GO:0051096 0 0 0 PF01624;PF05188;PF05192;PF05190;PF00488;PF00855; E1BZ85 CHOYP_MARF1.1.1 m.24918 sp MARF1_CHICK 39.553 895 492 13 505 1351 782 1675 0 638 MARF1_CHICK reviewed Meiosis arrest female protein 1 homolog (Limkain-b1) MARF1 LKAP Gallus gallus (Chicken) 1741 meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468] GO:0000166; GO:0003723; GO:0005777; GO:0010468; GO:0048477; GO:0051321 0 0 0 PF11608;PF01936;PF12872; E1C2V1 CHOYP_LMBL3.1.1 m.14251 sp LMBL1_CHICK 40.387 827 369 22 677 1457 96 844 0 595 LMBL1_CHICK reviewed Lethal(3)malignant brain tumor-like protein 1 (H-l(3)mbt) (H-l(3)mbt protein) (L(3)mbt-like) (L(3)mbt protein homolog) L3MBTL1 L3MBT L3MBTL Gallus gallus (Chicken) 847 "covalent chromatin modification [GO:0016569]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0008270; GO:0016569; GO:0035064 0 0 0 PF02820;PF00536;PF01530; E7EY42 CHOYP_PTSS2.1.1 m.65977 sp PTSS2_DANRE 58.726 424 168 5 31 448 23 445 0 535 PTSS2_DANRE reviewed Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) ptdss2 si:ch1073-158c2 si:ch1073-279O1 Danio rerio (Zebrafish) (Brachydanio rerio) 452 phosphatidylserine biosynthetic process [GO:0006659]; phospholipid biosynthetic process [GO:0008654] GO:0005789; GO:0006659; GO:0008654; GO:0016021; GO:0016740 PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis. 0 0 PF03034; E9PVA8 CHOYP_GCN1L.1.1 m.1352 sp GCN1_MOUSE 51.119 2682 1286 16 6 2674 1 2670 0 2597 GCN1_MOUSE reviewed eIF-2-alpha kinase activator GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) Gcn1 Gcn1l1 Mus musculus (Mouse) 2671 cellular response to amino acid starvation [GO:0034198]; cellular response to leucine starvation [GO:1990253]; positive regulation of kinase activity [GO:0033674]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of translation [GO:0006417] GO:0005737; GO:0005844; GO:0006417; GO:0016020; GO:0019887; GO:0033674; GO:0034198; GO:0036003; GO:0043022; GO:0044822; GO:1990253 0 0 0 0 E9Q1U1 CHOYP_CC171.1.1 m.55237 sp CC171_MOUSE 36.025 1263 734 14 101 1313 22 1260 0 716 CC171_MOUSE reviewed Coiled-coil domain-containing protein 171 Ccdc171 Mus musculus (Mouse) 1324 0 0 0 0 0 0 E9Q555 CHOYP_RN213.10.13 m.56907 sp RN213_MOUSE 43.677 854 445 16 920 1760 1733 2563 0 650 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 E9Q5G3 CHOYP_LOC373240.1.1 m.12462 sp KIF23_MOUSE 47.126 696 339 10 58 742 24 701 0 611 KIF23_MOUSE reviewed Kinesin-like protein KIF23 Kif23 Mus musculus (Mouse) 953 actomyosin contractile ring assembly [GO:0000915]; microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of cytokinesis [GO:0032467] GO:0000281; GO:0000915; GO:0003777; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0005871; GO:0005874; GO:0005925; GO:0007018; GO:0008017; GO:0016887; GO:0030496; GO:0032467; GO:0045171; GO:0051256; GO:0072383; GO:0072686; GO:0097149 0 0 0 PF00225;PF16540; E9Q6P5 CHOYP_LOC100374011.1.1 m.52440 sp TTC7B_MOUSE 43.662 852 439 14 7 826 1 843 0 654 TTC7B_MOUSE reviewed Tetratricopeptide repeat protein 7B (TPR repeat protein 7B) Ttc7b Mus musculus (Mouse) 843 establishment of protein localization to plasma membrane [GO:0090002]; phosphatidylinositol phosphorylation [GO:0046854] GO:0005829; GO:0005886; GO:0046854; GO:0090002 0 0 0 PF13374;PF07719;PF13181; E9Q8I9 CHOYP_LOC657755.1.1 m.501 sp FRY_MOUSE 39.077 3012 1604 64 27 2878 54 2994 0 1844 FRY_MOUSE reviewed Protein furry homolog Fry Kiaa4143 Mus musculus (Mouse) 3020 actin filament reorganization [GO:0090527]; cell morphogenesis [GO:0000902]; negative regulation of tubulin deacetylation [GO:1904428]; neuron projection development [GO:0031175] GO:0000902; GO:0000922; GO:0004857; GO:0005815; GO:0005938; GO:0030427; GO:0031175; GO:0090527; GO:1904428 0 0 0 PF14225;PF14228;PF14222; E9QAM5 CHOYP_BRAFLDRAFT_90929.1.1 m.54454 sp HELZ2_MOUSE 27.706 2411 1446 74 1033 3361 208 2403 0 756 HELZ2_MOUSE reviewed Helicase with zinc finger domain 2 (EC 3.6.4.-) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) Helz2 Mus musculus (Mouse) 2947 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 F1M7Y5 CHOYP_LOC100533284.1.2 m.25143 sp KPCI_RAT 67.687 588 173 2 12 599 26 596 0 847 KPCI_RAT reviewed Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) Prkci Pkcl Rattus norvegicus (Rat) 596 actin filament organization [GO:0007015]; cell-cell junction organization [GO:0045216]; cell migration [GO:0016477]; cellular protein localization [GO:0034613]; cellular response to insulin stimulus [GO:0032869]; establishment of apical/basal cell polarity [GO:0035089]; eye photoreceptor cell development [GO:0042462]; Golgi vesicle budding [GO:0048194]; intracellular signal transduction [GO:0035556]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of neuron apoptotic process [GO:0043524]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of glucose import [GO:0046326]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein phosphorylation [GO:0006468]; response to interleukin-1 [GO:0070555]; response to peptide hormone [GO:0043434] GO:0000139; GO:0004672; GO:0004697; GO:0005524; GO:0005543; GO:0005634; GO:0005768; GO:0005829; GO:0005886; GO:0006468; GO:0007015; GO:0010976; GO:0015630; GO:0016324; GO:0016477; GO:0018105; GO:0019904; GO:0031252; GO:0032869; GO:0034351; GO:0034613; GO:0035089; GO:0035556; GO:0042462; GO:0043220; GO:0043234; GO:0043434; GO:0043524; GO:0045171; GO:0045216; GO:0046326; GO:0046872; GO:0048194; GO:0051092; GO:0060252; GO:0070062; GO:0070555; GO:0090004; GO:2000353 0 0 0 PF00130;PF00564;PF00069;PF00433; F1MA98 CHOYP_TPR.2.2 m.46877 sp TPR_RAT 32.401 1824 1071 28 14 1803 5 1700 0 785 TPR_RAT reviewed Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) Tpr Rattus norvegicus (Rat) 2360 cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; MAPK import into nucleus [GO:0000189]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; positive regulation of heterochromatin assembly [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein export from nucleus [GO:0006611]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404] GO:0000122; GO:0000189; GO:0000776; GO:0003682; GO:0003729; GO:0005487; GO:0005635; GO:0005643; GO:0005737; GO:0005868; GO:0006404; GO:0006405; GO:0006611; GO:0006999; GO:0007067; GO:0007094; GO:0010965; GO:0019898; GO:0031072; GO:0031453; GO:0031965; GO:0031990; GO:0034399; GO:0034605; GO:0035457; GO:0042307; GO:0042405; GO:0042803; GO:0044615; GO:0045947; GO:0046827; GO:0046832; GO:0051019; GO:0051301; GO:0070849; GO:0072686; GO:0090267; GO:0090316; GO:1901673 0 0 0 PF07926; F1NTD6 CHOYP_ASCC3.1.1 m.51755 sp ASCC3_CHICK 63.39 2218 775 17 3 2194 2 2208 0 2904 ASCC3_CHICK reviewed Activating signal cointegrator 1 complex subunit 3 (EC 3.6.4.12) ascc3 Gallus gallus (Chicken) 2211 "cell proliferation [GO:0008283]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA duplex unwinding [GO:0032508]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005634; GO:0005794; GO:0006307; GO:0006351; GO:0006355; GO:0008283; GO:0016020; GO:0032508; GO:0043140; GO:0044822 0 0 0 PF00270;PF00271;PF02889; F1NY98 CHOYP_LOC100533228.1.1 m.54604 sp DSCAM_CHICK 37.648 1607 962 18 45 1638 62 1641 0 1046 DSCAM_CHICK reviewed Down syndrome cell adhesion molecule homolog DSCAM Gallus gallus (Chicken) 2034 camera-type eye photoreceptor cell differentiation [GO:0060219]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] GO:0005887; GO:0007156; GO:0007162; GO:0007416; GO:0007626; GO:0010842; GO:0030054; GO:0030424; GO:0030426; GO:0042327; GO:0045202; GO:0048813; GO:0048842; GO:0060060; GO:0060219; GO:0070593 0 0 0 PF00041;PF07679; F1P4W9 CHOYP_LOC100373429.1.1 m.10007 sp CFA65_CHICK 38.28 1779 1015 17 69 1822 31 1751 0 1240 CFA65_CHICK reviewed Cilia- and flagella-associated protein 65 (Coiled-coil domain-containing protein 108) CFAP65 CCDC108 Gallus gallus (Chicken) 1775 0 GO:0044822 0 0 0 PF15780; F1Q4S1 CHOYP_ATP9B.1.2 m.25966 sp ATP9B_DANRE 68.508 1086 331 6 1 1076 40 1124 0 1550 ATP9B_DANRE reviewed Probable phospholipid-transporting ATPase IIB (EC 3.6.3.1) (ATPase class II type 9B) atp9b Danio rerio (Zebrafish) (Brachydanio rerio) 1125 "endocytosis [GO:0006897]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000287; GO:0004012; GO:0005524; GO:0005768; GO:0005802; GO:0005886; GO:0006890; GO:0006897; GO:0016021 0 0 0 PF00122;PF16212;PF16209; F4KGU4 CHOYP_LOC100632169.2.6 m.34281 sp DEAHC_ARATH 32.502 1523 919 36 1161 2623 298 1771 0 717 DEAHC_ARATH reviewed "ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)" At5g10370 F12B17_280 Arabidopsis thaliana (Mouse-ear cress) 1775 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006396; GO:0008270; GO:0009507; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF01485;PF07717;PF13445; F4KGU4 CHOYP_LOC100632169.4.6 m.51808 sp DEAHC_ARATH 32.96 1517 920 37 1221 2681 298 1773 0 732 DEAHC_ARATH reviewed "ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)" At5g10370 F12B17_280 Arabidopsis thaliana (Mouse-ear cress) 1775 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006396; GO:0008270; GO:0009507; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF01485;PF07717;PF13445; F4KGU4 CHOYP_LOC100632169.5.6 m.55699 sp DEAHC_ARATH 32.333 1599 973 38 1021 2551 216 1773 0 744 DEAHC_ARATH reviewed "ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)" At5g10370 F12B17_280 Arabidopsis thaliana (Mouse-ear cress) 1775 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006396; GO:0008270; GO:0009507; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF01485;PF07717;PF13445; F4KGU4 CHOYP_Y4102.1.1 m.35926 sp DEAHC_ARATH 31.113 1501 956 35 260 1711 298 1769 0 694 DEAHC_ARATH reviewed "ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)" At5g10370 F12B17_280 Arabidopsis thaliana (Mouse-ear cress) 1775 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006396; GO:0008270; GO:0009507; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF01485;PF07717;PF13445; F6P3G4 CHOYP_LOC100370665.1.1 m.29815 sp PS11A_DANRE 71.875 416 117 0 2 417 6 421 0 634 PS11A_DANRE reviewed 26S proteasome non-ATPase regulatory subunit 11A (26S proteasome regulatory subunit RPN6-A) psmd11a Danio rerio (Zebrafish) (Brachydanio rerio) 421 proteasome assembly [GO:0043248]; stem cell differentiation [GO:0048863]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005634; GO:0005829; GO:0006511; GO:0022624; GO:0043248; GO:0048863 0 0 0 PF01399; F6RIX4 CHOYP_MCM9.1.1 m.24676 sp MCM9_XENTR 61.153 659 246 4 42 693 17 672 0 858 MCM9_XENTR reviewed DNA helicase MCM9 (EC 3.6.4.12) (Minichromosome maintenance 9) mcm9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1117 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0006260; GO:0006974; GO:0097362 0 0 0 PF00493; F7E540 CHOYP_LOC100378590.1.1 m.6392 sp TTLL7_XENTR 49.637 826 356 13 74 848 42 858 0 803 TTLL7_XENTR reviewed Tubulin polyglutamylase TTLL7 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 7) ttll7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 909 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; protein polyglutamylation [GO:0018095] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0007399; GO:0018095; GO:0030154; GO:0030425; GO:0043204; GO:0070740 0 0 0 PF03133; F8WLE0 CHOYP_LOC100366906.1.1 m.61901 sp KIF28_RAT 38.558 874 466 22 4 855 15 839 0 582 KIF28_RAT reviewed Kinesin-like protein KIF28P (Kinesin-like protein 6) Kif28p Klp6 Rattus norvegicus (Rat) 1034 mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384] GO:0003777; GO:0005524; GO:0005622; GO:0005871; GO:0007005; GO:0016887; GO:0031966; GO:0072384 0 0 0 PF00498;PF12423;PF00225; F8WLE0 CHOYP_LOC100373911.1.1 m.48446 sp KIF28_RAT 43.457 1047 510 23 4 1003 15 1026 0 810 KIF28_RAT reviewed Kinesin-like protein KIF28P (Kinesin-like protein 6) Kif28p Klp6 Rattus norvegicus (Rat) 1034 mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384] GO:0003777; GO:0005524; GO:0005622; GO:0005871; GO:0007005; GO:0016887; GO:0031966; GO:0072384 0 0 0 PF00498;PF12423;PF00225; F8WLE0 CHOYP_NEMVEDRAFT_V1G100691.1.2 m.26774 sp KIF28_RAT 40.181 886 454 20 32 896 15 845 0 609 KIF28_RAT reviewed Kinesin-like protein KIF28P (Kinesin-like protein 6) Kif28p Klp6 Rattus norvegicus (Rat) 1034 mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384] GO:0003777; GO:0005524; GO:0005622; GO:0005871; GO:0007005; GO:0016887; GO:0031966; GO:0072384 0 0 0 PF00498;PF12423;PF00225; F8WLE0 CHOYP_NEMVEDRAFT_V1G100691.2.2 m.65547 sp KIF28_RAT 40.476 882 453 20 21 881 15 845 0 612 KIF28_RAT reviewed Kinesin-like protein KIF28P (Kinesin-like protein 6) Kif28p Klp6 Rattus norvegicus (Rat) 1034 mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384] GO:0003777; GO:0005524; GO:0005622; GO:0005871; GO:0007005; GO:0016887; GO:0031966; GO:0072384 0 0 0 PF00498;PF12423;PF00225; G3I6Z6 CHOYP_LOC100374755.1.3 m.8743 sp NOTC1_CRIGR 40.242 1404 786 26 491 1848 47 1443 0 976 NOTC1_CRIGR reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 2527 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000139; GO:0001525; GO:0004872; GO:0005509; GO:0005634; GO:0005796; GO:0005912; GO:0006351; GO:0006355; GO:0016021; GO:0016324; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; G3I6Z6 CHOYP_LOC100374755.2.3 m.8751 sp NOTC1_CRIGR 39.535 1462 814 28 491 1889 47 1501 0 978 NOTC1_CRIGR reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 2527 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000139; GO:0001525; GO:0004872; GO:0005509; GO:0005634; GO:0005796; GO:0005912; GO:0006351; GO:0006355; GO:0016021; GO:0016324; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; G3MWR8 CHOYP_MCA3A.1.2 m.24375 sp MICA3_BOVIN 53.01 947 372 21 9 917 12 923 0 961 MICA3_BOVIN reviewed Protein-methionine sulfoxide oxidase MICAL3 (EC 1.14.13.-) (Molecule interacting with CasL protein 3) (MICAL-3) MICAL3 Bos taurus (Bovine) 1960 actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; exocytosis [GO:0006887]; oxidation-reduction process [GO:0055114] GO:0003779; GO:0005634; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0006887; GO:0007010; GO:0008270; GO:0016709; GO:0030042; GO:0055114; GO:0071949 0 0 0 PF00307;PF12130;PF01494;PF00412; G3MWR8 CHOYP_MCA3A.2.2 m.43432 sp MICA3_BOVIN 53.102 951 375 22 9 927 12 923 0 955 MICA3_BOVIN reviewed Protein-methionine sulfoxide oxidase MICAL3 (EC 1.14.13.-) (Molecule interacting with CasL protein 3) (MICAL-3) MICAL3 Bos taurus (Bovine) 1960 actin filament depolymerization [GO:0030042]; cytoskeleton organization [GO:0007010]; exocytosis [GO:0006887]; oxidation-reduction process [GO:0055114] GO:0003779; GO:0005634; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0006887; GO:0007010; GO:0008270; GO:0016709; GO:0030042; GO:0055114; GO:0071949 0 0 0 PF00307;PF12130;PF01494;PF00412; G3UZ78 CHOYP_ADGB.2.3 m.50578 sp ADGB_MOUSE 37.411 1120 512 28 752 1775 617 1643 0 639 ADGB_MOUSE reviewed Androglobin (Calpain-7-like protein) Adgb Capn7l Mus musculus (Mouse) 1657 proteolysis [GO:0006508] GO:0004198; GO:0005737; GO:0006508; GO:0019825; GO:0020037 0 0 0 PF00648; G3UZ78 CHOYP_contig_013353 m.15297 sp ADGB_MOUSE 36.745 1143 511 28 780 1826 617 1643 0 631 ADGB_MOUSE reviewed Androglobin (Calpain-7-like protein) Adgb Capn7l Mus musculus (Mouse) 1657 proteolysis [GO:0006508] GO:0004198; GO:0005737; GO:0006508; GO:0019825; GO:0020037 0 0 0 PF00648; G3X9K3 CHOYP_BIG1.1.3 m.6444 sp BIG1_MOUSE 66.793 1846 470 19 1 1715 1 1834 0 2432 BIG1_MOUSE reviewed Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) Arfgef1 Mus musculus (Mouse) 1846 endomembrane system organization [GO:0010256]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; neuron projection development [GO:0031175]; positive regulation of protein glycosylation in Golgi [GO:0090284]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of wound healing [GO:0090303]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0005085; GO:0005086; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0007030; GO:0010256; GO:0015031; GO:0016192; GO:0016363; GO:0017022; GO:0030532; GO:0030837; GO:0031175; GO:0032012; GO:0034237; GO:0034260; GO:0048471; GO:0051897; GO:0090284; GO:0090303; GO:2000114 0 0 0 PF16213;PF09324;PF01369;PF12783; G4SLH0 CHOYP_LOC100367089.2.4 m.1911 sp TTN1_CAEEL 36.017 1205 671 24 2 1156 15626 16780 0 717 TTN1_CAEEL reviewed Titin homolog (EC 2.7.11.1) ttn-1 W06H8.8 Caenorhabditis elegans 18562 actin filament organization [GO:0007015]; sarcomere organization [GO:0045214]; striated muscle contraction [GO:0006941]; striated muscle myosin thick filament assembly [GO:0071688] GO:0004674; GO:0005524; GO:0005859; GO:0005865; GO:0006941; GO:0007015; GO:0008307; GO:0030018; GO:0031430; GO:0031672; GO:0031674; GO:0031965; GO:0045214; GO:0046872; GO:0051015; GO:0051371; GO:0071688; GO:0097493 0 0 0 PF00041;PF07679;PF00069; G5E870 CHOYP_TRIPC.1.1 m.6424 sp TRIPC_MOUSE 56.294 1835 709 24 145 1948 253 2025 0 2013 TRIPC_MOUSE reviewed E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12) Trip12 Mus musculus (Mouse) 2025 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; embryo development [GO:0009790]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006974; GO:0008270; GO:0009790; GO:0016874; GO:0042787; GO:0046966; GO:1901315; GO:2000780 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632;PF02825; G5E8K5 CHOYP_ANK.2.3 m.19487 sp ANK3_MOUSE 53.574 1609 666 14 19 1615 16 1555 0 1675 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; G5E8K5 CHOYP_LOC100907797.1.4 m.20027 sp ANK3_MOUSE 52 575 271 5 6 576 982 1555 0 629 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; G5E8K5 CHOYP_LOC100907797.2.4 m.28197 sp ANK3_MOUSE 51.458 583 273 5 1 580 980 1555 0 630 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; G5E8K5 CHOYP_LOC100907797.3.4 m.54169 sp ANK3_MOUSE 51.826 575 272 5 6 576 982 1555 0 624 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; H2A0L4 CHOYP_CHI1.1.1 m.40259 sp CHI1_PINMG 55.556 459 201 2 12 470 11 466 0 541 CHI1_PINMG reviewed Putative chitinase 1 (EC 3.2.1.14) (Chitinase-like protein 1) (Clp1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 468 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032] GO:0004568; GO:0005576; GO:0005975; GO:0006032 0 0 0 PF00704; H2A0M3 CHOYP_AMO.1.5 m.28337 sp AMO_PINMG 48.787 742 369 8 69 805 44 779 0 708 AMO_PINMG reviewed Putative amine oxidase [copper-containing] (EC 1.4.3.-) 0 Pinctada margaritifera (Black-lipped pearl oyster) 781 amine metabolic process [GO:0009308] GO:0005507; GO:0005576; GO:0008131; GO:0009308; GO:0048038 0 0 0 PF01179; H2A0M3 CHOYP_AMO.2.5 m.40128 sp AMO_PINMG 40.698 774 427 11 32 782 15 779 0 546 AMO_PINMG reviewed Putative amine oxidase [copper-containing] (EC 1.4.3.-) 0 Pinctada margaritifera (Black-lipped pearl oyster) 781 amine metabolic process [GO:0009308] GO:0005507; GO:0005576; GO:0008131; GO:0009308; GO:0048038 0 0 0 PF01179; H2LRU7 CHOYP_PKD2.3.3 m.54322 sp PKD2_ORYLA 41.366 805 438 13 28 815 103 890 0 648 PKD2_ORYLA reviewed Polycystin-2 (Polycystic kidney disease 2 protein homolog) pkd2 Oryzias latipes (Japanese rice fish) (Japanese killifish) 901 detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; ion transport [GO:0006811] GO:0003127; GO:0005509; GO:0005783; GO:0005929; GO:0006811; GO:0016021; GO:0050982; GO:0060170 0 0 0 PF08016; I0IUP3 CHOYP_LOC100377194.2.2 m.16183 sp MCM8_CHICK 61.832 786 283 6 70 842 48 829 0 1014 MCM8_CHICK reviewed DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) MCM8 RCJMB04_5o15 Gallus gallus (Chicken) 830 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; male gamete generation [GO:0048232] GO:0000724; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0006260; GO:0006974; GO:0007292; GO:0048232; GO:0097362 0 0 0 PF00493; M9NDE3 CHOYP_LOC657327.1.1 m.54811 sp BARK_DROME 30.62 2789 1646 80 81 2684 113 2797 0 1090 BARK_DROME reviewed Protein bark beetle (Protein anakonda) bark aka CG3921 Drosophila melanogaster (Fruit fly) 3123 "cell-cell junction maintenance [GO:0045217]; establishment of endothelial intestinal barrier [GO:0090557]; liquid clearance, open tracheal system [GO:0035002]; regulation of tube length, open tracheal system [GO:0035159]; response to endoplasmic reticulum stress [GO:0034976]; tricellular tight junction assembly [GO:1904274]" GO:0005044; GO:0005886; GO:0005912; GO:0005918; GO:0005923; GO:0016021; GO:0030246; GO:0034976; GO:0035002; GO:0035159; GO:0045217; GO:0061689; GO:0090557; GO:1904274 0 0 0 PF00530; O00267 CHOYP_SPT5H.1.1 m.60053 sp SPT5H_HUMAN 60.983 1038 331 24 85 1067 65 1083 0 1206 SPT5H_HUMAN reviewed Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) SUPT5H SPT5 SPT5H Homo sapiens (Human) 1087 "7-methylguanosine mRNA capping [GO:0006370]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA-templated transcription, elongation [GO:0006354]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of mRNA polyadenylation [GO:1900364]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; response to organic substance [GO:0010033]; single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0005634; GO:0005654; GO:0006338; GO:0006354; GO:0006366; GO:0006368; GO:0006370; GO:0007049; GO:0010033; GO:0016239; GO:0019899; GO:0032044; GO:0032785; GO:0032786; GO:0039692; GO:0044822; GO:0045944; GO:0046982; GO:0050434; GO:1900364 0 0 0 PF00467;PF03439;PF11942; O00291 CHOYP_HIP1.1.1 m.31791 sp HIP1_HUMAN 43.014 1095 507 18 7 1064 15 1029 0 827 HIP1_HUMAN reviewed Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) HIP1 Homo sapiens (Human) 1037 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell differentiation [GO:0030154]; clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005200; GO:0005634; GO:0005737; GO:0005794; GO:0005856; GO:0006351; GO:0006355; GO:0006915; GO:0006919; GO:0016020; GO:0030136; GO:0030154; GO:0030276; GO:0030665; GO:0035091; GO:0042981; GO:0043231; GO:0048260; GO:0048268; GO:0072583; GO:0097190 0 0 0 PF07651;PF16515;PF01608; O00329 CHOYP_PK3CD.1.1 m.53039 sp PK3CD_HUMAN 40.541 1073 567 22 1 1036 1 1039 0 732 PK3CD_HUMAN reviewed "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)" PIK3CD Homo sapiens (Human) 1044 adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; B cell chemotaxis [GO:0035754]; B cell receptor signaling pathway [GO:0050853]; cytokine production [GO:0001816]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; natural killer cell activation [GO:0030101]; natural killer cell chemotaxis [GO:0035747]; natural killer cell differentiation [GO:0001779]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; respiratory burst involved in defense response [GO:0002679]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] GO:0001779; GO:0001816; GO:0002250; GO:0002551; GO:0002679; GO:0005524; GO:0005829; GO:0005886; GO:0005942; GO:0006468; GO:0006661; GO:0006954; GO:0007165; GO:0010628; GO:0010818; GO:0014065; GO:0014066; GO:0016303; GO:0030101; GO:0030217; GO:0030335; GO:0030593; GO:0035004; GO:0035005; GO:0035747; GO:0035754; GO:0042110; GO:0042113; GO:0042629; GO:0043303; GO:0045087; GO:0046934; GO:0048015; GO:0050852; GO:0050853; GO:0060374; GO:0072672 PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis. 0 0 PF00454;PF00792;PF02192;PF00794;PF00613; O00400 CHOYP_LOC100372110.1.1 m.11437 sp ACATN_HUMAN 56.691 538 210 5 29 547 12 545 0 580 ACATN_HUMAN reviewed Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1) SLC33A1 ACATN AT1 Homo sapiens (Human) 549 BMP signaling pathway [GO:0030509]; SMAD protein signal transduction [GO:0060395]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0000139; GO:0005789; GO:0005887; GO:0006810; GO:0008521; GO:0015295; GO:0016020; GO:0030509; GO:0055085; GO:0060395 0 0 0 PF13000; O00410 CHOYP_IPO5.1.1 m.25693 sp IPO5_HUMAN 59.066 1092 446 1 4 1095 7 1097 0 1380 IPO5_HUMAN reviewed Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5) IPO5 KPNB3 RANBP5 Homo sapiens (Human) 1097 "cellular response to amino acid stimulus [GO:0071230]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus, docking [GO:0000059]; protein import into nucleus, translocation [GO:0000060]; ribosomal protein import into nucleus [GO:0006610]; viral process [GO:0016032]" GO:0000059; GO:0000060; GO:0005095; GO:0005634; GO:0005643; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0006607; GO:0006610; GO:0008139; GO:0008536; GO:0008565; GO:0016020; GO:0016032; GO:0031965; GO:0034399; GO:0042307; GO:0043231; GO:0044822; GO:0071230 0 0 0 PF02985; O00423 CHOYP_EMAL1.1.1 m.58030 sp EMAL1_HUMAN 52.121 825 350 10 49 870 33 815 0 870 EMAL1_HUMAN reviewed Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) EML1 EMAP1 EMAPL EMAPL1 Homo sapiens (Human) 815 brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405] GO:0000226; GO:0002244; GO:0005509; GO:0005829; GO:0005874; GO:0005875; GO:0007052; GO:0007405; GO:0007420; GO:0008017; GO:0015631; GO:0048471; GO:0097431; GO:1990023 0 0 0 PF03451;PF00400; O00423 CHOYP_EML1.1.1 m.18961 sp EMAL1_HUMAN 52.97 808 321 12 49 822 33 815 0 870 EMAL1_HUMAN reviewed Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1) EML1 EMAP1 EMAPL EMAPL1 Homo sapiens (Human) 815 brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405] GO:0000226; GO:0002244; GO:0005509; GO:0005829; GO:0005874; GO:0005875; GO:0007052; GO:0007405; GO:0007420; GO:0008017; GO:0015631; GO:0048471; GO:0097431; GO:1990023 0 0 0 PF03451;PF00400; O00462 CHOYP_MANBA.2.2 m.47433 sp MANBA_HUMAN 42.53 917 462 19 15 919 16 879 0 730 MANBA_HUMAN reviewed Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) MANBA MANB1 Homo sapiens (Human) 879 carbohydrate metabolic process [GO:0005975]; cellular protein modification process [GO:0006464]; oligosaccharide catabolic process [GO:0009313] GO:0004567; GO:0005537; GO:0005975; GO:0006464; GO:0009313; GO:0043202; GO:0043231 PATHWAY: Glycan metabolism; N-glycan degradation. 0 0 PF02836; O00471 CHOYP_BRAFLDRAFT_125658.1.1 m.27104 sp EXOC5_HUMAN 51.904 709 328 7 5 710 6 704 0 747 EXOC5_HUMAN reviewed Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) EXOC5 SEC10 SEC10L1 Homo sapiens (Human) 708 exocytosis [GO:0006887]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; vesicle docking [GO:0048278] GO:0005737; GO:0005829; GO:0006887; GO:0006892; GO:0015031; GO:0017160; GO:0048278 0 0 0 PF07393; O00548 CHOYP_BRAFLDRAFT_123438.1.2 m.11745 sp DLL1_HUMAN 39.575 753 382 12 23 758 18 714 0 542 DLL1_HUMAN reviewed Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1) DLL1 UNQ146/PRO172 Homo sapiens (Human) 723 astrocyte development [GO:0014002]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; cerebellar molecular layer formation [GO:0021688]; cerebellar Purkinje cell layer structural organization [GO:0021693]; clathrin-mediated endocytosis [GO:0072583]; compartment pattern specification [GO:0007386]; determination of left/right symmetry [GO:0007368]; endothelial tip cell fate specification [GO:0097102]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; inner ear development [GO:0048839]; lateral inhibition [GO:0046331]; left/right axis specification [GO:0070986]; loop of Henle development [GO:0072070]; marginal zone B cell differentiation [GO:0002315]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of neuron differentiation [GO:0045665]; nephron development [GO:0072006]; neuronal stem cell population maintenance [GO:0097150]; neuron fate specification [GO:0048665]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in arterial endothelial cell fate commitment [GO:0060853]; organ growth [GO:0035265]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proximal/distal pattern formation [GO:0009954]; proximal tubule development [GO:0072014]; regulation of blood pressure [GO:0008217]; regulation of cell adhesion [GO:0030155]; regulation of cell division [GO:0051302]; regulation of energy homeostasis [GO:2000505]; regulation of growth [GO:0040008]; regulation of neurogenesis [GO:0050767]; regulation of skeletal muscle tissue growth [GO:0048631]; regulation of somitogenesis [GO:0014807]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]; retina development in camera-type eye [GO:0060041]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle tissue growth [GO:0048630]; skin epidermis development [GO:0098773]; somite specification [GO:0001757]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; type B pancreatic cell development [GO:0003323] GO:0001709; GO:0001756; GO:0001757; GO:0001947; GO:0002315; GO:0003323; GO:0005112; GO:0005509; GO:0005576; GO:0005886; GO:0005887; GO:0005912; GO:0007219; GO:0007220; GO:0007368; GO:0007386; GO:0008217; GO:0008284; GO:0008285; GO:0009954; GO:0014002; GO:0014807; GO:0016324; GO:0021510; GO:0021688; GO:0021693; GO:0030097; GO:0030154; GO:0030155; GO:0030857; GO:0030957; GO:0031410; GO:0032693; GO:0034351; GO:0035265; GO:0040008; GO:0045121; GO:0045596; GO:0045605; GO:0045608; GO:0045638; GO:0045662; GO:0045665; GO:0045747; GO:0045807; GO:0045944; GO:0046331; GO:0048630; GO:0048631; GO:0048633; GO:0048665; GO:0048839; GO:0050767; GO:0051302; GO:0060041; GO:0060042; GO:0060853; GO:0070986; GO:0072006; GO:0072014; GO:0072070; GO:0072583; GO:0097102; GO:0097150; GO:0098773; GO:1900746; GO:1903672; GO:2000505 0 0 0 PF01414;PF00008;PF12661;PF07657; O00567 CHOYP_NOP56.1.1 m.55664 sp NOP56_HUMAN 68.879 437 134 1 15 451 4 438 0 657 NOP56_HUMAN reviewed Nucleolar protein 56 (Nucleolar protein 5A) NOP56 NOL5A Homo sapiens (Human) 594 rRNA modification [GO:0000154]; rRNA processing [GO:0006364] GO:0000154; GO:0003723; GO:0005654; GO:0005730; GO:0005732; GO:0005737; GO:0005913; GO:0006364; GO:0016020; GO:0030515; GO:0031428; GO:0032040; GO:0044822; GO:0070761; GO:0098641; GO:1990226 0 0 0 PF01798;PF08156; O02373 CHOYP_BRAFLDRAFT_126506.1.1 m.60629 sp UGDH_DROME 67.083 480 152 1 16 495 2 475 0 697 UGDH_DROME reviewed UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22) (Protein sugarless) (Protein suppenkasper) sgl kiwi ska CG10072 Drosophila melanogaster (Fruit fly) 476 "carbohydrate metabolic process [GO:0005975]; cell surface receptor signaling pathway [GO:0007166]; chondroitin sulfate biosynthetic process [GO:0030206]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heart development [GO:0007507]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; imaginal disc-derived wing morphogenesis [GO:0007476]; inter-male aggressive behavior [GO:0002121]; mesoderm migration involved in gastrulation [GO:0007509]; mushroom body development [GO:0016319]; olfactory behavior [GO:0042048]; primary branching, open tracheal system [GO:0007428]; segment polarity determination [GO:0007367]; smoothened signaling pathway [GO:0007224]; UDP-glucuronate biosynthetic process [GO:0006065]; Wnt signaling pathway [GO:0016055]" GO:0002121; GO:0003979; GO:0005634; GO:0005829; GO:0005975; GO:0006024; GO:0006065; GO:0007166; GO:0007224; GO:0007367; GO:0007427; GO:0007428; GO:0007476; GO:0007507; GO:0007509; GO:0008543; GO:0015012; GO:0015014; GO:0016055; GO:0016319; GO:0030206; GO:0042048; GO:0051287 PATHWAY: Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1. {ECO:0000269|PubMed:9217004}. 0 0 PF00984;PF03720;PF03721; O02649 CHOYP_CH60.1.1 m.26967 sp CH60_DROME 75.681 551 131 2 1 550 1 549 0 845 CH60_DROME reviewed "60 kDa heat shock protein, mitochondrial (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Mitochondrial matrix protein P1)" Hsp60 Mmp-P1 CG12101 Drosophila melanogaster (Fruit fly) 573 cellular response to heat [GO:0034605]; mitochondrion organization [GO:0007005]; protein refolding [GO:0042026]; sleep [GO:0030431] GO:0005524; GO:0005739; GO:0005743; GO:0005759; GO:0005811; GO:0005875; GO:0007005; GO:0030431; GO:0034605; GO:0042026 0 0 0 PF00118; O02654 CHOYP_ENO.1.2 m.7681 sp ENO_DORPE 82.639 432 75 0 1 432 1 432 0 739 ENO_DORPE reviewed Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 434 glycolytic process [GO:0006096] GO:0000015; GO:0000287; GO:0004634; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. 0 cd03313; PF00113;PF03952; O02654 CHOYP_ENO.2.2 m.23025 sp ENO_DORPE 82.639 432 75 0 1 432 1 432 0 739 ENO_DORPE reviewed Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 434 glycolytic process [GO:0006096] GO:0000015; GO:0000287; GO:0004634; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. 0 cd03313; PF00113;PF03952; O02695 CHOYP_LOC100865286.1.1 m.17958 sp PTPR2_MACNE 64.027 442 144 5 543 973 576 1013 0 563 PTPR2_MACNE reviewed Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.48) (M1851) PTPRN2 Macaca nemestrina (Pig-tailed macaque) 1013 insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; neurotransmitter secretion [GO:0007269] GO:0004725; GO:0007269; GO:0016021; GO:0030054; GO:0030667; GO:0030672; GO:0035773 0 0 0 PF11548;PF14948;PF00102; O02768 CHOYP_PGH2.2.2 m.39367 sp PGH2_RABIT 57.092 557 235 4 18 571 15 570 0 690 PGH2_RABIT reviewed Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX-2 COX2 Oryctolagus cuniculus (Rabbit) 604 brown fat cell differentiation [GO:0050873]; cellular response to fluid shear stress [GO:0071498]; cellular response to hypoxia [GO:0071456]; cyclooxygenase pathway [GO:0019371]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of fever generation [GO:0031622]; prostaglandin biosynthetic process [GO:0001516]; regulation of blood pressure [GO:0008217]; regulation of cell proliferation [GO:0042127]; response to oxidative stress [GO:0006979] GO:0001516; GO:0004601; GO:0004666; GO:0005634; GO:0005737; GO:0005789; GO:0006954; GO:0006979; GO:0007566; GO:0008217; GO:0019371; GO:0020037; GO:0031090; GO:0031622; GO:0042127; GO:0043005; GO:0046697; GO:0046872; GO:0050873; GO:0051213; GO:0071456; GO:0071498; GO:0090336 PATHWAY: Lipid metabolism; prostaglandin biosynthesis. 0 0 PF03098;PF00008; O08560 CHOYP_DGKZA.1.2 m.29620 sp DGKZ_RAT 61.79 704 254 6 32 721 53 755 0 911 DGKZ_RAT reviewed Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (104 kDa diacylglycerol kinase) (DGK-IV) (Diglyceride kinase zeta) (DGK-zeta) Dgkz Dagk6 Rattus norvegicus (Rat) 929 intracellular signal transduction [GO:0035556]; mitotic G1 DNA damage checkpoint [GO:0031571]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205] GO:0001727; GO:0004143; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007205; GO:0030027; GO:0031571; GO:0035556; GO:0046872 0 0 0 PF12796;PF00130;PF00609;PF00781; O08582 CHOYP_GTPB1.1.1 m.66453 sp GTPB1_MOUSE 71.481 547 147 4 8 551 48 588 0 805 GTPB1_MOUSE reviewed GTP-binding protein 1 (G-protein 1) (GP-1) (GP1) Gtpbp1 Gtpbp Mus musculus (Mouse) 668 positive regulation of mRNA catabolic process [GO:0061014]; translational elongation [GO:0006414] GO:0000177; GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005829; GO:0006414; GO:0016020; GO:0044822; GO:0061014 0 0 0 0 O08654 CHOYP_BRAFLDRAFT_236516.1.1 m.57732 sp CP070_RAT 62.53 419 142 4 1 414 1 409 0 540 CP070_RAT reviewed UPF0183 protein C16orf70 homolog 0 Rattus norvegicus (Rat) 422 Golgi to plasma membrane protein transport [GO:0043001] GO:0005802; GO:0016020; GO:0030165; GO:0030425; GO:0030672; GO:0035254; GO:0043001 0 0 0 PF03676; O08662 CHOYP_ISCW_ISCW015061.1.1 m.51 sp PI4KA_RAT 49.387 2120 960 30 23 2084 32 2096 0 1990 PI4KA_RAT reviewed Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) Pi4ka Pik4ca Rattus norvegicus (Rat) 2096 phosphatidylinositol-mediated signaling [GO:0048015] GO:0004430; GO:0005524; GO:0005886; GO:0030660; GO:0048015 0 0 0 PF00454;PF00613; O08662 CHOYP_PI4KA.1.1 m.52506 sp PI4KA_RAT 48.914 2118 941 30 1 2060 62 2096 0 1961 PI4KA_RAT reviewed Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) Pi4ka Pik4ca Rattus norvegicus (Rat) 2096 phosphatidylinositol-mediated signaling [GO:0048015] GO:0004430; GO:0005524; GO:0005886; GO:0030660; GO:0048015 0 0 0 PF00454;PF00613; O08663 CHOYP_LOC100367137.1.1 m.23977 sp MAP2_MOUSE 77.358 371 84 0 124 494 108 478 0 625 MAP2_MOUSE reviewed Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) Metap2 Mnpep P67eif2 Mus musculus (Mouse) 478 N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; protein initiator methionine removal [GO:0070084]; protein processing [GO:0016485] GO:0004177; GO:0005737; GO:0005886; GO:0008235; GO:0016485; GO:0018206; GO:0031365; GO:0044822; GO:0046872; GO:0070006; GO:0070084 0 0 cd01088; PF00557; O08663 CHOYP_MVP.1.1 m.56231 sp MAP2_MOUSE 77.628 371 83 0 95 465 108 478 0 626 MAP2_MOUSE reviewed Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) Metap2 Mnpep P67eif2 Mus musculus (Mouse) 478 N-terminal protein amino acid modification [GO:0031365]; peptidyl-methionine modification [GO:0018206]; protein initiator methionine removal [GO:0070084]; protein processing [GO:0016485] GO:0004177; GO:0005737; GO:0005886; GO:0008235; GO:0016485; GO:0018206; GO:0031365; GO:0044822; GO:0046872; GO:0070006; GO:0070084 0 0 cd01088; PF00557; O08688 CHOYP_CAPN5.1.1 m.463 sp CAN5_MOUSE 46.321 598 296 8 4 584 5 594 0 547 CAN5_MOUSE reviewed Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) Capn5 Ncl3 Mus musculus (Mouse) 640 granulosa cell differentiation [GO:0060014]; luteinization [GO:0001553]; ovarian follicle development [GO:0001541]; proteolysis [GO:0006508] GO:0001541; GO:0001553; GO:0004198; GO:0005737; GO:0005925; GO:0006508; GO:0009986; GO:0060014; GO:0070062 0 0 0 PF01067;PF00648; O08688 CHOYP_LOC100543709.1.1 m.32086 sp CAN5_MOUSE 44.923 650 335 10 24 660 1 640 0 575 CAN5_MOUSE reviewed Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) Capn5 Ncl3 Mus musculus (Mouse) 640 granulosa cell differentiation [GO:0060014]; luteinization [GO:0001553]; ovarian follicle development [GO:0001541]; proteolysis [GO:0006508] GO:0001541; GO:0001553; GO:0004198; GO:0005737; GO:0005925; GO:0006508; GO:0009986; GO:0060014; GO:0070062 0 0 0 PF01067;PF00648; O08688 CHOYP_LOC101061191.1.1 m.8584 sp CAN5_MOUSE 44.838 649 334 10 5 638 1 640 0 567 CAN5_MOUSE reviewed Calpain-5 (EC 3.4.22.-) (New calpain 3) (nCL-3) Capn5 Ncl3 Mus musculus (Mouse) 640 granulosa cell differentiation [GO:0060014]; luteinization [GO:0001553]; ovarian follicle development [GO:0001541]; proteolysis [GO:0006508] GO:0001541; GO:0001553; GO:0004198; GO:0005737; GO:0005925; GO:0006508; GO:0009986; GO:0060014; GO:0070062 0 0 0 PF01067;PF00648; O08811 CHOYP_ERCC2.1.1 m.14200 sp ERCC2_MOUSE 74.625 733 185 1 1 733 1 732 0 1200 ERCC2_MOUSE reviewed TFIIH basal transcription factor complex helicase XPD subunit (EC 3.6.4.12) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) Ercc2 Xpd Mus musculus (Mouse) 760 "aging [GO:0007568]; apoptotic process [GO:0006915]; bone mineralization [GO:0030282]; cell proliferation [GO:0008283]; central nervous system myelin formation [GO:0032289]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; embryonic cleavage [GO:0040016]; erythrocyte maturation [GO:0043249]; extracellular matrix organization [GO:0030198]; hair cell differentiation [GO:0035315]; hair cycle process [GO:0022405]; hair follicle maturation [GO:0048820]; hematopoietic stem cell differentiation [GO:0060218]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA incision [GO:0033683]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; skin development [GO:0043588]; spinal cord development [GO:0021510]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription from RNA polymerase II promoter [GO:0006366]; UV protection [GO:0009650]" GO:0000439; GO:0001666; GO:0001701; GO:0003677; GO:0004003; GO:0005524; GO:0005634; GO:0005675; GO:0005737; GO:0005819; GO:0006281; GO:0006283; GO:0006289; GO:0006366; GO:0006915; GO:0006979; GO:0007059; GO:0007568; GO:0008022; GO:0008283; GO:0008353; GO:0009411; GO:0009650; GO:0009791; GO:0019907; GO:0021510; GO:0022405; GO:0030198; GO:0030282; GO:0032289; GO:0033683; GO:0035264; GO:0035315; GO:0040016; GO:0043139; GO:0043249; GO:0043388; GO:0043588; GO:0045893; GO:0045944; GO:0046872; GO:0047485; GO:0048820; GO:0051539; GO:0060218; GO:0071817; GO:1901990 0 0 0 PF06733;PF06777;PF13307; O08837 CHOYP_CDC5L.1.1 m.25107 sp CDC5L_RAT 68.159 804 238 7 1 792 1 798 0 1065 CDC5L_RAT reviewed Cell division cycle 5-like protein (Cdc5-like protein) (Pombe Cdc5-related protein) Cdc5l Pcdc5rp Rattus norvegicus (Rat) 802 "cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-2 [GO:0071352]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to prolactin [GO:1990646]; cellular response to wortmannin [GO:1904568]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; signal transduction involved in DNA damage checkpoint [GO:0072422]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0000278; GO:0000974; GO:0001222; GO:0003677; GO:0005634; GO:0005662; GO:0005730; GO:0006281; GO:0006351; GO:0006355; GO:0006397; GO:0008157; GO:0008380; GO:0016020; GO:0016607; GO:0019901; GO:0032993; GO:0043522; GO:0044344; GO:0044822; GO:0048471; GO:0071013; GO:0071352; GO:0071987; GO:0072422; GO:1904568; GO:1990090; GO:1990646 0 0 0 PF11831; O08837 CHOYP_EF2.3.5 m.28898 sp CDC5L_RAT 67.737 654 193 7 1 642 1 648 0 844 CDC5L_RAT reviewed Cell division cycle 5-like protein (Cdc5-like protein) (Pombe Cdc5-related protein) Cdc5l Pcdc5rp Rattus norvegicus (Rat) 802 "cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to interleukin-2 [GO:0071352]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to prolactin [GO:1990646]; cellular response to wortmannin [GO:1904568]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; signal transduction involved in DNA damage checkpoint [GO:0072422]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0000278; GO:0000974; GO:0001222; GO:0003677; GO:0005634; GO:0005662; GO:0005730; GO:0006281; GO:0006351; GO:0006355; GO:0006397; GO:0008157; GO:0008380; GO:0016020; GO:0016607; GO:0019901; GO:0032993; GO:0043522; GO:0044344; GO:0044822; GO:0048471; GO:0071013; GO:0071352; GO:0071987; GO:0072422; GO:1904568; GO:1990090; GO:1990646 0 0 0 PF11831; O08873 CHOYP_MADD.1.3 m.20153 sp MADD_RAT 57.185 675 246 6 1 637 1 670 0 769 MADD_RAT reviewed MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) Madd Rattus norvegicus (Rat) 1602 activation of MAPK activity [GO:0000187]; apoptotic process [GO:0006915]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of pancreatic amylase secretion [GO:1902277]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041] GO:0000187; GO:0005634; GO:0005829; GO:0006915; GO:0008021; GO:0016021; GO:0017112; GO:0045202; GO:0051726; GO:0060125; GO:1902041; GO:1902277 0 0 0 PF02141;PF03456; O08873 CHOYP_MADD.2.3 m.37888 sp MADD_RAT 55.897 619 231 5 1 581 56 670 0 677 MADD_RAT reviewed MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) Madd Rattus norvegicus (Rat) 1602 activation of MAPK activity [GO:0000187]; apoptotic process [GO:0006915]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of pancreatic amylase secretion [GO:1902277]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041] GO:0000187; GO:0005634; GO:0005829; GO:0006915; GO:0008021; GO:0016021; GO:0017112; GO:0045202; GO:0051726; GO:0060125; GO:1902041; GO:1902277 0 0 0 PF02141;PF03456; O08873 CHOYP_MADD.3.3 m.62035 sp MADD_RAT 57.185 675 246 6 1 637 1 670 0 768 MADD_RAT reviewed MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) Madd Rattus norvegicus (Rat) 1602 activation of MAPK activity [GO:0000187]; apoptotic process [GO:0006915]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of pancreatic amylase secretion [GO:1902277]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041] GO:0000187; GO:0005634; GO:0005829; GO:0006915; GO:0008021; GO:0016021; GO:0017112; GO:0045202; GO:0051726; GO:0060125; GO:1902041; GO:1902277 0 0 0 PF02141;PF03456; O08912 CHOYP_GLT13.2.2 m.10604 sp GALT1_MOUSE 61.93 570 194 8 6 571 3 553 0 736 GALT1_MOUSE reviewed Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] Galnt1 Mus musculus (Mouse) 559 protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] GO:0004653; GO:0005576; GO:0006493; GO:0016020; GO:0016021; GO:0018242; GO:0018243; GO:0030145; GO:0030246; GO:0032580; GO:0048471 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; O09012 CHOYP_PEX5.1.2 m.44602 sp PEX5_MOUSE 52.201 636 250 18 37 635 19 637 0 585 PEX5_MOUSE reviewed Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (PXR1P) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) Pex5 Pxr1 Mus musculus (Mouse) 639 "cell development [GO:0048468]; cellular lipid metabolic process [GO:0044255]; cerebral cortex cell migration [GO:0021795]; cerebral cortex neuron differentiation [GO:0021895]; endoplasmic reticulum organization [GO:0007029]; fatty acid beta-oxidation [GO:0006635]; mitochondrial membrane organization [GO:0007006]; mitochondrion organization [GO:0007005]; negative regulation of protein homotetramerization [GO:1901094]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; positive regulation of multicellular organism growth [GO:0040018]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; very long-chain fatty acid metabolic process [GO:0000038]" GO:0000038; GO:0000268; GO:0001764; GO:0005052; GO:0005622; GO:0005737; GO:0005739; GO:0005777; GO:0005778; GO:0005829; GO:0006625; GO:0006635; GO:0007005; GO:0007006; GO:0007029; GO:0007031; GO:0008022; GO:0016020; GO:0016558; GO:0016560; GO:0019899; GO:0021795; GO:0021895; GO:0031267; GO:0040018; GO:0043234; GO:0044255; GO:0045046; GO:0047485; GO:0048468; GO:0050905; GO:1901094 0 0 0 PF13374; O09012 CHOYP_PEX5.2.2 m.53017 sp PEX5_MOUSE 50.932 644 241 15 1 576 1 637 0 581 PEX5_MOUSE reviewed Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (PXR1P) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) Pex5 Pxr1 Mus musculus (Mouse) 639 "cell development [GO:0048468]; cellular lipid metabolic process [GO:0044255]; cerebral cortex cell migration [GO:0021795]; cerebral cortex neuron differentiation [GO:0021895]; endoplasmic reticulum organization [GO:0007029]; fatty acid beta-oxidation [GO:0006635]; mitochondrial membrane organization [GO:0007006]; mitochondrion organization [GO:0007005]; negative regulation of protein homotetramerization [GO:1901094]; neuromuscular process [GO:0050905]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; positive regulation of multicellular organism growth [GO:0040018]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; very long-chain fatty acid metabolic process [GO:0000038]" GO:0000038; GO:0000268; GO:0001764; GO:0005052; GO:0005622; GO:0005737; GO:0005739; GO:0005777; GO:0005778; GO:0005829; GO:0006625; GO:0006635; GO:0007005; GO:0007006; GO:0007029; GO:0007031; GO:0008022; GO:0016020; GO:0016558; GO:0016560; GO:0019899; GO:0021795; GO:0021895; GO:0031267; GO:0040018; GO:0043234; GO:0044255; GO:0045046; GO:0047485; GO:0048468; GO:0050905; GO:1901094 0 0 0 PF13374; O12944 CHOYP_BRAFLDRAFT_281964.1.1 m.49043 sp RAD54_CHICK 72.543 692 186 3 41 730 41 730 0 1026 RAD54_CHICK reviewed DNA repair and recombination protein RAD54-like (EC 3.6.4.-) (Putative recombination factor GdRad54) (RAD54 homolog) (Fragment) RAD54L RAD54 Gallus gallus (Chicken) 733 DNA repair [GO:0006281] GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0006281; GO:0036310 0 0 0 PF00271;PF00176; O13046 CHOYP_WDHD1.1.1 m.23505 sp WDHD1_XENLA 40.203 1082 553 18 26 1016 8 1086 0 803 WDHD1_XENLA reviewed WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) wdhd1 Xenopus laevis (African clawed frog) 1127 0 GO:0003677; GO:0005654; GO:0005737 0 0 0 PF08662;PF00505;PF12341;PF00400; O14522 CHOYP_PTPRK.2.20 m.1585 sp PTPRT_HUMAN 34.142 1072 625 23 434 1444 389 1440 0 606 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14522 CHOYP_PTPRK.3.20 m.2181 sp PTPRT_HUMAN 34.142 1072 625 22 532 1542 389 1440 0 606 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14522 CHOYP_PTPRK.5.20 m.4426 sp PTPRT_HUMAN 34.142 1072 625 23 581 1591 389 1440 0 607 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14522 CHOYP_PTPRT.36.45 m.57372 sp PTPRT_HUMAN 33.959 1066 604 22 581 1560 389 1440 0 601 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14744 CHOYP_ANM5.1.1 m.1529 sp ANM5_HUMAN 59.365 630 250 3 6 633 12 637 0 795 ANM5_HUMAN reviewed "Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]" PRMT5 HRMT1L5 IBP72 JBP1 SKB1 Homo sapiens (Human) 637 "cell proliferation [GO:0008283]; circadian regulation of gene expression [GO:0032922]; DNA-templated transcription, termination [GO:0006353]; endothelial cell activation [GO:0042118]; Golgi ribbon formation [GO:0090161]; histone H4-R3 methylation [GO:0043985]; liver regeneration [GO:0097421]; negative regulation of cell differentiation [GO:0045596]; peptidyl-arginine methylation [GO:0018216]; peptidyl-arginine N-methylation [GO:0035246]; positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:1904992]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA methylation [GO:0044030]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of mitotic nuclear division [GO:0007088]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; spliceosomal snRNP assembly [GO:0000387]" GO:0000387; GO:0001046; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006353; GO:0006355; GO:0007088; GO:0008168; GO:0008283; GO:0008327; GO:0008469; GO:0016274; GO:0018216; GO:0032922; GO:0034709; GO:0035097; GO:0035243; GO:0035246; GO:0042118; GO:0043021; GO:0043985; GO:0044020; GO:0044030; GO:0045596; GO:0046982; GO:0048714; GO:0070372; GO:0090161; GO:0097421; GO:1901796; GO:1904992 0 0 0 PF05185; O14757 CHOYP_LOC100367549.1.1 m.6366 sp CHK1_HUMAN 56.867 466 197 3 7 471 5 467 0 534 CHK1_HUMAN reviewed Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1) CHEK1 CHK1 Homo sapiens (Human) 476 cellular response to DNA damage stimulus [GO:0006974]; cellular response to mechanical stimulus [GO:0071260]; chromatin-mediated maintenance of transcription [GO:0048096]; DNA damage checkpoint [GO:0000077]; DNA damage induced protein phosphorylation [GO:0006975]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; G2/M transition of mitotic cell cycle [GO:0000086]; G2 DNA damage checkpoint [GO:0031572]; negative regulation of mitotic nuclear division [GO:0045839]; peptidyl-threonine phosphorylation [GO:0018107]; regulation of cell proliferation [GO:0042127]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of histone H3-K9 acetylation [GO:2000615]; regulation of mitotic centrosome separation [GO:0046602]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [GO:0010767]; replicative senescence [GO:0090399] GO:0000077; GO:0000086; GO:0000785; GO:0000794; GO:0004672; GO:0004674; GO:0005524; GO:0005615; GO:0005634; GO:0005654; GO:0005657; GO:0005813; GO:0005829; GO:0006260; GO:0006281; GO:0006974; GO:0006975; GO:0010569; GO:0010767; GO:0016301; GO:0018107; GO:0031572; GO:0035402; GO:0042127; GO:0043231; GO:0045839; GO:0046602; GO:0048096; GO:0071260; GO:0090399; GO:1901796; GO:2000615 0 0 0 PF00069; O14841 CHOYP_BRAFLDRAFT_214348.1.2 m.42797 sp OPLA_HUMAN 64.247 1295 448 3 5 1299 8 1287 0 1683 OPLA_HUMAN reviewed 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) OPLAH Homo sapiens (Human) 1288 glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749] GO:0005524; GO:0005829; GO:0006749; GO:0006750; GO:0017168 0 0 0 PF05378;PF01968;PF02538; O14936 CHOYP_CSKP.1.2 m.20832 sp CSKP_HUMAN 63.816 959 275 13 1 920 1 926 0 1224 CSKP_HUMAN reviewed Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) CASK LIN2 Homo sapiens (Human) 926 calcium ion import [GO:0070509]; cell adhesion [GO:0007155]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; neurotransmitter secretion [GO:0007269]; positive regulation of calcium ion import [GO:0090280]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001953; GO:0004385; GO:0004674; GO:0005524; GO:0005604; GO:0005652; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007155; GO:0007269; GO:0010839; GO:0015629; GO:0016323; GO:0016363; GO:0031982; GO:0042734; GO:0045944; GO:0060170; GO:0061045; GO:0070509; GO:0090280; GO:0090288 0 0 0 PF00625;PF02828;PF00595;PF00069;PF07653; O14936 CHOYP_CSKP.2.2 m.33800 sp CSKP_HUMAN 65.106 940 274 12 1 900 1 926 0 1238 CSKP_HUMAN reviewed Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) CASK LIN2 Homo sapiens (Human) 926 calcium ion import [GO:0070509]; cell adhesion [GO:0007155]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of wound healing [GO:0061045]; neurotransmitter secretion [GO:0007269]; positive regulation of calcium ion import [GO:0090280]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001953; GO:0004385; GO:0004674; GO:0005524; GO:0005604; GO:0005652; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0007155; GO:0007269; GO:0010839; GO:0015629; GO:0016323; GO:0016363; GO:0031982; GO:0042734; GO:0045944; GO:0060170; GO:0061045; GO:0070509; GO:0090280; GO:0090288 0 0 0 PF00625;PF02828;PF00595;PF00069;PF07653; O14976 CHOYP_GAK.1.1 m.7017 sp GAK_HUMAN 44.264 1351 652 28 9 1307 10 1311 0 1074 GAK_HUMAN reviewed Cyclin-G-associated kinase (EC 2.7.11.1) GAK Homo sapiens (Human) 1311 cell cycle [GO:0007049]; clathrin coat disassembly [GO:0072318]; clathrin-mediated endocytosis [GO:0072583]; endoplasmic reticulum organization [GO:0007029]; establishment of protein localization to Golgi [GO:0072600]; establishment of protein localization to plasma membrane [GO:0090002]; Golgi organization [GO:0007030]; Golgi to lysosome transport [GO:0090160]; negative regulation of neuron projection development [GO:0010977]; receptor-mediated endocytosis [GO:0006898] GO:0004674; GO:0005524; GO:0005794; GO:0005829; GO:0005925; GO:0006898; GO:0007029; GO:0007030; GO:0007049; GO:0010977; GO:0016020; GO:0030332; GO:0031982; GO:0043231; GO:0048471; GO:0072318; GO:0072583; GO:0072600; GO:0090002; GO:0090160 0 0 cd06257; PF00069;PF10409; O14981 CHOYP_BTAF1.2.2 m.55086 sp BTAF1_HUMAN 55.425 1871 758 27 3 1822 4 1849 0 1997 BTAF1_HUMAN reviewed TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) BTAF1 TAF172 Homo sapiens (Human) 1849 "negative regulation of chromatin binding [GO:0035562]; negative regulation of transcription, DNA-templated [GO:0045892]" GO:0003677; GO:0003700; GO:0004386; GO:0005524; GO:0005654; GO:0035562; GO:0043231; GO:0045892 0 0 0 PF12054;PF00271;PF00176; O15050 CHOYP_BRAFLDRAFT_118709.2.4 m.41225 sp TRNK1_HUMAN 36.549 1617 885 35 294 1827 423 1981 0 953 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_LOC100514320.2.2 m.61967 sp TRNK1_HUMAN 37.746 1624 866 39 486 2024 349 1912 0 968 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRANK1.1.9 m.15854 sp TRNK1_HUMAN 31.725 2446 1422 68 1283 3606 423 2742 0 1049 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRANK1.2.9 m.20131 sp TRNK1_HUMAN 40.8 1250 643 23 1308 2511 783 1981 0 911 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRANK1.6.9 m.37010 sp TRNK1_HUMAN 33.205 2075 1180 57 1124 3107 783 2742 0 983 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRANK1.7.9 m.38891 sp TRNK1_HUMAN 33.373 1687 898 47 1283 2804 450 2075 0 783 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRANK1.8.9 m.44300 sp TRNK1_HUMAN 38.525 976 544 20 736 1701 1146 2075 0 620 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRNK1.1.6 m.53444 sp TRNK1_HUMAN 36.976 1098 575 27 7 1036 1027 2075 0 641 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRNK1.4.6 m.58602 sp TRNK1_HUMAN 44.017 702 353 12 1 699 1226 1890 0 580 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRNK1.6.6 m.64668 sp TRNK1_HUMAN 39.71 1448 754 29 4 1382 517 1914 0 941 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15066 CHOYP_KRP95.1.1 m.13582 sp KIF3B_HUMAN 66.755 755 239 3 1 751 1 747 0 971 KIF3B_HUMAN reviewed "Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed]" KIF3B KIAA0359 Homo sapiens (Human) 747 "anterograde axonal transport [GO:0008089]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; determination of left/right symmetry [GO:0007368]; microtubule-based movement [GO:0007018]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of cytokinesis [GO:0032467]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0003777; GO:0005524; GO:0005813; GO:0005819; GO:0005829; GO:0005873; GO:0005874; GO:0005929; GO:0006890; GO:0007018; GO:0007052; GO:0007100; GO:0007368; GO:0008089; GO:0008574; GO:0015630; GO:0016020; GO:0016939; GO:0017048; GO:0019886; GO:0030496; GO:0030990; GO:0032467; GO:0070062; GO:0072372; GO:0072383; GO:0090307; GO:0097542; GO:1904115 0 0 0 PF00225; O15067 CHOYP_BRAFLDRAFT_278091.1.1 m.7340 sp PUR4_HUMAN 57.038 1357 549 16 10 1355 1 1334 0 1544 PUR4_HUMAN reviewed Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) PFAS KIAA0361 Homo sapiens (Human) 1338 'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to drug [GO:0042493]; ribonucleoside monophosphate biosynthetic process [GO:0009156] GO:0004642; GO:0005524; GO:0005737; GO:0005829; GO:0006164; GO:0006189; GO:0006541; GO:0009156; GO:0009168; GO:0042493; GO:0046872; GO:0070062 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. 0 0 PF02769; O15078 CHOYP_CEP290.1.1 m.58767 sp CE290_HUMAN 41.942 2451 1312 25 226 2644 78 2449 0 1640 CE290_HUMAN reviewed Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) CEP290 BBS14 KIAA0373 NPHP6 Homo sapiens (Human) 2479 "cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; eye photoreceptor cell development [GO:0042462]; G2/M transition of mitotic cell cycle [GO:0000086]; hindbrain development [GO:0030902]; otic vesicle formation [GO:0030916]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of transcription, DNA-templated [GO:0045893]; pronephros development [GO:0048793]; protein transport [GO:0015031]; regulation of establishment of protein localization [GO:0070201]" GO:0000086; GO:0005634; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0015031; GO:0016020; GO:0030902; GO:0030916; GO:0032391; GO:0034451; GO:0035869; GO:0036038; GO:0042384; GO:0042462; GO:0042802; GO:0043234; GO:0045893; GO:0048793; GO:0060271; GO:0070201; GO:0090316 0 0 0 PF16574; O15084 CHOYP_LOC100370913.1.1 m.19909 sp ANR28_HUMAN 58.663 987 387 7 40 1009 1 983 0 1171 ANR28_HUMAN reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) 1053 COPII vesicle coating [GO:0048208] GO:0000139; GO:0005654; GO:0005829; GO:0048208 0 0 0 PF00023;PF12796; O15254 CHOYP_ACOX3.1.1 m.60111 sp ACOX3_HUMAN 56.566 693 293 5 35 723 12 700 0 824 ACOX3_HUMAN reviewed Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase) ACOX3 BRCOX PRCOX Homo sapiens (Human) 700 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; lipid homeostasis [GO:0055088] GO:0000062; GO:0003995; GO:0005102; GO:0005739; GO:0005777; GO:0005782; GO:0009055; GO:0016020; GO:0016402; GO:0033539; GO:0033540; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. 0 0 PF01756;PF02770; O15439 CHOYP_MRP4.1.3 m.6939 sp MRP4_HUMAN 53.216 1306 579 10 9 1304 9 1292 0 1398 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O15440 CHOYP_MRP5.1.3 m.10550 sp MRP5_HUMAN 50.042 1191 520 10 1 1158 283 1431 0 1215 MRP5_HUMAN reviewed Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) 1437 hyaluronan biosynthetic process [GO:0030213]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005524; GO:0005886; GO:0005887; GO:0006810; GO:0008514; GO:0016020; GO:0030213; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O15440 CHOYP_MRP5.3.3 m.51741 sp MRP5_HUMAN 43.226 967 473 11 53 987 78 1000 0 808 MRP5_HUMAN reviewed Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11) ABCC5 MRP5 Homo sapiens (Human) 1437 hyaluronan biosynthetic process [GO:0030213]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005524; GO:0005886; GO:0005887; GO:0006810; GO:0008514; GO:0016020; GO:0030213; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O15457 CHOYP_MSH4.1.1 m.47926 sp MSH4_HUMAN 57.633 583 245 2 335 917 156 736 0 717 MSH4_HUMAN reviewed MutS protein homolog 4 (hMSH4) MSH4 Homo sapiens (Human) 936 female gamete generation [GO:0007292]; mismatch repair [GO:0006298]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; synapsis [GO:0007129] GO:0000793; GO:0001541; GO:0003677; GO:0005524; GO:0005634; GO:0006298; GO:0007129; GO:0007131; GO:0007283; GO:0007292; GO:0030983 0 0 0 PF05188;PF05192;PF05190;PF00488; O15484 CHOYP_CAN5.1.1 m.42242 sp CAN5_HUMAN 48.998 649 312 8 4 643 2 640 0 642 CAN5_HUMAN reviewed Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3) CAPN5 NCL3 Homo sapiens (Human) 640 granulosa cell differentiation [GO:0060014]; luteinization [GO:0001553]; ovarian follicle development [GO:0001541]; signal transduction [GO:0007165] GO:0001541; GO:0001553; GO:0004198; GO:0005737; GO:0005925; GO:0007165; GO:0009986; GO:0060014; GO:0070062 0 0 0 PF01067;PF00648; O15484 CHOYP_LOC100554578.1.2 m.7421 sp CAN5_HUMAN 43.323 644 348 8 6 639 1 637 0 549 CAN5_HUMAN reviewed Calpain-5 (EC 3.4.22.-) (Calpain htra-3) (New calpain 3) (nCL-3) CAPN5 NCL3 Homo sapiens (Human) 640 granulosa cell differentiation [GO:0060014]; luteinization [GO:0001553]; ovarian follicle development [GO:0001541]; signal transduction [GO:0007165] GO:0001541; GO:0001553; GO:0004198; GO:0005737; GO:0005925; GO:0007165; GO:0009986; GO:0060014; GO:0070062 0 0 0 PF01067;PF00648; O15550 CHOYP_LOC100883412.1.1 m.25657 sp KDM6A_HUMAN 55.244 677 253 15 576 1216 737 1399 0 705 KDM6A_HUMAN reviewed Lysine-specific demethylase 6A (EC 1.14.11.-) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) KDM6A UTX Homo sapiens (Human) 1401 canonical Wnt signaling pathway [GO:0060070]; heart morphogenesis [GO:0003007]; histone H3-K4 methylation [GO:0051568]; in utero embryonic development [GO:0001701]; mesodermal cell differentiation [GO:0048333]; multicellular organism growth [GO:0035264]; neural tube closure [GO:0001843]; notochord morphogenesis [GO:0048570]; positive regulation of gene expression [GO:0010628]; respiratory system process [GO:0003016]; somite rostral/caudal axis specification [GO:0032525] GO:0000978; GO:0001701; GO:0001843; GO:0003007; GO:0003016; GO:0005634; GO:0005654; GO:0010628; GO:0031490; GO:0032452; GO:0032525; GO:0035097; GO:0035264; GO:0044666; GO:0046872; GO:0048333; GO:0048570; GO:0051213; GO:0051568; GO:0060070; GO:0071558 0 0 0 PF02373;PF13181; O15943 CHOYP_CADN.1.3 m.9755 sp CADN_DROME 34.178 2961 1653 101 122 2941 281 3086 0 1363 CADN_DROME reviewed Neural-cadherin (Cadherin-N) (dN-cadherin) CadN CG7100 Drosophila melanogaster (Fruit fly) 3097 axonal fasciculation [GO:0007413]; axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of pain [GO:0019233] GO:0004872; GO:0005509; GO:0005886; GO:0005887; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0008013; GO:0016021; GO:0016318; GO:0016339; GO:0019233; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0050839 0 0 0 PF00028;PF01049;PF00008;PF02210; O15943 CHOYP_CADN.2.3 m.19237 sp CADN_DROME 35.918 2773 1548 87 255 2915 428 3083 0 1336 CADN_DROME reviewed Neural-cadherin (Cadherin-N) (dN-cadherin) CadN CG7100 Drosophila melanogaster (Fruit fly) 3097 axonal fasciculation [GO:0007413]; axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of pain [GO:0019233] GO:0004872; GO:0005509; GO:0005886; GO:0005887; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0008013; GO:0016021; GO:0016318; GO:0016339; GO:0019233; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0050839 0 0 0 PF00028;PF01049;PF00008;PF02210; O15945 CHOYP_ARNT.1.1 m.19078 sp ARNT_DROME 69.87 385 109 4 77 456 8 390 0 579 ARNT_DROME reviewed Aryl hydrocarbon receptor nuclear translocator homolog (dARNT) (Hypoxia-inducible factor 1-beta) (Protein tango) tgo ARNT HIF-1-beta CG11987 Drosophila melanogaster (Fruit fly) 642 "brain development [GO:0007420]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; central nervous system development [GO:0007417]; dendrite morphogenesis [GO:0048813]; epithelial cell fate determination, open tracheal system [GO:0007425]; glial cell migration [GO:0008347]; limb development [GO:0060173]; muscle organ development [GO:0007517]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of R7 cell differentiation [GO:0045676]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0000981; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006355; GO:0006357; GO:0006366; GO:0007417; GO:0007420; GO:0007422; GO:0007424; GO:0007425; GO:0007517; GO:0008347; GO:0017022; GO:0032869; GO:0043234; GO:0043565; GO:0045676; GO:0045944; GO:0046982; GO:0048477; GO:0048666; GO:0048813; GO:0060173; GO:0071456 0 0 0 PF00010;PF00989; O15975 CHOYP_GNAQ.1.1 m.20698 sp GNAQ_MIZYE 86.686 353 47 0 1 353 1 353 0 644 GNAQ_MIZYE reviewed Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q) SCGQA Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 353 G-protein coupled receptor signaling pathway [GO:0007186] GO:0003924; GO:0004871; GO:0005525; GO:0007186; GO:0046872 0 0 0 PF00503; O17214 CHOYP_FUMH.2.2 m.55401 sp FUMH_CAEEL 72.845 464 126 0 1 464 38 501 0 714 FUMH_CAEEL reviewed "Probable fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)" fum-1 H14A12.2 Caenorhabditis elegans 501 fumarate metabolic process [GO:0006106]; malate metabolic process [GO:0006108]; protein tetramerization [GO:0051262]; tricarboxylic acid cycle [GO:0006099] GO:0004333; GO:0005739; GO:0005829; GO:0006099; GO:0006106; GO:0006108; GO:0045239; GO:0051262 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. 0 0 PF10415;PF00206; O17320 CHOYP_ACT.1.27 m.418 sp ACT_CRAGI 97.786 271 6 0 12 282 106 376 0 548 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_ACT.19.27 m.53935 sp ACT_CRAGI 84.043 376 60 0 1 376 1 376 0 670 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_ACT.21.27 m.57705 sp ACT_CRAGI 81.176 425 27 2 1 421 1 376 0 697 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_ACT.23.27 m.58454 sp ACT_CRAGI 87.234 376 44 1 1 372 1 376 0 685 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_ACT.24.27 m.63922 sp ACT_CRAGI 81.361 338 59 1 4 337 1 338 0 569 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_ACT.9.27 m.24629 sp ACT_CRAGI 99.315 292 2 0 5 296 85 376 0 603 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_CPIPJ_CPIJ005785.1.1 m.13042 sp ACT_CRAGI 89.583 288 16 1 1 288 1 274 0 540 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_LOC752782.1.1 m.53937 sp ACT_CRAGI 99.202 376 3 0 58 433 1 376 0 783 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17320 CHOYP_NEMVEDRAFT_V1G242065.1.1 m.21817 sp ACT_CRAGI 94.684 301 16 0 1 301 1 301 0 600 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O17583 CHOYP_LOC657912.1.1 m.22433 sp LIN10_CAEEL 66.749 406 114 4 673 1061 580 981 0 558 LIN10_CAEEL reviewed Protein lin-10 (Abnormal cell lineage protein 10) lin-10 C09H6.2 Caenorhabditis elegans 982 asymmetric protein localization [GO:0008105]; nervous system development [GO:0007399]; neuron-neuron synaptic transmission [GO:0007270]; positive regulation of vulval development [GO:0040026]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to early endosome [GO:1902946]; receptor localization to synapse [GO:0097120]; sensory perception of touch [GO:0050975]; transport [GO:0006810] GO:0000138; GO:0005737; GO:0005794; GO:0005886; GO:0006810; GO:0007270; GO:0007399; GO:0008105; GO:0017137; GO:0030054; GO:0030140; GO:0030425; GO:0032580; GO:0040026; GO:0043005; GO:0043025; GO:0045202; GO:0050975; GO:0097120; GO:1902946; GO:1903361 0 0 0 PF00595;PF00640; O18373 CHOYP_HSP7D.3.3 m.41778 sp SPS1_DROME 83.495 309 51 0 1 309 90 398 0 563 SPS1_DROME reviewed "Selenide, water dikinase (EC 2.7.9.3) (Protein patufet) (Selenium donor protein) (Selenophosphate synthase) (dSelD)" SelD PTF1 ptuf CG8553 Drosophila melanogaster (Fruit fly) 398 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; glutamine metabolic process [GO:0006541]; imaginal disc development [GO:0007444]; mitochondrion organization [GO:0007005]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neurogenesis [GO:0022008]; positive regulation of cell proliferation [GO:0008284]; regulation of glucose metabolic process [GO:0010906]; selenocysteine biosynthetic process [GO:0016260] GO:0005524; GO:0006541; GO:0007005; GO:0007049; GO:0007444; GO:0008283; GO:0008284; GO:0010906; GO:0016260; GO:0016301; GO:0022008; GO:2000378 0 0 0 PF00586;PF02769; O18373 CHOYP_NEMVEDRAFT_V1G135670.1.1 m.18690 sp SPS1_DROME 83.172 309 52 0 1 309 90 398 0 558 SPS1_DROME reviewed "Selenide, water dikinase (EC 2.7.9.3) (Protein patufet) (Selenium donor protein) (Selenophosphate synthase) (dSelD)" SelD PTF1 ptuf CG8553 Drosophila melanogaster (Fruit fly) 398 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; glutamine metabolic process [GO:0006541]; imaginal disc development [GO:0007444]; mitochondrion organization [GO:0007005]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neurogenesis [GO:0022008]; positive regulation of cell proliferation [GO:0008284]; regulation of glucose metabolic process [GO:0010906]; selenocysteine biosynthetic process [GO:0016260] GO:0005524; GO:0006541; GO:0007005; GO:0007049; GO:0007444; GO:0008283; GO:0008284; GO:0010906; GO:0016260; GO:0016301; GO:0022008; GO:2000378 0 0 0 PF00586;PF02769; O18373 CHOYP_SELD.1.2 m.8599 sp SPS1_DROME 83.495 309 51 0 1 309 90 398 0 563 SPS1_DROME reviewed "Selenide, water dikinase (EC 2.7.9.3) (Protein patufet) (Selenium donor protein) (Selenophosphate synthase) (dSelD)" SelD PTF1 ptuf CG8553 Drosophila melanogaster (Fruit fly) 398 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; glutamine metabolic process [GO:0006541]; imaginal disc development [GO:0007444]; mitochondrion organization [GO:0007005]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neurogenesis [GO:0022008]; positive regulation of cell proliferation [GO:0008284]; regulation of glucose metabolic process [GO:0010906]; selenocysteine biosynthetic process [GO:0016260] GO:0005524; GO:0006541; GO:0007005; GO:0007049; GO:0007444; GO:0008283; GO:0008284; GO:0010906; GO:0016260; GO:0016301; GO:0022008; GO:2000378 0 0 0 PF00586;PF02769; O18373 CHOYP_SELD.2.2 m.60984 sp SPS1_DROME 83.495 309 51 0 1 309 90 398 0 563 SPS1_DROME reviewed "Selenide, water dikinase (EC 2.7.9.3) (Protein patufet) (Selenium donor protein) (Selenophosphate synthase) (dSelD)" SelD PTF1 ptuf CG8553 Drosophila melanogaster (Fruit fly) 398 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; glutamine metabolic process [GO:0006541]; imaginal disc development [GO:0007444]; mitochondrion organization [GO:0007005]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neurogenesis [GO:0022008]; positive regulation of cell proliferation [GO:0008284]; regulation of glucose metabolic process [GO:0010906]; selenocysteine biosynthetic process [GO:0016260] GO:0005524; GO:0006541; GO:0007005; GO:0007049; GO:0007444; GO:0008283; GO:0008284; GO:0010906; GO:0016260; GO:0016301; GO:0022008; GO:2000378 0 0 0 PF00586;PF02769; O19015 CHOYP_BGAL.2.2 m.41942 sp BGAL_FELCA 51.756 655 274 11 23 661 22 650 0 644 BGAL_FELCA reviewed Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) GLB1 BGAL Felis catus (Cat) (Felis silvestris catus) 669 carbohydrate metabolic process [GO:0005975] GO:0004565; GO:0005764; GO:0005773; GO:0005975 0 0 0 PF13364;PF01301; O35134 CHOYP_RPA1.2.2 m.6583 sp RPA1_MOUSE 48.956 1724 797 18 6 1665 8 1712 0 1543 RPA1_MOUSE reviewed DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) Polr1a Rpa1 Rpo1-4 Mus musculus (Mouse) 1717 chromatin silencing at rDNA [GO:0000183]; transcription initiation from RNA polymerase I promoter [GO:0006361] GO:0000183; GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005730; GO:0005736; GO:0005737; GO:0006361; GO:0008270 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998; O35161 CHOYP_LOC100704608.1.1 m.53781 sp CELR1_MOUSE 37.274 2715 1506 46 256 2881 240 2846 0 1806 CELR1_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 1 Celsr1 Mus musculus (Mouse) 3034 anterior/posterior pattern specification [GO:0009952]; apical protein localization [GO:0045176]; cell-cell signaling [GO:0007267]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; gastrulation with mouth forming second [GO:0001702]; G-protein coupled receptor signaling pathway [GO:0007186]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear morphogenesis [GO:0042472]; lateral sprouting involved in lung morphogenesis [GO:0060490]; locomotory behavior [GO:0007626]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of neurotransmitter secretion [GO:0046928]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; wound healing [GO:0042060] GO:0001702; GO:0001736; GO:0001764; GO:0001843; GO:0001942; GO:0004888; GO:0004930; GO:0005509; GO:0005654; GO:0005886; GO:0005887; GO:0007156; GO:0007165; GO:0007186; GO:0007266; GO:0007267; GO:0007417; GO:0007626; GO:0009952; GO:0016020; GO:0032956; GO:0042060; GO:0042249; GO:0042472; GO:0045176; GO:0046928; GO:0046983; GO:0048105; GO:0060488; GO:0060489; GO:0060490; GO:0090179; GO:0090251 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF02793;PF00053;PF02210; O35218 CHOYP_CPSF2.1.1 m.13908 sp CPSF2_MOUSE 62.563 788 265 7 1 764 1 782 0 1014 CPSF2_MOUSE reviewed Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) Cpsf2 Cpsf100 Mcpsf Mus musculus (Mouse) 782 mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; mRNA cleavage [GO:0006379]; mRNA polyadenylation [GO:0006378] GO:0003723; GO:0005847; GO:0006378; GO:0006379; GO:0006398; GO:0016020 0 0 0 PF10996;PF13299;PF16661;PF07521; O35344 CHOYP_LOC100533341.1.1 m.1846 sp IMA4_MOUSE 75.342 511 121 3 10 515 11 521 0 790 IMA4_MOUSE reviewed Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) Kpna3 Qip2 Mus musculus (Mouse) 521 NLS-bearing protein import into nucleus [GO:0006607] GO:0005643; GO:0005654; GO:0005829; GO:0006607; GO:0008022; GO:0008139; GO:0008565 0 0 0 PF00514;PF16186;PF01749; O35345 CHOYP_BRAFLDRAFT_279360.1.1 m.11115 sp IMA7_MOUSE 75.189 528 125 5 15 540 13 536 0 774 IMA7_MOUSE reviewed Importin subunit alpha-7 (Importin alpha-S2) (Karyopherin subunit alpha-6) Kpna6 Kpna5 Mus musculus (Mouse) 536 maternal process involved in female pregnancy [GO:0060135]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein import into nucleus [GO:0006606] GO:0005643; GO:0005654; GO:0005829; GO:0006606; GO:0006607; GO:0008139; GO:0008565; GO:0016020; GO:0045944; GO:0060135 0 0 0 PF00514;PF16186;PF01749; O35379 CHOYP_MRP1.7.10 m.36483 sp MRP1_MOUSE 50.682 1539 691 18 1 1524 43 1528 0 1502 MRP1_MOUSE reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Abcc1a Abcc1b Mdrap Mrp Mus musculus (Mouse) 1528 0 GO:0005524; GO:0005886; GO:0005887; GO:0016020; GO:0016323; GO:0016887; GO:0042626; GO:0070062 0 0 0 PF00664;PF00005; O35379 CHOYP_MRP1.9.10 m.62903 sp MRP1_MOUSE 53.191 1316 551 15 1 1303 227 1490 0 1373 MRP1_MOUSE reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Abcc1a Abcc1b Mdrap Mrp Mus musculus (Mouse) 1528 0 GO:0005524; GO:0005886; GO:0005887; GO:0016020; GO:0016323; GO:0016887; GO:0042626; GO:0070062 0 0 0 PF00664;PF00005; O35594 CHOYP_LOC100366734.1.1 m.47271 sp IFT81_MOUSE 52.838 687 308 3 1 682 1 676 0 727 IFT81_MOUSE reviewed Intraflagellar transport protein 81 homolog (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1) Ift81 Cdv-1 Cdv1 Mus musculus (Mouse) 676 cell differentiation [GO:0030154]; cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005813; GO:0005929; GO:0007275; GO:0007283; GO:0015631; GO:0030154; GO:0030992; GO:0035735; GO:0036064; GO:0042073; GO:0042384; GO:0072372; GO:0097225; GO:0097228 0 0 0 0 O35704 CHOYP_CLCA1.1.1 m.63607 sp SPTC1_MOUSE 58.562 473 190 3 6 476 4 472 0 581 SPTC1_MOUSE reviewed Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) Sptlc1 Lcb1 Mus musculus (Mouse) 473 ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] GO:0006686; GO:0016021; GO:0016746; GO:0017059; GO:0030148; GO:0030170; GO:0035339; GO:0046511; GO:0046512; GO:0046513; GO:1904504 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00155; O35704 CHOYP_SPTC1.1.1 m.44477 sp SPTC1_MOUSE 58.562 473 190 3 32 502 4 472 0 580 SPTC1_MOUSE reviewed Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1) Sptlc1 Lcb1 Mus musculus (Mouse) 473 ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] GO:0006686; GO:0016021; GO:0016746; GO:0017059; GO:0030148; GO:0030170; GO:0035339; GO:0046511; GO:0046512; GO:0046513; GO:1904504 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00155; O35920 CHOYP_LOC100747565.2.2 m.56954 sp CAN9_RAT 43.106 689 357 15 76 751 18 684 0 553 CAN9_RAT reviewed Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) Capn9 Ncl4 Rattus norvegicus (Rat) 690 digestion [GO:0007586] GO:0004198; GO:0005509; GO:0005737; GO:0007586 0 0 0 PF01067;PF13833;PF00648; O35954 CHOYP_PITM2.1.2 m.549 sp PITM1_MOUSE 45.295 1254 579 28 1 1209 1 1192 0 1017 PITM1_MOUSE reviewed "Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog 1) (RdgB1) (Mpt-1) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)" Pitpnm1 Dres9 Mpt1 Nir2 Pitpnm Mus musculus (Mouse) 1243 protein transport [GO:0015031] GO:0005543; GO:0005737; GO:0005789; GO:0005811; GO:0015031; GO:0030496; GO:0032154; GO:0032580; GO:0046872 0 0 0 PF02862;PF02121; O42249 CHOYP_GBLP.3.7 m.20931 sp GBLP_ORENI 85.804 317 45 0 24 340 1 317 0 584 GBLP_ORENI reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 317 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:2000114; GO:2000543 0 0 0 PF00400; O42249 CHOYP_GBLP.7.7 m.66711 sp GBLP_ORENI 85.804 317 45 0 1 317 1 317 0 584 GBLP_ORENI reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 317 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:2000114; GO:2000543 0 0 0 PF00400; O42249 CHOYP_TBB.7.7 m.66812 sp GBLP_ORENI 86.379 301 41 0 1 301 1 301 0 556 GBLP_ORENI reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 317 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:2000114; GO:2000543 0 0 0 PF00400; O42611 CHOYP_HIRA.1.1 m.19212 sp HIRA_TAKRU 45.563 1093 473 28 1 1039 1 1025 0 883 HIRA_TAKRU reviewed Protein HIRA (TUP1-like enhancer of split protein 1) hira tuple1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 1025 "chromatin modification [GO:0016568]; covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0016568; GO:0016569 0 0 0 PF07569;PF09453;PF00400; O43143 CHOYP_DHX15.2.2 m.62441 sp DHX15_HUMAN 85.441 680 98 1 55 733 115 794 0 1241 DHX15_HUMAN reviewed Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 (EC 3.6.4.13) (ATP-dependent RNA helicase #46) (DEAH box protein 15) DHX15 DBP1 DDX15 Homo sapiens (Human) 795 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA splicing [GO:0008380]" GO:0000398; GO:0003724; GO:0003725; GO:0004004; GO:0005524; GO:0005634; GO:0005689; GO:0005730; GO:0005737; GO:0006397; GO:0008380; GO:0009636; GO:0043279; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF07717; O43156 CHOYP_BRAFLDRAFT_231367.1.1 m.32006 sp TTI1_HUMAN 36.645 1097 637 14 38 1096 10 1086 0 654 TTI1_HUMAN reviewed TELO2-interacting protein 1 homolog (Protein SMG10) TTI1 KIAA0406 SMG10 Homo sapiens (Human) 1089 regulation of TOR signaling [GO:0032006] GO:0005737; GO:0031931; GO:0031932; GO:0032006 0 0 0 0 O43172 CHOYP_PRPF4.1.1 m.62194 sp PRP4_HUMAN 62.941 510 183 5 8 516 18 522 0 666 PRP4_HUMAN reviewed U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4) PRPF4 PRP4 Homo sapiens (Human) 522 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0005634; GO:0005654; GO:0005681; GO:0006396; GO:0008380; GO:0015030; GO:0016607; GO:0017070; GO:0030621; GO:0046540; GO:0071001; GO:0097525 0 0 0 PF08799;PF00400; O43432 CHOYP_BRAFLDRAFT_277494.2.3 m.57496 sp IF4G3_HUMAN 44.551 936 429 22 18 917 704 1585 0 712 IF4G3_HUMAN reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) EIF4G3 Homo sapiens (Human) 1585 regulation of translational initiation [GO:0006446]; viral process [GO:0016032] GO:0000339; GO:0003743; GO:0005829; GO:0006446; GO:0008135; GO:0016032; GO:0016281; GO:0044822 0 0 0 PF02847;PF02854;PF02020; O43451 CHOYP_MGA.1.2 m.13126 sp MGA_HUMAN 42.982 912 473 20 63 957 75 956 0 704 MGA_HUMAN reviewed "Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]" MGAM MGA MGAML Homo sapiens (Human) 1857 polysaccharide digestion [GO:0044245]; starch catabolic process [GO:0005983] GO:0003824; GO:0004339; GO:0004558; GO:0005886; GO:0005983; GO:0016021; GO:0016160; GO:0016324; GO:0030246; GO:0032450; GO:0044245; GO:0070062 0 0 cd00111; PF01055;PF16863;PF00088; O43451 CHOYP_MGAM.1.1 m.41738 sp MGA_HUMAN 41.621 1814 890 49 35 1782 76 1786 0 1314 MGA_HUMAN reviewed "Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]" MGAM MGA MGAML Homo sapiens (Human) 1857 polysaccharide digestion [GO:0044245]; starch catabolic process [GO:0005983] GO:0003824; GO:0004339; GO:0004558; GO:0005886; GO:0005983; GO:0016021; GO:0016160; GO:0016324; GO:0030246; GO:0032450; GO:0044245; GO:0070062 0 0 cd00111; PF01055;PF16863;PF00088; O43909 CHOYP_LOC100121031.2.2 m.52479 sp EXTL3_HUMAN 49.292 848 420 6 6 849 78 919 0 858 EXTL3_HUMAN reviewed Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3) EXTL3 EXTL1L EXTR1 KIAA0519 Homo sapiens (Human) 919 glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; IRE1-mediated unfolded protein response [GO:0036498]; positive regulation of cell growth [GO:0030307] GO:0001888; GO:0004872; GO:0005783; GO:0005789; GO:0006024; GO:0015012; GO:0016021; GO:0030307; GO:0036498; GO:0046872 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. 0 0 PF03016;PF09258; O43933 CHOYP_LOC592476.1.1 m.869 sp PEX1_HUMAN 37.993 1116 587 21 6 1088 17 1060 0 672 PEX1_HUMAN reviewed Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1) PEX1 Homo sapiens (Human) 1283 microtubule-based peroxisome localization [GO:0060152]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein targeting to peroxisome [GO:0006625] GO:0005524; GO:0005737; GO:0005777; GO:0005778; GO:0005829; GO:0006625; GO:0007031; GO:0008022; GO:0016558; GO:0032403; GO:0042623; GO:0043231; GO:0060152; GO:0070062 0 0 0 PF00004;PF09262;PF09263; O45947 CHOYP_LOC100902628.1.1 m.1200 sp GLT10_CAEEL 53.374 652 267 14 5 628 39 681 0 653 GLT10_CAEEL reviewed Putative polypeptide N-acetylgalactosaminyltransferase 10 (pp-GaNTase 10) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) gly-10 Y45F10D.3 Caenorhabditis elegans 684 protein glycosylation [GO:0006486] GO:0000139; GO:0004653; GO:0006486; GO:0016021; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; O46036 CHOYP_PHUM_PHUM549040.1.1 m.10284 sp CTBP_DROME 80.716 363 63 3 1 363 1 356 0 614 CTBP_DROME reviewed C-terminal-binding protein (CtBP protein) (dCtBP) CtBP CG7583 Drosophila melanogaster (Fruit fly) 476 "ATP-dependent chromatin remodeling [GO:0043044]; chaeta development [GO:0022416]; embryonic development via the syncytial blastoderm [GO:0001700]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of JAK-STAT cascade [GO:0046427]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of Wnt signaling pathway [GO:0030111]; sensory organ precursor cell fate determination [GO:0016360]; sensory perception of pain [GO:0019233]; transcription, DNA-templated [GO:0006351]; wing disc development [GO:0035220]; Wnt signaling pathway [GO:0016055]" GO:0000122; GO:0001700; GO:0003713; GO:0003714; GO:0005634; GO:0006351; GO:0006355; GO:0006357; GO:0008134; GO:0016055; GO:0016360; GO:0016616; GO:0019233; GO:0022416; GO:0030111; GO:0031010; GO:0035220; GO:0042802; GO:0042803; GO:0043044; GO:0045892; GO:0046427; GO:0051287; GO:0070491 0 0 0 PF00389;PF02826; O46037 CHOYP_LOC100371677.1.1 m.122 sp VINC_DROME 48.316 1039 453 14 1 1035 1 959 0 893 VINC_DROME reviewed Vinculin Vinc CG3299 Drosophila melanogaster (Fruit fly) 961 cell adhesion [GO:0007155]; cytoskeletal anchoring at plasma membrane [GO:0007016]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909] GO:0003779; GO:0005198; GO:0005737; GO:0005886; GO:0005925; GO:0006909; GO:0007016; GO:0007155; GO:0015629; GO:0048812 0 0 0 PF01044; O46037 CHOYP_LOC100744506.1.1 m.44043 sp VINC_DROME 55.465 979 410 8 1 973 1 959 0 1045 VINC_DROME reviewed Vinculin Vinc CG3299 Drosophila melanogaster (Fruit fly) 961 cell adhesion [GO:0007155]; cytoskeletal anchoring at plasma membrane [GO:0007016]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909] GO:0003779; GO:0005198; GO:0005737; GO:0005886; GO:0005925; GO:0006909; GO:0007016; GO:0007155; GO:0015629; GO:0048812 0 0 0 PF01044; O46385 CHOYP_LOC578781.4.5 m.19607 sp SVIL_BOVIN 41.083 1127 586 24 1051 2135 1104 2194 0 866 SVIL_BOVIN reviewed Supervillin (Archvillin) (p205/p250) SVIL Bos taurus (Bovine) 2194 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467] GO:0002102; GO:0005737; GO:0005886; GO:0007010; GO:0030054; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0071437 0 0 0 PF00626;PF02209; O46629 CHOYP_LOC100703423.1.1 m.941 sp ECHB_BOVIN 69.099 466 129 4 13 467 14 475 0 651 ECHB_BOVIN reviewed "Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]" HADHB Bos taurus (Bovine) 475 fatty acid beta-oxidation [GO:0006635] GO:0003988; GO:0005741; GO:0005743; GO:0005783; GO:0006635; GO:0016509; GO:0042645; GO:0044822; GO:0070062 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF02803;PF00108; O54774 CHOYP_BRAFLDRAFT_276908.1.1 m.28793 sp AP3D1_MOUSE 71.879 825 219 6 1 819 1 818 0 1212 AP3D1_MOUSE reviewed AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) (mBLVR1) Ap3d1 Ap3d Mus musculus (Mouse) 1199 "anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; antigen processing and presentation [GO:0019882]; antigen processing and presentation, exogenous lipid antigen via MHC class Ib [GO:0048007]; endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; positive regulation of NK T cell differentiation [GO:0051138]; protein localization to membrane [GO:0072657]; protein localization to organelle [GO:0033365]; regulation of sequestering of zinc ion [GO:0061088]; synaptic vesicle membrane organization [GO:0048499]; vesicle-mediated transport [GO:0016192]; zinc II ion transport [GO:0006829]" GO:0000139; GO:0005654; GO:0005765; GO:0005802; GO:0006829; GO:0006886; GO:0008089; GO:0010008; GO:0016020; GO:0016192; GO:0019882; GO:0030123; GO:0030424; GO:0033365; GO:0035646; GO:0043195; GO:0048007; GO:0048490; GO:0048499; GO:0051138; GO:0061088; GO:0072657; GO:1904115 0 0 0 PF01602;PF06375; O54829 CHOYP_LOC655987.3.3 m.50202 sp RGS7_MOUSE 59.193 446 170 5 34 475 16 453 0 553 RGS7_MOUSE reviewed Regulator of G-protein signaling 7 (RGS7) Rgs7 Mus musculus (Mouse) 469 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0004871; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005834; GO:0005886; GO:0007186; GO:0008277; GO:0009968; GO:0031681; GO:0035556; GO:0043547; GO:0044292 0 0 cd00068; PF00610;PF00631;PF00615; O54852 CHOYP_LOC100371738.2.3 m.31321 sp KCNH7_RAT 59.503 805 240 14 2 732 74 866 0 920 KCNH7_RAT reviewed Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (Voltage-gated potassium channel subunit Kv11.3) Kcnh7 Erg3 Rattus norvegicus (Rat) 1195 circadian rhythm [GO:0007623]; potassium ion transport [GO:0006813]; protein heterooligomerization [GO:0051291]; regulation of membrane potential [GO:0042391] GO:0005242; GO:0005249; GO:0005267; GO:0005887; GO:0006813; GO:0007623; GO:0042391; GO:0051291 0 0 0 PF00027;PF00520;PF13426; O54874 CHOYP_CDC42BPA.1.1 m.50442 sp MRCKA_RAT 41.674 1135 565 19 3 1111 601 1664 0 839 MRCKA_RAT reviewed Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Cdc42bpa Pk428 Rattus norvegicus (Rat) 1732 actin cytoskeleton reorganization [GO:0031532]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0000287; GO:0004674; GO:0005524; GO:0005737; GO:0005911; GO:0006468; GO:0007010; GO:0016477; GO:0031032; GO:0031252; GO:0031532; GO:0035556; GO:0042641; GO:0042802; GO:0051056 0 0 0 PF00130;PF00780;PF08826;PF15796;PF00069;PF00433; O54874 CHOYP_GEK.1.1 m.4939 sp MRCKA_RAT 47.442 1720 783 25 2 1677 1 1643 0 1571 MRCKA_RAT reviewed Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Cdc42bpa Pk428 Rattus norvegicus (Rat) 1732 actin cytoskeleton reorganization [GO:0031532]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0000287; GO:0004674; GO:0005524; GO:0005737; GO:0005911; GO:0006468; GO:0007010; GO:0016477; GO:0031032; GO:0031252; GO:0031532; GO:0035556; GO:0042641; GO:0042802; GO:0051056 0 0 0 PF00130;PF00780;PF08826;PF15796;PF00069;PF00433; O54902 CHOYP_LOC100304514.1.1 m.52847 sp NRAM2_RAT 65.844 486 162 3 1 484 56 539 0 626 NRAM2_RAT reviewed Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) Slc11a2 Dct1 Dmt1 Nramp2 Rattus norvegicus (Rat) 568 cellular copper ion homeostasis [GO:0006878]; cellular response to hypoxia [GO:0071456]; cellular response to iron ion [GO:0071281]; cellular response to tumor necrosis factor [GO:0071356]; copper ion import into cell [GO:1902861]; ferrous iron transport [GO:0015684]; iron ion homeostasis [GO:0055072]; response to cadmium ion [GO:0046686]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to lead ion [GO:0010288]; response to manganese ion [GO:0010042]; transition metal ion transport [GO:0000041] GO:0000041; GO:0001666; GO:0005375; GO:0005381; GO:0005384; GO:0005506; GO:0005507; GO:0005737; GO:0005741; GO:0005765; GO:0005769; GO:0005887; GO:0006878; GO:0008270; GO:0010039; GO:0010042; GO:0010288; GO:0015086; GO:0015087; GO:0015093; GO:0015094; GO:0015099; GO:0015639; GO:0015684; GO:0016021; GO:0016151; GO:0030145; GO:0031902; GO:0045177; GO:0046686; GO:0046870; GO:0050897; GO:0055072; GO:0071281; GO:0071356; GO:0071456; GO:1902861 0 0 0 PF01566; O54922 CHOYP_LOC574569.1.1 m.61069 sp EXOC7_RAT 42.083 701 351 8 4 703 7 653 0 544 EXOC7_RAT reviewed Exocyst complex component 7 (Exocyst complex component Exo70) (rExo70) Exoc7 Exo70 Rattus norvegicus (Rat) 653 exocytosis [GO:0006887]; protein transport [GO:0015031] GO:0000145; GO:0005829; GO:0005886; GO:0006887; GO:0015031 0 0 0 PF03081; O55096 CHOYP_LOC582874.1.1 m.5135 sp DPP3_RAT 58.503 735 289 7 30 755 1 728 0 875 DPP3_RAT reviewed Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B) Dpp3 Rattus norvegicus (Rat) 738 proteolysis [GO:0006508] GO:0005654; GO:0005737; GO:0005886; GO:0006508; GO:0008237; GO:0008239; GO:0008270; GO:0070062 0 0 0 0 O55173 CHOYP_LOC100533218.1.1 m.56993 sp PDPK1_RAT 59.252 481 149 5 13 455 79 550 0 573 PDPK1_RAT reviewed 3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Pdpk1 Pdk1 Rattus norvegicus (Rat) 559 "activation of protein kinase B activity [GO:0032148]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; epidermal growth factor receptor signaling pathway [GO:0007173]; extrinsic apoptotic signaling pathway [GO:0097191]; focal adhesion assembly [GO:0048041]; hyperosmotic response [GO:0006972]; intracellular signal transduction [GO:0035556]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; platelet activation [GO:0030168]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of endothelial cell migration [GO:0010594]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mast cell degranulation [GO:0043304]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; type B pancreatic cell development [GO:0003323]" GO:0003323; GO:0004676; GO:0005158; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0005925; GO:0006351; GO:0006355; GO:0006469; GO:0006972; GO:0007173; GO:0010518; GO:0010594; GO:0010667; GO:0016004; GO:0016023; GO:0016477; GO:0018105; GO:0018107; GO:0019722; GO:0019901; GO:0030168; GO:0030512; GO:0032148; GO:0032869; GO:0034122; GO:0035556; GO:0042995; GO:0043122; GO:0043204; GO:0043304; GO:0043524; GO:0048041; GO:0051281; GO:0071364; GO:0090004; GO:0097191; GO:1990416 0 0 0 PF00069; O55236 CHOYP_MCE1.1.1 m.44372 sp MCE1_MOUSE 55.405 592 244 7 13 590 7 592 0 670 MCE1_MOUSE reviewed mRNA-capping enzyme (HCE) (MCE1) [Includes: Polynucleotide 5'-triphosphatase (TPase) (mRNA 5'-triphosphatase) (EC 3.1.3.33); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)] Rngtt Cap1a Mus musculus (Mouse) 597 7-methylguanosine mRNA capping [GO:0006370]; RNA processing [GO:0006396] GO:0004484; GO:0004651; GO:0004725; GO:0005525; GO:0005634; GO:0006370; GO:0006396; GO:0008138; GO:0008192; GO:0050355 0 0 0 PF00782;PF03919;PF01331; O57478 CHOYP_LOC100692139.1.1 m.27787 sp HEMH_XENLA 70.33 364 107 1 40 402 46 409 0 543 HEMH_XENLA reviewed "Ferrochelatase, mitochondrial (EC 4.99.1.1) (Heme synthase) (Protoheme ferro-lyase)" fech Xenopus laevis (African clawed frog) 411 heme biosynthetic process [GO:0006783] GO:0004325; GO:0005743; GO:0006783; GO:0046872; GO:0051537 PATHWAY: Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. 0 cd00419;cd03411; PF00762; O57579 CHOYP_APN.1.3 m.316 sp AMPN_CHICK 43.126 902 474 14 123 1000 74 960 0 746 AMPN_CHICK reviewed Aminopeptidase Ey (EC 3.4.11.20) ANPEP APDE Gallus gallus (Chicken) 967 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; O57683 CHOYP_SF3B1.1.3 m.24001 sp SF3B1_XENLA 77.802 1356 231 16 1265 2602 4 1307 0 2133 SF3B1_XENLA reviewed Splicing factor 3B subunit 1 (146 kDa nuclear protein) (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) sf3b1 Xenopus laevis (African clawed frog) 1307 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0008380 0 0 0 PF08920; O60229 CHOYP_KALRN.1.2 m.891 sp KALRN_HUMAN 43.942 2988 1437 50 1 2872 102 2967 0 2434 KALRN_HUMAN reviewed Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) KALRN DUET DUO HAPIP TRAD Homo sapiens (Human) 2985 ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; protein phosphorylation [GO:0006468]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] GO:0004674; GO:0005085; GO:0005089; GO:0005096; GO:0005524; GO:0005829; GO:0006468; GO:0007165; GO:0007399; GO:0015629; GO:0016192; GO:0035023; GO:0035556; GO:0043065; GO:0046872; GO:0048013; GO:0051056; GO:0070062 0 0 0 PF00650;PF00041;PF07679;PF00169;PF00069;PF00621;PF00435; O60231 CHOYP_LOC100375367.1.1 m.10761 sp DHX16_HUMAN 64.423 1040 346 9 5 1026 7 1040 0 1387 DHX16_HUMAN reviewed Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.4.13) (ATP-dependent RNA helicase #3) (DEAH-box protein 16) DHX16 DBP2 DDX16 KIAA0577 Homo sapiens (Human) 1041 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]" GO:0000398; GO:0003724; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0008380; GO:0016887; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF07717; O60244 CHOYP_PHUM_PHUM128490.1.1 m.8150 sp MED14_HUMAN 43.152 1453 737 31 45 1463 51 1448 0 1064 MED14_HUMAN reviewed Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170 Homo sapiens (Human) 1454 "androgen receptor signaling pathway [GO:0030521]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; stem cell population maintenance [GO:0019827]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001104; GO:0003712; GO:0003713; GO:0004872; GO:0005634; GO:0005654; GO:0006357; GO:0006367; GO:0016020; GO:0016592; GO:0019827; GO:0030374; GO:0030518; GO:0030521; GO:0042809; GO:0045893; GO:0045944; GO:0070847 0 0 0 PF08638; O60264 CHOYP_SMARCA5.1.1 m.31708 sp SMCA5_HUMAN 77.232 997 212 8 62 1056 68 1051 0 1546 SMCA5_HUMAN reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H) SMARCA5 SNF2H WCRF135 Homo sapiens (Human) 1052 "ATP-dependent chromatin remodeling [GO:0043044]; CENP-A containing nucleosome assembly [GO:0034080]; chromatin remodeling [GO:0006338]; chromatin silencing at rDNA [GO:0000183]; covalent chromatin modification [GO:0016569]; DNA-templated transcription, initiation [GO:0006352]; double-strand break repair [GO:0006302]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]" GO:0000183; GO:0000793; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005677; GO:0005730; GO:0006302; GO:0006334; GO:0006338; GO:0006352; GO:0006357; GO:0016569; GO:0016584; GO:0016589; GO:0016887; GO:0031213; GO:0034080; GO:0043044; GO:0045815; GO:0045893 0 0 0 PF13892;PF09110;PF00271;PF09111;PF00176; O60271 CHOYP_JIP4.2.4 m.31575 sp JIP4_HUMAN 47.055 1477 575 37 15 1461 17 1316 0 1162 JIP4_HUMAN reviewed C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 Homo sapiens (Human) 1321 "activation of JUN kinase activity [GO:0007257]; negative regulation of protein homodimerization activity [GO:0090074]; positive regulation of cell migration [GO:0030335]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]" GO:0001669; GO:0005078; GO:0005737; GO:0005815; GO:0005829; GO:0007257; GO:0007283; GO:0008432; GO:0016021; GO:0019894; GO:0030159; GO:0030335; GO:0042147; GO:0045666; GO:0048471; GO:0051146; GO:0051149; GO:0051260; GO:0070062; GO:0090074 0 0 0 PF16471;PF09744; O60271 CHOYP_JIP4.3.4 m.39288 sp JIP4_HUMAN 45.941 1515 574 37 15 1499 17 1316 0 1153 JIP4_HUMAN reviewed C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 Homo sapiens (Human) 1321 "activation of JUN kinase activity [GO:0007257]; negative regulation of protein homodimerization activity [GO:0090074]; positive regulation of cell migration [GO:0030335]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]" GO:0001669; GO:0005078; GO:0005737; GO:0005815; GO:0005829; GO:0007257; GO:0007283; GO:0008432; GO:0016021; GO:0019894; GO:0030159; GO:0030335; GO:0042147; GO:0045666; GO:0048471; GO:0051146; GO:0051149; GO:0051260; GO:0070062; GO:0090074 0 0 0 PF16471;PF09744; O60271 CHOYP_JIP4.4.4 m.65238 sp JIP4_HUMAN 46.586 1494 574 37 15 1478 17 1316 0 1160 JIP4_HUMAN reviewed C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 Homo sapiens (Human) 1321 "activation of JUN kinase activity [GO:0007257]; negative regulation of protein homodimerization activity [GO:0090074]; positive regulation of cell migration [GO:0030335]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]" GO:0001669; GO:0005078; GO:0005737; GO:0005815; GO:0005829; GO:0007257; GO:0007283; GO:0008432; GO:0016021; GO:0019894; GO:0030159; GO:0030335; GO:0042147; GO:0045666; GO:0048471; GO:0051146; GO:0051149; GO:0051260; GO:0070062; GO:0090074 0 0 0 PF16471;PF09744; O60303 CHOYP_KIAA0556.1.1 m.9772 sp K0556_HUMAN 54.459 740 325 7 748 1483 884 1615 0 822 K0556_HUMAN reviewed Protein KIAA0556 KIAA0556 Homo sapiens (Human) 1618 0 GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0042995 0 0 0 PF14652; O60306 CHOYP_AQR.1.1 m.9127 sp AQR_HUMAN 66.501 1409 450 9 1 1399 1 1397 0 1943 AQR_HUMAN reviewed Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160) AQR KIAA0560 Homo sapiens (Human) 1485 "mRNA splicing, via spliceosome [GO:0000398]; transcription-coupled nucleotide-excision repair [GO:0006283]" GO:0000398; GO:0005654; GO:0006283; GO:0016020; GO:0044822; GO:0071013 0 0 0 PF16399; O60308 CHOYP_LOC100369449.1.1 m.16325 sp CE104_HUMAN 46.328 926 413 17 1 876 1 892 0 762 CE104_HUMAN reviewed Centrosomal protein of 104 kDa (Cep104) CEP104 KIAA0562 Homo sapiens (Human) 925 0 GO:0000922; GO:0005814; GO:0005929 0 0 0 0 O60318 CHOYP_MCM3AP.1.1 m.33457 sp GANP_HUMAN 30.609 1872 1065 59 161 1914 37 1792 0 653 GANP_HUMAN reviewed Germinal-center associated nuclear protein (GANP) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase) MCM3AP GANP KIAA0572 MAP80 Homo sapiens (Human) 1980 DNA replication [GO:0006260]; immune system process [GO:0002376]; mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606] GO:0000166; GO:0002376; GO:0003677; GO:0005634; GO:0005643; GO:0005654; GO:0005737; GO:0005829; GO:0006260; GO:0006606; GO:0016746; GO:0031965; GO:0051028 0 0 0 PF16766;PF16769;PF16768;PF03399; O60341 CHOYP_KDM1A.1.1 m.60229 sp KDM1A_HUMAN 69.419 775 195 5 16 784 106 844 0 1087 KDM1A_HUMAN reviewed Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) KDM1A AOF2 KDM1 KIAA0601 LSD1 Homo sapiens (Human) 852 "blood coagulation [GO:0007596]; cell proliferation [GO:0008283]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; granulocyte differentiation [GO:0030851]; histone H3-K4 demethylation [GO:0034720]; histone H3-K9 demethylation [GO:0033169]; in utero embryonic development [GO:0001701]; muscle cell development [GO:0055001]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of histone H3-K4 methylation [GO:0051572]; negative regulation of histone H3-K9 methylation [GO:0051573]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of protein binding [GO:0032091]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pituitary gland development [GO:0021983]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of histone ubiquitination [GO:0033184]; positive regulation of hormone biosynthetic process [GO:0046886]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein demethylation [GO:0006482]; regulation of cellular protein localization [GO:1903827]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of primitive erythrocyte differentiation [GO:0010725]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000784; GO:0000790; GO:0001701; GO:0002039; GO:0003682; GO:0003700; GO:0004407; GO:0005634; GO:0005654; GO:0005667; GO:0006351; GO:0006357; GO:0006482; GO:0007596; GO:0008134; GO:0008283; GO:0010569; GO:0010725; GO:0016491; GO:0019899; GO:0021983; GO:0030374; GO:0030851; GO:0032091; GO:0032451; GO:0032452; GO:0032453; GO:0032454; GO:0033169; GO:0033184; GO:0034644; GO:0034648; GO:0034720; GO:0042162; GO:0043234; GO:0043392; GO:0043426; GO:0043433; GO:0043518; GO:0044212; GO:0045648; GO:0045654; GO:0045892; GO:0045944; GO:0046886; GO:0050660; GO:0050681; GO:0051091; GO:0051572; GO:0051573; GO:0055001; GO:0061752; GO:0071480; GO:1902166; GO:1903827; GO:1990391; GO:2000179; GO:2000648 0 0 0 PF01593;PF04433; O60343 CHOYP_TBCD1.1.1 m.14806 sp TBCD4_HUMAN 35.785 1305 655 33 39 1199 16 1281 0 686 TBCD4_HUMAN reviewed TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) TBC1D4 AS160 KIAA0603 Homo sapiens (Human) 1298 activation of GTPase activity [GO:0090630]; cellular response to insulin stimulus [GO:0032869]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; negative regulation of vesicle fusion [GO:0031339]; regulation of vesicle fusion [GO:0031338]; vesicle-mediated transport [GO:0016192] GO:0005096; GO:0005622; GO:0005737; GO:0006886; GO:0012505; GO:0016192; GO:0017137; GO:0030659; GO:0031338; GO:0031339; GO:0032869; GO:0061024; GO:0070062; GO:0090630 0 0 0 PF11830;PF00640;PF00566; O60343 CHOYP_TBCD4.1.1 m.15182 sp TBCD4_HUMAN 35.714 1302 681 31 39 1220 16 1281 0 689 TBCD4_HUMAN reviewed TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) TBC1D4 AS160 KIAA0603 Homo sapiens (Human) 1298 activation of GTPase activity [GO:0090630]; cellular response to insulin stimulus [GO:0032869]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; negative regulation of vesicle fusion [GO:0031339]; regulation of vesicle fusion [GO:0031338]; vesicle-mediated transport [GO:0016192] GO:0005096; GO:0005622; GO:0005737; GO:0006886; GO:0012505; GO:0016192; GO:0017137; GO:0030659; GO:0031338; GO:0031339; GO:0032869; GO:0061024; GO:0070062; GO:0090630 0 0 0 PF11830;PF00640;PF00566; O60344 CHOYP_PHUM_PHUM135440.1.1 m.40573 sp ECE2_HUMAN 49.782 687 328 7 132 812 208 883 0 717 ECE2_HUMAN reviewed Endothelin-converting enzyme 2 (ECE-2) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)] ECE2 KIAA0604 UNQ403/PRO740 Homo sapiens (Human) 883 brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; cell-cell signaling [GO:0007267]; heart development [GO:0007507]; peptide hormone processing [GO:0016486] GO:0000139; GO:0004222; GO:0007267; GO:0007420; GO:0007507; GO:0008168; GO:0010002; GO:0016021; GO:0016486; GO:0030659; GO:0046872 0 0 cd08662; PF01431;PF05649; O60347 CHOYP_LOC100551549.1.1 m.34080 sp TBC12_HUMAN 54.234 496 198 6 318 787 265 757 0 556 TBC12_HUMAN reviewed TBC1 domain family member 12 TBC1D12 KIAA0608 Homo sapiens (Human) 775 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of autophagosome assembly [GO:2000785]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005776; GO:0006886; GO:0017137; GO:0031338; GO:0055037; GO:0090630; GO:2000785 0 0 0 PF00566; O60494 CHOYP_LOC591417.2.2 m.32373 sp CUBN_HUMAN 40.949 3646 2064 52 133 3737 26 3623 0 2813 CUBN_HUMAN reviewed Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) 3623 cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; tissue homeostasis [GO:0001894]; vitamin D metabolic process [GO:0042359] GO:0001894; GO:0004872; GO:0005215; GO:0005509; GO:0005765; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0005905; GO:0006898; GO:0008203; GO:0009235; GO:0010008; GO:0015031; GO:0015889; GO:0016020; GO:0016324; GO:0030139; GO:0031232; GO:0031419; GO:0031526; GO:0042157; GO:0042359; GO:0042803; GO:0042953; GO:0043202; GO:0070062 0 0 0 PF00431;PF00008;PF12947;PF07645; O60502 CHOYP_LOC100645450.1.1 m.39898 sp OGA_HUMAN 42.188 896 437 14 14 865 58 916 0 701 OGA_HUMAN reviewed Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (EC 3.2.1.-) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) MGEA5 HEXC KIAA0679 MEA5 Homo sapiens (Human) 916 glycoprotein catabolic process [GO:0006516]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517] GO:0004415; GO:0005634; GO:0005829; GO:0006044; GO:0006516; GO:0006517; GO:0016020; GO:0016231 0 0 0 PF07555; O60551 CHOYP_NMT2.1.2 m.10421 sp NMT2_HUMAN 69.359 421 125 3 115 534 81 498 0 621 NMT2_HUMAN reviewed Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Peptide N-myristoyltransferase 2) (Type II N-myristoyltransferase) NMT2 Homo sapiens (Human) 498 intracellular transport of virus [GO:0075733]; N-terminal peptidyl-glycine N-myristoylation [GO:0018008]; regulation of rhodopsin mediated signaling pathway [GO:0022400] GO:0004379; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0018008; GO:0019898; GO:0022400; GO:0075733 0 0 0 PF01233;PF02799; O60678 CHOYP_ANM3.1.1 m.376 sp ANM3_HUMAN 50.46 543 234 8 12 547 14 528 0 529 ANM3_HUMAN reviewed Protein arginine N-methyltransferase 3 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3) PRMT3 HRMT1L3 Homo sapiens (Human) 531 "negative regulation of protein ubiquitination [GO:0031397]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005737; GO:0005829; GO:0005840; GO:0006355; GO:0008168; GO:0008469; GO:0016274; GO:0031397; GO:0035242; GO:0046872 0 0 0 0 O60841 CHOYP_LOC662115.1.2 m.11002 sp IF2P_HUMAN 72.15 614 171 0 572 1185 607 1220 0 981 IF2P_HUMAN reviewed Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) 1220 regulation of translational initiation [GO:0006446] GO:0003743; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006446; GO:0044822; GO:0046872 0 0 0 PF03144;PF11987; O60841 CHOYP_LOC662115.2.2 m.15477 sp IF2P_HUMAN 60.778 900 305 5 371 1240 339 1220 0 1018 IF2P_HUMAN reviewed Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) EIF5B IF2 KIAA0741 Homo sapiens (Human) 1220 regulation of translational initiation [GO:0006446] GO:0003743; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0006446; GO:0044822; GO:0046872 0 0 0 PF03144;PF11987; O61307 CHOYP_TEN2.1.2 m.44821 sp TENM_DROME 35.931 2374 1419 32 434 2777 405 2706 0 1607 TENM_DROME reviewed Teneurin-m (Tenm) (Odd Oz protein) (Tenascin-like protein) Ten-m odz CG5723 Drosophila melanogaster (Fruit fly) 2731 cell adhesion [GO:0007155]; chaeta development [GO:0022416]; compound eye corneal lens development [GO:0048058]; compound eye morphogenesis [GO:0001745]; compound eye photoreceptor development [GO:0042051]; cytoplasmic microtubule organization [GO:0031122]; maintenance of presynaptic active zone structure [GO:0048790]; motor neuron axon guidance [GO:0008045]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of locomotion [GO:0040017]; postsynaptic membrane organization [GO:0001941]; presynaptic membrane organization [GO:0097090]; R7 cell development [GO:0045467]; regulation of cell shape [GO:0008360]; regulation of homotypic cell-cell adhesion [GO:0034110]; regulation of terminal button organization [GO:2000331]; sensory perception of pain [GO:0019233]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; synaptic target attraction [GO:0016200]; synaptic target recognition [GO:0008039]; synaptic vesicle membrane organization [GO:0048499] GO:0001745; GO:0001941; GO:0005578; GO:0005737; GO:0005886; GO:0005887; GO:0007155; GO:0007274; GO:0008039; GO:0008045; GO:0008360; GO:0016200; GO:0019233; GO:0022416; GO:0030054; GO:0031005; GO:0031122; GO:0031594; GO:0034110; GO:0034116; GO:0040017; GO:0042051; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0045211; GO:0045467; GO:0046982; GO:0048058; GO:0048499; GO:0048790; GO:0050808; GO:0051124; GO:0097090; GO:2000331 0 0 0 PF05593;PF15636; O61307 CHOYP_TEN2.2.2 m.61036 sp TENM_DROME 34.612 2372 1381 33 467 2738 405 2706 0 1507 TENM_DROME reviewed Teneurin-m (Tenm) (Odd Oz protein) (Tenascin-like protein) Ten-m odz CG5723 Drosophila melanogaster (Fruit fly) 2731 cell adhesion [GO:0007155]; chaeta development [GO:0022416]; compound eye corneal lens development [GO:0048058]; compound eye morphogenesis [GO:0001745]; compound eye photoreceptor development [GO:0042051]; cytoplasmic microtubule organization [GO:0031122]; maintenance of presynaptic active zone structure [GO:0048790]; motor neuron axon guidance [GO:0008045]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of locomotion [GO:0040017]; postsynaptic membrane organization [GO:0001941]; presynaptic membrane organization [GO:0097090]; R7 cell development [GO:0045467]; regulation of cell shape [GO:0008360]; regulation of homotypic cell-cell adhesion [GO:0034110]; regulation of terminal button organization [GO:2000331]; sensory perception of pain [GO:0019233]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; synaptic target attraction [GO:0016200]; synaptic target recognition [GO:0008039]; synaptic vesicle membrane organization [GO:0048499] GO:0001745; GO:0001941; GO:0005578; GO:0005737; GO:0005886; GO:0005887; GO:0007155; GO:0007274; GO:0008039; GO:0008045; GO:0008360; GO:0016200; GO:0019233; GO:0022416; GO:0030054; GO:0031005; GO:0031122; GO:0031594; GO:0034110; GO:0034116; GO:0040017; GO:0042051; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0045211; GO:0045467; GO:0046982; GO:0048058; GO:0048499; GO:0048790; GO:0050808; GO:0051124; GO:0097090; GO:2000331 0 0 0 PF05593;PF15636; O61491 CHOYP_FLOT1.2.2 m.59727 sp FLOT1_DROME 70.142 422 126 0 2 423 4 425 0 604 FLOT1_DROME reviewed Flotillin-1 Flo1 Flo Flo-1 FLODM-1 CG8200 Drosophila melanogaster (Fruit fly) 426 multicellular organism development [GO:0007275] GO:0005198; GO:0005737; GO:0005886; GO:0007275; GO:0016600 0 0 0 PF01145;PF15975; O61492 CHOYP_LOC100371885.1.1 m.9427 sp FLOT2_DROME 66.972 436 130 2 1 422 1 436 0 608 FLOT2_DROME reviewed Flotillin-2 Flo2 Flo-2 FLODm-2 CG32593 Drosophila melanogaster (Fruit fly) 438 cell adhesion [GO:0007155]; melanotic encapsulation of foreign target [GO:0035011] GO:0005198; GO:0005737; GO:0005829; GO:0005886; GO:0007155; GO:0016600; GO:0035011 0 0 0 PF01145;PF15975; O61577 CHOYP_KTNA1.1.2 m.16373 sp KTNA1_STRPU 61.059 529 164 8 4 504 2 516 0 616 KTNA1_STRPU reviewed Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 3.6.4.3) (p60 katanin) KATNA1 Strongylocentrotus purpuratus (Purple sea urchin) 516 cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]; mitotic nuclear division [GO:0007067] GO:0000922; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007067; GO:0008568; GO:0030496; GO:0031122; GO:0051013; GO:0051301 0 0 0 PF00004;PF09336; O62698 CHOYP_PGH2.1.2 m.30907 sp PGH2_BOVIN 55.296 557 244 5 17 570 16 570 0 658 PGH2_BOVIN reviewed Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) PTGS2 COX2 Bos taurus (Bovine) 604 cellular response to interleukin-1 [GO:0071347]; cyclooxygenase pathway [GO:0019371]; inflammatory response [GO:0006954]; meiotic spindle organization [GO:0000212]; ovarian cumulus expansion [GO:0001550]; positive regulation of embryonic development [GO:0040019]; positive regulation of meiotic cell cycle process involved in oocyte maturation [GO:1904146]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of protein phosphorylation [GO:0001934]; prostaglandin biosynthetic process [GO:0001516]; regulation of blood pressure [GO:0008217]; response to oxidative stress [GO:0006979] GO:0000212; GO:0001516; GO:0001550; GO:0001934; GO:0004601; GO:0004666; GO:0005789; GO:0006954; GO:0006979; GO:0008217; GO:0019371; GO:0020037; GO:0031090; GO:0040019; GO:0046872; GO:0051213; GO:0071347; GO:1900195; GO:1904146 PATHWAY: Lipid metabolism; prostaglandin biosynthesis. 0 0 PF03098;PF00008; O62703 CHOYP_CTBL1.1.1 m.22983 sp CTBL1_BOVIN 62.039 569 197 4 16 571 1 563 0 719 CTBL1_BOVIN reviewed Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (p14) CTNNBL1 Bos taurus (Bovine) 563 apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000974; GO:0005634; GO:0005681; GO:0006397; GO:0006915; GO:0008380 0 0 0 PF08216; O70157 CHOYP_TOP3A.1.2 m.17628 sp TOP3A_MOUSE 60 950 335 11 13 923 18 961 0 1136 TOP3A_MOUSE reviewed DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha) Top3a Top3 Mus musculus (Mouse) 1003 DNA topological change [GO:0006265] GO:0003677; GO:0003916; GO:0003917; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006265; GO:0008270; GO:0016605 0 0 cd00186; PF01131;PF01751;PF01396;PF06839; O70244 CHOYP_LOC100705265.3.3 m.40296 sp CUBN_RAT 35.253 2987 1776 71 131 3051 24 2918 0 1752 CUBN_RAT reviewed Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) 3623 cholesterol metabolic process [GO:0008203]; cobalamin transport [GO:0015889]; hemoglobin import [GO:0020028]; in utero embryonic development [GO:0001701]; protein homotrimerization [GO:0070207]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to nutrient [GO:0007584]; vitamin metabolic process [GO:0006766] GO:0001701; GO:0004872; GO:0005509; GO:0005765; GO:0005905; GO:0006766; GO:0006898; GO:0007584; GO:0008203; GO:0010008; GO:0015031; GO:0015235; GO:0015889; GO:0016020; GO:0020028; GO:0030135; GO:0030492; GO:0030666; GO:0031419; GO:0031526; GO:0042802; GO:0043202; GO:0043234; GO:0070207 0 0 0 PF00431;PF00008;PF12947;PF07645; O70344 CHOYP_LOC100119507.1.1 m.62462 sp KCNQ1_CAVPO 60.077 521 183 8 83 583 103 618 0 629 KCNQ1_CAVPO reviewed Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) KCNQ1 KVLQT1 Cavia porcellus (Guinea pig) 671 inner ear development [GO:0048839]; intestinal absorption [GO:0050892]; membrane repolarization [GO:0086009]; regulation of gastric acid secretion [GO:0060453]; renal absorption [GO:0070293] GO:0005249; GO:0005251; GO:0005546; GO:0005737; GO:0005769; GO:0005783; GO:0005886; GO:0008076; GO:0015271; GO:0016323; GO:0030659; GO:0034702; GO:0045121; GO:0048839; GO:0050892; GO:0060453; GO:0070293; GO:0086009 0 0 0 PF00520;PF03520; O70496 CHOYP_CLCN7.2.3 m.47039 sp CLCN7_MOUSE 46.502 729 372 11 110 830 80 798 0 618 CLCN7_MOUSE reviewed H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) Clcn7 Clc7 Mus musculus (Mouse) 803 response to pH [GO:0009268] GO:0005247; GO:0005524; GO:0005765; GO:0009268; GO:0015297; GO:0016020; GO:0016021; GO:0031410 0 0 0 PF00571;PF00654; O70496 CHOYP_CLCN7.3.3 m.51894 sp CLCN7_MOUSE 55.468 759 308 8 19 763 59 801 0 797 CLCN7_MOUSE reviewed H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) Clcn7 Clc7 Mus musculus (Mouse) 803 response to pH [GO:0009268] GO:0005247; GO:0005524; GO:0005765; GO:0009268; GO:0015297; GO:0016020; GO:0016021; GO:0031410 0 0 0 PF00571;PF00654; O70551 CHOYP_SRPK2.1.1 m.5002 sp SRPK1_MOUSE 50.867 692 268 18 7 674 3 646 0 606 SRPK1_MOUSE reviewed SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) Srpk1 Mus musculus (Mouse) 648 cell differentiation [GO:0030154]; chromosome segregation [GO:0007059]; intracellular signal transduction [GO:0035556]; mRNA processing [GO:0006397]; negative regulation of viral genome replication [GO:0045071]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of mRNA processing [GO:0050684]; RNA splicing [GO:0008380] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005886; GO:0006397; GO:0006468; GO:0007059; GO:0008380; GO:0016363; GO:0030154; GO:0035556; GO:0044822; GO:0045070; GO:0045071; GO:0050684 0 0 0 PF00069; O70585 CHOYP_DTNA.1.1 m.20286 sp DTNB_MOUSE 49.449 635 278 10 70 680 1 616 0 620 DTNB_MOUSE reviewed Dystrobrevin beta (DTN-B) (mDTN-B) (Beta-dystrobrevin) Dtnb Mus musculus (Mouse) 659 0 GO:0005737; GO:0008270; GO:0045202 0 0 0 PF09068;PF09069;PF00569; O70628 CHOYP_LOC101077492.1.1 m.33216 sp PDE9A_MOUSE 59.806 515 184 4 1 513 1 494 0 654 PDE9A_MOUSE reviewed "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)" Pde9a Pde8b Mus musculus (Mouse) 534 cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; cGMP metabolic process [GO:0046068]; positive regulation of cardiac muscle hypertrophy [GO:0010613] GO:0005783; GO:0005794; GO:0005829; GO:0010613; GO:0019934; GO:0032587; GO:0042383; GO:0043204; GO:0046068; GO:0046069; GO:0046872; GO:0047555; GO:0048471 "PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1." 0 0 PF00233; O70628 CHOYP_LOC571737.1.1 m.27894 sp PDE9A_MOUSE 60.757 502 181 3 1 494 1 494 0 642 PDE9A_MOUSE reviewed "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)" Pde9a Pde8b Mus musculus (Mouse) 534 cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; cGMP metabolic process [GO:0046068]; positive regulation of cardiac muscle hypertrophy [GO:0010613] GO:0005783; GO:0005794; GO:0005829; GO:0010613; GO:0019934; GO:0032587; GO:0042383; GO:0043204; GO:0046068; GO:0046069; GO:0046872; GO:0047555; GO:0048471 "PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1." 0 0 PF00233; O73925 CHOYP_KCNQ1.1.1 m.31995 sp KCNQ1_SQUAC 55.537 614 233 11 2 589 16 615 0 639 KCNQ1_SQUAC reviewed Potassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1) KCNQ1 Squalus acanthias (Spiny dogfish) 660 inner ear development [GO:0048839]; intestinal absorption [GO:0050892]; membrane repolarization [GO:0086009]; regulation of gastric acid secretion [GO:0060453]; renal absorption [GO:0070293] GO:0005249; GO:0005251; GO:0005546; GO:0005737; GO:0005783; GO:0005886; GO:0008076; GO:0015271; GO:0016323; GO:0030659; GO:0034702; GO:0045121; GO:0048839; GO:0050892; GO:0060453; GO:0070293; GO:0086009 0 0 0 PF00520;PF03520; O75027 CHOYP_ABCB7.1.1 m.16069 sp ABCB7_HUMAN 48.425 603 306 3 93 691 114 715 0 592 ABCB7_HUMAN reviewed "ATP-binding cassette sub-family B member 7, mitochondrial (ATP-binding cassette transporter 7) (ABC transporter 7 protein)" ABCB7 ABC7 Homo sapiens (Human) 752 cellular iron ion homeostasis [GO:0006879]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005524; GO:0005739; GO:0005743; GO:0006810; GO:0006879; GO:0015232; GO:0016021; GO:0042626; GO:0055085 0 0 0 PF00664;PF00005; O75131 CHOYP_BRAFLDRAFT_118500.1.1 m.46374 sp CPNE3_HUMAN 52.542 531 240 8 10 538 6 526 0 544 CPNE3_HUMAN reviewed Copine-3 (Copine III) CPNE3 CPN3 KIAA0636 Homo sapiens (Human) 537 cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; glycerophospholipid biosynthetic process [GO:0046474]; lipid metabolic process [GO:0006629]; positive regulation of cell migration [GO:0030335]; vesicle-mediated transport [GO:0016192] GO:0004674; GO:0005215; GO:0005544; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005925; GO:0006629; GO:0016192; GO:0030054; GO:0030335; GO:0030971; GO:0038128; GO:0044822; GO:0046474; GO:0048306; GO:0070062; GO:0071277; GO:0071363 0 0 0 PF00168;PF07002; O75131 CHOYP_BRAFLDRAFT_120970.1.1 m.63798 sp CPNE3_HUMAN 54.972 533 230 7 12 542 2 526 0 571 CPNE3_HUMAN reviewed Copine-3 (Copine III) CPNE3 CPN3 KIAA0636 Homo sapiens (Human) 537 cellular response to calcium ion [GO:0071277]; cellular response to growth factor stimulus [GO:0071363]; ERBB2 signaling pathway [GO:0038128]; glycerophospholipid biosynthetic process [GO:0046474]; lipid metabolic process [GO:0006629]; positive regulation of cell migration [GO:0030335]; vesicle-mediated transport [GO:0016192] GO:0004674; GO:0005215; GO:0005544; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005925; GO:0006629; GO:0016192; GO:0030054; GO:0030335; GO:0030971; GO:0038128; GO:0044822; GO:0046474; GO:0048306; GO:0070062; GO:0071277; GO:0071363 0 0 0 PF00168;PF07002; O75165 CHOYP_DJC13.1.1 m.46117 sp DJC13_HUMAN 66.076 2258 723 15 1 2240 1 2233 0 3142 DJC13_HUMAN reviewed DnaJ homolog subfamily C member 13 (Required for receptor-mediated endocytosis 8) (RME-8) DNAJC13 KIAA0678 RME8 Homo sapiens (Human) 2243 endosome organization [GO:0007032]; osteoblast differentiation [GO:0001649]; protein transport [GO:0015031]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of early endosome to recycling endosome transport [GO:1902954] GO:0001649; GO:0005737; GO:0005765; GO:0007032; GO:0010008; GO:0015031; GO:0016020; GO:0031901; GO:0043231; GO:0070062; GO:1902954; GO:2000641 0 0 cd06257; PF00226;PF14237; O75182 CHOYP_BRAFLDRAFT_97881.1.1 m.46581 sp SIN3B_HUMAN 45.462 1223 490 25 112 1281 41 1139 0 1009 SIN3B_HUMAN reviewed Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b) SIN3B KIAA0700 Homo sapiens (Human) 1162 "cardiac muscle tissue development [GO:0048738]; cellular lipid metabolic process [GO:0044255]; histone deacetylation [GO:0016575]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; skeletal muscle tissue development [GO:0007519]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000805; GO:0000806; GO:0001106; GO:0001741; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0007519; GO:0016575; GO:0016580; GO:0030849; GO:0044255; GO:0048738 0 0 0 PF02671;PF08295;PF16879; O75417 CHOYP_BRAFLDRAFT_251779.2.2 m.17171 sp DPOLQ_HUMAN 58.983 846 323 6 225 1060 67 898 0 1048 DPOLQ_HUMAN reviewed DNA polymerase theta (EC 2.7.7.7) (DNA polymerase eta) POLQ POLH Homo sapiens (Human) 2590 base-excision repair [GO:0006284]; cellular response to DNA damage stimulus [GO:0006974]; DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0000724; GO:0003682; GO:0003684; GO:0003887; GO:0005524; GO:0005654; GO:0005694; GO:0006261; GO:0006281; GO:0006284; GO:0006302; GO:0006974; GO:0016446; GO:0043142; GO:0051260; GO:0051575; GO:0097681; GO:2000042 0 0 0 PF00270;PF00476;PF00271; O75419 CHOYP_LOC753011.1.1 m.12713 sp CDC45_HUMAN 50.439 569 274 4 1 565 1 565 0 598 CDC45_HUMAN reviewed Cell division control protein 45 homolog (PORC-PI-1) CDC45 CDC45L CDC45L2 UNQ374/PRO710 Homo sapiens (Human) 566 DNA replication [GO:0006260]; DNA replication checkpoint [GO:0000076]; DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic DNA replication preinitiation complex assembly [GO:1902977]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267]; regulation of chromatin silencing at telomere [GO:0031938]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083] GO:0000076; GO:0000082; GO:0000083; GO:0000727; GO:0003682; GO:0003688; GO:0003697; GO:0005634; GO:0005654; GO:0005656; GO:0005737; GO:0005813; GO:0006260; GO:0006267; GO:0006270; GO:0031261; GO:0031298; GO:0031938; GO:0043138; GO:1900087; GO:1902977 0 0 0 PF02724; O75439 CHOYP_ISCW_ISCW001592.1.2 m.20852 sp MPPB_HUMAN 59.121 455 172 2 45 494 43 488 0 564 MPPB_HUMAN reviewed Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52) PMPCB MPPB Homo sapiens (Human) 489 "aerobic respiration [GO:0009060]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; protein processing [GO:0016485]" GO:0004222; GO:0005750; GO:0005759; GO:0006122; GO:0008270; GO:0009060; GO:0016485 0 0 0 PF00675;PF05193; O75439 CHOYP_ISCW_ISCW001592.2.2 m.39326 sp MPPB_HUMAN 58.901 455 172 3 33 481 43 488 0 558 MPPB_HUMAN reviewed Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52) PMPCB MPPB Homo sapiens (Human) 489 "aerobic respiration [GO:0009060]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; protein processing [GO:0016485]" GO:0004222; GO:0005750; GO:0005759; GO:0006122; GO:0008270; GO:0009060; GO:0016485 0 0 0 PF00675;PF05193; O75460 CHOYP_BRAFLDRAFT_118819.1.2 m.29565 sp ERN1_HUMAN 67.677 396 124 2 140 531 566 961 0 561 ERN1_HUMAN reviewed Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ERN1 IRE1 Homo sapiens (Human) 977 "activation of JUN kinase activity [GO:0007257]; activation of signaling protein activity involved in unfolded protein response [GO:0006987]; cell cycle arrest [GO:0007050]; cellular response to glucose stimulus [GO:0071333]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell proliferation [GO:0001935]; insulin metabolic process [GO:1901142]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; mRNA catabolic process [GO:0006402]; mRNA cleavage [GO:0006379]; mRNA endonucleolytic cleavage involved in unfolded protein response [GO:0070055]; mRNA splicing, via endonucleolytic cleavage and ligation [GO:0070054]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine trans-autophosphorylation [GO:1990579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of RNA splicing [GO:0033120]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of macroautophagy [GO:0016241]; regulation of transcription, DNA-templated [GO:0006355]; response to endoplasmic reticulum stress [GO:0034976]; transcription, DNA-templated [GO:0006351]" GO:0000287; GO:0001935; GO:0004521; GO:0004674; GO:0005524; GO:0005637; GO:0005737; GO:0005739; GO:0005783; GO:0005789; GO:0006351; GO:0006355; GO:0006379; GO:0006402; GO:0006468; GO:0006987; GO:0007050; GO:0007257; GO:0016241; GO:0019899; GO:0030176; GO:0030544; GO:0033120; GO:0034976; GO:0035924; GO:0036289; GO:0036498; GO:0042802; GO:0042803; GO:0043531; GO:0046777; GO:0051879; GO:0070054; GO:0070055; GO:0070059; GO:0071333; GO:1900103; GO:1901142; GO:1990332; GO:1990579; GO:1990597; GO:1990604; GO:1990630 0 0 0 PF00069;PF06479; O75534 CHOYP_LOC100377755.1.1 m.1005 sp CSDE1_HUMAN 46.923 780 383 17 43 805 25 790 0 677 CSDE1_HUMAN reviewed Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR) CSDE1 D1S155E KIAA0885 NRU UNR Homo sapiens (Human) 798 "male gonad development [GO:0008584]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005737; GO:0005743; GO:0005794; GO:0005886; GO:0006355; GO:0008584; GO:0044822; GO:0070937; GO:0070966 0 0 cd04458; PF00313;PF12901; O75581 CHOYP_LRP6.3.6 m.21850 sp LRP6_HUMAN 53.596 1627 661 35 16 1581 19 1612 0 1681 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; O75592 CHOYP_MYCB2.1.2 m.13017 sp MYCB2_HUMAN 48.816 2618 1171 44 81 2578 101 2669 0 2340 MYCB2_HUMAN reviewed E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) 4640 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016020; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF00630;PF08005;PF00415;PF08239;PF13639; O75643 CHOYP_U520.1.1 m.7087 sp U520_HUMAN 77.338 2149 471 8 1 2146 1 2136 0 3476 U520_HUMAN reviewed U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) SNRNP200 ASCC3L1 HELIC2 KIAA0788 Homo sapiens (Human) 2136 "cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]" GO:0000354; GO:0000398; GO:0001649; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0005682; GO:0008026; GO:0016020; GO:0042802; GO:0044822; GO:0071013 0 0 0 PF00270;PF00271;PF02889; O75691 CHOYP_UTP20.2.4 m.1508 sp UTP20_HUMAN 38.21 1743 986 19 1 1673 1061 2782 0 1176 UTP20_HUMAN reviewed Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) 2785 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of cell proliferation [GO:0008285]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0008285; GO:0030686; GO:0030688; GO:0032040; GO:0044822 0 0 0 PF07539; O75694 CHOYP_BRAFLDRAFT_225253.1.1 m.9264 sp NU155_HUMAN 49.818 1377 638 13 13 1342 20 1390 0 1373 NU155_HUMAN reviewed Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) NUP155 KIAA0791 Homo sapiens (Human) 1391 atrial cardiac muscle cell action potential [GO:0086014]; gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; nuclear envelope organization [GO:0006998]; protein import into nucleus [GO:0006606]; protein sumoylation [GO:0016925]; protein targeting to nuclear inner membrane [GO:0036228]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; RNA export from nucleus [GO:0006405]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0000972; GO:0005215; GO:0005635; GO:0006405; GO:0006406; GO:0006409; GO:0006606; GO:0006998; GO:0007077; GO:0010827; GO:0016020; GO:0016032; GO:0016925; GO:0017056; GO:0019083; GO:0031047; GO:0031965; GO:0036228; GO:0044611; GO:0075733; GO:0086014; GO:1900034 0 0 0 PF03177;PF08801; O75808 CHOYP_LOC100879981.1.1 m.57826 sp CAN15_HUMAN 49.288 702 317 10 543 1217 397 1086 0 669 CAN15_HUMAN reviewed Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) CAPN15 SOLH Homo sapiens (Human) 1086 0 GO:0003700; GO:0004198; GO:0005737; GO:0008233; GO:0008234; GO:0008270 0 0 0 PF00648;PF00641; O75808 CHOYP_LOC101159619.1.1 m.12684 sp CAN15_HUMAN 49.288 702 317 10 519 1193 397 1086 0 667 CAN15_HUMAN reviewed Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) CAPN15 SOLH Homo sapiens (Human) 1086 0 GO:0003700; GO:0004198; GO:0005737; GO:0008233; GO:0008234; GO:0008270 0 0 0 PF00648;PF00641; O75912 CHOYP_DGKZA.2.2 m.35575 sp DGKI_HUMAN 51.116 986 363 18 325 1261 135 1050 0 972 DGKI_HUMAN reviewed Diacylglycerol kinase iota (DAG kinase iota) (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) DGKI Homo sapiens (Human) 1065 "excitatory postsynaptic potential [GO:0060079]; habituation [GO:0046959]; intracellular signal transduction [GO:0035556]; neurotransmitter secretion [GO:0007269]; platelet activation [GO:0030168]; positive regulation of Ras protein signal transduction [GO:0046579]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; regulation of long term synaptic depression [GO:1900452]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0004143; GO:0005095; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0007205; GO:0007269; GO:0008021; GO:0030168; GO:0032045; GO:0035556; GO:0043025; GO:0043197; GO:0043234; GO:0043679; GO:0045202; GO:0046579; GO:0046872; GO:0046959; GO:0048471; GO:0048786; GO:0051966; GO:0060076; GO:0060079; GO:0097060; GO:1900452 0 0 0 PF12796;PF00130;PF00609;PF00781; O75923 CHOYP_MYOF.1.3 m.1614 sp DYSF_HUMAN 47.788 2080 982 33 3 2014 2 2045 0 1875 DYSF_HUMAN reviewed Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) DYSF FER1L1 Homo sapiens (Human) 2080 muscle contraction [GO:0006936]; plasma membrane repair [GO:0001778]; vesicle fusion [GO:0006906] GO:0001778; GO:0005509; GO:0005543; GO:0005544; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0006906; GO:0006936; GO:0016021; GO:0030027; GO:0030139; GO:0030315; GO:0030659; GO:0042383; GO:0070062 0 0 0 PF00168;PF08165;PF08150;PF08151;PF16165; O75970 CHOYP_LOC100165785.1.1 m.288 sp MPDZ_HUMAN 49.501 701 296 12 1147 1800 1141 1830 0 605 MPDZ_HUMAN reviewed Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) 2070 cell adhesion [GO:0007155]; myelination [GO:0042552]; viral process [GO:0016032] GO:0005737; GO:0005923; GO:0007155; GO:0008022; GO:0014069; GO:0016032; GO:0016324; GO:0016327; GO:0030425; GO:0031410; GO:0042552; GO:0043220; GO:0045211 0 0 0 PF09045;PF16667;PF00595; O75970 CHOYP_MPDZ.2.3 m.43841 sp MPDZ_HUMAN 48.737 950 407 18 1378 2267 1141 2070 0 813 MPDZ_HUMAN reviewed Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) 2070 cell adhesion [GO:0007155]; myelination [GO:0042552]; viral process [GO:0016032] GO:0005737; GO:0005923; GO:0007155; GO:0008022; GO:0014069; GO:0016032; GO:0016324; GO:0016327; GO:0030425; GO:0031410; GO:0042552; GO:0043220; GO:0045211 0 0 0 PF09045;PF16667;PF00595; O75970 CHOYP_MPDZ.3.3 m.51236 sp MPDZ_HUMAN 48.469 947 414 17 1418 2307 1141 2070 0 813 MPDZ_HUMAN reviewed Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) 2070 cell adhesion [GO:0007155]; myelination [GO:0042552]; viral process [GO:0016032] GO:0005737; GO:0005923; GO:0007155; GO:0008022; GO:0014069; GO:0016032; GO:0016324; GO:0016327; GO:0030425; GO:0031410; GO:0042552; GO:0043220; GO:0045211 0 0 0 PF09045;PF16667;PF00595; O75976 CHOYP_LOC100533325.1.1 m.55617 sp CBPD_HUMAN 42.431 1275 603 26 48 1237 55 1283 0 984 CBPD_HUMAN reviewed Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) CPD Homo sapiens (Human) 1380 peptide metabolic process [GO:0006518]; protein processing [GO:0016485] GO:0004181; GO:0004185; GO:0005615; GO:0005634; GO:0005802; GO:0005886; GO:0006518; GO:0008270; GO:0016020; GO:0016021; GO:0016485; GO:0070062 0 0 0 PF00246; O76094 CHOYP_SRP72.1.1 m.60789 sp SRP72_HUMAN 49.16 655 310 8 9 653 11 652 0 580 SRP72_HUMAN reviewed Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein) SRP72 Homo sapiens (Human) 671 response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005047; GO:0005730; GO:0005737; GO:0005783; GO:0005786; GO:0005829; GO:0005886; GO:0006614; GO:0008312; GO:0042493; GO:0044822 0 0 0 PF08492;PF17004;PF13181; O76924 CHOYP_ARI2.1.1 m.34963 sp ARI2_DROME 61.57 484 155 4 76 529 25 507 0 634 ARI2_DROME reviewed Protein ariadne-2 (Ari-2) ari-2 ari2 TRIAD1 CG5709 Drosophila melanogaster (Fruit fly) 509 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0004842; GO:0005634; GO:0005737; GO:0008270; GO:0031624; GO:0032436; GO:0042787; GO:0061630 0 0 0 PF01485; O77237 CHOYP_PELI.1.1 m.23737 sp PELI_DROME 60.671 417 161 2 24 439 10 424 0 536 PELI_DROME reviewed Protein pellino Pli CG5212 Drosophila melanogaster (Fruit fly) 424 immune response [GO:0006955]; negative regulation of antimicrobial humoral response [GO:0008348]; negative regulation of Toll signaling pathway [GO:0045751]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; regulation of phosphorylation [GO:0042325]; Toll signaling pathway [GO:0008063] GO:0005737; GO:0005886; GO:0006955; GO:0008063; GO:0008348; GO:0019207; GO:0042325; GO:0045751; GO:1902524 0 0 0 PF04710; O77622 CHOYP_LOC594665.1.1 m.8449 sp TCPZ_RABIT 77.024 531 122 0 1 531 1 531 0 858 TCPZ_RABIT reviewed T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) CCT6 Oryctolagus cuniculus (Rabbit) 531 chaperone mediated protein folding independent of cofactor [GO:0051086]; protein folding [GO:0006457] GO:0005524; GO:0005829; GO:0005832; GO:0005874; GO:0006457; GO:0044822; GO:0051086; GO:0070062 0 0 cd03342; PF00118; O88281 CHOYP_MEGF6.27.59 m.36930 sp MEGF6_RAT 44.831 1006 506 6 1 959 557 1560 0 808 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O88281 CHOYP_contig_049898 m.59293 sp MEGF6_RAT 44.264 1046 537 9 1 1041 556 1560 0 824 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O88307 CHOYP_SORL.3.3 m.58779 sp SORL_MOUSE 32.634 2289 1264 68 69 2219 67 2215 0 1081 SORL_MOUSE reviewed Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) Sorl1 Mus musculus (Mouse) 2215 cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897]; lipid transport [GO:0006869]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of beta-amyloid formation [GO:1902430]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein oligomerization [GO:0032460]; negative regulation of tau-protein kinase activity [GO:1902948]; positive regulation of choline O-acetyltransferase activity [GO:1902771]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to Golgi [GO:0000042]; protein targeting to lysosome [GO:0006622]; regulation of smooth muscle cell migration [GO:0014910] GO:0000042; GO:0001540; GO:0005615; GO:0005641; GO:0005768; GO:0005769; GO:0005783; GO:0005794; GO:0005802; GO:0006605; GO:0006622; GO:0006869; GO:0006892; GO:0006897; GO:0008203; GO:0014910; GO:0016020; GO:0016021; GO:0030169; GO:0030306; GO:0031985; GO:0032091; GO:0032460; GO:0034362; GO:0043407; GO:0045053; GO:0045732; GO:0048471; GO:0050768; GO:0051604; GO:0055037; GO:0070062; GO:0070863; GO:1901215; GO:1902430; GO:1902771; GO:1902948; GO:1902953; GO:1902955; GO:1902960; GO:1902963; GO:1902966; GO:1902997; GO:2001137 0 0 0 PF00041;PF00057;PF00058;PF15902;PF15901; O88327 CHOYP_LOC100371831.1.1 m.11775 sp CTNL1_MOUSE 45.571 700 350 9 13 702 29 707 0 576 CTNL1_MOUSE reviewed Alpha-catulin (Alpha-catenin-related protein) (ACRP) (Catenin alpha-like protein 1) Ctnnal1 Catnal1 Mus musculus (Mouse) 731 cell adhesion [GO:0007155]; Rho protein signal transduction [GO:0007266] GO:0005829; GO:0005856; GO:0005886; GO:0007155; GO:0007266 0 0 0 PF01044; O88427 CHOYP_LOC100864734.1.2 m.8165 sp CAC1H_MOUSE 51.595 1285 490 25 756 2019 770 1943 0 1092 CAC1H_MOUSE reviewed Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Kiaa1120 Mus musculus (Mouse) 2365 aldosterone biosynthetic process [GO:0032342]; calcium ion import [GO:0070509]; calcium ion transport [GO:0006816]; cortisol biosynthetic process [GO:0034651]; ion transmembrane transport [GO:0034220]; membrane depolarization during action potential [GO:0086010]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of membrane potential [GO:0042391] GO:0005261; GO:0005886; GO:0005891; GO:0005901; GO:0006816; GO:0008332; GO:0016021; GO:0032342; GO:0034220; GO:0034651; GO:0042383; GO:0042391; GO:0045956; GO:0046872; GO:0070509; GO:0086010; GO:0097110; GO:2000344 0 0 0 PF00520; O88427 CHOYP_LOC100864734.2.2 m.11381 sp CAC1H_MOUSE 51.471 1292 493 26 340 1608 770 1950 0 1092 CAC1H_MOUSE reviewed Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Kiaa1120 Mus musculus (Mouse) 2365 aldosterone biosynthetic process [GO:0032342]; calcium ion import [GO:0070509]; calcium ion transport [GO:0006816]; cortisol biosynthetic process [GO:0034651]; ion transmembrane transport [GO:0034220]; membrane depolarization during action potential [GO:0086010]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of membrane potential [GO:0042391] GO:0005261; GO:0005886; GO:0005891; GO:0005901; GO:0006816; GO:0008332; GO:0016021; GO:0032342; GO:0034220; GO:0034651; GO:0042383; GO:0042391; GO:0045956; GO:0046872; GO:0070509; GO:0086010; GO:0097110; GO:2000344 0 0 0 PF00520; O88444 CHOYP_APLA.1.2 m.191 sp ADCY1_MOUSE 43.719 995 510 17 91 1067 94 1056 0 812 ADCY1_MOUSE reviewed Adenylate cyclase type 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase) Adcy1 Mus musculus (Mouse) 1118 activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; axonogenesis [GO:0007409]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933]; cellular response to calcium ion [GO:0071277]; cellular response to forskolin [GO:1904322]; circadian rhythm [GO:0007623]; long-term memory [GO:0007616]; regulation of circadian rhythm [GO:0042752]; response to drug [GO:0042493]; response to lithium ion [GO:0010226] GO:0004016; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0006171; GO:0007189; GO:0007190; GO:0007193; GO:0007409; GO:0007616; GO:0007623; GO:0008294; GO:0010226; GO:0019933; GO:0042493; GO:0042752; GO:0045121; GO:0046872; GO:0070062; GO:0071277; GO:1904322 0 0 0 PF16214;PF00211; O88487 CHOYP_DC1I2.1.3 m.25743 sp DC1I2_MOUSE 58.07 632 232 5 2 629 5 607 0 696 DC1I2_MOUSE reviewed "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" Dync1i2 Dnci2 Dncic2 Mus musculus (Mouse) 612 microtubule-based movement [GO:0007018]; transport [GO:0006810] GO:0003774; GO:0005737; GO:0005868; GO:0005874; GO:0006810; GO:0007018; GO:0031982 0 0 0 PF11540;PF00400; O88487 CHOYP_DC1I2.3.3 m.57898 sp DC1I2_MOUSE 59.738 611 235 3 2 609 5 607 0 705 DC1I2_MOUSE reviewed "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" Dync1i2 Dnci2 Dncic2 Mus musculus (Mouse) 612 microtubule-based movement [GO:0007018]; transport [GO:0006810] GO:0003774; GO:0005737; GO:0005868; GO:0005874; GO:0006810; GO:0007018; GO:0031982 0 0 0 PF11540;PF00400; O88491 CHOYP_WHSC1.1.1 m.15308 sp NSD1_MOUSE 56.241 665 284 5 545 1205 1443 2104 0 831 NSD1_MOUSE reviewed "Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)" Nsd1 Mus musculus (Mouse) 2588 "gastrulation with mouth forming second [GO:0001702]; histone methylation [GO:0016571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of histone H3-K36 methylation [GO:0000414]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000414; GO:0000979; GO:0001702; GO:0003682; GO:0003712; GO:0003714; GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0008270; GO:0016571; GO:0030331; GO:0033135; GO:0035097; GO:0042054; GO:0042799; GO:0042974; GO:0045893; GO:0046965; GO:0046966; GO:0046975; GO:0050681; GO:1903025 0 0 0 PF00855;PF00856; O88529 CHOYP_BMAL1.1.1 m.6564 sp BMAL1_MESAU 48.554 657 271 17 13 661 29 626 0 554 BMAL1_MESAU reviewed Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) ARNTL BMAL1 Mesocricetus auratus (Golden hamster) 626 "circadian regulation of gene expression [GO:0032922]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription, DNA-templated [GO:0045892]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of transcription, DNA-templated [GO:0006355]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000976; GO:0001047; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0006355; GO:0007283; GO:0016605; GO:0032007; GO:0032922; GO:0033391; GO:0042634; GO:0042753; GO:0043161; GO:0043565; GO:0045599; GO:0045892; GO:0045893; GO:0050767; GO:0050796; GO:0051726; GO:0051775; GO:0070888; GO:0090263; GO:0090403; GO:2000074; GO:2000323; GO:2000772; GO:2001016 0 0 0 PF00010;PF00989; O88544 CHOYP_CSN4.1.1 m.18561 sp CSN4_MOUSE 77.751 409 87 2 3 410 1 406 0 655 CSN4_MOUSE reviewed COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) Cops4 Csn4 Mus musculus (Mouse) 406 cullin deneddylation [GO:0010388]; protein deneddylation [GO:0000338] GO:0000338; GO:0005634; GO:0005654; GO:0005829; GO:0008021; GO:0008180; GO:0010388; GO:0030054; GO:0070062 0 0 0 PF01399; O88554 CHOYP_LOC100495846.1.1 m.11305 sp PARP2_MOUSE 56.53 536 216 7 213 740 29 555 0 632 PARP2_MOUSE reviewed Poly [ADP-ribose] polymerase 2 (PARP-2) (mPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) Parp2 Adprt2 Adprtl2 Aspartl2 Mus musculus (Mouse) 559 base-excision repair [GO:0006284]; DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; extrinsic apoptotic signaling pathway [GO:0097191]; lagging strand elongation [GO:0006273]; protein ADP-ribosylation [GO:0006471] GO:0003677; GO:0003910; GO:0003950; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006273; GO:0006281; GO:0006284; GO:0006471; GO:0051103; GO:0097191 0 0 0 PF00644;PF02877;PF05406; O88986 CHOYP_ISCW_ISCW015295.1.1 m.22192 sp KBL_MOUSE 66.749 406 134 1 49 454 6 410 0 574 KBL_MOUSE reviewed "2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (AKB ligase) (EC 2.3.1.29) (Aminoacetone synthase) (Glycine acetyltransferase)" Gcat Kbl Mus musculus (Mouse) 416 biosynthetic process [GO:0009058]; L-threonine catabolic process to glycine [GO:0019518] GO:0005654; GO:0005739; GO:0005743; GO:0008890; GO:0009058; GO:0019518; GO:0030170 PATHWAY: Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2. 0 0 PF00155; O89000 CHOYP_BRAFLDRAFT_129513.1.1 m.51276 sp DPYD_RAT 73.164 1021 269 3 27 1045 4 1021 0 1592 DPYD_RAT reviewed Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase) Dpyd DPD Rattus norvegicus (Rat) 1025 aging [GO:0007568]; beta-alanine biosynthetic process [GO:0019483]; circadian rhythm [GO:0007623]; pyrimidine nucleobase catabolic process [GO:0006208]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; thymidine catabolic process [GO:0006214]; uracil catabolic process [GO:0006212]; uracil metabolic process [GO:0019860] GO:0002058; GO:0004159; GO:0005506; GO:0005737; GO:0005829; GO:0006208; GO:0006212; GO:0006214; GO:0007568; GO:0007584; GO:0007623; GO:0014070; GO:0017113; GO:0019483; GO:0019860; GO:0042493; GO:0042803; GO:0050661; GO:0051384; GO:0051539; GO:0071949 PATHWAY: Amino-acid biosynthesis; beta-alanine biosynthesis. 0 0 PF01180;PF14691;PF07992; O89016 CHOYP_ABCD4.1.2 m.9912 sp ABCD4_MOUSE 45.667 600 313 3 13 608 13 603 0 553 ABCD4_MOUSE reviewed ATP-binding cassette sub-family D member 4 (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69) Abcd4 Pxmp1l Mus musculus (Mouse) 606 cobalamin metabolic process [GO:0009235] GO:0005524; GO:0005789; GO:0009235; GO:0016021; GO:0042626 0 0 0 PF06472;PF00005; O93257 CHOYP_BRAFLDRAFT_281658.1.1 m.6266 sp XRCC6_CHICK 46.959 592 297 8 45 631 50 629 0 565 XRCC6_CHICK reviewed X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP/AP lyase Ku70) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (DNA repair protein XRCC6) (Ku autoantigen protein p70 homolog) (Ku70) XRCC6 G22P1 KU70 Gallus gallus (Chicken) 632 "cellular response to gamma radiation [GO:0071480]; cellular response to X-ray [GO:0071481]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of transcription, DNA-templated [GO:0045892]; telomere maintenance [GO:0000723]; transcription, DNA-templated [GO:0006351]" GO:0000723; GO:0000784; GO:0003684; GO:0004003; GO:0005524; GO:0005654; GO:0006303; GO:0006310; GO:0006351; GO:0032508; GO:0042162; GO:0043564; GO:0045892; GO:0051575; GO:0070419; GO:0071480; GO:0071481 0 0 0 PF02735;PF03730;PF03731;PF02037; O93309 CHOYP_SMC3.1.1 m.65133 sp SMC3_XENLA 62.038 1217 440 5 1 1203 1 1209 0 1517 SMC3_XENLA reviewed Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) smc3 smc3l1 Xenopus laevis (African clawed frog) 1209 cell division [GO:0051301]; DNA repair [GO:0006281]; meiotic cell cycle [GO:0051321]; mitotic sister chromatid cohesion [GO:0007064]; regulation of DNA replication [GO:0006275] GO:0000775; GO:0000785; GO:0003682; GO:0005524; GO:0005634; GO:0006275; GO:0006281; GO:0007064; GO:0008280; GO:0030893; GO:0051301; GO:0051321 0 0 0 PF06470;PF02463; O93530 CHOYP_LOC100179894.1.1 m.17437 sp WRN_XENLA 42.343 862 434 16 242 1061 467 1307 0 673 WRN_XENLA reviewed Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-) (Focus-forming activity 1) (FFA-1) wrn ffa1 Xenopus laevis (African clawed frog) 1436 DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] GO:0000287; GO:0003677; GO:0005524; GO:0005634; GO:0006259; GO:0006260; GO:0006281; GO:0006310; GO:0008408; GO:0030145; GO:0043140 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; O94759 CHOYP_LOC584520.2.2 m.55330 sp TRPM2_HUMAN 33.414 1646 858 35 58 1669 62 1503 0 815 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; O94759 CHOYP_NEMVEDRAFT_V1G248535.1.2 m.10116 sp TRPM2_HUMAN 33.833 1602 861 36 58 1620 62 1503 0 811 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; O94762 CHOYP_RECQL5.1.1 m.25204 sp RECQ5_HUMAN 49.131 633 294 7 4 636 15 619 0 606 RECQ5_HUMAN reviewed "ATP-dependent DNA helicase Q5 (EC 3.6.4.12) (DNA helicase, RecQ-like type 5) (RecQ5) (RecQ protein-like 5)" RECQL5 RECQ5 Homo sapiens (Human) 991 cell division [GO:0051301]; chromosome separation [GO:0051304]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mitotic nuclear division [GO:0007067]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244] GO:0000724; GO:0000993; GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006259; GO:0006260; GO:0006281; GO:0007067; GO:0009378; GO:0016591; GO:0034244; GO:0043140; GO:0051301; GO:0051304 0 0 0 PF00270;PF00271;PF06959;PF16124; O94805 CHOYP_ACL6B.1.1 m.62588 sp ACL6B_HUMAN 66.667 354 116 2 14 366 65 417 0 518 ACL6B_HUMAN reviewed Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpNalpha) (BRG1-associated factor 53B) (BAF53B) ACTL6B ACTL6 BAF53B Homo sapiens (Human) 426 "chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spinal cord development [GO:0021510]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005200; GO:0005634; GO:0005730; GO:0006325; GO:0006338; GO:0006351; GO:0006357; GO:0016514; GO:0016569; GO:0021510; GO:0071565 0 0 0 PF00022; O94806 CHOYP_KPCD3.1.1 m.10808 sp KPCD3_HUMAN 59.668 843 294 10 5 827 55 871 0 1008 KPCD3_HUMAN reviewed Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu) PRKD3 EPK2 PRKCN Homo sapiens (Human) 890 intracellular signal transduction [GO:0035556]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein phosphorylation [GO:0006468] GO:0004697; GO:0005524; GO:0005654; GO:0005737; GO:0006468; GO:0007205; GO:0016020; GO:0016301; GO:0035556; GO:0046872 0 0 0 PF00130;PF00169;PF00069; O94812 CHOYP_ISCW_ISCW005596.1.1 m.60561 sp BAIP3_HUMAN 33.892 1133 680 18 83 1208 111 1181 0 608 BAIP3_HUMAN reviewed BAI1-associated protein 3 (BAP3) BAIAP3 KIAA0734 Homo sapiens (Human) 1187 G-protein coupled receptor signaling pathway [GO:0007186]; neurotransmitter secretion [GO:0007269] GO:0007186; GO:0007269; GO:0008022; GO:0098793 0 0 0 PF00168;PF10540; O94889 CHOYP_LOC100370157.1.1 m.53968 sp KLH18_HUMAN 59.964 562 225 0 4 565 10 571 0 729 KLH18_HUMAN reviewed Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) 574 protein ubiquitination [GO:0016567] GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; O94925 CHOYP_LOC100876457.1.1 m.14756 sp GLSK_HUMAN 55.814 516 216 2 83 598 136 639 0 618 GLSK_HUMAN reviewed "Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase)" GLS GLS1 KIAA0838 Homo sapiens (Human) 669 cellular amino acid biosynthetic process [GO:0008652]; chemical synaptic transmission [GO:0007268]; glutamate biosynthetic process [GO:0006537]; glutamate secretion [GO:0014047]; glutamine catabolic process [GO:0006543]; protein homotetramerization [GO:0051289]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; suckling behavior [GO:0001967] GO:0001967; GO:0002087; GO:0004359; GO:0005739; GO:0005759; GO:0005829; GO:0006537; GO:0006543; GO:0007268; GO:0008652; GO:0014047; GO:0051289 0 0 0 PF12796;PF04960; O94966 CHOYP_UBP19.1.1 m.55642 sp UBP19_HUMAN 41.045 804 422 17 34 799 115 904 0 583 UBP19_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 19 (EC 3.4.19.12) (Deubiquitinating enzyme 19) (Ubiquitin thioesterase 19) (Ubiquitin-specific-processing protease 19) (Zinc finger MYND domain-containing protein 9) USP19 KIAA0891 ZMYND9 Homo sapiens (Human) 1318 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of skeletal muscle tissue development [GO:0048642]; positive regulation of cell cycle process [GO:0090068]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of cellular response to hypoxia [GO:1900037]; regulation of ERAD pathway [GO:1904292]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976] GO:0004843; GO:0005789; GO:0005829; GO:0016021; GO:0016579; GO:0030433; GO:0031647; GO:0034976; GO:0046872; GO:0048642; GO:0050821; GO:0051879; GO:0090068; GO:1900037; GO:1901799; GO:1904292; GO:1990380 0 0 0 PF04969;PF00443;PF01753; O95163 CHOYP_ELP1.2.2 m.29114 sp ELP1_HUMAN 47.926 1350 654 19 1 1319 1 1332 0 1212 ELP1_HUMAN reviewed Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150) IKBKAP ELP1 IKAP Homo sapiens (Human) 1332 immune response [GO:0006955]; positive regulation of cell migration [GO:0030335]; protein complex assembly [GO:0006461]; protein phosphorylation [GO:0006468]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]; tRNA wobble uridine modification [GO:0002098] GO:0000123; GO:0002098; GO:0004871; GO:0005730; GO:0005737; GO:0006357; GO:0006368; GO:0006461; GO:0006468; GO:0006955; GO:0008023; GO:0008607; GO:0030335; GO:0033588 0 0 0 PF04762; O95239 CHOYP_KIF4A.1.1 m.10797 sp KIF4A_HUMAN 42.457 1286 633 23 3 1242 4 1228 0 887 KIF4A_HUMAN reviewed Chromosome-associated kinesin KIF4A (Chromokinesin-A) KIF4A KIF4 Homo sapiens (Human) 1232 "anterograde axonal transport [GO:0008089]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; organelle organization [GO:0006996]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000281; GO:0003677; GO:0003777; GO:0005524; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0005871; GO:0005876; GO:0006890; GO:0006996; GO:0007018; GO:0008089; GO:0008574; GO:0016020; GO:0016363; GO:0019886; GO:0030496; GO:0051256; GO:1904115 0 0 0 PF00225; O95248 CHOYP_LOC100745865.1.1 m.24024 sp MTMR5_HUMAN 47.701 696 308 18 1 685 603 1253 0 598 MTMR5_HUMAN reviewed Myotubularin-related protein 5 (SET-binding factor 1) (Sbf1) SBF1 MTMR5 Homo sapiens (Human) 1867 protein dephosphorylation [GO:0006470]; spermatogenesis [GO:0007283] GO:0005634; GO:0006470; GO:0007283; GO:0008138; GO:0016021; GO:0017112; GO:0019208 0 0 0 PF02141;PF02893;PF06602;PF00169;PF12335;PF03456; O95251 CHOYP_KAT7.1.1 m.51122 sp KAT7_HUMAN 51.805 637 249 12 1 609 1 607 0 593 KAT7_HUMAN reviewed "Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)" KAT7 HBO1 HBOa MYST2 Homo sapiens (Human) 611 "DNA replication [GO:0006260]; histone H3 acetylation [GO:0043966]; histone H4-K12 acetylation [GO:0043983]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; positive regulation of protein localization to nucleus [GO:1900182]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003700; GO:0004402; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006351; GO:0006355; GO:0008270; GO:0043966; GO:0043981; GO:0043982; GO:0043983; GO:1900182 0 0 0 PF01853;PF01530; O95263 CHOYP_PDE8B.1.1 m.20358 sp PDE8B_HUMAN 54.075 773 322 6 21 777 114 869 0 856 PDE8B_HUMAN reviewed "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)" PDE8B PIG22 Homo sapiens (Human) 885 cAMP catabolic process [GO:0006198]; cyclic nucleotide metabolic process [GO:0009187]; negative regulation of insulin secretion [GO:0046676]; signal transduction [GO:0007165] GO:0004114; GO:0004115; GO:0005829; GO:0006198; GO:0007165; GO:0009187; GO:0046676; GO:0046872 "PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." 0 0 PF13426;PF08629;PF00233; O95271 CHOYP_TNKS1.1.5 m.6850 sp TNKS1_HUMAN 75.087 1152 267 9 25 1164 184 1327 0 1785 TNKS1_HUMAN reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) 1327 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000242; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007052; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0031965; GO:0032210; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; O95271 CHOYP_TNKS1.2.5 m.18806 sp TNKS1_HUMAN 77.008 361 81 1 40 398 300 660 0 575 TNKS1_HUMAN reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) 1327 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000242; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007052; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0031965; GO:0032210; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; O95394 CHOYP_BRAFLDRAFT_285738.1.1 m.21025 sp AGM1_HUMAN 55.871 528 223 5 33 559 21 539 0 590 AGM1_HUMAN reviewed Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) PGM3 AGM1 Homo sapiens (Human) 542 glucosamine metabolic process [GO:0006041]; glucose 1-phosphate metabolic process [GO:0019255]; hemopoiesis [GO:0030097]; protein N-linked glycosylation [GO:0006487]; protein O-linked glycosylation [GO:0006493]; spermatogenesis [GO:0007283]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0000287; GO:0004610; GO:0004614; GO:0005829; GO:0006041; GO:0006048; GO:0006487; GO:0006493; GO:0007283; GO:0019255; GO:0030097 "PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2. {ECO:0000303|PubMed:24589341, ECO:0000303|PubMed:24698316, ECO:0000303|PubMed:24931394}." 0 cd03086; PF02878;PF00408; O95405 CHOYP_LOC575625.1.2 m.50064 sp ZFYV9_HUMAN 48.103 738 307 11 780 1445 689 1422 0 697 ZFYV9_HUMAN reviewed Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) ZFYVE9 MADHIP SARA SMADIP Homo sapiens (Human) 1425 endocytosis [GO:0006897]; SMAD protein complex assembly [GO:0007183]; SMAD protein import into nucleus [GO:0007184]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005545; GO:0005769; GO:0006897; GO:0007179; GO:0007183; GO:0007184; GO:0008236; GO:0031901; GO:0046872 0 0 0 PF11979;PF01363;PF11409; O95405 CHOYP_LOC575625.2.2 m.52201 sp ZFYV9_HUMAN 51.696 737 312 8 780 1475 689 1422 0 786 ZFYV9_HUMAN reviewed Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) ZFYVE9 MADHIP SARA SMADIP Homo sapiens (Human) 1425 endocytosis [GO:0006897]; SMAD protein complex assembly [GO:0007183]; SMAD protein import into nucleus [GO:0007184]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005545; GO:0005769; GO:0006897; GO:0007179; GO:0007183; GO:0007184; GO:0008236; GO:0031901; GO:0046872 0 0 0 PF11979;PF01363;PF11409; O95425 CHOYP_LOC578781.1.5 m.2353 sp SVIL_HUMAN 34.843 1656 885 49 2773 4315 640 2214 0 849 SVIL_HUMAN reviewed Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) 2214 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] GO:0002102; GO:0005634; GO:0005737; GO:0005886; GO:0005925; GO:0007010; GO:0007519; GO:0015629; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0043034; GO:0051015; GO:0071437 0 0 0 PF00626;PF02209; O95425 CHOYP_LOC578781.2.5 m.8827 sp SVIL_HUMAN 35.301 1660 888 49 1617 3175 640 2214 0 875 SVIL_HUMAN reviewed Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) 2214 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] GO:0002102; GO:0005634; GO:0005737; GO:0005886; GO:0005925; GO:0007010; GO:0007519; GO:0015629; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0043034; GO:0051015; GO:0071437 0 0 0 PF00626;PF02209; O95425 CHOYP_LOC578781.3.5 m.13926 sp SVIL_HUMAN 35.283 1658 891 50 2527 4085 640 2214 0 876 SVIL_HUMAN reviewed Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) 2214 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] GO:0002102; GO:0005634; GO:0005737; GO:0005886; GO:0005925; GO:0007010; GO:0007519; GO:0015629; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0043034; GO:0051015; GO:0071437 0 0 0 PF00626;PF02209; O95425 CHOYP_LOC578781.5.5 m.52615 sp SVIL_HUMAN 35.458 1647 871 48 2967 4493 640 2214 0 881 SVIL_HUMAN reviewed Supervillin (Archvillin) (p205/p250) SVIL Homo sapiens (Human) 2214 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] GO:0002102; GO:0005634; GO:0005737; GO:0005886; GO:0005925; GO:0007010; GO:0007519; GO:0015629; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0043034; GO:0051015; GO:0071437 0 0 0 PF00626;PF02209; O95461 CHOYP_LARGE.1.2 m.16148 sp LARGE_HUMAN 59.882 678 249 5 58 712 76 753 0 868 LARGE_HUMAN reviewed "Glycosyltransferase-like protein LARGE1 (EC 2.4.-.-) (Acetylglucosaminyltransferase-like 1A) [Includes: Xylosyltransferase LARGE (EC 2.4.2.-); Beta-1,3-glucuronyltransferase LARGE (EC 2.4.1.-)]" LARGE KIAA0609 LARGE1 Homo sapiens (Human) 756 glycoprotein biosynthetic process [GO:0009101]; glycosphingolipid biosynthetic process [GO:0006688]; muscle cell cellular homeostasis [GO:0046716]; N-acetylglucosamine metabolic process [GO:0006044]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; skeletal muscle organ development [GO:0060538]; skeletal muscle tissue regeneration [GO:0043403] GO:0000139; GO:0005794; GO:0006044; GO:0006486; GO:0006493; GO:0006688; GO:0008375; GO:0009101; GO:0015020; GO:0016757; GO:0030145; GO:0030173; GO:0035252; GO:0035269; GO:0042285; GO:0043403; GO:0046716; GO:0060538 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:25279697, ECO:0000269|PubMed:25279699}." 0 0 PF01501; O95479 CHOYP_G6PE.1.1 m.33399 sp G6PE_HUMAN 40.025 797 439 17 19 791 8 789 0 553 G6PE_HUMAN reviewed GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] H6PD GDH Homo sapiens (Human) 791 glucose metabolic process [GO:0006006]; pentose-phosphate shunt [GO:0006098] GO:0004345; GO:0005788; GO:0006006; GO:0006098; GO:0017057; GO:0047936; GO:0050661 0 0 cd01400; PF02781;PF00479;PF01182; O95487 CHOYP_SC24B.1.2 m.95 sp SC24B_HUMAN 58.08 823 323 7 548 1356 452 1266 0 991 SC24B_HUMAN reviewed Protein transport protein Sec24B (SEC24-related protein B) SEC24B Homo sapiens (Human) 1268 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; aorta morphogenesis [GO:0035909]; auditory receptor cell stereocilium organization [GO:0060088]; cochlear nucleus development [GO:0021747]; COPII vesicle coating [GO:0048208]; coronary artery morphogenesis [GO:0060982]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lung lobe morphogenesis [GO:0060463]; neural tube closure [GO:0001843]; outflow tract morphogenesis [GO:0003151]; pulmonary artery morphogenesis [GO:0061156]; regulation of cargo loading into COPII-coated vesicle [GO:1901301]; regulation of establishment of planar polarity involved in neural tube closure [GO:0090178]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0001843; GO:0002474; GO:0003151; GO:0005215; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0008270; GO:0012507; GO:0016020; GO:0016192; GO:0019886; GO:0021747; GO:0030127; GO:0035909; GO:0048208; GO:0048471; GO:0060088; GO:0060463; GO:0060982; GO:0061156; GO:0090178; GO:1901301 0 0 0 PF00626;PF08033;PF04815;PF04811;PF04810; O95487 CHOYP_SC24B.2.2 m.54667 sp SC24B_HUMAN 57.959 823 324 7 579 1387 452 1266 0 989 SC24B_HUMAN reviewed Protein transport protein Sec24B (SEC24-related protein B) SEC24B Homo sapiens (Human) 1268 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; aorta morphogenesis [GO:0035909]; auditory receptor cell stereocilium organization [GO:0060088]; cochlear nucleus development [GO:0021747]; COPII vesicle coating [GO:0048208]; coronary artery morphogenesis [GO:0060982]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lung lobe morphogenesis [GO:0060463]; neural tube closure [GO:0001843]; outflow tract morphogenesis [GO:0003151]; pulmonary artery morphogenesis [GO:0061156]; regulation of cargo loading into COPII-coated vesicle [GO:1901301]; regulation of establishment of planar polarity involved in neural tube closure [GO:0090178]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0001843; GO:0002474; GO:0003151; GO:0005215; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0008270; GO:0012507; GO:0016020; GO:0016192; GO:0019886; GO:0021747; GO:0030127; GO:0035909; GO:0048208; GO:0048471; GO:0060088; GO:0060463; GO:0060982; GO:0061156; GO:0090178; GO:1901301 0 0 0 PF00626;PF08033;PF04815;PF04811;PF04810; O95714 CHOYP_HERC2.1.1 m.65153 sp HERC2_HUMAN 58.06 3865 1440 42 8 3832 1081 4804 0 4412 HERC2_HUMAN reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; intracellular protein transport [GO:0006886]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005743; GO:0005814; GO:0006303; GO:0006886; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016925; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; O95714 CHOYP_HERC2.1.1 m.65154 sp HERC2_HUMAN 52.658 997 427 10 9 993 8 971 0 965 HERC2_HUMAN reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; intracellular protein transport [GO:0006886]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005743; GO:0005814; GO:0006303; GO:0006886; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016925; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; O95757 CHOYP_HS74L.1.1 m.24610 sp HS74L_HUMAN 51.001 849 390 10 1 833 1 839 0 850 HS74L_HUMAN reviewed Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) HSPA4L APG1 OSP94 Homo sapiens (Human) 839 protein folding [GO:0006457]; response to unfolded protein [GO:0006986] GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006457; GO:0006986 0 0 0 PF00012; O95758 CHOYP_LOC100745429.1.1 m.27818 sp PTBP3_HUMAN 54.48 558 215 11 61 593 9 552 0 565 PTBP3_HUMAN reviewed Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) PTBP3 ROD1 Homo sapiens (Human) 552 anatomical structure morphogenesis [GO:0009653]; erythrocyte maturation [GO:0043249]; mRNA processing [GO:0006397]; negative regulation of RNA splicing [GO:0033119]; regulation of cell differentiation [GO:0045595]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005634; GO:0006397; GO:0008380; GO:0009653; GO:0033119; GO:0043249; GO:0044822; GO:0045595 0 0 0 PF00076; O95835 CHOYP_LATS2.1.1 m.716 sp LATS1_HUMAN 62.923 561 185 9 626 1175 543 1091 0 697 LATS1_HUMAN reviewed Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) LATS1 WARTS Homo sapiens (Human) 1130 cell division [GO:0051301]; cytoplasmic sequestering of protein [GO:0051220]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; hippo signaling [GO:0035329]; hormone-mediated signaling pathway [GO:0009755]; inner cell mass cell fate commitment [GO:0001827]; inner cell mass cellular morphogenesis [GO:0001828]; keratinocyte differentiation [GO:0030216]; mitotic nuclear division [GO:0007067]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; positive regulation of apoptotic process [GO:0043065]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; protein phosphorylation [GO:0006468]; regulation of actin filament polymerization [GO:0030833]; regulation of organ growth [GO:0046620]; regulation of protein complex assembly [GO:0043254]; sister chromatid segregation [GO:0000819] GO:0000082; GO:0000086; GO:0000287; GO:0000819; GO:0000922; GO:0001827; GO:0001828; GO:0004674; GO:0005524; GO:0005815; GO:0005829; GO:0006468; GO:0007067; GO:0009755; GO:0019901; GO:0030216; GO:0030833; GO:0033138; GO:0035329; GO:0043065; GO:0043254; GO:0045736; GO:0046620; GO:0051220; GO:0051301; GO:0090090 0 0 0 PF00069;PF00627; O95876 CHOYP_FRITZ.1.1 m.55127 sp FRITZ_HUMAN 42.914 748 380 12 1 736 34 746 0 584 FRITZ_HUMAN reviewed WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein) WDPCP BBS15 C2orf86 FRITZ Homo sapiens (Human) 746 auditory receptor cell morphogenesis [GO:0002093]; camera-type eye development [GO:0043010]; cardiovascular system development [GO:0072358]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; digestive system development [GO:0055123]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; establishment of protein localization [GO:0045184]; glomerular visceral epithelial cell migration [GO:0090521]; kidney development [GO:0001822]; palate development [GO:0060021]; regulation of embryonic cell shape [GO:0016476]; regulation of establishment of cell polarity [GO:2000114]; regulation of fibroblast migration [GO:0010762]; regulation of focal adhesion assembly [GO:0051893]; regulation of protein localization [GO:0032880]; regulation of ruffle assembly [GO:1900027]; respiratory system development [GO:0060541]; septin cytoskeleton organization [GO:0032185]; smoothened signaling pathway [GO:0007224] GO:0001736; GO:0001822; GO:0002093; GO:0005737; GO:0005886; GO:0005930; GO:0007224; GO:0010762; GO:0016476; GO:0032185; GO:0032880; GO:0042384; GO:0042733; GO:0043010; GO:0045184; GO:0051893; GO:0055123; GO:0060021; GO:0060271; GO:0060541; GO:0072358; GO:0090521; GO:0097541; GO:1900027; GO:2000114 0 0 0 PF11768; O95922 CHOYP_BRAFLDRAFT_281016.1.1 m.62277 sp TTLL1_HUMAN 69.194 422 124 2 2 418 3 423 0 637 TTLL1_HUMAN reviewed Probable tubulin polyglutamylase TTLL1 (EC 6.-.-.-) (Tubulin polyglutamylase complex subunit 3) (PGs3) (Tubulin--tyrosine ligase-like protein 1) TTLL1 C22orf7 Homo sapiens (Human) 423 axoneme assembly [GO:0035082]; epithelial cilium movement [GO:0003351]; protein polyglutamylation [GO:0018095] GO:0003351; GO:0005524; GO:0005737; GO:0005874; GO:0018095; GO:0035082; GO:0070740 0 0 0 PF03133; O95980 CHOYP_RECK.1.1 m.39764 sp RECK_HUMAN 39.247 930 523 21 21 928 36 945 0 645 RECK_HUMAN reviewed Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein) RECK ST15 Homo sapiens (Human) 971 blood vessel maturation [GO:0001955]; embryo implantation [GO:0007566]; embryonic forelimb morphogenesis [GO:0035115]; extracellular matrix organization [GO:0030198]; negative regulation of cell migration [GO:0030336]; negative regulation of metalloendopeptidase activity [GO:1904684] GO:0001955; GO:0004866; GO:0004867; GO:0005886; GO:0007566; GO:0008191; GO:0016020; GO:0030198; GO:0030336; GO:0031225; GO:0035115; GO:1904684 0 0 0 PF07648; O95985 CHOYP_TOP3B.1.1 m.1654 sp TOP3B_HUMAN 70.293 818 238 3 1 815 1 816 0 1214 TOP3B_HUMAN reviewed DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta-1) TOP3B TOP3B1 Homo sapiens (Human) 862 chromosome segregation [GO:0007059]; DNA topological change [GO:0006265] GO:0000793; GO:0003677; GO:0003916; GO:0003917; GO:0005634; GO:0005829; GO:0006265; GO:0007059; GO:0044822 0 0 cd00186; PF01131;PF01751; O95995 CHOYP_BRAFLDRAFT_263599.1.1 m.59010 sp GAS8_HUMAN 70.753 465 135 1 22 486 15 478 0 653 GAS8_HUMAN reviewed Growth arrest-specific protein 8 (GAS-8) (Growth arrest-specific protein 11) (GAS-11) GAS8 GAS11 Homo sapiens (Human) 478 cellular protein localization [GO:0034613]; negative regulation of cell proliferation [GO:0008285]; regulation of microtubule binding [GO:1904526]; sperm motility [GO:0030317] GO:0005794; GO:0005874; GO:0005929; GO:0005930; GO:0008017; GO:0008285; GO:0017137; GO:0030317; GO:0031514; GO:0034613; GO:0036064; GO:1904526 0 0 0 PF13851; O96064 CHOYP_EGFR.1.3 m.30286 sp MYSP_MYTGA 77.278 823 184 2 3 824 7 827 0 1197 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; O96064 CHOYP_MYSP.5.9 m.28124 sp MYSP_MYTGA 76.996 839 190 2 3 840 7 843 0 1213 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; O96064 CHOYP_MYSP.6.9 m.40720 sp MYSP_MYTGA 81.378 392 73 0 18 409 179 570 0 588 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; O96064 CHOYP_MYSP.8.9 m.44813 sp MYSP_MYTGA 79.36 688 142 0 12 699 177 864 0 998 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; O96064 CHOYP_MYSP.9.9 m.49629 sp MYSP_MYTGA 79.242 554 115 0 1 554 311 864 0 788 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; O97125 CHOYP_HSP68.1.1 m.49558 sp HSP68_DROME 63.262 607 221 1 27 631 1 607 0 805 HSP68_DROME reviewed Heat shock protein 68 Hsp68 CG5436 Drosophila melanogaster (Fruit fly) 635 determination of adult lifespan [GO:0008340]; neurogenesis [GO:0022008]; response to methotrexate [GO:0031427]; response to starvation [GO:0042594] GO:0005524; GO:0005811; GO:0005875; GO:0008340; GO:0022008; GO:0031427; GO:0042594 0 0 0 PF00012; O97593 CHOYP_LOC100374527.1.1 m.55214 sp SMC1A_BOVIN 62.631 1239 447 5 3 1238 2 1227 0 1503 SMC1A_BOVIN reviewed Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1A) SMC1A SMC1 SMC1L1 Bos taurus (Bovine) 1233 cell division [GO:0051301]; DNA repair [GO:0006281]; meiotic nuclear division [GO:0007126]; mitotic cell cycle checkpoint [GO:0007093]; mitotic sister chromatid cohesion [GO:0007064]; response to radiation [GO:0009314]; signal transduction in response to DNA damage [GO:0042770] GO:0000776; GO:0003682; GO:0005524; GO:0005634; GO:0006281; GO:0007064; GO:0007093; GO:0007126; GO:0008280; GO:0009314; GO:0030893; GO:0042770; GO:0051301 0 0 0 PF06470;PF02463; O97902 CHOYP_BRAFLDRAFT_199108.1.2 m.24078 sp ASAP1_BOVIN 45.65 839 397 16 1 826 21 813 0 672 ASAP1_BOVIN reviewed "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)" ASAP1 DDEF1 Bos taurus (Bovine) 1129 cilium morphogenesis [GO:0060271] GO:0005096; GO:0005737; GO:0016020; GO:0046872; GO:0060271 0 0 0 PF12796;PF01412;PF00169;PF00018; O97902 CHOYP_BRAFLDRAFT_199108.2.2 m.33138 sp ASAP1_BOVIN 43.931 865 404 15 1 856 21 813 0 663 ASAP1_BOVIN reviewed "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)" ASAP1 DDEF1 Bos taurus (Bovine) 1129 cilium morphogenesis [GO:0060271] GO:0005096; GO:0005737; GO:0016020; GO:0046872; GO:0060271 0 0 0 PF12796;PF01412;PF00169;PF00018; P00367 CHOYP_DHE4.1.1 m.48536 sp DHE3_HUMAN 74.419 516 126 3 29 542 47 558 0 811 DHE3_HUMAN reviewed "Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)" GLUD1 GLUD Homo sapiens (Human) 558 cellular amino acid biosynthetic process [GO:0008652]; glutamate biosynthetic process [GO:0006537]; glutamate catabolic process [GO:0006538]; glutamine metabolic process [GO:0006541]; positive regulation of insulin secretion [GO:0032024]; substantia nigra development [GO:0021762]; tricarboxylic acid metabolic process [GO:0072350] GO:0004352; GO:0004353; GO:0005524; GO:0005525; GO:0005737; GO:0005739; GO:0005759; GO:0006537; GO:0006538; GO:0006541; GO:0008652; GO:0021762; GO:0032024; GO:0042802; GO:0043531; GO:0070403; GO:0070728; GO:0072350 0 0 0 PF00208;PF02812; P00432 CHOYP_CAT.1.1 m.57038 sp CATA_BOVIN 68.8 500 154 1 4 501 5 504 0 743 CATA_BOVIN reviewed Catalase (EC 1.11.1.6) CAT Bos taurus (Bovine) 527 aerobic respiration [GO:0009060]; cholesterol metabolic process [GO:0008203]; hemoglobin metabolic process [GO:0020027]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; osteoblast differentiation [GO:0001649]; oxidation-reduction process [GO:0055114]; positive regulation of cell division [GO:0051781]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; protein homotetramerization [GO:0051289]; response to hydrogen peroxide [GO:0042542]; triglyceride metabolic process [GO:0006641]; UV protection [GO:0009650] GO:0001649; GO:0004046; GO:0004096; GO:0005739; GO:0005777; GO:0005778; GO:0005925; GO:0006641; GO:0008203; GO:0009060; GO:0009650; GO:0014068; GO:0019899; GO:0020027; GO:0020037; GO:0032088; GO:0042542; GO:0042744; GO:0043066; GO:0046872; GO:0050661; GO:0051092; GO:0051289; GO:0051781; GO:0055114; GO:0070062 0 0 0 PF00199;PF06628; P00516 CHOYP_KGP1.1.1 m.38628 sp KGP1_BOVIN 68.546 674 202 6 48 714 1 671 0 959 KGP1_BOVIN reviewed cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) PRKG1 PRKG1B PRKGR1A PRKGR1B Bos taurus (Bovine) 671 negative regulation of platelet aggregation [GO:0090331]; regulation of GTPase activity [GO:0043087] GO:0004692; GO:0005246; GO:0005524; GO:0005737; GO:0005829; GO:0030553; GO:0043087; GO:0090331 0 0 0 PF00027;PF16808;PF00069; P00522 CHOYP_ABL1.1.1 m.55647 sp ABL_DROME 75.693 469 109 3 60 524 172 639 0 797 ABL_DROME reviewed Tyrosine-protein kinase Abl (EC 2.7.10.2) (D-ash) (Protein abelson) Abl ABL-1 Dash CG4032 Drosophila melanogaster (Fruit fly) 1620 "axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; branchiomotor neuron axon guidance [GO:0021785]; central nervous system development [GO:0007417]; chemical synaptic transmission [GO:0007268]; compound eye development [GO:0048749]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; dendrite morphogenesis [GO:0048813]; dorsal closure [GO:0007391]; epithelial cell morphogenesis [GO:0003382]; innate immune response [GO:0045087]; learning or memory [GO:0007611]; morphogenesis of an epithelium [GO:0002009]; motor neuron axon guidance [GO:0008045]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; neuron migration [GO:0001764]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; photoreceptor cell axon guidance [GO:0072499]; planar cell polarity pathway involved in axis elongation [GO:0003402]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of protein export from nucleus [GO:0046827]; protein phosphorylation [GO:0006468]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of cell proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of glucose metabolic process [GO:0010906]; regulation of protein localization [GO:0032880]; regulation of protein stability [GO:0031647]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ventral cord development [GO:0007419]; ventral furrow formation [GO:0007370]" GO:0001764; GO:0002009; GO:0003382; GO:0003402; GO:0004713; GO:0004715; GO:0005524; GO:0005737; GO:0005829; GO:0005911; GO:0005912; GO:0005927; GO:0005938; GO:0006468; GO:0007169; GO:0007268; GO:0007303; GO:0007370; GO:0007391; GO:0007409; GO:0007411; GO:0007417; GO:0007419; GO:0007611; GO:0008045; GO:0008064; GO:0008360; GO:0010592; GO:0010906; GO:0010977; GO:0016199; GO:0018108; GO:0019897; GO:0021785; GO:0030424; GO:0031234; GO:0031647; GO:0032880; GO:0038083; GO:0042127; GO:0045087; GO:0045179; GO:0045886; GO:0046827; GO:0048749; GO:0048813; GO:0072499 0 0 0 PF08919;PF07714;PF00017;PF00018; P00523 CHOYP_FYNA.1.1 m.63901 sp SRC_CHICK 58.193 476 189 5 29 503 66 532 0 575 SRC_CHICK reviewed Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC Gallus gallus (Chicken) 533 angiotensin-activated signaling pathway involved in heart process [GO:0086098]; bone resorption [GO:0045453]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell migration [GO:0016477]; cellular response to fluid shear stress [GO:0071498]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to reactive oxygen species [GO:0034614]; central nervous system development [GO:0007417]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular signal transduction [GO:0035556]; negative regulation of anoikis [GO:2000811]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; oogenesis [GO:0048477]; osteoclast development [GO:0036035]; peptidyl-tyrosine autophosphorylation [GO:0038083]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; progesterone receptor signaling pathway [GO:0050847]; protein destabilization [GO:0031648]; regulation of caveolin-mediated endocytosis [GO:2001286]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell cycle [GO:0051726]; regulation of cell projection assembly [GO:0060491]; regulation of cell proliferation [GO:0042127]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of podosome assembly [GO:0071801]; regulation of protein binding [GO:0043393]; response to interleukin-1 [GO:0070555]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065] GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0005743; GO:0005764; GO:0005770; GO:0005829; GO:0005884; GO:0005901; GO:0007049; GO:0007155; GO:0007173; GO:0007179; GO:0007229; GO:0007417; GO:0010008; GO:0010634; GO:0016477; GO:0019903; GO:0020037; GO:0022407; GO:0030520; GO:0030900; GO:0031234; GO:0031648; GO:0032211; GO:0032463; GO:0032587; GO:0033146; GO:0034446; GO:0034614; GO:0035556; GO:0036035; GO:0036120; GO:0038083; GO:0042127; GO:0043149; GO:0043154; GO:0043393; GO:0045087; GO:0045453; GO:0048008; GO:0048013; GO:0048471; GO:0048477; GO:0050847; GO:0051427; GO:0051726; GO:0051897; GO:0051902; GO:0051974; GO:0060065; GO:0060491; GO:0070062; GO:0070374; GO:0070555; GO:0070851; GO:0071498; GO:0071801; GO:0071803; GO:0071902; GO:0086098; GO:0090263; GO:2000394; GO:2000641; GO:2000811; GO:2001237; GO:2001243; GO:2001286 0 0 0 PF07714;PF00017;PF00018; P00523 CHOYP_SMUF2.1.1 m.14325 sp SRC_CHICK 57.983 476 190 5 29 503 66 532 0 575 SRC_CHICK reviewed Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) SRC Gallus gallus (Chicken) 533 angiotensin-activated signaling pathway involved in heart process [GO:0086098]; bone resorption [GO:0045453]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell migration [GO:0016477]; cellular response to fluid shear stress [GO:0071498]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to reactive oxygen species [GO:0034614]; central nervous system development [GO:0007417]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; forebrain development [GO:0030900]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular estrogen receptor signaling pathway [GO:0030520]; intracellular signal transduction [GO:0035556]; negative regulation of anoikis [GO:2000811]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; oogenesis [GO:0048477]; osteoclast development [GO:0036035]; peptidyl-tyrosine autophosphorylation [GO:0038083]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; progesterone receptor signaling pathway [GO:0050847]; protein destabilization [GO:0031648]; regulation of caveolin-mediated endocytosis [GO:2001286]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell cycle [GO:0051726]; regulation of cell projection assembly [GO:0060491]; regulation of cell proliferation [GO:0042127]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of podosome assembly [GO:0071801]; regulation of protein binding [GO:0043393]; response to interleukin-1 [GO:0070555]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065] GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0005743; GO:0005764; GO:0005770; GO:0005829; GO:0005884; GO:0005901; GO:0007049; GO:0007155; GO:0007173; GO:0007179; GO:0007229; GO:0007417; GO:0010008; GO:0010634; GO:0016477; GO:0019903; GO:0020037; GO:0022407; GO:0030520; GO:0030900; GO:0031234; GO:0031648; GO:0032211; GO:0032463; GO:0032587; GO:0033146; GO:0034446; GO:0034614; GO:0035556; GO:0036035; GO:0036120; GO:0038083; GO:0042127; GO:0043149; GO:0043154; GO:0043393; GO:0045087; GO:0045453; GO:0048008; GO:0048013; GO:0048471; GO:0048477; GO:0050847; GO:0051427; GO:0051726; GO:0051897; GO:0051902; GO:0051974; GO:0060065; GO:0060491; GO:0070062; GO:0070374; GO:0070555; GO:0070851; GO:0071498; GO:0071801; GO:0071803; GO:0071902; GO:0086098; GO:0090263; GO:2000394; GO:2000641; GO:2000811; GO:2001237; GO:2001243; GO:2001286 0 0 0 PF07714;PF00017;PF00018; P00727 CHOYP_AMPL.1.1 m.27061 sp AMPL_BOVIN 55.273 512 206 6 35 531 15 518 0 573 AMPL_BOVIN reviewed Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) LAP3 Bos taurus (Bovine) 519 0 GO:0004177; GO:0005654; GO:0005739; GO:0005925; GO:0008233; GO:0008235; GO:0030145; GO:0070062 0 0 cd00433; PF00883;PF02789; P02466 CHOYP_CO2A1.1.1 m.62996 sp CO1A2_RAT 44.968 1401 709 14 67 1439 6 1372 0 647 CO1A2_RAT reviewed Collagen alpha-2(I) chain (Alpha-2 type I collagen) Col1a2 Rattus norvegicus (Rat) 1372 cellular response to organic substance [GO:0071310]; cellular response to retinoic acid [GO:0071300]; cellular response to thyroid hormone stimulus [GO:0097067]; extracellular matrix organization [GO:0030198]; response to norepinephrine [GO:0071873] GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0030198; GO:0046872; GO:0071300; GO:0071310; GO:0071873; GO:0097067 0 0 0 PF01410;PF01391; P02552 CHOYP_LOC584364.1.2 m.38131 sp TBA1_CHICK 98.394 249 4 0 1 249 164 412 0 519 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P02554 CHOYP_TBB.2.7 m.37919 sp TBB_PIG 88.345 429 50 0 1 429 1 429 0 800 TBB_PIG reviewed Tubulin beta chain (Beta-tubulin) 0 Sus scrofa (Pig) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P02578 CHOYP_ACT1.4.7 m.29125 sp ACT1_ACACA 96.783 373 12 0 127 499 3 375 0 764 ACT1_ACACA reviewed Actin-1 0 Acanthamoeba castellanii (Amoeba) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P02640 CHOYP_LOC100369378.1.1 m.5391 sp VILI_CHICK 44.696 839 424 14 10 832 12 826 0 686 VILI_CHICK reviewed Villin-1 VIL1 VIL Gallus gallus (Chicken) 826 actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell migration [GO:0010634]; regulation of actin nucleation [GO:0051125]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of wound healing [GO:0061041]; response to bacterium [GO:0009617] GO:0001726; GO:0005509; GO:0005546; GO:0005737; GO:0005902; GO:0007173; GO:0008360; GO:0009617; GO:0010634; GO:0030027; GO:0030041; GO:0030042; GO:0030175; GO:0030335; GO:0032233; GO:0032432; GO:0032433; GO:0035727; GO:0035729; GO:0042803; GO:0043027; GO:0045010; GO:0051014; GO:0051015; GO:0051125; GO:0051693; GO:0060327; GO:0061041; GO:0071364; GO:2000392 0 0 0 PF00626;PF02209; P04040 CHOYP_CATA.2.3 m.18454 sp CATA_HUMAN 75.811 339 80 1 3 339 4 342 0 542 CATA_HUMAN reviewed Catalase (EC 1.11.1.6) CAT Homo sapiens (Human) 527 aerobic respiration [GO:0009060]; aging [GO:0007568]; cellular response to growth factor stimulus [GO:0071363]; cholesterol metabolic process [GO:0008203]; hemoglobin metabolic process [GO:0020027]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; osteoblast differentiation [GO:0001649]; positive regulation of cell division [GO:0051781]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; purine nucleotide catabolic process [GO:0006195]; response to activity [GO:0014823]; response to cadmium ion [GO:0046686]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to inactivity [GO:0014854]; response to insulin [GO:0032868]; response to L-ascorbic acid [GO:0033591]; response to lead ion [GO:0010288]; response to light intensity [GO:0009642]; response to ozone [GO:0010193]; response to phenylpropanoid [GO:0080184]; response to reactive oxygen species [GO:0000302]; response to vitamin A [GO:0033189]; response to vitamin E [GO:0033197]; triglyceride metabolic process [GO:0006641]; ureteric bud development [GO:0001657]; UV protection [GO:0009650] GO:0000302; GO:0001649; GO:0001657; GO:0001666; GO:0004046; GO:0004096; GO:0005102; GO:0005615; GO:0005739; GO:0005758; GO:0005764; GO:0005777; GO:0005778; GO:0005782; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0005925; GO:0006195; GO:0006641; GO:0007568; GO:0008203; GO:0009060; GO:0009642; GO:0009650; GO:0010193; GO:0010288; GO:0014068; GO:0014823; GO:0014854; GO:0016020; GO:0016209; GO:0016684; GO:0019899; GO:0020027; GO:0020037; GO:0032088; GO:0032355; GO:0032868; GO:0033189; GO:0033197; GO:0033591; GO:0042493; GO:0042542; GO:0042744; GO:0042803; GO:0043066; GO:0043231; GO:0045471; GO:0046686; GO:0046872; GO:0050661; GO:0051092; GO:0051262; GO:0051289; GO:0051781; GO:0055093; GO:0070062; GO:0070542; GO:0071363; GO:0080184 0 0 0 PF00199;PF06628; P04052 CHOYP_RPB1.1.1 m.36612 sp RPB1_DROME 71.489 1894 446 16 1 1814 1 1880 0 2759 RPB1_DROME reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) RpII215 CG1554 Drosophila melanogaster (Fruit fly) 1887 mitotic G2 DNA damage checkpoint [GO:0007095]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0005665; GO:0005700; GO:0005703; GO:0006366; GO:0007095; GO:0046872 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990; P04785 CHOYP_PDIA1.1.1 m.5297 sp PDIA1_RAT 61.475 488 178 3 18 495 22 509 0 617 PDIA1_RAT reviewed Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) P4hb Pdia1 Rattus norvegicus (Rat) 509 cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of viral entry into host cell [GO:0046598]; protein folding [GO:0006457]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0004656; GO:0005783; GO:0005788; GO:0005793; GO:0005925; GO:0006457; GO:0009897; GO:0016222; GO:0018401; GO:0019899; GO:0034663; GO:0034976; GO:0042470; GO:0044822; GO:0045454; GO:0046598; GO:0046982; GO:0070062; GO:0071456; GO:1902175 0 0 0 PF00085; P04809 CHOYP_HS90A.1.3 m.7724 sp HSP83_DROPS 80.184 434 84 1 18 451 269 700 0 735 HSP83_DROPS reviewed Heat shock protein 83 (HSP 82) Hsp83 Hsp82 GA11622 Drosophila pseudoobscura pseudoobscura (Fruit fly) 717 protein folding [GO:0006457]; response to stress [GO:0006950] GO:0005524; GO:0005737; GO:0006457; GO:0006950 0 0 0 PF02518;PF00183; P05031 CHOYP_DDC.1.1 m.10290 sp DDC_DROME 57.203 472 201 1 1 472 36 506 0 590 DDC_DROME reviewed Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC) Ddc CG10697 Drosophila melanogaster (Fruit fly) 510 adult chitin-containing cuticle pigmentation [GO:0048085]; anesthesia-resistant memory [GO:0007615]; cellular amino acid metabolic process [GO:0006520]; courtship behavior [GO:0007619]; developmental pigmentation [GO:0048066]; dopamine biosynthetic process from tyrosine [GO:0006585]; eclosion rhythm [GO:0008062]; growth [GO:0040007]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; regulation of adult chitin-containing cuticle pigmentation [GO:0048082]; response to wounding [GO:0009611]; serotonin biosynthetic process from tryptophan [GO:0006587]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052]; wing disc development [GO:0035220] GO:0004058; GO:0006520; GO:0006585; GO:0006587; GO:0007611; GO:0007615; GO:0007616; GO:0007619; GO:0008062; GO:0009611; GO:0030170; GO:0035220; GO:0040007; GO:0040040; GO:0043052; GO:0048066; GO:0048082; GO:0048085 0 0 0 PF00282; P05153 CHOYP_PCKG.1.2 m.43784 sp PCKGC_CHICK 65.422 616 210 3 127 742 10 622 0 873 PCKGC_CHICK reviewed "Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PEPCK-C) (EC 4.1.1.32)" PCK1 Gallus gallus (Chicken) 622 adult feeding behavior [GO:0008343]; aging [GO:0007568]; alanine metabolic process [GO:0006522]; aspartate metabolic process [GO:0006531]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to ethanol [GO:0071361]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to retinoic acid [GO:0071300]; cellular response to tumor necrosis factor [GO:0071356]; developmental growth [GO:0048589]; digestion [GO:0007586]; eggshell formation [GO:0030703]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic organ morphogenesis [GO:0048562]; gluconeogenesis [GO:0006094]; glutamate metabolic process [GO:0006536]; glutamine metabolic process [GO:0006541]; glycerol catabolic process [GO:0019563]; glycine metabolic process [GO:0006544]; hepatocyte differentiation [GO:0070365]; intestinal absorption [GO:0050892]; kidney interstitial fibroblast differentiation [GO:0072071]; lactate metabolic process [GO:0006089]; lipid catabolic process [GO:0016042]; malate transport [GO:0015743]; NADH regeneration [GO:0006735]; negative regulation of carbohydrate metabolic process [GO:0045912]; oviposition [GO:0018991]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of carbohydrate metabolic process [GO:0045913]; positive regulation of gluconeogenesis [GO:0045722]; proline metabolic process [GO:0006560]; propionate catabolic process [GO:0019543]; pyruvate metabolic process [GO:0006090]; regulation of feeding behavior [GO:0060259]; regulation of gluconeogenesis [GO:0006111]; regulation of transcription by glucose [GO:0046015]; response to cAMP [GO:0051591]; response to cycloheximide [GO:0046898]; response to glucocorticoid [GO:0051384]; response to interleukin-6 [GO:0070741]; response to lipid [GO:0033993]; response to lipopolysaccharide [GO:0032496]; response to methionine [GO:1904640]; response to starvation [GO:0042594]; serine family amino acid metabolic process [GO:0009069]; sexual reproduction [GO:0019953]; vitellogenesis [GO:0007296] GO:0003729; GO:0004613; GO:0005525; GO:0005829; GO:0006089; GO:0006090; GO:0006094; GO:0006111; GO:0006522; GO:0006531; GO:0006536; GO:0006541; GO:0006544; GO:0006560; GO:0006735; GO:0007296; GO:0007568; GO:0007586; GO:0008343; GO:0008906; GO:0009069; GO:0009792; GO:0015743; GO:0016042; GO:0018991; GO:0019157; GO:0019543; GO:0019563; GO:0019953; GO:0030145; GO:0030703; GO:0032496; GO:0032869; GO:0033993; GO:0042149; GO:0042594; GO:0043565; GO:0043950; GO:0045722; GO:0045912; GO:0045913; GO:0046015; GO:0046898; GO:0047134; GO:0048562; GO:0048589; GO:0050692; GO:0050892; GO:0051379; GO:0051384; GO:0051591; GO:0060259; GO:0070365; GO:0070741; GO:0071300; GO:0071320; GO:0071332; GO:0071333; GO:0071347; GO:0071356; GO:0071361; GO:0071374; GO:0071377; GO:0071456; GO:0071549; GO:0072071; GO:1904640 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. 0 0 PF00821; P05166 CHOYP_PCCB.1.2 m.3058 sp PCCB_HUMAN 80.08 497 96 2 2 495 43 539 0 843 PCCB_HUMAN reviewed "Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)" PCCB Homo sapiens (Human) 539 biotin metabolic process [GO:0006768]; short-chain fatty acid catabolic process [GO:0019626] GO:0004658; GO:0005524; GO:0005739; GO:0005759; GO:0005829; GO:0006768; GO:0019626 PATHWAY: Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. 0 0 PF01039; P05166 CHOYP_PCCB.2.2 m.62988 sp PCCB_HUMAN 75.547 548 117 5 9 553 6 539 0 852 PCCB_HUMAN reviewed "Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)" PCCB Homo sapiens (Human) 539 biotin metabolic process [GO:0006768]; short-chain fatty acid catabolic process [GO:0019626] GO:0004658; GO:0005524; GO:0005739; GO:0005759; GO:0005829; GO:0006768; GO:0019626 PATHWAY: Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. 0 0 PF01039; P05370 CHOYP_G6PD.1.2 m.38380 sp G6PD_RAT 68.487 476 140 5 62 530 9 481 0 692 G6PD_RAT reviewed Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) G6pdx G6pd Rattus norvegicus (Rat) 515 "cellular response to oxidative stress [GO:0034599]; cholesterol biosynthetic process [GO:0006695]; erythrocyte maturation [GO:0043249]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glutathione metabolic process [GO:0006749]; NADPH regeneration [GO:0006740]; NADP metabolic process [GO:0006739]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of protein glutathionylation [GO:0010734]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; regulation of neuron apoptotic process [GO:0043523]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to iron(III) ion [GO:0010041]; response to organic cyclic compound [GO:0014070]; ribose phosphate biosynthetic process [GO:0046390]; substantia nigra development [GO:0021762]" GO:0004345; GO:0005536; GO:0005634; GO:0005813; GO:0005829; GO:0006006; GO:0006098; GO:0006695; GO:0006739; GO:0006740; GO:0006749; GO:0009051; GO:0009898; GO:0010041; GO:0010734; GO:0014070; GO:0019322; GO:0021762; GO:0030246; GO:0032094; GO:0034599; GO:0043231; GO:0043249; GO:0043523; GO:0045471; GO:0046390; GO:0050661; GO:0051156; GO:0061052; GO:0070062; GO:1904879; GO:2000378 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. 0 0 PF02781;PF00479; P05370 CHOYP_G6PD.2.2 m.46923 sp G6PD_RAT 68.836 507 148 5 43 542 9 512 0 745 G6PD_RAT reviewed Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) G6pdx G6pd Rattus norvegicus (Rat) 515 "cellular response to oxidative stress [GO:0034599]; cholesterol biosynthetic process [GO:0006695]; erythrocyte maturation [GO:0043249]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glutathione metabolic process [GO:0006749]; NADPH regeneration [GO:0006740]; NADP metabolic process [GO:0006739]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of protein glutathionylation [GO:0010734]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; regulation of neuron apoptotic process [GO:0043523]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to iron(III) ion [GO:0010041]; response to organic cyclic compound [GO:0014070]; ribose phosphate biosynthetic process [GO:0046390]; substantia nigra development [GO:0021762]" GO:0004345; GO:0005536; GO:0005634; GO:0005813; GO:0005829; GO:0006006; GO:0006098; GO:0006695; GO:0006739; GO:0006740; GO:0006749; GO:0009051; GO:0009898; GO:0010041; GO:0010734; GO:0014070; GO:0019322; GO:0021762; GO:0030246; GO:0032094; GO:0034599; GO:0043231; GO:0043249; GO:0043523; GO:0045471; GO:0046390; GO:0050661; GO:0051156; GO:0061052; GO:0070062; GO:1904879; GO:2000378 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. 0 0 PF02781;PF00479; P06603 CHOYP_DERE_GG14119.1.1 m.39865 sp TBA1_DROME 96.166 313 12 0 1 313 1 313 0 634 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P06603 CHOYP_DERE_GG14119.1.1 m.39866 sp TBA1_DROME 97.561 328 8 0 1 328 1 328 0 672 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P06603 CHOYP_TBA1.7.9 m.44107 sp TBA1_DROME 94.595 407 15 1 1 400 1 407 0 801 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P06795 CHOYP_MDR1A.1.1 m.47026 sp MDR1B_MOUSE 53.055 671 273 6 86 756 33 661 0 705 MDR1B_MOUSE reviewed Multidrug resistance protein 1B (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1B) (P-glycoprotein 1) (CD antigen CD243) Abcb1b Abcb1 Mdr1 Mdr1b Pgy1 Pgy1-1 Mus musculus (Mouse) 1276 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; transmembrane transport [GO:0055085]" GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005524; GO:0005739; GO:0005886; GO:0008559; GO:0016021; GO:0042626; GO:0046581; GO:0055085 0 0 0 PF00664;PF00005; P07201 CHOYP_RIR2.1.1 m.19831 sp RIR2_SPISO 73.723 411 80 5 1 410 1 384 0 615 RIR2_SPISO reviewed Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit) (p41) 0 Spisula solidissima (Atlantic surf-clam) 384 deoxyribonucleoside diphosphate metabolic process [GO:0009186]; DNA replication [GO:0006260] GO:0004748; GO:0006260; GO:0009186; GO:0046872 PATHWAY: Genetic information processing; DNA replication. 0 0 PF00268; P07207 CHOYP_LOC100366518.2.6 m.27470 sp NOTCH_DROME 37.938 999 537 27 284 1253 505 1449 0 604 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P07207 CHOYP_LOC100366518.5.6 m.43397 sp NOTCH_DROME 38.316 1318 738 19 20 1273 67 1373 0 902 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P07207 CHOYP_LOC100374755.3.3 m.11610 sp NOTCH_DROME 39.205 1408 803 30 260 1637 67 1451 0 897 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P07207 CHOYP_LOC100897243.1.1 m.14190 sp NOTCH_DROME 49.057 2173 988 36 23 2157 61 2152 0 1975 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P07686 CHOYP_LOC100708717.1.1 m.5825 sp HEXB_HUMAN 51.2 500 233 5 3 493 57 554 0 552 HEXB_HUMAN reviewed Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) 556 astrocyte cell migration [GO:0043615]; cellular calcium ion homeostasis [GO:0006874]; cellular protein metabolic process [GO:0044267]; chondroitin sulfate catabolic process [GO:0030207]; ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; hyaluronan catabolic process [GO:0030214]; keratan sulfate catabolic process [GO:0042340]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501] GO:0001501; GO:0001669; GO:0004563; GO:0006687; GO:0006689; GO:0006874; GO:0007040; GO:0007341; GO:0007605; GO:0007626; GO:0008049; GO:0008360; GO:0008375; GO:0008654; GO:0009313; GO:0016020; GO:0019915; GO:0030207; GO:0030214; GO:0042340; GO:0042552; GO:0042582; GO:0042803; GO:0043202; GO:0043615; GO:0044267; GO:0045944; GO:0046982; GO:0048477; GO:0050885; GO:0070062 0 0 0 PF00728;PF14845; P07742 CHOYP_RIR1.2.2 m.30556 sp RIR1_MOUSE 81.132 795 147 1 1 795 1 792 0 1337 RIR1_MOUSE reviewed Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) Rrm1 Mus musculus (Mouse) 792 cell proliferation in forebrain [GO:0021846]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; male gonad development [GO:0008584]; mitotic cell cycle [GO:0000278]; protein heterotetramerization [GO:0051290]; protein oligomerization [GO:0051259]; pyrimidine nucleobase metabolic process [GO:0006206]; response to ionizing radiation [GO:0010212]; retina development in camera-type eye [GO:0060041] GO:0000278; GO:0004748; GO:0005524; GO:0005635; GO:0005737; GO:0005971; GO:0006206; GO:0006260; GO:0008584; GO:0009263; GO:0010212; GO:0017076; GO:0021846; GO:0042995; GO:0043025; GO:0051259; GO:0051290; GO:0060041; GO:0070062 PATHWAY: Genetic information processing; DNA replication. 0 0 PF03477;PF02867;PF00317; P07823 CHOYP_GRP78.3.5 m.38340 sp GRP78_MESAU 73.183 619 164 2 38 655 30 647 0 947 GRP78_MESAU reviewed 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) HSPA5 GRP78 Mesocricetus auratus (Golden hamster) 654 maintenance of protein localization in endoplasmic reticulum [GO:0035437]; positive regulation of cell migration [GO:0030335] GO:0005524; GO:0005788; GO:0016887; GO:0019904; GO:0030335; GO:0035437; GO:0042470; GO:0043231 0 0 0 PF00012; P07872 CHOYP_ACOX1.1.3 m.5061 sp ACOX1_RAT 51.885 663 306 4 1 653 1 660 0 709 ACOX1_RAT reviewed "Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]" Acox1 Acox Rattus norvegicus (Rat) 661 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; prostaglandin metabolic process [GO:0006693] GO:0000062; GO:0003995; GO:0003997; GO:0005504; GO:0005777; GO:0006091; GO:0006629; GO:0006693; GO:0009055; GO:0016401; GO:0019395; GO:0033539; GO:0033540; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. 0 0 PF01756;PF02770;PF14749; P07872 CHOYP_ACOX1.2.3 m.6937 sp ACOX1_RAT 43.137 663 363 6 27 681 1 657 0 534 ACOX1_RAT reviewed "Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]" Acox1 Acox Rattus norvegicus (Rat) 661 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; prostaglandin metabolic process [GO:0006693] GO:0000062; GO:0003995; GO:0003997; GO:0005504; GO:0005777; GO:0006091; GO:0006629; GO:0006693; GO:0009055; GO:0016401; GO:0019395; GO:0033539; GO:0033540; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. 0 0 PF01756;PF02770;PF14749; P07872 CHOYP_BRAFLDRAFT_278832.1.1 m.13624 sp ACOX1_RAT 49.094 662 324 4 7 658 1 659 0 687 ACOX1_RAT reviewed "Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]" Acox1 Acox Rattus norvegicus (Rat) 661 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; prostaglandin metabolic process [GO:0006693] GO:0000062; GO:0003995; GO:0003997; GO:0005504; GO:0005777; GO:0006091; GO:0006629; GO:0006693; GO:0009055; GO:0016401; GO:0019395; GO:0033539; GO:0033540; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. 0 0 PF01756;PF02770;PF14749; P07942 CHOYP_LOC100371750.2.2 m.64949 sp LAMB1_HUMAN 43.025 1792 964 22 10 1759 9 1785 0 1479 LAMB1_HUMAN reviewed Laminin subunit beta-1 (Laminin B1 chain) (Laminin-1 subunit beta) (Laminin-10 subunit beta) (Laminin-12 subunit beta) (Laminin-2 subunit beta) (Laminin-6 subunit beta) (Laminin-8 subunit beta) LAMB1 Homo sapiens (Human) 1786 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; neuronal-glial interaction involved in cerebral cortex radial glia guided migration [GO:0021812]; neuron projection development [GO:0031175]; odontogenesis [GO:0042476]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell proliferation [GO:0050679]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0005198; GO:0005201; GO:0005576; GO:0005604; GO:0005606; GO:0005607; GO:0005615; GO:0007155; GO:0021812; GO:0030198; GO:0030335; GO:0031012; GO:0031175; GO:0034446; GO:0035987; GO:0042476; GO:0043257; GO:0043259; GO:0048471; GO:0050679; GO:0070062 0 0 0 PF00053;PF00055; P07953 CHOYP_BRAFLDRAFT_277775.1.1 m.12736 sp F261_RAT 63.636 440 157 3 13 451 33 470 0 594 F261_RAT reviewed "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" Pfkfb1 Rattus norvegicus (Rat) 471 "canonical glycolysis [GO:0061621]; carbohydrate phosphorylation [GO:0046835]; energy reserve metabolic process [GO:0006112]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]; gluconeogenesis [GO:0006094]; intracellular signal transduction [GO:0035556]; organ regeneration [GO:0031100]; positive regulation of glucokinase activity [GO:0033133]; response to cAMP [GO:0051591]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; response to insulin [GO:0032868]; response to starvation [GO:0042594]" GO:0003873; GO:0004331; GO:0005524; GO:0005829; GO:0006000; GO:0006003; GO:0006094; GO:0006112; GO:0019900; GO:0031100; GO:0032868; GO:0033133; GO:0033762; GO:0035556; GO:0042594; GO:0042802; GO:0043540; GO:0046835; GO:0051384; GO:0051591; GO:0061621; GO:0070095 0 0 cd07067; PF01591;PF00300; P08120 CHOYP_CO4A2.1.2 m.14631 sp CO4A1_DROME 42.981 1852 748 41 38 1659 5 1778 0 895 CO4A1_DROME reviewed Collagen alpha-1(IV) chain Cg25C DCg1 CG4145 Drosophila melanogaster (Fruit fly) 1779 cardiac muscle cell development [GO:0055013]; dorsal closure [GO:0007391]; intestinal epithelial structure maintenance [GO:0060729]; oviduct morphogenesis [GO:0035848]; post-embryonic digestive tract morphogenesis [GO:0048621] GO:0005201; GO:0005587; GO:0007391; GO:0035848; GO:0048621; GO:0055013; GO:0060729 0 0 0 PF01413;PF01391; P08183 CHOYP_LOC582726.1.1 m.29762 sp MDR1_HUMAN 49.17 1265 609 11 40 1295 39 1278 0 1227 MDR1_HUMAN reviewed Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) 1280 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; response to drug [GO:0042493]; stem cell proliferation [GO:0072089]; transmembrane transport [GO:0055085]; transport [GO:0006810]" GO:0000086; GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005215; GO:0005524; GO:0005886; GO:0006810; GO:0008559; GO:0009986; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0055085; GO:0070062; GO:0072089 0 0 0 PF00664;PF00005; P08183 CHOYP_MDR1.1.2 m.22971 sp MDR1_HUMAN 53.519 1151 480 9 82 1221 34 1140 0 1246 MDR1_HUMAN reviewed Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) 1280 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; response to drug [GO:0042493]; stem cell proliferation [GO:0072089]; transmembrane transport [GO:0055085]; transport [GO:0006810]" GO:0000086; GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005215; GO:0005524; GO:0005886; GO:0006810; GO:0008559; GO:0009986; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0055085; GO:0070062; GO:0072089 0 0 0 PF00664;PF00005; P08183 CHOYP_MDR1.2.2 m.26335 sp MDR1_HUMAN 57.982 902 359 5 2 892 381 1273 0 1077 MDR1_HUMAN reviewed Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) 1280 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; response to drug [GO:0042493]; stem cell proliferation [GO:0072089]; transmembrane transport [GO:0055085]; transport [GO:0006810]" GO:0000086; GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005215; GO:0005524; GO:0005886; GO:0006810; GO:0008559; GO:0009986; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0055085; GO:0070062; GO:0072089 0 0 0 PF00664;PF00005; P08183 CHOYP_MDR1B.2.2 m.41554 sp MDR1_HUMAN 43.632 848 433 6 78 921 34 840 0 702 MDR1_HUMAN reviewed Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) 1280 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; response to drug [GO:0042493]; stem cell proliferation [GO:0072089]; transmembrane transport [GO:0055085]; transport [GO:0006810]" GO:0000086; GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005215; GO:0005524; GO:0005886; GO:0006810; GO:0008559; GO:0009986; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0055085; GO:0070062; GO:0072089 0 0 0 PF00664;PF00005; P08183 CHOYP_MDR3.3.3 m.66641 sp MDR1_HUMAN 56.216 1279 515 10 82 1355 34 1272 0 1451 MDR1_HUMAN reviewed Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243) ABCB1 MDR1 PGY1 Homo sapiens (Human) 1280 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; response to drug [GO:0042493]; stem cell proliferation [GO:0072089]; transmembrane transport [GO:0055085]; transport [GO:0006810]" GO:0000086; GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005215; GO:0005524; GO:0005886; GO:0006810; GO:0008559; GO:0009986; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0055085; GO:0070062; GO:0072089 0 0 0 PF00664;PF00005; P08503 CHOYP_BRAFLDRAFT_98992.1.1 m.62815 sp ACADM_RAT 72.5 400 107 1 11 410 18 414 0 612 ACADM_RAT reviewed "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7)" Acadm Rattus norvegicus (Rat) 421 fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088]; medium-chain fatty acid catabolic process [GO:0051793]; protein homotetramerization [GO:0051289]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; response to hormone [GO:0009725]; response to nutrient [GO:0007584] GO:0000062; GO:0003995; GO:0005739; GO:0005759; GO:0006635; GO:0007584; GO:0009055; GO:0009725; GO:0016853; GO:0031966; GO:0033539; GO:0042493; GO:0042802; GO:0046688; GO:0050660; GO:0051289; GO:0051384; GO:0051793; GO:0052890; GO:0055088; GO:0070991 PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. 0 0 PF00441;PF02770;PF02771; P08510 CHOYP_LOC100533422.1.1 m.54794 sp KCNAS_DROME 75.059 421 84 3 180 584 91 506 0 658 KCNAS_DROME reviewed Potassium voltage-gated channel protein Shaker (Protein minisleep) Sh mns CG12348 Drosophila melanogaster (Fruit fly) 655 "action potential [GO:0001508]; axon extension [GO:0048675]; behavioral response to ether [GO:0048150]; courtship behavior [GO:0007619]; detection of visible light [GO:0009584]; flight behavior [GO:0007629]; larval locomotory behavior [GO:0008345]; learning or memory [GO:0007611]; mating behavior, sex discrimination [GO:0048047]; potassium ion transport [GO:0006813]; proboscis extension reflex [GO:0007637]; protein homooligomerization [GO:0051260]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of synaptic activity [GO:0060025]; sensory perception of taste [GO:0050909]; sleep [GO:0030431]" GO:0001508; GO:0005249; GO:0005251; GO:0006813; GO:0007611; GO:0007619; GO:0007629; GO:0007637; GO:0008076; GO:0008345; GO:0009584; GO:0016021; GO:0022843; GO:0030431; GO:0045187; GO:0048047; GO:0048150; GO:0048675; GO:0050909; GO:0051260; GO:0060025 0 0 0 PF02214;PF00520; P08941 CHOYP_LOC100647832.1.1 m.1679 sp ROS1_CHICK 30.712 2302 1428 62 29 2259 29 2234 0 946 ROS1_CHICK reviewed Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase) ROS1 Gallus gallus (Chicken) 2311 cell differentiation [GO:0030154]; cell growth [GO:0016049]; cell proliferation [GO:0008283]; columnar/cuboidal epithelial cell development [GO:0002066]; protein phosphorylation [GO:0006468]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of TOR signaling [GO:0032006]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0002066; GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0006468; GO:0007169; GO:0008283; GO:0016021; GO:0016049; GO:0030154; GO:0032006; GO:0070372 0 0 0 PF00041;PF07714; P09623 CHOYP_DLDH.1.1 m.31018 sp DLDH_PIG 73.077 494 127 3 12 499 15 508 0 738 DLDH_PIG reviewed "Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase)" DLD LAD Sus scrofa (Pig) 509 cell redox homeostasis [GO:0045454] GO:0004148; GO:0005759; GO:0045454; GO:0050660 0 0 0 PF07992;PF02852; P09848 CHOYP_LOC587972.1.2 m.3283 sp LPH_HUMAN 47.445 959 470 10 22 962 898 1840 0 909 LPH_HUMAN reviewed Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] LCT LPH Homo sapiens (Human) 1927 carbohydrate metabolic process [GO:0005975]; glycosyl compound metabolic process [GO:1901657]; polysaccharide digestion [GO:0044245]; response to drug [GO:0042493]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]; response to nickel cation [GO:0010045]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to sucrose [GO:0009744] GO:0000016; GO:0001666; GO:0005886; GO:0005887; GO:0005903; GO:0005975; GO:0007584; GO:0008422; GO:0009725; GO:0009744; GO:0010040; GO:0010045; GO:0010288; GO:0016020; GO:0016324; GO:0016740; GO:0017042; GO:0042493; GO:0042594; GO:0043627; GO:0044245; GO:0045471; GO:1901657 0 0 0 PF00232; P09849 CHOYP_LOC100186561.1.1 m.3367 sp LPH_RABIT 48.374 1476 706 14 39 1474 380 1839 0 1449 LPH_RABIT reviewed Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] LCT LPH Oryctolagus cuniculus (Rabbit) 1926 carbohydrate metabolic process [GO:0005975] GO:0000016; GO:0005975; GO:0016021; GO:0016324; GO:0017042 0 0 0 PF00232; P09849 CHOYP_LOC100371429.1.1 m.13499 sp LPH_RABIT 47.709 1484 714 16 39 1477 380 1846 0 1436 LPH_RABIT reviewed Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] LCT LPH Oryctolagus cuniculus (Rabbit) 1926 carbohydrate metabolic process [GO:0005975] GO:0000016; GO:0005975; GO:0016021; GO:0016324; GO:0017042 0 0 0 PF00232; P09958 CHOYP_FUR.1.1 m.11661 sp FURIN_HUMAN 58.891 613 237 4 7 617 10 609 0 722 FURIN_HUMAN reviewed Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) FURIN FUR PACE PCSK3 Homo sapiens (Human) 794 aging [GO:0007568]; cell proliferation [GO:0008283]; cellular protein metabolic process [GO:0044267]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor processing [GO:0032455]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; positive regulation of cell migration [GO:0030335]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein processing [GO:0016485]; regulation of endopeptidase activity [GO:0052548]; regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045714]; regulation of protein catabolic process [GO:0042176]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral protein processing [GO:0019082] GO:0000139; GO:0002020; GO:0004175; GO:0004252; GO:0004867; GO:0005783; GO:0005789; GO:0005796; GO:0005802; GO:0005886; GO:0006465; GO:0007179; GO:0007568; GO:0008233; GO:0008283; GO:0009986; GO:0016020; GO:0016021; GO:0016485; GO:0016486; GO:0019058; GO:0019082; GO:0022617; GO:0030140; GO:0030198; GO:0030335; GO:0030511; GO:0030574; GO:0031985; GO:0032455; GO:0032804; GO:0032902; GO:0032911; GO:0032940; GO:0042176; GO:0042277; GO:0043043; GO:0044267; GO:0045121; GO:0045714; GO:0046872; GO:0048406; GO:0051044; GO:0052548; GO:0070062 0 0 0 PF01483;PF00082;PF16470; P09958 CHOYP_FURI1.1.2 m.33327 sp FURIN_HUMAN 53.641 714 270 6 7 720 10 662 0 751 FURIN_HUMAN reviewed Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) FURIN FUR PACE PCSK3 Homo sapiens (Human) 794 aging [GO:0007568]; cell proliferation [GO:0008283]; cellular protein metabolic process [GO:0044267]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of transforming growth factor beta1 production [GO:0032911]; nerve growth factor processing [GO:0032455]; nerve growth factor production [GO:0032902]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; positive regulation of cell migration [GO:0030335]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein processing [GO:0016485]; regulation of endopeptidase activity [GO:0052548]; regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045714]; regulation of protein catabolic process [GO:0042176]; secretion by cell [GO:0032940]; signal peptide processing [GO:0006465]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral protein processing [GO:0019082] GO:0000139; GO:0002020; GO:0004175; GO:0004252; GO:0004867; GO:0005783; GO:0005789; GO:0005796; GO:0005802; GO:0005886; GO:0006465; GO:0007179; GO:0007568; GO:0008233; GO:0008283; GO:0009986; GO:0016020; GO:0016021; GO:0016485; GO:0016486; GO:0019058; GO:0019082; GO:0022617; GO:0030140; GO:0030198; GO:0030335; GO:0030511; GO:0030574; GO:0031985; GO:0032455; GO:0032804; GO:0032902; GO:0032911; GO:0032940; GO:0042176; GO:0042277; GO:0043043; GO:0044267; GO:0045121; GO:0045714; GO:0046872; GO:0048406; GO:0051044; GO:0052548; GO:0070062 0 0 0 PF01483;PF00082;PF16470; P0C1Q2 CHOYP_PDE11.2.3 m.39215 sp PDE11_MOUSE 54.775 555 228 5 1 553 385 918 0 623 PDE11_MOUSE reviewed "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)" Pde11a Mus musculus (Mouse) 933 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; signal transduction [GO:0007165] GO:0004118; GO:0005829; GO:0006198; GO:0007165; GO:0030552; GO:0030553; GO:0043204; GO:0046069; GO:0046872; GO:0047555 0 0 0 PF01590;PF00233; P0C218 CHOYP_DDX20.3.3 m.32208 sp DDX20_DANRE 63.793 406 143 1 2 403 3 408 0 553 DDX20_DANRE reviewed Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (DEAD box protein 20) ddx20 Danio rerio (Zebrafish) (Brachydanio rerio) 761 RNA secondary structure unwinding [GO:0010501]; spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0003677; GO:0004004; GO:0005524; GO:0005634; GO:0005829; GO:0010501; GO:0032797; GO:0034719 0 0 0 PF00270;PF00271; P0C6B8 CHOYP_LOC100493788.1.1 m.41774 sp SVEP1_RAT 34.79 3616 2095 60 39 3495 47 3558 0 2145 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P0C6F1 CHOYP_BRAFLDRAFT_108792.1.5 m.21495 sp DYH2_MOUSE 69.294 850 258 2 1 849 2036 2883 0 1285 DYH2_MOUSE reviewed "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) 4456 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0031512; GO:0036156 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; P0C6F1 CHOYP_BRAFLDRAFT_108792.4.5 m.45892 sp DYH2_MOUSE 55.916 1234 537 2 502 1729 425 1657 0 1447 DYH2_MOUSE reviewed "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) 4456 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0031512; GO:0036156 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; P0C6F1 CHOYP_DYH2.1.1 m.28905 sp DYH2_MOUSE 68.299 4044 1258 9 502 4534 425 4455 0 5908 DYH2_MOUSE reviewed "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) 4456 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0031512; GO:0036156 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; P0C6F1 CHOYP_LOC101242248.1.2 m.24785 sp DYH2_MOUSE 73.209 1717 457 2 719 2434 2741 4455 0 2707 DYH2_MOUSE reviewed "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2)" Dnah2 Dnahc2 Mus musculus (Mouse) 4456 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0031512; GO:0036156 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; P0C6R2 CHOYP_LOC100376011.1.1 m.7076 sp ARMC2_BOVIN 37.149 891 506 12 3 866 1 864 0 578 ARMC2_BOVIN reviewed Armadillo repeat-containing protein 2 ARMC2 Bos taurus (Bovine) 865 0 0 0 0 0 0 P0C8Z3 CHOYP_UBP22.3.3 m.43731 sp UBP22_BOVIN 63.364 535 171 7 29 563 5 514 0 681 UBP22_BOVIN reviewed Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22) USP22 Bos taurus (Bovine) 514 "cell cycle [GO:0007049]; histone deubiquitination [GO:0016578]; histone ubiquitination [GO:0016574]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0000124; GO:0004843; GO:0006351; GO:0006355; GO:0006511; GO:0007049; GO:0008270; GO:0010485; GO:0016574; GO:0016578; GO:0030374; GO:0045893; GO:0045931 0 0 0 PF00443;PF02148; P0CG08 CHOYP_GPHRB.1.1 m.27232 sp GPHRB_HUMAN 71.93 399 109 1 1 399 55 450 0 607 GPHRB_HUMAN reviewed Golgi pH regulator B (Protein GPR89B) GPR89B GPHRB GPR89C HSPC201 Homo sapiens (Human) 455 protein transport [GO:0015031] GO:0000139; GO:0005244; GO:0015031; GO:0016021 0 0 0 PF12430;PF12537; P0CY46 CHOYP_EGFR.1.3 m.30285 sp EGFR_APIME 43.933 1261 587 29 163 1382 3 1184 0 993 EGFR_APIME reviewed Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) Egfr Apis mellifera (Honeybee) 1292 multicellular organism development [GO:0007275]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0007275; GO:0016021 0 0 0 PF00757;PF14843;PF07714;PF01030; P0CY46 CHOYP_EGFR.3.3 m.67034 sp EGFR_APIME 43.471 1256 561 30 2 1216 37 1184 0 965 EGFR_APIME reviewed Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) Egfr Apis mellifera (Honeybee) 1292 multicellular organism development [GO:0007275]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0007275; GO:0016021 0 0 0 PF00757;PF14843;PF07714;PF01030; P0CY46 CHOYP_LOC100866004.1.1 m.41322 sp EGFR_APIME 43.178 1290 580 32 163 1407 3 1184 0 988 EGFR_APIME reviewed Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) Egfr Apis mellifera (Honeybee) 1292 multicellular organism development [GO:0007275]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0007275; GO:0016021 0 0 0 PF00757;PF14843;PF07714;PF01030; P0DM42 CHOYP_ACT.8.27 m.15996 sp ACT3_CAEEL 90.909 363 33 0 4 366 3 365 0 702 ACT3_CAEEL reviewed Actin-3 act-3 T04C12.4 Caenorhabditis elegans 376 cortical actin cytoskeleton organization [GO:0030866]; embryo development ending in birth or egg hatching [GO:0009792]; mitotic cytokinesis [GO:0000281] GO:0000281; GO:0005524; GO:0005865; GO:0009792; GO:0030866 0 0 0 PF00022; P10040 CHOYP_BRAFLDRAFT_86846.1.3 m.13594 sp CRB_DROME 31.804 1962 1072 68 2134 3995 274 2069 0 845 CRB_DROME reviewed Protein crumbs (95F) crb CG6383 Drosophila melanogaster (Fruit fly) 2146 "adherens junction organization [GO:0034332]; cell-cell junction assembly [GO:0007043]; cell morphogenesis involved in Malpighian tubule morphogenesis [GO:0061336]; centrosome localization [GO:0051642]; compound eye morphogenesis [GO:0001745]; compound eye photoreceptor development [GO:0042051]; dorsal closure, amnioserosa morphology change [GO:0046664]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; liquid clearance, open tracheal system [GO:0035002]; maintenance of apical/basal cell polarity [GO:0035090]; Malpighian tubule morphogenesis [GO:0007443]; membrane organization [GO:0061024]; morphogenesis of an epithelium [GO:0002009]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of organ growth [GO:0046621]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nervous system development [GO:0007399]; nuclear chromosome segregation [GO:0098813]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphorylation [GO:0042327]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; regulation of hippo signaling [GO:0035330]; regulation of imaginal disc growth [GO:0045570]; regulation of intracellular protein transport [GO:0033157]; regulation of protein localization [GO:0032880]; rhabdomere development [GO:0042052]; rhabdomere morphogenesis [GO:0061541]; salivary gland development [GO:0007431]; salivary gland morphogenesis [GO:0007435]; tube morphogenesis [GO:0035239]; zonula adherens assembly [GO:0045186]; zonula adherens maintenance [GO:0045218]" GO:0001738; GO:0001745; GO:0002009; GO:0005080; GO:0005509; GO:0005886; GO:0005918; GO:0007043; GO:0007163; GO:0007399; GO:0007424; GO:0007431; GO:0007435; GO:0007443; GO:0008104; GO:0008284; GO:0016021; GO:0016028; GO:0016324; GO:0016327; GO:0016332; GO:0016334; GO:0030507; GO:0032435; GO:0032880; GO:0033157; GO:0034332; GO:0035002; GO:0035003; GO:0035088; GO:0035090; GO:0035239; GO:0035330; GO:0042051; GO:0042052; GO:0042327; GO:0045186; GO:0045197; GO:0045198; GO:0045218; GO:0045494; GO:0045570; GO:0045746; GO:0046621; GO:0046664; GO:0048477; GO:0050821; GO:0051642; GO:0061024; GO:0061336; GO:0061541; GO:0098813 0 0 0 PF00008;PF07645;PF12661;PF00054;PF02210; P10040 CHOYP_BRAFLDRAFT_86846.2.3 m.42836 sp CRB_DROME 31.412 1926 1032 61 251 2019 276 2069 0 836 CRB_DROME reviewed Protein crumbs (95F) crb CG6383 Drosophila melanogaster (Fruit fly) 2146 "adherens junction organization [GO:0034332]; cell-cell junction assembly [GO:0007043]; cell morphogenesis involved in Malpighian tubule morphogenesis [GO:0061336]; centrosome localization [GO:0051642]; compound eye morphogenesis [GO:0001745]; compound eye photoreceptor development [GO:0042051]; dorsal closure, amnioserosa morphology change [GO:0046664]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; liquid clearance, open tracheal system [GO:0035002]; maintenance of apical/basal cell polarity [GO:0035090]; Malpighian tubule morphogenesis [GO:0007443]; membrane organization [GO:0061024]; morphogenesis of an epithelium [GO:0002009]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of organ growth [GO:0046621]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nervous system development [GO:0007399]; nuclear chromosome segregation [GO:0098813]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphorylation [GO:0042327]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; regulation of hippo signaling [GO:0035330]; regulation of imaginal disc growth [GO:0045570]; regulation of intracellular protein transport [GO:0033157]; regulation of protein localization [GO:0032880]; rhabdomere development [GO:0042052]; rhabdomere morphogenesis [GO:0061541]; salivary gland development [GO:0007431]; salivary gland morphogenesis [GO:0007435]; tube morphogenesis [GO:0035239]; zonula adherens assembly [GO:0045186]; zonula adherens maintenance [GO:0045218]" GO:0001738; GO:0001745; GO:0002009; GO:0005080; GO:0005509; GO:0005886; GO:0005918; GO:0007043; GO:0007163; GO:0007399; GO:0007424; GO:0007431; GO:0007435; GO:0007443; GO:0008104; GO:0008284; GO:0016021; GO:0016028; GO:0016324; GO:0016327; GO:0016332; GO:0016334; GO:0030507; GO:0032435; GO:0032880; GO:0033157; GO:0034332; GO:0035002; GO:0035003; GO:0035088; GO:0035090; GO:0035239; GO:0035330; GO:0042051; GO:0042052; GO:0042327; GO:0045186; GO:0045197; GO:0045198; GO:0045218; GO:0045494; GO:0045570; GO:0045746; GO:0046621; GO:0046664; GO:0048477; GO:0050821; GO:0051642; GO:0061024; GO:0061336; GO:0061541; GO:0098813 0 0 0 PF00008;PF07645;PF12661;PF00054;PF02210; P10040 CHOYP_BRAFLDRAFT_86846.3.3 m.53453 sp CRB_DROME 32.595 1942 1064 65 430 2274 276 2069 0 876 CRB_DROME reviewed Protein crumbs (95F) crb CG6383 Drosophila melanogaster (Fruit fly) 2146 "adherens junction organization [GO:0034332]; cell-cell junction assembly [GO:0007043]; cell morphogenesis involved in Malpighian tubule morphogenesis [GO:0061336]; centrosome localization [GO:0051642]; compound eye morphogenesis [GO:0001745]; compound eye photoreceptor development [GO:0042051]; dorsal closure, amnioserosa morphology change [GO:0046664]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; liquid clearance, open tracheal system [GO:0035002]; maintenance of apical/basal cell polarity [GO:0035090]; Malpighian tubule morphogenesis [GO:0007443]; membrane organization [GO:0061024]; morphogenesis of an epithelium [GO:0002009]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of organ growth [GO:0046621]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; nervous system development [GO:0007399]; nuclear chromosome segregation [GO:0098813]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; photoreceptor cell maintenance [GO:0045494]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphorylation [GO:0042327]; protein localization [GO:0008104]; protein stabilization [GO:0050821]; regulation of hippo signaling [GO:0035330]; regulation of imaginal disc growth [GO:0045570]; regulation of intracellular protein transport [GO:0033157]; regulation of protein localization [GO:0032880]; rhabdomere development [GO:0042052]; rhabdomere morphogenesis [GO:0061541]; salivary gland development [GO:0007431]; salivary gland morphogenesis [GO:0007435]; tube morphogenesis [GO:0035239]; zonula adherens assembly [GO:0045186]; zonula adherens maintenance [GO:0045218]" GO:0001738; GO:0001745; GO:0002009; GO:0005080; GO:0005509; GO:0005886; GO:0005918; GO:0007043; GO:0007163; GO:0007399; GO:0007424; GO:0007431; GO:0007435; GO:0007443; GO:0008104; GO:0008284; GO:0016021; GO:0016028; GO:0016324; GO:0016327; GO:0016332; GO:0016334; GO:0030507; GO:0032435; GO:0032880; GO:0033157; GO:0034332; GO:0035002; GO:0035003; GO:0035088; GO:0035090; GO:0035239; GO:0035330; GO:0042051; GO:0042052; GO:0042327; GO:0045186; GO:0045197; GO:0045198; GO:0045218; GO:0045494; GO:0045570; GO:0045746; GO:0046621; GO:0046664; GO:0048477; GO:0050821; GO:0051642; GO:0061024; GO:0061336; GO:0061541; GO:0098813 0 0 0 PF00008;PF07645;PF12661;PF00054;PF02210; P10079 CHOYP_BRAFLDRAFT_63459.3.3 m.51854 sp FBP1_STRPU 51.318 645 309 5 62 701 214 858 0 628 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_FBP1.2.7 m.21875 sp FBP1_STRPU 49.749 597 260 2 2 560 263 857 0 567 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_FBP1.4.7 m.34465 sp FBP1_STRPU 50.328 610 303 0 560 1169 248 857 0 622 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_FBP1.6.7 m.51152 sp FBP1_STRPU 51.624 585 283 0 1 585 271 855 0 577 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_FBP1.7.7 m.62017 sp FBP1_STRPU 46.505 658 330 7 272 909 75 730 0 557 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_LOC100892166.1.1 m.41659 sp FBP1_STRPU 37.647 935 539 12 7 938 6 899 0 605 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_TRIADDRAFT_57304.1.1 m.34461 sp FBP1_STRPU 49.861 720 361 0 266 985 214 933 0 713 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10090 CHOYP_LOC100374352.1.3 m.12967 sp WHITE_DROME 47.138 594 301 6 34 622 100 685 0 582 WHITE_DROME reviewed Protein white w CG2759 Drosophila melanogaster (Fruit fly) 687 cellular biogenic amine biosynthetic process [GO:0042401]; cGMP transport [GO:0070731]; compound eye pigmentation [GO:0048072]; eye pigment metabolic process [GO:0042441]; eye pigment precursor transport [GO:0006856]; gravitaxis [GO:0042332]; male courtship behavior [GO:0008049]; memory [GO:0007613]; ommochrome biosynthetic process [GO:0006727] GO:0004888; GO:0005524; GO:0005886; GO:0006727; GO:0006856; GO:0007613; GO:0008049; GO:0016021; GO:0031409; GO:0031410; GO:0042332; GO:0042401; GO:0042441; GO:0042626; GO:0048072; GO:0070731 0 0 0 PF01061;PF00005; P10090 CHOYP_LOC100374352.3.3 m.28604 sp WHITE_DROME 44.876 644 324 10 33 657 54 685 0 570 WHITE_DROME reviewed Protein white w CG2759 Drosophila melanogaster (Fruit fly) 687 cellular biogenic amine biosynthetic process [GO:0042401]; cGMP transport [GO:0070731]; compound eye pigmentation [GO:0048072]; eye pigment metabolic process [GO:0042441]; eye pigment precursor transport [GO:0006856]; gravitaxis [GO:0042332]; male courtship behavior [GO:0008049]; memory [GO:0007613]; ommochrome biosynthetic process [GO:0006727] GO:0004888; GO:0005524; GO:0005886; GO:0006727; GO:0006856; GO:0007613; GO:0008049; GO:0016021; GO:0031409; GO:0031410; GO:0042332; GO:0042401; GO:0042441; GO:0042626; GO:0048072; GO:0070731 0 0 0 PF01061;PF00005; P10351 CHOYP_LOC100636568.1.1 m.16013 sp XDH_DROME 33.308 1309 771 26 77 1304 25 1312 0 642 XDH_DROME reviewed Xanthine dehydrogenase (XD) (EC 1.17.1.4) (Protein rosy locus) ry XDH CG7642 Drosophila melanogaster (Fruit fly) 1335 arginine metabolic process [GO:0006525]; compound eye pigmentation [GO:0048072]; determination of adult lifespan [GO:0008340]; glycerophospholipid metabolic process [GO:0006650]; purine nucleobase metabolic process [GO:0006144]; pyrimidine nucleobase metabolic process [GO:0006206]; response to ethanol [GO:0045471]; tryptophan metabolic process [GO:0006568]; xanthine catabolic process [GO:0009115] GO:0004854; GO:0004855; GO:0005506; GO:0005777; GO:0005829; GO:0005875; GO:0006144; GO:0006206; GO:0006525; GO:0006568; GO:0006650; GO:0008340; GO:0009055; GO:0009115; GO:0016614; GO:0016903; GO:0043546; GO:0045471; GO:0048072; GO:0050660; GO:0051537 0 0 cd00207; PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; P11029 CHOYP_ACAC.1.2 m.16888 sp ACAC_CHICK 68.656 2262 679 14 89 2336 75 2320 0 3237 ACAC_CHICK reviewed Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACAC Gallus gallus (Chicken) 2324 "fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of biological quality [GO:0065008]; regulation of gene expression, epigenetic [GO:0040029]; response to carbohydrate [GO:0009743]; response to fatty acid [GO:0070542]; response to thyroid hormone [GO:0097066]; transport [GO:0006810]" GO:0003989; GO:0004075; GO:0005102; GO:0005524; GO:0005623; GO:0005737; GO:0006633; GO:0006810; GO:0009374; GO:0009743; GO:0010628; GO:0032810; GO:0040029; GO:0045893; GO:0046872; GO:0046966; GO:0050692; GO:0065008; GO:0070542; GO:0097066; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; P11181 CHOYP_DBT.1.1 m.4866 sp ODB2_BOVIN 54.91 499 198 8 1 489 1 482 0 530 ODB2_BOVIN reviewed "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)" DBT Bos taurus (Bovine) 482 metabolic process [GO:0008152] GO:0008152; GO:0042645; GO:0043754 0 0 0 PF00198;PF00364;PF02817; P11387 CHOYP_TOP1.5.5 m.61515 sp TOP1_HUMAN 74.281 556 143 0 375 930 210 765 0 895 TOP1_HUMAN reviewed DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) TOP1 Homo sapiens (Human) 765 chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; protein sumoylation [GO:0016925]; response to drug [GO:0042493]; viral process [GO:0016032] GO:0000932; GO:0001046; GO:0003677; GO:0003682; GO:0003917; GO:0003918; GO:0005634; GO:0005654; GO:0005730; GO:0006260; GO:0006265; GO:0006338; GO:0007059; GO:0007623; GO:0012501; GO:0016032; GO:0016310; GO:0016925; GO:0031298; GO:0032922; GO:0040016; GO:0042493; GO:0043204; GO:0044822 0 0 0 PF14370;PF01028;PF02919; P11498 CHOYP_LOC100367726.1.2 m.47322 sp PYC_HUMAN 69.466 1143 348 1 81 1223 37 1178 0 1680 PYC_HUMAN reviewed "Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)" PC Homo sapiens (Human) 1178 biotin metabolic process [GO:0006768]; gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; negative regulation of gene expression [GO:0010629]; oxaloacetate metabolic process [GO:0006107]; positive regulation by host of viral process [GO:0044794]; positive regulation by host of viral release from host cell [GO:0044791]; pyruvate metabolic process [GO:0006090]; viral RNA genome packaging [GO:0019074] GO:0003677; GO:0004075; GO:0004736; GO:0005524; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006090; GO:0006094; GO:0006107; GO:0006629; GO:0006768; GO:0009374; GO:0010629; GO:0019074; GO:0044791; GO:0044794; GO:0046872 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. 0 0 PF02785;PF00289;PF00364;PF02786;PF00682;PF02436; P11654 CHOYP_NUP210.1.1 m.9327 sp PO210_RAT 34.224 1908 1173 31 34 1906 23 1883 0 1086 PO210_RAT reviewed Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) Nup210 Gp210 Pom210 Rattus norvegicus (Rat) 1886 mRNA transport [GO:0051028]; protein transport [GO:0015031] GO:0005643; GO:0005789; GO:0015031; GO:0016021; GO:0017056; GO:0031965; GO:0046983; GO:0051028 0 0 0 PF02368; P11717 CHOYP_LOC100366918.1.1 m.31506 sp MPRI_HUMAN 34.411 2412 1352 78 66 2355 53 2356 0 1243 MPRI_HUMAN reviewed Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) IGF2R MPRI Homo sapiens (Human) 2491 liver development [GO:0001889]; organ regeneration [GO:0031100]; positive regulation of apoptotic process [GO:0043065]; post-embryonic development [GO:0009791]; receptor-mediated endocytosis [GO:0006898]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] GO:0001889; GO:0001948; GO:0001972; GO:0004872; GO:0004930; GO:0005010; GO:0005215; GO:0005537; GO:0005615; GO:0005641; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005802; GO:0005887; GO:0005925; GO:0006898; GO:0007165; GO:0007283; GO:0009791; GO:0009986; GO:0016020; GO:0030118; GO:0030133; GO:0030139; GO:0030140; GO:0031100; GO:0032526; GO:0032588; GO:0042802; GO:0043065; GO:0048471; GO:0051219; GO:0070062 0 0 cd00062; PF00878;PF00040; P11833 CHOYP_LOC373275.6.7 m.57854 sp TBB_PARLI 91.826 367 24 1 24 384 64 430 0 664 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_LOC373275.6.7 m.57855 sp TBB_PARLI 96.341 328 12 0 1 328 1 328 0 653 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB.1.7 m.10725 sp TBB_PARLI 89.13 322 10 1 1 322 1 297 0 573 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB.3.7 m.42380 sp TBB_PARLI 98.881 268 3 0 1 268 1 268 0 561 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB.4.7 m.51782 sp TBB_PARLI 90.814 381 12 1 1 381 73 430 0 701 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB.7.7 m.66811 sp TBB_PARLI 96.481 341 12 0 52 392 1 341 0 679 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4.1.1 m.40048 sp TBB_PARLI 94.754 305 16 0 254 558 142 446 0 607 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4B.1.7 m.12262 sp TBB_PARLI 96.296 405 15 0 1 405 1 405 0 813 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4B.1.7 m.12263 sp TBB_PARLI 98.396 374 6 0 1 374 73 446 0 773 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4B.2.7 m.12352 sp TBB_PARLI 95.388 412 19 0 1 412 1 412 0 820 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4B.3.7 m.22778 sp TBB_PARLI 97.768 448 9 1 1 448 1 447 0 921 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4B.5.7 m.41160 sp TBB_PARLI 97.085 446 13 0 87 532 1 446 0 920 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4B.5.7 m.41161 sp TBB_PARLI 96.221 344 13 0 1 344 1 344 0 686 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11833 CHOYP_TBB4B.7.7 m.63980 sp TBB_PARLI 95.013 381 19 0 40 420 1 381 0 744 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P11881 CHOYP_LOC100533406.1.2 m.38909 sp ITPR1_MOUSE 60.478 2806 906 42 3 2681 6 2735 0 3262 ITPR1_MOUSE reviewed "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Protein PCD-6) (Purkinje cell protein 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" Itpr1 Insp3r Pcd6 Pcp1 Mus musculus (Mouse) 2749 calcium ion transport [GO:0006816]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial fluid transport [GO:0042045]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of calcium-mediated signaling [GO:0050849]; post-embryonic development [GO:0009791]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; voluntary musculoskeletal movement [GO:0050882] GO:0001666; GO:0005220; GO:0005635; GO:0005637; GO:0005730; GO:0005737; GO:0005783; GO:0005789; GO:0005955; GO:0006816; GO:0009791; GO:0014069; GO:0015278; GO:0016020; GO:0016021; GO:0016529; GO:0019855; GO:0031088; GO:0031094; GO:0032469; GO:0035091; GO:0042045; GO:0043234; GO:0050849; GO:0050882; GO:0051209; GO:0070059 0 0 0 PF08709;PF00520;PF02815;PF08454;PF01365; P11940 CHOYP_LOC100370010.1.5 m.2489 sp PABP1_HUMAN 74.813 401 98 3 6 405 1 399 0 636 PABP1_HUMAN reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 Homo sapiens (Human) 636 "gene silencing by RNA [GO:0031047]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulation of mRNA stability [GO:0043488]; translational initiation [GO:0006413]" GO:0000166; GO:0000184; GO:0000289; GO:0000398; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006378; GO:0006413; GO:0008022; GO:0008143; GO:0008266; GO:0008494; GO:0010494; GO:0016020; GO:0030529; GO:0031047; GO:0036464; GO:0043488; GO:0044822; GO:0045070; GO:0048255; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:2000623 0 0 0 PF00658;PF00076; P11940 CHOYP_LOC100370010.5.5 m.40351 sp PABP1_HUMAN 76.154 390 92 1 6 395 1 389 0 631 PABP1_HUMAN reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 Homo sapiens (Human) 636 "gene silencing by RNA [GO:0031047]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulation of mRNA stability [GO:0043488]; translational initiation [GO:0006413]" GO:0000166; GO:0000184; GO:0000289; GO:0000398; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006378; GO:0006413; GO:0008022; GO:0008143; GO:0008266; GO:0008494; GO:0010494; GO:0016020; GO:0030529; GO:0031047; GO:0036464; GO:0043488; GO:0044822; GO:0045070; GO:0048255; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:2000623 0 0 0 PF00658;PF00076; P11940 CHOYP_PABP.1.1 m.57670 sp PABP1_HUMAN 68.421 437 99 4 6 441 1 399 0 618 PABP1_HUMAN reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 Homo sapiens (Human) 636 "gene silencing by RNA [GO:0031047]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulation of mRNA stability [GO:0043488]; translational initiation [GO:0006413]" GO:0000166; GO:0000184; GO:0000289; GO:0000398; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006378; GO:0006413; GO:0008022; GO:0008143; GO:0008266; GO:0008494; GO:0010494; GO:0016020; GO:0030529; GO:0031047; GO:0036464; GO:0043488; GO:0044822; GO:0045070; GO:0048255; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:2000623 0 0 0 PF00658;PF00076; P12261 CHOYP_ABCF2.1.2 m.28361 sp EF1G_ARTSA 60.557 431 157 3 7 425 1 430 0 539 EF1G_ARTSA reviewed Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) 0 Artemia salina (Brine shrimp) 430 0 GO:0003746 0 0 0 PF00647;PF00043;PF02798; P12261 CHOYP_EF1G.3.3 m.63510 sp EF1G_ARTSA 61.124 427 151 5 1 414 1 425 0 531 EF1G_ARTSA reviewed Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) 0 Artemia salina (Brine shrimp) 430 0 GO:0003746 0 0 0 PF00647;PF00043;PF02798; P12265 CHOYP_LOC100733204.1.1 m.43884 sp BGLR_MOUSE 53.292 638 286 6 9 639 15 647 0 713 BGLR_MOUSE reviewed Beta-glucuronidase (EC 3.2.1.31) Gusb Gus Gus-s Mus musculus (Mouse) 648 carbohydrate metabolic process [GO:0005975] GO:0004566; GO:0005102; GO:0005615; GO:0005764; GO:0005783; GO:0005975; GO:0016020; GO:0016787; GO:0019904; GO:0043231; GO:0070062 0 0 0 PF00703;PF02836;PF02837; P12276 CHOYP_FASN.3.4 m.60278 sp FAS_CHICK 49.96 2520 1166 32 64 2521 3 2489 0 2447 FAS_CHICK reviewed Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Gallus gallus (Chicken) 2512 fatty acid biosynthetic process [GO:0006633]; lactate metabolic process [GO:0006089]; positive regulation of appetite [GO:0032100] GO:0003697; GO:0004312; GO:0004313; GO:0004314; GO:0004315; GO:0004316; GO:0004317; GO:0004319; GO:0004320; GO:0005623; GO:0006089; GO:0006633; GO:0016295; GO:0016296; GO:0031177; GO:0032100; GO:0047117; GO:0047451; GO:0102132 0 0 0 PF00698;PF00107;PF16197;PF00109;PF02801;PF08659;PF00550;PF14765;PF00975; P12276 CHOYP_LOC100374692.1.1 m.13459 sp FAS_CHICK 38.06 2567 1434 50 4 2482 2 2500 0 1647 FAS_CHICK reviewed Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Gallus gallus (Chicken) 2512 fatty acid biosynthetic process [GO:0006633]; lactate metabolic process [GO:0006089]; positive regulation of appetite [GO:0032100] GO:0003697; GO:0004312; GO:0004313; GO:0004314; GO:0004315; GO:0004316; GO:0004317; GO:0004319; GO:0004320; GO:0005623; GO:0006089; GO:0006633; GO:0016295; GO:0016296; GO:0031177; GO:0032100; GO:0047117; GO:0047451; GO:0102132 0 0 0 PF00698;PF00107;PF16197;PF00109;PF02801;PF08659;PF00550;PF14765;PF00975; P12370 CHOYP_CAPLA.1.2 m.51979 sp KAPC_DROME 85.546 339 49 0 34 372 15 353 0 620 KAPC_DROME reviewed cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) 353 "anesthesia-resistant memory [GO:0007615]; anterior/posterior pattern specification, imaginal disc [GO:0007448]; behavioral response to ethanol [GO:0048149]; cAMP-mediated signaling [GO:0019933]; compound eye development [GO:0048749]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing morphogenesis [GO:0007476]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotor rhythm [GO:0045475]; memory [GO:0007613]; modulation of synaptic transmission [GO:0050804]; negative regulation of smoothened signaling pathway [GO:0045879]; olfactory learning [GO:0008355]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte microtubule cytoskeleton polarization [GO:0008103]; oogenesis [GO:0048477]; positive regulation of hh target transcription factor activity [GO:0007228]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of bicoid mRNA localization [GO:0008359]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of pole plasm oskar mRNA localization [GO:0007317]; rhythmic behavior [GO:0007622]; thermosensory behavior [GO:0040040]" GO:0004674; GO:0004691; GO:0005524; GO:0005737; GO:0005886; GO:0005952; GO:0006468; GO:0007228; GO:0007314; GO:0007317; GO:0007448; GO:0007476; GO:0007480; GO:0007611; GO:0007612; GO:0007613; GO:0007615; GO:0007622; GO:0008103; GO:0008355; GO:0008359; GO:0019933; GO:0030425; GO:0040040; GO:0042981; GO:0044297; GO:0045187; GO:0045475; GO:0045879; GO:0048149; GO:0048477; GO:0048749; GO:0050804 0 0 0 PF00069; P12370 CHOYP_CAPLA.2.2 m.62387 sp KAPC_DROME 84.703 353 52 1 1 351 1 353 0 631 KAPC_DROME reviewed cAMP-dependent protein kinase catalytic subunit (PKA C) (EC 2.7.11.11) Pka-C1 CdkA DC0 CG4379 Drosophila melanogaster (Fruit fly) 353 "anesthesia-resistant memory [GO:0007615]; anterior/posterior pattern specification, imaginal disc [GO:0007448]; behavioral response to ethanol [GO:0048149]; cAMP-mediated signaling [GO:0019933]; compound eye development [GO:0048749]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing morphogenesis [GO:0007476]; learning [GO:0007612]; learning or memory [GO:0007611]; locomotor rhythm [GO:0045475]; memory [GO:0007613]; modulation of synaptic transmission [GO:0050804]; negative regulation of smoothened signaling pathway [GO:0045879]; olfactory learning [GO:0008355]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte microtubule cytoskeleton polarization [GO:0008103]; oogenesis [GO:0048477]; positive regulation of hh target transcription factor activity [GO:0007228]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of bicoid mRNA localization [GO:0008359]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of pole plasm oskar mRNA localization [GO:0007317]; rhythmic behavior [GO:0007622]; thermosensory behavior [GO:0040040]" GO:0004674; GO:0004691; GO:0005524; GO:0005737; GO:0005886; GO:0005952; GO:0006468; GO:0007228; GO:0007314; GO:0007317; GO:0007448; GO:0007476; GO:0007480; GO:0007611; GO:0007612; GO:0007613; GO:0007615; GO:0007622; GO:0008103; GO:0008355; GO:0008359; GO:0019933; GO:0030425; GO:0040040; GO:0042981; GO:0044297; GO:0045187; GO:0045475; GO:0045879; GO:0048149; GO:0048477; GO:0048749; GO:0050804 0 0 0 PF00069; P12613 CHOYP_LOC100115577.1.1 m.21791 sp TCPA_DROME 78.09 534 116 1 77 610 23 555 0 857 TCPA_DROME reviewed T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-cp1 CCT-1 Tcp-1 CG5374 Drosophila melanogaster (Fruit fly) 557 mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; ovarian follicle cell development [GO:0030707]; phagocytosis [GO:0006909]; protein folding [GO:0006457] GO:0005524; GO:0005829; GO:0005875; GO:0006457; GO:0006909; GO:0007052; GO:0030707; GO:0090307 0 0 cd03335; PF00118; P12955 CHOYP_LOC100373864.1.2 m.16543 sp PEPD_HUMAN 64.768 474 167 0 31 504 7 480 0 672 PEPD_HUMAN reviewed Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) PEPD PRD Homo sapiens (Human) 493 cellular amino acid metabolic process [GO:0006520]; collagen catabolic process [GO:0030574]; proteolysis [GO:0006508] GO:0004177; GO:0004181; GO:0006508; GO:0006520; GO:0030145; GO:0030574; GO:0070062; GO:0102009 0 0 0 PF05195;PF00557; P12955 CHOYP_LOC100373864.2.2 m.55132 sp PEPD_HUMAN 64.356 404 144 0 1 404 16 419 0 577 PEPD_HUMAN reviewed Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) PEPD PRD Homo sapiens (Human) 493 cellular amino acid metabolic process [GO:0006520]; collagen catabolic process [GO:0030574]; proteolysis [GO:0006508] GO:0004177; GO:0004181; GO:0006508; GO:0006520; GO:0030145; GO:0030574; GO:0070062; GO:0102009 0 0 0 PF05195;PF00557; P13195 CHOYP_AAEL_AAEL007787.1.1 m.13188 sp HEM1_RAT 47.531 648 249 9 6 588 7 628 0 584 HEM1_RAT reviewed "5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS-H) (EC 2.3.1.37) (5-aminolevulinic acid synthase 1) (Delta-ALA synthase 1) (Delta-aminolevulinate synthase 1)" Alas1 Rattus norvegicus (Rat) 642 cellular response to insulin stimulus [GO:0032869]; cellular response to organic cyclic compound [GO:0071407]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to cAMP [GO:0051591]; response to cobalt ion [GO:0032025]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to gonadotropin [GO:0034698]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to nickel cation [GO:0010045]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; response to platinum ion [GO:0070541] GO:0001666; GO:0003870; GO:0005739; GO:0005759; GO:0006782; GO:0009635; GO:0010033; GO:0010045; GO:0014070; GO:0030170; GO:0031667; GO:0032025; GO:0032869; GO:0034698; GO:0042493; GO:0045471; GO:0051591; GO:0070541; GO:0071407 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. 0 0 PF00155;PF09029; P13395 CHOYP_SPTCA.1.2 m.1905 sp SPTCA_DROME 68.451 2447 736 5 1 2443 1 2415 0 3433 SPTCA_DROME reviewed Spectrin alpha chain alpha-Spec SPEC-A CG1977 Drosophila melanogaster (Fruit fly) 2415 actin filament capping [GO:0051693]; axon midline choice point recognition [GO:0016199]; central nervous system development [GO:0007417]; epithelium development [GO:0060429]; fusome organization [GO:0045478]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst formation [GO:0030727]; germarium-derived oocyte fate determination [GO:0007294]; germ-line cyst formation [GO:0048134]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; neuromuscular synaptic transmission [GO:0007274]; oocyte construction [GO:0007308]; ovarian follicle cell development [GO:0030707]; plasma membrane organization [GO:0007009]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807]; spectrosome organization [GO:0030721] GO:0003779; GO:0005509; GO:0005794; GO:0005811; GO:0005886; GO:0005938; GO:0007009; GO:0007026; GO:0007274; GO:0007293; GO:0007294; GO:0007308; GO:0007417; GO:0008017; GO:0008091; GO:0008092; GO:0008360; GO:0016199; GO:0016323; GO:0030707; GO:0030721; GO:0030727; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048134; GO:0048790; GO:0050807; GO:0051693; GO:0060429 0 0 0 PF13499;PF08726;PF00018;PF00435; P13395 CHOYP_SPTCA.2.2 m.25615 sp SPTCA_DROME 68.873 2432 736 5 1 2428 1 2415 0 3439 SPTCA_DROME reviewed Spectrin alpha chain alpha-Spec SPEC-A CG1977 Drosophila melanogaster (Fruit fly) 2415 actin filament capping [GO:0051693]; axon midline choice point recognition [GO:0016199]; central nervous system development [GO:0007417]; epithelium development [GO:0060429]; fusome organization [GO:0045478]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst formation [GO:0030727]; germarium-derived oocyte fate determination [GO:0007294]; germ-line cyst formation [GO:0048134]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; neuromuscular synaptic transmission [GO:0007274]; oocyte construction [GO:0007308]; ovarian follicle cell development [GO:0030707]; plasma membrane organization [GO:0007009]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807]; spectrosome organization [GO:0030721] GO:0003779; GO:0005509; GO:0005794; GO:0005811; GO:0005886; GO:0005938; GO:0007009; GO:0007026; GO:0007274; GO:0007293; GO:0007294; GO:0007308; GO:0007417; GO:0008017; GO:0008091; GO:0008092; GO:0008360; GO:0016199; GO:0016323; GO:0030707; GO:0030721; GO:0030727; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048134; GO:0048790; GO:0050807; GO:0051693; GO:0060429 0 0 0 PF13499;PF08726;PF00018;PF00435; P13667 CHOYP_PDIA4.1.1 m.54958 sp PDIA4_HUMAN 54.031 583 263 5 43 621 64 645 0 639 PDIA4_HUMAN reviewed Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72) PDIA4 ERP70 ERP72 Homo sapiens (Human) 645 cell redox homeostasis [GO:0045454]; chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein secretion [GO:0009306]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005788; GO:0006457; GO:0009306; GO:0009986; GO:0034976; GO:0042470; GO:0044822; GO:0045454; GO:0061077 0 0 0 PF00085; P13808 CHOYP_B3A2.1.2 m.7402 sp B3A2_MOUSE 45.234 1070 506 13 414 1461 226 1237 0 862 B3A2_MOUSE reviewed Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein) (B3RP) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2) Slc4a2 Ae2 Mus musculus (Mouse) 1237 chloride transport [GO:0006821]; regulation of intracellular pH [GO:0051453] GO:0005452; GO:0005887; GO:0005925; GO:0006821; GO:0015108; GO:0015301; GO:0016020; GO:0016323; GO:0051453 0 0 0 PF07565;PF00955; P13808 CHOYP_B3A2.2.2 m.64798 sp B3A2_MOUSE 45.985 1046 504 15 414 1432 226 1237 0 861 B3A2_MOUSE reviewed Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein) (B3RP) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2) Slc4a2 Ae2 Mus musculus (Mouse) 1237 chloride transport [GO:0006821]; regulation of intracellular pH [GO:0051453] GO:0005452; GO:0005887; GO:0005925; GO:0006821; GO:0015108; GO:0015301; GO:0016020; GO:0016323; GO:0051453 0 0 0 PF07565;PF00955; P14099 CHOYP_PDE2A.2.3 m.46540 sp PDE2A_BOVIN 61.155 502 191 2 660 1161 388 885 0 676 PDE2A_BOVIN reviewed "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" PDE2A Bos taurus (Bovine) 921 "cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to drug [GO:0035690]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; GMP catabolic process [GO:0046038]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of protein import into nucleus, translocation [GO:0033159]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; protein targeting to mitochondrion [GO:0006626]; regulation of cAMP metabolic process [GO:0030814]; signal transduction [GO:0007165]" GO:0000122; GO:0004112; GO:0004118; GO:0005634; GO:0005737; GO:0005759; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006198; GO:0006626; GO:0007165; GO:0008144; GO:0019933; GO:0019934; GO:0030553; GO:0030814; GO:0030818; GO:0033159; GO:0035690; GO:0036006; GO:0042734; GO:0043116; GO:0043117; GO:0046038; GO:0046069; GO:0046872; GO:0048471; GO:0050729; GO:0061028; GO:0071260; GO:0071321; GO:0097011 0 0 0 PF01590;PF13185;PF00233; P14099 CHOYP_PDE2A.3.3 m.60225 sp PDE2A_BOVIN 51.009 892 401 11 27 898 10 885 0 888 PDE2A_BOVIN reviewed "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" PDE2A Bos taurus (Bovine) 921 "cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to drug [GO:0035690]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; GMP catabolic process [GO:0046038]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of protein import into nucleus, translocation [GO:0033159]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; protein targeting to mitochondrion [GO:0006626]; regulation of cAMP metabolic process [GO:0030814]; signal transduction [GO:0007165]" GO:0000122; GO:0004112; GO:0004118; GO:0005634; GO:0005737; GO:0005759; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006198; GO:0006626; GO:0007165; GO:0008144; GO:0019933; GO:0019934; GO:0030553; GO:0030814; GO:0030818; GO:0033159; GO:0035690; GO:0036006; GO:0042734; GO:0043116; GO:0043117; GO:0046038; GO:0046069; GO:0046872; GO:0048471; GO:0050729; GO:0061028; GO:0071260; GO:0071321; GO:0097011 0 0 0 PF01590;PF13185;PF00233; P14576 CHOYP_SRP54.1.2 m.21986 sp SRP54_MOUSE 85.4 500 73 0 1 500 1 500 0 900 SRP54_MOUSE reviewed Signal recognition particle 54 kDa protein (SRP54) Srp54 Mus musculus (Mouse) 504 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005786; GO:0006614; GO:0008144; GO:0008312; GO:0016607; GO:0019003; GO:0030942; GO:0043021; GO:0044822 0 0 0 PF00448;PF02881;PF02978; P14618 CHOYP_KPYK.3.4 m.47446 sp KPYM_HUMAN 68.632 424 129 1 62 481 9 432 0 607 KPYM_HUMAN reviewed Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) PKM OIP3 PK2 PK3 PKM2 Homo sapiens (Human) 531 ATP biosynthetic process [GO:0006754]; canonical glycolysis [GO:0061621]; liver development [GO:0001889]; organ regeneration [GO:0031100]; programmed cell death [GO:0012501]; pyruvate biosynthetic process [GO:0042866]; response to gravity [GO:0009629]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to muscle inactivity [GO:0014870]; response to nutrient [GO:0007584]; skeletal muscle tissue regeneration [GO:0043403] GO:0000287; GO:0001666; GO:0001889; GO:0004743; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0005913; GO:0005929; GO:0006754; GO:0007584; GO:0009629; GO:0012501; GO:0014870; GO:0016301; GO:0023026; GO:0030955; GO:0031012; GO:0031100; GO:0031982; GO:0032868; GO:0042866; GO:0043209; GO:0043403; GO:0043531; GO:0044822; GO:0061621; GO:0070062; GO:0098641; GO:1903561 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. 0 0 PF00224;PF02887; P14618 CHOYP_KPYK.4.4 m.48513 sp KPYM_HUMAN 67.76 366 118 0 9 374 166 531 0 527 KPYM_HUMAN reviewed Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) PKM OIP3 PK2 PK3 PKM2 Homo sapiens (Human) 531 ATP biosynthetic process [GO:0006754]; canonical glycolysis [GO:0061621]; liver development [GO:0001889]; organ regeneration [GO:0031100]; programmed cell death [GO:0012501]; pyruvate biosynthetic process [GO:0042866]; response to gravity [GO:0009629]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to muscle inactivity [GO:0014870]; response to nutrient [GO:0007584]; skeletal muscle tissue regeneration [GO:0043403] GO:0000287; GO:0001666; GO:0001889; GO:0004743; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0005913; GO:0005929; GO:0006754; GO:0007584; GO:0009629; GO:0012501; GO:0014870; GO:0016301; GO:0023026; GO:0030955; GO:0031012; GO:0031100; GO:0031982; GO:0032868; GO:0042866; GO:0043209; GO:0043403; GO:0043531; GO:0044822; GO:0061621; GO:0070062; GO:0098641; GO:1903561 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. 0 0 PF00224;PF02887; P14618 CHOYP_KPYM.1.1 m.33498 sp KPYM_HUMAN 66.923 520 168 1 22 537 9 528 0 730 KPYM_HUMAN reviewed Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) PKM OIP3 PK2 PK3 PKM2 Homo sapiens (Human) 531 ATP biosynthetic process [GO:0006754]; canonical glycolysis [GO:0061621]; liver development [GO:0001889]; organ regeneration [GO:0031100]; programmed cell death [GO:0012501]; pyruvate biosynthetic process [GO:0042866]; response to gravity [GO:0009629]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to muscle inactivity [GO:0014870]; response to nutrient [GO:0007584]; skeletal muscle tissue regeneration [GO:0043403] GO:0000287; GO:0001666; GO:0001889; GO:0004743; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0005913; GO:0005929; GO:0006754; GO:0007584; GO:0009629; GO:0012501; GO:0014870; GO:0016301; GO:0023026; GO:0030955; GO:0031012; GO:0031100; GO:0031982; GO:0032868; GO:0042866; GO:0043209; GO:0043403; GO:0043531; GO:0044822; GO:0061621; GO:0070062; GO:0098641; GO:1903561 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. 0 0 PF00224;PF02887; P14685 CHOYP_LOC100375022.1.1 m.3033 sp PSMD3_MOUSE 64.6 500 174 2 6 503 32 530 0 629 PSMD3_MOUSE reviewed 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) (Transplantation antigen P91A) (Tum-P91A antigen) Psmd3 P91a Tstap91a Mus musculus (Mouse) 530 regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000502; GO:0005634; GO:0005654; GO:0005737; GO:0005838; GO:0006511; GO:0008541; GO:0016020; GO:0022624; GO:0030234; GO:0042176; GO:0070062 0 0 0 PF01399;PF08375; P14735 CHOYP_LOC101066029.1.1 m.64964 sp IDE_HUMAN 47.633 697 364 1 1 696 322 1018 0 679 IDE_HUMAN reviewed Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin) IDE Homo sapiens (Human) 1019 beta-amyloid metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; determination of adult lifespan [GO:0008340]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; insulin metabolic process [GO:1901142]; insulin receptor signaling pathway [GO:0008286]; negative regulation of proteolysis [GO:0045861]; positive regulation of protein oligomerization [GO:0032461]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; protein processing [GO:0016485]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; ubiquitin homeostasis [GO:0010992] GO:0001540; GO:0001618; GO:0001948; GO:0004222; GO:0005102; GO:0005524; GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005777; GO:0005782; GO:0005829; GO:0005886; GO:0006508; GO:0008270; GO:0008286; GO:0008340; GO:0009986; GO:0010815; GO:0010992; GO:0016485; GO:0016887; GO:0031597; GO:0031626; GO:0032461; GO:0042277; GO:0042447; GO:0042803; GO:0043130; GO:0043559; GO:0045861; GO:0050435; GO:0051260; GO:0051289; GO:0051291; GO:0051603; GO:1901142; GO:1901143 0 0 0 PF00675;PF05193;PF16187; P15056 CHOYP_BRAF.2.3 m.21192 sp BRAF_HUMAN 46.348 753 294 13 41 715 43 763 0 620 BRAF_HUMAN reviewed Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF BRAF1 RAFB1 Homo sapiens (Human) 766 "CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to drug [GO:0035690]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; glucose transport [GO:0015758]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; organ morphogenesis [GO:0009887]; positive regulation of axonogenesis [GO:0050772]; positive regulation of axon regeneration [GO:0048680]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive T cell selection [GO:0043368]; protein heterooligomerization [GO:0051291]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; response to cAMP [GO:0051591]; response to peptide hormone [GO:0043434]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; visual learning [GO:0008542]" GO:0000165; GO:0002318; GO:0004672; GO:0004674; GO:0004709; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006468; GO:0008542; GO:0009887; GO:0010628; GO:0010764; GO:0015758; GO:0030878; GO:0033138; GO:0035019; GO:0035690; GO:0042127; GO:0042802; GO:0043005; GO:0043066; GO:0043231; GO:0043367; GO:0043368; GO:0043434; GO:0043524; GO:0044297; GO:0048538; GO:0048680; GO:0050772; GO:0051291; GO:0051496; GO:0051591; GO:0060291; GO:0060323; GO:0060324; GO:0070374; GO:0071277; GO:0090150; GO:1900026; GO:2000301; GO:2000352 0 0 0 PF00130;PF07714;PF02196; P15056 CHOYP_BRAF.3.3 m.53371 sp BRAF_HUMAN 47.462 729 284 14 56 693 43 763 0 609 BRAF_HUMAN reviewed Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF BRAF1 RAFB1 Homo sapiens (Human) 766 "CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to drug [GO:0035690]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; glucose transport [GO:0015758]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; organ morphogenesis [GO:0009887]; positive regulation of axonogenesis [GO:0050772]; positive regulation of axon regeneration [GO:0048680]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive T cell selection [GO:0043368]; protein heterooligomerization [GO:0051291]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; response to cAMP [GO:0051591]; response to peptide hormone [GO:0043434]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; visual learning [GO:0008542]" GO:0000165; GO:0002318; GO:0004672; GO:0004674; GO:0004709; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006468; GO:0008542; GO:0009887; GO:0010628; GO:0010764; GO:0015758; GO:0030878; GO:0033138; GO:0035019; GO:0035690; GO:0042127; GO:0042802; GO:0043005; GO:0043066; GO:0043231; GO:0043367; GO:0043368; GO:0043434; GO:0043524; GO:0044297; GO:0048538; GO:0048680; GO:0050772; GO:0051291; GO:0051496; GO:0051591; GO:0060291; GO:0060323; GO:0060324; GO:0070374; GO:0071277; GO:0090150; GO:1900026; GO:2000301; GO:2000352 0 0 0 PF00130;PF07714;PF02196; P15215 CHOYP_PHUM_PHUM500930.1.1 m.21562 sp LAMC1_DROME 43.924 1621 875 14 28 1633 37 1638 0 1399 LAMC1_DROME reviewed Laminin subunit gamma-1 (Laminin B2 chain) LanB2 LAMC1 LAMG1 CG3322 Drosophila melanogaster (Fruit fly) 1639 basement membrane assembly [GO:0070831]; cell adhesion mediated by integrin [GO:0033627]; endodermal digestive tract morphogenesis [GO:0061031]; extracellular matrix assembly [GO:0085029]; midgut development [GO:0007494]; salivary gland morphogenesis [GO:0007435]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0005604; GO:0005605; GO:0007435; GO:0007494; GO:0012505; GO:0031012; GO:0033627; GO:0034446; GO:0061031; GO:0070831; GO:0085029 0 0 0 PF00052;PF00053;PF00055; P15253 CHOYP_LOC100083524.1.1 m.50023 sp CALR_RABIT 72.881 354 93 3 14 366 15 366 0 555 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P15253 CHOYP_LOC100533294.1.3 m.35108 sp CALR_RABIT 72.881 354 93 3 14 366 15 366 0 548 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P15253 CHOYP_LOC100533294.2.3 m.36820 sp CALR_RABIT 72.881 354 93 3 14 366 15 366 0 548 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P15253 CHOYP_LOC100533294.3.3 m.64946 sp CALR_RABIT 76.235 324 76 1 5 328 44 366 0 528 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P15253 CHOYP_SBP1.1.2 m.2084 sp CALR_RABIT 72.881 354 93 3 31 383 15 366 0 549 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P15389 CHOYP_SCN1.2.2 m.58068 sp SCN5A_RAT 40.149 2010 1004 47 54 1932 13 1954 0 1348 SCN5A_RAT reviewed Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) Scn5a Rattus norvegicus (Rat) 2019 AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell communication [GO:0086067]; brainstem development [GO:0003360]; bundle of His cell action potential [GO:0086043]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cellular response to calcium ion [GO:0071277]; cerebellum development [GO:0021549]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; membrane depolarization during SA node cell action potential [GO:0086046]; neuronal action potential [GO:0019228]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of action potential [GO:0045760]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of heart rate [GO:0010460]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0001518; GO:0002027; GO:0003360; GO:0005248; GO:0005783; GO:0005901; GO:0006814; GO:0010460; GO:0010765; GO:0014704; GO:0014894; GO:0016021; GO:0017134; GO:0019228; GO:0021537; GO:0021549; GO:0030018; GO:0030315; GO:0030506; GO:0035725; GO:0042475; GO:0045760; GO:0050679; GO:0051899; GO:0060048; GO:0060307; GO:0060371; GO:0060372; GO:0060373; GO:0071277; GO:0086002; GO:0086004; GO:0086005; GO:0086006; GO:0086010; GO:0086012; GO:0086015; GO:0086016; GO:0086043; GO:0086045; GO:0086046; GO:0086047; GO:0086048; GO:0086060; GO:0086061; GO:0086062; GO:0086063; GO:0086067; GO:0086091; GO:1902305 0 0 0 PF00520;PF06512;PF11933; P15390 CHOYP_SCN1.1.2 m.28878 sp SCN4A_RAT 42.549 1852 894 38 54 1831 17 1772 0 1347 SCN4A_RAT reviewed Sodium channel protein type 4 subunit alpha (Mu-1) (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) Scn4a Rattus norvegicus (Rat) 1840 cation transport [GO:0006812]; choline transport [GO:0015871]; membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] GO:0001518; GO:0005248; GO:0005886; GO:0006812; GO:0006813; GO:0006814; GO:0015871; GO:0019228; GO:0086010 0 0 0 PF00520;PF06512; P15651 CHOYP_NEMVEDRAFT_V1G179716.1.1 m.55972 sp ACADS_RAT 70.455 396 117 0 28 423 17 412 0 601 ACADS_RAT reviewed "Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)" Acads Rattus norvegicus (Rat) 412 butyrate catabolic process [GO:0046359]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088]; protein homotetramerization [GO:0051289]; response to glucocorticoid [GO:0051384]; response to starvation [GO:0042594] GO:0000062; GO:0003995; GO:0004085; GO:0005739; GO:0005759; GO:0006635; GO:0009055; GO:0031966; GO:0033539; GO:0042594; GO:0046359; GO:0050660; GO:0051289; GO:0051384; GO:0055088 PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. 0 0 PF00441;PF02770;PF02771; P15848 CHOYP_LOC100377677.1.2 m.23471 sp ARSB_HUMAN 53.32 497 208 7 22 497 40 533 0 544 ARSB_HUMAN reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) ARSB Homo sapiens (Human) 533 autophagy [GO:0006914]; central nervous system development [GO:0007417]; chondroitin sulfate catabolic process [GO:0030207]; colon epithelial cell migration [GO:0061580]; glycosphingolipid metabolic process [GO:0006687]; lysosomal transport [GO:0007041]; lysosome organization [GO:0007040]; positive regulation of neuron projection development [GO:0010976]; post-translational protein modification [GO:0043687]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005788; GO:0005791; GO:0005794; GO:0006687; GO:0006914; GO:0007040; GO:0007041; GO:0007417; GO:0007584; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0030207; GO:0043202; GO:0043627; GO:0043687; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; P16066 CHOYP_GCY.1.4 m.1437 sp ANPRA_HUMAN 41.846 791 412 17 24 794 33 795 0 607 ANPRA_HUMAN reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) NPR1 ANPRA Homo sapiens (Human) 1061 body fluid secretion [GO:0007589]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of vascular permeability [GO:0043114]; regulation of vasodilation [GO:0042312] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007166; GO:0007168; GO:0007589; GO:0008074; GO:0008217; GO:0008528; GO:0016525; GO:0016941; GO:0017046; GO:0030308; GO:0030828; GO:0035556; GO:0035810; GO:0035815; GO:0042312; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1903779 0 0 0 PF01094;PF00211;PF07714; P16435 CHOYP_LOC594665.1.1 m.8448 sp NCPR_HUMAN 62.76 674 247 2 1 672 6 677 0 927 NCPR_HUMAN reviewed NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4) POR CYPOR Homo sapiens (Human) 677 carnitine metabolic process [GO:0009437]; cellular organofluorine metabolic process [GO:0090346]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to peptide hormone stimulus [GO:0071375]; demethylation [GO:0070988]; fatty acid oxidation [GO:0019395]; flavonoid metabolic process [GO:0009812]; internal peptidyl-lysine acetylation [GO:0018393]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of lipase activity [GO:0060192]; nitrate catabolic process [GO:0043602]; nitric oxide catabolic process [GO:0046210]; oxidation-reduction process [GO:0055114]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of monooxygenase activity [GO:0032770]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of steroid hormone biosynthetic process [GO:0090031]; regulation of growth plate cartilage chondrocyte proliferation [GO:0003420]; response to drug [GO:0042493]; response to nutrient [GO:0007584]; xenobiotic metabolic process [GO:0006805] GO:0003420; GO:0003958; GO:0004128; GO:0005739; GO:0005789; GO:0006805; GO:0007584; GO:0008941; GO:0009055; GO:0009437; GO:0009812; GO:0010181; GO:0016020; GO:0016021; GO:0016787; GO:0018393; GO:0019395; GO:0030586; GO:0032332; GO:0032770; GO:0042493; GO:0043154; GO:0043231; GO:0043602; GO:0045542; GO:0045880; GO:0046210; GO:0047726; GO:0050660; GO:0050661; GO:0055114; GO:0060192; GO:0070988; GO:0071372; GO:0071375; GO:0090031; GO:0090346 0 0 0 PF00667;PF00258;PF00175; P16591 CHOYP_LOC100119086.1.1 m.55425 sp FER_HUMAN 39.14 884 453 18 1 862 1 821 0 592 FER_HUMAN reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) FER TYK3 Homo sapiens (Human) 822 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cellular response to insulin stimulus [GO:0032869]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; substrate adhesion-dependent cell spreading [GO:0034446]; tyrosine phosphorylation of Stat3 protein [GO:0042503] GO:0000226; GO:0000278; GO:0001932; GO:0004713; GO:0004715; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005938; GO:0006468; GO:0006935; GO:0007155; GO:0008283; GO:0008284; GO:0008289; GO:0010591; GO:0010762; GO:0018108; GO:0019221; GO:0030054; GO:0030154; GO:0030335; GO:0030838; GO:0031234; GO:0031532; GO:0032496; GO:0032869; GO:0033007; GO:0034446; GO:0034614; GO:0035426; GO:0035556; GO:0036006; GO:0036119; GO:0038028; GO:0038083; GO:0038095; GO:0038109; GO:0042058; GO:0042503; GO:0042995; GO:0043304; GO:0044331; GO:0045087; GO:0046777; GO:0048008; GO:0050904; GO:0051092; GO:0070102 0 0 0 PF00611;PF07714;PF00017; P16621 CHOYP_PTPRF.3.6 m.28841 sp LAR_DROME 44.002 1959 976 39 26 1934 140 2027 0 1537 LAR_DROME reviewed Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR) Lar CG10443 Drosophila melanogaster (Fruit fly) 2029 axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; embryonic development via the syncytial blastoderm [GO:0001700]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; protein dephosphorylation [GO:0006470]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell shape [GO:0008360]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic growth at neuromuscular junction [GO:0051124] GO:0001700; GO:0004725; GO:0005001; GO:0005875; GO:0005886; GO:0005925; GO:0006470; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008360; GO:0008594; GO:0016021; GO:0030424; GO:0031290; GO:0032093; GO:0045467; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:1903386 0 0 0 PF00041;PF07679;PF00102; P17126 CHOYP_ACTC.3.6 m.21571 sp ACT_HYDVU 90.625 352 8 1 1 352 1 327 0 654 ACT_HYDVU reviewed "Actin, non-muscle 6.2" 0 Hydra vulgaris (Hydra) (Hydra attenuata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P17139 CHOYP_CBR-LET-2.2.2 m.44681 sp CO4A1_CAEEL 48.585 1696 802 22 3 1668 103 1758 0 978 CO4A1_CAEEL reviewed Collagen alpha-1(IV) chain emb-9 clb-2 K04H4.1 Caenorhabditis elegans 1759 embryo development ending in birth or egg hatching [GO:0009792]; extracellular matrix organization [GO:0030198]; muscle organ development [GO:0007517]; nematode larval development [GO:0002119]; positive regulation of protein secretion [GO:0050714] GO:0002119; GO:0005201; GO:0005581; GO:0005604; GO:0007517; GO:0009792; GO:0030198; GO:0050714 0 0 0 PF01413;PF01391; P17140 CHOYP_CBR-LET-2.1.2 m.37495 sp CO4A2_CAEEL 49.786 1870 682 42 50 1799 22 1754 0 942 CO4A2_CAEEL reviewed Collagen alpha-2(IV) chain (Lethal protein 2) let-2 clb-1 F01G12.5 Caenorhabditis elegans 1758 cellular component organization [GO:0016043]; embryo development ending in birth or egg hatching [GO:0009792] GO:0005198; GO:0005587; GO:0005604; GO:0009792; GO:0016043; GO:0030020 0 0 0 PF01413;PF01391; P17248 CHOYP_SYWC.4.5 m.36166 sp SYWC_BOVIN 72.139 402 111 1 71 472 75 475 0 619 SYWC_BOVIN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS Bos taurus (Bovine) 476 regulation of angiogenesis [GO:0045765]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0006436; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P17248 CHOYP_SYWC.5.5 m.54888 sp SYWC_BOVIN 72.519 393 107 1 9 401 75 466 0 610 SYWC_BOVIN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS Bos taurus (Bovine) 476 regulation of angiogenesis [GO:0045765]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0006436; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P17276 CHOYP_BRAFLDRAFT_115951.1.1 m.22622 sp PH4H_DROME 64.649 413 138 3 50 462 46 450 0 566 PH4H_DROME reviewed Protein henna (EC 1.14.16.1) (EC 1.14.16.4) (Phe-4-monooxygenase) (Phenylalanine-4-hydroxylase) (PAH) (Tryptophan 5-hydroxylase) (TRH) (Tryptophan 5-monooxygenase) Hn pah Tph CG7399 Drosophila melanogaster (Fruit fly) 452 aromatic amino acid family metabolic process [GO:0009072]; eye pigment biosynthetic process [GO:0006726]; long-term memory [GO:0007616]; L-phenylalanine catabolic process [GO:0006559]; phagocytosis [GO:0006909]; serotonin biosynthetic process [GO:0042427] GO:0004505; GO:0004510; GO:0005506; GO:0005811; GO:0006559; GO:0006726; GO:0006909; GO:0007616; GO:0009072; GO:0016597; GO:0042427 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. 0 0 PF00351; P17427 CHOYP_AP2A2.1.1 m.62726 sp AP2A2_MOUSE 71.399 965 241 10 1 957 1 938 0 1391 AP2A2_MOUSE reviewed AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) Ap2a2 Adtab Mus musculus (Mouse) 938 endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; regulation of hematopoietic stem cell differentiation [GO:1902036]; vesicle-mediated transport [GO:0016192] GO:0005886; GO:0005905; GO:0006886; GO:0006897; GO:0008289; GO:0008565; GO:0016023; GO:0016192; GO:0019901; GO:0030117; GO:0030131; GO:0030141; GO:1902036 0 0 0 PF01602;PF02296;PF02883; P17439 CHOYP_GLCM.3.3 m.63506 sp GLCM_MOUSE 51.697 501 231 7 46 542 19 512 0 523 GLCM_MOUSE reviewed Glucosylceramidase (EC 3.2.1.45) (Acid beta-glucosidase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) Gba Mus musculus (Mouse) 515 carbohydrate metabolic process [GO:0005975]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; glucosylceramide catabolic process [GO:0006680]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAP kinase activity [GO:0043407]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of proteolysis involved in cellular protein catabolic process [GO:1903052]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of water loss via skin [GO:0033561]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to pH [GO:0009268]; response to testosterone [GO:0033574]; response to thyroid hormone [GO:0097066]; skin morphogenesis [GO:0043589]; sphingosine biosynthetic process [GO:0046512]; termination of signal transduction [GO:0023021] GO:0004348; GO:0005102; GO:0005615; GO:0005765; GO:0005975; GO:0006680; GO:0009267; GO:0009268; GO:0016239; GO:0016787; GO:0023021; GO:0032434; GO:0032715; GO:0033561; GO:0033574; GO:0035307; GO:0043202; GO:0043407; GO:0043589; GO:0043627; GO:0046512; GO:0046513; GO:0051384; GO:0070062; GO:0071356; GO:0097066; GO:1903052 0 0 0 PF02055;PF17189; P17970 CHOYP_SHAB.1.1 m.18570 sp KCNAB_DROME 71.304 460 127 3 104 559 259 717 0 721 KCNAB_DROME reviewed Potassium voltage-gated channel protein Shab Shab CG43128 Drosophila melanogaster (Fruit fly) 985 action potential [GO:0001508]; chemical synaptic transmission [GO:0007268]; larval locomotory behavior [GO:0008345]; neuron projection morphogenesis [GO:0048812]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; regulation of heart contraction [GO:0008016]; regulation of synaptic activity [GO:0060025] GO:0001508; GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0007268; GO:0008016; GO:0008076; GO:0008345; GO:0048812; GO:0051260; GO:0060025 0 0 0 PF02214;PF00520; P17971 CHOYP_KCNAL.1.2 m.214 sp KCNAL_DROME 79.226 491 98 3 1 487 1 491 0 813 KCNAL_DROME reviewed Potassium voltage-gated channel protein Shal (Shaker cognate l) (Shal2) Shal SHAL2 CG9262 Drosophila melanogaster (Fruit fly) 571 associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] GO:0005249; GO:0005250; GO:0005886; GO:0006813; GO:0007268; GO:0008076; GO:0008306; GO:0030425; GO:0043204; GO:0051260 0 0 0 PF02214;PF11879;PF00520;PF11601; P17971 CHOYP_KCNAL.2.2 m.32123 sp KCNAL_DROME 73.656 558 139 5 25 574 1 558 0 848 KCNAL_DROME reviewed Potassium voltage-gated channel protein Shal (Shaker cognate l) (Shal2) Shal SHAL2 CG9262 Drosophila melanogaster (Fruit fly) 571 associative learning [GO:0008306]; chemical synaptic transmission [GO:0007268]; potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] GO:0005249; GO:0005250; GO:0005886; GO:0006813; GO:0007268; GO:0008076; GO:0008306; GO:0030425; GO:0043204; GO:0051260 0 0 0 PF02214;PF11879;PF00520;PF11601; P17972 CHOYP_LOC100533319.1.2 m.46 sp KCNAW_DROME 76.754 456 95 3 6 450 9 464 0 723 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P17972 CHOYP_LOC100533319.2.2 m.8432 sp KCNAW_DROME 76.754 456 95 3 6 450 9 464 0 726 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P18091 CHOYP_ACTN.1.2 m.15252 sp ACTN_DROME 74.777 896 189 4 72 934 33 924 0 1405 ACTN_DROME reviewed "Alpha-actinin, sarcomeric (F-actin cross-linking protein)" Actn fliA l(1)2Cb CG4376 Drosophila melanogaster (Fruit fly) 924 actin cytoskeleton reorganization [GO:0031532]; cytoskeletal anchoring at plasma membrane [GO:0007016]; flight behavior [GO:0007629]; sarcomere organization [GO:0045214] GO:0003779; GO:0005509; GO:0005925; GO:0007016; GO:0007629; GO:0030018; GO:0031532; GO:0045214 0 0 0 PF00307;PF13405;PF08726;PF00435; P18293 CHOYP_GCY.2.4 m.33243 sp ANPRA_MOUSE 48.547 1032 488 17 38 1052 46 1051 0 953 ANPRA_MOUSE reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Npra Mus musculus (Mouse) 1057 cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood vessel size [GO:0050880] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0006182; GO:0007168; GO:0008074; GO:0016021; GO:0016941; GO:0017046; GO:0030828; GO:0035556; GO:0042417; GO:0042562; GO:0043235; GO:0048662; GO:0050880 0 0 0 PF01094;PF00211;PF07714; P18293 CHOYP_GCY.3.4 m.40473 sp ANPRA_MOUSE 47.913 1054 495 17 38 1069 30 1051 0 956 ANPRA_MOUSE reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Npra Mus musculus (Mouse) 1057 cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood vessel size [GO:0050880] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0006182; GO:0007168; GO:0008074; GO:0016021; GO:0016941; GO:0017046; GO:0030828; GO:0035556; GO:0042417; GO:0042562; GO:0043235; GO:0048662; GO:0050880 0 0 0 PF01094;PF00211;PF07714; P18293 CHOYP_GCY.4.4 m.41003 sp ANPRA_MOUSE 48.716 1051 492 17 38 1070 30 1051 0 991 ANPRA_MOUSE reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Npra Mus musculus (Mouse) 1057 cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood vessel size [GO:0050880] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0006182; GO:0007168; GO:0008074; GO:0016021; GO:0016941; GO:0017046; GO:0030828; GO:0035556; GO:0042417; GO:0042562; GO:0043235; GO:0048662; GO:0050880 0 0 0 PF01094;PF00211;PF07714; P18293 CHOYP_LOC100373545.1.1 m.48477 sp ANPRA_MOUSE 39.589 778 439 17 1 766 290 1048 0 552 ANPRA_MOUSE reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Npra Mus musculus (Mouse) 1057 cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood vessel size [GO:0050880] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0006182; GO:0007168; GO:0008074; GO:0016021; GO:0016941; GO:0017046; GO:0030828; GO:0035556; GO:0042417; GO:0042562; GO:0043235; GO:0048662; GO:0050880 0 0 0 PF01094;PF00211;PF07714; P18293 CHOYP_LOC726069.1.1 m.64327 sp ANPRA_MOUSE 49.949 983 448 18 6 972 97 1051 0 941 ANPRA_MOUSE reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Npra Mus musculus (Mouse) 1057 cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood vessel size [GO:0050880] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0006182; GO:0007168; GO:0008074; GO:0016021; GO:0016941; GO:0017046; GO:0030828; GO:0035556; GO:0042417; GO:0042562; GO:0043235; GO:0048662; GO:0050880 0 0 0 PF01094;PF00211;PF07714; P18700 CHOYP_LOC100366728.1.1 m.57452 sp TBB_STRPU 96.85 254 8 0 11 264 38 291 0 520 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P19208 CHOYP_LOC100200137.1.1 m.23041 sp HSP7C_CAEBR 81.027 448 81 2 1 448 218 661 0 740 HSP7C_CAEBR reviewed Heat shock 70 kDa protein C hsp-3 CBG14829 Caenorhabditis briggsae 661 0 GO:0005524; GO:0005788 0 0 0 PF00012; P19468 CHOYP_GSH1.1.1 m.8927 sp GSH1_RAT 61.836 621 215 11 1 615 1 605 0 785 GSH1_RAT reviewed Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) Gclc Glclc Rattus norvegicus (Rat) 637 "aging [GO:0007568]; apoptotic mitochondrial changes [GO:0008637]; cell redox homeostasis [GO:0045454]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to insulin stimulus [GO:0032869]; cellular response to mechanical stimulus [GO:0071260]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of hepatic stellate cell activation [GO:2000490]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of blood vessel size [GO:0050880]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to arsenic-containing substance [GO:0046685]; response to cadmium ion [GO:0046686]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to human chorionic gonadotropin [GO:0044752]; response to interleukin-1 [GO:0070555]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; response to xenobiotic stimulus [GO:0009410]" GO:0000287; GO:0004357; GO:0005524; GO:0005829; GO:0006534; GO:0006536; GO:0006750; GO:0006979; GO:0007568; GO:0007584; GO:0008637; GO:0009408; GO:0009410; GO:0009725; GO:0014823; GO:0016595; GO:0017109; GO:0019852; GO:0031397; GO:0032436; GO:0032869; GO:0035729; GO:0043066; GO:0043524; GO:0043531; GO:0044344; GO:0044752; GO:0045454; GO:0045892; GO:0046685; GO:0046686; GO:0046982; GO:0050662; GO:0050880; GO:0051409; GO:0051900; GO:0070555; GO:0071260; GO:0071333; GO:0071372; GO:0097069; GO:2000490; GO:2001237 PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. 0 0 PF03074; P19891 CHOYP_LOC100369657.2.2 m.45309 sp ASNS_CRIGR 57.961 559 224 4 1 550 1 557 0 694 ASNS_CRIGR reviewed Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Glutamine-dependent asparagine synthetase) ASNS AS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 561 glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981] GO:0004066; GO:0005524; GO:0006541; GO:0070981 PATHWAY: Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1. 0 cd01991;cd00712; PF00733;PF13537; P20000 CHOYP_ALDH2.3.3 m.25044 sp ALDH2_BOVIN 71.888 498 140 0 22 519 23 520 0 778 ALDH2_BOVIN reviewed "Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)" ALDH2 Bos taurus (Bovine) 520 ethanol catabolic process [GO:0006068] GO:0004029; GO:0005759; GO:0006068 PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. 0 0 PF00171; P20241 CHOYP_NRG.1.1 m.10622 sp NRG_DROME 33.938 1158 692 23 68 1197 26 1138 0 592 NRG_DROME reviewed Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) 1302 "axon ensheathment [GO:0008366]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell adhesion involved in heart morphogenesis [GO:0061343]; central complex development [GO:0048036]; dendrite morphogenesis [GO:0048813]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of glial blood-brain barrier [GO:0060857]; female courtship behavior [GO:0008050]; imaginal disc morphogenesis [GO:0007560]; male courtship behavior [GO:0008049]; melanotic encapsulation of foreign target [GO:0035011]; motor neuron axon guidance [GO:0008045]; mushroom body development [GO:0016319]; nerve maturation [GO:0021682]; neuron cell-cell adhesion [GO:0007158]; neuron projection morphogenesis [GO:0048812]; photoreceptor cell axon guidance [GO:0072499]; regulation of female receptivity [GO:0045924]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; synapse organization [GO:0050808]" GO:0005509; GO:0005886; GO:0005918; GO:0005919; GO:0005923; GO:0007158; GO:0007173; GO:0007409; GO:0007560; GO:0008045; GO:0008049; GO:0008050; GO:0008366; GO:0016021; GO:0016319; GO:0016328; GO:0019991; GO:0021682; GO:0030175; GO:0035011; GO:0035151; GO:0045924; GO:0048036; GO:0048675; GO:0048812; GO:0048813; GO:0050808; GO:0060857; GO:0061343; GO:0072499 0 0 0 PF13882;PF00041;PF07679;PF00047; P20478 CHOYP_BRAFLDRAFT_283789.1.1 m.40988 sp GLNA2_DROME 72.958 355 95 1 7 361 16 369 0 566 GLNA2_DROME reviewed Glutamine synthetase 2 cytoplasmic (EC 6.3.1.2) (Glutamate--ammonia ligase 2) Gs2 CG1743 Drosophila melanogaster (Fruit fly) 369 glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; neurotransmitter receptor metabolic process [GO:0045213]; synapse assembly [GO:0007416] GO:0004356; GO:0005524; GO:0005737; GO:0006538; GO:0006542; GO:0007416; GO:0045213 0 0 0 PF00120;PF03951; P20478 CHOYP_GLNA2.1.4 m.4133 sp GLNA2_DROME 73.446 354 94 0 7 360 16 369 0 573 GLNA2_DROME reviewed Glutamine synthetase 2 cytoplasmic (EC 6.3.1.2) (Glutamate--ammonia ligase 2) Gs2 CG1743 Drosophila melanogaster (Fruit fly) 369 glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; neurotransmitter receptor metabolic process [GO:0045213]; synapse assembly [GO:0007416] GO:0004356; GO:0005524; GO:0005737; GO:0006538; GO:0006542; GO:0007416; GO:0045213 0 0 0 PF00120;PF03951; P20585 CHOYP_MSH3.1.2 m.14117 sp MSH3_HUMAN 51.765 935 426 11 187 1102 198 1126 0 937 MSH3_HUMAN reviewed DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) MSH3 DUC1 DUG Homo sapiens (Human) 1137 DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; meiotic mismatch repair [GO:0000710]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; reciprocal meiotic recombination [GO:0007131] GO:0000228; GO:0000710; GO:0003684; GO:0005524; GO:0005654; GO:0006281; GO:0006298; GO:0007131; GO:0016020; GO:0019899; GO:0030983; GO:0032302; GO:0043570; GO:0045910; GO:0051096 0 0 0 PF01624;PF05188;PF05192;PF00488; P20594 CHOYP_ANPRB.2.2 m.36017 sp ANPRB_HUMAN 39.65 971 498 25 87 996 96 1039 0 625 ANPRB_HUMAN reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 ANPRB Homo sapiens (Human) 1047 bone development [GO:0060348]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; single organism reproductive process [GO:0044702] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007168; GO:0008074; GO:0008217; GO:0016941; GO:0017046; GO:0035556; GO:0042562; GO:0044702; GO:0051447; GO:0060348; GO:0097011; GO:1900194; GO:1903779 0 0 0 PF01094;PF00211;PF07714; P20595 CHOYP_BRAFLDRAFT_56822.1.1 m.27095 sp GCYB1_RAT 62.866 614 224 3 1 612 1 612 0 815 GCYB1_RAT reviewed Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) Gucy1b3 Guc1b3 Gucy1b1 Rattus norvegicus (Rat) 619 cAMP biosynthetic process [GO:0006171]; cellular response to nitric oxide [GO:0071732]; cGMP biosynthetic process [GO:0006182]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060]; nitric oxide mediated signal transduction [GO:0007263] GO:0004383; GO:0005525; GO:0005829; GO:0005886; GO:0006171; GO:0006182; GO:0007263; GO:0008074; GO:0020037; GO:0038060; GO:0043167; GO:0043231; GO:0043234; GO:0046872; GO:0046982; GO:0051879; GO:0071732 0 0 0 PF00211;PF07700;PF07701; P20742 CHOYP_A2M.2.3 m.54214 sp PZP_HUMAN 36.583 995 542 25 1167 2108 511 1469 0 599 PZP_HUMAN reviewed Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) PZP CPAMD6 Homo sapiens (Human) 1482 female pregnancy [GO:0007565] GO:0004866; GO:0004867; GO:0005576; GO:0007565; GO:0070062; GO:0072562 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; P20742 CHOYP_A2M.3.3 m.58410 sp PZP_HUMAN 36.482 995 543 25 1018 1959 511 1469 0 599 PZP_HUMAN reviewed Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) PZP CPAMD6 Homo sapiens (Human) 1482 female pregnancy [GO:0007565] GO:0004866; GO:0004867; GO:0005576; GO:0007565; GO:0070062; GO:0072562 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; P20742 CHOYP_LOC101439509.1.1 m.65851 sp PZP_HUMAN 36.683 995 541 25 1102 2043 511 1469 0 597 PZP_HUMAN reviewed Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6) PZP CPAMD6 Homo sapiens (Human) 1482 female pregnancy [GO:0007565] GO:0004866; GO:0004867; GO:0005576; GO:0007565; GO:0070062; GO:0072562 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; P20936 CHOYP_LOC100875369.1.1 m.31446 sp RASA1_HUMAN 47.386 918 445 14 33 940 151 1040 0 832 RASA1_HUMAN reviewed Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) RASA1 GAP RASA Homo sapiens (Human) 1047 blood vessel morphogenesis [GO:0048514]; embryo development [GO:0009790]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; mitotic cytokinesis [GO:0000281]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of Ras protein signal transduction [GO:0046580]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of RNA metabolic process [GO:0051252]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] GO:0000165; GO:0000281; GO:0001570; GO:0001726; GO:0001948; GO:0001953; GO:0005096; GO:0005102; GO:0005737; GO:0005829; GO:0007162; GO:0007165; GO:0008360; GO:0009790; GO:0019870; GO:0030833; GO:0031235; GO:0035556; GO:0043524; GO:0046580; GO:0048013; GO:0048514; GO:0051020; GO:0051252 0 0 0 PF00168;PF00169;PF00616;PF00017;PF00018; P21127 CHOYP_CD11B.1.1 m.51509 sp CD11B_HUMAN 77.468 395 83 3 438 831 406 795 0 659 CD11B_HUMAN reviewed Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1) CDK11B CDC2L1 CDK11 PITSLREA PK58 Homo sapiens (Human) 795 "apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; mitotic nuclear division [GO:0007067]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of mRNA processing [GO:0050684]; regulation of transcription, DNA-templated [GO:0006355]" GO:0001558; GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0006355; GO:0006468; GO:0006915; GO:0007067; GO:0008283; GO:0044822; GO:0050684 0 0 0 PF00069; P21213 CHOYP_HUTH.1.1 m.30350 sp HUTH_RAT 67.597 645 201 4 34 674 3 643 0 890 HUTH_RAT reviewed Histidine ammonia-lyase (Histidase) (EC 4.3.1.3) Hal Huth Rattus norvegicus (Rat) 657 histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]; histidine metabolic process [GO:0006547] GO:0004397; GO:0005829; GO:0006547; GO:0019556; GO:0019557 PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3. 0 cd00332; PF12053;PF00221; P21265 CHOYP_PUR8.1.1 m.2748 sp PUR8_CHICK 76.421 475 110 1 13 487 13 485 0 771 PUR8_CHICK reviewed Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase) ADSL Gallus gallus (Chicken) 485 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; protein tetramerization [GO:0051262]; purine nucleotide metabolic process [GO:0006163] GO:0004018; GO:0005829; GO:0006163; GO:0006189; GO:0044208; GO:0051262; GO:0070626 PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2. 0 0 PF10397;PF00206; P21333 CHOYP_FLNB.1.1 m.55733 sp FLNA_HUMAN 49.468 1599 760 15 14 1584 1068 2646 0 1486 FLNA_HUMAN reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; cell junction assembly [GO:0034329]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; establishment of protein localization [GO:0045184]; mitotic spindle assembly [GO:0090307]; mRNA transcription from RNA polymerase II promoter [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001664; GO:0001948; GO:0002576; GO:0004871; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005911; GO:0005913; GO:0005925; GO:0007195; GO:0008134; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030168; GO:0030334; GO:0030863; GO:0031012; GO:0031267; GO:0031523; GO:0031532; GO:0034329; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042789; GO:0042803; GO:0042993; GO:0043025; GO:0043066; GO:0043113; GO:0043123; GO:0043198; GO:0043433; GO:0044319; GO:0044822; GO:0045184; GO:0048365; GO:0048471; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:0097440; GO:0098641; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; P21333 CHOYP_FLNC.2.5 m.37450 sp FLNA_HUMAN 43.804 2413 1251 41 559 2905 273 2646 0 1793 FLNA_HUMAN reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; cell junction assembly [GO:0034329]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; establishment of protein localization [GO:0045184]; mitotic spindle assembly [GO:0090307]; mRNA transcription from RNA polymerase II promoter [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001664; GO:0001948; GO:0002576; GO:0004871; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005911; GO:0005913; GO:0005925; GO:0007195; GO:0008134; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030168; GO:0030334; GO:0030863; GO:0031012; GO:0031267; GO:0031523; GO:0031532; GO:0034329; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042789; GO:0042803; GO:0042993; GO:0043025; GO:0043066; GO:0043113; GO:0043123; GO:0043198; GO:0043433; GO:0044319; GO:0044822; GO:0045184; GO:0048365; GO:0048471; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:0097440; GO:0098641; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; P21333 CHOYP_FLNC.3.5 m.38669 sp FLNA_HUMAN 43.804 2413 1251 41 582 2928 273 2646 0 1793 FLNA_HUMAN reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; cell junction assembly [GO:0034329]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; establishment of protein localization [GO:0045184]; mitotic spindle assembly [GO:0090307]; mRNA transcription from RNA polymerase II promoter [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001664; GO:0001948; GO:0002576; GO:0004871; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005911; GO:0005913; GO:0005925; GO:0007195; GO:0008134; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030168; GO:0030334; GO:0030863; GO:0031012; GO:0031267; GO:0031523; GO:0031532; GO:0034329; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042789; GO:0042803; GO:0042993; GO:0043025; GO:0043066; GO:0043113; GO:0043123; GO:0043198; GO:0043433; GO:0044319; GO:0044822; GO:0045184; GO:0048365; GO:0048471; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:0097440; GO:0098641; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; P21399 CHOYP_ACO1.1.1 m.40517 sp ACOC_HUMAN 68.201 934 249 1 7 940 2 887 0 1348 ACOC_HUMAN reviewed Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) ACO1 IREB1 Homo sapiens (Human) 889 cellular iron ion homeostasis [GO:0006879]; citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; post-embryonic development [GO:0009791]; regulation of translation [GO:0006417]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099] GO:0003723; GO:0003994; GO:0005737; GO:0005739; GO:0005783; GO:0005794; GO:0005829; GO:0006099; GO:0006101; GO:0006417; GO:0006879; GO:0009791; GO:0010040; GO:0030350; GO:0046872; GO:0050892; GO:0051539; GO:0070062 0 0 0 PF00330;PF00694; P21399 CHOYP_contig_005583 m.6332 sp ACOC_HUMAN 72.122 886 247 0 23 908 2 887 0 1377 ACOC_HUMAN reviewed Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) ACO1 IREB1 Homo sapiens (Human) 889 cellular iron ion homeostasis [GO:0006879]; citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; post-embryonic development [GO:0009791]; regulation of translation [GO:0006417]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099] GO:0003723; GO:0003994; GO:0005737; GO:0005739; GO:0005783; GO:0005794; GO:0005829; GO:0006099; GO:0006101; GO:0006417; GO:0006879; GO:0009791; GO:0010040; GO:0030350; GO:0046872; GO:0050892; GO:0051539; GO:0070062 0 0 0 PF00330;PF00694; P21440 CHOYP_MDR1B.1.2 m.12480 sp MDR3_MOUSE 49.921 1264 599 11 70 1325 29 1266 0 1236 MDR3_MOUSE reviewed Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 2) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 2) (P-glycoprotein 3) Abcb4 Mdr2 Pgy-2 Pgy2 Mus musculus (Mouse) 1276 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; phospholipid translocation [GO:0045332]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to fenofibrate [GO:1901557]" GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005524; GO:0005737; GO:0005886; GO:0008525; GO:0016020; GO:0016021; GO:0016324; GO:0030136; GO:0032376; GO:0032782; GO:0042626; GO:0045121; GO:0045332; GO:0046581; GO:0055088; GO:0061092; GO:0070062; GO:0090554; GO:1901557; GO:1903413; GO:2001140 0 0 0 PF00664;PF00005; P21440 CHOYP_MDR3.2.3 m.33550 sp MDR3_MOUSE 52.502 1019 438 9 3 1016 289 1266 0 1066 MDR3_MOUSE reviewed Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 2) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 2) (P-glycoprotein 3) Abcb4 Mdr2 Pgy-2 Pgy2 Mus musculus (Mouse) 1276 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; phospholipid translocation [GO:0045332]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to fenofibrate [GO:1901557]" GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005524; GO:0005737; GO:0005886; GO:0008525; GO:0016020; GO:0016021; GO:0016324; GO:0030136; GO:0032376; GO:0032782; GO:0042626; GO:0045121; GO:0045332; GO:0046581; GO:0055088; GO:0061092; GO:0070062; GO:0090554; GO:1901557; GO:1903413; GO:2001140 0 0 0 PF00664;PF00005; P21575 CHOYP_DYN1.2.3 m.30771 sp DYN1_RAT 68.655 855 224 10 27 843 2 850 0 1181 DYN1_RAT reviewed "Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin, brain)" Dnm1 Dnm Rattus norvegicus (Rat) 864 "adult locomotory behavior [GO:0008344]; clathrin-mediated endocytosis [GO:0072583]; endosome organization [GO:0007032]; G-protein coupled receptor internalization [GO:0002031]; positive regulation of synaptic vesicle recycling [GO:1903423]; protein tetramerization [GO:0051262]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; sensory perception of sound [GO:0007605]; synaptic transmission, GABAergic [GO:0051932]; toxin transport [GO:1901998]" GO:0001917; GO:0002031; GO:0003924; GO:0005525; GO:0005737; GO:0005794; GO:0005874; GO:0005886; GO:0006898; GO:0007032; GO:0007605; GO:0008021; GO:0008022; GO:0008344; GO:0030117; GO:0031623; GO:0031749; GO:0032403; GO:0042802; GO:0043196; GO:0043209; GO:0043234; GO:0044822; GO:0045202; GO:0050998; GO:0051262; GO:0051932; GO:0070062; GO:0072583; GO:1901998; GO:1903423 0 0 0 PF01031;PF00350;PF02212;PF00169; P21613 CHOYP_KINH.1.9 m.1032 sp KINH_DORPE 72.622 946 235 5 5 944 4 931 0 1399 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P21613 CHOYP_KINH.7.9 m.42396 sp KINH_DORPE 72.093 946 240 5 5 944 4 931 0 1382 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P21675 CHOYP_TAF1.1.1 m.31656 sp TAF1_HUMAN 53.021 1837 697 29 3 1786 22 1745 0 1696 TAF1_HUMAN reviewed Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) TAF1 BA2R CCG1 CCGS TAF2A Homo sapiens (Human) 1872 "cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; DNA-templated transcription, initiation [GO:0006352]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; protein autophosphorylation [GO:0046777]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II transcriptional preinitiation complex assembly [GO:0051123]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]" GO:0002039; GO:0003713; GO:0004402; GO:0004674; GO:0005524; GO:0005654; GO:0005669; GO:0006352; GO:0006366; GO:0006367; GO:0006368; GO:0006974; GO:0007049; GO:0008134; GO:0016032; GO:0017025; GO:0018105; GO:0018107; GO:0032436; GO:0043565; GO:0045944; GO:0046777; GO:0051123; GO:0060261; GO:0070577; GO:0071339; GO:1901796 0 0 0 PF00439;PF12157;PF09247; P21775 CHOYP_THIKA.1.1 m.13333 sp THIKA_RAT 63.615 426 150 4 1 424 1 423 0 526 THIKA_RAT reviewed "3-ketoacyl-CoA thiolase A, peroxisomal (EC 2.3.1.16) (Acetyl-CoA acyltransferase A) (Beta-ketothiolase A) (Peroxisomal 3-oxoacyl-CoA thiolase A)" Acaa1a Rattus norvegicus (Rat) 424 fatty acid beta-oxidation [GO:0006635]; response to drug [GO:0042493]; response to nutrient [GO:0007584]; response to steroid hormone [GO:0048545] GO:0003988; GO:0005777; GO:0006635; GO:0007584; GO:0016401; GO:0042493; GO:0048545 PATHWAY: Lipid metabolism; fatty acid metabolism. 0 0 PF02803;PF00108; P21839 CHOYP_LOC100367645.1.1 m.29695 sp ODBB_BOVIN 70.026 387 110 2 1 382 7 392 0 568 ODBB_BOVIN reviewed "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)" BCKDHB Bos taurus (Bovine) 392 0 GO:0003863; GO:0005759 0 0 0 PF02779;PF02780; P21868 CHOYP_CSK21.1.2 m.19313 sp CSK21_CHICK 78.608 388 77 3 2 384 4 390 0 600 CSK21_CHICK reviewed Casein kinase II subunit alpha (CK II) (EC 2.7.11.1) CSNK2A1 Gallus gallus (Chicken) 391 rhythmic process [GO:0048511]; Wnt signaling pathway [GO:0016055] GO:0004674; GO:0005524; GO:0005634; GO:0016055; GO:0048511 0 0 0 PF00069; P21868 CHOYP_CSK21.2.2 m.28275 sp CSK21_CHICK 78.663 389 77 3 2 385 4 391 0 604 CSK21_CHICK reviewed Casein kinase II subunit alpha (CK II) (EC 2.7.11.1) CSNK2A1 Gallus gallus (Chicken) 391 rhythmic process [GO:0048511]; Wnt signaling pathway [GO:0016055] GO:0004674; GO:0005524; GO:0005634; GO:0016055; GO:0048511 0 0 0 PF00069; P22033 CHOYP_MUTA.1.1 m.31799 sp MUTA_HUMAN 74.406 715 182 1 131 845 28 741 0 1145 MUTA_HUMAN reviewed "Methylmalonyl-CoA mutase, mitochondrial (MCM) (EC 5.4.99.2) (Methylmalonyl-CoA isomerase)" MUT Homo sapiens (Human) 750 cobalamin metabolic process [GO:0009235]; homocysteine metabolic process [GO:0050667]; post-embryonic development [GO:0009791]; short-chain fatty acid catabolic process [GO:0019626] GO:0004494; GO:0005739; GO:0005759; GO:0009235; GO:0009791; GO:0019626; GO:0031419; GO:0046872; GO:0050667; GO:0072341 0 0 0 PF02310;PF01642; P22059 CHOYP_OSBP1.1.1 m.12788 sp OSBP1_HUMAN 53.402 779 274 11 14 767 93 807 0 795 OSBP1_HUMAN reviewed Oxysterol-binding protein 1 OSBP OSBP1 Homo sapiens (Human) 807 positive regulation of growth of symbiont in host [GO:0044128]; sterol transport [GO:0015918] GO:0000139; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0008142; GO:0015248; GO:0015918; GO:0016020; GO:0019904; GO:0030054; GO:0044128; GO:0048471; GO:0070273 0 0 0 PF01237;PF00169; P22892 CHOYP_AP1G1.1.1 m.13111 sp AP1G1_MOUSE 62.069 841 283 8 7 830 1 822 0 1056 AP1G1_MOUSE reviewed AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma-adaptin) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1) Ap1g1 Adtg Clapg1 Mus musculus (Mouse) 822 endosome to melanosome transport [GO:0035646]; Golgi to lysosome transport [GO:0090160]; intracellular protein transport [GO:0006886]; positive regulation of natural killer cell degranulation [GO:0043323]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; vesicle-mediated transport [GO:0016192] GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0006886; GO:0008565; GO:0016020; GO:0016192; GO:0017137; GO:0019894; GO:0030131; GO:0030136; GO:0030665; GO:0030742; GO:0035646; GO:0043231; GO:0043323; GO:0045954; GO:0048471; GO:0055037; GO:0090160 0 0 0 PF01602;PF02883; P23098 CHOYP_DYHC.1.3 m.10664 sp DYHC_TRIGR 73.97 4464 1149 6 9 4463 6 4465 0 7031 DYHC_TRIGR reviewed "Dynein beta chain, ciliary" 0 Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) 4466 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0030030; GO:0030286; GO:0031514 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; P23128 CHOYP_LOC100161360.1.1 m.65809 sp DDX6_DROME 80.988 405 77 0 21 425 28 432 0 704 DDX6_DROME reviewed Putative ATP-dependent RNA helicase me31b (EC 3.6.4.13) (Maternal expression at 31B) me31B CG4916 Drosophila melanogaster (Fruit fly) 459 cytoplasmic mRNA processing body assembly [GO:0033962]; gene silencing by miRNA [GO:0035195]; habituation [GO:0046959]; mitotic G2 DNA damage checkpoint [GO:0007095]; ovarian follicle cell development [GO:0030707]; pole cell formation [GO:0007279]; regulation of defense response to virus [GO:0050688]; regulation of glucose metabolic process [GO:0010906]; regulation of olfactory learning [GO:0090328]; RNA secondary structure unwinding [GO:0010501] GO:0000932; GO:0003723; GO:0004004; GO:0005524; GO:0005737; GO:0005875; GO:0007095; GO:0007279; GO:0010494; GO:0010501; GO:0010906; GO:0030707; GO:0033962; GO:0035195; GO:0043186; GO:0046959; GO:0050688; GO:0090328 0 0 0 PF00270;PF00271; P23258 CHOYP_TBG1.1.1 m.28190 sp TBG1_HUMAN 87.556 450 56 0 31 480 1 450 0 848 TBG1_HUMAN reviewed Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) TUBG1 TUBG Homo sapiens (Human) 451 cytoplasmic microtubule organization [GO:0031122]; G2/M transition of mitotic cell cycle [GO:0000086]; meiotic spindle organization [GO:0000212]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020] GO:0000086; GO:0000212; GO:0000226; GO:0000242; GO:0000794; GO:0000930; GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005813; GO:0005814; GO:0005827; GO:0005829; GO:0005881; GO:0007020; GO:0031122; GO:0031252; GO:0031513; GO:0036064; GO:0045177; GO:0055037 0 0 cd02188; PF00091;PF03953; P23378 CHOYP_GCSP.1.1 m.46644 sp GCSP_HUMAN 68.12 963 303 3 41 1003 53 1011 0 1375 GCSP_HUMAN reviewed "Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring))" GLDC GCSP Homo sapiens (Human) 1020 glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; glyoxylate metabolic process [GO:0046487] GO:0004375; GO:0005634; GO:0005739; GO:0005759; GO:0005886; GO:0005960; GO:0006546; GO:0009055; GO:0016594; GO:0016829; GO:0019464; GO:0046487 0 0 cd00613; PF01212;PF02347; P23381 CHOYP_SYWC.3.5 m.26200 sp SYWC_HUMAN 71.311 366 102 1 21 386 81 443 0 546 SYWC_HUMAN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS IFI53 WRS Homo sapiens (Human) 471 angiogenesis [GO:0001525]; negative regulation of cell proliferation [GO:0008285]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0001525; GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006412; GO:0006418; GO:0006436; GO:0008285; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P23514 CHOYP_COPB.1.1 m.16988 sp COPB_RAT 76.396 949 220 4 39 984 2 949 0 1518 COPB_RAT reviewed Coatomer subunit beta (Beta-coat protein) (Beta-COP) Copb1 Copb Rattus norvegicus (Rat) 953 "intracellular protein transport [GO:0006886]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005198; GO:0005783; GO:0005793; GO:0005794; GO:0005798; GO:0005886; GO:0006886; GO:0006890; GO:0006891; GO:0030126 0 0 0 PF01602;PF07718;PF14806; P23786 CHOYP_CPT2.1.1 m.16349 sp CPT2_HUMAN 52.119 637 300 3 28 661 21 655 0 710 CPT2_HUMAN reviewed "Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II)" CPT2 CPT1 Homo sapiens (Human) 658 carnitine shuttle [GO:0006853]; fatty acid beta-oxidation [GO:0006635] GO:0004095; GO:0005654; GO:0005730; GO:0005739; GO:0005743; GO:0006635; GO:0006853 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00755; P23787 CHOYP_TERA.1.1 m.29200 sp TERA_XENLA 87.345 806 92 5 1 798 1 804 0 1405 TERA_XENLA reviewed Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (p97) (Valosin-containing protein) (VCP) vcp Xenopus laevis (African clawed frog) 805 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein hexamerization [GO:0034214]; protein N-linked glycosylation via asparagine [GO:0018279]; protein ubiquitination [GO:0016567]; translesion synthesis [GO:0019985]; transport [GO:0006810] GO:0000785; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006302; GO:0006810; GO:0006914; GO:0006974; GO:0008289; GO:0016567; GO:0016887; GO:0018279; GO:0019985; GO:0030433; GO:0032403; GO:0034214; GO:0035861; GO:0036503; GO:0043161; GO:0097352 0 0 0 PF00004;PF02933;PF02359;PF09336; P24014 CHOYP_SLIT.1.2 m.12306 sp SLIT_DROME 39.117 974 425 18 1 855 579 1503 0 684 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P24014 CHOYP_SLIT.2.2 m.21401 sp SLIT_DROME 46.33 1485 697 17 29 1467 73 1503 0 1340 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P24346 CHOYP_DDX3Y.1.1 m.3679 sp DDX3_XENLA 58.767 730 203 16 1 718 1 644 0 778 DDX3_XENLA reviewed Putative ATP-dependent RNA helicase an3 (EC 3.6.4.13) an3 Xenopus laevis (African clawed frog) 697 0 GO:0003723; GO:0004386; GO:0005524 0 0 0 PF00270;PF00271; P24733 CHOYP_MYS.1.7 m.432 sp MYS_ARGIR 69.58 595 138 5 7 583 3 572 0 857 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P24733 CHOYP_MYS.2.7 m.2065 sp MYS_ARGIR 80.331 544 99 4 17 556 351 890 0 914 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P24733 CHOYP_MYS.2.7 m.2069 sp MYS_ARGIR 77.871 357 75 2 4 358 3 357 0 597 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P24733 CHOYP_MYS.4.7 m.18188 sp MYS_ARGIR 76.843 1926 438 2 7 1932 3 1920 0 2991 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P24733 CHOYP_MYS.7.7 m.44341 sp MYS_ARGIR 79.127 939 189 4 4 938 3 938 0 1541 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P24733 CHOYP_MYS.7.7 m.44342 sp MYS_ARGIR 71.05 981 284 0 1 981 940 1920 0 1310 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P25455 CHOYP_LOC100888919.1.1 m.1193 sp PIP1_DROME 49.351 1078 446 16 31 1059 5 1031 0 978 PIP1_DROME reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II (EC 3.1.4.11) (Phosphoinositide phospholipase C)" Plc21C plc-21 CG4574 Drosophila melanogaster (Fruit fly) 1318 flight behavior [GO:0007629]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; neuron cellular homeostasis [GO:0070050]; regulation of neuromuscular synaptic transmission [GO:1900073] GO:0004435; GO:0004871; GO:0005509; GO:0005622; GO:0007629; GO:0016042; GO:0035556; GO:0070050; GO:1900073 0 0 0 PF09279;PF00388;PF00387; P25455 CHOYP_LOC100901017.1.2 m.14035 sp PIP1_DROME 44.323 1277 612 19 30 1239 5 1249 0 1014 PIP1_DROME reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II (EC 3.1.4.11) (Phosphoinositide phospholipase C)" Plc21C plc-21 CG4574 Drosophila melanogaster (Fruit fly) 1318 flight behavior [GO:0007629]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; neuron cellular homeostasis [GO:0070050]; regulation of neuromuscular synaptic transmission [GO:1900073] GO:0004435; GO:0004871; GO:0005509; GO:0005622; GO:0007629; GO:0016042; GO:0035556; GO:0070050; GO:1900073 0 0 0 PF09279;PF00388;PF00387; P25455 CHOYP_LOC100901017.2.2 m.20038 sp PIP1_DROME 50.237 1053 451 15 7 1012 5 1031 0 986 PIP1_DROME reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II (EC 3.1.4.11) (Phosphoinositide phospholipase C)" Plc21C plc-21 CG4574 Drosophila melanogaster (Fruit fly) 1318 flight behavior [GO:0007629]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; neuron cellular homeostasis [GO:0070050]; regulation of neuromuscular synaptic transmission [GO:1900073] GO:0004435; GO:0004871; GO:0005509; GO:0005622; GO:0007629; GO:0016042; GO:0035556; GO:0070050; GO:1900073 0 0 0 PF09279;PF00388;PF00387; P26043 CHOYP_RADI.1.2 m.2373 sp RADI_MOUSE 65.641 585 181 4 2 570 3 583 0 738 RADI_MOUSE reviewed Radixin (ESP10) Rdx Mus musculus (Mouse) 583 actin filament capping [GO:0051693]; apical protein localization [GO:0045176]; cellular response to thyroid hormone stimulus [GO:0097067]; establishment of endothelial barrier [GO:0061028]; establishment of protein localization [GO:0045184]; establishment of protein localization to plasma membrane [GO:0090002]; microvillus assembly [GO:0030033]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of organelle assembly [GO:1902115]; regulation of ruffle assembly [GO:1900027] GO:0001726; GO:0003779; GO:0005615; GO:0005886; GO:0005902; GO:0005925; GO:0008360; GO:0008361; GO:0010628; GO:0016324; GO:0019898; GO:0019904; GO:0030027; GO:0030033; GO:0030175; GO:0030335; GO:0030864; GO:0032154; GO:0032231; GO:0032420; GO:0034111; GO:0034260; GO:0042803; GO:0043087; GO:0043209; GO:0044822; GO:0045176; GO:0045177; GO:0045184; GO:0045792; GO:0051117; GO:0051693; GO:0061028; GO:0070062; GO:0071944; GO:0090002; GO:0097067; GO:1900027; GO:1900087; GO:1902115; GO:1902966; GO:1903364; GO:1903392; GO:2000643 0 0 0 PF00769;PF09380;PF00373;PF09379; P26640 CHOYP_SYVC.1.1 m.14588 sp SYVC_HUMAN 60.456 526 196 4 65 579 279 803 0 676 SYVC_HUMAN reviewed Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) VARS G7A VARS2 Homo sapiens (Human) 1264 tRNA aminoacylation for protein translation [GO:0006418]; valyl-tRNA aminoacylation [GO:0006438] GO:0002161; GO:0004832; GO:0005524; GO:0005739; GO:0005829; GO:0006418; GO:0006438 0 0 cd07962; PF08264;PF00043;PF00133; P26696 CHOYP_MK01.1.1 m.48878 sp MK01_XENLA 82.865 356 61 0 23 378 3 358 0 619 MK01_XENLA reviewed Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (M phase MAP kinase) (Myelin basic protein kinase) (MBP kinase) (Myelin xP42 protein kinase) mapk1 mpk1 Xenopus laevis (African clawed frog) 361 apoptotic process [GO:0006915]; mitotic spindle assembly checkpoint [GO:0007094]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; regulation of protein stability [GO:0031647]; response to epidermal growth factor [GO:0070849] GO:0004674; GO:0004707; GO:0005524; GO:0005634; GO:0005737; GO:0005815; GO:0006915; GO:0007094; GO:0018105; GO:0018107; GO:0031647; GO:0070849; GO:0072686 0 0 0 PF00069; P26818 CHOYP_SMP_159010.1.1.1 m.56000 sp ARBK2_BOVIN 66.433 712 210 7 1 708 1 687 0 960 ARBK2_BOVIN reviewed Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3) ADRBK2 GRK3 Bos taurus (Bovine) 688 signal transduction [GO:0007165] GO:0004703; GO:0005524; GO:0007165; GO:0047696 0 0 0 PF00169;PF00069;PF00615; P27447 CHOYP_LOC100367326.1.1 m.56733 sp YES_XIPHE 57.253 517 206 6 1 516 40 542 0 593 YES_XIPHE reviewed Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) yes Xiphophorus helleri (Green swordtail) 544 innate immune response [GO:0045087] GO:0004715; GO:0005524; GO:0045087 0 0 0 PF07714;PF00017;PF00018; P27447 CHOYP_SRC.1.2 m.2504 sp YES_XIPHE 57.253 517 206 6 1 516 40 542 0 593 YES_XIPHE reviewed Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) yes Xiphophorus helleri (Green swordtail) 544 innate immune response [GO:0045087] GO:0004715; GO:0005524; GO:0045087 0 0 0 PF07714;PF00017;PF00018; P27447 CHOYP_SRC.2.2 m.40484 sp YES_XIPHE 57.055 489 195 6 1 488 40 514 0 559 YES_XIPHE reviewed Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) yes Xiphophorus helleri (Green swordtail) 544 innate immune response [GO:0045087] GO:0004715; GO:0005524; GO:0045087 0 0 0 PF07714;PF00017;PF00018; P27653 CHOYP_C1TC.1.1 m.28294 sp C1TC_RAT 70.279 932 276 1 2 933 4 934 0 1347 C1TC_RAT reviewed "C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]" Mthfd1 Mthfd Rattus norvegicus (Rat) 935 folic acid-containing compound biosynthetic process [GO:0009396]; histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; nucleotide metabolic process [GO:0009117]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] GO:0000105; GO:0004329; GO:0004477; GO:0004486; GO:0004488; GO:0005524; GO:0005737; GO:0005829; GO:0006164; GO:0006730; GO:0009086; GO:0009117; GO:0009396; GO:0035999; GO:0046653 PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. 0 cd00477; PF01268;PF00763;PF02882; P27659 CHOYP_LOC100199663.1.1 m.22109 sp RL3_MOUSE 72.98 396 107 0 10 405 1 396 0 627 RL3_MOUSE reviewed 60S ribosomal protein L3 (J1 protein) Rpl3 Mus musculus (Mouse) 403 cellular response to interleukin-4 [GO:0071353]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005925; GO:0006412; GO:0022625; GO:0044822; GO:0070062; GO:0071353 0 0 0 PF00297; P27694 CHOYP_RFA1.1.1 m.16020 sp RFA1_HUMAN 50.698 645 269 9 6 638 5 612 0 643 RFA1_HUMAN reviewed "Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]" RPA1 REPA1 RPA70 Homo sapiens (Human) 616 "base-excision repair [GO:0006284]; DNA damage response, detection of DNA damage [GO:0042769]; DNA-dependent DNA replication [GO:0006261]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; interstrand cross-link repair [GO:0036297]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; regulation of signal transduction by p53 class mediator [GO:1901796]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]" GO:0000082; GO:0000722; GO:0000723; GO:0000724; GO:0000784; GO:0003684; GO:0003697; GO:0005634; GO:0005654; GO:0005662; GO:0006260; GO:0006261; GO:0006281; GO:0006283; GO:0006284; GO:0006289; GO:0006293; GO:0006294; GO:0006295; GO:0006296; GO:0006297; GO:0006298; GO:0006310; GO:0016605; GO:0016925; GO:0019985; GO:0033683; GO:0036297; GO:0042276; GO:0042769; GO:0046872; GO:0070987; GO:1900034; GO:1901796 0 0 0 PF04057;PF08646;PF16900;PF01336; P28340 CHOYP_POLD1.1.1 m.61169 sp DPOD1_HUMAN 65.314 1084 358 7 217 1289 26 1102 0 1489 DPOD1_HUMAN reviewed DNA polymerase delta catalytic subunit (EC 2.7.7.7) (DNA polymerase subunit delta p125) POLD1 POLD Homo sapiens (Human) 1107 "base-excision repair, gap-filling [GO:0006287]; cellular response to UV [GO:0034644]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication proofreading [GO:0045004]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; fatty acid homeostasis [GO:0055089]; mismatch repair [GO:0006298]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]" GO:0000109; GO:0000166; GO:0000722; GO:0000723; GO:0000731; GO:0003677; GO:0003682; GO:0003684; GO:0003887; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006271; GO:0006281; GO:0006283; GO:0006287; GO:0006296; GO:0006297; GO:0006298; GO:0008296; GO:0009411; GO:0016020; GO:0016235; GO:0019985; GO:0033683; GO:0034644; GO:0042769; GO:0043625; GO:0045004; GO:0046872; GO:0051539; GO:0055089 0 0 0 PF00136;PF03104;PF14260; P28494 CHOYP_MA2A1.1.1 m.19620 sp MA2A1_RAT 34.657 1007 596 24 105 1072 163 1146 0 578 MA2A1_RAT reviewed "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" Man2a1 Mana2 Rattus norvegicus (Rat) 1148 in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mannose metabolic process [GO:0006013]; mitochondrion organization [GO:0007005]; N-glycan processing [GO:0006491]; positive regulation of neurogenesis [GO:0050769]; respiratory gaseous exchange [GO:0007585]; retina morphogenesis in camera-type eye [GO:0060042]; vacuole organization [GO:0007033] GO:0000139; GO:0001701; GO:0001889; GO:0004572; GO:0005801; GO:0006013; GO:0006491; GO:0007005; GO:0007033; GO:0007585; GO:0008270; GO:0016021; GO:0016799; GO:0030246; GO:0048286; GO:0050769; GO:0060042; GO:0070062 PATHWAY: Protein modification; protein glycosylation. {ECO:0000303|PubMed:1885615}. 0 0 PF09261;PF01074;PF07748; P28660 CHOYP_NCKP1.1.4 m.24694 sp NCKP1_MOUSE 57.131 1178 447 15 1 1171 1 1127 0 1347 NCKP1_MOUSE reviewed Nck-associated protein 1 (NAP 1) (Brain protein H19) (MH19) (Membrane-associated protein HEM-2) (p125Nap1) Nckap1 Hem2 Kiaa0587 Nap1 Mus musculus (Mouse) 1128 "apical protein localization [GO:0045176]; basal protein localization [GO:0045175]; cell migration involved in gastrulation [GO:0042074]; embryonic body morphogenesis [GO:0010172]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube development [GO:0035050]; endoderm development [GO:0007492]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; in utero embryonic development [GO:0001701]; lamellipodium assembly [GO:0030032]; mesodermal cell migration [GO:0008078]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; notochord morphogenesis [GO:0048570]; paraxial mesoderm development [GO:0048339]; paraxial mesoderm morphogenesis [GO:0048340]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; protein stabilization [GO:0050821]; Rac protein signal transduction [GO:0016601]; regulation of protein localization [GO:0032880]; somitogenesis [GO:0001756]; zygotic determination of anterior/posterior axis, embryo [GO:0007354]" GO:0001701; GO:0001756; GO:0001843; GO:0005925; GO:0007354; GO:0007492; GO:0008078; GO:0010172; GO:0010592; GO:0016021; GO:0016601; GO:0030027; GO:0030032; GO:0030903; GO:0030950; GO:0031209; GO:0031258; GO:0032403; GO:0032880; GO:0035050; GO:0042074; GO:0045175; GO:0045176; GO:0048339; GO:0048340; GO:0048570; GO:0048617; GO:0050821; GO:0070062; GO:2000601 0 0 0 PF09735; P28660 CHOYP_NCKP1.2.4 m.39492 sp NCKP1_MOUSE 58.017 1160 445 14 1 1151 1 1127 0 1356 NCKP1_MOUSE reviewed Nck-associated protein 1 (NAP 1) (Brain protein H19) (MH19) (Membrane-associated protein HEM-2) (p125Nap1) Nckap1 Hem2 Kiaa0587 Nap1 Mus musculus (Mouse) 1128 "apical protein localization [GO:0045176]; basal protein localization [GO:0045175]; cell migration involved in gastrulation [GO:0042074]; embryonic body morphogenesis [GO:0010172]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube development [GO:0035050]; endoderm development [GO:0007492]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; in utero embryonic development [GO:0001701]; lamellipodium assembly [GO:0030032]; mesodermal cell migration [GO:0008078]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; notochord morphogenesis [GO:0048570]; paraxial mesoderm development [GO:0048339]; paraxial mesoderm morphogenesis [GO:0048340]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of lamellipodium assembly [GO:0010592]; protein stabilization [GO:0050821]; Rac protein signal transduction [GO:0016601]; regulation of protein localization [GO:0032880]; somitogenesis [GO:0001756]; zygotic determination of anterior/posterior axis, embryo [GO:0007354]" GO:0001701; GO:0001756; GO:0001843; GO:0005925; GO:0007354; GO:0007492; GO:0008078; GO:0010172; GO:0010592; GO:0016021; GO:0016601; GO:0030027; GO:0030032; GO:0030903; GO:0030950; GO:0031209; GO:0031258; GO:0032403; GO:0032880; GO:0035050; GO:0042074; GO:0045175; GO:0045176; GO:0048339; GO:0048340; GO:0048570; GO:0048617; GO:0050821; GO:0070062; GO:2000601 0 0 0 PF09735; P28668 CHOYP_LOC100376708.2.2 m.19660 sp SYEP_DROME 58.511 1504 577 14 1 1470 224 1714 0 1710 SYEP_DROME reviewed Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)] Aats-glupro CG5394 Drosophila melanogaster (Fruit fly) 1714 glutamyl-tRNA aminoacylation [GO:0006424]; prolyl-tRNA aminoacylation [GO:0006433] GO:0003723; GO:0004818; GO:0004827; GO:0005524; GO:0005737; GO:0006424; GO:0006433; GO:0017101 0 0 cd00778; PF14497;PF03129;PF09180;PF00749;PF03950;PF00587;PF00458; P28749 CHOYP_BRAFLDRAFT_218889.2.2 m.58058 sp RBL1_HUMAN 47.359 1098 449 25 94 1118 24 1065 0 969 RBL1_HUMAN reviewed Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) RBL1 Homo sapiens (Human) 1068 "cell cycle [GO:0007049]; covalent chromatin modification [GO:0016569]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of lipid kinase activity [GO:0043550]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0000122; GO:0005654; GO:0005667; GO:0006351; GO:0007049; GO:0008134; GO:0010629; GO:0016032; GO:0016569; GO:0043550; GO:0045944; GO:0051726; GO:1990841 0 0 0 PF11934;PF01858;PF01857;PF08934; P28840 CHOYP_NEC1.1.1 m.63094 sp NEC1_RAT 59.49 627 231 10 4 622 6 617 0 766 NEC1_RAT reviewed Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) Pcsk1 Bdp Nec-1 Nec1 Rattus norvegicus (Rat) 752 neurogenesis [GO:0022008]; pancreas development [GO:0031016]; peptide hormone processing [GO:0016486]; pituitary gland development [GO:0021983]; positive regulation of protein secretion [GO:0050714]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; response to axon injury [GO:0048678]; response to calcium ion [GO:0051592]; response to chlorate [GO:0010157]; response to drug [GO:0042493]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to inorganic substance [GO:0010035]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to morphine [GO:0043278]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434] GO:0004175; GO:0004252; GO:0005615; GO:0005791; GO:0005802; GO:0006508; GO:0009749; GO:0010035; GO:0010157; GO:0014070; GO:0016486; GO:0016540; GO:0021983; GO:0022008; GO:0030133; GO:0030141; GO:0030425; GO:0031016; GO:0031667; GO:0032403; GO:0032496; GO:0042493; GO:0043005; GO:0043025; GO:0043204; GO:0043278; GO:0043434; GO:0043559; GO:0043679; GO:0048471; GO:0048678; GO:0050714; GO:0051087; GO:0051384; GO:0051592; GO:0070542; GO:0070555 0 0 0 PF01483;PF00082;PF12177;PF16470; P29119 CHOYP_FURI1.2.2 m.56536 sp FURI1_XENLA 51.715 758 322 11 36 772 17 751 0 751 FURI1_XENLA reviewed Furin-1 (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) furin Xenopus laevis (African clawed frog) 783 0 GO:0004252; GO:0016021 0 0 0 PF01483;PF00082;PF16470; P29144 CHOYP_TPP2.1.1 m.24017 sp TPP2_HUMAN 52.74 1259 562 13 1 1242 1 1243 0 1309 TPP2_HUMAN reviewed Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) TPP2 Homo sapiens (Human) 1249 protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508] GO:0000209; GO:0004175; GO:0004177; GO:0004252; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0008240; GO:0042277 0 0 0 PF00082;PF12580; P29190 CHOYP_PCKG.1.2 m.43785 sp PCKG_HAECO 66.397 619 206 2 16 633 1 618 0 889 PCKG_HAECO reviewed Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) PEPCK Haemonchus contortus (Barber pole worm) 619 gluconeogenesis [GO:0006094] GO:0004613; GO:0005525; GO:0006094; GO:0046872 0 0 0 PF00821; P29190 CHOYP_PCKG.2.2 m.50139 sp PCKG_HAECO 66.45 614 204 2 16 628 1 613 0 883 PCKG_HAECO reviewed Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) PEPCK Haemonchus contortus (Barber pole worm) 619 gluconeogenesis [GO:0006094] GO:0004613; GO:0005525; GO:0006094; GO:0046872 0 0 0 PF00821; P29341 CHOYP_LOC100205111.1.1 m.22014 sp PABP1_MOUSE 60.283 637 213 13 8 620 7 627 0 717 PABP1_MOUSE reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Mus musculus (Mouse) 636 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0003729; GO:0005634; GO:0005737; GO:0005925; GO:0006397; GO:0008022; GO:0008143; GO:0008266; GO:0008380; GO:0010494; GO:0016020; GO:0030425; GO:0030529; GO:0031047; GO:0036464; GO:0044822; GO:0045070; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:1990124; GO:2000623 0 0 0 PF00658;PF00076; P29375 CHOYP_KDM5A.1.1 m.51935 sp KDM5A_HUMAN 59.44 1499 535 17 8 1461 13 1483 0 1758 KDM5A_HUMAN reviewed Lysine-specific demethylase 5A (EC 1.14.11.-) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) KDM5A JARID1A RBBP2 RBP2 Homo sapiens (Human) 1690 "circadian regulation of gene expression [GO:0032922]; histone H3-K4 demethylation [GO:0034720]; male gonad development [GO:0008584]; negative regulation of histone deacetylase activity [GO:1901726]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; spermatogenesis [GO:0007283]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006366; GO:0007283; GO:0008270; GO:0008584; GO:0016706; GO:0031490; GO:0032452; GO:0032922; GO:0032993; GO:0034720; GO:0045893; GO:1901726 0 0 0 PF01388;PF02373;PF02375;PF00628;PF08429;PF02928; P29691 CHOYP_EF2.2.5 m.15469 sp EF2_CAEEL 76.76 753 174 1 124 875 100 852 0 1222 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P29691 CHOYP_EF2.3.5 m.28897 sp EF2_CAEEL 59.742 852 333 2 1 842 1 852 0 1101 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P29691 CHOYP_EF2.4.5 m.30186 sp EF2_CAEEL 76.995 852 186 2 1 842 1 852 0 1375 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P29691 CHOYP_EF2.5.5 m.39855 sp EF2_CAEEL 76.643 852 189 2 1 842 1 852 0 1367 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P30051 CHOYP_TEAD1.1.1 m.58471 sp TEAD1_MOUSE 71.429 441 92 9 3 427 4 426 0 625 TEAD1_MOUSE reviewed Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) Tead1 Tcf13 Tef-1 Tef1 Mus musculus (Mouse) 426 "cellular response to retinoic acid [GO:0071300]; embryonic heart tube morphogenesis [GO:0003143]; heart development [GO:0007507]; hippo signaling [GO:0035329]; lateral mesoderm development [GO:0048368]; notochord development [GO:0030903]; paraxial mesoderm development [GO:0048339]; positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of stem cell population maintenance [GO:1902459]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell proliferation [GO:0042127]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; transition between fast and slow fiber [GO:0014883]" GO:0000982; GO:0001159; GO:0003143; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0006351; GO:0006355; GO:0007507; GO:0014883; GO:0030903; GO:0035329; GO:0042127; GO:0045944; GO:0048339; GO:0048368; GO:0071300; GO:0071902; GO:1902459; GO:1902895 0 0 0 PF01285; P30260 CHOYP_CDC27.1.1 m.10784 sp CDC27_HUMAN 50.999 851 353 19 26 842 3 823 0 786 CDC27_HUMAN reviewed Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC) CDC27 ANAPC3 D0S1430E D17S978E Homo sapiens (Human) 824 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell proliferation [GO:0008283]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005634; GO:0005654; GO:0005680; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0007091; GO:0008283; GO:0019903; GO:0031145; GO:0042787; GO:0043161; GO:0051436; GO:0051437; GO:0051439; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00515;PF13181; P30682 CHOYP_GNAI.1.1 m.26096 sp GNAI_LYMST 84.594 357 52 1 1 357 1 354 0 644 GNAI_LYMST reviewed Guanine nucleotide-binding protein G(i) subunit alpha (Adenylate cyclase-inhibiting G alpha protein) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 354 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] GO:0003924; GO:0004871; GO:0005525; GO:0007188; GO:0046872 0 0 0 PF00503; P30683 CHOYP_GNAO.1.1 m.37355 sp GNAO_LYMST 92.938 354 25 0 1 354 1 354 0 692 GNAO_LYMST reviewed Guanine nucleotide-binding protein G(o) subunit alpha 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 354 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188] GO:0003924; GO:0004871; GO:0005525; GO:0007188; GO:0046872 0 0 0 PF00503; P30684 CHOYP_GNAS.3.3 m.55756 sp GNAS_LYMST 82.54 378 64 1 1 378 1 376 0 659 GNAS_LYMST reviewed Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 376 G-protein coupled receptor signaling pathway [GO:0007186] GO:0003924; GO:0004871; GO:0005525; GO:0007186; GO:0046872 0 0 0 PF00503; P30825 CHOYP_CTR2.1.1 m.18573 sp CTR1_HUMAN 52.913 618 260 5 6 593 11 627 0 636 CTR1_HUMAN reviewed High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homolog) (Ecotropic retrovirus receptor homolog) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) SLC7A1 ATRC1 ERR REC1L Homo sapiens (Human) 629 amino acid transport [GO:0006865]; arginine transport [GO:0015809]; L-ornithine transmembrane transport [GO:1903352]; transport [GO:0006810] GO:0000064; GO:0005886; GO:0005887; GO:0006810; GO:0006865; GO:0015171; GO:0015181; GO:0015189; GO:0015297; GO:0015809; GO:0016020; GO:1903352 0 0 0 PF13520;PF13906; P30837 CHOYP_NEMVEDRAFT_V1G181421.1.1 m.3106 sp AL1B1_HUMAN 60.606 495 194 1 2 495 23 517 0 646 AL1B1_HUMAN reviewed "Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1)" ALDH1B1 ALDH5 ALDHX Homo sapiens (Human) 517 carbohydrate metabolic process [GO:0005975]; ethanol catabolic process [GO:0006068]; ethanol oxidation [GO:0006069] GO:0004029; GO:0005654; GO:0005739; GO:0005759; GO:0005975; GO:0006068; GO:0006069; GO:0043231 PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. 0 0 PF00171; P30876 CHOYP_RPB2.1.1 m.38872 sp RPB2_HUMAN 88.416 1174 134 1 1 1174 1 1172 0 2224 RPB2_HUMAN reviewed DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2) POLR2B Homo sapiens (Human) 1174 "7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; gene silencing by RNA [GO:0031047]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral transcription [GO:0050434]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; somatic stem cell population maintenance [GO:0035019]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000398; GO:0003677; GO:0003682; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0006283; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0008543; GO:0010467; GO:0016020; GO:0031047; GO:0032549; GO:0035019; GO:0042795; GO:0044822; GO:0046872; GO:0050434 0 0 cd00653; PF04563;PF04561;PF04565;PF04566;PF04567;PF00562;PF04560; P30946 CHOYP_LOC100696358.1.1 m.27371 sp HS90A_RABIT 80.336 417 62 3 7 423 12 408 0 668 HS90A_RABIT reviewed Heat shock protein HSP 90-alpha HSP90AA1 HSPCA Oryctolagus cuniculus (Rabbit) 694 protein folding [GO:0006457]; response to antibiotic [GO:0046677]; response to cold [GO:0009409]; response to heat [GO:0009408] GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0006457; GO:0009408; GO:0009409; GO:0042470; GO:0046677 0 0 0 PF02518;PF00183; P31319 CHOYP_KAPR.1.3 m.8246 sp KAPR_APLCA 84.911 338 47 2 73 407 42 378 0 582 KAPR_APLCA reviewed cAMP-dependent protein kinase regulatory subunit (N4 subunit of protein kinase A) 0 Aplysia californica (California sea hare) 378 0 GO:0005952; GO:0008603; GO:0030552 0 0 0 PF00027;PF02197; P31319 CHOYP_KAPR.2.3 m.56519 sp KAPR_APLCA 82.653 392 51 3 1 389 1 378 0 657 KAPR_APLCA reviewed cAMP-dependent protein kinase regulatory subunit (N4 subunit of protein kinase A) 0 Aplysia californica (California sea hare) 378 0 GO:0005952; GO:0008603; GO:0030552 0 0 0 PF00027;PF02197; P31335 CHOYP_ATIC.1.1 m.17816 sp PUR9_CHICK 67.857 588 187 2 8 594 7 593 0 840 PUR9_CHICK reviewed Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] ATIC PURH Gallus gallus (Chicken) 593 'de novo' IMP biosynthetic process [GO:0006189] GO:0003937; GO:0004643; GO:0005829; GO:0006189; GO:0042803 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. 0 0 PF01808;PF02142; P31401 CHOYP_VATB.1.2 m.33785 sp VATB_MANSE 91.002 489 44 0 29 517 5 493 0 942 VATB_MANSE reviewed V-type proton ATPase subunit B (V-ATPase subunit B) (Vacuolar proton pump subunit B) VHA55 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 494 ATP hydrolysis coupled proton transport [GO:0015991]; ATP metabolic process [GO:0046034] GO:0005524; GO:0015991; GO:0016820; GO:0033180; GO:0046034 0 0 0 PF00006;PF02874; P31401 CHOYP_VATB.2.2 m.62085 sp VATB_MANSE 91.002 489 44 0 10 498 5 493 0 941 VATB_MANSE reviewed V-type proton ATPase subunit B (V-ATPase subunit B) (Vacuolar proton pump subunit B) VHA55 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 494 ATP hydrolysis coupled proton transport [GO:0015991]; ATP metabolic process [GO:0046034] GO:0005524; GO:0015991; GO:0016820; GO:0033180; GO:0046034 0 0 0 PF00006;PF02874; P31424 CHOYP_GRM5.1.1 m.14355 sp GRM5_RAT 51.16 776 366 8 1 771 80 847 0 819 GRM5_RAT reviewed Metabotropic glutamate receptor 5 (mGluR5) Grm5 Gprc1e Mglur5 Rattus norvegicus (Rat) 1203 "activation of MAPKKK activity [GO:0000185]; chemical synaptic transmission [GO:0007268]; desensitization of G-protein coupled receptor protein signaling pathway [GO:0002029]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of locomotion [GO:0040013]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein phosphorylation [GO:0006468]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000185; GO:0001639; GO:0002029; GO:0004930; GO:0005516; GO:0005887; GO:0006355; GO:0006468; GO:0007205; GO:0007206; GO:0007216; GO:0007268; GO:0008066; GO:0014069; GO:0016020; GO:0030165; GO:0031687; GO:0040013; GO:0043197; GO:0043198; GO:0045211; GO:0048015; GO:0048170; GO:0051482; GO:0051966; GO:0097449 0 0 0 PF00003;PF01094;PF10606;PF07562; P31637 CHOYP_LOC100376458.1.1 m.33708 sp SC5A3_CANLF 48.611 720 319 11 23 697 5 718 0 686 SC5A3_CANLF reviewed Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3) SLC5A3 SMIT Canis lupus familiaris (Dog) (Canis familiaris) 718 inositol metabolic process [GO:0006020]; myo-inositol transport [GO:0015798]; peripheral nervous system development [GO:0007422]; regulation of respiratory gaseous exchange [GO:0043576] GO:0005367; GO:0005887; GO:0006020; GO:0007422; GO:0015798; GO:0043576 0 0 0 PF00474; P31646 CHOYP_SC6A6.2.2 m.37040 sp S6A13_RAT 45.867 617 281 8 12 625 21 587 0 565 S6A13_RAT reviewed Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gat-2 Rattus norvegicus (Rat) 602 chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836] GO:0005328; GO:0005332; GO:0005887; GO:0006836; GO:0007268; GO:0042165; GO:0043005 0 0 0 PF00209; P31649 CHOYP_LOC100533491.1.1 m.50751 sp S6A13_MOUSE 51.232 609 258 7 42 640 2 581 0 620 S6A13_MOUSE reviewed Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gabt3 Gat-3 Gat2 Gat3 Mus musculus (Mouse) 602 chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid transport [GO:0015812]; neurotransmitter transport [GO:0006836] GO:0005328; GO:0005332; GO:0005887; GO:0006836; GO:0007268; GO:0015812; GO:0042165; GO:0043005; GO:0070062 0 0 0 PF00209; P31948 CHOYP_STIP1.1.2 m.12856 sp STIP1_HUMAN 52.065 557 243 5 12 564 7 543 0 550 STIP1_HUMAN reviewed Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) STIP1 Homo sapiens (Human) 543 response to stress [GO:0006950] GO:0005634; GO:0005794; GO:0006950; GO:0043209; GO:0043234; GO:0044822 0 0 0 PF13414;PF07719;PF13181; P31948 CHOYP_STIP1.2.2 m.54723 sp STIP1_HUMAN 52.065 557 243 5 24 576 7 543 0 551 STIP1_HUMAN reviewed Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521) STIP1 Homo sapiens (Human) 543 response to stress [GO:0006950] GO:0005634; GO:0005794; GO:0006950; GO:0043209; GO:0043234; GO:0044822 0 0 0 PF13414;PF07719;PF13181; P32138 CHOYP_LOC100369482.1.2 m.4562 sp SQASE_ECOLI 43.358 685 368 4 26 709 10 675 0 603 SQASE_ECOLI reviewed Sulfoquinovosidase (SQase) (EC 3.2.1.-) yihQ squQ b3878 JW3849 Escherichia coli (strain K12) 678 carbohydrate metabolic process [GO:0005975] GO:0004553; GO:0005975; GO:0030246 PATHWAY: Glycolipid metabolism. {ECO:0000305|PubMed:24463506}. 0 0 PF01055; P32234 CHOYP_DRG1.1.1 m.28901 sp 128UP_DROME 83.014 365 61 1 3 366 4 368 0 617 128UP_DROME reviewed GTP-binding protein 128up 128up GTP-bp CG8340 Drosophila melanogaster (Fruit fly) 368 0 GO:0005525 0 0 0 PF01926;PF16897;PF02824; P32577 CHOYP_CSK.1.1 m.55145 sp CSK_RAT 58.744 446 172 6 13 451 5 445 0 544 CSK_RAT reviewed Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) Csk Rattus norvegicus (Rat) 450 adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; brain development [GO:0007420]; cell migration [GO:0016477]; cellular response to peptide hormone stimulus [GO:0071375]; innate immune response [GO:0045087]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of kinase activity [GO:0033673]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of MAP kinase activity [GO:0043406]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0002250; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005737; GO:0005911; GO:0006468; GO:0007169; GO:0007420; GO:0008285; GO:0010989; GO:0016477; GO:0019903; GO:0031234; GO:0032715; GO:0033673; GO:0034332; GO:0038083; GO:0042997; GO:0043406; GO:0045087; GO:0045121; GO:0045779; GO:0046777; GO:0046872; GO:0048709; GO:0050765; GO:0060368; GO:0070062; GO:0070064; GO:0070373; GO:0071375 0 0 0 PF07714;PF00017;PF00018; P32755 CHOYP_LOC594130.1.1 m.48747 sp HPPD_RAT 68.063 382 121 1 33 414 1 381 0 564 HPPD_RAT reviewed 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) (F Alloantigen) (F protein) Hpd Rattus norvegicus (Rat) 393 L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] GO:0000139; GO:0003868; GO:0005783; GO:0005789; GO:0005794; GO:0006559; GO:0006572; GO:0046872 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6. 0 0 PF00903; P33121 CHOYP_ACSL5.1.1 m.22176 sp ACSL1_HUMAN 53.492 630 286 5 26 653 70 694 0 687 ACSL1_HUMAN reviewed Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) ACSL1 FACL1 FACL2 LACS LACS1 LACS2 Homo sapiens (Human) 698 adiponectin-activated signaling pathway [GO:0033211]; alpha-linolenic acid metabolic process [GO:0036109]; fatty acid transport [GO:0015908]; linoleic acid metabolic process [GO:0043651]; lipid biosynthetic process [GO:0008610]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; response to drug [GO:0042493]; response to nutrient [GO:0007584]; response to oleic acid [GO:0034201]; response to organic cyclic compound [GO:0014070]; triglyceride metabolic process [GO:0006641]; xenobiotic catabolic process [GO:0042178] GO:0001676; GO:0004467; GO:0005524; GO:0005739; GO:0005741; GO:0005778; GO:0005789; GO:0005886; GO:0006641; GO:0007584; GO:0008610; GO:0014070; GO:0015908; GO:0016020; GO:0016021; GO:0033211; GO:0034201; GO:0035338; GO:0036109; GO:0042178; GO:0042493; GO:0043651; GO:0044539; GO:0071902; GO:0102391 0 0 0 PF00501; P34147 CHOYP_LOC752289.1.1 m.53931 sp RACA_DICDI 46.885 610 279 10 1 587 1 588 0 552 RACA_DICDI reviewed Rho-related protein racA racA DDB_G0286555 Dictyostelium discoideum (Slime mold) 598 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0019901 0 0 0 PF00651;PF00071; P34611 CHOYP_LOC100902046.1.1 m.11187 sp NCL1_CAEEL 48.509 738 296 16 109 777 113 835 0 667 NCL1_CAEEL reviewed B-box type zinc finger protein ncl-1 ncl-1 ZK112.2 Caenorhabditis elegans 851 negative regulation of ribosome biogenesis [GO:0090071] GO:0005737; GO:0008270; GO:0090071 0 0 0 PF01436;PF00643; P34897 CHOYP_SHMT2.1.1 m.10572 sp GLYM_HUMAN 65.727 461 157 1 43 502 43 503 0 665 GLYM_HUMAN reviewed "Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)" SHMT2 Homo sapiens (Human) 504 folic acid metabolic process [GO:0046655]; glycine biosynthetic process from serine [GO:0019264]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; one-carbon metabolic process [GO:0006730]; positive regulation of cell proliferation [GO:0008284]; protein homotetramerization [GO:0051289]; protein K63-linked deubiquitination [GO:0070536]; protein tetramerization [GO:0051262]; response to type I interferon [GO:0034340]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] GO:0003682; GO:0004372; GO:0005634; GO:0005737; GO:0005739; GO:0005743; GO:0005758; GO:0005759; GO:0006544; GO:0006563; GO:0006564; GO:0006730; GO:0008284; GO:0008732; GO:0015630; GO:0016597; GO:0019264; GO:0030170; GO:0034340; GO:0035999; GO:0042645; GO:0046653; GO:0046655; GO:0051262; GO:0051289; GO:0070062; GO:0070536; GO:0070552 PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000305|PubMed:25619277}. 0 cd00378; PF00464; P35224 CHOYP_ATC1.1.1 m.5161 sp CTNB_URECA 80.552 761 119 13 11 763 79 818 0 1197 CTNB_URECA reviewed Catenin beta (Beta-catenin) 0 Urechis caupo (Innkeeper worm) (Spoonworm) 818 adherens junction assembly [GO:0034333]; cell adhesion [GO:0007155] GO:0004871; GO:0005737; GO:0005856; GO:0007155; GO:0034333 0 0 0 PF00514; P35224 CHOYP_LOC100533383.1.2 m.10357 sp CTNB_URECA 77.765 841 155 16 1 832 1 818 0 1265 CTNB_URECA reviewed Catenin beta (Beta-catenin) 0 Urechis caupo (Innkeeper worm) (Spoonworm) 818 adherens junction assembly [GO:0034333]; cell adhesion [GO:0007155] GO:0004871; GO:0005737; GO:0005856; GO:0007155; GO:0034333 0 0 0 PF00514; P35224 CHOYP_LOC100533383.1.2 m.10358 sp CTNB_URECA 84.127 693 98 8 1 692 1 682 0 1159 CTNB_URECA reviewed Catenin beta (Beta-catenin) 0 Urechis caupo (Innkeeper worm) (Spoonworm) 818 adherens junction assembly [GO:0034333]; cell adhesion [GO:0007155] GO:0004871; GO:0005737; GO:0005856; GO:0007155; GO:0034333 0 0 0 PF00514; P35240 CHOYP_MERL.1.1 m.1067 sp MERL_HUMAN 61.921 604 210 9 1 601 9 595 0 729 MERL_HUMAN reviewed Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) NF2 SCH Homo sapiens (Human) 595 actin cytoskeleton organization [GO:0030036]; cell-cell junction organization [GO:0045216]; ectoderm development [GO:0007398]; hippocampus development [GO:0021766]; lens fiber cell differentiation [GO:0070306]; mesoderm formation [GO:0001707]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell growth [GO:0030308]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of tyrosine phosphorylation of Stat3 protein [GO:0042518]; negative regulation of tyrosine phosphorylation of Stat5 protein [GO:0042524]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell differentiation [GO:0045597]; positive regulation of stress fiber assembly [GO:0051496]; regulation of gliogenesis [GO:0014013]; regulation of hippo signaling [GO:0035330]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein stability [GO:0031647]; regulation of stem cell proliferation [GO:0072091]; Schwann cell proliferation [GO:0014010] GO:0001707; GO:0001953; GO:0005634; GO:0005730; GO:0005737; GO:0005769; GO:0005856; GO:0005886; GO:0005912; GO:0006469; GO:0007398; GO:0008156; GO:0008285; GO:0014010; GO:0014013; GO:0016020; GO:0019898; GO:0021766; GO:0022408; GO:0030027; GO:0030036; GO:0030308; GO:0030336; GO:0030864; GO:0031527; GO:0031647; GO:0032154; GO:0032587; GO:0035330; GO:0042475; GO:0042518; GO:0042524; GO:0043005; GO:0043234; GO:0043409; GO:0044297; GO:0045121; GO:0045177; GO:0045202; GO:0045216; GO:0045597; GO:0046426; GO:0048471; GO:0051496; GO:0070306; GO:0072091; GO:1900180; GO:2000177 0 0 0 PF00769;PF09380;PF00373;PF09379; P35241 CHOYP_RADI.2.2 m.22447 sp RADI_HUMAN 90.635 299 28 0 1 299 1 299 0 588 RADI_HUMAN reviewed Radixin RDX Homo sapiens (Human) 583 actin filament capping [GO:0051693]; apical protein localization [GO:0045176]; cellular response to thyroid hormone stimulus [GO:0097067]; establishment of endothelial barrier [GO:0061028]; establishment of protein localization [GO:0045184]; establishment of protein localization to plasma membrane [GO:0090002]; microvillus assembly [GO:0030033]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; protein kinase A signaling [GO:0010737]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of organelle assembly [GO:1902115]; regulation of Rap protein signal transduction [GO:0032487]; regulation of ruffle assembly [GO:1900027] GO:0001726; GO:0003779; GO:0005615; GO:0005886; GO:0005902; GO:0005913; GO:0005925; GO:0008360; GO:0008361; GO:0010628; GO:0010737; GO:0016324; GO:0019898; GO:0030027; GO:0030033; GO:0030175; GO:0030335; GO:0030864; GO:0032154; GO:0032231; GO:0032420; GO:0032487; GO:0034111; GO:0034260; GO:0042803; GO:0043087; GO:0043209; GO:0044822; GO:0045176; GO:0045184; GO:0045792; GO:0051018; GO:0051117; GO:0051693; GO:0061028; GO:0070062; GO:0071944; GO:0090002; GO:0097067; GO:0098641; GO:1900027; GO:1900087; GO:1902115; GO:1902966; GO:1903364; GO:1903392; GO:2000643 0 0 0 PF00769;PF09380;PF00373;PF09379; P35251 CHOYP_RFC1.1.3 m.8918 sp RFC1_HUMAN 48.407 1130 450 21 101 1117 11 1120 0 940 RFC1_HUMAN reviewed Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) RFC1 RFC140 Homo sapiens (Human) 1148 "DNA damage response, detection of DNA damage [GO:0042769]; DNA-dependent DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; regulation of transcription, DNA-templated [GO:0006355]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]" GO:0000722; GO:0003677; GO:0003689; GO:0005524; GO:0005634; GO:0005654; GO:0005663; GO:0006261; GO:0006283; GO:0006296; GO:0006297; GO:0006351; GO:0006355; GO:0007004; GO:0008047; GO:0019985; GO:0033683; GO:0042276; GO:0042769; GO:0070062; GO:0070987 0 0 0 PF00004;PF00533;PF08519; P35500 CHOYP_LOC100533425.1.2 m.22029 sp SCNA_DROME 41.196 886 397 23 2 785 11 874 0 580 SCNA_DROME reviewed Sodium channel protein para (Protein paralytic) (Sodium channel 1) (DmNav1) para CG9907 Drosophila melanogaster (Fruit fly) 2131 "chemical synaptic transmission [GO:0007268]; male courtship behavior, veined wing generated song production [GO:0045433]; mechanosensory behavior [GO:0007638]; membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; response to DDT [GO:0046680]; response to drug [GO:0042493]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to pyrethroid [GO:0046684]; sodium ion transport [GO:0006814]" GO:0001518; GO:0001666; GO:0005248; GO:0005272; GO:0005509; GO:0005886; GO:0005887; GO:0006814; GO:0007268; GO:0007638; GO:0009612; GO:0019228; GO:0042493; GO:0045433; GO:0046680; GO:0046684; GO:0086010 0 0 0 PF16905;PF00520;PF06512;PF11933; P35500 CHOYP_LOC100533425.2.2 m.39221 sp SCNA_DROME 45.634 1523 639 35 1 1375 166 1647 0 1126 SCNA_DROME reviewed Sodium channel protein para (Protein paralytic) (Sodium channel 1) (DmNav1) para CG9907 Drosophila melanogaster (Fruit fly) 2131 "chemical synaptic transmission [GO:0007268]; male courtship behavior, veined wing generated song production [GO:0045433]; mechanosensory behavior [GO:0007638]; membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; response to DDT [GO:0046680]; response to drug [GO:0042493]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to pyrethroid [GO:0046684]; sodium ion transport [GO:0006814]" GO:0001518; GO:0001666; GO:0005248; GO:0005272; GO:0005509; GO:0005886; GO:0005887; GO:0006814; GO:0007268; GO:0007638; GO:0009612; GO:0019228; GO:0042493; GO:0045433; GO:0046680; GO:0046684; GO:0086010 0 0 0 PF16905;PF00520;PF06512;PF11933; P35559 CHOYP_IDE.1.3 m.8450 sp IDE_RAT 58.663 987 401 4 35 1018 36 1018 0 1215 IDE_RAT reviewed Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) Ide Rattus norvegicus (Rat) 1019 beta-amyloid metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular protein catabolic process [GO:0044257]; determination of adult lifespan [GO:0008340]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; negative regulation of proteolysis [GO:0045861]; peptide catabolic process [GO:0043171]; positive regulation of protein oligomerization [GO:0032461]; protein heterooligomerization [GO:0051291]; protein homotetramerization [GO:0051289]; protein processing [GO:0016485]; proteolysis involved in cellular protein catabolic process [GO:0051603]; ubiquitin homeostasis [GO:0010992] GO:0001540; GO:0001948; GO:0004222; GO:0005524; GO:0005615; GO:0005634; GO:0005654; GO:0005739; GO:0005782; GO:0005829; GO:0005886; GO:0008233; GO:0008270; GO:0008340; GO:0009986; GO:0010815; GO:0010992; GO:0016485; GO:0016887; GO:0017046; GO:0031597; GO:0031626; GO:0032461; GO:0042447; GO:0042803; GO:0043171; GO:0043559; GO:0044257; GO:0045861; GO:0050435; GO:0051289; GO:0051291; GO:0051603; GO:1901143 0 0 0 PF00675;PF05193;PF16187; P35559 CHOYP_IDE.2.3 m.66898 sp IDE_RAT 52.713 516 243 1 3 518 43 557 0 571 IDE_RAT reviewed Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) Ide Rattus norvegicus (Rat) 1019 beta-amyloid metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular protein catabolic process [GO:0044257]; determination of adult lifespan [GO:0008340]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; negative regulation of proteolysis [GO:0045861]; peptide catabolic process [GO:0043171]; positive regulation of protein oligomerization [GO:0032461]; protein heterooligomerization [GO:0051291]; protein homotetramerization [GO:0051289]; protein processing [GO:0016485]; proteolysis involved in cellular protein catabolic process [GO:0051603]; ubiquitin homeostasis [GO:0010992] GO:0001540; GO:0001948; GO:0004222; GO:0005524; GO:0005615; GO:0005634; GO:0005654; GO:0005739; GO:0005782; GO:0005829; GO:0005886; GO:0008233; GO:0008270; GO:0008340; GO:0009986; GO:0010815; GO:0010992; GO:0016485; GO:0016887; GO:0017046; GO:0031597; GO:0031626; GO:0032461; GO:0042447; GO:0042803; GO:0043171; GO:0043559; GO:0044257; GO:0045861; GO:0050435; GO:0051289; GO:0051291; GO:0051603; GO:1901143 0 0 0 PF00675;PF05193;PF16187; P35573 CHOYP_GDE.1.1 m.54948 sp GDE_HUMAN 50.16 1559 727 17 3 1541 4 1532 0 1560 GDE_HUMAN reviewed "Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]" AGL GDE Homo sapiens (Human) 1532 glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; response to glucocorticoid [GO:0051384]; response to nutrient [GO:0007584] GO:0004133; GO:0004134; GO:0004135; GO:0005634; GO:0005737; GO:0005829; GO:0005978; GO:0005980; GO:0007584; GO:0016234; GO:0016529; GO:0030247; GO:0043033; GO:0051384 0 0 cd11327; PF06202;PF14701;PF14702;PF14699; P35606 CHOYP_COPB2.1.1 m.11046 sp COPB2_HUMAN 72.939 946 212 5 1 942 1 906 0 1456 COPB2_HUMAN reviewed Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) COPB2 Homo sapiens (Human) 906 "ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; toxin transport [GO:1901998]" GO:0000139; GO:0005198; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0006890; GO:0006891; GO:0030126; GO:0030133; GO:1901998 0 0 0 PF04053;PF00400; P35623 CHOYP_LOC100371236.1.1 m.62865 sp GLYC_SHEEP 66.447 456 149 2 32 483 29 484 0 637 GLYC_SHEEP reviewed "Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)" SHMT1 Ovis aries (Sheep) 484 glycine metabolic process [GO:0006544]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] GO:0004372; GO:0005829; GO:0006544; GO:0006563; GO:0030170; GO:0035999; GO:0046653; GO:0051289 PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000305}. 0 cd00378; PF00464; P35832 CHOYP_LOC660278.1.2 m.9147 sp PTP99_DROME 39.512 901 473 17 394 1282 170 1010 0 625 PTP99_DROME reviewed Tyrosine-protein phosphatase 99A (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 99A) (DPTP99A) Ptp99A CG2005 Drosophila melanogaster (Fruit fly) 1301 axonal defasciculation [GO:0007414]; defasciculation of motor neuron axon [GO:0007415]; motor neuron axon guidance [GO:0008045]; protein dephosphorylation [GO:0006470]; regulation of glucose metabolic process [GO:0010906] GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007414; GO:0007415; GO:0008045; GO:0010906; GO:0016021; GO:0030424 0 0 0 PF00041;PF00102; P35832 CHOYP_LOC660278.2.2 m.22516 sp PTP99_DROME 40.779 873 467 18 394 1248 170 1010 0 636 PTP99_DROME reviewed Tyrosine-protein phosphatase 99A (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 99A) (DPTP99A) Ptp99A CG2005 Drosophila melanogaster (Fruit fly) 1301 axonal defasciculation [GO:0007414]; defasciculation of motor neuron axon [GO:0007415]; motor neuron axon guidance [GO:0008045]; protein dephosphorylation [GO:0006470]; regulation of glucose metabolic process [GO:0010906] GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007414; GO:0007415; GO:0008045; GO:0010906; GO:0016021; GO:0030424 0 0 0 PF00041;PF00102; P35992 CHOYP_PTPRB.2.4 m.24255 sp PTP10_DROME 31.354 1499 881 48 307 1742 145 1558 0 607 PTP10_DROME reviewed Tyrosine-protein phosphatase 10D (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 10D) (DPTP10D) Ptp10D CG1817 Drosophila melanogaster (Fruit fly) 1990 axon guidance [GO:0007411]; central nervous system development [GO:0007417]; long-term memory [GO:0007616]; motor neuron axon guidance [GO:0008045]; open tracheal system development [GO:0007424]; protein dephosphorylation [GO:0006470] GO:0004721; GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007411; GO:0007417; GO:0007424; GO:0007616; GO:0008045; GO:0016021; GO:0030424; GO:0045177 0 0 0 PF00041;PF00102; P36406 CHOYP_TRI23.4.7 m.33527 sp TRI23_HUMAN 59.965 577 227 2 11 586 1 574 0 719 TRI23_HUMAN reviewed E3 ubiquitin-protein ligase TRIM23 (EC 6.3.2.-) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23) TRIM23 ARD1 ARFD1 RNF46 Homo sapiens (Human) 574 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264]; viral process [GO:0016032] GO:0000139; GO:0003924; GO:0004842; GO:0005525; GO:0005634; GO:0005765; GO:0007264; GO:0008047; GO:0008270; GO:0016032; GO:0016567; GO:0016874; GO:0019003; GO:0042802; GO:0070062 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF14634; P36871 CHOYP_PGM1.1.1 m.38482 sp PGM1_HUMAN 64.337 558 193 4 6 557 5 562 0 757 PGM1_HUMAN reviewed Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1) PGM1 Homo sapiens (Human) 562 galactose catabolic process [GO:0019388]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; glycolytic process [GO:0006096] GO:0000287; GO:0004614; GO:0005737; GO:0005829; GO:0005978; GO:0005980; GO:0006006; GO:0006094; GO:0006096; GO:0015629; GO:0019388; GO:0070062 0 0 0 PF02878;PF02879;PF02880;PF00408; P36876 CHOYP_LOC100567969.1.1 m.26460 sp 2ABA_RAT 82.619 443 76 1 2 444 4 445 0 776 2ABA_RAT reviewed Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PP2A subunit B isoform B55-alpha) (PP2A subunit B isoform BRA) (PP2A subunit B isoform PR55-alpha) (PP2A subunit B isoform R2-alpha) (PP2A subunit B isoform alpha) Ppp2r2a Rattus norvegicus (Rat) 447 response to morphine [GO:0043278] GO:0000159; GO:0004722; GO:0008601; GO:0032403; GO:0043278; GO:0048156; GO:0051721 0 0 0 0 P36916 CHOYP_GNL1.1.1 m.56558 sp GNL1_MOUSE 51.009 545 218 8 1 502 1 539 0 529 GNL1_MOUSE reviewed Guanine nucleotide-binding protein-like 1 (GTP-binding protein MMR1) Gnl1 Gna-rs1 Mmr1 Mus musculus (Mouse) 607 cellular response to DNA damage stimulus [GO:0006974]; ribosome biogenesis [GO:0042254] GO:0003924; GO:0005525; GO:0005634; GO:0006974; GO:0042254 0 0 0 PF01926; P36956 CHOYP_BRAFLDRAFT_117231.1.1 m.4966 sp SRBP1_HUMAN 39.887 885 455 20 345 1160 262 1138 0 580 SRBP1_HUMAN reviewed Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1] SREBF1 BHLHD1 SREBP1 Homo sapiens (Human) 1147 aging [GO:0007568]; cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; cholesterol metabolic process [GO:0008203]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; mRNA transcription from RNA polymerase II promoter [GO:0042789]; negative regulation of insulin secretion [GO:0046676]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by chemical signal [GO:0003062]; regulation of mitophagy [GO:1903146]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to cAMP [GO:0051591]; response to drug [GO:0042493]; response to food [GO:0032094]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526] GO:0000122; GO:0000139; GO:0000978; GO:0001077; GO:0003062; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0006357; GO:0006629; GO:0007568; GO:0007623; GO:0008203; GO:0008286; GO:0008610; GO:0009267; GO:0009749; GO:0010867; GO:0012507; GO:0016021; GO:0019217; GO:0030324; GO:0031065; GO:0031647; GO:0032094; GO:0032526; GO:0032570; GO:0032810; GO:0033762; GO:0042493; GO:0042789; GO:0043234; GO:0045444; GO:0045542; GO:0045944; GO:0046676; GO:0051591; GO:0071398; GO:1903146; GO:1903214 0 0 0 PF00010; P37287 CHOYP_PIGA.1.1 m.66221 sp PIGA_HUMAN 63.318 428 150 5 3 427 33 456 0 553 PIGA_HUMAN reviewed Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A) PIGA Homo sapiens (Human) 484 GPI anchor biosynthetic process [GO:0006506]; positive regulation of metabolic process [GO:0009893]; preassembly of GPI anchor in ER membrane [GO:0016254] GO:0000506; GO:0005789; GO:0006506; GO:0008194; GO:0009893; GO:0016020; GO:0016021; GO:0016254; GO:0017176 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF00534;PF08288; P37880 CHOYP_SYRC.1.2 m.36309 sp SYRC_CRIGR 65.031 652 221 3 13 661 14 661 0 902 SYRC_CRIGR reviewed "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS RRS1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 661 arginyl-tRNA aminoacylation [GO:0006420] GO:0004814; GO:0005524; GO:0005737; GO:0006420 0 0 0 PF03485;PF05746;PF00750; P38024 CHOYP_BRAFLDRAFT_117612.1.1 m.28286 sp PUR6_CHICK 64.439 419 148 1 2 419 4 422 0 580 PUR6_CHICK reviewed Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)] AIRC Gallus gallus (Chicken) 426 'de novo' IMP biosynthetic process [GO:0006189]; adenine biosynthetic process [GO:0046084] GO:0004638; GO:0004639; GO:0005524; GO:0005829; GO:0006189; GO:0016020; GO:0046084; GO:0070062 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1. 0 0 PF00731;PF01259; P38024 CHOYP_PUR1.1.1 m.16523 sp PUR6_CHICK 64.2 419 149 1 2 419 4 422 0 576 PUR6_CHICK reviewed Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)] AIRC Gallus gallus (Chicken) 426 'de novo' IMP biosynthetic process [GO:0006189]; adenine biosynthetic process [GO:0046084] GO:0004638; GO:0004639; GO:0005524; GO:0005829; GO:0006189; GO:0016020; GO:0046084; GO:0070062 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1. 0 0 PF00731;PF01259; P38606 CHOYP_VATA.1.1 m.44460 sp VATA_HUMAN 85.481 613 89 0 26 638 5 617 0 1096 VATA_HUMAN reviewed V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 3.6.3.14) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) ATP6V1A ATP6A1 ATP6V1A1 VPP2 Homo sapiens (Human) 617 ATP hydrolysis coupled proton transport [GO:0015991]; ATP metabolic process [GO:0046034]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; phagosome acidification [GO:0090383]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]; transport [GO:0006810] GO:0005524; GO:0005739; GO:0005765; GO:0005829; GO:0005886; GO:0005887; GO:0005902; GO:0006810; GO:0008286; GO:0015991; GO:0016241; GO:0016324; GO:0016469; GO:0033180; GO:0033572; GO:0034220; GO:0043209; GO:0046034; GO:0046961; GO:0070062; GO:0090383 0 0 0 PF00006;PF02874;PF16886; P39087 CHOYP_AGAP_AGAP000801.1.1 m.62492 sp GRIK2_MOUSE 38.882 859 482 16 31 869 52 887 0 627 GRIK2_MOUSE reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Glutamate receptor beta-2) (GluR beta-2)" Grik2 Glur6 Mus musculus (Mouse) 908 "behavioral fear response [GO:0001662]; cellular calcium ion homeostasis [GO:0006874]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; intracellular protein transport [GO:0006886]; modulation of synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuronal action potential [GO:0019228]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of membrane potential [GO:0042391]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]" GO:0001662; GO:0004970; GO:0005234; GO:0006874; GO:0006886; GO:0007268; GO:0008328; GO:0014069; GO:0015277; GO:0016020; GO:0019228; GO:0030054; GO:0032839; GO:0032983; GO:0035249; GO:0042391; GO:0042734; GO:0043025; GO:0043113; GO:0043195; GO:0043204; GO:0043524; GO:0043525; GO:0045202; GO:0045211; GO:0046328; GO:0048169; GO:0048172; GO:0050804; GO:0050806; GO:0051402; GO:0051967; GO:0060079; GO:0060080 0 0 0 PF01094;PF00060;PF10613; P39087 CHOYP_GRIK2.2.3 m.35763 sp GRIK2_MOUSE 44.37 897 447 16 8 878 2 872 0 770 GRIK2_MOUSE reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Glutamate receptor beta-2) (GluR beta-2)" Grik2 Glur6 Mus musculus (Mouse) 908 "behavioral fear response [GO:0001662]; cellular calcium ion homeostasis [GO:0006874]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; intracellular protein transport [GO:0006886]; modulation of synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuronal action potential [GO:0019228]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of membrane potential [GO:0042391]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]" GO:0001662; GO:0004970; GO:0005234; GO:0006874; GO:0006886; GO:0007268; GO:0008328; GO:0014069; GO:0015277; GO:0016020; GO:0019228; GO:0030054; GO:0032839; GO:0032983; GO:0035249; GO:0042391; GO:0042734; GO:0043025; GO:0043113; GO:0043195; GO:0043204; GO:0043524; GO:0043525; GO:0045202; GO:0045211; GO:0046328; GO:0048169; GO:0048172; GO:0050804; GO:0050806; GO:0051402; GO:0051967; GO:0060079; GO:0060080 0 0 0 PF01094;PF00060;PF10613; P39098 CHOYP_LOC100376162.1.1 m.48261 sp MA1A2_MOUSE 53.532 637 264 8 5 625 6 626 0 687 MA1A2_MOUSE reviewed "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Mannosidase alpha class 1A member 2) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB)" Man1a2 Man1b Mus musculus (Mouse) 641 glycoprotein metabolic process [GO:0009100]; lung alveolus development [GO:0048286]; N-glycan processing [GO:0006491]; respiratory gaseous exchange [GO:0007585] GO:0000139; GO:0004571; GO:0005509; GO:0005783; GO:0005794; GO:0006491; GO:0007585; GO:0009100; GO:0016020; GO:0016021; GO:0048286; GO:0070062 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P32906}. 0 0 PF01532; P39872 CHOYP_LOC660560.1.4 m.31036 sp RL3_BOVIN 76.864 389 88 1 1 387 15 403 0 647 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; P39872 CHOYP_LOC660560.2.4 m.40911 sp RL3_BOVIN 77.419 403 89 1 1 401 1 403 0 674 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; P39872 CHOYP_RL3.7.7 m.57414 sp RL3_BOVIN 76.656 317 71 1 1 314 1 317 0 522 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; P40122 CHOYP_CAP.1.2 m.22123 sp CAP_HYDVD 57.563 476 191 5 1 471 11 480 0 536 CAP_HYDVD reviewed Adenylyl cyclase-associated protein (CAP) CAP Hydra viridissima (Green hydra) (Chlorohydra viridissima) 481 cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010] GO:0000902; GO:0005886; GO:0007010 0 0 0 PF08603;PF01213; P40927 CHOYP_ME3.1.1 m.58433 sp MAOX_COLLI 62.025 553 205 3 56 607 3 551 0 730 MAOX_COLLI reviewed NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) ME1 Columba livia (Rock dove) 557 malate metabolic process [GO:0006108] GO:0004471; GO:0004473; GO:0005737; GO:0006108; GO:0008948; GO:0046872; GO:0051287 0 0 0 PF00390;PF03949; P40939 CHOYP_LOC100703423.1.1 m.940 sp ECHA_HUMAN 60.904 752 286 7 11 759 16 762 0 932 ECHA_HUMAN reviewed "Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]" HADHA HADH Homo sapiens (Human) 763 cardiolipin acyl-chain remodeling [GO:0035965]; fatty acid beta-oxidation [GO:0006635]; response to drug [GO:0042493]; response to insulin [GO:0032868] GO:0000062; GO:0003857; GO:0003985; GO:0004300; GO:0005739; GO:0005743; GO:0006635; GO:0016507; GO:0016508; GO:0016509; GO:0031012; GO:0032868; GO:0035965; GO:0042493; GO:0042645; GO:0051287 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00725;PF02737;PF00378; P41233 CHOYP_ABCA1.1.3 m.6501 sp ABCA1_MOUSE 38.156 1638 841 36 1 1585 1 1519 0 1028 ABCA1_MOUSE reviewed ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 Mus musculus (Mouse) 2261 "cellular response to cholesterol [GO:0071397]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; G-protein coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; interleukin-1 beta secretion [GO:0050702]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cholesterol efflux [GO:0010875]; protein lipidation [GO:0006497]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to drug [GO:0042493]; response to laminar fluid shear stress [GO:0034616]; response to low-density lipoprotein particle [GO:0055098]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]" GO:0002790; GO:0005102; GO:0005524; GO:0005548; GO:0005794; GO:0005886; GO:0005887; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007584; GO:0008203; GO:0008509; GO:0009897; GO:0010875; GO:0016197; GO:0017127; GO:0019905; GO:0030139; GO:0030819; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034364; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042493; GO:0042626; GO:0042632; GO:0043231; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0048471; GO:0050702; GO:0051117; GO:0055091; GO:0055098; GO:0060155; GO:0071222; GO:0071300; GO:0071397 0 0 0 PF00005; P41233 CHOYP_ABCA1.3.3 m.56453 sp ABCA1_MOUSE 44.742 2387 1108 44 1 2333 1 2230 0 1894 ABCA1_MOUSE reviewed ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 Mus musculus (Mouse) 2261 "cellular response to cholesterol [GO:0071397]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; G-protein coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; interleukin-1 beta secretion [GO:0050702]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cholesterol efflux [GO:0010875]; protein lipidation [GO:0006497]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to drug [GO:0042493]; response to laminar fluid shear stress [GO:0034616]; response to low-density lipoprotein particle [GO:0055098]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]" GO:0002790; GO:0005102; GO:0005524; GO:0005548; GO:0005794; GO:0005886; GO:0005887; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007584; GO:0008203; GO:0008509; GO:0009897; GO:0010875; GO:0016197; GO:0017127; GO:0019905; GO:0030139; GO:0030819; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034364; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042493; GO:0042626; GO:0042632; GO:0043231; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0048471; GO:0050702; GO:0051117; GO:0055091; GO:0055098; GO:0060155; GO:0071222; GO:0071300; GO:0071397 0 0 0 PF00005; P41233 CHOYP_ABCA4.1.1 m.31461 sp ABCA1_MOUSE 32.825 2163 1250 37 3010 5009 104 2226 0 1177 ABCA1_MOUSE reviewed ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 Mus musculus (Mouse) 2261 "cellular response to cholesterol [GO:0071397]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; G-protein coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; interleukin-1 beta secretion [GO:0050702]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cholesterol efflux [GO:0010875]; protein lipidation [GO:0006497]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to drug [GO:0042493]; response to laminar fluid shear stress [GO:0034616]; response to low-density lipoprotein particle [GO:0055098]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]" GO:0002790; GO:0005102; GO:0005524; GO:0005548; GO:0005794; GO:0005886; GO:0005887; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007584; GO:0008203; GO:0008509; GO:0009897; GO:0010875; GO:0016197; GO:0017127; GO:0019905; GO:0030139; GO:0030819; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034364; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042493; GO:0042626; GO:0042632; GO:0043231; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0048471; GO:0050702; GO:0051117; GO:0055091; GO:0055098; GO:0060155; GO:0071222; GO:0071300; GO:0071397 0 0 0 PF00005; P41233 CHOYP_TRIADDRAFT_10137.1.1 m.9874 sp ABCA1_MOUSE 55.891 662 285 3 34 694 1571 2226 0 802 ABCA1_MOUSE reviewed ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 Mus musculus (Mouse) 2261 "cellular response to cholesterol [GO:0071397]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; G-protein coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; interleukin-1 beta secretion [GO:0050702]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cholesterol efflux [GO:0010875]; protein lipidation [GO:0006497]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to drug [GO:0042493]; response to laminar fluid shear stress [GO:0034616]; response to low-density lipoprotein particle [GO:0055098]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]" GO:0002790; GO:0005102; GO:0005524; GO:0005548; GO:0005794; GO:0005886; GO:0005887; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007584; GO:0008203; GO:0008509; GO:0009897; GO:0010875; GO:0016197; GO:0017127; GO:0019905; GO:0030139; GO:0030819; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034364; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042493; GO:0042626; GO:0042632; GO:0043231; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0048471; GO:0050702; GO:0051117; GO:0055091; GO:0055098; GO:0060155; GO:0071222; GO:0071300; GO:0071397 0 0 0 PF00005; P41252 CHOYP_IARS.1.1 m.27559 sp SYIC_HUMAN 60.472 1270 462 12 1 1260 1 1240 0 1608 SYIC_HUMAN reviewed "Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)" IARS Homo sapiens (Human) 1262 isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418] GO:0000049; GO:0001649; GO:0002161; GO:0004822; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0006418; GO:0006428; GO:0016020; GO:0051020; GO:0070062 0 0 cd07961; PF08264;PF00133; P41340 CHOYP_ACT3.1.3 m.23292 sp ACT3_LIMPO 97.328 262 7 0 24 285 115 376 0 536 ACT3_LIMPO reviewed Actin-3 0 Limulus polyphemus (Atlantic horseshoe crab) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P41383 CHOYP_TBA1.1.9 m.2156 sp TBA2_PATVU 97.339 451 12 0 32 482 2 452 0 932 TBA2_PATVU reviewed Tubulin alpha-2/alpha-4 chain TUB2; TUB4 Patella vulgata (Common limpet) 452 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P41387 CHOYP_TBB2.2.2 m.53000 sp TBB_ONCGI 77.027 444 102 0 1 444 1 444 0 719 TBB_ONCGI reviewed Tubulin beta chain (Beta-tubulin) TBB Onchocerca gibsoni 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P41823 CHOYP_SY65.1.1 m.62498 sp SY65_APLCA 71.363 433 116 6 8 440 4 428 0 579 SY65_APLCA reviewed Synaptotagmin-1 (Synaptotagmin I) (p65) SYT1 Aplysia californica (California sea hare) 428 negative regulation of calcium ion-dependent exocytosis [GO:0045955]; synaptic vesicle exocytosis [GO:0016079] GO:0000149; GO:0005509; GO:0016079; GO:0030054; GO:0030285; GO:0045955 0 0 0 PF00168; P41827 CHOYP_HSP70.1.1 m.61727 sp HSP74_ANOAL 75.705 638 144 3 7 634 4 640 0 1030 HSP74_ANOAL reviewed Heat shock protein 70 B2 HSP70B2 HSP11-C-L Anopheles albimanus (New world malaria mosquito) 640 0 GO:0005524 0 0 0 PF00012; P41827 CHOYP_HSP74.1.1 m.13095 sp HSP74_ANOAL 75.824 637 145 2 7 634 4 640 0 1023 HSP74_ANOAL reviewed Heat shock protein 70 B2 HSP70B2 HSP11-C-L Anopheles albimanus (New world malaria mosquito) 640 0 GO:0005524 0 0 0 PF00012; P41827 CHOYP_HSP7D.1.3 m.18061 sp HSP74_ANOAL 77.282 515 105 2 7 517 4 510 0 839 HSP74_ANOAL reviewed Heat shock protein 70 B2 HSP70B2 HSP11-C-L Anopheles albimanus (New world malaria mosquito) 640 0 GO:0005524 0 0 0 PF00012; P41937 CHOYP_TBB2.1.2 m.45096 sp TBB4_CAEEL 76.244 442 103 1 1 440 1 442 0 716 TBB4_CAEEL reviewed Tubulin beta-4 chain (Beta-4-tubulin) tbb-4 B0272.1 Caenorhabditis elegans 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005879; GO:0007017 0 0 0 PF00091;PF03953; P42260 CHOYP_GRIK1.1.1 m.928 sp GRIK2_RAT 38.225 845 476 15 57 880 57 876 0 590 GRIK2_RAT reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" Grik2 Glur6 Rattus norvegicus (Rat) 908 "behavioral fear response [GO:0001662]; cellular calcium ion homeostasis [GO:0006874]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; intracellular protein transport [GO:0006886]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuronal action potential [GO:0019228]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]" GO:0001662; GO:0004970; GO:0005234; GO:0005887; GO:0006874; GO:0006886; GO:0007268; GO:0008066; GO:0008328; GO:0014069; GO:0015277; GO:0019228; GO:0030054; GO:0030165; GO:0030424; GO:0030425; GO:0031624; GO:0031625; GO:0032839; GO:0032983; GO:0035249; GO:0042734; GO:0042802; GO:0042803; GO:0043113; GO:0043195; GO:0043204; GO:0043524; GO:0043525; GO:0045202; GO:0045211; GO:0046328; GO:0048169; GO:0048172; GO:0050806; GO:0051402; GO:0051967; GO:0060079; GO:0060080 0 0 0 PF01094;PF00060;PF10613; P42285 CHOYP_SK2L2.1.1 m.35679 sp SK2L2_HUMAN 71.565 1048 269 7 1 1025 1 1042 0 1566 SK2L2_HUMAN reviewed Superkiller viralicidic activity 2-like 2 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (TRAMP-like complex helicase) SKIV2L2 DOB1 KIAA0052 Mtr4 Homo sapiens (Human) 1042 "maturation of 5.8S rRNA [GO:0000460]; mRNA splicing, via spliceosome [GO:0000398]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]" GO:0000398; GO:0000460; GO:0003724; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006364; GO:0006401; GO:0044822; GO:0071013 0 0 0 PF00270;PF08148;PF00271;PF13234; P42345 CHOYP_MTOR.2.2 m.51573 sp MTOR_HUMAN 64.88 2537 818 16 8 2479 21 2549 0 3351 MTOR_HUMAN reviewed Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1) MTOR FRAP FRAP1 FRAP2 RAFT1 RAPT1 Homo sapiens (Human) 2549 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; brain development [GO:0007420]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cell aging [GO:0007569]; cell cycle arrest [GO:0007050]; cell growth [GO:0016049]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; DNA repair [GO:0006281]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; growth [GO:0040007]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; long-term memory [GO:0007616]; macroautophagy [GO:0016236]; maternal process involved in female pregnancy [GO:0060135]; mRNA stabilization [GO:0048255]; multicellular organism growth [GO:0035264]; negative regulation of autophagy [GO:0010507]; negative regulation of cell size [GO:0045792]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of iodide transmembrane transport [GO:1904213]; negative regulation of macroautophagy [GO:0016242]; negative regulation of muscle atrophy [GO:0014736]; negative regulation of NFAT protein import into nucleus [GO:0051534]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of eating behavior [GO:1904000]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of granulosa cell proliferation [GO:1904197]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron maturation [GO:0014042]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of sensory perception of pain [GO:1904058]; positive regulation of skeletal muscle hypertrophy [GO:1904206]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription from RNA polymerase III promoter [GO:0045945]; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901838]; positive regulation of translation [GO:0045727]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of brown fat cell differentiation [GO:0090335]; regulation of carbohydrate utilization [GO:0043610]; regulation of cellular response to heat [GO:1900034]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of GTPase activity [GO:0043087]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of protein kinase activity [GO:0045859]; regulation of response to food [GO:0032095]; response to amino acid [GO:0043200]; response to cocaine [GO:0042220]; response to insulin [GO:0032868]; response to morphine [GO:0043278]; response to nutrient [GO:0007584]; response to stress [GO:0006950]; ruffle organization [GO:0031529]; signal transduction [GO:0007165]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; T cell costimulation [GO:0031295]; TOR signaling [GO:0031929]; visual learning [GO:0008542]; voluntary musculoskeletal movement [GO:0050882]; wound healing [GO:0042060] GO:0000139; GO:0001030; GO:0001031; GO:0001032; GO:0001156; GO:0001933; GO:0001934; GO:0001938; GO:0003007; GO:0003179; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005741; GO:0005764; GO:0005765; GO:0005789; GO:0005829; GO:0005942; GO:0005979; GO:0006112; GO:0006207; GO:0006281; GO:0006468; GO:0006950; GO:0007050; GO:0007165; GO:0007281; GO:0007420; GO:0007569; GO:0007584; GO:0007616; GO:0008542; GO:0009791; GO:0010507; GO:0010592; GO:0010628; GO:0010831; GO:0012505; GO:0014042; GO:0014736; GO:0016020; GO:0016049; GO:0016236; GO:0016242; GO:0016301; GO:0016310; GO:0016605; GO:0018105; GO:0018107; GO:0021510; GO:0030163; GO:0030425; GO:0030838; GO:0031295; GO:0031397; GO:0031529; GO:0031641; GO:0031669; GO:0031929; GO:0031931; GO:0031932; GO:0031998; GO:0032095; GO:0032868; GO:0032956; GO:0035176; GO:0035264; GO:0040007; GO:0042060; GO:0042220; GO:0043022; GO:0043025; GO:0043087; GO:0043200; GO:0043278; GO:0043610; GO:0045429; GO:0045670; GO:0045727; GO:0045792; GO:0045859; GO:0045945; GO:0046777; GO:0046889; GO:0048015; GO:0048255; GO:0048661; GO:0048714; GO:0050731; GO:0050882; GO:0051219; GO:0051496; GO:0051534; GO:0051897; GO:0055013; GO:0060048; GO:0060135; GO:0060252; GO:0060999; GO:0061051; GO:0071456; GO:0090335; GO:0090559; GO:1900034; GO:1901216; GO:1901838; GO:1904000; GO:1904056; GO:1904058; GO:1904193; GO:1904197; GO:1904206; GO:1904213 0 0 0 PF11865;PF02259;PF02260;PF08771;PF00454; P42680 CHOYP_BTKL.1.1 m.55271 sp TEC_HUMAN 48.019 631 295 14 6 617 8 624 0 571 TEC_HUMAN reviewed Tyrosine-protein kinase Tec (EC 2.7.10.2) TEC PSCTK4 Homo sapiens (Human) 631 adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; cell differentiation [GO:0030154]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; regulation of platelet activation [GO:0010543]; tissue regeneration [GO:0042246]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0002250; GO:0004715; GO:0005524; GO:0005543; GO:0005829; GO:0005856; GO:0006468; GO:0007169; GO:0007229; GO:0010543; GO:0018108; GO:0030154; GO:0031234; GO:0035556; GO:0038083; GO:0038095; GO:0042127; GO:0042246; GO:0045087; GO:0046872; GO:0050731; GO:0050853 0 0 0 PF00779;PF00169;PF07714;PF00017;PF00018; P42695 CHOYP_LOC100367618.1.1 m.14341 sp CNDD3_HUMAN 35.174 1612 860 38 42 1616 17 1480 0 867 CNDD3_HUMAN reviewed Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) NCAPD3 CAPD3 KIAA0056 Homo sapiens (Human) 1498 cell division [GO:0051301]; chromosome separation [GO:0051304]; meiotic chromosome condensation [GO:0010032]; mitotic chromosome condensation [GO:0007076] GO:0000779; GO:0000799; GO:0003682; GO:0005654; GO:0007076; GO:0010032; GO:0016020; GO:0031618; GO:0035064; GO:0051301; GO:0051304 0 0 0 PF12717; P42859 CHOYP_HD.1.1 m.56119 sp HD_MOUSE 43.762 2132 1079 37 6 2070 1036 3114 0 1703 HD_MOUSE reviewed Huntingtin (Huntington disease protein homolog) (HD protein homolog) Htt Hd Hdh Mus musculus (Mouse) 3119 "anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; associative learning [GO:0008306]; axo-dendritic transport [GO:0008088]; brain development [GO:0007420]; cell aging [GO:0007569]; central nervous system development [GO:0007417]; citrulline metabolic process [GO:0000052]; determination of adult lifespan [GO:0008340]; dopamine receptor signaling pathway [GO:0007212]; endoplasmic reticulum organization [GO:0007029]; endosomal transport [GO:0016197]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insulin secretion [GO:0030073]; iron ion homeostasis [GO:0055072]; lactate biosynthetic process from pyruvate [GO:0019244]; learning [GO:0007612]; learning or memory [GO:0007611]; L-glutamate import [GO:0051938]; locomotory behavior [GO:0007626]; mitochondrial transport [GO:0006839]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron death [GO:1901215]; neural plate formation [GO:0021990]; neurogenesis [GO:0022008]; neuron apoptotic process [GO:0051402]; neuron development [GO:0048666]; olfactory lobe development [GO:0021988]; paraxial mesoderm formation [GO:0048341]; peptide hormone secretion [GO:0030072]; positive regulation of cilium assembly [GO:0045724]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nonmotile primary cilium assembly [GO:1902857]; protein import into nucleus [GO:0006606]; protein localization to centrosome [GO:0071539]; quinolinate biosynthetic process [GO:0019805]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of protein phosphatase type 2A activity [GO:0034047]; regulation of synaptic plasticity [GO:0048167]; response to calcium ion [GO:0051592]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; social behavior [GO:0035176]; spermatogenesis [GO:0007283]; striatum development [GO:0021756]; urea cycle [GO:0000050]; vesicle transport along microtubule [GO:0047496]; visual learning [GO:0008542]; vocal learning [GO:0042297]" GO:0000050; GO:0000052; GO:0000132; GO:0002039; GO:0005522; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005770; GO:0005776; GO:0005783; GO:0005794; GO:0005814; GO:0005829; GO:0006606; GO:0006839; GO:0006888; GO:0006890; GO:0006915; GO:0007005; GO:0007029; GO:0007030; GO:0007212; GO:0007283; GO:0007369; GO:0007417; GO:0007420; GO:0007569; GO:0007611; GO:0007612; GO:0007625; GO:0007626; GO:0008088; GO:0008134; GO:0008306; GO:0008340; GO:0008542; GO:0009653; GO:0009952; GO:0016023; GO:0016197; GO:0016234; GO:0019244; GO:0019805; GO:0021756; GO:0021988; GO:0021990; GO:0022008; GO:0030072; GO:0030073; GO:0030424; GO:0030425; GO:0030659; GO:0031587; GO:0034047; GO:0034452; GO:0035176; GO:0042297; GO:0042445; GO:0042802; GO:0043066; GO:0043234; GO:0043524; GO:0044325; GO:0045505; GO:0045724; GO:0046902; GO:0047496; GO:0048167; GO:0048341; GO:0048487; GO:0048666; GO:0050809; GO:0051402; GO:0051592; GO:0051881; GO:0051938; GO:0055072; GO:0071539; GO:1901215; GO:1902857; GO:2001237 0 0 0 PF12372; P43006 CHOYP_TBB4B.3.7 m.22777 sp EAA2_MOUSE 52.11 545 218 10 35 570 26 536 0 525 EAA2_MOUSE reviewed Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Slc1a2 Eaat2 Glt1 Mus musculus (Mouse) 572 adult behavior [GO:0030534]; anion transmembrane transport [GO:0098656]; cellular response to extracellular stimulus [GO:0031668]; D-aspartate import [GO:0070779]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0089711]; L-glutamate transport [GO:0015813]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; positive regulation of glucose import [GO:0046326]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; telencephalon development [GO:0021537]; visual behavior [GO:0007632] GO:0005313; GO:0005886; GO:0005887; GO:0007399; GO:0007632; GO:0008509; GO:0009416; GO:0009611; GO:0009986; GO:0010259; GO:0015501; GO:0015813; GO:0021537; GO:0030424; GO:0030534; GO:0030673; GO:0031668; GO:0035264; GO:0042493; GO:0043200; GO:0046326; GO:0051938; GO:0070779; GO:0089711; GO:0098656 0 0 0 PF00375; P43249 CHOYP_GRK5.1.1 m.6617 sp GRK5_BOVIN 68.375 566 170 3 1 563 1 560 0 788 GRK5_BOVIN reviewed G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5) GRK5 GPRK5 Bos taurus (Bovine) 590 apoptotic process [GO:0006915]; fat cell differentiation [GO:0045444]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell proliferation [GO:0008284]; protein autophosphorylation [GO:0046777]; regulation of cell cycle [GO:0051726]; tachykinin receptor signaling pathway [GO:0007217]; Wnt signaling pathway [GO:0016055] GO:0004674; GO:0004703; GO:0005524; GO:0005737; GO:0005886; GO:0005925; GO:0006915; GO:0007217; GO:0008284; GO:0008289; GO:0016055; GO:0031965; GO:0043066; GO:0045444; GO:0046777; GO:0047696; GO:0051726 0 0 0 PF00069;PF00615; P45844 CHOYP_ABCG1.1.1 m.11044 sp ABCG1_HUMAN 61.256 653 209 9 45 693 66 678 0 771 ABCG1_HUMAN reviewed ATP-binding cassette sub-family G member 1 (ATP-binding cassette transporter 8) (White protein homolog) ABCG1 ABC8 WHT1 Homo sapiens (Human) 678 "amyloid precursor protein catabolic process [GO:0042987]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; detection of hormone stimulus [GO:0009720]; glycoprotein transport [GO:0034436]; high-density lipoprotein particle remodeling [GO:0034375]; intracellular cholesterol transport [GO:0032367]; lipoprotein metabolic process [GO:0042157]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of cholesterol efflux [GO:0010875]; regulation of cholesterol esterification [GO:0010872]; regulation of transcription, DNA-templated [GO:0006355]; response to high density lipoprotein particle [GO:0055099]; response to lipid [GO:0033993]; response to organic substance [GO:0010033]; reverse cholesterol transport [GO:0043691]; transmembrane transport [GO:0055085]" GO:0000139; GO:0005524; GO:0005543; GO:0005548; GO:0005654; GO:0005739; GO:0005768; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0006355; GO:0008203; GO:0009720; GO:0009897; GO:0010033; GO:0010745; GO:0010872; GO:0010875; GO:0010887; GO:0015485; GO:0016021; GO:0017127; GO:0019534; GO:0032367; GO:0033344; GO:0033700; GO:0033993; GO:0034041; GO:0034374; GO:0034375; GO:0034436; GO:0034437; GO:0042157; GO:0042632; GO:0042803; GO:0042987; GO:0043231; GO:0043531; GO:0043691; GO:0045542; GO:0046982; GO:0046983; GO:0055037; GO:0055085; GO:0055091; GO:0055099 0 0 0 PF01061;PF00005; P45885 CHOYP_ACT1.2.7 m.25796 sp ACT2_BACDO 81.967 366 65 1 4 368 3 368 0 636 ACT2_BACDO reviewed "Actin-2, muscle-specific" 0 Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P45954 CHOYP_LOC100692418.1.1 m.55157 sp ACDSB_HUMAN 65.963 379 129 0 59 437 53 431 0 542 ACDSB_HUMAN reviewed "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial (SBCAD) (EC 1.3.8.5) (2-methyl branched chain acyl-CoA dehydrogenase) (2-MEBCAD) (2-methylbutyryl-coenzyme A dehydrogenase) (2-methylbutyryl-CoA dehydrogenase)" ACADSB Homo sapiens (Human) 432 branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty acid metabolic process [GO:0006631]; lipid homeostasis [GO:0055088] GO:0000062; GO:0003995; GO:0005739; GO:0005759; GO:0006631; GO:0009055; GO:0009083; GO:0033539; GO:0050660; GO:0052890; GO:0055088; GO:0070062 PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. 0 0 PF00441;PF02770;PF02771; P46023 CHOYP_GR101.3.3 m.43507 sp GR101_LYMST 43.494 807 420 17 18 811 12 795 0 630 GR101_LYMST reviewed G-protein coupled receptor GRL101 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 1115 0 GO:0005886; GO:0016021; GO:0016500 0 0 0 PF00001;PF00057;PF12799;PF13855; P46461 CHOYP_BRAFLDRAFT_118310.1.1 m.8287 sp NSF1_DROME 64.286 742 263 2 1 741 1 741 0 990 NSF1_DROME reviewed Vesicle-fusing ATPase 1 (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein 1) (NEM-sensitive fusion protein 1) (Protein comatose) (Vesicular-fusion protein NSF1) (dNsf-1) (NSF-1) comt Nsf Nsf1 CG1618 Drosophila melanogaster (Fruit fly) 745 Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle docking [GO:0048211]; intra-Golgi vesicle-mediated transport [GO:0006891]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter secretion [GO:0007269]; phagocytosis [GO:0006909]; regulation of neuromuscular synaptic transmission [GO:1900073]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; SNARE complex disassembly [GO:0035494]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082] GO:0005524; GO:0005737; GO:0005795; GO:0006891; GO:0006909; GO:0007030; GO:0007269; GO:0007274; GO:0016082; GO:0016887; GO:0031629; GO:0032403; GO:0035494; GO:0043001; GO:0043195; GO:0046872; GO:0048172; GO:0048211; GO:0098527; GO:1900073 0 0 0 PF00004;PF02933;PF02359; P46530 CHOYP_LOC100366518.3.6 m.34987 sp NOTC1_DANRE 37.438 1015 551 19 201 1155 236 1226 0 612 NOTC1_DANRE reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1a notch Danio rerio (Zebrafish) (Brachydanio rerio) 2437 "angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; dorsal aorta development [GO:0035907]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; habenula development [GO:0021986]; hematopoietic progenitor cell differentiation [GO:0002244]; hypochord development [GO:0055016]; negative regulation of neurogenesis [GO:0050768]; neural plate development [GO:0001840]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; pancreas development [GO:0031016]; peripheral nervous system neuron axonogenesis [GO:0048936]; positive regulation of mesodermal cell fate specification [GO:0048337]; regulation of endodermal cell fate specification [GO:0042663]; regulation of receptor-mediated endocytosis [GO:0048259]; regulation of transcription, DNA-templated [GO:0006355]; somatic motor neuron differentiation [GO:0021523]; somitogenesis [GO:0001756]; spinal cord radial glial cell differentiation [GO:0021531]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron differentiation [GO:0021514]" GO:0001525; GO:0001756; GO:0001840; GO:0002244; GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0007219; GO:0007368; GO:0009952; GO:0016021; GO:0021514; GO:0021523; GO:0021531; GO:0021986; GO:0031016; GO:0031017; GO:0035907; GO:0042663; GO:0048259; GO:0048337; GO:0048699; GO:0048936; GO:0050768; GO:0055016; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P46735 CHOYP_MYO1B.1.1 m.53598 sp MYO1B_MOUSE 52.291 1113 483 10 1 1080 1 1098 0 1159 MYO1B_MOUSE reviewed Unconventional myosin-Ib (MIH-L) (Myosin I alpha) (MMI-alpha) (MMIa) Myo1b Mus musculus (Mouse) 1107 actin filament-based movement [GO:0030048]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; post-Golgi vesicle-mediated transport [GO:0006892] GO:0000146; GO:0005524; GO:0005546; GO:0005547; GO:0005737; GO:0005769; GO:0005884; GO:0005886; GO:0005903; GO:0006892; GO:0007015; GO:0010008; GO:0016459; GO:0030048; GO:0030175; GO:0048471; GO:0051015; GO:0051017; GO:0070062; GO:0071944 0 0 0 PF00612;PF00063;PF06017; P46825 CHOYP_KLC.2.3 m.40314 sp KLC_DORPE 84.557 531 72 4 27 554 4 527 0 899 KLC_DORPE reviewed Kinesin light chain (KLC) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 571 0 GO:0003777; GO:0005737; GO:0005871; GO:0005874 0 0 0 PF13374; P46935 CHOYP_NEDD4L.1.1 m.56591 sp NEDD4_MOUSE 51.806 886 318 18 20 871 77 887 0 835 NEDD4_MOUSE reviewed E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) Nedd4 Kiaa0093 Nedd-4 Nedd4-1 Nedd4a Mus musculus (Mouse) 887 adaptive immune response [GO:0002250]; blood vessel morphogenesis [GO:0048514]; development involved in symbiotic interaction [GO:0044111]; endocardial cushion development [GO:0003197]; glucocorticoid receptor signaling pathway [GO:0042921]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [GO:0010768]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; outflow tract morphogenesis [GO:0003151]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; T cell activation [GO:0042110]; transmission of virus [GO:0019089]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] GO:0000122; GO:0000151; GO:0000785; GO:0002250; GO:0003151; GO:0003197; GO:0005634; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0005938; GO:0006513; GO:0006622; GO:0007528; GO:0010766; GO:0010768; GO:0014068; GO:0014894; GO:0016020; GO:0016567; GO:0016874; GO:0019089; GO:0019871; GO:0030948; GO:0031175; GO:0031623; GO:0032801; GO:0035255; GO:0042110; GO:0042391; GO:0042787; GO:0042921; GO:0043162; GO:0044111; GO:0045121; GO:0045732; GO:0046824; GO:0048471; GO:0048514; GO:0048814; GO:0050807; GO:0050815; GO:0050816; GO:0050847; GO:0061630; GO:0070062; GO:0070064; GO:0070534; GO:1901016; GO:2000650 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00168;PF00632;PF00397; P46940 CHOYP_IQGA1.1.1 m.47731 sp IQGA1_HUMAN 52.208 1653 758 10 22 1664 26 1656 0 1688 IQGA1_HUMAN reviewed Ras GTPase-activating-like protein IQGAP1 (p195) IQGAP1 KIAA0051 Homo sapiens (Human) 1657 cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glomerular visceral epithelial cell development [GO:0072015]; negative regulation of dephosphorylation [GO:0035305]; neuron projection extension [GO:1990138]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein kinase activity [GO:0045860]; regulation of cytokine production [GO:0001817]; signal transduction [GO:0007165] GO:0001726; GO:0001817; GO:0005095; GO:0005096; GO:0005509; GO:0005516; GO:0005547; GO:0005737; GO:0005829; GO:0005874; GO:0005884; GO:0005886; GO:0005913; GO:0005925; GO:0007165; GO:0007173; GO:0008543; GO:0016328; GO:0019901; GO:0019903; GO:0019904; GO:0030424; GO:0030426; GO:0030496; GO:0031234; GO:0035305; GO:0036057; GO:0036120; GO:0036464; GO:0043005; GO:0043234; GO:0043539; GO:0044548; GO:0045860; GO:0048008; GO:0070062; GO:0071277; GO:0071364; GO:0072015; GO:0098641; GO:1990138 0 0 0 PF00307;PF00612;PF00616;PF03836; P47791 CHOYP_LOC100561262.1.1 m.16846 sp GSHR_MOUSE 62.931 464 157 4 13 462 38 500 0 581 GSHR_MOUSE reviewed "Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)" Gsr Gr1 Mus musculus (Mouse) 500 cell redox homeostasis [GO:0045454]; glutathione metabolic process [GO:0006749] GO:0004362; GO:0005739; GO:0006749; GO:0009897; GO:0045454; GO:0050660; GO:0050661; GO:0070062 0 0 0 PF07992;PF02852; P47812 CHOYP_LOC100881316.1.1 m.51540 sp MK14_XENLA 69.942 346 104 0 21 366 6 351 0 525 MK14_XENLA reviewed Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Mitogen-activated Mitogen-activated protein kinase 2) (MAP kinase 2) (MPK2) mapk14 mpk2 Xenopus laevis (African clawed frog) 361 "intracellular signal transduction [GO:0035556]; p38MAPK cascade [GO:0038066]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0004707; GO:0005524; GO:0005622; GO:0006351; GO:0006357; GO:0010831; GO:0035556; GO:0038066; GO:0045663; GO:1901741 0 0 0 PF00069; P47856 CHOYP_PHUM_PHUM536560.2.2 m.59367 sp GFPT1_MOUSE 68.831 693 208 3 1 687 1 691 0 986 GFPT1_MOUSE reviewed Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) Gfpt1 Gfpt Mus musculus (Mouse) 697 carbohydrate metabolic process [GO:0005975]; cellular response to insulin stimulus [GO:0032869]; circadian regulation of gene expression [GO:0032922]; fructose 6-phosphate metabolic process [GO:0006002]; glucosamine biosynthetic process [GO:0006042]; glutamine metabolic process [GO:0006541]; negative regulation of glycogen biosynthetic process [GO:0045719]; protein homotetramerization [GO:0051289]; response to sucrose [GO:0009744]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] GO:0004360; GO:0005975; GO:0006002; GO:0006042; GO:0006047; GO:0006048; GO:0006541; GO:0009744; GO:0016597; GO:0030246; GO:0032869; GO:0032922; GO:0045719; GO:0051289; GO:0070062 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000250|UniProtKB:P82808}. 0 0 PF01380; P47897 CHOYP_QARS.2.2 m.18038 sp SYQ_HUMAN 64.02 781 270 4 2 780 3 774 0 1055 SYQ_HUMAN reviewed Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) QARS Homo sapiens (Human) 775 brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425]; tRNA aminoacylation for protein translation [GO:0006418] GO:0003723; GO:0004819; GO:0005524; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006418; GO:0006425; GO:0007420 0 0 0 PF00749;PF03950;PF04558;PF04557; P47989 CHOYP_LOC100181350.1.1 m.2782 sp XDH_HUMAN 41.071 1344 726 20 21 1316 6 1331 0 969 XDH_HUMAN reviewed Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH XDHA Homo sapiens (Human) 1333 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; lactation [GO:0007595]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; negative regulation of vasculogenesis [GO:2001213]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; purine nucleotide catabolic process [GO:0006195]; xanthine catabolic process [GO:0009115] GO:0001933; GO:0001937; GO:0004854; GO:0004855; GO:0005506; GO:0005615; GO:0005777; GO:0005829; GO:0006195; GO:0006919; GO:0007595; GO:0009055; GO:0009115; GO:0010629; GO:0016529; GO:0016614; GO:0016903; GO:0042803; GO:0043546; GO:0045602; GO:0050660; GO:0051537; GO:0051898; GO:1900745; GO:1900747; GO:2000379; GO:2001213 0 0 0 PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; P47989 CHOYP_XDH.3.3 m.55146 sp XDH_HUMAN 39.697 1320 724 20 29 1286 1 1310 0 889 XDH_HUMAN reviewed Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH XDHA Homo sapiens (Human) 1333 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; lactation [GO:0007595]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; negative regulation of vasculogenesis [GO:2001213]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; purine nucleotide catabolic process [GO:0006195]; xanthine catabolic process [GO:0009115] GO:0001933; GO:0001937; GO:0004854; GO:0004855; GO:0005506; GO:0005615; GO:0005777; GO:0005829; GO:0006195; GO:0006919; GO:0007595; GO:0009055; GO:0009115; GO:0010629; GO:0016529; GO:0016614; GO:0016903; GO:0042803; GO:0043546; GO:0045602; GO:0050660; GO:0051537; GO:0051898; GO:1900745; GO:1900747; GO:2000379; GO:2001213 0 0 0 PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; P47990 CHOYP_XDH.1.3 m.46824 sp XDH_CHICK 42.236 1333 709 15 21 1299 10 1335 0 1023 XDH_CHICK reviewed Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Gallus gallus (Chicken) 1358 urate biosynthetic process [GO:0034418]; xanthine catabolic process [GO:0009115] GO:0004854; GO:0004855; GO:0005506; GO:0005777; GO:0005829; GO:0009055; GO:0009115; GO:0016614; GO:0016903; GO:0030151; GO:0034418; GO:0043546; GO:0050660; GO:0051537; GO:0070674 0 0 0 PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; P47990 CHOYP_XDH.2.3 m.53113 sp XDH_CHICK 60.178 1351 511 7 5 1330 8 1356 0 1658 XDH_CHICK reviewed Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Gallus gallus (Chicken) 1358 urate biosynthetic process [GO:0034418]; xanthine catabolic process [GO:0009115] GO:0004854; GO:0004855; GO:0005506; GO:0005777; GO:0005829; GO:0009055; GO:0009115; GO:0016614; GO:0016903; GO:0030151; GO:0034418; GO:0043546; GO:0050660; GO:0051537; GO:0070674 0 0 0 PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; P48147 CHOYP_BRAFLDRAFT_204923.1.2 m.1690 sp PPCE_HUMAN 64.255 705 250 2 2 704 4 708 0 979 PPCE_HUMAN reviewed Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP PEP Homo sapiens (Human) 710 proteolysis [GO:0006508] GO:0004252; GO:0005634; GO:0005737; GO:0006508; GO:0008236; GO:0016020; GO:0070008 0 0 0 PF00326;PF02897; P48416 CHOYP_CP10.1.1 m.49682 sp CP10_LYMST 47.187 551 258 7 18 552 11 544 0 529 CP10_LYMST reviewed Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 545 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037 0 0 0 PF00067; P48601 CHOYP_PRS4.1.1 m.45626 sp PRS4_DROME 91.383 441 36 1 34 474 1 439 0 810 PRS4_DROME reviewed 26S protease regulatory subunit 4 (P26s4) Rpt2 P26s4 Pros26.4 CG5289 Drosophila melanogaster (Fruit fly) 439 cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; mitotic spindle assembly [GO:0090307]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0000022; GO:0005524; GO:0005838; GO:0006974; GO:0007052; GO:0008283; GO:0008540; GO:0016887; GO:0017025; GO:0030433; GO:0031595; GO:0031597; GO:0036402; GO:0043161; GO:0045899; GO:0090307 0 0 0 PF00004; P48612 CHOYP_PELO.1.1 m.14458 sp PELO_DROME 71.429 371 106 0 1 371 1 371 0 584 PELO_DROME reviewed Protein pelota (EC 3.1.-.-) pelo CG3959 Drosophila melanogaster (Fruit fly) 395 "compound eye morphogenesis [GO:0001745]; female germ-line stem cell asymmetric division [GO:0048132]; germ-line stem cell population maintenance [GO:0030718]; male meiosis [GO:0007140]; male meiosis I [GO:0007141]; meiotic G2/MI transition [GO:0008315]; meiotic nuclear division [GO:0007126]; meiotic nuclear envelope disassembly [GO:0051078]; meiotic spindle organization [GO:0000212]; mitotic nuclear division [GO:0007067]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; RNA surveillance [GO:0071025]; spermatocyte division [GO:0048137]; spermatogenesis [GO:0007283]" GO:0000212; GO:0001745; GO:0004519; GO:0005634; GO:0005737; GO:0007067; GO:0007126; GO:0007140; GO:0007141; GO:0007283; GO:0008315; GO:0030718; GO:0046872; GO:0048132; GO:0048137; GO:0051078; GO:0070481; GO:0070966; GO:0071025 0 0 0 PF03463;PF03464;PF03465; P48818 CHOYP_LOC100369524.1.1 m.8159 sp ACADV_BOVIN 63.005 619 217 4 21 628 38 655 0 781 ACADV_BOVIN reviewed "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)" ACADVL VLCAD Bos taurus (Bovine) 655 epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of fatty acid oxidation [GO:0046322]; regulation of cholesterol metabolic process [GO:0090181]; temperature homeostasis [GO:0001659]; very long-chain fatty acid catabolic process [GO:0042760] GO:0000062; GO:0001659; GO:0005730; GO:0005739; GO:0005743; GO:0009055; GO:0017099; GO:0030855; GO:0033539; GO:0042645; GO:0042760; GO:0045717; GO:0046322; GO:0050660; GO:0052890; GO:0055088; GO:0090181 PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. 0 0 PF00441;PF02770;PF02771; P49109 CHOYP_FMO5.1.6 m.4057 sp FMO5_CAVPO 46.881 529 276 3 4 530 5 530 0 521 FMO5_CAVPO reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; P49109 CHOYP_FMO5.5.6 m.40441 sp FMO5_CAVPO 57.317 492 202 5 3 491 4 490 0 585 FMO5_CAVPO reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; P49116 CHOYP_LOC100372393.1.1 m.12043 sp NR2C2_HUMAN 49.568 579 251 13 100 663 44 596 0 530 NR2C2_HUMAN reviewed Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) NR2C2 TAK1 TR4 Homo sapiens (Human) 596 "cell differentiation [GO:0030154]; cerebellum development [GO:0021549]; meiotic cell cycle [GO:0051321]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nervous system development [GO:0007399]; p38MAPK cascade [GO:0038066]; positive regulation of behavior [GO:0048520]; positive regulation of embryonic development [GO:0040019]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0003700; GO:0003707; GO:0003713; GO:0004872; GO:0005654; GO:0006355; GO:0006367; GO:0007283; GO:0007399; GO:0008270; GO:0021549; GO:0030154; GO:0038066; GO:0040019; GO:0043565; GO:0045663; GO:0045944; GO:0046982; GO:0048520; GO:0051321; GO:0098779 0 0 0 PF00104;PF00105; P49139 CHOYP_LOC100368658.1.1 m.16577 sp MAPK2_RABIT 69.617 339 103 0 40 378 17 355 0 515 MAPK2_RABIT reviewed MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) (Fragment) MAPKAPK2 Oryctolagus cuniculus (Rabbit) 366 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to DNA damage stimulus [GO:0006974]; G2 DNA damage checkpoint [GO:0031572]; inflammatory response [GO:0006954]; macropinocytosis [GO:0044351]; regulation of interleukin-6 production [GO:0032675]; regulation of tumor necrosis factor production [GO:0032680]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006954; GO:0006974; GO:0031572; GO:0032496; GO:0032675; GO:0032680; GO:0034097; GO:0044351; GO:0070935 0 0 0 PF00069; P49165 CHOYP_RL4.2.6 m.4481 sp RL4_URECA 72.533 375 98 2 1 375 1 370 0 556 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; P49165 CHOYP_RL4.6.6 m.66341 sp RL4_URECA 71.762 386 94 3 32 403 1 385 0 555 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; P49366 CHOYP_DHPS.1.1 m.55870 sp DHYS_HUMAN 69.061 362 112 0 1 362 5 366 0 547 DHYS_HUMAN reviewed Deoxyhypusine synthase (DHS) (EC 2.5.1.46) DHPS DS Homo sapiens (Human) 369 deoxyhypusine biosynthetic process from spermidine [GO:0050983]; glucose homeostasis [GO:0042593]; peptidyl-lysine modification to peptidyl-hypusine [GO:0008612]; positive regulation of cell proliferation [GO:0008284]; positive regulation of T cell proliferation [GO:0042102]; protein homotetramerization [GO:0051289]; translation [GO:0006412] GO:0005737; GO:0005829; GO:0006412; GO:0008284; GO:0008612; GO:0034038; GO:0042102; GO:0042593; GO:0050983; GO:0051289 PATHWAY: Protein modification; eIF5A hypusination. 0 0 PF01916; P49432 CHOYP_KIF2A.2.2 m.62687 sp ODPB_RAT 74.138 348 89 1 12 359 13 359 0 550 ODPB_RAT reviewed "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)" Pdhb Rattus norvegicus (Rat) 359 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099] GO:0004738; GO:0004739; GO:0005739; GO:0005759; GO:0006006; GO:0006086; GO:0006099; GO:0045254 0 0 0 PF02779;PF02780; P49615 CHOYP_CDK5.1.1 m.25495 sp CDK5_MOUSE 83.505 291 48 0 1 291 1 291 0 520 CDK5_MOUSE reviewed Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (CR6 protein kinase) (CRK6) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) Cdk5 Cdkn5 Crk6 Mus musculus (Mouse) 292 "apoptotic process [GO:0006915]; associative learning [GO:0008306]; axonogenesis [GO:0007409]; behavioral response to cocaine [GO:0048148]; blood coagulation [GO:0007596]; calcium ion import [GO:0070509]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; central nervous system neuron development [GO:0021954]; cerebellar cortex development [GO:0021695]; cerebellar cortex formation [GO:0021697]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; cortical actin cytoskeleton organization [GO:0030866]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; forebrain development [GO:0030900]; hippocampus development [GO:0021766]; intracellular protein transport [GO:0006886]; layer formation in cerebral cortex [GO:0021819]; motor neuron axon guidance [GO:0008045]; negative regulation of axon extension [GO:0030517]; negative regulation of cell cycle [GO:0045786]; negative regulation of neuron death [GO:1901215]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of proteolysis [GO:0045861]; negative regulation of synaptic plasticity [GO:0031914]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; nucleocytoplasmic transport [GO:0006913]; oligodendrocyte differentiation [GO:0048709]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein targeting to membrane [GO:0090314]; protein autophosphorylation [GO:0046777]; protein localization to synapse [GO:0035418]; protein phosphorylation [GO:0006468]; receptor catabolic process [GO:0032801]; receptor clustering [GO:0043113]; regulated exocytosis [GO:0045055]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of postsynaptic membrane potential [GO:0060078]; regulation of synaptic plasticity [GO:0048167]; response to cocaine [GO:0042220]; rhythmic process [GO:0048511]; Schwann cell development [GO:0014044]; sensory perception of pain [GO:0019233]; serine phosphorylation of STAT3 protein [GO:0033136]; skeletal muscle tissue development [GO:0007519]; synapse assembly [GO:0007416]; synaptic transmission, dopaminergic [GO:0001963]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle endocytosis [GO:0048488]; telencephalon development [GO:0021537]; visual learning [GO:0008542]" GO:0001764; GO:0001963; GO:0002039; GO:0004672; GO:0004674; GO:0004693; GO:0005176; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006468; GO:0006886; GO:0006913; GO:0006915; GO:0007049; GO:0007160; GO:0007409; GO:0007416; GO:0007519; GO:0007596; GO:0008045; GO:0008306; GO:0008542; GO:0014044; GO:0014069; GO:0016020; GO:0016301; GO:0016310; GO:0016477; GO:0016533; GO:0018105; GO:0018107; GO:0019233; GO:0021537; GO:0021549; GO:0021695; GO:0021697; GO:0021766; GO:0021819; GO:0021954; GO:0021987; GO:0022038; GO:0030027; GO:0030054; GO:0030175; GO:0030182; GO:0030334; GO:0030424; GO:0030425; GO:0030426; GO:0030517; GO:0030549; GO:0030866; GO:0030900; GO:0031175; GO:0031397; GO:0031594; GO:0031914; GO:0032092; GO:0032801; GO:0033136; GO:0035249; GO:0035418; GO:0042220; GO:0043025; GO:0043113; GO:0043125; GO:0043204; GO:0043525; GO:0045055; GO:0045211; GO:0045786; GO:0045860; GO:0045861; GO:0045892; GO:0045956; GO:0046777; GO:0046826; GO:0048148; GO:0048167; GO:0048488; GO:0048511; GO:0048709; GO:0048813; GO:0050321; GO:0051301; GO:0051402; GO:0060078; GO:0060079; GO:0061001; GO:0070509; GO:0090314; GO:1901215 0 0 0 PF00069; P49641 CHOYP_MAN2A1.1.1 m.49575 sp MA2A2_HUMAN 35.728 1016 592 22 162 1148 166 1149 0 672 MA2A2_HUMAN reviewed "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A2 MANA2X Homo sapiens (Human) 1150 mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein deglycosylation [GO:0006517] GO:0000139; GO:0004559; GO:0004572; GO:0006013; GO:0006491; GO:0006517; GO:0008270; GO:0016021; GO:0016799; GO:0030246 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09261;PF01074;PF07748; P49696 CHOYP_BRAFLDRAFT_66627.1.1 m.40620 sp SYVC_TAKRU 63.671 1046 365 6 25 1063 179 1216 0 1355 SYVC_TAKRU reviewed Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) vars vars1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 1217 valyl-tRNA aminoacylation [GO:0006438] GO:0002161; GO:0004832; GO:0005524; GO:0005737; GO:0006438 0 0 cd07962; PF08264;PF00043;PF00133;PF10458; P49746 CHOYP_PHUM_PHUM370970.1.2 m.40102 sp TSP3_HUMAN 57.335 668 273 5 606 1264 277 941 0 728 TSP3_HUMAN reviewed Thrombospondin-3 THBS3 TSP3 Homo sapiens (Human) 956 bone trabecula formation [GO:0060346]; cell-matrix adhesion [GO:0007160]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931] GO:0003417; GO:0005509; GO:0005576; GO:0007160; GO:0008201; GO:0043931; GO:0048471; GO:0060346 0 0 0 PF11598;PF07645;PF02412;PF05735; P49754 CHOYP_LOC100370879.1.1 m.53699 sp VPS41_HUMAN 48.91 826 411 7 23 843 28 847 0 835 VPS41_HUMAN reviewed Vacuolar protein sorting-associated protein 41 homolog (S53) VPS41 Homo sapiens (Human) 854 "autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; Golgi vesicle transport [GO:0048193]; late endosome to lysosome transport [GO:1902774]; protein targeting to vacuole [GO:0006623]; regulated exocytosis [GO:0045055]; regulation of SNARE complex assembly [GO:0035542]; vacuole fusion, non-autophagic [GO:0042144]" GO:0005765; GO:0005769; GO:0005798; GO:0005829; GO:0006623; GO:0006914; GO:0008270; GO:0008333; GO:0010008; GO:0015630; GO:0016020; GO:0030123; GO:0030136; GO:0030897; GO:0031902; GO:0033263; GO:0034058; GO:0035542; GO:0042144; GO:0042802; GO:0045055; GO:0048193; GO:0051020; GO:1902774 0 0 0 PF00637; P49760 CHOYP_CLK2.1.1 m.3081 sp CLK2_HUMAN 72.189 338 93 1 106 442 142 479 0 547 CLK2_HUMAN reviewed Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) CLK2 Homo sapiens (Human) 499 negative regulation of gluconeogenesis [GO:0045721]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]; response to ionizing radiation [GO:0010212]; response to retinoic acid [GO:0032526] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0006468; GO:0010212; GO:0016607; GO:0032526; GO:0043484; GO:0045721; GO:0046777 0 0 0 PF00069; P49760 CHOYP_DOA.1.2 m.26230 sp CLK2_HUMAN 72.727 341 92 1 154 494 142 481 0 543 CLK2_HUMAN reviewed Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) CLK2 Homo sapiens (Human) 499 negative regulation of gluconeogenesis [GO:0045721]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]; response to ionizing radiation [GO:0010212]; response to retinoic acid [GO:0032526] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0006468; GO:0010212; GO:0016607; GO:0032526; GO:0043484; GO:0045721; GO:0046777 0 0 0 PF00069; P49760 CHOYP_DOA.2.2 m.35459 sp CLK2_HUMAN 72.727 341 92 1 76 416 142 481 0 543 CLK2_HUMAN reviewed Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2) CLK2 Homo sapiens (Human) 499 negative regulation of gluconeogenesis [GO:0045721]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of RNA splicing [GO:0043484]; response to ionizing radiation [GO:0010212]; response to retinoic acid [GO:0032526] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0006468; GO:0010212; GO:0016607; GO:0032526; GO:0043484; GO:0045721; GO:0046777 0 0 0 PF00069; P49793 CHOYP_NUP98.1.1 m.8689 sp NUP98_RAT 39.632 1900 852 72 34 1757 29 1809 0 1064 NUP98_RAT reviewed Nuclear pore complex protein Nup98-Nup96 [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)] Nup98 Rattus norvegicus (Rat) 1816 "DNA replication [GO:0006260]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus, docking [GO:0000059]; RNA export from nucleus [GO:0006405]; telomere tethering at nuclear periphery [GO:0034398]" GO:0000059; GO:0000776; GO:0000973; GO:0003723; GO:0005487; GO:0005643; GO:0005654; GO:0006260; GO:0006405; GO:0008139; GO:0017056; GO:0031080; GO:0031965; GO:0034398; GO:0034399; GO:0042277; GO:0042405; GO:0044614; GO:0044615; GO:0051028; GO:0051292 0 0 0 PF04096;PF12110; P49816 CHOYP_LOC101078033.1.1 m.42470 sp TSC2_RAT 39.401 1269 657 25 2 1218 6 1214 0 846 TSC2_RAT reviewed Tuberin (Tuberous sclerosis 2 protein homolog) Tsc2 Rattus norvegicus (Rat) 1809 cell projection organization [GO:0030030]; establishment of protein localization [GO:0045184]; negative regulation of cell size [GO:0045792]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of Wnt signaling pathway [GO:0030178]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; regulation of cell cycle [GO:0051726]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0005856; GO:0005901; GO:0007165; GO:0019902; GO:0030030; GO:0030178; GO:0030425; GO:0030426; GO:0032007; GO:0033596; GO:0043005; GO:0043025; GO:0043231; GO:0043234; GO:0043407; GO:0045121; GO:0045184; GO:0045792; GO:0046627; GO:0046982; GO:0048471; GO:0050680; GO:0051056; GO:0051260; GO:0051291; GO:0051726; GO:0051898 0 0 0 PF11864;PF02145;PF03542; P49916 CHOYP_BRAFLDRAFT_119901.1.1 m.7089 sp DNLI3_HUMAN 53.2 953 381 12 57 978 88 1006 0 981 DNLI3_HUMAN reviewed DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) 1009 "base-excision repair, DNA ligation [GO:0006288]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]; nucleotide-excision repair, DNA gap filling [GO:0006297]; transcription-coupled nucleotide-excision repair [GO:0006283]" GO:0000724; GO:0003677; GO:0003909; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0006260; GO:0006266; GO:0006283; GO:0006288; GO:0006297; GO:0006302; GO:0007005; GO:0007049; GO:0008270; GO:0043504; GO:0051301; GO:0070421; GO:0071897; GO:0090298; GO:0097681 0 0 0 PF04679;PF01068;PF04675;PF16759;PF00645; P49951 CHOYP_CLH1.2.2 m.22327 sp CLH1_BOVIN 83.988 1680 262 2 872 2550 2 1675 0 2981 CLH1_BOVIN reviewed Clathrin heavy chain 1 CLTC Bos taurus (Bovine) 1675 intracellular protein transport [GO:0006886]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; vesicle-mediated transport [GO:0016192] GO:0005198; GO:0005739; GO:0006886; GO:0016192; GO:0030117; GO:0030130; GO:0030132; GO:0042470; GO:1900126 0 0 0 PF00637;PF09268;PF01394; P49959 CHOYP_MRE11.1.2 m.1368 sp MRE11_HUMAN 54.78 659 270 11 129 766 10 661 0 694 MRE11_HUMAN reviewed Double-strand break repair protein MRE11A (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) MRE11A HNGS1 MRE11 Homo sapiens (Human) 708 cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; heart development [GO:0007507]; intra-S DNA damage checkpoint [GO:0031573]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of type I interferon production [GO:0032481]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; regulation of signal transduction by p53 class mediator [GO:1901796]; sister chromatid cohesion [GO:0007062]; strand displacement [GO:0000732]; synapsis [GO:0007129]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860]; viral process [GO:0016032] GO:0000014; GO:0000019; GO:0000724; GO:0000729; GO:0000731; GO:0000732; GO:0000784; GO:0000790; GO:0000794; GO:0003690; GO:0004518; GO:0004520; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005913; GO:0006260; GO:0006281; GO:0006302; GO:0006303; GO:0006310; GO:0006974; GO:0007004; GO:0007062; GO:0007095; GO:0007129; GO:0007131; GO:0007507; GO:0008022; GO:0008283; GO:0008408; GO:0016032; GO:0016605; GO:0030145; GO:0030870; GO:0031573; GO:0031860; GO:0031954; GO:0032206; GO:0032481; GO:0032508; GO:0032876; GO:0033674; GO:0035861; GO:0043066; GO:0046597; GO:0048471; GO:0098641; GO:1901796 0 0 0 PF00149;PF04152; P49959 CHOYP_MRE11.2.2 m.33902 sp MRE11_HUMAN 54.78 659 270 11 424 1061 10 661 0 694 MRE11_HUMAN reviewed Double-strand break repair protein MRE11A (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) MRE11A HNGS1 MRE11 Homo sapiens (Human) 708 cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; heart development [GO:0007507]; intra-S DNA damage checkpoint [GO:0031573]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of type I interferon production [GO:0032481]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; regulation of signal transduction by p53 class mediator [GO:1901796]; sister chromatid cohesion [GO:0007062]; strand displacement [GO:0000732]; synapsis [GO:0007129]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860]; viral process [GO:0016032] GO:0000014; GO:0000019; GO:0000724; GO:0000729; GO:0000731; GO:0000732; GO:0000784; GO:0000790; GO:0000794; GO:0003690; GO:0004518; GO:0004520; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005913; GO:0006260; GO:0006281; GO:0006302; GO:0006303; GO:0006310; GO:0006974; GO:0007004; GO:0007062; GO:0007095; GO:0007129; GO:0007131; GO:0007507; GO:0008022; GO:0008283; GO:0008408; GO:0016032; GO:0016605; GO:0030145; GO:0030870; GO:0031573; GO:0031860; GO:0031954; GO:0032206; GO:0032481; GO:0032508; GO:0032876; GO:0033674; GO:0035861; GO:0043066; GO:0046597; GO:0048471; GO:0098641; GO:1901796 0 0 0 PF00149;PF04152; P50123 CHOYP_ENPEP.1.1 m.12765 sp AMPE_RAT 40.105 955 529 21 19 962 19 941 0 713 AMPE_RAT reviewed Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (CD antigen CD249) Enpep Rattus norvegicus (Rat) 945 angiotensin maturation [GO:0002003]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cellular aromatic compound metabolic process [GO:0006725]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081] GO:0002003; GO:0003081; GO:0004177; GO:0005737; GO:0005886; GO:0006508; GO:0006725; GO:0008217; GO:0008270; GO:0008283; GO:0012506; GO:0016021; GO:0016477; GO:0031983; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P50395 CHOYP_LOC100168945.1.1 m.37004 sp GDIB_HUMAN 65.057 435 151 1 1 434 1 435 0 611 GDIB_HUMAN reviewed Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) GDI2 RABGDIB Homo sapiens (Human) 445 protein transport [GO:0015031]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005093; GO:0005096; GO:0005737; GO:0005794; GO:0005829; GO:0005925; GO:0007165; GO:0007264; GO:0015031; GO:0016020; GO:0016192; GO:0016491; GO:0031982; GO:0043209; GO:0044822; GO:0051056; GO:0070062 0 0 0 PF00996; P50416 CHOYP_LOC100647521.2.2 m.59908 sp CPT1A_HUMAN 57.516 765 323 2 1 763 1 765 0 926 CPT1A_HUMAN reviewed "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" CPT1A CPT1 Homo sapiens (Human) 773 carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; circadian rhythm [GO:0007623]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; glucose metabolic process [GO:0006006]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; protein homooligomerization [GO:0051260]; regulation of insulin secretion [GO:0050796]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; triglyceride metabolic process [GO:0006641] GO:0001676; GO:0004095; GO:0005739; GO:0005741; GO:0005743; GO:0006006; GO:0006635; GO:0006641; GO:0006853; GO:0007623; GO:0009437; GO:0014070; GO:0016020; GO:0030855; GO:0031307; GO:0032000; GO:0042493; GO:0042755; GO:0050796; GO:0051260; GO:0071398; GO:1990698 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00755;PF16484; P50416 CHOYP_LOC577934.1.1 m.6567 sp CPT1A_HUMAN 40.342 761 426 11 19 770 25 766 0 566 CPT1A_HUMAN reviewed "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" CPT1A CPT1 Homo sapiens (Human) 773 carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; circadian rhythm [GO:0007623]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; glucose metabolic process [GO:0006006]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; protein homooligomerization [GO:0051260]; regulation of insulin secretion [GO:0050796]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; triglyceride metabolic process [GO:0006641] GO:0001676; GO:0004095; GO:0005739; GO:0005741; GO:0005743; GO:0006006; GO:0006635; GO:0006641; GO:0006853; GO:0007623; GO:0009437; GO:0014070; GO:0016020; GO:0030855; GO:0031307; GO:0032000; GO:0042493; GO:0042755; GO:0050796; GO:0051260; GO:0071398; GO:1990698 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00755;PF16484; P50430 CHOYP_LOC100377677.2.2 m.27049 sp ARSB_RAT 53.673 490 202 7 25 491 40 527 0 545 ARSB_RAT reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb Rattus norvegicus (Rat) 528 autophagy [GO:0006914]; central nervous system development [GO:0007417]; colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005791; GO:0005794; GO:0006914; GO:0007417; GO:0007584; GO:0008152; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0043627; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; P50532 CHOYP_NEMVEDRAFT_V1G106520.1.1 m.14881 sp SMC4_XENLA 56.705 1208 516 5 39 1243 70 1273 0 1306 SMC4_XENLA reviewed Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome assembly protein XCAP-C) (Chromosome-associated protein C) smc4 capc smc4l1 Xenopus laevis (African clawed frog) 1290 cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] GO:0005524; GO:0005634; GO:0005694; GO:0005829; GO:0007076; GO:0046982; GO:0051301 0 0 0 PF06470;PF02463; P50533 CHOYP_SMC2.1.4 m.17836 sp SMC2_XENLA 62.883 1207 440 3 1 1206 1 1200 0 1527 SMC2_XENLA reviewed Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome assembly protein XCAP-E) (Chromosome-associated protein E) smc2 cape smc2l1 Xenopus laevis (African clawed frog) 1203 cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] GO:0000796; GO:0005524; GO:0005634; GO:0005829; GO:0007076; GO:0051301 0 0 0 PF06470;PF02463; P50748 CHOYP_KNTC1.1.1 m.17136 sp KNTC1_HUMAN 28.822 2165 1359 48 1 2058 97 2186 0 749 KNTC1_HUMAN reviewed Kinetochore-associated protein 1 (Rough deal homolog) (HsROD) (Rod) (hRod) KNTC1 KIAA0166 Homo sapiens (Human) 2209 cell division [GO:0051301]; mitotic cell cycle checkpoint [GO:0007093]; mitotic nuclear division [GO:0007067]; protein complex assembly [GO:0006461]; regulation of exit from mitosis [GO:0007096]; sister chromatid cohesion [GO:0007062] GO:0000777; GO:0000922; GO:0005634; GO:0005737; GO:0005828; GO:0005829; GO:0005886; GO:0006461; GO:0007062; GO:0007067; GO:0007093; GO:0007096; GO:0015629; GO:0051301; GO:1990423 0 0 0 PF10493; P51174 CHOYP_ACADL.1.1 m.5508 sp ACADL_MOUSE 75.879 398 96 0 55 452 32 429 0 671 ACADL_MOUSE reviewed "Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8)" Acadl Mus musculus (Mouse) 430 "carnitine catabolic process [GO:0042413]; carnitine metabolic process, CoA-linked [GO:0019254]; cellular lipid catabolic process [GO:0044242]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty acid catabolic process [GO:0009062]; lipid homeostasis [GO:0055088]; long-chain fatty acid catabolic process [GO:0042758]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of fatty acid oxidation [GO:0046322]; oxidation-reduction process [GO:0055114]; regulation of cholesterol metabolic process [GO:0090181]; response to cold [GO:0009409]; temperature homeostasis [GO:0001659]" GO:0000062; GO:0001659; GO:0004466; GO:0005739; GO:0005759; GO:0009055; GO:0009062; GO:0009409; GO:0016401; GO:0019254; GO:0033539; GO:0042413; GO:0042758; GO:0044242; GO:0045717; GO:0046322; GO:0050660; GO:0052890; GO:0055088; GO:0055114; GO:0090181 PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. 0 0 PF00441;PF02770;PF02771; P51464 CHOYP_BRAFLDRAFT_287716.1.1 m.51443 sp ARLY_LITCT 62.609 460 172 0 2 461 4 463 0 617 ARLY_LITCT reviewed Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) ASL Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 467 arginine biosynthetic process via ornithine [GO:0042450]; urea cycle [GO:0000050] GO:0000050; GO:0004056; GO:0042450 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.; PATHWAY: Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1. 0 cd01359; PF14698;PF00206; P51554 CHOYP_TRIADDRAFT_31868.1.1 m.23117 sp EF1A_HYDVU 83.843 458 73 1 21 477 4 461 0 791 EF1A_HYDVU reviewed Elongation factor 1-alpha (EF-1-alpha) 0 Hydra vulgaris (Hydra) (Hydra attenuata) 468 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; P51610 CHOYP_BRAFLDRAFT_122422.1.2 m.52874 sp HCFC1_HUMAN 80 385 77 0 7 391 18 402 0 727 HCFC1_HUMAN reviewed Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] HCFC1 HCF1 HFC1 Homo sapiens (Human) 2035 "cell cycle [GO:0007049]; cellular response to organic cyclic compound [GO:0071407]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; mitochondrion organization [GO:0007005]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cell cycle [GO:0045787]; positive regulation of gene expression [GO:0010628]; protein stabilization [GO:0050821]; regulation of protein complex assembly [GO:0043254]; regulation of transcription, DNA-templated [GO:0006355]; release from viral latency [GO:0019046]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0000123; GO:0001205; GO:0003682; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005913; GO:0006355; GO:0006366; GO:0007005; GO:0007049; GO:0010628; GO:0016020; GO:0019046; GO:0030424; GO:0030425; GO:0042802; GO:0043025; GO:0043254; GO:0043981; GO:0043982; GO:0043984; GO:0045787; GO:0048188; GO:0050821; GO:0070688; GO:0071339; GO:0071407; GO:0098641 0 0 0 PF01344; P51650 CHOYP_LOC584281.1.1 m.34958 sp SSDH_RAT 62.947 475 172 2 82 554 51 523 0 608 SSDH_RAT reviewed "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" Aldh5a1 Ssadh Rattus norvegicus (Rat) 523 central nervous system development [GO:0007417]; gamma-aminobutyric acid catabolic process [GO:0009450]; oxidation-reduction process [GO:0055114]; succinate metabolic process [GO:0006105] GO:0004029; GO:0004777; GO:0005739; GO:0006105; GO:0007417; GO:0009013; GO:0009450; GO:0031406; GO:0051287; GO:0055114 PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation. 0 0 PF00171; P51659 CHOYP_DHB4.1.2 m.13985 sp DHB4_HUMAN 60.569 738 270 8 14 737 1 731 0 912 DHB4_HUMAN reviewed "Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MPF-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]" HSD17B4 EDH17B4 SDR8C1 Homo sapiens (Human) 736 alpha-linolenic acid metabolic process [GO:0036109]; androgen metabolic process [GO:0008209]; bile acid biosynthetic process [GO:0006699]; estrogen metabolic process [GO:0008210]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; medium-chain fatty-acyl-CoA metabolic process [GO:0036112]; osteoblast differentiation [GO:0001649]; Sertoli cell development [GO:0060009]; very long-chain fatty acid metabolic process [GO:0000038]; very long-chain fatty-acyl-CoA metabolic process [GO:0036111] GO:0000038; GO:0001649; GO:0003857; GO:0005102; GO:0005739; GO:0005777; GO:0005778; GO:0005782; GO:0006635; GO:0006699; GO:0008209; GO:0008210; GO:0016020; GO:0016508; GO:0016853; GO:0033540; GO:0033989; GO:0036109; GO:0036111; GO:0036112; GO:0042803; GO:0043231; GO:0044594; GO:0060009 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00106;PF01575;PF02036; P51688 CHOYP_LOC100378056.1.1 m.65757 sp SPHM_HUMAN 61.078 501 186 4 17 516 10 502 0 641 SPHM_HUMAN reviewed N-sulphoglucosamine sulphohydrolase (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase) SGSH HSS Homo sapiens (Human) 502 glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200] GO:0005764; GO:0006027; GO:0008484; GO:0016250; GO:0030200; GO:0043202; GO:0046872; GO:0070062 0 0 0 PF16347;PF00884; P51791 CHOYP_CLCN3.1.1 m.21245 sp CLCN3_MOUSE 64.241 797 264 6 46 840 41 818 0 1044 CLCN3_MOUSE reviewed H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3) Clcn3 Clc3 Mus musculus (Mouse) 818 "adult locomotory behavior [GO:0008344]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; negative regulation of cell volume [GO:0045794]; neuron cellular homeostasis [GO:0070050]; phagocytosis, engulfment [GO:0006911]; photoreceptor cell maintenance [GO:0045494]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; synaptic transmission, GABAergic [GO:0051932]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle lumen acidification [GO:0097401]" GO:0005247; GO:0005254; GO:0005524; GO:0005768; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0006911; GO:0008021; GO:0008344; GO:0009897; GO:0012506; GO:0015297; GO:0016020; GO:0016021; GO:0030141; GO:0030165; GO:0030658; GO:0031410; GO:0031901; GO:0031902; GO:0034220; GO:0035249; GO:0042581; GO:0043679; GO:0045335; GO:0045494; GO:0045794; GO:0046982; GO:0051932; GO:0060077; GO:0070050; GO:0097401; GO:1902476; GO:1903428 0 0 0 PF00571;PF00654; P51812 CHOYP_KS6A1.1.1 m.38386 sp KS6A3_HUMAN 71.795 741 195 5 1 730 1 738 0 1105 KS6A3_HUMAN reviewed Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) RPS6KA3 ISPK1 MAPKAPK1B RSK2 Homo sapiens (Human) 740 cell cycle [GO:0007049]; central nervous system development [GO:0007417]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of translation in response to stress [GO:0043555]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; toll-like receptor signaling pathway [GO:0002224] GO:0000287; GO:0001501; GO:0002224; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007049; GO:0007165; GO:0007417; GO:0016301; GO:0030307; GO:0032496; GO:0035556; GO:0043027; GO:0043066; GO:0043154; GO:0043555; GO:0043620; GO:0045597; GO:0045944 0 0 0 PF00069;PF00433; P51892 CHOYP_DNLI1.1.2 m.19123 sp DNLI1_XENLA 58.966 909 288 13 105 940 174 1070 0 1068 DNLI1_XENLA reviewed DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) lig1 Xenopus laevis (African clawed frog) 1070 cell cycle [GO:0007049]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation involved in DNA repair [GO:0051103]; DNA recombination [GO:0006310]; DNA replication [GO:0006260] GO:0003677; GO:0003910; GO:0005524; GO:0005634; GO:0006260; GO:0006310; GO:0007049; GO:0046872; GO:0051103; GO:0051301; GO:0071897 0 0 0 PF04679;PF01068;PF04675; P51893 CHOYP_SAHHA.1.1 m.62610 sp SAHHA_XENLA 81.755 433 79 0 52 484 1 433 0 745 SAHHA_XENLA reviewed Adenosylhomocysteinase A (AdoHcyase A) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase A) ahcy-a ahcy ahcy1 Xenopus laevis (African clawed frog) 433 one-carbon metabolic process [GO:0006730] GO:0004013; GO:0006730 PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. 0 cd00401; PF05221;PF00670; P51905 CHOYP_AAEL_AAEL005581.1.1 m.49650 sp SC6A4_DROME 52.993 568 239 5 12 577 67 608 0 615 SC6A4_DROME reviewed Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Cocaine-sensitive serotonin transporter) (dSERT1) SerT CG4545 Drosophila melanogaster (Fruit fly) 622 chemical synaptic transmission [GO:0007268]; monoamine transport [GO:0015844]; phagocytosis [GO:0006909]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610] GO:0005261; GO:0005328; GO:0005886; GO:0005887; GO:0006837; GO:0006909; GO:0007268; GO:0008504; GO:0015222; GO:0015844; GO:0030424; GO:0043679; GO:0046872; GO:0051610; GO:0098793 0 0 0 PF00209; P51905 CHOYP_DERE_GG19936.1.1 m.8894 sp SC6A4_DROME 55.207 605 251 7 91 685 13 607 0 676 SC6A4_DROME reviewed Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Cocaine-sensitive serotonin transporter) (dSERT1) SerT CG4545 Drosophila melanogaster (Fruit fly) 622 chemical synaptic transmission [GO:0007268]; monoamine transport [GO:0015844]; phagocytosis [GO:0006909]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610] GO:0005261; GO:0005328; GO:0005886; GO:0005887; GO:0006837; GO:0006909; GO:0007268; GO:0008504; GO:0015222; GO:0015844; GO:0030424; GO:0043679; GO:0046872; GO:0051610; GO:0098793 0 0 0 PF00209; P51954 CHOYP_NEK1.1.5 m.9137 sp NEK1_MOUSE 35.286 1451 605 50 1 1368 1 1200 0 679 NEK1_MOUSE reviewed Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) Nek1 Mus musculus (Mouse) 1203 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cilium assembly [GO:0042384]; kidney development [GO:0001822]; mitotic nuclear division [GO:0007067]; multicellular organism growth [GO:0035264]; protein phosphorylation [GO:0006468]; regulation of DNA damage checkpoint [GO:2000001]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283] GO:0000242; GO:0001822; GO:0004672; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0006974; GO:0007067; GO:0007283; GO:0010212; GO:0016301; GO:0035264; GO:0042384; GO:0046872; GO:0051301; GO:2000001 0 0 0 PF00069; P51954 CHOYP_NEK1.2.5 m.14211 sp NEK1_MOUSE 34.827 1473 584 52 1 1370 1 1200 0 643 NEK1_MOUSE reviewed Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) Nek1 Mus musculus (Mouse) 1203 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cilium assembly [GO:0042384]; kidney development [GO:0001822]; mitotic nuclear division [GO:0007067]; multicellular organism growth [GO:0035264]; protein phosphorylation [GO:0006468]; regulation of DNA damage checkpoint [GO:2000001]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283] GO:0000242; GO:0001822; GO:0004672; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0006974; GO:0007067; GO:0007283; GO:0010212; GO:0016301; GO:0035264; GO:0042384; GO:0046872; GO:0051301; GO:2000001 0 0 0 PF00069; P51954 CHOYP_NEK1.4.5 m.32116 sp NEK1_MOUSE 35.186 1475 604 50 1 1395 1 1203 0 676 NEK1_MOUSE reviewed Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) Nek1 Mus musculus (Mouse) 1203 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cilium assembly [GO:0042384]; kidney development [GO:0001822]; mitotic nuclear division [GO:0007067]; multicellular organism growth [GO:0035264]; protein phosphorylation [GO:0006468]; regulation of DNA damage checkpoint [GO:2000001]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283] GO:0000242; GO:0001822; GO:0004672; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0006974; GO:0007067; GO:0007283; GO:0010212; GO:0016301; GO:0035264; GO:0042384; GO:0046872; GO:0051301; GO:2000001 0 0 0 PF00069; P51954 CHOYP_NEK1.5.5 m.61355 sp NEK1_MOUSE 34.669 1448 605 49 1 1352 1 1203 0 645 NEK1_MOUSE reviewed Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) Nek1 Mus musculus (Mouse) 1203 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cilium assembly [GO:0042384]; kidney development [GO:0001822]; mitotic nuclear division [GO:0007067]; multicellular organism growth [GO:0035264]; protein phosphorylation [GO:0006468]; regulation of DNA damage checkpoint [GO:2000001]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283] GO:0000242; GO:0001822; GO:0004672; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0006974; GO:0007067; GO:0007283; GO:0010212; GO:0016301; GO:0035264; GO:0042384; GO:0046872; GO:0051301; GO:2000001 0 0 0 PF00069; P51958 CHOYP_contig_056008 m.66602 sp CDK1_CARAU 79.333 300 62 0 1 300 1 300 0 511 CDK1_CARAU reviewed Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) cdk1 cdc2 Carassius auratus (Goldfish) 302 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005815; GO:0007067; GO:0008353; GO:0051301 0 0 0 PF00069; P52034 CHOYP_K6PF.1.1 m.46882 sp PFKA_DROME 63.625 789 276 5 72 860 10 787 0 996 PFKA_DROME reviewed ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) Pfk CG4001 Drosophila melanogaster (Fruit fly) 788 fructose 6-phosphate metabolic process [GO:0006002]; glycolytic process [GO:0006096]; myoblast fusion [GO:0007520]; response to sucrose [GO:0009744]; somatic muscle development [GO:0007525] GO:0003872; GO:0005524; GO:0005945; GO:0006002; GO:0006096; GO:0007520; GO:0007525; GO:0009744; GO:0046872 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_03184}. 0 0 PF00365; P52170 CHOYP_IMA2.2.2 m.49279 sp IMA5_XENLA 59.959 487 192 2 5 489 8 493 0 616 IMA5_XENLA reviewed Importin subunit alpha-5 (Karyopherin subunit alpha-1) kpna1 Xenopus laevis (African clawed frog) 522 protein import into nucleus [GO:0006606] GO:0005634; GO:0005737; GO:0006606; GO:0008565 0 0 0 PF00514;PF16186;PF01749; P52209 CHOYP_NEMVEDRAFT_V1G230495.1.1 m.61211 sp 6PGD_HUMAN 76.495 485 111 2 1 484 1 483 0 761 6PGD_HUMAN reviewed "6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" PGD PGDH Homo sapiens (Human) 483 "D-gluconate metabolic process [GO:0019521]; oxidation-reduction process [GO:0055114]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]" GO:0004616; GO:0005634; GO:0005829; GO:0006098; GO:0009051; GO:0019322; GO:0019521; GO:0055114; GO:0070062 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. 0 0 PF00393;PF03446; P52632 CHOYP_LOC100880948.1.1 m.25232 sp STA5B_RAT 43.182 792 403 19 141 917 1 760 0 592 STA5B_RAT reviewed Signal transducer and activator of transcription 5B Stat5b Rattus norvegicus (Rat) 786 "acute-phase response [GO:0006953]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; JAK-STAT cascade [GO:0007259]; liver development [GO:0001889]; luteinization [GO:0001553]; positive regulation of cellular component movement [GO:0051272]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; prolactin signaling pathway [GO:0038161]; regulation of transcription, DNA-templated [GO:0006355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to peptide hormone [GO:0043434]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0001553; GO:0001666; GO:0001889; GO:0003677; GO:0003682; GO:0003690; GO:0003700; GO:0004871; GO:0005634; GO:0005737; GO:0005829; GO:0006355; GO:0006366; GO:0006953; GO:0007259; GO:0032496; GO:0038161; GO:0043434; GO:0043565; GO:0045471; GO:0045648; GO:0045944; GO:0046983; GO:0048661; GO:0051272; GO:0071363; GO:0071364 0 0 0 PF00017;PF01017;PF02864;PF02865; P52732 CHOYP_KI11A.1.1 m.14576 sp KIF11_HUMAN 40.811 1110 543 30 3 1061 9 1055 0 677 KIF11_HUMAN reviewed Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) KIF11 EG5 KNSL1 TRIP5 Homo sapiens (Human) 1056 "antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; microtubule-based movement [GO:0007018]; mitotic centrosome separation [GO:0007100]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; regulation of mitotic centrosome separation [GO:0046602]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; spindle organization [GO:0007051]" GO:0000922; GO:0003777; GO:0005524; GO:0005737; GO:0005819; GO:0005829; GO:0005871; GO:0005874; GO:0006890; GO:0007018; GO:0007051; GO:0007052; GO:0007059; GO:0007067; GO:0007100; GO:0008574; GO:0016020; GO:0019886; GO:0019901; GO:0032403; GO:0046602; GO:0051301; GO:0090307 0 0 0 PF00225;PF13931; P52735 CHOYP_VAV2.1.3 m.40262 sp VAV2_HUMAN 39.084 939 452 23 4 888 2 874 0 622 VAV2_HUMAN reviewed Guanine nucleotide exchange factor VAV2 (VAV-2) VAV2 Homo sapiens (Human) 878 angiogenesis [GO:0001525]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of blood coagulation [GO:0030193]; regulation of cell size [GO:0008361]; regulation of gene expression [GO:0010468]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005085; GO:0005089; GO:0005829; GO:0005886; GO:0007165; GO:0007264; GO:0008361; GO:0010468; GO:0016477; GO:0030032; GO:0030168; GO:0030193; GO:0035023; GO:0038095; GO:0038096; GO:0043065; GO:0043087; GO:0043552; GO:0046872; GO:0048010; GO:0048013; GO:0051056 0 0 0 PF00130;PF11971;PF00169;PF00621;PF00017;PF07653; P53356 CHOYP_LOC100118048.1.1 m.62637 sp HTK16_HYDVU 41.049 782 413 16 46 805 2 757 0 553 HTK16_HYDVU reviewed Tyrosine-protein kinase HTK16 (EC 2.7.10.2) HTK16 Hydra vulgaris (Hydra) (Hydra attenuata) 757 0 GO:0004715; GO:0005524 0 0 0 PF12796;PF07714;PF00017; P53442 CHOYP_ALF.1.3 m.25601 sp ALF_SCHMA 73.278 363 97 0 1 363 1 363 0 548 ALF_SCHMA reviewed Fructose-bisphosphate aldolase (EC 4.1.2.13) 0 Schistosoma mansoni (Blood fluke) 363 glycolytic process [GO:0006096] GO:0004332; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. 0 0 PF00274; P53447 CHOYP_LOC101487903.1.1 m.11818 sp ALDOB_SPAAU 90.659 364 34 0 26 389 1 364 0 689 ALDOB_SPAAU reviewed Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) aldob Sparus aurata (Gilthead sea bream) 364 glycolytic process [GO:0006096] GO:0004332; GO:0005737; GO:0005815; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. 0 0 PF00274; P53470 CHOYP_ACT1.3.7 m.25836 sp ACT1_SCHMA 77.929 367 81 0 5 371 1 367 0 636 ACT1_SCHMA reviewed Actin-1 0 Schistosoma mansoni (Blood fluke) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P53486 CHOYP_ACTB3.1.1 m.26266 sp ACTB3_TAKRU 97.764 313 7 0 72 384 63 375 0 645 ACTB3_TAKRU reviewed "Actin, cytoplasmic 3 (Beta-actin C) [Cleaved into: Actin, cytoplasmic 3, N-terminally processed]" actbc Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P53505 CHOYP_ACT5.1.3 m.30367 sp ACT5_XENLA 94.302 351 17 1 1 348 1 351 0 690 ACT5_XENLA reviewed "Actin, cytoplasmic type 5" 0 Xenopus laevis (African clawed frog) 376 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; P53505 CHOYP_ACT5.3.3 m.41147 sp ACT5_XENLA 76.524 443 22 3 1 443 1 361 0 672 ACT5_XENLA reviewed "Actin, cytoplasmic type 5" 0 Xenopus laevis (African clawed frog) 376 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; P53505 CHOYP_ACTG.1.1 m.58148 sp ACT5_XENLA 79.679 374 66 2 4 367 3 376 0 627 ACT5_XENLA reviewed "Actin, cytoplasmic type 5" 0 Xenopus laevis (African clawed frog) 376 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; P53569 CHOYP_CEBPZ.1.1 m.12869 sp CEBPZ_MOUSE 43.12 923 477 19 419 1319 130 1026 0 712 CEBPZ_MOUSE reviewed CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) Cebpz Cbf2 Cebpa-rs1 Mus musculus (Mouse) 1052 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0005634; GO:0044822; GO:0045944 0 0 0 PF03914; P53569 CHOYP_ZGC_112104.1.1 m.65394 sp CEBPZ_MOUSE 43.599 828 432 16 15 822 42 854 0 674 CEBPZ_MOUSE reviewed CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CBF) (CCAAT-binding factor) Cebpz Cbf2 Cebpa-rs1 Mus musculus (Mouse) 1052 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0005634; GO:0044822; GO:0045944 0 0 0 PF03914; P53611 CHOYP_PGTB2.1.1 m.2614 sp PGTB2_HUMAN 77.576 330 74 0 1 330 1 330 0 566 PGTB2_HUMAN reviewed Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta) RABGGTB GGTB Homo sapiens (Human) 331 cellular protein modification process [GO:0006464]; protein geranylgeranylation [GO:0018344]; regulation of apoptotic process [GO:0042981]; visual perception [GO:0007601] GO:0004663; GO:0005886; GO:0005968; GO:0006464; GO:0007601; GO:0008270; GO:0017137; GO:0018344; GO:0042981 0 0 cd02894; PF00432; P53667 CHOYP_LOC100748762.1.1 m.40617 sp LIMK1_HUMAN 45 640 316 13 22 651 24 637 0 544 LIMK1_HUMAN reviewed LIM domain kinase 1 (LIMK-1) (EC 2.7.11.1) LIMK1 LIMK Homo sapiens (Human) 647 actin cytoskeleton organization [GO:0030036]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; nervous system development [GO:0007399]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of axon extension [GO:0045773]; positive regulation of stress fiber assembly [GO:0051496]; protein phosphorylation [GO:0006468]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] GO:0004672; GO:0004674; GO:0005524; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0005925; GO:0006468; GO:0007165; GO:0007266; GO:0007399; GO:0008270; GO:0016020; GO:0030036; GO:0031072; GO:0032233; GO:0038096; GO:0043005; GO:0044295; GO:0045773; GO:0048471; GO:0051444; GO:0051496 0 0 0 PF00412;PF00595;PF07714; P53992 CHOYP_SC24C.1.1 m.9387 sp SC24C_HUMAN 52.297 1132 481 15 82 1195 4 1094 0 1068 SC24C_HUMAN reviewed Protein transport protein Sec24C (SEC24-related protein C) SEC24C KIAA0079 Homo sapiens (Human) 1094 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] GO:0000139; GO:0002474; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0008270; GO:0012507; GO:0019886; GO:0030127; GO:0048208; GO:0048471 0 0 0 PF00626;PF08033;PF04815;PF04811;PF04810; P53992 CHOYP_SEC24C.1.1 m.15619 sp SC24C_HUMAN 52.632 1159 474 22 23 1171 1 1094 0 1061 SC24C_HUMAN reviewed Protein transport protein Sec24C (SEC24-related protein C) SEC24C KIAA0079 Homo sapiens (Human) 1094 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886] GO:0000139; GO:0002474; GO:0005789; GO:0005829; GO:0006886; GO:0006888; GO:0008270; GO:0012507; GO:0019886; GO:0030127; GO:0048208; GO:0048471 0 0 0 PF00626;PF08033;PF04815;PF04811;PF04810; P54099 CHOYP_DPOG1.1.1 m.35597 sp DPOG1_MOUSE 46.41 1170 521 15 46 1112 44 1210 0 1022 DPOG1_MOUSE reviewed DNA polymerase subunit gamma-1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) Polg Polg1 Mus musculus (Mouse) 1218 aging [GO:0007568]; mitochondrial DNA replication [GO:0006264] GO:0002020; GO:0003677; GO:0003682; GO:0003887; GO:0004527; GO:0005739; GO:0005743; GO:0005760; GO:0006264; GO:0007568; GO:0008408; GO:0042645; GO:0043234; GO:0070062 0 0 0 PF00476; P54359 CHOYP_SEP11.1.2 m.19430 sp SEPT2_DROME 68.395 405 122 2 80 478 15 419 0 588 SEPT2_DROME reviewed Septin-2 Sep2 CG4173 Drosophila melanogaster (Fruit fly) 419 cellularization [GO:0007349]; growth of a germarium-derived egg chamber [GO:0007295]; imaginal disc development [GO:0007444]; mitotic cytokinesis [GO:0000281]; mitotic nuclear division [GO:0007067]; neurogenesis [GO:0022008]; regulation of cell cycle [GO:0051726]; regulation of glucose metabolic process [GO:0010906] GO:0000281; GO:0003924; GO:0005525; GO:0005819; GO:0005875; GO:0005940; GO:0007067; GO:0007295; GO:0007349; GO:0007444; GO:0010906; GO:0022008; GO:0031105; GO:0042803; GO:0045172; GO:0051726 0 0 cd01850; PF00735; P54359 CHOYP_SEP11.2.2 m.35458 sp SEPT2_DROME 68.395 405 122 2 269 667 15 419 0 587 SEPT2_DROME reviewed Septin-2 Sep2 CG4173 Drosophila melanogaster (Fruit fly) 419 cellularization [GO:0007349]; growth of a germarium-derived egg chamber [GO:0007295]; imaginal disc development [GO:0007444]; mitotic cytokinesis [GO:0000281]; mitotic nuclear division [GO:0007067]; neurogenesis [GO:0022008]; regulation of cell cycle [GO:0051726]; regulation of glucose metabolic process [GO:0010906] GO:0000281; GO:0003924; GO:0005525; GO:0005819; GO:0005875; GO:0005940; GO:0007067; GO:0007295; GO:0007349; GO:0007444; GO:0010906; GO:0022008; GO:0031105; GO:0042803; GO:0045172; GO:0051726 0 0 cd01850; PF00735; P54612 CHOYP_2AAA.1.1 m.13306 sp 2AAA_PIG 81.928 581 105 0 424 1004 6 586 0 989 2AAA_PIG reviewed Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) PPP2R1A Sus scrofa (Pig) 589 "chromosome segregation [GO:0007059]; female meiotic division [GO:0007143]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; meiotic spindle elongation [GO:0051232]; mitotic sister chromatid separation [GO:0051306]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein complex assembly [GO:0006461]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]" GO:0000159; GO:0000775; GO:0003823; GO:0004722; GO:0005829; GO:0006461; GO:0007059; GO:0007143; GO:0008601; GO:0051232; GO:0051306; GO:0051754; GO:0070062; GO:0070262; GO:1903538; GO:2001241 0 0 0 PF02985; P54612 CHOYP_2AAA.1.1 m.13307 sp 2AAA_PIG 80.447 358 70 0 1 358 221 578 0 599 2AAA_PIG reviewed Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) PPP2R1A Sus scrofa (Pig) 589 "chromosome segregation [GO:0007059]; female meiotic division [GO:0007143]; meiotic sister chromatid cohesion, centromeric [GO:0051754]; meiotic spindle elongation [GO:0051232]; mitotic sister chromatid separation [GO:0051306]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein complex assembly [GO:0006461]; regulation of meiotic cell cycle process involved in oocyte maturation [GO:1903538]" GO:0000159; GO:0000775; GO:0003823; GO:0004722; GO:0005829; GO:0006461; GO:0007059; GO:0007143; GO:0008601; GO:0051232; GO:0051306; GO:0051754; GO:0070062; GO:0070262; GO:1903538; GO:2001241 0 0 0 PF02985; P54646 CHOYP_SNF1A.1.1 m.52779 sp AAPK2_HUMAN 63.621 580 175 9 1 572 1 552 0 735 AAPK2_HUMAN reviewed 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) PRKAA2 AMPK AMPK2 Homo sapiens (Human) 552 "carnitine shuttle [GO:0006853]; cell cycle arrest [GO:0007050]; cellular response to drug [GO:0035690]; cellular response to glucose starvation [GO:0042149]; cellular response to nutrient levels [GO:0031669]; cellular response to prostaglandin E stimulus [GO:0071380]; cholesterol biosynthetic process [GO:0006695]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; histone-serine phosphorylation [GO:0035404]; intracellular signal transduction [GO:0035556]; lipid biosynthetic process [GO:0008610]; macroautophagy [GO:0016236]; negative regulation of apoptotic process [GO:0043066]; negative regulation of TOR signaling [GO:0032007]; positive regulation of autophagy [GO:0010508]; positive regulation of glycolytic process [GO:0045821]; positive regulation of macroautophagy [GO:0016239]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of energy homeostasis [GO:2000505]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of macroautophagy [GO:0016241]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; response to muscle activity [GO:0014850]; response to stress [GO:0006950]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0003682; GO:0004672; GO:0004674; GO:0004679; GO:0004712; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006468; GO:0006633; GO:0006695; GO:0006853; GO:0006950; GO:0007050; GO:0007165; GO:0008610; GO:0010508; GO:0014850; GO:0016055; GO:0016236; GO:0016239; GO:0016241; GO:0031588; GO:0031669; GO:0032007; GO:0035174; GO:0035404; GO:0035556; GO:0035690; GO:0042149; GO:0042304; GO:0042593; GO:0042752; GO:0043066; GO:0045821; GO:0046872; GO:0047322; GO:0048511; GO:0050405; GO:0055089; GO:0071380; GO:1901796; GO:2000505 0 0 0 PF16579;PF00069; P54802 CHOYP_NAGLU.2.2 m.60267 sp ANAG_HUMAN 43.777 699 383 9 114 807 43 736 0 628 ANAG_HUMAN reviewed Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) 743 cerebellar Purkinje cell layer development [GO:0021680]; glycosaminoglycan catabolic process [GO:0006027]; inner ear receptor cell development [GO:0060119]; locomotor rhythm [GO:0045475]; lysosome organization [GO:0007040]; middle ear morphogenesis [GO:0042474]; nervous system development [GO:0007399]; retinal rod cell development [GO:0046548] GO:0004561; GO:0005764; GO:0006027; GO:0007040; GO:0007399; GO:0021680; GO:0042474; GO:0043202; GO:0045475; GO:0046548; GO:0060119; GO:0070062 0 0 0 PF05089;PF12972;PF12971; P54814 CHOYP_PRS8.1.1 m.40757 sp PRS8_MANSE 92.519 401 27 1 24 424 5 402 0 760 PRS8_MANSE reviewed 26S protease regulatory subunit 8 (Protein 18-56) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 402 protein catabolic process [GO:0030163] GO:0000502; GO:0005524; GO:0005634; GO:0005737; GO:0016787; GO:0030163 0 0 0 PF00004; P54886 CHOYP_LOC100120123.1.1 m.12979 sp P5CS_HUMAN 58.167 753 301 6 54 794 41 791 0 865 P5CS_HUMAN reviewed Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] ALDH18A1 GSAS P5CS PYCS Homo sapiens (Human) 795 cellular amino acid biosynthetic process [GO:0008652]; citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; proline biosynthetic process [GO:0006561] GO:0004349; GO:0004350; GO:0005524; GO:0005737; GO:0005739; GO:0005743; GO:0006536; GO:0006561; GO:0006592; GO:0008652; GO:0017084; GO:0019240; GO:0042802; GO:0044822; GO:0055129 PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. {ECO:0000269|PubMed:26297558}.; PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. {ECO:0000269|PubMed:26297558}. 0 cd07079; PF00696;PF00171; P54961 CHOYP_LOC100375733.1.1 m.66021 sp HMCS1_BLAGE 65.351 456 151 4 10 463 2 452 0 627 HMCS1_BLAGE reviewed Hydroxymethylglutaryl-CoA synthase 1 (HMG-CoA synthase 1) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase 1) HMGCS-1 Blattella germanica (German cockroach) (Blatta germanica) 453 isoprenoid biosynthetic process [GO:0008299]; sterol biosynthetic process [GO:0016126] GO:0004421; GO:0008299; GO:0016126 PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3. 0 0 PF08540;PF01154; P55013 CHOYP_S12A2.1.2 m.32137 sp S12A2_SQUAC 51.226 1060 453 16 121 1157 173 1191 0 1041 S12A2_SQUAC reviewed Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (NKCC) (Na-K-CL symporter) SLC12A2 NKCC1 Squalus acanthias (Spiny dogfish) 1191 potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] GO:0006813; GO:0006814; GO:0015377; GO:0016021 0 0 0 PF00324;PF08403;PF03522; P55013 CHOYP_S12A2.2.2 m.39394 sp S12A2_SQUAC 47.992 1046 483 15 163 1188 187 1191 0 927 S12A2_SQUAC reviewed Solute carrier family 12 member 2 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1) (NKCC) (Na-K-CL symporter) SLC12A2 NKCC1 Squalus acanthias (Spiny dogfish) 1191 potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] GO:0006813; GO:0006814; GO:0015377; GO:0016021 0 0 0 PF00324;PF08403;PF03522; P55039 CHOYP_DRG2.1.1 m.14009 sp DRG2_HUMAN 79.121 364 76 0 1 364 1 364 0 625 DRG2_HUMAN reviewed Developmentally-regulated GTP-binding protein 2 (DRG-2) DRG2 Homo sapiens (Human) 364 signal transduction [GO:0007165] GO:0005525; GO:0005654; GO:0005737; GO:0005739; GO:0007165; GO:0016020; GO:0043231 0 0 0 PF01926;PF16897;PF02824; P55096 CHOYP_ABCD3.1.1 m.14559 sp ABCD3_MOUSE 70.846 662 186 4 6 663 1 659 0 966 ABCD3_MOUSE reviewed ATP-binding cassette sub-family D member 3 (68 kDa peroxisomal membrane protein) (PMP68) (70 kDa peroxisomal membrane protein) (PMP70) Abcd3 Pmp70 Pxmp1 Mus musculus (Mouse) 659 fatty acid beta-oxidation [GO:0006635]; fatty acid biosynthetic process [GO:0006633]; peroxisomal long-chain fatty acid import [GO:0015910]; peroxisome organization [GO:0007031]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; very long-chain fatty acid catabolic process [GO:0042760] GO:0005324; GO:0005524; GO:0005739; GO:0005743; GO:0005777; GO:0005778; GO:0005782; GO:0006633; GO:0006635; GO:0007031; GO:0014070; GO:0015910; GO:0016020; GO:0016021; GO:0016887; GO:0042493; GO:0042626; GO:0042760; GO:0042803; GO:0043231 0 0 0 PF06472;PF00005; P55196 CHOYP_BRAFLDRAFT_208117.1.3 m.5064 sp AFAD_HUMAN 48.291 1170 490 29 6 1104 8 1133 0 1009 AFAD_HUMAN reviewed Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) MLLT4 AF6 Homo sapiens (Human) 1824 adherens junction organization [GO:0034332]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005913; GO:0007155; GO:0007165; GO:0007267; GO:0008022; GO:0017016; GO:0030054; GO:0034332; GO:0043547; GO:0090557; GO:0098641 0 0 0 PF01843;PF00498;PF00595;PF00788; P55196 CHOYP_BRAFLDRAFT_208117.2.3 m.13949 sp AFAD_HUMAN 48.291 1170 490 29 6 1104 8 1133 0 1013 AFAD_HUMAN reviewed Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) MLLT4 AF6 Homo sapiens (Human) 1824 adherens junction organization [GO:0034332]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005913; GO:0007155; GO:0007165; GO:0007267; GO:0008022; GO:0017016; GO:0030054; GO:0034332; GO:0043547; GO:0090557; GO:0098641 0 0 0 PF01843;PF00498;PF00595;PF00788; P55196 CHOYP_BRAFLDRAFT_208117.3.3 m.56788 sp AFAD_HUMAN 48.412 1165 486 29 9 1102 13 1133 0 1010 AFAD_HUMAN reviewed Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) MLLT4 AF6 Homo sapiens (Human) 1824 adherens junction organization [GO:0034332]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; establishment of endothelial intestinal barrier [GO:0090557]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005913; GO:0007155; GO:0007165; GO:0007267; GO:0008022; GO:0017016; GO:0030054; GO:0034332; GO:0043547; GO:0090557; GO:0098641 0 0 0 PF01843;PF00498;PF00595;PF00788; P55201 CHOYP_LOC100372837.1.2 m.10615 sp BRPF1_HUMAN 50.611 1310 499 29 2 1259 1 1214 0 1152 BRPF1_HUMAN reviewed Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 Homo sapiens (Human) 1214 "histone H3 acetylation [GO:0043966]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0008270; GO:0043966; GO:0045893; GO:0070776; GO:1901796 0 0 0 PF00439;PF10513;PF00855; P55201 CHOYP_LOC100372837.2.2 m.61675 sp BRPF1_HUMAN 50.116 1291 506 27 2 1231 1 1214 0 1143 BRPF1_HUMAN reviewed Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 Homo sapiens (Human) 1214 "histone H3 acetylation [GO:0043966]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0008270; GO:0043966; GO:0045893; GO:0070776; GO:1901796 0 0 0 PF00439;PF10513;PF00855; P55861 CHOYP_MCM2.1.1 m.14569 sp MCM2_XENLA 76.018 884 204 6 6 884 4 884 0 1381 MCM2_XENLA reviewed DNA replication licensing factor mcm2 (EC 3.6.4.12) (BM28-homolog) (Minichromosome maintenance protein 2) (xMCM2) (p112) mcm2 Xenopus laevis (African clawed frog) 886 cell cycle [GO:0007049]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000785; GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0006268; GO:0006270; GO:0007049; GO:0030174; GO:0042555; GO:0046872 0 0 0 PF00493;PF12619;PF14551; P55862 CHOYP_MCM5.1.1 m.48534 sp MCM5A_XENLA 76.255 737 168 4 9 740 1 735 0 1206 MCM5A_XENLA reviewed DNA replication licensing factor mcm5-A (xMCM5-A) (EC 3.6.4.12) (CDC46 homolog A) (xCDC46-A) (CDC46p) (p92) mcm5-a cdc46-a Xenopus laevis (African clawed frog) 735 cell cycle [GO:0007049]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000785; GO:0003678; GO:0003682; GO:0003688; GO:0005524; GO:0005634; GO:0006268; GO:0006270; GO:0007049; GO:0030174; GO:0042555 0 0 0 PF00493;PF14551; P55884 CHOYP_EIF3B.1.1 m.12232 sp EIF3B_HUMAN 63.977 694 235 5 35 725 127 808 0 962 EIF3B_HUMAN reviewed Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116) EIF3B EIF3S9 Homo sapiens (Human) 814 formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] GO:0000166; GO:0001731; GO:0003743; GO:0005654; GO:0005737; GO:0005829; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0032947; GO:0033290; GO:0070062; GO:0071541; GO:0075522; GO:0075525 0 0 0 PF08662;PF00076; P56192 CHOYP_SYMC.1.1 m.18367 sp SYMC_HUMAN 54.759 893 371 8 28 910 30 899 0 998 SYMC_HUMAN reviewed "Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)" MARS Homo sapiens (Human) 900 methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418] GO:0000049; GO:0004825; GO:0005524; GO:0005737; GO:0005829; GO:0006418; GO:0006431; GO:0016020; GO:0070062 0 0 0 PF00043;PF09334;PF00458; P56399 CHOYP_LOC100377783.1.1 m.14549 sp UBP5_MOUSE 55.504 854 316 12 2 795 7 856 0 958 UBP5_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) Usp5 Isot Mus musculus (Mouse) 858 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0008270; GO:0016579; GO:0032436; GO:0043130; GO:0071108 0 0 0 PF00627;PF00443;PF02148; P56518 CHOYP_BRAFLDRAFT_217516.1.1 m.18628 sp HDAC1_STRPU 77.799 518 98 6 36 539 6 520 0 815 HDAC1_STRPU reviewed Histone deacetylase 1 (HD1) (EC 3.5.1.98) HDAC1 Strongylocentrotus purpuratus (Purple sea urchin) 576 "chromatin modification [GO:0016568]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0004407; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008134; GO:0016568; GO:0032041 0 0 0 PF00850; P56524 CHOYP_ISCW_ISCW014481.1.1 m.61217 sp HDAC4_HUMAN 44.028 1013 420 27 99 1005 93 1064 0 732 HDAC4_HUMAN reviewed Histone deacetylase 4 (HD4) (EC 3.5.1.98) HDAC4 KIAA0288 Homo sapiens (Human) 1084 "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to mechanical stimulus [GO:0071260]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to tumor necrosis factor [GO:0071356]; chromatin modification [GO:0016568]; chromatin remodeling [GO:0006338]; histone deacetylation [GO:0016575]; histone H3 deacetylation [GO:0070932]; histone H4 deacetylation [GO:0070933]; inflammatory response [GO:0006954]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glycolytic process [GO:0045820]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; osteoblast development [GO:0002076]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of cell proliferation [GO:0008284]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of gene expression, epigenetic [GO:0040029]; regulation of protein binding [GO:0043393]; regulation of skeletal muscle fiber development [GO:0048742]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; response to drug [GO:0042493]; response to interleukin-1 [GO:0070555]; skeletal system development [GO:0001501]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000122; GO:0001025; GO:0001047; GO:0001501; GO:0002076; GO:0003682; GO:0003714; GO:0004407; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006338; GO:0006351; GO:0006954; GO:0007399; GO:0008134; GO:0008270; GO:0008284; GO:0008285; GO:0010592; GO:0010832; GO:0010882; GO:0014894; GO:0014898; GO:0014911; GO:0016568; GO:0016575; GO:0017053; GO:0030018; GO:0030183; GO:0030955; GO:0031594; GO:0031672; GO:0032041; GO:0033235; GO:0033558; GO:0033613; GO:0034983; GO:0040029; GO:0042113; GO:0042493; GO:0042641; GO:0042826; GO:0043393; GO:0043433; GO:0043525; GO:0045668; GO:0045820; GO:0045892; GO:0045893; GO:0045944; GO:0048661; GO:0048742; GO:0051091; GO:0070491; GO:0070555; GO:0070932; GO:0070933; GO:0071260; GO:0071356; GO:0071374; GO:1903428 0 0 0 PF12203;PF00850; P56558 CHOYP_OGT1.3.3 m.54325 sp OGT1_RAT 77.51 1036 212 6 3 1029 4 1027 0 1670 OGT1_RAT reviewed UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) Ogt Rattus norvegicus (Rat) 1036 apoptotic process [GO:0006915]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to toxic substance [GO:0097237]; circadian regulation of gene expression [GO:0032922]; forebrain development [GO:0030900]; glucosamine metabolic process [GO:0006041]; histone H3-K4 trimethylation [GO:0080182]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; intracellular distribution of mitochondria [GO:0048312]; negative regulation of cell death [GO:0060548]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of protein ubiquitination [GO:0031397]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of cell size [GO:0045793]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K27 methylation [GO:0061087]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of proteolysis [GO:0045862]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein heterotrimerization [GO:0070208]; protein homotrimerization [GO:0070207]; protein O-linked glycosylation [GO:0006493]; regulation of gluconeogenesis involved in cellular glucose homeostasis [GO:0090526]; regulation of glycolytic process [GO:0006110] GO:0000123; GO:0000791; GO:0001933; GO:0001934; GO:0005547; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006041; GO:0006110; GO:0006493; GO:0006915; GO:0008134; GO:0010628; GO:0010801; GO:0016262; GO:0019904; GO:0030900; GO:0031397; GO:0032869; GO:0032922; GO:0033137; GO:0042277; GO:0042588; GO:0043005; GO:0043025; GO:0043981; GO:0043982; GO:0043984; GO:0045793; GO:0045862; GO:0045944; GO:0048015; GO:0048029; GO:0048312; GO:0060548; GO:0061087; GO:0070207; GO:0070208; GO:0071222; GO:0071333; GO:0080182; GO:0090315; GO:0090526; GO:0097237; GO:0097363; GO:1900038; GO:1900182; GO:1903428 PATHWAY: Protein modification; protein glycosylation. 0 0 PF13844;PF00515;PF13414;PF13181; P56701 CHOYP_PSMD2.1.3 m.13362 sp PSMD2_BOVIN 72.041 887 244 2 17 903 25 907 0 1342 PSMD2_BOVIN reviewed 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Tumor necrosis factor type 1 receptor-associated protein 2) PSMD2 TRAP2 Bos taurus (Bovine) 908 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of protein catabolic process [GO:0042176] GO:0005634; GO:0008540; GO:0016020; GO:0022624; GO:0030234; GO:0034515; GO:0042176; GO:0043161; GO:0070062 0 0 0 PF01851; P56721 CHOYP_PHUM_PHUM119360.1.1 m.10530 sp COLL_DROME 67.3 526 115 14 7 507 26 519 0 677 COLL_DROME reviewed Transcription factor collier (Transcription factor knot) kn col CG10197 Drosophila melanogaster (Fruit fly) 575 "anterior head segmentation [GO:0035288]; blastoderm segmentation [GO:0007350]; dendrite morphogenesis [GO:0048813]; determination of muscle attachment site [GO:0016204]; embryonic development via the syncytial blastoderm [GO:0001700]; head segmentation [GO:0035287]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; muscle cell fate specification [GO:0042694]; pattern specification process [GO:0007389]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; posterior head segmentation [GO:0035289]; regulation of dendrite morphogenesis [GO:0048814]; regulation of gene expression [GO:0010468]; regulation of lamellocyte differentiation [GO:0035203]; regulation of transcription, DNA-templated [GO:0006355]; response to symbiont [GO:0009608]; segment polarity determination [GO:0007367]; specification of segmental identity, intercalary segment [GO:0035291]; ventral cord development [GO:0007419]" GO:0001077; GO:0001700; GO:0003677; GO:0005634; GO:0006355; GO:0007350; GO:0007367; GO:0007389; GO:0007419; GO:0007474; GO:0007476; GO:0007526; GO:0009608; GO:0010468; GO:0016204; GO:0035203; GO:0035287; GO:0035288; GO:0035289; GO:0035291; GO:0042694; GO:0045087; GO:0045944; GO:0046427; GO:0046872; GO:0048813; GO:0048814 0 0 0 PF16422;PF16423;PF01833; P56839 CHOYP_PEPM.1.1 m.14235 sp PEPM_MYTED 87.372 293 37 0 34 326 3 295 0 554 PEPM_MYTED reviewed Phosphoenolpyruvate phosphomutase (PEP mutase) (PEP phosphomutase) (Phosphoenolpyruvate mutase) (EC 5.4.2.9) 0 Mytilus edulis (Blue mussel) 295 organic phosphonate biosynthetic process [GO:0032923] GO:0032923; GO:0046872; GO:0050188 PATHWAY: Phosphorus metabolism; phosphonate biosynthesis. 0 0 0 P56941 CHOYP_BRAFLDRAFT_116988.1.3 m.3947 sp NPC1_PIG 51.653 1301 559 24 36 1318 25 1273 0 1280 NPC1_PIG reviewed Niemann-Pick C1 protein NPC1 Sus scrofa (Pig) 1277 bile acid metabolic process [GO:0008206]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lysosomal transport [GO:0007041]; protein glycosylation [GO:0006486] GO:0005319; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005783; GO:0005887; GO:0006486; GO:0007041; GO:0008203; GO:0008206; GO:0015485; GO:0030301; GO:0031902; GO:0042632; GO:0048471 0 0 0 PF16414;PF02460;PF12349; P56941 CHOYP_BRAFLDRAFT_116988.2.3 m.28451 sp NPC1_PIG 49.649 1281 610 17 17 1285 16 1273 0 1249 NPC1_PIG reviewed Niemann-Pick C1 protein NPC1 Sus scrofa (Pig) 1277 bile acid metabolic process [GO:0008206]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lysosomal transport [GO:0007041]; protein glycosylation [GO:0006486] GO:0005319; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005783; GO:0005887; GO:0006486; GO:0007041; GO:0008203; GO:0008206; GO:0015485; GO:0030301; GO:0031902; GO:0042632; GO:0048471 0 0 0 PF16414;PF02460;PF12349; P56941 CHOYP_BRAFLDRAFT_116988.3.3 m.59124 sp NPC1_PIG 51.536 1302 561 24 36 1319 25 1274 0 1275 NPC1_PIG reviewed Niemann-Pick C1 protein NPC1 Sus scrofa (Pig) 1277 bile acid metabolic process [GO:0008206]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lysosomal transport [GO:0007041]; protein glycosylation [GO:0006486] GO:0005319; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005783; GO:0005887; GO:0006486; GO:0007041; GO:0008203; GO:0008206; GO:0015485; GO:0030301; GO:0031902; GO:0042632; GO:0048471 0 0 0 PF16414;PF02460;PF12349; P57080 CHOYP_UBP25.1.1 m.61531 sp UBP25_MOUSE 42.325 1101 533 28 1 1079 1 1021 0 764 UBP25_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) (mUSP25) Usp25 Mus musculus (Mouse) 1055 negative regulation of ERAD pathway [GO:1904293]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000502; GO:0004843; GO:0005634; GO:0005737; GO:0005783; GO:0006511; GO:0016579; GO:0031625; GO:0032183; GO:0051117; GO:0070536; GO:0071108; GO:1904293 0 0 0 PF00443;PF02809; P57772 CHOYP_LOC100375943.1.1 m.9395 sp SELB_HUMAN 54.975 593 218 8 6 554 7 594 0 657 SELB_HUMAN reviewed "Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific)" EEFSEC SELB Homo sapiens (Human) 596 selenocysteine incorporation [GO:0001514]; translation [GO:0006412] GO:0000049; GO:0001514; GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005634; GO:0005739; GO:0006412; GO:0030529; GO:0035368; GO:0043021 0 0 0 0 P58545 CHOYP_BTBD3.1.3 m.3305 sp BTBD3_MOUSE 71.226 424 122 0 72 495 106 529 0 645 BTBD3_MOUSE reviewed BTB/POZ domain-containing protein 3 Btbd3 Mus musculus (Mouse) 530 cerebral cortex development [GO:0021987]; dendrite morphogenesis [GO:0048813] GO:0005634; GO:0005829; GO:0021987; GO:0048813 0 0 0 PF07707;PF00651;PF08005; P58751 CHOYP_RELN.3.4 m.48195 sp RELN_RAT 40.526 3156 1740 51 422 3490 341 3446 0 2404 RELN_RAT reviewed Reelin (EC 3.4.21.-) Reln Rattus norvegicus (Rat) 3462 axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell morphogenesis involved in differentiation [GO:0000904]; cellular response to dexamethasone stimulus [GO:0071549]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; cerebral cortex tangential migration [GO:0021800]; dentate gyrus development [GO:0021542]; glial cell differentiation [GO:0010001]; hypothalamus development [GO:0021854]; locomotory behavior [GO:0007626]; memory [GO:0007613]; midgut development [GO:0007494]; neuron migration [GO:0001764]; orbitofrontal cortex development [GO:0021769]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; response to amino acid [GO:0043200]; response to axon injury [GO:0048678]; response to corticosterone [GO:0051412]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to hormone [GO:0009725]; response to insecticide [GO:0017085]; response to lithium ion [GO:0010226]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to pain [GO:0048265]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; social behavior [GO:0035176]; spinal cord patterning [GO:0021511] GO:0000904; GO:0001764; GO:0004712; GO:0005578; GO:0005615; GO:0005737; GO:0007155; GO:0007411; GO:0007417; GO:0007420; GO:0007494; GO:0007613; GO:0007626; GO:0008236; GO:0009612; GO:0009636; GO:0009725; GO:0010001; GO:0010226; GO:0014070; GO:0017085; GO:0018108; GO:0021511; GO:0021542; GO:0021769; GO:0021800; GO:0021854; GO:0021987; GO:0030424; GO:0030425; GO:0032570; GO:0035176; GO:0042493; GO:0043005; GO:0043025; GO:0043200; GO:0043204; GO:0045471; GO:0045860; GO:0046872; GO:0048265; GO:0048678; GO:0051057; GO:0051412; GO:0051602; GO:0070542; GO:0071549 0 0 cd08544; PF02014; P58854 CHOYP_BRAFLDRAFT_278559.1.1 m.13066 sp GCP3_MOUSE 51.036 917 412 11 8 905 5 903 0 909 GCP3_MOUSE reviewed Gamma-tubulin complex component 3 (GCP-3) Tubgcp3 Gcp3 Mus musculus (Mouse) 905 centrosome duplication [GO:0051298]; cytoplasmic microtubule organization [GO:0031122]; interphase microtubule nucleation by interphase microtubule organizing center [GO:0051415]; meiotic nuclear division [GO:0007126]; mitotic spindle assembly [GO:0090307] GO:0000923; GO:0005200; GO:0005737; GO:0005813; GO:0005814; GO:0005827; GO:0007126; GO:0008275; GO:0016020; GO:0031122; GO:0043015; GO:0051298; GO:0051415; GO:0090307 0 0 0 PF04130; P59015 CHOYP_VPS18.1.1 m.38708 sp VPS18_DANRE 49.897 974 468 9 1 966 1 962 0 994 VPS18_DANRE reviewed Vacuolar protein sorting-associated protein 18 homolog vps18 Danio rerio (Zebrafish) (Brachydanio rerio) 974 apical protein localization [GO:0045176]; bile acid and bile salt transport [GO:0015721]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; endosome to pigment granule transport [GO:0043485]; eye pigmentation [GO:0048069]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; notochord cell vacuolation [GO:0060036]; optokinetic behavior [GO:0007634]; pigment granule maturation [GO:0048757]; regulation of SNARE complex assembly [GO:0035542]; vesicle docking involved in exocytosis [GO:0006904] GO:0005765; GO:0005768; GO:0006886; GO:0006904; GO:0007032; GO:0007040; GO:0007634; GO:0008333; GO:0015721; GO:0030674; GO:0030897; GO:0031902; GO:0035542; GO:0043485; GO:0045176; GO:0046872; GO:0048069; GO:0048757; GO:0060036 0 0 0 PF00637;PF05131; P59114 CHOYP_PCIF1.1.1 m.59693 sp PCIF1_MOUSE 53.077 650 256 7 88 697 27 667 0 685 PCIF1_MOUSE reviewed Phosphorylated CTD-interacting factor 1 Pcif1 Mus musculus (Mouse) 706 negative regulation of phosphatase activity [GO:0010923] GO:0005654; GO:0010923; GO:0015630; GO:0045171 0 0 0 PF12237;PF00397; P59240 CHOYP_BRAFLDRAFT_119906.1.1 m.45319 sp NPHP4_MOUSE 36.846 1471 839 27 10 1440 4 1424 0 918 NPHP4_MOUSE reviewed Nephrocystin-4 (Nephroretinin) Nphp4 Mus musculus (Mouse) 1425 negative regulation of canonical Wnt signaling pathway [GO:0090090]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; retina development in camera-type eye [GO:0060041]; sperm motility [GO:0030317] GO:0005737; GO:0005813; GO:0005911; GO:0005923; GO:0030317; GO:0032391; GO:0035845; GO:0035869; GO:0045494; GO:0060041; GO:0090090; GO:0097470; GO:0097546 0 0 0 0 P60027 CHOYP_BRAFLDRAFT_57175.1.1 m.7616 sp TF2H4_PANTR 60.532 451 176 1 8 458 14 462 0 569 TF2H4_PANTR reviewed General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit) GTF2H4 Pan troglodytes (Chimpanzee) 462 nucleotide-excision repair [GO:0006289]; phosphorylation of RNA polymerase II C-terminal domain [GO:0070816]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000439; GO:0003690; GO:0003700; GO:0004003; GO:0005675; GO:0006289; GO:0006366; GO:0008353; GO:0070816 0 0 0 PF03849; P60670 CHOYP_NPL4.1.1 m.62114 sp NPL4_MOUSE 55.054 643 247 9 4 641 2 607 0 724 NPL4_MOUSE reviewed Nuclear protein localization protein 4 homolog (Protein NPL4) Nploc4 Kiaa1499 Npl4 Mus musculus (Mouse) 608 "ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; Golgi organization [GO:0007030]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0005634; GO:0005783; GO:0005829; GO:0006511; GO:0007030; GO:0008270; GO:0030433; GO:0030970; GO:0031625; GO:0034098; GO:0036501; GO:0042175; GO:0043130 PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. 0 cd08061; PF05021;PF11543;PF05020; P60892 CHOYP_PRPS1.1.1 m.10083 sp PRPS1_RAT 86.792 318 42 0 21 338 1 318 0 569 PRPS1_RAT reviewed Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) Prps1 Rattus norvegicus (Rat) 318 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; AMP biosynthetic process [GO:0006167]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; nucleotide biosynthetic process [GO:0009165]; organ regeneration [GO:0031100]; ribose phosphate metabolic process [GO:0019693]; urate biosynthetic process [GO:0034418] GO:0000287; GO:0002189; GO:0004749; GO:0005524; GO:0006015; GO:0006167; GO:0007399; GO:0009165; GO:0016208; GO:0016301; GO:0019003; GO:0019693; GO:0030246; GO:0031100; GO:0034418; GO:0042803; GO:0043234; GO:0043531; GO:0046101 PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. 0 cd06223; PF14572;PF13793; P61222 CHOYP_ABCE1.1.2 m.7437 sp ABCE1_MOUSE 83.946 598 96 0 14 611 2 599 0 1062 ABCE1_MOUSE reviewed ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) Abce1 Rli Mus musculus (Mouse) 599 ribosomal subunit export from nucleus [GO:0000054]; translational initiation [GO:0006413]; translational termination [GO:0006415] GO:0000054; GO:0005506; GO:0005524; GO:0005737; GO:0005739; GO:0006413; GO:0006415; GO:0016020; GO:0016887; GO:0043024 0 0 0 PF00005;PF00037;PF04068; P61222 CHOYP_ABCE1.2.2 m.42246 sp ABCE1_MOUSE 83.946 598 96 0 14 611 2 599 0 1063 ABCE1_MOUSE reviewed ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) Abce1 Rli Mus musculus (Mouse) 599 ribosomal subunit export from nucleus [GO:0000054]; translational initiation [GO:0006413]; translational termination [GO:0006415] GO:0000054; GO:0005506; GO:0005524; GO:0005737; GO:0005739; GO:0006413; GO:0006415; GO:0016020; GO:0016887; GO:0043024 0 0 0 PF00005;PF00037;PF04068; P61406 CHOYP_EST1A.1.1 m.59161 sp EST1A_MOUSE 42.685 1080 512 29 708 1726 384 1417 0 756 EST1A_MOUSE reviewed Telomerase-binding protein EST1A (EC 3.1.-.-) (EST1-like protein A) (Ever shorter telomeres 1A) (Smg-6 homolog) (Telomerase subunit EST1A) Smg6 Est1a Kiaa0732 Mus musculus (Mouse) 1418 "negative regulation of telomere capping [GO:1904354]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; telomere maintenance [GO:0000723]" GO:0000184; GO:0000333; GO:0000723; GO:0000781; GO:0004521; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0035145; GO:0042162; GO:0043021; GO:0046872; GO:0070034; GO:0070182; GO:1904354 0 0 0 PF10374;PF10373;PF13638; P61460 CHOYP_LOC100121949.1.2 m.25219 sp DEPD5_MOUSE 48.316 683 303 16 11 677 2 650 0 606 DEPD5_MOUSE reviewed DEP domain-containing protein 5 Depdc5 Kiaa0645 Mus musculus (Mouse) 1591 cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TOR signaling [GO:0032007] GO:0005096; GO:0005764; GO:0005765; GO:0005829; GO:0032007; GO:0032403; GO:0034198; GO:0035556; GO:0048471; GO:1904262; GO:1990130 0 0 0 PF00610;PF12257; P61460 CHOYP_LOC100121949.2.2 m.51417 sp DEPD5_MOUSE 48.382 680 301 16 3 666 5 650 0 603 DEPD5_MOUSE reviewed DEP domain-containing protein 5 Depdc5 Kiaa0645 Mus musculus (Mouse) 1591 cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TOR signaling [GO:0032007] GO:0005096; GO:0005764; GO:0005765; GO:0005829; GO:0032007; GO:0032403; GO:0034198; GO:0035556; GO:0048471; GO:1904262; GO:1990130 0 0 0 PF00610;PF12257; P61765 CHOYP_STXB1.1.1 m.56878 sp STXB1_RAT 66.047 592 192 4 1 590 4 588 0 818 STXB1_RAT reviewed Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1) Stxbp1 Unc18a Rattus norvegicus (Rat) 594 "axon target recognition [GO:0007412]; long term synaptic depression [GO:0060292]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein complex assembly [GO:0031333]; negative regulation of SNARE complex assembly [GO:0035544]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter secretion [GO:0007269]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of exocytosis [GO:0045921]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; protein transport [GO:0015031]; regulation of synaptic vesicle priming [GO:0010807]; synaptic vesicle maturation [GO:0016188]; vesicle docking involved in exocytosis [GO:0006904]" GO:0000149; GO:0002576; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006904; GO:0007269; GO:0007274; GO:0007412; GO:0010807; GO:0015031; GO:0016188; GO:0017075; GO:0019901; GO:0019904; GO:0019905; GO:0031091; GO:0031333; GO:0032229; GO:0035544; GO:0042802; GO:0043195; GO:0043209; GO:0043234; GO:0043524; GO:0044822; GO:0045921; GO:0045956; GO:0047485; GO:0050821; GO:0060292; GO:0070062; GO:0070527; GO:0072659 0 0 0 PF00995; P61963 CHOYP_DCAF7.1.1 m.51583 sp DCAF7_MOUSE 92.33 339 26 0 10 348 4 342 0 669 DCAF7_MOUSE reviewed DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog) Dcaf7 Han11 Wdr68 Mus musculus (Mouse) 342 multicellular organism development [GO:0007275]; protein ubiquitination [GO:0016567] GO:0005654; GO:0005737; GO:0007275; GO:0016363; GO:0016567; GO:0043234; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; P62138 CHOYP_PP1A.1.1 m.25950 sp PP1A_RAT 94.539 293 12 2 1 289 37 329 0 571 PP1A_RAT reviewed Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) Ppp1ca Ppp1a Rattus norvegicus (Rat) 330 branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; triglyceride catabolic process [GO:0019433] GO:0000164; GO:0000781; GO:0004721; GO:0004722; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005977; GO:0005979; GO:0005981; GO:0006470; GO:0007049; GO:0008157; GO:0016791; GO:0019433; GO:0030324; GO:0032403; GO:0032922; GO:0042587; GO:0042752; GO:0043005; GO:0043021; GO:0043025; GO:0043153; GO:0043197; GO:0043204; GO:0046872; GO:0048754; GO:0051301; GO:0070062; GO:0070688; GO:0072357; GO:2001241 0 0 0 PF00149;PF16891; P62138 CHOYP_PPP1CC.1.1 m.13937 sp PP1A_RAT 92.705 329 20 2 1 325 1 329 0 630 PP1A_RAT reviewed Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) Ppp1ca Ppp1a Rattus norvegicus (Rat) 330 branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; triglyceride catabolic process [GO:0019433] GO:0000164; GO:0000781; GO:0004721; GO:0004722; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005977; GO:0005979; GO:0005981; GO:0006470; GO:0007049; GO:0008157; GO:0016791; GO:0019433; GO:0030324; GO:0032403; GO:0032922; GO:0042587; GO:0042752; GO:0043005; GO:0043021; GO:0043025; GO:0043153; GO:0043197; GO:0043204; GO:0046872; GO:0048754; GO:0051301; GO:0070062; GO:0070688; GO:0072357; GO:2001241 0 0 0 PF00149;PF16891; P62205 CHOYP_PLK1.1.2 m.26371 sp PLK1_XENTR 67.759 580 175 4 12 590 29 597 0 835 PLK1_XENTR reviewed Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Plx1) (Polo-like kinase 1) (PLK-1) plk1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 598 cell division [GO:0051301]; G2 DNA damage checkpoint [GO:0031572]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168]; protein phosphorylation [GO:0006468] GO:0000776; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0006468; GO:0007067; GO:0030496; GO:0031572; GO:0051301; GO:0071168 0 0 cd13118;cd13117;cd14187; PF00069;PF00659; P62296 CHOYP_LOC101174988.1.1 m.16918 sp ASPM_SAIBB 31.905 2404 1303 46 685 2866 467 2758 0 1020 ASPM_SAIBB reviewed Abnormal spindle-like microcephaly-associated protein homolog ASPM Saimiri boliviensis boliviensis (Bolivian squirrel monkey) 3469 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; spindle organization [GO:0007051] GO:0005634; GO:0005737; GO:0005819; GO:0007051; GO:0007067; GO:0051301 0 0 0 PF15780;PF00307;PF00612; P62334 CHOYP_PSMC6.1.1 m.13888 sp PRS10_MOUSE 88.158 380 45 0 15 394 5 384 0 694 PRS10_MOUSE reviewed 26S protease regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42) Psmc6 Sug2 Mus musculus (Mouse) 389 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899] GO:0000502; GO:0005524; GO:0005634; GO:0008540; GO:0016020; GO:0016234; GO:0017025; GO:0022624; GO:0030433; GO:0031595; GO:0031597; GO:0036402; GO:0045899; GO:0070062; GO:0090261 0 0 0 PF00004; P62716 CHOYP_SELD.1.2 m.8600 sp PP2AB_RAT 93.528 309 20 0 4 312 1 309 0 623 PP2AB_RAT reviewed Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) Ppp2cb Rattus norvegicus (Rat) 309 negative regulation of Ras protein signal transduction [GO:0046580]; protein dephosphorylation [GO:0006470] GO:0000775; GO:0000922; GO:0004721; GO:0004722; GO:0005634; GO:0005737; GO:0006470; GO:0008022; GO:0046580; GO:0046872; GO:0046982 0 0 0 PF00149; P62944 CHOYP_ISCW_ISCW011108.1.1 m.13934 sp AP2B1_RAT 73.024 949 226 6 32 962 1 937 0 1409 AP2B1_RAT reviewed AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) Ap2b1 Clapb1 Rattus norvegicus (Rat) 937 aorta development [GO:0035904]; clathrin coat assembly [GO:0048268]; coronary vasculature development [GO:0060976]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; ventricular septum development [GO:0003281] GO:0003281; GO:0005802; GO:0005886; GO:0005905; GO:0006886; GO:0006897; GO:0008565; GO:0030118; GO:0030119; GO:0030131; GO:0030276; GO:0032403; GO:0035904; GO:0048268; GO:0060976 0 0 0 PF01602;PF02883;PF09066; P63018 CHOYP_HSP7C.1.2 m.22077 sp HSP7C_RAT 80.13 614 121 1 1 614 1 613 0 1028 HSP7C_RAT reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) Hspa8 Hsc70 Hsc73 Rattus norvegicus (Rat) 646 "aging [GO:0007568]; axo-dendritic transport [GO:0008088]; cellular protein complex disassembly [GO:0043624]; cellular response to cadmium ion [GO:0071276]; cellular response to heat [GO:0034605]; cerebellum development [GO:0021549]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; chaperone-mediated protein folding [GO:0061077]; chaperone mediated protein folding requiring cofactor [GO:0051085]; chaperone-mediated protein transport involved in chaperone-mediated autophagy [GO:0061741]; clathrin coat disassembly [GO:0072318]; estrous cycle [GO:0044849]; forebrain development [GO:0030900]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular protein transmembrane import [GO:0044743]; kidney development [GO:0001822]; mRNA processing [GO:0006397]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of catalytic activity [GO:0043085]; positive regulation of gene expression [GO:0010628]; positive regulation of lysosomal membrane permeability [GO:0097214]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein refolding [GO:1904592]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein refolding [GO:0042026]; regulation of protein complex stability [GO:0061635]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to nickel cation [GO:0010045]; response to odorant [GO:1990834]; response to progesterone [GO:0032570]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; sensory perception of smell [GO:0007608]; skeletal muscle tissue development [GO:0007519]; slow axonal transport [GO:1990832]; transcription, DNA-templated [GO:0006351]" GO:0000082; GO:0000974; GO:0001822; GO:0001916; GO:0001917; GO:0003723; GO:0005102; GO:0005524; GO:0005634; GO:0005681; GO:0005730; GO:0005737; GO:0005764; GO:0005765; GO:0005776; GO:0005829; GO:0005874; GO:0005882; GO:0005886; GO:0006351; GO:0006397; GO:0006606; GO:0007519; GO:0007568; GO:0007608; GO:0008021; GO:0008088; GO:0008134; GO:0008380; GO:0009408; GO:0009986; GO:0010045; GO:0010628; GO:0010667; GO:0014069; GO:0014823; GO:0016887; GO:0019899; GO:0021549; GO:0030424; GO:0030425; GO:0030529; GO:0030900; GO:0031686; GO:0032279; GO:0032355; GO:0032570; GO:0034605; GO:0042026; GO:0042277; GO:0042470; GO:0042493; GO:0042594; GO:0042623; GO:0043005; GO:0043025; GO:0043085; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0043234; GO:0043531; GO:0043624; GO:0044743; GO:0044849; GO:0045121; GO:0045471; GO:0045862; GO:0045892; GO:0046777; GO:0048471; GO:0050766; GO:0051082; GO:0051085; GO:0061077; GO:0061635; GO:0061684; GO:0061741; GO:0070062; GO:0071276; GO:0072318; GO:0097214; GO:1903206; GO:1904592; GO:1904593; GO:1904764; GO:1990124; GO:1990832; GO:1990833; GO:1990834; GO:1990836 0 0 0 PF00012; P63018 CHOYP_HSP7D.3.3 m.41777 sp HSP7C_RAT 88.469 529 57 1 1 529 61 585 0 969 HSP7C_RAT reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) Hspa8 Hsc70 Hsc73 Rattus norvegicus (Rat) 646 "aging [GO:0007568]; axo-dendritic transport [GO:0008088]; cellular protein complex disassembly [GO:0043624]; cellular response to cadmium ion [GO:0071276]; cellular response to heat [GO:0034605]; cerebellum development [GO:0021549]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; chaperone-mediated protein folding [GO:0061077]; chaperone mediated protein folding requiring cofactor [GO:0051085]; chaperone-mediated protein transport involved in chaperone-mediated autophagy [GO:0061741]; clathrin coat disassembly [GO:0072318]; estrous cycle [GO:0044849]; forebrain development [GO:0030900]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular protein transmembrane import [GO:0044743]; kidney development [GO:0001822]; mRNA processing [GO:0006397]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of catalytic activity [GO:0043085]; positive regulation of gene expression [GO:0010628]; positive regulation of lysosomal membrane permeability [GO:0097214]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein refolding [GO:1904592]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein refolding [GO:0042026]; regulation of protein complex stability [GO:0061635]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to nickel cation [GO:0010045]; response to odorant [GO:1990834]; response to progesterone [GO:0032570]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; sensory perception of smell [GO:0007608]; skeletal muscle tissue development [GO:0007519]; slow axonal transport [GO:1990832]; transcription, DNA-templated [GO:0006351]" GO:0000082; GO:0000974; GO:0001822; GO:0001916; GO:0001917; GO:0003723; GO:0005102; GO:0005524; GO:0005634; GO:0005681; GO:0005730; GO:0005737; GO:0005764; GO:0005765; GO:0005776; GO:0005829; GO:0005874; GO:0005882; GO:0005886; GO:0006351; GO:0006397; GO:0006606; GO:0007519; GO:0007568; GO:0007608; GO:0008021; GO:0008088; GO:0008134; GO:0008380; GO:0009408; GO:0009986; GO:0010045; GO:0010628; GO:0010667; GO:0014069; GO:0014823; GO:0016887; GO:0019899; GO:0021549; GO:0030424; GO:0030425; GO:0030529; GO:0030900; GO:0031686; GO:0032279; GO:0032355; GO:0032570; GO:0034605; GO:0042026; GO:0042277; GO:0042470; GO:0042493; GO:0042594; GO:0042623; GO:0043005; GO:0043025; GO:0043085; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0043234; GO:0043531; GO:0043624; GO:0044743; GO:0044849; GO:0045121; GO:0045471; GO:0045862; GO:0045892; GO:0046777; GO:0048471; GO:0050766; GO:0051082; GO:0051085; GO:0061077; GO:0061635; GO:0061684; GO:0061741; GO:0070062; GO:0071276; GO:0072318; GO:0097214; GO:1903206; GO:1904592; GO:1904593; GO:1904764; GO:1990124; GO:1990832; GO:1990833; GO:1990834; GO:1990836 0 0 0 PF00012; P63329 CHOYP_CNA1.1.1 m.65403 sp PP2BA_RAT 80.785 484 82 2 5 478 8 490 0 840 PP2BA_RAT reviewed Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform) Ppp3ca Calna Rattus norvegicus (Rat) 521 calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion transport [GO:0006816]; cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to drug [GO:0035690]; cellular response to glucose stimulus [GO:0071333]; excitatory postsynaptic potential [GO:0060079]; G1/S transition of mitotic cell cycle [GO:0000082]; modulation of synaptic transmission [GO:0050804]; multicellular organismal response to stress [GO:0033555]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of chromatin binding [GO:0035562]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of insulin secretion [GO:0046676]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein dephosphorylation [GO:0006470]; protein import into nucleus [GO:0006606]; response to amphetamine [GO:0001975]; response to calcium ion [GO:0051592]; skeletal muscle fiber development [GO:0048741]; transition between fast and slow fiber [GO:0014883] GO:0000082; GO:0001975; GO:0004721; GO:0004722; GO:0004723; GO:0005516; GO:0005654; GO:0005739; GO:0005829; GO:0005955; GO:0006470; GO:0006606; GO:0006816; GO:0008144; GO:0014883; GO:0014898; GO:0016020; GO:0030018; GO:0033173; GO:0033192; GO:0033555; GO:0035562; GO:0035690; GO:0042383; GO:0045944; GO:0045955; GO:0046676; GO:0046872; GO:0046982; GO:0048741; GO:0050774; GO:0050804; GO:0051091; GO:0051533; GO:0051592; GO:0060079; GO:0071333; GO:0098794; GO:1903244 0 0 0 PF00149; P67963 CHOYP_KC1A.2.2 m.64030 sp KC1A_XENLA 91.195 318 28 0 4 321 2 319 0 614 KC1A_XENLA reviewed Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) csnk1a1 Xenopus laevis (African clawed frog) 337 cell division [GO:0051301]; intermediate filament cytoskeleton organization [GO:0045104]; mitotic nuclear division [GO:0007067]; protein phosphorylation [GO:0006468]; Wnt signaling pathway [GO:0016055] GO:0000777; GO:0004674; GO:0005524; GO:0005737; GO:0005815; GO:0006468; GO:0007067; GO:0016055; GO:0016607; GO:0045104; GO:0051301 0 0 0 PF00069; P67999 CHOYP_KS6B1.1.1 m.8274 sp KS6B1_RAT 62.722 507 167 5 1 491 24 524 0 615 KS6B1_RAT reviewed Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) Rps6kb1 Rattus norvegicus (Rat) 525 aging [GO:0007568]; apoptotic process [GO:0006915]; behavioral fear response [GO:0001662]; cell migration [GO:0016477]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hormone stimulus [GO:0032870]; cellular response to organic cyclic compound [GO:0071407]; G1/S transition of mitotic cell cycle [GO:0000082]; germ cell development [GO:0007281]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of translational initiation [GO:0045948]; protein kinase B signaling [GO:0043491]; protein phosphorylation [GO:0006468]; regulation of glucose import [GO:0046324]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878]; response to ethanol [GO:0045471]; response to glucagon [GO:0033762]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to insulin [GO:0032868]; response to leucine [GO:0043201]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; response to organonitrogen compound [GO:0010243]; response to peptide hormone [GO:0043434]; response to testosterone [GO:0033574]; response to toxic substance [GO:0009636]; response to tumor necrosis factor [GO:0034612]; response to wounding [GO:0009611]; skeletal muscle atrophy [GO:0014732]; skeletal muscle contraction [GO:0003009]; TOR signaling [GO:0031929] GO:0000082; GO:0001662; GO:0003009; GO:0004672; GO:0004711; GO:0004712; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0005741; GO:0005829; GO:0006468; GO:0006915; GO:0007281; GO:0007568; GO:0007584; GO:0007616; GO:0009408; GO:0009611; GO:0009612; GO:0009636; GO:0009749; GO:0009986; GO:0010033; GO:0010243; GO:0014070; GO:0014732; GO:0014878; GO:0014911; GO:0016477; GO:0030054; GO:0030165; GO:0031929; GO:0032496; GO:0032868; GO:0032870; GO:0033574; GO:0033762; GO:0034612; GO:0035556; GO:0042277; GO:0042493; GO:0042802; GO:0043005; GO:0043200; GO:0043201; GO:0043434; GO:0043491; GO:0045202; GO:0045471; GO:0045931; GO:0045948; GO:0046324; GO:0046627; GO:0048471; GO:0048633; GO:0048661; GO:0051384; GO:0051721; GO:0071363; GO:0071407; GO:2001237 0 0 cd05584; PF00069;PF00433; P68370 CHOYP_TBA1.8.9 m.61527 sp TBA1A_RAT 97.561 451 11 0 1 451 1 451 0 931 TBA1A_RAT reviewed Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tuba1a Tuba1 Rattus norvegicus (Rat) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005874; GO:0005881; GO:0007017; GO:0019904; GO:0036464; GO:0043209; GO:0046982; GO:0055037; GO:0070062 0 0 0 PF00091;PF03953; P68370 CHOYP_TBA1A.1.4 m.5565 sp TBA1A_RAT 98 350 7 0 1 350 1 350 0 731 TBA1A_RAT reviewed Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tuba1a Tuba1 Rattus norvegicus (Rat) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005874; GO:0005881; GO:0007017; GO:0019904; GO:0036464; GO:0043209; GO:0046982; GO:0055037; GO:0070062 0 0 0 PF00091;PF03953; P68370 CHOYP_TBA1A.2.4 m.19574 sp TBA1A_RAT 97.992 249 5 0 1 249 1 249 0 518 TBA1A_RAT reviewed Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tuba1a Tuba1 Rattus norvegicus (Rat) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005874; GO:0005881; GO:0007017; GO:0019904; GO:0036464; GO:0043209; GO:0046982; GO:0055037; GO:0070062 0 0 0 PF00091;PF03953; P68370 CHOYP_TBA1A.3.4 m.25622 sp TBA1A_RAT 97.305 334 9 0 1 334 1 334 0 687 TBA1A_RAT reviewed Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tuba1a Tuba1 Rattus norvegicus (Rat) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005874; GO:0005881; GO:0007017; GO:0019904; GO:0036464; GO:0043209; GO:0046982; GO:0055037; GO:0070062 0 0 0 PF00091;PF03953; P68370 CHOYP_TBA1A.4.4 m.40949 sp TBA1A_RAT 97.861 374 8 0 1 374 1 374 0 776 TBA1A_RAT reviewed Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tuba1a Tuba1 Rattus norvegicus (Rat) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005874; GO:0005881; GO:0007017; GO:0019904; GO:0036464; GO:0043209; GO:0046982; GO:0055037; GO:0070062 0 0 0 PF00091;PF03953; P68370 CHOYP_TBA2.1.1 m.955 sp TBA1A_RAT 97.555 409 10 0 1 409 43 451 0 840 TBA1A_RAT reviewed Tubulin alpha-1A chain (Alpha-tubulin 1) (Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tuba1a Tuba1 Rattus norvegicus (Rat) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005874; GO:0005881; GO:0007017; GO:0019904; GO:0036464; GO:0043209; GO:0046982; GO:0055037; GO:0070062 0 0 0 PF00091;PF03953; P68372 CHOYP_BRAFLDRAFT_60807.1.2 m.25890 sp TBB4B_MOUSE 96.382 387 12 1 1 387 1 385 0 792 TBB4B_MOUSE reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Mus musculus (Mouse) 445 microtubule-based process [GO:0007017] GO:0003725; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005874; GO:0007017; GO:0043209; GO:0045298; GO:0070062; GO:1903561 0 0 0 PF00091;PF03953; P68372 CHOYP_BRAFLDRAFT_60807.1.2 m.25891 sp TBB4B_MOUSE 97.338 263 7 0 1 263 1 263 0 544 TBB4B_MOUSE reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Mus musculus (Mouse) 445 microtubule-based process [GO:0007017] GO:0003725; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005874; GO:0007017; GO:0043209; GO:0045298; GO:0070062; GO:1903561 0 0 0 PF00091;PF03953; P68372 CHOYP_LOC373275.3.7 m.38055 sp TBB4B_MOUSE 90.274 401 28 1 43 432 1 401 0 737 TBB4B_MOUSE reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Mus musculus (Mouse) 445 microtubule-based process [GO:0007017] GO:0003725; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005874; GO:0007017; GO:0043209; GO:0045298; GO:0070062; GO:1903561 0 0 0 PF00091;PF03953; P68372 CHOYP_TBB4B.2.7 m.12353 sp TBB4B_MOUSE 98.626 364 5 0 1 364 73 436 0 761 TBB4B_MOUSE reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Mus musculus (Mouse) 445 microtubule-based process [GO:0007017] GO:0003725; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005874; GO:0007017; GO:0043209; GO:0045298; GO:0070062; GO:1903561 0 0 0 PF00091;PF03953; P70080 CHOYP_TPH1.1.1 m.6702 sp TPH1_CHICK 76.308 325 76 1 2 325 120 444 0 536 TPH1_CHICK reviewed Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) TPH1 TPH Gallus gallus (Chicken) 445 aromatic amino acid family metabolic process [GO:0009072]; bone remodeling [GO:0046849]; positive regulation of fat cell differentiation [GO:0045600]; serotonin biosynthetic process [GO:0042427] GO:0004510; GO:0005506; GO:0005737; GO:0009072; GO:0016597; GO:0042427; GO:0045600; GO:0046849 PATHWAY: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. 0 0 PF00351; P70099 CHOYP_RAD51.1.1 m.11855 sp RAD51_CRIGR 88.201 339 39 1 19 356 1 339 0 622 RAD51_CRIGR reviewed DNA repair protein RAD51 homolog 1 RAD51 RAD51A Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 339 cellular response to camptothecin [GO:0072757]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to ionizing radiation [GO:0071479]; DNA recombinase assembly [GO:0000730]; DNA unwinding involved in DNA replication [GO:0006268]; double-strand break repair via homologous recombination [GO:0000724]; meiotic nuclear division [GO:0007126]; mitotic recombination-dependent replication fork processing [GO:1990426]; regulation of double-strand break repair via homologous recombination [GO:0010569] GO:0000150; GO:0000228; GO:0000724; GO:0000730; GO:0000793; GO:0000794; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005737; GO:0005759; GO:0005815; GO:0006268; GO:0006974; GO:0007126; GO:0010569; GO:0043142; GO:0048471; GO:0071479; GO:0072757; GO:1990426 0 0 0 PF08423; P70187 CHOYP_HIAT1.1.1 m.63549 sp MF14A_MOUSE 60 495 182 4 7 496 6 489 0 587 MF14A_MOUSE reviewed Hippocampus abundant transcript 1 protein (Major facilitator superfamily domain-containing 14A) Mfsd14a Hiat1 Mus musculus (Mouse) 490 transmembrane transport [GO:0055085] GO:0005215; GO:0016021; GO:0055085 0 0 cd06174; PF07690; P70388 CHOYP_RAD50.3.4 m.33808 sp RAD50_MOUSE 44.234 1318 719 7 1 1311 1 1309 0 1085 RAD50_MOUSE reviewed DNA repair protein RAD50 (mRad50) (EC 3.6.-.-) Rad50 Mus musculus (Mouse) 1312 cellular response to DNA damage stimulus [GO:0006974]; chromosome organization [GO:0051276]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere capping [GO:1904354]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic recombination [GO:0000019]; telomere capping [GO:0016233]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860] GO:0000019; GO:0000722; GO:0000724; GO:0000784; GO:0000790; GO:0000794; GO:0003677; GO:0003691; GO:0004017; GO:0005524; GO:0005634; GO:0005654; GO:0006281; GO:0006302; GO:0006310; GO:0006974; GO:0007004; GO:0007131; GO:0007346; GO:0016020; GO:0016233; GO:0016887; GO:0030674; GO:0030870; GO:0031860; GO:0031954; GO:0032206; GO:0032508; GO:0033674; GO:0035861; GO:0043047; GO:0045120; GO:0046872; GO:0051276; GO:0051880; GO:0070192; GO:0090305; GO:1904354 0 0 0 PF04423; P70428 CHOYP_EXT2.1.1 m.52229 sp EXT2_MOUSE 55.177 705 305 6 1 698 18 718 0 807 EXT2_MOUSE reviewed Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog) Ext2 Mus musculus (Mouse) 718 "cell differentiation [GO:0030154]; cellular polysaccharide biosynthetic process [GO:0033692]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; mesoderm formation [GO:0001707]; ossification [GO:0001503]; protein glycosylation [GO:0006486]" GO:0000139; GO:0001503; GO:0001707; GO:0005783; GO:0005789; GO:0005794; GO:0006024; GO:0006486; GO:0008375; GO:0015012; GO:0015014; GO:0015020; GO:0016020; GO:0016021; GO:0016757; GO:0030154; GO:0033692; GO:0042328; GO:0042803; GO:0043541; GO:0046872; GO:0046982; GO:0050508; GO:0050509; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03016;PF09258; P70531 CHOYP_LOC100376880.1.1 m.475 sp EF2K_RAT 49.77 651 275 13 90 698 84 724 0 575 EF2K_RAT reviewed Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase) Eef2k Rattus norvegicus (Rat) 724 cellular response to anoxia [GO:0071454]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to calcium ion [GO:0071277]; cellular response to cAMP [GO:0071320]; cellular response to insulin stimulus [GO:0032869]; negative regulation of apoptotic process [GO:0043066]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of endocytosis [GO:0045807]; positive regulation of synapse assembly [GO:0051965]; protein autophosphorylation [GO:0046777]; regulation of protein autophosphorylation [GO:0031952]; response to ischemia [GO:0002931]; response to prolactin [GO:1990637] GO:0002931; GO:0004686; GO:0005509; GO:0005516; GO:0005524; GO:0014069; GO:0031952; GO:0032869; GO:0043066; GO:0045807; GO:0046777; GO:0051965; GO:0061003; GO:0071277; GO:0071320; GO:0071454; GO:1990416; GO:1990637 0 0 0 PF02816;PF08238; P70549 CHOYP_LOC100368666.1.1 m.43153 sp NAC3_RAT 55.605 901 364 13 28 906 38 924 0 987 NAC3_RAT reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Rattus norvegicus (Rat) 927 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005739; GO:0005741; GO:0005789; GO:0005874; GO:0005886; GO:0005887; GO:0006814; GO:0006851; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0016528; GO:0021537; GO:0030054; GO:0031594; GO:0042383; GO:0042552; GO:0042995; GO:0043025; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0071320; GO:0071456; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; P70627 CHOYP_LOC579656.5.5 m.62444 sp FOLH1_RAT 43.885 695 371 10 107 787 62 751 0 605 FOLH1_RAT reviewed Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen homolog) (Pteroylpoly-gamma-glutamate carboxypeptidase) Folh1 Naalad1 Rattus norvegicus (Rat) 752 positive regulation of apoptotic process [GO:0043065]; proteolysis [GO:0006508] GO:0004180; GO:0005886; GO:0006508; GO:0008237; GO:0016021; GO:0016805; GO:0043065; GO:0046872 0 0 0 PF02225;PF04389;PF04253; P70705 CHOYP_ATP7A.1.1 m.23099 sp ATP7A_RAT 48.451 1517 674 19 15 1462 14 1491 0 1320 ATP7A_RAT reviewed Copper-transporting ATPase 1 (EC 3.6.3.54) (Copper pump 1) (Menkes disease-associated protein homolog) Atp7a Mnk Rattus norvegicus (Rat) 1492 cellular copper ion homeostasis [GO:0006878]; cellular response to amino acid stimulus [GO:0071230]; cellular response to antibiotic [GO:0071236]; cellular response to cobalt ion [GO:0071279]; cellular response to copper ion [GO:0071280]; cellular response to hypoxia [GO:0071456]; cellular response to iron ion [GO:0071281]; cellular response to lead ion [GO:0071284]; cellular response to manganese ion [GO:0071287]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; copper ion export [GO:0060003]; in utero embryonic development [GO:0001701]; lactation [GO:0007595]; liver development [GO:0001889]; negative regulation of iron ion transmembrane transport [GO:0034760]; plasma membrane copper ion transport [GO:0015679]; positive regulation of cell size [GO:0045793]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of oxidoreductase activity [GO:0051353]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of cytochrome-c oxidase activity [GO:1904959]; regulation of gene expression [GO:0010468]; response to copper ion [GO:0046688]; response to iron(III) ion [GO:0010041]; response to lead ion [GO:0010288]; response to zinc ion [GO:0010043] GO:0001701; GO:0001889; GO:0004008; GO:0005375; GO:0005507; GO:0005524; GO:0005770; GO:0005794; GO:0005802; GO:0005886; GO:0005887; GO:0006878; GO:0007595; GO:0010041; GO:0010043; GO:0010288; GO:0010468; GO:0010592; GO:0015679; GO:0016021; GO:0016323; GO:0030140; GO:0030141; GO:0031252; GO:0031526; GO:0034760; GO:0036120; GO:0043204; GO:0045793; GO:0046688; GO:0048471; GO:0050679; GO:0051087; GO:0051353; GO:0060003; GO:0071230; GO:0071236; GO:0071279; GO:0071280; GO:0071281; GO:0071284; GO:0071287; GO:0071456; GO:1904754; GO:1904959 0 0 0 PF00122;PF00403; P78316 CHOYP_LOC100368659.1.2 m.15836 sp NOP14_HUMAN 44.368 870 407 24 24 868 30 847 0 604 NOP14_HUMAN reviewed Nucleolar protein 14 (Nucleolar complex protein 14) NOP14 C4orf9 NOL14 RES4-25 Homo sapiens (Human) 857 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005634; GO:0005654; GO:0005730; GO:0005739; GO:0006364; GO:0016020; GO:0019899; GO:0030490; GO:0030515; GO:0030686; GO:0030692; GO:0032040; GO:0042274; GO:0044822 0 0 0 PF04147; P78527 CHOYP_NEMVEDRAFT_V1G126379.2.2 m.43168 sp PRKDC_HUMAN 44.46 722 363 16 9 709 376 1080 0 585 PRKDC_HUMAN reviewed DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) PRKDC HYRC HYRC1 Homo sapiens (Human) 4128 B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cell proliferation [GO:0008283]; cellular protein modification process [GO:0006464]; cellular response to insulin stimulus [GO:0032869]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immunoglobulin V(D)J recombination [GO:0033152]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of immunoglobulin production [GO:0002638]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of response to gamma radiation [GO:2001229]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of developmental growth [GO:0048639]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of immune system process [GO:0002684]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; regulation of smooth muscle cell proliferation [GO:0048660]; response to activity [GO:0014823]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431]; somitogenesis [GO:0001756]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere capping [GO:0016233]; thymus development [GO:0048538] GO:0000784; GO:0001756; GO:0001933; GO:0002326; GO:0002328; GO:0002360; GO:0002638; GO:0002684; GO:0003690; GO:0004672; GO:0004674; GO:0004677; GO:0005524; GO:0005654; GO:0005667; GO:0005730; GO:0005829; GO:0005958; GO:0006302; GO:0006303; GO:0006464; GO:0007420; GO:0007507; GO:0008134; GO:0008283; GO:0008630; GO:0010332; GO:0014823; GO:0016020; GO:0016233; GO:0018105; GO:0031012; GO:0031648; GO:0032481; GO:0032869; GO:0033077; GO:0033152; GO:0033153; GO:0035234; GO:0042752; GO:0043065; GO:0043066; GO:0044822; GO:0045944; GO:0048146; GO:0048511; GO:0048536; GO:0048538; GO:0048639; GO:0048660; GO:0070419; GO:0072431; GO:0097681; GO:2000773; GO:2001229 0 0 0 PF02259;PF02260;PF08163;PF00454; P79098 CHOYP_LOC100741250.1.2 m.48951 sp AMPN_BOVIN 41.593 904 487 15 1029 1905 72 961 0 711 AMPN_BOVIN reviewed Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) 965 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P79098 CHOYP_LOC100874903.1.1 m.39757 sp AMPN_BOVIN 41.345 907 484 15 134 1008 71 961 0 717 AMPN_BOVIN reviewed Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) 965 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P79098 CHOYP_LOC409619.1.4 m.13984 sp AMPN_BOVIN 39.078 911 509 14 1031 1913 72 964 0 676 AMPN_BOVIN reviewed Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) 965 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P79098 CHOYP_LOC409619.2.4 m.24769 sp AMPN_BOVIN 41.685 914 478 18 262 1140 72 965 0 719 AMPN_BOVIN reviewed Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) 965 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P79098 CHOYP_LOC409619.3.4 m.32171 sp AMPN_BOVIN 41.832 906 482 15 1926 2802 72 961 0 717 AMPN_BOVIN reviewed Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) 965 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P79098 CHOYP_LOC409619.4.4 m.66578 sp AMPN_BOVIN 41.584 909 479 17 134 1008 71 961 0 717 AMPN_BOVIN reviewed Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) 965 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P79101 CHOYP_BRAFLDRAFT_282200.1.1 m.18115 sp CPSF3_BOVIN 71.889 683 184 4 7 682 2 683 0 1036 CPSF3_BOVIN reviewed Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) CPSF3 CPSF73 Bos taurus (Bovine) 684 mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398] GO:0003723; GO:0004521; GO:0005847; GO:0006398; GO:0008409; GO:0030529; GO:0046872 0 0 0 PF10996;PF11718;PF00753;PF07521; P79134 CHOYP_ANXA6.1.2 m.6559 sp ANXA6_BOVIN 45.373 670 348 6 432 1094 12 670 0 579 ANXA6_BOVIN reviewed Annexin A6 (Annexin VI) (Annexin-6) ANXA6 ANX6 Bos taurus (Bovine) 673 apoptotic signaling pathway [GO:0097190]; biomineral tissue development [GO:0031214]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; growth plate cartilage chondrocyte differentiation [GO:0003418]; mitochondrial calcium ion homeostasis [GO:0051560]; negative regulation of sequestering of calcium ion [GO:0051283]; protein homooligomerization [GO:0051260]; regulation of muscle contraction [GO:0006937] GO:0001725; GO:0001786; GO:0003418; GO:0004872; GO:0005262; GO:0005509; GO:0005525; GO:0005544; GO:0005737; GO:0005765; GO:0005829; GO:0005886; GO:0005925; GO:0006816; GO:0006937; GO:0008201; GO:0015276; GO:0015485; GO:0016020; GO:0016021; GO:0019899; GO:0030061; GO:0031214; GO:0031902; GO:0031988; GO:0035374; GO:0042470; GO:0042584; GO:0042802; GO:0048306; GO:0048471; GO:0051015; GO:0051260; GO:0051283; GO:0051560; GO:0070062; GO:0070509; GO:0070588; GO:0097190 0 0 0 PF00191; P79171 CHOYP_LOC100741250.2.2 m.65085 sp AMPN_FELCA 37.376 907 528 13 621 1503 73 963 0 659 AMPN_FELCA reviewed Aminopeptidase N (AP-N) (fAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Felis catus (Cat) (Felis silvestris catus) 967 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P79334 CHOYP_PYGM.1.1 m.47027 sp PYGM_BOVIN 69.185 834 255 1 9 840 8 841 0 1203 PYGM_BOVIN reviewed "Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)" PYGM Bos taurus (Bovine) 842 glycogen catabolic process [GO:0005980] GO:0000166; GO:0005737; GO:0005980; GO:0008184; GO:0030170 0 0 cd04300; PF00343; P80021 CHOYP_ATPA.1.1 m.50245 sp ATPA_PIG 83.459 532 88 0 58 589 21 552 0 916 ATPA_PIG reviewed "ATP synthase subunit alpha, mitochondrial (ATP synthase subunit alpha heart isoform, mitochondrial) (ATP synthase subunit alpha liver isoform, mitochondrial)" ATP5A1 ATP5A2 Sus scrofa (Pig) 553 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0005524; GO:0005743; GO:0005886; GO:0015986; GO:0015991; GO:0045261; GO:0046933; GO:0046961 0 0 cd01132; PF00006;PF00306;PF02874; P80404 CHOYP_CAN5.1.1 m.42243 sp GABT_HUMAN 51.02 490 231 2 20 500 9 498 0 534 GABT_HUMAN reviewed "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Homo sapiens (Human) 500 aging [GO:0007568]; behavioral response to cocaine [GO:0048148]; cerebellum development [GO:0021549]; copulation [GO:0007620]; exploration behavior [GO:0035640]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; gamma-aminobutyric acid catabolic process [GO:0009450]; locomotory behavior [GO:0007626]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of platelet aggregation [GO:0090331]; neurotransmitter catabolic process [GO:0042135]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of heat generation [GO:0031652]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of uterine smooth muscle contraction [GO:0070474]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094] GO:0001666; GO:0003867; GO:0005739; GO:0005759; GO:0007568; GO:0007620; GO:0007626; GO:0009449; GO:0009450; GO:0010039; GO:0014053; GO:0021549; GO:0030170; GO:0031652; GO:0032024; GO:0032144; GO:0032145; GO:0033602; GO:0035094; GO:0035640; GO:0042135; GO:0042493; GO:0042803; GO:0043005; GO:0045471; GO:0045776; GO:0045964; GO:0046872; GO:0047298; GO:0048148; GO:0051536; GO:0070062; GO:0070474; GO:0090331; GO:0097151; GO:1902722; GO:1904450 0 0 cd00610; PF00202; P81133 CHOYP_SIM2.1.1 m.13843 sp SIM1_HUMAN 75.135 370 89 2 1 368 1 369 0 587 SIM1_HUMAN reviewed Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14) SIM1 BHLHE14 Homo sapiens (Human) 766 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; ureteric bud development [GO:0001657]" GO:0000981; GO:0001657; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0007399; GO:0030154 0 0 0 PF00010;PF00989;PF08447;PF06621; P81274 CHOYP_GPSM2.1.1 m.58301 sp GPSM2_HUMAN 57.098 641 221 8 3 590 13 652 0 720 GPSM2_HUMAN reviewed G-protein-signaling modulator 2 (Mosaic protein LGN) GPSM2 LGN Homo sapiens (Human) 684 establishment of mitotic spindle orientation [GO:0000132]; G-protein coupled receptor signaling pathway [GO:0007186]; lung epithelial cell differentiation [GO:0060487]; maintenance of centrosome location [GO:0051661]; mitotic spindle organization [GO:0007052] GO:0000132; GO:0000166; GO:0000922; GO:0005092; GO:0005737; GO:0005938; GO:0007052; GO:0007186; GO:0042802; GO:0045177; GO:0051661; GO:0060487 0 0 0 PF02188;PF13176;PF13181; P81431 CHOYP_ADHX.1.1 m.60159 sp ADHX_OCTVU 76.267 375 89 0 18 392 2 376 0 612 ADHX_OCTVU reviewed Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) 0 Octopus vulgaris (Common octopus) 378 ethanol oxidation [GO:0006069] GO:0004022; GO:0005737; GO:0006069; GO:0008270; GO:0051903 0 0 cd08300; PF08240;PF00107; P82808 CHOYP_PHUM_PHUM536560.1.2 m.12360 sp GFPT1_RAT 70.849 518 144 3 1 513 1 516 0 758 GFPT1_RAT reviewed Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) Gfpt1 Rattus norvegicus (Rat) 681 carbohydrate metabolic process [GO:0005975]; cellular response to insulin stimulus [GO:0032869]; circadian regulation of gene expression [GO:0032922]; fructose 6-phosphate metabolic process [GO:0006002]; glucosamine biosynthetic process [GO:0006042]; glutamine metabolic process [GO:0006541]; negative regulation of glycogen biosynthetic process [GO:0045719]; protein homotetramerization [GO:0051289]; response to insulin [GO:0032868]; response to sucrose [GO:0009744]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] GO:0004360; GO:0005975; GO:0006002; GO:0006042; GO:0006047; GO:0006048; GO:0006541; GO:0009744; GO:0016597; GO:0030246; GO:0032868; GO:0032869; GO:0032922; GO:0045719; GO:0051289 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000305|PubMed:10898949}. 0 0 PF01380; P83436 CHOYP_LOC581128.1.1 m.46711 sp COG7_HUMAN 43.355 775 409 12 17 768 1 768 0 640 COG7_HUMAN reviewed Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) COG7 UNQ3082/PRO10013 Homo sapiens (Human) 770 "ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to Golgi apparatus [GO:0034067]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005730; GO:0005794; GO:0006486; GO:0006886; GO:0006888; GO:0006890; GO:0007030; GO:0017119; GO:0032588; GO:0033365; GO:0034067; GO:0043231; GO:0050821 0 0 0 PF10191; P84025 CHOYP_SMAD3.1.1 m.51679 sp SMAD3_RAT 76.941 425 87 3 1 414 1 425 0 674 SMAD3_RAT reviewed Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (SMAD family member 3) (SMAD 3) (Smad3) Smad3 Madh3 Rattus norvegicus (Rat) 425 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; canonical Wnt signaling pathway [GO:0060070]; cell-cell junction organization [GO:0045216]; cell cycle arrest [GO:0007050]; developmental growth [GO:0048589]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic foregut morphogenesis [GO:0048617]; embryonic pattern specification [GO:0009880]; endoderm development [GO:0007492]; evasion or tolerance of host defenses by virus [GO:0019049]; extrinsic apoptotic signaling pathway [GO:0097191]; heart looping [GO:0001947]; immune response [GO:0006955]; immune system development [GO:0002520]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; lens fiber cell differentiation [GO:0070306]; liver development [GO:0001889]; mesoderm formation [GO:0001707]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of wound healing [GO:0061045]; nodal signaling pathway [GO:0038092]; osteoblast development [GO:0002076]; paraxial mesoderm morphogenesis [GO:0048340]; pericardium development [GO:0060039]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of cell migration [GO:0030335]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transforming growth factor beta3 production [GO:0032916]; protein stabilization [GO:0050821]; regulation of binding [GO:0051098]; regulation of epithelial cell proliferation [GO:0050678]; regulation of immune response [GO:0050776]; regulation of striated muscle tissue development [GO:0016202]; regulation of transforming growth factor beta2 production [GO:0032909]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; signal transduction involved in regulation of gene expression [GO:0023019]; SMAD protein complex assembly [GO:0007183]; SMAD protein signal transduction [GO:0060395]; somitogenesis [GO:0001756]; T cell activation [GO:0042110]; thyroid gland development [GO:0030878]; transcription, DNA-templated [GO:0006351]; transdifferentiation [GO:0060290]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transport [GO:0006810]; ureteric bud development [GO:0001657]" GO:0000122; GO:0000790; GO:0000978; GO:0000983; GO:0000987; GO:0000988; GO:0001657; GO:0001666; GO:0001701; GO:0001707; GO:0001756; GO:0001889; GO:0001933; GO:0001947; GO:0002076; GO:0002520; GO:0003677; GO:0003700; GO:0005634; GO:0005637; GO:0005654; GO:0005667; GO:0005737; GO:0005886; GO:0006351; GO:0006810; GO:0006919; GO:0006955; GO:0007050; GO:0007179; GO:0007183; GO:0007492; GO:0008013; GO:0008134; GO:0008270; GO:0008285; GO:0009880; GO:0010694; GO:0010718; GO:0016202; GO:0017015; GO:0019049; GO:0019899; GO:0023019; GO:0030308; GO:0030335; GO:0030501; GO:0030618; GO:0030878; GO:0031490; GO:0032332; GO:0032731; GO:0032909; GO:0032916; GO:0033689; GO:0035413; GO:0035556; GO:0038092; GO:0042110; GO:0042177; GO:0042993; GO:0043066; GO:0043234; GO:0043235; GO:0043565; GO:0045216; GO:0045599; GO:0045668; GO:0045930; GO:0045944; GO:0046332; GO:0048340; GO:0048589; GO:0048617; GO:0048701; GO:0050678; GO:0050728; GO:0050776; GO:0050821; GO:0050927; GO:0051098; GO:0051496; GO:0051894; GO:0060039; GO:0060070; GO:0060290; GO:0060395; GO:0061045; GO:0070306; GO:0071141; GO:0071144; GO:0090263; GO:0097191; GO:0097296; GO:1901203 0 0 0 PF03165;PF03166; P85515 CHOYP_ACTZ.1.1 m.12877 sp ACTZ_RAT 85.942 377 52 1 1 377 1 376 0 691 ACTZ_RAT reviewed Alpha-centractin (Centractin) Actr1a Ctrn1 Rattus norvegicus (Rat) 376 0 GO:0005524; GO:0005737; GO:0005813; GO:0005869; GO:0043209; GO:0070062; GO:1990752 0 0 0 PF00022; P86785 CHOYP_GIGA2.1.1 m.44916 sp GIGA2_CRAGI 98.765 324 4 0 30 353 1 324 0 668 GIGA2_CRAGI reviewed Gigasin-2 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 340 0 0 0 0 0 0 P86789 CHOYP_GIGA6.1.1 m.38687 sp GIGA6_CRAGI 92.759 290 20 1 1 289 12 301 0 542 GIGA6_CRAGI reviewed Gigasin-6 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 302 0 GO:0016021 0 0 0 PF00144; P86955 CHOYP_CHI.1.1 m.42122 sp CHI_PINMA 55.484 465 206 1 7 471 3 466 0 561 CHI_PINMA reviewed Putative chitinase (EC 3.2.1.14) (Chitinase-like protein 3) (Clp3) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032] GO:0004568; GO:0005576; GO:0005975; GO:0006032 0 0 0 PF00704; P90666 CHOYP_TXND3.2.4 m.21415 sp TXND3_HELCR 45.524 782 366 9 1 745 1 759 0 657 TXND3_HELCR reviewed Thioredoxin domain-containing protein 3 homolog (Intermediate chain 1) (NME/NM23 family member 8) NME8 IC1 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 837 cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228] GO:0004550; GO:0005623; GO:0006183; GO:0006228; GO:0006241; GO:0007275; GO:0007283; GO:0030154; GO:0045454 0 0 0 PF00334;PF00085; P90666 CHOYP_TXND3.4.4 m.64014 sp TXND3_HELCR 45.396 782 362 10 1 740 1 759 0 643 TXND3_HELCR reviewed Thioredoxin domain-containing protein 3 homolog (Intermediate chain 1) (NME/NM23 family member 8) NME8 IC1 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 837 cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228] GO:0004550; GO:0005623; GO:0006183; GO:0006228; GO:0006241; GO:0007275; GO:0007283; GO:0030154; GO:0045454 0 0 0 PF00334;PF00085; P91119 CHOYP_TRIADDRAFT_21752.1.1 m.62548 sp PDE5_CAEEL 44.872 780 354 14 8 767 5 728 0 654 PDE5_CAEEL reviewed "Probable 3',5'-cyclic phosphodiesterase pde-5 (EC 3.1.4.17)" pde-5 C32E12.2 Caenorhabditis elegans 728 chemosensory behavior [GO:0007635]; chemotaxis [GO:0006935]; determination of adult lifespan [GO:0008340]; microvillus organization [GO:0032528]; negative regulation of cGMP biosynthetic process [GO:0030827]; negative regulation of cGMP-mediated signaling [GO:0010754]; phototransduction [GO:0007602]; positive regulation of gene expression [GO:0010628]; response to alkaline pH [GO:0010446]; response to hydrogen peroxide [GO:0042542] GO:0006935; GO:0007602; GO:0007635; GO:0008340; GO:0010446; GO:0010628; GO:0010754; GO:0030827; GO:0032528; GO:0042542; GO:0046872; GO:0047555 0 0 0 PF01590;PF00233; P91620 CHOYP_AGAP_AGAP006590.1.1 m.42108 sp SIF2_DROME 43.018 1153 515 23 688 1739 794 1905 0 848 SIF2_DROME reviewed "Protein still life, isoforms C/SIF type 2" sif CG34418 Drosophila melanogaster (Fruit fly) 2061 actin cytoskeleton organization [GO:0030036]; intracellular signal transduction [GO:0035556]; positive regulation of filopodium assembly [GO:0051491]; regulation of axonogenesis [GO:0050770]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synapse structure or activity [GO:0050803] GO:0005057; GO:0005622; GO:0030036; GO:0030054; GO:0030676; GO:0035023; GO:0035556; GO:0043087; GO:0045202; GO:0050770; GO:0050803; GO:0051491 0 0 0 PF00169;PF02196;PF00621; P91645 CHOYP_CAC1A.2.2 m.61810 sp CAC1A_DROME 39.396 1490 759 29 42 1410 5 1471 0 984 CAC1A_DROME reviewed Voltage-dependent calcium channel type A subunit alpha-1 (Protein cacophony) (Protein nightblind A) (Protein no-on-transient B) (Dmca1A) cac nbA nonB CG43368 Drosophila melanogaster (Fruit fly) 1851 "adult locomotory behavior [GO:0008344]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; courtship behavior [GO:0007619]; detection of light stimulus involved in visual perception [GO:0050908]; epithelial fluid transport [GO:0042045]; exocytosis [GO:0006887]; male courtship behavior, veined wing generated song production [GO:0045433]; membrane depolarization during action potential [GO:0086010]; multicellular organism development [GO:0007275]; neuron cellular homeostasis [GO:0070050]; neurotransmitter secretion [GO:0007269]; phototransduction [GO:0007602]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; regulation of heart rate [GO:0002027]; regulation of membrane potential in photoreceptor cell [GO:0016057]; regulation of neurotransmitter secretion [GO:0046928]; visual behavior [GO:0007632]" GO:0002027; GO:0005245; GO:0005509; GO:0005891; GO:0006816; GO:0006887; GO:0006914; GO:0007268; GO:0007269; GO:0007275; GO:0007602; GO:0007619; GO:0007632; GO:0008331; GO:0008332; GO:0008344; GO:0010524; GO:0016057; GO:0016323; GO:0016324; GO:0042045; GO:0045433; GO:0045887; GO:0046928; GO:0048786; GO:0050908; GO:0070050; GO:0086010; GO:0097352 0 0 0 PF08763;PF16905;PF00520; P91766 CHOYP_LOC100533250.2.2 m.35055 sp ACH1_MANSE 58.635 498 198 4 1 495 1 493 0 551 ACH1_MANSE reviewed Acetylcholine receptor subunit alpha-like (MARA1) ARA1 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 516 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; P91778 CHOYP_AMY.3.3 m.64271 sp AMY_PECMA 70.543 516 140 4 4 519 5 508 0 726 AMY_PECMA reviewed "Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)" 0 Pecten maximus (King scallop) (Pilgrim's clam) 508 carbohydrate metabolic process [GO:0005975] GO:0004556; GO:0005975; GO:0046872 0 0 0 PF00128;PF02806; P92208 CHOYP_JNK.1.1 m.1540 sp JNK_DROME 81.694 366 67 0 4 369 3 368 0 644 JNK_DROME reviewed Stress-activated protein kinase JNK (dJNK) (EC 2.7.11.24) (Protein basket) bsk JNK CG5680 Drosophila melanogaster (Fruit fly) 372 "antibacterial humoral response [GO:0019731]; axon extension [GO:0048675]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cellular response to arsenic-containing substance [GO:0071243]; cellular response to cadmium ion [GO:0071276]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; collateral sprouting of injured axon [GO:0048674]; determination of digestive tract left/right asymmetry [GO:0071907]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; embryonic anterior midgut (ectodermal) morphogenesis [GO:0048615]; engulfment of apoptotic cell [GO:0043652]; establishment of planar polarity [GO:0001736]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc fusion, thorax closure [GO:0046529]; JNK cascade [GO:0007254]; JUN phosphorylation [GO:0007258]; long-term memory [GO:0007616]; MAPK cascade [GO:0000165]; melanization defense response [GO:0035006]; micropyle formation [GO:0046844]; mushroom body development [GO:0016319]; negative regulation of JUN kinase activity [GO:0043508]; neuron development [GO:0048666]; neuron projection morphogenesis [GO:0048812]; ovarian follicle cell development [GO:0030707]; positive regulation of autophagy [GO:0010508]; positive regulation of border follicle cell migration [GO:1903688]; positive regulation of neuron remodeling [GO:1904801]; protein phosphorylation [GO:0006468]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]; wound healing, spreading of epidermal cells [GO:0035313]" GO:0000165; GO:0001736; GO:0004672; GO:0004674; GO:0004705; GO:0005524; GO:0005737; GO:0006468; GO:0006979; GO:0007254; GO:0007258; GO:0007298; GO:0007391; GO:0007411; GO:0007616; GO:0009408; GO:0010508; GO:0016055; GO:0016319; GO:0019731; GO:0030424; GO:0030425; GO:0030707; GO:0034599; GO:0034614; GO:0035006; GO:0035313; GO:0042060; GO:0043508; GO:0043652; GO:0046529; GO:0046843; GO:0046844; GO:0048615; GO:0048666; GO:0048674; GO:0048675; GO:0048803; GO:0048812; GO:0071243; GO:0071276; GO:0071907; GO:1903688; GO:1904801 0 0 0 PF00069; P97275 CHOYP_AGPS.1.1 m.62910 sp ADAS_CAVPO 68.621 580 182 0 35 614 79 658 0 897 ADAS_CAVPO reviewed "Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Alkylglycerone-phosphate synthase)" AGPS Cavia porcellus (Guinea pig) 658 ether lipid biosynthetic process [GO:0008611] GO:0005730; GO:0005739; GO:0005778; GO:0008609; GO:0008611; GO:0016614; GO:0071949 PATHWAY: Glycerolipid metabolism; ether lipid biosynthesis. 0 0 PF02913;PF01565; P97363 CHOYP_SPTC2.1.4 m.11547 sp SPTC2_MOUSE 55.388 529 231 3 68 594 14 539 0 603 SPTC2_MOUSE reviewed Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) Sptlc2 Lcb2 Mus musculus (Mouse) 560 ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] GO:0004758; GO:0005739; GO:0006686; GO:0016021; GO:0017059; GO:0030148; GO:0030170; GO:0046511; GO:0046512; GO:0046513; GO:1904504 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00155; P97363 CHOYP_SPTC2.2.4 m.21508 sp SPTC2_MOUSE 65.51 490 167 2 52 539 57 546 0 672 SPTC2_MOUSE reviewed Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) Sptlc2 Lcb2 Mus musculus (Mouse) 560 ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] GO:0004758; GO:0005739; GO:0006686; GO:0016021; GO:0017059; GO:0030148; GO:0030170; GO:0046511; GO:0046512; GO:0046513; GO:1904504 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00155; P97363 CHOYP_SPTC2.3.4 m.22359 sp SPTC2_MOUSE 65.51 490 167 2 52 539 57 546 0 672 SPTC2_MOUSE reviewed Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) Sptlc2 Lcb2 Mus musculus (Mouse) 560 ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] GO:0004758; GO:0005739; GO:0006686; GO:0016021; GO:0017059; GO:0030148; GO:0030170; GO:0046511; GO:0046512; GO:0046513; GO:1904504 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00155; P97363 CHOYP_SPTC2.4.4 m.66019 sp SPTC2_MOUSE 59.238 525 203 4 21 534 15 539 0 643 SPTC2_MOUSE reviewed Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) Sptlc2 Lcb2 Mus musculus (Mouse) 560 ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512] GO:0004758; GO:0005739; GO:0006686; GO:0016021; GO:0017059; GO:0030148; GO:0030170; GO:0046511; GO:0046512; GO:0046513; GO:1904504 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00155; P97390 CHOYP_VPS45.1.1 m.8023 sp VPS45_MOUSE 72.389 565 152 2 1 561 1 565 0 851 VPS45_MOUSE reviewed Vacuolar protein sorting-associated protein 45 (mVps45) Vps45 Vps45a Mus musculus (Mouse) 570 protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904] GO:0000139; GO:0006904; GO:0010008; GO:0015031; GO:0016021 0 0 0 PF00995; P97412 CHOYP_BRAFLDRAFT_126843.1.1 m.35469 sp LYST_MOUSE 39.832 1549 848 29 2192 3725 2286 3765 0 1065 LYST_MOUSE reviewed Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog) Lyst Bg Chs1 Mus musculus (Mouse) 3788 blood coagulation [GO:0007596]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; leukocyte chemotaxis [GO:0030595]; lysosome organization [GO:0007040]; mast cell secretory granule organization [GO:0033364]; melanosome organization [GO:0032438]; microtubule-based process [GO:0007017]; natural killer cell mediated cytotoxicity [GO:0042267]; neutrophil mediated immunity [GO:0002446]; phospholipid homeostasis [GO:0055091]; phospholipid metabolic process [GO:0006644]; pigmentation [GO:0043473]; pigment granule organization [GO:0048753]; positive regulation of natural killer cell activation [GO:0032816]; response to drug [GO:0042493]; secretion of lysosomal enzymes [GO:0033299]; T cell mediated immunity [GO:0002456] GO:0002446; GO:0002456; GO:0005829; GO:0006644; GO:0007017; GO:0007040; GO:0007596; GO:0015630; GO:0030595; GO:0032438; GO:0032510; GO:0032816; GO:0033299; GO:0033364; GO:0042267; GO:0042493; GO:0042742; GO:0042832; GO:0043473; GO:0048753; GO:0051607; GO:0055091 0 0 cd06071; PF02138;PF14844;PF00400; P97526 CHOYP_LOC100118811.1.1 m.57633 sp NF1_RAT 57.778 2925 1023 48 1 2818 1 2820 0 3225 NF1_RAT reviewed Neurofibromin (Neurofibromatosis-related protein NF-1) Nf1 Rattus norvegicus (Rat) 2820 actin cytoskeleton organization [GO:0030036]; adrenal gland development [GO:0030325]; artery morphogenesis [GO:0048844]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cell communication [GO:0007154]; cerebral cortex development [GO:0021987]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; forebrain astrocyte development [GO:0021897]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; liver development [GO:0001889]; MAPK cascade [GO:0000165]; metanephros development [GO:0001656]; myelination in peripheral nervous system [GO:0022011]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of transcription factor import into nucleus [GO:0042992]; osteoblast differentiation [GO:0001649]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling [GO:0014065]; pigmentation [GO:0043473]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of apoptotic process [GO:0043065]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron apoptotic process [GO:0043525]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of bone resorption [GO:0045124]; regulation of cell-matrix adhesion [GO:0001952]; regulation of glial cell differentiation [GO:0045685]; regulation of GTPase activity [GO:0043087]; regulation of neuron differentiation [GO:0045664]; response to hypoxia [GO:0001666]; Schwann cell development [GO:0014044]; smooth muscle tissue development [GO:0048745]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; visual learning [GO:0008542]; wound healing [GO:0042060] GO:0000165; GO:0001649; GO:0001656; GO:0001666; GO:0001889; GO:0001952; GO:0005096; GO:0005634; GO:0005730; GO:0005737; GO:0006469; GO:0007154; GO:0007265; GO:0007406; GO:0007420; GO:0007422; GO:0007507; GO:0008017; GO:0008429; GO:0008542; GO:0014044; GO:0014065; GO:0014069; GO:0016020; GO:0021510; GO:0021897; GO:0021987; GO:0022011; GO:0030036; GO:0030198; GO:0030199; GO:0030325; GO:0030424; GO:0030425; GO:0031210; GO:0031235; GO:0042060; GO:0042992; GO:0043005; GO:0043065; GO:0043087; GO:0043234; GO:0043407; GO:0043409; GO:0043473; GO:0043525; GO:0043547; GO:0045124; GO:0045545; GO:0045664; GO:0045685; GO:0045762; GO:0045765; GO:0046580; GO:0048147; GO:0048485; GO:0048593; GO:0048715; GO:0048745; GO:0048844; GO:0048853 0 0 0 PF13716;PF00616; P97739 CHOYP_CLSTN1.1.1 m.55324 sp ECE1_CAVPO 39.227 724 416 14 60 777 49 754 0 547 ECE1_CAVPO reviewed Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 Cavia porcellus (Guinea pig) 754 protein processing [GO:0016485] GO:0004222; GO:0005886; GO:0016021; GO:0016485; GO:0046872 0 0 cd08662; PF01431;PF05649; P97739 CHOYP_NEMVEDRAFT_V1G229362.1.1 m.60239 sp ECE1_CAVPO 38.41 742 433 14 59 794 31 754 0 545 ECE1_CAVPO reviewed Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 Cavia porcellus (Guinea pig) 754 protein processing [GO:0016485] GO:0004222; GO:0005886; GO:0016021; GO:0016485; GO:0046872 0 0 cd08662; PF01431;PF05649; P97798 CHOYP_NEO1.3.3 m.61836 sp NEO1_MOUSE 35.548 1505 841 36 31 1479 60 1491 0 780 NEO1_MOUSE reviewed Neogenin Neo1 Ngn Mus musculus (Mouse) 1493 "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; iron ion homeostasis [GO:0055072]; myoblast fusion [GO:0007520]; negative regulation of protein secretion [GO:0050709]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of transcription, DNA-templated [GO:0006355]" GO:0004872; GO:0005654; GO:0005794; GO:0005886; GO:0005887; GO:0006355; GO:0007155; GO:0007411; GO:0007520; GO:0030513; GO:0039706; GO:0045296; GO:0050709; GO:0051149; GO:0055072; GO:0070700; GO:0098797 0 0 0 PF00041;PF07679;PF13895;PF06583; P97879 CHOYP_GRIP1.1.1 m.12746 sp GRIP1_RAT 39.678 1056 521 23 36 1000 47 1077 0 676 GRIP1_RAT reviewed Glutamate receptor-interacting protein 1 (GRIP-1) (AMPA receptor-interacting protein GRIP1) Grip1 Rattus norvegicus (Rat) 1112 dendrite development [GO:0016358]; nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005102; GO:0005789; GO:0007399; GO:0014069; GO:0015031; GO:0016358; GO:0030054; GO:0043025; GO:0045211 0 0 0 PF00595; P98156 CHOYP_LOC100863386.1.1 m.37224 sp VLDLR_MOUSE 41.638 879 448 24 26 888 25 854 0 645 VLDLR_MOUSE reviewed Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) Vldlr Mus musculus (Mouse) 873 cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cerebral cortex development [GO:0021987]; cholesterol metabolic process [GO:0008203]; dendrite morphogenesis [GO:0048813]; glycoprotein transport [GO:0034436]; heart development [GO:0007507]; lipid transport [GO:0006869]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dendrite development [GO:1900006]; positive regulation of protein kinase activity [GO:0045860]; receptor-mediated endocytosis [GO:0006898]; reelin-mediated signaling pathway [GO:0038026]; response to drug [GO:0042493]; response to nutrient [GO:0007584]; ventral spinal cord development [GO:0021517]; very-low-density lipoprotein particle clearance [GO:0034447] GO:0000122; GO:0001948; GO:0005509; GO:0005615; GO:0005634; GO:0005905; GO:0006869; GO:0006898; GO:0007507; GO:0007584; GO:0008203; GO:0009986; GO:0016020; GO:0016021; GO:0021517; GO:0021987; GO:0030229; GO:0032869; GO:0034185; GO:0034189; GO:0034361; GO:0034436; GO:0034437; GO:0034447; GO:0038025; GO:0038026; GO:0042149; GO:0042493; GO:0043235; GO:0045177; GO:0045860; GO:0048306; GO:0048471; GO:0048813; GO:0071222; GO:0071347; GO:0071456; GO:1900006 0 0 0 PF07645;PF00057;PF00058; P98158 CHOYP_LRP2.6.7 m.41365 sp LRP2_RAT 42.468 4481 2352 85 22 4391 179 4544 0 3579 LRP2_RAT reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) 4660 aging [GO:0007568]; endosomal transport [GO:0016197]; hemoglobin import [GO:0020028]; hormone secretion [GO:0046879]; lipoprotein transport [GO:0042953]; negative regulation of endopeptidase activity [GO:0010951]; organ regeneration [GO:0031100]; receptor-mediated endocytosis [GO:0006898]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; transcytosis [GO:0045056]; vitamin metabolic process [GO:0006766] GO:0004872; GO:0005509; GO:0005615; GO:0005737; GO:0005768; GO:0005903; GO:0005905; GO:0006766; GO:0006898; GO:0007568; GO:0010165; GO:0010951; GO:0016020; GO:0016021; GO:0016197; GO:0016324; GO:0020028; GO:0030165; GO:0030492; GO:0031100; GO:0031526; GO:0032403; GO:0032526; GO:0033280; GO:0042493; GO:0042562; GO:0042953; GO:0043234; GO:0045056; GO:0045121; GO:0046879; GO:0050750 0 0 0 PF12662;PF07645;PF00057;PF00058; P98158 CHOYP_PHUM_PHUM470230.1.1 m.29432 sp LRP2_RAT 47.555 961 464 14 1 936 3019 3964 0 891 LRP2_RAT reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) 4660 aging [GO:0007568]; endosomal transport [GO:0016197]; hemoglobin import [GO:0020028]; hormone secretion [GO:0046879]; lipoprotein transport [GO:0042953]; negative regulation of endopeptidase activity [GO:0010951]; organ regeneration [GO:0031100]; receptor-mediated endocytosis [GO:0006898]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; transcytosis [GO:0045056]; vitamin metabolic process [GO:0006766] GO:0004872; GO:0005509; GO:0005615; GO:0005737; GO:0005768; GO:0005903; GO:0005905; GO:0006766; GO:0006898; GO:0007568; GO:0010165; GO:0010951; GO:0016020; GO:0016021; GO:0016197; GO:0016324; GO:0020028; GO:0030165; GO:0030492; GO:0031100; GO:0031526; GO:0032403; GO:0032526; GO:0033280; GO:0042493; GO:0042562; GO:0042953; GO:0043234; GO:0045056; GO:0045121; GO:0046879; GO:0050750 0 0 0 PF12662;PF07645;PF00057;PF00058; P98160 CHOYP_HSPG2.1.4 m.1494 sp PGBM_HUMAN 31.202 1939 1153 47 221 2049 2522 4389 0 893 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; P98160 CHOYP_HSPG2.1.4 m.1495 sp PGBM_HUMAN 43.409 1191 611 23 63 1228 273 1425 0 946 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; P98160 CHOYP_LOC754561.1.1 m.80 sp PGBM_HUMAN 36.023 2751 1519 64 972 3615 194 2810 0 1588 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; P98160 CHOYP_PHUM_PHUM066670.2.3 m.42178 sp PGBM_HUMAN 35.987 2751 1520 64 1007 3650 194 2810 0 1591 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; P98161 CHOYP_LOC100368847.1.1 m.36484 sp PKD1_HUMAN 24.235 3169 2077 97 675 3713 406 3380 0 740 PKD1_HUMAN reviewed Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein) PKD1 Homo sapiens (Human) 4303 anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-independent cell-matrix adhesion [GO:0007161]; calcium ion transmembrane transport [GO:0070588]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell cycle arrest [GO:0007050]; cell-matrix adhesion [GO:0007160]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of cell polarity [GO:0030010]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; JAK-STAT cascade [GO:0007259]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; neural tube development [GO:0021915]; nitrogen compound metabolic process [GO:0006807]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein export from nucleus [GO:0006611]; regulation of cell adhesion [GO:0030155]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; single organismal cell-cell adhesion [GO:0016337]; skin development [GO:0043588]; spinal cord development [GO:0021510] GO:0000139; GO:0001502; GO:0001701; GO:0001822; GO:0001889; GO:0001892; GO:0002133; GO:0005262; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005929; GO:0006611; GO:0006807; GO:0007050; GO:0007156; GO:0007160; GO:0007161; GO:0007204; GO:0007259; GO:0007507; GO:0009653; GO:0009986; GO:0016021; GO:0016323; GO:0016328; GO:0016337; GO:0018105; GO:0019901; GO:0019904; GO:0021510; GO:0021915; GO:0030010; GO:0030155; GO:0030246; GO:0030660; GO:0031512; GO:0031659; GO:0032092; GO:0034405; GO:0036303; GO:0042994; GO:0043588; GO:0044325; GO:0045944; GO:0048565; GO:0048754; GO:0048806; GO:0050982; GO:0051216; GO:0060170; GO:0060236; GO:0060428; GO:0060674; GO:0061136; GO:0070062; GO:0070588; GO:0072164; GO:0072177; GO:0072205; GO:0072218; GO:0072237; GO:0072287; GO:0072372 0 0 0 PF00059;PF13855;PF00801;PF08016;PF01477;PF02010;PF01822; P98161 CHOYP_PKD1.2.3 m.54715 sp PKD1_HUMAN 24.298 3169 2075 97 431 3469 406 3380 0 747 PKD1_HUMAN reviewed Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein) PKD1 Homo sapiens (Human) 4303 anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-independent cell-matrix adhesion [GO:0007161]; calcium ion transmembrane transport [GO:0070588]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell cycle arrest [GO:0007050]; cell-matrix adhesion [GO:0007160]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of cell polarity [GO:0030010]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; JAK-STAT cascade [GO:0007259]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; neural tube development [GO:0021915]; nitrogen compound metabolic process [GO:0006807]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein export from nucleus [GO:0006611]; regulation of cell adhesion [GO:0030155]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; single organismal cell-cell adhesion [GO:0016337]; skin development [GO:0043588]; spinal cord development [GO:0021510] GO:0000139; GO:0001502; GO:0001701; GO:0001822; GO:0001889; GO:0001892; GO:0002133; GO:0005262; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005929; GO:0006611; GO:0006807; GO:0007050; GO:0007156; GO:0007160; GO:0007161; GO:0007204; GO:0007259; GO:0007507; GO:0009653; GO:0009986; GO:0016021; GO:0016323; GO:0016328; GO:0016337; GO:0018105; GO:0019901; GO:0019904; GO:0021510; GO:0021915; GO:0030010; GO:0030155; GO:0030246; GO:0030660; GO:0031512; GO:0031659; GO:0032092; GO:0034405; GO:0036303; GO:0042994; GO:0043588; GO:0044325; GO:0045944; GO:0048565; GO:0048754; GO:0048806; GO:0050982; GO:0051216; GO:0060170; GO:0060236; GO:0060428; GO:0060674; GO:0061136; GO:0070062; GO:0070588; GO:0072164; GO:0072177; GO:0072205; GO:0072218; GO:0072237; GO:0072287; GO:0072372 0 0 0 PF00059;PF13855;PF00801;PF08016;PF01477;PF02010;PF01822; P98194 CHOYP_SPCA.1.1 m.6746 sp AT2C1_HUMAN 65.345 883 305 1 30 912 26 907 0 1169 AT2C1_HUMAN reviewed Calcium-transporting ATPase type 2C member 1 (ATPase 2C1) (EC 3.6.3.8) (ATP-dependent Ca(2+) pump PMR1) ATP2C1 KIAA1347 PMR1L HUSSY-28 Homo sapiens (Human) 919 actin cytoskeleton reorganization [GO:0031532]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; cellular manganese ion homeostasis [GO:0030026]; epidermis development [GO:0008544]; Golgi calcium ion homeostasis [GO:0032468]; Golgi calcium ion transport [GO:0032472]; ion transmembrane transport [GO:0034220]; manganese ion transport [GO:0006828]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0000139; GO:0004871; GO:0005388; GO:0005509; GO:0005524; GO:0005794; GO:0005802; GO:0005887; GO:0006816; GO:0006828; GO:0006874; GO:0008544; GO:0015410; GO:0016020; GO:0016021; GO:0016339; GO:0030026; GO:0030145; GO:0031532; GO:0032468; GO:0032472; GO:0034220; GO:0043123; GO:0046872 0 0 0 PF00689;PF00690;PF00122; P98199 CHOYP_ATP8B2.1.3 m.25610 sp AT8B2_MOUSE 55.178 1207 494 12 4 1189 20 1200 0 1337 AT8B2_MOUSE reviewed Phospholipid-transporting ATPase ID (EC 3.6.3.1) (ATPase class I type 8B member 2) (P4-ATPase flippase complex alpha subunit ATP8B2) Atp8b2 Mus musculus (Mouse) 1209 Golgi organization [GO:0007030] GO:0000287; GO:0004012; GO:0005524; GO:0005789; GO:0005794; GO:0005886; GO:0007030; GO:0016021 0 0 0 PF00122;PF16212;PF16209; Q00174 CHOYP_LOC100875585.1.1 m.8714 sp LAMA_DROME 39.192 3294 1832 59 11 3224 8 3210 0 2350 LAMA_DROME reviewed Laminin subunit alpha (Laminin A chain) LanA lamA CG10236 Drosophila melanogaster (Fruit fly) 3712 "axon guidance [GO:0007411]; brain morphogenesis [GO:0048854]; cell adhesion mediated by integrin [GO:0033627]; dorsal trunk growth, open tracheal system [GO:0035001]; female meiosis chromosome segregation [GO:0016321]; heart development [GO:0007507]; imaginal disc-derived wing morphogenesis [GO:0007476]; inter-male aggressive behavior [GO:0002121]; locomotion involved in locomotory behavior [GO:0031987]; melanotic encapsulation of foreign target [GO:0035011]; mesoderm development [GO:0007498]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]; regulation of glucose metabolic process [GO:0010906]; startle response [GO:0001964]; substrate adhesion-dependent cell spreading [GO:0034446]" GO:0001964; GO:0002121; GO:0005604; GO:0005605; GO:0007411; GO:0007476; GO:0007498; GO:0007507; GO:0008021; GO:0010906; GO:0016321; GO:0030054; GO:0030155; GO:0030334; GO:0030424; GO:0031987; GO:0033627; GO:0034446; GO:0035001; GO:0035011; GO:0036062; GO:0045886; GO:0045995; GO:0048854 0 0 0 PF00052;PF00053;PF00054;PF02210;PF06008;PF06009;PF00055; Q00341 CHOYP_VIGLN.1.2 m.34766 sp VIGLN_HUMAN 56.778 1254 501 14 13 1242 32 1268 0 1410 VIGLN_HUMAN reviewed Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) HDLBP HBP VGL Homo sapiens (Human) 1268 cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869] GO:0005634; GO:0005737; GO:0005886; GO:0005913; GO:0006869; GO:0008203; GO:0008289; GO:0034364; GO:0044822; GO:0098641 0 0 0 PF00013; Q00536 CHOYP_LOC101068677.1.1 m.30685 sp CDK16_HUMAN 67.955 440 116 3 91 527 69 486 0 612 CDK16_HUMAN reviewed Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) CDK16 PCTAIRE1 PCTK1 Homo sapiens (Human) 496 exocytosis [GO:0006887]; growth hormone secretion [GO:0030252]; neuron projection development [GO:0031175]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; spermatogenesis [GO:0007283] GO:0004674; GO:0004693; GO:0005524; GO:0005737; GO:0005886; GO:0006468; GO:0006887; GO:0007283; GO:0008021; GO:0015630; GO:0030054; GO:0030252; GO:0031175; GO:0031234; GO:0043005; GO:0061178 0 0 0 PF00069; Q00963 CHOYP_LOC100114310.1.2 m.39844 sp SPTCB_DROME 64.966 745 255 3 1 742 429 1170 0 974 SPTCB_DROME reviewed Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) 2291 actin filament capping [GO:0051693]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; fusome organization [GO:0045478]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; photoreceptor cell axon guidance [GO:0072499]; plasma membrane organization [GO:0007009]; regulation of synapse organization [GO:0050807]; spectrosome organization [GO:0030721] GO:0003779; GO:0005200; GO:0005546; GO:0005811; GO:0005886; GO:0007009; GO:0007026; GO:0007274; GO:0007399; GO:0007409; GO:0007411; GO:0008017; GO:0008091; GO:0008092; GO:0016199; GO:0016327; GO:0016328; GO:0030424; GO:0030506; GO:0030721; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048790; GO:0050807; GO:0051693; GO:0072499 0 0 0 PF00307;PF00435; Q00963 CHOYP_LOC100114310.2.2 m.64227 sp SPTCB_DROME 64.785 2090 720 7 11 2088 8 2093 0 2758 SPTCB_DROME reviewed Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) 2291 actin filament capping [GO:0051693]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; fusome organization [GO:0045478]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; photoreceptor cell axon guidance [GO:0072499]; plasma membrane organization [GO:0007009]; regulation of synapse organization [GO:0050807]; spectrosome organization [GO:0030721] GO:0003779; GO:0005200; GO:0005546; GO:0005811; GO:0005886; GO:0007009; GO:0007026; GO:0007274; GO:0007399; GO:0007409; GO:0007411; GO:0008017; GO:0008091; GO:0008092; GO:0016199; GO:0016327; GO:0016328; GO:0030424; GO:0030506; GO:0030721; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048790; GO:0050807; GO:0051693; GO:0072499 0 0 0 PF00307;PF00435; Q00963 CHOYP_LOC100377364.1.2 m.4828 sp SPTCB_DROME 29.329 2131 1371 32 9 2093 36 2077 0 821 SPTCB_DROME reviewed Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) 2291 actin filament capping [GO:0051693]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; fusome organization [GO:0045478]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; photoreceptor cell axon guidance [GO:0072499]; plasma membrane organization [GO:0007009]; regulation of synapse organization [GO:0050807]; spectrosome organization [GO:0030721] GO:0003779; GO:0005200; GO:0005546; GO:0005811; GO:0005886; GO:0007009; GO:0007026; GO:0007274; GO:0007399; GO:0007409; GO:0007411; GO:0008017; GO:0008091; GO:0008092; GO:0016199; GO:0016327; GO:0016328; GO:0030424; GO:0030506; GO:0030721; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048790; GO:0050807; GO:0051693; GO:0072499 0 0 0 PF00307;PF00435; Q00963 CHOYP_LOC100743601.1.1 m.37797 sp SPTCB_DROME 54.014 1146 503 7 1 1145 1169 2291 0 1202 SPTCB_DROME reviewed Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) 2291 actin filament capping [GO:0051693]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; fusome organization [GO:0045478]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; photoreceptor cell axon guidance [GO:0072499]; plasma membrane organization [GO:0007009]; regulation of synapse organization [GO:0050807]; spectrosome organization [GO:0030721] GO:0003779; GO:0005200; GO:0005546; GO:0005811; GO:0005886; GO:0007009; GO:0007026; GO:0007274; GO:0007399; GO:0007409; GO:0007411; GO:0008017; GO:0008091; GO:0008092; GO:0016199; GO:0016327; GO:0016328; GO:0030424; GO:0030506; GO:0030721; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048790; GO:0050807; GO:0051693; GO:0072499 0 0 0 PF00307;PF00435; Q00963 CHOYP_SPTCB.1.1 m.37786 sp SPTCB_DROME 69.61 1178 344 5 11 1177 8 1182 0 1680 SPTCB_DROME reviewed Spectrin beta chain beta-Spec Spec-b CG5870 Drosophila melanogaster (Fruit fly) 2291 actin filament capping [GO:0051693]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; axonogenesis [GO:0007409]; fusome organization [GO:0045478]; long-term strengthening of neuromuscular junction [GO:0042062]; maintenance of presynaptic active zone structure [GO:0048790]; negative regulation of microtubule depolymerization [GO:0007026]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; photoreceptor cell axon guidance [GO:0072499]; plasma membrane organization [GO:0007009]; regulation of synapse organization [GO:0050807]; spectrosome organization [GO:0030721] GO:0003779; GO:0005200; GO:0005546; GO:0005811; GO:0005886; GO:0007009; GO:0007026; GO:0007274; GO:0007399; GO:0007409; GO:0007411; GO:0008017; GO:0008091; GO:0008092; GO:0016199; GO:0016327; GO:0016328; GO:0030424; GO:0030506; GO:0030721; GO:0031594; GO:0042062; GO:0045169; GO:0045170; GO:0045478; GO:0048790; GO:0050807; GO:0051693; GO:0072499 0 0 0 PF00307;PF00435; Q01063 CHOYP_LOC100874620.1.1 m.23782 sp PDE4D_MOUSE 64.148 622 201 8 47 654 73 686 0 792 PDE4D_MOUSE reviewed "cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3)" Pde4d Mus musculus (Mouse) 747 aging [GO:0007568]; cAMP catabolic process [GO:0006198]; cellular response to cAMP [GO:0071320]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to lipopolysaccharide [GO:0071222]; establishment of endothelial barrier [GO:0061028]; leukocyte migration [GO:0050900]; multicellular organism growth [GO:0035264]; negative regulation of heart contraction [GO:0045822]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of relaxation of cardiac muscle [GO:1901898]; neutrophil chemotaxis [GO:0030593]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-5 production [GO:0032754]; regulation of cAMP metabolic process [GO:0030814]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; smooth muscle contraction [GO:0006939]; T cell receptor signaling pathway [GO:0050852] GO:0002027; GO:0004115; GO:0005813; GO:0005829; GO:0006198; GO:0006939; GO:0007568; GO:0008144; GO:0010880; GO:0016324; GO:0030552; GO:0030593; GO:0030814; GO:0032729; GO:0032743; GO:0032754; GO:0033137; GO:0034704; GO:0035264; GO:0044325; GO:0045822; GO:0046872; GO:0050852; GO:0050900; GO:0051117; GO:0060314; GO:0061028; GO:0071222; GO:0071320; GO:0071872; GO:0086004; GO:1901844; GO:1901898 "PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." 0 0 PF00233; Q01082 CHOYP_LOC100114310.1.2 m.39843 sp SPTB2_HUMAN 49.79 1191 553 11 22 1207 1172 2322 0 1111 SPTB2_HUMAN reviewed "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)" SPTBN1 SPTB2 Homo sapiens (Human) 2364 actin filament capping [GO:0051693]; axon guidance [GO:0007411]; common-partner SMAD protein phosphorylation [GO:0007182]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi to plasma membrane protein transport [GO:0043001]; MAPK cascade [GO:0000165]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 secretion [GO:1900042]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein targeting to plasma membrane [GO:0072661]; regulation of protein localization to plasma membrane [GO:1903076]; SMAD protein import into nucleus [GO:0007184] GO:0000165; GO:0000281; GO:0003779; GO:0005088; GO:0005200; GO:0005543; GO:0005730; GO:0005737; GO:0005829; GO:0005913; GO:0006888; GO:0007009; GO:0007182; GO:0007184; GO:0007411; GO:0008091; GO:0014731; GO:0030506; GO:0030673; GO:0031430; GO:0032437; GO:0043001; GO:0044822; GO:0051020; GO:0051693; GO:0070062; GO:0071709; GO:0072661; GO:0098641; GO:1900042; GO:1903076; GO:1903078 0 0 0 PF00307;PF00435; Q01082 CHOYP_LOC100114310.1.2 m.39845 sp SPTB2_HUMAN 77.435 421 94 1 3 423 13 432 0 687 SPTB2_HUMAN reviewed "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)" SPTBN1 SPTB2 Homo sapiens (Human) 2364 actin filament capping [GO:0051693]; axon guidance [GO:0007411]; common-partner SMAD protein phosphorylation [GO:0007182]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi to plasma membrane protein transport [GO:0043001]; MAPK cascade [GO:0000165]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 secretion [GO:1900042]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein targeting to plasma membrane [GO:0072661]; regulation of protein localization to plasma membrane [GO:1903076]; SMAD protein import into nucleus [GO:0007184] GO:0000165; GO:0000281; GO:0003779; GO:0005088; GO:0005200; GO:0005543; GO:0005730; GO:0005737; GO:0005829; GO:0005913; GO:0006888; GO:0007009; GO:0007182; GO:0007184; GO:0007411; GO:0008091; GO:0014731; GO:0030506; GO:0030673; GO:0031430; GO:0032437; GO:0043001; GO:0044822; GO:0051020; GO:0051693; GO:0070062; GO:0071709; GO:0072661; GO:0098641; GO:1900042; GO:1903076; GO:1903078 0 0 0 PF00307;PF00435; Q01237 CHOYP_BRAFLDRAFT_57278.1.1 m.24893 sp HMDH_MOUSE 54.392 888 361 13 1 857 1 875 0 964 HMDH_MOUSE reviewed 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) Hmgcr Mus musculus (Mouse) 887 aging [GO:0007568]; cholesterol biosynthetic process [GO:0006695]; coenzyme A metabolic process [GO:0015936]; isoprenoid biosynthetic process [GO:0008299]; myoblast differentiation [GO:0045445]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; negative regulation of vasodilation [GO:0045908]; negative regulation of wound healing [GO:0061045]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein tetramerization [GO:0051262]; response to ethanol [GO:0045471]; response to nutrient [GO:0007584]; ubiquinone metabolic process [GO:0006743]; visual learning [GO:0008542] GO:0004420; GO:0005778; GO:0005783; GO:0005789; GO:0006695; GO:0006743; GO:0007568; GO:0007584; GO:0008299; GO:0008542; GO:0010664; GO:0010666; GO:0015936; GO:0016021; GO:0032874; GO:0042282; GO:0043407; GO:0045445; GO:0045471; GO:0045908; GO:0048643; GO:0048661; GO:0050662; GO:0051262; GO:0061045; GO:0061179; GO:0070374; GO:0070402 PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3. 0 cd00643; PF00368;PF12349; Q01241 CHOYP_NF70.4.4 m.63507 sp NF70_DORPE 53.333 630 273 6 7 632 2 614 0 652 NF70_DORPE reviewed 70 kDa neurofilament protein (NF70) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 615 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q01433 CHOYP_AMPD2.1.2 m.1295 sp AMPD2_HUMAN 57.828 792 289 11 18 791 94 858 0 905 AMPD2_HUMAN reviewed AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) AMPD2 Homo sapiens (Human) 879 AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cyclic purine nucleotide metabolic process [GO:0052652]; energy homeostasis [GO:0097009]; GTP metabolic process [GO:0046039]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]; purine-containing compound salvage [GO:0043101] GO:0003876; GO:0005829; GO:0006188; GO:0032264; GO:0043101; GO:0046033; GO:0046034; GO:0046039; GO:0046872; GO:0052652; GO:0097009 PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. 0 cd01319; PF00962; Q01433 CHOYP_AMPD2.2.2 m.1706 sp AMPD2_HUMAN 55.934 792 283 12 18 770 94 858 0 863 AMPD2_HUMAN reviewed AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) AMPD2 Homo sapiens (Human) 879 AMP metabolic process [GO:0046033]; ATP metabolic process [GO:0046034]; cyclic purine nucleotide metabolic process [GO:0052652]; energy homeostasis [GO:0097009]; GTP metabolic process [GO:0046039]; IMP biosynthetic process [GO:0006188]; IMP salvage [GO:0032264]; purine-containing compound salvage [GO:0043101] GO:0003876; GO:0005829; GO:0006188; GO:0032264; GO:0043101; GO:0046033; GO:0046034; GO:0046039; GO:0046872; GO:0052652; GO:0097009 PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. 0 cd01319; PF00962; Q01484 CHOYP_ANK.1.3 m.12678 sp ANK2_HUMAN 64.491 904 310 6 13 909 17 916 0 1184 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK.3.3 m.46523 sp ANK2_HUMAN 64.491 904 310 6 13 909 17 916 0 1184 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK2.1.8 m.2662 sp ANK2_HUMAN 67.497 843 268 4 13 854 17 854 0 1182 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK3.1.9 m.2668 sp ANK2_HUMAN 64.491 904 310 6 13 909 17 916 0 1181 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK3.3.9 m.6798 sp ANK2_HUMAN 64.151 901 308 5 29 915 17 916 0 1175 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK3.5.9 m.27762 sp ANK2_HUMAN 67.143 840 266 3 13 844 17 854 0 1174 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK3.6.9 m.40966 sp ANK2_HUMAN 67.143 840 266 3 13 844 17 854 0 1172 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK3.7.9 m.43272 sp ANK2_HUMAN 67.497 843 268 4 13 854 17 854 0 1210 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_ANK3.9.9 m.66493 sp ANK2_HUMAN 67.497 843 268 4 13 854 17 854 0 1183 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_LOC100907797.4.4 m.66838 sp ANK2_HUMAN 59.426 1464 503 16 5 1412 25 1453 0 1734 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_contig_044077 m.50894 sp ANK2_HUMAN 67.904 835 262 4 5 838 25 854 0 1182 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01484 CHOYP_contig_044078 m.50900 sp ANK2_HUMAN 67.668 832 259 3 5 828 25 854 0 1174 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01780 CHOYP_EXOSC10.1.1 m.39774 sp EXOSX_HUMAN 41.801 866 444 17 14 825 26 885 0 613 EXOSX_HUMAN reviewed Exosome component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2) EXOSC10 PMSCL PMSCL2 RRP6 Homo sapiens (Human) 885 "CUT catabolic process [GO:0071034]; dosage compensation by inactivation of X chromosome [GO:0009048]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear retention of unspliced pre-mRNA at the site of transcription [GO:0071048]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]" GO:0000166; GO:0000175; GO:0000176; GO:0000178; GO:0000184; GO:0000460; GO:0000956; GO:0004532; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0009048; GO:0016020; GO:0035327; GO:0044822; GO:0071028; GO:0071034; GO:0071035; GO:0071044; GO:0071048 0 0 0 PF01612;PF00570;PF08066; Q02280 CHOYP_KCNAE.1.1 m.32150 sp KCNAE_DROME 57.785 957 355 13 1 930 1 935 0 1129 KCNAE_DROME reviewed Potassium voltage-gated channel protein eag (Ether-a-go-go protein) eag CG10952 Drosophila melanogaster (Fruit fly) 1174 behavioral response to ether [GO:0048150]; courtship behavior [GO:0007619]; flight behavior [GO:0007629]; learning [GO:0007612]; learning or memory [GO:0007611]; perineurial glial growth [GO:0042066]; potassium ion transport [GO:0006813]; protein oligomerization [GO:0051259]; regulation of heart contraction [GO:0008016]; regulation of membrane potential [GO:0042391]; sensory perception of smell [GO:0007608] GO:0000155; GO:0005249; GO:0005622; GO:0005886; GO:0006813; GO:0007608; GO:0007611; GO:0007612; GO:0007619; GO:0007629; GO:0008016; GO:0008076; GO:0022843; GO:0042066; GO:0042391; GO:0048150; GO:0051259 0 0 0 PF00027;PF00520;PF13426; Q02440 CHOYP_MYO5A.4.4 m.60049 sp MYO5A_CHICK 56.84 519 209 7 531 1045 1322 1829 0 588 MYO5A_CHICK reviewed "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain p190) (Myosin-V)" MYO5A Gallus gallus (Chicken) 1829 cellular response to insulin stimulus [GO:0032869]; protein localization to plasma membrane [GO:0072659]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0000146; GO:0005516; GO:0005524; GO:0016192; GO:0016459; GO:0031941; GO:0032593; GO:0032869; GO:0060001; GO:0072659 0 0 0 PF01843;PF00612;PF00063; Q02880 CHOYP_TOP2A.1.1 m.63047 sp TOP2B_HUMAN 70.568 1162 340 2 23 1184 47 1206 0 1763 TOP2B_HUMAN reviewed "DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)" TOP2B Homo sapiens (Human) 1626 axonogenesis [GO:0007409]; DNA topological change [GO:0006265]; DNA unwinding involved in DNA replication [GO:0006268]; forebrain development [GO:0030900]; mitotic DNA integrity checkpoint [GO:0044774]; mitotic recombination [GO:0006312]; neuron migration [GO:0001764]; protein sumoylation [GO:0016925]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819] GO:0000712; GO:0000819; GO:0001764; GO:0003682; GO:0003918; GO:0005080; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006265; GO:0006268; GO:0006312; GO:0007409; GO:0008022; GO:0008301; GO:0009330; GO:0016925; GO:0019899; GO:0030900; GO:0042826; GO:0044774; GO:0046872; GO:0046982 0 0 0 PF00204;PF00521;PF08070;PF02518;PF01751;PF16898; Q03042 CHOYP_LOC100533328.1.1 m.7560 sp KGP1_DROME 62.303 634 224 6 157 782 142 768 0 832 KGP1_DROME reviewed "cGMP-dependent protein kinase, isozyme 1 (cGK) (EC 2.7.11.12)" Pkg21D DG1 CG3324 Drosophila melanogaster (Fruit fly) 768 larval somatic muscle development [GO:0007526]; protein phosphorylation [GO:0006468]; regulation of glucose metabolic process [GO:0010906] GO:0004674; GO:0004692; GO:0005524; GO:0005737; GO:0006468; GO:0007526; GO:0010906; GO:0030553 0 0 0 PF00027;PF00069; Q03333 CHOYP_PC2.1.2 m.34945 sp NEC2_PIG 60.417 624 213 7 17 639 14 604 0 760 NEC2_PIG reviewed Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) PCSK2 PC2 Sus scrofa (Pig) 638 protein processing [GO:0016485] GO:0004252; GO:0005615; GO:0016485; GO:0030133 0 0 0 PF01483;PF00082;PF16470; Q03333 CHOYP_PC2.2.2 m.62342 sp NEC2_PIG 60.417 624 213 7 17 639 14 604 0 760 NEC2_PIG reviewed Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) PCSK2 PC2 Sus scrofa (Pig) 638 protein processing [GO:0016485] GO:0004252; GO:0005615; GO:0016485; GO:0030133 0 0 0 PF01483;PF00082;PF16470; Q03460 CHOYP_BRAFLDRAFT_129259.1.1 m.9267 sp GLSN_MEDSA 54.302 2092 899 26 11 2055 78 2159 0 2257 GLSN_MEDSA reviewed "Glutamate synthase [NADH], amyloplastic (EC 1.4.1.14) (NADH-GOGAT)" 0 Medicago sativa (Alfalfa) 2194 cellular amino acid biosynthetic process [GO:0008652]; glutamine metabolic process [GO:0006541]; L-glutamate biosynthetic process [GO:0097054] GO:0005506; GO:0006541; GO:0008652; GO:0009501; GO:0010181; GO:0016040; GO:0050660; GO:0051538; GO:0097054 PATHWAY: Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.; PATHWAY: Energy metabolism; nitrogen metabolism. 0 cd02808; PF14691;PF00310;PF04898;PF01645;PF01493;PF07992; Q03468 CHOYP_ERCC6.1.1 m.13619 sp ERCC6_HUMAN 50.857 1109 471 23 359 1421 412 1492 0 1023 ERCC6_HUMAN reviewed DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB) ERCC6 CSB Homo sapiens (Human) 1493 "activation of JNKK activity [GO:0007256]; activation of JUN kinase activity [GO:0007257]; base-excision repair [GO:0006284]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; multicellular organism growth [GO:0035264]; photoreceptor cell maintenance [GO:0045494]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of gene expression, epigenetic [GO:0045815]; pyrimidine dimer repair [GO:0006290]; regulation of DNA-templated transcription, elongation [GO:0032784]; response to gamma radiation [GO:0010332]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303]; response to toxic substance [GO:0009636]; response to UV [GO:0009411]; response to UV-B [GO:0010224]; response to X-ray [GO:0010165]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000303; GO:0003677; GO:0003682; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006283; GO:0006284; GO:0006290; GO:0006362; GO:0006366; GO:0006979; GO:0007256; GO:0007257; GO:0008022; GO:0008023; GO:0008094; GO:0008630; GO:0009411; GO:0009636; GO:0010165; GO:0010224; GO:0010332; GO:0030296; GO:0032403; GO:0032784; GO:0032786; GO:0035264; GO:0045494; GO:0045815; GO:0047485 0 0 0 PF00271;PF00176; Q04336 CHOYP_LOC100636110.2.2 m.56309 sp YM54_YEAST 49.016 965 421 23 2 921 11 949 0 877 YM54_YEAST reviewed Uncharacterized protein YMR196W YMR196W YM9646.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1088 oligosaccharide metabolic process [GO:0009311]; protein N-linked glycosylation [GO:0006487] GO:0004573; GO:0006487; GO:0009311 0 0 0 0 Q04446 CHOYP_LOC100376863.1.1 m.65235 sp GLGB_HUMAN 67.407 675 218 2 6 680 27 699 0 983 GLGB_HUMAN reviewed "1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)" GBE1 Homo sapiens (Human) 702 generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977] GO:0003844; GO:0004553; GO:0005829; GO:0005977; GO:0005978; GO:0006091; GO:0043169; GO:0070062 PATHWAY: Glycan biosynthesis; glycogen biosynthesis. 0 0 PF00128;PF02806;PF02922; Q04678 CHOYP_SSRP1.1.1 m.19377 sp SSRP1_CHICK 57.031 640 250 8 1 635 1 620 0 731 SSRP1_CHICK reviewed FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (T160) SSRP1 CIIDBP RCJMB04_4n20 Gallus gallus (Chicken) 706 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005694; GO:0005730; GO:0006260; GO:0006281; GO:0006351; GO:0006355 0 0 0 PF00505;PF08512;PF03531; Q04721 CHOYP_LOC100375467.1.1 m.42789 sp NOTC2_HUMAN 38.618 984 568 21 3 968 173 1138 0 645 NOTC2_HUMAN reviewed Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] NOTCH2 Homo sapiens (Human) 2471 "apoptotic process [GO:0006915]; atrial septum morphogenesis [GO:0060413]; bone remodeling [GO:0046849]; cell cycle arrest [GO:0007050]; cell fate determination [GO:0001709]; cell growth [GO:0016049]; hemopoiesis [GO:0030097]; marginal zone B cell differentiation [GO:0002315]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; nervous system development [GO:0007399]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; organ morphogenesis [GO:0009887]; positive regulation of Ras protein signal transduction [GO:0046579]; pulmonary valve morphogenesis [GO:0003184]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; stem cell population maintenance [GO:0019827]; tissue regeneration [GO:0042246]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000139; GO:0001709; GO:0002315; GO:0003184; GO:0004872; GO:0005509; GO:0005576; GO:0005634; GO:0005654; GO:0005789; GO:0005886; GO:0005887; GO:0006355; GO:0006367; GO:0006915; GO:0007050; GO:0007219; GO:0007275; GO:0007399; GO:0008285; GO:0009887; GO:0009986; GO:0016020; GO:0016049; GO:0019827; GO:0030097; GO:0038049; GO:0042246; GO:0043066; GO:0043235; GO:0046579; GO:0046849; GO:0050793; GO:0060413; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; Q04799 CHOYP_FMO5.4.6 m.26322 sp FMO5_RABIT 53.184 534 244 4 5 536 4 533 0 579 FMO5_RABIT reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (FMO 1C1) (FMO form 3) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Oryctolagus cuniculus (Rabbit) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; Q04859 CHOYP_LOC100367705.1.1 m.9297 sp MAK_MOUSE 48.195 637 253 12 1 579 1 618 0 562 MAK_MOUSE reviewed Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell-associated kinase) (Protein kinase RCK) Mak Rck Mus musculus (Mouse) 622 "negative regulation of nonmotile primary cilium assembly [GO:1902856]; photoreceptor cell maintenance [GO:0045494]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001750; GO:0001917; GO:0003713; GO:0004672; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005930; GO:0006351; GO:0006355; GO:0006468; GO:0030496; GO:0031514; GO:0032391; GO:0045494; GO:0046777; GO:0072686; GO:0097542; GO:1902856 0 0 0 PF00069; Q05086 CHOYP_EF2.4.5 m.30185 sp UBE3A_HUMAN 48.465 912 373 14 33 910 24 872 0 826 UBE3A_HUMAN reviewed Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54) UBE3A E6AP EPVE6AP HPVE6A Homo sapiens (Human) 875 androgen receptor signaling pathway [GO:0030521]; brain development [GO:0007420]; ovarian follicle development [GO:0001541]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; prostate gland growth [GO:0060736]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000058]; sperm entry [GO:0035037]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032] GO:0000502; GO:0001541; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006511; GO:0007420; GO:0014068; GO:0016032; GO:0016874; GO:0030521; GO:0031398; GO:0035037; GO:0042752; GO:0045944; GO:0046872; GO:0051865; GO:0060736; GO:0061630; GO:0070936; GO:2000058 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF16558;PF00632; Q05397 CHOYP_LOC100876637.1.2 m.26061 sp FAK1_HUMAN 52.891 709 299 11 129 833 49 726 0 776 FAK1_HUMAN reviewed Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) PTK2 FAK FAK1 Homo sapiens (Human) 1052 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell motility [GO:0048870]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; central nervous system neuron axonogenesis [GO:0021955]; embryo development [GO:0009790]; endothelial cell migration [GO:0043542]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of cell polarity [GO:0030010]; establishment of nucleus localization [GO:0040023]; extracellular matrix organization [GO:0030198]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway [GO:0060396]; heart morphogenesis [GO:0003007]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; MAPK cascade [GO:0000165]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of organ growth [GO:0046621]; negative regulation of synapse assembly [GO:0051964]; netrin-activated signaling pathway [GO:0038007]; neuron migration [GO:0001764]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; placenta development [GO:0001890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of endothelial cell migration [GO:0010594]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570] GO:0000165; GO:0000226; GO:0001525; GO:0001570; GO:0001725; GO:0001764; GO:0001890; GO:0001932; GO:0001934; GO:0003007; GO:0003779; GO:0004672; GO:0004713; GO:0004715; GO:0004871; GO:0005088; GO:0005102; GO:0005524; GO:0005634; GO:0005737; GO:0005815; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0005938; GO:0006921; GO:0007172; GO:0007173; GO:0007179; GO:0007229; GO:0007411; GO:0008284; GO:0008360; GO:0008432; GO:0009790; GO:0010594; GO:0010632; GO:0014068; GO:0016324; GO:0018108; GO:0019901; GO:0021955; GO:0022408; GO:0030010; GO:0030027; GO:0030198; GO:0030335; GO:0031234; GO:0033628; GO:0038007; GO:0038083; GO:0038096; GO:0040023; GO:0042127; GO:0042169; GO:0043066; GO:0043087; GO:0043542; GO:0043552; GO:0045087; GO:0045667; GO:0045860; GO:0046621; GO:0046777; GO:0048010; GO:0048013; GO:0048870; GO:0050771; GO:0051493; GO:0051893; GO:0051897; GO:0051964; GO:0060396; GO:1900024; GO:2000060; GO:2000811 0 0 0 PF00373;PF03623;PF07714; Q05397 CHOYP_LOC100876637.2.2 m.66856 sp FAK1_HUMAN 54.148 687 296 10 129 805 49 726 0 786 FAK1_HUMAN reviewed Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) PTK2 FAK FAK1 Homo sapiens (Human) 1052 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell motility [GO:0048870]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; central nervous system neuron axonogenesis [GO:0021955]; embryo development [GO:0009790]; endothelial cell migration [GO:0043542]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of cell polarity [GO:0030010]; establishment of nucleus localization [GO:0040023]; extracellular matrix organization [GO:0030198]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway [GO:0060396]; heart morphogenesis [GO:0003007]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; MAPK cascade [GO:0000165]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of organ growth [GO:0046621]; negative regulation of synapse assembly [GO:0051964]; netrin-activated signaling pathway [GO:0038007]; neuron migration [GO:0001764]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; placenta development [GO:0001890]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of endothelial cell migration [GO:0010594]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570] GO:0000165; GO:0000226; GO:0001525; GO:0001570; GO:0001725; GO:0001764; GO:0001890; GO:0001932; GO:0001934; GO:0003007; GO:0003779; GO:0004672; GO:0004713; GO:0004715; GO:0004871; GO:0005088; GO:0005102; GO:0005524; GO:0005634; GO:0005737; GO:0005815; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0005938; GO:0006921; GO:0007172; GO:0007173; GO:0007179; GO:0007229; GO:0007411; GO:0008284; GO:0008360; GO:0008432; GO:0009790; GO:0010594; GO:0010632; GO:0014068; GO:0016324; GO:0018108; GO:0019901; GO:0021955; GO:0022408; GO:0030010; GO:0030027; GO:0030198; GO:0030335; GO:0031234; GO:0033628; GO:0038007; GO:0038083; GO:0038096; GO:0040023; GO:0042127; GO:0042169; GO:0043066; GO:0043087; GO:0043542; GO:0043552; GO:0045087; GO:0045667; GO:0045860; GO:0046621; GO:0046777; GO:0048010; GO:0048013; GO:0048870; GO:0050771; GO:0051493; GO:0051893; GO:0051897; GO:0051964; GO:0060396; GO:1900024; GO:2000060; GO:2000811 0 0 0 PF00373;PF03623;PF07714; Q05655 CHOYP_LOC100370583.1.1 m.56859 sp KPCD_HUMAN 53.21 701 284 8 6 694 4 672 0 766 KPCD_HUMAN reviewed Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)] PRKCD Homo sapiens (Human) 676 activation of phospholipase C activity [GO:0007202]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; B cell proliferation [GO:0042100]; cell chemotaxis [GO:0060326]; cell cycle [GO:0007049]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cellular response to angiotensin [GO:1904385]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hydroperoxide [GO:0071447]; cellular senescence [GO:0090398]; defense response to bacterium [GO:0042742]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; histone phosphorylation [GO:0016572]; immunoglobulin mediated immune response [GO:0016064]; interferon-gamma-mediated signaling pathway [GO:0060333]; interleukin-10 production [GO:0032613]; interleukin-12 production [GO:0032615]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein binding [GO:0032091]; neutrophil activation [GO:0042119]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; platelet activation [GO:0030168]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of glucosylceramide catabolic process [GO:2000753]; positive regulation of phospholipid scramblase activity [GO:1900163]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of response to DNA damage stimulus [GO:2001022]; positive regulation of sphingomyelin catabolic process [GO:2000755]; positive regulation of superoxide anion generation [GO:0032930]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of mRNA stability [GO:0043488]; regulation of receptor activity [GO:0010469]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; termination of signal transduction [GO:0023021] GO:0002223; GO:0004672; GO:0004674; GO:0004697; GO:0004699; GO:0004715; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0005886; GO:0005911; GO:0006468; GO:0006915; GO:0006921; GO:0007049; GO:0007165; GO:0007202; GO:0008047; GO:0008631; GO:0010469; GO:0016064; GO:0016363; GO:0016572; GO:0018105; GO:0018107; GO:0019899; GO:0019900; GO:0019901; GO:0023021; GO:0030168; GO:0030837; GO:0032079; GO:0032091; GO:0032147; GO:0032613; GO:0032615; GO:0032930; GO:0032956; GO:0034351; GO:0035307; GO:0038096; GO:0042100; GO:0042119; GO:0042307; GO:0042742; GO:0043407; GO:0043488; GO:0043560; GO:0046627; GO:0046872; GO:0048471; GO:0050728; GO:0050732; GO:0050821; GO:0051490; GO:0060326; GO:0060333; GO:0070062; GO:0070301; GO:0071447; GO:0090331; GO:0090398; GO:1900163; GO:1904385; GO:2000304; GO:2000753; GO:2000755; GO:2001022; GO:2001235 0 0 0 PF00130;PF00069;PF00433; Q05825 CHOYP_ATP5B.1.1 m.22321 sp ATPB_DROME 88.814 295 33 0 1 295 211 505 0 537 ATPB_DROME reviewed "ATP synthase subunit beta, mitochondrial (EC 3.6.3.14)" ATPsynbeta ATPsyn-beta CG11154 Drosophila melanogaster (Fruit fly) 505 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986]; lateral inhibition [GO:0046331]; regulation of glucose metabolic process [GO:0010906] GO:0005524; GO:0005739; GO:0005743; GO:0005811; GO:0010906; GO:0015986; GO:0015991; GO:0045261; GO:0046331; GO:0046933; GO:0046961 0 0 0 PF00006;PF02874; Q05AL1 CHOYP_BRAFLDRAFT_123389.1.1 m.57156 sp ARMC8_DANRE 56.414 647 281 1 46 691 25 671 0 744 ARMC8_DANRE reviewed Armadillo repeat-containing protein 8 armc8 zgc:153683 Danio rerio (Zebrafish) (Brachydanio rerio) 673 0 0 0 0 0 0 Q05AM5 CHOYP_ELP2.1.1 m.18394 sp ELP2_DANRE 46.793 842 391 20 22 836 10 821 0 745 ELP2_DANRE reviewed Elongator complex protein 2 (ELP2) elp2 si:dkey-190l1.1 zgc:153559 Danio rerio (Zebrafish) (Brachydanio rerio) 821 proteasome assembly [GO:0043248]; transcription elongation from RNA polymerase II promoter [GO:0006368] GO:0000123; GO:0000502; GO:0001191; GO:0005737; GO:0006368; GO:0008023; GO:0017053; GO:0033588; GO:0042393; GO:0043248; GO:0061133 0 0 0 PF00400; Q06190 CHOYP_PPP2R3B.1.2 m.366 sp P2R3A_HUMAN 61.137 422 158 3 178 594 698 1118 0 571 P2R3A_HUMAN reviewed Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) PPP2R3A PPP2R3 Homo sapiens (Human) 1150 eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; protein dephosphorylation [GO:0006470]; regulation of cell motility involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; somite development [GO:0061053]; Wnt signaling pathway involved in somitogenesis [GO:0090244] GO:0000159; GO:0001754; GO:0005509; GO:0006470; GO:0007525; GO:0008601; GO:0030674; GO:0045732; GO:0061053; GO:0090090; GO:0090244; GO:0090249; GO:0090263 0 0 0 PF13499; Q06190 CHOYP_PPP2R3B.2.2 m.34356 sp P2R3A_HUMAN 61.137 422 158 3 170 586 698 1118 0 575 P2R3A_HUMAN reviewed Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PP2A subunit B isoform PR72/PR130) (PP2A subunit B isoform R3 isoform) (PP2A subunit B isoforms B''-PR72/PR130) (PP2A subunit B isoforms B72/B130) (Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B) PPP2R3A PPP2R3 Homo sapiens (Human) 1150 eye photoreceptor cell differentiation [GO:0001754]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein catabolic process [GO:0045732]; protein dephosphorylation [GO:0006470]; regulation of cell motility involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; somite development [GO:0061053]; Wnt signaling pathway involved in somitogenesis [GO:0090244] GO:0000159; GO:0001754; GO:0005509; GO:0006470; GO:0007525; GO:0008601; GO:0030674; GO:0045732; GO:0061053; GO:0090090; GO:0090244; GO:0090249; GO:0090263 0 0 0 PF13499; Q06203 CHOYP_PUR1.1.1 m.16522 sp PUR1_HUMAN 63.424 514 168 3 9 502 4 517 0 681 PUR1_HUMAN reviewed Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) PPAT GPAT Homo sapiens (Human) 517 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; G1/S transition of mitotic cell cycle [GO:0000082]; glutamine catabolic process [GO:0006543]; kidney development [GO:0001822]; lactation [GO:0007595]; maternal process involved in female pregnancy [GO:0060135]; nucleoside metabolic process [GO:0009116]; organ regeneration [GO:0031100]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168] GO:0000082; GO:0001822; GO:0004044; GO:0005829; GO:0006164; GO:0006189; GO:0006543; GO:0007595; GO:0009113; GO:0009116; GO:0009168; GO:0031100; GO:0032869; GO:0035690; GO:0046872; GO:0051289; GO:0051539; GO:0060135 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. 0 cd06223; PF00156; Q06486 CHOYP_KC1D.1.3 m.12297 sp KC1D_RAT 78.641 412 66 7 1 392 1 410 0 640 KC1D_RAT reviewed Casein kinase I isoform delta (CKI-delta) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) Csnk1d Hckid Rattus norvegicus (Rat) 415 cellular response to nerve growth factor stimulus [GO:1990090]; circadian regulation of gene expression [GO:0032922]; endocytosis [GO:0006897]; Golgi organization [GO:0007030]; microtubule nucleation [GO:0007020]; nonmotile primary cilium assembly [GO:0035058]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of circadian rhythm [GO:0042752]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055] GO:0001934; GO:0001948; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005794; GO:0005813; GO:0005876; GO:0005886; GO:0006468; GO:0006897; GO:0007020; GO:0007030; GO:0008360; GO:0016055; GO:0016301; GO:0018105; GO:0032436; GO:0032922; GO:0034067; GO:0035058; GO:0042277; GO:0042752; GO:0043005; GO:0048471; GO:0050321; GO:0051225; GO:0061512; GO:0071539; GO:0090263; GO:1990090; GO:2000052 0 0 0 PF00069; Q06486 CHOYP_KC1D.2.3 m.36723 sp KC1D_RAT 75.971 412 75 6 1 392 1 408 0 613 KC1D_RAT reviewed Casein kinase I isoform delta (CKI-delta) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) Csnk1d Hckid Rattus norvegicus (Rat) 415 cellular response to nerve growth factor stimulus [GO:1990090]; circadian regulation of gene expression [GO:0032922]; endocytosis [GO:0006897]; Golgi organization [GO:0007030]; microtubule nucleation [GO:0007020]; nonmotile primary cilium assembly [GO:0035058]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of circadian rhythm [GO:0042752]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055] GO:0001934; GO:0001948; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005794; GO:0005813; GO:0005876; GO:0005886; GO:0006468; GO:0006897; GO:0007020; GO:0007030; GO:0008360; GO:0016055; GO:0016301; GO:0018105; GO:0032436; GO:0032922; GO:0034067; GO:0035058; GO:0042277; GO:0042752; GO:0043005; GO:0048471; GO:0050321; GO:0051225; GO:0061512; GO:0071539; GO:0090263; GO:1990090; GO:2000052 0 0 0 PF00069; Q06486 CHOYP_KC1D.3.3 m.61499 sp KC1D_RAT 78.641 412 66 7 1 392 1 410 0 640 KC1D_RAT reviewed Casein kinase I isoform delta (CKI-delta) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26) Csnk1d Hckid Rattus norvegicus (Rat) 415 cellular response to nerve growth factor stimulus [GO:1990090]; circadian regulation of gene expression [GO:0032922]; endocytosis [GO:0006897]; Golgi organization [GO:0007030]; microtubule nucleation [GO:0007020]; nonmotile primary cilium assembly [GO:0035058]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of circadian rhythm [GO:0042752]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055] GO:0001934; GO:0001948; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005794; GO:0005813; GO:0005876; GO:0005886; GO:0006468; GO:0006897; GO:0007020; GO:0007030; GO:0008360; GO:0016055; GO:0016301; GO:0018105; GO:0032436; GO:0032922; GO:0034067; GO:0035058; GO:0042277; GO:0042752; GO:0043005; GO:0048471; GO:0050321; GO:0051225; GO:0061512; GO:0071539; GO:0090263; GO:1990090; GO:2000052 0 0 0 PF00069; Q06725 CHOYP_N2F1A.1.1 m.63063 sp N2F1A_DANRE 76.62 432 69 7 12 436 5 411 0 655 N2F1A_DANRE reviewed Nuclear receptor subfamily 2 group F member 1-A (COUP transcription factor 1-A) (COUP-TFalpha-A) (zCOUP-TFI) (Seven-up related 44) (Svp[44]) (zSvp[44]) (Steroid receptor homolog SVP 44) nr2f1a nr2f1 svp44 si:dkeyp-10a3.1 Danio rerio (Zebrafish) (Brachydanio rerio) 411 "endothelial cell proliferation [GO:0001935]; transcription, DNA-templated [GO:0006351]; vasculature development [GO:0001944]" GO:0001935; GO:0001944; GO:0003707; GO:0004879; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; Q07130 CHOYP_UGPA.1.1 m.49579 sp UGPA_BOVIN 69.941 509 143 4 6 506 2 508 0 715 UGPA_BOVIN reviewed UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) (UDP-glucose pyrophosphorylase) (UDPGP) (UGPase) UGP2 Bos taurus (Bovine) 508 UDP-glucose metabolic process [GO:0006011] GO:0003983; GO:0005634; GO:0005737; GO:0006011; GO:0046872; GO:0070062 0 0 cd00897; PF01704; Q07496 CHOYP_EPHA7.1.1 m.9184 sp EPHA4_CHICK 46.686 1011 443 29 29 1008 30 975 0 813 EPHA4_CHICK reviewed Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (cEK8) EPHA4 CEK8 Gallus gallus (Chicken) 986 adult walking behavior [GO:0007628]; cell adhesion [GO:0007155]; corticospinal tract morphogenesis [GO:0021957]; ephrin receptor signaling pathway [GO:0048013]; fasciculation of motor neuron axon [GO:0097156]; fasciculation of sensory neuron axon [GO:0097155]; motor neuron axon guidance [GO:0008045]; negative regulation of axon regeneration [GO:0048681]; nephric duct morphogenesis [GO:0072178]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001108]; protein autophosphorylation [GO:0046777]; regulation of astrocyte differentiation [GO:0048710]; regulation of axonogenesis [GO:0050770]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of GTPase activity [GO:0043087]; segmentation [GO:0035282]; somitogenesis [GO:0001756] GO:0001756; GO:0004672; GO:0005004; GO:0005005; GO:0005524; GO:0005737; GO:0005886; GO:0005887; GO:0007155; GO:0007628; GO:0008045; GO:0018108; GO:0021957; GO:0030424; GO:0030425; GO:0031901; GO:0035282; GO:0043087; GO:0043507; GO:0046777; GO:0048013; GO:0048681; GO:0048710; GO:0050770; GO:0061001; GO:0072178; GO:0097155; GO:0097156; GO:0097161; GO:2001108 0 0 0 PF14575;PF01404;PF00041;PF07714;PF07647; Q07553 CHOYP_PHUM_PHUM591960.1.1 m.28280 sp GCY3E_DROME 41.225 1094 535 22 21 1082 36 1053 0 791 GCY3E_DROME reviewed Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) 1163 cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; signal transduction [GO:0007165] GO:0004383; GO:0004872; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007165; GO:0008074; GO:0019934 0 0 0 PF01094;PF00211;PF07714; Q07598 CHOYP_KS6A1.1.1 m.38387 sp NLTP_CHICK 67.11 526 167 5 7 528 16 539 0 742 NLTP_CHICK reviewed Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (Fragment) SCP2 Gallus gallus (Chicken) 547 cholesterol transport [GO:0030301]; phospholipid transport [GO:0015914]; steroid biosynthetic process [GO:0006694] GO:0005739; GO:0005777; GO:0006694; GO:0015248; GO:0015914; GO:0030301; GO:0032934; GO:0033814 0 0 0 PF02036;PF02803;PF00108; Q07598 CHOYP_LOC101069006.1.2 m.5485 sp NLTP_CHICK 71.389 360 101 2 3 361 15 373 0 554 NLTP_CHICK reviewed Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (Fragment) SCP2 Gallus gallus (Chicken) 547 cholesterol transport [GO:0030301]; phospholipid transport [GO:0015914]; steroid biosynthetic process [GO:0006694] GO:0005739; GO:0005777; GO:0006694; GO:0015248; GO:0015914; GO:0030301; GO:0032934; GO:0033814 0 0 0 PF02036;PF02803;PF00108; Q07598 CHOYP_LOC101069006.2.2 m.51654 sp NLTP_CHICK 66.792 530 170 5 124 649 12 539 0 741 NLTP_CHICK reviewed Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (Fragment) SCP2 Gallus gallus (Chicken) 547 cholesterol transport [GO:0030301]; phospholipid transport [GO:0015914]; steroid biosynthetic process [GO:0006694] GO:0005739; GO:0005777; GO:0006694; GO:0015248; GO:0015914; GO:0030301; GO:0032934; GO:0033814 0 0 0 PF02036;PF02803;PF00108; Q07864 CHOYP_DPOE1.1.1 m.17256 sp DPOE1_HUMAN 64.519 2297 779 15 1 2272 1 2286 0 3108 DPOE1_HUMAN reviewed DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) POLE POLE1 Homo sapiens (Human) 2286 "base-excision repair, gap-filling [GO:0006287]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA synthesis involved in DNA repair [GO:0000731]; embryonic organ development [GO:0048568]; G1/S transition of mitotic cell cycle [GO:0000082]; nucleotide-excision repair, DNA gap filling [GO:0006297]; telomere maintenance via recombination [GO:0000722]" GO:0000082; GO:0000166; GO:0000722; GO:0000731; GO:0003677; GO:0003682; GO:0003887; GO:0005634; GO:0005654; GO:0005886; GO:0006260; GO:0006270; GO:0006287; GO:0006297; GO:0008270; GO:0008408; GO:0008622; GO:0048568; GO:0051539 0 0 0 PF00136;PF03104;PF08490; Q07890 CHOYP_SOS1.1.1 m.52801 sp SOS2_HUMAN 54.076 1104 468 19 11 1094 15 1099 0 1118 SOS2_HUMAN reviewed Son of sevenless homolog 2 (SOS-2) SOS2 Homo sapiens (Human) 1332 positive regulation of apoptotic process [GO:0043065]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264] GO:0003677; GO:0005085; GO:0005089; GO:0005829; GO:0007264; GO:0035023; GO:0043065; GO:0051056; GO:0051057 0 0 cd06224; PF00125;PF00169;PF00617;PF00618;PF00621; Q07912 CHOYP_TNK2.1.1 m.9254 sp ACK1_HUMAN 50.227 661 280 15 1 633 1 640 0 599 ACK1_HUMAN reviewed Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2) TNK2 ACK1 Homo sapiens (Human) 1038 cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endocytosis [GO:0006897]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; regulation of cell proliferation [GO:0042127]; regulation of clathrin-mediated endocytosis [GO:2000369]; small GTPase mediated signal transduction [GO:0007264]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004674; GO:0004712; GO:0004713; GO:0004715; GO:0005095; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005768; GO:0005886; GO:0005905; GO:0005912; GO:0006897; GO:0007166; GO:0007169; GO:0007264; GO:0016020; GO:0016310; GO:0016477; GO:0030136; GO:0030154; GO:0030659; GO:0031234; GO:0038083; GO:0042127; GO:0042802; GO:0045087; GO:0046872; GO:0050699; GO:0050731; GO:0070436; GO:2000369 0 0 0 PF09027;PF11555;PF07714;PF14604; Q08462 CHOYP_APLB.1.1 m.8916 sp ADCY2_HUMAN 40.689 1074 548 26 60 1074 33 1076 0 733 ADCY2_HUMAN reviewed Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) ADCY2 KIAA1060 Homo sapiens (Human) 1091 activation of adenylate cyclase activity [GO:0007190]; activation of protein kinase A activity [GO:0034199]; adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933]; cellular response to forskolin [GO:1904322]; cellular response to glucagon stimulus [GO:0071377]; renal water homeostasis [GO:0003091] GO:0000287; GO:0003091; GO:0004016; GO:0005524; GO:0005622; GO:0005737; GO:0005886; GO:0005887; GO:0006171; GO:0007188; GO:0007189; GO:0007190; GO:0007193; GO:0008179; GO:0016020; GO:0019933; GO:0030145; GO:0030425; GO:0034199; GO:0045121; GO:0046982; GO:0071377; GO:1904322 0 0 0 PF16214;PF06327;PF00211; Q08AX9 CHOYP_K1841.1.1 m.56085 sp K1841_XENLA 46.328 708 293 20 19 677 18 687 0 546 K1841_XENLA reviewed Uncharacterized protein KIAA1841 homolog 0 Xenopus laevis (African clawed frog) 715 0 0 0 0 0 PF11822; Q08D64 CHOYP_ABCB6.3.3 m.53101 sp ABCB6_XENTR 56.092 829 338 7 3 824 7 816 0 880 ABCB6_XENTR reviewed "ATP-binding cassette sub-family B member 6, mitochondrial" abcb6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 849 cellular iron ion homeostasis [GO:0006879]; transmembrane transport [GO:0055085] GO:0005524; GO:0005741; GO:0005743; GO:0005783; GO:0005794; GO:0005886; GO:0006879; GO:0016021; GO:0042626; GO:0055085 0 0 0 PF00664;PF00005;PF16185; Q08DZ2 CHOYP_PRP4B.1.1 m.28423 sp PRP4B_BOVIN 75 388 90 2 722 1106 625 1008 0 642 PRP4B_BOVIN reviewed Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre-mRNA-processing factor 4 homolog) PRPF4B Bos taurus (Bovine) 1008 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0004674; GO:0005524; GO:0005654; GO:0005694; GO:0006397; GO:0008380; GO:0044822; GO:0071013 0 0 0 PF00069; Q08E38 CHOYP_LOC100376500.1.1 m.36606 sp PRP19_BOVIN 69.291 508 152 2 4 511 1 504 0 758 PRP19_BOVIN reviewed Pre-mRNA-processing factor 19 (EC 6.3.2.-) (PRP19/PSO4 homolog) PRPF19 Bos taurus (Bovine) 504 "cellular protein localization [GO:0034613]; double-strand break repair via nonhomologous end joining [GO:0006303]; inner cell mass cell proliferation [GO:0001833]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; signal transduction involved in DNA damage checkpoint [GO:0072422]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000245; GO:0000398; GO:0000974; GO:0001833; GO:0005634; GO:0005662; GO:0005737; GO:0005811; GO:0005819; GO:0006303; GO:0008610; GO:0010498; GO:0016020; GO:0016607; GO:0016874; GO:0034450; GO:0034613; GO:0035861; GO:0045665; GO:0048026; GO:0048711; GO:0061630; GO:0070534; GO:0071013; GO:0072422 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UMS4}. 0 0 PF08606;PF04564;PF00400; Q08E38 CHOYP_PRPF19.1.1 m.55553 sp PRP19_BOVIN 69.291 508 152 2 1 508 1 504 0 758 PRP19_BOVIN reviewed Pre-mRNA-processing factor 19 (EC 6.3.2.-) (PRP19/PSO4 homolog) PRPF19 Bos taurus (Bovine) 504 "cellular protein localization [GO:0034613]; double-strand break repair via nonhomologous end joining [GO:0006303]; inner cell mass cell proliferation [GO:0001833]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; signal transduction involved in DNA damage checkpoint [GO:0072422]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000245; GO:0000398; GO:0000974; GO:0001833; GO:0005634; GO:0005662; GO:0005737; GO:0005811; GO:0005819; GO:0006303; GO:0008610; GO:0010498; GO:0016020; GO:0016607; GO:0016874; GO:0034450; GO:0034613; GO:0035861; GO:0045665; GO:0048026; GO:0048711; GO:0061630; GO:0070534; GO:0071013; GO:0072422 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UMS4}. 0 0 PF08606;PF04564;PF00400; Q08J23 CHOYP_NSUN2.1.1 m.14138 sp NSUN2_HUMAN 46.277 752 351 16 15 740 35 759 0 651 NSUN2_HUMAN reviewed tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4) NSUN2 SAKI TRM4 Homo sapiens (Human) 767 cell division [GO:0051301]; meiotic cell cycle checkpoint [GO:0033313]; mitotic nuclear division [GO:0007067]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400] GO:0000049; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005819; GO:0006400; GO:0007067; GO:0007286; GO:0016428; GO:0030488; GO:0033313; GO:0033391; GO:0044822; GO:0051301 0 0 0 PF01189; Q09428 CHOYP_BRAFLDRAFT_118957.1.1 m.51715 sp ABCC8_HUMAN 41.726 985 503 10 750 1702 636 1581 0 754 ABCC8_HUMAN reviewed ATP-binding cassette sub-family C member 8 (Sulfonylurea receptor 1) ABCC8 HRINS SUR SUR1 Homo sapiens (Human) 1581 cellular response to organic substance [GO:0071310]; negative regulation of insulin secretion [GO:0046676]; positive regulation of potassium ion transport [GO:0043268]; potassium ion transport [GO:0006813]; regulation of insulin secretion [GO:0050796]; response to drug [GO:0042493]; response to insulin [GO:0032868]; response to lipopolysaccharide [GO:0032496]; response to pH [GO:0009268]; response to zinc ion [GO:0010043]; transmembrane transport [GO:0055085] GO:0005267; GO:0005524; GO:0005886; GO:0006813; GO:0008076; GO:0008281; GO:0009268; GO:0010043; GO:0015272; GO:0030672; GO:0032496; GO:0032868; GO:0042383; GO:0042493; GO:0043225; GO:0043268; GO:0044325; GO:0046676; GO:0050796; GO:0055085; GO:0071310 0 0 0 PF00664;PF00005; Q09499 CHOYP_BRAFLDRAFT_118819.2.2 m.57663 sp IRE1_CAEEL 44.014 877 451 18 36 883 43 908 0 709 IRE1_CAEEL reviewed Serine/threonine-protein kinase/endoribonuclease ire-1 (Inositol-requiring protein 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] ire-1 C41C4.4 Caenorhabditis elegans 967 endoplasmic reticulum unfolded protein response [GO:0030968]; mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response [GO:0030969]; nematode larval development [GO:0002119]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein phosphorylation [GO:0006468]; response to hypoxia [GO:0001666]; response to topologically incorrect protein [GO:0035966]; response to tunicamycin [GO:1904576] GO:0001666; GO:0002119; GO:0004521; GO:0004674; GO:0005524; GO:0006468; GO:0006990; GO:0030176; GO:0030968; GO:0030969; GO:0035966; GO:0090305; GO:1902255; GO:1904576 0 0 0 PF00069;PF01011;PF06479; Q09LZ8 CHOYP_LOC100375368.1.1 m.48556 sp CBPC6_MOUSE 67.452 467 144 3 7 473 10 468 0 687 CBPC6_MOUSE reviewed Cytosolic carboxypeptidase 6 (EC 3.4.17.-) (ATP/GTP-binding protein-like 4) Agbl4 Ccp6 Mus musculus (Mouse) 540 C-terminal protein deglutamylation [GO:0035609]; defense response to virus [GO:0051607]; protein deglutamylation [GO:0035608]; protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005794; GO:0005814; GO:0005829; GO:0008270; GO:0015631; GO:0035608; GO:0035609; GO:0035610; GO:0036064; GO:0051607 0 0 0 PF00246; Q0E908 CHOYP_DPER_GL17438.1.1 m.11680 sp HIL_DROME 38.3 906 443 19 21 900 1 816 0 627 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q0IID9 CHOYP_BRAFLDRAFT_224325.3.3 m.52906 sp GLPK_BOVIN 65 540 182 2 6 539 12 550 0 712 GLPK_BOVIN reviewed Glycerol kinase (GK) (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) GK Bos taurus (Bovine) 559 glycerol-3-phosphate biosynthetic process [GO:0046167]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; triglyceride metabolic process [GO:0006641] GO:0004370; GO:0005524; GO:0005739; GO:0005741; GO:0006071; GO:0006641; GO:0019563; GO:0046167 PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. 0 0 PF02782;PF00370; Q0IIF7 CHOYP_LOC100373353.1.1 m.50175 sp UBP14_BOVIN 62.284 464 162 3 1 454 27 487 0 616 UBP14_BOVIN reviewed Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) USP14 Bos taurus (Bovine) 494 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000502; GO:0005737; GO:0005886; GO:0006511; GO:0016579; GO:0036459; GO:0070628 0 0 0 PF00443; Q0III3 CHOYP_DC1I2.2.3 m.54049 sp DC1I2_BOVIN 65.558 511 168 3 84 593 104 607 0 684 DC1I2_BOVIN reviewed "Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)" DYNC1I2 Bos taurus (Bovine) 612 microtubule-based movement [GO:0007018]; transport [GO:0006810] GO:0003774; GO:0005737; GO:0005868; GO:0005874; GO:0006810; GO:0007018; GO:0031982 0 0 0 PF11540;PF00400; Q0IJ05 CHOYP_OSBL9.1.2 m.17667 sp OSBL9_XENTR 55.285 738 256 12 18 688 3 733 0 791 OSBL9_XENTR reviewed Oxysterol-binding protein-related protein 9 osbpl9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 739 lipid transport [GO:0006869] GO:0006869; GO:0008289 0 0 0 PF01237;PF00169; Q0IJ05 CHOYP_OSBL9.2.2 m.35246 sp OSBL9_XENTR 55.858 734 286 11 2 700 3 733 0 803 OSBL9_XENTR reviewed Oxysterol-binding protein-related protein 9 osbpl9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 739 lipid transport [GO:0006869] GO:0006869; GO:0008289 0 0 0 PF01237;PF00169; Q0KK59 CHOYP_UNC79.2.4 m.39641 sp UNC79_MOUSE 38.273 938 510 17 5 885 161 1086 0 694 UNC79_MOUSE reviewed Protein unc-79 homolog Unc79 Kiaa1409 Mus musculus (Mouse) 2596 adult behavior [GO:0030534]; behavioral response to ethanol [GO:0048149]; multicellular organism growth [GO:0035264] GO:0016021; GO:0030534; GO:0035264; GO:0048149 0 0 0 0 Q0KK59 CHOYP_UNC79.3.4 m.41643 sp UNC79_MOUSE 38.578 858 468 13 2 808 333 1182 0 627 UNC79_MOUSE reviewed Protein unc-79 homolog Unc79 Kiaa1409 Mus musculus (Mouse) 2596 adult behavior [GO:0030534]; behavioral response to ethanol [GO:0048149]; multicellular organism growth [GO:0035264] GO:0016021; GO:0030534; GO:0035264; GO:0048149 0 0 0 0 Q0KL02 CHOYP_TRIO.1.1 m.49282 sp TRIO_MOUSE 46.81 2006 934 29 1 1928 333 2283 0 1778 TRIO_MOUSE reviewed Triple functional domain protein (EC 2.7.11.1) Trio Mus musculus (Mouse) 3102 regulation of Rho protein signal transduction [GO:0035023] GO:0004674; GO:0005089; GO:0005524; GO:0005737; GO:0035023 0 0 0 PF00650;PF07679;PF00169;PF00069;PF00621;PF00018;PF00435; Q0MQI4 CHOYP_BRAFLDRAFT_273832.1.1 m.56325 sp NDUV1_PONPY 84.471 425 66 0 32 456 29 453 0 761 NDUV1_PONPY reviewed "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-51kD) (CI-51kD) (NADH-ubiquinone oxidoreductase 51 kDa subunit)" NDUFV1 Pongo pygmaeus (Bornean orangutan) 464 0 GO:0005743; GO:0008137; GO:0010181; GO:0046872; GO:0051287; GO:0051539; GO:0070469 0 0 0 PF01512;PF10589;PF10531; Q0P4F7 CHOYP_LOC100374370.1.1 m.56335 sp ACSF2_DANRE 49.462 558 279 3 45 600 50 606 0 573 ACSF2_DANRE reviewed "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) 606 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005739; GO:0006631; GO:0016874 0 0 0 PF00501;PF13193; Q0P4Y8 CHOYP_LOC583944.1.1 m.62226 sp LMF2_XENTR 49.435 619 290 11 32 634 1 612 0 572 LMF2_XENTR reviewed Lipase maturation factor 2 lmf2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 707 0 GO:0005789; GO:0016021 0 0 0 PF06762; Q0P5W1 CHOYP_VPS8.1.1 m.51272 sp VPS8_MOUSE 48.827 1407 657 21 14 1378 41 1426 0 1384 VPS8_MOUSE reviewed Vacuolar protein sorting-associated protein 8 homolog Vps8 Kiaa0804 Mus musculus (Mouse) 1427 endosomal vesicle fusion [GO:0034058] GO:0005769; GO:0008270; GO:0033263; GO:0034058 0 0 0 PF12816; Q0R4F1 CHOYP_PIF1.1.1 m.12554 sp PIF1_XENLA 53.945 621 274 4 4 616 11 627 0 694 PIF1_XENLA reviewed ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) pif1 Xenopus laevis (African clawed frog) 635 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; mitochondrial genome maintenance [GO:0000002]; telomere maintenance [GO:0000723] GO:0000002; GO:0000723; GO:0003677; GO:0005524; GO:0005634; GO:0005739; GO:0006281; GO:0006310; GO:0043141 0 0 0 PF02689;PF05970; Q0V8F1 CHOYP_BRAFLDRAFT_117106.1.1 m.49365 sp CORO7_BOVIN 42.368 963 498 11 4 959 3 915 0 761 CORO7_BOVIN reviewed Coronin-7 (Crn7) CORO7 Bos taurus (Bovine) 915 actin filament polymerization [GO:0030041]; Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] GO:0000139; GO:0003779; GO:0005794; GO:0005802; GO:0005829; GO:0006895; GO:0015031; GO:0016023; GO:0030041 0 0 0 PF08953;PF00400; Q0V8S0 CHOYP_LOC100378364.1.1 m.53053 sp HGS_BOVIN 46.377 828 336 18 6 780 5 777 0 650 HGS_BOVIN reviewed Hepatocyte growth factor-regulated tyrosine kinase substrate HGS Bos taurus (Bovine) 777 membrane invagination [GO:0010324]; negative regulation of JAK-STAT cascade [GO:0046426]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of gene expression [GO:0010628]; protein localization to membrane [GO:0072657]; protein targeting to lysosome [GO:0006622]; regulation of MAP kinase activity [GO:0043405] GO:0006622; GO:0010324; GO:0010628; GO:0031901; GO:0032585; GO:0043405; GO:0046426; GO:0046872; GO:0070062; GO:0072657; GO:1903543 0 0 0 PF01363;PF12210;PF00790; Q0V9K5 CHOYP_RFX3.1.1 m.55790 sp RFX3_XENTR 59.547 618 180 12 81 635 52 662 0 720 RFX3_XENTR reviewed Transcription factor RFX3 (Regulatory factor X 3) rfx3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 749 "cell differentiation [GO:0030154]; cilium-dependent cell motility [GO:0060285]; endocrine pancreas development [GO:0031018]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; regulation of insulin secretion [GO:0050796]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0006357; GO:0030154; GO:0031018; GO:0044212; GO:0050796; GO:0060285; GO:0060287 0 0 0 PF04589;PF02257; Q0V9L1 CHOYP_MMS19.1.1 m.18650 sp MMS19_XENTR 35.953 1018 616 14 8 997 12 1021 0 558 MMS19_XENTR reviewed MMS19 nucleotide excision repair protein homolog (MMS19-like protein) mms19 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1022 cellular response to DNA damage stimulus [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; iron-sulfur cluster assembly [GO:0016226] GO:0005634; GO:0005737; GO:0005819; GO:0006259; GO:0006281; GO:0006974; GO:0016226; GO:0097361 0 0 0 PF12460; Q0V9R3 CHOYP_LOC100372341.1.1 m.46956 sp DI3L2_XENTR 53.514 811 344 8 387 1179 36 831 0 878 DI3L2_XENTR reviewed DIS3-like exonuclease 2 (EC 3.1.13.-) dis3l2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 834 "cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic nuclear division [GO:0007067]; mRNA catabolic process [GO:0006402]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; stem cell population maintenance [GO:0019827]" GO:0000175; GO:0000176; GO:0000177; GO:0000291; GO:0000932; GO:0003723; GO:0005737; GO:0006364; GO:0006402; GO:0007067; GO:0010587; GO:0016075; GO:0019827; GO:0034427; GO:0046872; GO:0051301; GO:1990074 0 0 0 0 Q0V9R4 CHOYP_LOC100374491.1.1 m.6498 sp CCD39_XENTR 56.995 872 374 1 47 918 5 875 0 953 CCD39_XENTR reviewed Coiled-coil domain-containing protein 39 ccdc39 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 945 axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; cilium movement [GO:0003341]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; inner dynein arm assembly [GO:0036159] GO:0003341; GO:0005737; GO:0005930; GO:0036159; GO:0060285; GO:0060287; GO:0070286 0 0 0 0 Q0V9S9 CHOYP_LOC100366728.1.1 m.57449 sp DRC7_XENTR 51.669 809 367 5 11 818 68 853 0 814 DRC7_XENTR reviewed Dynein regulatory complex subunit 7 (Coiled-coil domain-containing protein 135) (Coiled-coil domain-containing protein lobo homolog) drc7 ccdc135 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 856 0 GO:0005737; GO:0005856; GO:0031514 0 0 0 0 Q0VA16 CHOYP_WDR70.1.1 m.7199 sp WDR70_XENTR 53.81 630 271 9 86 713 11 622 0 665 WDR70_XENTR reviewed WD repeat-containing protein 70 wdr70 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 622 0 0 0 0 0 PF00400; Q0VD48 CHOYP_VPS4B.2.2 m.30053 sp VPS4B_BOVIN 77.201 443 94 3 19 458 6 444 0 709 VPS4B_BOVIN reviewed Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) VPS4B Bos taurus (Bovine) 444 cell separation after cytokinesis [GO:0000920]; cholesterol transport [GO:0030301]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; late endosomal microautophagy [GO:0061738]; mitotic metaphase plate congression [GO:0007080]; multivesicular body assembly [GO:0036258]; negative regulation of cell death [GO:0060548]; negative regulation of exosomal secretion [GO:1903542]; nucleus organization [GO:0006997]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of viral release from host cell [GO:1902188]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; protein transport [GO:0015031]; regulation of mitotic spindle assembly [GO:1901673]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; viral budding via host ESCRT complex [GO:0039702]; viral release from host cell [GO:0019076] GO:0000920; GO:0000922; GO:0005524; GO:0005634; GO:0005813; GO:0005829; GO:0006813; GO:0006997; GO:0007033; GO:0007080; GO:0010971; GO:0015031; GO:0019076; GO:0030301; GO:0031902; GO:0032510; GO:0033993; GO:0036258; GO:0039702; GO:0042623; GO:0043162; GO:0051261; GO:0060548; GO:0061738; GO:0070062; GO:0090543; GO:0090611; GO:1901673; GO:1902188; GO:1903542; GO:1903543; GO:1903724 0 0 0 PF00004;PF04212;PF09336; Q0VGW6 CHOYP_S12A9.1.1 m.13549 sp S12A9_XENLA 46.205 896 430 10 62 942 41 899 0 789 S12A9_XENLA reviewed Solute carrier family 12 member 9 (Cation-chloride cotransporter-interacting protein 1) slc12a9 cip1 Xenopus laevis (African clawed frog) 899 ion transport [GO:0006811]; transmembrane transport [GO:0055085] GO:0005215; GO:0005886; GO:0006811; GO:0016021; GO:0055085 0 0 0 PF00324;PF03522; Q10471 CHOYP_GALT2.1.1 m.54493 sp GALT2_HUMAN 57.534 584 228 4 3 583 2 568 0 697 GALT2_HUMAN reviewed Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form] GALNT2 Homo sapiens (Human) 571 immunoglobulin biosynthetic process [GO:0002378]; O-glycan processing [GO:0016266]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; protein O-linked glycosylation via threonine [GO:0018243] GO:0000139; GO:0002378; GO:0004653; GO:0005789; GO:0005794; GO:0005795; GO:0006493; GO:0016020; GO:0016266; GO:0018242; GO:0018243; GO:0030145; GO:0030173; GO:0030246; GO:0032580; GO:0048471; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q10569 CHOYP_CPSF1.1.1 m.27767 sp CPSF1_BOVIN 56.759 1450 603 12 1 1432 1 1444 0 1695 CPSF1_BOVIN reviewed Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) CPSF1 CPSF160 Bos taurus (Bovine) 1444 mRNA cleavage [GO:0006379]; mRNA polyadenylation [GO:0006378] GO:0003729; GO:0005847; GO:0006378; GO:0006379; GO:0035925 0 0 0 PF03178; Q10751 CHOYP_ACE.1.4 m.2762 sp ACE_CHICK 52.745 1111 500 9 226 1318 24 1127 0 1197 ACE_CHICK reviewed Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Fragment) ACE DCP1 Gallus gallus (Chicken) 1193 cell proliferation [GO:0008283]; primitive erythrocyte differentiation [GO:0060319] GO:0004180; GO:0008237; GO:0008239; GO:0008241; GO:0008270; GO:0008283; GO:0016021; GO:0060319 0 0 0 PF01401; Q10751 CHOYP_ACE.2.4 m.5302 sp ACE_CHICK 56.417 1122 460 12 689 1792 9 1119 0 1298 ACE_CHICK reviewed Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Fragment) ACE DCP1 Gallus gallus (Chicken) 1193 cell proliferation [GO:0008283]; primitive erythrocyte differentiation [GO:0060319] GO:0004180; GO:0008237; GO:0008239; GO:0008241; GO:0008270; GO:0008283; GO:0016021; GO:0060319 0 0 0 PF01401; Q10751 CHOYP_ACE.3.4 m.12875 sp ACE_CHICK 57.696 1085 429 13 246 1312 38 1110 0 1292 ACE_CHICK reviewed Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (Fragment) ACE DCP1 Gallus gallus (Chicken) 1193 cell proliferation [GO:0008283]; primitive erythrocyte differentiation [GO:0060319] GO:0004180; GO:0008237; GO:0008239; GO:0008241; GO:0008270; GO:0008283; GO:0016021; GO:0060319 0 0 0 PF01401; Q11011 CHOYP_PSA.1.1 m.27259 sp PSA_MOUSE 62.946 869 318 3 59 925 44 910 0 1149 PSA_MOUSE reviewed Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S) Npepps Psa Mus musculus (Mouse) 920 cellular response to hypoxia [GO:0071456]; peptide catabolic process [GO:0043171]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis [GO:0006508] GO:0004177; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006508; GO:0008270; GO:0042277; GO:0043171; GO:0070006; GO:0070062; GO:0071456; GO:1903955 0 0 0 PF11838;PF01433; Q12756 CHOYP_KIF1A.1.1 m.44825 sp KIF1A_HUMAN 60.87 989 290 13 1 953 91 1018 0 1108 KIF1A_HUMAN reviewed Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) KIF1A ATSV C2orf20 Homo sapiens (Human) 1690 anterograde axonal transport [GO:0008089] GO:0003774; GO:0003777; GO:0005524; GO:0005871; GO:0005874; GO:0008089; GO:0016887; GO:1904115 0 0 0 PF12473;PF00498;PF12423;PF00225;PF16183;PF00169; Q12834 CHOYP_LOC100378644.2.2 m.58496 sp CDC20_HUMAN 56.725 513 191 7 1 509 1 486 0 598 CDC20_HUMAN reviewed Cell division cycle protein 20 homolog (p55CDC) CDC20 Homo sapiens (Human) 499 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of cell proliferation [GO:0008284]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of dendrite development [GO:0050773]; regulation of meiotic nuclear division [GO:0040020]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; sister chromatid cohesion [GO:0007062] GO:0000922; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0007049; GO:0007062; GO:0007067; GO:0008022; GO:0008284; GO:0019899; GO:0031145; GO:0031915; GO:0040020; GO:0042787; GO:0043161; GO:0043234; GO:0048471; GO:0050773; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0090129; GO:0097027; GO:1904668 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12894;PF00400; Q12959 CHOYP_SAP.1.2 m.13958 sp DLG1_HUMAN 56.572 951 286 17 1 871 1 904 0 989 DLG1_HUMAN reviewed Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) DLG1 Homo sapiens (Human) 904 actin filament organization [GO:0007015]; activation of protein kinase activity [GO:0032147]; amyloid precursor protein metabolic process [GO:0042982]; astral microtubule organization [GO:0030953]; bicellular tight junction assembly [GO:0070830]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular protein complex localization [GO:0034629]; chemical synaptic transmission [GO:0007268]; cortical actin cytoskeleton organization [GO:0030866]; cortical microtubule organization [GO:0043622]; embryonic skeletal system morphogenesis [GO:0048704]; endothelial cell proliferation [GO:0001935]; establishment of centrosome localization [GO:0051660]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; hard palate development [GO:0060022]; immunological synapse formation [GO:0001771]; lens development in camera-type eye [GO:0002088]; membrane raft organization [GO:0031579]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of p38MAPK cascade [GO:1903753]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; peristalsis [GO:0030432]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell proliferation [GO:0008284]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of potassium ion transport [GO:0043268]; protein localization to plasma membrane [GO:0072659]; receptor clustering [GO:0043113]; receptor localization to synapse [GO:0097120]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; regulation of myelination [GO:0031641]; regulation of sodium ion transmembrane transport [GO:1902305]; reproductive structure development [GO:0048608]; single organismal cell-cell adhesion [GO:0016337]; smooth muscle tissue development [GO:0048745]; T cell activation [GO:0042110]; T cell cytokine production [GO:0002369]; viral process [GO:0016032] GO:0000122; GO:0001658; GO:0001771; GO:0001772; GO:0001935; GO:0002088; GO:0002369; GO:0004385; GO:0004721; GO:0005605; GO:0005634; GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0005829; GO:0005874; GO:0005886; GO:0005911; GO:0005913; GO:0005923; GO:0007015; GO:0007093; GO:0007163; GO:0007268; GO:0007399; GO:0008022; GO:0008092; GO:0008284; GO:0008360; GO:0009898; GO:0014069; GO:0014704; GO:0015276; GO:0015459; GO:0016032; GO:0016323; GO:0016328; GO:0016337; GO:0019901; GO:0019902; GO:0030054; GO:0030432; GO:0030838; GO:0030866; GO:0030953; GO:0031253; GO:0031434; GO:0031579; GO:0031594; GO:0031641; GO:0032147; GO:0033268; GO:0034629; GO:0035255; GO:0035748; GO:0042110; GO:0042130; GO:0042383; GO:0042391; GO:0042982; GO:0043113; GO:0043219; GO:0043268; GO:0043622; GO:0044325; GO:0045121; GO:0045197; GO:0045211; GO:0045930; GO:0048471; GO:0048608; GO:0048704; GO:0048745; GO:0050680; GO:0051660; GO:0051898; GO:0060022; GO:0070062; GO:0070373; GO:0070830; GO:0072659; GO:0090004; GO:0097016; GO:0097025; GO:0097120; GO:0098641; GO:1902305; GO:1903753 0 0 0 PF00625;PF09058;PF10608;PF00595;PF10600;PF07653; Q12965 CHOYP_MYO1E.1.1 m.49109 sp MYO1E_HUMAN 65.927 1127 345 13 5 1119 9 1108 0 1498 MYO1E_HUMAN reviewed Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E) MYO1E MYO1C Homo sapiens (Human) 1108 actin filament-based movement [GO:0030048]; endocytosis [GO:0006897]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; glomerular visceral epithelial cell development [GO:0072015]; in utero embryonic development [GO:0001701]; nitrogen compound metabolic process [GO:0006807]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic hemopoiesis [GO:0035166]; vasculogenesis [GO:0001570] GO:0000146; GO:0001570; GO:0001701; GO:0003094; GO:0003774; GO:0005516; GO:0005524; GO:0005737; GO:0005856; GO:0005903; GO:0005911; GO:0005912; GO:0006807; GO:0006897; GO:0015629; GO:0016459; GO:0030048; GO:0030136; GO:0032836; GO:0035091; GO:0035166; GO:0042623; GO:0048008; GO:0051015; GO:0070062; GO:0072015 0 0 0 PF00063;PF06017;PF00018; Q12986 CHOYP_NFX1.1.2 m.13487 sp NFX1_HUMAN 51.609 746 343 11 551 1284 341 1080 0 751 NFX1_HUMAN reviewed "Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding protein 1)" NFX1 NFX2 Homo sapiens (Human) 1120 inflammatory response [GO:0006954]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032] GO:0000122; GO:0000977; GO:0001078; GO:0003700; GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006366; GO:0006954; GO:0008270; GO:0016032; GO:0016874; GO:0044822; GO:0045347 0 0 0 PF01424;PF01422; Q12996 CHOYP_CSTF3.1.1 m.10636 sp CSTF3_HUMAN 65.537 708 234 5 18 718 13 717 0 977 CSTF3_HUMAN reviewed Cleavage stimulation factor subunit 3 (CF-1 77 kDa subunit) (Cleavage stimulation factor 77 kDa subunit) (CSTF 77 kDa subunit) (CstF-77) CSTF3 Homo sapiens (Human) 717 "mRNA 3'-end processing [GO:0031124]; mRNA cleavage [GO:0006379]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0006369; GO:0006378; GO:0006379; GO:0031124; GO:0044822 0 0 0 PF05843; Q13002 CHOYP_LOC100533316.1.2 m.7619 sp GRIK2_HUMAN 40.877 844 457 18 49 874 52 871 0 647 GRIK2_HUMAN reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 GLUR6 Homo sapiens (Human) 908 "behavioral fear response [GO:0001662]; cellular calcium ion homeostasis [GO:0006874]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular protein transport [GO:0006886]; modulation of synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuronal action potential [GO:0019228]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]; transport [GO:0006810]" GO:0001662; GO:0005234; GO:0005886; GO:0005887; GO:0006810; GO:0006874; GO:0006886; GO:0007215; GO:0007268; GO:0014069; GO:0015276; GO:0015277; GO:0019228; GO:0030054; GO:0032839; GO:0032983; GO:0035249; GO:0042734; GO:0043113; GO:0043195; GO:0043204; GO:0043524; GO:0043525; GO:0045211; GO:0046328; GO:0048169; GO:0048172; GO:0050804; GO:0050806; GO:0051402; GO:0051967; GO:0060079; GO:0060080 0 0 0 PF01094;PF00060;PF10613; Q13002 CHOYP_LOC100533316.2.2 m.47772 sp GRIK2_HUMAN 44.828 870 454 12 7 867 19 871 0 779 GRIK2_HUMAN reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 GLUR6 Homo sapiens (Human) 908 "behavioral fear response [GO:0001662]; cellular calcium ion homeostasis [GO:0006874]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular protein transport [GO:0006886]; modulation of synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuronal action potential [GO:0019228]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]; transport [GO:0006810]" GO:0001662; GO:0005234; GO:0005886; GO:0005887; GO:0006810; GO:0006874; GO:0006886; GO:0007215; GO:0007268; GO:0014069; GO:0015276; GO:0015277; GO:0019228; GO:0030054; GO:0032839; GO:0032983; GO:0035249; GO:0042734; GO:0043113; GO:0043195; GO:0043204; GO:0043524; GO:0043525; GO:0045211; GO:0046328; GO:0048169; GO:0048172; GO:0050804; GO:0050806; GO:0051402; GO:0051967; GO:0060079; GO:0060080 0 0 0 PF01094;PF00060;PF10613; Q13002 CHOYP_LOC663783.1.1 m.62943 sp GRIK2_HUMAN 38.366 808 426 14 1 755 99 887 0 579 GRIK2_HUMAN reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 GLUR6 Homo sapiens (Human) 908 "behavioral fear response [GO:0001662]; cellular calcium ion homeostasis [GO:0006874]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular protein transport [GO:0006886]; modulation of synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuronal action potential [GO:0019228]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]; transport [GO:0006810]" GO:0001662; GO:0005234; GO:0005886; GO:0005887; GO:0006810; GO:0006874; GO:0006886; GO:0007215; GO:0007268; GO:0014069; GO:0015276; GO:0015277; GO:0019228; GO:0030054; GO:0032839; GO:0032983; GO:0035249; GO:0042734; GO:0043113; GO:0043195; GO:0043204; GO:0043524; GO:0043525; GO:0045211; GO:0046328; GO:0048169; GO:0048172; GO:0050804; GO:0050806; GO:0051402; GO:0051967; GO:0060079; GO:0060080 0 0 0 PF01094;PF00060;PF10613; Q13042 CHOYP_LOC101158148.1.1 m.14871 sp CDC16_HUMAN 60.521 537 204 3 22 551 1 536 0 694 CDC16_HUMAN reviewed Cell division cycle protein 16 homolog (Anaphase-promoting complex subunit 6) (APC6) (CDC16 homolog) (CDC16Hs) (Cyclosome subunit 6) CDC16 ANAPC6 Homo sapiens (Human) 620 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; cell proliferation [GO:0008283]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of mitotic nuclear division [GO:0007088]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005654; GO:0005680; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0007067; GO:0007088; GO:0008283; GO:0031145; GO:0042787; GO:0043161; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q13045 CHOYP_LOC656702.1.1 m.14425 sp FLII_HUMAN 58.685 1278 474 13 17 1250 1 1268 0 1508 FLII_HUMAN reviewed Protein flightless-1 homolog FLII FLIL Homo sapiens (Human) 1269 "actin cytoskeleton organization [GO:0030036]; actin filament severing [GO:0051014]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003779; GO:0005654; GO:0005737; GO:0005815; GO:0005903; GO:0005925; GO:0006351; GO:0006355; GO:0007275; GO:0030036; GO:0051014 0 0 0 PF00626;PF12799;PF13855; Q13136 CHOYP_BRAFLDRAFT_128281.1.1 m.45871 sp LIPA1_HUMAN 57.058 673 231 14 2 644 504 1148 0 696 LIPA1_HUMAN reviewed Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) PPFIA1 LIP1 Homo sapiens (Human) 1202 cell-matrix adhesion [GO:0007160]; glutamate secretion [GO:0014047]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of stress fiber assembly [GO:0051497]; neurotransmitter secretion [GO:0007269]; signal transduction [GO:0007165] GO:0004871; GO:0005737; GO:0005829; GO:0005925; GO:0007160; GO:0007165; GO:0007269; GO:0014047; GO:0048786; GO:0051497; GO:0090005 0 0 0 PF00536;PF07647; Q13136 CHOYP_LIPA1.1.1 m.10892 sp LIPA1_HUMAN 58.447 1172 406 18 1 1115 1 1148 0 1214 LIPA1_HUMAN reviewed Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) PPFIA1 LIP1 Homo sapiens (Human) 1202 cell-matrix adhesion [GO:0007160]; glutamate secretion [GO:0014047]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of stress fiber assembly [GO:0051497]; neurotransmitter secretion [GO:0007269]; signal transduction [GO:0007165] GO:0004871; GO:0005737; GO:0005829; GO:0005925; GO:0007160; GO:0007165; GO:0007269; GO:0014047; GO:0048786; GO:0051497; GO:0090005 0 0 0 PF00536;PF07647; Q13188 CHOYP_LOC100168569.1.2 m.11752 sp STK3_HUMAN 64.887 487 157 6 41 519 11 491 0 628 STK3_HUMAN reviewed Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] STK3 KRS1 MST2 Homo sapiens (Human) 491 apoptotic process [GO:0006915]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation [GO:0008285]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; primitive hemopoiesis [GO:0060215]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; signal transduction [GO:0007165] GO:0000287; GO:0001841; GO:0003157; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006468; GO:0006915; GO:0007165; GO:0007417; GO:0008285; GO:0032092; GO:0035329; GO:0035556; GO:0043065; GO:0043234; GO:0043539; GO:0045600; GO:0046330; GO:0046621; GO:0046983; GO:0050821; GO:0051091; GO:0051897; GO:0060215; GO:0060706; GO:0060800; GO:0090090; GO:0097284; GO:1902043 0 0 0 PF11629;PF00069; Q13188 CHOYP_LOC100168569.2.2 m.24721 sp STK3_HUMAN 62.205 508 157 6 35 534 11 491 0 619 STK3_HUMAN reviewed Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] STK3 KRS1 MST2 Homo sapiens (Human) 491 apoptotic process [GO:0006915]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation [GO:0008285]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; primitive hemopoiesis [GO:0060215]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; signal transduction [GO:0007165] GO:0000287; GO:0001841; GO:0003157; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006468; GO:0006915; GO:0007165; GO:0007417; GO:0008285; GO:0032092; GO:0035329; GO:0035556; GO:0043065; GO:0043234; GO:0043539; GO:0045600; GO:0046330; GO:0046621; GO:0046983; GO:0050821; GO:0051091; GO:0051897; GO:0060215; GO:0060706; GO:0060800; GO:0090090; GO:0097284; GO:1902043 0 0 0 PF11629;PF00069; Q13200 CHOYP_PSMD2.3.3 m.59658 sp PSMD2_HUMAN 71.94 866 237 2 6 871 21 880 0 1295 PSMD2_HUMAN reviewed 26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2) PSMD2 TRAP2 Homo sapiens (Human) 908 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0005634; GO:0005654; GO:0005829; GO:0005838; GO:0006521; GO:0008540; GO:0016020; GO:0022624; GO:0030234; GO:0031145; GO:0033209; GO:0034515; GO:0038061; GO:0038095; GO:0043161; GO:0043488; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070062; GO:0090090; GO:0090263 0 0 0 PF01851; Q13310 CHOYP_PABP4.2.6 m.22635 sp PABP4_HUMAN 75.524 429 100 3 6 432 1 426 0 675 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q13310 CHOYP_PABP4.3.6 m.35371 sp PABP4_HUMAN 68.665 517 140 6 6 513 1 504 0 709 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q13310 CHOYP_PABP4.4.6 m.38167 sp PABP4_HUMAN 63.12 686 189 8 6 680 1 633 0 821 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q13310 CHOYP_PABP4.5.6 m.38921 sp PABP4_HUMAN 67.492 646 186 7 6 640 1 633 0 845 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q13330 CHOYP_MTA1.1.1 m.12640 sp MTA1_HUMAN 57.067 750 222 16 1 709 1 691 0 803 MTA1_HUMAN reviewed Metastasis-associated protein MTA1 MTA1 Homo sapiens (Human) 715 "circadian regulation of gene expression [GO:0032922]; double-strand break repair [GO:0006302]; entrainment of circadian clock by photoperiod [GO:0043153]; locomotor rhythm [GO:0045475]; positive regulation of protein autoubiquitination [GO:1902499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein sumoylation [GO:0016925]; regulation of gene expression, epigenetic [GO:0040029]; regulation of inflammatory response [GO:0050727]; response to ionizing radiation [GO:0010212]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0001046; GO:0001047; GO:0001103; GO:0003682; GO:0003700; GO:0003713; GO:0003714; GO:0004407; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005874; GO:0006302; GO:0006351; GO:0007165; GO:0008270; GO:0010212; GO:0016925; GO:0032496; GO:0032922; GO:0040029; GO:0043153; GO:0043161; GO:0043231; GO:0045475; GO:0050727; GO:1902499 0 0 0 PF01426;PF01448;PF00320;PF00249; Q13367 CHOYP_BRAFLDRAFT_58684.1.1 m.13006 sp AP3B2_HUMAN 57.416 1099 415 16 30 1103 6 1076 0 1182 AP3B2_HUMAN reviewed AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP) AP3B2 Homo sapiens (Human) 1082 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; intracellular protein transport [GO:0006886]; post-Golgi vesicle-mediated transport [GO:0006892] GO:0005215; GO:0005654; GO:0005737; GO:0005794; GO:0006886; GO:0006892; GO:0008089; GO:0030123; GO:0030137; GO:0030665; GO:0048490; GO:1904115 0 0 0 PF01602;PF14796; Q13415 CHOYP_ORC1.1.2 m.17177 sp ORC1_HUMAN 40.437 915 421 22 6 852 3 861 0 550 ORC1_HUMAN reviewed Origin recognition complex subunit 1 (Replication control protein 1) ORC1 ORC1L PARC1 Homo sapiens (Human) 861 DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083] GO:0000082; GO:0000083; GO:0000808; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0005654; GO:0005664; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0006260; GO:0006270; GO:0048661; GO:0070318 0 0 cd08768; PF00004;PF01426;PF09079; Q13423 CHOYP_LOC100633041.1.1 m.35428 sp NNTM_HUMAN 64.576 1084 352 10 10 1066 6 1084 0 1381 NNTM_HUMAN reviewed "NAD(P) transhydrogenase, mitochondrial (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)" NNT Homo sapiens (Human) 1086 cell redox homeostasis [GO:0045454]; NADPH regeneration [GO:0006740]; oxidation-reduction process [GO:0055114]; proton transport [GO:0015992]; reactive oxygen species metabolic process [GO:0072593]; tricarboxylic acid cycle [GO:0006099] GO:0003957; GO:0005739; GO:0005743; GO:0005746; GO:0006099; GO:0006740; GO:0008746; GO:0008750; GO:0015992; GO:0016020; GO:0016021; GO:0045454; GO:0050661; GO:0051287; GO:0055114; GO:0072593 0 0 0 PF01262;PF05222;PF02233;PF12769; Q13459 CHOYP_MYO9.4.5 m.42573 sp MYO9B_HUMAN 45.951 1136 522 16 21 1082 6 1123 0 970 MYO9B_HUMAN reviewed Unconventional myosin-IXb (Unconventional myosin-9b) MYO9B MYR5 Homo sapiens (Human) 2157 actin filament-based movement [GO:0030048]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] GO:0000146; GO:0001726; GO:0003779; GO:0005096; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0005884; GO:0005938; GO:0007266; GO:0008270; GO:0015629; GO:0016020; GO:0016459; GO:0016887; GO:0017048; GO:0030027; GO:0030048; GO:0030898; GO:0035023; GO:0035385; GO:0043531; GO:0048471; GO:0048495; GO:0051056 0 0 0 PF00612;PF00063;PF00788;PF00620; Q13459 CHOYP_MYO9.5.5 m.43139 sp MYO9B_HUMAN 48.123 1039 465 13 1 983 40 1060 0 967 MYO9B_HUMAN reviewed Unconventional myosin-IXb (Unconventional myosin-9b) MYO9B MYR5 Homo sapiens (Human) 2157 actin filament-based movement [GO:0030048]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] GO:0000146; GO:0001726; GO:0003779; GO:0005096; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0005884; GO:0005938; GO:0007266; GO:0008270; GO:0015629; GO:0016020; GO:0016459; GO:0016887; GO:0017048; GO:0030027; GO:0030048; GO:0030898; GO:0035023; GO:0035385; GO:0043531; GO:0048471; GO:0048495; GO:0051056 0 0 0 PF00612;PF00063;PF00788;PF00620; Q13467 CHOYP_LOC100313610.2.2 m.66186 sp FZD5_HUMAN 59.893 561 186 8 27 575 24 557 0 681 FZD5_HUMAN reviewed Frizzled-5 (Fz-5) (hFz5) (FzE5) FZD5 C2orf31 Homo sapiens (Human) 585 "angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; beta-catenin destruction complex disassembly [GO:1904886]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cell maturation [GO:0048469]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye morphogenesis [GO:0048596]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell proliferation [GO:0008285]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic camera-type eye development [GO:0031077]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; regulation of mitophagy [GO:1903146]; Spemann organizer formation [GO:0060061]; synapse assembly [GO:0007416]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]" GO:0000139; GO:0000578; GO:0001525; GO:0001540; GO:0002726; GO:0004930; GO:0005886; GO:0005923; GO:0007223; GO:0007416; GO:0008285; GO:0008595; GO:0009986; GO:0016021; GO:0017147; GO:0019901; GO:0030182; GO:0030669; GO:0031077; GO:0031625; GO:0031901; GO:0032729; GO:0033077; GO:0035567; GO:0042813; GO:0043507; GO:0044332; GO:0045944; GO:0048469; GO:0048471; GO:0048596; GO:0060061; GO:0060070; GO:0060071; GO:0060561; GO:0060670; GO:0060715; GO:0060716; GO:0060718; GO:0060828; GO:0071219; GO:1901382; GO:1903146; GO:1903955; GO:1904886; GO:2000810 0 0 0 PF01534;PF01392; Q13485 CHOYP_SMAD4.1.4 m.9309 sp SMAD4_HUMAN 64.835 546 109 8 1 464 6 550 0 608 SMAD4_HUMAN reviewed Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) SMAD4 DPC4 MADH4 Homo sapiens (Human) 552 "atrioventricular canal development [GO:0036302]; atrioventricular valve formation [GO:0003190]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell proliferation [GO:0008283]; cellular iron ion homeostasis [GO:0006879]; cellular response to BMP stimulus [GO:0071773]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; endocardial cell differentiation [GO:0060956]; endoderm development [GO:0007492]; endothelial cell activation [GO:0042118]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; female gonad morphogenesis [GO:0061040]; formation of anatomical boundary [GO:0048859]; gastrulation with mouth forming second [GO:0001702]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; mesoderm development [GO:0007498]; metanephric mesenchyme morphogenesis [GO:0072133]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell death [GO:0060548]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural crest cell differentiation [GO:0014033]; neuron fate commitment [GO:0048663]; ovarian follicle development [GO:0001541]; palate development [GO:0060021]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell proliferation involved in heart valve morphogenesis [GO:0003251]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of SMAD protein import into nucleus [GO:0060391]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of binding [GO:0051098]; regulation of hair follicle development [GO:0051797]; regulation of transforming growth factor beta2 production [GO:0032909]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to transforming growth factor beta [GO:0071559]; sebaceous gland development [GO:0048733]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; SMAD protein complex assembly [GO:0007183]; SMAD protein signal transduction [GO:0060395]; somatic stem cell population maintenance [GO:0035019]; somite rostral/caudal axis specification [GO:0032525]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]" GO:0000122; GO:0000790; GO:0000978; GO:0000987; GO:0001076; GO:0001077; GO:0001541; GO:0001658; GO:0001666; GO:0001701; GO:0001702; GO:0003190; GO:0003198; GO:0003220; GO:0003251; GO:0003360; GO:0003682; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0006879; GO:0007179; GO:0007183; GO:0007283; GO:0007338; GO:0007411; GO:0007492; GO:0007498; GO:0008283; GO:0008285; GO:0010614; GO:0010718; GO:0010862; GO:0014033; GO:0017015; GO:0030308; GO:0030509; GO:0030511; GO:0030513; GO:0030616; GO:0032444; GO:0032525; GO:0032909; GO:0033686; GO:0035019; GO:0035556; GO:0036302; GO:0042118; GO:0042733; GO:0042802; GO:0042803; GO:0044212; GO:0045892; GO:0045893; GO:0045944; GO:0046872; GO:0046881; GO:0048589; GO:0048663; GO:0048733; GO:0048859; GO:0051098; GO:0051571; GO:0051797; GO:0060021; GO:0060065; GO:0060391; GO:0060395; GO:0060412; GO:0060548; GO:0060956; GO:0061040; GO:0070102; GO:0070373; GO:0070411; GO:0070412; GO:0071141; GO:0071559; GO:0071773; GO:0072133; GO:0072134; GO:0072520; GO:1901522; GO:2000617 0 0 0 PF03165;PF03166; Q13492 CHOYP_LOC654860.3.3 m.63750 sp PICAL_HUMAN 46.921 682 258 18 46 668 1 637 0 552 PICAL_HUMAN reviewed Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) PICALM CALM Homo sapiens (Human) 652 "cargo loading into vesicle [GO:0035459]; cell proliferation [GO:0008283]; clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; endosomal transport [GO:0016197]; iron ion homeostasis [GO:0055072]; iron ion import into cell [GO:0097459]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of beta-amyloid formation [GO:1902004]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription, DNA-templated [GO:0045893]; protein complex assembly [GO:0006461]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; synaptic vesicle maturation [GO:0016188]; vesicle-mediated transport [GO:0016192]" GO:0005545; GO:0005634; GO:0005794; GO:0005905; GO:0005913; GO:0006461; GO:0006898; GO:0008283; GO:0010629; GO:0016020; GO:0016188; GO:0016192; GO:0016197; GO:0030100; GO:0030136; GO:0030276; GO:0031623; GO:0031982; GO:0032050; GO:0032880; GO:0035459; GO:0035615; GO:0042734; GO:0043025; GO:0045211; GO:0045893; GO:0048261; GO:0048268; GO:0055072; GO:0072583; GO:0097418; GO:0097459; GO:0098641; GO:1901216; GO:1902004; GO:1902959; GO:1902961; GO:1902963 0 0 0 PF07651; Q13591 CHOYP_SEM5B.1.1 m.55903 sp SEM5A_HUMAN 40.772 959 513 21 65 996 60 990 0 720 SEM5A_HUMAN reviewed Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) 1074 axonal fasciculation [GO:0007413]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell chemotaxis [GO:0060326]; diencephalon development [GO:0021536]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of endothelial cell apoptotic process [GO:2000352]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive chemotaxis [GO:0050918]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein kinase B signaling [GO:0051897]; semaphorin-plexin signaling pathway [GO:0071526]; signal clustering [GO:1990256] GO:0001755; GO:0001938; GO:0002043; GO:0005886; GO:0007155; GO:0007162; GO:0007267; GO:0007399; GO:0007413; GO:0016020; GO:0016021; GO:0021536; GO:0030215; GO:0030335; GO:0030836; GO:0035373; GO:0035413; GO:0043395; GO:0045499; GO:0045545; GO:0045766; GO:0048842; GO:0048843; GO:0050918; GO:0051897; GO:0060326; GO:0070062; GO:0071526; GO:1990256; GO:2000352; GO:2001028 0 0 0 PF01403;PF00090; Q13619 CHOYP_CUL4B.1.1 m.6652 sp CUL4A_HUMAN 70.959 761 212 3 51 807 4 759 0 1112 CUL4A_HUMAN reviewed Cullin-4A (CUL-4A) CUL4A Homo sapiens (Human) 759 "cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; DNA damage response, detection of DNA damage [GO:0042769]; G1/S transition of mitotic cell cycle [GO:0000082]; global genome nucleotide-excision repair [GO:0070911]; hemopoiesis [GO:0030097]; intrinsic apoptotic signaling pathway [GO:0097193]; in utero embryonic development [GO:0001701]; negative regulation of cell proliferation [GO:0008285]; negative regulation of granulocyte differentiation [GO:0030853]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of DNA damage checkpoint [GO:2000001]; regulation of nucleotide-excision repair [GO:2000819]; regulation of protein metabolic process [GO:0051246]; somatic stem cell population maintenance [GO:0035019]; transcription-coupled nucleotide-excision repair [GO:0006283]; viral process [GO:0016032]" GO:0000082; GO:0000715; GO:0000717; GO:0001701; GO:0005654; GO:0006283; GO:0006293; GO:0006294; GO:0006295; GO:0006296; GO:0006974; GO:0007050; GO:0008284; GO:0008285; GO:0016032; GO:0030097; GO:0030853; GO:0031464; GO:0031625; GO:0033683; GO:0035019; GO:0042769; GO:0042787; GO:0043161; GO:0051246; GO:0070911; GO:0080008; GO:0097193; GO:1900087; GO:2000001; GO:2000819 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00888;PF10557; Q13867 CHOYP_BLMH.1.1 m.66065 sp BLMH_HUMAN 55.088 452 199 2 31 479 5 455 0 535 BLMH_HUMAN reviewed Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40) BLMH Homo sapiens (Human) 455 protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; response to drug [GO:0042493]; response to toxic substance [GO:0009636] GO:0000209; GO:0004177; GO:0004180; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0008234; GO:0009636; GO:0042493; GO:0070062 0 0 cd00585; PF03051; Q13948 CHOYP_LOC100313569.1.1 m.15201 sp CASP_HUMAN 57.206 680 266 6 1 670 1 665 0 748 CASP_HUMAN reviewed Protein CASP CUX1 CUTL1 Homo sapiens (Human) 678 intra-Golgi vesicle-mediated transport [GO:0006891] GO:0000139; GO:0005654; GO:0005794; GO:0006891; GO:0030173 0 0 0 PF08172; Q14008 CHOYP_CKAP5.1.1 m.10679 sp CKAP5_HUMAN 47.236 2062 985 28 1 1993 1 2028 0 1810 CKAP5_HUMAN reviewed Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG) CKAP5 KIAA0097 Homo sapiens (Human) 2032 cell division [GO:0051301]; centrosome organization [GO:0051297]; establishment or maintenance of microtubule cytoskeleton polarity [GO:0030951]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; RNA transport [GO:0050658]; sister chromatid cohesion [GO:0007062]; spindle organization [GO:0007051] GO:0000086; GO:0000922; GO:0005813; GO:0005829; GO:0005913; GO:0007051; GO:0007062; GO:0007067; GO:0016020; GO:0030951; GO:0043234; GO:0050658; GO:0051297; GO:0051301; GO:0098641 0 0 0 PF12348; Q14117 CHOYP_LOC100372131.1.2 m.36461 sp DPYS_HUMAN 68.34 518 156 2 110 619 2 519 0 751 DPYS_HUMAN reviewed Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) DPYS Homo sapiens (Human) 519 beta-alanine metabolic process [GO:0019482]; protein homotetramerization [GO:0051289]; pyrimidine nucleobase catabolic process [GO:0006208]; pyrimidine nucleoside catabolic process [GO:0046135]; thymine catabolic process [GO:0006210]; uracil catabolic process [GO:0006212] GO:0002058; GO:0002059; GO:0004157; GO:0005829; GO:0006208; GO:0006210; GO:0006212; GO:0008270; GO:0016597; GO:0019482; GO:0046135; GO:0051289; GO:0070062 0 0 cd01314; PF01979; Q14185 CHOYP_DOCK1.2.2 m.61345 sp DOCK1_HUMAN 48.65 1667 797 26 2 1646 4 1633 0 1561 DOCK1_HUMAN reviewed Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) DOCK1 Homo sapiens (Human) 1865 "apoptotic process [GO:0006915]; blood coagulation [GO:0007596]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; integrin-mediated signaling pathway [GO:0007229]; phagocytosis, engulfment [GO:0006911]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]" GO:0005089; GO:0005096; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006911; GO:0006915; GO:0007010; GO:0007165; GO:0007229; GO:0007264; GO:0007596; GO:0010634; GO:0016020; GO:0016477; GO:0032045; GO:0038096; GO:0048010; GO:1900026 0 0 0 PF06920;PF14429;PF16172;PF14604; Q14203 CHOYP_DCTN1.2.2 m.40900 sp DCTN1_HUMAN 43.58 1324 656 19 2 1302 22 1277 0 1003 DCTN1_HUMAN reviewed Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) DCTN1 Homo sapiens (Human) 1278 "antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of localization by movement along microtubule [GO:0010970]; G2/M transition of mitotic cell cycle [GO:0000086]; IRE1-mediated unfolded protein response [GO:0036498]; melanosome transport [GO:0032402]; mitotic nuclear division [GO:0007067]; nervous system development [GO:0007399]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000086; GO:0000776; GO:0000922; GO:0003774; GO:0005737; GO:0005813; GO:0005829; GO:0005869; GO:0005874; GO:0006888; GO:0007067; GO:0007399; GO:0010970; GO:0016020; GO:0019886; GO:0030286; GO:0031252; GO:0032402; GO:0036498; GO:0042147 0 0 0 PF01302;PF12455; Q14204 CHOYP_DYHC1.1.1 m.2432 sp DYHC1_HUMAN 72.34 4653 1250 21 10 4647 16 4646 0 7099 DYHC1_HUMAN reviewed "Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)" DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325 Homo sapiens (Human) 4646 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cytoplasmic mRNA processing body assembly [GO:0033962]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of spindle localization [GO:0051293]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule-based movement [GO:0007018]; mitotic spindle organization [GO:0007052]; stress granule assembly [GO:0034063] GO:0000086; GO:0003777; GO:0005524; GO:0005813; GO:0005829; GO:0005868; GO:0005874; GO:0006888; GO:0007018; GO:0007052; GO:0016020; GO:0016887; GO:0019886; GO:0030175; GO:0031012; GO:0033962; GO:0034063; GO:0044822; GO:0051293; GO:0051959; GO:0070062 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q14247 CHOYP_CTTN.1.1 m.22042 sp SRC8_HUMAN 55.044 565 211 9 1 537 1 550 0 590 SRC8_HUMAN reviewed Src substrate cortactin (Amplaxin) (Oncogene EMS1) CTTN EMS1 Homo sapiens (Human) 550 "actin cytoskeleton reorganization [GO:0031532]; actin filament polymerization [GO:0030041]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of mitophagy [GO:1903146]; substrate-dependent cell migration, cell extension [GO:0006930]" GO:0001726; GO:0002102; GO:0005522; GO:0005737; GO:0005794; GO:0005856; GO:0005886; GO:0005905; GO:0005913; GO:0005925; GO:0005938; GO:0006886; GO:0006898; GO:0006930; GO:0008076; GO:0030027; GO:0030041; GO:0030516; GO:0030838; GO:0030863; GO:0031532; GO:0043197; GO:0043231; GO:0045987; GO:0048041; GO:0048812; GO:0048870; GO:0070062; GO:0097062; GO:0097581; GO:0098641; GO:1903146; GO:1990023; GO:2001237 0 0 0 PF02218;PF14604; Q14432 CHOYP_PDE3A.3.3 m.64400 sp PDE3A_HUMAN 40.038 1039 501 32 99 1077 136 1112 0 602 PDE3A_HUMAN reviewed "cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)" PDE3A Homo sapiens (Human) 1141 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP-mediated signaling [GO:0019934]; diterpenoid metabolic process [GO:0016101]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of vascular permeability [GO:0043116]; oocyte maturation [GO:0001556]; positive regulation of oocyte development [GO:0060282]; positive regulation of vascular permeability [GO:0043117]; regulation of meiotic nuclear division [GO:0040020]; response to cAMP [GO:0051591]; response to drug [GO:0042493] GO:0001556; GO:0004115; GO:0004119; GO:0005829; GO:0006198; GO:0006629; GO:0016021; GO:0016101; GO:0019933; GO:0019934; GO:0030552; GO:0040020; GO:0042493; GO:0043066; GO:0043116; GO:0043117; GO:0046872; GO:0047555; GO:0051591; GO:0060282; GO:0071321; GO:0071560 0 0 0 PF00233; Q14517 CHOYP_LOC100740873.1.1 m.46472 sp FAT1_HUMAN 36.971 4728 2723 86 32 4672 25 4582 0 2767 FAT1_HUMAN reviewed "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; single organismal cell-cell adhesion [GO:0016337] GO:0005509; GO:0005634; GO:0005886; GO:0005887; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016337; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q14527 CHOYP_HLTF.1.1 m.6493 sp HLTF_HUMAN 55.422 581 240 6 830 1407 445 1009 0 696 HLTF_HUMAN reviewed Helicase-like transcription factor (EC 3.6.4.-) (EC 6.3.2.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) HLTF HIP116A RNF80 SMARCA3 SNF2L3 ZBU1 Homo sapiens (Human) 1009 "covalent chromatin modification [GO:0016569]; postreplication repair [GO:0006301]; protein polyubiquitination [GO:0000209]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000209; GO:0000978; GO:0001077; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006301; GO:0006355; GO:0008270; GO:0016020; GO:0016569; GO:0016874; GO:0016887; GO:0031625; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00271;PF08797;PF00176; Q14562 CHOYP_DHX8.2.3 m.55112 sp DHX8_HUMAN 73.065 1240 272 11 2 1219 20 1219 0 1793 DHX8_HUMAN reviewed ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) DHX8 DDX8 Homo sapiens (Human) 1220 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" GO:0000398; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006396; GO:0008380; GO:0042802; GO:0044822; GO:0071013 0 0 0 PF04408;PF00271;PF07717;PF00575; Q14562 CHOYP_DHX8.3.3 m.65324 sp DHX8_HUMAN 89.572 537 56 0 1 537 683 1219 0 1037 DHX8_HUMAN reviewed ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) DHX8 DDX8 Homo sapiens (Human) 1220 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]" GO:0000398; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006396; GO:0008380; GO:0042802; GO:0044822; GO:0071013 0 0 0 PF04408;PF00271;PF07717;PF00575; Q14565 CHOYP_DMC1.1.1 m.49439 sp DMC1_HUMAN 84.071 339 53 1 4 342 3 340 0 598 DMC1_HUMAN reviewed Meiotic recombination protein DMC1/LIM15 homolog DMC1 DMC1H LIM15 Homo sapiens (Human) 340 chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA recombinase assembly [GO:0000730]; female gamete generation [GO:0007292]; male meiosis I [GO:0007141]; meiotic nuclear division [GO:0007126]; mitotic recombination [GO:0006312]; oocyte maturation [GO:0001556]; ovarian follicle development [GO:0001541]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; strand invasion [GO:0042148]; synapsis [GO:0007129] GO:0000150; GO:0000400; GO:0000730; GO:0000781; GO:0000794; GO:0001541; GO:0001556; GO:0003677; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0006312; GO:0007126; GO:0007129; GO:0007131; GO:0007141; GO:0007283; GO:0007286; GO:0007292; GO:0008094; GO:0010212; GO:0042148; GO:0070192 0 0 0 PF08423; Q14643 CHOYP_LOC100533406.2.2 m.51452 sp ITPR1_HUMAN 59.824 2835 907 42 3 2701 6 2744 0 3251 ITPR1_HUMAN reviewed "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 INSP3R1 Homo sapiens (Human) 2758 calcium ion transport [GO:0006816]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; epithelial fluid transport [GO:0042045]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of calcium-mediated signaling [GO:0050849]; platelet activation [GO:0030168]; post-embryonic development [GO:0009791]; regulation of autophagy [GO:0010506]; regulation of cardiac conduction [GO:1903779]; regulation of insulin secretion [GO:0050796]; release of sequestered calcium ion into cytosol [GO:0051209]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; voluntary musculoskeletal movement [GO:0050882] GO:0001666; GO:0005220; GO:0005637; GO:0005730; GO:0005783; GO:0005789; GO:0005955; GO:0006816; GO:0007165; GO:0009791; GO:0010506; GO:0014069; GO:0015085; GO:0015278; GO:0016020; GO:0016021; GO:0016529; GO:0019855; GO:0030168; GO:0031088; GO:0031094; GO:0031095; GO:0032469; GO:0035091; GO:0042045; GO:0050796; GO:0050849; GO:0050882; GO:0051209; GO:0070059; GO:1903779 0 0 0 PF08709;PF00520;PF02815;PF08454;PF01365; Q14667 CHOYP_LOC100165500.1.1 m.24129 sp K0100_HUMAN 33.231 2287 1325 53 16 2177 24 2233 0 1140 K0100_HUMAN reviewed Protein KIAA0100 (Antigen MLAA-22) (Breast cancer-overexpressed gene 1 protein) KIAA0100 BCOX1 Homo sapiens (Human) 2235 0 GO:0005576 0 0 0 PF10351;PF10344;PF10347; Q14692 CHOYP_BMS1.1.1 m.17619 sp BMS1_HUMAN 62.385 436 150 3 3 428 2 433 0 585 BMS1_HUMAN reviewed Ribosome biogenesis protein BMS1 homolog (Ribosome assembly protein BMS1 homolog) BMS1 BMS1L KIAA0187 Homo sapiens (Human) 1282 "endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000479]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosome assembly [GO:0042255]; rRNA processing [GO:0006364]" GO:0000462; GO:0000479; GO:0003924; GO:0005524; GO:0005525; GO:0005634; GO:0005654; GO:0005730; GO:0006364; GO:0030686; GO:0034511; GO:0042255; GO:0044822 0 0 0 PF08142;PF04950; Q14697 CHOYP_LOC100492576.1.1 m.7775 sp GANAB_HUMAN 52.878 938 426 6 32 962 16 944 0 1058 GANAB_HUMAN reviewed Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) GANAB G2AN KIAA0088 Homo sapiens (Human) 944 carbohydrate metabolic process [GO:0005975]; protein folding [GO:0006457] GO:0005788; GO:0005794; GO:0005975; GO:0006457; GO:0016020; GO:0017177; GO:0030246; GO:0031012; GO:0033919; GO:0042470; GO:0044822; GO:0070062 PATHWAY: Glycan metabolism; N-glycan metabolism. 0 0 PF13802;PF01055; Q14703 CHOYP_MBTP1.1.1 m.49020 sp MBTP1_HUMAN 63.671 1057 349 12 25 1066 16 1052 0 1395 MBTP1_HUMAN reviewed Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1) MBTPS1 KIAA0091 S1P SKI1 Homo sapiens (Human) 1052 ATF6-mediated unfolded protein response [GO:0036500]; cholesterol metabolic process [GO:0008203]; lysosome organization [GO:0007040]; membrane protein intracellular domain proteolysis [GO:0031293]; proteolysis [GO:0006508]; regulation of transcription factor import into nucleus [GO:0042990]; response to endoplasmic reticulum stress [GO:0034976] GO:0000139; GO:0004252; GO:0005788; GO:0005789; GO:0005795; GO:0006508; GO:0007040; GO:0008203; GO:0016021; GO:0031293; GO:0034976; GO:0036500; GO:0042990 0 0 0 PF00082; Q14738 CHOYP_2A5D.2.3 m.32240 sp 2A5D_HUMAN 70.99 586 122 4 2 539 16 601 0 838 2A5D_HUMAN reviewed Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) PPP2R5D Homo sapiens (Human) 602 nervous system development [GO:0007399]; signal transduction [GO:0007165] GO:0000159; GO:0004722; GO:0005634; GO:0005654; GO:0005829; GO:0007165; GO:0007399; GO:0008601 0 0 0 PF01603; Q14738 CHOYP_2A5D.3.3 m.37716 sp 2A5D_HUMAN 71.501 593 146 6 438 1015 17 601 0 852 2A5D_HUMAN reviewed Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) PPP2R5D Homo sapiens (Human) 602 nervous system development [GO:0007399]; signal transduction [GO:0007165] GO:0000159; GO:0004722; GO:0005634; GO:0005654; GO:0005829; GO:0007165; GO:0007399; GO:0008601 0 0 0 PF01603; Q14746 CHOYP_COG2.1.2 m.12604 sp COG2_HUMAN 45.479 741 377 11 11 735 8 737 0 627 COG2_HUMAN reviewed Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) COG2 LDLC Homo sapiens (Human) 738 ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891] GO:0000139; GO:0005795; GO:0005829; GO:0006888; GO:0006891; GO:0007030; GO:0008565; GO:0017119; GO:0032588 0 0 0 PF06148;PF12022; Q14746 CHOYP_COG2.2.2 m.62723 sp COG2_HUMAN 45.332 739 377 11 11 733 8 735 0 623 COG2_HUMAN reviewed Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) COG2 LDLC Homo sapiens (Human) 738 ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891] GO:0000139; GO:0005795; GO:0005829; GO:0006888; GO:0006891; GO:0007030; GO:0008565; GO:0017119; GO:0032588 0 0 0 PF06148;PF12022; Q14839 CHOYP_CHD5.1.2 m.18511 sp CHD4_HUMAN 66.376 1148 321 18 1 1134 449 1545 0 1506 CHD4_HUMAN reviewed Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta) CHD4 Homo sapiens (Human) 1912 "ATP-dependent chromatin remodeling [GO:0043044]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spindle assembly [GO:0051225]; terminal button organization [GO:0072553]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0001103; GO:0003677; GO:0004003; GO:0004407; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006351; GO:0006357; GO:0008270; GO:0016020; GO:0016581; GO:0032993; GO:0043044; GO:0043234; GO:0051225; GO:0072553; GO:1901796 0 0 0 PF08074;PF08073;PF00385;PF06461;PF06465;PF00271;PF00628;PF00176; Q148G5 CHOYP_LOC101078914.1.1 m.34199 sp PROD_BOVIN 49.502 602 277 8 27 619 9 592 0 592 PROD_BOVIN reviewed "Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase)" PRODH Bos taurus (Bovine) 593 proline catabolic process to glutamate [GO:0010133] GO:0004657; GO:0005759; GO:0010133; GO:0071949 PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2. {ECO:0000250|UniProtKB:O43272}. 0 0 PF01619; Q14974 CHOYP_LOC100533387.1.1 m.56131 sp IMB1_HUMAN 72.748 877 235 2 1 876 1 874 0 1320 IMB1_HUMAN reviewed Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) KPNB1 NTF97 Homo sapiens (Human) 876 "apoptotic DNA fragmentation [GO:0006309]; astral microtubule organization [GO:0030953]; establishment of mitotic spindle localization [GO:0040001]; establishment of protein localization [GO:0045184]; intracellular transport of virus [GO:0075733]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; modulation by virus of host process [GO:0019054]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus [GO:0006606]; protein import into nucleus, docking [GO:0000059]; protein import into nucleus, translocation [GO:0000060]; Ran protein signal transduction [GO:0031291]; ribosomal protein import into nucleus [GO:0006610]" GO:0000059; GO:0000060; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005829; GO:0006309; GO:0006606; GO:0006607; GO:0006610; GO:0007079; GO:0007080; GO:0008139; GO:0008270; GO:0008565; GO:0016020; GO:0019054; GO:0019899; GO:0019904; GO:0030953; GO:0031291; GO:0031965; GO:0034399; GO:0040001; GO:0043234; GO:0044822; GO:0045184; GO:0070062; GO:0071782; GO:0075733; GO:0090307 0 0 0 PF03810; Q149N8 CHOYP_SHPRH.1.3 m.6797 sp SHPRH_HUMAN 50.629 1033 488 7 125 1145 659 1681 0 1085 SHPRH_HUMAN reviewed "E3 ubiquitin-protein ligase SHPRH (EC 3.6.4.-) (EC 6.3.2.-) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)" SHPRH KIAA2023 Homo sapiens (Human) 1683 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0000786; GO:0003677; GO:0004386; GO:0004842; GO:0005524; GO:0005634; GO:0006281; GO:0006334; GO:0006974; GO:0008270; GO:0016874; GO:0031625 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00271;PF00538;PF00176; Q14AT5 CHOYP_LOC100906981.1.1 m.55719 sp ANO7_MOUSE 54.345 817 353 6 63 870 49 854 0 918 ANO7_MOUSE reviewed Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G) Ano7 Ngep Tmem16g Mus musculus (Mouse) 859 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transport [GO:0006821] GO:0005229; GO:0005622; GO:0005634; GO:0005783; GO:0005886; GO:0006821; GO:0016021; GO:0017128; GO:0061589; GO:0061590; GO:0061591 0 0 0 PF16178;PF04547; Q14CX7 CHOYP_NAA25.1.1 m.11255 sp NAA25_HUMAN 39.369 983 573 12 4 974 1 972 0 691 NAA25_HUMAN reviewed "N-alpha-acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N-terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N-terminal acetyltransferase B complex subunit NAA25) (p120)" NAA25 C12orf30 MDM20 NAP1 Homo sapiens (Human) 972 N-terminal peptidyl-methionine acetylation [GO:0017196] GO:0005654; GO:0005737; GO:0005794; GO:0017196; GO:0031416 0 0 0 PF09797; Q15008 CHOYP_PSMD6.1.1 m.60839 sp PSMD6_HUMAN 71.465 389 111 0 16 404 1 389 0 587 PSMD6_HUMAN reviewed 26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A) PSMD6 KIAA0107 PFAAP4 Homo sapiens (Human) 389 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0005654; GO:0005829; GO:0005838; GO:0006508; GO:0006521; GO:0016887; GO:0022624; GO:0031145; GO:0033209; GO:0038061; GO:0038095; GO:0043161; GO:0043488; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070062; GO:0090090; GO:0090263 0 0 0 PF01399;PF10602; Q15029 CHOYP_U5S1.1.1 m.49230 sp U5S1_HUMAN 81.089 973 183 1 1 973 1 972 0 1615 U5S1_HUMAN reviewed "116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)" EFTUD2 KIAA0031 SNRP116 Homo sapiens (Human) 972 "cellular response to drug [GO:0035690]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; response to cocaine [GO:0042220]; RNA splicing [GO:0008380]" GO:0000398; GO:0003924; GO:0005525; GO:0005654; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0015030; GO:0016020; GO:0016607; GO:0031012; GO:0035690; GO:0042220; GO:0044822; GO:0071013 0 0 0 PF00679;PF14492;PF03764;PF16004;PF03144; Q15058 CHOYP_LOC100371468.1.2 m.16646 sp KIF14_HUMAN 42.236 1288 615 20 175 1399 321 1542 0 910 KIF14_HUMAN reviewed Kinesin-like protein KIF14 KIF14 KIAA0042 Homo sapiens (Human) 1648 activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; cytoskeleton-dependent intracellular transport [GO:0030705]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic cell cycle process [GO:1903047]; mitotic metaphase plate congression [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0001558; GO:0003777; GO:0005524; GO:0005634; GO:0005829; GO:0005871; GO:0005874; GO:0007018; GO:0007080; GO:0008017; GO:0008284; GO:0008574; GO:0010389; GO:0015631; GO:0016020; GO:0016887; GO:0019901; GO:0021685; GO:0021693; GO:0021695; GO:0021766; GO:0021772; GO:0021846; GO:0021987; GO:0030155; GO:0030165; GO:0030334; GO:0030496; GO:0030705; GO:0031146; GO:0031641; GO:0032147; GO:0032467; GO:0032487; GO:0033624; GO:0034446; GO:0043066; GO:0043161; GO:0043523; GO:0043524; GO:0045184; GO:0051233; GO:0051301; GO:1903047; GO:1903429; GO:2000045 0 0 0 PF00498;PF00225;PF16183; Q15058 CHOYP_LOC100371468.2.2 m.53875 sp KIF14_HUMAN 50.054 921 393 12 26 924 355 1230 0 854 KIF14_HUMAN reviewed Kinesin-like protein KIF14 KIF14 KIAA0042 Homo sapiens (Human) 1648 activation of protein kinase activity [GO:0032147]; cell division [GO:0051301]; cell proliferation in forebrain [GO:0021846]; cerebellar cortex development [GO:0021695]; cerebellar granular layer structural organization [GO:0021685]; cerebellar Purkinje cell layer structural organization [GO:0021693]; cerebral cortex development [GO:0021987]; cytoskeleton-dependent intracellular transport [GO:0030705]; establishment of protein localization [GO:0045184]; hippocampus development [GO:0021766]; microtubule-based movement [GO:0007018]; mitotic cell cycle process [GO:1903047]; mitotic metaphase plate congression [GO:0007080]; negative regulation of apoptotic process [GO:0043066]; negative regulation of integrin activation [GO:0033624]; negative regulation of neuron apoptotic process [GO:0043524]; olfactory bulb development [GO:0021772]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of cell growth [GO:0001558]; regulation of cell maturation [GO:1903429]; regulation of cell migration [GO:0030334]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of myelination [GO:0031641]; regulation of neuron apoptotic process [GO:0043523]; regulation of Rap protein signal transduction [GO:0032487]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0001558; GO:0003777; GO:0005524; GO:0005634; GO:0005829; GO:0005871; GO:0005874; GO:0007018; GO:0007080; GO:0008017; GO:0008284; GO:0008574; GO:0010389; GO:0015631; GO:0016020; GO:0016887; GO:0019901; GO:0021685; GO:0021693; GO:0021695; GO:0021766; GO:0021772; GO:0021846; GO:0021987; GO:0030155; GO:0030165; GO:0030334; GO:0030496; GO:0030705; GO:0031146; GO:0031641; GO:0032147; GO:0032467; GO:0032487; GO:0033624; GO:0034446; GO:0043066; GO:0043161; GO:0043523; GO:0043524; GO:0045184; GO:0051233; GO:0051301; GO:1903047; GO:1903429; GO:2000045 0 0 0 PF00498;PF00225;PF16183; Q15147 CHOYP_PLCB4.1.2 m.1637 sp PLCB4_HUMAN 57.882 1199 450 12 1 1168 1 1175 0 1377 PLCB4_HUMAN reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)" PLCB4 Homo sapiens (Human) 1175 inositol phosphate metabolic process [GO:0043647]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; negative regulation of potassium ion transport [GO:0043267] GO:0004435; GO:0004629; GO:0004871; GO:0005509; GO:0005634; GO:0005790; GO:0005829; GO:0014069; GO:0016042; GO:0030425; GO:0035556; GO:0043267; GO:0043647 0 0 0 PF00168;PF06631;PF09279;PF00388;PF00387; Q15155 CHOYP_NOMO1.2.2 m.46404 sp NOMO1_HUMAN 45.7 1186 594 9 39 1179 34 1214 0 1076 NOMO1_HUMAN reviewed Nodal modulator 1 (pM5 protein) NOMO1 PM5 Homo sapiens (Human) 1222 0 GO:0016020; GO:0016021; GO:0030246 0 0 0 0 Q15291 CHOYP_BRAFLDRAFT_203393.1.2 m.16760 sp RBBP5_HUMAN 68.813 497 148 4 1 491 1 496 0 720 RBBP5_HUMAN reviewed Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) RBBP5 RBQ3 Homo sapiens (Human) 538 "beta-catenin-TCF complex assembly [GO:1904837]; cellular response to DNA damage stimulus [GO:0006974]; histone H3-K4 methylation [GO:0051568]; regulation of transcription, DNA-templated [GO:0006355]; response to estrogen [GO:0043627]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0006974; GO:0018024; GO:0035064; GO:0035097; GO:0043627; GO:0044212; GO:0044666; GO:0048188; GO:0051568; GO:0071339; GO:1904837 0 0 0 PF00400; Q15291 CHOYP_BRAFLDRAFT_203393.2.2 m.37719 sp RBBP5_HUMAN 68.813 497 148 4 1 491 1 496 0 723 RBBP5_HUMAN reviewed Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) RBBP5 RBQ3 Homo sapiens (Human) 538 "beta-catenin-TCF complex assembly [GO:1904837]; cellular response to DNA damage stimulus [GO:0006974]; histone H3-K4 methylation [GO:0051568]; regulation of transcription, DNA-templated [GO:0006355]; response to estrogen [GO:0043627]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0006974; GO:0018024; GO:0035064; GO:0035097; GO:0043627; GO:0044212; GO:0044666; GO:0048188; GO:0051568; GO:0071339; GO:1904837 0 0 0 PF00400; Q15392 CHOYP_DHCR24.1.1 m.57301 sp DHC24_HUMAN 61.614 508 193 2 17 523 9 515 0 693 DHC24_HUMAN reviewed Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) DHCR24 KIAA0018 Homo sapiens (Human) 516 amyloid precursor protein catabolic process [GO:0042987]; apoptotic process [GO:0006915]; cell cycle arrest [GO:0007050]; cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; male genitalia development [GO:0030539]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; oxidation-reduction process [GO:0055114]; plasminogen activation [GO:0031639]; protein localization [GO:0008104]; Ras protein signal transduction [GO:0007265]; regulation of neuron death [GO:1901214]; response to hormone [GO:0009725]; response to oxidative stress [GO:0006979]; skin development [GO:0043588]; tissue development [GO:0009888] GO:0000139; GO:0000246; GO:0005634; GO:0005783; GO:0005789; GO:0005829; GO:0005856; GO:0006695; GO:0006915; GO:0006979; GO:0007050; GO:0007265; GO:0008104; GO:0008285; GO:0009725; GO:0009888; GO:0016020; GO:0016021; GO:0016614; GO:0016628; GO:0019899; GO:0030539; GO:0031639; GO:0033489; GO:0033490; GO:0042605; GO:0042987; GO:0043066; GO:0043154; GO:0043588; GO:0050614; GO:0050660; GO:0055114; GO:0061024; GO:1901214 PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. 0 0 PF01565; Q15393 CHOYP_SF3B3.1.1 m.45473 sp SF3B3_HUMAN 83.155 1217 205 0 1 1217 1 1217 0 2142 SF3B3_HUMAN reviewed Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130) SF3B3 KIAA0017 SAP130 Homo sapiens (Human) 1217 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]; protein complex assembly [GO:0006461]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005689; GO:0005730; GO:0006397; GO:0006461; GO:0008380; GO:0030532; GO:0042177; GO:0071013 0 0 0 PF03178; Q15438 CHOYP_CYH1.1.1 m.66676 sp CYH1_HUMAN 72.165 388 103 3 11 395 10 395 0 587 CYH1_HUMAN reviewed "Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1)" CYTH1 D17S811E PSCD1 Homo sapiens (Human) 398 regulation of ARF protein signal transduction [GO:0032012]; regulation of cell adhesion [GO:0030155]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0005086; GO:0005737; GO:0005829; GO:0005886; GO:0008289; GO:0016192; GO:0030155; GO:0031234; GO:0032012 0 0 0 PF00169;PF01369; Q15459 CHOYP_SF3A1.1.3 m.41531 sp SF3A1_HUMAN 63.419 544 166 9 17 547 27 550 0 608 SF3A1_HUMAN reviewed Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) SF3A1 SAP114 Homo sapiens (Human) 793 "mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000381; GO:0000389; GO:0000398; GO:0003723; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0006397; GO:0044822; GO:0071004; GO:0071013 0 0 0 PF12230;PF01805;PF00240; Q15477 CHOYP_SKIV2L.3.4 m.25390 sp SKIV2_HUMAN 54.206 963 430 7 86 1042 289 1246 0 1044 SKIV2_HUMAN reviewed Helicase SKI2W (Ski2) (EC 3.6.4.-) (Helicase-like protein) (HLP) SKIV2L DDX13 SKI2W SKIV2 W Homo sapiens (Human) 1246 RNA catabolic process [GO:0006401] GO:0003723; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0006401; GO:0055087 0 0 0 PF00270;PF08148;PF00271;PF13234; Q15477 CHOYP_SKIV2L.4.4 m.46944 sp SKIV2_HUMAN 52.339 1240 556 16 14 1234 23 1246 0 1256 SKIV2_HUMAN reviewed Helicase SKI2W (Ski2) (EC 3.6.4.-) (Helicase-like protein) (HLP) SKIV2L DDX13 SKI2W SKIV2 W Homo sapiens (Human) 1246 RNA catabolic process [GO:0006401] GO:0003723; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0006401; GO:0055087 0 0 0 PF00270;PF08148;PF00271;PF13234; Q15542 CHOYP_LOC101175542.1.1 m.39653 sp TAF5_HUMAN 58.512 605 245 3 87 687 193 795 0 754 TAF5_HUMAN reviewed Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100) TAF5 TAF2D Homo sapiens (Human) 800 "chromatin modification [GO:0016568]; DNA-templated transcription, initiation [GO:0006352]; histone acetylation [GO:0016573]; regulation of signal transduction by p53 class mediator [GO:1901796]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]" GO:0003700; GO:0005634; GO:0005654; GO:0005669; GO:0006352; GO:0006366; GO:0006367; GO:0006368; GO:0015629; GO:0016032; GO:0016568; GO:0016573; GO:0033276; GO:0042795; GO:0043231; GO:0044212; GO:0046983; GO:1901796 0 0 cd08044; PF04494;PF00400; Q155U0 CHOYP_VPS51.1.1 m.43266 sp VPS51_DANRE 59.124 822 285 9 9 784 11 827 0 941 VPS51_DANRE reviewed Vacuolar protein sorting-associated protein 51 homolog (Protein fat-free) vps51 ffr Danio rerio (Zebrafish) (Brachydanio rerio) 827 endocytic recycling [GO:0032456]; Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; lipid digestion [GO:0044241]; lipid transport [GO:0006869]; protein transport [GO:0015031]; regulation of phospholipase activity [GO:0010517] GO:0000938; GO:0006869; GO:0007030; GO:0010517; GO:0015031; GO:0030306; GO:0032456; GO:0044241; GO:0048193; GO:0055037; GO:1990745 0 0 0 0 Q15751 CHOYP_HERC1.2.2 m.51367 sp HERC1_HUMAN 50.506 2176 953 31 2725 4831 2740 4860 0 2077 HERC1_HUMAN reviewed Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) HERC1 Homo sapiens (Human) 4861 cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of autophagy [GO:0010507]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; transport [GO:0006810] GO:0004842; GO:0005086; GO:0005737; GO:0005794; GO:0005829; GO:0006810; GO:0010507; GO:0016020; GO:0016874; GO:0021702; GO:0031175; GO:0050885 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632;PF00415;PF00622;PF00400; Q15811 CHOYP_ITSN1.1.4 m.4082 sp ITSN1_HUMAN 57.856 681 253 9 190 863 1066 1719 0 816 ITSN1_HUMAN reviewed Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) 1721 ephrin receptor signaling pathway [GO:0048013]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle endocytosis [GO:0048488] GO:0005085; GO:0005089; GO:0005509; GO:0005829; GO:0005886; GO:0005905; GO:0007264; GO:0019209; GO:0030027; GO:0030054; GO:0030139; GO:0032947; GO:0035023; GO:0043005; GO:0043065; GO:0043524; GO:0045202; GO:0048013; GO:0048488; GO:0051056; GO:0051897; GO:0070064 0 0 0 PF00168;PF12763;PF16652;PF00621;PF00018;PF14604; Q15811 CHOYP_ITSN1.4.4 m.35131 sp ITSN1_HUMAN 42.548 1805 837 35 10 1714 15 1719 0 1305 ITSN1_HUMAN reviewed Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) 1721 ephrin receptor signaling pathway [GO:0048013]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle endocytosis [GO:0048488] GO:0005085; GO:0005089; GO:0005509; GO:0005829; GO:0005886; GO:0005905; GO:0007264; GO:0019209; GO:0030027; GO:0030054; GO:0030139; GO:0032947; GO:0035023; GO:0043005; GO:0043065; GO:0043524; GO:0045202; GO:0048013; GO:0048488; GO:0051056; GO:0051897; GO:0070064 0 0 0 PF00168;PF12763;PF16652;PF00621;PF00018;PF14604; Q15811 CHOYP_ITSN2.1.1 m.48179 sp ITSN1_HUMAN 43.026 1778 816 38 10 1664 15 1718 0 1293 ITSN1_HUMAN reviewed Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) 1721 ephrin receptor signaling pathway [GO:0048013]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle endocytosis [GO:0048488] GO:0005085; GO:0005089; GO:0005509; GO:0005829; GO:0005886; GO:0005905; GO:0007264; GO:0019209; GO:0030027; GO:0030054; GO:0030139; GO:0032947; GO:0035023; GO:0043005; GO:0043065; GO:0043524; GO:0045202; GO:0048013; GO:0048488; GO:0051056; GO:0051897; GO:0070064 0 0 0 PF00168;PF12763;PF16652;PF00621;PF00018;PF14604; Q16513 CHOYP_LOC100377872.1.1 m.30372 sp PKN2_HUMAN 56.447 985 372 14 37 1005 41 984 0 1059 PKN2_HUMAN reviewed Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) PKN2 PRK2 PRKCL2 Homo sapiens (Human) 984 "apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0004672; GO:0004674; GO:0004697; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005913; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0007049; GO:0007165; GO:0010631; GO:0016301; GO:0018105; GO:0030027; GO:0030054; GO:0030496; GO:0032154; GO:0032467; GO:0035556; GO:0042826; GO:0043234; GO:0043296; GO:0043297; GO:0044822; GO:0045070; GO:0045111; GO:0045931; GO:0048471; GO:0051301; GO:0070063; GO:0098641; GO:2000145 0 0 0 PF02185;PF00069;PF00433; Q16549 CHOYP_PCSK7.1.1 m.18126 sp PCSK7_HUMAN 53.355 611 272 7 130 732 95 700 0 626 PCSK7_HUMAN reviewed Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21.-) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7) PCSK7 LPC PC7 PC8 SPC7 Homo sapiens (Human) 785 peptide hormone processing [GO:0016486]; protein processing [GO:0016485] GO:0004252; GO:0008233; GO:0016485; GO:0016486; GO:0030173 0 0 0 PF01483;PF00082;PF16470; Q16720 CHOYP_ATP2B3.1.1 m.6573 sp AT2B3_HUMAN 61.358 1149 381 11 14 1147 22 1122 0 1385 AT2B3_HUMAN reviewed Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) ATP2B3 Homo sapiens (Human) 1220 cellular calcium ion homeostasis [GO:0006874]; ion transmembrane transport [GO:0034220]; regulation of cardiac conduction [GO:1903779]; transport [GO:0006810] GO:0005388; GO:0005524; GO:0005794; GO:0005886; GO:0005887; GO:0006810; GO:0006874; GO:0030165; GO:0034220; GO:0043231; GO:0046872; GO:1903561; GO:1903779 0 0 0 PF12424;PF00689;PF00690;PF00122;PF08282; Q16760 CHOYP_DGKD.2.2 m.9520 sp DGKD_HUMAN 56.019 1246 458 23 33 1253 33 1213 0 1310 DGKD_HUMAN reviewed Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) DGKD KIAA0145 Homo sapiens (Human) 1214 cell growth [GO:0016049]; diacylglycerol metabolic process [GO:0046339]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; multicellular organism development [GO:0007275]; platelet activation [GO:0030168]; protein homooligomerization [GO:0051260]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein transport [GO:0015031]; response to organic substance [GO:0010033]; second-messenger-mediated signaling [GO:0019932]; signal transduction [GO:0007165] GO:0004143; GO:0005524; GO:0005737; GO:0005886; GO:0006897; GO:0007165; GO:0007173; GO:0007205; GO:0007275; GO:0010033; GO:0015031; GO:0016023; GO:0016049; GO:0019932; GO:0019992; GO:0030168; GO:0042803; GO:0046339; GO:0046872; GO:0046982; GO:0051260 0 0 0 PF00130;PF00609;PF00781;PF00169;PF07647; Q16956 CHOYP_GRP78.2.5 m.33058 sp GRP78_APLCA 86.749 649 83 2 6 651 7 655 0 1117 GRP78_APLCA reviewed 78 kDa glucose-regulated protein (GRP-78) (BiP) (Protein 1603) 0 Aplysia californica (California sea hare) 667 0 GO:0005524; GO:0005788 0 0 0 PF00012; Q16959 CHOYP_LOC100368022.1.1 m.55588 sp DYI2_HELCR 63.497 715 226 4 36 748 20 701 0 926 DYI2_HELCR reviewed "Dynein intermediate chain 2, ciliary" 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 702 0 GO:0003774; GO:0005737; GO:0005874; GO:0005929; GO:0030286 0 0 0 PF00400; Q16960 CHOYP_LOC100378071.1.1 m.40488 sp DYI3_HELCR 74.177 577 144 2 1 577 1 572 0 912 DYI3_HELCR reviewed "Dynein intermediate chain 3, ciliary" 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 597 0 GO:0003774; GO:0005737; GO:0005874; GO:0005929; GO:0030286 0 0 0 0 Q16974 CHOYP_KPC1.2.2 m.37402 sp KPC1_APLCA 81.106 651 120 2 192 841 1 649 0 1104 KPC1_APLCA reviewed Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I) PRKC1 Aplysia californica (California sea hare) 649 intracellular signal transduction [GO:0035556] GO:0004697; GO:0005524; GO:0005737; GO:0008270; GO:0035556 0 0 0 PF00130;PF00168;PF00069;PF00433; Q16975 CHOYP_KPC2.1.3 m.22368 sp KPC2_APLCA 70.245 736 194 9 4 715 9 743 0 1046 KPC2_APLCA reviewed Calcium-independent protein kinase C (EC 2.7.11.13) (APL II) PRKC2 Aplysia californica (California sea hare) 743 intracellular signal transduction [GO:0035556] GO:0004697; GO:0005524; GO:0005622; GO:0016020; GO:0035556; GO:0046872 0 0 0 PF00130;PF00168;PF00069;PF00433; Q16975 CHOYP_KPC2.3.3 m.64424 sp KPC2_APLCA 67.895 760 202 10 4 746 9 743 0 1031 KPC2_APLCA reviewed Calcium-independent protein kinase C (EC 2.7.11.13) (APL II) PRKC2 Aplysia californica (California sea hare) 743 intracellular signal transduction [GO:0035556] GO:0004697; GO:0005524; GO:0005622; GO:0016020; GO:0035556; GO:0046872 0 0 0 PF00130;PF00168;PF00069;PF00433; Q17BU3 CHOYP_LOC100875479.2.2 m.57644 sp KIF1A_AEDAE 58.233 1743 590 29 20 1723 1 1644 0 1940 KIF1A_AEDAE reviewed Kinesin-like protein unc-104 unc-104 AAEL004812 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 1644 synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005875; GO:0047496; GO:0048489 0 0 0 PF12473;PF00498;PF12423;PF00225;PF16183;PF00169; Q17DK5 CHOYP_CRY1.1.2 m.43656 sp CRY1_AEDAE 50.183 546 240 8 10 535 6 539 0 554 CRY1_AEDAE reviewed Cryptochrome-1 cry AAEL004146 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 545 "negative regulation of transcription, DNA-templated [GO:0045892]; protein-chromophore linkage [GO:0018298]; protein import into nucleus, translocation [GO:0000060]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000060; GO:0005634; GO:0005641; GO:0005737; GO:0006351; GO:0009882; GO:0018298; GO:0042752; GO:0045892; GO:0048471; GO:0048511; GO:0050660 0 0 0 PF00875;PF03441; Q17GZ9 CHOYP_LOC100370071.1.1 m.46123 sp ARP5_AEDAE 43.865 709 322 10 9 708 3 644 0 560 ARP5_AEDAE reviewed Actin-related protein 5 Arp5 AAEL002822 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 655 "chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006281; GO:0006310; GO:0006338; GO:0006351; GO:0006355; GO:0031011 0 0 0 PF00022; Q17LW0 CHOYP_MYO7A.1.3 m.59205 sp MYO7A_AEDAE 67.508 2179 679 13 7 2175 2 2161 0 3053 MYO7A_AEDAE reviewed Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 2163 actin filament-based movement [GO:0030048]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; imaginal disc-derived wing hair organization [GO:0035317]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0008407; GO:0016459; GO:0030048; GO:0030898; GO:0032027; GO:0035317; GO:0048800 0 0 0 PF00373;PF00612;PF00063;PF00784; Q17LW0 CHOYP_MYO7A.2.3 m.63360 sp MYO7A_AEDAE 36.027 1188 689 17 154 1289 990 2158 0 772 MYO7A_AEDAE reviewed Myosin-VIIa (Protein crinkled) ck AAEL001220 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 2163 actin filament-based movement [GO:0030048]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; imaginal disc-derived wing hair organization [GO:0035317]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0008407; GO:0016459; GO:0030048; GO:0030898; GO:0032027; GO:0035317; GO:0048800 0 0 0 PF00373;PF00612;PF00063;PF00784; Q17N71 CHOYP_CLU.1.1 m.8566 sp CLU_AEDAE 61.124 1335 455 14 18 1298 46 1370 0 1688 CLU_AEDAE reviewed Clustered mitochondria protein homolog AAEL000794 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 1442 intracellular distribution of mitochondria [GO:0048312] GO:0005737; GO:0048312 0 0 cd15466; PF13236;PF15044;PF05303;PF12807;PF13374; Q17QZ7 CHOYP_TTC27.1.1 m.30112 sp TTC27_BOVIN 37.53 842 496 7 12 831 9 842 0 573 TTC27_BOVIN reviewed Tetratricopeptide repeat protein 27 (TPR repeat protein 27) TTC27 Bos taurus (Bovine) 847 0 0 0 0 0 PF13181; Q17R09 CHOYP_PRP16.1.1 m.19094 sp PRP16_BOVIN 65.781 1242 392 11 7 1232 3 1227 0 1616 PRP16_BOVIN reviewed Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) DHX38 PRP16 Bos taurus (Bovine) 1227 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0004004; GO:0005524; GO:0005681; GO:0005737; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF07717; Q17R14 CHOYP_LOC373223.1.1 m.48226 sp MYO1D_BOVIN 56.874 1011 422 7 6 1012 4 1004 0 1185 MYO1D_BOVIN reviewed Unconventional myosin-Id MYO1D Bos taurus (Bovine) 1006 cellular localization [GO:0051641]; early endosome to recycling endosome transport [GO:0061502]; negative regulation of phosphatase activity [GO:0010923] GO:0003774; GO:0005516; GO:0005524; GO:0005768; GO:0005829; GO:0005903; GO:0010923; GO:0016323; GO:0016459; GO:0030424; GO:0030898; GO:0031410; GO:0043005; GO:0043025; GO:0043209; GO:0051015; GO:0051641; GO:0061502; GO:0097440 0 0 0 PF00612;PF00063;PF06017; Q18297 CHOYP_LOC593338.1.2 m.31413 sp TRPA1_CAEEL 34.087 1238 687 33 22 1174 3 1196 0 601 TRPA1_CAEEL reviewed Transient receptor potential cation channel subfamily A member 1 homolog trpa-1 C29E6.2 Caenorhabditis elegans 1211 response to stimulus [GO:0050896] GO:0005216; GO:0005886; GO:0016021; GO:0031513; GO:0043025; GO:0050896 0 0 0 PF12796;PF00520; Q18297 CHOYP_LOC593338.2.2 m.41564 sp TRPA1_CAEEL 33.36 1265 687 33 22 1201 3 1196 0 592 TRPA1_CAEEL reviewed Transient receptor potential cation channel subfamily A member 1 homolog trpa-1 C29E6.2 Caenorhabditis elegans 1211 response to stimulus [GO:0050896] GO:0005216; GO:0005886; GO:0016021; GO:0031513; GO:0043025; GO:0050896 0 0 0 PF12796;PF00520; Q19981 CHOYP_LOC100871946.1.1 m.54244 sp TAG53_CAEEL 33.008 1333 700 36 26 1214 30 1313 0 698 TAG53_CAEEL reviewed Putative protein tag-53 tag-53 F33C8.1 Caenorhabditis elegans 1329 0 GO:0016021 0 0 0 PF00431;PF01344;PF00053;PF01437; Q1EG27 CHOYP_MYO3AL.1.1 m.8123 sp MYO3B_MOUSE 44.814 752 378 13 4 727 328 1070 0 620 MYO3B_MOUSE reviewed Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) 1305 peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0000146; GO:0001750; GO:0001917; GO:0004674; GO:0005524; GO:0005737; GO:0007601; GO:0016459; GO:0018105; GO:0018107; GO:0032426; GO:0032433; GO:0046777; GO:0050896; GO:0051491 0 0 0 PF00612;PF00063;PF00069; Q1HE26 CHOYP_SMAD4.2.4 m.10631 sp SMAD4_BOVIN 66.788 548 142 7 1 510 6 551 0 652 SMAD4_BOVIN reviewed Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4) SMAD4 Bos taurus (Bovine) 553 "transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0007179; GO:0046872 0 0 0 PF03165;PF03166; Q1HE26 CHOYP_SMAD4.3.4 m.13408 sp SMAD4_BOVIN 63.543 587 150 9 1 564 6 551 0 652 SMAD4_BOVIN reviewed Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (SMAD family member 4) (SMAD 4) (Smad4) SMAD4 Bos taurus (Bovine) 553 "transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0007179; GO:0046872 0 0 0 PF03165;PF03166; Q1JP63 CHOYP_LOC100375275.1.1 m.51864 sp SVOP_BOVIN 56.262 519 217 5 39 555 13 523 0 590 SVOP_BOVIN reviewed Synaptic vesicle 2-related protein (SV2-related protein) SVOP Bos taurus (Bovine) 548 0 GO:0016021; GO:0022891; GO:0030054; GO:0030672 0 0 cd06174; PF07690;PF00083; Q1JPX3 CHOYP_SYFA.1.1 m.53256 sp SYFA_DANRE 66.867 498 161 3 1 495 1 497 0 702 SYFA_DANRE reviewed Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) farsa farsla zgc:136506 zgc:158185 Danio rerio (Zebrafish) (Brachydanio rerio) 497 phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290] GO:0000049; GO:0004826; GO:0005524; GO:0005737; GO:0006432; GO:0009328; GO:0051290 0 0 0 PF01409; Q1LUT1 CHOYP_LOC100374995.1.3 m.34198 sp EDC4_DANRE 34.086 1373 768 32 81 1387 76 1377 0 688 EDC4_DANRE reviewed Enhancer of mRNA-decapping protein 4 edc4 si:dkey-16n13.6 Danio rerio (Zebrafish) (Brachydanio rerio) 1384 0 GO:0000932; GO:0005634 0 0 0 PF16529; Q1RLX4 CHOYP_BRAFLDRAFT_87429.1.1 m.43808 sp TPC11_DANRE 53.381 1124 502 12 6 1114 7 1123 0 1181 TPC11_DANRE reviewed Trafficking protein particle complex subunit 11 (Protein foie gras) trappc11 fgr foigr zgc:136723 zgc:63684 Danio rerio (Zebrafish) (Brachydanio rerio) 1132 liver development [GO:0001889]; retina development in camera-type eye [GO:0060041]; vesicle-mediated transport [GO:0016192] GO:0001889; GO:0005794; GO:0016192; GO:0060041 0 0 0 PF11817;PF12742; Q1RLY6 CHOYP_KMO.1.2 m.17496 sp KMO_DANRE 57.631 439 177 2 2 432 13 450 0 526 KMO_DANRE reviewed Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) kmo zgc:136684 Danio rerio (Zebrafish) (Brachydanio rerio) 474 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; kynurenine metabolic process [GO:0070189]; NAD metabolic process [GO:0019674]; quinolinate biosynthetic process [GO:0019805]; response to yeast [GO:0001878]; secondary metabolite biosynthetic process [GO:0044550]; tryptophan catabolic process [GO:0006569] GO:0001878; GO:0004502; GO:0005741; GO:0006569; GO:0016021; GO:0016174; GO:0019674; GO:0019805; GO:0034354; GO:0043420; GO:0044550; GO:0050660; GO:0070189; GO:0071949 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. {ECO:0000255|HAMAP-Rule:MF_03018}. 0 0 PF01494; Q1RMT1 CHOYP_ERCC3.1.1 m.34841 sp ERCC3_BOVIN 72.624 789 199 6 20 798 1 782 0 1191 ERCC3_BOVIN reviewed TFIIH basal transcription factor complex helicase XPB subunit (EC 3.6.4.12) (DNA excision repair protein ERCC-3) ERCC3 Bos taurus (Bovine) 782 "apoptotic process [GO:0006915]; DNA repair [GO:0006281]; DNA topological change [GO:0006265]; hair cell differentiation [GO:0035315]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; nucleotide-excision repair, DNA incision [GO:0033683]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization [GO:0008104]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; UV protection [GO:0009650]" GO:0000717; GO:0003677; GO:0004003; GO:0005524; GO:0005675; GO:0006265; GO:0006281; GO:0006283; GO:0006289; GO:0006366; GO:0006367; GO:0006915; GO:0006979; GO:0008022; GO:0008104; GO:0008353; GO:0009411; GO:0009650; GO:0016887; GO:0033683; GO:0035315; GO:0043065; GO:0043138; GO:0045944; GO:0047485; GO:1901990 0 0 0 PF16203;PF13625;PF04851; Q23551 CHOYP_PEVK.1.3 m.16129 sp UNC22_CAEEL 30.561 2994 1832 78 13 2904 3948 6796 0 1149 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_PEVK.2.3 m.21200 sp UNC22_CAEEL 29.355 3754 2330 97 2 3635 3245 6796 0 1316 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_PEVK.3.3 m.47806 sp UNC22_CAEEL 29.943 4238 2624 115 15 4119 2771 6796 0 1558 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_PHUM_PHUM226120.2.7 m.2274 sp UNC22_CAEEL 42.892 3243 1784 35 1448 4665 3842 7041 0 2608 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_PHUM_PHUM226120.3.7 m.20773 sp UNC22_CAEEL 42.315 3344 1857 37 1423 4739 3842 7140 0 2630 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_PHUM_PHUM226120.5.7 m.43551 sp UNC22_CAEEL 30.124 4611 2808 129 11759 16210 2441 6796 0 1655 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_PHUM_PHUM226120.7.7 m.54053 sp UNC22_CAEEL 42.404 3344 1854 37 1383 4699 3842 7140 0 2639 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_TITIN.19.19 m.66288 sp UNC22_CAEEL 29.941 4609 2819 124 7607 12058 2441 6796 0 1659 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q23551 CHOYP_UNC22.2.2 m.50516 sp UNC22_CAEEL 30.049 3055 1855 82 88 3023 3905 6796 0 1146 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q24270 CHOYP_CAC1D.1.1 m.35380 sp CAC1D_DROME 65.052 1631 475 15 77 1681 582 2143 0 2095 CAC1D_DROME reviewed Voltage-dependent calcium channel type D subunit alpha-1 (DmCa1D) Ca-alpha1D DroCa1 l(2)35Fa CG4894 Drosophila melanogaster (Fruit fly) 2516 calcium ion transport [GO:0006816]; epithelial fluid transport [GO:0042045]; membrane depolarization during action potential [GO:0086010]; muscle contraction [GO:0006936] GO:0005245; GO:0005891; GO:0006816; GO:0006936; GO:0008331; GO:0016323; GO:0016324; GO:0042045; GO:0046872; GO:0086010 0 0 0 PF08763;PF16885;PF16905;PF00520; Q24292 CHOYP_DS.1.1 m.62106 sp DS_DROME 35.757 3521 1878 83 36 3261 43 3474 0 1805 DS_DROME reviewed Protein dachsous (Adherin) ds CG17941 Drosophila melanogaster (Fruit fly) 3503 "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell morphogenesis involved in differentiation [GO:0000904]; cell proliferation [GO:0008283]; equator specification [GO:0045317]; establishment of cell polarity [GO:0030010]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; eye morphogenesis [GO:0048592]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing morphogenesis [GO:0007476]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; ommatidial rotation [GO:0016318]; peptide cross-linking [GO:0018149]; regulation of establishment of planar polarity [GO:0090175]; regulation of tube length, open tracheal system [GO:0035159]; single organismal cell-cell adhesion [GO:0016337]; wing disc pattern formation [GO:0035222]" GO:0000904; GO:0001736; GO:0001737; GO:0004871; GO:0004872; GO:0005509; GO:0005887; GO:0007156; GO:0007157; GO:0007164; GO:0007476; GO:0007480; GO:0008283; GO:0016021; GO:0016318; GO:0016337; GO:0016339; GO:0018149; GO:0030010; GO:0035159; GO:0035222; GO:0042067; GO:0044331; GO:0045198; GO:0045296; GO:0045317; GO:0048592; GO:0050839; GO:0090175; GO:0090176 0 0 0 PF00028; Q24498 CHOYP_LOC100643070.1.1 m.40176 sp RYR_DROME 50.103 3866 1613 64 1475 5173 1403 5119 0 3622 RYR_DROME reviewed Ryanodine receptor (Ryanodine receptor 44F) RyR dry Rya-r44F CG10844 Drosophila melanogaster (Fruit fly) 5127 calcium ion transport [GO:0006816]; heart contraction [GO:0060047]; multicellular organism development [GO:0007275]; muscle contraction [GO:0006936]; regulation of hemocyte proliferation [GO:0035206]; response to anesthetic [GO:0072347] GO:0005219; GO:0005875; GO:0006816; GO:0006936; GO:0007275; GO:0016021; GO:0033017; GO:0035206; GO:0060047; GO:0072347 0 0 0 PF08709;PF00520;PF02815;PF08454;PF06459;PF01365;PF02026;PF00622; Q24498 CHOYP_RY44.1.1 m.1016 sp RYR_DROME 50.321 4670 2026 75 8 4570 6 4488 0 4518 RYR_DROME reviewed Ryanodine receptor (Ryanodine receptor 44F) RyR dry Rya-r44F CG10844 Drosophila melanogaster (Fruit fly) 5127 calcium ion transport [GO:0006816]; heart contraction [GO:0060047]; multicellular organism development [GO:0007275]; muscle contraction [GO:0006936]; regulation of hemocyte proliferation [GO:0035206]; response to anesthetic [GO:0072347] GO:0005219; GO:0005875; GO:0006816; GO:0006936; GO:0007275; GO:0016021; GO:0033017; GO:0035206; GO:0060047; GO:0072347 0 0 0 PF08709;PF00520;PF02815;PF08454;PF06459;PF01365;PF02026;PF00622; Q24562 CHOYP_U2AF2.1.1 m.30416 sp U2AF2_DROME 75.457 383 81 4 97 469 37 416 0 610 U2AF2_DROME reviewed Splicing factor U2AF 50 kDa subunit (U2 auxiliary factor 50 kDa subunit) (U2 snRNP auxiliary factor large subunit) U2af50 CG9998 Drosophila melanogaster (Fruit fly) 416 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]; neurogenesis [GO:0022008]; nuclear export [GO:0051168]; positive regulation of RNA export from nucleus [GO:0046833]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" GO:0000166; GO:0000243; GO:0000381; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005681; GO:0007052; GO:0008187; GO:0008380; GO:0016607; GO:0022008; GO:0030628; GO:0046833; GO:0051168; GO:0071004; GO:0071011; GO:0089701 0 0 0 PF00076; Q25011 CHOYP_FANA.1.1 m.1274 sp FANA_HELAS 49.562 571 257 12 32 583 13 571 0 562 FANA_HELAS reviewed FMRFamide-activated amiloride-sensitive sodium channel (FANACH) 0 Helix aspersa (Brown garden snail) (Cornu aspersum) 625 0 GO:0005272; GO:0016021 0 0 0 PF00858; Q25117 CHOYP_ATPB.1.1 m.21960 sp ATPB_HEMPU 81.466 491 87 3 5 494 6 493 0 791 ATPB_HEMPU reviewed "ATP synthase subunit beta, mitochondrial (EC 3.6.3.14)" 0 Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus) 523 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0005524; GO:0005743; GO:0015986; GO:0015991; GO:0045261; GO:0046933 0 0 0 PF00006;PF02874; Q25189 CHOYP_GBLP.4.7 m.22254 sp GBLP_HYDVU 86.667 315 41 1 1 315 1 314 0 570 GBLP_HYDVU reviewed Guanine nucleotide-binding protein subunit beta-like protein (Receptor of activated protein kinase C) (RACK) RACK1 Hydra vulgaris (Hydra) (Hydra attenuata) 317 0 0 0 0 0 PF00400; Q25410 CHOYP_MIPR.1.2 m.43671 sp MIPR_LYMST 43.901 1369 631 31 42 1385 64 1320 0 1043 MIPR_LYMST reviewed Putative molluscan insulin-related peptide(s) receptor (EC 2.7.10.1) [Cleaved into: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 1607 transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0016021; GO:0046872 0 0 0 PF00041;PF00757;PF07714;PF01030; Q25410 CHOYP_MIPR.2.2 m.55505 sp MIPR_LYMST 44.189 1351 633 30 42 1365 64 1320 0 1048 MIPR_LYMST reviewed Putative molluscan insulin-related peptide(s) receptor (EC 2.7.10.1) [Cleaved into: Putative molluscan insulin-related peptide(s) receptor alpha chain; Putative molluscan insulin-related peptide(s) receptor beta chain] 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 1607 transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0016021; GO:0046872 0 0 0 PF00041;PF00757;PF07714;PF01030; Q26065 CHOYP_ACT.1.27 m.417 sp ACT_PLAMG 98.519 270 4 0 48 317 60 329 0 553 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q26065 CHOYP_ACT.10.27 m.28876 sp ACT_PLAMG 97.721 351 8 0 1 351 1 351 0 713 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q26065 CHOYP_ACT.17.27 m.45021 sp ACT_PLAMG 99.644 281 1 0 1 281 96 376 0 581 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q26065 CHOYP_ACT.3.27 m.10025 sp ACT_PLAMG 95.033 302 9 1 12 313 68 363 0 590 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q26065 CHOYP_ACT.5.27 m.15585 sp ACT_PLAMG 99.6 250 1 0 111 360 116 365 0 516 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q26626 CHOYP_LOC100371756.1.1 m.24048 sp KIFA3_STRPU 67.108 830 257 9 3 822 1 824 0 1077 KIFA3_STRPU reviewed Kinesin-associated protein 3 (SpKAP115) KAP115 Strongylocentrotus purpuratus (Purple sea urchin) 828 microtubule-based process [GO:0007017] GO:0007017; GO:0016939 0 0 0 0 Q27128 CHOYP_PAPSS.1.1 m.53055 sp PAPSS_URECA 76.421 598 141 0 12 609 8 605 0 987 PAPSS_URECA reviewed Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase (PAPS synthase) (PAPSS) (Sulfurylase kinase) (SK) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)] 0 Urechis caupo (Innkeeper worm) (Spoonworm) 610 sulfate assimilation [GO:0000103] GO:0000103; GO:0004020; GO:0004781; GO:0005524; GO:0016779 PATHWAY: Sulfur metabolism; sulfate assimilation. 0 cd02027;cd00517; PF01747;PF14306; Q27802 CHOYP_DYHC2.2.2 m.31941 sp DYHC2_TRIGR 67.369 4082 1298 18 1 4062 250 4317 0 5742 DYHC2_TRIGR reviewed Cytoplasmic dynein 2 heavy chain 1 (Dynein heavy chain isotype 1B) DYH1B Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) 4318 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018]; multicellular organism development [GO:0007275] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005886; GO:0005929; GO:0007018; GO:0007275; GO:0016887; GO:0030030; GO:0030286 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q27802 CHOYP_NEMVEDRAFT_V1G244113.1.1 m.22167 sp DYHC2_TRIGR 58.182 990 402 4 1 982 1 986 0 1224 DYHC2_TRIGR reviewed Cytoplasmic dynein 2 heavy chain 1 (Dynein heavy chain isotype 1B) DYH1B Tripneustes gratilla (Hawaian sea urchin) (Echinus gratilla) 4318 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018]; multicellular organism development [GO:0007275] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005886; GO:0005929; GO:0007018; GO:0007275; GO:0016887; GO:0030030; GO:0030286 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q27954 CHOYP_COPA.1.1 m.31888 sp COPA_BOVIN 80.91 1231 226 5 23 1251 1 1224 0 2126 COPA_BOVIN reviewed Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] COPA Bos taurus (Bovine) 1224 "ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005198; GO:0005576; GO:0006886; GO:0006888; GO:0006890; GO:0006891; GO:0030126 0 0 0 PF12894;PF04053;PF06957;PF00400; Q27955 CHOYP_BRAFLDRAFT_67317.1.2 m.56035 sp KCAB2_BOVIN 73.353 334 89 0 9 342 31 364 0 537 KCAB2_BOVIN reviewed Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) KCNAB2 KVB2 Bos taurus (Bovine) 367 hematopoietic progenitor cell differentiation [GO:0002244]; NADPH oxidation [GO:0070995]; neuromuscular process [GO:0050905]; oxidation-reduction process [GO:0055114]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008] GO:0002244; GO:0004033; GO:0005249; GO:0005829; GO:0005856; GO:0008076; GO:0014069; GO:0015459; GO:0016020; GO:0030054; GO:0030424; GO:0031234; GO:0034705; GO:0043005; GO:0043679; GO:0044224; GO:0050905; GO:0055114; GO:0070995; GO:1901379; GO:1990031; GO:2000008 0 0 cd06660; PF00248; Q27955 CHOYP_BRAFLDRAFT_67317.2.2 m.61758 sp KCAB2_BOVIN 68.732 355 90 1 28 382 31 364 0 522 KCAB2_BOVIN reviewed Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) KCNAB2 KVB2 Bos taurus (Bovine) 367 hematopoietic progenitor cell differentiation [GO:0002244]; NADPH oxidation [GO:0070995]; neuromuscular process [GO:0050905]; oxidation-reduction process [GO:0055114]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008] GO:0002244; GO:0004033; GO:0005249; GO:0005829; GO:0005856; GO:0008076; GO:0014069; GO:0015459; GO:0016020; GO:0030054; GO:0030424; GO:0031234; GO:0034705; GO:0043005; GO:0043679; GO:0044224; GO:0050905; GO:0055114; GO:0070995; GO:1901379; GO:1990031; GO:2000008 0 0 cd06660; PF00248; Q27968 CHOYP_DNJC3.1.1 m.52309 sp DNJC3_BOVIN 55.4 500 210 6 50 536 5 504 0 526 DNJC3_BOVIN reviewed "DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)" DNAJC3 P58IPK Bos taurus (Bovine) 504 cellular response to cold [GO:0070417]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of translation initiation in response to endoplasmic reticulum stress [GO:0036494]; response to unfolded protein [GO:0006986] GO:0004860; GO:0005783; GO:0005829; GO:0006469; GO:0006986; GO:0019901; GO:0036494; GO:0070417; GO:1903912 0 0 cd06257; PF00226;PF09976;PF13181; Q28021 CHOYP_ROCK2.1.1 m.26830 sp ROCK2_BOVIN 50.394 1395 635 24 11 1380 26 1388 0 1260 ROCK2_BOVIN reviewed "Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)" ROCK2 Bos taurus (Bovine) 1388 actin cytoskeleton organization [GO:0030036]; positive regulation of centrosome duplication [GO:0010825]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of circadian rhythm [GO:0042752]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005815; GO:0005829; GO:0005886; GO:0006939; GO:0007266; GO:0010825; GO:0030036; GO:0032956; GO:0042752; GO:0046872; GO:0048511 0 0 0 PF00069;PF08912; Q28811 CHOYP_PHR.1.1 m.7664 sp PHR_POTTR 64.244 509 180 1 71 577 19 527 0 698 PHR_POTTR reviewed Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (DNA photolyase) (Photoreactivating enzyme) PHR Potorous tridactylus (Potoroo) 532 DNA repair [GO:0006281]; protein-chromophore linkage [GO:0018298] GO:0003677; GO:0003904; GO:0006281; GO:0018298 0 0 0 PF00875; Q28824 CHOYP_MYLK.3.4 m.31133 sp MYLK_BOVIN 37.791 860 452 14 630 1461 355 1159 0 574 MYLK_BOVIN reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK Bos taurus (Bovine) 1176 positive regulation of cell migration [GO:0030335]; smooth muscle contraction [GO:0006939] GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0006939; GO:0030027; GO:0030335; GO:0032154; GO:0046872 0 0 0 PF00041;PF07679;PF00069; Q28BK1 CHOYP_HACE1.1.2 m.24806 sp HACE1_XENTR 59.956 919 352 8 1 914 5 912 0 1121 HACE1_XENTR reviewed E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) hace1 TEgg040h18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 912 cell cycle [GO:0007049]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cell migration [GO:0030334] GO:0000139; GO:0004842; GO:0005634; GO:0005737; GO:0005783; GO:0007030; GO:0007049; GO:0016567; GO:0016874; GO:0017137; GO:0030334; GO:0032580; GO:0042787; GO:0061025; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF00632; Q28BL6 CHOYP_AACS.1.1 m.66267 sp AACS_XENTR 62.727 660 238 5 11 665 16 672 0 883 AACS_XENTR reviewed Acetoacetyl-CoA synthetase (EC 6.2.1.16) aacs TEgg036g05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 672 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005829; GO:0006631; GO:0030729 0 0 0 PF16177;PF00501; Q28BS0 CHOYP_MCM3.1.1 m.14853 sp MCM3Z_XENTR 68.281 826 233 12 6 829 11 809 0 1118 MCM3Z_XENTR reviewed Zygotic DNA replication licensing factor mcm3 (EC 3.6.4.12) (Zygotic minichromosome maintenance protein 3) (zMCM3) zmcm3 TNeu014d13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 809 cell cycle [GO:0007049]; DNA replication initiation [GO:0006270] GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0006270; GO:0007049; GO:0042555 0 0 0 PF00493;PF14551; Q28BX9 CHOYP_C2CD5.1.1 m.9675 sp C2CD5_XENTR 47.723 1054 448 21 1 1017 1 988 0 920 C2CD5_XENTR reviewed C2 domain-containing protein 5 (138 kDa C2 domain-containing phosphoprotein) c2cd5 TGas115n11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1014 cellular response to insulin stimulus [GO:0032869]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; intracellular protein transmembrane transport [GO:0065002]; positive regulation of glucose transport [GO:0010828]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340] GO:0005509; GO:0005544; GO:0005886; GO:0005938; GO:0010828; GO:0030659; GO:0031340; GO:0032587; GO:0032869; GO:0038028; GO:0065002; GO:0090314 0 0 0 PF00168; Q28C33 CHOYP_BRAFLDRAFT_70346.1.1 m.16384 sp TBC30_XENTR 50.164 610 276 9 20 606 80 684 0 577 TBC30_XENTR reviewed TBC1 domain family member 30 tbc1d30 TEgg107a03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 907 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of cilium assembly [GO:1902017]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0072372; GO:0090630; GO:1902017 0 0 0 PF15733;PF00566; Q28D01 CHOYP_WDR26.1.1 m.43030 sp WDR26_XENTR 63.077 585 184 4 40 592 18 602 0 776 WDR26_XENTR reviewed WD repeat-containing protein 26 wdr26 TGas059a07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 614 0 GO:0005737 0 0 0 PF00400; Q28D84 CHOYP_EZH2.1.1 m.47916 sp EZH2_XENTR 54.293 757 256 14 58 735 2 747 0 790 EZH2_XENTR reviewed Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (Enhancer of zeste homolog 2) ezh2 TGas092f05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 748 "negative regulation of gene expression, epigenetic [GO:0045814]; regulation of transcription, DNA-templated [GO:0006355]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0018024; GO:0035098; GO:0045814; GO:0048511; GO:1990841 0 0 0 PF11616;PF00856; Q28DB0 CHOYP_BRAFLDRAFT_205333.1.1 m.9826 sp TT39B_XENTR 50.175 572 275 6 22 586 11 579 0 579 TT39B_XENTR reviewed Tetratricopeptide repeat protein 39B (TPR repeat protein 39B) ttc39b TEgg088o02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 588 0 0 0 0 0 PF10300;PF13181; Q28DH9 CHOYP_CEP76.1.1 m.6264 sp CEP76_XENTR 60.15 665 255 2 1 659 1 661 0 889 CEP76_XENTR reviewed Centrosomal protein of 76 kDa (Cep76) cep76 TEgg032c01.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 661 regulation of centriole replication [GO:0046599] GO:0005814; GO:0046599 0 0 0 PF15627; Q28DV3 CHOYP_LOC100368863.2.2 m.48484 sp HDAC3_XENTR 73.302 427 113 1 12 438 3 428 0 684 HDAC3_XENTR reviewed Histone deacetylase 3 (HD3) (EC 3.5.1.98) hdac3 TEgg067n06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 428 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003682; GO:0003714; GO:0005634; GO:0005737; GO:0006351; GO:0017053; GO:0032041 0 0 0 PF00850; Q28F07 CHOYP_ISCW_ISCW023973.1.2 m.6506 sp ANM1_XENTR 70.36 361 97 3 25 385 1 351 0 531 ANM1_XENTR reviewed Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 2) (Histone-arginine N-methyltransferase PRMT1) prmt1 hrmt1l2 TGas059i20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 351 "histone H4-R3 methylation [GO:0043985]; histone methylation [GO:0016571]; metamorphosis [GO:0007552]; negative regulation of megakaryocyte differentiation [GO:0045653]; neurogenesis [GO:0022008]; peptidyl-arginine methylation [GO:0018216]; positive regulation of transcription, DNA-templated [GO:0045893]; protein methylation [GO:0006479]; regulation of histone modification [GO:0031056]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0006479; GO:0007552; GO:0008170; GO:0008469; GO:0016274; GO:0016571; GO:0018216; GO:0022008; GO:0031056; GO:0035242; GO:0042054; GO:0043985; GO:0044020; GO:0045653; GO:0045893 0 0 0 0 Q28F07 CHOYP_ISCW_ISCW023973.2.2 m.59853 sp ANM1_XENTR 71.714 350 96 2 8 357 5 351 0 529 ANM1_XENTR reviewed Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 2) (Histone-arginine N-methyltransferase PRMT1) prmt1 hrmt1l2 TGas059i20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 351 "histone H4-R3 methylation [GO:0043985]; histone methylation [GO:0016571]; metamorphosis [GO:0007552]; negative regulation of megakaryocyte differentiation [GO:0045653]; neurogenesis [GO:0022008]; peptidyl-arginine methylation [GO:0018216]; positive regulation of transcription, DNA-templated [GO:0045893]; protein methylation [GO:0006479]; regulation of histone modification [GO:0031056]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0006479; GO:0007552; GO:0008170; GO:0008469; GO:0016274; GO:0016571; GO:0018216; GO:0022008; GO:0031056; GO:0035242; GO:0042054; GO:0043985; GO:0044020; GO:0045653; GO:0045893 0 0 0 0 Q28F67 CHOYP_AATM.1.1 m.32176 sp AATM_XENTR 68.25 400 127 0 33 432 28 427 0 600 AATM_XENTR reviewed "Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Transaminase A)" got2 TGas123d19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 427 2-oxoglutarate metabolic process [GO:0006103]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536] GO:0004069; GO:0005739; GO:0005759; GO:0005886; GO:0006103; GO:0006531; GO:0006533; GO:0006536; GO:0009058; GO:0016212; GO:0030170; GO:0042802; GO:0080130 0 0 0 PF00155; Q28GH3 CHOYP_SAE2.1.1 m.59765 sp SAE2_XENTR 59.219 640 233 7 3 615 2 640 0 762 SAE2_XENTR reviewed SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) uba2 sae2 uble1b TEgg032e11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 641 protein sumoylation [GO:0016925] GO:0005524; GO:0005829; GO:0016925; GO:0019948; GO:0031510; GO:0046872 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00899;PF14732;PF16195; Q28I85 CHOYP_LOC100378584.2.3 m.45658 sp POC1A_XENTR 66.284 436 127 5 1 426 1 426 0 590 POC1A_XENTR reviewed POC1 centriolar protein homolog A (Pat-interacting protein 2) (Pix2) (xPix2) (WD repeat-containing protein 51A) poc1a wdr51a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 441 0 GO:0005737; GO:0005856 0 0 0 PF00400; Q28I85 CHOYP_LOC100378584.3.3 m.63219 sp POC1A_XENTR 62.741 467 121 7 1 455 1 426 0 583 POC1A_XENTR reviewed POC1 centriolar protein homolog A (Pat-interacting protein 2) (Pix2) (xPix2) (WD repeat-containing protein 51A) poc1a wdr51a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 441 0 GO:0005737; GO:0005856 0 0 0 PF00400; Q29451 CHOYP_MAN2B1.1.1 m.38450 sp MA2B1_BOVIN 49.652 1007 448 14 26 1021 35 993 0 947 MA2B1_BOVIN reviewed Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] MAN2B1 MANB Bos taurus (Bovine) 999 learning or memory [GO:0007611]; mannose metabolic process [GO:0006013]; protein deglycosylation [GO:0006517] GO:0004559; GO:0005764; GO:0006013; GO:0006517; GO:0007611; GO:0008270; GO:0030246 0 0 0 PF09261;PF01074;PF07748; Q29IL2 CHOYP_LOC662234.1.1 m.56676 sp POMT2_DROPS 49.401 751 320 5 24 738 10 736 0 749 POMT2_DROPS reviewed Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) (Protein twisted) tw GA11548 Drosophila pseudoobscura pseudoobscura (Fruit fly) 749 lipid glycosylation [GO:0030259]; muscle organ development [GO:0007517] GO:0004169; GO:0005783; GO:0005789; GO:0007517; GO:0016021; GO:0030259 PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}. 0 0 PF02815;PF02366;PF16192; Q29P71 CHOYP_MYO7A.3.3 m.66876 sp MYO7A_DROPS 35.236 1209 690 17 154 1309 995 2163 0 762 MYO7A_DROPS reviewed Myosin-VIIa (Protein crinkled) ck GA20466 Drosophila pseudoobscura pseudoobscura (Fruit fly) 2168 actin filament-based movement [GO:0030048]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; imaginal disc-derived wing hair organization [GO:0035317]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0008407; GO:0016459; GO:0030048; GO:0030898; GO:0032027; GO:0035317; GO:0048800 0 0 0 PF00373;PF00612;PF00063;PF00784; Q29RK2 CHOYP_LOC100367726.2.2 m.57476 sp PYC_BOVIN 68.412 1165 345 2 54 1218 37 1178 0 1669 PYC_BOVIN reviewed "Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)" PC Bos taurus (Bovine) 1178 gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral release from host cell [GO:0044791]; pyruvate metabolic process [GO:0006090]; viral RNA genome packaging [GO:0019074] GO:0003677; GO:0004075; GO:0004736; GO:0005524; GO:0005739; GO:0005743; GO:0005759; GO:0006090; GO:0006094; GO:0006629; GO:0009374; GO:0010629; GO:0019074; GO:0044791; GO:0046872 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. 0 0 PF02785;PF00289;PF00364;PF02786;PF00682;PF02436; Q29RQ5 CHOYP_PHUM_PHUM349810.1.2 m.7706 sp TRIM9_BOVIN 46.841 728 337 13 1 709 4 700 0 679 TRIM9_BOVIN reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) TRIM9 Bos taurus (Bovine) 710 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016874; GO:0030054; GO:0030425; GO:0043161 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643;PF13445; Q29RQ5 CHOYP_PHUM_PHUM349810.2.2 m.53532 sp TRIM9_BOVIN 48.164 708 333 13 21 705 4 700 0 684 TRIM9_BOVIN reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) TRIM9 Bos taurus (Bovine) 710 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016874; GO:0030054; GO:0030425; GO:0043161 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643;PF13445; Q29RZ2 CHOYP_PPWD1.1.1 m.48713 sp PPWD1_BOVIN 68.677 597 186 1 19 615 49 644 0 900 PPWD1_BOVIN reviewed Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) PPWD1 Bos taurus (Bovine) 644 mRNA processing [GO:0006397]; protein folding [GO:0006457]; RNA splicing [GO:0008380] GO:0003755; GO:0006397; GO:0006457; GO:0008380; GO:0071013 0 0 0 PF00160;PF00400; Q29RZ9 CHOYP_WDR92.1.1 m.12560 sp WDR92_BOVIN 78.31 355 76 1 1 355 4 357 0 576 WDR92_BOVIN reviewed WD repeat-containing protein 92 WDR92 Bos taurus (Bovine) 357 apoptotic process [GO:0006915] GO:0006915; GO:0043130 0 0 0 PF00400; Q2A865 CHOYP_DANA_GF21785.1.1 m.66202 sp S6A19_RAT 45.134 596 278 6 141 695 17 604 0 539 S6A19_RAT reviewed Sodium-dependent neutral amino acid transporter B(0)AT1 (Solute carrier family 6 member 19) (System B(0) neutral amino acid transporter AT1) Slc6a19 B0at1 Rattus norvegicus (Rat) 634 response to nutrient [GO:0007584] GO:0005328; GO:0005887; GO:0007584; GO:0015175; GO:0031526; GO:0070062 0 0 0 PF00209; Q2HJG5 CHOYP_VPS35.1.1 m.55447 sp VPS35_BOVIN 74.969 803 193 4 1 802 1 796 0 1235 VPS35_BOVIN reviewed Vacuolar protein sorting-associated protein 35 (Vesicle protein sorting 35) VPS35 Bos taurus (Bovine) 796 "intracellular protein transport [GO:0006886]; negative regulation of late endosome to lysosome transport [GO:1902823]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt protein secretion [GO:0061357]; regulation of protein stability [GO:0031647]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde transport, endosome to plasma membrane [GO:1990126]; transcytosis [GO:0045056]" GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005829; GO:0006886; GO:0008565; GO:0030904; GO:0031647; GO:0042147; GO:0045056; GO:0061357; GO:0070062; GO:0090263; GO:0097422; GO:1902823; GO:1990126 0 0 0 PF03635; Q2HJH1 CHOYP_BRAFLDRAFT_69005.1.1 m.26462 sp DNPEP_BOVIN 58.761 468 183 4 22 485 7 468 0 582 DNPEP_BOVIN reviewed Aspartyl aminopeptidase (EC 3.4.11.21) DNPEP Bos taurus (Bovine) 471 peptide metabolic process [GO:0006518] GO:0005576; GO:0005654; GO:0005737; GO:0006518; GO:0008270; GO:0070006; GO:0072562 0 0 0 PF02127; Q2KHT3 CHOYP_LOC410511.1.2 m.10509 sp CL16A_HUMAN 57.728 854 309 9 33 858 1 830 0 971 CL16A_HUMAN reviewed Protein CLEC16A (C-type lectin domain family 16 member A) CLEC16A KIAA0350 Homo sapiens (Human) 1053 autophagy [GO:0006914] GO:0005765; GO:0006914; GO:0010008 0 0 0 PF09758; Q2KJC6 CHOYP_LOC100652183.1.1 m.18254 sp METK1_BOVIN 66.591 440 100 3 10 449 4 396 0 601 METK1_BOVIN reviewed S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) MAT1A Bos taurus (Bovine) 396 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0005829; GO:0006556; GO:0006730; GO:0046872 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q2KJC6 CHOYP_METK.1.2 m.3732 sp METK1_BOVIN 73.537 393 98 1 19 411 10 396 0 620 METK1_BOVIN reviewed S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) MAT1A Bos taurus (Bovine) 396 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0005829; GO:0006556; GO:0006730; GO:0046872 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q2KJC6 CHOYP_METK.2.2 m.25360 sp METK1_BOVIN 72.752 367 94 1 38 404 10 370 0 566 METK1_BOVIN reviewed S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) MAT1A Bos taurus (Bovine) 396 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0005829; GO:0006556; GO:0006730; GO:0046872 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q2KJC9 CHOYP_LOC100699093.1.1 m.20134 sp AL7A1_BOVIN 70.254 511 152 0 1 511 29 539 0 761 AL7A1_BOVIN reviewed Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) ALDH7A1 Bos taurus (Bovine) 539 glycine betaine biosynthetic process from choline [GO:0019285] GO:0004029; GO:0004043; GO:0005634; GO:0005739; GO:0005829; GO:0008802; GO:0019285 PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. 0 0 PF00171; Q2KJG3 CHOYP_ISCW_ISCW021591.1.1 m.13970 sp SYNC_BOVIN 72.613 555 152 0 4 558 5 559 0 872 SYNC_BOVIN reviewed "Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)" NARS Bos taurus (Bovine) 559 asparaginyl-tRNA aminoacylation [GO:0006421] GO:0003676; GO:0004816; GO:0005524; GO:0005737; GO:0006421 0 0 0 PF00152;PF01336; Q2KJI2 CHOYP_STT3A.1.1 m.40532 sp STT3A_BOVIN 83.595 701 114 1 13 713 6 705 0 1229 STT3A_BOVIN reviewed Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) STT3A Bos taurus (Bovine) 705 co-translational protein modification [GO:0043686]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279] GO:0004579; GO:0008250; GO:0016021; GO:0018279; GO:0043686; GO:0043687 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02516; Q2KJJ0 CHOYP_PRP6.2.2 m.34363 sp PRP6_BOVIN 73.792 538 122 4 13 532 1 537 0 780 PRP6_BOVIN reviewed Pre-mRNA-processing factor 6 (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) PRPF6 Bos taurus (Bovine) 941 positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; RNA localization [GO:0006403]; spliceosomal tri-snRNP complex assembly [GO:0000244] GO:0000244; GO:0003713; GO:0005682; GO:0006403; GO:0016020; GO:0016607; GO:0043021; GO:0044822; GO:0045944; GO:0046540; GO:0071013 0 0 0 PF06424; Q2M389 CHOYP_BRAFLDRAFT_221115.1.1 m.28512 sp WASH7_HUMAN 64.12 1165 407 4 12 1167 9 1171 0 1583 WASH7_HUMAN reviewed WASH complex subunit 7 (Strumpellin and WASH-interacting protein) (SWIP) KIAA1033 Homo sapiens (Human) 1173 endosomal transport [GO:0016197]; endosome organization [GO:0007032]; protein transport [GO:0015031] GO:0005654; GO:0005768; GO:0005769; GO:0007032; GO:0015031; GO:0016197; GO:0071203 0 0 0 PF14746;PF14744;PF14745; Q2M389 CHOYP_LOC100372619.2.2 m.63331 sp WASH7_HUMAN 69.565 552 165 1 1 549 620 1171 0 806 WASH7_HUMAN reviewed WASH complex subunit 7 (Strumpellin and WASH-interacting protein) (SWIP) KIAA1033 Homo sapiens (Human) 1173 endosomal transport [GO:0016197]; endosome organization [GO:0007032]; protein transport [GO:0015031] GO:0005654; GO:0005768; GO:0005769; GO:0007032; GO:0015031; GO:0016197; GO:0071203 0 0 0 PF14746;PF14744;PF14745; Q2NKQ1 CHOYP_SGSM1.1.2 m.636 sp SGSM1_HUMAN 51.05 1191 443 25 2 1097 3 1148 0 1103 SGSM1_HUMAN reviewed Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) SGSM1 KIAA1941 RUTBC2 Homo sapiens (Human) 1148 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0005737; GO:0005794; GO:0005829; GO:0006886; GO:0012505; GO:0017137; GO:0030659; GO:0031338; GO:0090630 0 0 0 PF00566;PF02759; Q2NL17 CHOYP_CLPT1.1.1 m.50172 sp CLPT1_BOVIN 58.039 622 245 4 12 618 27 647 0 760 CLPT1_BOVIN reviewed Cleft lip and palate transmembrane protein 1 homolog CLPTM1 Bos taurus (Bovine) 670 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0007275; GO:0016021; GO:0030154 0 0 0 PF05602; Q2PC93 CHOYP_LOC100497129.3.8 m.32060 sp SSPO_CHICK 32.81 1719 955 60 12 1666 7 1589 0 824 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q2PC93 CHOYP_LOC100497129.6.8 m.41866 sp SSPO_CHICK 35.609 1362 762 43 4 1322 300 1589 0 773 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q2PC93 CHOYP_LOC100497129.7.8 m.41875 sp SSPO_CHICK 32.81 1719 955 60 12 1666 7 1589 0 822 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q2PPJ7 CHOYP_LOC100880013.1.1 m.64151 sp RGPA2_HUMAN 39.295 1929 969 43 7 1799 1 1863 0 1260 RGPA2_HUMAN reviewed Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) RALGAPA2 C20orf74 KIAA1272 Homo sapiens (Human) 1873 activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0005615; GO:0005737; GO:0005886; GO:0046982; GO:0051056; GO:0090630 0 0 0 PF02145; Q2PPJ7 CHOYP_RGPA1.1.1 m.50924 sp RGPA2_HUMAN 38.931 1965 993 43 7 1866 1 1863 0 1277 RGPA2_HUMAN reviewed Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220) RALGAPA2 C20orf74 KIAA1272 Homo sapiens (Human) 1873 activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0005615; GO:0005737; GO:0005886; GO:0046982; GO:0051056; GO:0090630 0 0 0 PF02145; Q2PZI1 CHOYP_BRAFLDRAFT_269194.1.1 m.53515 sp D19L1_HUMAN 52.519 655 294 5 58 708 33 674 0 701 D19L1_HUMAN reviewed Probable C-mannosyltransferase DPY19L1 (EC 2.4.1.-) (Dpy-19-like protein 1) (Protein dpy-19 homolog 1) DPY19L1 GA0500 KIAA0877 Homo sapiens (Human) 675 protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan [GO:0018406] GO:0000030; GO:0005637; GO:0016020; GO:0016021; GO:0018406 0 0 0 PF10034; Q2PZL6 CHOYP_LOC100636493.1.1 m.65727 sp FAT4_MOUSE 26.2 3771 2452 142 661 4302 51 3619 0 681 FAT4_MOUSE reviewed Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0008543; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072006; GO:0072137; GO:0072307 0 0 0 PF00028;PF00008;PF07645;PF12661;PF02210; Q2PZL6 CHOYP_MBCDH18.1.1 m.34344 sp FAT4_MOUSE 27.011 3717 2418 143 796 4407 81 3607 0 733 FAT4_MOUSE reviewed Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0008543; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072006; GO:0072137; GO:0072307 0 0 0 PF00028;PF00008;PF07645;PF12661;PF02210; Q2T9K6 CHOYP_FEM1C.1.1 m.55969 sp FEM1C_XENLA 57.76 625 252 6 1 622 1 616 0 749 FEM1C_XENLA reviewed Protein fem-1 homolog C (FEM1c) (FEM1-gamma) fem1c Xenopus laevis (African clawed frog) 617 protein ubiquitination [GO:0016567] GO:0005737; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q2T9X2 CHOYP_TCPD.1.1 m.13556 sp TCPD_BOVIN 77.027 518 117 2 16 532 24 540 0 827 TCPD_BOVIN reviewed T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) CCT4 Bos taurus (Bovine) 542 protein folding [GO:0006457] GO:0005524; GO:0005815; GO:0005832; GO:0005929; GO:0006457; GO:0042470 0 0 cd03338; PF00118; Q2TA14 CHOYP_PCP.1.1 m.59309 sp PCP_BOVIN 54.67 439 198 1 61 498 50 488 0 521 PCP_BOVIN reviewed Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) PRCP Bos taurus (Bovine) 499 angiogenesis involved in wound healing [GO:0060055]; negative regulation of systemic arterial blood pressure [GO:0003085]; proteolysis [GO:0006508]; regulation of blood vessel endothelial cell migration [GO:0043535] GO:0003085; GO:0004185; GO:0005764; GO:0006508; GO:0008239; GO:0043535; GO:0060055 0 0 0 PF05577; Q2TBE0 CHOYP_LOC100366505.1.1 m.47365 sp C19L2_HUMAN 41.176 935 444 26 7 890 12 891 0 590 C19L2_HUMAN reviewed CWF19-like protein 2 CWF19L2 Homo sapiens (Human) 894 0 GO:0003824 0 0 0 PF04677;PF04676; Q2VJ60 CHOYP_MYS.2.7 m.2064 sp RN19A_PIG 63.34 521 151 13 104 610 131 625 0 652 RN19A_PIG reviewed E3 ubiquitin-protein ligase RNF19A (EC 6.3.2.-) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) RNF19A RNF19 Sus scrofa (Pig) 838 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005737; GO:0005813; GO:0008270; GO:0016021; GO:0016874; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; Q2VPA6 CHOYP_HELQ.1.1 m.15965 sp HELQ_MOUSE 47.184 1083 506 21 66 1110 2 1056 0 931 HELQ_MOUSE reviewed Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase) Helq Hel308 Mus musculus (Mouse) 1069 DNA metabolic process [GO:0006259]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0003676; GO:0005524; GO:0005654; GO:0005730; GO:0006259; GO:0017116; GO:0017117 0 0 0 PF00270;PF00271; Q32KH5 CHOYP_GALNS.1.1 m.66165 sp GALNS_CANLF 65.992 494 165 3 20 511 30 522 0 709 GALNS_CANLF reviewed N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) GALNS Canis lupus familiaris (Dog) (Canis familiaris) 522 metabolic process [GO:0008152] GO:0005764; GO:0008152; GO:0043890; GO:0046872 0 0 0 PF00884; Q32KN8 CHOYP_TBA1.3.9 m.12252 sp TBA3_BOVIN 90.796 402 32 1 1 397 1 402 0 749 TBA3_BOVIN reviewed Tubulin alpha-3 chain (Alpha-tubulin 3) [Cleaved into: Detyrosinated tubulin alpha-3 chain] TUBA3 Bos taurus (Bovine) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q32LP4 CHOYP_S4A10.2.4 m.24326 sp S4A10_BOVIN 50.436 1148 474 25 3 1122 17 1097 0 1054 S4A10_BOVIN reviewed Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) SLC4A10 Bos taurus (Bovine) 1117 anion transmembrane transport [GO:0098656]; bicarbonate transport [GO:0015701]; nervous system development [GO:0007399]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005452; GO:0005887; GO:0006814; GO:0007399; GO:0008509; GO:0015293; GO:0015297; GO:0015701; GO:0051453; GO:0098656 0 0 0 PF07565;PF00955; Q32LQ6 CHOYP_BRAFLDRAFT_277055.1.2 m.3095 sp MFSD1_DANRE 62.295 427 161 0 35 461 32 458 0 538 MFSD1_DANRE reviewed Major facilitator superfamily domain-containing protein 1 mfsd1 zgc:123187 Danio rerio (Zebrafish) (Brachydanio rerio) 461 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q32N90 CHOYP_SMBT.1.1 m.34995 sp MBTD1_XENLA 54.312 545 222 9 85 615 52 583 0 595 MBTD1_XENLA reviewed MBT domain-containing protein 1 mbtd1 Xenopus laevis (African clawed frog) 621 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016569 0 0 0 PF02820; Q32PH0 CHOYP_TRAPPC9.1.1 m.24975 sp TPPC9_BOVIN 36.097 989 554 21 240 1164 131 1105 0 630 TPPC9_BOVIN reviewed Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) TRAPPC9 NIBP Bos taurus (Bovine) 1138 cell differentiation [GO:0030154] GO:0005783; GO:0005802; GO:0030154 0 0 0 PF08626; Q32PJ3 CHOYP_LOC592407.1.1 m.16716 sp ORC3_BOVIN 41.528 720 390 10 22 721 4 712 0 571 ORC3_BOVIN reviewed Origin recognition complex subunit 3 ORC3 ORC3L Bos taurus (Bovine) 712 DNA replication initiation [GO:0006270]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267] GO:0000784; GO:0003688; GO:0005656; GO:0005664; GO:0006267; GO:0006270; GO:0031261 0 0 0 PF07034; Q32PW3 CHOYP_LOC100706922.1.1 m.39568 sp TAF2_DANRE 53.109 1158 490 11 2 1143 4 1124 0 1250 TAF2_DANRE reviewed Transcription initiation factor TFIID subunit 2 (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150) taf2 Danio rerio (Zebrafish) (Brachydanio rerio) 1191 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001129; GO:0003682; GO:0005669; GO:0008237; GO:0008270; GO:0043565; GO:0044212; GO:0045944 0 0 0 PF01433; Q32TF8 CHOYP_LOC100377378.1.1 m.64418 sp EFHC2_DANRE 57.315 745 311 6 1 741 1 742 0 893 EFHC2_DANRE reviewed EF-hand domain-containing family member C2 efhc2 zgc:152706 Danio rerio (Zebrafish) (Brachydanio rerio) 748 0 0 0 0 0 PF06565; Q38SD2 CHOYP_LOC100366408.1.1 m.37601 sp LRRK1_HUMAN 29.106 1711 1047 46 76 1757 86 1659 0 652 LRRK1_HUMAN reviewed Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) LRRK1 KIAA1790 Homo sapiens (Human) 2015 bone resorption [GO:0045453]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; osteoclast development [GO:0036035]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; small GTPase mediated signal transduction [GO:0007264] GO:0004674; GO:0005524; GO:0005525; GO:0005737; GO:0005739; GO:0007264; GO:0036035; GO:0042802; GO:0045453; GO:0046872; GO:0050731; GO:0050732; GO:0090263; GO:1902533 0 0 0 PF12796;PF16095;PF00069;PF08477; Q39575 CHOYP_LOC577805.1.4 m.9698 sp DYHG_CHLRE 28.651 1801 1041 31 708 2499 472 2037 0 786 DYHG_CHLRE reviewed "Dynein gamma chain, flagellar outer arm" ODA2 ODA-2 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4485 cilium movement involved in cell motility [GO:0060294]; outer dynein arm assembly [GO:0036158] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0016887; GO:0030286; GO:0031514; GO:0036158; GO:0060294 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q3B8Q1 CHOYP_LOC101075553.1.1 m.15258 sp DDX21_RAT 53.02 596 261 8 49 633 162 749 0 592 DDX21_RAT reviewed Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) Ddx21 Ddx21a Rattus norvegicus (Rat) 782 RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364]; transcription from RNA polymerase II promoter [GO:0006366] GO:0004004; GO:0005524; GO:0005654; GO:0005730; GO:0006364; GO:0006366; GO:0010501; GO:0019843; GO:0030515; GO:0097322 0 0 0 PF00270;PF08152;PF00271; Q3L1C9 CHOYP_LOC100533450.1.1 m.54334 sp STAUH_APLCA 52.416 683 278 15 63 709 261 932 0 583 STAUH_APLCA reviewed Double-stranded RNA-binding protein Staufen homolog 0 Aplysia californica (California sea hare) 950 regulation of protein localization [GO:0032880] GO:0003729; GO:0032880; GO:0043005; GO:0043025 0 0 0 PF00035;PF16482; Q3SYU1 CHOYP_LOC101076180.1.1 m.41749 sp NOC2L_BOVIN 48.897 544 269 7 205 743 134 673 0 552 NOC2L_BOVIN reviewed Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2-like protein) (Novel INHAT repressor) NOC2L NIR Bos taurus (Bovine) 746 "apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; chromatin assembly [GO:0031497]; negative regulation of B cell apoptotic process [GO:0002903]; negative regulation of histone acetylation [GO:0035067]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleolus to nucleoplasm transport [GO:0032066]; ribosomal large subunit biogenesis [GO:0042273]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002903; GO:0003682; GO:0003714; GO:0005654; GO:0005730; GO:0005737; GO:0006351; GO:0006915; GO:0030690; GO:0030691; GO:0031497; GO:0032066; GO:0034644; GO:0035067; GO:0042273; GO:0042393; GO:0044822; GO:0070491; GO:2001243 0 0 0 PF03715; Q3SYZ4 CHOYP_LOC100186203.1.1 m.7876 sp SYDC_BOVIN 72.141 481 131 1 52 529 21 501 0 749 SYDC_BOVIN reviewed "Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS)" DARS Bos taurus (Bovine) 501 aspartyl-tRNA aminoacylation [GO:0006422] GO:0003676; GO:0004815; GO:0005524; GO:0005737; GO:0006422 0 0 0 PF00152;PF01336; Q3SZH7 CHOYP_BRAFLDRAFT_215361.1.1 m.55455 sp LKHA4_BOVIN 54.844 609 269 4 8 613 6 611 0 722 LKHA4_BOVIN reviewed Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H Bos taurus (Bovine) 611 leukotriene biosynthetic process [GO:0019370]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004177; GO:0004301; GO:0004463; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0019370; GO:0042277; GO:0043171; GO:0044822; GO:0070006; GO:0070062 PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. 0 0 PF09127;PF01433; Q3T0K2 CHOYP_LOC100372926.2.3 m.61794 sp TCPG_BOVIN 72.089 541 150 1 167 707 3 542 0 838 TCPG_BOVIN reviewed T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) CCT3 Bos taurus (Bovine) 545 binding of sperm to zona pellucida [GO:0007339]; pore complex assembly [GO:0046931]; protein folding [GO:0006457]; toxin transport [GO:1901998] GO:0002199; GO:0005524; GO:0005832; GO:0005874; GO:0005886; GO:0006457; GO:0007339; GO:0043209; GO:0044297; GO:0044822; GO:0046931; GO:0070062; GO:1901998 0 0 cd03337; PF00118; Q3T0K2 CHOYP_LOC100372926.3.3 m.66074 sp TCPG_BOVIN 72.274 541 149 1 4 544 3 542 0 838 TCPG_BOVIN reviewed T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) CCT3 Bos taurus (Bovine) 545 binding of sperm to zona pellucida [GO:0007339]; pore complex assembly [GO:0046931]; protein folding [GO:0006457]; toxin transport [GO:1901998] GO:0002199; GO:0005524; GO:0005832; GO:0005874; GO:0005886; GO:0006457; GO:0007339; GO:0043209; GO:0044297; GO:0044822; GO:0046931; GO:0070062; GO:1901998 0 0 cd03337; PF00118; Q3T0P6 CHOYP_PGK1.1.1 m.27254 sp PGK1_BOVIN 75.669 411 99 1 4 413 5 415 0 624 PGK1_BOVIN reviewed Phosphoglycerate kinase 1 (EC 2.7.2.3) PGK1 Bos taurus (Bovine) 417 epithelial cell differentiation [GO:0030855]; glycolytic process [GO:0006096] GO:0004618; GO:0005524; GO:0005737; GO:0006096; GO:0030855; GO:0045121; GO:0070062 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. 0 cd00318; PF00162; Q3T0R7 CHOYP_ACAA2.1.1 m.30666 sp THIM_BOVIN 62.814 398 144 2 1 398 1 394 0 532 THIM_BOVIN reviewed "3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase)" ACAA2 Bos taurus (Bovine) 397 cellular response to hypoxia [GO:0071456]; fatty acid metabolic process [GO:0006631]; negative regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902109]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029] GO:0003988; GO:0005739; GO:0005743; GO:0006631; GO:0044822; GO:0070062; GO:0071456; GO:1901029; GO:1902109 PATHWAY: Lipid metabolism; fatty acid metabolism. 0 0 PF02803;PF00108; Q3T147 CHOYP_DX39B.1.3 m.16941 sp DX39B_BOVIN 69.591 342 104 0 1 342 83 424 0 518 DX39B_BOVIN reviewed Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) DDX39B BAT1 UAP56 Bos taurus (Bovine) 428 "cellular response to DNA damage stimulus [GO:0006974]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of gene expression [GO:0010468]; RNA secondary structure unwinding [GO:0010501]; spliceosomal complex assembly [GO:0000245]; viral mRNA export from host cell nucleus [GO:0046784]" GO:0000245; GO:0000346; GO:0000398; GO:0004004; GO:0005524; GO:0005681; GO:0005687; GO:0005688; GO:0005737; GO:0006406; GO:0006974; GO:0010468; GO:0010501; GO:0016607; GO:0017070; GO:0030621; GO:0032786; GO:0044822; GO:0046784; GO:2000002 0 0 0 PF00270;PF00271; Q3TDN0 CHOYP_DISP1.1.1 m.41242 sp DISP1_MOUSE 39.899 995 557 16 17 988 168 1144 0 754 DISP1_MOUSE reviewed Protein dispatched homolog 1 (Mdispa) Disp1 Disp Dispa Icb Icbins Mus musculus (Mouse) 1521 determination of left/right symmetry [GO:0007368]; diaphragm development [GO:0060539]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; patched ligand maturation [GO:0007225]; pattern specification process [GO:0007389]; peptide transport [GO:0015833]; smoothened signaling pathway [GO:0007224] GO:0007224; GO:0007225; GO:0007368; GO:0007389; GO:0009880; GO:0009953; GO:0015197; GO:0015833; GO:0016021; GO:0060539 0 0 0 PF02460; Q3TIX9 CHOYP_SNUT2.1.1 m.19264 sp SNUT2_MOUSE 65.234 535 161 6 80 591 22 554 0 691 SNUT2_MOUSE reviewed U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39) Usp39 Mus musculus (Mouse) 564 cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA processing [GO:0006397]; protein deubiquitination [GO:0016579]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0007049; GO:0008270; GO:0008380; GO:0016579; GO:0036459; GO:0051301 0 0 0 PF00443;PF02148; Q3TLI0 CHOYP_TPC10.1.1 m.38374 sp TPC10_MOUSE 36.941 1007 550 19 1 931 15 1012 0 631 TPC10_MOUSE reviewed Trafficking protein particle complex subunit 10 (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) Trappc10 Tmem1 Mus musculus (Mouse) 1259 early endosome to Golgi transport [GO:0034498]; intra-Golgi vesicle-mediated transport [GO:0006891] GO:0005829; GO:0006891; GO:0034498; GO:1990071 0 0 0 PF12584; Q3TNA1 CHOYP_BRAFLDRAFT_124284.1.1 m.33673 sp XYLB_MOUSE 56.647 519 222 1 6 521 22 540 0 617 XYLB_MOUSE reviewed Xylulose kinase (Xylulokinase) (EC 2.7.1.17) Xylb Mus musculus (Mouse) 551 D-xylose metabolic process [GO:0042732]; xylulose metabolic process [GO:0005997] GO:0004856; GO:0005524; GO:0005737; GO:0005997; GO:0042732; GO:0070062 0 0 0 PF02782;PF00370; Q3TX08 CHOYP_TRMT1.1.1 m.48190 sp TRM1_MOUSE 50.093 537 254 5 33 557 58 592 0 546 TRM1_MOUSE reviewed "tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)" Trmt1 D8Ertd812e Mus musculus (Mouse) 663 tRNA N2-guanine methylation [GO:0002940] GO:0000049; GO:0002940; GO:0004809; GO:0005634; GO:0005739; GO:0044822; GO:0046872 0 0 0 PF02005;PF00642; Q3TZZ7 CHOYP_AAEL_AAEL009169.1.1 m.24699 sp ESYT2_MOUSE 37.931 812 444 14 36 807 50 841 0 552 ESYT2_MOUSE reviewed Extended synaptotagmin-2 (E-Syt2) Esyt2 D12Ertd551e Fam62b Mus musculus (Mouse) 845 endocytosis [GO:0006897]; lipid transport [GO:0006869] GO:0005509; GO:0005544; GO:0005887; GO:0006869; GO:0006897; GO:0008429; GO:0016020; GO:0031210; GO:0031227; GO:0031234; GO:0035091; GO:0042802; GO:0044232 0 0 0 PF00168;PF17047; Q3U1V8 CHOYP_LOC100366440.1.1 m.12198 sp M3K9_MOUSE 57.458 590 198 7 29 574 49 629 0 669 M3K9_MOUSE reviewed Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) Map3k9 Mus musculus (Mouse) 1077 "apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0004674; GO:0004709; GO:0005524; GO:0005622; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0043065; GO:0046777 0 0 0 PF00069;PF14604; Q3U3R4 CHOYP_BRAFLDRAFT_200916.1.1 m.17359 sp LMF1_MOUSE 57.923 568 228 6 5 565 8 571 0 663 LMF1_MOUSE reviewed Lipase maturation factor 1 (Transmembrane protein 112) Lmf1 Tmem112 Mus musculus (Mouse) 574 chylomicron remnant clearance [GO:0034382]; ER to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of lipoprotein lipase activity [GO:0051006]; protein glycosylation in Golgi [GO:0033578]; protein maturation [GO:0051604]; protein secretion [GO:0009306]; regulation of cholesterol metabolic process [GO:0090181]; regulation of triglyceride metabolic process [GO:0090207]; triglyceride metabolic process [GO:0006641] GO:0005789; GO:0005794; GO:0006641; GO:0006888; GO:0009306; GO:0016021; GO:0033578; GO:0034382; GO:0051006; GO:0051604; GO:0090181; GO:0090207 0 0 0 PF06762; Q3U487 CHOYP_BRAFLDRAFT_276868.1.1 m.27780 sp HECD3_MOUSE 44.291 867 423 13 13 837 9 857 0 753 HECD3_MOUSE reviewed E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3) Hectd3 Mus musculus (Mouse) 861 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0016874; GO:0019905; GO:0042787; GO:0043161; GO:0048471 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF00632; Q3UDE2 CHOYP_TTL12.1.1 m.6226 sp TTL12_MOUSE 50.317 630 267 10 28 626 25 639 0 621 TTL12_MOUSE reviewed Tubulin--tyrosine ligase-like protein 12 Ttll12 Mus musculus (Mouse) 639 cellular protein modification process [GO:0006464] GO:0005524; GO:0006464 0 0 0 PF03133; Q3UGF1 CHOYP_LOC100368525.1.1 m.62480 sp WDR19_MOUSE 66.097 1345 447 7 1 1342 1 1339 0 1922 WDR19_MOUSE reviewed WD repeat-containing protein 19 Wdr19 Kiaa1638 Mus musculus (Mouse) 1341 cell morphogenesis [GO:0000902]; ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; digestive system development [GO:0055123]; ear morphogenesis [GO:0042471]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; gonad development [GO:0008406]; intraciliary retrograde transport [GO:0035721]; in utero embryonic development [GO:0001701]; myotome development [GO:0061055]; neurological system process [GO:0050877]; protein localization to cilium [GO:0061512]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831] GO:0000902; GO:0001701; GO:0001750; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0005929; GO:0007224; GO:0008406; GO:0030326; GO:0030991; GO:0031076; GO:0031513; GO:0031514; GO:0032391; GO:0035721; GO:0042384; GO:0042471; GO:0048701; GO:0050877; GO:0055123; GO:0060271; GO:0060830; GO:0060831; GO:0061055; GO:0061512 0 0 0 0 Q3UHC7 CHOYP_NGAP.1.2 m.19887 sp DAB2P_MOUSE 45.483 631 304 10 217 845 68 660 0 587 DAB2P_MOUSE reviewed Disabled homolog 2-interacting protein (DAB2-interacting protein) (ASK-interacting protein 1) (DOC-2/DAB-2 interactive protein) Dab2ip Kiaa1743 Mus musculus (Mouse) 1189 "activation of JUN kinase activity [GO:0007257]; activation of MAPKKK activity [GO:0000185]; angiogenesis [GO:0001525]; cell cycle [GO:0007049]; cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; cellular protein catabolic process [GO:0044257]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; layer formation in cerebral cortex [GO:0021819]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catenin import into nucleus [GO:0035414]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cyclin catabolic process [GO:2000599]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of GTPase activity [GO:0034260]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; neuron projection morphogenesis [GO:0048812]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of synapse maturation [GO:0090129]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; reelin-mediated signaling pathway [GO:0038026]; regulation of growth [GO:0040008]; regulation of GTPase activity [GO:0043087]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein complex assembly [GO:0043254]; regulation of protein heterodimerization activity [GO:0043497]; response to unfolded protein [GO:0006986]; tube formation [GO:0035148]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]" GO:0000122; GO:0000185; GO:0001525; GO:0001933; GO:0005096; GO:0005123; GO:0005737; GO:0005886; GO:0006954; GO:0006986; GO:0007049; GO:0007252; GO:0007257; GO:0008285; GO:0008625; GO:0010596; GO:0010633; GO:0010719; GO:0010976; GO:0014067; GO:0016525; GO:0017124; GO:0019900; GO:0019901; GO:0021814; GO:0021819; GO:0030139; GO:0030424; GO:0030425; GO:0030948; GO:0031235; GO:0031434; GO:0031435; GO:0032088; GO:0032266; GO:0032403; GO:0032809; GO:0034144; GO:0034260; GO:0035148; GO:0035414; GO:0035591; GO:0035924; GO:0036312; GO:0036324; GO:0038026; GO:0040008; GO:0042802; GO:0042803; GO:0043025; GO:0043065; GO:0043087; GO:0043122; GO:0043124; GO:0043184; GO:0043254; GO:0043407; GO:0043410; GO:0043497; GO:0043507; GO:0043548; GO:0043553; GO:0044257; GO:0044300; GO:0044301; GO:0045087; GO:0045732; GO:0045892; GO:0045944; GO:0046330; GO:0046580; GO:0048147; GO:0048812; GO:0050679; GO:0050680; GO:0051721; GO:0070059; GO:0070062; GO:0070273; GO:0070317; GO:0070373; GO:0071158; GO:0071222; GO:0071347; GO:0071356; GO:0071889; GO:0071901; GO:0071902; GO:0090090; GO:0090129; GO:1900006; GO:1900744; GO:1900747; GO:1901800; GO:1990032; GO:1990597; GO:2000599; GO:2001224; GO:2001235 0 0 0 PF00168;PF12004;PF00616; Q3UHC7 CHOYP_NGAP.2.2 m.63455 sp DAB2P_MOUSE 45.483 631 304 10 174 802 68 660 0 587 DAB2P_MOUSE reviewed Disabled homolog 2-interacting protein (DAB2-interacting protein) (ASK-interacting protein 1) (DOC-2/DAB-2 interactive protein) Dab2ip Kiaa1743 Mus musculus (Mouse) 1189 "activation of JUN kinase activity [GO:0007257]; activation of MAPKKK activity [GO:0000185]; angiogenesis [GO:0001525]; cell cycle [GO:0007049]; cell motility involved in cerebral cortex radial glia guided migration [GO:0021814]; cellular protein catabolic process [GO:0044257]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; layer formation in cerebral cortex [GO:0021819]; negative regulation of angiogenesis [GO:0016525]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catenin import into nucleus [GO:0035414]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cyclin catabolic process [GO:2000599]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of GTPase activity [GO:0034260]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; neuron projection morphogenesis [GO:0048812]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of dendrite development [GO:1900006]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of synapse maturation [GO:0090129]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; reelin-mediated signaling pathway [GO:0038026]; regulation of growth [GO:0040008]; regulation of GTPase activity [GO:0043087]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein complex assembly [GO:0043254]; regulation of protein heterodimerization activity [GO:0043497]; response to unfolded protein [GO:0006986]; tube formation [GO:0035148]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]" GO:0000122; GO:0000185; GO:0001525; GO:0001933; GO:0005096; GO:0005123; GO:0005737; GO:0005886; GO:0006954; GO:0006986; GO:0007049; GO:0007252; GO:0007257; GO:0008285; GO:0008625; GO:0010596; GO:0010633; GO:0010719; GO:0010976; GO:0014067; GO:0016525; GO:0017124; GO:0019900; GO:0019901; GO:0021814; GO:0021819; GO:0030139; GO:0030424; GO:0030425; GO:0030948; GO:0031235; GO:0031434; GO:0031435; GO:0032088; GO:0032266; GO:0032403; GO:0032809; GO:0034144; GO:0034260; GO:0035148; GO:0035414; GO:0035591; GO:0035924; GO:0036312; GO:0036324; GO:0038026; GO:0040008; GO:0042802; GO:0042803; GO:0043025; GO:0043065; GO:0043087; GO:0043122; GO:0043124; GO:0043184; GO:0043254; GO:0043407; GO:0043410; GO:0043497; GO:0043507; GO:0043548; GO:0043553; GO:0044257; GO:0044300; GO:0044301; GO:0045087; GO:0045732; GO:0045892; GO:0045944; GO:0046330; GO:0046580; GO:0048147; GO:0048812; GO:0050679; GO:0050680; GO:0051721; GO:0070059; GO:0070062; GO:0070273; GO:0070317; GO:0070373; GO:0071158; GO:0071222; GO:0071347; GO:0071356; GO:0071889; GO:0071901; GO:0071902; GO:0090090; GO:0090129; GO:1900006; GO:1900744; GO:1900747; GO:1901800; GO:1990032; GO:1990597; GO:2000599; GO:2001224; GO:2001235 0 0 0 PF00168;PF12004;PF00616; Q3ULD5 CHOYP_BRAFLDRAFT_266349.1.1 m.9217 sp MCCB_MOUSE 74.081 544 140 1 19 561 20 563 0 855 MCCB_MOUSE reviewed "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)" Mccc2 Mus musculus (Mouse) 563 coenzyme A metabolic process [GO:0015936]; leucine catabolic process [GO:0006552] GO:0004485; GO:0005524; GO:0005739; GO:0005759; GO:0006552; GO:0015936 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. 0 0 PF01039; Q3UMM4 CHOYP_CDK10.1.1 m.35897 sp CDK10_MOUSE 72.434 341 91 1 21 361 21 358 0 514 CDK10_MOUSE reviewed Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) Cdk10 Mus musculus (Mouse) 360 positive regulation of MAPK cascade [GO:0043410] GO:0004693; GO:0005524; GO:0005622; GO:0005634; GO:0043410; GO:0097472 0 0 0 PF00069; Q3UNX5 CHOYP_ACSM3.1.1 m.23686 sp ACSM3_MOUSE 50.947 581 273 6 4 583 8 577 0 630 ACSM3_MOUSE reviewed "Acyl-coenzyme A synthetase ACSM3, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 3) (Butyrate--CoA ligase 3) (Butyryl-coenzyme A synthetase 3) (Middle-chain acyl-CoA synthetase 3) (Protein SA homolog)" Acsm3 Sa Sah Mus musculus (Mouse) 580 fatty acid biosynthetic process [GO:0006633] GO:0005524; GO:0005739; GO:0005759; GO:0006633; GO:0015645; GO:0046872; GO:0047760 0 0 0 PF00501;PF13193; Q3UQN2 CHOYP_FCHO2.1.1 m.46242 sp FCHO2_MOUSE 41.713 899 411 14 1 879 3 808 0 647 FCHO2_MOUSE reviewed F-BAR domain only protein 2 Fcho2 Mus musculus (Mouse) 809 clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659] GO:0001786; GO:0005546; GO:0005886; GO:0005905; GO:0010324; GO:0030136; GO:0035091; GO:0048268; GO:0072583; GO:0072659 0 0 0 PF00611;PF10291; Q3UQN2 CHOYP_LOC100123907.1.1 m.2986 sp FCHO2_MOUSE 42.452 881 414 15 5 865 1 808 0 649 FCHO2_MOUSE reviewed F-BAR domain only protein 2 Fcho2 Mus musculus (Mouse) 809 clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; membrane invagination [GO:0010324]; protein localization to plasma membrane [GO:0072659] GO:0001786; GO:0005546; GO:0005886; GO:0005905; GO:0010324; GO:0030136; GO:0035091; GO:0048268; GO:0072583; GO:0072659 0 0 0 PF00611;PF10291; Q3UVG3 CHOYP_F91A1.1.1 m.52980 sp F91A1_MOUSE 56.446 861 322 13 1 844 1 825 0 964 F91A1_MOUSE reviewed Protein FAM91A1 Fam91a1 D15Ertd621e Kiaa0493 Mus musculus (Mouse) 837 0 0 0 0 0 PF14648;PF14647; Q3UVX5 CHOYP_GRM1.1.2 m.48217 sp GRM5_MOUSE 48.154 596 296 8 20 611 19 605 0 582 GRM5_MOUSE reviewed Metabotropic glutamate receptor 5 (mGluR5) Grm5 Gprc1e Mglur5 Mus musculus (Mouse) 1203 "cognition [GO:0050890]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0001639; GO:0004930; GO:0005737; GO:0005886; GO:0005887; GO:0007205; GO:0007216; GO:0007612; GO:0007626; GO:0008066; GO:0014069; GO:0043005; GO:0048169; GO:0050890; GO:0051966; GO:0070062 0 0 0 PF00003;PF01094;PF10606;PF07562; Q3UVY5 CHOYP_LOC100376367.1.1 m.31877 sp PCX4_MOUSE 40.993 1249 636 24 1 1226 1 1171 0 860 PCX4_MOUSE reviewed Pecanex-like protein 4 (Pecanex homolog protein 4) Pcnx4 Pcnxl4 Mus musculus (Mouse) 1174 0 GO:0016021 0 0 0 PF05041; Q3UWM4 CHOYP_BRAFLDRAFT_119367.1.1 m.59963 sp KDM7A_MOUSE 39.203 954 502 19 12 944 38 934 0 629 KDM7A_MOUSE reviewed Lysine-specific demethylase 7A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) Kdm7a Jhdm1d Kdm7 Kiaa1718 Mus musculus (Mouse) 940 "histone H3-K27 demethylation [GO:0071557]; histone H3-K36 demethylation [GO:0070544]; histone H3-K9 demethylation [GO:0033169]; histone H4-K20 demethylation [GO:0035574]; midbrain development [GO:0030901]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0005506; GO:0005654; GO:0005730; GO:0006351; GO:0008270; GO:0016706; GO:0030901; GO:0032454; GO:0033169; GO:0035064; GO:0035574; GO:0035575; GO:0045893; GO:0051864; GO:0070544; GO:0071557; GO:0071558 0 0 0 PF02373;PF00628; Q3UY96 CHOYP_LOC100368636.1.1 m.6631 sp CFA74_MOUSE 40.231 1643 837 22 66 1695 66 1576 0 1146 CFA74_MOUSE reviewed Cilia- and flagella-associated protein 74 Cfap74 Mus musculus (Mouse) 1578 axoneme assembly [GO:0035082] GO:0005737; GO:0005930; GO:0035082 0 0 0 0 Q3V6T2 CHOYP_GRDN.1.5 m.12675 sp GRDN_HUMAN 41.338 1420 773 18 7 1384 13 1414 0 936 GRDN_HUMAN reviewed Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) CCDC88A APE GRDN KIAA1212 Homo sapiens (Human) 1871 activation of protein kinase B activity [GO:0032148]; cell migration [GO:0016477]; DNA replication [GO:0006260]; lamellipodium assembly [GO:0030032]; membrane organization [GO:0061024]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell proliferation [GO:0042127]; regulation of DNA replication [GO:0006275]; regulation of neuron projection development [GO:0010975]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] GO:0001932; GO:0003779; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006260; GO:0006275; GO:0008017; GO:0010975; GO:0016020; GO:0016023; GO:0016477; GO:0030027; GO:0030032; GO:0031410; GO:0031929; GO:0032148; GO:0032956; GO:0035091; GO:0042127; GO:0042803; GO:0043422; GO:0061024 0 0 0 PF05622; Q3V6T2 CHOYP_GRDN.4.5 m.59842 sp GRDN_HUMAN 37.127 1810 1011 37 7 1732 13 1779 0 933 GRDN_HUMAN reviewed Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) CCDC88A APE GRDN KIAA1212 Homo sapiens (Human) 1871 activation of protein kinase B activity [GO:0032148]; cell migration [GO:0016477]; DNA replication [GO:0006260]; lamellipodium assembly [GO:0030032]; membrane organization [GO:0061024]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell proliferation [GO:0042127]; regulation of DNA replication [GO:0006275]; regulation of neuron projection development [GO:0010975]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] GO:0001932; GO:0003779; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006260; GO:0006275; GO:0008017; GO:0010975; GO:0016020; GO:0016023; GO:0016477; GO:0030027; GO:0030032; GO:0031410; GO:0031929; GO:0032148; GO:0032956; GO:0035091; GO:0042127; GO:0042803; GO:0043422; GO:0061024 0 0 0 PF05622; Q3V6T2 CHOYP_GRDN.5.5 m.59844 sp GRDN_HUMAN 41.338 1420 773 18 7 1384 13 1414 0 933 GRDN_HUMAN reviewed Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1) CCDC88A APE GRDN KIAA1212 Homo sapiens (Human) 1871 activation of protein kinase B activity [GO:0032148]; cell migration [GO:0016477]; DNA replication [GO:0006260]; lamellipodium assembly [GO:0030032]; membrane organization [GO:0061024]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell proliferation [GO:0042127]; regulation of DNA replication [GO:0006275]; regulation of neuron projection development [GO:0010975]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] GO:0001932; GO:0003779; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006260; GO:0006275; GO:0008017; GO:0010975; GO:0016020; GO:0016023; GO:0016477; GO:0030027; GO:0030032; GO:0031410; GO:0031929; GO:0032148; GO:0032956; GO:0035091; GO:0042127; GO:0042803; GO:0043422; GO:0061024 0 0 0 PF05622; Q3YK19 CHOYP_FANCJ.1.1 m.17513 sp FANCJ_CHICK 41.249 977 475 18 9 905 10 967 0 723 FANCJ_CHICK reviewed Fanconi anemia group J protein homolog (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) BRIP1 FANCJ Gallus gallus (Chicken) 1252 DNA repair [GO:0006281]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0003677; GO:0003678; GO:0004003; GO:0005524; GO:0005654; GO:0005737; GO:0006281; GO:0006357; GO:0031965; GO:0046872; GO:0051539 0 0 0 PF06733;PF13307; Q3ZBD7 CHOYP_LOC100366799.1.2 m.37253 sp G6PI_BOVIN 71.038 549 158 1 20 567 2 550 0 840 G6PI_BOVIN reviewed Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) GPI Bos taurus (Bovine) 557 angiogenesis [GO:0001525]; erythrocyte homeostasis [GO:0034101]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707] GO:0001525; GO:0001701; GO:0001707; GO:0004347; GO:0005615; GO:0005654; GO:0005737; GO:0006094; GO:0006096; GO:0034101; GO:0042593; GO:0043209; GO:0060170; GO:0070062 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. 0 0 PF00342; Q3ZBH0 CHOYP_TCPB.1.1 m.6398 sp TCPB_BOVIN 78.491 530 111 1 2 528 4 533 0 839 TCPB_BOVIN reviewed T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) CCT2 Bos taurus (Bovine) 535 binding of sperm to zona pellucida [GO:0007339]; chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]; toxin transport [GO:1901998] GO:0002199; GO:0005524; GO:0005832; GO:0005874; GO:0006457; GO:0007339; GO:0043209; GO:0044297; GO:0051131; GO:0070062; GO:1901998 0 0 cd03336; PF00118; Q3ZBV2 CHOYP_DD19A.1.1 m.57641 sp DD19A_BOVIN 65.796 421 143 1 153 573 59 478 0 605 DD19A_BOVIN reviewed ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DEAD box protein 19A) DDX19A Bos taurus (Bovine) 478 mRNA export from nucleus [GO:0006406]; protein transport [GO:0015031]; RNA secondary structure unwinding [GO:0010501] GO:0003723; GO:0004004; GO:0005524; GO:0005643; GO:0005737; GO:0006406; GO:0010501; GO:0015031; GO:0031965 0 0 0 PF00270;PF00271; Q3ZC89 CHOYP_BRAFLDRAFT_127105.1.1 m.21922 sp MAP2_BOVIN 77.358 371 84 0 617 987 107 477 0 619 MAP2_BOVIN reviewed Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) METAP2 Bos taurus (Bovine) 477 protein initiator methionine removal [GO:0070084] GO:0005737; GO:0046872; GO:0070006; GO:0070084 0 0 cd01088; PF00557; Q3ZCH0 CHOYP_GRP75.1.1 m.11678 sp GRP75_BOVIN 77.778 657 127 4 44 700 41 678 0 1056 GRP75_BOVIN reviewed "Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9)" HSPA9 Bos taurus (Bovine) 679 erythrocyte differentiation [GO:0030218]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; negative regulation of hemopoiesis [GO:1903707]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457] GO:0005524; GO:0005730; GO:0005925; GO:0006457; GO:0006611; GO:0030218; GO:0042645; GO:0043209; GO:0044822; GO:0045647; GO:0070062; GO:1902037; GO:1903707 0 0 0 PF00012; Q460N5 CHOYP_BRAFLDRAFT_74874.2.9 m.32476 sp PAR14_HUMAN 27.897 1631 1093 33 2 1611 232 1800 0 622 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q460N5 CHOYP_BRAFLDRAFT_74879.3.6 m.24658 sp PAR14_HUMAN 27.479 1896 1231 45 593 2458 19 1800 0 629 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q460N5 CHOYP_BRAFLDRAFT_84838.2.6 m.32877 sp PAR14_HUMAN 27.027 1887 1240 43 592 2447 20 1800 0 614 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q495T6 CHOYP_LOC100118995.1.1 m.41166 sp MMEL1_HUMAN 42.734 695 378 9 90 765 86 779 0 599 MMEL1_HUMAN reviewed "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) 779 0 GO:0004222; GO:0005576; GO:0016021; GO:0046872 0 0 cd08662; PF01431;PF05649; Q495T6 CHOYP_LOC660501.1.2 m.5218 sp MMEL1_HUMAN 40.143 700 396 10 101 784 87 779 0 543 MMEL1_HUMAN reviewed "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) 779 0 GO:0004222; GO:0005576; GO:0016021; GO:0046872 0 0 cd08662; PF01431;PF05649; Q495T6 CHOYP_LOC660501.2.2 m.19155 sp MMEL1_HUMAN 40.057 699 398 9 86 769 87 779 0 542 MMEL1_HUMAN reviewed "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) 779 0 GO:0004222; GO:0005576; GO:0016021; GO:0046872 0 0 cd08662; PF01431;PF05649; Q498E7 CHOYP_SMARCAL1.1.1 m.54933 sp SMAL1_XENLA 54.211 570 250 9 171 732 355 921 0 608 SMAL1_XENLA reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (Sucrose nonfermenting protein 2-like 1) smarcal1 harp Xenopus laevis (African clawed frog) 960 DNA metabolic process [GO:0006259]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0004386; GO:0005524; GO:0005634; GO:0006259; GO:0006357; GO:0008094; GO:0036310 0 0 0 PF07443;PF00271;PF00176; Q49GP5 CHOYP_LOC655570.1.2 m.9210 sp P4K2B_DANRE 69.388 392 106 5 48 431 116 501 0 561 P4K2B_DANRE reviewed Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) pi4k2b zgc:158305 Danio rerio (Zebrafish) (Brachydanio rerio) 501 pectoral fin development [GO:0033339] GO:0004430; GO:0005524; GO:0005737; GO:0016020; GO:0033339 0 0 0 PF00454; Q4AC94 CHOYP_LOC576341.1.2 m.9414 sp C2CD3_HUMAN 34.28 1444 758 37 2 1390 620 1927 0 779 C2CD3_HUMAN reviewed C2 domain-containing protein 3 C2CD3 Homo sapiens (Human) 2353 brain development [GO:0007420]; centriole elongation [GO:0061511]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; nonmotile primary cilium assembly [GO:0035058]; protein localization to centrosome [GO:0071539]; protein processing [GO:0016485]; regulation of proteolysis [GO:0030162]; regulation of smoothened signaling pathway [GO:0008589] GO:0001701; GO:0001947; GO:0005813; GO:0005814; GO:0005829; GO:0007420; GO:0008589; GO:0016485; GO:0021915; GO:0021997; GO:0030162; GO:0034451; GO:0035058; GO:0036064; GO:0042733; GO:0061511; GO:0071539 0 0 0 PF00168; Q4G0P3 CHOYP_LOC100375784.1.6 m.4720 sp HYDIN_HUMAN 39.324 1480 766 31 923 2356 1317 2710 0 949 HYDIN_HUMAN reviewed Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) 5121 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780; Q4G0P3 CHOYP_LOC100375784.2.6 m.7640 sp HYDIN_HUMAN 42.173 3967 2034 63 1367 5235 1317 5121 0 3097 HYDIN_HUMAN reviewed Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) 5121 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780; Q4G0P3 CHOYP_LOC100375784.3.6 m.12285 sp HYDIN_HUMAN 41.975 3626 1877 58 3 3527 1622 5121 0 2824 HYDIN_HUMAN reviewed Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) 5121 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780; Q4G0P3 CHOYP_LOC100375784.4.6 m.27594 sp HYDIN_HUMAN 42.828 5333 2713 75 26 5257 24 5121 0 4253 HYDIN_HUMAN reviewed Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) 5121 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780; Q4G0P3 CHOYP_LOC100375784.5.6 m.48393 sp HYDIN_HUMAN 41.733 5147 2625 76 1 5054 256 5121 0 3960 HYDIN_HUMAN reviewed Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) 5121 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780; Q4G0P3 CHOYP_LOC100375784.6.6 m.50541 sp HYDIN_HUMAN 41.633 3711 1924 58 5 3642 1580 5121 0 2858 HYDIN_HUMAN reviewed Hydrocephalus-inducing protein homolog HYDIN HYDIN1 KIAA1864 Homo sapiens (Human) 5121 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780; Q4G0U5 CHOYP_LOC100367352.1.1 m.27863 sp PCDP1_HUMAN 38.698 814 452 16 34 836 32 809 0 564 PCDP1_HUMAN reviewed Cilia- and flagella-associated protein 221 (Primary ciliary dyskinesia protein 1) CFAP221 PCDP1 Homo sapiens (Human) 840 cilium morphogenesis [GO:0060271]; cilium movement [GO:0003341] GO:0003341; GO:0005516; GO:0005737; GO:0005929; GO:0005930; GO:0060271 0 0 0 0 Q4G0X9 CHOYP_LOC100374249.1.1 m.58296 sp CCD40_HUMAN 37.817 1063 626 8 81 1138 105 1137 0 679 CCD40_HUMAN reviewed Coiled-coil domain-containing protein 40 CCDC40 KIAA1640 Homo sapiens (Human) 1142 axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; epithelial cilium movement [GO:0003351]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; lung development [GO:0030324]; motile cilium assembly [GO:0044458]; regulation of cilium beat frequency [GO:0003356]; sperm motility [GO:0030317] GO:0001947; GO:0003341; GO:0003351; GO:0003356; GO:0005737; GO:0005929; GO:0005930; GO:0030317; GO:0030324; GO:0035469; GO:0036159; GO:0044458; GO:0060287; GO:0070286; GO:0071907; GO:0071910 0 0 0 PF08647; Q4GZT3 CHOYP_PKD2.1.3 m.12169 sp PKD2_BOVIN 52.964 759 338 7 75 830 194 936 0 771 PKD2_BOVIN reviewed Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2) PKD2 TRPP2 Bos taurus (Bovine) 970 "aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell cycle arrest [GO:0007050]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; heart looping [GO:0001947]; JAK-STAT cascade [GO:0007259]; mesonephric duct development [GO:0072177]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric smooth muscle tissue development [GO:0072208]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cAMP metabolic process [GO:0030814]; regulation of cell proliferation [GO:0042127]; renal artery morphogenesis [GO:0061441]; spinal cord development [GO:0021510]" GO:0001658; GO:0001892; GO:0001947; GO:0002133; GO:0003127; GO:0005245; GO:0005248; GO:0005262; GO:0005267; GO:0005509; GO:0005887; GO:0005911; GO:0007050; GO:0007259; GO:0009925; GO:0016020; GO:0021510; GO:0021915; GO:0030027; GO:0030814; GO:0031512; GO:0031513; GO:0031587; GO:0031659; GO:0031941; GO:0035502; GO:0035904; GO:0036064; GO:0042127; GO:0042994; GO:0045180; GO:0045429; GO:0045944; GO:0048763; GO:0050982; GO:0060170; GO:0060315; GO:0060674; GO:0061441; GO:0070062; GO:0071158; GO:0071458; GO:0071464; GO:0071470; GO:0071498; GO:0071556; GO:0071910; GO:0072075; GO:0072177; GO:0072208; GO:0072214; GO:0072218; GO:0072219; GO:0072235; GO:0072284; GO:0072686; GO:2000134 0 0 0 PF08016; Q4GZT3 CHOYP_PKD2.2.3 m.49514 sp PKD2_BOVIN 51.465 785 336 8 75 856 194 936 0 762 PKD2_BOVIN reviewed Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2) PKD2 TRPP2 Bos taurus (Bovine) 970 "aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell cycle arrest [GO:0007050]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; heart looping [GO:0001947]; JAK-STAT cascade [GO:0007259]; mesonephric duct development [GO:0072177]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric smooth muscle tissue development [GO:0072208]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cAMP metabolic process [GO:0030814]; regulation of cell proliferation [GO:0042127]; renal artery morphogenesis [GO:0061441]; spinal cord development [GO:0021510]" GO:0001658; GO:0001892; GO:0001947; GO:0002133; GO:0003127; GO:0005245; GO:0005248; GO:0005262; GO:0005267; GO:0005509; GO:0005887; GO:0005911; GO:0007050; GO:0007259; GO:0009925; GO:0016020; GO:0021510; GO:0021915; GO:0030027; GO:0030814; GO:0031512; GO:0031513; GO:0031587; GO:0031659; GO:0031941; GO:0035502; GO:0035904; GO:0036064; GO:0042127; GO:0042994; GO:0045180; GO:0045429; GO:0045944; GO:0048763; GO:0050982; GO:0060170; GO:0060315; GO:0060674; GO:0061441; GO:0070062; GO:0071158; GO:0071458; GO:0071464; GO:0071470; GO:0071498; GO:0071556; GO:0071910; GO:0072075; GO:0072177; GO:0072208; GO:0072214; GO:0072218; GO:0072219; GO:0072235; GO:0072284; GO:0072686; GO:2000134 0 0 0 PF08016; Q4JIJ3 CHOYP_METH.1.1 m.18095 sp METH_BOVIN 69.407 1265 375 5 1 1254 1 1264 0 1871 METH_BOVIN reviewed Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS) MTR Bos taurus (Bovine) 1265 pteridine-containing compound metabolic process [GO:0042558] GO:0005829; GO:0008270; GO:0008705; GO:0008898; GO:0031419; GO:0042558 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1. 0 cd02069; PF02310;PF02607;PF02965;PF00809;PF02574; Q4KTY1 CHOYP_KPSH1.1.1 m.29996 sp KPSH1_PINFU 83.532 419 55 7 1 409 1 415 0 715 KPSH1_PINFU reviewed Serine/threonine-protein kinase H1 homolog (EC 2.7.11.1) PSKH1 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 415 0 GO:0004674; GO:0005524 0 0 0 PF00069; Q4QQW3 CHOYP_LOC100691144.1.1 m.47006 sp HOT_RAT 63.699 438 156 1 31 468 33 467 0 571 HOT_RAT reviewed "Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (EC 1.1.99.24) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1)" Adhfe1 Rattus norvegicus (Rat) 467 molecular hydrogen transport [GO:0015993] GO:0005739; GO:0015993; GO:0016616; GO:0046872; GO:0047988 0 0 0 PF00465; Q4QQW8 CHOYP_BRAFLDRAFT_287019.1.1 m.36911 sp PLBL2_RAT 49.719 533 250 9 21 541 54 580 0 528 PLBL2_RAT reviewed Putative phospholipase B-like 2 (EC 3.1.1.-) (LAMA-like protein 2) (Lamina ancestor homolog 2) (Phospholipase B domain-containing protein 2) Plbd2 RDCR-0918-3 Rattus norvegicus (Rat) 585 lipid catabolic process [GO:0016042] GO:0016042; GO:0016787; GO:0043202; GO:0070062 0 0 0 PF04916; Q4QQY7 CHOYP_LOC100367470.1.1 m.51904 sp TGT_XENLA 63.384 396 144 1 1 395 1 396 0 561 TGT_XENLA reviewed Queuine tRNA-ribosyltransferase catalytic subunit (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) qtrt1 Xenopus laevis (African clawed frog) 396 queuosine biosynthetic process [GO:0008616]; tRNA modification [GO:0006400] GO:0006400; GO:0008479; GO:0008616; GO:0042803; GO:0046872; GO:0046982 PATHWAY: tRNA modification; tRNA-queuosine biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03218}. 0 0 PF01702; Q4QR29 CHOYP_CTR9.1.1 m.18832 sp CTR9_XENLA 66.003 1156 351 11 3 1133 4 1142 0 1508 CTR9_XENLA reviewed RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) ctr9 sh2bp1 Xenopus laevis (African clawed frog) 1157 "histone H3-K4 trimethylation [GO:0080182]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0006351; GO:0016593; GO:0032968; GO:0035327; GO:0045944; GO:0051571; GO:0080182 0 0 0 PF13181; Q4QRK0 CHOYP_BRAFLDRAFT_59647.1.1 m.25700 sp MAP11_DANRE 68.895 389 109 3 26 405 1 386 0 565 MAP11_DANRE reviewed Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1) metap1 Danio rerio (Zebrafish) (Brachydanio rerio) 386 protein initiator methionine removal [GO:0070084] GO:0022626; GO:0046872; GO:0070006; GO:0070084 0 0 cd01086; PF00557;PF15801; Q4R367 CHOYP_UFL1.1.1 m.20000 sp UFL1_MACFA 44.969 805 404 11 25 802 1 793 0 709 UFL1_MACFA reviewed E3 UFM1-protein ligase 1 (EC 6.3.2.-) UFL1 QtsA-19276 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 793 negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein ubiquitination [GO:0031397]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146] GO:0005737; GO:0005783; GO:0005829; GO:0016874; GO:0031397; GO:0032088; GO:0033146; GO:0071568; GO:0071569; GO:1990592 0 0 0 PF09743; Q4R4R0 CHOYP_PRS7.1.1 m.31825 sp PRS7_MACFA 92.841 433 31 0 1 433 1 433 0 839 PRS7_MACFA reviewed 26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) PSMC2 QnpA-16482 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 433 ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000502; GO:0000932; GO:0005524; GO:0005634; GO:0006511; GO:0016887; GO:0022624 0 0 0 PF00004; Q4R4U1 CHOYP_BRAFLDRAFT_72760.1.1 m.11536 sp PANK4_MACFA 55.497 764 327 6 8 768 18 771 0 883 PANK4_MACFA reviewed Pantothenate kinase 4 (EC 2.7.1.33) (Pantothenic acid kinase 4) PANK4 QccE-17245 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 773 coenzyme A biosynthetic process [GO:0015937] GO:0004594; GO:0005524; GO:0005737; GO:0015937 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. 0 0 PF01937;PF03630; Q4R502 CHOYP_BRAFLDRAFT_115608.1.1 m.25984 sp IDHP_MACFA 74.707 427 100 4 52 471 22 447 0 675 IDHP_MACFA reviewed "Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)" IDH2 QnpA-13564 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 452 2-oxoglutarate metabolic process [GO:0006103]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] GO:0000287; GO:0004450; GO:0005739; GO:0006097; GO:0006099; GO:0006102; GO:0006103; GO:0051287 0 0 0 PF00180; Q4R550 CHOYP_MYSP.5.9 m.28125 sp SYCC_MACFA 62.842 732 258 6 47 765 9 739 0 958 SYCC_MACFA reviewed "Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)" CARS QccE-19031 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 748 cysteinyl-tRNA aminoacylation [GO:0006423] GO:0000049; GO:0004817; GO:0005524; GO:0005737; GO:0006423; GO:0046872 0 0 cd00672; PF01406; Q4R562 CHOYP_ARRB.1.2 m.25932 sp ARRB1_MACFA 62.712 413 136 6 8 419 2 397 0 517 ARRB1_MACFA reviewed Beta-arrestin-1 (Arrestin beta-1) ARRB1 QccE-17776 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 410 "negative regulation of signal transduction [GO:0009968]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0001934; GO:0002092; GO:0005634; GO:0005886; GO:0005905; GO:0006351; GO:0006355; GO:0007165; GO:0009968; GO:0015031; GO:0016023; GO:0031143 0 0 0 PF02752;PF00339; Q4R5S7 CHOYP_LOC100370637.1.2 m.12891 sp DDX4_MACFA 48.338 722 294 18 80 777 59 725 0 580 DDX4_MACFA reviewed Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog) DDX4 QtsA-21246 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 725 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0003676; GO:0004386; GO:0005524; GO:0005737; GO:0007140; GO:0007275; GO:0007283; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:0048471; GO:0071546; GO:0071547 0 0 0 PF00270;PF00271; Q4R628 CHOYP_KIF3A.1.1 m.51746 sp KIF3A_MACFA 72.214 691 186 4 7 695 9 695 0 1009 KIF3A_MACFA reviewed Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A) KIF3A QtsA-19288 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 702 cilium assembly [GO:0042384]; microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0042384; GO:0072372 0 0 0 PF00225; Q4R6T7 CHOYP_LOC100375473.1.1 m.9062 sp IQUB_MACFA 55.486 638 281 2 229 866 127 761 0 717 IQUB_MACFA reviewed IQ and ubiquitin-like domain-containing protein IQUB QtsA-17155 QtsA-17428 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 790 cell projection organization [GO:0030030] GO:0030030 0 0 0 0 Q4R6V2 CHOYP_BRAFLDRAFT_124069.1.1 m.14145 sp TCPE_MACFA 75.472 530 130 0 3 532 5 534 0 853 TCPE_MACFA reviewed T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) CCT5 QtsA-17059 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 541 protein folding [GO:0006457] GO:0005524; GO:0005815; GO:0005832; GO:0006457; GO:0031681 0 0 cd03339; PF00118; Q4R779 CHOYP_NOL5.1.1 m.49429 sp NOP58_MACFA 69.866 448 134 1 1 448 1 447 0 640 NOP58_MACFA reviewed Nucleolar protein 58 (Nucleolar protein 5) NOP58 NOL5 QtsA-15965 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 530 ribosome biogenesis [GO:0042254] GO:0005654; GO:0005730; GO:0030529; GO:0042254 0 0 0 PF01798;PF08156; Q4R7L3 CHOYP_PRS6B.1.1 m.66735 sp PRS6B_MACFA 88.095 420 46 2 18 435 1 418 0 753 PRS6B_MACFA reviewed 26S protease regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4) PSMC4 QtsA-14940 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 418 protein catabolic process [GO:0030163] GO:0005524; GO:0005634; GO:0005737; GO:0016787; GO:0022624; GO:0030163 0 0 0 PF00004; Q4TVV3 CHOYP_DDX46.1.1 m.52473 sp DDX46_DANRE 65.673 906 274 9 122 993 116 1018 0 1179 DDX46_DANRE reviewed Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) ddx46 Danio rerio (Zebrafish) (Brachydanio rerio) 1018 "brain development [GO:0007420]; definitive hemopoiesis [GO:0060216]; digestive tract morphogenesis [GO:0048546]; exocrine pancreas development [GO:0031017]; liver morphogenesis [GO:0072576]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of hematopoietic stem cell differentiation [GO:1902038]; positive regulation of lymphocyte differentiation [GO:0045621]; regulation of gene expression [GO:0010468]; RNA secondary structure unwinding [GO:0010501]" GO:0000398; GO:0003723; GO:0004004; GO:0005524; GO:0007420; GO:0010468; GO:0010501; GO:0015030; GO:0016607; GO:0031017; GO:0045621; GO:0045648; GO:0048546; GO:0060216; GO:0072576; GO:1902038 0 0 0 PF00270;PF00271; Q4V7Y7 CHOYP_BRAFLDRAFT_128944.2.2 m.37986 sp KTNB1_XENLA 48.872 665 294 11 2 634 5 655 0 657 KTNB1_XENLA reviewed Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) katnb1 Xenopus laevis (African clawed frog) 655 cell division [GO:0051301]; microtubule severing [GO:0051013]; mitotic nuclear division [GO:0007067] GO:0000922; GO:0005813; GO:0005874; GO:0007067; GO:0008352; GO:0051013; GO:0051301 0 0 0 PF13925;PF00400; Q4V8G4 CHOYP_LOC574740.1.1 m.29924 sp WDR78_RAT 42.754 835 387 15 17 809 12 797 0 626 WDR78_RAT reviewed WD repeat-containing protein 78 Wdr78 Rattus norvegicus (Rat) 803 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244 0 0 0 PF00400; Q4VA53 CHOYP_PDS5B.1.1 m.16690 sp PDS5B_MOUSE 42.649 1442 708 20 2 1353 6 1418 0 1142 PDS5B_MOUSE reviewed Sister chromatid cohesion protein PDS5 homolog B (Androgen-induced proliferation inhibitor) (Androgen-induced prostate proliferative shutoff-associated protein AS3) Pds5b Aprin As3 Kiaa0979 Mus musculus (Mouse) 1446 cell division [GO:0051301]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of cell proliferation [GO:0008285]; regulation of cell proliferation [GO:0042127] GO:0000785; GO:0005634; GO:0005654; GO:0007064; GO:0008285; GO:0042127; GO:0051301 0 0 0 0 Q4VGL6 CHOYP_LOC558213.1.1 m.27293 sp RC3H1_MOUSE 72.549 459 118 3 11 468 1 452 0 691 RC3H1_MOUSE reviewed Roquin-1 (Roquin) (Protein Sanroque) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) Rc3h1 Gm551 Kiaa2025 Mus musculus (Mouse) 1130 "3'-UTR-mediated mRNA destabilization [GO:0061158]; B cell homeostasis [GO:0001782]; cellular response to interleukin-1 [GO:0071347]; cytoplasmic mRNA processing body assembly [GO:0033962]; lymph node development [GO:0048535]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of germinal center formation [GO:0002635]; negative regulation of T-helper cell differentiation [GO:0045623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of gene expression [GO:0010468]; regulation of germinal center formation [GO:0002634]; regulation of mRNA stability [GO:0043488]; regulation of T cell receptor signaling pathway [GO:0050856]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T follicular helper cell differentiation [GO:0061470]" GO:0000288; GO:0000932; GO:0000956; GO:0001782; GO:0002634; GO:0002635; GO:0003729; GO:0003730; GO:0005737; GO:0008270; GO:0010468; GO:0010494; GO:0010608; GO:0030889; GO:0033962; GO:0035613; GO:0042098; GO:0043029; GO:0043488; GO:0044822; GO:0045623; GO:0046007; GO:0048535; GO:0048536; GO:0050856; GO:0061014; GO:0061158; GO:0061470; GO:0071347; GO:1901224 0 0 0 PF00642;PF13445; Q503I8 CHOYP_LOC100703202.1.1 m.10370 sp NGLY1_DANRE 46.904 646 322 5 14 656 12 639 0 600 NGLY1_DANRE reviewed Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) ngly1 zgc:110561 Danio rerio (Zebrafish) (Brachydanio rerio) 644 glycoprotein catabolic process [GO:0006516] GO:0000224; GO:0005737; GO:0006516; GO:0046872 0 0 0 PF04721;PF09409;PF01841; Q52I78 CHOYP_NEMVEDRAFT_V1G135670.1.1 m.18689 sp NAMPT_PIG 59.579 475 174 5 8 464 10 484 0 574 NAMPT_PIG reviewed Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1 homolog) (PBEF) (Visfatin) NAMPT PBEF1 Sus scrofa (Pig) 491 circadian regulation of gene expression [GO:0032922]; NAD biosynthetic process [GO:0009435]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0004514; GO:0005615; GO:0005654; GO:0005737; GO:0009435; GO:0030054; GO:0032922; GO:0045944; GO:0047280; GO:0051770; GO:0070062 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1. 0 cd01569; PF04095; Q55G11 CHOYP_TRIADDRAFT_29967.1.1 m.56654 sp NCSEB_DICDI 52.855 683 304 11 33 705 43 717 0 719 NCSEB_DICDI reviewed Neutral ceramidase B (N-CDase B) (NCDase B) (EC 3.5.1.23) (Acylsphingosine deacylase 2B) (N-acylsphingosine amidohydrolase 2B) dcd2B DDB_G0268374 Dictyostelium discoideum (Slime mold) 718 ceramide metabolic process [GO:0006672] GO:0005576; GO:0006672; GO:0017040 0 0 0 PF04734;PF17048; Q561L1 CHOYP_PUA1A.1.1 m.6287 sp PUA1A_XENLA 61.124 445 166 4 3 442 11 453 0 556 PUA1A_XENLA reviewed "Adenylosuccinate synthetase isozyme 1 A (AMPSase 1 A) (AdSS 1 A) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme A) (Adenylosuccinate synthetase, muscle isozyme A) (M-type adenylosuccinate synthetase A) (IMP--aspartate ligase 1 A)" adssl1-a adss1-a Xenopus laevis (African clawed frog) 454 'de novo' AMP biosynthetic process [GO:0044208] GO:0000287; GO:0004019; GO:0005525; GO:0005737; GO:0044208 PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03126}. 0 cd03108; PF00709; Q569D5 CHOYP_SBP1.1.2 m.2083 sp SBP1_XENTR 66.808 473 153 3 9 479 2 472 0 657 SBP1_XENTR reviewed Selenium-binding protein 1 selenbp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 472 protein transport [GO:0015031] GO:0005634; GO:0005829; GO:0008430; GO:0015031; GO:0016020 0 0 0 PF05694; Q569D5 CHOYP_SBP1.2.2 m.49372 sp SBP1_XENTR 67.158 475 148 4 72 542 2 472 0 661 SBP1_XENTR reviewed Selenium-binding protein 1 selenbp1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 472 protein transport [GO:0015031] GO:0005634; GO:0005829; GO:0008430; GO:0015031; GO:0016020 0 0 0 PF05694; Q56A06 CHOYP_ISCW_ISCW017985.1.1 m.52464 sp TMTC2_MOUSE 50.948 844 395 8 4 844 3 830 0 804 TMTC2_MOUSE reviewed Transmembrane and TPR repeat-containing protein 2 Tmtc2 Mus musculus (Mouse) 836 calcium ion homeostasis [GO:0055074] GO:0005783; GO:0005789; GO:0016021; GO:0055074 0 0 0 PF08409;PF00515;PF13181; Q56A55 CHOYP_LOC101062797.1.1 m.27164 sp ABCB8_DANRE 59.543 613 248 0 66 678 97 709 0 743 ABCB8_DANRE reviewed "ATP-binding cassette sub-family B member 8, mitochondrial" abcb8 zgc:113037 Danio rerio (Zebrafish) (Brachydanio rerio) 714 transmembrane transport [GO:0055085] GO:0005524; GO:0005743; GO:0016021; GO:0042626; GO:0055085 0 0 0 PF00664;PF00005; Q58A65 CHOYP_JIP3.1.1 m.25162 sp JIP4_MOUSE 50.463 1080 402 26 466 1519 344 1316 0 981 JIP4_MOUSE reviewed C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (JNK-associated leucine-zipper protein) (JLP) (JNK/SAPK-associated protein 2) (JSAP2) (Mitogen-activated protein kinase 8-interacting protein 4) (Sperm-associated antigen 9) Spag9 Jip4 Jsap2 Kiaa0516 Mapk8ip4 Mus musculus (Mouse) 1321 "activation of JUN kinase activity [GO:0007257]; activation of MAPK activity [GO:0000187]; negative regulation of protein homodimerization activity [GO:0090074]; positive regulation of cell migration [GO:0030335]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; retrograde transport, endosome to Golgi [GO:0042147]; striated muscle cell differentiation [GO:0051146]; vesicle-mediated transport [GO:0016192]" GO:0000187; GO:0005078; GO:0005737; GO:0005815; GO:0005829; GO:0007257; GO:0008432; GO:0016192; GO:0019894; GO:0030159; GO:0030335; GO:0042147; GO:0043410; GO:0045666; GO:0048273; GO:0048471; GO:0051146; GO:0051149; GO:0051260; GO:0070062; GO:0090074 0 0 0 PF16471;PF09744; Q58A65 CHOYP_JIP4.1.4 m.2029 sp JIP4_MOUSE 49.745 1373 537 36 15 1307 17 1316 0 1192 JIP4_MOUSE reviewed C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (JNK-associated leucine-zipper protein) (JLP) (JNK/SAPK-associated protein 2) (JSAP2) (Mitogen-activated protein kinase 8-interacting protein 4) (Sperm-associated antigen 9) Spag9 Jip4 Jsap2 Kiaa0516 Mapk8ip4 Mus musculus (Mouse) 1321 "activation of JUN kinase activity [GO:0007257]; activation of MAPK activity [GO:0000187]; negative regulation of protein homodimerization activity [GO:0090074]; positive regulation of cell migration [GO:0030335]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; retrograde transport, endosome to Golgi [GO:0042147]; striated muscle cell differentiation [GO:0051146]; vesicle-mediated transport [GO:0016192]" GO:0000187; GO:0005078; GO:0005737; GO:0005815; GO:0005829; GO:0007257; GO:0008432; GO:0016192; GO:0019894; GO:0030159; GO:0030335; GO:0042147; GO:0043410; GO:0045666; GO:0048273; GO:0048471; GO:0051146; GO:0051149; GO:0051260; GO:0070062; GO:0090074 0 0 0 PF16471;PF09744; Q58EN8 CHOYP_LOC100371979.1.1 m.51845 sp VP33B_DANRE 48.229 593 276 9 1 579 33 608 0 559 VP33B_DANRE reviewed Vacuolar protein sorting-associated protein 33B vps33b Danio rerio (Zebrafish) (Brachydanio rerio) 617 intrahepatic bile duct development [GO:0035622]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904] GO:0005765; GO:0006904; GO:0015031; GO:0031902; GO:0035622 0 0 0 PF00995; Q59H18 CHOYP_LOC576866.1.1 m.1119 sp TNI3K_HUMAN 58.072 830 317 9 1 809 1 820 0 959 TNI3K_HUMAN reviewed Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) TNNI3K CARK Homo sapiens (Human) 835 bundle of His cell to Purkinje myocyte communication [GO:0086069]; protein phosphorylation [GO:0006468]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027] GO:0002027; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008022; GO:0031013; GO:0046872; GO:0055117; GO:0086069; GO:1903779 0 0 0 PF12796;PF07714; Q5BJQ6 CHOYP_LOC100367837.1.1 m.56015 sp CSTF1_RAT 62.028 424 160 1 11 433 8 431 0 580 CSTF1_RAT reviewed Cleavage stimulation factor subunit 1 (Cleavage stimulation factor 50 kDa subunit) (CSTF 50 kDa subunit) (CstF-50) Cstf1 Rattus norvegicus (Rat) 431 mRNA processing [GO:0006397] GO:0005634; GO:0006397; GO:0044822 0 0 0 PF16699;PF00400; Q5BL41 CHOYP_ARP2.1.1 m.43520 sp ARP2_XENTR 91.26 389 34 0 14 402 1 389 0 744 ARP2_XENTR reviewed Actin-related protein 2 (Actin-like protein 2) actr2 arp2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 394 Arp2/3 complex-mediated actin nucleation [GO:0034314] GO:0005524; GO:0005737; GO:0005885; GO:0034314; GO:0042995 0 0 0 PF00022; Q5E9G1 CHOYP_P2R3C.1.1 m.7759 sp P2R3C_BOVIN 76.889 450 92 3 12 452 1 447 0 717 P2R3C_BOVIN reviewed Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma PPP2R3C Bos taurus (Bovine) 453 activation of protein kinase activity [GO:0032147]; B cell homeostasis [GO:0001782]; cortical cytoskeleton organization [GO:0030865]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of B cell differentiation [GO:0045579]; regulation of antimicrobial humoral response [GO:0002759]; regulation of mitochondrial depolarization [GO:0051900]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029] GO:0000226; GO:0001782; GO:0002759; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0030865; GO:0032147; GO:0043029; GO:0045579; GO:0046872; GO:0048536; GO:0051900 0 0 0 0 Q5E9H5 CHOYP_BCS1.1.1 m.17484 sp BCS1_BOVIN 63.309 417 153 0 1 417 1 417 0 556 BCS1_BOVIN reviewed Mitochondrial chaperone BCS1 (BCS1-like protein) BCS1L Bos taurus (Bovine) 419 mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrial respiratory chain complex IV assembly [GO:0033617] GO:0005524; GO:0005743; GO:0016021; GO:0032981; GO:0033617; GO:0034551 0 0 0 PF00004;PF08740; Q5E9N0 CHOYP_BRAFLDRAFT_277920.1.1 m.28845 sp BYST_BOVIN 62.207 426 144 6 24 435 6 428 0 546 BYST_BOVIN reviewed Bystin BYSL Bos taurus (Bovine) 435 "cell proliferation [GO:0008283]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; trophectodermal cell differentiation [GO:0001829]" GO:0000462; GO:0001829; GO:0005730; GO:0005737; GO:0008283; GO:0016020; GO:0044822; GO:0045177 0 0 0 PF05291; Q5EA95 CHOYP_IFT57.1.1 m.13249 sp IFT57_BOVIN 66.165 399 130 1 8 406 26 419 0 532 IFT57_BOVIN reviewed Intraflagellar transport protein 57 homolog IFT57 Bos taurus (Bovine) 429 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cilium assembly [GO:0042384]; heart looping [GO:0001947]; intraciliary transport [GO:0042073]; left/right pattern formation [GO:0060972]; negative regulation of epithelial cell proliferation [GO:0050680]; neural tube closure [GO:0001843]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; smoothened signaling pathway [GO:0007224]; transcription, DNA-templated [GO:0006351]" GO:0001843; GO:0001947; GO:0003677; GO:0005794; GO:0005813; GO:0005929; GO:0005930; GO:0006351; GO:0006355; GO:0006915; GO:0006919; GO:0007224; GO:0030992; GO:0032391; GO:0036064; GO:0042073; GO:0042384; GO:0042981; GO:0044292; GO:0050680; GO:0060972 0 0 0 PF10498; Q5EAJ7 CHOYP_LOC100369194.1.1 m.42345 sp MVP_STRPU 48.248 856 408 7 119 964 12 842 0 806 MVP_STRPU reviewed Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) 857 0 GO:0005634; GO:0005737; GO:0030529 0 0 cd08825; PF11978;PF01505; Q5EAJ7 CHOYP_MVP.1.1 m.56230 sp MVP_STRPU 75.587 852 205 3 4 854 8 857 0 1347 MVP_STRPU reviewed Major vault protein (MVP) MVP Strongylocentrotus purpuratus (Purple sea urchin) 857 0 GO:0005634; GO:0005737; GO:0030529 0 0 cd08825; PF11978;PF01505; Q5F201 CHOYP_BRAFLDRAFT_125119.1.1 m.57550 sp CFA52_MOUSE 53.282 655 259 7 6 659 9 617 0 673 CFA52_MOUSE reviewed Cilia- and flagella-associated protein 52 (WD repeat-containing protein 16) Cfap52 Wdr16 Mus musculus (Mouse) 620 0 GO:0005737; GO:0042995 0 0 0 PF00400; Q5F361 CHOYP_BRAFLDRAFT_113518.1.1 m.43052 sp TBCK_CHICK 55.729 899 385 6 1 896 1 889 0 1012 TBCK_CHICK reviewed TBC domain-containing protein kinase-like protein TBCK RCJMB04_32m11 Gallus gallus (Chicken) 893 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0004672; GO:0005096; GO:0005524; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF00069;PF00566;PF00581; Q5F364 CHOYP_MRP1.4.10 m.27993 sp MRP1_CHICK 41.09 1560 797 22 9 1484 3 1524 0 1189 MRP1_CHICK reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 RCJMB04_32d20 Gallus gallus (Chicken) 1525 0 GO:0005524; GO:0005886; GO:0016021; GO:0042626 0 0 0 PF00664;PF00005; Q5F3K4 CHOYP_WDR48.1.2 m.11216 sp WDR48_CHICK 58.997 678 240 13 13 666 11 674 0 768 WDR48_CHICK reviewed WD repeat-containing protein 48 (USP1-associated factor 1) WDR48 UAF1 RCJMB04_14o15 Gallus gallus (Chicken) 678 double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; positive regulation of epithelial cell proliferation [GO:0050679]; protein deubiquitination [GO:0016579]; regulation of protein monoubiquitination [GO:1902525]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; spermatogenesis [GO:0007283] GO:0000724; GO:0005634; GO:0005764; GO:0005770; GO:0007283; GO:0007338; GO:0016579; GO:0035264; GO:0043588; GO:0048568; GO:0048705; GO:0048872; GO:0050679; GO:0072520; GO:1902525 0 0 0 PF11816;PF00400; Q5F3K4 CHOYP_WDR48.2.2 m.43336 sp WDR48_CHICK 58.488 701 241 17 1 678 1 674 0 754 WDR48_CHICK reviewed WD repeat-containing protein 48 (USP1-associated factor 1) WDR48 UAF1 RCJMB04_14o15 Gallus gallus (Chicken) 678 double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; positive regulation of epithelial cell proliferation [GO:0050679]; protein deubiquitination [GO:0016579]; regulation of protein monoubiquitination [GO:1902525]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; spermatogenesis [GO:0007283] GO:0000724; GO:0005634; GO:0005764; GO:0005770; GO:0007283; GO:0007338; GO:0016579; GO:0035264; GO:0043588; GO:0048568; GO:0048705; GO:0048872; GO:0050679; GO:0072520; GO:1902525 0 0 0 PF11816;PF00400; Q5F3L1 CHOYP_KS6A5.1.1 m.51330 sp KS6A5_CHICK 62.877 730 253 9 16 735 17 738 0 939 KS6A5_CHICK reviewed Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) RPS6KA5 RCJMB04_14g1 Gallus gallus (Chicken) 789 histone H3-S10 phosphorylation [GO:0043987]; histone H3-S28 phosphorylation [GO:0043988]; intracellular signal transduction [GO:0035556]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000287; GO:0005524; GO:0005634; GO:0005737; GO:0035175; GO:0035556; GO:0043987; GO:0043988; GO:0045944 0 0 0 PF00069;PF00433; Q5F3X8 CHOYP_SC31A.1.2 m.8240 sp SC31A_CHICK 41.958 1287 606 29 1 1206 1 1227 0 936 SC31A_CHICK reviewed Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A) SEC31A SEC31L1 RCJMB04_4i13 Gallus gallus (Chicken) 1227 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0012507; GO:0015031; GO:0016192; GO:0030134 0 0 0 0 Q5F3X8 CHOYP_SC31A.2.2 m.18644 sp SC31A_CHICK 41.537 1288 590 28 31 1216 1 1227 0 926 SC31A_CHICK reviewed Protein transport protein Sec31A (SEC31-like protein 1) (SEC31-related protein A) SEC31A SEC31L1 RCJMB04_4i13 Gallus gallus (Chicken) 1227 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0012507; GO:0015031; GO:0016192; GO:0030134 0 0 0 0 Q5F415 CHOYP_LOC100375955.1.1 m.9940 sp TBC23_CHICK 53.734 683 304 9 7 684 4 679 0 723 TBC23_CHICK reviewed TBC1 domain family member 23 TBC1D23 RCJMB04_3n7 Gallus gallus (Chicken) 679 0 0 0 0 0 PF00566;PF00581; Q5F428 CHOYP_EIF3L.1.1 m.7542 sp EIF3L_CHICK 70.916 557 138 3 3 538 5 558 0 826 EIF3L_CHICK reviewed Eukaryotic translation initiation factor 3 subunit L (eIF3l) EIF3L EIF3EIP EIF3S6IP RCJMB04_3l6 Gallus gallus (Chicken) 564 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001650; GO:0001731; GO:0003743; GO:0005654; GO:0005852; GO:0006413; GO:0006446; GO:0016020; GO:0016282; GO:0033290; GO:0044822 0 0 0 PF10255; Q5F452 CHOYP_ISCW_ISCW018501.2.2 m.61797 sp MTMR8_CHICK 57.621 538 215 7 42 573 8 538 0 656 MTMR8_CHICK reviewed Myotubularin-related protein 8 (EC 3.1.3.-) MTMR8 RCJMB04_3d12 Gallus gallus (Chicken) 629 phosphatidylinositol dephosphorylation [GO:0046856]; regulation of autophagy [GO:0010506] GO:0004438; GO:0004725; GO:0005635; GO:0010506; GO:0046856; GO:0052629 0 0 0 PF06602; Q5F471 CHOYP_PP6R3.1.1 m.43072 sp PP6R3_CHICK 48.564 801 361 18 1 785 1 766 0 689 PP6R3_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) PPP6R3 PP6R3 SAPS3 RCJMB04_2j4 Gallus gallus (Chicken) 873 regulation of phosphoprotein phosphatase activity [GO:0043666] GO:0005654; GO:0005737; GO:0005886; GO:0043666 0 0 0 PF04499; Q5F499 CHOYP_LOC100877393.1.1 m.26310 sp OPA1_CHICK 56.798 912 359 6 93 993 90 977 0 1033 OPA1_CHICK reviewed "Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like 120 kDa protein, form S1]" OPA1 RCJMB04_1m16 Gallus gallus (Chicken) 977 apoptotic process [GO:0006915]; mitochondrion organization [GO:0007005] GO:0003924; GO:0005525; GO:0005743; GO:0005758; GO:0006915; GO:0007005; GO:0016021 0 0 0 PF00350; Q5FWR0 CHOYP_LOC100373244.1.1 m.13761 sp SMRCD_XENTR 41.604 935 472 17 83 1004 129 1002 0 703 SMRCD_XENTR reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) smarcad1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1003 ATP-dependent chromatin remodeling [GO:0043044]; covalent chromatin modification [GO:0016569]; DNA double-strand break processing [GO:0000729] GO:0000729; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0016569; GO:0035861; GO:0043044 0 0 0 PF00271;PF00176; Q5GIS3 CHOYP_GBB.1.2 m.1845 sp GBB_PINFU 93.143 350 15 1 1 350 1 341 0 675 GBB_PINFU reviewed Guanine nucleotide-binding protein subunit beta (pfGbeta1) (G protein subunit beta-1) 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 341 0 GO:0004871; GO:0005737 0 0 0 PF00400; Q5GIS3 CHOYP_GBB.2.2 m.35275 sp GBB_PINFU 96.481 341 12 0 1 341 1 341 0 689 GBB_PINFU reviewed Guanine nucleotide-binding protein subunit beta (pfGbeta1) (G protein subunit beta-1) 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 341 0 GO:0004871; GO:0005737 0 0 0 PF00400; Q5GIS3 CHOYP_LOC100368865.1.1 m.48101 sp GBB_PINFU 97.067 341 10 0 1 341 1 341 0 693 GBB_PINFU reviewed Guanine nucleotide-binding protein subunit beta (pfGbeta1) (G protein subunit beta-1) 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 341 0 GO:0004871; GO:0005737 0 0 0 PF00400; Q5GN48 CHOYP_DLP.1.1 m.31353 sp DMD_PIG 41.268 1672 878 24 2145 3757 2033 3659 0 1219 DMD_PIG reviewed Dystrophin DMD Sus scrofa (Pig) 3674 muscle attachment [GO:0016203] GO:0005200; GO:0005737; GO:0005856; GO:0008270; GO:0016203; GO:0030054; GO:0042383; GO:0045211 0 0 0 PF00307;PF09068;PF09069;PF00435;PF00397;PF00569; Q5H7C0 CHOYP_LOC100378644.1.2 m.7716 sp CDC20_PIG 51.744 516 221 10 1 511 1 493 0 521 CDC20_PIG reviewed Cell division cycle protein 20 homolog (p55CDC) CDC20 Sus scrofa (Pig) 499 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; positive regulation of meiotic cell cycle process involved in oocyte maturation [GO:1904146]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein ubiquitination [GO:0016567]; regulation of meiotic nuclear division [GO:0040020] GO:0000922; GO:0005654; GO:0005680; GO:0005737; GO:0005815; GO:0007067; GO:0008054; GO:0016567; GO:0031145; GO:0031915; GO:0040020; GO:0051301; GO:0090129; GO:0097027; GO:1904146; GO:1904668 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12894;PF00400; Q5H8C1 CHOYP_FREM1.1.1 m.55119 sp FREM1_HUMAN 36.562 2199 1233 28 25 2114 30 2175 0 1415 FREM1_HUMAN reviewed FRAS1-related extracellular matrix protein 1 (Protein QBRICK) FREM1 C9orf143 C9orf145 C9orf154 Homo sapiens (Human) 2179 cell communication [GO:0007154]; cell-matrix adhesion [GO:0007160]; craniofacial suture morphogenesis [GO:0097094] GO:0005604; GO:0007154; GO:0007160; GO:0016021; GO:0030246; GO:0046872; GO:0097094 0 0 0 PF03160;PF00059; Q5H8C4 CHOYP_BRAFLDRAFT_226506.1.3 m.1062 sp VP13A_MOUSE 35.06 3320 1913 74 1 3236 1 3161 0 1823 VP13A_MOUSE reviewed Vacuolar protein sorting-associated protein 13A (Chorea-acanthocytosis protein homolog) (Chorein) Vps13a Chac Kiaa0986 Mus musculus (Mouse) 3166 locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; social behavior [GO:0035176] GO:0006623; GO:0007399; GO:0007626; GO:0019898; GO:0031045; GO:0035176; GO:0045053 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q5H8C4 CHOYP_BRAFLDRAFT_226506.3.3 m.53203 sp VP13A_MOUSE 35.18 3303 1925 73 1 3229 1 3161 0 1816 VP13A_MOUSE reviewed Vacuolar protein sorting-associated protein 13A (Chorea-acanthocytosis protein homolog) (Chorein) Vps13a Chac Kiaa0986 Mus musculus (Mouse) 3166 locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; social behavior [GO:0035176] GO:0006623; GO:0007399; GO:0007626; GO:0019898; GO:0031045; GO:0035176; GO:0045053 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q5I085 CHOYP_PP1B.1.3 m.21709 sp PP1B_XENTR 95.666 323 14 0 13 335 5 327 0 646 PP1B_XENTR reviewed Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) ppp1cb TEgg049h05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 327 cell cycle [GO:0007049]; cell division [GO:0051301]; glycogen metabolic process [GO:0005977]; regulation of cell adhesion [GO:0030155] GO:0004721; GO:0005634; GO:0005737; GO:0005977; GO:0007049; GO:0030155; GO:0046872; GO:0050115; GO:0051301; GO:0072357 0 0 0 PF00149;PF16891; Q5I085 CHOYP_PP1B.2.3 m.22075 sp PP1B_XENTR 95.666 323 14 0 70 392 5 327 0 650 PP1B_XENTR reviewed Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) ppp1cb TEgg049h05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 327 cell cycle [GO:0007049]; cell division [GO:0051301]; glycogen metabolic process [GO:0005977]; regulation of cell adhesion [GO:0030155] GO:0004721; GO:0005634; GO:0005737; GO:0005977; GO:0007049; GO:0030155; GO:0046872; GO:0050115; GO:0051301; GO:0072357 0 0 0 PF00149;PF16891; Q5I085 CHOYP_PP1B.3.3 m.53678 sp PP1B_XENTR 95.092 326 16 0 7 332 2 327 0 649 PP1B_XENTR reviewed Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) ppp1cb TEgg049h05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 327 cell cycle [GO:0007049]; cell division [GO:0051301]; glycogen metabolic process [GO:0005977]; regulation of cell adhesion [GO:0030155] GO:0004721; GO:0005634; GO:0005737; GO:0005977; GO:0007049; GO:0030155; GO:0046872; GO:0050115; GO:0051301; GO:0072357 0 0 0 PF00149;PF16891; Q5I598 CHOYP_MTHR.1.1 m.54596 sp MTHR_BOVIN 64 600 212 3 35 633 44 640 0 818 MTHR_BOVIN reviewed Methylenetetrahydrofolate reductase (EC 1.5.1.20) MTHFR Bos taurus (Bovine) 655 methionine metabolic process [GO:0006555]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate interconversion [GO:0035999] GO:0004489; GO:0005829; GO:0006555; GO:0006730; GO:0035999 PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. 0 cd00537; PF02219; Q5I7G2 CHOYP_RXR.1.2 m.45987 sp RXR_LYMST 81.598 413 63 3 24 428 29 436 0 695 RXR_LYMST reviewed Retinoic acid receptor RXR (Retinoid X receptor) (LymRXR) RXR Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 436 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0005737; GO:0006351; GO:0007275; GO:0008270; GO:0016020; GO:0016918; GO:0030424; GO:0030426; GO:0043565 0 0 0 PF00104;PF00105; Q5I7G2 CHOYP_RXR.2.2 m.52044 sp RXR_LYMST 78.873 426 64 4 58 475 29 436 0 685 RXR_LYMST reviewed Retinoic acid receptor RXR (Retinoid X receptor) (LymRXR) RXR Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 436 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0005737; GO:0006351; GO:0007275; GO:0008270; GO:0016020; GO:0016918; GO:0030424; GO:0030426; GO:0043565 0 0 0 PF00104;PF00105; Q5IGR7 CHOYP_EXT1A.1.1 m.53760 sp EXT1B_DANRE 54.594 751 301 12 1 723 1 739 0 825 EXT1B_DANRE reviewed Exostosin-1b (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase 1b) (Multiple exostoses protein 1 homolog b) ext1b Danio rerio (Zebrafish) (Brachydanio rerio) 741 glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486] GO:0006024; GO:0006486; GO:0015012; GO:0030176; GO:0046872; GO:0050508; GO:0050509 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03016;PF09258; Q5JS13 CHOYP_RGPS1.1.1 m.16037 sp RGPS1_HUMAN 52.557 567 228 12 111 662 17 557 0 528 RGPS1_HUMAN reviewed Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) RALGPS1 KIAA0351 RALGEF2 Homo sapiens (Human) 557 intracellular signal transduction [GO:0035556]; regulation of Ral protein signal transduction [GO:0032485]; small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005737; GO:0005886; GO:0007264; GO:0008321; GO:0032485; GO:0035556 0 0 0 PF00169;PF00617; Q5JVF3 CHOYP_PCID2.1.1 m.28679 sp PCID2_HUMAN 70.352 398 118 0 1 398 1 398 0 595 PCID2_HUMAN reviewed PCI domain-containing protein 2 (CSN12-like protein) PCID2 HT004 Homo sapiens (Human) 399 "negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of mRNA stability [GO:0043488]; spleen development [GO:0048536]" GO:0043066; GO:0043488; GO:0045579; GO:0045893; GO:0048536; GO:0090267; GO:2000117 0 0 0 PF01399; Q5JVL4 CHOYP_BRAFLDRAFT_271463.1.1 m.62869 sp EFHC1_HUMAN 54.232 638 283 5 1 636 6 636 0 713 EFHC1_HUMAN reviewed EF-hand domain-containing protein 1 (Myoclonin-1) EFHC1 Homo sapiens (Human) 640 cerebral cortex cell migration [GO:0021795] GO:0005509; GO:0005737; GO:0005813; GO:0005930; GO:0008022; GO:0021795; GO:0043025; GO:0072686 0 0 0 PF06565; Q5JWR5 CHOYP_PHUM_PHUM092120.1.1 m.33493 sp DOP1_HUMAN 41.771 1197 576 26 1119 2289 1359 2460 0 891 DOP1_HUMAN reviewed Protein dopey-1 DOPEY1 KIAA1117 Homo sapiens (Human) 2465 protein transport [GO:0015031] GO:0015031 0 0 0 PF04118; Q5M786 CHOYP_WDR5.2.3 m.6293 sp WDR5_XENTR 87.915 331 40 0 20 350 3 333 0 602 WDR5_XENTR reviewed WD repeat-containing protein 5 wdr5 TEgg065j14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 334 "histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0006351; GO:0006355; GO:0043981; GO:0043982; GO:0043984; GO:0071339 0 0 0 PF00400; Q5M7G4 CHOYP_LOC100368938.2.2 m.53945 sp KAD8_XENLA 49.372 478 242 0 1 478 1 478 0 521 KAD8_XENLA reviewed Adenylate kinase 8 (AK 8) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 8) ak8 Xenopus laevis (African clawed frog) 485 nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142] GO:0004017; GO:0004127; GO:0004550; GO:0005524; GO:0005829; GO:0006165; GO:0009142 0 0 cd01428; 0 Q5M868 CHOYP_GBA2.1.2 m.6357 sp GBA2_RAT 51.345 818 379 7 16 822 66 875 0 827 GBA2_RAT reviewed Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Glucosylceramidase 2) Gba2 Rattus norvegicus (Rat) 912 bile acid metabolic process [GO:0008206]; central nervous system neuron development [GO:0021954]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139] GO:0000139; GO:0004348; GO:0005789; GO:0006680; GO:0008206; GO:0008422; GO:0016021; GO:0016139; GO:0021954 0 0 0 PF04685;PF12215; Q5M868 CHOYP_GBA2.2.2 m.64576 sp GBA2_RAT 49.413 852 378 8 16 856 66 875 0 810 GBA2_RAT reviewed Non-lysosomal glucosylceramidase (NLGase) (EC 3.2.1.45) (Beta-glucocerebrosidase 2) (Beta-glucosidase 2) (Glucosylceramidase 2) Gba2 Rattus norvegicus (Rat) 912 bile acid metabolic process [GO:0008206]; central nervous system neuron development [GO:0021954]; glucosylceramide catabolic process [GO:0006680]; glycoside catabolic process [GO:0016139] GO:0000139; GO:0004348; GO:0005789; GO:0006680; GO:0008206; GO:0008422; GO:0016021; GO:0016139; GO:0021954 0 0 0 PF04685;PF12215; Q5NC05 CHOYP_TTF2.1.1 m.10374 sp TTF2_MOUSE 44.498 836 372 14 389 1219 390 1138 0 677 TTF2_MOUSE reviewed Transcription termination factor 2 (EC 3.6.4.-) (RNA polymerase II termination factor) (Transcription release factor 2) Ttf2 Mus musculus (Mouse) 1138 "DNA-templated transcription, termination [GO:0006353]; mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]" GO:0003677; GO:0005524; GO:0005681; GO:0005737; GO:0006353; GO:0006355; GO:0006397; GO:0008026; GO:0008270; GO:0008380 0 0 0 PF00271;PF00176;PF06839; Q5NDL2 CHOYP_EOGT.1.1 m.46530 sp EOGT_HUMAN 56.855 496 199 4 36 529 36 518 0 605 EOGT_HUMAN reviewed EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase) EOGT AER61 C3orf64 EOGT1 Homo sapiens (Human) 527 protein O-linked glycosylation [GO:0006493] GO:0005788; GO:0006493; GO:0016262 0 0 0 PF04577; Q5NDL2 CHOYP_MED24.4.10 m.16710 sp EOGT_HUMAN 57.404 493 194 5 24 514 40 518 0 602 EOGT_HUMAN reviewed EGF domain-specific O-linked N-acetylglucosamine transferase (EC 2.4.1.255) (Extracellular O-linked N-acetylglucosamine transferase) EOGT AER61 C3orf64 EOGT1 Homo sapiens (Human) 527 protein O-linked glycosylation [GO:0006493] GO:0005788; GO:0006493; GO:0016262 0 0 0 PF04577; Q5PQN1 CHOYP_HERC4.1.1 m.54239 sp HERC4_RAT 52.125 1059 490 7 7 1053 4 1057 0 1110 HERC4_RAT reviewed Probable E3 ubiquitin-protein ligase HERC4 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 4) (HECT-type E3 ubiquitin transferase HERC4) Herc4 Rattus norvegicus (Rat) 1057 cell differentiation [GO:0030154]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0007283; GO:0016874; GO:0030154; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632;PF00415; Q5PQY6 CHOYP_BRAFLDRAFT_67608.1.2 m.12709 sp LONP2_DANRE 65.517 841 266 8 7 841 5 827 0 1088 LONP2_DANRE reviewed "Lon protease homolog 2, peroxisomal (EC 3.4.21.-)" lonp2 zgc:92557 Danio rerio (Zebrafish) (Brachydanio rerio) 840 misfolded or incompletely synthesized protein catabolic process [GO:0006515]; protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein targeting to peroxisome [GO:0006625] GO:0004176; GO:0004252; GO:0005524; GO:0005782; GO:0006515; GO:0006625; GO:0016485; GO:0016558 0 0 0 PF00004;PF05362;PF02190; Q5QQ53 CHOYP_XYLT.2.2 m.48490 sp XYLT_DROPS 39.672 915 487 15 9 900 6 878 0 665 XYLT_DROPS reviewed Xylosyltransferase oxt (EC 2.4.2.26) (Peptide O-xylosyltransferase) oxt xt GA16815 Drosophila pseudoobscura pseudoobscura (Fruit fly) 880 chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; D-xylose metabolic process [GO:0042732]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] GO:0000139; GO:0005789; GO:0008375; GO:0015012; GO:0016021; GO:0030158; GO:0030206; GO:0042732; GO:0050650 PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. 0 0 PF02485;PF01822;PF12529; Q5R2J2 CHOYP_LOC578260.1.1 m.21677 sp G3P_PELSI 76.647 334 76 2 26 359 1 332 0 528 G3P_PELSI reviewed Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) GAPDH Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis) 333 glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; microtubule cytoskeleton organization [GO:0000226]; neuron apoptotic process [GO:0051402]; peptidyl-cysteine S-trans-nitrosylation [GO:0035606]; protein stabilization [GO:0050821] GO:0000226; GO:0004365; GO:0005634; GO:0005737; GO:0005829; GO:0006006; GO:0006096; GO:0008017; GO:0015630; GO:0035605; GO:0035606; GO:0050661; GO:0050821; GO:0051287; GO:0051402 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. 0 0 PF02800;PF00044; Q5R416 CHOYP_PHUM_PHUM450820.1.1 m.40803 sp CTNA2_PONAB 66.413 920 281 8 2 910 3 905 0 1212 CTNA2_PONAB reviewed Catenin alpha-2 (Alpha N-catenin) CTNNA2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 905 axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; dendrite morphogenesis [GO:0048813]; prepulse inhibition [GO:0060134]; radial glia guided migration of Purkinje cell [GO:0021942]; regulation of synapse structural plasticity [GO:0051823]; single organismal cell-cell adhesion [GO:0016337] GO:0005198; GO:0005634; GO:0005737; GO:0005912; GO:0005913; GO:0007409; GO:0015629; GO:0016323; GO:0016337; GO:0021942; GO:0030027; GO:0030424; GO:0048813; GO:0048854; GO:0051823; GO:0060134 0 0 0 PF01044; Q5R432 CHOYP_CNDP2.4.4 m.56870 sp CNDP2_PONAB 59.231 520 153 4 6 525 7 467 0 638 CNDP2_PONAB reviewed Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) CNDP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 475 0 GO:0004180; GO:0005737; GO:0008237; GO:0046872; GO:0102008 0 0 cd05676; PF07687;PF01546; Q5R440 CHOYP_CALX.1.1 m.12010 sp CALX_PONAB 54.682 598 251 5 39 625 4 592 0 637 CALX_PONAB reviewed Calnexin CANX Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 592 clathrin-mediated endocytosis [GO:0072583]; protein folding [GO:0006457]; synaptic vesicle endocytosis [GO:0048488] GO:0005509; GO:0005783; GO:0005789; GO:0006457; GO:0016021; GO:0030246; GO:0042470; GO:0045202; GO:0048488; GO:0072583 0 0 0 PF00262; Q5R478 CHOYP_AP3M2.1.1 m.43706 sp AP3M1_PONAB 70.167 419 123 2 1 418 1 418 0 653 AP3M1_PONAB reviewed AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin) AP3M1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 418 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; intracellular protein transport [GO:0006886] GO:0005765; GO:0005794; GO:0006886; GO:0008089; GO:0030131; GO:0030659; GO:0048490; GO:1904115 0 0 0 PF00928;PF01217; Q5R481 CHOYP_LOC373275.4.7 m.47547 sp SEPT7_PONAB 75.467 375 90 1 179 551 25 399 0 579 SEPT7_PONAB reviewed Septin-7 7-Sep Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 437 cell division [GO:0051301]; cilium morphogenesis [GO:0060271]; mitotic nuclear division [GO:0007067]; regulation of embryonic cell shape [GO:0016476] GO:0000777; GO:0005525; GO:0005819; GO:0005930; GO:0007067; GO:0016476; GO:0030496; GO:0031105; GO:0032154; GO:0051301; GO:0060271 0 0 cd01850; PF00735; Q5R481 CHOYP_SEPT7.1.1 m.59134 sp SEPT7_PONAB 72.439 410 109 2 82 489 25 432 0 591 SEPT7_PONAB reviewed Septin-7 7-Sep Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 437 cell division [GO:0051301]; cilium morphogenesis [GO:0060271]; mitotic nuclear division [GO:0007067]; regulation of embryonic cell shape [GO:0016476] GO:0000777; GO:0005525; GO:0005819; GO:0005930; GO:0007067; GO:0016476; GO:0030496; GO:0031105; GO:0032154; GO:0051301; GO:0060271 0 0 cd01850; PF00735; Q5R4M2 CHOYP_ULK4.2.3 m.17698 sp ULK4_PONAB 41.492 1099 588 16 1 1085 217 1274 0 833 ULK4_PONAB reviewed Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1275 0 GO:0004674; GO:0005524 0 0 0 PF00069; Q5R501 CHOYP_OST48.1.1 m.43513 sp OST48_PONAB 69.74 423 126 2 25 445 15 437 0 627 OST48_PONAB reviewed Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) (EC 2.4.99.18) DDOST Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 439 protein glycosylation [GO:0006486]; protein N-linked glycosylation via asparagine [GO:0018279] GO:0006486; GO:0008250; GO:0016021; GO:0016757; GO:0018279 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03345; Q5R514 CHOYP_LOC100367421.1.1 m.66338 sp UMPS_PONAB 54.936 466 207 2 26 490 11 474 0 538 UMPS_PONAB reviewed Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMPdecase)] UMPS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 480 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205] GO:0004588; GO:0004590; GO:0006207; GO:0044205 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. 0 cd06223; PF00215;PF00156; Q5R546 CHOYP_LOC100197511.1.1 m.22053 sp ATPA_PONAB 82.667 525 88 1 29 550 28 552 0 889 ATPA_PONAB reviewed "ATP synthase subunit alpha, mitochondrial" ATP5A1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 553 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0005524; GO:0005753; GO:0005886; GO:0015986; GO:0015991; GO:0045261; GO:0046933; GO:0046961 0 0 cd01132; PF00006;PF00306;PF02874; Q5R5H1 CHOYP_METK2.3.3 m.47543 sp METK2_PONAB 73.282 393 99 1 19 411 9 395 0 599 METK2_PONAB reviewed S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) MAT2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 395 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0006556; GO:0006730; GO:0046872; GO:0048269 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q5R5L3 CHOYP_NEMVEDRAFT_V1G163820.1.1 m.6391 sp DJC10_PONAB 43.253 793 407 20 5 777 16 785 0 653 DJC10_PONAB reviewed DnaJ homolog subfamily C member 10 (EC 1.8.4.-) DNAJC10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 793 cell redox homeostasis [GO:0045454]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein folding in endoplasmic reticulum [GO:0034975] GO:0005788; GO:0015035; GO:0016671; GO:0030433; GO:0034975; GO:0045454 0 0 cd06257; PF00226;PF00085; Q5R5P0 CHOYP_STRUM.1.1 m.42335 sp STRUM_PONAB 68.503 1162 361 4 1 1162 1 1157 0 1687 STRUM_PONAB reviewed WASH complex subunit strumpellin 0 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1159 protein transport [GO:0015031] GO:0005769; GO:0005783; GO:0005829; GO:0015031; GO:0071203 0 0 0 PF10266; Q5R5P3 CHOYP_THNS1.1.1 m.28661 sp THNS1_PONAB 45.775 710 354 11 33 726 43 737 0 639 THNS1_PONAB reviewed Threonine synthase-like 1 (TSH1) THNSL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 743 0 0 0 0 cd00464; PF00291;PF01202;PF14821; Q5R5V4 CHOYP_ISCW_ISCW017519.1.2 m.935 sp ILK_PONAB 61.006 477 158 3 1 474 1 452 0 613 ILK_PONAB reviewed Integrin-linked protein kinase (EC 2.7.11.1) ILK Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 452 0 GO:0004674; GO:0005524; GO:0005886; GO:0005925; GO:0030017; GO:0030027 0 0 0 PF12796;PF07714; Q5R5V4 CHOYP_ISCW_ISCW017519.2.2 m.15263 sp ILK_PONAB 63.677 446 159 2 1 443 1 446 0 612 ILK_PONAB reviewed Integrin-linked protein kinase (EC 2.7.11.1) ILK Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 452 0 GO:0004674; GO:0005524; GO:0005886; GO:0005925; GO:0030017; GO:0030027 0 0 0 PF12796;PF07714; Q5R629 CHOYP_ARMC9.1.1 m.57265 sp ARMC9_PONAB 54.436 665 282 9 11 662 4 660 0 669 ARMC9_PONAB reviewed LisH domain-containing protein ARMC9 ARMC9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 665 0 0 0 0 0 0 Q5R6H7 CHOYP_SMAD1.2.2 m.60397 sp SMAD5_PONAB 77.311 476 73 7 5 456 1 465 0 712 SMAD5_PONAB reviewed Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (SMAD family member 5) (SMAD 5) (Smad5) SMAD5 MADH5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 465 "BMP signaling pathway [GO:0030509]; bone development [GO:0060348]; cardiac muscle contraction [GO:0060048]; cartilage development [GO:0051216]; cellular response to organic cyclic compound [GO:0071407]; embryonic pattern specification [GO:0009880]; erythrocyte differentiation [GO:0030218]; germ cell development [GO:0007281]; osteoblast fate commitment [GO:0002051]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; protein phosphorylation [GO:0006468]; SMAD protein signal transduction [GO:0060395]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]" GO:0000979; GO:0001657; GO:0002051; GO:0003700; GO:0005654; GO:0005667; GO:0005737; GO:0006351; GO:0006468; GO:0007179; GO:0007281; GO:0009880; GO:0030218; GO:0030509; GO:0045669; GO:0046872; GO:0051216; GO:0060048; GO:0060348; GO:0060395; GO:0071407; GO:1901522 0 0 0 PF03165;PF03166; Q5R6K8 CHOYP_PP4C.1.1 m.10112 sp PP4C_PONAB 94.059 303 18 0 3 305 5 307 0 601 PP4C_PONAB reviewed Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) PPP4C Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 307 regulation of double-strand break repair via homologous recombination [GO:0010569] GO:0004722; GO:0005634; GO:0005737; GO:0005815; GO:0010569; GO:0046872 0 0 0 PF00149; Q5R6K8 CHOYP_ZNT5.1.1 m.7308 sp PP4C_PONAB 94.059 303 18 0 3 305 5 307 0 601 PP4C_PONAB reviewed Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) PPP4C Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 307 regulation of double-strand break repair via homologous recombination [GO:0010569] GO:0004722; GO:0005634; GO:0005737; GO:0005815; GO:0010569; GO:0046872 0 0 0 PF00149; Q5R6L5 CHOYP_BRAFLDRAFT_118260.1.1 m.13621 sp CAND1_PONAB 71.9 1242 330 7 1 1235 1 1230 0 1823 CAND1_PONAB reviewed Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) CAND1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1230 protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265] GO:0005634; GO:0005737; GO:0010265; GO:0016567; GO:0031461 0 0 0 PF08623; Q5R6Z6 CHOYP_LOC100367949.1.3 m.49138 sp RCD1_PONAB 86.014 286 40 0 17 302 11 296 0 512 RCD1_PONAB reviewed Cell differentiation protein RCD1 homolog (Rcd-1) (CCR4-NOT transcription complex subunit 9) RQCD1 CNOT9 RCD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 299 "cytokine-mediated signaling pathway [GO:0019221]; gene silencing by RNA [GO:0031047]; mRNA catabolic process [GO:0006402]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of ligand-dependent nuclear receptor transcription coactivator activity [GO:2000327]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000932; GO:0005634; GO:0006351; GO:0006355; GO:0006402; GO:0006417; GO:0016020; GO:0019221; GO:0030014; GO:0031047; GO:0033147; GO:2000327 0 0 0 0 Q5R6Z6 CHOYP_LOC100367949.2.3 m.55056 sp RCD1_PONAB 86.014 286 40 0 50 335 11 296 0 513 RCD1_PONAB reviewed Cell differentiation protein RCD1 homolog (Rcd-1) (CCR4-NOT transcription complex subunit 9) RQCD1 CNOT9 RCD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 299 "cytokine-mediated signaling pathway [GO:0019221]; gene silencing by RNA [GO:0031047]; mRNA catabolic process [GO:0006402]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of ligand-dependent nuclear receptor transcription coactivator activity [GO:2000327]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000932; GO:0005634; GO:0006351; GO:0006355; GO:0006402; GO:0006417; GO:0016020; GO:0019221; GO:0030014; GO:0031047; GO:0033147; GO:2000327 0 0 0 0 Q5R7A7 CHOYP_LOC100367908.2.2 m.55212 sp SGK3_PONAB 63.32 488 173 5 32 515 10 495 0 644 SGK3_PONAB reviewed Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) SGK3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 496 0 GO:0004674; GO:0005524; GO:0005769; GO:0016023; GO:0035091; GO:0055037 0 0 0 PF00069;PF00433;PF00787; Q5R7H0 CHOYP_BRAFLDRAFT_202318.1.1 m.4330 sp DHTK1_PONAB 55.336 909 374 10 25 914 23 918 0 1029 DHTK1_PONAB reviewed "Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC 1.2.4.2) (Dehydrogenase E1 and transketolase domain-containing protein 1)" DHTKD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 919 generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099] GO:0004591; GO:0005739; GO:0006091; GO:0006096; GO:0006099; GO:0030976 0 0 0 PF00676;PF16870;PF02779; Q5R7R6 CHOYP_BRAFLDRAFT_92601.1.1 m.56157 sp COG4_PONAB 53 700 313 5 11 696 59 756 0 768 COG4_PONAB reviewed Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 785 protein transport [GO:0015031] GO:0000139; GO:0015031 0 0 0 PF08318; Q5R7R9 CHOYP_SNW1.2.2 m.19563 sp SNW1_PONAB 71.709 509 129 9 4 504 35 536 0 692 SNW1_PONAB reviewed SNW domain-containing protein 1 (Nuclear protein SkiP) (Ski-interacting protein) SNW1 SKIIP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 536 "intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neurogenesis [GO:0050769]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinoic acid receptor signaling pathway [GO:0048384]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000398; GO:0003713; GO:0003714; GO:0005681; GO:0006351; GO:0016363; GO:0030511; GO:0035257; GO:0042771; GO:0042809; GO:0042974; GO:0045944; GO:0046332; GO:0048026; GO:0048384; GO:0048385; GO:0050769; GO:0051571; GO:0070562 0 0 0 PF02731; Q5R8R1 CHOYP_ARP3.1.1 m.6867 sp ARP3_PONAB 84.504 413 60 1 15 423 6 418 0 722 ARP3_PONAB reviewed Actin-related protein 3 (Actin-like protein 3) ACTR3 ARP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 418 Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; cilium morphogenesis [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; spindle localization [GO:0051653] GO:0005200; GO:0005524; GO:0005737; GO:0005885; GO:0005903; GO:0005911; GO:0005925; GO:0007163; GO:0008356; GO:0016020; GO:0016344; GO:0030027; GO:0033206; GO:0034314; GO:0051653; GO:0060271; GO:0070062 0 0 0 PF00022; Q5R9H4 CHOYP_A1CF.1.2 m.8145 sp A1CF_PONAB 58.254 527 179 10 10 502 1 520 0 595 A1CF_PONAB reviewed APOBEC1 complementation factor (APOBEC1-stimulating protein) A1CF ACF Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 587 mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; protein stabilization [GO:0050821] GO:0000166; GO:0003727; GO:0005737; GO:0005783; GO:0006397; GO:0016556; GO:0030895; GO:0050821 0 0 0 PF00076; Q5R9H4 CHOYP_A1CF.2.2 m.48987 sp A1CF_PONAB 54.869 534 173 13 10 489 1 520 0 541 A1CF_PONAB reviewed APOBEC1 complementation factor (APOBEC1-stimulating protein) A1CF ACF Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 587 mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; protein stabilization [GO:0050821] GO:0000166; GO:0003727; GO:0005737; GO:0005783; GO:0006397; GO:0016556; GO:0030895; GO:0050821 0 0 0 PF00076; Q5R9R1 CHOYP_EDRF1.2.2 m.45353 sp EDRF1_PONAB 37.424 1149 608 30 94 1154 67 1192 0 634 EDRF1_PONAB reviewed Erythroid differentiation-related factor 1 EDRF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1204 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 0 Q5RA02 CHOYP_XPOT.1.1 m.7957 sp XPOT_PONAB 51.767 962 462 2 1 961 1 961 0 1059 XPOT_PONAB reviewed Exportin-T (Exportin(tRNA)) (tRNA exportin) XPOT Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 962 intracellular protein transport [GO:0006886] GO:0000049; GO:0005634; GO:0005737; GO:0006886 0 0 0 PF03810;PF08389; Q5RA22 CHOYP_contig_002279 m.2484 sp 5NTC_PONAB 56.023 523 211 5 34 538 27 548 0 616 5NTC_PONAB reviewed Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II) NT5C2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 561 nucleotide metabolic process [GO:0009117] GO:0000166; GO:0005737; GO:0008253; GO:0009117; GO:0046872 0 0 0 PF05761; Q5RA96 CHOYP_GUAA.1.1 m.18809 sp GUAA_PONAB 66.325 683 228 1 5 685 11 693 0 970 GUAA_PONAB reviewed GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) GMPS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 693 glutamine metabolic process [GO:0006541]; GMP biosynthetic process [GO:0006177] GO:0003922; GO:0005524; GO:0005737; GO:0006177; GO:0006541; GO:0016462 PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. 0 cd01742;cd01997; PF00117;PF00958;PF02540; Q5RAY1 CHOYP_LOC100121969.1.1 m.52130 sp P3C2A_PONAB 38.712 1444 806 32 401 1794 265 1679 0 952 P3C2A_PONAB reviewed Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) PIK3C2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1685 endocytosis [GO:0006897]; exocytosis [GO:0006887]; phosphatidylinositol-mediated signaling [GO:0048015] GO:0005524; GO:0005634; GO:0005737; GO:0005794; GO:0005886; GO:0006887; GO:0006897; GO:0030136; GO:0031982; GO:0035005; GO:0035091; GO:0048015 0 0 0 PF00168;PF00454;PF00792;PF00794;PF00613;PF00787; Q5RB71 CHOYP_MTO1.1.1 m.10050 sp MTO1_PONAB 59.395 628 248 5 43 665 37 662 0 744 MTO1_PONAB reviewed "Protein MTO1 homolog, mitochondrial" MTO1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 692 tRNA wobble uridine modification [GO:0002098] GO:0002098; GO:0005739; GO:0016491; GO:0050660 0 0 0 PF01134;PF13932; Q5RBH9 CHOYP_LOC100123075.1.1 m.8128 sp NRBP_PONAB 59.348 460 177 6 65 518 60 515 0 525 NRBP_PONAB reviewed Nuclear receptor-binding protein NRBP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 535 ER to Golgi vesicle-mediated transport [GO:0006888]; protein phosphorylation [GO:0006468] GO:0005938; GO:0006468; GO:0006888; GO:0012505; GO:0016020; GO:0030027; GO:0048471 0 0 0 PF07714; Q5RBL1 CHOYP_LOC100123216.1.1 m.28671 sp SYG_PONAB 63.072 677 244 4 68 740 61 735 0 925 SYG_PONAB reviewed Glycine--tRNA ligase (EC 3.6.1.17) (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS) GARS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 739 diadenosine tetraphosphate biosynthetic process [GO:0015966]; glycyl-tRNA aminoacylation [GO:0006426] GO:0004081; GO:0004820; GO:0005524; GO:0005739; GO:0006426; GO:0015966; GO:0030424; GO:0046983 0 0 cd00774; PF03129;PF00587;PF00458; Q5RBQ4 CHOYP_BRAFLDRAFT_63924.1.1 m.14144 sp UBP46_PONAB 73.816 359 83 4 1 352 12 366 0 541 UBP46_PONAB reviewed Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) USP46 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 366 "behavior [GO:0007610]; protein deubiquitination [GO:0016579]; regulation of synaptic transmission, GABAergic [GO:0032228]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0004843; GO:0006511; GO:0007610; GO:0016579; GO:0032228 0 0 0 PF00443; Q5RC80 CHOYP_RBM39.1.1 m.19427 sp RBM39_PONAB 68.354 395 118 2 114 508 135 522 0 539 RBM39_PONAB reviewed RNA-binding protein 39 (RNA-binding motif protein 39) RBM39 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 524 "mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003723; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0016607 0 0 0 PF15519;PF00076; Q5RCN6 CHOYP_CP4V2.1.1 m.54640 sp CP4V2_PONAB 52.51 518 221 6 27 533 17 520 0 543 CP4V2_PONAB reviewed Cytochrome P450 4V2 (EC 1.14.13.-) (Docosahexaenoic acid omega-hydroxylase CYP4V2) (EC 1.14.13.199) CYP4V2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 525 fatty acid omega-oxidation [GO:0010430] GO:0004497; GO:0005506; GO:0005789; GO:0010430; GO:0016021; GO:0016705; GO:0020037 PATHWAY: Lipid metabolism. {ECO:0000305}. 0 0 PF00067; Q5RCS0 CHOYP_LOC100561934.1.1 m.2553 sp ATG9A_PONAB 47.029 791 345 15 1 771 1 737 0 703 ATG9A_PONAB reviewed Autophagy-related protein 9A (APG9-like 1) ATG9A APG9L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 839 autophagy [GO:0006914]; protein transport [GO:0015031] GO:0000421; GO:0005794; GO:0006914; GO:0015031; GO:0016021; GO:0031410; GO:0031902 0 0 0 PF04109; Q5RD78 CHOYP_HECTD2.1.1 m.47328 sp HECD2_PONAB 61.787 649 245 3 191 837 124 771 0 858 HECD2_PONAB reviewed Probable E3 ubiquitin-protein ligase HECTD2 (EC 2.3.2.26) (HECT domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECTD2) HECTD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 776 0 GO:0004842; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q5RDP4 CHOYP_LARS2.1.1 m.16579 sp SYLM_PONAB 45.683 834 409 16 24 829 38 855 0 759 SYLM_PONAB reviewed "Probable leucine--tRNA ligase, mitochondrial (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)" LARS2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 903 leucyl-tRNA aminoacylation [GO:0006429] GO:0002161; GO:0004823; GO:0005524; GO:0005759; GO:0006429 0 0 0 PF08264;PF00133; Q5RDQ2 CHOYP_LOC100158931.1.1 m.8283 sp MPP5_PONAB 45.112 716 306 16 366 1067 32 674 0 568 MPP5_PONAB reviewed MAGUK p55 subfamily member 5 MPP5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 675 bicellular tight junction assembly [GO:0070830]; establishment of epithelial cell polarity [GO:0090162] GO:0005886; GO:0005923; GO:0012505; GO:0070830; GO:0090162 0 0 0 PF00625;PF02828;PF09060;PF00595;PF07653; Q5RDY7 CHOYP_LOC100368053.1.1 m.25224 sp GBB5_PONAB 70.225 356 101 2 1 354 1 353 0 537 GBB5_PONAB reviewed Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) GNB5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 353 negative regulation of voltage-gated calcium channel activity [GO:1901386] GO:0004871; GO:0016020; GO:0031682; GO:0051087; GO:1901386 0 0 0 PF00400; Q5RE47 CHOYP_DX39B.2.3 m.18241 sp DX39B_PONAB 87.765 425 51 1 25 448 1 425 0 781 DX39B_PONAB reviewed Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) DDX39B BAT1 UAP56 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 428 "negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; RNA secondary structure unwinding [GO:0010501]; spliceosomal complex assembly [GO:0000245]; viral mRNA export from host cell nucleus [GO:0046784]" GO:0000245; GO:0000346; GO:0004004; GO:0005524; GO:0005681; GO:0005687; GO:0005688; GO:0005737; GO:0010501; GO:0016607; GO:0017070; GO:0030621; GO:0032786; GO:0044822; GO:0046784; GO:2000002 0 0 0 PF00270;PF00271; Q5RE70 CHOYP_ISCW_ISCW021591.1.1 m.13969 sp INT3_PONAB 50.587 1022 476 11 11 1017 36 1043 0 988 INT3_PONAB reviewed Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) INTS3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1043 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; mitotic cell cycle checkpoint [GO:0007093]; response to ionizing radiation [GO:0010212] GO:0005634; GO:0006281; GO:0006974; GO:0007093; GO:0010212; GO:0070876 0 0 0 PF10189; Q5REB8 CHOYP_ACSS3.1.1 m.64144 sp ACSS3_PONAB 59.213 635 258 1 35 669 52 685 0 802 ACSS3_PONAB reviewed "Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1)" ACSS3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 686 metabolic process [GO:0008152] GO:0003987; GO:0005524; GO:0005739; GO:0008152 0 0 0 PF16177;PF00501;PF13193; Q5REG1 CHOYP_CBPC1.1.1 m.30713 sp SART3_PONAB 43.362 934 462 13 20 932 94 981 0 734 SART3_PONAB reviewed Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) SART3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 981 "mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; positive regulation of histone deubiquitination [GO:1903586]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000166; GO:0000244; GO:0000387; GO:0000398; GO:0005634; GO:0005654; GO:0005737; GO:0006334; GO:0015030; GO:0016607; GO:0017070; GO:0030624; GO:0042393; GO:1903586 0 0 0 PF05391;PF00076; Q5RF36 CHOYP_BRAFLDRAFT_118961.1.1 m.8363 sp NARFL_PONAB 60.248 483 184 4 10 491 1 476 0 603 NARFL_PONAB reviewed Cytosolic Fe-S cluster assembly factor NARFL (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) NARFL Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 476 iron-sulfur cluster assembly [GO:0016226] GO:0016226; GO:0046872; GO:0051539; GO:0097361 0 0 0 PF02906;PF02256; Q5RFA0 CHOYP_NELFD.1.1 m.60618 sp NELFD_PONAB 64.425 565 199 2 12 575 21 584 0 785 NELFD_PONAB reviewed Negative elongation factor D (NELF-D) (TH1-like protein) NELFCD NELFD TH1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 590 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0045892 0 0 0 PF04858; Q5RFL3 CHOYP_M3K7.3.4 m.18722 sp M3K7_PONAB 51.163 645 243 12 11 653 29 603 0 610 M3K7_PONAB reviewed Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) MAP3K7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 606 "apoptotic process [GO:0006915]; I-kappaB phosphorylation [GO:0007252]; positive regulation of JUN kinase activity [GO:0043507]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000287; GO:0004709; GO:0005524; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0006915; GO:0007252; GO:0043507 0 0 0 PF07714; Q5RFQ3 CHOYP_PWP2.1.1 m.7530 sp PWP2_PONAB 58.797 881 351 5 1 875 1 875 0 1108 PWP2_PONAB reviewed Periodic tryptophan protein 2 homolog PWP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 918 0 GO:0005730 0 0 0 PF04003;PF00400; Q5RG45 CHOYP_LOC576511.1.1 m.53180 sp CP135_DANRE 42.857 1260 611 13 8 1263 4 1158 0 868 CP135_DANRE reviewed Centrosomal protein of 135 kDa (Cep135) cep135 si:dkeyp-117h8.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1164 centriole-centriole cohesion [GO:0010457]; centriole replication [GO:0007099] GO:0005814; GO:0007099; GO:0010457 0 0 0 0 Q5RGJ5 CHOYP_C19L1.1.1 m.13954 sp C19L1_DANRE 52.574 544 230 7 1 517 1 543 0 572 C19L1_DANRE reviewed CWF19-like protein 1 cwf19l1 si:ch211-234f20.6 zgc:153338 Danio rerio (Zebrafish) (Brachydanio rerio) 544 0 GO:0003824 0 0 0 PF04677;PF04676; Q5RGU1 CHOYP_LOC100693708.1.1 m.7688 sp ADCK3_DANRE 60.31 451 178 1 201 651 165 614 0 589 ADCK3_DANRE reviewed "Atypical kinase ADCK3, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (aarF domain-containing protein kinase 3)" adck3 cabc1 zgc:92578 Danio rerio (Zebrafish) (Brachydanio rerio) 619 phosphorylation [GO:0016310]; ubiquinone biosynthetic process [GO:0006744] GO:0005524; GO:0005739; GO:0006744; GO:0016021; GO:0016301; GO:0016310; GO:0043531 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000250|UniProtKB:Q8NI60}. 0 0 PF03109; Q5RHH4 CHOYP_LOC100376289.1.1 m.60023 sp IF172_DANRE 68.016 1754 550 3 86 1837 1 1745 0 2605 IF172_DANRE reviewed Intraflagellar transport protein 172 homolog ift172 si:dkey-221h15.5 Danio rerio (Zebrafish) (Brachydanio rerio) 1745 cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; photoreceptor cell maintenance [GO:0045494]; pronephros development [GO:0048793]; regulation of TOR signaling [GO:0032006]; retina development in camera-type eye [GO:0060041] GO:0005929; GO:0005930; GO:0030992; GO:0032006; GO:0036064; GO:0042384; GO:0045494; GO:0048793; GO:0060041; GO:0060271 0 0 0 0 Q5RHR6 CHOYP_BROMI.1.2 m.11676 sp BROMI_DANRE 41.474 1343 698 26 10 1324 11 1293 0 1025 BROMI_DANRE reviewed Protein broad-minded (TBC1 domain family member 32) tbc1d32 bromi si:dkey-233p4.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1298 axoneme assembly [GO:0035082]; cilium morphogenesis [GO:0060271]; multicellular organism development [GO:0007275] GO:0005737; GO:0005929; GO:0007275; GO:0035082; GO:0060271 0 0 0 PF14961; Q5RHR6 CHOYP_BROMI.2.2 m.60913 sp BROMI_DANRE 42.185 1318 698 25 10 1298 11 1293 0 1034 BROMI_DANRE reviewed Protein broad-minded (TBC1 domain family member 32) tbc1d32 bromi si:dkey-233p4.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1298 axoneme assembly [GO:0035082]; cilium morphogenesis [GO:0060271]; multicellular organism development [GO:0007275] GO:0005737; GO:0005929; GO:0007275; GO:0035082; GO:0060271 0 0 0 PF14961; Q5RIC0 CHOYP_LOC100373199.1.1 m.23667 sp ELP3_DANRE 84.545 550 82 1 1 550 1 547 0 998 ELP3_DANRE reviewed Elongator complex protein 3 (EC 2.3.1.48) elp3 si:ch211-63o20.8 zgc:113140 Danio rerio (Zebrafish) (Brachydanio rerio) 548 axonogenesis [GO:0007409]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]; tRNA wobble uridine modification [GO:0002098] GO:0000123; GO:0002098; GO:0004402; GO:0005737; GO:0006357; GO:0006368; GO:0007409; GO:0008023; GO:0008607; GO:0033588; GO:0046872; GO:0051536 0 0 0 PF00583;PF04055;PF16199; Q5RJZ1 CHOYP_RTEL1.1.1 m.16665 sp RTEL1_RAT 45.829 1043 500 18 1 1026 1 995 0 915 RTEL1_RAT reviewed Regulator of telomere elongation helicase 1 (EC 3.6.4.12) Rtel1 Rattus norvegicus (Rat) 1274 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; mitotic telomere maintenance via semi-conservative replication [GO:1902990]; negative regulation of t-circle formation [GO:1904430]; negative regulation of telomere maintenance in response to DNA damage [GO:1904506]; positive regulation of telomeric loop disassembly [GO:1904535]; regulation of double-strand break repair via homologous recombination [GO:0010569]; replication fork processing [GO:0031297]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]; telomeric loop disassembly [GO:0090657] GO:0000723; GO:0003677; GO:0004003; GO:0005524; GO:0005634; GO:0006281; GO:0006310; GO:0010569; GO:0031297; GO:0043247; GO:0046872; GO:0051539; GO:0090657; GO:1902990; GO:1904430; GO:1904506; GO:1904535 0 0 0 PF06733;PF13307; Q5RKI1 CHOYP_EF1A.3.4 m.63413 sp IF4A2_RAT 84.161 322 50 1 1 321 38 359 0 570 IF4A2_RAT reviewed Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) Eif4a2 Rattus norvegicus (Rat) 407 negative regulation of RNA-directed RNA polymerase activity [GO:1900260]; regulation of gene expression [GO:0010468]; regulation of translational initiation [GO:0006446]; RNA secondary structure unwinding [GO:0010501]; translational initiation [GO:0006413] GO:0003743; GO:0004004; GO:0005524; GO:0006413; GO:0006446; GO:0010468; GO:0010501; GO:0044822; GO:0048471; GO:1900260 0 0 0 PF00270;PF00271; Q5RKI1 CHOYP_IF4A2.1.1 m.62721 sp IF4A2_RAT 83.481 339 55 1 37 374 22 360 0 600 IF4A2_RAT reviewed Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) Eif4a2 Rattus norvegicus (Rat) 407 negative regulation of RNA-directed RNA polymerase activity [GO:1900260]; regulation of gene expression [GO:0010468]; regulation of translational initiation [GO:0006446]; RNA secondary structure unwinding [GO:0010501]; translational initiation [GO:0006413] GO:0003743; GO:0004004; GO:0005524; GO:0006413; GO:0006446; GO:0010468; GO:0010501; GO:0044822; GO:0048471; GO:1900260 0 0 0 PF00270;PF00271; Q5RKI1 CHOYP_LOC100369745.1.1 m.18815 sp IF4A2_RAT 79.661 413 72 3 18 425 2 407 0 636 IF4A2_RAT reviewed Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) Eif4a2 Rattus norvegicus (Rat) 407 negative regulation of RNA-directed RNA polymerase activity [GO:1900260]; regulation of gene expression [GO:0010468]; regulation of translational initiation [GO:0006446]; RNA secondary structure unwinding [GO:0010501]; translational initiation [GO:0006413] GO:0003743; GO:0004004; GO:0005524; GO:0006413; GO:0006446; GO:0010468; GO:0010501; GO:0044822; GO:0048471; GO:1900260 0 0 0 PF00270;PF00271; Q5SP90 CHOYP_P4R3A.1.1 m.1043 sp PP4R3_DANRE 62.33 807 279 9 67 867 2 789 0 997 PP4R3_DANRE reviewed Serine/threonine-protein phosphatase 4 regulatory subunit 3 (SMEK homolog 1) smek1 si:dkey-65b13.2 Danio rerio (Zebrafish) (Brachydanio rerio) 818 0 0 0 0 0 PF04802; Q5SPC5 CHOYP_OTOF.1.1 m.55525 sp OTOF_DANRE 51.159 1380 598 19 1 1354 1 1330 0 1410 OTOF_DANRE reviewed Otoferlin (Fer-1-like protein 2) otof fer1l2 si:dkey-181f18.3 Danio rerio (Zebrafish) (Brachydanio rerio) 1992 neuromuscular process controlling balance [GO:0050885]; response to auditory stimulus [GO:0010996]; synaptic vesicle exocytosis [GO:0016079] GO:0005509; GO:0005789; GO:0010996; GO:0016021; GO:0016079; GO:0016323; GO:0030054; GO:0030672; GO:0050885 0 0 0 PF00168;PF08150;PF08151;PF16165; Q5SPP5 CHOYP_EFR3B.1.1 m.50325 sp EFR3B_DANRE 46.391 845 387 16 1 808 1 816 0 725 EFR3B_DANRE reviewed Protein EFR3 homolog B efr3b si:ch211-203k16.1 si:ch211-215m21.18 Danio rerio (Zebrafish) (Brachydanio rerio) 816 establishment of protein localization to plasma membrane [GO:0090002]; phosphatidylinositol phosphorylation [GO:0046854] GO:0005886; GO:0046854; GO:0090002 0 0 0 0 Q5SRE5 CHOYP_NU188.2.2 m.51343 sp NU188_HUMAN 32.28 1741 1070 35 4 1691 60 1744 0 847 NU188_HUMAN reviewed Nucleoporin NUP188 homolog (hNup188) NUP188 KIAA0169 Homo sapiens (Human) 1749 gene silencing by RNA [GO:0031047]; glomerular visceral epithelial cell migration [GO:0090521]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; protein import into nucleus [GO:0006606]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; RNA export from nucleus [GO:0006405]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005635; GO:0006405; GO:0006406; GO:0006409; GO:0006606; GO:0007077; GO:0010827; GO:0016020; GO:0016032; GO:0016925; GO:0017056; GO:0019083; GO:0031047; GO:0044611; GO:0075733; GO:0090521; GO:1900034 0 0 0 PF10487; Q5SSH7 CHOYP_BRAFLDRAFT_88583.1.1 m.56300 sp ZZEF1_MOUSE 35.653 1408 792 34 86 1416 70 1440 0 810 ZZEF1_MOUSE reviewed Zinc finger ZZ-type and EF-hand domain-containing protein 1 Zzef1 Kiaa0399 Mus musculus (Mouse) 2924 0 GO:0005509; GO:0008270 0 0 0 PF03256;PF00569; Q5SWW4 CHOYP_PHUM_PHUM174820.1.1 m.57391 sp MED13_MOUSE 34.019 1555 777 60 9 1403 8 1473 0 671 MED13_MOUSE reviewed Mediator of RNA polymerase II transcription subunit 13 (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) Med13 Kiaa0593 Thrap1 Trap240 Mus musculus (Mouse) 2171 "androgen receptor signaling pathway [GO:0030521]; cholesterol homeostasis [GO:0042632]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of thyroid hormone receptor activity [GO:1904168]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription initiation from RNA polymerase II promoter [GO:0006367]; triglyceride homeostasis [GO:0070328]" GO:0001104; GO:0003712; GO:0003713; GO:0004872; GO:0005634; GO:0005654; GO:0006367; GO:0016020; GO:0016592; GO:0030518; GO:0030521; GO:0042632; GO:0045893; GO:0045944; GO:0046966; GO:0070328; GO:1904168 0 0 0 PF06333;PF11597; Q5T0N1 CHOYP_LOC100368394.1.2 m.22888 sp CFA70_HUMAN 44.063 1137 578 11 15 1119 11 1121 0 896 CFA70_HUMAN reviewed Cilia- and flagella-associated protein 70 (Tetratricopeptide repeat protein 18) (TPR repeat protein 18) CFAP70 TTC18 Homo sapiens (Human) 1121 0 GO:0005929; GO:0070062 0 0 0 PF13181; Q5T1M5 CHOYP_LOC100374077.1.1 m.5922 sp FKB15_HUMAN 37.464 1033 491 22 1 982 1 929 0 610 FKB15_HUMAN reviewed FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP and FKBP-like) (WAFL) FKBP15 KIAA0674 Homo sapiens (Human) 1219 endocytosis [GO:0006897]; negative regulation of phosphatase activity [GO:0010923]; protein folding [GO:0006457] GO:0005769; GO:0005884; GO:0006457; GO:0006897; GO:0010923; GO:0016020; GO:0030424; GO:0030426 0 0 0 PF00254; Q5T3F8 CHOYP_contig_051762 m.61949 sp CSCL2_HUMAN 41.438 765 414 13 39 792 38 779 0 583 CSCL2_HUMAN reviewed CSC1-like protein 2 (Transmembrane protein 63B) TMEM63B C6orf110 Homo sapiens (Human) 832 ion transport [GO:0006811] GO:0000166; GO:0005886; GO:0006811; GO:0015629; GO:0016021 0 0 0 PF14703;PF02714;PF13967; Q5T4S7 CHOYP_UBR4.1.1 m.34997 sp UBR4_HUMAN 50.977 5271 2383 75 15 5197 26 5183 0 5125 UBR4_HUMAN reviewed E3 ubiquitin-protein ligase UBR4 (EC 6.3.2.-) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1) UBR4 KIAA0462 KIAA1307 RBAF600 ZUBR1 Homo sapiens (Human) 5183 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; viral process [GO:0016032] GO:0004842; GO:0005654; GO:0005737; GO:0005813; GO:0008270; GO:0016020; GO:0016021; GO:0016032; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13764;PF02207; Q5T5C0 CHOYP_STXB5.1.2 m.50466 sp STXB5_HUMAN 52.841 1179 470 19 21 1170 30 1151 0 1172 STXB5_HUMAN reviewed Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) STXBP5 LLGL3 Homo sapiens (Human) 1151 exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of blood coagulation [GO:0030193]; regulation of exocytosis [GO:0017157]; regulation of gene expression [GO:0010468]; regulation of protein secretion [GO:0050708] GO:0005096; GO:0005737; GO:0005886; GO:0005892; GO:0006887; GO:0008021; GO:0010468; GO:0015031; GO:0017075; GO:0017137; GO:0017157; GO:0019905; GO:0030054; GO:0030141; GO:0030193; GO:0030659; GO:0031201; GO:0045921; GO:0050708 0 0 0 PF08596;PF08366;PF00400; Q5TAX3 CHOYP_TUT4.2.2 m.35505 sp TUT4_HUMAN 37.363 1282 643 29 248 1426 284 1508 0 737 TUT4_HUMAN reviewed Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) ZCCHC11 KIAA0191 TUT4 Homo sapiens (Human) 1644 miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; pre-miRNA processing [GO:0031054]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827] GO:0005615; GO:0005730; GO:0005737; GO:0008270; GO:0010586; GO:0010587; GO:0019827; GO:0031054; GO:0031123; GO:0044822; GO:0050265; GO:0070062 0 0 0 PF01909;PF03828;PF00098; Q5TCS8 CHOYP_AKD1.1.3 m.33440 sp KAD9_HUMAN 42.266 1959 1030 18 29 1950 14 1908 0 1407 KAD9_HUMAN reviewed Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) 1911 AMP phosphorylation [GO:0006756]; ATP generation from ADP [GO:0006757]; CDP phosphorylation [GO:0061508]; CMP phosphorylation [GO:0061566]; dADP phosphorylation [GO:0006174]; dAMP phosphorylation [GO:0061565]; dCDP phosphorylation [GO:0061570]; dCMP phosphorylation [GO:0061567]; dGDP phosphorylation [GO:0006186]; GDP phosphorylation [GO:0061568]; nucleobase-containing small molecule interconversion [GO:0015949]; TDP phosphorylation [GO:0061571]; UDP phosphorylation [GO:0061569] GO:0004550; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006174; GO:0006186; GO:0006756; GO:0006757; GO:0015949; GO:0019206; GO:0031965; GO:0050145; GO:0061508; GO:0061565; GO:0061566; GO:0061567; GO:0061568; GO:0061569; GO:0061570; GO:0061571 0 0 cd01428; 0 Q5TCS8 CHOYP_AKD1.2.3 m.49697 sp KAD9_HUMAN 43.05 1928 979 18 58 1899 14 1908 0 1380 KAD9_HUMAN reviewed Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) 1911 AMP phosphorylation [GO:0006756]; ATP generation from ADP [GO:0006757]; CDP phosphorylation [GO:0061508]; CMP phosphorylation [GO:0061566]; dADP phosphorylation [GO:0006174]; dAMP phosphorylation [GO:0061565]; dCDP phosphorylation [GO:0061570]; dCMP phosphorylation [GO:0061567]; dGDP phosphorylation [GO:0006186]; GDP phosphorylation [GO:0061568]; nucleobase-containing small molecule interconversion [GO:0015949]; TDP phosphorylation [GO:0061571]; UDP phosphorylation [GO:0061569] GO:0004550; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006174; GO:0006186; GO:0006756; GO:0006757; GO:0015949; GO:0019206; GO:0031965; GO:0050145; GO:0061508; GO:0061565; GO:0061566; GO:0061567; GO:0061568; GO:0061569; GO:0061570; GO:0061571 0 0 cd01428; 0 Q5TCS8 CHOYP_AKD1.3.3 m.63103 sp KAD9_HUMAN 43.235 1929 1011 20 55 1933 14 1908 0 1397 KAD9_HUMAN reviewed Adenylate kinase 9 (AK 9) (EC 2.7.4.4) (EC 2.7.4.6) (Adenylate kinase domain-containing protein 1) (Adenylate kinase domain-containing protein 2) AK9 AKD1 AKD2 C6orf199 C6orf224 Homo sapiens (Human) 1911 AMP phosphorylation [GO:0006756]; ATP generation from ADP [GO:0006757]; CDP phosphorylation [GO:0061508]; CMP phosphorylation [GO:0061566]; dADP phosphorylation [GO:0006174]; dAMP phosphorylation [GO:0061565]; dCDP phosphorylation [GO:0061570]; dCMP phosphorylation [GO:0061567]; dGDP phosphorylation [GO:0006186]; GDP phosphorylation [GO:0061568]; nucleobase-containing small molecule interconversion [GO:0015949]; TDP phosphorylation [GO:0061571]; UDP phosphorylation [GO:0061569] GO:0004550; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006174; GO:0006186; GO:0006756; GO:0006757; GO:0015949; GO:0019206; GO:0031965; GO:0050145; GO:0061508; GO:0061565; GO:0061566; GO:0061567; GO:0061568; GO:0061569; GO:0061570; GO:0061571 0 0 cd01428; 0 Q5TEA3 CHOYP_CT194.1.1 m.47981 sp CT194_HUMAN 35.434 1174 700 18 24 1166 27 1173 0 708 CT194_HUMAN reviewed Uncharacterized protein C20orf194 C20orf194 Homo sapiens (Human) 1177 0 0 0 0 0 0 Q5THJ4 CHOYP_VP13D.1.3 m.53042 sp VP13D_HUMAN 42.44 2295 1121 50 2300 4449 2143 4382 0 1702 VP13D_HUMAN reviewed Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) 4388 protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0006623; GO:0019898; GO:0045053; GO:0070062 0 0 0 PF12624;PF06650;PF00627;PF16908;PF16909;PF16910; Q5THJ4 CHOYP_VP13D.2.3 m.58592 sp VP13D_HUMAN 40.095 1055 508 23 1 955 2397 3427 0 746 VP13D_HUMAN reviewed Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) 4388 protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0006623; GO:0019898; GO:0045053; GO:0070062 0 0 0 PF12624;PF06650;PF00627;PF16908;PF16909;PF16910; Q5THR3 CHOYP_LOC757096.1.1 m.9762 sp EFCB6_HUMAN 30.026 1522 988 21 29 1525 32 1501 0 682 EFCB6_HUMAN reviewed EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) 1501 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q5TKA1 CHOYP_LIN9.1.1 m.12005 sp LIN9_HUMAN 56.531 490 198 6 37 517 54 537 0 555 LIN9_HUMAN reviewed Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) LIN9 BARA TGS Homo sapiens (Human) 542 "cell cycle [GO:0007049]; DNA biosynthetic process [GO:0071897]; regulation of cell cycle [GO:0051726]; transcription, DNA-templated [GO:0006351]" GO:0005654; GO:0006351; GO:0007049; GO:0017053; GO:0051726; GO:0071897 0 0 0 PF06584; Q5TZA2 CHOYP_contig_043818 m.50622 sp CROCC_HUMAN 44.01 2020 1051 21 76 2069 38 2003 0 1341 CROCC_HUMAN reviewed Rootletin (Ciliary rootlet coiled-coil protein) CROCC KIAA0445 Homo sapiens (Human) 2017 cell cycle [GO:0007049]; centriole-centriole cohesion [GO:0010457]; centrosome organization [GO:0051297]; ciliary basal body organization [GO:0032053]; epithelial structure maintenance [GO:0010669]; establishment of organelle localization [GO:0051656]; photoreceptor cell maintenance [GO:0045494]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365] GO:0001917; GO:0005198; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0007049; GO:0008104; GO:0010457; GO:0010669; GO:0015629; GO:0019894; GO:0032053; GO:0033365; GO:0035253; GO:0045494; GO:0051297; GO:0051656; GO:0070062 0 0 0 0 Q5U247 CHOYP_LOC100699161.1.1 m.35139 sp EXOC8_XENLA 44.838 678 357 10 8 681 11 675 0 588 EXOC8_XENLA reviewed Exocyst complex component 8 exoc8 Xenopus laevis (African clawed frog) 685 exocytosis [GO:0006887]; protein transport [GO:0015031] GO:0005737; GO:0006887; GO:0015031 0 0 0 PF16528; Q5U252 CHOYP_UBP47.2.2 m.66755 sp UBP47_XENLA 53.893 822 369 6 1 821 1 813 0 881 UBP47_XENLA reviewed Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) usp47 Xenopus laevis (African clawed frog) 1350 base-excision repair [GO:0006284]; cellular response to DNA damage stimulus [GO:0006974]; monoubiquitinated protein deubiquitination [GO:0035520]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005737; GO:0006284; GO:0006511; GO:0006974; GO:0035520 0 0 0 PF14560;PF00443; Q5U2P1 CHOYP_LOC100880727.1.1 m.56042 sp CNNM2_RAT 51.505 598 230 8 50 589 236 831 0 590 CNNM2_RAT reviewed Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2) Cnnm2 Acdp2 Rattus norvegicus (Rat) 875 magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693] GO:0010960; GO:0015693; GO:0016021; GO:0016323 0 0 0 PF00571;PF01595; Q5U2V4 CHOYP_LOC589177.1.1 m.52878 sp PLBL1_RAT 51.807 498 223 6 40 530 60 547 0 533 PLBL1_RAT reviewed Phospholipase B-like 1 (EC 3.1.1.-) (LAMA-like protein 1) (Lamina ancestor homolog 1) (Phospholipase B domain-containing protein 1) [Cleaved into: Phospholipase B-like 1 chain A; Phospholipase B-like 1 chain B; Phospholipase B-like 1 chain C] Plbd1 Rattus norvegicus (Rat) 550 lipid catabolic process [GO:0016042] GO:0005615; GO:0005764; GO:0016042; GO:0016787 0 0 0 PF04916; Q5U300 CHOYP_UBA1.2.2 m.30036 sp UBA1_RAT 65.094 1060 349 5 7 1049 2 1057 0 1469 UBA1_RAT reviewed Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) Uba1 Ube1 Rattus norvegicus (Rat) 1058 cellular response to DNA damage stimulus [GO:0006974]; modification-dependent protein catabolic process [GO:0019941] GO:0000792; GO:0004839; GO:0004842; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005765; GO:0005829; GO:0006974; GO:0010008; GO:0019941; GO:0030057; GO:0030867; GO:0044822; GO:0070062 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P22314}. 0 0 PF16191;PF16190;PF09358;PF00899;PF10585; Q5U367 CHOYP_PLOD3.1.1 m.41788 sp PLOD3_RAT 50.731 684 327 7 29 707 40 718 0 740 PLOD3_RAT reviewed "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3)" Plod3 Rattus norvegicus (Rat) 741 basement membrane assembly [GO:0070831]; cellular response to hormone stimulus [GO:0032870]; collagen fibril organization [GO:0030199]; endothelial cell morphogenesis [GO:0001886]; epidermis morphogenesis [GO:0048730]; in utero embryonic development [GO:0001701]; lung morphogenesis [GO:0060425]; neural tube development [GO:0021915]; protein localization [GO:0008104]; vasodilation [GO:0042311] GO:0001701; GO:0001886; GO:0005506; GO:0008104; GO:0008475; GO:0021915; GO:0030199; GO:0030867; GO:0031418; GO:0032870; GO:0033823; GO:0042311; GO:0048730; GO:0060425; GO:0070062; GO:0070831 0 0 0 0 Q5U374 CHOYP_KLH12.1.3 m.6894 sp KLH12_DANRE 61.17 564 217 2 1 563 1 563 0 734 KLH12_DANRE reviewed Kelch-like protein 12 klhl12 si:dkeyp-53e12.5 zgc:92570 Danio rerio (Zebrafish) (Brachydanio rerio) 564 anterior/posterior pattern specification [GO:0009952]; convergent extension involved in axis elongation [GO:0060028]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; protein monoubiquitination [GO:0006513]; Wnt signaling pathway [GO:0016055] GO:0000139; GO:0006513; GO:0006888; GO:0009952; GO:0016055; GO:0030134; GO:0031463; GO:0048208; GO:0060028 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q5U430 CHOYP_UBR3.1.1 m.43346 sp UBR3_MOUSE 41.544 1839 948 35 64 1813 89 1889 0 1380 UBR3_MOUSE reviewed E3 ubiquitin-protein ligase UBR3 (EC 6.3.2.-) (N-recognin-3) (Ubiquitin-protein ligase E3-alpha-3) (Ubiquitin-protein ligase E3-alpha-III) (Zinc finger protein 650) Ubr3 Kiaa2024 Zfp650 Znf650 Mus musculus (Mouse) 1889 embryo development [GO:0009790]; in utero embryonic development [GO:0001701]; olfactory behavior [GO:0042048]; sensory perception of smell [GO:0007608]; suckling behavior [GO:0001967]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] GO:0000151; GO:0001701; GO:0001967; GO:0004842; GO:0005737; GO:0006511; GO:0007608; GO:0008270; GO:0009790; GO:0016021; GO:0016874; GO:0042048; GO:0061630; GO:0071596 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02207; Q5U5D4 CHOYP_BRAFLDRAFT_212359.1.1 m.21087 sp MIOA_XENLA 39.071 883 499 22 6 867 8 872 0 627 MIOA_XENLA reviewed WD repeat-containing protein mio-A 0 Xenopus laevis (African clawed frog) 880 0 0 0 0 0 PF17034; Q5UIP0 CHOYP_RIF1.1.1 m.13682 sp RIF1_HUMAN 35.413 1138 665 31 7 1100 9 1120 0 622 RIF1_HUMAN reviewed Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) RIF1 Homo sapiens (Human) 2472 cell cycle [GO:0007049]; double-strand break repair via nonhomologous end joining [GO:0006303]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; stem cell population maintenance [GO:0019827] GO:0000781; GO:0001939; GO:0001940; GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0005886; GO:0006303; GO:0007049; GO:0019827; GO:2001034 0 0 0 PF12231; Q5VU97 CHOYP_CAHD1.4.6 m.43905 sp CAHD1_HUMAN 42.773 1190 640 18 87 1254 41 1211 0 968 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q5VW36 CHOYP_FOCAD.2.2 m.52366 sp FOCAD_HUMAN 32.904 1398 864 24 56 1407 427 1796 0 731 FOCAD_HUMAN reviewed Focadhesin FOCAD KIAA1797 Homo sapiens (Human) 1801 0 GO:0005925; GO:0016021 0 0 0 PF12530;PF11229; Q5VZK9 CHOYP_LR16A.3.3 m.59538 sp CARL1_HUMAN 37.909 1253 661 24 4 1214 5 1182 0 788 CARL1_HUMAN reviewed "F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)" LRRC16A CARMIL CARMIL1 LRRC16 Homo sapiens (Human) 1371 actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; barbed-end actin filament uncapping [GO:0051638]; blood coagulation [GO:0007596]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415] GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007015; GO:0007596; GO:0016477; GO:0030027; GO:0030032; GO:0030335; GO:0030838; GO:0031252; GO:0031529; GO:0031941; GO:0032403; GO:0044351; GO:0044354; GO:0046415; GO:0051496; GO:0051638; GO:0051639; GO:0070062; GO:1900026; GO:1902745; GO:2000813 0 0 0 PF16000;PF13516; Q5W8I8 CHOYP_VGLU2.2.3 m.52091 sp VGL2A_DANRE 55.161 591 216 10 17 598 28 578 0 608 VGL2A_DANRE reviewed Vesicular glutamate transporter 2.1 (Protein blumenkohl) (Solute carrier family 17 member 6-B) (Vesicular glutamate transporter 2-A) slc17a6b blu slc17a6 vglut2.1 vglut2a Danio rerio (Zebrafish) (Brachydanio rerio) 584 chemical synaptic transmission [GO:0007268]; L-glutamate transmembrane transport [GO:0089711]; neurotransmitter transport [GO:0006836]; response to stimulus [GO:0050896]; sodium ion transport [GO:0006814]; visual perception [GO:0007601] GO:0005313; GO:0006814; GO:0006836; GO:0007268; GO:0007601; GO:0015293; GO:0016021; GO:0030054; GO:0030672; GO:0043005; GO:0050896; GO:0089711 0 0 cd06174; PF07690; Q5XGM3 CHOYP_BHMT1.1.1 m.22614 sp BHMT1_XENLA 67.43 393 126 1 15 407 4 394 0 565 BHMT1_XENLA reviewed Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) bhmt Xenopus laevis (African clawed frog) 403 amino-acid betaine catabolic process [GO:0006579]; methionine biosynthetic process [GO:0009086] GO:0005737; GO:0006579; GO:0008270; GO:0009086; GO:0047150 PATHWAY: Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.; PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. 0 0 PF02574; Q5XGY1 CHOYP_BRAFLDRAFT_203247.1.1 m.23632 sp TSR1_XENLA 53.258 798 350 6 13 788 1 797 0 820 TSR1_XENLA reviewed Pre-rRNA-processing protein TSR1 homolog tsr1 Xenopus laevis (African clawed frog) 815 ribosome assembly [GO:0042255] GO:0005730; GO:0042255 0 0 0 PF08142;PF04950; Q5XH14 CHOYP_VATC1.1.1 m.38693 sp VATC1_XENLA 66.754 382 123 3 15 394 1 380 0 529 VATC1_XENLA reviewed V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) atp6v1c1 Xenopus laevis (African clawed frog) 382 ATP hydrolysis coupled proton transport [GO:0015991] GO:0015078; GO:0015991; GO:0033180 0 0 cd14785; PF03223; Q5XH95 CHOYP_LOC588410.1.1 m.29709 sp SCMC2_XENTR 58.797 449 178 3 12 454 55 502 0 555 SCMC2_XENTR reviewed Calcium-binding mitochondrial carrier protein SCaMC-2 (Small calcium-binding mitochondrial carrier protein 2) (Solute carrier family 25 member 25) slc25a25 scamc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 513 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005509; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF13499;PF00153; Q5XHZ0 CHOYP_TRAP1.1.1 m.60651 sp TRAP1_RAT 60.777 566 216 4 13 574 143 706 0 720 TRAP1_RAT reviewed "Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1)" Trap1 Hsp75 Rattus norvegicus (Rat) 706 negative regulation of cellular respiration [GO:1901856]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; protein folding [GO:0006457]; response to stress [GO:0006950]; translational attenuation [GO:0009386] GO:0005524; GO:0005654; GO:0005743; GO:0005758; GO:0005759; GO:0005811; GO:0006457; GO:0006950; GO:0009386; GO:0019901; GO:0044822; GO:0070062; GO:1901856; GO:1903751 0 0 0 PF00183; Q5XI13 CHOYP_LOC100367612.1.1 m.37487 sp GRWD1_RAT 57.108 415 175 2 44 455 31 445 0 518 GRWD1_RAT reviewed Glutamate-rich WD repeat-containing protein 1 Grwd1 Rattus norvegicus (Rat) 445 0 GO:0005730 0 0 0 PF12265;PF00400; Q5XIN7 CHOYP_POMGNT1.1.1 m.33377 sp PMGT1_RAT 51.52 625 290 3 4 615 29 653 0 677 PMGT1_RAT reviewed "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-)" Pomgnt1 Rattus norvegicus (Rat) 660 protein O-linked glycosylation [GO:0006493] GO:0000139; GO:0006493; GO:0016021; GO:0047223 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03071; Q5XXB5 CHOYP_MSH2.1.1 m.18340 sp MSH2_CHLAE 62.165 896 330 5 8 896 18 911 0 1162 MSH2_CHLAE reviewed DNA mismatch repair protein Msh2 (MutS protein homolog 2) MSH2 Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) 933 cell cycle [GO:0007049]; mismatch repair [GO:0006298] GO:0005524; GO:0006298; GO:0007049; GO:0030983; GO:0032301 0 0 0 PF01624;PF05188;PF05192;PF05190;PF00488; Q5YLM1 CHOYP_INAE.1.1 m.1888 sp DGLA_RAT 45.374 681 348 9 1 672 1 666 0 606 DGLA_RAT reviewed Sn1-specific diacylglycerol lipase alpha (DGL-alpha) (EC 3.1.1.-) (Neural stem cell-derived dendrite regulator) Dagla Nsddr Rattus norvegicus (Rat) 1044 arachidonic acid metabolic process [GO:0019369]; diacylglycerol catabolic process [GO:0046340]; endocannabinoid signaling pathway [GO:0071926]; neuroblast proliferation [GO:0007405]; neurotransmitter biosynthetic process [GO:0042136] GO:0005886; GO:0007405; GO:0016021; GO:0016787; GO:0019369; GO:0042136; GO:0043196; GO:0046340; GO:0046872; GO:0071926 0 0 0 PF01764; Q5ZHN3 CHOYP_WIPI2.1.2 m.9192 sp WIPI2_CHICK 68.071 451 124 6 54 499 1 436 0 611 WIPI2_CHICK reviewed WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) WIPI2 RCJMB04_35d18 Gallus gallus (Chicken) 436 autophagosome assembly [GO:0000045]; mitophagy [GO:0000422]; nucleophagy [GO:0044804]; protein lipidation [GO:0006497]; protein localization to pre-autophagosomal structure [GO:0034497] GO:0000045; GO:0000422; GO:0005654; GO:0005776; GO:0005829; GO:0006497; GO:0010314; GO:0019898; GO:0032266; GO:0034045; GO:0034497; GO:0043234; GO:0044804; GO:0080025 0 0 0 0 Q5ZHN3 CHOYP_WIPI2.2.2 m.58195 sp WIPI2_CHICK 74.684 395 88 6 41 430 1 388 0 601 WIPI2_CHICK reviewed WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) WIPI2 RCJMB04_35d18 Gallus gallus (Chicken) 436 autophagosome assembly [GO:0000045]; mitophagy [GO:0000422]; nucleophagy [GO:0044804]; protein lipidation [GO:0006497]; protein localization to pre-autophagosomal structure [GO:0034497] GO:0000045; GO:0000422; GO:0005654; GO:0005776; GO:0005829; GO:0006497; GO:0010314; GO:0019898; GO:0032266; GO:0034045; GO:0034497; GO:0043234; GO:0044804; GO:0080025 0 0 0 0 Q5ZHV2 CHOYP_NAA35.1.1 m.60092 sp NAA35_CHICK 58.037 703 294 1 25 727 24 725 0 855 NAA35_CHICK reviewed "N-alpha-acetyltransferase 35, NatC auxiliary subunit (Protein MAK10 homolog)" NAA35 MAK10 RCJMB04_32o21 Gallus gallus (Chicken) 725 negative regulation of apoptotic process [GO:0043066]; smooth muscle cell proliferation [GO:0048659] GO:0005737; GO:0031417; GO:0043066; GO:0048659 0 0 0 PF04112; Q5ZI67 CHOYP_NHLC2.1.1 m.7990 sp NHLC2_CHICK 46.993 715 352 10 7 697 9 720 0 643 NHLC2_CHICK reviewed NHL repeat-containing protein 2 NHLRC2 RCJMB04_29n5 Gallus gallus (Chicken) 727 cell redox homeostasis [GO:0045454] GO:0005623; GO:0045454 0 0 0 PF01436;PF13905; Q5ZIE6 CHOYP_NEMVEDRAFT_V1G182319.1.1 m.5048 sp ULA1_CHICK 54.803 458 193 3 2 459 92 535 0 536 ULA1_CHICK reviewed NEDD8-activating enzyme E1 regulatory subunit (APP-BP1) (Amyloid protein-binding protein 1) NAE1 APPBP1 RCJMB04_27g6 Gallus gallus (Chicken) 535 protein neddylation [GO:0045116] GO:0005634; GO:0005829; GO:0019781; GO:0045116 PATHWAY: Protein modification; protein neddylation. 0 0 PF00899; Q5ZIH0 CHOYP_INT11.1.1 m.29494 sp INT11_CHICK 75.336 596 140 6 4 597 3 593 0 948 INT11_CHICK reviewed Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) CPSF3L INTS11 RCJMB04_26e19 Gallus gallus (Chicken) 600 snRNA processing [GO:0016180] GO:0016180; GO:0016787; GO:0032039 0 0 0 PF10996;PF16661;PF07521; Q5ZIJ9 CHOYP_PHUM_PHUM516040.1.1 m.55603 sp MIB2_CHICK 49.11 955 425 11 1 903 9 954 0 918 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q5ZIP4 CHOYP_XRN2.1.1 m.13943 sp XRN2_CHICK 63.29 839 294 8 1 837 1 827 0 1064 XRN2_CHICK reviewed 5'-3' exoribonuclease 2 (EC 3.1.13.-) XRN2 RCJMB04_24h23 Gallus gallus (Chicken) 949 "cell growth [GO:0016049]; DNA catabolic process, exonucleolytic [GO:0000738]; DNA-templated transcription, termination [GO:0006353]; mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]" GO:0000738; GO:0001147; GO:0004534; GO:0005730; GO:0006353; GO:0006355; GO:0006397; GO:0007283; GO:0008409; GO:0016020; GO:0016049; GO:0016235; GO:0044822; GO:0046872 0 0 0 PF03159; Q5ZIT8 CHOYP_TAF2.1.1 m.26474 sp TAF2_CHICK 53.81 643 270 7 1 639 472 1091 0 689 TAF2_CHICK reviewed Transcription initiation factor TFIID subunit 2 (TBP-associated factor 150 kDa) (Transcription initiation factor TFIID 150 kDa subunit) (TAF(II)150) (TAFII-150) (TAFII150) TAF2 RCJMB04_23j21 Gallus gallus (Chicken) 1168 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001129; GO:0003682; GO:0005669; GO:0008237; GO:0008270; GO:0043565; GO:0044212; GO:0045944 0 0 0 PF01433; Q5ZJ75 CHOYP_LOC578765.1.1 m.57168 sp SL9A8_CHICK 60 530 204 5 85 607 44 572 0 637 SL9A8_CHICK reviewed Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) 0 Gallus gallus (Chicken) 574 regulation of pH [GO:0006885] GO:0000139; GO:0006885; GO:0015385; GO:0016021 0 0 0 PF00999; Q5ZJ85 CHOYP_PRPF3.1.1 m.736 sp PRPF3_CHICK 56.358 692 240 14 1 639 1 683 0 684 PRPF3_CHICK reviewed U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) PRPF3 RCJMB04_20b24 Gallus gallus (Chicken) 684 "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000398; GO:0005634; GO:0005681; GO:0016607; GO:0046540 0 0 0 PF06544;PF08572;PF01480; Q5ZJB4 CHOYP_IKKA.3.6 m.36600 sp IKKA_CHICK 44.801 654 347 7 10 658 27 671 0 564 IKKA_CHICK reviewed Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) CHUK IKKA RCJMB04_19h23 Gallus gallus (Chicken) 759 cellular response to tumor necrosis factor [GO:0071356]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0008384; GO:0042803; GO:0045944; GO:0046982; GO:0071356 0 0 0 PF12179;PF00069; Q5ZJB4 CHOYP_IKKA.5.6 m.62969 sp IKKA_CHICK 42.049 742 390 11 26 737 27 758 0 572 IKKA_CHICK reviewed Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) CHUK IKKA RCJMB04_19h23 Gallus gallus (Chicken) 759 cellular response to tumor necrosis factor [GO:0071356]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0008384; GO:0042803; GO:0045944; GO:0046982; GO:0071356 0 0 0 PF12179;PF00069; Q5ZJB4 CHOYP_IKKA.6.6 m.63662 sp IKKA_CHICK 41.914 742 395 11 10 725 27 758 0 573 IKKA_CHICK reviewed Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) CHUK IKKA RCJMB04_19h23 Gallus gallus (Chicken) 759 cellular response to tumor necrosis factor [GO:0071356]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0008384; GO:0042803; GO:0045944; GO:0046982; GO:0071356 0 0 0 PF12179;PF00069; Q5ZJB4 CHOYP_IKKB.1.1 m.35704 sp IKKA_CHICK 41.24 742 397 11 10 722 27 758 0 556 IKKA_CHICK reviewed Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) CHUK IKKA RCJMB04_19h23 Gallus gallus (Chicken) 759 cellular response to tumor necrosis factor [GO:0071356]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0008384; GO:0042803; GO:0045944; GO:0046982; GO:0071356 0 0 0 PF12179;PF00069; Q5ZJK1 CHOYP_THOC5.1.1 m.12880 sp THOC5_CHICK 48.276 667 330 6 40 694 35 698 0 647 THOC5_CHICK reviewed THO complex subunit 5 homolog THOC5 RCJMB04_17i18 Gallus gallus (Chicken) 698 "monocyte differentiation [GO:0030224]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; RNA splicing [GO:0008380]; viral mRNA export from host cell nucleus [GO:0046784]" GO:0000228; GO:0000445; GO:0000781; GO:0003729; GO:0005654; GO:0005737; GO:0006397; GO:0006406; GO:0008380; GO:0030224; GO:0032786; GO:0046784; GO:2000002 0 0 0 PF09766; Q5ZJK8 CHOYP_TCPH.1.1 m.7312 sp TCPH_CHICK 79.245 530 110 0 21 550 1 530 0 885 TCPH_CHICK reviewed T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) CCT7 RCJMB04_17g3 Gallus gallus (Chicken) 553 binding of sperm to zona pellucida [GO:0007339]; protein folding [GO:0006457]; toxin transport [GO:1901998] GO:0002199; GO:0005524; GO:0005739; GO:0005832; GO:0005874; GO:0006457; GO:0007339; GO:0044297; GO:0070062; GO:1901998 0 0 cd03340; PF00118; Q5ZJL4 CHOYP_CLP1.1.1 m.11641 sp CLP1_CHICK 62.085 422 156 1 3 424 8 425 0 583 CLP1_CHICK reviewed Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1) CLP1 RCJMB04_17f4 Gallus gallus (Chicken) 425 "cerebellar cortex development [GO:0021695]; mRNA cleavage [GO:0006379]; mRNA polyadenylation [GO:0006378]; siRNA loading onto RISC involved in RNA interference [GO:0035087]; targeting of mRNA for destruction involved in RNA interference [GO:0030423]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000214; GO:0005524; GO:0005634; GO:0005737; GO:0005849; GO:0006378; GO:0006379; GO:0006388; GO:0021695; GO:0030423; GO:0035087; GO:0046404; GO:0051731; GO:0051733; GO:0051736 0 0 0 PF06807;PF16573;PF16575; Q5ZJP5 CHOYP_PHUM_PHUM137710.1.1 m.19548 sp FND3A_CHICK 39.116 1199 646 24 129 1272 27 1196 0 813 FND3A_CHICK reviewed Fibronectin type-III domain-containing protein 3a FNDC3A FNDC3 RCJMB04_16k12 Gallus gallus (Chicken) 1198 0 GO:0000139; GO:0016021 0 0 0 PF00041; Q5ZJY3 CHOYP_GARL3.1.1 m.25947 sp GARL3_CHICK 52.109 877 368 15 56 892 24 888 0 891 GARL3_CHICK reviewed GTPase-activating Rap/Ran-GAP domain-like protein 3 GARNL3 RCJMB04_14h1 Gallus gallus (Chicken) 917 regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0051056 0 0 0 PF00780;PF02145; Q5ZK62 CHOYP_ENO.1.2 m.7680 sp ACAP2_CHICK 48.348 817 370 13 1 805 1 777 0 749 ACAP2_CHICK reviewed "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)" ACAP2 CENTB2 RCJMB04_12p24 Gallus gallus (Chicken) 781 cellular response to nerve growth factor stimulus [GO:1990090]; protein localization to endosome [GO:0036010] GO:0005096; GO:0010008; GO:0036010; GO:0046872; GO:1990090 0 0 0 PF12796;PF01412;PF00169; Q5ZKA2 CHOYP_SYIM.1.2 m.17804 sp SYIM_CHICK 47.955 807 397 10 39 832 44 840 0 761 SYIM_CHICK reviewed "Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)" IARS2 RCJMB04_12b19 Gallus gallus (Chicken) 1000 isoleucyl-tRNA aminoacylation [GO:0006428] GO:0000049; GO:0002161; GO:0004822; GO:0005524; GO:0005739; GO:0005759; GO:0005829; GO:0006428 0 0 cd07960; PF08264;PF00133; Q5ZKC1 CHOYP_EIF2A.1.1 m.12752 sp EIF2A_CHICK 52.34 577 260 7 5 569 1 574 0 591 EIF2A_CHICK reviewed Eukaryotic translation initiation factor 2A (eIF-2A) EIF2A RCJMB04_11n11 Gallus gallus (Chicken) 586 regulation of translation [GO:0006417]; ribosome assembly [GO:0042255] GO:0000049; GO:0003743; GO:0005737; GO:0005850; GO:0006417; GO:0042255; GO:0043022 0 0 0 PF08662; Q5ZKD7 CHOYP_BRAFLDRAFT_119350.1.1 m.50169 sp MOV10_CHICK 43.059 922 480 17 169 1066 65 965 0 709 MOV10_CHICK reviewed Putative helicase MOV-10 (EC 3.6.4.13) MOV10 RCJMB04_11i10 Gallus gallus (Chicken) 967 gene silencing by miRNA [GO:0035195]; mRNA cleavage involved in gene silencing by miRNA [GO:0035279] GO:0000932; GO:0003723; GO:0004386; GO:0005524; GO:0035195; GO:0035279 0 0 0 0 Q5ZKH3 CHOYP_EED.1.1 m.66517 sp EED_CHICK 58.411 428 168 4 13 433 22 446 0 528 EED_CHICK reviewed Polycomb protein EED EED RCJMB04_10n8 Gallus gallus (Chicken) 446 "positive regulation of histone H3-K27 methylation [GO:0061087]; regulation of gene expression by genetic imprinting [GO:0006349]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001739; GO:0003682; GO:0005730; GO:0006349; GO:0006351; GO:0006355; GO:0035098; GO:0042054; GO:0045120; GO:0061087 0 0 0 PF00400; Q5ZKI0 CHOYP_LOC100533283.1.1 m.54357 sp KCC2D_CHICK 77.593 482 98 5 1 478 1 476 0 794 KCC2D_CHICK reviewed Calcium/calmodulin-dependent protein kinase type II delta chain (CaM kinase II subunit delta) (CaM-kinase II delta chain) (CaMK-II subunit delta) (EC 2.7.11.17) CAMK2D RCJMB04_10k21 Gallus gallus (Chicken) 479 0 GO:0004683; GO:0005524 0 0 0 PF08332;PF00069; Q5ZKI4 CHOYP_BRAFLDRAFT_92063.1.2 m.677 sp CCD93_CHICK 61.897 601 195 5 35 602 14 613 0 743 CCD93_CHICK reviewed Coiled-coil domain-containing protein 93 CCDC93 RCJMB04_10i21 Gallus gallus (Chicken) 617 Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] GO:0005769; GO:0006893; GO:0015031 0 0 0 PF09762; Q5ZKI4 CHOYP_BRAFLDRAFT_92063.2.2 m.33484 sp CCD93_CHICK 64.725 601 207 4 156 752 14 613 0 785 CCD93_CHICK reviewed Coiled-coil domain-containing protein 93 CCDC93 RCJMB04_10i21 Gallus gallus (Chicken) 617 Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] GO:0005769; GO:0006893; GO:0015031 0 0 0 PF09762; Q5ZKJ0 CHOYP_BRAFLDRAFT_238322.1.1 m.24041 sp CLP1L_CHICK 58.79 529 204 5 2 518 4 530 0 654 CLP1L_CHICK reviewed Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein) CLPTM1L RCJMB04_10g15 Gallus gallus (Chicken) 536 apoptotic process [GO:0006915] GO:0006915; GO:0016021 0 0 0 PF05602; Q5ZKK5 CHOYP_LOC100366442.1.4 m.6288 sp ODFP2_CHICK 39.586 821 438 9 9 788 6 809 0 542 ODFP2_CHICK reviewed Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 RCJMB04_10e12 Gallus gallus (Chicken) 822 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0005815; GO:0005874; GO:0005929; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q5ZKK5 CHOYP_LOC100366442.4.4 m.57249 sp ODFP2_CHICK 41.126 817 460 8 9 817 6 809 0 572 ODFP2_CHICK reviewed Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 RCJMB04_10e12 Gallus gallus (Chicken) 822 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0005815; GO:0005874; GO:0005929; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q5ZKV8 CHOYP_KIF2A.2.2 m.62686 sp KIF2A_CHICK 58.547 702 260 10 2 676 5 702 0 815 KIF2A_CHICK reviewed Kinesin-like protein KIF2A KIF2A RCJMB04_9a7 Gallus gallus (Chicken) 706 cell differentiation [GO:0030154]; cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; nervous system development [GO:0007399] GO:0000922; GO:0003777; GO:0005524; GO:0005737; GO:0005815; GO:0005871; GO:0005874; GO:0007018; GO:0007052; GO:0007067; GO:0007399; GO:0016887; GO:0030154; GO:0051301 0 0 0 PF00225; Q5ZL00 CHOYP_BRAFLDRAFT_72541.1.2 m.13652 sp EMC1_CHICK 37.664 993 550 17 29 977 16 983 0 644 EMC1_CHICK reviewed ER membrane protein complex subunit 1 EMC1 RCJMB04_8i12 Gallus gallus (Chicken) 983 protein folding in endoplasmic reticulum [GO:0034975] GO:0016021; GO:0034975; GO:0072546 0 0 0 PF07774;PF13360; Q5ZL12 CHOYP_BRAFLDRAFT_276229.1.1 m.37508 sp PPR21_CHICK 44.661 768 411 5 6 770 10 766 0 617 PPR21_CHICK reviewed Protein phosphatase 1 regulatory subunit 21 (Coiled-coil domain-containing protein 128) (KLRAQ motif-containing protein 1) PPP1R21 CCDC128 KLRAQ1 RCJMB04_8e10 Gallus gallus (Chicken) 779 0 GO:0019902 0 0 0 PF10205;PF10212; Q5ZL16 CHOYP_WIPI3.1.1 m.13956 sp WIPI3_CHICK 77.843 343 76 0 39 381 1 343 0 585 WIPI3_CHICK reviewed WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45B) WDR45B WIPI3 RCJMB04_8d21 Gallus gallus (Chicken) 344 autophagosome assembly [GO:0000045]; mitophagy [GO:0000422]; nucleophagy [GO:0044804]; protein lipidation [GO:0006497]; protein localization to pre-autophagosomal structure [GO:0034497] GO:0000045; GO:0000422; GO:0005829; GO:0006497; GO:0019898; GO:0032266; GO:0034045; GO:0034497; GO:0044804; GO:0080025 0 0 0 0 Q5ZL57 CHOYP_COPD.1.1 m.37389 sp COPD_CHICK 63.922 510 183 1 1 509 1 510 0 699 COPD_CHICK reviewed Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) ARCN1 COPD RCJMB04_7j3 Gallus gallus (Chicken) 510 "adult locomotory behavior [GO:0008344]; cerebellar Purkinje cell layer maturation [GO:0021691]; pigmentation [GO:0043473]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005783; GO:0006890; GO:0008344; GO:0015031; GO:0021691; GO:0030126; GO:0043473; GO:0044822 0 0 0 PF00928;PF01217; Q5ZL91 CHOYP_INT7.1.1 m.14480 sp INT7_CHICK 41.325 951 506 17 19 946 11 932 0 711 INT7_CHICK reviewed Integrator complex subunit 7 (Int7) INTS7 RCJMB04_7c6 Gallus gallus (Chicken) 961 cellular response to DNA damage stimulus [GO:0006974]; snRNA processing [GO:0016180] GO:0005694; GO:0006974; GO:0016180; GO:0032039 0 0 0 0 Q5ZLA6 CHOYP_MYO1C.2.3 m.26093 sp MYO1C_CHICK 56.43 1042 426 7 1 1034 1 1022 0 1226 MYO1C_CHICK reviewed Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) MYO1C RCJMB04_6o17 Gallus gallus (Chicken) 1028 0 GO:0001726; GO:0003774; GO:0005524; GO:0016023; GO:0016459; GO:0060171 0 0 0 PF00063;PF06017; Q5ZLD7 CHOYP_VPS53.1.1 m.51625 sp VPS53_CHICK 64.91 835 270 9 19 845 12 831 0 1103 VPS53_CHICK reviewed Vacuolar protein sorting-associated protein 53 homolog VPS53 RCJMB04_6k3 Gallus gallus (Chicken) 831 "endocytic recycling [GO:0032456]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000938; GO:0005829; GO:0010008; GO:0015031; GO:0032456; GO:0042147; GO:0055037; GO:1990745 0 0 0 PF04100; Q5ZLG9 CHOYP_WDR59.4.5 m.55404 sp WDR59_CHICK 42.412 995 524 17 1 973 1 968 0 770 WDR59_CHICK reviewed WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) 973 cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034198; GO:0061700 0 0 0 PF00400; Q5ZLG9 CHOYP_WDR59.5.5 m.57997 sp WDR59_CHICK 41.699 1036 515 18 1 1015 1 968 0 771 WDR59_CHICK reviewed WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) 973 cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034198; GO:0061700 0 0 0 PF00400; Q5ZLK1 CHOYP_DCA13.1.1 m.6709 sp DCA13_CHICK 67.706 449 136 2 1 444 1 445 0 654 DCA13_CHICK reviewed DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) DCAF13 WDSOF1 RCJMB04_5m12 Gallus gallus (Chicken) 445 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; protein ubiquitination [GO:0016567]" GO:0000462; GO:0005730; GO:0016567; GO:0032040; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF04158;PF00400; Q5ZLM0 CHOYP_CDC73.1.1 m.36157 sp CDC73_CHICK 63.06 536 175 11 8 528 4 531 0 635 CDC73_CHICK reviewed Parafibromin (Cell division cycle protein 73 homolog) CDC73 RCJMB04_5j4 Gallus gallus (Chicken) 531 cell cycle [GO:0007049]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; histone H2B ubiquitination [GO:0033523]; histone monoubiquitination [GO:0010390]; mRNA polyadenylation [GO:0006378]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; stem cell population maintenance [GO:0019827]; transcription elongation from RNA polymerase II promoter [GO:0006368] GO:0000122; GO:0000784; GO:0000993; GO:0001711; GO:0005634; GO:0005737; GO:0006368; GO:0006378; GO:0007049; GO:0008285; GO:0010390; GO:0016593; GO:0019827; GO:0030177; GO:0031442; GO:0031648; GO:0032968; GO:0033523; GO:0045638; GO:0045944; GO:0048147; GO:0050680; GO:0071222; GO:2000134 0 0 0 PF05179;PF16050; Q5ZLR1 CHOYP_WLS.1.1 m.8995 sp WLS_CHICK 49.639 554 259 7 1 547 1 541 0 554 WLS_CHICK reviewed Protein wntless homolog (Integral membrane protein GPR177) WLS GPR177 RCJMB04_5c7 Gallus gallus (Chicken) 541 multicellular organism development [GO:0007275]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] GO:0000139; GO:0007275; GO:0016021; GO:0016055; GO:0030177; GO:0030659; GO:0061357 0 0 0 0 Q5ZLT0 CHOYP_XPO7.1.1 m.50167 sp XPO7_CHICK 73.333 1080 274 9 5 1081 6 1074 0 1650 XPO7_CHICK reviewed Exportin-7 XPO7 RCJMB04_4p4 Gallus gallus (Chicken) 1087 protein export from nucleus [GO:0006611] GO:0005049; GO:0005643; GO:0005737; GO:0006611; GO:0008536 0 0 0 PF03810; Q5ZLW3 CHOYP_LOC100374358.1.1 m.59032 sp DYM_CHICK 51.852 675 310 8 1 666 1 669 0 690 DYM_CHICK reviewed Dymeclin DYM RCJMB04_4k4 Gallus gallus (Chicken) 669 bone development [GO:0060348]; Golgi organization [GO:0007030] GO:0005794; GO:0007030; GO:0060348 0 0 0 0 Q5ZM16 CHOYP_RBM22.1.1 m.43645 sp RBM22_CHICK 69.655 435 101 6 7 433 1 412 0 572 RBM22_CHICK reviewed Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) RBM22 RCJMB04_3g16 Gallus gallus (Chicken) 420 "cellular response to drug [GO:0035690]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of RNA splicing [GO:0033120]; spliceosomal snRNP assembly [GO:0000387]" GO:0000166; GO:0000387; GO:0000974; GO:0005487; GO:0005634; GO:0005737; GO:0017070; GO:0033120; GO:0035690; GO:0036002; GO:0045292; GO:0046872; GO:0071006; GO:0071007; GO:0090316 0 0 0 PF00076; Q5ZM55 CHOYP_FEM1B.1.1 m.54345 sp FEM1B_CHICK 50.637 628 307 3 18 643 1 627 0 632 FEM1B_CHICK reviewed Protein fem-1 homolog B (FEM1b) (FEM1-beta) FEM1B RCJMB04_3b14 Gallus gallus (Chicken) 627 apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001] GO:0005634; GO:0005737; GO:0006915; GO:0016567; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00023;PF12796; Q5ZM73 CHOYP_BRAFLDRAFT_93126.2.3 m.15451 sp MIRO1_CHICK 59.135 624 237 7 4 622 2 612 0 753 MIRO1_CHICK reviewed Mitochondrial Rho GTPase 1 (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1) RHOT1 RCJMB04_2p2 Gallus gallus (Chicken) 619 cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion transport along microtubule [GO:0047497]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005509; GO:0005525; GO:0007264; GO:0019725; GO:0031307; GO:0047497; GO:0097345 0 0 0 PF08355;PF08356;PF00071; Q5ZMH1 CHOYP_LOC100372339.1.2 m.5168 sp SEPT2_CHICK 70.411 365 84 3 270 634 5 345 0 542 SEPT2_CHICK reviewed Septin-2 SEPT2 RCJMB04_2a21 Gallus gallus (Chicken) 349 cell division [GO:0051301]; cilium assembly [GO:0042384]; mitotic nuclear division [GO:0007067]; smoothened signaling pathway [GO:0007224] GO:0005525; GO:0005737; GO:0005819; GO:0005938; GO:0007067; GO:0007224; GO:0030496; GO:0032154; GO:0042384; GO:0051301; GO:0060170 0 0 cd01850; PF00735; Q5ZMH1 CHOYP_LOC100372339.2.2 m.14385 sp SEPT2_CHICK 70.33 364 84 3 45 408 6 345 0 532 SEPT2_CHICK reviewed Septin-2 SEPT2 RCJMB04_2a21 Gallus gallus (Chicken) 349 cell division [GO:0051301]; cilium assembly [GO:0042384]; mitotic nuclear division [GO:0007067]; smoothened signaling pathway [GO:0007224] GO:0005525; GO:0005737; GO:0005819; GO:0005938; GO:0007067; GO:0007224; GO:0030496; GO:0032154; GO:0042384; GO:0051301; GO:0060170 0 0 cd01850; PF00735; Q5ZMP6 CHOYP_AP2M1.1.1 m.25996 sp AP2M1_CHICK 86.986 438 52 1 1 438 1 433 0 808 AP2M1_CHICK reviewed AP-2 complex subunit mu (AP-2 mu chain) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) AP2M1 RCJMB04_1h23 Gallus gallus (Chicken) 433 endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; negative regulation of protein localization to plasma membrane [GO:1903077] GO:0005048; GO:0005739; GO:0005886; GO:0005905; GO:0006886; GO:0006897; GO:0008289; GO:0030131; GO:0070062; GO:1903077 0 0 0 PF00928;PF01217; Q5ZMT7 CHOYP_LOC100369003.2.2 m.16621 sp ADCK1_CHICK 57.395 453 189 3 1 449 59 511 0 545 ADCK1_CHICK reviewed Uncharacterized aarF domain-containing protein kinase 1 (EC 2.7.11.-) ADCK1 RCJMB04_1d9 Gallus gallus (Chicken) 519 0 GO:0004674; GO:0005524; GO:0005576 0 0 0 PF03109; Q60560 CHOYP_LOC591177.1.1 m.1475 sp SMBP2_MESAU 47.818 1031 461 17 2 1005 5 985 0 908 SMBP2_MESAU reviewed DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (Insulin II gene enhancer-binding protein) (RIPE3B-binding complex 3B2 p110 subunit) (RIP-1) IGHMBP2 RIP1 SMUBP2 Mesocricetus auratus (Golden hamster) 989 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0000049; GO:0003677; GO:0003723; GO:0005524; GO:0005634; GO:0005737; GO:0006351; GO:0006357; GO:0006412; GO:0008094; GO:0008186; GO:0008270; GO:0030424; GO:0030529; GO:0032575; GO:0043022; GO:0043141; GO:0043621 0 0 0 PF01424;PF01428; Q60649 CHOYP_CLPB.1.3 m.14233 sp CLPB_MOUSE 52.007 548 200 6 71 556 118 664 0 556 CLPB_MOUSE reviewed Caseinolytic peptidase B protein homolog (EC 3.6.1.3) (Suppressor of potassium transport defect 3) Clpb Skd3 Mus musculus (Mouse) 677 cellular response to heat [GO:0034605] GO:0005524; GO:0005739; GO:0016887; GO:0034605 0 0 0 PF07724;PF12796;PF10431; Q60649 CHOYP_CLPB.2.3 m.19559 sp CLPB_MOUSE 61.314 548 203 4 90 629 118 664 0 695 CLPB_MOUSE reviewed Caseinolytic peptidase B protein homolog (EC 3.6.1.3) (Suppressor of potassium transport defect 3) Clpb Skd3 Mus musculus (Mouse) 677 cellular response to heat [GO:0034605] GO:0005524; GO:0005739; GO:0016887; GO:0034605 0 0 0 PF07724;PF12796;PF10431; Q60675 CHOYP_LAMA2.1.1 m.10439 sp LAMA2_MOUSE 35.264 3176 1849 69 26 3087 34 3116 0 1863 LAMA2_MOUSE reviewed Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) Lama2 Mus musculus (Mouse) 3118 "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; myelination in peripheral nervous system [GO:0022011]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]" GO:0005576; GO:0005604; GO:0005605; GO:0007155; GO:0007411; GO:0022011; GO:0030155; GO:0030198; GO:0030334; GO:0032224; GO:0042383; GO:0043197; GO:0045995; GO:0070062 0 0 0 PF00052;PF00053;PF00054;PF02210;PF06008;PF06009;PF00055; Q60676 CHOYP_LOC100119577.1.1 m.47861 sp PPP5_MOUSE 63.636 495 180 0 5 499 2 496 0 703 PPP5_MOUSE reviewed Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PPT) Ppp5c Mus musculus (Mouse) 499 cellular response to cadmium ion [GO:0071276]; cellular response to hydrogen peroxide [GO:0070301]; histone dephosphorylation [GO:0016576]; negative regulation of neuron death [GO:1901215]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of glucocorticoid receptor signaling pathway [GO:2000324]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein heterooligomerization [GO:0051291]; response to lead ion [GO:0010288]; response to morphine [GO:0043278] GO:0001933; GO:0003723; GO:0004721; GO:0004871; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0010288; GO:0016576; GO:0042802; GO:0043123; GO:0043204; GO:0043231; GO:0043234; GO:0043278; GO:0043531; GO:0046872; GO:0051291; GO:0070301; GO:0071276; GO:1901215; GO:1990635; GO:2000324 0 0 0 PF00149;PF08321;PF00515; Q60972 CHOYP_RBBP4.1.1 m.62913 sp RBBP4_MOUSE 90.408 417 38 1 1 417 1 415 0 791 RBBP4_MOUSE reviewed Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48) Rbbp4 Rbap48 Mus musculus (Mouse) 425 "ATP-dependent chromatin remodeling [GO:0043044]; cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; chromatin remodeling [GO:0006338]; chromatin silencing at rDNA [GO:0000183]; covalent chromatin modification [GO:0016569]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; transcription, DNA-templated [GO:0006351]" GO:0000183; GO:0000790; GO:0000978; GO:0000980; GO:0005634; GO:0005654; GO:0006260; GO:0006335; GO:0006336; GO:0006338; GO:0006351; GO:0007049; GO:0008094; GO:0016569; GO:0016581; GO:0016589; GO:0031497; GO:0033186; GO:0035098; GO:0042826; GO:0043044; GO:0043234 0 0 0 PF12265;PF00400; Q60HE2 CHOYP_ODO1.2.2 m.23540 sp ODO1_MACFA 59.238 1023 368 12 4 1000 20 1019 0 1216 ODO1_MACFA reviewed "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" OGDH QccE-15394 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 1023 generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099] GO:0004591; GO:0005759; GO:0006091; GO:0006096; GO:0006099; GO:0030976; GO:0031966; GO:0046872 0 0 0 PF16078;PF00676;PF16870;PF02779; Q60HE9 CHOYP_LOC100176799.1.1 m.3132 sp MA2B1_MACFA 48.335 991 454 18 1 981 63 1005 0 882 MA2B1_MACFA reviewed Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) MAN2B1 QmoA-10471 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 1012 mannose metabolic process [GO:0006013] GO:0004559; GO:0005764; GO:0006013; GO:0008270; GO:0030246 0 0 0 PF09261;PF01074;PF07748; Q60HG7 CHOYP_CGL.1.2 m.31960 sp CGL_MACFA 68.718 390 121 1 7 396 15 403 0 563 CGL_MACFA reviewed Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) CTH QccE-22305 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 405 cellular amino acid biosynthetic process [GO:0008652]; cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; negative regulation of apoptotic process [GO:0043066]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; protein sulfhydration [GO:0044524] GO:0004123; GO:0005737; GO:0008652; GO:0018272; GO:0019344; GO:0030170; GO:0043066; GO:0043123; GO:0044524; GO:0044540; GO:0051092; GO:0070814; GO:0080146 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. 0 cd00614; PF01053; Q60HG7 CHOYP_CGL.2.2 m.46932 sp CGL_MACFA 68.462 390 122 1 7 396 15 403 0 562 CGL_MACFA reviewed Cystathionine gamma-lyase (EC 4.4.1.1) (Cysteine-protein sulfhydrase) (Gamma-cystathionase) CTH QccE-22305 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 405 cellular amino acid biosynthetic process [GO:0008652]; cysteine biosynthetic process [GO:0019344]; hydrogen sulfide biosynthetic process [GO:0070814]; negative regulation of apoptotic process [GO:0043066]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine [GO:0018272]; protein sulfhydration [GO:0044524] GO:0004123; GO:0005737; GO:0008652; GO:0018272; GO:0019344; GO:0030170; GO:0043066; GO:0043123; GO:0044524; GO:0044540; GO:0051092; GO:0070814; GO:0080146 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. 0 cd00614; PF01053; Q61035 CHOYP_SYHC.1.1 m.65924 sp SYHC_MOUSE 66.803 488 157 1 16 503 17 499 0 679 SYHC_MOUSE reviewed "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)" Hars Mus musculus (Mouse) 509 histidyl-tRNA aminoacylation [GO:0006427]; mitochondrial translation [GO:0032543] GO:0004821; GO:0005524; GO:0005737; GO:0005739; GO:0006427; GO:0032543 0 0 cd00859; PF03129;PF00458; Q61115 CHOYP_PHUM_PHUM390440.1.1 m.27133 sp PTC1_MOUSE 46.945 1244 614 15 12 1236 32 1248 0 1091 PTC1_MOUSE reviewed Protein patched homolog 1 (PTC) (PTC1) Ptch1 Ptch Mus musculus (Mouse) 1434 "brain development [GO:0007420]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell differentiation involved in kidney development [GO:0061005]; cell fate determination [GO:0001709]; cell proliferation involved in metanephros development [GO:0072203]; cellular response to cholesterol [GO:0071397]; dorsal/ventral neural tube patterning [GO:0021904]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; epidermal cell fate specification [GO:0009957]; epidermis development [GO:0008544]; glucose homeostasis [GO:0042593]; heart morphogenesis [GO:0003007]; hindlimb morphogenesis [GO:0035137]; in utero embryonic development [GO:0001701]; keratinocyte proliferation [GO:0043616]; limb morphogenesis [GO:0035108]; mammary gland development [GO:0030879]; mammary gland duct morphogenesis [GO:0060603]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell division [GO:0051782]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural plate axis specification [GO:0021997]; neural tube closure [GO:0001843]; neural tube formation [GO:0001841]; neural tube patterning [GO:0021532]; organ morphogenesis [GO:0009887]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of epidermal cell differentiation [GO:0045606]; positive regulation of transcription, DNA-templated [GO:0045893]; protein processing [GO:0016485]; protein targeting to plasma membrane [GO:0072661]; regulation of cell proliferation [GO:0042127]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization [GO:0032880]; regulation of smoothened signaling pathway [GO:0008589]; response to chlorate [GO:0010157]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]; somite development [GO:0061053]; spinal cord motor neuron differentiation [GO:0021522]" GO:0000122; GO:0001658; GO:0001701; GO:0001709; GO:0001841; GO:0001843; GO:0003007; GO:0005113; GO:0005119; GO:0005576; GO:0005794; GO:0005886; GO:0005887; GO:0005901; GO:0007165; GO:0007224; GO:0007346; GO:0007389; GO:0007420; GO:0008158; GO:0008201; GO:0008270; GO:0008285; GO:0008544; GO:0008589; GO:0009612; GO:0009887; GO:0009953; GO:0009957; GO:0010157; GO:0010875; GO:0014069; GO:0015485; GO:0016485; GO:0021522; GO:0021532; GO:0021904; GO:0021997; GO:0030326; GO:0030332; GO:0030496; GO:0030879; GO:0032355; GO:0032403; GO:0032526; GO:0032880; GO:0035108; GO:0035137; GO:0040008; GO:0040015; GO:0042127; GO:0042493; GO:0042593; GO:0043231; GO:0043433; GO:0043616; GO:0044294; GO:0044295; GO:0045606; GO:0045668; GO:0045879; GO:0045892; GO:0045893; GO:0048471; GO:0048568; GO:0050680; GO:0051782; GO:0060037; GO:0060603; GO:0060644; GO:0060831; GO:0061005; GO:0061053; GO:0071397; GO:0072203; GO:0072372; GO:0072661; GO:0097108 0 0 0 PF02460;PF12349; Q61143 CHOYP_TRPC6.2.2 m.56694 sp TRPC6_MOUSE 37.349 913 488 16 6 882 56 920 0 597 TRPC6_MOUSE reviewed Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel) (Transient receptor protein 6) (TRP-6) Trpc6 Trp6 Trrp6 Mus musculus (Mouse) 930 aging [GO:0007568]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; manganese ion transport [GO:0006828]; negative regulation of dendrite morphogenesis [GO:0050774]; neuron differentiation [GO:0030182]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; single fertilization [GO:0007338] GO:0005216; GO:0005737; GO:0005886; GO:0005887; GO:0006828; GO:0007204; GO:0007338; GO:0007568; GO:0010800; GO:0015279; GO:0016020; GO:0030182; GO:0032414; GO:0036057; GO:0045666; GO:0050774; GO:0051928; GO:0070301; GO:0070679; GO:0071456 0 0 0 PF12796;PF00520;PF08344; Q61191 CHOYP_BRAFLDRAFT_122422.2.2 m.61520 sp HCFC1_MOUSE 54.162 853 232 26 7 735 18 835 0 786 HCFC1_MOUSE reviewed Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] Hcfc1 Mus musculus (Mouse) 2045 "cell cycle [GO:0007049]; cellular response to organic cyclic compound [GO:0071407]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of gene expression [GO:0010628]; protein stabilization [GO:0050821]; regulation of protein complex assembly [GO:0043254]; regulation of transcription, DNA-templated [GO:0006355]; release from viral latency [GO:0019046]" GO:0000122; GO:0000123; GO:0001205; GO:0003682; GO:0003713; GO:0005634; GO:0005654; GO:0005671; GO:0005737; GO:0005739; GO:0006355; GO:0007049; GO:0010628; GO:0016020; GO:0019046; GO:0030424; GO:0030425; GO:0042802; GO:0043025; GO:0043254; GO:0043981; GO:0043982; GO:0043984; GO:0043995; GO:0043996; GO:0046972; GO:0048188; GO:0050821; GO:0070461; GO:0070688; GO:0071339; GO:0071407 0 0 0 PF01344; Q61315 CHOYP_APC.1.2 m.16507 sp APC_MOUSE 49.522 836 321 17 3 795 5 782 0 741 APC_MOUSE reviewed Adenomatous polyposis coli protein (Protein APC) (mAPC) Apc Mus musculus (Mouse) 2845 anterior/posterior pattern specification [GO:0009952]; axis specification [GO:0009798]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; canonical Wnt signaling pathway involved in positive regulation of apoptotic process [GO:0044337]; cell cycle arrest [GO:0007050]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; cellular response to DNA damage stimulus [GO:0006974]; chromosome organization [GO:0051276]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral pattern formation [GO:0009953]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint [GO:0007094]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of odontogenesis [GO:0042483]; negative regulation of Wnt signaling pathway [GO:0030178]; pattern specification process [GO:0007389]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of pseudopodium assembly [GO:0031274]; protein complex assembly [GO:0006461]; proximal/distal pattern formation [GO:0009954]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; regulation of epithelial cell differentiation [GO:0030856]; regulation of microtubule-based process [GO:0032886]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoclast differentiation [GO:0045670]; retina development in camera-type eye [GO:0060041]; skin development [GO:0043588]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; Wnt signaling pathway [GO:0016055] GO:0000281; GO:0000776; GO:0001708; GO:0001822; GO:0001942; GO:0002020; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0005886; GO:0005912; GO:0005923; GO:0006461; GO:0006974; GO:0007026; GO:0007050; GO:0007091; GO:0007094; GO:0007389; GO:0007409; GO:0008013; GO:0008017; GO:0008285; GO:0009798; GO:0009952; GO:0009953; GO:0009954; GO:0016055; GO:0016328; GO:0016342; GO:0016477; GO:0019827; GO:0019887; GO:0019901; GO:0030027; GO:0030178; GO:0030334; GO:0030335; GO:0030424; GO:0030426; GO:0030856; GO:0030858; GO:0030877; GO:0031116; GO:0031122; GO:0031253; GO:0031274; GO:0032587; GO:0032886; GO:0033077; GO:0034750; GO:0035019; GO:0042483; GO:0042995; GO:0043065; GO:0043066; GO:0043409; GO:0043588; GO:0044295; GO:0044336; GO:0044337; GO:0045295; GO:0045595; GO:0045597; GO:0045667; GO:0045670; GO:0045732; GO:0045736; GO:0045785; GO:0046716; GO:0048538; GO:0050680; GO:0051010; GO:0051171; GO:0051276; GO:0051726; GO:0051781; GO:0051988; GO:0060041; GO:0060070; GO:0060770; GO:0090090 0 0 0 PF05972;PF05956;PF16689;PF05923;PF00514;PF05937;PF05924; Q61329 CHOYP_LOC100877335.1.1 m.8851 sp ZFHX3_MOUSE 37.592 1221 539 29 333 1455 587 1682 0 732 ZFHX3_MOUSE reviewed Zinc finger homeobox protein 3 (AT motif-binding factor 1) (AT-binding transcription factor 1) (Alpha-fetoprotein enhancer-binding protein) (Zinc finger homeodomain protein 3) (ZFH-3) Zfhx3 Atbf1 Mus musculus (Mouse) 3726 "circadian regulation of gene expression [GO:0032922]; muscle organ development [GO:0007517]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of locomotor rhythm [GO:1904059]; response to transforming growth factor beta [GO:0071559]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001046; GO:0005634; GO:0005654; GO:0005667; GO:0005730; GO:0005737; GO:0005739; GO:0006351; GO:0007517; GO:0008270; GO:0016604; GO:0019899; GO:0032922; GO:0043231; GO:0045893; GO:0071559; GO:1904059 0 0 0 PF00046; Q61371 CHOYP_BRAFLDRAFT_208090.1.1 m.45354 sp IFT88_MOUSE 64.303 846 266 11 7 838 1 824 0 1111 IFT88_MOUSE reviewed Intraflagellar transport protein 88 homolog (Recessive polycystic kidney disease protein Tg737) (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (TgN(Imorpk)737Rpw) Ift88 Tg737 Tg737Rpw TgN737Rpw Ttc10 Mus musculus (Mouse) 824 anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; cardiac muscle cell differentiation [GO:0055007]; cardiac septum morphogenesis [GO:0060411]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; cochlea development [GO:0090102]; cytoplasmic microtubule organization [GO:0031122]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; epidermal stem cell homeostasis [GO:0036334]; epidermis development [GO:0008544]; epithelial cell morphogenesis [GO:0003382]; eye development [GO:0001654]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; heart formation [GO:0060914]; inner ear receptor stereocilium organization [GO:0060122]; kidney development [GO:0001822]; limb development [GO:0060173]; liver development [GO:0001889]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; negative regulation of epithelial cell proliferation [GO:0050680]; nervous system development [GO:0007399]; neural precursor cell proliferation [GO:0061351]; nonmotile primary cilium assembly [GO:0035058]; Notch signaling pathway [GO:0007219]; organ morphogenesis [GO:0009887]; palate development [GO:0060021]; pancreas development [GO:0031016]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; protein localization [GO:0008104]; regulation of autophagosome assembly [GO:2000785]; regulation of cilium assembly [GO:1902017]; regulation of fat cell differentiation [GO:0045598]; regulation of feeding behavior [GO:0060259]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of protein processing [GO:0070613]; regulation of smoothened signaling pathway [GO:0008589]; response to fluid shear stress [GO:0034405]; smoothened signaling pathway [GO:0007224]; spermatid nucleus elongation [GO:0007290]; sperm axoneme assembly [GO:0007288]; spinal cord dorsal/ventral patterning [GO:0021513]; telencephalon development [GO:0021537] GO:0001654; GO:0001822; GO:0001889; GO:0002080; GO:0002081; GO:0003382; GO:0005802; GO:0005813; GO:0005814; GO:0005929; GO:0005930; GO:0007219; GO:0007224; GO:0007288; GO:0007290; GO:0007368; GO:0007399; GO:0007420; GO:0007507; GO:0008104; GO:0008544; GO:0008589; GO:0009887; GO:0009952; GO:0009953; GO:0019894; GO:0021513; GO:0021537; GO:0030324; GO:0030992; GO:0031016; GO:0031122; GO:0031512; GO:0032391; GO:0034405; GO:0035058; GO:0036064; GO:0036334; GO:0042384; GO:0042487; GO:0042733; GO:0043568; GO:0045177; GO:0045598; GO:0048853; GO:0050680; GO:0055007; GO:0060021; GO:0060091; GO:0060122; GO:0060173; GO:0060259; GO:0060271; GO:0060411; GO:0060426; GO:0060914; GO:0061351; GO:0070613; GO:0072372; GO:0090102; GO:0097541; GO:0097542; GO:0097546; GO:1902017; GO:2000785 0 0 0 PF13174;PF13181; Q61391 CHOYP_MMEL1.2.3 m.12852 sp NEP_MOUSE 39.888 717 416 8 42 749 40 750 0 540 NEP_MOUSE reviewed Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) Mme Mus musculus (Mouse) 750 beta-amyloid metabolic process [GO:0050435]; cellular response to cytokine stimulus [GO:0071345]; cellular response to UV-A [GO:0071492]; cellular response to UV-B [GO:0071493]; creatinine metabolic process [GO:0046449]; kidney development [GO:0001822]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; replicative senescence [GO:0090399]; sensory perception of pain [GO:0019233] GO:0001822; GO:0004175; GO:0004222; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0006508; GO:0006518; GO:0008021; GO:0008233; GO:0008237; GO:0008238; GO:0008270; GO:0016020; GO:0016021; GO:0019233; GO:0030424; GO:0030425; GO:0042277; GO:0044306; GO:0045202; GO:0046449; GO:0050435; GO:0070062; GO:0071345; GO:0071492; GO:0071493; GO:0090399 0 0 cd08662; PF01431;PF05649; Q61391 CHOYP_NEP.1.2 m.26439 sp NEP_MOUSE 43.025 767 407 9 9 765 4 750 0 639 NEP_MOUSE reviewed Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) Mme Mus musculus (Mouse) 750 beta-amyloid metabolic process [GO:0050435]; cellular response to cytokine stimulus [GO:0071345]; cellular response to UV-A [GO:0071492]; cellular response to UV-B [GO:0071493]; creatinine metabolic process [GO:0046449]; kidney development [GO:0001822]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; replicative senescence [GO:0090399]; sensory perception of pain [GO:0019233] GO:0001822; GO:0004175; GO:0004222; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0006508; GO:0006518; GO:0008021; GO:0008233; GO:0008237; GO:0008238; GO:0008270; GO:0016020; GO:0016021; GO:0019233; GO:0030424; GO:0030425; GO:0042277; GO:0044306; GO:0045202; GO:0046449; GO:0050435; GO:0070062; GO:0071345; GO:0071492; GO:0071493; GO:0090399 0 0 cd08662; PF01431;PF05649; Q61391 CHOYP_NEP.2.2 m.61205 sp NEP_MOUSE 45.573 768 374 14 16 762 6 750 0 650 NEP_MOUSE reviewed Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) Mme Mus musculus (Mouse) 750 beta-amyloid metabolic process [GO:0050435]; cellular response to cytokine stimulus [GO:0071345]; cellular response to UV-A [GO:0071492]; cellular response to UV-B [GO:0071493]; creatinine metabolic process [GO:0046449]; kidney development [GO:0001822]; peptide metabolic process [GO:0006518]; proteolysis [GO:0006508]; replicative senescence [GO:0090399]; sensory perception of pain [GO:0019233] GO:0001822; GO:0004175; GO:0004222; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0006508; GO:0006518; GO:0008021; GO:0008233; GO:0008237; GO:0008238; GO:0008270; GO:0016020; GO:0016021; GO:0019233; GO:0030424; GO:0030425; GO:0042277; GO:0044306; GO:0045202; GO:0046449; GO:0050435; GO:0070062; GO:0071345; GO:0071492; GO:0071493; GO:0090399 0 0 cd08662; PF01431;PF05649; Q61466 CHOYP_SMRD1.1.2 m.1725 sp SMRD1_MOUSE 69.276 511 119 7 14 523 42 515 0 689 SMRD1_MOUSE reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (Protein D15KZ1) (SWI/SNF complex 60 kDa subunit) Smarcd1 Baf60a D15Kz1 Mus musculus (Mouse) 515 cellular response to fatty acid [GO:0071398]; chromatin-mediated maintenance of transcription [GO:0048096]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337] GO:0003682; GO:0006337; GO:0006338; GO:0007399; GO:0016514; GO:0016569; GO:0032947; GO:0048096; GO:0071398; GO:0071564; GO:0071565; GO:0090544 0 0 0 PF02201; Q61466 CHOYP_SMRD1.2.2 m.53418 sp SMRD1_MOUSE 71.026 497 111 6 14 500 42 515 0 693 SMRD1_MOUSE reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (Protein D15KZ1) (SWI/SNF complex 60 kDa subunit) Smarcd1 Baf60a D15Kz1 Mus musculus (Mouse) 515 cellular response to fatty acid [GO:0071398]; chromatin-mediated maintenance of transcription [GO:0048096]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; nervous system development [GO:0007399]; nucleosome disassembly [GO:0006337] GO:0003682; GO:0006337; GO:0006338; GO:0007399; GO:0016514; GO:0016569; GO:0032947; GO:0048096; GO:0071398; GO:0071564; GO:0071565; GO:0090544 0 0 0 PF02201; Q61493 CHOYP_DPOLZ.1.1 m.49299 sp DPOLZ_MOUSE 62.63 768 285 1 1743 2510 2357 3122 0 1087 DPOLZ_MOUSE reviewed DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (Seizure-related protein 4) Rev3l Polz Sez4 Mus musculus (Mouse) 3122 DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276] GO:0000166; GO:0003677; GO:0003887; GO:0005730; GO:0006260; GO:0006281; GO:0008408; GO:0016035; GO:0042276; GO:0046872; GO:0051539 0 0 0 PF00136;PF03104;PF15735;PF14260; Q61496 CHOYP_LOC100370637.2.2 m.62143 sp DDX4_MOUSE 56.736 527 206 6 277 799 194 702 0 583 DDX4_MOUSE reviewed Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Mvh) (Vasa homolog) Ddx4 Vasa Mus musculus (Mouse) 702 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; male meiosis I [GO:0007141]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; regulation of protein localization [GO:0032880]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283]; sperm motility [GO:0030317] GO:0003676; GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0007140; GO:0007141; GO:0007275; GO:0007283; GO:0010501; GO:0030154; GO:0030317; GO:0030529; GO:0031047; GO:0032880; GO:0033391; GO:0034587; GO:0043046; GO:0048471; GO:0071546; GO:0071547 0 0 0 PF00270;PF00271; Q61543 CHOYP_GSLG1.3.3 m.66468 sp GSLG1_MOUSE 43.705 1112 566 16 105 1201 107 1173 0 947 GSLG1_MOUSE reviewed Golgi apparatus protein 1 (E-selectin ligand 1) (ESL-1) (Selel) (Golgi sialoglycoprotein MG-160) Glg1 Esl1 Mg160 Selel Mus musculus (Mouse) 1175 bone morphogenesis [GO:0060349]; negative regulation of protein processing [GO:0010955]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of chondrocyte differentiation [GO:0032330] GO:0000139; GO:0005578; GO:0005794; GO:0005886; GO:0010955; GO:0016020; GO:0016021; GO:0017134; GO:0030512; GO:0032330; GO:0060349; GO:0070062 0 0 0 PF00839; Q61555 CHOYP_LOC100643855.1.1 m.6719 sp FBN2_MOUSE 48.991 1090 506 16 3 1063 716 1784 0 981 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q61656 CHOYP_LOC100376610.2.3 m.19396 sp DDX5_MOUSE 59.615 572 219 5 69 632 2 569 0 688 DDX5_MOUSE reviewed Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box RNA helicase DEAD1) (mDEAD1) (DEAD box protein 5) (RNA helicase p68) Ddx5 Tnz2 Mus musculus (Mouse) 614 "circadian rhythm [GO:0007623]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; mRNA transcription [GO:0009299]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of osteoblast differentiation [GO:0045667]; regulation of skeletal muscle cell differentiation [GO:2001014]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]" GO:0000122; GO:0000381; GO:0001701; GO:0003712; GO:0003713; GO:0003724; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006397; GO:0007623; GO:0008380; GO:0009299; GO:0010501; GO:0016020; GO:0030331; GO:0030529; GO:0033148; GO:0036002; GO:0043517; GO:0044822; GO:0045667; GO:0045893; GO:0045944; GO:0050681; GO:0060765; GO:0070062; GO:0071013; GO:0072332; GO:2001014 0 0 0 PF00270;PF00271;PF08061; Q61656 CHOYP_LOC100376610.3.3 m.19687 sp DDX5_MOUSE 56.765 643 241 10 64 702 2 611 0 705 DDX5_MOUSE reviewed Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box RNA helicase DEAD1) (mDEAD1) (DEAD box protein 5) (RNA helicase p68) Ddx5 Tnz2 Mus musculus (Mouse) 614 "circadian rhythm [GO:0007623]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; mRNA transcription [GO:0009299]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of osteoblast differentiation [GO:0045667]; regulation of skeletal muscle cell differentiation [GO:2001014]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]" GO:0000122; GO:0000381; GO:0001701; GO:0003712; GO:0003713; GO:0003724; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006397; GO:0007623; GO:0008380; GO:0009299; GO:0010501; GO:0016020; GO:0030331; GO:0030529; GO:0033148; GO:0036002; GO:0043517; GO:0044822; GO:0045667; GO:0045893; GO:0045944; GO:0050681; GO:0060765; GO:0070062; GO:0071013; GO:0072332; GO:2001014 0 0 0 PF00270;PF00271;PF08061; Q61699 CHOYP_HS105.1.1 m.44378 sp HS105_MOUSE 58.431 510 202 4 5 506 1 508 0 616 HS105_MOUSE reviewed Heat shock protein 105 kDa (42 degrees C-HSP) (Heat shock 110 kDa protein) (Heat shock-related 100 kDa protein E7I) (HSP-E7I) Hsph1 Hsp105 Hsp110 Kiaa0201 Mus musculus (Mouse) 858 chaperone mediated protein folding requiring cofactor [GO:0051085]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of p38MAPK cascade [GO:1903753]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of NK T cell activation [GO:0051135]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor-mediated endocytosis [GO:0006898]; regulation of microtubule cytoskeleton organization [GO:0070507]; response to unfolded protein [GO:0006986] GO:0005524; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006898; GO:0006986; GO:0043014; GO:0043524; GO:0045345; GO:0045944; GO:0051085; GO:0051135; GO:0061098; GO:0070062; GO:0070507; GO:1903748; GO:1903751; GO:1903753; GO:2001234 0 0 0 PF00012; Q62077 CHOYP_LOC100377901.1.1 m.7173 sp PLCG1_MOUSE 47.364 1271 606 25 6 1234 18 1267 0 1154 PLCG1_MOUSE reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)" Plcg1 Plcg-1 Mus musculus (Mouse) 1302 calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; in utero embryonic development [GO:0001701]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852] GO:0001701; GO:0001726; GO:0002223; GO:0004435; GO:0004871; GO:0005168; GO:0005509; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0007173; GO:0008180; GO:0009395; GO:0010634; GO:0016477; GO:0019722; GO:0019901; GO:0030027; GO:0030971; GO:0035254; GO:0042995; GO:0043536; GO:0045766; GO:0050852; GO:0051281; GO:0071364 0 0 0 PF00168;PF00388;PF00387;PF00017;PF00018; Q62130 CHOYP_PTPN14.1.1 m.65714 sp PTN14_MOUSE 34.343 1255 682 34 1 1179 1 1189 0 621 PTN14_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36) Ptpn14 Mus musculus (Mouse) 1189 "lymphangiogenesis [GO:0001946]; negative regulation of cell proliferation [GO:0008285]; regulation of protein export from nucleus [GO:0046825]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001946; GO:0003712; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005856; GO:0006351; GO:0006355; GO:0008285; GO:0030971; GO:0046825 0 0 0 PF09380;PF00373;PF09379;PF00102; Q62371 CHOYP_BRAFLDRAFT_225535.1.1 m.38542 sp DDR2_MOUSE 40.456 922 446 20 38 956 30 851 0 625 DDR2_MOUSE reviewed "Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)" Ddr2 Ntrkr3 Tkt Tyro10 Mus musculus (Mouse) 854 biomineral tissue development [GO:0031214]; chondrocyte proliferation [GO:0035988]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; collagen fibril organization [GO:0030199]; endochondral bone growth [GO:0003416]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell proliferation [GO:0008284]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001503; GO:0003416; GO:0004714; GO:0005518; GO:0005524; GO:0005887; GO:0005925; GO:0007169; GO:0008284; GO:0010763; GO:0018108; GO:0030199; GO:0030500; GO:0031214; GO:0035988; GO:0038062; GO:0038063; GO:0045669; GO:0045860; GO:0046777; GO:0048146; GO:0051091; GO:0070062; GO:0090091 0 0 0 PF00754;PF07714; Q62371 CHOYP_LOC100903889.1.1 m.55297 sp DDR2_MOUSE 41.341 895 448 20 38 927 30 852 0 627 DDR2_MOUSE reviewed "Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)" Ddr2 Ntrkr3 Tkt Tyro10 Mus musculus (Mouse) 854 biomineral tissue development [GO:0031214]; chondrocyte proliferation [GO:0035988]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; collagen fibril organization [GO:0030199]; endochondral bone growth [GO:0003416]; ossification [GO:0001503]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell proliferation [GO:0008284]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein autophosphorylation [GO:0046777]; regulation of bone mineralization [GO:0030500]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001503; GO:0003416; GO:0004714; GO:0005518; GO:0005524; GO:0005887; GO:0005925; GO:0007169; GO:0008284; GO:0010763; GO:0018108; GO:0030199; GO:0030500; GO:0031214; GO:0035988; GO:0038062; GO:0038063; GO:0045669; GO:0045860; GO:0046777; GO:0048146; GO:0051091; GO:0070062; GO:0090091 0 0 0 PF00754;PF07714; Q62388 CHOYP_LOC100369761.1.1 m.56836 sp ATM_MOUSE 40.649 1663 880 34 1 1598 1446 3066 0 1205 ATM_MOUSE reviewed Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T mutated homolog) Atm Mus musculus (Mouse) 3066 "brain development [GO:0007420]; cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to nitrosative stress [GO:0071500]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint [GO:0000077]; DNA damage induced protein phosphorylation [GO:0006975]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; establishment of RNA localization to telomere [GO:0097694]; female gamete generation [GO:0007292]; heart development [GO:0007507]; histone mRNA catabolic process [GO:0071044]; histone phosphorylation [GO:0016572]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipoprotein catabolic process [GO:0042159]; meiotic telomere clustering [GO:0045141]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of telomere capping [GO:1904354]; negative regulation of TORC1 signaling [GO:1904262]; neuron apoptotic process [GO:0051402]; oocyte development [GO:0048599]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of histone phosphorylation [GO:0033129]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; pre-B cell allelic exclusion [GO:0002331]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; replicative senescence [GO:0090399]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; signal transduction involved in mitotic G2 DNA damage checkpoint [GO:0072434]; somitogenesis [GO:0001756]; telomere maintenance via telomerase [GO:0007004]; V(D)J recombination [GO:0033151]" GO:0000077; GO:0000724; GO:0000781; GO:0001666; GO:0001756; GO:0002331; GO:0003677; GO:0004672; GO:0004674; GO:0004677; GO:0005524; GO:0005634; GO:0005654; GO:0005819; GO:0006281; GO:0006468; GO:0006974; GO:0006975; GO:0007004; GO:0007050; GO:0007094; GO:0007292; GO:0007420; GO:0007507; GO:0008340; GO:0008630; GO:0010212; GO:0010506; GO:0016023; GO:0016301; GO:0016303; GO:0016572; GO:0018105; GO:0030889; GO:0032212; GO:0032403; GO:0033129; GO:0033151; GO:0036289; GO:0042159; GO:0043065; GO:0043517; GO:0043525; GO:0045141; GO:0046777; GO:0046983; GO:0047485; GO:0048599; GO:0051402; GO:0071044; GO:0071480; GO:0071500; GO:0072434; GO:0090399; GO:0097694; GO:1904262; GO:1904354; GO:1904358; GO:1904884; GO:1990391 0 0 0 PF02259;PF02260;PF00454;PF11640; Q62441 CHOYP_TLE4.1.1 m.19069 sp TLE4_MOUSE 69.171 772 195 18 1 735 8 773 0 981 TLE4_MOUSE reviewed Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) Tle4 Grg4 Mus musculus (Mouse) 773 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0000122; GO:0003682; GO:0003705; GO:0003714; GO:0005634; GO:0006351; GO:0016055; GO:0045892; GO:0070491 0 0 0 PF03920;PF00400; Q62448 CHOYP_IF4G2.1.1 m.62766 sp IF4G2_MOUSE 46.832 805 363 16 1 782 131 893 0 669 IF4G2_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Novel APOBEC-1 target 1) (Translation repressor NAT1) (p97) Eif4g2 Nat1 Mus musculus (Mouse) 906 regulation of translational initiation [GO:0006446] GO:0003743; GO:0005737; GO:0006446; GO:0008135; GO:0016020; GO:0016281; GO:0044822 0 0 0 PF02847;PF02854;PF02020; Q62717 CHOYP_LOC100372028.1.1 m.22341 sp CAPS1_RAT 67.085 1194 342 10 76 1249 107 1269 0 1670 CAPS1_RAT reviewed Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1) (rCAPS) Cadps Caps Caps1 Rattus norvegicus (Rat) 1289 dense core granule exocytosis [GO:1990504]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; protein transport [GO:0015031]; regulated exocytosis [GO:0045055]; synaptic vesicle exocytosis [GO:0016079] GO:0005509; GO:0005546; GO:0015031; GO:0016079; GO:0030054; GO:0030659; GO:0045055; GO:0045956; GO:0098793; GO:1990504 0 0 0 PF06292;PF00169; Q62762 CHOYP_KC1G3.1.2 m.18974 sp KC1G2_RAT 68.258 419 120 5 3 421 10 415 0 586 KC1G2_RAT reviewed Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1) Csnk1g2 Ck1g2 Rattus norvegicus (Rat) 415 endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; Wnt signaling pathway [GO:0016055] GO:0000287; GO:0001948; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0006897; GO:0008360; GO:0016020; GO:0016055; GO:0018105; GO:0042277; GO:0046777; GO:0051219 0 0 0 PF12605;PF00069; Q62824 CHOYP_EXOC4.1.2 m.4421 sp EXOC4_RAT 43.375 966 497 18 20 947 4 957 0 748 EXOC4_RAT reviewed Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) Exoc4 Sec8 Sec8l1 Rattus norvegicus (Rat) 975 chemical synaptic transmission [GO:0007268]; establishment of cell polarity [GO:0030010]; Golgi to transport vesicle transport [GO:0055108]; membrane biogenesis [GO:0044091]; oligodendrocyte differentiation [GO:0048709]; positive regulation of calcium-mediated signaling [GO:0050850]; protein targeting to membrane [GO:0006612]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle targeting [GO:0006903] GO:0000145; GO:0006612; GO:0006903; GO:0006904; GO:0007268; GO:0014069; GO:0030010; GO:0030165; GO:0030426; GO:0032403; GO:0043005; GO:0043025; GO:0043198; GO:0043209; GO:0043234; GO:0044091; GO:0045202; GO:0048709; GO:0050850; GO:0051223; GO:0055108 0 0 0 PF04048; Q62824 CHOYP_EXOC4.2.2 m.39754 sp EXOC4_RAT 42.467 989 496 19 22 972 4 957 0 740 EXOC4_RAT reviewed Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) Exoc4 Sec8 Sec8l1 Rattus norvegicus (Rat) 975 chemical synaptic transmission [GO:0007268]; establishment of cell polarity [GO:0030010]; Golgi to transport vesicle transport [GO:0055108]; membrane biogenesis [GO:0044091]; oligodendrocyte differentiation [GO:0048709]; positive regulation of calcium-mediated signaling [GO:0050850]; protein targeting to membrane [GO:0006612]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle targeting [GO:0006903] GO:0000145; GO:0006612; GO:0006903; GO:0006904; GO:0007268; GO:0014069; GO:0030010; GO:0030165; GO:0030426; GO:0032403; GO:0043005; GO:0043025; GO:0043198; GO:0043209; GO:0043234; GO:0044091; GO:0045202; GO:0048709; GO:0050850; GO:0051223; GO:0055108 0 0 0 PF04048; Q62829 CHOYP_LOC100160077.1.1 m.62645 sp PAK3_RAT 62.186 558 149 6 1 514 1 540 0 682 PAK3_RAT reviewed Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (p21-activated kinase 3) (PAK-3) (p65-PAK) Pak3 Rattus norvegicus (Rat) 544 axonogenesis [GO:0007409]; cellular response to organic cyclic compound [GO:0071407]; dendrite development [GO:0016358]; dendritic spine development [GO:0060996]; intracellular signal transduction [GO:0035556]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of neuron apoptotic process [GO:0043525]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of neuron projection development [GO:0010975] GO:0004672; GO:0004674; GO:0004702; GO:0004708; GO:0005524; GO:0005768; GO:0006468; GO:0007409; GO:0010763; GO:0010975; GO:0016358; GO:0030833; GO:0032956; GO:0035556; GO:0043525; GO:0046872; GO:0051020; GO:0060996; GO:0061003; GO:0071407; GO:2000573 0 0 0 PF00786;PF00069; Q62940 CHOYP_NED4L.1.1 m.7792 sp NEDD4_RAT 50.899 890 303 15 20 851 74 887 0 829 NEDD4_RAT reviewed E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) Nedd4 Nedd4a Rattus norvegicus (Rat) 887 immune response [GO:0006955]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of dendrite morphogenesis [GO:0048814]; response to denervation involved in regulation of muscle adaptation [GO:0014894] GO:0004842; GO:0005634; GO:0005737; GO:0005886; GO:0005902; GO:0006955; GO:0008022; GO:0014894; GO:0016567; GO:0016874; GO:0030948; GO:0042787; GO:0045121; GO:0048814; GO:0070534 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00168;PF00632;PF00397; Q63041 CHOYP_A2M.1.3 m.44287 sp A1M_RAT 32.318 1445 821 37 141 1513 128 1487 0 721 A1M_RAT reviewed Alpha-1-macroglobulin (Alpha-1-M) (Alpha-1-macroglobulin 165 kDa subunit) [Cleaved into: Alpha-1-macroglobulin 45 kDa subunit] A1m Pzp Rattus norvegicus (Rat) 1500 embryo implantation [GO:0007566] GO:0004867; GO:0005615; GO:0007566; GO:0032403; GO:0048403; GO:0048406 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q63164 CHOYP_DYH1.1.1 m.46156 sp DYH1_RAT 63.916 4096 1312 17 234 4214 472 4516 0 5455 DYH1_RAT reviewed "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1)" Dnah1 Dlp1 Rattus norvegicus (Rat) 4516 cilium movement involved in cell motility [GO:0060294]; epithelial cilium movement [GO:0003351]; inner dynein arm assembly [GO:0036159]; sperm motility [GO:0030317] GO:0003351; GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0016887; GO:0030317; GO:0036126; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q63164 CHOYP_LOC100370750.2.2 m.52391 sp DYH1_RAT 34.969 2405 1194 41 2566 4922 2433 4515 0 1390 DYH1_RAT reviewed "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1)" Dnah1 Dlp1 Rattus norvegicus (Rat) 4516 cilium movement involved in cell motility [GO:0060294]; epithelial cilium movement [GO:0003351]; inner dynein arm assembly [GO:0036159]; sperm motility [GO:0030317] GO:0003351; GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0016887; GO:0030317; GO:0036126; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q63164 CHOYP_TRIADDRAFT_56463.2.2 m.36123 sp DYH1_RAT 22.222 3429 1964 106 682 3945 1582 4472 0 658 DYH1_RAT reviewed "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1)" Dnah1 Dlp1 Rattus norvegicus (Rat) 4516 cilium movement involved in cell motility [GO:0060294]; epithelial cilium movement [GO:0003351]; inner dynein arm assembly [GO:0036159]; sperm motility [GO:0030317] GO:0003351; GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0016887; GO:0030317; GO:0036126; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q63170 CHOYP_DNAH12.2.3 m.32353 sp DYH7_RAT 54.368 3949 1706 23 103 4013 167 4057 0 4364 DYH7_RAT reviewed "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) 4057 cilium movement [GO:0003341] GO:0003341; GO:0003777; GO:0005509; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0016887 0 0 0 PF12780;PF08393;PF03028;PF12777; Q63170 CHOYP_DNAH12.3.3 m.63246 sp DYH7_RAT 60.408 2546 983 11 473 3001 1520 4057 0 3224 DYH7_RAT reviewed "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) 4057 cilium movement [GO:0003341] GO:0003341; GO:0003777; GO:0005509; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0016887 0 0 0 PF12780;PF08393;PF03028;PF12777; Q63406 CHOYP_MCF2L.1.1 m.54928 sp MCF2L_RAT 35.365 1083 637 22 7 1063 66 1111 0 681 MCF2L_RAT reviewed Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2-transforming sequence-like protein) (OST oncogene) Mcf2l Ost Rattus norvegicus (Rat) 1149 intracellular signal transduction [GO:0035556]; positive regulation of Rho protein signal transduction [GO:0035025] GO:0005089; GO:0005737; GO:0005886; GO:0008289; GO:0019898; GO:0035025; GO:0035556 0 0 0 PF13716;PF00169;PF00621;PF00435; Q63421 CHOYP_LOC100376069.1.5 m.1787 sp PDE1C_RAT 47.724 681 273 10 25 667 11 646 0 607 PDE1C_RAT reviewed "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Rattus norvegicus (Rat) 768 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of insulin secretion [GO:0046676]; response to calcium ion [GO:0051592]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] GO:0004115; GO:0004117; GO:0006198; GO:0007165; GO:0007608; GO:0030552; GO:0043025; GO:0046069; GO:0046676; GO:0046872; GO:0048101; GO:0051592 0 0 0 PF00233;PF08499; Q63421 CHOYP_LOC100376069.3.5 m.50559 sp PDE1C_RAT 47.504 661 266 9 47 669 5 622 0 584 PDE1C_RAT reviewed "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Rattus norvegicus (Rat) 768 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of insulin secretion [GO:0046676]; response to calcium ion [GO:0051592]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] GO:0004115; GO:0004117; GO:0006198; GO:0007165; GO:0007608; GO:0030552; GO:0043025; GO:0046069; GO:0046676; GO:0046872; GO:0048101; GO:0051592 0 0 0 PF00233;PF08499; Q63421 CHOYP_LOC100376069.4.5 m.62737 sp PDE1C_RAT 50.169 592 234 6 162 723 86 646 0 582 PDE1C_RAT reviewed "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Rattus norvegicus (Rat) 768 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of insulin secretion [GO:0046676]; response to calcium ion [GO:0051592]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] GO:0004115; GO:0004117; GO:0006198; GO:0007165; GO:0007608; GO:0030552; GO:0043025; GO:0046069; GO:0046676; GO:0046872; GO:0048101; GO:0051592 0 0 0 PF00233;PF08499; Q63421 CHOYP_LOC100376069.5.5 m.65931 sp PDE1C_RAT 52.281 570 233 5 162 701 86 646 0 597 PDE1C_RAT reviewed "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Rattus norvegicus (Rat) 768 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of insulin secretion [GO:0046676]; response to calcium ion [GO:0051592]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] GO:0004115; GO:0004117; GO:0006198; GO:0007165; GO:0007608; GO:0030552; GO:0043025; GO:0046069; GO:0046676; GO:0046872; GO:0048101; GO:0051592 0 0 0 PF00233;PF08499; Q63470 CHOYP_MNB.1.1 m.14023 sp DYR1A_RAT 78.049 492 87 7 75 555 72 553 0 751 DYR1A_RAT reviewed Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.2) (Dual specificity YAK1-related kinase) (Protein kinase minibrain homolog) (MNBH) (RP86) Dyrk1a Dyrk Rattus norvegicus (Rat) 763 "circadian rhythm [GO:0007623]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of protein deacetylation [GO:0090312]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000381; GO:0004672; GO:0004674; GO:0004712; GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0006468; GO:0007623; GO:0016607; GO:0018105; GO:0018107; GO:0018108; GO:0030529; GO:0043518; GO:0043621; GO:0046777; GO:0048025; GO:0090312 0 0 0 PF00069; Q63486 CHOYP_RRAGA.1.1 m.41224 sp RRAGA_RAT 87.987 308 37 0 8 315 6 313 0 572 RRAGA_RAT reviewed Ras-related GTP-binding protein A (Rag A) (RagA) Rraga Rattus norvegicus (Rat) 313 apoptotic process [GO:0006915]; cell death [GO:0008219]; cellular protein localization [GO:0034613]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to starvation [GO:0009267]; modulation by virus of host morphology or physiology [GO:0019048]; negative regulation of autophagy [GO:0010507]; positive regulation of cytolysis [GO:0045919]; positive regulation of TORC1 signaling [GO:1904263]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432]; response to amino acid [GO:0043200] GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006915; GO:0008219; GO:0009267; GO:0010506; GO:0010507; GO:0019048; GO:0032008; GO:0034198; GO:0034448; GO:0034613; GO:0042803; GO:0043200; GO:0045919; GO:0046982; GO:0051219; GO:0071230; GO:1903432; GO:1904263; GO:1990130; GO:1990131 0 0 0 PF04670; Q63569 CHOYP_LOC100376932.1.1 m.12642 sp PRS6A_RAT 85.748 421 58 2 24 443 20 439 0 751 PRS6A_RAT reviewed 26S protease regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) Psmc3 Tbp1 Rattus norvegicus (Rat) 439 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899] GO:0000932; GO:0005524; GO:0005737; GO:0008540; GO:0017025; GO:0022624; GO:0030433; GO:0031595; GO:0031597; GO:0036402; GO:0045899; GO:0048471 0 0 0 PF00004; Q63598 CHOYP_LOC100166368.1.1 m.44709 sp PLST_RAT 52.126 635 281 11 229 846 1 629 0 644 PLST_RAT reviewed Plastin-3 (T-plastin) Pls3 Rattus norvegicus (Rat) 630 auditory receptor cell differentiation [GO:0042491] GO:0005509; GO:0005737; GO:0032420; GO:0042491 0 0 0 PF00307;PF13499; Q63598 CHOYP_PHUM_PHUM267720.2.2 m.57552 sp PLST_RAT 56.996 486 190 9 179 650 149 629 0 541 PLST_RAT reviewed Plastin-3 (T-plastin) Pls3 Rattus norvegicus (Rat) 630 auditory receptor cell differentiation [GO:0042491] GO:0005509; GO:0005737; GO:0032420; GO:0042491 0 0 0 PF00307;PF13499; Q63615 CHOYP_VP33A.1.1 m.58311 sp VP33A_RAT 63.1 542 186 5 1 537 63 595 0 707 VP33A_RAT reviewed Vacuolar protein sorting-associated protein 33A (r-vps33a) Vps33a Rattus norvegicus (Rat) 597 protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904] GO:0005765; GO:0005769; GO:0005776; GO:0006904; GO:0015031; GO:0030136; GO:0031410; GO:0031902; GO:0032403 0 0 0 PF00995; Q63632 CHOYP_S12A4.1.1 m.41348 sp S12A4_RAT 58.736 538 196 7 1 534 570 1085 0 664 S12A4_RAT reviewed Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (rKCC1) (Furosemide-sensitive K-Cl cotransporter) Slc12a4 Kcc1 Rattus norvegicus (Rat) 1085 chemical synaptic transmission [GO:0007268] GO:0005765; GO:0007268; GO:0015379; GO:0016021; GO:0022820 0 0 0 PF00324;PF03522; Q63HN8 CHOYP_LOC100056407.1.1 m.53871 sp RN213_HUMAN 43.524 1243 636 24 1165 2389 1793 2987 0 947 RN213_HUMAN reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) 5207 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:21799892}. 0 0 PF00097; Q640I9 CHOYP_KDM2B.1.1 m.58688 sp KDM2B_XENLA 38.63 1328 681 34 1 1285 1 1237 0 831 KDM2B_XENLA reviewed Lysine-specific demethylase 2B (EC 1.14.11.27) (F-box and leucine-rich repeat protein 10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) ([Histone-H3]-lysine-36 demethylase 1B) kdm2b fbxl10 jhdm1b Xenopus laevis (African clawed frog) 1259 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005730; GO:0006351; GO:0006355; GO:0008270; GO:0019843; GO:0051864 0 0 0 PF00646;PF02373;PF16866;PF02008; Q640L2 CHOYP_SPX3.1.1 m.34834 sp SPX3_XENLA 55.361 513 198 6 5 517 18 499 0 566 SPX3_XENLA reviewed Sugar phosphate exchanger 3 (Solute carrier family 37 member 3) slc37a3 spx3 Xenopus laevis (African clawed frog) 503 carbohydrate transport [GO:0008643]; transmembrane transport [GO:0055085] GO:0005215; GO:0008643; GO:0030176; GO:0055085 0 0 cd06174; PF07690; Q640Q5 CHOYP_LOC100370269.1.1 m.55713 sp PAN3_MOUSE 54.009 661 241 16 147 791 216 829 0 655 PAN3_MOUSE reviewed PAB-dependent poly(A)-specific ribonuclease subunit PAN3 (PAB1P-dependent poly(A)-nuclease) (PAN deadenylation complex subunit 3) Pan3 Mus musculus (Mouse) 837 deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; protein targeting [GO:0006605] GO:0000289; GO:0000290; GO:0000932; GO:0004535; GO:0004672; GO:0005524; GO:0006397; GO:0006605; GO:0010606; GO:0031251; GO:0044822; GO:0046872 0 0 0 0 Q641G3 CHOYP_CCAR1.1.1 m.25430 sp CCAR1_XENLA 46.08 829 373 11 305 1099 369 1157 0 666 CCAR1_XENLA reviewed Cell division cycle and apoptosis regulator protein 1 ccar1 Xenopus laevis (African clawed frog) 1157 "cell cycle [GO:0007049]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]" GO:0006355; GO:0006417; GO:0007049; GO:0048471 0 0 0 PF14443;PF14444;PF02037; Q641W4 CHOYP_RFC2.1.2 m.12863 sp RFC2_RAT 79.819 332 65 1 18 349 17 346 0 576 RFC2_RAT reviewed Replication factor C subunit 2 (Activator 1 subunit C2) Rfc2 Rattus norvegicus (Rat) 349 DNA-dependent DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] GO:0003677; GO:0005524; GO:0005634; GO:0005663; GO:0006261; GO:0031390; GO:1900264 0 0 0 PF00004;PF08542; Q641W4 CHOYP_RFC2.2.2 m.18092 sp RFC2_RAT 79.819 332 65 1 20 351 17 346 0 576 RFC2_RAT reviewed Replication factor C subunit 2 (Activator 1 subunit C2) Rfc2 Rattus norvegicus (Rat) 349 DNA-dependent DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] GO:0003677; GO:0005524; GO:0005634; GO:0005663; GO:0006261; GO:0031390; GO:1900264 0 0 0 PF00004;PF08542; Q641W7 CHOYP_LOC100634892.1.2 m.6791 sp TTLL9_RAT 61.22 410 132 3 130 514 52 459 0 540 TTLL9_RAT reviewed Probable tubulin polyglutamylase TTLL9 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 9) Ttll9 Rattus norvegicus (Rat) 461 cellular protein modification process [GO:0006464] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0006464; GO:0016874 0 0 0 PF03133; Q641W7 CHOYP_LOC100634892.2.2 m.17949 sp TTLL9_RAT 61.22 410 132 3 130 514 52 459 0 540 TTLL9_RAT reviewed Probable tubulin polyglutamylase TTLL9 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 9) Ttll9 Rattus norvegicus (Rat) 461 cellular protein modification process [GO:0006464] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0006464; GO:0016874 0 0 0 PF03133; Q641W7 CHOYP_LOC583590.1.1 m.49387 sp TTLL9_RAT 53.937 508 155 6 2 484 6 459 0 553 TTLL9_RAT reviewed Probable tubulin polyglutamylase TTLL9 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 9) Ttll9 Rattus norvegicus (Rat) 461 cellular protein modification process [GO:0006464] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0006464; GO:0016874 0 0 0 PF03133; Q641X8 CHOYP_EIF3E.1.1 m.27167 sp EIF3E_RAT 77.324 441 96 3 22 459 1 440 0 717 EIF3E_RAT reviewed Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (eIF-3 p48) Eif3e Eif3s6 Int6 Rattus norvegicus (Rat) 445 "formation of translation preinitiation complex [GO:0001731]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]" GO:0000184; GO:0001731; GO:0003743; GO:0005634; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0016605; GO:0033290 0 0 0 PF09440;PF01399; Q641Y2 CHOYP_LOC732900.1.1 m.62814 sp NDUS2_RAT 74.596 433 106 2 50 480 33 463 0 694 NDUS2_RAT reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)" Ndufs2 Rattus norvegicus (Rat) 463 response to oxidative stress [GO:0006979] GO:0005654; GO:0005747; GO:0006979; GO:0008137; GO:0046872; GO:0048038; GO:0051287; GO:0051539 0 0 0 PF00346; Q641Z4 CHOYP_CDK9.1.1 m.16695 sp CDK9_RAT 74.387 367 91 1 48 411 6 372 0 578 CDK9_RAT reviewed Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 9) Cdk9 Rattus norvegicus (Rat) 372 "cellular response to cytokine stimulus [GO:0071345]; DNA repair [GO:0006281]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of mRNA polyadenylation [GO:1900364]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of histone H2B ubiquitination [GO:2001168]; positive regulation of histone phosphorylation [GO:0033129]; positive regulation of mRNA 3'-UTR binding [GO:1903839]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of DNA repair [GO:0006282]; replication fork processing [GO:0031297]; response to drug [GO:0042493]; transcription, DNA-templated [GO:0006351]" GO:0000979; GO:0003682; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0006281; GO:0006282; GO:0006351; GO:0008023; GO:0008024; GO:0008134; GO:0008353; GO:0010613; GO:0016020; GO:0016605; GO:0031297; GO:0033129; GO:0042493; GO:0045944; GO:0071157; GO:0071345; GO:0097322; GO:1900364; GO:1903839; GO:2001168 0 0 0 PF00069; Q641Z6 CHOYP_LOC100875390.1.1 m.24780 sp EHD1_RAT 70.093 535 159 1 1 535 1 534 0 788 EHD1_RAT reviewed EH domain-containing protein 1 Ehd1 Rattus norvegicus (Rat) 534 cellular response to nerve growth factor stimulus [GO:1990090]; cholesterol homeostasis [GO:0042632]; cilium assembly [GO:0042384]; endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; low-density lipoprotein particle clearance [GO:0034383]; neuron projection development [GO:0031175]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of myoblast fusion [GO:1901741]; protein localization to cilium [GO:0061512] GO:0005509; GO:0005524; GO:0005525; GO:0005811; GO:0005886; GO:0006886; GO:0006897; GO:0010008; GO:0010886; GO:0020018; GO:0030139; GO:0031095; GO:0031175; GO:0031901; GO:0032456; GO:0034383; GO:0042384; GO:0042632; GO:0043209; GO:0048471; GO:0055038; GO:0061512; GO:1901741; GO:1990090; GO:2001137 0 0 0 PF00350;PF12763;PF16880; Q642R9 CHOYP_RB3GP.1.2 m.53902 sp RB3GP_XENLA 47.204 1091 441 22 5 1074 1 977 0 965 RB3GP_XENLA reviewed Rab3 GTPase-activating protein catalytic subunit rab3gap1 rab3gap Xenopus laevis (African clawed frog) 978 0 GO:0005096; GO:0005737 0 0 0 PF13890; Q642T7 CHOYP_DIEXF.1.1 m.16330 sp DIEXF_XENTR 44.256 766 368 14 28 750 16 765 0 629 DIEXF_XENTR reviewed Digestive organ expansion factor homolog diexf def Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 765 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; multicellular organism development [GO:0007275]" GO:0000462; GO:0005730; GO:0007275; GO:0019843; GO:0032040; GO:0034511 0 0 0 PF06862; Q64487 CHOYP_PTPRF.5.6 m.43288 sp PTPRD_MOUSE 44.699 1877 850 53 37 1826 137 1912 0 1367 PTPRD_MOUSE reviewed Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) Ptprd Mus musculus (Mouse) 1912 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of JAK-STAT cascade [GO:0046426]; neuron differentiation [GO:0030182]; positive regulation of dendrite morphogenesis [GO:0050775]; presynaptic membrane assembly [GO:0097105]; regulation of immune response [GO:0050776] GO:0004725; GO:0005102; GO:0007157; GO:0016021; GO:0030182; GO:0046426; GO:0050775; GO:0050776; GO:0050839; GO:0097105 0 0 0 PF00041;PF07679;PF00102; Q64511 CHOYP_TOP2B.1.1 m.6674 sp TOP2B_MOUSE 57.948 1667 580 28 86 1727 35 1605 0 1832 TOP2B_MOUSE reviewed "DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)" Top2b Mus musculus (Mouse) 1612 axonogenesis [GO:0007409]; DNA topological change [GO:0006265]; DNA unwinding involved in DNA replication [GO:0006268]; forebrain development [GO:0030900]; mitotic DNA integrity checkpoint [GO:0044774]; mitotic recombination [GO:0006312]; neuron migration [GO:0001764]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819] GO:0000712; GO:0000819; GO:0001764; GO:0003682; GO:0003918; GO:0005080; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006265; GO:0006268; GO:0006312; GO:0007409; GO:0008022; GO:0008301; GO:0009330; GO:0019899; GO:0030900; GO:0042826; GO:0044774; GO:0046872; GO:0046982 0 0 0 PF00204;PF00521;PF08070;PF02518;PF01751;PF16898; Q64620 CHOYP_PPP6.1.1 m.16278 sp PPP6_RAT 85.382 301 44 0 31 331 5 305 0 564 PPP6_RAT reviewed "Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) (Protein phosphatase V) (PP-V) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]" Ppp6c Ppv Rattus norvegicus (Rat) 305 cell cycle [GO:0007049]; protein dephosphorylation [GO:0006470] GO:0004722; GO:0005829; GO:0006470; GO:0007049; GO:0046872 0 0 0 PF00149; Q64729 CHOYP_BABO.1.1 m.51666 sp TGFR1_MOUSE 58.285 513 188 11 6 514 13 503 0 584 TGFR1_MOUSE reviewed TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I) Tgfbr1 Mus musculus (Mouse) 503 "activation of MAPKK activity [GO:0000186]; activin receptor signaling pathway [GO:0032924]; angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; artery morphogenesis [GO:0048844]; blastocyst development [GO:0001824]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell motility [GO:0048870]; cellular response to transforming growth factor beta stimulus [GO:0071560]; collagen fibril organization [GO:0030199]; coronary artery morphogenesis [GO:0060982]; embryonic cranial skeleton morphogenesis [GO:0048701]; endothelial cell activation [GO:0042118]; endothelial cell migration [GO:0043542]; epithelial to mesenchymal transition [GO:0001837]; germ cell migration [GO:0008354]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; male gonad development [GO:0008584]; mesenchymal cell differentiation [GO:0048762]; negative regulation of apoptotic process [GO:0043066]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron fate commitment [GO:0048663]; palate development [GO:0060021]; parathyroid gland development [GO:0060017]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; pharyngeal system development [GO:0060037]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cellular component movement [GO:0051272]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of gene expression [GO:0010628]; positive regulation of occluding junction disassembly [GO:1905075]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of SMAD protein import into nucleus [GO:0060391]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription, DNA-templated [GO:0045893]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of cardiac muscle cell proliferation [GO:0060043]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of protein binding [GO:0043393]; regulation of protein ubiquitination [GO:0031396]; regulation of transcription, DNA-templated [GO:0006355]; response to cholesterol [GO:0070723]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; thymus development [GO:0048538]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular compact myocardium morphogenesis [GO:0003223]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000186; GO:0001501; GO:0001525; GO:0001701; GO:0001822; GO:0001824; GO:0001837; GO:0001937; GO:0001938; GO:0002088; GO:0003222; GO:0003223; GO:0004672; GO:0004674; GO:0004702; GO:0005024; GO:0005025; GO:0005057; GO:0005102; GO:0005114; GO:0005524; GO:0005622; GO:0005623; GO:0005768; GO:0005886; GO:0005901; GO:0005923; GO:0006355; GO:0006468; GO:0006915; GO:0007165; GO:0007179; GO:0007507; GO:0008284; GO:0008354; GO:0008584; GO:0009791; GO:0009952; GO:0009986; GO:0010468; GO:0010628; GO:0010717; GO:0010718; GO:0010862; GO:0016020; GO:0016021; GO:0018105; GO:0018107; GO:0030199; GO:0030307; GO:0030335; GO:0031396; GO:0032331; GO:0032924; GO:0035556; GO:0042118; GO:0043066; GO:0043235; GO:0043393; GO:0043542; GO:0045121; GO:0045893; GO:0046332; GO:0046872; GO:0048538; GO:0048663; GO:0048701; GO:0048705; GO:0048762; GO:0048844; GO:0048870; GO:0050431; GO:0051272; GO:0051491; GO:0051496; GO:0051897; GO:0060017; GO:0060021; GO:0060037; GO:0060043; GO:0060317; GO:0060389; GO:0060391; GO:0060412; GO:0060982; GO:0070411; GO:0070723; GO:0071560; GO:1905007; GO:1905075; GO:2001235; GO:2001237 0 0 0 PF01064;PF00069;PF08515; Q64737 CHOYP_PUR2.1.1 m.17810 sp PUR2_MOUSE 57.353 1020 409 7 2 1009 3 1008 0 1149 PUR2_MOUSE reviewed Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)] Gart Mus musculus (Mouse) 1010 'de novo' IMP biosynthetic process [GO:0006189]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; glycine metabolic process [GO:0006544]; purine nucleobase biosynthetic process [GO:0009113]; response to inorganic substance [GO:0010035]; response to organic substance [GO:0010033]; tetrahydrofolate biosynthetic process [GO:0046654] GO:0003360; GO:0004637; GO:0004641; GO:0004644; GO:0005524; GO:0005737; GO:0006189; GO:0006544; GO:0009113; GO:0010033; GO:0010035; GO:0021549; GO:0021987; GO:0046654; GO:0046872; GO:0070062 PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1. 0 cd08645;cd02196; PF00586;PF02769;PF00551;PF01071;PF02843;PF02844; Q659X0 CHOYP_FUT8.1.1 m.9231 sp FUT8_CANLF 52.357 594 255 5 3 593 7 575 0 655 FUT8_CANLF reviewed "Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)" FUT8 Canis lupus familiaris (Dog) (Canis familiaris) 575 GDP-L-fucose metabolic process [GO:0046368]; N-glycan fucosylation [GO:0036071]; protein glycosylation in Golgi [GO:0033578]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] GO:0006487; GO:0008424; GO:0016021; GO:0018279; GO:0032580; GO:0033578; GO:0036071; GO:0046368; GO:0046921 PATHWAY: Protein modification; protein glycosylation. 0 0 PF14604; Q66HD0 CHOYP_ENPL.1.4 m.1125 sp ENPL_RAT 68.074 758 230 7 6 758 5 755 0 1013 ENPL_RAT reviewed Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) Hsp90b1 Grp94 Tra1 Rattus norvegicus (Rat) 804 cellular response to manganese ion [GO:0071287]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein folding [GO:0006457] GO:0005524; GO:0005788; GO:0005790; GO:0006457; GO:0030433; GO:0042470; GO:0071287 0 0 0 PF02518;PF00183; Q66HD0 CHOYP_ENPL.2.4 m.6441 sp ENPL_RAT 68.678 696 209 5 1 693 66 755 0 942 ENPL_RAT reviewed Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) Hsp90b1 Grp94 Tra1 Rattus norvegicus (Rat) 804 cellular response to manganese ion [GO:0071287]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein folding [GO:0006457] GO:0005524; GO:0005788; GO:0005790; GO:0006457; GO:0030433; GO:0042470; GO:0071287 0 0 0 PF02518;PF00183; Q66HD0 CHOYP_ENPL.3.4 m.39476 sp ENPL_RAT 68.338 758 228 7 6 758 5 755 0 1028 ENPL_RAT reviewed Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) Hsp90b1 Grp94 Tra1 Rattus norvegicus (Rat) 804 cellular response to manganese ion [GO:0071287]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein folding [GO:0006457] GO:0005524; GO:0005788; GO:0005790; GO:0006457; GO:0030433; GO:0042470; GO:0071287 0 0 0 PF02518;PF00183; Q66HD0 CHOYP_ENPL.4.4 m.47194 sp ENPL_RAT 68.296 757 230 6 6 758 5 755 0 1013 ENPL_RAT reviewed Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) Hsp90b1 Grp94 Tra1 Rattus norvegicus (Rat) 804 cellular response to manganese ion [GO:0071287]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein folding [GO:0006457] GO:0005524; GO:0005788; GO:0005790; GO:0006457; GO:0030433; GO:0042470; GO:0071287 0 0 0 PF02518;PF00183; Q66HL2 CHOYP_SRC8.1.1 m.40902 sp SRC8_RAT 53.788 528 197 10 1 500 1 509 0 533 SRC8_RAT reviewed Src substrate cortactin Cttn Rattus norvegicus (Rat) 509 actin cytoskeleton reorganization [GO:0031532]; actin filament polymerization [GO:0030041]; brain development [GO:0007420]; cell motility [GO:0048870]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516] GO:0001726; GO:0002102; GO:0005886; GO:0005905; GO:0005925; GO:0006886; GO:0006898; GO:0007420; GO:0030027; GO:0030041; GO:0030054; GO:0030516; GO:0030838; GO:0030863; GO:0031532; GO:0043197; GO:0048041; GO:0048812; GO:0048870; GO:0070064; GO:0097581 0 0 0 PF02218;PF14604; Q66I21 CHOYP_AL8A1.1.1 m.13904 sp AL8A1_DANRE 62.839 479 176 1 10 486 8 486 0 645 AL8A1_DANRE reviewed Aldehyde dehydrogenase family 8 member A1 (EC 1.2.1.-) aldh8a1 Danio rerio (Zebrafish) (Brachydanio rerio) 487 liver development [GO:0001889] GO:0001758; GO:0001889; GO:0004029; GO:0005737 0 0 0 PF00171; Q66I24 CHOYP_ASSY.2.4 m.43713 sp ASSY_DANRE 70.5 400 118 0 7 406 6 405 0 624 ASSY_DANRE reviewed Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) ass1 ass zgc:92051 Danio rerio (Zebrafish) (Brachydanio rerio) 414 arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; urea cycle [GO:0000050] GO:0000050; GO:0000053; GO:0004055; GO:0005524; GO:0005737; GO:0006526 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.; PATHWAY: Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. 0 cd01999; PF00764; Q66J74 CHOYP_TFP11.1.1 m.65838 sp TFP11_XENLA 50.242 826 379 13 5 816 17 824 0 864 TFP11_XENLA reviewed Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1) tfip11 stip Xenopus laevis (African clawed frog) 824 "mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]" GO:0003677; GO:0005681; GO:0006355; GO:0006397; GO:0008380 0 0 0 PF01585;PF07842;PF12457; Q66L58 CHOYP_VAC14.1.1 m.31290 sp VAC14_DANRE 52.957 761 313 10 2 721 3 759 0 788 VAC14_DANRE reviewed Protein VAC14 homolog vac14 zgc:100945 Danio rerio (Zebrafish) (Brachydanio rerio) 771 regulation of lipid kinase activity [GO:0043550] GO:0010008; GO:0043550; GO:0070772 0 0 0 PF12755;PF11916; Q684M4 CHOYP_KEAP1.1.1 m.61750 sp KEAP1_PIG 54.895 572 252 2 24 589 42 613 0 640 KEAP1_PIG reviewed Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) KEAP1 INRF2 Sus scrofa (Pig) 624 "cytoplasmic sequestering of transcription factor [GO:0042994]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0008134; GO:0010499; GO:0016567; GO:0031463; GO:0042787; GO:0042994; GO:0043161; GO:0043433 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q68CZ1 CHOYP_BRAFLDRAFT_221898.1.2 m.28353 sp FTM_HUMAN 39.523 1341 724 23 7 1304 12 1308 0 932 FTM_HUMAN reviewed Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) 1315 camera-type eye development [GO:0043010]; cerebellum development [GO:0021549]; cilium assembly [GO:0042384]; cochlea development [GO:0090102]; corpus callosum development [GO:0022038]; determination of left/right symmetry [GO:0007368]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lateral ventricle development [GO:0021670]; liver development [GO:0001889]; negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744]; neural tube patterning [GO:0021532]; nose development [GO:0043584]; olfactory bulb development [GO:0021772]; pericardium development [GO:0060039]; regulation of smoothened signaling pathway [GO:0008589] GO:0001701; GO:0001736; GO:0001822; GO:0001889; GO:0005737; GO:0005813; GO:0005829; GO:0005911; GO:0005923; GO:0005929; GO:0005930; GO:0007163; GO:0007368; GO:0008589; GO:0021532; GO:0021549; GO:0021670; GO:0021772; GO:0022038; GO:0031870; GO:0035115; GO:0035116; GO:0035869; GO:0036064; GO:0042384; GO:0043010; GO:0043584; GO:0045744; GO:0060039; GO:0090102 0 0 0 PF00168;PF11618; Q68CZ1 CHOYP_LOC585739.1.1 m.63152 sp FTM_HUMAN 44.99 978 501 13 7 963 12 973 0 841 FTM_HUMAN reviewed Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) 1315 camera-type eye development [GO:0043010]; cerebellum development [GO:0021549]; cilium assembly [GO:0042384]; cochlea development [GO:0090102]; corpus callosum development [GO:0022038]; determination of left/right symmetry [GO:0007368]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lateral ventricle development [GO:0021670]; liver development [GO:0001889]; negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744]; neural tube patterning [GO:0021532]; nose development [GO:0043584]; olfactory bulb development [GO:0021772]; pericardium development [GO:0060039]; regulation of smoothened signaling pathway [GO:0008589] GO:0001701; GO:0001736; GO:0001822; GO:0001889; GO:0005737; GO:0005813; GO:0005829; GO:0005911; GO:0005923; GO:0005929; GO:0005930; GO:0007163; GO:0007368; GO:0008589; GO:0021532; GO:0021549; GO:0021670; GO:0021772; GO:0022038; GO:0031870; GO:0035115; GO:0035116; GO:0035869; GO:0036064; GO:0042384; GO:0043010; GO:0043584; GO:0045744; GO:0060039; GO:0090102 0 0 0 PF00168;PF11618; Q68FK8 CHOYP_BRAFLDRAFT_124637.1.1 m.26435 sp DHX9_XENLA 60.331 1210 447 13 1 1194 1 1193 0 1466 DHX9_XENLA reviewed ATP-dependent RNA helicase A-like protein (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) (NDH II) dhx9 Xenopus laevis (African clawed frog) 1262 0 GO:0003677; GO:0003723; GO:0005524; GO:0005634; GO:0008026; GO:0070937 0 0 0 PF00270;PF00035;PF04408;PF00271;PF07717; Q68FR8 CHOYP_TBA3.1.1 m.5111 sp TBA3_RAT 86.564 454 47 2 1 454 1 440 0 812 TBA3_RAT reviewed Tubulin alpha-3 chain (Alpha-tubulin 3) [Cleaved into: Detyrosinated tubulin alpha-3 chain] Tuba3a Tuba3; Tuba3b Tuba3 Rattus norvegicus (Rat) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0036064 0 0 0 PF00091;PF03953; Q68FT3 CHOYP_PYRD2.1.1 m.26691 sp PYRD2_RAT 58.392 572 227 5 24 584 10 581 0 680 PYRD2_RAT reviewed Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC 1.-.-.-) Pyroxd2 Rattus norvegicus (Rat) 581 0 GO:0016491 0 0 0 PF01593; Q69Z98 CHOYP_BRSK2.2.2 m.52471 sp BRSK2_MOUSE 64.353 634 188 13 6 604 5 635 0 792 BRSK2_MOUSE reviewed Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase SAD-A) Brsk2 Kiaa4256 Sada Mus musculus (Mouse) 735 actin cytoskeleton reorganization [GO:0031532]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitotic nuclear division [GO:0007067]; neuron differentiation [GO:0030182]; neuron projection morphogenesis [GO:0048812]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178] GO:0000086; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005813; GO:0006468; GO:0006887; GO:0007067; GO:0007409; GO:0018105; GO:0019901; GO:0030010; GO:0030182; GO:0031532; GO:0035556; GO:0036503; GO:0048471; GO:0048812; GO:0050321; GO:0051117; GO:0051301; GO:0061178; GO:0070059 0 0 0 PF00069; Q69ZJ7 CHOYP_BRAFLDRAFT_120211.1.1 m.9407 sp RIC1_MOUSE 43.475 1410 690 26 1 1355 1 1358 0 1117 RIC1_MOUSE reviewed RAB6A-GEF complex partner protein 1 (Protein RIC1 homolog) Ric1 Kiaa1432 Mus musculus (Mouse) 1422 "negative regulation of cellular protein catabolic process [GO:1903363]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005829; GO:0016020; GO:0016021; GO:0017112; GO:0017137; GO:0034066; GO:0042147; GO:0043234; GO:0043547; GO:1903363 0 0 0 PF07064; Q69ZN7 CHOYP_MYOF.2.3 m.15277 sp MYOF_MOUSE 47.696 2105 987 32 3 2055 2 2044 0 1870 MYOF_MOUSE reviewed Myoferlin (Fer-1-like protein 3) Myof Fer1l3 Kiaa1207 Mus musculus (Mouse) 2048 cellular response to heat [GO:0034605]; plasma membrane repair [GO:0001778]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947] GO:0001778; GO:0005543; GO:0005886; GO:0005901; GO:0016021; GO:0030659; GO:0030947; GO:0031410; GO:0031965; GO:0034605; GO:0043231; GO:0070062 0 0 0 PF00168;PF08165;PF08150;PF08151;PF16165; Q6A009 CHOYP_LTN1.1.2 m.7693 sp LTN1_MOUSE 34.313 1804 1048 40 8 1715 4 1766 0 982 LTN1_MOUSE reviewed E3 ubiquitin-protein ligase listerin (EC 6.3.2.-) (RING finger protein 160) (Zinc finger protein 294) (Zfp-294) Ltn1 Kiaa0714 Lister Rnf160 Zfp294 Znf294 Mus musculus (Mouse) 1767 protein autoubiquitination [GO:0051865] GO:0004842; GO:0008270; GO:0016874; GO:0051865; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q6AX60 CHOYP_PTHB1.1.1 m.35678 sp PTHB1_XENLA 52.404 832 381 8 1 824 1 825 0 877 PTHB1_XENLA reviewed Protein PTHB1 (Bardet-Biedl syndrome 9 protein homolog) (Parathyroid hormone-responsive B1 gene protein homolog) bbs9 pthb1 Xenopus laevis (African clawed frog) 849 0 GO:0005737; GO:0005815; GO:0005929; GO:0034464; GO:0060170 0 0 0 PF14728;PF14727; Q6AXC6 CHOYP_DDX11.1.1 m.16108 sp DDX11_MOUSE 48.144 889 398 13 42 903 22 874 0 822 DDX11_MOUSE reviewed Probable ATP-dependent DNA helicase DDX11 (EC 3.6.4.12) (DEAD/H box protein 11) Ddx11 Mus musculus (Mouse) 880 nucleobase-containing compound metabolic process [GO:0006139]; sister chromatid cohesion [GO:0007062] GO:0000790; GO:0000922; GO:0003690; GO:0003697; GO:0003723; GO:0004003; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006139; GO:0007062; GO:0008094; GO:0030496; GO:0046872; GO:0051539; GO:0070062 0 0 0 PF06733;PF13307; Q6AYJ1 CHOYP_NEMVEDRAFT_V1G174448.1.1 m.47533 sp RECQ1_RAT 48.689 610 309 1 7 612 10 619 0 646 RECQ1_RAT reviewed ATP-dependent DNA helicase Q1 (EC 3.6.4.12) (DNA-dependent ATPase Q1) (RecQ protein-like 1) Recql Recql1 Rattus norvegicus (Rat) 621 DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0003677; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006260; GO:0009378; GO:0016020; GO:0036310; GO:0043140 0 0 0 PF00270;PF00271;PF16124;PF09382; Q6AZN6 CHOYP_PK3C3.1.1 m.13959 sp PK3C3_XENLA 63.393 896 310 8 2 889 1 886 0 1151 PK3C3_XENLA reviewed Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphoinositide-3-kinase class 3) pik3c3 Xenopus laevis (African clawed frog) 886 autophagy [GO:0006914]; cytokinesis [GO:0000910]; phosphatidylinositol-mediated signaling [GO:0048015] GO:0000910; GO:0005524; GO:0005622; GO:0006914; GO:0016303; GO:0030496; GO:0048015 0 0 0 PF00454;PF00792;PF00613; Q6AZT2 CHOYP_SPAST.1.1 m.31607 sp SPAST_XENLA 52.605 595 217 14 29 599 43 596 0 555 SPAST_XENLA reviewed Spastin (EC 3.6.4.3) spast spg4 Xenopus laevis (African clawed frog) 600 anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cytokinetic process [GO:0032506]; ER to Golgi vesicle-mediated transport [GO:0006888]; exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; mitotic spindle disassembly [GO:0051228]; nuclear envelope reassembly [GO:0031468]; positive regulation of microtubule depolymerization [GO:0031117]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260] GO:0000281; GO:0001578; GO:0005524; GO:0005813; GO:0005819; GO:0005874; GO:0006888; GO:0007409; GO:0008017; GO:0008089; GO:0008568; GO:0010458; GO:0016021; GO:0019896; GO:0030496; GO:0031117; GO:0031468; GO:0031965; GO:0032506; GO:0034214; GO:0043014; GO:0048471; GO:0048487; GO:0051013; GO:0051228; GO:0051260; GO:0090148; GO:1904115 0 0 0 PF00004; Q6AZV7 CHOYP_DDX55.1.2 m.8319 sp DDX55_XENLA 57.895 589 238 4 5 590 4 585 0 699 DDX55_XENLA reviewed ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55) ddx55 Xenopus laevis (African clawed frog) 594 0 GO:0003723; GO:0004386; GO:0005524 0 0 0 PF00270;PF13959;PF00271; Q6DBY0 CHOYP_NUP85.1.1 m.16167 sp NUP85_DANRE 45.079 630 333 7 26 651 27 647 0 556 NUP85_DANRE reviewed Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (Nucleoporin Nup85) (Pericentrin-1) nup85 pcnt1 zgc:100943 Danio rerio (Zebrafish) (Brachydanio rerio) 649 "mRNA export from nucleus [GO:0006406]; positive regulation of transcription, DNA-templated [GO:0045893]; protein import into nucleus [GO:0006606]" GO:0006406; GO:0006606; GO:0017056; GO:0031080; GO:0031965; GO:0045893 0 0 0 PF07575; Q6DC04 CHOYP_LOC100743901.1.1 m.4559 sp CARM1_DANRE 58.88 518 193 9 53 557 57 567 0 607 CARM1_DANRE reviewed Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) carm1 si:dkey-204f11.63 zgc:100805 Danio rerio (Zebrafish) (Brachydanio rerio) 588 "histone arginine methylation [GO:0034969]; histone H3-R17 methylation [GO:0034971]; positive regulation of fat cell differentiation [GO:0045600]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of skeletal muscle fiber development [GO:0048742]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0008469; GO:0008757; GO:0016274; GO:0030374; GO:0033146; GO:0034969; GO:0034971; GO:0035242; GO:0035642; GO:0042054; GO:0044212; GO:0045600; GO:0048742; GO:0070577 0 0 0 PF11531;PF05185; Q6DCQ8 CHOYP_LOC655570.2.2 m.51799 sp P4K2B_XENLA 67.454 381 117 3 40 413 113 493 0 543 P4K2B_XENLA reviewed Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) pi4k2b TGas067g11.1 Xenopus laevis (African clawed frog) 495 0 GO:0004430; GO:0005524; GO:0005737; GO:0016020 0 0 0 PF00454; Q6DDT1 CHOYP_INO1A.1.1 m.91 sp INO1B_XENLA 69.703 505 151 2 4 508 5 507 0 745 INO1B_XENLA reviewed Inositol-3-phosphate synthase 1-B (IPS 1-B) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase B) (MI-1-P synthase B) (MIP synthase B) isyna1-b ino1-b Xenopus laevis (African clawed frog) 563 inositol biosynthetic process [GO:0006021]; phospholipid biosynthetic process [GO:0008654] GO:0004512; GO:0005737; GO:0006021; GO:0008654 PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2. 0 0 PF01658;PF07994; Q6DEY8 CHOYP_WDR67.1.1 m.4530 sp TBC31_XENTR 53.987 1091 468 9 1 1063 1 1085 0 1213 TBC31_XENTR reviewed TBC1 domain family member 31 (WD repeat-containing protein 67) tbc1d31 wdr67 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1088 0 GO:0005813 0 0 0 PF00566;PF00400; Q6DF08 CHOYP_BRAFLDRAFT_278567.1.1 m.18109 sp UXS1_XENTR 74 350 90 1 68 416 54 403 0 554 UXS1_XENTR reviewed UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UXS-1) uxs1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 421 UDP-D-xylose biosynthetic process [GO:0033320] GO:0016021; GO:0032580; GO:0033320; GO:0048040 PATHWAY: Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. 0 0 PF16363;PF11803; Q6DF08 CHOYP_UXS1.1.1 m.25712 sp UXS1_XENTR 74.504 353 87 2 68 420 54 403 0 557 UXS1_XENTR reviewed UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UXS-1) uxs1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 421 UDP-D-xylose biosynthetic process [GO:0033320] GO:0016021; GO:0032580; GO:0033320; GO:0048040 PATHWAY: Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1. 0 0 PF16363;PF11803; Q6DFB8 CHOYP_LOC100378002.1.1 m.47564 sp TTC37_XENLA 37.16 1359 789 21 18 1334 1 1336 0 776 TTC37_XENLA reviewed Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (Thespin homolog) ttc37 Xenopus laevis (African clawed frog) 1564 0 GO:0005634; GO:0005737; GO:0035327; GO:0055087 0 0 0 PF13181; Q6DFF6 CHOYP_KLH20.2.2 m.49641 sp KLH20_XENLA 85.49 572 83 0 50 621 33 604 0 1039 KLH20_XENLA reviewed Kelch-like protein 20 klhl20 Xenopus laevis (African clawed frog) 604 Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005802; GO:0005829; GO:0006895; GO:0015031; GO:0016567; GO:0016605; GO:0019964; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6DFF9 CHOYP_MABP1.1.2 m.21698 sp MABP1_XENLA 45.118 1055 503 20 5 1008 15 1044 0 910 MABP1_XENLA reviewed Mitogen-activated protein kinase-binding protein 1 mapkbp1 Xenopus laevis (African clawed frog) 1580 0 0 0 0 0 PF00400; Q6DFF9 CHOYP_MABP1.2.2 m.41219 sp MABP1_XENLA 45.024 1055 504 20 5 1008 15 1044 0 905 MABP1_XENLA reviewed Mitogen-activated protein kinase-binding protein 1 mapkbp1 Xenopus laevis (African clawed frog) 1580 0 0 0 0 0 PF00400; Q6DFM1 CHOYP_EF-1A.9.9 m.63037 sp SNF5_XENTR 72.296 379 98 3 1 373 1 378 0 583 SNF5_XENTR reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 smarcb1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 378 "ATP-dependent chromatin remodeling [GO:0043044]; cell differentiation [GO:0030154]; DNA repair [GO:0006281]; negative regulation of cell proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0006281; GO:0006337; GO:0006351; GO:0006357; GO:0008285; GO:0030154; GO:0043044; GO:0090544 0 0 0 PF04855; Q6DFR2 CHOYP_ISCW_ISCW019991.1.5 m.8713 sp CBLB_XENTR 61.051 552 171 8 5 540 21 544 0 670 CBLB_XENTR reviewed E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) cblb Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 982 cell surface receptor signaling pathway [GO:0007166]; regulation of signaling [GO:0023051] GO:0004842; GO:0004871; GO:0005509; GO:0005634; GO:0005737; GO:0007166; GO:0008270; GO:0016874; GO:0023051 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02262;PF02761;PF02762; Q6DFR2 CHOYP_ISCW_ISCW019991.2.5 m.18105 sp CBLB_XENTR 66.94 487 142 6 5 487 40 511 0 671 CBLB_XENTR reviewed E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) cblb Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 982 cell surface receptor signaling pathway [GO:0007166]; regulation of signaling [GO:0023051] GO:0004842; GO:0004871; GO:0005509; GO:0005634; GO:0005737; GO:0007166; GO:0008270; GO:0016874; GO:0023051 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02262;PF02761;PF02762; Q6DFR2 CHOYP_ISCW_ISCW019991.3.5 m.25720 sp CBLB_XENTR 61.051 552 171 8 15 550 21 544 0 668 CBLB_XENTR reviewed E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) cblb Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 982 cell surface receptor signaling pathway [GO:0007166]; regulation of signaling [GO:0023051] GO:0004842; GO:0004871; GO:0005509; GO:0005634; GO:0005737; GO:0007166; GO:0008270; GO:0016874; GO:0023051 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02262;PF02761;PF02762; Q6DFR2 CHOYP_ISCW_ISCW019991.4.5 m.36874 sp CBLB_XENTR 71.801 422 117 1 17 436 21 442 0 660 CBLB_XENTR reviewed E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) cblb Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 982 cell surface receptor signaling pathway [GO:0007166]; regulation of signaling [GO:0023051] GO:0004842; GO:0004871; GO:0005509; GO:0005634; GO:0005737; GO:0007166; GO:0008270; GO:0016874; GO:0023051 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02262;PF02761;PF02762; Q6DFR2 CHOYP_ISCW_ISCW019991.5.5 m.63665 sp CBLB_XENTR 65.02 506 159 5 15 517 21 511 0 673 CBLB_XENTR reviewed E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) cblb Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 982 cell surface receptor signaling pathway [GO:0007166]; regulation of signaling [GO:0023051] GO:0004842; GO:0004871; GO:0005509; GO:0005634; GO:0005737; GO:0007166; GO:0008270; GO:0016874; GO:0023051 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02262;PF02761;PF02762; Q6DFV1 CHOYP_LOC583107.1.1 m.8028 sp CNDG2_MOUSE 33.391 1159 712 21 1 1123 1 1135 0 603 CNDG2_MOUSE reviewed Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (Leucine zipper protein 5) (More than blood protein) (Non-SMC condensin II complex subunit G2) Ncapg2 Luzp5 Mtb Mus musculus (Mouse) 1138 cell division [GO:0051301]; chromosome condensation [GO:0030261]; inner cell mass cell proliferation [GO:0001833]; mitotic nuclear division [GO:0007067] GO:0001833; GO:0005634; GO:0007067; GO:0016020; GO:0030261; GO:0035064; GO:0051301 0 0 0 PF12422; Q6DHR3 CHOYP_RG1BA.1.1 m.10888 sp RG1BA_DANRE 53.346 508 207 6 129 629 25 509 0 544 RG1BA_DANRE reviewed Ras-GEF domain-containing family member 1B-A rasgef1ba rasgef1b si:dkey-18e17.1 Danio rerio (Zebrafish) (Brachydanio rerio) 514 small GTPase mediated signal transduction [GO:0007264] GO:0005088; GO:0005622; GO:0007264 0 0 cd06224; PF00617;PF00618; Q6DKB0 CHOYP_LOC100642349.1.1 m.53035 sp 5NTC_XENLA 55.179 531 216 8 22 539 25 546 0 587 5NTC_XENLA reviewed Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II) nt5c2 Xenopus laevis (African clawed frog) 569 nucleotide metabolic process [GO:0009117] GO:0000166; GO:0005737; GO:0008253; GO:0009117; GO:0046872 0 0 0 PF05761; Q6DKE2 CHOYP_DVL.2.2 m.40553 sp DVL3_XENLA 63.811 572 164 14 1 544 1 557 0 634 DVL3_XENLA reviewed Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3) dvl3 Xenopus laevis (African clawed frog) 717 ciliary basal body organization [GO:0032053]; cilium assembly [GO:0042384]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005737; GO:0007275; GO:0008013; GO:0016055; GO:0032053; GO:0035556; GO:0042384 0 0 0 PF00610;PF02377;PF00778;PF12316;PF00595; Q6DN14 CHOYP_LOC100748072.1.1 m.46992 sp MCTP1_HUMAN 45.992 761 351 11 180 885 238 993 0 644 MCTP1_HUMAN reviewed Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) 999 calcium-mediated signaling [GO:0019722] GO:0005509; GO:0005783; GO:0016021; GO:0019722 0 0 0 PF00168;PF08372; Q6DN14 CHOYP_LOC100900285.1.1 m.24143 sp MCTP1_HUMAN 46.774 744 336 11 213 901 255 993 0 642 MCTP1_HUMAN reviewed Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) 999 calcium-mediated signaling [GO:0019722] GO:0005509; GO:0005783; GO:0016021; GO:0019722 0 0 0 PF00168;PF08372; Q6DN14 CHOYP_LOC574791.1.1 m.22986 sp MCTP1_HUMAN 46.577 745 339 10 195 886 255 993 0 641 MCTP1_HUMAN reviewed Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) 999 calcium-mediated signaling [GO:0019722] GO:0005509; GO:0005783; GO:0016021; GO:0019722 0 0 0 PF00168;PF08372; Q6DRN3 CHOYP_NOC3L.1.1 m.7432 sp NOC3L_DANRE 47.826 690 325 9 130 806 122 789 0 596 NOC3L_DANRE reviewed Nucleolar complex protein 3 homolog (NOC3 protein homolog) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) noc3l Danio rerio (Zebrafish) (Brachydanio rerio) 800 muscle organ development [GO:0007517]; regulation of lipid metabolic process [GO:0019216] GO:0003682; GO:0005634; GO:0005730; GO:0007517; GO:0019216 0 0 0 PF03914;PF07540; Q6DUZ9 CHOYP_TSSC1.1.1 m.66470 sp TSSC1_GEKJA 65.172 379 122 3 1 369 1 379 0 528 TSSC1_GEKJA reviewed Protein TSSC1 TSSC1 GekBS030P Gekko japonicus (Schlegel's Japanese gecko) 387 0 0 0 0 0 PF00400; Q6EE31 CHOYP_TCPQ.1.1 m.57792 sp TCPQ_CHICK 68.44 545 171 1 1 544 1 545 0 791 TCPQ_CHICK reviewed T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) CCT8 Gallus gallus (Chicken) 548 protein folding [GO:0006457] GO:0005524; GO:0005737; GO:0005815; GO:0006457 0 0 cd03341; PF00118; Q6GL41 CHOYP_MCM4.1.1 m.61253 sp MCM4_XENTR 68.239 869 256 7 44 900 2 862 0 1228 MCM4_XENTR reviewed DNA replication licensing factor mcm4 (EC 3.6.4.12) (Minichromosome maintenance protein 4) mcm4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 863 cell cycle [GO:0007049]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000785; GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0006268; GO:0006270; GO:0007049; GO:0030174; GO:0042555; GO:0046872 0 0 0 PF00493;PF14551; Q6GM29 CHOYP_SAC1.1.1 m.40164 sp SAC1_XENLA 56.357 582 249 3 7 587 4 581 0 722 SAC1_XENLA reviewed Phosphatidylinositide phosphatase SAC1 (EC 3.1.3.-) (Suppressor of actin mutations 1-like protein) sacm1l Xenopus laevis (African clawed frog) 586 phosphatidylinositol dephosphorylation [GO:0046856] GO:0005789; GO:0016021; GO:0016791; GO:0043812; GO:0046856 0 0 0 PF02383; Q6GM65 CHOYP_BRAFLDRAFT_60329.1.1 m.18239 sp PLAP_XENLA 49.937 795 376 11 4 784 13 799 0 810 PLAP_XENLA reviewed Phospholipase A-2-activating protein (PLA2P) (PLAP) plaa Xenopus laevis (African clawed frog) 799 0 0 0 0 0 PF09070;PF08324;PF00400; Q6GM82 CHOYP_ALAT2.1.1 m.15163 sp ALAT2_XENLA 62.729 491 171 5 28 516 58 538 0 640 ALAT2_XENLA reviewed Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) gpt2 Xenopus laevis (African clawed frog) 540 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851] GO:0004021; GO:0006103; GO:0009058; GO:0030170; GO:0042851; GO:0042853 PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. 0 0 PF00155; Q6GMF8 CHOYP_RHDF1.1.3 m.36049 sp RHDF1_DANRE 39.849 793 391 17 49 769 75 853 0 572 RHDF1_DANRE reviewed Inactive rhomboid protein 1 (iRhom1) (Rhomboid family member 1) rhbdf1 zgc:91984 Danio rerio (Zebrafish) (Brachydanio rerio) 857 cell migration [GO:0016477]; cell proliferation [GO:0008283]; negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; proteolysis [GO:0006508]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708] GO:0000139; GO:0005789; GO:0006508; GO:0008283; GO:0015031; GO:0016021; GO:0016477; GO:0042058; GO:0050708; GO:0050709; GO:0061136 0 0 cd06174; PF01694;PF12595; Q6GMK8 CHOYP_GMPAA.1.1 m.1432 sp GMPAA_DANRE 63.573 431 148 2 14 444 1 422 0 582 GMPAA_DANRE reviewed Mannose-1-phosphate guanyltransferase alpha-A (EC 2.7.7.13) (GDP-mannose pyrophosphorylase A-A) (GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A) gmppaa zgc:91853 Danio rerio (Zebrafish) (Brachydanio rerio) 422 GDP-mannose biosynthetic process [GO:0009298] GO:0004475; GO:0005525; GO:0009298 PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. 0 0 PF00132;PF00483; Q6GN02 CHOYP_BRAFLDRAFT_268929.1.1 m.35239 sp THILB_XENLA 70.05 404 120 1 13 415 17 420 0 567 THILB_XENLA reviewed "Acetyl-CoA acetyltransferase B, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase B)" acat1-b Xenopus laevis (African clawed frog) 420 metabolic process [GO:0008152] GO:0003985; GO:0005739; GO:0008152; GO:0046872 0 0 0 PF02803;PF00108; Q6GNL7 CHOYP_LOC100377034.1.1 m.6251 sp AL1L1_XENLA 71.539 903 253 4 48 947 1 902 0 1355 AL1L1_XENLA reviewed Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) aldh1l1 Xenopus laevis (African clawed frog) 902 10-formyltetrahydrofolate catabolic process [GO:0009258]; biosynthetic process [GO:0009058]; one-carbon metabolic process [GO:0006730] GO:0005737; GO:0006730; GO:0009058; GO:0009258; GO:0016155; GO:0016620; GO:0016742 0 0 0 PF00171;PF02911;PF00551; Q6GP52 CHOYP_BECN1.1.1 m.29596 sp BECN1_XENLA 62.611 452 142 8 8 442 4 445 0 543 BECN1_XENLA reviewed Beclin-1 becn1 Xenopus laevis (African clawed frog) 445 autophagy [GO:0006914]; cytokinesis [GO:0000910]; defense response to virus [GO:0051607]; endocytosis [GO:0006897]; positive regulation of autophagy [GO:0010508]; regulation of cytokinesis [GO:0032465] GO:0000139; GO:0000910; GO:0006897; GO:0006914; GO:0010508; GO:0032465; GO:0051607 0 0 0 PF04111;PF15285; Q6GPD0 CHOYP_LOC656615.1.1 m.66274 sp RHG32_XENLA 54.266 586 247 11 60 635 98 672 0 652 RHG32_XENLA reviewed Rho GTPase-activating protein 32 (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) arhgap32 rics Xenopus laevis (African clawed frog) 1940 signal transduction [GO:0007165] GO:0005096; GO:0005737; GO:0005886; GO:0007165; GO:0035091 0 0 0 PF00620;PF07653; Q6GPF3 CHOYP_CUL3B.1.1 m.61643 sp CUL3B_XENLA 79.051 759 152 3 9 761 11 768 0 1267 CUL3B_XENLA reviewed Cullin-3-B (CUL-3-B) cul3b Xenopus laevis (African clawed frog) 768 cell migration [GO:0016477]; COPII vesicle coating [GO:0048208]; embryonic cleavage [GO:0040016]; ER to Golgi vesicle-mediated transport [GO:0006888]; integrin-mediated signaling pathway [GO:0007229]; mitotic metaphase plate congression [GO:0007080]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; stem cell division [GO:0017145]; stress fiber assembly [GO:0043149] GO:0000139; GO:0005634; GO:0005827; GO:0006513; GO:0006888; GO:0007080; GO:0007229; GO:0016477; GO:0016567; GO:0017145; GO:0031463; GO:0035024; GO:0040016; GO:0043149; GO:0043161; GO:0045842; GO:0048208 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00888;PF10557; Q6GQ29 CHOYP_CBPQ.1.1 m.58629 sp CBPQ_XENLA 63.048 433 160 0 52 484 37 469 0 580 CBPQ_XENLA reviewed Carboxypeptidase Q (EC 3.4.17.-) (Plasma glutamate carboxypeptidase) cpq pgcp Xenopus laevis (African clawed frog) 469 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004180; GO:0005615; GO:0005737; GO:0005764; GO:0005783; GO:0005794; GO:0006508; GO:0042803; GO:0043171; GO:0046872; GO:0070573 0 0 0 PF04389; Q6GQB9 CHOYP_EDEM3.1.1 m.12489 sp EDEM3_XENLA 55.417 803 322 8 31 817 10 792 0 915 EDEM3_XENLA reviewed "ER degradation-enhancing alpha-mannosidase-like protein 3 (EC 3.2.1.113) (Alpha-1,2-mannosidase EDEM3)" edem3 Xenopus laevis (African clawed frog) 913 protein glycosylation [GO:0006486]; response to unfolded protein [GO:0006986] GO:0004571; GO:0005509; GO:0005788; GO:0006486; GO:0006986; GO:0016020 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P32906}. 0 0 PF01532;PF02225; Q6GQJ2 CHOYP_BRAFLDRAFT_123304.1.1 m.29231 sp JADE1_XENLA 54.582 502 207 8 41 529 31 524 0 568 JADE1_XENLA reviewed Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) jade1 phf17 Xenopus laevis (African clawed frog) 827 "apoptotic process [GO:0006915]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006915; GO:0008270 0 0 0 PF10513; Q6GVH4 CHOYP_GGNB2.1.1 m.57824 sp GGNB2_CHICK 56.069 519 201 10 24 527 1 507 0 548 GGNB2_CHICK reviewed Gametogenetin-binding protein 2 (Protein ZNF403) GGNBP2 ZNF403 RCJMB04_15h5 Gallus gallus (Chicken) 698 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q6IDD9 CHOYP_AAEL_AAEL014931.1.1 m.24932 sp SARM1_DROME 54.792 626 259 7 239 855 372 982 0 716 SARM1_DROME reviewed Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog) (dSarm) Ect4 dsarm CG43119 Drosophila melanogaster (Fruit fly) 1360 innate immune response [GO:0045087]; regulation of neuron death [GO:1901214]; response to axon injury [GO:0048678]; signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0030424; GO:0043005; GO:0043025; GO:0045087; GO:0048678; GO:1901214 0 0 0 PF07647;PF13676; Q6IDD9 CHOYP_SARM1.1.1 m.377 sp SARM1_DROME 54.545 660 269 7 210 862 372 1007 0 719 SARM1_DROME reviewed Sterile alpha and TIR motif-containing protein 1 (Tir-1 homolog) (dSarm) Ect4 dsarm CG43119 Drosophila melanogaster (Fruit fly) 1360 innate immune response [GO:0045087]; regulation of neuron death [GO:1901214]; response to axon injury [GO:0048678]; signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0030424; GO:0043005; GO:0043025; GO:0045087; GO:0048678; GO:1901214 0 0 0 PF07647;PF13676; Q6INC1 CHOYP_BRAFLDRAFT_128460.2.2 m.49336 sp TT21B_XENLA 45.152 1413 667 15 1 1407 1 1311 0 1229 TT21B_XENLA reviewed Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) ttc21b Xenopus laevis (African clawed frog) 1312 0 GO:0030991 0 0 0 PF13176;PF13181; Q6ING7 CHOYP_LOC593348.1.1 m.18196 sp FLAD1_XENLA 53.209 483 222 2 29 510 16 495 0 533 FLAD1_XENLA reviewed FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] flad1 Xenopus laevis (African clawed frog) 496 FAD biosynthetic process [GO:0006747] GO:0003919; GO:0005524; GO:0005737; GO:0006747 PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. 0 cd01713; PF00994;PF01507; Q6INN8 CHOYP_SAMH1.12.12 m.66249 sp SAMH1_XENLA 55.296 557 238 7 57 606 50 602 0 604 SAMH1_XENLA reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Xenopus laevis (African clawed frog) 632 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966;PF07647; Q6INU8 CHOYP_TT30A.1.1 m.28332 sp TT30A_XENLA 77.726 642 143 0 5 646 5 646 0 1061 TT30A_XENLA reviewed Tetratricopeptide repeat protein 30A (TPR repeat protein 30A) ttc30a ttc30 Xenopus laevis (African clawed frog) 651 intraciliary transport [GO:0042073]; protein polyglutamylation [GO:0018095] GO:0005215; GO:0005879; GO:0005929; GO:0018095; GO:0042073 0 0 0 PF13174; Q6INX4 CHOYP_LOC754396.1.1 m.39126 sp ENOF1_XENLA 58.716 436 178 1 6 439 5 440 0 584 ENOF1_XENLA reviewed Mitochondrial enolase superfamily member 1 (L-fuconate dehydratase) (EC 4.2.1.68) enosf1 Xenopus laevis (African clawed frog) 445 cellular carbohydrate catabolic process [GO:0044275] GO:0000287; GO:0005739; GO:0016853; GO:0044275; GO:0050023 0 0 0 PF13378;PF02746; Q6IP59 CHOYP_CTL2.1.2 m.3857 sp CTL2_XENLA 44.549 743 349 16 87 801 2 709 0 604 CTL2_XENLA reviewed Choline transporter-like protein 2 (Solute carrier family 44 member 2) slc44a2 ctl2 Xenopus laevis (African clawed frog) 710 transport [GO:0006810] GO:0006810; GO:0016021 0 0 0 PF04515; Q6IQ26 CHOYP_DEN5A.1.1 m.24392 sp DEN5A_HUMAN 50.378 1322 562 21 5 1276 10 1287 0 1281 DEN5A_HUMAN reviewed DENN domain-containing protein 5A (Rab6-interacting protein 1) (Rab6IP1) DENND5A KIAA1091 RAB6IP1 Homo sapiens (Human) 1287 "detection of mechanical stimulus [GO:0050982]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005262; GO:0005802; GO:0005829; GO:0017112; GO:0042147; GO:0050982 0 0 0 PF03455;PF02141;PF01477;PF02759;PF03456; Q6IR74 CHOYP_BRAFLDRAFT_130395.1.1 m.38394 sp CTL1_XENLA 45.083 661 323 13 3 646 2 639 0 572 CTL1_XENLA reviewed Choline transporter-like protein 1 (Solute carrier family 44 member 1) slc44a1 ctl1 Xenopus laevis (African clawed frog) 651 0 GO:0016021 0 0 0 PF04515; Q6IR75 CHOYP_CSN2.1.1 m.28636 sp CSN2_XENLA 87.016 439 56 1 18 456 2 439 0 786 CSN2_XENLA reviewed COP9 signalosome complex subunit 2 (Signalosome subunit 2) (Fragment) csn2 Xenopus laevis (African clawed frog) 441 0 GO:0005737; GO:0008180 0 0 0 PF01399; Q6JAN0 CHOYP_BRAFLDRAFT_102479.1.1 m.8179 sp GPR98_DANRE 33.612 3353 1977 88 2 3269 3011 6199 0 1556 GPR98_DANRE reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) gpr98 mass1 vlgr1 Danio rerio (Zebrafish) (Brachydanio rerio) 6199 cell surface receptor signaling pathway [GO:0007166]; eye photoreceptor cell development [GO:0042462] GO:0004930; GO:0005886; GO:0007166; GO:0016021; GO:0042462 0 0 0 PF00002;PF03160; Q6JEL2 CHOYP_KLHL10.2.2 m.50718 sp KLH10_HUMAN 55.95 563 248 0 15 577 19 581 0 686 KLH10_HUMAN reviewed Kelch-like protein 10 KLHL10 Homo sapiens (Human) 608 cell morphogenesis [GO:0000902]; fertilization [GO:0009566]; homeostasis of number of cells within a tissue [GO:0048873]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]; spermatid development [GO:0007286] GO:0000902; GO:0005737; GO:0007286; GO:0008584; GO:0009566; GO:0016567; GO:0031463; GO:0048808; GO:0048873 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6JHU9 CHOYP_CBP.2.4 m.11401 sp CBP_RAT 63.987 958 276 14 859 1806 975 1873 0 1234 CBP_RAT reviewed CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) 2442 "cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; histone acetylation [GO:0016573]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003682; GO:0003684; GO:0003713; GO:0004402; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0008283; GO:0016407; GO:0016573; GO:0016604; GO:0033613; GO:0034644; GO:0042975; GO:0043234; GO:0043426; GO:0045893; GO:0045944; GO:0046332; GO:0048511; GO:0060355; GO:0070555; GO:0098609; GO:1900087; GO:1901224 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q6JHU9 CHOYP_CBP.3.4 m.33270 sp CBP_RAT 64.768 948 275 13 783 1720 975 1873 0 1238 CBP_RAT reviewed CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) 2442 "cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; histone acetylation [GO:0016573]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003682; GO:0003684; GO:0003713; GO:0004402; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0008283; GO:0016407; GO:0016573; GO:0016604; GO:0033613; GO:0034644; GO:0042975; GO:0043234; GO:0043426; GO:0045893; GO:0045944; GO:0046332; GO:0048511; GO:0060355; GO:0070555; GO:0098609; GO:1900087; GO:1901224 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q6JHU9 CHOYP_LOC664565.1.1 m.28567 sp CBP_RAT 64.092 958 275 14 772 1719 975 1873 0 1235 CBP_RAT reviewed CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) 2442 "cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; histone acetylation [GO:0016573]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003682; GO:0003684; GO:0003713; GO:0004402; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0008283; GO:0016407; GO:0016573; GO:0016604; GO:0033613; GO:0034644; GO:0042975; GO:0043234; GO:0043426; GO:0045893; GO:0045944; GO:0046332; GO:0048511; GO:0060355; GO:0070555; GO:0098609; GO:1900087; GO:1901224 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q6JHU9 CHOYP_LOC664565.1.1 m.28568 sp CBP_RAT 64.204 961 269 16 307 1254 975 1873 0 1229 CBP_RAT reviewed CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) 2442 "cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; histone acetylation [GO:0016573]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003682; GO:0003684; GO:0003713; GO:0004402; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0008283; GO:0016407; GO:0016573; GO:0016604; GO:0033613; GO:0034644; GO:0042975; GO:0043234; GO:0043426; GO:0045893; GO:0045944; GO:0046332; GO:0048511; GO:0060355; GO:0070555; GO:0098609; GO:1900087; GO:1901224 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q6KAR6 CHOYP_BRAFLDRAFT_119363.1.1 m.41627 sp EXOC3_MOUSE 44.052 765 400 13 13 768 9 754 0 634 EXOC3_MOUSE reviewed Exocyst complex component 3 (Exocyst complex component Sec6) Exoc3 Sec6l1 Mus musculus (Mouse) 755 exocyst localization [GO:0051601]; exocytosis [GO:0006887]; membrane organization [GO:0061024]; protein transport [GO:0015031] GO:0000145; GO:0000149; GO:0006887; GO:0015031; GO:0030667; GO:0051601; GO:0061024 0 0 0 PF06046; Q6KCD5 CHOYP_NIPLB.1.1 m.11155 sp NIPBL_MOUSE 51.854 1591 636 23 281 1830 1123 2624 0 1544 NIPBL_MOUSE reviewed Nipped-B-like protein (Delangin homolog) (SCC2 homolog) Nipbl Mus musculus (Mouse) 2798 "brain development [GO:0007420]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to X-ray [GO:0071481]; cognition [GO:0050890]; developmental growth [GO:0048589]; ear morphogenesis [GO:0042471]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; external genitalia morphogenesis [GO:0035261]; eye morphogenesis [GO:0048592]; face morphogenesis [GO:0060325]; fat cell differentiation [GO:0045444]; forelimb morphogenesis [GO:0035136]; gall bladder development [GO:0061010]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of ossification [GO:0045778]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of developmental growth [GO:0048638]; regulation of embryonic development [GO:0045995]; regulation of hair cycle [GO:0042634]; sensory perception of sound [GO:0007605]; stem cell population maintenance [GO:0019827]; uterus morphogenesis [GO:0061038]" GO:0000122; GO:0000785; GO:0003007; GO:0003151; GO:0003682; GO:0005634; GO:0006974; GO:0007064; GO:0007420; GO:0007507; GO:0007605; GO:0008022; GO:0019827; GO:0031065; GO:0032116; GO:0034088; GO:0034613; GO:0035115; GO:0035136; GO:0035261; GO:0036033; GO:0040018; GO:0042471; GO:0042634; GO:0042826; GO:0045444; GO:0045778; GO:0045892; GO:0045944; GO:0045995; GO:0047485; GO:0048557; GO:0048589; GO:0048592; GO:0048638; GO:0048701; GO:0048703; GO:0050890; GO:0060325; GO:0061010; GO:0061038; GO:0070062; GO:0070087; GO:0071481 0 0 0 PF12765;PF12830; Q6NRC9 CHOYP_LOC100553117.1.1 m.14863 sp LRCC1_XENLA 41.143 1050 564 14 1 1016 1 1030 0 692 LRCC1_XENLA reviewed Leucine-rich repeat and coiled-coil domain-containing protein 1 lrrcc1 Xenopus laevis (African clawed frog) 1030 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005814; GO:0007067; GO:0051301 0 0 0 PF12799; Q6NRL1 CHOYP_CEG1A.1.6 m.815 sp AGAP1_XENLA 47.912 910 319 19 8 844 4 831 0 780 AGAP1_XENLA reviewed "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2)" agap1 centg2 Xenopus laevis (African clawed frog) 864 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0005096; GO:0005525; GO:0005737; GO:0007264; GO:0015031; GO:0046872 0 0 0 PF01412;PF00071; Q6NRL6 CHOYP_LOC101157789.1.1 m.43475 sp SYVNA_XENLA 54.473 626 228 11 6 595 1 605 0 605 SYVNA_XENLA reviewed E3 ubiquitin-protein ligase synoviolin A (EC 6.3.2.-) (Synovial apoptosis inhibitor-1-A) syvn1-a hrd1-a Xenopus laevis (African clawed frog) 605 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein N-linked glycosylation via asparagine [GO:0018279] GO:0000836; GO:0008270; GO:0016021; GO:0016874; GO:0018279; GO:0030433; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q6NRP2 CHOYP_PSME4.1.1 m.18992 sp PSME4_XENLA 47.448 1861 912 25 24 1855 5 1828 0 1719 PSME4_XENLA reviewed Proteasome activator complex subunit 4 (Proteasome activator PA200) psme4 Xenopus laevis (African clawed frog) 1828 "cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]" GO:0005634; GO:0005829; GO:0006281; GO:0006974; GO:0010499; GO:0016504; GO:0016607; GO:0035093; GO:0070577; GO:1990111 0 0 0 PF16507;PF11919; Q6NRS1 CHOYP_IBTK.1.1 m.647 sp IBTK_XENLA 40.059 1363 695 24 7 1279 6 1336 0 951 IBTK_XENLA reviewed Inhibitor of Bruton tyrosine kinase (IBtk) ibtk Xenopus laevis (African clawed frog) 1339 0 GO:0005737; GO:0016020 0 0 0 PF12796;PF00651;PF00415; Q6NRT3 CHOYP_SMU1.1.1 m.58635 sp SMU1_XENLA 82.846 513 88 0 1 513 1 513 0 931 SMU1_XENLA reviewed WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) smu1 Xenopus laevis (African clawed frog) 513 0 GO:0005634; GO:0005737 0 0 0 PF00400; Q6NRT5 CHOYP_BRAFLDRAFT_116394.1.1 m.57079 sp CSN1_XENLA 74.788 472 116 2 27 495 1 472 0 715 CSN1_XENLA reviewed COP9 signalosome complex subunit 1 (Signalosome subunit 1) csn1 Xenopus laevis (African clawed frog) 487 COP9 signalosome assembly [GO:0010387]; cullin deneddylation [GO:0010388] GO:0005737; GO:0008180; GO:0010387; GO:0010388 0 0 0 PF01399;PF10602; Q6NRY2 CHOYP_NOL6.1.2 m.8340 sp NOL6_XENLA 44.164 1148 602 16 25 1153 14 1141 0 945 NOL6_XENLA reviewed Nucleolar protein 6 nol6 Xenopus laevis (African clawed frog) 1147 0 GO:0003723; GO:0005730 0 0 0 PF03813; Q6NRZ1 CHOYP_LOC101159151.1.1 m.54008 sp UH1BL_XENLA 31.991 1391 786 37 1 1322 1 1300 0 644 UH1BL_XENLA reviewed UHRF1-binding protein 1-like uhrf1bp1l Xenopus laevis (African clawed frog) 1415 0 0 0 0 0 PF12624; Q6NS52 CHOYP_DGKB.1.1 m.49869 sp DGKB_MOUSE 64.222 668 208 10 214 867 132 782 0 906 DGKB_MOUSE reviewed Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) Dgkb Kiaa0718 Mus musculus (Mouse) 802 intracellular signal transduction [GO:0035556]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205] GO:0004143; GO:0005509; GO:0005524; GO:0005737; GO:0005886; GO:0007205; GO:0035556 0 0 0 PF00130;PF14513;PF00609;PF00781;PF13499; Q6NS52 CHOYP_LOC100116104.1.1 m.24927 sp DGKB_MOUSE 64.264 666 199 8 297 938 132 782 0 913 DGKB_MOUSE reviewed Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) Dgkb Kiaa0718 Mus musculus (Mouse) 802 intracellular signal transduction [GO:0035556]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205] GO:0004143; GO:0005509; GO:0005524; GO:0005737; GO:0005886; GO:0007205; GO:0035556 0 0 0 PF00130;PF14513;PF00609;PF00781;PF13499; Q6NSN2 CHOYP_AOF.1.1 m.7109 sp AOF_DANRE 59.237 498 202 1 10 507 7 503 0 619 AOF_DANRE reviewed Amine oxidase [flavin-containing] (EC 1.4.3.4) (Monoamine oxidase) (MAO) (Z-MAO) mao zgc:85761 Danio rerio (Zebrafish) (Brachydanio rerio) 522 catecholamine metabolic process [GO:0006584]; cellular biogenic amine catabolic process [GO:0042402]; neurotransmitter catabolic process [GO:0042135] GO:0005741; GO:0006584; GO:0008131; GO:0016021; GO:0042135; GO:0042402 0 0 0 PF01593; Q6NSR8 CHOYP_LOC656899.1.1 m.15417 sp PEPL1_MOUSE 57.885 520 214 3 3 518 4 522 0 598 PEPL1_MOUSE reviewed Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1) Npepl1 Mus musculus (Mouse) 524 0 GO:0004177; GO:0005634; GO:0005737; GO:0008235; GO:0030145 0 0 cd00433; PF00883; Q6NTN5 CHOYP_LOC100645183.1.1 m.53488 sp MTMRD_XENLA 45.896 1852 863 37 1 1820 1 1745 0 1603 MTMRD_XENLA reviewed Myotubularin-related protein 13 (SET-binding factor 2) sbf2 mtmr13 Xenopus laevis (African clawed frog) 1873 0 GO:0005085; GO:0005737; GO:0016020; GO:0019208 0 0 0 PF02141;PF02893;PF06602;PF00169;PF12335;PF03456; Q6NU40 CHOYP_CTF18.1.1 m.15870 sp CTF18_XENLA 41.517 1002 470 24 5 903 12 1000 0 660 CTF18_XENLA reviewed Chromosome transmission fidelity protein 18 homolog chtf18 ctf18 Xenopus laevis (African clawed frog) 1000 cell cycle [GO:0007049]; DNA replication [GO:0006260] GO:0003689; GO:0005524; GO:0005634; GO:0005663; GO:0006260; GO:0007049 0 0 0 PF00004;PF08519; Q6NUQ1 CHOYP_RINT1.1.1 m.9402 sp RINT1_HUMAN 42.416 712 383 8 54 753 90 786 0 563 RINT1_HUMAN reviewed RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) RINT1 Homo sapiens (Human) 792 "cell cycle [GO:0007049]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of signal transduction involved in mitotic G2 DNA damage checkpoint [GO:1902504]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0005783; GO:0005789; GO:0005829; GO:0006890; GO:0007049; GO:0015031; GO:0060628; GO:0070939; GO:1902504 0 0 0 PF04437; Q6NV04 CHOYP_ILVBL.1.1 m.27563 sp ILVBL_DANRE 68.669 616 192 1 18 633 7 621 0 910 ILVBL_DANRE reviewed Acetolactate synthase-like protein (EC 2.2.1.-) (IlvB-like protein) ilvbl zgc:66376 zgc:85697 Danio rerio (Zebrafish) (Brachydanio rerio) 621 embryonic cranial skeleton morphogenesis [GO:0048701] GO:0000287; GO:0016021; GO:0016740; GO:0030976; GO:0048701 0 0 0 PF02775;PF00205;PF02776; Q6NV83 CHOYP_SR140.1.2 m.11983 sp SR140_MOUSE 50.806 992 345 24 37 930 73 1019 0 799 SR140_MOUSE reviewed U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140) U2surp Sr140 Mus musculus (Mouse) 1029 RNA processing [GO:0006396] GO:0000166; GO:0005634; GO:0005654; GO:0006396; GO:0044822 0 0 0 PF08312;PF00076;PF01805; Q6NVF0 CHOYP_INPP5B.1.1 m.8681 sp OCRL_MOUSE 47.493 678 340 4 285 950 215 888 0 677 OCRL_MOUSE reviewed Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) Ocrl Mus musculus (Mouse) 900 cilium assembly [GO:0042384]; in utero embryonic development [GO:0001701]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165] GO:0001701; GO:0001750; GO:0004439; GO:0005096; GO:0005634; GO:0005737; GO:0005769; GO:0005794; GO:0005802; GO:0005886; GO:0005905; GO:0007165; GO:0030136; GO:0030670; GO:0031901; GO:0042384; GO:0043087; GO:0046856; GO:0048365; GO:0052745; GO:0070062 0 0 0 PF03372;PF16726;PF00620; Q6NVM2 CHOYP_BRAFLDRAFT_128944.1.2 m.19981 sp KTNB1_XENTR 48.458 681 296 13 2 657 5 655 0 654 KTNB1_XENTR reviewed Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) katnb1 TEgg076g13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 655 cell division [GO:0051301]; microtubule severing [GO:0051013]; mitotic nuclear division [GO:0007067] GO:0000922; GO:0005813; GO:0005874; GO:0007067; GO:0008352; GO:0051013; GO:0051301 0 0 0 PF13925;PF00400; Q6NVR9 CHOYP_LOC101065695.1.1 m.13611 sp ATAD3_XENTR 69.312 567 173 1 1 566 1 567 0 806 ATAD3_XENTR reviewed ATPase family AAA domain-containing protein 3 atad3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 594 0 GO:0005524; GO:0005743; GO:0016021; GO:0042645 0 0 0 PF00004;PF12037; Q6NX31 CHOYP_MCM7.1.1 m.50070 sp MCM7_XENTR 78.771 716 150 1 3 718 2 715 0 1140 MCM7_XENTR reviewed DNA replication licensing factor mcm7 (EC 3.6.4.12) (CDC47 homolog) (Minichromosome maintenance protein 7) mcm7 TGas137h09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 720 cell cycle [GO:0007049]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000785; GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0006268; GO:0006270; GO:0007049; GO:0030174; GO:0042555; GO:0046872 0 0 0 PF00493;PF14551; Q6NY89 CHOYP_LSG1.1.1 m.14762 sp LSG1_DANRE 51.543 648 286 9 1 632 1 636 0 630 LSG1_DANRE reviewed Large subunit GTPase 1 homolog (EC 3.6.1.-) lsg1 zgc:76988 Danio rerio (Zebrafish) (Brachydanio rerio) 640 nuclear export [GO:0051168]; protein transport [GO:0015031]; ribosome biogenesis [GO:0042254] GO:0003924; GO:0005525; GO:0005783; GO:0005829; GO:0015030; GO:0015031; GO:0042254; GO:0051168 0 0 0 PF01926; Q6NYB4 CHOYP_LOC661084.1.1 m.43875 sp MB211_DANRE 76.88 359 83 0 10 368 1 359 0 600 MB211_DANRE reviewed Protein mab-21-like 1 mab21l1 Danio rerio (Zebrafish) (Brachydanio rerio) 359 multicellular organism development [GO:0007275] GO:0005634; GO:0007275 0 0 0 PF03281; Q6NYH1 CHOYP_IF122.1.2 m.50510 sp IF122_DANRE 65.164 488 109 3 1 488 1 427 0 659 IF122_DANRE reviewed Intraflagellar transport protein 122 homolog ift122 zgc:77217 Danio rerio (Zebrafish) (Brachydanio rerio) 1187 camera-type eye morphogenesis [GO:0048593]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; embryonic body morphogenesis [GO:0010172]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; negative regulation of smoothened signaling pathway [GO:0045879]; protein localization to cilium [GO:0061512]; regulation of smoothened signaling pathway [GO:0008589]; renal system development [GO:0072001] GO:0005737; GO:0005856; GO:0005929; GO:0007507; GO:0008589; GO:0010172; GO:0030991; GO:0035721; GO:0042384; GO:0045879; GO:0048593; GO:0060271; GO:0061512; GO:0072001; GO:0072372 0 0 0 PF00400; Q6NYL3 CHOYP_EHHADH.1.1 m.26459 sp ECHP_DANRE 45.927 712 374 6 6 713 7 711 0 660 ECHP_DANRE reviewed "Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase (EC 4.2.1.17) (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)]" ehhadh echd si:dkeyp-30d5.2 zgc:77526 Danio rerio (Zebrafish) (Brachydanio rerio) 718 fatty acid beta-oxidation [GO:0006635] GO:0003857; GO:0004165; GO:0004300; GO:0005777; GO:0006635 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00725;PF02737;PF00378; Q6NYU2 CHOYP_HELZ.2.2 m.43303 sp HELZ_DANRE 48.476 984 469 15 187 1143 133 1105 0 962 HELZ_DANRE reviewed Probable helicase with zinc finger domain (EC 3.6.4.-) helz zgc:77407 Danio rerio (Zebrafish) (Brachydanio rerio) 1860 0 GO:0003677; GO:0003700; GO:0004386; GO:0005524; GO:0005634; GO:0046872 0 0 0 PF00642; Q6NZ07 CHOYP_BRAFLDRAFT_84005.1.1 m.16821 sp NCLN_DANRE 52.807 570 244 6 5 554 4 568 0 598 NCLN_DANRE reviewed Nicalin-1 (Nicastrin-like protein 1) ncl1 Danio rerio (Zebrafish) (Brachydanio rerio) 572 multicellular organism development [GO:0007275]; negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900176]; regulation of signal transduction [GO:0009966] GO:0005789; GO:0005886; GO:0007275; GO:0009966; GO:0016021; GO:1900176 0 0 0 PF04389; Q6NZC7 CHOYP_SEC23IP.1.1 m.41425 sp S23IP_MOUSE 44.301 1009 452 24 26 956 20 996 0 763 S23IP_MOUSE reviewed SEC23-interacting protein Sec23ip Mus musculus (Mouse) 998 acrosome assembly [GO:0001675]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; single fertilization [GO:0007338]; spermatid development [GO:0007286] GO:0001675; GO:0004620; GO:0005801; GO:0006888; GO:0007030; GO:0007286; GO:0007338; GO:0012507; GO:0030134; GO:0044822; GO:0046872; GO:0048471; GO:0070971; GO:0097038 0 0 0 PF02862;PF00536; Q6NZJ6 CHOYP_EIF4G3.1.1 m.64769 sp IF4G1_MOUSE 41.968 1077 513 29 362 1359 382 1425 0 667 IF4G1_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) Eif4g1 Mus musculus (Mouse) 1600 behavioral fear response [GO:0001662]; positive regulation of neuron differentiation [GO:0045666]; regulation of translational initiation [GO:0006446] GO:0001662; GO:0003743; GO:0005737; GO:0006446; GO:0008190; GO:0016020; GO:0044822; GO:0045666 0 0 0 PF02847;PF02854;PF02020; Q6NZQ2 CHOYP_DDX31.1.1 m.14028 sp DDX31_MOUSE 47.792 634 287 11 77 673 17 643 0 581 DDX31_MOUSE reviewed Probable ATP-dependent RNA helicase DDX31 (EC 3.6.4.13) (DEAD box protein 31) Ddx31 Mus musculus (Mouse) 687 ribosome biogenesis [GO:0042254]; RNA secondary structure unwinding [GO:0010501] GO:0004004; GO:0005524; GO:0005730; GO:0005794; GO:0010501; GO:0042254; GO:0043231; GO:0044822 0 0 0 PF00270;PF13959;PF00271; Q6NZS4 CHOYP_RTCB.1.2 m.27510 sp RTCB_DANRE 85.885 503 71 0 28 530 3 505 0 911 RTCB_DANRE reviewed tRNA-splicing ligase RtcB homolog (EC 6.5.1.3) rtcb zgc:76871 Danio rerio (Zebrafish) (Brachydanio rerio) 505 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0003972; GO:0005524; GO:0005634; GO:0005737; GO:0006388; GO:0046872; GO:0072669 0 0 0 PF01139; Q6P0B1 CHOYP_CELF2.2.4 m.22506 sp CELF2_DANRE 57.336 518 153 14 14 492 26 514 0 524 CELF2_DANRE reviewed CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (RNA-binding protein BRUNOL-3) celf2 cugbp2 etr3 Danio rerio (Zebrafish) (Brachydanio rerio) 514 mRNA processing [GO:0006397] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006397 0 0 0 PF00076; Q6P158 CHOYP_DHX57.1.2 m.16778 sp DHX57_HUMAN 50.517 1354 577 21 70 1385 88 1386 0 1288 DHX57_HUMAN reviewed Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) DHX57 Homo sapiens (Human) 1386 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005739; GO:0006396; GO:0044822; GO:0046872 0 0 0 PF00270;PF04408;PF00271;PF07717;PF05773;PF00642; Q6P1C6 CHOYP_LRIG3.2.3 m.35347 sp LRIG3_MOUSE 44.118 884 437 16 26 897 44 882 0 695 LRIG3_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) Lrig3 Kiaa3016 Mus musculus (Mouse) 1117 otolith morphogenesis [GO:0032474] GO:0005615; GO:0005886; GO:0016021; GO:0030659; GO:0032474 0 0 0 PF07679;PF13855; Q6P1M0 CHOYP_S27A4.2.2 m.14401 sp S27A4_HUMAN 49.287 631 314 3 40 664 13 643 0 663 S27A4_HUMAN reviewed Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4) SLC27A4 ACSVL4 FATP4 Homo sapiens (Human) 643 fatty acid transport [GO:0015908]; lipid metabolic process [GO:0006629]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; response to nutrient [GO:0007584]; skin development [GO:0043588]; transport [GO:0006810]; very long-chain fatty acid catabolic process [GO:0042760] GO:0000166; GO:0001579; GO:0001676; GO:0004467; GO:0005789; GO:0005886; GO:0005902; GO:0006629; GO:0006810; GO:0007584; GO:0015245; GO:0015908; GO:0015909; GO:0016020; GO:0016021; GO:0031526; GO:0031957; GO:0042760; GO:0043588; GO:0044539 0 0 0 PF00501;PF13193; Q6P1S4 CHOYP_SYRC.2.2 m.40437 sp SYRC_XENTR 70.024 417 124 1 245 660 244 660 0 621 SYRC_XENTR reviewed "Arginine--tRNA ligase, cytoplasmic (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" rars Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 660 arginyl-tRNA aminoacylation [GO:0006420] GO:0004814; GO:0005524; GO:0005737; GO:0006420 0 0 0 PF03485;PF05746;PF00750; Q6P286 CHOYP_DHTK1.1.1 m.8426 sp DHTK1_XENLA 54.328 751 303 10 26 751 26 761 0 835 DHTK1_XENLA reviewed "Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial (EC 1.2.4.2) (Dehydrogenase E1 and transketolase domain-containing protein 1)" dhtkd1 Xenopus laevis (African clawed frog) 927 glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099] GO:0004591; GO:0005739; GO:0006096; GO:0006099; GO:0030976 0 0 0 PF00676;PF16870;PF02779; Q6P2U9 CHOYP_CSN3.1.1 m.10996 sp CSN3_DANRE 69.951 406 122 0 6 411 1 406 0 612 CSN3_DANRE reviewed COP9 signalosome complex subunit 3 (Signalosome subunit 3) cops3 csn3 wu:fc32a02 Danio rerio (Zebrafish) (Brachydanio rerio) 423 cullin deneddylation [GO:0010388]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005737; GO:0006511; GO:0008180; GO:0010388 0 0 0 PF01399; Q6P2Y2 CHOYP_BRAFLDRAFT_287844.1.1 m.63253 sp DAW1_XENTR 77.404 416 89 1 1 416 1 411 0 692 DAW1_XENTR reviewed Dynein assembly factor with WDR repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69) daw1 wdr69 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 415 0 GO:0005929 0 0 0 PF00400; Q6P3W7 CHOYP_SCYL2.1.1 m.6216 sp SCYL2_HUMAN 44.67 985 427 19 6 941 14 929 0 803 SCYL2_HUMAN reviewed SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) SCYL2 CVAK104 KIAA1360 Homo sapiens (Human) 929 endosome to lysosome transport [GO:0008333]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of clathrin-mediated endocytosis [GO:2000370]; positive regulation of receptor internalization [GO:0002092]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286] GO:0002092; GO:0004672; GO:0005102; GO:0005524; GO:0005794; GO:0008333; GO:0010008; GO:0030136; GO:0048471; GO:0090090; GO:2000286; GO:2000370 0 0 0 PF00069; Q6P423 CHOYP_MED23.1.1 m.13417 sp MED23_XENLA 57.972 1361 545 14 6 1351 1 1349 0 1580 MED23_XENLA reviewed Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) med23 Xenopus laevis (African clawed frog) 1369 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11573; Q6P4S6 CHOYP_SIK3.1.1 m.8214 sp SIK3_MOUSE 51.083 785 298 20 17 785 3 717 0 681 SIK3_MOUSE reviewed Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) Sik3 Kiaa0999 Qsk Mus musculus (Mouse) 1311 cartilage development involved in endochondral bone morphogenesis [GO:0060351]; endochondral ossification [GO:0001958]; limb morphogenesis [GO:0035108]; multicellular organism growth [GO:0035264]; protein phosphorylation [GO:0006468]; regulation of protein localization [GO:0032880]; skeletal system morphogenesis [GO:0048705] GO:0000287; GO:0001958; GO:0004674; GO:0005524; GO:0005737; GO:0006468; GO:0032880; GO:0035108; GO:0035264; GO:0048705; GO:0060351 0 0 0 PF00069; Q6P4S8 CHOYP_INT1.1.1 m.19029 sp INT1_MOUSE 51.603 655 294 11 13 651 23 670 0 668 INT1_MOUSE reviewed Integrator complex subunit 1 (Int1) Ints1 Mus musculus (Mouse) 2195 blastocyst growth [GO:0001832]; inner cell mass cell proliferation [GO:0001833]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; snRNA processing [GO:0016180]; U2 snRNA 3'-end processing [GO:0034474] GO:0001832; GO:0001833; GO:0005634; GO:0016020; GO:0016021; GO:0016180; GO:0031965; GO:0032039; GO:0034474; GO:0043066; GO:0043154 0 0 0 PF12432; Q6P4S8 CHOYP_LOC100655005.1.1 m.51334 sp INT1_MOUSE 51.875 1307 574 19 35 1298 23 1317 0 1283 INT1_MOUSE reviewed Integrator complex subunit 1 (Int1) Ints1 Mus musculus (Mouse) 2195 blastocyst growth [GO:0001832]; inner cell mass cell proliferation [GO:0001833]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; snRNA processing [GO:0016180]; U2 snRNA 3'-end processing [GO:0034474] GO:0001832; GO:0001833; GO:0005634; GO:0016020; GO:0016021; GO:0016180; GO:0031965; GO:0032039; GO:0034474; GO:0043066; GO:0043154 0 0 0 PF12432; Q6P4W8 CHOYP_PCH2.1.1 m.7113 sp PCH2_XENTR 63.194 432 156 3 1 430 1 431 0 561 PCH2_XENTR reviewed Pachytene checkpoint protein 2 homolog (Thyroid hormone receptor interactor 13 homolog) (Thyroid receptor-interacting protein 13 homolog) (TR-interacting protein 13 homolog) (TRIP-13 homolog) trip13 pch2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 432 double-strand break repair [GO:0006302]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] GO:0005524; GO:0006302; GO:0007130; GO:0007131; GO:0007283; GO:0048477 0 0 0 PF00004; Q6P4Y0 CHOYP_CDKAL.1.1 m.13548 sp CDKAL_XENTR 68.431 548 161 2 1 536 1 548 0 793 CDKAL_XENTR reviewed Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) cdkal1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 553 0 GO:0005783; GO:0005789; GO:0016021; GO:0035598; GO:0046872; GO:0051539; GO:0061712 0 0 0 PF04055;PF01938;PF00919; Q6P5B0 CHOYP_LOC100377837.2.2 m.7996 sp RRP12_MOUSE 47.458 1298 636 13 17 1289 13 1289 0 1120 RRP12_MOUSE reviewed RRP12-like protein Rrp12 Kiaa0690 Mus musculus (Mouse) 1295 0 GO:0005730; GO:0016021; GO:0031965; GO:0044822 0 0 0 PF08161; Q6P5D8 CHOYP_SMHD1.1.1 m.47344 sp SMHD1_MOUSE 46.007 1991 1023 27 21 1983 28 1994 0 1822 SMHD1_MOUSE reviewed Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Smchd1 Kiaa0650 Mus musculus (Mouse) 2007 chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; inactivation of X chromosome by DNA methylation [GO:0060821] GO:0000781; GO:0001740; GO:0005524; GO:0009048; GO:0051276; GO:0060821 0 0 0 PF06470; Q6P5E8 CHOYP_LOC100900935.1.1 m.56691 sp DGKQ_MOUSE 41.542 934 475 16 28 951 42 914 0 724 DGKQ_MOUSE reviewed Diacylglycerol kinase theta (DAG kinase theta) (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) Dgkq Mus musculus (Mouse) 934 cAMP-mediated signaling [GO:0019933]; G-protein coupled receptor signaling pathway [GO:0007186]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein kinase C signaling [GO:0070528]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to ATP [GO:0033198]; thrombin receptor signaling pathway [GO:0070493] GO:0004143; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006357; GO:0007186; GO:0007205; GO:0016607; GO:0019900; GO:0019933; GO:0033198; GO:0033613; GO:0043274; GO:0046872; GO:0070493; GO:0070528 0 0 0 PF00130;PF00609;PF00781;PF00788; Q6P6Y1 CHOYP_K1468.1.1 m.24917 sp K1468_DANRE 47.27 1172 541 15 22 1158 60 1189 0 1017 K1468_DANRE reviewed LisH domain and HEAT repeat-containing protein KIAA1468 homolog zgc:66014 Danio rerio (Zebrafish) (Brachydanio rerio) 1189 0 0 0 0 0 0 Q6P799 CHOYP_LOC656867.1.1 m.28658 sp SYSC_RAT 70 500 148 2 1 499 1 499 0 739 SYSC_RAT reviewed "Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" Sars Sars1 Rattus norvegicus (Rat) 512 selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; seryl-tRNA aminoacylation [GO:0006434] GO:0004828; GO:0005524; GO:0005737; GO:0006434; GO:0097056 PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. 0 cd00770; PF02403;PF00587; Q6P7A9 CHOYP_LOC100553663.1.1 m.58460 sp LYAG_RAT 47.845 905 432 12 69 954 69 952 0 892 LYAG_RAT reviewed Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Gaa Rattus norvegicus (Rat) 953 glycogen catabolic process [GO:0005980] GO:0004558; GO:0005764; GO:0005765; GO:0005980; GO:0030246; GO:0032450 0 0 cd00111; PF13802;PF01055;PF16863;PF00088; Q6P8G1 CHOYP_BRAFLDRAFT_76728.1.1 m.17486 sp ILF2_XENTR 71.229 358 101 2 51 407 18 374 0 541 ILF2_XENTR reviewed Interleukin enhancer-binding factor 2 homolog ilf2 TEgg021l09.1 TEgg033l23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 388 "immune response [GO:0006955]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003725; GO:0005524; GO:0005634; GO:0005730; GO:0006351; GO:0006955; GO:0016740; GO:0045893 0 0 0 PF07528; Q6P9I7 CHOYP_BRAFLDRAFT_131216.1.1 m.8822 sp SMC6_XENLA 41.289 1102 626 9 10 1100 35 1126 0 840 SMC6_XENLA reviewed Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (xSMC6) smc6 smc6l1 Xenopus laevis (African clawed frog) 1128 cellular senescence [GO:0090398]; double-strand break repair via homologous recombination [GO:0000724]; resolution of recombination intermediates [GO:0071139]; telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000724; GO:0000781; GO:0005524; GO:0016605; GO:0030915; GO:0071139; GO:0090398 0 0 0 PF02463; Q6PAY8 CHOYP_NEMVEDRAFT_V1G173950.1.1 m.13512 sp HSDL2_XENLA 61.962 418 151 5 1 414 1 414 0 518 HSDL2_XENLA reviewed Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) hsdl2 Xenopus laevis (African clawed frog) 417 0 GO:0005777; GO:0016491 0 0 0 PF00106;PF02036; Q6PB44 CHOYP_PTPN23.1.1 m.16408 sp PTN23_MOUSE 47.838 717 360 7 26 733 1 712 0 720 PTN23_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) Ptpn23 Kiaa1471 Mus musculus (Mouse) 1692 cilium morphogenesis [GO:0060271]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0010633; GO:0015031; GO:0016023; GO:0019901; GO:0036064; GO:0043162; GO:0060271; GO:0070062; GO:1903387; GO:1903393; GO:2000643 0 0 0 PF13949;PF03097;PF00102; Q6PBT5 CHOYP_PYRD1.1.1 m.12691 sp PYRD1_DANRE 58.403 476 188 4 4 476 13 481 0 590 PYRD1_DANRE reviewed Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-) pyroxd1 zgc:73254 Danio rerio (Zebrafish) (Brachydanio rerio) 490 0 GO:0016491 0 0 0 PF07992; Q6PBY7 CHOYP_BRAFLDRAFT_282065.2.2 m.49972 sp TPC13_DANRE 63.5 400 142 3 22 420 7 403 0 516 TPC13_DANRE reviewed Trafficking protein particle complex subunit 13 trappc13 zgc:73187 Danio rerio (Zebrafish) (Brachydanio rerio) 412 0 0 0 0 0 PF06159; Q6PC30 CHOYP_CSN5.1.1 m.52330 sp CSN5_DANRE 83.891 329 53 0 22 350 4 332 0 575 CSN5_DANRE reviewed COP9 signalosome complex subunit 5 (Signalosome subunit 5) (EC 3.4.-.-) cops5 zgc:73130 Danio rerio (Zebrafish) (Brachydanio rerio) 334 0 GO:0008180; GO:0008237; GO:0046872; GO:0048471 0 0 0 PF01398; Q6PCL9 CHOYP_LOC101061332.1.1 m.25069 sp PAPOG_MOUSE 60.342 527 199 7 5 527 17 537 0 663 PAPOG_MOUSE reviewed Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) Papolg Mus musculus (Mouse) 739 mRNA polyadenylation [GO:0006378]; RNA polyadenylation [GO:0043631] GO:0003723; GO:0004652; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006378; GO:0016020; GO:0043631; GO:0046872 0 0 0 PF01909;PF04928;PF04926; Q6PCL9 CHOYP_PAPOG.1.2 m.33182 sp PAPOG_MOUSE 49.266 749 334 19 5 735 17 737 0 672 PAPOG_MOUSE reviewed Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) Papolg Mus musculus (Mouse) 739 mRNA polyadenylation [GO:0006378]; RNA polyadenylation [GO:0043631] GO:0003723; GO:0004652; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006378; GO:0016020; GO:0043631; GO:0046872 0 0 0 PF01909;PF04928;PF04926; Q6PCM2 CHOYP_INT6.1.1 m.13005 sp INT6_MOUSE 51.648 910 344 16 1 858 1 866 0 866 INT6_MOUSE reviewed Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) Ints6 Dbi1 Ddx26 Mus musculus (Mouse) 883 snRNA processing [GO:0016180] GO:0005654; GO:0015629; GO:0016180; GO:0032039 0 0 0 PF15300;PF13519; Q6PCR7 CHOYP_MROH1.1.1 m.24367 sp EIF3A_DANRE 56.033 1094 407 15 1 1038 1 1076 0 1043 EIF3A_DANRE reviewed Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) eif3a eif3s10 Danio rerio (Zebrafish) (Brachydanio rerio) 1267 formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446] GO:0001731; GO:0001732; GO:0003743; GO:0005852; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF01399; Q6PCX9 CHOYP_HS90A.3.3 m.28298 sp TRI37_MOUSE 72.345 452 123 2 12 463 1 450 0 722 TRI37_MOUSE reviewed E3 ubiquitin-protein ligase TRIM37 (EC 6.3.2.-) (Tripartite motif-containing protein 37) Trim37 Kiaa0898 Mus musculus (Mouse) 961 aggresome assembly [GO:0070842]; histone H2A-K119 monoubiquitination [GO:0036353]; histone H2A monoubiquitination [GO:0035518]; negative regulation of centriole replication [GO:0046600]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein autoubiquitination [GO:0051865] GO:0000122; GO:0003682; GO:0004842; GO:0005164; GO:0005737; GO:0005777; GO:0005829; GO:0008270; GO:0016235; GO:0016874; GO:0031625; GO:0032088; GO:0035098; GO:0035518; GO:0036353; GO:0042803; GO:0046600; GO:0048471; GO:0051091; GO:0051092; GO:0051865; GO:0061630; GO:0070842 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25470042}. 0 0 PF00917;PF00643; Q6PCX9 CHOYP_TRIM37.1.1 m.44170 sp TRI37_MOUSE 73.198 444 117 2 1 444 9 450 0 699 TRI37_MOUSE reviewed E3 ubiquitin-protein ligase TRIM37 (EC 6.3.2.-) (Tripartite motif-containing protein 37) Trim37 Kiaa0898 Mus musculus (Mouse) 961 aggresome assembly [GO:0070842]; histone H2A-K119 monoubiquitination [GO:0036353]; histone H2A monoubiquitination [GO:0035518]; negative regulation of centriole replication [GO:0046600]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein autoubiquitination [GO:0051865] GO:0000122; GO:0003682; GO:0004842; GO:0005164; GO:0005737; GO:0005777; GO:0005829; GO:0008270; GO:0016235; GO:0016874; GO:0031625; GO:0032088; GO:0035098; GO:0035518; GO:0036353; GO:0042803; GO:0046600; GO:0048471; GO:0051091; GO:0051092; GO:0051865; GO:0061630; GO:0070842 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25470042}. 0 0 PF00917;PF00643; Q6PD03 CHOYP_LOC100741406.1.1 m.29038 sp 2A5A_MOUSE 78.414 454 96 2 7 458 19 472 0 731 2A5A_MOUSE reviewed Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha) Ppp2r5a Mus musculus (Mouse) 486 beta-catenin destruction complex disassembly [GO:1904886]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of lipid kinase activity [GO:0090219]; positive regulation of protein dephosphorylation [GO:0035307] GO:0000159; GO:0000775; GO:0005634; GO:0005737; GO:0005829; GO:0008601; GO:0016020; GO:0019900; GO:0030018; GO:0031430; GO:0035307; GO:0090005; GO:0090219; GO:1904886 0 0 0 PF01603; Q6PD24 CHOYP_AN13B.1.1 m.15287 sp AN13D_MOUSE 54.366 607 253 10 10 602 8 604 0 647 AN13D_MOUSE reviewed Ankyrin repeat domain-containing protein 13D Ankrd13d Mus musculus (Mouse) 605 0 GO:0005770; GO:0005886 0 0 0 PF12796;PF11904; Q6PDI5 CHOYP_ECM29.1.1 m.48083 sp ECM29_MOUSE 48.763 1819 853 25 11 1777 3 1794 0 1730 ECM29_MOUSE reviewed Proteasome-associated protein ECM29 homolog (Ecm29) Ecm29 Kiaa0368 Mus musculus (Mouse) 1840 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; proteasome assembly [GO:0043248] GO:0000502; GO:0005634; GO:0005769; GO:0005770; GO:0005771; GO:0005783; GO:0005793; GO:0005813; GO:0016020; GO:0016023; GO:0030134; GO:0030139; GO:0030433; GO:0043248 0 0 0 PF13001; Q6PEI7 CHOYP_PYRG1.1.1 m.13552 sp PYRG1_DANRE 69.36 594 175 5 1 590 1 591 0 875 PYRG1_DANRE reviewed CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1) ctps1 ctps1a ctpsa Danio rerio (Zebrafish) (Brachydanio rerio) 591 'de novo' CTP biosynthetic process [GO:0044210]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541] GO:0003883; GO:0005524; GO:0006241; GO:0006541; GO:0044210 PATHWAY: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. {ECO:0000250|UniProtKB:P17812}. 0 0 PF06418;PF00117; Q6PFM0 CHOYP_LOC100370709.1.1 m.11224 sp JMJD6_DANRE 65.385 390 129 3 1 388 1 386 0 521 JMJD6_DANRE reviewed Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) (zfpsr) jmjd6 psr ptdsr zgc:66264 Danio rerio (Zebrafish) (Brachydanio rerio) 403 "cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine [GO:0018395]; phagocytosis [GO:0006909]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; sprouting angiogenesis [GO:0002040]; transcription, DNA-templated [GO:0006351]" GO:0002040; GO:0003727; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0006397; GO:0006909; GO:0008380; GO:0018395; GO:0030154; GO:0033746; GO:0033749; GO:0046872; GO:0048024; GO:0070815 0 0 0 PF02373; Q6PFQ2 CHOYP_EIF3C.1.1 m.7991 sp EIF3C_DANRE 56.263 926 352 11 1 875 1 924 0 979 EIF3C_DANRE reviewed Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) eif3c eif3s8 Danio rerio (Zebrafish) (Brachydanio rerio) 926 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0003743; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0031369; GO:0033290 0 0 0 PF05470;PF01399; Q6PGW3 CHOYP_ISCW_ISCW018656.1.1 m.51893 sp CJ076_DANRE 55.78 692 283 5 9 688 1 681 0 789 CJ076_DANRE reviewed UPF0668 protein C10orf76 homolog zgc:63733 Danio rerio (Zebrafish) (Brachydanio rerio) 689 0 GO:0016021 0 0 0 PF08427; Q6PHS6 CHOYP_BRAFLDRAFT_67769.1.1 m.9410 sp SNX13_MOUSE 41.365 967 505 17 8 935 10 953 0 742 SNX13_MOUSE reviewed Sorting nexin-13 Snx13 Mus musculus (Mouse) 957 intracellular protein transport [GO:0006886]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547] GO:0005769; GO:0006886; GO:0009968; GO:0031901; GO:0032266; GO:0035091; GO:0043547 0 0 0 PF08628;PF00787;PF02194;PF00615; Q6PIW4 CHOYP_LOC578480.1.1 m.16062 sp FIGL1_HUMAN 49.138 696 303 14 12 690 11 672 0 596 FIGL1_HUMAN reviewed Fidgetin-like protein 1 (EC 3.6.4.-) FIGNL1 Homo sapiens (Human) 674 ATP metabolic process [GO:0046034]; cellular response to ionizing radiation [GO:0071479]; cytoplasmic microtubule organization [GO:0031122]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; osteoblast differentiation [GO:0001649]; osteoblast proliferation [GO:0033687]; regulation of cell cycle [GO:0051726]; regulation of double-strand break repair via homologous recombination [GO:0010569] GO:0000228; GO:0000287; GO:0001649; GO:0005524; GO:0005634; GO:0005737; GO:0008568; GO:0010569; GO:0016787; GO:0031122; GO:0033687; GO:0043066; GO:0046034; GO:0051726; GO:0070062; GO:0071479; GO:2001243 0 0 0 PF00004;PF09336; Q6Q0C0 CHOYP_SMC2.1.4 m.17837 sp TRAF7_HUMAN 58.081 594 236 6 97 684 82 668 0 733 TRAF7_HUMAN reviewed E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) 670 "activation of MAPKKK activity [GO:0000185]; apoptotic process [GO:0006915]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000185; GO:0004842; GO:0005886; GO:0006351; GO:0006355; GO:0006915; GO:0008270; GO:0016023; GO:0016567; GO:0016874; GO:0043231; GO:0043410; GO:2001235 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400;PF13445; Q6Q0C0 CHOYP_TRAF7.1.1 m.18344 sp TRAF7_HUMAN 57.744 594 238 6 97 684 82 668 0 727 TRAF7_HUMAN reviewed E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (TNF receptor-associated factor 7) TRAF7 RFWD1 RNF119 Homo sapiens (Human) 670 "activation of MAPKKK activity [GO:0000185]; apoptotic process [GO:0006915]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000185; GO:0004842; GO:0005886; GO:0006351; GO:0006355; GO:0006915; GO:0008270; GO:0016023; GO:0016567; GO:0016874; GO:0043231; GO:0043410; GO:2001235 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400;PF13445; Q6Q4G4 CHOYP_LOC101076790.1.1 m.45316 sp ACE_THETS 49.668 602 294 5 40 636 9 606 0 634 ACE_THETS reviewed Angiotensin-converting enzyme (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (TtACE) ACE Theromyzon tessulatum (Duck leech) 616 0 GO:0004180; GO:0005615; GO:0008237; GO:0008241; GO:0016020; GO:0046872 0 0 0 PF01401; Q6Q759 CHOYP_BRAFLDRAFT_120607.1.3 m.8455 sp SPG17_HUMAN 32.548 1994 1138 48 4 1844 2 1941 0 848 SPG17_HUMAN reviewed Sperm-associated antigen 17 (Projection protein PF6 homolog) SPAG17 Homo sapiens (Human) 2223 axoneme assembly [GO:0035082]; cilium movement [GO:0003341] GO:0003341; GO:0005654; GO:0005737; GO:0005874; GO:0031514; GO:0035082; GO:1990716 0 0 0 0 Q6Q759 CHOYP_BRAFLDRAFT_120607.3.3 m.49783 sp SPG17_HUMAN 32.628 1986 1127 49 4 1824 2 1941 0 847 SPG17_HUMAN reviewed Sperm-associated antigen 17 (Projection protein PF6 homolog) SPAG17 Homo sapiens (Human) 2223 axoneme assembly [GO:0035082]; cilium movement [GO:0003341] GO:0003341; GO:0005654; GO:0005737; GO:0005874; GO:0031514; GO:0035082; GO:1990716 0 0 0 0 Q6Q760 CHOYP_LOC100883628.1.1 m.54992 sp NALCN_RAT 54.153 1782 729 22 12 1757 1 1730 0 1844 NALCN_RAT reviewed Sodium leak channel non-selective protein (Four domain-type voltage-gated ion channel alpha-1 subunit) (Rb21-channel) (Voltage gated channel-like protein 1) Nalcn Nca Rb21 Vgcnl1 Rattus norvegicus (Rat) 1738 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; ion transmembrane transport [GO:0034220]; membrane depolarization during action potential [GO:0086010]; potassium ion transmembrane transport [GO:0071805]; regulation of resting membrane potential [GO:0060075]; sodium ion transmembrane transport [GO:0035725] GO:0005244; GO:0005261; GO:0005272; GO:0005886; GO:0006816; GO:0016021; GO:0022840; GO:0034220; GO:0035725; GO:0060075; GO:0070588; GO:0071805; GO:0086010 0 0 0 PF00520; Q6QM28 CHOYP_LOC100533225.1.2 m.36896 sp SYN_HELPO 55.05 505 197 5 1 484 1 496 0 530 SYN_HELPO reviewed Synapsin (helSyn) SYN Helix pomatia (Roman snail) (Edible snail) 496 neurotransmitter secretion [GO:0007269] GO:0003824; GO:0005524; GO:0007269; GO:0008021; GO:0030054; GO:0042995; GO:0046872 0 0 0 PF02078;PF02750; Q6R327 CHOYP_LOC100367446.1.1 m.17295 sp RICTR_HUMAN 37.048 1768 962 37 1 1693 2 1693 0 993 RICTR_HUMAN reviewed Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) RICTOR KIAA1999 Homo sapiens (Human) 1708 actin cytoskeleton reorganization [GO:0031532]; embryo development [GO:0009790]; establishment of cell polarity [GO:0030010]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of GTPase activity [GO:0043087]; regulation of inflammatory response [GO:0050727]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of phosphorylation [GO:0042325]; regulation of protein kinase B signaling [GO:0051896]; T cell costimulation [GO:0031295]; TOR signaling [GO:0031929] GO:0001938; GO:0005829; GO:0008047; GO:0009790; GO:0010468; GO:0018105; GO:0019901; GO:0030010; GO:0030838; GO:0030950; GO:0031295; GO:0031532; GO:0031929; GO:0031932; GO:0032008; GO:0032956; GO:0033135; GO:0042325; GO:0043022; GO:0043087; GO:0048015; GO:0050727; GO:0050731; GO:0051896; GO:0051897; GO:2000114 0 0 0 PF14663;PF14666;PF14664;PF14665;PF14668; Q6R7A1 CHOYP_Y124.1.1 m.28503 sp Y122_OSHVF 98.438 384 6 0 1 384 1 384 0 770 Y122_OSHVF reviewed Uncharacterized protein ORF122 ORF122 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 384 0 0 0 0 0 0 Q6R7A2 CHOYP_Y124.1.1 m.28502 sp Y124_OSHVF 98.734 474 6 0 1 474 1 474 0 981 Y124_OSHVF reviewed Uncharacterized protein ORF124 ORF124 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 474 0 0 0 0 0 0 Q6R7B5 CHOYP_Y004.1.1 m.30756 sp Y004_OSHVF 99.713 349 1 0 1 349 1 349 0 726 Y004_OSHVF reviewed Uncharacterized protein ORF4 ORF4 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 349 0 0 0 0 0 0 Q6R7B7 CHOYP_Y112.1.1 m.30495 sp Y113_OSHVF 99.371 318 2 0 1 318 1 318 0 645 Y113_OSHVF reviewed Uncharacterized protein ORF113 ORF113 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 318 0 0 0 0 0 0 Q6R7B8 CHOYP_Y112.1.1 m.30494 sp Y112_OSHVF 99.567 462 2 0 1 462 1 462 0 959 Y112_OSHVF reviewed Uncharacterized protein ORF112 ORF112 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 462 0 0 0 0 0 0 Q6R7B9 CHOYP_Y112.1.1 m.30496 sp Y111_OSHVF 100 289 0 0 1 289 1 289 0 594 Y111_OSHVF reviewed Putative transmembrane protein ORF111 ORF110 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 289 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7C0 CHOYP_Y104.1.1 m.27144 sp Y110_OSHVF 100 258 0 0 1 258 1 258 0 529 Y110_OSHVF reviewed Uncharacterized protein ORF110 ORF110 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 261 0 0 0 0 0 0 Q6R7C1 CHOYP_Y104.1.1 m.27137 sp Y109_OSHVF 100 874 0 0 1 874 1 874 0 1814 Y109_OSHVF reviewed Uncharacterized protein ORF109 ORF109 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 874 DNA packaging [GO:0006323] GO:0006323 0 0 0 PF02499;PF02500; Q6R7C2 CHOYP_Y104.1.1 m.27142 sp Y108_OSHVF 98.889 270 3 0 1 270 1 270 0 547 Y108_OSHVF reviewed Uncharacterized protein ORF108 ORF108 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 270 0 0 0 0 0 0 Q6R7C3 CHOYP_Y104.1.1 m.27139 sp Y107_OSHVF 98.984 689 7 0 1 689 1 689 0 1400 Y107_OSHVF reviewed Uncharacterized protein ORF107 ORF107 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 689 0 0 0 0 0 0 Q6R7C4 CHOYP_Y104.1.1 m.27140 sp IAP4_OSHVF 98.507 469 3 1 1 469 1 465 0 953 IAP4_OSHVF reviewed Putative apoptosis inhibitor ORF106 ORF106 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 465 0 GO:0008270 0 0 0 PF00653; Q6R7C5 CHOYP_Y104.1.1 m.27136 sp Y104_OSHVF 99.502 1204 5 1 1 1204 1 1203 0 2465 Y104_OSHVF reviewed Uncharacterized protein ORF104 ORF104 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1203 0 0 0 0 0 0 Q6R7C6 CHOYP_Y104.1.1 m.27141 sp Y103_OSHVF 99.291 423 3 0 1 423 1 423 0 863 Y103_OSHVF reviewed Putative transmembrane protein ORF103 ORF103 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 423 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7C7 CHOYP_Y104.1.1 m.27138 sp Y102_OSHVF 99.344 762 4 1 1 761 1 762 0 1574 Y102_OSHVF reviewed Uncharacterized protein ORF102 ORF102 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 762 0 0 0 0 0 0 Q6R7C9 CHOYP_DPOL.1.1 m.30089 sp DPOL_OSHVF 99.414 1878 11 0 1 1878 1 1878 0 3899 DPOL_OSHVF reviewed DNA polymerase (EC 2.7.7.7) ORF100 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1878 DNA replication [GO:0006260] GO:0000166; GO:0003677; GO:0003887; GO:0006260; GO:0008408 0 0 0 PF00136;PF03104; Q6R7D1 CHOYP_Y098.1.1 m.30134 sp Y098_OSHVF 99.027 514 5 0 1 514 67 580 0 1062 Y098_OSHVF reviewed Uncharacterized protein ORF98 ORF98 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 584 0 0 0 0 0 0 Q6R7D4 CHOYP_Y093.1.1 m.27704 sp Y095_OSHVF 99.353 309 2 0 1 309 1 309 0 627 Y095_OSHVF reviewed Uncharacterized protein ORF95 ORF95 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 310 0 GO:0045145 0 0 0 PF09810; Q6R7D5 CHOYP_Y093.1.1 m.27703 sp Y094_OSHVF 100 347 0 0 1 347 1 347 0 726 Y094_OSHVF reviewed Uncharacterized protein ORF94 ORF94 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 347 0 0 0 0 0 0 Q6R7D6 CHOYP_Y093.1.1 m.27702 sp Y093_OSHVF 100 404 0 0 1 404 1 404 0 827 Y093_OSHVF reviewed Uncharacterized protein ORF93 ORF93 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 404 0 0 0 0 0 0 Q6R7D8 CHOYP_Y077.1.1 m.27636 sp Y091_OSHVF 100 286 0 0 1 286 75 360 0 592 Y091_OSHVF reviewed Uncharacterized protein ORF91 ORF91 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 360 0 0 0 0 0 0 Q6R7D9 CHOYP_Y077.1.1 m.27634 sp Y090_OSHVF 98.639 294 4 0 57 350 1 294 0 567 Y090_OSHVF reviewed Uncharacterized protein ORF90 ORF90 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 294 0 0 0 0 0 0 Q6R7E0 CHOYP_Y077.1.1 m.27637 sp Y089_OSHVF 100 244 0 0 1 244 1 244 0 505 Y089_OSHVF reviewed Uncharacterized protein ORF89 ORF89 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 244 0 0 0 0 0 0 Q6R7E1 CHOYP_Y077.1.1 m.27631 sp Y088_OSHVF 98.663 748 10 0 1 748 1 748 0 1507 Y088_OSHVF reviewed Putative transmembrane protein ORF88 ORF88 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 748 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7E4 CHOYP_Y077.1.1 m.27632 sp Y085_OSHVF 99.55 667 3 0 1 667 1 667 0 1357 Y085_OSHVF reviewed Uncharacterized protein ORF85 ORF85 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 667 0 0 0 0 0 0 Q6R7E6 CHOYP_Y077.1.1 m.27633 sp Y083_OSHVF 99.728 368 1 0 1 368 1 368 0 750 Y083_OSHVF reviewed Uncharacterized protein ORF83 ORF83 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 368 0 0 0 0 0 0 Q6R7E7 CHOYP_Y077.1.1 m.27635 sp Y082_OSHVF 99.662 296 1 0 1 296 1 296 0 614 Y082_OSHVF reviewed Uncharacterized protein ORF82 ORF82 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 296 0 0 0 0 0 0 Q6R7F1 CHOYP_Y077.1.1 m.27630 sp Y078_OSHVF 99.131 1151 10 0 1 1151 1 1151 0 2302 Y078_OSHVF reviewed Uncharacterized protein ORF78 ORF78 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1151 0 0 0 0 0 0 Q6R7F2 CHOYP_Y077.1.1 m.27629 sp Y077_OSHVF 99.446 1264 7 0 1 1264 1 1264 0 2608 Y077_OSHVF reviewed Uncharacterized protein ORF77 ORF77 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1264 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7F7 CHOYP_Y071.1.1 m.29246 sp Y071_OSHVF 99.779 453 1 0 1 453 1 453 0 942 Y071_OSHVF reviewed Uncharacterized protein ORF71 ORF71 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 453 0 0 0 0 0 0 Q6R7F9 CHOYP_Y068.4.6 m.30825 sp Y069_OSHVF 100 463 0 0 5 467 1 463 0 963 Y069_OSHVF reviewed Uncharacterized protein ORF69 ORF69 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 463 0 0 0 0 0 0 Q6R7G0 CHOYP_Y068.4.6 m.30824 sp Y068_OSHVF 99.856 693 0 1 1 693 1 692 0 1426 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7G3 CHOYP_OSHV1_GP060.1.1 m.28283 sp Y064_OSHVF 100 398 0 0 1 398 1 398 0 827 Y064_OSHVF reviewed Uncharacterized protein ORF64 ORF64 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 398 0 0 0 0 0 0 Q6R7G4 CHOYP_Y061.1.1 m.29896 sp Y061_OSHVF 99.654 578 2 0 1 578 1 578 0 1203 Y061_OSHVF reviewed Uncharacterized protein ORF61 ORF61 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 578 0 0 0 0 0 0 Q6R7G5 CHOYP_Y061.1.1 m.29897 sp Y060_OSHVF 99.757 411 1 0 1 411 1 411 0 842 Y060_OSHVF reviewed Uncharacterized protein ORF60 ORF60 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 411 0 0 0 0 0 0 Q6R7G6 CHOYP_Y059.1.1 m.26785 sp Y059_OSHVF 99.808 1041 2 0 1 1041 1 1041 0 2157 Y059_OSHVF reviewed Uncharacterized protein ORF59 ORF59 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1080 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7G7 CHOYP_Y058.1.1 m.27496 sp Y058_OSHVF 99.807 519 1 0 1 519 1 519 0 1071 Y058_OSHVF reviewed Uncharacterized protein ORF58 ORF58 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 521 0 0 0 0 0 0 Q6R7G8 CHOYP_Y057.1.1 m.30500 sp Y057_OSHVF 100 305 0 0 1 305 1 305 0 626 Y057_OSHVF reviewed Putative transmembrane protein ORF57 ORF57 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 316 0 GO:0016021; GO:0033644 0 0 0 PF05934; Q6R7G9 CHOYP_Y057.1.1 m.30501 sp Y056_OSHVF 100 282 0 0 1 282 1 282 0 577 Y056_OSHVF reviewed Uncharacterized protein ORF56 ORF56 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 282 0 0 0 0 0 0 Q6R7H1 CHOYP_RIR1.1.2 m.28529 sp Y054_OSHVF 99.255 805 6 0 1 805 1 805 0 1651 Y054_OSHVF reviewed Uncharacterized protein ORF54 ORF54 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 807 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7H2 CHOYP_RIR1.1.2 m.28530 sp Y053_OSHVF 99.612 515 2 0 1 515 1 515 0 1046 Y053_OSHVF reviewed Uncharacterized protein ORF53 ORF53 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 515 0 0 0 0 0 0 Q6R7H4 CHOYP_RIR1.1.2 m.28528 sp RIR1_OSHVF 99.76 835 2 0 1 835 1 835 0 1740 RIR1_OSHVF reviewed Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) 0 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 835 DNA replication [GO:0006260] GO:0004748; GO:0005524; GO:0006260 PATHWAY: Genetic information processing; DNA replication. 0 0 PF02867;PF00317; Q6R7H5 CHOYP_Y049.1.1 m.29278 sp Y049_OSHVF 99.824 1138 2 0 10 1147 1 1138 0 2365 Y049_OSHVF reviewed Uncharacterized protein ORF49 ORF49 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1138 0 0 0 0 0 0 Q6R7H7 CHOYP_Y047.1.1 m.27086 sp Y047_OSHVF 99.788 1412 3 0 1 1412 1 1412 0 2939 Y047_OSHVF reviewed Uncharacterized protein ORF47 ORF47 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1412 0 0 0 0 0 0 Q6R7I0 CHOYP_Y047.1.1 m.27087 sp Y044_OSHVF 99.675 308 1 0 1 308 1 308 0 636 Y044_OSHVF reviewed Uncharacterized protein ORF44 ORF44 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 308 0 0 0 0 0 PF01712; Q6R7I2 CHOYP_IAP1.2.4 m.30873 sp IAP1_OSHVF 99.451 364 2 0 1 364 1 364 0 758 IAP1_OSHVF reviewed Putative apoptosis inhibitor ORF42 ORF42 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 364 0 GO:0008270 0 0 0 PF00653; Q6R7I3 CHOYP_Y041.1.1 m.29176 sp Y041_OSHVF 99.383 972 6 0 1 972 1 972 0 2003 Y041_OSHVF reviewed Uncharacterized protein ORF41 ORF41 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 972 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7J3 CHOYP_Y028.1.1 m.30880 sp Y030_OSHVF 100 248 0 0 1 248 1 248 0 520 Y030_OSHVF reviewed Uncharacterized protein ORF30 ORF30 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 248 0 0 0 0 0 PF03048; Q6R7J5 CHOYP_Y028.1.1 m.30878 sp Y028_OSHVF 99.883 853 1 0 1 853 1 853 0 1749 Y028_OSHVF reviewed Uncharacterized protein ORF28 ORF28 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 853 0 0 0 0 0 0 Q6R7J6 CHOYP_Y027.1.1 m.27692 sp Y027_OSHVF 100 266 0 0 1 266 1 266 0 537 Y027_OSHVF reviewed Uncharacterized protein ORF27 ORF27 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 266 dUTP metabolic process [GO:0046080] GO:0016787; GO:0046080 0 0 0 PF00692; Q6R7J7 CHOYP_Y024.1.1 m.29966 sp Y026_OSHVF 99.494 395 2 0 1 395 1 395 0 795 Y026_OSHVF reviewed Uncharacterized protein ORF26 ORF26 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 395 0 0 0 0 0 0 Q6R7J9 CHOYP_Y024.1.1 m.29967 sp Y024_OSHVF 99.469 377 2 0 1 377 1 377 0 782 Y024_OSHVF reviewed Uncharacterized protein ORF24 ORF24 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 377 0 0 0 0 0 0 Q6R7K0 CHOYP_Y023.1.1 m.28713 sp Y023_OSHVF 98.978 1272 13 0 13 1284 1 1272 0 2573 Y023_OSHVF reviewed Uncharacterized protein ORF23 ORF23 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1272 0 0 0 0 0 0 Q6R7K1 CHOYP_Y022.1.1 m.30669 sp Y022_OSHVF 99.816 1632 3 0 1 1632 1 1632 0 3396 Y022_OSHVF reviewed Uncharacterized protein ORF22 ORF22 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1632 0 GO:0016021; GO:0033644 0 0 0 0 Q6R7K2 CHOYP_Y022.1.1 m.30670 sp Y021_OSHVF 99.187 984 8 0 1 984 1 984 0 2001 Y021_OSHVF reviewed Uncharacterized protein ORF21 ORF21 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 984 0 0 0 0 0 0 Q6R7K3 CHOYP_Y022.1.1 m.30671 sp RIR2_OSHVF 99.655 579 2 0 1 579 1 579 0 1201 RIR2_OSHVF reviewed Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) ORF20 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 579 deoxyribonucleoside diphosphate metabolic process [GO:0009186]; DNA replication [GO:0006260] GO:0004748; GO:0006260; GO:0009186; GO:0046872 PATHWAY: Genetic information processing; DNA replication. 0 0 PF02661;PF00268; Q6R7K4 CHOYP_Y022.1.1 m.30672 sp Y019_OSHVF 100 357 0 0 1 357 1 357 0 737 Y019_OSHVF reviewed Uncharacterized protein ORF19 ORF19 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 402 0 0 0 0 0 0 Q6R7L3 CHOYP_OSHV1_GP010.1.2 m.28853 sp Y010_OSHVF 99.708 342 1 0 1 342 1 342 0 710 Y010_OSHVF reviewed Uncharacterized protein ORF10 ORF10 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 342 0 0 0 0 0 0 Q6R7L3 CHOYP_OSHV1_GP010.2.2 m.30531 sp Y010_OSHVF 99.708 342 1 0 1 342 1 342 0 710 Y010_OSHVF reviewed Uncharacterized protein ORF10 ORF10 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 342 0 0 0 0 0 0 Q6R7L4 CHOYP_OSHV1_GP010.1.2 m.28852 sp Y009_OSHVF 98.637 587 7 1 1 587 1 586 0 1189 Y009_OSHVF reviewed Putative RING finger protein ORF9 ORF9 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 592 0 GO:0008270 0 0 0 0 Q6R7L4 CHOYP_OSHV1_GP010.2.2 m.30530 sp Y009_OSHVF 98.807 587 6 1 1 587 1 586 0 1192 Y009_OSHVF reviewed Putative RING finger protein ORF9 ORF9 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 592 0 GO:0008270 0 0 0 0 Q6R7L5 CHOYP_OSHV1_GP010.1.2 m.28854 sp Y008_OSHVF 100 319 0 0 1 319 1 319 0 666 Y008_OSHVF reviewed Uncharacterized protein ORF8 ORF8 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 319 0 0 0 0 0 0 Q6R7L6 CHOYP_PRIM.1.1 m.30784 sp PRIM_OSHVF 99.577 1181 4 1 1 1180 1 1181 0 2448 PRIM_OSHVF reviewed Putative primase (EC 2.7.7.-) ORF7 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 1181 0 GO:0003896 0 0 0 PF01896; Q6R7L7 CHOYP_PRIM.1.1 m.30785 sp Y006_OSHVF 100 676 0 0 1 676 1 676 0 1398 Y006_OSHVF reviewed Uncharacterized protein ORF6 ORF6 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 676 0 0 0 0 0 0 Q6RWA9 CHOYP_AT1A.1.1 m.18017 sp AT1A_TAESO 77.679 1017 220 6 112 1126 3 1014 0 1644 AT1A_TAESO reviewed Sodium/potassium-transporting ATPase subunit alpha (Na(+)/K(+) ATPase alpha subunit) (EC 3.6.3.9) (Sodium pump subunit alpha) (TNaK1-alpha) 0 Taenia solium (Pork tapeworm) 1014 0 GO:0005391; GO:0005524; GO:0016021; GO:0046872 0 0 0 PF00689;PF00690;PF00122; Q6TGS6 CHOYP_SYYC.1.2 m.23460 sp SYYC_DANRE 67.089 553 146 3 17 566 5 524 0 739 SYYC_DANRE reviewed "Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)" yars Danio rerio (Zebrafish) (Brachydanio rerio) 529 cellular response to DNA damage stimulus [GO:0006974]; tyrosyl-tRNA aminoacylation [GO:0006437]; valyl-tRNA aminoacylation [GO:0006438] GO:0000049; GO:0004831; GO:0004832; GO:0005524; GO:0005737; GO:0006437; GO:0006438; GO:0006974 0 0 0 PF00579;PF01588; Q6TGS6 CHOYP_SYYC.2.2 m.58390 sp SYYC_DANRE 71.073 522 146 3 17 535 5 524 0 749 SYYC_DANRE reviewed "Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS)" yars Danio rerio (Zebrafish) (Brachydanio rerio) 529 cellular response to DNA damage stimulus [GO:0006974]; tyrosyl-tRNA aminoacylation [GO:0006437]; valyl-tRNA aminoacylation [GO:0006438] GO:0000049; GO:0004831; GO:0004832; GO:0005524; GO:0005737; GO:0006437; GO:0006438; GO:0006974 0 0 0 PF00579;PF01588; Q6TH15 CHOYP_BRAFLDRAFT_228853.1.1 m.9833 sp EIF3D_DANRE 68.914 534 162 4 1 532 1 532 0 792 EIF3D_DANRE reviewed Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) eif3d eif3s7 si:dkey-165I8.6 Danio rerio (Zebrafish) (Brachydanio rerio) 552 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0003743; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF05091; Q6TH15 CHOYP_SC31A.2.2 m.18645 sp EIF3D_DANRE 68.914 534 162 4 1 532 1 532 0 783 EIF3D_DANRE reviewed Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) eif3d eif3s7 si:dkey-165I8.6 Danio rerio (Zebrafish) (Brachydanio rerio) 552 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0003743; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF05091; Q6UR05 CHOYP_LOC100742783.1.1 m.55861 sp MRP1_CANLF 52.018 1140 522 6 1 1129 406 1531 0 1171 MRP1_CANLF reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Canis lupus familiaris (Dog) (Canis familiaris) 1531 0 GO:0005524; GO:0005886; GO:0016021; GO:0042626 0 0 0 PF00664;PF00005; Q6UVM3 CHOYP_KCNT2.1.1 m.43839 sp KCNT2_HUMAN 39.187 1156 596 23 34 1148 35 1124 0 804 KCNT2_HUMAN reviewed Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Homo sapiens (Human) 1135 0 GO:0005249; GO:0005524; GO:0008076; GO:0015269 0 0 0 PF03493;PF07885; Q6UVM3 CHOYP_LOC655919.1.1 m.52118 sp KCNT2_HUMAN 52.092 1171 466 12 56 1200 32 1133 0 1229 KCNT2_HUMAN reviewed Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Homo sapiens (Human) 1135 0 GO:0005249; GO:0005524; GO:0008076; GO:0015269 0 0 0 PF03493;PF07885; Q6UW63 CHOYP_KDEL1.1.1 m.62729 sp KDEL1_HUMAN 56.851 489 205 4 27 514 19 502 0 556 KDEL1_HUMAN reviewed KDEL motif-containing protein 1 (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58) KDELC1 EP58 UNQ1910/PRO4357 Homo sapiens (Human) 502 glycolipid metabolic process [GO:0006664] GO:0005788; GO:0006664; GO:0046527 0 0 0 PF00630;PF05686; Q6UWX4 CHOYP_LOC100313632.1.1 m.41379 sp HIPL2_HUMAN 45.185 675 331 10 18 662 36 701 0 578 HIPL2_HUMAN reviewed HHIP-like protein 2 HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779 Homo sapiens (Human) 724 carbohydrate metabolic process [GO:0005975] GO:0005576; GO:0005975; GO:0016901; GO:0048038 0 0 0 PF03024;PF07995; Q6V0I7 CHOYP_LOC659713.1.1 m.21648 sp FAT4_HUMAN 35.024 5105 2967 112 25 4934 27 4976 0 2650 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q6VNB8 CHOYP_BRAFLDRAFT_202950.1.1 m.51601 sp WDFY3_MOUSE 50.861 3659 1524 59 1 3537 1 3507 0 3602 WDFY3_MOUSE reviewed "WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1)" Wdfy3 Mus musculus (Mouse) 3508 aggrephagy [GO:0035973]; positive regulation of macroautophagy [GO:0016239] GO:0003831; GO:0005543; GO:0005545; GO:0005635; GO:0005737; GO:0005776; GO:0012505; GO:0016234; GO:0016239; GO:0016605; GO:0019898; GO:0031965; GO:0034274; GO:0035973; GO:0046872; GO:0097635 0 0 cd06071; PF02138;PF15787;PF01363;PF14844;PF00400; Q6VVX2 CHOYP_C43BP.1.1 m.62099 sp C43BP_CRIGR 54.844 578 242 9 33 600 30 598 0 640 C43BP_CRIGR reviewed Collagen type IV alpha-3-binding protein (Ceramide transfer protein) COL4A3BP CERT Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 598 ER to Golgi ceramide transport [GO:0035621] GO:0005783; GO:0005794; GO:0005829; GO:0035621; GO:0070273 0 0 0 PF00169;PF01852; Q6WKZ8 CHOYP_UBR2.2.2 m.54412 sp UBR2_MOUSE 44.533 1756 876 39 47 1757 53 1755 0 1413 UBR2_MOUSE reviewed E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) Ubr2 Kiaa0349 Mus musculus (Mouse) 1755 cellular response to leucine [GO:0071233]; chromatin silencing [GO:0006342]; histone H2A ubiquitination [GO:0033522]; male meiosis I [GO:0007141]; negative regulation of TOR signaling [GO:0032007]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] GO:0000151; GO:0004842; GO:0005654; GO:0005737; GO:0005886; GO:0006342; GO:0006511; GO:0007141; GO:0007283; GO:0008270; GO:0016874; GO:0032007; GO:0033522; GO:0061630; GO:0070728; GO:0071233; GO:0071596 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02617;PF02207; Q6XUX3 CHOYP_NEMVEDRAFT_V1G241055.1.1 m.64781 sp DUSTY_HUMAN 48.031 914 394 12 34 941 80 918 0 829 DUSTY_HUMAN reviewed Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496) DSTYK KIAA0472 RIP5 RIPK5 SGK496 HDCMD38P Homo sapiens (Human) 929 cellular response to fibroblast growth factor stimulus [GO:0044344]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005829; GO:0016323; GO:0016324; GO:0030054; GO:0033674; GO:0044344; GO:0045743; GO:0070374 0 0 0 PF07714; Q6YHK3 CHOYP_CD109.1.2 m.7033 sp CD109_HUMAN 33.377 1513 856 36 11 1482 12 1413 0 761 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q6YHK3 CHOYP_TRIADDRAFT_55768.2.2 m.14361 sp CD109_HUMAN 35.15 1468 827 29 19 1443 28 1413 0 851 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q6ZMV9 CHOYP_KIF6.1.1 m.52867 sp KIF6_HUMAN 53.855 843 345 9 1 831 1 811 0 867 KIF6_HUMAN reviewed Kinesin-like protein KIF6 KIF6 C6orf102 Homo sapiens (Human) 814 microtubule-based movement [GO:0007018] GO:0001673; GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF00225; Q6ZMW3 CHOYP_EMAL6.1.1 m.6370 sp EMAL6_HUMAN 65.211 1969 665 8 1 1960 1 1958 0 2729 EMAL6_HUMAN reviewed Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) EML6 EML5L Homo sapiens (Human) 1958 0 GO:0005737; GO:0005874 0 0 0 PF12894;PF03451;PF00400; Q6ZN16 CHOYP_ASK1.1.2 m.586 sp M3K15_HUMAN 44.152 1291 612 19 39 1294 86 1302 0 1062 M3K15_HUMAN reviewed Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) MAP3K15 ASK3 Homo sapiens (Human) 1313 activation of MAPKK activity [GO:0000186] GO:0000186; GO:0004709; GO:0005524; GO:0005622; GO:0046872 0 0 0 PF13281;PF00069; Q6ZN16 CHOYP_ASK1.2.2 m.4199 sp M3K15_HUMAN 43.598 1312 610 21 39 1315 86 1302 0 1053 M3K15_HUMAN reviewed Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15) MAP3K15 ASK3 Homo sapiens (Human) 1313 activation of MAPKK activity [GO:0000186] GO:0000186; GO:0004709; GO:0005524; GO:0005622; GO:0046872 0 0 0 PF13281;PF00069; Q6ZPF4 CHOYP_ISCW_ISCW017809.2.2 m.53163 sp FMNL3_MOUSE 48.748 1038 445 18 78 1051 1 1015 0 880 FMNL3_MOUSE reviewed Formin-like protein 3 Fmnl3 Frl2 Kiaa2014 Mus musculus (Mouse) 1028 actin cytoskeleton organization [GO:0030036]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360] GO:0001525; GO:0005737; GO:0005886; GO:0007010; GO:0008360; GO:0016477; GO:0030036; GO:0032794 0 0 0 PF06367;PF06371;PF02181; Q6ZPY2 CHOYP_SMG5.1.1 m.21320 sp SMG5_MOUSE 36.372 1075 567 25 236 1290 7 984 0 577 SMG5_MOUSE reviewed Protein SMG5 (EST1-like protein B) (SMG-5 homolog) Smg5 Est1b Kiaa1089 Mus musculus (Mouse) 1017 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of dephosphorylation [GO:0035303]; regulation of telomere maintenance [GO:0032204]" GO:0000184; GO:0005634; GO:0005737; GO:0031625; GO:0032204; GO:0035303; GO:0042162; GO:0042826; GO:0051721; GO:0070182 0 0 0 PF10374;PF10373;PF13638; Q6ZQ08 CHOYP_CNOT1.1.1 m.12104 sp CNOT1_MOUSE 61.78 2449 838 32 1 2429 1 2371 0 2973 CNOT1_MOUSE reviewed CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) Cnot1 Kiaa1007 Mus musculus (Mouse) 2375 "gene silencing by miRNA [GO:0035195]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of stem cell population maintenance [GO:2000036]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; transcription, DNA-templated [GO:0006351]; trophectodermal cell differentiation [GO:0001829]" GO:0000122; GO:0000288; GO:0000932; GO:0001829; GO:0005615; GO:0005634; GO:0005737; GO:0006351; GO:0010606; GO:0016020; GO:0017148; GO:0019904; GO:0030014; GO:0030015; GO:0030331; GO:0032947; GO:0033147; GO:0035195; GO:0042974; GO:0043231; GO:0044822; GO:0048387; GO:0060213; GO:0061014; GO:0070016; GO:0090503; GO:1900153; GO:2000036 0 0 0 PF16415;PF16418;PF16417;PF12842;PF04054; Q6ZQ11 CHOYP_CHSY3.1.1 m.8265 sp CHSS1_MOUSE 44.832 716 352 10 87 775 80 779 0 660 CHSS1_MOUSE reviewed Chondroitin sulfate synthase 1 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 1) (Chondroitin synthase 1) (ChSy-1) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1) (N-acetylgalactosaminyltransferase 1) Chsy1 Kiaa0990 Mus musculus (Mouse) 800 bone morphogenesis [GO:0060349]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; negative regulation of ossification [GO:0030279]; positive regulation of smoothened signaling pathway [GO:0045880]; proximal/distal pattern formation [GO:0009954]; response to nutrient levels [GO:0031667]; sulfation [GO:0051923] GO:0002063; GO:0005576; GO:0009954; GO:0016020; GO:0016021; GO:0016757; GO:0030206; GO:0030279; GO:0031667; GO:0032580; GO:0045880; GO:0046872; GO:0047238; GO:0050510; GO:0051216; GO:0051923; GO:0060349 0 0 0 PF05679; Q6ZQ58 CHOYP_LOC100552337.1.1 m.19614 sp LARP1_MOUSE 50.271 738 299 21 351 1047 362 1072 0 674 LARP1_MOUSE reviewed La-related protein 1 (La ribonucleoprotein domain family member 1) Larp1 Kiaa0731 Larp Mus musculus (Mouse) 1072 cell proliferation [GO:0008283]; positive regulation of macroautophagy [GO:0016239]; positive regulation of viral genome replication [GO:0045070]; TOR signaling [GO:0031929]; translational initiation [GO:0006413] GO:0000339; GO:0003730; GO:0005654; GO:0005737; GO:0006413; GO:0008190; GO:0008283; GO:0008494; GO:0016020; GO:0016239; GO:0031369; GO:0031929; GO:0031931; GO:0044822; GO:0045070; GO:0048027 0 0 0 PF05383; Q6ZQ89 CHOYP_MARH6.1.1 m.11430 sp MARH6_MOUSE 69.053 908 260 6 20 917 1 897 0 1196 MARH6_MOUSE reviewed E3 ubiquitin-protein ligase MARCH6 (EC 6.3.2.-) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) March6 Kiaa0597 Mus musculus (Mouse) 909 proteasomal protein catabolic process [GO:0010498]; protein K48-linked ubiquitination [GO:0070936] GO:0004842; GO:0008270; GO:0010498; GO:0016020; GO:0016021; GO:0016874; GO:0019899; GO:0030176; GO:0031624; GO:0070936; GO:1990381 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q6ZS30 CHOYP_LOC580791.1.1 m.51394 sp NBEL1_HUMAN 46.083 1621 838 18 1 1609 1067 2663 0 1443 NBEL1_HUMAN reviewed Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) 2694 0 GO:0005543; GO:0012505; GO:0019898 0 0 cd06071; PF02138;PF15787;PF14844;PF00400; Q6ZS30 CHOYP_NBEL1.1.1 m.33217 sp NBEL1_HUMAN 42.42 2711 1427 37 1 2658 34 2663 0 2114 NBEL1_HUMAN reviewed Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) 2694 0 GO:0005543; GO:0012505; GO:0019898 0 0 cd06071; PF02138;PF15787;PF14844;PF00400; Q6ZT07 CHOYP_BRAFLDRAFT_153908.1.2 m.1377 sp TBCD9_HUMAN 44.678 1334 550 20 1 1229 1 1251 0 1100 TBCD9_HUMAN reviewed TBC1 domain family member 9 (TBC1 domain family member 9A) TBC1D9 KIAA0882 TBC1D9A Homo sapiens (Human) 1266 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005509; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF02893;PF00566; Q6ZT07 CHOYP_BRAFLDRAFT_153908.2.2 m.23497 sp TBCD9_HUMAN 43.035 1364 559 21 1 1259 1 1251 0 1081 TBCD9_HUMAN reviewed TBC1 domain family member 9 (TBC1 domain family member 9A) TBC1D9 KIAA0882 TBC1D9A Homo sapiens (Human) 1266 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005509; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF02893;PF00566; Q6ZTR5 CHOYP_BRAFLDRAFT_121927.1.1 m.47211 sp CFA47_HUMAN 34.853 1974 1181 31 1278 3207 1187 3099 0 1130 CFA47_HUMAN reviewed Cilia- and flagella-associated protein 47 CFAP47 CHDC2 CXorf22 CXorf30 CXorf59 Homo sapiens (Human) 3102 0 0 0 0 0 0 Q6ZV73 CHOYP_FGD6.1.1 m.42769 sp FGD6_HUMAN 46.984 630 297 7 910 1518 817 1430 0 599 FGD6_HUMAN reviewed "FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)" FGD6 KIAA1362 ZFYVE24 Homo sapiens (Human) 1430 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023] GO:0001726; GO:0005085; GO:0005089; GO:0005737; GO:0005794; GO:0005856; GO:0007010; GO:0008360; GO:0030027; GO:0030036; GO:0031267; GO:0035023; GO:0043087; GO:0046847; GO:0046872 0 0 0 PF01363;PF00169;PF00621; Q6ZWH5 CHOYP_BRAFLDRAFT_76429.1.1 m.33502 sp NEK10_HUMAN 47.454 864 415 12 1 850 1 839 0 773 NEK10_HUMAN reviewed Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10) NEK10 Homo sapiens (Human) 1172 chromosome segregation [GO:0007059]; microtubule-based process [GO:0007017]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein autophosphorylation [GO:0031954]; protein phosphorylation [GO:0006468]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of ERK1 and ERK2 cascade [GO:0070372] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0007017; GO:0007059; GO:0031954; GO:0043406; GO:0046872; GO:0070372; GO:1902749; GO:1902911 0 0 0 PF00069; Q6ZZY0 CHOYP_CRY1.2.2 m.48172 sp CRY1_SYLBO 75.449 501 120 1 9 506 4 504 0 825 CRY1_SYLBO reviewed Cryptochrome-1 CRY1 Sylvia borin (Garden warbler) 620 "protein-chromophore linkage [GO:0018298]; regulation of transcription, DNA-templated [GO:0006355]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0009881; GO:0018298; GO:0042622; GO:0048511; GO:0097381 0 0 0 PF00875;PF03441; Q704S8 CHOYP_BRAFLDRAFT_83552.1.1 m.55255 sp CACP_RAT 50.413 605 291 7 52 651 26 626 0 658 CACP_RAT reviewed Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT) Crat Rattus norvegicus (Rat) 626 fatty acid metabolic process [GO:0006631]; transport [GO:0006810] GO:0004092; GO:0005739; GO:0005743; GO:0005777; GO:0005783; GO:0006631; GO:0006810 0 0 0 PF00755; Q70CQ2 CHOYP_UBP34.1.1 m.55124 sp UBP34_HUMAN 52.598 2829 1190 49 320 3070 659 3414 0 2858 UBP34_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) 3546 "histone deubiquitination [GO:0016578]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; regulation of transcription, DNA-templated [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]" GO:0000124; GO:0004197; GO:0004843; GO:0005829; GO:0006355; GO:0006511; GO:0016055; GO:0016578; GO:0016579; GO:0071108; GO:0090263 0 0 0 PF00443; Q70JS2 CHOYP_BRAFLDRAFT_203117.1.1 m.61687 sp KELC_ANOST 68.149 562 178 1 21 582 76 636 0 825 KELC_ANOST reviewed Ring canal kelch homolog (Kelch-like protein 1) [Cleaved into: Kelch short protein] kel Anopheles stephensi (Indo-Pakistan malaria mosquito) 1499 0 GO:0005737; GO:0005856 0 0 0 PF07707;PF00651;PF01344; Q711T7 CHOYP_NEMVEDRAFT_V1G173435.1.1 m.37344 sp NADE_MOUSE 64.566 714 252 1 1 713 1 714 0 995 NADE_MOUSE reviewed Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) (NH3-dependent NAD(+) synthetase-like protein) Nadsyn1 Mus musculus (Mouse) 725 NAD biosynthetic process [GO:0009435] GO:0003952; GO:0004359; GO:0005524; GO:0005737; GO:0008795; GO:0009435 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. 0 cd00553; PF00795;PF02540; Q71B07 CHOYP_DPY19L3.1.1 m.7532 sp D19L3_MOUSE 48.811 631 314 6 109 735 67 692 0 613 D19L3_MOUSE reviewed Probable C-mannosyltransferase DPY19L3 (EC 2.4.1.-) (Dpy-19-like protein 3) (Protein dpy-19 homolog 3) Dpy19l3 Mus musculus (Mouse) 716 protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan [GO:0018406] GO:0000030; GO:0005637; GO:0016021; GO:0018406 0 0 0 PF10034; Q75NR7 CHOYP_LOC567383.1.1 m.16245 sp RECQ4_MOUSE 41.026 1053 497 27 342 1362 252 1212 0 738 RECQ4_MOUSE reviewed "ATP-dependent DNA helicase Q4 (EC 3.6.4.12) (DNA helicase, RecQ-like type 4) (RecQ4) (RecQ protein-like 4)" Recql4 Recq4 Mus musculus (Mouse) 1216 base-excision repair [GO:0006284]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA replication [GO:0006260]; DNA strand renaturation [GO:0000733]; double-strand break repair [GO:0006302]; negative regulation of sister chromatid cohesion [GO:0045875]; pigmentation [GO:0043473]; positive regulation of cell proliferation [GO:0008284]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705] GO:0000405; GO:0000733; GO:0001501; GO:0003677; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006260; GO:0006284; GO:0006302; GO:0006310; GO:0008270; GO:0008284; GO:0009378; GO:0016020; GO:0032508; GO:0036310; GO:0043140; GO:0043473; GO:0045875; GO:0048705 0 0 0 PF00270;PF11719;PF00271;PF00098; Q75WS4 CHOYP_CRYD.1.1 m.65088 sp CRYD_XENLA 62.042 519 182 7 1 506 1 517 0 682 CRYD_XENLA reviewed Cryptochrome DASH cry-dash Xenopus laevis (African clawed frog) 523 DNA repair [GO:0006281]; protein-chromophore linkage [GO:0018298] GO:0003913; GO:0006281; GO:0018298 0 0 0 PF00875;PF03441; Q761V0 CHOYP_DGRI_GH22876.2.3 m.54068 sp SC6A5_MOUSE 44.554 606 322 6 88 687 165 762 0 542 SC6A5_MOUSE reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) 799 "glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]" GO:0005328; GO:0005886; GO:0005887; GO:0015375; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q761V0 CHOYP_SC6A9.5.6 m.26569 sp SC6A5_MOUSE 44.304 632 311 11 4 619 189 795 0 545 SC6A5_MOUSE reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) 799 "glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]" GO:0005328; GO:0005886; GO:0005887; GO:0015375; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q761V0 CHOYP_SMP_028690.1.1 m.57095 sp SC6A5_MOUSE 45.923 601 295 6 71 655 184 770 0 549 SC6A5_MOUSE reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) 799 "glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]" GO:0005328; GO:0005886; GO:0005887; GO:0015375; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q761X5 CHOYP_BRAFLDRAFT_209377.1.1 m.60234 sp UNC5C_RAT 36.88 968 502 26 26 967 44 928 0 612 UNC5C_RAT reviewed Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) Unc5c Unc5h3 Rattus norvegicus (Rat) 931 apoptotic process [GO:0006915]; multicellular organism development [GO:0007275]; signal transduction [GO:0007165] GO:0005886; GO:0006915; GO:0007165; GO:0007275; GO:0016021; GO:0030054; GO:0043005; GO:0045202 0 0 0 PF00531;PF07679;PF00090;PF00791; Q761X5 CHOYP_LOC100569275.1.1 m.62629 sp UNC5C_RAT 36.556 993 495 28 26 991 44 928 0 605 UNC5C_RAT reviewed Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) Unc5c Unc5h3 Rattus norvegicus (Rat) 931 apoptotic process [GO:0006915]; multicellular organism development [GO:0007275]; signal transduction [GO:0007165] GO:0005886; GO:0006915; GO:0007165; GO:0007275; GO:0016021; GO:0030054; GO:0043005; GO:0045202 0 0 0 PF00531;PF07679;PF00090;PF00791; Q767L0 CHOYP_LOC100863242.1.1 m.9849 sp ABCF1_PIG 65.657 594 197 4 155 745 218 807 0 728 ABCF1_PIG reviewed ATP-binding cassette sub-family F member 1 ABCF1 Sus scrofa (Pig) 807 positive regulation of translation [GO:0045727]; translational initiation [GO:0006413] GO:0005524; GO:0005635; GO:0005654; GO:0005737; GO:0006413; GO:0008494; GO:0016887; GO:0042788; GO:0043022; GO:0045727 0 0 0 PF00005;PF12848; Q78PY7 CHOYP_LOC594315.1.1 m.28047 sp SND1_MOUSE 58.324 907 353 13 8 904 19 910 0 1056 SND1_MOUSE reviewed Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (p100 co-activator) Snd1 Mus musculus (Mouse) 910 "gene silencing by RNA [GO:0031047]; osteoblast differentiation [GO:0001649]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001649; GO:0004518; GO:0005634; GO:0005737; GO:0005739; GO:0006351; GO:0006355; GO:0016020; GO:0016442; GO:0031047; GO:0042470; GO:0044822; GO:0070062; GO:0097433 0 0 0 PF00565;PF00567; Q7JQ32 CHOYP_DERE_GG13375.1.1 m.33536 sp GC76C_DROME 45.855 1158 544 26 13 1124 8 1128 0 924 GC76C_DROME reviewed Receptor-type guanylate cyclase Gyc76C (EC 4.6.1.2) (DrGC-1) Gyc76C CG42636 Drosophila melanogaster (Fruit fly) 1525 "axon midline choice point recognition [GO:0016199]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; extracellular matrix organization [GO:0030198]; larval somatic muscle development [GO:0007526]; motor neuron axon guidance [GO:0008045]; primary branching, open tracheal system [GO:0007428]; protein phosphorylation [GO:0006468]; regulation of BMP signaling pathway [GO:0030510]; response to salt stress [GO:0009651]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]" GO:0001653; GO:0004383; GO:0004872; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0006468; GO:0007165; GO:0007428; GO:0007435; GO:0007526; GO:0008045; GO:0008074; GO:0009651; GO:0016199; GO:0019934; GO:0030198; GO:0030510; GO:0046872 0 0 0 PF01094;PF00211;PF07714; Q7JQ32 CHOYP_LOC100748515.1.1 m.26148 sp GC76C_DROME 43.093 1151 547 28 7 1092 8 1115 0 853 GC76C_DROME reviewed Receptor-type guanylate cyclase Gyc76C (EC 4.6.1.2) (DrGC-1) Gyc76C CG42636 Drosophila melanogaster (Fruit fly) 1525 "axon midline choice point recognition [GO:0016199]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; extracellular matrix organization [GO:0030198]; larval somatic muscle development [GO:0007526]; motor neuron axon guidance [GO:0008045]; primary branching, open tracheal system [GO:0007428]; protein phosphorylation [GO:0006468]; regulation of BMP signaling pathway [GO:0030510]; response to salt stress [GO:0009651]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]" GO:0001653; GO:0004383; GO:0004872; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0006468; GO:0007165; GO:0007428; GO:0007435; GO:0007526; GO:0008045; GO:0008074; GO:0009651; GO:0016199; GO:0019934; GO:0030198; GO:0030510; GO:0046872 0 0 0 PF01094;PF00211;PF07714; Q7JQ32 CHOYP_LOC100872200.1.1 m.26457 sp GC76C_DROME 51.799 695 299 14 9 683 437 1115 0 672 GC76C_DROME reviewed Receptor-type guanylate cyclase Gyc76C (EC 4.6.1.2) (DrGC-1) Gyc76C CG42636 Drosophila melanogaster (Fruit fly) 1525 "axon midline choice point recognition [GO:0016199]; cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; extracellular matrix organization [GO:0030198]; larval somatic muscle development [GO:0007526]; motor neuron axon guidance [GO:0008045]; primary branching, open tracheal system [GO:0007428]; protein phosphorylation [GO:0006468]; regulation of BMP signaling pathway [GO:0030510]; response to salt stress [GO:0009651]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]" GO:0001653; GO:0004383; GO:0004872; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0006468; GO:0007165; GO:0007428; GO:0007435; GO:0007526; GO:0008045; GO:0008074; GO:0009651; GO:0016199; GO:0019934; GO:0030198; GO:0030510; GO:0046872 0 0 0 PF01094;PF00211;PF07714; Q7JZB4 CHOYP_NEMVEDRAFT_V1G162365.1.1 m.8038 sp GMPPB_DROME 76.323 359 84 1 2 360 12 369 0 574 GMPPB_DROME reviewed Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) CG1129 Drosophila melanogaster (Fruit fly) 369 GDP-mannose biosynthetic process [GO:0009298]; larval lymph gland hemopoiesis [GO:0035167] GO:0004475; GO:0005525; GO:0009298; GO:0035167 PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. 0 0 PF00132;PF00483; Q7K4Y6 CHOYP_AAEL_AAEL010106.1.1 m.59779 sp DAT_DROME 59.68 625 235 4 27 637 8 629 0 744 DAT_DROME reviewed Sodium-dependent dopamine transporter (Protein fumin) DAT fmn CG8380 Drosophila melanogaster (Fruit fly) 631 circadian sleep/wake cycle [GO:0042745]; dopamine transport [GO:0015872]; dopamine uptake involved in synaptic transmission [GO:0051583]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; response to odorant [GO:1990834]; sleep [GO:0030431] GO:0005329; GO:0005330; GO:0005887; GO:0015872; GO:0019811; GO:0030431; GO:0042745; GO:0043005; GO:0046872; GO:0051583; GO:0098793; GO:0099509; GO:1990834 0 0 0 PF00209; Q7KVW5 CHOYP_DGRI_GH24618.1.2 m.1995 sp KCNN_DROME 53.707 553 193 8 174 690 373 898 0 602 KCNN_DROME reviewed Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) 927 potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057] GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016021; GO:0016057; GO:0016286; GO:0043025 0 0 0 PF02888;PF07885;PF03530; Q7KVW5 CHOYP_DGRI_GH24618.2.2 m.54350 sp KCNN_DROME 55.009 529 199 7 174 666 373 898 0 602 KCNN_DROME reviewed Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) 927 potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057] GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016021; GO:0016057; GO:0016286; GO:0043025 0 0 0 PF02888;PF07885;PF03530; Q7KZ85 CHOYP_SPT6H.1.1 m.55595 sp SPT6H_HUMAN 56.102 1647 651 23 115 1716 104 1723 0 1795 SPT6H_HUMAN reviewed Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) SUPT6H KIAA0162 SPT6H Homo sapiens (Human) 1726 "chromatin remodeling [GO:0006338]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of histone H3-K27 methylation [GO:0061086]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; regulation of isotype switching [GO:0045191]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of muscle cell differentiation [GO:0051147]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0003677; GO:0003700; GO:0005634; GO:0006338; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0010793; GO:0016032; GO:0032968; GO:0042393; GO:0044822; GO:0045191; GO:0050684; GO:0051028; GO:0051147; GO:0061086 0 0 0 PF14878;PF14635;PF14641;PF00575;PF14633;PF14632;PF14639; Q7L5Y6 CHOYP_DET1.1.2 m.11311 sp DET1_HUMAN 72.222 540 145 2 23 558 10 548 0 808 DET1_HUMAN reviewed DET1 homolog (De-etiolated-1 homolog) DET1 Homo sapiens (Human) 550 0 GO:0005634 0 0 0 PF09737; Q7L7X3 CHOYP_ISCW_ISCW014880.1.1 m.27977 sp TAOK1_HUMAN 55.446 909 350 7 1 864 1 899 0 951 TAOK1_HUMAN reviewed Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1) TAOK1 KIAA1361 MAP3K16 MARKK Homo sapiens (Human) 1001 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; execution phase of apoptosis [GO:0097194]; G2 DNA damage checkpoint [GO:0031572]; positive regulation of JNK cascade [GO:0046330]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein phosphorylation [GO:0006468]; regulation of cytoskeleton organization [GO:0051493]; sister chromatid cohesion [GO:0007062] GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005829; GO:0006281; GO:0006468; GO:0006974; GO:0007062; GO:0016301; GO:0016740; GO:0031572; GO:0032874; GO:0046330; GO:0051493; GO:0070062; GO:0097194 0 0 0 PF00069; Q7LBC6 CHOYP_LOC100378099.1.1 m.22676 sp KDM3B_HUMAN 46.145 908 383 22 1697 2538 888 1755 0 760 KDM3B_HUMAN reviewed Lysine-specific demethylase 3B (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) KDM3B C5orf7 JHDM2B JMJD1B KIAA1082 Homo sapiens (Human) 1761 "regulation of transcription, DNA-templated [GO:0006355]; response to cisplatin [GO:0072718]; transcription, DNA-templated [GO:0006351]" GO:0005654; GO:0006351; GO:0006355; GO:0016209; GO:0032452; GO:0046872; GO:0051213; GO:0072718 0 0 0 PF02373; Q7M6Y3 CHOYP_LOC654860.1.3 m.1775 sp PICAL_MOUSE 47.016 687 240 22 62 661 1 650 0 541 PICAL_MOUSE reviewed Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia) (CALM) Picalm Calm Fit1 Mus musculus (Mouse) 660 "axonogenesis [GO:0007409]; cargo loading into vesicle [GO:0035459]; cell proliferation [GO:0008283]; clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; iron ion homeostasis [GO:0055072]; iron ion import into cell [GO:0097459]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of beta-amyloid formation [GO:1902004]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription, DNA-templated [GO:0045893]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; synaptic vesicle maturation [GO:0016188]" GO:0005545; GO:0005622; GO:0005634; GO:0005794; GO:0005905; GO:0006898; GO:0007409; GO:0008283; GO:0010629; GO:0016020; GO:0016188; GO:0016197; GO:0030097; GO:0030100; GO:0030136; GO:0030276; GO:0031623; GO:0031982; GO:0032050; GO:0032880; GO:0035459; GO:0035615; GO:0043025; GO:0045893; GO:0048261; GO:0048268; GO:0048813; GO:0055072; GO:0072583; GO:0097418; GO:0097459; GO:1901216; GO:1902004; GO:1902959; GO:1902961; GO:1902963 0 0 0 PF07651; Q7M6Y3 CHOYP_LOC654860.2.3 m.4633 sp PICAL_MOUSE 46.505 701 255 25 1 632 1 650 0 538 PICAL_MOUSE reviewed Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia) (CALM) Picalm Calm Fit1 Mus musculus (Mouse) 660 "axonogenesis [GO:0007409]; cargo loading into vesicle [GO:0035459]; cell proliferation [GO:0008283]; clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; iron ion homeostasis [GO:0055072]; iron ion import into cell [GO:0097459]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of beta-amyloid formation [GO:1902004]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription, DNA-templated [GO:0045893]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; synaptic vesicle maturation [GO:0016188]" GO:0005545; GO:0005622; GO:0005634; GO:0005794; GO:0005905; GO:0006898; GO:0007409; GO:0008283; GO:0010629; GO:0016020; GO:0016188; GO:0016197; GO:0030097; GO:0030100; GO:0030136; GO:0030276; GO:0031623; GO:0031982; GO:0032050; GO:0032880; GO:0035459; GO:0035615; GO:0043025; GO:0045893; GO:0048261; GO:0048268; GO:0048813; GO:0055072; GO:0072583; GO:0097418; GO:0097459; GO:1901216; GO:1902004; GO:1902959; GO:1902961; GO:1902963 0 0 0 PF07651; Q7M760 CHOYP_ZRN1B.1.1 m.18903 sp ZRAN1_MOUSE 50.693 722 290 19 7 700 7 690 0 664 ZRAN1_MOUSE reviewed Ubiquitin thioesterase Zranb1 (EC 3.4.19.12) (Zinc finger Ran-binding domain-containing protein 1) Zranb1 Trabid Mus musculus (Mouse) 708 cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; positive regulation of Wnt signaling pathway [GO:0030177]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K63-linked deubiquitination [GO:0070536]; regulation of cell morphogenesis [GO:0022604]; Wnt signaling pathway [GO:0016055] GO:0004843; GO:0005634; GO:0005654; GO:0005737; GO:0007010; GO:0008270; GO:0016055; GO:0016477; GO:0022604; GO:0030177; GO:0035523; GO:0070530; GO:0070536; GO:0071947; GO:1990168 0 0 0 PF02338;PF00641; Q7PHR1 CHOYP_LOC100875479.1.2 m.42509 sp KIF1A_ANOGA 59.848 1711 585 28 1 1676 1 1644 0 1952 KIF1A_ANOGA reviewed Kinesin-like protein unc-104 unc-104 AGAP010519 Anopheles gambiae (African malaria mosquito) 1644 cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0005875; GO:0007018; GO:0016887; GO:0030705; GO:0047496; GO:0048489 0 0 0 PF12473;PF00498;PF12423;PF00225;PF16183;PF00169; Q7PPA5 CHOYP_ATC1.1.1 m.5160 sp ATC1_ANOGA 74.533 1017 256 3 1 1016 1 1015 0 1558 ATC1_ANOGA reviewed Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (EC 3.6.3.8) (Calcium pump) Ca-P60A AGAP006186 Anopheles gambiae (African malaria mosquito) 1018 cellular calcium ion homeostasis [GO:0006874] GO:0005388; GO:0005524; GO:0005887; GO:0006874; GO:0033017; GO:0046872 0 0 0 PF00689;PF00690;PF00122;PF08282; Q7Q1K8 CHOYP_EFGM.1.1 m.16631 sp EFGM_ANOGA 65.483 704 239 2 33 735 24 724 0 975 EFGM_ANOGA reviewed "Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1)" AGAP009737 Anopheles gambiae (African malaria mosquito) 744 mitochondrial translational elongation [GO:0070125] GO:0003746; GO:0003924; GO:0005525; GO:0005739; GO:0070125 PATHWAY: Protein biosynthesis; polypeptide chain elongation. {ECO:0000255|HAMAP-Rule:MF_03061}. 0 cd01434; PF00679;PF14492;PF03764;PF03144; Q7Q1K8 CHOYP_EFGM.1.1 m.16632 sp EFGM_ANOGA 64.266 722 254 2 33 753 24 742 0 978 EFGM_ANOGA reviewed "Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1)" AGAP009737 Anopheles gambiae (African malaria mosquito) 744 mitochondrial translational elongation [GO:0070125] GO:0003746; GO:0003924; GO:0005525; GO:0005739; GO:0070125 PATHWAY: Protein biosynthesis; polypeptide chain elongation. {ECO:0000255|HAMAP-Rule:MF_03061}. 0 cd01434; PF00679;PF14492;PF03764;PF03144; Q7QC84 CHOYP_EF2.5.5 m.39856 sp MMSA_ANOGA 73.938 518 132 1 11 525 4 521 0 808 MMSA_ANOGA reviewed "Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27)" AGAP002499 Anopheles gambiae (African malaria mosquito) 521 0 GO:0004029; GO:0004491; GO:0005739; GO:0018478 0 0 cd07085; PF00171; Q7QC84 CHOYP_MMSA.2.2 m.16271 sp MMSA_ANOGA 73.938 518 132 1 11 525 4 521 0 808 MMSA_ANOGA reviewed "Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27)" AGAP002499 Anopheles gambiae (African malaria mosquito) 521 0 GO:0004029; GO:0004491; GO:0005739; GO:0018478 0 0 cd07085; PF00171; Q7SXM7 CHOYP_PRP31.3.6 m.8812 sp PRP31_DANRE 65.408 503 159 5 1 489 1 502 0 632 PRP31_DANRE reviewed U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Danio rerio (Zebrafish) (Brachydanio rerio) 508 "mRNA splicing, via spliceosome [GO:0000398]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000398; GO:0003723; GO:0005687; GO:0005690; GO:0046540; GO:0060041; GO:0071011; GO:0071339; GO:0097526 0 0 0 PF01798;PF09785; Q7SXM7 CHOYP_PRP31.6.6 m.51908 sp PRP31_DANRE 65.408 503 159 5 1 489 1 502 0 632 PRP31_DANRE reviewed U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Danio rerio (Zebrafish) (Brachydanio rerio) 508 "mRNA splicing, via spliceosome [GO:0000398]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000398; GO:0003723; GO:0005687; GO:0005690; GO:0046540; GO:0060041; GO:0071011; GO:0071339; GO:0097526 0 0 0 PF01798;PF09785; Q7SXN4 CHOYP_LOC100378487.1.1 m.64108 sp CPEB4_DANRE 77.907 344 65 4 334 671 296 634 0 560 CPEB4_DANRE reviewed Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (CPEB-4) cpeb4 zgc:66166 Danio rerio (Zebrafish) (Brachydanio rerio) 635 cellular response to amino acid stimulus [GO:0071230]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; ionotropic glutamate receptor signaling pathway [GO:0035235]; negative regulation of cytoplasmic translation [GO:2000766]; negative regulation of neuron apoptotic process [GO:0043524]; response to ischemia [GO:0002931] GO:0000166; GO:0000900; GO:0002931; GO:0003730; GO:0005634; GO:0005737; GO:0005783; GO:0008135; GO:0014069; GO:0030425; GO:0035235; GO:0036294; GO:0042149; GO:0043005; GO:0043022; GO:0043524; GO:0045202; GO:0071230; GO:1990124; GO:2000766 0 0 0 PF16366;PF16367; Q7SXN5 CHOYP_LOC100646574.1.1 m.55144 sp DNM1L_DANRE 70.707 693 196 5 1 688 1 691 0 986 DNM1L_DANRE reviewed Dynamin-1-like protein (EC 3.6.5.5) dnm1l zgc:66163 Danio rerio (Zebrafish) (Brachydanio rerio) 691 dynamin polymerization involved in mitochondrial fission [GO:0003374]; mitochondrial fission [GO:0000266]; peroxisome fission [GO:0016559]; protein oligomerization [GO:0051259] GO:0000266; GO:0003374; GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005777; GO:0005794; GO:0005829; GO:0005905; GO:0008289; GO:0016559; GO:0030054; GO:0030672; GO:0042803; GO:0051259 0 0 0 PF01031;PF00350;PF02212; Q7SXW3 CHOYP_LRC40.1.2 m.20043 sp LRC40_DANRE 48.841 604 304 1 1 604 1 599 0 563 LRC40_DANRE reviewed Leucine-rich repeat-containing protein 40 lrrc40 zgc:63729 Danio rerio (Zebrafish) (Brachydanio rerio) 601 0 0 0 0 0 PF13855; Q7SY23 CHOYP_AL4A1.1.1 m.28988 sp AL4A1_DANRE 59.811 530 211 2 39 567 27 555 0 690 AL4A1_DANRE reviewed "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase)" aldh4a1 zgc:63592 Danio rerio (Zebrafish) (Brachydanio rerio) 556 glutamate biosynthetic process [GO:0006537]; proline biosynthetic process [GO:0006561]; proline catabolic process to glutamate [GO:0010133] GO:0003842; GO:0004029; GO:0005759; GO:0006537; GO:0006561; GO:0010133 PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. 0 cd07123; PF00171; Q7SY29 CHOYP_LOC100695416.1.1 m.51916 sp G6PT3_DANRE 55.728 515 202 8 1 510 1 494 0 550 G6PT3_DANRE reviewed Glucose-6-phosphate exchanger SLC37A2 (Solute carrier family 37 member 2) slc37a2 zgc:63583 Danio rerio (Zebrafish) (Brachydanio rerio) 494 anion transport [GO:0006820]; carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]; transmembrane transport [GO:0055085] GO:0006820; GO:0008643; GO:0015760; GO:0016021; GO:0022857; GO:0030176; GO:0035435; GO:0055085; GO:0061513 0 0 cd06174; PF07690; Q7SY48 CHOYP_HEAT1.1.1 m.11228 sp HEAT1_DANRE 33.473 1909 1086 56 1 1775 301 2159 0 859 HEAT1_DANRE reviewed HEAT repeat-containing protein 1 (Protein BAP28) heatr1 zgc:63510 Danio rerio (Zebrafish) (Brachydanio rerio) 2159 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription from RNA polymerase I promoter [GO:0045943]; regulation of RNA stability [GO:0043487]" GO:0000462; GO:0030515; GO:0030686; GO:0032040; GO:0034455; GO:0043066; GO:0043487; GO:0045943 0 0 0 PF08146;PF12397; Q7SZE5 CHOYP_SEC23B.1.1 m.12147 sp SC23A_DANRE 76.863 765 175 1 1 765 1 763 0 1256 SC23A_DANRE reviewed Protein transport protein Sec23A (SEC23-related protein A) sec23a Danio rerio (Zebrafish) (Brachydanio rerio) 765 cartilage development [GO:0051216]; embryonic neurocranium morphogenesis [GO:0048702]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; pectoral fin morphogenesis [GO:0035138] GO:0000139; GO:0006886; GO:0006888; GO:0008270; GO:0030127; GO:0030868; GO:0035138; GO:0048702; GO:0051216 0 0 0 PF00626;PF08033;PF04815;PF04811;PF04810; Q7T006 CHOYP_LOC588739.1.1 m.19304 sp TELO2_DANRE 38.372 774 451 7 69 829 55 815 0 556 TELO2_DANRE reviewed Telomere length regulation protein TEL2 homolog telo2 si:ch211-153c20.2 zgc:153824 Danio rerio (Zebrafish) (Brachydanio rerio) 822 0 GO:0005634; GO:0005737; GO:0016020 0 0 0 PF10193; Q7T0Q5 CHOYP_NOL10.1.1 m.1606 sp NOL10_XENLA 56.477 687 279 8 1 667 1 687 0 766 NOL10_XENLA reviewed Nucleolar protein 10 nol10 Xenopus laevis (African clawed frog) 689 0 GO:0005730 0 0 0 PF08159; Q7T0Y4 CHOYP_LOC575509.2.2 m.63548 sp DRC1_XENLA 52.295 719 296 9 62 779 14 686 0 682 DRC1_XENLA reviewed Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) drc1 ccdc164 Xenopus laevis (African clawed frog) 690 axonemal dynein complex assembly [GO:0070286]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cilium-dependent cell motility [GO:0060285] GO:0005737; GO:0005930; GO:0060285; GO:0070286; GO:0071973 0 0 0 PF14775; Q7T163 CHOYP_LOC100700010.1.1 m.57255 sp KDIS_DANRE 45.555 1271 602 23 32 1284 31 1229 0 1060 KDIS_DANRE reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) 1672 nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; regulation of protein kinase activity [GO:0045859] GO:0005770; GO:0007399; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0045859 0 0 0 PF00023;PF12796;PF07693; Q7TPH6 CHOYP_LOC100651327.1.1 m.34619 sp MYCB2_MOUSE 42.198 1192 531 32 1999 3147 2949 4025 0 754 MYCB2_MOUSE reviewed E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) Mycbp2 Pam Phr1 Mus musculus (Mouse) 4711 "branchiomotor neuron axon guidance [GO:0021785]; cell morphogenesis involved in neuron differentiation [GO:0048667]; central nervous system projection neuron axonogenesis [GO:0021952]; motor neuron axon guidance [GO:0008045]; negative regulation of protein catabolic process [GO:0042177]; protein ubiquitination [GO:0016567]; regulation of cytoskeleton organization [GO:0051493]; regulation of protein localization [GO:0032880]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008045; GO:0008270; GO:0015630; GO:0016020; GO:0016567; GO:0016874; GO:0021785; GO:0021952; GO:0030424; GO:0032880; GO:0042177; GO:0042803; GO:0048667; GO:0051493 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF00630;PF08005;PF00415;PF08239;PF13639; Q7TQ20 CHOYP_DNJC2.1.1 m.8941 sp DNJC2_RAT 51.603 624 279 9 1 614 1 611 0 595 DNJC2_RAT reviewed "DnaJ homolog subfamily C member 2 (Gliosarcoma-related antigen MIDA1) (Zuotin-related factor 1) [Cleaved into: DnaJ homolog subfamily C member 2, N-terminally processed]" Dnajc2 Mida1 Zrf1 Rattus norvegicus (Rat) 621 "covalent chromatin modification [GO:0016569]; negative regulation of cell growth [GO:0030308]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003682; GO:0005634; GO:0005829; GO:0006351; GO:0016569; GO:0030308; GO:0042393; GO:0043130; GO:0045893 0 0 cd06257; PF00226;PF00249;PF16717; Q7TQE6 CHOYP_BRAFLDRAFT_89952.1.1 m.59629 sp MACOI_MOUSE 53.176 677 251 16 1 627 1 661 0 627 MACOI_MOUSE reviewed Macoilin (Brain-specific adapter protein C61) (Transmembrane protein 57) Tmem57 Mus musculus (Mouse) 664 brain development [GO:0007420] GO:0005634; GO:0007420; GO:0016021; GO:0030424; GO:0031965; GO:0043005; GO:0044306; GO:0045202 0 0 0 PF09726; Q7TSH2 CHOYP_KPBB.2.2 m.46100 sp KPBB_MOUSE 51.39 1115 499 11 1 1102 1 1085 0 1121 KPBB_MOUSE reviewed Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) Phkb Mus musculus (Mouse) 1085 glycogen metabolic process [GO:0005977] GO:0004689; GO:0005886; GO:0005964; GO:0005977 PATHWAY: Glycan biosynthesis; glycogen metabolism. 0 0 PF00723; Q7YQM4 CHOYP_ATRX.1.1 m.14705 sp ATRX_PANTR 51.972 989 368 22 1039 1983 1477 2402 0 915 ATRX_PANTR reviewed Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) ATRX Pan troglodytes (Chimpanzee) 2492 "cellular response to hydroxyurea [GO:0072711]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; DNA replication-independent nucleosome assembly [GO:0006336]; negative regulation of telomeric RNA transcription from RNA pol II promoter [GO:1901581]; nucleosome assembly [GO:0006334]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of histone H3-K9 trimethylation [GO:1900112]; replication fork processing [GO:0031297]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003682; GO:0004386; GO:0005524; GO:0006281; GO:0006334; GO:0006336; GO:0006338; GO:0006351; GO:0010571; GO:0016569; GO:0016605; GO:0030330; GO:0031297; GO:0031933; GO:0032206; GO:0042393; GO:0045944; GO:0046872; GO:0070603; GO:0072711; GO:1900112; GO:1901581 0 0 0 PF00271;PF00176; Q7Z020 CHOYP_TRPA1.2.2 m.51663 sp TRPA1_DROME 42.542 1133 590 18 72 1147 59 1187 0 880 TRPA1_DROME reviewed Transient receptor potential cation channel subfamily A member 1 (dTRPA1) (Ankyrin-like with transmembrane domains protein 1) (dANKTM1) TrpA1 Anktm1 CG5751 Drosophila melanogaster (Fruit fly) 1197 calcium ion transport [GO:0006816]; cation transport [GO:0006812]; cellular response to heat [GO:0034605]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; mechanosensory behavior [GO:0007638]; negative phototaxis [GO:0046957]; neuronal signal transduction [GO:0023041]; phototransduction [GO:0007602]; positive regulation of calcium-mediated signaling [GO:0050850]; response to heat [GO:0009408]; response to light stimulus [GO:0009416]; sensory perception of pain [GO:0019233]; temperature compensation of the circadian clock [GO:0010378]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052] GO:0001580; GO:0005261; GO:0005886; GO:0006812; GO:0006816; GO:0007602; GO:0007638; GO:0009408; GO:0009416; GO:0010378; GO:0015276; GO:0016021; GO:0019233; GO:0023041; GO:0034605; GO:0034703; GO:0040040; GO:0043052; GO:0046957; GO:0050850; GO:0050960; GO:0050965; GO:0050968; GO:0097604 0 0 0 PF00023;PF12796;PF00520; Q7Z3U7 CHOYP_MON2.1.1 m.65761 sp MON2_HUMAN 55.28 1733 692 19 8 1679 7 1717 0 1826 MON2_HUMAN reviewed Protein MON2 homolog (Protein SF21) MON2 KIAA1040 SF21 Homo sapiens (Human) 1717 Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] GO:0005829; GO:0006895; GO:0015031; GO:0070062 0 0 0 PF16213;PF09324;PF16206;PF12783; Q7Z3V4 CHOYP_LOC659339.2.2 m.43302 sp UBE3B_HUMAN 52.495 1082 486 13 27 1094 1 1068 0 1152 UBE3B_HUMAN reviewed Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B) UBE3B Homo sapiens (Human) 1068 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005737; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q7Z401 CHOYP_DENND4A.1.1 m.342 sp MYCPP_HUMAN 55.1 902 386 9 5 891 8 905 0 1030 MYCPP_HUMAN reviewed C-myc promoter-binding protein (DENN domain-containing protein 4A) DENND4A IRLB MYCPBP Homo sapiens (Human) 1863 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0017112 0 0 0 PF03455;PF02141;PF03456; Q7Z460 CHOYP_CLAP1.6.6 m.57823 sp CLAP1_HUMAN 43.481 1534 650 30 4 1336 5 1522 0 1122 CLAP1_HUMAN reviewed CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) (Multiple asters homolog 1) (Protein Orbit homolog 1) (hOrbit1) CLASP1 KIAA0622 MAST1 Homo sapiens (Human) 1538 "astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of epithelial cell polarity [GO:0090162]; establishment of mitotic spindle localization [GO:0040001]; establishment of spindle orientation [GO:0051294]; establishment or maintenance of cell polarity [GO:0007163]; exit from mitosis [GO:0010458]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of microtubule polymerization [GO:0031116]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]; sister chromatid cohesion [GO:0007062]; vesicle targeting [GO:0006903]" GO:0000086; GO:0000226; GO:0000776; GO:0000777; GO:0001578; GO:0002162; GO:0005794; GO:0005813; GO:0005828; GO:0005829; GO:0005876; GO:0005881; GO:0005938; GO:0006903; GO:0007020; GO:0007026; GO:0007030; GO:0007052; GO:0007062; GO:0007163; GO:0008017; GO:0010458; GO:0010470; GO:0010634; GO:0010717; GO:0016020; GO:0030953; GO:0030981; GO:0031023; GO:0031111; GO:0031116; GO:0031592; GO:0034453; GO:0035371; GO:0040001; GO:0043515; GO:0045180; GO:0045921; GO:0051010; GO:0051294; GO:0051301; GO:0051497; GO:0051893; GO:0070062; GO:0070507; GO:0090091; GO:0090162; GO:0090307; GO:1903690; GO:1904261 0 0 0 PF12348; Q7Z4L5 CHOYP_BRAFLDRAFT_128460.1.2 m.7232 sp TT21B_HUMAN 56.489 1310 560 7 12 1315 10 1315 0 1559 TT21B_HUMAN reviewed Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) TTC21B KIAA1992 Nbla10696 Homo sapiens (Human) 1316 cilium morphogenesis [GO:0060271]; forebrain dorsal/ventral pattern formation [GO:0021798]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; protein localization to cilium [GO:0061512]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; smoothened signaling pathway [GO:0007224]; ventricular system development [GO:0021591] GO:0000790; GO:0005737; GO:0005856; GO:0005929; GO:0006357; GO:0007224; GO:0008589; GO:0021591; GO:0021798; GO:0030991; GO:0035721; GO:0035735; GO:0060271; GO:0061512; GO:0072372; GO:0097542 0 0 0 PF13181; Q7Z4S6 CHOYP_KI21A.2.2 m.47018 sp KI21A_HUMAN 46.424 1734 724 34 10 1619 6 1658 0 1407 KI21A_HUMAN reviewed Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) KIF21A KIAA1708 KIF2 Homo sapiens (Human) 1674 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF00225;PF00400; Q7Z4S6 CHOYP_KIF21A.1.1 m.24743 sp KI21A_HUMAN 46.185 1730 759 33 10 1645 6 1657 0 1411 KI21A_HUMAN reviewed Kinesin-like protein KIF21A (Kinesin-like protein KIF2) (Renal carcinoma antigen NY-REN-62) KIF21A KIAA1708 KIF2 Homo sapiens (Human) 1674 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF00225;PF00400; Q7Z569 CHOYP_BRAP.1.1 m.47862 sp BRAP_HUMAN 47.204 608 276 8 4 610 2 565 0 541 BRAP_HUMAN reviewed BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (Renal carcinoma antigen NY-REN-63) BRAP RNF52 Homo sapiens (Human) 592 MAPK cascade [GO:0000165]; negative regulation of signal transduction [GO:0009968]; protein ubiquitination [GO:0016567]; Ras protein signal transduction [GO:0007265] GO:0000151; GO:0000165; GO:0000166; GO:0004842; GO:0005737; GO:0005829; GO:0007265; GO:0008139; GO:0008270; GO:0009968; GO:0016567; GO:0016874; GO:0031965; GO:0042802; GO:0043130; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07576;PF13639;PF02148; Q7Z5J8 CHOYP_BRAFLDRAFT_75707.1.1 m.8533 sp ANKAR_HUMAN 41.016 1358 778 13 7 1358 8 1348 0 1019 ANKAR_HUMAN reviewed Ankyrin and armadillo repeat-containing protein ANKAR Homo sapiens (Human) 1434 0 GO:0005634; GO:0005737; GO:0016021 0 0 0 PF12796;PF00514; Q7Z6B7 CHOYP_LOC100169229.1.1 m.25981 sp SRGP1_HUMAN 46.641 789 377 10 34 790 24 800 0 707 SRGP1_HUMAN reviewed SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13) SRGAP1 ARHGAP13 KIAA1304 Homo sapiens (Human) 1085 negative regulation of cell migration [GO:0030336]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005737; GO:0005829; GO:0007165; GO:0030336; GO:0048365; GO:0051056 0 0 0 PF00611;PF00620;PF00018; Q7Z6Z7 CHOYP_HUWE1.1.2 m.566 sp HUWE1_HUMAN 51.459 2468 959 45 1 2330 1 2367 0 2325 HUWE1_HUMAN reviewed "E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) 4374 base-excision repair [GO:0006284]; cell differentiation [GO:0030154]; histone ubiquitination [GO:0016574]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006284; GO:0006513; GO:0016020; GO:0016574; GO:0016874; GO:0030154; GO:0042787; GO:0044822; GO:0070062; GO:1903955 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF14377;PF06012;PF06025;PF00632;PF00627;PF02825; Q7Z6Z7 CHOYP_HUWE1.2.2 m.39402 sp HUWE1_HUMAN 52.047 2467 979 44 1 2363 1 2367 0 2361 HUWE1_HUMAN reviewed "E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)" HUWE1 KIAA0312 KIAA1578 UREB1 HSPC272 Homo sapiens (Human) 4374 base-excision repair [GO:0006284]; cell differentiation [GO:0030154]; histone ubiquitination [GO:0016574]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006284; GO:0006513; GO:0016020; GO:0016574; GO:0016874; GO:0030154; GO:0042787; GO:0044822; GO:0070062; GO:1903955 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF14377;PF06012;PF06025;PF00632;PF00627;PF02825; Q7ZUW2 CHOYP_HYOU1.2.3 m.12568 sp HYOU1_DANRE 47.181 1011 472 15 9 1000 7 974 0 813 HYOU1_DANRE reviewed Hypoxia up-regulated protein 1 hyou1 Danio rerio (Zebrafish) (Brachydanio rerio) 980 0 GO:0005524; GO:0005788 0 0 0 PF00012; Q7ZVA6 CHOYP_IF4A3.1.1 m.30424 sp IF4A3_DANRE 90.274 401 38 1 72 471 6 406 0 766 IF4A3_DANRE reviewed Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) eif4a3 ddx48 Danio rerio (Zebrafish) (Brachydanio rerio) 406 "mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of gene expression [GO:0010468]; regulation of translation [GO:0006417]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]" GO:0000184; GO:0000381; GO:0003723; GO:0004004; GO:0005524; GO:0005737; GO:0006397; GO:0006417; GO:0008380; GO:0010468; GO:0010501; GO:0016607; GO:0051028; GO:0071013 0 0 0 PF00270;PF00271; Q7ZVL2 CHOYP_BRAFLDRAFT_60509.1.1 m.53067 sp WDR24_DANRE 43.363 791 397 16 14 770 6 779 0 647 WDR24_DANRE reviewed WD repeat-containing protein 24 wdr24 Danio rerio (Zebrafish) (Brachydanio rerio) 779 0 0 0 0 0 PF00400; Q7ZVR8 CHOYP_LOC659398.1.1 m.9611 sp ESRP2_DANRE 44.607 751 330 15 6 710 8 718 0 575 ESRP2_DANRE reviewed Epithelial splicing regulatory protein 2 (RNA-binding motif protein 35B) (RNA-binding protein 35B) esrp2 rbm35b zgc:77254 Danio rerio (Zebrafish) (Brachydanio rerio) 736 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003729; GO:0005634; GO:0006397; GO:0008380; GO:0043484 0 0 0 PF00076; Q7ZVY5 CHOYP_CISY.1.1 m.36666 sp CISY_DANRE 72.174 460 127 1 22 480 3 462 0 726 CISY_DANRE reviewed "Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)" cs zgc:55507 Danio rerio (Zebrafish) (Brachydanio rerio) 468 carbohydrate metabolic process [GO:0005975]; citrate metabolic process [GO:0006101]; response to activity [GO:0014823]; tricarboxylic acid cycle [GO:0006099] GO:0004108; GO:0005759; GO:0005975; GO:0006099; GO:0006101; GO:0014823 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. 0 0 PF00285; Q7ZW24 CHOYP_ALG11.1.1 m.39838 sp ALG11_DANRE 53.178 472 211 3 8 470 26 496 0 524 ALG11_DANRE reviewed "GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.131) (Asparagine-linked glycosylation protein 11 homolog) (Glycolipid 2-alpha-mannosyltransferase)" alg11 Danio rerio (Zebrafish) (Brachydanio rerio) 500 0 GO:0004377; GO:0016021 0 0 0 PF15924;PF00534; Q7ZWB7 CHOYP_BBS5.1.1 m.56560 sp BBS5_DANRE 77.778 342 74 1 17 356 1 342 0 575 BBS5_DANRE reviewed Bardet-Biedl syndrome 5 protein homolog bbs5 zgc:56578 Danio rerio (Zebrafish) (Brachydanio rerio) 342 cilium assembly [GO:0042384]; compound eye development [GO:0048749]; compound eye photoreceptor development [GO:0042051]; gastrulation [GO:0007369]; heart looping [GO:0001947]; intracellular transport [GO:0046907]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; pigment granule aggregation in cell center [GO:0051877]; pronephros formation [GO:0072116] GO:0001947; GO:0005737; GO:0007369; GO:0032266; GO:0032402; GO:0034464; GO:0036064; GO:0042051; GO:0042384; GO:0046907; GO:0048749; GO:0051877; GO:0060170; GO:0070121; GO:0072116 0 0 0 PF07289; Q7ZWS1 CHOYP_LOC100377501.1.1 m.13155 sp DUS3L_XENLA 58.855 559 203 8 99 651 103 640 0 681 DUS3L_XENLA reviewed tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) dus3l Xenopus laevis (African clawed frog) 640 0 GO:0017150; GO:0046872; GO:0050660 0 0 0 PF01207; Q7ZX96 CHOYP_BRAFLDRAFT_275527.1.1 m.12579 sp NUP93_XENLA 55.34 824 359 4 26 845 2 820 0 922 NUP93_XENLA reviewed Nuclear pore complex protein Nup93 (93 kDa nucleoporin) (An4a) (Nucleoporin Nup93) nup93 Xenopus laevis (African clawed frog) 820 mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; protein transport [GO:0015031] GO:0005643; GO:0015031; GO:0017056; GO:0031965; GO:0034399; GO:0051028; GO:0051292 0 0 0 PF04097; Q7ZXF1 CHOYP_BRAFLDRAFT_219160.1.1 m.58567 sp MTMR4_XENLA 37.692 1109 607 28 8 1064 2 1078 0 683 MTMR4_XENLA reviewed Myotubularin-related protein 4 (EC 3.1.3.48) mtmr4 Xenopus laevis (African clawed frog) 1078 transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0004722; GO:0004725; GO:0005737; GO:0007179; GO:0016020; GO:0046872 0 0 0 PF01363;PF06602; Q7ZXT3 CHOYP_LOC100374995.2.3 m.59062 sp EDC4_XENLA 32.692 1300 735 30 197 1426 157 1386 0 642 EDC4_XENLA reviewed Enhancer of mRNA-decapping protein 4 edc4 Xenopus laevis (African clawed frog) 1391 0 GO:0000932; GO:0005634 0 0 0 PF16529; Q7ZXX2 CHOYP_LOC100378372.1.1 m.53626 sp KIF19_XENLA 51.694 797 329 15 7 756 2 789 0 739 KIF19_XENLA reviewed Kinesin-like protein KIF19 kif19 Xenopus laevis (African clawed frog) 997 axonemal microtubule depolymerization [GO:0060404]; microtubule-based movement [GO:0007018]; plus-end specific microtubule depolymerization [GO:0070462] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0007018; GO:0008574; GO:0060404; GO:0070462 0 0 0 PF00225; Q7ZY18 CHOYP_BRAFLDRAFT_123986.1.1 m.47284 sp MC6ZB_XENLA 73.333 810 203 6 10 807 16 824 0 1228 MC6ZB_XENLA reviewed Zygotic DNA replication licensing factor mcm6-B (EC 3.6.4.12) (Zygotic minichromosome maintenance protein 6-B) (zMCM6-B) (zMCM6b) zmcm6-b zmcm6b Xenopus laevis (African clawed frog) 825 cell cycle [GO:0007049]; DNA replication initiation [GO:0006270]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0006270; GO:0007049; GO:0030174; GO:0042555; GO:0046872 0 0 0 PF00493;PF14551; Q7ZY47 CHOYP_DDX42.2.2 m.54450 sp DDX42_XENLA 63.18 717 248 7 3 707 4 716 0 900 DDX42_XENLA reviewed ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) ddx42 Xenopus laevis (African clawed frog) 947 0 GO:0003723; GO:0004386; GO:0005524; GO:0005634; GO:0005737 0 0 0 PF00270;PF00271; Q7ZY69 CHOYP_PESC.1.1 m.16875 sp PESC_XENLA 54.514 576 226 7 6 571 9 558 0 603 PESC_XENLA reviewed Pescadillo homolog pes1 Xenopus laevis (African clawed frog) 574 "cell proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" GO:0000463; GO:0000466; GO:0005654; GO:0005730; GO:0008283; GO:0030687; GO:0043021; GO:0070545 0 0 0 PF16589;PF06732; Q7ZYA0 CHOYP_LMBD2.1.1 m.14179 sp LMBD2_XENLA 47.613 733 348 8 1 717 1 713 0 711 LMBD2_XENLA reviewed LMBR1 domain-containing protein 2 lmbrd2 Xenopus laevis (African clawed frog) 713 0 GO:0016021 0 0 0 PF04791; Q7ZYC4 CHOYP_LOC100372454.1.1 m.56045 sp ACBG2_XENLA 55.781 640 278 3 87 721 88 727 0 728 ACBG2_XENLA reviewed Long-chain-fatty-acid--CoA ligase ACSBG2 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 2) acsbg2 Xenopus laevis (African clawed frog) 739 0 GO:0004467; GO:0005524; GO:0005737; GO:0102391 0 0 0 PF00501; Q7ZYD9 CHOYP_LOC100120406.1.1 m.31364 sp A13CB_XENLA 64.103 429 150 3 16 441 86 513 0 565 A13CB_XENLA reviewed Ankyrin repeat domain-containing protein 13C-B ankrd13c-b Xenopus laevis (African clawed frog) 513 0 GO:0005789 0 0 0 PF12796;PF11904; Q7ZYP6 CHOYP_MCMBP.1.2 m.3994 sp MCMBP_XENLA 49.559 567 263 8 14 566 1 558 0 543 MCMBP_XENLA reviewed Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) mcmbp Xenopus laevis (African clawed frog) 626 cell division [GO:0051301]; DNA-dependent DNA replication [GO:0006261]; mitotic nuclear division [GO:0007067]; sister chromatid cohesion [GO:0007062] GO:0003682; GO:0005634; GO:0006261; GO:0007062; GO:0007067; GO:0051301 0 0 0 PF09739; Q7ZYP6 CHOYP_MCMBP.2.2 m.18631 sp MCMBP_XENLA 49.357 622 296 6 1 610 1 615 0 590 MCMBP_XENLA reviewed Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein) mcmbp Xenopus laevis (African clawed frog) 626 cell division [GO:0051301]; DNA-dependent DNA replication [GO:0006261]; mitotic nuclear division [GO:0007067]; sister chromatid cohesion [GO:0007062] GO:0003682; GO:0005634; GO:0006261; GO:0007062; GO:0007067; GO:0051301 0 0 0 PF09739; Q801S2 CHOYP_DHSAB.1.1 m.25026 sp SDHAB_XENLA 74.887 665 166 1 913 1576 1 665 0 1041 SDHAB_XENLA reviewed "Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II B) (Fp)" sdha-b Xenopus laevis (African clawed frog) 665 respiratory electron transport chain [GO:0022904]; succinate metabolic process [GO:0006105]; tricarboxylic acid cycle [GO:0006099] GO:0005743; GO:0006099; GO:0006105; GO:0008177; GO:0022904; GO:0050660 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. {ECO:0000250|UniProtKB:P31040}. 0 0 PF00890;PF02910; Q802D3 CHOYP_XPO4.1.1 m.8526 sp XPO4_DANRE 47.213 1148 593 8 2 1140 7 1150 0 1099 XPO4_DANRE reviewed Exportin-4 xpo4 zgc:55678 Danio rerio (Zebrafish) (Brachydanio rerio) 1150 protein export from nucleus [GO:0006611] GO:0005049; GO:0005643; GO:0005737; GO:0006611; GO:0008536 0 0 0 PF08767; Q803A7 CHOYP_SPCS.1.1 m.65784 sp SPCS_DANRE 60.515 466 181 3 21 484 1 465 0 593 SPCS_DANRE reviewed O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (Soluble liver antigen/liver pancreas antigen-like) (UGA suppressor tRNA-associated protein homolog) sepsecs sla/lpl zgc:55980 Danio rerio (Zebrafish) (Brachydanio rerio) 490 selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; translation [GO:0006412] GO:0000049; GO:0005737; GO:0006412; GO:0016785; GO:0097056 PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2. {ECO:0000250|UniProtKB:Q9HD40}. 0 0 PF05889; Q803I2 CHOYP_ERGI3.1.1 m.16366 sp ERGI3_DANRE 69.816 381 112 2 9 389 6 383 0 576 ERGI3_DANRE reviewed Endoplasmic reticulum-Golgi intermediate compartment protein 3 ergic3 zgc:113959 zgc:55762 Danio rerio (Zebrafish) (Brachydanio rerio) 383 vesicle-mediated transport [GO:0016192] GO:0005789; GO:0005794; GO:0016021; GO:0016192; GO:0033116 0 0 0 PF07970; Q803R5 CHOYP_MTR1.1.1 m.59840 sp CMTR1_DANRE 52.875 800 357 10 27 822 41 824 0 828 CMTR1_DANRE reviewed Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (FtsJ methyltransferase domain-containing protein 2) cmtr1 ftsjd2 zgc:55336 Danio rerio (Zebrafish) (Brachydanio rerio) 829 7-methylguanosine mRNA capping [GO:0006370]; cap1 mRNA methylation [GO:0097309]; mRNA methylation [GO:0080009] GO:0003676; GO:0004483; GO:0005634; GO:0006370; GO:0080009; GO:0097309 0 0 0 PF01728;PF01585;PF00397; Q803X1 CHOYP_BRAFLDRAFT_127518.1.1 m.53432 sp CTU1_DANRE 77.015 335 72 3 1 330 1 335 0 551 CTU1_DANRE reviewed Cytoplasmic tRNA 2-thiolation protein 1 (EC 2.7.7.-) (ATP-binding domain-containing protein 3) (Cytoplasmic tRNA adenylyltransferase 1) ctu1 atpbd3 ncs6 zgc:55395 Danio rerio (Zebrafish) (Brachydanio rerio) 343 protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] GO:0000049; GO:0002098; GO:0005829; GO:0016779; GO:0032447; GO:0034227 PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03053}. 0 0 PF01171;PF16503; Q805F9 CHOYP_DDB1.1.1 m.59135 sp DDB1_CHICK 75.548 1141 276 3 1 1139 1 1140 0 1812 DDB1_CHICK reviewed DNA damage-binding protein 1 (DDB p127 subunit) (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor) DDB1 RCJMB04_6h2 Gallus gallus (Chicken) 1140 DNA repair [GO:0006281]; nucleotide-excision repair [GO:0006289]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] GO:0003684; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006289; GO:0016567; GO:0031461; GO:0031464; GO:0031465; GO:0043161; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:25043012}. 0 0 PF03178; Q80T85 CHOYP_DCAF5.1.1 m.39733 sp DCAF5_MOUSE 62.053 419 153 4 8 421 12 429 0 560 DCAF5_MOUSE reviewed DDB1- and CUL4-associated factor 5 (WD repeat-containing protein 22) Dcaf5 Kiaa1824 Wdr22 Mus musculus (Mouse) 946 protein ubiquitination [GO:0016567] GO:0005739; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q80TA9 CHOYP_EPG5.1.1 m.33917 sp EPG5_MOUSE 30.471 2376 1538 38 359 2671 244 2568 0 1140 EPG5_MOUSE reviewed Ectopic P granules protein 5 homolog Epg5 Kiaa1632 Mus musculus (Mouse) 2572 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endocytic recycling [GO:0032456] GO:0005737; GO:0006914; GO:0032456; GO:0097352 0 0 0 0 Q80TB7 CHOYP_ZSWM5.1.1 m.8996 sp ZSWM6_MOUSE 60.386 1035 373 7 90 1099 185 1207 0 1256 ZSWM6_MOUSE reviewed Zinc finger SWIM domain-containing protein 6 Zswim6 Kiaa1577 Mus musculus (Mouse) 1207 neuron projection morphogenesis [GO:0048812]; regulation of neuron migration [GO:2001222] GO:0008270; GO:0048812; GO:2001222 0 0 0 0 Q80TE4 CHOYP_SI1L1.1.2 m.7671 sp SI1L2_MOUSE 47.874 917 425 20 130 1021 152 1040 0 804 SI1L2_MOUSE reviewed Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) Sipa1l2 Kiaa0545 Mus musculus (Mouse) 1722 regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0051056 0 0 0 PF02145;PF11881; Q80TE4 CHOYP_SI1L1.2.2 m.60746 sp SI1L2_MOUSE 48.013 906 422 18 130 1011 152 1032 0 803 SI1L2_MOUSE reviewed Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2) Sipa1l2 Kiaa0545 Mus musculus (Mouse) 1722 regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0051056 0 0 0 PF02145;PF11881; Q80TP3 CHOYP_UBR5.1.1 m.44200 sp UBR5_MOUSE 46.763 2147 1010 48 1 2062 1 2099 0 1739 UBR5_MOUSE reviewed "E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog)" Ubr5 Edd Edd1 Kiaa0896 Mus musculus (Mouse) 2792 "cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of protein import into nucleus, translocation [GO:0033160]; progesterone receptor signaling pathway [GO:0050847]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]" GO:0000209; GO:0003723; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006974; GO:0008270; GO:0016020; GO:0016874; GO:0033160; GO:0034450; GO:0035413; GO:0042787; GO:0050847; GO:0090263; GO:1901315; GO:2000780 PATHWAY: Protein modification; protein ubiquitination. 0 cd14423; PF11547;PF00632;PF00658; Q80TS5 CHOYP_LOC100377260.1.1 m.11056 sp ZN423_MOUSE 31.263 1417 719 40 1 1287 1 1292 0 580 ZN423_MOUSE reviewed Zinc finger protein 423 (Early B-cell factor-associated zinc finger protein) (Olf1/EBF-associated zinc finger protein) (Smad- and Olf-interacting zinc finger protein) Znf423 Ebfaz Kiaa0760 Nur12 Oaz Zfp423 Mus musculus (Mouse) 1292 "cell differentiation [GO:0030154]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0007219; GO:0007399; GO:0030154; GO:0030513; GO:0045892; GO:0045893; GO:0046872 0 0 0 PF13912; Q80U30 CHOYP_LOC410511.2.2 m.57830 sp CL16A_MOUSE 59.489 822 298 10 31 825 1 814 0 971 CL16A_MOUSE reviewed Protein CLEC16A Clec16a Kiaa0350 Mus musculus (Mouse) 1036 autophagy [GO:0006914]; negative regulation of macromitophagy [GO:1901525]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of autophagosome maturation [GO:1901098] GO:0006914; GO:0032435; GO:0036020; GO:1901098; GO:1901525 0 0 0 PF09758; Q80U58 CHOYP_PUM1.1.1 m.8674 sp PUM2_MOUSE 69.592 490 123 11 533 1003 584 1066 0 645 PUM2_MOUSE reviewed Pumilio homolog 2 Pum2 Kiaa0235 Mus musculus (Mouse) 1066 positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of chromosome segregation [GO:0051983]; regulation of mRNA stability [GO:0043488]; stress granule assembly [GO:0034063] GO:0003723; GO:0003730; GO:0005737; GO:0010494; GO:0010608; GO:0031965; GO:0034063; GO:0043488; GO:0044822; GO:0048471; GO:0051983; GO:1900246; GO:2000637 0 0 cd07920; PF00806; Q80U95 CHOYP_UBE3C.1.1 m.56491 sp UBE3C_MOUSE 46.273 1100 543 20 1 1069 1 1083 0 920 UBE3C_MOUSE reviewed Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) Ube3c Kiaa0010 Kiaa10 Mus musculus (Mouse) 1083 protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0004842; GO:0005634; GO:0005737; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q80U96 CHOYP_XPO1.1.1 m.31560 sp XPO1_RAT 79.907 1075 210 4 3 1076 2 1071 0 1815 XPO1_RAT reviewed Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) Xpo1 Crm1 Rattus norvegicus (Rat) 1071 mRNA transport [GO:0051028]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of protein catabolic process [GO:0042176]; regulation of protein export from nucleus [GO:0046825]; response to drug [GO:0042493]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056] GO:0000055; GO:0000056; GO:0000122; GO:0000776; GO:0003723; GO:0005049; GO:0005634; GO:0005642; GO:0005730; GO:0005737; GO:0006611; GO:0010824; GO:0015030; GO:0019904; GO:0030529; GO:0031965; GO:0034504; GO:0042176; GO:0042493; GO:0046825; GO:0051028 0 0 0 PF08767;PF03810;PF08389; Q80UG8 CHOYP_LOC576625.1.1 m.26871 sp TTLL4_MOUSE 51.156 692 301 11 288 969 440 1104 0 701 TTLL4_MOUSE reviewed Tubulin polyglutamylase TTLL4 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 4) Ttll4 Kiaa0173 Mus musculus (Mouse) 1193 peptidyl-glutamic acid modification [GO:0018200]; protein polyglutamylation [GO:0018095] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0015631; GO:0018095; GO:0018200; GO:0070739 0 0 0 PF03133; Q80UM7 CHOYP_BRAFLDRAFT_247063.1.1 m.17671 sp MOGS_MOUSE 44.53 777 382 15 93 837 75 834 0 655 MOGS_MOUSE reviewed Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glucosidase 1) (Glycoprotein-processing glucosidase I) Mogs Gcs1 Mus musculus (Mouse) 834 oligosaccharide metabolic process [GO:0009311]; protein N-linked glycosylation [GO:0006487] GO:0004573; GO:0005789; GO:0006487; GO:0009311; GO:0016020; GO:0016021; GO:0070062 PATHWAY: Glycan metabolism; N-glycan degradation. 0 0 PF03200;PF16923; Q80V70 CHOYP_MEGF6.37.59 m.43401 sp MEGF6_MOUSE 43.38 1586 828 16 8 1569 18 1557 0 1244 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q80VY9 CHOYP_LOC101170865.1.1 m.11500 sp DHX33_MOUSE 61.442 638 244 2 28 664 56 692 0 844 DHX33_MOUSE reviewed Putative ATP-dependent RNA helicase DHX33 (EC 3.6.4.13) (DEAH box protein 33) Dhx33 Mus musculus (Mouse) 698 positive regulation of transcription from RNA polymerase I promoter [GO:0045943]; RNA processing [GO:0006396] GO:0000182; GO:0004004; GO:0005524; GO:0005654; GO:0005730; GO:0005737; GO:0006396; GO:0033613; GO:0044822; GO:0045943 0 0 0 PF00270;PF04408;PF00271;PF07717; Q80W54 CHOYP_FACE1.1.1 m.13875 sp FACE1_MOUSE 59.695 459 181 2 3 457 15 473 0 583 FACE1_MOUSE reviewed CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) Zmpste24 Face1 Mus musculus (Mouse) 475 CAAX-box protein processing [GO:0071586]; nuclear envelope organization [GO:0006998]; prenylated protein catabolic process [GO:0030327] GO:0004222; GO:0005637; GO:0005789; GO:0006998; GO:0016020; GO:0016021; GO:0030327; GO:0046872; GO:0070062; GO:0071586 0 0 0 PF01435;PF16491; Q80XI3 CHOYP_BRAFLDRAFT_277494.3.3 m.62602 sp IF4G3_MOUSE 44.262 1037 501 20 608 1613 589 1579 0 826 IF4G3_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Eif4g3 Mus musculus (Mouse) 1579 positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283] GO:0001934; GO:0003743; GO:0007283; GO:0044822; GO:0045727; GO:0060903 0 0 0 PF02847;PF02854;PF02020; Q80Y44 CHOYP_DDX10.1.1 m.17782 sp DDX10_MOUSE 49.195 870 385 10 64 897 25 873 0 768 DDX10_MOUSE reviewed Probable ATP-dependent RNA helicase DDX10 (EC 3.6.4.13) (DEAD box protein 10) Ddx10 Mus musculus (Mouse) 875 RNA secondary structure unwinding [GO:0010501] GO:0004004; GO:0005524; GO:0010501; GO:0044822 0 0 0 PF00270;PF13959;PF00271; Q80YA7 CHOYP_BRAFLDRAFT_92908.1.1 m.36182 sp DPP8_MOUSE 45.238 840 433 13 28 848 51 882 0 761 DPP8_MOUSE reviewed Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase VIII) (DPP VIII) Dpp8 Mus musculus (Mouse) 892 0 GO:0004177; GO:0005654; GO:0005737; GO:0008236 0 0 0 PF00930;PF00326; Q80ZA4 CHOYP_BRAFLDRAFT_108900.1.1 m.29890 sp PKHL1_MOUSE 39.31 898 512 17 2 888 3295 4170 0 649 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q80ZA4 CHOYP_BRAFLDRAFT_119774.4.4 m.33349 sp PKHL1_MOUSE 37.695 4234 2437 85 58 4182 32 4173 0 2744 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q80ZA4 CHOYP_PKHL1.3.3 m.42452 sp PKHL1_MOUSE 36.245 3984 2301 78 34 3879 32 3914 0 2367 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q80ZA5 CHOYP_S4A8.1.1 m.28334 sp S4A10_RAT 43.948 1008 504 19 75 1056 77 1049 0 830 S4A10_RAT reviewed Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) Slc4a10 Ncbe Rattus norvegicus (Rat) 1117 anion transmembrane transport [GO:0098656]; bicarbonate transport [GO:0015701]; nervous system development [GO:0007399]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005452; GO:0005887; GO:0006814; GO:0007399; GO:0008509; GO:0015293; GO:0015297; GO:0015701; GO:0051453; GO:0098656 0 0 0 PF07565;PF00955; Q810B6 CHOYP_LOC100372945.2.2 m.47110 sp ANFY1_MOUSE 56.877 1127 469 4 1 1112 44 1168 0 1341 ANFY1_MOUSE reviewed Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif) Ankfy1 Ankhzn Kiaa1255 Mus musculus (Mouse) 1169 "endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; endosome localization [GO:0032439]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005765; GO:0005769; GO:0005829; GO:0006897; GO:0010008; GO:0016020; GO:0016023; GO:0017137; GO:0030904; GO:0032439; GO:0034058; GO:0042147; GO:0044354; GO:0046872; GO:0048549; GO:0070062; GO:0090160; GO:1901981 0 0 0 PF00023;PF12796;PF00651;PF01363; Q810J8 CHOYP_LOC100375831.1.1 m.24502 sp ZFYV1_MOUSE 50.92 652 302 8 217 853 129 777 0 699 ZFYV1_MOUSE reviewed Zinc finger FYVE domain-containing protein 1 Zfyve1 Mus musculus (Mouse) 777 cellular response to starvation [GO:0009267]; macroautophagy [GO:0016236]; negative regulation of phosphatase activity [GO:0010923] GO:0000407; GO:0005545; GO:0005547; GO:0005776; GO:0005783; GO:0005795; GO:0009267; GO:0010923; GO:0016236; GO:0043325; GO:0044233; GO:0046872; GO:0048471; GO:0097629 0 0 0 PF01363; Q811L6 CHOYP_MAST4.1.1 m.25573 sp MAST4_MOUSE 46.739 1472 596 48 353 1748 108 1467 0 1024 MAST4_MOUSE reviewed Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1) Mast4 Mus musculus (Mouse) 2618 intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105] GO:0000287; GO:0004674; GO:0005524; GO:0005622; GO:0005737; GO:0018105; GO:0035556 0 0 0 PF08926;PF00595;PF00069; Q86SG6 CHOYP_LOC100375651.1.1 m.31317 sp NEK8_HUMAN 60.641 686 261 6 1 680 1 683 0 839 NEK8_HUMAN reviewed Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) NEK8 JCK NEK12A Homo sapiens (Human) 692 determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; organ morphogenesis [GO:0009887]; protein phosphorylation [GO:0006468]; regulation of hippo signaling [GO:0035330] GO:0004674; GO:0005524; GO:0005737; GO:0005856; GO:0005929; GO:0006468; GO:0007368; GO:0007507; GO:0009887; GO:0035330; GO:0046872; GO:0072372; GO:0097543; GO:0097546 0 0 0 PF00069;PF00415; Q86T65 CHOYP_LOC658864.1.1 m.50919 sp DAAM2_HUMAN 49.098 1053 508 11 7 1046 14 1051 0 960 DAAM2_HUMAN reviewed Disheveled-associated activator of morphogenesis 2 DAAM2 KIAA0381 Homo sapiens (Human) 1068 actin cytoskeleton organization [GO:0030036]; determination of left/right symmetry [GO:0007368] GO:0007368; GO:0030036; GO:0070062 0 0 0 PF06367;PF06371;PF02181; Q86UV5 CHOYP_UBP48.1.1 m.25564 sp UBP48_HUMAN 43.548 1116 511 21 1 1079 1 1034 0 867 UBP48_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific-processing protease 48) USP48 USP31 Homo sapiens (Human) 1035 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005654; GO:0005737; GO:0005739; GO:0006511; GO:0016579; GO:0045121; GO:0045211 0 0 0 PF00443; Q86VH2 CHOYP_LOC100373898.1.1 m.24900 sp KIF27_HUMAN 40 1450 726 21 9 1378 2 1387 0 983 KIF27_HUMAN reviewed Kinesin-like protein KIF27 KIF27 Homo sapiens (Human) 1401 cilium assembly [GO:0042384]; epithelial cilium movement [GO:0003351]; microtubule-based movement [GO:0007018]; ventricular system development [GO:0021591] GO:0003351; GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0005929; GO:0007018; GO:0016887; GO:0021591; GO:0042384; GO:0070062 0 0 0 PF00225; Q86VP3 CHOYP_BRAFLDRAFT_73177.1.1 m.61488 sp PACS2_HUMAN 40.044 899 426 25 10 823 14 884 0 568 PACS2_HUMAN reviewed Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) PACS2 KIAA0602 PACS1L Homo sapiens (Human) 889 apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; protein localization to pre-autophagosomal structure [GO:0034497]; protein targeting to plasma membrane [GO:0072661]; viral process [GO:0016032] GO:0000045; GO:0005739; GO:0005783; GO:0005788; GO:0006915; GO:0016032; GO:0034497; GO:0044325; GO:0072661 0 0 0 PF10254; Q86VS8 CHOYP_HOOK3.1.1 m.14456 sp HOOK3_HUMAN 55.05 703 301 6 1 690 7 707 0 722 HOOK3_HUMAN reviewed Protein Hook homolog 3 (h-hook3) (hHK3) HOOK3 Homo sapiens (Human) 718 cytoplasmic microtubule organization [GO:0031122]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; Golgi localization [GO:0051645]; interkinetic nuclear migration [GO:0022027]; lysosome organization [GO:0007040]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuronal stem cell population maintenance [GO:0097150]; protein localization to centrosome [GO:0071539]; protein transport [GO:0015031] GO:0000242; GO:0005737; GO:0005794; GO:0005801; GO:0005813; GO:0005815; GO:0005829; GO:0005874; GO:0007032; GO:0007040; GO:0008017; GO:0008333; GO:0015031; GO:0022027; GO:0031122; GO:0034451; GO:0034454; GO:0042802; GO:0045022; GO:0050768; GO:0051645; GO:0070695; GO:0071539; GO:0097150 0 0 0 PF05622; Q86VV8 CHOYP_RTTN.1.3 m.9025 sp RTTN_HUMAN 34.139 1365 831 26 4 1331 138 1471 0 710 RTTN_HUMAN reviewed Rotatin RTTN Homo sapiens (Human) 2226 cilium organization [GO:0044782]; determination of left/right symmetry [GO:0007368] GO:0005737; GO:0005813; GO:0007368; GO:0036064; GO:0044782 0 0 0 PF14726; Q86VV8 CHOYP_RTTN.2.3 m.17511 sp RTTN_HUMAN 31.083 1496 908 32 1 1422 777 2223 0 621 RTTN_HUMAN reviewed Rotatin RTTN Homo sapiens (Human) 2226 cilium organization [GO:0044782]; determination of left/right symmetry [GO:0007368] GO:0005737; GO:0005813; GO:0007368; GO:0036064; GO:0044782 0 0 0 PF14726; Q86VV8 CHOYP_RTTN.3.3 m.54096 sp RTTN_HUMAN 33.621 1389 825 26 1 1352 18 1346 0 692 RTTN_HUMAN reviewed Rotatin RTTN Homo sapiens (Human) 2226 cilium organization [GO:0044782]; determination of left/right symmetry [GO:0007368] GO:0005737; GO:0005813; GO:0007368; GO:0036064; GO:0044782 0 0 0 PF14726; Q86WI1 CHOYP_BRAFLDRAFT_119774.1.4 m.7149 sp PKHL1_HUMAN 41.356 1475 838 19 1 1464 1169 2627 0 1069 PKHL1_HUMAN reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) 4243 immune response [GO:0006955] GO:0004872; GO:0005615; GO:0005829; GO:0006955; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q86WI1 CHOYP_BRAFLDRAFT_119774.3.4 m.27677 sp PKHL1_HUMAN 40.463 2763 1522 45 4 2715 1479 4169 0 1965 PKHL1_HUMAN reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) 4243 immune response [GO:0006955] GO:0004872; GO:0005615; GO:0005829; GO:0006955; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q86WJ1 CHOYP_CHD1L.1.1 m.15962 sp CHD1L_HUMAN 52.921 873 378 16 23 888 36 882 0 901 CHD1L_HUMAN reviewed Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.12) (Amplified in liver cancer protein 1) CHD1L ALC1 Homo sapiens (Human) 897 "cellular response to DNA damage stimulus [GO:0006974]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]" GO:0000166; GO:0000717; GO:0003676; GO:0004003; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0006281; GO:0006293; GO:0006294; GO:0006295; GO:0006296; GO:0006338; GO:0006974; GO:0016887; GO:0033683; GO:0070911 0 0 0 PF00271;PF00176; Q86WU2 CHOYP_LOC100377100.1.1 m.51994 sp LDHD_HUMAN 55.094 481 193 1 35 492 27 507 0 563 LDHD_HUMAN reviewed "Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4)" LDHD Homo sapiens (Human) 507 0 GO:0004458; GO:0005739; GO:0005743; GO:0050660 0 0 0 PF02913;PF01565; Q86X10 CHOYP_BRAFLDRAFT_116449.1.1 m.36739 sp RLGPB_HUMAN 44.101 1551 759 33 1 1507 1 1487 0 1157 RLGPB_HUMAN reviewed Ral GTPase-activating protein subunit beta (p170) RALGAPB KIAA1219 Homo sapiens (Human) 1494 activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0046982; GO:0051056; GO:0090630 0 0 0 0 Q86XH1 CHOYP_IQCA1.1.3 m.4290 sp IQCA1_HUMAN 53.475 849 366 8 1 848 1 821 0 848 IQCA1_HUMAN reviewed IQ and AAA domain-containing protein 1 IQCA1 IQCA Homo sapiens (Human) 822 0 GO:0005524 0 0 0 PF00004; Q86XH1 CHOYP_IQCA1.3.3 m.57097 sp IQCA1_HUMAN 53.412 850 367 8 1 849 1 822 0 848 IQCA1_HUMAN reviewed IQ and AAA domain-containing protein 1 IQCA1 IQCA Homo sapiens (Human) 822 0 GO:0005524 0 0 0 PF00004; Q86XK2 CHOYP_LOC100882331.1.1 m.12074 sp FBX11_HUMAN 69.39 869 238 7 57 908 70 927 0 1229 FBX11_HUMAN reviewed F-box only protein 11 (Protein arginine N-methyltransferase 9) (Vitiligo-associated protein 1) (VIT-1) FBXO11 FBX11 PRMT9 VIT1 UG063H01 Homo sapiens (Human) 927 cellular protein modification process [GO:0006464]; protein ubiquitination [GO:0016567]; sensory perception of sound [GO:0007605]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0004842; GO:0005634; GO:0005694; GO:0005730; GO:0005737; GO:0006464; GO:0006511; GO:0007605; GO:0008270; GO:0016274; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF05048;PF02207; Q86XX4 CHOYP_FRAS1.2.4 m.20248 sp FRAS1_HUMAN 32.006 1231 789 19 6 1210 836 2044 0 634 FRAS1_HUMAN reviewed Extracellular matrix protein FRAS1 FRAS1 KIAA1500 Homo sapiens (Human) 4008 cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; palate development [GO:0060021]; protein transport [GO:0015031]; skin development [GO:0043588] GO:0002009; GO:0003338; GO:0005886; GO:0007154; GO:0015031; GO:0016021; GO:0030326; GO:0043588; GO:0046872; GO:0060021; GO:0061618 0 0 0 PF03160;PF00093; Q86XX4 CHOYP_FRAS1.4.4 m.53687 sp FRAS1_HUMAN 50.196 1534 727 15 6 1513 2362 3884 0 1519 FRAS1_HUMAN reviewed Extracellular matrix protein FRAS1 FRAS1 KIAA1500 Homo sapiens (Human) 4008 cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; palate development [GO:0060021]; protein transport [GO:0015031]; skin development [GO:0043588] GO:0002009; GO:0003338; GO:0005886; GO:0007154; GO:0015031; GO:0016021; GO:0030326; GO:0043588; GO:0046872; GO:0060021; GO:0061618 0 0 0 PF03160;PF00093; Q86XX4 CHOYP_LOC101076219.1.1 m.18543 sp FRAS1_HUMAN 43.353 865 466 8 2 856 1842 2692 0 695 FRAS1_HUMAN reviewed Extracellular matrix protein FRAS1 FRAS1 KIAA1500 Homo sapiens (Human) 4008 cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; palate development [GO:0060021]; protein transport [GO:0015031]; skin development [GO:0043588] GO:0002009; GO:0003338; GO:0005886; GO:0007154; GO:0015031; GO:0016021; GO:0030326; GO:0043588; GO:0046872; GO:0060021; GO:0061618 0 0 0 PF03160;PF00093; Q86YA3 CHOYP_LOC101359921.2.2 m.15986 sp ZGRF1_HUMAN 47.741 819 380 15 1525 2314 1265 2064 0 748 ZGRF1_HUMAN reviewed Protein ZGRF1 (GRF-type zinc finger domain-containing protein 1) ZGRF1 C4orf21 Homo sapiens (Human) 2104 0 GO:0008270; GO:0016021 0 0 0 PF10382;PF06839; Q86YA3 CHOYP_YD002.1.1 m.13057 sp ZGRF1_HUMAN 46.931 831 393 15 627 1428 1265 2076 0 735 ZGRF1_HUMAN reviewed Protein ZGRF1 (GRF-type zinc finger domain-containing protein 1) ZGRF1 C4orf21 Homo sapiens (Human) 2104 0 GO:0008270; GO:0016021 0 0 0 PF10382;PF06839; Q86YT6 CHOYP_MIB1.3.4 m.57545 sp MIB1_HUMAN 78.027 1024 176 9 11 1015 4 997 0 1637 MIB1_HUMAN reviewed E3 ubiquitin-protein ligase MIB1 (EC 6.3.2.-) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (Zinc finger ZZ type with ankyrin repeat domain protein 2) MIB1 DIP1 KIAA1323 ZZANK2 Homo sapiens (Human) 1006 blood vessel development [GO:0001568]; endocytosis [GO:0006897]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; somitogenesis [GO:0001756] GO:0001568; GO:0001701; GO:0001756; GO:0001841; GO:0001947; GO:0004842; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0006897; GO:0007219; GO:0008270; GO:0014069; GO:0016874; GO:0031410; GO:0045665; GO:0045807 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q86YW9 CHOYP_MD12L.1.1 m.1468 sp MD12L_HUMAN 44.726 1934 916 39 1 1848 1 1867 0 1499 MD12L_HUMAN reviewed Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like) MED12L KIAA1635 TNRC11L TRALP TRALPUSH PRO0314 Homo sapiens (Human) 2145 0 GO:0001105; GO:0016592 0 0 0 PF09497;PF12145;PF12144; Q8AV57 CHOYP_SDK2.1.1 m.7297 sp SDK2_CHICK 36.863 2219 1234 42 52 2176 32 2177 0 1288 SDK2_CHICK reviewed Protein sidekick-2 SDK2 Gallus gallus (Chicken) 2177 camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0016021; GO:0030054; GO:0042802; GO:0045202; GO:0060219 0 0 0 PF00041;PF07679; Q8AVG9 CHOYP_LOC583954.1.1 m.777 sp GATA_XENLA 58.683 501 192 3 1 493 1 494 0 604 GATA_XENLA reviewed "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1)" qrsl1 Xenopus laevis (African clawed frog) 524 glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543] GO:0005524; GO:0005739; GO:0030956; GO:0032543; GO:0050567; GO:0070681 0 0 0 PF01425; Q8AVM5 CHOYP_VPP1.2.2 m.13420 sp VPP1_XENLA 55.618 890 326 11 1 880 1 831 0 988 VPP1_XENLA reviewed V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) atp6v0a1 Xenopus laevis (African clawed frog) 831 ATP hydrolysis coupled proton transport [GO:0015991] GO:0000220; GO:0015078; GO:0015991; GO:0016021; GO:0030659; GO:0042470 0 0 0 PF01496; Q8AXY6 CHOYP_LOC100566968.1.1 m.15268 sp MUSK_CHICK 38.941 850 452 22 30 844 122 939 0 588 MUSK_CHICK reviewed "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Gallus gallus (Chicken) 947 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of synaptic growth at neuromuscular junction [GO:0008582] GO:0004714; GO:0005524; GO:0005886; GO:0007275; GO:0008582; GO:0016021; GO:0030054; GO:0030154; GO:0045211 0 0 0 PF01392;PF07679;PF00051;PF07714; Q8AY73 CHOYP_XPO2.1.1 m.50289 sp XPO2_ORENI 64.923 975 329 7 1 967 1 970 0 1272 XPO2_ORENI reviewed Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter) cse1l cas xpo2 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 971 body fluid secretion [GO:0007589]; intracellular protein transport [GO:0006886] GO:0005634; GO:0005737; GO:0006886; GO:0007589 0 0 0 PF03378;PF08506;PF03810; Q8AYS8 CHOYP_AGAP_AGAP003709.1.1 m.33773 sp KCMA1_CHICK 56.155 1113 398 13 13 1113 42 1076 0 1242 KCMA1_CHICK reviewed "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (cSlo)" KCNMA1 KCNMA Gallus gallus (Chicken) 1137 0 GO:0005249; GO:0008076; GO:0046872; GO:0060072 0 0 0 PF03493;PF00520; Q8AYS8 CHOYP_SLO1.1.1 m.29423 sp KCMA1_CHICK 56.857 1101 389 13 13 1093 42 1076 0 1249 KCMA1_CHICK reviewed "Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (cSlo)" KCNMA1 KCNMA Gallus gallus (Chicken) 1137 0 GO:0005249; GO:0008076; GO:0046872; GO:0060072 0 0 0 PF03493;PF00520; Q8BG19 CHOYP_TMTC4.1.1 m.6130 sp TMTC4_MOUSE 52.109 735 329 7 46 777 24 738 0 764 TMTC4_MOUSE reviewed Transmembrane and TPR repeat-containing protein 4 Tmtc4 Mus musculus (Mouse) 741 0 GO:0016021 0 0 0 PF08409;PF00515;PF13181; Q8BGQ7 CHOYP_SYAC.1.2 m.15846 sp SYAC_MOUSE 38.043 920 482 21 40 919 10 881 0 596 SYAC_MOUSE reviewed "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aars Mus musculus (Mouse) 968 alanyl-tRNA aminoacylation [GO:0006419]; cellular response to unfolded protein [GO:0034620]; cerebellar Purkinje cell layer development [GO:0021680]; endoplasmic reticulum unfolded protein response [GO:0030968]; hair follicle development [GO:0001942]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process [GO:0050905]; neuromuscular process controlling balance [GO:0050885]; protein folding [GO:0006457]; response to amino acid [GO:0043200]; skin development [GO:0043588]; tRNA modification [GO:0006400] GO:0000049; GO:0001942; GO:0002161; GO:0004813; GO:0005524; GO:0005737; GO:0005829; GO:0006400; GO:0006419; GO:0006457; GO:0008270; GO:0016020; GO:0016597; GO:0021680; GO:0030968; GO:0034620; GO:0043200; GO:0043524; GO:0043588; GO:0050885; GO:0050905; GO:0070062 0 0 0 PF02272;PF01411;PF07973; Q8BGQ7 CHOYP_SYAC.2.2 m.18500 sp SYAC_MOUSE 62.668 967 354 2 1 964 1 963 0 1277 SYAC_MOUSE reviewed "Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)" Aars Mus musculus (Mouse) 968 alanyl-tRNA aminoacylation [GO:0006419]; cellular response to unfolded protein [GO:0034620]; cerebellar Purkinje cell layer development [GO:0021680]; endoplasmic reticulum unfolded protein response [GO:0030968]; hair follicle development [GO:0001942]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process [GO:0050905]; neuromuscular process controlling balance [GO:0050885]; protein folding [GO:0006457]; response to amino acid [GO:0043200]; skin development [GO:0043588]; tRNA modification [GO:0006400] GO:0000049; GO:0001942; GO:0002161; GO:0004813; GO:0005524; GO:0005737; GO:0005829; GO:0006400; GO:0006419; GO:0006457; GO:0008270; GO:0016020; GO:0016597; GO:0021680; GO:0030968; GO:0034620; GO:0043200; GO:0043524; GO:0043588; GO:0050885; GO:0050905; GO:0070062 0 0 0 PF02272;PF01411;PF07973; Q8BGT5 CHOYP_LOC100164899.1.1 m.59665 sp ALAT2_MOUSE 57.322 478 202 2 3 479 45 521 0 604 ALAT2_MOUSE reviewed Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) Gpt2 Aat2 Mus musculus (Mouse) 522 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; L-alanine catabolic process [GO:0042853]; L-alanine metabolic process [GO:0042851] GO:0004021; GO:0005739; GO:0006103; GO:0009058; GO:0030170; GO:0042851; GO:0042853 PATHWAY: Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1. 0 0 PF00155; Q8BH24 CHOYP_TM9S4.1.1 m.23520 sp TM9S4_MOUSE 66.405 637 191 5 5 622 11 643 0 876 TM9S4_MOUSE reviewed Transmembrane 9 superfamily member 4 Tm9sf4 Kiaa0255 Mus musculus (Mouse) 643 0 GO:0016021 0 0 0 PF02990; Q8BH74 CHOYP_NU107.1.2 m.46092 sp NU107_MOUSE 44.699 915 470 15 44 935 24 925 0 768 NU107_MOUSE reviewed Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107) Nup107 Mus musculus (Mouse) 926 "mRNA export from nucleus [GO:0006406]; nuclear pore complex assembly [GO:0051292]; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000973]; protein import into nucleus [GO:0006606]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000777; GO:0000973; GO:0005487; GO:0005643; GO:0005654; GO:0005813; GO:0006355; GO:0006406; GO:0006606; GO:0016020; GO:0017056; GO:0031080; GO:0031965; GO:0034399; GO:0051292 0 0 0 PF04121; Q8BHG1 CHOYP_NRDC.1.1 m.28526 sp NRDC_MOUSE 42.5 960 537 8 118 1072 212 1161 0 791 NRDC_MOUSE reviewed Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase) Nrdc Nrd1 Mus musculus (Mouse) 1161 positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; protein processing [GO:0016485]; regulation of endopeptidase activity [GO:0052548] GO:0004222; GO:0005739; GO:0008233; GO:0008270; GO:0016485; GO:0051044; GO:0052548 0 0 0 PF00675;PF05193;PF16187; Q8BHI9 CHOYP_BRAFLDRAFT_70429.1.1 m.45103 sp NIM1_MOUSE 65.761 368 123 2 17 381 32 399 0 515 NIM1_MOUSE reviewed Serine/threonine-protein kinase NIM1 (EC 2.7.11.1) (NIM1 serine/threonine-protein kinase) Nim1k Nim1 Mus musculus (Mouse) 436 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0035556 0 0 0 PF00069; Q8BHJ5 CHOYP_AAEL_AAEL003539.1.1 m.16619 sp TBL1R_MOUSE 75.681 514 103 3 1 492 1 514 0 804 TBL1R_MOUSE reviewed F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) Tbl1xr1 Ira1 Tblr1 Mus musculus (Mouse) 514 "adipose tissue development [GO:0060612]; canonical Wnt signaling pathway [GO:0060070]; fat pad development [GO:0060613]; histone deacetylation [GO:0016575]; lipid catabolic process [GO:0016042]; multicellular organism growth [GO:0035264]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cAMP metabolic process [GO:0030814]; regulation of gene expression [GO:0010468]; regulation of triglyceride metabolic process [GO:0090207]; response to dietary excess [GO:0002021]; transcription, DNA-templated [GO:0006351]; white fat cell differentiation [GO:0050872]" GO:0000118; GO:0000122; GO:0002021; GO:0003677; GO:0003714; GO:0005634; GO:0005654; GO:0005876; GO:0006351; GO:0008013; GO:0010468; GO:0016042; GO:0016575; GO:0017053; GO:0030814; GO:0035264; GO:0042393; GO:0043161; GO:0044212; GO:0045892; GO:0045893; GO:0045944; GO:0047485; GO:0050872; GO:0060070; GO:0060612; GO:0060613; GO:0090207 0 0 0 PF08513;PF00400; Q8BHJ5 CHOYP_AAEL_AAEL003539.1.1 m.16620 sp TBL1R_MOUSE 75.681 514 103 3 1 492 1 514 0 804 TBL1R_MOUSE reviewed F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) Tbl1xr1 Ira1 Tblr1 Mus musculus (Mouse) 514 "adipose tissue development [GO:0060612]; canonical Wnt signaling pathway [GO:0060070]; fat pad development [GO:0060613]; histone deacetylation [GO:0016575]; lipid catabolic process [GO:0016042]; multicellular organism growth [GO:0035264]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cAMP metabolic process [GO:0030814]; regulation of gene expression [GO:0010468]; regulation of triglyceride metabolic process [GO:0090207]; response to dietary excess [GO:0002021]; transcription, DNA-templated [GO:0006351]; white fat cell differentiation [GO:0050872]" GO:0000118; GO:0000122; GO:0002021; GO:0003677; GO:0003714; GO:0005634; GO:0005654; GO:0005876; GO:0006351; GO:0008013; GO:0010468; GO:0016042; GO:0016575; GO:0017053; GO:0030814; GO:0035264; GO:0042393; GO:0043161; GO:0044212; GO:0045892; GO:0045893; GO:0045944; GO:0047485; GO:0050872; GO:0060070; GO:0060612; GO:0060613; GO:0090207 0 0 0 PF08513;PF00400; Q8BHJ9 CHOYP_LOC100374345.1.2 m.11328 sp SLU7_MOUSE 58.232 577 199 8 22 573 23 582 0 641 SLU7_MOUSE reviewed Pre-mRNA-splicing factor SLU7 Slu7 D11Ertd730e Mus musculus (Mouse) 585 "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA 3'-splice site recognition [GO:0000389]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000380; GO:0000386; GO:0000389; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006886; GO:0008270; GO:0016020; GO:0016607; GO:0030532; GO:0030628; GO:0034605; GO:0043231; GO:0071013 0 0 0 PF11708; Q8BHY3 CHOYP_AAEL_AAEL006656.1.1 m.37342 sp ANO1_MOUSE 42.65 898 418 17 77 914 52 912 0 721 ANO1_MOUSE reviewed Anoctamin-1 (Transmembrane protein 16A) Ano1 Tmem16a Mus musculus (Mouse) 960 cation transport [GO:0006812]; cellular response to heat [GO:0034605]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; iodide transport [GO:0015705]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of membrane potential [GO:0042391]; trachea development [GO:0060438] GO:0005227; GO:0005229; GO:0005247; GO:0005254; GO:0005737; GO:0005886; GO:0006812; GO:0006821; GO:0007200; GO:0009897; GO:0015111; GO:0015705; GO:0016324; GO:0034605; GO:0034707; GO:0035774; GO:0042391; GO:0042803; GO:0046982; GO:0050965; GO:0060438; GO:0070062; GO:1902476 0 0 0 PF16178;PF04547; Q8BI55 CHOYP_LOC100370831.1.1 m.53008 sp DYRK4_MOUSE 61.663 433 162 1 105 537 89 517 0 585 DYRK4_MOUSE reviewed Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) Dyrk4 Mus musculus (Mouse) 632 0 GO:0004674; GO:0004712; GO:0005524; GO:0005737; GO:0043231; GO:0046872 0 0 0 PF00069; Q8BI55 CHOYP_LOC579475.1.2 m.14329 sp DYRK4_MOUSE 61.894 433 161 1 112 544 89 517 0 587 DYRK4_MOUSE reviewed Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1) Dyrk4 Mus musculus (Mouse) 632 0 GO:0004674; GO:0004712; GO:0005524; GO:0005737; GO:0043231; GO:0046872 0 0 0 PF00069; Q8BIE6 CHOYP_FRM4B.1.1 m.2249 sp FRM4A_MOUSE 53.411 513 231 4 13 523 1 507 0 564 FRM4A_MOUSE reviewed FERM domain-containing protein 4A Frmd4a Frmd4 Kiaa1294 Mus musculus (Mouse) 1020 establishment of epithelial cell polarity [GO:0090162] GO:0005737; GO:0005856; GO:0005923; GO:0030674; GO:0090162 0 0 0 PF11819;PF09380;PF00373;PF09379; Q8BIK4 CHOYP_DOCK9.2.2 m.61635 sp DOCK9_MOUSE 44.68 2124 1021 39 24 2101 39 2054 0 1719 DOCK9_MOUSE reviewed Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) Dock9 D14Wsu89e Kiaa1058 Mus musculus (Mouse) 2055 small GTPase mediated signal transduction [GO:0007264] GO:0005089; GO:0005622; GO:0007264; GO:0012505; GO:0016020; GO:0017048 0 0 0 PF06920;PF14429;PF11878;PF00169; Q8BJ64 CHOYP_BRAFLDRAFT_235936.1.1 m.29814 sp CHDH_MOUSE 63.35 412 147 3 1 411 188 596 0 543 CHDH_MOUSE reviewed "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Mus musculus (Mouse) 596 glycine betaine biosynthetic process from choline [GO:0019285] GO:0005739; GO:0005743; GO:0008812; GO:0019285; GO:0050660 PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. 0 0 PF05199;PF00732; Q8BJ64 CHOYP_LOC100366344.1.1 m.7458 sp CHDH_MOUSE 67.611 565 175 5 632 1191 35 596 0 789 CHDH_MOUSE reviewed "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Mus musculus (Mouse) 596 glycine betaine biosynthetic process from choline [GO:0019285] GO:0005739; GO:0005743; GO:0008812; GO:0019285; GO:0050660 PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. 0 0 PF05199;PF00732; Q8BK63 CHOYP_KC1A.1.2 m.14719 sp KC1A_MOUSE 87.302 315 39 1 1 315 1 314 0 585 KC1A_MOUSE reviewed Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) Csnk1a1 Mus musculus (Mouse) 337 cell division [GO:0051301]; cell morphogenesis [GO:0000902]; Golgi organization [GO:0007030]; intermediate filament cytoskeleton organization [GO:0045104]; mitotic nuclear division [GO:0007067]; peptidyl-serine phosphorylation [GO:0018105]; phagocytosis [GO:0006909]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of GTP binding [GO:1904424]; Wnt signaling pathway [GO:0016055] GO:0000777; GO:0000902; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0006909; GO:0007030; GO:0007067; GO:0008360; GO:0016020; GO:0016055; GO:0016607; GO:0018105; GO:0030529; GO:0030877; GO:0032436; GO:0045104; GO:0051301; GO:0072372; GO:1904424 0 0 0 PF00069; Q8BKE9 CHOYP_LOC100378652.1.1 m.5656 sp IFT74_MOUSE 52.357 594 276 4 25 615 2 591 0 561 IFT74_MOUSE reviewed Intraflagellar transport protein 74 homolog (Capillary morphogenesis gene 1 protein) (CMG-1) (Coiled-coil domain-containing protein 2) Ift74 Ccdc2 Cmg1 Mus musculus (Mouse) 600 cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; epidermis development [GO:0008544]; heart development [GO:0007507]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; keratinocyte development [GO:0003334]; negative regulation of epithelial cell proliferation [GO:0050680]; Notch signaling pathway [GO:0007219]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003334; GO:0003682; GO:0005634; GO:0005813; GO:0005929; GO:0007219; GO:0007368; GO:0007507; GO:0008544; GO:0016023; GO:0030992; GO:0033630; GO:0035735; GO:0042073; GO:0042384; GO:0045944; GO:0048487; GO:0050680; GO:0060271; GO:0072372 0 0 0 0 Q8BKX6 CHOYP_SMG1.1.1 m.46694 sp SMG1_MOUSE 38.539 3695 1981 67 75 3589 74 3658 0 2449 SMG1_MOUSE reviewed Serine/threonine-protein kinase SMG1 (SMG-1) (EC 2.7.11.1) Smg1 Kiaa0421 Mus musculus (Mouse) 3658 "DNA repair [GO:0006281]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; peptidyl-serine phosphorylation [GO:0018105]; phosphatidylinositol phosphorylation [GO:0046854]; protein autophosphorylation [GO:0046777]; telomere maintenance [GO:0000723]" GO:0000184; GO:0000723; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006281; GO:0016301; GO:0018105; GO:0042162; GO:0044822; GO:0046777; GO:0046854; GO:0046872 0 0 0 PF02260;PF00454;PF15785; Q8BMF3 CHOYP_LOC100743251.1.1 m.16814 sp MAON_MOUSE 61.391 575 214 3 30 598 23 595 0 713 MAON_MOUSE reviewed "NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3)" Me3 Mus musculus (Mouse) 604 malate metabolic process [GO:0006108]; oxidation-reduction process [GO:0055114]; pyruvate metabolic process [GO:0006090] GO:0004470; GO:0004471; GO:0004473; GO:0005739; GO:0005759; GO:0006090; GO:0006108; GO:0008948; GO:0046872; GO:0051287; GO:0055114 0 0 0 PF00390;PF03949; Q8BR07 CHOYP_BICD2.1.1 m.9177 sp BICD1_MOUSE 42.705 843 412 13 10 799 9 833 0 547 BICD1_MOUSE reviewed Protein bicaudal D homolog 1 (Bic-D 1) Bicd1 Mus musculus (Mouse) 835 microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]; negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway [GO:1900737]; negative regulation of phospholipase C activity [GO:1900275]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein localization to organelle [GO:0033365]; regulation of proteinase activated receptor activity [GO:1900276]; stress granule assembly [GO:0034063]; viral process [GO:0016032] GO:0005794; GO:0005802; GO:0005829; GO:0005881; GO:0008093; GO:0016020; GO:0016032; GO:0017137; GO:0031410; GO:0031871; GO:0033365; GO:0034063; GO:0034452; GO:0045502; GO:0048260; GO:0048471; GO:0072385; GO:0072393; GO:0072517; GO:1900275; GO:1900276; GO:1900737 0 0 0 PF09730; Q8BR76 CHOYP_MKS3.1.1 m.62041 sp MKS3_MOUSE 39.897 975 529 22 38 982 45 992 0 694 MKS3_MOUSE reviewed Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67) Tmem67 Mks3 Mus musculus (Mouse) 992 branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; heart development [GO:0007507]; negative regulation of centrosome duplication [GO:0010826] GO:0005789; GO:0005813; GO:0007368; GO:0007507; GO:0010826; GO:0016021; GO:0030433; GO:0030659; GO:0031005; GO:0035869; GO:0036038; GO:0042384; GO:0048754; GO:0051082; GO:0060170; GO:0060271 0 0 0 PF09773; Q8BRC6 CHOYP_LOC100367205.1.1 m.24472 sp MAAT1_MOUSE 57.063 715 300 5 36 748 28 737 0 801 MAAT1_MOUSE reviewed Protein MAATS1 (AMY-1-associating protein expressed in testis 1 homolog) (AAT-1) (MYCBP/AMY-1-associated testis-expressed protein 1) Maats1 Aat1 Spata26 Mus musculus (Mouse) 783 0 GO:0005739 0 0 0 PF14738; Q8BRH0 CHOYP_BRAFLDRAFT_199459.1.1 m.16546 sp TMTC3_MOUSE 56.034 812 355 2 9 820 15 824 0 931 TMTC3_MOUSE reviewed Transmembrane and TPR repeat-containing protein 3 Tmtc3 Mus musculus (Mouse) 920 bud outgrowth involved in lung branching [GO:0060447]; cell differentiation [GO:0030154]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; muscle fiber development [GO:0048747]; post-embryonic development [GO:0009791]; regulation of gene expression [GO:0010468] GO:0009791; GO:0010468; GO:0016021; GO:0030154; GO:0030324; GO:0048286; GO:0048747; GO:0060447 0 0 0 PF08409;PF00515;PF13174;PF13181; Q8BRK9 CHOYP_MA2A2.1.1 m.8261 sp MA2A2_MOUSE 45.944 1171 585 17 21 1166 3 1150 0 1051 MA2A2_MOUSE reviewed "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" Man2a2 Mana2x Mus musculus (Mouse) 1152 mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein deglycosylation [GO:0006517] GO:0000139; GO:0004559; GO:0004572; GO:0006013; GO:0006491; GO:0006517; GO:0008270; GO:0015923; GO:0016021; GO:0016799; GO:0030246 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09261;PF01074;PF07748; Q8BS45 CHOYP_BRAFLDRAFT_60331.1.1 m.34512 sp IFT56_MOUSE 79.603 554 113 0 1 554 1 554 0 942 IFT56_MOUSE reviewed Intraflagellar transport protein 56 (Protein hop-sterile) (Tetratricopeptide repeat protein 26) (TPR repeat protein 26) Ttc26 Hop Ift56 Mus musculus (Mouse) 554 cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; photoreceptor cell differentiation [GO:0046530]; photoreceptor cell morphogenesis [GO:0008594]; smoothened signaling pathway [GO:0007224]; spermatid development [GO:0007286] GO:0005813; GO:0005929; GO:0007224; GO:0007286; GO:0008594; GO:0030992; GO:0036064; GO:0042073; GO:0042384; GO:0046530; GO:0072372 0 0 0 0 Q8BTF7 CHOYP_LIG4.1.1 m.6295 sp DNLI4_MOUSE 48.786 906 453 6 13 912 9 909 0 897 DNLI4_MOUSE reviewed DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4) Lig4 Mus musculus (Mouse) 911 "cell cycle [GO:0007049]; cell division [GO:0051301]; cell proliferation [GO:0008283]; cellular response to lithium ion [GO:0071285]; central nervous system development [GO:0007417]; chromosome organization [GO:0051276]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA ligation involved in DNA recombination [GO:0051102]; DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; immunoglobulin V(D)J recombination [GO:0033152]; in utero embryonic development [GO:0001701]; isotype switching [GO:0045190]; negative regulation of neuron apoptotic process [GO:0043524]; neuron apoptotic process [GO:0051402]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of chromosome organization [GO:2001252]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neurogenesis [GO:0050769]; pro-B cell differentiation [GO:0002328]; response to gamma radiation [GO:0010332]; response to ionizing radiation [GO:0010212]; response to X-ray [GO:0010165]; single strand break repair [GO:0000012]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077]; T cell receptor V(D)J recombination [GO:0033153]; V(D)J recombination [GO:0033151]" GO:0000012; GO:0000793; GO:0001701; GO:0002328; GO:0003677; GO:0003909; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0005925; GO:0005958; GO:0006260; GO:0006266; GO:0006281; GO:0006297; GO:0006302; GO:0006303; GO:0007049; GO:0007417; GO:0008022; GO:0008283; GO:0010165; GO:0010212; GO:0010332; GO:0016874; GO:0032807; GO:0033077; GO:0033151; GO:0033152; GO:0033153; GO:0035019; GO:0043524; GO:0045190; GO:0046872; GO:0048146; GO:0050769; GO:0051102; GO:0051103; GO:0051276; GO:0051301; GO:0051402; GO:0070419; GO:0071285; GO:0071897; GO:0097680; GO:2001252 0 0 0 PF00533;PF16589;PF04679;PF01068;PF04675;PF11411; Q8BTH8 CHOYP_KC1G3.2.2 m.23753 sp KC1G1_MOUSE 64.905 473 135 8 1 456 1 459 0 597 KC1G1_MOUSE reviewed Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1) Csnk1g1 Mus musculus (Mouse) 459 endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; regulation of cell shape [GO:0008360]; Wnt signaling pathway [GO:0016055] GO:0000287; GO:0001948; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006897; GO:0008360; GO:0016055; GO:0018105; GO:0042277; GO:0046777 0 0 0 PF12605;PF00069; Q8BTM8 CHOYP_FLNC.1.5 m.15149 sp FLNA_MOUSE 43.562 2431 1263 42 472 2833 256 2646 0 1785 FLNA_MOUSE reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Flna Fln Fln1 Mus musculus (Mouse) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; heart morphogenesis [GO:0003007]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001525; GO:0001664; GO:0001837; GO:0001948; GO:0001974; GO:0003007; GO:0003779; GO:0004871; GO:0005080; GO:0005634; GO:0005730; GO:0005737; GO:0005802; GO:0005829; GO:0005886; GO:0005903; GO:0005911; GO:0005925; GO:0005938; GO:0007195; GO:0008134; GO:0010977; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030036; GO:0030334; GO:0030426; GO:0031267; GO:0031523; GO:0031532; GO:0032231; GO:0032432; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042803; GO:0042993; GO:0043066; GO:0043113; GO:0043123; GO:0043433; GO:0044319; GO:0044822; GO:0045022; GO:0045184; GO:0045216; GO:0048365; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; Q8BTM8 CHOYP_FLNC.1.5 m.15150 sp FLNA_MOUSE 57.976 840 345 5 1 835 1810 2646 0 1004 FLNA_MOUSE reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Flna Fln Fln1 Mus musculus (Mouse) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; heart morphogenesis [GO:0003007]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001525; GO:0001664; GO:0001837; GO:0001948; GO:0001974; GO:0003007; GO:0003779; GO:0004871; GO:0005080; GO:0005634; GO:0005730; GO:0005737; GO:0005802; GO:0005829; GO:0005886; GO:0005903; GO:0005911; GO:0005925; GO:0005938; GO:0007195; GO:0008134; GO:0010977; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030036; GO:0030334; GO:0030426; GO:0031267; GO:0031523; GO:0031532; GO:0032231; GO:0032432; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042803; GO:0042993; GO:0043066; GO:0043113; GO:0043123; GO:0043433; GO:0044319; GO:0044822; GO:0045022; GO:0045184; GO:0045216; GO:0048365; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; Q8BTM8 CHOYP_contig_019041 m.22313 sp FLNA_MOUSE 43.521 2431 1250 43 460 2807 256 2646 0 1776 FLNA_MOUSE reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Flna Fln Fln1 Mus musculus (Mouse) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; heart morphogenesis [GO:0003007]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001525; GO:0001664; GO:0001837; GO:0001948; GO:0001974; GO:0003007; GO:0003779; GO:0004871; GO:0005080; GO:0005634; GO:0005730; GO:0005737; GO:0005802; GO:0005829; GO:0005886; GO:0005903; GO:0005911; GO:0005925; GO:0005938; GO:0007195; GO:0008134; GO:0010977; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030036; GO:0030334; GO:0030426; GO:0031267; GO:0031523; GO:0031532; GO:0032231; GO:0032432; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042803; GO:0042993; GO:0043066; GO:0043113; GO:0043123; GO:0043433; GO:0044319; GO:0044822; GO:0045022; GO:0045184; GO:0045216; GO:0048365; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; Q8BTW8 CHOYP_CK5P1.1.1 m.14748 sp CK5P1_MOUSE 57.658 555 212 6 57 606 45 581 0 639 CK5P1_MOUSE reviewed CDK5 regulatory subunit-associated protein 1 (CDK5 activator-binding protein C42) Cdk5rap1 Mus musculus (Mouse) 588 mitochondrial tRNA modification [GO:0070900]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of translational fidelity [GO:0045903]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of protein kinase activity [GO:0045859] GO:0000079; GO:0005739; GO:0019887; GO:0035597; GO:0045736; GO:0045859; GO:0045903; GO:0046872; GO:0051536; GO:0070131; GO:0070900 0 0 0 PF04055;PF01938;PF00919; Q8BVR6 CHOYP_LOC100881468.1.1 m.61700 sp RSPRY_MOUSE 51.473 577 263 5 1 566 1 571 0 595 RSPRY_MOUSE reviewed RING finger and SPRY domain-containing protein 1 Rspry1 Kiaa1972 Mus musculus (Mouse) 576 0 GO:0005576; GO:0008270 0 0 0 PF00622; Q8BW94 CHOYP_LOC587136.1.3 m.7607 sp DYH3_MOUSE 56.033 3978 1625 30 284 4224 193 4083 0 4370 DYH3_MOUSE reviewed "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (Ciliary dynein heavy chain 3)" Dnah3 Dnahc3 Mus musculus (Mouse) 4083 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0036156 0 0 0 PF12780;PF08393;PF03028;PF12777; Q8BW94 CHOYP_LOC587136.2.3 m.12221 sp DYH3_MOUSE 57.155 2292 925 18 2 2286 1842 4083 0 2677 DYH3_MOUSE reviewed "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (Ciliary dynein heavy chain 3)" Dnah3 Dnahc3 Mus musculus (Mouse) 4083 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0036156 0 0 0 PF12780;PF08393;PF03028;PF12777; Q8BWF0 CHOYP_POPTRDRAFT_1091519.1.1 m.56854 sp SSDH_MOUSE 56.576 479 204 2 88 564 47 523 0 561 SSDH_MOUSE reviewed "Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)" Aldh5a1 Mus musculus (Mouse) 523 acetate metabolic process [GO:0006083]; central nervous system development [GO:0007417]; galactosylceramide metabolic process [GO:0006681]; gamma-aminobutyric acid catabolic process [GO:0009450]; gamma-aminobutyric acid metabolic process [GO:0009448]; glucose metabolic process [GO:0006006]; glucosylceramide metabolic process [GO:0006678]; glutamate metabolic process [GO:0006536]; glutamine metabolic process [GO:0006541]; glutathione metabolic process [GO:0006749]; glycerophospholipid metabolic process [GO:0006650]; neurotransmitter catabolic process [GO:0042135]; oxidation-reduction process [GO:0055114]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; respiratory electron transport chain [GO:0022904]; short-chain fatty acid metabolic process [GO:0046459]; succinate metabolic process [GO:0006105] GO:0004029; GO:0004777; GO:0005739; GO:0006006; GO:0006083; GO:0006105; GO:0006536; GO:0006541; GO:0006650; GO:0006678; GO:0006681; GO:0006749; GO:0007417; GO:0009013; GO:0009448; GO:0009450; GO:0009791; GO:0022904; GO:0031406; GO:0042135; GO:0046459; GO:0051287; GO:0051289; GO:0055114 PATHWAY: Amino-acid degradation; 4-aminobutanoate degradation. 0 0 PF00171; Q8BWQ6 CHOYP_LOC594407.1.1 m.38463 sp CP062_MOUSE 56.983 981 392 8 10 978 1 963 0 1139 CP062_MOUSE reviewed UPF0505 protein C16orf62 homolog 0 Mus musculus (Mouse) 963 Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] GO:0005769; GO:0006893; GO:0015031; GO:0016021 0 0 0 0 Q8BX57 CHOYP_PXK.1.1 m.27815 sp PXK_MOUSE 56.092 476 205 1 1 472 1 476 0 548 PXK_MOUSE reviewed "PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)" Pxk Mus musculus (Mouse) 582 inflammatory response [GO:0006954]; modulation of synaptic transmission [GO:0050804]; negative regulation of ATPase activity [GO:0032780]; negative regulation of ion transport [GO:0043271]; regulation of membrane potential [GO:0042391] GO:0004672; GO:0005524; GO:0005634; GO:0005737; GO:0005815; GO:0005886; GO:0006954; GO:0008022; GO:0032780; GO:0035091; GO:0042391; GO:0043234; GO:0043271; GO:0050804 0 0 0 PF00069;PF00787;PF02205; Q8BX70 CHOYP_LOC100644563.1.1 m.56773 sp VP13C_MOUSE 32.313 1699 977 42 1 1647 2123 3700 0 780 VP13C_MOUSE reviewed Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) 3748 mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0005741; GO:0005829; GO:0006623; GO:0007005; GO:0019898; GO:0045053; GO:0070062; GO:1905090 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q8BY87 CHOYP_UBP47.1.2 m.66121 sp UBP47_MOUSE 47.886 1443 603 20 1 1361 1 1376 0 1284 UBP47_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) Usp47 Mus musculus (Mouse) 1376 "base-excision repair [GO:0006284]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell growth [GO:0030307]; response to drug [GO:0042493]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0004843; GO:0005634; GO:0005737; GO:0006284; GO:0006511; GO:0006974; GO:0010972; GO:0019005; GO:0030307; GO:0034644; GO:0035520; GO:0042493; GO:0043066; GO:0043154; GO:0045892; GO:0071987; GO:1902230 0 0 0 PF14560;PF00443; Q8BYH8 CHOYP_CHD7.1.2 m.4957 sp CHD9_MOUSE 52.367 1648 613 38 756 2359 495 2014 0 1653 CHD9_MOUSE reviewed Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Chd9 Kiaa0308 Pric320 Mus musculus (Mouse) 2885 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0016569 0 0 0 PF07533;PF00385;PF00271;PF00176; Q8BYH8 CHOYP_CHD7.2.2 m.14418 sp CHD9_MOUSE 53.255 1613 606 36 771 2341 508 2014 0 1659 CHD9_MOUSE reviewed Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) Chd9 Kiaa0308 Pric320 Mus musculus (Mouse) 2885 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0016569 0 0 0 PF07533;PF00385;PF00271;PF00176; Q8BZ00 CHOYP_SL9A7.1.2 m.40514 sp SL9A9_MOUSE 51.661 602 251 12 72 656 30 608 0 587 SL9A9_MOUSE reviewed Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) Slc9a9 Nhe9 Mus musculus (Mouse) 644 regulation of pH [GO:0006885] GO:0006885; GO:0015385; GO:0016021; GO:0031902; GO:0055037 0 0 0 PF00999; Q8BZ00 CHOYP_SL9A7.2.2 m.45572 sp SL9A9_MOUSE 50 620 256 12 81 687 30 608 0 583 SL9A9_MOUSE reviewed Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) Slc9a9 Nhe9 Mus musculus (Mouse) 644 regulation of pH [GO:0006885] GO:0006885; GO:0015385; GO:0016021; GO:0031902; GO:0055037 0 0 0 PF00999; Q8BZZ3 CHOYP_SUDX.1.1 m.4577 sp WWP1_MOUSE 56.229 907 298 12 52 866 19 918 0 1019 WWP1_MOUSE reviewed NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase WWP1) (WW domain-containing protein 1) Wwp1 Mus musculus (Mouse) 918 "lung development [GO:0030324]; negative regulation of transcription, DNA-templated [GO:0045892]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; T cell differentiation [GO:0030217]" GO:0004842; GO:0005634; GO:0005737; GO:0005886; GO:0016567; GO:0016874; GO:0030217; GO:0030324; GO:0042787; GO:0043161; GO:0045892; GO:0061630; GO:0070062 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00168;PF00632;PF00397; Q8C079 CHOYP_LOC100366965.1.2 m.40982 sp STRP1_MOUSE 59.722 792 314 3 18 806 47 836 0 929 STRP1_MOUSE reviewed Striatin-interacting protein 1 (Protein FAM40A) Strip1 Fam40a Kiaa1761 Mus musculus (Mouse) 837 cortical actin cytoskeleton organization [GO:0030866]; regulation of cell morphogenesis [GO:0022604] GO:0005634; GO:0005737; GO:0022604; GO:0030866; GO:0070062 0 0 0 PF11882;PF07923; Q8C0D5 CHOYP_EFTUD1.1.1 m.10474 sp EFL1_MOUSE 54.825 1140 447 15 12 1110 12 1124 0 1216 EFL1_MOUSE reviewed Elongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A) Efl1 Eftud1 Mus musculus (Mouse) 1127 mature ribosome assembly [GO:0042256] GO:0003924; GO:0005525; GO:0005622; GO:0042256; GO:0043022 0 0 0 PF00679;PF14492; Q8C0E2 CHOYP_ISCW_ISCW018536.1.1 m.56336 sp VP26B_MOUSE 73.451 339 80 3 1 334 1 334 0 511 VP26B_MOUSE reviewed Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) Vps26b Mus musculus (Mouse) 336 "intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005769; GO:0005770; GO:0005829; GO:0006886; GO:0008565; GO:0030904; GO:0042147 0 0 0 PF03643; Q8C0Y0 CHOYP_PPP4R4.1.3 m.31644 sp PP4R4_MOUSE 42.51 741 407 8 27 755 56 789 0 584 PP4R4_MOUSE reviewed Serine/threonine-protein phosphatase 4 regulatory subunit 4 Ppp4r4 Kiaa1622 Pp4r4 Mus musculus (Mouse) 875 negative regulation of phosphoprotein phosphatase activity [GO:0032515]; regulation of protein serine/threonine phosphatase activity [GO:0080163] GO:0005737; GO:0008287; GO:0019888; GO:0032515; GO:0080163 0 0 0 0 Q8C0Y0 CHOYP_PPP4R4.2.3 m.36245 sp PP4R4_MOUSE 44.256 766 396 11 14 765 24 772 0 629 PP4R4_MOUSE reviewed Serine/threonine-protein phosphatase 4 regulatory subunit 4 Ppp4r4 Kiaa1622 Pp4r4 Mus musculus (Mouse) 875 negative regulation of phosphoprotein phosphatase activity [GO:0032515]; regulation of protein serine/threonine phosphatase activity [GO:0080163] GO:0005737; GO:0008287; GO:0019888; GO:0032515; GO:0080163 0 0 0 0 Q8C0Y0 CHOYP_PPP4R4.3.3 m.58244 sp PP4R4_MOUSE 41.094 859 471 13 14 844 24 875 0 628 PP4R4_MOUSE reviewed Serine/threonine-protein phosphatase 4 regulatory subunit 4 Ppp4r4 Kiaa1622 Pp4r4 Mus musculus (Mouse) 875 negative regulation of phosphoprotein phosphatase activity [GO:0032515]; regulation of protein serine/threonine phosphatase activity [GO:0080163] GO:0005737; GO:0008287; GO:0019888; GO:0032515; GO:0080163 0 0 0 0 Q8C1A3 CHOYP_LOC100371498.1.1 m.10085 sp MTRR_MOUSE 42.605 737 371 16 6 732 2 696 0 562 MTRR_MOUSE reviewed Methionine synthase reductase (MSR) (EC 1.16.1.8) Mtrr Mus musculus (Mouse) 696 DNA methylation [GO:0006306]; folic acid metabolic process [GO:0046655]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; methionine biosynthetic process [GO:0009086]; negative regulation of cystathionine beta-synthase activity [GO:1904042]; oxidation-reduction process [GO:0055114]; protein stabilization [GO:0050821]; S-adenosylmethionine cycle [GO:0033353] GO:0003958; GO:0005654; GO:0005737; GO:0006306; GO:0009086; GO:0010181; GO:0016723; GO:0030586; GO:0033353; GO:0043418; GO:0045111; GO:0046655; GO:0047138; GO:0050444; GO:0050660; GO:0050667; GO:0050821; GO:0055114; GO:0070402; GO:0071949; GO:1904042 0 0 0 PF00667;PF00258;PF00175; Q8C1A5 CHOYP_THOP1.1.1 m.18269 sp THOP1_MOUSE 65.601 657 225 1 42 697 22 678 0 900 THOP1_MOUSE reviewed Thimet oligopeptidase (EC 3.4.24.15) Thop1 Mus musculus (Mouse) 687 intracellular signal transduction [GO:0035556]; peptide metabolic process [GO:0006518] GO:0004222; GO:0005758; GO:0006518; GO:0035556; GO:0046872 0 0 0 PF01432; Q8C2P3 CHOYP_VPP1.2.2 m.13421 sp DUS1L_MOUSE 58.515 458 181 5 9 461 3 456 0 555 DUS1L_MOUSE reviewed tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC 1.3.1.-) (tRNA-dihydrouridine synthase 1-like) Dus1l Mus musculus (Mouse) 475 0 GO:0005829; GO:0017150; GO:0050660 0 0 0 PF01207; Q8C3P7 CHOYP_PHUM_PHUM423190.1.1 m.18351 sp MTA70_MOUSE 52.74 584 219 11 24 571 15 577 0 595 MTA70_MOUSE reviewed N6-adenosine-methyltransferase subunit METTL3 (EC 2.1.1.62) (Methyltransferase-like protein 3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) Mettl3 Mta70 Mus musculus (Mouse) 580 "adenosine to inosine editing [GO:0006382]; circadian rhythm [GO:0007623]; mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cap-independent translational initiation [GO:1903679]; primary miRNA methylation [GO:1990744]; primary miRNA processing [GO:0031053]; RNA methylation [GO:0001510]; stem cell population maintenance [GO:0019827]" GO:0000398; GO:0001510; GO:0001734; GO:0003723; GO:0005634; GO:0006382; GO:0006397; GO:0007623; GO:0008173; GO:0016422; GO:0016556; GO:0016607; GO:0019827; GO:0031053; GO:0036396; GO:0061157; GO:0080009; GO:1903679; GO:1904047; GO:1990744 0 0 0 PF05063; Q8C3X4 CHOYP_GUF1.2.2 m.36316 sp GUF1_MOUSE 57.639 576 244 0 1 576 70 645 0 702 GUF1_MOUSE reviewed "Translation factor Guf1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase Guf1) (Ribosomal back-translocase)" Guf1 Mus musculus (Mouse) 651 positive regulation of translation [GO:0045727]; translation [GO:0006412] GO:0003924; GO:0005525; GO:0005739; GO:0005743; GO:0005759; GO:0006412; GO:0043022; GO:0045727 0 0 0 PF00679;PF03144;PF06421; Q8C4J7 CHOYP_LOC100707920.1.1 m.27511 sp TBL3_MOUSE 49.306 793 385 6 22 807 7 789 0 827 TBL3_MOUSE reviewed Transducin beta-like protein 3 Tbl3 Mus musculus (Mouse) 801 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" GO:0000462; GO:0005634; GO:0005730; GO:0030515; GO:0032040; GO:0034388; GO:0044822 0 0 0 PF08625;PF00400; Q8C5H1 CHOYP_TMEM16.1.2 m.24110 sp ANO4_MOUSE 45.302 894 436 14 70 939 82 946 0 755 ANO4_MOUSE reviewed Anoctamin-4 (Transmembrane protein 16D) Ano4 Tmem16d Mus musculus (Mouse) 955 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821] GO:0005622; GO:0005886; GO:0006821; GO:0016021; GO:0017128; GO:0061589; GO:0061590; GO:0061591; GO:1902476 0 0 0 PF16178;PF04547; Q8C6S9 CHOYP_LOC100370423.1.1 m.52513 sp CFA54_MOUSE 33 1900 1036 42 18 1882 110 1807 0 931 CFA54_MOUSE reviewed Cilia- and flagella-associated protein 54 Cfap54 Mus musculus (Mouse) 3106 cell differentiation [GO:0030154]; cilium assembly [GO:0042384]; cilium movement involved in cell motility [GO:0060294]; spermatogenesis [GO:0007283] GO:0005737; GO:0005930; GO:0007283; GO:0030154; GO:0042384; GO:0060294 0 0 0 PF14858; Q8C726 CHOYP_BRAFLDRAFT_93002.1.1 m.55566 sp BTBD9_MOUSE 59.391 591 238 2 1 591 1 589 0 771 BTBD9_MOUSE reviewed BTB/POZ domain-containing protein 9 Btbd9 Mus musculus (Mouse) 612 "adult locomotory behavior [GO:0008344]; circadian behavior [GO:0048512]; circadian sleep/wake cycle, non-REM sleep [GO:0042748]; long-term memory [GO:0007616]; multicellular organismal iron ion homeostasis [GO:0060586]; regulation of synaptic vesicle endocytosis [GO:1900242]; sensory perception of temperature stimulus [GO:0050951]; serotonin metabolic process [GO:0042428]" GO:0007616; GO:0008344; GO:0042428; GO:0042748; GO:0048512; GO:0050951; GO:0060586; GO:1900242 0 0 0 PF07707;PF00651;PF00754; Q8C7R4 CHOYP_UBA6.1.4 m.5773 sp UBA6_MOUSE 51.056 805 345 7 1 761 32 831 0 833 UBA6_MOUSE reviewed Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) Uba6 Ube1l2 Mus musculus (Mouse) 1053 amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004839; GO:0005524; GO:0005737; GO:0005829; GO:0006511; GO:0007612; GO:0007626; GO:0016567; GO:0019780; GO:0021764; GO:0021766; GO:0042787; GO:0060996 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P22314}. 0 0 PF16191;PF16190;PF09358;PF00899;PF10585; Q8C7R4 CHOYP_UBA6.3.4 m.53927 sp UBA6_MOUSE 54.652 1021 453 7 1 1016 32 1047 0 1156 UBA6_MOUSE reviewed Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) Uba6 Ube1l2 Mus musculus (Mouse) 1053 amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004839; GO:0005524; GO:0005737; GO:0005829; GO:0006511; GO:0007612; GO:0007626; GO:0016567; GO:0019780; GO:0021764; GO:0021766; GO:0042787; GO:0060996 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P22314}. 0 0 PF16191;PF16190;PF09358;PF00899;PF10585; Q8C7R7 CHOYP_LOC101075983.1.1 m.13076 sp RFX6_MOUSE 51.81 801 307 18 77 817 85 866 0 756 RFX6_MOUSE reviewed DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1) Rfx6 Rfxdc1 Mus musculus (Mouse) 927 "endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of insulin secretion [GO:0050796]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; type B pancreatic cell differentiation [GO:0003309]" GO:0000977; GO:0000978; GO:0001228; GO:0003309; GO:0003310; GO:0003311; GO:0003700; GO:0005634; GO:0006357; GO:0031018; GO:0035774; GO:0042593; GO:0044212; GO:0045893; GO:0045944; GO:0050796; GO:0090104 0 0 0 PF02257; Q8C878 CHOYP_UBA3.1.1 m.59856 sp UBA3_MOUSE 74.825 429 108 0 55 483 33 461 0 699 UBA3_MOUSE reviewed NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3) Uba3 Ube1c Mus musculus (Mouse) 462 "endomitotic cell cycle [GO:0007113]; mitotic cell cycle [GO:0000278]; negative regulation of transcription, DNA-templated [GO:0045892]; protein neddylation [GO:0045116]; regulation of cell cycle [GO:0051726]" GO:0000278; GO:0005524; GO:0005634; GO:0005829; GO:0007113; GO:0016881; GO:0019781; GO:0045116; GO:0045892; GO:0046982; GO:0051726 PATHWAY: Protein modification; protein neddylation. 0 0 PF08825;PF00899; Q8C8N2 CHOYP_ISCW_ISCW022658.1.2 m.6233 sp SCAI_MOUSE 56.483 563 231 9 35 593 53 605 0 647 SCAI_MOUSE reviewed Protein SCAI (Suppressor of cancer cell invasion protein) Scai Mus musculus (Mouse) 606 "negative regulation of cell migration [GO:0030336]; negative regulation of Rho protein signal transduction [GO:0035024]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003714; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016021; GO:0030336; GO:0031965; GO:0035024 0 0 0 PF12070; Q8C8N2 CHOYP_ISCW_ISCW022658.2.2 m.62886 sp SCAI_MOUSE 57.774 521 206 9 369 885 56 566 0 616 SCAI_MOUSE reviewed Protein SCAI (Suppressor of cancer cell invasion protein) Scai Mus musculus (Mouse) 606 "negative regulation of cell migration [GO:0030336]; negative regulation of Rho protein signal transduction [GO:0035024]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003714; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016021; GO:0030336; GO:0031965; GO:0035024 0 0 0 PF12070; Q8CCP0 CHOYP_NEMF.1.1 m.57807 sp NEMF_MOUSE 50.354 1130 451 23 1 1086 1 1064 0 976 NEMF_MOUSE reviewed Nuclear export mediator factor Nemf (Serologically defined colon cancer antigen 1 homolog) Nemf Sdccag1 Mus musculus (Mouse) 1064 nuclear export [GO:0051168] GO:0005634; GO:0051168 0 0 0 PF11923;PF05670; Q8CDK2 CHOYP_LOC100372232.1.6 m.2841 sp CBPC2_MOUSE 52.493 722 298 12 13 702 16 724 0 736 CBPC2_MOUSE reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) Agbl2 Ccp2 Mus musculus (Mouse) 862 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q8CDK2 CHOYP_LOC100372232.2.6 m.7169 sp CBPC2_MOUSE 52.493 722 301 11 13 705 16 724 0 739 CBPC2_MOUSE reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) Agbl2 Ccp2 Mus musculus (Mouse) 862 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q8CDK2 CHOYP_LOC100372232.3.6 m.17981 sp CBPC2_MOUSE 52.682 727 297 12 13 710 16 724 0 741 CBPC2_MOUSE reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) Agbl2 Ccp2 Mus musculus (Mouse) 862 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q8CDK2 CHOYP_LOC100372232.5.6 m.30079 sp CBPC2_MOUSE 54.074 675 282 8 38 703 69 724 0 721 CBPC2_MOUSE reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) Agbl2 Ccp2 Mus musculus (Mouse) 862 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q8CDK2 CHOYP_LOC100372232.6.6 m.45174 sp CBPC2_MOUSE 51.682 743 296 14 13 726 16 724 0 733 CBPC2_MOUSE reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) Agbl2 Ccp2 Mus musculus (Mouse) 862 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q8CEQ0 CHOYP_LOC100180636.1.1 m.66440 sp CDKL1_MOUSE 67.956 362 101 4 1 357 1 352 0 512 CDKL1_MOUSE reviewed Cyclin-dependent kinase-like 1 (EC 2.7.11.22) Cdkl1 Mus musculus (Mouse) 352 heart development [GO:0007507] GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0007507; GO:0070062 0 0 0 PF00069; Q8CF97 CHOYP_LOC100703289.1.1 m.53585 sp VCIP1_RAT 46.475 1220 562 22 13 1195 42 1207 0 1054 VCIP1_RAT reviewed Deubiquitinating protein VCIP135 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) Vcpip1 Vcip135 Rattus norvegicus (Rat) 1221 endoplasmic reticulum membrane fusion [GO:0016320]; Golgi organization [GO:0007030]; Golgi reassembly [GO:0090168]; mitotic nuclear division [GO:0007067]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567] GO:0004843; GO:0005783; GO:0005795; GO:0007030; GO:0007067; GO:0016320; GO:0016567; GO:0035871; GO:0071108; GO:0090168 0 0 0 PF02338; Q8CFH6 CHOYP_SIK2.1.1 m.59789 sp SIK2_MOUSE 48.015 806 342 26 1 779 1 756 0 622 SIK2_MOUSE reviewed Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) Sik2 Snf1lk2 Mus musculus (Mouse) 931 insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of insulin receptor signaling pathway [GO:0046626] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008286; GO:0035556; GO:0046626; GO:0046777 0 0 0 PF00069; Q8CFK2 CHOYP_BRF1.1.1 m.56369 sp TF3B_MOUSE 49.923 651 274 14 6 624 5 635 0 590 TF3B_MOUSE reviewed Transcription factor IIIB 90 kDa subunit (TFIIIB90) (mTFIIIB90) (B-related factor 1) (BRF-1) Brf1 Mus musculus (Mouse) 676 "regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]; transcription initiation from RNA polymerase III promoter [GO:0006384]" GO:0000126; GO:0006355; GO:0006384; GO:0008270; GO:0043488 0 0 0 PF07741;PF08271;PF00382; Q8CG09 CHOYP_MRP1.10.10 m.64931 sp MRP1_RAT 46.497 1570 782 19 4 1554 2 1532 0 1395 MRP1_RAT reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Mrp1 Rattus norvegicus (Rat) 1532 cell chemotaxis [GO:0060326]; daunorubicin transport [GO:0043215]; drug export [GO:0046618]; drug transmembrane transport [GO:0006855]; glutathione transmembrane transport [GO:0034775]; negative regulation of neuron death [GO:1901215]; phospholipid efflux [GO:0033700]; plasma membrane long-chain fatty acid transport [GO:0015911]; positive regulation of cell migration [GO:0030335]; response to drug [GO:0042493]; response to oxidative stress [GO:0006979]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908] GO:0005324; GO:0005524; GO:0005737; GO:0005886; GO:0005887; GO:0006855; GO:0006979; GO:0008559; GO:0015238; GO:0015431; GO:0015562; GO:0015911; GO:0016020; GO:0016323; GO:0016491; GO:0030335; GO:0033700; GO:0034040; GO:0034634; GO:0034775; GO:0042493; GO:0042908; GO:0043215; GO:0046618; GO:0046624; GO:0055085; GO:0060326; GO:1901215 0 0 0 PF00664;PF00005; Q8CG09 CHOYP_MRP1.5.10 m.34368 sp MRP1_RAT 48.925 1582 738 20 4 1566 2 1532 0 1486 MRP1_RAT reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Mrp1 Rattus norvegicus (Rat) 1532 cell chemotaxis [GO:0060326]; daunorubicin transport [GO:0043215]; drug export [GO:0046618]; drug transmembrane transport [GO:0006855]; glutathione transmembrane transport [GO:0034775]; negative regulation of neuron death [GO:1901215]; phospholipid efflux [GO:0033700]; plasma membrane long-chain fatty acid transport [GO:0015911]; positive regulation of cell migration [GO:0030335]; response to drug [GO:0042493]; response to oxidative stress [GO:0006979]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908] GO:0005324; GO:0005524; GO:0005737; GO:0005886; GO:0005887; GO:0006855; GO:0006979; GO:0008559; GO:0015238; GO:0015431; GO:0015562; GO:0015911; GO:0016020; GO:0016323; GO:0016491; GO:0030335; GO:0033700; GO:0034040; GO:0034634; GO:0034775; GO:0042493; GO:0042908; GO:0043215; GO:0046618; GO:0046624; GO:0055085; GO:0060326; GO:1901215 0 0 0 PF00664;PF00005; Q8CG46 CHOYP_SMC5.1.1 m.14393 sp SMC5_MOUSE 39.599 1048 615 5 32 1064 51 1095 0 787 SMC5_MOUSE reviewed Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (mSMC5) (Protein expressed in male leptotene and zygotene spermatocytes 453) (MLZ-453) Smc5 Kiaa0594 Smc5l1 Mus musculus (Mouse) 1101 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular senescence [GO:0090398]; double-strand break repair via homologous recombination [GO:0000724]; mitotic nuclear division [GO:0007067]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; resolution of recombination intermediates [GO:0071139]; sister chromatid cohesion [GO:0007062]; telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000724; GO:0000781; GO:0000803; GO:0005524; GO:0005634; GO:0005654; GO:0006974; GO:0007062; GO:0007067; GO:0016605; GO:0030054; GO:0030915; GO:0034184; GO:0035061; GO:0035861; GO:0045842; GO:0051301; GO:0051984; GO:0071139; GO:0090398 0 0 0 PF02463; Q8CGC7 CHOYP_EPRS.1.1 m.35443 sp SYEP_MOUSE 56.535 964 391 8 32 975 3 958 0 1083 SYEP_MOUSE reviewed Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)] Eprs Qprs Mus musculus (Mouse) 1512 cellular response to interferon-gamma [GO:0071346]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433] GO:0003723; GO:0004818; GO:0004827; GO:0005524; GO:0005737; GO:0006424; GO:0006433; GO:0016020; GO:0017101; GO:0017148; GO:0030529; GO:0035613; GO:0051020; GO:0071346; GO:0097452 0 0 cd00778; PF00043;PF03129;PF09180;PF00749;PF03950;PF00587;PF00458; Q8CGF6 CHOYP_WDR47.1.1 m.22342 sp WDR47_MOUSE 41.417 1002 483 20 5 993 6 916 0 694 WDR47_MOUSE reviewed WD repeat-containing protein 47 (Neuronal enriched MAP interacting protein) (Nemitin) Wdr47 Kiaa0893 Mus musculus (Mouse) 920 multicellular organism development [GO:0007275] GO:0005737; GO:0005874; GO:0007275 0 0 0 PF12894;PF00400; Q8CGF7 CHOYP_TCRG1.1.1 m.1150 sp TCRG1_MOUSE 53.566 715 253 7 475 1158 434 1100 0 698 TCRG1_MOUSE reviewed Transcription elongation regulator 1 (Formin-binding protein 28) (FBP 28) (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) (p144) Tcerg1 Taf2s Mus musculus (Mouse) 1100 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001103; GO:0001106; GO:0003700; GO:0005634; GO:0005730; GO:0006351; GO:0015629; GO:0044822; GO:0070064 0 0 0 PF01846;PF00397; Q8CGK3 CHOYP_LONM.1.1 m.7031 sp LONM_MOUSE 56.443 939 362 11 80 1010 41 940 0 1064 LONM_MOUSE reviewed "Lon protease homolog, mitochondrial (EC 3.4.21.-) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)" Lonp1 Prss15 Mus musculus (Mouse) 949 aging [GO:0007568]; cellular response to oxidative stress [GO:0034599]; chaperone-mediated protein complex assembly [GO:0051131]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrion organization [GO:0007005]; oxidation-dependent protein catabolic process [GO:0070407]; protein homooligomerization [GO:0051260]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of mitochondrial DNA replication [GO:0090296]; response to aluminum ion [GO:0010044]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666] GO:0001666; GO:0003697; GO:0003727; GO:0004176; GO:0004252; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005759; GO:0006508; GO:0006515; GO:0007005; GO:0007568; GO:0009725; GO:0010044; GO:0016020; GO:0016887; GO:0034599; GO:0042645; GO:0043531; GO:0043565; GO:0051131; GO:0051260; GO:0051603; GO:0051880; GO:0070182; GO:0070361; GO:0070407; GO:0090296 0 0 0 PF00004;PF05362;PF02190; Q8CGS6 CHOYP_BRAFLDRAFT_251779.1.2 m.6830 sp DPOLQ_MOUSE 44.529 786 374 10 513 1253 1776 2544 0 655 DPOLQ_MOUSE reviewed DNA polymerase theta (EC 2.7.7.7) (Chromosome aberrations occurring spontaneously protein 1) (DNA polymerase eta) Polq Chaos1 Mus musculus (Mouse) 2544 base-excision repair [GO:0006284]; cellular response to DNA damage stimulus [GO:0006974]; DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; protein homooligomerization [GO:0051260]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0003677; GO:0003682; GO:0003887; GO:0005524; GO:0005634; GO:0005694; GO:0006261; GO:0006281; GO:0006284; GO:0006302; GO:0006974; GO:0016446; GO:0043142; GO:0051260; GO:0051575; GO:0097681; GO:2000042 0 0 0 PF00270;PF00476;PF00271; Q8CHB8 CHOYP_LOC582217.1.1 m.16461 sp TTLL5_MOUSE 56.615 514 217 2 23 534 8 517 0 649 TTLL5_MOUSE reviewed Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 5) Ttll5 Kiaa0998 Mus musculus (Mouse) 1328 "fertilization [GO:0009566]; protein polyglutamylation [GO:0018095]; retina development in camera-type eye [GO:0060041]; spermatogenesis [GO:0007283]; sperm axoneme assembly [GO:0007288]; sperm motility [GO:0030317]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0005929; GO:0006351; GO:0007283; GO:0007288; GO:0009566; GO:0016874; GO:0018095; GO:0030317; GO:0060041 0 0 0 PF03133; Q8CHB8 CHOYP_contig_044341 m.51306 sp TTLL5_MOUSE 55.792 518 213 4 23 532 8 517 0 647 TTLL5_MOUSE reviewed Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 5) Ttll5 Kiaa0998 Mus musculus (Mouse) 1328 "fertilization [GO:0009566]; protein polyglutamylation [GO:0018095]; retina development in camera-type eye [GO:0060041]; spermatogenesis [GO:0007283]; sperm axoneme assembly [GO:0007288]; sperm motility [GO:0030317]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0005929; GO:0006351; GO:0007283; GO:0007288; GO:0009566; GO:0016874; GO:0018095; GO:0030317; GO:0060041 0 0 0 PF03133; Q8CHC4 CHOYP_SYNJ1.1.1 m.42275 sp SYNJ1_MOUSE 55.148 1117 451 15 1 1086 1 1098 0 1243 SYNJ1_MOUSE reviewed "Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)" Synj1 Kiaa0910 Mus musculus (Mouse) 1574 inositol phosphate dephosphorylation [GO:0046855]; learning [GO:0007612]; neurotransmitter transport [GO:0006836]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of endosome organization [GO:1904980]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; synaptic vesicle uncoating [GO:0016191] GO:0000166; GO:0003723; GO:0004438; GO:0004439; GO:0006836; GO:0007612; GO:0016082; GO:0016191; GO:0030117; GO:0030118; GO:0030132; GO:0034595; GO:0043812; GO:0046488; GO:0046855; GO:0046856; GO:0048015; GO:0048488; GO:0048489; GO:0097060; GO:0098793; GO:1904980 0 0 0 PF08952;PF03372;PF02383; Q8CHE4 CHOYP_BRAFLDRAFT_214316.1.1 m.7486 sp PHLP1_MOUSE 37.576 982 580 13 200 1171 424 1382 0 669 PHLP1_MOUSE reviewed PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) Phlpp1 Kiaa0606 Phlpp Plekhe1 Scop Mus musculus (Mouse) 1687 apoptotic process [GO:0006915]; entrainment of circadian clock [GO:0009649]; negative regulation of protein kinase B signaling [GO:0051898]; regulation of apoptotic process [GO:0042981]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of p38MAPK cascade [GO:1900744]; regulation of T cell anergy [GO:0002667] GO:0002667; GO:0004721; GO:0005634; GO:0005737; GO:0006915; GO:0009649; GO:0016020; GO:0042981; GO:0043408; GO:0046328; GO:0046872; GO:0051898; GO:1900744 0 0 0 PF13516;PF13855;PF00169;PF00481; Q8CHG5 CHOYP_CG4238.1.1 m.52609 sp AREL1_MOUSE 44.761 773 371 10 260 980 55 823 0 679 AREL1_MOUSE reviewed Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1) Arel1 Kiaa0317 Mus musculus (Mouse) 823 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0016874; GO:0042787; GO:0043066 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF00632; Q8CHG7 CHOYP_BRAFLDRAFT_131151.2.4 m.23262 sp RPGF2_MOUSE 44.073 1046 430 21 92 1004 67 1090 0 786 RPGF2_MOUSE reviewed Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) Rapgef2 Kiaa0313 Pdzgef1 Mus musculus (Mouse) 1496 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G-protein coupled receptor signaling pathway [GO:0007186]; microvillus assembly [GO:0030033]; negative regulation of cell proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; ventricular system development [GO:0021591] GO:0001568; GO:0001764; GO:0005088; GO:0005096; GO:0005737; GO:0005770; GO:0005829; GO:0005886; GO:0005911; GO:0005923; GO:0007186; GO:0007218; GO:0008285; GO:0010976; GO:0016020; GO:0016324; GO:0017034; GO:0019933; GO:0021591; GO:0021884; GO:0030033; GO:0030139; GO:0030165; GO:0030552; GO:0031175; GO:0031547; GO:0031697; GO:0032092; GO:0032486; GO:0038180; GO:0043005; GO:0043025; GO:0043234; GO:0043547; GO:0043950; GO:0045202; GO:0045860; GO:0048022; GO:0048167; GO:0048471; GO:0050699; GO:0050774; GO:0061028; GO:0070300; GO:0070374; GO:0071320; GO:0071321; GO:0071880; GO:0072659; GO:0090557; GO:1901888; GO:1990090; GO:2000481; GO:2000670; GO:2001214; GO:2001224 0 0 cd06224; PF00595;PF00788;PF00617;PF00618; Q8CHI8 CHOYP_LOC100115939.1.1 m.28155 sp EP400_MOUSE 38.21 1654 807 41 572 2179 965 2449 0 1030 EP400_MOUSE reviewed E1A-binding protein p400 (EC 3.6.4.-) (Domino homolog) (mDomino) (p400 kDa SWI2/SNF2-related protein) Ep400 Kiaa1498 Mus musculus (Mouse) 3072 histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967] GO:0000812; GO:0003677; GO:0003682; GO:0004386; GO:0005524; GO:0016607; GO:0035267; GO:0043967; GO:0043968 0 0 0 PF15790;PF00271;PF07529;PF00176; Q8CHN6 CHOYP_SGPL1.1.1 m.42223 sp SGPL1_RAT 51.356 553 251 8 71 612 14 559 0 592 SGPL1_RAT reviewed Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL) (SPL 1) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) Sgpl1 Spl Rattus norvegicus (Rat) 568 androgen metabolic process [GO:0008209]; apoptotic signaling pathway [GO:0097190]; ceramide metabolic process [GO:0006672]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; fatty acid metabolic process [GO:0006631]; fibroblast migration [GO:0010761]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; palate development [GO:0060021]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; regulation of multicellular organism growth [GO:0040014]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]; sphingolipid catabolic process [GO:0030149]; vasculogenesis [GO:0001570] GO:0001553; GO:0001570; GO:0001822; GO:0005789; GO:0006631; GO:0006672; GO:0007283; GO:0008117; GO:0008209; GO:0008210; GO:0009791; GO:0010761; GO:0016021; GO:0016831; GO:0030097; GO:0030149; GO:0030170; GO:0033327; GO:0040014; GO:0048008; GO:0048705; GO:0060021; GO:0060325; GO:0097190 PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:O95470}. 0 0 PF00282; Q8CJ27 CHOYP_ASPM.4.4 m.46677 sp ASPM_MOUSE 32.864 2909 1581 70 609 3246 313 3120 0 1264 ASPM_MOUSE reviewed Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein Sha1) (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein) Aspm Calmbp1 Sha1 Mus musculus (Mouse) 3122 brain development [GO:0007420]; cerebral cortex development [GO:0021987]; developmental growth [GO:0048589]; forebrain neuroblast division [GO:0021873]; maintenance of centrosome location [GO:0051661]; male gonad development [GO:0008584]; mitotic nuclear division [GO:0007067]; negative regulation of asymmetric cell division [GO:0045769]; negative regulation of neuron differentiation [GO:0045665]; neuronal stem cell population maintenance [GO:0097150]; neuron migration [GO:0001764]; oogenesis [GO:0048477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]; spindle assembly involved in meiosis [GO:0090306]; spindle localization [GO:0051653]; spindle organization [GO:0007051] GO:0000922; GO:0001764; GO:0002052; GO:0005516; GO:0005634; GO:0005737; GO:0005874; GO:0007051; GO:0007067; GO:0007283; GO:0007420; GO:0008584; GO:0021873; GO:0021987; GO:0030496; GO:0036449; GO:0045665; GO:0045769; GO:0048477; GO:0048589; GO:0051445; GO:0051653; GO:0051661; GO:0072687; GO:0090263; GO:0090306; GO:0097150; GO:0097431 0 0 0 PF15780;PF00307;PF00612; Q8CJF7 CHOYP_AHCTF1.1.1 m.17461 sp ELYS_MOUSE 33.209 1069 659 23 34 1089 39 1065 0 617 ELYS_MOUSE reviewed Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1) Ahctf1 Elys Mus musculus (Mouse) 2243 "cytokinesis [GO:0000910]; hemopoiesis [GO:0030097]; mitotic nuclear division [GO:0007067]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; protein transport [GO:0015031]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000777; GO:0000785; GO:0000910; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0007067; GO:0015031; GO:0016363; GO:0030097; GO:0031080; GO:0031965; GO:0051028; GO:0051292; GO:0070062 0 0 0 PF13934;PF16687; Q8CJG0 CHOYP_AGO1.1.1 m.16549 sp AGO2_MOUSE 76.214 803 191 0 33 835 58 860 0 1315 AGO2_MOUSE reviewed Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer) Ago2 Eif2c2 Kiaa4215 Mus musculus (Mouse) 860 "cell differentiation [GO:0030154]; gene silencing by RNA [GO:0031047]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; mRNA cleavage involved in gene silencing by miRNA [GO:0035279]; mRNA cleavage involved in gene silencing by siRNA [GO:0090625]; negative regulation of translational initiation [GO:0045947]; positive regulation of gene expression [GO:0010628]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; RNA secondary structure unwinding [GO:0010501]; siRNA loading onto RISC involved in RNA interference [GO:0035087]; transcription, DNA-templated [GO:0006351]" GO:0000340; GO:0000932; GO:0000993; GO:0001047; GO:0003723; GO:0003725; GO:0003727; GO:0003729; GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0005844; GO:0005845; GO:0006351; GO:0008022; GO:0009791; GO:0010501; GO:0010586; GO:0010628; GO:0016020; GO:0016442; GO:0030154; GO:0030425; GO:0030529; GO:0031047; GO:0031054; GO:0035068; GO:0035087; GO:0035196; GO:0035197; GO:0035198; GO:0035278; GO:0035279; GO:0035280; GO:0044822; GO:0045944; GO:0045947; GO:0046872; GO:0060213; GO:0070551; GO:0070578; GO:0090624; GO:0090625; GO:1900153 0 0 0 PF08699;PF16488;PF16487;PF16486;PF02170;PF02171; Q8CJG0 CHOYP_ISCW_ISCW013378.2.3 m.11858 sp AGO2_MOUSE 74.329 857 218 1 89 945 6 860 0 1352 AGO2_MOUSE reviewed Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer) Ago2 Eif2c2 Kiaa4215 Mus musculus (Mouse) 860 "cell differentiation [GO:0030154]; gene silencing by RNA [GO:0031047]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; mRNA cleavage involved in gene silencing by miRNA [GO:0035279]; mRNA cleavage involved in gene silencing by siRNA [GO:0090625]; negative regulation of translational initiation [GO:0045947]; positive regulation of gene expression [GO:0010628]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; RNA secondary structure unwinding [GO:0010501]; siRNA loading onto RISC involved in RNA interference [GO:0035087]; transcription, DNA-templated [GO:0006351]" GO:0000340; GO:0000932; GO:0000993; GO:0001047; GO:0003723; GO:0003725; GO:0003727; GO:0003729; GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0005844; GO:0005845; GO:0006351; GO:0008022; GO:0009791; GO:0010501; GO:0010586; GO:0010628; GO:0016020; GO:0016442; GO:0030154; GO:0030425; GO:0030529; GO:0031047; GO:0031054; GO:0035068; GO:0035087; GO:0035196; GO:0035197; GO:0035198; GO:0035278; GO:0035279; GO:0035280; GO:0044822; GO:0045944; GO:0045947; GO:0046872; GO:0060213; GO:0070551; GO:0070578; GO:0090624; GO:0090625; GO:1900153 0 0 0 PF08699;PF16488;PF16487;PF16486;PF02170;PF02171; Q8CJG0 CHOYP_ISCW_ISCW013378.3.3 m.20296 sp AGO2_MOUSE 74.419 860 216 1 57 916 5 860 0 1346 AGO2_MOUSE reviewed Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer) Ago2 Eif2c2 Kiaa4215 Mus musculus (Mouse) 860 "cell differentiation [GO:0030154]; gene silencing by RNA [GO:0031047]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; mRNA cleavage involved in gene silencing by miRNA [GO:0035279]; mRNA cleavage involved in gene silencing by siRNA [GO:0090625]; negative regulation of translational initiation [GO:0045947]; positive regulation of gene expression [GO:0010628]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; RNA secondary structure unwinding [GO:0010501]; siRNA loading onto RISC involved in RNA interference [GO:0035087]; transcription, DNA-templated [GO:0006351]" GO:0000340; GO:0000932; GO:0000993; GO:0001047; GO:0003723; GO:0003725; GO:0003727; GO:0003729; GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0005844; GO:0005845; GO:0006351; GO:0008022; GO:0009791; GO:0010501; GO:0010586; GO:0010628; GO:0016020; GO:0016442; GO:0030154; GO:0030425; GO:0030529; GO:0031047; GO:0031054; GO:0035068; GO:0035087; GO:0035196; GO:0035197; GO:0035198; GO:0035278; GO:0035279; GO:0035280; GO:0044822; GO:0045944; GO:0045947; GO:0046872; GO:0060213; GO:0070551; GO:0070578; GO:0090624; GO:0090625; GO:1900153 0 0 0 PF08699;PF16488;PF16487;PF16486;PF02170;PF02171; Q8CJG0 CHOYP_LOC100908241.1.1 m.52509 sp AGO2_MOUSE 71.645 857 240 2 77 932 6 860 0 1299 AGO2_MOUSE reviewed Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer) Ago2 Eif2c2 Kiaa4215 Mus musculus (Mouse) 860 "cell differentiation [GO:0030154]; gene silencing by RNA [GO:0031047]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; mRNA cleavage involved in gene silencing by miRNA [GO:0035279]; mRNA cleavage involved in gene silencing by siRNA [GO:0090625]; negative regulation of translational initiation [GO:0045947]; positive regulation of gene expression [GO:0010628]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; RNA secondary structure unwinding [GO:0010501]; siRNA loading onto RISC involved in RNA interference [GO:0035087]; transcription, DNA-templated [GO:0006351]" GO:0000340; GO:0000932; GO:0000993; GO:0001047; GO:0003723; GO:0003725; GO:0003727; GO:0003729; GO:0004521; GO:0005634; GO:0005737; GO:0005829; GO:0005844; GO:0005845; GO:0006351; GO:0008022; GO:0009791; GO:0010501; GO:0010586; GO:0010628; GO:0016020; GO:0016442; GO:0030154; GO:0030425; GO:0030529; GO:0031047; GO:0031054; GO:0035068; GO:0035087; GO:0035196; GO:0035197; GO:0035198; GO:0035278; GO:0035279; GO:0035280; GO:0044822; GO:0045944; GO:0045947; GO:0046872; GO:0060213; GO:0070551; GO:0070578; GO:0090624; GO:0090625; GO:1900153 0 0 0 PF08699;PF16488;PF16487;PF16486;PF02170;PF02171; Q8HZK2 CHOYP_DUOX1.1.4 m.14285 sp DUOX2_PIG 38.25 1634 853 34 28 1627 34 1545 0 1068 DUOX2_PIG reviewed Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (NADH/NADPH thyroid oxidase p138-tox) DUOX2 Sus scrofa (Pig) 1545 cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; oxidation-reduction process [GO:0055114]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] GO:0004601; GO:0005509; GO:0006590; GO:0006979; GO:0016021; GO:0016174; GO:0016324; GO:0019221; GO:0020037; GO:0030054; GO:0042335; GO:0042446; GO:0042744; GO:0050665; GO:0051591; GO:0055114 PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis. 0 0 PF03098;PF00036;PF13202;PF08022;PF01794;PF08030; Q8HZK2 CHOYP_DUOX1.2.4 m.33964 sp DUOX2_PIG 39.888 1612 853 34 6 1572 5 1545 0 1139 DUOX2_PIG reviewed Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (NADH/NADPH thyroid oxidase p138-tox) DUOX2 Sus scrofa (Pig) 1545 cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; oxidation-reduction process [GO:0055114]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] GO:0004601; GO:0005509; GO:0006590; GO:0006979; GO:0016021; GO:0016174; GO:0016324; GO:0019221; GO:0020037; GO:0030054; GO:0042335; GO:0042446; GO:0042744; GO:0050665; GO:0051591; GO:0055114 PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis. 0 0 PF03098;PF00036;PF13202;PF08022;PF01794;PF08030; Q8HZK2 CHOYP_DUOX1.4.4 m.44612 sp DUOX2_PIG 38.372 1634 851 34 28 1627 34 1545 0 1072 DUOX2_PIG reviewed Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (NADH/NADPH thyroid oxidase p138-tox) DUOX2 Sus scrofa (Pig) 1545 cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; hormone biosynthetic process [GO:0042446]; hydrogen peroxide biosynthetic process [GO:0050665]; hydrogen peroxide catabolic process [GO:0042744]; oxidation-reduction process [GO:0055114]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; thyroid hormone generation [GO:0006590] GO:0004601; GO:0005509; GO:0006590; GO:0006979; GO:0016021; GO:0016174; GO:0016324; GO:0019221; GO:0020037; GO:0030054; GO:0042335; GO:0042446; GO:0042744; GO:0050665; GO:0051591; GO:0055114 PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis. 0 0 PF03098;PF00036;PF13202;PF08022;PF01794;PF08030; Q8HZM5 CHOYP_LOC100376272.3.4 m.30522 sp GLNA_CANLF 71.111 360 104 0 2 361 3 362 0 572 GLNA_CANLF reviewed Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) GLUL Canis lupus familiaris (Dog) (Canis familiaris) 373 glutamine biosynthetic process [GO:0006542] GO:0004351; GO:0004356; GO:0005524; GO:0005739; GO:0006542 0 0 0 PF00120;PF03951; Q8HZM5 CHOYP_LOC100376272.4.4 m.50016 sp GLNA_CANLF 71.429 357 102 0 5 361 6 362 0 571 GLNA_CANLF reviewed Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) GLUL Canis lupus familiaris (Dog) (Canis familiaris) 373 glutamine biosynthetic process [GO:0006542] GO:0004351; GO:0004356; GO:0005524; GO:0005739; GO:0006542 0 0 0 PF00120;PF03951; Q8INB9 CHOYP_AKT1.2.2 m.51125 sp AKT1_DROME 63.2 500 139 5 10 474 107 596 0 639 AKT1_DROME reviewed RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Akt) (Protein kinase B) (PKB) Akt1 CG4006 Drosophila melanogaster (Fruit fly) 611 "apoptotic process [GO:0006915]; chitin-based embryonic cuticle biosynthetic process [GO:0008362]; circadian rhythm [GO:0007623]; dendrite regeneration [GO:0031104]; epithelial cell migration, open tracheal system [GO:0007427]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; long term synaptic depression [GO:0060292]; multicellular organism growth [GO:0035264]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron death [GO:1901215]; negative regulation of peptide hormone secretion [GO:0090278]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell growth [GO:0030307]; positive regulation of cell size [GO:0045793]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of organ growth [GO:0046622]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of dendrite development [GO:0050773]; regulation of glucose metabolic process [GO:0010906]; regulation of hemocyte proliferation [GO:0035206]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein import into nucleus [GO:0042306]; response to oxidative stress [GO:0006979]; somatic muscle development [GO:0007525]" GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0006629; GO:0006915; GO:0006979; GO:0007424; GO:0007427; GO:0007520; GO:0007525; GO:0007623; GO:0008286; GO:0008360; GO:0008361; GO:0008362; GO:0009986; GO:0010906; GO:0018105; GO:0019915; GO:0030307; GO:0031104; GO:0035091; GO:0035206; GO:0035264; GO:0035556; GO:0040014; GO:0040018; GO:0042306; GO:0043025; GO:0043066; GO:0045793; GO:0045886; GO:0046620; GO:0046622; GO:0048477; GO:0048680; GO:0050773; GO:0060292; GO:0090278; GO:1901215 0 0 0 PF00169;PF00069;PF00433; Q8INF0 CHOYP_SGCBETA-3.1.1 m.66126 sp GCY8E_DROME 53.571 644 255 6 1 644 1 600 0 699 GCY8E_DROME reviewed Soluble guanylate cyclase 88E (EC 4.6.1.2) Gyc88E CG4154 Drosophila melanogaster (Fruit fly) 947 cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; response to hypoxia [GO:0001666]; response to reactive oxygen species [GO:0000302]; signal transduction [GO:0007165] GO:0000302; GO:0001666; GO:0004383; GO:0005525; GO:0005886; GO:0006182; GO:0007165; GO:0008074; GO:0019825; GO:0019826; GO:0020037; GO:0035556; GO:0042803; GO:0046872; GO:0046982; GO:0070025; GO:0070026 0 0 0 PF00211;PF07700;PF07701; Q8IRG6 CHOYP_LOC100882621.1.2 m.25860 sp SPT16_DROME 59.871 1089 413 8 1 1072 1 1082 0 1313 SPT16_DROME reviewed FACT complex subunit spt16 (Facilitates chromatin transcription complex subunit SPT16) (dSPT16) dre4 spt16 CG1828 Drosophila melanogaster (Fruit fly) 1083 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; neurogenesis [GO:0022008]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; regulation of chromatin assembly or disassembly [GO:0001672]; transcription, DNA-templated [GO:0006351]" GO:0001672; GO:0003682; GO:0005634; GO:0005694; GO:0006260; GO:0006281; GO:0006351; GO:0022008; GO:0031491; GO:0032968; GO:0035101 0 0 0 PF14826;PF00557;PF08512;PF08644; Q8IRG6 CHOYP_LOC100882621.2.2 m.40306 sp SPT16_DROME 63.814 923 320 3 1 909 1 923 0 1255 SPT16_DROME reviewed FACT complex subunit spt16 (Facilitates chromatin transcription complex subunit SPT16) (dSPT16) dre4 spt16 CG1828 Drosophila melanogaster (Fruit fly) 1083 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; neurogenesis [GO:0022008]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; regulation of chromatin assembly or disassembly [GO:0001672]; transcription, DNA-templated [GO:0006351]" GO:0001672; GO:0003682; GO:0005634; GO:0005694; GO:0006260; GO:0006281; GO:0006351; GO:0022008; GO:0031491; GO:0032968; GO:0035101 0 0 0 PF14826;PF00557;PF08512;PF08644; Q8IUC8 CHOYP_GLT13.1.2 m.7888 sp GLT13_HUMAN 65.365 384 133 0 1 384 159 542 0 563 GLT13_HUMAN reviewed Polypeptide N-acetylgalactosaminyltransferase 13 (EC 2.4.1.41) (Polypeptide GalNAc transferase 13) (GalNAc-T13) (pp-GaNTase 13) (Protein-UDP acetylgalactosaminyltransferase 13) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13) GALNT13 KIAA1918 Homo sapiens (Human) 556 O-glycan processing [GO:0016266] GO:0000139; GO:0004653; GO:0016021; GO:0016266; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q8IUH5 CHOYP_ZDHHC17.1.1 m.29726 sp ZDH17_HUMAN 47.27 586 286 4 12 594 54 619 0 589 ZDH17_HUMAN reviewed Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) (DHHC-17) ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294 Homo sapiens (Human) 632 lipoprotein transport [GO:0042953]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein palmitoylation [GO:0018345] GO:0000139; GO:0004871; GO:0005737; GO:0005794; GO:0008270; GO:0015095; GO:0016021; GO:0016409; GO:0018345; GO:0019706; GO:0030054; GO:0030659; GO:0030660; GO:0042734; GO:0042802; GO:0042953; GO:0043123; GO:0043231 0 0 0 PF12796;PF01529; Q8IV36 CHOYP_LOC100374703.1.1 m.28348 sp HID1_HUMAN 70.681 822 201 7 1 816 1 788 0 1191 HID1_HUMAN reviewed Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) HID1 C17orf28 DMC1 Homo sapiens (Human) 788 intracellular protein transport [GO:0006886]; response to brefeldin A [GO:0031001] GO:0000138; GO:0005737; GO:0005794; GO:0005797; GO:0005881; GO:0006886; GO:0031001; GO:0070062; GO:0090498 0 0 0 0 Q8IV61 CHOYP_LOC100889329.1.1 m.65517 sp GRP3_HUMAN 47.962 638 276 14 67 673 8 620 0 583 GRP3_HUMAN reviewed Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1) RASGRP3 GRP3 KIAA0846 Homo sapiens (Human) 690 MAPK cascade [GO:0000165]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264] GO:0000165; GO:0004871; GO:0005085; GO:0005088; GO:0005096; GO:0005509; GO:0005886; GO:0005887; GO:0007264; GO:0007265; GO:0019992; GO:0032045; GO:0048471 0 0 cd06224; PF00130;PF13202;PF00617; Q8IVE3 CHOYP_PKHH2.1.1 m.7156 sp PKHH2_HUMAN 45.332 964 438 15 544 1482 546 1445 0 816 PKHH2_HUMAN reviewed Pleckstrin homology domain-containing family H member 2 PLEKHH2 KIAA2028 Homo sapiens (Human) 1493 negative regulation of actin filament depolymerization [GO:0030835] GO:0003779; GO:0005737; GO:0005886; GO:0030027; GO:0030835; GO:0030864 0 0 0 PF00373;PF00784;PF00169; Q8IVF4 CHOYP_LOC100374422.1.2 m.26376 sp DYH10_HUMAN 64.917 4552 1466 18 157 4702 45 4471 0 6123 DYH10_HUMAN reviewed "Dynein heavy chain 10, axonemal (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)" DNAH10 KIAA2017 Homo sapiens (Human) 4471 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0007018; GO:0016887; GO:0030286 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8IVF4 CHOYP_LOC100374422.2.2 m.52217 sp DYH10_HUMAN 65.42 4517 1466 18 157 4667 45 4471 0 6131 DYH10_HUMAN reviewed "Dynein heavy chain 10, axonemal (Axonemal beta dynein heavy chain 10) (Ciliary dynein heavy chain 10)" DNAH10 KIAA2017 Homo sapiens (Human) 4471 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0007018; GO:0016887; GO:0030286 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8IVL1 CHOYP_LOC100377223.1.1 m.53641 sp NAV2_HUMAN 66.29 442 131 6 90 524 2034 2464 0 632 NAV2_HUMAN reviewed Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) 2488 glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564] GO:0003025; GO:0004386; GO:0005524; GO:0005614; GO:0005654; GO:0007605; GO:0007608; GO:0007626; GO:0008201; GO:0021554; GO:0021563; GO:0021564 0 0 0 PF00307; Q8IVL1 CHOYP_NAV2.1.3 m.9737 sp NAV2_HUMAN 53.972 856 309 19 1597 2431 1667 2458 0 826 NAV2_HUMAN reviewed Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) 2488 glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564] GO:0003025; GO:0004386; GO:0005524; GO:0005614; GO:0005654; GO:0007605; GO:0007608; GO:0007626; GO:0008201; GO:0021554; GO:0021563; GO:0021564 0 0 0 PF00307; Q8IVL1 CHOYP_NAV2.2.3 m.18799 sp NAV2_HUMAN 54.756 862 305 19 1349 2189 1667 2464 0 843 NAV2_HUMAN reviewed Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) 2488 glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564] GO:0003025; GO:0004386; GO:0005524; GO:0005614; GO:0005654; GO:0007605; GO:0007608; GO:0007626; GO:0008201; GO:0021554; GO:0021563; GO:0021564 0 0 0 PF00307; Q8IVL1 CHOYP_NAV2.3.3 m.39879 sp NAV2_HUMAN 58.127 769 285 14 1598 2341 1667 2423 0 840 NAV2_HUMAN reviewed Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2) NAV2 HELAD1 KIAA1419 POMFIL2 RAINB1 STEERIN2 Homo sapiens (Human) 2488 glossopharyngeal nerve development [GO:0021563]; locomotory behavior [GO:0007626]; optic nerve development [GO:0021554]; regulation of systemic arterial blood pressure by baroreceptor feedback [GO:0003025]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; vagus nerve development [GO:0021564] GO:0003025; GO:0004386; GO:0005524; GO:0005614; GO:0005654; GO:0007605; GO:0007608; GO:0007626; GO:0008201; GO:0021554; GO:0021563; GO:0021564 0 0 0 PF00307; Q8IWF2 CHOYP_HX1.1.1 m.23716 sp FXRD2_HUMAN 53.81 630 264 8 16 622 15 640 0 672 FXRD2_HUMAN reviewed FAD-dependent oxidoreductase domain-containing protein 2 (Endoplasmic reticulum flavoprotein associated with degradation) FOXRED2 ERFAD Homo sapiens (Human) 684 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; oxidation-reduction process [GO:0055114] GO:0001948; GO:0004497; GO:0005788; GO:0030433; GO:0050660; GO:0055114 0 0 0 0 Q8IWG1 CHOYP_WDR63.1.1 m.21743 sp WDR63_HUMAN 49.017 865 415 9 84 941 35 880 0 850 WDR63_HUMAN reviewed WD repeat-containing protein 63 (Testis development protein NYD-SP29) WDR63 Homo sapiens (Human) 891 0 0 0 0 0 0 Q8IWY4 CHOYP_SCUB1.1.1 m.52452 sp SCUB1_HUMAN 46.362 962 488 14 56 1001 35 984 0 854 SCUB1_HUMAN reviewed "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) 988 adult heart development [GO:0007512]; blood coagulation [GO:0007596]; endothelial cell differentiation [GO:0045446]; inflammatory response [GO:0006954]; post-embryonic development [GO:0009791]; protein homooligomerization [GO:0051260] GO:0005509; GO:0005615; GO:0006954; GO:0007512; GO:0007596; GO:0009791; GO:0009897; GO:0009986; GO:0019897; GO:0042802; GO:0045446; GO:0046982; GO:0051260 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q8IY37 CHOYP_LOC101173065.1.1 m.11998 sp DHX37_HUMAN 59.057 933 359 8 239 1158 233 1155 0 1110 DHX37_HUMAN reviewed Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37) DHX37 DDX37 KIAA1517 Homo sapiens (Human) 1157 RNA processing [GO:0006396]; rRNA processing [GO:0006364] GO:0004004; GO:0005524; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0006396; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF07717; Q8IYD8 CHOYP_BRAFLDRAFT_118736.1.1 m.17458 sp FANCM_HUMAN 49.148 822 361 14 4 799 3 793 0 780 FANCM_HUMAN reviewed Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog) FANCM KIAA1596 Homo sapiens (Human) 2048 interstrand cross-link repair [GO:0036297]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] GO:0000712; GO:0003677; GO:0003682; GO:0004386; GO:0004518; GO:0005524; GO:0005654; GO:0031297; GO:0036297; GO:0043240; GO:0071821 0 0 0 PF02732;PF16783;PF00271;PF04851; Q8IYE0 CHOYP_CCDC146.1.1 m.11347 sp CC146_HUMAN 43.516 933 526 1 28 960 24 955 0 709 CC146_HUMAN reviewed Coiled-coil domain-containing protein 146 CCDC146 KIAA1505 Homo sapiens (Human) 955 0 GO:0005814 0 0 0 0 Q8IYW2 CHOYP_LOC100374785.1.3 m.20017 sp CFA46_HUMAN 40.818 1051 541 10 350 1399 288 1258 0 782 CFA46_HUMAN reviewed Cilia- and flagella-associated protein 46 (Tetratricopeptide repeat protein 40) CFAP46 C10orf123 C10orf124 C10orf92 C10orf93 TTC40 Homo sapiens (Human) 2715 axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] GO:0005737; GO:0005930; GO:0035082; GO:0060294 0 0 0 0 Q8IYW2 CHOYP_LOC100374785.2.3 m.34677 sp CFA46_HUMAN 32.996 2467 1328 43 16 2395 292 2520 0 1188 CFA46_HUMAN reviewed Cilia- and flagella-associated protein 46 (Tetratricopeptide repeat protein 40) CFAP46 C10orf123 C10orf124 C10orf92 C10orf93 TTC40 Homo sapiens (Human) 2715 axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] GO:0005737; GO:0005930; GO:0035082; GO:0060294 0 0 0 0 Q8IYW2 CHOYP_LOC100374785.3.3 m.47184 sp CFA46_HUMAN 33.347 2453 1327 45 1 2365 288 2520 0 1191 CFA46_HUMAN reviewed Cilia- and flagella-associated protein 46 (Tetratricopeptide repeat protein 40) CFAP46 C10orf123 C10orf124 C10orf92 C10orf93 TTC40 Homo sapiens (Human) 2715 axoneme assembly [GO:0035082]; cilium movement involved in cell motility [GO:0060294] GO:0005737; GO:0005930; GO:0035082; GO:0060294 0 0 0 0 Q8IZ69 CHOYP_TRMT2A.1.1 m.17768 sp TRM2A_HUMAN 47.898 547 264 5 86 629 60 588 0 547 TRM2A_HUMAN reviewed tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.-) (HpaII tiny fragments locus 9c protein) TRMT2A HTF9C Homo sapiens (Human) 625 RNA processing [GO:0006396] GO:0000166; GO:0006396; GO:0008173; GO:0044822 0 0 0 PF05958; Q8IZD9 CHOYP_DOCK3.2.2 m.59250 sp DOCK3_HUMAN 36.675 1955 1099 42 6 1907 2 1870 0 1118 DOCK3_HUMAN reviewed Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) DOCK3 KIAA0299 MOCA Homo sapiens (Human) 2030 small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005737; GO:0007264 0 0 0 PF06920;PF14429;PF16172;PF07653; Q8IZH2 CHOYP_LOC100369596.1.1 m.7021 sp XRN1_HUMAN 54.561 1206 496 16 1 1183 1 1177 0 1290 XRN1_HUMAN reviewed 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog) XRN1 SEP1 Homo sapiens (Human) 1706 histone mRNA catabolic process [GO:0071044]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; regulation of mRNA stability [GO:0043488]; rRNA catabolic process [GO:0016075] GO:0000956; GO:0003677; GO:0004527; GO:0005634; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0016020; GO:0016075; GO:0043488; GO:0044822; GO:0045111; GO:0071028; GO:0071044 0 0 0 PF03159; Q8IZU2 CHOYP_WDR17.1.1 m.17546 sp WDR17_HUMAN 51.994 1304 593 14 2 1281 28 1322 0 1402 WDR17_HUMAN reviewed WD repeat-containing protein 17 WDR17 Homo sapiens (Human) 1322 0 0 0 0 0 PF12894;PF00400; Q8JG64 CHOYP_PDIA3.1.1 m.60223 sp PDIA3_CHICK 58.836 464 182 6 16 473 24 484 0 547 PDIA3_CHICK reviewed Protein disulfide-isomerase A3 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Glucose-regulated thiol oxidoreductase 58 kDa protein) PDIA3 ERP57 GRP58 Gallus gallus (Chicken) 505 cell redox homeostasis [GO:0045454]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005634; GO:0005783; GO:0005788; GO:0005925; GO:0006457; GO:0009986; GO:0034976; GO:0042470; GO:0043209; GO:0044822; GO:0045454; GO:0070062; GO:2001238 0 0 0 PF00085; Q8JH47 CHOYP_CDK8.1.1 m.12386 sp CDK8_DANRE 74.009 454 101 4 1 438 1 453 0 697 CDK8_DANRE reviewed Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit cdk8) (Mediator of RNA polymerase II transcription subunit cdk8) cdk8 Danio rerio (Zebrafish) (Brachydanio rerio) 464 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0004693; GO:0005524; GO:0005634; GO:0006351; GO:0006355; GO:0008353 0 0 0 PF00069; Q8JI28 CHOYP_LOC100643173.2.2 m.57316 sp TLL1_XENLA 58.647 902 359 8 159 1055 109 1001 0 1109 TLL1_XENLA reviewed Tolloid-like protein 1 (EC 3.4.24.-) (Metalloprotease xolloid-like) (Xenopus tolloid-like protein 1) (Xlr) tll1 xlr Xenopus laevis (African clawed frog) 1007 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0004222; GO:0005509; GO:0005576; GO:0007275; GO:0008270; GO:0030154 0 0 0 PF01400;PF00431; Q8JI28 CHOYP_LOC658706.1.1 m.21424 sp TLL1_XENLA 51.379 870 406 11 75 934 136 998 0 941 TLL1_XENLA reviewed Tolloid-like protein 1 (EC 3.4.24.-) (Metalloprotease xolloid-like) (Xenopus tolloid-like protein 1) (Xlr) tll1 xlr Xenopus laevis (African clawed frog) 1007 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0004222; GO:0005509; GO:0005576; GO:0007275; GO:0008270; GO:0030154 0 0 0 PF01400;PF00431; Q8JZR6 CHOYP_S4A10.3.4 m.28397 sp S4A8_MOUSE 48 1100 504 22 6 1069 19 1086 0 986 S4A8_MOUSE reviewed Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na+-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) Slc4a8 Kiaa0739 Mus musculus (Mouse) 1089 anion transmembrane transport [GO:0098656]; bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005452; GO:0005886; GO:0005887; GO:0006814; GO:0008509; GO:0015301; GO:0015701; GO:0016020; GO:0032809; GO:0043005; GO:0051453; GO:0098656 0 0 0 PF07565;PF00955; Q8K078 CHOYP_SO4A1.1.1 m.46501 sp SO4A1_MOUSE 45.899 695 345 13 19 697 42 721 0 547 SO4A1_MOUSE reviewed Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Mus musculus (Mouse) 723 organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327] GO:0005887; GO:0008514; GO:0015347; GO:0015349; GO:0015711; GO:0042403; GO:0043252; GO:0070327 0 0 cd06174; PF07648;PF03137; Q8K0C9 CHOYP_GMDS.1.1 m.28602 sp GMDS_MOUSE 74.857 350 88 0 65 414 23 372 0 568 GMDS_MOUSE reviewed "GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)" Gmds Mus musculus (Mouse) 372 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673]; Notch signaling pathway [GO:0007219] GO:0007219; GO:0008446; GO:0019673; GO:0042351; GO:0070062; GO:0070401 PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. 0 0 PF16363; Q8K0E3 CHOYP_SC5A9.1.5 m.4898 sp SC5AB_MOUSE 55.111 450 202 0 10 459 27 476 0 542 SC5AB_MOUSE reviewed Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11) Slc5a11 Kst1 Smit2 Mus musculus (Mouse) 673 apoptotic process [GO:0006915]; carbohydrate transport [GO:0008643]; sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0006915; GO:0008643; GO:0015293 0 0 0 PF00474; Q8K0E3 CHOYP_SC5A9.2.5 m.15452 sp SC5AB_MOUSE 49.36 703 306 9 1 698 16 673 0 666 SC5AB_MOUSE reviewed Sodium/myo-inositol cotransporter 2 (Na(+)/myo-inositol cotransporter 2) (Sodium-dependent glucose cotransporter) (Sodium/glucose cotransporter KST1) (Sodium/myo-inositol transporter 2) (SMIT2) (Solute carrier family 5 member 11) Slc5a11 Kst1 Smit2 Mus musculus (Mouse) 673 apoptotic process [GO:0006915]; carbohydrate transport [GO:0008643]; sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0006915; GO:0008643; GO:0015293 0 0 0 PF00474; Q8K0V4 CHOYP_CNOT3.1.1 m.62322 sp CNOT3_MOUSE 50.376 798 304 17 1 754 1 750 0 656 CNOT3_MOUSE reviewed CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) Cnot3 Not3 Mus musculus (Mouse) 751 "gene silencing by RNA [GO:0031047]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; trophectodermal cell differentiation [GO:0001829]" GO:0000288; GO:0000932; GO:0001829; GO:0005634; GO:0006351; GO:0006355; GO:0017148; GO:0030014; GO:0030015; GO:0031047; GO:0033147; GO:2000036 0 0 0 PF04153;PF04065; Q8K135 CHOYP_LOC100374794.1.1 m.35080 sp K319L_MOUSE 43.546 767 411 9 317 1075 288 1040 0 606 K319L_MOUSE reviewed Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR) Kiaa0319l Aavr Mus musculus (Mouse) 1048 0 GO:0000139; GO:0005886; GO:0016021; GO:0031410; GO:0070062 0 0 0 0 Q8K1R3 CHOYP_PNPT1.1.1 m.9642 sp PNPT1_MOUSE 52.675 729 332 10 23 743 39 762 0 734 PNPT1_MOUSE reviewed "Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)" Pnpt1 Pnpase Mus musculus (Mouse) 783 cellular response to interferon-beta [GO:0035458]; cellular response to oxidative stress [GO:0034599]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA 5'-end processing [GO:0000964]; mitochondrial RNA catabolic process [GO:0000957]; mitochondrion morphogenesis [GO:0070584]; mitotic cell cycle arrest [GO:0071850]; mRNA catabolic process [GO:0006402]; negative regulation of growth [GO:0045926]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; positive regulation of mRNA catabolic process [GO:0061014]; protein homooligomerization [GO:0051260]; protein homotrimerization [GO:0070207]; regulation of cellular respiration [GO:0043457]; regulation of cellular senescence [GO:2000772]; RNA catabolic process [GO:0006401]; RNA import into mitochondrion [GO:0035927]; RNA polyadenylation [GO:0043631]; rRNA import into mitochondrion [GO:0035928] GO:0000175; GO:0000957; GO:0000958; GO:0000962; GO:0000964; GO:0000965; GO:0004654; GO:0005737; GO:0005739; GO:0005758; GO:0006401; GO:0006402; GO:0008266; GO:0016020; GO:0034046; GO:0034599; GO:0035198; GO:0035458; GO:0035927; GO:0035928; GO:0043457; GO:0043631; GO:0044822; GO:0045025; GO:0045926; GO:0051260; GO:0061014; GO:0070207; GO:0070584; GO:0071042; GO:0071850; GO:0097222; GO:2000627; GO:2000772 0 0 0 PF00013;PF03726;PF01138;PF03725;PF00575; Q8K268 CHOYP_LOC100694648.1.1 m.18881 sp ABCF3_MOUSE 57.303 712 294 6 16 721 1 708 0 861 ABCF3_MOUSE reviewed ATP-binding cassette sub-family F member 3 Abcf3 Mus musculus (Mouse) 709 defense response to virus [GO:0051607] GO:0005524; GO:0016020; GO:0016887; GO:0051607 0 0 0 PF00005;PF12848; Q8K2G4 CHOYP_LOC586040.1.1 m.53750 sp BBS7_MOUSE 63.836 730 245 4 2 727 1 715 0 960 BBS7_MOUSE reviewed Bardet-Biedl syndrome 7 protein homolog (BBS2-like protein 1) Bbs7 Bbs2l1 Mus musculus (Mouse) 715 brain development [GO:0007420]; cilium assembly [GO:0042384]; eye development [GO:0001654]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; intracellular transport [GO:0046907]; limb development [GO:0060173]; nonmotile primary cilium assembly [GO:0035058]; palate development [GO:0060021]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; smoothened signaling pathway [GO:0007224] GO:0001103; GO:0001654; GO:0001750; GO:0005634; GO:0005737; GO:0005813; GO:0005930; GO:0006357; GO:0007224; GO:0007420; GO:0007507; GO:0008104; GO:0015031; GO:0016020; GO:0032436; GO:0034464; GO:0035058; GO:0036064; GO:0042384; GO:0045444; GO:0046907; GO:0060021; GO:0060170; GO:0060173 0 0 0 0 Q8K2V6 CHOYP_IPO11.1.1 m.10814 sp IPO11_MOUSE 49.61 770 377 6 4 767 207 971 0 732 IPO11_MOUSE reviewed Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11) Ipo11 Ranbp11 Mus musculus (Mouse) 975 ribosomal protein import into nucleus [GO:0006610]; transcription factor import into nucleus [GO:0042991] GO:0005635; GO:0005829; GO:0006610; GO:0008565; GO:0042991 0 0 0 PF03810; Q8K2Z2 CHOYP_BRAFLDRAFT_117858.2.3 m.48274 sp PRP39_MOUSE 49.298 641 283 14 9 636 51 662 0 585 PRP39_MOUSE reviewed Pre-mRNA-processing factor 39 (PRP39 homolog) Prpf39 Mus musculus (Mouse) 665 mRNA 5'-splice site recognition [GO:0000395] GO:0000243; GO:0000395; GO:0005685; GO:0071004 0 0 0 0 Q8K368 CHOYP_FANCI.1.1 m.6336 sp FANCI_MOUSE 43.445 1312 697 20 8 1297 9 1297 0 1058 FANCI_MOUSE reviewed Fanconi anemia group I protein homolog (Protein FACI) Fanci Mus musculus (Mouse) 1330 DNA repair [GO:0006281]; mitotic G2 DNA damage checkpoint [GO:0007095]; positive regulation of protein ubiquitination [GO:0031398] GO:0005654; GO:0005737; GO:0006281; GO:0007095; GO:0016020; GO:0031398; GO:0043240; GO:0070182 0 0 0 PF14679;PF14680;PF14675;PF14674;PF14676;PF14677;PF14678; Q8K370 CHOYP_LOC100375888.1.1 m.18951 sp ACD10_MOUSE 51.859 1049 482 7 13 1040 13 1059 0 1105 ACD10_MOUSE reviewed Acyl-CoA dehydrogenase family member 10 (ACAD-10) (EC 1.3.99.-) Acad10 Mus musculus (Mouse) 1069 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088] GO:0000062; GO:0003995; GO:0005739; GO:0009055; GO:0016787; GO:0033539; GO:0050660; GO:0052890; GO:0055088 0 0 0 PF00441;PF02770;PF02771;PF01636;PF13419; Q8K3X2 CHOYP_FCL.1.1 m.13504 sp FCL_CRIGR 75 312 78 0 7 318 10 321 0 507 FCL_CRIGR reviewed "GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein)" TSTA3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 321 'de novo' GDP-L-fucose biosynthetic process [GO:0042351] GO:0016853; GO:0042351; GO:0050577; GO:0050662 PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2. 0 cd05239; PF01370; Q8K4K5 CHOYP_LOC100378221.1.1 m.29052 sp L2GL1_RAT 47.374 971 458 19 2 943 4 950 0 872 L2GL1_RAT reviewed Lethal(2) giant larvae protein homolog 1 (LLGL) (Rgl-1) Llgl1 Rgl1 Rattus norvegicus (Rat) 1036 axonogenesis [GO:0007409]; cortical actin cytoskeleton organization [GO:0030866]; establishment of spindle orientation [GO:0051294]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of Notch signaling pathway [GO:0008593]; regulation of protein secretion [GO:0050708] GO:0000137; GO:0005096; GO:0005886; GO:0006887; GO:0006893; GO:0007409; GO:0008593; GO:0017137; GO:0030424; GO:0030864; GO:0030866; GO:0031901; GO:0032588; GO:0032878; GO:0050708; GO:0051294 0 0 0 PF08596;PF08366; Q8K4L0 CHOYP_LOC100375838.1.1 m.39473 sp DDX54_MOUSE 55.204 759 316 11 107 852 79 826 0 790 DDX54_MOUSE reviewed ATP-dependent RNA helicase DDX54 (EC 3.6.4.13) (DEAD box protein 54) Ddx54 Mus musculus (Mouse) 874 "regulation of transcription, DNA-templated [GO:0006355]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; RNA secondary structure unwinding [GO:0010501]; transcription, DNA-templated [GO:0006351]" GO:0003714; GO:0004004; GO:0005102; GO:0005524; GO:0005634; GO:0005730; GO:0006351; GO:0006355; GO:0006396; GO:0010501; GO:0016020; GO:0016070; GO:0030331; GO:0044822 0 0 0 PF08147;PF00270;PF00271; Q8K4P0 CHOYP_LOC100693575.1.1 m.19082 sp WDR33_MOUSE 68.119 505 143 6 55 546 41 540 0 736 WDR33_MOUSE reviewed pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein WDC146) Wdr33 Wdc146 Mus musculus (Mouse) 1330 mRNA cleavage [GO:0006379]; mRNA processing [GO:0006397] GO:0005581; GO:0005634; GO:0005730; GO:0005847; GO:0006379; GO:0006397; GO:0044822 0 0 0 PF00400; Q8K4Q0 CHOYP_RPTOR.1.1 m.38973 sp RPTOR_MOUSE 60.449 1335 455 17 1 1268 1 1329 0 1628 RPTOR_MOUSE reviewed Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) Rptor Raptor Mus musculus (Mouse) 1335 cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to nutrient levels [GO:0031669]; negative regulation of insulin secretion [GO:0046676]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription from RNA polymerase III promoter [GO:0045945]; regulation of cell size [GO:0008361]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] GO:0001030; GO:0001031; GO:0001032; GO:0001156; GO:0001932; GO:0005654; GO:0005737; GO:0005764; GO:0005765; GO:0008361; GO:0016049; GO:0019901; GO:0030295; GO:0030674; GO:0031669; GO:0031929; GO:0031931; GO:0032008; GO:0032403; GO:0043231; GO:0045945; GO:0046676; GO:0071230; GO:0071889; GO:0071902 0 0 0 PF02985;PF14538;PF00400; Q8MI17 CHOYP_AL1A1.1.1 m.24832 sp AL1A1_RABIT 63.58 486 174 2 43 527 13 496 0 658 AL1A1_RABIT reviewed "Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.36) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic)" ALDH1A1 Oryctolagus cuniculus (Rabbit) 496 retinol metabolic process [GO:0042572] GO:0001758; GO:0005737; GO:0042572 PATHWAY: Cofactor metabolism; retinol metabolism. 0 0 PF00171; Q8MIQ9 CHOYP_OCA2.1.1 m.46084 sp P_PIG 59.454 513 200 4 233 740 336 845 0 598 P_PIG reviewed P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog) Oca2 P Sus scrofa (Pig) 845 anion transmembrane transport [GO:0098656] GO:0005215; GO:0016021; GO:0033162; GO:0098656 0 0 0 PF03600; Q8MV48 CHOYP_DWIL_GK25256.1.1 m.7275 sp GALT7_DROME 58.189 519 207 8 99 609 70 586 0 612 GALT7_DROME reviewed N-acetylgalactosaminyltransferase 7 (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase 7) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7) (pp-GaNTase 7) (dGalNAc-T2) GalNAc-T2 pgant7 CG6394 Drosophila melanogaster (Fruit fly) 591 oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486] GO:0000139; GO:0004653; GO:0005795; GO:0006486; GO:0009312; GO:0012505; GO:0016021; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q8N0W3 CHOYP_FUK.1.1 m.17020 sp FUK_HUMAN 44.373 1084 582 10 6 1086 7 1072 0 901 FUK_HUMAN reviewed L-fucose kinase (Fucokinase) (EC 2.7.1.52) FUK Homo sapiens (Human) 1084 0 GO:0005524; GO:0005829; GO:0050201 0 0 0 PF07959;PF08544;PF00288; Q8N0X2 CHOYP_SPAG16.1.1 m.51927 sp SPG16_HUMAN 47.03 623 292 9 10 627 42 631 0 591 SPG16_HUMAN reviewed Sperm-associated antigen 16 protein (Pf20 protein homolog) SPAG16 PF20 Homo sapiens (Human) 631 axoneme assembly [GO:0035082]; cell motility in response to calcium ion [GO:0097231]; cilium assembly [GO:0042384]; cilium movement involved in cell motility [GO:0060294]; microtubule sliding [GO:0051012]; sperm axoneme assembly [GO:0007288] GO:0005634; GO:0005737; GO:0005930; GO:0007288; GO:0031514; GO:0035082; GO:0042384; GO:0051012; GO:0060294; GO:0097231; GO:1990716 0 0 0 PF00400; Q8N157 CHOYP_LOC100710392.1.2 m.5180 sp AHI1_HUMAN 39.976 848 423 14 415 1254 340 1109 0 662 AHI1_HUMAN reviewed Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) AHI1 Homo sapiens (Human) 1196 cellular protein localization [GO:0034613]; central nervous system development [GO:0007417]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; cloaca development [GO:0035844]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of apoptotic process [GO:0043066]; otic vesicle development [GO:0071599]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of polarized epithelial cell differentiation [GO:0030862]; positive regulation of receptor internalization [GO:0002092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pronephric duct morphogenesis [GO:0039023]; pronephric nephron tubule morphogenesis [GO:0039008]; regulation of behavior [GO:0050795]; retina layer formation [GO:0010842]; specification of axis polarity [GO:0065001]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vesicle-mediated transport [GO:0016192] GO:0001738; GO:0001947; GO:0002092; GO:0005813; GO:0005814; GO:0005829; GO:0005911; GO:0005912; GO:0005929; GO:0007169; GO:0007417; GO:0010842; GO:0016192; GO:0030862; GO:0030902; GO:0031513; GO:0034613; GO:0035844; GO:0035845; GO:0036038; GO:0036064; GO:0039008; GO:0039023; GO:0042384; GO:0042802; GO:0043066; GO:0045944; GO:0050795; GO:0060271; GO:0065001; GO:0070121; GO:0070986; GO:0071599; GO:0072372 0 0 0 PF00018;PF00400; Q8N157 CHOYP_LOC100710392.2.2 m.14001 sp AHI1_HUMAN 40.094 848 422 16 617 1456 340 1109 0 664 AHI1_HUMAN reviewed Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) AHI1 Homo sapiens (Human) 1196 cellular protein localization [GO:0034613]; central nervous system development [GO:0007417]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; cloaca development [GO:0035844]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of apoptotic process [GO:0043066]; otic vesicle development [GO:0071599]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of polarized epithelial cell differentiation [GO:0030862]; positive regulation of receptor internalization [GO:0002092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pronephric duct morphogenesis [GO:0039023]; pronephric nephron tubule morphogenesis [GO:0039008]; regulation of behavior [GO:0050795]; retina layer formation [GO:0010842]; specification of axis polarity [GO:0065001]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vesicle-mediated transport [GO:0016192] GO:0001738; GO:0001947; GO:0002092; GO:0005813; GO:0005814; GO:0005829; GO:0005911; GO:0005912; GO:0005929; GO:0007169; GO:0007417; GO:0010842; GO:0016192; GO:0030862; GO:0030902; GO:0031513; GO:0034613; GO:0035844; GO:0035845; GO:0036038; GO:0036064; GO:0039008; GO:0039023; GO:0042384; GO:0042802; GO:0043066; GO:0045944; GO:0050795; GO:0060271; GO:0065001; GO:0070121; GO:0070986; GO:0071599; GO:0072372 0 0 0 PF00018;PF00400; Q8N1B4 CHOYP_BRAFLDRAFT_97676.1.1 m.62102 sp VPS52_HUMAN 61.816 694 254 3 12 704 40 723 0 931 VPS52_HUMAN reviewed Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) VPS52 SACM2L Homo sapiens (Human) 723 ectodermal cell differentiation [GO:0010668]; embryonic ectodermal digestive tract development [GO:0048611]; endocytic recycling [GO:0032456]; lysosomal transport [GO:0007041]; protein transport [GO:0015031] GO:0000938; GO:0005794; GO:0007041; GO:0010008; GO:0010668; GO:0015031; GO:0016020; GO:0019905; GO:0032456; GO:0032588; GO:0048471; GO:0048611; GO:0055037; GO:1990745 0 0 0 PF04129; Q8N1E6 CHOYP_FXL14.1.1 m.30239 sp FXL14_HUMAN 68.895 389 121 0 29 417 4 392 0 546 FXL14_HUMAN reviewed F-box/LRR-repeat protein 14 (F-box and leucine-rich repeat protein 14) FBXL14 FBL14 Homo sapiens (Human) 418 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005654; GO:0005737; GO:0005794; GO:0042787 0 0 0 PF12937;PF13516; Q8N5C6 CHOYP_BRAFLDRAFT_123927.1.1 m.18473 sp SRBD1_HUMAN 41.096 803 427 11 24 802 211 991 0 616 SRBD1_HUMAN reviewed S1 RNA-binding domain-containing protein 1 SRBD1 Homo sapiens (Human) 995 nucleobase-containing compound metabolic process [GO:0006139] GO:0003723; GO:0006139 0 0 0 PF00575;PF09371;PF16921; Q8N5D0 CHOYP_BRAFLDRAFT_74529.1.1 m.14833 sp WDTC1_HUMAN 49.229 713 313 9 8 716 10 677 0 681 WDTC1_HUMAN reviewed WD and tetratricopeptide repeats protein 1 WDTC1 KIAA1037 Homo sapiens (Human) 677 cellular chemical homeostasis [GO:0055082]; cellular response to insulin stimulus [GO:0032869]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of cell size [GO:0008361] GO:0000122; GO:0001701; GO:0004857; GO:0005634; GO:0005829; GO:0006006; GO:0008361; GO:0016567; GO:0032869; GO:0035264; GO:0045717; GO:0055082 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q8N5T2 CHOYP_TBC19.1.1 m.45306 sp TBC19_HUMAN 60.952 525 192 1 11 535 12 523 0 644 TBC19_HUMAN reviewed TBC1 domain family member 19 TBC1D19 Homo sapiens (Human) 526 0 GO:0005096 0 0 0 PF00566; Q8N653 CHOYP_LOC100747020.1.1 m.783 sp LZTR1_HUMAN 59.125 800 247 7 14 743 36 825 0 952 LZTR1_HUMAN reviewed Leucine-zipper-like transcriptional regulator 1 (LZTR-1) LZTR1 TCFL2 Homo sapiens (Human) 840 anatomical structure morphogenesis [GO:0009653] GO:0003700; GO:0005794; GO:0009653 0 0 0 PF00651;PF01344;PF07646; Q8N7N5 CHOYP_BRAFLDRAFT_65670.1.1 m.26875 sp DCAF8_MOUSE 53.55 493 208 7 234 714 60 543 0 537 DCAF8_MOUSE reviewed DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) Dcaf8 D1Ucla4 H326 Wdr42a Mus musculus (Mouse) 591 protein ubiquitination [GO:0016567] GO:0005634; GO:0005737; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q8N7N5 CHOYP_LIPS.1.2 m.16071 sp DCAF8_MOUSE 53.55 493 208 7 234 714 60 543 0 537 DCAF8_MOUSE reviewed DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) Dcaf8 D1Ucla4 H326 Wdr42a Mus musculus (Mouse) 591 protein ubiquitination [GO:0016567] GO:0005634; GO:0005737; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q8N7X0 CHOYP_contig_049136 m.58269 sp ADGB_HUMAN 37.793 1577 741 35 65 1573 35 1439 0 934 ADGB_HUMAN reviewed Androglobin (Calpain-7-like protein) ADGB C6orf103 CAPN7L Homo sapiens (Human) 1667 proteolysis [GO:0006508] GO:0004198; GO:0005737; GO:0006508; GO:0019825; GO:0020037 0 0 0 PF00648; Q8N8E3 CHOYP_CE112.1.2 m.11508 sp CE112_HUMAN 44.433 961 479 10 3 924 4 948 0 739 CE112_HUMAN reviewed Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) CEP112 CCDC46 Homo sapiens (Human) 955 receptor localization to synapse [GO:0097120] GO:0005737; GO:0005813; GO:0005886; GO:0060077; GO:0097120 0 0 0 PF14846; Q8N8E3 CHOYP_CE112.2.2 m.12076 sp CE112_HUMAN 43.943 974 506 10 3 965 4 948 0 732 CE112_HUMAN reviewed Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46) CEP112 CCDC46 Homo sapiens (Human) 955 receptor localization to synapse [GO:0097120] GO:0005737; GO:0005813; GO:0005886; GO:0060077; GO:0097120 0 0 0 PF14846; Q8N960 CHOYP_CE120.1.2 m.19214 sp CE120_HUMAN 49.903 1032 455 14 1 1018 1 984 0 973 CE120_HUMAN reviewed Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) CEP120 CCDC100 Homo sapiens (Human) 986 astral microtubule organization [GO:0030953]; centrosome organization [GO:0051297]; cerebral cortex development [GO:0021987]; interkinetic nuclear migration [GO:0022027]; neurogenesis [GO:0022008]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of cilium assembly [GO:0045724]; regulation of protein localization [GO:0032880] GO:0005813; GO:0005814; GO:0010825; GO:0021987; GO:0022008; GO:0022027; GO:0030953; GO:0032880; GO:0045724; GO:0051297 0 0 0 PF00168;PF12416; Q8NB25 CHOYP_LOC590343.1.1 m.17192 sp F184A_HUMAN 36.667 1110 673 10 18 1106 1 1101 0 593 F184A_HUMAN reviewed Protein FAM184A FAM184A C6orf60 Homo sapiens (Human) 1140 0 GO:0005615 0 0 0 0 Q8NB78 CHOYP_KDM1B.1.1 m.15843 sp KDM1B_HUMAN 45.477 807 401 9 6 783 23 819 0 717 KDM1B_HUMAN reviewed Lysine-specific histone demethylase 1B (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 2) KDM1B AOF1 C6orf193 LSD2 Homo sapiens (Human) 822 "DNA methylation involved in gamete generation [GO:0043046]; histone H3-K4 demethylation [GO:0034720]; multicellular organism development [GO:0007275]; regulation of DNA methylation [GO:0044030]; regulation of gene expression by genetic imprinting [GO:0006349]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006349; GO:0006351; GO:0006355; GO:0007275; GO:0008270; GO:0032452; GO:0034648; GO:0034649; GO:0034720; GO:0043046; GO:0044030; GO:0050660 0 0 0 PF01593;PF04433;PF07496; Q8NB90 CHOYP_LOC101072049.1.1 m.24465 sp SPAT5_HUMAN 57.118 576 238 2 149 716 319 893 0 695 SPAT5_HUMAN reviewed Spermatogenesis-associated protein 5 (ATPase family protein 2 homolog) (Spermatogenesis-associated factor protein) SPATA5 AFG2 SPAF Homo sapiens (Human) 893 brain development [GO:0007420]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0005524; GO:0005737; GO:0005739; GO:0007283; GO:0007420; GO:0030154 0 0 0 PF00004; Q8NBP0 CHOYP_TTC13.1.1 m.9179 sp TTC13_HUMAN 38.03 731 442 10 139 861 125 852 0 550 TTC13_HUMAN reviewed Tetratricopeptide repeat protein 13 (TPR repeat protein 13) TTC13 PSEC0076 Homo sapiens (Human) 860 0 0 0 0 0 PF00515;PF13181; Q8NBS3 CHOYP_ISCW_ISCW009278.1.1 m.28146 sp S4A11_HUMAN 48.885 628 303 7 1 623 274 888 0 573 S4A11_HUMAN reviewed Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) 891 bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular cation homeostasis [GO:0030003]; fluid transport [GO:0042044]; proton transport [GO:0015992]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005272; GO:0005452; GO:0005887; GO:0006814; GO:0015106; GO:0015252; GO:0015293; GO:0015301; GO:0015701; GO:0015992; GO:0016323; GO:0030003; GO:0042044; GO:0046713; GO:0046715; GO:0046983; GO:0051453 0 0 0 PF00955; Q8NBS3 CHOYP_LOC579418.1.2 m.45812 sp S4A11_HUMAN 46.964 741 367 10 118 846 107 833 0 652 S4A11_HUMAN reviewed Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) 891 bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular cation homeostasis [GO:0030003]; fluid transport [GO:0042044]; proton transport [GO:0015992]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005272; GO:0005452; GO:0005887; GO:0006814; GO:0015106; GO:0015252; GO:0015293; GO:0015301; GO:0015701; GO:0015992; GO:0016323; GO:0030003; GO:0042044; GO:0046713; GO:0046715; GO:0046983; GO:0051453 0 0 0 PF00955; Q8NBS3 CHOYP_LOC579418.2.2 m.54218 sp S4A11_HUMAN 45.797 797 396 13 128 892 96 888 0 649 S4A11_HUMAN reviewed Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) 891 bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular cation homeostasis [GO:0030003]; fluid transport [GO:0042044]; proton transport [GO:0015992]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005272; GO:0005452; GO:0005887; GO:0006814; GO:0015106; GO:0015252; GO:0015293; GO:0015301; GO:0015701; GO:0015992; GO:0016323; GO:0030003; GO:0042044; GO:0046713; GO:0046715; GO:0046983; GO:0051453 0 0 0 PF00955; Q8NBS3 CHOYP_LOC579418.2.2 m.54219 sp S4A11_HUMAN 45.797 797 396 13 128 892 96 888 0 649 S4A11_HUMAN reviewed Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) 891 bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular cation homeostasis [GO:0030003]; fluid transport [GO:0042044]; proton transport [GO:0015992]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005272; GO:0005452; GO:0005887; GO:0006814; GO:0015106; GO:0015252; GO:0015293; GO:0015301; GO:0015701; GO:0015992; GO:0016323; GO:0030003; GO:0042044; GO:0046713; GO:0046715; GO:0046983; GO:0051453 0 0 0 PF00955; Q8NCN5 CHOYP_LOC100642881.1.1 m.14183 sp PDPR_HUMAN 46.512 860 441 12 29 883 17 862 0 746 PDPR_HUMAN reviewed "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)" PDPR KIAA1990 Homo sapiens (Human) 879 regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510] GO:0004741; GO:0005737; GO:0005759; GO:0010510; GO:0016491 0 0 0 PF01266;PF16350;PF01571;PF08669; Q8NDA8 CHOYP_MROH1.1.1 m.24366 sp MROH1_HUMAN 36.659 1664 1007 15 14 1656 2 1639 0 1130 MROH1_HUMAN reviewed Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) 1641 0 0 0 0 0 PF02985; Q8NDG6 CHOYP_LOC100891933.1.1 m.14752 sp TDRD9_HUMAN 43.444 1266 678 13 143 1387 132 1380 0 1028 TDRD9_HUMAN reviewed Putative ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9) TDRD9 C14orf75 Homo sapiens (Human) 1382 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283] GO:0004004; GO:0005524; GO:0005634; GO:0006396; GO:0007140; GO:0007275; GO:0007283; GO:0009566; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:0043186; GO:0044822; GO:0071547 0 0 0 PF00270;PF04408;PF00271;PF00567; Q8NDM7 CHOYP_LOC100377024.1.2 m.45413 sp CFA43_HUMAN 33.994 1715 1051 23 5 1707 17 1662 0 930 CFA43_HUMAN reviewed Cilia- and flagella-associated protein 43 (WD repeat-containing protein 96) CFAP43 C10orf79 WDR96 Homo sapiens (Human) 1665 0 GO:0042995 0 0 0 0 Q8NDM7 CHOYP_LOC100377024.2.2 m.63302 sp CFA43_HUMAN 34.291 1741 1035 24 5 1728 17 1665 0 937 CFA43_HUMAN reviewed Cilia- and flagella-associated protein 43 (WD repeat-containing protein 96) CFAP43 C10orf79 WDR96 Homo sapiens (Human) 1665 0 GO:0042995 0 0 0 0 Q8NDN9 CHOYP_BRAFLDRAFT_119547.1.1 m.61230 sp RCBT1_HUMAN 60.377 530 210 0 1 530 1 530 0 709 RCBT1_HUMAN reviewed RCC1 and BTB domain-containing protein 1 (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein) (Regulator of chromosome condensation and BTB domain-containing protein 1) RCBTB1 CLLD7 E4.5 Homo sapiens (Human) 531 "cell cycle [GO:0007049]; covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007049; GO:0016569 0 0 0 PF00651;PF00415; Q8NE09 CHOYP_RGS22.1.2 m.46140 sp RGS22_HUMAN 37.238 905 478 14 502 1396 404 1228 0 577 RGS22_HUMAN reviewed Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) 1264 negative regulation of signal transduction [GO:0009968] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0009968 0 0 0 PF00615; Q8NEV4 CHOYP_LOC100689818.1.1 m.3313 sp MYO3A_HUMAN 51.797 1141 501 12 10 1131 7 1117 0 1170 MYO3A_HUMAN reviewed Myosin-IIIa (EC 2.7.11.1) MYO3A Homo sapiens (Human) 1616 protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0000146; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0007601; GO:0007605; GO:0016459; GO:0030175; GO:0030898; GO:0031941; GO:0043531; GO:0046777; GO:0050896; GO:0060002 0 0 0 PF00612;PF00063;PF00069; Q8NEZ4 CHOYP_MLL2.1.1 m.56087 sp KMT2C_HUMAN 44.929 848 384 16 1462 2242 4080 4911 0 758 KMT2C_HUMAN reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) 4911 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0008270; GO:0016746; GO:0018024; GO:0035097; GO:0042800; GO:0044666; GO:0044822 0 0 0 PF05965;PF05964;PF00628;PF00856; Q8NF91 CHOYP_LOC100876515.1.2 m.37063 sp SYNE1_HUMAN 23.259 5039 3545 86 22 4890 21 4907 0 1120 SYNE1_HUMAN reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) 8797 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0006997; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q8NF91 CHOYP_LOC100876515.2.2 m.54514 sp SYNE1_HUMAN 23.302 5021 3550 84 51 4901 18 4907 0 1129 SYNE1_HUMAN reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) 8797 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0006997; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q8NFA0 CHOYP_UBP32.1.1 m.56373 sp UBP32_HUMAN 50.98 1377 602 16 1 1366 1 1315 0 1409 UBP32_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) USP32 USP10 Homo sapiens (Human) 1604 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005509; GO:0005737; GO:0005794; GO:0006511; GO:0016020; GO:0016579 0 0 0 PF06337;PF13202;PF14836;PF00443; Q8NFJ9 CHOYP_LOC100369017.1.1 m.27033 sp BBS1_HUMAN 54.593 577 259 3 26 601 19 593 0 675 BBS1_HUMAN reviewed Bardet-Biedl syndrome 1 protein (BBS2-like protein 2) BBS1 BBS2L2 Homo sapiens (Human) 593 cilium assembly [GO:0042384]; Golgi to plasma membrane protein transport [GO:0043001]; nonmotile primary cilium assembly [GO:0035058]; photoreceptor cell maintenance [GO:0045494]; protein localization to cilium [GO:0061512]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; visual perception [GO:0007601] GO:0001103; GO:0001895; GO:0005113; GO:0005119; GO:0005813; GO:0005829; GO:0005930; GO:0007601; GO:0034464; GO:0035058; GO:0036064; GO:0042384; GO:0043001; GO:0045494; GO:0050896; GO:0060170; GO:0061512 0 0 0 PF14779; Q8NHH9 CHOYP_LOC100374960.1.1 m.25267 sp ATLA2_HUMAN 61.84 511 187 2 24 534 60 562 0 669 ATLA2_HUMAN reviewed Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) ATL2 ARL6IP2 Homo sapiens (Human) 583 endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0007029; GO:0007030; GO:0016020; GO:0016021; GO:0042802; GO:0051260 0 0 0 PF02263;PF02841; Q8NHU2 CHOYP_LOC100378255.1.1 m.63185 sp CFA61_HUMAN 49.828 1164 551 6 1 1162 105 1237 0 1157 CFA61_HUMAN reviewed Cilia- and flagella-associated protein 61 CFAP61 C20orf26 Homo sapiens (Human) 1237 0 GO:0016491 0 0 0 PF16092; Q8NI36 CHOYP_BRAFLDRAFT_276592.1.1 m.8046 sp WDR36_HUMAN 51.627 891 419 8 3 887 65 949 0 916 WDR36_HUMAN reviewed WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP) WDR36 Homo sapiens (Human) 951 regulation of axon extension [GO:0030516]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; rRNA processing [GO:0006364]; visual perception [GO:0007601] GO:0001895; GO:0005654; GO:0005730; GO:0006364; GO:0007601; GO:0030516; GO:0032040; GO:0044822; GO:0050896 0 0 0 PF12894;PF04192;PF00400; Q8QFV0 CHOYP_PHUM_PHUM562900.1.1 m.43674 sp KCNT1_CHICK 38.06 1206 604 25 17 1143 52 1193 0 785 KCNT1_CHICK reviewed Potassium channel subfamily T member 1 (Sequence like a calcium-activated potassium channel subunit) KCNT1 SLACK Gallus gallus (Chicken) 1201 0 GO:0005249; GO:0008076; GO:0015269 0 0 0 PF03493;PF07885; Q8QG61 CHOYP_XL64PHR.1.1 m.24123 sp CRY1_CHICK 58.635 498 200 2 1 492 1 498 0 636 CRY1_CHICK reviewed Cryptochrome-1 CRY1 Gallus gallus (Chicken) 621 "protein-chromophore linkage [GO:0018298]; regulation of transcription, DNA-templated [GO:0006355]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0009881; GO:0018298; GO:0042622; GO:0048511; GO:0097381 0 0 0 PF00875;PF03441; Q8QGX4 CHOYP_PRKDC.1.1 m.47256 sp PRKDC_CHICK 39.849 2645 1461 42 19 2596 1553 4134 0 1956 PRKDC_CHICK reviewed DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC XRCC7 Gallus gallus (Chicken) 4134 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431] GO:0000724; GO:0003677; GO:0004677; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006281; GO:0006303; GO:0016301; GO:0070419; GO:0072431 0 0 0 PF02259;PF02260;PF08163;PF00454; Q8QGX4 CHOYP_TRIADDRAFT_20924.1.1 m.64095 sp PRKDC_CHICK 34.765 1234 760 19 4 1215 1254 2464 0 761 PRKDC_CHICK reviewed DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC XRCC7 Gallus gallus (Chicken) 4134 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431] GO:0000724; GO:0003677; GO:0004677; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006281; GO:0006303; GO:0016301; GO:0070419; GO:0072431 0 0 0 PF02259;PF02260;PF08163;PF00454; Q8QZR1 CHOYP_BRAFLDRAFT_275580.2.2 m.40924 sp ATTY_MOUSE 58.354 413 171 1 1 412 30 442 0 521 ATTY_MOUSE reviewed Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) Tat Mus musculus (Mouse) 454 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; L-phenylalanine catabolic process [GO:0006559]; response to glucocorticoid [GO:0051384]; response to mercury ion [GO:0046689]; response to oxidative stress [GO:0006979]; tyrosine catabolic process [GO:0006572] GO:0004838; GO:0005739; GO:0006103; GO:0006536; GO:0006559; GO:0006572; GO:0006979; GO:0009058; GO:0016597; GO:0030170; GO:0046689; GO:0051384; GO:0080130 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6. 0 0 PF00155;PF07706; Q8R050 CHOYP_ERF3A.1.1 m.57282 sp ERF3A_MOUSE 59.643 617 169 10 9 553 23 631 0 716 ERF3A_MOUSE reviewed Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog) Gspt1 Erf3a Mus musculus (Mouse) 636 "cytoplasmic translational termination [GO:0002184]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]" GO:0000184; GO:0002184; GO:0003747; GO:0003924; GO:0005525; GO:0005829; GO:0006479; GO:0018444; GO:0044822 0 0 0 PF03144;PF03143;PF07145; Q8R0G9 CHOYP_LOC100374754.1.1 m.32299 sp NU133_MOUSE 37.094 1170 671 30 24 1152 7 1152 0 706 NU133_MOUSE reviewed Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133) Nup133 Mus musculus (Mouse) 1155 "chromatin organization [GO:0006325]; mRNA export from nucleus [GO:0006406]; neural tube development [GO:0021915]; neurogenesis [GO:0022008]; nuclear pore distribution [GO:0031081]; nuclear pore organization [GO:0006999]; paraxial mesoderm development [GO:0048339]; protein import into nucleus [GO:0006606]; regulation of transcription, DNA-templated [GO:0006355]; RNA export from nucleus [GO:0006405]; somite development [GO:0061053]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]" GO:0000940; GO:0000972; GO:0005487; GO:0005643; GO:0006325; GO:0006355; GO:0006405; GO:0006406; GO:0006606; GO:0006999; GO:0016020; GO:0017056; GO:0021915; GO:0022008; GO:0031080; GO:0031081; GO:0031965; GO:0048339; GO:0061053 0 0 0 PF03177; Q8R146 CHOYP_LOC100027962.1.1 m.48278 sp APEH_MOUSE 41.748 721 397 9 8 708 13 730 0 565 APEH_MOUSE reviewed Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) Apeh Mus musculus (Mouse) 732 beta-amyloid metabolic process [GO:0050435]; proteolysis [GO:0006508] GO:0004252; GO:0005737; GO:0006508; GO:0008242; GO:0031965; GO:0044822; GO:0050435; GO:0070062 0 0 0 PF00326; Q8R151 CHOYP_BRAFLDRAFT_234820.1.1 m.63187 sp ZNFX1_MOUSE 40.683 1846 976 36 36 1841 136 1902 0 1332 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_BRAFLDRAFT_234854.1.2 m.51029 sp ZNFX1_MOUSE 41.544 816 402 17 1 795 431 1192 0 578 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_LOC100163831.1.1 m.53609 sp ZNFX1_MOUSE 33.75 1440 775 43 100 1438 189 1550 0 671 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_LOC100371500.3.7 m.33283 sp ZNFX1_MOUSE 35.004 1277 726 28 105 1319 232 1466 0 705 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_LOC100371500.5.7 m.54508 sp ZNFX1_MOUSE 32.391 1556 843 43 4 1477 118 1546 0 693 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_LOC100371500.7.7 m.58612 sp ZNFX1_MOUSE 33.381 1408 797 34 108 1430 237 1588 0 674 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_LOC100373100.2.4 m.51030 sp ZNFX1_MOUSE 46.018 904 464 13 1 891 1013 1905 0 826 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_LOC100536767.2.2 m.56166 sp ZNFX1_MOUSE 31.413 1840 986 67 100 1828 189 1863 0 730 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_LOC594076.1.1 m.46356 sp ZNFX1_MOUSE 36.195 1188 650 27 30 1154 324 1466 0 685 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_ZNFX1.10.12 m.61360 sp ZNFX1_MOUSE 34.972 1790 976 46 256 1952 203 1897 0 954 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R151 CHOYP_ZNFX1.2.12 m.5017 sp ZNFX1_MOUSE 38.126 1558 848 29 2 1504 406 1902 0 1030 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R1F6 CHOYP_BRAFLDRAFT_200209.1.1 m.2016 sp HID1_MOUSE 71.762 386 100 2 1 379 405 788 0 559 HID1_MOUSE reviewed Protein HID1 (HID1 domain-containing protein) (Protein hid-1 homolog) Hid1 Mus musculus (Mouse) 788 intracellular protein transport [GO:0006886]; response to brefeldin A [GO:0031001] GO:0000138; GO:0005737; GO:0005794; GO:0005797; GO:0005881; GO:0006886; GO:0016020; GO:0031001; GO:0070062; GO:0090498 0 0 0 0 Q8R317 CHOYP_UBQL4.1.1 m.37426 sp UBQL1_MOUSE 51.171 598 216 12 7 573 25 577 0 527 UBQL1_MOUSE reviewed Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) Ubqln1 Plic1 Mus musculus (Mouse) 582 aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to hypoxia [GO:0071456]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; macroautophagy [GO:0016236]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of store-operated calcium channel activity [GO:1901340]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of protein ubiquitination [GO:0031398]; regulation of autophagosome assembly [GO:2000785]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976] GO:0000045; GO:0000502; GO:0005102; GO:0005654; GO:0005737; GO:0005776; GO:0005783; GO:0005886; GO:0016235; GO:0016236; GO:0019215; GO:0019900; GO:0030433; GO:0031396; GO:0031398; GO:0031410; GO:0031593; GO:0034140; GO:0034976; GO:0035973; GO:0042802; GO:0043234; GO:0048471; GO:0071456; GO:0097352; GO:1901097; GO:1901340; GO:1902175; GO:1903071; GO:2000785 0 0 0 PF00627;PF00240; Q8R323 CHOYP_RFC3.1.1 m.48357 sp RFC3_MOUSE 76.068 351 83 1 24 373 1 351 0 565 RFC3_MOUSE reviewed Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38) Rfc3 Mus musculus (Mouse) 356 DNA-dependent DNA replication [GO:0006261]; DNA replication [GO:0006260]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; response to organophosphorus [GO:0046683] GO:0003677; GO:0005634; GO:0005663; GO:0006260; GO:0006261; GO:0016887; GO:0031390; GO:0046683; GO:1900264 0 0 0 0 Q8R3L2 CHOYP_TCF25.1.1 m.28509 sp TCF25_MOUSE 44.687 687 332 11 1 650 1 676 0 553 TCF25_MOUSE reviewed Transcription factor 25 (TCF-25) (Nuclear localized protein 1) Tcf25 D8Ertd325e Nulp1 Mus musculus (Mouse) 676 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003700; GO:0005634; GO:0006351 0 0 0 PF04910; Q8R3N6 CHOYP_THOC1.1.1 m.62740 sp THOC1_MOUSE 47.976 667 316 8 17 673 8 653 0 602 THOC1_MOUSE reviewed THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) Thoc1 Hpr1 Mus musculus (Mouse) 657 "apoptotic process [GO:0006915]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; negative regulation of DNA damage checkpoint [GO:2000002]; negative regulation of isotype switching to IgA isotypes [GO:0048297]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of DNA recombination [GO:0000018]; regulation of DNA-templated transcription, elongation [GO:0032784]; replication fork processing [GO:0031297]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]; viral mRNA export from host cell nucleus [GO:0046784]" GO:0000018; GO:0000346; GO:0000347; GO:0000445; GO:0000781; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006397; GO:0006406; GO:0006915; GO:0007165; GO:0008380; GO:0016363; GO:0016607; GO:0031297; GO:0032784; GO:0032786; GO:0045171; GO:0046784; GO:0048297; GO:2000002 0 0 0 PF00531;PF11957; Q8R4G6 CHOYP_MGT5A.1.1 m.54555 sp MGT5A_MOUSE 48.172 766 363 10 3 764 5 740 0 731 MGT5A_MOUSE reviewed "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V)" Mgat5 Mus musculus (Mouse) 740 protein N-linked glycosylation [GO:0006487] GO:0000139; GO:0005794; GO:0006487; GO:0008375; GO:0016021; GO:0016757; GO:0030144; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF15027; Q8R4U0 CHOYP_STAB2.1.1 m.64132 sp STAB2_MOUSE 32.131 1553 924 46 32 1521 34 1519 0 736 STAB2_MOUSE reviewed "Stabilin-2 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) [Cleaved into: Short form stabilin-2]" Stab2 Feel2 Hare Mus musculus (Mouse) 2559 cell adhesion [GO:0007155]; defense response to bacterium [GO:0042742]; endocytosis [GO:0006897]; regulation of blood coagulation [GO:0030193]; regulation of gene expression [GO:0010468] GO:0005041; GO:0005044; GO:0005509; GO:0005540; GO:0005737; GO:0005887; GO:0006897; GO:0007155; GO:0009897; GO:0010468; GO:0030169; GO:0030193; GO:0042742 0 0 0 PF12947;PF02469;PF00193; Q8R500 CHOYP_PHUM_PHUM579670.1.1 m.63016 sp MFN2_RAT 49.795 731 345 4 38 748 27 755 0 755 MFN2_RAT reviewed Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) Mfn2 Fzo1a Rattus norvegicus (Rat) 757 apoptotic process [GO:0006915]; autophagy [GO:0006914]; mitochondrial fusion [GO:0008053]; mitochondrial membrane organization [GO:0007006]; negative regulation of cell proliferation [GO:0008285]; negative regulation of smooth muscle cell proliferation [GO:0048662]; protein targeting to mitochondrion [GO:0006626]; response to unfolded protein [GO:0006986] GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005829; GO:0006626; GO:0006914; GO:0006915; GO:0006986; GO:0007006; GO:0008053; GO:0008285; GO:0016021; GO:0031306; GO:0048662; GO:0051020 0 0 0 PF00350;PF04799; Q8T6A5 CHOYP_LOC100366892.3.3 m.66686 sp TBA1_APLCA 97.761 268 6 0 1 268 154 421 0 553 TBA1_APLCA reviewed Tubulin alpha-1 chain 0 Aplysia californica (California sea hare) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q8TAD4 CHOYP_ZNT5.1.1 m.7307 sp ZNT5_HUMAN 54.733 729 323 3 19 741 26 753 0 774 ZNT5_HUMAN reviewed Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) (ZnT-like transporter 1) (hZTL1) SLC30A5 ZNT5 ZNTL1 ZTL1 UNQ863/PRO1879 Homo sapiens (Human) 765 cellular zinc ion homeostasis [GO:0006882]; cobalt ion transport [GO:0006824]; regulation of proton transport [GO:0010155]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; zinc II ion transport [GO:0006829] GO:0005385; GO:0005634; GO:0005730; GO:0005794; GO:0005887; GO:0006824; GO:0006829; GO:0006882; GO:0008270; GO:0010043; GO:0010155; GO:0016020; GO:0016324; GO:0030141; GO:0030667; GO:0061088 0 0 0 PF01545; Q8TAM2 CHOYP_TTC8.1.1 m.35457 sp TTC8_HUMAN 65.922 537 145 4 1 499 5 541 0 767 TTC8_HUMAN reviewed Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein) TTC8 BBS8 Homo sapiens (Human) 541 cilium assembly [GO:0042384]; establishment of anatomical structure orientation [GO:0048560]; protein transport [GO:0015031]; sensory processing [GO:0050893] GO:0001103; GO:0005813; GO:0005829; GO:0005929; GO:0015031; GO:0034464; GO:0036064; GO:0042384; GO:0048560; GO:0050893; GO:0060170 0 0 0 PF13176; Q8TAQ2 CHOYP_SMRC2.2.2 m.49912 sp SMRC2_HUMAN 60.685 964 343 15 18 964 3 947 0 1086 SMRC2_HUMAN reviewed SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) SMARCC2 BAF170 Homo sapiens (Human) 1214 "ATP-dependent chromatin remodeling [GO:0043044]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome disassembly [GO:0006337]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment [GO:0021882]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0003677; GO:0003682; GO:0003713; GO:0005654; GO:0006337; GO:0006338; GO:0006351; GO:0006357; GO:0016514; GO:0016569; GO:0021882; GO:0043044; GO:0043234; GO:0045892; GO:0045893; GO:0071564; GO:0071565 0 0 0 PF00249;PF04433;PF16495;PF16496;PF16498; Q8TAQ2 CHOYP_TONSL.1.1 m.18360 sp SMRC2_HUMAN 61.892 761 270 11 1 753 1 749 0 957 SMRC2_HUMAN reviewed SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) SMARCC2 BAF170 Homo sapiens (Human) 1214 "ATP-dependent chromatin remodeling [GO:0043044]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome disassembly [GO:0006337]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment [GO:0021882]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0003677; GO:0003682; GO:0003713; GO:0005654; GO:0006337; GO:0006338; GO:0006351; GO:0006357; GO:0016514; GO:0016569; GO:0021882; GO:0043044; GO:0043234; GO:0045892; GO:0045893; GO:0071564; GO:0071565 0 0 0 PF00249;PF04433;PF16495;PF16496;PF16498; Q8TB22 CHOYP_SPT20.1.1 m.35908 sp SPT20_HUMAN 49.064 748 368 8 40 778 41 784 0 748 SPT20_HUMAN reviewed Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411) SPATA20 Homo sapiens (Human) 786 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0003824; GO:0005576; GO:0007275; GO:0007283; GO:0030154 0 0 cd02955; PF03190; Q8TBG4 CHOYP_LOC100879339.1.1 m.20204 sp AT2L1_HUMAN 60.227 440 166 4 416 853 7 439 0 553 AT2L1_HUMAN reviewed Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1) ETNPPL AGXT2L1 Homo sapiens (Human) 499 phosphatidylethanolamine biosynthetic process [GO:0006646] GO:0005759; GO:0006646; GO:0008483; GO:0030170; GO:0042802; GO:0050459 0 0 cd00610; PF00202; Q8TBP0 CHOYP_LOC100374096.1.1 m.8052 sp TBC16_HUMAN 60.917 458 177 2 493 948 287 744 0 601 TBC16_HUMAN reviewed TBC1 domain family member 16 TBC1D16 Homo sapiens (Human) 767 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of receptor recycling [GO:0001919]; regulation of vesicle fusion [GO:0031338] GO:0001919; GO:0005096; GO:0005769; GO:0005829; GO:0006886; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF00566; Q8TBY9 CHOYP_LOC100377751.1.1 m.26359 sp WDR66_HUMAN 47.603 897 462 6 182 1072 249 1143 0 917 WDR66_HUMAN reviewed WD repeat-containing protein 66 WDR66 Homo sapiens (Human) 1149 0 0 0 0 0 PF00400; Q8TBZ3 CHOYP_WDR20.1.1 m.31614 sp WDR20_HUMAN 51.536 586 238 13 5 568 3 564 0 587 WDR20_HUMAN reviewed WD repeat-containing protein 20 (Protein DMR) WDR20 Homo sapiens (Human) 569 0 0 0 0 0 PF00400; Q8TCJ2 CHOYP_STT3B.1.1 m.58945 sp STT3B_HUMAN 74.734 752 180 4 23 767 64 812 0 1174 STT3B_HUMAN reviewed Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) STT3B SIMP Homo sapiens (Human) 826 co-translational protein modification [GO:0043686]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; glycoprotein catabolic process [GO:0006516]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]; response to unfolded protein [GO:0006986] GO:0004579; GO:0005783; GO:0006516; GO:0006986; GO:0008250; GO:0016020; GO:0016021; GO:0018279; GO:0030433; GO:0043686; GO:0043687 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02516; Q8TD19 CHOYP_NEK9.1.1 m.19497 sp NEK9_HUMAN 47.229 830 378 13 29 841 49 835 0 756 NEK9_HUMAN reviewed Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) NEK9 KIAA1995 NEK8 NERCC Homo sapiens (Human) 979 cell division [GO:0051301]; chromosome segregation [GO:0007059]; microtubule-based process [GO:0007017]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope disassembly [GO:0007077]; protein phosphorylation [GO:0006468] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0006468; GO:0007017; GO:0007059; GO:0007067; GO:0007077; GO:0019901; GO:0046872; GO:0051301 0 0 0 PF00069;PF00415; Q8TD57 CHOYP_LOC100378331.1.1 m.47480 sp DYH3_HUMAN 64.889 4107 1356 18 13 4069 46 4116 0 5441 DYH3_HUMAN reviewed "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b)" DNAH3 DNAHC3B Homo sapiens (Human) 4116 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018 0 0 0 PF12780;PF08393;PF03028;PF12777; Q8TD57 CHOYP_LOC587136.3.3 m.33967 sp DYH3_HUMAN 62.967 1874 641 8 8 1879 2294 4116 0 2398 DYH3_HUMAN reviewed "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (HsADHC3) (Ciliary dynein heavy chain 3) (Dnahc3-b)" DNAH3 DNAHC3B Homo sapiens (Human) 4116 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018 0 0 0 PF12780;PF08393;PF03028;PF12777; Q8TDJ6 CHOYP_AGAP_AGAP010490.1.1 m.51445 sp DMXL2_HUMAN 40.572 3394 1562 83 33 3342 1 3023 0 2218 DMXL2_HUMAN reviewed DmX-like protein 2 (Rabconnectin-3) DMXL2 KIAA0856 Homo sapiens (Human) 3036 0 GO:0005615; GO:0008021; GO:0017137; GO:0030054; GO:0030672 0 0 0 PF12234;PF00400; Q8TDX5 CHOYP_LOC100377682.1.1 m.31441 sp ACMSD_HUMAN 70.536 336 98 1 24 358 1 336 0 520 ACMSD_HUMAN reviewed 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase) ACMSD Homo sapiens (Human) 336 picolinic acid biosynthetic process [GO:1905004]; protein oligomerization [GO:0051259]; quinolinate metabolic process [GO:0046874]; regulation of 'de novo' NAD biosynthetic process from tryptophan [GO:1905012]; regulation of quinolinate biosynthetic process [GO:1904984]; tryptophan catabolic process [GO:0006569] GO:0001760; GO:0005829; GO:0006569; GO:0008270; GO:0016787; GO:0046874; GO:0051259; GO:0070062; GO:1904984; GO:1905004; GO:1905012 PATHWAY: Secondary metabolite metabolism; quinolate metabolism. {ECO:0000305|PubMed:12140278}. 0 0 PF04909; Q8TE57 CHOYP_ATS18.1.2 m.20428 sp ATS16_HUMAN 42.429 1169 607 17 29 1138 59 1220 0 979 ATS16_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) ADAMTS16 KIAA2029 Homo sapiens (Human) 1224 branching involved in ureteric bud morphogenesis [GO:0001658]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] GO:0001658; GO:0003073; GO:0004222; GO:0005578; GO:0008270; GO:1902017 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q8TE60 CHOYP_ATS18.2.2 m.47828 sp ATS18_HUMAN 53.776 662 304 2 5 665 295 955 0 772 ATS18_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) ADAMTS18 ADAMTS21 Homo sapiens (Human) 1221 eye development [GO:0001654]; negative regulation of platelet aggregation [GO:0090331] GO:0001654; GO:0004222; GO:0005578; GO:0008270; GO:0090331 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q8TE60 CHOYP_BRAFLDRAFT_95556.2.2 m.21861 sp ATS18_HUMAN 45.476 840 422 12 38 855 61 886 0 751 ATS18_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) ADAMTS18 ADAMTS21 Homo sapiens (Human) 1221 eye development [GO:0001654]; negative regulation of platelet aggregation [GO:0090331] GO:0001654; GO:0004222; GO:0005578; GO:0008270; GO:0090331 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q8TE73 CHOYP_DNAH5.1.2 m.56799 sp DYH5_HUMAN 63.97 4635 1561 22 65 4606 6 4624 0 6130 DYH5_HUMAN reviewed "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)" DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) 4624 cilium assembly [GO:0042384]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]; sperm motility [GO:0030317] GO:0003341; GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005930; GO:0007368; GO:0007507; GO:0016887; GO:0021670; GO:0030317; GO:0036157; GO:0036158; GO:0042384 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8TE73 CHOYP_DNAH5.2.2 m.61452 sp DYH5_HUMAN 62.557 4631 1627 21 57 4592 6 4624 0 5986 DYH5_HUMAN reviewed "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)" DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) 4624 cilium assembly [GO:0042384]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]; sperm motility [GO:0030317] GO:0003341; GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005930; GO:0007368; GO:0007507; GO:0016887; GO:0021670; GO:0030317; GO:0036157; GO:0036158; GO:0042384 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8TE73 CHOYP_LOC577371.1.2 m.46335 sp DYH5_HUMAN 67.664 4648 1446 14 34 4667 20 4624 0 6527 DYH5_HUMAN reviewed "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (Ciliary dynein heavy chain 5)" DNAH5 DNAHC5 HL1 KIAA1603 Homo sapiens (Human) 4624 cilium assembly [GO:0042384]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]; sperm motility [GO:0030317] GO:0003341; GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005930; GO:0007368; GO:0007507; GO:0016887; GO:0021670; GO:0030317; GO:0036157; GO:0036158; GO:0042384 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8TEU7 CHOYP_BRAFLDRAFT_131151.3.4 m.57848 sp RPGF6_HUMAN 42.579 1334 616 25 35 1312 11 1250 0 971 RPGF6_HUMAN reviewed Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) RAPGEF6 PDZGEF2 Homo sapiens (Human) 1601 microvillus assembly [GO:0030033]; positive regulation of GTPase activity [GO:0043547]; protein localization to plasma membrane [GO:0072659]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087] GO:0005085; GO:0005829; GO:0005886; GO:0007265; GO:0016324; GO:0017016; GO:0030033; GO:0030139; GO:0030742; GO:0043087; GO:0043547; GO:0070300; GO:0072659 0 0 cd06224; PF00027;PF00595;PF00788;PF00617;PF00618; Q8TEU7 CHOYP_BRAFLDRAFT_131151.4.4 m.58019 sp RPGF6_HUMAN 46.18 1178 534 21 35 1164 11 1136 0 981 RPGF6_HUMAN reviewed Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) RAPGEF6 PDZGEF2 Homo sapiens (Human) 1601 microvillus assembly [GO:0030033]; positive regulation of GTPase activity [GO:0043547]; protein localization to plasma membrane [GO:0072659]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087] GO:0005085; GO:0005829; GO:0005886; GO:0007265; GO:0016324; GO:0017016; GO:0030033; GO:0030139; GO:0030742; GO:0043087; GO:0043547; GO:0070300; GO:0072659 0 0 cd06224; PF00027;PF00595;PF00788;PF00617;PF00618; Q8TF62 CHOYP_ATP8B2.2.3 m.41030 sp AT8B4_HUMAN 56.443 551 195 3 3 519 2 541 0 618 AT8B4_HUMAN reviewed Probable phospholipid-transporting ATPase IM (EC 3.6.3.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) ATP8B4 KIAA1939 Homo sapiens (Human) 1192 Golgi organization [GO:0007030] GO:0000287; GO:0004012; GO:0005524; GO:0005794; GO:0005886; GO:0007030; GO:0016021 0 0 0 PF00122;PF16212;PF16209; Q8UVC3 CHOYP_INVS.5.6 m.51685 sp INVS_CHICK 61.151 556 211 3 3 553 82 637 0 725 INVS_CHICK reviewed Inversin INVS Gallus gallus (Chicken) 1106 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005737; GO:0005856; GO:0007275; GO:0016055 0 0 0 PF12796;PF00612; Q8VC30 CHOYP_BRAFLDRAFT_115040.1.1 m.28389 sp TKFC_MOUSE 52.094 597 257 11 1 588 1 577 0 554 TKFC_MOUSE reviewed Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)] Tkfc Dak Mus musculus (Mouse) 578 carbohydrate phosphorylation [GO:0046835]; cellular carbohydrate metabolic process [GO:0044262]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol metabolic process [GO:0006071]; glycolytic process through fructose-1-phosphate [GO:0061625]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088] GO:0004371; GO:0005524; GO:0005634; GO:0006071; GO:0034012; GO:0039534; GO:0044262; GO:0045088; GO:0046835; GO:0046872; GO:0050354; GO:0061624; GO:0061625; GO:0070062 0 0 0 PF02733;PF02734; Q8VC42 CHOYP_BRAFLDRAFT_87849.1.1 m.8468 sp MIC1_MOUSE 54.923 650 280 5 8 648 6 651 0 701 MIC1_MOUSE reviewed Uncharacterized protein C18orf8 homolog (Colon cancer-associated protein Mic1) (Mic-1) Mic1 Mus musculus (Mouse) 657 0 GO:0005765 0 0 0 PF07035; Q8VDI9 CHOYP_ALG9.1.1 m.33297 sp ALG9_MOUSE 56.897 580 246 2 12 588 27 605 0 711 ALG9_MOUSE reviewed "Alpha-1,2-mannosyltransferase ALG9 (EC 2.4.1.259) (EC 2.4.1.261) (Asparagine-linked glycosylation protein 9 homolog) (Disrupted in bipolar disorder protein 1 homolog) (Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase) (Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase)" Alg9 Dibd1 Mus musculus (Mouse) 611 protein glycosylation [GO:0006486] GO:0000030; GO:0005783; GO:0005789; GO:0006486; GO:0016020; GO:0016021; GO:0052918; GO:0052926 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03901; Q8VDJ3 CHOYP_HDLBP.1.1 m.19891 sp VIGLN_MOUSE 51.838 789 368 6 2 779 242 1029 0 808 VIGLN_MOUSE reviewed Vigilin (High density lipoprotein-binding protein) (HDL-binding protein) Hdlbp Mus musculus (Mouse) 1268 cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869] GO:0005634; GO:0005737; GO:0006869; GO:0008203; GO:0034364; GO:0044822 0 0 0 PF00013; Q8VHE0 CHOYP_BRAFLDRAFT_284846.2.2 m.60100 sp SEC63_MOUSE 45.501 778 362 18 1 753 1 741 0 623 SEC63_MOUSE reviewed Translocation protein SEC63 homolog Sec63 Sec63l Mus musculus (Mouse) 760 liver development [GO:0001889]; multicellular organism aging [GO:0010259]; nitrogen compound metabolic process [GO:0006807]; posttranslational protein targeting to membrane [GO:0006620]; renal system development [GO:0072001]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0001889; GO:0005789; GO:0006614; GO:0006620; GO:0006807; GO:0010259; GO:0016020; GO:0016021; GO:0044822; GO:0072001 0 0 cd06257; PF00226;PF02889; Q8VHF0 CHOYP_ISCW_ISCW014579.1.2 m.235 sp MARK3_RAT 55.648 841 275 23 1 787 1 797 0 816 MARK3_RAT reviewed MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) Mark3 Rattus norvegicus (Rat) 797 establishment of cell polarity [GO:0030010]; microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0004674; GO:0005524; GO:0005886; GO:0030010 0 0 0 PF02149;PF00069;PF00627; Q8VHF0 CHOYP_ISCW_ISCW014579.2.2 m.5327 sp MARK3_RAT 55.399 852 287 25 1 814 1 797 0 815 MARK3_RAT reviewed MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) Mark3 Rattus norvegicus (Rat) 797 establishment of cell polarity [GO:0030010]; microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0004674; GO:0005524; GO:0005886; GO:0030010 0 0 0 PF02149;PF00069;PF00627; Q8VHK9 CHOYP_SI_DKEY-119O24.1.1.1 m.24940 sp DHX36_MOUSE 47.551 980 466 9 122 1095 47 984 0 869 DHX36_MOUSE reviewed ATP-dependent RNA helicase DHX36 (EC 3.6.4.13) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE) Dhx36 Ddx36 Kiaa1488 Mlel1 Mus musculus (Mouse) 1001 "ossification [GO:0001503]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RNA processing [GO:0006396]; RNA secondary structure unwinding [GO:0010501]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0001047; GO:0001503; GO:0002151; GO:0003725; GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006351; GO:0006396; GO:0008094; GO:0009615; GO:0010501; GO:0032206; GO:0042826; GO:0043330; GO:0044212; GO:0044822; GO:0045944; GO:0051880; GO:0070062 0 0 0 PF00270;PF04408;PF00271;PF07717; Q8VHY0 CHOYP_PHUM_PHUM210160.1.1 m.203 sp CSPG4_MOUSE 26.044 2204 1492 50 21 2149 30 2170 0 718 CSPG4_MOUSE reviewed Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Proteoglycan AN2) Cspg4 An2 Kiaa4232 Ng2 Mus musculus (Mouse) 2327 activation of MAPK activity [GO:0000187]; angiogenesis [GO:0001525]; cell proliferation [GO:0008283]; glial cell migration [GO:0008347]; intracellular signal transduction [GO:0035556]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; tissue remodeling [GO:0048771]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000187; GO:0001525; GO:0004871; GO:0005622; GO:0005886; GO:0005887; GO:0005925; GO:0007169; GO:0008283; GO:0008347; GO:0009986; GO:0016324; GO:0019901; GO:0031258; GO:0035556; GO:0042995; GO:0048771; GO:0050731; GO:0070062 0 0 0 PF00054;PF02210; Q8VID6 CHOYP_PDE11.3.3 m.51375 sp PDE11_RAT 50 898 403 8 1 855 1 895 0 897 PDE11_RAT reviewed "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)" Pde11a Rattus norvegicus (Rat) 935 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; signal transduction [GO:0007165] GO:0004112; GO:0004118; GO:0005829; GO:0006198; GO:0007165; GO:0030552; GO:0030553; GO:0043204; GO:0046069; GO:0046872; GO:0047555 0 0 0 PF01590;PF00233; Q8WML3 CHOYP_KAT6B.1.2 m.10955 sp KAT6B_MACFA 48.964 772 308 15 9 762 3 706 0 718 KAT6B_MACFA reviewed "Histone acetyltransferase KAT6B (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4)" KAT6B MYST4 QflA-12408 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 1784 "histone acetylation [GO:0016573]; histone H3 acetylation [GO:0043966]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000786; GO:0003677; GO:0004402; GO:0006334; GO:0006351; GO:0008134; GO:0008270; GO:0016407; GO:0016573; GO:0043966; GO:0045892; GO:0045893; GO:0070776 0 0 0 PF00538;PF01853;PF00628; Q8WN55 CHOYP_PTBP1.1.2 m.48 sp PTBP1_BOVIN 57.278 529 201 7 61 569 8 531 0 558 PTBP1_BOVIN reviewed Polypyrimidine tract-binding protein 1 (PTB) PTBP1 Bos taurus (Bovine) 531 "mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0005634; GO:0006397; GO:0008380; GO:0016020; GO:0036002; GO:0044822; GO:0048025; GO:0051148; GO:0070062 0 0 0 PF00076; Q8WUH2 CHOYP_BRAFLDRAFT_268910.1.1 m.24966 sp TGFA1_HUMAN 46.714 852 450 4 1 850 2 851 0 844 TGFA1_HUMAN reviewed Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1) TGFBRAP1 Homo sapiens (Human) 860 "endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0005160; GO:0005769; GO:0006355; GO:0006886; GO:0007165; GO:0007179; GO:0008333; GO:0016020; GO:0033263; GO:0034058; GO:0046332 0 0 0 PF00637;PF00780;PF10366;PF10367; Q8WUM4 CHOYP_BRAFLDRAFT_129885.1.2 m.24564 sp PDC6I_HUMAN 50.815 736 356 3 1 734 1 732 0 758 PDC6I_HUMAN reviewed Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) PDCD6IP AIP1 ALIX KIAA1375 Homo sapiens (Human) 868 apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell separation after cytokinesis [GO:0000920]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058] GO:0000920; GO:0001772; GO:0005737; GO:0005815; GO:0005829; GO:0005925; GO:0006915; GO:0007049; GO:0010824; GO:0015031; GO:0016020; GO:0019058; GO:0031871; GO:0036258; GO:0039702; GO:0042470; GO:0042803; GO:0043209; GO:0048306; GO:0070062; GO:0070971; GO:0090611; GO:1903543; GO:1903551; GO:1903553; GO:1903561 0 0 0 PF13949;PF03097; Q8WUM4 CHOYP_BRAFLDRAFT_129885.2.2 m.34895 sp PDC6I_HUMAN 46.501 886 407 13 1 837 1 868 0 757 PDC6I_HUMAN reviewed Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) PDCD6IP AIP1 ALIX KIAA1375 Homo sapiens (Human) 868 apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell separation after cytokinesis [GO:0000920]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058] GO:0000920; GO:0001772; GO:0005737; GO:0005815; GO:0005829; GO:0005925; GO:0006915; GO:0007049; GO:0010824; GO:0015031; GO:0016020; GO:0019058; GO:0031871; GO:0036258; GO:0039702; GO:0042470; GO:0042803; GO:0043209; GO:0048306; GO:0070062; GO:0070971; GO:0090611; GO:1903543; GO:1903551; GO:1903553; GO:1903561 0 0 0 PF13949;PF03097; Q8WUQ7 CHOYP_CATIN.1.1 m.42909 sp CATIN_HUMAN 59.084 633 223 5 118 744 144 746 0 726 CATIN_HUMAN reviewed Cactin (Renal carcinoma antigen NY-REN-24) CACTIN C19orf29 Homo sapiens (Human) 758 "cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; innate immune response [GO:0045087]; mRNA splicing, via spliceosome [GO:0000398]; multicellular organism development [GO:0007275]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]" GO:0000398; GO:0001933; GO:0005634; GO:0005654; GO:0005737; GO:0007275; GO:0031665; GO:0032088; GO:0032688; GO:0032717; GO:0032720; GO:0034122; GO:0044822; GO:0045087; GO:0060339; GO:0070062; GO:0071013; GO:0071222; GO:0071347; GO:0071356 0 0 0 PF10312;PF09732; Q8WVM7 CHOYP_ISCW_ISCW017188.1.1 m.23179 sp STAG1_HUMAN 51.61 1211 514 20 42 1202 3 1191 0 1180 STAG1_HUMAN reviewed Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) STAG1 SA1 Homo sapiens (Human) 1258 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; protein sumoylation [GO:0016925]; sister chromatid cohesion [GO:0007062] GO:0000775; GO:0000785; GO:0001228; GO:0003682; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0007062; GO:0007067; GO:0016925; GO:0051301 0 0 0 PF08514; Q8WVM8 CHOYP_LOC586005.1.1 m.63556 sp SCFD1_HUMAN 66.981 636 196 6 13 641 14 642 0 884 SCFD1_HUMAN reviewed Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2) SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23 Homo sapiens (Human) 642 "cell morphogenesis [GO:0000902]; COPII vesicle coating [GO:0048208]; negative regulation of autophagosome assembly [GO:1902902]; phagocytosis [GO:0006909]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; toxin transport [GO:1901998]; vesicle docking involved in exocytosis [GO:0006904]" GO:0000902; GO:0001666; GO:0005789; GO:0005798; GO:0005801; GO:0005829; GO:0005886; GO:0006890; GO:0006892; GO:0006904; GO:0006909; GO:0009636; GO:0015031; GO:0017119; GO:0019905; GO:0032580; GO:0048208; GO:0051223; GO:0060628; GO:1901998; GO:1902902 0 0 0 PF00995; Q8WWZ7 CHOYP_TRIADDRAFT_53677.1.1 m.35290 sp ABCA5_HUMAN 34.221 1727 973 42 6 1687 12 1620 0 872 ABCA5_HUMAN reviewed ATP-binding cassette sub-family A member 5 ABCA5 KIAA1888 Homo sapiens (Human) 1642 cholesterol efflux [GO:0033344]; high-density lipoprotein particle remodeling [GO:0034375]; lipid transport [GO:0006869]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; reverse cholesterol transport [GO:0043691] GO:0000139; GO:0005524; GO:0005764; GO:0005765; GO:0005770; GO:0006869; GO:0010745; GO:0016021; GO:0031902; GO:0033344; GO:0034375; GO:0042626; GO:0043231; GO:0043691 0 0 0 PF00005; Q8WXA3 CHOYP_LOC100372467.1.1 m.42336 sp RUFY2_HUMAN 51.464 649 284 6 36 661 13 653 0 659 RUFY2_HUMAN reviewed RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related) RUFY2 KIAA1537 RABIP4R Homo sapiens (Human) 655 0 GO:0005634; GO:0046872 0 0 0 PF01363;PF02759; Q8WXW3 CHOYP_LOC100377791.1.1 m.4144 sp PIBF1_HUMAN 47.878 754 370 5 13 758 18 756 0 686 PIBF1_HUMAN reviewed Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90) PIBF1 C13orf24 PIBF Homo sapiens (Human) 757 activation of JAK1 kinase activity [GO:0010531]; immune system process [GO:0002376]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of tyrosine phosphorylation of Stat4 protein [GO:0042521]; nonmotile primary cilium assembly [GO:0035058]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of tyrosine phosphorylation of Stat6 protein [GO:0042526]; protein localization to centrosome [GO:0071539] GO:0002376; GO:0005136; GO:0005615; GO:0005634; GO:0005813; GO:0007080; GO:0010531; GO:0031393; GO:0032695; GO:0032733; GO:0032815; GO:0034451; GO:0035058; GO:0042521; GO:0042526; GO:0071539; GO:0090307 0 0 0 0 Q8WXX0 CHOYP_DNAH12.1.3 m.22374 sp DYH7_HUMAN 49.59 3658 1737 30 127 3738 165 3761 0 3610 DYH7_HUMAN reviewed "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2)" DNAH7 KIAA0944 Homo sapiens (Human) 4024 cilium movement [GO:0003341]; cilium or flagellum-dependent cell motility [GO:0001539]; inner dynein arm assembly [GO:0036159] GO:0001539; GO:0003341; GO:0003777; GO:0005509; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0005929; GO:0016887; GO:0036156; GO:0036159 0 0 0 PF12780;PF08393;PF03028;PF12777; Q8WXX0 CHOYP_DNAH7.2.2 m.46648 sp DYH7_HUMAN 68.68 4007 1224 11 23 4019 38 4023 0 5799 DYH7_HUMAN reviewed "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (hDHC2)" DNAH7 KIAA0944 Homo sapiens (Human) 4024 cilium movement [GO:0003341]; cilium or flagellum-dependent cell motility [GO:0001539]; inner dynein arm assembly [GO:0036159] GO:0001539; GO:0003341; GO:0003777; GO:0005509; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0005929; GO:0016887; GO:0036156; GO:0036159 0 0 0 PF12780;PF08393;PF03028;PF12777; Q8WZ42 CHOYP_LOC100367089.1.4 m.1387 sp TITIN_HUMAN 31.179 2383 1452 70 3 2297 16495 18777 0 892 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q8WZ42 CHOYP_LOC100367089.2.4 m.1909 sp TITIN_HUMAN 28.402 5225 3228 150 3879 8866 12947 17895 0 1524 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q8WZ42 CHOYP_PHUM_PHUM226120.4.7 m.29370 sp TITIN_HUMAN 28.738 6100 3749 183 3424 9249 12947 18722 0 1808 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q8WZ42 CHOYP_PHUM_PHUM226120.6.7 m.48915 sp TITIN_HUMAN 27.953 6028 3702 177 3055 8785 12947 18630 0 1714 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q8WZ42 CHOYP_TITIN.1.19 m.2115 sp TITIN_HUMAN 28.617 5378 3321 156 3973 9112 12947 18044 0 1599 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q8WZ42 CHOYP_TITIN.10.19 m.36745 sp TITIN_HUMAN 29.214 4936 3026 142 4830 9570 18433 23095 0 1606 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q8WZA2 CHOYP_LOC100373735.1.1 m.10322 sp RPGF4_HUMAN 59.595 839 311 7 94 923 191 1010 0 1034 RPGF4_HUMAN reviewed Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) RAPGEF4 CGEF2 EPAC2 Homo sapiens (Human) 1011 calcium ion regulated exocytosis [GO:0017156]; cAMP-mediated signaling [GO:0019933]; G-protein coupled receptor signaling pathway [GO:0007186]; insulin secretion [GO:0030073]; regulation of exocytosis [GO:0017157]; regulation of insulin secretion [GO:0050796]; small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005088; GO:0005829; GO:0005886; GO:0007186; GO:0007264; GO:0016020; GO:0017016; GO:0017156; GO:0017157; GO:0019933; GO:0030073; GO:0030552; GO:0050796 0 0 cd06224; PF00027;PF00610;PF00617;PF00618; Q90474 CHOYP_HS90A.2.3 m.21992 sp H90A1_DANRE 71.275 651 168 6 4 643 83 725 0 939 H90A1_DANRE reviewed Heat shock protein HSP 90-alpha 1 hsp90a.1 hsp90 hsp90a hsp90aa1 zgc:86652 Danio rerio (Zebrafish) (Brachydanio rerio) 725 leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; myofibril assembly [GO:0030239]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein folding [GO:0006457]; response to metal ion [GO:0010038]; response to stress [GO:0006950]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; skeletal myofibril assembly [GO:0014866]; striated muscle myosin thick filament assembly [GO:0071688] GO:0005524; GO:0006457; GO:0006950; GO:0007517; GO:0010038; GO:0014866; GO:0030018; GO:0030235; GO:0030239; GO:0030240; GO:0030241; GO:0031672; GO:0042470; GO:0045429; GO:0048471; GO:0048769; GO:0050900; GO:0071688 0 0 0 PF02518;PF00183; Q90474 CHOYP_HS90A.3.3 m.28299 sp H90A1_DANRE 77.655 631 135 5 21 647 97 725 0 983 H90A1_DANRE reviewed Heat shock protein HSP 90-alpha 1 hsp90a.1 hsp90 hsp90a hsp90aa1 zgc:86652 Danio rerio (Zebrafish) (Brachydanio rerio) 725 leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; myofibril assembly [GO:0030239]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein folding [GO:0006457]; response to metal ion [GO:0010038]; response to stress [GO:0006950]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; skeletal myofibril assembly [GO:0014866]; striated muscle myosin thick filament assembly [GO:0071688] GO:0005524; GO:0006457; GO:0006950; GO:0007517; GO:0010038; GO:0014866; GO:0030018; GO:0030235; GO:0030239; GO:0030240; GO:0030241; GO:0031672; GO:0042470; GO:0045429; GO:0048471; GO:0048769; GO:0050900; GO:0071688 0 0 0 PF02518;PF00183; Q90474 CHOYP_HSP90AA1.1.1 m.14867 sp H90A1_DANRE 78.488 688 144 3 1 685 1 687 0 1094 H90A1_DANRE reviewed Heat shock protein HSP 90-alpha 1 hsp90a.1 hsp90 hsp90a hsp90aa1 zgc:86652 Danio rerio (Zebrafish) (Brachydanio rerio) 725 leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; myofibril assembly [GO:0030239]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein folding [GO:0006457]; response to metal ion [GO:0010038]; response to stress [GO:0006950]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; skeletal myofibril assembly [GO:0014866]; striated muscle myosin thick filament assembly [GO:0071688] GO:0005524; GO:0006457; GO:0006950; GO:0007517; GO:0010038; GO:0014866; GO:0030018; GO:0030235; GO:0030239; GO:0030240; GO:0030241; GO:0031672; GO:0042470; GO:0045429; GO:0048471; GO:0048769; GO:0050900; GO:0071688 0 0 0 PF02518;PF00183; Q90593 CHOYP_GRP78.5.5 m.51622 sp GRP78_CHICK 57.525 598 249 2 27 619 28 625 0 686 GRP78_CHICK reviewed 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) HSPA5 GRP78 Gallus gallus (Chicken) 652 "activation of signaling protein activity involved in unfolded protein response [GO:0006987]; ATP metabolic process [GO:0046034]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; ER overload response [GO:0006983]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of fibril organization [GO:1902904]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; protein refolding [GO:0042026]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of protein stability [GO:0031647]; substantia nigra development [GO:0021762]; toxin transport [GO:1901998]" GO:0000151; GO:0000974; GO:0001664; GO:0001948; GO:0005524; GO:0005615; GO:0005634; GO:0005788; GO:0005793; GO:0005829; GO:0005886; GO:0005925; GO:0006983; GO:0006987; GO:0008180; GO:0009986; GO:0016020; GO:0016887; GO:0019899; GO:0021589; GO:0021680; GO:0021762; GO:0023026; GO:0030176; GO:0030335; GO:0030496; GO:0030512; GO:0030529; GO:0031072; GO:0031398; GO:0031625; GO:0031647; GO:0034663; GO:0035437; GO:0042026; GO:0042149; GO:0043022; GO:0043066; GO:0043209; GO:0044822; GO:0045892; GO:0046034; GO:0051082; GO:0051603; GO:0055131; GO:0070062; GO:0071353; GO:0072562; GO:1901998; GO:1902904 0 0 0 PF00012; Q90687 CHOYP_PTN11.3.4 m.58091 sp PTN11_CHICK 62.034 590 171 7 26 601 4 554 0 695 PTN11_CHICK reviewed Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (SH-PTP2) (cSH-PTP2) PTPN11 Gallus gallus (Chicken) 593 abortive mitotic cell cycle [GO:0033277]; activation of MAPK activity [GO:0000187]; atrioventricular canal development [GO:0036302]; axonogenesis [GO:0007409]; Bergmann glial cell differentiation [GO:0060020]; cerebellar cortex formation [GO:0021697]; DNA damage checkpoint [GO:0000077]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; face morphogenesis [GO:0060325]; genitalia development [GO:0048806]; glucose homeostasis [GO:0042593]; homeostasis of number of cells within a tissue [GO:0048873]; hormone-mediated signaling pathway [GO:0009755]; hormone metabolic process [GO:0042445]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; intestinal epithelial cell migration [GO:0061582]; megakaryocyte development [GO:0035855]; microvillus organization [GO:0032528]; multicellular organismal reproductive process [GO:0048609]; multicellular organism growth [GO:0035264]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cortisol secretion [GO:0051463]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of insulin secretion [GO:0046676]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ growth [GO:0035265]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet formation [GO:0030220]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of hormone secretion [GO:0046887]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of multicellular organism growth [GO:0040014]; regulation of protein complex assembly [GO:0043254]; regulation of protein export from nucleus [GO:0046825]; triglyceride metabolic process [GO:0006641] GO:0000077; GO:0000187; GO:0004725; GO:0004726; GO:0005634; GO:0005737; GO:0006641; GO:0007173; GO:0007229; GO:0007409; GO:0009755; GO:0021697; GO:0030220; GO:0032528; GO:0033277; GO:0033629; GO:0035264; GO:0035265; GO:0035855; GO:0036302; GO:0040014; GO:0042445; GO:0042593; GO:0043254; GO:0045931; GO:0046676; GO:0046825; GO:0046887; GO:0048008; GO:0048011; GO:0048013; GO:0048609; GO:0048806; GO:0048839; GO:0048873; GO:0051463; GO:0060020; GO:0060125; GO:0060325; GO:0061582; GO:0070374; GO:2001275 0 0 0 PF00017;PF00102; Q90687 CHOYP_PTN11.4.4 m.62827 sp PTN11_CHICK 64.664 566 171 8 15 566 4 554 0 707 PTN11_CHICK reviewed Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (SH-PTP2) (cSH-PTP2) PTPN11 Gallus gallus (Chicken) 593 abortive mitotic cell cycle [GO:0033277]; activation of MAPK activity [GO:0000187]; atrioventricular canal development [GO:0036302]; axonogenesis [GO:0007409]; Bergmann glial cell differentiation [GO:0060020]; cerebellar cortex formation [GO:0021697]; DNA damage checkpoint [GO:0000077]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; face morphogenesis [GO:0060325]; genitalia development [GO:0048806]; glucose homeostasis [GO:0042593]; homeostasis of number of cells within a tissue [GO:0048873]; hormone-mediated signaling pathway [GO:0009755]; hormone metabolic process [GO:0042445]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; intestinal epithelial cell migration [GO:0061582]; megakaryocyte development [GO:0035855]; microvillus organization [GO:0032528]; multicellular organismal reproductive process [GO:0048609]; multicellular organism growth [GO:0035264]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cortisol secretion [GO:0051463]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of insulin secretion [GO:0046676]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ growth [GO:0035265]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet formation [GO:0030220]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of hormone secretion [GO:0046887]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of multicellular organism growth [GO:0040014]; regulation of protein complex assembly [GO:0043254]; regulation of protein export from nucleus [GO:0046825]; triglyceride metabolic process [GO:0006641] GO:0000077; GO:0000187; GO:0004725; GO:0004726; GO:0005634; GO:0005737; GO:0006641; GO:0007173; GO:0007229; GO:0007409; GO:0009755; GO:0021697; GO:0030220; GO:0032528; GO:0033277; GO:0033629; GO:0035264; GO:0035265; GO:0035855; GO:0036302; GO:0040014; GO:0042445; GO:0042593; GO:0043254; GO:0045931; GO:0046676; GO:0046825; GO:0046887; GO:0048008; GO:0048011; GO:0048013; GO:0048609; GO:0048806; GO:0048839; GO:0048873; GO:0051463; GO:0060020; GO:0060125; GO:0060325; GO:0061582; GO:0070374; GO:2001275 0 0 0 PF00017;PF00102; Q90705 CHOYP_LOC100203564.1.1 m.22544 sp EF2_CHICK 75.32 859 193 6 18 858 1 858 0 1363 EF2_CHICK reviewed Elongation factor 2 (EF-2) EEF2 Gallus gallus (Chicken) 858 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; Q90805 CHOYP_CNGA1.1.1 m.50469 sp CNG1_CHICK 52.941 476 220 4 2 476 223 695 0 533 CNG1_CHICK reviewed Cyclic nucleotide-gated channel cone photoreceptor subunit alpha (CNG channel 1) (CNG-1) (CNG1) 0 Gallus gallus (Chicken) 735 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005216; GO:0007601; GO:0016021; GO:0030552; GO:0050896 0 0 0 PF16526;PF00027;PF00520; Q90922 CHOYP_NTN1.1.1 m.38782 sp NET1_CHICK 56.775 583 240 3 41 621 31 603 0 721 NET1_CHICK reviewed Netrin-1 NTN1 Gallus gallus (Chicken) 606 "anterior/posterior axon guidance [GO:0033564]; Cdc42 protein signal transduction [GO:0032488]; establishment of nucleus localization [GO:0040023]; inner ear morphogenesis [GO:0042472]; negative regulation of axon extension [GO:0030517]; neuron migration [GO:0001764]; positive regulation of axon extension [GO:0045773]; positive regulation of cell motility [GO:2000147]; positive regulation of cell proliferation [GO:0008284]; Ras protein signal transduction [GO:0007265]; regulation of cell migration [GO:0030334]; single organismal cell-cell adhesion [GO:0016337]; substrate-dependent cell migration, cell extension [GO:0006930]" GO:0001764; GO:0005604; GO:0005737; GO:0006930; GO:0007265; GO:0008284; GO:0016337; GO:0030334; GO:0030517; GO:0032488; GO:0033564; GO:0040023; GO:0042472; GO:0045773; GO:0071944; GO:2000147 0 0 0 PF00053;PF00055;PF01759; Q90941 CHOYP_PB1.2.6 m.11467 sp PB1_CHICK 41.555 1723 822 34 1 1630 1 1631 0 1202 PB1_CHICK reviewed Protein polybromo-1 PBRM1 PB1 Gallus gallus (Chicken) 1633 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0006355; GO:0016569 0 0 0 PF01426;PF00439;PF00505; Q90WU3 CHOYP_DDX1.1.1 m.46908 sp DDX1_CHICK 64.578 734 249 6 1 726 1 731 0 970 DDX1_CHICK reviewed ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) DDX1 Gallus gallus (Chicken) 740 "DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA secondary structure unwinding [GO:0010501]; transcription, DNA-templated [GO:0006351]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0003677; GO:0003682; GO:0003712; GO:0004004; GO:0004518; GO:0004527; GO:0005524; GO:0005634; GO:0005737; GO:0006302; GO:0006351; GO:0006355; GO:0006388; GO:0006397; GO:0008026; GO:0008143; GO:0010501; GO:0032508; GO:0033677; GO:0072669 0 0 0 PF00270;PF00271;PF00622; Q90XB6 CHOYP_SULF1.1.1 m.16881 sp SULF1_COTCO 42.63 882 393 14 7 824 6 838 0 704 SULF1_COTCO reviewed Extracellular sulfatase Sulf-1 (qSulf1) (EC 3.1.6.-) SULF1 Coturnix coturnix (Common quail) (Tetrao coturnix) 867 bone development [GO:0060348]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell adhesion [GO:0007155]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; limb joint morphogenesis [GO:0036022]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of prostatic bud formation [GO:0060686]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of Wnt signaling pathway [GO:0030177]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001502; GO:0001822; GO:0001937; GO:0002063; GO:0004065; GO:0005509; GO:0005615; GO:0005783; GO:0005794; GO:0005795; GO:0007155; GO:0008449; GO:0009986; GO:0014846; GO:0016525; GO:0030177; GO:0030201; GO:0030336; GO:0030513; GO:0035860; GO:0036022; GO:0040037; GO:0045121; GO:0048010; GO:0048661; GO:0048706; GO:0051216; GO:0060070; GO:0060348; GO:0060384; GO:0060686 0 0 0 PF12548;PF00884; Q90Y54 CHOYP_JAG1.2.3 m.31731 sp JAG1B_DANRE 49.306 1225 565 19 7 1207 16 1208 0 1170 JAG1B_DANRE reviewed Protein jagged-1b (Jagged1b) (Jagged3) jag1b jag3 Danio rerio (Zebrafish) (Brachydanio rerio) 1213 auditory receptor cell development [GO:0060117]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; dorsal/ventral pattern formation [GO:0009953]; face morphogenesis [GO:0060325]; fin regeneration [GO:0031101]; inner ear morphogenesis [GO:0042472]; liver development [GO:0001889]; Notch signaling pathway [GO:0007219]; otolith morphogenesis [GO:0032474]; pancreas development [GO:0031016]; semicircular canal development [GO:0060872]; semicircular canal morphogenesis [GO:0048752]; thyroid gland development [GO:0030878] GO:0001889; GO:0005509; GO:0007219; GO:0009953; GO:0016021; GO:0030878; GO:0031016; GO:0031101; GO:0032474; GO:0042472; GO:0048752; GO:0060117; GO:0060325; GO:0060351; GO:0060872 0 0 0 PF01414;PF00008;PF07645;PF12661;PF07657; Q90ZA1 CHOYP_PARN.1.1 m.19023 sp PARN_XENLA 46.701 591 290 8 16 591 1 581 0 545 PARN_XENLA reviewed Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) (parn-A) parn Xenopus laevis (African clawed frog) 631 meiotic cell cycle [GO:0051321]; mRNA catabolic process [GO:0006402] GO:0000166; GO:0003723; GO:0004535; GO:0005634; GO:0005737; GO:0006402; GO:0046872; GO:0051321 0 0 0 PF04857;PF01424;PF08675; Q90ZK6 CHOYP_ACVR1.2.2 m.44364 sp ACVR1_CHICK 54.234 496 197 8 46 531 20 495 0 521 ACVR1_CHICK reviewed Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (Type I TGF B receptor) ACVR1 Gallus gallus (Chicken) 504 "activin receptor signaling pathway [GO:0032924]; acute inflammatory response [GO:0002526]; atrial septum primum morphogenesis [GO:0003289]; BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell fate commitment [GO:0060923]; cell migration [GO:0016477]; cellular response to BMP stimulus [GO:0071773]; determination of left/right symmetry [GO:0007368]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion cell fate commitment [GO:0061445]; endothelial cell activation [GO:0042118]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; mesenchymal cell differentiation [GO:0048762]; mesoderm development [GO:0007498]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of signal transduction [GO:0009968]; neural crest cell migration [GO:0001755]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; patterning of blood vessels [GO:0001569]; peptidyl-threonine phosphorylation [GO:0018107]; pharyngeal system development [GO:0060037]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of ossification [GO:0030278]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000082; GO:0001569; GO:0001702; GO:0001707; GO:0001755; GO:0002526; GO:0003143; GO:0003183; GO:0003289; GO:0004672; GO:0004674; GO:0004702; GO:0005025; GO:0005057; GO:0005524; GO:0005622; GO:0005887; GO:0006468; GO:0007179; GO:0007281; GO:0007368; GO:0007369; GO:0007498; GO:0007507; GO:0009968; GO:0010694; GO:0010718; GO:0010862; GO:0016020; GO:0016361; GO:0016477; GO:0018107; GO:0019838; GO:0030278; GO:0030335; GO:0030501; GO:0030509; GO:0030513; GO:0032924; GO:0032926; GO:0035556; GO:0042118; GO:0042803; GO:0045177; GO:0045669; GO:0045893; GO:0045944; GO:0046332; GO:0046872; GO:0048179; GO:0048185; GO:0048762; GO:0050431; GO:0051145; GO:0060037; GO:0060317; GO:0060389; GO:0060923; GO:0061445; GO:0071773; GO:2000017; GO:2001237 0 0 0 PF07714;PF08515; Q91048 CHOYP_LOC100313712.1.1 m.7071 sp PTK7_CHICK 35.553 1066 630 23 26 1076 21 1044 0 639 PTK7_CHICK reviewed Inactive tyrosine-protein kinase 7 (Kinase-like protein) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7) PTK7 KLG Gallus gallus (Chicken) 1051 cell adhesion [GO:0007155]; convergent extension [GO:0060026]; establishment of planar polarity [GO:0001736]; neural tube closure [GO:0001843] GO:0001736; GO:0001843; GO:0004713; GO:0005524; GO:0005887; GO:0007155; GO:0060026; GO:1904929 0 0 0 PF07679;PF07714; Q91437 CHOYP_PYR1.1.1 m.61565 sp PYR1_SQUAC 67.92 2260 673 15 8 2237 4 2241 0 3138 PYR1_SQUAC reviewed CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] CAD Squalus acanthias (Spiny dogfish) 2242 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; glutamine metabolic process [GO:0006541] GO:0004070; GO:0004088; GO:0004151; GO:0005524; GO:0005634; GO:0005737; GO:0006207; GO:0006541; GO:0008270; GO:0016597; GO:0044205 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. 0 0 PF01979;PF02786;PF02787;PF00988;PF00117;PF02142;PF00185;PF02729; Q91447 CHOYP_LOC100742289.1.1 m.25180 sp MP2K1_SERCA 67.725 378 114 4 31 408 7 376 0 521 MP2K1_SERCA reviewed Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1) (Fragment) MAP2K1 MEK1 PRKMK1 Serinus canaria (Island canary) (Fringilla canaria) 388 0 GO:0004674; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005815 0 0 0 PF00069; Q91498 CHOYP_ISCW_ISCW022169.1.1 m.33154 sp VACHT_TORMA 56.016 507 200 5 17 521 22 507 0 547 VACHT_TORMA reviewed Vesicular acetylcholine transporter (VAChT) (Vesamicol-binding protein) 0 Torpedo marmorata (Marbled electric ray) 511 neurotransmitter transport [GO:0006836]; transmembrane transport [GO:0055085] GO:0006836; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q91766 CHOYP_LOC100023660.1.1 m.30865 sp HNF4A_XENLA 74.405 336 79 3 28 360 49 380 0 530 HNF4A_XENLA reviewed Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) hnf4a hnf4 nr2a1 Xenopus laevis (African clawed frog) 464 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; Q91766 CHOYP_LOC100879907.1.1 m.47418 sp HNF4A_XENLA 74.405 336 79 3 36 368 49 380 0 533 HNF4A_XENLA reviewed Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) hnf4a hnf4 nr2a1 Xenopus laevis (African clawed frog) 464 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; Q91766 CHOYP_LOC100879907.1.1 m.47419 sp HNF4A_XENLA 74.405 336 79 3 36 368 49 380 0 531 HNF4A_XENLA reviewed Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) hnf4a hnf4 nr2a1 Xenopus laevis (African clawed frog) 464 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; Q91821 CHOYP_MELK.1.1 m.7733 sp MELK_XENLA 47.467 691 294 12 1 664 3 651 0 608 MELK_XENLA reviewed Maternal embryonic leucine zipper kinase (MELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) melk Xenopus laevis (African clawed frog) 651 apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; hemopoiesis [GO:0030097]; neural precursor cell proliferation [GO:0061351]; positive regulation of apoptotic process [GO:0043065]; protein autophosphorylation [GO:0046777] GO:0004674; GO:0004715; GO:0005509; GO:0005524; GO:0005886; GO:0005938; GO:0006915; GO:0007049; GO:0008283; GO:0008289; GO:0030097; GO:0043065; GO:0046777; GO:0061351 0 0 0 PF02149;PF00069; Q91857 CHOYP_AAEL_AAEL006988.1.1 m.49733 sp TAF6_XENLA 54.921 508 212 5 9 502 5 509 0 563 TAF6_XENLA reviewed Transcription initiation factor TFIID subunit 6 (xTAF6) (Transcription initiation factor TFIID 60 kDa subunit) (TAF(II)60) (TAFII-60) (TAFII60) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) taf6 Xenopus laevis (African clawed frog) 618 "DNA-templated transcription, initiation [GO:0006352]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]" GO:0006352; GO:0051090; GO:0071339 0 0 0 PF02969;PF07571; Q91880 CHOYP_SUH.1.1 m.28586 sp SUH_XENLA 80.963 457 82 1 164 615 28 484 0 798 SUH_XENLA reviewed Suppressor of hairless protein homolog (X-Su(H)) rbpj rbpsuh suh Xenopus laevis (African clawed frog) 501 "multicellular organism development [GO:0007275]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0000982; GO:0005634; GO:0005737; GO:0006351; GO:0007221; GO:0007275; GO:0043565; GO:0061419 0 0 0 PF09270;PF09271;PF01833; Q91883 CHOYP_GRP78.1.5 m.22771 sp GRP78_XENLA 53.141 589 274 1 40 628 32 618 0 616 GRP78_XENLA reviewed 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP) hspa5 Xenopus laevis (African clawed frog) 658 0 GO:0005524; GO:0005788 0 0 0 PF00012; Q91V09 CHOYP_WDR13.1.1 m.55091 sp WDR13_MOUSE 58.487 489 191 6 5 485 1 485 0 605 WDR13_MOUSE reviewed WD repeat-containing protein 13 Wdr13 Mus musculus (Mouse) 485 negative regulation of type B pancreatic cell proliferation [GO:1904691] GO:0005654; GO:0005737; GO:1904691; GO:1990841 0 0 0 PF00400; Q91V92 CHOYP_ACLY.1.1 m.65081 sp ACLY_MOUSE 73.266 1096 285 4 1 1093 1 1091 0 1688 ACLY_MOUSE reviewed ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) Acly Mus musculus (Mouse) 1091 acetyl-CoA biosynthetic process [GO:0006085]; citrate metabolic process [GO:0006101]; lipid biosynthetic process [GO:0008610]; oxaloacetate metabolic process [GO:0006107] GO:0003878; GO:0005524; GO:0005654; GO:0005737; GO:0005739; GO:0005886; GO:0006085; GO:0006101; GO:0006107; GO:0008610; GO:0016020; GO:0046872; GO:0048037; GO:0070062 0 0 0 PF16114;PF00285;PF02629;PF00549; Q91VD9 CHOYP_LOC582178.1.1 m.42729 sp NDUS1_MOUSE 70.799 726 204 4 20 744 1 719 0 1090 NDUS1_MOUSE reviewed "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-75kD) (CI-75kD)" Ndufs1 Mus musculus (Mouse) 727 apoptotic mitochondrial changes [GO:0008637]; ATP metabolic process [GO:0046034]; ATP synthesis coupled electron transport [GO:0042773]; cellular respiration [GO:0045333]; reactive oxygen species metabolic process [GO:0072593]; regulation of mitochondrial membrane potential [GO:0051881] GO:0005739; GO:0005747; GO:0005758; GO:0008137; GO:0008637; GO:0009055; GO:0042773; GO:0043209; GO:0045333; GO:0046034; GO:0046872; GO:0051537; GO:0051539; GO:0051881; GO:0072593 0 0 cd00207; PF00384;PF10588;PF09326; Q91VN6 CHOYP_DDX41.1.1 m.16719 sp DDX41_MOUSE 76.596 564 129 1 64 624 59 622 0 889 DDX41_MOUSE reviewed Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) Ddx41 Mus musculus (Mouse) 622 "cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cellular response to interferon-beta [GO:0035458]; defense response to virus [GO:0051607]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; RNA secondary structure unwinding [GO:0010501]" GO:0000398; GO:0003677; GO:0004004; GO:0005524; GO:0005634; GO:0005783; GO:0008283; GO:0010501; GO:0016020; GO:0030154; GO:0035458; GO:0044822; GO:0045944; GO:0046872; GO:0051607; GO:0071013 0 0 0 PF00270;PF00271; Q91VS8 CHOYP_FARP2.1.1 m.9404 sp FARP2_MOUSE 56.923 520 214 5 594 1105 514 1031 0 596 FARP2_MOUSE reviewed "FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR)" Farp2 Kiaa0793 Mus musculus (Mouse) 1065 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; neuron remodeling [GO:0016322]; osteoclast differentiation [GO:0030316]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; regulation of integrin activation [GO:0033623]; regulation of Rho protein signal transduction [GO:0035023]; semaphorin-plexin signaling pathway [GO:0071526] GO:0005089; GO:0005737; GO:0005829; GO:0005856; GO:0007155; GO:0016322; GO:0016601; GO:0019898; GO:0030316; GO:0030676; GO:0031532; GO:0033623; GO:0035023; GO:0071526; GO:0071800 0 0 0 PF08736;PF09380;PF00373;PF09379;PF00169;PF00621; Q91VU6 CHOYP_DCA11.1.1 m.56742 sp DCA11_MOUSE 53.593 487 214 4 31 505 41 527 0 548 DCA11_MOUSE reviewed DDB1- and CUL4-associated factor 11 (WD repeat-containing protein 23) Dcaf11 D14Ucla1 Wdr23 Mus musculus (Mouse) 549 protein ubiquitination [GO:0016567] GO:0005654; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q91W89 CHOYP_MA2C1.1.1 m.46709 sp MA2C1_MOUSE 52.034 1057 467 11 6 1053 7 1032 0 1051 MA2C1_MOUSE reviewed Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) Man2c1 Mus musculus (Mouse) 1039 mannose metabolic process [GO:0006013]; protein deglycosylation [GO:0006517] GO:0004559; GO:0005773; GO:0006013; GO:0006517; GO:0008270; GO:0030246 0 0 0 PF09261;PF01074;PF07748; Q91WF7 CHOYP_FIG4.1.2 m.64881 sp FIG4_MOUSE 48.173 903 428 12 5 870 7 906 0 833 FIG4_MOUSE reviewed "Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)" Fig4 Kiaa0274 Sac3 Mus musculus (Mouse) 907 locomotory behavior [GO:0007626]; myelin assembly [GO:0032288]; negative regulation of myelination [GO:0031642]; neuron development [GO:0048666]; phosphatidylinositol metabolic process [GO:0046488]; pigmentation [GO:0043473]; positive regulation of neuron projection development [GO:0010976]; vacuole organization [GO:0007033] GO:0004438; GO:0005783; GO:0005794; GO:0007033; GO:0007626; GO:0010008; GO:0010976; GO:0031642; GO:0032288; GO:0034593; GO:0043473; GO:0043812; GO:0046488; GO:0048666; GO:0055037 0 0 0 PF02383; Q91WT9 CHOYP_CBS.1.2 m.54537 sp CBS_MOUSE 61.914 533 179 4 15 533 38 560 0 694 CBS_MOUSE reviewed Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) Cbs Mus musculus (Mouse) 561 blood vessel remodeling [GO:0001974]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular amino acid biosynthetic process [GO:0008652]; cellular response to hypoxia [GO:0071456]; cerebellum morphogenesis [GO:0021587]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343]; endochondral ossification [GO:0001958]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; hydrogen sulfide biosynthetic process [GO:0070814]; L-serine metabolic process [GO:0006563]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of apoptotic process [GO:0043066]; regulation of blood vessel size [GO:0050880]; regulation of cGMP metabolic process [GO:0030823]; regulation of JUN kinase activity [GO:0043506]; response to folic acid [GO:0051593]; superoxide metabolic process [GO:0006801]; transsulfuration [GO:0019346] GO:0001958; GO:0001974; GO:0004122; GO:0004124; GO:0005634; GO:0005737; GO:0005829; GO:0006535; GO:0006563; GO:0006801; GO:0008652; GO:0019343; GO:0019344; GO:0019346; GO:0019825; GO:0019899; GO:0020037; GO:0021587; GO:0030170; GO:0030823; GO:0031625; GO:0042802; GO:0042803; GO:0043066; GO:0043418; GO:0043506; GO:0046872; GO:0050421; GO:0050667; GO:0050880; GO:0051593; GO:0060135; GO:0060351; GO:0070025; GO:0070026; GO:0070814; GO:0071456; GO:0072341; GO:1904047 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. {ECO:0000250|UniProtKB:P35520}. 0 0 PF00571;PF00291; Q91WT9 CHOYP_CBS.2.2 m.65898 sp CBS_MOUSE 61.914 533 179 4 15 533 38 560 0 694 CBS_MOUSE reviewed Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) Cbs Mus musculus (Mouse) 561 blood vessel remodeling [GO:0001974]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular amino acid biosynthetic process [GO:0008652]; cellular response to hypoxia [GO:0071456]; cerebellum morphogenesis [GO:0021587]; cysteine biosynthetic process [GO:0019344]; cysteine biosynthetic process from serine [GO:0006535]; cysteine biosynthetic process via cystathionine [GO:0019343]; endochondral ossification [GO:0001958]; homocysteine catabolic process [GO:0043418]; homocysteine metabolic process [GO:0050667]; hydrogen sulfide biosynthetic process [GO:0070814]; L-serine metabolic process [GO:0006563]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of apoptotic process [GO:0043066]; regulation of blood vessel size [GO:0050880]; regulation of cGMP metabolic process [GO:0030823]; regulation of JUN kinase activity [GO:0043506]; response to folic acid [GO:0051593]; superoxide metabolic process [GO:0006801]; transsulfuration [GO:0019346] GO:0001958; GO:0001974; GO:0004122; GO:0004124; GO:0005634; GO:0005737; GO:0005829; GO:0006535; GO:0006563; GO:0006801; GO:0008652; GO:0019343; GO:0019344; GO:0019346; GO:0019825; GO:0019899; GO:0020037; GO:0021587; GO:0030170; GO:0030823; GO:0031625; GO:0042802; GO:0042803; GO:0043066; GO:0043418; GO:0043506; GO:0046872; GO:0050421; GO:0050667; GO:0050880; GO:0051593; GO:0060135; GO:0060351; GO:0070025; GO:0070026; GO:0070814; GO:0071456; GO:0072341; GO:1904047 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2. {ECO:0000250|UniProtKB:P35520}. 0 0 PF00571;PF00291; Q91X83 CHOYP_METK1.1.2 m.59870 sp METK1_MOUSE 73.698 384 101 0 464 847 13 396 0 602 METK1_MOUSE reviewed S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) Mat1a Mus musculus (Mouse) 396 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0005829; GO:0006556; GO:0006730; GO:0046872 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q91X83 CHOYP_METK1.2.2 m.65101 sp METK1_MOUSE 74.211 380 98 0 38 417 17 396 0 595 METK1_MOUSE reviewed S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) Mat1a Mus musculus (Mouse) 396 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0005829; GO:0006556; GO:0006730; GO:0046872 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q91XL9 CHOYP_OSBL1.1.1 m.24569 sp OSBL1_MOUSE 44.885 958 501 11 36 980 7 950 0 808 OSBL1_MOUSE reviewed Oxysterol-binding protein-related protein 1 (ORP-1) (OSBP-related protein 1) Osbpl1a Orp1 Orp1a Orp1l Mus musculus (Mouse) 950 lipid transport [GO:0006869] GO:0005634; GO:0005654; GO:0005737; GO:0005770; GO:0006869; GO:0015485; GO:0070062 0 0 0 PF12796;PF01237; Q91XQ0 CHOYP_DYH8.2.2 m.45091 sp DYH8_MOUSE 65.285 4632 1568 19 28 4644 121 4727 0 6304 DYH8_MOUSE reviewed "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" Dnah8 Dnahc8 Mus musculus (Mouse) 4731 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0030286; GO:0036157; GO:0097228 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q91XU0 CHOYP_LOC101169976.1.1 m.55723 sp WRIP1_MOUSE 58.486 436 161 3 161 577 221 655 0 546 WRIP1_MOUSE reviewed ATPase WRNIP1 (EC 3.6.1.3) (Werner helicase-interacting protein 1) Wrnip1 Whip Mus musculus (Mouse) 660 DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000731; GO:0000781; GO:0003677; GO:0005524; GO:0005634; GO:0006260; GO:0016020; GO:0016887; GO:0030174; GO:0042802; GO:0048471 0 0 0 PF00004;PF16193;PF12002; Q91YE6 CHOYP_IPO9.1.4 m.24013 sp IPO9_MOUSE 60.328 1036 392 6 5 1030 15 1041 0 1310 IPO9_MOUSE reviewed Importin-9 (Imp9) (Importin-9a) (Imp9a) (Importin-9b) (Imp9b) (Ran-binding protein 9) (RanBP9) Ipo9 Imp9 Ranbp9 Mus musculus (Mouse) 1041 protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; ribosomal protein import into nucleus [GO:0006610]; ribosome biogenesis [GO:0042254]; transcription factor import into nucleus [GO:0042991] GO:0005635; GO:0005737; GO:0005829; GO:0006606; GO:0006610; GO:0008536; GO:0008565; GO:0016020; GO:0042254; GO:0042393; GO:0042991; GO:0050821 0 0 0 PF03810; Q91YK0 CHOYP_BRAFLDRAFT_67566.4.4 m.49075 sp LRC49_MOUSE 47.683 669 294 9 144 807 65 682 0 593 LRC49_MOUSE reviewed Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79) Lrrc49 Mus musculus (Mouse) 686 0 GO:0005737; GO:0005874 0 0 0 0 Q91YN5 CHOYP_BRAFLDRAFT_125327.1.1 m.29699 sp UAP1_MOUSE 55.598 518 217 9 1 511 1 512 0 589 UAP1_MOUSE reviewed UDP-N-acetylhexosamine pyrophosphorylase [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23)] Uap1 Mus musculus (Mouse) 522 UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0003977; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006048; GO:0042802 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1. 0 0 PF01704; Q91YQ5 CHOYP_BRAFLDRAFT_283789.1.1 m.40987 sp RPN1_MOUSE 52.677 579 265 5 30 601 32 608 0 652 RPN1_MOUSE reviewed Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) Rpn1 Mus musculus (Mouse) 608 protein N-linked glycosylation via asparagine [GO:0018279] GO:0004579; GO:0005789; GO:0005791; GO:0008250; GO:0016020; GO:0016021; GO:0018279; GO:0042470; GO:0044822 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04597; Q91YR5 CHOYP_BRAFLDRAFT_204501.1.1 m.910 sp MET13_MOUSE 46.472 652 319 8 1 623 1 651 0 597 MET13_MOUSE reviewed Methyltransferase-like protein 13 (EC 2.1.1.-) Mettl13 Kiaa0859 Mus musculus (Mouse) 698 0 GO:0008168 0 0 0 PF08241; Q91ZA3 CHOYP_PCCA.2.2 m.45684 sp PCCA_MOUSE 62.908 674 250 0 55 728 51 724 0 889 PCCA_MOUSE reviewed "Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)" Pcca Mus musculus (Mouse) 724 0 GO:0004075; GO:0004658; GO:0005524; GO:0005739; GO:0005759; GO:0019899; GO:0046872 PATHWAY: Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. 0 0 PF02785;PF00289;PF00364;PF02786; Q91ZS8 CHOYP_RED1.2.2 m.61084 sp RED1_MOUSE 60.34 648 227 6 185 805 67 711 0 778 RED1_MOUSE reviewed Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) Adarb1 Adar2 Red1 Mus musculus (Mouse) 711 adenosine to inosine editing [GO:0006382]; mRNA processing [GO:0006397]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; positive regulation of viral genome replication [GO:0045070]; regulation of cell cycle [GO:0051726]; RNA processing [GO:0006396] GO:0003723; GO:0003725; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006396; GO:0006397; GO:0008285; GO:0030336; GO:0044387; GO:0044822; GO:0045070; GO:0046872; GO:0051726 0 0 0 PF02137;PF00035; Q91ZU6 CHOYP_DYST.1.2 m.23274 sp DYST_MOUSE 31.836 1247 763 17 2 1191 6115 7331 0 655 DYST_MOUSE reviewed Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) 7393 axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; intermediate filament cytoskeleton organization [GO:0045104]; intracellular transport [GO:0046907]; retrograde axonal transport [GO:0008090] GO:0001725; GO:0005509; GO:0005634; GO:0005635; GO:0005737; GO:0005789; GO:0005882; GO:0005925; GO:0005938; GO:0007155; GO:0007409; GO:0008090; GO:0009898; GO:0014069; GO:0014704; GO:0015629; GO:0015630; GO:0016020; GO:0016021; GO:0016023; GO:0030018; GO:0030056; GO:0031673; GO:0035371; GO:0042383; GO:0042803; GO:0045104; GO:0046907; GO:0048471; GO:0051010; GO:0097038; GO:1904115 0 0 0 PF00307;PF13499;PF02187;PF00681;PF00435; Q91ZU6 CHOYP_LOC100118464.1.1 m.33259 sp DYST_MOUSE 32.634 3717 2341 38 3094 6741 3756 7378 0 1883 DYST_MOUSE reviewed Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) 7393 axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; intermediate filament cytoskeleton organization [GO:0045104]; intracellular transport [GO:0046907]; retrograde axonal transport [GO:0008090] GO:0001725; GO:0005509; GO:0005634; GO:0005635; GO:0005737; GO:0005789; GO:0005882; GO:0005925; GO:0005938; GO:0007155; GO:0007409; GO:0008090; GO:0009898; GO:0014069; GO:0014704; GO:0015629; GO:0015630; GO:0016020; GO:0016021; GO:0016023; GO:0030018; GO:0030056; GO:0031673; GO:0035371; GO:0042383; GO:0042803; GO:0045104; GO:0046907; GO:0048471; GO:0051010; GO:0097038; GO:1904115 0 0 0 PF00307;PF13499;PF02187;PF00681;PF00435; Q91ZU6 CHOYP_LOC100647948.1.1 m.9650 sp DYST_MOUSE 26.387 2361 1510 40 1258 3483 5125 7392 0 816 DYST_MOUSE reviewed Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) 7393 axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; intermediate filament cytoskeleton organization [GO:0045104]; intracellular transport [GO:0046907]; retrograde axonal transport [GO:0008090] GO:0001725; GO:0005509; GO:0005634; GO:0005635; GO:0005737; GO:0005789; GO:0005882; GO:0005925; GO:0005938; GO:0007155; GO:0007409; GO:0008090; GO:0009898; GO:0014069; GO:0014704; GO:0015629; GO:0015630; GO:0016020; GO:0016021; GO:0016023; GO:0030018; GO:0030056; GO:0031673; GO:0035371; GO:0042383; GO:0042803; GO:0045104; GO:0046907; GO:0048471; GO:0051010; GO:0097038; GO:1904115 0 0 0 PF00307;PF13499;PF02187;PF00681;PF00435; Q91ZU6 CHOYP_LOC662585.2.2 m.7262 sp DYST_MOUSE 32.377 3765 2378 39 1737 5432 3713 7378 0 1882 DYST_MOUSE reviewed Dystonin (Bullous pemphigoid antigen 1) (BPA) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) (Microtubule actin cross-linking factor 2) Dst Bpag1 Macf2 Mus musculus (Mouse) 7393 axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; intermediate filament cytoskeleton organization [GO:0045104]; intracellular transport [GO:0046907]; retrograde axonal transport [GO:0008090] GO:0001725; GO:0005509; GO:0005634; GO:0005635; GO:0005737; GO:0005789; GO:0005882; GO:0005925; GO:0005938; GO:0007155; GO:0007409; GO:0008090; GO:0009898; GO:0014069; GO:0014704; GO:0015629; GO:0015630; GO:0016020; GO:0016021; GO:0016023; GO:0030018; GO:0030056; GO:0031673; GO:0035371; GO:0042383; GO:0042803; GO:0045104; GO:0046907; GO:0048471; GO:0051010; GO:0097038; GO:1904115 0 0 0 PF00307;PF13499;PF02187;PF00681;PF00435; Q91ZX7 CHOYP_LRP1.2.5 m.12375 sp LRP1_MOUSE 35.218 1468 766 46 1 1376 3134 4508 0 786 LRP1_MOUSE reviewed Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] Lrp1 A2mr Mus musculus (Mouse) 4545 aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; beta-amyloid clearance [GO:0097242]; cardiac septum development [GO:0003279]; cholesterol metabolic process [GO:0008203]; coronary vasculature development [GO:0060976]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of lipid transport [GO:0032370]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of phospholipase A2 activity [GO:0032429] GO:0003279; GO:0005509; GO:0005730; GO:0005737; GO:0005765; GO:0005887; GO:0005905; GO:0005925; GO:0006898; GO:0008203; GO:0010875; GO:0014912; GO:0016020; GO:0030178; GO:0032370; GO:0032374; GO:0032403; GO:0032429; GO:0032956; GO:0034185; GO:0035909; GO:0043235; GO:0043277; GO:0044822; GO:0048471; GO:0060976; GO:0097242; GO:2000587 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q91ZX7 CHOYP_LRP1.3.5 m.15680 sp LRP1_MOUSE 35.433 1397 745 49 1 1320 3192 4508 0 738 LRP1_MOUSE reviewed Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] Lrp1 A2mr Mus musculus (Mouse) 4545 aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; beta-amyloid clearance [GO:0097242]; cardiac septum development [GO:0003279]; cholesterol metabolic process [GO:0008203]; coronary vasculature development [GO:0060976]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of lipid transport [GO:0032370]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of phospholipase A2 activity [GO:0032429] GO:0003279; GO:0005509; GO:0005730; GO:0005737; GO:0005765; GO:0005887; GO:0005905; GO:0005925; GO:0006898; GO:0008203; GO:0010875; GO:0014912; GO:0016020; GO:0030178; GO:0032370; GO:0032374; GO:0032403; GO:0032429; GO:0032956; GO:0034185; GO:0035909; GO:0043235; GO:0043277; GO:0044822; GO:0048471; GO:0060976; GO:0097242; GO:2000587 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q91ZX7 CHOYP_LRP1.5.5 m.54869 sp LRP1_MOUSE 37.464 4204 2257 126 184 4198 488 4508 0 2516 LRP1_MOUSE reviewed Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] Lrp1 A2mr Mus musculus (Mouse) 4545 aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; beta-amyloid clearance [GO:0097242]; cardiac septum development [GO:0003279]; cholesterol metabolic process [GO:0008203]; coronary vasculature development [GO:0060976]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of lipid transport [GO:0032370]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of phospholipase A2 activity [GO:0032429] GO:0003279; GO:0005509; GO:0005730; GO:0005737; GO:0005765; GO:0005887; GO:0005905; GO:0005925; GO:0006898; GO:0008203; GO:0010875; GO:0014912; GO:0016020; GO:0030178; GO:0032370; GO:0032374; GO:0032403; GO:0032429; GO:0032956; GO:0034185; GO:0035909; GO:0043235; GO:0043277; GO:0044822; GO:0048471; GO:0060976; GO:0097242; GO:2000587 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q92005 CHOYP_EF1A.2.4 m.50858 sp EF1A_DANRE 84.532 459 71 0 1 459 1 459 0 813 EF1A_DANRE reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Danio rerio (Zebrafish) (Brachydanio rerio) 462 0 GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737 0 0 0 PF03144;PF03143; Q92005 CHOYP_EF1A.3.4 m.63414 sp EF1A_DANRE 80.8 375 71 1 4 378 89 462 0 624 EF1A_DANRE reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Danio rerio (Zebrafish) (Brachydanio rerio) 462 0 GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737 0 0 0 PF03144;PF03143; Q92005 CHOYP_EF1A.4.4 m.65745 sp EF1A_DANRE 81.385 462 86 0 1 462 1 462 0 772 EF1A_DANRE reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Danio rerio (Zebrafish) (Brachydanio rerio) 462 0 GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737 0 0 0 PF03144;PF03143; Q92005 CHOYP_EF1A2.1.3 m.30022 sp EF1A_DANRE 82.505 463 76 3 6 467 4 462 0 786 EF1A_DANRE reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Danio rerio (Zebrafish) (Brachydanio rerio) 462 0 GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737 0 0 0 PF03144;PF03143; Q92072 CHOYP_DNMT1.1.1 m.54990 sp DNMT1_CHICK 56.973 1513 570 22 52 1515 30 1510 0 1684 DNMT1_CHICK reviewed DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (DNA methyltransferase GgaI) (DNA MTase GgaI) (M.GgaI) (MCMT) DNMT1 AIM DNMT Gallus gallus (Chicken) 1537 "positive regulation of methylation-dependent chromatin silencing [GO:0090309]; Ras protein signal transduction [GO:0007265]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003886; GO:0005634; GO:0006351; GO:0007265; GO:0008270; GO:0090309; GO:1990841 0 0 0 PF01426;PF06464;PF00145;PF12047;PF02008; Q921G7 CHOYP_ETFD.1.1 m.6881 sp ETFD_MOUSE 74.787 587 144 3 35 619 32 616 0 936 ETFD_MOUSE reviewed "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase)" Etfdh Mus musculus (Mouse) 616 electron transport chain [GO:0022900]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; response to oxidative stress [GO:0006979] GO:0004174; GO:0005739; GO:0005743; GO:0006979; GO:0009055; GO:0016020; GO:0016491; GO:0017133; GO:0022900; GO:0031305; GO:0031966; GO:0033539; GO:0043783; GO:0046872; GO:0048038; GO:0048039; GO:0051539 0 0 0 PF05187; Q921G8 CHOYP_GCP2.1.1 m.23103 sp GCP2_MOUSE 54.258 916 403 9 1 911 1 905 0 1009 GCP2_MOUSE reviewed Gamma-tubulin complex component 2 (GCP-2) Tubgcp2 Gcp2 Mus musculus (Mouse) 905 centrosome duplication [GO:0051298]; cytoplasmic microtubule organization [GO:0031122]; interphase microtubule nucleation by interphase microtubule organizing center [GO:0051415]; meiotic nuclear division [GO:0007126]; mitotic spindle assembly [GO:0090307] GO:0000922; GO:0000923; GO:0005200; GO:0005654; GO:0005813; GO:0005874; GO:0007126; GO:0008275; GO:0016020; GO:0031122; GO:0043015; GO:0051298; GO:0051415; GO:0090307 0 0 0 PF04130; Q921L8 CHOYP_BRAFLDRAFT_246892.1.1 m.55865 sp GLT11_MOUSE 52.783 521 226 9 75 591 98 602 0 546 GLT11_MOUSE reviewed Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) Galnt11 Mus musculus (Mouse) 608 cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; protein O-linked glycosylation via threonine [GO:0018243]; regulation of Notch signaling pathway [GO:0008593] GO:0000139; GO:0004653; GO:0005112; GO:0007220; GO:0007368; GO:0008593; GO:0016021; GO:0018243; GO:0030246; GO:0046872; GO:0060271; GO:0061314 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q922J9 CHOYP_RN45S.3.5 m.38637 sp FACR1_MOUSE 55.469 512 228 0 12 523 3 514 0 636 FACR1_MOUSE reviewed Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2) Far1 Mlstd2 Mus musculus (Mouse) 515 ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] GO:0005777; GO:0005778; GO:0008611; GO:0010025; GO:0016021; GO:0035336; GO:0046474; GO:0050062; GO:0080019 0 0 cd09071; PF07993;PF03015; Q922K7 CHOYP_LOC100207336.1.1 m.6227 sp NOP2_MOUSE 58.674 513 163 7 198 681 115 607 0 608 NOP2_MOUSE reviewed Probable 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) Nop2 Nol1 Mus musculus (Mouse) 793 maturation of LSU-rRNA [GO:0000470]; rRNA base methylation [GO:0070475] GO:0000470; GO:0005730; GO:0009383; GO:0044822; GO:0070475 0 0 0 PF01189;PF17125;PF08062; Q922K7 CHOYP_LOC663261.1.1 m.21784 sp NOP2_MOUSE 57.467 529 173 8 971 1470 115 620 0 602 NOP2_MOUSE reviewed Probable 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) Nop2 Nol1 Mus musculus (Mouse) 793 maturation of LSU-rRNA [GO:0000470]; rRNA base methylation [GO:0070475] GO:0000470; GO:0005730; GO:0009383; GO:0044822; GO:0070475 0 0 0 PF01189;PF17125;PF08062; Q922R8 CHOYP_PDIA6.1.2 m.9012 sp PDIA6_MOUSE 63.027 403 139 4 3 400 43 440 0 522 PDIA6_MOUSE reviewed Protein disulfide-isomerase A6 (EC 5.3.4.1) (Thioredoxin domain-containing protein 7) Pdia6 Txndc7 Mus musculus (Mouse) 440 apoptotic cell clearance [GO:0043277]; cell redox homeostasis [GO:0045454]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005788; GO:0005793; GO:0005886; GO:0006457; GO:0030168; GO:0034663; GO:0034976; GO:0042470; GO:0043277; GO:0045454; GO:0070062; GO:0070527 0 0 0 PF00085; Q922V4 CHOYP_PLRG1.1.1 m.65600 sp PLRG1_MOUSE 65.759 514 158 8 1 497 1 513 0 689 PLRG1_MOUSE reviewed Pleiotropic regulator 1 Plrg1 Mus musculus (Mouse) 513 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein localization to nucleus [GO:0034504]" GO:0000398; GO:0000974; GO:0005634; GO:0005654; GO:0005662; GO:0005730; GO:0016607; GO:0031965; GO:0034504; GO:0071011; GO:0071013; GO:0080008; GO:1900087 0 0 0 PF00400; Q923Q2 CHOYP_RHG07.1.1 m.14019 sp STA13_MOUSE 39.947 1139 574 30 541 1646 52 1113 0 756 STA13_MOUSE reviewed StAR-related lipid transfer protein 13 (START domain-containing protein 13) (StARD13) Stard13 Mus musculus (Mouse) 1113 cell cycle [GO:0007049]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of sprouting angiogenesis [GO:1903671]; signal transduction [GO:0007165] GO:0005096; GO:0005811; GO:0007049; GO:0007165; GO:0008289; GO:0031966; GO:0043542; GO:0090051; GO:0097498; GO:1903671 0 0 0 PF00620;PF07647;PF01852; Q924I2 CHOYP_LOC100879964.1.1 m.1780 sp M4K3_RAT 56.229 891 353 13 4 876 2 873 0 969 M4K3_RAT reviewed Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) Map4k3 Rattus norvegicus (Rat) 873 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; response to UV [GO:0009411] GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0006468; GO:0008349; GO:0009411; GO:0035556 0 0 0 PF00780;PF00069; Q924N4 CHOYP_DWIL_GK15715.1.1 m.52399 sp S12A6_MOUSE 52.699 1019 412 17 31 1010 97 1084 0 1067 S12A6_MOUSE reviewed Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) Slc12a6 Kcc3 Mus musculus (Mouse) 1150 cellular hypotonic salinity response [GO:0071477]; chemical synaptic transmission [GO:0007268]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0007268; GO:0015379; GO:0016323; GO:0022820; GO:0030424; GO:0071477 0 0 0 PF00324;PF03522; Q92508 CHOYP_LOC100372622.1.2 m.768 sp PIEZ1_HUMAN 31.769 1832 995 40 45 1674 42 1820 0 845 PIEZ1_HUMAN reviewed Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) PIEZO1 FAM38A KIAA0233 Homo sapiens (Human) 2521 cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625] GO:0005261; GO:0005783; GO:0005789; GO:0005886; GO:0006812; GO:0008381; GO:0016021; GO:0031258; GO:0033116; GO:0033625; GO:0033634 0 0 0 PF15917;PF12166; Q92508 CHOYP_LOC100372622.2.2 m.23726 sp PIEZ1_HUMAN 31.567 1793 973 40 13 1617 94 1820 0 830 PIEZ1_HUMAN reviewed Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) PIEZO1 FAM38A KIAA0233 Homo sapiens (Human) 2521 cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625] GO:0005261; GO:0005783; GO:0005789; GO:0005886; GO:0006812; GO:0008381; GO:0016021; GO:0031258; GO:0033116; GO:0033625; GO:0033634 0 0 0 PF15917;PF12166; Q92508 CHOYP_LOC100747115.1.1 m.42239 sp PIEZ1_HUMAN 31.442 1851 1016 39 45 1714 42 1820 0 847 PIEZ1_HUMAN reviewed Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A) PIEZO1 FAM38A KIAA0233 Homo sapiens (Human) 2521 cation transport [GO:0006812]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625] GO:0005261; GO:0005783; GO:0005789; GO:0005886; GO:0006812; GO:0008381; GO:0016021; GO:0031258; GO:0033116; GO:0033625; GO:0033634 0 0 0 PF15917;PF12166; Q92538 CHOYP_LOC579332.1.1 m.41750 sp GBF1_HUMAN 56.31 1783 677 31 8 1758 6 1718 0 1835 GBF1_HUMAN reviewed Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 KIAA0248 Homo sapiens (Human) 1859 "cell activation involved in immune response [GO:0002263]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; viral process [GO:0016032]" GO:0000139; GO:0002263; GO:0005085; GO:0005086; GO:0005547; GO:0005739; GO:0005777; GO:0005788; GO:0005793; GO:0005794; GO:0005795; GO:0005801; GO:0005802; GO:0005811; GO:0005829; GO:0006888; GO:0006890; GO:0006892; GO:0006895; GO:0007030; GO:0007346; GO:0015031; GO:0016020; GO:0016032; GO:0030593; GO:0031252; GO:0032012; GO:0034067; GO:0042147; GO:0048205; GO:0061162; GO:0070973; GO:0080025; GO:0090166; GO:0097111; GO:1903409; GO:1903420; GO:2000008 0 0 0 PF01369;PF12783; Q92545 CHOYP_BRAFLDRAFT_73285.1.2 m.4668 sp TM131_HUMAN 38.923 1151 664 14 31 1165 52 1179 0 812 TM131_HUMAN reviewed Transmembrane protein 131 (Protein RW1) TMEM131 KIAA0257 RW1 Homo sapiens (Human) 1883 0 GO:0016020; GO:0016021 0 0 0 PF12371; Q92545 CHOYP_BRAFLDRAFT_73285.2.2 m.12824 sp TM131_HUMAN 38.923 1151 664 14 65 1199 52 1179 0 811 TM131_HUMAN reviewed Transmembrane protein 131 (Protein RW1) TMEM131 KIAA0257 RW1 Homo sapiens (Human) 1883 0 GO:0016020; GO:0016021 0 0 0 PF12371; Q925U4 CHOYP_EDEM1.1.1 m.12175 sp EDEM1_MOUSE 62 550 192 4 28 565 107 651 0 714 EDEM1_MOUSE reviewed ER degradation-enhancing alpha-mannosidase-like protein 1 Edem1 Edem Mus musculus (Mouse) 652 "endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; glycoprotein ERAD pathway [GO:0097466]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; N-glycan processing [GO:0006491]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; trimming of terminal mannose on C branch [GO:0036510]" GO:0001948; GO:0004571; GO:0005509; GO:0005783; GO:0006491; GO:0030176; GO:0030433; GO:0030968; GO:0036510; GO:0044322; GO:0051787; GO:0097466; GO:1904154; GO:1904382 0 0 0 PF01532; Q92614 CHOYP_MYO18.1.1 m.3952 sp MY18A_HUMAN 46.329 1798 886 23 200 1956 192 1951 0 1507 MY18A_HUMAN reviewed Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) MYO18A KIAA0216 MYSPDZ Homo sapiens (Human) 2054 actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714] GO:0000139; GO:0003677; GO:0005524; GO:0005654; GO:0005793; GO:0005794; GO:0005802; GO:0006259; GO:0007030; GO:0016020; GO:0016459; GO:0016477; GO:0031032; GO:0042641; GO:0043066; GO:0043531; GO:0044822; GO:0048194; GO:0050714; GO:0051015; GO:0090161; GO:0090164 0 0 0 PF00063;PF01576;PF00595; Q92621 CHOYP_NUP205.1.1 m.54932 sp NU205_HUMAN 43.508 2064 1071 32 7 2031 2 2009 0 1640 NU205_HUMAN reviewed Nuclear pore complex protein Nup205 (205 kDa nucleoporin) (Nucleoporin Nup205) NUP205 C7orf14 KIAA0225 Homo sapiens (Human) 2012 "gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; nuclear pore complex assembly [GO:0051292]; nucleocytoplasmic transport [GO:0006913]; protein import into nucleus, docking [GO:0000059]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083]" GO:0000059; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0006406; GO:0006409; GO:0006913; GO:0007077; GO:0010827; GO:0016020; GO:0016032; GO:0016925; GO:0017056; GO:0019083; GO:0031047; GO:0031965; GO:0034399; GO:0044611; GO:0051292; GO:0075733; GO:1900034 0 0 0 PF11894; Q92626 CHOYP_PXDN.5.5 m.59444 sp PXDN_HUMAN 41.658 941 478 16 7 883 13 946 0 691 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q92630 CHOYP_EF1A.4.4 m.65743 sp DYRK2_HUMAN 67.87 554 154 9 37 570 52 601 0 761 DYRK2_HUMAN reviewed Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) DYRK2 Homo sapiens (Human) 601 cellular response to DNA damage stimulus [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of NFAT protein import into nucleus [GO:0051534]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; smoothened signaling pathway [GO:0007224] GO:0000151; GO:0000287; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0006974; GO:0007224; GO:0030145; GO:0030529; GO:0042771; GO:0043130; GO:0045725; GO:0051534; GO:1901796 0 0 0 PF00069; Q92636 CHOYP_BRAFLDRAFT_100614.1.1 m.31700 sp FAN_HUMAN 44.022 920 477 16 11 915 18 914 0 769 FAN_HUMAN reviewed Protein FAN (Factor associated with neutral sphingomyelinase activation) (Factor associated with N-SMase activation) NSMAF FAN Homo sapiens (Human) 917 ceramide metabolic process [GO:0006672]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ceramide biosynthetic process [GO:2000304]; signal transduction [GO:0007165] GO:0005057; GO:0005543; GO:0005737; GO:0005829; GO:0006672; GO:0007165; GO:0012505; GO:0016230; GO:0019898; GO:0043065; GO:2000304 0 0 cd06071; PF02138;PF02893;PF00400; Q92793 CHOYP_EP300.1.1 m.57408 sp CBP_HUMAN 49.458 831 329 12 135 896 1069 1877 0 813 CBP_HUMAN reviewed CREB-binding protein (EC 2.3.1.48) CREBBP CBP Homo sapiens (Human) 2442 "beta-catenin-TCF complex assembly [GO:1904837]; cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular lipid metabolic process [GO:0044255]; cellular response to UV [GO:0034644]; embryonic digit morphogenesis [GO:0042733]; histone acetylation [GO:0016573]; homeostatic process [GO:0042592]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; N-terminal peptidyl-lysine acetylation [GO:0018076]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of type I interferon production [GO:0032481]; protein acetylation [GO:0006473]; protein complex assembly [GO:0006461]; regulation of apoptotic process [GO:0042981]; regulation of cellular response to heat [GO:1900034]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]" GO:0000122; GO:0000123; GO:0000790; GO:0000987; GO:0001078; GO:0001085; GO:0001102; GO:0001105; GO:0001191; GO:0001666; GO:0002039; GO:0002223; GO:0003682; GO:0003684; GO:0003700; GO:0003713; GO:0004402; GO:0004871; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006355; GO:0006367; GO:0006461; GO:0006473; GO:0007165; GO:0007219; GO:0008134; GO:0008270; GO:0008283; GO:0008589; GO:0016032; GO:0016407; GO:0016573; GO:0016604; GO:0018076; GO:0032481; GO:0034212; GO:0034644; GO:0042592; GO:0042733; GO:0042981; GO:0043426; GO:0044255; GO:0045893; GO:0048511; GO:0060355; GO:0061418; GO:0070555; GO:0098609; GO:1900034; GO:1900087; GO:1901224; GO:1904837 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q92797 CHOYP_SYMPK.1.1 m.1791 sp SYMPK_HUMAN 53.072 1123 491 15 5 1106 10 1117 0 1172 SYMPK_HUMAN reviewed Symplekin SYMPK SPK Homo sapiens (Human) 1274 cell adhesion [GO:0007155]; mRNA polyadenylation [GO:0006378]; positive regulation of protein dephosphorylation [GO:0035307] GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0005923; GO:0006378; GO:0007155; GO:0035307 0 0 0 PF11935;PF12295; Q92824 CHOYP_AFURIN2.1.1 m.59865 sp PCSK5_HUMAN 44.581 895 440 21 97 957 34 906 0 706 PCSK5_HUMAN reviewed Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) PCSK5 PC5 PC6 Homo sapiens (Human) 1860 anterior/posterior pattern specification [GO:0009952]; cardiac septum development [GO:0003279]; cell-cell signaling [GO:0007267]; coronary vasculature development [GO:0060976]; cytokine biosynthetic process [GO:0042089]; determination of left/right symmetry [GO:0007368]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; heart development [GO:0007507]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; nerve growth factor processing [GO:0032455]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058] GO:0001822; GO:0002001; GO:0003279; GO:0004252; GO:0005615; GO:0005794; GO:0005796; GO:0006465; GO:0007267; GO:0007368; GO:0007507; GO:0007566; GO:0008233; GO:0009952; GO:0016021; GO:0016485; GO:0016486; GO:0019058; GO:0030141; GO:0030323; GO:0032455; GO:0035108; GO:0042089; GO:0042277; GO:0043043; GO:0048566; GO:0048706; GO:0060976 0 0 0 PF14843;PF01483;PF00082;PF16470; Q92831 CHOYP_KAT2B.1.1 m.8613 sp KAT2B_HUMAN 63.097 775 268 3 53 825 74 832 0 1031 KAT2B_HUMAN reviewed Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) KAT2B PCAF Homo sapiens (Human) 832 "cell cycle arrest [GO:0007050]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to parathyroid hormone stimulus [GO:0071374]; chromatin remodeling [GO:0006338]; histone H3 acetylation [GO:0043966]; histone H3-K9 acetylation [GO:0043970]; internal peptidyl-lysine acetylation [GO:0018393]; memory [GO:0007613]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; Notch signaling pathway [GO:0007219]; N-terminal peptidyl-lysine acetylation [GO:0018076]; peptidyl-lysine acetylation [GO:0018394]; positive regulation of chromatin binding [GO:0035563]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [GO:0035948]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of vasodilation [GO:0045909]; protein acetylation [GO:0006473]; regulation of protein ADP-ribosylation [GO:0010835]; rhythmic process [GO:0048511]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]" GO:0000125; GO:0000776; GO:0000790; GO:0000977; GO:0003682; GO:0003712; GO:0003713; GO:0004402; GO:0004468; GO:0004861; GO:0005634; GO:0005654; GO:0005671; GO:0005829; GO:0006338; GO:0006367; GO:0006473; GO:0007050; GO:0007219; GO:0007613; GO:0008134; GO:0008285; GO:0010835; GO:0010976; GO:0016032; GO:0016407; GO:0018076; GO:0018393; GO:0018394; GO:0019901; GO:0031672; GO:0031674; GO:0032403; GO:0032869; GO:0034599; GO:0035563; GO:0035948; GO:0042641; GO:0042826; GO:0043966; GO:0043970; GO:0045736; GO:0045815; GO:0045909; GO:0045944; GO:0048511; GO:0071374; GO:0071442; GO:2000617 0 0 0 PF00583;PF00439;PF06466; Q92841 CHOYP_LOC100376610.1.3 m.12022 sp DDX17_HUMAN 64.567 508 155 4 1157 1639 113 620 0 697 DDX17_HUMAN reviewed Probable ATP-dependent RNA helicase DDX17 (EC 3.6.4.13) (DEAD box protein 17) (DEAD box protein p72) (RNA-dependent helicase p72) DDX17 Homo sapiens (Human) 729 "positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of skeletal muscle cell differentiation [GO:2001014]; RNA processing [GO:0006396]; RNA secondary structure unwinding [GO:0010501]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0003723; GO:0003724; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006396; GO:0008186; GO:0010501; GO:0016020; GO:0030331; GO:0033148; GO:0044822; GO:0045944; GO:2001014 0 0 0 PF00270;PF00271; Q92947 CHOYP_LOC580832.1.1 m.66146 sp GCDH_HUMAN 75.743 404 96 1 34 437 35 436 0 672 GCDH_HUMAN reviewed "Glutaryl-CoA dehydrogenase, mitochondrial (GCD) (EC 1.3.8.6)" GCDH Homo sapiens (Human) 438 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty-acyl-CoA biosynthetic process [GO:0046949]; lipid homeostasis [GO:0055088]; lysine catabolic process [GO:0006554]; tryptophan metabolic process [GO:0006568] GO:0000062; GO:0004361; GO:0005739; GO:0005759; GO:0006554; GO:0006568; GO:0009055; GO:0033539; GO:0046949; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Amino-acid metabolism; lysine degradation.; PATHWAY: Amino-acid metabolism; tryptophan metabolism. 0 0 PF00441;PF02770;PF02771; Q92973 CHOYP_TNPO1.1.1 m.8874 sp TNPO1_HUMAN 80.179 893 173 3 45 933 6 898 0 1454 TNPO1_HUMAN reviewed Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP) TNPO1 KPNB2 MIP1 TRN Homo sapiens (Human) 898 "NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus, docking [GO:0000059]; protein import into nucleus, translocation [GO:0000060]; regulation of mRNA stability [GO:0043488]; ribosomal protein import into nucleus [GO:0006610]; viral process [GO:0016032]" GO:0000059; GO:0000060; GO:0005634; GO:0005737; GO:0005829; GO:0006607; GO:0006610; GO:0008139; GO:0008565; GO:0016032; GO:0031965; GO:0034399; GO:0043488; GO:0044822; GO:0070062; GO:0072372 0 0 0 PF03810; Q93008 CHOYP_BRAFLDRAFT_275724.1.1 m.54178 sp USP9X_HUMAN 64.452 2574 836 27 1 2510 1 2559 0 3365 USP9X_HUMAN reviewed "Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)" USP9X DFFRX FAM USP9 Homo sapiens (Human) 2570 axon extension [GO:0048675]; BMP signaling pathway [GO:0030509]; cell division [GO:0051301]; cellular protein metabolic process [GO:0044267]; chromosome segregation [GO:0007059]; female gamete generation [GO:0007292]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron migration [GO:0001764]; protein deubiquitination [GO:0016579]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000122; GO:0001764; GO:0004197; GO:0004843; GO:0005737; GO:0005829; GO:0006511; GO:0007059; GO:0007067; GO:0007179; GO:0007292; GO:0008234; GO:0016020; GO:0016579; GO:0030426; GO:0030509; GO:0044267; GO:0048675; GO:0051301; GO:0070410 0 0 0 PF00443; Q93009 CHOYP_LOC100749463.1.1 m.6770 sp UBP7_HUMAN 62.732 1076 381 10 39 1109 42 1102 0 1432 UBP7_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) USP7 HAUSP Homo sapiens (Human) 1102 maintenance of DNA methylation [GO:0010216]; multicellular organism development [GO:0007275]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of telomere capping [GO:1904353]; transcription-coupled nucleotide-excision repair [GO:0006283]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032] GO:0002039; GO:0004197; GO:0004843; GO:0005634; GO:0005654; GO:0005829; GO:0006283; GO:0006511; GO:0007275; GO:0008022; GO:0008134; GO:0010216; GO:0016032; GO:0016579; GO:0016604; GO:0016605; GO:0031625; GO:0032088; GO:0050821; GO:0051090; GO:1904353 0 0 0 PF00917;PF00443;PF14533;PF12436; Q93034 CHOYP_LOC100371275.1.1 m.46896 sp CUL5_HUMAN 75.964 778 183 3 33 809 6 780 0 1241 CUL5_HUMAN reviewed Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1) CUL5 VACM1 Homo sapiens (Human) 780 cell cycle arrest [GO:0007050]; cell proliferation [GO:0008283]; ERBB2 signaling pathway [GO:0038128]; G1/S transition of mitotic cell cycle [GO:0000082]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of cell proliferation [GO:0008285]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; viral process [GO:0016032] GO:0000082; GO:0004842; GO:0004872; GO:0005262; GO:0005829; GO:0007050; GO:0008283; GO:0008285; GO:0016032; GO:0031466; GO:0031625; GO:0038128; GO:0042787; GO:0097193 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00888;PF10557; Q93099 CHOYP_BRAFLDRAFT_73486.1.1 m.16417 sp HGD_HUMAN 70.642 436 121 4 8 437 1 435 0 656 HGD_HUMAN reviewed "Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase)" HGD HGO Homo sapiens (Human) 445 L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] GO:0004411; GO:0005829; GO:0006559; GO:0006572; GO:0046872; GO:0070062 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. 0 0 PF04209; Q93129 CHOYP_ACT.4.27 m.14034 sp ACTC_BRABE 90.642 374 35 0 3 376 2 375 0 727 ACTC_BRABE reviewed "Actin, cytoplasmic (BbCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma belcheri (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q93129 CHOYP_ACTC.2.6 m.15315 sp ACTC_BRABE 89.031 392 26 2 1 392 1 375 0 735 ACTC_BRABE reviewed "Actin, cytoplasmic (BbCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma belcheri (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q93131 CHOYP_ACT.17.27 m.45020 sp ACTC_BRAFL 83.498 303 9 2 25 327 114 375 0 510 ACTC_BRAFL reviewed "Actin, cytoplasmic (BfCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma floridae (Florida lancelet) (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q93131 CHOYP_ACT.25.27 m.63942 sp ACTC_BRAFL 88.474 321 10 1 1 321 82 375 0 588 ACTC_BRAFL reviewed "Actin, cytoplasmic (BfCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma floridae (Florida lancelet) (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q94887 CHOYP_NRX4.1.1 m.8135 sp NRX4_DROME 37.366 1215 685 27 1 1188 119 1284 0 768 NRX4_DROME reviewed Neurexin-4 (Neurexin IV) Nrx-IV Nrx CG6827 Drosophila melanogaster (Fruit fly) 1284 "axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; cell-cell junction organization [GO:0045216]; dorsal closure [GO:0007391]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of cell polarity [GO:0007163]; heart process [GO:0003015]; nerve maturation [GO:0021682]; presynaptic membrane assembly [GO:0097105]; protein localization [GO:0008104]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; synaptic target recognition [GO:0008039]; synaptic vesicle docking [GO:0016081]; synaptic vesicle targeting [GO:0016080]; terminal button organization [GO:0072553]" GO:0003015; GO:0005886; GO:0005887; GO:0005918; GO:0005919; GO:0007163; GO:0007391; GO:0008039; GO:0008104; GO:0008366; GO:0016080; GO:0016081; GO:0019991; GO:0021682; GO:0035151; GO:0045216; GO:0048786; GO:0060857; GO:0061343; GO:0072553; GO:0097105 0 0 0 PF00008;PF00754;PF02210; Q95334 CHOYP_PHUM_PHUM512710.1.2 m.56673 sp AMPE_PIG 38.965 947 540 18 35 958 9 940 0 652 AMPE_PIG reviewed Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (CD antigen CD249) ENPEP Sus scrofa (Pig) 942 angiotensin maturation [GO:0002003]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081] GO:0002003; GO:0003081; GO:0005737; GO:0005886; GO:0006508; GO:0008217; GO:0008270; GO:0008283; GO:0016021; GO:0016477; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; Q95K79 CHOYP_ALKB8.1.2 m.27789 sp ALKB8_MACFA 45.868 726 295 12 2 694 3 663 0 592 ALKB8_MACFA reviewed Alkylated DNA repair protein alkB homolog 8 (EC 1.14.11.-) (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.-) (EC 2.1.1.229) ALKBH8 QtrA-10552 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 664 cellular response to DNA damage stimulus [GO:0006974]; oxidation-reduction process [GO:0055114]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] GO:0000049; GO:0000166; GO:0002098; GO:0005506; GO:0005634; GO:0005829; GO:0006974; GO:0008270; GO:0016300; GO:0016706; GO:0030488; GO:0055114 0 0 0 PF13532;PF09004;PF08241;PF00076; Q95M18 CHOYP_LOC100215003.1.1 m.22606 sp ENPL_BOVIN 65.478 533 177 3 2 533 229 755 0 686 ENPL_BOVIN reviewed Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) HSP90B1 GRP94 TRA1 Bos taurus (Bovine) 804 "actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; negative regulation of apoptotic process [GO:0043066]; protein folding [GO:0006457]; regulation of phosphoprotein phosphatase activity [GO:0043666]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]" GO:0001666; GO:0003723; GO:0005524; GO:0005634; GO:0005783; GO:0005788; GO:0005789; GO:0005829; GO:0005886; GO:0005925; GO:0006457; GO:0030433; GO:0030496; GO:0030970; GO:0031012; GO:0031247; GO:0034663; GO:0042470; GO:0043066; GO:0043666; GO:0046790; GO:0048471; GO:0050750; GO:0070062; GO:0071318 0 0 0 PF02518;PF00183; Q95YJ5 CHOYP_TXND3.1.4 m.3505 sp TXND3_CIOIN 51.832 573 235 7 2 550 65 620 0 561 TXND3_CIOIN reviewed Thioredoxin domain-containing protein 3 homolog (Dynein intermediate chain 3) CiIC3 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) 653 cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; multicellular organism development [GO:0007275]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228] GO:0004550; GO:0005622; GO:0006183; GO:0006228; GO:0006241; GO:0007275; GO:0007283; GO:0030154; GO:0045454; GO:1902176 0 0 0 PF00334;PF00085; Q95ZJ1 CHOYP_CBR-GLY-5.1.1 m.26441 sp GALT5_CAEEL 61.217 526 187 8 131 641 97 620 0 662 GALT5_CAEEL reviewed Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans 626 protein O-linked glycosylation via threonine [GO:0018243] GO:0000139; GO:0004653; GO:0016021; GO:0018243; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q95ZJ1 CHOYP_SMP_005500.1.1 m.34627 sp GALT5_CAEEL 53.939 495 222 6 101 591 106 598 0 564 GALT5_CAEEL reviewed Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans 626 protein O-linked glycosylation via threonine [GO:0018243] GO:0000139; GO:0004653; GO:0016021; GO:0018243; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q964D9 CHOYP_ACTC.5.6 m.58242 sp ACTC_PLATR 83.777 376 57 1 1 372 1 376 0 659 ACTC_PLATR reviewed "Actin, cytoplasmic" 0 Planorbella trivolvis (Marsh rams-horn) (Helisoma trivolvis) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q969H0 CHOYP_FBXW7.1.1 m.56730 sp FBXW7_HUMAN 74.776 559 126 3 203 751 154 707 0 864 FBXW7_HUMAN reviewed F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) 707 cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; lipid homeostasis [GO:0055088]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1903146]; regulation of protein localization [GO:0032880]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; vasculature development [GO:0001944]; viral process [GO:0016032] GO:0000209; GO:0001944; GO:0004842; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006974; GO:0007062; GO:0010868; GO:0010883; GO:0016032; GO:0016567; GO:0019005; GO:0030332; GO:0030674; GO:0031146; GO:0031398; GO:0031625; GO:0032876; GO:0032880; GO:0034644; GO:0042802; GO:0043234; GO:0045741; GO:0045746; GO:0050816; GO:0050821; GO:0051443; GO:0055088; GO:0070374; GO:0097027; GO:1901800; GO:1902806; GO:1903146; GO:1903378; GO:1903955; GO:1990452; GO:2000060; GO:2000346; GO:2000639 0 0 0 PF12937;PF00400; Q96AY4 CHOYP_TTC28.1.1 m.51607 sp TTC28_HUMAN 56.835 1946 785 14 105 2016 58 1982 0 2228 TTC28_HUMAN reviewed Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) 2481 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of mitotic cell cycle [GO:0007346] GO:0000922; GO:0005737; GO:0005813; GO:0007067; GO:0007346; GO:0030496; GO:0051301 0 0 0 PF12770;PF13176;PF13181; Q96BY7 CHOYP_ATG2A.1.1 m.57169 sp ATG2B_HUMAN 36.509 2194 1126 57 1 2047 1 2074 0 1249 ATG2B_HUMAN reviewed Autophagy-related protein 2 homolog B ATG2B C14orf103 Homo sapiens (Human) 2078 autophagosome assembly [GO:0000045]; mitophagy [GO:0000422]; nucleophagy [GO:0044804] GO:0000045; GO:0000407; GO:0000422; GO:0005811; GO:0019898; GO:0034045; GO:0044804 0 0 0 PF13329;PF09333;PF12624; Q96CN5 CHOYP_LOC100376045.1.1 m.30010 sp LRC45_HUMAN 44.096 669 366 4 1 668 1 662 0 555 LRC45_HUMAN reviewed Leucine-rich repeat-containing protein 45 LRRC45 Homo sapiens (Human) 670 0 GO:0005654; GO:0005737; GO:0005813; GO:0005886 0 0 0 PF13516; Q96D46 CHOYP_LOC100373569.1.1 m.280 sp NMD3_HUMAN 58.683 501 201 6 1 499 1 497 0 632 NMD3_HUMAN reviewed 60S ribosomal export protein NMD3 (hNMD3) NMD3 CGI-07 Homo sapiens (Human) 503 protein transport [GO:0015031]; ribosomal large subunit export from nucleus [GO:0000055] GO:0000055; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0015031; GO:0016020; GO:0030674; GO:0043023; GO:0044822 0 0 0 PF04981; Q96DI7 CHOYP_LOC100373287.1.1 m.36226 sp SNR40_HUMAN 69.034 352 100 2 4 346 6 357 0 537 SNR40_HUMAN reviewed U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) SNRNP40 PRP8BP SFP38 WDR57 Homo sapiens (Human) 357 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0005654; GO:0005682; GO:0005732; GO:0005737; GO:0006396; GO:0008380; GO:0044822; GO:0071011; GO:0071013 0 0 0 PF00400; Q96EZ8 CHOYP_MCRS1.1.1 m.12227 sp MCRS1_HUMAN 63.615 426 145 3 73 497 45 461 0 560 MCRS1_HUMAN reviewed Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) MCRS1 INO80Q MSP58 Homo sapiens (Human) 462 "cellular protein modification process [GO:0006464]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0002151; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005844; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0006464; GO:0008266; GO:0010521; GO:0015629; GO:0030054; GO:0030425; GO:0031011; GO:0034046; GO:0043204; GO:0043981; GO:0043982; GO:0043984; GO:0051974; GO:0071339; GO:1904357; GO:1904751 0 0 0 PF00498;PF13325; Q96G03 CHOYP_PGM2.1.1 m.65095 sp PGM2_HUMAN 54.785 606 265 4 2 599 7 611 0 683 PGM2_HUMAN reviewed Phosphoglucomutase-2 (PGM 2) (EC 5.4.2.2) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphopentomutase) (EC 5.4.2.7) PGM2 MSTP006 Homo sapiens (Human) 612 deoxyribose phosphate catabolic process [GO:0046386]; galactose catabolic process [GO:0019388]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; pentose-phosphate shunt [GO:0006098] GO:0000287; GO:0004614; GO:0005829; GO:0005978; GO:0005980; GO:0006006; GO:0006098; GO:0008973; GO:0019388; GO:0046386; GO:0070062 PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2. 0 0 PF02878;PF02879;PF02880;PF00408; Q96GQ7 CHOYP_VP13D.2.3 m.58593 sp DDX27_HUMAN 55.364 755 303 8 7 731 33 783 0 772 DDX27_HUMAN reviewed Probable ATP-dependent RNA helicase DDX27 (EC 3.6.4.13) (DEAD box protein 27) DDX27 cPERP-F RHLP HSPC259 PP3241 Homo sapiens (Human) 796 RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364] GO:0004004; GO:0005524; GO:0005694; GO:0005730; GO:0006364; GO:0010501; GO:0044822 0 0 0 PF00270;PF00271; Q96HN2 CHOYP_LOC100121788.1.1 m.28436 sp SAHH3_HUMAN 81.057 454 84 1 53 506 160 611 0 808 SAHH3_HUMAN reviewed Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) AHCYL2 KIAA0828 Homo sapiens (Human) 611 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] GO:0005783; GO:0005829; GO:0006730; GO:0016787; GO:0033353; GO:0043005 PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. 0 cd00401; PF05221;PF00670; Q96HN2 CHOYP_SAHH3.1.2 m.44564 sp SAHH3_HUMAN 75.246 509 117 4 38 543 109 611 0 814 SAHH3_HUMAN reviewed Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) AHCYL2 KIAA0828 Homo sapiens (Human) 611 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] GO:0005783; GO:0005829; GO:0006730; GO:0016787; GO:0033353; GO:0043005 PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. 0 cd00401; PF05221;PF00670; Q96HN2 CHOYP_SAHH3.2.2 m.51221 sp SAHH3_HUMAN 81.057 454 84 1 72 525 160 611 0 811 SAHH3_HUMAN reviewed Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2) AHCYL2 KIAA0828 Homo sapiens (Human) 611 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353] GO:0005783; GO:0005829; GO:0006730; GO:0016787; GO:0033353; GO:0043005 PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. 0 cd00401; PF05221;PF00670; Q96HW7 CHOYP_BRAFLDRAFT_283451.1.1 m.41825 sp INT4_HUMAN 42.002 969 520 14 1 933 1 963 0 710 INT4_HUMAN reviewed Integrator complex subunit 4 (Int4) INTS4 MSTP093 Homo sapiens (Human) 963 snRNA processing [GO:0016180]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0005654; GO:0016180; GO:0032039; GO:0042795 0 0 0 PF12765; Q96IG2 CHOYP_ISCW_ISCW014887.1.1 m.27250 sp FXL20_HUMAN 62.471 429 159 1 12 440 10 436 0 551 FXL20_HUMAN reviewed F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) FBXL20 FBL2 Homo sapiens (Human) 436 behavioral fear response [GO:0001662] GO:0001662; GO:0005737 0 0 0 PF12937;PF13516; Q96J94 CHOYP_BRAFLDRAFT_126411.1.1 m.49664 sp PIWL1_HUMAN 50.473 846 403 10 32 873 28 861 0 905 PIWL1_HUMAN reviewed Piwi-like protein 1 PIWIL1 HIWI Homo sapiens (Human) 861 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; regulation of translation [GO:0006417]; spermatid development [GO:0007286] GO:0003727; GO:0003729; GO:0005634; GO:0005737; GO:0005844; GO:0005845; GO:0006417; GO:0007275; GO:0007286; GO:0031047; GO:0033391; GO:0034584; GO:0034587; GO:0043186; GO:0051321; GO:0097433 0 0 0 PF08699;PF05831;PF02170;PF02171; Q96JB2 CHOYP_COG3.1.1 m.35921 sp COG3_HUMAN 50.66 833 378 8 21 841 16 827 0 832 COG3_HUMAN reviewed Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) COG3 SEC34 Homo sapiens (Human) 828 "ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0000301; GO:0005654; GO:0005737; GO:0005794; GO:0005801; GO:0005886; GO:0006486; GO:0006886; GO:0006888; GO:0006890; GO:0006891; GO:0007030; GO:0008565; GO:0017119; GO:0032580; GO:0032588; GO:0033365; GO:0050821 0 0 0 PF04136; Q96JC1 CHOYP_LOC100378848.1.1 m.29949 sp VPS39_HUMAN 55.017 887 374 12 1 869 1 880 0 948 VPS39_HUMAN reviewed Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) VPS39 KIAA0770 TLP VAM6 Homo sapiens (Human) 886 "autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; retrograde transport, endosome to plasma membrane [GO:1990126]; vacuole fusion [GO:0097576]" GO:0005765; GO:0006886; GO:0006914; GO:0008333; GO:0030123; GO:0030897; GO:0031902; GO:0034058; GO:0097576; GO:1902774; GO:1990126 0 0 0 PF00780;PF10366;PF10367; Q96JG6 CHOYP_CC132.1.1 m.34774 sp VPS50_HUMAN 54.892 971 401 13 6 948 3 964 0 1063 VPS50_HUMAN reviewed Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) VPS50 CCDC132 KIAA1861 Homo sapiens (Human) 964 endocytic recycling [GO:0032456]; protein transport [GO:0015031] GO:0000149; GO:0015031; GO:0016020; GO:0032456; GO:0055037; GO:0070062; GO:1990745 0 0 0 PF10474;PF10475; Q96JJ3 CHOYP_ELMO1.1.1 m.59285 sp ELMO2_HUMAN 43.568 723 379 12 21 725 6 717 0 618 ELMO2_HUMAN reviewed Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A) ELMO2 CED12A KIAA1834 Homo sapiens (Human) 720 apoptotic process [GO:0006915]; cell-cell adhesion [GO:0098609]; cell chemotaxis [GO:0060326]; cytoskeleton organization [GO:0007010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0005737; GO:0005829; GO:0006915; GO:0007010; GO:0016020; GO:0030971; GO:0038096; GO:0048010; GO:0060326; GO:0098609 0 0 0 PF11841;PF04727;PF16457; Q96KG9 CHOYP_BRAFLDRAFT_101148.1.1 m.24200 sp SCYL1_HUMAN 51.334 787 327 14 1 762 1 756 0 770 SCYL1_HUMAN reviewed N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase) SCYL1 CVAK90 GKLP NTKL TAPK TEIF TRAP HT019 Homo sapiens (Human) 808 "regulation of transcription, DNA-templated [GO:0006355]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005793; GO:0005794; GO:0005801; GO:0005815; GO:0005913; GO:0006351; GO:0006355; GO:0006890; GO:0016020; GO:0030126; GO:0098641 0 0 0 PF00069; Q96KP1 CHOYP_EXOC2.1.3 m.360 sp EXOC2_HUMAN 41.969 965 482 20 7 951 8 914 0 690 EXOC2_HUMAN reviewed Exocyst complex component 2 (Exocyst complex component Sec5) EXOC2 SEC5 SEC5L1 Homo sapiens (Human) 924 exocyst assembly [GO:0001927]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535] GO:0000145; GO:0001927; GO:0005829; GO:0005886; GO:0006893; GO:0015031; GO:0016020; GO:0017160; GO:0019901; GO:0043231; GO:2000535 0 0 0 PF01833; Q96KP1 CHOYP_EXOC2.3.3 m.23467 sp EXOC2_HUMAN 42.524 943 486 18 7 929 8 914 0 698 EXOC2_HUMAN reviewed Exocyst complex component 2 (Exocyst complex component Sec5) EXOC2 SEC5 SEC5L1 Homo sapiens (Human) 924 exocyst assembly [GO:0001927]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535] GO:0000145; GO:0001927; GO:0005829; GO:0005886; GO:0006893; GO:0015031; GO:0016020; GO:0017160; GO:0019901; GO:0043231; GO:2000535 0 0 0 PF01833; Q96KP4 CHOYP_CNDP2.1.4 m.11722 sp CNDP2_HUMAN 70.45 467 138 0 46 512 7 473 0 707 CNDP2_HUMAN reviewed Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Carnosine dipeptidase II) (Epididymis secretory protein Li 13) (Glutamate carboxypeptidase-like protein 1) (Peptidase A) CNDP2 CN2 CPGL HEL-S-13 PEPA Homo sapiens (Human) 475 glutathione biosynthetic process [GO:0006750]; peptide catabolic process [GO:0043171]; sulfur amino acid metabolic process [GO:0000096] GO:0000096; GO:0004180; GO:0005654; GO:0005737; GO:0005829; GO:0006750; GO:0008270; GO:0043171; GO:0070062; GO:0070573; GO:0102008 0 0 cd05676; PF07687;PF01546; Q96KR1 CHOYP_LOC100371229.1.2 m.1173 sp ZFR_HUMAN 52.769 993 337 20 44 932 106 1070 0 847 ZFR_HUMAN reviewed Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) ZFR Homo sapiens (Human) 1074 multicellular organism development [GO:0007275] GO:0003677; GO:0005654; GO:0005694; GO:0005737; GO:0007275; GO:0008270; GO:0044822 0 0 0 PF07528; Q96KR1 CHOYP_ZFR.1.1 m.57469 sp ZFR_HUMAN 51.707 996 364 19 51 960 106 1070 0 845 ZFR_HUMAN reviewed Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) ZFR Homo sapiens (Human) 1074 multicellular organism development [GO:0007275] GO:0003677; GO:0005654; GO:0005694; GO:0005737; GO:0007275; GO:0008270; GO:0044822 0 0 0 PF07528; Q96L92 CHOYP_LOC100904232.1.1 m.38777 sp SNX27_HUMAN 59.213 483 193 2 188 669 41 520 0 615 SNX27_HUMAN reviewed Sorting nexin-27 SNX27 KIAA0488 My014 Homo sapiens (Human) 541 "endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; response to drug [GO:0042493]; retrograde transport, endosome to plasma membrane [GO:1990126]; signal transduction [GO:0007165]" GO:0001770; GO:0001772; GO:0005654; GO:0005737; GO:0005769; GO:0005829; GO:0006886; GO:0007165; GO:0008333; GO:0016197; GO:0031901; GO:0032266; GO:0042493; GO:1990126 0 0 0 PF00595;PF00787;PF00788; Q96L93 CHOYP_KI16B.1.3 m.42636 sp KI16B_HUMAN 56.899 703 267 10 6 689 70 755 0 749 KI16B_HUMAN reviewed Kinesin-like protein KIF16B (Sorting nexin-23) KIF16B C20orf23 KIAA1590 SNX23 Homo sapiens (Human) 1317 cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; microtubule-based movement [GO:0007018]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919] GO:0001704; GO:0001919; GO:0005524; GO:0005547; GO:0005768; GO:0005769; GO:0005829; GO:0005871; GO:0005874; GO:0006895; GO:0007018; GO:0007173; GO:0007492; GO:0008543; GO:0008574; GO:0030705; GO:0031901; GO:0032266; GO:0032801; GO:0043325; GO:0045022; GO:0080025 0 0 0 PF00498;PF00225;PF00787; Q96L93 CHOYP_KI16B.3.3 m.56753 sp KI16B_HUMAN 47.688 757 316 16 1 755 1 679 0 655 KI16B_HUMAN reviewed Kinesin-like protein KIF16B (Sorting nexin-23) KIF16B C20orf23 KIAA1590 SNX23 Homo sapiens (Human) 1317 cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; microtubule-based movement [GO:0007018]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919] GO:0001704; GO:0001919; GO:0005524; GO:0005547; GO:0005768; GO:0005769; GO:0005829; GO:0005871; GO:0005874; GO:0006895; GO:0007018; GO:0007173; GO:0007492; GO:0008543; GO:0008574; GO:0030705; GO:0031901; GO:0032266; GO:0032801; GO:0043325; GO:0045022; GO:0080025 0 0 0 PF00498;PF00225;PF00787; Q96M32 CHOYP_LOC100369935.1.1 m.40124 sp KAD7_HUMAN 51.768 707 326 5 10 702 16 721 0 695 KAD7_HUMAN reviewed Adenylate kinase 7 (AK 7) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 7) AK7 Homo sapiens (Human) 723 cell projection organization [GO:0030030]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142] GO:0004017; GO:0004127; GO:0004550; GO:0005524; GO:0005829; GO:0006165; GO:0009142; GO:0015949; GO:0019206; GO:0030030 0 0 cd01428; PF05186; Q96MT7 CHOYP_WDR52.1.1 m.21751 sp CFA44_HUMAN 50.851 881 411 10 276 1142 105 977 0 887 CFA44_HUMAN reviewed Cilia- and flagella-associated protein 44 (WD repeat-containing protein 52) CFAP44 WDR52 Homo sapiens (Human) 982 0 GO:0042995 0 0 0 PF00400; Q96MW5 CHOYP_COG8.1.1 m.10907 sp COG8_HUMAN 55.21 547 227 5 2 531 20 565 0 632 COG8_HUMAN reviewed Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8) COG8 Homo sapiens (Human) 612 ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031] GO:0000139; GO:0006888; GO:0006891; GO:0015031; GO:0016020; GO:0017119; GO:0032588 0 0 0 PF04124; Q96N23 CHOYP_BRAFLDRAFT_125670.1.1 m.9555 sp CFA54_HUMAN 34.299 2003 1145 41 19 2004 59 1907 0 1068 CFA54_HUMAN reviewed Cilia- and flagella-associated protein 54 CFAP54 C12orf55 C12orf63 Homo sapiens (Human) 3096 cell differentiation [GO:0030154]; cilium assembly [GO:0042384]; cilium movement involved in cell motility [GO:0060294]; spermatogenesis [GO:0007283] GO:0005737; GO:0005930; GO:0007283; GO:0030154; GO:0042384; GO:0060294 0 0 0 PF14858; Q96N67 CHOYP_DOCK7.1.3 m.1197 sp DOCK7_HUMAN 50.744 2217 896 36 29 2152 3 2116 0 2067 DOCK7_HUMAN reviewed Dedicator of cytokinesis protein 7 DOCK7 KIAA1771 Homo sapiens (Human) 2140 activation of GTPase activity [GO:0090630]; axonogenesis [GO:0007409]; establishment of neuroblast polarity [GO:0045200]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of neurogenesis [GO:0050767]; small GTPase mediated signal transduction [GO:0007264] GO:0000226; GO:0005085; GO:0005622; GO:0005925; GO:0007264; GO:0007409; GO:0022027; GO:0030424; GO:0030426; GO:0031175; GO:0033138; GO:0043005; GO:0045178; GO:0045200; GO:0048365; GO:0050767; GO:0090630; GO:1904754 0 0 0 PF06920;PF14429;PF11878; Q96N67 CHOYP_DOCK7.3.3 m.47354 sp DOCK7_HUMAN 52.246 2159 893 34 33 2098 3 2116 0 2104 DOCK7_HUMAN reviewed Dedicator of cytokinesis protein 7 DOCK7 KIAA1771 Homo sapiens (Human) 2140 activation of GTPase activity [GO:0090630]; axonogenesis [GO:0007409]; establishment of neuroblast polarity [GO:0045200]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of neurogenesis [GO:0050767]; small GTPase mediated signal transduction [GO:0007264] GO:0000226; GO:0005085; GO:0005622; GO:0005925; GO:0007264; GO:0007409; GO:0022027; GO:0030424; GO:0030426; GO:0031175; GO:0033138; GO:0043005; GO:0045178; GO:0045200; GO:0048365; GO:0050767; GO:0090630; GO:1904754 0 0 0 PF06920;PF14429;PF11878; Q96NN9 CHOYP_LOC100150876.1.1 m.61100 sp AIFM3_HUMAN 46.024 591 301 3 227 812 9 586 0 574 AIFM3_HUMAN reviewed Apoptosis-inducing factor 3 (EC 1.-.-.-) (Apoptosis-inducing factor-like protein) AIFM3 AIFL Homo sapiens (Human) 605 cell redox homeostasis [GO:0045454]; execution phase of apoptosis [GO:0097194] GO:0005739; GO:0005743; GO:0005783; GO:0016491; GO:0045454; GO:0046872; GO:0050660; GO:0051537; GO:0097194 0 0 0 PF07992;PF14759;PF00355; Q96P47 CHOYP_CEG1A.5.6 m.41676 sp AGAP3_HUMAN 44.262 915 328 20 6 830 22 844 0 701 AGAP3_HUMAN reviewed "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP-3) (CRAM-associated GTPase) (CRAG) (Centaurin-gamma-3) (Cnt-g3) (MR1-interacting protein) (MRIP-1)" AGAP3 CENTG3 Homo sapiens (Human) 875 small GTPase mediated signal transduction [GO:0007264] GO:0005096; GO:0005525; GO:0005737; GO:0007264; GO:0016020; GO:0046872 0 0 0 PF12796;PF01412;PF00071; Q96P53 CHOYP_BRAFLDRAFT_70886.1.1 m.53762 sp WDFY2_HUMAN 56.965 402 170 1 13 414 1 399 0 516 WDFY2_HUMAN reviewed WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22) WDFY2 WDF2 ZFYVE22 Homo sapiens (Human) 400 positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein phosphorylation [GO:0001934] GO:0001934; GO:0005769; GO:0031982; GO:0045600; GO:0046872 0 0 0 PF01363;PF00400; Q96PB1 CHOYP_ISCW_ISCW021640.1.1 m.51589 sp CASD1_HUMAN 45.74 763 373 9 46 801 45 773 0 704 CASD1_HUMAN reviewed CAS1 domain-containing protein 1 CASD1 C7orf12 Nbla04196 Homo sapiens (Human) 797 0 GO:0016021 0 0 0 PF07779; Q96PH1 CHOYP_TRIADDRAFT_29444.1.2 m.9373 sp NOX5_HUMAN 48.306 797 343 10 217 984 9 765 0 723 NOX5_HUMAN reviewed NADPH oxidase 5 (EC 1.6.3.-) NOX5 Homo sapiens (Human) 765 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; cytokine secretion [GO:0050663]; cytokinesis [GO:0000910]; endothelial cell proliferation [GO:0001935]; oxidation-reduction process [GO:0055114]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of fusion of sperm to egg plasma membrane [GO:0043012]; regulation of proton transport [GO:0010155]; response to reactive oxygen species [GO:0000302]; superoxide anion generation [GO:0042554] GO:0000302; GO:0000910; GO:0001525; GO:0001935; GO:0005509; GO:0005783; GO:0005789; GO:0006915; GO:0008283; GO:0010155; GO:0015252; GO:0016021; GO:0016175; GO:0020037; GO:0042554; GO:0043012; GO:0050660; GO:0050661; GO:0050663; GO:0055114; GO:2000379 0 0 0 PF13202;PF13405;PF08022;PF01794;PF08030; Q96PH1 CHOYP_TRIADDRAFT_29444.2.2 m.24555 sp NOX5_HUMAN 43.79 781 374 12 52 804 22 765 0 627 NOX5_HUMAN reviewed NADPH oxidase 5 (EC 1.6.3.-) NOX5 Homo sapiens (Human) 765 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; cytokine secretion [GO:0050663]; cytokinesis [GO:0000910]; endothelial cell proliferation [GO:0001935]; oxidation-reduction process [GO:0055114]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of fusion of sperm to egg plasma membrane [GO:0043012]; regulation of proton transport [GO:0010155]; response to reactive oxygen species [GO:0000302]; superoxide anion generation [GO:0042554] GO:0000302; GO:0000910; GO:0001525; GO:0001935; GO:0005509; GO:0005783; GO:0005789; GO:0006915; GO:0008283; GO:0010155; GO:0015252; GO:0016021; GO:0016175; GO:0020037; GO:0042554; GO:0043012; GO:0050660; GO:0050661; GO:0050663; GO:0055114; GO:2000379 0 0 0 PF13202;PF13405;PF08022;PF01794;PF08030; Q96PQ7 CHOYP_KLHL5.1.1 m.40365 sp KLHL5_HUMAN 70.37 567 167 1 96 662 188 753 0 879 KLHL5_HUMAN reviewed Kelch-like protein 5 KLHL5 Homo sapiens (Human) 755 protein ubiquitination [GO:0016567] GO:0005737; GO:0005856; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q96Q42 CHOYP_ALS2.1.3 m.33568 sp ALS2_HUMAN 34.564 1733 1000 36 3 1679 2 1656 0 926 ALS2_HUMAN reviewed Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein) ALS2 ALS2CR6 KIAA1563 Homo sapiens (Human) 1657 "axonogenesis [GO:0007409]; behavioral fear response [GO:0001662]; cell death [GO:0008219]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; in utero embryonic development [GO:0001701]; locomotory behavior [GO:0007626]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of Rac protein signal transduction [GO:0035022]; protein localization [GO:0008104]; Rac protein signal transduction [GO:0016601]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; regulation of Rho protein signal transduction [GO:0035023]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]; vesicle organization [GO:0016050]" GO:0001662; GO:0001701; GO:0001726; GO:0001881; GO:0005087; GO:0005769; GO:0005813; GO:0005829; GO:0006979; GO:0007032; GO:0007409; GO:0007528; GO:0007626; GO:0008104; GO:0008219; GO:0014069; GO:0016020; GO:0016050; GO:0016197; GO:0016601; GO:0017112; GO:0017137; GO:0030027; GO:0030424; GO:0030425; GO:0030426; GO:0030676; GO:0031982; GO:0035022; GO:0035023; GO:0035249; GO:0042803; GO:0043025; GO:0043197; GO:0043234; GO:0043539; GO:0043547; GO:0045860; GO:0048812; GO:0051036 0 0 0 PF02493;PF00415;PF00621;PF02204; Q96QE2 CHOYP_MYCT.2.2 m.45577 sp MYCT_HUMAN 51.391 611 257 7 41 613 6 614 0 629 MYCT_HUMAN reviewed Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) 648 glucose import [GO:0046323]; hexose transmembrane transport [GO:0035428] GO:0005351; GO:0005355; GO:0005366; GO:0005886; GO:0005887; GO:0035428; GO:0046323 0 0 cd06174; PF00083; Q96QU8 CHOYP_XPO6.1.1 m.15288 sp XPO6_HUMAN 55.325 1155 474 9 1 1145 1 1123 0 1311 XPO6_HUMAN reviewed Exportin-6 (Exp6) (Ran-binding protein 20) XPO6 KIAA0370 RANBP20 Homo sapiens (Human) 1125 protein export from nucleus [GO:0006611] GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006611; GO:0008565 0 0 0 PF03810;PF08389; Q96RK4 CHOYP_BBS4.1.1 m.50943 sp BBS4_HUMAN 65.76 441 144 1 55 495 20 453 0 610 BBS4_HUMAN reviewed Bardet-Biedl syndrome 4 protein BBS4 Homo sapiens (Human) 519 adult behavior [GO:0030534]; brain morphogenesis [GO:0048854]; centrosome organization [GO:0051297]; cerebral cortex development [GO:0021987]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; dendrite development [GO:0016358]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; fat pad development [GO:0060613]; heart looping [GO:0001947]; hippocampus development [GO:0021766]; intracellular transport [GO:0046907]; maintenance of protein location in nucleus [GO:0051457]; melanosome transport [GO:0032402]; microtubule anchoring at centrosome [GO:0034454]; microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of gene expression [GO:0010629]; negative regulation of GTPase activity [GO:0034260]; negative regulation of systemic arterial blood pressure [GO:0003085]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; nonmotile primary cilium assembly [GO:0035058]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of cilium assembly [GO:0045724]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to centrosome [GO:0071539]; protein localization to cilium [GO:0061512]; protein localization to organelle [GO:0033365]; protein localization to photoreceptor outer segment [GO:1903546]; protein transport [GO:0015031]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of cytokinesis [GO:0032465]; regulation of lipid metabolic process [GO:0019216]; regulation of nonmotile primary cilium assembly [GO:1902855]; regulation of stress fiber assembly [GO:0051492]; retina homeostasis [GO:0001895]; retinal rod cell development [GO:0046548]; sensory perception of smell [GO:0007608]; sensory processing [GO:0050893]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual perception [GO:0007601] GO:0000226; GO:0000242; GO:0000281; GO:0001103; GO:0001750; GO:0001764; GO:0001843; GO:0001895; GO:0001917; GO:0001947; GO:0003085; GO:0003777; GO:0005634; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0007286; GO:0007601; GO:0007608; GO:0010629; GO:0015031; GO:0016358; GO:0019216; GO:0021591; GO:0021756; GO:0021766; GO:0021987; GO:0030534; GO:0030837; GO:0031513; GO:0031514; GO:0032391; GO:0032402; GO:0032465; GO:0033365; GO:0034260; GO:0034451; GO:0034452; GO:0034454; GO:0034464; GO:0035058; GO:0035176; GO:0035845; GO:0035869; GO:0036064; GO:0038108; GO:0040018; GO:0042384; GO:0043014; GO:0045444; GO:0045494; GO:0045724; GO:0046548; GO:0046907; GO:0048487; GO:0048854; GO:0050893; GO:0051297; GO:0051457; GO:0051492; GO:0060170; GO:0060271; GO:0060296; GO:0060324; GO:0060613; GO:0061512; GO:0071539; GO:1902855; GO:1903546 0 0 0 PF13414;PF13181; Q96RQ3 CHOYP_MCCA.1.1 m.18170 sp MCCA_HUMAN 61.638 696 266 1 15 709 17 712 0 886 MCCA_HUMAN reviewed "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)" MCCC1 MCCA Homo sapiens (Human) 725 biotin metabolic process [GO:0006768]; branched-chain amino acid catabolic process [GO:0009083]; leucine catabolic process [GO:0006552]; protein heterooligomerization [GO:0051291] GO:0002169; GO:0004075; GO:0004485; GO:0005524; GO:0005739; GO:0005743; GO:0005759; GO:0005829; GO:0006552; GO:0006768; GO:0009083; GO:0009374; GO:0046872; GO:0051291 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. 0 0 PF02785;PF00289;PF00364;PF02786; Q96RT8 CHOYP_GCP5.1.1 m.15877 sp GCP5_HUMAN 39.363 1067 542 21 21 1042 16 1022 0 694 GCP5_HUMAN reviewed Gamma-tubulin complex component 5 (GCP-5) TUBGCP5 GCP5 KIAA1899 Homo sapiens (Human) 1024 centrosome duplication [GO:0051298]; cytoplasmic microtubule organization [GO:0031122]; interphase microtubule nucleation by interphase microtubule organizing center [GO:0051415]; meiotic nuclear division [GO:0007126]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307] GO:0000922; GO:0000923; GO:0005200; GO:0005737; GO:0005813; GO:0005829; GO:0005874; GO:0007020; GO:0007126; GO:0008017; GO:0008274; GO:0031122; GO:0043015; GO:0051298; GO:0051415; GO:0090307 0 0 0 PF04130; Q96RV3 CHOYP_PCX1.1.1 m.55309 sp PCX1_HUMAN 59.657 1108 430 7 937 2039 968 2063 0 1446 PCX1_HUMAN reviewed Pecanex-like protein 1 (Pecanex homolog protein 1) PCNX1 KIAA0805 KIAA0995 PCNX PCNXL1 Homo sapiens (Human) 2341 0 GO:0016021 0 0 0 PF05041; Q96RY7 CHOYP_IFT140.1.1 m.61053 sp IF140_HUMAN 50.975 1487 691 16 1 1475 1 1461 0 1549 IF140_HUMAN reviewed Intraflagellar transport protein 140 homolog (WD and tetratricopeptide repeats protein 2) IFT140 KIAA0590 WDTC2 Homo sapiens (Human) 1462 cilium assembly [GO:0042384]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; intraciliary retrograde transport [GO:0035721]; limb morphogenesis [GO:0035108]; neural tube patterning [GO:0021532]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to cilium [GO:0061512]; regulation of cilium assembly [GO:1902017]; regulation of smoothened signaling pathway [GO:0008589]; renal system development [GO:0072001]; retina development in camera-type eye [GO:0060041]; skeletal system morphogenesis [GO:0048705] GO:0001750; GO:0005737; GO:0005813; GO:0005930; GO:0007368; GO:0007507; GO:0008589; GO:0021532; GO:0030991; GO:0032391; GO:0035108; GO:0035721; GO:0035845; GO:0036064; GO:0042384; GO:0048705; GO:0060041; GO:0061512; GO:0072001; GO:0072372; GO:0097542; GO:1902017 0 0 0 0 Q96SY0 CHOYP_VWA9.1.1 m.14382 sp VWA9_HUMAN 52.794 519 233 6 1 511 1 515 0 566 VWA9_HUMAN reviewed von Willebrand factor A domain-containing protein 9 VWA9 C15orf44 Homo sapiens (Human) 518 snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0005654; GO:0042795 0 0 0 PF13519; Q98931 CHOYP_LRP8.1.1 m.12055 sp LRP8_CHICK 40.839 906 470 25 29 916 24 881 0 637 LRP8_CHICK reviewed Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) (Protein LR8B) LRP8 LR8B Gallus gallus (Chicken) 917 endocytosis [GO:0006897]; ventral spinal cord development [GO:0021517] GO:0005509; GO:0006897; GO:0016021; GO:0021517 0 0 0 PF00057;PF00058; Q98SP7 CHOYP_LOC100375650.1.1 m.51555 sp BBS2_DANRE 61.622 740 253 6 1 736 1 713 0 959 BBS2_DANRE reviewed Bardet-Biedl syndrome 2 protein homolog bbs2 Danio rerio (Zebrafish) (Brachydanio rerio) 715 cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; gastrulation [GO:0007369]; intracellular transport [GO:0046907]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; nonmotile primary cilium assembly [GO:0035058]; pigment granule aggregation in cell center [GO:0051877]; protein localization to ciliary membrane [GO:1903441] GO:0005737; GO:0007368; GO:0007369; GO:0016020; GO:0031514; GO:0032402; GO:0034464; GO:0035058; GO:0036064; GO:0042384; GO:0046907; GO:0051877; GO:0060170; GO:0060271; GO:0070121; GO:1903441 0 0 0 PF14782;PF14783;PF14781; Q99259 CHOYP_DCE1.1.1 m.26578 sp DCE1_HUMAN 50.851 529 249 6 36 554 61 588 0 547 DCE1_HUMAN reviewed Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform) GAD1 GAD GAD67 Homo sapiens (Human) 594 chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; glutamate catabolic process [GO:0006538]; glutamate decarboxylation to succinate [GO:0006540]; neurotransmitter biosynthetic process [GO:0042136]; neurotransmitter secretion [GO:0007269]; protein-pyridoxal-5-phosphate linkage [GO:0018352]; response to drug [GO:0042493] GO:0004351; GO:0005622; GO:0005886; GO:0006538; GO:0006540; GO:0007268; GO:0007269; GO:0009449; GO:0012506; GO:0016595; GO:0018352; GO:0030170; GO:0042136; GO:0042493; GO:0048786; GO:0061202 0 0 0 PF00282; Q99323 CHOYP_LOC100649130.1.1 m.58207 sp MYSN_DROME 62.679 1956 691 5 13 1931 56 2009 0 2357 MYSN_DROME reviewed "Myosin heavy chain, non-muscle (Myosin II) (Non-muscle MHC) (Zipper protein)" zip CG15792 Drosophila melanogaster (Fruit fly) 2057 "anterior midgut development [GO:0007496]; border follicle cell migration [GO:0007298]; cellular response to mechanical stimulus [GO:0071260]; cuticle pattern formation [GO:0035017]; dorsal closure [GO:0007391]; dorsal closure, amnioserosa morphology change [GO:0046664]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; establishment of neuroblast polarity [GO:0045200]; establishment of planar polarity [GO:0001736]; head involution [GO:0008258]; imaginal disc-derived wing hair organization [GO:0035317]; left/right axis specification [GO:0070986]; maintenance of protein location in cell [GO:0032507]; Malpighian tubule morphogenesis [GO:0007443]; mitotic cytokinesis [GO:0000281]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; myosin II filament assembly [GO:0031036]; neurogenesis [GO:0022008]; ovarian follicle cell migration [GO:0007297]; protein oligomerization [GO:0051259]; regulation of cell cycle [GO:0051726]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; sarcomere organization [GO:0045214]; spiracle morphogenesis, open tracheal system [GO:0035277]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0003774; GO:0005524; GO:0005829; GO:0005856; GO:0005938; GO:0006936; GO:0007297; GO:0007298; GO:0007391; GO:0007395; GO:0007435; GO:0007443; GO:0007496; GO:0008258; GO:0016459; GO:0016460; GO:0016461; GO:0022008; GO:0030018; GO:0030239; GO:0031036; GO:0031252; GO:0032027; GO:0032154; GO:0032507; GO:0035017; GO:0035159; GO:0035277; GO:0035317; GO:0042060; GO:0042623; GO:0044291; GO:0045179; GO:0045200; GO:0045214; GO:0046663; GO:0046664; GO:0051259; GO:0051726; GO:0070986; GO:0071260; GO:1901739 0 0 0 PF00612;PF00063;PF02736;PF01576; Q99447 CHOYP_LOC551931.1.1 m.9934 sp PCY2_HUMAN 68.333 360 112 1 29 386 12 371 0 535 PCY2_HUMAN reviewed Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) PCYT2 Homo sapiens (Human) 389 phosphatidylethanolamine biosynthetic process [GO:0006646]; phospholipid biosynthetic process [GO:0008654] GO:0004306; GO:0005789; GO:0006646; GO:0008654 PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3. 0 0 PF01467; Q99460 CHOYP_PSMD1.1.1 m.21682 sp PSMD1_HUMAN 71.058 964 243 8 5 962 2 935 0 1339 PSMD1_HUMAN reviewed 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) PSMD1 Homo sapiens (Human) 953 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0005634; GO:0005654; GO:0005829; GO:0005838; GO:0006521; GO:0008540; GO:0016020; GO:0022624; GO:0030234; GO:0031145; GO:0033209; GO:0034515; GO:0038061; GO:0038095; GO:0043161; GO:0043488; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070062; GO:0090090; GO:0090263 0 0 0 PF01851; Q99570 CHOYP_PI3R4.1.1 m.14910 sp PI3R4_HUMAN 52.089 1388 607 23 1 1360 1 1358 0 1400 PI3R4_HUMAN reviewed Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) PIK3R4 VPS15 Homo sapiens (Human) 1358 cellular response to glucose starvation [GO:0042149]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; pexophagy [GO:0030242]; phosphatidylinositol biosynthetic process [GO:0006661]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; protein phosphorylation [GO:0006468]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; toll-like receptor 9 signaling pathway [GO:0034162] GO:0004672; GO:0004674; GO:0005524; GO:0005643; GO:0005770; GO:0005776; GO:0005829; GO:0005930; GO:0006468; GO:0006623; GO:0006661; GO:0016020; GO:0016236; GO:0016303; GO:0030242; GO:0030670; GO:0032465; GO:0032801; GO:0034162; GO:0034271; GO:0034272; GO:0035032; GO:0042149; GO:0043552; GO:0045324; GO:0071561 0 0 0 PF00069;PF00400; Q99615 CHOYP_DNJC7.1.1 m.8987 sp DNJC7_HUMAN 61.983 484 178 4 40 520 14 494 0 550 DNJC7_HUMAN reviewed DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) DNAJC7 TPR2 TTC2 Homo sapiens (Human) 494 chaperone cofactor-dependent protein refolding [GO:0070389]; protein folding [GO:0006457]; regulation of cellular response to heat [GO:1900034] GO:0001671; GO:0005654; GO:0005737; GO:0005829; GO:0005856; GO:0006457; GO:0016020; GO:0031072; GO:0070062; GO:0070389; GO:1900034 0 0 cd06257; PF00226;PF13414;PF13181; Q99758 CHOYP_ABCA3.1.6 m.1056 sp ABCA3_HUMAN 38.347 1742 949 32 8 1669 6 1702 0 1150 ABCA3_HUMAN reviewed ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) 1704 cellular protein metabolic process [GO:0044267]; lipid transport [GO:0006869]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005319; GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0044267; GO:0051384; GO:0055085; GO:0097208; GO:0097232; GO:0097233 0 0 0 PF00005; Q99758 CHOYP_ABCA3.2.6 m.4295 sp ABCA3_HUMAN 38.191 1736 963 33 8 1671 6 1703 0 1141 ABCA3_HUMAN reviewed ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) 1704 cellular protein metabolic process [GO:0044267]; lipid transport [GO:0006869]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005319; GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0044267; GO:0051384; GO:0055085; GO:0097208; GO:0097232; GO:0097233 0 0 0 PF00005; Q99758 CHOYP_ABCA3.4.6 m.50918 sp ABCA3_HUMAN 38.06 1093 569 28 3 1021 24 1082 0 673 ABCA3_HUMAN reviewed ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) 1704 cellular protein metabolic process [GO:0044267]; lipid transport [GO:0006869]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005319; GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0044267; GO:0051384; GO:0055085; GO:0097208; GO:0097232; GO:0097233 0 0 0 PF00005; Q99758 CHOYP_ABCA3.5.6 m.54787 sp ABCA3_HUMAN 42.89 1744 901 27 2 1709 17 1701 0 1382 ABCA3_HUMAN reviewed ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) 1704 cellular protein metabolic process [GO:0044267]; lipid transport [GO:0006869]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005319; GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0044267; GO:0051384; GO:0055085; GO:0097208; GO:0097232; GO:0097233 0 0 0 PF00005; Q99758 CHOYP_ABCA3.6.6 m.66374 sp ABCA3_HUMAN 37.903 1116 579 26 4 1041 2 1081 0 702 ABCA3_HUMAN reviewed ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) 1704 cellular protein metabolic process [GO:0044267]; lipid transport [GO:0006869]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005319; GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0044267; GO:0051384; GO:0055085; GO:0097208; GO:0097232; GO:0097233 0 0 0 PF00005; Q99758 CHOYP_LOC100373083.1.2 m.19986 sp ABCA3_HUMAN 39.885 1740 951 26 8 1693 6 1704 0 1235 ABCA3_HUMAN reviewed ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) 1704 cellular protein metabolic process [GO:0044267]; lipid transport [GO:0006869]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005319; GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0044267; GO:0051384; GO:0055085; GO:0097208; GO:0097232; GO:0097233 0 0 0 PF00005; Q99758 CHOYP_LOC100373083.2.2 m.26841 sp ABCA3_HUMAN 41.758 728 393 11 20 742 1003 1704 0 586 ABCA3_HUMAN reviewed ATP-binding cassette sub-family A member 3 (ABC-C transporter) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) ABCA3 ABC3 Homo sapiens (Human) 1704 cellular protein metabolic process [GO:0044267]; lipid transport [GO:0006869]; response to drug [GO:0042493]; response to glucocorticoid [GO:0051384]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005319; GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016020; GO:0016021; GO:0042493; GO:0042626; GO:0044267; GO:0051384; GO:0055085; GO:0097208; GO:0097232; GO:0097233 0 0 0 PF00005; Q99798 CHOYP_ACON.1.1 m.61060 sp ACON_HUMAN 75.754 763 184 1 192 953 17 779 0 1202 ACON_HUMAN reviewed "Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)" ACO2 Homo sapiens (Human) 780 citrate metabolic process [GO:0006101]; generation of precursor metabolites and energy [GO:0006091]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] GO:0003994; GO:0005506; GO:0005634; GO:0005739; GO:0005759; GO:0006091; GO:0006099; GO:0006101; GO:0006102; GO:0043209; GO:0051538; GO:0051539 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. 0 0 PF00330;PF00694; Q99805 CHOYP_PSMD1.1.1 m.21683 sp TM9S2_HUMAN 70.156 640 180 4 15 652 33 663 0 959 TM9S2_HUMAN reviewed Transmembrane 9 superfamily member 2 (p76) TM9SF2 Homo sapiens (Human) 663 transport [GO:0006810] GO:0005768; GO:0005887; GO:0006810; GO:0010008; GO:0070062 0 0 0 PF02990; Q99805 CHOYP_TM9S2.1.1 m.9097 sp TM9S2_HUMAN 70.156 640 180 4 15 652 33 663 0 959 TM9S2_HUMAN reviewed Transmembrane 9 superfamily member 2 (p76) TM9SF2 Homo sapiens (Human) 663 transport [GO:0006810] GO:0005768; GO:0005887; GO:0006810; GO:0010008; GO:0070062 0 0 0 PF02990; Q99835 CHOYP_SMO.1.1 m.55093 sp SMO_HUMAN 50 576 272 10 35 605 69 633 0 588 SMO_HUMAN reviewed Smoothened homolog (SMO) (Protein Gx) SMO SMOH Homo sapiens (Human) 787 anterior/posterior pattern specification [GO:0009952]; astrocyte activation [GO:0048143]; atrial septum morphogenesis [GO:0060413]; cell fate specification [GO:0001708]; cellular response to cholesterol [GO:0071397]; central nervous system neuron differentiation [GO:0021953]; cerebellar cortex morphogenesis [GO:0021696]; cerebral cortex development [GO:0021987]; dentate gyrus development [GO:0021542]; detection of cell density by contact stimulus involved in contact inhibition [GO:0060248]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; dorsal/ventral neural tube patterning [GO:0021904]; epithelial-mesenchymal cell signaling [GO:0060684]; forebrain morphogenesis [GO:0048853]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mammary gland epithelial cell differentiation [GO:0060644]; mesenchymal to epithelial transition involved in metanephric renal vesicle formation [GO:0072285]; midgut development [GO:0007494]; multicellular organism growth [GO:0035264]; myoblast migration [GO:0051451]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA binding [GO:0043392]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of gene expression [GO:0010629]; negative regulation of hair follicle development [GO:0051799]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural crest cell migration [GO:0001755]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; pancreas morphogenesis [GO:0061113]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of gene expression [GO:0010628]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of organ growth [GO:0046622]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; regulation of heart morphogenesis [GO:2000826]; regulation of stem cell population maintenance [GO:2000036]; renal system development [GO:0072001]; skeletal muscle fiber development [GO:0048741]; smoothened signaling pathway [GO:0007224]; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [GO:0021938]; smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021910]; somite development [GO:0061053]; thalamus development [GO:0021794]; type B pancreatic cell development [GO:0003323]; vasculogenesis [GO:0001570]; ventral midline determination [GO:0007371] GO:0000122; GO:0001570; GO:0001649; GO:0001701; GO:0001708; GO:0001755; GO:0001947; GO:0002052; GO:0002053; GO:0003140; GO:0003323; GO:0004930; GO:0005113; GO:0005886; GO:0007224; GO:0007228; GO:0007371; GO:0007494; GO:0008144; GO:0009952; GO:0010628; GO:0010629; GO:0016021; GO:0017147; GO:0021542; GO:0021696; GO:0021794; GO:0021904; GO:0021910; GO:0021938; GO:0021953; GO:0021987; GO:0030666; GO:0030857; GO:0031069; GO:0034504; GO:0035264; GO:0040018; GO:0042307; GO:0042475; GO:0043066; GO:0043231; GO:0043392; GO:0045880; GO:0045944; GO:0046622; GO:0048143; GO:0048741; GO:0048853; GO:0048873; GO:0050679; GO:0050821; GO:0051451; GO:0051799; GO:0060170; GO:0060248; GO:0060413; GO:0060644; GO:0060684; GO:0061053; GO:0061113; GO:0070062; GO:0070986; GO:0071397; GO:0072001; GO:0072285; GO:0072372; GO:0090190; GO:0097542; GO:2000036; GO:2000826 0 0 0 PF01534;PF01392; Q99JY0 CHOYP_SYAC.2.2 m.18501 sp ECHB_MOUSE 71.535 404 109 3 1 402 76 475 0 602 ECHB_MOUSE reviewed "Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]" Hadhb Mus musculus (Mouse) 475 fatty acid beta-oxidation [GO:0006635] GO:0003988; GO:0005739; GO:0005741; GO:0005743; GO:0005783; GO:0006635; GO:0016507; GO:0016509; GO:0042645; GO:0044822; GO:0070062 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF02803;PF00108; Q99L43 CHOYP_CDS2.1.1 m.6865 sp CDS2_MOUSE 59.333 450 168 3 27 469 1 442 0 555 CDS2_MOUSE reviewed Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) Cds2 Mus musculus (Mouse) 444 CDP-diacylglycerol biosynthetic process [GO:0016024]; glycosylation [GO:0070085]; phosphatidylglycerol biosynthetic process [GO:0006655]; phototransduction [GO:0007602] GO:0004605; GO:0005743; GO:0005783; GO:0005789; GO:0006655; GO:0007602; GO:0016020; GO:0016021; GO:0016024; GO:0070085 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. 0 0 0 Q99LC9 CHOYP_LOC101175128.1.1 m.13811 sp PEX6_MOUSE 42.785 797 416 14 335 1113 205 979 0 558 PEX6_MOUSE reviewed Peroxisome assembly factor 2 (PAF-2) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1) Pex6 Mus musculus (Mouse) 981 "peroxisome organization [GO:0007031]; protein import into peroxisome matrix, translocation [GO:0016561]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]" GO:0005524; GO:0005737; GO:0005777; GO:0005778; GO:0005829; GO:0006625; GO:0007031; GO:0008022; GO:0016561; GO:0016887; GO:0032403; GO:0042623; GO:0050821 0 0 0 PF00004; Q99LE6 CHOYP_ABCF2.1.2 m.28360 sp ABCF2_MOUSE 69.9 598 173 4 11 605 21 614 0 863 ABCF2_MOUSE reviewed ATP-binding cassette sub-family F member 2 Abcf2 Mus musculus (Mouse) 628 0 GO:0005524; GO:0005739; GO:0016020; GO:0016887 0 0 0 PF00005;PF12848; Q99LH1 CHOYP_NOG2.1.1 m.41399 sp NOG2_MOUSE 50.207 723 316 9 4 700 2 706 0 688 NOG2_MOUSE reviewed Nucleolar GTP-binding protein 2 Gnl2 Mus musculus (Mouse) 728 ribosome biogenesis [GO:0042254] GO:0003924; GO:0005525; GO:0005730; GO:0016020; GO:0042254; GO:0044822 0 0 0 PF01926;PF08153; Q99MD6 CHOYP_BRAFLDRAFT_122807.1.1 m.3729 sp TRXR3_MOUSE 62.995 581 212 3 16 593 70 650 0 738 TRXR3_MOUSE reviewed Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2) Txnrd3 Tgr Trxr3 Mus musculus (Mouse) 652 cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; glutathione metabolic process [GO:0006749]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0004791; GO:0005634; GO:0005783; GO:0006749; GO:0007275; GO:0007283; GO:0009055; GO:0015035; GO:0030154; GO:0045454; GO:0050660 0 0 0 PF00462;PF07992;PF02852; Q99MK2 CHOYP_KAT5.1.1 m.9015 sp KAT5_RAT 61.089 514 156 8 9 484 6 513 0 614 KAT5_RAT reviewed Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5) Kat5 Htatip Tip60 Tip60b Rattus norvegicus (Rat) 513 "apoptotic process [GO:0006915]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to X-ray [GO:0071481]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; histone acetylation [GO:0016573]; histone H4 acetylation [GO:0043967]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to heat [GO:0009408]; transcription, DNA-templated [GO:0006351]" GO:0000790; GO:0000812; GO:0003682; GO:0003713; GO:0004402; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006351; GO:0006915; GO:0006978; GO:0008134; GO:0009408; GO:0016573; GO:0032403; GO:0032777; GO:0035267; GO:0043234; GO:0043274; GO:0043967; GO:0045893; GO:0045944; GO:0046872; GO:0048471; GO:0070301; GO:0071481 0 0 0 PF01853;PF11717; Q99MN1 CHOYP_LOC100114247.1.1 m.30717 sp SYK_MOUSE 69.072 582 167 4 59 631 15 592 0 838 SYK_MOUSE reviewed Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) Kars Mus musculus (Mouse) 595 lysyl-tRNA aminoacylation [GO:0006430] GO:0003676; GO:0004824; GO:0005524; GO:0005737; GO:0005739; GO:0006430; GO:0015630; GO:0046872 0 0 cd00775; PF00152;PF01336; Q99MY8 CHOYP_ASH1L.1.2 m.9030 sp ASH1L_MOUSE 47.668 879 398 10 1492 2312 2064 2938 0 865 ASH1L_MOUSE reviewed Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.43) (ASH1-like protein) (Absent small and homeotic disks protein 1 homolog) Ash1l Mus musculus (Mouse) 2958 "histone H3-K36 dimethylation [GO:0097676]; histone H3-K4 methylation [GO:0051568]; interleukin-6 production [GO:0032635]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0002674; GO:0003677; GO:0003682; GO:0005654; GO:0005694; GO:0005737; GO:0005794; GO:0005923; GO:0006351; GO:0008270; GO:0032635; GO:0042800; GO:0043124; GO:0043409; GO:0045944; GO:0046975; GO:0050728; GO:0051568; GO:0070062; GO:0097676 0 0 0 PF01426;PF00439;PF00856; Q99MY8 CHOYP_ASH1L.2.2 m.57387 sp ASH1L_MOUSE 43.828 1118 528 22 1314 2353 1843 2938 0 915 ASH1L_MOUSE reviewed Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.43) (ASH1-like protein) (Absent small and homeotic disks protein 1 homolog) Ash1l Mus musculus (Mouse) 2958 "histone H3-K36 dimethylation [GO:0097676]; histone H3-K4 methylation [GO:0051568]; interleukin-6 production [GO:0032635]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0002674; GO:0003677; GO:0003682; GO:0005654; GO:0005694; GO:0005737; GO:0005794; GO:0005923; GO:0006351; GO:0008270; GO:0032635; GO:0042800; GO:0043124; GO:0043409; GO:0045944; GO:0046975; GO:0050728; GO:0051568; GO:0070062; GO:0097676 0 0 0 PF01426;PF00439;PF00856; Q99NB1 CHOYP_BRAFLDRAFT_59014.1.1 m.59709 sp ACS2L_MOUSE 61.146 646 245 4 36 676 32 676 0 834 ACS2L_MOUSE reviewed "Acetyl-coenzyme A synthetase 2-like, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase 2) (Acetyl-CoA synthetase 2) (AceCS2) (Acyl-CoA synthetase short-chain family member 1)" Acss1 Acas2 Acas2l Mus musculus (Mouse) 682 acetate biosynthetic process [GO:0019413]; acetyl-CoA biosynthetic process [GO:0006085]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; propionate biosynthetic process [GO:0019542] GO:0003987; GO:0005524; GO:0005739; GO:0005759; GO:0006085; GO:0016208; GO:0019413; GO:0019427; GO:0019542 0 0 cd05966; PF16177;PF00501;PF13193; Q99NH0 CHOYP_ANR17.1.2 m.772 sp ANR17_MOUSE 68.655 788 203 12 63 844 131 880 0 1019 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q99P84 CHOYP_FUCTA.2.4 m.17455 sp PLCE1_RAT 40.804 995 470 25 2 947 1305 2229 0 654 PLCE1_RAT reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" Plce1 Plce Rattus norvegicus (Rat) 2281 activation of MAPK activity [GO:0000187]; G-protein coupled receptor signaling pathway [GO:0007186]; lipid catabolic process [GO:0016042]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; Ras protein signal transduction [GO:0007265]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; regulation of protein kinase activity [GO:0045859]; regulation of Ras protein signal transduction [GO:0046578] GO:0000139; GO:0000187; GO:0004435; GO:0004629; GO:0004871; GO:0005085; GO:0005737; GO:0005829; GO:0005886; GO:0007186; GO:0007200; GO:0007265; GO:0008277; GO:0016042; GO:0017016; GO:0019899; GO:0045859; GO:0046578 0 0 0 PF00168;PF00388;PF00387;PF00788;PF00617; Q99PF4 CHOYP_BRAFLDRAFT_130106.1.1 m.47318 sp CAD23_MOUSE 31.567 1831 1101 59 36 1819 1426 3151 0 657 CAD23_MOUSE reviewed Cadherin-23 (Otocadherin) Cdh23 Mus musculus (Mouse) 3354 auditory receptor cell differentiation [GO:0042491]; auditory receptor cell stereocilium organization [GO:0060088]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; cell adhesion [GO:0007155]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; post-embryonic organ morphogenesis [GO:0048563]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0001917; GO:0005509; GO:0005813; GO:0005886; GO:0006816; GO:0007155; GO:0007156; GO:0007605; GO:0007626; GO:0016021; GO:0016339; GO:0032420; GO:0032426; GO:0042472; GO:0042491; GO:0045202; GO:0045494; GO:0048563; GO:0048839; GO:0050953; GO:0050957; GO:0051480; GO:0060088; GO:0060091; GO:0060122 0 0 0 PF00028; Q99PV0 CHOYP_PRP8.1.1 m.51584 sp PRP8_MOUSE 92.879 2317 164 1 44 2359 19 2335 0 4554 PRP8_MOUSE reviewed Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) Prpf8 Prp8 Mus musculus (Mouse) 2335 "cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000386; GO:0000398; GO:0005634; GO:0005682; GO:0016020; GO:0016607; GO:0017070; GO:0030619; GO:0030620; GO:0030623; GO:0044822; GO:0070530; GO:0071013; GO:0071222; GO:0071356; GO:0097157 0 0 cd13838; PF01398;PF08082;PF08083;PF08084;PF12134;PF10598;PF10597;PF10596; Q99PV3 CHOYP_MKLN1.1.1 m.34670 sp MKLN1_RAT 60.055 726 274 7 10 724 15 735 0 919 MKLN1_RAT reviewed Muskelin Mkln1 Msk Rattus norvegicus (Rat) 735 actin cytoskeleton reorganization [GO:0031532]; cell-matrix adhesion [GO:0007160]; regulation of cell shape [GO:0008360] GO:0001726; GO:0005829; GO:0005938; GO:0007160; GO:0008360; GO:0031532 0 0 0 PF01344;PF06588; Q99PW8 CHOYP_LOC100377381.1.2 m.29868 sp KIF17_MOUSE 66.808 473 141 4 1 464 1 466 0 664 KIF17_MOUSE reviewed Kinesin-like protein KIF17 (MmKIF17) Kif17 Mus musculus (Mouse) 1038 cell projection organization [GO:0030030]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; neurogenesis [GO:0022008]; protein complex localization [GO:0031503]; vesicle-mediated transport [GO:0016192] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0005929; GO:0005930; GO:0007017; GO:0007018; GO:0008574; GO:0015630; GO:0016192; GO:0022008; GO:0030030; GO:0030992; GO:0031503; GO:0032391; GO:0036064; GO:0042073; GO:1990075 0 0 0 PF00225; Q99PW8 CHOYP_LOC100377381.2.2 m.49035 sp KIF17_MOUSE 68.192 459 130 4 1 450 1 452 0 662 KIF17_MOUSE reviewed Kinesin-like protein KIF17 (MmKIF17) Kif17 Mus musculus (Mouse) 1038 cell projection organization [GO:0030030]; intraciliary transport [GO:0042073]; microtubule-based movement [GO:0007018]; microtubule-based process [GO:0007017]; neurogenesis [GO:0022008]; protein complex localization [GO:0031503]; vesicle-mediated transport [GO:0016192] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0005929; GO:0005930; GO:0007017; GO:0007018; GO:0008574; GO:0015630; GO:0016192; GO:0022008; GO:0030030; GO:0030992; GO:0031503; GO:0032391; GO:0036064; GO:0042073; GO:1990075 0 0 0 PF00225; Q9BRS2 CHOYP_BRAFLDRAFT_124526.1.1 m.25228 sp RIOK1_HUMAN 56.582 509 190 8 72 568 77 566 0 557 RIOK1_HUMAN reviewed Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (RIO kinase 1) RIOK1 Homo sapiens (Human) 568 rRNA processing [GO:0006364] GO:0004674; GO:0005524; GO:0005654; GO:0005829; GO:0006364; GO:0046872 0 0 0 0 Q9BTW9 CHOYP_TBCD.1.2 m.35202 sp TBCD_HUMAN 52.515 1173 546 4 10 1173 15 1185 0 1238 TBCD_HUMAN reviewed Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) TBCD KIAA0988 SSD1 TFCD PP1096 Homo sapiens (Human) 1192 adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of microtubule polymerization [GO:0031115]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] GO:0005096; GO:0005737; GO:0005874; GO:0005912; GO:0005923; GO:0006457; GO:0007021; GO:0007023; GO:0010812; GO:0016328; GO:0031115; GO:0034333; GO:0048487; GO:0051087; GO:0070830 0 0 0 PF12612; Q9BUQ8 CHOYP_DDX23.1.1 m.20195 sp DDX23_HUMAN 69.571 769 202 9 12 777 80 819 0 1014 DDX23_HUMAN reviewed Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) DDX23 Homo sapiens (Human) 820 "cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000354; GO:0000375; GO:0000398; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005682; GO:0005730; GO:0008380; GO:0010501; GO:0044822; GO:0070062; GO:0071013 0 0 0 PF00270;PF00271; Q9BV94 CHOYP_AAEL_AAEL005639.1.1 m.10386 sp EDEM2_HUMAN 63.713 474 172 0 35 508 35 508 0 671 EDEM2_HUMAN reviewed ER degradation-enhancing alpha-mannosidase-like protein 2 EDEM2 C20orf31 C20orf49 UNQ573/PRO1135 Homo sapiens (Human) 578 "endoplasmic reticulum mannose trimming [GO:1904380]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; glycoprotein ERAD pathway [GO:0097466]; mannose trimming involved in glycoprotein ERAD pathway [GO:1904382]; N-glycan processing [GO:0006491]; positive regulation of retrograde protein transport, ER to cytosol [GO:1904154]; trimming of terminal mannose on B branch [GO:0036509]" GO:0001948; GO:0004559; GO:0004571; GO:0005509; GO:0005783; GO:0005788; GO:0006491; GO:0016020; GO:0030433; GO:0030968; GO:0036509; GO:0044322; GO:0097466; GO:1904154; GO:1904380; GO:1904382 0 0 0 PF01532; Q9BVG8 CHOYP_LOC100375065.1.1 m.7678 sp KIFC3_HUMAN 47.005 651 326 6 263 897 130 777 0 556 KIFC3_HUMAN reviewed Kinesin-like protein KIFC3 KIFC3 Homo sapiens (Human) 833 epithelial cell-cell adhesion [GO:0090136]; Golgi organization [GO:0007030]; microtubule-based movement [GO:0007018]; visual perception [GO:0007601]; zonula adherens maintenance [GO:0045218] GO:0003777; GO:0005524; GO:0005794; GO:0005813; GO:0005871; GO:0005874; GO:0005915; GO:0007018; GO:0007030; GO:0007601; GO:0008569; GO:0016887; GO:0030659; GO:0045218; GO:0070062; GO:0090136 0 0 0 PF00225; Q9BWT3 CHOYP_PAPOG.2.2 m.38497 sp PAPOG_HUMAN 55.121 537 227 5 9 537 20 550 0 612 PAPOG_HUMAN reviewed Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) PAPOLG PAP2 PAPG Homo sapiens (Human) 736 mRNA polyadenylation [GO:0006378]; RNA polyadenylation [GO:0043631] GO:0003723; GO:0004652; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006378; GO:0016020; GO:0043631; GO:0046872 0 0 0 PF01909;PF04928;PF04926; Q9BX10 CHOYP_LOC100375058.1.1 m.58963 sp GTPB2_HUMAN 62.709 539 197 4 17 554 56 591 0 700 GTPB2_HUMAN reviewed GTP-binding protein 2 GTPBP2 Homo sapiens (Human) 602 translational elongation [GO:0006414] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0006414; GO:0043231 0 0 0 0 Q9BX70 CHOYP_BTBD2.1.1 m.59696 sp BTBD2_HUMAN 73.963 434 112 1 132 564 92 525 0 691 BTBD2_HUMAN reviewed BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) 525 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of proteolysis [GO:0030162] GO:0000932; GO:0019005; GO:0030162; GO:0031625; GO:0042787; GO:0043161 0 0 0 PF07707;PF00651;PF08005; Q9BXB4 CHOYP_BRAFLDRAFT_226345.1.1 m.55555 sp OSB11_HUMAN 48.986 690 312 11 3 666 63 738 0 644 OSB11_HUMAN reviewed Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11) OSBPL11 ORP11 OSBP12 Homo sapiens (Human) 747 fat cell differentiation [GO:0045444]; lipid transport [GO:0006869]; positive regulation of sequestering of triglyceride [GO:0010890] GO:0005794; GO:0006869; GO:0008289; GO:0010890; GO:0031902; GO:0045444 0 0 0 PF01237;PF00169; Q9BXJ9 CHOYP_NAA15.1.1 m.34959 sp NAA15_HUMAN 62.194 857 314 6 1 851 1 853 0 1076 NAA15_HUMAN reviewed "N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100)" NAA15 GA19 NARG1 NATH TBDN100 Homo sapiens (Human) 866 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of apoptotic process [GO:0043066]; N-terminal peptidyl-methionine acetylation [GO:0017196]; N-terminal protein amino acid acetylation [GO:0006474]; positive regulation of transcription, DNA-templated [GO:0045893]; protein stabilization [GO:0050821]; transcription, DNA-templated [GO:0006351]" GO:0001525; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006474; GO:0016020; GO:0017196; GO:0030154; GO:0031415; GO:0043022; GO:0043066; GO:0044822; GO:0045893; GO:0050821 0 0 0 PF12569;PF13181; Q9BXS5 CHOYP_AP1M1.1.1 m.56248 sp AP1M1_HUMAN 83.924 423 67 1 1 422 1 423 0 749 AP1M1_HUMAN reviewed AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) AP1M1 CLTNM Homo sapiens (Human) 423 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; regulation of defense response to virus by virus [GO:0050690]; vesicle-mediated transport [GO:0016192]; viral process [GO:0016032] GO:0000139; GO:0005765; GO:0005829; GO:0006886; GO:0016020; GO:0016032; GO:0016192; GO:0019886; GO:0030131; GO:0030659; GO:0030669; GO:0032438; GO:0032588; GO:0035646; GO:0050690; GO:0070062 0 0 0 PF00928;PF01217; Q9BXT6 CHOYP_BRAFLDRAFT_215302.1.1 m.13402 sp M10L1_HUMAN 48.489 662 290 7 4 617 519 1177 0 605 M10L1_HUMAN reviewed RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) MOV10L1 Homo sapiens (Human) 1211 DNA methylation involved in gamete generation [GO:0043046]; germ cell development [GO:0007281]; male meiosis I [GO:0007141]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0000287; GO:0003723; GO:0004004; GO:0005524; GO:0005622; GO:0007141; GO:0007275; GO:0007281; GO:0007283; GO:0034587; GO:0043046; GO:0043186; GO:0071546 0 0 0 0 Q9BXW9 CHOYP_BRAFLDRAFT_216683.1.1 m.17273 sp FACD2_HUMAN 43.129 997 540 13 6 979 449 1441 0 752 FACD2_HUMAN reviewed Fanconi anemia group D2 protein (Protein FACD2) FANCD2 FACD Homo sapiens (Human) 1451 gamete generation [GO:0007276]; interstrand cross-link repair [GO:0036297]; response to gamma radiation [GO:0010332]; synapsis [GO:0007129] GO:0000793; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007129; GO:0007276; GO:0010332; GO:0036297; GO:0070182 0 0 0 PF14631; Q9BY12 CHOYP_SCAPER.1.1 m.34551 sp SCAPE_HUMAN 39.797 1480 756 36 49 1485 7 1394 0 899 SCAPE_HUMAN reviewed S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) SCAPER KIAA1454 ZNF291 MSTP063 Homo sapiens (Human) 1400 0 GO:0003676; GO:0005634; GO:0005737; GO:0005783; GO:0008270 0 0 0 PF16501; Q9BYV1 CHOYP_TRIADDRAFT_63204.1.2 m.30701 sp AGT2_HUMAN 56.319 451 193 3 21 470 44 491 0 563 AGT2_HUMAN reviewed "Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-AIBAT)" AGXT2 AGT2 Homo sapiens (Human) 514 "glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; L-alanine catabolic process, by transamination [GO:0019481]; positive regulation of nitric oxide biosynthetic process [GO:0045429]" GO:0005739; GO:0005759; GO:0008453; GO:0009436; GO:0016223; GO:0019265; GO:0019481; GO:0030170; GO:0042802; GO:0045429; GO:0046487; GO:0047305 0 0 cd00610; PF00202; Q9BZ29 CHOYP_DOCK9.1.2 m.7649 sp DOCK9_HUMAN 44.965 2135 1033 38 4 2076 14 2068 0 1743 DOCK9_HUMAN reviewed Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) DOCK9 KIAA1058 Homo sapiens (Human) 2069 blood coagulation [GO:0007596]; small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005829; GO:0005913; GO:0007264; GO:0007596; GO:0012505; GO:0016020; GO:0098641 0 0 0 PF06920;PF14429;PF11878;PF00169; Q9BZ72 CHOYP_PITM2.2.2 m.9717 sp PITM2_HUMAN 42.283 1393 595 30 1 1274 1 1303 0 1019 PITM2_HUMAN reviewed "Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)" PITPNM2 KIAA1457 NIR3 Homo sapiens (Human) 1349 metabolic process [GO:0008152]; transport [GO:0006810] GO:0005509; GO:0006810; GO:0008152; GO:0008289; GO:0012505; GO:0016021; GO:0043231 0 0 0 PF02862;PF02121; Q9BZE4 CHOYP_LOC100370136.1.1 m.2170 sp NOG1_HUMAN 64.874 595 195 7 1 589 48 634 0 779 NOG1_HUMAN reviewed Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB) GTPBP4 CRFG NOG1 Homo sapiens (Human) 634 negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of collagen binding [GO:0033342]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; protein stabilization [GO:0050821]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; ribosome biogenesis [GO:0042254] GO:0000079; GO:0001649; GO:0003924; GO:0005525; GO:0005634; GO:0005730; GO:0005737; GO:0005794; GO:0008156; GO:0008285; GO:0016020; GO:0022408; GO:0030336; GO:0031397; GO:0031965; GO:0033342; GO:0042254; GO:0044822; GO:0048471; GO:0050821 0 0 0 PF06858;PF08155; Q9BZF3 CHOYP_OSBL6.1.1 m.24967 sp OSBL6_HUMAN 45.089 896 429 18 89 952 70 934 0 746 OSBL6_HUMAN reviewed Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) OSBPL6 ORP6 Homo sapiens (Human) 934 lipid transport [GO:0006869] GO:0005789; GO:0005829; GO:0005886; GO:0006869; GO:0008289; GO:0031965; GO:0097038 0 0 0 PF01237; Q9BZH6 CHOYP_WDR11.2.2 m.58625 sp WDR11_HUMAN 47.63 1266 595 15 9 1263 6 1214 0 1180 WDR11_HUMAN reviewed WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) WDR11 BRWD2 KIAA1351 WDR15 Homo sapiens (Human) 1224 0 GO:0005634; GO:0005737; GO:0005765; GO:0015630; GO:0016020; GO:0016021 0 0 0 0 Q9BZJ0 CHOYP_CRNL1.1.1 m.2792 sp CRNL1_HUMAN 75.151 664 163 1 8 671 169 830 0 1058 CRNL1_HUMAN reviewed Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) CRNKL1 CRN CGI-201 MSTP021 Homo sapiens (Human) 848 "mitophagy in response to mitochondrial depolarization [GO:0098779]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of defense response to virus by host [GO:0002230]; spliceosomal complex assembly [GO:0000245]; xenophagy [GO:0098792]" GO:0000245; GO:0000398; GO:0000974; GO:0002230; GO:0003723; GO:0005681; GO:0005737; GO:0016607; GO:0044822; GO:0071010; GO:0071011; GO:0071012; GO:0071013; GO:0071014; GO:0098779; GO:0098792 0 0 0 PF02184; Q9BZZ5 CHOYP_API5.1.1 m.17066 sp API5_HUMAN 55.819 507 207 6 1 502 1 495 0 568 API5_HUMAN reviewed Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) API5 MIG8 Homo sapiens (Human) 524 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of fibroblast apoptotic process [GO:2000270] GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006915; GO:0016020; GO:0017134; GO:0043066; GO:0044822; GO:2000270 0 0 0 PF05918; Q9C093 CHOYP_LOC100181095.1.1 m.8314 sp SPEF2_HUMAN 40.97 1279 666 21 1 1264 1 1205 0 873 SPEF2_HUMAN reviewed Sperm flagellar protein 2 (Protein KPL2) SPEF2 KIAA1770 KPL2 Homo sapiens (Human) 1822 axoneme assembly [GO:0035082]; brain morphogenesis [GO:0048854]; embryonic neurocranium morphogenesis [GO:0048702]; fertilization [GO:0009566]; immune system development [GO:0002520]; multicellular organism aging [GO:0010259]; respiratory system development [GO:0060541]; spermatogenesis [GO:0007283] GO:0002177; GO:0002520; GO:0005794; GO:0007283; GO:0009566; GO:0010259; GO:0035082; GO:0048702; GO:0048854; GO:0060541; GO:0097225 0 0 0 PF06294; Q9C093 CHOYP_SPEF2.1.1 m.21599 sp SPEF2_HUMAN 41.355 1255 672 19 23 1263 1 1205 0 879 SPEF2_HUMAN reviewed Sperm flagellar protein 2 (Protein KPL2) SPEF2 KIAA1770 KPL2 Homo sapiens (Human) 1822 axoneme assembly [GO:0035082]; brain morphogenesis [GO:0048854]; embryonic neurocranium morphogenesis [GO:0048702]; fertilization [GO:0009566]; immune system development [GO:0002520]; multicellular organism aging [GO:0010259]; respiratory system development [GO:0060541]; spermatogenesis [GO:0007283] GO:0002177; GO:0002520; GO:0005794; GO:0007283; GO:0009566; GO:0010259; GO:0035082; GO:0048702; GO:0048854; GO:0060541; GO:0097225 0 0 0 PF06294; Q9C0B0 CHOYP_BRAFLDRAFT_64737.1.1 m.40499 sp UNK_HUMAN 46.098 820 367 21 37 820 26 806 0 641 UNK_HUMAN reviewed RING finger protein unkempt homolog (Zinc finger CCCH domain-containing protein 5) UNK KIAA1753 ZC3H5 ZC3HDC5 Homo sapiens (Human) 810 cell morphogenesis involved in neuron differentiation [GO:0048667]; negative regulation of cytoplasmic translation [GO:2000766]; neuron migration [GO:0001764] GO:0001764; GO:0005737; GO:0005844; GO:0044822; GO:0046872; GO:0048667; GO:1990715; GO:2000766 0 0 0 PF00642; Q9C0D3 CHOYP_ISCW_ISCW018108.1.1 m.43365 sp ZY11B_HUMAN 43.369 754 384 14 55 793 15 740 0 574 ZY11B_HUMAN reviewed Protein zyg-11 homolog B ZYG11B KIAA1730 Homo sapiens (Human) 744 regulation of ubiquitin-protein transferase activity [GO:0051438] GO:0004842; GO:0031462; GO:0051438 0 0 0 0 Q9C0G6 CHOYP_DNAH6.1.3 m.18420 sp DYH6_HUMAN 59.253 4177 1594 28 51 4172 33 4156 0 5079 DYH6_HUMAN reviewed "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) 4158 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q9C0G6 CHOYP_DNAH6.2.3 m.21512 sp DYH6_HUMAN 65.06 4150 1408 17 51 4182 33 4158 0 5653 DYH6_HUMAN reviewed "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) 4158 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q9C0G6 CHOYP_DNAH6.3.3 m.26291 sp DYH6_HUMAN 64.75 4173 1407 18 51 4206 33 4158 0 5655 DYH6_HUMAN reviewed "Dynein heavy chain 6, axonemal (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)" DNAH6 DNAHC6 DNHL1 HL2 KIAA1697 Homo sapiens (Human) 4158 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q9C0I4 CHOYP_THSD7B.1.1 m.61601 sp THS7B_HUMAN 30.149 1612 941 45 32 1510 41 1600 0 627 THS7B_HUMAN reviewed Thrombospondin type-1 domain-containing protein 7B THSD7B KIAA1679 Homo sapiens (Human) 1608 0 GO:0016021 0 0 0 PF00090; Q9CQS5 CHOYP_RIOK2.1.1 m.51802 sp RIOK2_MOUSE 53.131 559 207 10 1 519 1 544 0 562 RIOK2_MOUSE reviewed Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) Riok2 Mus musculus (Mouse) 547 0 GO:0004674; GO:0005524; GO:0046872 0 0 0 PF09202; Q9CSH3 CHOYP_DIS3.1.1 m.6724 sp RRP44_MOUSE 60.688 959 356 9 1 942 1 955 0 1198 RRP44_MOUSE reviewed Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) Dis3 Kiaa1008 Rrp44 Mus musculus (Mouse) 958 CUT catabolic process [GO:0071034]; mRNA catabolic process [GO:0006402]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364] GO:0000175; GO:0000176; GO:0000177; GO:0003723; GO:0004519; GO:0005085; GO:0005654; GO:0005730; GO:0006364; GO:0006402; GO:0016020; GO:0016075; GO:0071034 0 0 0 PF13638; Q9CUS9 CHOYP_AAEL_AAEL004138.1.2 m.7303 sp SPPL3_MOUSE 70.588 374 100 5 16 381 1 372 0 521 SPPL3_MOUSE reviewed Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin-like protein 4) Sppl3 Imp2 Psl4 Usmg3 Mus musculus (Mouse) 384 membrane protein proteolysis [GO:0033619]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; signal peptide processing [GO:0006465]; T cell receptor signaling pathway [GO:0050852] GO:0005765; GO:0005791; GO:0005886; GO:0006465; GO:0007204; GO:0016020; GO:0030660; GO:0032092; GO:0033116; GO:0033619; GO:0035307; GO:0042500; GO:0042803; GO:0043231; GO:0050852; GO:0051533; GO:0070886; GO:0071458; GO:0071556 0 0 0 PF04258; Q9CUS9 CHOYP_AAEL_AAEL004138.2.2 m.27835 sp SPPL3_MOUSE 70.588 374 100 5 16 381 1 372 0 521 SPPL3_MOUSE reviewed Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin-like protein 4) Sppl3 Imp2 Psl4 Usmg3 Mus musculus (Mouse) 384 membrane protein proteolysis [GO:0033619]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; signal peptide processing [GO:0006465]; T cell receptor signaling pathway [GO:0050852] GO:0005765; GO:0005791; GO:0005886; GO:0006465; GO:0007204; GO:0016020; GO:0030660; GO:0032092; GO:0033116; GO:0033619; GO:0035307; GO:0042500; GO:0042803; GO:0043231; GO:0050852; GO:0051533; GO:0070886; GO:0071458; GO:0071556 0 0 0 PF04258; Q9CWX9 CHOYP_DDX47.1.1 m.11144 sp DDX47_MOUSE 77.384 451 98 2 18 465 1 450 0 731 DDX47_MOUSE reviewed Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) Ddx47 Mus musculus (Mouse) 455 extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mRNA processing [GO:0006397]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] GO:0004004; GO:0005524; GO:0005730; GO:0006364; GO:0006397; GO:0008380; GO:0008625; GO:0010501; GO:0016020; GO:0044822 0 0 0 PF00270;PF00271; Q9CXF4 CHOYP_TBC15.1.1 m.4226 sp TBC15_MOUSE 46.591 616 289 10 2 585 6 613 0 568 TBC15_MOUSE reviewed TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) Tbc1d15 Mus musculus (Mouse) 671 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of GTPase activity [GO:0043087]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005576; GO:0005737; GO:0005739; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0043087; GO:0070062; GO:0090630 0 0 0 PF12068;PF00566; Q9CZT4 CHOYP_BRAFLDRAFT_118680.1.1 m.14225 sp RPC5_MOUSE 43.906 722 362 13 24 716 1 708 0 559 RPC5_MOUSE reviewed DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit 5) (RNA polymerase III subunit C5) (Sex-lethal interactor homolog) Polr3e Sin Mus musculus (Mouse) 710 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003899; GO:0005666; GO:0006383; GO:0045087; GO:0051607 0 0 0 PF04801; Q9D051 CHOYP_ODPB.1.1 m.13295 sp ODPB_MOUSE 74.425 348 88 1 22 369 13 359 0 549 ODPB_MOUSE reviewed "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)" Pdhb Mus musculus (Mouse) 359 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; mitochondrial acetyl-CoA biosynthetic process from pyruvate [GO:0061732]; tricarboxylic acid cycle [GO:0006099] GO:0004738; GO:0004739; GO:0005634; GO:0005654; GO:0005739; GO:0005759; GO:0006006; GO:0006086; GO:0006099; GO:0034604; GO:0045254; GO:0061732; GO:0070062 0 0 0 PF02779;PF02780; Q9D0F6 CHOYP_KSR2.1.1 m.9852 sp RFC5_MOUSE 74.474 333 84 1 3 335 7 338 0 530 RFC5_MOUSE reviewed Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) Rfc5 Mus musculus (Mouse) 339 DNA-dependent DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] GO:0003677; GO:0005524; GO:0005634; GO:0005663; GO:0006261; GO:0019899; GO:0031390; GO:1900264 0 0 0 PF00004;PF08542; Q9D0F6 CHOYP_LOC100373830.1.1 m.25322 sp RFC5_MOUSE 74.474 333 84 1 21 353 7 338 0 531 RFC5_MOUSE reviewed Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) Rfc5 Mus musculus (Mouse) 339 DNA-dependent DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] GO:0003677; GO:0005524; GO:0005634; GO:0005663; GO:0006261; GO:0019899; GO:0031390; GO:1900264 0 0 0 PF00004;PF08542; Q9D0R2 CHOYP_SYTC.1.1 m.35709 sp SYTC_MOUSE 72.607 679 182 2 35 710 45 722 0 1056 SYTC_MOUSE reviewed "Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS)" Tars Mus musculus (Mouse) 722 threonyl-tRNA aminoacylation [GO:0006435] GO:0003723; GO:0004829; GO:0005524; GO:0005737; GO:0006435; GO:0015629; GO:0070062 0 0 cd00771; PF03129;PF02824;PF00587;PF07973; Q9D0R4 CHOYP_LOC101168798.1.1 m.6128 sp DDX56_MOUSE 55.154 553 222 9 3 549 4 536 0 580 DDX56_MOUSE reviewed Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 56) Ddx56 D11Ertd619e Noh61 Mus musculus (Mouse) 546 RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364] GO:0004004; GO:0005524; GO:0005730; GO:0006364; GO:0010501; GO:0016020; GO:0044822 0 0 0 PF00270;PF00271; Q9D180 CHOYP_LOC100371909.1.1 m.30745 sp CFA57_MOUSE 56.742 1246 495 14 1 1211 1 1237 0 1441 CFA57_MOUSE reviewed Cilia- and flagella-associated protein 57 (WD repeat-containing protein 65) Cfap57 Wdr65 Mus musculus (Mouse) 1249 0 0 0 0 0 PF00400; Q9D1A2 CHOYP_CNDP2.2.4 m.25845 sp CNDP2_MOUSE 69.351 447 136 1 39 484 1 447 0 668 CNDP2_MOUSE reviewed Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) Cndp2 Cn2 Mus musculus (Mouse) 475 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004180; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0008233; GO:0008270; GO:0016805; GO:0043171; GO:0070062; GO:0070573; GO:0102008 0 0 cd05676; PF07687;PF01546; Q9D1A2 CHOYP_CNDP2.3.4 m.30467 sp CNDP2_MOUSE 69.979 473 141 1 1 472 1 473 0 713 CNDP2_MOUSE reviewed Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) Cndp2 Cn2 Mus musculus (Mouse) 475 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004180; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0008233; GO:0008270; GO:0016805; GO:0043171; GO:0070062; GO:0070573; GO:0102008 0 0 cd05676; PF07687;PF01546; Q9D2J7 CHOYP_ANKRD5.1.2 m.11711 sp ANKE1_MOUSE 45.083 783 409 6 1 776 1 769 0 676 ANKE1_MOUSE reviewed Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) Ankef1 Ankrd5 Mus musculus (Mouse) 775 0 0 0 0 0 PF12796; Q9D2K4 CHOYP_LOC100368865.1.1 m.48100 sp IQCH_MOUSE 43.502 1085 552 13 3 1081 14 1043 0 913 IQCH_MOUSE reviewed IQ domain-containing protein H Iqch Mus musculus (Mouse) 1071 0 0 0 0 0 0 Q9D4D4 CHOYP_BRAFLDRAFT_82353.1.1 m.13454 sp TKTL2_MOUSE 65.366 615 210 2 117 730 9 621 0 842 TKTL2_MOUSE reviewed Transketolase-like protein 2 (EC 2.2.1.1) Tktl2 Mus musculus (Mouse) 627 metabolic process [GO:0008152] GO:0004802; GO:0005737; GO:0008152; GO:0046872 0 0 0 PF02779;PF02780;PF00456; Q9D4H8 CHOYP_CUL2.1.1 m.59278 sp CUL2_MOUSE 58.635 747 303 4 36 778 1 745 0 939 CUL2_MOUSE reviewed Cullin-2 (CUL-2) Cul2 Mus musculus (Mouse) 745 protein catabolic process [GO:0030163]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005654; GO:0005730; GO:0030163; GO:0030891; GO:0031462; GO:0031625; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00888;PF10557; Q9D554 CHOYP_SF3A3.1.1 m.50392 sp SF3A3_MOUSE 72.51 502 137 1 39 540 1 501 0 743 SF3A3_MOUSE reviewed Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61) Sf3a3 Sap61 Mus musculus (Mouse) 501 "mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003723; GO:0005654; GO:0005681; GO:0006397; GO:0008270; GO:0044822; GO:0071013 0 0 0 PF11931;PF16837;PF12108; Q9D5E4 CHOYP_LOC100313649.1.1 m.49801 sp DRC3_MOUSE 53.95 519 238 1 1 519 1 518 0 566 DRC3_MOUSE reviewed Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48) Drc3 Lrrc48 Mus musculus (Mouse) 523 0 GO:0005737; GO:0005930 0 0 0 0 Q9D6R2 CHOYP_LOC587700.1.1 m.42534 sp IDH3A_MOUSE 71.745 361 98 3 35 392 5 364 0 531 IDH3A_MOUSE reviewed "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)" Idh3a Mus musculus (Mouse) 366 tricarboxylic acid cycle [GO:0006099] GO:0000287; GO:0004449; GO:0005634; GO:0005739; GO:0006099; GO:0043209; GO:0051287 0 0 0 PF00180; Q9D6T1 CHOYP_LOC100374494.1.1 m.14774 sp TBE_MOUSE 67.762 487 139 4 7 489 1 473 0 677 TBE_MOUSE reviewed Tubulin epsilon chain (Epsilon-tubulin) Tube1 Mus musculus (Mouse) 475 microtubule-based process [GO:0007017] GO:0003924; GO:0005525; GO:0005737; GO:0005815; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q9D787 CHOYP_PPIL2.1.1 m.55184 sp PPIL2_MOUSE 60.714 532 189 8 1 523 1 521 0 621 PPIL2_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase-like 2 (PPIase) (EC 5.2.1.8) (EC 6.3.2.-) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Rotamase PPIL2) Ppil2 Mus musculus (Mouse) 521 protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0003755; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0006457; GO:0016874; GO:0034450; GO:0061630; GO:0072659 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q13356}. 0 0 PF00160; Q9D7B6 CHOYP_ACAD8.1.1 m.9135 sp ACAD8_MOUSE 71.466 382 109 0 38 419 32 413 0 586 ACAD8_MOUSE reviewed "Isobutyryl-CoA dehydrogenase, mitochondrial (EC 1.3.99.-) (Acyl-CoA dehydrogenase family member 8) (ACAD-8)" Acad8 Mus musculus (Mouse) 413 branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088]; valine catabolic process [GO:0006574] GO:0000062; GO:0003995; GO:0005739; GO:0006574; GO:0009055; GO:0009083; GO:0033539; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Amino-acid degradation; L-valine degradation. 0 0 PF00441;PF02770;PF02771; Q9D8W5 CHOYP_BRAFLDRAFT_113849.1.1 m.53398 sp PSD12_MOUSE 68.49 457 139 2 1 453 1 456 0 654 PSD12_MOUSE reviewed 26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55) Psmd12 Mus musculus (Mouse) 456 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0000502; GO:0005737; GO:0005838; GO:0008541; GO:0016020; GO:0022624; GO:0031595; GO:0043161; GO:0070062 0 0 0 PF01399; Q9D906 CHOYP_ATG7.1.1 m.34175 sp ATG7_MOUSE 55.202 692 289 9 39 712 8 696 0 783 ATG7_MOUSE reviewed Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7) (Autophagy-related protein 7) (APG7-like) (mAGP7) (Ubiquitin-activating enzyme E1-like protein) Atg7 Apg7l Mus musculus (Mouse) 698 adult walking behavior [GO:0007628]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cardiac muscle cell development [GO:0055013]; cellular amino acid metabolic process [GO:0006520]; cellular homeostasis [GO:0019725]; cellular response to hyperoxia [GO:0071455]; cellular response to nitrogen starvation [GO:0006995]; cellular response to reactive oxygen species [GO:0034614]; cellular response to starvation [GO:0009267]; cellular sphingolipid homeostasis [GO:0090156]; central nervous system neuron axonogenesis [GO:0021955]; cerebellar Purkinje cell layer development [GO:0021680]; cerebral cortex development [GO:0021987]; C-terminal protein lipidation [GO:0006501]; defense response to virus [GO:0051607]; late nucleophagy [GO:0044805]; liver development [GO:0001889]; macroautophagy [GO:0016236]; membrane organization [GO:0061024]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000422]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell death [GO:0060548]; negative regulation of histone H4-K16 acetylation [GO:2000619]; negative regulation of phagocytosis [GO:0050765]; negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis [GO:0090157]; negative stranded viral RNA replication [GO:0039689]; neurological system process [GO:0050877]; neuron projection development [GO:0031175]; organelle organization [GO:0006996]; piecemeal microautophagy of nucleus [GO:0034727]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mucus secretion [GO:0070257]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein modification process [GO:0031401]; post-embryonic development [GO:0009791]; protein catabolic process [GO:0030163]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031]; pyramidal neuron development [GO:0021860]; regulation of cell development [GO:0060284]; regulation of hemopoiesis [GO:1903706]; regulation of mitophagy [GO:1903146]; regulation of protein ubiquitination [GO:0031396]; response to starvation [GO:0042594]; suppression by virus of host autophagy [GO:0039521] GO:0000045; GO:0000407; GO:0000422; GO:0001889; GO:0005737; GO:0005829; GO:0005930; GO:0006497; GO:0006501; GO:0006520; GO:0006914; GO:0006995; GO:0006996; GO:0007005; GO:0007628; GO:0008134; GO:0009267; GO:0009791; GO:0010508; GO:0015031; GO:0016236; GO:0016239; GO:0019725; GO:0019778; GO:0019779; GO:0021680; GO:0021860; GO:0021955; GO:0021987; GO:0030163; GO:0031175; GO:0031396; GO:0031401; GO:0032436; GO:0032446; GO:0034614; GO:0034727; GO:0035774; GO:0039521; GO:0039689; GO:0042594; GO:0042803; GO:0043065; GO:0043066; GO:0044805; GO:0045732; GO:0050765; GO:0050877; GO:0051607; GO:0055013; GO:0060284; GO:0060548; GO:0061024; GO:0070257; GO:0071455; GO:0090156; GO:0090157; GO:1903146; GO:1903706; GO:2000619 0 0 0 PF16420;PF00899; Q9D9V7 CHOYP_LOC100372051.1.1 m.54833 sp DEN6B_MOUSE 58.258 551 224 3 43 588 33 582 0 680 DEN6B_MOUSE reviewed Protein DENND6B (DENN domain-containing protein 6B) Dennd6b Mus musculus (Mouse) 585 positive regulation of GTPase activity [GO:0043547] GO:0017112; GO:0043547; GO:0055037 0 0 0 PF09794; Q9DBA9 CHOYP_TF2H1.1.1 m.15444 sp TF2H1_MOUSE 53.357 566 233 5 1 559 1 542 0 604 TF2H1_MOUSE reviewed General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) Gtf2h1 Mus musculus (Mouse) 547 nucleotide-excision repair [GO:0006289]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein phosphorylation [GO:0006468]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000439; GO:0005634; GO:0005654; GO:0005675; GO:0006289; GO:0006366; GO:0006468; GO:0045944 0 0 0 PF03909;PF08567; Q9DBC0 CHOYP_SELO.1.1 m.65007 sp SELO_MOUSE 54.348 644 256 10 42 672 46 664 0 707 SELO_MOUSE reviewed Selenoprotein O (SelO) Selo Mus musculus (Mouse) 667 0 0 0 0 0 PF02696; Q9DBE9 CHOYP_LOC660067.1.1 m.20126 sp SPB1_MOUSE 46.246 839 386 15 1 790 1 823 0 663 SPB1_MOUSE reviewed pre-rRNA processing protein FTSJ3 (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase SPB1 homolog) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3) Ftsj3 Mus musculus (Mouse) 838 "enzyme-directed rRNA 2'-O-methylation [GO:0000453]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; rRNA methylation [GO:0031167]" GO:0000453; GO:0000463; GO:0000466; GO:0005634; GO:0005730; GO:0008650; GO:0016435; GO:0030687; GO:0030688; GO:0031167; GO:0044822 0 0 0 PF11861;PF01728;PF07780; Q9DBG7 CHOYP_LOC100645380.1.1 m.14246 sp SRPRA_MOUSE 58.841 656 238 12 1 644 1 636 0 738 SRPRA_MOUSE reviewed Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) Srpra Srpr Mus musculus (Mouse) 636 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0003924; GO:0005047; GO:0005525; GO:0005785; GO:0006614; GO:0016020; GO:0044822; GO:0070062 0 0 0 PF04086;PF00448;PF02881; Q9DBP0 CHOYP_SLC34A2.1.2 m.9501 sp NPT2B_MOUSE 53.476 561 227 6 29 562 60 613 0 540 NPT2B_MOUSE reviewed Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) Slc34a2 Npt2b Mus musculus (Mouse) 697 cellular phosphate ion homeostasis [GO:0030643]; in utero embryonic development [GO:0001701]; phosphate ion transport [GO:0006817]; response to estrogen [GO:0043627] GO:0001701; GO:0005315; GO:0005436; GO:0005737; GO:0005903; GO:0006817; GO:0015321; GO:0016021; GO:0016324; GO:0030643; GO:0031402; GO:0031982; GO:0042301; GO:0043627 0 0 0 PF02690; Q9DBU0 CHOYP_LOC100555295.1.1 m.51356 sp TM9S1_MOUSE 67.426 571 179 2 26 589 36 606 0 807 TM9S1_MOUSE reviewed Transmembrane 9 superfamily member 1 Tm9sf1 Mus musculus (Mouse) 606 autophagy [GO:0006914] GO:0000421; GO:0005765; GO:0006914; GO:0016021; GO:0031410 0 0 0 PF02990; Q9DBV3 CHOYP_LOC586878.1.1 m.55678 sp DHX34_MOUSE 49.252 1137 532 16 55 1172 30 1140 0 1127 DHX34_MOUSE reviewed Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) Dhx34 Ddx34 Kiaa0134 Mus musculus (Mouse) 1145 "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; RNA processing [GO:0006396]" GO:0000956; GO:0004004; GO:0005524; GO:0005634; GO:0005739; GO:0006396; GO:0016020; GO:0044822; GO:2000623 0 0 0 PF00270;PF04408;PF00271;PF07717; Q9DC48 CHOYP_LOC100117917.1.1 m.21225 sp PRP17_MOUSE 69.145 538 164 2 387 924 44 579 0 823 PRP17_MOUSE reviewed Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (PRP17 homolog) Cdc40 Prp17 Prpf17 Mus musculus (Mouse) 579 generation of catalytic spliceosome for second transesterification step [GO:0000350] GO:0000350; GO:0044822; GO:0071013 0 0 0 PF00400; Q9DC48 CHOYP_LOC100883571.1.1 m.42322 sp PRP17_MOUSE 69.331 538 163 2 81 618 44 579 0 805 PRP17_MOUSE reviewed Pre-mRNA-processing factor 17 (Cell division cycle 40 homolog) (PRP17 homolog) Cdc40 Prp17 Prpf17 Mus musculus (Mouse) 579 generation of catalytic spliceosome for second transesterification step [GO:0000350] GO:0000350; GO:0044822; GO:0071013 0 0 0 PF00400; Q9DC53 CHOYP_CPNE8.1.2 m.41641 sp CPNE8_MOUSE 64.739 536 184 5 4 536 25 558 0 726 CPNE8_MOUSE reviewed Copine-8 (Copine VIII) Cpne8 Mus musculus (Mouse) 577 0 GO:0070062 0 0 0 PF00168;PF07002; Q9DC53 CHOYP_CPNE8.2.2 m.58379 sp CPNE8_MOUSE 62.709 539 196 5 79 614 22 558 0 700 CPNE8_MOUSE reviewed Copine-8 (Copine VIII) Cpne8 Mus musculus (Mouse) 577 0 GO:0070062 0 0 0 PF00168;PF07002; Q9DC53 CHOYP_LOC586076.1.1 m.21546 sp CPNE8_MOUSE 60.755 530 200 5 9 533 31 557 0 654 CPNE8_MOUSE reviewed Copine-8 (Copine VIII) Cpne8 Mus musculus (Mouse) 577 0 GO:0070062 0 0 0 PF00168;PF07002; Q9DCD2 CHOYP_ISCW_ISCW023297.1.1 m.11833 sp SYF1_MOUSE 66.865 842 269 4 18 849 14 855 0 1161 SYF1_MOUSE reviewed Pre-mRNA-splicing factor SYF1 (XPA-binding protein 2) Xab2 Syf1 Mus musculus (Mouse) 855 "blastocyst development [GO:0001824]; cerebral cortex development [GO:0021987]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]" GO:0000349; GO:0000974; GO:0001824; GO:0006283; GO:0006351; GO:0016020; GO:0021987; GO:0071010; GO:0071012; GO:0071013; GO:0071014 0 0 0 PF13181; Q9DE14 CHOYP_LOC580976.2.2 m.55007 sp ATR_XENLA 50.341 1027 465 11 1 1023 1669 2654 0 1071 ATR_XENLA reviewed Serine/threonine-protein kinase atr (Xatr) (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) atr Xenopus laevis (African clawed frog) 2654 DNA repair [GO:0006281]; peptidyl-serine phosphorylation [GO:0018105] GO:0003677; GO:0004674; GO:0005524; GO:0006281; GO:0016605; GO:0018105; GO:0046982 0 0 0 PF02259;PF02260;PF00454;PF08064; Q9DE26 CHOYP_RUVB1.1.1 m.25669 sp RUVB1_XENLA 87.281 456 58 0 1 456 1 456 0 832 RUVB1_XENLA reviewed RuvB-like 1 (EC 3.6.4.12) (Pontin) ruvbl1 Xenopus laevis (African clawed frog) 456 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000812; GO:0005524; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0043141; GO:0071339 0 0 0 PF06068; Q9DE27 CHOYP_RUVB2.1.1 m.19005 sp RUVB2_XENLA 87.716 464 55 1 274 737 1 462 0 833 RUVB2_XENLA reviewed RuvB-like 2 (EC 3.6.4.12) (Reptin) ruvbl2 Xenopus laevis (African clawed frog) 462 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000812; GO:0005524; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0043141; GO:0071339 0 0 0 PF06068; Q9DE46 CHOYP_LOC584095.1.1 m.6815 sp DPOLA_XENLA 54.631 1490 614 22 22 1486 6 1458 0 1533 DPOLA_XENLA reviewed DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) pola1 pola Xenopus laevis (African clawed frog) 1458 "cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272]" GO:0000166; GO:0001882; GO:0003677; GO:0003682; GO:0003887; GO:0005634; GO:0005635; GO:0005654; GO:0005658; GO:0005730; GO:0006260; GO:0006269; GO:0006270; GO:0006271; GO:0006272; GO:0006273; GO:0006303; GO:0008283; GO:0008408; GO:0016363; GO:0046872; GO:0051539 0 0 0 PF12254;PF00136;PF03104;PF08996; Q9DEB5 CHOYP_FZ10B.1.1 m.43946 sp FZ10A_XENLA 54.116 571 217 10 29 591 38 571 0 608 FZ10A_XENLA reviewed Frizzled-10-A (Fz-10A) (Xfz10-A) fzd10-a fz10a Xenopus laevis (African clawed frog) 586 multicellular organism development [GO:0007275] GO:0004930; GO:0005886; GO:0007275; GO:0016021; GO:0042813 0 0 0 PF01534;PF01392; Q9DEY9 CHOYP_BLM.1.1 m.9333 sp BLM_XENLA 47.277 808 371 17 619 1403 589 1364 0 720 BLM_XENLA reviewed Bloom syndrome protein homolog (xBLM) (EC 3.6.4.12) (RecQ helicase homolog) blm Xenopus laevis (African clawed frog) 1364 DNA double-strand break processing [GO:0000729]; DNA recombination [GO:0006310]; DNA replication [GO:0006260] GO:0000729; GO:0003677; GO:0004003; GO:0005524; GO:0005634; GO:0006260; GO:0006310; GO:0043140 0 0 0 PF08072;PF16202;PF00270;PF00271;PF00570;PF16124;PF09382; Q9DGG6 CHOYP_APLD.1.1 m.9873 sp ADCY9_CHICK 41.653 1186 570 24 47 1146 74 1223 0 852 ADCY9_CHICK reviewed Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9) ADCY9 Gallus gallus (Chicken) 1334 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933] GO:0004016; GO:0005524; GO:0005622; GO:0005886; GO:0005887; GO:0006171; GO:0007189; GO:0007193; GO:0016021; GO:0019933; GO:0046872; GO:0071880 0 0 0 PF00211; Q9EP80 CHOYP_LOC100370426.1.2 m.29156 sp PICK1_RAT 75.207 363 90 0 32 394 9 371 0 592 PICK1_RAT reviewed PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein) Pick1 Prkcabp Rattus norvegicus (Rat) 416 cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; dopamine transport [GO:0015872]; glial cell development [GO:0021782]; long term synaptic depression [GO:0060292]; monoamine transport [GO:0015844]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of cell death [GO:0060548]; negative regulation of gene expression [GO:0010629]; positive regulation of receptor internalization [GO:0002092]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein phosphorylation [GO:0006468]; receptor clustering [GO:0043113] GO:0001664; GO:0002092; GO:0005080; GO:0005102; GO:0005737; GO:0005794; GO:0005856; GO:0005886; GO:0006468; GO:0007205; GO:0008022; GO:0010629; GO:0014069; GO:0015844; GO:0015872; GO:0016887; GO:0019904; GO:0021782; GO:0030054; GO:0030425; GO:0030971; GO:0034316; GO:0035256; GO:0036294; GO:0042149; GO:0042734; GO:0042802; GO:0043005; GO:0043113; GO:0043234; GO:0045202; GO:0045211; GO:0046872; GO:0046875; GO:0048471; GO:0051015; GO:0051020; GO:0060292; GO:0060548; GO:0071933; GO:0097061; GO:0097062 0 0 0 PF06456;PF00595; Q9EPE9 CHOYP_ATP13A.1.1 m.10161 sp AT131_MOUSE 59.63 1189 438 11 3 1173 33 1197 0 1380 AT131_MOUSE reviewed Manganese-transporting ATPase 13A1 (CATP) (EC 3.6.3.-) Atp13a1 Atp13a Mus musculus (Mouse) 1200 cellular calcium ion homeostasis [GO:0006874] GO:0005524; GO:0005789; GO:0005887; GO:0006874; GO:0016020; GO:0019829; GO:0043231; GO:0046872 0 0 0 PF00122; Q9EPL8 CHOYP_IPO7.1.1 m.16806 sp IPO7_MOUSE 59.981 1037 407 6 1 1034 1 1032 0 1276 IPO7_MOUSE reviewed Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) Ipo7 Ranbp7 Mus musculus (Mouse) 1038 innate immune response [GO:0045087]; protein import into nucleus [GO:0006606]; signal transduction [GO:0007165] GO:0005635; GO:0005654; GO:0005737; GO:0005829; GO:0006606; GO:0007165; GO:0008565; GO:0016020; GO:0042393; GO:0045087 0 0 0 PF08506;PF03810; Q9EPU0 CHOYP_RENT1.1.1 m.44133 sp RENT1_MOUSE 75.577 1126 233 13 1 1097 1 1113 0 1731 RENT1_MOUSE reviewed Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (mUpf1) Upf1 Rent1 Mus musculus (Mouse) 1124 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; dosage compensation by inactivation of X chromosome [GO:0009048]; histone mRNA catabolic process [GO:0071044]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [GO:0000294]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of translational termination [GO:0006449]; telomere maintenance [GO:0000723]; telomere maintenance via semi-conservative replication [GO:0032201]" GO:0000184; GO:0000294; GO:0000723; GO:0000784; GO:0000785; GO:0000932; GO:0000956; GO:0003682; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0006260; GO:0006281; GO:0006449; GO:0008270; GO:0009048; GO:0032201; GO:0035145; GO:0042162; GO:0044530; GO:0044822; GO:0061014; GO:0061158; GO:0071044; GO:0071222; GO:0071347 0 0 0 PF04851;PF09416; Q9EQ60 CHOYP_LOC575000.1.1 m.35366 sp CAC1H_RAT 50.368 1088 402 19 17 1080 915 1888 0 882 CAC1H_RAT reviewed Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage-gated calcium channel subunit alpha Cav3.2) Cacna1h Rattus norvegicus (Rat) 2359 aldosterone biosynthetic process [GO:0032342]; calcium ion import [GO:0070509]; calcium ion transport [GO:0006816]; cortisol biosynthetic process [GO:0034651]; membrane depolarization during action potential [GO:0086010]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; sensory perception of pain [GO:0019233] GO:0005634; GO:0005737; GO:0005886; GO:0005891; GO:0006816; GO:0008332; GO:0019233; GO:0030425; GO:0032342; GO:0034651; GO:0043204; GO:0045956; GO:0046872; GO:0070509; GO:0086010 0 0 0 PF00520; Q9EQJ0 CHOYP_LOC567534.1.1 m.51204 sp TPC1_MOUSE 47.733 750 364 8 36 770 55 791 0 660 TPC1_MOUSE reviewed Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1) Tpcn1 Kiaa1169 Tpc1 Mus musculus (Mouse) 817 membrane depolarization during action potential [GO:0086010]; positive regulation of autophagy [GO:0010508] GO:0005245; GO:0005765; GO:0005886; GO:0010008; GO:0010508; GO:0016021; GO:0042802; GO:0072345; GO:0086010 0 0 0 PF00520; Q9EQW7 CHOYP_LOC100881280.1.1 m.39133 sp KI13A_MOUSE 54.364 1604 619 30 1 1533 1 1562 0 1588 KI13A_MOUSE reviewed Kinesin-like protein KIF13A Kif13a Mus musculus (Mouse) 1749 cargo loading into vesicle [GO:0035459]; cytokinesis [GO:0000910]; endosome to lysosome transport [GO:0008333]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; melanosome organization [GO:0032438]; plus-end-directed vesicle transport along microtubule [GO:0072383] GO:0000910; GO:0003777; GO:0005524; GO:0005813; GO:0005871; GO:0005874; GO:0006886; GO:0008333; GO:0010008; GO:0016887; GO:0030496; GO:0032438; GO:0032588; GO:0035459; GO:0043001; GO:0072383 0 0 0 PF12473;PF12423;PF00225;PF16183; Q9EQZ7 CHOYP_RIMS2.2.3 m.47046 sp RIMS2_MOUSE 36.585 1640 773 55 14 1530 26 1521 0 745 RIMS2_MOUSE reviewed Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2) Rims2 Rab3ip2 Rim2 Mus musculus (Mouse) 1530 calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cAMP-mediated signaling [GO:0019933]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; spontaneous neurotransmitter secretion [GO:0061669] GO:0005622; GO:0006886; GO:0007269; GO:0010628; GO:0017156; GO:0017157; GO:0019933; GO:0030054; GO:0030073; GO:0042391; GO:0043005; GO:0044325; GO:0046872; GO:0048786; GO:0048791; GO:0061669; GO:0070062; GO:0097151; GO:1903861; GO:2000463 0 0 0 PF00168;PF02318; Q9ER47 CHOYP_LOC100371738.3.3 m.49676 sp KCNH7_MOUSE 46.575 730 342 15 99 822 387 1074 0 638 KCNH7_MOUSE reviewed Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (Voltage-gated potassium channel subunit Kv11.3) Kcnh7 Erg3 Mus musculus (Mouse) 1195 regulation of membrane potential [GO:0042391] GO:0005249; GO:0005887; GO:0042391 0 0 0 PF00027;PF00520;PF13426; Q9ER60 CHOYP_SCN4A.1.1 m.1177 sp SCN4A_MOUSE 47.006 1887 806 37 7 1793 17 1809 0 1563 SCN4A_MOUSE reviewed Sodium channel protein type 4 subunit alpha (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) Scn4a Mus musculus (Mouse) 1841 membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; sodium ion transport [GO:0006814] GO:0001518; GO:0005248; GO:0005886; GO:0006814; GO:0019228; GO:0086010 0 0 0 PF00520;PF06512; Q9ER72 CHOYP_SYCC.1.1 m.11415 sp SYCC_MOUSE 62.756 733 259 6 46 765 91 822 0 957 SYCC_MOUSE reviewed "Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)" Cars Mus musculus (Mouse) 831 cysteinyl-tRNA aminoacylation [GO:0006423] GO:0000049; GO:0004817; GO:0005524; GO:0005737; GO:0005829; GO:0006423; GO:0042803; GO:0046872 0 0 cd00672; PF01406; Q9ERC5 CHOYP_LOC724747.1.1 m.59900 sp OTOF_RAT 60.497 724 229 12 69 787 1322 1993 0 890 OTOF_RAT reviewed Otoferlin (Fer-1-like protein 2) Otof Fer1l2 Rattus norvegicus (Rat) 1993 cochlea development [GO:0090102]; sensory perception of sound [GO:0007605]; synaptic vesicle exocytosis [GO:0016079] GO:0005509; GO:0005737; GO:0005783; GO:0005789; GO:0005886; GO:0007605; GO:0016021; GO:0016079; GO:0016323; GO:0030054; GO:0030672; GO:0032403; GO:0045177; GO:0045178; GO:0090102 0 0 0 PF00168;PF08150;PF08151;PF16165; Q9ERG2 CHOYP_STRN3.4.5 m.38758 sp STRN3_MOUSE 57.772 772 284 9 36 799 59 796 0 855 STRN3_MOUSE reviewed Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen) Strn3 Gs2na Sg2na Mus musculus (Mouse) 796 negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to estradiol [GO:0032355] GO:0000122; GO:0000159; GO:0003700; GO:0005654; GO:0005794; GO:0005886; GO:0030425; GO:0032355; GO:0032403; GO:0033147; GO:0043025; GO:0045944; GO:0051721; GO:0070016 0 0 0 PF08232;PF00400; Q9ERH3 CHOYP_PHUM_PHUM035190.1.1 m.16675 sp WDR7_RAT 45.155 1579 692 32 37 1535 4 1488 0 1308 WDR7_RAT reviewed WD repeat-containing protein 7 (TGF-beta resistance-associated protein TRAG) Wdr7 Trag Rattus norvegicus (Rat) 1488 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244; GO:0008021 0 0 0 PF00400; Q9ES00 CHOYP_UBE4B.1.1 m.11223 sp UBE4B_MOUSE 52.572 1069 463 10 74 1104 106 1168 0 1126 UBE4B_MOUSE reviewed Ubiquitin conjugation factor E4 B (EC 6.3.2.-) (Ubiquitin fusion degradation protein 2) Ube4b Ufd2 Ufd2a Mus musculus (Mouse) 1173 cellular protein catabolic process [GO:0044257]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; neuron projection development [GO:0031175]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein folding [GO:0006457]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to endoplasmic reticulum stress [GO:0034976]; response to UV [GO:0009411]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular trabecula myocardium morphogenesis [GO:0003222] GO:0000151; GO:0000209; GO:0003222; GO:0005524; GO:0005634; GO:0005737; GO:0006457; GO:0006511; GO:0006513; GO:0008626; GO:0009411; GO:0016567; GO:0016874; GO:0019899; GO:0031175; GO:0034450; GO:0034976; GO:0042787; GO:0043161; GO:0044257; GO:0051082; GO:0051865; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11435423}. 0 0 PF04564;PF10408; Q9ESD7 CHOYP_MYOF.3.3 m.53228 sp DYSF_MOUSE 47.766 2104 962 34 22 2025 20 2086 0 1866 DYSF_MOUSE reviewed Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) Dysf Fer1l1 Mus musculus (Mouse) 2090 muscle contraction [GO:0006936]; plasma membrane repair [GO:0001778]; vesicle fusion [GO:0006906] GO:0001778; GO:0005509; GO:0005543; GO:0005544; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0006906; GO:0006936; GO:0016021; GO:0030027; GO:0030139; GO:0030315; GO:0030659; GO:0031410; GO:0042383; GO:0070062 0 0 0 PF00168;PF08165;PF08150;PF08151;PF16165; Q9ESL4 CHOYP_MLTK.1.1 m.33789 sp MLTK_MOUSE 53.694 555 244 7 4 551 5 553 0 596 MLTK_MOUSE reviewed Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (Leucine zipper- and sterile alpha motif kinase ZAK) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) Zak Mltk Mus musculus (Mouse) 802 activation of JUN kinase activity [GO:0007257]; cell cycle arrest [GO:0007050]; cell cycle checkpoint [GO:0000075]; cytoskeleton organization [GO:0007010]; DNA damage checkpoint [GO:0000077]; embryonic digit morphogenesis [GO:0042733]; intracellular signal transduction [GO:0035556]; limb development [GO:0060173]; positive regulation of apoptotic process [GO:0043065]; protein phosphorylation [GO:0006468]; response to radiation [GO:0009314] GO:0000075; GO:0000077; GO:0000287; GO:0004674; GO:0004709; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007010; GO:0007050; GO:0007257; GO:0009314; GO:0035556; GO:0042733; GO:0043065; GO:0044822; GO:0060173 0 0 0 PF07714;PF00536; Q9ESX5 CHOYP_DKC1.1.1 m.10978 sp DKC1_MOUSE 70.776 438 119 1 17 445 26 463 0 650 DKC1_MOUSE reviewed H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1) Dkc1 Mus musculus (Mouse) 509 box H/ACA snoRNA 3'-end processing [GO:0000495]; box H/ACA snoRNA metabolic process [GO:0033979]; mRNA pseudouridine synthesis [GO:1990481]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; rRNA modification [GO:0000154]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomerase RNA stabilization [GO:0090669]; telomere maintenance via telomerase [GO:0007004] GO:0000154; GO:0000495; GO:0003720; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0007004; GO:0009982; GO:0015030; GO:0031118; GO:0031120; GO:0031429; GO:0032212; GO:0033979; GO:0034513; GO:0044822; GO:0051973; GO:0070034; GO:0072588; GO:0090661; GO:0090669; GO:1904851; GO:1904874; GO:1990481 0 0 0 PF08068;PF01472;PF16198;PF01509; Q9GP32 CHOYP_ALF.2.3 m.40474 sp ALF_ECHMU 72.452 363 100 0 24 386 1 363 0 551 ALF_ECHMU reviewed Fructose-bisphosphate aldolase (EC 4.1.2.13) FBPA Echinococcus multilocularis (Fox tapeworm) 363 glycolytic process [GO:0006096] GO:0004332; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. 0 0 PF00274; Q9GR88 CHOYP_ERF1.1.1 m.37539 sp ERF1_POLMI 89.423 416 44 0 9 424 5 420 0 787 ERF1_POLMI reviewed Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) ERF1 Polyandrocarpa misakiensis (Tunicate) 435 0 GO:0005737; GO:0016149 0 0 0 PF03463;PF03464;PF03465; Q9GV77 CHOYP_FREM2.1.1 m.31430 sp FREM2_LYTVA 46.037 3091 1602 29 43 3107 53 3103 0 2701 FREM2_LYTVA reviewed Extracellular matrix protein 3 (FREM2 homolog) ECM3 Lytechinus variegatus (Green sea urchin) (Variegated urchin) 3103 cell communication [GO:0007154]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; multicellular organism development [GO:0007275] GO:0005509; GO:0005886; GO:0007154; GO:0007156; GO:0007275; GO:0016021 0 0 0 PF03160; Q9GYZ0 CHOYP_KI15A.1.1 m.13671 sp KIF15_STRPU 39.249 1172 558 28 32 1097 10 1133 0 723 KIF15_STRPU reviewed Kinesin-like protein KIF15 (Kinesin-related protein KRP180) KIF15 Strongylocentrotus purpuratus (Purple sea urchin) 1463 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005819; GO:0005871; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF15908;PF00225; Q9GZN1 CHOYP_ARP6.1.1 m.17920 sp ARP6_HUMAN 60.804 398 152 3 1 396 1 396 0 538 ARP6_HUMAN reviewed Actin-related protein 6 (hArp6) (hARPX) ACTR6 CDA12 Homo sapiens (Human) 396 chromatin remodeling [GO:0006338] GO:0005634; GO:0005737; GO:0005856; GO:0006338 0 0 0 PF00022; Q9H0A0 CHOYP_LOC100375877.1.1 m.16493 sp NAT10_HUMAN 68.781 1009 298 8 1 1004 1 997 0 1409 NAT10_HUMAN reviewed RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) NAT10 ALP KIAA1709 Homo sapiens (Human) 1025 negative regulation of telomere maintenance via telomerase [GO:0032211]; ribosomal small subunit biogenesis [GO:0042274]; rRNA modification [GO:0000154]; tRNA acetylation [GO:0051391] GO:0000154; GO:0000784; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0008080; GO:0016020; GO:0032211; GO:0042274; GO:0044822; GO:0051391 0 0 0 PF08351;PF13718;PF05127;PF13725; Q9H0H0 CHOYP_INT2.1.1 m.52909 sp INT2_HUMAN 46.278 927 437 9 2 888 29 934 0 827 INT2_HUMAN reviewed Integrator complex subunit 2 (Int2) INTS2 KIAA1287 Homo sapiens (Human) 1204 snRNA processing [GO:0016180]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0005622; GO:0005654; GO:0016020; GO:0016021; GO:0016180; GO:0031965; GO:0032039; GO:0042795 0 0 0 PF14750; Q9H0H0 CHOYP_INTS2.1.1 m.17377 sp INT2_HUMAN 44.878 1025 479 11 1 963 152 1152 0 887 INT2_HUMAN reviewed Integrator complex subunit 2 (Int2) INTS2 KIAA1287 Homo sapiens (Human) 1204 snRNA processing [GO:0016180]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0005622; GO:0005654; GO:0016020; GO:0016021; GO:0016180; GO:0031965; GO:0032039; GO:0042795 0 0 0 PF14750; Q9H1A4 CHOYP_APC1.1.3 m.1810 sp APC1_HUMAN 47.818 1146 530 19 2 1100 790 1914 0 1035 APC1_HUMAN reviewed Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) ANAPC1 TSG24 Homo sapiens (Human) 1944 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005654; GO:0005680; GO:0005829; GO:0007067; GO:0031145; GO:0042787; GO:0043161; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12859; Q9H1A4 CHOYP_APC1.3.3 m.35283 sp APC1_HUMAN 44.07 1956 993 39 1 1907 11 1914 0 1550 APC1_HUMAN reviewed Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) ANAPC1 TSG24 Homo sapiens (Human) 1944 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005654; GO:0005680; GO:0005829; GO:0007067; GO:0031145; GO:0042787; GO:0043161; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12859; Q9H1V8 CHOYP_S620B.1.1 m.56488 sp S6A17_HUMAN 46.747 584 294 4 31 601 60 639 0 560 S6A17_HUMAN reviewed Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) SLC6A17 NTT4 Homo sapiens (Human) 727 alanine transport [GO:0032328]; brain development [GO:0007420]; glycine transport [GO:0015816]; leucine transport [GO:0015820]; neutral amino acid transport [GO:0015804]; proline transport [GO:0015824] GO:0005328; GO:0005887; GO:0007420; GO:0008021; GO:0015171; GO:0015804; GO:0015816; GO:0015820; GO:0015824; GO:0030054; GO:0030672; GO:0032328 0 0 0 PF00209; Q9H269 CHOYP_BRAFLDRAFT_105238.1.1 m.18657 sp VPS16_HUMAN 49.88 836 408 6 28 853 5 839 0 820 VPS16_HUMAN reviewed Vacuolar protein sorting-associated protein 16 homolog (hVPS16) VPS16 Homo sapiens (Human) 839 "autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of SNARE complex assembly [GO:0035542]; regulation of vacuole fusion, non-autophagic [GO:0032889]" GO:0003779; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005776; GO:0006886; GO:0008333; GO:0030136; GO:0030424; GO:0030897; GO:0031902; GO:0032889; GO:0035542; GO:0043025; GO:0055037; GO:0097352 0 0 0 PF04840;PF04841; Q9H270 CHOYP_VPS11.3.3 m.17579 sp VPS11_HUMAN 57.343 926 370 7 8 915 5 923 0 1090 VPS11_HUMAN reviewed Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) VPS11 RNF108 PP3476 Homo sapiens (Human) 941 autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vesicle docking involved in exocytosis [GO:0006904] GO:0000166; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005776; GO:0006886; GO:0006904; GO:0006914; GO:0007032; GO:0007040; GO:0008270; GO:0008333; GO:0019904; GO:0019905; GO:0030136; GO:0030139; GO:0030674; GO:0030897; GO:0031647; GO:0031902; GO:0034058; GO:0035542; GO:1902115; GO:1903364; GO:1903955; GO:2000643 0 0 0 PF00637;PF12451; Q9H2M9 CHOYP_RBGPR.1.1 m.2968 sp RBGPR_HUMAN 40.439 1412 773 21 1 1367 1 1389 0 1001 RBGPR_HUMAN reviewed Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) RAB3GAP2 KIAA0839 Homo sapiens (Human) 1393 establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; intracellular protein transport [GO:0006886]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of protein lipidation [GO:1903061]; regulation of GTPase activity [GO:0043087] GO:0005096; GO:0005737; GO:0005789; GO:0005886; GO:0006886; GO:0008047; GO:0017137; GO:0030234; GO:0043087; GO:0043234; GO:0046982; GO:0097051; GO:1903061; GO:1903373; GO:2000786 0 0 0 PF14656;PF14655; Q9H2X6 CHOYP_HIPK2.1.2 m.56201 sp HIPK2_HUMAN 55.728 838 304 20 74 862 112 931 0 863 HIPK2_HUMAN reviewed Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) HIPK2 Homo sapiens (Human) 1198 "adult walking behavior [GO:0007628]; anterior/posterior pattern specification [GO:0009952]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; erythrocyte differentiation [GO:0030218]; eye development [GO:0001654]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; modulation by virus of host morphology or physiology [GO:0019048]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; transforming growth factor beta receptor signaling pathway [GO:0007179]; voluntary musculoskeletal movement [GO:0050882]" GO:0001102; GO:0001105; GO:0001654; GO:0003714; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0006978; GO:0007179; GO:0007224; GO:0007628; GO:0008284; GO:0009952; GO:0010842; GO:0016604; GO:0016605; GO:0018105; GO:0018107; GO:0019048; GO:0030182; GO:0030218; GO:0030511; GO:0030514; GO:0030578; GO:0032092; GO:0042771; GO:0043388; GO:0043524; GO:0045766; GO:0045893; GO:0045944; GO:0046330; GO:0046332; GO:0046790; GO:0048596; GO:0050882; GO:0051091; GO:0051726; GO:0060059; GO:0060235; GO:0060395; GO:0061072; GO:0071456; GO:0090575; GO:0097193; GO:1901796 0 0 0 PF00069; Q9H2X6 CHOYP_HIPK2.2.2 m.56529 sp HIPK2_HUMAN 54.302 860 304 20 74 884 112 931 0 857 HIPK2_HUMAN reviewed Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) HIPK2 Homo sapiens (Human) 1198 "adult walking behavior [GO:0007628]; anterior/posterior pattern specification [GO:0009952]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; erythrocyte differentiation [GO:0030218]; eye development [GO:0001654]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; iris morphogenesis [GO:0061072]; lens induction in camera-type eye [GO:0060235]; modulation by virus of host morphology or physiology [GO:0019048]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; PML body organization [GO:0030578]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; regulation of signal transduction by p53 class mediator [GO:1901796]; retina layer formation [GO:0010842]; SMAD protein signal transduction [GO:0060395]; smoothened signaling pathway [GO:0007224]; transforming growth factor beta receptor signaling pathway [GO:0007179]; voluntary musculoskeletal movement [GO:0050882]" GO:0001102; GO:0001105; GO:0001654; GO:0003714; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0006978; GO:0007179; GO:0007224; GO:0007628; GO:0008284; GO:0009952; GO:0010842; GO:0016604; GO:0016605; GO:0018105; GO:0018107; GO:0019048; GO:0030182; GO:0030218; GO:0030511; GO:0030514; GO:0030578; GO:0032092; GO:0042771; GO:0043388; GO:0043524; GO:0045766; GO:0045893; GO:0045944; GO:0046330; GO:0046332; GO:0046790; GO:0048596; GO:0050882; GO:0051091; GO:0051726; GO:0060059; GO:0060235; GO:0060395; GO:0061072; GO:0071456; GO:0090575; GO:0097193; GO:1901796 0 0 0 PF00069; Q9H3E2 CHOYP_LOC100375867.2.2 m.64504 sp SNX25_HUMAN 38.347 871 486 14 94 949 1 835 0 564 SNX25_HUMAN reviewed Sorting nexin-25 SNX25 MSTP043 Homo sapiens (Human) 840 negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein transport [GO:0015031]; receptor catabolic process [GO:0032801] GO:0010008; GO:0015031; GO:0030512; GO:0032801; GO:0035091; GO:0060394 0 0 0 PF08628;PF00787;PF02194;PF00615; Q9H3G5 CHOYP_CPVL.1.2 m.2978 sp CPVL_HUMAN 58.295 434 181 0 42 475 38 471 0 534 CPVL_HUMAN reviewed "Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)" CPVL VLP PSEC0124 UNQ197/PRO223 Homo sapiens (Human) 476 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004185; GO:0051603; GO:0070062 0 0 0 PF00450; Q9H5Z1 CHOYP_DHX35.1.1 m.12985 sp DHX35_HUMAN 65.847 691 236 0 7 697 9 699 0 984 DHX35_HUMAN reviewed Probable ATP-dependent RNA helicase DHX35 (EC 3.6.4.13) (DEAH box protein 35) DHX35 C20orf15 DDX35 Homo sapiens (Human) 703 "mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]" GO:0000398; GO:0004004; GO:0005524; GO:0005737; GO:0006396; GO:0044822; GO:0071013 0 0 0 PF04408;PF00271;PF07717; Q9H6U6 CHOYP_BCAS3.1.1 m.6968 sp BCAS3_HUMAN 45.434 887 422 20 1 843 5 873 0 677 BCAS3_HUMAN reviewed Breast carcinoma-amplified sequence 3 (GAOB1) BCAS3 Homo sapiens (Human) 928 "activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; cellular response to estrogen stimulus [GO:0071391]; Golgi organization [GO:0007030]; microtubule organizing center organization [GO:0031023]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of establishment of cell polarity [GO:2000114]; response to starvation [GO:0042594]; transcription, DNA-templated [GO:0006351]; tube formation [GO:0035148]; vesicle-mediated transport [GO:0016192]" GO:0001525; GO:0003682; GO:0005634; GO:0005730; GO:0005737; GO:0005881; GO:0006351; GO:0007030; GO:0008134; GO:0010595; GO:0010698; GO:0016192; GO:0031023; GO:0031252; GO:0034260; GO:0035035; GO:0035148; GO:0035257; GO:0035327; GO:0042393; GO:0042594; GO:0043085; GO:0043547; GO:0045111; GO:0045944; GO:0048487; GO:0051491; GO:0051895; GO:0071391; GO:0071944; GO:0090316; GO:0090630; GO:2000114; GO:2000251 0 0 0 PF12490; Q9H720 CHOYP_PG2IP.1.1 m.14888 sp PG2IP_HUMAN 49.856 696 332 6 11 691 6 699 0 680 PG2IP_HUMAN reviewed PGAP2-interacting protein (Cell wall biogenesis protein 43 C-terminal homolog) CWH43 PGAP2IP Homo sapiens (Human) 699 GPI anchor biosynthetic process [GO:0006506] GO:0006506; GO:0016021 0 0 0 0 Q9H7F0 CHOYP_LOC582670.1.1 m.23815 sp AT133_HUMAN 44.905 1207 596 17 38 1183 9 1207 0 982 AT133_HUMAN reviewed Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1) ATP13A3 AFURS1 Homo sapiens (Human) 1226 cellular calcium ion homeostasis [GO:0006874] GO:0005524; GO:0005887; GO:0006874; GO:0016020; GO:0019829; GO:0043231; GO:0046872 0 0 0 PF00689;PF00690;PF00122;PF12409; Q9H7F0 CHOYP_LOC660831.1.1 m.39646 sp AT133_HUMAN 43.86 1254 587 22 23 1189 3 1226 0 981 AT133_HUMAN reviewed Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1) ATP13A3 AFURS1 Homo sapiens (Human) 1226 cellular calcium ion homeostasis [GO:0006874] GO:0005524; GO:0005887; GO:0006874; GO:0016020; GO:0019829; GO:0043231; GO:0046872 0 0 0 PF00689;PF00690;PF00122;PF12409; Q9H7F0 CHOYP_PHUM_PHUM193930.1.1 m.58261 sp AT133_HUMAN 42.95 1227 635 15 24 1205 9 1215 0 969 AT133_HUMAN reviewed Probable cation-transporting ATPase 13A3 (EC 3.6.3.-) (ATPase family homolog up-regulated in senescence cells 1) ATP13A3 AFURS1 Homo sapiens (Human) 1226 cellular calcium ion homeostasis [GO:0006874] GO:0005524; GO:0005887; GO:0006874; GO:0016020; GO:0019829; GO:0043231; GO:0046872 0 0 0 PF00689;PF00690;PF00122;PF12409; Q9H7Z6 CHOYP_KAT8.1.1 m.28310 sp KAT8_HUMAN 78.96 404 82 2 52 455 57 457 0 679 KAT8_HUMAN reviewed "Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)" KAT8 MOF MYST1 PP7073 Homo sapiens (Human) 458 "histone acetylation [GO:0016573]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; myeloid cell differentiation [GO:0030099]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of autophagy [GO:0010506]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0000776; GO:0004402; GO:0005634; GO:0005654; GO:0006351; GO:0008134; GO:0010506; GO:0016407; GO:0016573; GO:0030099; GO:0035064; GO:0043981; GO:0043982; GO:0043984; GO:0045892; GO:0045893; GO:0046872; GO:0071339; GO:0072487 0 0 0 PF01853;PF11717; Q9H845 CHOYP_LOC753939.1.1 m.44379 sp ACAD9_HUMAN 56.25 608 244 7 63 663 27 619 0 675 ACAD9_HUMAN reviewed "Acyl-CoA dehydrogenase family member 9, mitochondrial (ACAD-9) (EC 1.3.99.-)" ACAD9 Homo sapiens (Human) 621 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088]; mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0000062; GO:0003995; GO:0005634; GO:0005739; GO:0005743; GO:0009055; GO:0030425; GO:0032981; GO:0033539; GO:0050660; GO:0052890; GO:0055088 0 0 0 PF00441;PF02770;PF02771; Q9H8E8 CHOYP_BRAFLDRAFT_127142.1.1 m.18053 sp CSR2B_HUMAN 40.955 796 356 15 27 814 77 766 0 553 CSR2B_HUMAN reviewed Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) KAT14 CSRP2BP Homo sapiens (Human) 782 G2/M transition of mitotic cell cycle [GO:0000086]; histone H3 acetylation [GO:0043966] GO:0000086; GO:0004402; GO:0005634; GO:0005671; GO:0005737; GO:0030274; GO:0043966 0 0 0 PF13673; Q9H8V3 CHOYP_ECT2.1.1 m.11718 sp ECT2_HUMAN 44.31 826 394 14 37 807 41 855 0 661 ECT2_HUMAN reviewed Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) ECT2 Homo sapiens (Human) 914 activation of GTPase activity [GO:0090630]; activation of protein kinase activity [GO:0032147]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis [GO:0000902]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; cytokinesis [GO:0000910]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein import into nucleus [GO:0042307]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of protein kinase activity [GO:0045859]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0000902; GO:0000910; GO:0004871; GO:0005085; GO:0005089; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005911; GO:0005923; GO:0015031; GO:0030496; GO:0032147; GO:0032154; GO:0032467; GO:0035023; GO:0035556; GO:0042307; GO:0042803; GO:0043065; GO:0043123; GO:0043547; GO:0045666; GO:0045859; GO:0051056; GO:0051260; GO:0051988; GO:0070301; GO:0070830; GO:0071277; GO:0071479; GO:0072686; GO:0090630; GO:0097149 0 0 0 PF00533;PF12738;PF00621; Q9H9B1 CHOYP_EHMT2.1.1 m.263 sp EHMT1_HUMAN 48.196 776 385 7 821 1587 517 1284 0 780 EHMT1_HUMAN reviewed Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) EHMT1 EUHMTASE1 GLP KIAA1876 KMT1D Homo sapiens (Human) 1298 "chromatin modification [GO:0016568]; DNA methylation [GO:0006306]; embryo development [GO:0009790]; histone methylation [GO:0016571]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to fungicide [GO:0060992]" GO:0000122; GO:0002039; GO:0005634; GO:0005654; GO:0005694; GO:0006306; GO:0008168; GO:0008270; GO:0009790; GO:0016279; GO:0016568; GO:0016571; GO:0018024; GO:0018026; GO:0018027; GO:0045892; GO:0046974; GO:0046976; GO:0060992; GO:1901796 0 0 0 PF12796;PF05033;PF00856; Q9H9Y6 CHOYP_BRAFLDRAFT_223894.1.1 m.7024 sp RPA2_HUMAN 56.338 1136 476 8 8 1137 14 1135 0 1320 RPA2_HUMAN reviewed DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) POLR1B Homo sapiens (Human) 1135 "embryo implantation [GO:0007566]; nucleologenesis [GO:0017126]; positive regulation of gene expression, epigenetic [GO:0045815]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription initiation from RNA polymerase I promoter [GO:0006361]" GO:0003677; GO:0003899; GO:0005654; GO:0005730; GO:0005736; GO:0005737; GO:0006361; GO:0006362; GO:0006363; GO:0007566; GO:0009303; GO:0017126; GO:0032549; GO:0045815; GO:0046872 0 0 cd00653; PF06883;PF04563;PF04561;PF04565;PF00562;PF04560; Q9HAU4 CHOYP_SMUF2.1.1 m.14324 sp SMUF2_HUMAN 70.976 758 193 7 12 764 13 748 0 1101 SMUF2_HUMAN reviewed E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) SMURF2 Homo sapiens (Human) 748 "BMP signaling pathway [GO:0030509]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of trophoblast cell migration [GO:1901165]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent SMAD protein catabolic process [GO:0030579]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000122; GO:0000151; GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006511; GO:0016874; GO:0017015; GO:0030509; GO:0030512; GO:0030579; GO:0042787; GO:0042802; GO:0045121; GO:0045892; GO:0046332; GO:0060071; GO:0061630; GO:0090263; GO:1901165 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00168;PF00632;PF00397; Q9HAU5 CHOYP_RENT2.1.1 m.50589 sp RENT2_HUMAN 52.547 1178 534 12 197 1369 110 1267 0 1219 RENT2_HUMAN reviewed Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2) UPF2 KIAA1408 RENT2 Homo sapiens (Human) 1272 "liver development [GO:0001889]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; organ regeneration [GO:0031100]" GO:0000184; GO:0001889; GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0006406; GO:0031100; GO:0035145; GO:0042162; GO:0048471 0 0 0 PF02854;PF04050; Q9HAV4 CHOYP_XPO5.1.1 m.14207 sp XPO5_HUMAN 43.046 1208 654 13 4 1185 5 1204 0 978 XPO5_HUMAN reviewed Exportin-5 (Exp5) (Ran-binding protein 21) XPO5 KIAA1291 RANBP21 Homo sapiens (Human) 1204 gene silencing by RNA [GO:0031047]; positive regulation of RNA interference [GO:1900370]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; regulation of protein export from nucleus [GO:0046825] GO:0000049; GO:0003723; GO:0003729; GO:0005049; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006611; GO:0008536; GO:0031047; GO:0035281; GO:0042565; GO:0044822; GO:0046825; GO:0070883; GO:0090631; GO:1900370 0 0 0 PF08389; Q9HBY0 CHOYP_BRAFLDRAFT_129254.1.1 m.24978 sp NOX3_HUMAN 51.754 570 263 7 4 568 6 568 0 606 NOX3_HUMAN reviewed NADPH oxidase 3 (EC 1.6.3.-) (Mitogenic oxidase 2) (MOX-2) (gp91phox homolog 3) (GP91-3) NOX3 MOX2 Homo sapiens (Human) 568 detection of gravity [GO:0009590]; otolith development [GO:0048840]; superoxide anion generation [GO:0042554]; temperature homeostasis [GO:0001659] GO:0001659; GO:0005737; GO:0005886; GO:0009590; GO:0016175; GO:0042554; GO:0043020; GO:0048840; GO:0070062 0 0 0 PF08022;PF01794;PF08030; Q9HCD6 CHOYP_LOC658414.1.3 m.6219 sp TANC2_HUMAN 46.385 1300 617 16 791 2014 79 1374 0 1135 TANC2_HUMAN reviewed "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) 1990 in utero embryonic development [GO:0001701] GO:0001701 0 0 0 PF00023;PF12796;PF13181; Q9HCD6 CHOYP_LOC658414.2.3 m.42342 sp TANC2_HUMAN 46.462 1300 616 15 737 1960 79 1374 0 1135 TANC2_HUMAN reviewed "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) 1990 in utero embryonic development [GO:0001701] GO:0001701 0 0 0 PF00023;PF12796;PF13181; Q9HCD6 CHOYP_LOC658414.3.3 m.57684 sp TANC2_HUMAN 46.519 1307 612 16 521 1751 79 1374 0 1132 TANC2_HUMAN reviewed "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) 1990 in utero embryonic development [GO:0001701] GO:0001701 0 0 0 PF00023;PF12796;PF13181; Q9HCF6 CHOYP_TRPM3.6.7 m.57064 sp TRPM3_HUMAN 54.217 1245 485 15 35 1215 61 1284 0 1355 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9HCM2 CHOYP_ISCW_ISCW007151.2.2 m.41979 sp PLXA4_HUMAN 39.372 1943 1011 60 51 1941 63 1890 0 1267 PLXA4_HUMAN reviewed Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) 1894 anterior commissure morphogenesis [GO:0021960]; branchiomotor neuron axon guidance [GO:0021785]; chemorepulsion of branchiomotor axon [GO:0021793]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sympathetic nervous system development [GO:0048485]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644] GO:0002116; GO:0005886; GO:0005887; GO:0017154; GO:0021612; GO:0021615; GO:0021637; GO:0021644; GO:0021784; GO:0021785; GO:0021793; GO:0021960; GO:0030334; GO:0048485; GO:0048841; GO:0050923; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q9HD45 CHOYP_BRAFLDRAFT_286243.1.1 m.11085 sp TM9S3_HUMAN 79.893 562 113 0 18 579 28 589 0 934 TM9S3_HUMAN reviewed Transmembrane 9 superfamily member 3 (EP70-P-iso) (SM-11044-binding protein) TM9SF3 SMBP UNQ245/PRO282 Homo sapiens (Human) 589 0 GO:0016021 0 0 0 PF02990; Q9I7F7 CHOYP_ISCW_ISCW020028.1.1 m.57937 sp PR2_DROME 53.945 545 220 11 6 543 7 527 0 587 PR2_DROME reviewed Tyrosine-protein kinase PR2 (EC 2.7.10.2) PR2 CG3969 Drosophila melanogaster (Fruit fly) 1337 cell differentiation [GO:0030154]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0006468; GO:0007169; GO:0030154; GO:0031234; GO:0038083; GO:0042127; GO:0045087 0 0 0 PF00786;PF07714;PF07653; Q9I8E6 CHOYP_COPG2.1.1 m.60836 sp COPG2_TAKRU 71.804 876 241 5 26 899 2 873 0 1319 COPG2_TAKRU reviewed Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) copg2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 873 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0005198; GO:0006886; GO:0016192; GO:0030126 0 0 0 PF01602;PF16381;PF08752; Q9I8X3 CHOYP_FGFR2.3.3 m.59530 sp FGFR3_DANRE 44.329 767 349 19 69 809 65 779 0 589 FGFR3_DANRE reviewed Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) fgfr3 Danio rerio (Zebrafish) (Brachydanio rerio) 800 apoptotic process [GO:0006915]; positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0005886; GO:0006915; GO:0008284; GO:0016021 0 0 0 PF07679;PF07714; Q9I9M5 CHOYP_FZD7A.1.1 m.29589 sp FZD1_XENLA 62.366 558 163 10 22 568 38 559 0 686 FZD1_XENLA reviewed Frizzled-1 (Fz-1) (Xfz1) fzd1 fz1 Xenopus laevis (African clawed frog) 559 multicellular organism development [GO:0007275] GO:0004930; GO:0005886; GO:0007275; GO:0016021; GO:0042813 0 0 0 PF01534;PF01392; Q9IBG7 CHOYP_BRAFLDRAFT_74063.2.5 m.9454 sp KCP_XENLA 39.269 1752 1002 35 5 1711 593 2327 0 1160 KCP_XENLA reviewed Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) 2327 0 GO:0005576 0 0 0 PF00093;PF00094; Q9IBG7 CHOYP_LOC587640.1.1 m.15911 sp KCP_XENLA 35.087 1673 894 40 482 1988 341 1987 0 833 KCP_XENLA reviewed Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) 2327 0 GO:0005576 0 0 0 PF00093;PF00094; Q9JHI5 CHOYP_IVD.1.2 m.5213 sp IVD_MOUSE 70.531 414 118 2 9 421 14 424 0 604 IVD_MOUSE reviewed "Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4)" Ivd Mus musculus (Mouse) 424 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; leucine catabolic process [GO:0006552]; lipid homeostasis [GO:0055088] GO:0000062; GO:0005739; GO:0005759; GO:0006552; GO:0008470; GO:0009055; GO:0031966; GO:0033539; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. 0 0 PF00441;PF02770;PF02771; Q9JID6 CHOYP_ACSL1.1.1 m.685 sp ACSL1_CAVPO 52.802 678 307 9 6 681 30 696 0 714 ACSL1_CAVPO reviewed Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase) ACSL1 FACL1 LACS1 Cavia porcellus (Guinea pig) 698 0 GO:0004467; GO:0005524; GO:0005741; GO:0005778; GO:0005789; GO:0102391 0 0 0 PF00501;PF13193; Q9JK91 CHOYP_MLH1.1.1 m.2652 sp MLH1_MOUSE 58.902 747 244 5 1 684 1 747 0 906 MLH1_MOUSE reviewed DNA mismatch repair protein Mlh1 (MutL protein homolog 1) Mlh1 Mus musculus (Mouse) 760 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; female meiosis chromosome segregation [GO:0016321]; homologous chromosome segregation [GO:0045143]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; isotype switching [GO:0045190]; male meiosis [GO:0007140]; male meiosis chromosome segregation [GO:0007060]; meiotic chromosome segregation [GO:0045132]; meiotic metaphase I plate congression [GO:0043060]; meiotic nuclear division [GO:0007126]; meiotic spindle midzone assembly [GO:0051257]; meiotic telomere clustering [GO:0045141]; mismatch repair [GO:0006298]; negative regulation of mitotic recombination [GO:0045950]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oogenesis [GO:0048477]; reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; somatic recombination of immunoglobulin genes involved in immune response [GO:0002204]; spermatogenesis [GO:0007283]; synapsis [GO:0007129] GO:0000289; GO:0000712; GO:0000793; GO:0000794; GO:0000795; GO:0001673; GO:0002204; GO:0003682; GO:0003697; GO:0005524; GO:0005654; GO:0005694; GO:0005712; GO:0006281; GO:0006298; GO:0006303; GO:0006974; GO:0007060; GO:0007126; GO:0007129; GO:0007131; GO:0007140; GO:0007283; GO:0008630; GO:0016020; GO:0016321; GO:0016446; GO:0016447; GO:0016887; GO:0032137; GO:0032389; GO:0043060; GO:0045132; GO:0045141; GO:0045143; GO:0045190; GO:0045950; GO:0048477; GO:0051257 0 0 0 PF01119;PF16413; Q9JKK8 CHOYP_LOC763088.1.1 m.48978 sp ATR_MOUSE 39.091 880 499 15 17 865 765 1638 0 613 ATR_MOUSE reviewed Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) Atr Kiaa4069 Mus musculus (Mouse) 2635 "cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to UV [GO:0034644]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; establishment of RNA localization to telomere [GO:0097694]; negative regulation of DNA replication [GO:0008156]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein localization to chromosome, telomeric region [GO:0070198]; protein phosphorylation [GO:0006468]; regulation of protein binding [GO:0043393]; replicative senescence [GO:0090399]" GO:0000077; GO:0001741; GO:0003677; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005694; GO:0005794; GO:0006281; GO:0006468; GO:0006974; GO:0008156; GO:0016605; GO:0018105; GO:0032212; GO:0032405; GO:0032407; GO:0034644; GO:0043393; GO:0043517; GO:0046777; GO:0070198; GO:0071480; GO:0090399; GO:0097694; GO:1904884 0 0 0 PF02259;PF02260;PF00454;PF08064; Q9JLA3 CHOYP_UGGG1.1.1 m.59266 sp UGGG1_RAT 49.084 1528 744 12 26 1532 37 1551 0 1510 UGGG1_RAT reviewed UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (rUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1) Uggt1 Gt Ugcgl1 Uggt Ugt1 Ugtr Rattus norvegicus (Rat) 1551 'de novo' posttranslational protein folding [GO:0051084]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated misfolded protein catabolic process [GO:0071712]; protein folding [GO:0006457]; protein N-linked glycosylation via asparagine [GO:0018279] GO:0003980; GO:0005783; GO:0005788; GO:0005793; GO:0006457; GO:0018279; GO:0030968; GO:0051082; GO:0051084; GO:0070062; GO:0071712 PATHWAY: Protein modification; protein glycosylation. 0 0 PF06427; Q9JLC8 CHOYP_BRAFLDRAFT_67666.4.6 m.43953 sp SACS_MOUSE 30.361 3017 1747 101 17 2820 90 2965 0 1112 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_LOC558150.4.4 m.53050 sp SACS_MOUSE 26.846 3263 1961 114 2 2969 1449 4580 0 927 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.15.15 m.64531 sp SACS_MOUSE 27.45 3479 2104 116 5 3203 372 3710 0 1009 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.8.15 m.39056 sp SACS_MOUSE 26.92 2292 1437 72 12 2156 1086 3286 0 650 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.9.15 m.42216 sp SACS_MOUSE 29.775 2089 1237 70 7 1956 968 2965 0 773 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_SACS.11.17 m.53250 sp SACS_MOUSE 26.958 4559 2816 150 17 4231 90 4478 0 1339 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_SACS.3.17 m.31557 sp SACS_MOUSE 27.668 4695 2790 167 17 4314 90 4575 0 1331 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_SACS.9.17 m.52781 sp SACS_MOUSE 27.029 4658 2870 156 31 4331 90 4575 0 1333 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLI7 CHOYP_LOC589479.1.2 m.45559 sp SPAG6_MOUSE 88.136 413 49 0 1 413 1 413 0 746 SPAG6_MOUSE reviewed Sperm-associated antigen 6 (Axoneme central apparatus protein) (Protein PF16 homolog) Spag6 Pf16 Mus musculus (Mouse) 507 sperm axoneme assembly [GO:0007288]; sperm motility [GO:0030317]; ventricular system development [GO:0021591] GO:0005634; GO:0005737; GO:0005874; GO:0007288; GO:0015630; GO:0021591; GO:0030317; GO:0097228; GO:1990716 0 0 0 PF00514;PF02985; Q9JLI7 CHOYP_LOC589479.2.2 m.57247 sp SPAG6_MOUSE 88.142 506 60 0 1 506 1 506 0 924 SPAG6_MOUSE reviewed Sperm-associated antigen 6 (Axoneme central apparatus protein) (Protein PF16 homolog) Spag6 Pf16 Mus musculus (Mouse) 507 sperm axoneme assembly [GO:0007288]; sperm motility [GO:0030317]; ventricular system development [GO:0021591] GO:0005634; GO:0005737; GO:0005874; GO:0007288; GO:0015630; GO:0021591; GO:0030317; GO:0097228; GO:1990716 0 0 0 PF00514;PF02985; Q9JLJ2 CHOYP_BRAFLDRAFT_127028.1.1 m.18415 sp AL9A1_MOUSE 56.674 487 209 2 48 532 8 494 0 577 AL9A1_MOUSE reviewed 4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC 1.2.1.47) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) Aldh9a1 Mus musculus (Mouse) 494 carnitine biosynthetic process [GO:0045329]; carnitine metabolic process [GO:0009437]; cellular aldehyde metabolic process [GO:0006081]; neurotransmitter biosynthetic process [GO:0042136]; oxidation-reduction process [GO:0055114] GO:0004029; GO:0005739; GO:0005829; GO:0006081; GO:0009437; GO:0016620; GO:0019145; GO:0042136; GO:0045329; GO:0047105; GO:0055114; GO:0070062 PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis. 0 0 PF00171; Q9JLM8 CHOYP_LOC100313589.1.1 m.31479 sp DCLK1_MOUSE 51.617 711 290 14 8 667 10 717 0 671 DCLK1_MOUSE reviewed Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) Dclk1 Dcamkl1 Dclk Mus musculus (Mouse) 756 axon extension [GO:0048675]; axonogenesis [GO:0007409]; brain development [GO:0007420]; central nervous system projection neuron axonogenesis [GO:0021952]; dendrite morphogenesis [GO:0048813]; forebrain development [GO:0030900]; intracellular signal transduction [GO:0035556]; negative regulation of protein localization to nucleus [GO:1900181]; neuron migration [GO:0001764]; peptidyl-serine phosphorylation [GO:0018105]; response to virus [GO:0009615] GO:0001764; GO:0004672; GO:0004674; GO:0005524; GO:0007409; GO:0007420; GO:0009615; GO:0014069; GO:0018105; GO:0021952; GO:0030900; GO:0035556; GO:0048675; GO:0048813; GO:1900181 0 0 cd01617; PF03607;PF00069; Q9JLR1 CHOYP_COPA.1.1 m.31889 sp S61A2_MOUSE 88.866 476 53 0 1 476 1 476 0 872 S61A2_MOUSE reviewed Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) Sec61a2 Mus musculus (Mouse) 476 protein transport [GO:0015031] GO:0005789; GO:0015031; GO:0016021; GO:0043022 0 0 0 PF10559;PF00344; Q9JLR1 CHOYP_CPIPJ_CPIJ007723.1.4 m.5853 sp S61A2_MOUSE 89.548 354 37 0 1 354 1 354 0 648 S61A2_MOUSE reviewed Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) Sec61a2 Mus musculus (Mouse) 476 protein transport [GO:0015031] GO:0005789; GO:0015031; GO:0016021; GO:0043022 0 0 0 PF10559;PF00344; Q9JLR1 CHOYP_CPIPJ_CPIJ007723.2.4 m.11767 sp S61A2_MOUSE 88.655 476 54 0 1 476 1 476 0 869 S61A2_MOUSE reviewed Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) Sec61a2 Mus musculus (Mouse) 476 protein transport [GO:0015031] GO:0005789; GO:0015031; GO:0016021; GO:0043022 0 0 0 PF10559;PF00344; Q9JLR1 CHOYP_CPIPJ_CPIJ007723.3.4 m.30315 sp S61A2_MOUSE 88.655 476 54 0 1 476 1 476 0 869 S61A2_MOUSE reviewed Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) Sec61a2 Mus musculus (Mouse) 476 protein transport [GO:0015031] GO:0005789; GO:0015031; GO:0016021; GO:0043022 0 0 0 PF10559;PF00344; Q9JLR1 CHOYP_CPIPJ_CPIJ007723.4.4 m.64974 sp S61A2_MOUSE 88.866 476 53 0 1 476 1 476 0 872 S61A2_MOUSE reviewed Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2) Sec61a2 Mus musculus (Mouse) 476 protein transport [GO:0015031] GO:0005789; GO:0015031; GO:0016021; GO:0043022 0 0 0 PF10559;PF00344; Q9JLT4 CHOYP_TRXR2.1.1 m.10443 sp TRXR2_MOUSE 59.406 505 197 3 13 512 21 522 0 618 TRXR2_MOUSE reviewed "Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Thioredoxin reductase TR3)" Txnrd2 Trxr2 Mus musculus (Mouse) 524 cell redox homeostasis [GO:0045454]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; response to oxygen radical [GO:0000305] GO:0000305; GO:0004791; GO:0005739; GO:0007507; GO:0030097; GO:0045454; GO:0050660 0 0 0 PF07992;PF02852; Q9JM52 CHOYP_LOC100650469.1.2 m.42139 sp MINK1_MOUSE 77.174 368 68 2 7 374 9 360 0 573 MINK1_MOUSE reviewed Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Mink1 Map4k6 Mink Mus musculus (Mouse) 1308 actin cytoskeleton reorganization [GO:0031532]; chemical synaptic transmission [GO:0007268]; dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; negative thymic T cell selection [GO:0045060]; positive regulation of JNK cascade [GO:0046330]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cell migration [GO:0030334]; response to stress [GO:0006950] GO:0001952; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005794; GO:0006468; GO:0006950; GO:0007268; GO:0007275; GO:0014069; GO:0022407; GO:0030054; GO:0030334; GO:0030424; GO:0030425; GO:0031532; GO:0035556; GO:0045060; GO:0045211; GO:0046330; GO:0046777; GO:0048813; GO:0070062; GO:2000311 0 0 0 PF00780;PF00069; Q9JM52 CHOYP_LOC100650469.2.2 m.63001 sp MINK1_MOUSE 80.453 353 68 1 7 359 9 360 0 583 MINK1_MOUSE reviewed Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) Mink1 Map4k6 Mink Mus musculus (Mouse) 1308 actin cytoskeleton reorganization [GO:0031532]; chemical synaptic transmission [GO:0007268]; dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; negative thymic T cell selection [GO:0045060]; positive regulation of JNK cascade [GO:0046330]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311]; regulation of cell-cell adhesion [GO:0022407]; regulation of cell-matrix adhesion [GO:0001952]; regulation of cell migration [GO:0030334]; response to stress [GO:0006950] GO:0001952; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005794; GO:0006468; GO:0006950; GO:0007268; GO:0007275; GO:0014069; GO:0022407; GO:0030054; GO:0030334; GO:0030424; GO:0030425; GO:0031532; GO:0035556; GO:0045060; GO:0045211; GO:0046330; GO:0046777; GO:0048813; GO:0070062; GO:2000311 0 0 0 PF00780;PF00069; Q9N0E7 CHOYP_LOC583644.1.1 m.6740 sp MOCOS_BOVIN 44.683 837 411 14 28 841 39 846 0 714 MOCOS_BOVIN reviewed Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (EC 2.8.1.9) (Molybdenum cofactor sulfurtransferase) MOCOS MCSU Bos taurus (Bovine) 882 molybdopterin cofactor metabolic process [GO:0043545]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0006777; GO:0008265; GO:0016740; GO:0016829; GO:0030151; GO:0030170; GO:0043545 0 0 0 PF00266;PF03473;PF03476; Q9NGC3 CHOYP_CEG1A.4.6 m.38065 sp CEG1A_DROME 51.952 922 352 15 6 848 71 980 0 867 CEG1A_DROME reviewed Centaurin-gamma-1A CenG1A CG31811 Drosophila melanogaster (Fruit fly) 995 medium-term memory [GO:0072375]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005096; GO:0005525; GO:0005622; GO:0007264; GO:0016020; GO:0043087; GO:0043547; GO:0046872; GO:0072375 0 0 0 PF01412;PF00071; Q9NGC3 CHOYP_CEG1A.6.6 m.54758 sp CEG1A_DROME 49.11 955 358 18 16 891 75 980 0 833 CEG1A_DROME reviewed Centaurin-gamma-1A CenG1A CG31811 Drosophila melanogaster (Fruit fly) 995 medium-term memory [GO:0072375]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005096; GO:0005525; GO:0005622; GO:0007264; GO:0016020; GO:0043087; GO:0043547; GO:0046872; GO:0072375 0 0 0 PF01412;PF00071; Q9NPF5 CHOYP_BRAFLDRAFT_93876.1.1 m.8885 sp DMAP1_HUMAN 58.351 461 173 5 16 471 1 447 0 533 DMAP1_HUMAN reviewed DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) DMAP1 KIAA1425 Homo sapiens (Human) 467 "chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; DNA repair [GO:0006281]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription factor import into nucleus [GO:0042993]; regulation of growth [GO:0040008]; response to ethanol [GO:0045471]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001103; GO:0003714; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0006281; GO:0006306; GO:0006338; GO:0006351; GO:0035267; GO:0040008; GO:0042993; GO:0043967; GO:0043968; GO:0045471; GO:0045892 0 0 0 PF05499;PF16282; Q9NQW7 CHOYP_XPP1.1.2 m.16748 sp XPP1_HUMAN 59.675 615 240 5 8 615 6 619 0 771 XPP1_HUMAN reviewed "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 XPNPEPL XPNPEPL1 Homo sapiens (Human) 623 bradykinin catabolic process [GO:0010815]; proteolysis [GO:0006508] GO:0004177; GO:0005737; GO:0006508; GO:0010815; GO:0030145; GO:0042803; GO:0070006; GO:0070062 0 0 0 PF01321;PF00557;PF16188; Q9NR09 CHOYP_BIRC6.1.2 m.51516 sp BIRC6_HUMAN 39.984 5092 2434 128 1 4829 86 4818 0 3123 BIRC6_HUMAN reviewed Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) BIRC6 KIAA1289 Homo sapiens (Human) 4857 apoptotic process [GO:0006915]; cell division [GO:0051301]; labyrinthine layer development [GO:0060711]; mitotic nuclear division [GO:0007067]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127]; regulation of cytokinesis [GO:0032465]; spongiotrophoblast layer development [GO:0060712] GO:0000922; GO:0004842; GO:0004869; GO:0005768; GO:0005802; GO:0005815; GO:0006468; GO:0006915; GO:0007067; GO:0008284; GO:0016020; GO:0016567; GO:0016874; GO:0030496; GO:0032465; GO:0042127; GO:0043066; GO:0051301; GO:0060711; GO:0060712; GO:0061631; GO:2001237 0 0 0 PF00653;PF12356;PF00179; Q9NR09 CHOYP_BRAFLDRAFT_65689.1.1 m.17516 sp BIRC6_HUMAN 39.27 1342 661 32 1 1284 2163 3408 0 818 BIRC6_HUMAN reviewed Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) BIRC6 KIAA1289 Homo sapiens (Human) 4857 apoptotic process [GO:0006915]; cell division [GO:0051301]; labyrinthine layer development [GO:0060711]; mitotic nuclear division [GO:0007067]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127]; regulation of cytokinesis [GO:0032465]; spongiotrophoblast layer development [GO:0060712] GO:0000922; GO:0004842; GO:0004869; GO:0005768; GO:0005802; GO:0005815; GO:0006468; GO:0006915; GO:0007067; GO:0008284; GO:0016020; GO:0016567; GO:0016874; GO:0030496; GO:0032465; GO:0042127; GO:0043066; GO:0051301; GO:0060711; GO:0060712; GO:0061631; GO:2001237 0 0 0 PF00653;PF12356;PF00179; Q9NRC6 CHOYP_LOC100377364.2.2 m.52803 sp SPTN5_HUMAN 31.786 2671 1765 20 940 3591 862 3494 0 1273 SPTN5_HUMAN reviewed "Spectrin beta chain, non-erythrocytic 5 (Beta-V spectrin)" SPTBN5 BSPECV HUBSPECV HUSPECV Homo sapiens (Human) 3674 actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; axon guidance [GO:0007411]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lysosomal transport [GO:0007041]; MAPK cascade [GO:0000165]; protein homooligomerization [GO:0051260] GO:0000165; GO:0003779; GO:0005088; GO:0005737; GO:0005829; GO:0005875; GO:0006888; GO:0007030; GO:0007041; GO:0007411; GO:0008091; GO:0016020; GO:0019894; GO:0030036; GO:0030507; GO:0032029; GO:0032391; GO:0034452; GO:0043621; GO:0045179; GO:0045505; GO:0051260; GO:0051693; GO:0070062; GO:0097381 0 0 0 PF00307;PF00435; Q9NRH2 CHOYP_CPIPJ_CPIJ003599.1.1 m.61267 sp SNRK_HUMAN 51.654 635 243 13 11 622 4 597 0 566 SNRK_HUMAN reviewed SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) SNRK KIAA0096 SNFRK Homo sapiens (Human) 765 intracellular signal transduction [GO:0035556]; myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0030099; GO:0035556 0 0 0 PF00069; Q9NRL2 CHOYP_BAZ1A.1.1 m.9485 sp BAZ1A_HUMAN 39.294 1303 593 28 1 1210 1 1198 0 748 BAZ1A_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) BAZ1A ACF1 WCRF180 HSPC317 Homo sapiens (Human) 1556 "chromatin remodeling [GO:0006338]; DNA-dependent DNA replication [GO:0006261]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006261; GO:0006338; GO:0006351; GO:0006355; GO:0008270; GO:0008623; GO:0016590 0 0 0 PF00439;PF02791;PF00628;PF10537;PF15612;PF15613; Q9NRR4 CHOYP_RNC.1.1 m.52169 sp RNC_HUMAN 53.656 1135 487 13 214 1323 240 1360 0 1188 RNC_HUMAN reviewed Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241) DROSHA RN3 RNASE3L RNASEN Homo sapiens (Human) 1374 defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; gene silencing by RNA [GO:0031047]; miRNA metabolic process [GO:0010586]; positive regulation of gene expression [GO:0010628]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; production of siRNA involved in RNA interference [GO:0030422]; regulation of miRNA metabolic process [GO:2000628]; ribosome biogenesis [GO:0042254]; rRNA catabolic process [GO:0016075] GO:0001530; GO:0003725; GO:0004525; GO:0005654; GO:0005730; GO:0010586; GO:0010628; GO:0016075; GO:0030422; GO:0031047; GO:0031053; GO:0031054; GO:0042254; GO:0042803; GO:0044822; GO:0046872; GO:0050829; GO:0050830; GO:0070877; GO:0070878; GO:2000628 0 0 cd00593; PF00035;PF14622;PF00636; Q9NRZ9 CHOYP_HELLS.1.1 m.45903 sp HELLS_HUMAN 51.261 833 342 17 83 901 24 806 0 755 HELLS_HUMAN reviewed Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) HELLS PASG SMARCA6 Nbla10143 Homo sapiens (Human) 838 "cell division [GO:0051301]; lymphocyte proliferation [GO:0046651]; maintenance of DNA methylation [GO:0010216]; methylation-dependent chromatin silencing [GO:0006346]; mitotic nuclear division [GO:0007067]; multicellular organism development [GO:0007275]; pericentric heterochromatin assembly [GO:0031508]; transcription, DNA-templated [GO:0006351]" GO:0000775; GO:0004386; GO:0005524; GO:0005634; GO:0005721; GO:0006346; GO:0006351; GO:0007067; GO:0007275; GO:0010216; GO:0031508; GO:0046651; GO:0051301 0 0 0 PF00271;PF00176; Q9NSI6 CHOYP_BRWD1.1.1 m.42924 sp BRWD1_HUMAN 47.657 1515 701 17 14 1500 14 1464 0 1402 BRWD1_HUMAN reviewed Bromodomain and WD repeat-containing protein 1 (WD repeat-containing protein 9) BRWD1 C21orf107 WDR9 Homo sapiens (Human) 2320 "cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005730; GO:0005737; GO:0006351; GO:0006357; GO:0007010; GO:0008360 0 0 0 PF00439;PF00400; Q9NTK5 CHOYP_OLA1.2.2 m.28588 sp OLA1_HUMAN 72.051 390 106 3 1 388 1 389 0 575 OLA1_HUMAN reviewed Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9) OLA1 GTPBP9 PRO2455 PTD004 Homo sapiens (Human) 396 ATP metabolic process [GO:0046034] GO:0005524; GO:0005525; GO:0005730; GO:0005737; GO:0005813; GO:0005913; GO:0016020; GO:0016887; GO:0043022; GO:0043023; GO:0046034; GO:0046872; GO:0070062; GO:0098641 0 0 0 PF01926;PF06071; Q9NU19 CHOYP_TBC1D22A.1.1 m.24510 sp TB22B_HUMAN 56.461 503 188 7 60 533 5 505 0 556 TB22B_HUMAN reviewed TBC1 domain family member 22B TBC1D22B C6orf197 Homo sapiens (Human) 505 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0071889; GO:0090630 0 0 0 PF00566; Q9NU22 CHOYP_MDN1.4.8 m.6155 sp MDN1_HUMAN 32.838 2896 1631 73 216 2895 2797 5594 0 1248 MDN1_HUMAN reviewed Midasin (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) 5596 protein complex assembly [GO:0006461]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0006461; GO:0016020; GO:0016887; GO:0045111; GO:0051082 0 0 0 PF07728; Q9NV66 CHOYP_TYW1.1.1 m.9946 sp TYW1_HUMAN 54.483 725 282 9 1 686 10 725 0 773 TYW1_HUMAN reviewed S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein) TYW1 RSAFD1 Homo sapiens (Human) 732 oxidation-reduction process [GO:0055114]; tRNA processing [GO:0008033] GO:0008033; GO:0010181; GO:0016829; GO:0046872; GO:0051539; GO:0055114 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 PF00258;PF04055;PF08608; Q9NV70 CHOYP_EXOC1.1.2 m.60 sp EXOC1_HUMAN 50 920 410 10 1 896 1 894 0 870 EXOC1_HUMAN reviewed Exocyst complex component 1 (Exocyst complex component Sec3) EXOC1 SEC3 SEC3L1 BM-012 Homo sapiens (Human) 894 exocyst localization [GO:0051601]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of protein secretion [GO:0050714]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241] GO:0000145; GO:0005546; GO:0005737; GO:0005829; GO:0005886; GO:0006887; GO:0006893; GO:0015031; GO:0016020; GO:0016241; GO:0017049; GO:0048015; GO:0050714; GO:0051601; GO:0098592 0 0 0 PF15277;PF09763; Q9NV70 CHOYP_EXOC1.2.2 m.23516 sp EXOC1_HUMAN 50.836 897 415 8 1 874 1 894 0 875 EXOC1_HUMAN reviewed Exocyst complex component 1 (Exocyst complex component Sec3) EXOC1 SEC3 SEC3L1 BM-012 Homo sapiens (Human) 894 exocyst localization [GO:0051601]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of protein secretion [GO:0050714]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241] GO:0000145; GO:0005546; GO:0005737; GO:0005829; GO:0005886; GO:0006887; GO:0006893; GO:0015031; GO:0016020; GO:0016241; GO:0017049; GO:0048015; GO:0050714; GO:0051601; GO:0098592 0 0 0 PF15277;PF09763; Q9NV88 CHOYP_INT9.1.1 m.11703 sp INT9_HUMAN 52.345 661 304 5 1 653 1 658 0 738 INT9_HUMAN reviewed Integrator complex subunit 9 (Int9) (Protein related to CPSF subunits of 74 kDa) (RC-74) INTS9 RC74 Homo sapiens (Human) 658 snRNA processing [GO:0016180]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0005654; GO:0005737; GO:0016180; GO:0032039; GO:0042795 0 0 0 PF10996;PF16661; Q9NVE5 CHOYP_LOC577573.1.1 m.13979 sp UBP40_HUMAN 37.49 1235 711 24 30 1233 30 1234 0 746 UBP40_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40) USP40 Homo sapiens (Human) 1235 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005634; GO:0005737; GO:0006511; GO:0016579; GO:0036459 0 0 0 PF00443; Q9NVM9 CHOYP_ASUN.1.1 m.6333 sp ASUN_HUMAN 51.793 697 300 12 7 673 8 698 0 722 ASUN_HUMAN reviewed Protein asunder homolog (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Sarcoma antigen NY-SAR-95) ASUN C12orf11 GCT1 Homo sapiens (Human) 706 cell division [GO:0051301]; centrosome localization [GO:0051642]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; protein localization to nuclear envelope [GO:0090435]; regulation of fertilization [GO:0080154]; regulation of mitotic cell cycle [GO:0007346]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; sperm motility [GO:0030317] GO:0005634; GO:0005654; GO:0005737; GO:0007052; GO:0007067; GO:0007346; GO:0030317; GO:0042795; GO:0051301; GO:0051642; GO:0080154; GO:0090435 0 0 0 PF10221; Q9NVP1 CHOYP_DDX18.1.2 m.12567 sp DDX18_HUMAN 71.614 539 137 4 151 675 133 669 0 786 DDX18_HUMAN reviewed ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) DDX18 cPERP-D Homo sapiens (Human) 670 RNA secondary structure unwinding [GO:0010501] GO:0004004; GO:0005524; GO:0005694; GO:0005730; GO:0010501; GO:0016020; GO:0044822 0 0 0 PF00270;PF13959;PF00271; Q9NVP1 CHOYP_DDX18.2.2 m.51768 sp DDX18_HUMAN 70.62 548 157 4 205 751 125 669 0 790 DDX18_HUMAN reviewed ATP-dependent RNA helicase DDX18 (EC 3.6.4.13) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb) DDX18 cPERP-D Homo sapiens (Human) 670 RNA secondary structure unwinding [GO:0010501] GO:0004004; GO:0005524; GO:0005694; GO:0005730; GO:0010501; GO:0016020; GO:0044822 0 0 0 PF00270;PF13959;PF00271; Q9NVU7 CHOYP_SDA1.1.1 m.12704 sp SDA1_HUMAN 58.91 679 267 5 2 669 7 684 0 796 SDA1_HUMAN reviewed Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA) SDAD1 NUC130 Homo sapiens (Human) 687 actin cytoskeleton organization [GO:0030036]; protein transport [GO:0015031]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055] GO:0000055; GO:0005634; GO:0005730; GO:0015031; GO:0030036; GO:0042273 0 0 0 PF08158;PF05285; Q9NVX2 CHOYP_LOC585438.1.1 m.44017 sp NLE1_HUMAN 67.85 479 153 1 3 481 8 485 0 716 NLE1_HUMAN reviewed Notchless protein homolog 1 NLE1 HUSSY-07 Homo sapiens (Human) 485 hematopoietic stem cell homeostasis [GO:0061484]; inner cell mass cell differentiation [GO:0001826]; kidney development [GO:0001822]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of mitotic cell cycle [GO:0045930]; Notch signaling pathway [GO:0007219]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; ribosomal large subunit biogenesis [GO:0042273]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756] GO:0001756; GO:0001822; GO:0001826; GO:0005634; GO:0005730; GO:0007219; GO:0042273; GO:0045930; GO:0048705; GO:0061484; GO:0090263; GO:2001268 0 0 0 PF08154;PF00400; Q9NW08 CHOYP_RPC2.1.1 m.19190 sp RPC2_HUMAN 79.471 1135 225 4 5 1138 6 1133 0 1928 RPC2_HUMAN reviewed DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) POLR3B Homo sapiens (Human) 1133 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of type I interferon production [GO:0032481]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003677; GO:0003899; GO:0005654; GO:0005666; GO:0005829; GO:0006383; GO:0032481; GO:0032549; GO:0032728; GO:0045087; GO:0045089; GO:0046872; GO:0051607 0 0 cd00653; PF04563;PF04561;PF04565;PF04566;PF04567;PF00562;PF04560; Q9NW15 CHOYP_BRAFLDRAFT_75374.1.1 m.19077 sp ANO10_HUMAN 44.646 663 346 10 27 682 11 659 0 583 ANO10_HUMAN reviewed Anoctamin-10 (Transmembrane protein 16K) ANO10 TMEM16K Homo sapiens (Human) 660 cation transport [GO:0006812]; chloride transport [GO:0006821]; ion transmembrane transport [GO:0034220] GO:0005227; GO:0005229; GO:0005622; GO:0005886; GO:0006812; GO:0006821; GO:0016020; GO:0016021; GO:0034220 0 0 0 PF04547; Q9NWW7 CHOYP_LOC100370611.1.1 m.15532 sp CB042_HUMAN 53.136 574 229 12 6 570 9 551 0 593 CB042_HUMAN reviewed Uncharacterized protein C2orf42 C2orf42 Homo sapiens (Human) 574 0 GO:0005634; GO:0031965 0 0 0 PF14952; Q9NWZ5 CHOYP_AAEL_AAEL011273.1.1 m.12717 sp UCKL1_HUMAN 68.154 493 147 3 51 542 50 533 0 682 UCKL1_HUMAN reviewed Uridine-cytidine kinase-like 1 (EC 2.7.1.48) UCKL1 URKL1 F538 Homo sapiens (Human) 548 CTP salvage [GO:0044211]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]; viral process [GO:0016032] GO:0004849; GO:0005524; GO:0005634; GO:0005829; GO:0006206; GO:0016032; GO:0043097; GO:0044206; GO:0044211 PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. 0 cd06223; PF00485;PF14681; Q9NXL6 CHOYP_SIDT1.1.2 m.6274 sp SIDT1_HUMAN 45.134 822 412 13 21 829 32 827 0 700 SIDT1_HUMAN reviewed SID1 transmembrane family member 1 SIDT1 Homo sapiens (Human) 827 dsRNA transport [GO:0033227] GO:0016021; GO:0033227; GO:0051033 0 0 0 PF13965; Q9NXZ2 CHOYP_LOC101166328.1.1 m.14447 sp DDX43_HUMAN 52.475 606 270 8 140 736 46 642 0 613 DDX43_HUMAN reviewed Probable ATP-dependent RNA helicase DDX43 (EC 3.6.4.13) (Cancer/testis antigen 13) (CT13) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen) DDX43 HAGE Homo sapiens (Human) 648 RNA secondary structure unwinding [GO:0010501] GO:0003723; GO:0004004; GO:0005524; GO:0005622; GO:0010501 0 0 0 PF00270;PF00271;PF00013; Q9NY47 CHOYP_CA2D2.2.2 m.48968 sp CA2D2_HUMAN 35.649 1094 607 29 31 1064 63 1119 0 607 CA2D2_HUMAN reviewed Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] CACNA2D2 KIAA0558 Homo sapiens (Human) 1150 cardiac conduction [GO:0061337]; muscle fiber development [GO:0048747]; neuromuscular junction development [GO:0007528]; positive regulation of organ growth [GO:0046622]; regulation of insulin secretion [GO:0050796]; regulation of multicellular organism growth [GO:0040014]; rhythmic synaptic transmission [GO:0060024] GO:0005245; GO:0005886; GO:0005891; GO:0007528; GO:0040014; GO:0046622; GO:0046872; GO:0048747; GO:0050796; GO:0060024; GO:0061337 0 0 0 PF08473;PF00092;PF08399; Q9NYV4 CHOYP_CDK13.1.1 m.59965 sp CDK12_HUMAN 70.324 401 114 4 451 850 654 1050 0 605 CDK12_HUMAN reviewed "Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)" CDK12 CRK7 CRKRS KIAA0904 Homo sapiens (Human) 1490 mRNA processing [GO:0006397]; phosphorylation of RNA polymerase II C-terminal domain [GO:0070816]; protein autophosphorylation [GO:0046777]; regulation of MAP kinase activity [GO:0043405]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0002944; GO:0004672; GO:0004693; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006397; GO:0008353; GO:0008380; GO:0016607; GO:0019908; GO:0030332; GO:0043405; GO:0043484; GO:0046777; GO:0070816 0 0 0 PF00069; Q9NZJ4 CHOYP_BRAFLDRAFT_118535.4.8 m.50961 sp SACS_HUMAN 25 4728 2900 171 26 4353 90 4571 0 1065 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9NZJ4 CHOYP_BRAFLDRAFT_118535.5.8 m.53809 sp SACS_HUMAN 26.619 4726 2857 154 15 4377 96 4573 0 1184 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9NZJ4 CHOYP_BRAFLDRAFT_118535.7.8 m.56588 sp SACS_HUMAN 26.07 2593 1604 89 1 2372 2072 4572 0 682 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9NZJ4 CHOYP_BRAFLDRAFT_118535.8.8 m.61819 sp SACS_HUMAN 25.325 4699 2888 163 2 4310 90 4557 0 1086 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9NZJ4 CHOYP_SACS.14.17 m.61817 sp SACS_HUMAN 25.253 4744 2873 162 26 4358 90 4571 0 1108 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9P203 CHOYP_PHUM_PHUM195100.1.1 m.64804 sp BTBD7_HUMAN 46.387 692 343 8 19 695 36 714 0 642 BTBD7_HUMAN reviewed BTB/POZ domain-containing protein 7 BTBD7 KIAA1525 Homo sapiens (Human) 1132 multicellular organism development [GO:0007275]; regulation of branching involved in salivary gland morphogenesis [GO:0060693] GO:0005634; GO:0007275; GO:0060693 0 0 0 PF07707;PF00651; Q9P241 CHOYP_AT10A.1.1 m.56661 sp AT10D_HUMAN 42.229 1319 665 20 2 1241 37 1337 0 1019 AT10D_HUMAN reviewed Probable phospholipid-transporting ATPase VD (EC 3.6.3.1) (ATPase class V type 10D) (P4-ATPase flippase complex alpha subunit ATP10D) ATP10D ATPVD KIAA1487 Homo sapiens (Human) 1426 cation transport [GO:0006812]; ion transmembrane transport [GO:0034220]; phospholipid translocation [GO:0045332] GO:0000287; GO:0004012; GO:0005524; GO:0005654; GO:0005783; GO:0005789; GO:0005886; GO:0006812; GO:0016021; GO:0034220; GO:0045332 0 0 0 PF00122;PF16212;PF16209; Q9P2C4 CHOYP_CPIPJ_CPIJ015767.1.1 m.29058 sp TM181_HUMAN 51.631 521 235 6 3 522 105 609 0 528 TM181_HUMAN reviewed Transmembrane protein 181 TMEM181 GPR178 KIAA1423 Homo sapiens (Human) 612 pathogenesis [GO:0009405] GO:0009405; GO:0015643; GO:0016021 0 0 0 0 Q9P2D8 CHOYP_UNC79.1.4 m.71 sp UNC79_HUMAN 37.362 993 504 17 1 947 521 1441 0 650 UNC79_HUMAN reviewed Protein unc-79 homolog UNC79 KIAA1409 Homo sapiens (Human) 2635 behavioral response to ethanol [GO:0048149]; ion transmembrane transport [GO:0034220]; multicellular organism growth [GO:0035264] GO:0005886; GO:0016021; GO:0034220; GO:0035264; GO:0048149 0 0 0 0 Q9P2E3 CHOYP_LOC100371500.6.7 m.58374 sp ZNFX1_HUMAN 34.496 1290 705 32 110 1318 244 1474 0 688 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9P2E3 CHOYP_LOC100373100.3.4 m.51137 sp ZNFX1_HUMAN 35.836 1172 578 29 1888 3002 823 1877 0 674 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9P2E3 CHOYP_ZNFX1.4.12 m.24430 sp ZNFX1_HUMAN 32.241 1678 895 53 1 1592 351 1872 0 740 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9P2G1 CHOYP_LOC100368072.1.1 m.52449 sp AKIB1_HUMAN 50.941 744 335 7 1 715 1 743 0 784 AKIB1_HUMAN reviewed Ankyrin repeat and IBR domain-containing protein 1 ANKIB1 KIAA1386 Homo sapiens (Human) 1089 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005737; GO:0008270; GO:0031624; GO:0032436; GO:0042787; GO:0061630 0 0 0 PF00023;PF01485; Q9P2G9 CHOYP_BRAFLDRAFT_207414.1.2 m.17449 sp KLHL8_HUMAN 50.89 562 270 3 71 627 50 610 0 620 KLHL8_HUMAN reviewed Kelch-like protein 8 KLHL8 KIAA1378 Homo sapiens (Human) 620 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005654; GO:0016567; GO:0031463; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q9P2H3 CHOYP_BRAFLDRAFT_275667.1.1 m.17353 sp IFT80_HUMAN 63.874 764 274 1 1 764 1 762 0 1087 IFT80_HUMAN reviewed Intraflagellar transport protein 80 homolog (WD repeat-containing protein 56) IFT80 KIAA1374 WDR56 Homo sapiens (Human) 777 bone morphogenesis [GO:0060349]; chondrocyte differentiation [GO:0002062]; cilium assembly [GO:0042384]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; nonmotile primary cilium assembly [GO:0035058]; osteoblast differentiation [GO:0001649]; positive regulation of smoothened signaling pathway [GO:0045880]; smoothened signaling pathway [GO:0007224] GO:0001649; GO:0002062; GO:0005737; GO:0005813; GO:0005929; GO:0007224; GO:0030992; GO:0035058; GO:0042384; GO:0045880; GO:0050680; GO:0060349; GO:0072372; GO:0097542; GO:2000051 0 0 0 0 Q9P2J5 CHOYP_BRAFLDRAFT_63907.1.1 m.14584 sp SYLC_HUMAN 63.946 1176 416 5 5 1174 3 1176 0 1581 SYLC_HUMAN reviewed "Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)" LARS KIAA1352 Homo sapiens (Human) 1176 leucyl-tRNA aminoacylation [GO:0006429]; tRNA aminoacylation for protein translation [GO:0006418] GO:0002161; GO:0004823; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006418; GO:0006429 0 0 0 PF08264;PF00133; Q9P2K1 CHOYP_CC2D2A.1.2 m.39107 sp C2D2A_HUMAN 43.542 1564 801 23 213 1736 99 1620 0 1284 C2D2A_HUMAN reviewed Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) 1620 axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; motile cilium assembly [GO:0044458]; motile primary cilium assembly [GO:1903887]; neural tube closure [GO:0001843]; nonmotile primary cilium assembly [GO:0035058]; smoothened signaling pathway [GO:0007224] GO:0001843; GO:0005829; GO:0005856; GO:0007224; GO:0007368; GO:0007507; GO:0035058; GO:0035082; GO:0035869; GO:0036038; GO:0042384; GO:0043010; GO:0044458; GO:0060271; GO:1903887; GO:1990403 0 0 0 PF00168;PF15625; Q9P2K8 CHOYP_E2AK4.1.1 m.51429 sp E2AK4_HUMAN 39.643 1680 876 42 4 1623 47 1648 0 1043 E2AK4_HUMAN reviewed eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 Homo sapiens (Human) 1649 adaptive immune response [GO:0002250]; cell cycle arrest [GO:0007050]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to leucine starvation [GO:1990253]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; induction by virus of host autophagy [GO:0039520]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron projection extension [GO:1990138]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of translational initiation in response to starvation [GO:0071264]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of eIF2 alpha phosphorylation by amino acid starvation [GO:0060733]; regulation of feeding behavior [GO:0060259]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; T cell activation involved in immune response [GO:0002286]; viral translation [GO:0019081] GO:0000049; GO:0002230; GO:0002250; GO:0002286; GO:0002821; GO:0004674; GO:0004694; GO:0005524; GO:0005844; GO:0006446; GO:0006468; GO:0007050; GO:0007612; GO:0007616; GO:0010998; GO:0019081; GO:0022626; GO:0032057; GO:0032792; GO:0034198; GO:0034644; GO:0036492; GO:0039520; GO:0044828; GO:0045665; GO:0045947; GO:0046777; GO:0051607; GO:0060259; GO:0060733; GO:0070417; GO:0071264; GO:1900273; GO:1990138; GO:1990253 0 0 0 PF12745;PF00069;PF05773; Q9P2N4 CHOYP_ATS9.1.3 m.9223 sp ATS9_HUMAN 44.97 676 337 10 21 673 49 712 0 589 ATS9_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) 1935 glycoprotein catabolic process [GO:0006516]; multicellular organism development [GO:0007275]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; vesicle-mediated transport [GO:0016192] GO:0004222; GO:0005578; GO:0005615; GO:0005783; GO:0006508; GO:0006516; GO:0007275; GO:0008237; GO:0008270; GO:0009986; GO:0015031; GO:0016192; GO:0045636 0 0 0 PF05986;PF08685;PF01562;PF01421;PF00090; Q9P2N4 CHOYP_ATS9.3.3 m.52901 sp ATS9_HUMAN 38.382 1347 754 30 1 1316 631 1932 0 945 ATS9_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) 1935 glycoprotein catabolic process [GO:0006516]; multicellular organism development [GO:0007275]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; vesicle-mediated transport [GO:0016192] GO:0004222; GO:0005578; GO:0005615; GO:0005783; GO:0006508; GO:0006516; GO:0007275; GO:0008237; GO:0008270; GO:0009986; GO:0015031; GO:0016192; GO:0045636 0 0 0 PF05986;PF08685;PF01562;PF01421;PF00090; Q9P2P5 CHOYP_LOC100546505.1.1 m.25912 sp HECW2_HUMAN 58.382 865 299 13 880 1714 739 1572 0 1005 HECW2_HUMAN reviewed "E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2)" HECW2 KIAA1301 NEDL2 Homo sapiens (Human) 1572 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005737; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00168;PF00632;PF16562;PF00397; Q9P2S5 CHOYP_LOC100368359.2.2 m.36985 sp WRP73_HUMAN 59.251 454 181 1 1 450 1 454 0 572 WRP73_HUMAN reviewed WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) WRAP73 WDR8 Homo sapiens (Human) 460 cell projection organization [GO:0030030]; mitotic spindle assembly [GO:0090307]; positive regulation of nonmotile primary cilium assembly [GO:1902857] GO:0005813; GO:0005814; GO:0030030; GO:0036064; GO:0090307; GO:1902857 0 0 0 PF12894; Q9P2S6 CHOYP_LOC578371.1.1 m.56054 sp ANKY1_HUMAN 37.293 968 518 20 79 1006 2 920 0 587 ANKY1_HUMAN reviewed Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc finger MYND domain-containing protein 13) ANKMY1 TSAL1 ZMYND13 Homo sapiens (Human) 941 0 GO:0046872 0 0 0 PF12796;PF02493;PF01753; Q9P2T1 CHOYP_GMPR2.1.1 m.63274 sp GMPR2_HUMAN 76.204 353 78 1 1 353 1 347 0 563 GMPR2_HUMAN reviewed GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) GMPR2 Homo sapiens (Human) 348 GMP metabolic process [GO:0046037]; purine-containing compound salvage [GO:0043101]; purine nucleobase metabolic process [GO:0006144] GO:0003920; GO:0005829; GO:0006144; GO:0043101; GO:0046037; GO:0046872; GO:1902560 0 0 cd00381; PF00478; Q9PWF7 CHOYP_CATA.3.3 m.21642 sp CATA_RUGRU 69.293 495 149 2 4 496 5 498 0 731 CATA_RUGRU reviewed Catalase (EC 1.11.1.6) cat Rugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa) 528 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004096; GO:0005777; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF00199;PF06628; Q9QUG2 CHOYP_POLK.1.1 m.10206 sp POLK_MOUSE 54.426 531 217 6 73 587 14 535 0 551 POLK_MOUSE reviewed DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP) Polk Dinb1 Mus musculus (Mouse) 852 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleotide-excision repair, DNA gap filling [GO:0006297]" GO:0003684; GO:0003887; GO:0005634; GO:0005654; GO:0006260; GO:0006281; GO:0006297; GO:0043231; GO:0046872 0 0 0 PF00817;PF11799; Q9QUJ7 CHOYP_ACSL4.1.1 m.24576 sp ACSL4_MOUSE 56.151 691 298 4 19 707 21 708 0 811 ACSL4_MOUSE reviewed Long-chain-fatty-acid--CoA ligase 4 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 4) (LACS 4) (mACS4) Acsl4 Acs4 Facl4 Mus musculus (Mouse) 711 dendritic spine development [GO:0060996]; embryonic process involved in female pregnancy [GO:0060136]; fatty acid transport [GO:0015908]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; negative regulation of prostaglandin secretion [GO:0032307]; neuron differentiation [GO:0030182]; positive regulation of cell growth [GO:0030307]; regulation of fatty acid metabolic process [GO:0019217]; response to interleukin-15 [GO:0070672]; response to nutrient [GO:0007584]; triglyceride metabolic process [GO:0006641] GO:0004467; GO:0005524; GO:0005737; GO:0005739; GO:0005741; GO:0005778; GO:0005789; GO:0005811; GO:0006629; GO:0006641; GO:0007584; GO:0008610; GO:0015908; GO:0016020; GO:0016021; GO:0019217; GO:0030182; GO:0030307; GO:0031957; GO:0032307; GO:0043025; GO:0044233; GO:0047676; GO:0060136; GO:0060996; GO:0070062; GO:0070672; GO:0102391 0 0 0 PF00501; Q9QUM7 CHOYP_NEMVEDRAFT_V1G238590.1.1 m.49168 sp MSH5_MOUSE 48.181 797 393 5 54 846 49 829 0 768 MSH5_MOUSE reviewed MutS protein homolog 5 Msh5 Mus musculus (Mouse) 833 chiasma assembly [GO:0051026]; female gamete generation [GO:0007292]; meiosis I [GO:0007127]; mismatch repair [GO:0006298]; synapsis [GO:0007129] GO:0000795; GO:0005524; GO:0005654; GO:0006298; GO:0007127; GO:0007129; GO:0007292; GO:0030983; GO:0051026 0 0 0 PF05192;PF05190;PF00488; Q9QXL2 CHOYP_KI21A.1.2 m.43900 sp KI21A_MOUSE 46.509 1733 764 34 10 1668 6 1649 0 1402 KI21A_MOUSE reviewed Kinesin-like protein KIF21A Kif21a Kiaa1708 Mus musculus (Mouse) 1672 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887; GO:0030424; GO:0030425 0 0 0 PF00225;PF00400; Q9QY06 CHOYP_MYO9.2.5 m.13746 sp MYO9B_MOUSE 42.049 1308 629 23 22 1237 7 1277 0 971 MYO9B_MOUSE reviewed Unconventional myosin-IXb (Unconventional myosin-9b) Myo9b Myr5 Mus musculus (Mouse) 2114 actin filament-based movement [GO:0030048]; actin-myosin filament sliding [GO:0033275]; establishment of cell polarity [GO:0030010]; lamellipodium morphogenesis [GO:0072673]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; positive regulation of GTPase activity [GO:0043547]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] GO:0000146; GO:0001726; GO:0002548; GO:0003774; GO:0003779; GO:0005096; GO:0005516; GO:0005524; GO:0005737; GO:0005884; GO:0005938; GO:0007266; GO:0016020; GO:0016459; GO:0016887; GO:0017048; GO:0030010; GO:0030027; GO:0030048; GO:0030898; GO:0032433; GO:0033275; GO:0035023; GO:0035385; GO:0043531; GO:0043547; GO:0046872; GO:0048246; GO:0048471; GO:0048495; GO:0051015; GO:0072673 0 0 0 PF00612;PF00063;PF00788;PF00620; Q9QY06 CHOYP_MYO9.3.5 m.15644 sp MYO9B_MOUSE 38.676 861 433 14 1 810 386 1202 0 589 MYO9B_MOUSE reviewed Unconventional myosin-IXb (Unconventional myosin-9b) Myo9b Myr5 Mus musculus (Mouse) 2114 actin filament-based movement [GO:0030048]; actin-myosin filament sliding [GO:0033275]; establishment of cell polarity [GO:0030010]; lamellipodium morphogenesis [GO:0072673]; macrophage chemotaxis [GO:0048246]; monocyte chemotaxis [GO:0002548]; positive regulation of GTPase activity [GO:0043547]; regulation of Rho protein signal transduction [GO:0035023]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] GO:0000146; GO:0001726; GO:0002548; GO:0003774; GO:0003779; GO:0005096; GO:0005516; GO:0005524; GO:0005737; GO:0005884; GO:0005938; GO:0007266; GO:0016020; GO:0016459; GO:0016887; GO:0017048; GO:0030010; GO:0030027; GO:0030048; GO:0030898; GO:0032433; GO:0033275; GO:0035023; GO:0035385; GO:0043531; GO:0043547; GO:0046872; GO:0048246; GO:0048471; GO:0048495; GO:0051015; GO:0072673 0 0 0 PF00612;PF00063;PF00788;PF00620; Q9QYC7 CHOYP_LOC101067681.1.1 m.61018 sp VKGC_MOUSE 48.883 716 316 11 2 693 19 708 0 689 VKGC_MOUSE reviewed Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase) Ggcx Mus musculus (Mouse) 757 peptidyl-glutamic acid carboxylation [GO:0017187] GO:0005789; GO:0008488; GO:0016021; GO:0017187 0 0 0 PF05090; Q9QYP0 CHOYP_LOC100749345.1.1 m.40037 sp MEGF8_RAT 32.414 2212 1251 58 22 2081 633 2752 0 1041 MEGF8_RAT reviewed Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4) Megf8 Egfl4 Rattus norvegicus (Rat) 2788 BMP signaling pathway [GO:0030509]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of heart left/right asymmetry [GO:0061371]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic heart tube morphogenesis [GO:0003143]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; fasciculation of sensory neuron axon [GO:0097155]; left/right pattern formation [GO:0060972]; positive regulation of axon extension involved in axon guidance [GO:0048842]; regulation of gene expression [GO:0010468] GO:0003143; GO:0005509; GO:0005634; GO:0010468; GO:0016021; GO:0030326; GO:0030509; GO:0048704; GO:0048842; GO:0060971; GO:0060972; GO:0061371; GO:0071907; GO:0097155 0 0 0 PF00431;PF12947;PF07645;PF00053;PF01437; Q9QYP0 CHOYP_LOC101156767.1.1 m.65605 sp MEGF8_RAT 30.945 1968 1166 64 29 1887 27 1910 0 879 MEGF8_RAT reviewed Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4) Megf8 Egfl4 Rattus norvegicus (Rat) 2788 BMP signaling pathway [GO:0030509]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of heart left/right asymmetry [GO:0061371]; embryonic heart tube left/right pattern formation [GO:0060971]; embryonic heart tube morphogenesis [GO:0003143]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; fasciculation of sensory neuron axon [GO:0097155]; left/right pattern formation [GO:0060972]; positive regulation of axon extension involved in axon guidance [GO:0048842]; regulation of gene expression [GO:0010468] GO:0003143; GO:0005509; GO:0005634; GO:0010468; GO:0016021; GO:0030326; GO:0030509; GO:0048704; GO:0048842; GO:0060971; GO:0060972; GO:0061371; GO:0071907; GO:0097155 0 0 0 PF00431;PF12947;PF07645;PF00053;PF01437; Q9QYP1 CHOYP_LRP4.5.5 m.48010 sp LRP4_RAT 52.914 1527 664 15 612 2100 270 1779 0 1675 LRP4_RAT reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0034185; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q9QZ81 CHOYP_ISCW_ISCW013378.1.3 m.248 sp AGO2_RAT 67.758 611 178 2 40 648 3 596 0 861 AGO2_RAT reviewed Protein argonaute-2 (Argonaute2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Golgi ER protein 95 kDa) (GERp95) (Protein slicer) Ago2 Eif2c2 Rattus norvegicus (Rat) 860 "cell differentiation [GO:0030154]; gene silencing by RNA [GO:0031047]; miRNA mediated inhibition of translation [GO:0035278]; mRNA cleavage involved in gene silencing by miRNA [GO:0035279]; negative regulation of translational initiation [GO:0045947]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; pre-miRNA processing [GO:0031054]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000340; GO:0000932; GO:0005634; GO:0005739; GO:0005844; GO:0005845; GO:0006351; GO:0006355; GO:0016442; GO:0030154; GO:0030529; GO:0031047; GO:0031054; GO:0035068; GO:0035197; GO:0035198; GO:0035278; GO:0035279; GO:0045947; GO:0046872; GO:0060213; GO:0070551; GO:0070578; GO:1900153 0 0 0 PF08699;PF16488;PF16487;PF16486;PF02170;PF02171; Q9QZD4 CHOYP_XPF.1.1 m.14800 sp XPF_MOUSE 55.214 911 353 10 1 859 5 912 0 990 XPF_MOUSE reviewed DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) Ercc4 Mus musculus (Mouse) 917 "cellular response to UV [GO:0034644]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of telomere maintenance [GO:0032205]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; resolution of meiotic recombination intermediates [GO:0000712]; response to UV [GO:0009411]; telomere maintenance [GO:0000723]; UV protection [GO:0009650]" GO:0000014; GO:0000109; GO:0000110; GO:0000712; GO:0000723; GO:0000724; GO:0000781; GO:0000784; GO:0001094; GO:0003684; GO:0003697; GO:0004520; GO:0005634; GO:0005669; GO:0006281; GO:0006289; GO:0006295; GO:0006296; GO:0008022; GO:0009411; GO:0009650; GO:0032205; GO:0033683; GO:0034644; GO:0043566; GO:0047485; GO:0070522; GO:1901255 0 0 0 PF02732; Q9R049 CHOYP_BRAFLDRAFT_217171.1.1 m.14643 sp AMFR_MOUSE 46.28 672 301 11 48 704 1 627 0 534 AMFR_MOUSE reviewed E3 ubiquitin-protein ligase AMFR (EC 6.3.2.-) (Autocrine motility factor receptor) (AMF receptor) Amfr Mus musculus (Mouse) 643 aging [GO:0007568]; cellular process [GO:0009987]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; learning or memory [GO:0007611]; positive regulation of protein binding [GO:0032092]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein oligomerization [GO:0051259]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000166; GO:0000209; GO:0000838; GO:0004842; GO:0004872; GO:0005634; GO:0005789; GO:0005887; GO:0006511; GO:0007568; GO:0007611; GO:0008270; GO:0009987; GO:0016020; GO:0016874; GO:0030176; GO:0030425; GO:0030426; GO:0030433; GO:0030674; GO:0030968; GO:0032092; GO:0034450; GO:0036513; GO:0042787; GO:0043025; GO:0043234; GO:0048471; GO:0051087; GO:0051259; GO:0051865; GO:0061630; GO:0070936; GO:1904264; GO:1904288; GO:1990381 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02845;PF13639; Q9R085 CHOYP_UBP15.4.4 m.56615 sp UBP15_RAT 54.849 928 374 12 1 907 1 904 0 1025 UBP15_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin carboxyl-terminal hydrolase of 109 kDa) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) Usp15 ubp109 Rattus norvegicus (Rat) 952 BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; protein deubiquitination [GO:0016579]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004197; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0007179; GO:0016579; GO:0030509; GO:0035520; GO:0035616; GO:0060389 0 0 0 PF06337;PF14836;PF00443;PF14533; Q9R0H0 CHOYP_ACOX1.3.3 m.26948 sp ACOX1_MOUSE 48.714 661 326 4 7 657 1 658 0 660 ACOX1_MOUSE reviewed Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) Acox1 Acox Paox Mus musculus (Mouse) 661 fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; peroxisome fission [GO:0016559]; positive regulation of cholesterol homeostasis [GO:2000189]; prostaglandin metabolic process [GO:0006693]; spermatogenesis [GO:0007283]; very long-chain fatty acid metabolic process [GO:0000038] GO:0000038; GO:0000062; GO:0003995; GO:0003997; GO:0005102; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005777; GO:0005778; GO:0005886; GO:0006091; GO:0006629; GO:0006635; GO:0006693; GO:0007283; GO:0009055; GO:0016020; GO:0016401; GO:0016559; GO:0019395; GO:0030165; GO:0033539; GO:0033540; GO:0043231; GO:0047485; GO:0050660; GO:0052890; GO:0055088; GO:0071949; GO:2000189 PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. 0 0 PF01756;PF02770;PF14749; Q9R152 CHOYP_LOC100533290.1.1 m.9001 sp PARP1_CRIGR 52.264 1016 449 16 1 987 1 1009 0 1029 PARP1_CRIGR reviewed Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) PARP1 ADPRT Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 1013 "ATP generation from poly-ADP-D-ribose [GO:1990966]; cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; protein ADP-ribosylation [GO:0006471]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003950; GO:0005730; GO:0006302; GO:0006351; GO:0006355; GO:0006471; GO:0006974; GO:0008270; GO:0010613; GO:0051287; GO:1990966 0 0 0 PF00533;PF08063;PF00644;PF02877;PF05406;PF00645; Q9R1A8 CHOYP_RFWD2.1.1 m.51800 sp RFWD2_MOUSE 62.862 622 216 7 11 618 113 733 0 812 RFWD2_MOUSE reviewed E3 ubiquitin-protein ligase RFWD2 (EC 6.3.2.-) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1) (RING finger and WD repeat domain protein 2) Rfwd2 Cop1 Mus musculus (Mouse) 733 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; response to ionizing radiation [GO:0010212] GO:0000139; GO:0005654; GO:0005737; GO:0005813; GO:0005925; GO:0008270; GO:0010212; GO:0016607; GO:0016874; GO:0032436; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q9R1C7 CHOYP_BRAFLDRAFT_57552.1.1 m.8199 sp PR40A_MOUSE 46.237 837 327 10 120 861 145 953 0 607 PR40A_MOUSE reviewed Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 11) (FBP-11) (Formin-binding protein 3) Prpf40a Fbp11 Fnbp3 Mus musculus (Mouse) 953 "cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell shape [GO:0008360]; regulation of cytokinesis [GO:0032465]" GO:0000398; GO:0003723; GO:0005654; GO:0005685; GO:0005737; GO:0007010; GO:0008360; GO:0016020; GO:0016363; GO:0016477; GO:0016607; GO:0032465; GO:0044822; GO:0070064; GO:0071004 0 0 0 PF01846;PF00397; Q9R1K5 CHOYP_FZR.1.1 m.56638 sp FZR_MOUSE 75.4 500 107 10 1 491 1 493 0 734 FZR_MOUSE reviewed Fizzy-related protein homolog (Fzr) (Cdh1/Hct1 homolog) Fzr1 Fyr Fzr Mus musculus (Mouse) 493 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; DNA repair [GO:0006281]; G2 DNA damage checkpoint [GO:0031572]; lens fiber cell differentiation [GO:0070306]; mitotic nuclear division [GO:0007067]; negative regulation of cell aging [GO:0090344]; positive regulation of cell proliferation [GO:0008284]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein ubiquitination [GO:0016567]; regulation of meiotic nuclear division [GO:0040020] GO:0005654; GO:0005680; GO:0006281; GO:0007067; GO:0008284; GO:0016567; GO:0031145; GO:0031572; GO:0031965; GO:0040020; GO:0045732; GO:0051301; GO:0070306; GO:0090344; GO:0097027; GO:1904668 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12894;PF00400; Q9R1S3 CHOYP_PIGN.1.1 m.16281 sp PIGN_MOUSE 50.811 925 430 10 10 919 8 922 0 919 PIGN_MOUSE reviewed GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) Pign Mus musculus (Mouse) 931 GPI anchor biosynthetic process [GO:0006506] GO:0005789; GO:0006506; GO:0016020; GO:0016021; GO:0016780; GO:0051377 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF01663;PF04987; Q9R1S8 CHOYP_CAPN7.2.2 m.38888 sp CAN7_MOUSE 57.995 838 323 9 9 842 1 813 0 1013 CAN7_MOUSE reviewed Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH) Capn7 Palbh Mus musculus (Mouse) 813 positive regulation of epithelial cell migration [GO:0010634]; proteolysis [GO:0006508]; self proteolysis [GO:0097264] GO:0004175; GO:0004198; GO:0005654; GO:0005737; GO:0006508; GO:0010634; GO:0070062; GO:0090541; GO:0097264 0 0 0 PF01067;PF04212;PF00648; Q9R1X5 CHOYP_MRP5.2.3 m.24042 sp MRP5_MOUSE 38.641 1457 786 16 3 1408 28 1427 0 1040 MRP5_MOUSE reviewed Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) Abcc5 Abcc5a Mrp5 Mus musculus (Mouse) 1436 0 GO:0005524; GO:0008514; GO:0016020; GO:0016021; GO:0042626 0 0 0 PF00664;PF00005; Q9SB64 CHOYP_RCOM_1508680.1.1 m.25374 sp NBR1_ARATH 46.641 774 319 19 1 752 1 702 0 603 NBR1_ARATH reviewed Protein NBR1 homolog (AtNBR1) (At4g24690) NBR1 At4g24690 F22K18.110 Arabidopsis thaliana (Mouse-ear cress) 704 autophagy [GO:0006914]; protein polymerization [GO:0051258]; protein transport [GO:0015031] GO:0005737; GO:0005773; GO:0006914; GO:0008270; GO:0015031; GO:0043130; GO:0051258 0 0 cd14947; PF16158;PF00564;PF00569; Q9TT38 CHOYP_PA24A.1.3 m.13891 sp PA24A_RABIT 45.733 750 377 6 62 802 5 733 0 687 PA24A_RABIT reviewed Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 Oryctolagus cuniculus (Rabbit) 748 phospholipid catabolic process [GO:0009395] GO:0004622; GO:0004623; GO:0005509; GO:0005544; GO:0009395; GO:0016023 0 0 0 PF00168;PF01735; Q9TZM3 CHOYP_PHUM_PHUM346120.1.1 m.51896 sp LRK1_CAEEL 28.624 2463 1458 70 11 2376 29 2288 0 800 LRK1_CAEEL reviewed "Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1) (Leucine-rich repeats, ras-like domain, kinase protein 1) (PARK8-related kinase)" lrk-1 T27C10.6 Caenorhabditis elegans 2393 axon extension involved in axon guidance [GO:0048846]; cellular protein localization [GO:0034613]; negative regulation of neuron death [GO:1901215]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle transport [GO:0048489] GO:0004674; GO:0005524; GO:0005525; GO:0005737; GO:0005794; GO:0006979; GO:0007264; GO:0034613; GO:0034976; GO:0043025; GO:0046872; GO:0048489; GO:0048846; GO:1901215 0 0 0 PF12796;PF16095;PF13855;PF00069;PF08477; Q9U2C4 CHOYP_GALT9.1.1 m.10091 sp GALT9_CAEEL 48.969 582 267 12 1 561 1 573 0 537 GALT9_CAEEL reviewed Probable N-acetylgalactosaminyltransferase 9 (EC 2.4.1.-) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9) (pp-GaNTase 9) gly-9 Y47D3A.23 Caenorhabditis elegans 579 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0016021; GO:0016757; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q9U518 CHOYP_CPIPJ_CPIJ008683.1.1 m.50615 sp ASPG_DIRIM 47.483 596 301 5 51 645 6 590 0 545 ASPG_DIRIM reviewed L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) 0 Dirofilaria immitis (Canine heartworm) 590 asparagine metabolic process [GO:0006528] GO:0004067; GO:0006528 0 0 0 PF00710; Q9U518 CHOYP_DVIR_GJ15882.1.1 m.3103 sp ASPG_DIRIM 47.635 592 300 7 33 619 4 590 0 531 ASPG_DIRIM reviewed L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) 0 Dirofilaria immitis (Canine heartworm) 590 asparagine metabolic process [GO:0006528] GO:0004067; GO:0006528 0 0 0 PF00710; Q9U518 CHOYP_LOC100702209.1.1 m.55473 sp ASPG_DIRIM 47.906 597 300 7 19 611 1 590 0 536 ASPG_DIRIM reviewed L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) 0 Dirofilaria immitis (Canine heartworm) 590 asparagine metabolic process [GO:0006528] GO:0004067; GO:0006528 0 0 0 PF00710; Q9U639 CHOYP_HSP7D.2.3 m.34782 sp HSP7D_MANSE 89.198 611 62 1 8 618 6 612 0 1136 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9UBH6 CHOYP_LOC101159134.1.1 m.60947 sp XPR1_HUMAN 60.03 663 244 8 1 653 1 652 0 811 XPR1_HUMAN reviewed Xenotropic and polytropic retrovirus receptor 1 (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) XPR1 SYG1 XR Homo sapiens (Human) 696 cellular phosphate ion homeostasis [GO:0030643]; G-protein coupled receptor signaling pathway [GO:0007186]; phosphate ion transmembrane transport [GO:0035435]; response to virus [GO:0009615] GO:0000822; GO:0001618; GO:0004872; GO:0004888; GO:0004930; GO:0005794; GO:0007186; GO:0009615; GO:0015114; GO:0015562; GO:0016021; GO:0030643; GO:0031226; GO:0035435 0 0 0 PF03124;PF03105; Q9UBJ2 CHOYP_LOC100373129.1.1 m.7859 sp ABCD2_HUMAN 66.464 659 211 4 74 727 77 730 0 903 ABCD2_HUMAN reviewed ATP-binding cassette sub-family D member 2 (Adrenoleukodystrophy-like 1) (Adrenoleukodystrophy-related protein) (hALDR) ABCD2 ALD1 ALDL1 ALDR ALDRP Homo sapiens (Human) 740 fatty acid beta-oxidation [GO:0006635]; positive regulation of fatty acid beta-oxidation [GO:0032000]; transmembrane transport [GO:0055085]; very long-chain fatty acid catabolic process [GO:0042760]; very long-chain fatty acid metabolic process [GO:0000038] GO:0000038; GO:0005324; GO:0005524; GO:0005777; GO:0005778; GO:0005829; GO:0006635; GO:0016021; GO:0032000; GO:0042626; GO:0042760; GO:0042803; GO:0043231; GO:0055085 0 0 0 PF06472;PF00005; Q9UBL3 CHOYP_AAK1.1.1 m.14769 sp ASH2L_HUMAN 53.43 554 233 10 18 557 75 617 0 565 ASH2L_HUMAN reviewed Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) ASH2L ASH2L1 Homo sapiens (Human) 628 "beta-catenin-TCF complex assembly [GO:1904837]; cellular response to DNA damage stimulus [GO:0006974]; hemopoiesis [GO:0030097]; histone H3-K4 methylation [GO:0051568]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to estrogen [GO:0043627]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003677; GO:0005634; GO:0005654; GO:0005719; GO:0006351; GO:0006355; GO:0006366; GO:0006974; GO:0008013; GO:0008284; GO:0018024; GO:0030097; GO:0035097; GO:0043627; GO:0044212; GO:0044666; GO:0045944; GO:0046872; GO:0048188; GO:0051568; GO:0071339; GO:1904837; GO:1990188 0 0 0 PF00622; Q9UBN7 CHOYP_LOC100877749.1.1 m.65236 sp HDAC6_HUMAN 41.847 877 471 7 89 963 79 918 0 722 HDAC6_HUMAN reviewed Histone deacetylase 6 (HD6) (EC 3.5.1.98) HDAC6 KIAA0901 JM21 Homo sapiens (Human) 1215 "aggresome assembly [GO:0070842]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to topologically incorrect protein [GO:0035967]; histone deacetylation [GO:0016575]; Hsp90 deacetylation [GO:0070846]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; macroautophagy [GO:0016236]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrion localization [GO:0051646]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; negative regulation of transcription, DNA-templated [GO:0045892]; organelle organization [GO:0006996]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of receptor biosynthetic process [GO:0010870]; positive regulation of signal transduction [GO:0009967]; protein complex disassembly [GO:0043241]; protein deacetylation [GO:0006476]; protein polyubiquitination [GO:0000209]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression, epigenetic [GO:0040029]; regulation of microtubule-based movement [GO:0060632]; regulation of mitophagy [GO:1903146]; regulation of protein stability [GO:0031647]; regulation of receptor activity [GO:0010469]; response to growth factor [GO:0070848]; response to misfolded protein [GO:0051788]; response to organic substance [GO:0010033]; response to toxic substance [GO:0009636]; transcription, DNA-templated [GO:0006351]; tubulin deacetylation [GO:0090042]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]" GO:0000118; GO:0000209; GO:0001047; GO:0004407; GO:0005634; GO:0005737; GO:0005771; GO:0005829; GO:0005874; GO:0005875; GO:0005881; GO:0005901; GO:0006351; GO:0006476; GO:0006515; GO:0006886; GO:0006996; GO:0007026; GO:0008013; GO:0008017; GO:0008270; GO:0009636; GO:0009967; GO:0010033; GO:0010469; GO:0010506; GO:0010634; GO:0010727; GO:0010870; GO:0016234; GO:0016235; GO:0016236; GO:0016575; GO:0019899; GO:0030424; GO:0030425; GO:0031252; GO:0031593; GO:0031625; GO:0031647; GO:0032041; GO:0032418; GO:0034983; GO:0035967; GO:0040029; GO:0042826; GO:0042903; GO:0043014; GO:0043162; GO:0043204; GO:0043241; GO:0043242; GO:0045598; GO:0045861; GO:0045892; GO:0048156; GO:0048471; GO:0051354; GO:0051646; GO:0051787; GO:0051788; GO:0051879; GO:0060632; GO:0060765; GO:0070201; GO:0070301; GO:0070840; GO:0070842; GO:0070845; GO:0070846; GO:0070848; GO:0071218; GO:0090035; GO:0090042; GO:0098779; GO:1901300; GO:1903146 0 0 0 PF00850;PF02148; Q9UBN7 CHOYP_PHUM_PHUM538580.1.1 m.43268 sp HDAC6_HUMAN 40.786 814 444 7 7 814 79 860 0 629 HDAC6_HUMAN reviewed Histone deacetylase 6 (HD6) (EC 3.5.1.98) HDAC6 KIAA0901 JM21 Homo sapiens (Human) 1215 "aggresome assembly [GO:0070842]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to topologically incorrect protein [GO:0035967]; histone deacetylation [GO:0016575]; Hsp90 deacetylation [GO:0070846]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; macroautophagy [GO:0016236]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrion localization [GO:0051646]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; negative regulation of transcription, DNA-templated [GO:0045892]; organelle organization [GO:0006996]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of receptor biosynthetic process [GO:0010870]; positive regulation of signal transduction [GO:0009967]; protein complex disassembly [GO:0043241]; protein deacetylation [GO:0006476]; protein polyubiquitination [GO:0000209]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of autophagy [GO:0010506]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression, epigenetic [GO:0040029]; regulation of microtubule-based movement [GO:0060632]; regulation of mitophagy [GO:1903146]; regulation of protein stability [GO:0031647]; regulation of receptor activity [GO:0010469]; response to growth factor [GO:0070848]; response to misfolded protein [GO:0051788]; response to organic substance [GO:0010033]; response to toxic substance [GO:0009636]; transcription, DNA-templated [GO:0006351]; tubulin deacetylation [GO:0090042]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]" GO:0000118; GO:0000209; GO:0001047; GO:0004407; GO:0005634; GO:0005737; GO:0005771; GO:0005829; GO:0005874; GO:0005875; GO:0005881; GO:0005901; GO:0006351; GO:0006476; GO:0006515; GO:0006886; GO:0006996; GO:0007026; GO:0008013; GO:0008017; GO:0008270; GO:0009636; GO:0009967; GO:0010033; GO:0010469; GO:0010506; GO:0010634; GO:0010727; GO:0010870; GO:0016234; GO:0016235; GO:0016236; GO:0016575; GO:0019899; GO:0030424; GO:0030425; GO:0031252; GO:0031593; GO:0031625; GO:0031647; GO:0032041; GO:0032418; GO:0034983; GO:0035967; GO:0040029; GO:0042826; GO:0042903; GO:0043014; GO:0043162; GO:0043204; GO:0043241; GO:0043242; GO:0045598; GO:0045861; GO:0045892; GO:0048156; GO:0048471; GO:0051354; GO:0051646; GO:0051787; GO:0051788; GO:0051879; GO:0060632; GO:0060765; GO:0070201; GO:0070301; GO:0070840; GO:0070842; GO:0070845; GO:0070846; GO:0070848; GO:0071218; GO:0090035; GO:0090042; GO:0098779; GO:1901300; GO:1903146 0 0 0 PF00850;PF02148; Q9UBR1 CHOYP_BUP1.1.1 m.13641 sp BUP1_HUMAN 69.792 384 115 1 1 383 1 384 0 579 BUP1_HUMAN reviewed Beta-ureidopropionase (EC 3.5.1.6) (BUP-1) (Beta-alanine synthase) (N-carbamoyl-beta-alanine amidohydrolase) UPB1 BUP1 Homo sapiens (Human) 384 beta-alanine biosynthetic process [GO:0019483]; pyrimidine nucleoside catabolic process [GO:0046135] GO:0003837; GO:0005829; GO:0019483; GO:0046135; GO:0046872; GO:0070062 PATHWAY: Amino-acid biosynthesis; beta-alanine biosynthesis. 0 0 PF00795; Q9UBV2 CHOYP_BRAFLDRAFT_220356.2.6 m.7935 sp SE1L1_HUMAN 62.416 596 217 4 293 884 171 763 0 765 SE1L1_HUMAN reviewed Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) 794 "endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" GO:0000836; GO:0000839; GO:0005783; GO:0005789; GO:0006641; GO:0007219; GO:0009306; GO:0016021; GO:0030433; GO:0030970; GO:0036503; GO:0036513; GO:0044322; GO:0050821; GO:1904380 0 0 cd00062; PF00040;PF08238; Q9UBV2 CHOYP_BRAFLDRAFT_220356.3.6 m.11117 sp SE1L1_HUMAN 62.416 596 217 4 273 864 171 763 0 766 SE1L1_HUMAN reviewed Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) 794 "endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" GO:0000836; GO:0000839; GO:0005783; GO:0005789; GO:0006641; GO:0007219; GO:0009306; GO:0016021; GO:0030433; GO:0030970; GO:0036503; GO:0036513; GO:0044322; GO:0050821; GO:1904380 0 0 cd00062; PF00040;PF08238; Q9UBV2 CHOYP_BRAFLDRAFT_220356.4.6 m.16943 sp SE1L1_HUMAN 62.416 596 217 4 520 1111 171 763 0 769 SE1L1_HUMAN reviewed Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) 794 "endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" GO:0000836; GO:0000839; GO:0005783; GO:0005789; GO:0006641; GO:0007219; GO:0009306; GO:0016021; GO:0030433; GO:0030970; GO:0036503; GO:0036513; GO:0044322; GO:0050821; GO:1904380 0 0 cd00062; PF00040;PF08238; Q9UBV2 CHOYP_BRAFLDRAFT_220356.5.6 m.38506 sp SE1L1_HUMAN 62.752 596 215 4 62 653 171 763 0 760 SE1L1_HUMAN reviewed Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) 794 "endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" GO:0000836; GO:0000839; GO:0005783; GO:0005789; GO:0006641; GO:0007219; GO:0009306; GO:0016021; GO:0030433; GO:0030970; GO:0036503; GO:0036513; GO:0044322; GO:0050821; GO:1904380 0 0 cd00062; PF00040;PF08238; Q9UBV2 CHOYP_BRAFLDRAFT_220356.6.6 m.65710 sp SE1L1_HUMAN 62.752 596 215 4 306 897 171 763 0 767 SE1L1_HUMAN reviewed Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) 794 "endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" GO:0000836; GO:0000839; GO:0005783; GO:0005789; GO:0006641; GO:0007219; GO:0009306; GO:0016021; GO:0030433; GO:0030970; GO:0036503; GO:0036513; GO:0044322; GO:0050821; GO:1904380 0 0 cd00062; PF00040;PF08238; Q9UDR5 CHOYP_LOC100123521.2.2 m.52492 sp AASS_HUMAN 53.385 901 410 5 49 945 23 917 0 997 AASS_HUMAN reviewed "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Homo sapiens (Human) 926 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine catabolic process [GO:0006554]; protein tetramerization [GO:0051262] GO:0005739; GO:0005759; GO:0006554; GO:0033512; GO:0043231; GO:0047130; GO:0047131; GO:0051262 PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.; PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. 0 0 PF05222;PF16653;PF03435; Q9UEW8 CHOYP_ISCW_ISCW022925.1.2 m.61535 sp STK39_HUMAN 60.687 524 169 6 23 543 56 545 0 631 STK39_HUMAN reviewed STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) STK39 SPAK Homo sapiens (Human) 545 cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; negative regulation of rubidium ion transport [GO:2000681]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of potassium ion transport [GO:0043268]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of ion homeostasis [GO:2000021]; response to stress [GO:0006950]; signal transduction by protein phosphorylation [GO:0023014] GO:0001933; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0005856; GO:0006468; GO:0006950; GO:0008217; GO:0016323; GO:0016324; GO:0018105; GO:0018107; GO:0023014; GO:0035556; GO:0043268; GO:0050727; GO:0071476; GO:0090188; GO:1901017; GO:1901380; GO:2000021; GO:2000681; GO:2000687 0 0 0 PF12202;PF00069; Q9UGJ1 CHOYP_GCP4.1.1 m.7700 sp GCP4_HUMAN 51.724 667 303 7 1 652 1 663 0 667 GCP4_HUMAN reviewed Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) TUBGCP4 76P GCP4 Homo sapiens (Human) 667 centrosome duplication [GO:0051298]; cytoplasmic microtubule organization [GO:0031122]; interphase microtubule nucleation by interphase microtubule organizing center [GO:0051415]; meiotic nuclear division [GO:0007126]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307]; protein complex assembly [GO:0006461] GO:0000923; GO:0000930; GO:0005200; GO:0005813; GO:0005816; GO:0005829; GO:0005874; GO:0006461; GO:0007020; GO:0007126; GO:0008274; GO:0015630; GO:0016020; GO:0031122; GO:0043015; GO:0051298; GO:0051415; GO:0055037; GO:0090307 0 0 0 PF04130; Q9UGM3 CHOYP_DMBT1.29.34 m.58099 sp DMBT1_HUMAN 40.337 1009 435 21 1 851 244 1243 0 671 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UGM3 CHOYP_DMBT1.31.34 m.58282 sp DMBT1_HUMAN 39.201 1653 714 29 28 1402 100 1739 0 1044 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UGM3 CHOYP_DMBT1.9.34 m.18470 sp DMBT1_HUMAN 43.246 881 385 18 28 813 363 1223 0 644 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UGM3 CHOYP_LOC100636340.1.4 m.5143 sp DMBT1_HUMAN 39.302 1949 861 45 248 1920 98 2000 0 1174 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UGM3 CHOYP_LOC100636340.2.4 m.41214 sp DMBT1_HUMAN 33.064 1609 741 35 321 1616 4 1589 0 719 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UGM3 CHOYP_LOC100636340.4.4 m.50991 sp DMBT1_HUMAN 37.782 1903 851 41 229 1815 100 1985 0 1104 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UGM3 CHOYP_LOC757057.3.5 m.48154 sp DMBT1_HUMAN 34.754 1525 685 35 456 1689 216 1721 0 736 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UHB4 CHOYP_BRAFLDRAFT_122922.1.1 m.17746 sp NDOR1_HUMAN 56.146 602 251 3 1 594 1 597 0 675 NDOR1_HUMAN reviewed NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1) NDOR1 NR1 Homo sapiens (Human) 597 cell death [GO:0008219]; cellular response to menadione [GO:0036245]; iron-sulfur cluster assembly [GO:0016226]; oxidation-reduction process [GO:0055114] GO:0003958; GO:0005634; GO:0005737; GO:0005829; GO:0008219; GO:0010181; GO:0016226; GO:0016491; GO:0036245; GO:0045111; GO:0048471; GO:0050660; GO:0050661; GO:0055114 0 0 0 PF00667;PF00258;PF00175; Q9UHB9 CHOYP_SRP68.1.1 m.61852 sp SRP68_HUMAN 52.159 579 255 9 53 623 57 621 0 575 SRP68_HUMAN reviewed Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein) SRP68 Homo sapiens (Human) 627 protein targeting to ER [GO:0045047]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005047; GO:0005730; GO:0005737; GO:0005783; GO:0005786; GO:0005829; GO:0005840; GO:0005925; GO:0006614; GO:0008312; GO:0030942; GO:0042493; GO:0044822; GO:0045047 0 0 0 PF16969; Q9UHJ3 CHOYP_BRAFLDRAFT_226942.1.1 m.49751 sp SMBT1_HUMAN 44.954 872 426 15 346 1188 19 865 0 696 SMBT1_HUMAN reviewed Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1) SFMBT1 RU1 Homo sapiens (Human) 866 "cell differentiation [GO:0030154]; covalent chromatin modification [GO:0016569]; negative regulation of muscle organ development [GO:0048635]; negative regulation of transcription, DNA-templated [GO:0045892]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003714; GO:0005634; GO:0005654; GO:0006351; GO:0007283; GO:0016569; GO:0030154; GO:0042393; GO:0045892; GO:0048635 0 0 0 PF02820;PF00536;PF12140; Q9UHX1 CHOYP_LOC100367069.1.1 m.14484 sp PUF60_HUMAN 56.624 551 167 8 92 618 56 558 0 539 PUF60_HUMAN reviewed Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1) PUF60 FIR ROBPI SIAHBP1 Homo sapiens (Human) 559 "apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0005654; GO:0005913; GO:0006351; GO:0006355; GO:0006397; GO:0006915; GO:0008380; GO:0030054; GO:0030529; GO:0042802; GO:0044822; GO:0098641 0 0 0 PF00076; Q9UI40 CHOYP_NCKX2.1.1 m.56696 sp NCKX2_HUMAN 47.496 659 261 11 7 607 30 661 0 565 NCKX2_HUMAN reviewed Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2) SLC24A2 NCKX2 Homo sapiens (Human) 661 cellular calcium ion homeostasis [GO:0006874]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; learning [GO:0007612]; long term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005262; GO:0005509; GO:0005886; GO:0005887; GO:0006811; GO:0006874; GO:0007601; GO:0007612; GO:0007613; GO:0008273; GO:0015293; GO:0016151; GO:0030145; GO:0030955; GO:0031402; GO:0034220; GO:0046870; GO:0050896; GO:0060291; GO:0060292 0 0 0 PF01699; Q9UIG0 CHOYP_BAZ1B.1.1 m.24480 sp BAZ1B_HUMAN 39.618 1310 632 28 2 1219 3 1245 0 850 BAZ1B_HUMAN reviewed Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) BAZ1B WBSC10 WBSCR10 WBSCR9 WSTF Homo sapiens (Human) 1483 "cellular response to DNA damage stimulus [GO:0006974]; chromatin assembly or disassembly [GO:0006333]; chromatin-mediated maintenance of transcription [GO:0048096]; double-strand break repair [GO:0006302]; heart morphogenesis [GO:0003007]; histone phosphorylation [GO:0016572]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000793; GO:0003007; GO:0003682; GO:0004713; GO:0004715; GO:0005524; GO:0005654; GO:0005721; GO:0006302; GO:0006333; GO:0006351; GO:0006355; GO:0006974; GO:0008270; GO:0016572; GO:0035173; GO:0045815; GO:0048096; GO:0070577; GO:0071884 0 0 0 PF00439;PF00628;PF10537;PF15612;PF15613; Q9UJ83 CHOYP_HACL1.1.1 m.6578 sp HACL1_HUMAN 59.13 575 232 2 5 578 6 578 0 735 HACL1_HUMAN reviewed 2-hydroxyacyl-CoA lyase 1 (EC 4.1.-.-) (2-hydroxyphytanoyl-CoA lyase) (2-HPCL) (Phytanoyl-CoA 2-hydroxylase 2) HACL1 HPCL HPCL2 PHYH2 HSPC279 Homo sapiens (Human) 578 fatty acid alpha-oxidation [GO:0001561]; protein oligomerization [GO:0051259] GO:0000287; GO:0001561; GO:0005102; GO:0005777; GO:0005782; GO:0016830; GO:0030976; GO:0042802; GO:0048037; GO:0051259 PATHWAY: Lipid metabolism; fatty acid metabolism. 0 0 PF02775;PF00205;PF02776; Q9UJX6 CHOYP_LOC100650613.1.1 m.10270 sp ANC2_HUMAN 44.387 775 393 11 5 746 51 820 0 653 ANC2_HUMAN reviewed Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2) ANAPC2 APC2 KIAA1406 Homo sapiens (Human) 822 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005654; GO:0005680; GO:0005829; GO:0007067; GO:0031145; GO:0031625; GO:0031915; GO:0042787; GO:0043161; GO:0045773; GO:0050775; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0070979; GO:0090129 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF08672;PF00888; Q9UKG1 CHOYP_DP13A.2.3 m.10746 sp DP13A_HUMAN 42.031 709 381 12 2 690 3 701 0 536 DP13A_HUMAN reviewed "DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)" APPL1 APPL DIP13A KIAA1428 Homo sapiens (Human) 709 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; insulin receptor signaling pathway [GO:0008286]; regulation of establishment of protein localization to plasma membrane [GO:0090003]; regulation of glucose import [GO:0046324]; signal transduction [GO:0007165] GO:0005634; GO:0005737; GO:0005829; GO:0007049; GO:0007165; GO:0008283; GO:0008286; GO:0010008; GO:0012506; GO:0031901; GO:0042802; GO:0043422; GO:0046324; GO:0070062; GO:0090003; GO:0097192 0 0 0 PF00169;PF00640; Q9UKG9 CHOYP_OCTC.1.1 m.31819 sp OCTC_HUMAN 46.88 593 308 4 13 601 5 594 0 568 OCTC_HUMAN reviewed Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) CROT COT Homo sapiens (Human) 612 carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791]; response to drug [GO:0042493]; response to organonitrogen compound [GO:0010243] GO:0005102; GO:0005739; GO:0005777; GO:0005782; GO:0006091; GO:0006631; GO:0006635; GO:0008458; GO:0009437; GO:0010243; GO:0015908; GO:0015936; GO:0033540; GO:0042493; GO:0043231; GO:0051791 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00755; Q9UKI8 CHOYP_LOC100870649.1.2 m.13573 sp TLK1_HUMAN 57.022 712 239 13 7 670 52 744 0 712 TLK1_HUMAN reviewed Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) TLK1 KIAA0137 Homo sapiens (Human) 766 cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; covalent chromatin modification [GO:0016569]; intracellular protein transport [GO:0006886]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of chromatin assembly or disassembly [GO:0001672] GO:0001672; GO:0004674; GO:0005524; GO:0005634; GO:0006468; GO:0006886; GO:0006974; GO:0007049; GO:0016569; GO:0035556 0 0 0 PF00069; Q9UKI8 CHOYP_LOC100870649.2.2 m.42954 sp TLK1_HUMAN 56.259 711 220 13 7 644 52 744 0 708 TLK1_HUMAN reviewed Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) TLK1 KIAA0137 Homo sapiens (Human) 766 cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; covalent chromatin modification [GO:0016569]; intracellular protein transport [GO:0006886]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of chromatin assembly or disassembly [GO:0001672] GO:0001672; GO:0004674; GO:0005524; GO:0005634; GO:0006468; GO:0006886; GO:0006974; GO:0007049; GO:0016569; GO:0035556 0 0 0 PF00069; Q9UKK3 CHOYP_LOC100373327.1.13 m.13252 sp PARP4_HUMAN 37.023 1310 744 28 3 1277 4 1267 0 787 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKK3 CHOYP_LOC100373327.10.13 m.43864 sp PARP4_HUMAN 38.25 1234 715 23 1 1210 1 1211 0 793 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKK3 CHOYP_LOC100373327.12.13 m.64673 sp PARP4_HUMAN 36.87 1310 746 28 3 1277 4 1267 0 785 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKK3 CHOYP_LOC100373327.13.13 m.66457 sp PARP4_HUMAN 42.742 992 541 15 42 1019 233 1211 0 777 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKK3 CHOYP_LOC100373327.2.13 m.16978 sp PARP4_HUMAN 37.143 1260 720 26 1 1226 2 1223 0 775 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKK3 CHOYP_LOC100373327.6.13 m.32009 sp PARP4_HUMAN 38.3 1235 713 24 1 1210 1 1211 0 793 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKK3 CHOYP_LOC100373327.9.13 m.43531 sp PARP4_HUMAN 37.023 1310 744 28 3 1277 4 1267 0 788 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKK3 CHOYP_PARP4.2.2 m.16326 sp PARP4_HUMAN 45.309 874 459 12 1 862 345 1211 0 739 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UKN7 CHOYP_MYO15.1.1 m.66281 sp MYO15_HUMAN 44.18 1177 612 14 9 1176 1220 2360 0 1021 MYO15_HUMAN reviewed Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) 3530 inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0007626; GO:0016459; GO:0032420; GO:0042472; GO:0070062 0 0 0 PF00373;PF00612;PF00063;PF00784;PF07653; Q9UKN7 CHOYP_PHUM_PHUM430580.1.1 m.61591 sp MYO15_HUMAN 44.18 1177 612 14 9 1176 1220 2360 0 1021 MYO15_HUMAN reviewed Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) 3530 inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0007626; GO:0016459; GO:0032420; GO:0042472; GO:0070062 0 0 0 PF00373;PF00612;PF00063;PF00784;PF07653; Q9UKP4 CHOYP_BRAFLDRAFT_85817.1.1 m.34013 sp ATS7_HUMAN 45.427 973 503 15 46 1007 44 999 0 899 ATS7_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) ADAMTS7 Homo sapiens (Human) 1686 cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of chondrocyte differentiation [GO:0032331]; protein O-linked fucosylation [GO:0036066]; proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004222; GO:0005578; GO:0005788; GO:0008237; GO:0008270; GO:0009986; GO:0032331; GO:0036066; GO:0051603; GO:0071347; GO:0071356; GO:0071773; GO:0098779 0 0 0 PF05986;PF01562;PF01421;PF00090; Q9UKP5 CHOYP_ATS6.2.3 m.30004 sp ATS6_HUMAN 47.128 679 353 6 2 676 439 1115 0 655 ATS6_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-) ADAMTS6 Homo sapiens (Human) 1117 aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976] GO:0003279; GO:0004222; GO:0005578; GO:0008237; GO:0008270; GO:0035904; GO:0060976 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q9UKZ1 CHOYP_LOC100367053.1.1 m.18595 sp CNO11_HUMAN 64.444 450 145 5 1 444 61 501 0 596 CNO11_HUMAN reviewed CCR4-NOT transcription complex subunit 11 CNOT11 C2orf29 C40 Homo sapiens (Human) 510 "cell proliferation [GO:0008283]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; gene silencing by RNA [GO:0031047]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000289; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0006417; GO:0006977; GO:0008283; GO:0030014; GO:0031047 0 0 0 PF10155; Q9ULB1 CHOYP_LOC100856796.2.3 m.36646 sp NRX1A_HUMAN 34.806 1494 833 35 24 1445 29 1453 0 850 NRX1A_HUMAN reviewed Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 KIAA0578 Homo sapiens (Human) 1477 "adult behavior [GO:0030534]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; learning [GO:0007612]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; prepulse inhibition [GO:0060134]; regulation of grooming behavior [GO:2000821]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]; vocal learning [GO:0042297]" GO:0004872; GO:0005246; GO:0005509; GO:0005783; GO:0005886; GO:0005887; GO:0007158; GO:0007268; GO:0007269; GO:0007411; GO:0007416; GO:0007612; GO:0009986; GO:0030054; GO:0030534; GO:0031965; GO:0031982; GO:0033130; GO:0035176; GO:0042297; GO:0042734; GO:0043025; GO:0043234; GO:0050839; GO:0050885; GO:0051965; GO:0051968; GO:0060134; GO:0061178; GO:0071625; GO:0090129; GO:0097104; GO:0097109; GO:0097116; GO:0097118; GO:0097119; GO:2000463; GO:2000821 0 0 0 PF00008;PF02210;PF01034; Q9ULB1 CHOYP_LOC100856796.3.3 m.37215 sp NRX1A_HUMAN 34.188 1521 833 35 24 1472 29 1453 0 843 NRX1A_HUMAN reviewed Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 KIAA0578 Homo sapiens (Human) 1477 "adult behavior [GO:0030534]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; learning [GO:0007612]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; prepulse inhibition [GO:0060134]; regulation of grooming behavior [GO:2000821]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]; vocal learning [GO:0042297]" GO:0004872; GO:0005246; GO:0005509; GO:0005783; GO:0005886; GO:0005887; GO:0007158; GO:0007268; GO:0007269; GO:0007411; GO:0007416; GO:0007612; GO:0009986; GO:0030054; GO:0030534; GO:0031965; GO:0031982; GO:0033130; GO:0035176; GO:0042297; GO:0042734; GO:0043025; GO:0043234; GO:0050839; GO:0050885; GO:0051965; GO:0051968; GO:0060134; GO:0061178; GO:0071625; GO:0090129; GO:0097104; GO:0097109; GO:0097116; GO:0097118; GO:0097119; GO:2000463; GO:2000821 0 0 0 PF00008;PF02210;PF01034; Q9ULC5 CHOYP_BRAFLDRAFT_120586.1.1 m.41856 sp ACSL5_HUMAN 51.351 666 318 5 20 682 16 678 0 710 ACSL5_HUMAN reviewed Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5) ACSL5 ACS5 FACL5 UNQ633/PRO1250 Homo sapiens (Human) 683 long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; regulation of extrinsic apoptotic signaling pathway [GO:2001236] GO:0001676; GO:0004467; GO:0005524; GO:0005634; GO:0005730; GO:0005739; GO:0005741; GO:0005743; GO:0005783; GO:0005789; GO:0016020; GO:0016021; GO:0035338; GO:0102391; GO:2001236 0 0 0 PF00501; Q9ULG1 CHOYP_INO80.1.2 m.1270 sp INO80_HUMAN 51.457 1510 531 32 13 1392 15 1452 0 1395 INO80_HUMAN reviewed DNA helicase INO80 (hINO80) (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1) INO80 INO80A INOC1 KIAA1259 Homo sapiens (Human) 1556 "cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of cell growth [GO:0030307]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; spindle assembly [GO:0051225]; transcription, DNA-templated [GO:0006351]; UV-damage excision repair [GO:0070914]" GO:0000070; GO:0000724; GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0005874; GO:0006302; GO:0006338; GO:0006351; GO:0010571; GO:0016887; GO:0030307; GO:0031011; GO:0034644; GO:0043014; GO:0045944; GO:0051225; GO:0051301; GO:0070914; GO:0071479; GO:2000045 0 0 0 PF13892;PF00271;PF00176; Q9ULI0 CHOYP_ATD2B.1.1 m.45160 sp ATD2B_HUMAN 53.814 970 380 13 9 958 165 1086 0 984 ATD2B_HUMAN reviewed ATPase family AAA domain-containing protein 2B ATAD2B KIAA1240 Homo sapiens (Human) 1458 negative regulation of chromatin silencing [GO:0031936]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003682; GO:0005524; GO:0005634; GO:0016887; GO:0031936; GO:0045944; GO:0070577 0 0 0 PF00004;PF00439; Q9ULJ6 CHOYP_BRAFLDRAFT_130685.1.1 m.63499 sp ZMIZ1_HUMAN 45.844 1143 427 31 1 1029 1 1065 0 729 ZMIZ1_HUMAN reviewed Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17) ZMIZ1 KIAA1224 RAI17 ZIMP10 Homo sapiens (Human) 1067 "artery morphogenesis [GO:0048844]; cell aging [GO:0007569]; developmental growth [GO:0048589]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]; vasculogenesis [GO:0001570]; vitellogenesis [GO:0007296]" GO:0001570; GO:0001701; GO:0003007; GO:0005654; GO:0005737; GO:0006351; GO:0007296; GO:0007569; GO:0008270; GO:0016607; GO:0043231; GO:0045944; GO:0048146; GO:0048589; GO:0048844 0 0 0 PF02891; Q9ULJ7 CHOYP_LOC100369716.1.1 m.63159 sp ANR50_HUMAN 52.74 1405 543 18 4 1327 16 1380 0 1363 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9ULT8 CHOYP_HECD1.1.1 m.27759 sp HECD1_HUMAN 69.75 1362 382 12 1 1353 1 1341 0 1969 HECD1_HUMAN reviewed E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1) HECTD1 KIAA1131 Homo sapiens (Human) 2610 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005737; GO:0016874; GO:0042787; GO:0046872 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF00632;PF06701;PF07738; Q9ULV1 CHOYP_FZD4.1.1 m.39805 sp FZD4_HUMAN 60.12 499 178 6 25 516 38 522 0 631 FZD4_HUMAN reviewed Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344) FZD4 Homo sapiens (Human) 537 "canonical Wnt signaling pathway [GO:0060070]; cellular response to retinoic acid [GO:0071300]; cerebellum vasculature morphogenesis [GO:0061301]; extracellular matrix-cell signaling [GO:0035426]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of cell-substrate adhesion [GO:0010812]; neuron differentiation [GO:0030182]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; progesterone secretion [GO:0042701]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; retinal blood vessel morphogenesis [GO:0061304]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; sensory perception of sound [GO:0007605]; substrate adhesion-dependent cell spreading [GO:0034446]; vasculogenesis [GO:0001570]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0001570; GO:0004930; GO:0005886; GO:0005887; GO:0005911; GO:0007223; GO:0007605; GO:0009986; GO:0010812; GO:0016021; GO:0016055; GO:0017147; GO:0019955; GO:0030165; GO:0030182; GO:0030669; GO:0030947; GO:0031625; GO:0031987; GO:0034446; GO:0035426; GO:0042701; GO:0042803; GO:0042813; GO:0043507; GO:0045893; GO:0046982; GO:0051091; GO:0060070; GO:0060071; GO:0061299; GO:0061301; GO:0061304; GO:0070062; GO:0071300 0 0 0 PF01534;PF01392; Q9UM54 CHOYP_MYO6.1.1 m.4131 sp MYO6_HUMAN 59.297 1280 467 10 1 1233 1 1273 0 1485 MYO6_HUMAN reviewed Unconventional myosin-VI (Unconventional myosin-6) MYO6 KIAA0389 Homo sapiens (Human) 1294 "actin filament-based movement [GO:0030048]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of secretion [GO:0051046]; response to drug [GO:0042493]; sensory perception of sound [GO:0007605]" GO:0001726; GO:0003774; GO:0003779; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005765; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0005905; GO:0005913; GO:0005938; GO:0006886; GO:0006897; GO:0007605; GO:0016020; GO:0016023; GO:0016461; GO:0016591; GO:0030048; GO:0030139; GO:0030330; GO:0030665; GO:0031941; GO:0031965; GO:0032587; GO:0042493; GO:0043531; GO:0045177; GO:0045944; GO:0048471; GO:0051015; GO:0051046; GO:0060001; GO:0070062; GO:0098641 0 0 0 PF16521;PF00063; Q9UNH5 CHOYP_CDC14A.1.1 m.18068 sp CC14A_HUMAN 63.692 493 155 8 2 490 3 475 0 650 CC14A_HUMAN reviewed Dual specificity protein phosphatase CDC14A (EC 3.1.3.16) (EC 3.1.3.48) (CDC14 cell division cycle 14 homolog A) CDC14A Homo sapiens (Human) 594 cell division [GO:0051301]; cell proliferation [GO:0008283]; cilium assembly [GO:0042384]; mitotic cell cycle arrest [GO:0071850]; mitotic spindle midzone assembly [GO:0051256]; regulation of exit from mitosis [GO:0007096] GO:0000922; GO:0004721; GO:0004722; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0007096; GO:0008138; GO:0008283; GO:0042384; GO:0051256; GO:0051301; GO:0071850; GO:0072686 0 0 0 PF00782;PF14671; Q9UNH7 CHOYP_BRAFLDRAFT_77132.1.2 m.5217 sp SNX6_HUMAN 67.327 404 129 2 9 411 4 405 0 566 SNX6_HUMAN reviewed "Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]" SNX6 Homo sapiens (Human) 406 "endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle organization [GO:0016050]" GO:0005622; GO:0005634; GO:0005737; GO:0005829; GO:0006886; GO:0006897; GO:0007175; GO:0016023; GO:0016050; GO:0016241; GO:0019898; GO:0030512; GO:0030904; GO:0030905; GO:0031901; GO:0034452; GO:0035091; GO:0042147; GO:0042803; GO:0045892; GO:0046982; GO:0097422 0 0 0 PF00787;PF09325; Q9UNQ0 CHOYP_ABCG2.1.1 m.27887 sp ABCG2_HUMAN 48.089 628 317 5 21 645 32 653 0 621 ABCG2_HUMAN reviewed ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) ABCG2 ABCP BCRP BCRP1 MXR Homo sapiens (Human) 655 cellular iron ion homeostasis [GO:0006879]; cellular response to dexamethasone stimulus [GO:0071549]; drug export [GO:0046618]; embryonic process involved in female pregnancy [GO:0060136]; response to drug [GO:0042493]; response to folic acid [GO:0051593]; response to iron ion [GO:0010039]; transport [GO:0006810]; urate metabolic process [GO:0046415] GO:0005215; GO:0005524; GO:0005634; GO:0005886; GO:0006810; GO:0006879; GO:0008559; GO:0010039; GO:0015232; GO:0016021; GO:0016324; GO:0031966; GO:0042493; GO:0042626; GO:0042803; GO:0046415; GO:0046618; GO:0051593; GO:0060136; GO:0071549 0 0 0 PF01061;PF00005; Q9UNS1 CHOYP_LOC579123.1.1 m.65215 sp TIM_HUMAN 46.809 1128 559 9 2 1115 5 1105 0 992 TIM_HUMAN reviewed Protein timeless homolog (hTIM) TIMELESS TIM TIM1 TIMELESS1 Homo sapiens (Human) 1208 "branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; circadian rhythm [GO:0007623]; detection of abiotic stimulus [GO:0009582]; DNA replication [GO:0006260]; lung development [GO:0030324]; mitotic nuclear division [GO:0007067]; morphogenesis of an epithelium [GO:0002009]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of circadian rhythm [GO:0042752]; response to abiotic stimulus [GO:0009628]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0002009; GO:0005634; GO:0005654; GO:0005730; GO:0006260; GO:0006351; GO:0006974; GO:0007067; GO:0007623; GO:0009582; GO:0009628; GO:0015630; GO:0030324; GO:0042752; GO:0044770; GO:0045892; GO:0048754; GO:0051301 0 0 0 PF04821;PF05029; Q9UNX4 CHOYP_BRAFLDRAFT_114488.1.1 m.6260 sp WDR3_HUMAN 57.174 927 377 7 1 912 1 922 0 1060 WDR3_HUMAN reviewed WD repeat-containing protein 3 WDR3 Homo sapiens (Human) 943 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; rRNA processing [GO:0006364]" GO:0000462; GO:0005634; GO:0005654; GO:0005730; GO:0006364; GO:0030515; GO:0031965; GO:0032040; GO:0034388; GO:0044822 0 0 0 PF12894;PF04003;PF00400; Q9UP83 CHOYP_COG5.1.1 m.13833 sp COG5_HUMAN 59.556 811 287 7 10 810 56 835 0 992 COG5_HUMAN reviewed Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) COG5 GOLTC1 GTC90 Homo sapiens (Human) 839 ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031] GO:0000139; GO:0005654; GO:0005794; GO:0005829; GO:0006888; GO:0006891; GO:0015031; GO:0016020; GO:0017119; GO:0032588 0 0 0 PF10392; Q9UPR0 CHOYP_PLCL2.1.1 m.62311 sp PLCL2_HUMAN 54.473 1006 442 8 55 1051 101 1099 0 1148 PLCL2_HUMAN reviewed Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2) PLCL2 KIAA1092 PLCE2 Homo sapiens (Human) 1127 "B-1a B cell differentiation [GO:0002337]; B cell proliferation involved in immune response [GO:0002322]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; negative regulation of B cell receptor signaling pathway [GO:0050859]; positive regulation of receptor binding [GO:1900122]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of synaptic transmission, GABAergic [GO:0032228]" GO:0002322; GO:0002337; GO:0004435; GO:0004871; GO:0005737; GO:0006629; GO:0007214; GO:0032228; GO:0033135; GO:0035556; GO:0050811; GO:0050859; GO:1900122 0 0 0 PF00168;PF09279;PF16457;PF00388;PF00387; Q9UPU5 CHOYP_LOC592001.1.1 m.43470 sp UBP24_HUMAN 48.263 1036 479 8 4 989 5 1033 0 1003 UBP24_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) USP24 KIAA1057 Homo sapiens (Human) 2620 cell migration [GO:0016477]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005737; GO:0006511; GO:0016477; GO:0016579; GO:0036459 0 0 0 PF00443; Q9UPU5 CHOYP_UBP24.1.1 m.54945 sp UBP24_HUMAN 47.532 2310 1083 25 1 2218 305 2577 0 2107 UBP24_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24) USP24 KIAA1057 Homo sapiens (Human) 2620 cell migration [GO:0016477]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005737; GO:0006511; GO:0016477; GO:0016579; GO:0036459 0 0 0 PF00443; Q9V3H2 CHOYP_PSDE.1.1 m.38562 sp PSDE_DROME 89.389 311 30 1 1 311 1 308 0 579 PSDE_DROME reviewed 26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory complex subunit p37B) (26S proteasome regulatory subunit rpn11) (Yippee-interacting protein 5) Rpn11 yip5 CG18174 Drosophila melanogaster (Fruit fly) 308 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579] GO:0000502; GO:0004843; GO:0005838; GO:0005875; GO:0008237; GO:0008541; GO:0016579; GO:0043161; GO:0046872 0 0 0 PF01398;PF13012; Q9V3J1 CHOYP_LOC100648051.1.2 m.7363 sp VATH_DROME 60.22 455 176 2 128 582 17 466 0 594 VATH_DROME reviewed V-type proton ATPase subunit H (V-ATPase subunit H) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) VhaSFD CG17332 Drosophila melanogaster (Fruit fly) 468 ATP hydrolysis coupled proton transport [GO:0015991]; determination of adult lifespan [GO:0008340]; dsRNA transport [GO:0033227] GO:0000221; GO:0005886; GO:0008340; GO:0015991; GO:0033181; GO:0033227; GO:0046961 0 0 0 PF11698; Q9V3J1 CHOYP_LOC100648051.2.2 m.61174 sp VATH_DROME 59.657 466 178 3 145 610 11 466 0 590 VATH_DROME reviewed V-type proton ATPase subunit H (V-ATPase subunit H) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) VhaSFD CG17332 Drosophila melanogaster (Fruit fly) 468 ATP hydrolysis coupled proton transport [GO:0015991]; determination of adult lifespan [GO:0008340]; dsRNA transport [GO:0033227] GO:0000221; GO:0005886; GO:0008340; GO:0015991; GO:0033181; GO:0033227; GO:0046961 0 0 0 PF11698; Q9V3L1 CHOYP_NDST.1.1 m.8254 sp NDST_DROME 52.744 893 393 11 14 880 158 1047 0 953 NDST_DROME reviewed Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase) (Sulfateless) [Includes: Heparan sulfate N-deacetylase (EC 3.-.-.-); Heparan sulfate N-sulfotransferase (EC 2.8.2.-)] sfl CG8339 Drosophila melanogaster (Fruit fly) 1048 "cell surface receptor signaling pathway [GO:0007166]; epithelial cell migration, open tracheal system [GO:0007427]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycosaminoglycan biosynthetic process [GO:0006024]; heart development [GO:0007507]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing vein specification [GO:0007474]; intracellular distribution of mitochondria [GO:0048312]; mesoderm migration involved in gastrulation [GO:0007509]; primary branching, open tracheal system [GO:0007428]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of decapentaplegic signaling pathway [GO:0090097]; regulation of imaginal disc growth [GO:0045570]; segment polarity determination [GO:0007367]; spermatogenesis [GO:0007283]; sulfur compound metabolic process [GO:0006790]; synaptic vesicle endocytosis [GO:0048488]; Wnt signaling pathway [GO:0016055]" GO:0000137; GO:0000139; GO:0005622; GO:0005783; GO:0006024; GO:0006790; GO:0007166; GO:0007283; GO:0007367; GO:0007427; GO:0007428; GO:0007474; GO:0007507; GO:0007509; GO:0008146; GO:0008543; GO:0008587; GO:0015012; GO:0015014; GO:0015016; GO:0016021; GO:0016055; GO:0016787; GO:0030210; GO:0045202; GO:0045570; GO:0048312; GO:0048488; GO:0060828; GO:0090097 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis. 0 0 PF12062;PF00685; Q9V4A7 CHOYP_LOC100168635.1.1 m.55653 sp PLXB_DROME 34.67 2045 1080 61 32 1902 87 2049 0 1048 PLXB_DROME reviewed Plexin-B PlexB CG17245 Drosophila melanogaster (Fruit fly) 2051 axon guidance [GO:0007411]; motor neuron axon guidance [GO:0008045]; negative regulation of Rac protein signal transduction [GO:0035021]; olfactory bulb axon guidance [GO:0071678]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sensory neuron axon guidance [GO:0097374] GO:0002116; GO:0005886; GO:0005887; GO:0007411; GO:0008045; GO:0017154; GO:0030334; GO:0035021; GO:0035025; GO:0048841; GO:0071678; GO:0097374; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q9V6L0 CHOYP_KDM4C.1.1 m.24912 sp KDM4B_DROME 73.294 337 87 1 10 343 6 342 0 569 KDM4B_DROME reviewed Probable lysine-specific demethylase 4B (EC 1.14.11.-) (Probable JmjC domain-containing histone demethylation protein 3B) Kdm4B CG33182 Drosophila melanogaster (Fruit fly) 590 "histone demethylation [GO:0016577]; histone H3-K36 demethylation [GO:0070544]; histone H3-K9 demethylation [GO:0033169]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0016577; GO:0032454; GO:0033169; GO:0045892; GO:0046872; GO:0051864; GO:0070544 0 0 0 PF02373;PF02375; Q9V9J3 CHOYP_SRC2.1.1 m.6537 sp SRC42_DROME 73.814 527 124 4 1 524 1 516 0 796 SRC42_DROME reviewed Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Tyrosine-protein kinase Src41) (Dsrc41) Src42A Src41 TK5 CG44128 Drosophila melanogaster (Fruit fly) 517 "actin filament bundle assembly [GO:0051017]; adherens junction organization [GO:0034332]; apoptotic cell clearance [GO:0043277]; axon guidance [GO:0007411]; cell migration [GO:0016477]; compound eye development [GO:0048749]; defense response to bacterium [GO:0042742]; dorsal closure [GO:0007391]; dorsal closure, spreading of leading edge cells [GO:0007395]; epithelial cell-cell adhesion [GO:0090136]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc fusion, thorax closure [GO:0046529]; innate immune response [GO:0045087]; intestinal stem cell homeostasis [GO:0036335]; JNK cascade [GO:0007254]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; open tracheal system development [GO:0007424]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; salivary gland morphogenesis [GO:0007435]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; tricarboxylic acid cycle [GO:0006099]" GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005737; GO:0005886; GO:0005912; GO:0006099; GO:0006468; GO:0007169; GO:0007254; GO:0007391; GO:0007395; GO:0007411; GO:0007424; GO:0007435; GO:0007476; GO:0016477; GO:0018108; GO:0019233; GO:0031234; GO:0034332; GO:0036335; GO:0038083; GO:0042059; GO:0042127; GO:0042742; GO:0043277; GO:0045087; GO:0045886; GO:0046529; GO:0048749; GO:0051017; GO:0090136 0 0 0 PF07714;PF00017;PF00018; Q9VA73 CHOYP_LOC100901947.1.1 m.7834 sp CMC_DROME 57.522 678 267 8 19 687 15 680 0 805 CMC_DROME reviewed Calcium-binding mitochondrial carrier protein Aralar1 aralar1 CG2139 Drosophila melanogaster (Fruit fly) 695 translation [GO:0006412]; transmembrane transport [GO:0055085]; wound healing [GO:0042060] GO:0003735; GO:0005509; GO:0005739; GO:0005743; GO:0005811; GO:0006412; GO:0016021; GO:0042060; GO:0055085 0 0 0 PF13833;PF00153; Q9VB11 CHOYP_PHUM_PHUM244880.1.2 m.691 sp UNC80_DROME 37.456 2296 1215 57 3 2193 795 2974 0 1462 UNC80_DROME reviewed Protein unc-80 homolog unc80 CG18437 Drosophila melanogaster (Fruit fly) 3303 cation homeostasis [GO:0055080]; locomotor rhythm [GO:0045475] GO:0005261; GO:0034703; GO:0045475; GO:0055080 0 0 0 PF15778; Q9VB11 CHOYP_PHUM_PHUM244880.2.2 m.41653 sp UNC80_DROME 36.856 2195 1139 53 701 2789 713 2766 0 1362 UNC80_DROME reviewed Protein unc-80 homolog unc80 CG18437 Drosophila melanogaster (Fruit fly) 3303 cation homeostasis [GO:0055080]; locomotor rhythm [GO:0045475] GO:0005261; GO:0034703; GO:0045475; GO:0055080 0 0 0 PF15778; Q9VEN1 CHOYP_CHER.1.1 m.63350 sp FLNA_DROME 43.401 841 463 8 23 854 1372 2208 0 696 FLNA_DROME reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Filamin-1) (Filamin1) cher cheerio sko CG3937 Drosophila melanogaster (Fruit fly) 2210 "behavioral response to ethanol [GO:0048149]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; determination of adult lifespan [GO:0008340]; female germline ring canal formation [GO:0007301]; female germline ring canal formation, actin assembly [GO:0008302]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germline ring canal formation [GO:0030725]; learning or memory [GO:0007611]; mitotic nuclear division [GO:0007067]; motor neuron axon guidance [GO:0008045]; negative regulation of lamellocyte differentiation [GO:0035204]; olfactory learning [GO:0008355]; positive regulation of cytoskeleton organization [GO:0051495]; protein localization [GO:0008104]; sleep [GO:0030431]" GO:0003779; GO:0005829; GO:0005886; GO:0007067; GO:0007301; GO:0007303; GO:0007611; GO:0008045; GO:0008104; GO:0008302; GO:0008340; GO:0008355; GO:0015629; GO:0030431; GO:0030708; GO:0030725; GO:0035182; GO:0035183; GO:0035204; GO:0035324; GO:0045179; GO:0048149; GO:0051495 0 0 0 PF00307;PF00630; Q9VEN1 CHOYP_FLNA.2.6 m.11845 sp FLNA_DROME 51.022 2250 1031 24 21 2242 4 2210 0 2251 FLNA_DROME reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Filamin-1) (Filamin1) cher cheerio sko CG3937 Drosophila melanogaster (Fruit fly) 2210 "behavioral response to ethanol [GO:0048149]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; determination of adult lifespan [GO:0008340]; female germline ring canal formation [GO:0007301]; female germline ring canal formation, actin assembly [GO:0008302]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germline ring canal formation [GO:0030725]; learning or memory [GO:0007611]; mitotic nuclear division [GO:0007067]; motor neuron axon guidance [GO:0008045]; negative regulation of lamellocyte differentiation [GO:0035204]; olfactory learning [GO:0008355]; positive regulation of cytoskeleton organization [GO:0051495]; protein localization [GO:0008104]; sleep [GO:0030431]" GO:0003779; GO:0005829; GO:0005886; GO:0007067; GO:0007301; GO:0007303; GO:0007611; GO:0008045; GO:0008104; GO:0008302; GO:0008340; GO:0008355; GO:0015629; GO:0030431; GO:0030708; GO:0030725; GO:0035182; GO:0035183; GO:0035204; GO:0035324; GO:0045179; GO:0048149; GO:0051495 0 0 0 PF00307;PF00630; Q9VEN1 CHOYP_FLNB.1.1 m.55734 sp FLNA_DROME 60.314 509 187 4 21 528 4 498 0 639 FLNA_DROME reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Filamin-1) (Filamin1) cher cheerio sko CG3937 Drosophila melanogaster (Fruit fly) 2210 "behavioral response to ethanol [GO:0048149]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; determination of adult lifespan [GO:0008340]; female germline ring canal formation [GO:0007301]; female germline ring canal formation, actin assembly [GO:0008302]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germline ring canal formation [GO:0030725]; learning or memory [GO:0007611]; mitotic nuclear division [GO:0007067]; motor neuron axon guidance [GO:0008045]; negative regulation of lamellocyte differentiation [GO:0035204]; olfactory learning [GO:0008355]; positive regulation of cytoskeleton organization [GO:0051495]; protein localization [GO:0008104]; sleep [GO:0030431]" GO:0003779; GO:0005829; GO:0005886; GO:0007067; GO:0007301; GO:0007303; GO:0007611; GO:0008045; GO:0008104; GO:0008302; GO:0008340; GO:0008355; GO:0015629; GO:0030431; GO:0030708; GO:0030725; GO:0035182; GO:0035183; GO:0035204; GO:0035324; GO:0045179; GO:0048149; GO:0051495 0 0 0 PF00307;PF00630; Q9VF87 CHOYP_LOC100533349.1.5 m.21764 sp CYFIP_DROME 69.402 585 176 2 8 592 3 584 0 858 CYFIP_DROME reviewed Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) (DSra-1) Sra-1 Cyfip CG4931 Drosophila melanogaster (Fruit fly) 1291 axon guidance [GO:0007411]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chaeta development [GO:0022416]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807] GO:0000902; GO:0001745; GO:0005737; GO:0006909; GO:0007411; GO:0008360; GO:0022416; GO:0030031; GO:0030866; GO:0031209; GO:0033627; GO:0045177; GO:0045202; GO:0050807 0 0 0 PF07159;PF05994; Q9VF87 CHOYP_LOC100533349.2.5 m.39292 sp CYFIP_DROME 60.764 1282 463 9 6 1259 2 1271 0 1644 CYFIP_DROME reviewed Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) (DSra-1) Sra-1 Cyfip CG4931 Drosophila melanogaster (Fruit fly) 1291 axon guidance [GO:0007411]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chaeta development [GO:0022416]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807] GO:0000902; GO:0001745; GO:0005737; GO:0006909; GO:0007411; GO:0008360; GO:0022416; GO:0030031; GO:0030866; GO:0031209; GO:0033627; GO:0045177; GO:0045202; GO:0050807 0 0 0 PF07159;PF05994; Q9VF87 CHOYP_LOC100533349.3.5 m.52212 sp CYFIP_DROME 67.039 1253 374 8 4 1229 35 1275 0 1793 CYFIP_DROME reviewed Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) (DSra-1) Sra-1 Cyfip CG4931 Drosophila melanogaster (Fruit fly) 1291 axon guidance [GO:0007411]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chaeta development [GO:0022416]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807] GO:0000902; GO:0001745; GO:0005737; GO:0006909; GO:0007411; GO:0008360; GO:0022416; GO:0030031; GO:0030866; GO:0031209; GO:0033627; GO:0045177; GO:0045202; GO:0050807 0 0 0 PF07159;PF05994; Q9VF87 CHOYP_LOC100533349.4.5 m.59790 sp CYFIP_DROME 58.268 1282 496 8 6 1260 2 1271 0 1561 CYFIP_DROME reviewed Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) (DSra-1) Sra-1 Cyfip CG4931 Drosophila melanogaster (Fruit fly) 1291 axon guidance [GO:0007411]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chaeta development [GO:0022416]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807] GO:0000902; GO:0001745; GO:0005737; GO:0006909; GO:0007411; GO:0008360; GO:0022416; GO:0030031; GO:0030866; GO:0031209; GO:0033627; GO:0045177; GO:0045202; GO:0050807 0 0 0 PF07159;PF05994; Q9VF87 CHOYP_LOC100533349.5.5 m.62029 sp CYFIP_DROME 63.092 1287 436 8 6 1265 1 1275 0 1708 CYFIP_DROME reviewed Cytoplasmic FMR1-interacting protein (Specifically Rac1-associated protein 1) (DSra-1) Sra-1 Cyfip CG4931 Drosophila melanogaster (Fruit fly) 1291 axon guidance [GO:0007411]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; chaeta development [GO:0022416]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360]; regulation of synapse organization [GO:0050807] GO:0000902; GO:0001745; GO:0005737; GO:0006909; GO:0007411; GO:0008360; GO:0022416; GO:0030031; GO:0030866; GO:0031209; GO:0033627; GO:0045177; GO:0045202; GO:0050807 0 0 0 PF07159;PF05994; Q9VFC8 CHOYP_LOC100368259.1.1 m.39485 sp GYS_DROME 63.401 694 240 3 1 685 19 707 0 920 GYS_DROME reviewed Glycogen [starch] synthase (EC 2.4.1.11) (Glycogen synthase) GlyS CG6904 Drosophila melanogaster (Fruit fly) 709 cellular response to starvation [GO:0009267]; cellular response to sucrose stimulus [GO:0071329]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; glycophagy [GO:0061723]; positive regulation of glycogen catabolic process [GO:0045819]; response to sucrose [GO:0009744] GO:0004373; GO:0005776; GO:0005977; GO:0005978; GO:0009267; GO:0009744; GO:0031410; GO:0045819; GO:0061723; GO:0071329 PATHWAY: Glycan biosynthesis; glycogen biosynthesis. 0 0 PF05693; Q9VFP2 CHOYP_RDX.1.1 m.19245 sp RDX_DROME 84.071 339 54 0 4 342 472 810 0 583 RDX_DROME reviewed Protein roadkill (Hh-induced MATH and BTB domain-containing protein) rdx HIB CG12537 Drosophila melanogaster (Fruit fly) 829 establishment of ommatidial planar polarity [GO:0042067]; eye development [GO:0001654]; eye morphogenesis [GO:0048592]; lateral inhibition [GO:0046331]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of proteolysis [GO:0030162]; segment polarity determination [GO:0007367] GO:0001654; GO:0005634; GO:0007367; GO:0016567; GO:0030162; GO:0031648; GO:0042067; GO:0042308; GO:0042803; GO:0043065; GO:0045879; GO:0046330; GO:0046331; GO:0048592 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00651;PF00917; Q9VH19 CHOYP_LMLN.1.1 m.7283 sp LMLN_DROME 43.114 668 354 13 3 649 16 678 0 543 LMLN_DROME reviewed Leishmanolysin-like peptidase (EC 3.4.24.-) (Invadolysin) Invadolysin l(3)IX-14 CG3953 Drosophila melanogaster (Fruit fly) 683 brain development [GO:0007420]; cell adhesion [GO:0007155]; cell division [GO:0051301]; centrosome duplication [GO:0051298]; chromatin remodeling [GO:0006338]; electron transport chain [GO:0022900]; germ cell migration [GO:0008354]; gonad development [GO:0008406]; imaginal disc development [GO:0007444]; lipid storage [GO:0019915]; mitotic centrosome separation [GO:0007100]; mitotic chromosome condensation [GO:0007076]; mitotic spindle organization [GO:0007052]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; regulation of choline O-acetyltransferase activity [GO:1902769] GO:0004222; GO:0005737; GO:0006338; GO:0007052; GO:0007076; GO:0007100; GO:0007155; GO:0007420; GO:0007444; GO:0008233; GO:0008354; GO:0008406; GO:0016020; GO:0019915; GO:0022900; GO:0031252; GO:0045842; GO:0046872; GO:0051298; GO:0051301; GO:1902769 0 0 0 PF01457; Q9VJ79 CHOYP_PDE11.1.3 m.8788 sp PDE11_DROME 59.56 727 273 5 126 844 387 1100 0 896 PDE11_DROME reviewed "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11)" Pde11 CG34341 Drosophila melanogaster (Fruit fly) 1451 cAMP metabolic process [GO:0046058]; cGMP metabolic process [GO:0046068]; lateral inhibition [GO:0046331]; signal transduction [GO:0007165] GO:0004115; GO:0005829; GO:0007165; GO:0046058; GO:0046068; GO:0046331; GO:0046872; GO:0047555 0 0 0 PF01590;PF00233; Q9VJ87 CHOYP_CWC22.1.1 m.29270 sp CWC22_DROME 59.663 652 237 5 344 989 304 935 0 830 CWC22_DROME reviewed Pre-mRNA-splicing factor CWC22 homolog (Nucampholin) ncm CG12750 Drosophila melanogaster (Fruit fly) 1330 "mRNA splicing, via spliceosome [GO:0000398]; phagocytosis [GO:0006909]" GO:0000398; GO:0003723; GO:0005681; GO:0006909; GO:0016607; GO:0071006; GO:0071013 0 0 0 PF02847; Q9VJJ7 CHOYP_TRPG.1.1 m.27084 sp TRPG_DROME 57.506 786 305 7 78 844 17 792 0 923 TRPG_DROME reviewed Transient receptor potential-gamma protein (TRPgamma) (Transient receptor potential cation channel gamma) Trpgamma CG5996 Drosophila melanogaster (Fruit fly) 1128 adult walking behavior [GO:0007628]; calcium ion transport [GO:0006816]; cation transport [GO:0006812]; detection of light stimulus involved in visual perception [GO:0050908]; manganese ion transport [GO:0006828]; neuromuscular process controlling posture [GO:0050884]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to light stimulus [GO:0009416] GO:0005261; GO:0005262; GO:0005887; GO:0006812; GO:0006816; GO:0006828; GO:0007628; GO:0009416; GO:0015279; GO:0016028; GO:0022833; GO:0034703; GO:0043025; GO:0050884; GO:0050908; GO:0051480; GO:1990635 0 0 0 PF00023;PF00520;PF08344; Q9VLC0 CHOYP_VPS54.1.1 m.7451 sp VPS54_DROME 37.231 975 523 18 6 958 31 938 0 649 VPS54_DROME reviewed Vacuolar protein sorting-associated protein 54 (Protein scattered) scat CG3766 Drosophila melanogaster (Fruit fly) 940 "endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; spermatid development [GO:0007286]; sperm individualization [GO:0007291]" GO:0000938; GO:0005739; GO:0005794; GO:0005829; GO:0006896; GO:0007286; GO:0007291; GO:0015031; GO:0019905; GO:0032456; GO:0042147 0 0 0 PF07928;PF10475; Q9VLN1 CHOYP_LOC654994.1.1 m.39461 sp WDR82_DROME 76.375 309 73 0 1 309 3 311 0 521 WDR82_DROME reviewed WD repeat-containing protein 82 Wdr82 CG17293 Drosophila melanogaster (Fruit fly) 317 histone H3-K4 methylation [GO:0051568]; histone H3-K4 trimethylation [GO:0080182]; sensory perception of pain [GO:0019233] GO:0019233; GO:0035097; GO:0048188; GO:0051568; GO:0080182 0 0 0 PF00400; Q9VN03 CHOYP_SUV3.1.1 m.14574 sp SUV3_DROME 48.058 618 317 2 91 708 52 665 0 610 SUV3_DROME reviewed "ATP-dependent RNA helicase SUV3 homolog, mitochondrial (EC 3.6.4.13)" CG9791 Drosophila melanogaster (Fruit fly) 763 DNA duplex unwinding [GO:0032508]; mitochondrial mRNA polyadenylation [GO:0097222]; mitochondrial RNA processing [GO:0000963]; mitochondrial tRNA processing [GO:0090646]; oxidative phosphorylation [GO:0006119]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]; respiratory electron transport chain [GO:0022904] GO:0000963; GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0005739; GO:0005759; GO:0006119; GO:0022904; GO:0032508; GO:0044528; GO:0070131; GO:0090646; GO:0097222 0 0 0 PF00271;PF12513; Q9VP61 CHOYP_ACSA.1.1 m.61294 sp ACSA_DROME 64.012 678 227 5 32 707 7 669 0 931 ACSA_DROME reviewed Acetyl-coenzyme A synthetase (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-activating enzyme) AcCoAS CG9390 Drosophila melanogaster (Fruit fly) 670 acetyl-CoA biosynthetic process from acetate [GO:0019427]; behavioral response to ethanol [GO:0048149] GO:0003987; GO:0005524; GO:0005737; GO:0016208; GO:0019427; GO:0048149 0 0 cd05966; PF16177;PF00501;PF13193; Q9VQH2 CHOYP_DUOX1.3.4 m.34160 sp DUOX_DROME 39.843 1526 839 22 29 1534 70 1536 0 1148 DUOX_DROME reviewed Dual oxidase (EC 1.11.1.-) (EC 1.6.3.1) Duox CG3131 Drosophila melanogaster (Fruit fly) 1537 adult chitin-based cuticle development [GO:0008365]; adult chitin-containing cuticle pigmentation [GO:0048085]; cuticle development [GO:0042335]; cytokine-mediated signaling pathway [GO:0019221]; defense response to bacterium [GO:0042742]; hydrogen peroxide catabolic process [GO:0042744]; mucosal immune response [GO:0002385]; negative regulation of apoptotic process [GO:0043066]; reactive oxygen species metabolic process [GO:0072593]; response to cAMP [GO:0051591]; response to oxidative stress [GO:0006979]; wing disc development [GO:0035220] GO:0002385; GO:0004601; GO:0005509; GO:0006979; GO:0008365; GO:0012505; GO:0016021; GO:0016174; GO:0019221; GO:0020037; GO:0035220; GO:0042335; GO:0042742; GO:0042744; GO:0043066; GO:0048085; GO:0051591; GO:0072593 0 0 0 PF03098;PF00036;PF13499;PF08022;PF01794;PF08030; Q9VQX4 CHOYP_PNCB.1.1 m.57201 sp PNCB_DROME 67.103 535 176 0 36 570 21 555 0 748 PNCB_DROME reviewed Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) CG3714 Drosophila melanogaster (Fruit fly) 555 NAD biosynthetic process [GO:0009435]; nicotinate nucleotide salvage [GO:0019358]; response to oxidative stress [GO:0006979] GO:0004514; GO:0004516; GO:0005829; GO:0006979; GO:0009435; GO:0016874; GO:0019358 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. 0 0 PF04095; Q9VR07 CHOYP_BRAFLDRAFT_213699.1.1 m.56208 sp INE_DROME 49.002 551 266 4 4 552 337 874 0 585 INE_DROME reviewed Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) 943 glial cell growth [GO:0042065]; multicellular organismal water homeostasis [GO:0050891]; neurotransmitter transport [GO:0006836]; perineurial glial growth [GO:0042066]; regulation of response to osmotic stress [GO:0047484]; response to water deprivation [GO:0009414]; transmission of nerve impulse [GO:0019226]; transport [GO:0006810] GO:0005034; GO:0005215; GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0006836; GO:0009414; GO:0009881; GO:0016021; GO:0016323; GO:0019226; GO:0042065; GO:0042066; GO:0047484; GO:0050891 0 0 0 PF00209; Q9VR59 CHOYP_VIP2.1.1 m.54883 sp VIP1_DROME 64.726 876 298 3 46 913 65 937 0 1191 VIP1_DROME reviewed Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.21) (EC 2.7.4.24) (InsP6 and PP-IP5 kinase) l(1)G0196 CG14616 Drosophila melanogaster (Fruit fly) 1696 inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958] GO:0000827; GO:0000828; GO:0000829; GO:0000832; GO:0005524; GO:0005829; GO:0006020; GO:0032958; GO:0033857; GO:0052723; GO:0052724 0 0 cd07061; PF00328; Q9VRP9 CHOYP_LOC660381.1.1 m.6379 sp BRE1_DROME 50.24 832 306 12 327 1054 216 1043 0 727 BRE1_DROME reviewed E3 ubiquitin-protein ligase Bre1 (EC 6.3.2.-) (dBre1) Bre1 CG10542 Drosophila melanogaster (Fruit fly) 1044 histone modification [GO:0016570]; histone ubiquitination [GO:0016574]; Notch signaling pathway [GO:0007219]; phagocytosis [GO:0006909]; protein monoubiquitination [GO:0006513]; sleep [GO:0030431] GO:0004842; GO:0005634; GO:0006513; GO:0006909; GO:0007219; GO:0008270; GO:0016570; GO:0016574; GO:0016874; GO:0030431 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00097; Q9VT65 CHOYP_LOC100747565.1.2 m.1707 sp CANB_DROME 50.41 732 307 5 100 827 246 925 0 746 CANB_DROME reviewed Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) 925 border follicle cell migration [GO:0007298]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; sensory perception of pain [GO:0019233] GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0007298; GO:0016020; GO:0016540; GO:0019233 0 0 0 PF01067;PF00648; Q9VT65 CHOYP_LOC100882339.2.2 m.53385 sp CANB_DROME 53.813 695 310 5 22 705 231 925 0 780 CANB_DROME reviewed Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) 925 border follicle cell migration [GO:0007298]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; sensory perception of pain [GO:0019233] GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0007298; GO:0016020; GO:0016540; GO:0019233 0 0 0 PF01067;PF00648; Q9VT65 CHOYP_SMP_089460.1.1.1 m.34779 sp CANB_DROME 54.118 680 301 5 129 797 246 925 0 768 CANB_DROME reviewed Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) 925 border follicle cell migration [GO:0007298]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; sensory perception of pain [GO:0019233] GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0007298; GO:0016020; GO:0016540; GO:0019233 0 0 0 PF01067;PF00648; Q9VT65 CHOYP_SMP_089460.2.1.1 m.431 sp CANB_DROME 52.632 703 303 6 100 795 246 925 0 760 CANB_DROME reviewed Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) 925 border follicle cell migration [GO:0007298]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; sensory perception of pain [GO:0019233] GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0007298; GO:0016020; GO:0016540; GO:0019233 0 0 0 PF01067;PF00648; Q9VTK2 CHOYP_LOC100871274.1.1 m.42015 sp POMT1_DROME 47.476 733 372 5 58 784 155 880 0 731 POMT1_DROME reviewed Protein O-mannosyltransferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) (dPOMT1) (Protein rotated abdomen) rt POMT1 CG6097 Drosophila melanogaster (Fruit fly) 886 "cell wall mannoprotein biosynthetic process [GO:0000032]; chain elongation of O-linked mannose residue [GO:0044845]; lipid glycosylation [GO:0030259]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; protein O-linked mannosylation [GO:0035269]; regulation of endoplasmic reticulum unfolded protein response [GO:1900101]; regulation of synaptic activity [GO:0060025]; sarcomere organization [GO:0045214]; somatic muscle development [GO:0007525]; specification of segmental identity, abdomen [GO:0007385]" GO:0000032; GO:0004169; GO:0005783; GO:0007385; GO:0007517; GO:0007525; GO:0016021; GO:0016203; GO:0030259; GO:0031502; GO:0035269; GO:0044845; GO:0045214; GO:0060025; GO:1900101 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02815;PF02366;PF16192; Q9VU68 CHOYP_WDR1.1.1 m.29076 sp WDR1_DROME 49.094 607 294 9 3 602 8 606 0 607 WDR1_DROME reviewed Actin-interacting protein 1 (AIP1) (Protein flare) flr CG10724 Drosophila melanogaster (Fruit fly) 608 actin filament depolymerization [GO:0030042]; border follicle cell migration [GO:0007298]; establishment of planar polarity [GO:0001736]; imaginal disc-derived wing hair organization [GO:0035317]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; phagocytosis [GO:0006909]; regulation of actin filament depolymerization [GO:0030834]; regulation of actin filament polymerization [GO:0030833]; sarcomere organization [GO:0045214] GO:0001736; GO:0003779; GO:0005737; GO:0005856; GO:0006909; GO:0007298; GO:0030042; GO:0030833; GO:0030834; GO:0034316; GO:0035317; GO:0045214 0 0 0 PF00400; Q9VW26 CHOYP_OAT.1.1 m.3069 sp OAT_DROME 73.832 428 108 2 1 424 1 428 0 669 OAT_DROME reviewed "Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase)" Oat CG8782 Drosophila melanogaster (Fruit fly) 431 arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; L-proline biosynthetic process [GO:0055129]; neurogenesis [GO:0022008] GO:0004587; GO:0005739; GO:0005759; GO:0010121; GO:0019544; GO:0022008; GO:0030170; GO:0042802; GO:0055129 PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1. 0 cd00610; PF00202; Q9VX32 CHOYP_LOC661306.1.3 m.11419 sp RG190_DROME 34.808 1017 602 20 8 997 2 984 0 596 RG190_DROME reviewed Rho GTPase-activating protein 190 (Rho GTPase-activating protein of 190 kDa) RhoGAPp190 CG32555 Drosophila melanogaster (Fruit fly) 1561 defasciculation of motor neuron axon [GO:0007415]; mushroom body development [GO:0016319]; negative regulation of cell size [GO:0045792]; regulation of axonogenesis [GO:0050770]; Rho protein signal transduction [GO:0007266] GO:0005096; GO:0005525; GO:0005622; GO:0007266; GO:0007415; GO:0016319; GO:0030215; GO:0045792; GO:0050770 0 0 0 PF00071;PF00620;PF16512; Q9VX32 CHOYP_LOC661306.2.3 m.23806 sp RG190_DROME 34.638 1022 602 21 8 1002 2 984 0 590 RG190_DROME reviewed Rho GTPase-activating protein 190 (Rho GTPase-activating protein of 190 kDa) RhoGAPp190 CG32555 Drosophila melanogaster (Fruit fly) 1561 defasciculation of motor neuron axon [GO:0007415]; mushroom body development [GO:0016319]; negative regulation of cell size [GO:0045792]; regulation of axonogenesis [GO:0050770]; Rho protein signal transduction [GO:0007266] GO:0005096; GO:0005525; GO:0005622; GO:0007266; GO:0007415; GO:0016319; GO:0030215; GO:0045792; GO:0050770 0 0 0 PF00071;PF00620;PF16512; Q9VX32 CHOYP_LOC661306.3.3 m.26158 sp RG190_DROME 34.638 1022 602 21 8 1002 2 984 0 589 RG190_DROME reviewed Rho GTPase-activating protein 190 (Rho GTPase-activating protein of 190 kDa) RhoGAPp190 CG32555 Drosophila melanogaster (Fruit fly) 1561 defasciculation of motor neuron axon [GO:0007415]; mushroom body development [GO:0016319]; negative regulation of cell size [GO:0045792]; regulation of axonogenesis [GO:0050770]; Rho protein signal transduction [GO:0007266] GO:0005096; GO:0005525; GO:0005622; GO:0007266; GO:0007415; GO:0016319; GO:0030215; GO:0045792; GO:0050770 0 0 0 PF00071;PF00620;PF16512; Q9VYY9 CHOYP_LOC100378224.1.1 m.4326 sp EVI5_DROME 45.838 829 373 14 21 811 10 800 0 676 EVI5_DROME reviewed Ecotropic viral integration site 5 ortholog Evi5 CG11727 Drosophila melanogaster (Fruit fly) 807 activation of GTPase activity [GO:0090630]; border follicle cell migration [GO:0007298]; intracellular protein transport [GO:0006886]; regulation of cell migration [GO:0030334]; regulation of GTPase activity [GO:0043087]; regulation of protein localization [GO:0032880]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005737; GO:0005768; GO:0005794; GO:0006886; GO:0007298; GO:0017137; GO:0030334; GO:0031338; GO:0031982; GO:0032880; GO:0043087; GO:0090630 0 0 0 PF00566; Q9VZI3 CHOYP_LOC100366451.1.1 m.10501 sp UN112_DROME 48.199 722 320 13 12 698 6 708 0 661 UN112_DROME reviewed Unc-112-related protein (Fermitin-1) Fit1 CG14991 Drosophila melanogaster (Fruit fly) 708 cardiac muscle tissue development [GO:0048738]; cell-matrix adhesion [GO:0007160]; defense response to Gram-negative bacterium [GO:0050829] GO:0005737; GO:0007160; GO:0048738; GO:0050829; GO:0050839 0 0 0 PF00373;PF00169; Q9VZI3 CHOYP_LOC100865274.1.1 m.1854 sp UN112_DROME 48.061 722 321 13 12 698 6 708 0 658 UN112_DROME reviewed Unc-112-related protein (Fermitin-1) Fit1 CG14991 Drosophila melanogaster (Fruit fly) 708 cardiac muscle tissue development [GO:0048738]; cell-matrix adhesion [GO:0007160]; defense response to Gram-negative bacterium [GO:0050829] GO:0005737; GO:0007160; GO:0048738; GO:0050829; GO:0050839 0 0 0 PF00373;PF00169; Q9W391 CHOYP_LOC100368228.3.3 m.54183 sp KPBA_DROME 52.239 1273 505 18 39 1234 1 1247 0 1252 KPBA_DROME reviewed Probable phosphorylase b kinase regulatory subunit alpha (Phosphorylase kinase subunit alpha) CG7766 Drosophila melanogaster (Fruit fly) 1247 glycogen metabolic process [GO:0005977]; protein phosphorylation [GO:0006468] GO:0003824; GO:0005886; GO:0005964; GO:0005977; GO:0006468 PATHWAY: Glycan biosynthesis; glycogen metabolism. 0 0 PF00723; Q9W391 CHOYP_LOC100643035.1.1 m.29398 sp KPBA_DROME 51.972 1293 506 18 1 1224 1 1247 0 1255 KPBA_DROME reviewed Probable phosphorylase b kinase regulatory subunit alpha (Phosphorylase kinase subunit alpha) CG7766 Drosophila melanogaster (Fruit fly) 1247 glycogen metabolic process [GO:0005977]; protein phosphorylation [GO:0006468] GO:0003824; GO:0005886; GO:0005964; GO:0005977; GO:0006468 PATHWAY: Glycan biosynthesis; glycogen metabolism. 0 0 PF00723; Q9W4E2 CHOYP_LOC100646535.1.1 m.61774 sp NBEA_DROME 61.704 1115 398 7 1646 2737 2358 3466 0 1513 NBEA_DROME reviewed Neurobeachin (A-kinase anchor protein 550) (AKAP 550) (Protein rugose) (dAKAP550) rg Akap550 CG44835 Drosophila melanogaster (Fruit fly) 3466 compound eye cone cell differentiation [GO:0042675]; eye photoreceptor cell development [GO:0042462]; mushroom body development [GO:0016319]; neuromuscular junction development [GO:0007528]; olfactory learning [GO:0008355]; short-term memory [GO:0007614] GO:0005737; GO:0007528; GO:0007614; GO:0008355; GO:0016021; GO:0016319; GO:0042462; GO:0042675; GO:0043025; GO:0043204; GO:0051018 0 0 cd06071; PF02138;PF06469;PF15787;PF14844;PF00400; Q9W4E2 CHOYP_LOC724172.1.1 m.24081 sp NBEA_DROME 60.987 1115 379 7 1313 2377 2358 3466 0 1493 NBEA_DROME reviewed Neurobeachin (A-kinase anchor protein 550) (AKAP 550) (Protein rugose) (dAKAP550) rg Akap550 CG44835 Drosophila melanogaster (Fruit fly) 3466 compound eye cone cell differentiation [GO:0042675]; eye photoreceptor cell development [GO:0042462]; mushroom body development [GO:0016319]; neuromuscular junction development [GO:0007528]; olfactory learning [GO:0008355]; short-term memory [GO:0007614] GO:0005737; GO:0007528; GO:0007614; GO:0008355; GO:0016021; GO:0016319; GO:0042462; GO:0042675; GO:0043025; GO:0043204; GO:0051018 0 0 cd06071; PF02138;PF06469;PF15787;PF14844;PF00400; Q9W4P5 CHOYP_VA0D1.1.2 m.31117 sp VA0D1_DROME 71.354 384 69 1 10 393 8 350 0 566 VA0D1_DROME reviewed V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (V-ATPase 39 kDa subunit) (Vacuolar H+ ATPase subunit AC39-1) (Vacuolar proton pump subunit d 1) VhaAC39-1 VhaAC39 CG2934 Drosophila melanogaster (Fruit fly) 350 "ATP hydrolysis coupled proton transport [GO:0015991]; regulation of Notch signaling pathway [GO:0008593]; terminal branching, open tracheal system [GO:0007430]; vacuolar acidification [GO:0007035]" GO:0000220; GO:0005886; GO:0007035; GO:0007430; GO:0008593; GO:0015991; GO:0033181; GO:0046961 0 0 0 PF01992; Q9W4P5 CHOYP_VA0D1.2.2 m.53236 sp VA0D1_DROME 79.883 343 69 0 10 352 8 350 0 586 VA0D1_DROME reviewed V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (V-ATPase 39 kDa subunit) (Vacuolar H+ ATPase subunit AC39-1) (Vacuolar proton pump subunit d 1) VhaAC39-1 VhaAC39 CG2934 Drosophila melanogaster (Fruit fly) 350 "ATP hydrolysis coupled proton transport [GO:0015991]; regulation of Notch signaling pathway [GO:0008593]; terminal branching, open tracheal system [GO:0007430]; vacuolar acidification [GO:0007035]" GO:0000220; GO:0005886; GO:0007035; GO:0007430; GO:0008593; GO:0015991; GO:0033181; GO:0046961 0 0 0 PF01992; Q9WTX6 CHOYP_CUL1.1.1 m.13087 sp CUL1_MOUSE 80.051 782 145 4 1 777 1 776 0 1306 CUL1_MOUSE reviewed Cullin-1 (CUL-1) Cul1 Mus musculus (Mouse) 776 apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; organ morphogenesis [GO:0009887]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032] GO:0004842; GO:0006511; GO:0006513; GO:0006915; GO:0008283; GO:0009887; GO:0016032; GO:0016567; GO:0019005; GO:0031146; GO:0031461; GO:0031625; GO:0042787; GO:1990452 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00888;PF10557; Q9WU22 CHOYP_PTN4.1.2 m.1771 sp PTN4_MOUSE 52.245 980 346 20 45 962 1 920 0 951 PTN4_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Testis-enriched protein tyrosine phosphatase) Ptpn4 Mus musculus (Mouse) 926 0 GO:0004726; GO:0005737; GO:0005856; GO:0009898 0 0 0 PF08736;PF09380;PF00373;PF09379;PF00595;PF00102; Q9WU22 CHOYP_PTN4.2.2 m.66689 sp PTN4_MOUSE 53.163 980 360 19 1 941 1 920 0 986 PTN4_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Testis-enriched protein tyrosine phosphatase) Ptpn4 Mus musculus (Mouse) 926 0 GO:0004726; GO:0005737; GO:0005856; GO:0009898 0 0 0 PF08736;PF09380;PF00373;PF09379;PF00595;PF00102; Q9WU22 CHOYP_PTPN4.1.1 m.15920 sp PTN4_MOUSE 64.706 425 134 6 570 988 506 920 0 583 PTN4_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Testis-enriched protein tyrosine phosphatase) Ptpn4 Mus musculus (Mouse) 926 0 GO:0004726; GO:0005737; GO:0005856; GO:0009898 0 0 0 PF08736;PF09380;PF00373;PF09379;PF00595;PF00102; Q9WU70 CHOYP_STXB5.2.2 m.59975 sp STXB5_RAT 55.556 720 278 13 21 724 31 724 0 815 STXB5_RAT reviewed Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1) Stxbp5 Llgl3 Rattus norvegicus (Rat) 1152 exocytosis [GO:0006887]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of blood coagulation [GO:0030193]; regulation of gene expression [GO:0010468]; regulation of protein secretion [GO:0050708] GO:0005096; GO:0005886; GO:0006887; GO:0008021; GO:0010468; GO:0015031; GO:0016021; GO:0017075; GO:0017137; GO:0030054; GO:0030141; GO:0030193; GO:0030659; GO:0031201; GO:0045921; GO:0050708 0 0 0 PF08596;PF08366;PF00400; Q9WUA2 CHOYP_NEMVEDRAFT_V1G188942.1.1 m.6629 sp SYFB_MOUSE 61.591 591 215 4 1 581 1 589 0 750 SYFB_MOUSE reviewed Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) Farsb Farsl Farslb Frsb Mus musculus (Mouse) 589 phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290] GO:0000287; GO:0003723; GO:0004826; GO:0005524; GO:0006432; GO:0009328; GO:0016020; GO:0051290 0 0 0 PF03483;PF03484; Q9WUB3 CHOYP_LOC100883864.1.1 m.41791 sp PYGM_MOUSE 72.738 840 229 0 5 844 3 842 0 1299 PYGM_MOUSE reviewed "Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)" Pygm Mus musculus (Mouse) 842 cellular calcium ion homeostasis [GO:0006874]; glycogen catabolic process [GO:0005980]; response to cAMP [GO:0051591]; response to hypoxia [GO:0001666] GO:0001666; GO:0005737; GO:0005980; GO:0006874; GO:0008144; GO:0008184; GO:0016208; GO:0016529; GO:0030018; GO:0030170; GO:0030246; GO:0051591; GO:0070062 0 0 cd04300; PF00343; Q9WUV0 CHOYP_LOC100377892.1.2 m.17108 sp ORC5_MOUSE 57.306 438 182 3 12 447 1 435 0 540 ORC5_MOUSE reviewed Origin recognition complex subunit 5 Orc5 Orc5l Mus musculus (Mouse) 435 DNA replication [GO:0006260] GO:0000784; GO:0000808; GO:0005524; GO:0005634; GO:0005664; GO:0005737; GO:0006260 0 0 0 PF14630; Q9WUV0 CHOYP_RELN.3.4 m.48196 sp ORC5_MOUSE 56.849 438 184 3 39 474 1 435 0 536 ORC5_MOUSE reviewed Origin recognition complex subunit 5 Orc5 Orc5l Mus musculus (Mouse) 435 DNA replication [GO:0006260] GO:0000784; GO:0000808; GO:0005524; GO:0005634; GO:0005664; GO:0005737; GO:0006260 0 0 0 PF14630; Q9WV04 CHOYP_LOC100370673.1.1 m.13161 sp KIF9_MOUSE 52.802 803 358 7 33 831 5 790 0 808 KIF9_MOUSE reviewed Kinesin-like protein KIF9 Kif9 Mus musculus (Mouse) 790 extracellular matrix disassembly [GO:0022617]; microtubule-based movement [GO:0007018]; organelle disassembly [GO:1903008]; regulation of podosome assembly [GO:0071801] GO:0002102; GO:0003777; GO:0005524; GO:0005829; GO:0005871; GO:0005874; GO:0007018; GO:0016887; GO:0022617; GO:0031982; GO:0046983; GO:0071801; GO:1903008 0 0 0 PF00225; Q9WV60 CHOYP_GSK3B.1.1 m.62139 sp GSK3B_MOUSE 79.167 408 78 4 1 401 1 408 0 666 GSK3B_MOUSE reviewed Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) Gsk3b Mus musculus (Mouse) 420 aging [GO:0007568]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in positive regulation of apoptotic process [GO:0044337]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cellular response to dopamine [GO:1903351]; cellular response to erythropoietin [GO:0036018]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-3 [GO:0036016]; cellular response to iron(II) ion [GO:0071282]; cellular response to lithium ion [GO:0071285]; cellular response to mechanical stimulus [GO:0071260]; circadian rhythm [GO:0007623]; cytoskeleton organization [GO:0007010]; epithelial to mesenchymal transition [GO:0001837]; ER overload response [GO:0006983]; establishment of cell polarity [GO:0030010]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fat cell differentiation [GO:0045444]; glycogen metabolic process [GO:0005977]; hippocampus development [GO:0021766]; hypermethylation of CpG island [GO:0044027]; intracellular signal transduction [GO:0035556]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; myoblast fusion [GO:0007520]; myotube differentiation [GO:0014902]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron maturation [GO:0014043]; negative regulation of neuron migration [GO:2001223]; negative regulation of neuron projection development [GO:0010977]; negative regulation of NFAT protein import into nucleus [GO:0051534]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of protein binding [GO:0032091]; negative regulation of protein complex assembly [GO:0031333]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; organ morphogenesis [GO:0009887]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of axon extension [GO:0045773]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron death [GO:1901216]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stem cell differentiation [GO:2000738]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777]; protein export from nucleus [GO:0006611]; protein localization to microtubule [GO:0035372]; protein phosphorylation [GO:0006468]; re-entry into mitotic cell cycle [GO:0000320]; regulation of gene expression by genetic imprinting [GO:0006349]; regulation of microtubule-based process [GO:0032886]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of neuron projection development [GO:0010975]; response to activity [GO:0014823]; response to angiotensin [GO:1990776]; response to drug [GO:0042493]; response to epinephrine [GO:0071871]; response to estradiol [GO:0032355]; response to insulin [GO:0032868]; response to insulin-like growth factor stimulus [GO:1990418]; response to L-glutamate [GO:1902065]; response to ultrasound [GO:1990478]; superior temporal gyrus development [GO:0071109]; Wnt signaling pathway [GO:0016055] GO:0000320; GO:0001085; GO:0001837; GO:0001954; GO:0002039; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005813; GO:0005829; GO:0005886; GO:0005977; GO:0006349; GO:0006468; GO:0006611; GO:0006983; GO:0007010; GO:0007409; GO:0007520; GO:0007568; GO:0007623; GO:0008013; GO:0008283; GO:0009887; GO:0010614; GO:0010628; GO:0010800; GO:0010918; GO:0010975; GO:0010977; GO:0014043; GO:0014069; GO:0014823; GO:0014902; GO:0016020; GO:0016055; GO:0016301; GO:0016310; GO:0016477; GO:0018105; GO:0018107; GO:0019901; GO:0021766; GO:0030010; GO:0030424; GO:0030426; GO:0030529; GO:0030877; GO:0031333; GO:0031334; GO:0031625; GO:0032091; GO:0032092; GO:0032355; GO:0032436; GO:0032868; GO:0032886; GO:0033138; GO:0034236; GO:0034392; GO:0035372; GO:0035556; GO:0035729; GO:0036016; GO:0036018; GO:0042493; GO:0043025; GO:0043066; GO:0043197; GO:0043198; GO:0043227; GO:0043407; GO:0043525; GO:0043547; GO:0044027; GO:0044297; GO:0044337; GO:0045121; GO:0045444; GO:0045773; GO:0045944; GO:0046777; GO:0046827; GO:0048168; GO:0048471; GO:0048661; GO:0050321; GO:0050774; GO:0051001; GO:0051059; GO:0051534; GO:0060070; GO:0070059; GO:0070301; GO:0071109; GO:0071260; GO:0071282; GO:0071285; GO:0071871; GO:0097192; GO:1901030; GO:1901216; GO:1902065; GO:1903351; GO:1904339; GO:1990418; GO:1990478; GO:1990776; GO:1990909; GO:2000463; GO:2000573; GO:2000727; GO:2000738; GO:2001223 0 0 0 PF00069; Q9WVR3 CHOYP_SHIP2.1.1 m.23578 sp SHIP2_RAT 38.529 911 504 16 45 935 21 895 0 592 SHIP2_RAT reviewed "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2)" Inppl1 Ship2 Rattus norvegicus (Rat) 1257 brain development [GO:0007420]; cell adhesion [GO:0007155]; endochondral ossification [GO:0001958]; immune system process [GO:0002376]; inositol trisphosphate metabolic process [GO:0032957]; negative regulation of DNA replication [GO:0008156]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; phosphatidylinositol dephosphorylation [GO:0046856]; response to drug [GO:0042493] GO:0001958; GO:0002376; GO:0004445; GO:0005547; GO:0005829; GO:0005856; GO:0007155; GO:0007420; GO:0008156; GO:0010642; GO:0010977; GO:0016020; GO:0030027; GO:0030175; GO:0032957; GO:0042493; GO:0043407; GO:0043569; GO:0046627; GO:0046856 0 0 0 PF03372;PF00536;PF00017; Q9XSC3 CHOYP_WDR44.1.1 m.57080 sp WDR44_BOVIN 54.66 633 220 14 434 1024 299 906 0 672 WDR44_BOVIN reviewed WD repeat-containing protein 44 (Rab11-binding protein) (Rabphilin-11) WDR44 RAB11BP Bos taurus (Bovine) 912 0 GO:0005794; GO:0005829; GO:0010008; GO:0048471 0 0 0 PF00400; Q9XWZ2 CHOYP_LOC100711593.1.1 m.8514 sp ACD11_CAEEL 48.727 589 289 7 40 616 23 610 0 555 ACD11_CAEEL reviewed Acyl-CoA dehydrogenase family member 11 (EC 1.3.99.-) acdh-11 Y45F3A.3 Caenorhabditis elegans 617 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088] GO:0000062; GO:0003995; GO:0005739; GO:0009055; GO:0033539; GO:0050660; GO:0052890; GO:0055088 0 0 0 PF00441;PF02770; Q9Y113 CHOYP_NELFB.1.2 m.9922 sp NELFB_DROME 57.366 577 235 3 2 567 13 589 0 679 NELFB_DROME reviewed Negative elongation factor B NELF-B CG32721 Drosophila melanogaster (Fruit fly) 594 "negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter during mitosis [GO:0007070]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003723; GO:0005634; GO:0005694; GO:0006351; GO:0007070; GO:0017053; GO:0032021; GO:0034244; GO:0045944 0 0 0 PF06209; Q9Y238 CHOYP_LOC100366606.1.2 m.47289 sp DLEC1_HUMAN 35.175 1774 996 30 6 1719 70 1749 0 1013 DLEC1_HUMAN reviewed Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1) DLEC1 DLC1 Homo sapiens (Human) 1755 negative regulation of cell proliferation [GO:0008285] GO:0005737; GO:0008285 0 0 0 0 Q9Y238 CHOYP_LOC100366606.2.2 m.51324 sp DLEC1_HUMAN 35.547 1747 993 30 1 1687 76 1749 0 1010 DLEC1_HUMAN reviewed Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1) DLEC1 DLC1 Homo sapiens (Human) 1755 negative regulation of cell proliferation [GO:0008285] GO:0005737; GO:0008285 0 0 0 0 Q9Y297 CHOYP_BTRC.1.1 m.816 sp FBW1A_HUMAN 79.92 498 84 4 33 528 121 604 0 833 FBW1A_HUMAN reviewed F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) BTRC BTRCP FBW1A FBXW1A Homo sapiens (Human) 605 "branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to organic cyclic compound [GO:0071407]; Fc-epsilon receptor signaling pathway [GO:0038095]; G2/M transition of mitotic cell cycle [GO:0000086]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription, DNA-templated [GO:0045892]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of proteolysis [GO:0045862]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of circadian rhythm [GO:0042752]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of proteasomal protein catabolic process [GO:0061136]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]; Wnt signaling pathway [GO:0016055]" GO:0000086; GO:0000209; GO:0002223; GO:0004842; GO:0005654; GO:0005829; GO:0006470; GO:0006511; GO:0007165; GO:0008013; GO:0016032; GO:0016055; GO:0016567; GO:0016874; GO:0019005; GO:0031146; GO:0031648; GO:0033598; GO:0038061; GO:0038095; GO:0042752; GO:0042753; GO:0043122; GO:0043161; GO:0043433; GO:0045862; GO:0045879; GO:0045892; GO:0045893; GO:0048511; GO:0050852; GO:0051403; GO:0051437; GO:0060444; GO:0060828; GO:0061136; GO:0061630; GO:0071407 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12125;PF12937;PF00400; Q9Y297 CHOYP_BTRC.1.1 m.817 sp FBW1A_HUMAN 79.719 498 85 4 26 521 121 604 0 828 FBW1A_HUMAN reviewed F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) BTRC BTRCP FBW1A FBXW1A Homo sapiens (Human) 605 "branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to organic cyclic compound [GO:0071407]; Fc-epsilon receptor signaling pathway [GO:0038095]; G2/M transition of mitotic cell cycle [GO:0000086]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription, DNA-templated [GO:0045892]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of proteolysis [GO:0045862]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of circadian rhythm [GO:0042752]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of proteasomal protein catabolic process [GO:0061136]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]; Wnt signaling pathway [GO:0016055]" GO:0000086; GO:0000209; GO:0002223; GO:0004842; GO:0005654; GO:0005829; GO:0006470; GO:0006511; GO:0007165; GO:0008013; GO:0016032; GO:0016055; GO:0016567; GO:0016874; GO:0019005; GO:0031146; GO:0031648; GO:0033598; GO:0038061; GO:0038095; GO:0042752; GO:0042753; GO:0043122; GO:0043161; GO:0043433; GO:0045862; GO:0045879; GO:0045892; GO:0045893; GO:0048511; GO:0050852; GO:0051403; GO:0051437; GO:0060444; GO:0060828; GO:0061136; GO:0061630; GO:0071407 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12125;PF12937;PF00400; Q9Y297 CHOYP_EIF3C.1.1 m.7992 sp FBW1A_HUMAN 79.92 498 84 4 33 528 121 604 0 833 FBW1A_HUMAN reviewed F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) BTRC BTRCP FBW1A FBXW1A Homo sapiens (Human) 605 "branching involved in mammary gland duct morphogenesis [GO:0060444]; cellular response to organic cyclic compound [GO:0071407]; Fc-epsilon receptor signaling pathway [GO:0038095]; G2/M transition of mitotic cell cycle [GO:0000086]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription, DNA-templated [GO:0045892]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of proteolysis [GO:0045862]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of circadian rhythm [GO:0042752]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of proteasomal protein catabolic process [GO:0061136]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress-activated MAPK cascade [GO:0051403]; T cell receptor signaling pathway [GO:0050852]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]; Wnt signaling pathway [GO:0016055]" GO:0000086; GO:0000209; GO:0002223; GO:0004842; GO:0005654; GO:0005829; GO:0006470; GO:0006511; GO:0007165; GO:0008013; GO:0016032; GO:0016055; GO:0016567; GO:0016874; GO:0019005; GO:0031146; GO:0031648; GO:0033598; GO:0038061; GO:0038095; GO:0042752; GO:0042753; GO:0043122; GO:0043161; GO:0043433; GO:0045862; GO:0045879; GO:0045892; GO:0045893; GO:0048511; GO:0050852; GO:0051403; GO:0051437; GO:0060444; GO:0060828; GO:0061136; GO:0061630; GO:0071407 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12125;PF12937;PF00400; Q9Y2D4 CHOYP_EXC6B.1.1 m.38489 sp EXC6B_HUMAN 57.726 809 329 5 31 831 8 811 0 964 EXC6B_HUMAN reviewed Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) EXOC6B KIAA0919 SEC15B SEC15L2 Homo sapiens (Human) 811 protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904] GO:0000145; GO:0006904; GO:0015031 0 0 0 PF04091; Q9Y2E4 CHOYP_LOC100117775.1.2 m.16423 sp DIP2C_HUMAN 62.619 1573 561 12 2 1564 1 1556 0 1941 DIP2C_HUMAN reviewed Disco-interacting protein 2 homolog C (DIP2 homolog C) DIP2C KIAA0934 Homo sapiens (Human) 1556 metabolic process [GO:0008152] GO:0003824; GO:0008152 0 0 0 PF00501;PF06464; Q9Y2E4 CHOYP_LOC100117775.2.2 m.59969 sp DIP2C_HUMAN 61.741 1597 550 17 2 1578 1 1556 0 1919 DIP2C_HUMAN reviewed Disco-interacting protein 2 homolog C (DIP2 homolog C) DIP2C KIAA0934 Homo sapiens (Human) 1556 metabolic process [GO:0008152] GO:0003824; GO:0008152 0 0 0 PF00501;PF06464; Q9Y2G3 CHOYP_LOC101173537.1.1 m.20188 sp AT11B_HUMAN 51.18 1102 487 13 67 1128 2 1092 0 1114 AT11B_HUMAN reviewed Probable phospholipid-transporting ATPase IF (EC 3.6.3.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B) ATP11B ATPIF ATPIR KIAA0956 Homo sapiens (Human) 1177 aminophospholipid transport [GO:0015917]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; phospholipid translocation [GO:0045332] GO:0000287; GO:0004012; GO:0005524; GO:0005637; GO:0005769; GO:0005783; GO:0005794; GO:0005886; GO:0006811; GO:0015075; GO:0015917; GO:0016020; GO:0016021; GO:0034220; GO:0045332; GO:0055037; GO:0055038 0 0 0 PF00122;PF16212;PF16209; Q9Y2H1 CHOYP_ISCW_ISCW017707.1.1 m.58329 sp ST38L_HUMAN 74.725 455 104 1 11 465 13 456 0 727 ST38L_HUMAN reviewed Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) STK38L KIAA0965 NDR2 Homo sapiens (Human) 464 intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of cellular component organization [GO:0051128] GO:0000287; GO:0004674; GO:0005524; GO:0005737; GO:0006468; GO:0015629; GO:0016020; GO:0018105; GO:0035556; GO:0051128 0 0 0 PF00069;PF00433; Q9Y2K6 CHOYP_UBP20.2.2 m.51412 sp UBP20_HUMAN 47.671 923 383 16 8 869 8 891 0 872 UBP20_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) USP20 KIAA1003 LSFR3A VDU2 Homo sapiens (Human) 914 endocytosis [GO:0006897]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001664; GO:0004197; GO:0004843; GO:0005813; GO:0006511; GO:0006897; GO:0008270; GO:0008277; GO:0016579; GO:0048471; GO:0070536; GO:0071108 0 0 0 PF06337;PF00443;PF02148; Q9Y2L5 CHOYP_TPPC8.1.1 m.6302 sp TPPC8_HUMAN 41.557 1516 750 36 1 1461 1 1435 0 1093 TPPC8_HUMAN reviewed Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) TRAPPC8 KIAA1012 Homo sapiens (Human) 1435 autophagosome assembly [GO:0000045]; CVT pathway [GO:0032258]; ER to Golgi vesicle-mediated transport [GO:0006888]; nucleophagy [GO:0044804]; pexophagy [GO:0030242]; protein localization to pre-autophagosomal structure [GO:0034497] GO:0000045; GO:0000407; GO:0006888; GO:0030242; GO:0031410; GO:0032258; GO:0034497; GO:0044804; GO:1990072 0 0 0 PF12739; Q9Y2Q0 CHOYP_AT8A1.1.2 m.4062 sp AT8A1_HUMAN 59.967 1199 425 10 24 1204 1 1162 0 1462 AT8A1_HUMAN reviewed Phospholipid-transporting ATPase IA (EC 3.6.3.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) ATP8A1 ATPIA Homo sapiens (Human) 1164 Golgi vesicle budding [GO:0048194]; ion transmembrane transport [GO:0034220]; learning [GO:0007612]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092] GO:0000139; GO:0000287; GO:0004012; GO:0005524; GO:0005783; GO:0005794; GO:0005802; GO:0005886; GO:0007612; GO:0016020; GO:0016021; GO:0019829; GO:0030335; GO:0034220; GO:0042584; GO:0043231; GO:0045332; GO:0048194; GO:0061092; GO:0070062 0 0 0 PF00122;PF16212;PF16209; Q9Y2Q0 CHOYP_AT8A1.2.2 m.40652 sp AT8A1_HUMAN 61.106 1175 426 9 35 1191 1 1162 0 1474 AT8A1_HUMAN reviewed Phospholipid-transporting ATPase IA (EC 3.6.3.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) ATP8A1 ATPIA Homo sapiens (Human) 1164 Golgi vesicle budding [GO:0048194]; ion transmembrane transport [GO:0034220]; learning [GO:0007612]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092] GO:0000139; GO:0000287; GO:0004012; GO:0005524; GO:0005783; GO:0005794; GO:0005802; GO:0005886; GO:0007612; GO:0016020; GO:0016021; GO:0019829; GO:0030335; GO:0034220; GO:0042584; GO:0043231; GO:0045332; GO:0048194; GO:0061092; GO:0070062 0 0 0 PF00122;PF16212;PF16209; Q9Y2V7 CHOYP_COG6.1.1 m.57008 sp COG6_HUMAN 63.125 640 229 3 5 642 22 656 0 863 COG6_HUMAN reviewed Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) COG6 KIAA1134 Homo sapiens (Human) 657 ER to Golgi vesicle-mediated transport [GO:0006888]; glycosylation [GO:0070085]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031] GO:0000139; GO:0006888; GO:0006891; GO:0015031; GO:0017119; GO:0032588; GO:0070085 0 0 0 0 Q9Y2X7 CHOYP_GIT1.1.2 m.26059 sp GIT1_HUMAN 49.746 786 312 16 1 735 1 754 0 648 GIT1_HUMAN reviewed ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) GIT1 Homo sapiens (Human) 761 ephrin receptor signaling pathway [GO:0048013]; regulation of cytokinesis [GO:0032465]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0005096; GO:0005737; GO:0005829; GO:0005925; GO:0008277; GO:0016020; GO:0016235; GO:0032465; GO:0046872; GO:0048013 0 0 0 PF12796;PF01412;PF12205;PF16559;PF08518; Q9Y2X7 CHOYP_GIT1.2.2 m.56285 sp GIT1_HUMAN 48.044 818 313 17 1 770 1 754 0 638 GIT1_HUMAN reviewed ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) GIT1 Homo sapiens (Human) 761 ephrin receptor signaling pathway [GO:0048013]; regulation of cytokinesis [GO:0032465]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0005096; GO:0005737; GO:0005829; GO:0005925; GO:0008277; GO:0016020; GO:0016235; GO:0032465; GO:0046872; GO:0048013 0 0 0 PF12796;PF01412;PF12205;PF16559;PF08518; Q9Y345 CHOYP_AT1.1.1 m.66793 sp SC6A5_HUMAN 46.815 628 288 13 4 623 187 776 0 544 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y345 CHOYP_LOC100367341.1.1 m.12409 sp SC6A5_HUMAN 49.832 594 288 2 39 632 183 766 0 637 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y345 CHOYP_SC6A5.1.7 m.8706 sp SC6A5_HUMAN 48.02 606 297 7 51 650 173 766 0 591 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y345 CHOYP_SC6A5.2.7 m.13689 sp SC6A5_HUMAN 49.421 605 284 6 1 595 177 769 0 582 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y345 CHOYP_SC6A5.3.7 m.20491 sp SC6A5_HUMAN 46.166 639 304 12 13 643 175 781 0 547 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y345 CHOYP_SC6A9.1.6 m.2679 sp SC6A5_HUMAN 46.98 596 289 7 2 578 185 772 0 561 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y366 CHOYP_LOC100367604.1.1 m.52334 sp IFT52_HUMAN 65.501 429 143 2 52 475 2 430 0 588 IFT52_HUMAN reviewed Intraflagellar transport protein 52 homolog (Protein NGD5 homolog) IFT52 C20orf9 NGD5 CGI-53 Homo sapiens (Human) 437 cilium morphogenesis [GO:0060271]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; negative regulation of epithelial cell proliferation [GO:0050680]; neural tube formation [GO:0001841]; regulation of protein processing [GO:0070613]; smoothened signaling pathway [GO:0007224] GO:0001841; GO:0001947; GO:0005814; GO:0007224; GO:0008022; GO:0009953; GO:0030992; GO:0031514; GO:0032391; GO:0042733; GO:0044292; GO:0050680; GO:0060271; GO:0070613; GO:0072372; GO:0097542; GO:0097546 0 0 0 PF09822; Q9Y3Q0 CHOYP_LOC579656.1.5 m.14095 sp NALD2_HUMAN 45.368 734 375 13 37 761 23 739 0 631 NALD2_HUMAN reviewed N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) 740 cellular amino acid biosynthetic process [GO:0008652]; neurotransmitter catabolic process [GO:0042135]; proteolysis [GO:0006508] GO:0004180; GO:0005886; GO:0006508; GO:0008236; GO:0008237; GO:0008239; GO:0008652; GO:0016021; GO:0016805; GO:0042135; GO:0046872; GO:0050129 0 0 0 PF02225;PF04389;PF04253; Q9Y3Q0 CHOYP_LOC579656.2.5 m.27917 sp NALD2_HUMAN 45.093 754 386 13 1 743 3 739 0 649 NALD2_HUMAN reviewed N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) 740 cellular amino acid biosynthetic process [GO:0008652]; neurotransmitter catabolic process [GO:0042135]; proteolysis [GO:0006508] GO:0004180; GO:0005886; GO:0006508; GO:0008236; GO:0008237; GO:0008239; GO:0008652; GO:0016021; GO:0016805; GO:0042135; GO:0046872; GO:0050129 0 0 0 PF02225;PF04389;PF04253; Q9Y3Q0 CHOYP_LOC579656.3.5 m.41908 sp NALD2_HUMAN 44.415 752 391 14 9 752 7 739 0 621 NALD2_HUMAN reviewed N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) 740 cellular amino acid biosynthetic process [GO:0008652]; neurotransmitter catabolic process [GO:0042135]; proteolysis [GO:0006508] GO:0004180; GO:0005886; GO:0006508; GO:0008236; GO:0008237; GO:0008239; GO:0008652; GO:0016021; GO:0016805; GO:0042135; GO:0046872; GO:0050129 0 0 0 PF02225;PF04389;PF04253; Q9Y3Q0 CHOYP_LOC579656.4.5 m.57067 sp NALD2_HUMAN 44.065 733 385 12 37 760 23 739 0 615 NALD2_HUMAN reviewed N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) NAALAD2 Homo sapiens (Human) 740 cellular amino acid biosynthetic process [GO:0008652]; neurotransmitter catabolic process [GO:0042135]; proteolysis [GO:0006508] GO:0004180; GO:0005886; GO:0006508; GO:0008236; GO:0008237; GO:0008239; GO:0008652; GO:0016021; GO:0016805; GO:0042135; GO:0046872; GO:0050129 0 0 0 PF02225;PF04389;PF04253; Q9Y450 CHOYP_HBS1L.1.2 m.14311 sp HBS1L_HUMAN 49.044 732 310 10 1 719 1 682 0 682 HBS1L_HUMAN reviewed HBS1-like protein (ERFS) HBS1L HBS1 KIAA1038 Homo sapiens (Human) 684 ribosome disassembly [GO:0032790]; signal transduction [GO:0007165]; translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0006412; GO:0007165; GO:0016020; GO:0032790; GO:0070062 0 0 0 PF03144;PF03143;PF08938; Q9Y490 CHOYP_LOC100742957.1.1 m.48383 sp TLN1_HUMAN 52.841 704 289 8 1 700 1 665 0 755 TLN1_HUMAN reviewed Talin-1 TLN1 KIAA1027 TLN Homo sapiens (Human) 2541 cell-cell junction assembly [GO:0007043]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeletal anchoring at plasma membrane [GO:0007016]; IRE1-mediated unfolded protein response [GO:0036498]; movement of cell or subcellular component [GO:0006928]; muscle contraction [GO:0006936]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; viral process [GO:0016032] GO:0001726; GO:0002576; GO:0005178; GO:0005200; GO:0005576; GO:0005737; GO:0005815; GO:0005829; GO:0005886; GO:0005911; GO:0005913; GO:0005925; GO:0006928; GO:0006936; GO:0007016; GO:0007043; GO:0007044; GO:0009986; GO:0016032; GO:0017166; GO:0030274; GO:0030866; GO:0032587; GO:0036498; GO:0070062; GO:0070527; GO:0098641 0 0 0 PF16511;PF00373;PF09379;PF01608;PF09141;PF08913; Q9Y490 CHOYP_TLN1.4.4 m.33719 sp TLN1_HUMAN 57.796 2559 1041 15 1 2548 1 2531 0 2836 TLN1_HUMAN reviewed Talin-1 TLN1 KIAA1027 TLN Homo sapiens (Human) 2541 cell-cell junction assembly [GO:0007043]; cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeletal anchoring at plasma membrane [GO:0007016]; IRE1-mediated unfolded protein response [GO:0036498]; movement of cell or subcellular component [GO:0006928]; muscle contraction [GO:0006936]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; viral process [GO:0016032] GO:0001726; GO:0002576; GO:0005178; GO:0005200; GO:0005576; GO:0005737; GO:0005815; GO:0005829; GO:0005886; GO:0005911; GO:0005913; GO:0005925; GO:0006928; GO:0006936; GO:0007016; GO:0007043; GO:0007044; GO:0009986; GO:0016032; GO:0017166; GO:0030274; GO:0030866; GO:0032587; GO:0036498; GO:0070062; GO:0070527; GO:0098641 0 0 0 PF16511;PF00373;PF09379;PF01608;PF09141;PF08913; Q9Y4A5 CHOYP_LOC100123553.1.1 m.34041 sp TRRAP_HUMAN 62.815 3254 1112 27 1 3186 76 3299 0 4179 TRRAP_HUMAN reviewed Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) TRRAP PAF400 Homo sapiens (Human) 3859 "beta-catenin-TCF complex assembly [GO:1904837]; DNA repair [GO:0006281]; histone acetylation [GO:0016573]; histone deubiquitination [GO:0016578]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000125; GO:0000812; GO:0003712; GO:0005634; GO:0005654; GO:0005794; GO:0006281; GO:0006351; GO:0006355; GO:0016301; GO:0016573; GO:0016578; GO:0030914; GO:0033276; GO:0035267; GO:0043967; GO:0043968; GO:1904837 0 0 0 PF02259;PF00454; Q9Y4B6 CHOYP_VPRBP.1.1 m.15849 sp VPRBP_HUMAN 47.25 1418 665 27 4 1370 8 1393 0 1248 VPRBP_HUMAN reviewed Protein VPRBP (DDB1- and CUL4-associated factor 1) (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein) VPRBP DCAF1 KIAA0800 RIP Homo sapiens (Human) 1507 "B cell differentiation [GO:0030183]; cell competition in a multicellular organism [GO:0035212]; histone H2A-T120 phosphorylation [GO:1990245]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; transcription, DNA-templated [GO:0006351]; V(D)J recombination [GO:0033151]; viral process [GO:0016032]" GO:0000122; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0006351; GO:0016032; GO:0016567; GO:0030183; GO:0033151; GO:0035212; GO:1990244; GO:1990245 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q9Y4C8 CHOYP_RBM19.1.2 m.28228 sp RBM19_HUMAN 45.808 978 444 17 1 928 1 942 0 805 RBM19_HUMAN reviewed Probable RNA-binding protein 19 (RNA-binding motif protein 19) RBM19 KIAA0682 Homo sapiens (Human) 960 multicellular organism development [GO:0007275]; positive regulation of embryonic development [GO:0040019] GO:0000166; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0007275; GO:0016020; GO:0040019; GO:0044822 0 0 0 PF00076; Q9Y4D8 CHOYP_RGD1309762.1.1 m.47917 sp HECD4_HUMAN 48.515 3164 1369 57 406 3472 13 3013 0 2793 HECD4_HUMAN reviewed Probable E3 ubiquitin-protein ligase HECTD4 (EC 2.3.2.26) (HECT domain-containing protein 4) (HECT-type E3 ubiquitin transferase HECTD4) HECTD4 C12orf51 KIAA0614 Homo sapiens (Human) 3996 glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005737; GO:0006006; GO:0016021; GO:0016874; GO:0042593; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q9Y4G6 CHOYP_TLN2.1.2 m.5591 sp TLN2_HUMAN 60.228 1051 406 4 966 2015 1492 2531 0 1187 TLN2_HUMAN reviewed Talin-2 TLN2 KIAA0320 Homo sapiens (Human) 2542 cell adhesion [GO:0007155]; cell-cell junction assembly [GO:0007043]; cytoskeletal anchoring at plasma membrane [GO:0007016] GO:0001726; GO:0003779; GO:0005198; GO:0005200; GO:0005737; GO:0005886; GO:0005911; GO:0005925; GO:0007016; GO:0007043; GO:0007155; GO:0015629; GO:0045202 0 0 0 PF16511;PF00373;PF09379;PF01608;PF09141;PF08913; Q9Y4I1 CHOYP_MYO5A.1.4 m.5224 sp MYO5A_HUMAN 53.365 1902 777 25 1 1839 1 1855 0 1952 MYO5A_HUMAN reviewed "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)" MYO5A MYH12 Homo sapiens (Human) 1855 "actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; chemical synaptic transmission [GO:0007268]; endoplasmic reticulum localization [GO:0051643]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; locomotion involved in locomotory behavior [GO:0031987]; long-chain fatty acid biosynthetic process [GO:0042759]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; melanosome transport [GO:0032402]; myelination [GO:0042552]; odontogenesis [GO:0042476]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; secretory granule localization [GO:0032252]; synapse organization [GO:0050808]; transport [GO:0006810]; vesicle-mediated transport [GO:0016192]; vesicle transport along actin filament [GO:0030050]; visual perception [GO:0007601]" GO:0000146; GO:0001726; GO:0001750; GO:0005509; GO:0005524; GO:0005737; GO:0005794; GO:0005829; GO:0005882; GO:0006810; GO:0006887; GO:0006892; GO:0007268; GO:0007601; GO:0016020; GO:0016192; GO:0016459; GO:0017137; GO:0030048; GO:0030050; GO:0030073; GO:0030318; GO:0030426; GO:0031585; GO:0031987; GO:0032252; GO:0032402; GO:0032433; GO:0032593; GO:0032869; GO:0035371; GO:0042438; GO:0042470; GO:0042476; GO:0042552; GO:0042641; GO:0042759; GO:0043005; GO:0043025; GO:0044822; GO:0050808; GO:0051643; GO:0070062; GO:0072659 0 0 0 PF01843;PF00612;PF00063; Q9Y4I1 CHOYP_MYO5A.2.4 m.11575 sp MYO5A_HUMAN 51.634 1958 789 28 18 1923 4 1855 0 1908 MYO5A_HUMAN reviewed "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)" MYO5A MYH12 Homo sapiens (Human) 1855 "actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; chemical synaptic transmission [GO:0007268]; endoplasmic reticulum localization [GO:0051643]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; locomotion involved in locomotory behavior [GO:0031987]; long-chain fatty acid biosynthetic process [GO:0042759]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; melanosome transport [GO:0032402]; myelination [GO:0042552]; odontogenesis [GO:0042476]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; secretory granule localization [GO:0032252]; synapse organization [GO:0050808]; transport [GO:0006810]; vesicle-mediated transport [GO:0016192]; vesicle transport along actin filament [GO:0030050]; visual perception [GO:0007601]" GO:0000146; GO:0001726; GO:0001750; GO:0005509; GO:0005524; GO:0005737; GO:0005794; GO:0005829; GO:0005882; GO:0006810; GO:0006887; GO:0006892; GO:0007268; GO:0007601; GO:0016020; GO:0016192; GO:0016459; GO:0017137; GO:0030048; GO:0030050; GO:0030073; GO:0030318; GO:0030426; GO:0031585; GO:0031987; GO:0032252; GO:0032402; GO:0032433; GO:0032593; GO:0032869; GO:0035371; GO:0042438; GO:0042470; GO:0042476; GO:0042552; GO:0042641; GO:0042759; GO:0043005; GO:0043025; GO:0044822; GO:0050808; GO:0051643; GO:0070062; GO:0072659 0 0 0 PF01843;PF00612;PF00063; Q9Y4I1 CHOYP_MYO5A.3.4 m.42609 sp MYO5A_HUMAN 51.797 1948 786 27 18 1908 4 1855 0 1917 MYO5A_HUMAN reviewed "Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myosin-12) (Myoxin)" MYO5A MYH12 Homo sapiens (Human) 1855 "actin filament-based movement [GO:0030048]; cellular response to insulin stimulus [GO:0032869]; chemical synaptic transmission [GO:0007268]; endoplasmic reticulum localization [GO:0051643]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; locomotion involved in locomotory behavior [GO:0031987]; long-chain fatty acid biosynthetic process [GO:0042759]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; melanosome transport [GO:0032402]; myelination [GO:0042552]; odontogenesis [GO:0042476]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to plasma membrane [GO:0072659]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; secretory granule localization [GO:0032252]; synapse organization [GO:0050808]; transport [GO:0006810]; vesicle-mediated transport [GO:0016192]; vesicle transport along actin filament [GO:0030050]; visual perception [GO:0007601]" GO:0000146; GO:0001726; GO:0001750; GO:0005509; GO:0005524; GO:0005737; GO:0005794; GO:0005829; GO:0005882; GO:0006810; GO:0006887; GO:0006892; GO:0007268; GO:0007601; GO:0016020; GO:0016192; GO:0016459; GO:0017137; GO:0030048; GO:0030050; GO:0030073; GO:0030318; GO:0030426; GO:0031585; GO:0031987; GO:0032252; GO:0032402; GO:0032433; GO:0032593; GO:0032869; GO:0035371; GO:0042438; GO:0042470; GO:0042476; GO:0042552; GO:0042641; GO:0042759; GO:0043005; GO:0043025; GO:0044822; GO:0050808; GO:0051643; GO:0070062; GO:0072659 0 0 0 PF01843;PF00612;PF00063; Q9Y4K4 CHOYP_LOC100864577.1.1 m.8977 sp M4K5_HUMAN 55.981 861 339 14 11 856 11 846 0 961 M4K5_HUMAN reviewed Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) MAP4K5 Homo sapiens (Human) 846 activation of JUN kinase activity [GO:0007257]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0006468; GO:0007257; GO:0008349; GO:0035556 0 0 0 PF00780;PF00069; Q9Y4W6 CHOYP_AFG32.1.1 m.59372 sp AFG32_HUMAN 60.502 638 238 7 170 795 145 780 0 756 AFG32_HUMAN reviewed AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein) AFG3L2 Homo sapiens (Human) 797 axonogenesis [GO:0007409]; cristae formation [GO:0042407]; mitochondrial fusion [GO:0008053]; mitochondrial protein processing [GO:0034982]; muscle fiber development [GO:0048747]; myelination [GO:0042552]; nerve development [GO:0021675]; neuromuscular junction development [GO:0007528]; protein complex assembly [GO:0006461]; protein import into mitochondrial intermembrane space [GO:0045041]; regulation of multicellular organism growth [GO:0040014]; righting reflex [GO:0060013] GO:0004176; GO:0004222; GO:0005524; GO:0005739; GO:0005743; GO:0006461; GO:0007409; GO:0007528; GO:0008053; GO:0008237; GO:0008270; GO:0016021; GO:0021675; GO:0034982; GO:0040014; GO:0042407; GO:0042552; GO:0045041; GO:0048747; GO:0051082; GO:0060013 0 0 0 PF00004;PF06480;PF01434; Q9Y597 CHOYP_KCTD3.1.1 m.55149 sp KCTD3_HUMAN 61.743 677 209 6 3 677 17 645 0 827 KCTD3_HUMAN reviewed BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45) KCTD3 Homo sapiens (Human) 815 protein homooligomerization [GO:0051260] GO:0051260 0 0 0 PF02214; Q9Y5L0 CHOYP_TNPO3.1.1 m.11099 sp TNPO3_HUMAN 55.987 927 401 4 3 929 4 923 0 1075 TNPO3_HUMAN reviewed Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR) TNPO3 IPO12 Homo sapiens (Human) 923 splicing factor protein import into nucleus [GO:0035048] GO:0004872; GO:0005737; GO:0008139; GO:0008565; GO:0031965; GO:0035048; GO:0042802; GO:0043231 0 0 0 PF08389; Q9Y5W7 CHOYP_BRAFLDRAFT_275391.1.1 m.10168 sp SNX14_HUMAN 43.459 925 474 14 33 947 47 932 0 727 SNX14_HUMAN reviewed Sorting nexin-14 SNX14 Homo sapiens (Human) 946 autophagosome maturation [GO:0097352]; protein transport [GO:0015031] GO:0005764; GO:0005765; GO:0005770; GO:0015031; GO:0016021; GO:0030425; GO:0031902; GO:0035091; GO:0080025; GO:0097352 0 0 0 PF08628;PF00787;PF02194;PF00615; Q9Y600 CHOYP_BRAFLDRAFT_58194.1.1 m.27050 sp CSAD_HUMAN 54.008 474 216 2 23 494 20 493 0 560 CSAD_HUMAN reviewed Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) CSAD CSD Homo sapiens (Human) 493 carboxylic acid metabolic process [GO:0019752]; taurine biosynthetic process [GO:0042412] GO:0004782; GO:0019752; GO:0030170; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. 0 0 PF00282; Q9Y600 CHOYP_GADL1.1.1 m.14433 sp CSAD_HUMAN 52.092 478 227 2 90 565 16 493 0 563 CSAD_HUMAN reviewed Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) CSAD CSD Homo sapiens (Human) 493 carboxylic acid metabolic process [GO:0019752]; taurine biosynthetic process [GO:0042412] GO:0004782; GO:0019752; GO:0030170; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. 0 0 PF00282; Q9Y620 CHOYP_RA54B.1.1 m.9067 sp RA54B_HUMAN 51.274 903 377 22 1 854 1 889 0 859 RA54B_HUMAN reviewed DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B) RAD54B Homo sapiens (Human) 910 determination of adult lifespan [GO:0008340]; double-strand break repair via homologous recombination [GO:0000724]; mitotic recombination [GO:0006312]; reciprocal meiotic recombination [GO:0007131]; response to drug [GO:0042493]; response to ionizing radiation [GO:0010212] GO:0000724; GO:0003677; GO:0003678; GO:0003724; GO:0005524; GO:0005634; GO:0006312; GO:0007131; GO:0008340; GO:0010212; GO:0015616; GO:0042493 0 0 0 PF00271;PF00176; Q9Y6D6 CHOYP_BIG1.2.3 m.7217 sp BIG1_HUMAN 67.17 1855 500 19 1 1764 1 1837 0 2453 BIG1_HUMAN reviewed Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) ARFGEF1 ARFGEP1 BIG1 Homo sapiens (Human) 1849 endomembrane system organization [GO:0010256]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; neuron projection development [GO:0031175]; positive regulation of protein glycosylation in Golgi [GO:0090284]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of wound healing [GO:0090303]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114] GO:0000139; GO:0005085; GO:0005086; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0006887; GO:0007030; GO:0010256; GO:0015031; GO:0016363; GO:0017022; GO:0030532; GO:0030837; GO:0031175; GO:0032012; GO:0034237; GO:0034260; GO:0048471; GO:0051897; GO:0090284; GO:0090303; GO:2000114 0 0 0 PF16213;PF09324;PF01369;PF12783; Q9Y6D6 CHOYP_BIG1.3.3 m.34442 sp BIG1_HUMAN 66.507 1875 495 23 1 1780 1 1837 0 2435 BIG1_HUMAN reviewed Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (ADP-ribosylation factor guanine nucleotide-exchange factor 1) (p200 ARF guanine nucleotide exchange factor) (p200 ARF-GEP1) ARFGEF1 ARFGEP1 BIG1 Homo sapiens (Human) 1849 endomembrane system organization [GO:0010256]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of GTPase activity [GO:0034260]; neuron projection development [GO:0031175]; positive regulation of protein glycosylation in Golgi [GO:0090284]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of wound healing [GO:0090303]; protein transport [GO:0015031]; regulation of ARF protein signal transduction [GO:0032012]; regulation of establishment of cell polarity [GO:2000114] GO:0000139; GO:0005085; GO:0005086; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0006887; GO:0007030; GO:0010256; GO:0015031; GO:0016363; GO:0017022; GO:0030532; GO:0030837; GO:0031175; GO:0032012; GO:0034237; GO:0034260; GO:0048471; GO:0051897; GO:0090284; GO:0090303; GO:2000114 0 0 0 PF16213;PF09324;PF01369;PF12783; Q9Y6I4 CHOYP_UBP3.1.1 m.29854 sp UBP3_HUMAN 53.346 523 208 8 1 495 1 515 0 540 UBP3_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.4.19.12) (Deubiquitinating enzyme 3) (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) USP3 Homo sapiens (Human) 520 DNA repair [GO:0006281]; histone deubiquitination [GO:0016578]; mitotic cell cycle [GO:0000278]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000278; GO:0000790; GO:0004843; GO:0005634; GO:0005737; GO:0006281; GO:0006511; GO:0008270; GO:0016578; GO:0031647; GO:0042393; GO:0043231 0 0 0 PF00443;PF02148; Q9Y6R4 CHOYP_LOC101174856.1.1 m.47585 sp M3K4_HUMAN 39.824 1479 716 35 253 1648 216 1603 0 959 M3K4_HUMAN reviewed Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 Homo sapiens (Human) 1608 activation of MAPKK activity [GO:0000186]; chorionic trophoblast cell differentiation [GO:0060718]; intracellular signal transduction [GO:0035556]; male germ-line sex determination [GO:0019100]; placenta development [GO:0001890]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of gene expression [GO:0010468]; response to UV-C [GO:0010225] GO:0000186; GO:0001890; GO:0004709; GO:0005524; GO:0005737; GO:0010225; GO:0010468; GO:0019100; GO:0032212; GO:0035556; GO:0043507; GO:0046872; GO:0048471; GO:0051973; GO:0060718; GO:1900745; GO:1904355 0 0 0 PF00069; Q9Y6V7 CHOYP_DDX49.1.1 m.10584 sp DDX49_HUMAN 60.271 443 171 2 18 455 4 446 0 566 DDX49_HUMAN reviewed Probable ATP-dependent RNA helicase DDX49 (EC 3.6.4.13) (DEAD box protein 49) DDX49 Homo sapiens (Human) 483 RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364] GO:0004004; GO:0005524; GO:0005654; GO:0006364; GO:0010501; GO:0044822 0 0 0 PF00270;PF00271; Q9Y6X6 CHOYP_MYO16.1.4 m.22525 sp MYO16_HUMAN 34.333 1267 727 23 1 1219 3 1212 0 711 MYO16_HUMAN reviewed Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) MYO16 KIAA0865 MYO16B NYAP3 Homo sapiens (Human) 1858 cerebellum development [GO:0021549]; negative regulation of cell proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134] GO:0003774; GO:0005524; GO:0005654; GO:0005737; GO:0005886; GO:0008285; GO:0016459; GO:0021549; GO:0048471; GO:0051015; GO:2000134 0 0 0 PF12796;PF00063; Q9Y6X6 CHOYP_MYO16.4.4 m.65831 sp MYO16_HUMAN 35.275 1202 699 20 1 1162 3 1165 0 720 MYO16_HUMAN reviewed Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) MYO16 KIAA0865 MYO16B NYAP3 Homo sapiens (Human) 1858 cerebellum development [GO:0021549]; negative regulation of cell proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134] GO:0003774; GO:0005524; GO:0005654; GO:0005737; GO:0005886; GO:0008285; GO:0016459; GO:0021549; GO:0048471; GO:0051015; GO:2000134 0 0 0 PF12796;PF00063; Q9Y6X9 CHOYP_MORC2.1.1 m.6240 sp MORC2_HUMAN 44.85 1068 495 17 1 1027 1 1015 0 871 MORC2_HUMAN reviewed MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled-coil domain protein 1) MORC2 KIAA0852 ZCWCC1 Homo sapiens (Human) 1032 fatty acid metabolic process [GO:0006631] GO:0005634; GO:0005737; GO:0005829; GO:0006631; GO:0008270 0 0 0 PF07496; Q9YGY3 CHOYP_BRAFLDRAFT_125481.1.1 m.4369 sp BUB3_XENLA 77.882 321 69 2 36 355 11 330 0 533 BUB3_XENLA reviewed Mitotic checkpoint protein BUB3 (xbub3) (WD repeat protein Bub3) bub3 Xenopus laevis (African clawed frog) 330 cell division [GO:0051301]; chromosome segregation [GO:0007059]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005634; GO:0007059; GO:0007067; GO:0051301; GO:0051321 0 0 0 PF00400; Q9YH58 CHOYP_BRAFLDRAFT_125780.1.1 m.60450 sp FTCD_CHICK 59.571 559 207 1 52 610 1 540 0 680 FTCD_CHICK reviewed Formimidoyltransferase-cyclodeaminase (Formiminotransferase-cyclodeaminase) (FTCD) (p60) [Includes: Glutamate formimidoyltransferase (EC 2.1.2.5) (Glutamate formiminotransferase) (Glutamate formyltransferase); Formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) (Formiminotetrahydrofolate cyclodeaminase)] FTCD Gallus gallus (Chicken) 541 histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557]; tetrahydrofolate interconversion [GO:0035999] GO:0005542; GO:0005794; GO:0005814; GO:0019556; GO:0019557; GO:0030409; GO:0030412; GO:0035999 PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.; PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. 0 0 PF02971;PF04961;PF07837; Q9YHB5 CHOYP_NCAPG.1.1 m.65111 sp CND3_XENLA 40.419 955 533 9 4 931 10 955 0 670 CND3_XENLA reviewed Condensin complex subunit 3 (Chromosome assembly protein xCAP-G) (Chromosome-associated protein G) (Condensin subunit CAP-G) (Non-SMC condensin I complex subunit G) ncapg capg Xenopus laevis (African clawed frog) 1034 cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] GO:0000796; GO:0005634; GO:0005829; GO:0007076; GO:0051301 0 0 0 PF12719; Q9YHY6 CHOYP_BRAFLDRAFT_283981.1.1 m.7732 sp CND1_XENLA 42.698 1438 715 17 1 1427 1 1340 0 1124 CND1_XENLA reviewed Condensin complex subunit 1 (Chromosome assembly protein XCAP-D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (Eg7) (Non-SMC condensin I complex subunit D2) ncapd2 capd2 cnap1 eg7 Xenopus laevis (African clawed frog) 1364 cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] GO:0005634; GO:0005694; GO:0005829; GO:0007076; GO:0051301 0 0 0 PF12717;PF12922; Q9Z0J4 CHOYP_NOSC.1.1 m.6346 sp NOS1_MOUSE 49.966 1471 668 18 5 1463 14 1428 0 1439 NOS1_MOUSE reviewed "Nitric oxide synthase, brain (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Peptidyl-cysteine S-nitrosylase NOS1) (bNOS)" Nos1 Mus musculus (Mouse) 1429 "aging [GO:0007568]; behavioral response to cocaine [GO:0048148]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mechanical stimulus [GO:0071260]; exogenous drug catabolic process [GO:0042738]; female pregnancy [GO:0007565]; multicellular organismal response to stress [GO:0033555]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of heart contraction [GO:0045822]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of insulin secretion [GO:0046676]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of serotonin uptake [GO:0051612]; negative regulation of vasoconstriction [GO:0045906]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of adrenergic receptor signaling pathway involved in heart process [GO:1901206]; positive regulation of guanylate cyclase activity [GO:0031284]; positive regulation of histone acetylation [GO:0035066]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron death [GO:1901216]; positive regulation of the force of heart contraction [GO:0098735]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of vasodilation [GO:0045909]; regulation of neurogenesis [GO:0050767]; regulation of sensory perception of pain [GO:0051930]; regulation of sodium ion transport [GO:0002028]; response to activity [GO:0014823]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hypoxia [GO:0001666]; response to lead ion [GO:0010288]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nitric oxide [GO:0071731]; response to peptide hormone [GO:0043434]; response to vitamin E [GO:0033197]; striated muscle contraction [GO:0006941]" GO:0001666; GO:0002028; GO:0004517; GO:0005506; GO:0005739; GO:0005741; GO:0005829; GO:0005856; GO:0006809; GO:0006941; GO:0007263; GO:0007565; GO:0007568; GO:0008285; GO:0009408; GO:0010181; GO:0010288; GO:0012506; GO:0014069; GO:0014823; GO:0016529; GO:0018119; GO:0020037; GO:0030018; GO:0030315; GO:0031284; GO:0031965; GO:0032496; GO:0033017; GO:0033197; GO:0033555; GO:0035066; GO:0035094; GO:0042383; GO:0042582; GO:0042738; GO:0043066; GO:0043197; GO:0043267; GO:0043434; GO:0043627; GO:0045121; GO:0045202; GO:0045471; GO:0045776; GO:0045822; GO:0045893; GO:0045906; GO:0045909; GO:0045944; GO:0046676; GO:0048148; GO:0050660; GO:0050661; GO:0050767; GO:0051346; GO:0051481; GO:0051612; GO:0051926; GO:0051930; GO:0071260; GO:0071363; GO:0071731; GO:0098735; GO:1900273; GO:1901206; GO:1901216 0 0 0 PF00667;PF00258;PF00175;PF02898;PF00595; Q9Z0P7 CHOYP_LOC100313743.2.2 m.34329 sp SUFU_MOUSE 58.621 464 163 6 40 490 31 478 0 555 SUFU_MOUSE reviewed Suppressor of fused homolog Sufu Mus musculus (Mouse) 484 aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; cytoplasmic sequestering of transcription factor [GO:0042994]; determination of left/right symmetry [GO:0007368]; heart looping [GO:0001947]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube closure [GO:0001843]; skin development [GO:0043588]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; spinal cord dorsal/ventral patterning [GO:0021513]; ventricular septum development [GO:0003281] GO:0000122; GO:0001843; GO:0001947; GO:0003281; GO:0003714; GO:0004871; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005929; GO:0007368; GO:0008013; GO:0008134; GO:0019901; GO:0021513; GO:0021775; GO:0021776; GO:0035904; GO:0042994; GO:0043433; GO:0043588; GO:0045879; GO:0060976; GO:0072372; GO:1901621; GO:2000059 0 0 0 PF05076;PF12470; Q9Z0W3 CHOYP_NU160.1.1 m.46155 sp NU160_MOUSE 37.326 1436 835 28 12 1421 3 1399 0 867 NU160_MOUSE reviewed Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Gene trap locus 1-13 protein) (GTL-13) (Nucleoporin Nup160) Nup160 Gtl1-13 Kiaa0197 Mus musculus (Mouse) 1402 mRNA export from nucleus [GO:0006406]; protein transport [GO:0015031] GO:0000776; GO:0005487; GO:0005643; GO:0006406; GO:0015031; GO:0031080 0 0 0 0 Q9Z0Y8 CHOYP_LOC100120801.1.1 m.34805 sp CAC1I_RAT 50.12 836 347 11 1 781 41 861 0 740 CAC1I_RAT reviewed Voltage-dependent T-type calcium channel subunit alpha-1I (CaVT.3) (Voltage-gated calcium channel subunit alpha Cav3.3) Cacna1i Rattus norvegicus (Rat) 2201 calcium ion import [GO:0070509]; calcium ion transport into cytosol [GO:0060402]; membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; sperm motility [GO:0030317] GO:0005886; GO:0005891; GO:0008332; GO:0019228; GO:0030317; GO:0045956; GO:0060402; GO:0070509; GO:0086010 0 0 0 PF00520; Q9Z139 CHOYP_LOC100533220.2.2 m.13989 sp ROR1_MOUSE 42.503 847 403 17 75 895 58 846 0 668 ROR1_MOUSE reviewed "Inactive tyrosine-protein kinase transmembrane receptor ROR1 (mROR1) (Neurotrophic tyrosine kinase, receptor-related 1)" Ror1 Ntrkr1 Mus musculus (Mouse) 937 transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; Wnt signaling pathway [GO:0016055] GO:0004714; GO:0005524; GO:0005887; GO:0007169; GO:0016055; GO:0017147; GO:0043235 0 0 0 PF01392;PF07679;PF00051;PF07714; Q9Z160 CHOYP_LOC590969.1.1 m.15822 sp COG1_MOUSE 37.826 920 532 18 19 912 17 922 0 617 COG1_MOUSE reviewed Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) (Low density lipoprotein receptor defect B-complementing protein) Cog1 Ldlb Mus musculus (Mouse) 980 "Golgi organization [GO:0007030]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" GO:0000139; GO:0000301; GO:0005794; GO:0007030; GO:0015031; GO:0017119 0 0 0 0 Q9Z1G4 CHOYP_LOC100741247.1.2 m.232 sp VPP1_MOUSE 64.209 841 260 5 1 802 1 839 0 1099 VPP1_MOUSE reviewed V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) Atp6v0a1 Atp6n1 Mus musculus (Mouse) 839 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986]; regulation of macroautophagy [GO:0016241]; toxin transport [GO:1901998]; vacuolar acidification [GO:0007035]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] GO:0000220; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0007035; GO:0015986; GO:0015991; GO:0016021; GO:0016241; GO:0016471; GO:0030659; GO:0042470; GO:0043231; GO:0046961; GO:0051117; GO:0070062; GO:0070072; GO:1901998 0 0 0 PF01496; Q9Z1G4 CHOYP_LOC100741247.2.2 m.27816 sp VPP1_MOUSE 64.153 809 279 7 252 1054 31 834 0 1060 VPP1_MOUSE reviewed V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) Atp6v0a1 Atp6n1 Mus musculus (Mouse) 839 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986]; regulation of macroautophagy [GO:0016241]; toxin transport [GO:1901998]; vacuolar acidification [GO:0007035]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] GO:0000220; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0007035; GO:0015986; GO:0015991; GO:0016021; GO:0016241; GO:0016471; GO:0030659; GO:0042470; GO:0043231; GO:0046961; GO:0051117; GO:0070062; GO:0070072; GO:1901998 0 0 0 PF01496; Q9Z1G4 CHOYP_VPP1.1.2 m.2769 sp VPP1_MOUSE 54.674 920 318 11 1 902 1 839 0 990 VPP1_MOUSE reviewed V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) Atp6v0a1 Atp6n1 Mus musculus (Mouse) 839 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986]; regulation of macroautophagy [GO:0016241]; toxin transport [GO:1901998]; vacuolar acidification [GO:0007035]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072] GO:0000220; GO:0005654; GO:0005737; GO:0005794; GO:0005886; GO:0007035; GO:0015986; GO:0015991; GO:0016021; GO:0016241; GO:0016471; GO:0030659; GO:0042470; GO:0043231; GO:0046961; GO:0051117; GO:0070062; GO:0070072; GO:1901998 0 0 0 PF01496; Q9Z1J3 CHOYP_NFS1.1.1 m.1622 sp NFS1_MOUSE 80.549 401 78 0 67 467 59 459 0 707 NFS1_MOUSE reviewed "Cysteine desulfurase, mitochondrial (m-Nfs1) (EC 2.8.1.7)" Nfs1 Nifs Mus musculus (Mouse) 459 [2Fe-2S] cluster assembly [GO:0044571]; iron incorporation into metallo-sulfur cluster [GO:0018283]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006777; GO:0018283; GO:0030170; GO:0031071; GO:0042803; GO:0043231; GO:0044571; GO:0046872; GO:0051536 0 0 0 PF00266; Q9Z1N3 CHOYP_LOC100870108.1.4 m.31812 sp MYO9A_RAT 47.029 1178 492 21 22 1082 6 1168 0 1032 MYO9A_RAT reviewed Unconventional myosin-IXa (Myr 7) (Unconventional myosin-9a) Myo9a Myr7 Rattus norvegicus (Rat) 2626 intracellular signal transduction [GO:0035556] GO:0003774; GO:0005096; GO:0005524; GO:0005737; GO:0016021; GO:0016459; GO:0035556; GO:0046872 0 0 0 PF00612;PF00063;PF00788;PF00620; Q9Z1N3 CHOYP_LOC100870108.2.4 m.33311 sp MYO9A_RAT 47.029 1178 492 21 22 1082 6 1168 0 1031 MYO9A_RAT reviewed Unconventional myosin-IXa (Myr 7) (Unconventional myosin-9a) Myo9a Myr7 Rattus norvegicus (Rat) 2626 intracellular signal transduction [GO:0035556] GO:0003774; GO:0005096; GO:0005524; GO:0005737; GO:0016021; GO:0016459; GO:0035556; GO:0046872 0 0 0 PF00612;PF00063;PF00788;PF00620; Q9Z1N3 CHOYP_LOC100870108.4.4 m.56826 sp MYO9A_RAT 46.999 1183 485 21 22 1082 6 1168 0 1031 MYO9A_RAT reviewed Unconventional myosin-IXa (Myr 7) (Unconventional myosin-9a) Myo9a Myr7 Rattus norvegicus (Rat) 2626 intracellular signal transduction [GO:0035556] GO:0003774; GO:0005096; GO:0005524; GO:0005737; GO:0016021; GO:0016459; GO:0035556; GO:0046872 0 0 0 PF00612;PF00063;PF00788;PF00620; Q9Z1N9 CHOYP_LOC100650524.1.2 m.34661 sp UN13B_MOUSE 68.596 1261 350 17 531 1787 384 1602 0 1773 UN13B_MOUSE reviewed Protein unc-13 homolog B (Munc13-2) (munc13) Unc13b Unc13a Mus musculus (Mouse) 1602 "chemical synaptic transmission [GO:0007268]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; neuromuscular junction development [GO:0007528]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic vesicle priming [GO:0010808]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" GO:0001566; GO:0005794; GO:0005829; GO:0005886; GO:0007268; GO:0007528; GO:0010808; GO:0016081; GO:0016082; GO:0019992; GO:0030054; GO:0031594; GO:0035249; GO:0035556; GO:0043195; GO:0046872; GO:0048172; GO:0060384; GO:0097151 0 0 0 PF00130;PF00168;PF06292;PF10540; Q9Z1N9 CHOYP_LOC100650524.2.2 m.53643 sp UN13B_MOUSE 68.941 1246 345 16 531 1761 384 1602 0 1771 UN13B_MOUSE reviewed Protein unc-13 homolog B (Munc13-2) (munc13) Unc13b Unc13a Mus musculus (Mouse) 1602 "chemical synaptic transmission [GO:0007268]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; neuromuscular junction development [GO:0007528]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic vesicle priming [GO:0010808]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" GO:0001566; GO:0005794; GO:0005829; GO:0005886; GO:0007268; GO:0007528; GO:0010808; GO:0016081; GO:0016082; GO:0019992; GO:0030054; GO:0031594; GO:0035249; GO:0035556; GO:0043195; GO:0046872; GO:0048172; GO:0060384; GO:0097151 0 0 0 PF00130;PF00168;PF06292;PF10540; Q9Z1T6 CHOYP_FYV1.1.1 m.41923 sp FYV1_MOUSE 33.552 1523 759 37 104 1500 129 1524 0 778 FYV1_MOUSE reviewed 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (p235) Pikfyve Kiaa0981 Pip5k3 Mus musculus (Mouse) 2097 "intracellular signal transduction [GO:0035556]; myelin assembly [GO:0032288]; protein localization to nucleus [GO:0034504]; regulation of autophagosome assembly [GO:2000785]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000139; GO:0000285; GO:0005524; GO:0005829; GO:0005911; GO:0008270; GO:0010008; GO:0012506; GO:0016308; GO:0030659; GO:0031410; GO:0031901; GO:0031902; GO:0032288; GO:0034504; GO:0035556; GO:0042147; GO:0045121; GO:0048471; GO:0052810; GO:2000785 0 0 0 PF00118;PF00610;PF01363;PF01504; Q9Z1W9 CHOYP_ISCW_ISCW022925.2.2 m.61538 sp STK39_MOUSE 60.345 522 171 5 23 541 68 556 0 630 STK39_MOUSE reviewed STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (Serine/threonine-protein kinase 39) Stk39 Spak Mus musculus (Mouse) 556 cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; negative regulation of rubidium ion transport [GO:2000681]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of potassium ion transport [GO:0043268]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of ion homeostasis [GO:2000021]; signal transduction by protein phosphorylation [GO:0023014] GO:0001933; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0005856; GO:0008217; GO:0016020; GO:0016323; GO:0016324; GO:0018105; GO:0018107; GO:0023014; GO:0035556; GO:0043268; GO:0050727; GO:0071476; GO:0090188; GO:1901017; GO:1901380; GO:2000021; GO:2000681; GO:2000687 0 0 0 PF12202;PF00069; Q9Z1W9 CHOYP_PAXB1.1.2 m.42816 sp STK39_MOUSE 60.345 522 171 5 859 1377 68 556 0 629 STK39_MOUSE reviewed STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (Serine/threonine-protein kinase 39) Stk39 Spak Mus musculus (Mouse) 556 cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; negative regulation of rubidium ion transport [GO:2000681]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of potassium ion transport [GO:0043268]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of ion homeostasis [GO:2000021]; signal transduction by protein phosphorylation [GO:0023014] GO:0001933; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0005856; GO:0008217; GO:0016020; GO:0016323; GO:0016324; GO:0018105; GO:0018107; GO:0023014; GO:0035556; GO:0043268; GO:0050727; GO:0071476; GO:0090188; GO:1901017; GO:1901380; GO:2000021; GO:2000681; GO:2000687 0 0 0 PF12202;PF00069; Q9Z1Z0 CHOYP_USO1.1.11 m.6354 sp USO1_MOUSE 52.836 952 405 11 14 939 1 934 0 934 USO1_MOUSE reviewed General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) Uso1 Vdp Mus musculus (Mouse) 959 ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; transcytosis [GO:0045056]; vesicle fusion with Golgi apparatus [GO:0048280] GO:0000139; GO:0005730; GO:0005783; GO:0005794; GO:0005795; GO:0005829; GO:0006886; GO:0006888; GO:0007030; GO:0008565; GO:0012507; GO:0016020; GO:0044822; GO:0045056; GO:0048211; GO:0048280; GO:0048471; GO:0061025 0 0 0 PF04871;PF04869; Q9Z207 CHOYP_DIAP2.1.1 m.25706 sp DIAP3_MOUSE 42.857 1001 538 13 60 1045 88 1069 0 754 DIAP3_MOUSE reviewed Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (p134mDIA2) (mDIA2) Diaph3 Diap3 Mus musculus (Mouse) 1171 actin cytoskeleton organization [GO:0030036]; spermatogenesis [GO:0007283] GO:0005634; GO:0005829; GO:0007283; GO:0030036 0 0 0 PF06345;PF06367;PF06371;PF02181; Q9Z2A7 CHOYP_DGAT1.1.2 m.6148 sp DGAT1_MOUSE 57.87 432 167 3 52 482 74 491 0 531 DGAT1_MOUSE reviewed Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) Dgat1 Dgat Mus musculus (Mouse) 498 diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; triglyceride biosynthetic process [GO:0019432]; very-low-density lipoprotein particle assembly [GO:0034379] GO:0003846; GO:0004144; GO:0005789; GO:0016020; GO:0016021; GO:0019432; GO:0019915; GO:0034379; GO:0035336; GO:0043231; GO:0046339; GO:0050252; GO:0055089 PATHWAY: Lipid metabolism; glycerolipid metabolism. 0 0 PF03062; Q9Z2A7 CHOYP_DGAT1.2.2 m.17453 sp DGAT1_MOUSE 58.178 428 164 3 159 585 78 491 0 531 DGAT1_MOUSE reviewed Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase) Dgat1 Dgat Mus musculus (Mouse) 498 diacylglycerol metabolic process [GO:0046339]; fatty acid homeostasis [GO:0055089]; lipid storage [GO:0019915]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; triglyceride biosynthetic process [GO:0019432]; very-low-density lipoprotein particle assembly [GO:0034379] GO:0003846; GO:0004144; GO:0005789; GO:0016020; GO:0016021; GO:0019432; GO:0019915; GO:0034379; GO:0035336; GO:0043231; GO:0046339; GO:0050252; GO:0055089 PATHWAY: Lipid metabolism; glycerolipid metabolism. 0 0 PF03062; Q9Z2D0 CHOYP_MTMR9.1.1 m.26430 sp MTMR9_MOUSE 59.266 545 219 2 1 545 1 542 0 692 MTMR9_MOUSE reviewed Myotubularin-related protein 9 Mtmr9 Mtmr3 Mus musculus (Mouse) 545 0 GO:0005737; GO:0030234 0 0 0 PF06602; Q9Z2J0 CHOYP_BRAFLDRAFT_90196.1.2 m.7028 sp S23A1_MOUSE 51.494 569 260 7 52 617 37 592 0 596 S23A1_MOUSE reviewed Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3) Slc23a1 Svct1 Yspl3 Mus musculus (Mouse) 605 brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid transport [GO:0015882]; lung development [GO:0030324]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]; transepithelial L-ascorbic acid transport [GO:0070904] GO:0005737; GO:0005886; GO:0006814; GO:0007420; GO:0008520; GO:0009636; GO:0009925; GO:0015081; GO:0015229; GO:0015882; GO:0016021; GO:0016324; GO:0030324; GO:0033300; GO:0043229; GO:0070062; GO:0070837; GO:0070890; GO:0070904 0 0 0 PF00860; Q9Z2K9 CHOYP_IDHC.1.1 m.7041 sp IDHC_MICME 80.988 405 77 0 3 407 4 408 0 704 IDHC_MICME reviewed Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) IDH1 IDP2 Microtus mexicanus (Mexican vole) 414 2-oxoglutarate metabolic process [GO:0006103]; glyoxylate cycle [GO:0006097]; isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] GO:0000287; GO:0004450; GO:0005737; GO:0006097; GO:0006099; GO:0006102; GO:0006103; GO:0051287 0 0 0 PF00180; U3JAG9 CHOYP_LOC100374850.2.2 m.25393 sp CP131_DANRE 41.817 1222 544 34 1 1174 11 1113 0 730 CP131_DANRE reviewed Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) cep131 azi1 Danio rerio (Zebrafish) (Brachydanio rerio) 1113 cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; negative regulation of intracellular protein transport [GO:0090317]; regulation of centrosome duplication [GO:0010824]; sensory perception of light stimulus [GO:0050953] GO:0000775; GO:0005929; GO:0010824; GO:0030154; GO:0032402; GO:0034451; GO:0035721; GO:0035735; GO:0050953; GO:0060271; GO:0060287; GO:0070121; GO:0090317 0 0 0 0 A8T6P4 CHOYP_UNC89.1.19 m.7848 sp MYRIP_DANRE 45.033 151 79 1 13 159 1 151 1.00E-38 160 MYRIP_DANRE reviewed Rab effector MyRIP (Exophilin-8) (Myosin VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c) myrip akap2 si:dkey-12l12.1 si:dkey-189e1.3 Danio rerio (Zebrafish) (Brachydanio rerio) 838 intracellular protein transport [GO:0006886] GO:0006886; GO:0030133; GO:0046872; GO:0048471 0 0 0 PF02318;PF04698; B7U179 CHOYP_CRE_06886.1.1 m.35204 sp ABAP1_ARATH 30.357 112 73 2 32 143 559 665 1.00E-07 57 ABAP1_ARATH reviewed ARMADILLO BTB ARABIDOPSIS PROTEIN 1 (ABAP1) ABAP1 At5g13060 T19L5.20 Arabidopsis thaliana (Mouse-ear cress) 737 DNA-dependent DNA replication [GO:0006261]; negative regulation of cell proliferation [GO:0008285]; negative regulation of DNA-dependent DNA replication [GO:2000104]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127] GO:0005634; GO:0005737; GO:0006261; GO:0008285; GO:0016567; GO:0031261; GO:0042127; GO:2000104 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00514;PF00651; G5E8K5 CHOYP_AASI_1435.8.35 m.32848 sp ANK3_MOUSE 33.429 697 432 4 137 832 20 685 1.00E-98 341 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; G5EFC3 CHOYP_KCNC4.4.5 m.51873 sp KCNAG_CAEEL 37.778 450 250 9 26 456 26 464 1.00E-91 301 KCNAG_CAEEL reviewed Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36) egl-36 R07A4.1 Caenorhabditis elegans 558 ion transmembrane transport [GO:0034220]; protein homooligomerization [GO:0051260] GO:0005244; GO:0005251; GO:0008076; GO:0016021; GO:0034220; GO:0051260 0 0 0 PF02214;PF00520; O19048 CHOYP_NEMVEDRAFT_V1G214512.1.1 m.66039 sp PCBP1_RABIT 47.541 61 30 1 46 106 277 335 1.00E-07 51.6 PCBP1_RABIT reviewed Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) PCBP1 Oryctolagus cuniculus (Rabbit) 356 0 GO:0003697; GO:0003729; GO:0005654; GO:0005737; GO:0016020; GO:0030529; GO:0070062 0 0 0 PF00013; O75626 CHOYP_BLIMP-1.1.1 m.55502 sp PRDM1_HUMAN 68.108 185 52 3 512 693 541 721 1.00E-76 268 PRDM1_HUMAN reviewed PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1) PRDM1 BLIMP1 Homo sapiens (Human) 825 "aorta development [GO:0035904]; artery morphogenesis [GO:0048844]; cell fate commitment [GO:0045165]; coronary vasculature development [GO:0060976]; eye photoreceptor cell development [GO:0042462]; germ cell development [GO:0007281]; heart valve development [GO:0003170]; intestinal epithelial cell development [GO:0060576]; maternal placenta development [GO:0001893]; morphogenesis of a branching structure [GO:0001763]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of gene expression [GO:0010628]; post-embryonic development [GO:0009791]; regulation of extrathymic T cell differentiation [GO:0033082]; regulation of natural killer cell differentiation [GO:0032823]; regulation of NK T cell differentiation [GO:0051136]; sebum secreting cell proliferation [GO:1990654]; transcription, DNA-templated [GO:0006351]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281]" GO:0000122; GO:0000978; GO:0001078; GO:0001763; GO:0001893; GO:0003170; GO:0003281; GO:0003700; GO:0005654; GO:0005737; GO:0006351; GO:0007281; GO:0008168; GO:0009791; GO:0010628; GO:0030889; GO:0031665; GO:0032823; GO:0033082; GO:0035904; GO:0042462; GO:0045165; GO:0045579; GO:0046872; GO:0048844; GO:0051136; GO:0060576; GO:0060707; GO:0060976; GO:1990654; GO:1990841 0 0 0 PF00856;PF13912; O88281 CHOYP_CRE_01394.2.2 m.50149 sp MEGF6_RAT 36.449 321 146 14 188 464 866 1172 1.00E-38 153 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O97504 CHOYP_LOC100693573.1.1 m.10016 sp MC4R_PIG 23.667 300 178 8 65 352 50 310 1.00E-12 72.4 MC4R_PIG reviewed Melanocortin receptor 4 (MC4-R) MC4R Sus scrofa (Pig) 332 0 GO:0004977; GO:0005886; GO:0016021 0 0 0 PF00001; P08181 CHOYP_BRAFLDRAFT_113587.1.1 m.12524 sp CSK2A_DROME 70.667 225 66 0 48 272 3 227 1.00E-106 315 CSK2A_DROME reviewed Casein kinase II subunit alpha (CK II subunit alpha) (EC 2.7.11.1) CkIIalpha Cask-II-a CG17520 Drosophila melanogaster (Fruit fly) 336 axon guidance [GO:0007411]; cellular response to starvation [GO:0009267]; chaeta development [GO:0022416]; circadian rhythm [GO:0007623]; compound eye development [GO:0048749]; intracellular mRNA localization involved in pattern specification process [GO:0060810]; lateral inhibition [GO:0046331]; locomotor rhythm [GO:0045475]; mitotic nuclear division [GO:0007067]; negative regulation of protein ubiquitination [GO:0031397]; oocyte dorsal/ventral axis specification [GO:0007310]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of Wnt signaling pathway [GO:0030177]; protein phosphorylation [GO:0006468]; regulation of protein stability [GO:0031647]; Wnt signaling pathway [GO:0016055] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005956; GO:0006468; GO:0007067; GO:0007228; GO:0007310; GO:0007411; GO:0007623; GO:0009267; GO:0016055; GO:0022416; GO:0030177; GO:0031397; GO:0031647; GO:0045475; GO:0045880; GO:0046331; GO:0048749; GO:0060810 0 0 0 PF00069; P09645 CHOYP_LOC100366892.1.3 m.17710 sp TBA8_CHICK 93.913 115 7 0 1 115 29 143 1.00E-71 221 TBA8_CHICK reviewed Tubulin alpha-8 chain (Fragment) 0 Gallus gallus (Chicken) 324 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P0C1Q3 CHOYP_PCAT2.1.2 m.6886 sp PCAT2_RAT 54.808 104 46 1 1 104 113 215 1.00E-29 113 PCAT2_RAT reviewed Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) Lpcat2 Aytl1 Aytl1a Lpcat2a Rattus norvegicus (Rat) 544 membrane organization [GO:0061024]; platelet activating factor biosynthetic process [GO:0006663] GO:0000139; GO:0003841; GO:0005509; GO:0005783; GO:0005789; GO:0005795; GO:0005811; GO:0006663; GO:0016021; GO:0047184; GO:0047192; GO:0061024 PATHWAY: Lipid metabolism; phospholipid metabolism. 0 0 PF01553;PF13499; P10079 CHOYP_LOC100634060.4.37 m.4129 sp FBP1_STRPU 54.688 320 145 0 1 320 204 523 1.00E-107 340 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P15145 CHOYP_AMPN.1.1 m.28244 sp AMPN_PIG 39.506 162 95 1 185 343 71 232 1.00E-28 120 AMPN_PIG reviewed Aminopeptidase N (AP-N) (pAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (gp130) (CD antigen CD13) ANPEP Sus scrofa (Pig) 963 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P16157 CHOYP_AFUA_1G01020.3.50 m.913 sp ANK1_HUMAN 39.035 228 139 0 3 230 349 576 1.00E-41 154 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18503 CHOYP_BRAFLDRAFT_74515.1.1 m.60449 sp CAS4_EPHMU 33.884 121 66 3 94 214 207 313 1.00E-07 55.8 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P25931 CHOYP_GPRNPY3.1.1 m.43637 sp NPYR_DROME 32 375 224 7 29 377 95 464 1.00E-58 201 NPYR_DROME reviewed Neuropeptide Y receptor (NPY-R) (PR4 receptor) (RYamide receptor) RYa-R NepYr CG5811 Drosophila melanogaster (Fruit fly) 464 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0001653; GO:0004983; GO:0005886; GO:0007166; GO:0007186; GO:0008188; GO:0016021 0 0 0 PF00001; P28656 CHOYP_RL18.2.2 m.38043 sp NP1L1_MOUSE 72.609 230 58 4 203 430 165 391 1.00E-92 288 NP1L1_MOUSE reviewed Nucleosome assembly protein 1-like 1 (Brain protein DN38) (NAP-1-related protein) Nap1l1 Nrp Mus musculus (Mouse) 391 nucleosome assembly [GO:0006334] GO:0005634; GO:0006334; GO:0016020; GO:0042470; GO:0044822 0 0 0 PF00956; P34268 CHOYP_LOC100783057.1.1 m.35218 sp FLII_CAEEL 27.402 281 172 11 6 279 118 373 1.00E-06 55.1 FLII_CAEEL reviewed Protein flightless-1 homolog fli-1 B0523.5 Caenorhabditis elegans 1257 actin cytoskeleton organization [GO:0030036]; actin filament severing [GO:0051014]; multicellular organism development [GO:0007275] GO:0005634; GO:0007275; GO:0030036; GO:0051014 0 0 0 PF00626;PF13855; P42674 CHOYP_BP10.1.3 m.5379 sp BP10_PARLI 33.425 362 216 11 118 468 89 436 1.00E-49 184 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P42674 CHOYP_BRAFLDRAFT_92410.1.1 m.36946 sp BP10_PARLI 33.333 432 249 15 140 559 45 449 1.00E-54 201 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P47809 CHOYP_MAP2K4.1.1 m.15514 sp MP2K4_MOUSE 59.712 139 45 4 54 181 34 172 1.00E-46 160 MP2K4_MOUSE reviewed Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) Map2k4 Jnkk1 Mek4 Mkk4 Prkmk4 Sek1 Serk1 Skk1 Mus musculus (Mouse) 397 activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; response to wounding [GO:0009611] GO:0000165; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007254; GO:0007257; GO:0009611; GO:0034393; GO:0071260; GO:2000672 0 0 0 PF00069; P56405 CHOYP_BRAFLDRAFT_200162.3.4 m.58879 sp AQP8_RAT 35.685 241 138 6 17 251 31 260 1.00E-43 151 AQP8_RAT reviewed Aquaporin-8 (AQP-8) Aqp8 Rattus norvegicus (Rat) 263 canalicular bile acid transport [GO:0015722]; cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; water transport [GO:0006833] GO:0005886; GO:0005887; GO:0006833; GO:0009992; GO:0015250; GO:0015254; GO:0015722; GO:0034220; GO:0043231; GO:0046691 0 0 0 PF00230; P56719 CHOYP_TRFR.1.3 m.40455 sp OX2R_RAT 25.749 334 214 11 31 341 67 389 1.00E-13 75.1 OX2R_RAT reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0004930; GO:0005887; GO:0007186; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P79781 CHOYP_UBIQP.13.13 m.63875 sp RS27A_CHICK 94.215 121 7 0 15 135 36 156 1.00E-69 209 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; P86854 CHOYP_COLEC12.2.2 m.3986 sp PLCL_MYTGA 34.351 131 82 4 20 148 28 156 1.00E-21 88.6 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q12982 CHOYP_LOC100022124.1.1 m.40852 sp BNIP2_HUMAN 28.662 157 88 5 14 151 3 154 1.00E-10 61.6 BNIP2_HUMAN reviewed BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 BNIP2 NIP2 Homo sapiens (Human) 314 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of muscle cell differentiation [GO:0051149] GO:0005096; GO:0005509; GO:0005635; GO:0005737; GO:0005829; GO:0006915; GO:0042802; GO:0043066; GO:0043231; GO:0048471; GO:0051149 0 0 0 PF12496;PF13716; Q17R14 CHOYP_ISCW_ISCW018858.1.1 m.63225 sp MYO1D_BOVIN 59.585 386 153 2 6 391 4 386 1.00E-157 472 MYO1D_BOVIN reviewed Unconventional myosin-Id MYO1D Bos taurus (Bovine) 1006 cellular localization [GO:0051641]; early endosome to recycling endosome transport [GO:0061502]; negative regulation of phosphatase activity [GO:0010923] GO:0003774; GO:0005516; GO:0005524; GO:0005768; GO:0005829; GO:0005903; GO:0010923; GO:0016323; GO:0016459; GO:0030424; GO:0030898; GO:0031410; GO:0043005; GO:0043025; GO:0043209; GO:0051015; GO:0051641; GO:0061502; GO:0097440 0 0 0 PF00612;PF00063;PF06017; Q28824 CHOYP_PHUM_PHUM226120.5.7 m.43553 sp MYLK_BOVIN 45.403 533 256 6 59 579 531 1040 1.00E-153 474 MYLK_BOVIN reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK Bos taurus (Bovine) 1176 positive regulation of cell migration [GO:0030335]; smooth muscle contraction [GO:0006939] GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0006939; GO:0030027; GO:0030335; GO:0032154; GO:0046872 0 0 0 PF00041;PF07679;PF00069; Q2TA16 CHOYP_LOC100369421.1.2 m.17340 sp CCD65_BOVIN 48.8 500 249 3 30 526 3 498 1.00E-157 461 CCD65_BOVIN reviewed Coiled-coil domain-containing protein 65 CCDC65 Bos taurus (Bovine) 498 0 0 0 0 0 0 Q3U481 CHOYP_PHT4.1.1 m.18842 sp MFS12_MOUSE 45.313 256 131 3 4 257 203 451 1.00E-66 219 MFS12_MOUSE reviewed Major facilitator superfamily domain-containing protein 12 Mfsd12 Mus musculus (Mouse) 476 transport [GO:0006810] GO:0005765; GO:0006810; GO:0016021 0 0 cd06174; 0 Q53G44 CHOYP_LOC101165968.7.7 m.56428 sp IF44L_HUMAN 33.181 437 263 9 23 455 24 435 1.00E-56 197 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5BKW7 CHOYP_ENPP6.2.5 m.5516 sp ENPP6_DANRE 33.2 250 159 3 4 247 175 422 1.00E-49 172 ENPP6_DANRE reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine cholinephosphodiesterase) (GPC-Cpde) enpp6 zgc:103605 Danio rerio (Zebrafish) (Brachydanio rerio) 438 choline metabolic process [GO:0019695]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629] GO:0005886; GO:0006629; GO:0008081; GO:0016042; GO:0019695; GO:0031225; GO:0047390 0 0 0 PF01663; Q5RJ80 CHOYP_LOC101066767.2.2 m.41081 sp CAPR2_DANRE 32.031 128 84 3 312 437 785 911 1.00E-10 67.8 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5S007 CHOYP_BRAFLDRAFT_119973.1.3 m.2813 sp LRRK2_HUMAN 45.321 545 277 11 3 539 1281 1812 1.00E-138 447 LRRK2_HUMAN reviewed Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) 2527 "activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular protein localization [GO:0034613]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron death [GO:0070997]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; protein autophosphorylation [GO:0046777]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of calcium-mediated signaling [GO:0050848]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron death [GO:1901214]; regulation of neuron maturation [GO:0014041]; regulation of protein kinase A signaling [GO:0010738]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; small GTPase mediated signal transduction [GO:0007264]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]" GO:0000149; GO:0000165; GO:0000186; GO:0000187; GO:0001933; GO:0001934; GO:0001948; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004708; GO:0005096; GO:0005524; GO:0005525; GO:0005615; GO:0005622; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005901; GO:0005902; GO:0006468; GO:0006897; GO:0006914; GO:0006979; GO:0007005; GO:0007030; GO:0007040; GO:0007264; GO:0007528; GO:0008017; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010738; GO:0010955; GO:0014041; GO:0015631; GO:0016234; GO:0016242; GO:0016301; GO:0016310; GO:0017048; GO:0017075; GO:0018105; GO:0018107; GO:0019722; GO:0021772; GO:0022028; GO:0030054; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030529; GO:0030672; GO:0031398; GO:0031410; GO:0031966; GO:0032091; GO:0032092; GO:0032436; GO:0032473; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034613; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0035751; GO:0036479; GO:0039706; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0043406; GO:0044325; GO:0044753; GO:0044754; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0050848; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060070; GO:0060079; GO:0060159; GO:0060161; GO:0060828; GO:0061001; GO:0070062; GO:0070585; GO:0070997; GO:0071287; GO:0072593; GO:0090140; GO:0090263; GO:0090394; GO:0097487; GO:0098794; GO:1901214; GO:1901215; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902823; GO:1902902; GO:1903125; GO:1903206; GO:1903215; GO:1903217; GO:1903351; GO:1904713; GO:1904887; GO:1905279; GO:1990909; GO:2000172; GO:2000300 0 0 0 PF16095;PF12799;PF13855;PF00069;PF08477; Q5ZJC8 CHOYP_MTER1.1.1 m.13084 sp MTEF3_CHICK 32.628 331 208 6 128 451 82 404 1.00E-48 174 MTEF3_CHICK reviewed "Transcription termination factor 3, mitochondrial (mTERF domain-containing protein 1, mitochondrial)" MTERF3 MTERFD1 CGI-12 RCJMB04_19e6 Gallus gallus (Chicken) 405 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003690; GO:0005739; GO:0006351; GO:0044212; GO:0045892 0 0 0 PF02536; Q60997 CHOYP_BRAFLDRAFT_120139.4.5 m.50713 sp DMBT1_MOUSE 27.713 516 323 14 30 529 1515 1996 1.00E-36 152 DMBT1_MOUSE reviewed Deleted in malignant brain tumors 1 protein (Apactin) (CRP-ductin) (Glycoprotein 300) (gp300) (Hensin) (Mucin-like glycoprotein) (Muclin) (Vomeroglandin) (p80) Dmbt1 Crpd Mus musculus (Mouse) 2085 blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; inner cell mass cell proliferation [GO:0001833]; positive regulation of epithelial cell differentiation [GO:0030858]; protein transport [GO:0015031] GO:0001824; GO:0001833; GO:0005044; GO:0005578; GO:0005615; GO:0005622; GO:0005737; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0030670; GO:0030858; GO:0035375; GO:0042589; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q62685 CHOYP_LOC100313647.1.1 m.1001 sp NR1H3_RAT 31.436 369 218 11 112 462 93 444 1.00E-46 171 NR1H3_RAT reviewed Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) (RLD-1) Nr1h3 Lxra Rattus norvegicus (Rat) 445 "insulin receptor signaling pathway [GO:0008286]; lipid metabolic process [GO:0006629]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cholesterol homeostasis [GO:2000188]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0005737; GO:0006351; GO:0006629; GO:0008270; GO:0008286; GO:0043565; GO:0045893; GO:0046965; GO:0046982; GO:2000188 0 0 0 PF00104;PF00105; Q6GNT9 CHOYP_BRAFLDRAFT_114006.1.1 m.49056 sp MEMO1_XENLA 65.085 295 101 1 52 346 5 297 1.00E-146 418 MEMO1_XENLA reviewed Protein MEMO1 (Mediator of ErbB2-driven cell motility 1) (Memo-1) memo1 Xenopus laevis (African clawed frog) 297 0 0 0 0 cd07361; PF01875; Q6INX4 CHOYP_LOC101157819.1.1 m.20192 sp ENOF1_XENLA 58.741 143 59 0 10 152 65 207 1.00E-59 194 ENOF1_XENLA reviewed Mitochondrial enolase superfamily member 1 (L-fuconate dehydratase) (EC 4.2.1.68) enosf1 Xenopus laevis (African clawed frog) 445 cellular carbohydrate catabolic process [GO:0044275] GO:0000287; GO:0005739; GO:0016853; GO:0044275; GO:0050023 0 0 0 PF13378;PF02746; Q6MG82 CHOYP_RTO_05940.3.3 m.66655 sp PRRT1_RAT 40.845 71 42 0 45 115 220 290 1.00E-11 63.2 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6PFY8 CHOYP_TRI46.2.3 m.61659 sp TRI45_MOUSE 29.208 202 123 5 7 196 129 322 1.00E-11 68.9 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q70FG7 CHOYP_LIGB.1.1 m.36149 sp DODA_BETVU 36.653 251 148 5 25 269 14 259 1.00E-45 157 DODA_BETVU reviewed "4,5-DOPA dioxygenase extradiol (EC 1.13.11.29)" DODA Beta vulgaris (Sugar beet) 268 cellular aromatic compound metabolic process [GO:0006725]; oxidation-reduction process [GO:0055114] GO:0005737; GO:0006725; GO:0008198; GO:0008270; GO:0046566; GO:0050297; GO:0055114 PATHWAY: Pigment biosynthesis; betalain biosynthesis. 0 cd07363; PF02900; Q7TN29 CHOYP_LOC100120440.1.1 m.15371 sp SMAP2_MOUSE 40.529 454 208 20 9 429 4 428 1.00E-74 243 SMAP2_MOUSE reviewed Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) Smap2 Smap1l Mus musculus (Mouse) 428 0 GO:0005096; GO:0005654; GO:0005737; GO:0046872 0 0 0 PF01412; Q803Q4 CHOYP_DEP1A.1.1 m.50111 sp DEP1A_DANRE 43.455 191 101 3 55 240 585 773 1.00E-36 142 DEP1A_DANRE reviewed DEP domain-containing protein 1A depdc1a Danio rerio (Zebrafish) (Brachydanio rerio) 800 intracellular signal transduction [GO:0035556] GO:0005096; GO:0005622; GO:0035556 0 0 0 PF00610; Q80V70 CHOYP_MEGF6.31.59 m.41133 sp MEGF6_MOUSE 27.056 462 272 15 1 429 862 1291 1.00E-23 107 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8BRK9 CHOYP_TRIADDRAFT_60265.1.1 m.52546 sp MA2A2_MOUSE 49.573 351 164 4 101 440 161 509 1.00E-121 384 MA2A2_MOUSE reviewed "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" Man2a2 Mana2x Mus musculus (Mouse) 1152 mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein deglycosylation [GO:0006517] GO:0000139; GO:0004559; GO:0004572; GO:0006013; GO:0006491; GO:0006517; GO:0008270; GO:0015923; GO:0016021; GO:0016799; GO:0030246 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09261;PF01074;PF07748; Q8BV79 CHOYP_LOC101317677.1.1 m.31587 sp TRNK1_MOUSE 24.079 353 223 12 3 324 2339 2677 1.00E-10 67.8 TRNK1_MOUSE reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1) Trank1 Gm187 Kiaa0342 Lba1 Mus musculus (Mouse) 2999 0 0 0 0 0 0 Q8CG72 CHOYP_BRAFLDRAFT_241420.1.1 m.61408 sp ARHL2_MOUSE 40.379 369 190 8 19 386 26 365 1.00E-81 257 ARHL2_MOUSE reviewed Poly(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) (ADP-ribosylhydrolase 3) ([Protein ADP-ribosylarginine] hydrolase-like protein 2) Adprhl2 Arh3 Mus musculus (Mouse) 370 cellular response to superoxide [GO:0071451] GO:0004649; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005759; GO:0046872; GO:0071451 0 0 0 PF03747; Q8K2Y0 CHOYP_RNF219.1.1 m.51780 sp RN219_MOUSE 42.262 168 87 2 6 163 87 254 1.00E-28 127 RN219_MOUSE reviewed RING finger protein 219 Rnf219 Mus musculus (Mouse) 722 "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" GO:0008270; GO:0048026 0 0 0 0 Q8WXG9 CHOYP_LOC100891789.1.1 m.13947 sp GPR98_HUMAN 35.366 82 51 2 1 81 5694 5774 1.00E-09 57.4 GPR98_HUMAN reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 Homo sapiens (Human) 6306 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; maintenance of organ identity [GO:0048496]; nervous system development [GO:0007399]; neurological system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; single organismal cell-cell adhesion [GO:0016337]; visual perception [GO:0007601] GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0007166; GO:0007186; GO:0007399; GO:0007601; GO:0007605; GO:0009986; GO:0016020; GO:0016021; GO:0016337; GO:0032420; GO:0043235; GO:0045202; GO:0045494; GO:0048496; GO:0050877; GO:0050953; GO:0070062 0 0 0 PF00002;PF03160;PF03736; Q969G6 CHOYP_RS7.5.9 m.38700 sp RIFK_HUMAN 62.585 147 55 0 25 171 4 150 1.00E-66 204 RIFK_HUMAN reviewed Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase) RFK Homo sapiens (Human) 155 apoptotic process [GO:0006915]; FMN biosynthetic process [GO:0009398]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; reactive oxygen species metabolic process [GO:0072593]; riboflavin biosynthetic process [GO:0009231]; riboflavin metabolic process [GO:0006771] GO:0005524; GO:0005737; GO:0005739; GO:0005829; GO:0006771; GO:0006915; GO:0008531; GO:0009231; GO:0009398; GO:0033864; GO:0046872; GO:0072593 PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. 0 0 PF01687; Q99996 CHOYP_LOC582174.6.16 m.32837 sp AKAP9_HUMAN 51.02 49 24 0 73 121 3584 3632 1.00E-06 49.7 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9CQV5 CHOYP_LOC100371319.1.1 m.10777 sp RT24_MOUSE 39.506 162 84 5 3 162 9 158 1.00E-25 99.8 RT24_MOUSE reviewed "28S ribosomal protein S24, mitochondrial (MRP-S24) (S24mt)" Mrps24 Mus musculus (Mouse) 167 mitochondrial translation [GO:0032543]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005761; GO:0005763; GO:0006412; GO:0032543; GO:0044822 0 0 0 PF14955; Q9ERD9 CHOYP_PRP31.1.6 m.4167 sp I23O1_RAT 38.983 177 107 1 51 227 72 247 1.00E-34 130 I23O1_RAT reviewed "Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)" Ido1 Ido Indo Rattus norvegicus (Rat) 407 immune system process [GO:0002376]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0002376; GO:0005829; GO:0016597; GO:0019441; GO:0019825; GO:0020037; GO:0033754; GO:0046872 0 0 0 PF01231; Q9GKT2 CHOYP_LOC100373768.1.1 m.12125 sp FXDC2_MACFA 52.244 312 149 0 41 352 20 331 1.00E-118 349 FXDC2_MACFA reviewed Fatty acid hydroxylase domain-containing protein 2 FAXDC2 QccE-20373 QflA-14437 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 333 fatty acid biosynthetic process [GO:0006633] GO:0005506; GO:0006633; GO:0016021; GO:0016491 0 0 0 PF04116; Q9N1R6 CHOYP_BAT1.3.4 m.28932 sp BAT1_RABIT 34.974 386 248 2 2 385 99 483 1.00E-73 244 BAT1_RABIT reviewed "b(0,+)-type amino acid transporter 1 (b(0,+)AT) (4F2-LC6) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Oryctolagus cuniculus (Rabbit) 487 L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804] GO:0005886; GO:0015175; GO:0015184; GO:0015804; GO:0015811; GO:0016021; GO:0016324; GO:0031526; GO:0042605 0 0 0 PF13520; Q9NY25 CHOYP_LOC100893232.1.1 m.37321 sp CLC5A_HUMAN 33.333 96 57 3 153 248 63 151 1.00E-10 64.3 CLC5A_HUMAN reviewed C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) CLEC5A CLECSF5 MDL1 Homo sapiens (Human) 188 cellular defense response [GO:0006968]; innate immune response [GO:0045087]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myeloid cell apoptotic process [GO:0033033]; osteoblast development [GO:0002076]; positive regulation of cytokine secretion [GO:0050715]; signal transduction [GO:0007165] GO:0001618; GO:0002076; GO:0005886; GO:0005887; GO:0006968; GO:0007165; GO:0009986; GO:0030099; GO:0030246; GO:0033033; GO:0043066; GO:0045087; GO:0050715 0 0 0 PF00059; Q9P1Z9 CHOYP_LOC101236485.1.1 m.23597 sp CC180_HUMAN 34.4 125 77 2 462 581 11 135 1.00E-15 85.1 CC180_HUMAN reviewed Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) 1646 0 GO:0016021; GO:0070062 0 0 0 PF14643;PF14644; Q9UET6 CHOYP_LOC100370046.1.1 m.18329 sp TRM7_HUMAN 70.37 297 84 1 1 297 1 293 1.00E-149 427 TRM7_HUMAN reviewed Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (EC 2.1.1.205) (2'-O-ribose RNA methyltransferase TRM7 homolog) (Protein ftsJ homolog 1) FTSJ1 JM23 Homo sapiens (Human) 329 cytoplasmic translation [GO:0002181]; tRNA methylation [GO:0030488]; tRNA nucleoside ribose methylation [GO:0002128] GO:0002128; GO:0002181; GO:0005737; GO:0008175; GO:0030488 0 0 0 PF01728; A1L4H1 CHOYP_LOC100888203.1.1 m.54428 sp SRCRL_HUMAN 33.871 310 147 11 434 695 427 726 1.01E-25 117 SRCRL_HUMAN reviewed Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D) SSC5D Homo sapiens (Human) 1573 defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; negative regulation of interleukin-8 secretion [GO:2000483] GO:0001968; GO:0005044; GO:0005615; GO:0005622; GO:0005737; GO:0007275; GO:0016020; GO:0031012; GO:0042494; GO:0043236; GO:0045087; GO:0050829; GO:0050830; GO:0050840; GO:2000483 0 0 0 PF00530; A2AWP0 CHOYP_BIRC2.4.13 m.22269 sp BIRC7_MOUSE 52.727 55 25 1 175 229 223 276 1.01E-11 66.6 BIRC7_MOUSE reviewed Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Livin) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30 kDa subunit (Truncated livin) (p30-Livin) (tLivin)] Birc7 Livin Mus musculus (Mouse) 285 apoptotic process [GO:0006915]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127]; regulation of natural killer cell apoptotic process [GO:0070247]; regulation of signal transduction [GO:0009966] GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005794; GO:0005876; GO:0006915; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0042127; GO:0043066; GO:0070247; GO:0090307; GO:1990001 0 0 0 PF00653; A4IF63 CHOYP_BRAFLDRAFT_109858.5.6 m.53321 sp TRIM2_BOVIN 26.667 225 153 7 313 530 525 744 1.01E-12 74.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_63298.6.6 m.60187 sp TRIM2_BOVIN 29.545 132 90 2 63 191 611 742 1.01E-09 60.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7YY35 CHOYP_LOC100376186.2.7 m.20239 sp K2012_BOVIN 36.22 254 156 3 1169 1417 891 1143 1.01E-24 116 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; B1WB06 CHOYP_LOC100378720.1.1 m.26953 sp MET24_XENTR 25.989 177 115 7 282 447 114 285 1.01E-09 63.9 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; B5X8M4 CHOYP_LOC660560.2.4 m.40914 sp BRCC3_SALSA 64.8 250 85 2 1 250 1 247 1.01E-119 345 BRCC3_SALSA reviewed Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) brcc3 brcc36 Salmo salar (Atlantic salmon) 260 cell division [GO:0051301]; double-strand break repair [GO:0006302]; G2 DNA damage checkpoint [GO:0031572]; histone H2A K63-linked deubiquitination [GO:0070537]; mitotic nuclear division [GO:0007067]; positive regulation of DNA repair [GO:0045739]; protein K63-linked deubiquitination [GO:0070536]; response to ionizing radiation [GO:0010212] GO:0000922; GO:0004843; GO:0005634; GO:0005737; GO:0006302; GO:0007067; GO:0008237; GO:0010212; GO:0031572; GO:0031593; GO:0045739; GO:0046872; GO:0051301; GO:0070531; GO:0070536; GO:0070537; GO:0070552 0 0 0 PF01398; D3YXG0 CHOYP_HMCN1.14.44 m.33787 sp HMCN1_MOUSE 24.691 486 282 17 258 682 2488 2950 1.01E-19 98.6 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D3YXG0 CHOYP_NEMVEDRAFT_V1G86049.1.1 m.50842 sp HMCN1_MOUSE 48.571 315 162 0 44 358 4527 4841 1.01E-93 309 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O08585 CHOYP_BRAFLDRAFT_127100.1.2 m.2218 sp CLCA_MOUSE 45.662 219 82 5 17 209 28 235 1.01E-56 182 CLCA_MOUSE reviewed Clathrin light chain A (Lca) Clta Mus musculus (Mouse) 235 clathrin-mediated endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] GO:0005198; GO:0006886; GO:0016020; GO:0016023; GO:0030125; GO:0030130; GO:0030132; GO:0032050; GO:0043231; GO:0071439; GO:0072583 0 0 0 PF01086; O08618 CHOYP_KPRB.1.1 m.17501 sp KPRB_RAT 70.739 352 95 4 11 356 20 369 1.01E-169 480 KPRB_RAT reviewed Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41) Prpsap2 Rattus norvegicus (Rat) 369 bone development [GO:0060348]; nucleoside metabolic process [GO:0009116]; nucleotide biosynthetic process [GO:0009165] GO:0000287; GO:0002189; GO:0004749; GO:0009116; GO:0009165; GO:0043234; GO:0060348 0 0 cd06223; PF14572;PF13793; O14522 CHOYP_PTPRZ.5.9 m.24245 sp PTPRT_HUMAN 45.342 161 83 4 2 159 896 1054 1.01E-39 145 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O43396 CHOYP_LOC100114636.1.1 m.11052 sp TXNL1_HUMAN 55.052 287 125 3 5 288 4 289 1.01E-113 332 TXNL1_HUMAN reviewed Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein) TXNL1 TRP32 TXL TXNL Homo sapiens (Human) 289 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; protein folding [GO:0006457]; sulfate assimilation [GO:0000103] GO:0000103; GO:0000502; GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0006662; GO:0015035; GO:0015036; GO:0016671; GO:0034599; GO:0045454; GO:0070062 0 0 0 PF06201;PF00085; O57683 CHOYP_LOC100377153.1.1 m.44910 sp SF3B1_XENLA 46.429 112 48 5 32 141 4 105 1.01E-17 82.4 SF3B1_XENLA reviewed Splicing factor 3B subunit 1 (146 kDa nuclear protein) (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) sf3b1 Xenopus laevis (African clawed frog) 1307 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0008380 0 0 0 PF08920; O70528 CHOYP_5HT4R.1.1 m.42467 sp 5HT4R_CAVPO 34.891 321 181 9 33 331 7 321 1.01E-53 185 5HT4R_CAVPO reviewed 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) 388 chemical synaptic transmission [GO:0007268]; regulation of appetite [GO:0032098] GO:0004993; GO:0005768; GO:0005887; GO:0007268; GO:0032098 0 0 0 PF00001; O75581 CHOYP_BRAFLDRAFT_80379.1.1 m.41516 sp LRP6_HUMAN 23.923 418 298 9 20 428 100 506 1.01E-31 132 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; P00178 CHOYP_CP238.1.1 m.28005 sp CP2B4_RABIT 29.571 443 298 9 38 471 29 466 1.01E-56 199 CP2B4_RABIT reviewed Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1) CYP2B4 Oryctolagus cuniculus (Rabbit) 491 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P07572 CHOYP_LOC100494049.3.8 m.39387 sp POL_MPMV 30.233 215 117 10 77 276 69 265 1.01E-09 64.7 POL_MPMV reviewed Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) 867 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P09057 CHOYP_ODC1.1.1 m.12031 sp DCOR_RAT 56.658 383 161 3 37 416 37 417 1.01E-152 445 DCOR_RAT reviewed Ornithine decarboxylase (ODC) (EC 4.1.1.17) Odc1 Odc Rattus norvegicus (Rat) 461 kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell proliferation [GO:0008284]; putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615] GO:0001822; GO:0004586; GO:0005737; GO:0005829; GO:0006595; GO:0008284; GO:0009446; GO:0009615; GO:0033387; GO:0042176; GO:0042803; GO:0048471 PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. 0 0 PF02784;PF00278; P20594 CHOYP_ANPRA.1.1 m.41630 sp ANPRB_HUMAN 45.955 581 277 10 1 576 490 1038 1.01E-156 491 ANPRB_HUMAN reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 ANPRB Homo sapiens (Human) 1047 bone development [GO:0060348]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; single organism reproductive process [GO:0044702] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007168; GO:0008074; GO:0008217; GO:0016941; GO:0017046; GO:0035556; GO:0042562; GO:0044702; GO:0051447; GO:0060348; GO:0097011; GO:1900194; GO:1903779 0 0 0 PF01094;PF00211;PF07714; P23403 CHOYP_LOC100179448.1.1 m.8298 sp RS20_XENLA 92.308 117 7 2 4 118 3 119 1.01E-70 209 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P23403 CHOYP_LOC100550844.1.7 m.132 sp RS20_XENLA 92.308 117 7 2 4 118 3 119 1.01E-70 209 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P23403 CHOYP_LOC100550844.2.7 m.11995 sp RS20_XENLA 92.308 117 7 2 4 118 3 119 1.01E-70 209 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P23403 CHOYP_LOC100550844.3.7 m.15672 sp RS20_XENLA 92.308 117 7 2 4 118 3 119 1.01E-70 209 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P23403 CHOYP_LOC100550844.4.7 m.15873 sp RS20_XENLA 92.308 117 7 2 4 118 3 119 1.01E-70 209 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P25067 CHOYP_contig_042599 m.49086 sp CO8A2_HUMAN 33.846 130 70 7 66 184 576 700 1.01E-06 51.2 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; P26652 CHOYP_LOC100142611.1.2 m.26921 sp TIMP3_CHICK 33.775 151 92 4 5 151 10 156 1.01E-17 80.5 TIMP3_CHICK reviewed Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) 212 negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] GO:0002020; GO:0005578; GO:0005615; GO:0008191; GO:0010033; GO:0043086; GO:0046872; GO:0051045 0 0 0 PF00965; P28575 CHOYP_LOC100375964.1.1 m.15943 sp IPP_MOUSE 38.501 587 344 4 4 584 9 584 1.01E-152 454 IPP_MOUSE reviewed Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Murine IAP-promoted placenta-expressed protein) (Protein MIPP) Ipp Mipp Mus musculus (Mouse) 584 protein ubiquitination [GO:0016567] GO:0005737; GO:0005856; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; P50133 CHOYP_PTH1R.2.4 m.18685 sp PTH1R_PIG 37.531 397 220 11 45 421 80 468 1.01E-78 258 PTH1R_PIG reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Sus scrofa (Pig) 585 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular calcium ion homeostasis [GO:0006874]; chondrocyte differentiation [GO:0002062]; negative regulation of cell proliferation [GO:0008285]; osteoblast development [GO:0002076]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cell proliferation [GO:0008284] GO:0002062; GO:0002076; GO:0004991; GO:0005622; GO:0005887; GO:0006874; GO:0007166; GO:0007188; GO:0007189; GO:0007200; GO:0008284; GO:0008285; GO:0017046; GO:0030282; GO:0043621; GO:0045453; GO:0048469; GO:0070062 0 0 0 PF00002;PF02793; P52485 CHOYP_UBCD2.1.1 m.54558 sp UBCD2_DROME 88.608 158 18 0 53 210 75 232 1.01E-104 304 UBCD2_DROME reviewed Ubiquitin-conjugating enzyme E2-24 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) Ubc2 UbcD2 CG6720 Drosophila melanogaster (Fruit fly) 232 lipid storage [GO:0019915]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005524; GO:0019915 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; P53817 CHOYP_BRAFLDRAFT_119296.13.16 m.51500 sp HRSL3_RAT 38.75 160 87 5 14 170 3 154 1.01E-23 94.4 HRSL3_RAT reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein) Pla2g16 H-rev107 Hrasls3 Hrev107 Rattus norvegicus (Rat) 160 lipid catabolic process [GO:0016042]; negative regulation of cell cycle [GO:0045786]; phospholipid biosynthetic process [GO:0008654] GO:0004623; GO:0005737; GO:0005783; GO:0008654; GO:0008970; GO:0016020; GO:0016021; GO:0016042; GO:0045786; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; P54316 CHOYP_LOC100745181.1.1 m.48589 sp LIPR1_RAT 37.891 256 157 1 11 266 50 303 1.01E-52 181 LIPR1_RAT reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) Pnliprp1 Plrp1 Rattus norvegicus (Rat) 473 lipid metabolic process [GO:0006629]; pancreas development [GO:0031016]; response to glucocorticoid [GO:0051384]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005509; GO:0005615; GO:0006629; GO:0016298; GO:0031016; GO:0043434; GO:0051384 0 0 0 PF00151;PF01477; P61621 CHOYP_S61A1.2.3 m.54857 sp S61A1_RAT 53.233 464 196 2 147 589 3 466 1.01E-162 476 S61A1_RAT reviewed Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) Sec61a1 Sec61a Rattus norvegicus (Rat) 476 cell growth [GO:0016049]; endoplasmic reticulum organization [GO:0007029]; posttranslational protein targeting to membrane [GO:0006620]; response to interferon-gamma [GO:0034341]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005789; GO:0005791; GO:0006614; GO:0006620; GO:0007029; GO:0016021; GO:0016049; GO:0034341; GO:0043022 0 0 0 PF10559;PF00344; P80928 CHOYP_MIF.2.2 m.30795 sp MIF_PIG 31.633 98 66 1 30 127 5 101 1.01E-11 60.8 MIF_PIG reviewed Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Sus scrofa (Pig) 115 "cell aging [GO:0007569]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of cell aging [GO:0090344]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cellular protein metabolic process [GO:0032269]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of myeloid cell apoptotic process [GO:0033033]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of myeloid leukocyte cytokine production involved in immune response [GO:0061081]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of prostaglandin secretion involved in immune response [GO:0061078]; positive regulation of protein kinase A signaling [GO:0010739]; prostaglandin biosynthetic process [GO:0001516]; protein homotrimerization [GO:0070207]" GO:0001516; GO:0002906; GO:0004167; GO:0005615; GO:0005654; GO:0005737; GO:0006954; GO:0007166; GO:0007569; GO:0008283; GO:0009986; GO:0010629; GO:0010739; GO:0030330; GO:0030890; GO:0031666; GO:0032269; GO:0033033; GO:0033138; GO:0042056; GO:0043209; GO:0043406; GO:0043518; GO:0045087; GO:0048146; GO:0050178; GO:0050715; GO:0050731; GO:0061078; GO:0061081; GO:0070062; GO:0070207; GO:0070374; GO:0071157; GO:0090238; GO:0090344; GO:1902166; GO:2000343 0 0 0 PF01187; Q04336 CHOYP_LOC101242064.1.1 m.29867 sp YM54_YEAST 64.815 108 38 0 2 109 11 118 1.01E-42 151 YM54_YEAST reviewed Uncharacterized protein YMR196W YMR196W YM9646.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1088 oligosaccharide metabolic process [GO:0009311]; protein N-linked glycosylation [GO:0006487] GO:0004573; GO:0006487; GO:0009311 0 0 0 0 Q07263 CHOYP_CHRNA2.1.1 m.60696 sp ACHA3_BOVIN 30.189 318 212 5 25 335 19 333 1.01E-38 148 ACHA3_BOVIN reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Bos taurus (Bovine) 495 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; Q09575 CHOYP_LOC100489570.1.1 m.33977 sp YRD6_CAEEL 30.303 330 215 8 185 503 752 1077 1.01E-38 156 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q09575 CHOYP_LOC100892528.1.1 m.707 sp YRD6_CAEEL 32.059 340 222 5 146 478 717 1054 1.01E-43 171 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q09654 CHOYP_LOC100368020.21.29 m.32973 sp TRI23_CAEEL 25.962 208 121 10 1 186 118 314 1.01E-06 52 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q09654 CHOYP_LOC100373444.59.79 m.54129 sp TRI23_CAEEL 31.897 116 72 4 11 119 106 221 1.01E-07 57.8 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q14314 CHOYP_BRAFLDRAFT_148190.1.1 m.32227 sp FGL2_HUMAN 43.386 189 102 2 99 287 211 394 1.01E-42 155 FGL2_HUMAN reviewed Fibroleukin (Fibrinogen-like protein 2) (pT49) FGL2 Homo sapiens (Human) 439 0 GO:0005577; GO:0008233; GO:0070062 0 0 0 PF00147; Q14674 CHOYP_LOC576865.1.1 m.24520 sp ESPL1_HUMAN 32.322 659 385 18 1669 2295 1491 2120 1.01E-84 314 ESPL1_HUMAN reviewed Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) ESPL1 ESP1 KIAA0165 Homo sapiens (Human) 2120 apoptotic process [GO:0006915]; cytokinesis [GO:0000910]; establishment of mitotic spindle localization [GO:0040001]; homologous chromosome segregation [GO:0045143]; meiotic chromosome separation [GO:0051307]; meiotic spindle organization [GO:0000212]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of sister chromatid cohesion [GO:0045875]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of mitotic sister chromatid separation [GO:1901970] GO:0000070; GO:0000212; GO:0000910; GO:0003824; GO:0004197; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0006915; GO:0008234; GO:0040001; GO:0045143; GO:0045842; GO:0045875; GO:0051307; GO:0072686; GO:1901970 0 0 0 PF03568; Q16534 CHOYP_LOC101078755.1.1 m.29533 sp HLF_HUMAN 65.217 115 40 0 240 354 175 289 1.01E-46 163 HLF_HUMAN reviewed Hepatic leukemia factor HLF Homo sapiens (Human) 295 multicellular organism development [GO:0007275]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000977; GO:0001077; GO:0003677; GO:0003690; GO:0005634; GO:0006366; GO:0007275; GO:0035914; GO:0048511 0 0 0 PF07716; Q1HCL7 CHOYP_LOC100902912.1.1 m.9008 sp NAKD2_RAT 47.927 386 189 5 44 427 49 424 1.01E-123 368 NAKD2_RAT reviewed "NAD kinase 2, mitochondrial (EC 2.7.1.23) (Mitochondrial NAD kinase) (NAD kinase domain-containing protein 1, mitochondrial)" Nadk2 Mnadk Nadkd1 Rattus norvegicus (Rat) 425 NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] GO:0003951; GO:0005524; GO:0005739; GO:0006741; GO:0019674; GO:0042803 0 0 0 PF01513; Q1HQF8 CHOYP_LOC100049762.1.1 m.1777 sp KTAP2_AEDAE 52.985 134 60 1 28 161 1 131 1.01E-41 139 KTAP2_AEDAE reviewed Protein KRTCAP2 homolog AAEL007634 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 132 0 GO:0005615; GO:0016021 0 0 0 PF09775; Q1T769 CHOYP_LOC762503.1.1 m.62567 sp MIS12_CHICK 26.289 194 139 1 42 231 8 201 1.01E-17 81.6 MIS12_CHICK reviewed Protein MIS12 homolog MIS12 Gallus gallus (Chicken) 210 cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070]; protein localization to kinetochore [GO:0034501] GO:0000070; GO:0000444; GO:0000818; GO:0007059; GO:0034501; GO:0051301; GO:0051382 0 0 0 PF05859; Q2HJ98 CHOYP_LOC581398.2.2 m.28962 sp FAHD1_BOVIN 55.814 215 95 0 2 216 3 217 1.01E-91 271 FAHD1_BOVIN reviewed "Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.3)" FAHD1 Bos taurus (Bovine) 221 metabolic process [GO:0008152] GO:0005654; GO:0005739; GO:0005743; GO:0005829; GO:0008152; GO:0008948; GO:0018773; GO:0034545; GO:0046872; GO:0047621 0 0 0 PF01557; Q2YDD0 CHOYP_HSP7E.1.1 m.13730 sp HSP7E_BOVIN 42.913 515 279 5 9 514 1 509 1.01E-140 418 HSP7E_BOVIN reviewed Heat shock 70 kDa protein 14 HSPA14 Bos taurus (Bovine) 509 0 GO:0005524; GO:0005829; GO:0005840; GO:0016020 0 0 0 PF00012; Q32L68 CHOYP_BRAFLDRAFT_130806.2.2 m.54917 sp HM20B_BOVIN 29.787 141 81 6 50 179 8 141 1.01E-08 57.8 HM20B_BOVIN reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (HMG box-containing protein 20B) HMG20B SMARCE1R Bos taurus (Bovine) 317 "cell cycle [GO:0007049]; covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007049; GO:0016569 0 0 0 PF00505; Q3TZ65 CHOYP_LOC100368464.2.2 m.45782 sp OD3L2_MOUSE 41.818 110 63 1 1 110 26 134 1.01E-18 82 OD3L2_MOUSE reviewed Outer dense fiber protein 3-like protein 2 Odf3l2 Gm1157 Mus musculus (Mouse) 277 0 GO:0005881 0 0 0 PF07004; Q3UIR3 CHOYP_LOC100368715.2.3 m.51732 sp DTX3L_MOUSE 54.359 195 88 1 571 765 555 748 1.01E-58 216 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q3UJZ3 CHOYP_BRAFLDRAFT_100948.1.1 m.43000 sp ARMC7_MOUSE 58.989 178 70 2 9 184 4 180 1.01E-75 228 ARMC7_MOUSE reviewed Armadillo repeat-containing protein 7 Armc7 Mus musculus (Mouse) 198 0 GO:0005634; GO:0005737 0 0 0 PF00514; Q3UZ01 CHOYP_RNPC3.1.1 m.28839 sp RBM40_MOUSE 40.873 504 255 14 10 487 28 514 1.01E-98 309 RBM40_MOUSE reviewed RNA-binding protein 40 (RNA-binding motif protein 40) (RNA-binding region-containing protein 3) Rnpc3 Kiaa1839 Rbm40 Mus musculus (Mouse) 514 "developmental process [GO:0032502]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0005634; GO:0005654; GO:0005689; GO:0030626; GO:0032502; GO:0097157 0 0 0 PF00076; Q4ZHW1 CHOYP_LOC100567969.1.1 m.26461 sp PTF1A_XENLA 47.368 152 61 7 54 198 118 257 1.01E-26 105 PTF1A_XENLA reviewed Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (Transcription factor Ptf1a/p48) ptf1a Xenopus laevis (African clawed frog) 270 "embryo development [GO:0009790]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; hindbrain development [GO:0030902]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0009790; GO:0009888; GO:0030902; GO:0031017; GO:0045893; GO:0048384; GO:0048699 0 0 0 PF00010; Q502M6 CHOYP_LOC100635111.4.13 m.13645 sp ANR29_DANRE 38.393 224 137 1 907 1130 43 265 1.01E-40 155 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q568M3 CHOYP_CRLF3.1.2 m.8760 sp CRLF3_DANRE 33.619 467 261 7 2 447 5 443 1.01E-83 267 CRLF3_DANRE reviewed Cytokine receptor-like factor 3 (Clf-3 protein) crlf3 clf-3 zgc:110212 Danio rerio (Zebrafish) (Brachydanio rerio) 444 0 GO:0005737 0 0 0 0 Q569T7 CHOYP_BRAFLDRAFT_85464.2.2 m.53992 sp MFS4B_XENLA 41.096 146 86 0 49 194 1 146 1.01E-32 136 MFS4B_XENLA reviewed Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) mfsd4b naglt1 Xenopus laevis (African clawed frog) 491 carbohydrate transport [GO:0008643]; sodium ion transport [GO:0006814] GO:0006814; GO:0008643; GO:0015293; GO:0016021; GO:0016324 0 0 cd06174; PF07690; Q5BIM1 CHOYP_LOC100376215.3.19 m.20636 sp TRI45_BOVIN 33.333 117 72 4 13 125 127 241 1.01E-08 56.2 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5RBX0 CHOYP_LOC100575484.1.1 m.18147 sp ZNF7_PONAB 26.866 402 240 8 704 1101 252 603 1.01E-35 149 ZNF7_PONAB reviewed Zinc finger protein 7 ZNF7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 686 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q5RFR0 CHOYP_TTPAL.2.2 m.38006 sp TTPAL_PONAB 53.472 144 66 1 11 153 31 174 1.01E-44 153 TTPAL_PONAB reviewed Alpha-tocopherol transfer protein-like TTPAL Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 342 0 GO:0005215; GO:0005622; GO:0016020 0 0 0 PF00650;PF03765; Q5U458 CHOYP_DNAJC11.1.1 m.1818 sp DJC11_MOUSE 39.683 567 314 12 1 553 1 553 1.01E-123 378 DJC11_MOUSE reviewed DnaJ homolog subfamily C member 11 Dnajc11 Mus musculus (Mouse) 559 0 GO:0005739; GO:0005743; GO:0070062 0 0 cd06257; PF00226;PF11875; Q5ZT34 CHOYP_LOC574855.4.9 m.22339 sp BIOC_LEGPH 31.959 97 63 1 162 258 46 139 1.01E-06 53.1 BIOC_LEGPH reviewed Malonyl-[acyl-carrier protein] O-methyltransferase (Malonyl-ACP O-methyltransferase) (EC 2.1.1.197) (Biotin synthesis protein BioC) bioC lpg2331 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 284 biotin biosynthetic process [GO:0009102] GO:0009102; GO:0010340 PATHWAY: Cofactor biosynthesis; biotin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00835}. 0 0 PF08241; Q60787 CHOYP_LCP2.6.14 m.20053 sp LCP2_MOUSE 35.556 135 84 2 33 164 389 523 1.01E-20 91.3 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q60HG0 CHOYP_FKTN.1.1 m.8694 sp FKTN_MACFA 41.649 461 231 13 6 436 9 461 1.01E-109 334 FKTN_MACFA reviewed Fukutin (EC 2.-.-.-) FKTN FCMD QmoA-10950 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 461 protein O-linked mannosylation [GO:0035269] GO:0000139; GO:0005794; GO:0005801; GO:0016021; GO:0016740; GO:0035269 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:O75072}. 0 0 PF04991; Q63072 CHOYP_TTC1.1.2 m.53161 sp BST1_RAT 31.336 217 139 5 24 239 48 255 1.01E-27 111 BST1_RAT reviewed ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPr hydrolase 2) (CD antigen CD157) Bst1 Rattus norvegicus (Rat) 319 positive regulation of B cell proliferation [GO:0030890] GO:0003953; GO:0005886; GO:0016740; GO:0016849; GO:0030890; GO:0031225; GO:0050135 0 0 0 PF02267; Q66IZ5 CHOYP_TAD3B.1.1 m.12835 sp TAD3B_XENLA 50.567 441 195 7 11 441 5 432 1.01E-137 405 TAD3B_XENLA reviewed Transcriptional adapter 3-B (ADA3 homolog B) (Transcriptional adapter 3-like B) (ADA3-like protein B) tada3-b ada3-b tada3l-b Xenopus laevis (African clawed frog) 432 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF10198; Q69Z37 CHOYP_LOC100368251.4.6 m.51899 sp SAM9L_MOUSE 25.834 1529 936 59 730 2166 138 1560 1.01E-99 360 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6DIB5 CHOYP_MEG10.65.91 m.51004 sp MEG10_MOUSE 35.361 526 265 26 4 483 246 742 1.01E-56 209 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6NZL8 CHOYP_EIN_201030.1.3 m.20334 sp SCUB1_MOUSE 33.702 181 113 5 28 202 645 824 1.01E-12 76.3 SCUB1_MOUSE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) 1018 protein homooligomerization [GO:0051260] GO:0005509; GO:0005615; GO:0009897; GO:0009986; GO:0019897; GO:0046982; GO:0051260 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q6PDJ1 CHOYP_CAHD1.2.6 m.22633 sp CAHD1_MOUSE 26.673 1046 676 36 26 1007 59 1077 1.01E-90 321 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6UXP7 CHOYP_LOC100073258.1.1 m.6460 sp F151B_HUMAN 38.983 236 138 4 84 318 28 258 1.01E-46 167 F151B_HUMAN reviewed Protein FAM151B FAM151B UNQ9217/PRO28685 Homo sapiens (Human) 276 0 0 0 0 0 PF10223; Q86Y13 CHOYP_NEMVEDRAFT_V1G247590.7.13 m.50805 sp DZIP3_HUMAN 26.174 149 103 3 22 164 393 540 1.01E-06 54.3 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8HY87 CHOYP_LOC100164297.1.1 m.9914 sp RNZ2_MACFA 29.814 322 204 11 48 353 445 760 1.01E-34 139 RNZ2_MACFA reviewed Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) ELAC2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 826 "mitochondrial tRNA 3'-trailer cleavage, endonucleolytic [GO:0072684]" GO:0004519; GO:0005634; GO:0005739; GO:0046872; GO:0072684 0 0 0 PF12706;PF13691; Q8K430 CHOYP_BRAFLDRAFT_119002.1.1 m.34140 sp KLH17_RAT 32.075 212 136 4 24 235 80 283 1.01E-23 109 KLH17_RAT reviewed Kelch-like protein 17 (Actinfilin) Klhl17 Rattus norvegicus (Rat) 640 actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; protein ubiquitination [GO:0016567] GO:0005615; GO:0007420; GO:0014069; GO:0015629; GO:0016567; GO:0030036; GO:0030054; GO:0031208; GO:0031463; GO:0032839; GO:0032947; GO:0043025; GO:0045211; GO:0051015 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q8N895 CHOYP_ZNF710.1.2 m.11913 sp ZN366_HUMAN 43.213 361 137 8 40 339 189 542 1.01E-87 281 ZN366_HUMAN reviewed Zinc finger protein 366 ZNF366 Homo sapiens (Human) 744 "negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; response to estrogen [GO:0043627]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003714; GO:0005634; GO:0006351; GO:0030331; GO:0033147; GO:0043627; GO:0046872 0 0 0 PF00096;PF13912; Q8NA31 CHOYP_CCD79.1.1 m.48486 sp TERB1_HUMAN 33.143 350 209 7 6 342 53 390 1.01E-45 174 TERB1_HUMAN reviewed Telomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79) CCDC79 TERB1 Homo sapiens (Human) 727 meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; synapsis [GO:0007129] GO:0000781; GO:0000784; GO:0003677; GO:0005637; GO:0007129; GO:0045141; GO:0070197 0 0 0 PF00249; Q8Q0U0 CHOYP_TVAG_327050.1.1 m.44006 sp Y045_METMA 31.25 256 171 3 13 266 83 335 1.01E-29 120 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q8QGW7 CHOYP_TGRB1.1.1 m.8982 sp LITAF_CHICK 36.667 90 51 2 7 96 46 129 1.01E-07 50.4 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8R242 CHOYP_CTBS.1.1 m.54468 sp DIAC_MOUSE 26.149 348 228 13 25 366 25 349 1.01E-24 108 DIAC_MOUSE reviewed Di-N-acetylchitobiase (EC 3.2.1.-) Ctbs Mus musculus (Mouse) 366 chitin catabolic process [GO:0006032]; oligosaccharide catabolic process [GO:0009313] GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0006032; GO:0008061; GO:0009313; GO:0070062 0 0 0 PF00704; Q8STF0 CHOYP_TSP_03217.1.1 m.12987 sp CALM_STRIE 93.571 140 9 0 8 147 12 151 1.01E-90 263 CALM_STRIE reviewed Calmodulin (CaM) 0 Strongylocentrotus intermedius (Sea urchin) 156 0 GO:0005509 0 0 0 PF13499; Q8WVZ9 CHOYP_BACH1.14.17 m.30586 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 1.01E-08 62 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q91W45 CHOYP_PAIP2.1.1 m.4990 sp PAI2B_MOUSE 38.298 94 43 4 26 107 44 134 1.01E-08 52.8 PAI2B_MOUSE reviewed Polyadenylate-binding protein-interacting protein 2B (PABP-interacting protein 2B) (PAIP-2B) (Poly(A)-binding protein-interacting protein 2B) Paip2b Kiaa1155 Mus musculus (Mouse) 136 negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947] GO:0000900; GO:0008143; GO:0017148; GO:0045947 0 0 0 PF07145; Q95JY5 CHOYP_SAMD15.1.1 m.27733 sp SAM15_MACFA 55.66 106 47 0 20 125 536 641 1.01E-32 124 SAM15_MACFA reviewed Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15) SAMD15 QtsA-12354 QtsA-15642 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 667 0 0 0 0 0 PF00536; Q96GG9 CHOYP_ISCW_ISCW023153.1.1 m.10480 sp DCNL1_HUMAN 69.498 259 77 2 1 257 1 259 1.01E-136 388 DCNL1_HUMAN reviewed DCN1-like protein 1 (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene) DCUN1D1 DCUN1L1 RP42 SCCRO Homo sapiens (Human) 259 positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein neddylation [GO:0045116] GO:0000151; GO:0005634; GO:0031624; GO:0032182; GO:0045116; GO:0051443; GO:0097602 0 0 0 PF03556; Q96MM6 CHOYP_BRAFLDRAFT_208293.7.20 m.39149 sp HS12B_HUMAN 36.103 349 167 11 11 306 61 406 1.01E-49 178 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99549 CHOYP_LOC100372844.2.2 m.58005 sp MPP8_HUMAN 36.391 327 202 3 506 827 534 859 1.01E-58 218 MPP8_HUMAN reviewed M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) MPHOSPH8 MPP8 Homo sapiens (Human) 860 "negative regulation of transcription, DNA-templated [GO:0045892]; regulation of DNA methylation [GO:0044030]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000788; GO:0004842; GO:0005634; GO:0005720; GO:0005730; GO:0005737; GO:0005886; GO:0006351; GO:0031625; GO:0035064; GO:0044030; GO:0045892; GO:0070062 0 0 0 PF12796;PF00385; Q99973 CHOYP_BRAFLDRAFT_128562.2.4 m.33663 sp TEP1_HUMAN 32.836 1072 654 29 12 1057 630 1661 1.01E-152 507 TEP1_HUMAN reviewed Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) 2627 telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000781; GO:0002039; GO:0003720; GO:0003723; GO:0005524; GO:0005697; GO:0005737; GO:0016363; GO:0019899; GO:0030529; GO:0070034 0 0 0 PF13271;PF05386;PF05731;PF00400; Q99973 CHOYP_TRIADDRAFT_61017.1.1 m.31912 sp TEP1_HUMAN 29.137 278 174 7 133 392 1163 1435 1.01E-18 92.4 TEP1_HUMAN reviewed Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) 2627 telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000781; GO:0002039; GO:0003720; GO:0003723; GO:0005524; GO:0005697; GO:0005737; GO:0016363; GO:0019899; GO:0030529; GO:0070034 0 0 0 PF13271;PF05386;PF05731;PF00400; Q99N85 CHOYP_LOC100115506.2.2 m.63432 sp RT18A_MOUSE 41.748 103 51 3 40 140 39 134 1.01E-19 84.3 RT18A_MOUSE reviewed "28S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (28S ribosomal protein S18-3, mitochondrial) (MRP-S18-3)" Mrps18a Mus musculus (Mouse) 196 mitochondrial translation [GO:0032543] GO:0003735; GO:0005739; GO:0005763; GO:0022627; GO:0032543 0 0 0 PF01084; Q9C0H5 CHOYP_BRAFLDRAFT_102618.1.1 m.1758 sp RHG39_HUMAN 56.129 465 192 6 694 1152 625 1083 1.01E-170 535 RHG39_HUMAN reviewed Rho GTPase-activating protein 39 ARHGAP39 KIAA1688 Homo sapiens (Human) 1083 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005634; GO:0005829; GO:0005856; GO:0007165; GO:0051056 0 0 0 PF00784;PF00620;PF00397; Q9CZJ2 CHOYP_LOC770082.3.4 m.34164 sp HS12B_MOUSE 31.62 642 353 19 30 602 61 685 1.01E-93 305 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D8B1 CHOYP_AIG1.2.2 m.58575 sp AIG1_MOUSE 40.455 220 127 1 25 240 18 237 1.01E-57 187 AIG1_MOUSE reviewed Androgen-induced gene 1 protein (AIG-1) Aig1 Mus musculus (Mouse) 262 0 GO:0016021 0 0 0 PF04750; Q9EPA7 CHOYP_NMNA1.1.1 m.36046 sp NMNA1_MOUSE 51.761 284 123 3 23 303 4 276 1.01E-93 285 NMNA1_MOUSE reviewed Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) Nmnat1 D4Cole1e Nmnat Mus musculus (Mouse) 285 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; ATP generation from poly-ADP-D-ribose [GO:1990966]; NAD biosynthetic process [GO:0009435]; response to wounding [GO:0009611] GO:0000309; GO:0004515; GO:0005524; GO:0005634; GO:0009435; GO:0009611; GO:0034628; GO:1990966 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. 0 0 PF01467; Q9I7U4 CHOYP_LOC100375985.1.1 m.26416 sp TITIN_DROME 37.391 115 72 0 16 130 17829 17943 1.01E-17 83.2 TITIN_DROME reviewed Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) 18141 cell division [GO:0051301]; locomotion [GO:0040011]; mesoderm development [GO:0007498]; mitotic chromosome condensation [GO:0007076]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; regulation of hemocyte proliferation [GO:0035206]; sarcomere organization [GO:0045214]; sensory perception of pain [GO:0019233]; sister chromatid cohesion [GO:0007062]; skeletal muscle tissue development [GO:0007519]; somatic muscle development [GO:0007525]; visceral muscle development [GO:0007522] GO:0000794; GO:0003779; GO:0005863; GO:0005875; GO:0007062; GO:0007076; GO:0007498; GO:0007517; GO:0007519; GO:0007520; GO:0007522; GO:0007525; GO:0008307; GO:0016203; GO:0019233; GO:0030017; GO:0030018; GO:0031674; GO:0035206; GO:0040011; GO:0045214; GO:0051301 0 0 0 PF06582;PF00041;PF07679;PF00018; Q9JHG3 CHOYP_LOC100367457.1.1 m.66502 sp APJ_RAT 26.923 260 155 15 7 246 4 248 1.01E-06 54.3 APJ_RAT reviewed Apelin receptor (Angiotensin receptor-like 1) (B78) (G-protein coupled receptor APJ) (GPCR34) Aplnr Agtrl1 Apj Rattus norvegicus (Rat) 377 gastrulation [GO:0007369]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; regulation of body fluid levels [GO:0050878] GO:0004930; GO:0005886; GO:0007186; GO:0007369; GO:0007507; GO:0016020; GO:0016021; GO:0042277; GO:0050878 0 0 0 PF00001; Q9NSD4 CHOYP_LOC100697844.1.1 m.6555 sp ZN275_HUMAN 28.994 169 107 4 1005 1169 237 396 1.01E-07 59.7 ZN275_HUMAN reviewed Zinc finger protein 275 ZNF275 Homo sapiens (Human) 429 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q9UBC0 CHOYP_ONEC2.2.3 m.35956 sp HNF6_HUMAN 28.108 185 125 4 127 307 261 441 1.01E-09 65.1 HNF6_HUMAN reviewed Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1) ONECUT1 HNF6 HNF6A Homo sapiens (Human) 465 "B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cilium assembly [GO:0042384]; endocrine pancreas development [GO:0031018]; endoderm development [GO:0007492]; epithelial cell development [GO:0002064]; glucose metabolic process [GO:0006006]; liver development [GO:0001889]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; Notch signaling pathway [GO:0007219]; positive regulation of cell migration [GO:0030335]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]; regulation of transcription, DNA-templated [GO:0006355]; spleen development [GO:0048536]; system development [GO:0048731]" GO:0001077; GO:0001889; GO:0001952; GO:0002064; GO:0003677; GO:0005634; GO:0006006; GO:0006355; GO:0007219; GO:0007492; GO:0030154; GO:0030183; GO:0030335; GO:0030512; GO:0031018; GO:0042384; GO:0045165; GO:0045944; GO:0048536; GO:0048731 0 0 0 PF02376;PF00046; Q9UJT9 CHOYP_SMP_176410.1.1 m.18565 sp FBXL7_HUMAN 23.324 343 218 10 30 362 113 420 1.01E-12 73.9 FBXL7_HUMAN reviewed F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) 491 cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000086; GO:0000151; GO:0004842; GO:0005737; GO:0005813; GO:0006511; GO:0007067; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q9UL16 CHOYP_LOC100367739.1.1 m.22741 sp CFA45_HUMAN 46.881 561 282 4 33 591 1 547 1.01E-128 391 CFA45_HUMAN reviewed Cilia- and flagella-associated protein 45 (Coiled-coil domain-containing protein 19) (Nasopharyngeal epithelium-specific protein 1) CFAP45 CCDC19 NESG1 Homo sapiens (Human) 551 0 GO:0005634; GO:0005654; GO:0005929 0 0 0 0 Q9VPH7 CHOYP_AAEL_AAEL011742.1.1 m.27651 sp ERF1_DROME 62.676 142 50 2 2 142 299 438 1.01E-54 180 ERF1_DROME reviewed Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) eRF1 CG5605 Drosophila melanogaster (Fruit fly) 438 autophagic cell death [GO:0048102]; salivary gland cell autophagic cell death [GO:0035071]; smoothened signaling pathway [GO:0007224]; translational termination [GO:0006415] GO:0005829; GO:0006415; GO:0007224; GO:0008079; GO:0016149; GO:0035071; GO:0048102 0 0 0 PF03463;PF03464;PF03465; A2AVA0 CHOYP_NEMVEDRAFT_V1G202195.4.4 m.64393 sp SVEP1_MOUSE 29.319 191 107 8 548 731 990 1159 1.02E-06 56.2 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A2RV80 CHOYP_LOC581215.1.1 m.66106 sp GRAM4_XENLA 29.31 522 317 12 50 554 76 562 1.02E-62 220 GRAM4_XENLA reviewed GRAM domain-containing protein 4 gramd4 Xenopus laevis (African clawed frog) 578 apoptotic process [GO:0006915] GO:0006915; GO:0016021; GO:0031966 0 0 0 PF02893; A4IF63 CHOYP_BRAFLDRAFT_206799.20.23 m.53339 sp TRIM2_BOVIN 34.483 87 55 2 30 115 622 707 1.02E-07 52 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_LOC100376214.8.11 m.53350 sp TRIM2_BOVIN 28.226 124 82 3 19 136 572 694 1.02E-07 53.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_CARNS1.6.6 m.64238 sp CRNS1_HUMAN 36.464 181 108 2 35 208 310 490 1.02E-33 131 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A6NI56 CHOYP_LOC580909.2.2 m.46066 sp CC154_HUMAN 21.358 604 400 14 197 758 74 644 1.02E-20 100 CC154_HUMAN reviewed Coiled-coil domain-containing protein 154 CCDC154 Homo sapiens (Human) 674 0 GO:0005769 0 0 0 PF15450; A8TX70 CHOYP_CO6A3.4.5 m.54225 sp CO6A5_HUMAN 21.437 807 548 28 364 1122 30 798 1.02E-33 146 CO6A5_HUMAN reviewed Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) 2615 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; D2GXS7 CHOYP_TRIM3.42.58 m.43450 sp TRIM2_AILME 24.116 311 189 10 215 486 442 744 1.02E-12 74.3 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E7FEC4 CHOYP_SVEP1.5.8 m.35492 sp SUSD4_DANRE 26.648 364 205 18 51 403 67 379 1.02E-12 73.9 SUSD4_DANRE reviewed Sushi domain-containing protein 4 susd4 Danio rerio (Zebrafish) (Brachydanio rerio) 484 chordate embryonic development [GO:0043009] GO:0016021; GO:0043009 0 0 0 PF00084; E9Q1U1 CHOYP_LOC100377810.1.1 m.44703 sp CC171_MOUSE 53.398 103 48 0 30 132 217 319 1.02E-26 108 CC171_MOUSE reviewed Coiled-coil domain-containing protein 171 Ccdc171 Mus musculus (Mouse) 1324 0 0 0 0 0 0 O15973 CHOYP_LOC100374980.1.2 m.38536 sp OPSD1_MIZYE 21.829 339 180 12 9 331 48 317 1.02E-06 53.9 OPSD1_MIZYE reviewed "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 499 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0004930; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; O75841 CHOYP_DMOJ_GI12939.1.3 m.5732 sp UPK1B_HUMAN 24.194 186 99 9 72 237 63 226 1.02E-06 52.4 UPK1B_HUMAN reviewed Uroplakin-1b (UP1b) (Tetraspanin-20) (Tspan-20) (Uroplakin Ib) (UPIb) UPK1B TSPAN20 Homo sapiens (Human) 260 cell surface receptor signaling pathway [GO:0007166]; epithelial cell differentiation [GO:0030855] GO:0005198; GO:0005887; GO:0007166; GO:0016021; GO:0016324; GO:0030855; GO:0070062 0 0 0 PF00335; O88799 CHOYP_contig_040513 m.45971 sp ZAN_MOUSE 26.053 380 237 15 103 439 553 931 1.02E-10 68.2 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; P00178 CHOYP_BRAFLDRAFT_289920.1.1 m.24219 sp CP2B4_RABIT 29.505 444 297 10 38 471 29 466 1.02E-53 191 CP2B4_RABIT reviewed Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1) CYP2B4 Oryctolagus cuniculus (Rabbit) 491 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P04323 CHOYP_LOC100368444.1.2 m.17677 sp POL3_DROME 40.732 437 245 6 379 808 194 623 1.02E-100 338 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P09057 CHOYP_LOC100374422.1.2 m.26377 sp DCOR_RAT 56.397 383 162 3 37 416 37 417 1.02E-151 442 DCOR_RAT reviewed Ornithine decarboxylase (ODC) (EC 4.1.1.17) Odc1 Odc Rattus norvegicus (Rat) 461 kidney development [GO:0001822]; polyamine metabolic process [GO:0006595]; positive regulation of cell proliferation [GO:0008284]; putrescine biosynthetic process [GO:0009446]; putrescine biosynthetic process from ornithine [GO:0033387]; regulation of protein catabolic process [GO:0042176]; response to virus [GO:0009615] GO:0001822; GO:0004586; GO:0005737; GO:0005829; GO:0006595; GO:0008284; GO:0009446; GO:0009615; GO:0033387; GO:0042176; GO:0042803; GO:0048471 PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. 0 0 PF02784;PF00278; P15146 CHOYP_LOC100729384.1.1 m.1528 sp MTAP2_RAT 45.455 132 69 3 248 377 1673 1803 1.02E-22 104 MTAP2_RAT reviewed Microtubule-associated protein 2 (MAP-2) Map2 Mtap2 Rattus norvegicus (Rat) 1861 central nervous system neuron development [GO:0021954]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570] GO:0000226; GO:0001578; GO:0005790; GO:0005791; GO:0005874; GO:0005875; GO:0008017; GO:0021954; GO:0030425; GO:0031175; GO:0032355; GO:0032570; GO:0043005; GO:0043025; GO:0043234 0 0 0 PF08377;PF00418; P20664 CHOYP_LOC586401.2.2 m.18274 sp PRI1_MOUSE 58.057 422 160 7 7 419 4 417 1.02E-175 499 PRI1_MOUSE reviewed DNA primase small subunit (EC 2.7.7.-) (DNA primase 49 kDa subunit) (p49) Prim1 Mus musculus (Mouse) 417 0 GO:0003896; GO:0016020; GO:0046872; GO:1990077 0 0 cd04860; PF01896; P22059 CHOYP_LOC100372322.1.1 m.66893 sp OSBP1_HUMAN 56.41 273 111 2 83 349 537 807 1.02E-103 325 OSBP1_HUMAN reviewed Oxysterol-binding protein 1 OSBP OSBP1 Homo sapiens (Human) 807 positive regulation of growth of symbiont in host [GO:0044128]; sterol transport [GO:0015918] GO:0000139; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0008142; GO:0015248; GO:0015918; GO:0016020; GO:0019904; GO:0030054; GO:0044128; GO:0048471; GO:0070273 0 0 0 PF01237;PF00169; P24081 CHOYP_LOC100574426.1.2 m.34302 sp AN_NPVOP 26.25 240 128 9 16 232 36 249 1.02E-08 58.5 AN_NPVOP reviewed Alkaline nuclease (AN) (EC 3.1.-.-) ALK-EXO ORF131 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) 424 0 GO:0003677; GO:0004519; GO:0004527; GO:0042025 0 0 0 PF01771; P28827 CHOYP_PTPRZ.4.9 m.21524 sp PTPRM_HUMAN 32.342 538 317 13 432 937 880 1402 1.02E-70 260 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P29190 CHOYP_PCK-1.1.1 m.1479 sp PCKG_HAECO 67.742 186 59 1 1 186 165 349 1.02E-87 276 PCKG_HAECO reviewed Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) PEPCK Haemonchus contortus (Barber pole worm) 619 gluconeogenesis [GO:0006094] GO:0004613; GO:0005525; GO:0006094; GO:0046872 0 0 0 PF00821; P29594 CHOYP_LOC100136676.2.2 m.47008 sp CASP2_MOUSE 27.136 398 247 9 40 408 65 448 1.02E-38 148 CASP2_MOUSE reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Casp2 Ich1 Nedd-2 Nedd2 Mus musculus (Mouse) 452 "aging [GO:0007568]; apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]" GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0006977; GO:0007420; GO:0007568; GO:0016020; GO:0016485; GO:0019904; GO:0035234; GO:0043065; GO:0043066; GO:0043525; GO:0071260; GO:0097153; GO:0097190; GO:0097192; GO:2001235 0 0 0 PF00619; P35329 CHOYP_LOAG_01214.1.1 m.17390 sp CD22_MOUSE 25.467 428 288 17 57 470 208 618 1.02E-19 98.2 CD22_MOUSE reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) Cd22 Lyb-8 Siglec2 Mus musculus (Mouse) 862 cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007155; GO:0007166; GO:0009897; GO:0015026; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P35442 CHOYP_MANA.3.3 m.29186 sp TSP2_HUMAN 39.844 128 69 2 3 122 467 594 1.02E-20 91.7 TSP2_HUMAN reviewed Thrombospondin-2 THBS2 TSP2 Homo sapiens (Human) 1172 cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965] GO:0005509; GO:0005576; GO:0005604; GO:0007155; GO:0008201; GO:0016525; GO:0031091; GO:0051965 0 0 0 PF12947;PF07645;PF00090;PF02412;PF05735;PF00093; P40305 CHOYP_LUL4.2.2 m.59247 sp IFI27_HUMAN 52.632 95 33 2 143 237 35 117 1.02E-16 77.8 IFI27_HUMAN reviewed "Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a))" IFI27 Homo sapiens (Human) 119 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of protein export from nucleus [GO:0046825]; type I interferon signaling pathway [GO:0060337] GO:0000122; GO:0001102; GO:0005521; GO:0005637; GO:0005739; GO:0005741; GO:0006919; GO:0016021; GO:0046825; GO:0060337; GO:0097190 0 0 0 PF06140; P42026 CHOYP_LOC732995.1.2 m.36033 sp NDUS7_BOVIN 86.301 73 10 0 1 73 144 216 1.02E-40 136 NDUS7_BOVIN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) 216 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005747; GO:0008137; GO:0032981; GO:0046872; GO:0048038; GO:0051539 0 0 0 PF01058; P42026 CHOYP_LOC732995.2.2 m.36886 sp NDUS7_BOVIN 86.301 73 10 0 1 73 144 216 1.02E-40 136 NDUS7_BOVIN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) 216 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005747; GO:0008137; GO:0032981; GO:0046872; GO:0048038; GO:0051539 0 0 0 PF01058; P43307 CHOYP_LOC100371575.1.1 m.10551 sp SSRA_HUMAN 46.897 290 133 10 15 300 14 286 1.02E-69 221 SSRA_HUMAN reviewed Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) SSR1 TRAPA PSEC0262 Homo sapiens (Human) 286 cotranslational protein targeting to membrane [GO:0006613]; IRE1-mediated unfolded protein response [GO:0036498]; positive regulation of cell proliferation [GO:0008284] GO:0005783; GO:0005789; GO:0006613; GO:0008284; GO:0016021; GO:0036498 0 0 0 PF03896; P49321 CHOYP_LOC100376610.3.3 m.19689 sp NASP_HUMAN 43.726 263 112 9 102 342 510 758 1.02E-55 198 NASP_HUMAN reviewed Nuclear autoantigenic sperm protein (NASP) NASP Homo sapiens (Human) 788 blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone exchange [GO:0043486]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574] GO:0000790; GO:0001824; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006334; GO:0006335; GO:0006336; GO:0007049; GO:0008283; GO:0008584; GO:0015031; GO:0032403; GO:0033574; GO:0043234; GO:0043486; GO:0051879 0 0 0 PF10516; P51947 CHOYP_AGAP_AGAP008417.1.1 m.9149 sp CCNH_XENLA 44.41 322 172 2 1 319 1 318 1.02E-85 264 CCNH_XENLA reviewed Cyclin-H (MO15-associated protein) (p36) ccnh Xenopus laevis (African clawed frog) 323 "cell cycle [GO:0007049]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0007049; GO:0016538; GO:0070985 0 0 0 PF16899;PF00134; P51957 CHOYP_NEK4.2.8 m.15320 sp NEK4_HUMAN 43.75 256 141 3 42 294 11 266 1.02E-65 235 NEK4_HUMAN reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) 841 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; P91924 CHOYP_ACT.15.27 m.41972 sp ARF_DUGJA 57.258 124 53 0 4 127 59 182 1.02E-51 164 ARF_DUGJA reviewed ADP-ribosylation factor 0 Dugesia japonica (Planarian) 183 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q02357 CHOYP_TVAG_168010.19.45 m.39669 sp ANK1_MOUSE 37.383 214 134 0 1 214 229 442 1.02E-37 142 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q0VA77 CHOYP_ENPP4.1.1 m.9980 sp ENPP4_XENTR 36.222 450 250 15 34 481 27 441 1.02E-82 266 ENPP4_XENTR reviewed Bis(5'-adenosyl)-triphosphatase enpp4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4) enpp4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 452 blood coagulation [GO:0007596]; metabolic process [GO:0008152]; positive regulation of blood coagulation [GO:0030194] GO:0005886; GO:0007596; GO:0008152; GO:0016021; GO:0030194; GO:0046872; GO:0047710 0 0 0 PF01663; Q15056 CHOYP_EIF4H.3.3 m.57962 sp IF4H_HUMAN 46.403 278 107 8 2 273 1 242 1.02E-52 175 IF4H_HUMAN reviewed Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein) EIF4H KIAA0038 WBSCR1 WSCR1 Homo sapiens (Human) 248 cytoplasmic translation [GO:0002181]; developmental growth [GO:0048589]; eukaryotic translation initiation factor 4F complex assembly [GO:0097010]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; sexual reproduction [GO:0019953]; translational initiation [GO:0006413]; viral process [GO:0016032] GO:0000166; GO:0001731; GO:0002181; GO:0003723; GO:0003743; GO:0004386; GO:0005829; GO:0005844; GO:0005913; GO:0006413; GO:0006446; GO:0008135; GO:0016020; GO:0016032; GO:0016281; GO:0019953; GO:0033592; GO:0034057; GO:0043024; GO:0044822; GO:0048471; GO:0048589; GO:0097010; GO:0098641 0 0 0 PF00076; Q1WIM3 CHOYP_CEACAM1.1.3 m.49339 sp CADM3_RAT 24.291 247 167 10 88 331 71 300 1.02E-08 61.2 CADM3_RAT reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) Cadm3 Igsf4b Necl1 Rattus norvegicus (Rat) 396 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0042803; GO:0050839 0 0 0 PF08205;PF07679; Q1ZXH8 CHOYP_BRAFLDRAFT_90496.1.1 m.41132 sp GXCDD_DICDI 35.955 89 56 1 25 113 542 629 1.02E-07 53.9 GXCDD_DICDI reviewed Guanine exchange factor for Rac 30 gxcDD DDB_G0279733 Dictyostelium discoideum (Slime mold) 1632 aggregation involved in sorocarp development [GO:0031152]; intracellular signal transduction [GO:0035556]; regulation of Rho protein signal transduction [GO:0035023]; sorocarp development [GO:0030587] GO:0005089; GO:0005096; GO:0005737; GO:0005856; GO:0005938; GO:0016020; GO:0030587; GO:0030670; GO:0031152; GO:0032009; GO:0035023; GO:0035556; GO:0046872; GO:0048365 0 0 0 PF01412;PF00307;PF00169;PF00621; Q20930 CHOYP_LOAG_00377.2.4 m.54574 sp MIG17_CAEEL 36.929 241 130 13 291 516 227 460 1.02E-31 134 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q29R99 CHOYP_LOC588984.1.1 m.4779 sp LIPT2_DANRE 51.121 223 105 1 1 223 1 219 1.02E-80 244 LIPT2_DANRE reviewed "Putative lipoyltransferase 2, mitochondrial (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase)" lipt2 zgc:136925 Danio rerio (Zebrafish) (Brachydanio rerio) 224 lipoate biosynthetic process [GO:0009107]; protein lipoylation [GO:0009249] GO:0005739; GO:0009107; GO:0009249; GO:0016415; GO:0016874; GO:0033819 PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2. 0 0 PF03099; Q2NL11 CHOYP_LOC100378269.2.2 m.63234 sp CH074_BOVIN 27.604 192 132 3 2 189 68 256 1.02E-12 69.3 CH074_BOVIN reviewed Uncharacterized protein C8orf74 homolog 0 Bos taurus (Bovine) 293 0 0 0 0 0 PF14769; Q4KL91 CHOYP_AAEL_AAEL002214.1.2 m.15035 sp S36A4_XENLA 39.294 453 258 7 4 448 49 492 1.02E-97 306 S36A4_XENLA reviewed Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4) slc36a4 pat4 Xenopus laevis (African clawed frog) 522 amino acid transport [GO:0006865] GO:0006865; GO:0015293; GO:0016021 0 0 0 PF01490; Q4KLI9 CHOYP_PHUM_PHUM136920.1.1 m.63631 sp FBXW5_RAT 30.256 195 105 6 225 411 372 543 1.02E-13 76.6 FBXW5_RAT reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) 569 centrosome duplication [GO:0051298]; mitotic nuclear division [GO:0007067]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000151; GO:0005737; GO:0007067; GO:0010824; GO:0016567; GO:0019005; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q4P9K9 CHOYP_LOC100162079.1.4 m.13664 sp CHS8_USTMA 26.593 361 181 12 295 639 1431 1723 1.02E-23 112 CHS8_USTMA reviewed Chitin synthase 8 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 8) (Myosin chitin synthase 1) CHS8 MCS1 UMAG_03204 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 2005 cell wall organization [GO:0071555] GO:0003677; GO:0003774; GO:0004100; GO:0005524; GO:0005886; GO:0016021; GO:0016459; GO:0030659; GO:0071555 0 0 0 PF00173;PF08766;PF00063; Q4UMH6 CHOYP_LOC100369925.2.2 m.37303 sp Y381_RICFE 29.05 358 193 14 294 650 799 1096 1.02E-18 94.7 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q54KA7 CHOYP_AFUA_1G01020.22.50 m.32778 sp SECG_DICDI 40 280 167 1 3 281 204 483 1.02E-52 187 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q54KA7 CHOYP_SECG.2.3 m.39023 sp SECG_DICDI 40.183 219 130 1 1 218 291 509 1.02E-37 142 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q54XH6 CHOYP_LOC100640001.2.2 m.62667 sp PHYD1_DICDI 23.322 283 170 10 51 304 2 266 1.02E-08 59.3 PHYD1_DICDI reviewed Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog (EC 1.-.-.-) phyhd1 DDB_G0278961 Dictyostelium discoideum (Slime mold) 281 0 GO:0046872; GO:0051213 0 0 0 PF05721; Q5BKL8 CHOYP_XIAP.2.7 m.16335 sp XIAP_XENTR 23.707 232 146 6 287 489 262 491 1.02E-09 64.3 XIAP_XENTR reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 492 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of proteolysis [GO:0045861]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005737; GO:0007275; GO:0008270; GO:0016055; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0045861; GO:0090263; GO:1990001 0 0 0 PF00653; Q5RGJ6 CHOYP_CCD53.1.1 m.6684 sp CCD53_DANRE 54.404 193 76 4 1 191 1 183 1.02E-62 196 CCD53_DANRE reviewed WASH complex subunit CCDC53 (Coiled-coil domain-containing protein 53) ccdc53 Ch211-234f20.5 zgc:55718 Danio rerio (Zebrafish) (Brachydanio rerio) 200 0 GO:0071203 0 0 0 PF10152; Q5ZJN2 CHOYP_RB11A.1.2 m.26989 sp RB11A_CHICK 64.593 209 72 1 72 278 5 213 1.02E-94 281 RB11A_CHICK reviewed Ras-related protein Rab-11A RAB11A RCJMB04_16p4 Gallus gallus (Chicken) 216 astral microtubule organization [GO:0030953]; cytokinesis [GO:0000910]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of multivesicular body size [GO:0010796]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264] GO:0000910; GO:0000922; GO:0003924; GO:0005525; GO:0005739; GO:0005771; GO:0005802; GO:0005813; GO:0005828; GO:0005886; GO:0006887; GO:0007080; GO:0007264; GO:0010634; GO:0010796; GO:0010971; GO:0015031; GO:0030424; GO:0030953; GO:0031175; GO:0032154; GO:0032402; GO:0036258; GO:0043234; GO:0045335; GO:0045773; GO:0048471; GO:0055037; GO:0055038; GO:0060627; GO:0070062; GO:0072594; GO:0072659; GO:0090150; GO:0090307; GO:1990182 0 0 0 PF00071; Q62381 CHOYP_LOC100643173.1.2 m.15214 sp TLL1_MOUSE 24.515 567 315 29 48 548 363 882 1.02E-11 72 TLL1_MOUSE reviewed Tolloid-like protein 1 (mTll) (EC 3.4.24.-) Tll1 Tll Mus musculus (Mouse) 1013 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0004222; GO:0005509; GO:0005518; GO:0005576; GO:0007275; GO:0008270; GO:0030154 0 0 0 PF01400;PF00431; Q6AXJ7 CHOYP_F199X.1.1 m.10232 sp F199X_DANRE 30.387 362 174 12 23 316 22 373 1.02E-28 116 F199X_DANRE reviewed Protein FAM199X fam199x zgc:101060 Danio rerio (Zebrafish) (Brachydanio rerio) 374 0 0 0 0 0 PF15814; Q6DIB5 CHOYP_MEG10.24.91 m.33035 sp MEG10_MOUSE 40.506 316 160 16 2 310 277 571 1.02E-42 163 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q75WF2 CHOYP_DNS2A.2.2 m.63796 sp DNA2_ACAPL 37.748 302 163 8 8 291 64 358 1.02E-54 184 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q7PD79 CHOYP_GNAS.1.3 m.24858 sp GNAS_ANOGA 40.888 428 206 6 6 431 1 383 1.02E-109 331 GNAS_ANOGA reviewed Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) G-s-alpha-60A AGAP012095 Anopheles gambiae (African malaria mosquito) 383 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608] GO:0003924; GO:0004871; GO:0005525; GO:0007191; GO:0007606; GO:0007608; GO:0046872 0 0 0 PF00503; Q7TS72 CHOYP_LOC100878101.2.2 m.66854 sp IP3KC_MOUSE 44.382 178 91 2 31 204 406 579 1.02E-40 150 IP3KC_MOUSE reviewed "Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C)" Itpkc Mus musculus (Mouse) 678 mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005524; GO:0005654; GO:0005737; GO:0008440; GO:0098779; GO:0098792 0 0 0 PF03770; Q80VC6 CHOYP_PK1IP.1.1 m.49466 sp TSAP1_MOUSE 46.667 285 146 2 6 284 2 286 1.02E-85 261 TSAP1_MOUSE reviewed tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) Trnau1ap Secp43 Trspap1 Mus musculus (Mouse) 287 selenocysteine incorporation [GO:0001514] GO:0000166; GO:0001514; GO:0005634; GO:0005737; GO:0044822 0 0 0 PF00076; Q80X19 CHOYP_COEA1.2.2 m.48483 sp COEA1_MOUSE 35.263 190 116 4 69 255 1027 1212 1.02E-27 115 COEA1_MOUSE reviewed Collagen alpha-1(XIV) chain Col14a1 Mus musculus (Mouse) 1797 cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; homeostasis of number of cells within a tissue [GO:0048873]; regulation of cell growth involved in cardiac muscle cell development [GO:0061050]; ventricular cardiac muscle tissue development [GO:0003229] GO:0003229; GO:0005581; GO:0005614; GO:0005615; GO:0007155; GO:0030199; GO:0044822; GO:0048873; GO:0061050; GO:0070062 0 0 0 PF01391;PF00041;PF00092; Q86YT5 CHOYP_SLC13A5.1.1 m.2200 sp S13A5_HUMAN 47.475 198 99 1 1 193 361 558 1.02E-56 191 S13A5_HUMAN reviewed Solute carrier family 13 member 5 (Na(+)/citrate cotransporter) (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) SLC13A5 NACT Homo sapiens (Human) 568 citrate transport [GO:0015746]; tricarboxylic acid transmembrane transport [GO:0035674] GO:0005886; GO:0005887; GO:0015137; GO:0015141; GO:0015142; GO:0015746; GO:0017153; GO:0035674 0 0 0 PF00939; Q8AV28 CHOYP_LOC581113.2.2 m.57598 sp PCM1_CHICK 30.829 1158 607 40 697 1766 540 1591 1.02E-105 380 PCM1_CHICK reviewed Pericentriolar material 1 protein (PCM-1) PCM1 Gallus gallus (Chicken) 1904 centrosome organization [GO:0051297]; cilium assembly [GO:0042384]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; microtubule anchoring at centrosome [GO:0034454]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539] GO:0005813; GO:0005929; GO:0034451; GO:0034454; GO:0035735; GO:0042384; GO:0051297; GO:0071539; GO:0090316 0 0 0 PF15717; Q8BX09 CHOYP_RBBP5.1.1 m.40901 sp RBBP5_MOUSE 71.616 229 64 1 36 263 7 235 1.02E-121 360 RBBP5_MOUSE reviewed Retinoblastoma-binding protein 5 (RBBP-5) Rbbp5 Mus musculus (Mouse) 538 "cellular response to DNA damage stimulus [GO:0006974]; histone H3-K4 methylation [GO:0051568]; regulation of transcription, DNA-templated [GO:0006355]; response to estrogen [GO:0043627]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0006974; GO:0035064; GO:0035097; GO:0042800; GO:0043627; GO:0044212; GO:0044666; GO:0048188; GO:0051568; GO:0071339 0 0 0 PF00400; Q8C419 CHOYP_DWIL_GK24468.1.1 m.199 sp GP158_MOUSE 33.391 575 350 10 238 798 265 820 1.02E-96 330 GP158_MOUSE reviewed Probable G-protein coupled receptor 158 Gpr158 Kiaa1136 Mus musculus (Mouse) 1200 protein localization to plasma membrane [GO:0072659]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0004930; GO:0005886; GO:0008277; GO:0016020; GO:0016021; GO:0072659 0 0 0 PF00003; Q8HYN7 CHOYP_LOC100888051.1.3 m.1604 sp KCIP4_MACFA 59.701 201 72 2 16 216 59 250 1.02E-90 269 KCIP4_MACFA reviewed Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) KCNIP4 KCHIP4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 250 protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379] GO:0005244; GO:0005267; GO:0005509; GO:0005829; GO:0005886; GO:0008076; GO:0015459; GO:0072659; GO:1901379 0 0 0 PF13499;PF13833; Q8IDX6 CHOYP_ENS.2.3 m.28384 sp RBP2A_PLAF7 42.748 131 57 4 624 741 2740 2865 1.02E-09 67 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8IWZ3 CHOYP_AASI_1435.9.35 m.32954 sp ANKH1_HUMAN 31.942 479 271 21 749 1186 196 660 1.02E-33 145 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8IZL8 CHOYP_LOC100378410.1.1 m.18106 sp PELP1_HUMAN 28.08 552 364 13 66 589 88 634 1.02E-45 181 PELP1_HUMAN reviewed "Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)" PELP1 HMX3 MNAR Homo sapiens (Human) 1130 "cellular response to estrogen stimulus [GO:0071391]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006351; GO:0006364; GO:0008134; GO:0016020; GO:0035327; GO:0044822; GO:0045944; GO:0071339; GO:0071391 0 0 0 PF08166;PF08167; Q8JHV9 CHOYP_IAP2.2.5 m.16926 sp BIR7A_XENLA 31.507 292 159 7 75 361 139 394 1.02E-41 153 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8MSU3 CHOYP_AGAP_AGAP005170.1.2 m.9157 sp FRRS1_DROME 29.639 415 260 12 589 988 228 625 1.02E-50 193 FRRS1_DROME reviewed Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) CG8399 Drosophila melanogaster (Fruit fly) 647 oxidation-reduction process [GO:0055114] GO:0000293; GO:0016021; GO:0055114 0 0 cd08544; PF03188;PF03351;PF02014; Q8NEZ4 CHOYP_EDI_048910.1.2 m.31504 sp KMT2C_HUMAN 38.272 81 50 0 520 600 1638 1718 1.02E-10 70.1 KMT2C_HUMAN reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) 4911 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0008270; GO:0016746; GO:0018024; GO:0035097; GO:0042800; GO:0044666; GO:0044822 0 0 0 PF05965;PF05964;PF00628;PF00856; Q8NF91 CHOYP_DYST.2.2 m.66376 sp SYNE1_HUMAN 21.549 1007 751 12 104 1087 4119 5109 1.02E-45 184 SYNE1_HUMAN reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) 8797 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0006997; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q8VIK5 CHOYP_PEAR1.12.16 m.51059 sp PEAR1_MOUSE 30.623 369 214 19 173 517 438 788 1.02E-22 106 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q8WPA2 CHOYP_AR.1.1 m.38654 sp AR_BOMMO 45.21 334 172 4 25 356 36 360 1.02E-87 273 AR_BOMMO reviewed Allatostatin-A receptor (BAR) AR Bombyx mori (Silk moth) 361 0 GO:0004930; GO:0005886; GO:0016021; GO:0042562; GO:0042923 0 0 0 PF00001; Q8WZ42 CHOYP_LOC100891903.1.1 m.8349 sp TITIN_HUMAN 32.1 919 560 21 13 906 14713 15592 1.02E-112 385 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q90953 CHOYP_FBP1.5.7 m.40516 sp CSPG2_CHICK 37.113 194 114 6 10 199 3267 3456 1.02E-36 142 CSPG2_CHICK reviewed Versican core protein (Chondroitin sulfate proteoglycan core protein 2) (Chondroitin sulfate proteoglycan 2) (Large fibroblast proteoglycan) (PG-M) VCAN CSPG2 Gallus gallus (Chicken) 3562 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; Q92622 CHOYP_LOC100377422.1.2 m.54121 sp RUBIC_HUMAN 35.98 995 511 22 12 943 22 953 1.02E-178 546 RUBIC_HUMAN reviewed Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) RUBCN KIAA0226 Homo sapiens (Human) 972 autophagosome maturation [GO:0097352]; immune system process [GO:0002376]; multivesicular body sorting pathway [GO:0071985]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of autophagy [GO:0010507]; negative regulation of endocytosis [GO:0045806]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; phagocytosis [GO:0006909] GO:0002376; GO:0005654; GO:0005737; GO:0005764; GO:0005769; GO:0005770; GO:0006909; GO:0010507; GO:0043231; GO:0043553; GO:0045806; GO:0071985; GO:0097352; GO:1901097 0 0 0 PF02759;PF13901; Q96F81 CHOYP_LOC100372582.2.2 m.17399 sp DISP1_HUMAN 23.982 442 283 11 651 1086 751 1145 1.02E-23 112 DISP1_HUMAN reviewed Protein dispatched homolog 1 DISP1 DISPA Homo sapiens (Human) 1524 determination of left/right symmetry [GO:0007368]; diaphragm development [GO:0060539]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; patched ligand maturation [GO:0007225]; peptide transport [GO:0015833]; protein homotrimerization [GO:0070207]; regulation of protein secretion [GO:0050708]; smoothened signaling pathway [GO:0007224] GO:0007224; GO:0007225; GO:0007368; GO:0009880; GO:0009953; GO:0015197; GO:0015833; GO:0016021; GO:0016323; GO:0050708; GO:0060539; GO:0070207 0 0 0 PF02460; Q99JG7 CHOYP_BRAFLDRAFT_124675.1.1 m.61945 sp TNIP2_MOUSE 24.725 364 206 11 62 412 24 332 1.02E-14 80.1 TNIP2_MOUSE reviewed TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) Tnip2 Abin2 Mus musculus (Mouse) 430 "apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; cellular response to lipopolysaccharide [GO:0071222]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of B cell activation [GO:0050871]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage activation [GO:0043032]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein stabilization [GO:0050821]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 9 signaling pathway [GO:0034162]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006915; GO:0006954; GO:0007249; GO:0019901; GO:0023035; GO:0031593; GO:0034134; GO:0034138; GO:0034162; GO:0043032; GO:0043123; GO:0045944; GO:0046872; GO:0050821; GO:0050871; GO:0070498; GO:0071222; GO:2000352 0 0 0 PF16516;PF12180; Q9BXJ4 CHOYP_LOC100701854.4.6 m.30447 sp C1QT3_HUMAN 33.083 133 79 5 350 478 116 242 1.02E-08 59.3 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9ESN6 CHOYP_LOC100375148.1.2 m.20680 sp TRIM2_MOUSE 22.846 267 183 8 129 380 486 744 1.02E-08 60.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM3.19.58 m.32421 sp TRIM2_MOUSE 27.126 247 159 10 70 304 505 742 1.02E-13 75.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GLK0 CHOYP_TGM1.2.2 m.59718 sp TGM1_CANLF 36.454 705 402 16 167 868 123 784 1.02E-138 435 TGM1_CANLF reviewed Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) TGM1 Canis lupus familiaris (Dog) (Canis familiaris) 815 keratinization [GO:0031424]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838] GO:0003810; GO:0010838; GO:0016020; GO:0018149; GO:0031424; GO:0045787; GO:0046872 0 0 0 PF00927;PF01841;PF00868; Q9H1A3 CHOYP_METL9.1.1 m.13468 sp METL9_HUMAN 49.679 312 145 5 24 327 10 317 1.02E-103 309 METL9_HUMAN reviewed Methyltransferase-like protein 9 (DORA reverse strand protein) (DREV) (DREV1) METTL9 DREV CGI-81 Homo sapiens (Human) 318 0 0 0 0 0 PF05219; Q9H4K1 CHOYP_WDR11.2.2 m.58626 sp RIBC2_HUMAN 47.557 307 160 1 73 379 4 309 1.02E-83 260 RIBC2_HUMAN reviewed RIB43A-like with coiled-coils protein 2 RIBC2 C22orf11 Homo sapiens (Human) 309 0 GO:0005634 0 0 0 PF05914; Q9NUV9 CHOYP_GIMAP4.2.4 m.49005 sp GIMA4_HUMAN 39.597 298 165 5 5 296 22 310 1.02E-63 209 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9P2F6 CHOYP_PHUM_PHUM087190.1.1 m.13513 sp RHG20_HUMAN 27.094 203 141 2 27 224 363 563 1.02E-16 87 RHG20_HUMAN reviewed Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) 1191 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00788;PF00620; Q9R207 CHOYP_LOC578057.1.1 m.37028 sp NBN_MOUSE 31.871 433 282 6 12 442 1 422 1.02E-60 223 NBN_MOUSE reviewed Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1 homolog) Nbn Nbs1 Mus musculus (Mouse) 751 blastocyst growth [GO:0001832]; cell proliferation [GO:0008283]; DNA damage checkpoint [GO:0000077]; DNA duplex unwinding [GO:0032508]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; intrinsic apoptotic signaling pathway [GO:0097193]; in utero embryonic development [GO:0001701]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mitotic cell cycle checkpoint [GO:0007093]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of telomere capping [GO:1904354]; neuromuscular process controlling balance [GO:0050885]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; regulation of fibroblast proliferation [GO:0048145]; signal transduction in response to DNA damage [GO:0042770]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomeric 3' overhang formation [GO:0031860] GO:0000077; GO:0000723; GO:0000724; GO:0000784; GO:0001701; GO:0001832; GO:0003684; GO:0004003; GO:0005634; GO:0005657; GO:0005730; GO:0006302; GO:0007093; GO:0007095; GO:0008134; GO:0008283; GO:0016233; GO:0016605; GO:0030870; GO:0031860; GO:0031954; GO:0032206; GO:0032508; GO:0033674; GO:0035861; GO:0042405; GO:0042770; GO:0045190; GO:0047485; GO:0048145; GO:0050885; GO:0051321; GO:0097193; GO:1904354 0 0 0 PF00498;PF08599;PF16508; Q9UKK3 CHOYP_LOC100373327.11.13 m.52202 sp PARP4_HUMAN 41.924 291 166 3 18 306 925 1214 1.02E-64 246 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9UPV0 CHOYP_LOC100369167.1.1 m.31248 sp CE164_HUMAN 25.581 387 278 3 13 395 635 1015 1.02E-15 84.3 CE164_HUMAN reviewed Centrosomal protein of 164 kDa (Cep164) CEP164 KIAA1052 NPHP15 Homo sapiens (Human) 1460 cell division [GO:0051301]; cilium assembly [GO:0042384]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067] GO:0000086; GO:0005615; GO:0005654; GO:0005813; GO:0005814; GO:0005829; GO:0006281; GO:0007067; GO:0042384; GO:0051301; GO:0097539 0 0 0 0 Q9Y345 CHOYP_SC6A5.4.7 m.49048 sp SC6A5_HUMAN 53.412 337 141 4 5 325 191 527 1.02E-112 347 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y680 CHOYP_ISCW_ISCW002430.1.1 m.16083 sp FKBP7_HUMAN 42.708 96 53 1 27 122 166 259 1.02E-16 76.3 FKBP7_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase FKBP7 (PPIase FKBP7) (EC 5.2.1.8) (23 kDa FK506-binding protein) (23 kDa FKBP) (FKBP-23) (FK506-binding protein 7) (FKBP-7) (Rotamase) FKBP7 FKBP23 UNQ670/PRO1304 Homo sapiens (Human) 259 chaperone-mediated protein folding [GO:0061077] GO:0003755; GO:0005509; GO:0005528; GO:0005788; GO:0005789; GO:0061077 0 0 0 PF13499;PF00254; A0JM12 CHOYP_LOC579946.14.24 m.49258 sp MEG10_XENTR 40.437 183 96 8 185 366 571 741 1.03E-24 110 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A1BQQ5 CHOYP_MR30.1.2 m.23819 sp MR30_CONMR 37.77 278 153 11 28 296 23 289 1.03E-45 160 MR30_CONMR reviewed Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp isoform 1/2/3) (Mr30-1/2) 0 Conus marmoreus (Marble cone) 289 0 GO:0005576 0 0 0 PF00188; A2R345 CHOYP_HELF.1.1 m.65163 sp DCL21_ASPNC 25.357 560 351 17 879 1420 16 526 1.03E-29 132 DCL21_ASPNC reviewed Dicer-like protein 2-1 [Includes: Endoribonuclease dcl2-1 (EC 3.1.26.-); ATP-dependent helicase dcl2-1 (EC 3.6.4.-)] dcl2-1 An14g03000 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 1387 defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688]; RNA processing [GO:0006396] GO:0003723; GO:0004386; GO:0004525; GO:0005524; GO:0006396; GO:0046872; GO:0050688; GO:0051607 0 0 cd00593; PF00270;PF03368;PF00271;PF00636; A6H5Y1 CHOYP_MPHOSPH9.1.1 m.9795 sp MPP9_MOUSE 30.189 212 137 2 1076 1287 402 602 1.03E-21 106 MPP9_MOUSE reviewed M-phase phosphoprotein 9 Mphosph9 Mus musculus (Mouse) 991 0 GO:0000139; GO:0005737; GO:0005794; GO:0005813; GO:0005814; GO:0005886; GO:0016020 0 0 0 0 A6QPN6 CHOYP_BRAFLDRAFT_126371.2.3 m.44718 sp GILT_BOVIN 39.744 78 37 2 45 112 34 111 1.03E-10 59.7 GILT_BOVIN reviewed Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (IFI30 protein) IFI30 Bos taurus (Bovine) 244 antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590] GO:0005576; GO:0005764; GO:0016667; GO:0042590 0 0 0 PF03227; A7S3J7 CHOYP_LOC100209015.1.1 m.20859 sp RS3A_NEMVE 75.676 259 61 2 1 259 1 257 1.03E-131 375 RS3A_NEMVE reviewed 40S ribosomal protein S3a v1g242621 Nematostella vectensis (Starlet sea anemone) 263 translation [GO:0006412] GO:0003735; GO:0005829; GO:0006412; GO:0022627 0 0 0 PF01015; A7YY35 CHOYP_IFRX2.3.10 m.14857 sp K2012_BOVIN 36.22 254 156 3 1129 1377 891 1143 1.03E-24 116 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; D9HP19 CHOYP_BRAFLDRAFT_260946.2.2 m.61698 sp CNR3_MAIZE 36.19 105 58 2 4 99 31 135 1.03E-14 68.9 CNR3_MAIZE reviewed Cell number regulator 3 (ZmCNR03) CNR3 Zea mays (Maize) 167 0 GO:0016021 0 0 0 PF04749; H2A0L6 CHOYP_HEX.1.1 m.43068 sp HEX_PINMG 32.475 893 512 29 364 1219 5 843 1.03E-112 385 HEX_PINMG reviewed Putative beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) 0 Pinctada margaritifera (Black-lipped pearl oyster) 1135 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032] GO:0004563; GO:0005576; GO:0005975; GO:0006032; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. {ECO:0000250|UniProtKB:Q04786}. 0 0 PF03173;PF00728; O14522 CHOYP_PTPRC.2.14 m.5637 sp PTPRT_HUMAN 42.604 169 94 2 66 233 869 1035 1.03E-33 131 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O42449 CHOYP_IOD1.1.2 m.35888 sp IOD1_ORENI 53.846 117 54 0 1 117 130 246 1.03E-43 145 IOD1_ORENI reviewed Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) dio1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 248 hormone biosynthetic process [GO:0042446] GO:0004800; GO:0005789; GO:0016021; GO:0042446 0 0 0 PF00837; O43399 CHOYP_TPD52.1.1 m.35789 sp TPD54_HUMAN 43.22 118 67 0 50 167 55 172 1.03E-26 103 TPD54_HUMAN reviewed Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) 206 regulation of cell proliferation [GO:0042127] GO:0005737; GO:0042127; GO:0042803; GO:0044822; GO:0046982; GO:0048471 0 0 0 PF04201; O61199 CHOYP_NC73EF.1.1 m.44962 sp ODO1_CAEEL 46.207 145 51 4 41 158 51 195 1.03E-30 119 ODO1_CAEEL reviewed "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" ogdh-1 T22B11.5 Caenorhabditis elegans 1029 generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099] GO:0004591; GO:0005739; GO:0005759; GO:0006091; GO:0006096; GO:0006099; GO:0030976; GO:0031966; GO:0045252 0 0 0 PF16078;PF00676;PF16870;PF02779; O61462 CHOYP_RL37A.2.7 m.16856 sp RL37A_CRYST 86.957 92 12 0 25 116 1 92 1.03E-53 166 RL37A_CRYST reviewed 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) 92 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046872 0 0 0 PF01780; O70277 CHOYP_BRAFLDRAFT_69798.21.22 m.64631 sp TRIM3_RAT 23.841 151 111 2 6 152 593 743 1.03E-07 54.3 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88278 CHOYP_FAT4.5.10 m.25511 sp CELR3_RAT 26.939 735 457 29 1 699 314 1004 1.03E-43 174 CELR3_RAT reviewed Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Celsr3 Megf2 Rattus norvegicus (Rat) 3313 axonal fasciculation [GO:0007413]; cell surface receptor signaling pathway [GO:0007166]; cilium assembly [GO:0042384]; dopaminergic neuron axon guidance [GO:0036514]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of protein phosphorylation [GO:0001932]; serotonergic neuron axon guidance [GO:0036515] GO:0001764; GO:0001932; GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007166; GO:0007413; GO:0016021; GO:0032880; GO:0036514; GO:0036515; GO:0042384 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF02793;PF00053;PF02210; O95671 CHOYP_LOC100378818.1.2 m.12220 sp ASML_HUMAN 49.153 118 59 1 8 124 2 119 1.03E-29 115 ASML_HUMAN reviewed N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-) ASMTL Homo sapiens (Human) 621 0 GO:0005737; GO:0008171 0 0 cd00555; PF16864;PF02545;PF00891; P08836 CHOYP_BRAFLDRAFT_123202.1.1 m.17267 sp FPPS_CHICK 54.277 339 152 2 18 354 30 367 1.03E-131 383 FPPS_CHICK reviewed "Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)" FDPS Gallus gallus (Chicken) 367 cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384] GO:0004161; GO:0004337; GO:0005737; GO:0006695; GO:0033384; GO:0045337; GO:0046872 PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.; PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. 0 0 PF00348; P10079 CHOYP_LOC100633983.1.2 m.48319 sp FBP1_STRPU 40.796 201 109 5 18 217 704 895 1.03E-36 139 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P20585 CHOYP_BRAFLDRAFT_76550.2.21 m.4503 sp MSH3_HUMAN 41.096 146 83 1 2 144 450 595 1.03E-29 117 MSH3_HUMAN reviewed DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) MSH3 DUC1 DUG Homo sapiens (Human) 1137 DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; meiotic mismatch repair [GO:0000710]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; reciprocal meiotic recombination [GO:0007131] GO:0000228; GO:0000710; GO:0003684; GO:0005524; GO:0005654; GO:0006281; GO:0006298; GO:0007131; GO:0016020; GO:0019899; GO:0030983; GO:0032302; GO:0043570; GO:0045910; GO:0051096 0 0 0 PF01624;PF05188;PF05192;PF00488; P22031 CHOYP_BRAFLDRAFT_109205.3.5 m.21357 sp LEG_HELCR 41.111 90 50 2 47 133 13 102 1.03E-17 76.3 LEG_HELCR reviewed D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 105 0 GO:0005737; GO:0030246 0 0 0 PF02140; P26810 CHOYP_contig_006832 m.7797 sp POL_MLVF5 28.053 303 191 8 30 330 918 1195 1.03E-23 107 POL_MLVF5 reviewed Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Friend murine leukemia virus (isolate 57) (FrMLV) 1204 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003676; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00075;PF00665;PF00077;PF00078; P32251 CHOYP_contig_021301 m.24487 sp ADRA2_CARAU 29.286 140 95 3 38 174 30 168 1.03E-08 61.2 ADRA2_CARAU reviewed Alpha-2 adrenergic receptor (Alpha-2 adrenoreceptor) (Alpha-2 adrenoceptor) 0 Carassius auratus (Goldfish) 436 0 GO:0004935; GO:0005886; GO:0016021 0 0 0 PF00001; P42232 CHOYP_STAT-B.1.1 m.40654 sp STA5B_MOUSE 21.286 700 416 27 41 679 29 654 1.03E-20 102 STA5B_MOUSE reviewed Signal transducer and activator of transcription 5B Stat5b Mus musculus (Mouse) 786 2-oxoglutarate metabolic process [GO:0006103]; acute-phase response [GO:0006953]; allantoin metabolic process [GO:0000255]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hormone stimulus [GO:0032870]; citrate metabolic process [GO:0006101]; creatine metabolic process [GO:0006600]; creatinine metabolic process [GO:0046449]; cytokine-mediated signaling pathway [GO:0019221]; development of secondary female sexual characteristics [GO:0046543]; development of secondary male sexual characteristics [GO:0046544]; fatty acid metabolic process [GO:0006631]; female pregnancy [GO:0007565]; isoleucine metabolic process [GO:0006549]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; lactation [GO:0007595]; lipid storage [GO:0019915]; liver development [GO:0001889]; luteinization [GO:0001553]; mast cell migration [GO:0097531]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; oxaloacetate metabolic process [GO:0006107]; Peyer's patch development [GO:0048541]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cellular component movement [GO:0051272]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 biosynthetic process [GO:0045086]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; progesterone metabolic process [GO:0042448]; prolactin signaling pathway [GO:0038161]; regulation of cell adhesion [GO:0030155]; regulation of epithelial cell differentiation [GO:0030856]; regulation of multicellular organism growth [GO:0040014]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to lipopolysaccharide [GO:0032496]; sex differentiation [GO:0007548]; succinate metabolic process [GO:0006105]; taurine metabolic process [GO:0019530]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; valine metabolic process [GO:0006573] GO:0000255; GO:0000979; GO:0001077; GO:0001553; GO:0001666; GO:0001779; GO:0001889; GO:0003677; GO:0003682; GO:0004871; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006101; GO:0006103; GO:0006105; GO:0006107; GO:0006357; GO:0006549; GO:0006573; GO:0006600; GO:0006631; GO:0006953; GO:0007259; GO:0007548; GO:0007565; GO:0007595; GO:0008284; GO:0019218; GO:0019221; GO:0019530; GO:0019903; GO:0019915; GO:0030155; GO:0030856; GO:0032355; GO:0032496; GO:0032819; GO:0032825; GO:0032870; GO:0033077; GO:0035259; GO:0038161; GO:0040014; GO:0040018; GO:0042104; GO:0042448; GO:0043029; GO:0043066; GO:0045086; GO:0045471; GO:0045579; GO:0045588; GO:0045621; GO:0045647; GO:0045648; GO:0045931; GO:0045944; GO:0045954; GO:0046449; GO:0046543; GO:0046544; GO:0046983; GO:0048541; GO:0048661; GO:0050729; GO:0051272; GO:0060397; GO:0070669; GO:0070670; GO:0070672; GO:0071363; GO:0071364; GO:0097531 0 0 0 PF00017;PF01017;PF02864;PF02865; P42578 CHOYP_FRIY.1.1 m.5052 sp FRIY_LYMST 48.165 218 103 4 4 216 9 221 1.03E-58 188 FRIY_LYMST reviewed Yolk ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 239 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005576; GO:0005623; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P43487 CHOYP_BRAFLDRAFT_272416.1.1 m.56641 sp RANG_HUMAN 74.074 135 35 0 16 150 27 161 1.03E-67 209 RANG_HUMAN reviewed Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) RANBP1 Homo sapiens (Human) 201 G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of mitotic centrosome separation [GO:0046604]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]; signal transduction [GO:0007165]; spindle organization [GO:0007051]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032] GO:0000082; GO:0005092; GO:0005096; GO:0005634; GO:0005635; GO:0005737; GO:0005813; GO:0005913; GO:0006405; GO:0006511; GO:0006606; GO:0007051; GO:0007165; GO:0008536; GO:0016032; GO:0046604; GO:0098641 0 0 0 PF00638; P45842 CHOYP_LOC100369402.2.2 m.29002 sp RL34_AEDAL 72.381 105 28 1 19 123 3 106 1.03E-45 147 RL34_AEDAL reviewed 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01199; P47758 CHOYP_LOC100373590.1.1 m.51920 sp SRPRB_MOUSE 46.188 223 108 6 39 256 54 269 1.03E-59 192 SRPRB_MOUSE reviewed Signal recognition particle receptor subunit beta (SR-beta) Srprb Mus musculus (Mouse) 269 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0005789; GO:0005881; GO:0007264; GO:0016020; GO:0016021 0 0 0 PF09439; P52486 CHOYP_LOC726145.1.1 m.27163 sp UBCD4_DROME 72.864 199 54 0 1 199 1 199 1.03E-101 295 UBCD4_DROME reviewed Ubiquitin-conjugating enzyme E2-22 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) Ubc4 UbcD4 CG8284 Drosophila melanogaster (Fruit fly) 199 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726] GO:0000209; GO:0004842; GO:0005524; GO:0005634; GO:0005737; GO:0031625; GO:0043161; GO:0051726; GO:0061630; GO:0070628 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00627;PF00179; P58197 CHOYP_TCFAP2B.1.2 m.10178 sp AP2A_RAT 66.667 219 71 2 206 424 197 413 1.03E-97 302 AP2A_RAT reviewed Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) Tfap2a Tcfap2a Rattus norvegicus (Rat) 437 "bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; eyelid development in camera-type eye [GO:0061029]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; negative regulation of apoptotic process [GO:0043066]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; palate development [GO:0060021]; positive regulation of bone mineralization [GO:0030501]; positive regulation of gene expression [GO:0010628]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell proliferation [GO:0042127]; response to lipopolysaccharide [GO:0032496]; response to organic substance [GO:0010033]; response to water deprivation [GO:0009414]; Schwann cell development [GO:0014044]; sensory perception of sound [GO:0007605]; trigeminal nerve development [GO:0021559]" GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0000982; GO:0001077; GO:0001078; GO:0001822; GO:0003404; GO:0003409; GO:0003682; GO:0003713; GO:0005634; GO:0005829; GO:0007605; GO:0008134; GO:0009414; GO:0010033; GO:0010628; GO:0010944; GO:0014044; GO:0021559; GO:0021623; GO:0030501; GO:0032496; GO:0035115; GO:0042127; GO:0042472; GO:0043066; GO:0043565; GO:0044212; GO:0045893; GO:0045944; GO:0048701; GO:0060021; GO:0060349; GO:0061029; GO:0070172; GO:0071281; GO:2000378 0 0 0 PF03299; P80193 CHOYP_TRIADDRAFT_61286.1.1 m.26704 sp BODG_PSESK 32.075 371 231 5 103 463 22 381 1.03E-60 206 BODG_PSESK reviewed "Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)" 0 Pseudomonas sp. (strain AK-1) 383 carnitine biosynthetic process [GO:0045329] GO:0005506; GO:0005737; GO:0008336; GO:0045329 PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis. 0 0 PF06155;PF02668; P82596 CHOYP_LOC100371822.1.2 m.6098 sp PLC_HALLA 36.364 132 81 3 18 149 2 130 1.03E-21 88.6 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; P82861 CHOYP_BRAFLDRAFT_88012.1.1 m.12815 sp ADRO_SALFO 52.459 488 222 7 1 483 16 498 1.03E-176 508 ADRO_SALFO reviewed "NADPH:adrenodoxin oxidoreductase, mitochondrial (AR) (Adrenodoxin reductase) (EC 1.18.1.6) (Ferredoxin--NADP(+) reductase) (Ferredoxin reductase)" fdxr Salvelinus fontinalis (Brook trout) (Salmo fontinalis) 498 cholesterol metabolic process [GO:0008203] GO:0005759; GO:0008203; GO:0015039 PATHWAY: Steroid metabolism; cholesterol metabolism. 0 0 PF07992; P86854 CHOYP_PLCL.2.8 m.56031 sp PLCL_MYTGA 35.135 148 83 7 6 143 3 147 1.03E-23 93.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P90789 CHOYP_NDUFB7.1.1 m.27222 sp NDUB7_CAEEL 42.857 105 57 2 42 144 15 118 1.03E-19 82.4 NDUB7_CAEEL reviewed NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 D2030.4 Caenorhabditis elegans 123 0 GO:0005743; GO:0005758; GO:0008137; GO:0070469 0 0 0 PF05676; Q02357 CHOYP_LOC100197555.6.7 m.62732 sp ANK1_MOUSE 29.921 254 147 8 455 704 135 361 1.03E-20 101 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q06396 CHOYP_LOC100637317.2.4 m.25543 sp ARF1_ORYSJ 59.116 181 70 2 1 181 1 177 1.03E-76 230 ARF1_ORYSJ reviewed ADP-ribosylation factor 1 (13 kDa cold-induced protein) Os01g0813400 LOC_Os01g59790 OsJ_03844 OSJNBa0085D07.10 P0425G02.41 P0432B10.14 Oryza sativa subsp. japonica (Rice) 181 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q06852 CHOYP_contig_005204 m.5936 sp SLAP1_CLOTH 30.508 413 248 10 218 618 1414 1799 1.03E-09 65.9 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0VGY8 CHOYP_AFUA_1G01020.16.50 m.23837 sp TANC1_MOUSE 39.264 163 99 0 2 164 1086 1248 1.03E-28 114 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q13263 CHOYP_LOC100370588.6.19 m.21265 sp TIF1B_HUMAN 25.871 201 131 9 1 190 135 328 1.03E-07 55.5 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q13492 CHOYP_FGFR2.3.3 m.59531 sp PICAL_HUMAN 34.521 449 196 17 1 387 225 637 1.03E-54 195 PICAL_HUMAN reviewed Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) PICALM CALM Homo sapiens (Human) 652 "cargo loading into vesicle [GO:0035459]; cell proliferation [GO:0008283]; clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; endosomal transport [GO:0016197]; iron ion homeostasis [GO:0055072]; iron ion import into cell [GO:0097459]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of beta-amyloid formation [GO:1902004]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription, DNA-templated [GO:0045893]; protein complex assembly [GO:0006461]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; synaptic vesicle maturation [GO:0016188]; vesicle-mediated transport [GO:0016192]" GO:0005545; GO:0005634; GO:0005794; GO:0005905; GO:0005913; GO:0006461; GO:0006898; GO:0008283; GO:0010629; GO:0016020; GO:0016188; GO:0016192; GO:0016197; GO:0030100; GO:0030136; GO:0030276; GO:0031623; GO:0031982; GO:0032050; GO:0032880; GO:0035459; GO:0035615; GO:0042734; GO:0043025; GO:0045211; GO:0045893; GO:0048261; GO:0048268; GO:0055072; GO:0072583; GO:0097418; GO:0097459; GO:0098641; GO:1901216; GO:1902004; GO:1902959; GO:1902961; GO:1902963 0 0 0 PF07651; Q15526 CHOYP_SURF1.1.2 m.8264 sp SURF1_HUMAN 40.562 249 138 4 62 305 46 289 1.03E-57 191 SURF1_HUMAN reviewed Surfeit locus protein 1 SURF1 SURF-1 Homo sapiens (Human) 300 aerobic respiration [GO:0009060]; ATP biosynthetic process [GO:0006754]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; oxidation-reduction process [GO:0055114]; oxidative phosphorylation [GO:0006119]; respiratory chain complex IV assembly [GO:0008535] GO:0004129; GO:0005746; GO:0006119; GO:0006754; GO:0008535; GO:0009060; GO:0016021; GO:0033617; GO:0055114 0 0 cd06662; PF02104; Q3B756 CHOYP_ZEB2.1.1 m.29737 sp FUZZY_RAT 53.061 98 46 0 21 118 38 135 1.03E-31 118 FUZZY_RAT reviewed Protein fuzzy homolog Fuz Rattus norvegicus (Rat) 415 cilium assembly [GO:0042384]; embryonic body morphogenesis [GO:0010172]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of planar polarity [GO:0001736]; hair follicle development [GO:0001942]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [GO:2000314]; negative regulation of neural crest formation [GO:0090301]; neural tube closure [GO:0001843]; nonmotile primary cilium assembly [GO:0035058]; positive regulation of cilium assembly [GO:0045724]; protein transport [GO:0015031]; regulation of smoothened signaling pathway [GO:0008589] GO:0001736; GO:0001843; GO:0001942; GO:0005737; GO:0005856; GO:0008285; GO:0008589; GO:0010172; GO:0015031; GO:0030336; GO:0035058; GO:0042384; GO:0045724; GO:0048704; GO:0070062; GO:0090090; GO:0090301; GO:2000314 0 0 0 0 Q3TI53 CHOYP_LOC100061302.1.1 m.47173 sp SCHI1_MOUSE 38.662 269 118 8 325 556 217 475 1.03E-37 148 SCHI1_MOUSE reviewed Schwannomin-interacting protein 1 (SCHIP-1) Schip1 Mus musculus (Mouse) 484 estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; luteinization [GO:0001553]; nitrogen compound metabolic process [GO:0006807]; palate development [GO:0060021]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745] GO:0001553; GO:0001822; GO:0005737; GO:0006807; GO:0008210; GO:0008585; GO:0009791; GO:0010761; GO:0042802; GO:0042803; GO:0048008; GO:0048705; GO:0048745; GO:0060021; GO:0060325 0 0 0 PF10148; Q3TNH5 CHOYP_F172A.1.2 m.518 sp F172A_MOUSE 62.987 154 55 2 27 178 49 202 1.03E-58 192 F172A_MOUSE reviewed Protein FAM172A Fam172a Mus musculus (Mouse) 417 0 GO:0005576; GO:0005783 0 0 0 PF09757; Q498S6 CHOYP_ZCCHC14.1.1 m.50192 sp ZCHC2_RAT 26.349 315 145 9 8 239 94 404 1.03E-17 92.4 ZCHC2_RAT reviewed Zinc finger CCHC domain-containing protein 2 Zcchc2 Rattus norvegicus (Rat) 1168 0 GO:0003676; GO:0008270; GO:0035091 0 0 0 PF00098; Q4V7E8 CHOYP_LRRF2.1.2 m.37474 sp LRRF2_RAT 58.333 108 44 1 10 116 329 436 1.03E-31 118 LRRF2_RAT reviewed Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) Lrrfip2 Rattus norvegicus (Rat) 437 "regulation of transcription, DNA-templated [GO:0006355]; Wnt signaling pathway [GO:0016055]" GO:0006355; GO:0016055 0 0 0 PF09738; Q4VBV9 CHOYP_LOC100017224.1.1 m.26828 sp NIT2_DANRE 46.35 274 143 3 3 276 2 271 1.03E-86 263 NIT2_DANRE reviewed Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2) nit2 zgc:109720 Danio rerio (Zebrafish) (Brachydanio rerio) 277 nitrogen compound metabolic process [GO:0006807] GO:0005737; GO:0006807; GO:0050152 0 0 0 PF00795; Q4ZJM7 CHOYP_COPA1.1.2 m.61558 sp OTOL1_MOUSE 44.928 207 95 4 115 305 105 308 1.03E-26 113 OTOL1_MOUSE reviewed Otolin-1 Otol1 Gm414 Mus musculus (Mouse) 482 0 GO:0005576; GO:0005581 0 0 0 PF00386;PF01391; Q4ZJM9 CHOYP_contig_053453 m.64044 sp C1QL4_MOUSE 34.343 99 61 2 5 101 118 214 1.03E-07 51.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q502K3 CHOYP_LOC753665.1.2 m.9438 sp ANR52_DANRE 31.461 178 121 1 10 187 108 284 1.03E-17 86.7 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q56R14 CHOYP_LOC100372618.1.1 m.10541 sp TRI33_XENLA 28.188 149 104 2 8 156 178 323 1.03E-08 61.2 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5BJS9 CHOYP_MORN4.1.1 m.5930 sp MORN4_RAT 59.504 121 46 1 2 119 15 135 1.03E-44 145 MORN4_RAT reviewed MORN repeat-containing protein 4 Morn4 Rattus norvegicus (Rat) 146 0 0 0 0 0 PF02493; Q5ND56 CHOYP_FA57B.2.3 m.45142 sp FA57A_MOUSE 40.553 217 125 3 44 259 35 248 1.03E-49 167 FA57A_MOUSE reviewed Protein FAM57A Fam57a Mus musculus (Mouse) 257 0 GO:0005886; GO:0016021 0 0 0 PF03798; Q5R655 CHOYP_LOC100373791.1.1 m.53882 sp PTCD1_PONAB 24.555 562 388 10 77 628 57 592 1.03E-41 165 PTCD1_PONAB reviewed "Pentatricopeptide repeat-containing protein 1, mitochondrial" PTCD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 698 tRNA 3'-end processing [GO:0042780] GO:0000049; GO:0005759; GO:0042780 0 0 0 PF13812;PF17177; Q5RF84 CHOYP_UB2G2.1.1 m.7534 sp UB2G2_PONAB 83.636 165 27 0 1 165 1 165 1.03E-103 297 UB2G2_PONAB reviewed Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2) UBE2G2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 165 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein K48-linked ubiquitination [GO:0070936]; protein N-linked glycosylation via asparagine [GO:0018279] GO:0004842; GO:0005524; GO:0018279; GO:0030433; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q5SZD4 CHOYP_RL18A.1.8 m.12899 sp GLYL3_HUMAN 21.03 233 163 6 13 231 13 238 1.03E-08 58.5 GLYL3_HUMAN reviewed Glycine N-acyltransferase-like protein 3 (EC 2.3.1.-) GLYATL3 C6orf140 Homo sapiens (Human) 288 0 GO:0005739; GO:0047961 0 0 0 PF08444;PF06021; Q5ZIZ2 CHOYP_BRAFLDRAFT_74594.3.3 m.1992 sp SMYD5_CHICK 26.396 394 223 18 318 680 39 396 1.03E-17 89.7 SMYD5_CHICK reviewed SET and MYND domain-containing protein 5 (EC 2.1.1.-) SMYD5 RCJMB04_22j23 Gallus gallus (Chicken) 420 0 GO:0008168; GO:0046872 0 0 0 PF00856; Q6PGL7 CHOYP_BRAFLDRAFT_118099.1.6 m.1356 sp FAM21_MOUSE 32.576 1188 555 42 30 1123 18 1053 1.03E-90 326 FAM21_MOUSE reviewed WASH complex subunit FAM21 Fam21 D6Wsu116e Kiaa0592 Mus musculus (Mouse) 1334 "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005546; GO:0005547; GO:0005730; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005886; GO:0010314; GO:0015031; GO:0031901; GO:0032266; GO:0042147; GO:0043231; GO:0043325; GO:0070273; GO:0071203; GO:0080025 0 0 0 PF15255; Q6ZR37 CHOYP_LOC100908993.1.1 m.40099 sp PKHG7_HUMAN 35.876 354 218 5 564 910 3 354 1.03E-59 212 PKHG7_HUMAN reviewed Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 Homo sapiens (Human) 379 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF00621; Q75N73 CHOYP_S39AE.1.3 m.4080 sp S39AE_MOUSE 36.402 478 223 12 34 454 35 488 1.03E-83 268 S39AE_MOUSE reviewed Zinc transporter ZIP14 (Factor for adipocyte differentiation 123) (FAD-123) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) Slc39a14 Fad123 Kiaa0062 Zip14 Mus musculus (Mouse) 489 cellular zinc ion homeostasis [GO:0006882]; iron ion transport [GO:0006826]; zinc II ion transmembrane import [GO:0071578]; zinc II ion transmembrane transport [GO:0071577]; zinc II ion transport [GO:0006829] GO:0005385; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0006826; GO:0006829; GO:0006882; GO:0015093; GO:0016021; GO:0071577; GO:0071578 0 0 0 PF02535; Q80V70 CHOYP_BRAFLDRAFT_224574.6.18 m.24299 sp MEGF6_MOUSE 38.344 326 185 10 5 328 666 977 1.03E-43 164 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q80VJ3 CHOYP_DNPH1.1.1 m.28418 sp DNPH1_MOUSE 57.971 138 57 1 36 172 11 148 1.03E-51 166 DNPH1_MOUSE reviewed 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 (EC 3.2.2.-) (c-Myc-responsive protein Rcl) Dnph1 Rcl Mus musculus (Mouse) 173 deoxyribonucleoside monophosphate catabolic process [GO:0009159]; epithelial cell differentiation [GO:0030855]; nucleoside metabolic process [GO:0009116]; nucleotide metabolic process [GO:0009117]; positive regulation of cell growth [GO:0030307] GO:0005634; GO:0005737; GO:0009116; GO:0009117; GO:0009159; GO:0030307; GO:0030855; GO:0050144; GO:0070062; GO:0070694 0 0 0 PF05014; Q86Y13 CHOYP_LOC100167996.1.1 m.51081 sp DZIP3_HUMAN 33.696 92 54 2 62 146 451 542 1.03E-06 55.8 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8AXV0 CHOYP_ISCW_ISCW008555.1.1 m.40873 sp SH3G1_CHICK 51.206 373 156 3 33 385 1 367 1.03E-132 387 SH3G1_CHICK reviewed Endophilin-A2 (Endophilin-2) (SH3 domain-containing GRB2-like protein 2) (SH3p8) SH3GL1 SH3P8 Gallus gallus (Chicken) 367 endocytosis [GO:0006897] GO:0002102; GO:0006897; GO:0008289; GO:0030054; GO:0031901; GO:0042995 0 0 0 PF03114;PF00018; Q8C3K5 CHOYP_LOC100371365.1.2 m.55767 sp TMM72_MOUSE 28.244 131 91 2 19 147 14 143 1.03E-11 65.1 TMM72_MOUSE reviewed Transmembrane protein 72 Tmem72 Mus musculus (Mouse) 275 0 GO:0016021 0 0 0 PF16054; Q8C4U2 CHOYP_LOC100741204.1.1 m.28420 sp TM145_MOUSE 30.147 136 87 4 25 155 32 164 1.03E-14 80.9 TM145_MOUSE reviewed Transmembrane protein 145 Tmem145 Mus musculus (Mouse) 746 G-protein coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] GO:0007186; GO:0016021; GO:0019236 0 0 0 PF10192; Q8K4C0 CHOYP_BRAFLDRAFT_113828.1.2 m.8440 sp FMO5_RAT 42.351 536 294 7 3 532 4 530 1.03E-151 448 FMO5_RAT reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) Fmo5 Rattus norvegicus (Rat) 533 drug metabolic process [GO:0017144] GO:0004499; GO:0005789; GO:0016021; GO:0017144; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; Q8MJ06 CHOYP_LOC100175334.2.2 m.66171 sp RP1_PAPHA 35.885 209 114 4 88 296 40 228 1.03E-29 122 RP1_PAPHA reviewed Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein homolog) RP1 Papio hamadryas (Hamadryas baboon) 2152 axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601] GO:0001750; GO:0001917; GO:0005737; GO:0005875; GO:0007601; GO:0008017; GO:0035082; GO:0035556; GO:0035845; GO:0042461; GO:0045494; GO:0046548; GO:0046549 0 0 cd01617; PF03607; Q8R4H2 CHOYP_ISCW_ISCW023722.1.1 m.25472 sp ARHGC_MOUSE 29.143 525 231 18 137 620 67 491 1.03E-38 159 ARHGC_MOUSE reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) Arhgef12 Kiaa0382 Larg Mus musculus (Mouse) 1543 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; regulation of Rho protein signal transduction [GO:0035023] GO:0001664; GO:0005089; GO:0005096; GO:0005737; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q90835 CHOYP_LOC101482309.1.1 m.35845 sp EF1A_CHICK 48.718 78 39 1 30 107 385 461 1.03E-14 72.8 EF1A_CHICK reviewed Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) EEF1A Gallus gallus (Chicken) 462 cellular response to epidermal growth factor stimulus [GO:0071364] GO:0000049; GO:0003746; GO:0003924; GO:0005525; GO:0005615; GO:0005622; GO:0005730; GO:0005829; GO:0030864; GO:0032587; GO:0043209; GO:0044822; GO:0070062; GO:0071364 0 0 0 PF03144;PF03143; Q921R4 CHOYP_LOC100114549.1.1 m.65626 sp DJC14_MOUSE 41.393 244 130 5 530 766 426 663 1.03E-49 190 DJC14_MOUSE reviewed DnaJ homolog subfamily C member 14 Dnajc14 Mus musculus (Mouse) 703 protein transport [GO:0015031] GO:0005654; GO:0005730; GO:0005789; GO:0015031; GO:0016020; GO:0016021; GO:0070062 0 0 cd06257; PF00226;PF14901; Q95LU3 CHOYP_BRAFLDRAFT_86061.4.13 m.29678 sp FBCD1_MACFA 44.444 225 113 5 74 289 209 430 1.03E-58 196 FBCD1_MACFA reviewed Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 431 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q96LQ0 CHOYP_ISCW_ISCW014880.1.1 m.27978 sp PPR36_HUMAN 30.526 380 216 9 20 380 30 380 1.03E-47 171 PPR36_HUMAN reviewed Protein phosphatase 1 regulatory subunit 36 PPP1R36 C14orf50 Homo sapiens (Human) 422 negative regulation of phosphatase activity [GO:0010923] GO:0004864; GO:0010923; GO:0019902 0 0 0 PF14895; Q96M20 CHOYP_LOC100893228.4.5 m.45934 sp CNBD2_HUMAN 24.299 214 149 4 228 433 87 295 1.03E-07 58.5 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q99M80 CHOYP_PTPRK.12.20 m.39554 sp PTPRT_MOUSE 30.283 743 464 17 385 1093 731 1453 1.03E-86 311 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99M80 CHOYP_PTPRT.1.45 m.2628 sp PTPRT_MOUSE 32.198 587 364 13 403 973 738 1306 1.03E-77 283 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99N28 CHOYP_RL8.8.10 m.59038 sp CADM3_MOUSE 26.754 228 143 10 80 292 86 304 1.03E-11 70.1 CADM3_MOUSE reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (TSLC1-like protein 1) Cadm3 Igsf4b Necl1 Syncam3 Tsll1 Mus musculus (Mouse) 396 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein localization [GO:0008104] GO:0004872; GO:0005102; GO:0005887; GO:0005911; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0008104; GO:0042803; GO:0050839 0 0 0 PF08205;PF07679; Q99NH0 CHOYP_LOC583072.13.25 m.47279 sp ANR17_MOUSE 34.843 287 177 7 1 279 405 689 1.03E-37 146 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BX66 CHOYP_LOC100867381.6.8 m.44771 sp SRBS1_HUMAN 31.4 707 320 28 979 1583 286 929 1.03E-57 224 SRBS1_HUMAN reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) 1292 cell-matrix adhesion [GO:0007160]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; muscle contraction [GO:0006936]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0003779; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005913; GO:0005915; GO:0005924; GO:0005925; GO:0006936; GO:0007160; GO:0008092; GO:0008286; GO:0015758; GO:0016363; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q9CQX8 CHOYP_LOC101157864.1.2 m.9913 sp RT36_MOUSE 39.216 102 44 4 21 108 5 102 1.03E-10 57 RT36_MOUSE reviewed "28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt)" Mrps36 Mus musculus (Mouse) 102 2-oxoglutarate metabolic process [GO:0006103]; oxidation-reduction process [GO:0055114] GO:0005739; GO:0005763; GO:0006103; GO:0009353; GO:0055114 0 0 0 PF10937; Q9DAM1 CHOYP_LOC100374522.1.1 m.66943 sp LRC34_MOUSE 45.75 400 211 3 10 408 7 401 1.03E-124 370 LRC34_MOUSE reviewed Leucine-rich repeat-containing protein 34 Lrrc34 Mus musculus (Mouse) 415 0 0 0 0 0 PF13516; Q9DFQ7 CHOYP_BRAFLDRAFT_273508.3.4 m.19752 sp RL24_GILMI 76.613 124 29 0 1 124 1 124 1.03E-66 202 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9H777 CHOYP_RNZ1.1.1 m.29553 sp RNZ1_HUMAN 48.209 363 179 5 41 396 2 362 1.03E-105 321 RNZ1_HUMAN reviewed Zinc phosphodiesterase ELAC protein 1 (EC 3.1.26.11) (Deleted in Ma29) (ElaC homolog protein 1) (Ribonuclease Z 1) (RNase Z 1) (tRNA 3 endonuclease 1) (tRNase Z 1) ELAC1 D29 Homo sapiens (Human) 363 0 GO:0005634; GO:0005829; GO:0042781; GO:0046872 0 0 0 PF00753;PF12706; Q9HC56 CHOYP_PCDH7.2.3 m.11481 sp PCDH9_HUMAN 32.461 764 490 16 11 756 6 761 1.03E-109 372 PCDH9_HUMAN reviewed Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0030426; GO:0030900; GO:0044291 0 0 0 PF00028;PF08266;PF08374; Q9JID1 CHOYP_MMSA.2.2 m.16272 sp PDCD4_RAT 49.398 415 195 5 40 444 56 465 1.03E-116 352 PDCD4_RAT reviewed Programmed cell death protein 4 (Death up-regulated gene protein) Pdcd4 Dug Rattus norvegicus (Rat) 469 "apoptotic process [GO:0006915]; cell aging [GO:0007569]; negative regulation of apoptotic process [GO:0043066]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; regulation of protein metabolic process [GO:0051246]" GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006915; GO:0007569; GO:0034393; GO:0043066; GO:0043508; GO:0045892; GO:0051246; GO:1904761 0 0 0 PF02847; Q9LGZ2 CHOYP_LOC100183535.2.2 m.10350 sp LCYD1_ORYSJ 29.787 423 256 12 9 398 49 463 1.03E-46 169 LCYD1_ORYSJ reviewed Putative L-cysteine desulfhydrase 1 (EC 4.4.1.28) (OsL-CDes1) (L-CDes1) Os01g0290100 LOC_Os01g18640 P0469E05.28 Oryza sativa subsp. japonica (Rice) 482 0 GO:0016829 0 0 0 PF00266; Q9NZJ4 CHOYP_SACS.4.17 m.32398 sp SACS_HUMAN 24.556 2871 1759 98 1092 3718 1866 4573 1.03E-169 597 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9QYF1 CHOYP_LOC100557184.1.1 m.30334 sp RDH11_MOUSE 44.286 280 151 2 34 313 32 306 1.03E-70 224 RDH11_MOUSE reviewed Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Cell line MC/9.IL4-derived protein 1) (M42C60) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short-chain aldehyde dehydrogenase) (SCALD) Rdh11 Arsdr1 Mdt1 Psdr1 Mus musculus (Mouse) 316 adaptation of rhodopsin mediated signaling [GO:0016062]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572] GO:0001917; GO:0004745; GO:0005622; GO:0005789; GO:0016021; GO:0016062; GO:0042572; GO:0042574; GO:0052650 0 0 0 PF00106; Q9QZ11 CHOYP_EXO1.1.2 m.16958 sp EXO1_MOUSE 43.089 246 107 10 1 221 218 455 1.03E-42 168 EXO1_MOUSE reviewed Exonuclease 1 (mExo1) (EC 3.1.-.-) (Exonuclease I) Exo1 Mus musculus (Mouse) 837 DNA recombination [GO:0006310]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; isotype switching [GO:0045190]; meiotic cell cycle [GO:0051321]; mismatch repair [GO:0006298]; nucleobase-containing compound metabolic process [GO:0006139]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0002455; GO:0003677; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006139; GO:0006298; GO:0006310; GO:0008409; GO:0016446; GO:0035312; GO:0045145; GO:0045190; GO:0046872; GO:0048256; GO:0051321; GO:0051908 0 0 0 PF00867;PF00752; Q9TUI8 CHOYP_LOC100712443.1.1 m.47291 sp FAAH1_PIG 43.529 510 274 9 73 578 71 570 1.03E-115 358 FAAH1_PIG reviewed Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Oleamide hydrolase 1) FAAH FAAH1 Sus scrofa (Pig) 579 fatty acid catabolic process [GO:0009062] GO:0000139; GO:0005789; GO:0009062; GO:0016021; GO:0016884; GO:0017064; GO:0031090; GO:0103073 0 0 0 PF01425; Q9TWL9 CHOYP_LOC100205674.1.1 m.5810 sp COMA_CONMA 38.462 52 32 0 33 84 14 65 1.03E-06 46.6 COMA_CONMA reviewed Conodipine-M alpha chain (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) 0 Conus magus (Magus cone) (Magician's cone snail) 77 lipid catabolic process [GO:0016042] GO:0004623; GO:0005576; GO:0016042 0 0 0 0 Q9UBQ7 CHOYP_LOC100375265.2.2 m.11396 sp GRHPR_HUMAN 58.204 323 132 2 31 350 5 327 1.03E-131 382 GRHPR_HUMAN reviewed Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) 328 dicarboxylic acid metabolic process [GO:0043648]; excretion [GO:0007588]; glyoxylate metabolic process [GO:0046487]; metabolic process [GO:0008152]; oxidation-reduction process [GO:0055114]; protein oligomerization [GO:0051259] GO:0005737; GO:0005782; GO:0005829; GO:0007588; GO:0008152; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051259; GO:0051287; GO:0055114; GO:0070062; GO:0070402 0 0 0 PF00389;PF02826; Q9V895 CHOYP_LOC100372942.1.1 m.31119 sp AN32A_DROME 60 170 65 1 5 174 1 167 1.03E-63 203 AN32A_DROME reviewed Acidic leucine-rich nuclear phosphoprotein 32 family member A Anp32a Mapmodulin CG5784 Drosophila melanogaster (Fruit fly) 261 microtubule-based process [GO:0007017]; nucleocytoplasmic transport [GO:0006913] GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005875; GO:0006913; GO:0007017; GO:0008017; GO:0048471 0 0 0 0 Q9XZ71 CHOYP_AGAP_AGAP002350.1.1 m.37286 sp TNNT_PERAM 39.63 270 141 8 35 300 48 299 1.03E-31 124 TNNT_PERAM reviewed Troponin T (TnT) TNT Periplaneta americana (American cockroach) (Blatta americana) 384 regulation of muscle contraction [GO:0006937] GO:0005861; GO:0006937 0 0 0 PF00992; Q9Y248 CHOYP_BRAFLDRAFT_118797.1.2 m.15033 sp PSF2_HUMAN 58.553 152 62 1 27 178 31 181 1.03E-61 192 PSF2_HUMAN reviewed DNA replication complex GINS protein PSF2 (GINS complex subunit 2) GINS2 PSF2 CGI-122 DC5 HSPC037 Homo sapiens (Human) 185 DNA duplex unwinding [GO:0032508]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975] GO:0000727; GO:0000811; GO:0005654; GO:0006271; GO:0031298; GO:0032508; GO:1902975 0 0 0 PF05916; A1L3G4 CHOYP_TM241.1.1 m.34353 sp TM241_XENLA 37.5 264 160 4 14 276 7 266 1.04E-48 168 TM241_XENLA reviewed Transmembrane protein 241 tmem241 Xenopus laevis (African clawed frog) 296 0 GO:0016021 0 0 0 0 A4IHY0 CHOYP_OXND1.2.2 m.41414 sp OXND1_XENTR 51.397 179 83 2 7 181 22 200 1.04E-58 189 OXND1_XENTR reviewed Oxidoreductase NAD-binding domain-containing protein 1 (EC 1.-.-.-) oxnad1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 314 0 GO:0005739; GO:0016491; GO:0071949 0 0 0 PF00175; A6QLI0 CHOYP_BRAFLDRAFT_129108.1.2 m.2456 sp EPDR1_BOVIN 29.31 174 114 4 28 195 52 222 1.04E-19 86.7 EPDR1_BOVIN reviewed Mammalian ependymin-related protein 1 (MERP-1) EPDR1 MERP1 Bos taurus (Bovine) 236 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; A7YY53 CHOYP_ADPRM.1.1 m.26139 sp ADPRM_BOVIN 43.925 321 165 5 32 340 18 335 1.04E-88 273 ADPRM_BOVIN reviewed Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.13) (EC 3.6.1.16) (EC 3.6.1.53) (ADPRibase-Mn) (CDP-choline phosphohydrolase) ADPRM Bos taurus (Bovine) 337 0 GO:0046872; GO:0047631; GO:0047734 0 0 0 PF00149; B0V3H4 CHOYP_LOC100466595.1.1 m.7073 sp CS054_DANRE 39.556 225 127 5 78 298 81 300 1.04E-44 157 CS054_DANRE reviewed UPF0692 protein C19orf54 homolog si:dkey-233h2.2 zgc:153119 Danio rerio (Zebrafish) (Brachydanio rerio) 307 0 0 0 0 0 0 B3RPX6 CHOYP_RSSA.9.10 m.60440 sp RSSA_TRIAD 80 80 16 0 7 86 24 103 1.04E-41 140 RSSA_TRIAD reviewed 40S ribosomal protein SA TRIADDRAFT_49917 Trichoplax adhaerens (Trichoplax reptans) 286 "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; ribosomal small subunit assembly [GO:0000028]; rRNA export from nucleus [GO:0006407]; translation [GO:0006412]" GO:0000028; GO:0000447; GO:0000461; GO:0003735; GO:0006407; GO:0006412; GO:0022627; GO:0030686 0 0 cd01425; PF00318; B4IC49 CHOYP_LOC100888344.1.1 m.3142 sp LST2_DROSE 44 75 42 0 19 93 876 950 1.04E-14 80.5 LST2_DROSE reviewed Lateral signaling target protein 2 homolog GM10129 Drosophila sechellia (Fruit fly) 975 0 GO:0046872 0 0 0 PF01363; E1BJS7 CHOYP_TVAG_127540.9.10 m.60161 sp LIN41_BOVIN 24.051 158 101 6 63 208 278 428 1.04E-08 59.3 LIN41_BOVIN reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Bos taurus (Bovine) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; F6QEU4 CHOYP_LOC100368020.26.29 m.50754 sp LIN41_XENTR 20.661 242 135 9 7 210 141 363 1.04E-07 55.1 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O08746 CHOYP_BRAFLDRAFT_234820.1.1 m.63193 sp MATN2_MOUSE 36.066 122 71 3 1 117 718 837 1.04E-15 75.1 MATN2_MOUSE reviewed Matrilin-2 Matn2 Mus musculus (Mouse) 956 axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; response to axon injury [GO:0048678] GO:0001764; GO:0005509; GO:0005578; GO:0005604; GO:0007411; GO:0008347; GO:0031104; GO:0031175; GO:0048678 0 0 0 PF07645;PF10393;PF00092; O16277 CHOYP_LOC100635715.2.9 m.8040 sp H16_CAEEL 56.471 85 36 1 1 84 41 125 1.04E-20 89 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O35309 CHOYP_BRAFLDRAFT_208436.29.32 m.61623 sp NMI_MOUSE 33.813 139 77 6 579 705 160 295 1.04E-06 54.7 NMI_MOUSE reviewed N-myc-interactor (Nmi) (N-myc and STAT interactor) Nmi Mus musculus (Mouse) 314 interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha biosynthetic process [GO:0045355]; negative regulation of interferon-beta biosynthetic process [GO:0045358]; negative regulation of type I interferon production [GO:0032480]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003712; GO:0005654; GO:0005737; GO:0006366; GO:0032480; GO:0045355; GO:0045358; GO:0045824; GO:0060333; GO:1902524 0 0 0 PF07334;PF07292; O42280 CHOYP_WNT9A.1.1 m.1633 sp WNT9A_CHICK 51.594 345 158 4 22 366 18 353 1.04E-125 368 WNT9A_CHICK reviewed Protein Wnt-9a (Wnt-14) WNT9A WNT14 Gallus gallus (Chicken) 354 cell fate commitment [GO:0045165]; cornea development in camera-type eye [GO:0061303]; embryonic skeletal joint development [GO:0072498]; iris morphogenesis [GO:0061072]; negative regulation of chondrocyte differentiation [GO:0032331]; neuron differentiation [GO:0030182]; positive regulation of embryonic skeletal joint development [GO:1902764]; Wnt signaling pathway [GO:0016055] GO:0005109; GO:0005578; GO:0005615; GO:0016055; GO:0030182; GO:0032331; GO:0045165; GO:0061072; GO:0061303; GO:0072498; GO:1902764 0 0 0 PF00110; O70277 CHOYP_BRAFLDRAFT_109858.3.6 m.32827 sp TRIM3_RAT 23.077 260 185 6 195 442 488 744 1.04E-10 67.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC100374342.16.19 m.60544 sp TRIM3_RAT 25.49 255 165 10 308 553 506 744 1.04E-09 65.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC100378574.1.1 m.32922 sp TRIM3_RAT 26.887 212 125 9 23 220 536 731 1.04E-06 52.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_MEG10.91.91 m.65595 sp MEGF6_HUMAN 37.993 279 153 11 1 274 766 1029 1.04E-36 143 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O93430 CHOYP_GLRA3.1.2 m.53461 sp GLRA1_DANRE 39.234 418 236 8 26 440 31 433 1.04E-98 305 GLRA1_DANRE reviewed Glycine receptor subunit alphaZ1 glra1 Danio rerio (Zebrafish) (Brachydanio rerio) 444 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; ion transport [GO:0006811]; neuropeptide signaling pathway [GO:0007218]; protein homooligomerization [GO:0051260]; regulation of neuron differentiation [GO:0045664]; response to amino acid [GO:0043200]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0006811; GO:0007218; GO:0007417; GO:0008270; GO:0016021; GO:0016594; GO:0016934; GO:0022824; GO:0030054; GO:0030425; GO:0034707; GO:0043200; GO:0043204; GO:0045211; GO:0045664; GO:0051260; GO:0060012; GO:0071230; GO:0071294; GO:0071361 0 0 0 PF02931;PF02932; O94868 CHOYP_FCSD2.1.1 m.52995 sp FCSD2_HUMAN 37.588 713 373 19 1 696 1 658 1.04E-139 431 FCSD2_HUMAN reviewed F-BAR and double SH3 domains protein 2 (Carom) (SH3 multiple domains protein 3) FCHSD2 KIAA0769 SH3MD3 Homo sapiens (Human) 740 0 0 0 0 0 PF00611;PF00018;PF14604; O96790 CHOYP_VOLCADRAFT_93060.1.2 m.3949 sp DPGN_DIPMA 34.314 306 132 11 685 921 27 332 1.04E-31 130 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P07572 CHOYP_LOC100494049.2.8 m.10781 sp POL_MPMV 27.014 211 125 8 89 286 69 263 1.04E-08 60.1 POL_MPMV reviewed Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) 867 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P10076 CHOYP_ZN845.1.2 m.14673 sp ZFP26_MOUSE 26.596 470 293 16 156 599 385 828 1.04E-23 111 ZFP26_MOUSE reviewed Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) 861 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; P10079 CHOYP_LOC100632098.7.13 m.38432 sp FBP1_STRPU 52.817 284 134 0 1 284 215 498 1.04E-91 296 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10394 CHOYP_LOC100371186.3.3 m.11102 sp POL4_DROME 27.641 1013 613 27 189 1138 276 1231 1.04E-97 344 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P10394 CHOYP_LOC100894010.2.6 m.7852 sp POL4_DROME 31.143 350 218 8 4 346 903 1236 1.04E-39 156 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P11369 CHOYP_LOC100536520.4.4 m.65674 sp LORF2_MOUSE 27.86 542 374 6 4 535 302 836 1.04E-49 187 LORF2_MOUSE reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) (Long interspersed element-1) (L1) (Retrovirus-related Pol polyprotein LINE-1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] Pol Gm17492 Mus musculus (Mouse) 1281 DNA recombination [GO:0006310] GO:0003964; GO:0004519; GO:0006310; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P16157 CHOYP_AFUA_1G01020.36.50 m.45201 sp ANK1_HUMAN 37.087 515 284 4 9 522 208 683 1.04E-81 281 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18172 CHOYP_LOC100118063.2.4 m.29108 sp DHGL_DROPS 37.59 556 322 9 90 639 65 601 1.04E-107 341 DHGL_DROPS reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) 625 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; P21328 CHOYP_LOC100367910.1.1 m.13407 sp RTJK_DROME 31.008 129 88 1 125 252 436 564 1.04E-10 65.1 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P22448 CHOYP_RARB.1.3 m.7166 sp RARB_CHICK 57.627 354 129 2 107 457 83 418 1.04E-143 421 RARB_CHICK reviewed Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2) RARB NR1B2 Gallus gallus (Chicken) 455 "beak morphogenesis [GO:0071729]; embryonic digestive tract development [GO:0048566]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration [GO:0070660]; limb morphogenesis [GO:0035108]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to retinoic acid [GO:0032526]; retinal pigment epithelium development [GO:0003406]; striatum development [GO:0021756]; transcription, DNA-templated [GO:0006351]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]" GO:0000122; GO:0000977; GO:0001657; GO:0002068; GO:0003148; GO:0003406; GO:0003417; GO:0003707; GO:0003708; GO:0005623; GO:0005654; GO:0006351; GO:0008270; GO:0008284; GO:0008285; GO:0021756; GO:0032331; GO:0032526; GO:0035108; GO:0035116; GO:0035264; GO:0043065; GO:0043066; GO:0045944; GO:0048048; GO:0048471; GO:0048566; GO:0055012; GO:0070660; GO:0071729 0 0 0 PF00104;PF00105; P30937 CHOYP_DGRI_GH14454.1.1 m.48744 sp SSR4_RAT 36 300 182 5 24 321 35 326 1.04E-60 203 SSR4_RAT reviewed Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) Sstr4 Rattus norvegicus (Rat) 384 "arachidonic acid metabolic process [GO:0019369]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; chemical synaptic transmission [GO:0007268]; forebrain development [GO:0030900]; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cAMP metabolic process [GO:0030815]; negative regulation of cell proliferation [GO:0008285]; positive regulation of MAPK cascade [GO:0043410]" GO:0004994; GO:0005737; GO:0005886; GO:0005887; GO:0007187; GO:0007268; GO:0008285; GO:0016477; GO:0019369; GO:0030815; GO:0030900; GO:0042923; GO:0043005; GO:0043410; GO:0071385 0 0 0 PF00001; P31944 CHOYP_LOC100927532.1.1 m.39625 sp CASPE_HUMAN 27.35 234 148 6 211 437 20 238 1.04E-18 88.2 CASPE_HUMAN reviewed "Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]" CASP14 Homo sapiens (Human) 242 cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424] GO:0004197; GO:0005634; GO:0005737; GO:0008544; GO:0031012; GO:0031424; GO:0045095; GO:0070062; GO:0070268; GO:0097153 0 0 0 0 P38942 CHOYP_ISCW_ISCW023591.1.1 m.9921 sp CAT2_CLOK5 50.474 422 203 4 43 463 13 429 1.04E-137 405 CAT2_CLOK5 reviewed 4-hydroxybutyrate coenzyme A transferase (EC 2.8.3.-) cat2 CKL_3018 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) 429 acetyl-CoA metabolic process [GO:0006084] GO:0006084; GO:0016740 0 0 0 PF13336;PF02550; P50867 CHOYP_LOC100377160.1.2 m.44263 sp CYSK_EMENI 66.977 215 70 1 27 240 34 248 1.04E-101 305 CYSK_EMENI reviewed Cysteine synthase 1 (CS 1) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 1) (OAS-TL 1) (O-acetylserine sulfhydrylase 1) cysB cysE AN8057 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 370 cellular amino acid biosynthetic process [GO:0008652]; cysteine biosynthetic process from serine [GO:0006535] GO:0004124; GO:0005737; GO:0005739; GO:0006535; GO:0008652; GO:0016740; GO:0030170 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2. {ECO:0000305|PubMed:17482430}. 0 0 PF00291; P56819 CHOYP_BACE1.1.1 m.52261 sp BACE1_RAT 48.552 449 217 9 58 504 56 492 1.04E-152 448 BACE1_RAT reviewed Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) Bace1 Bace Rattus norvegicus (Rat) 501 beta-amyloid metabolic process [GO:0050435]; membrane protein ectodomain proteolysis [GO:0006509]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508] GO:0001540; GO:0004190; GO:0005768; GO:0005771; GO:0005783; GO:0005794; GO:0005802; GO:0005887; GO:0006508; GO:0006509; GO:0008233; GO:0009986; GO:0030163; GO:0030424; GO:0030659; GO:0045121; GO:0050435 0 0 0 PF00026; P59222 CHOYP_PEAR1.6.16 m.37314 sp SREC2_MOUSE 38.136 118 67 4 196 311 226 339 1.04E-12 72 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P79781 CHOYP_UBB.2.3 m.63995 sp RS27A_CHICK 75.635 197 7 1 1 197 1 156 1.04E-87 257 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; P82251 CHOYP_BAT1.4.4 m.32273 sp BAT1_HUMAN 51.129 487 232 4 12 495 4 487 1.04E-162 473 BAT1_HUMAN reviewed "b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Homo sapiens (Human) 487 amino acid transport [GO:0006865]; L-cystine transport [GO:0015811]; leukocyte migration [GO:0050900]; neutral amino acid transport [GO:0015804]; protein complex assembly [GO:0006461] GO:0005886; GO:0005887; GO:0006461; GO:0006865; GO:0015175; GO:0015184; GO:0015297; GO:0015804; GO:0015811; GO:0016324; GO:0031526; GO:0042605; GO:0050900 0 0 0 PF13520; Q01484 CHOYP_RXR.1.2 m.45986 sp ANK2_HUMAN 25.128 585 353 20 376 926 219 752 1.04E-21 106 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q08420 CHOYP_LOC101169658.1.3 m.18820 sp SODE_RAT 29.268 164 96 7 318 467 65 222 1.04E-08 59.3 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q09654 CHOYP_TRIM3.35.58 m.38997 sp TRI23_CAEEL 27.647 170 98 7 4 151 118 284 1.04E-07 53.1 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q0EEE2 CHOYP_LOC100372915.2.7 m.22459 sp PTHD3_MOUSE 27.37 844 578 15 16 841 77 903 1.04E-106 354 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q10330 CHOYP_RCOM_0189880.2.2 m.25397 sp RL25A_SCHPO 50.794 63 31 0 38 100 5 67 1.04E-11 60.5 RL25A_SCHPO reviewed 60S ribosomal protein L25-A rpl2501 rpl25a SPBC106.18 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 141 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022625 0 0 0 PF00276;PF03939; Q10982 CHOYP_LOC100561462.1.1 m.23689 sp FUT2_PIG 30.584 291 183 7 51 335 54 331 1.04E-36 137 FUT2_PIG reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Sus scrofa (Pig) 340 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q22328 CHOYP_ISCW_ISCW023973.2.2 m.59851 sp LEV9_CAEEL 31.977 516 330 11 191 695 47 552 1.04E-76 261 LEV9_CAEEL reviewed Protein lev-9 lev-9 T07H6.5 Caenorhabditis elegans 622 0 GO:0005615; GO:0030054; GO:0030414; GO:0045202 0 0 0 PF00084;PF00095; Q28BQ6 CHOYP_BRAFLDRAFT_125388.1.1 m.15223 sp TMED1_XENTR 42.439 205 115 2 38 242 18 219 1.04E-53 175 TMED1_XENTR reviewed Transmembrane emp24 domain-containing protein 1 (p24 family protein gamma-1) (p24gamma1) tmed1 TNeu055d12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 220 protein transport [GO:0015031] GO:0005789; GO:0005794; GO:0005886; GO:0015031; GO:0016021; GO:0033116 0 0 0 PF01105; Q3EC11 CHOYP_LOC100368376.2.2 m.47943 sp ZDHC2_ARATH 30.178 507 311 13 186 662 28 521 1.04E-64 226 ZDHC2_ARATH reviewed Probable protein S-acyltransferase 23 (EC 2.3.1.225) (Probable palmitoyltransferase At2g14255) (Zinc finger DHHC domain-containing protein At2g14255) PAT23 At2g14255 T1O16.20 Arabidopsis thaliana (Mouse-ear cress) 536 0 GO:0000139; GO:0005794; GO:0008270; GO:0016021; GO:0019706 0 0 0 PF12796;PF01529; Q460N5 CHOYP_PARP14.11.22 m.46396 sp PAR14_HUMAN 33.607 122 71 5 5 123 1012 1126 1.04E-08 59.3 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q54Y55 CHOYP_BRAFLDRAFT_119173.1.4 m.6563 sp SHKC_DICDI 36.594 276 151 7 3 268 22 283 1.04E-46 177 SHKC_DICDI reviewed Dual specificity protein kinase shkC (EC 2.7.11.1) (SH2 domain-containing protein 3) (SH2 domain-containing protein C) shkC DDB_G0278409 Dictyostelium discoideum (Slime mold) 506 0 GO:0004674; GO:0004713; GO:0005524; GO:0016020; GO:0051219 0 0 0 PF07714;PF00017; Q5EBF8 CHOYP_ATRAP.2.2 m.26244 sp ATRAP_XENTR 36.81 163 95 3 1 162 1 156 1.04E-19 84 ATRAP_XENTR reviewed Type-1 angiotensin II receptor-associated protein-like agtrap TGas011p03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 163 angiotensin-activated signaling pathway [GO:0038166] GO:0016021; GO:0038166 0 0 0 PF06396; Q5M824 CHOYP_LOC100118291.1.1 m.54817 sp SHC1_RAT 41.667 504 221 12 16 507 23 465 1.04E-110 340 SHC1_RAT reviewed SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) Shc1 Rattus norvegicus (Rat) 469 actin cytoskeleton organization [GO:0030036]; activation of MAPK activity [GO:0000187]; aging [GO:0007568]; angiogenesis [GO:0001525]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; epidermal growth factor receptor signaling pathway [GO:0007173]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; organ regeneration [GO:0031100]; positive regulation of DNA replication [GO:0045740]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of vasoconstriction [GO:0045907]; regulation of growth [GO:0040008]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to nicotine [GO:0035094]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636] GO:0000187; GO:0001525; GO:0001666; GO:0001784; GO:0005154; GO:0005634; GO:0005737; GO:0005886; GO:0007173; GO:0007568; GO:0008286; GO:0009636; GO:0010008; GO:0014070; GO:0030036; GO:0030182; GO:0030971; GO:0031100; GO:0031175; GO:0032403; GO:0032868; GO:0032869; GO:0035094; GO:0035556; GO:0040008; GO:0042542; GO:0045740; GO:0045907; GO:0048661; GO:0051219; GO:0051384; GO:0051721; GO:0070435; GO:0071363 0 0 0 PF00640;PF00017; Q5R978 CHOYP_TTLL5.1.1 m.40429 sp TTLL5_PONAB 48.187 193 82 3 3 188 669 850 1.04E-33 140 TTLL5_PONAB reviewed Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 5) TTLL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1299 "cellular protein modification process [GO:0006464]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005634; GO:0005737; GO:0005874; GO:0005929; GO:0006351; GO:0006464; GO:0016874 0 0 0 PF03133; Q5RA37 CHOYP_RPAP2.1.1 m.13955 sp RPAP2_PONAB 49.286 140 70 1 6 145 44 182 1.04E-36 148 RPAP2_PONAB reviewed Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) RPAP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 612 dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; snRNA transcription [GO:0009301] GO:0005634; GO:0005737; GO:0008420; GO:0009301; GO:0016591; GO:0046872; GO:0070940 0 0 0 PF04181; Q5SZI1 CHOYP_BRAFLDRAFT_124864.1.2 m.51293 sp LRAD2_HUMAN 38.028 71 40 3 122 190 137 205 1.04E-06 52 LRAD2_HUMAN reviewed Low-density lipoprotein receptor class A domain-containing protein 2 LDLRAD2 Homo sapiens (Human) 272 0 GO:0016021 0 0 0 PF00057; Q5U2S5 CHOYP_SNX24.1.1 m.8889 sp SNX24_RAT 38.415 164 93 3 24 181 1 162 1.04E-24 97.8 SNX24_RAT reviewed Sorting nexin-24 Snx24 Rattus norvegicus (Rat) 169 protein transport [GO:0015031] GO:0010314; GO:0015031; GO:0030659; GO:0032266; GO:0070273 0 0 0 PF00787; Q5URB8 CHOYP_YL122.1.2 m.50223 sp YR841_MIMIV 28.481 158 101 5 10 155 318 475 1.04E-06 54.3 YR841_MIMIV reviewed Putative ankyrin repeat protein R841 MIMI_R841 Acanthamoeba polyphaga mimivirus (APMV) 601 0 0 0 0 0 PF00023;PF12796; Q5XI67 CHOYP_FBX40.2.2 m.55475 sp FBX30_RAT 36.475 244 101 4 334 574 515 707 1.04E-40 161 FBX30_RAT reviewed F-box only protein 30 Fbxo30 Rattus norvegicus (Rat) 742 0 GO:0008270; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15966;PF15965; Q6AXP3 CHOYP_BRAFLDRAFT_118523.1.1 m.11471 sp F227B_RAT 26.655 574 318 15 28 585 2 488 1.04E-54 198 F227B_RAT reviewed Protein FAM227B Fam227b Rattus norvegicus (Rat) 573 0 0 0 0 0 PF14922; Q6BD04 CHOYP_LOC100889710.1.1 m.43739 sp GPR54_ORENI 34.797 296 183 4 23 316 45 332 1.04E-56 190 GPR54_ORENI reviewed G-protein coupled receptor 54 gpr54 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 377 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q6DF46 CHOYP_LOC100889564.1.1 m.17149 sp COQ6_XENTR 51.322 454 217 2 17 470 14 463 1.04E-161 468 COQ6_XENTR reviewed "Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6)" coq6 TEgg013o11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 464 secondary metabolite biosynthetic process [GO:0044550]; ubiquinone biosynthetic process [GO:0006744] GO:0004497; GO:0005739; GO:0005794; GO:0006744; GO:0016709; GO:0016712; GO:0031314; GO:0042995; GO:0044550; GO:0071949 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03193}. 0 0 PF01494; Q6IMH0 CHOYP_LOC100179516.1.2 m.45110 sp TEPP_MOUSE 40.441 136 63 3 14 135 61 192 1.04E-24 97.4 TEPP_MOUSE reviewed "Testis, prostate and placenta-expressed protein" Tepp Mus musculus (Mouse) 216 0 0 0 0 0 0 Q6IRM9 CHOYP_ZWILC.1.1 m.14682 sp ZWILC_XENLA 26.223 511 341 12 129 616 88 585 1.04E-46 177 ZWILC_XENLA reviewed Protein zwilch homolog zwilch Xenopus laevis (African clawed frog) 597 cell division [GO:0051301]; mitotic cell cycle checkpoint [GO:0007093]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0007067; GO:0007093; GO:0051301; GO:1990423 0 0 0 PF09817; Q6NS15 CHOYP_MED15.3.3 m.43825 sp MED15_XENLA 52.431 288 126 5 373 657 494 773 1.04E-84 285 MED15_XENLA reviewed Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (xARC105) (Mediator complex subunit 15) med15 arc105 Xenopus laevis (African clawed frog) 777 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0005737; GO:0006351; GO:0016592 0 0 0 PF09606; Q6PCR7 CHOYP_BRAFLDRAFT_75590.1.1 m.29549 sp EIF3A_DANRE 48.387 155 80 0 1 155 670 824 1.04E-31 122 EIF3A_DANRE reviewed Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) eif3a eif3s10 Danio rerio (Zebrafish) (Brachydanio rerio) 1267 formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446] GO:0001731; GO:0001732; GO:0003743; GO:0005852; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF01399; Q6Q899 CHOYP_LOC100378083.3.3 m.65631 sp DDX58_MOUSE 27.657 734 458 23 52 748 196 893 1.04E-51 198 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6R5N8 CHOYP_LOC100767676.1.1 m.21833 sp TLR13_MOUSE 27.019 966 574 26 7 874 51 983 1.04E-56 214 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q6ZRF8 CHOYP_LOC100375954.3.6 m.32672 sp RN207_HUMAN 21.951 205 142 7 22 218 100 294 1.04E-08 60.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZU67 CHOYP_BEND4.1.1 m.7515 sp BEND4_HUMAN 31.496 127 80 4 3 123 371 496 1.04E-10 61.2 BEND4_HUMAN reviewed BEN domain-containing protein 4 (Coiled-coil domain-containing protein 4) BEND4 CCDC4 Homo sapiens (Human) 534 0 0 0 0 0 PF10523; Q7QB13 CHOYP_CCNC.1.1 m.15538 sp CCNC_ANOGA 72.075 265 73 1 1 265 1 264 1.04E-143 407 CCNC_ANOGA reviewed Cyclin-C CycC AGAP004240 Anopheles gambiae (African malaria mosquito) 266 "positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of phosphorylation of RNA polymerase II C-terminal domain [GO:1901409]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000307; GO:0005634; GO:0006351; GO:0016538; GO:0045737; GO:0045944; GO:1901409 0 0 0 PF16899;PF00134; Q86WC4 CHOYP_OSTM1.1.1 m.26674 sp OSTM1_HUMAN 28.627 255 155 5 89 329 84 325 1.04E-25 108 OSTM1_HUMAN reviewed Osteopetrosis-associated transmembrane protein 1 (Chloride channel 7 beta subunit) OSTM1 GL HSPC019 UNQ6098/PRO21201 Homo sapiens (Human) 334 ion transmembrane transport [GO:0034220]; osteoclast differentiation [GO:0030316] GO:0005634; GO:0005737; GO:0005765; GO:0005829; GO:0016021; GO:0030316; GO:0034220; GO:0043231 0 0 0 PF09777; Q8BLQ9 CHOYP_DHX8.3.3 m.65323 sp CADM2_MOUSE 24.194 310 189 13 26 329 31 300 1.04E-11 70.5 CADM2_MOUSE reviewed Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2) Cadm2 Igsf4d Necl3 Mus musculus (Mouse) 435 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0030424; GO:0042803; GO:0045202; GO:0050839 0 0 0 PF08205;PF07686; Q8BXX9 CHOYP_LOC100375592.2.6 m.27205 sp CC169_MOUSE 32.432 111 61 4 1 110 111 208 1.04E-08 55.5 CC169_MOUSE reviewed Coiled-coil domain-containing protein 169 Ccdc169 Mus musculus (Mouse) 214 0 0 0 0 0 PF15372; Q8BXX9 CHOYP_LOC100375592.4.6 m.38107 sp CC169_MOUSE 36.364 176 100 6 29 202 47 212 1.04E-23 96.7 CC169_MOUSE reviewed Coiled-coil domain-containing protein 169 Ccdc169 Mus musculus (Mouse) 214 0 0 0 0 0 PF15372; Q8K4Q6 CHOYP_LOC100703866.1.2 m.44331 sp NEIL1_MOUSE 49.231 325 152 5 1 317 1 320 1.04E-103 315 NEIL1_MOUSE reviewed Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (Nei homolog 1) (NEH1) (Nei-like protein 1) Neil1 Nei1 Mus musculus (Mouse) 389 base-excision repair [GO:0006284]; DNA repair [GO:0006281]; negative regulation of nuclease activity [GO:0032074]; nucleotide-excision repair [GO:0006289]; response to oxidative stress [GO:0006979] GO:0003684; GO:0003906; GO:0005634; GO:0005694; GO:0005737; GO:0005815; GO:0006281; GO:0006284; GO:0006289; GO:0006979; GO:0008022; GO:0008270; GO:0016798; GO:0016829; GO:0019104; GO:0032074 0 0 0 PF01149;PF06831;PF09292; Q8N6T7 CHOYP_LOC100375279.1.1 m.42202 sp SIR6_HUMAN 62.411 282 105 1 1 281 1 282 1.04E-130 384 SIR6_HUMAN reviewed NAD-dependent protein deacetylase sirtuin-6 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 6) (SIR2-like protein 6) SIRT6 SIR2L6 Homo sapiens (Human) 355 "base-excision repair [GO:0006284]; glucose homeostasis [GO:0042593]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glucose import [GO:0046325]; negative regulation of glycolytic process [GO:0045820]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of stem cell proliferation [GO:2000648]; post-embryonic cardiac muscle cell growth involved in heart morphogenesis [GO:0003247]; protein ADP-ribosylation [GO:0006471]; protein destabilization [GO:0031648]; regulation of double-strand break repair via homologous recombination [GO:0010569]; response to nutrient levels [GO:0031667]" GO:0003247; GO:0003682; GO:0003714; GO:0003950; GO:0003956; GO:0005634; GO:0005654; GO:0005724; GO:0005737; GO:0006284; GO:0006471; GO:0008270; GO:0008285; GO:0010569; GO:0017136; GO:0031648; GO:0031667; GO:0034979; GO:0042593; GO:0045820; GO:0045892; GO:0046325; GO:0046969; GO:0048146; GO:0070403; GO:2000648 0 0 0 PF02146; Q8QGW7 CHOYP_LOC100369143.1.2 m.59315 sp LITAF_CHICK 46.667 105 53 2 63 166 46 148 1.04E-22 90.9 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8TB52 CHOYP_Y7243.1.1 m.35954 sp FBX30_HUMAN 37.209 86 39 2 191 267 4 83 1.04E-09 64.7 FBX30_HUMAN reviewed F-box only protein 30 FBXO30 FBX30 Homo sapiens (Human) 745 0 GO:0008270; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15966;PF15965; Q8WY91 CHOYP_LOC100376482.1.7 m.7553 sp THAP4_HUMAN 40.566 106 39 6 1 103 1 85 1.04E-08 62.4 THAP4_HUMAN reviewed THAP domain-containing protein 4 THAP4 CGI-36 PP238 Homo sapiens (Human) 577 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q90YR8 CHOYP_RS6.2.12 m.2811 sp RS6_ICTPU 87.209 86 11 0 1 86 1 86 1.04E-52 168 RS6_ICTPU reviewed 40S ribosomal protein S6 rps6 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 249 glucose homeostasis [GO:0042593]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0006412; GO:0022627; GO:0042593; GO:0048471 0 0 0 PF01092; Q91YD4 CHOYP_TRPM2.3.12 m.33757 sp TRPM2_MOUSE 21.377 828 470 29 81 836 166 884 1.04E-25 118 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q965M2 CHOYP_DWIL_GK13202.1.1 m.24870 sp SMA10_CAEEL 28.698 338 222 10 69 391 105 438 1.04E-20 97.8 SMA10_CAEEL reviewed Leucine-rich repeats and immunoglobulin-like domains protein sma-10 sma-10 T21D12.9 Caenorhabditis elegans 881 positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005114; GO:0005887; GO:0007179; GO:0030511; GO:0030659; GO:0031225; GO:0034713; GO:0040018 0 0 0 PF07679;PF13855; Q98943 CHOYP_BRAFLDRAFT_82806.1.1 m.34879 sp CASP2_CHICK 33.333 108 72 0 160 267 3 110 1.04E-09 62.8 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q99M02 CHOYP_MARCH3.1.1 m.47151 sp MARH2_MOUSE 39.645 169 100 1 85 251 49 217 1.04E-38 144 MARH2_MOUSE reviewed E3 ubiquitin-protein ligase MARCH2 (EC 6.3.2.-) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) 2-Mar Mus musculus (Mouse) 246 endocytosis [GO:0006897]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005765; GO:0005783; GO:0005789; GO:0006897; GO:0008270; GO:0010008; GO:0016021; GO:0016567; GO:0016874; GO:0031410 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q9BMX5 CHOYP_RS6.3.12 m.5755 sp RS6_APLCA 79.535 215 39 2 1 210 32 246 1.04E-120 345 RS6_APLCA reviewed 40S ribosomal protein S6 RPS6 Aplysia californica (California sea hare) 247 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01092; Q9D187 CHOYP_LOC496139.1.1 m.39321 sp MIP18_MOUSE 75 152 38 0 15 166 12 163 1.04E-79 236 MIP18_MOUSE reviewed Mitotic spindle-associated MMXD complex subunit MIP18 (Protein FAM96B) Fam96b Mip18 Mus musculus (Mouse) 163 chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226] GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0007059; GO:0016226; GO:0071817; GO:0097361 0 0 0 PF01883; Q9ESN6 CHOYP_BRAFLDRAFT_79377.19.30 m.42413 sp TRIM2_MOUSE 25.551 227 151 8 220 436 489 707 1.04E-11 70.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC100374741.33.83 m.32677 sp TRIM2_MOUSE 24.79 238 145 10 295 514 484 705 1.04E-10 67.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GNN8 CHOYP_CTXA.1.2 m.31637 sp CTXA_CARAL 20.228 351 206 13 74 366 129 463 1.04E-07 57.4 CTXA_CARAL reviewed Toxin CaTX-A (Toxin A) (CAT-1) 0 Carybdea alata (Hawaiian box jellyfish) 463 hemolysis in other organism [GO:0044179]; ion transport [GO:0006811] GO:0005576; GO:0006811; GO:0016021; GO:0042151; GO:0044179; GO:0044218 0 0 0 0 Q9HCK0 CHOYP_ZN555.1.1 m.65569 sp ZBT26_HUMAN 28.986 138 78 3 596 729 258 379 1.04E-07 58.5 ZBT26_HUMAN reviewed Zinc finger and BTB domain-containing protein 26 (Zinc finger protein 481) (Zinc finger protein Bioref) ZBTB26 KIAA1572 ZNF481 Homo sapiens (Human) 441 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF00096; Q9I8C7 CHOYP_ACHA9.1.3 m.33600 sp ACH10_CHICK 45.679 324 170 3 31 354 33 350 1.04E-97 306 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9MYM7 CHOYP_LOC100903911.1.1 m.58977 sp B3GT1_PONPY 36.441 236 137 7 73 307 53 276 1.04E-36 138 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9N0C7 CHOYP_BRAFLDRAFT_269209.1.1 m.4682 sp EPDR1_MACFA 32.292 96 60 2 4 97 118 210 1.04E-10 58.9 EPDR1_MACFA reviewed Mammalian ependymin-related protein 1 (MERP-1) EPDR1 MERP1 QccE-12983 QmoA-12340 QmoA-13475 QtrA-11871 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00811; Q9NZ56 CHOYP_FMN2.1.1 m.54926 sp FMN2_HUMAN 45.551 472 246 6 19 484 1255 1721 1.04E-123 399 FMN2_HUMAN reviewed Formin-2 FMN2 Homo sapiens (Human) 1722 cellular response to DNA damage stimulus [GO:0006974]; cellular response to hypoxia [GO:0071456]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; homologous chromosome movement towards spindle pole involved in homologous chromosome segregation [GO:0051758]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; oogenesis [GO:0048477]; polar body extrusion after meiotic divisions [GO:0040038]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0003779; GO:0005730; GO:0005789; GO:0005819; GO:0005829; GO:0005886; GO:0005902; GO:0005938; GO:0006974; GO:0007275; GO:0015031; GO:0016192; GO:0030659; GO:0035556; GO:0040038; GO:0042177; GO:0043066; GO:0046907; GO:0048471; GO:0048477; GO:0051295; GO:0051758; GO:0070649; GO:0071456 0 0 0 PF06346;PF02181; Q9P215 CHOYP_LOC100488868.1.1 m.65338 sp POGK_HUMAN 39.189 74 39 3 10 78 537 609 1.04E-06 48.9 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9R050 CHOYP_LOC662190.3.3 m.62554 sp SSBP3_RAT 55.673 379 103 16 10 368 1 334 1.04E-78 250 SSBP3_RAT reviewed Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) Ssbp3 Ssdp Ssdp1 Ssdp3 Rattus norvegicus (Rat) 361 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003697; GO:0005634; GO:0006351; GO:0006355 0 0 0 0 Q9UKK3 CHOYP_PARP4.1.2 m.15204 sp PARP4_HUMAN 47.222 252 130 2 3 251 960 1211 1.04E-62 236 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9VCA8 CHOYP_LOC100635111.1.13 m.41 sp ANKHM_DROME 34.899 298 163 11 755 1034 550 834 1.04E-28 129 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VUL9 CHOYP_LOC663102.1.1 m.8869 sp FUCTA_DROME 31.195 343 187 12 71 402 175 479 1.04E-39 151 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q9WV92 CHOYP_LOC100373842.4.4 m.40731 sp E41L3_MOUSE 57.925 347 140 4 61 406 113 454 1.04E-135 431 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; Q9Y1C1 CHOYP_EMAP.1.2 m.15797 sp EMAP_LYTVA 62.136 103 37 1 1 103 131 231 1.04E-37 136 EMAP_LYTVA reviewed 77 kDa echinoderm microtubule-associated protein (Fragment) EMAP Lytechinus variegatus (Green sea urchin) (Variegated urchin) 664 0 GO:0005737; GO:0005874 0 0 0 PF03451;PF00400; Q9Y5Q8 CHOYP_BRAFLDRAFT_57181.1.1 m.19161 sp TF3C5_HUMAN 35.484 527 285 16 24 518 16 519 1.04E-95 303 TF3C5_HUMAN reviewed General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon) GTF3C5 CDABP0017 Homo sapiens (Human) 519 "5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; skeletal muscle cell differentiation [GO:0035914]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase III promoter [GO:0006383]; tRNA transcription from RNA polymerase III promoter [GO:0042797]" GO:0000127; GO:0003677; GO:0005654; GO:0006351; GO:0006383; GO:0035914; GO:0042791; GO:0042797 0 0 0 PF09734; A0JM12 CHOYP_MEGF6.3.59 m.2378 sp MEG10_XENTR 36.223 323 171 14 135 454 68 358 1.05E-31 133 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AJ76 CHOYP_BRAFLDRAFT_233007.1.1 m.23315 sp HMCN2_MOUSE 40.244 164 90 6 2 158 4668 4830 1.05E-32 127 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A2AX52 CHOYP_LOC100708991.2.5 m.29236 sp CO6A4_MOUSE 22.9 869 557 24 6 834 409 1204 1.05E-42 176 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A4IF63 CHOYP_TRIM2.46.59 m.53209 sp TRIM2_BOVIN 24.183 153 105 2 435 586 602 744 1.05E-07 58.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_TRIM3.14.58 m.21272 sp TRIM2_BOVIN 24.155 207 151 4 138 340 540 744 1.05E-09 63.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5PLL7 CHOYP_AAEL_AAEL001208.1.1 m.27091 sp TM189_HUMAN 65.748 254 87 0 41 294 15 268 1.05E-125 362 TM189_HUMAN reviewed Transmembrane protein 189 TMEM189 KUA Homo sapiens (Human) 270 0 GO:0005737; GO:0005789; GO:0016021; GO:0031625; GO:0061630 0 0 0 PF10520; A6H791 CHOYP_BRAFLDRAFT_114350.1.1 m.14176 sp TRM61_BOVIN 53.208 265 122 2 1 263 1 265 1.05E-105 314 TRM61_BOVIN reviewed tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) TRMT61A TRM61 Bos taurus (Bovine) 285 0 GO:0005634; GO:0016429; GO:0031515 0 0 0 PF08704; B3DK56 CHOYP_LOC100638857.1.1 m.56860 sp PTPRU_DANRE 31.818 198 123 7 5 196 995 1186 1.05E-20 93.6 PTPRU_DANRE reviewed Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) ptpru rptppsi Danio rerio (Zebrafish) (Brachydanio rerio) 1444 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; somite specification [GO:0001757] GO:0001757; GO:0004725; GO:0005886; GO:0007155; GO:0016021; GO:0030054; GO:0030154 0 0 cd06263; PF00041;PF00629;PF00102; D3ZD32 CHOYP_LOC100160983.1.1 m.2368 sp CHD5_RAT 43.391 348 127 9 119 433 125 435 1.05E-65 231 CHD5_RAT reviewed Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) Chd5 Rattus norvegicus (Rat) 1948 "cerebral cortex neuron differentiation [GO:0021895]; histone H3-K27 trimethylation [GO:0098532]; histone H4 acetylation [GO:0043967]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription involved in cell fate commitment [GO:0060850]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000792; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0006366; GO:0008026; GO:0008270; GO:0016581; GO:0021895; GO:0035093; GO:0043967; GO:0060850; GO:0061628; GO:0098532; GO:1901798 0 0 0 PF08074;PF08073;PF00385;PF06461;PF06465;PF00271;PF00628;PF00176; D4DDK2 CHOYP_RCF1.1.2 m.28968 sp RCF1_TRIVH 28.037 107 77 0 56 162 2 108 1.05E-09 58.2 RCF1_TRIVH reviewed "Respiratory supercomplex factor 1, mitochondrial" RCF1 AIM31 TRV_05213 Trichophyton verrucosum (strain HKI 0517) 189 mitochondrial respiratory chain complex IV assembly [GO:0033617]; mitochondrial respiratory chain supercomplex assembly [GO:0097250] GO:0031305; GO:0033617; GO:0097249; GO:0097250 0 0 0 PF04588; O18870 CHOYP_SMN2.1.2 m.24147 sp SMN_BOVIN 36.918 279 145 9 14 272 14 281 1.05E-37 137 SMN_BOVIN reviewed Survival motor neuron protein SMN1 SMN Bos taurus (Bovine) 287 "axonogenesis [GO:0007409]; DNA-templated transcription, termination [GO:0006353]; microtubule depolymerization [GO:0007019]; positive regulation of RNA splicing [GO:0033120]; regulation of neuron projection development [GO:0010975]; spliceosomal snRNP assembly [GO:0000387]" GO:0000387; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006353; GO:0007019; GO:0007409; GO:0010975; GO:0015030; GO:0030018; GO:0032797; GO:0033120; GO:0034719; GO:0036464; GO:0043005; GO:0043204; GO:0097504 0 0 0 PF06003; O43301 CHOYP_BRAFLDRAFT_208436.20.32 m.58898 sp HS12A_HUMAN 29.706 579 334 14 7 528 53 615 1.05E-68 238 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O50655 CHOYP_LOC100634483.1.1 m.17094 sp XERD_SELRU 26.299 308 206 8 5 301 42 339 1.05E-17 85.5 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O54827 CHOYP_ISCW_ISCW018337.1.1 m.23194 sp AT10A_MOUSE 42.938 177 95 1 1 177 339 509 1.05E-39 146 AT10A_MOUSE reviewed Probable phospholipid-transporting ATPase VA (EC 3.6.3.1) (ATPase class V type 10A) (P-locus fat-associated ATPase) (P4-ATPase flippase complex alpha subunit ATP10A) Atp10a Atpc5 Pfatp Mus musculus (Mouse) 1508 0 GO:0000287; GO:0004012; GO:0005524; GO:0005783; GO:0005789; GO:0005886; GO:0016021 0 0 0 PF00122;PF16212;PF16209; O70306 CHOYP_TBX20.3.4 m.49132 sp TBX15_MOUSE 51.152 217 89 2 66 269 108 320 1.05E-67 228 TBX15_MOUSE reviewed T-box transcription factor TBX15 (T-box protein 15) (MmTBx8) (T-box transcription factor TBX14) (T-box protein 14) Tbx15 Tbx14 Tbx8 Mus musculus (Mouse) 602 "embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic skeletal system morphogenesis [GO:0048704]; transcription, DNA-templated [GO:0006351]" GO:0000976; GO:0000978; GO:0001078; GO:0001106; GO:0005634; GO:0006351; GO:0042803; GO:0046982; GO:0048701; GO:0048704 0 0 0 PF00907; O70528 CHOYP_LOC100887891.1.1 m.18936 sp 5HT4R_CAVPO 26.837 313 203 6 21 309 13 323 1.05E-26 111 5HT4R_CAVPO reviewed 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) 388 chemical synaptic transmission [GO:0007268]; regulation of appetite [GO:0032098] GO:0004993; GO:0005768; GO:0005887; GO:0007268; GO:0032098 0 0 0 PF00001; O75095 CHOYP_CED1.17.29 m.40281 sp MEGF6_HUMAN 33.663 303 186 8 58 358 707 996 1.05E-37 151 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75382 CHOYP_BRAFLDRAFT_87325.1.11 m.386 sp TRIM3_HUMAN 27.273 121 83 3 288 405 624 742 1.05E-06 54.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O95786 CHOYP_DDX58.9.9 m.62757 sp DDX58_HUMAN 32.518 695 424 18 87 763 241 908 1.05E-95 322 DDX58_HUMAN reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Homo sapiens (Human) 925 cytoplasmic pattern recognition receptor signaling pathway in response to virus [GO:0039528]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of type III interferon production [GO:0034344]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0034344; GO:0039528; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944; GO:0051091 0 0 0 PF16739;PF00270;PF00271;PF11648; P01130 CHOYP_LDLR.6.7 m.57985 sp LDLR_HUMAN 59.091 66 26 1 69 133 80 145 1.05E-18 84.3 LDLR_HUMAN reviewed Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899] GO:0001618; GO:0001948; GO:0002020; GO:0004872; GO:0005041; GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005887; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0008203; GO:0009897; GO:0009986; GO:0010008; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0030669; GO:0032050; GO:0034362; GO:0034383; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0070508; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P07463 CHOYP_LOC100377516.1.1 m.16663 sp CALM_PARTE 35.461 141 87 3 49 186 5 144 1.05E-21 89.4 CALM_PARTE reviewed Calmodulin (CaM) CAM GSPATT00015825001 Paramecium tetraurelia 149 0 GO:0005509 0 0 0 PF13499; P10079 CHOYP_LOC100208285.1.2 m.19884 sp FBP1_STRPU 39.51 572 287 13 1959 2478 179 743 1.05E-106 373 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10394 CHOYP_LOC100372999.3.3 m.53717 sp POL4_DROME 36.649 382 231 5 397 770 310 688 1.05E-64 238 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P15941 CHOYP_LOC100929680.2.2 m.28318 sp MUC1_HUMAN 37.146 918 461 32 1247 2098 75 942 1.05E-48 196 MUC1_HUMAN reviewed Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] MUC1 PUM Homo sapiens (Human) 1255 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; O-glycan processing [GO:0016266]; positive regulation of histone H4 acetylation [GO:0090240]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]" GO:0000790; GO:0000978; GO:0002039; GO:0003712; GO:0005615; GO:0005796; GO:0005887; GO:0006977; GO:0006978; GO:0010944; GO:0016266; GO:0016324; GO:0031982; GO:0033629; GO:0036003; GO:0043618; GO:0070062; GO:0090240; GO:1902166 0 0 0 PF01390; P16554 CHOYP_NUMB.1.1 m.19732 sp NUMB_DROME 55.814 344 108 8 14 330 57 383 1.05E-114 353 NUMB_DROME reviewed Protein numb numb CG3779 Drosophila melanogaster (Fruit fly) 556 asymmetric cell division [GO:0008356]; asymmetric neuroblast division [GO:0055059]; cell fate commitment [GO:0045165]; cell fate determination [GO:0001709]; central nervous system development [GO:0007417]; centrosome localization [GO:0051642]; embryonic heart tube development [GO:0035050]; glial cell migration [GO:0008347]; heart development [GO:0007507]; Malpighian tubule tip cell differentiation [GO:0061382]; muscle cell fate specification [GO:0042694]; negative regulation of Notch signaling pathway [GO:0045746]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; Notch signaling pathway [GO:0007219]; pericardial nephrocyte differentiation [GO:0061320]; peripheral nervous system development [GO:0007422]; positive regulation of endocytosis [GO:0045807]; protein localization [GO:0008104]; regulation of asymmetric cell division [GO:0009786]; regulation of nervous system development [GO:0051960]; regulation of neurogenesis [GO:0050767]; regulation of Notch signaling pathway [GO:0008593]; rhythmic behavior [GO:0007622]; sensory organ precursor cell division [GO:0045035]; sensory organ precursor cell fate determination [GO:0016360]; ventral cord development [GO:0007419] GO:0001709; GO:0005112; GO:0005524; GO:0005634; GO:0005737; GO:0005938; GO:0007219; GO:0007400; GO:0007405; GO:0007417; GO:0007419; GO:0007422; GO:0007507; GO:0007622; GO:0008104; GO:0008347; GO:0008356; GO:0008593; GO:0009786; GO:0016360; GO:0035050; GO:0042694; GO:0045035; GO:0045165; GO:0045178; GO:0045180; GO:0045746; GO:0045807; GO:0050767; GO:0051642; GO:0051960; GO:0055059; GO:0061320; GO:0061382 0 0 0 PF06311;PF00640; P20965 CHOYP_LOC100370010.4.5 m.25251 sp PABPA_XENLA 67.391 230 74 1 1 230 161 389 1.05E-102 315 PABPA_XENLA reviewed Polyadenylate-binding protein 1-A (PABP-1-A) (Poly(A)-binding protein 1-A) (xPABP1-A) (Cytoplasmic poly(A)-binding protein 1-A) pabpc1-a pabp pabp1 Xenopus laevis (African clawed frog) 633 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of translation [GO:0006417]; translation [GO:0006412]" GO:0000166; GO:0005737; GO:0005844; GO:0006397; GO:0006412; GO:0006417; GO:0008143; GO:0031047; GO:0031370; GO:0043621; GO:0048255; GO:0060212; GO:0060213; GO:1900153 0 0 0 PF00658;PF00076; P23610 CHOYP_BRAFLDRAFT_115297.1.1 m.64584 sp F8I2_HUMAN 45.739 352 149 7 23 333 21 371 1.05E-73 234 F8I2_HUMAN reviewed Factor VIII intron 22 protein (CpG island protein) F8A1 F8A; F8A2 F8A; F8A3 F8A Homo sapiens (Human) 371 0 GO:0005634 0 0 0 0 P28828 CHOYP_PTPRG.1.3 m.56419 sp PTPRM_MOUSE 34.799 546 324 10 858 1382 918 1452 1.05E-85 311 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P35543 CHOYP_BRAFLDRAFT_124064.1.6 m.5119 sp SAA3_RABIT 54.615 130 45 2 7 136 5 120 1.05E-44 145 SAA3_RABIT reviewed Serum amyloid A-3 protein SAA3 Oryctolagus cuniculus (Rabbit) 122 acute-phase response [GO:0006953] GO:0006953; GO:0034364 0 0 0 PF00277; P37889 CHOYP_LOC100634184.3.3 m.16081 sp FBLN2_MOUSE 41.86 344 169 14 196 513 780 1118 1.05E-60 221 FBLN2_MOUSE reviewed Fibulin-2 (FIBL-2) Fbln2 Mus musculus (Mouse) 1221 positive regulation of cell-substrate adhesion [GO:0010811] GO:0005509; GO:0005578; GO:0010811; GO:0031012; GO:0050840; GO:0070062; GO:1903561 0 0 0 PF01821;PF12662;PF07645; P41385 CHOYP_contig_015657 m.18314 sp TBB_BOMMO 58.065 93 30 2 1 84 233 325 1.05E-26 105 TBB_BOMMO reviewed Tubulin beta chain (Beta-tubulin) 0 Bombyx mori (Silk moth) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P41731 CHOYP_BRAFLDRAFT_124708.1.2 m.18356 sp CD63_MOUSE 40.87 115 68 0 2 116 3 117 1.05E-19 83.6 CD63_MOUSE reviewed CD63 antigen (CD antigen CD63) Cd63 Mus musculus (Mouse) 238 cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cellular protein localization [GO:0034613]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigmentation [GO:0043473]; pigment cell differentiation [GO:0050931]; pigment granule maturation [GO:0048757]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endocytosis [GO:0045807]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of rubidium ion transport [GO:2000680]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005615; GO:0005764; GO:0005765; GO:0005770; GO:0005887; GO:0007155; GO:0007160; GO:0009986; GO:0010008; GO:0010633; GO:0015031; GO:0016477; GO:0030855; GO:0031226; GO:0031902; GO:0031904; GO:0032585; GO:0034613; GO:0035646; GO:0042470; GO:0043234; GO:0043473; GO:0045785; GO:0045807; GO:0048757; GO:0050931; GO:0070062; GO:0097487; GO:1900746; GO:2000680; GO:2001046 0 0 0 PF00335; P59222 CHOYP_LOC579946.13.24 m.47714 sp SREC2_MOUSE 40.12 167 91 6 228 391 265 425 1.05E-22 105 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P62489 CHOYP_RPB7.1.1 m.27807 sp RPB7_RAT 89.222 167 18 0 53 219 4 170 1.05E-109 315 RPB7_RAT reviewed DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) Polr2g Rattus norvegicus (Rat) 172 "apoptotic process [GO:0006915]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translational initiation [GO:0045948]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000291; GO:0000932; GO:0003697; GO:0003727; GO:0003899; GO:0005634; GO:0005665; GO:0006366; GO:0006367; GO:0006915; GO:0031369; GO:0045948; GO:0060213 0 0 0 PF00575;PF03876; P86179 CHOYP_NEMVEDRAFT_V1G122916.1.1 m.63085 sp CSL3_ONCKE 40.698 86 46 2 10 91 110 194 1.05E-15 72 CSL3_ONCKE reviewed L-rhamnose-binding lectin CSL3 0 Oncorhynchus keta (Chum salmon) (Salmo keta) 195 0 GO:0001674; GO:0005534; GO:0005623; GO:0005737; GO:0033296; GO:0042564; GO:0042803; GO:0060473; GO:1903777 0 0 0 PF02140; Q02369 CHOYP_NDUFB9.2.2 m.58843 sp NDUB9_BOVIN 45.833 120 54 5 19 131 8 123 1.05E-22 92.4 NDUB9_BOVIN reviewed NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit) NDUFB9 UQOR22 Bos taurus (Bovine) 179 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitophagy in response to mitochondrial depolarization [GO:0098779]" GO:0005747; GO:0006120; GO:0008137; GO:0070062; GO:0098779 0 0 0 PF05347; Q09225 CHOYP_BRAFLDRAFT_66615.1.1 m.22226 sp NRF6_CAEEL 29.375 320 207 8 1 306 486 800 1.05E-39 151 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q0E908 CHOYP_BRAFLDRAFT_69505.4.4 m.58014 sp HIL_DROME 26.059 472 305 13 68 521 333 778 1.05E-40 165 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q1ZXD6 CHOYP_BRAFLDRAFT_129004.4.15 m.32167 sp ROCO5_DICDI 26.032 315 183 13 431 740 1335 1604 1.05E-15 86.7 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q2T9T0 CHOYP_BRAFLDRAFT_100695.1.1 m.47761 sp PPR32_BOVIN 35.938 448 244 9 1 442 2 412 1.05E-67 225 PPR32_BOVIN reviewed Protein phosphatase 1 regulatory subunit 32 PPP1R32 Bos taurus (Bovine) 428 0 GO:0019902 0 0 0 PF15691; Q32KL8 CHOYP_LOC100377392.4.4 m.65974 sp TBATA_BOVIN 30.078 256 112 9 47 294 59 255 1.05E-21 99 TBATA_BOVIN reviewed "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)" TBATA SPATIAL Bos taurus (Bovine) 333 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005829; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q3U829 CHOYP_BRAFLDRAFT_117560.1.1 m.18467 sp AP5Z1_MOUSE 33.526 346 225 4 7 349 278 621 1.05E-54 194 AP5Z1_MOUSE reviewed AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) Ap5z1 Kiaa0415 Mus musculus (Mouse) 807 double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031] GO:0000724; GO:0005634; GO:0005654; GO:0005737; GO:0015031; GO:0016197; GO:0044599 0 0 0 PF14764; Q3URR7 CHOYP_ZNF91.2.4 m.10308 sp ZSC10_MOUSE 25.522 431 272 12 447 854 376 780 1.05E-27 124 ZSC10_MOUSE reviewed Zinc finger and SCAN domain-containing protein 10 (Zinc finger protein 206) Zscan10 Zfp206 Mus musculus (Mouse) 782 "negative regulation of transcription, DNA-templated [GO:0045892]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0045892; GO:0046872; GO:0048863 0 0 0 PF02023;PF00096; Q4KLI9 CHOYP_LOC100115921.1.1 m.38061 sp FBXW5_RAT 31.443 194 131 1 11 202 9 202 1.05E-22 99.8 FBXW5_RAT reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) 569 centrosome duplication [GO:0051298]; mitotic nuclear division [GO:0007067]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000151; GO:0005737; GO:0007067; GO:0010824; GO:0016567; GO:0019005; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q4ZJM9 CHOYP_C1QL4.3.10 m.5933 sp C1QL4_MOUSE 35.507 138 70 7 48 179 109 233 1.05E-10 61.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q4ZJM9 CHOYP_GBRAP.1.1 m.37821 sp C1QL4_MOUSE 35.507 138 70 7 48 179 109 233 1.05E-10 61.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5BJP5 CHOYP_TM230.1.1 m.53369 sp TM230_RAT 63.866 119 40 1 21 136 1 119 1.05E-45 147 TM230_RAT reviewed Transmembrane protein 230 Tmem230 Rattus norvegicus (Rat) 120 0 GO:0016021 0 0 0 PF05915; Q5DRB8 CHOYP_BRAFLDRAFT_133692.1.4 m.25185 sp PCDG2_PANTR 30.909 275 164 11 19 276 176 441 1.05E-15 83.2 PCDG2_PANTR reviewed Protocadherin gamma-A2 (PCDH-gamma-A2) PCDHGA2 Pan troglodytes (Chimpanzee) 932 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021 0 0 0 PF00028;PF08266;PF16492;PF15974; Q5E9E1 CHOYP_LOC100162539.1.1 m.29863 sp PDLI1_BOVIN 34.959 369 178 10 11 371 3 317 1.05E-53 183 PDLI1_BOVIN reviewed PDZ and LIM domain protein 1 (Elfin) PDLIM1 Bos taurus (Bovine) 328 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003713; GO:0005667; GO:0005737; GO:0005856; GO:0006355; GO:0008270 0 0 0 PF15936;PF00412;PF00595; Q5F3W5 CHOYP_SUV92.1.1 m.9614 sp SUV92_CHICK 41.35 474 184 8 11 484 10 389 1.05E-114 352 SUV92_CHICK reviewed Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.43) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) SUV39H2 RCJMB04_5f7 Gallus gallus (Chicken) 407 "cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to hypoxia [GO:0071456]; chromatin assembly or disassembly [GO:0006333]; chromatin remodeling [GO:0006338]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000775; GO:0000785; GO:0005634; GO:0006333; GO:0006338; GO:0006351; GO:0007049; GO:0008270; GO:0030154; GO:0046974; GO:0071456 0 0 0 PF00385;PF05033;PF00856; Q5KU26 CHOYP_LOC100674629.1.1 m.29536 sp COL12_HUMAN 32.847 137 79 6 53 183 606 735 1.05E-13 72 COL12_HUMAN reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) (hCL-P1) (Nurse cell scavenger receptor 2) (Scavenger receptor class A member 4) (Scavenger receptor with C-type lectin) COLEC12 CLP1 NSR2 SCARA4 SRCL Homo sapiens (Human) 742 "carbohydrate mediated signaling [GO:0009756]; cellular response to exogenous dsRNA [GO:0071360]; defense response [GO:0006952]; innate immune response [GO:0045087]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; protein homooligomerization [GO:0051260]; receptor-mediated endocytosis [GO:0006898]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005044; GO:0005534; GO:0005581; GO:0005886; GO:0006898; GO:0006910; GO:0006952; GO:0008329; GO:0009756; GO:0016021; GO:0030169; GO:0030666; GO:0034138; GO:0045087; GO:0046872; GO:0051260; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; Q5XHZ6 CHOYP_KLHDB.5.5 m.50793 sp KLHL7_RAT 31.915 188 123 3 106 292 34 217 1.05E-18 89.4 KLHL7_RAT reviewed Kelch-like protein 7 Klhl7 Rattus norvegicus (Rat) 586 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005654; GO:0005730; GO:0005737; GO:0005886; GO:0016567; GO:0031463; GO:0042787; GO:0042803 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q5ZLR5 CHOYP_LOC100742152.1.2 m.4504 sp UCRI_CHICK 51.777 197 94 1 106 302 75 270 1.05E-68 218 UCRI_CHICK reviewed "Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit)" UQCRFS1 RCJMB04_5b19 Gallus gallus (Chicken) 272 0 GO:0005743; GO:0008121; GO:0016021; GO:0043209; GO:0046872; GO:0051537; GO:0070469 0 0 0 PF00355;PF09165;PF02921; Q60431 CHOYP_BRAFLDRAFT_120993.1.2 m.41307 sp CASP3_MESAU 32.903 155 81 4 45 199 34 165 1.05E-14 77.8 CASP3_MESAU reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q68Y52 CHOYP_LOC100708727.1.1 m.55921 sp RAC2_ORYSJ 36.464 181 102 3 7 175 6 185 1.05E-34 124 RAC2_ORYSJ reviewed Rac-like GTP-binding protein 2 (OsRac2) RAC2 Os05g0513800 LOC_Os05g43820 B1155G07.15 OsJ_19185 P0022D06.2 Oryza sativa subsp. japonica (Rice) 214 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0007264; GO:0016020 0 0 0 PF00071; Q69Z28 CHOYP_ATS6.3.3 m.56109 sp ATS16_MOUSE 26.861 618 371 22 35 621 328 895 1.05E-43 172 ATS16_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Adamts16 Kiaa2029 Mus musculus (Mouse) 1222 branching involved in ureteric bud morphogenesis [GO:0001658]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] GO:0001658; GO:0003073; GO:0004222; GO:0005578; GO:0008270; GO:1902017 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q6DCZ7 CHOYP_LOC100122293.1.2 m.2459 sp FBP1L_XENLA 38.64 559 316 8 1 555 1 536 1.05E-130 395 FBP1L_XENLA reviewed Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) fnbp1l toca1 Xenopus laevis (African clawed frog) 543 autophagy [GO:0006914]; endocytosis [GO:0006897] GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006914; GO:0008289; GO:0016023 0 0 0 PF00611;PF00018; Q6DRP4 CHOYP_LOC100375082.1.1 m.38303 sp CCM2_DANRE 35.714 112 64 3 30 141 296 399 1.05E-08 57 CCM2_DANRE reviewed Cerebral cavernous malformations protein 2 homolog (Malcavernin) (Valentine) ccm2 vtn Danio rerio (Zebrafish) (Brachydanio rerio) 455 anterior/posterior axis specification [GO:0009948]; cell-cell junction assembly [GO:0007043]; heart contraction [GO:0060047]; heart development [GO:0007507]; vasculogenesis [GO:0001570] GO:0001570; GO:0005737; GO:0007043; GO:0007507; GO:0009948; GO:0060047 0 0 cd13516; PF16545; Q6P9K8 CHOYP_LOC101165064.1.1 m.44950 sp CSKI1_MOUSE 52.381 63 26 3 1 60 277 338 1.05E-10 61.6 CSKI1_MOUSE reviewed Caskin-1 (CASK-interacting protein 1) Caskin1 Kiaa1306 Mus musculus (Mouse) 1431 signal transduction [GO:0007165] GO:0005737; GO:0007165 0 0 0 PF12796;PF16632;PF00536;PF07653; Q6PBA8 CHOYP_BRAFLDRAFT_245349.1.1 m.45479 sp MNS1_DANRE 54.088 477 218 1 21 497 6 481 1.05E-142 422 MNS1_DANRE reviewed Meiosis-specific nuclear structural protein 1 mns1 zgc:65845 Danio rerio (Zebrafish) (Brachydanio rerio) 486 meiotic cell cycle [GO:0051321] GO:0005634; GO:0031514; GO:0051321 0 0 0 0 Q7M456 CHOYP_LOC100157985.1.1 m.52020 sp RNOY_CRAGI 37.5 200 112 4 36 228 2 195 1.05E-40 142 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q8BJW7 CHOYP_LOC100889179.1.2 m.13206 sp EME1_MOUSE 30.1 598 338 21 58 621 15 566 1.05E-58 209 EME1_MOUSE reviewed Crossover junction endonuclease EME1 (EC 3.1.22.-) Eme1 Mus musculus (Mouse) 570 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to intra-S DNA damage checkpoint signaling [GO:0072429] GO:0000790; GO:0003677; GO:0004519; GO:0005634; GO:0005720; GO:0005730; GO:0005737; GO:0006281; GO:0006310; GO:0046872; GO:0048476; GO:0072429 0 0 0 PF02732; Q8CC21 CHOYP_LOC100122208.1.1 m.58545 sp TTC19_MOUSE 26.389 360 219 9 32 367 3 340 1.05E-29 120 TTC19_MOUSE reviewed "Tetratricopeptide repeat protein 19, mitochondrial (TPR repeat protein 19)" Ttc19 Mus musculus (Mouse) 365 mitochondrial respiratory chain complex III assembly [GO:0034551] GO:0005739; GO:0005743; GO:0034551 0 0 0 PF13374; Q8IWZ3 CHOYP_LOC100641396.18.27 m.53918 sp ANKH1_HUMAN 33.469 245 148 9 399 634 275 513 1.05E-18 94.7 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8IYJ2 CHOYP_BRAFLDRAFT_129914.1.3 m.8213 sp CJ067_HUMAN 26.258 457 281 9 50 490 70 486 1.05E-27 120 CJ067_HUMAN reviewed "Uncharacterized protein C10orf67, mitochondrial" C10orf67 LINC01552 Homo sapiens (Human) 551 0 GO:0005739 0 0 0 PF15821;PF15852; Q8JZM4 CHOYP_LOC100374832.4.5 m.57119 sp DNER_MOUSE 41.333 75 29 2 3209 3283 475 534 1.05E-07 61.6 DNER_MOUSE reviewed Delta and Notch-like epidermal growth factor-related receptor (Brain EGF repeat-containing transmembrane protein) Dner Bet Bret Mus musculus (Mouse) 737 central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; skeletal muscle fiber development [GO:0048741] GO:0005112; GO:0005509; GO:0005769; GO:0005886; GO:0007219; GO:0007220; GO:0007417; GO:0010001; GO:0016021; GO:0030425; GO:0043025; GO:0048741 0 0 0 PF00008;PF12661; Q8NE28 CHOYP_BRAFLDRAFT_76176.1.1 m.55550 sp STKL1_HUMAN 26.707 659 415 18 6 632 25 647 1.05E-51 193 STKL1_HUMAN reviewed Serine/threonine kinase-like domain-containing protein STKLD1 (Serine/threonine kinase-like domain-containing protein 1) (Sugen kinase 071) STKLD1 C9orf96 SGK071 Homo sapiens (Human) 680 0 GO:0004674; GO:0005524 0 0 0 PF00069; Q8R5K5 CHOYP_ISCW_ISCW020956.1.1 m.55533 sp UTP11_RAT 51.383 253 121 2 30 282 3 253 1.05E-81 249 UTP11_RAT reviewed Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein) Utp11 Utp11l Rattus norvegicus (Rat) 253 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] GO:0005730; GO:0006364; GO:0032040; GO:0042274 0 0 0 PF03998; Q8UVC3 CHOYP_INVS.1.6 m.222 sp INVS_CHICK 61.404 285 107 2 71 352 16 300 1.05E-119 374 INVS_CHICK reviewed Inversin INVS Gallus gallus (Chicken) 1106 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005737; GO:0005856; GO:0007275; GO:0016055 0 0 0 PF12796;PF00612; Q90XN9 CHOYP_LOC100376406.1.1 m.10004 sp HMX3B_ORYLA 45.977 261 111 7 20 276 18 252 1.05E-50 172 HMX3B_ORYLA reviewed Homeobox protein HMX3-B (Homeobox protein H6 family member 3-B) (Homeobox protein Nkx-5.1.2) (OlNkx-5.1.2) hmx3b nkx-5.1.2 nkx5-1.2 Oryzias latipes (Japanese rice fish) (Japanese killifish) 290 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007399; GO:0030154; GO:0043565 0 0 0 PF00046; Q92193 CHOYP_KPBB.2.2 m.46103 sp ACT_CRAVI 62.406 133 41 4 4 133 12 138 1.05E-40 139 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q92546 CHOYP_LOC100374952.1.1 m.56404 sp RGP1_HUMAN 45.98 398 195 8 1 385 1 391 1.05E-124 368 RGP1_HUMAN reviewed RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog) RGP1 KIAA0258 Homo sapiens (Human) 391 "negative regulation of cellular protein catabolic process [GO:1903363]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000139; GO:0005829; GO:0016020; GO:0017112; GO:0017137; GO:0032588; GO:0034066; GO:0042147; GO:0043234; GO:0043547; GO:1903363 0 0 0 PF08737; Q99MJ9 CHOYP_DDX21.1.2 m.3695 sp DDX50_MOUSE 53.414 498 192 3 166 662 134 592 1.05E-175 521 DDX50_MOUSE reviewed ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2) Ddx50 Mus musculus (Mouse) 734 RNA secondary structure unwinding [GO:0010501] GO:0004004; GO:0005524; GO:0005730; GO:0005886; GO:0010501; GO:0016020; GO:0044822 0 0 0 PF00270;PF08152;PF00271; Q9BXJ4 CHOYP_NEMVEDRAFT_V1G169195.1.1 m.2477 sp C1QT3_HUMAN 30.519 154 94 6 34 179 92 240 1.05E-07 53.5 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9C1C2 CHOYP_LOC100371136.2.5 m.27653 sp KAPR_COLOR 30.049 203 111 7 37 232 132 310 1.05E-12 73.9 KAPR_COLOR reviewed cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) PKAR RPK1 Cob_09468 Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium) 391 negative regulation of meiotic cell cycle [GO:0051447]; positive regulation of protein export from nucleus [GO:0046827] GO:0005634; GO:0005829; GO:0005952; GO:0008603; GO:0030552; GO:0046827; GO:0051447 0 0 0 PF00027; Q9ESN4 CHOYP_LOC100698649.2.8 m.28161 sp C1QL3_MOUSE 31.579 133 81 3 128 257 127 252 1.05E-08 57.8 C1QL3_MOUSE reviewed Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) 255 regulation of synapse organization [GO:0050807] GO:0005576; GO:0005581; GO:0050807 0 0 0 PF00386;PF01391; Q9ESN6 CHOYP_LOC100374741.2.83 m.671 sp TRIM2_MOUSE 31.148 183 110 9 279 456 536 707 1.05E-13 77 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H0J4 CHOYP_BRAFLDRAFT_119031.2.2 m.50332 sp QRIC2_HUMAN 37.385 436 222 13 602 1015 1247 1653 1.05E-69 259 QRIC2_HUMAN reviewed Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 0 0 0 0 0 PF16043; Q9HCM2 CHOYP_PLXA2.1.3 m.17630 sp PLXA4_HUMAN 27.432 1542 979 53 195 1662 419 1894 1.05E-158 534 PLXA4_HUMAN reviewed Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) 1894 anterior commissure morphogenesis [GO:0021960]; branchiomotor neuron axon guidance [GO:0021785]; chemorepulsion of branchiomotor axon [GO:0021793]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sympathetic nervous system development [GO:0048485]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644] GO:0002116; GO:0005886; GO:0005887; GO:0017154; GO:0021612; GO:0021615; GO:0021637; GO:0021644; GO:0021784; GO:0021785; GO:0021793; GO:0021960; GO:0030334; GO:0048485; GO:0048841; GO:0050923; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q9QZV9 CHOYP_BRAFLDRAFT_92532.1.1 m.11924 sp NXT1_MOUSE 45.865 133 68 1 9 137 5 137 1.05E-43 143 NXT1_MOUSE reviewed NTF2-related export protein 1 Nxt1 Mus musculus (Mouse) 140 mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; RNA export from nucleus [GO:0006405] GO:0005643; GO:0005654; GO:0005737; GO:0006405; GO:0006611; GO:0008536; GO:0016607; GO:0051028 0 0 cd00780; PF02136; Q9V3D2 CHOYP_HEM6.1.1 m.17205 sp HEM6_DROME 64.773 352 121 3 61 409 39 390 1.05E-166 475 HEM6_DROME reviewed Oxygen-dependent coproporphyrinogen-III oxidase (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3) Coprox CG3433 Drosophila melanogaster (Fruit fly) 390 protoporphyrinogen IX biosynthetic process [GO:0006782] GO:0004109; GO:0006782; GO:0042803 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. 0 0 PF01218; Q9WV92 CHOYP_LOC100373842.2.4 m.5139 sp E41L3_MOUSE 57.925 347 140 4 88 433 113 454 1.05E-135 429 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; Q9Z2A5 CHOYP_ATE1.2.3 m.58128 sp ATE1_MOUSE 65.022 223 77 1 8 229 262 484 1.05E-101 307 ATE1_MOUSE reviewed Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) Ate1 Mus musculus (Mouse) 516 protein arginylation [GO:0016598] GO:0004057; GO:0005634; GO:0005737; GO:0016598 0 0 0 PF04377;PF04376; A2AX52 CHOYP_LOC100486063.9.9 m.65186 sp CO6A4_MOUSE 29.63 594 384 15 59 631 33 613 1.06E-69 251 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A4IF63 CHOYP_LOC100370725.5.5 m.61320 sp TRIM2_BOVIN 23.574 263 182 6 301 551 489 744 1.06E-11 71.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6BM72 CHOYP_BM1_57400.6.7 m.65596 sp MEG11_HUMAN 37.281 228 126 11 116 337 219 435 1.06E-27 118 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; A8WGS4 CHOYP_TLCD2.1.1 m.8836 sp TLCD2_DANRE 54.867 226 97 2 20 245 11 231 1.06E-89 268 TLCD2_DANRE reviewed TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) 246 0 GO:0016021 0 0 0 PF03798; B2RU80 CHOYP_LOC586044.1.1 m.60359 sp PTPRB_MOUSE 31.086 801 475 26 886 1656 1239 1992 1.06E-86 318 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; D2GXS7 CHOYP_BRAFLDRAFT_69647.3.5 m.22509 sp TRIM2_AILME 23.413 252 146 5 135 340 494 744 1.06E-10 66.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2KQB0 CHOYP_HHEX.1.2 m.10144 sp HHEX_PATMI 45.588 272 121 7 15 274 2 258 1.06E-61 199 HHEX_PATMI reviewed Hematopoietically-expressed homeobox protein HHEX homolog (AmHEX) (Homeobox protein HEX) (HEX homeodomain transcription factor) hhex hex Patiria miniata (Bat star) (Asterina miniata) 280 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; D3ZAT9 CHOYP_LOC100377010.16.16 m.64693 sp FAXC_RAT 35.565 239 143 6 43 272 98 334 1.06E-46 164 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; D8VNS8 CHOYP_MFAP4.3.3 m.62664 sp FCNV2_CERRY 52.761 163 75 2 113 274 143 304 1.06E-55 186 FCNV2_CERRY reviewed Ryncolin-2 0 Cerberus rynchops (Dog-faced water snake) 347 0 GO:0005576 0 0 0 PF01391;PF00147; O08863 CHOYP_BIRC2.7.13 m.47815 sp BIRC3_MOUSE 33.994 353 202 11 406 733 254 600 1.06E-46 178 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; O15050 CHOYP_LOC100514320.1.2 m.19917 sp TRNK1_HUMAN 54.054 444 185 7 27 470 1144 1568 1.06E-142 455 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O18956 CHOYP_ENTPD1.1.1 m.564 sp ENTP1_BOVIN 36.914 512 297 12 122 622 2 498 1.06E-100 320 ENTP1_BOVIN reviewed Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD antigen CD39) ENTPD1 CD39 Bos taurus (Bovine) 513 0 GO:0005524; GO:0016021; GO:0016787 0 0 0 PF01150; O35130 CHOYP_NEMVEDRAFT_V1G166546.1.1 m.10454 sp NEP1_MOUSE 72.549 204 56 0 25 228 41 244 1.06E-109 318 NEP1_MOUSE reviewed Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1) Emg1 C2f Grcc2f Mus musculus (Mouse) 244 "blastocyst development [GO:0001824]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nucleologenesis [GO:0017126]; rRNA base methylation [GO:0070475]" GO:0000462; GO:0001824; GO:0005730; GO:0017126; GO:0019843; GO:0032040; GO:0044822; GO:0070037; GO:0070475 0 0 0 PF03587; O55227 CHOYP_UNC50.1.1 m.65758 sp UNC50_RAT 61.776 259 97 2 7 264 1 258 1.06E-112 327 UNC50_RAT reviewed Protein unc-50 homolog (Uncoordinated-like protein) Unc50 Uncl Rattus norvegicus (Rat) 259 cell surface receptor signaling pathway [GO:0007166]; protein transport [GO:0015031]; transport [GO:0006810] GO:0000139; GO:0003723; GO:0005637; GO:0006810; GO:0007166; GO:0015031; GO:0030173 0 0 0 PF05216; O70201 CHOYP_BIRC5.1.1 m.28704 sp BIRC5_MOUSE 51.163 129 62 1 10 138 10 137 1.06E-42 140 BIRC5_MOUSE reviewed Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) (TIAP) Birc5 Api4 Iap4 Mus musculus (Mouse) 140 "cell division [GO:0051301]; chromosome segregation [GO:0007059]; cytokinesis [GO:0000910]; establishment of chromosome localization [GO:0051303]; G2/M transition of mitotic cell cycle [GO:0000086]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of mitotic cell cycle [GO:0045931]; protein complex localization [GO:0031503]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of mitotic cell cycle [GO:0007346]; regulation of signal transduction [GO:0009966]; regulation of type B pancreatic cell proliferation [GO:0061469]; spindle checkpoint [GO:0031577]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0000226; GO:0000228; GO:0000775; GO:0000777; GO:0000910; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005814; GO:0005829; GO:0005876; GO:0005881; GO:0006351; GO:0006468; GO:0007059; GO:0007346; GO:0008017; GO:0008270; GO:0008536; GO:0009966; GO:0015631; GO:0019899; GO:0030496; GO:0031021; GO:0031503; GO:0031536; GO:0031577; GO:0032133; GO:0042802; GO:0042803; GO:0043027; GO:0043066; GO:0043154; GO:0043524; GO:0045892; GO:0045931; GO:0048037; GO:0051087; GO:0051301; GO:0051303; GO:0061178; GO:0061469; GO:0090307; GO:1990001 0 0 0 PF00653; O75840 CHOYP_LOC101272716.1.1 m.53145 sp KLF7_HUMAN 42.47 332 160 5 1 332 1 301 1.06E-75 238 KLF7_HUMAN reviewed Krueppel-like factor 7 (Ubiquitous krueppel-like factor) KLF7 UKLF Homo sapiens (Human) 302 "axon guidance [GO:0007411]; dendrite morphogenesis [GO:0048813]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0006351; GO:0006357; GO:0007411; GO:0008270; GO:0045893; GO:0048813 0 0 0 0 O75970 CHOYP_MPDZ.1.3 m.1739 sp MPDZ_HUMAN 51.63 184 79 5 1 183 1895 2069 1.06E-50 178 MPDZ_HUMAN reviewed Multiple PDZ domain protein (Multi-PDZ domain protein 1) MPDZ MUPP1 Homo sapiens (Human) 2070 cell adhesion [GO:0007155]; myelination [GO:0042552]; viral process [GO:0016032] GO:0005737; GO:0005923; GO:0007155; GO:0008022; GO:0014069; GO:0016032; GO:0016324; GO:0016327; GO:0030425; GO:0031410; GO:0042552; GO:0043220; GO:0045211 0 0 0 PF09045;PF16667;PF00595; O76095 CHOYP_PHUM_PHUM037820.1.1 m.62220 sp JTB_HUMAN 32.584 89 57 3 64 151 59 145 1.06E-08 53.9 JTB_HUMAN reviewed Protein JTB (Jumping translocation breakpoint protein) (Prostate androgen-regulated protein) (PAR protein) JTB HSPC222 Homo sapiens (Human) 146 apoptotic mitochondrial changes [GO:0008637]; cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; positive regulation of protein kinase activity [GO:0045860]; regulation of cell proliferation [GO:0042127] GO:0000910; GO:0005737; GO:0005739; GO:0005815; GO:0005819; GO:0005887; GO:0007067; GO:0008637; GO:0016020; GO:0019901; GO:0030496; GO:0042127; GO:0045860 0 0 0 PF05439; O93430 CHOYP_GLUCL.1.1 m.60810 sp GLRA1_DANRE 23.35 394 257 11 34 399 54 430 1.06E-30 125 GLRA1_DANRE reviewed Glycine receptor subunit alphaZ1 glra1 Danio rerio (Zebrafish) (Brachydanio rerio) 444 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; ion transport [GO:0006811]; neuropeptide signaling pathway [GO:0007218]; protein homooligomerization [GO:0051260]; regulation of neuron differentiation [GO:0045664]; response to amino acid [GO:0043200]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0006811; GO:0007218; GO:0007417; GO:0008270; GO:0016021; GO:0016594; GO:0016934; GO:0022824; GO:0030054; GO:0030425; GO:0034707; GO:0043200; GO:0043204; GO:0045211; GO:0045664; GO:0051260; GO:0060012; GO:0071230; GO:0071294; GO:0071361 0 0 0 PF02931;PF02932; O94581 CHOYP_CC1G_13336.1.3 m.23079 sp COX12_SCHPO 62.857 70 26 0 52 121 15 84 1.06E-25 95.5 COX12_SCHPO reviewed Cytochrome c oxidase subunit 6B (Cytochrome c oxidase polypeptide VIb) cox12 SPCC1442.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 86 0 GO:0004129; GO:0005634; GO:0005739; GO:0005829 0 0 0 PF02297; O95236 CHOYP_LOC798813.1.1 m.31862 sp APOL3_HUMAN 32.99 97 65 0 1178 1274 177 273 1.06E-07 59.7 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P00491 CHOYP_LOC100872507.1.1 m.21152 sp PNPH_HUMAN 53.419 234 109 0 37 270 3 236 1.06E-90 273 PNPH_HUMAN reviewed Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Homo sapiens (Human) 289 immune response [GO:0006955]; inosine catabolic process [GO:0006148]; interleukin-2 secretion [GO:0070970]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of T cell proliferation [GO:0042102]; purine-containing compound salvage [GO:0043101]; purine nucleotide catabolic process [GO:0006195]; response to drug [GO:0042493]; urate biosynthetic process [GO:0034418] GO:0001882; GO:0002060; GO:0004731; GO:0005622; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0006139; GO:0006148; GO:0006195; GO:0006738; GO:0006955; GO:0008144; GO:0034356; GO:0034418; GO:0042102; GO:0042301; GO:0042493; GO:0043101; GO:0046638; GO:0070062; GO:0070970 PATHWAY: Purine metabolism; purine nucleoside salvage. 0 0 PF01048; P02711 CHOYP_ACHG.1.1 m.20125 sp ACHA_TORMA 28.308 325 219 7 3 321 12 328 1.06E-31 128 ACHA_TORMA reviewed Acetylcholine receptor subunit alpha CHRNA1 Torpedo marmorata (Marbled electric ray) 461 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; P07572 CHOYP_LOC100494344.3.3 m.49315 sp POL_MPMV 21.875 320 202 10 7 313 47 331 1.06E-07 58.2 POL_MPMV reviewed Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) 867 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P0C6B8 CHOYP_BRAFLDRAFT_103544.1.1 m.38439 sp SVEP1_RAT 26.703 1835 1208 50 335 2047 1641 3460 1.06E-149 528 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P10079 CHOYP_LOC100632098.13.13 m.61716 sp FBP1_STRPU 53.027 479 225 0 1 479 205 683 1.06E-160 485 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11678 CHOYP_BRAFLDRAFT_125550.3.5 m.38081 sp PERE_HUMAN 34.93 647 318 17 135 756 145 713 1.06E-111 358 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P16157 CHOYP_AFUA_1G01020.10.50 m.21390 sp ANK1_HUMAN 35.031 648 390 3 2 619 97 743 1.06E-97 331 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17133 CHOYP_COQ5.1.1 m.29789 sp RU17_DROME 60.185 108 43 0 1 108 1 108 1.06E-29 114 RU17_DROME reviewed U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) snRNP-U1-70K snRNP27D snRNP70K CG8749 Drosophila melanogaster (Fruit fly) 448 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; neurogenesis [GO:0022008]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]" GO:0000166; GO:0000243; GO:0000381; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005681; GO:0005685; GO:0007052; GO:0016607; GO:0022008; GO:0030619; GO:0043484; GO:0048025; GO:0071004; GO:0071011; GO:0071013 0 0 0 PF00076;PF12220; P17644 CHOYP_DVIR_GJ23817.1.1 m.1090 sp ACH2_DROME 55.285 246 101 3 45 290 56 292 1.06E-92 288 ACH2_DROME reviewed Acetylcholine receptor subunit alpha-like 2 (Nicotinic acetylcholine receptor alpha 2) nAChRalpha2 Acr96Ab AcrE nAcRalpha-96Ab sad CG6844 Drosophila melanogaster (Fruit fly) 576 "cation transport [GO:0006812]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0006812; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211 0 0 0 PF02931;PF02932; P18172 CHOYP_LOC100877554.1.2 m.29626 sp DHGL_DROPS 38.808 621 327 13 5 604 26 614 1.06E-129 397 DHGL_DROPS reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) 625 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; P18173 CHOYP_LOC100118063.4.4 m.64613 sp DHGL_DROME 39.414 614 313 14 5 594 26 604 1.06E-127 392 DHGL_DROME reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) 625 glucose metabolic process [GO:0006006]; pupal chitin-based cuticle development [GO:0008364]; sensory perception of pain [GO:0019233]; sperm storage [GO:0046693] GO:0005576; GO:0006006; GO:0008364; GO:0016614; GO:0019233; GO:0046693; GO:0050660 0 0 0 PF05199;PF00732; P22105 CHOYP_LOC100176721.6.6 m.66056 sp TENX_HUMAN 31.059 557 239 27 20 546 191 632 1.06E-25 116 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P24156 CHOYP_EF2.1.5 m.1541 sp L2CC_DROME 72.862 269 73 0 2 270 3 271 1.06E-144 409 L2CC_DROME reviewed Protein l(2)37Cc l(2)37Cc CG10691 Drosophila melanogaster (Fruit fly) 276 cellular response to hypoxia [GO:0071456]; multicellular organism development [GO:0007275]; sensory perception of pain [GO:0019233] GO:0005737; GO:0005739; GO:0005811; GO:0005875; GO:0007275; GO:0016020; GO:0019233; GO:0071456 0 0 cd03401; PF01145; P24540 CHOYP_LOC101065571.1.2 m.36430 sp ACYP1_PIG 43.956 91 51 0 6 96 9 99 1.06E-23 89.7 ACYP1_PIG reviewed "Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1)" ACYP1 ACYPE Sus scrofa (Pig) 101 0 GO:0003998 0 0 0 PF00708; P41386 CHOYP_TBB2.2.2 m.53003 sp TBB_HALDI 77.586 116 24 2 45 160 10 123 1.06E-43 151 TBB_HALDI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Haliotis discus (Abalone) (Nordotis discus) 341 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P42674 CHOYP_NAS35.1.1 m.48665 sp BP10_PARLI 32.026 306 173 9 138 428 101 386 1.06E-38 150 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P43699 CHOYP_NKX2-1.1.1 m.27188 sp NKX21_HUMAN 51.418 282 102 10 1 259 1 270 1.06E-65 215 NKX21_HUMAN reviewed Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP) NKX2-1 NKX2A TITF1 TTF1 Homo sapiens (Human) 371 "anatomical structure formation involved in morphogenesis [GO:0048646]; axon guidance [GO:0007411]; brain development [GO:0007420]; cerebral cortex cell migration [GO:0021795]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; Clara cell differentiation [GO:0060486]; developmental induction [GO:0031128]; development of primary female sexual characteristics [GO:0046545]; endoderm development [GO:0007492]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain neuron fate commitment [GO:0021877]; globus pallidus development [GO:0021759]; hippocampus development [GO:0021766]; hyperosmotic salinity response [GO:0042538]; Leydig cell differentiation [GO:0033327]; locomotory behavior [GO:0007626]; lung development [GO:0030324]; lung saccule development [GO:0060430]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron migration [GO:0001764]; oligodendrocyte differentiation [GO:0048709]; phospholipid metabolic process [GO:0006644]; pituitary gland development [GO:0021983]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of blood volume by renin-angiotensin [GO:0002016]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; rhythmic process [GO:0048511]; thyroid gland development [GO:0030878]; transcription, DNA-templated [GO:0006351]; Type II pneumocyte differentiation [GO:0060510]" GO:0000122; GO:0000977; GO:0001012; GO:0001047; GO:0001161; GO:0001764; GO:0002016; GO:0003677; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0005667; GO:0006351; GO:0006644; GO:0007411; GO:0007420; GO:0007492; GO:0007626; GO:0007631; GO:0009725; GO:0010628; GO:0010719; GO:0019899; GO:0021759; GO:0021766; GO:0021795; GO:0021798; GO:0021877; GO:0021892; GO:0021983; GO:0030324; GO:0030336; GO:0030512; GO:0030878; GO:0030900; GO:0031128; GO:0032496; GO:0033327; GO:0042538; GO:0042753; GO:0044212; GO:0044213; GO:0045471; GO:0045892; GO:0045893; GO:0045944; GO:0046545; GO:0048511; GO:0048646; GO:0048709; GO:0060430; GO:0060441; GO:0060486; GO:0060510 0 0 0 PF00046; P49641 CHOYP_LOC100180083.1.1 m.6231 sp MA2A2_HUMAN 32.124 386 241 9 10 383 648 1024 1.06E-46 174 MA2A2_HUMAN reviewed "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A2 MANA2X Homo sapiens (Human) 1150 mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein deglycosylation [GO:0006517] GO:0000139; GO:0004559; GO:0004572; GO:0006013; GO:0006491; GO:0006517; GO:0008270; GO:0016021; GO:0016799; GO:0030246 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09261;PF01074;PF07748; P51449 CHOYP_RORA.2.2 m.59320 sp RORG_HUMAN 25.532 470 276 15 78 526 30 446 1.06E-24 111 RORG_HUMAN reviewed Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) RORC NR1F3 RORG RZRG Homo sapiens (Human) 518 "adipose tissue development [GO:0060612]; cellular response to sterol [GO:0036315]; circadian regulation of gene expression [GO:0032922]; lymph node development [GO:0048535]; negative regulation of thymocyte apoptotic process [GO:0070244]; Peyer's patch development [GO:0048541]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; regulation of glucose metabolic process [GO:0010906]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription involved in cell fate commitment [GO:0060850]; T-helper 17 cell differentiation [GO:0072539]; T-helper cell differentiation [GO:0042093]; transcription initiation from RNA polymerase II promoter [GO:0006367]; xenobiotic metabolic process [GO:0006805]" GO:0003677; GO:0003700; GO:0003707; GO:0004879; GO:0005634; GO:0005654; GO:0005730; GO:0006367; GO:0006805; GO:0008142; GO:0008270; GO:0010906; GO:0019218; GO:0032922; GO:0036315; GO:0042093; GO:0042753; GO:0043231; GO:0043565; GO:0045598; GO:0045893; GO:0048535; GO:0048541; GO:0060612; GO:0060850; GO:0070244; GO:0072539; GO:0098531 0 0 0 PF00104;PF00105; P59111 CHOYP_KCNH8.2.2 m.52435 sp KCNH8_MOUSE 57.389 406 151 5 1 390 310 709 1.06E-146 448 KCNH8_MOUSE reviewed Potassium voltage-gated channel subfamily H member 8 (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Voltage-gated potassium channel subunit Kv12.1) Kcnh8 Mus musculus (Mouse) 1102 regulation of membrane potential [GO:0042391] GO:0000155; GO:0005249; GO:0005622; GO:0005887; GO:0042391 0 0 0 PF00027;PF00520;PF13426; P62255 CHOYP_LOC100691486.1.1 m.24965 sp UB2G1_RAT 74.699 166 41 1 1 165 1 166 1.06E-89 261 UB2G1_RAT reviewed "Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]" Ube2g1 Ubc7 Ube2g Rattus norvegicus (Rat) 170 protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0004842; GO:0005524; GO:0005737; GO:0006511; GO:0016567; GO:0031625; GO:0061630; GO:0061631; GO:0070062; GO:0070534; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; P70031 CHOYP_LOC100890822.1.2 m.23399 sp CCKAR_XENLA 20.213 376 259 10 27 395 68 409 1.06E-08 60.5 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q01196 CHOYP_PHUM_PHUM333320.1.1 m.31040 sp RUNX1_HUMAN 65.19 158 38 2 59 200 21 177 1.06E-65 211 RUNX1_HUMAN reviewed Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) RUNX1 AML1 CBFA2 Homo sapiens (Human) 453 "chondrocyte differentiation [GO:0002062]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; myeloid cell differentiation [GO:0030099]; negative regulation of granulocyte differentiation [GO:0030853]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of angiogenesis [GO:0045766]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000975; GO:0000977; GO:0001047; GO:0001228; GO:0001503; GO:0002062; GO:0003677; GO:0003700; GO:0005509; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0008134; GO:0030097; GO:0030099; GO:0030853; GO:0030854; GO:0032743; GO:0042803; GO:0043231; GO:0045766; GO:0045893; GO:0045944; GO:0046982; GO:0048935; GO:0071425 0 0 0 PF00853;PF08504; Q04831 CHOYP_GLNA.4.5 m.19941 sp GLNA_PANAR 64.532 203 66 2 1 197 1 203 1.06E-93 288 GLNA_PANAR reviewed Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) 0 Panulirus argus (Caribbean spiny lobster) (Palinurus argus) 361 glutamine biosynthetic process [GO:0006542] GO:0004356; GO:0005524; GO:0005737; GO:0006542 0 0 0 PF00120;PF03951; Q06852 CHOYP_RD23B.1.1 m.38953 sp SLAP1_CLOTH 53.416 161 49 12 2 138 1443 1601 1.06E-07 57.4 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q06852 CHOYP_SSPO.8.14 m.32069 sp SLAP1_CLOTH 51.756 427 135 30 1 368 1553 1967 1.06E-28 129 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0VBV7 CHOYP_BRAFLDRAFT_85465.1.1 m.8017 sp CE126_MOUSE 28.52 277 137 10 4 256 35 274 1.06E-11 73.2 CE126_MOUSE reviewed Centrosomal protein of 126 kDa Cep126 Kiaa1377 Mus musculus (Mouse) 1103 cilium assembly [GO:0042384]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle organization [GO:0007052]; nonmotile primary cilium assembly [GO:0035058] GO:0005737; GO:0005813; GO:0007052; GO:0030496; GO:0031122; GO:0035058; GO:0042384; GO:0097546 0 0 0 PF15352; Q0ZM14 CHOYP_FAT4.4.10 m.16917 sp PCD15_CHICK 30.769 429 253 19 166 579 615 1014 1.06E-28 125 PCD15_CHICK reviewed Protocadherin-15 Pcdh15 Gallus gallus (Chicken) 1899 actin filament bundle assembly [GO:0051017]; adult walking behavior [GO:0007628]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in equilibrioception [GO:0050973]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of an epithelium [GO:0002009]; multicellular organism growth [GO:0035264]; nonmotile primary cilium assembly [GO:0035058]; righting reflex [GO:0060013]; startle response [GO:0001964]; visual perception [GO:0007601] GO:0001750; GO:0001964; GO:0002009; GO:0005509; GO:0005737; GO:0005886; GO:0007156; GO:0007601; GO:0007628; GO:0016021; GO:0032420; GO:0035058; GO:0035264; GO:0050910; GO:0050973; GO:0051017; GO:0060013; GO:0060088 0 0 0 PF00028; Q13310 CHOYP_PABP4.2.6 m.22636 sp PABP4_HUMAN 52.358 212 82 4 4 206 431 632 1.06E-45 163 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q1LXI5 CHOYP_RM54.1.1 m.50049 sp RM54_DANRE 46.479 71 32 2 47 113 60 128 1.06E-15 71.2 RM54_DANRE reviewed "39S ribosomal protein L54, mitochondrial (L54mt) (MRP-L54)" mrpl54 si:dkeyp-70f9.5 Danio rerio (Zebrafish) (Brachydanio rerio) 135 0 GO:0005739; GO:0005840 0 0 0 PF08561; Q25145 CHOYP_TPM.15.19 m.50851 sp TPM_HALRU 69.784 278 84 0 1 278 1 278 1.06E-118 344 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q2VPU4 CHOYP_MLXIP.1.3 m.5059 sp MLXIP_MOUSE 39.437 71 43 0 1 71 838 908 1.06E-07 55.5 MLXIP_MOUSE reviewed MLX-interacting protein (Transcriptional activator MondoA) Mlxip Mir Mus musculus (Mouse) 917 "nucleocytoplasmic transport [GO:0006913]; regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter [GO:1900402]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000989; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0005741; GO:0006351; GO:0006357; GO:0006913; GO:1900402 0 0 0 PF00010; Q53G44 CHOYP_LOC100377780.1.11 m.12851 sp IF44L_HUMAN 32.517 449 257 8 62 501 24 435 1.06E-54 193 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5BLE8 CHOYP_NEMVEDRAFT_V1G183264.2.2 m.62234 sp RETST_DANRE 40.893 291 165 3 26 316 8 291 1.06E-75 246 RETST_DANRE reviewed "Putative all-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat)" retsat zgc:113107 Danio rerio (Zebrafish) (Brachydanio rerio) 607 0 GO:0016020; GO:0051786 0 0 0 PF01593; Q5R7R6 CHOYP_LOC100375074.1.1 m.42145 sp COG4_PONAB 53.676 272 118 3 6 272 513 781 1.06E-98 309 COG4_PONAB reviewed Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 785 protein transport [GO:0015031] GO:0000139; GO:0015031 0 0 0 PF08318; Q5RHP9 CHOYP_LOC100179357.6.6 m.49893 sp ERIC3_HUMAN 33.694 555 262 19 1 488 1 516 1.06E-69 263 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q5ZKK5 CHOYP_LOC100366442.3.4 m.40691 sp ODFP2_CHICK 39.29 817 436 10 9 778 6 809 1.06E-173 523 ODFP2_CHICK reviewed Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2) ODF2 RCJMB04_10e12 Gallus gallus (Chicken) 822 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0005815; GO:0005874; GO:0005929; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q60803 CHOYP_TRAF3.1.4 m.13457 sp TRAF3_MOUSE 43.199 544 286 9 20 557 41 567 1.06E-151 449 TRAF3_MOUSE reviewed TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) 567 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; toll-like receptor signaling pathway [GO:0002224]; Toll signaling pathway [GO:0008063]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005768; GO:0006915; GO:0008063; GO:0008270; GO:0009898; GO:0016874; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032088; GO:0032648; GO:0033209; GO:0035631; GO:0042981; GO:0045087; GO:0050688 0 0 0 PF02176; Q66H10 CHOYP_FBX39.1.1 m.48063 sp FBX39_RAT 30.28 393 262 9 23 405 12 402 1.06E-54 191 FBX39_RAT reviewed F-box only protein 39 Fbxo39 Rattus norvegicus (Rat) 443 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0019005; GO:0031146 0 0 0 PF12937; Q6DHN0 CHOYP_LOC101168321.1.1 m.8922 sp TMM53_DANRE 34.694 294 165 9 3 288 1 275 1.06E-49 169 TMM53_DANRE reviewed Transmembrane protein 53 tmem53 zgc:92204 Danio rerio (Zebrafish) (Brachydanio rerio) 281 0 GO:0016021 0 0 0 PF05705; Q6GM59 CHOYP_LOC101064201.1.1 m.31573 sp MOT12_XENLA 26.471 408 249 11 10 385 67 455 1.06E-29 122 MOT12_XENLA reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) 460 creatine transmembrane transport [GO:1902598] GO:0005308; GO:0005887; GO:0015293; GO:1902598 0 0 cd06174; PF07690; Q6P2K3 CHOYP_NEMVEDRAFT_V1G238528.1.1 m.16526 sp CC067_MOUSE 37.984 387 196 11 1 373 1 357 1.06E-69 248 CC067_MOUSE reviewed Uncharacterized protein C3orf67 homolog 0 Mus musculus (Mouse) 674 0 0 0 0 0 PF05018; Q6PFY8 CHOYP_BRAFLDRAFT_75787.5.5 m.65485 sp TRI45_MOUSE 29.231 195 119 4 15 197 135 322 1.06E-12 73.2 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6Q899 CHOYP_IFIH1.2.14 m.12589 sp DDX58_MOUSE 28.634 915 588 28 222 1108 20 897 1.06E-89 313 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6V0I7 CHOYP_PCD15.1.1 m.50352 sp FAT4_HUMAN 29.454 421 261 13 140 546 2982 3380 1.06E-28 125 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q6ZRF8 CHOYP_BRAFLDRAFT_117187.3.4 m.17858 sp RN207_HUMAN 23.214 224 154 7 44 265 103 310 1.06E-11 69.3 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_LOC100368204.2.3 m.32455 sp RN207_HUMAN 26.794 209 130 10 16 218 103 294 1.06E-12 71.6 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q75WF2 CHOYP_DNA2.5.5 m.63706 sp DNA2_ACAPL 32.581 310 184 10 1 292 7 309 1.06E-40 147 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q7KRY7 CHOYP_ISCW_ISCW019590.1.1 m.30707 sp LAP4_DROME 54.438 338 141 4 2 336 154 481 1.06E-99 358 LAP4_DROME reviewed Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) 1851 "anterior/posterior axis specification, follicular epithelium [GO:0030714]; asymmetric protein localization [GO:0008105]; cell fate commitment involved in pattern specification [GO:0060581]; cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; compound eye development [GO:0048749]; dorsal closure [GO:0007391]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; Malpighian tubule development [GO:0072002]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; morphogenesis of follicular epithelium [GO:0016333]; morphogenesis of larval imaginal disc epithelium [GO:0016335]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; olfactory behavior [GO:0042048]; ovarian follicle cell development [GO:0030707]; pole plasm protein localization [GO:0007318]; positive regulation of heart contraction [GO:0045823]; R3/R4 cell fate commitment [GO:0007464]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of JAK-STAT cascade [GO:0046425]; regulation of Notch signaling pathway [GO:0008593]; regulation of synapse structure or activity [GO:0050803]; sensory perception of smell [GO:0007608]; septate junction assembly [GO:0019991]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; wing disc morphogenesis [GO:0007472]; zonula adherens assembly [GO:0045186]" GO:0000122; GO:0000902; GO:0001708; GO:0001737; GO:0001738; GO:0005179; GO:0005576; GO:0005918; GO:0005923; GO:0007318; GO:0007391; GO:0007464; GO:0007472; GO:0007608; GO:0008105; GO:0008283; GO:0008285; GO:0008593; GO:0016323; GO:0016327; GO:0016328; GO:0016331; GO:0016332; GO:0016333; GO:0016334; GO:0016335; GO:0016336; GO:0019991; GO:0030100; GO:0030707; GO:0030714; GO:0031594; GO:0035088; GO:0042048; GO:0042058; GO:0042067; GO:0045169; GO:0045186; GO:0045197; GO:0045198; GO:0045571; GO:0045823; GO:0046425; GO:0048749; GO:0048863; GO:0050680; GO:0050803; GO:0051726; GO:0060581; GO:0072002; GO:0072089 0 0 0 PF13855;PF00595; Q7TMA4 CHOYP_LOC100570116.1.1 m.23743 sp FFAR4_MOUSE 32.479 351 223 8 11 352 12 357 1.06E-35 136 FFAR4_MOUSE reviewed Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor GT01) (Omega-3 fatty acid receptor 1) Ffar4 Gpr120 O3far1 Mus musculus (Mouse) 361 fat cell differentiation [GO:0045444]; G-protein coupled receptor signaling pathway [GO:0007186]; hormone secretion [GO:0046879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of inflammatory response [GO:0050728]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of glucose transport [GO:0010827] GO:0004930; GO:0005504; GO:0005886; GO:0005887; GO:0007186; GO:0008527; GO:0010827; GO:0030139; GO:0043066; GO:0045444; GO:0046879; GO:0050710; GO:0050728; GO:0070374 0 0 0 PF00001; Q8BGC3 CHOYP_LOC100745107.1.3 m.15040 sp MOT12_MOUSE 31.155 459 261 9 13 464 5 415 1.06E-64 219 MOT12_MOUSE reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) Slc16a12 Mct12 Mus musculus (Mouse) 486 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q8K0U4 CHOYP_HS12A.12.33 m.39763 sp HS12A_MOUSE 30.899 356 196 8 55 363 57 409 1.06E-41 159 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K396 CHOYP_LOC100376369.1.1 m.18334 sp MND1_MOUSE 60.976 205 80 0 1 205 1 205 1.06E-87 259 MND1_MOUSE reviewed Meiotic nuclear division protein 1 homolog Mnd1 Mus musculus (Mouse) 205 DNA recombination [GO:0006310]; meiotic cell cycle [GO:0051321] GO:0003677; GO:0005634; GO:0006310; GO:0051321 0 0 0 PF03962; Q8N3Y7 CHOYP_RDH10.1.1 m.2974 sp RDHE2_HUMAN 48.736 277 142 0 41 317 30 306 1.06E-93 283 RDHE2_HUMAN reviewed Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5) SDR16C5 RDHE2 Homo sapiens (Human) 309 detection of light stimulus involved in visual perception [GO:0050908]; keratinocyte proliferation [GO:0043616]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572] GO:0004745; GO:0005789; GO:0016021; GO:0042572; GO:0042574; GO:0043616; GO:0050908 PATHWAY: Cofactor metabolism; retinol metabolism. 0 0 PF00106; Q8NCC3 CHOYP_BRAFLDRAFT_230181.1.1 m.61583 sp PAG15_HUMAN 48.404 376 191 2 39 414 39 411 1.06E-132 390 PAG15_HUMAN reviewed Group XV phospholipase A2 (EC 2.3.1.-) (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (Lysophospholipase 3) (Lysosomal phospholipase A2) (LPLA2) PLA2G15 LYPLA3 UNQ341/PRO540 Homo sapiens (Human) 412 ceramide metabolic process [GO:0006672]; fatty acid catabolic process [GO:0009062]; glycerophospholipid metabolic process [GO:0006650]; phosphatidylcholine catabolic process [GO:0034638]; phosphatidylethanolamine catabolic process [GO:0046338] GO:0004622; GO:0005543; GO:0005615; GO:0005739; GO:0005764; GO:0006650; GO:0006672; GO:0008374; GO:0009062; GO:0016020; GO:0034638; GO:0046338; GO:0047499; GO:0070062 0 0 0 PF02450; Q8R0M8 CHOYP_LOC100883709.1.2 m.31561 sp MOT5_MOUSE 23.471 507 345 8 30 535 30 494 1.06E-36 145 MOT5_MOUSE reviewed Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) 500 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; Q8R412 CHOYP_LOC100372166.1.1 m.53441 sp IF27A_MOUSE 61.765 68 23 1 108 175 12 76 1.06E-12 66.6 IF27A_MOUSE reviewed Interferon alpha-inducible protein 27-like protein 2A (Interferon-stimulated gene 12 protein) (ISG12) Ifi27l2a Ifi27 Isg12 Mus musculus (Mouse) 90 aging [GO:0007568]; response to virus [GO:0009615] GO:0007568; GO:0009615; GO:0016021 0 0 0 PF06140; Q8UVC3 CHOYP_LOC100367361.1.1 m.35994 sp INVS_CHICK 29.577 284 178 7 120 395 26 295 1.06E-23 110 INVS_CHICK reviewed Inversin INVS Gallus gallus (Chicken) 1106 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005737; GO:0005856; GO:0007275; GO:0016055 0 0 0 PF12796;PF00612; Q92733 CHOYP_PRCC.1.2 m.29269 sp PRCC_HUMAN 47.191 89 43 4 110 195 136 223 1.06E-09 60.5 PRCC_HUMAN reviewed Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) PRCC TPRC Homo sapiens (Human) 491 mitotic cell cycle checkpoint [GO:0007093] GO:0005634; GO:0007093 0 0 0 PF10253; Q96DB2 CHOYP_HDA11.1.1 m.22871 sp HDA11_HUMAN 67.341 346 107 2 12 351 2 347 1.06E-170 483 HDA11_HUMAN reviewed Histone deacetylase 11 (HD11) (EC 3.5.1.98) HDAC11 Homo sapiens (Human) 347 "chromatin modification [GO:0016568]; histone deacetylation [GO:0016575]; oligodendrocyte development [GO:0014003]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0004407; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0008134; GO:0014003; GO:0016568; GO:0016575; GO:0032041; GO:0070062 0 0 0 PF00850; Q96KE9 CHOYP_TSP_07884.1.1 m.41175 sp BTBD6_HUMAN 28.287 251 173 3 9 252 62 312 1.06E-26 116 BTBD6_HUMAN reviewed BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) 485 neurogenesis [GO:0022008]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of proteolysis [GO:0030162] GO:0000932; GO:0005829; GO:0019005; GO:0022008; GO:0030162; GO:0031625; GO:0042787; GO:0043161 0 0 0 PF07707;PF00651;PF08005; Q96WV6 CHOYP_contig_005392 m.6119 sp YHU2_SCHPO 33.077 260 158 3 1 257 946 1192 1.06E-06 53.1 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q98943 CHOYP_LOC100888891.2.2 m.19918 sp CASP2_CHICK 30.833 120 83 0 933 1052 3 122 1.06E-07 59.3 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q99315 CHOYP_LOC101154902.1.1 m.22178 sp YG31B_YEAST 25.389 386 259 7 158 535 597 961 1.06E-23 109 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9BTV4 CHOYP_BRAFLDRAFT_57622.1.2 m.629 sp TMM43_HUMAN 43.57 381 213 2 37 416 14 393 1.06E-106 323 TMM43_HUMAN reviewed Transmembrane protein 43 (Protein LUMA) TMEM43 UNQ2564/PRO6244 Homo sapiens (Human) 400 nuclear membrane organization [GO:0071763] GO:0005639; GO:0005788; GO:0005794; GO:0071763 0 0 0 PF07787; Q9BXA9 CHOYP_LOC100642338.1.1 m.22484 sp SALL3_HUMAN 49.867 375 145 12 391 748 413 761 1.06E-93 334 SALL3_HUMAN reviewed Sal-like protein 3 (Zinc finger protein 796) (Zinc finger protein SALL3) (hSALL3) SALL3 ZNF796 Homo sapiens (Human) 1300 "forelimb morphogenesis [GO:0035136]; hindlimb morphogenesis [GO:0035137]; negative regulation of smoothened signaling pathway [GO:0045879]; neurogenesis [GO:0022008]; olfactory bulb interneuron development [GO:0021891]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003700; GO:0005634; GO:0006355; GO:0006366; GO:0007165; GO:0021891; GO:0022008; GO:0035136; GO:0035137; GO:0043565; GO:0044212; GO:0045879; GO:0046872 0 0 0 0 Q9CYH6 CHOYP_RHG17.1.2 m.32099 sp RRS1_MOUSE 51.077 325 149 7 5 323 6 326 1.06E-104 314 RRS1_MOUSE reviewed Ribosome biogenesis regulatory protein homolog Rrs1 Rrr MNCb-2643 Mus musculus (Mouse) 365 "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic metaphase plate congression [GO:0007080]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]" GO:0000055; GO:0000447; GO:0000794; GO:0002244; GO:0005634; GO:0005730; GO:0005783; GO:0007080; GO:0030687; GO:0042273; GO:0044822 0 0 0 PF04939; Q9DCD5 CHOYP_LOC725079.1.1 m.66349 sp TJAP1_MOUSE 39.474 152 92 0 35 186 45 196 1.06E-24 107 TJAP1_MOUSE reviewed Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4) Tjap1 Pilt Tjp4 Mus musculus (Mouse) 539 Golgi organization [GO:0007030] GO:0005737; GO:0005768; GO:0005802; GO:0005886; GO:0005923; GO:0007030 0 0 0 PF15453; Q9ESJ1 CHOYP_LOC663548.1.2 m.35548 sp CABL1_MOUSE 46.415 265 127 2 206 469 318 568 1.06E-66 226 CABL1_MOUSE reviewed CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) Cables1 Cables Mus musculus (Mouse) 568 blood coagulation [GO:0007596]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; nervous system development [GO:0007399]; regulation of cell cycle [GO:0051726] GO:0000082; GO:0005654; GO:0005829; GO:0007399; GO:0007596; GO:0030426; GO:0051301; GO:0051726 0 0 0 PF00134; Q9ESN6 CHOYP_TRIM3.17.58 m.25566 sp TRIM2_MOUSE 28.431 102 71 1 56 155 631 732 1.06E-06 51.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.2.15 m.3501 sp SACS_MOUSE 26.998 1226 770 38 565 1698 942 2134 1.06E-103 374 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9R154 CHOYP_LOC100494580.1.1 m.35588 sp S26A4_RAT 28.736 87 60 1 15 99 655 741 1.06E-09 58.2 S26A4_RAT reviewed Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) Slc26a4 Pds Rattus norvegicus (Rat) 780 bicarbonate transport [GO:0015701]; inorganic anion transport [GO:0015698]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; regulation of pH [GO:0006885]; regulation of protein localization [GO:0032880] GO:0005254; GO:0005887; GO:0006885; GO:0008271; GO:0015106; GO:0015108; GO:0015111; GO:0015116; GO:0015301; GO:0015698; GO:0015701; GO:0016324; GO:0019531; GO:0031526; GO:0032880; GO:0042391; GO:0051453; GO:0070062 0 0 0 PF01740;PF00916; Q9UN19 CHOYP_LOC100631809.2.2 m.62573 sp DAPP1_HUMAN 46.809 235 121 3 3 234 27 260 1.06E-73 228 DAPP1_HUMAN reviewed Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) DAPP1 BAM32 HSPC066 Homo sapiens (Human) 280 protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165] GO:0005543; GO:0005547; GO:0005829; GO:0005886; GO:0006470; GO:0007165; GO:0043325 0 0 0 PF00169;PF00017; Q9UPN9 CHOYP_BRAFLDRAFT_88217.8.14 m.36456 sp TRI33_HUMAN 27.67 206 130 7 18 208 214 415 1.06E-06 55.5 TRI33_HUMAN reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) 1127 "negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0045892; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q9V8R9 CHOYP_E41L1.1.1 m.40411 sp 41_DROME 56.25 80 33 1 114 193 1621 1698 1.06E-19 89.7 41_DROME reviewed Protein 4.1 homolog (Protein coracle) cora CG11949 Drosophila melanogaster (Fruit fly) 1698 "adult somatic muscle development [GO:0007527]; cell adhesion involved in heart morphogenesis [GO:0061343]; cell-cell junction organization [GO:0045216]; chitin-based embryonic cuticle biosynthetic process [GO:0008362]; dorsal closure [GO:0007391]; embryo development [GO:0009790]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of cell polarity [GO:0007163]; heart process [GO:0003015]; maintenance of imaginal disc-derived wing hair orientation [GO:0035321]; protein targeting to membrane [GO:0006612]; regulation of tube size, open tracheal system [GO:0035151]; salivary gland morphogenesis [GO:0007435]; septate junction assembly [GO:0019991]" GO:0003015; GO:0005198; GO:0005856; GO:0005886; GO:0005918; GO:0005920; GO:0006612; GO:0007163; GO:0007391; GO:0007435; GO:0007527; GO:0008092; GO:0008362; GO:0009790; GO:0019991; GO:0035151; GO:0035321; GO:0045216; GO:0060857; GO:0061343 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379; Q9VCA8 CHOYP_LOC589530.1.1 m.46000 sp ANKHM_DROME 29.88 251 165 4 7 246 560 810 1.06E-21 98.6 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9Z1J2 CHOYP_NEMVEDRAFT_V1G79897.1.1 m.52661 sp NEK4_MOUSE 47.104 259 133 4 13 270 11 266 1.06E-70 244 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; A1L0T3 CHOYP_BRAFLDRAFT_230523.2.3 m.39175 sp SRB4D_MOUSE 37.283 346 165 9 18 358 174 472 1.07E-53 190 SRB4D_MOUSE reviewed Scavenger receptor cysteine-rich domain-containing group B protein (Four scavenger receptor cysteine-rich domains-containing protein) (S4D-SRCRB) Ssc4d Srcrb4d Mus musculus (Mouse) 586 0 GO:0005044; GO:0016020; GO:0070062 0 0 0 PF00530; A2RSX7 CHOYP_BRAFLDRAFT_118314.1.1 m.15657 sp TYW5_MOUSE 63.605 294 106 1 25 318 20 312 1.07E-139 400 TYW5_MOUSE reviewed tRNA wybutosine-synthesizing protein 5 (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) Tyw5 Mus musculus (Mouse) 315 wybutosine biosynthetic process [GO:0031591] GO:0000049; GO:0005506; GO:0016706; GO:0031591; GO:0042803 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 0 A2VDD2 CHOYP_BRAFLDRAFT_126379.1.3 m.5102 sp TC1DB_XENLA 31.148 122 82 1 157 278 57 176 1.07E-17 81.6 TC1DB_XENLA reviewed Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) 176 0 0 0 0 0 PF03645; A6QPH1 CHOYP_LOC100371258.1.1 m.55250 sp PYM1_BOVIN 50.833 120 49 3 14 129 8 121 1.07E-30 112 PYM1_BOVIN reviewed Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) PYM1 PYM WIBG Bos taurus (Bovine) 203 "exon-exon junction complex disassembly [GO:1903259]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]" GO:0000184; GO:0005654; GO:0005730; GO:0005737; GO:0035145; GO:0043022; GO:0044822; GO:0045727; GO:1903259 0 0 0 PF09282; A6QQZ0 CHOYP_GD1L1.1.1 m.11963 sp GDAP1_BOVIN 29.63 324 217 6 12 328 18 337 1.07E-36 138 GDAP1_BOVIN reviewed Ganglioside-induced differentiation-associated protein 1 (GDAP1) GDAP1 Bos taurus (Bovine) 358 glutathione metabolic process [GO:0006749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; protein targeting to mitochondrion [GO:0006626]; response to retinoic acid [GO:0032526] GO:0000266; GO:0004364; GO:0005634; GO:0005737; GO:0006626; GO:0006749; GO:0008053; GO:0031307; GO:0032526 0 0 0 PF13417; B2RXR6 CHOYP_LOC583072.9.25 m.38364 sp ANR44_MOUSE 24.103 1087 668 30 957 1994 11 989 1.07E-48 194 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; B3EWZ3 CHOYP_BRAFLDRAFT_88566.9.11 m.28924 sp CADN_ACRMI 43.318 434 233 5 34 458 142 571 1.07E-101 337 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; C3YWU0 CHOYP_LOC100184076.1.1 m.8035 sp FUCO_BRAFL 59.701 134 51 2 28 160 148 279 1.07E-49 168 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; D2GXS7 CHOYP_TRIM2.11.59 m.22405 sp TRIM2_AILME 30.328 122 79 3 223 340 620 739 1.07E-07 57 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZGS3 CHOYP_LOC100177344.1.1 m.65908 sp OCRL_RAT 36.224 196 108 4 28 219 216 398 1.07E-30 122 OCRL_RAT reviewed Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) Ocrl Rattus norvegicus (Rat) 902 cilium assembly [GO:0042384]; in utero embryonic development [GO:0001701]; phosphatidylinositol dephosphorylation [GO:0046856]; signal transduction [GO:0007165] GO:0001701; GO:0001750; GO:0004439; GO:0005096; GO:0005634; GO:0005769; GO:0005802; GO:0005886; GO:0005905; GO:0007165; GO:0030136; GO:0030670; GO:0031901; GO:0042384; GO:0046856; GO:0052745; GO:0070062 0 0 0 PF03372;PF16726;PF00620; D3ZVM4 CHOYP_BRAFLDRAFT_213530.3.3 m.51783 sp LIN41_RAT 21.176 595 364 20 18 584 186 703 1.07E-18 94 LIN41_RAT reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) Trim71 Lin41 Rattus norvegicus (Rat) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; I6V1W0 CHOYP_LOC100374938.1.1 m.56735 sp BMBL_DANRE 24.828 145 102 1 17 161 52 189 1.07E-07 58.2 BMBL_DANRE reviewed Protein brambleberry bmb Danio rerio (Zebrafish) (Brachydanio rerio) 612 karyomere membrane fusion [GO:0061472]; pronuclear fusion [GO:0007344] GO:0007344; GO:0016021; GO:0031965; GO:0061472 0 0 0 0 O14795 CHOYP_BRAFLDRAFT_102486.1.2 m.31218 sp UN13B_HUMAN 76.471 119 27 1 1 119 1339 1456 1.07E-55 189 UN13B_HUMAN reviewed Protein unc-13 homolog B (Munc13-2) (munc13) UNC13B UNC13 Homo sapiens (Human) 1591 "apoptotic process [GO:0006915]; chemical synaptic transmission [GO:0007268]; excretion [GO:0007588]; glutamate secretion [GO:0014047]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; neuromuscular junction development [GO:0007528]; neurotransmitter secretion [GO:0007269]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic vesicle priming [GO:0010808]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" GO:0004871; GO:0004872; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0006915; GO:0007165; GO:0007268; GO:0007269; GO:0007528; GO:0007588; GO:0010808; GO:0014047; GO:0016081; GO:0016082; GO:0019992; GO:0030054; GO:0031594; GO:0035249; GO:0035556; GO:0043195; GO:0046872; GO:0048172; GO:0048786; GO:0060384; GO:0097151 0 0 0 PF00130;PF00168;PF06292;PF10540; O43399 CHOYP_LOC100878467.2.4 m.11447 sp TPD54_HUMAN 33.951 162 74 3 131 272 55 203 1.07E-20 90.5 TPD54_HUMAN reviewed Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) 206 regulation of cell proliferation [GO:0042127] GO:0005737; GO:0042127; GO:0042803; GO:0044822; GO:0046982; GO:0048471 0 0 0 PF04201; O60462 CHOYP_NRP2.7.8 m.63073 sp NRP2_HUMAN 29.885 261 146 13 50 293 25 265 1.07E-18 93.6 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O70277 CHOYP_BRAFLDRAFT_255105.2.2 m.59564 sp TRIM3_RAT 28.455 123 83 3 240 358 622 743 1.07E-07 57.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75094 CHOYP_CAOG_02281.1.1 m.60208 sp SLIT3_HUMAN 21.97 132 99 1 55 186 90 217 1.07E-06 53.9 SLIT3_HUMAN reviewed Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) 1523 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; organ morphogenesis [GO:0009887]; regulation of axonogenesis [GO:0050770]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385] GO:0005509; GO:0005578; GO:0005615; GO:0005739; GO:0007411; GO:0008201; GO:0008285; GO:0009887; GO:0010629; GO:0030308; GO:0032870; GO:0035385; GO:0048495; GO:0048846; GO:0050770; GO:0050919; GO:0051414; GO:0061364; GO:0070100 0 0 0 PF00008;PF02210;PF13855;PF01463;PF01462; P04323 CHOYP_LOC100371186.2.3 m.6144 sp POL3_DROME 33.108 148 93 3 138 280 163 309 1.07E-18 89.4 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P09481 CHOYP_ACHB3.5.5 m.64487 sp ACHA3_CHICK 28.212 358 241 8 1 348 4 355 1.07E-48 176 ACHA3_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) 496 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; P0C7U4 CHOYP_DHR-1.1.1 m.43819 sp C3AR_DANRE 24.716 352 235 10 11 357 32 358 1.07E-19 92.4 C3AR_DANRE reviewed C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) c3ar1 Danio rerio (Zebrafish) (Brachydanio rerio) 361 chemotaxis [GO:0006935] GO:0004930; GO:0005886; GO:0006935; GO:0016021 0 0 0 PF00001; P11714 CHOYP_LOC579395.2.2 m.44926 sp CP2D9_MOUSE 27.49 502 338 11 19 511 14 498 1.07E-64 221 CP2D9_MOUSE reviewed Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (Cytochrome P450-16-alpha) (Cytochrome P450CA) (Testosterone 16-alpha hydroxylase) Cyp2d9 Cyp2d-9 Mus musculus (Mouse) 504 arachidonic acid metabolic process [GO:0019369] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019369; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P15364 CHOYP_LOC100864449.1.2 m.32004 sp AMAL_DROME 25.794 252 171 7 100 342 82 326 1.07E-07 57 AMAL_DROME reviewed Protein amalgam Ama CG2198 Drosophila melanogaster (Fruit fly) 333 0 GO:0005886; GO:0031225 0 0 0 PF07679; P16157 CHOYP_AAEL_AAEL014742.8.8 m.65999 sp ANK1_HUMAN 33.481 451 269 3 16 435 32 482 1.07E-69 243 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P19477 CHOYP_FIBB.3.3 m.57165 sp FIBA_PARPA 44.186 215 113 5 107 317 69 280 1.07E-49 169 FIBA_PARPA reviewed Fibrinogen-like protein A (FREP-A) 0 Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) 282 0 0 0 0 0 PF00147; P22105 CHOYP_DFA_00978.1.1 m.17875 sp TENX_HUMAN 26.437 261 146 16 76 315 222 457 1.07E-07 58.5 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P28075 CHOYP_NEMVEDRAFT_V1G173323.1.2 m.48758 sp PSB5_RAT 71.616 229 46 1 68 296 51 260 1.07E-114 334 PSB5_RAT reviewed Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit X) Psmb5 Rattus norvegicus (Rat) 263 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0051603 0 0 0 PF00227; P28824 CHOYP_NRP1.2.5 m.40310 sp NRP1_XENLA 30.279 251 149 11 53 292 27 262 1.07E-17 89.7 NRP1_XENLA reviewed Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) 928 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; endothelial cell chemotaxis [GO:0035767]; organ morphogenesis [GO:0009887]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005021; GO:0007411; GO:0008201; GO:0009887; GO:0016021; GO:0017154; GO:0035767; GO:0046872; GO:0048010 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P28827 CHOYP_LOC100208023.3.8 m.33951 sp PTPRM_HUMAN 29.5 600 390 14 576 1158 868 1451 1.07E-68 257 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P51798 CHOYP_CLCN6.1.1 m.3933 sp CLCN7_HUMAN 39.08 261 128 5 1 259 567 798 1.07E-47 172 CLCN7_HUMAN reviewed H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) CLCN7 Homo sapiens (Human) 805 ion transmembrane transport [GO:0034220]; response to pH [GO:0009268]; transport [GO:0006810] GO:0005247; GO:0005254; GO:0005524; GO:0005765; GO:0006810; GO:0009268; GO:0015297; GO:0016020; GO:0016021; GO:0031404; GO:0031410; GO:0034220 0 0 0 PF00571;PF00654; P51909 CHOYP_BRAFLDRAFT_125104.1.1 m.31139 sp APOD_CAVPO 41.765 170 95 3 23 190 18 185 1.07E-39 136 APOD_CAVPO reviewed Apolipoprotein D (Apo-D) (ApoD) APOD Cavia porcellus (Guinea pig) 189 aging [GO:0007568]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246] GO:0000302; GO:0005215; GO:0005615; GO:0005783; GO:0006006; GO:0006629; GO:0007420; GO:0007568; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0042493; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405 0 0 0 PF08212; P62752 CHOYP_RPL23A.1.3 m.48845 sp RL23A_RAT 70.732 82 24 0 49 130 31 112 1.07E-32 115 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P70031 CHOYP_CBR-NPR-1.1.1 m.45569 sp CCKAR_XENLA 22.581 341 239 10 29 355 80 409 1.07E-08 60.1 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; P97864 CHOYP_CASP10.4.7 m.45631 sp CASP7_MOUSE 24.224 322 170 12 2 316 45 299 1.07E-08 58.9 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 P98153 CHOYP_ISCW_ISCW017961.1.1 m.55650 sp IDD_HUMAN 36.275 204 94 7 22 210 271 453 1.07E-09 65.5 IDD_HUMAN reviewed Integral membrane protein DGCR2/IDD DGCR2 IDD KIAA0163 Homo sapiens (Human) 550 cell adhesion [GO:0007155]; cognition [GO:0050890]; organ morphogenesis [GO:0009887] GO:0007155; GO:0009887; GO:0016021; GO:0030246; GO:0050890 0 0 0 PF00057;PF00059; Q00560 CHOYP_LOC100576169.1.1 m.37772 sp IL6RB_MOUSE 22.894 463 309 20 229 672 219 652 1.07E-07 60.1 IL6RB_MOUSE reviewed Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) Il6st Mus musculus (Mouse) 917 ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; glycogen metabolic process [GO:0005977]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-6-mediated signaling pathway [GO:0070102]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell proliferation [GO:0008284]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tyrosine phosphorylation of Stat1 protein [GO:0042511]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; regulation of Notch signaling pathway [GO:0008593]; response to cytokine [GO:0034097]; signal transduction [GO:0007165] GO:0004897; GO:0004915; GO:0004923; GO:0004924; GO:0005127; GO:0005615; GO:0005896; GO:0005900; GO:0005977; GO:0007165; GO:0008284; GO:0008593; GO:0009897; GO:0016020; GO:0019221; GO:0019838; GO:0030425; GO:0034097; GO:0038154; GO:0038165; GO:0042102; GO:0042511; GO:0042517; GO:0043025; GO:0044297; GO:0045669; GO:0048711; GO:0048861; GO:0070062; GO:0070102; GO:0070104; GO:0070106; GO:0070110; GO:0070120 0 0 0 PF00041;PF09240;PF06328; Q00651 CHOYP_ITGA4.1.1 m.61418 sp ITA4_MOUSE 29.298 727 414 31 17 690 18 697 1.07E-58 223 ITA4_MOUSE reviewed Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d) Itga4 Mus musculus (Mouse) 1039 blood vessel remodeling [GO:0001974]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cell migration [GO:0016477]; chorio-allantoic fusion [GO:0060710]; face development [GO:0060324]; heart development [GO:0007507]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; mesenchyme development [GO:0060485]; negative regulation of protein homodimerization activity [GO:0090074]; receptor clustering [GO:0043113]; single organismal cell-cell adhesion [GO:0016337]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell migration [GO:0072678]; visceral serous pericardium development [GO:0061032] GO:0001968; GO:0001974; GO:0003366; GO:0005886; GO:0005911; GO:0005925; GO:0007155; GO:0007157; GO:0007159; GO:0007160; GO:0007229; GO:0007507; GO:0009897; GO:0009986; GO:0016020; GO:0016337; GO:0016477; GO:0034113; GO:0034446; GO:0034669; GO:0043113; GO:0046872; GO:0050839; GO:0050901; GO:0060324; GO:0060485; GO:0060710; GO:0061032; GO:0070062; GO:0072678; GO:0090074 0 0 0 PF01839;PF08441; Q09JW2 CHOYP_RL17.6.7 m.50378 sp RL17_ARGMO 75.806 186 44 1 49 234 1 185 1.07E-95 280 RL17_ARGMO reviewed 60S ribosomal protein L17 RpL17 Argas monolakensis (Mono lake bird tick) 185 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 cd00336; PF00237; Q0II70 CHOYP_LOC101068028.1.1 m.48694 sp F195A_BOVIN 34.839 155 84 5 1 141 1 152 1.07E-19 82.8 F195A_BOVIN reviewed Protein FAM195A FAM195A Bos taurus (Bovine) 155 0 0 0 0 0 PF14799; Q0JBH9 CHOYP_RCOM_1685980.1.1 m.24036 sp ERG3_ORYSJ 68.462 130 41 0 1 130 1 130 1.07E-59 184 ERG3_ORYSJ reviewed Elicitor-responsive protein 3 (OsERG3) (16 kDa phloem protein) (RPP16) ERG3 Os04g0531100 LOC_Os04g44870 OsJ_014914 OSJNBa0081C01.13 Oryza sativa subsp. japonica (Rice) 144 0 0 0 0 0 PF00168; Q0P5A1 CHOYP_LOC100366786.2.2 m.44740 sp DCTN3_BOVIN 40.69 145 86 0 13 157 35 179 1.07E-36 127 DCTN3_BOVIN reviewed Dynactin subunit 3 DCTN3 Bos taurus (Bovine) 186 cytokinesis [GO:0000910]; microtubule-based process [GO:0007017]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0000910; GO:0005813; GO:0005819; GO:0005869; GO:0007017; GO:0007067; GO:0030496; GO:0032154; GO:0048471 0 0 0 PF07426; Q0VGY8 CHOYP_LOC100640442.5.10 m.38769 sp TANC1_MOUSE 40.777 103 61 0 230 332 1113 1215 1.07E-15 82.8 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q14517 CHOYP_LOC100705241.1.1 m.5979 sp FAT1_HUMAN 30.786 458 279 17 10 451 2903 3338 1.07E-45 174 FAT1_HUMAN reviewed "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; single organismal cell-cell adhesion [GO:0016337] GO:0005509; GO:0005634; GO:0005886; GO:0005887; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016337; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q19417 CHOYP_LOC100879643.1.1 m.51230 sp YSNK_CAEEL 22.222 252 172 8 77 318 30 267 1.07E-07 57.8 YSNK_CAEEL reviewed Glycosyltransferase family 92 protein F13G3.3 (EC 2.4.1.-) F13G3.3 Caenorhabditis elegans 501 0 GO:0016021; GO:0016757 0 0 0 PF01697; Q1LZB4 CHOYP_LOC590756.3.6 m.40373 sp IFT46_BOVIN 68.675 83 20 1 1 83 201 277 1.07E-35 126 IFT46_BOVIN reviewed Intraflagellar transport protein 46 homolog IFT46 Bos taurus (Bovine) 301 cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; smoothened signaling pathway [GO:0007224] GO:0005737; GO:0005813; GO:0005929; GO:0007224; GO:0030992; GO:0031512; GO:0042073; GO:0042384 0 0 0 PF12317; Q28346 CHOYP_RL4.1.6 m.1147 sp RL4_CANLF 82.759 116 20 0 1 116 14 129 1.07E-65 209 RL4_CANLF reviewed 60S ribosomal protein L4 (60S ribosomal protein L1) RPL4 RPL1 Canis lupus familiaris (Dog) (Canis familiaris) 421 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF14374;PF00573; Q28J59 CHOYP_BRAFLDRAFT_239751.1.3 m.4768 sp F221A_XENTR 51.389 144 58 2 46 189 143 274 1.07E-41 146 F221A_XENTR reviewed Protein FAM221A fam221a TNeu087m24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 295 0 0 0 0 0 PF14753; Q2T9W1 CHOYP_LOC100371294.1.1 m.58633 sp SNX20_BOVIN 32.407 216 146 0 75 290 76 291 1.07E-34 131 SNX20_BOVIN reviewed Sorting nexin-20 SNX20 Bos taurus (Bovine) 316 protein transport [GO:0015031] GO:0005546; GO:0005634; GO:0005886; GO:0015031; GO:0031901; GO:0032266 0 0 0 PF00787; Q2YDJ4 CHOYP_HINT3.1.1 m.31570 sp HINT3_BOVIN 50 136 66 2 11 144 47 182 1.07E-47 155 HINT3_BOVIN reviewed Histidine triad nucleotide-binding protein 3 (HINT-3) (EC 3.-.-.-) (HINT-4) HINT3 HINT4 Bos taurus (Bovine) 182 0 GO:0000166; GO:0005634; GO:0005737; GO:0016787; GO:0070062 0 0 0 0 Q3SZQ6 CHOYP_NEMVEDRAFT_V1G240738.1.2 m.50376 sp RL32_BOVIN 67.717 127 41 0 18 144 9 135 1.07E-60 186 RL32_BOVIN reviewed 60S ribosomal protein L32 RPL32 Bos taurus (Bovine) 135 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 cd00513; PF01655; Q3UIR3 CHOYP_SI_DKEY-3H3.3.1.1 m.48877 sp DTX3L_MOUSE 54.592 196 87 2 194 388 553 747 1.07E-62 217 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q3UYG8 CHOYP_BRAFLDRAFT_123909.1.1 m.24337 sp MACD2_MOUSE 45.27 296 136 6 109 394 14 293 1.07E-71 241 MACD2_MOUSE reviewed O-acetyl-ADP-ribose deacetylase MACROD2 (EC 3.2.2.-) (EC 3.5.1.-) (MACRO domain-containing protein 2) ([Protein ADP-ribosylglutamate] hydrolase) Macrod2 Mus musculus (Mouse) 475 brain development [GO:0007420]; cellular response to DNA damage stimulus [GO:0006974]; protein de-ADP-ribosylation [GO:0051725]; purine nucleoside metabolic process [GO:0042278] GO:0005634; GO:0006974; GO:0007420; GO:0016798; GO:0019213; GO:0042278; GO:0051725 0 0 0 PF01661; Q58CU2 CHOYP_PHUM_PHUM310370.1.1 m.58175 sp E41L5_BOVIN 55.556 279 114 2 1 271 179 455 1.07E-96 306 E41L5_BOVIN reviewed Band 4.1-like protein 5 EPB41L5 Bos taurus (Bovine) 502 0 GO:0005737; GO:0005856; GO:0005912; GO:0019898 0 0 0 PF08736;PF09380;PF00373;PF09379; Q5JI69 CHOYP_CAOG_04006.1.1 m.5403 sp TDH_THEKO 36.857 350 214 4 8 355 5 349 1.07E-73 235 TDH_THEKO reviewed L-threonine 3-dehydrogenase (TDH) (EC 1.1.1.103) (L-threonine dehydrogenase) tdh TK0916 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) 350 L-threonine catabolic process to glycine [GO:0019518]; protein homotetramerization [GO:0051289]; threonine metabolic process [GO:0006566] GO:0005737; GO:0006566; GO:0008270; GO:0008743; GO:0016597; GO:0019518; GO:0051289; GO:0070403 "PATHWAY: Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00627, ECO:0000305|PubMed:19307254, ECO:0000305|PubMed:19616102}." 0 0 PF08240;PF00107; Q5R5M4 CHOYP_DANA_GF10083.1.1 m.66269 sp MOT9_PONAB 25.36 556 345 13 61 614 6 493 1.07E-49 184 MOT9_PONAB reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 509 0 GO:0005886; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q5T6F2 CHOYP_BRAFLDRAFT_125234.1.2 m.18716 sp UBAP2_HUMAN 41.36 353 140 23 419 731 792 1117 1.07E-37 155 UBAP2_HUMAN reviewed Ubiquitin-associated protein 2 (UBAP-2) UBAP2 KIAA1491 Homo sapiens (Human) 1119 0 GO:0005913; GO:0044822; GO:0098641 0 0 0 PF12478; Q5VUA4 CHOYP_PSMD2.3.3 m.59657 sp ZN318_HUMAN 32.449 490 263 18 647 1114 744 1187 1.07E-48 195 ZN318_HUMAN reviewed Zinc finger protein 318 (Endocrine regulatory protein) ZNF318 HRIHFB2436 Homo sapiens (Human) 2279 "meiotic cell cycle [GO:0051321]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0051321 0 0 0 0 Q60ZR7 CHOYP_AGAP_AGAP005057.1.1 m.62428 sp RIC3_CAEBR 28.926 121 59 5 22 137 49 147 1.07E-07 56.2 RIC3_CAEBR reviewed Resistance to inhibitors of cholinesterase protein 3 ric-3 CBG17683 Caenorhabditis briggsae 385 "protein localization to cell surface [GO:0034394]; synaptic transmission, cholinergic [GO:0007271]" GO:0005789; GO:0007271; GO:0016021; GO:0033130; GO:0034394; GO:0043005; GO:0043025; GO:0043231 0 0 0 PF15361; Q63425 CHOYP_LOC659306.1.1 m.11580 sp PRAX_RAT 38.636 88 53 1 156 242 15 102 1.07E-10 69.7 PRAX_RAT reviewed Periaxin Prx Rattus norvegicus (Rat) 1383 axon ensheathment [GO:0008366]; nerve development [GO:0021675] GO:0005634; GO:0005737; GO:0005886; GO:0008366; GO:0021675; GO:0030054; GO:0043209 0 0 0 0 Q6DIB5 CHOYP_MEG10.46.91 m.44759 sp MEG10_MOUSE 34.94 415 206 17 194 561 271 668 1.07E-45 181 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6GNG8 CHOYP_PKRI1.1.1 m.6615 sp PKRI1_XENLA 60 110 44 0 17 126 18 127 1.07E-40 138 PKRI1_XENLA reviewed PRKR-interacting protein 1 homolog prkrip1 Xenopus laevis (African clawed frog) 173 0 GO:0005730 0 0 0 PF06658; Q6MG64 CHOYP_BRAFLDRAFT_63397.3.8 m.14677 sp VWA7_RAT 30.435 391 218 13 76 456 98 444 1.07E-30 130 VWA7_RAT reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) 892 0 GO:0005576 0 0 0 0 Q6PDJ1 CHOYP_NEMVEDRAFT_V1G238894.2.11 m.37865 sp CAHD1_MOUSE 25.983 1043 673 35 34 1004 62 1077 1.07E-83 301 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6ZQ03 CHOYP_RS8.12.14 m.59492 sp FNBP4_MOUSE 45.217 115 56 1 632 739 522 636 1.07E-26 122 FNBP4_MOUSE reviewed Formin-binding protein 4 (Formin-binding protein 30) Fnbp4 Fbp30 Kiaa1014 Mus musculus (Mouse) 1031 0 GO:0005654 0 0 0 PF00397; Q6ZSB9 CHOYP_LOC100372183.1.1 m.31741 sp ZBT49_HUMAN 33.929 168 103 4 54 218 367 529 1.07E-22 106 ZBT49_HUMAN reviewed Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) 765 "cell cycle arrest [GO:0007050]; negative regulation of cell proliferation [GO:0008285]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0001223; GO:0005634; GO:0005737; GO:0006351; GO:0007050; GO:0008134; GO:0008285; GO:0043565; GO:0045944; GO:0046872 0 0 0 PF00651;PF00096;PF13912; Q7TN31 CHOYP_AGGF1.1.1 m.61840 sp AGGF1_MOUSE 44.444 306 156 7 689 983 404 706 1.07E-63 232 AGGF1_MOUSE reviewed Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (mVG5Q) Aggf1 Vg5q Mus musculus (Mouse) 711 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; mRNA processing [GO:0006397]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of RNA splicing [GO:0043484]; vasculogenesis [GO:0001570] GO:0001525; GO:0001570; GO:0001938; GO:0003723; GO:0005576; GO:0005737; GO:0006397; GO:0007155; GO:0016607; GO:0043484; GO:0045766; GO:0048471; GO:0071011 0 0 0 PF00498;PF01585; Q80YR4 CHOYP_LOC100119750.1.1 m.7019 sp ZN598_MOUSE 38.716 514 257 12 18 501 27 512 1.07E-107 359 ZN598_MOUSE reviewed Zinc finger protein 598 Znf598 Zfp598 Mus musculus (Mouse) 908 0 GO:0008270; GO:0044822 0 0 0 0 Q80ZA4 CHOYP_PKHD1L1.3.5 m.15980 sp PKHL1_MOUSE 43.485 637 345 8 2 632 3188 3815 1.07E-174 555 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8BIR2 CHOYP_LOC664103.1.1 m.20727 sp ASTE1_MOUSE 23.264 288 179 9 104 376 322 582 1.07E-14 79.7 ASTE1_MOUSE reviewed Protein asteroid homolog 1 Aste1 Mus musculus (Mouse) 672 0 0 0 0 0 0 Q8BXQ6 CHOYP_CZH9ORF3.1.1 m.13464 sp AMPO_MOUSE 33.286 709 361 14 21 625 117 817 1.07E-116 370 AMPO_MOUSE reviewed Aminopeptidase O (AP-O) (EC 3.4.11.-) Aopep Onpep Mus musculus (Mouse) 817 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004177; GO:0005730; GO:0005737; GO:0005886; GO:0006508; GO:0008237; GO:0008270; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF09127;PF01433; Q8BZI6 CHOYP_LOC100539677.1.1 m.1191 sp GUCD1_MOUSE 40.084 237 137 2 2 233 3 239 1.07E-55 181 GUCD1_MOUSE reviewed Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4) Gucd1 Mus musculus (Mouse) 239 0 0 0 0 0 PF09778; Q8CDF7 CHOYP_EGL.3.3 m.63182 sp EXD1_MOUSE 40.659 91 53 1 25 115 155 244 1.07E-08 60.8 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q8CIM5 CHOYP_GPR84.1.1 m.25335 sp GPR84_MOUSE 24.021 383 253 9 30 399 31 388 1.07E-12 72.4 GPR84_MOUSE reviewed G-protein coupled receptor 84 Gpr84 Mus musculus (Mouse) 396 neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200] GO:0005887; GO:0007200; GO:0007218; GO:0008528; GO:0043235 0 0 0 PF00001; Q8IYJ2 CHOYP_LOC100893805.1.1 m.47272 sp CJ067_HUMAN 28.571 245 159 4 42 281 72 305 1.07E-18 90.1 CJ067_HUMAN reviewed "Uncharacterized protein C10orf67, mitochondrial" C10orf67 LINC01552 Homo sapiens (Human) 551 0 GO:0005739 0 0 0 PF15821;PF15852; Q8LGG8 CHOYP_LOC100185549.4.6 m.57314 sp USPAL_ARATH 28.244 131 84 3 17 138 30 159 1.07E-13 67.8 USPAL_ARATH reviewed Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) 175 response to stress [GO:0006950] GO:0005886; GO:0006950; GO:0016208 0 0 0 PF00582; Q8N2E2 CHOYP_BRAFLDRAFT_80496.5.10 m.28006 sp VWDE_HUMAN 24.551 334 216 10 1594 1910 780 1094 1.07E-17 94 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NDA2 CHOYP_BRAFLDRAFT_74469.1.3 m.622 sp HMCN2_HUMAN 24.383 324 196 16 55 359 1769 2062 1.07E-06 55.8 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8NET8 CHOYP_TRPV3.1.3 m.36387 sp TRPV3_HUMAN 29.508 122 82 2 2 119 586 707 1.07E-09 61.6 TRPV3_HUMAN reviewed Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3) TRPV3 Homo sapiens (Human) 790 calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to heat [GO:0009408] GO:0005262; GO:0005886; GO:0005887; GO:0009408; GO:0042636; GO:0043235; GO:0070588; GO:0090280 0 0 0 PF12796;PF00520; Q8NFW1 CHOYP_BRAFLDRAFT_92090.2.7 m.19075 sp COMA1_HUMAN 32 250 155 7 28 267 32 276 1.07E-27 121 COMA1_HUMAN reviewed Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) 1626 0 GO:0005576; GO:0005578; GO:0005581; GO:0005788 0 0 0 PF01391;PF00092; Q8TBF8 CHOYP_BRAFLDRAFT_98567.2.2 m.62261 sp FA81A_HUMAN 28.406 345 224 7 80 413 31 363 1.07E-31 127 FA81A_HUMAN reviewed Protein FAM81A FAM81A Homo sapiens (Human) 368 0 0 0 0 0 0 Q91WV7 CHOYP_SLC31.2.5 m.15005 sp SLC31_MOUSE 34.606 393 225 9 2 386 10 378 1.07E-68 233 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q92622 CHOYP_LOC100377422.2.2 m.63083 sp RUBIC_HUMAN 35.521 960 499 20 1 890 44 953 1.07E-171 526 RUBIC_HUMAN reviewed Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron) RUBCN KIAA0226 Homo sapiens (Human) 972 autophagosome maturation [GO:0097352]; immune system process [GO:0002376]; multivesicular body sorting pathway [GO:0071985]; negative regulation of autophagosome maturation [GO:1901097]; negative regulation of autophagy [GO:0010507]; negative regulation of endocytosis [GO:0045806]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; phagocytosis [GO:0006909] GO:0002376; GO:0005654; GO:0005737; GO:0005764; GO:0005769; GO:0005770; GO:0006909; GO:0010507; GO:0043231; GO:0043553; GO:0045806; GO:0071985; GO:0097352; GO:1901097 0 0 0 PF02759;PF13901; Q92626 CHOYP_LOC100888739.1.1 m.36643 sp PXDN_HUMAN 26.05 238 151 10 268 498 397 616 1.07E-10 68.9 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q95ZJ1 CHOYP_DMOJ_GI18492.1.1 m.8903 sp GALT5_CAEEL 53.804 184 80 4 30 209 428 610 1.07E-63 211 GALT5_CAEEL reviewed Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans 626 protein O-linked glycosylation via threonine [GO:0018243] GO:0000139; GO:0004653; GO:0016021; GO:0018243; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q96EY1 CHOYP_DNJA3.1.1 m.15026 sp DNJA3_HUMAN 48.879 446 196 7 11 454 38 453 1.07E-146 431 DNJA3_HUMAN reviewed "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) 480 activation-induced cell death of T cells [GO:0006924]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell aging [GO:0007569]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of programmed cell death [GO:0043069]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to interferon-gamma [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] GO:0000122; GO:0005133; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006264; GO:0006457; GO:0006469; GO:0006919; GO:0006924; GO:0007005; GO:0007264; GO:0007528; GO:0007569; GO:0008134; GO:0008285; GO:0009408; GO:0019897; GO:0019901; GO:0030054; GO:0030695; GO:0031398; GO:0031594; GO:0032088; GO:0033077; GO:0034341; GO:0042102; GO:0042645; GO:0043065; GO:0043066; GO:0043069; GO:0043124; GO:0043154; GO:0043231; GO:0045211; GO:0046872; GO:0050821; GO:0051059; GO:0060336; GO:0071340 0 0 cd06257; PF00226;PF01556;PF00684; Q96I24 CHOYP_BRAFLDRAFT_124476.3.4 m.48503 sp FUBP3_HUMAN 46.439 351 139 6 26 346 163 494 1.07E-79 262 FUBP3_HUMAN reviewed Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) 572 "positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0001077; GO:0005634; GO:0005737; GO:0006351; GO:0010628; GO:0016020; GO:0044822; GO:0045893; GO:0045944 0 0 0 PF00013; Q96RW7 CHOYP_HMCN1.21.44 m.39752 sp HMCN1_HUMAN 24.897 1213 722 48 6 1163 851 1929 1.07E-67 255 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99020 CHOYP_HNRNPAB.1.1 m.54329 sp ROAA_MOUSE 65.432 81 28 0 22 102 70 150 1.07E-30 112 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q99315 CHOYP_LOC100141913.1.1 m.7985 sp YG31B_YEAST 31.958 945 546 24 288 1221 586 1444 1.07E-120 414 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9CQC8 CHOYP_BRAFLDRAFT_280343.1.1 m.41317 sp SPG21_MOUSE 66.786 280 93 0 6 285 4 283 1.07E-144 412 SPG21_MOUSE reviewed Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog) Spg21 Mus musculus (Mouse) 308 0 GO:0005737; GO:0005829; GO:0030140; GO:0042609; GO:0043231 0 0 0 PF00561; Q9CR14 CHOYP_LOC101172267.1.1 m.18436 sp FANCL_MOUSE 43.733 375 208 2 1 373 1 374 1.07E-119 354 FANCL_MOUSE reviewed E3 ubiquitin-protein ligase FANCL (EC 6.3.2.-) (Fanconi anemia group L protein homolog) (Proliferation of germ cells protein) Fancl Phf9 Pog Mus musculus (Mouse) 375 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; gamete generation [GO:0007276]; positive regulation of defense response to virus by host [GO:0002230]; protein monoubiquitination [GO:0006513]; regulation of cell proliferation [GO:0042127]; xenophagy [GO:0098792] GO:0002230; GO:0004842; GO:0005635; GO:0005737; GO:0006281; GO:0006513; GO:0006974; GO:0007276; GO:0016874; GO:0031625; GO:0042127; GO:0043240; GO:0046872; GO:0061630; GO:0098792 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF11793;PF09765; Q9CWL2 CHOYP_DNAH5.2.2 m.61453 sp CASZ1_MOUSE 68.212 151 48 0 2 152 544 694 1.07E-66 238 CASZ1_MOUSE reviewed Zinc finger protein castor homolog 1 (Castor-related protein) Casz1 Cst D4Ertd432e Kiaa3026 Mus musculus (Mouse) 1761 "central nervous system development [GO:0007417]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinal cone cell fate commitment [GO:0060226]; regulation of transcription, DNA-templated [GO:0006355]; retinal bipolar neuron differentiation [GO:0060040]; retinal rod cell fate commitment [GO:0060223]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0007417; GO:0043231; GO:0045665; GO:0046872; GO:0060040; GO:0060223; GO:0060226; GO:1902870 0 0 0 0 Q9CZJ2 CHOYP_HSPA12A.12.27 m.36398 sp HS12B_MOUSE 35.647 634 337 17 5 578 61 683 1.07E-116 364 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D581 CHOYP_LOC100375122.1.1 m.52296 sp EFC10_MOUSE 37.795 127 78 1 18 144 7 132 1.07E-26 100 EFC10_MOUSE reviewed EF-hand calcium-binding domain-containing protein 10 Efcab10 Mus musculus (Mouse) 132 0 GO:0005509 0 0 0 0 Q9D7Q1 CHOYP_CHIT.1.1 m.7 sp CHIT1_MOUSE 48.462 130 58 4 6 133 289 411 1.07E-29 124 CHIT1_MOUSE reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) Chit1 Mus musculus (Mouse) 464 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0006032; GO:0008061; GO:0008843 0 0 0 PF01607;PF00704; Q9D9R9 CHOYP_NEMVEDRAFT_V1G214844.7.34 m.21399 sp F186A_MOUSE 40.379 369 136 20 762 1061 588 941 1.07E-21 106 F186A_MOUSE reviewed Protein FAM186A FAM186A Gm920 Mus musculus (Mouse) 1790 0 0 0 0 0 0 Q9DB30 CHOYP_PHUM_PHUM607620.1.1 m.53372 sp PHKG2_MOUSE 54.391 353 160 1 133 484 24 376 1.07E-139 411 PHKG2_MOUSE reviewed "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-2)" Phkg2 Mus musculus (Mouse) 406 glycogen biosynthetic process [GO:0005978] GO:0004689; GO:0005524; GO:0005964; GO:0005978 0 0 0 PF00069; Q9ESN6 CHOYP_BRAFLDRAFT_86890.1.4 m.4714 sp TRIM2_MOUSE 22.967 209 140 6 223 421 534 731 1.07E-08 61.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAR2 CHOYP_GP116.1.1 m.59817 sp AGRL3_HUMAN 26.877 506 328 18 17 501 629 1113 1.07E-42 167 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9JLQ0 CHOYP_BRAFLDRAFT_90471.1.2 m.30257 sp CD2AP_MOUSE 43.252 326 154 7 1 296 1 325 1.07E-70 242 CD2AP_MOUSE reviewed CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1) Cd2ap Mets1 Mus musculus (Mouse) 637 cell division [GO:0051301]; cell migration [GO:0016477]; mitotic nuclear division [GO:0007067]; negative regulation of transforming growth factor beta1 production [GO:0032911]; positive regulation of protein localization to nucleus [GO:1900182]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of actin cytoskeleton reorganization [GO:2000249]; regulation of receptor-mediated endocytosis [GO:0048259]; single organismal cell-cell adhesion [GO:0016337]; vesicle organization [GO:0016050] GO:0001726; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005938; GO:0007067; GO:0016050; GO:0016337; GO:0016477; GO:0017124; GO:0030139; GO:0031941; GO:0032911; GO:0043161; GO:0048259; GO:0048471; GO:0051301; GO:0070062; GO:1900182; GO:2000249 0 0 0 PF00018;PF14604; Q9M7I7 CHOYP_BRAFLDRAFT_127482.1.1 m.5405 sp CLH2_ARATH 24.138 261 156 9 55 287 50 296 1.07E-08 58.9 CLH2_ARATH reviewed "Chlorophyllase-2, chloroplastic (AtCLH2) (EC 3.1.1.14) (Chlorophyll-chlorophyllido hydrolase 2) (Chlase 2)" CLH2 At5g43860 MQD19.22 Arabidopsis thaliana (Mouse-ear cress) 318 chlorophyll catabolic process [GO:0015996] GO:0009507; GO:0015996; GO:0031969; GO:0047746; GO:0102293 PATHWAY: Porphyrin-containing compound metabolism; chlorophyll degradation. 0 0 PF07224; Q9MYM7 CHOYP_LOC100706023.2.2 m.56684 sp B3GT1_PONPY 45.771 201 105 1 123 323 61 257 1.07E-53 181 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9NGC3 CHOYP_LOC100369235.1.1 m.41071 sp CEG1A_DROME 67.797 118 37 1 66 182 406 523 1.07E-39 147 CEG1A_DROME reviewed Centaurin-gamma-1A CenG1A CG31811 Drosophila melanogaster (Fruit fly) 995 medium-term memory [GO:0072375]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005096; GO:0005525; GO:0005622; GO:0007264; GO:0016020; GO:0043087; GO:0043547; GO:0046872; GO:0072375 0 0 0 PF01412;PF00071; Q9NPB8 CHOYP_GPCP1.1.1 m.11490 sp GPCP1_HUMAN 35.897 663 366 14 9 653 5 626 1.07E-129 401 GPCP1_HUMAN reviewed Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) GPCPD1 GDE5 KIAA1434 Homo sapiens (Human) 672 cellular phosphate ion homeostasis [GO:0030643]; glycerophospholipid catabolic process [GO:0046475]; skeletal muscle tissue development [GO:0007519] GO:0005829; GO:0007519; GO:0008889; GO:0030643; GO:0046475; GO:0047389; GO:2001070 0 0 0 PF00686;PF03009; Q9NRF2 CHOYP_LOC552012.1.1 m.65224 sp SH2B1_HUMAN 31.611 658 271 15 20 547 26 634 1.07E-75 259 SH2B1_HUMAN reviewed "SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)" SH2B1 KIAA1299 SH2B Homo sapiens (Human) 756 blood coagulation [GO:0007596]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of DNA biosynthetic process [GO:2000278] GO:0004871; GO:0005634; GO:0005829; GO:0007596; GO:0016020; GO:0030032; GO:0035556; GO:0035591; GO:0045840; GO:2000278 0 0 0 PF00169;PF08916;PF00017; Q9NZJ4 CHOYP_SACS.10.17 m.53238 sp SACS_HUMAN 24.647 2617 1602 93 51 2437 2097 4573 1.07E-155 546 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9R1R2 CHOYP_BRAFLDRAFT_85511.10.23 m.32711 sp TRIM3_MOUSE 24.783 230 139 9 337 549 480 692 1.07E-07 58.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UIC8 CHOYP_DPSE_GA17689.1.1 m.4920 sp LCMT1_HUMAN 45.484 310 135 3 2 278 21 329 1.07E-85 262 LCMT1_HUMAN reviewed Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1) LCMT1 LCMT CGI-68 Homo sapiens (Human) 334 cellular protein modification process [GO:0006464]; C-terminal protein methylation [GO:0006481]; negative regulation of protein complex assembly [GO:0031333]; protein methylation [GO:0006479]; regulation of apoptotic process [GO:0042981]; regulation of glucose metabolic process [GO:0010906]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] GO:0003880; GO:0005829; GO:0006464; GO:0006479; GO:0006481; GO:0008757; GO:0010906; GO:0018423; GO:0031333; GO:0042981; GO:0090266 0 0 0 PF04072; Q9UPW0 CHOYP_FOXJ2_3.1.1 m.1518 sp FOXJ3_HUMAN 45.847 301 98 6 20 268 18 305 1.07E-71 240 FOXJ3_HUMAN reviewed Forkhead box protein J3 FOXJ3 KIAA1041 Homo sapiens (Human) 622 "transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0005634; GO:0006351; GO:0043565 0 0 0 PF00250; Q9VZW5 CHOYP_CO6A5.1.6 m.5839 sp FMAR_DROME 29.243 383 208 17 17 365 87 440 1.07E-25 111 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; Q9W734 CHOYP_SMAD6.1.1 m.45333 sp SMAD6_CHICK 46.847 333 165 6 33 359 105 431 1.07E-90 281 SMAD6_CHICK reviewed Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (SMAD family member 6) (SMAD 6) (Smad6) SMAD6 MADH6 Gallus gallus (Chicken) 431 "aorta development [GO:0035904]; BMP signaling pathway [GO:0030509]; cell-substrate adhesion [GO:0031589]; coronary vasculature development [GO:0060976]; fat cell differentiation [GO:0045444]; heart valve development [GO:0003170]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of alkaline phosphatase activity [GO:0010693]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway involved in spinal cord association neuron specification [GO:1902879]; negative regulation of cell proliferation in dorsal spinal cord [GO:1902832]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of SMAD protein complex assembly [GO:0010991]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway [GO:1902844]; regulation of neurogenesis [GO:0050767]; response to laminar fluid shear stress [GO:0034616]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ureteric bud development [GO:0001657]; ventricular septum development [GO:0003281]; zygotic specification of dorsal/ventral axis [GO:0007352]" GO:0000978; GO:0001657; GO:0003170; GO:0003281; GO:0003682; GO:0003700; GO:0005634; GO:0005667; GO:0005768; GO:0006351; GO:0006955; GO:0007179; GO:0007352; GO:0010693; GO:0010991; GO:0030509; GO:0030512; GO:0030617; GO:0031589; GO:0032331; GO:0034616; GO:0035556; GO:0035904; GO:0043066; GO:0044212; GO:0045444; GO:0046872; GO:0050767; GO:0060394; GO:0060976; GO:1902832; GO:1902844; GO:1902879 0 0 0 PF03165;PF03166; Q9Y6I9 CHOYP_BRAFLDRAFT_203336.1.1 m.4677 sp TX264_HUMAN 39.608 255 123 6 73 301 23 272 1.07E-46 165 TX264_HUMAN reviewed Testis-expressed sequence 264 protein (Putative secreted protein Zsig11) TEX264 ZSIG11 UNQ337/PRO536 Homo sapiens (Human) 313 0 GO:0070062 0 0 0 0 A2AX52 CHOYP_LOC100486063.6.9 m.44251 sp CO6A4_MOUSE 22.846 1335 842 36 44 1354 34 1204 1.08E-76 285 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A8K8P3 CHOYP_LOC574744.1.1 m.26506 sp SFI1_HUMAN 25.117 1278 855 14 137 1393 41 1237 1.08E-106 371 SFI1_HUMAN reviewed Protein SFI1 homolog (hSFI1) SFI1 KIAA0542 Homo sapiens (Human) 1242 G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of phosphatase activity [GO:0010923] GO:0000086; GO:0005814; GO:0005829; GO:0010923; GO:0019902 0 0 0 0 A8WT26 CHOYP_CRE-DIG-1.1.1 m.26796 sp DHSD_CAEBR 41.441 111 55 2 76 180 39 145 1.08E-21 89 DHSD_CAEBR reviewed "Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (Succinate dehydrogenase complex subunit D)" sdhd-1 CBG02978 Caenorhabditis briggsae 145 tricarboxylic acid cycle [GO:0006099] GO:0005740; GO:0005743; GO:0005749; GO:0006099; GO:0016021; GO:0020037; GO:0046872; GO:0048039 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle. {ECO:0000305}. 0 cd03496; 0 B3EWY9 CHOYP_LOC100182237.2.2 m.33734 sp MLP_ACRMI 27.409 1069 621 38 821 1825 388 1365 1.08E-99 360 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; D2GXS7 CHOYP_LOC100376214.4.11 m.32730 sp TRIM2_AILME 29.323 133 86 4 71 200 617 744 1.08E-07 54.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O08762 CHOYP_BRAFLDRAFT_68917.3.3 m.30489 sp NETR_MOUSE 40.469 341 182 5 317 645 166 497 1.08E-71 253 NETR_MOUSE reviewed Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12) Prss12 Bssp3 Mus musculus (Mouse) 761 exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202 0 0 cd00190; PF00051;PF00530;PF00089; O14681 CHOYP_EI24.1.1 m.10171 sp EI24_HUMAN 47.256 328 165 3 1 327 1 321 1.08E-95 290 EI24_HUMAN reviewed Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein) EI24 PIG8 Homo sapiens (Human) 340 apoptotic process [GO:0006915]; autophagy [GO:0006914]; negative regulation of cell growth [GO:0030308] GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0006914; GO:0006915; GO:0016020; GO:0016021; GO:0030308; GO:0031965 0 0 0 0 O15990 CHOYP_KARG.8.11 m.45501 sp KARG_LIOJA 71.25 160 46 0 3 162 4 163 1.08E-79 243 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O61463 CHOYP_RLA2.5.9 m.16049 sp RLA2_CRYST 67.164 67 22 0 1 67 1 67 1.08E-25 95.9 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_87306.4.4 m.59605 sp TRIM3_RAT 27.5 120 82 3 62 177 625 743 1.08E-07 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_92727.13.17 m.48674 sp TRIM3_RAT 24.324 222 140 7 72 276 487 697 1.08E-06 53.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC100369333.12.32 m.32541 sp TRIM3_RAT 23.308 266 177 5 17 264 488 744 1.08E-15 80.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88609 CHOYP_LOC100497942.1.1 m.36378 sp LMX1B_MOUSE 38.953 344 174 5 5 312 52 395 1.08E-71 229 LMX1B_MOUSE reviewed LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B) Lmx1b Mus musculus (Mouse) 395 "camera-type eye development [GO:0043010]; cell proliferation [GO:0008283]; central nervous system neuron development [GO:0021954]; cerebellum morphogenesis [GO:0021587]; collagen fibril organization [GO:0030199]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; locomotory behavior [GO:0007626]; memory [GO:0007613]; midbrain development [GO:0030901]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; olfactory behavior [GO:0042048]; organ growth [GO:0035265]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of autophagy [GO:0010506]; regulation of gene expression [GO:0010468]; regulation of intracellular transport [GO:0032386]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; synapse organization [GO:0050808]; trabecular meshwork development [GO:0002930]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0001764; GO:0002930; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0006357; GO:0007613; GO:0007626; GO:0008270; GO:0008283; GO:0009953; GO:0010468; GO:0010506; GO:0021587; GO:0021954; GO:0030182; GO:0030199; GO:0030326; GO:0030901; GO:0032386; GO:0035108; GO:0035265; GO:0042048; GO:0043010; GO:0045944; GO:0050808; GO:0071542 0 0 0 PF00046;PF00412; P00687 CHOYP_LOC587610.1.3 m.16984 sp AMY1_MOUSE 49.511 511 220 15 1 479 1 505 1.08E-158 471 AMY1_MOUSE reviewed "Alpha-amylase 1 (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 1) (Salivary and hepatic alpha-amylase)" Amy1 Amy-1-a Amy1a Mus musculus (Mouse) 511 carbohydrate catabolic process [GO:0016052] GO:0004556; GO:0005509; GO:0005615; GO:0016052; GO:0016160; GO:0031404; GO:0070062 0 0 0 PF00128;PF02806; P02553 CHOYP_LOC100366892.2.3 m.51426 sp TBA_LYTPI 98.667 150 2 0 1 150 12 161 1.08E-108 308 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P0C1H5 CHOYP_DVIR_GJ23521.1.1 m.2757 sp H2B7_CHICK 87.069 116 13 1 12 127 13 126 1.08E-68 205 H2B7_CHICK reviewed Histone H2B 7 (H2B VII) H2B-VII Gallus gallus (Chicken) 126 nucleosome assembly [GO:0006334] GO:0000788; GO:0003677; GO:0005811; GO:0006334 0 0 0 PF00125; P15989 CHOYP_LOC101173335.2.4 m.33982 sp CO6A3_CHICK 23.355 1884 1260 64 1 1826 53 1810 1.08E-117 424 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P16157 CHOYP_TVAG_168010.33.45 m.57924 sp ANK1_HUMAN 32.852 554 366 3 159 711 40 588 1.08E-85 299 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20483 CHOYP_LOC100711118.1.1 m.14922 sp MPIP_DROME 49.388 245 110 3 378 608 217 461 1.08E-75 252 MPIP_DROME reviewed M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string) stg cdc25 CG1395 Drosophila melanogaster (Fruit fly) 479 "cell division [GO:0051301]; cell proliferation [GO:0008283]; centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of cell size [GO:0045792]; negative regulation of mitotic cell cycle [GO:0045930]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; protein dephosphorylation [GO:0006470]; regulation of cell diameter [GO:0060305]; regulation of mitotic cell cycle [GO:0007346]" GO:0000086; GO:0000278; GO:0004725; GO:0005634; GO:0005694; GO:0006470; GO:0007030; GO:0007067; GO:0007099; GO:0007346; GO:0007369; GO:0007422; GO:0007424; GO:0007488; GO:0007498; GO:0008138; GO:0008283; GO:0008284; GO:0045792; GO:0045930; GO:0045931; GO:0045977; GO:0046331; GO:0051301; GO:0060305 0 0 0 PF00581; P21941 CHOYP_VWA2.3.3 m.58785 sp MATN1_HUMAN 32.663 199 121 5 30 223 268 458 1.08E-21 100 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P34457 CHOYP_LOC100493525.1.2 m.17713 sp YMD3_CAEEL 34.272 213 105 5 92 302 8 187 1.08E-26 110 YMD3_CAEEL reviewed Putative uncharacterized transposon-derived protein F54H12.3 F54H12.3 Caenorhabditis elegans 286 DNA integration [GO:0015074] GO:0003676; GO:0015074 0 0 0 PF00665; P34465 CHOYP_LOC100693612.1.1 m.52278 sp CY561_CAEEL 41.152 243 135 4 7 243 13 253 1.08E-57 187 CY561_CAEEL reviewed Putative cytochrome b561 (Cytochrome b-561) F55H2.5 Caenorhabditis elegans 266 oxidation-reduction process [GO:0055114] GO:0005765; GO:0016021; GO:0016491; GO:0031902; GO:0046872; GO:0055114 0 0 0 PF03188; P35408 CHOYP_LOC100705061.2.2 m.25535 sp PE2R4_HUMAN 31.232 349 195 7 78 384 25 370 1.08E-38 148 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P40199 CHOYP_CEACAM5.4.5 m.50031 sp CEAM6_HUMAN 29.496 139 80 5 83 219 197 319 1.08E-08 59.7 CEAM6_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c) CEACAM6 NCA Homo sapiens (Human) 344 cell-cell signaling [GO:0007267]; leukocyte migration [GO:0050900]; signal transduction [GO:0007165] GO:0005615; GO:0005886; GO:0005887; GO:0007165; GO:0007267; GO:0031225; GO:0050900 0 0 0 PF13895;PF07686; P42577 CHOYP_FRIS.2.11 m.21374 sp FRIS_LYMST 84.559 136 21 0 1 136 1 136 1.08E-83 246 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P49869 CHOYP_LOC100373323.1.1 m.36010 sp HR38_DROME 65.306 343 112 3 293 635 738 1073 1.08E-138 434 HR38_DROME reviewed Probable nuclear hormone receptor HR38 (dHR38) (Nuclear receptor subfamily 4 group A member 4) Hr38 NR4A4 CG1864 Drosophila melanogaster (Fruit fly) 1073 "cuticle development [GO:0042335]; phagocytosis [GO:0006909]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of adult chitin-containing cuticle pigmentation [GO:0048082]; regulation of glucose metabolic process [GO:0010906]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003707; GO:0004879; GO:0005634; GO:0006351; GO:0006909; GO:0008270; GO:0010906; GO:0042335; GO:0045944; GO:0048082 0 0 0 PF00104;PF00105; P52183 CHOYP_TGM1.1.2 m.5148 sp ANNU_SCHAM 36.326 724 417 16 87 796 67 760 1.08E-152 468 ANNU_SCHAM reviewed Annulin (Protein-glutamine gamma-glutamyltransferase) (EC 2.3.2.13) (Transglutaminase) 0 Schistocerca americana (American grasshopper) 772 peptide cross-linking [GO:0018149] GO:0003810; GO:0005886; GO:0018149; GO:0046872 0 0 0 PF00927;PF01841;PF00868; P53817 CHOYP_BRAFLDRAFT_119296.5.16 m.16199 sp HRSL3_RAT 33.775 151 93 2 22 171 3 147 1.08E-18 81.6 HRSL3_RAT reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein) Pla2g16 H-rev107 Hrasls3 Hrev107 Rattus norvegicus (Rat) 160 lipid catabolic process [GO:0016042]; negative regulation of cell cycle [GO:0045786]; phospholipid biosynthetic process [GO:0008654] GO:0004623; GO:0005737; GO:0005783; GO:0008654; GO:0008970; GO:0016020; GO:0016021; GO:0016042; GO:0045786; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; P55042 CHOYP_LOC100876031.1.1 m.49110 sp RAD_HUMAN 35.437 206 114 6 171 363 92 291 1.08E-26 110 RAD_HUMAN reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) RRAD RAD Homo sapiens (Human) 308 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; P58365 CHOYP_DPSE_GA19599.1.1 m.64309 sp CAD23_RAT 27.484 1761 1093 68 87 1799 1475 3099 1.08E-113 406 CAD23_RAT reviewed Cadherin-23 (Otocadherin) Cdh23 Rattus norvegicus (Rat) 3317 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0005509; GO:0005886; GO:0007156; GO:0007605; GO:0007626; GO:0016021; GO:0032420; GO:0045177; GO:0047485; GO:0060122 0 0 0 PF00028; P61255 CHOYP_LOC100370236.3.3 m.40684 sp RL26_MOUSE 80.714 140 26 1 30 168 1 140 1.08E-79 237 RL26_MOUSE reviewed 60S ribosomal protein L26 (Silica-induced gene 20 protein) (SIG-20) Rpl26 Mus musculus (Mouse) 145 cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0002181; GO:0003735; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0044822; GO:0070062 0 0 0 PF00467;PF16906; P70031 CHOYP_LOC100893171.1.1 m.31395 sp CCKAR_XENLA 21.995 391 256 14 15 394 51 403 1.08E-08 60.5 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; P70345 CHOYP_LOC100374347.2.2 m.25868 sp B2CL2_MOUSE 38.547 179 104 4 5 179 9 185 1.08E-37 131 B2CL2_MOUSE reviewed Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) (c98) Bcl2l2 Bclw Kiaa0271 Mus musculus (Mouse) 193 extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; Sertoli cell proliferation [GO:0060011] GO:0005741; GO:0005829; GO:0008630; GO:0031966; GO:0042803; GO:0043066; GO:0046982; GO:0060011; GO:0070062; GO:0097192; GO:2001243 0 0 0 PF00452;PF02180; P70501 CHOYP_LOC100119417.1.1 m.44806 sp RBM10_RAT 49.18 61 25 2 61 121 115 169 1.08E-10 61.2 RBM10_RAT reviewed RNA-binding protein 10 (RNA-binding motif protein 10) (RNA-binding protein S1-1) Rbm10 Rattus norvegicus (Rat) 852 "regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003723; GO:0005634; GO:0008270; GO:0008380; GO:0042981 0 0 0 PF01585;PF00076;PF00641; P70541 CHOYP_LOC100375678.1.1 m.51537 sp EI2BG_RAT 41.111 450 255 5 1 446 1 444 1.08E-119 360 EI2BG_RAT reviewed Translation initiation factor eIF-2B subunit gamma (eIF-2B GDP-GTP exchange factor subunit gamma) Eif2b3 Eif2bg Rattus norvegicus (Rat) 452 cellular response to stimulus [GO:0051716]; hippocampus development [GO:0021766]; oligodendrocyte development [GO:0014003]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413] GO:0003743; GO:0005085; GO:0005737; GO:0005851; GO:0006412; GO:0006413; GO:0009408; GO:0009749; GO:0014003; GO:0016779; GO:0021766; GO:0043434; GO:0051716 0 0 0 PF00483; P79745 CHOYP_HDG10.1.1 m.14792 sp P3F3B_DANRE 39.394 66 40 0 12 77 345 410 1.08E-06 51.2 P3F3B_DANRE reviewed "POU domain, class 3, transcription factor 3-B (Brain-specific homeobox/POU domain protein 1.0) (Brain-1.0) (zfBrn-1.0) (POU domain protein 1) (ZFPOU1) (POU domain protein 23) (ZP-23)" pou3f3b brn-1.0 pou1 pou23 zp23 zp23pou Danio rerio (Zebrafish) (Brachydanio rerio) 443 "brain development [GO:0007420]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0007420; GO:0043565 0 0 0 PF00046;PF00157; P86854 CHOYP_LOC100710612.1.1 m.5450 sp PLCL_MYTGA 27.612 134 92 4 3 134 26 156 1.08E-16 75.1 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P86854 CHOYP_PGCA.1.3 m.5905 sp PLCL_MYTGA 34 150 88 4 20 168 17 156 1.08E-25 99.4 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P98203 CHOYP_LOC100377263.1.1 m.44874 sp ARVC_MOUSE 39.432 563 286 16 479 1018 343 873 1.08E-105 358 ARVC_MOUSE reviewed Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog Arvcf Mus musculus (Mouse) 962 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; multicellular organism development [GO:0007275]; single organismal cell-cell adhesion [GO:0016337] GO:0005634; GO:0005737; GO:0005886; GO:0007275; GO:0016337; GO:0016339 0 0 0 PF00514; Q02343 CHOYP_SMP_020170.1.1 m.23702 sp CAC1E_RABIT 37.553 237 146 2 2 238 18 252 1.08E-47 174 CAC1E_RABIT reviewed "Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)" CACNA1E CACH6 CACNL1A6 Oryctolagus cuniculus (Rabbit) 2259 0 GO:0005245; GO:0005509; GO:0005891 0 0 0 PF08763;PF16905;PF00520; Q02543 CHOYP_LOC100215958.1.1 m.22653 sp RL18A_HUMAN 66.667 174 58 0 1 174 1 174 1.08E-85 252 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q03650 CHOYP_contig_036780 m.41388 sp CRAM_TRYBB 27.496 571 396 8 80 649 194 747 1.08E-24 114 CRAM_TRYBB reviewed "Cysteine-rich, acidic integral membrane protein" CRAM Trypanosoma brucei brucei 945 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021; GO:0020016 0 0 0 PF07016; Q05B89 CHOYP_NIF3L.2.2 m.61215 sp NIF3L_BOVIN 43.614 321 166 4 1 309 28 345 1.08E-86 267 NIF3L_BOVIN reviewed NIF3-like protein 1 NIF3L1 Bos taurus (Bovine) 377 "negative regulation of nucleic acid-templated transcription [GO:1903507]; neuron differentiation [GO:0030182]; positive regulation of transcription, DNA-templated [GO:0045893]" GO:0005634; GO:0005737; GO:0005739; GO:0030182; GO:0045893; GO:1903507 0 0 0 PF01784; Q08CS6 CHOYP_ISCW_ISCW015652.1.1 m.58248 sp MOXD2_DANRE 27.273 132 89 3 4 135 56 180 1.08E-07 52.8 MOXD2_DANRE reviewed DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-) moxd2 moxd1l si:ch211-203k16.5 Danio rerio (Zebrafish) (Brachydanio rerio) 572 0 GO:0005507; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q0VAA2 CHOYP_LOC100372392.3.8 m.26479 sp LR74A_HUMAN 36.259 433 248 9 138 556 65 483 1.08E-72 244 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q14162 CHOYP_MEG10.31.91 m.34457 sp SREC_HUMAN 42.667 75 41 2 20 92 252 326 1.08E-10 63.5 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q28J82 CHOYP_WN11B.1.1 m.10960 sp W11B2_XENTR 48.406 345 174 4 13 354 10 353 1.08E-116 345 W11B2_XENTR reviewed Protein Wnt-11b-2 wnt11b-2 wnt11 wnt11b TNeu076g04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 cell fate commitment [GO:0045165]; gastrulation [GO:0007369]; neuron differentiation [GO:0030182]; Wnt signaling pathway [GO:0016055] GO:0005109; GO:0005576; GO:0005578; GO:0005615; GO:0007369; GO:0016055; GO:0030182; GO:0045165 0 0 0 PF00110; Q2TBP2 CHOYP_HINFP.1.1 m.16265 sp HINFP_BOVIN 50.122 411 182 6 2 399 3 403 1.08E-142 426 HINFP_BOVIN reviewed Histone H4 transcription factor (Histone nuclear factor P) (HiNF-P) (MBD2-interacting zinc finger protein) (Methyl-CpG-binding protein 2-interacting zinc finger protein) HINFP MIZF Bos taurus (Bovine) 516 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q3MHG0 CHOYP_LOC580207.1.1 m.49071 sp COG4_BOVIN 50.148 337 166 1 18 354 33 367 1.08E-118 363 COG4_BOVIN reviewed Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) COG4 Bos taurus (Bovine) 785 "Golgi organization [GO:0007030]; Golgi vesicle prefusion complex stabilization [GO:0048213]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0000301; GO:0006890; GO:0007030; GO:0015031; GO:0017119; GO:0048213 0 0 0 PF08318; Q3SYW0 CHOYP_LOC591037.1.1 m.51192 sp FBX15_BOVIN 26.829 451 297 11 62 492 29 466 1.08E-43 163 FBX15_BOVIN reviewed F-box only protein 15 FBXO15 Bos taurus (Bovine) 466 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0000151; GO:0043161 0 0 0 PF12937; Q3TI53 CHOYP_SCHIP1.1.1 m.19358 sp SCHI1_MOUSE 39.245 265 122 8 352 583 217 475 1.08E-37 149 SCHI1_MOUSE reviewed Schwannomin-interacting protein 1 (SCHIP-1) Schip1 Mus musculus (Mouse) 484 estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; luteinization [GO:0001553]; nitrogen compound metabolic process [GO:0006807]; palate development [GO:0060021]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745] GO:0001553; GO:0001822; GO:0005737; GO:0006807; GO:0008210; GO:0008585; GO:0009791; GO:0010761; GO:0042802; GO:0042803; GO:0048008; GO:0048705; GO:0048745; GO:0060021; GO:0060325 0 0 0 PF10148; Q40375 CHOYP_contig_003856 m.4391 sp PRP2_MEDTR 29.57 372 234 7 1 371 26 370 1.08E-32 129 PRP2_MEDTR reviewed Repetitive proline-rich cell wall protein 2 PRP2 Medicago truncatula (Barrel medic) (Medicago tribuloides) 371 multicellular organism development [GO:0007275] GO:0005199; GO:0005576; GO:0005618; GO:0007275 0 0 0 PF02095; Q4LDE5 CHOYP_LOC100367084.18.22 m.55778 sp SVEP1_HUMAN 25.145 688 417 24 129 734 435 1106 1.08E-39 166 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4V7T8 CHOYP_LOC589108.1.2 m.9688 sp ROP1L_XENLA 57.143 217 93 0 5 221 3 219 1.08E-89 266 ROP1L_XENLA reviewed Ropporin-1-like protein ropn1l Xenopus laevis (African clawed frog) 219 0 0 0 0 0 PF02197; Q4V7T8 CHOYP_LOC589108.2.2 m.48074 sp ROP1L_XENLA 57.143 217 93 0 5 221 3 219 1.08E-89 266 ROP1L_XENLA reviewed Ropporin-1-like protein ropn1l Xenopus laevis (African clawed frog) 219 0 0 0 0 0 PF02197; Q502M6 CHOYP_LOC755521.24.28 m.56885 sp ANR29_DANRE 33.149 181 100 3 4 166 43 220 1.08E-23 98.6 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q52KK4 CHOYP_NAF1.1.1 m.13716 sp NAF1_RAT 36.431 269 146 6 214 479 136 382 1.08E-44 168 NAF1_RAT reviewed H/ACA ribonucleoprotein complex non-core subunit NAF1 Naf1 Rattus norvegicus (Rat) 457 pseudouridine synthesis [GO:0001522]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364] GO:0001522; GO:0003723; GO:0005634; GO:0005732; GO:0005737; GO:0006364; GO:0042254 0 0 0 PF04410; Q5ND28 CHOYP_LOC100890774.1.1 m.42915 sp SREC_MOUSE 37.727 220 123 11 181 400 212 417 1.08E-27 119 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5PPV3 CHOYP_BRAFLDRAFT_280249.1.1 m.26508 sp MORN3_XENLA 62.185 238 89 1 1 237 1 238 1.08E-107 313 MORN3_XENLA reviewed MORN repeat-containing protein 3 morn3 Xenopus laevis (African clawed frog) 238 0 0 0 0 0 PF02493; Q5RC94 CHOYP_LOC100372432.2.3 m.12391 sp NBR1_PONAB 30.044 456 234 16 209 660 154 528 1.08E-43 173 NBR1_PONAB reviewed Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) NBR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 894 macroautophagy [GO:0016236]; protein oligomerization [GO:0051259] GO:0005764; GO:0005770; GO:0005776; GO:0005829; GO:0008270; GO:0016236; GO:0031410; GO:0031430; GO:0043130; GO:0051259 0 0 cd14947; PF16158;PF00564;PF00569; Q66HS7 CHOYP_ISCW_ISCW000210.1.4 m.2037 sp PDLI3_RAT 50.704 71 34 1 13 82 12 82 1.08E-12 68.6 PDLI3_RAT reviewed PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) (SK-2) Pdlim3 Rattus norvegicus (Rat) 362 0 GO:0008270; GO:0030018; GO:0042805 0 0 0 PF15936;PF00412;PF00595; Q69ZM6 CHOYP_LOC100372921.1.2 m.34923 sp STK36_MOUSE 38.132 910 501 16 1 889 88 956 1.08E-177 551 STK36_MOUSE reviewed Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) Stk36 Kiaa1278 Mus musculus (Mouse) 1316 brain development [GO:0007420]; cilium assembly [GO:0042384]; epithelial cilium movement [GO:0003351]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090] GO:0003351; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0007228; GO:0007420; GO:0008134; GO:0009791; GO:0042384; GO:0045880; GO:0046872; GO:0051090 0 0 0 PF00069; Q6DBR0 CHOYP_RUSD4.1.1 m.34216 sp RUSD4_DANRE 24.691 324 173 15 70 370 75 350 1.08E-08 60.1 RUSD4_DANRE reviewed RNA pseudouridylate synthase domain-containing protein 4 rpusd4 zgc:92006 Danio rerio (Zebrafish) (Brachydanio rerio) 358 tRNA pseudouridine synthesis [GO:0031119] GO:0003723; GO:0005739; GO:0009982; GO:0031119 0 0 0 PF00849; Q6DBY9 CHOYP_CHST1.1.3 m.20120 sp CHST1_DANRE 22.552 337 214 11 70 369 72 398 1.08E-08 60.1 CHST1_DANRE reviewed Carbohydrate sulfotransferase 1 (EC 2.8.2.21) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) chst1 zgc:100904 Danio rerio (Zebrafish) (Brachydanio rerio) 420 carbohydrate metabolic process [GO:0005975]; sulfur compound metabolic process [GO:0006790] GO:0000139; GO:0001517; GO:0005975; GO:0006790; GO:0016021; GO:0045130 0 0 0 PF00685; Q6DIB5 CHOYP_TTL11.1.1 m.51011 sp MEG10_MOUSE 37.157 619 342 28 106 713 268 850 1.08E-82 288 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6DRI7 CHOYP_LOC100377194.2.2 m.16184 sp DDX51_DANRE 42.012 676 303 11 1 661 1 602 1.08E-154 464 DDX51_DANRE reviewed ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51) ddx51 Danio rerio (Zebrafish) (Brachydanio rerio) 652 RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364] GO:0003723; GO:0004004; GO:0005524; GO:0005730; GO:0006364; GO:0010501 0 0 0 PF00270;PF00271; Q6GMG8 CHOYP_BRAFLDRAFT_125998.1.1 m.63212 sp LITAF_DANRE 39.216 102 60 2 32 132 62 162 1.08E-15 72 LITAF_DANRE reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf zgc:91882 Danio rerio (Zebrafish) (Brachydanio rerio) 163 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006355 0 0 0 PF10601; Q6GNV7 CHOYP_BRAFLDRAFT_123149.1.1 m.58961 sp DIRC2_XENLA 35.417 192 113 4 11 192 13 203 1.08E-27 111 DIRC2_XENLA reviewed Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) 456 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6ZRF8 CHOYP_BRAFLDRAFT_128153.2.5 m.23109 sp RN207_HUMAN 32.692 104 63 5 17 118 103 201 1.08E-08 55.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7TNC8 CHOYP_GLRA2.2.2 m.7241 sp GLRA2_MOUSE 42.08 423 188 9 15 387 26 441 1.08E-108 330 GLRA2_MOUSE reviewed Glycine receptor subunit alpha-2 Glra2 Mus musculus (Mouse) 452 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; response to amino acid [GO:0043200]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0007218; GO:0007416; GO:0016594; GO:0016934; GO:0021510; GO:0022852; GO:0030054; GO:0034220; GO:0034707; GO:0042995; GO:0043200; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; Q86TZ1 CHOYP_LOC587791.3.3 m.48123 sp TTC6_HUMAN 46.465 396 212 0 1756 2151 121 516 1.08E-114 378 TTC6_HUMAN reviewed Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 Homo sapiens (Human) 520 0 0 0 0 0 PF00515;PF13181; Q8CFH6 CHOYP_LOC100638884.1.1 m.49835 sp SIK2_MOUSE 42.292 253 144 2 38 289 20 271 1.08E-58 213 SIK2_MOUSE reviewed Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) Sik2 Snf1lk2 Mus musculus (Mouse) 931 insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of insulin receptor signaling pathway [GO:0046626] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008286; GO:0035556; GO:0046626; GO:0046777 0 0 0 PF00069; Q8IUF1 CHOYP_CBWD1.1.1 m.6825 sp CBWD2_HUMAN 55.927 329 141 2 18 345 41 366 1.08E-135 395 CBWD2_HUMAN reviewed COBW domain-containing protein 2 (Cobalamin synthase W domain-containing protein 2) CBWD2 Homo sapiens (Human) 395 0 GO:0005524 0 0 0 PF02492;PF07683; Q8J0F5 CHOYP_LOC100373061.2.2 m.66225 sp MLCB_PENCI 30.585 376 224 13 104 452 2196 2561 1.08E-32 138 MLCB_PENCI reviewed Compactin diketide synthase mokB (EC 2.3.1.-) (Compactin biosynthesis protein B) mlcB Penicillium citrinum 2563 0 GO:0008168; GO:0016491; GO:0016746; GO:0031177 PATHWAY: Polyketide biosynthesis. {ECO:0000305}. 0 0 PF00698;PF00107;PF16197;PF00109;PF02801;PF08659;PF08242;PF00550;PF14765; Q8K0U4 CHOYP_BRAFLDRAFT_208293.2.20 m.21358 sp HS12A_MOUSE 32.615 325 161 11 13 287 56 372 1.08E-39 149 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N539 CHOYP_BRAFLDRAFT_252169.3.6 m.23119 sp FBCD1_HUMAN 42.601 223 111 5 177 392 243 455 1.08E-45 166 FBCD1_HUMAN reviewed Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) 461 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q8NDX2 CHOYP_SLC17A8.1.1 m.52080 sp VGLU3_HUMAN 38.406 276 162 4 1 271 239 511 1.08E-62 211 VGLU3_HUMAN reviewed Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) SLC17A8 VGLUT3 Homo sapiens (Human) 589 brain development [GO:0007420]; cochlea development [GO:0090102]; ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter transport [GO:0006836]; sensory perception of sound [GO:0007605]; sodium ion transport [GO:0006814] GO:0003407; GO:0005313; GO:0005771; GO:0006811; GO:0006814; GO:0006836; GO:0007420; GO:0007605; GO:0015293; GO:0016021; GO:0030054; GO:0030672; GO:0043204; GO:0043679; GO:0060076; GO:0090102; GO:0097440; GO:0097441; GO:0097451; GO:1990030 0 0 cd06174; PF07690; Q8R1P4 CHOYP_LOC100374111.1.1 m.22087 sp ATG10_MOUSE 40.566 212 105 6 8 202 2 209 1.08E-39 138 ATG10_MOUSE reviewed Ubiquitin-like-conjugating enzyme ATG10 (EC 6.3.2.-) (Autophagy-related protein 10) (APG10-like) (mAPG10) Atg10 Apg10l Mus musculus (Mouse) 215 autophagy [GO:0006914]; autophagy in response to ER overload [GO:0034263]; macroautophagy [GO:0016236]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031] GO:0005622; GO:0005829; GO:0006497; GO:0006914; GO:0015031; GO:0016236; GO:0016874; GO:0019777; GO:0031401; GO:0032446; GO:0034263 0 0 0 PF03987; Q95WA0 CHOYP_ISCW_ISCW017655.1.1 m.22914 sp RL26_LITLI 81.56 141 24 1 9 147 1 141 1.08E-80 237 RL26_LITLI reviewed 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) 144 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 0 PF00467;PF16906; Q969T9 CHOYP_NEMVEDRAFT_V1G230495.1.1 m.61213 sp WBP2_HUMAN 53.211 109 47 4 1 106 1 108 1.08E-30 113 WBP2_HUMAN reviewed WW domain-binding protein 2 (WBP-2) WBP2 Homo sapiens (Human) 261 "cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization [GO:0045184]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000790; GO:0000979; GO:0001105; GO:0031490; GO:0045184; GO:0045815; GO:0045944; GO:0071391; GO:0071442 0 0 0 PF02893; Q96MM6 CHOYP_LOC100899882.2.3 m.34121 sp HS12B_HUMAN 30.109 641 372 14 40 620 61 685 1.08E-93 306 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96RW7 CHOYP_BRAFLDRAFT_88566.8.11 m.28560 sp HMCN1_HUMAN 46.784 342 182 0 46 387 4528 4869 1.08E-104 346 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96SN8 CHOYP_TVAG_268110.12.13 m.54210 sp CK5P2_HUMAN 29.252 441 249 12 32 420 35 464 1.08E-28 130 CK5P2_HUMAN reviewed CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) CDK5RAP2 CEP215 KIAA1633 Homo sapiens (Human) 1893 "brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome organization [GO:0051297]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of neuron differentiation [GO:0045664]; regulation of spindle checkpoint [GO:0090231]" GO:0000086; GO:0000132; GO:0000226; GO:0000242; GO:0000922; GO:0001578; GO:0005516; GO:0005737; GO:0005794; GO:0005813; GO:0005829; GO:0005856; GO:0005874; GO:0007059; GO:0007099; GO:0007420; GO:0008017; GO:0015631; GO:0019901; GO:0022008; GO:0030054; GO:0031023; GO:0035371; GO:0044212; GO:0045664; GO:0045665; GO:0045893; GO:0046600; GO:0048471; GO:0051297; GO:0070062; GO:0090231; GO:0097431 0 0 0 PF07989; Q96WV6 CHOYP_NEMVEDRAFT_V1G11719.1.1 m.31185 sp YHU2_SCHPO 25.532 94 70 0 2 95 593 686 1.08E-13 68.6 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q98SW2 CHOYP_LOC411534.2.2 m.52136 sp HIF1A_ONCMY 22.581 341 225 9 4 331 40 354 1.08E-17 91.3 HIF1A_ONCMY reviewed Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) hif1a Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 766 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005623; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016607 0 0 0 PF11413;PF08778;PF08447;PF13426; Q99M80 CHOYP_PTPRT.20.45 m.45507 sp PTPRT_MOUSE 32.136 557 334 14 438 968 738 1276 1.08E-68 254 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99NH0 CHOYP_LOC754728.5.6 m.42237 sp ANR17_MOUSE 30.095 525 310 16 219 729 204 685 1.08E-42 171 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BG99 CHOYP_TREX1.1.2 m.19782 sp TREX1_BOVIN 47.5 120 49 4 2 107 5 124 1.08E-22 92.4 TREX1_BOVIN reviewed Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) TREX1 Bos taurus (Bovine) 315 cell cycle [GO:0007049]; DNA metabolic process [GO:0006259] GO:0003676; GO:0005634; GO:0005789; GO:0005829; GO:0006259; GO:0007049; GO:0008296; GO:0008408; GO:0008853; GO:0046872 0 0 0 0 Q9C6B9 CHOYP_BRAFLDRAFT_118790.1.1 m.29970 sp PEAM3_ARATH 51.815 496 228 4 10 503 3 489 1.08E-178 513 PEAM3_ARATH reviewed Phosphoethanolamine N-methyltransferase 3 (EC 2.1.1.103) NMT3 At1g73600 F25P22.1 F6D5.1 Arabidopsis thaliana (Mouse-ear cress) 490 methylation [GO:0032259]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid biosynthetic process [GO:0008654] GO:0000234; GO:0005737; GO:0006656; GO:0008654; GO:0008757; GO:0032259 PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from phosphoethanolamine: step 1/1. 0 0 PF08241; Q9CZJ2 CHOYP_BRAFLDRAFT_208293.5.20 m.35589 sp HS12B_MOUSE 29.819 664 375 11 12 619 56 684 1.08E-90 298 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D024 CHOYP_LOC100371637.1.1 m.7833 sp CCD47_MOUSE 47.416 445 216 9 57 492 32 467 1.08E-138 411 CCD47_MOUSE reviewed Coiled-coil domain-containing protein 47 (Adipocyte-specific protein 4) Ccdc47 Asp4 Mus musculus (Mouse) 483 calcium ion homeostasis [GO:0055074]; endoplasmic reticulum organization [GO:0007029]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; ER overload response [GO:0006983]; osteoblast differentiation [GO:0001649]; post-embryonic development [GO:0009791] GO:0001649; GO:0005509; GO:0005783; GO:0005791; GO:0006983; GO:0007029; GO:0009791; GO:0016020; GO:0016021; GO:0030433; GO:0044822; GO:0055074 0 0 0 PF07946; Q9NPA5 CHOYP_LOC100376684.1.1 m.9998 sp ZF64A_HUMAN 42.4 375 202 7 135 507 102 464 1.08E-85 292 ZF64A_HUMAN reviewed "Zinc finger protein 64 homolog, isoforms 1 and 2 (Zfp-64) (Zinc finger protein 338)" ZFP64 ZNF338 Homo sapiens (Human) 681 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF13912; Q9NY47 CHOYP_NEMVEDRAFT_V1G240929.1.1 m.47629 sp CA2D2_HUMAN 23.766 993 578 35 47 981 77 948 1.08E-50 199 CA2D2_HUMAN reviewed Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] CACNA2D2 KIAA0558 Homo sapiens (Human) 1150 cardiac conduction [GO:0061337]; muscle fiber development [GO:0048747]; neuromuscular junction development [GO:0007528]; positive regulation of organ growth [GO:0046622]; regulation of insulin secretion [GO:0050796]; regulation of multicellular organism growth [GO:0040014]; rhythmic synaptic transmission [GO:0060024] GO:0005245; GO:0005886; GO:0005891; GO:0007528; GO:0040014; GO:0046622; GO:0046872; GO:0048747; GO:0050796; GO:0060024; GO:0061337 0 0 0 PF08473;PF00092;PF08399; Q9QXV3 CHOYP_ISCW_ISCW007158.2.2 m.53690 sp ING1_MOUSE 42.029 276 134 5 3 262 1 266 1.08E-63 203 ING1_MOUSE reviewed Inhibitor of growth protein 1 Ing1 Mus musculus (Mouse) 279 "cell cycle [GO:0007049]; chromatin modification [GO:0016568]; negative regulation of cell proliferation [GO:0008285]; positive regulation of transcription, DNA-templated [GO:0045893]; protein import into nucleus [GO:0006606]; regulation of cell death [GO:0010941]" GO:0005634; GO:0005654; GO:0005737; GO:0006606; GO:0007049; GO:0008270; GO:0008285; GO:0010941; GO:0016568; GO:0035064; GO:0045893 0 0 0 PF12998; Q9R0M3 CHOYP_BRAFLDRAFT_92090.6.7 m.65603 sp SRPX_MOUSE 24.823 282 179 10 62 315 89 365 1.08E-11 68.9 SRPX_MOUSE reviewed Sushi-repeat-containing protein SRPX (DRS protein) Srpx Mus musculus (Mouse) 464 autophagy [GO:0006914]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976] GO:0001845; GO:0005776; GO:0005783; GO:0006914; GO:0034976; GO:0060244; GO:2001241 0 0 0 PF13778;PF02494;PF00084; Q9U637 CHOYP_PITX.1.1 m.29315 sp PITX_BRABE 56.268 343 96 18 1 305 1 327 1.08E-93 284 PITX_BRABE reviewed Pituitary homeobox x (Bicoid type transcription factor Pitx) (BbPtx) (Homeobox protein Ptx) (Paired-like homeodomain transcription factor x) Ptx Branchiostoma belcheri (Amphioxus) 331 multicellular organism development [GO:0007275] GO:0003700; GO:0005634; GO:0007275; GO:0043565 0 0 0 PF00046;PF03826; Q9UBP9 CHOYP_LOC100648297.1.1 m.8606 sp GULP1_HUMAN 64.407 59 21 0 1 59 133 191 1.08E-18 86.7 GULP1_HUMAN reviewed PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) (Protein GULP) GULP1 CED6 GULP Homo sapiens (Human) 304 "apoptotic process [GO:0006915]; lipid transport [GO:0006869]; phagocytosis, engulfment [GO:0006911]" GO:0004871; GO:0005737; GO:0006869; GO:0006911; GO:0006915 0 0 0 PF00640; Q9UM13 CHOYP_LOC100642984.1.1 m.28915 sp APC10_HUMAN 59.459 185 75 0 1 185 1 185 1.08E-81 243 APC10_HUMAN reviewed Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10) ANAPC10 APC10 Homo sapiens (Human) 185 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005654; GO:0005680; GO:0005829; GO:0007067; GO:0008054; GO:0030071; GO:0031145; GO:0042787; GO:0043161; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256; Q9V5L3 CHOYP_BRAFLDRAFT_91871.1.3 m.931 sp C49A1_DROME 39.333 150 84 1 1 143 438 587 1.08E-32 124 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q9V5L3 CHOYP_CYP301B1.1.2 m.2254 sp C49A1_DROME 39.333 150 84 1 1 143 438 587 1.08E-32 124 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q9VAT2 CHOYP_RAB6B.1.1 m.24944 sp DCA10_DROME 41.641 329 177 2 13 326 4 332 1.08E-76 259 DCA10_DROME reviewed DDB1- and CUL4-associated factor 10 homolog (WD repeat-containing protein 32 homolog) CG1523 Drosophila melanogaster (Fruit fly) 621 0 0 0 0 0 PF00400; Q9VCA2 CHOYP_ORCT.2.6 m.28429 sp ORCT_DROME 36.197 547 298 9 1 522 1 521 1.08E-112 348 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9VCA8 CHOYP_LOC583072.23.25 m.59551 sp ANKHM_DROME 30.864 567 322 21 696 1239 488 1007 1.08E-46 188 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9X6U2 CHOYP_LOC100375141.1.1 m.12655 sp BDHA_CUPNH 41.379 261 148 3 2 261 2 258 1.08E-63 202 BDHA_CUPNH reviewed D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) hbdH1 H16_A1334 Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 258 0 GO:0003858 0 0 0 PF00106; A2AAY5 CHOYP_LOC100703439.1.1 m.52759 sp SPD2B_MOUSE 42.437 476 235 10 10 464 7 464 1.09E-111 371 SPD2B_MOUSE reviewed SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) Sh3pxd2b Fad49 Tks4 Mus musculus (Mouse) 908 adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; oxidation-reduction process [GO:0055114]; podosome assembly [GO:0071800]; positive regulation of fat cell differentiation [GO:0045600]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide metabolic process [GO:0006801] GO:0001501; GO:0001654; GO:0002102; GO:0005737; GO:0006801; GO:0007507; GO:0010314; GO:0016176; GO:0022617; GO:0030054; GO:0030154; GO:0032266; GO:0042169; GO:0042995; GO:0045600; GO:0055114; GO:0060348; GO:0060612; GO:0070273; GO:0071800; GO:0072657; GO:0080025 0 0 0 PF00787;PF00018;PF07653; A4IF63 CHOYP_LOC100369333.4.32 m.21269 sp TRIM2_BOVIN 28.436 211 140 6 385 590 540 744 1.09E-12 74.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_CARNS1.4.6 m.40244 sp CRNS1_HUMAN 36.483 836 505 12 123 941 1 827 1.09E-174 531 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A6BM72 CHOYP_MEG11.21.25 m.58585 sp MEG11_HUMAN 45.02 251 138 0 7 257 3 253 1.09E-64 222 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; B4IBI9 CHOYP_BRAFLDRAFT_124131.1.1 m.9889 sp SUR8_DROSE 29.604 429 287 5 41 457 165 590 1.09E-43 171 SUR8_DROSE reviewed Leucine-rich repeat protein soc-2 homolog (Protein Sur-8 homolog) (Protein soc-2 homolog) Sur-8 GM15368 Drosophila sechellia (Fruit fly) 683 0 0 0 0 0 PF00560;PF13306;PF13855; D3ZQG6 CHOYP_BRAFLDRAFT_75885.7.7 m.56204 sp TRIM2_RAT 30.37 135 62 4 8 118 22 148 1.09E-10 67.4 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E7FAM5 CHOYP_LOC100373888.5.9 m.39135 sp LIN41_DANRE 25.6 250 143 8 8 231 152 384 1.09E-07 58.5 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; F1N9Y5 CHOYP_LOC589201.1.1 m.59863 sp KSYK_CHICK 40.278 648 334 15 1 639 1 604 1.09E-157 470 KSYK_CHICK reviewed Tyrosine-protein kinase SYK (EC 2.7.10.2) SYK RCJMB04_19o18 Gallus gallus (Chicken) 613 adaptive immune response [GO:0002250]; B cell receptor signaling pathway [GO:0050853]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to molecule of fungal origin [GO:0071226]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; leukocyte activation involved in immune response [GO:0002366]; leukocyte cell-cell adhesion [GO:0007159]; lymph vessel development [GO:0001945]; macrophage activation involved in immune response [GO:0002281]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of mast cell degranulation [GO:0043306]; protein phosphorylation [GO:0006468]; regulation of arachidonic acid secretion [GO:0090237]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of neutrophil degranulation [GO:0043313]; regulation of phagocytosis [GO:0050764]; regulation of platelet activation [GO:0010543]; regulation of platelet aggregation [GO:0090330]; regulation of superoxide anion generation [GO:0032928]; serotonin secretion by platelet [GO:0002554]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001945; GO:0002250; GO:0002281; GO:0002283; GO:0002366; GO:0002554; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005829; GO:0006468; GO:0006954; GO:0007159; GO:0007169; GO:0007229; GO:0010543; GO:0018108; GO:0030154; GO:0030593; GO:0031234; GO:0032009; GO:0032928; GO:0033630; GO:0035556; GO:0038083; GO:0042742; GO:0043306; GO:0043313; GO:0045087; GO:0045579; GO:0045780; GO:0046641; GO:0048514; GO:0050764; GO:0050853; GO:0070301; GO:0070372; GO:0071226; GO:0090237; GO:0090330 0 0 0 PF07714;PF00017; O09164 CHOYP_COX1.11.15 m.50553 sp SODE_MOUSE 26.415 159 99 5 4 148 75 229 1.09E-08 55.5 SODE_MOUSE reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) Sod3 Mus musculus (Mouse) 251 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to reactive oxygen species [GO:0000302] GO:0000302; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005796; GO:0005802; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; O14733 CHOYP_MP2K7.2.2 m.24268 sp MP2K7_HUMAN 72.524 313 86 0 123 435 85 397 1.09E-167 480 MP2K7_HUMAN reviewed Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 Homo sapiens (Human) 419 activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular response to sorbitol [GO:0072709]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; proteolysis in other organism [GO:0035897]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403] GO:0000287; GO:0004702; GO:0004708; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0006970; GO:0007165; GO:0007254; GO:0007257; GO:0008545; GO:0009408; GO:0009411; GO:0019899; GO:0019901; GO:0019903; GO:0032212; GO:0034612; GO:0035897; GO:0038095; GO:0043525; GO:0051403; GO:0051973; GO:0072709; GO:1904355 0 0 0 PF00069; O15034 CHOYP_RIMB2.5.5 m.64082 sp RIMB2_HUMAN 37.634 465 237 10 978 1434 167 586 1.09E-75 278 RIMB2_HUMAN reviewed RIMS-binding protein 2 (RIM-BP2) RIMBP2 KIAA0318 RBP2 Homo sapiens (Human) 1052 negative regulation of phosphatase activity [GO:0010923] GO:0005886; GO:0010923; GO:0030054; GO:0045202 0 0 0 PF07653;PF14604; O42387 CHOYP_PARG.1.1 m.24814 sp RS24_TAKRU 79.528 127 26 0 5 131 4 130 1.09E-71 213 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O43915 CHOYP_AFG32.1.1 m.59373 sp VEGFD_HUMAN 26.633 199 124 6 19 204 46 235 1.09E-07 56.6 VEGFD_HUMAN reviewed Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) FIGF VEGFD Homo sapiens (Human) 354 angiogenesis [GO:0001525]; cell proliferation [GO:0008283]; dopaminergic neuron differentiation [GO:0071542]; induction of positive chemotaxis [GO:0050930]; platelet degranulation [GO:0002576]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001666; GO:0002576; GO:0005161; GO:0005172; GO:0005576; GO:0005615; GO:0008283; GO:0008284; GO:0016020; GO:0030947; GO:0031093; GO:0032755; GO:0042056; GO:0048010; GO:0050930; GO:0051781; GO:0060754; GO:0070555; GO:0071542 0 0 0 PF00341; O70277 CHOYP_BRAFLDRAFT_110072.6.8 m.32824 sp TRIM3_RAT 21.681 226 164 4 301 515 488 711 1.09E-08 61.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O73791 CHOYP_MEGF11.1.11 m.5806 sp TIE2_DANRE 34.899 149 60 10 58 185 218 350 1.09E-13 72.4 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O75382 CHOYP_CPIPJ_CPIJ001613.1.3 m.31475 sp TRIM3_HUMAN 25.155 322 183 13 7 296 12 307 1.09E-13 78.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P01130 CHOYP_LDLR.1.7 m.14683 sp LDLR_HUMAN 53.333 75 33 2 54 127 72 145 1.09E-17 80.9 LDLR_HUMAN reviewed Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899] GO:0001618; GO:0001948; GO:0002020; GO:0004872; GO:0005041; GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005887; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0008203; GO:0009897; GO:0009986; GO:0010008; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0030669; GO:0032050; GO:0034362; GO:0034383; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0070508; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P03934 CHOYP_PMAR_PMAR021704.1.1 m.52925 sp TC1A_CAEEL 38.115 244 147 4 95 337 33 273 1.09E-46 162 TC1A_CAEEL reviewed Transposable element Tc1 transposase tc1a tca T07D3.8 Caenorhabditis elegans 273 "developmental process [GO:0032502]; DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0004519; GO:0005634; GO:0006313; GO:0015074; GO:0032502 0 0 0 PF01498; P10079 CHOYP_LOC100632098.6.13 m.38430 sp FBP1_STRPU 57.237 152 65 0 1 152 294 445 1.09E-50 176 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P14099 CHOYP_PDE2A.1.3 m.23227 sp PDE2A_BOVIN 28.251 223 131 8 8 213 28 238 1.09E-13 72.8 PDE2A_BOVIN reviewed "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" PDE2A Bos taurus (Bovine) 921 "cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to drug [GO:0035690]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; GMP catabolic process [GO:0046038]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of protein import into nucleus, translocation [GO:0033159]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; protein targeting to mitochondrion [GO:0006626]; regulation of cAMP metabolic process [GO:0030814]; signal transduction [GO:0007165]" GO:0000122; GO:0004112; GO:0004118; GO:0005634; GO:0005737; GO:0005759; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006198; GO:0006626; GO:0007165; GO:0008144; GO:0019933; GO:0019934; GO:0030553; GO:0030814; GO:0030818; GO:0033159; GO:0035690; GO:0036006; GO:0042734; GO:0043116; GO:0043117; GO:0046038; GO:0046069; GO:0046872; GO:0048471; GO:0050729; GO:0061028; GO:0071260; GO:0071321; GO:0097011 0 0 0 PF01590;PF13185;PF00233; P16157 CHOYP_LOC100639010.2.9 m.31858 sp ANK1_HUMAN 31.856 361 233 2 3 354 138 494 1.09E-52 191 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_067900.5.7 m.32664 sp ANK1_HUMAN 34.146 287 172 4 760 1031 210 494 1.09E-34 148 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17810 CHOYP_LOC100369131.2.2 m.48868 sp PRPH2_BOVIN 25.926 297 202 6 5 285 5 299 1.09E-38 142 PRPH2_BOVIN reviewed Peripherin-2 (Retinal degeneration slow protein) PRPH2 RDS Bos taurus (Bovine) 345 cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; visual perception [GO:0007601] GO:0005887; GO:0007155; GO:0007166; GO:0007601 0 0 0 PF00335; P18503 CHOYP_BRAFLDRAFT_76550.21.21 m.66527 sp CAS4_EPHMU 32.231 121 68 3 91 211 207 313 1.09E-06 52.8 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P20825 CHOYP_LOC587827.1.4 m.13601 sp POL2_DROME 36.204 511 275 8 422 917 148 622 1.09E-93 322 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P25067 CHOYP_LOC100497959.1.1 m.21718 sp CO8A2_HUMAN 35.185 108 63 3 76 181 574 676 1.09E-09 60.8 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; P32029 CHOYP_LOC100313608.1.1 m.9371 sp FD5_DROME 33.023 215 119 5 90 301 13 205 1.09E-27 114 FD5_DROME reviewed Fork head domain-containing protein FD5 fd96Cb FD5 CG11922 Drosophila melanogaster (Fruit fly) 271 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0005634; GO:0006351; GO:0007275; GO:0043565 0 0 0 PF00250; P41436 CHOYP_BIR7B.2.2 m.60973 sp IAP_GVCPM 39.655 174 98 3 31 199 5 176 1.09E-40 147 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P49109 CHOYP_FMO4.1.1 m.9841 sp FMO5_CAVPO 42.486 539 285 7 3 529 4 529 1.09E-155 458 FMO5_CAVPO reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; P50225 CHOYP_GM766.1.1 m.19916 sp ST1A1_HUMAN 31.429 280 165 6 32 290 19 292 1.09E-43 153 ST1A1_HUMAN reviewed Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) SULT1A1 STP STP1 OK/SW-cl.88 Homo sapiens (Human) 295 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; estrogen metabolic process [GO:0008210]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005829; GO:0006584; GO:0006805; GO:0008146; GO:0008202; GO:0008210; GO:0009308; GO:0009812; GO:0047894; GO:0050294; GO:0050427; GO:0051923 0 0 0 PF00685; P51423 CHOYP_UBIQP.4.13 m.19915 sp RL40_BRARP 44.737 76 39 1 2 77 26 98 1.09E-11 59.7 RL40_BRARP reviewed Ubiquitin-60S ribosomal protein L40 [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (CEP52)] 0 Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis) 128 translation [GO:0006412] GO:0003735; GO:0005634; GO:0005840; GO:0006412 0 0 0 PF01020;PF00240; P52917 CHOYP_LOC100368955.1.1 m.48500 sp VPS4_YEAST 43.782 386 195 7 50 422 60 436 1.09E-101 312 VPS4_YEAST reviewed Vacuolar protein sorting-associated protein 4 (DOA4-independent degradation protein 6) (Protein END13) (Vacuolar protein-targeting protein 10) VPS4 CSC1 DID6 END13 GRD13 VPL4 VPT10 YPR173C P9705.10 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 437 intralumenal vesicle formation [GO:0070676]; late endosome to vacuole transport [GO:0045324]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]; macroautophagy [GO:0016236]; protein homooligomerization [GO:0051260]; protein retention in Golgi apparatus [GO:0045053]; protein transport [GO:0015031]; sterol metabolic process [GO:0016125]; vacuole organization [GO:0007033] GO:0005524; GO:0005634; GO:0005768; GO:0007033; GO:0015031; GO:0016020; GO:0016125; GO:0016236; GO:0016887; GO:0032511; GO:0042802; GO:0042803; GO:0045053; GO:0045324; GO:0051260; GO:0070676; GO:1990621 0 0 0 PF00004;PF04212;PF09336; P62484 CHOYP_LOC100372094.1.1 m.16454 sp ABI2_MOUSE 66.667 78 21 1 48 125 370 442 1.09E-28 111 ABI2_MOUSE reviewed Abl interactor 2 (Abelson interactor 2) (Abi-2) Abi2 Mus musculus (Mouse) 446 actin polymerization or depolymerization [GO:0008154]; camera-type eye development [GO:0043010]; cell migration [GO:0016477]; dendrite development [GO:0016358]; learning or memory [GO:0007611]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; Rac protein signal transduction [GO:0016601] GO:0005829; GO:0005856; GO:0005913; GO:0007611; GO:0008154; GO:0016358; GO:0016477; GO:0016601; GO:0017124; GO:0018108; GO:0030027; GO:0030175; GO:0030425; GO:0031209; GO:0031625; GO:0032403; GO:0043010; GO:0070064; GO:2000601 0 0 0 PF07815;PF14604; P62489 CHOYP_LOC100370989.2.2 m.37995 sp RPB7_RAT 87.195 164 21 0 9 172 1 164 1.09E-105 302 RPB7_RAT reviewed DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) Polr2g Rattus norvegicus (Rat) 172 "apoptotic process [GO:0006915]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translational initiation [GO:0045948]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000291; GO:0000932; GO:0003697; GO:0003727; GO:0003899; GO:0005634; GO:0005665; GO:0006366; GO:0006367; GO:0006915; GO:0031369; GO:0045948; GO:0060213 0 0 0 PF00575;PF03876; P70196 CHOYP_LOC101161428.1.1 m.52158 sp TRAF6_MOUSE 30.159 126 78 4 140 261 125 244 1.09E-10 67.8 TRAF6_MOUSE reviewed TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) Traf6 Mus musculus (Mouse) 530 "activation of NF-kappaB-inducing kinase activity [GO:0007250]; activation of protein kinase activity [GO:0032147]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; bone remodeling [GO:0046849]; bone resorption [GO:0045453]; cell development [GO:0048468]; cellular response to lipopolysaccharide [GO:0071222]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; immune response [GO:0006955]; interleukin-1-mediated signaling pathway [GO:0070498]; JNK cascade [GO:0007254]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; organ morphogenesis [GO:0009887]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-12 biosynthetic process [GO:0045084]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein autoubiquitination [GO:0051865]; protein complex assembly [GO:0006461]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of immunoglobulin secretion [GO:0051023]; response to interleukin-1 [GO:0070555]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]" GO:0000122; GO:0000209; GO:0001503; GO:0001843; GO:0002726; GO:0004842; GO:0004871; GO:0005164; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005811; GO:0005829; GO:0005886; GO:0005938; GO:0006461; GO:0006955; GO:0007165; GO:0007249; GO:0007250; GO:0007254; GO:0008270; GO:0009887; GO:0009898; GO:0016567; GO:0016874; GO:0019886; GO:0019901; GO:0030316; GO:0031435; GO:0031624; GO:0031625; GO:0031666; GO:0031996; GO:0032147; GO:0032743; GO:0035631; GO:0042088; GO:0042102; GO:0042475; GO:0042802; GO:0042826; GO:0043011; GO:0043065; GO:0043123; GO:0043234; GO:0043422; GO:0043507; GO:0045084; GO:0045410; GO:0045453; GO:0045672; GO:0045892; GO:0045944; GO:0046849; GO:0047485; GO:0048468; GO:0048471; GO:0048661; GO:0050852; GO:0051023; GO:0051091; GO:0051092; GO:0051865; GO:0061630; GO:0070498; GO:0070534; GO:0070555; GO:0071222; GO:2000679 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02176; P82094 CHOYP_TMF1.1.1 m.52858 sp TMF1_HUMAN 47.287 645 324 9 674 1312 454 1088 1.09E-163 521 TMF1_HUMAN reviewed TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) TMF1 ARA160 Homo sapiens (Human) 1093 "acrosome assembly [GO:0001675]; cellular response to organic cyclic compound [GO:0071407]; defense response to bacterium [GO:0042742]; Leydig cell differentiation [GO:0033327]; luteinizing hormone secretion [GO:0032275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; positive regulation of cytokine production [GO:0001819]; positive regulation of testosterone secretion [GO:2000845]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of transcription, DNA-templated [GO:0006355]; spermatid nucleus differentiation [GO:0007289]; sperm motility [GO:0030317]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000139; GO:0001675; GO:0001819; GO:0003677; GO:0003712; GO:0005634; GO:0005783; GO:0005794; GO:0005829; GO:0006355; GO:0006366; GO:0007289; GO:0010629; GO:0030317; GO:0032275; GO:0033327; GO:0042742; GO:0043066; GO:0061136; GO:0071407; GO:2000845 0 0 0 PF12329;PF12325; P82596 CHOYP_BRAFLDRAFT_80760.1.1 m.28956 sp PLC_HALLA 35.556 135 78 4 21 154 2 128 1.09E-20 85.9 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q12802 CHOYP_LOC100367382.1.1 m.34764 sp AKP13_HUMAN 32.889 225 143 5 1 221 1 221 1.09E-23 112 AKP13_HUMAN reviewed A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) 2813 adrenergic receptor signaling pathway [GO:0071875]; adrenergic receptor signaling pathway involved in heart process [GO:0086023]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; nuclear export [GO:0051168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cardiac muscle hypertrophy [GO:0010611]; regulation of glucocorticoid mediated signaling pathway [GO:1900169]; regulation of protein kinase activity [GO:0045859]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004691; GO:0004871; GO:0005078; GO:0005085; GO:0005089; GO:0005634; GO:0005737; GO:0005829; GO:0005938; GO:0007186; GO:0007507; GO:0010611; GO:0016020; GO:0017048; GO:0032947; GO:0035025; GO:0035556; GO:0043065; GO:0043123; GO:0045859; GO:0046872; GO:0048471; GO:0051018; GO:0051056; GO:0051168; GO:0055007; GO:0060297; GO:0060348; GO:0071875; GO:0086023; GO:1900169 0 0 0 PF00169;PF00621;PF10522; Q13332 CHOYP_BRAFLDRAFT_79792.1.2 m.3518 sp PTPRS_HUMAN 21.296 324 192 11 181 450 541 855 1.09E-08 61.6 PTPRS_HUMAN reviewed Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) PTPRS Homo sapiens (Human) 1948 cell adhesion [GO:0007155]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; corpus callosum development [GO:0022038]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; spinal cord development [GO:0021510] GO:0005001; GO:0005886; GO:0005887; GO:0007155; GO:0007268; GO:0021510; GO:0021549; GO:0021766; GO:0021987; GO:0022038; GO:0070062; GO:0090557 0 0 0 PF00041;PF07679;PF00102; Q14678 CHOYP_LOC100538765.1.1 m.50821 sp KANK1_HUMAN 56.571 175 76 0 1 175 1125 1299 1.09E-56 195 KANK1_HUMAN reviewed KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) KANK1 ANKRD15 KANK KIAA0172 Homo sapiens (Human) 1352 "negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell migration [GO:0030336]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lamellipodium morphogenesis [GO:2000393]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of establishment of cell polarity [GO:2000114]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0008013; GO:0010977; GO:0030177; GO:0030336; GO:0030837; GO:0032587; GO:0035024; GO:0035413; GO:0046627; GO:0090303; GO:1900025; GO:1900028; GO:2000114; GO:2000393 0 0 0 PF12796;PF12075; Q16981 CHOYP_APLC.1.2 m.1245 sp NCS1_APLCA 82.738 168 29 0 13 180 23 190 1.09E-101 293 NCS1_APLCA reviewed Neuronal calcium sensor 1 (NCS-1) (Aplycalcin) 0 Aplysia californica (California sea hare) 191 0 GO:0005509 0 0 0 PF00036;PF13499; Q1RMP0 CHOYP_ZNRD1.2.2 m.66833 sp RPA12_BOVIN 49.425 87 43 1 6 91 8 94 1.09E-27 100 RPA12_BOVIN reviewed DNA-directed RNA polymerase I subunit RPA12 (Zinc ribbon domain-containing protein 1) ZNRD1 Bos taurus (Bovine) 123 termination of RNA polymerase I transcription [GO:0006363] GO:0003676; GO:0003899; GO:0005736; GO:0006363; GO:0008270 0 0 0 PF01096; Q26481 CHOYP_CLK2.1.1 m.3083 sp RL5_STYCL 76.271 295 69 1 1 295 1 294 1.09E-169 474 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q26481 CHOYP_LOC100372626.1.2 m.8347 sp RL5_STYCL 76.271 295 69 1 1 295 1 294 1.09E-169 474 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q28C22 CHOYP_LOC752784.2.2 m.64511 sp OGFD2_XENTR 47.093 344 137 4 16 318 9 348 1.09E-109 325 OGFD2_XENTR reviewed 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-) ogfod2 TEgg127j14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 349 0 GO:0005506; GO:0016705; GO:0031418; GO:0051213 0 0 0 0 Q3MHZ8 CHOYP_BRAFLDRAFT_126856.2.3 m.30577 sp LEG9_BOVIN 37.845 362 185 10 2 338 8 354 1.09E-65 214 LEG9_BOVIN reviewed Galectin-9 (Gal-9) LGALS9 Bos taurus (Bovine) 355 immune system process [GO:0002376] GO:0002376; GO:0005576; GO:0005634; GO:0005737; GO:0030246 0 0 0 PF00337; Q3T075 CHOYP_RFNG.1.1 m.34922 sp STX8_BOVIN 46.083 217 112 3 1 214 1 215 1.09E-52 173 STX8_BOVIN reviewed Syntaxin-8 STX8 Bos taurus (Bovine) 236 early endosome to late endosome transport [GO:0045022]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000149; GO:0005484; GO:0005769; GO:0005770; GO:0005802; GO:0005829; GO:0006886; GO:0006906; GO:0012505; GO:0016021; GO:0019869; GO:0031201; GO:0031982; GO:0045022; GO:0048278; GO:0048471; GO:0055037; GO:1903076 0 0 0 PF05739; Q3ZBD3 CHOYP_LOC100377460.1.1 m.38781 sp PHS_BOVIN 65.657 99 34 0 50 148 2 100 1.09E-43 142 PHS_BOVIN reviewed Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD) PCBD1 Bos taurus (Bovine) 104 "protein heterooligomerization [GO:0051291]; protein homotetramerization [GO:0051289]; regulation of transcription, DNA-templated [GO:0006355]; tetrahydrobiopterin biosynthetic process [GO:0006729]; transcription, DNA-templated [GO:0006351]" GO:0004505; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0006729; GO:0008124; GO:0051289; GO:0051291; GO:0070062 0 0 0 PF01329; Q40588 CHOYP_LOC100206475.8.16 m.43998 sp ASO_TOBAC 33.333 279 143 8 108 371 50 300 1.09E-34 140 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q4LDE5 CHOYP_LOC100367084.22.22 m.64849 sp SVEP1_HUMAN 24.312 872 476 35 48 775 329 1160 1.09E-33 146 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4R6H1 CHOYP_LOC100695358.1.1 m.63066 sp NDUAD_MACFA 44.628 121 62 2 26 145 18 134 1.09E-24 97.8 NDUAD_MACFA reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Complex I-B16.6) (CI-B16.6) (NADH-ubiquinone oxidoreductase B16.6 subunit) NDUFA13 QtsA-18051 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 163 "apoptotic signaling pathway [GO:0097190]; negative regulation of cell growth [GO:0030308]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of transcription, DNA-templated [GO:0045892]; reactive oxygen species metabolic process [GO:0072593]" GO:0003954; GO:0005654; GO:0005737; GO:0005739; GO:0005746; GO:0005747; GO:0008137; GO:0016021; GO:0030308; GO:0031966; GO:0045892; GO:0072593; GO:0097190; GO:2001243 0 0 0 PF06212; Q4ZJM9 CHOYP_C1QL4.6.10 m.39195 sp C1QL4_MOUSE 31.858 113 71 3 7 117 106 214 1.09E-07 51.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q567B1 CHOYP_BRAFLDRAFT_277775.1.1 m.12737 sp OTU1_DANRE 51.485 303 144 1 6 308 2 301 1.09E-108 320 OTU1_DANRE reviewed Ubiquitin thioesterase OTU1 (EC 3.4.19.12) yod1 zgc:112182 Danio rerio (Zebrafish) (Brachydanio rerio) 301 endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536] GO:0004843; GO:0030433; GO:0030968; GO:0035523; GO:0035871; GO:0046872; GO:0070536; GO:0071108; GO:1990167; GO:1990168 0 0 0 PF02338;PF14560; Q569T7 CHOYP_BRAFLDRAFT_85464.1.2 m.40595 sp MFS4B_XENLA 41.096 146 86 0 49 194 1 146 1.09E-32 136 MFS4B_XENLA reviewed Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) mfsd4b naglt1 Xenopus laevis (African clawed frog) 491 carbohydrate transport [GO:0008643]; sodium ion transport [GO:0006814] GO:0006814; GO:0008643; GO:0015293; GO:0016021; GO:0016324 0 0 cd06174; PF07690; Q58DA1 CHOYP_SPEF1.1.4 m.20911 sp SPEF1_BOVIN 37.395 238 116 6 18 236 1 224 1.09E-44 153 SPEF1_BOVIN reviewed Sperm flagellar protein 1 SPEF1 Bos taurus (Bovine) 236 0 GO:0005737; GO:0005930; GO:0031514 0 0 0 PF06294; Q58DQ5 CHOYP_AAEL_AAEL011391.1.1 m.10090 sp RT09_BOVIN 33.333 393 229 6 20 405 30 396 1.09E-59 202 RT09_BOVIN reviewed "28S ribosomal protein S9, mitochondrial (MRP-S9) (S9mt)" MRPS9 Bos taurus (Bovine) 396 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124]; translation [GO:0006412]" GO:0000462; GO:0003735; GO:0005730; GO:0005743; GO:0005763; GO:0006412; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF00380; Q5ND28 CHOYP_LOC100182840.1.4 m.4446 sp SREC_MOUSE 38.824 170 96 6 193 360 215 378 1.09E-23 105 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RJ80 CHOYP_TVAG_037540.1.1 m.40756 sp CAPR2_DANRE 32.593 135 80 6 209 340 786 912 1.09E-07 57 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5THR3 CHOYP_BRAFLDRAFT_117976.3.3 m.66744 sp EFCB6_HUMAN 28.571 196 130 3 102 295 1309 1496 1.09E-17 87 EFCB6_HUMAN reviewed EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) 1501 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q5VY43 CHOYP_LOC575944.4.5 m.31459 sp PEAR1_HUMAN 33.086 405 232 19 159 550 438 816 1.09E-40 161 PEAR1_HUMAN reviewed Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) PEAR1 MEGF12 Homo sapiens (Human) 1037 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q5XJQ7 CHOYP_LOC100559685.1.1 m.27690 sp OSR1_DANRE 61.932 176 45 5 154 328 110 264 1.09E-63 206 OSR1_DANRE reviewed Protein odd-skipped-related 1 (zOsr1) osr1 si:dkey-199e17.1 zgc:101674 Danio rerio (Zebrafish) (Brachydanio rerio) 264 "angioblast cell differentiation [GO:0035779]; glomerular visceral epithelial cell differentiation [GO:0072112]; intermediate mesoderm development [GO:0048389]; kidney development [GO:0001822]; mesendoderm development [GO:0048382]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pectoral fin development [GO:0033339]; pronephric distal tubule development [GO:0035777]; pronephric glomerulus morphogenesis [GO:0035775]; pronephric nephron tubule epithelial cell differentiation [GO:0035778]; pronephric proximal tubule development [GO:0035776]; pronephros development [GO:0048793]; regulation of endodermal cell differentiation [GO:1903224]; regulation of nodal signaling pathway [GO:1900107]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001822; GO:0003676; GO:0005634; GO:0006351; GO:0033339; GO:0035775; GO:0035776; GO:0035777; GO:0035778; GO:0035779; GO:0045892; GO:0046872; GO:0048382; GO:0048389; GO:0048793; GO:0072112; GO:1900107; GO:1903224 0 0 0 0 Q62417 CHOYP_LOC100875671.1.1 m.57087 sp SRBS1_MOUSE 42.231 251 114 8 491 731 980 1209 1.09E-44 179 SRBS1_MOUSE reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Sorbs1 Kiaa1296 Sh3d5 Mus musculus (Mouse) 1290 cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005856; GO:0005886; GO:0005913; GO:0005924; GO:0005925; GO:0008134; GO:0008286; GO:0015758; GO:0016020; GO:0016363; GO:0019901; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q641Z2 CHOYP_LOC100883586.1.1 m.268 sp PTN9_RAT 53.268 306 143 0 399 704 276 581 1.09E-106 340 PTN9_RAT reviewed Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) Ptpn9 Rattus norvegicus (Rat) 593 0 GO:0004725; GO:0005737 0 0 0 PF00650;PF00102; Q68EK2 CHOYP_CALCR.5.6 m.49190 sp CALRL_DANRE 35.793 271 159 6 4 269 144 404 1.09E-43 159 CALRL_DANRE reviewed Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrla calcrl si:dkey-249o24.2 zgc:100872 Danio rerio (Zebrafish) (Brachydanio rerio) 470 angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; cell surface receptor signaling pathway [GO:0007166]; somitogenesis [GO:0001756] GO:0001525; GO:0001756; GO:0004948; GO:0005886; GO:0007166; GO:0016021; GO:0048844 0 0 0 PF00002;PF02793; Q6AZB8 CHOYP_LOC100491442.1.2 m.5783 sp HARB1_DANRE 45.556 90 49 0 8 97 221 310 1.09E-24 99.4 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6DHQ1 CHOYP_HVCN1.3.4 m.38779 sp HVCN1_DANRE 30.769 130 85 2 156 285 104 228 1.09E-13 73.2 HVCN1_DANRE reviewed Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) hvcn1 zgc:92181 Danio rerio (Zebrafish) (Brachydanio rerio) 235 cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transport [GO:0015992] GO:0005887; GO:0015992; GO:0030171; GO:0071294; GO:0071467 0 0 0 PF00520; Q6GMK6 CHOYP_TSN9.1.1 m.45709 sp TSN9_DANRE 28.829 222 146 4 11 224 9 226 1.09E-23 98.2 TSN9_DANRE reviewed Tetraspanin-9 (Tspan-9) tspan9 si:ch73-161g10.1 si:dkey-153k10.10 wu:fj18d05 zgc:91880 Danio rerio (Zebrafish) (Brachydanio rerio) 239 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q6KEQ9 CHOYP_PC11Y.1.1 m.7194 sp PC11X_PIG 34.635 768 466 19 12 762 11 759 1.09E-119 400 PC11X_PIG reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) PCDH11X PCDH11 PCDHX Sus scrofa (Pig) 1117 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q6TFL4 CHOYP_KLH12.3.3 m.66333 sp KLH24_HUMAN 28.675 551 361 9 32 576 66 590 1.09E-66 231 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q7TPV2 CHOYP_DZIP3.1.1 m.32292 sp DZIP3_MOUSE 31.915 94 57 2 63 149 452 545 1.09E-07 57 DZIP3_MOUSE reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) 1204 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q7TQ69 CHOYP_TMC3.1.1 m.4078 sp TMC3_MOUSE 29.549 731 413 20 104 749 52 765 1.09E-85 296 TMC3_MOUSE reviewed Transmembrane channel-like protein 3 Tmc3 Mus musculus (Mouse) 1130 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q7ZWE9 CHOYP_KCY.1.1 m.29973 sp KCY_DANRE 63.351 191 65 1 3 188 2 192 1.09E-80 241 KCY_DANRE reviewed UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) cmpk cmpk1 Danio rerio (Zebrafish) (Brachydanio rerio) 196 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142]; pyrimidine nucleotide biosynthetic process [GO:0006221] GO:0004127; GO:0004550; GO:0005524; GO:0005634; GO:0005737; GO:0006165; GO:0006207; GO:0006221; GO:0009041; GO:0009142 0 0 cd01428; 0 Q80TL4 CHOYP_K1045.1.2 m.27129 sp PHF24_MOUSE 28.517 263 164 7 97 340 133 390 1.09E-24 106 PHF24_MOUSE reviewed PHD finger protein 24 Phf24 Kiaa1045 N28178 Mus musculus (Mouse) 400 0 GO:0005509 0 0 0 PF16744; Q8BGA5 CHOYP_KRR1.1.1 m.11049 sp KRR1_MOUSE 68.955 335 104 0 13 347 24 358 1.09E-162 462 KRR1_MOUSE reviewed KRR1 small subunit processome component homolog (HIV-1 Rev-binding protein 2 homolog) (KRR-R motif-containing protein 1) Krr1 Hrb2 Mus musculus (Mouse) 380 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" GO:0000462; GO:0005634; GO:0005730; GO:0005737; GO:0016020; GO:0032040; GO:0044822; GO:0045171 0 0 0 0 Q8BHA1 CHOYP_BRAFLDRAFT_85492.1.1 m.48497 sp LRC24_MOUSE 26.471 306 185 6 21 315 27 303 1.09E-21 102 LRC24_MOUSE reviewed Leucine-rich repeat-containing protein 24 Lrrc24 Mus musculus (Mouse) 521 positive regulation of synapse assembly [GO:0051965] GO:0016021; GO:0051965 0 0 0 PF13855; Q8BIE6 CHOYP_LOC100369109.2.2 m.64295 sp FRM4A_MOUSE 50 548 231 5 81 626 1 507 1.09E-175 548 FRM4A_MOUSE reviewed FERM domain-containing protein 4A Frmd4a Frmd4 Kiaa1294 Mus musculus (Mouse) 1020 establishment of epithelial cell polarity [GO:0090162] GO:0005737; GO:0005856; GO:0005923; GO:0030674; GO:0090162 0 0 0 PF11819;PF09380;PF00373;PF09379; Q8BYH3 CHOYP_BRAFLDRAFT_285163.1.1 m.52380 sp TRM13_MOUSE 39.752 322 175 3 16 321 54 372 1.09E-72 238 TRM13_MOUSE reviewed tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) Trmt13 Ccdc76 Mus musculus (Mouse) 481 tRNA methylation [GO:0030488] GO:0008175; GO:0030488; GO:0046872 0 0 0 PF05206;PF11722;PF05253; Q8C7M3 CHOYP_BRAFLDRAFT_255103.7.18 m.34577 sp TRIM9_MOUSE 30.392 102 62 4 5 97 160 261 1.09E-06 52.4 TRIM9_MOUSE reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) Trim9 Kiaa0282 Mus musculus (Mouse) 817 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; synaptic vesicle exocytosis [GO:0016079] GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016079; GO:0016874; GO:0030054; GO:0030425; GO:0042803; GO:0043161 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643; Q8IVG5 CHOYP_SAMD9L.1.1 m.29234 sp SAM9L_HUMAN 26.087 299 189 12 12 294 1298 1580 1.09E-12 73.2 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8IYB1 CHOYP_LOC100377009.8.10 m.59764 sp M21D2_HUMAN 24.299 214 148 5 178 389 210 411 1.09E-13 77 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8IZJ3 CHOYP_DVIR_GJ18688.1.1 m.48622 sp CPMD8_HUMAN 29.767 215 118 10 130 330 917 1112 1.09E-09 65.9 CPMD8_HUMAN reviewed C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) 1885 0 GO:0004867; GO:0005615; GO:0005886 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF07648;PF12248;PF10569; Q8K480 CHOYP_MFRP.1.1 m.55294 sp MFRP_MOUSE 34.959 123 71 4 88 203 299 419 1.09E-12 72.8 MFRP_MOUSE reviewed Membrane frizzled-related protein (Membrane-type frizzled-related protein) Mfrp Mus musculus (Mouse) 584 eye photoreceptor cell development [GO:0042462]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] GO:0007601; GO:0016021; GO:0016324; GO:0042462; GO:0060041 0 0 0 PF00431;PF01392;PF00057; Q8N2E2 CHOYP_EEF2.2.2 m.54905 sp VWDE_HUMAN 32.872 289 152 13 220 502 1334 1586 1.09E-19 99 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NEA6 CHOYP_LOC100074304.1.1 m.27868 sp GLIS3_HUMAN 60.481 291 90 7 473 743 334 619 1.09E-105 347 GLIS3_HUMAN reviewed Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515) GLIS3 ZNF515 Homo sapiens (Human) 775 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0003677; GO:0005634; GO:0005654; GO:0005794; GO:0006366; GO:0045944; GO:0046872 0 0 0 0 Q8WZ64 CHOYP_LOC100639879.1.1 m.38832 sp ARAP2_HUMAN 27.835 1164 717 31 613 1727 454 1543 1.09E-112 399 ARAP2_HUMAN reviewed "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)" ARAP2 CENTD1 KIAA0580 Homo sapiens (Human) 1704 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005547; GO:0005829; GO:0007165; GO:0046872; GO:0051056 0 0 0 PF01412;PF00169;PF00788;PF00620;PF00536; Q8WZA0 CHOYP_EEF2.1.2 m.44025 sp LZIC_HUMAN 66.667 189 63 0 8 196 2 190 1.09E-86 256 LZIC_HUMAN reviewed Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein) LZIC Homo sapiens (Human) 190 response to ionizing radiation [GO:0010212] GO:0010212 0 0 0 PF06384; Q90511 CHOYP_LOC100367093.1.1 m.63664 sp EI2BB_TAKRU 61.111 360 129 6 13 366 1 355 1.09E-157 449 EI2BB_TAKRU reviewed Translation initiation factor eIF-2B subunit beta (S20I15) (eIF-2B GDP-GTP exchange factor subunit beta) eif2b2 eif2bb Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 355 cellular response to stimulus [GO:0051716]; central nervous system development [GO:0007417]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0003743; GO:0005085; GO:0005524; GO:0005525; GO:0005737; GO:0005851; GO:0006413; GO:0006446; GO:0007417; GO:0014003; GO:0042552; GO:0051716 0 0 0 PF01008; Q90YS3 CHOYP_RS2.7.10 m.39920 sp RS2_ICTPU 85.849 212 29 1 41 252 32 242 1.09E-130 374 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q91130 CHOYP_LOC100371965.3.4 m.28742 sp EPD_NOTCY 24.51 204 131 8 1 196 6 194 1.09E-06 50.8 EPD_NOTCY reviewed Ependymin (EPD) epd Notemigonus crysoleucas (Golden shiner) (Cyprinus crysoleucas) 214 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00811; Q91W96 CHOYP_ANAPC4.1.2 m.9316 sp APC4_MOUSE 37.546 807 448 20 6 790 10 782 1.09E-140 438 APC4_MOUSE reviewed Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4) Anapc4 D5Ertd249e Mus musculus (Mouse) 807 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; protein K11-linked ubiquitination [GO:0070979]; regulation of mitotic metaphase/anaphase transition [GO:0030071] GO:0005634; GO:0005680; GO:0007067; GO:0019903; GO:0030071; GO:0031145; GO:0051301; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12896;PF12894; Q95KV7 CHOYP_THTR.1.1 m.25924 sp NDUAD_BOVIN 44.872 78 37 2 7 84 55 126 1.09E-11 61.2 NDUAD_BOVIN reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (Cell death regulatory protein GRIM-19) (Complex I-B16.6) (CI-B16.6) (Gene associated with retinoic-interferon-induced mortality 19 protein) (GRIM-19) (NADH-ubiquinone oxidoreductase B16.6 subunit) NDUFA13 GRIM19 Bos taurus (Bovine) 144 "apoptotic signaling pathway [GO:0097190]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription, DNA-templated [GO:0045892]" GO:0005654; GO:0005737; GO:0005739; GO:0005746; GO:0005747; GO:0008137; GO:0016021; GO:0030308; GO:0045892; GO:0097190; GO:0097191 0 0 0 PF06212; Q9BDB7 CHOYP_BRAFLDRAFT_91636.7.11 m.49692 sp IF44L_MOUSE 28.188 447 293 9 14 450 7 435 1.09E-42 159 IF44L_MOUSE reviewed Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) 447 immune response [GO:0006955] GO:0005654; GO:0005737; GO:0006955 0 0 0 0 Q9BRZ2 CHOYP_LOC100213744.12.19 m.44426 sp TRI56_HUMAN 26.174 298 167 10 40 314 7 274 1.09E-20 100 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9BXJ4 CHOYP_C1QT3.5.8 m.27295 sp C1QT3_HUMAN 33.553 152 65 5 60 199 115 242 1.09E-10 62.4 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9CXI3 CHOYP_TBH1.1.1 m.27112 sp MOXD1_MOUSE 28.859 298 185 11 41 317 195 486 1.09E-29 122 MOXD1_MOUSE reviewed DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X) Moxd1 Dbhr Mox Mus musculus (Mouse) 613 0 GO:0005507; GO:0005789; GO:0016020; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q9D2Z4 CHOYP_BRAFLDRAFT_221105.2.2 m.18319 sp SENP8_MOUSE 43.541 209 116 2 10 217 4 211 1.09E-56 182 SENP8_MOUSE reviewed Sentrin-specific protease 8 (EC 3.4.22.68) (Deneddylase-1) (NEDD8-specific protease 1) (Sentrin/SUMO-specific protease SENP8) Senp8 Den1 Nedp1 Mus musculus (Mouse) 221 0 GO:0008234; GO:0019784 0 0 0 PF02902; Q9D9B4 CHOYP_CAOG_00801.1.2 m.1579 sp CJ011_MOUSE 50.455 220 108 1 2 221 11 229 1.09E-70 218 CJ011_MOUSE reviewed Leucine-rich repeat-containing protein C10orf11 homolog 0 Mus musculus (Mouse) 229 melanocyte differentiation [GO:0030318] GO:0030318 0 0 0 0 Q9EQ32 CHOYP_LOC100703144.1.1 m.26263 sp BCAP_MOUSE 25.478 314 181 9 1 270 122 426 1.09E-18 92 BCAP_MOUSE reviewed Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) Pik3ap1 Bcap Mus musculus (Mouse) 811 negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] GO:0005737; GO:0005829; GO:0005886; GO:0014068; GO:0016020; GO:0034122; GO:0034123; GO:0034134; GO:0034142; GO:0034154; GO:0034162; GO:0036312; GO:0042802; GO:0050727 0 0 0 PF14545; Q9EQD2 CHOYP_ETHR.1.1 m.25112 sp NPFF2_RAT 26.351 296 190 9 31 308 55 340 1.09E-18 90.1 NPFF2_RAT reviewed Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor) Npffr2 Gpr74 Npff2 Npgpr Rattus norvegicus (Rat) 417 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; regulation of adenylate cyclase activity [GO:0045761]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of MAPK cascade [GO:0043408]; response to peptide [GO:1901652] GO:0005887; GO:0007268; GO:0008188; GO:0015629; GO:0032870; GO:0042277; GO:0043408; GO:0045761; GO:1901652; GO:2000479 0 0 0 PF00001; Q9ESN6 CHOYP_BRAFLDRAFT_88219.3.5 m.47356 sp TRIM2_MOUSE 26.415 212 146 4 267 473 536 742 1.09E-12 73.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAR2 CHOYP_LOC101077846.2.2 m.47534 sp AGRL3_HUMAN 25.463 648 417 20 505 1120 495 1108 1.09E-52 206 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9HCF6 CHOYP_TRPM3.7.7 m.59826 sp TRPM3_HUMAN 23.695 1207 713 35 403 1449 109 1267 1.09E-75 281 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9NZ20 CHOYP_LOC100569429.1.1 m.29546 sp PA2G3_HUMAN 36.054 147 85 1 206 352 142 279 1.09E-25 110 PA2G3_HUMAN reviewed Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3) PLA2G3 Homo sapiens (Human) 509 acrosome assembly [GO:0001675]; cilium morphogenesis [GO:0060271]; lipid catabolic process [GO:0016042]; lipoxygenase pathway [GO:0019372]; mast cell degranulation [GO:0043303]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid metabolic process [GO:0006644]; sperm axoneme assembly [GO:0007288] GO:0001675; GO:0004623; GO:0005576; GO:0005615; GO:0005814; GO:0005886; GO:0006644; GO:0007288; GO:0016042; GO:0019372; GO:0036148; GO:0036151; GO:0036152; GO:0042629; GO:0043303; GO:0046872; GO:0047498; GO:0060271 0 0 0 PF05826; Q9P215 CHOYP_LOC100560153.3.3 m.43974 sp POGK_HUMAN 36.528 386 233 7 2 377 226 609 1.09E-83 270 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9QYK7 CHOYP_RNF11.1.2 m.40383 sp RNF11_MOUSE 63.433 134 42 2 2 128 21 154 1.09E-55 173 RNF11_MOUSE reviewed RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669) Rnf11 N4wbp2 Sid1669 Mus musculus (Mouse) 154 protein autoubiquitination [GO:0051865]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0004842; GO:0005634; GO:0005769; GO:0006511; GO:0008270; GO:0042787; GO:0051865; GO:0055037; GO:0070062 0 0 0 PF13639; Q9R172 CHOYP_ISCW_ISCW008751.1.1 m.43758 sp NOTC3_RAT 29.921 127 65 5 294 402 846 966 1.09E-06 54.7 NOTC3_RAT reviewed Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Notch3 Rattus norvegicus (Rat) 2319 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; Notch signaling pathway [GO:0007219]; regulation of transcription, DNA-templated [GO:0006355]; tissue regeneration [GO:0042246]; transcription, DNA-templated [GO:0006351]" GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0007219; GO:0007275; GO:0016021; GO:0030154; GO:0042246 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; Q9UKK3 CHOYP_CAOG_03714.1.1 m.63840 sp PARP4_HUMAN 39.056 233 121 4 1 224 1074 1294 1.09E-38 145 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9W5U2 CHOYP_ISCW_ISCW016212.2.2 m.46221 sp CHIT3_DROME 38.134 729 389 18 19 703 965 1675 1.09E-152 493 CHIT3_DROME reviewed Probable chitinase 3 (EC 3.2.1.14) (Probable chitinase 1) Cht3 Cht1 CG18140 Drosophila melanogaster (Fruit fly) 2286 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0006032; GO:0008061 0 0 0 PF01607;PF00704; Q9Y3B9 CHOYP_LOC100549868.1.1 m.30652 sp RRP15_HUMAN 42.797 236 112 6 54 270 36 267 1.09E-41 147 RRP15_HUMAN reviewed RRP15-like protein (Ribosomal RNA-processing protein 15) RRP15 KIAA0507 CGI-115 Homo sapiens (Human) 282 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0005634; GO:0005730; GO:0005739; GO:0030687 0 0 0 PF07890; Q9Y5K3 CHOYP_LOC100121773.1.1 m.50732 sp PCY1B_HUMAN 54.704 287 110 4 40 310 39 321 1.09E-114 340 PCY1B_HUMAN reviewed Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) 369 ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid biosynthetic process [GO:0008654]; spermatogenesis [GO:0007283] GO:0001541; GO:0004105; GO:0005737; GO:0005789; GO:0006656; GO:0007283; GO:0008654 PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. {ECO:0000250|UniProtKB:P19836}. 0 0 PF01467; A0A0R4IBK5 CHOYP_RN213.11.13 m.59720 sp R213A_DANRE 23.586 1662 1083 57 488 2034 175 1764 1.10E-86 322 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0JPH4 CHOYP_SCAP.1.1 m.25558 sp SCAP_XENLA 39.45 109 55 2 1 109 4 101 1.10E-18 83.2 SCAP_XENLA reviewed Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) scap Xenopus laevis (African clawed frog) 1311 cholesterol metabolic process [GO:0008203]; SREBP signaling pathway [GO:0032933] GO:0000139; GO:0005789; GO:0008203; GO:0012507; GO:0015485; GO:0016021; GO:0032933 0 0 0 PF12349;PF00400; A1ZA47 CHOYP_SMP_045300.1.1 m.927 sp ZASP_DROME 46.988 83 42 2 4 85 7 88 1.10E-14 71.6 ZASP_DROME reviewed PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) 2194 muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952] GO:0001725; GO:0001952; GO:0003779; GO:0005915; GO:0005925; GO:0005927; GO:0008270; GO:0015629; GO:0016323; GO:0030018; GO:0030239; GO:0031252; GO:0045177; GO:0045178; GO:0051371; GO:0061061 0 0 0 PF15936;PF00412;PF00595; A4IF63 CHOYP_BRAFLDRAFT_205687.1.2 m.29290 sp TRIM2_BOVIN 24.194 248 164 7 215 457 515 743 1.10E-09 64.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IGL7 CHOYP_LOC101159719.1.1 m.21443 sp PXDN_XENTR 25.773 291 186 9 211 490 229 500 1.10E-18 93.6 PXDN_XENTR reviewed Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1457 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF03098;PF07679;PF13855;PF00093; B0JZG0 CHOYP_LOC100376056.1.2 m.12781 sp S23A2_XENTR 42.726 543 298 4 41 576 87 623 1.10E-155 464 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; B3EWY9 CHOYP_contig_006213 m.7050 sp MLP_ACRMI 29.643 1093 598 37 310 1339 379 1363 1.10E-112 400 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B4PEU8 CHOYP_RS9.7.13 m.40774 sp RS9_DROYA 86.792 159 21 0 3 161 4 162 1.10E-95 279 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; D2GXS7 CHOYP_BRAFLDRAFT_87328.2.2 m.64685 sp TRIM2_AILME 34.524 84 51 3 24 106 627 707 1.10E-06 48.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_LOC100369186.1.9 m.3569 sp TRIM2_AILME 28.571 119 82 2 349 465 627 744 1.10E-06 54.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_LOC100373888.2.9 m.18306 sp TRIM2_AILME 25.097 259 140 8 354 562 490 744 1.10E-11 71.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZQG6 CHOYP_BRAFLDRAFT_85511.6.23 m.32485 sp TRIM2_RAT 26.471 136 90 4 25 151 560 694 1.10E-07 53.5 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O08746 CHOYP_BRAFLDRAFT_92024.1.1 m.49813 sp MATN2_MOUSE 36.321 212 126 5 170 376 47 254 1.10E-28 126 MATN2_MOUSE reviewed Matrilin-2 Matn2 Mus musculus (Mouse) 956 axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; response to axon injury [GO:0048678] GO:0001764; GO:0005509; GO:0005578; GO:0005604; GO:0007411; GO:0008347; GO:0031104; GO:0031175; GO:0048678 0 0 0 PF07645;PF10393;PF00092; O75179 CHOYP_LOC581927.2.27 m.14270 sp ANR17_HUMAN 35.622 466 277 16 112 558 241 702 1.10E-54 207 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75179 CHOYP_LOC753709.17.44 m.32911 sp ANR17_HUMAN 30.813 529 331 17 260 771 208 718 1.10E-46 184 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_BRAFLDRAFT_87320.2.2 m.46255 sp TRIM3_HUMAN 27.481 131 90 2 32 158 614 743 1.10E-07 54.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O95260 CHOYP_ATE1.1.3 m.6900 sp ATE1_HUMAN 40.432 324 144 7 24 301 8 328 1.10E-68 226 ATE1_HUMAN reviewed Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Homo sapiens (Human) 518 protein arginylation [GO:0016598] GO:0004057; GO:0005634; GO:0005737; GO:0016598 0 0 0 PF04377;PF04376; O95271 CHOYP_LOC753709.40.44 m.64119 sp TNKS1_HUMAN 38.211 123 71 4 6 124 679 800 1.10E-12 67 TNKS1_HUMAN reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) 1327 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000242; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007052; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0031965; GO:0032210; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; P00548 CHOYP_KPYK.2.4 m.19753 sp KPYM_CHICK 62.5 160 56 1 39 194 8 167 1.10E-64 210 KPYM_CHICK reviewed Pyruvate kinase PKM (EC 2.7.1.40) PKM Gallus gallus (Chicken) 530 glycolytic process [GO:0006096] GO:0000287; GO:0004743; GO:0005524; GO:0005829; GO:0006096; GO:0016301; GO:0030955 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. 0 0 PF00224;PF02887; P13804 CHOYP_LOC100372693.1.1 m.16279 sp ETFA_HUMAN 66.667 336 108 3 43 377 1 333 1.10E-155 444 ETFA_HUMAN reviewed "Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF)" ETFA Homo sapiens (Human) 333 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; lipid homeostasis [GO:0055088]; respiratory electron transport chain [GO:0022904] GO:0000062; GO:0003995; GO:0005739; GO:0005759; GO:0009055; GO:0016491; GO:0022904; GO:0033539; GO:0050660; GO:0052890; GO:0055088; GO:0070062 0 0 0 PF01012;PF00766; P16157 CHOYP_TVAG_020440.15.21 m.42720 sp ANK1_HUMAN 38.875 409 250 0 3 411 255 663 1.10E-71 248 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P27046 CHOYP_NEMVEDRAFT_V1G166900.1.1 m.26418 sp MA2A1_MOUSE 30.411 365 215 9 34 381 803 1145 1.10E-44 168 MA2A1_MOUSE reviewed "Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" Man2a1 Mana2 Mus musculus (Mouse) 1150 in utero embryonic development [GO:0001701]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; mannose metabolic process [GO:0006013]; mitochondrion organization [GO:0007005]; N-glycan processing [GO:0006491]; positive regulation of neurogenesis [GO:0050769]; protein deglycosylation [GO:0006517]; respiratory gaseous exchange [GO:0007585]; retina morphogenesis in camera-type eye [GO:0060042]; vacuole organization [GO:0007033] GO:0000139; GO:0001701; GO:0001889; GO:0004559; GO:0004572; GO:0005615; GO:0005794; GO:0005801; GO:0006013; GO:0006491; GO:0006517; GO:0007005; GO:0007033; GO:0007585; GO:0008270; GO:0015923; GO:0016020; GO:0016021; GO:0016787; GO:0016799; GO:0030246; GO:0048286; GO:0050769; GO:0060042; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09261;PF01074;PF07748; P28827 CHOYP_PTPRM.5.15 m.36879 sp PTPRM_HUMAN 32.945 601 368 14 531 1114 867 1449 1.10E-80 293 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P32240 CHOYP_PE2R4.1.5 m.23483 sp PE2R4_MOUSE 27.99 393 222 10 2 341 33 417 1.10E-26 113 PE2R4_MOUSE reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Ptgerep4 Mus musculus (Mouse) 513 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005887; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0030278; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P41105 CHOYP_contig_049638 m.58934 sp RL28_MOUSE 59.055 127 52 0 25 151 2 128 1.10E-51 164 RL28_MOUSE reviewed 60S ribosomal protein L28 Rpl28 Mus musculus (Mouse) 137 positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; translation [GO:0006412] GO:0003735; GO:0005737; GO:0006412; GO:0016020; GO:0022625; GO:0030425; GO:0036464; GO:0044297; GO:0044822; GO:0070062; GO:1903146; GO:1903955 0 0 0 PF01778; P46197 CHOYP_LOC580109.3.3 m.29351 sp ANPRB_BOVIN 57.438 242 95 2 382 623 811 1044 1.10E-78 273 ANPRB_BOVIN reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 Bos taurus (Bovine) 1047 cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007168; GO:0008074; GO:0016941; GO:0035556; GO:0042802 0 0 0 PF01094;PF00211;PF07714; P49165 CHOYP_RL4B.1.1 m.62935 sp RL4_URECA 65.969 191 57 3 1 188 195 380 1.10E-78 242 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; P54353 CHOYP_EF1A.3.4 m.63416 sp DOD_DROME 62.733 161 49 1 2 151 4 164 1.10E-65 200 DOD_DROME reviewed Putative peptidyl-prolyl cis-trans isomerase dodo (PPIase dodo) (EC 5.2.1.8) (Rotamase dodo) dod CG17051 Drosophila melanogaster (Fruit fly) 166 epidermal growth factor receptor signaling pathway [GO:0007173] GO:0003755; GO:0005634; GO:0007173 0 0 0 PF00639;PF00397; P61857 CHOYP_LOC373275.4.7 m.47550 sp TBB2_DROME 76.471 51 10 1 93 143 151 199 1.10E-15 75.9 TBB2_DROME reviewed Tubulin beta-2 chain (Beta-2-tubulin) betaTub85D TubB85D CG9359 Drosophila melanogaster (Fruit fly) 446 microtubule-based process [GO:0007017]; salivary gland morphogenesis [GO:0007435] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0007435 0 0 0 PF00091;PF03953; P86854 CHOYP_SLB.1.1 m.38254 sp PLCL_MYTGA 21.965 173 104 4 66 236 13 156 1.10E-08 55.8 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q04073 CHOYP_P3A2.1.3 m.11560 sp P3A2_STRPU 55.804 448 138 13 35 436 2 435 1.10E-146 429 P3A2_STRPU reviewed DNA-binding protein P3A2 0 Strongylocentrotus purpuratus (Purple sea urchin) 459 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF10492;PF10491; Q05695 CHOYP_AGAP_AGAP000720.1.1 m.45251 sp L1CAM_RAT 24.173 393 254 14 61 432 52 421 1.10E-22 106 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q12955 CHOYP_LOC100640442.10.10 m.64691 sp ANK3_HUMAN 27.995 793 489 25 127 862 48 815 1.10E-49 195 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q15013 CHOYP_LOC100378297.1.1 m.19093 sp MD2BP_HUMAN 29.032 186 124 3 35 217 70 250 1.10E-18 88.2 MD2BP_HUMAN reviewed MAD2L1-binding protein (Caught by MAD2 protein) MAD2L1BP CMT2 KIAA0110 Homo sapiens (Human) 274 mitotic cell cycle checkpoint [GO:0007093]; regulation of exit from mitosis [GO:0007096] GO:0005634; GO:0005737; GO:0005819; GO:0007093; GO:0007096 0 0 0 PF06581; Q2PC93 CHOYP_SSPO.14.14 m.60297 sp SSPO_CHICK 29.6 250 151 8 854 1084 2572 2815 1.10E-20 103 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q2TBX6 CHOYP_PSB1.2.2 m.63827 sp PSB1_BOVIN 66.81 232 77 0 35 266 10 241 1.10E-111 324 PSB1_BOVIN reviewed Proteasome subunit beta type-1 (EC 3.4.25.1) PSMB1 Bos taurus (Bovine) 241 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0051603 0 0 0 PF00227; Q2V2M9 CHOYP_LOC100869084.1.1 m.54798 sp FHOD3_HUMAN 52.206 544 229 12 1909 2433 864 1395 1.10E-158 535 FHOD3_HUMAN reviewed FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) FHOD3 FHOS2 KIAA1695 Homo sapiens (Human) 1422 actin filament network formation [GO:0051639]; cardiac myofibril assembly [GO:0055003]; negative regulation of actin filament polymerization [GO:0030837]; sarcomere organization [GO:0045214] GO:0005856; GO:0030018; GO:0030837; GO:0045214; GO:0051639; GO:0055003 0 0 0 PF02181; Q4R8M9 CHOYP_BRAFLDRAFT_124130.2.3 m.30247 sp GTSF1_MACFA 55.072 69 29 1 8 74 10 78 1.10E-21 94.4 GTSF1_MACFA reviewed Gametocyte-specific factor 1 (Protein FAM112B) GTSF1 FAM112B QtsA-12026 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 167 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0005737; GO:0007283; GO:0030154; GO:0046872 0 0 0 PF05253; Q504A5 CHOYP_LOC100366428.1.1 m.3740 sp TPMT_DANRE 50.917 218 106 1 14 230 14 231 1.10E-75 231 TPMT_DANRE reviewed Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) 232 nucleobase-containing compound metabolic process [GO:0006139] GO:0005737; GO:0006139; GO:0008119 0 0 0 PF05724; Q54271 CHOYP_NEMVEDRAFT_V1G168076.1.2 m.48223 sp PPD_STRHY 30 300 185 6 1 286 75 363 1.10E-40 149 PPD_STRHY reviewed Phosphonopyruvate decarboxylase (EC 4.1.1.82) bcpC Streptomyces hygroscopicus 401 antibiotic biosynthetic process [GO:0017000]; organic phosphonate biosynthetic process [GO:0032923] GO:0017000; GO:0030976; GO:0032923; GO:0033980 PATHWAY: Secondary metabolite biosynthesis; bialaphos biosynthesis. 0 0 PF02775;PF02776; Q567I9 CHOYP_LOC593741.1.1 m.11514 sp CB5D1_DANRE 71.028 214 61 1 21 234 1 213 1.10E-107 311 CB5D1_DANRE reviewed Cytochrome b5 domain-containing protein 1 cyb5d1 zgc:112008 Danio rerio (Zebrafish) (Brachydanio rerio) 214 0 GO:0046872 0 0 0 PF00173; Q5HZT0 CHOYP_BRAFLDRAFT_88205.1.1 m.8100 sp DXO_XENLA 42.34 359 192 5 38 389 49 399 1.10E-100 307 DXO_XENLA reviewed Decapping and exoribonuclease protein (DXO) (EC 3.1.13.-) (EC 3.6.1.-) (Dom-3 homolog Z) dxo dom3z Xenopus laevis (African clawed frog) 401 metabolic process [GO:0008152]; mRNA catabolic process [GO:0006402]; nuclear mRNA surveillance [GO:0071028]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; RNA destabilization [GO:0050779] GO:0000166; GO:0000287; GO:0003729; GO:0005634; GO:0006402; GO:0008152; GO:0008409; GO:0034353; GO:0050779; GO:0071028; GO:0090305 0 0 0 PF08652; Q5M9G3 CHOYP_LOC100696604.1.1 m.40638 sp CAPR1_RAT 32.362 618 323 24 4 546 52 649 1.10E-62 223 CAPR1_RAT reviewed Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105) Caprin1 Gpiap1 Rng105 Rattus norvegicus (Rat) 707 negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003] GO:0000932; GO:0003723; GO:0005829; GO:0010494; GO:0017148; GO:0030425; GO:0050775; GO:0061003 0 0 0 PF12287; Q5ND28 CHOYP_CED1.8.29 m.29029 sp SREC_MOUSE 31.228 285 147 12 26 309 153 389 1.10E-19 95.1 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5R5L7 CHOYP_LOC100176335.4.7 m.40192 sp ARRD3_PONAB 33.058 363 221 10 1 353 3 353 1.10E-53 186 ARRD3_PONAB reviewed Arrestin domain-containing protein 3 ARRDC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 414 0 GO:0005764; GO:0005769; GO:0005886 0 0 0 PF02752;PF00339; Q5RBM1 CHOYP_LOC100376827.1.1 m.60291 sp RPN2_PONAB 38.951 629 364 10 8 625 9 628 1.10E-138 421 RPN2_PONAB reviewed Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (EC 2.4.99.18) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) RPN2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 631 protein N-linked glycosylation [GO:0006487] GO:0006487; GO:0008250; GO:0016021; GO:0016757 PATHWAY: Protein modification; protein glycosylation. 0 0 PF05817; Q60675 CHOYP_LOC100649561.1.1 m.19233 sp LAMA2_MOUSE 29.129 999 597 30 1 916 1229 2199 1.10E-101 352 LAMA2_MOUSE reviewed Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) Lama2 Mus musculus (Mouse) 3118 "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; myelination in peripheral nervous system [GO:0022011]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]" GO:0005576; GO:0005604; GO:0005605; GO:0007155; GO:0007411; GO:0022011; GO:0030155; GO:0030198; GO:0030334; GO:0032224; GO:0042383; GO:0043197; GO:0045995; GO:0070062 0 0 0 PF00052;PF00053;PF00054;PF02210;PF06008;PF06009;PF00055; Q61733 CHOYP_VIGLN.2.2 m.61191 sp RT31_MOUSE 54.737 95 42 1 1356 1450 285 378 1.10E-29 126 RT31_MOUSE reviewed "28S ribosomal protein S31, mitochondrial (MRP-S31) (S31mt) (Imogen 38)" Mrps31 Imogn38 Mus musculus (Mouse) 384 0 GO:0003735; GO:0005730; GO:0005739; GO:0005763; GO:0019904; GO:0044822 0 0 0 PF15433; Q64424 CHOYP_LIPR2.2.2 m.49351 sp LIPR2_MYOCO 40.176 341 179 7 29 346 19 357 1.10E-67 223 LIPR2_MYOCO reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) PNLIPRP2 Myocastor coypus (Coypu) (Nutria) 470 galactolipid catabolic process [GO:0019376]; phospholipid catabolic process [GO:0009395] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0009395; GO:0019376; GO:0047372; GO:0047714 0 0 0 PF00151;PF01477; Q66S03 CHOYP_LOC100372598.2.2 m.29982 sp LECG_THANI 34.375 160 93 6 1 152 4 159 1.10E-22 91.3 LECG_THANI reviewed Galactose-specific lectin nattectin (CTL) 0 Thalassophryne nattereri (Niquim) 159 inflammatory response [GO:0006954] GO:0005576; GO:0006954; GO:0030246; GO:0046872 0 0 0 PF00059; Q6AXN4 CHOYP_NDC1.1.1 m.13280 sp NDC1_RAT 32.898 383 232 9 27 388 24 402 1.10E-61 218 NDC1_RAT reviewed Nucleoporin NDC1 (Transmembrane protein 48) Ndc1 Tmem48 Rattus norvegicus (Rat) 673 mRNA transport [GO:0051028]; nuclear pore organization [GO:0006999]; protein transport [GO:0015031] GO:0006999; GO:0015031; GO:0016021; GO:0017056; GO:0031965; GO:0051028; GO:0070762 0 0 0 PF09531; Q6DC17 CHOYP_LOC100733272.1.1 m.7162 sp MZT2_DANRE 50.704 71 34 1 11 80 20 90 1.10E-17 76.3 MZT2_DANRE reviewed Mitotic-spindle organizing protein 2 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2) mzt2 fam128 mozart2 zgc:101080 Danio rerio (Zebrafish) (Brachydanio rerio) 153 0 GO:0005813; GO:0005819; GO:0008274 0 0 0 PF12926; Q6DC17 CHOYP_OSBP1.1.1 m.12789 sp MZT2_DANRE 50.704 71 34 1 11 80 20 90 1.10E-17 76.3 MZT2_DANRE reviewed Mitotic-spindle organizing protein 2 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2) mzt2 fam128 mozart2 zgc:101080 Danio rerio (Zebrafish) (Brachydanio rerio) 153 0 GO:0005813; GO:0005819; GO:0008274 0 0 0 PF12926; Q6DF30 CHOYP_DPSE_GA17556.1.1 m.110 sp DHDH_XENTR 36.31 168 107 0 3 170 160 327 1.10E-29 114 DHDH_XENTR reviewed "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 330 D-xylose catabolic process [GO:0042843] GO:0042843; GO:0047115; GO:0047837 0 0 0 PF01408; Q6DHC3 CHOYP_BRAFLDRAFT_124058.1.1 m.7571 sp S2540_DANRE 54.277 339 145 8 8 344 13 343 1.10E-123 362 S2540_DANRE reviewed Solute carrier family 25 member 40 slc25a40 zgc:92520 Danio rerio (Zebrafish) (Brachydanio rerio) 353 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q6DIB5 CHOYP_PEAR1.13.16 m.55489 sp MEG10_MOUSE 37.725 334 171 17 130 447 259 571 1.10E-39 158 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6GLT8 CHOYP_FAHD2.1.1 m.12574 sp FAHD2_XENLA 53.082 292 134 2 3 292 29 319 1.10E-113 333 FAHD2_XENLA reviewed Fumarylacetoacetate hydrolase domain-containing protein 2 (EC 3.-.-.-) fahd2 fahd2a Xenopus laevis (African clawed frog) 319 metabolic process [GO:0008152] GO:0008152; GO:0016787; GO:0046872 0 0 0 PF01557; Q6GQ48 CHOYP_LIAS.1.1 m.21693 sp LIAS_XENLA 68.513 343 101 3 51 386 29 371 1.10E-172 489 LIAS_XENLA reviewed "Lipoyl synthase, mitochondrial (EC 2.8.1.8) (Lipoate synthase) (LS) (Lip-syn) (Lipoic acid synthase)" lias Xenopus laevis (African clawed frog) 372 protein lipoylation [GO:0009249] GO:0005739; GO:0009249; GO:0016992; GO:0046872; GO:0051539 PATHWAY: Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03123}. 0 0 PF16881;PF04055; Q6GYQ0 CHOYP_RGPA2.1.1 m.25497 sp RGPA1_HUMAN 36.069 865 428 21 7 776 1 835 1.10E-151 494 RGPA1_HUMAN reviewed Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) RALGAPA1 GARNL1 KIAA0884 TULIP1 Homo sapiens (Human) 2036 "activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005096; GO:0005634; GO:0005737; GO:0006355; GO:0046982; GO:0051056; GO:0090630 0 0 0 PF02145; Q6NS60 CHOYP_FBX41.2.2 m.25359 sp FBX41_MOUSE 43.363 226 126 1 1 226 646 869 1.10E-57 198 FBX41_MOUSE reviewed F-box only protein 41 Fbxo41 D6Ertd538e Kiaa1940 Mus musculus (Mouse) 873 0 0 0 0 0 PF12937; Q7QH62 CHOYP_MED4.1.1 m.12006 sp MED4_ANOGA 49.794 243 111 6 4 238 6 245 1.10E-69 218 MED4_ANOGA reviewed Mediator of RNA polymerase II transcription subunit 4 (Mediator complex subunit 4) MED4 AGAP004063 Anopheles gambiae (African malaria mosquito) 263 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0006357; GO:0016592; GO:0070847 0 0 0 PF10018; Q8BYI9 CHOYP_NEO1.1.3 m.3409 sp TENR_MOUSE 28.507 221 130 10 38 248 474 676 1.10E-06 53.5 TENR_MOUSE reviewed Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Mus musculus (Mouse) 1358 "associative learning [GO:0008306]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; modulation of synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007158; GO:0008306; GO:0009986; GO:0010977; GO:0022029; GO:0022408; GO:0030198; GO:0030517; GO:0035641; GO:0045121; GO:0046625; GO:0048692; GO:0050804; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF00147;PF00041; Q8ITC3 CHOYP_RS19.4.12 m.17060 sp RS19_ARGIR 74.483 145 36 1 31 175 1 144 1.10E-78 233 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8IWV2 CHOYP_DGRI_GH10697.1.1 m.44819 sp CNTN4_HUMAN 35.165 91 51 3 1 91 421 503 1.10E-07 53.9 CNTN4_HUMAN reviewed Contactin-4 (Brain-derived immunoglobulin superfamily protein 2) (BIG-2) CNTN4 Homo sapiens (Human) 1026 axonal fasciculation [GO:0007413]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; brain development [GO:0007420]; negative regulation of neuron differentiation [GO:0045665]; nervous system development [GO:0007399]; neuron cell-cell adhesion [GO:0007158]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167] GO:0005576; GO:0005886; GO:0007158; GO:0007399; GO:0007409; GO:0007411; GO:0007413; GO:0007420; GO:0030424; GO:0031175; GO:0031225; GO:0045665; GO:0048167 0 0 0 PF00041;PF07679; Q8K0U4 CHOYP_HSPA12A.17.27 m.48334 sp HS12A_MOUSE 23.355 471 287 18 3 404 57 522 1.10E-19 96.7 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K0U4 CHOYP_ISCW_ISCW012626.1.4 m.21354 sp HS12A_MOUSE 24.219 384 261 10 11 376 303 674 1.10E-29 124 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N3J2 CHOYP_METTL4.1.2 m.12538 sp METL4_HUMAN 39.623 265 106 4 19 282 236 447 1.10E-50 176 METL4_HUMAN reviewed Methyltransferase-like protein 4 (EC 2.1.1.-) METTL4 Homo sapiens (Human) 472 0 GO:0003676; GO:0005634; GO:0009007 0 0 0 PF05063; Q8N7X2 CHOYP_LOC100378134.1.1 m.11550 sp CI173_HUMAN 37.975 79 47 2 70 147 94 171 1.10E-07 55.5 CI173_HUMAN reviewed Uncharacterized protein C9orf173 C9orf173 Homo sapiens (Human) 389 0 0 0 0 0 0 Q8STF0 CHOYP_CALM.1.50 m.727 sp CALM_STRIE 94.483 145 8 0 8 152 12 156 1.10E-95 276 CALM_STRIE reviewed Calmodulin (CaM) 0 Strongylocentrotus intermedius (Sea urchin) 156 0 GO:0005509 0 0 0 PF13499; Q8UWD8 CHOYP_GDF8.3.3 m.44624 sp GDF8_COLLI 33.421 380 209 16 62 426 25 375 1.10E-55 191 GDF8_COLLI reviewed Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Columba livia (Rock dove) 375 growth [GO:0040007]; muscle cell proliferation [GO:0033002]; negative regulation of myoblast proliferation [GO:2000818]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723] GO:0005615; GO:0033002; GO:0040007; GO:1902723; GO:1902725; GO:2000818 0 0 0 PF00019;PF00688; Q90Z10 CHOYP_RL13.4.4 m.53597 sp RL13_DANRE 67.773 211 68 0 1 211 1 211 1.10E-95 280 RL13_DANRE reviewed 60S ribosomal protein L13 rpl13 Danio rerio (Zebrafish) (Brachydanio rerio) 211 regulation of cell cycle [GO:0051726]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0051726 0 0 0 PF01294; Q96MB7 CHOYP_LOC101171725.3.3 m.62457 sp HARB1_HUMAN 38.462 286 168 4 24 301 27 312 1.10E-62 206 HARB1_HUMAN reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0005813; GO:0046872 0 0 0 PF13359; Q96QF0 CHOYP_BRAFLDRAFT_199346.1.3 m.11369 sp RAB3I_HUMAN 47.239 326 146 4 247 560 160 471 1.10E-90 290 RAB3I_HUMAN reviewed Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein) RAB3IP RABIN8 Homo sapiens (Human) 476 cilium assembly [GO:0042384]; Golgi to plasma membrane transport [GO:0006893]; protein localization to organelle [GO:0033365]; protein targeting to membrane [GO:0006612] GO:0005634; GO:0005813; GO:0005829; GO:0005856; GO:0006612; GO:0006893; GO:0017112; GO:0030027; GO:0033365; GO:0036064; GO:0042384 0 0 0 PF06428; Q99NH0 CHOYP_LOC753709.22.44 m.41543 sp ANR17_MOUSE 31.618 408 213 16 437 791 241 635 1.10E-32 140 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9HC62 CHOYP_LOC100892304.1.1 m.35377 sp SENP2_HUMAN 27.564 156 106 4 170 318 397 552 1.10E-10 67 SENP2_HUMAN reviewed Sentrin-specific protease 2 (EC 3.4.22.68) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 Homo sapiens (Human) 589 "dorsal/ventral axis specification [GO:0009950]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; labyrinthine layer development [GO:0060711]; mRNA transport [GO:0051028]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of DNA endoreduplication [GO:0032875]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of Wnt signaling pathway [GO:0030111]; spongiotrophoblast layer development [GO:0060712]; trophoblast giant cell differentiation [GO:0060707]; Wnt signaling pathway [GO:0016055]" GO:0001934; GO:0004175; GO:0005643; GO:0005654; GO:0007507; GO:0009950; GO:0015031; GO:0016055; GO:0016605; GO:0016925; GO:0016926; GO:0016929; GO:0030111; GO:0031397; GO:0031398; GO:0031410; GO:0031648; GO:0031965; GO:0032091; GO:0032875; GO:0035562; GO:0043518; GO:0045444; GO:0045944; GO:0051028; GO:0060707; GO:0060711; GO:0060712; GO:0070139; GO:2000045 0 0 0 PF02902; Q9R0M3 CHOYP_LOC593709.1.2 m.22712 sp SRPX_MOUSE 28.421 190 129 6 93 279 120 305 1.10E-13 75.5 SRPX_MOUSE reviewed Sushi-repeat-containing protein SRPX (DRS protein) Srpx Mus musculus (Mouse) 464 autophagy [GO:0006914]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976] GO:0001845; GO:0005776; GO:0005783; GO:0006914; GO:0034976; GO:0060244; GO:2001241 0 0 0 PF13778;PF02494;PF00084; Q9R0W9 CHOYP_ACHA6.2.4 m.12690 sp ACHA6_MOUSE 28.406 345 187 8 2 293 103 440 1.10E-44 161 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9UM73 CHOYP_BRAFLDRAFT_216804.1.1 m.39099 sp ALK_HUMAN 55.357 280 121 3 627 905 1108 1384 1.10E-97 341 ALK_HUMAN reviewed ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) ALK Homo sapiens (Human) 1620 activation of MAPK activity [GO:0000187]; cell proliferation [GO:0008283]; neuron development [GO:0048666]; phosphorylation [GO:0016310]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000187; GO:0004704; GO:0004713; GO:0004714; GO:0005524; GO:0005622; GO:0005887; GO:0007165; GO:0007169; GO:0008283; GO:0016310; GO:0042802; GO:0042981; GO:0043234; GO:0046777; GO:0048666; GO:0051092; GO:0070062 0 0 cd06263; PF00629;PF07714; A2VDN6 CHOYP_BRAFLDRAFT_89362.1.1 m.49683 sp SF3A1_BOVIN 68.376 117 37 0 961 1077 677 793 1.11E-42 171 SF3A1_BOVIN reviewed Splicing factor 3A subunit 1 SF3A1 Bos taurus (Bovine) 793 "mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000381; GO:0000389; GO:0000398; GO:0003723; GO:0005654; GO:0005684; GO:0005686; GO:0044822; GO:0071004; GO:0071013 0 0 0 PF12230;PF01805;PF00240; A5YM72 CHOYP_CARNS1.4.6 m.40245 sp CRNS1_HUMAN 32.52 246 156 5 3 238 100 345 1.11E-21 97.1 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A6QLU6 CHOYP_CELR2.1.8 m.241 sp AGRD1_BOVIN 52.459 61 29 0 12 72 788 848 1.11E-16 79.3 AGRD1_BOVIN reviewed Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) ADGRD1 GPR133 Bos taurus (Bovine) 902 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579] GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0010579; GO:0016021 0 0 0 PF00002;PF01825; D2GXS7 CHOYP_BRAFLDRAFT_87307.3.5 m.52716 sp TRIM2_AILME 23.776 143 106 2 105 245 602 743 1.11E-06 55.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E1BJS7 CHOYP_LOC100369186.8.9 m.53355 sp LIN41_BOVIN 24.051 158 101 6 21 166 278 428 1.11E-07 57.8 LIN41_BOVIN reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Bos taurus (Bovine) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; F1M3L7 CHOYP_EPS8.1.2 m.43833 sp EPS8_RAT 37.143 140 78 5 21 155 688 822 1.11E-10 62.8 EPS8_RAT reviewed Epidermal growth factor receptor kinase substrate 8 Eps8 Rattus norvegicus (Rat) 822 actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360] GO:0003779; GO:0005903; GO:0005938; GO:0008344; GO:0008360; GO:0010458; GO:0014069; GO:0016601; GO:0017146; GO:0030054; GO:0030426; GO:0030832; GO:0031532; GO:0032420; GO:0032587; GO:0035591; GO:0036336; GO:0048149; GO:0048365; GO:0051016; GO:0051017; GO:0051764; GO:0070062; GO:0070358 0 0 0 PF08416;PF00018; O14639 CHOYP_LOC100165685.1.1 m.13583 sp ABLM1_HUMAN 26.87 361 163 13 206 558 511 778 1.11E-20 99.8 ABLM1_HUMAN reviewed Actin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin) ABLIM1 ABLIM KIAA0059 LIMAB1 Homo sapiens (Human) 778 cilium assembly [GO:0042384]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; organ morphogenesis [GO:0009887]; visual perception [GO:0007601] GO:0001725; GO:0003779; GO:0005737; GO:0007010; GO:0007601; GO:0008270; GO:0009887; GO:0015629; GO:0030027; GO:0030032; GO:0042384 0 0 0 PF16182;PF00412;PF02209; O15439 CHOYP_MRP4.2.3 m.12625 sp MRP4_HUMAN 40 625 324 6 32 648 694 1275 1.11E-144 457 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O15990 CHOYP_KARG.10.11 m.50640 sp KARG_LIOJA 77.32 194 44 0 2 195 155 348 1.11E-110 323 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O55230 CHOYP_RA51D.1.1 m.18695 sp RA51D_MOUSE 40.323 310 176 3 1 301 10 319 1.11E-69 222 RA51D_MOUSE reviewed DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) Rad51d R51h3 Rad51l3 Mus musculus (Mouse) 329 cellular response to DNA damage stimulus [GO:0006974]; chromosome organization [GO:0051276]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic DNA recombinase assembly [GO:0000707]; mitotic recombination [GO:0006312]; nucleotide-excision repair [GO:0006289]; reciprocal meiotic recombination [GO:0007131]; regulation of cell cycle [GO:0051726]; response to ionizing radiation [GO:0010212]; strand invasion [GO:0042148]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722] GO:0000150; GO:0000400; GO:0000707; GO:0000722; GO:0000723; GO:0000724; GO:0000781; GO:0000784; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005813; GO:0006289; GO:0006312; GO:0006974; GO:0007131; GO:0008094; GO:0010212; GO:0033063; GO:0036297; GO:0042148; GO:0043015; GO:0051276; GO:0051726 0 0 0 PF08423; O70277 CHOYP_BRAFLDRAFT_205965.41.43 m.64654 sp TRIM3_RAT 25.954 131 88 4 60 182 614 743 1.11E-06 52 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75311 CHOYP_LOC100533289.5.6 m.58733 sp GLRA3_HUMAN 42.548 416 189 6 38 405 38 451 1.11E-113 343 GLRA3_HUMAN reviewed Glycine receptor subunit alpha-3 GLRA3 Homo sapiens (Human) 464 "chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; protein homooligomerization [GO:0051260]; response to amino acid [GO:0043200]; synaptic transmission, glycinergic [GO:0060012]" GO:0005886; GO:0005887; GO:0007218; GO:0016594; GO:0016934; GO:0016935; GO:0022852; GO:0030054; GO:0030425; GO:0034220; GO:0043200; GO:0043204; GO:0045211; GO:0046872; GO:0051260; GO:0060012; GO:1902476 0 0 0 PF02931;PF02932; O75382 CHOYP_BRAFLDRAFT_71597.1.3 m.32695 sp TRIM3_HUMAN 21.978 273 179 10 301 555 488 744 1.11E-08 61.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88281 CHOYP_MEGF6.40.59 m.46665 sp MEGF6_RAT 38.75 400 208 20 202 600 842 1205 1.11E-53 203 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P05099 CHOYP_LOC100175867.1.1 m.48982 sp MATN1_CHICK 28.341 434 257 12 24 423 36 449 1.11E-42 159 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P07882 CHOYP_LOC100771549.1.1 m.35040 sp CEL_RAT 30.372 349 191 15 1 334 215 526 1.11E-24 109 CEL_RAT reviewed Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) Cel Rattus norvegicus (Rat) 612 lipid catabolic process [GO:0016042]; modulation of synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; synapse assembly [GO:0007416] GO:0004622; GO:0004771; GO:0004806; GO:0004872; GO:0005615; GO:0005737; GO:0005791; GO:0005794; GO:0005829; GO:0005887; GO:0007158; GO:0007416; GO:0009986; GO:0016042; GO:0032403; GO:0042043; GO:0042588; GO:0043208; GO:0043231; GO:0043234; GO:0045121; GO:0045202; GO:0050253; GO:0050804; GO:0052689 0 0 0 PF00135; P09481 CHOYP_ACHA3.2.2 m.62137 sp ACHA3_CHICK 28.354 328 225 5 25 346 26 349 1.11E-37 145 ACHA3_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) 496 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; P0C0W8 CHOYP_LOC100215960.1.1 m.44033 sp GP139_RAT 30.597 134 70 4 150 273 177 297 1.11E-08 58.9 GP139_RAT reviewed Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) Gpr139 Gprg1 Rattus norvegicus (Rat) 345 phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200] GO:0005886; GO:0007200; GO:0008188; GO:0016021 0 0 0 PF00001; P13590 CHOYP_PHUM_PHUM080420.1.2 m.46924 sp NCAM1_CHICK 25.598 418 255 22 190 585 9 392 1.11E-06 57 NCAM1_CHICK reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) 1091 cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167] GO:0005886; GO:0007155; GO:0016021; GO:0030198; GO:0031175; GO:0048167 0 0 0 PF00041;PF07679; P16157 CHOYP_TVAG_313830.2.4 m.35264 sp ANK1_HUMAN 40 185 111 0 488 672 373 557 1.11E-29 129 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_451090.1.13 m.21061 sp ANK1_HUMAN 35.762 302 176 2 52 353 240 523 1.11E-48 180 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17081 CHOYP_RHOQ.1.1 m.55541 sp RHOQ_HUMAN 38.421 190 105 3 10 189 10 197 1.11E-44 149 RHOQ_HUMAN reviewed Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A) RHOQ ARHQ RASL7A TC10 Homo sapiens (Human) 205 cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; GTP metabolic process [GO:0046039]; insulin receptor signaling pathway [GO:0008286]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005522; GO:0005525; GO:0005829; GO:0005884; GO:0005886; GO:0007264; GO:0008286; GO:0008360; GO:0030660; GO:0030866; GO:0032427; GO:0032869; GO:0032956; GO:0045121; GO:0045944; GO:0046039; GO:0046326; GO:0051056; GO:0051491; GO:0070062; GO:0090005 0 0 0 PF00071; P22105 CHOYP_MEG10.45.91 m.43988 sp TENX_HUMAN 26.58 696 320 56 50 701 197 745 1.11E-32 142 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P25291 CHOYP_BRAFLDRAFT_69120.2.3 m.33126 sp GP2_CANLF 33.858 127 73 5 45 166 32 152 1.11E-09 63.2 GP2_CANLF reviewed Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis lupus familiaris (Dog) (Canis familiaris) 509 0 GO:0005576; GO:0005886; GO:0031225 0 0 0 PF00100; P26591 CHOYP_GLRK.3.3 m.43688 sp GLRK_LYMST 32.112 573 327 14 7 540 3 552 1.11E-92 306 GLRK_LYMST reviewed Glutamate receptor 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 917 0 GO:0004970; GO:0005234; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF01094;PF00060;PF10613; P26779 CHOYP_LOC100372256.1.1 m.40879 sp SAP_BOVIN 30.039 516 264 13 426 885 51 525 1.11E-63 226 SAP_BOVIN reviewed Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] PSAP Bos taurus (Bovine) 525 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; glycosphingolipid metabolic process [GO:0006687]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216] GO:0001664; GO:0005615; GO:0005737; GO:0005764; GO:0006687; GO:0007193; GO:0008047; GO:0019216; GO:0060736; GO:0060742 0 0 0 PF02199;PF05184;PF03489; P34371 CHOYP_NEMVEDRAFT_V1G198958.6.6 m.60072 sp BAT42_CAEEL 26.923 130 94 1 40 168 220 349 1.11E-06 53.5 BAT42_CAEEL reviewed BTB and MATH domain-containing protein 42 bath-42 C50C3.8 Caenorhabditis elegans 410 protein ubiquitination [GO:0016567] GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00651; P35589 CHOYP_SYB.1.3 m.25801 sp SYB_APLCA 82.828 99 17 0 16 114 19 117 1.11E-43 143 SYB_APLCA reviewed Synaptobrevin 0 Aplysia californica (California sea hare) 180 vesicle-mediated transport [GO:0016192] GO:0016021; GO:0016192; GO:0030054; GO:0030672; GO:0043005 0 0 0 PF00957; P35658 CHOYP_NUP214.2.3 m.20892 sp NU214_HUMAN 36.341 399 237 10 5 391 11 404 1.11E-79 297 NU214_HUMAN reviewed Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) NUP214 CAIN CAN KIAA0023 Homo sapiens (Human) 2090 gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein sumoylation [GO:0016925]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of mRNA stability [GO:0043488]; RNA export from nucleus [GO:0006405]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005049; GO:0005634; GO:0005654; GO:0005829; GO:0005925; GO:0006405; GO:0006406; GO:0006409; GO:0006606; GO:0006611; GO:0007077; GO:0008139; GO:0010827; GO:0016032; GO:0016925; GO:0017056; GO:0019083; GO:0031047; GO:0043231; GO:0043488; GO:0051726; GO:0075733; GO:1900034; GO:1990876 0 0 0 0 P41436 CHOYP_IAP.2.2 m.64537 sp IAP_GVCPM 33.766 77 51 0 327 403 102 178 1.11E-06 53.5 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P55210 CHOYP_LOC100331324.1.3 m.5848 sp CASP7_HUMAN 27.376 263 143 11 12 254 67 301 1.11E-15 78.6 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P55214 CHOYP_LOC100375591.1.1 m.18559 sp CASP7_MESAU 28.438 320 189 10 96 403 10 301 1.11E-28 117 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 P98187 CHOYP_BRAFLDRAFT_61250.13.14 m.57254 sp CP4F8_HUMAN 38.178 516 289 11 4 500 14 518 1.11E-123 374 CP4F8_HUMAN reviewed Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016021; GO:0018685; GO:0019825; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q02067 CHOYP_ASCL1.2.2 m.11800 sp ASCL1_MOUSE 54.73 148 56 5 60 204 92 231 1.11E-31 117 ASCL1_MOUSE reviewed Achaete-scute homolog 1 (ASH-1) (mASH-1) (mASH1) Ascl1 Ash1 Mash-1 Mash1 Mus musculus (Mouse) 231 "adrenal chromaffin cell differentiation [GO:0061104]; carotid body glomus cell differentiation [GO:0061103]; cell differentiation [GO:0030154]; cell maturation [GO:0048469]; cellular response to magnetism [GO:0071259]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; cerebral cortex GABAergic interneuron differentiation [GO:0021892]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; enteric nervous system development [GO:0048484]; generation of neurons [GO:0048699]; glial cell differentiation [GO:0010001]; lung neuroendocrine cell differentiation [GO:0061100]; musculoskeletal movement, spinal reflex action [GO:0050883]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neuron development [GO:0048666]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; noradrenergic neuron development [GO:0003358]; noradrenergic neuron fate commitment [GO:0003359]; Notch signaling pathway [GO:0007219]; olfactory pit development [GO:0060166]; oligodendrocyte cell fate commitment [GO:0021779]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; parasympathetic nervous system development [GO:0048486]; pattern specification process [GO:0007389]; positive regulation of cell cycle [GO:0045787]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell proliferation [GO:0042127]; regulation of epithelial cell differentiation [GO:0030856]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of Notch signaling pathway [GO:0008593]; regulation of timing of subpallium neuron differentiation [GO:0060165]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to epidermal growth factor [GO:0070849]; response to folic acid [GO:0051593]; response to lithium ion [GO:0010226]; response to retinoic acid [GO:0032526]; spinal cord association neuron differentiation [GO:0021527]; spinal cord oligodendrocyte cell differentiation [GO:0021529]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; stomach neuroendocrine cell differentiation [GO:0061102]; subpallium neuron fate commitment [GO:0060163]; sympathetic ganglion development [GO:0061549]; sympathetic nervous system development [GO:0048485]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron fate commitment [GO:0060579]; vestibular nucleus development [GO:0021750]" GO:0000122; GO:0000977; GO:0000978; GO:0000989; GO:0001078; GO:0001764; GO:0003358; GO:0003359; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0007219; GO:0007346; GO:0007389; GO:0007400; GO:0007405; GO:0008593; GO:0010001; GO:0010226; GO:0010468; GO:0014003; GO:0021527; GO:0021529; GO:0021530; GO:0021750; GO:0021779; GO:0021892; GO:0021902; GO:0021954; GO:0021987; GO:0022008; GO:0030154; GO:0030182; GO:0030856; GO:0032526; GO:0042127; GO:0043025; GO:0043066; GO:0043425; GO:0043525; GO:0043565; GO:0045665; GO:0045666; GO:0045747; GO:0045787; GO:0045892; GO:0045944; GO:0048469; GO:0048484; GO:0048485; GO:0048486; GO:0048663; GO:0048665; GO:0048666; GO:0048699; GO:0048709; GO:0050767; GO:0050769; GO:0050883; GO:0051593; GO:0060163; GO:0060165; GO:0060166; GO:0060579; GO:0061100; GO:0061102; GO:0061103; GO:0061104; GO:0061549; GO:0070849; GO:0070888; GO:0071259; GO:0090575; GO:2000179 0 0 0 PF00010; Q02751 CHOYP_DPER_GL18144.1.1 m.58701 sp MALT_CANAX 33.962 106 63 4 9 109 431 534 1.11E-08 56.2 MALT_CANAX reviewed Alpha-glucosidase (EC 3.2.1.20) (Maltase) MAL2 MAL1 Candida albicans (Yeast) 570 0 GO:0004558; GO:0032450 0 0 0 PF00128; Q02763 CHOYP_SREC2.5.9 m.39825 sp TIE2_HUMAN 34.483 145 76 8 3 136 220 356 1.11E-16 82.8 TIE2_HUMAN reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 Homo sapiens (Human) 1124 angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; leukocyte migration [GO:0050900]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; organ regeneration [GO:0031100]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000165; GO:0001525; GO:0001666; GO:0001934; GO:0001935; GO:0001938; GO:0001958; GO:0002040; GO:0004672; GO:0004713; GO:0004714; GO:0004872; GO:0005088; GO:0005524; GO:0005576; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007165; GO:0007169; GO:0007267; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016323; GO:0016324; GO:0016525; GO:0018108; GO:0031100; GO:0032878; GO:0034446; GO:0043066; GO:0043114; GO:0043434; GO:0043552; GO:0043627; GO:0045121; GO:0045766; GO:0046777; GO:0048014; GO:0050728; GO:0050900; GO:0051259; GO:0051591; GO:0051894; GO:0051897; GO:0060216; GO:0060347; GO:0070374; GO:0072012; GO:1902533; GO:2000251; GO:2000351; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q0V9W6 CHOYP_BTBD3.3.3 m.14443 sp BTBD6_XENTR 25.522 431 301 9 11 437 113 527 1.11E-31 130 BTBD6_XENTR reviewed BTB/POZ domain-containing protein 6 btbd6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 529 0 GO:0000932 0 0 0 PF07707;PF00651;PF08005; Q0VAA2 CHOYP_LOC581313.2.2 m.46739 sp LR74A_HUMAN 34.031 191 119 5 188 375 151 337 1.11E-13 78.6 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q10741 CHOYP_LOC100101614.1.1 m.60411 sp ADA10_BOVIN 39.71 690 372 21 24 681 22 699 1.11E-161 487 ADA10_BOVIN reviewed Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (Myelin-associated metalloproteinase) (CD antigen CD156c) ADAM10 MADM Bos taurus (Bovine) 748 constitutive protein ectodomain proteolysis [GO:0051089]; in utero embryonic development [GO:0001701]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; Notch signaling pathway [GO:0007219]; PMA-inducible membrane protein ectodomain proteolysis [GO:0051088]; positive regulation of cell growth [GO:0030307]; positive regulation of cell proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; response to tumor necrosis factor [GO:0034612] GO:0000139; GO:0001701; GO:0004175; GO:0004222; GO:0005634; GO:0005737; GO:0005794; GO:0005798; GO:0005925; GO:0006468; GO:0006509; GO:0007162; GO:0007219; GO:0008237; GO:0008270; GO:0008284; GO:0009986; GO:0010820; GO:0014069; GO:0016021; GO:0016485; GO:0019901; GO:0030307; GO:0034612; GO:0042117; GO:0042803; GO:0051088; GO:0051089; GO:0070062; GO:0097038; GO:0097197 0 0 0 PF00200;PF01562; Q12802 CHOYP_AKP13.2.5 m.24402 sp AKP13_HUMAN 32.333 733 403 23 547 1235 1790 2473 1.11E-89 329 AKP13_HUMAN reviewed A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) 2813 adrenergic receptor signaling pathway [GO:0071875]; adrenergic receptor signaling pathway involved in heart process [GO:0086023]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; nuclear export [GO:0051168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cardiac muscle hypertrophy [GO:0010611]; regulation of glucocorticoid mediated signaling pathway [GO:1900169]; regulation of protein kinase activity [GO:0045859]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004691; GO:0004871; GO:0005078; GO:0005085; GO:0005089; GO:0005634; GO:0005737; GO:0005829; GO:0005938; GO:0007186; GO:0007507; GO:0010611; GO:0016020; GO:0017048; GO:0032947; GO:0035025; GO:0035556; GO:0043065; GO:0043123; GO:0045859; GO:0046872; GO:0048471; GO:0051018; GO:0051056; GO:0051168; GO:0055007; GO:0060297; GO:0060348; GO:0071875; GO:0086023; GO:1900169 0 0 0 PF00169;PF00621;PF10522; Q15699 CHOYP_LOC580069.1.1 m.10239 sp ALX1_HUMAN 41.328 271 133 7 54 308 58 318 1.11E-52 179 ALX1_HUMAN reviewed ALX homeobox protein 1 (Cartilage homeoprotein 1) (CART-1) ALX1 CART1 Homo sapiens (Human) 326 "anterior/posterior pattern specification [GO:0009952]; cartilage condensation [GO:0001502]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; multicellular organism development [GO:0007275]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; palate development [GO:0060021]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0000977; GO:0001228; GO:0001502; GO:0001755; GO:0001843; GO:0003700; GO:0003714; GO:0005634; GO:0005654; GO:0005667; GO:0005794; GO:0006366; GO:0007275; GO:0009952; GO:0010718; GO:0030326; GO:0045893; GO:0045944; GO:0048704; GO:0060021 0 0 0 PF00046;PF03826; Q17I16 CHOYP_LOC100494912.1.1 m.45483 sp WDY_AEDAE 22.063 349 224 11 128 452 40 364 1.11E-15 83.2 WDY_AEDAE reviewed WD repeat-containing protein on Y chromosome (WD40 Y) WDY AAEL002485 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 1037 0 0 0 0 0 PF00400; Q1EG27 CHOYP_LOC373229.1.3 m.21758 sp MYO3B_MOUSE 37.965 511 281 11 1 483 324 826 1.11E-95 318 MYO3B_MOUSE reviewed Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) 1305 peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0000146; GO:0001750; GO:0001917; GO:0004674; GO:0005524; GO:0005737; GO:0007601; GO:0016459; GO:0018105; GO:0018107; GO:0032426; GO:0032433; GO:0046777; GO:0050896; GO:0051491 0 0 0 PF00612;PF00063;PF00069; Q1MSJ5 CHOYP_MLLT4.1.1 m.66714 sp CSPP1_HUMAN 29.821 892 489 31 367 1214 97 895 1.11E-33 145 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q24537 CHOYP_PPP1R10.1.1 m.62374 sp HMG2_DROME 55.556 99 43 1 3 101 174 271 1.11E-29 112 HMG2_DROME reviewed High mobility group protein DSP1 (Protein dorsal switch 1) Dsp1 ssrp2 CG12223 Drosophila melanogaster (Fruit fly) 393 "chromatin remodeling [GO:0006338]; developmental process [GO:0032502]; DNA unwinding involved in DNA replication [GO:0006268]; leg disc development [GO:0035218]; negative regulation of antimicrobial humoral response [GO:0008348]; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0017055]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA binding [GO:0043388]; segment specification [GO:0007379]" GO:0000122; GO:0003677; GO:0003697; GO:0005634; GO:0005700; GO:0006268; GO:0006338; GO:0007379; GO:0008134; GO:0008301; GO:0008348; GO:0017025; GO:0017055; GO:0032502; GO:0035218; GO:0043388; GO:0045892 0 0 0 PF00505;PF09011; Q25145 CHOYP_TPM2.7.8 m.41069 sp TPM_HALRU 70.149 134 40 0 1 134 141 274 1.11E-53 172 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q25390 CHOYP_KLH36.2.2 m.48696 sp SCRA_LIMPO 28.387 310 208 7 808 1110 595 897 1.11E-29 131 SCRA_LIMPO reviewed Alpha-scruin 0 Limulus polyphemus (Atlantic horseshoe crab) 918 0 0 0 0 0 PF01344; Q28I29 CHOYP_DTWD1.1.1 m.49358 sp DTWD1_XENTR 42.222 315 118 8 1 309 28 284 1.11E-69 221 DTWD1_XENTR reviewed DTW domain-containing protein 1 dtwd1 TEgg073n17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 294 0 0 0 0 0 PF03942; Q2KJ44 CHOYP_PPP2R4.1.1 m.5975 sp PTPA_BOVIN 50.279 179 89 0 24 202 11 189 1.11E-62 200 PTPA_BOVIN reviewed "Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')" PPP2R4 Bos taurus (Bovine) 324 mitotic spindle organization in nucleus [GO:0030472]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphoprotein phosphatase activity [GO:0032516] GO:0000159; GO:0003755; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0008160; GO:0008601; GO:0016887; GO:0030472; GO:0032515; GO:0032516; GO:0034704; GO:0043065; GO:0070062 0 0 cd04087; PF03095; Q4R506 CHOYP_ISCW_ISCW004030.1.1 m.13863 sp RL7_MACFA 59.434 106 43 0 2 107 4 109 1.11E-30 112 RL7_MACFA reviewed 60S ribosomal protein L7 RPL7 QflA-14483 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 247 0 GO:0003723; GO:0005840 0 0 0 PF00327;PF08079; Q56A18 CHOYP_GLNA.2.5 m.1719 sp SMCE1_RAT 45.789 380 157 9 53 426 35 371 1.11E-91 287 SMCE1_RAT reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) Smarce1 Baf57 Rattus norvegicus (Rat) 376 "ATP-dependent chromatin remodeling [GO:0043044]; brain development [GO:0007420]; covalent chromatin modification [GO:0016569]; negative regulation of transcription, DNA-templated [GO:0045892]; spermatid development [GO:0007286]" GO:0003677; GO:0005634; GO:0007286; GO:0007420; GO:0016514; GO:0016569; GO:0043044; GO:0045892; GO:0047485 0 0 0 PF00505; Q5BIM1 CHOYP_LOC100370588.4.19 m.12562 sp TRI45_BOVIN 27.536 207 125 7 15 208 135 329 1.11E-08 60.1 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5GH57 CHOYP_BRAFLDRAFT_110042.2.2 m.17618 sp XKR6_RAT 26.915 483 268 15 45 493 74 505 1.11E-42 164 XKR6_RAT reviewed XK-related protein 6 Xkr6 Xrg6 Rattus norvegicus (Rat) 638 0 GO:0016020; GO:0016021 0 0 0 PF09815; Q5YLG1 CHOYP_LOC575405.1.1 m.18640 sp GUNA_BACPU 42.292 480 250 11 153 615 30 499 1.11E-101 325 GUNA_BACPU reviewed "Endoglucanase A (EC 3.2.1.4) (Endo-1,4-beta-glucanase A)" eglA Bacillus pumilus (Bacillus mesentericus) 659 cellulose catabolic process [GO:0030245] GO:0005576; GO:0008810; GO:0030245; GO:0030248 0 0 0 PF00942;PF00759; Q5ZJT1 CHOYP_LOC100377724.1.1 m.2899 sp HMCES_CHICK 43.75 112 57 2 10 118 186 294 1.11E-23 96.3 HMCES_CHICK reviewed Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein (ES cell-specific 5hmC-binding protein) (Putative peptidase SRAPD1) (EC 3.4.-.-) (SRAP domain-containing protein 1) HMCES SRAPD1 RCJMB04_15p13 Gallus gallus (Chicken) 336 0 GO:0003677; GO:0008233 0 0 0 PF02586; Q62656 CHOYP_LOC578045.3.5 m.59959 sp PTPRZ_RAT 26.101 318 203 9 1 298 1940 2245 1.11E-21 99 PTPRZ_RAT reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (3F8 chondroitin sulfate proteoglycan) (3H1 keratan sulfate proteoglycan) (Phosphacan) Ptprz1 Ptprz Ptpz Rattus norvegicus (Rat) 2316 axonal fasciculation [GO:0007413]; brain development [GO:0007420]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; neuron development [GO:0048666]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; protein dephosphorylation [GO:0006470]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0004725; GO:0005615; GO:0005737; GO:0006470; GO:0007413; GO:0007420; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0010976; GO:0016020; GO:0016021; GO:0016791; GO:0017134; GO:0021766; GO:0030027; GO:0030175; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048666; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; Q6AYG0 CHOYP_LOC100370823.1.3 m.29974 sp RRNAD_RAT 29.67 91 63 1 12 101 143 233 1.11E-07 55.8 RRNAD_RAT reviewed Protein RRNAD1 Rrnad1 Rattus norvegicus (Rat) 475 0 GO:0016021 0 0 0 PF13679; Q6GLJ1 CHOYP_LOC654854.1.1 m.24535 sp BTBDH_XENLA 22.863 503 303 17 12 499 26 458 1.11E-27 119 BTBDH_XENLA reviewed BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) 470 0 GO:0005576 0 0 0 PF07707;PF00651; Q6GLT8 CHOYP_OSBL9.2.2 m.35247 sp FAHD2_XENLA 55.738 244 107 1 1 244 57 299 1.11E-100 298 FAHD2_XENLA reviewed Fumarylacetoacetate hydrolase domain-containing protein 2 (EC 3.-.-.-) fahd2 fahd2a Xenopus laevis (African clawed frog) 319 metabolic process [GO:0008152] GO:0008152; GO:0016787; GO:0046872 0 0 0 PF01557; Q6R7E2 CHOYP_BIR1G.2.2 m.35232 sp IAP2_OSHVF 35.149 202 93 7 55 251 2 170 1.11E-27 107 IAP2_OSHVF reviewed Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 170 0 0 0 0 0 PF00653; Q6X936 CHOYP_LOC100906218.1.1 m.16334 sp KIRR1_RAT 31.927 545 344 10 11 548 35 559 1.11E-80 276 KIRR1_RAT reviewed Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Kirrel Kirrel1 Neph1 Rattus norvegicus (Rat) 789 excretion [GO:0007588]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of actin filament polymerization [GO:0030838]; single organismal cell-cell adhesion [GO:0016337] GO:0001933; GO:0005911; GO:0007588; GO:0016021; GO:0016337; GO:0030838; GO:0031253; GO:0043198; GO:0045121; GO:0048471; GO:0070062 0 0 0 PF08205;PF07679; Q75WF2 CHOYP_DNASE2.1.1 m.3364 sp DNA2_ACAPL 32.41 361 213 10 8 348 8 357 1.11E-54 186 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q7LZR2 CHOYP_CO8A1.1.1 m.40227 sp CO8A1_CHICK 33.077 130 82 3 52 179 612 738 1.11E-10 62.8 CO8A1_CHICK reviewed Collagen alpha-1(VIII) chain COL8A1 Gallus gallus (Chicken) 744 angiogenesis [GO:0001525]; cell adhesion [GO:0007155] GO:0001525; GO:0005581; GO:0005604; GO:0007155 0 0 0 PF00386;PF01391; Q7T0Y4 CHOYP_LOC575509.1.2 m.50473 sp DRC1_XENLA 51.896 501 196 8 76 576 231 686 1.11E-156 467 DRC1_XENLA reviewed Dynein regulatory complex protein 1 (Coiled-coil domain-containing protein 164) drc1 ccdc164 Xenopus laevis (African clawed frog) 690 axonemal dynein complex assembly [GO:0070286]; bacterial-type flagellum-dependent cell motility [GO:0071973]; cilium-dependent cell motility [GO:0060285] GO:0005737; GO:0005930; GO:0060285; GO:0070286; GO:0071973 0 0 0 PF14775; Q80T91 CHOYP_LOC100701872.4.7 m.33134 sp MEG11_MOUSE 37.037 243 127 11 30 260 424 652 1.11E-28 120 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8BGI1 CHOYP_ZGC_175214.1.2 m.56719 sp RNF24_MOUSE 43.81 105 56 2 4 105 18 122 1.11E-23 92.4 RNF24_MOUSE reviewed RING finger protein 24 Rnf24 Mus musculus (Mouse) 148 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000139; GO:0000209; GO:0008270; GO:0016021; GO:0042787; GO:0043161; GO:0061630 0 0 0 PF13639; Q8BGI1 CHOYP_ZGC_175214.2.2 m.60643 sp RNF24_MOUSE 43.81 105 56 2 4 105 18 122 1.11E-23 92.4 RNF24_MOUSE reviewed RING finger protein 24 Rnf24 Mus musculus (Mouse) 148 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000139; GO:0000209; GO:0008270; GO:0016021; GO:0042787; GO:0043161; GO:0061630 0 0 0 PF13639; Q8CE13 CHOYP_BRAFLDRAFT_126355.2.2 m.57963 sp CCD17_MOUSE 26.84 462 297 11 152 600 87 520 1.11E-27 122 CCD17_MOUSE reviewed Coiled-coil domain-containing protein 17 Ccdc17 Mus musculus (Mouse) 565 0 0 0 0 0 0 Q8K0U4 CHOYP_LOC100223480.3.4 m.36209 sp HS12A_MOUSE 29.813 587 329 18 31 546 50 624 1.11E-62 221 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K1S5 CHOYP_LOC590249.1.1 m.4654 sp KLF11_MOUSE 64.655 116 40 1 316 431 355 469 1.11E-45 168 KLF11_MOUSE reviewed Krueppel-like factor 11 (TGFB-inducible early growth response protein 2b) (Transforming growth factor-beta-inducible early growth response protein 3) (TGFB-inducible early growth response protein 3) (TIEG-3) Klf11 Tieg2b Tieg3 Mus musculus (Mouse) 502 "apoptotic process [GO:0006915]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; transcription, DNA-templated [GO:0006351]" GO:0000083; GO:0000122; GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006915; GO:0008285; GO:0043065; GO:0044212; GO:0045892; GO:0046872 0 0 0 PF00096; Q8NCJ5 CHOYP_SPRY3.1.1 m.39963 sp SPRY3_HUMAN 55.875 417 145 8 48 442 43 442 1.11E-148 433 SPRY3_HUMAN reviewed SPRY domain-containing protein 3 SPRYD3 Homo sapiens (Human) 442 0 0 0 0 0 PF00622; Q8NEV4 CHOYP_LOC373229.3.3 m.62445 sp MYO3A_HUMAN 37.022 759 441 13 10 755 341 1075 1.11E-151 499 MYO3A_HUMAN reviewed Myosin-IIIa (EC 2.7.11.1) MYO3A Homo sapiens (Human) 1616 protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0000146; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0007601; GO:0007605; GO:0016459; GO:0030175; GO:0030898; GO:0031941; GO:0043531; GO:0046777; GO:0050896; GO:0060002 0 0 0 PF00612;PF00063;PF00069; Q8NEV4 CHOYP_MYO3.1.2 m.6025 sp MYO3A_HUMAN 43.612 227 126 1 12 236 924 1150 1.11E-51 194 MYO3A_HUMAN reviewed Myosin-IIIa (EC 2.7.11.1) MYO3A Homo sapiens (Human) 1616 protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0000146; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0007601; GO:0007605; GO:0016459; GO:0030175; GO:0030898; GO:0031941; GO:0043531; GO:0046777; GO:0050896; GO:0060002 0 0 0 PF00612;PF00063;PF00069; Q8QGX4 CHOYP_BRAFLDRAFT_85202.1.2 m.18410 sp PRKDC_CHICK 44.306 641 335 10 1 625 713 1347 1.11E-175 557 PRKDC_CHICK reviewed DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC XRCC7 Gallus gallus (Chicken) 4134 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431] GO:0000724; GO:0003677; GO:0004677; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006281; GO:0006303; GO:0016301; GO:0070419; GO:0072431 0 0 0 PF02259;PF02260;PF08163;PF00454; Q8R0A7 CHOYP_LOC100881532.1.1 m.16034 sp K0513_MOUSE 40 200 97 5 288 477 6 192 1.11E-32 133 K0513_MOUSE reviewed Uncharacterized protein KIAA0513 Kiaa0513 Mus musculus (Mouse) 407 0 0 0 0 0 0 Q8R420 CHOYP_ABCA3.3.6 m.27302 sp ABCA3_MOUSE 38.686 548 290 12 2 511 5 544 1.11E-113 372 ABCA3_MOUSE reviewed ATP-binding cassette sub-family A member 3 Abca3 Mus musculus (Mouse) 1704 lipid transport [GO:0006869]; response to glucocorticoid [GO:0051384]; transport [GO:0006810] GO:0005524; GO:0005615; GO:0005886; GO:0006810; GO:0006869; GO:0016021; GO:0042626; GO:0051384; GO:0097208; GO:0097233 0 0 0 PF00005; Q8WZA0 CHOYP_LZIC.1.1 m.53062 sp LZIC_HUMAN 66.667 189 63 0 8 196 2 190 1.11E-86 256 LZIC_HUMAN reviewed Protein LZIC (Leucine zipper and CTNNBIP1 domain-containing protein) (Leucine zipper and ICAT homologous domain-containing protein) LZIC Homo sapiens (Human) 190 response to ionizing radiation [GO:0010212] GO:0010212 0 0 0 PF06384; Q90YS3 CHOYP_RS2.4.10 m.21705 sp RS2_ICTPU 80.645 248 43 1 1 248 20 262 1.11E-142 404 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q94519 CHOYP_RS17.10.11 m.58728 sp ACPM_DROME 53.153 111 48 1 44 150 42 152 1.11E-36 126 ACPM_DROME reviewed "Acyl carrier protein, mitochondrial (ACP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit) (NADH-ubiquinone oxidoreductase acyl-carrier subunit)" ND-ACP mtACP mtacp1 ND-AcC CG9160 Drosophila melanogaster (Fruit fly) 152 "fatty acid biosynthetic process [GO:0006633]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; regulation of glucose metabolic process [GO:0010906]; sensory perception of pain [GO:0019233]" GO:0000036; GO:0005739; GO:0006120; GO:0006633; GO:0010906; GO:0019233; GO:0031177; GO:0070469 0 0 0 PF00550; Q96GP6 CHOYP_MEGF6.21.59 m.33043 sp SREC2_HUMAN 38.462 182 105 6 53 234 245 419 1.11E-24 105 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208436.32.32 m.65222 sp HS12B_HUMAN 34.135 665 356 18 7 599 32 686 1.11E-116 365 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96RW7 CHOYP_LOC100650970.1.1 m.14901 sp HMCN1_HUMAN 26.655 559 318 27 134 627 785 1316 1.11E-20 102 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99020 CHOYP_LIX1L.1.1 m.59788 sp ROAA_MOUSE 60.135 148 58 1 2 149 70 216 1.11E-54 178 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q99MR1 CHOYP_PERQ2.1.2 m.1487 sp PERQ1_MOUSE 43.925 321 140 13 28 317 3 314 1.11E-47 189 PERQ1_MOUSE reviewed PERQ amino acid-rich with GYF domain-containing protein 1 (GRB10-interacting GYF protein 1) Gigyf1 Kiaa4110 Perq1 Mus musculus (Mouse) 1044 insulin-like growth factor receptor signaling pathway [GO:0048009] GO:0048009 0 0 0 PF02213; Q9BZR6 CHOYP_CAOG_08239.3.3 m.58712 sp RTN4R_HUMAN 29.641 334 194 8 12 311 8 334 1.11E-38 145 RTN4R_HUMAN reviewed Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) RTN4R NOGOR UNQ330/PRO526 Homo sapiens (Human) 473 axonogenesis [GO:0007409]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of axon extension [GO:0030517]; negative regulation of axonogenesis [GO:0050771]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; neuronal signal transduction [GO:0023041]; positive regulation of GTPase activity [GO:0043547] GO:0004860; GO:0004872; GO:0005737; GO:0005783; GO:0005886; GO:0005887; GO:0006469; GO:0007409; GO:0009986; GO:0019221; GO:0023041; GO:0030517; GO:0031225; GO:0038131; GO:0043005; GO:0043025; GO:0043547; GO:0044295; GO:0046426; GO:0050771; GO:0070062 0 0 0 PF13855; Q9CYL5 CHOYP_ISCW_ISCW019177.4.4 m.63940 sp GAPR1_MOUSE 44.681 94 47 2 82 175 2 90 1.11E-16 75.9 GAPR1_MOUSE reviewed Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) Glipr2 Gapr1 Mus musculus (Mouse) 154 positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374 0 0 0 PF00188; Q9D1D4 CHOYP_TMEDA.2.2 m.48568 sp TMEDA_MOUSE 69.154 201 56 2 49 245 21 219 1.11E-96 285 TMEDA_MOUSE reviewed Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1) Tmed10 Tmp21 Mus musculus (Mouse) 219 "COPI-coated vesicle budding [GO:0035964]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; protein oligomerization [GO:0051259]; regulated exocytosis [GO:0045055]; regulation of beta-amyloid formation [GO:1902003]; response to alkaloid [GO:0043279]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle targeting, to, from or within Golgi [GO:0048199]" GO:0000139; GO:0001822; GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0005801; GO:0005886; GO:0006886; GO:0006890; GO:0007030; GO:0016021; GO:0019905; GO:0030137; GO:0030140; GO:0030658; GO:0030667; GO:0033116; GO:0035964; GO:0042470; GO:0042589; GO:0043279; GO:0045055; GO:0048199; GO:0051259; GO:0070062; GO:0070765; GO:1902003 0 0 0 PF01105; Q9D2Q3 CHOYP_LOC100123888.1.1 m.52920 sp CJ088_MOUSE 21.774 372 216 9 64 389 69 411 1.11E-08 60.5 CJ088_MOUSE reviewed Uncharacterized protein C10orf88 homolog 0 Mus musculus (Mouse) 444 0 GO:0042802 0 0 0 PF14958; Q9DCG9 CHOYP_NEMVEDRAFT_V1G80846.1.1 m.24713 sp TR112_MOUSE 48.387 124 63 1 4 127 1 123 1.11E-35 122 TR112_MOUSE reviewed Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) Trmt112 Mus musculus (Mouse) 125 peptidyl-glutamine methylation [GO:0018364]; rRNA (guanine-N7)-methylation [GO:0070476]; tRNA methylation [GO:0030488] GO:0008276; GO:0018364; GO:0030488; GO:0043234; GO:0070062; GO:0070476 0 0 0 PF03966; Q9DG68 CHOYP_RLA0.3.7 m.42196 sp RLA0_RANSY 67.937 315 100 1 1 314 1 315 1.11E-147 420 RLA0_RANSY reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) 315 ribosome biogenesis [GO:0042254] GO:0005840; GO:0042254 0 0 0 PF00466; Q9DG68 CHOYP_RLA0.5.7 m.56221 sp RLA0_RANSY 67.937 315 100 1 1 314 1 315 1.11E-147 420 RLA0_RANSY reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) 315 ribosome biogenesis [GO:0042254] GO:0005840; GO:0042254 0 0 0 PF00466; Q9HC07 CHOYP_CPIPJ_CPIJ004440.1.1 m.62518 sp TM165_HUMAN 57.394 284 94 6 29 287 37 318 1.11E-109 323 TM165_HUMAN reviewed Transmembrane protein 165 (Transmembrane protein PT27) (Transmembrane protein TPARL) TMEM165 TPARL Homo sapiens (Human) 324 cellular calcium ion homeostasis [GO:0006874]; Golgi calcium ion transport [GO:0032472]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751] GO:0005765; GO:0005794; GO:0006487; GO:0006874; GO:0010008; GO:0016021; GO:0031901; GO:0031902; GO:0032472; GO:0032588; GO:0035751; GO:0043231 0 0 0 PF01169; Q9HCK4 CHOYP_HMCN1.8.44 m.23142 sp ROBO2_HUMAN 32.468 154 90 6 27 180 188 327 1.11E-09 60.5 ROBO2_HUMAN reviewed Roundabout homolog 2 ROBO2 KIAA1568 Homo sapiens (Human) 1378 apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; positive regulation of axonogenesis [GO:0050772]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657] GO:0001656; GO:0001657; GO:0007156; GO:0007411; GO:0007417; GO:0007420; GO:0008046; GO:0009986; GO:0016021; GO:0016199; GO:0021891; GO:0030673; GO:0031290; GO:0032870; GO:0035385; GO:0042802; GO:0050772; GO:0050925; GO:0051964; GO:0061364; GO:0070062 0 0 0 PF00041;PF07679; Q9JJP6 CHOYP_BRAFLDRAFT_67483.1.1 m.55096 sp P63_RAT 36.758 623 312 19 16 576 50 652 1.11E-108 343 P63_RAT reviewed Tumor protein 63 (p63) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) Tp63 Ket P63 Tp73l Trp63 Rattus norvegicus (Rat) 680 "cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; ectoderm and mesoderm interaction [GO:0007499]; embryonic limb morphogenesis [GO:0030326]; epidermal cell division [GO:0010481]; epithelial cell development [GO:0002064]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mitotic G1 DNA damage checkpoint [GO:0031571]; multicellular organism aging [GO:0010259]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; prostatic bud formation [GO:0060513]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of epidermal cell division [GO:0010482]; regulation of neuron apoptotic process [GO:0043523]; replicative cell aging [GO:0001302]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; sympathetic nervous system development [GO:0048485]; urinary bladder development [GO:0060157]" GO:0000122; GO:0000785; GO:0000790; GO:0000989; GO:0001077; GO:0001302; GO:0001501; GO:0001736; GO:0002039; GO:0002053; GO:0002064; GO:0003682; GO:0003684; GO:0003690; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005791; GO:0005829; GO:0006338; GO:0006978; GO:0007219; GO:0007283; GO:0007499; GO:0009954; GO:0010165; GO:0010259; GO:0010332; GO:0010481; GO:0010482; GO:0010838; GO:0019904; GO:0030216; GO:0030326; GO:0030425; GO:0030859; GO:0031069; GO:0031571; GO:0034644; GO:0036342; GO:0042475; GO:0042771; GO:0043005; GO:0043066; GO:0043234; GO:0043281; GO:0043523; GO:0043565; GO:0043589; GO:0043616; GO:0044212; GO:0045617; GO:0045669; GO:0045747; GO:0045944; GO:0046872; GO:0048485; GO:0048745; GO:0048807; GO:0051289; GO:0051402; GO:0060157; GO:0060197; GO:0060513; GO:0060529; GO:0061436; GO:1902808; GO:2000271; GO:2000381; GO:2000773; GO:2001235 0 0 cd08367; PF00870;PF07710;PF07647; Q9JJP6 CHOYP_HSP7D.2.3 m.34783 sp P63_RAT 36.758 623 312 19 16 576 50 652 1.11E-108 343 P63_RAT reviewed Tumor protein 63 (p63) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) Tp63 Ket P63 Tp73l Trp63 Rattus norvegicus (Rat) 680 "cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; ectoderm and mesoderm interaction [GO:0007499]; embryonic limb morphogenesis [GO:0030326]; epidermal cell division [GO:0010481]; epithelial cell development [GO:0002064]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mitotic G1 DNA damage checkpoint [GO:0031571]; multicellular organism aging [GO:0010259]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; prostatic bud formation [GO:0060513]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of epidermal cell division [GO:0010482]; regulation of neuron apoptotic process [GO:0043523]; replicative cell aging [GO:0001302]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; sympathetic nervous system development [GO:0048485]; urinary bladder development [GO:0060157]" GO:0000122; GO:0000785; GO:0000790; GO:0000989; GO:0001077; GO:0001302; GO:0001501; GO:0001736; GO:0002039; GO:0002053; GO:0002064; GO:0003682; GO:0003684; GO:0003690; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005791; GO:0005829; GO:0006338; GO:0006978; GO:0007219; GO:0007283; GO:0007499; GO:0009954; GO:0010165; GO:0010259; GO:0010332; GO:0010481; GO:0010482; GO:0010838; GO:0019904; GO:0030216; GO:0030326; GO:0030425; GO:0030859; GO:0031069; GO:0031571; GO:0034644; GO:0036342; GO:0042475; GO:0042771; GO:0043005; GO:0043066; GO:0043234; GO:0043281; GO:0043523; GO:0043565; GO:0043589; GO:0043616; GO:0044212; GO:0045617; GO:0045669; GO:0045747; GO:0045944; GO:0046872; GO:0048485; GO:0048745; GO:0048807; GO:0051289; GO:0051402; GO:0060157; GO:0060197; GO:0060513; GO:0060529; GO:0061436; GO:1902808; GO:2000271; GO:2000381; GO:2000773; GO:2001235 0 0 cd08367; PF00870;PF07710;PF07647; Q9UIF3 CHOYP_BRAFLDRAFT_123537.1.2 m.28823 sp TEKT2_HUMAN 62.869 237 87 1 1 236 1 237 1.11E-100 302 TEKT2_HUMAN reviewed Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1) TEKT2 Homo sapiens (Human) 430 inner dynein arm assembly [GO:0036159]; sperm motility [GO:0030317] GO:0005634; GO:0005737; GO:0005874; GO:0030317; GO:0031514; GO:0036159 0 0 0 0 Q9V477 CHOYP_TLR4.3.4 m.39054 sp TOLL8_DROME 36.269 193 107 4 448 629 1022 1209 1.11E-29 129 TOLL8_DROME reviewed Toll-like receptor Tollo (Toll-like receptor 8) Tollo Tl-8 Toll-8 CG6890 Drosophila melanogaster (Fruit fly) 1346 axis elongation [GO:0003401]; convergent extension [GO:0060026]; innate immune response in mucosa [GO:0002227]; peripheral nervous system neuron development [GO:0048935]; regulation of glucose metabolic process [GO:0010906]; regulation of protein glycosylation [GO:0060049]; signal transduction [GO:0007165] GO:0002227; GO:0003401; GO:0007165; GO:0010906; GO:0016021; GO:0016324; GO:0048935; GO:0060026; GO:0060049 0 0 0 PF13306;PF13855;PF01582; Q9VBP3 CHOYP_BRAFLDRAFT_74874.7.9 m.55966 sp TNKS_DROME 29.358 218 91 6 525 731 1003 1168 1.11E-14 82 TNKS_DROME reviewed Tankyrase (dTNKS) (EC 2.4.2.30) (Poly [ADP-ribose] polymerase) Tnks tankyrase CG4719 Drosophila melanogaster (Fruit fly) 1181 chaeta development [GO:0022416]; protein ADP-ribosylation [GO:0006471]; regulation of proteasome assembly [GO:0090364]; wing disc development [GO:0035220] GO:0003950; GO:0006471; GO:0022416; GO:0035220; GO:0046872; GO:0090364; GO:0097110 0 0 0 PF00023;PF12796;PF00644;PF07647; Q9W5U2 CHOYP_AGAP_AGAP011617.2.2 m.43328 sp CHIT3_DROME 24.869 382 221 20 414 749 553 914 1.11E-08 62.8 CHIT3_DROME reviewed Probable chitinase 3 (EC 3.2.1.14) (Probable chitinase 1) Cht3 Cht1 CG18140 Drosophila melanogaster (Fruit fly) 2286 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0006032; GO:0008061 0 0 0 PF01607;PF00704; Q9Y2M2 CHOYP_BRAFLDRAFT_276314.1.3 m.42632 sp SSUH2_HUMAN 31.915 329 213 5 57 379 29 352 1.11E-55 189 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 A2A7Y5 CHOYP_MIIP.1.1 m.24459 sp MIIP_MOUSE 37.056 197 100 8 249 437 145 325 1.12E-21 100 MIIP_MOUSE reviewed Migration and invasion-inhibitory protein (Invasion-inhibitory protein 45) (IIp45) Miip D4Wsu114e Iip45 Mus musculus (Mouse) 387 negative regulation of cell migration [GO:0030336]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972] GO:0010972; GO:0030336 0 0 0 PF15734; A2RRX6 CHOYP_LOC100867228.1.1 m.8309 sp NPAT_XENLA 33.071 127 78 2 8 131 2 124 1.12E-10 71.2 NPAT_XENLA reviewed Protein NPAT npat Xenopus laevis (African clawed frog) 1356 "cell cycle [GO:0007049]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0007049; GO:0015030; GO:0097504 0 0 0 PF15712; B2RY56 CHOYP_RBM25.1.2 m.41094 sp RBM25_MOUSE 60.934 407 145 7 371 765 434 838 1.12E-109 356 RBM25_MOUSE reviewed RNA-binding protein 25 (RNA-binding motif protein 25) Rbm25 Mus musculus (Mouse) 838 "apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003729; GO:0005681; GO:0005737; GO:0006397; GO:0006915; GO:0008380; GO:0016607; GO:0042981 0 0 0 PF01480;PF00076; H2A0L8 CHOYP_FND2.4.4 m.44570 sp FND2_PINMG 47.241 580 279 7 26 582 39 614 1.12E-158 475 FND2_PINMG reviewed Fibronectin type III domain-containing protein 2 0 Pinctada margaritifera (Black-lipped pearl oyster) 624 0 GO:0005576 0 0 0 PF00041; H2A0M7 CHOYP_LOC660719.1.1 m.16592 sp PLSP_PINMG 36.921 604 337 15 162 735 144 733 1.12E-108 352 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O14522 CHOYP_PTPRT.41.45 m.61845 sp PTPRT_HUMAN 34.483 290 179 5 5 291 803 1084 1.12E-46 172 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O35723 CHOYP_DNAJB6B.1.2 m.1265 sp DNJB3_MOUSE 42.857 287 107 8 3 285 2 235 1.12E-49 167 DNJB3_MOUSE reviewed DnaJ homolog subfamily B member 3 (DnaJ protein homolog 3) (Heat shock protein J3) (HSJ-3) (MSJ-1) Dnajb3 Hsj3 Msj1 Mus musculus (Mouse) 242 0 GO:0005737; GO:0005813 0 0 cd06257; PF00226; O46339 CHOYP_MEIS2.2.4 m.12342 sp HTH_DROME 60.256 156 36 4 12 167 340 469 1.12E-48 171 HTH_DROME reviewed Homeobox protein homothorax (Homeobox protein dorsotonals) hth dtl CG17117 Drosophila melanogaster (Fruit fly) 487 "brain development [GO:0007420]; compound eye development [GO:0048749]; compound eye photoreceptor fate commitment [GO:0001752]; eye development [GO:0001654]; haltere morphogenesis [GO:0048735]; head morphogenesis [GO:0060323]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing morphogenesis [GO:0007476]; leg disc proximal/distal pattern formation [GO:0007479]; peripheral nervous system development [GO:0007422]; positive regulation of decapentaplegic signaling pathway [GO:0090098]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein import into nucleus, translocation [GO:0000060]; protein localization to nucleus [GO:0034504]; proximal/distal pattern formation [GO:0009954]; regulation of cell fate specification [GO:0042659]; regulation of neuron differentiation [GO:0045664]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; salivary gland boundary specification [GO:0007432]; segmentation [GO:0035282]; somatic muscle development [GO:0007525]; specification of organ identity [GO:0010092]; specification of segmental identity, antennal segment [GO:0007383]; specification of segmental identity, head [GO:0007380]" GO:0000060; GO:0001654; GO:0001752; GO:0003677; GO:0003700; GO:0003705; GO:0005634; GO:0005667; GO:0005737; GO:0005829; GO:0006357; GO:0007380; GO:0007383; GO:0007420; GO:0007422; GO:0007432; GO:0007476; GO:0007479; GO:0007480; GO:0007525; GO:0008134; GO:0009954; GO:0010092; GO:0034504; GO:0035282; GO:0035326; GO:0042659; GO:0045664; GO:0045944; GO:0048735; GO:0048749; GO:0060323; GO:0090098 0 0 0 PF05920;PF16493; O75179 CHOYP_LOC100641396.17.27 m.47283 sp ANR17_HUMAN 31.157 536 319 16 3 522 222 723 1.12E-51 194 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O97817 CHOYP_LOC100702950.3.4 m.24542 sp AGRL2_BOVIN 22.922 397 242 16 194 552 465 835 1.12E-17 90.9 AGRL2_BOVIN reviewed Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin-2) ADGRL2 LPH2 LPHN2 Bos taurus (Bovine) 1478 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0007166; GO:0016021; GO:0030246 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; P07207 CHOYP_CSPG2.1.1 m.37489 sp NOTCH_DROME 58.824 68 23 1 25 87 1172 1239 1.12E-19 85.9 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P0C5Y8 CHOYP_LOC580872.1.1 m.32365 sp ALS2_RAT 54.945 91 40 1 18 108 1342 1431 1.12E-24 100 ALS2_RAT reviewed Alsin (Amyotrophic lateral sclerosis 2 protein homolog) Als2 Rattus norvegicus (Rat) 1651 "axonogenesis [GO:0007409]; behavioral fear response [GO:0001662]; cell death [GO:0008219]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; in utero embryonic development [GO:0001701]; locomotory behavior [GO:0007626]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; protein localization [GO:0008104]; Rac protein signal transduction [GO:0016601]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; regulation of Rho protein signal transduction [GO:0035023]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]; vesicle organization [GO:0016050]" GO:0001662; GO:0001701; GO:0001726; GO:0001881; GO:0005737; GO:0005769; GO:0005813; GO:0005829; GO:0006979; GO:0007032; GO:0007409; GO:0007528; GO:0007626; GO:0008104; GO:0008219; GO:0014069; GO:0016020; GO:0016050; GO:0016197; GO:0016601; GO:0017112; GO:0017137; GO:0030027; GO:0030424; GO:0030425; GO:0030426; GO:0030676; GO:0031982; GO:0035023; GO:0035249; GO:0042803; GO:0043005; GO:0043025; GO:0043197; GO:0043231; GO:0043234; GO:0043539; GO:0043547; GO:0045860; GO:0048812; GO:0051036 0 0 0 PF02493;PF00415;PF00621;PF02204; P10079 CHOYP_LOC100632098.2.13 m.12501 sp FBP1_STRPU 55.914 372 164 0 1 372 186 557 1.12E-126 392 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P15880 CHOYP_BRAFLDRAFT_275374.1.3 m.17725 sp RS2_HUMAN 85.714 84 12 0 41 124 54 137 1.12E-44 150 RS2_HUMAN reviewed 40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) RPS2 RPS4 Homo sapiens (Human) 293 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of transferase activity [GO:0051347]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003729; GO:0003735; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005913; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0017134; GO:0019083; GO:0019899; GO:0022627; GO:0044822; GO:0051347; GO:0070062; GO:0098641 0 0 0 PF00333;PF03719; P18173 CHOYP_LOC100118063.1.4 m.16640 sp DHGL_DROME 41.135 564 300 14 38 593 65 604 1.12E-123 381 DHGL_DROME reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) 625 glucose metabolic process [GO:0006006]; pupal chitin-based cuticle development [GO:0008364]; sensory perception of pain [GO:0019233]; sperm storage [GO:0046693] GO:0005576; GO:0006006; GO:0008364; GO:0016614; GO:0019233; GO:0046693; GO:0050660 0 0 0 PF05199;PF00732; P18433 CHOYP_PTPRT.30.45 m.53464 sp PTPRA_HUMAN 29.279 666 430 19 373 1013 151 800 1.12E-80 283 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P21328 CHOYP_LOC752194.7.12 m.35363 sp RTJK_DROME 25.314 478 313 13 46 505 364 815 1.12E-32 136 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P21329 CHOYP_LOC100561123.7.28 m.10241 sp RTJK_DROFU 28.094 299 202 4 18 309 438 730 1.12E-28 119 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P22232 CHOYP_LOC591797.3.3 m.57371 sp FBRL_XENLA 83.761 234 38 0 85 318 88 321 1.12E-147 421 FBRL_XENLA reviewed rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Histone-glutamine methyltransferase) fbl Xenopus laevis (African clawed frog) 323 histone glutamine methylation [GO:1990258]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] GO:0003723; GO:0005730; GO:0006364; GO:0008033; GO:0030529; GO:1990258; GO:1990259 0 0 0 PF01269; P23398 CHOYP_BRAFLDRAFT_125432.1.1 m.50347 sp UBIQP_STRPU 90.11 91 7 2 1 91 44 132 1.12E-48 154 UBIQP_STRPU reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 133 0 GO:0005634; GO:0005737 0 0 0 PF00240; P23416 CHOYP_BRAFLDRAFT_79146.1.1 m.16771 sp GLRA2_HUMAN 37.799 418 228 7 46 434 37 451 1.12E-96 301 GLRA2_HUMAN reviewed Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) 452 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glycinergic [GO:0060012]" GO:0005886; GO:0005887; GO:0007218; GO:0007416; GO:0016594; GO:0016934; GO:0021510; GO:0022852; GO:0030054; GO:0034220; GO:0034707; GO:0042995; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; P27161 CHOYP_LOC101243958.1.1 m.28316 sp CALM_SOLLC 49.63 135 64 2 37 168 13 146 1.12E-36 129 CALM_SOLLC reviewed Calmodulin (CaM) CALM1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) 149 0 GO:0005509 0 0 0 PF13499; P28824 CHOYP_LOC100897343.1.1 m.737 sp NRP1_XENLA 30.769 182 99 11 1513 1685 431 594 1.12E-08 63.9 NRP1_XENLA reviewed Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) 928 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; endothelial cell chemotaxis [GO:0035767]; organ morphogenesis [GO:0009887]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005021; GO:0007411; GO:0008201; GO:0009887; GO:0016021; GO:0017154; GO:0035767; GO:0046872; GO:0048010 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P29145 CHOYP_LOC100202203.1.1 m.27309 sp NECB_HYDVU 44.484 562 261 8 46 601 91 607 1.12E-154 471 NECB_HYDVU reviewed PC3-like endoprotease variant B (EC 3.4.21.-) (SPC3) 0 Hydra vulgaris (Hydra) (Hydra attenuata) 710 0 GO:0004252 0 0 0 PF01483;PF00082;PF16470; P29314 CHOYP_RS9.10.13 m.48531 sp RS9_RAT 89.474 171 14 1 5 171 1 171 1.12E-106 307 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P48542 CHOYP_LOC101168316.1.1 m.11121 sp KCNJ6_MOUSE 40.566 318 184 3 39 355 59 372 1.12E-84 271 KCNJ6_MOUSE reviewed "G protein-activated inward rectifier potassium channel 2 (GIRK-2) (Inward rectifier K(+) channel Kir3.2) (Potassium channel, inwardly rectifying subfamily J member 6)" Kcnj6 Girk2 Kcnj7 W Mus musculus (Mouse) 425 potassium ion import [GO:0010107] GO:0005794; GO:0005886; GO:0005887; GO:0010107; GO:0015467 0 0 0 PF01007; P49013 CHOYP_BRAFLDRAFT_63459.2.3 m.27933 sp FBP3_STRPU 39.502 281 112 11 700 942 180 440 1.12E-40 162 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P56494 CHOYP_contig_039329 m.44539 sp OXYR_MACMU 21.652 351 235 10 11 358 33 346 1.12E-07 56.6 OXYR_MACMU reviewed Oxytocin receptor (OT-R) OXTR Macaca mulatta (Rhesus macaque) 389 cellular response to hormone stimulus [GO:0032870]; female pregnancy [GO:0007565]; lactation [GO:0007595]; maternal behavior [GO:0042711]; positive regulation of blood pressure [GO:0045777]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; response to peptide [GO:1901652]; social behavior [GO:0035176] GO:0001992; GO:0004990; GO:0005000; GO:0005887; GO:0007565; GO:0007595; GO:0032870; GO:0035176; GO:0042277; GO:0042711; GO:0045777; GO:0045907; GO:1901652 0 0 0 PF00001; P57756 CHOYP_FGL2.2.9 m.21919 sp FCN2_RAT 48.485 198 98 4 91 287 123 317 1.12E-50 172 FCN2_RAT reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Rattus norvegicus (Rat) 319 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0033691; GO:0046872 0 0 0 PF01391;PF00147; P58308 CHOYP_BRS4.1.1 m.38558 sp OX2R_MOUSE 23.834 386 238 16 27 396 51 396 1.12E-09 63.5 OX2R_MOUSE reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P62972 CHOYP_CAOG_00296.1.1 m.56129 sp UBIQP_XENLA 30.345 145 101 0 4 148 14 158 1.12E-14 75.1 UBIQP_XENLA reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Xenopus laevis (African clawed frog) 167 0 GO:0005634; GO:0005737 0 0 0 PF00240; P86733 CHOYP_LOC100725729.4.5 m.50643 sp KCP_HALAI 52.564 78 35 2 81 158 51 126 1.12E-18 80.1 KCP_HALAI reviewed BPTI/Kunitz domain-containing protein (Fragment) 0 Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) 126 0 GO:0004867; GO:0005576 0 0 0 PF00014; P94459 CHOYP_RL23.10.11 m.65117 sp PPSD_BACSU 34.615 78 46 1 23 100 1500 1572 1.12E-06 48.5 PPSD_BACSU reviewed Plipastatin synthase subunit D (EC 2.3.1.-) (Peptide synthase 4) [Includes: ATP-dependent proline adenylase (ProA 1) (Proline activase 1); ATP-dependent glutamine adenylase (GlnA) (Glutamine activase); ATP-dependent tyrosine adenylase 2 (TyrA 2) (Tyrosine activase 2)] ppsD pps4 BSU18310 Bacillus subtilis (strain 168) 3603 antibiotic biosynthetic process [GO:0017000] GO:0016740; GO:0017000; GO:0031177 0 0 0 PF00501;PF13193;PF00668;PF00550; Q0IH24 CHOYP_SPEF1.4.4 m.29121 sp SPEF1_XENLA 45.868 242 108 6 12 248 3 226 1.12E-56 184 SPEF1_XENLA reviewed Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) 229 0 GO:0005737; GO:0005930 0 0 0 PF06294; Q12955 CHOYP_LOC578974.8.11 m.45921 sp ANK3_HUMAN 32.415 472 291 2 24 467 61 532 1.12E-73 256 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q14BI2 CHOYP_BTKL.1.1 m.55270 sp GRM2_MOUSE 31.027 477 292 10 1479 1941 28 481 1.12E-56 218 GRM2_MOUSE reviewed Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 Mus musculus (Mouse) 872 "glutamate secretion [GO:0014047]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0001641; GO:0005246; GO:0005622; GO:0005887; GO:0014047; GO:0030054; GO:0030424; GO:0030425; GO:0042734; GO:0043005; GO:0051966 0 0 0 PF00003;PF01094;PF07562; Q14D04 CHOYP_LOC100167479.1.1 m.54285 sp MELT_HUMAN 34.909 825 453 11 1 745 1 821 1.12E-158 484 MELT_HUMAN reviewed Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted) VEPH1 KIAA1692 VEPH Homo sapiens (Human) 833 0 GO:0005886 0 0 0 PF00169; Q3UCV8 CHOYP_LOC100177299.1.2 m.41828 sp OTUL_MOUSE 39.858 281 164 4 643 923 69 344 1.12E-61 216 OTUL_MOUSE reviewed Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) Otulin Fam105b Gum Mus musculus (Mouse) 352 canonical Wnt signaling pathway [GO:0060070]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; protein linear deubiquitination [GO:1990108]; sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004843; GO:0005737; GO:0008234; GO:0032088; GO:0045087; GO:0050728; GO:0060070; GO:0070431; GO:1990108 0 0 0 PF16218; Q4UMH6 CHOYP_LOC752844.3.4 m.13830 sp Y381_RICFE 37 200 118 3 27 226 655 846 1.12E-27 117 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q4ZJM9 CHOYP_C1QL2.15.32 m.22816 sp C1QL4_MOUSE 34.109 129 74 5 53 175 110 233 1.12E-08 56.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q502M6 CHOYP_TVAG_033450.3.4 m.61128 sp ANR29_DANRE 40.876 137 81 0 8 144 63 199 1.12E-27 106 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5EAC7 CHOYP_DRE2.2.2 m.41479 sp CPIN1_BOVIN 49.351 308 146 7 6 305 3 308 1.12E-97 293 CPIN1_BOVIN reviewed Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) CIAPIN1 Bos taurus (Bovine) 310 apoptotic process [GO:0006915]; hemopoiesis [GO:0030097]; iron-sulfur cluster assembly [GO:0016226]; negative regulation of apoptotic process [GO:0043066] GO:0005654; GO:0005730; GO:0005737; GO:0005758; GO:0006915; GO:0009055; GO:0016226; GO:0030097; GO:0043066; GO:0046872; GO:0051537 0 0 0 PF05093; Q5NVR2 CHOYP_MDHM.1.1 m.43603 sp MDHM_PONAB 65.269 334 112 2 29 362 5 334 1.12E-158 451 MDHM_PONAB reviewed "Malate dehydrogenase, mitochondrial (EC 1.1.1.37)" MDH2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 338 carbohydrate metabolic process [GO:0005975]; internal protein amino acid acetylation [GO:0006475]; malate metabolic process [GO:0006108]; tricarboxylic acid cycle [GO:0006099] GO:0005759; GO:0005975; GO:0006099; GO:0006108; GO:0006475; GO:0030060 0 0 0 PF02866;PF00056; Q5R5L7 CHOYP_AGAP_AGAP001892.1.1 m.29422 sp ARRD3_PONAB 31.165 369 226 10 2 348 5 367 1.12E-43 160 ARRD3_PONAB reviewed Arrestin domain-containing protein 3 ARRDC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 414 0 GO:0005764; GO:0005769; GO:0005886 0 0 0 PF02752;PF00339; Q5T6F2 CHOYP_UBAP2.1.1 m.26260 sp UBAP2_HUMAN 47.222 72 32 2 40 106 1026 1096 1.12E-08 54.3 UBAP2_HUMAN reviewed Ubiquitin-associated protein 2 (UBAP-2) UBAP2 KIAA1491 Homo sapiens (Human) 1119 0 GO:0005913; GO:0044822; GO:0098641 0 0 0 PF12478; Q5TZA2 CHOYP_contig_016493 m.19419 sp CROCC_HUMAN 57.727 220 89 2 76 295 38 253 1.12E-66 229 CROCC_HUMAN reviewed Rootletin (Ciliary rootlet coiled-coil protein) CROCC KIAA0445 Homo sapiens (Human) 2017 cell cycle [GO:0007049]; centriole-centriole cohesion [GO:0010457]; centrosome organization [GO:0051297]; ciliary basal body organization [GO:0032053]; epithelial structure maintenance [GO:0010669]; establishment of organelle localization [GO:0051656]; photoreceptor cell maintenance [GO:0045494]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365] GO:0001917; GO:0005198; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0007049; GO:0008104; GO:0010457; GO:0010669; GO:0015629; GO:0019894; GO:0032053; GO:0033365; GO:0035253; GO:0045494; GO:0051297; GO:0051656; GO:0070062 0 0 0 0 Q5ZIJ0 CHOYP_NEMVEDRAFT_V1G165724.1.1 m.29952 sp BUD13_CHICK 41.414 396 150 15 104 433 180 559 1.12E-57 201 BUD13_CHICK reviewed BUD13 homolog BUD13 RCJMB04_25m15 Gallus gallus (Chicken) 559 0 0 0 0 0 PF09736; Q6N075 CHOYP_LOC100181613.1.1 m.62539 sp MFSD5_HUMAN 31.529 425 262 8 60 464 34 449 1.12E-60 208 MFSD5_HUMAN reviewed Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) MFSD5 UNQ832/PRO1759 Homo sapiens (Human) 450 0 GO:0005886; GO:0015098; GO:0016020; GO:0016021 0 0 0 PF05631; Q6NT55 CHOYP_BRAFLDRAFT_225290.1.1 m.5737 sp CP4FN_HUMAN 44.093 474 249 7 34 499 59 524 1.12E-126 382 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q6PEE2 CHOYP_LOC100726220.1.1 m.8701 sp CTIF_MOUSE 33.476 233 152 2 72 301 368 600 1.12E-40 152 CTIF_MOUSE reviewed CBP80/20-dependent translation initiation factor Ctif Gm672 Kiaa0427 Mus musculus (Mouse) 600 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational initiation [GO:0006446]" GO:0000184; GO:0003723; GO:0005737; GO:0006446; GO:0048471 0 0 0 PF02854; Q6UUV9 CHOYP_LOC100378719.1.1 m.7367 sp CRTC1_HUMAN 34.478 728 324 32 4 678 6 633 1.12E-72 250 CRTC1_HUMAN reviewed CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) CRTC1 KIAA0616 MECT1 TORC1 WAMTP1 Homo sapiens (Human) 634 "entrainment of circadian clock by photoperiod [GO:0043153]; membrane hyperpolarization [GO:0060081]; memory [GO:0007613]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendrite development [GO:1900006]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein homotetramerization [GO:0051289]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0006351; GO:0007613; GO:0008140; GO:0016032; GO:0030425; GO:0032793; GO:0043025; GO:0043153; GO:0045202; GO:0045944; GO:0048511; GO:0051289; GO:0060081; GO:1900006; GO:1900273 0 0 0 PF12886;PF12885;PF12884; Q6ZRF8 CHOYP_BRAFLDRAFT_123268.4.4 m.53327 sp RN207_HUMAN 22.222 207 146 7 17 221 103 296 1.12E-09 63.5 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7JUX9 CHOYP_TRMT10C.1.1 m.28292 sp MRRP1_DROME 30.634 284 169 9 93 358 97 370 1.12E-23 104 MRRP1_DROME reviewed Mitochondrial ribonuclease P protein 1 homolog (Mitochondrial RNase P protein 1) (EC 2.1.1.-) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (tRNA methyltransferase 10 homolog C) trmt10c CG5190 Drosophila melanogaster (Fruit fly) 446 tRNA processing [GO:0008033] GO:0005739; GO:0008033; GO:0008168 0 0 0 PF01746; Q7M456 CHOYP_DYAK_GE21648.1.1 m.44524 sp RNOY_CRAGI 37.805 82 44 4 16 91 25 105 1.12E-11 61.2 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q7ZUB2 CHOYP_BRAFLDRAFT_113849.1.1 m.53400 sp RS17_COTJA 82.09 134 22 2 10 143 1 132 1.12E-74 221 RS17_COTJA reviewed 40S ribosomal protein S17 RPS17 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 135 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00833; Q801S8 CHOYP_COHA1.1.1 m.60326 sp CO6A1_XENLA 40.726 248 116 4 89 316 323 559 1.12E-27 119 CO6A1_XENLA reviewed Collagen alpha-1(VI) chain col6a1 Xenopus laevis (African clawed frog) 1045 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; Q80U56 CHOYP_LOC591009.1.1 m.54070 sp AVL9_MOUSE 57.322 239 102 0 4 242 8 246 1.12E-93 311 AVL9_MOUSE reviewed Late secretory pathway protein AVL9 homolog Avl9 Kiaa0241 Mus musculus (Mouse) 649 cell migration [GO:0016477] GO:0016021; GO:0016477; GO:0055037 0 0 0 PF09794; Q80YD6 CHOYP_SRGEF.1.1 m.17341 sp SRGEF_MOUSE 39.268 410 194 15 5 382 17 403 1.12E-74 242 SRGEF_MOUSE reviewed Secretion-regulating guanine nucleotide exchange factor (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF) (Guanine nucleotide exchange factor-related protein) Sergef Delgef Gnefr Mus musculus (Mouse) 464 negative regulation of protein secretion [GO:0050709] GO:0005087; GO:0005634; GO:0005737; GO:0050709 0 0 0 PF00415; Q8AXF4 CHOYP_FBXO43.1.1 m.11511 sp FBX43_XENLA 29.091 220 139 6 198 404 436 651 1.12E-21 100 FBX43_XENLA reviewed F-box only protein 43 (Early mitotic inhibitor 2) (Emi1-related protein 1) (F-box protein 26) (Xerp1) fbxo43 emi2 erp1 fbx26 Xenopus laevis (African clawed frog) 651 meiotic cell cycle [GO:0051321]; protein ubiquitination [GO:0016567] GO:0016567; GO:0046872; GO:0051321 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00646;PF01485; Q8I7P9 CHOYP_LOC100894010.3.6 m.11320 sp POL5_DROME 33.05 823 475 24 259 1042 88 873 1.12E-115 390 POL5_DROME reviewed Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1003 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003676; GO:0003964; GO:0004519; GO:0005634; GO:0006313; GO:0008233; GO:0015074 0 0 0 PF00665;PF00078; Q8IW92 CHOYP_GLBL2.2.2 m.25741 sp GLBL2_HUMAN 41.27 126 73 1 25 150 502 626 1.12E-29 116 GLBL2_HUMAN reviewed Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) GLB1L2 MSTP014 UNQ210/PRO236 Homo sapiens (Human) 636 carbohydrate metabolic process [GO:0005975] GO:0004565; GO:0005576; GO:0005773; GO:0005975 0 0 0 PF01301; Q8K0U4 CHOYP_BRAFLDRAFT_208293.13.20 m.56016 sp HS12A_MOUSE 33.128 649 346 18 16 606 56 674 1.12E-96 313 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8NDA2 CHOYP_BRAFLDRAFT_83400.1.2 m.18852 sp HMCN2_HUMAN 30.435 207 122 9 125 330 4206 4391 1.12E-12 72.8 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8NHR9 CHOYP_PROF4.1.1 m.9180 sp PROF4_HUMAN 33.333 96 62 2 70 164 34 128 1.12E-08 53.9 PROF4_HUMAN reviewed Profilin-4 (Profilin IV) PFN4 Homo sapiens (Human) 129 sequestering of actin monomers [GO:0042989] GO:0003785; GO:0005938; GO:0008289; GO:0015629; GO:0042989 0 0 0 PF00235; Q8WZ42 CHOYP_DWIL_GK20677.2.2 m.39087 sp TITIN_HUMAN 25.388 516 322 21 59 535 8897 9388 1.12E-21 105 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q91W67 CHOYP_LOC100371503.1.1 m.62767 sp UBL7_MOUSE 34.783 345 164 11 45 333 39 378 1.12E-40 149 UBL7_MOUSE reviewed Ubiquitin-like protein 7 Ubl7 Mus musculus (Mouse) 380 0 0 0 0 0 PF00627;PF00240; Q91WQ9 CHOYP_AAEL_AAEL011979.1.1 m.59057 sp CALL4_MOUSE 39.61 154 88 3 16 165 1 153 1.12E-36 127 CALL4_MOUSE reviewed Calmodulin-like protein 4 (Calmodulin-related) (CALM-Rel) Calml4 Mus musculus (Mouse) 153 0 GO:0005509 0 0 0 PF13499;PF13833; Q92193 CHOYP_PAN2.1.1 m.44693 sp ACT_CRAVI 94.068 118 7 0 11 128 7 124 1.12E-75 228 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9BYK8 CHOYP_LOC100368178.2.3 m.39519 sp HELZ2_HUMAN 28.689 1708 989 50 258 1902 1083 2624 1.12E-173 592 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9CQH8 CHOYP_RPP14.2.2 m.14622 sp RPP14_MOUSE 39 100 59 2 15 113 19 117 1.12E-14 68.2 RPP14_MOUSE reviewed Ribonuclease P protein subunit p14 (EC 3.1.26.5) Rpp14 Mus musculus (Mouse) 122 tRNA processing [GO:0008033] GO:0004526; GO:0005730; GO:0005737; GO:0005739; GO:0008033 0 0 0 PF01900; Q9D032 CHOYP_LOC662190.2.3 m.6524 sp SSBP3_MOUSE 58.247 388 110 18 10 372 1 361 1.12E-88 277 SSBP3_MOUSE reviewed Single-stranded DNA-binding protein 3 (Lck-associated signal transducer) (Sequence-specific single-stranded-DNA-binding protein) Ssbp3 Last Ssdp1 Mus musculus (Mouse) 388 "head development [GO:0060322]; head morphogenesis [GO:0060323]; hematopoietic progenitor cell differentiation [GO:0002244]; midbrain-hindbrain boundary initiation [GO:0021547]; positive regulation of anterior head development [GO:2000744]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; prechordal plate formation [GO:0021501]; protein complex assembly [GO:0006461]; transcription, DNA-templated [GO:0006351]" GO:0002244; GO:0003697; GO:0005634; GO:0006351; GO:0006461; GO:0008284; GO:0021501; GO:0021547; GO:0043234; GO:0045893; GO:0045944; GO:0060322; GO:0060323; GO:2000744 0 0 0 0 Q9D3D9 CHOYP_LOC101072646.1.1 m.8800 sp ATPD_MOUSE 50.382 131 65 0 38 168 38 168 1.12E-38 132 ATPD_MOUSE reviewed "ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)" Atp5d Mus musculus (Mouse) 168 ATP synthesis coupled proton transport [GO:0015986]; proton transport [GO:0015992] GO:0000275; GO:0005739; GO:0005740; GO:0005743; GO:0005753; GO:0015078; GO:0015986; GO:0015992; GO:0045259; GO:0046933; GO:0046961 0 0 cd12152; PF02823; Q9H204 CHOYP_MED28.2.2 m.50353 sp MED28_HUMAN 51.923 104 50 0 20 123 44 147 1.12E-31 117 MED28_HUMAN reviewed Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1) MED28 EG1 FKSG20 Homo sapiens (Human) 178 "negative regulation of smooth muscle cell differentiation [GO:0051151]; regulation of transcription, DNA-templated [GO:0006355]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0016020; GO:0016592; GO:0019827; GO:0030864; GO:0051151 0 0 0 PF11594; Q9H7B4 CHOYP_DMOJ_GI16066.1.1 m.48211 sp SMYD3_HUMAN 35.321 436 224 7 5 433 24 408 1.12E-78 254 SMYD3_HUMAN reviewed Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.43) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1) SMYD3 ZMYND1 ZNFN3A1 Homo sapiens (Human) 428 cellular response to dexamethasone stimulus [GO:0071549]; establishment of protein localization [GO:0045184]; myotube cell development [GO:0014904]; negative regulation of protein kinase activity [GO:0006469]; nucleosome assembly [GO:0006334]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000979; GO:0001162; GO:0005654; GO:0005737; GO:0006334; GO:0006469; GO:0014904; GO:0018024; GO:0033138; GO:0045184; GO:0045944; GO:0046872; GO:0071549 0 0 0 PF00856;PF01753; Q9JI18 CHOYP_BRAFLDRAFT_120630.1.1 m.2111 sp LRP1B_MOUSE 43.056 72 41 0 28 99 891 962 1.12E-10 60.1 LRP1B_MOUSE reviewed Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) 4599 in utero embryonic development [GO:0001701] GO:0001701; GO:0005041; GO:0005509; GO:0016020; GO:0016021; GO:0043235; GO:0050750 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q9NRP7 CHOYP_STK36.1.1 m.12874 sp STK36_HUMAN 55.644 505 184 9 1 492 1 478 1.12E-178 540 STK36_HUMAN reviewed Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) STK36 KIAA1278 Homo sapiens (Human) 1315 brain development [GO:0007420]; cilium assembly [GO:0042384]; epithelial cilium movement [GO:0003351]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090] GO:0000287; GO:0003351; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007228; GO:0007420; GO:0008134; GO:0009791; GO:0042384; GO:0045880; GO:0051090 0 0 0 PF00069; Q9QUN3 CHOYP_PHUM_PHUM128460.7.7 m.66995 sp BLNK_MOUSE 34.513 113 70 3 470 579 342 453 1.12E-14 80.1 BLNK_MOUSE reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) Blnk Bash Ly57 Slp65 Mus musculus (Mouse) 457 B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005737; GO:0005886; GO:0006955; GO:0035556; GO:0042113 0 0 0 PF00017; Q9TU53 CHOYP_BRAFLDRAFT_143777.2.2 m.64068 sp CUBN_CANLF 27.767 515 305 20 51 554 1990 2448 1.12E-38 158 CUBN_CANLF reviewed Cubilin CUBN Canis lupus familiaris (Dog) (Canis familiaris) 3620 cholesterol metabolic process [GO:0008203]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0005509; GO:0005765; GO:0006898; GO:0008203; GO:0010008; GO:0015031; GO:0016324; GO:0031419 0 0 0 PF00431;PF00008;PF12947;PF07645; Q9UGM3 CHOYP_DMBT1.24.34 m.47540 sp DMBT1_HUMAN 41.486 552 240 11 3 480 572 1114 1.12E-106 374 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9V4M2 CHOYP_GSU3225.1.1 m.23984 sp WECH_DROME 36.585 82 48 2 40 118 544 624 1.12E-07 53.1 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; Q9VXX8 CHOYP_LOC100533258.4.6 m.29112 sp RL371_DROME 75 88 22 0 20 107 1 88 1.12E-42 138 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9WU00 CHOYP_CPIPJ_CPIJ009997.1.1 m.43172 sp NRF1_MOUSE 41.905 105 44 4 9 100 179 279 1.12E-14 80.9 NRF1_MOUSE reviewed Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) Nrf1 Mus musculus (Mouse) 503 mitochondrion organization [GO:0007005]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001046; GO:0001077; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0007005; GO:0042803; GO:0045944; GO:0070062 0 0 0 PF10492;PF10491; A0MSJ1 CHOYP_contig_019571 m.22867 sp CRA1B_DANRE 41.905 210 97 2 75 259 972 1181 1.13E-23 106 CRA1B_DANRE reviewed Collagen alpha-1(XXVII) chain B col27a1b col27a1 Danio rerio (Zebrafish) (Brachydanio rerio) 1658 bone mineralization [GO:0030282]; notochord morphogenesis [GO:0048570]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005578; GO:0005581; GO:0030282; GO:0046872; GO:0048570 0 0 0 PF01410;PF01391; A2AVA0 CHOYP_SELP.1.1 m.33900 sp SVEP1_MOUSE 30.688 189 117 9 3 184 1885 2066 1.13E-16 84 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A3RLT6 CHOYP_LOC100543980.1.2 m.728 sp RSSA_PINFU 92.623 122 9 0 1 122 1 122 1.13E-69 214 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A4IF63 CHOYP_contig_041055 m.46758 sp TRIM2_BOVIN 24.309 181 110 6 192 361 492 656 1.13E-06 54.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A9UMG5 CHOYP_IMPACT.1.1 m.38643 sp IMPTB_XENTR 49.175 303 142 5 4 305 9 300 1.13E-94 286 IMPTB_XENTR reviewed Protein IMPACT-B (Imprinted and ancient gene protein homolog B) impact-B Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 317 cellular response to acidic pH [GO:0071468]; cellular response to amino acid starvation [GO:0034198]; cellular response to benomyl [GO:0072755]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to leucine starvation [GO:1990253]; cellular response to UV-C [GO:0071494]; negative regulation of cell death [GO:0060548]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein complex assembly [GO:0031333]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to stress [GO:0097201]; neuron projection extension [GO:1990138]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of translational initiation in response to starvation [GO:0071264]; regulation of eIF2 alpha phosphorylation by amino acid starvation [GO:0060733] GO:0000122; GO:0001933; GO:0005737; GO:0005844; GO:0031333; GO:0031953; GO:0034198; GO:0042149; GO:0045666; GO:0060548; GO:0060733; GO:0070301; GO:0071264; GO:0071468; GO:0071494; GO:0072755; GO:0097201; GO:1990138; GO:1990253 0 0 0 PF05773;PF01205; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.5.15 m.16483 sp MLRP2_ACRMI 30.521 1304 710 53 1 1234 539 1716 1.13E-123 427 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3STU3 CHOYP_CHAC1.3.3 m.37783 sp CHAC1_RAT 45.455 176 86 4 2 175 31 198 1.13E-47 163 CHAC1_RAT reviewed Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 2.3.2.-) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1) (Neuroprotective protein 7) Chac1 Botch Npg7 Rattus norvegicus (Rat) 222 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein processing [GO:0010955]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; response to unfolded protein [GO:0006986] GO:0005112; GO:0005802; GO:0005829; GO:0006986; GO:0007219; GO:0010955; GO:0016746; GO:0022008; GO:0045746; GO:0070059 0 0 cd06661; PF04752; B4QLQ2 CHOYP_KLHDB.2.5 m.45070 sp KLHDB_DROSI 25.443 621 390 14 379 975 20 591 1.13E-40 163 KLHDB_DROSI reviewed Kelch-like protein diablo dbo GD14575 Drosophila simulans (Fruit fly) 623 cell growth [GO:0016049]; protein ubiquitination [GO:0016567]; regulation of synapse organization [GO:0050807] GO:0016049; GO:0016567; GO:0050807 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9Y2M5}. 0 0 PF07707;PF00651;PF01344; D2GXS7 CHOYP_BRAFLDRAFT_87319.3.5 m.38290 sp TRIM2_AILME 25.654 191 117 7 2 181 516 692 1.13E-06 51.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2H5P6 CHOYP_ZFY26.2.2 m.35344 sp ZFY26_AILME 30.508 236 141 7 146 373 1513 1733 1.13E-15 83.6 ZFY26_AILME reviewed Zinc finger FYVE domain-containing protein 26 ZFYVE26 PANDA_005234 Ailuropoda melanoleuca (Giant panda) 2543 cytokinesis [GO:0000910]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0000910; GO:0005737; GO:0005813; GO:0030496; GO:0032266; GO:0046872 0 0 0 PF01363; O01814 CHOYP_TSP_02835.1.1 m.26375 sp FABP5_CAEEL 29.457 129 90 1 7 134 5 133 1.13E-13 66.6 FABP5_CAEEL reviewed Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans 136 0 GO:0005215; GO:0005504; GO:0005634; GO:0048471 0 0 0 PF00061; O15072 CHOYP_ATS20.2.2 m.52571 sp ATS3_HUMAN 31.316 1041 608 28 19 979 2 1015 1.13E-157 512 ATS3_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) ADAMTS3 KIAA0366 Homo sapiens (Human) 1205 collagen biosynthetic process [GO:0032964]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular fibril organization [GO:0043206]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein processing [GO:0016485]; vascular endothelial growth factor production [GO:0010573] GO:0004175; GO:0004222; GO:0005576; GO:0005578; GO:0005615; GO:0008201; GO:0008270; GO:0010573; GO:0016485; GO:0030199; GO:0030574; GO:0032964; GO:0043206; GO:0070062; GO:1900748 0 0 0 PF05986;PF01562;PF01421;PF00090; O35930 CHOYP_contig_014364 m.16441 sp GP1BA_MOUSE 46.111 180 72 10 2 165 358 528 1.13E-06 55.8 GP1BA_MOUSE reviewed Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (CD antigen CD42b) Gp1ba Mus musculus (Mouse) 734 blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cytokine-mediated signaling pathway [GO:0019221]; fibrinolysis [GO:0042730]; hemostasis [GO:0007599]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469] GO:0000902; GO:0004860; GO:0005737; GO:0005886; GO:0005887; GO:0006469; GO:0007155; GO:0007596; GO:0007599; GO:0009986; GO:0016020; GO:0019221; GO:0031362; GO:0042730; GO:0046426; GO:0070062 0 0 0 PF13855; O70277 CHOYP_BRAFLDRAFT_87268.1.4 m.32573 sp TRIM3_RAT 23.214 224 157 5 177 388 488 708 1.13E-08 60.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_LOC593853.1.4 m.24273 sp ANR17_HUMAN 32.157 255 136 6 10 227 403 657 1.13E-27 115 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_LOC100367817.5.7 m.50038 sp TRIM3_HUMAN 27.35 117 80 2 77 193 114 225 1.13E-09 64.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02637 CHOYP_SCP.4.12 m.45065 sp SCP_MIZYE 52.273 176 81 3 41 216 2 174 1.13E-60 191 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P07439 CHOYP_LOC100486681.2.2 m.63902 sp LEC3_MEGRO 33.071 127 80 3 109 231 26 151 1.13E-16 77.8 LEC3_MEGRO reviewed Lectin BRA-3 0 Megabalanus rosa (Acorn barnacle) 162 0 GO:0030246 0 0 0 PF00059; P08472 CHOYP_BRAFLDRAFT_83096.1.1 m.27011 sp M130_STRPU 26.645 304 209 6 243 534 415 716 1.13E-22 106 M130_STRPU reviewed Mesenchyme-specific cell surface glycoprotein (MSP130) 0 Strongylocentrotus purpuratus (Purple sea urchin) 779 0 GO:0005886; GO:0031225 0 0 0 0 P10079 CHOYP_LOC100634060.11.37 m.26196 sp FBP1_STRPU 57.547 106 45 0 1 106 334 439 1.13E-34 130 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P12815 CHOYP_BRAFLDRAFT_280861.1.2 m.5389 sp PDCD6_MOUSE 72.455 167 46 0 2 168 24 190 1.13E-89 263 PDCD6_MOUSE reviewed Programmed cell death protein 6 (ALG-257) (PMP41) (Probable calcium-binding protein ALG-2) Pdcd6 Alg2 Mus musculus (Mouse) 191 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324] GO:0001525; GO:0001938; GO:0004198; GO:0005509; GO:0005634; GO:0005737; GO:0005768; GO:0005783; GO:0005789; GO:0006886; GO:0006915; GO:0006919; GO:0010595; GO:0030948; GO:0031410; GO:0031965; GO:0032007; GO:0034605; GO:0036324; GO:0042802; GO:0042803; GO:0043280; GO:0043495; GO:0045766; GO:0046983; GO:0048306; GO:0051592; GO:0051898; GO:0060090; GO:0070062; GO:0070971 0 0 0 PF13202;PF13499; P24014 CHOYP_LRC15.3.3 m.44226 sp SLIT_DROME 35.398 113 70 1 2 114 198 307 1.13E-12 70.1 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P28799 CHOYP_LOC100366380.3.4 m.25320 sp GRN_HUMAN 39.529 425 227 12 20 440 113 511 1.13E-84 274 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P30151 CHOYP_EF1B.1.7 m.26504 sp EF1B_XENLA 66.816 223 67 2 55 270 1 223 1.13E-99 293 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P38542 CHOYP_RAN.3.3 m.59028 sp RAN_BRUMA 86.792 212 28 0 2 213 4 215 1.13E-140 394 RAN_BRUMA reviewed GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Bm1_44725 Brugia malayi (Filarial nematode worm) 215 intracellular protein transport [GO:0006886]; nucleocytoplasmic transport [GO:0006913]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0006886; GO:0006913; GO:0007264 0 0 0 PF00071; P41236 CHOYP_SET.1.1 m.53577 sp IPP2_HUMAN 43.902 164 79 4 2 157 3 161 1.13E-30 114 IPP2_HUMAN reviewed Protein phosphatase inhibitor 2 (IPP-2) PPP1R2 IPP2 Homo sapiens (Human) 205 generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of signal transduction [GO:0009966] GO:0000164; GO:0004865; GO:0005977; GO:0006091; GO:0009966; GO:0043666 0 0 0 PF04979; P49165 CHOYP_RL4.5.6 m.49216 sp RL4_URECA 73.723 137 35 1 1 137 195 330 1.13E-66 209 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; P49713 CHOYP_LOC592142.2.9 m.27989 sp FUCO_CAEEL 52.5 80 38 0 36 115 18 97 1.13E-25 102 FUCO_CAEEL reviewed Putative alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) W03G11.3 Caenorhabditis elegans 482 fucose metabolic process [GO:0006004] GO:0004560; GO:0006004 0 0 0 PF01120; P49900 CHOYP_ARGI.1.2 m.3263 sp ARGI_LITCT 54.921 315 140 2 7 320 7 320 1.13E-119 350 ARGI_LITCT reviewed "Arginase, hepatic (EC 3.5.3.1)" 0 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 323 arginine metabolic process [GO:0006525]; urea cycle [GO:0000050] GO:0000050; GO:0004053; GO:0006525; GO:0046872 PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000250|UniProtKB:P05089}. 0 0 PF00491; P97357 CHOYP_TAF1A.1.1 m.16831 sp TAF1A_MOUSE 28.194 227 155 3 95 319 90 310 1.13E-18 89.4 TAF1A_MOUSE reviewed TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription initiation factor SL1/TIF-IB subunit A) Taf1a Mus musculus (Mouse) 453 chromatin silencing at rDNA [GO:0000183]; transcription from RNA polymerase I promoter [GO:0006360]; transcription initiation from RNA polymerase I promoter [GO:0006361] GO:0000120; GO:0000183; GO:0003677; GO:0005634; GO:0005654; GO:0006360; GO:0006361; GO:0015630; GO:0043231 0 0 0 0 Q02645 CHOYP_ADD.4.5 m.47340 sp HTS_DROME 46.014 439 198 7 1 412 176 602 1.13E-126 401 HTS_DROME reviewed Protein hu-li tai shao (Adducin-like protein) hts CG9325 Drosophila melanogaster (Fruit fly) 1156 "actin filament bundle organization [GO:0061572]; adult somatic muscle development [GO:0007527]; axon guidance [GO:0007411]; centrosome organization [GO:0051297]; cystoblast division [GO:0007282]; female germ-line cyst formation [GO:0048135]; female germline ring canal formation, actin assembly [GO:0008302]; fusome organization [GO:0045478]; germarium-derived oocyte fate determination [GO:0007294]; germ-line cyst formation [GO:0048134]; locomotion involved in locomotory behavior [GO:0031987]; meiotic spindle organization [GO:0000212]; neuron cellular homeostasis [GO:0070050]; oogenesis [GO:0048477]; ovarian fusome organization [GO:0030723]; photoreceptor cell axon guidance [GO:0072499]; sarcomere organization [GO:0045214]; spectrosome organization [GO:0030721]; testicular fusome organization [GO:0030724]" GO:0000212; GO:0005737; GO:0005811; GO:0005856; GO:0005886; GO:0007282; GO:0007294; GO:0007411; GO:0007527; GO:0008302; GO:0016328; GO:0030721; GO:0030723; GO:0030724; GO:0031987; GO:0035183; GO:0045169; GO:0045170; GO:0045172; GO:0045214; GO:0045478; GO:0048134; GO:0048135; GO:0048477; GO:0051297; GO:0061572; GO:0070050; GO:0072499 0 0 0 PF00596; Q0Q028 CHOYP_LOC100168620.4.4 m.40081 sp DFP3_ANTMY 27.841 176 104 7 6 180 1 154 1.13E-12 67 DFP3_ANTMY reviewed Putative defense protein 3 (DFP-3) 0 Antheraea mylitta (Tasar silkworm) 163 defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087] GO:0005576; GO:0042742; GO:0042832; GO:0045087 0 0 cd08544; PF02014; Q14676 CHOYP_LOC100489926.2.3 m.7927 sp MDC1_HUMAN 43.415 205 114 1 1546 1748 1877 2081 1.13E-53 212 MDC1_HUMAN reviewed Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) MDC1 KIAA0170 NFBD1 Homo sapiens (Human) 2089 double-strand break repair via nonhomologous end joining [GO:0006303]; intra-S DNA damage checkpoint [GO:0031573]; protein sumoylation [GO:0016925] GO:0005634; GO:0005654; GO:0005694; GO:0005925; GO:0006303; GO:0008022; GO:0016925; GO:0031573; GO:0070975 0 0 0 PF00498;PF16770; Q17QD6 CHOYP_TEFF2.1.1 m.26857 sp TEFF2_BOVIN 30.769 117 71 3 41 149 103 217 1.13E-07 53.1 TEFF2_BOVIN reviewed Tomoregulin-2 (TR-2) (Transmembrane protein with EGF-like and two follistatin-like domains) TMEFF2 Bos taurus (Bovine) 374 0 GO:0016021 0 0 0 PF07648; Q2KHW8 CHOYP_BRAFLDRAFT_60087.1.1 m.23518 sp GEMI6_BOVIN 40.909 154 89 2 15 167 7 159 1.13E-34 122 GEMI6_BOVIN reviewed Gem-associated protein 6 (Gemin-6) GEMIN6 Bos taurus (Bovine) 166 spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] GO:0000245; GO:0000387; GO:0005829; GO:0032797; GO:0034719; GO:0097504 0 0 0 PF06372; Q2KHW8 CHOYP_RA54B.1.1 m.9069 sp GEMI6_BOVIN 40.909 154 89 2 15 167 7 159 1.13E-34 122 GEMI6_BOVIN reviewed Gem-associated protein 6 (Gemin-6) GEMIN6 Bos taurus (Bovine) 166 spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] GO:0000245; GO:0000387; GO:0005829; GO:0032797; GO:0034719; GO:0097504 0 0 0 PF06372; Q2LAM0 CHOYP_BRAFLDRAFT_65126.1.1 m.39620 sp FA2H_RAT 37.766 376 212 4 4 378 11 365 1.13E-91 282 FA2H_RAT reviewed Fatty acid 2-hydroxylase (EC 1.-.-.-) (Fatty acid alpha-hydroxylase) Fa2h Faah Rattus norvegicus (Rat) 372 central nervous system myelin maintenance [GO:0032286]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; lipid modification [GO:0030258]; peripheral nervous system myelin maintenance [GO:0032287]; regulation of cell proliferation [GO:0042127]; regulation of hair cycle [GO:0042634]; sebaceous gland cell differentiation [GO:0001949] GO:0001949; GO:0005506; GO:0005783; GO:0005789; GO:0006631; GO:0006633; GO:0016021; GO:0020037; GO:0030258; GO:0031090; GO:0032286; GO:0032287; GO:0042127; GO:0042634; GO:0080132 0 0 0 PF00173;PF04116; Q32NQ8 CHOYP_RNF10.1.1 m.19224 sp RNF10_XENLA 38.333 780 381 25 34 777 41 756 1.13E-139 433 RNF10_XENLA reviewed RING finger protein 10 rnf10 Xenopus laevis (African clawed frog) 756 "negative regulation of Schwann cell proliferation [GO:0010626]; positive regulation of myelination [GO:0031643]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0008270; GO:0010626; GO:0031643; GO:0044212; GO:0045944 0 0 0 PF00097; Q3MHN8 CHOYP_TRM5.1.1 m.24347 sp TRM5_BOVIN 43.653 449 235 7 21 464 55 490 1.13E-123 372 TRM5_BOVIN reviewed tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) TRMT5 TRM5 Bos taurus (Bovine) 497 mitochondrial tRNA methylation [GO:0070901] GO:0005634; GO:0005759; GO:0052906; GO:0070901 0 0 0 PF02475; Q3UIR3 CHOYP_DTX3L.2.4 m.51200 sp DTX3L_MOUSE 55.556 180 78 2 833 1011 569 747 1.13E-59 222 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q460N5 CHOYP_BRAFLDRAFT_74874.1.9 m.3546 sp PAR14_HUMAN 47.236 199 103 2 131 329 1604 1800 1.13E-51 187 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4KM33 CHOYP_NEMVEDRAFT_V1G237545.1.1 m.34853 sp PLEK_RAT 26.829 246 160 6 5 245 47 277 1.13E-21 97.1 PLEK_RAT reviewed Pleckstrin Plek Rattus norvegicus (Rat) 350 actin cytoskeleton reorganization [GO:0031532]; cortical actin cytoskeleton organization [GO:0030866]; hematopoietic progenitor cell differentiation [GO:0002244]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-inhibiting G-protein coupled receptor signaling pathway [GO:0030845]; platelet aggregation [GO:0070527]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of inositol-polyphosphate 5-phosphatase activity [GO:0010925]; positive regulation of integrin activation [GO:0033625]; positive regulation of platelet activation [GO:0010572]; protein kinase C signaling [GO:0070528]; protein secretion by platelet [GO:0070560]; regulation of cell diameter [GO:0060305]; ruffle organization [GO:0031529]; thrombin receptor signaling pathway [GO:0070493]; vesicle docking involved in exocytosis [GO:0006904] GO:0002244; GO:0005737; GO:0006904; GO:0007229; GO:0010572; GO:0010920; GO:0010925; GO:0030836; GO:0030845; GO:0030866; GO:0031529; GO:0031532; GO:0032233; GO:0032587; GO:0033625; GO:0043325; GO:0045744; GO:0046488; GO:0060305; GO:0070493; GO:0070527; GO:0070528; GO:0070560 0 0 0 PF00610;PF00169; Q4R6F0 CHOYP_LOC100378821.1.1 m.8967 sp LRRD1_MACFA 31.333 750 502 5 42 784 120 863 1.13E-115 373 LRRD1_MACFA reviewed Leucine-rich repeat and death domain-containing protein 1 LRRD1 QtsA-18164 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 863 signal transduction [GO:0007165] GO:0007165 0 0 0 PF13855; Q502M6 CHOYP_AOR_1_1386094.4.6 m.32759 sp ANR29_DANRE 41.007 139 82 0 8 146 62 200 1.13E-28 109 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q54SZ9 CHOYP_LOC100203559.1.1 m.61767 sp Y2107_DICDI 24.793 121 84 2 78 197 26 140 1.13E-06 49.7 Y2107_DICDI reviewed Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282107 DDB_G0282107 Dictyostelium discoideum (Slime mold) 147 lipid transport [GO:0006869] GO:0006869 0 0 0 PF02221; Q56JY1 CHOYP_LOC100214200.1.1 m.20420 sp RL35A_BOVIN 65.741 108 36 1 6 113 4 110 1.13E-45 146 RL35A_BOVIN reviewed 60S ribosomal protein L35a RPL35A Bos taurus (Bovine) 110 cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273] GO:0000049; GO:0002181; GO:0003735; GO:0022625; GO:0042273 0 0 0 PF01247; Q58D34 CHOYP_CRSPL.1.1 m.40174 sp PI16_BOVIN 42.604 169 81 6 25 184 36 197 1.13E-34 130 PI16_BOVIN reviewed Peptidase inhibitor 16 (PI-16) PI16 Bos taurus (Bovine) 464 0 GO:0016021; GO:0030414; GO:0070062 0 0 0 PF00188; Q5DU00 CHOYP_DCDC2.1.7 m.31233 sp DCDC2_MOUSE 29.787 423 235 14 2 410 6 380 1.13E-33 138 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q5M9P8 CHOYP_ARL6.1.2 m.29833 sp ARL6_DANRE 72.826 184 50 0 1 184 1 184 1.13E-100 291 ARL6_DANRE reviewed ADP-ribosylation factor-like protein 6 arl6 si:dkey-24h22.2 zgc:101762 Danio rerio (Zebrafish) (Brachydanio rerio) 186 cilium assembly [GO:0042384]; determination of left/right symmetry [GO:0007368]; gastrulation [GO:0007369]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; pectoral fin development [GO:0033339]; regulation of Notch signaling pathway [GO:0008593]; small GTPase mediated signal transduction [GO:0007264]; visual perception [GO:0007601] GO:0005525; GO:0005737; GO:0005856; GO:0007264; GO:0007368; GO:0007369; GO:0007601; GO:0008593; GO:0032402; GO:0033339; GO:0042384; GO:0046872; GO:0060170; GO:0070121 0 0 0 PF00025; Q5R9R4 CHOYP_BRAFLDRAFT_125387.1.2 m.21901 sp RL7_PONAB 66.814 226 75 0 4 229 6 231 1.13E-103 310 RL7_PONAB reviewed 60S ribosomal protein L7 RPL7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 247 ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0003677; GO:0003729; GO:0005730; GO:0005925; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0070062 0 0 0 PF00327;PF08079; Q5RI56 CHOYP_LOC100376215.13.19 m.37460 sp OPTN_DANRE 29.648 199 100 5 299 497 358 516 1.13E-17 89.4 OPTN_DANRE reviewed Optineurin optn si:ch211-240l19.3 zgc:66386 zgc:77868 Danio rerio (Zebrafish) (Brachydanio rerio) 517 autophagy [GO:0006914]; axonogenesis [GO:0007409]; Golgi ribbon formation [GO:0090161]; protein targeting to Golgi [GO:0000042]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; vesicle localization [GO:0051648] GO:0000042; GO:0005634; GO:0005794; GO:0006914; GO:0007409; GO:0016023; GO:0043122; GO:0046872; GO:0051648; GO:0070530; GO:0090161 0 0 0 PF16516;PF11577; Q5T7P8 CHOYP_LOC100376714.2.3 m.40432 sp SYT6_HUMAN 37.696 191 109 6 80 265 203 388 1.13E-33 130 SYT6_HUMAN reviewed Synaptotagmin-6 (Synaptotagmin VI) (SytVI) SYT6 Homo sapiens (Human) 510 acrosomal vesicle exocytosis [GO:0060478]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle fusion [GO:0006906] GO:0005509; GO:0005829; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019898; GO:0019905; GO:0030054; GO:0030276; GO:0030672; GO:0042803; GO:0048791; GO:0060478; GO:0070382; GO:0097038 0 0 0 PF00168; Q5XIG2 CHOYP_CAPR2.3.4 m.5538 sp C1QT1_RAT 32.609 138 89 2 49 182 144 281 1.13E-14 73.6 C1QT1_RAT reviewed Complement C1q tumor necrosis factor-related protein 1 C1qtnf1 Rattus norvegicus (Rat) 281 0 GO:0005576; GO:0005581 0 0 0 PF00386;PF01391; Q62356 CHOYP_NEMVEDRAFT_V1G171044.1.1 m.44527 sp FSTL1_MOUSE 34.274 248 140 7 35 269 28 265 1.13E-30 120 FSTL1_MOUSE reviewed Follistatin-related protein 1 (Follistatin-like protein 1) (TGF-beta-inducible protein TSC-36) Fstl1 Frp Fstl Tsc36 Mus musculus (Mouse) 306 response to starvation [GO:0042594] GO:0005509; GO:0005615; GO:0008201; GO:0042594; GO:0070062 0 0 0 PF09289;PF07648; Q63447 CHOYP_contig_040292 m.45670 sp NPY4R_RAT 26.829 123 90 0 29 151 53 175 1.13E-06 53.9 NPY4R_RAT reviewed Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) Npy4r Ppyr1 Rattus norvegicus (Rat) 375 blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631] GO:0001601; GO:0001602; GO:0005887; GO:0007166; GO:0007631; GO:0008015; GO:0042277 0 0 0 PF00001; Q6P4H8 CHOYP_F173B.1.1 m.12774 sp F173B_HUMAN 45.192 208 107 1 1 201 9 216 1.13E-66 207 F173B_HUMAN reviewed Protein FAM173B FAM173B Homo sapiens (Human) 233 0 GO:0016021 0 0 0 0 Q6PFY8 CHOYP_LOC100371277.1.2 m.60189 sp TRI45_MOUSE 22.261 283 187 9 4 265 127 397 1.13E-07 57 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PFY8 CHOYP_LOC100373444.74.79 m.60871 sp TRI45_MOUSE 26.012 173 100 8 1 164 147 300 1.13E-06 53.9 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7QJM5 CHOYP_COX2.2.2 m.66873 sp RL18_ANOGA 68.382 136 42 1 1 135 53 188 1.13E-63 195 RL18_ANOGA reviewed 60S ribosomal protein L18 RpL18 AGAP007580 Anopheles gambiae (African malaria mosquito) 189 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625 0 0 0 PF17135; Q7QJM5 CHOYP_LOC100560334.1.3 m.11959 sp RL18_ANOGA 68.382 136 42 1 1 135 53 188 1.13E-63 195 RL18_ANOGA reviewed 60S ribosomal protein L18 RpL18 AGAP007580 Anopheles gambiae (African malaria mosquito) 189 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625 0 0 0 PF17135; Q7ZWP1 CHOYP_LOC658003.1.1 m.29101 sp FRMD8_XENLA 31.111 405 262 9 44 443 28 420 1.13E-59 204 FRMD8_XENLA reviewed FERM domain-containing protein 8 frmd8 Xenopus laevis (African clawed frog) 452 0 GO:0005856 0 0 0 PF00373; Q803C1 CHOYP_LOC100372947.1.1 m.16261 sp RNF8_DANRE 31.134 485 275 13 10 472 25 472 1.13E-52 191 RNF8_DANRE reviewed E3 ubiquitin-protein ligase RNF8 (EC 6.3.2.-) (RING finger protein 8) rnf8 zgc:55936 Danio rerio (Zebrafish) (Brachydanio rerio) 485 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; histone exchange [GO:0043486]; histone H2A K63-linked ubiquitination [GO:0070535]; histone H2A ubiquitination [GO:0033522]; histone H2B ubiquitination [GO:0033523]; isotype switching [GO:0045190]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; spermatid development [GO:0007286]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000781; GO:0003682; GO:0004842; GO:0005634; GO:0006302; GO:0006303; GO:0006511; GO:0006974; GO:0007286; GO:0008270; GO:0010212; GO:0016874; GO:0033522; GO:0033523; GO:0034244; GO:0035861; GO:0042393; GO:0042803; GO:0043486; GO:0045190; GO:0045739; GO:0070534; GO:0070535; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00498;PF00097; Q8BHJ9 CHOYP_LOC100374345.2.2 m.48827 sp SLU7_MOUSE 50 74 36 1 71 144 510 582 1.13E-14 73.2 SLU7_MOUSE reviewed Pre-mRNA-splicing factor SLU7 Slu7 D11Ertd730e Mus musculus (Mouse) 585 "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; mRNA 3'-splice site recognition [GO:0000389]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000380; GO:0000386; GO:0000389; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006886; GO:0008270; GO:0016020; GO:0016607; GO:0030532; GO:0030628; GO:0034605; GO:0043231; GO:0071013 0 0 0 PF11708; Q8BSY0 CHOYP_ASPH.2.2 m.48309 sp ASPH_MOUSE 51.636 428 204 3 528 954 316 741 1.13E-146 456 ASPH_MOUSE reviewed Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) Asph Bah Mus musculus (Mouse) 741 "activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; negative regulation of cell proliferation [GO:0008285]; palate development [GO:0060021]; pattern specification process [GO:0007389]; peptidyl-aspartic acid hydroxylation [GO:0042264]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; response to ATP [GO:0033198]" GO:0004597; GO:0005509; GO:0005737; GO:0005783; GO:0005886; GO:0007389; GO:0008285; GO:0010524; GO:0016021; GO:0030176; GO:0031585; GO:0031647; GO:0032237; GO:0032541; GO:0033017; GO:0033198; GO:0035108; GO:0042264; GO:0045862; GO:0045893; GO:0060021; GO:0060325; GO:0070588; GO:0071277; GO:0090316; GO:0097202; GO:1901879 0 0 0 PF05279;PF05118; Q8BXQ6 CHOYP_AMPO.1.1 m.13466 sp AMPO_MOUSE 31.925 852 455 18 12 783 11 817 1.13E-128 406 AMPO_MOUSE reviewed Aminopeptidase O (AP-O) (EC 3.4.11.-) Aopep Onpep Mus musculus (Mouse) 817 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004177; GO:0005730; GO:0005737; GO:0005886; GO:0006508; GO:0008237; GO:0008270; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF09127;PF01433; Q8BZ39 CHOYP_NPSR1.2.2 m.59047 sp NMUR2_MOUSE 24.235 392 214 14 5 377 1 328 1.13E-14 78.2 NMUR2_MOUSE reviewed Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) 395 activation of phospholipase A2 activity by calcium-mediated signaling [GO:0043006]; arachidonic acid secretion [GO:0050482]; calcium ion transport [GO:0006816]; central nervous system development [GO:0007417]; grooming behavior [GO:0007625]; inositol phosphate-mediated signaling [GO:0048016]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; reduction of food intake in response to dietary excess [GO:0002023]; response to pain [GO:0048265] GO:0001607; GO:0002023; GO:0005229; GO:0005525; GO:0005829; GO:0005886; GO:0006816; GO:0007200; GO:0007204; GO:0007218; GO:0007417; GO:0007625; GO:0008188; GO:0016021; GO:0042924; GO:0043006; GO:0048016; GO:0048265; GO:0050482 0 0 0 PF00001; Q8IN35 CHOYP_ISCW_ISCW009595.2.2 m.61447 sp SIFAR_DROME 26.603 312 186 11 45 331 217 510 1.13E-26 115 SIFAR_DROME reviewed Neuropeptide SIFamide receptor SIFaR SIFR CG10823 Drosophila melanogaster (Fruit fly) 758 "determination of adult lifespan [GO:0008340]; G-protein coupled receptor signaling pathway [GO:0007186]; mating behavior, sex discrimination [GO:0048047]; neuropeptide signaling pathway [GO:0007218]; sensory perception of pain [GO:0019233]" GO:0004930; GO:0004983; GO:0005887; GO:0007186; GO:0007218; GO:0008188; GO:0008340; GO:0008528; GO:0016021; GO:0019233; GO:0048047 0 0 0 PF00001; Q8ITC3 CHOYP_RS19.10.12 m.50361 sp RS19_ARGIR 73.737 99 25 1 38 136 47 144 1.13E-48 155 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8MSU3 CHOYP_LOC100168620.3.4 m.27018 sp FRRS1_DROME 28.346 381 249 10 337 706 229 596 1.13E-42 167 FRRS1_DROME reviewed Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) CG8399 Drosophila melanogaster (Fruit fly) 647 oxidation-reduction process [GO:0055114] GO:0000293; GO:0016021; GO:0055114 0 0 cd08544; PF03188;PF03351;PF02014; Q8NDA2 CHOYP_HMCN2.1.12 m.305 sp HMCN2_HUMAN 26.829 205 123 8 97 290 2908 3096 1.13E-10 66.2 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8NFZ0 CHOYP_FBXO18.2.2 m.52791 sp FBH1_HUMAN 39.099 821 460 17 297 1095 194 996 1.13E-168 528 FBH1_HUMAN reviewed F-box DNA helicase 1 (hFBH1) (EC 3.6.4.12) (F-box only protein 18) FBXO18 FBH1 FBX18 Homo sapiens (Human) 1043 "cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of chromatin binding [GO:0035562]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; replication fork protection [GO:0048478]; response to intra-S DNA damage checkpoint signaling [GO:0072429]" GO:0000724; GO:0000737; GO:0000785; GO:0001934; GO:0003678; GO:0003690; GO:0003697; GO:0004003; GO:0005524; GO:0005634; GO:0006974; GO:0008219; GO:0015616; GO:0016567; GO:0019005; GO:0031297; GO:0035562; GO:0043138; GO:0048478; GO:0072429; GO:1902231; GO:2000042 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25585578}. 0 0 PF12937;PF13361; Q8R0N9 CHOYP_LOC100375920.1.1 m.51239 sp ZDHC1_MOUSE 37.651 332 186 8 12 336 34 351 1.13E-50 185 ZDHC1_MOUSE reviewed Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) Zdhhc1 Mus musculus (Mouse) 484 protein palmitoylation [GO:0018345] GO:0005783; GO:0008270; GO:0016021; GO:0016409; GO:0018345; GO:0019706; GO:0070062 0 0 0 PF01529; Q8VCW8 CHOYP_ACSF2.4.4 m.62229 sp ACSF2_MOUSE 27.74 584 341 28 21 564 72 614 1.13E-38 153 ACSF2_MOUSE reviewed "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" Acsf2 Mus musculus (Mouse) 615 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005739; GO:0006631; GO:0016874 0 0 0 PF00501;PF13193; Q8VED2 CHOYP_TRIADDRAFT_55559.1.1 m.59545 sp BL1S4_MOUSE 36.719 128 78 2 52 176 80 207 1.13E-26 103 BL1S4_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog) Bloc1s4 Cno Mus musculus (Mouse) 215 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; melanosome organization [GO:0032438]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; platelet aggregation [GO:0070527] GO:0005737; GO:0008089; GO:0031083; GO:0031175; GO:0032438; GO:0048490; GO:0050885; GO:0070527; GO:1904115 0 0 0 0 Q90Z10 CHOYP_LOC100199467.1.1 m.20764 sp RL13_DANRE 68.02 197 63 0 16 212 6 202 1.13E-87 261 RL13_DANRE reviewed 60S ribosomal protein L13 rpl13 Danio rerio (Zebrafish) (Brachydanio rerio) 211 regulation of cell cycle [GO:0051726]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0051726 0 0 0 PF01294; Q96JB1 CHOYP_DYH8.1.2 m.25579 sp DYH8_HUMAN 71.545 123 35 0 1 123 3811 3933 1.13E-56 193 DYH8_HUMAN reviewed "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" DNAH8 Homo sapiens (Human) 4490 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018; GO:0016887; GO:0030286 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q96MM6 CHOYP_LOC100374651.1.4 m.28869 sp HS12B_HUMAN 29.352 586 332 16 15 532 101 672 1.13E-79 266 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96T88 CHOYP_LOC756912.2.2 m.45193 sp UHRF1_HUMAN 46.809 188 75 5 106 275 411 591 1.13E-41 157 UHRF1_HUMAN reviewed E3 ubiquitin-protein ligase UHRF1 (EC 6.3.2.-) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) UHRF1 ICBP90 NP95 RNF106 Homo sapiens (Human) 793 "cell cycle [GO:0007049]; cell proliferation [GO:0008283]; DNA repair [GO:0006281]; histone monoubiquitination [GO:0010390]; histone ubiquitination [GO:0016574]; maintenance of DNA methylation [GO:0010216]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cellular protein metabolic process [GO:0032270]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autoubiquitination [GO:0051865]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of methylation-dependent chromatin silencing [GO:0090308]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0000791; GO:0000792; GO:0000987; GO:0003700; GO:0004842; GO:0005634; GO:0005657; GO:0005720; GO:0006281; GO:0006351; GO:0007049; GO:0008270; GO:0008283; GO:0008327; GO:0010216; GO:0010390; GO:0016363; GO:0016574; GO:0016874; GO:0031493; GO:0032270; GO:0035064; GO:0042393; GO:0042787; GO:0042802; GO:0044729; GO:0045944; GO:0051865; GO:0061630; GO:0090308; GO:2000373 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00628;PF02182;PF12148;PF00240; Q98925 CHOYP_IRF1.2.3 m.58463 sp IRF2_CHICK 53.846 78 35 1 19 95 2 79 1.13E-22 92.8 IRF2_CHICK reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) 348 cell proliferation [GO:0008283] GO:0000977; GO:0001228; GO:0005654; GO:0005737; GO:0005925; GO:0008283 0 0 0 PF00605; Q99020 CHOYP_KLPA.1.1 m.50157 sp ROAA_MOUSE 54.248 153 65 2 36 184 54 205 1.13E-46 157 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q99442 CHOYP_SEC62.3.3 m.31109 sp SEC62_HUMAN 47 100 49 3 1 99 1 97 1.13E-17 82.8 SEC62_HUMAN reviewed Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) SEC62 TLOC1 Homo sapiens (Human) 399 cotranslational protein targeting to membrane [GO:0006613]; IRE1-mediated unfolded protein response [GO:0036498]; posttranslational protein targeting to membrane [GO:0006620] GO:0004872; GO:0005783; GO:0005789; GO:0005791; GO:0005829; GO:0006613; GO:0006620; GO:0008565; GO:0016020; GO:0016021; GO:0016235; GO:0036498; GO:0045111 0 0 0 PF03839; Q9BYX4 CHOYP_LOC100378083.1.3 m.26711 sp IFIH1_HUMAN 27.001 837 442 24 36 783 261 1017 1.13E-53 204 IFIH1_HUMAN reviewed Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) IFIH1 MDA5 RH116 Homo sapiens (Human) 1025 cytoplasmic pattern recognition receptor signaling pathway in response to virus [GO:0039528]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; negative regulation of type I interferon production [GO:0032480]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; protein sumoylation [GO:0016925]; regulation of type III interferon production [GO:0034344]; response to virus [GO:0009615] GO:0003677; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005634; GO:0005829; GO:0008270; GO:0009597; GO:0009615; GO:0016925; GO:0032480; GO:0032727; GO:0032728; GO:0034344; GO:0039528; GO:0039530; GO:0043021; GO:0045087 0 0 0 PF16739;PF00271;PF04851;PF11648; Q9DE14 CHOYP_ATR.1.1 m.18042 sp ATR_XENLA 24.211 190 131 4 172 353 548 732 1.13E-08 60.8 ATR_XENLA reviewed Serine/threonine-protein kinase atr (Xatr) (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) atr Xenopus laevis (African clawed frog) 2654 DNA repair [GO:0006281]; peptidyl-serine phosphorylation [GO:0018105] GO:0003677; GO:0004674; GO:0005524; GO:0006281; GO:0016605; GO:0018105; GO:0046982 0 0 0 PF02259;PF02260;PF00454;PF08064; Q9EPR2 CHOYP_LOC100116717.1.2 m.15196 sp PG12A_MOUSE 35.329 167 101 5 18 180 21 184 1.13E-26 106 PG12A_MOUSE reviewed Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) Pla2g12a Pla2g12 Mus musculus (Mouse) 192 lipid catabolic process [GO:0016042] GO:0004623; GO:0005509; GO:0005576; GO:0005622; GO:0005783; GO:0005794; GO:0016042 0 0 0 PF06951; Q9ER71 CHOYP_LOC445704.1.1 m.33521 sp RHOJ_MOUSE 32.667 150 101 0 15 164 58 207 1.13E-24 97.8 RHOJ_MOUSE reviewed Rho-related GTP-binding protein RhoJ (Tc10-like GTP-binding protein) Rhoj Arhj Rhoi Rhot Tc10l Tcl Mus musculus (Mouse) 214 actin cytoskeleton organization [GO:0030036]; regulation of cell shape [GO:0008360]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; Rho protein signal transduction [GO:0007266] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007266; GO:0008360; GO:0030036; GO:0061299; GO:0070062 0 0 0 PF00071; Q9NS73 CHOYP_LOC100372348.1.1 m.15165 sp MBIP1_HUMAN 42.714 199 94 7 136 330 150 332 1.13E-39 145 MBIP1_HUMAN reviewed MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) MBIP BM-015 Homo sapiens (Human) 344 histone H3 acetylation [GO:0043966]; inactivation of MAPK activity involved in osmosensory signaling pathway [GO:0000173] GO:0000173; GO:0004860; GO:0005634; GO:0005671; GO:0005730; GO:0005737; GO:0042802; GO:0043966 0 0 0 0 Q9P2E3 CHOYP_ZNFX1.7.12 m.49486 sp ZNFX1_HUMAN 26.503 366 202 13 1 333 1546 1877 1.13E-22 104 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9QXT1 CHOYP_LOC100631809.1.2 m.30895 sp DAPP1_MOUSE 44.371 151 77 3 14 160 111 258 1.13E-38 135 DAPP1_MOUSE reviewed Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (mDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa) Dapp1 Bam32 Mus musculus (Mouse) 280 0 GO:0005547; GO:0005737; GO:0005886; GO:0043325 0 0 0 PF00169;PF00017; Q9WTK3 CHOYP_LOC664158.2.2 m.21884 sp GPAA1_MOUSE 43.182 264 143 3 1 262 1 259 1.13E-65 218 GPAA1_MOUSE reviewed Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (mGAA1) Gpaa1 Gaa1 Mus musculus (Mouse) 621 attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506] GO:0003923; GO:0005887; GO:0006506; GO:0016020; GO:0016255; GO:0034235; GO:0042765 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF04114; Q9XWD6 CHOYP_MEG10.38.91 m.39831 sp CED1_CAEEL 37.118 229 134 6 189 416 637 856 1.13E-27 119 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; Q9Y5K3 CHOYP_ISCW_ISCW012957.2.2 m.52357 sp PCY1B_HUMAN 54.514 288 111 4 44 315 38 321 1.13E-114 340 PCY1B_HUMAN reviewed Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) 369 ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid biosynthetic process [GO:0008654]; spermatogenesis [GO:0007283] GO:0001541; GO:0004105; GO:0005737; GO:0005789; GO:0006656; GO:0007283; GO:0008654 PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. {ECO:0000250|UniProtKB:P19836}. 0 0 PF01467; A0JM12 CHOYP_CED1.17.29 m.40282 sp MEG10_XENTR 36.17 94 55 2 1 91 284 375 1.14E-10 60.8 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A0JM12 CHOYP_MEG11.5.25 m.24214 sp MEG10_XENTR 40.329 243 128 9 216 457 601 827 1.14E-36 150 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AKX3 CHOYP_SETX.1.1 m.41278 sp SETX_MOUSE 29.335 842 466 29 380 1173 1682 2442 1.14E-85 310 SETX_MOUSE reviewed Probable helicase senataxin (EC 3.6.4.-) (Amyotrophic lateral sclerosis 4 protein homolog) (SEN1 homolog) Setx Als4 Kiaa0625 Mus musculus (Mouse) 2646 "cellular response to DNA damage stimulus [GO:0006974]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; DNA recombination [GO:0006310]; DNA-templated transcription, termination [GO:0006353]; double-strand break repair [GO:0006302]; fibroblast growth factor receptor signaling pathway [GO:0008543]; MAPK cascade [GO:0000165]; mRNA splice site selection [GO:0006376]; negative regulation of apoptotic process [GO:0043066]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of DNA-templated transcription, termination [GO:0060566]; positive regulation of neuron projection development [GO:0010976]; positive regulation of RNA splicing [GO:0033120]; positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [GO:2000806]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein kinase B signaling [GO:0043491]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000165; GO:0000228; GO:0000781; GO:0001147; GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006302; GO:0006310; GO:0006353; GO:0006369; GO:0006376; GO:0006974; GO:0007283; GO:0007623; GO:0008543; GO:0010976; GO:0030424; GO:0030426; GO:0033120; GO:0034599; GO:0042802; GO:0043066; GO:0043491; GO:0044344; GO:0045944; GO:0060566; GO:0070301; GO:0071300; GO:2000144; GO:2000806 0 0 0 0 A4IHW6 CHOYP_GNPI2.1.1 m.55897 sp GNPI2_XENTR 84.27 267 42 0 1 267 1 267 1.14E-171 478 GNPI2_XENTR reviewed Glucosamine-6-phosphate isomerase 2 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 2) (GNPDA 2) (GlcN6P deaminase 2) gnpda2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 275 carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0004342; GO:0005737; GO:0005975; GO:0006046; GO:0006048; GO:0016787; GO:0019262 0 0 cd01399; PF01182; A4IIY1 CHOYP_LOC100371864.1.1 m.51198 sp R144A_XENTR 30.178 169 97 6 125 286 62 216 1.14E-08 58.9 R144A_XENTR reviewed Probable E3 ubiquitin-protein ligase RNF144A (EC 6.3.2.-) (RING finger protein 144A) rnf144a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 292 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005794; GO:0008270; GO:0016021; GO:0016874; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; A5VJD5 CHOYP_LOC100377759.2.15 m.1444 sp DPO3_LACRD 27.461 193 110 8 219 399 387 561 1.14E-08 61.6 DPO3_LACRD reviewed DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC Lreu_0694 Lactobacillus reuteri (strain DSM 20016) 1443 DNA-dependent DNA replication [GO:0006261] GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 0 0 0 PF14480;PF11490;PF07733;PF14579;PF02811;PF00929; B5X4E0 CHOYP_DPSE_GA16367.1.1 m.22618 sp CALUB_SALSA 36.923 325 184 6 1 319 3 312 1.14E-61 201 CALUB_SALSA reviewed Calumenin-B calub Salmo salar (Atlantic salmon) 316 0 GO:0005509; GO:0005576; GO:0005789; GO:0005794; GO:0033018; GO:0042470 0 0 0 PF13202;PF13833; C3RZA1 CHOYP_LOC100893269.1.1 m.10415 sp SMYD2_PIG 57.5 40 17 0 12 51 52 91 1.14E-10 64.7 SMYD2_PIG reviewed N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (Histone methyltransferase SMYD2) (EC 2.1.1.43) (SET and MYND domain-containing protein 2) SMYD2 Sus scrofa (Pig) 433 "negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000993; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0008285; GO:0016279; GO:0018026; GO:0018027; GO:0043516; GO:0046872; GO:0046975 0 0 0 PF00856;PF01753; F1LZ52 CHOYP_LOC100083167.1.1 m.46715 sp KLHL3_RAT 37.398 123 69 4 49 169 402 518 1.14E-15 77 KLHL3_RAT reviewed Kelch-like protein 3 Klhl3 Rattus norvegicus (Rat) 588 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; G5E8K5 CHOYP_LOC764037.1.1 m.35432 sp ANK3_MOUSE 23.575 386 253 11 292 669 312 663 1.14E-21 104 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O01761 CHOYP_MYLK.1.4 m.1552 sp UNC89_CAEEL 36.735 98 58 3 50 145 5378 5473 1.14E-09 59.3 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O08893 CHOYP_CALCR.1.6 m.856 sp CALCR_CAVPO 37.366 372 221 8 29 395 59 423 1.14E-75 246 CALCR_CAVPO reviewed Calcitonin receptor (CT-R) CALCR Cavia porcellus (Guinea pig) 478 cell surface receptor signaling pathway [GO:0007166] GO:0004948; GO:0005886; GO:0007166; GO:0016021 0 0 0 PF00002;PF02793; O14545 CHOYP_LOC100368148.1.1 m.272 sp TRAD1_HUMAN 28.395 405 231 12 4 369 6 390 1.14E-38 154 TRAD1_HUMAN reviewed TRAF-type zinc finger domain-containing protein 1 (Protein FLN29) TRAFD1 FLN29 Homo sapiens (Human) 582 negative regulation of innate immune response [GO:0045824]; response to cytokine [GO:0034097] GO:0034097; GO:0045824; GO:0046872 0 0 0 0 O46037 CHOYP_BRAFLDRAFT_91289.1.2 m.10407 sp VINC_DROME 33.333 108 56 3 8 109 863 960 1.14E-06 50.1 VINC_DROME reviewed Vinculin Vinc CG3299 Drosophila melanogaster (Fruit fly) 961 cell adhesion [GO:0007155]; cytoskeletal anchoring at plasma membrane [GO:0007016]; neuron projection morphogenesis [GO:0048812]; phagocytosis [GO:0006909] GO:0003779; GO:0005198; GO:0005737; GO:0005886; GO:0005925; GO:0006909; GO:0007016; GO:0007155; GO:0015629; GO:0048812 0 0 0 PF01044; O46581 CHOYP_VWDE.8.13 m.38775 sp COX41_THEGE 31.655 139 84 4 73 205 10 143 1.14E-17 79.7 COX41_THEGE reviewed "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) (Fragment)" COX4I1 COX4 Theropithecus gelada (Gelada baboon) 144 0 GO:0004129; GO:0005743 0 0 cd00922; PF02936; O57592 CHOYP_P66A.1.1 m.22281 sp RL7A_TAKRU 75.735 136 31 1 2 137 72 205 1.14E-68 211 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O60462 CHOYP_CUBN.5.7 m.60325 sp NRP2_HUMAN 29.646 226 126 13 56 266 45 252 1.14E-16 84.7 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O75382 CHOYP_contig_045324 m.52686 sp TRIM3_HUMAN 27.049 122 81 2 166 279 622 743 1.14E-06 54.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75575 CHOYP_M3K7.1.4 m.7881 sp RPC9_HUMAN 56.061 132 55 1 1 129 1 132 1.14E-34 120 RPC9_HUMAN reviewed DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) CRCP Homo sapiens (Human) 148 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuropeptide signaling pathway [GO:0007218]; positive regulation of type I interferon production [GO:0032481]; transcription from RNA polymerase III promoter [GO:0006383]; transcription initiation from RNA polymerase III promoter [GO:0006384] GO:0000166; GO:0001635; GO:0001669; GO:0003899; GO:0005654; GO:0005666; GO:0005829; GO:0005886; GO:0006383; GO:0006384; GO:0007218; GO:0009360; GO:0032481; GO:0045087; GO:0051607 0 0 0 PF03874; O77245 CHOYP_E75.1.3 m.58443 sp E75_METEN 25.157 159 111 5 82 238 213 365 1.14E-06 52.4 E75_METEN reviewed Nuclear hormone receptor E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis) 606 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; P05099 CHOYP_LOC582329.1.2 m.3042 sp MATN1_CHICK 24.167 360 218 11 31 343 33 384 1.14E-19 94.7 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P08941 CHOYP_BRAFLDRAFT_125708.1.1 m.66017 sp ROS1_CHICK 26.087 207 137 4 43 249 57 247 1.14E-14 77.4 ROS1_CHICK reviewed Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase) ROS1 Gallus gallus (Chicken) 2311 cell differentiation [GO:0030154]; cell growth [GO:0016049]; cell proliferation [GO:0008283]; columnar/cuboidal epithelial cell development [GO:0002066]; protein phosphorylation [GO:0006468]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of TOR signaling [GO:0032006]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0002066; GO:0004713; GO:0004714; GO:0005524; GO:0005886; GO:0006468; GO:0007169; GO:0008283; GO:0016021; GO:0016049; GO:0030154; GO:0032006; GO:0070372 0 0 0 PF00041;PF07714; P0CB49 CHOYP_LOC100553687.1.1 m.61663 sp YLPM1_RAT 57.229 332 129 6 1157 1479 1049 1376 1.14E-110 386 YLPM1_RAT reviewed YLP motif-containing protein 1 (Nuclear protein ZAP3) Ylpm1 Zap Zap3 Rattus norvegicus (Rat) 1376 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0016607 0 0 0 0 P0DH96 CHOYP_CPIPJ_CPIJ007602.1.1 m.30721 sp CALM4_ARATH 46.897 145 77 0 4 148 5 149 1.14E-45 149 CALM4_ARATH reviewed Calmodulin-4 (CaM-4) CAM4 At1g66410 F28G11.13 T27F4.1 Arabidopsis thaliana (Mouse-ear cress) 149 0 GO:0005509 0 0 0 PF13499; P15454 CHOYP_GUK1.1.1 m.48140 sp KGUA_YEAST 57.143 182 76 2 31 211 3 183 1.14E-73 224 KGUA_YEAST reviewed Guanylate kinase (EC 2.7.4.8) (GMP kinase) GUK1 YDR454C D9461.39 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 187 GDP biosynthetic process [GO:0046711]; purine nucleotide metabolic process [GO:0006163] GO:0004385; GO:0005524; GO:0006163; GO:0046711 0 0 0 PF00625; P18503 CHOYP_BRAFLDRAFT_76550.14.21 m.60317 sp CAS4_EPHMU 36.364 121 55 5 78 194 207 309 1.14E-09 61.6 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P19382 CHOYP_SNAIL.1.1 m.10356 sp SNAI1_XENLA 75 144 36 0 163 306 109 252 1.14E-74 233 SNAI1_XENLA reviewed Protein snail homolog Sna (Protein Xsnail) (Protein xSna) snai1 sna Xenopus laevis (African clawed frog) 259 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural crest cell fate specification [GO:0014036]; neural crest cell migration [GO:0001755]; neural crest formation [GO:0014029]" GO:0000122; GO:0001755; GO:0003677; GO:0005634; GO:0014029; GO:0014036; GO:0045892; GO:0046872 0 0 0 PF00096;PF13912; P42674 CHOYP_LOC100378969.1.2 m.23160 sp BP10_PARLI 36.882 263 146 6 66 315 67 322 1.14E-36 149 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P49020 CHOYP_BRAFLDRAFT_127851.1.1 m.10499 sp TMED2_CRIGR 80.22 182 35 1 22 203 16 196 1.14E-109 315 TMED2_CRIGR reviewed Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (p24 family protein beta-1) (p24beta1) (Fragment) TMED2 RNP24 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 196 Golgi organization [GO:0007030]; negative regulation of GTPase activity [GO:0034260]; protein targeting to plasma membrane [GO:0072661]; vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0007030; GO:0016021; GO:0016192; GO:0030137; GO:0030663; GO:0032580; GO:0033116; GO:0034260; GO:0072661 0 0 0 PF01105; P58308 CHOYP_LOC100742013.1.1 m.36818 sp OX2R_MOUSE 35.772 369 207 7 31 373 42 406 1.14E-73 240 OX2R_MOUSE reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P83088 CHOYP_LOC663075.2.2 m.46423 sp FUCTC_DROME 29.499 339 197 9 73 374 82 415 1.14E-39 149 FUCTC_DROME reviewed "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) 425 protein glycosylation [GO:0006486] GO:0006486; GO:0008417; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q08509 CHOYP_EPS-8.1.1 m.17522 sp EPS8_MOUSE 31.518 606 330 24 36 594 17 584 1.14E-64 236 EPS8_MOUSE reviewed Epidermal growth factor receptor kinase substrate 8 Eps8 Mus musculus (Mouse) 821 actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360] GO:0003779; GO:0005903; GO:0005938; GO:0008344; GO:0008360; GO:0010458; GO:0014069; GO:0016601; GO:0017146; GO:0030054; GO:0030426; GO:0030832; GO:0031532; GO:0031982; GO:0032420; GO:0032587; GO:0035591; GO:0036336; GO:0045202; GO:0048149; GO:0048365; GO:0051016; GO:0051017; GO:0051764; GO:0070062; GO:0070358 0 0 0 PF08416;PF00018; Q10982 CHOYP_LOC100497569.2.2 m.54698 sp FUT2_PIG 26.299 308 196 12 192 482 37 330 1.14E-22 102 FUT2_PIG reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Sus scrofa (Pig) 340 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q1T7B7 CHOYP_CENPP.1.1 m.46083 sp CENPP_CHICK 29.864 221 147 6 94 308 65 283 1.14E-17 84.7 CENPP_CHICK reviewed Centromere protein P (CENP-P) CENPP Gallus gallus (Chicken) 287 CENP-A containing nucleosome assembly [GO:0034080] GO:0000775; GO:0005634; GO:0034080 0 0 0 PF13096; Q24817 CHOYP_RHO3.1.1 m.66040 sp RACD_ENTHI 35.417 96 61 1 5 100 9 103 1.14E-13 66.2 RACD_ENTHI reviewed Rho-related protein racD (Fragment) RACD Entamoeba histolytica 198 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264 0 0 0 PF00071; Q29RZ1 CHOYP_BRAFLDRAFT_114709.1.1 m.17349 sp PDDC1_BOVIN 54.264 129 58 1 19 147 23 150 1.14E-45 151 PDDC1_BOVIN reviewed Parkinson disease 7 domain-containing protein 1 PDDC1 Bos taurus (Bovine) 220 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] GO:0019172; GO:0019243; GO:0070062 0 0 0 0 Q2KJC3 CHOYP_MPEG1.4.5 m.49975 sp MPEG1_BOVIN 38.963 675 372 13 56 719 45 690 1.14E-158 479 MPEG1_BOVIN reviewed Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Bos taurus (Bovine) 717 0 GO:0016021 0 0 0 PF01823; Q2V898 CHOYP_LOC590735.1.1 m.21409 sp TLR4_BOSTR 24.359 234 163 7 37 267 413 635 1.14E-09 62.8 TLR4_BOSTR reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Boselaphus tragocamelus (Nilgai) 841 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142] GO:0001875; GO:0002755; GO:0004888; GO:0005886; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13306;PF13855;PF01582; Q3MHN0 CHOYP_LOC100375089.1.1 m.1341 sp PSB6_BOVIN 66.827 208 69 0 7 214 24 231 1.14E-106 309 PSB6_BOVIN reviewed Proteasome subunit beta type-6 (EC 3.4.25.1) PSMB6 Bos taurus (Bovine) 239 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004298; GO:0005654; GO:0005794; GO:0005839; GO:0051603; GO:0070062 0 0 0 PF00227; Q3MIT2 CHOYP_PUS10.1.1 m.16021 sp PUS10_HUMAN 41.714 525 257 4 15 493 8 529 1.14E-139 415 PUS10_HUMAN reviewed Putative tRNA pseudouridine synthase Pus10 (EC 5.4.99.-) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) PUS10 CCDC139 DOBI Homo sapiens (Human) 529 tRNA pseudouridine synthesis [GO:0031119] GO:0003723; GO:0009982; GO:0031119 0 0 0 0 Q460N5 CHOYP_SI_CH211-219A4.3.2.2 m.50881 sp PAR14_HUMAN 22.597 770 452 27 27 692 808 1537 1.14E-29 130 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q49AM3 CHOYP_LOC100368918.1.2 m.6229 sp TTC31_HUMAN 45.455 110 59 1 312 421 304 412 1.14E-20 99.8 TTC31_HUMAN reviewed Tetratricopeptide repeat protein 31 (TPR repeat protein 31) TTC31 Homo sapiens (Human) 519 0 0 0 0 0 0 Q4P821 CHOYP_CPIPJ_CPIJ019817.1.1 m.47825 sp COX19_USTMA 51.613 62 30 0 27 88 17 78 1.14E-18 79.7 COX19_USTMA reviewed Cytochrome c oxidase assembly protein COX19 COX19 UMAG_12241 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 176 aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex IV assembly [GO:0033617] GO:0005758; GO:0009060; GO:0033617 0 0 0 PF06747; Q4R532 CHOYP_LOC101435247.1.1 m.44854 sp SYNG1_MACFA 28.049 82 59 0 92 173 173 254 1.14E-06 50.4 SYNG1_MACFA reviewed Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) SYNDIG1 TMEM90B QccE-21894 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 258 intracellular protein transport [GO:0006886]; positive regulation of synapse assembly [GO:0051965]; response to biotic stimulus [GO:0009607]; synaptic vesicle clustering [GO:0097091] GO:0005887; GO:0006886; GO:0009607; GO:0014069; GO:0030054; GO:0031901; GO:0035254; GO:0042803; GO:0043197; GO:0043198; GO:0044297; GO:0045211; GO:0051965; GO:0060076; GO:0097091; GO:0098793 0 0 0 PF04505; Q4ZJM9 CHOYP_C1QRF.2.3 m.29625 sp C1QL4_MOUSE 37.589 141 72 7 144 283 110 235 1.14E-07 55.1 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q4ZJM9 CHOYP_LOC101158517.3.3 m.64320 sp C1QL4_MOUSE 34.266 143 77 6 31 172 109 235 1.14E-08 55.8 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5R9J9 CHOYP_BRAFLDRAFT_114158.1.1 m.24733 sp TPPC4_PONAB 63.679 212 76 1 1 212 1 211 1.14E-106 308 TPPC4_PONAB reviewed Trafficking protein particle complex subunit 4 TRAPPC4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 219 dendrite development [GO:0016358]; vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005795; GO:0008021; GO:0016192; GO:0016358; GO:0030008; GO:0030425 0 0 0 PF04099; Q5R9J9 CHOYP_LNX2.1.1 m.32076 sp TPPC4_PONAB 63.679 212 76 1 1 212 1 211 1.14E-106 308 TPPC4_PONAB reviewed Trafficking protein particle complex subunit 4 TRAPPC4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 219 dendrite development [GO:0016358]; vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005795; GO:0008021; GO:0016192; GO:0016358; GO:0030008; GO:0030425 0 0 0 PF04099; Q5XHA1 CHOYP_ISCW_ISCW004209.1.1 m.18879 sp MED27_XENTR 40.316 253 148 2 44 296 62 311 1.14E-65 211 MED27_XENTR reviewed Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) med27 crsp8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 311 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11571; Q5ZID0 CHOYP_LOC100370600.1.1 m.29572 sp NMRL1_CHICK 31.544 298 189 9 3 295 5 292 1.14E-42 151 NMRL1_CHICK reviewed NmrA-like family domain-containing protein 1 NMRAL1 RCJMB04_27o15 Gallus gallus (Chicken) 296 0 GO:0005634; GO:0048471 0 0 0 PF05368; Q5ZLK8 CHOYP_U669.1.1 m.35105 sp CF120_CHICK 32.584 178 102 4 39 209 18 184 1.14E-28 108 CF120_CHICK reviewed UPF0669 protein C6orf120 homolog RCJMB04_5l6 Gallus gallus (Chicken) 185 0 GO:0005576 0 0 0 PF17065; Q60803 CHOYP_LOC101161601.1.1 m.27318 sp TRAF3_MOUSE 42.593 540 278 10 31 558 45 564 1.14E-138 416 TRAF3_MOUSE reviewed TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) 567 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; toll-like receptor signaling pathway [GO:0002224]; Toll signaling pathway [GO:0008063]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005768; GO:0006915; GO:0008063; GO:0008270; GO:0009898; GO:0016874; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032088; GO:0032648; GO:0033209; GO:0035631; GO:0042981; GO:0045087; GO:0050688 0 0 0 PF02176; Q61847 CHOYP_NEMVEDRAFT_V1G104208.1.1 m.5890 sp MEP1B_MOUSE 31.902 163 98 6 67 226 104 256 1.14E-11 67.4 MEP1B_MOUSE reviewed Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) Mep1b Mep-1b Mus musculus (Mouse) 704 inflammatory response [GO:0006954]; toxin transport [GO:1901998] GO:0004222; GO:0005576; GO:0005886; GO:0006954; GO:0008270; GO:0016020; GO:0016021; GO:1901998 0 0 cd06263; PF01400;PF00008;PF00629; Q642H9 CHOYP_PDHA1.1.1 m.42808 sp RS4X_DANRE 76.543 243 57 0 1 243 19 261 1.14E-143 405 RS4X_DANRE reviewed "40S ribosomal protein S4, X isoform" rps4x rps4 zgc:92076 Danio rerio (Zebrafish) (Brachydanio rerio) 263 brain development [GO:0007420]; chordate embryonic development [GO:0043009]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0007420; GO:0019843; GO:0022627; GO:0043009 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q6DIB5 CHOYP_MEGF11.5.11 m.46938 sp MEG10_MOUSE 39.024 246 130 13 167 411 344 570 1.14E-27 120 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6NWC6 CHOYP_LOC100372147.2.2 m.56744 sp CPSF6_DANRE 60.588 170 59 5 350 518 352 514 1.14E-46 174 CPSF6_DANRE reviewed Cleavage and polyadenylation specificity factor subunit 6 cpsf6 Danio rerio (Zebrafish) (Brachydanio rerio) 545 mRNA polyadenylation [GO:0006378] GO:0000166; GO:0003729; GO:0005634; GO:0005849; GO:0006378 0 0 0 PF00076; Q6PDJ1 CHOYP_BRAFLDRAFT_93676.1.1 m.17031 sp CAHD1_MOUSE 22.659 737 476 26 1 677 354 1056 1.14E-35 152 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6PFY8 CHOYP_TRIM45.2.9 m.12949 sp TRI45_MOUSE 26.131 199 124 8 5 189 129 318 1.14E-09 63.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7Z7G8 CHOYP_BRAFLDRAFT_75094.1.2 m.24898 sp VP13B_HUMAN 39.082 632 361 13 1059 1676 3400 4021 1.14E-116 414 VP13B_HUMAN reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) 4022 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q811M1 CHOYP_RHG27.1.1 m.38192 sp RHG15_MOUSE 37.157 401 214 9 116 496 94 476 1.14E-86 277 RHG15_MOUSE reviewed Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15) Arhgap15 Mus musculus (Mouse) 481 regulation of cell shape [GO:0008360]; signal transduction [GO:0007165] GO:0005096; GO:0005737; GO:0007165; GO:0008360; GO:0016020 0 0 0 PF00169;PF00620; Q86VP3 CHOYP_LOC557305.1.1 m.18011 sp PACS2_HUMAN 38.846 520 290 12 267 773 380 884 1.14E-104 344 PACS2_HUMAN reviewed Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) PACS2 KIAA0602 PACS1L Homo sapiens (Human) 889 apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; protein localization to pre-autophagosomal structure [GO:0034497]; protein targeting to plasma membrane [GO:0072661]; viral process [GO:0016032] GO:0000045; GO:0005739; GO:0005783; GO:0005788; GO:0006915; GO:0016032; GO:0034497; GO:0044325; GO:0072661 0 0 0 PF10254; Q8BV79 CHOYP_BRAFLDRAFT_118709.3.4 m.52468 sp TRNK1_MOUSE 30.97 536 352 7 1 527 1553 2079 1.14E-67 242 TRNK1_MOUSE reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1) Trank1 Gm187 Kiaa0342 Lba1 Mus musculus (Mouse) 2999 0 0 0 0 0 0 Q8BZ25 CHOYP_TVAG_291510.8.9 m.51135 sp ANKK1_MOUSE 24.762 315 188 9 6 301 395 679 1.14E-16 88.6 ANKK1_MOUSE reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) 745 0 GO:0004674; GO:0005524 0 0 0 PF00023;PF12796;PF07714; Q8HXX6 CHOYP_BRAFLDRAFT_124972.5.5 m.56782 sp SAP3_MACFA 33.526 173 103 4 98 259 16 187 1.14E-29 113 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8K0U4 CHOYP_HSPA12A.8.27 m.31384 sp HS12A_MOUSE 28.699 561 330 16 44 549 129 674 1.14E-55 201 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K2X2 CHOYP_LOC100366729.1.1 m.33896 sp RBM48_MOUSE 44.037 218 97 5 39 256 14 206 1.14E-49 176 RBM48_MOUSE reviewed RNA-binding protein 48 Rbm48 Mus musculus (Mouse) 371 0 GO:0000166; GO:0003723; GO:0005654 0 0 0 0 Q8MP06 CHOYP_NEMVEDRAFT_V1G235461.1.1 m.28341 sp SNO1_TYRJA 34.615 260 156 7 2 252 188 442 1.14E-32 127 SNO1_TYRJA reviewed Senecionine N-oxygenase (SNO) (EC 1.14.13.101) sno1 Tyria jacobaeae (Cinnabar moth) 456 alkaloid metabolic process [GO:0009820]; oxidation-reduction process [GO:0055114]; protein homotetramerization [GO:0051289] GO:0004499; GO:0005576; GO:0009820; GO:0033784; GO:0050660; GO:0050661; GO:0051289; GO:0055114 0 0 0 PF00743; Q8N8K9 CHOYP_BRAFLDRAFT_117219.1.1 m.49022 sp K1958_HUMAN 26.891 238 168 5 115 350 449 682 1.14E-10 68.6 K1958_HUMAN reviewed Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) 716 0 GO:0000981; GO:0003677; GO:0005654; GO:0005737 0 0 0 PF12012; Q8N9M1 CHOYP_KDM2B.1.1 m.58689 sp CS047_HUMAN 39.568 278 135 9 23 287 39 296 1.14E-42 158 CS047_HUMAN reviewed Uncharacterized protein C19orf47 C19orf47 Homo sapiens (Human) 422 0 GO:0005654 0 0 0 0 Q8N9W6 CHOYP_LOC100892519.3.4 m.15139 sp BOLL_HUMAN 50 200 77 9 21 218 22 200 1.14E-46 166 BOLL_HUMAN reviewed Protein boule-like BOLL BOULE Homo sapiens (Human) 283 cell differentiation [GO:0030154]; meiotic nuclear division [GO:0007126]; multicellular organism development [GO:0007275]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283] GO:0000166; GO:0003723; GO:0005737; GO:0007126; GO:0007275; GO:0007283; GO:0008494; GO:0030154; GO:0045948 0 0 0 PF00076; Q8TAA9 CHOYP_VANG.1.1 m.18057 sp VANG1_HUMAN 51.154 520 228 11 38 553 27 524 1.14E-159 468 VANG1_HUMAN reviewed Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1) VANGL1 STB2 Homo sapiens (Human) 524 "multicellular organism development [GO:0007275]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0007275; GO:0016021; GO:0016328; GO:0060071 0 0 0 PF06638; Q8WZ42 CHOYP_LOC100114159.1.1 m.53867 sp TITIN_HUMAN 26.768 198 125 5 194 385 16353 16536 1.14E-06 55.8 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q92047 CHOYP_BRAFLDRAFT_284774.1.3 m.2024 sp PIMT_DANRE 64.286 224 78 1 44 267 1 222 1.14E-103 304 PIMT_DANRE reviewed Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) pcmt Danio rerio (Zebrafish) (Brachydanio rerio) 228 0 GO:0004719; GO:0005737 0 0 0 0 Q99315 CHOYP_LOC100142313.1.2 m.6132 sp YG31B_YEAST 30.597 938 549 23 334 1248 594 1452 1.14E-116 407 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9BXB1 CHOYP_CRI9333_2800.1.1 m.5332 sp LGR4_HUMAN 33.088 136 89 2 264 397 110 245 1.14E-12 73.9 LGR4_HUMAN reviewed Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) LGR4 GPR48 Homo sapiens (Human) 951 "bone mineralization [GO:0030282]; bone remodeling [GO:0046849]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cell differentiation involved in metanephros development [GO:0072202]; circadian regulation of gene expression [GO:0032922]; digestive tract development [GO:0048565]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; hair follicle development [GO:0001942]; innate immune response [GO:0045087]; intestinal stem cell homeostasis [GO:0036335]; male genitalia development [GO:0030539]; metanephric glomerulus development [GO:0072224]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transcription, DNA-templated [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription, DNA-templated [GO:0045893]; spermatogenesis [GO:0007283]" GO:0001649; GO:0001942; GO:0004888; GO:0004930; GO:0005886; GO:0005887; GO:0007283; GO:0030282; GO:0030539; GO:0032922; GO:0034122; GO:0036335; GO:0045087; GO:0045892; GO:0045893; GO:0046849; GO:0048565; GO:0050710; GO:0061290; GO:0072202; GO:0072224; GO:0072282; GO:0090190; GO:0090263; GO:2001013 0 0 0 PF00001;PF13855;PF01462; Q9CZJ2 CHOYP_HS12A.25.33 m.60352 sp HS12B_MOUSE 28.527 638 376 16 37 608 61 684 1.14E-80 271 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9EPH8 CHOYP_LOC657776.1.1 m.6110 sp PABP1_RAT 54.598 174 60 3 38 203 191 353 1.14E-50 176 PABP1_RAT reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Rattus norvegicus (Rat) 636 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0003729; GO:0005681; GO:0006397; GO:0008143; GO:0008380; GO:0010494; GO:0030425; GO:0030529; GO:0031047; GO:0060213; GO:1900153; GO:1990124; GO:2000623 0 0 0 PF00658;PF00076; Q9MYX8 CHOYP_LOC583995.2.2 m.23167 sp TAU_PAPHA 50.893 112 51 3 2 109 218 329 1.14E-26 105 TAU_PAPHA reviewed Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) MAPT TAU Papio hamadryas (Hamadryas baboon) 383 0 GO:0005829; GO:0005874; GO:0005886; GO:0030424 0 0 0 PF00418; Q9N5Y2 CHOYP_LOC100372208.1.1 m.18397 sp TECR_CAEEL 59.259 297 121 0 46 342 12 308 1.14E-133 385 TECR_CAEEL reviewed Probable very-long-chain enoyl-CoA reductase art-1 (EC 1.3.1.93) art-1 C15F1.6 Caenorhabditis elegans 308 fatty acid biosynthetic process [GO:0006633] GO:0005789; GO:0006633; GO:0016021; GO:0016627 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q9NZ01}. 0 0 PF02544;PF00240; Q9NXB0 CHOYP_BRAFLDRAFT_279949.1.1 m.54415 sp MKS1_HUMAN 42.78 554 297 7 547 1088 9 554 1.14E-139 435 MKS1_HUMAN reviewed Meckel syndrome type 1 protein MKS1 Homo sapiens (Human) 559 "branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; common bile duct development [GO:0061009]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial structure maintenance [GO:0010669]; head development [GO:0060322]; inner ear receptor stereocilium organization [GO:0060122]; motile primary cilium assembly [GO:1903887]; neural tube closure [GO:0001843]; nonmotile primary cilium assembly [GO:0035058]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]" GO:0001843; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0007368; GO:0010669; GO:0016020; GO:0035058; GO:0036038; GO:0036064; GO:0042384; GO:0042733; GO:0048706; GO:0048754; GO:0060122; GO:0060271; GO:0060322; GO:0060828; GO:0061009; GO:1901620; GO:1903887; GO:1990403; GO:2000095 0 0 0 PF07162; Q9QUN3 CHOYP_PHUM_PHUM128460.5.7 m.48715 sp BLNK_MOUSE 34.513 113 70 3 525 634 342 453 1.14E-14 80.5 BLNK_MOUSE reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) Blnk Bash Ly57 Slp65 Mus musculus (Mouse) 457 B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005737; GO:0005886; GO:0006955; GO:0035556; GO:0042113 0 0 0 PF00017; Q9R171 CHOYP_CBLN13.5.9 m.40086 sp CBLN1_MOUSE 28.144 167 106 5 35 196 34 191 1.14E-10 61.2 CBLN1_MOUSE reviewed Cerebellin-1 (Brain protein D3) (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser1-cerebellin)] Cbln1 Mus musculus (Mouse) 193 cerebellar granule cell differentiation [GO:0021707]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; positive regulation of synapse assembly [GO:0051965]; protein secretion [GO:0009306] GO:0005576; GO:0007157; GO:0009306; GO:0021707; GO:0030054; GO:0042803; GO:0045202; GO:0045211; GO:0051965 0 0 0 PF00386; Q9UGM3 CHOYP_BRAFLDRAFT_230523.1.3 m.34477 sp DMBT1_HUMAN 41.237 194 97 4 1 193 686 863 1.14E-32 127 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UH65 CHOYP_LOC100346427.1.1 m.44592 sp SWP70_HUMAN 30.303 594 353 14 67 625 7 574 1.14E-59 215 SWP70_HUMAN reviewed Switch-associated protein 70 (SWAP-70) SWAP70 KIAA0640 HSPC321 Homo sapiens (Human) 585 actin filament bundle assembly [GO:0051017]; isotype switching [GO:0045190]; negative regulation of actin filament depolymerization [GO:0030835]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of peptidyl-serine dephosphorylation [GO:1902309]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of protein localization [GO:0032880] GO:0003677; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005913; GO:0007204; GO:0030027; GO:0030835; GO:0032233; GO:0032880; GO:0033633; GO:0045190; GO:0051017; GO:0060754; GO:0098641; GO:1902309 0 0 0 PF00169; Q9VCA8 CHOYP_LOC100637968.7.12 m.38128 sp ANKHM_DROME 31.759 381 226 13 29 389 686 1052 1.14E-36 145 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VCP0 CHOYP_AAEL_AAEL010723.1.1 m.8187 sp ELOA1_DROME 31.176 170 89 4 21 183 24 172 1.14E-08 58.9 ELOA1_DROME reviewed Transcription elongation factor B polypeptide 3 (Elongin-A) (RNA polymerase II transcription factor SIII subunit A) (dEloA) EloA CG6755 Drosophila melanogaster (Fruit fly) 643 imaginal disc-derived wing vein specification [GO:0007474]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; transcription elongation from RNA polymerase II promoter [GO:0006368] GO:0003677; GO:0005634; GO:0006368; GO:0007474; GO:0008023; GO:0016021; GO:0032968; GO:0070449 0 0 0 PF06881;PF08711; Q9W6V2 CHOYP_NEGR1.1.1 m.35453 sp NEGR1_CHICK 32.484 314 179 10 6 306 18 311 1.14E-29 121 NEGR1_CHICK reviewed Neuronal growth regulator 1 (Neurotractin) NEGR1 NTRA Gallus gallus (Chicken) 352 feeding behavior [GO:0007631]; locomotory behavior [GO:0007626]; positive regulation of neuron projection development [GO:0010976]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007626; GO:0007631; GO:0010976; GO:0016337; GO:0031225; GO:0070062 0 0 0 PF07679; Q9WU63 CHOYP_LOC100634347.1.1 m.8105 sp HEBP2_MOUSE 36.275 102 52 5 38 133 35 129 1.14E-07 51.6 HEBP2_MOUSE reviewed Heme-binding protein 2 (Protein SOUL) Hebp2 Soul Mus musculus (Mouse) 205 negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of necrotic cell death [GO:0010940] GO:0005737; GO:0005739; GO:0010917; GO:0010940; GO:0035794; GO:0070062 0 0 0 PF04832; Q9Y4R7 CHOYP_LOC578867.5.5 m.50267 sp TTLL3_HUMAN 47.126 435 218 6 588 1012 179 611 1.14E-127 416 TTLL3_HUMAN reviewed Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) 772 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; protein polyglycylation [GO:0018094] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0035082; GO:0042384; GO:0070735; GO:0070736 0 0 0 PF03133; Q9Y6R7 CHOYP_FCGBP.3.4 m.35742 sp FCGBP_HUMAN 24 175 127 4 1 172 182 353 1.14E-08 59.3 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A0A0R4I9Y1 CHOYP_RNF213.2.4 m.5353 sp R213B_DANRE 43.128 633 324 13 1 623 2012 2618 1.15E-158 508 R213B_DANRE reviewed E3 ubiquitin-protein ligase rnf213-beta (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-B) (Mysterin-beta) (RING finger protein 213-B) (RING finger protein 213-beta) rnf213b Danio rerio (Zebrafish) (Brachydanio rerio) 5061 protein ubiquitination [GO:0016567] GO:0005829; GO:0008270; GO:0016567; GO:0016787; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A2AUC9 CHOYP_KLH41.1.1 m.56047 sp KLH41_MOUSE 27.434 339 218 7 18 350 284 600 1.15E-34 137 KLH41_MOUSE reviewed Kelch-like protein 41 (Kelch repeat and BTB domain-containing protein 10) Klhl41 Kbtbd10 Mus musculus (Mouse) 606 myofibril assembly [GO:0030239]; protein ubiquitination [GO:0016567]; regulation of lateral pseudopodium assembly [GO:0031275]; regulation of myoblast differentiation [GO:0045661]; regulation of myoblast proliferation [GO:2000291]; regulation of skeletal muscle cell differentiation [GO:2001014]; sarcomere organization [GO:0045214]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber development [GO:0048741] GO:0001726; GO:0005634; GO:0005737; GO:0005789; GO:0005856; GO:0005886; GO:0016567; GO:0030239; GO:0031143; GO:0031275; GO:0031430; GO:0031463; GO:0033017; GO:0035914; GO:0045214; GO:0045661; GO:0048741; GO:2000291; GO:2001014 0 0 0 PF07707;PF00651;PF01344; A2AX52 CHOYP_COCA1.4.6 m.55046 sp CO6A4_MOUSE 35.955 178 106 5 366 541 848 1019 1.15E-21 104 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A6BM72 CHOYP_LOC763793.4.7 m.25303 sp MEG11_HUMAN 36.478 477 268 22 2 469 372 822 1.15E-64 229 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; A6BM72 CHOYP_MEG10.30.91 m.34407 sp MEG11_HUMAN 37.455 275 144 12 134 393 473 734 1.15E-32 133 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; A6NF83 CHOYP_RN45S.2.5 m.14116 sp NUPR2_HUMAN 35.366 82 52 1 15 96 5 85 1.15E-07 48.5 NUPR2_HUMAN reviewed Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2) NUPR2 NUPR1L Homo sapiens (Human) 97 "cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to starvation [GO:0009267]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003682; GO:0005634; GO:0006351; GO:0006974; GO:0007050; GO:0008285; GO:0009267; GO:0071157 0 0 0 PF10195; A6X942 CHOYP_LOC576200.3.4 m.38681 sp SH24B_MOUSE 36.131 429 212 14 31 434 19 410 1.15E-53 187 SH24B_MOUSE reviewed SH2 domain-containing protein 4B Sh2d4b Mus musculus (Mouse) 431 0 0 0 0 0 PF00017; B2IZD3 CHOYP_BRAFLDRAFT_89869.1.3 m.28871 sp BDLP_NOSP7 25 216 131 7 216 426 55 244 1.15E-08 63.2 BDLP_NOSP7 reviewed Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5) Npun_R6513 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 693 0 GO:0003924; GO:0005525; GO:0005886; GO:0008289; GO:0016021 0 0 0 PF00350; B3EWY9 CHOYP_LOC590125.2.7 m.33183 sp MLP_ACRMI 27.528 1068 621 38 821 1825 388 1365 1.15E-98 357 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; D8VNT0 CHOYP_LOC100882339.2.2 m.53386 sp FCNV4_CERRY 47.005 217 109 5 68 282 126 338 1.15E-55 186 FCNV4_CERRY reviewed Ryncolin-4 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; F7H9X2 CHOYP_LOC100367600.2.2 m.39017 sp TRIM2_CALJA 25.49 204 124 7 32 219 492 683 1.15E-07 55.1 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O42387 CHOYP_LOC100376500.1.1 m.36609 sp RS24_TAKRU 80.8 125 24 0 5 129 4 128 1.15E-71 213 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O43301 CHOYP_HS12A.3.33 m.21343 sp HS12A_HUMAN 33.384 656 341 18 8 604 56 674 1.15E-95 310 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O60494 CHOYP_ISCW_ISCW023296.1.1 m.59066 sp CUBN_HUMAN 20.833 552 369 19 20 529 1161 1686 1.15E-11 72.4 CUBN_HUMAN reviewed Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) 3623 cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; tissue homeostasis [GO:0001894]; vitamin D metabolic process [GO:0042359] GO:0001894; GO:0004872; GO:0005215; GO:0005509; GO:0005765; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0005905; GO:0006898; GO:0008203; GO:0009235; GO:0010008; GO:0015031; GO:0015889; GO:0016020; GO:0016324; GO:0030139; GO:0031232; GO:0031419; GO:0031526; GO:0042157; GO:0042359; GO:0042803; GO:0042953; GO:0043202; GO:0070062 0 0 0 PF00431;PF00008;PF12947;PF07645; O75179 CHOYP_LOC753709.13.44 m.23565 sp ANR17_HUMAN 33.268 514 289 16 215 678 208 717 1.15E-56 213 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O88866 CHOYP_LOC100634730.1.1 m.56113 sp HUNK_MOUSE 44.411 331 178 4 41 365 56 386 1.15E-81 280 HUNK_MOUSE reviewed Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Hunk Makv Mus musculus (Mouse) 714 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0035556 0 0 0 PF00069; P02637 CHOYP_SCP.7.12 m.52093 sp SCP_MIZYE 35.714 182 103 6 19 199 2 170 1.15E-28 108 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P0C6B8 CHOYP_NEMVEDRAFT_V1G141380.3.4 m.21933 sp SVEP1_RAT 39.919 248 124 9 136 383 1192 1414 1.15E-41 160 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P10076 CHOYP_BRAFLDRAFT_72611.1.1 m.61108 sp ZFP26_MOUSE 22.594 478 293 19 462 930 363 772 1.15E-07 60.5 ZFP26_MOUSE reviewed Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) 861 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; P18433 CHOYP_PTPRT.27.45 m.52048 sp PTPRA_HUMAN 29.844 707 452 21 336 1025 121 800 1.15E-78 277 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P18503 CHOYP_BRAFLDRAFT_76550.13.21 m.58544 sp CAS4_EPHMU 33.333 120 60 4 74 190 207 309 1.15E-06 52.4 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P23469 CHOYP_PTPRA.21.22 m.61071 sp PTPRE_HUMAN 29.766 598 378 11 490 1059 115 698 1.15E-72 258 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P24049 CHOYP_RL17.5.7 m.40939 sp RL17_RAT 78.125 160 35 0 1 160 1 160 1.15E-93 272 RL17_RAT reviewed 60S ribosomal protein L17 (Amino acid starvation-induced protein) (ASI) (L23) Rpl17 Rattus norvegicus (Rat) 184 cellular response to amino acid starvation [GO:0034198]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; response to amino acid starvation [GO:1990928]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005844; GO:0006412; GO:0022625; GO:0031672; GO:0034198; GO:0070180; GO:1900087; GO:1990928 0 0 cd00336; PF00237; P24507 CHOYP_LOC100378517.1.1 m.66228 sp SY63_DIPOM 29.268 287 179 7 127 407 238 506 1.15E-30 126 SY63_DIPOM reviewed Synaptotagmin-C (Synaptic vesicle protein O-p65-C) P65-C Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) 537 calcium ion regulated exocytosis [GO:0017156] GO:0016021; GO:0017156; GO:0030054; GO:0030672; GO:0046872 0 0 0 PF00168; P30988 CHOYP_CALCR.3.6 m.22161 sp CALCR_HUMAN 25.7 393 247 14 99 474 73 437 1.15E-30 128 CALCR_HUMAN reviewed Calcitonin receptor (CT-R) CALCR Homo sapiens (Human) 508 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; response to glucocorticoid [GO:0051384] GO:0004872; GO:0004948; GO:0005623; GO:0005886; GO:0005887; GO:0007166; GO:0007189; GO:0007204; GO:0008565; GO:0015031; GO:0030819; GO:0031623; GO:0032841; GO:0045762; GO:0051384; GO:0072659 0 0 0 PF00002;PF02793; P36241 CHOYP_LOC101021639.1.1 m.58989 sp RL19_DROME 80.952 126 24 0 20 145 1 126 1.15E-70 214 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P38984 CHOYP_RSSA.3.10 m.22113 sp RSSA_HYDVD 69.805 308 78 6 24 331 1 293 1.15E-150 427 RSSA_HYDVD reviewed 40S ribosomal protein SA (33 kDa laminin-binding protein) (p40) 0 Hydra viridissima (Green hydra) (Chlorohydra viridissima) 293 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; P42674 CHOYP_LOC581452.1.4 m.20199 sp BP10_PARLI 36.882 263 146 6 66 315 67 322 1.15E-36 149 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P48809 CHOYP_AAEL_AAEL008257.1.3 m.10619 sp RB27C_DROME 50.211 237 106 5 12 241 1 232 1.15E-67 226 RB27C_DROME reviewed Heterogeneous nuclear ribonucleoprotein 27C (Hrb27-C) (HRP48.1) (hnRNP 48) Hrb27C hrp48 Rbp7 CG10377 Drosophila melanogaster (Fruit fly) 421 "axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; lateral inhibition [GO:0046331]; negative regulation of oskar mRNA translation [GO:0007319]; pole plasm oskar mRNA localization [GO:0045451]; positive regulation of translation [GO:0045727]; regulation of mRNA splicing, via spliceosome [GO:0048024]" GO:0000166; GO:0003697; GO:0003729; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0007298; GO:0007319; GO:0007411; GO:0030529; GO:0043186; GO:0043234; GO:0045451; GO:0045727; GO:0046331; GO:0048024; GO:0048027 0 0 0 PF00076; P49013 CHOYP_ISCW_ISCW012228.1.2 m.57883 sp FBP3_STRPU 56.41 78 32 1 162 239 176 251 1.15E-19 91.3 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P49165 CHOYP_ADA17.1.3 m.797 sp RL4_URECA 65.969 191 57 3 1 188 195 380 1.15E-78 242 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; P54316 CHOYP_BRAFLDRAFT_126555.4.6 m.29592 sp LIPR1_RAT 35.602 382 208 7 34 393 21 386 1.15E-70 235 LIPR1_RAT reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) Pnliprp1 Plrp1 Rattus norvegicus (Rat) 473 lipid metabolic process [GO:0006629]; pancreas development [GO:0031016]; response to glucocorticoid [GO:0051384]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005509; GO:0005615; GO:0006629; GO:0016298; GO:0031016; GO:0043434; GO:0051384 0 0 0 PF00151;PF01477; P56719 CHOYP_AAEL_AAEL010626.1.1 m.52019 sp OX2R_RAT 27.465 284 175 13 4 268 16 287 1.15E-11 70.5 OX2R_RAT reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0004930; GO:0005887; GO:0007186; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P60484 CHOYP_PTEN.1.1 m.5408 sp PTEN_HUMAN 56.836 373 143 6 1 358 1 370 1.15E-143 420 PTEN_HUMAN reviewed "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)" PTEN MMAC1 TEP1 Homo sapiens (Human) 403 "adult behavior [GO:0030534]; aging [GO:0007568]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; brain morphogenesis [GO:0048854]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue development [GO:0048738]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cellular response to hypoxia [GO:0071456]; central nervous system development [GO:0007417]; central nervous system myelin maintenance [GO:0032286]; central nervous system neuron axonogenesis [GO:0021955]; dendritic spine morphogenesis [GO:0060997]; dentate gyrus development [GO:0021542]; endothelial cell migration [GO:0043542]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; inositol phosphate dephosphorylation [GO:0046855]; inositol phosphate metabolic process [GO:0043647]; learning or memory [GO:0007611]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; long term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; male mating behavior [GO:0060179]; maternal behavior [GO:0042711]; memory [GO:0007613]; multicellular organismal response to stress [GO:0033555]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell aging [GO:0090344]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031658]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myelination [GO:0031642]; negative regulation of organ growth [GO:0046621]; negative regulation of phagocytosis [GO:0050765]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of synaptic vesicle clustering [GO:2000808]; neuron-neuron synaptic transmission [GO:0007270]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; postsynaptic density assembly [GO:0097107]; prepulse inhibition [GO:0060134]; presynaptic membrane assembly [GO:0097105]; prostate gland growth [GO:0060736]; protein dephosphorylation [GO:0006470]; protein kinase B signaling [GO:0043491]; protein stabilization [GO:0050821]; regulation of axon regeneration [GO:0048679]; regulation of B cell apoptotic process [GO:0002902]; regulation of cellular component size [GO:0032535]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of myeloid cell apoptotic process [GO:0033032]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to arsenic-containing substance [GO:0046685]; response to ATP [GO:0033198]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to nutrient [GO:0007584]; response to zinc ion [GO:0010043]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]; T cell receptor signaling pathway [GO:0050852]" GO:0000079; GO:0000287; GO:0001525; GO:0001933; GO:0002902; GO:0004438; GO:0004721; GO:0004722; GO:0004725; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006470; GO:0006661; GO:0006915; GO:0007270; GO:0007416; GO:0007417; GO:0007507; GO:0007568; GO:0007584; GO:0007611; GO:0007613; GO:0007626; GO:0008138; GO:0008283; GO:0008284; GO:0008285; GO:0008289; GO:0009749; GO:0009898; GO:0010043; GO:0010975; GO:0010997; GO:0014067; GO:0016314; GO:0016324; GO:0016477; GO:0016605; GO:0019899; GO:0021542; GO:0021955; GO:0030165; GO:0030336; GO:0030534; GO:0031642; GO:0031647; GO:0031658; GO:0032228; GO:0032286; GO:0032355; GO:0032535; GO:0033032; GO:0033198; GO:0033555; GO:0035176; GO:0035749; GO:0042493; GO:0042711; GO:0042802; GO:0042995; GO:0043005; GO:0043066; GO:0043197; GO:0043220; GO:0043491; GO:0043542; GO:0043647; GO:0045211; GO:0045471; GO:0045475; GO:0045792; GO:0046621; GO:0046685; GO:0046855; GO:0046856; GO:0048008; GO:0048015; GO:0048679; GO:0048738; GO:0048853; GO:0048854; GO:0050680; GO:0050765; GO:0050771; GO:0050821; GO:0050852; GO:0051091; GO:0051717; GO:0051800; GO:0051895; GO:0051898; GO:0060024; GO:0060070; GO:0060074; GO:0060134; GO:0060179; GO:0060291; GO:0060292; GO:0060736; GO:0060997; GO:0061002; GO:0070373; GO:0070374; GO:0071456; GO:0090071; GO:0090344; GO:0090394; GO:0097105; GO:0097107; GO:1903984; GO:1904668; GO:2000060; GO:2000134; GO:2000463; GO:2000808 0 0 0 PF00782;PF10409; P91573 CHOYP_LOC100498159.1.1 m.23845 sp WRT6_CAEEL 55.556 45 20 0 122 166 341 385 1.15E-08 57 WRT6_CAEEL reviewed Warthog protein 6 [Cleaved into: Warthog protein 6 N-product; Warthog protein 6 C-product] wrt-6 ZK377.1 Caenorhabditis elegans 593 cell-cell signaling [GO:0007267]; intein-mediated protein splicing [GO:0016539]; multicellular organism development [GO:0007275] GO:0005615; GO:0005886; GO:0007267; GO:0007275; GO:0008233; GO:0009986; GO:0016539 0 0 0 PF01079; P91943 CHOYP_PANG1.2.2 m.57900 sp PANG1_DROME 51.89 291 110 11 92 365 112 389 1.15E-73 246 PANG1_DROME reviewed "Protein pangolin, isoforms A/H/I/S (dTCF)" pan TCF CG34403 Drosophila melanogaster (Fruit fly) 751 "embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; imaginal disc-derived wing morphogenesis [GO:0007476]; mesodermal cell fate determination [GO:0007500]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of hemocyte differentiation [GO:0045610]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription, DNA-templated [GO:0006355]; regulation of Wnt signaling pathway [GO:0030111]; salivary gland morphogenesis [GO:0007435]; segment polarity determination [GO:0007367]; spiracle morphogenesis, open tracheal system [GO:0035277]; transcription from RNA polymerase II promoter [GO:0006366]; Wnt signaling pathway [GO:0016055]" GO:0003705; GO:0005634; GO:0005667; GO:0005875; GO:0006355; GO:0006366; GO:0007367; GO:0007435; GO:0007476; GO:0007500; GO:0007507; GO:0009880; GO:0010628; GO:0016055; GO:0019900; GO:0030111; GO:0030178; GO:0035277; GO:0043565; GO:0045610; GO:0045892; GO:0045893; GO:0045944; GO:0070491; GO:0072091 0 0 0 PF08347;PF00505; P9WK87 CHOYP_LOC100371983.3.3 m.66662 sp NLHH_MYCTU 34 150 95 3 57 206 51 196 1.15E-16 80.1 NLHH_MYCTU reviewed Carboxylesterase NlhH (EC 3.1.1.1) nlhH lipH Rv1399c Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 319 catabolic process [GO:0009056] GO:0009056; GO:0034338 0 0 0 PF07859; Q03923 CHOYP_ZN235.1.1 m.12009 sp ZNF85_HUMAN 44.758 248 120 5 5 250 352 584 1.15E-58 199 ZNF85_HUMAN reviewed Zinc finger protein 85 (Zinc finger protein HPF4) (Zinc finger protein HTF1) ZNF85 Homo sapiens (Human) 595 "transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003677; GO:0003700; GO:0003714; GO:0005634; GO:0006351; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q05609 CHOYP_CTR1.4.4 m.56586 sp CTR1_ARATH 35.922 309 176 10 520 823 514 805 1.15E-39 161 CTR1_ARATH reviewed Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1) CTR1 At5g03730 F17C15_150 Arabidopsis thaliana (Mouse-ear cress) 821 cellular response to iron ion [GO:0071281]; ethylene-activated signaling pathway [GO:0009873]; gibberellin biosynthetic process [GO:0009686]; negative regulation of ethylene-activated signaling pathway [GO:0010105]; protein autophosphorylation [GO:0046777]; regulation of post-embryonic root development [GO:2000069]; regulation of stem cell division [GO:2000035]; regulation of timing of transition from vegetative to reproductive phase [GO:0048510]; response to ethylene [GO:0009723]; response to fructose [GO:0009750]; response to hypoxia [GO:0001666]; response to sucrose [GO:0009744]; sugar mediated signaling pathway [GO:0010182] GO:0001666; GO:0004674; GO:0004712; GO:0005524; GO:0005789; GO:0009686; GO:0009723; GO:0009744; GO:0009750; GO:0009873; GO:0010105; GO:0010182; GO:0046777; GO:0048510; GO:0071281; GO:2000035; GO:2000069 0 0 0 PF07714; Q06649 CHOYP_LOC100539968.1.1 m.51646 sp 3BP2_MOUSE 29.63 135 78 3 17 150 11 129 1.15E-10 66.2 3BP2_MOUSE reviewed SH3 domain-binding protein 2 (3BP-2) Sh3bp2 3bp2 Mus musculus (Mouse) 559 0 GO:0017124 0 0 0 PF00169;PF00017; Q08CA1 CHOYP_LOC100367014.1.1 m.18505 sp GDPP1_DANRE 45.69 348 167 6 5 343 7 341 1.15E-100 303 GDPP1_DANRE reviewed GDP-D-glucose phosphorylase 1 (EC 2.7.7.78) gdpgp1 zgc:153343 Danio rerio (Zebrafish) (Brachydanio rerio) 343 glucose metabolic process [GO:0006006] GO:0000166; GO:0005085; GO:0005737; GO:0006006; GO:0016779; GO:0016787; GO:0080048 0 0 0 0 Q14162 CHOYP_MEGF6A.2.2 m.25116 sp SREC_HUMAN 41.129 124 67 4 181 303 298 416 1.15E-14 78.2 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q14318 CHOYP_LOC100378510.1.1 m.9865 sp FKBP8_HUMAN 41.956 317 173 7 180 487 93 407 1.15E-71 236 FKBP8_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) FKBP8 FKBP38 Homo sapiens (Human) 412 apoptotic process [GO:0006915]; camera-type eye development [GO:0043010]; cell fate specification [GO:0001708]; chaperone-mediated protein folding [GO:0061077]; dorsal/ventral neural tube patterning [GO:0021904]; intracellular signal transduction [GO:0035556]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; positive regulation of BMP signaling pathway [GO:0030513]; smoothened signaling pathway [GO:0007224]; viral process [GO:0016032] GO:0001708; GO:0003755; GO:0005528; GO:0005789; GO:0006915; GO:0007224; GO:0016020; GO:0016032; GO:0021904; GO:0030176; GO:0030513; GO:0031966; GO:0035264; GO:0035556; GO:0042802; GO:0043010; GO:0043066; GO:0046872; GO:0061077 0 0 0 PF00254;PF07719; Q17QR8 CHOYP_LOC588039.4.6 m.43083 sp HARB1_BOVIN 47.959 98 51 0 2 99 212 309 1.15E-25 102 HARB1_BOVIN reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 Bos taurus (Bovine) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0005813; GO:0046872 0 0 0 PF13359; Q2HJ10 CHOYP_LOC100891808.1.1 m.24065 sp ZNT2_MOUSE 41.005 378 162 6 187 559 48 369 1.15E-86 276 ZNT2_MOUSE reviewed Zinc transporter 2 (ZnT-2) (Solute carrier family 30 member 2) Slc30a2 Znt2 Mus musculus (Mouse) 371 positive regulation of sequestering of zinc ion [GO:0061090]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043] GO:0005385; GO:0005737; GO:0005765; GO:0005770; GO:0005886; GO:0010043; GO:0016021; GO:0016023; GO:0061088; GO:0061090 0 0 0 PF01545; Q3URR7 CHOYP_ZSCAN22.1.1 m.53170 sp ZSC10_MOUSE 32.85 207 121 7 115 308 576 777 1.15E-20 98.2 ZSC10_MOUSE reviewed Zinc finger and SCAN domain-containing protein 10 (Zinc finger protein 206) Zscan10 Zfp206 Mus musculus (Mouse) 782 "negative regulation of transcription, DNA-templated [GO:0045892]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0045892; GO:0046872; GO:0048863 0 0 0 PF02023;PF00096; Q3ZCI8 CHOYP_AAEL_AAEL006632.1.1 m.2010 sp REEP4_BOVIN 46.502 243 118 6 32 267 1 238 1.15E-62 201 REEP4_BOVIN reviewed Receptor expression-enhancing protein 4 REEP4 Bos taurus (Bovine) 257 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope reassembly [GO:0007084]; nuclear envelope organization [GO:0006998] GO:0005783; GO:0005789; GO:0005874; GO:0006998; GO:0007067; GO:0007084; GO:0008017; GO:0016021; GO:0051301 0 0 0 PF03134; Q5M8Z2 CHOYP_LOC100374685.1.1 m.16061 sp PREY_XENTR 59.155 71 27 1 27 97 48 116 1.15E-22 87.8 PREY_XENTR reviewed "Protein preY, mitochondrial" pyurf pigy prey Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 122 0 GO:0005739 0 0 0 PF03966; Q5NVN8 CHOYP_LOC100725472.2.2 m.44906 sp RFOX1_PONAB 57.333 75 28 2 132 203 83 156 1.15E-18 88.2 RFOX1_PONAB reviewed RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) RBFOX1 A2BP1 FOX1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 382 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0008380; GO:0043484 0 0 0 PF12414;PF00076; Q5QJC4 CHOYP_DCLRE1A.2.2 m.30762 sp DCR1A_CHICK 32.121 165 79 5 5 140 8 168 1.15E-19 87 DCR1A_CHICK reviewed DNA cross-link repair 1A protein (SNM1 homolog A) (chSNM1A) DCLRE1A SNM1A Gallus gallus (Chicken) 972 "DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; protection from non-homologous end joining at telomere [GO:0031848]" GO:0000715; GO:0000784; GO:0003684; GO:0005654; GO:0006281; GO:0006303; GO:0031848; GO:0035312; GO:0036297 0 0 0 PF07522; Q5R462 CHOYP_TSAP1.2.2 m.63951 sp TSAP1_PONAB 49.254 67 34 0 1 67 10 76 1.15E-18 82.4 TSAP1_PONAB reviewed tRNA selenocysteine 1-associated protein 1 (tRNA selenocysteine-associated protein 1) TRNAU1AP TRSPAP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 287 translation [GO:0006412] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006412 0 0 0 PF00076; Q5R939 CHOYP_FAM204A.1.1 m.9252 sp F204A_PONAB 42.609 115 65 1 134 247 112 226 1.15E-19 87.8 F204A_PONAB reviewed Protein FAM204A FAM204A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 233 0 0 0 0 0 0 Q5TC84 CHOYP_BRAFLDRAFT_83521.1.1 m.2242 sp OGRL1_HUMAN 38.191 199 114 3 12 205 190 384 1.15E-34 133 OGRL1_HUMAN reviewed Opioid growth factor receptor-like protein 1 OGFRL1 Homo sapiens (Human) 451 0 GO:0004872; GO:0016020 0 0 0 PF04664; Q5UR67 CHOYP_contig_042078 m.48331 sp RIBX_MIMIV 37.654 162 90 3 343 493 6 167 1.15E-23 100 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5XGI1 CHOYP_UCP5.1.1 m.57638 sp KMCP1_XENTR 61.135 229 84 2 3 229 5 230 1.15E-96 287 KMCP1_XENTR reviewed Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) slc25a30 kmcp1 TGas086a12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 291 mitochondrial transport [GO:0006839]; translation [GO:0006412] GO:0003735; GO:0005743; GO:0006412; GO:0006839; GO:0016021 0 0 0 PF00153; Q60902 CHOYP_AAEL_AAEL007950.1.1 m.15805 sp EP15R_MOUSE 54.545 99 44 1 8 106 6 103 1.15E-26 106 EP15R_MOUSE reviewed Epidermal growth factor receptor substrate 15-like 1 (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs) (Eps15-related protein) (Eps15R) Eps15l1 Eps15-rs Eps15R Mus musculus (Mouse) 907 endocytosis [GO:0006897] GO:0005509; GO:0005634; GO:0006897; GO:0016020; GO:0030132 0 0 0 PF12763; Q63184 CHOYP_LOC100208179.1.3 m.27335 sp E2AK2_RAT 31.988 322 164 9 42 361 220 488 1.15E-36 144 E2AK2_RAT reviewed "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2)" Eif2ak2 Prkr Rattus norvegicus (Rat) 513 "activation of MAPKK activity [GO:0000186]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to exogenous dsRNA [GO:0043330]; response to interferon-alpha [GO:0035455]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to organic substance [GO:0010033]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to vitamin E [GO:0033197]; transcription, DNA-templated [GO:0006351]" GO:0000186; GO:0001819; GO:0003725; GO:0004672; GO:0004674; GO:0004715; GO:0005524; GO:0005634; GO:0005737; GO:0006351; GO:0006468; GO:0009612; GO:0009615; GO:0009636; GO:0010033; GO:0010998; GO:0017148; GO:0032496; GO:0032722; GO:0032874; GO:0033197; GO:0033689; GO:0035455; GO:0043065; GO:0043330; GO:0045071; GO:0045087; GO:0046777; GO:0048471; GO:0051092; GO:0051607; GO:1900225; GO:1901224; GO:1901532; GO:1902033; GO:1902036 0 0 0 PF00035;PF00069; Q63HM9 CHOYP_LOC100496710.1.1 m.12836 sp PLCX3_HUMAN 39.667 300 179 1 36 333 13 312 1.15E-80 251 PLCX3_HUMAN reviewed PI-PLC X domain-containing protein 3 PLCXD3 Homo sapiens (Human) 321 lipid catabolic process [GO:0016042] GO:0004871; GO:0008081; GO:0016042 0 0 0 0 Q640V9 CHOYP_LOC580466.1.2 m.18704 sp TATD1_XENLA 63.851 296 105 1 10 305 2 295 1.15E-141 404 TATD1_XENLA reviewed Putative deoxyribonuclease TATDN1 (EC 3.1.21.-) tatdn1 Xenopus laevis (African clawed frog) 297 0 GO:0005634; GO:0016888; GO:0046872 0 0 0 PF01026; Q66II8 CHOYP_LOC662320.1.2 m.18374 sp RU17_XENTR 69.124 217 66 1 1 216 1 217 1.15E-77 245 RU17_XENTR reviewed U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) snrnp70 snrp70 TNeu055c14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 471 "hematopoietic stem cell differentiation [GO:0060218]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]" GO:0000166; GO:0000243; GO:0000398; GO:0003723; GO:0003729; GO:0005681; GO:0005685; GO:0016607; GO:0030619; GO:0043484; GO:0060218; GO:0071004; GO:0071011 0 0 0 PF00076;PF12220; Q6DFC6 CHOYP_WDR75.1.1 m.9234 sp WDR75_XENLA 35.431 858 493 21 5 832 6 832 1.15E-153 473 WDR75_XENLA reviewed WD repeat-containing protein 75 wdr75 Xenopus laevis (African clawed frog) 832 0 GO:0005730 0 0 0 PF00400; Q6GQ69 CHOYP_FAF2A.1.1 m.27947 sp FAF2B_XENLA 53.043 460 187 8 15 464 1 441 1.15E-170 490 FAF2B_XENLA reviewed FAS-associated factor 2-B (UBX domain-containing protein 8-B) faf2-b ubxd8-b Xenopus laevis (African clawed frog) 445 0 GO:0005783; GO:0005811 0 0 0 PF00789; Q6ZV89 CHOYP_SMP_105540.1.1 m.40275 sp SH2D5_HUMAN 40.496 121 72 0 89 209 26 146 1.15E-22 105 SH2D5_HUMAN reviewed SH2 domain-containing protein 5 SH2D5 Homo sapiens (Human) 423 0 GO:0014069; GO:0030054; GO:0045211 0 0 0 0 Q7LHG5 CHOYP_contig_006919 m.7907 sp YI31B_YEAST 34.701 902 513 23 35 927 616 1450 1.15E-139 461 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q7M456 CHOYP_DPSE_GA20886.2.2 m.39029 sp RNOY_CRAGI 37.805 82 44 4 16 91 25 105 1.15E-11 61.2 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q80WQ8 CHOYP_M18BP.2.2 m.48077 sp M18BP_MOUSE 28.626 262 152 12 50 288 746 995 1.15E-18 89.7 M18BP_MOUSE reviewed Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) Mis18bp1 Kiaa1903 Knl2 M18bp1 Mus musculus (Mouse) 998 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0000778; GO:0003677; GO:0007067; GO:0051301 0 0 0 PF00249;PF09133; Q8IWZ3 CHOYP_LOC100641396.15.27 m.41987 sp ANKH1_HUMAN 32.297 418 260 14 52 449 246 660 1.15E-43 168 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8L970 CHOYP_BRAFLDRAFT_67911.1.1 m.4174 sp P4H7_ARATH 28.75 240 111 7 251 469 64 264 1.15E-16 84.3 P4H7_ARATH reviewed Probable prolyl 4-hydroxylase 7 (AtP4H7) (EC 1.14.11.2) P4H7 At3g28480 MFJ20.17 Arabidopsis thaliana (Mouse-ear cress) 316 0 GO:0004656; GO:0005506; GO:0005789; GO:0016021; GO:0031418 0 0 0 PF13640;PF01549; Q8UVR8 CHOYP_CSF12.1.1 m.5867 sp CSF12_TAKRU 26.712 146 99 2 2 147 840 977 1.15E-11 66.2 CSF12_TAKRU reviewed Macrophage colony-stimulating factor 1 receptor 2 (CSF-1-R 2) (EC 2.7.10.1) csf1r2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 1019 cytokine-mediated signaling pathway [GO:0019221]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0005886; GO:0006954; GO:0007169; GO:0016021; GO:0019221; GO:0045087 0 0 0 PF07714; Q8VXZ0 CHOYP_LOC100707656.1.1 m.10569 sp NUD20_ARATH 36.713 286 167 3 15 290 77 358 1.15E-54 185 NUD20_ARATH reviewed "Nudix hydrolase 20, chloroplastic (AtNUDT20) (EC 3.6.1.-)" NUDT20 NUDX20 At5g19460 F7K24.210 Arabidopsis thaliana (Mouse-ear cress) 374 0 GO:0009507; GO:0044715; GO:0046872 0 0 0 PF15916;PF00293; Q8WQA4 CHOYP_DWIL_GK25045.2.2 m.11828 sp EXC4_CAEEL 31.449 283 154 8 50 308 8 274 1.15E-31 123 EXC4_CAEEL reviewed Chloride intracellular channel exc-4 (Excretory canal abnormal protein 4) exc-4 Y105E8A.22 Caenorhabditis elegans 290 chloride transmembrane transport [GO:1902476]; epithelial cell development [GO:0002064]; regulation of tube size [GO:0035150] GO:0002064; GO:0005244; GO:0005254; GO:0005634; GO:0005764; GO:0005887; GO:0016324; GO:0034707; GO:0035150; GO:0043296; GO:1902476 0 0 0 0 Q90252 CHOYP_LOC100367563.1.1 m.33811 sp MTR_RHIMB 33.557 298 162 11 40 323 61 336 1.15E-39 147 MTR_RHIMB reviewed Mesotocin receptor (MTR) 0 Rhinella marina (Cane toad) (Bufo marinus) 389 0 GO:0004990; GO:0005000; GO:0005886; GO:0016021 0 0 0 PF00001; Q98943 CHOYP_BRAFLDRAFT_86694.3.3 m.53425 sp CASP2_CHICK 34.259 108 71 0 847 954 3 110 1.15E-09 65.5 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q99PP7 CHOYP_TIF1A.7.8 m.49964 sp TRI33_MOUSE 22.635 296 193 10 19 293 131 411 1.15E-09 62.8 TRI33_MOUSE reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Trim33 Kiaa1113 Mus musculus (Mouse) 1142 "negative regulation of BMP signaling pathway [GO:0030514]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q9BMX5 CHOYP_RS6.12.12 m.57885 sp RS6_APLCA 80 130 21 2 14 138 117 246 1.15E-62 194 RS6_APLCA reviewed 40S ribosomal protein S6 RPS6 Aplysia californica (California sea hare) 247 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01092; Q9BRZ2 CHOYP_SRAP.14.18 m.50950 sp TRI56_HUMAN 30.182 275 156 5 7 263 10 266 1.15E-33 144 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9BU19 CHOYP_LOC101060411.1.1 m.54762 sp ZN692_HUMAN 45.098 51 28 0 52 102 11 61 1.15E-07 56.2 ZN692_HUMAN reviewed Zinc finger protein 692 ZNF692 Homo sapiens (Human) 519 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q9CX00 CHOYP_LOC100115002.1.1 m.45844 sp IST1_MOUSE 49.344 381 154 11 1 362 1 361 1.15E-102 310 IST1_MOUSE reviewed IST1 homolog Ist1 Kiaa0174 Mus musculus (Mouse) 362 abscission [GO:0009838]; cell division [GO:0051301]; cytokinesis [GO:0000910]; establishment of protein localization [GO:0045184]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of proteolysis [GO:0045862]; protein localization [GO:0008104]; protein transport [GO:0015031]; viral capsid secondary envelopment [GO:0046745]; viral release from host cell [GO:0019076]; xenophagy [GO:0098792] GO:0000910; GO:0002230; GO:0005635; GO:0005793; GO:0005813; GO:0005829; GO:0008104; GO:0009838; GO:0015031; GO:0016023; GO:0019076; GO:0019904; GO:0030496; GO:0032403; GO:0045184; GO:0045862; GO:0046745; GO:0048672; GO:0051301; GO:0070062; GO:0090541; GO:0090543; GO:0098779; GO:0098792 0 0 0 PF03398; Q9D032 CHOYP_SSDP.1.1 m.47615 sp SSBP3_MOUSE 62.284 289 69 14 10 285 1 262 1.15E-81 260 SSBP3_MOUSE reviewed Single-stranded DNA-binding protein 3 (Lck-associated signal transducer) (Sequence-specific single-stranded-DNA-binding protein) Ssbp3 Last Ssdp1 Mus musculus (Mouse) 388 "head development [GO:0060322]; head morphogenesis [GO:0060323]; hematopoietic progenitor cell differentiation [GO:0002244]; midbrain-hindbrain boundary initiation [GO:0021547]; positive regulation of anterior head development [GO:2000744]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; prechordal plate formation [GO:0021501]; protein complex assembly [GO:0006461]; transcription, DNA-templated [GO:0006351]" GO:0002244; GO:0003697; GO:0005634; GO:0006351; GO:0006461; GO:0008284; GO:0021501; GO:0021547; GO:0043234; GO:0045893; GO:0045944; GO:0060322; GO:0060323; GO:2000744 0 0 0 0 Q9D9R9 CHOYP_contig_024585 m.27945 sp F186A_MOUSE 36.648 352 145 19 104 401 590 917 1.15E-12 73.9 F186A_MOUSE reviewed Protein FAM186A FAM186A Gm920 Mus musculus (Mouse) 1790 0 0 0 0 0 0 Q9DBB9 CHOYP_CPN2.1.1 m.54472 sp CPN2_MOUSE 31.785 409 265 9 10 411 10 411 1.15E-36 147 CPN2_MOUSE reviewed Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) Cpn2 Mus musculus (Mouse) 547 0 GO:0070062; GO:0072562 0 0 0 PF13855; Q9DC07 CHOYP_LNEBL.1.1 m.41145 sp LNEBL_MOUSE 58.156 141 57 2 1 139 1 141 1.15E-56 180 LNEBL_MOUSE reviewed LIM zinc-binding domain-containing Nebulette (Actin-binding Z-disk protein) Nebl Lnebl Mus musculus (Mouse) 270 0 GO:0005737; GO:0008270 0 0 0 PF00412;PF00880;PF14604; Q9H0J9 CHOYP_BRAFLDRAFT_92020.2.3 m.53208 sp PAR12_HUMAN 28.528 652 354 24 102 704 89 677 1.15E-60 220 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9I9A7 CHOYP_LOC100376797.1.1 m.19305 sp CDT1_XENLA 45.889 377 186 5 353 718 238 607 1.15E-108 346 CDT1_XENLA reviewed DNA replication factor Cdt1 (XCDT1) cdt1 Xenopus laevis (African clawed frog) 617 cell cycle [GO:0007049]; DNA replication [GO:0006260] GO:0003677; GO:0005634; GO:0006260; GO:0007049 0 0 0 PF08839;PF16679; Q9JKL7 CHOYP_LOC100370236.3.3 m.40682 sp SREK1_RAT 57.333 150 63 1 136 284 41 190 1.15E-51 189 SREK1_RAT reviewed "Splicing regulatory glutamine/lysine-rich protein 1 (SR-related protein of 86 kDa) (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12)" Srek1 Sfrs12 Srrp86 Rattus norvegicus (Rat) 494 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003676; GO:0005681; GO:0006397; GO:0008380 0 0 0 PF00076; Q9N295 CHOYP_LOC100878226.1.1 m.2025 sp B3GT5_PANTR 33.333 237 142 6 84 315 32 257 1.15E-38 142 B3GT5_PANTR reviewed "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5) (Fragment)" B3GALT5 Pan troglodytes (Chimpanzee) 297 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9NLA3 CHOYP_ANO39.1.1 m.15713 sp ANO39_PATPE 42.857 56 32 0 1 56 63 118 1.15E-07 52.4 ANO39_PATPE reviewed Nucleoplasmin-like protein ANO39 (39 kDa oocyte-expressed nucleolar protein) (Nucleic acid-associated protein 36) (Nucleic acid-binding nuclear protein) (NAAP) (NAAP1) (NAAP2) 0 Patiria pectinifera (Starfish) (Asterina pectinifera) 346 mitotic nuclear division [GO:0007067]; oocyte maturation [GO:0001556] GO:0001556; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007067 0 0 0 PF16276;PF03066; Q9P2N4 CHOYP_BRAFLDRAFT_67741.1.2 m.5311 sp ATS9_HUMAN 25.121 207 122 9 224 411 1735 1927 1.15E-07 58.2 ATS9_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) 1935 glycoprotein catabolic process [GO:0006516]; multicellular organism development [GO:0007275]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; vesicle-mediated transport [GO:0016192] GO:0004222; GO:0005578; GO:0005615; GO:0005783; GO:0006508; GO:0006516; GO:0007275; GO:0008237; GO:0008270; GO:0009986; GO:0015031; GO:0016192; GO:0045636 0 0 0 PF05986;PF08685;PF01562;PF01421;PF00090; Q9QUN3 CHOYP_PHUM_PHUM128460.6.7 m.60989 sp BLNK_MOUSE 34.513 113 70 3 552 661 342 453 1.15E-14 80.5 BLNK_MOUSE reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) Blnk Bash Ly57 Slp65 Mus musculus (Mouse) 457 B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005737; GO:0005886; GO:0006955; GO:0035556; GO:0042113 0 0 0 PF00017; Q9R1R2 CHOYP_BRAFLDRAFT_85511.4.23 m.17382 sp TRIM3_MOUSE 22.5 280 166 13 303 555 489 744 1.15E-07 58.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U489 CHOYP_BRAFLDRAFT_87325.11.11 m.65071 sp LIN41_CAEEL 26.012 173 101 6 3 162 848 1006 1.15E-07 53.9 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9UGM3 CHOYP_BRAFLDRAFT_230523.3.3 m.63027 sp DMBT1_HUMAN 46.586 249 125 3 258 500 455 701 1.15E-57 210 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9V5L3 CHOYP_BRAFLDRAFT_91870.2.3 m.38007 sp C49A1_DROME 28.843 527 328 15 11 505 48 559 1.15E-55 199 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q9WVT6 CHOYP_LOC100728292.1.1 m.10304 sp CAH14_MOUSE 41.549 284 158 6 26 305 2 281 1.15E-69 223 CAH14_MOUSE reviewed Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) Ca14 Car14 Catm Mus musculus (Mouse) 337 carbon dioxide transport [GO:0015670]; regulation of pH [GO:0006885] GO:0004089; GO:0006885; GO:0015670; GO:0016021; GO:0046872 0 0 0 PF00194; A2ASS6 CHOYP_LOC100367237.2.2 m.47349 sp TITIN_MOUSE 23.385 2446 1472 95 655 2912 14253 16484 1.16E-87 327 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A4IIY1 CHOYP_RN19A.1.1 m.35894 sp R144A_XENTR 30.769 169 96 6 164 325 62 216 1.16E-09 62 R144A_XENTR reviewed Probable E3 ubiquitin-protein ligase RNF144A (EC 6.3.2.-) (RING finger protein 144A) rnf144a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 292 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005794; GO:0008270; GO:0016021; GO:0016874; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; A7XYI6 CHOYP_SOBP.1.1 m.43374 sp SOBP_RAT 37.282 287 125 10 37 274 30 310 1.16E-44 176 SOBP_RAT reviewed Sine oculis-binding protein homolog (Jackson circler protein 1) Sobp Jxc1 Rattus norvegicus (Rat) 864 cochlea development [GO:0090102]; cognition [GO:0050890]; inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0005634; GO:0007605; GO:0007626; GO:0042472; GO:0046872; GO:0050890; GO:0090102 0 0 0 PF15279; A8IW99 CHOYP_LOC100369067.1.1 m.12840 sp PLD6_CHLRE 44.848 165 90 1 51 214 59 223 1.16E-50 167 PLD6_CHLRE reviewed Mitochondrial cardiolipin hydrolase (EC 3.1.-.-) (Phospholipase D6 homolog) (PLD 6) CHLREDRAFT_190403 Chlamydomonas reinhardtii (Chlamydomonas smithii) 223 cardiolipin biosynthetic process [GO:0032049]; lipid catabolic process [GO:0016042]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0004519; GO:0005739; GO:0008808; GO:0016020; GO:0016021; GO:0016042; GO:0032049; GO:0034587; GO:0046872; GO:0051321 0 0 0 PF13091; B3EWZ3 CHOYP_BRAFLDRAFT_118067.2.2 m.30722 sp CADN_ACRMI 48.739 119 57 3 516 633 456 571 1.16E-27 124 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; B3EWZ5 CHOYP_SCR-C.1.1 m.41837 sp MLRP1_ACRMI 44.444 162 79 5 136 292 927 1082 1.16E-31 135 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D3YXG0 CHOYP_BRAFLDRAFT_88566.4.11 m.5683 sp HMCN1_MOUSE 45.665 346 188 0 31 376 4522 4867 1.16E-96 326 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O08590 CHOYP_BRAFLDRAFT_217424.2.2 m.44576 sp AOC3_RAT 27.679 672 427 17 251 906 92 720 1.16E-68 247 AOC3_RAT reviewed Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (Semicarbazide-sensitive amine oxidase) (SSAO) (VP97) (Vascular adhesion protein 1) (VAP-1) Aoc3 Rattus norvegicus (Rat) 763 aging [GO:0007568]; amine metabolic process [GO:0009308]; cell adhesion [GO:0007155]; eating behavior [GO:0042755]; leukocyte migration involved in inflammatory response [GO:0002523]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of glucose transport [GO:0010828]; positive regulation of leukocyte migration [GO:0002687]; regulation of blood pressure [GO:0008217]; response to immobilization stress [GO:0035902] GO:0002523; GO:0002675; GO:0002687; GO:0005507; GO:0005615; GO:0005886; GO:0007155; GO:0007568; GO:0008131; GO:0008217; GO:0009308; GO:0009986; GO:0010828; GO:0016021; GO:0035902; GO:0042755; GO:0042803; GO:0043231; GO:0048038; GO:0052593; GO:0052594; GO:0052595; GO:0052596 0 0 0 PF01179;PF02727;PF02728; O15145 CHOYP_ARPC3.1.1 m.4439 sp ARPC3_HUMAN 72.34 141 38 1 1 140 1 141 1.16E-75 225 ARPC3_HUMAN reviewed Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) ARPC3 ARC21 Homo sapiens (Human) 178 Arp2/3 complex-mediated actin nucleation [GO:0034314]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; movement of cell or subcellular component [GO:0006928] GO:0005200; GO:0005829; GO:0005885; GO:0005925; GO:0006928; GO:0015629; GO:0016020; GO:0030027; GO:0034314; GO:0038096; GO:0048013; GO:0070062 0 0 0 PF04062; O43247 CHOYP_BRAFLDRAFT_117365.2.2 m.31681 sp TEX33_HUMAN 27.315 216 138 6 189 395 74 279 1.16E-12 71.2 TEX33_HUMAN reviewed Testis-expressed sequence 33 protein TEX33 C22orf33 EAN57 Homo sapiens (Human) 280 0 0 0 0 0 PF15400; O55203 CHOYP_LOC657473.1.1 m.55374 sp LDB2_MOUSE 68.156 358 103 5 20 370 20 373 1.16E-177 501 LDB2_MOUSE reviewed LIM domain-binding protein 2 (LDB-2) (Carboxyl-terminal LIM domain-binding protein 1) (CLIM-1) (LIM domain-binding factor CLIM1) Ldb2 Clim1 Mus musculus (Mouse) 373 epithelial structure maintenance [GO:0010669]; hair follicle development [GO:0001942]; positive regulation of cellular component biogenesis [GO:0044089]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of kinase activity [GO:0043549]; somatic stem cell population maintenance [GO:0035019] GO:0000989; GO:0001942; GO:0005634; GO:0005667; GO:0010669; GO:0019899; GO:0030274; GO:0030334; GO:0031252; GO:0035019; GO:0043549; GO:0044089; GO:0045944 0 0 0 0 O61231 CHOYP_UBCD2.1.1 m.54557 sp RL10_DROME 78.919 185 39 0 39 223 30 214 1.16E-107 311 RL10_DROME reviewed 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0043025; GO:0051297; GO:0051298 0 0 cd01433; PF00252; O75382 CHOYP_BRAFLDRAFT_89047.1.1 m.60542 sp TRIM3_HUMAN 24.82 278 164 12 13 266 486 742 1.16E-06 52.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O77302 CHOYP_PROM1.3.3 m.58805 sp RS10_LUMRU 76.923 156 28 2 1 153 1 151 1.16E-80 238 RS10_LUMRU reviewed 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) 156 0 GO:0005840 0 0 0 PF03501; O77302 CHOYP_RL7.2.2 m.57460 sp RS10_LUMRU 76.923 156 28 2 1 153 1 151 1.16E-80 238 RS10_LUMRU reviewed 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) 156 0 GO:0005840 0 0 0 PF03501; O94901 CHOYP_SUN1.1.2 m.47228 sp SUN1_HUMAN 38.786 379 202 9 521 887 452 812 1.16E-73 261 SUN1_HUMAN reviewed SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) SUN1 KIAA0810 UNC84A Homo sapiens (Human) 812 cytoskeletal anchoring at nuclear membrane [GO:0090286]; nuclear envelope organization [GO:0006998]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; ossification [GO:0001503]; response to mechanical stimulus [GO:0009612]; synapsis [GO:0007129] GO:0001503; GO:0002080; GO:0005635; GO:0005639; GO:0006998; GO:0007129; GO:0009612; GO:0031965; GO:0034993; GO:0043231; GO:0090286; GO:0090292 0 0 0 PF09387;PF07738; P02362 CHOYP_RS7.6.9 m.44704 sp RS7_XENLA 84.021 194 29 2 206 397 1 194 1.16E-113 333 RS7_XENLA reviewed 40S ribosomal protein S7 (40S ribosomal protein S8) rps7 rps8 Xenopus laevis (African clawed frog) 194 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01251; P05450 CHOYP_BRAFLDRAFT_67193.3.3 m.40896 sp YAT7_RHOBL 33.333 90 56 2 88 177 19 104 1.16E-09 56.6 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P10746 CHOYP_UROS.1.1 m.58852 sp HEM4_HUMAN 35.472 265 148 8 9 260 3 257 1.16E-41 146 HEM4_HUMAN reviewed Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) UROS Homo sapiens (Human) 265 cellular response to amine stimulus [GO:0071418]; cellular response to arsenic-containing substance [GO:0071243]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to antibiotic [GO:0046677]; uroporphyrinogen III biosynthetic process [GO:0006780] GO:0004852; GO:0005739; GO:0005829; GO:0006780; GO:0006782; GO:0006783; GO:0046677; GO:0048037; GO:0071243; GO:0071418 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4. 0 cd06578; PF02602; P16157 CHOYP_LOC581927.11.27 m.33103 sp ANK1_HUMAN 26.6 797 496 32 247 981 14 783 1.16E-40 167 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_020440.14.21 m.33137 sp ANK1_HUMAN 33.585 265 157 3 718 982 282 527 1.16E-32 141 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17178 CHOYP_BRAFLDRAFT_91870.3.3 m.62762 sp CP27A_RAT 26.305 498 334 10 58 539 52 532 1.16E-49 182 CP27A_RAT reviewed "Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)" Cyp27a1 Cyp27 Rattus norvegicus (Rat) 533 cholesterol metabolic process [GO:0008203]; steroid catabolic process [GO:0006706] GO:0005506; GO:0005739; GO:0005740; GO:0006706; GO:0008203; GO:0016705; GO:0020037; GO:0030343; GO:0031073; GO:0031966 PATHWAY: Hormone biosynthesis; cholecalciferol biosynthesis. 0 0 PF00067; P20825 CHOYP_LOC579970.2.5 m.13341 sp POL2_DROME 44.237 321 173 4 1 320 335 650 1.16E-73 265 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P21783 CHOYP_NOTCH1.1.1 m.37341 sp NOTC1_XENLA 41.176 136 76 3 88 222 834 966 1.16E-19 94 NOTC1_XENLA reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (xOTCH) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 xotch Xenopus laevis (African clawed frog) 2524 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001525; GO:0004872; GO:0005509; GO:0005654; GO:0005886; GO:0006351; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P24733 CHOYP_MYS.1.7 m.438 sp MYS_ARGIR 64.444 90 28 1 1 90 1808 1893 1.16E-27 112 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P28662 CHOYP_LOC100375457.1.1 m.54750 sp BRI3_MOUSE 53.165 79 36 1 67 144 47 125 1.16E-23 92 BRI3_MOUSE reviewed Brain protein I3 Bri3 Mus musculus (Mouse) 125 0 GO:0016021; GO:0042802 0 0 0 PF10164; P30974 CHOYP_NPR15.2.2 m.43501 sp TLR1_DROME 26.552 290 173 9 3 275 116 382 1.16E-27 114 TLR1_DROME reviewed Tachykinin-like peptides receptor 86C (NKD) TkR86C NKD Takr86C CG6515 Drosophila melanogaster (Fruit fly) 504 G-protein coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217] GO:0002121; GO:0004995; GO:0005887; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016021 0 0 0 PF00001; P33005 CHOYP_LOC100535716.1.3 m.23295 sp KALM_CHICK 50.943 53 24 1 233 283 115 167 1.16E-09 63.9 KALM_CHICK reviewed Anosmin-1 (Kallmann syndrome protein homolog) ANOS1 KAL KAL1 Gallus gallus (Chicken) 675 cell adhesion [GO:0007155] GO:0004867; GO:0005576; GO:0007155; GO:0009986 0 0 0 PF00041;PF00095; P38532 CHOYP_HSF1.1.2 m.9793 sp HSF1_MOUSE 38.645 502 244 15 2 457 11 494 1.16E-90 289 HSF1_MOUSE reviewed Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1) Hsf1 Mus musculus (Mouse) 525 cellular response to heat [GO:0034605]; defense response [GO:0006952]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; female meiotic division [GO:0007143]; in utero embryonic development [GO:0001701]; mRNA transcription [GO:0009299]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein phosphorylation [GO:0006468]; response to heat [GO:0009408]; response to lipopolysaccharide [GO:0032496]; spermatogenesis [GO:0007283] GO:0000122; GO:0000978; GO:0000979; GO:0001078; GO:0001162; GO:0001701; GO:0001892; GO:0003677; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0006952; GO:0007143; GO:0007283; GO:0008285; GO:0009299; GO:0009408; GO:0032496; GO:0032720; GO:0034605; GO:0040018; GO:0043234; GO:0043565; GO:0045120; GO:0045944; GO:0060136 0 0 0 PF00447;PF06546; P46782 CHOYP_RS5.1.2 m.146 sp RS5_HUMAN 89.756 205 19 2 23 226 1 204 1.16E-134 379 RS5_HUMAN reviewed "40S ribosomal protein S5 [Cleaved into: 40S ribosomal protein S5, N-terminally processed]" RPS5 Homo sapiens (Human) 204 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational fidelity [GO:0006450]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000028; GO:0000184; GO:0003723; GO:0003729; GO:0003735; GO:0005654; GO:0005829; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006450; GO:0006614; GO:0016020; GO:0019083; GO:0019843; GO:0022627; GO:0030529; GO:0031012; GO:0044822; GO:0070062 0 0 cd14867; PF00177; P49445 CHOYP_NEMVEDRAFT_V1G136229.2.2 m.64491 sp PTN7_RAT 43.511 262 139 7 347 605 92 347 1.16E-57 201 PTN7_RAT reviewed Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Hematopoietic protein-tyrosine phosphatase) (HEPTP) (Protein-tyrosine phosphatase LC-PTP) Ptpn7 Lcptp Rattus norvegicus (Rat) 359 0 GO:0004725; GO:0005829; GO:0005856; GO:0009898 0 0 0 PF00102; P56376 CHOYP_ACYP1.1.1 m.17224 sp ACYP1_MOUSE 58.511 94 39 0 31 124 4 97 1.16E-33 115 ACYP1_MOUSE reviewed "Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1)" Acyp1 Acype Mus musculus (Mouse) 99 0 GO:0003998; GO:0070062 0 0 0 PF00708; P74148 CHOYP_RL40.1.7 m.3623 sp Y1388_SYNY3 27.152 151 100 2 8 149 5 154 1.16E-10 60.5 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P79345 CHOYP_NPC2.7.7 m.40150 sp NPC2_BOVIN 41.558 77 43 2 17 92 24 99 1.16E-13 65.9 NPC2_BOVIN reviewed Epididymal secretory protein E1 (EPV20) (Niemann Pick type C2 protein homolog) NPC2 Bos taurus (Bovine) 149 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; response to virus [GO:0009615] GO:0005764; GO:0005783; GO:0008203; GO:0009615; GO:0015485; GO:0030301; GO:0032367; GO:0033344; GO:0042632; GO:0070062 0 0 0 PF02221; P83425 CHOYP_CBLN14.2.2 m.56958 sp HIP_MYTED 29.231 130 87 2 47 173 85 212 1.16E-10 61.2 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q01484 CHOYP_LOC100639010.7.9 m.47274 sp ANK2_HUMAN 30.896 670 360 6 3 569 51 720 1.16E-96 327 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q02446 CHOYP_SP3.1.1 m.9839 sp SP4_HUMAN 67.059 170 36 5 637 791 615 779 1.16E-72 256 SP4_HUMAN reviewed Transcription factor Sp4 (SPR-1) SP4 Homo sapiens (Human) 784 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006357; GO:0015630; GO:0045171; GO:0046872 0 0 0 0 Q05909 CHOYP_LOC578045.1.5 m.24871 sp PTPRG_MOUSE 28.879 696 435 20 389 1038 756 1437 1.16E-75 276 PTPRG_MOUSE reviewed Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) Ptprg Mus musculus (Mouse) 1442 negative regulation of epithelial cell migration [GO:0010633]; toxin transport [GO:1901998] GO:0004725; GO:0010633; GO:0016021; GO:0042802; GO:0070062; GO:1901998 0 0 0 PF00194;PF00041;PF00102; Q08DE2 CHOYP_LOC655280.1.1 m.12771 sp T185B_BOVIN 51.136 352 158 3 1 340 1 350 1.16E-125 367 T185B_BOVIN reviewed Transmembrane protein 185B (Protein FAM11B) TMEM185B FAM11B Bos taurus (Bovine) 350 0 GO:0016021 0 0 0 PF10269; Q08DY9 CHOYP_LOC100663575.1.1 m.34359 sp CASP3_BOVIN 35.714 252 137 5 291 538 45 275 1.16E-41 154 CASP3_BOVIN reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) 275 erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182] GO:0005737; GO:0030182; GO:0030216; GO:0030218; GO:0097194; GO:0097200 0 0 0 0 Q09139 CHOYP_FABP7.1.2 m.22674 sp FABP7_BOVIN 35.897 117 70 3 9 124 4 116 1.16E-14 68.9 FABP7_BOVIN reviewed "Fatty acid-binding protein, brain (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7)" FABP7 Bos taurus (Bovine) 132 cell proliferation in forebrain [GO:0021846]; neurogenesis [GO:0022008]; prepulse inhibition [GO:0060134] GO:0005215; GO:0005654; GO:0005737; GO:0005911; GO:0008289; GO:0021846; GO:0022008; GO:0042995; GO:0043025; GO:0060134; GO:0071944 0 0 0 PF00061; Q0EEE2 CHOYP_LOC100372915.7.7 m.66321 sp PTHD3_MOUSE 27.346 863 578 15 3 836 61 903 1.16E-108 360 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q15904 CHOYP_ATP6AP1.1.1 m.18150 sp VAS1_HUMAN 29.577 426 267 14 26 422 44 465 1.16E-38 149 VAS1_HUMAN reviewed V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1) ATP6AP1 ATP6IP1 ATP6S1 VATPS1 XAP3 Homo sapiens (Human) 470 ATP hydrolysis coupled proton transport [GO:0015991]; establishment of organelle localization [GO:0051656]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; pH reduction [GO:0045851]; positive regulation of bone resorption [GO:0045780]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoclast development [GO:2001206]; proton transport [GO:0015992]; transferrin transport [GO:0033572] GO:0005215; GO:0005524; GO:0008286; GO:0010008; GO:0015991; GO:0015992; GO:0016021; GO:0016469; GO:0017137; GO:0033180; GO:0033572; GO:0034220; GO:0045669; GO:0045780; GO:0045851; GO:0045921; GO:0046933; GO:0046961; GO:0051656; GO:0070062; GO:0070374; GO:2001206 0 0 0 PF05827; Q2NKT1 CHOYP_LOC100372995.3.3 m.48855 sp PROF4_BOVIN 46.957 115 60 1 40 153 14 128 1.16E-32 115 PROF4_BOVIN reviewed Profilin-4 PFN4 Bos taurus (Bovine) 129 sequestering of actin monomers [GO:0042989] GO:0003785; GO:0005938; GO:0008289; GO:0015629; GO:0042989 0 0 0 PF00235; Q2TA25 CHOYP_PLK1.2.2 m.39815 sp PLK1_BOVIN 76.966 178 41 0 1 178 69 246 1.16E-103 313 PLK1_BOVIN reviewed Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) PLK1 Bos taurus (Bovine) 602 centrosome organization [GO:0051297]; establishment of protein localization [GO:0045184]; female meiosis chromosome segregation [GO:0016321]; G2/M transition of mitotic cell cycle [GO:0000086]; G2 DNA damage checkpoint [GO:0031572]; homologous chromosome segregation [GO:0045143]; microtubule bundle formation [GO:0001578]; mitotic cytokinesis [GO:0000281]; mitotic nuclear division [GO:0007067]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein destabilization [GO:0031648]; protein localization to chromatin [GO:0071168]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein binding [GO:0043393]; synaptonemal complex disassembly [GO:0070194] GO:0000070; GO:0000086; GO:0000122; GO:0000281; GO:0000776; GO:0000785; GO:0000795; GO:0000922; GO:0000942; GO:0001578; GO:0004674; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0005813; GO:0005819; GO:0005876; GO:0006468; GO:0007067; GO:0007094; GO:0008017; GO:0010800; GO:0016321; GO:0016567; GO:0018105; GO:0030496; GO:0031572; GO:0031648; GO:0032436; GO:0043066; GO:0043393; GO:0045143; GO:0045184; GO:0045736; GO:0051233; GO:0051297; GO:0051443; GO:0070194; GO:0071168; GO:1901673; GO:1904668 0 0 cd13118;cd13117; PF00069;PF00659; Q39967 CHOYP_RCOM_0669350.1.1 m.25216 sp ALL5_HEVBR 100 151 0 0 27 177 1 151 1.16E-83 246 ALL5_HEVBR reviewed Major latex allergen Hev b 5 (allergen Hev b 5) 0 Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis) 151 0 0 0 0 0 0 Q3V2K1 CHOYP_LOC100372825.1.1 m.48176 sp CX065_MOUSE 31.034 116 66 3 18 119 2 117 1.16E-11 63.9 CX065_MOUSE reviewed Uncharacterized protein CXorf65 homolog Gm614 Mus musculus (Mouse) 191 0 0 0 0 0 0 Q40588 CHOYP_LOC100198324.6.6 m.65579 sp ASO_TOBAC 27.936 562 320 18 103 630 55 565 1.16E-49 186 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q460N3 CHOYP_ROCO6.1.1 m.59690 sp PAR15_HUMAN 28.839 267 147 10 24 268 213 458 1.16E-19 92 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_NEMVEDRAFT_V1G202195.2.4 m.37282 sp SVEP1_HUMAN 30.247 162 109 4 415 575 1002 1160 1.16E-12 75.5 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q502K3 CHOYP_TVAG_067900.3.7 m.21052 sp ANR52_DANRE 31.894 301 186 3 44 343 44 326 1.16E-43 164 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q5BK63 CHOYP_AAEL_AAEL009414.1.1 m.639 sp NDUA9_RAT 39.687 383 199 6 179 553 12 370 1.16E-82 266 NDUA9_RAT reviewed "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Sperm flagella protein 3)" Ndufa9 Rattus norvegicus (Rat) 377 response to glucose [GO:0009749]; ubiquinone-6 biosynthetic process [GO:1901006] GO:0003954; GO:0005739; GO:0005747; GO:0005759; GO:0009749; GO:1901006 0 0 0 PF05368; Q5I0S8 CHOYP_MPET_1013.2.2 m.58808 sp ILEU_XENTR 38.816 304 178 4 1 297 4 306 1.16E-67 218 ILEU_XENTR reviewed Leukocyte elastase inhibitor (Serpin B1) serpinb1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 377 0 GO:0004867; GO:0005615; GO:0005737 0 0 0 PF00079; Q5M7K0 CHOYP_TIM22.1.1 m.48703 sp TIM22_XENTR 50 182 84 3 48 223 6 186 1.16E-51 168 TIM22_XENTR reviewed Mitochondrial import inner membrane translocase subunit Tim22 timm22 tim22 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 186 protein import into mitochondrial inner membrane [GO:0045039] GO:0015266; GO:0016021; GO:0030943; GO:0042721; GO:0045039 0 0 0 PF02466; Q5R9A7 CHOYP_NEMVEDRAFT_V1G241468.1.1 m.37892 sp GP155_PONAB 37.143 140 71 1 1 140 714 836 1.16E-22 96.3 GP155_PONAB reviewed Integral membrane protein GPR155 GPR155 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 872 intracellular signal transduction [GO:0035556]; transmembrane transport [GO:0055085] GO:0005622; GO:0016021; GO:0035556; GO:0055085 0 0 0 PF00610;PF03547; Q5RA75 CHOYP_PHUM_PHUM293090.2.2 m.53498 sp F135A_PONAB 66.879 314 100 4 834 1146 785 1095 1.16E-134 440 F135A_PONAB reviewed Protein FAM135A FAM135A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1095 0 0 0 0 0 PF12394;PF05057; Q5RD64 CHOYP_LOC100377926.1.1 m.27671 sp CNTP2_PONAB 30.769 195 128 4 7 195 598 791 1.16E-18 93.6 CNTP2_PONAB reviewed Contactin-associated protein-like 2 CNTNAP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1331 cell adhesion [GO:0007155]; protein localization to juxtaparanode region of axon [GO:0071205] GO:0007155; GO:0016021; GO:0044224; GO:0071205 0 0 0 PF00754;PF02210; Q60HC3 CHOYP_NEMVEDRAFT_V1G115454.1.2 m.40806 sp HNRPF_MACFA 56.637 113 48 1 64 175 25 137 1.16E-34 129 HNRPF_MACFA reviewed "Heterogeneous nuclear ribonucleoprotein F (hnRNP F) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]" HNRNPF HNRPF QflA-17741 QtsA-10715 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 415 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003727; GO:0005654; GO:0005681; GO:0006397; GO:0008380; GO:0043484 0 0 0 PF00076;PF08080; Q67XX3 CHOYP_LOC100374815.1.1 m.44465 sp FB252_ARATH 24.405 168 102 4 145 305 198 347 1.16E-07 57 FB252_ARATH reviewed F-box protein At5g06550 At5g06550 F15M7.8 Arabidopsis thaliana (Mouse-ear cress) 502 histone H4-R3 methylation [GO:0043985]; positive regulation of seed germination [GO:0010030] GO:0000987; GO:0005634; GO:0010030; GO:0043985 0 0 0 0 Q69Z37 CHOYP_LOC100367581.2.3 m.38409 sp SAM9L_MOUSE 26.234 1155 717 47 306 1396 169 1252 1.16E-71 270 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6B9X6 CHOYP_LOC100372473.1.5 m.7845 sp VWKA_DICDI 27.82 133 89 4 1 128 133 263 1.16E-07 56.6 VWKA_DICDI reviewed Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) 625 contractile vacuole discharge [GO:0070177]; contractile vacuole organization [GO:0033298]; hypotonic response [GO:0006971]; mitotic cytokinesis [GO:0000281]; myosin II filament organization [GO:0031038]; peptidyl-serine modification [GO:0018209]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; regulation of sorocarp development [GO:0031156]; sorocarp morphogenesis [GO:0031288] GO:0000281; GO:0000331; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006971; GO:0018107; GO:0018209; GO:0031038; GO:0031156; GO:0031164; GO:0031288; GO:0033298; GO:0048471; GO:0070177 0 0 0 PF02816; Q6DET9 CHOYP_EF1B.5.7 m.44882 sp EF1B_XENTR 69.512 82 25 0 25 106 1 82 1.16E-31 115 EF1B_XENTR reviewed Elongation factor 1-beta (EF-1-beta) eef1b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 228 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; Q6DGV7 CHOYP_BRAFLDRAFT_206123.1.2 m.7836 sp M17L2_DANRE 43.293 164 89 3 20 183 29 188 1.16E-41 142 M17L2_DANRE reviewed Mpv17-like protein 2 mpv17l2 zgc:92754 Danio rerio (Zebrafish) (Brachydanio rerio) 199 0 GO:0005743; GO:0016021 0 0 0 PF04117; Q6GLN5 CHOYP_NDFIP2.1.1 m.64716 sp NFIP1_XENLA 39.171 217 108 6 4 206 6 212 1.16E-35 127 NFIP1_XENLA reviewed NEDD4 family-interacting protein 1 ndfip1 Xenopus laevis (African clawed frog) 212 metal ion transport [GO:0030001]; vacuolar transport [GO:0007034] GO:0000139; GO:0007034; GO:0016021; GO:0030001 0 0 0 PF10176; Q6NUB3 CHOYP_OCTL.1.1 m.27218 sp S22AF_XENLA 38.278 209 126 2 25 231 279 486 1.16E-42 154 S22AF_XENLA reviewed Solute carrier family 22 member 15 slc22a15 Xenopus laevis (African clawed frog) 531 ion transport [GO:0006811] GO:0006811; GO:0016021; GO:0022857 0 0 cd06174; PF00083; Q6P9T8 CHOYP_LOC100366486.1.1 m.15010 sp TBB4B_RAT 98.758 161 2 0 100 260 14 174 1.16E-113 337 TBB4B_RAT reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Rattus norvegicus (Rat) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q6QAP7 CHOYP_LOC100199472.1.1 m.21985 sp RS17_PIG 86.066 122 17 0 3 124 1 122 1.16E-75 223 RS17_PIG reviewed 40S ribosomal protein S17 RPS17 Sus scrofa (Pig) 135 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00833; Q6R7B4 CHOYP_Y003.1.1 m.31014 sp Y003_OSHVF 98.639 147 2 0 1 147 108 254 1.16E-106 307 Y003_OSHVF reviewed Uncharacterized protein ORF3 ORF3 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 254 0 0 0 0 0 0 Q6R7G0 CHOYP_YG31B.2.3 m.9010 sp Y068_OSHVF 21.586 681 441 19 12 603 16 692 1.16E-35 147 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6ZRF8 CHOYP_LOC100374741.32.83 m.32663 sp RN207_HUMAN 24.444 225 139 10 17 234 103 303 1.16E-09 63.9 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q74FW6 CHOYP_LOC100375322.1.1 m.22016 sp TSAL_GEOSL 41.995 381 219 2 94 473 13 392 1.16E-74 243 TSAL_GEOSL reviewed L-threonine ammonia-lyase (EC 4.3.1.19) (L-serine ammonia-lyase) (EC 4.3.1.17) (Threonine/serine ammonia-lyase) tdcB GSU0486 Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) 402 cellular amino acid biosynthetic process [GO:0008652]; isoleucine biosynthetic process [GO:0009097]; L-serine catabolic process [GO:0006565]; threonine catabolic process [GO:0006567] GO:0003941; GO:0004794; GO:0005737; GO:0006565; GO:0006567; GO:0008652; GO:0009097; GO:0016597; GO:0030170 PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1. {ECO:0000269|PubMed:18245290}. 0 0 PF13291;PF00291; Q7TP17 CHOYP_BRAFLDRAFT_202693.4.4 m.31263 sp U2AF4_RAT 81.683 202 31 1 12 213 1 196 1.16E-122 351 U2AF4_RAT reviewed Splicing factor U2AF 26 kDa subunit (Liver regeneration-related protein LRRG157/LRRG158) (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) U2af1l4 Cb2-806 Cb2-807 Rattus norvegicus (Rat) 220 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005681; GO:0005737; GO:0016607; GO:0046872; GO:0089701 0 0 0 PF00076;PF00642; Q7ZV00 CHOYP_OTU6B.2.2 m.59136 sp OTU6B_DANRE 23.626 182 90 5 305 475 145 288 1.16E-06 54.7 OTU6B_DANRE reviewed OTU domain-containing protein 6B (EC 3.4.19.12) otud6b zgc:56305 Danio rerio (Zebrafish) (Brachydanio rerio) 293 0 GO:0036459 0 0 0 PF02338; Q80X50 CHOYP_BRAFLDRAFT_125234.1.2 m.18717 sp UBP2L_MOUSE 43.21 81 42 2 36 116 27 103 1.16E-13 78.2 UBP2L_MOUSE reviewed Ubiquitin-associated protein 2-like Ubap2l Mus musculus (Mouse) 1107 binding of sperm to zona pellucida [GO:0007339]; hematopoietic stem cell homeostasis [GO:0061484] GO:0005671; GO:0007339; GO:0031519; GO:0044822; GO:0061484 0 0 0 PF12478; Q80XI3 CHOYP_EIF4G3.1.1 m.64770 sp IF4G3_MOUSE 46.914 243 126 3 16 255 1337 1579 1.16E-65 224 IF4G3_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Eif4g3 Mus musculus (Mouse) 1579 positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283] GO:0001934; GO:0003743; GO:0007283; GO:0044822; GO:0045727; GO:0060903 0 0 0 PF02847;PF02854;PF02020; Q86V88 CHOYP_PHUM_PHUM564750.1.1 m.2209 sp MGDP1_HUMAN 42.138 159 88 2 11 169 5 159 1.16E-38 136 MGDP1_HUMAN reviewed Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) MDP1 Homo sapiens (Human) 176 0 GO:0004725; GO:0046872; GO:0070062 0 0 0 PF12689; Q8BIQ3 CHOYP_ZNF85.1.1 m.65738 sp ZNF2_MOUSE 36.331 278 159 3 604 879 159 420 1.16E-46 176 ZNF2_MOUSE reviewed Zinc finger protein 2 (Zinc finger protein 661) (Zfp-661) Znf2 Zfp661 Mus musculus (Mouse) 427 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q8BL66 CHOYP_EEA1.1.1 m.9573 sp EEA1_MOUSE 41.369 336 197 0 874 1209 1074 1409 1.16E-58 225 EEA1_MOUSE reviewed Early endosome antigen 1 Eea1 Mus musculus (Mouse) 1411 endocytosis [GO:0006897]; vesicle fusion [GO:0006906] GO:0005545; GO:0005768; GO:0005769; GO:0005829; GO:0005969; GO:0006897; GO:0006906; GO:0019897; GO:0030742; GO:0031410; GO:0031901; GO:0042803; GO:0044308; GO:0046872; GO:0055037; GO:0070062 0 0 0 PF01363; Q8BQQ1 CHOYP_ZDHHC14.1.2 m.26219 sp ZDH14_MOUSE 68.317 101 32 0 31 131 236 336 1.16E-43 157 ZDH14_MOUSE reviewed Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) Zdhhc14 Mus musculus (Mouse) 489 protein palmitoylation [GO:0018345] GO:0005783; GO:0008270; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q8BWJ3 CHOYP_LOC100368228.1.3 m.6023 sp KPB2_MOUSE 33.216 283 156 10 4 267 530 798 1.16E-28 118 KPB2_MOUSE reviewed "Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)" Phka2 Mus musculus (Mouse) 1235 glycogen metabolic process [GO:0005977] GO:0004689; GO:0005886; GO:0005964; GO:0005977 PATHWAY: Glycan biosynthesis; glycogen metabolism. 0 0 PF00723; Q8BXA0 CHOYP_BRAFLDRAFT_76431.2.2 m.61958 sp LRFN5_MOUSE 33.645 107 66 5 22 125 285 389 1.16E-08 55.1 LRFN5_MOUSE reviewed Leucine-rich repeat and fibronectin type-III domain-containing protein 5 Lrfn5 Kiaa4208 Salm5 Mus musculus (Mouse) 719 0 GO:0009986; GO:0016021 0 0 0 PF07679;PF13306; Q8C8H8 CHOYP_LOC100552773.1.2 m.7103 sp KY_MOUSE 26.99 515 333 19 141 642 151 635 1.16E-47 181 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8IT98 CHOYP_RS18.11.11 m.64024 sp RS18_ARGIR 88.971 136 15 0 1 136 13 148 1.16E-90 263 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8IUK8 CHOYP_C1QL2.2.32 m.2213 sp CBLN2_HUMAN 46.429 56 27 2 219 271 94 149 1.16E-06 52.4 CBLN2_HUMAN reviewed Cerebellin-2 CBLN2 UNQ1892/PRO4338 Homo sapiens (Human) 224 positive regulation of synapse assembly [GO:0051965] GO:0005615; GO:0051965 0 0 0 PF00386; Q8R0M8 CHOYP_DPER_GL21167.1.2 m.49247 sp MOT5_MOUSE 23.576 509 342 7 30 535 30 494 1.16E-37 148 MOT5_MOUSE reviewed Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) 500 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; Q8R4Y8 CHOYP_RTTN.3.3 m.54097 sp RTTN_MOUSE 30.134 823 481 17 13 781 1355 2137 1.16E-89 313 RTTN_MOUSE reviewed Rotatin Rttn Mus musculus (Mouse) 2226 cilium organization [GO:0044782]; determination of left/right symmetry [GO:0007368] GO:0005737; GO:0005813; GO:0007368; GO:0016021; GO:0036064; GO:0044782 0 0 0 PF14726; Q8VIG3 CHOYP_LOC100375551.1.2 m.27488 sp RSPH1_MOUSE 57.252 262 112 0 17 278 17 278 1.16E-94 285 RSPH1_MOUSE reviewed Radial spoke head 1 homolog (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) Rsph1 Tsga2 Mus musculus (Mouse) 301 axoneme assembly [GO:0035082]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] GO:0000794; GO:0001520; GO:0005634; GO:0005737; GO:0005829; GO:0007286; GO:0031514; GO:0035082; GO:0036126; GO:0051321; GO:0072687 0 0 0 PF02493; Q8WVZ9 CHOYP_BACH1.11.17 m.18634 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 1.16E-08 61.6 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q8WZ42 CHOYP_TITIN.12.19 m.51321 sp TITIN_HUMAN 31.034 435 299 1 11 445 13035 13468 1.16E-55 203 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q90YQ6 CHOYP_RS17.1.11 m.3609 sp RS17_ICTPU 82.09 134 22 2 1 134 1 132 1.16E-74 221 RS17_ICTPU reviewed 40S ribosomal protein S17 rps17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 134 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00833; Q90YQ6 CHOYP_RS17.2.11 m.7321 sp RS17_ICTPU 82.09 134 22 2 1 134 1 132 1.16E-74 221 RS17_ICTPU reviewed 40S ribosomal protein S17 rps17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 134 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00833; Q95230 CHOYP_LOC100373522.3.5 m.29307 sp SP17_PAPHA 43.396 159 73 4 26 174 1 152 1.16E-30 119 SP17_PAPHA reviewed Sperm surface protein Sp17 (Sperm autoantigenic protein 17) SPA17 SP17 Papio hamadryas (Hamadryas baboon) 163 binding of sperm to zona pellucida [GO:0007339] GO:0007339; GO:0016020 0 0 0 PF00612;PF02197; Q95LU3 CHOYP_FBCD1.1.3 m.46935 sp FBCD1_MACFA 33.233 331 198 8 14 323 98 426 1.16E-51 179 FBCD1_MACFA reviewed Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 431 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q96MM6 CHOYP_HS12B.6.14 m.35163 sp HS12B_HUMAN 33.906 640 358 14 6 585 50 684 1.16E-109 346 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99315 CHOYP_LOC100121360.1.1 m.56328 sp YG31B_YEAST 24.638 276 187 7 118 392 596 851 1.16E-14 82.8 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q99M80 CHOYP_MEG10.71.91 m.55478 sp PTPRT_MOUSE 33.951 324 193 6 376 692 760 1069 1.16E-46 182 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BXX0 CHOYP_TVAG_268110.8.13 m.47203 sp EMIL2_HUMAN 32.558 129 61 4 293 403 907 1027 1.16E-07 57.8 EMIL2_HUMAN reviewed EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) 1053 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030023; GO:0031012 0 0 0 PF00386;PF07546; Q9CR48 CHOYP_LOC100182050.1.1 m.57193 sp DRAM2_MOUSE 32.171 258 169 5 3 257 5 259 1.16E-35 131 DRAM2_MOUSE reviewed DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) Dram2 Tmem77 Mus musculus (Mouse) 267 apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601] GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006914; GO:0006915; GO:0007601; GO:0010506; GO:0016021; GO:0016324; GO:0043231; GO:0045494 0 0 0 PF10277; Q9D114 CHOYP_MESH1.1.3 m.13824 sp MESH1_MOUSE 69.375 160 49 0 37 196 18 177 1.16E-81 243 MESH1_MOUSE reviewed "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)" Hddc3 Mesh1 Mus musculus (Mouse) 179 guanosine tetraphosphate metabolic process [GO:0015969]; response to starvation [GO:0042594] GO:0008728; GO:0008893; GO:0015969; GO:0042594; GO:0046872 0 0 0 PF13328; Q9D1D1 CHOYP_PHUM_PHUM503620.1.1 m.7659 sp TSN11_MOUSE 37.395 238 145 2 21 254 16 253 1.16E-58 189 TSN11_MOUSE reviewed Tetraspanin-11 (Tspan-11) Tspan11 Mus musculus (Mouse) 253 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q9NFP5 CHOYP_SH3L1.5.5 m.50096 sp SH3BG_DROME 43.59 117 56 3 1 108 1 116 1.16E-24 100 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9NRP2 CHOYP_COXM2.1.2 m.27876 sp COXM2_HUMAN 47.541 61 32 0 34 94 1 61 1.16E-16 72 COXM2_HUMAN reviewed COX assembly mitochondrial protein 2 homolog CMC2 C16orf61 DC13 Homo sapiens (Human) 79 0 GO:0005739 0 0 0 PF08583; Q9NUV9 CHOYP_GIMAP7.1.1 m.61370 sp GIMA4_HUMAN 41.951 205 117 1 509 713 29 231 1.16E-49 180 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9NUV9 CHOYP_LOC100007616.1.1 m.33390 sp GIMA4_HUMAN 33.648 318 193 5 22 328 16 326 1.16E-53 181 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9NUV9 CHOYP_LOC100692036.1.2 m.63650 sp GIMA4_HUMAN 36.842 209 128 2 62 270 32 236 1.16E-40 148 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9U3W6 CHOYP_LOC100370446.6.12 m.32606 sp MAB21_DROME 24.855 173 111 6 52 214 180 343 1.16E-06 53.9 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; Q9UGM1 CHOYP_CHRNA9.1.3 m.33689 sp ACHA9_HUMAN 25.949 474 328 9 28 495 18 474 1.16E-57 201 ACHA9_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) CHRNA9 NACHRA9 Homo sapiens (Human) 479 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005886; GO:0005887; GO:0005892; GO:0007204; GO:0007271; GO:0015276; GO:0022848; GO:0030054; GO:0042166; GO:0042472; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; Q9UKB3 CHOYP_LOC100369649.1.1 m.48975 sp DJC12_HUMAN 34.673 199 101 4 1 171 1 198 1.16E-39 136 DJC12_HUMAN reviewed DnaJ homolog subfamily C member 12 (J domain-containing protein 1) DNAJC12 JDP1 Homo sapiens (Human) 198 0 0 0 0 cd06257; PF00226; Q9ULJ7 CHOYP_AFUA_1G01020.37.50 m.45202 sp ANR50_HUMAN 36.745 381 236 1 1 376 527 907 1.16E-60 214 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VR50 CHOYP_AGAP_AGAP000544.2.2 m.48687 sp S35E1_DROME 49.138 348 174 2 10 357 15 359 1.16E-103 314 S35E1_DROME reviewed Solute carrier family 35 member E1 homolog CG14621 Drosophila melanogaster (Fruit fly) 373 carbohydrate transmembrane transport [GO:0034219] GO:0016021; GO:0034219 0 0 0 PF03151; Q9W141 CHOYP_ISCW_ISCW016254.2.5 m.38599 sp ATPK_DROME 30.476 105 73 0 33 137 3 107 1.16E-12 63.2 ATPK_DROME reviewed "Putative ATP synthase subunit f, mitochondrial" CG4692 Drosophila melanogaster (Fruit fly) 107 ATP biosynthetic process [GO:0006754]; lateral inhibition [GO:0046331]; proton transport [GO:0015992] GO:0005739; GO:0005811; GO:0006754; GO:0015992; GO:0031966; GO:0045263; GO:0046331 0 0 0 PF10206; Q9XVM9 CHOYP_TSP-15.1.1 m.27289 sp TSN15_CAEEL 37.931 116 49 7 1 116 128 220 1.16E-11 63.5 TSN15_CAEEL reviewed Tetraspanin-15 tsp-15 F53B6.1 Caenorhabditis elegans 258 cell surface receptor signaling pathway [GO:0007166]; cuticle development involved in collagen and cuticulin-based cuticle molting cycle [GO:0042338] GO:0005887; GO:0007166; GO:0042338 0 0 0 PF00335; Q9Y2Q3 CHOYP_BRAFLDRAFT_281070.1.1 m.1319 sp GSTK1_HUMAN 48.165 218 110 2 3 218 2 218 1.16E-74 228 GSTK1_HUMAN reviewed Glutathione S-transferase kappa 1 (EC 2.5.1.18) (GST 13-13) (GST class-kappa) (GSTK1-1) (hGSTK1) (Glutathione S-transferase subunit 13) GSTK1 HDCMD47P Homo sapiens (Human) 226 epithelial cell differentiation [GO:0030855]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749] GO:0004364; GO:0004602; GO:0005102; GO:0005622; GO:0005743; GO:0005759; GO:0005777; GO:0006749; GO:0015035; GO:0016020; GO:0030855; GO:0043231; GO:0070062; GO:1901687 0 0 0 PF01323; Q9Y6R7 CHOYP_LOC580187.1.4 m.35483 sp FCGBP_HUMAN 23.188 414 291 12 143 543 21 420 1.16E-17 90.9 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A0JM12 CHOYP_MEG11.8.25 m.39826 sp MEG10_XENTR 39.286 196 108 8 191 384 399 585 1.17E-24 109 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AG06 CHOYP_PHUM_PHUM002690.1.1 m.21363 sp MEIOC_MOUSE 49.78 227 97 3 546 755 692 918 1.17E-57 216 MEIOC_MOUSE reviewed Meiosis-specific coiled-coil domain-containing protein MEIOC (Meiosis-specific with coiled-coil domain protein) Meioc Gm1564 Mus musculus (Mouse) 965 double-strand break repair [GO:0006302]; female meiosis I [GO:0007144]; male meiosis I [GO:0007141]; metaphase plate congression [GO:0051310]; mRNA stabilization [GO:0048255]; oocyte development [GO:0048599]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] GO:0005737; GO:0006302; GO:0007130; GO:0007141; GO:0007144; GO:0007283; GO:0048255; GO:0048599; GO:0051310 0 0 0 PF15189; A2AX52 CHOYP_LOC100538183.2.2 m.42703 sp CO6A4_MOUSE 23.102 1212 757 37 1 1168 84 1164 1.17E-56 220 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A3RLT6 CHOYP_RSSA.2.10 m.4240 sp RSSA_PINFU 71.667 120 29 5 1 118 174 290 1.17E-42 145 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A4IF63 CHOYP_BRAFLDRAFT_87340.1.6 m.20674 sp TRIM2_BOVIN 24.658 146 103 4 26 168 602 743 1.17E-06 51.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF87 CHOYP_LOC590838.1.1 m.24953 sp GNPAT_BOVIN 40.635 630 355 6 56 680 30 645 1.17E-168 503 GNPAT_BOVIN reviewed Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) GNPAT Bos taurus (Bovine) 680 ether lipid biosynthetic process [GO:0008611]; glycerophospholipid metabolic process [GO:0006650] GO:0005778; GO:0006650; GO:0008611; GO:0016287 PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism. 0 0 PF01553; B7PY76 CHOYP_WDR12.1.1 m.13380 sp WDR12_IXOSC 54.739 422 183 5 12 426 5 425 1.17E-166 478 WDR12_IXOSC reviewed Ribosome biogenesis protein WDR12 homolog ISCW009002 Ixodes scapularis (Black-legged tick) (Deer tick) 425 "maturation of 5.8S rRNA [GO:0000460]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA [GO:0000470]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" GO:0000460; GO:0000463; GO:0000466; GO:0000470; GO:0005654; GO:0030687; GO:0043021; GO:0070545 0 0 0 PF08154;PF00400; B7QDG3 CHOYP_NNRE.2.2 m.27199 sp NNRE_IXOSC 54.924 264 110 6 8 265 10 270 1.17E-97 290 NNRE_IXOSC reviewed NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase) ISCW022186 Ixodes scapularis (Black-legged tick) (Deer tick) 275 0 GO:0000166; GO:0005739; GO:0046872; GO:0052856; GO:0052857 0 0 0 PF03853; D3YXG0 CHOYP_HMCN1.12.44 m.30914 sp HMCN1_MOUSE 26.234 1357 840 57 28 1340 488 1727 1.17E-77 290 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O00370 CHOYP_LOC100536368.2.2 m.61348 sp LORF2_HUMAN 24.828 874 553 21 5 800 8 855 1.17E-56 216 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O16277 CHOYP_LOC100885792.2.3 m.42696 sp H16_CAEEL 42.975 121 55 4 1 118 1 110 1.17E-19 85.1 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O46160 CHOYP_RL14.6.9 m.44621 sp RL14_LUMRU 64.234 137 48 1 12 147 8 144 1.17E-57 179 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O70277 CHOYP_BRAFLDRAFT_69765.15.23 m.52739 sp TRIM3_RAT 27.619 105 73 2 122 223 622 726 1.17E-08 58.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_87307.5.5 m.64724 sp TRIM3_HUMAN 26.19 126 87 3 141 264 622 743 1.17E-06 53.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88572 CHOYP_LOC578656.4.15 m.20716 sp LRP6_MOUSE 26.457 858 580 26 44 878 100 929 1.17E-81 296 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; O93310 CHOYP_LOC100376067.1.3 m.17524 sp RAD21_XENLA 40.909 88 52 0 399 486 312 399 1.17E-11 70.9 RAD21_XENLA reviewed Double-strand-break repair protein rad21 homolog (SCC1 homolog) rad21 Xenopus laevis (African clawed frog) 629 apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168] GO:0000228; GO:0000775; GO:0006281; GO:0006915; GO:0007059; GO:0007067; GO:0051301; GO:0071168 0 0 0 PF04824;PF04825; O96064 CHOYP_LOC100373653.2.3 m.43048 sp MYSP_MYTGA 89.13 92 10 0 1 92 663 754 1.17E-44 156 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; O96102 CHOYP_CALM.19.50 m.30908 sp CALM_PHYPO 55.385 130 55 1 51 177 19 148 1.17E-47 155 CALM_PHYPO reviewed Calmodulin (CaM) 0 Physarum polycephalum (Slime mold) 149 0 GO:0005509 0 0 0 PF13499; P04352 CHOYP_CALM.2.50 m.1297 sp CALM_CHLRE 56.954 151 64 1 23 173 2 151 1.17E-58 183 CALM_CHLRE reviewed Calmodulin (CaM) 0 Chlamydomonas reinhardtii (Chlamydomonas smithii) 163 0 GO:0005509 0 0 0 PF13499; P07192 CHOYP_BRAFLDRAFT_220425.1.4 m.3379 sp MAL3_DROME 39.261 568 305 13 49 592 23 574 1.17E-133 405 MAL3_DROME reviewed Maltase A3 (EC 3.2.1.20) (Larval visceral protein L) Mal-A3 LvpL CG8695 Drosophila melanogaster (Fruit fly) 574 0 GO:0004558; GO:0032450 0 0 0 PF00128; P12545 CHOYP_LOC100702671.2.2 m.44555 sp PLMN_MACMU 40.594 202 94 6 27 218 102 287 1.17E-36 141 PLMN_MACMU reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macaca mulatta (Rhesus macaque) 810 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P15252 CHOYP_REF.1.2 m.24260 sp REF_HEVBR 100 138 0 0 1 138 1 138 1.17E-96 277 REF_HEVBR reviewed Rubber elongation factor protein (HbREF) (allergen Hev b 1) 0 Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis) 138 0 GO:0005737 0 0 0 PF05755; P15535 CHOYP_LOC100866516.2.2 m.41731 sp B4GT1_MOUSE 46.691 272 142 1 87 355 122 393 1.17E-85 267 B4GT1_MOUSE reviewed "Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]" B4galt1 Ggtb Ggtb2 Mus musculus (Mouse) 399 acute inflammatory response [GO:0002526]; angiogenesis involved in wound healing [GO:0060055]; binding of sperm to zona pellucida [GO:0007339]; branching morphogenesis of an epithelial tube [GO:0048754]; cell adhesion [GO:0007155]; development of secondary sexual characteristics [GO:0045136]; epithelial cell development [GO:0002064]; extracellular matrix organization [GO:0030198]; galactose metabolic process [GO:0006012]; glycoprotein biosynthetic process [GO:0009101]; lactose biosynthetic process [GO:0005989]; leukocyte migration [GO:0050900]; mammary gland development [GO:0030879]; negative regulation of cell proliferation [GO:0008285]; oligosaccharide biosynthetic process [GO:0009312]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; regulation of acrosome reaction [GO:0060046]; regulation of cell proliferation [GO:0042127]; regulation of cellular component movement [GO:0051270]; wound healing [GO:0042060] GO:0000138; GO:0002064; GO:0002526; GO:0003831; GO:0003945; GO:0004461; GO:0005615; GO:0005794; GO:0005886; GO:0005989; GO:0006012; GO:0006486; GO:0006487; GO:0007155; GO:0007339; GO:0007341; GO:0008092; GO:0008285; GO:0008378; GO:0009101; GO:0009312; GO:0009897; GO:0009986; GO:0016020; GO:0016021; GO:0016323; GO:0030057; GO:0030112; GO:0030145; GO:0030175; GO:0030198; GO:0030879; GO:0031526; GO:0032580; GO:0035250; GO:0042060; GO:0042127; GO:0043065; GO:0045136; GO:0048754; GO:0050900; GO:0051270; GO:0060046; GO:0060054; GO:0060055; GO:0060058; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02709;PF13733; P16157 CHOYP_LOC755521.8.28 m.35243 sp ANK1_HUMAN 29.867 452 292 6 382 815 82 526 1.17E-46 185 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18488 CHOYP_LOC577702.1.1 m.30448 sp EMS_DROME 51.449 138 61 2 160 297 350 481 1.17E-37 143 EMS_DROME reviewed Homeotic protein empty spiracles ems E4 CG2988 Drosophila melanogaster (Fruit fly) 497 "anterior head segmentation [GO:0035288]; axonogenesis [GO:0007409]; brain development [GO:0007420]; brain segmentation [GO:0035284]; dendrite morphogenesis [GO:0048813]; embryonic development via the syncytial blastoderm [GO:0001700]; neuroblast development [GO:0014019]; open tracheal system development [GO:0007424]; pattern specification process [GO:0007389]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral cord development [GO:0007419]" GO:0000980; GO:0001158; GO:0001700; GO:0005634; GO:0006355; GO:0007389; GO:0007409; GO:0007419; GO:0007420; GO:0007424; GO:0010468; GO:0014019; GO:0035277; GO:0035284; GO:0035288; GO:0048813 0 0 0 PF00046; P20825 CHOYP_LOC580404.2.3 m.13462 sp POL2_DROME 39.056 466 267 8 563 1017 161 620 1.17E-95 330 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P41778 CHOYP_LOC100168368.1.1 m.18551 sp PBX1_MOUSE 67.448 384 64 6 36 395 39 385 1.17E-166 479 PBX1_MOUSE reviewed Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) Pbx1 Pbx-1 Mus musculus (Mouse) 430 adrenal gland development [GO:0030325]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic hemopoiesis [GO:0035162]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; embryonic skeletal system development [GO:0048706]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; organ morphogenesis [GO:0009887]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of cell proliferation [GO:0042127]; regulation of ossification [GO:0030278]; sex differentiation [GO:0007548]; spleen development [GO:0048536]; steroid biosynthetic process [GO:0006694]; thymus development [GO:0048538]; urogenital system development [GO:0001655] GO:0000978; GO:0001077; GO:0001655; GO:0001658; GO:0003677; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006694; GO:0007548; GO:0008284; GO:0009887; GO:0009952; GO:0009954; GO:0010971; GO:0030278; GO:0030325; GO:0030326; GO:0035162; GO:0042127; GO:0043433; GO:0043565; GO:0045665; GO:0045944; GO:0046982; GO:0048536; GO:0048538; GO:0048568; GO:0048706 0 0 0 PF00046;PF03792; P49013 CHOYP_LOC100634060.14.37 m.34467 sp FBP3_STRPU 54.335 173 79 0 1 173 179 351 1.17E-56 189 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P54922 CHOYP_BRAFLDRAFT_212086.4.11 m.42448 sp ADPRH_HUMAN 54.857 350 151 4 7 354 3 347 1.17E-130 385 ADPRH_HUMAN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Homo sapiens (Human) 357 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; P56812 CHOYP_LOC100367201.2.2 m.61573 sp PDCD5_MOUSE 57.48 127 49 1 10 136 1 122 1.17E-41 137 PDCD5_MOUSE reviewed Programmed cell death protein 5 (TF-1 cell apoptosis-related protein 19) (Protein TFAR19) Pdcd5 Tfar19 Mus musculus (Mouse) 126 apoptotic process [GO:0006915]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chaperone-mediated protein folding [GO:1903645]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of gene expression [GO:0010628]; positive regulation of protein import into mitochondrial outer membrane [GO:1903638]; positive regulation of release of cytochrome c from mitochondria [GO:0090200] GO:0003677; GO:0005634; GO:0005737; GO:0006915; GO:0008201; GO:0008285; GO:0010628; GO:0010698; GO:0043065; GO:0043280; GO:0048487; GO:0070062; GO:0071560; GO:0090200; GO:1903638; GO:1903645 0 0 0 PF01984; P59222 CHOYP_BRAFLDRAFT_224574.7.18 m.32600 sp SREC2_MOUSE 44.706 85 43 3 103 187 227 307 1.17E-11 66.2 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P59742 CHOYP_PHUM_PHUM323880.3.4 m.48488 sp NGB1_ONCMY 27.778 144 101 2 53 194 4 146 1.17E-15 73.9 NGB1_ONCMY reviewed Neuroglobin-1 ngb1 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 159 0 GO:0005344; GO:0005737; GO:0019825; GO:0020037; GO:0043204; GO:0046872 0 0 0 PF00042; Q06805 CHOYP_MEGF11.10.11 m.63709 sp TIE1_BOVIN 38.095 63 37 2 192 254 210 270 1.17E-07 56.2 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q07263 CHOYP_LOC100691407.1.1 m.38614 sp ACHA3_BOVIN 30.861 337 220 5 27 358 25 353 1.17E-50 180 ACHA3_BOVIN reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Bos taurus (Bovine) 495 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; Q08999 CHOYP_RBL2.1.1 m.64017 sp RBL2_HUMAN 54.348 92 42 0 1 92 253 344 1.17E-28 111 RBL2_HUMAN reviewed Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) RBL2 RB2 Homo sapiens (Human) 1139 "covalent chromatin modification [GO:0016569]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of gene expression [GO:0010629]; regulation of lipid kinase activity [GO:0043550]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0005667; GO:0005730; GO:0005737; GO:0006351; GO:0006357; GO:0006977; GO:0010629; GO:0016569; GO:0043550; GO:0070062; GO:1990841 0 0 0 PF11934;PF01858;PF01857; Q0E908 CHOYP_BRAFLDRAFT_92367.1.4 m.29492 sp HIL_DROME 24.324 481 306 16 56 512 333 779 1.17E-30 134 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q0IHI4 CHOYP_PPIB.2.4 m.40020 sp TIPIN_XENLA 34.146 123 72 4 6 128 10 123 1.17E-10 62 TIPIN_XENLA reviewed TIMELESS-interacting protein (XTipin) tipin Xenopus laevis (African clawed frog) 360 cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint [GO:0000076]; intra-S DNA damage checkpoint [GO:0031573]; mitotic nuclear division [GO:0007067]; positive regulation of cell proliferation [GO:0008284]; replication fork protection [GO:0048478] GO:0000076; GO:0000790; GO:0005634; GO:0005737; GO:0007067; GO:0008284; GO:0031573; GO:0044770; GO:0048478; GO:0051301 0 0 0 PF07962; Q0MQI9 CHOYP_BRAFLDRAFT_115771.2.2 m.30817 sp NDUV2_PANTR 67.094 234 70 3 181 412 21 249 1.17E-111 330 NDUV2_PANTR reviewed "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit)" NDUFV2 Pan troglodytes (Chimpanzee) 249 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" GO:0005747; GO:0006120; GO:0008137; GO:0046872; GO:0051537 0 0 0 0 Q0V7M8 CHOYP_F167A.1.2 m.4553 sp F167A_BOVIN 37.766 188 77 6 81 233 29 211 1.17E-25 102 F167A_BOVIN reviewed Protein FAM167A FAM167A Bos taurus (Bovine) 211 0 0 0 0 0 PF11652; Q0V9E9 CHOYP_SETD8.1.3 m.9518 sp KMT5A_XENTR 60.541 185 72 1 77 261 152 335 1.17E-75 236 KMT5A_XENTR reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (SET domain-containing protein 8) kmt5a setd8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 336 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007067; GO:0018024; GO:0051301 0 0 0 PF00856; Q0VC16 CHOYP_LOC100373461.1.2 m.30015 sp MIA3_BOVIN 28.442 552 338 15 1033 1552 1145 1671 1.17E-38 162 MIA3_BOVIN reviewed Melanoma inhibitory activity protein 3 (Transport and Golgi organization protein 1) MIA3 TANGO1 Bos taurus (Bovine) 1905 cargo loading into COPII-coated vesicle [GO:0090110]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031] GO:0000139; GO:0005789; GO:0006887; GO:0006888; GO:0015031; GO:0016021; GO:0042953; GO:0042954; GO:0070971; GO:0090110 0 0 0 PF07653; Q10984 CHOYP_FUT1.2.2 m.64458 sp FUT2_RAT 26.994 326 220 6 7 324 12 327 1.17E-34 132 FUT2_RAT reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha 1,2-fucosyltransferase) (Alpha 1,2-fucosyltransferase B) (Alpha 1-2 fucosyltransferase) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (Secretor blood group alpha-2-fucosyltransferase)" Fut2 Ftb Sec1 Rattus norvegicus (Rat) 354 protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q16739 CHOYP_SMP_160210.1.1 m.23966 sp CEGT_HUMAN 41.221 393 228 3 9 401 4 393 1.17E-106 323 CEGT_HUMAN reviewed Ceramide glucosyltransferase (EC 2.4.1.80) (GLCT-1) (Glucosylceramide synthase) (GCS) (UDP-glucose ceramide glucosyltransferase) (UDP-glucose:N-acylsphingosine D-glucosyltransferase) UGCG Homo sapiens (Human) 394 epidermis development [GO:0008544]; glucosylceramide biosynthetic process [GO:0006679]; glycosphingolipid biosynthetic process [GO:0006688]; glycosphingolipid metabolic process [GO:0006687]; positive regulation of protein targeting to mitochondrion [GO:1903955] GO:0000139; GO:0006679; GO:0006687; GO:0006688; GO:0008120; GO:0008544; GO:0016020; GO:0016021; GO:1903955 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF13506; Q16831 CHOYP_LOC100876012.1.1 m.8280 sp UPP1_HUMAN 51.418 282 134 1 26 307 29 307 1.17E-95 288 UPP1_HUMAN reviewed Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) UPP1 UP Homo sapiens (Human) 310 cellular response to glucose starvation [GO:0042149]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide catabolic process [GO:0009166]; pyrimidine nucleoside catabolic process [GO:0046135]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218] GO:0004850; GO:0005829; GO:0006139; GO:0006218; GO:0009166; GO:0042149; GO:0043097; GO:0044206; GO:0046135 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. {ECO:0000305}. 0 0 PF01048; Q1ZXD6 CHOYP_TRIADDRAFT_61416.1.1 m.26099 sp ROCO5_DICDI 35.484 93 43 4 146 238 1337 1412 1.17E-08 59.3 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q21828 CHOYP_CBG18071.1.1 m.63498 sp MPC1_CAEEL 56.881 109 46 1 5 113 19 126 1.17E-41 137 MPC1_CAEEL reviewed Probable mitochondrial pyruvate carrier 1 (MPC1) R07E5.13 Caenorhabditis elegans 137 mitochondrial pyruvate transport [GO:0006850] GO:0005743; GO:0006850; GO:0016021 0 0 0 PF03650; Q3SZZ7 CHOYP_LOC100367879.3.3 m.58997 sp FGL1_BOVIN 40.769 260 129 6 84 322 49 304 1.17E-50 173 FGL1_BOVIN reviewed Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) 312 0 GO:0070062 0 0 0 PF00147; Q460N5 CHOYP_PARP14.16.22 m.53025 sp PAR14_HUMAN 31.136 819 529 18 296 1109 1012 1800 1.17E-111 386 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4UMH6 CHOYP_TVAG_227760.1.4 m.20880 sp Y381_RICFE 35.86 343 193 13 4 325 624 960 1.17E-27 117 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q505G8 CHOYP_IKZF3.1.2 m.56068 sp ZN827_MOUSE 47.541 61 30 2 283 342 369 428 1.17E-08 60.5 ZN827_MOUSE reviewed Zinc finger protein 827 Znf827 Zfp827 Mus musculus (Mouse) 1078 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q5F416 CHOYP_TIPIN.1.2 m.4885 sp TIPIN_CHICK 59.302 86 34 1 53 138 54 138 1.17E-30 114 TIPIN_CHICK reviewed TIMELESS-interacting protein TIPIN RCJMB04_3n6 Gallus gallus (Chicken) 283 cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint [GO:0000076]; intra-S DNA damage checkpoint [GO:0031573]; mitotic nuclear division [GO:0007067]; positive regulation of cell proliferation [GO:0008284]; replication fork protection [GO:0048478] GO:0000076; GO:0000790; GO:0005634; GO:0005737; GO:0007067; GO:0008284; GO:0031573; GO:0044770; GO:0048478; GO:0051301 0 0 0 PF07962; Q5FVM5 CHOYP_LOC100371102.1.1 m.65616 sp CR3L3_RAT 51.099 182 76 5 325 504 208 378 1.17E-43 165 CR3L3_RAT reviewed Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3] Creb3l3 Rattus norvegicus (Rat) 470 endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440] GO:0000977; GO:0001228; GO:0005634; GO:0005789; GO:0016021; GO:0030968; GO:0035497; GO:1990440 0 0 0 PF00170; Q5R4J5 CHOYP_LOC100371008.1.1 m.41600 sp SYT1_PONAB 30.515 272 181 6 424 693 141 406 1.17E-33 137 SYT1_PONAB reviewed Synaptotagmin-1 (Synaptotagmin I) (SytI) SYT1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 419 cell differentiation [GO:0030154] GO:0016021; GO:0030054; GO:0030154; GO:0030672; GO:0042584; GO:0046872 0 0 0 PF00168; Q5R833 CHOYP_LOC100366428.1.1 m.3742 sp ACO13_PONAB 40 120 72 0 26 145 19 138 1.17E-27 103 ACO13_PONAB reviewed "Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Thioesterase superfamily member 2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]" ACOT13 THEM2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 140 0 GO:0005634; GO:0005739; GO:0005819; GO:0005829; GO:0016787 0 0 0 PF03061; Q5R9L9 CHOYP_POMP.2.2 m.62437 sp POMP_PONAB 47.899 119 62 0 42 160 23 141 1.17E-32 116 POMP_PONAB reviewed Proteasome maturation protein (Proteassemblin) POMP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 141 proteasome assembly [GO:0043248] GO:0005634; GO:0005783; GO:0005829; GO:0031090; GO:0043248 0 0 0 0 Q5TYW6 CHOYP_BRAFLDRAFT_121507.1.2 m.30603 sp RSPH9_DANRE 55.957 277 120 2 1 275 1 277 1.17E-113 331 RSPH9_DANRE reviewed Radial spoke head protein 9 homolog rsph9 si:ch211-117l16.2 zgc:123211 Danio rerio (Zebrafish) (Brachydanio rerio) 277 axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; motile cilium assembly [GO:0044458] GO:0003341; GO:0005737; GO:0005930; GO:0031514; GO:0035082; GO:0044458; GO:0060294 0 0 0 PF04712; Q6DIY8 CHOYP_LOC100747417.1.1 m.29664 sp M17L2_XENTR 33.023 215 137 3 1 215 2 209 1.17E-34 125 M17L2_XENTR reviewed Mpv17-like protein 2 mpv17l2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 222 0 GO:0005743; GO:0016021 0 0 0 PF04117; Q6ICG8 CHOYP_contig_018516 m.21712 sp WBP2L_HUMAN 49.231 65 33 0 11 75 213 277 1.17E-06 50.1 WBP2L_HUMAN reviewed Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like) WBP2NL PAWP Homo sapiens (Human) 309 egg activation [GO:0007343]; female pronucleus assembly [GO:0035038]; male pronucleus assembly [GO:0035039]; meiotic cell cycle [GO:0051321] GO:0007343; GO:0033011; GO:0035038; GO:0035039; GO:0050699; GO:0051321 0 0 0 PF02893; Q6IR74 CHOYP_BRAFLDRAFT_127837.1.1 m.50015 sp CTL1_XENLA 35.484 651 382 14 10 647 5 630 1.17E-131 404 CTL1_XENLA reviewed Choline transporter-like protein 1 (Solute carrier family 44 member 1) slc44a1 ctl1 Xenopus laevis (African clawed frog) 651 0 GO:0016021 0 0 0 PF04515; Q6P360 CHOYP_LOC100471656.2.2 m.34266 sp RN121_XENTR 65.979 291 99 0 52 342 20 310 1.17E-152 435 RN121_XENTR reviewed RING finger protein 121 rnf121 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 327 endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; neuronal action potential [GO:0019228]; protein localization to plasma membrane [GO:0072659]; regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903069]; thigmotaxis [GO:0001966] GO:0000139; GO:0001966; GO:0005789; GO:0008270; GO:0016021; GO:0019228; GO:0030433; GO:0030968; GO:0061630; GO:0072659; GO:1903069 0 0 0 0 Q6P5J6 CHOYP_LOC100546563.1.1 m.16548 sp LRC42_DANRE 33.84 263 155 6 25 273 77 334 1.17E-36 139 LRC42_DANRE reviewed Leucine-rich repeat-containing protein 42 lrrc42 si:dkey-181m9.2 Danio rerio (Zebrafish) (Brachydanio rerio) 407 0 0 0 0 0 0 Q6ZQ12 CHOYP_LOC583607.4.4 m.54241 sp NINL_MOUSE 27.945 798 443 26 169 912 99 818 1.17E-58 226 NINL_MOUSE reviewed Ninein-like protein Ninl Kiaa0980 Nlp Mus musculus (Mouse) 1394 microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005509; GO:0005737; GO:0005815; GO:0005856; GO:0005874 0 0 0 PF13499; Q76KX8 CHOYP_ZNF184.1.1 m.59420 sp ZN534_HUMAN 33.918 171 96 5 466 627 474 636 1.17E-20 100 ZN534_HUMAN reviewed Zinc finger protein 534 (KRAB domain only protein 3) ZNF534 KRBO3 Homo sapiens (Human) 674 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q76LC6 CHOYP_BRAFLDRAFT_80496.10.10 m.60408 sp RBM24_DANRE 76.316 114 26 1 6 118 4 117 1.17E-56 179 RBM24_DANRE reviewed RNA-binding protein 24 (RNA-binding motif protein 24) (RNA-binding protein SEB-4) rbm24 Danio rerio (Zebrafish) (Brachydanio rerio) 230 atrial cardiac muscle tissue development [GO:0003228]; cardiovascular system development [GO:0072358]; cell differentiation [GO:0030154]; embryonic neurocranium morphogenesis [GO:0048702]; heart looping [GO:0001947]; mRNA processing [GO:0006397]; regulation of mRNA stability [GO:0043488]; regulation of myotube differentiation [GO:0010830]; regulation of sarcomere organization [GO:0060297]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756] GO:0000166; GO:0001756; GO:0001947; GO:0003228; GO:0003730; GO:0005634; GO:0005737; GO:0006397; GO:0007519; GO:0010830; GO:0030154; GO:0043488; GO:0048702; GO:0060297; GO:0072358 0 0 0 PF00076; Q86TZ1 CHOYP_LOC587791.2.3 m.33887 sp TTC6_HUMAN 46.465 396 212 0 1768 2163 121 516 1.17E-114 378 TTC6_HUMAN reviewed Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 Homo sapiens (Human) 520 0 0 0 0 0 PF00515;PF13181; Q86YD5 CHOYP_DFA_07312.1.2 m.9981 sp LRAD3_HUMAN 28.788 264 146 11 93 348 51 280 1.17E-11 70.1 LRAD3_HUMAN reviewed Low-density lipoprotein receptor class A domain-containing protein 3 LDLRAD3 Homo sapiens (Human) 345 receptor-mediated endocytosis [GO:0006898]; regulation of protein processing [GO:0070613] GO:0001540; GO:0005886; GO:0006898; GO:0016021; GO:0030054; GO:0070613 0 0 0 PF00057; Q8BZG5 CHOYP_RRNAD.1.1 m.15888 sp RRNAD_MOUSE 47.273 220 105 4 440 658 251 460 1.17E-50 186 RRNAD_MOUSE reviewed Protein RRNAD1 Rrnad1 Mus musculus (Mouse) 475 0 GO:0016021 0 0 0 PF13679; Q8C525 CHOYP_LOC100370446.9.12 m.45629 sp M21D2_MOUSE 25.444 169 117 5 10 177 162 322 1.17E-08 60.5 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8IZR5 CHOYP_CRE_23922.1.1 m.63463 sp CKLF4_HUMAN 30.392 204 130 7 2 197 24 223 1.17E-13 70.5 CKLF4_HUMAN reviewed CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4) CMTM4 CKLFSF4 Homo sapiens (Human) 234 chemotaxis [GO:0006935] GO:0005615; GO:0006935; GO:0016021 0 0 0 PF01284; Q8K3P0 CHOYP_BRAFLDRAFT_290887.1.1 m.29305 sp DR9C7_MOUSE 37.736 318 186 4 32 348 1 307 1.17E-65 213 DR9C7_MOUSE reviewed Short-chain dehydrogenase/reductase family 9C member 7 (EC 1.1.1.-) (Orphan short-chain dehydrogenase/reductase) (SDR-O) (RDH-S) Sdr9c7 Rdhs Sdro Mus musculus (Mouse) 313 oxidation-reduction process [GO:0055114] GO:0004745; GO:0005730; GO:0005737; GO:0055114 0 0 0 PF00106; Q8WXG9 CHOYP_GPR98.1.5 m.9886 sp GPR98_HUMAN 33.525 868 547 12 2 861 826 1671 1.17E-139 462 GPR98_HUMAN reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 Homo sapiens (Human) 6306 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; maintenance of organ identity [GO:0048496]; nervous system development [GO:0007399]; neurological system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; single organismal cell-cell adhesion [GO:0016337]; visual perception [GO:0007601] GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0007166; GO:0007186; GO:0007399; GO:0007601; GO:0007605; GO:0009986; GO:0016020; GO:0016021; GO:0016337; GO:0032420; GO:0043235; GO:0045202; GO:0045494; GO:0048496; GO:0050877; GO:0050953; GO:0070062 0 0 0 PF00002;PF03160;PF03736; Q96MM6 CHOYP_HS12B.11.14 m.59914 sp HS12B_HUMAN 34.615 624 338 15 1 563 70 684 1.17E-110 348 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9CZB3 CHOYP_LOC101161000.1.1 m.6327 sp THUM2_MOUSE 41.899 179 100 1 3 181 240 414 1.17E-43 160 THUM2_MOUSE reviewed THUMP domain-containing protein 2 Thumpd2 Mus musculus (Mouse) 528 tRNA methylation [GO:0030488] GO:0000049; GO:0016423; GO:0030488 0 0 0 PF02926;PF01170; Q9D287 CHOYP_BRAFLDRAFT_115639.1.1 m.11373 sp SPF27_MOUSE 68.75 208 65 0 1 208 7 214 1.17E-98 288 SPF27_MOUSE reviewed Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2 homolog) (DNA amplified in mammary carcinoma 1 protein) Bcas2 Dam1 Mus musculus (Mouse) 225 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0000974; GO:0005634; GO:0005662; GO:0005681; GO:0005730; GO:0030054; GO:0071011; GO:0071012; GO:0071013 0 0 0 PF05700; Q9DFQ7 CHOYP_RL24.1.9 m.304 sp RL24_GILMI 68.421 133 35 2 42 170 28 157 1.17E-49 160 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9ESN6 CHOYP_LOC100373888.3.9 m.32833 sp TRIM2_MOUSE 24.473 237 151 8 299 520 484 707 1.17E-12 74.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GJU1 CHOYP_LOC579893.1.1 m.7575 sp DRD2_CANLF 19.022 368 273 7 31 384 42 398 1.17E-08 60.5 DRD2_CANLF reviewed D(2) dopamine receptor (Dopamine D2 receptor) DRD2 Canis lupus familiaris (Dog) (Canis familiaris) 443 "adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482]; regulation of dopamine secretion [GO:0014059]; regulation of potassium ion transport [GO:0043266]; response to drug [GO:0042493]; response to toxic substance [GO:0009636]; synaptic transmission, dopaminergic [GO:0001963]" GO:0001591; GO:0001963; GO:0005887; GO:0007194; GO:0007195; GO:0009636; GO:0014059; GO:0030672; GO:0035240; GO:0042493; GO:0043266; GO:0048148; GO:0048149; GO:0051481; GO:0051482; GO:0051967; GO:0060158; GO:1901386 0 0 0 PF00001; Q9H8W5 CHOYP_LOC100370907.1.3 m.3187 sp TRI45_HUMAN 24.359 234 169 8 4 232 127 357 1.17E-07 55.8 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9H903 CHOYP_MTHFD2L.1.1 m.1891 sp MTD2L_HUMAN 59.184 196 73 2 37 232 153 341 1.17E-70 222 MTD2L_HUMAN reviewed Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] MTHFD2L Homo sapiens (Human) 347 10-formyltetrahydrofolate metabolic process [GO:0009256]; folic acid-containing compound biosynthetic process [GO:0009396]; folic acid metabolic process [GO:0046655]; histidine biosynthetic process [GO:0000105]; methionine biosynthetic process [GO:0009086]; one-carbon metabolic process [GO:0006730]; purine nucleotide biosynthetic process [GO:0006164]; tetrahydrofolate interconversion [GO:0035999] GO:0000105; GO:0004477; GO:0004487; GO:0004488; GO:0005739; GO:0005743; GO:0005759; GO:0006164; GO:0006730; GO:0009086; GO:0009256; GO:0009396; GO:0035999; GO:0046655 PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. 0 0 PF00763;PF02882; Q9HCF6 CHOYP_TRPM2.7.12 m.45909 sp TRPM3_HUMAN 31.02 245 153 6 1 243 958 1188 1.17E-29 121 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9JHA8 CHOYP_LOC565211.1.2 m.34982 sp VWA7_MOUSE 28.169 568 346 20 71 625 86 604 1.17E-39 162 VWA7_MOUSE reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) 891 0 GO:0005576 0 0 0 0 Q9JHL4 CHOYP_LOC100374625.1.1 m.48419 sp DBNL_RAT 65 80 21 2 182 261 363 435 1.17E-27 113 DBNL_RAT reviewed Drebrin-like protein (Actin-binding protein 1) (Abp1) (SH3 domain-containing protein 7) Dbnl Sh3p7 Rattus norvegicus (Rat) 436 adaptive immune response [GO:0002250]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898]; ruffle assembly [GO:0097178]; synapse assembly [GO:0007416] GO:0000139; GO:0001726; GO:0002102; GO:0002250; GO:0003779; GO:0005737; GO:0005769; GO:0005829; GO:0005886; GO:0005938; GO:0006898; GO:0007416; GO:0008022; GO:0014069; GO:0016601; GO:0030027; GO:0030054; GO:0030425; GO:0030665; GO:0048812; GO:0051015; GO:0070062; GO:0071800; GO:0097178 0 0 0 PF00241;PF14604; Q9NXS2 CHOYP_BRAFLDRAFT_265991.1.1 m.58765 sp QPCTL_HUMAN 41.304 92 52 1 36 125 81 172 1.17E-14 74.3 QPCTL_HUMAN reviewed Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5) (Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC) QPCTL Homo sapiens (Human) 382 "peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]" GO:0000139; GO:0005794; GO:0008270; GO:0016020; GO:0016021; GO:0016603; GO:0017186 0 0 0 PF04389; Q9P2F6 CHOYP_LOC100118685.1.1 m.58142 sp RHG20_HUMAN 27.094 203 141 2 27 224 363 563 1.17E-16 87 RHG20_HUMAN reviewed Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) 1191 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00788;PF00620; Q9UDY8 CHOYP_MALT1.1.1 m.53909 sp MALT1_HUMAN 30.579 605 360 17 261 819 129 719 1.17E-66 241 MALT1_HUMAN reviewed Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) MALT1 MLT Homo sapiens (Human) 824 activation of NF-kappaB-inducing kinase activity [GO:0007250]; B-1 B cell differentiation [GO:0001923]; defense response [GO:0006952]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; nuclear export [GO:0051168]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell cytokine production [GO:0002726]; protein oligomerization [GO:0051259]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of T cell receptor signaling pathway [GO:0050856]; response to fungus [GO:0009620]; response to molecule of bacterial origin [GO:0002237]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852] GO:0001923; GO:0002223; GO:0002237; GO:0002726; GO:0004197; GO:0004842; GO:0004871; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0006508; GO:0006952; GO:0007250; GO:0008233; GO:0009620; GO:0031398; GO:0032449; GO:0032743; GO:0038095; GO:0042098; GO:0042981; GO:0043066; GO:0043123; GO:0043234; GO:0043621; GO:0045087; GO:0048471; GO:0050852; GO:0050856; GO:0050870; GO:0051092; GO:0051168; GO:0051259 0 0 0 PF13895; Q9W6Z2 CHOYP_PHUM_PHUM375280.1.2 m.23797 sp TBPL1_XENLA 62.687 134 50 0 2 135 47 180 1.17E-56 180 TBPL1_XENLA reviewed TATA box-binding protein-like protein 1 (TBP-like protein 1) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (xlTLF) tbpl1 tlf trf2 Xenopus laevis (African clawed frog) 186 "DNA-templated transcription, initiation [GO:0006352]; embryo development [GO:0009790]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003677; GO:0005634; GO:0005737; GO:0006352; GO:0006355; GO:0006366; GO:0009790 0 0 cd04517; PF00352; Q9Y4A5 CHOYP_TRRAP.1.2 m.339 sp TRRAP_HUMAN 61.571 471 172 4 10 479 13 475 1.17E-176 564 TRRAP_HUMAN reviewed Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) TRRAP PAF400 Homo sapiens (Human) 3859 "beta-catenin-TCF complex assembly [GO:1904837]; DNA repair [GO:0006281]; histone acetylation [GO:0016573]; histone deubiquitination [GO:0016578]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000125; GO:0000812; GO:0003712; GO:0005634; GO:0005654; GO:0005794; GO:0006281; GO:0006351; GO:0006355; GO:0016301; GO:0016573; GO:0016578; GO:0030914; GO:0033276; GO:0035267; GO:0043967; GO:0043968; GO:1904837 0 0 0 PF02259;PF00454; Q9Y5Q9 CHOYP_TF3C3.3.3 m.55782 sp TF3C3_HUMAN 47.234 235 121 1 158 392 133 364 1.17E-67 233 TF3C3_HUMAN reviewed General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) 886 "5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase III promoter [GO:0006383]; tRNA transcription from RNA polymerase III promoter [GO:0042797]" GO:0000127; GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006383; GO:0031965; GO:0042791; GO:0042797 0 0 0 PF13181; A0JM12 CHOYP_PHUM_PHUM049590.1.4 m.14202 sp MEG10_XENTR 40.909 132 68 6 36 166 267 389 1.18E-17 84 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AX52 CHOYP_LOC100486063.7.9 m.53745 sp CO6A4_MOUSE 21.138 861 567 28 364 1162 430 1240 1.18E-31 139 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A2RUS2 CHOYP_NEMVEDRAFT_V1G100491.1.1 m.7383 sp DEND3_HUMAN 28.342 187 114 9 1 178 931 1106 1.18E-12 68.9 DEND3_HUMAN reviewed DENN domain-containing protein 3 DENND3 KIAA0870 Homo sapiens (Human) 1198 cellular protein catabolic process [GO:0044257]; endosome to lysosome transport [GO:0008333] GO:0005622; GO:0008333; GO:0017112; GO:0044257 0 0 0 PF02141; A2VD01 CHOYP_BRAFLDRAFT_203393.1.2 m.16759 sp CR3L2_XENLA 41.35 474 215 20 8 457 14 448 1.18E-59 209 CR3L2_XENLA reviewed Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] creb3l2 Xenopus laevis (African clawed frog) 525 "cartilage development [GO:0051216]; chondrocyte differentiation [GO:0002062]; endoplasmic reticulum unfolded protein response [GO:0030968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to endoplasmic reticulum stress [GO:0034976]; transcription, DNA-templated [GO:0006351]" GO:0002062; GO:0003700; GO:0005634; GO:0005783; GO:0005789; GO:0006351; GO:0016021; GO:0030968; GO:0034976; GO:0035497; GO:0043565; GO:0044212; GO:0045944; GO:0051216 0 0 0 PF00170; A4IGL7 CHOYP_LOC100908663.1.1 m.62468 sp PXDN_XENTR 22.903 310 186 12 20 326 238 497 1.18E-07 58.5 PXDN_XENTR reviewed Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1457 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF03098;PF07679;PF13855;PF00093; A4QN56 CHOYP_LOC100771202.2.2 m.56010 sp MFS4B_DANRE 25.263 475 315 14 53 518 76 519 1.18E-32 135 MFS4B_DANRE reviewed Sodium-dependent glucose transporter 1 (Major facilitator superfamily domain-containing protein 4B) mfsd4b naglt1 zgc:162161 Danio rerio (Zebrafish) (Brachydanio rerio) 594 carbohydrate transport [GO:0008643]; sodium ion transport [GO:0006814] GO:0006814; GO:0008643; GO:0015293; GO:0016021; GO:0016324 0 0 cd06174; PF07690; A6H7C2 CHOYP_PEX3.1.1 m.32135 sp PEX3_BOVIN 44.416 385 183 8 1 371 1 368 1.18E-105 318 PEX3_BOVIN reviewed Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3) PEX3 Bos taurus (Bovine) 373 amino acid transmembrane transport [GO:0003333]; peroxisome organization [GO:0007031] GO:0003333; GO:0005779; GO:0007031; GO:0015171 0 0 0 PF04882; A6QP05 CHOYP_BRAFLDRAFT_114204.1.1 m.15168 sp DHR12_BOVIN 60.815 319 123 2 1 319 1 317 1.18E-141 405 DHR12_BOVIN reviewed Dehydrogenase/reductase SDR family member 12 (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 40C member 1) DHRS12 SDR40C1 Bos taurus (Bovine) 317 0 GO:0016491 0 0 0 PF00106; B2RYG8 CHOYP_ELP6.1.1 m.35681 sp ELP6_RAT 37.079 267 152 5 19 273 4 266 1.18E-51 172 ELP6_RAT reviewed Elongator complex protein 6 (Protein TMEM103) Elp6 Tmem103 Rattus norvegicus (Rat) 266 "positive regulation of cell migration [GO:0030335]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006357; GO:0030335; GO:0033588 0 0 0 PF09807; B3EWZ5 CHOYP_LOC580670.2.6 m.4945 sp MLRP1_ACRMI 33.742 326 201 10 19 329 927 1252 1.18E-35 141 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; F6PHZ6 CHOYP_LOC100634891.1.1 m.11488 sp FKBP6_HORSE 34.098 305 193 4 80 384 9 305 1.18E-49 175 FKBP6_HORSE reviewed Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (Inactive PPIase FKBP6) (36 kDa FK506-binding protein) (FK506-binding protein 6) (FKBP-6) (Immunophilin FKBP36) FKBP6 FKBP36 Equus caballus (Horse) 316 cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; meiotic nuclear division [GO:0007126]; piRNA metabolic process [GO:0034587]; protein folding [GO:0006457]; spermatogenesis [GO:0007283] GO:0000795; GO:0003755; GO:0005528; GO:0005737; GO:0005789; GO:0005829; GO:0006457; GO:0007126; GO:0007283; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:0051879; GO:0061077 0 0 0 PF00254; O15050 CHOYP_TRANK1.9.9 m.60209 sp TRNK1_HUMAN 28.376 511 316 14 887 1354 370 873 1.18E-38 162 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O70165 CHOYP_FGL1.6.6 m.52536 sp FCN1_MOUSE 43.363 226 115 6 90 310 115 332 1.18E-52 179 FCN1_MOUSE reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Mus musculus (Mouse) 334 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 secretion [GO:2000484]" GO:0001867; GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0046872; GO:0097367; GO:2000484 0 0 0 PF01391;PF00147; O70277 CHOYP_LOC100369333.9.32 m.32507 sp TRIM3_RAT 24.336 226 141 9 341 551 534 744 1.18E-07 58.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O93209 CHOYP_LOC100497597.1.1 m.31908 sp POL_FFV 25.991 227 142 9 67 293 197 397 1.18E-06 53.5 POL_FFV reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Feline foamy virus (FFV) (Feline syncytial virus) 1156 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; P08938 CHOYP_LOC100554369.1.1 m.19205 sp PURP_CHICK 31.818 198 105 12 14 196 2 184 1.18E-17 80.5 PURP_CHICK reviewed Purpurin 0 Gallus gallus (Chicken) 196 0 GO:0005215; GO:0016918; GO:0019841; GO:0033165 0 0 0 PF00061; P10155 CHOYP_TROVE2.1.1 m.63532 sp RO60_HUMAN 41.297 293 152 6 56 346 10 284 1.18E-69 229 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P12001 CHOYP_LOC100560334.3.3 m.50400 sp RL18_RAT 72.832 173 47 0 15 187 1 173 1.18E-92 271 RL18_RAT reviewed 60S ribosomal protein L18 Rpl18 Rattus norvegicus (Rat) 188 liver regeneration [GO:0097421]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0097421 0 0 0 PF17135; P16157 CHOYP_TVAG_020440.7.21 m.21058 sp ANK1_HUMAN 36.765 340 215 0 7 346 237 576 1.18E-59 211 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17439 CHOYP_GLCM.2.3 m.40511 sp GLCM_MOUSE 46.906 501 208 8 44 493 19 512 1.18E-155 456 GLCM_MOUSE reviewed Glucosylceramidase (EC 3.2.1.45) (Acid beta-glucosidase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) Gba Mus musculus (Mouse) 515 carbohydrate metabolic process [GO:0005975]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; ceramide biosynthetic process [GO:0046513]; glucosylceramide catabolic process [GO:0006680]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MAP kinase activity [GO:0043407]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of proteolysis involved in cellular protein catabolic process [GO:1903052]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of water loss via skin [GO:0033561]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to pH [GO:0009268]; response to testosterone [GO:0033574]; response to thyroid hormone [GO:0097066]; skin morphogenesis [GO:0043589]; sphingosine biosynthetic process [GO:0046512]; termination of signal transduction [GO:0023021] GO:0004348; GO:0005102; GO:0005615; GO:0005765; GO:0005975; GO:0006680; GO:0009267; GO:0009268; GO:0016239; GO:0016787; GO:0023021; GO:0032434; GO:0032715; GO:0033561; GO:0033574; GO:0035307; GO:0043202; GO:0043407; GO:0043589; GO:0043627; GO:0046512; GO:0046513; GO:0051384; GO:0070062; GO:0071356; GO:0097066; GO:1903052 0 0 0 PF02055;PF17189; P18172 CHOYP_GMCOX1.1.1 m.61183 sp DHGL_DROPS 39.474 570 302 12 68 623 65 605 1.18E-118 369 DHGL_DROPS reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) 625 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; P21158 CHOYP_LOC100377198.1.1 m.14640 sp CSGA_MYXXA 35.976 164 95 2 95 258 13 166 1.18E-31 117 CSGA_MYXXA reviewed C-factor (C signal) csgA spoC Myxococcus xanthus 166 sporulation resulting in formation of a cellular spore [GO:0030435] GO:0005576; GO:0030435 0 0 0 PF00106; P22105 CHOYP_LOC100705113.1.2 m.42734 sp TENX_HUMAN 31.28 211 87 11 144 332 326 500 1.18E-13 77.4 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P24733 CHOYP_ISCW_ISCW001340.1.1 m.1984 sp MYS_ARGIR 60.484 124 49 0 7 130 1316 1439 1.18E-39 145 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P27473 CHOYP_BRAFLDRAFT_99019.5.8 m.41284 sp IFI44_PANTR 28.173 323 176 11 14 326 7 283 1.18E-21 98.2 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P46872 CHOYP_LOC100549843.1.1 m.67003 sp KRP85_STRPU 70.588 119 33 1 1 119 1 117 1.18E-51 176 KRP85_STRPU reviewed Kinesin-II 85 kDa subunit (KRP-85/95 85 kDa subunit) KRP85 Strongylocentrotus purpuratus (Purple sea urchin) 699 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF00225; P49395 CHOYP_RS3A.5.15 m.18769 sp RS3A_APLCA 79.024 205 40 1 30 231 61 265 1.18E-116 336 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P53804 CHOYP_LOC100366748.1.1 m.15072 sp TTC3_HUMAN 31.699 306 202 4 594 897 490 790 1.18E-35 153 TTC3_HUMAN reviewed E3 ubiquitin-protein ligase TTC3 (EC 6.3.2.-) (Protein DCRR1) (RING finger protein 105) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) TTC3 DCRR1 RNF105 TPRD Homo sapiens (Human) 2025 protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004842; GO:0005634; GO:0005730; GO:0005737; GO:0006511; GO:0008270; GO:0016874; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; P54278 CHOYP_PMS2.1.1 m.16450 sp PMS2_HUMAN 55.157 446 188 4 25 462 12 453 1.18E-161 499 PMS2_HUMAN reviewed Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2) PMS2 PMSL2 Homo sapiens (Human) 862 mismatch repair [GO:0006298]; response to drug [GO:0042493]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0003677; GO:0004519; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006298; GO:0015630; GO:0016446; GO:0016887; GO:0032138; GO:0032389; GO:0042493 0 0 0 PF01119;PF08676; P57078 CHOYP_LOC100891279.1.1 m.41005 sp RIPK4_HUMAN 35 100 58 3 47 145 578 671 1.18E-08 57 RIPK4_HUMAN reviewed Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) RIPK4 ANKRD3 DIK Homo sapiens (Human) 832 morphogenesis of an epithelium [GO:0002009]; positive regulation of NF-kappaB transcription factor activity [GO:0051092] GO:0002009; GO:0004674; GO:0005524; GO:0005737; GO:0016020; GO:0051092 0 0 0 PF12796;PF00069; P82596 CHOYP_PLC.2.5 m.5277 sp PLC_HALLA 41.085 129 74 2 16 143 1 128 1.18E-25 98.2 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q05940 CHOYP_LOC659437.1.1 m.29499 sp VMAT2_HUMAN 51.23 244 106 2 16 253 12 248 1.18E-67 220 VMAT2_HUMAN reviewed Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) SLC18A2 SVMT VMAT2 Homo sapiens (Human) 514 aging [GO:0007568]; aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; cellular response to ammonium ion [GO:0071242]; cellular response to drug [GO:0035690]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; endocytic recycling [GO:0032456]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; negative regulation of neurotransmitter transport [GO:0051589]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter secretion [GO:0007269]; post-embryonic development [GO:0009791]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; response to corticosterone [GO:0051412]; response to herbicide [GO:0009635]; response to starvation [GO:0042594]; response to zinc ion [GO:0010043]; sequestering of neurotransmitter [GO:0042137] GO:0001975; GO:0005275; GO:0005886; GO:0005887; GO:0007268; GO:0007269; GO:0007568; GO:0007626; GO:0008021; GO:0008144; GO:0008504; GO:0009635; GO:0009791; GO:0010043; GO:0015222; GO:0015842; GO:0015844; GO:0015872; GO:0016020; GO:0030073; GO:0030672; GO:0031045; GO:0032456; GO:0035690; GO:0042137; GO:0042220; GO:0042593; GO:0042594; GO:0043025; GO:0043195; GO:0051412; GO:0051589; GO:0070083; GO:0071242; GO:0098700; GO:1903427 0 0 cd06174; PF07690; Q06805 CHOYP_MEGF6.33.59 m.41993 sp TIE1_BOVIN 32.836 134 66 10 15 131 210 336 1.18E-10 63.5 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q07352 CHOYP_TISDB.1.2 m.49847 sp TISB_HUMAN 61.062 113 42 2 1 111 91 203 1.18E-37 139 TISB_HUMAN reviewed "Zinc finger protein 36, C3H1 type-like 1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (Protein TIS11B)" ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B Homo sapiens (Human) 338 "3'-UTR-mediated mRNA destabilization [GO:0061158]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to raffinose [GO:0097403]; cellular response to salt stress [GO:0071472]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chorio-allantoic fusion [GO:0060710]; ERK1 and ERK2 cascade [GO:0070371]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mesendoderm development [GO:0048382]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; negative regulation of erythrocyte differentiation [GO:0045647]; neural tube development [GO:0021915]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; p38MAPK cascade [GO:0038066]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; proepicardium development [GO:0003342]; protein kinase B signaling [GO:0043491]; regulation of gene expression [GO:0010468]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of mRNA stability [GO:0043488]; regulation of myoblast differentiation [GO:0045661]; regulation of stem cell proliferation [GO:0072091]; response to wounding [GO:0009611]; spongiotrophoblast layer development [GO:0060712]; T cell differentiation in thymus [GO:0033077]; vasculogenesis [GO:0001570]" GO:0000165; GO:0000288; GO:0000932; GO:0001570; GO:0003342; GO:0003677; GO:0003700; GO:0003729; GO:0003730; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007507; GO:0008283; GO:0009611; GO:0010468; GO:0010837; GO:0014065; GO:0021915; GO:0030529; GO:0031086; GO:0031440; GO:0032869; GO:0033077; GO:0035264; GO:0035925; GO:0038066; GO:0043488; GO:0043491; GO:0044344; GO:0044822; GO:0045600; GO:0045616; GO:0045647; GO:0045657; GO:0045661; GO:0046872; GO:0048382; GO:0051028; GO:0060710; GO:0060712; GO:0061158; GO:0070371; GO:0071320; GO:0071356; GO:0071364; GO:0071375; GO:0071385; GO:0071456; GO:0071472; GO:0071560; GO:0071889; GO:0072091; GO:0097403; GO:1900153; GO:1902172; GO:1904582; GO:1904628 0 0 0 PF04553;PF00642; Q09510 CHOYP_ML12B.1.1 m.27220 sp MLRH_CAEEL 65.698 172 56 2 1 170 1 171 1.18E-77 232 MLRH_CAEEL reviewed Myosin regulatory light chain (Non-muscle myosin regulatory light chain) (nmRLC) mlc-4 C56G7.1 Caenorhabditis elegans 172 asymmetric protein localization [GO:0008105]; embryonic body morphogenesis [GO:0010172]; establishment of cell polarity [GO:0030010]; meiosis I cytokinesis [GO:0007110]; mitotic cytokinesis [GO:0000281]; nematode larval development [GO:0002119] GO:0000281; GO:0002119; GO:0005509; GO:0005737; GO:0007110; GO:0008105; GO:0010172; GO:0016459; GO:0030010 0 0 0 PF13405;PF13833; Q0VA40 CHOYP_DPER_GL16372.1.1 m.29929 sp SP9_XENTR 44.928 414 194 10 1 398 1 396 1.18E-98 303 SP9_XENTR reviewed Transcription factor Sp9 sp9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 422 "embryonic limb morphogenesis [GO:0030326]; embryonic pectoral fin morphogenesis [GO:0035118]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0030326; GO:0035118; GO:0045743; GO:0046872 0 0 0 PF00096; Q10836 CHOYP_LOC100202828.1.1 m.42969 sp TRHDE_RAT 29.856 278 165 8 12 266 522 792 1.18E-36 143 TRHDE_RAT reviewed Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase) Trhde Rattus norvegicus (Rat) 1025 cell-cell signaling [GO:0007267]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; signal transduction [GO:0007165] GO:0004177; GO:0005737; GO:0005886; GO:0006508; GO:0007165; GO:0007267; GO:0008217; GO:0008270; GO:0016021; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; Q13257 CHOYP_MAD2L1.1.1 m.10353 sp MD2L1_HUMAN 70.833 192 56 0 13 204 9 200 1.18E-99 290 MD2L1_HUMAN reviewed Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1) MAD2L1 MAD2 Homo sapiens (Human) 205 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic cell cycle checkpoint [GO:0007093]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sister chromatid cohesion [GO:0007062] GO:0000070; GO:0000776; GO:0000777; GO:0000922; GO:0005634; GO:0005829; GO:0007062; GO:0007093; GO:0007094; GO:0031145; GO:0042177; GO:0042787; GO:0042802; GO:0042803; GO:0043066; GO:0043161; GO:0045930; GO:0048471; GO:0051301; GO:0051436; GO:0051437; GO:0072686; GO:0090267; GO:1904667 0 0 0 PF02301; Q1LZH1 CHOYP_MARC2.1.1 m.50107 sp MARC2_BOVIN 38.567 293 166 5 50 337 53 336 1.18E-67 218 MARC2_BOVIN reviewed Mitochondrial amidoxime reducing component 2 (mARC2) (EC 1.-.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 2) (MOSC domain-containing protein 2) (Moco sulfurase C-terminal domain-containing protein 2) MARC2 MOSC2 Bos taurus (Bovine) 336 0 GO:0005741; GO:0005777; GO:0016491; GO:0030151; GO:0030170 0 0 0 PF03473;PF03476; Q24K15 CHOYP_LOC100641854.2.2 m.64118 sp ANGP4_BOVIN 40.351 228 126 7 80 304 275 495 1.18E-55 190 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q26619 CHOYP_BRAFLDRAFT_208819.1.1 m.61941 sp KAPR_STRPU 60.63 381 134 6 1 378 1 368 1.18E-157 451 KAPR_STRPU reviewed cAMP-dependent protein kinase type II regulatory subunit 0 Strongylocentrotus purpuratus (Purple sea urchin) 369 0 GO:0005952; GO:0008603; GO:0030552 0 0 0 PF00027;PF02197; Q28983 CHOYP_PB000445.03.0.2.2 m.34666 sp ZAN_PIG 29.741 232 157 1 36 261 302 533 1.18E-10 66.2 ZAN_PIG reviewed Zonadhesin ZAN Sus scrofa (Pig) 2476 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840 0 0 cd06263; PF08742;PF00008;PF00629;PF01826;PF12714;PF00094; Q32N22 CHOYP_TRIADDRAFT_60787.1.1 m.6621 sp TAF1B_XENLA 26.047 430 216 20 41 430 26 393 1.18E-15 84.3 TAF1B_XENLA reviewed TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) taf1b Xenopus laevis (African clawed frog) 582 RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript [GO:0001189] GO:0001164; GO:0001187; GO:0001189; GO:0046872; GO:0070860 0 0 0 PF11781; Q3MHR7 CHOYP_ARPC2.1.1 m.50573 sp ARPC2_BOVIN 71.069 318 74 1 1 318 1 300 1.18E-170 478 ARPC2_BOVIN reviewed Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) ARPC2 Bos taurus (Bovine) 300 Arp2/3 complex-mediated actin nucleation [GO:0034314]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] GO:0005200; GO:0005768; GO:0005794; GO:0005829; GO:0005885; GO:0005925; GO:0010592; GO:0031252; GO:0034314; GO:0036195; GO:0043005; GO:0045202; GO:0070062; GO:1900026 0 0 0 PF04045; Q4QR06 CHOYP_LOC587162.1.1 m.44677 sp PCGF1_XENLA 56.376 149 65 0 7 155 29 177 1.18E-54 176 PCGF1_XENLA reviewed Polycomb group RING finger protein 1 pcgf1 Xenopus laevis (African clawed frog) 259 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0008270; GO:0031519 0 0 0 PF16207; Q4R632 CHOYP_LOC580601.1.5 m.20432 sp CBPC2_MACFA 48.673 452 214 4 259 710 228 661 1.18E-144 457 CBPC2_MACFA reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) AGBL2 CCP2 QtsA-19251 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 840 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q502M6 CHOYP_LOC755521.3.28 m.27469 sp ANR29_DANRE 35 200 129 1 1 200 50 248 1.18E-37 135 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q56R14 CHOYP_LOC100378676.5.8 m.60007 sp TRI33_XENLA 19.003 321 216 8 57 346 172 479 1.18E-07 57.8 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5F478 CHOYP_ANR52.2.3 m.50820 sp ANR44_CHICK 28.571 245 132 6 69 312 143 345 1.18E-15 83.2 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5G268 CHOYP_DMBT1.28.34 m.54399 sp NETR_NOMLE 41.617 334 180 6 28 351 232 560 1.18E-77 258 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5R605 CHOYP_BRAFLDRAFT_278938.1.1 m.38684 sp CHM1A_PONAB 62.755 196 73 0 1 196 1 196 1.18E-86 256 CHM1A_PONAB reviewed Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) CHMP1A PCOLN3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 196 "cell separation after cytokinesis [GO:0000920]; gene silencing [GO:0016458]; mitotic chromosome condensation [GO:0007076]; mitotic metaphase plate congression [GO:0007080]; negative regulation of transcription by glucose [GO:0045014]; nucleus organization [GO:0006997]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; transcription, DNA-templated [GO:0006351]; vacuolar transport [GO:0007034]; vesicle-mediated transport [GO:0016192]" GO:0000794; GO:0000815; GO:0000920; GO:0005769; GO:0005815; GO:0006351; GO:0006997; GO:0007034; GO:0007076; GO:0007080; GO:0010824; GO:0015031; GO:0016192; GO:0016363; GO:0016458; GO:0045014; GO:0070062; GO:1901673 0 0 0 PF03357; Q5S006 CHOYP_BRAFLDRAFT_119973.3.3 m.52777 sp LRRK2_MOUSE 42.163 638 332 16 1 617 1438 2059 1.18E-147 476 LRRK2_MOUSE reviewed Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) Lrrk2 Mus musculus (Mouse) 2527 "activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; cellular protein localization [GO:0034613]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron death [GO:0070997]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of calcium-mediated signaling [GO:0050848]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron death [GO:1901214]; regulation of neuron maturation [GO:0014041]; regulation of protein kinase A signaling [GO:0010738]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle recycling [GO:0036465]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]" GO:0000149; GO:0000165; GO:0000186; GO:0000187; GO:0001933; GO:0001934; GO:0001948; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004708; GO:0005096; GO:0005524; GO:0005525; GO:0005615; GO:0005622; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005901; GO:0005902; GO:0006468; GO:0006897; GO:0006914; GO:0006979; GO:0007005; GO:0007030; GO:0007040; GO:0007264; GO:0007528; GO:0008021; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010738; GO:0010955; GO:0014041; GO:0015631; GO:0016234; GO:0016242; GO:0016301; GO:0016310; GO:0017048; GO:0017075; GO:0018105; GO:0018107; GO:0019722; GO:0021772; GO:0022028; GO:0030054; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030529; GO:0030672; GO:0031398; GO:0031410; GO:0031966; GO:0032091; GO:0032092; GO:0032403; GO:0032436; GO:0032473; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034613; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0035751; GO:0036465; GO:0036479; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0044325; GO:0044753; GO:0044754; GO:0045121; GO:0045202; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0050848; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060079; GO:0060159; GO:0060161; GO:0060828; GO:0061001; GO:0070062; GO:0070997; GO:0071287; GO:0072593; GO:0090263; GO:0090394; GO:0097487; GO:0098794; GO:1901214; GO:1901215; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902902; GO:1903125; GO:1903206; GO:1903215; GO:1903351; GO:1904713; GO:1904887; GO:1990909; GO:2000172; GO:2000300 0 0 0 PF16095;PF12799;PF13855;PF00069;PF08477; Q5U3C3 CHOYP_TM164.1.1 m.8397 sp TM164_HUMAN 49.237 262 116 2 10 254 9 270 1.18E-83 257 TM164_HUMAN reviewed Transmembrane protein 164 TMEM164 Homo sapiens (Human) 297 0 GO:0016021 0 0 0 PF14808; Q61097 CHOYP_LOC100375793.1.1 m.25265 sp KSR1_MOUSE 34.708 291 172 8 25 302 553 838 1.18E-40 154 KSR1_MOUSE reviewed Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) Ksr1 Ksr Mus musculus (Mouse) 873 cAMP-mediated signaling [GO:0019933]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] GO:0004672; GO:0005078; GO:0005524; GO:0005783; GO:0005789; GO:0007265; GO:0008022; GO:0016020; GO:0019933; GO:0032587; GO:0043234; GO:0043410; GO:0046872 0 0 0 PF13543;PF07714; Q64459 CHOYP_CP3AB.3.4 m.30740 sp CP3AB_MOUSE 42.095 506 269 11 1 502 1 486 1.18E-131 394 CP3AB_MOUSE reviewed Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (Cytochrome P-450IIIAM1) (Cytochrome P-450UT) Cyp3a11 Cyp3a-11 Mus musculus (Mouse) 504 0 GO:0004497; GO:0005506; GO:0005789; GO:0016491; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q6DFB7 CHOYP_LOC592888.1.1 m.63240 sp POC5_XENLA 32.795 619 327 15 50 636 11 572 1.18E-86 284 POC5_XENLA reviewed Centrosomal protein POC5 (Protein of centriole 5) poc5 Xenopus laevis (African clawed frog) 572 cell cycle [GO:0007049] GO:0005814; GO:0007049 0 0 0 0 Q6GQA6 CHOYP_CSN8.1.1 m.14798 sp CSN8_XENLA 56.684 187 80 1 27 212 8 194 1.18E-65 204 CSN8_XENLA reviewed COP9 signalosome complex subunit 8 (Signalosome subunit 8) csn8 Xenopus laevis (African clawed frog) 195 COP9 signalosome assembly [GO:0010387]; cullin deneddylation [GO:0010388] GO:0005737; GO:0008180; GO:0010387; GO:0010388 0 0 0 PF10075; Q6NS45 CHOYP_BRAFLDRAFT_121183.3.8 m.23463 sp CCD66_MOUSE 39.695 131 79 0 583 713 438 568 1.18E-12 76.3 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q6NYV9 CHOYP_LEO1.1.1 m.41626 sp LEO1_DANRE 53.292 486 180 14 144 606 154 615 1.18E-130 403 LEO1_DANRE reviewed RNA polymerase-associated protein LEO1 leo1 zgc:77374 Danio rerio (Zebrafish) (Brachydanio rerio) 696 embryonic cranial skeleton morphogenesis [GO:0048701]; glial cell development [GO:0021782]; heart development [GO:0007507]; histone modification [GO:0016570]; melanocyte differentiation [GO:0030318]; neural crest cell development [GO:0014032]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; spinal cord oligodendrocyte cell differentiation [GO:0021529]; transcription elongation from RNA polymerase II promoter [GO:0006368]; xanthophore differentiation [GO:0050936] GO:0005634; GO:0006368; GO:0007507; GO:0014032; GO:0016570; GO:0016593; GO:0021529; GO:0021782; GO:0030318; GO:0032968; GO:0045944; GO:0048701; GO:0050936; GO:1990269 0 0 0 PF04004; Q7M3Y3 CHOYP_TNNI.1.3 m.17895 sp TNNI_CHLNI 68.067 119 34 2 231 345 159 277 1.18E-38 142 TNNI_CHLNI reviewed Troponin I (TnI) 0 Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) 292 0 GO:0005861; GO:0046872 0 0 0 PF00992; Q7SXV2 CHOYP_LOC101173755.2.2 m.52937 sp AEBP2_DANRE 38.961 231 137 2 136 362 181 411 1.18E-47 169 AEBP2_DANRE reviewed Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2 homolog) (AE-binding protein 2 homolog) aebp2 si:dkey-158p11.2 zgc:63755 Danio rerio (Zebrafish) (Brachydanio rerio) 415 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0006351; GO:0006355; GO:0016569; GO:0035098; GO:0046872 0 0 0 0 Q7TMK9 CHOYP_ACSS3.1.1 m.64145 sp HNRPQ_MOUSE 56.731 416 176 4 22 434 24 438 1.18E-166 489 HNRPQ_MOUSE reviewed "Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) (pp68)" Syncrip Hnrpq Nsap1 Nsap1l Mus musculus (Mouse) 623 cellular response to interferon-gamma [GO:0071346]; circadian rhythm [GO:0007623]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA processing [GO:0006397]; negative regulation of mRNA modification [GO:0090367]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of translation [GO:0045727]; RNA splicing [GO:0008380] GO:0000166; GO:0001649; GO:0003730; GO:0005654; GO:0005737; GO:0005783; GO:0006397; GO:0007623; GO:0008143; GO:0008380; GO:0016020; GO:0017148; GO:0030529; GO:0043025; GO:0044822; GO:0045727; GO:0048027; GO:0070934; GO:0070937; GO:0071013; GO:0071204; GO:0071346; GO:0090367; GO:0097452; GO:1990635 0 0 0 PF00076; Q7ZV00 CHOYP_OTUD6B.1.2 m.20837 sp OTU6B_DANRE 25.877 228 131 10 454 678 99 291 1.18E-09 64.3 OTU6B_DANRE reviewed OTU domain-containing protein 6B (EC 3.4.19.12) otud6b zgc:56305 Danio rerio (Zebrafish) (Brachydanio rerio) 293 0 GO:0036459 0 0 0 PF02338; Q80T91 CHOYP_LOC100707338.4.5 m.42254 sp MEG11_MOUSE 37.603 242 125 11 196 425 424 651 1.18E-29 127 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8BH95 CHOYP_ECHM.1.1 m.38462 sp ECHM_MOUSE 68.561 264 83 0 37 300 26 289 1.18E-132 380 ECHM_MOUSE reviewed "Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase) (SCEH)" Echs1 Mus musculus (Mouse) 290 fatty acid beta-oxidation [GO:0006635] GO:0004300; GO:0005739; GO:0005759; GO:0006635; GO:0070062 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P30084}. 0 0 PF00378; Q8BPT6 CHOYP_ISCW_ISCW000473.1.1 m.8797 sp IMP2L_MOUSE 42.771 166 74 4 12 175 16 162 1.18E-35 125 IMP2L_MOUSE reviewed Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein) Immp2l Mus musculus (Mouse) 175 blood circulation [GO:0008015]; brain development [GO:0007420]; cellular response to DNA damage stimulus [GO:0006974]; cerebellum vasculature development [GO:0061300]; mitochondrial respiratory chain complex assembly [GO:0033108]; ovarian follicle development [GO:0001541]; ovulation [GO:0030728]; protein localization [GO:0008104]; protein processing involved in protein targeting to mitochondrion [GO:0006627]; respiratory electron transport chain [GO:0022904]; signal peptide processing [GO:0006465]; spermatogenesis [GO:0007283]; superoxide metabolic process [GO:0006801] GO:0001541; GO:0004252; GO:0005739; GO:0005743; GO:0006465; GO:0006627; GO:0006801; GO:0006974; GO:0007283; GO:0007420; GO:0008015; GO:0008104; GO:0008233; GO:0016021; GO:0022904; GO:0030728; GO:0033108; GO:0042720; GO:0061300 0 0 0 PF00717; Q8BRX9 CHOYP_LOC100552702.1.1 m.45162 sp MARH3_MOUSE 29.577 142 81 5 52 189 34 160 1.18E-07 54.7 MARH3_MOUSE reviewed E3 ubiquitin-protein ligase MARCH3 (EC 6.3.2.-) (Membrane-associated RING finger protein 3) (Membrane-associated RING-CH protein III) (MARCH-III) 3-Mar Mus musculus (Mouse) 218 endocytosis [GO:0006897]; protein ubiquitination [GO:0016567] GO:0005764; GO:0005768; GO:0006897; GO:0008270; GO:0016021; GO:0016567; GO:0016874; GO:0030659; GO:0031901 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q8BVV7 CHOYP_CEP95.1.1 m.18777 sp CEP95_MOUSE 40 85 47 3 41 123 22 104 1.18E-06 54.3 CEP95_MOUSE reviewed Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) Cep95 Ccdc45 Mus musculus (Mouse) 827 0 GO:0000922; GO:0005737; GO:0005813 0 0 0 0 Q8BYK4 CHOYP_TRIADDRAFT_37121.1.1 m.51940 sp RDH12_MOUSE 50.658 304 149 1 18 321 12 314 1.18E-101 304 RDH12_MOUSE reviewed Retinol dehydrogenase 12 (EC 1.1.1.-) Rdh12 Mus musculus (Mouse) 316 response to stimulus [GO:0050896]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601] GO:0004745; GO:0005622; GO:0007601; GO:0042572; GO:0050896 0 0 0 PF00106; Q8CFR0 CHOYP_LOC100561667.2.4 m.23366 sp C1QL2_MOUSE 34.783 138 75 6 55 187 153 280 1.18E-09 59.3 C1QL2_MOUSE reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10) C1ql2 C1qtnf10 Ctrp10 Mus musculus (Mouse) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0042802; GO:0051259 0 0 0 PF00386; Q8NDT2 CHOYP_LOC663518.1.1 m.11968 sp RB15B_HUMAN 38.624 567 253 14 243 717 327 890 1.18E-108 353 RB15B_HUMAN reviewed Putative RNA-binding protein 15B (One-twenty two protein 3) (HuOTT3) (RNA-binding motif protein 15B) RBM15B OTT3 Homo sapiens (Human) 890 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0000166; GO:0000381; GO:0003676; GO:0003723; GO:0005654; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0016032; GO:0044822 0 0 0 PF00076;PF07744; Q8NFW1 CHOYP_CO6A6.1.3 m.19274 sp COMA1_HUMAN 44.67 197 98 7 168 359 29 219 1.18E-35 143 COMA1_HUMAN reviewed Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) 1626 0 GO:0005576; GO:0005578; GO:0005581; GO:0005788 0 0 0 PF01391;PF00092; Q8R455 CHOYP_TRPM8.3.5 m.54648 sp TRPM8_RAT 25.229 547 328 16 497 995 549 1062 1.18E-37 157 TRPM8_RAT reviewed Transient receptor potential cation channel subfamily M member 8 (Cold menthol receptor 1) Trpm8 Cmr1 Rattus norvegicus (Rat) 1104 cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955] GO:0005216; GO:0005262; GO:0006874; GO:0009409; GO:0009897; GO:0016021; GO:0016048; GO:0045121; GO:0050955; GO:0051289; GO:0070207 0 0 0 0 Q8WML3 CHOYP_LOC100375795.1.1 m.25270 sp KAT6B_MACFA 30.267 337 196 8 39 356 2 318 1.18E-35 145 KAT6B_MACFA reviewed "Histone acetyltransferase KAT6B (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4)" KAT6B MYST4 QflA-12408 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 1784 "histone acetylation [GO:0016573]; histone H3 acetylation [GO:0043966]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000786; GO:0003677; GO:0004402; GO:0006334; GO:0006351; GO:0008134; GO:0008270; GO:0016407; GO:0016573; GO:0043966; GO:0045892; GO:0045893; GO:0070776 0 0 0 PF00538;PF01853;PF00628; Q99NH0 CHOYP_LOC762964.3.10 m.23561 sp ANR17_MOUSE 39.175 388 217 13 2 378 341 720 1.18E-53 194 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q99P47 CHOYP_NEMVEDRAFT_V1G170780.1.1 m.38942 sp CNTP4_MOUSE 36.975 119 70 1 4 122 69 182 1.18E-19 86.7 CNTP4_MOUSE reviewed Contactin-associated protein-like 4 (Cell recognition molecule Caspr4) Cntnap4 Caspr4 Mus musculus (Mouse) 1310 "cell adhesion [GO:0007155]; regulation of grooming behavior [GO:2000821]; regulation of synaptic transmission, dopaminergic [GO:0032225]; regulation of synaptic transmission, GABAergic [GO:0032228]" GO:0007155; GO:0016021; GO:0030054; GO:0030425; GO:0032225; GO:0032228; GO:0042734; GO:2000821 0 0 0 PF00754;PF02210; Q9C0H6 CHOYP_KLHL4.1.1 m.29567 sp KLHL4_HUMAN 59.459 74 30 0 70 143 145 218 1.18E-21 92.8 KLHL4_HUMAN reviewed Kelch-like protein 4 KLHL4 KIAA1687 Homo sapiens (Human) 718 protein ubiquitination [GO:0016567] GO:0005737; GO:0005856; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q9CWG1 CHOYP_LOC100560334.2.3 m.42997 sp GLIP1_MOUSE 43.03 165 82 5 59 218 38 195 1.18E-37 134 GLIP1_MOUSE reviewed Glioma pathogenesis-related protein 1 (GliPR 1) Glipr1 Mus musculus (Mouse) 255 0 GO:0005576; GO:0016020; GO:0016021 0 0 0 PF00188; Q9D5L7 CHOYP_LOC100377075.1.2 m.10794 sp SPSB1_MOUSE 73.455 275 71 1 3 277 1 273 1.18E-150 424 SPSB1_MOUSE reviewed SPRY domain-containing SOCS box protein 1 (SSB-1) Spsb1 Ssb1 Mus musculus (Mouse) 273 intracellular signal transduction [GO:0035556] GO:0004842; GO:0005737; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07525;PF00622; Q9D818 CHOYP_LOC100123189.1.1 m.52197 sp SAPC2_MOUSE 34.426 183 112 4 305 479 209 391 1.18E-25 111 SAPC2_MOUSE reviewed Suppressor APC domain-containing protein 2 (Protein Ang) Sapcd2 Mus musculus (Mouse) 391 0 GO:0005634; GO:0005730; GO:0005737 0 0 0 0 Q9FUN0 CHOYP_MMUM.1.1 m.45882 sp HMT1_MAIZE 40.816 98 50 3 19 116 16 105 1.18E-16 79.7 HMT1_MAIZE reviewed Homocysteine S-methyltransferase 1 (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase 1) (SMM:Hcy S-methyltransferase 1) (ZmHMT-1) HMT-1 Zea mays (Maize) 323 methionine biosynthetic process [GO:0009086] GO:0008898; GO:0009086; GO:0046872 0 0 0 PF02574; Q9H7Z3 CHOYP_LOC100018379.1.1 m.31715 sp NRDE2_HUMAN 30.179 1173 694 30 1 1080 12 1152 1.18E-128 424 NRDE2_HUMAN reviewed Protein NRDE2 homolog NRDE2 C14orf102 Homo sapiens (Human) 1164 chromatin silencing by small RNA [GO:0031048]; RNA interference [GO:0016246] GO:0016246; GO:0031048; GO:0071013 0 0 0 PF08424; Q9NZJ6 CHOYP_LOC101068003.1.1 m.14900 sp COQ3_HUMAN 48.45 258 127 2 32 285 88 343 1.18E-86 266 COQ3_HUMAN reviewed "Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114)" COQ3 UG0215E05 Homo sapiens (Human) 369 glycerol metabolic process [GO:0006071]; ubiquinone biosynthetic process [GO:0006744] GO:0004395; GO:0005739; GO:0005743; GO:0005759; GO:0006071; GO:0006744; GO:0008171; GO:0008425; GO:0008689; GO:0008757; GO:0044595; GO:0044596 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03190}. 0 0 0 Q9NZM5 CHOYP_ISCW_ISCW008669.1.1 m.20227 sp GSCR2_HUMAN 32.093 430 235 13 22 413 47 457 1.18E-37 148 GSCR2_HUMAN reviewed Glioma tumor suppressor candidate region gene 2 protein (p60) GLTSCR2 Homo sapiens (Human) 478 0 GO:0005622; GO:0005730; GO:0043231; GO:0044822 0 0 0 PF07767; Q9P2E3 CHOYP_LOC100373100.4.4 m.65650 sp ZNFX1_HUMAN 40.485 825 390 16 1250 2053 823 1567 1.18E-179 601 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9R1R2 CHOYP_TRIM3.5.58 m.4059 sp TRIM3_MOUSE 29.362 235 132 9 67 283 525 743 1.18E-17 86.3 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UIK5 CHOYP_LOC100700654.1.1 m.29871 sp TEFF2_HUMAN 29.605 152 85 6 36 171 90 235 1.18E-07 53.9 TEFF2_HUMAN reviewed Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains) TMEFF2 HPP1 TENB2 TPEF UNQ178/PRO204 Homo sapiens (Human) 374 "negative regulation of cell migration [GO:0030336]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of stress fiber assembly [GO:0051497]; wound healing, spreading of cells [GO:0044319]" GO:0005576; GO:0016021; GO:0030336; GO:0044319; GO:0045720; GO:0051497 0 0 0 PF07648; Q9WTR6 CHOYP_LOC100907715.1.1 m.66947 sp XCT_MOUSE 49.451 91 37 2 47 136 13 95 1.18E-19 87 XCT_MOUSE reviewed Cystine/glutamate transporter (Amino acid transport system xc-) (Solute carrier family 7 member 11) (xCT) Slc7a11 Mus musculus (Mouse) 502 brain development [GO:0007420]; lens fiber cell differentiation [GO:0070306]; L-glutamate transmembrane transport [GO:0089711]; platelet aggregation [GO:0070527]; response to nicotine [GO:0035094]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636] GO:0005791; GO:0005856; GO:0005887; GO:0006979; GO:0007420; GO:0009636; GO:0009986; GO:0015327; GO:0035094; GO:0070306; GO:0070527; GO:0089711 0 0 0 PF13520; Q9XTA2 CHOYP_BRAFLDRAFT_204923.2.2 m.63877 sp PPCE_BOVIN 59.551 178 71 1 1 177 217 394 1.18E-71 232 PPCE_BOVIN reviewed Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP Bos taurus (Bovine) 710 proteolysis [GO:0006508] GO:0004252; GO:0005737; GO:0006508; GO:0070008 0 0 0 PF00326;PF02897; A6QPC8 CHOYP_LOC100565039.1.2 m.596 sp EID3_BOVIN 35.045 331 195 8 34 348 49 375 1.19E-50 176 EID3_BOVIN reviewed EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) EID3 Bos taurus (Bovine) 379 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005737; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0030915 0 0 0 PF15412;PF08743; A8KBY2 CHOYP_BRF2.1.1 m.39587 sp BRF2_DANRE 26.836 354 188 13 1 312 1 325 1.19E-26 115 BRF2_DANRE reviewed Transcription factor IIIB 50 kDa subunit (B-related factor 2) (BRF-2) brf2 zgc:100856 Danio rerio (Zebrafish) (Brachydanio rerio) 423 "DNA-templated transcription, initiation [GO:0006352]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006352; GO:0006355; GO:0008270 0 0 0 PF08271; A9JTG5 CHOYP_HOIL1.3.3 m.63140 sp HOIL1_DANRE 32.416 327 184 12 15 337 183 476 1.19E-31 130 HOIL1_DANRE reviewed RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 6.3.2.-) (Heme-oxidized IRP2 ubiquitin ligase 1 homolog) (HOIL-1) rbck1 zgc:175152 Danio rerio (Zebrafish) (Brachydanio rerio) 714 embryonic cranial skeleton morphogenesis [GO:0048701]; otic vesicle morphogenesis [GO:0071600]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039] GO:0004842; GO:0008270; GO:0016874; GO:0043123; GO:0043130; GO:0043161; GO:0048701; GO:0071600; GO:0071797; GO:0097039 0 0 0 PF01485;PF16764;PF00641; B3EWZ6 CHOYP_LOC100207753.1.3 m.4699 sp MLRP2_ACRMI 29.363 361 214 13 34 373 1050 1390 1.19E-22 108 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; C3Z724 CHOYP_LOC100373734.1.1 m.25160 sp UBE2S_BRAFL 70.892 213 57 1 52 259 1 213 1.19E-101 297 UBE2S_BRAFL reviewed Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (Ubiquitin carrier protein S) (Ubiquitin-protein ligase S) BRAFLDRAFT_259979 Branchiostoma floridae (Florida lancelet) (Amphioxus) 213 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0005524; GO:0005634; GO:0005680; GO:0005737; GO:0006511; GO:0010458; GO:0010994; GO:0031145; GO:0031625; GO:0051301; GO:0061630; GO:0070979; GO:1904668 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; D2GXS7 CHOYP_BRAFLDRAFT_248419.1.2 m.4537 sp TRIM2_AILME 32.215 149 85 5 339 479 579 719 1.19E-08 61.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YXK2 CHOYP_SAFB2.1.3 m.11137 sp SAFB1_MOUSE 47.619 42 22 0 1 42 460 501 1.19E-07 55.1 SAFB1_MOUSE reviewed Scaffold attachment factor B1 (SAF-B1) Safb Safb1 Mus musculus (Mouse) 937 "growth [GO:0040007]; hormone metabolic process [GO:0042445]; intracellular estrogen receptor signaling pathway [GO:0030520]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of mRNA processing [GO:0050684]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0001047; GO:0003682; GO:0005654; GO:0006351; GO:0030520; GO:0040007; GO:0042445; GO:0043565; GO:0044822; GO:0045944; GO:0050684 0 0 0 PF00076;PF02037; H2A0M3 CHOYP_AMO.4.5 m.66262 sp AMO_PINMG 46.875 288 152 1 1 287 209 496 1.19E-87 280 AMO_PINMG reviewed Putative amine oxidase [copper-containing] (EC 1.4.3.-) 0 Pinctada margaritifera (Black-lipped pearl oyster) 781 amine metabolic process [GO:0009308] GO:0005507; GO:0005576; GO:0008131; GO:0009308; GO:0048038 0 0 0 PF01179; O01761 CHOYP_LOAG_01021.2.4 m.42820 sp UNC89_CAEEL 27.143 280 170 11 89 355 4427 4685 1.19E-09 65.5 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O15403 CHOYP_LOC100745107.3.3 m.54466 sp MOT7_HUMAN 26.263 396 275 7 10 405 23 401 1.19E-32 132 MOT7_HUMAN reviewed Monocarboxylate transporter 7 (MCT 7) (Monocarboxylate transporter 6) (MCT 6) (Solute carrier family 16 member 6) SLC16A6 MCT6 MCT7 Homo sapiens (Human) 523 monocarboxylic acid transport [GO:0015718]; plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0008028; GO:0015129; GO:0015293; GO:0015718; GO:0016020; GO:0035879 0 0 cd06174; PF07690; O42387 CHOYP_RS24.3.6 m.24606 sp RS24_TAKRU 81.102 127 24 0 16 142 4 130 1.19E-72 216 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O61462 CHOYP_RL37A.6.7 m.46554 sp RL37A_CRYST 86.957 92 12 0 18 109 1 92 1.19E-53 165 RL37A_CRYST reviewed 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) 92 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046872 0 0 0 PF01780; O75095 CHOYP_CED1.14.29 m.38768 sp MEGF6_HUMAN 27.258 609 304 27 199 704 903 1475 1.19E-22 107 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75832 CHOYP_TVAG_283050.1.1 m.65542 sp PSD10_HUMAN 32.836 134 89 1 8 141 77 209 1.19E-14 77.8 PSD10_HUMAN reviewed 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 Homo sapiens (Human) 226 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteasome regulatory particle assembly [GO:0070682]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000122; GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005838; GO:0006521; GO:0006915; GO:0007253; GO:0008134; GO:0030307; GO:0031145; GO:0031398; GO:0032088; GO:0032436; GO:0033209; GO:0038061; GO:0038095; GO:0043066; GO:0043161; GO:0043409; GO:0043488; GO:0043518; GO:0045111; GO:0045737; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070682; GO:0090090; GO:0090201; GO:0090263 0 0 0 PF00023;PF12796; P04069 CHOYP_PHUM_PHUM125580.1.1 m.47466 sp CBPB_ASTAS 47.987 298 145 5 127 422 6 295 1.19E-93 287 CBPB_ASTAS reviewed Carboxypeptidase B (EC 3.4.17.2) 0 Astacus astacus (Noble crayfish) (Astacus fluviatilis) 303 0 GO:0004181; GO:0005576; GO:0008270 0 0 0 PF00246; P06125 CHOYP_LOC100376142.1.1 m.18174 sp VIT5_CAEEL 37.805 82 43 2 170 247 506 583 1.19E-06 53.5 VIT5_CAEEL reviewed Vitellogenin-5 vit-5 C04F6.1 Caenorhabditis elegans 1603 0 GO:0005319; GO:0005576; GO:0045735 0 0 0 PF09172;PF01347;PF00094; P06603 CHOYP_TBA1.7.9 m.44110 sp TBA1_DROME 98.643 221 3 0 1 221 1 221 1.19E-162 459 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P09815 CHOYP_contig_044023 m.50853 sp ICEN_PSEFL 36.424 302 165 6 10 288 452 749 1.19E-16 84 ICEN_PSEFL reviewed Ice nucleation protein inaW Pseudomonas fluorescens 1210 0 GO:0009279; GO:0050825 0 0 0 PF00818; P10039 CHOYP_LOC100176721.3.6 m.45335 sp TENA_CHICK 38.627 233 111 13 384 604 349 561 1.19E-27 122 TENA_CHICK reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) 1808 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041;PF12661; P13903 CHOYP_BRAFLDRAFT_60376.1.1 m.6322 sp TWIST_XENLA 62.602 123 32 3 86 204 47 159 1.19E-43 146 TWIST_XENLA reviewed Twist-related protein (T18) (X-twist) twist1 xtwi Xenopus laevis (African clawed frog) 166 "neural crest formation [GO:0014029]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0014029 0 0 0 PF00010; P16157 CHOYP_LOC583072.2.25 m.2702 sp ANK1_HUMAN 26.667 840 489 34 1041 1828 19 783 1.19E-41 172 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20825 CHOYP_LOC100368444.2.2 m.56186 sp POL2_DROME 35.842 279 168 4 987 1255 162 439 1.19E-45 183 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P23381 CHOYP_SYWC.2.5 m.22899 sp SYWC_HUMAN 70 80 24 0 1 80 391 470 1.19E-34 127 SYWC_HUMAN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS IFI53 WRS Homo sapiens (Human) 471 angiogenesis [GO:0001525]; negative regulation of cell proliferation [GO:0008285]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0001525; GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006412; GO:0006418; GO:0006436; GO:0008285; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P25067 CHOYP_LOC101158517.2.3 m.23735 sp CO8A2_HUMAN 30 140 80 4 37 170 571 698 1.19E-07 53.9 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; P46060 CHOYP_RAGP1.1.1 m.64037 sp RAGP1_HUMAN 49.329 596 262 7 1 567 1 585 1.19E-170 499 RAGP1_HUMAN reviewed Ran GTPase-activating protein 1 (RanGAP1) RANGAP1 KIAA1835 SD Homo sapiens (Human) 587 cellular response to vasopressin [GO:1904117]; negative regulation of protein export from nucleus [GO:0046826]; protein sumoylation [GO:0016925]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]; sister chromatid cohesion [GO:0007062] GO:0000777; GO:0000922; GO:0005096; GO:0005635; GO:0005643; GO:0005737; GO:0005829; GO:0005913; GO:0007062; GO:0007165; GO:0016925; GO:0030425; GO:0031965; GO:0043231; GO:0044614; GO:0046826; GO:0048678; GO:0072686; GO:0098641; GO:1904115; GO:1904117; GO:1990723 0 0 0 PF13516;PF07834; P49013 CHOYP_TRIADDRAFT_26618.1.3 m.21879 sp FBP3_STRPU 57.672 189 80 0 358 546 176 364 1.19E-65 228 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P49013 CHOYP_TSNAX.1.1 m.63600 sp FBP3_STRPU 56.41 78 32 1 162 239 176 251 1.19E-19 91.3 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P49715 CHOYP_LOC100204711.1.1 m.21838 sp CEBPA_HUMAN 48.837 86 44 0 190 275 257 342 1.19E-18 88.2 CEBPA_HUMAN reviewed CCAAT/enhancer-binding protein alpha (C/EBP alpha) CEBPA CEBP Homo sapiens (Human) 358 "brown fat cell differentiation [GO:0050873]; cell maturation [GO:0048469]; cellular response to lithium ion [GO:0071285]; cellular response to organic cyclic compound [GO:0071407]; cholesterol metabolic process [GO:0008203]; cytokine-mediated signaling pathway [GO:0019221]; embryonic placenta development [GO:0001892]; fat cell differentiation [GO:0045444]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; granulocyte differentiation [GO:0030851]; inner ear development [GO:0048839]; lipid homeostasis [GO:0055088]; liver development [GO:0001889]; lung development [GO:0030324]; macrophage differentiation [GO:0030225]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription from RNA polymerase III promoter [GO:0045945]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; transcription from RNA polymerase I promoter [GO:0006360]; urea cycle [GO:0000050]; viral process [GO:0016032]; white fat cell differentiation [GO:0050872]" GO:0000050; GO:0000122; GO:0000978; GO:0001013; GO:0001077; GO:0001228; GO:0001889; GO:0001892; GO:0003677; GO:0003700; GO:0003705; GO:0003713; GO:0005634; GO:0005730; GO:0006091; GO:0006351; GO:0006360; GO:0006366; GO:0007005; GO:0007219; GO:0008134; GO:0008203; GO:0008285; GO:0016032; GO:0019221; GO:0019900; GO:0030099; GO:0030225; GO:0030324; GO:0030851; GO:0032436; GO:0042593; GO:0042803; GO:0044212; GO:0045444; GO:0045600; GO:0045669; GO:0045736; GO:0045892; GO:0045944; GO:0045945; GO:0048469; GO:0048839; GO:0050872; GO:0050873; GO:0055088; GO:0071285; GO:0071407; GO:0090575 0 0 0 PF07716; P51871 CHOYP_LOC100366418.1.1 m.36187 sp CP4F6_RAT 35.743 249 149 5 11 252 61 305 1.19E-44 160 CP4F6_RAT reviewed Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6) Cyp4f6 Rattus norvegicus (Rat) 537 inflammatory response [GO:0006954]; leukotriene metabolic process [GO:0006691] GO:0005506; GO:0005789; GO:0006691; GO:0006954; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P53563 CHOYP_contig_049491 m.58771 sp B2CL1_RAT 31.193 109 70 3 111 215 86 193 1.19E-06 51.2 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; P67985 CHOYP_RL22.2.4 m.15743 sp RL22_PIG 54 150 25 2 28 176 9 115 1.19E-35 124 RL22_PIG reviewed 60S ribosomal protein L22 (Heparin-binding protein HBp15) RPL22 Sus scrofa (Pig) 128 alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181] GO:0002181; GO:0003723; GO:0003735; GO:0008201; GO:0022625; GO:0046632 0 0 0 PF01776; Q09415 CHOYP_MYCGRDRAFT_89575.12.12 m.63173 sp SET14_CAEEL 40.625 64 34 1 94 157 32 91 1.19E-06 54.3 SET14_CAEEL reviewed SET domain-containing protein 14 set-14 R06F6.4 Caenorhabditis elegans 429 0 GO:0003677; GO:0005634; GO:0046872 0 0 0 PF01753; Q09575 CHOYP_LOC100214017.1.1 m.18531 sp YRD6_CAEEL 29.5 200 137 4 4 200 808 1006 1.19E-14 80.1 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q12955 CHOYP_AAEL_AAEL014742.3.8 m.39664 sp ANK3_HUMAN 34.694 294 188 1 1 294 64 353 1.19E-52 188 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q14162 CHOYP_LOC100908128.1.3 m.33433 sp SREC_HUMAN 32.597 181 87 10 193 342 210 386 1.19E-12 72.4 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q14596 CHOYP_LOC100372432.1.3 m.1114 sp NBR1_HUMAN 27.123 730 349 25 5 687 5 598 1.19E-49 194 NBR1_HUMAN reviewed Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 1A13B KIAA0049 M17S2 MIG19 Homo sapiens (Human) 966 macroautophagy [GO:0016236]; negative regulation of osteoblast differentiation [GO:0045668]; protein oligomerization [GO:0051259]; regulation of bone mineralization [GO:0030500]; regulation of stress-activated MAPK cascade [GO:0032872] GO:0000407; GO:0005764; GO:0005770; GO:0005776; GO:0005829; GO:0008270; GO:0016020; GO:0016236; GO:0030500; GO:0031410; GO:0031430; GO:0032872; GO:0043130; GO:0045668; GO:0051019; GO:0051259; GO:0070062 0 0 cd14947; PF16158;PF00564;PF00569; Q17QJ5 CHOYP_LOC100645644.1.1 m.55634 sp TSN5_BOVIN 53.358 268 117 6 13 274 3 268 1.19E-90 272 TSN5_BOVIN reviewed Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) 268 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007166; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q24K15 CHOYP_ANGP2.2.5 m.47960 sp ANGP4_BOVIN 35.685 241 140 5 213 451 232 459 1.19E-38 149 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q27294 CHOYP_LOC580739.1.1 m.27423 sp CAZ_DROME 57.627 59 25 0 32 90 114 172 1.19E-15 73.9 CAZ_DROME reviewed RNA-binding protein cabeza (P19) (Sarcoma-associated RNA-binding fly homolog) caz SARFH CG3606 Drosophila melanogaster (Fruit fly) 399 "adult locomotory behavior [GO:0008344]; compound eye development [GO:0048749]; larval locomotory behavior [GO:0008345]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; synaptic growth at neuromuscular junction [GO:0051124]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000166; GO:0000398; GO:0003729; GO:0005634; GO:0005654; GO:0005669; GO:0006367; GO:0008270; GO:0008344; GO:0008345; GO:0045887; GO:0048749; GO:0051124; GO:0071013 0 0 0 PF00076;PF00641; Q28DR4 CHOYP_LOC100903522.2.3 m.12042 sp H4_XENTR 100 103 0 0 15 117 1 103 1.19E-67 201 H4_XENTR reviewed Histone H4 TGas006m08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 103 "DNA-templated transcription, initiation [GO:0006352]; nucleosome assembly [GO:0006334]" GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0006352 0 0 0 0 Q3T094 CHOYP_DPSE_GA30464.1.1 m.65390 sp ETHE1_BOVIN 57.377 244 104 0 62 305 10 253 1.19E-105 311 ETHE1_BOVIN reviewed "Persulfide dioxygenase ETHE1, mitochondrial (EC 1.13.11.18) (Sulfur dioxygenase ETHE1)" ETHE1 Bos taurus (Bovine) 254 glutathione metabolic process [GO:0006749]; hydrogen sulfide metabolic process [GO:0070813] GO:0005506; GO:0005654; GO:0005759; GO:0006749; GO:0050313; GO:0070813 0 0 0 PF00753; Q504N0 CHOYP_LOC100881163.1.2 m.42958 sp CBPA2_MOUSE 34.877 367 221 9 5 362 3 360 1.19E-65 216 CBPA2_MOUSE reviewed Carboxypeptidase A2 (EC 3.4.17.15) Cpa2 Mus musculus (Mouse) 417 0 GO:0004180; GO:0004181; GO:0005576; GO:0005615; GO:0008270 0 0 0 PF00246;PF02244; Q58A42 CHOYP_BRAFLDRAFT_120072.1.1 m.3964 sp DD3_DICDI 35.053 659 301 22 19 667 21 562 1.19E-99 321 DD3_DICDI reviewed Protein DD3-3 DD3-3 DDB_G0283095 Dictyostelium discoideum (Slime mold) 616 0 GO:0016021 0 0 0 0 Q5DU00 CHOYP_DCDC2.5.7 m.42212 sp DCDC2_MOUSE 29.147 422 228 15 2 405 6 374 1.19E-34 141 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q5E936 CHOYP_RAN.1.3 m.3468 sp TXD12_BOVIN 49.419 172 81 2 1 168 3 172 1.19E-48 158 TXD12_BOVIN reviewed Thioredoxin domain-containing protein 12 (EC 1.8.4.2) TXNDC12 Bos taurus (Bovine) 172 cell redox homeostasis [GO:0045454]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236] GO:0005788; GO:0015037; GO:0019153; GO:0045454; GO:1902236 0 0 0 0 Q5F3X0 CHOYP_LCLT1.1.1 m.34910 sp LCLT1_CHICK 43.22 354 198 2 1 351 1 354 1.19E-100 305 LCLT1_CHICK reviewed Lysocardiolipin acyltransferase 1 (EC 2.3.1.-) (EC 2.3.1.51) LCLAT1 LYCAT RCJMB04_5b22 Gallus gallus (Chicken) 378 CDP-diacylglycerol biosynthetic process [GO:0016024]; multicellular organism development [GO:0007275] GO:0003841; GO:0005789; GO:0007275; GO:0016021; GO:0016024 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. 0 0 PF16076;PF01553; Q5G267 CHOYP_BRAFLDRAFT_68915.6.7 m.54400 sp NETR_MACMU 40.826 436 240 7 7 430 170 599 1.19E-104 337 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5PQJ7 CHOYP_BRAFLDRAFT_127100.1.2 m.2217 sp TBCEL_RAT 28.049 492 272 12 44 530 7 421 1.19E-46 172 TBCEL_RAT reviewed Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35) Tbcel Lrrc35 Rattus norvegicus (Rat) 424 0 GO:0005737; GO:0005856 0 0 0 PF14560; Q5R941 CHOYP_LOC659512.3.4 m.26463 sp FKB14_PONAB 45.54 213 105 7 4 211 5 211 1.19E-50 166 FKB14_PONAB reviewed Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase) FKBP14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 211 protein folding [GO:0006457] GO:0003755; GO:0005509; GO:0005788; GO:0006457 0 0 0 PF13499;PF00254; Q5RFR0 CHOYP_TTPAL.1.2 m.2245 sp TTPAL_PONAB 50 178 88 1 11 187 31 208 1.19E-55 182 TTPAL_PONAB reviewed Alpha-tocopherol transfer protein-like TTPAL Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 342 0 GO:0005215; GO:0005622; GO:0016020 0 0 0 PF00650;PF03765; Q5RJ80 CHOYP_C1QL2.5.32 m.3653 sp CAPR2_DANRE 31.111 135 80 6 213 342 786 912 1.19E-07 57 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5XIH9 CHOYP_LOC576414.1.1 m.1989 sp HPDL_RAT 32.918 401 209 12 8 400 14 362 1.19E-57 196 HPDL_RAT reviewed 4-hydroxyphenylpyruvate dioxygenase-like protein (EC 1.13.-.-) (Glyoxalase domain-containing protein 1) Hpdl Gloxd1 Rattus norvegicus (Rat) 371 aromatic amino acid family metabolic process [GO:0009072] GO:0003868; GO:0009072; GO:0046872 0 0 0 0 Q5XJK1 CHOYP_PHUM_PHUM574550.1.1 m.59401 sp SCOCB_DANRE 85.714 70 10 0 47 116 7 76 1.19E-35 120 SCOCB_DANRE reviewed Short coiled-coil protein B scocb zgc:101848 Danio rerio (Zebrafish) (Brachydanio rerio) 76 positive regulation of macroautophagy [GO:0016239]; regulation of protein complex stability [GO:0061635] GO:0000139; GO:0005829; GO:0016239; GO:0061635 0 0 0 PF10224; Q61555 CHOYP_BRAFLDRAFT_147130.2.2 m.38292 sp FBN2_MOUSE 38.403 263 147 9 6 262 1292 1545 1.19E-40 152 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q640Z6 CHOYP_NUP153.1.1 m.34857 sp NU153_XENLA 41.011 178 75 6 7 168 711 874 1.19E-30 120 NU153_XENLA reviewed Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) nup153 Xenopus laevis (African clawed frog) 1605 mRNA transport [GO:0051028]; protein transport [GO:0015031] GO:0003677; GO:0005643; GO:0008270; GO:0015031; GO:0031965; GO:0051028 0 0 0 PF08604;PF00641; Q6DIB5 CHOYP_LOC100707338.5.5 m.61713 sp MEG10_MOUSE 40.845 142 79 4 218 359 532 668 1.19E-13 77 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6NRM8 CHOYP_contig_041184 m.46949 sp ZB183_XENLA 32.759 116 66 3 98 209 346 453 1.19E-09 60.8 ZB183_XENLA reviewed Zinc finger and BTB domain-containing protein 18.3 (Zinc finger protein 238.3) zbtb18.3 znf238.3 Xenopus laevis (African clawed frog) 519 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651; Q6NZ04 CHOYP_SIX1.2.2 m.56761 sp SIX1B_DANRE 90.526 190 18 0 51 240 2 191 1.19E-130 377 SIX1B_DANRE reviewed Homeobox protein six1b (Homeobox protein six1a) (Sine oculis homeobox homolog 1a) (Sine oculis homeobox homolog 1b) six1b six1 six1a Danio rerio (Zebrafish) (Brachydanio rerio) 284 "adenohypophysis development [GO:0021984]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; extraocular skeletal muscle development [GO:0002074]; inner ear development [GO:0048839]; peripheral nervous system neuron development [GO:0048935]; pharyngeal muscle development [GO:0043282]; regulation of skeletal muscle cell proliferation [GO:0014857]; skeletal muscle fiber development [GO:0048741]; striated muscle cell differentiation [GO:0051146]; transcription, DNA-templated [GO:0006351]" GO:0002074; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0008283; GO:0014857; GO:0021984; GO:0043282; GO:0043565; GO:0048741; GO:0048839; GO:0048935; GO:0051146 0 0 0 PF00046;PF16878; Q6PFY8 CHOYP_LOC100375954.5.6 m.55179 sp TRI45_MOUSE 29.851 201 126 5 8 203 129 319 1.19E-13 75.9 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6QUW1 CHOYP_LIS1.1.1 m.56213 sp RGP51_LYMST 38.889 180 108 1 3 180 272 451 1.19E-32 124 RGP51_LYMST reviewed Retrograde protein of 51 kDa RGP51 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 452 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q6R7E2 CHOYP_CAF1B.1.4 m.626 sp IAP2_OSHVF 35.149 202 93 7 9 205 2 170 1.19E-28 108 IAP2_OSHVF reviewed Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 170 0 0 0 0 0 PF00653; Q7ZXX1 CHOYP_CEAM5.4.6 m.61547 sp CADM3_XENLA 29.771 262 152 9 88 339 69 308 1.19E-15 82 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q863A6 CHOYP_DYXC1.1.1 m.28305 sp DYXC1_PANPA 51.559 417 179 6 1 395 1 416 1.19E-127 377 DYXC1_PANPA reviewed Dyslexia susceptibility 1 candidate gene 1 protein homolog DYX1C1 EKN1 Pan paniscus (Pygmy chimpanzee) (Bonobo) 420 cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; inner dynein arm assembly [GO:0036159]; neuron migration [GO:0001764]; outer dynein arm assembly [GO:0036158]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal protein catabolic process [GO:0061136] GO:0001764; GO:0003341; GO:0005634; GO:0005737; GO:0007368; GO:0030331; GO:0033146; GO:0036158; GO:0036159; GO:0061136 0 0 0 PF04969; Q8BUZ1 CHOYP_LOC100890577.1.1 m.40402 sp ABRA_MOUSE 48.507 134 67 1 13 144 242 375 1.19E-35 129 ABRA_MOUSE reviewed Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) Abra Mus musculus (Mouse) 375 "positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein import into nucleus, translocation [GO:0000060]; transcription, DNA-templated [GO:0006351]" GO:0000060; GO:0003779; GO:0005886; GO:0006351; GO:0015629; GO:0030016; GO:0030017; GO:0035025; GO:0045893; GO:0045944; GO:0051091 0 0 0 PF14705; Q8IVV2 CHOYP_LOC100150283.1.1 m.45922 sp LOXH1_HUMAN 26.819 742 392 16 192 917 20 626 1.19E-69 257 LOXH1_HUMAN reviewed Lipoxygenase homology domain-containing protein 1 LOXHD1 Homo sapiens (Human) 1947 detection of mechanical stimulus [GO:0050982]; sensory perception of sound [GO:0007605] GO:0005262; GO:0007605; GO:0016020; GO:0032420; GO:0050982 0 0 0 PF01477; Q8JHV9 CHOYP_TIAP2.8.13 m.52284 sp BIR7A_XENLA 30.752 439 225 11 25 457 34 399 1.19E-57 198 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8R4K2 CHOYP_IRAK4.1.1 m.23405 sp IRAK4_MOUSE 35.714 476 224 11 1 473 1 397 1.19E-78 257 IRAK4_MOUSE reviewed Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) Irak4 Mus musculus (Mouse) 459 cytokine-mediated signaling pathway [GO:0019221]; cytokine production [GO:0001816]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; JNK cascade [GO:0007254]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of smooth muscle cell proliferation [GO:0048661] GO:0000287; GO:0001816; GO:0002446; GO:0004672; GO:0004674; GO:0005149; GO:0005524; GO:0005615; GO:0005634; GO:0005737; GO:0007254; GO:0019221; GO:0035556; GO:0043123; GO:0045087; GO:0048661; GO:1990266 0 0 0 PF00069; Q8TDN4 CHOYP_AAEL_AAEL005863.2.2 m.37103 sp CABL1_HUMAN 42.136 337 164 7 162 496 326 633 1.19E-67 231 CABL1_HUMAN reviewed CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) CABLES1 CABLES Homo sapiens (Human) 633 cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of cell cycle [GO:0051726] GO:0005634; GO:0005829; GO:0007049; GO:0051301; GO:0051726 0 0 0 PF00134; Q8TER0 CHOYP_SRPX2.1.1 m.37317 sp SNED1_HUMAN 34.821 112 72 1 120 231 681 791 1.19E-16 86.3 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q8VI93 CHOYP_BRAFLDRAFT_66572.1.3 m.49890 sp OAS3_MOUSE 32.063 315 184 7 86 372 803 1115 1.19E-38 150 OAS3_MOUSE reviewed "2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (2',5'-oligoadenylate synthetase-like 10)" Oas3 oasl10 Mus musculus (Mouse) 1138 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615] GO:0001730; GO:0003725; GO:0005524; GO:0005615; GO:0005654; GO:0005737; GO:0005886; GO:0009615; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060700 0 0 0 PF01909;PF10421; Q8WVB3 CHOYP_HEXDC.1.1 m.34 sp HEXDC_HUMAN 43.172 454 248 6 6 454 10 458 1.19E-122 369 HEXDC_HUMAN reviewed Hexosaminidase D (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase D) (Hexosaminidase domain-containing protein) (N-acetyl-beta-galactosaminidase) HEXDC Homo sapiens (Human) 486 carbohydrate metabolic process [GO:0005975] GO:0004563; GO:0005634; GO:0005737; GO:0005975; GO:0015929 0 0 0 PF00728; Q91WN1 CHOYP_TTHERM_00919690.1.1 m.30754 sp DNJC9_MOUSE 50 70 32 2 48 115 159 227 1.19E-09 57 DNJC9_MOUSE reviewed DnaJ homolog subfamily C member 9 Dnajc9 Mus musculus (Mouse) 259 positive regulation of ATPase activity [GO:0032781]; social behavior [GO:0035176] GO:0005615; GO:0005634; GO:0005737; GO:0005886; GO:0031072; GO:0032781; GO:0035176 0 0 cd06257; PF00226; Q95NR9 CHOYP_CALM.50.50 m.67046 sp CALM_METSE 91.525 118 10 0 1 118 31 148 1.19E-75 223 CALM_METSE reviewed Calmodulin (CaM) 0 Metridium senile (Brown sea anemone) (Frilled sea anemone) 149 0 GO:0005509 0 0 0 PF13499; Q96AY4 CHOYP_LOC100374969.1.1 m.55764 sp TTC28_HUMAN 35.366 246 122 6 959 1174 1480 1718 1.19E-29 133 TTC28_HUMAN reviewed Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) 2481 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of mitotic cell cycle [GO:0007346] GO:0000922; GO:0005737; GO:0005813; GO:0007067; GO:0007346; GO:0030496; GO:0051301 0 0 0 PF12770;PF13176;PF13181; Q96RW7 CHOYP_LOC100366398.1.1 m.23184 sp HMCN1_HUMAN 23.821 403 260 17 6 396 4019 4386 1.19E-07 59.7 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BUN8 CHOYP_LOC100375321.1.1 m.62246 sp DERL1_HUMAN 62.097 248 94 0 4 251 2 249 1.19E-113 329 DERL1_HUMAN reviewed Derlin-1 (Degradation in endoplasmic reticulum protein 1) (DERtrin-1) (Der1-like protein 1) DERL1 DER1 UNQ243/PRO276 Homo sapiens (Human) 251 "endoplasmic reticulum unfolded protein response [GO:0030968]; ERAD pathway [GO:0036503]; ER-associated misfolded protein catabolic process [GO:0071712]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; establishment of protein localization [GO:0045184]; intracellular transport of viral protein in host cell [GO:0019060]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; protein destabilization [GO:0031648]; protein homooligomerization [GO:0051260]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]" GO:0002020; GO:0004872; GO:0005769; GO:0005770; GO:0005783; GO:0006986; GO:0016020; GO:0016021; GO:0019060; GO:0030176; GO:0030433; GO:0030968; GO:0030970; GO:0031398; GO:0031625; GO:0031648; GO:0032092; GO:0036502; GO:0036503; GO:0036513; GO:0042288; GO:0043657; GO:0045184; GO:0051117; GO:0051260; GO:0071712; GO:1990381 0 0 0 0 Q9BW85 CHOYP_NEMVEDRAFT_V1G237797.1.1 m.40688 sp CCD94_HUMAN 44.652 374 153 5 1 374 1 320 1.19E-89 275 CCD94_HUMAN reviewed Coiled-coil domain-containing protein 94 CCDC94 Homo sapiens (Human) 323 0 0 0 0 0 PF04502; Q9C040 CHOYP_BRAFLDRAFT_206799.4.23 m.13202 sp TRIM2_HUMAN 33.333 78 51 1 7 84 667 743 1.19E-06 49.3 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9DE09 CHOYP_HMX1.1.1 m.28407 sp HMX1_CHICK 49.573 117 29 2 105 191 201 317 1.19E-27 109 HMX1_CHICK reviewed Homeobox protein HMX1 (GH6) (Homeobox protein H6) HMX1 H6 Gallus gallus (Chicken) 333 "multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0001227; GO:0003677; GO:0005634; GO:0006351; GO:0007275; GO:0045892 0 0 0 PF00046; Q9EPQ1 CHOYP_TLR22.1.3 m.42834 sp TLR1_MOUSE 23.765 749 437 37 59 736 90 775 1.19E-24 113 TLR1_MOUSE reviewed Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Tlr1 Mus musculus (Mouse) 795 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; detection of triacyl bacterial lipopeptide [GO:0042495]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 1 signaling pathway [GO:0034130]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0002755; GO:0004888; GO:0005794; GO:0005887; GO:0006952; GO:0006954; GO:0007250; GO:0016020; GO:0030670; GO:0034130; GO:0035354; GO:0035355; GO:0035663; GO:0042116; GO:0042495; GO:0042497; GO:0042535; GO:0042742; GO:0045087; GO:0045121; GO:0045335; GO:0045410; GO:0046982; GO:0050707; GO:0071723; GO:0071726; GO:0071727 0 0 0 PF12799;PF13855;PF01582; Q9ESN6 CHOYP_LOC100373444.14.79 m.20470 sp TRIM2_MOUSE 27.434 226 129 8 345 556 536 740 1.19E-13 78.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H0J9 CHOYP_NEMVEDRAFT_V1G207141.1.1 m.36945 sp PAR12_HUMAN 27.189 217 141 5 50 259 10 216 1.19E-17 85.9 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9N2W7 CHOYP_SMP_082940.1.1 m.3343 sp NDUAC_CAEEL 49.242 132 66 1 23 153 8 139 1.19E-43 144 NDUAC_CAEEL reviewed Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NADH-ubiquinone oxidoreductase 17.0 kDa subunit) Y94H6A.8 Caenorhabditis elegans 146 0 GO:0005739; GO:0005743; GO:0008137; GO:0009055; GO:0070469 0 0 0 PF05071; Q9NDM2 CHOYP_LOC100905010.1.1 m.851 sp GUTR1_DROME 28.283 297 186 5 36 307 42 336 1.19E-24 106 GUTR1_DROME reviewed Protein trapped in endoderm-1 Tre1 CG3171 Drosophila melanogaster (Fruit fly) 392 cell surface receptor signaling pathway [GO:0007166]; ectopic germ cell programmed cell death [GO:0035234]; germ cell development [GO:0007281]; germ cell migration [GO:0008354]; G-protein coupled receptor signaling pathway [GO:0007186]; pole cell migration [GO:0007280] GO:0004930; GO:0005887; GO:0005938; GO:0007166; GO:0007186; GO:0007280; GO:0007281; GO:0008354; GO:0016021; GO:0035234 0 0 0 PF00001; Q9R1R2 CHOYP_BRAFLDRAFT_87295.2.9 m.20548 sp TRIM3_MOUSE 26.667 150 103 3 174 321 599 743 1.19E-09 63.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9V4M2 CHOYP_WECH.1.1 m.23909 sp WECH_DROME 36.364 77 45 2 3 76 544 619 1.19E-06 49.7 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; Q9VCA2 CHOYP_S22AL.1.1 m.65624 sp ORCT_DROME 30.515 544 333 10 8 536 4 517 1.19E-66 229 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9W5U2 CHOYP_ISCW_ISCW016212.1.2 m.2539 sp CHIT3_DROME 37.352 846 465 22 1 799 994 1821 1.19E-164 542 CHIT3_DROME reviewed Probable chitinase 3 (EC 3.2.1.14) (Probable chitinase 1) Cht3 Cht1 CG18140 Drosophila melanogaster (Fruit fly) 2286 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0006032; GO:0008061 0 0 0 PF01607;PF00704; A0A0R4IBK5 CHOYP_LOC100377154.2.4 m.38173 sp R213A_DANRE 29.712 626 377 18 493 1087 1028 1621 1.20E-61 235 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0JM12 CHOYP_LOC579946.12.24 m.43231 sp MEG10_XENTR 41.322 121 63 5 15 135 549 661 1.20E-11 67.4 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AV25 CHOYP_LOC101067075.2.2 m.57423 sp FBCD1_MOUSE 52.778 216 92 3 54 259 238 453 1.20E-73 234 FBCD1_MOUSE reviewed Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) 459 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; A7MBP4 CHOYP_LOC590756.4.6 m.48555 sp IFT46_DANRE 50.394 381 149 8 19 399 43 383 1.20E-112 337 IFT46_DANRE reviewed Intraflagellar transport protein 46 homolog ift46 Danio rerio (Zebrafish) (Brachydanio rerio) 384 cilium assembly [GO:0042384]; determination of ventral identity [GO:0048264]; intraciliary transport [GO:0042073]; pronephros development [GO:0048793]; retina development in camera-type eye [GO:0060041] GO:0005737; GO:0005813; GO:0030992; GO:0036064; GO:0042073; GO:0042384; GO:0048264; GO:0048793; GO:0060041 0 0 0 PF12317; A7T167 CHOYP_GDAP2.1.1 m.57049 sp GDAP2_NEMVE 47.515 503 244 7 3 496 2 493 1.20E-170 493 GDAP2_NEMVE reviewed Protein GDAP2 homolog gdap2 v1g195342 Nematostella vectensis (Starlet sea anemone) 502 0 0 0 0 0 PF13716;PF01661; B0BLT0 CHOYP_LOC100876834.1.1 m.28763 sp ZN593_XENTR 55.645 124 53 1 70 191 1 124 1.20E-41 140 ZN593_XENTR reviewed Zinc finger protein 593 znf593 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 0 GO:0003676; GO:0008270 0 0 0 PF12171; B3DM66 CHOYP_LOC100893874.1.1 m.55855 sp GP161_XENTR 32.792 308 191 5 45 352 39 330 1.20E-44 165 GP161_XENTR reviewed G-protein coupled receptor 161 gpr161 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 518 G-protein coupled receptor signaling pathway [GO:0007186]; multicellular organism development [GO:0007275]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; positive regulation of cAMP biosynthetic process [GO:0030819] GO:0004930; GO:0007186; GO:0007275; GO:0016021; GO:0030819; GO:0055037; GO:0060170; GO:0072372; GO:1901621 0 0 0 PF00001; D2GXS7 CHOYP_BRAFLDRAFT_123270.1.1 m.43226 sp TRIM2_AILME 36.111 108 65 3 444 548 627 733 1.20E-10 68.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F1LQ48 CHOYP_TBK1.4.5 m.40693 sp HNRPL_RAT 47.875 447 180 10 14 432 90 511 1.20E-122 373 HNRPL_RAT reviewed Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Hnrnpl Fblim1 Rattus norvegicus (Rat) 623 "cellular response to amino acid starvation [GO:0034198]; circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to peptide [GO:1901652]" GO:0000166; GO:0000381; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006397; GO:0007623; GO:0030529; GO:0034198; GO:0035770; GO:0044212; GO:0045727; GO:0048025; GO:0048471; GO:0097157; GO:1901652; GO:1902416; GO:1990715 0 0 0 PF00076; O01761 CHOYP_UNC89.5.19 m.24934 sp UNC89_CAEEL 25.852 499 305 25 100 574 4228 4685 1.20E-14 83.2 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O43301 CHOYP_LOC770082.2.4 m.25814 sp HS12A_HUMAN 27.17 622 367 16 1031 1576 57 668 1.20E-48 189 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O60244 CHOYP_MED14.1.2 m.26275 sp MED14_HUMAN 42 100 50 4 5 100 1353 1448 1.20E-11 62.8 MED14_HUMAN reviewed Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) MED14 ARC150 CRSP2 CXorf4 DRIP150 EXLM1 RGR1 TRAP170 Homo sapiens (Human) 1454 "androgen receptor signaling pathway [GO:0030521]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; stem cell population maintenance [GO:0019827]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001104; GO:0003712; GO:0003713; GO:0004872; GO:0005634; GO:0005654; GO:0006357; GO:0006367; GO:0016020; GO:0016592; GO:0019827; GO:0030374; GO:0030518; GO:0030521; GO:0042809; GO:0045893; GO:0045944; GO:0070847 0 0 0 PF08638; O70277 CHOYP_BRAFLDRAFT_87272.6.6 m.64686 sp TRIM3_RAT 24.503 151 108 3 28 175 593 740 1.20E-07 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_102380.1.11 m.387 sp TRIM3_HUMAN 23.372 261 167 9 87 329 486 731 1.20E-11 69.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O77245 CHOYP_LOC100161053.1.1 m.6306 sp E75_METEN 41.908 346 195 4 109 449 30 374 1.20E-85 278 E75_METEN reviewed Nuclear hormone receptor E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis) 606 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; O77302 CHOYP_RS10.4.5 m.30129 sp RS10_LUMRU 76.282 156 29 2 1 153 1 151 1.20E-79 235 RS10_LUMRU reviewed 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) 156 0 GO:0005840 0 0 0 PF03501; O95433 CHOYP_LOC100368486.1.1 m.18263 sp AHSA1_HUMAN 44.058 345 186 3 1 345 1 338 1.20E-106 318 AHSA1_HUMAN reviewed Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38) AHSA1 C14orf3 HSPC322 Homo sapiens (Human) 338 response to stress [GO:0006950] GO:0001671; GO:0005737; GO:0005783; GO:0005829; GO:0005913; GO:0006950; GO:0051087; GO:0070062; GO:0098641 0 0 0 PF09229;PF08327; P06280 CHOYP_LOC663249.1.1 m.25441 sp AGAL_HUMAN 53.448 348 160 2 14 360 26 372 1.20E-136 400 AGAL_HUMAN reviewed Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Melibiase) (Agalsidase) GLA Homo sapiens (Human) 429 glycosphingolipid catabolic process [GO:0046479]; glycosphingolipid metabolic process [GO:0006687]; glycosylceramide catabolic process [GO:0046477]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of nitric-oxide synthase activity [GO:0051001]; oligosaccharide metabolic process [GO:0009311] GO:0003824; GO:0004557; GO:0005102; GO:0005576; GO:0005737; GO:0005764; GO:0005794; GO:0006687; GO:0009311; GO:0016787; GO:0016936; GO:0042803; GO:0043202; GO:0045019; GO:0046477; GO:0046479; GO:0051001; GO:0052692; GO:0070062 0 0 cd14792; PF16499; P10039 CHOYP_LOC100367879.1.3 m.3078 sp TENA_CHICK 43.662 213 115 4 230 442 1590 1797 1.20E-46 176 TENA_CHICK reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) 1808 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041;PF12661; P18101 CHOYP_LOC100695843.1.4 m.16110 sp RL40_DROME 98.824 85 1 0 14 98 1 85 1.20E-55 171 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; P22897 CHOYP_LOC576927.4.4 m.55423 sp MRC1_HUMAN 30.146 1025 619 37 818 1804 422 1387 1.20E-113 400 MRC1_HUMAN reviewed Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0001618; GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0005887; GO:0006898; GO:0009986; GO:0010008; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; P28828 CHOYP_PTPRZ.6.9 m.32393 sp PTPRM_MOUSE 31.687 587 354 13 2 556 880 1451 1.20E-84 291 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P29371 CHOYP_LOC100376472.1.1 m.22173 sp NK3R_HUMAN 29.289 239 148 6 1 237 153 372 1.20E-29 119 NK3R_HUMAN reviewed Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) TACR3 NK3R TAC3R Homo sapiens (Human) 465 aging [GO:0007568]; hyperosmotic salinity response [GO:0042538]; positive regulation of blood pressure [GO:0045777]; positive regulation of heart rate [GO:0010460]; positive regulation of uterine smooth muscle contraction [GO:0070474]; regulation of dopamine metabolic process [GO:0042053]; regulation of feeding behavior [GO:0060259]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to morphine [GO:0043278]; tachykinin receptor signaling pathway [GO:0007217] GO:0004995; GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0007217; GO:0007568; GO:0010460; GO:0032355; GO:0032590; GO:0032809; GO:0042053; GO:0042220; GO:0042538; GO:0043278; GO:0045777; GO:0060259; GO:0070474 0 0 0 PF00001; P31643 CHOYP_S6A11.1.1 m.58010 sp SC6A6_RAT 64.706 204 72 0 1 204 246 449 1.20E-82 260 SC6A6_RAT reviewed Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) Slc6a6 Rattus norvegicus (Rat) 621 amino acid transmembrane transport [GO:0003333]; taurine transport [GO:0015734] GO:0003333; GO:0005328; GO:0005369; GO:0005887; GO:0015734; GO:0030977 0 0 0 PF00209; P49897 CHOYP_IOD1.2.2 m.51211 sp IOD3_RAT 36.782 87 45 2 44 120 83 169 1.20E-08 54.7 IOD3_RAT reviewed Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase) Dio3 Itdi3 Txdi3 Rattus norvegicus (Rat) 304 brown fat cell proliferation [GO:0070342]; hormone biosynthetic process [GO:0042446]; response to hypoxia [GO:0001666]; thyroid hormone metabolic process [GO:0042403] GO:0001666; GO:0004800; GO:0005886; GO:0010008; GO:0016021; GO:0042403; GO:0042446; GO:0070342 0 0 0 PF00837; P55042 CHOYP_LOC100865163.2.5 m.36091 sp RAD_HUMAN 35.398 226 120 7 149 357 92 308 1.20E-33 129 RAD_HUMAN reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) RRAD RAD Homo sapiens (Human) 308 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; P70031 CHOYP_CCKAR.1.6 m.24599 sp CCKAR_XENLA 23.288 365 238 12 53 404 74 409 1.20E-13 75.9 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; P77735 CHOYP_LOC587705.2.2 m.11817 sp YAJO_ECOLI 40.29 345 176 10 1 339 1 321 1.20E-65 213 YAJO_ECOLI reviewed Uncharacterized oxidoreductase YajO (EC 1.-.-.-) yajO b0419 JW0409 Escherichia coli (strain K12) 324 thiamine metabolic process [GO:0006772] GO:0005829; GO:0006772; GO:0016491 0 0 cd06660; PF00248; P79345 CHOYP_NPC2.5.7 m.30911 sp NPC2_BOVIN 41.912 136 76 1 6 138 9 144 1.20E-34 120 NPC2_BOVIN reviewed Epididymal secretory protein E1 (EPV20) (Niemann Pick type C2 protein homolog) NPC2 Bos taurus (Bovine) 149 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; response to virus [GO:0009615] GO:0005764; GO:0005783; GO:0008203; GO:0009615; GO:0015485; GO:0030301; GO:0032367; GO:0033344; GO:0042632; GO:0070062 0 0 0 PF02221; P82198 CHOYP_METEV_0975.1.1 m.28991 sp BGH3_MOUSE 33.716 261 155 7 36 293 389 634 1.20E-26 113 BGH3_MOUSE reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) Tgfbi Mus musculus (Mouse) 683 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198] GO:0001525; GO:0002062; GO:0005518; GO:0005578; GO:0005604; GO:0005615; GO:0005802; GO:0007155; GO:0008283; GO:0030198; GO:0050839; GO:0050840; GO:0070062 0 0 0 PF02469; Q00808 CHOYP_BRAFLDRAFT_117940.1.1 m.59223 sp HETE1_PODAS 28.692 237 128 6 568 771 894 1122 1.20E-12 75.9 HETE1_PODAS reviewed Vegetative incompatibility protein HET-E-1 HET-E1 Podospora anserina (Pleurage anserina) 1356 0 GO:0005525 0 0 0 PF06985;PF00400; Q03142 CHOYP_FGFR2.1.3 m.20151 sp FGFR4_MOUSE 30.769 221 137 6 28 234 141 359 1.20E-24 111 FGFR4_MOUSE reviewed Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Protein-tyrosine kinase receptor MPK-11) (CD antigen CD334) Fgfr4 Fgfr-4 Mpk-11 Mus musculus (Mouse) 799 alveolar secondary septum development [GO:0061144]; cell migration [GO:0016477]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glucose homeostasis [GO:0042593]; lung development [GO:0030324]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of gene expression [GO:0010629]; organ induction [GO:0001759]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphate ion homeostasis [GO:0055062]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of parathyroid hormone secretion [GO:2000830]; positive regulation of proteolysis [GO:0045862]; protein autophosphorylation [GO:0046777]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of cholesterol homeostasis [GO:2000188]; regulation of extracellular matrix disassembly [GO:0010715]; regulation of lipid metabolic process [GO:0019216]; regulation of phosphorus metabolic process [GO:0051174]; vacuolar phosphate transport [GO:0007037]; vitamin D3 metabolic process [GO:0070640] GO:0001759; GO:0005007; GO:0005524; GO:0005654; GO:0005737; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0007037; GO:0008201; GO:0008284; GO:0008543; GO:0010628; GO:0010629; GO:0010715; GO:0016477; GO:0017134; GO:0018108; GO:0019216; GO:0030133; GO:0030324; GO:0042593; GO:0043085; GO:0045862; GO:0046777; GO:0051174; GO:0055062; GO:0061144; GO:0070374; GO:0070640; GO:0070857; GO:0090272; GO:2000188; GO:2000573; GO:2000830 0 0 0 PF07679;PF07714; Q13490 CHOYP_BIRC2.13.13 m.60036 sp BIRC2_HUMAN 32.203 354 209 6 473 800 270 618 1.20E-47 182 BIRC2_HUMAN reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 MIHB RNF48 Homo sapiens (Human) 618 "cell surface receptor signaling pathway [GO:0007166]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; NIK/NF-kappaB signaling [GO:0038061]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell proliferation [GO:0042127]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006921; GO:0007166; GO:0007249; GO:0008270; GO:0009898; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0033209; GO:0034121; GO:0035631; GO:0035666; GO:0038061; GO:0039535; GO:0042127; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045088; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0070266; GO:0070424; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000116; GO:2000377 0 0 0 PF00653;PF00619; Q25145 CHOYP_TPM2.6.8 m.38169 sp TPM_HALRU 83.251 203 34 0 48 250 82 284 1.20E-105 310 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q25490 CHOYP_LOC100377089.2.2 m.45339 sp APLP_MANSE 29.338 317 203 7 38 353 27 323 1.20E-29 124 APLP_MANSE reviewed Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 3305 Wnt signaling pathway [GO:0016055] GO:0005319; GO:0005576; GO:0008289; GO:0016055 0 0 0 PF06448;PF09172;PF01347;PF00094; Q28DS3 CHOYP_LOC100370682.1.1 m.59016 sp RN170_XENTR 51.406 249 109 4 4 247 13 254 1.20E-85 258 RN170_XENTR reviewed E3 ubiquitin-protein ligase RNF170 (EC 6.3.2.-) (RING finger protein 170) rnf170 TGas116k14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 chordate embryonic development [GO:0043009]; protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874; GO:0043009 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF06803;PF00097; Q3SX22 CHOYP_BRAFLDRAFT_88506.1.1 m.64174 sp BSDC1_BOVIN 34.641 459 245 16 10 446 36 461 1.20E-58 202 BSDC1_BOVIN reviewed BSD domain-containing protein 1 BSDC1 Bos taurus (Bovine) 461 0 0 0 0 0 PF03909; Q3SZZ0 CHOYP_BRX1.1.1 m.30421 sp BRX1_BOVIN 66.418 268 88 1 37 302 50 317 1.20E-135 391 BRX1_BOVIN reviewed Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2) BRIX1 BRIX BXDC2 Bos taurus (Bovine) 353 ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0003723; GO:0005730; GO:0044822 0 0 0 PF04427; Q502M6 CHOYP_LOC100641729.7.10 m.46684 sp ANR29_DANRE 41.758 182 105 1 129 309 6 187 1.20E-34 130 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q504N0 CHOYP_contig_028734 m.32659 sp CBPA2_MOUSE 30.392 204 128 5 5 201 3 199 1.20E-22 97.4 CBPA2_MOUSE reviewed Carboxypeptidase A2 (EC 3.4.17.15) Cpa2 Mus musculus (Mouse) 417 0 GO:0004180; GO:0004181; GO:0005576; GO:0005615; GO:0008270 0 0 0 PF00246;PF02244; Q5IS76 CHOYP_LOC100313543.2.2 m.57202 sp ACHA6_PANTR 25.893 448 305 10 37 459 42 487 1.20E-42 160 ACHA6_PANTR reviewed Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Pan troglodytes (Chimpanzee) 494 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; membrane depolarization [GO:0051899]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0014059; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0051899; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; Q5J3Q5 CHOYP_LOC100702474.1.1 m.17592 sp FOXE1_XENLA 66.337 101 30 2 99 197 56 154 1.20E-38 145 FOXE1_XENLA reviewed Forkhead box protein E1 (FoxE1) foxe1 Xenopus laevis (African clawed frog) 379 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0005634; GO:0006351; GO:0006357; GO:0043565 0 0 0 PF00250; Q5RL51 CHOYP_MED25.2.2 m.42846 sp GSTCD_MOUSE 27.422 547 282 18 2 530 7 456 1.20E-40 158 GSTCD_MOUSE reviewed Glutathione S-transferase C-terminal domain-containing protein Gstcd Mus musculus (Mouse) 634 0 GO:0005737; GO:0070062 0 0 0 PF14497;PF13679; Q5UR67 CHOYP_contig_039985 m.45231 sp RIBX_MIMIV 46.575 146 73 2 338 478 21 166 1.20E-30 120 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q69Z28 CHOYP_ATS2.1.2 m.39791 sp ATS16_MOUSE 24.479 384 241 11 309 691 276 611 1.20E-23 112 ATS16_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Adamts16 Kiaa2029 Mus musculus (Mouse) 1222 branching involved in ureteric bud morphogenesis [GO:0001658]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] GO:0001658; GO:0003073; GO:0004222; GO:0005578; GO:0008270; GO:1902017 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q69Z37 CHOYP_LOC100368821.6.7 m.49224 sp SAM9L_MOUSE 28 275 167 6 74 333 90 348 1.20E-22 103 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q69Z66 CHOYP_MYSM1.1.1 m.10132 sp MYSM1_MOUSE 49.318 440 207 6 451 876 363 800 1.20E-132 420 MYSM1_MOUSE reviewed "Histone H2A deubiquitinase MYSM1 (2A-DUB) (EC 3.4.19.-) (Myb-like, SWIRM and MPN domain-containing protein 1)" Mysm1 Kiaa1915 Mus musculus (Mouse) 819 "chromatin remodeling [GO:0006338]; monoubiquitinated histone H2A deubiquitination [GO:0035522]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of hair follicle development [GO:0051797]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003713; GO:0004843; GO:0005634; GO:0006338; GO:0006351; GO:0008237; GO:0030334; GO:0032403; GO:0035522; GO:0042393; GO:0045944; GO:0046872; GO:0051797 0 0 0 PF01398;PF00249;PF04433; Q6AY09 CHOYP_LOC101160053.1.1 m.18848 sp HNRH2_RAT 39.796 196 106 5 49 233 13 207 1.20E-36 139 HNRH2_RAT reviewed "Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed]" Hnrnph2 Hnrph2 Rattus norvegicus (Rat) 449 0 GO:0000166; GO:0005654; GO:0005737; GO:0016020; GO:0030529; GO:0044822 0 0 0 PF00076;PF08080; Q6GL75 CHOYP_DCC1.1.1 m.18063 sp DCC1_XENTR 43.921 403 211 3 16 417 3 391 1.20E-113 341 DCC1_XENTR reviewed Sister chromatid cohesion protein DCC1 dscc1 dcc1 TNeu038i11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 391 DNA replication [GO:0006260]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; regulation of DNA replication [GO:0006275] GO:0000775; GO:0000785; GO:0003677; GO:0005654; GO:0006260; GO:0006275; GO:0031390; GO:0034088 0 0 0 PF09724; Q6INS1 CHOYP_BRAFLDRAFT_115491.1.1 m.14945 sp FBXL5_XENLA 36.635 737 367 19 19 719 5 677 1.20E-127 397 FBXL5_XENLA reviewed F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) fbxl5 Xenopus laevis (African clawed frog) 678 iron ion homeostasis [GO:0055072]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005506; GO:0016567; GO:0019005; GO:0031146; GO:0048471; GO:0055072 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF01814;PF13516; Q6ITT3 CHOYP_LOC100372236.3.4 m.54964 sp MGT4C_PIG 38.66 388 229 8 143 527 97 478 1.20E-82 268 MGT4C_PIG reviewed "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Sus scrofa (Pig) 478 N-glycan processing [GO:0006491] GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04666; Q6P2X9 CHOYP_MOT12.1.2 m.13250 sp MOT12_XENTR 23.604 394 265 7 4 364 10 400 1.20E-20 97.4 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6PJF5 CHOYP_RHO-5.1.1 m.64450 sp RHDF2_HUMAN 40.289 484 260 8 223 698 389 851 1.20E-125 397 RHDF2_HUMAN reviewed Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) RHBDF2 IRHOM2 RHBDL5 RHBDL6 Homo sapiens (Human) 856 negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; proteolysis [GO:0006508]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of protein secretion [GO:0050708] GO:0005789; GO:0005886; GO:0006508; GO:0015031; GO:0016021; GO:0042058; GO:0050708; GO:0050709 0 0 0 PF01694;PF12595; Q6UXK5 CHOYP_LOC410825.1.1 m.15362 sp LRRN1_HUMAN 28.633 461 277 13 23 461 32 462 1.20E-35 148 LRRN1_HUMAN reviewed Leucine-rich repeat neuronal protein 1 (Neuronal leucine-rich repeat protein 1) (NLRR-1) LRRN1 KIAA1497 Nbla10449 UNQ693/PRO1338 Homo sapiens (Human) 716 positive regulation of synapse assembly [GO:0051965] GO:0016021; GO:0051965 0 0 0 PF07679;PF13855; Q7PCJ9 CHOYP_BRAFLDRAFT_285620.5.6 m.46904 sp SAT2_PIG 31.579 171 104 4 1 161 1 168 1.20E-22 91.3 SAT2_PIG reviewed Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) SAT2 SSAT2 Sus scrofa (Pig) 170 putrescine catabolic process [GO:0009447] GO:0004145; GO:0005737; GO:0009447 PATHWAY: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. 0 0 PF00583; Q7Z0T3 CHOYP_ACDOPBH.4.9 m.37320 sp TEMPT_APLCA 49.558 113 56 1 32 143 8 120 1.20E-29 117 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q864S8 CHOYP_BRCA2.2.2 m.48307 sp BRCA2_FELCA 33.333 366 214 13 1 354 2759 3106 1.20E-46 176 BRCA2_FELCA reviewed Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog) BRCA2 FANCD1 Felis catus (Cat) (Felis silvestris catus) 3372 "centrosome duplication [GO:0051298]; chromosome organization [GO:0051276]; cytokinesis [GO:0000910]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; nucleotide-excision repair [GO:0006289]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell proliferation [GO:0042127]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000724; GO:0000910; GO:0003697; GO:0005634; GO:0005813; GO:0006289; GO:0006302; GO:0006355; GO:0030141; GO:0033593; GO:0033600; GO:0042127; GO:0043015; GO:0043234; GO:0045893; GO:0051276; GO:0051298 0 0 0 PF09169;PF09103;PF09104;PF00634;PF09121; Q86FP7 CHOYP_RS23.9.9 m.60319 sp RS23_DERVA 83.333 144 22 2 9 151 1 143 1.20E-80 238 RS23_DERVA reviewed 40S ribosomal protein S23 RpS23 Dermacentor variabilis (American dog tick) 143 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935 0 0 cd03367; PF00164; Q8BU85 CHOYP_MSRB3.2.4 m.17278 sp MSRB3_MOUSE 58.125 160 65 2 12 170 68 226 1.20E-62 197 MSRB3_MOUSE reviewed "Methionine-R-sulfoxide reductase B3, mitochondrial (MsrB3) (EC 1.8.4.-)" Msrb3 Mus musculus (Mouse) 253 protein repair [GO:0030091]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005783; GO:0006979; GO:0008270; GO:0030091; GO:0033743 0 0 0 PF01641; Q8BXX9 CHOYP_BRAFLDRAFT_117200.2.2 m.63787 sp CC169_MOUSE 34.746 118 60 4 93 209 111 212 1.20E-11 64.7 CC169_MOUSE reviewed Coiled-coil domain-containing protein 169 Ccdc169 Mus musculus (Mouse) 214 0 0 0 0 0 PF15372; Q8BYU6 CHOYP_LOC100367949.1.3 m.49137 sp TOIP2_MOUSE 24.265 272 149 13 94 344 249 484 1.20E-06 53.9 TOIP2_MOUSE reviewed Torsin-1A-interacting protein 2 Tor1aip2 Ifrg15 Lull1 Mus musculus (Mouse) 502 endoplasmic reticulum organization [GO:0007029]; positive regulation of ATPase activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435] GO:0001671; GO:0005635; GO:0005783; GO:0005789; GO:0007029; GO:0016021; GO:0032781; GO:0051117; GO:0090435 0 0 0 PF05609; Q8IR45 CHOYP_AGAP_AGAP008600.1.1 m.55090 sp BORC8_DROME 47.222 108 57 0 60 167 2 109 1.20E-31 115 BORC8_DROME reviewed BLOC-1-related complex subunit 8 homolog CG32590 Drosophila melanogaster (Fruit fly) 183 0 0 0 0 0 PF10167; Q8IZ81 CHOYP_LOC100366668.1.1 m.778 sp ELMD2_HUMAN 46.154 195 104 1 10 204 6 199 1.20E-51 172 ELMD2_HUMAN reviewed ELMO domain-containing protein 2 ELMOD2 Homo sapiens (Human) 293 defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688] GO:0005096; GO:0016020; GO:0050688; GO:0051607 0 0 0 PF04727; Q8NE22 CHOYP_LOC100705194.1.1 m.35270 sp SETD9_HUMAN 48.973 292 124 6 11 282 12 298 1.20E-88 268 SETD9_HUMAN reviewed SET domain-containing protein 9 (EC 2.1.1.-) SETD9 C5orf35 Homo sapiens (Human) 299 regulation of signal transduction by p53 class mediator [GO:1901796] GO:0005654; GO:0016278; GO:1901796 0 0 0 0 Q8UWA5 CHOYP_CA2.1.1 m.27846 sp CAH2_TRIHK 44.015 259 134 5 59 310 5 259 1.20E-72 228 CAH2_TRIHK reviewed Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) 260 one-carbon metabolic process [GO:0006730] GO:0004089; GO:0005737; GO:0005886; GO:0006730; GO:0008270 0 0 0 PF00194; Q8VE97 CHOYP_RS3A.4.15 m.15366 sp SRSF4_MOUSE 58.786 313 114 5 4 313 3 303 1.20E-97 300 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q92005 CHOYP_EF1A2.1.3 m.30027 sp EF1A_DANRE 94.048 84 5 0 1 84 1 84 1.20E-50 168 EF1A_DANRE reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Danio rerio (Zebrafish) (Brachydanio rerio) 462 0 GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737 0 0 0 PF03144;PF03143; Q94407 CHOYP_PHUM_PHUM460970.1.1 m.19458 sp NHR48_CAEEL 57.576 99 41 1 22 120 90 187 1.20E-35 132 NHR48_CAEEL reviewed Nuclear hormone receptor family member nhr-48 nhr-48 ZK662.3 Caenorhabditis elegans 817 "steroid hormone mediated signaling pathway [GO:0043401]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0008270; GO:0043401; GO:0043565 0 0 0 PF00105; Q96FN5 CHOYP_BRAFLDRAFT_218483.1.1 m.61342 sp KIF12_HUMAN 41.27 315 150 5 408 720 209 490 1.20E-55 207 KIF12_HUMAN reviewed Kinesin-like protein KIF12 KIF12 Homo sapiens (Human) 646 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887; GO:0070062 0 0 0 PF00225; Q96MS3 CHOYP_GL1D1.2.3 m.38247 sp GL1D1_HUMAN 39.655 232 138 2 14 245 76 305 1.20E-54 182 GL1D1_HUMAN reviewed Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) GLT1D1 Homo sapiens (Human) 346 0 GO:0005576; GO:0005737; GO:0016757 0 0 0 PF00534; Q99315 CHOYP_LOC100894010.6.6 m.43992 sp YG31B_YEAST 46.429 168 86 2 98 265 585 748 1.20E-38 147 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q99MQ3 CHOYP_SACS.5.17 m.34874 sp PINK1_MOUSE 36.951 387 201 6 768 1147 155 505 1.20E-71 254 PINK1_MOUSE reviewed "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" Pink1 Mus musculus (Mouse) 580 "cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; establishment of protein localization to mitochondrion [GO:0072655]; intracellular signal transduction [GO:0035556]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000422]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of macroautophagy [GO:0016242]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1903147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced cell death [GO:1903202]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of histone deacetylase activity [GO:1901727]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of neuron apoptotic process [GO:0043523]; regulation of oxidative phosphorylation [GO:0002082]; regulation of protein complex assembly [GO:0043254]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979]; response to stress [GO:0006950]" GO:0000287; GO:0000422; GO:0000785; GO:0001934; GO:0002020; GO:0002082; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005742; GO:0005743; GO:0005758; GO:0005829; GO:0005856; GO:0006468; GO:0006950; GO:0006979; GO:0007005; GO:0010310; GO:0010629; GO:0010821; GO:0010857; GO:0016020; GO:0016239; GO:0016242; GO:0016301; GO:0016567; GO:0018105; GO:0022904; GO:0030424; GO:0031307; GO:0031396; GO:0031625; GO:0031932; GO:0032226; GO:0033138; GO:0033603; GO:0033605; GO:0034599; GO:0035307; GO:0035556; GO:0036289; GO:0043123; GO:0043254; GO:0043422; GO:0043523; GO:0043524; GO:0044297; GO:0045727; GO:0048471; GO:0050821; GO:0051091; GO:0051881; GO:0055131; GO:0071456; GO:0072655; GO:0072656; GO:0090141; GO:0090200; GO:0090258; GO:0097237; GO:0097449; GO:0098779; GO:1901727; GO:1902902; GO:1902958; GO:1903147; GO:1903202; GO:1903214; GO:1903298; GO:1903384; GO:1903751; GO:1903852; GO:1903955; GO:2000377; GO:2000378 0 0 0 PF00069; Q9CL21 CHOYP_LOC100370129.4.4 m.59428 sp RECQ_PASMU 28.4 250 153 8 2 251 131 354 1.20E-25 109 RECQ_PASMU reviewed ATP-dependent DNA helicase RecQ (EC 3.6.4.12) recQ PM1427 Pasteurella multocida (strain Pm70) 632 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432] GO:0003677; GO:0005524; GO:0005622; GO:0006260; GO:0006281; GO:0006310; GO:0009432; GO:0043140 0 0 0 PF00270;PF00271;PF00570;PF16124;PF09382; Q9DE46 CHOYP_POLA1.1.1 m.50360 sp DPOLA_XENLA 40.571 175 104 0 1 175 1284 1458 1.20E-38 143 DPOLA_XENLA reviewed DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) pola1 pola Xenopus laevis (African clawed frog) 1458 "cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272]" GO:0000166; GO:0001882; GO:0003677; GO:0003682; GO:0003887; GO:0005634; GO:0005635; GO:0005654; GO:0005658; GO:0005730; GO:0006260; GO:0006269; GO:0006270; GO:0006271; GO:0006272; GO:0006273; GO:0006303; GO:0008283; GO:0008408; GO:0016363; GO:0046872; GO:0051539 0 0 0 PF12254;PF00136;PF03104;PF08996; Q9EQZ7 CHOYP_LOC100702299.1.1 m.49236 sp RIMS2_MOUSE 30.882 340 199 10 1 327 706 1022 1.20E-22 107 RIMS2_MOUSE reviewed Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2) Rims2 Rab3ip2 Rim2 Mus musculus (Mouse) 1530 calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cAMP-mediated signaling [GO:0019933]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; spontaneous neurotransmitter secretion [GO:0061669] GO:0005622; GO:0006886; GO:0007269; GO:0010628; GO:0017156; GO:0017157; GO:0019933; GO:0030054; GO:0030073; GO:0042391; GO:0043005; GO:0044325; GO:0046872; GO:0048786; GO:0048791; GO:0061669; GO:0070062; GO:0097151; GO:1903861; GO:2000463 0 0 0 PF00168;PF02318; Q9HB75 CHOYP_PIDD.1.1 m.54294 sp PIDD1_HUMAN 23.729 177 129 2 408 584 368 538 1.20E-08 62.8 PIDD1_HUMAN reviewed p53-induced death domain-containing protein 1 (Leucine-rich repeat and death domain-containing protein) PIDD1 LRDD PIDD Homo sapiens (Human) 910 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to DNA damage stimulus [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]" GO:0005123; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006915; GO:0006919; GO:0006974; GO:0006977; GO:0007165; GO:0042981; GO:0043065; GO:0043066; GO:0051092; GO:1902043 0 0 0 PF00531;PF13855;PF10461;PF00791; Q9I9K7 CHOYP_TBX20.2.4 m.10081 sp TBX20_DANRE 58.991 317 115 5 13 327 6 309 1.20E-120 361 TBX20_DANRE reviewed T-box transcription factor TBX20 (T-box protein 20) (H15-related T-box transcription factor hrT) tbx20 Danio rerio (Zebrafish) (Brachydanio rerio) 446 "blood vessel development [GO:0001568]; cloaca development [GO:0035844]; embryonic heart tube development [GO:0035050]; embryonic hemopoiesis [GO:0035162]; heart development [GO:0007507]; heart looping [GO:0001947]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]; vasculogenesis [GO:0001570]" GO:0001568; GO:0001570; GO:0001947; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007507; GO:0035050; GO:0035162; GO:0035844; GO:0045892 0 0 0 PF00907; Q9IBG7 CHOYP_BRAFLDRAFT_74063.5.5 m.47803 sp KCP_XENLA 40.461 304 169 6 5 299 986 1286 1.20E-55 197 KCP_XENLA reviewed Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) 2327 0 GO:0005576 0 0 0 PF00093;PF00094; Q9QUN3 CHOYP_PHUM_PHUM128460.4.7 m.38295 sp BLNK_MOUSE 34.513 113 70 3 496 605 342 453 1.20E-14 80.1 BLNK_MOUSE reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) Blnk Bash Ly57 Slp65 Mus musculus (Mouse) 457 B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005737; GO:0005886; GO:0006955; GO:0035556; GO:0042113 0 0 0 PF00017; Q9QX22 CHOYP_RAC1.1.3 m.20870 sp TPMT_MUSSP 34.052 232 144 6 6 228 7 238 1.20E-33 124 TPMT_MUSSP reviewed Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) Tpmt Mus spretus (Western Mediterranean mouse) (Algerian mouse) 240 0 GO:0005737; GO:0008119; GO:0070062 0 0 0 PF05724; Q9ULC3 CHOYP_ABCA4.1.1 m.31462 sp RAB23_HUMAN 62.241 241 75 2 1 241 1 225 1.20E-100 296 RAB23_HUMAN reviewed Ras-related protein Rab-23 RAB23 HSPC137 Homo sapiens (Human) 237 autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0042384]; craniofacial suture morphogenesis [GO:0097094]; negative regulation of transcription factor import into nucleus [GO:0042992]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000045; GO:0003924; GO:0005525; GO:0005737; GO:0005776; GO:0005886; GO:0006968; GO:0007264; GO:0010008; GO:0015031; GO:0030670; GO:0042384; GO:0042992; GO:0045335; GO:0070062; GO:0097094 0 0 0 PF00071; Q9ULC3 CHOYP_BRAFLDRAFT_62225.1.1 m.55568 sp RAB23_HUMAN 62.241 241 75 2 1 241 1 225 1.20E-100 296 RAB23_HUMAN reviewed Ras-related protein Rab-23 RAB23 HSPC137 Homo sapiens (Human) 237 autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0042384]; craniofacial suture morphogenesis [GO:0097094]; negative regulation of transcription factor import into nucleus [GO:0042992]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000045; GO:0003924; GO:0005525; GO:0005737; GO:0005776; GO:0005886; GO:0006968; GO:0007264; GO:0010008; GO:0015031; GO:0030670; GO:0042384; GO:0042992; GO:0045335; GO:0070062; GO:0097094 0 0 0 PF00071; Q9VCA8 CHOYP_LOC753709.9.44 m.20594 sp ANKHM_DROME 30.4 375 228 12 787 1149 588 941 1.20E-32 142 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9WV92 CHOYP_E41L3.2.2 m.57999 sp E41L3_MOUSE 58.284 338 136 3 24 361 112 444 1.20E-141 439 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; Q9XSJ0 CHOYP_UCHL5.1.2 m.34066 sp UCHL5_BOVIN 60.44 182 60 2 1 171 148 328 1.20E-71 221 UCHL5_BOVIN reviewed Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) UCHL5 UCH37 Bos taurus (Bovine) 328 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; forebrain morphogenesis [GO:0048853]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; protein deubiquitination [GO:0016579]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0000502; GO:0004843; GO:0004866; GO:0005634; GO:0005737; GO:0005829; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0006511; GO:0016579; GO:0021670; GO:0030901; GO:0031011; GO:0044822; GO:0048853; GO:0061136; GO:0070628 0 0 0 PF01088; A0A0R4IBK5 CHOYP_BRAFLDRAFT_106560.13.14 m.62780 sp R213A_DANRE 28.619 1513 861 52 1802 3153 1891 3345 1.21E-122 443 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A2AJ76 CHOYP_LOC100880815.6.7 m.59941 sp HMCN2_MOUSE 25.282 621 351 27 98 642 3035 3618 1.21E-25 118 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A2ASQ1 CHOYP_AGRIN.4.5 m.27580 sp AGRIN_MOUSE 29.134 254 127 11 148 370 177 408 1.21E-09 63.9 AGRIN_MOUSE reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] Agrn Agrin Mus musculus (Mouse) 1950 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; glycosaminoglycan biosynthetic process [GO:0006024]; multicellular organism development [GO:0007275]; negative regulation of sodium:potassium-exchanging ATPase activity [GO:1903407]; negative regulation of sodium ion export from cell [GO:1903277]; neuromuscular junction development [GO:0007528]; neurotransmitter receptor metabolic process [GO:0045213]; plasma membrane organization [GO:0007009]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein binding [GO:0032092]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of GTPase activity [GO:0043087]; regulation of synaptic growth at neuromuscular junction [GO:0008582] GO:0001934; GO:0002162; GO:0005509; GO:0005576; GO:0005604; GO:0005605; GO:0005615; GO:0005737; GO:0005796; GO:0005886; GO:0006024; GO:0007009; GO:0007268; GO:0007275; GO:0007528; GO:0008582; GO:0009986; GO:0016021; GO:0030054; GO:0030154; GO:0030548; GO:0031012; GO:0032092; GO:0033691; GO:0035374; GO:0042030; GO:0043087; GO:0043113; GO:0043395; GO:0043525; GO:0043547; GO:0044325; GO:0045202; GO:0045213; GO:0045887; GO:0045944; GO:0051491; GO:0055117; GO:0061098; GO:0070062; GO:0086036; GO:1903277; GO:1903407; GO:2000541 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF01390; A2BGM5 CHOYP_FOXN1.1.1 m.8361 sp FOXN4_DANRE 74.79 119 29 1 202 320 225 342 1.21E-57 201 FOXN4_DANRE reviewed Forkhead box protein N4 foxn4 sli slipjig Danio rerio (Zebrafish) (Brachydanio rerio) 550 "amacrine cell differentiation [GO:0035881]; atrioventricular canal development [GO:0036302]; heart looping [GO:0001947]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of heart contraction [GO:0008016]; regulation of transcription, DNA-templated [GO:0006355]; retina layer formation [GO:0010842]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron fate commitment [GO:0060579]" GO:0001158; GO:0001947; GO:0003682; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0008016; GO:0010842; GO:0035881; GO:0036302; GO:0043565; GO:0045893; GO:0060579 0 0 0 PF00250; A4IF63 CHOYP_BRAFLDRAFT_84665.2.3 m.32743 sp TRIM2_BOVIN 32.759 116 75 2 24 136 627 742 1.21E-10 61.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4QN59 CHOYP_BRAFLDRAFT_225211.1.1 m.14894 sp DPH2_DANRE 48.29 497 233 9 3 489 4 486 1.21E-156 457 DPH2_DANRE reviewed Diphthamide biosynthesis protein 2 (DPH2 homolog) dph2 zgc:162269 Danio rerio (Zebrafish) (Brachydanio rerio) 498 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183] GO:0017183 PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. 0 0 PF01866; A5D6U8 CHOYP_DANA_GF20208.1.1 m.9661 sp ACP7_DANRE 40.802 424 215 11 27 429 31 439 1.21E-97 306 ACP7_DANRE reviewed Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form) acp7 papl zgc:162913 Danio rerio (Zebrafish) (Brachydanio rerio) 443 0 GO:0003993; GO:0005576; GO:0046872 0 0 0 PF00149;PF14008;PF16656; B2RUP2 CHOYP_TRIADDRAFT_60504.1.1 m.3067 sp UN13D_MOUSE 24.085 328 208 11 92 407 50 348 1.21E-07 58.9 UN13D_MOUSE reviewed Protein unc-13 homolog D (Munc13-4) Unc13d Mus musculus (Mouse) 1085 defense response to virus [GO:0051607]; germinal center formation [GO:0002467]; granuloma formation [GO:0002432]; natural killer cell degranulation [GO:0043320]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of mast cell degranulation [GO:0043304] GO:0002432; GO:0002467; GO:0005764; GO:0005770; GO:0006909; GO:0016020; GO:0017137; GO:0033093; GO:0043304; GO:0043320; GO:0045921; GO:0051607; GO:0055037; GO:0070382; GO:1900026; GO:1903307 0 0 0 PF00168;PF10540; C3ZAH2 CHOYP_MTND.2.3 m.41824 sp MTND_BRAFL 64.804 179 61 1 24 202 1 177 1.21E-85 253 MTND_BRAFL reviewed "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD)" BRAFLDRAFT_119977 Branchiostoma floridae (Florida lancelet) (Amphioxus) 177 L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555] GO:0005506; GO:0005634; GO:0005737; GO:0006555; GO:0010309; GO:0019509 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. {ECO:0000255|HAMAP-Rule:MF_03154}. 0 0 PF03079; D2GXS7 CHOYP_contig_022206 m.25442 sp TRIM2_AILME 26.63 184 115 5 153 329 521 691 1.21E-06 53.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F8RP11 CHOYP_LOC100661737.2.2 m.64672 sp HSOP_WHEAT 32.381 105 60 2 153 257 393 486 1.21E-08 62 HSOP_WHEAT reviewed Hsp70-Hsp90 organizing protein (TaHop) HOP Triticum aestivum (Wheat) 581 chaperone-mediated protein complex assembly [GO:0051131] GO:0005634; GO:0005737; GO:0051131; GO:0051879; GO:0070678 0 0 0 PF13414;PF07719;PF13181; G4SLH0 CHOYP_CELE_T04A8.13.1.1 m.54119 sp TTN1_CAEEL 29.365 126 89 0 33 158 7005 7130 1.21E-08 56.6 TTN1_CAEEL reviewed Titin homolog (EC 2.7.11.1) ttn-1 W06H8.8 Caenorhabditis elegans 18562 actin filament organization [GO:0007015]; sarcomere organization [GO:0045214]; striated muscle contraction [GO:0006941]; striated muscle myosin thick filament assembly [GO:0071688] GO:0004674; GO:0005524; GO:0005859; GO:0005865; GO:0006941; GO:0007015; GO:0008307; GO:0030018; GO:0031430; GO:0031672; GO:0031674; GO:0031965; GO:0045214; GO:0046872; GO:0051015; GO:0051371; GO:0071688; GO:0097493 0 0 0 PF00041;PF07679;PF00069; H2A0M5 CHOYP_USP2.1.1 m.44411 sp USP2_PINMG 31.646 237 123 9 7 236 7 211 1.21E-23 98.2 USP2_PINMG reviewed Uncharacterized shell protein 2 (Prism uncharacterized shell protein 10) (PUSP10) 0 Pinctada margaritifera (Black-lipped pearl oyster) 225 0 GO:0005576 0 0 0 0 I0IUP3 CHOYP_LOC100377194.1.2 m.8453 sp MCM8_CHICK 51.743 373 156 7 26 385 62 423 1.21E-132 402 MCM8_CHICK reviewed DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) MCM8 RCJMB04_5o15 Gallus gallus (Chicken) 830 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; female gamete generation [GO:0007292]; male gamete generation [GO:0048232] GO:0000724; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0006260; GO:0006974; GO:0007292; GO:0048232; GO:0097362 0 0 0 PF00493; O43447 CHOYP_PPIH.1.1 m.18923 sp PPIH_HUMAN 80.347 173 33 1 33 205 6 177 1.21E-101 294 PPIH_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) PPIH CYP20 CYPH Homo sapiens (Human) 177 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein complex assembly [GO:0006461]; protein folding [GO:0006457]" GO:0000398; GO:0003755; GO:0005654; GO:0005681; GO:0005737; GO:0006457; GO:0006461; GO:0016018; GO:0016607; GO:0043021; GO:0045070; GO:0046540; GO:0071001 0 0 0 PF00160; O60683 CHOYP_PEX10.1.2 m.7915 sp PEX10_HUMAN 40.81 321 153 5 6 290 6 325 1.21E-78 244 PEX10_HUMAN reviewed Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69) PEX10 RNF69 Homo sapiens (Human) 326 peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558] GO:0005622; GO:0005777; GO:0005778; GO:0005779; GO:0007031; GO:0008022; GO:0008270; GO:0016558 0 0 0 PF04757; O73791 CHOYP_SREC2.7.9 m.44662 sp TIE2_DANRE 30.37 135 59 5 24 144 214 327 1.21E-09 61.2 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O73853 CHOYP_LOC100368684.1.1 m.13298 sp CP17A_ICTPU 34.8 500 303 11 61 542 5 499 1.21E-86 280 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; O75342 CHOYP_LOC584481.7.10 m.57390 sp LX12B_HUMAN 30.533 488 272 18 140 593 247 701 1.21E-48 183 LX12B_HUMAN reviewed "Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)" ALOX12B Homo sapiens (Human) 701 arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipoxygenase pathway [GO:0019372]; oxidation-reduction process [GO:0055114]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665] GO:0004052; GO:0005506; GO:0005829; GO:0006497; GO:0006665; GO:0010628; GO:0016702; GO:0019369; GO:0019372; GO:0043410; GO:0043651; GO:0046513; GO:0051122; GO:0055114; GO:0061436; GO:0070257; GO:1990136 PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:21558561}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:21558561}. 0 0 PF00305;PF01477; O75382 CHOYP_BRAFLDRAFT_84670.2.3 m.46764 sp TRIM3_HUMAN 26.119 268 169 13 211 462 488 742 1.21E-08 61.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75689 CHOYP_RLA0.3.7 m.42195 sp ADAP1_HUMAN 42.35 366 200 5 3 363 4 363 1.21E-112 336 ADAP1_HUMAN reviewed Arf-GAP with dual PH domain-containing protein 1 (Centaurin-alpha-1) (Cnt-a1) (Putative MAPK-activating protein PM25) ADAP1 CENTA1 Homo sapiens (Human) 374 cell surface receptor signaling pathway [GO:0007166]; regulation of GTPase activity [GO:0043087] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0007166; GO:0043087; GO:0043533; GO:0046872 0 0 0 PF01412;PF00169; O75897 CHOYP_ST1C1.1.1 m.45503 sp ST1C4_HUMAN 37.943 282 147 12 28 296 35 301 1.21E-46 161 ST1C4_HUMAN reviewed Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) 302 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; sulfation [GO:0051923] GO:0004062; GO:0005829; GO:0008146; GO:0050427; GO:0051923 0 0 0 PF00685; O77834 CHOYP_NEMVEDRAFT_V1G234225.1.1 m.49490 sp PRDX6_BOVIN 66.822 214 70 1 4 216 7 220 1.21E-102 300 PRDX6_BOVIN reviewed Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Ciliary body glutathione peroxidase) (Non-selenium glutathione peroxidase) (NSGPx) (EC 1.11.1.9) (PHGPx) PRDX6 AOP2 GPX PHGPX Bos taurus (Bovine) 224 cell redox homeostasis [GO:0045454]; phospholipid catabolic process [GO:0009395]; response to reactive oxygen species [GO:0000302] GO:0000302; GO:0004601; GO:0004602; GO:0004623; GO:0005615; GO:0005737; GO:0005764; GO:0005829; GO:0009395; GO:0016020; GO:0016023; GO:0045454; GO:0051920; GO:0070062 0 0 0 PF10417;PF00578; O88626 CHOYP_LOC762961.2.5 m.37322 sp GALR3_RAT 31.973 147 95 2 69 210 26 172 1.21E-08 60.1 GALR3_RAT reviewed Galanin receptor type 3 (GAL3-R) (GALR-3) Galr3 Galnr3 Rattus norvegicus (Rat) 370 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of cAMP biosynthetic process [GO:0030818]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0004966; GO:0005887; GO:0007193; GO:0007194; GO:0007200; GO:0007218; GO:0017046; GO:0030818; GO:0045944 0 0 0 PF00001; P0C0T1 CHOYP_ITPK1.1.1 m.10140 sp ITPK1_BOVIN 42.133 375 207 6 2 370 8 378 1.21E-99 305 ITPK1_BOVIN reviewed "Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase) (Inositol-triphosphate 5/6-kinase) (Ins(1,3,4)P(3) 5/6-kinase) (EC 2.7.1.159)" ITPK1 Bos taurus (Bovine) 419 inositol trisphosphate metabolic process [GO:0032957]; neural tube development [GO:0021915] GO:0000287; GO:0005524; GO:0005622; GO:0016324; GO:0016787; GO:0016853; GO:0021915; GO:0032957; GO:0047325; GO:0052725; GO:0052726 0 0 0 PF05770; P0C6P7 CHOYP_LOC101156232.1.1 m.10300 sp FEM1B_RAT 34.146 123 71 5 529 650 514 627 1.21E-06 55.5 FEM1B_RAT reviewed Protein fem-1 homolog B (FEM1b) (FEM1-beta) Fem1b Rattus norvegicus (Rat) 627 apoptotic process [GO:0006915]; branching involved in prostate gland morphogenesis [GO:0060442]; epithelial cell maturation involved in prostate gland development [GO:0060743]; regulation of DNA damage checkpoint [GO:2000001]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of ubiquitin-protein transferase activity [GO:0051438] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006915; GO:0051438; GO:0060442; GO:0060743; GO:1902041; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00023;PF12796; P18203 CHOYP_FKB12.1.1 m.29167 sp FKB1A_BOVIN 50.459 109 50 2 20 127 3 108 1.21E-25 102 FKB1A_BOVIN reviewed Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) FKBP1A FKBP1 Bos taurus (Bovine) 108 amyloid fibril formation [GO:1990000]; chaperone-mediated protein folding [GO:0061077]; cytokine-mediated signaling pathway [GO:0019221]; extracellular fibril organization [GO:0043206]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; muscle contraction [GO:0006936]; negative regulation of protein phosphatase type 2B activity [GO:0032513]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; release of sequestered calcium ion into cytosol [GO:0051209]; response to caffeine [GO:0031000]; SMAD protein complex assembly [GO:0007183]; T cell activation [GO:0042110]; T cell proliferation [GO:0042098]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] GO:0000413; GO:0001933; GO:0003007; GO:0003755; GO:0004871; GO:0005528; GO:0005737; GO:0005789; GO:0005829; GO:0006936; GO:0007183; GO:0008144; GO:0016020; GO:0019221; GO:0019855; GO:0030018; GO:0031000; GO:0031012; GO:0031398; GO:0032092; GO:0032513; GO:0032880; GO:0032925; GO:0033017; GO:0042098; GO:0042110; GO:0042803; GO:0043123; GO:0043206; GO:0044325; GO:0046332; GO:0048185; GO:0050776; GO:0051209; GO:0051280; GO:0055010; GO:0060314; GO:0060315; GO:0060347; GO:0061077; GO:0070062; GO:1902991; GO:1990000 0 0 0 PF00254; P18503 CHOYP_BRAFLDRAFT_76550.6.21 m.47254 sp CAS4_EPHMU 34.921 126 58 5 59 179 207 313 1.21E-08 58.2 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P21783 CHOYP_SNED1.2.4 m.43644 sp NOTC1_XENLA 34.459 148 70 9 33 172 207 335 1.21E-10 62.8 NOTC1_XENLA reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (xOTCH) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 xotch Xenopus laevis (African clawed frog) 2524 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001525; GO:0004872; GO:0005509; GO:0005654; GO:0005886; GO:0006351; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P23757 CHOYP_LOC100377317.1.1 m.18703 sp POXM_DROME 33.333 108 70 2 21 127 31 137 1.21E-08 59.3 POXM_DROME reviewed Paired box pox-meso protein (Paired box mesodermal protein) Poxm POX-M CG9610 Drosophila melanogaster (Fruit fly) 370 "dendrite morphogenesis [GO:0048813]; larval somatic muscle development [GO:0007526]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007526; GO:0048813 0 0 0 PF00292; P24367 CHOYP_TSP_03740.1.1 m.61194 sp PPIB_CHICK 58.564 181 69 2 46 226 30 204 1.21E-72 223 PPIB_CHICK reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207 chaperone-mediated protein folding [GO:0061077]; protein peptidyl-prolyl isomerization [GO:0000413] GO:0000413; GO:0003755; GO:0005788; GO:0032403; GO:0032991; GO:0042277; GO:0042470; GO:0061077 0 0 0 PF00160; P26009 CHOYP_ITA5.1.1 m.55930 sp ITA8_CHICK 24.125 1086 679 49 17 1022 22 1042 1.21E-44 179 ITA8_CHICK reviewed Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Gallus gallus (Chicken) 1044 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; integrin-mediated signaling pathway [GO:0007229]; nervous system development [GO:0007399] GO:0007155; GO:0007229; GO:0007399; GO:0008305; GO:0030154; GO:0046872 0 0 0 PF01839;PF00357;PF08441; P29594 CHOYP_LOC100892193.3.5 m.58698 sp CASP2_MOUSE 26.835 395 252 9 240 608 65 448 1.21E-35 142 CASP2_MOUSE reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Casp2 Ich1 Nedd-2 Nedd2 Mus musculus (Mouse) 452 "aging [GO:0007568]; apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]" GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0006977; GO:0007420; GO:0007568; GO:0016020; GO:0016485; GO:0019904; GO:0035234; GO:0043065; GO:0043066; GO:0043525; GO:0071260; GO:0097153; GO:0097190; GO:0097192; GO:2001235 0 0 0 PF00619; P41233 CHOYP_ABCA1.2.3 m.11687 sp ABCA1_MOUSE 40 675 344 13 258 903 1180 1822 1.21E-130 437 ABCA1_MOUSE reviewed ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) Abca1 Abc1 Mus musculus (Mouse) 2261 "cellular response to cholesterol [GO:0071397]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; G-protein coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; interleukin-1 beta secretion [GO:0050702]; intracellular cholesterol transport [GO:0032367]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cholesterol efflux [GO:0010875]; protein lipidation [GO:0006497]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to drug [GO:0042493]; response to laminar fluid shear stress [GO:0034616]; response to low-density lipoprotein particle [GO:0055098]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]" GO:0002790; GO:0005102; GO:0005524; GO:0005548; GO:0005794; GO:0005886; GO:0005887; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007584; GO:0008203; GO:0008509; GO:0009897; GO:0010875; GO:0016197; GO:0017127; GO:0019905; GO:0030139; GO:0030819; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034364; GO:0034380; GO:0034616; GO:0042157; GO:0042158; GO:0042493; GO:0042626; GO:0042632; GO:0043231; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0048471; GO:0050702; GO:0051117; GO:0055091; GO:0055098; GO:0060155; GO:0071222; GO:0071300; GO:0071397 0 0 0 PF00005; P49282 CHOYP_LOC100891619.1.1 m.28614 sp NRAM2_MOUSE 56.15 374 140 3 9 358 126 499 1.21E-134 401 NRAM2_MOUSE reviewed Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) Slc11a2 Dct1 Dmt1 Nramp2 Mus musculus (Mouse) 568 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cadmium ion transmembrane transport [GO:0070574]; cellular response to oxidative stress [GO:0034599]; cobalt ion transport [GO:0006824]; copper ion transport [GO:0006825]; dendrite morphogenesis [GO:0048813]; detection of oxygen [GO:0003032]; erythrocyte development [GO:0048821]; ferrous iron import [GO:0070627]; ferrous iron transport [GO:0015684]; heme biosynthetic process [GO:0006783]; iron ion transport [GO:0006826]; lead ion transport [GO:0015692]; learning or memory [GO:0007611]; manganese ion transport [GO:0006828]; multicellular organismal iron ion homeostasis [GO:0060586]; porphyrin-containing compound biosynthetic process [GO:0006779]; porphyrin-containing compound metabolic process [GO:0006778]; proton transport [GO:0015992]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039] GO:0001666; GO:0003032; GO:0005375; GO:0005381; GO:0005384; GO:0005385; GO:0005634; GO:0005737; GO:0005741; GO:0005765; GO:0005768; GO:0005769; GO:0005773; GO:0005802; GO:0005886; GO:0005887; GO:0005903; GO:0006778; GO:0006779; GO:0006783; GO:0006824; GO:0006825; GO:0006826; GO:0006828; GO:0006919; GO:0007611; GO:0009986; GO:0010039; GO:0012505; GO:0015078; GO:0015086; GO:0015087; GO:0015093; GO:0015094; GO:0015099; GO:0015100; GO:0015295; GO:0015639; GO:0015684; GO:0015692; GO:0015992; GO:0016020; GO:0016324; GO:0030904; GO:0031410; GO:0031526; GO:0031902; GO:0034599; GO:0045177; GO:0045178; GO:0046870; GO:0046915; GO:0048471; GO:0048813; GO:0048821; GO:0055037; GO:0060586; GO:0070574; GO:0070627; GO:0070826 0 0 0 PF01566; P60889 CHOYP_LOC100564588.1.1 m.25475 sp CBX7_RAT 51.389 72 34 1 1 72 1 71 1.21E-16 79 CBX7_RAT reviewed Chromobox protein homolog 7 Cbx7 Rattus norvegicus (Rat) 158 "covalent chromatin modification [GO:0016569]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; response to drug [GO:0042493]; sebaceous gland development [GO:0048733]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0000792; GO:0003682; GO:0003727; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0016569; GO:0031519; GO:0035102; GO:0042493; GO:0048733 0 0 0 PF00385; P61354 CHOYP_LOC100373506.5.8 m.40811 sp RL27_RAT 81.618 136 25 0 1 136 1 136 1.21E-79 234 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; P80109 CHOYP_CAOG_04498.1.1 m.29694 sp PHLD_BOVIN 41.844 141 80 2 22 160 25 165 1.21E-32 125 PHLD_BOVIN reviewed Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) 839 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytolysis [GO:0045919]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633] GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0005578; GO:0005615; GO:0005737; GO:0006507; GO:0008285; GO:0008286; GO:0009749; GO:0010595; GO:0010694; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0032869; GO:0034364; GO:0035690; GO:0035774; GO:0043065; GO:0043231; GO:0045919; GO:0046470; GO:0051044; GO:0051047; GO:0070633; GO:0071277; GO:0071397; GO:0071401; GO:0071467; GO:1900076 0 0 0 PF01839;PF00882; P86854 CHOYP_PLCL.5.8 m.63913 sp PLCL_MYTGA 32.99 97 49 4 19 103 17 109 1.21E-07 50.1 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q06805 CHOYP_LOC579946.23.24 m.59308 sp TIE1_BOVIN 37.5 88 45 5 217 296 218 303 1.21E-08 59.7 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q08E39 CHOYP_SPY2.1.1 m.57604 sp SPY2_BOVIN 41.765 170 89 4 73 236 145 310 1.21E-33 126 SPY2_BOVIN reviewed Protein sprouty homolog 2 (Spry-2) SPRY2 Bos taurus (Bovine) 315 bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; establishment of mitotic spindle orientation [GO:0000132]; inner ear morphogenesis [GO:0042472]; lung growth [GO:0060437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell projection organization [GO:0031345]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of GTPase activity [GO:0034260]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of cell differentiation [GO:0045595]; sensory perception of sound [GO:0007605] GO:0000132; GO:0005634; GO:0005829; GO:0005874; GO:0007605; GO:0008285; GO:0010628; GO:0010801; GO:0031345; GO:0032587; GO:0033138; GO:0034260; GO:0040037; GO:0042472; GO:0043066; GO:0043407; GO:0043539; GO:0045165; GO:0045595; GO:0046580; GO:0051387; GO:0051897; GO:0060437; GO:0060449; GO:0070373; GO:0070374 0 0 0 PF05210; Q09472 CHOYP_CBP.4.4 m.37467 sp EP300_HUMAN 63.529 85 31 0 35 119 563 647 1.21E-33 127 EP300_HUMAN reviewed Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) EP300 P300 Homo sapiens (Human) 2414 "apoptotic process [GO:0006915]; B cell differentiation [GO:0030183]; beta-catenin-TCF complex assembly [GO:1904837]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to drug [GO:0035690]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to mineralocorticoid stimulus [GO:0071389]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to retinoic acid [GO:0071300]; cellular response to trichostatin A [GO:0035984]; cellular response to UV [GO:0034644]; circadian rhythm [GO:0007623]; digestive tract development [GO:0048565]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; histone H2B acetylation [GO:0043969]; histone H3 acetylation [GO:0043966]; histone H4 acetylation [GO:0043967]; internal peptidyl-lysine acetylation [GO:0018393]; internal protein amino acid acetylation [GO:0006475]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; liver development [GO:0001889]; lung development [GO:0030324]; macrophage derived foam cell differentiation [GO:0010742]; megakaryocyte development [GO:0035855]; memory [GO:0007613]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of miRNA metabolic process [GO:2000629]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; N-terminal peptidyl-lysine acetylation [GO:0018076]; organ morphogenesis [GO:0009887]; platelet formation [GO:0030220]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of axon extension [GO:0045773]; positive regulation of cell death [GO:0010942]; positive regulation of cell size [GO:0045793]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of histone acetylation [GO:0035066]; positive regulation of muscle atrophy [GO:0014737]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of proteolysis [GO:0045862]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; positive regulation of translation [GO:0045727]; positive regulation of type I interferon production [GO:0032481]; protein acetylation [GO:0006473]; protein-DNA complex assembly [GO:0065004]; protein kinase B signaling [GO:0043491]; protein stabilization [GO:0050821]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of angiotensin metabolic process [GO:0060177]; regulation of autophagy [GO:0010506]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of tubulin deacetylation [GO:0090043]; response to calcium ion [GO:0051592]; response to cobalt ion [GO:0032025]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to tumor necrosis factor [GO:0034612]; skeletal muscle tissue development [GO:0007519]; somitogenesis [GO:0001756]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transcription-coupled nucleotide-excision repair [GO:0006283]; viral process [GO:0016032]" GO:0000122; GO:0000123; GO:0000785; GO:0000978; GO:0000979; GO:0001047; GO:0001102; GO:0001228; GO:0001666; GO:0001756; GO:0001889; GO:0001934; GO:0002223; GO:0003677; GO:0003682; GO:0003684; GO:0003713; GO:0003823; GO:0004402; GO:0004468; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006283; GO:0006355; GO:0006473; GO:0006475; GO:0006915; GO:0006977; GO:0006990; GO:0007219; GO:0007399; GO:0007507; GO:0007519; GO:0007613; GO:0007623; GO:0008013; GO:0008022; GO:0008134; GO:0008270; GO:0009887; GO:0010506; GO:0010560; GO:0010742; GO:0010942; GO:0014737; GO:0016032; GO:0016407; GO:0016746; GO:0018076; GO:0018393; GO:0030183; GO:0030220; GO:0030324; GO:0031490; GO:0032025; GO:0032092; GO:0032481; GO:0032967; GO:0032993; GO:0033160; GO:0033613; GO:0034212; GO:0034612; GO:0034644; GO:0035066; GO:0035257; GO:0035690; GO:0035855; GO:0035984; GO:0042771; GO:0043154; GO:0043388; GO:0043491; GO:0043627; GO:0043923; GO:0043966; GO:0043967; GO:0043969; GO:0045444; GO:0045471; GO:0045727; GO:0045773; GO:0045793; GO:0045815; GO:0045862; GO:0045944; GO:0048565; GO:0050681; GO:0050714; GO:0050821; GO:0051091; GO:0051592; GO:0051726; GO:0060177; GO:0060298; GO:0060765; GO:0061418; GO:0065004; GO:0070301; GO:0070542; GO:0071300; GO:0071320; GO:0071333; GO:0071389; GO:0071549; GO:0090043; GO:0097157; GO:1900034; GO:1901796; GO:1904837; GO:1990090; GO:2000629 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q0P6H9 CHOYP_TRIADDRAFT_1234.1.1 m.25035 sp TMM62_HUMAN 45.455 363 183 5 46 397 52 410 1.21E-103 323 TMM62_HUMAN reviewed Transmembrane protein 62 TMEM62 Homo sapiens (Human) 643 0 GO:0016021; GO:0016787 0 0 0 PF00149; Q0VCJ7 CHOYP_LOC664374.1.1 m.31984 sp RERG_BOVIN 41.398 186 93 3 15 200 2 171 1.21E-41 143 RERG_BOVIN reviewed Ras-related and estrogen-regulated growth inhibitor RERG Bos taurus (Bovine) 199 negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0005829; GO:0007264; GO:0008285; GO:0009725; GO:0016020; GO:0030308 0 0 0 PF00071; Q12955 CHOYP_AASI_1435.26.35 m.56762 sp ANK3_HUMAN 30.357 280 184 6 686 965 407 675 1.21E-24 115 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q26065 CHOYP_LOC100533357.1.2 m.56850 sp ACT_PLAMG 94.118 187 10 1 3 189 191 376 1.21E-125 361 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q29HY3 CHOYP_CDC42.9.11 m.59064 sp CDC42_DROPS 39.326 178 94 4 5 169 1 177 1.21E-38 134 CDC42_DROPS reviewed Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) 191 maintenance of protein location [GO:0045185]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275; GO:0045185; GO:0045860 0 0 0 PF00071; Q2WEA5 CHOYP_TRPM1.1.4 m.8821 sp TRPM1_RAT 25.338 592 366 13 1 538 672 1241 1.21E-55 206 TRPM1_RAT reviewed Transient receptor potential cation channel subfamily M member 1 (Melastatin-1) Trpm1 Rattus norvegicus (Rat) 1628 calcium ion transport into cytosol [GO:0060402]; cellular response to light stimulus [GO:0071482]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; protein tetramerization [GO:0051262] GO:0005262; GO:0005886; GO:0007216; GO:0016021; GO:0051262; GO:0060402; GO:0071482 0 0 0 PF00520;PF16519; Q3UHR0 CHOYP_LOC100369237.1.3 m.38262 sp BAHC1_MOUSE 62.667 150 55 1 692 841 2476 2624 1.21E-56 216 BAHC1_MOUSE reviewed BAH and coiled-coil domain-containing protein 1 Bahcc1 Kiaa1447 Mus musculus (Mouse) 2643 chromatin silencing [GO:0006342]; heterochromatin assembly [GO:0031507] GO:0000785; GO:0000976; GO:0003682; GO:0005677; GO:0006342; GO:0031507 0 0 0 PF01426; Q4ZJM9 CHOYP_C1QL2.14.32 m.22115 sp C1QL4_MOUSE 32.824 131 79 5 55 181 110 235 1.21E-08 56.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q54F46 CHOYP_LOC755512.4.5 m.33018 sp WARA_DICDI 38.967 213 129 1 27 238 364 576 1.21E-38 145 WARA_DICDI reviewed Homeobox protein Wariai (Homeobox protein 1) (DdHbx-1) warA hbx1 wri DDB_G0291075 Dictyostelium discoideum (Slime mold) 803 "anatomical structure morphogenesis [GO:0009653]; multicellular organism development [GO:0007275]; protein targeting to plasma membrane [GO:0072661]; regulation of cell differentiation [GO:0045595]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007275; GO:0008093; GO:0009653; GO:0030507; GO:0043565; GO:0045595; GO:0072661 0 0 0 PF00023;PF12796;PF00046; Q58DT0 CHOYP_FRRS1.3.3 m.43298 sp ELF5_BOVIN 49.495 99 43 2 234 332 164 255 1.21E-22 98.2 ELF5_BOVIN reviewed ETS-related transcription factor Elf-5 (E74-like factor 5) ELF5 Bos taurus (Bovine) 255 cell differentiation [GO:0030154]; ectodermal cell fate commitment [GO:0001712]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell differentiation [GO:0045596]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; somatic stem cell population maintenance [GO:0035019] GO:0000977; GO:0000981; GO:0001228; GO:0001712; GO:0005634; GO:0005737; GO:0006357; GO:0030154; GO:0035019; GO:0045596; GO:0060644 0 0 0 PF00178;PF02198; Q5I0D1 CHOYP_BRAFLDRAFT_116041.1.1 m.3962 sp GLOD4_RAT 63.636 297 104 3 1 293 1 297 1.21E-140 401 GLOD4_RAT reviewed Glyoxalase domain-containing protein 4 Glod4 Rattus norvegicus (Rat) 298 0 GO:0005739; GO:0070062 0 0 0 0 Q5T5J6 CHOYP_PHUM_PHUM022100.1.1 m.37156 sp SWT1_HUMAN 32.653 196 116 3 120 304 385 575 1.21E-17 86.7 SWT1_HUMAN reviewed Transcriptional protein SWT1 SWT1 C1orf26 Homo sapiens (Human) 900 0 0 0 0 0 PF13638; Q5ZKD5 CHOYP_LOC100377837.1.2 m.7012 sp RRP12_CHICK 44.444 216 120 0 59 274 755 970 1.21E-55 196 RRP12_CHICK reviewed RRP12-like protein RRP12 RCJMB04_11j1 Gallus gallus (Chicken) 1294 0 GO:0005730; GO:0016021; GO:0031965 0 0 0 PF08161; Q5ZMD4 CHOYP_BRAFLDRAFT_213581.1.2 m.46881 sp TRI59_CHICK 31.579 114 65 4 129 235 8 115 1.21E-07 56.6 TRI59_CHICK reviewed Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) 408 cilium assembly [GO:0042384] GO:0005783; GO:0005789; GO:0005813; GO:0005929; GO:0008270; GO:0016021; GO:0030992; GO:0042384 0 0 0 PF00643;PF13445; Q6PCS6 CHOYP_LOC100375189.1.1 m.11409 sp MTFP1_DANRE 56.688 157 67 1 4 160 6 161 1.21E-52 168 MTFP1_DANRE reviewed Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) (MTP18) mtfp1 mtp18 zgc:63910 Danio rerio (Zebrafish) (Brachydanio rerio) 165 apoptotic process [GO:0006915]; mitochondrial fission [GO:0000266] GO:0000266; GO:0005739; GO:0005743; GO:0006915; GO:0016021 0 0 0 PF10558; Q6X862 CHOYP_PC11X.1.2 m.24795 sp PC11X_GORGO 32.216 835 518 19 31 833 28 846 1.21E-108 374 PC11X_GORGO reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) PCDH11X PCDH11 PCDHX Gorilla gorilla gorilla (Western lowland gorilla) 1347 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q6YHK3 CHOYP_TRIADDRAFT_55768.1.2 m.4476 sp CD109_HUMAN 53.763 93 43 0 1 93 904 996 1.21E-32 123 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q6ZRF8 CHOYP_TIF1B.5.10 m.15707 sp RN207_HUMAN 34.066 91 54 4 18 106 103 189 1.21E-08 54.3 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7SY29 CHOYP_SPX2.1.1 m.23016 sp G6PT3_DANRE 68.878 196 61 0 7 202 283 478 1.21E-90 277 G6PT3_DANRE reviewed Glucose-6-phosphate exchanger SLC37A2 (Solute carrier family 37 member 2) slc37a2 zgc:63583 Danio rerio (Zebrafish) (Brachydanio rerio) 494 anion transport [GO:0006820]; carbohydrate transport [GO:0008643]; glucose-6-phosphate transport [GO:0015760]; phosphate ion transmembrane transport [GO:0035435]; transmembrane transport [GO:0055085] GO:0006820; GO:0008643; GO:0015760; GO:0016021; GO:0022857; GO:0030176; GO:0035435; GO:0055085; GO:0061513 0 0 cd06174; PF07690; Q86TN4 CHOYP_BRAFLDRAFT_274539.3.3 m.49552 sp TRPT1_HUMAN 48.858 219 106 3 150 362 4 222 1.21E-61 210 TRPT1_HUMAN reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) TRPT1 Homo sapiens (Human) 253 "regulation of protein kinase activity [GO:0045859]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388; GO:0045859 0 0 0 PF01885; Q8BP40 CHOYP_LOC756773.1.1 m.18230 sp PPA6_MOUSE 29.829 409 254 11 47 450 36 416 1.21E-52 186 PPA6_MOUSE reviewed "Lysophosphatidic acid phosphatase type 6 (EC 3.1.3.2) (Acid phosphatase 6, lysophosphatidic) (Acid phosphatase-like protein 1) (PACPL1)" Acp6 Acpl1 Lpap Mus musculus (Mouse) 418 hematopoietic progenitor cell differentiation [GO:0002244]; lysobisphosphatidic acid metabolic process [GO:2001311]; phospholipid metabolic process [GO:0006644] GO:0002244; GO:0003993; GO:0005737; GO:0005739; GO:0006644; GO:0052642; GO:2001311 0 0 cd07061; PF00328; Q8BYM7 CHOYP_RSPH4A.1.1 m.15217 sp RSH4A_MOUSE 44.135 503 257 7 51 552 212 691 1.21E-121 378 RSH4A_MOUSE reviewed Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3) Rsph4a Rshl3 Mus musculus (Mouse) 716 axoneme assembly [GO:0035082]; cilium movement [GO:0003341] GO:0001534; GO:0003341; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005930; GO:0035082 0 0 0 PF04712; Q8C7R4 CHOYP_UBA6.2.4 m.50575 sp UBA6_MOUSE 50 206 74 2 1 177 32 237 1.21E-59 202 UBA6_MOUSE reviewed Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2) Uba6 Ube1l2 Mus musculus (Mouse) 1053 amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004839; GO:0005524; GO:0005737; GO:0005829; GO:0006511; GO:0007612; GO:0007626; GO:0016567; GO:0019780; GO:0021764; GO:0021766; GO:0042787; GO:0060996 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P22314}. 0 0 PF16191;PF16190;PF09358;PF00899;PF10585; Q8K2Z2 CHOYP_BRAFLDRAFT_117858.1.3 m.3827 sp PRP39_MOUSE 38.318 107 52 5 1 104 567 662 1.21E-09 57 PRP39_MOUSE reviewed Pre-mRNA-processing factor 39 (PRP39 homolog) Prpf39 Mus musculus (Mouse) 665 mRNA 5'-splice site recognition [GO:0000395] GO:0000243; GO:0000395; GO:0005685; GO:0071004 0 0 0 0 Q8K2Z2 CHOYP_BRAFLDRAFT_117858.3.3 m.61652 sp PRP39_MOUSE 38.318 107 52 5 1 104 567 662 1.21E-09 57 PRP39_MOUSE reviewed Pre-mRNA-processing factor 39 (PRP39 homolog) Prpf39 Mus musculus (Mouse) 665 mRNA 5'-splice site recognition [GO:0000395] GO:0000243; GO:0000395; GO:0005685; GO:0071004 0 0 0 0 Q8LGG8 CHOYP_LOC100185549.6.6 m.63147 sp USPAL_ARATH 25.49 153 95 4 4 138 8 159 1.21E-12 65.1 USPAL_ARATH reviewed Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) 175 response to stress [GO:0006950] GO:0005886; GO:0006950; GO:0016208 0 0 0 PF00582; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.16.34 m.36531 sp VWDE_HUMAN 24.315 292 207 5 686 965 800 1089 1.21E-15 86.7 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N567 CHOYP_ZCHC9.2.2 m.35925 sp ZCHC9_HUMAN 37.634 279 151 6 1 264 1 271 1.21E-53 177 ZCHC9_HUMAN reviewed Zinc finger CCHC domain-containing protein 9 ZCCHC9 Homo sapiens (Human) 271 "negative regulation of phosphatase activity [GO:0010923]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006351; GO:0008270; GO:0010923; GO:0044822 0 0 0 PF00098; Q8N8A2 CHOYP_LOC755521.11.28 m.39668 sp ANR44_HUMAN 36.22 254 161 1 1 253 152 405 1.21E-45 166 ANR44_HUMAN reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) 993 0 0 0 0 0 PF00023;PF12796; Q8NFD2 CHOYP_LOC755521.19.28 m.47703 sp ANKK1_HUMAN 40.23 174 104 0 14 187 378 551 1.21E-35 134 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8R151 CHOYP_ZNFX1.6.12 m.36997 sp ZNFX1_MOUSE 37.917 480 253 12 2 462 1042 1495 1.21E-84 287 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8TC92 CHOYP_ENOX2.1.1 m.7197 sp ENOX1_HUMAN 47.304 575 258 9 83 625 76 637 1.21E-163 486 ENOX1_HUMAN reviewed Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] ENOX1 PIG38 Homo sapiens (Human) 643 rhythmic process [GO:0048511] GO:0000166; GO:0003676; GO:0005615; GO:0005886; GO:0016491; GO:0048511 0 0 0 PF00076; Q8TCB7 CHOYP_METTL6.1.1 m.16056 sp METL6_HUMAN 63.846 260 91 2 65 323 12 269 1.21E-117 343 METL6_HUMAN reviewed Methyltransferase-like protein 6 (EC 2.1.1.-) METTL6 Homo sapiens (Human) 284 0 GO:0008168 0 0 0 PF08242; Q91WG7 CHOYP_DGKG.1.1 m.5679 sp DGKG_MOUSE 51.136 88 43 0 1 88 1 88 1.21E-22 97.8 DGKG_MOUSE reviewed Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (88 kDa diacylglycerol kinase) (Diglyceride kinase gamma) (DGK-gamma) Dgkg Dagk3 Mus musculus (Mouse) 788 intracellular signal transduction [GO:0035556]; neuron development [GO:0048666]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205] GO:0004143; GO:0005509; GO:0005524; GO:0005622; GO:0007205; GO:0035556; GO:0048666 0 0 0 PF00130;PF14513;PF00609;PF00781;PF13499; Q91YD4 CHOYP_TRPM2.7.12 m.45910 sp TRPM2_MOUSE 24.889 225 134 6 57 256 618 832 1.21E-12 71.6 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q99020 CHOYP_ROAA.2.6 m.26627 sp ROAA_MOUSE 55.422 166 73 1 53 218 70 234 1.21E-57 186 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q99020 CHOYP_ROAA.4.6 m.57564 sp ROAA_MOUSE 55.422 166 73 1 53 218 70 234 1.21E-57 186 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q99KR8 CHOYP_ISCW_ISCW003071.1.1 m.38510 sp FUCO2_MOUSE 57.292 192 77 3 2 191 158 346 1.21E-76 239 FUCO2_MOUSE reviewed Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) Fuca2 Mus musculus (Mouse) 461 fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617] GO:0004560; GO:0005615; GO:0006004; GO:0009617; GO:0016139; GO:0070062; GO:2000535 0 0 0 PF01120;PF16757; Q99M80 CHOYP_LOC578968.1.2 m.41294 sp PTPRT_MOUSE 34.596 396 238 8 109 493 770 1155 1.21E-59 223 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99NH0 CHOYP_LOC581927.16.27 m.39979 sp ANR17_MOUSE 36.803 269 161 7 3 264 387 653 1.21E-38 147 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9ET66 CHOYP_LOC494408.1.1 m.29208 sp PI16_MOUSE 41.279 172 90 5 130 300 29 190 1.21E-36 145 PI16_MOUSE reviewed Peptidase inhibitor 16 (PI-16) (Cysteine-rich protease inhibitor) Pi16 Cripi Mus musculus (Mouse) 489 negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052] GO:0005615; GO:0016021; GO:0030414; GO:0061052; GO:0070062 0 0 0 PF00188; Q9H0E3 CHOYP_LOC100370716.1.1 m.35654 sp SP130_HUMAN 35.793 271 151 8 710 964 781 1044 1.21E-46 185 SP130_HUMAN reviewed Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130) SAP130 Homo sapiens (Human) 1048 "histone H3 acetylation [GO:0043966]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003713; GO:0005654; GO:0006351; GO:0030914; GO:0043966; GO:0070822 0 0 0 PF16014; Q9H6E4 CHOYP_LOC101236441.2.2 m.61696 sp CC134_HUMAN 40.26 154 91 1 46 198 32 185 1.21E-38 136 CC134_HUMAN reviewed Coiled-coil domain-containing protein 134 CCDC134 Homo sapiens (Human) 229 0 GO:0005576; GO:0016020 0 0 0 PF15002; Q9HC56 CHOYP_PCDH9.3.5 m.54224 sp PCDH9_HUMAN 32.938 759 481 17 24 768 28 772 1.21E-103 358 PCDH9_HUMAN reviewed Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0030426; GO:0030900; GO:0044291 0 0 0 PF00028;PF08266;PF08374; Q9HCM2 CHOYP_PLXA2.3.3 m.52268 sp PLXA4_HUMAN 26.111 1957 1203 73 36 1858 47 1894 1.21E-158 538 PLXA4_HUMAN reviewed Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) 1894 anterior commissure morphogenesis [GO:0021960]; branchiomotor neuron axon guidance [GO:0021785]; chemorepulsion of branchiomotor axon [GO:0021793]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sympathetic nervous system development [GO:0048485]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644] GO:0002116; GO:0005886; GO:0005887; GO:0017154; GO:0021612; GO:0021615; GO:0021637; GO:0021644; GO:0021784; GO:0021785; GO:0021793; GO:0021960; GO:0030334; GO:0048485; GO:0048841; GO:0050923; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q9I925 CHOYP_BRAFLDRAFT_88228.1.1 m.51515 sp FUCL7_ANGJA 29.126 103 67 3 72 170 83 183 1.21E-06 49.7 FUCL7_ANGJA reviewed Fucolectin-7 0 Anguilla japonica (Japanese eel) 189 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9NUV9 CHOYP_GIMA4.5.7 m.51463 sp GIMA4_HUMAN 41.322 242 135 5 28 266 22 259 1.21E-48 168 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9QZK7 CHOYP_BRAFLDRAFT_87332.5.6 m.43958 sp DOK3_MOUSE 36.17 94 56 3 475 567 149 239 1.21E-09 64.3 DOK3_MOUSE reviewed Docking protein 3 (Downstream of tyrosine kinase 3) (p62(dok)-like protein) (DOK-L) Dok3 Dokl Mus musculus (Mouse) 444 Ras protein signal transduction [GO:0007265] GO:0005737; GO:0005886; GO:0007265 0 0 0 PF02174; Q9R0N9 CHOYP_NEMVEDRAFT_V1G79980.1.1 m.34351 sp SYT9_MOUSE 32.215 298 177 12 35 312 162 454 1.21E-28 120 SYT9_MOUSE reviewed Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V) Syt9 Syt5 Mus musculus (Mouse) 491 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of insulin secretion [GO:0050796]; vesicle fusion [GO:0006906] GO:0000149; GO:0001786; GO:0005509; GO:0005544; GO:0005546; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019905; GO:0030054; GO:0030276; GO:0030667; GO:0030672; GO:0031045; GO:0042802; GO:0045956; GO:0048791; GO:0050796; GO:0070382 0 0 0 PF00168; Q9R1R2 CHOYP_BRAFLDRAFT_88219.4.5 m.53356 sp TRIM3_MOUSE 24.324 259 174 10 259 504 482 731 1.21E-09 64.7 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U639 CHOYP_BRAFLDRAFT_114843.2.2 m.57237 sp HSP7D_MANSE 70.652 92 24 1 17 108 524 612 1.21E-38 141 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9UGM3 CHOYP_DMBT1.21.34 m.42760 sp DMBT1_HUMAN 41.456 632 267 13 1 534 166 792 1.21E-124 406 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9V477 CHOYP_PHUM_PHUM107160.1.1 m.50642 sp TOLL8_DROME 28.571 1246 753 32 3 1130 6 1232 1.21E-133 444 TOLL8_DROME reviewed Toll-like receptor Tollo (Toll-like receptor 8) Tollo Tl-8 Toll-8 CG6890 Drosophila melanogaster (Fruit fly) 1346 axis elongation [GO:0003401]; convergent extension [GO:0060026]; innate immune response in mucosa [GO:0002227]; peripheral nervous system neuron development [GO:0048935]; regulation of glucose metabolic process [GO:0010906]; regulation of protein glycosylation [GO:0060049]; signal transduction [GO:0007165] GO:0002227; GO:0003401; GO:0007165; GO:0010906; GO:0016021; GO:0016324; GO:0048935; GO:0060026; GO:0060049 0 0 0 PF13306;PF13855;PF01582; Q9VWK6 CHOYP_PGP2L.1.1 m.6854 sp PGP2L_DROME 41.6 250 135 3 3 244 56 302 1.21E-58 193 PGP2L_DROME reviewed Post-GPI attachment to proteins factor 2-like CG7990 Drosophila melanogaster (Fruit fly) 325 0 GO:0016021 0 0 0 PF10277; A2ASS6 CHOYP_LOC100367089.4.4 m.51961 sp TITIN_MOUSE 29.736 1288 803 31 1 1250 31434 32657 1.22E-133 457 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A2AX52 CHOYP_LOC100538183.1.2 m.42700 sp CO6A4_MOUSE 22.213 1211 759 38 40 1229 34 1082 1.22E-51 204 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A6QPC8 CHOYP_LOC100377759.10.15 m.45798 sp EID3_BOVIN 29.13 230 147 3 12 228 49 275 1.22E-18 92.4 EID3_BOVIN reviewed EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) EID3 Bos taurus (Bovine) 379 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005737; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0030915 0 0 0 PF15412;PF08743; B1AK53 CHOYP_ESPN.1.2 m.41467 sp ESPN_HUMAN 43.636 165 91 2 1 164 162 325 1.22E-37 140 ESPN_HUMAN reviewed Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein) ESPN DFNB36 LP2654 Homo sapiens (Human) 854 locomotory behavior [GO:0007626]; negative regulation of cytoskeleton organization [GO:0051494]; parallel actin filament bundle assembly [GO:0030046]; positive regulation of filopodium assembly [GO:0051491]; sensory perception of sound [GO:0007605] GO:0005737; GO:0005902; GO:0005903; GO:0007605; GO:0007626; GO:0017124; GO:0030046; GO:0031941; GO:0032426; GO:0051015; GO:0051491; GO:0051494 0 0 0 PF12796;PF02205; B1WAX6 CHOYP_NEMVEDRAFT_V1G242088.1.2 m.49445 sp TIGAR_XENTR 30.659 349 152 9 1 345 1 263 1.22E-39 144 TIGAR_XENTR reviewed "Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator)" tigar Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 275 "apoptotic process [GO:0006915]; autophagy [GO:0006914]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 2,6-bisphosphate metabolic process [GO:0006003]" GO:0004083; GO:0004331; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0006003; GO:0006914; GO:0006915; GO:0016791; GO:0030388 0 0 cd07067; PF00300; B5XAM2 CHOYP_CRNS1.1.1 m.65331 sp ICT1_SALSA 46.457 127 68 0 1 127 62 188 1.22E-33 119 ICT1_SALSA reviewed "Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (Immature colon carcinoma transcript 1 protein homolog)" ict1 Salmo salar (Atlantic salmon) 191 mitochondrial translational termination [GO:0070126] GO:0004045; GO:0005739; GO:0005762; GO:0016150; GO:0070126 0 0 0 PF00472; D3YXG0 CHOYP_HMCN2.7.12 m.37659 sp HMCN1_MOUSE 23.412 551 356 21 110 615 2598 3127 1.22E-21 104 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E2RYF8 CHOYP_TPX2.1.1 m.8645 sp TPX2_PATPE 34.49 893 485 23 8 816 11 887 1.22E-126 404 TPX2_PATPE reviewed Targeting protein for Xklp2 homolog (TPX2 homolog) (Microtubule-associated protein TPX2 homolog) TPX2 Patiria pectinifera (Starfish) (Asterina pectinifera) 891 activation of protein kinase activity [GO:0032147]; regulation of mitotic spindle organization [GO:0060236] GO:0005634; GO:0005737; GO:0005819; GO:0005874; GO:0032147; GO:0060236 0 0 0 PF06886;PF12214; F1LNI5 CHOYP_Y0417.2.2 m.29395 sp PPM1G_RAT 60.194 206 71 3 500 702 320 517 1.22E-72 248 PPM1G_RAT reviewed Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase magnesium-dependent 1 gamma) Ppm1g Rattus norvegicus (Rat) 542 cell cycle [GO:0007049] GO:0004722; GO:0005737; GO:0007049; GO:0016020; GO:0046872 0 0 0 PF00481; O62742 CHOYP_NEMVEDRAFT_V1G173950.1.1 m.13511 sp NLTP_RABIT 53.222 419 166 10 81 492 9 404 1.22E-144 429 NLTP_RABIT reviewed Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) SCP2 Oryctolagus cuniculus (Rabbit) 547 lipid transport [GO:0006869]; metabolic process [GO:0008152] GO:0005739; GO:0005777; GO:0006869; GO:0008152; GO:0008289; GO:0033814 0 0 0 PF02036;PF02803;PF00108; O70277 CHOYP_BRAFLDRAFT_79377.6.30 m.23953 sp TRIM3_RAT 26.4 125 86 3 71 192 622 743 1.22E-07 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_69764.12.19 m.33400 sp TRIM3_HUMAN 22.426 272 176 11 23 275 489 744 1.22E-10 65.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O94813 CHOYP_SLIT1.3.5 m.17442 sp SLIT2_HUMAN 35.193 233 135 4 21 252 496 713 1.22E-35 139 SLIT2_HUMAN reviewed Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) 1529 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; response to cortisol [GO:0051414]; response to nutrient levels [GO:0031667]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510]; ureteric bud development [GO:0001657] GO:0001657; GO:0001933; GO:0002042; GO:0002689; GO:0005095; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005737; GO:0005886; GO:0007411; GO:0008045; GO:0008201; GO:0009986; GO:0010593; GO:0010596; GO:0014912; GO:0016020; GO:0021510; GO:0021836; GO:0021972; GO:0030308; GO:0030336; GO:0030837; GO:0031290; GO:0031667; GO:0032870; GO:0035385; GO:0042802; GO:0042803; GO:0043065; GO:0043116; GO:0043237; GO:0043394; GO:0043395; GO:0048495; GO:0048754; GO:0048846; GO:0050728; GO:0050772; GO:0050919; GO:0050929; GO:0051058; GO:0051414; GO:0061364; GO:0070062; GO:0070100; GO:0071504; GO:0071672; GO:0071676; GO:0090024; GO:0090027; GO:0090260; GO:0090288 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; O97490 CHOYP_BRAFLDRAFT_124962.1.1 m.57433 sp TRFM_RABIT 32.653 735 423 24 26 736 23 709 1.22E-120 382 TRFM_RABIT reviewed Melanotransferrin (Membrane-bound transferrin-like protein p97) (CD antigen CD228) MELTF MFI2 Oryctolagus cuniculus (Rabbit) 736 ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] GO:0005615; GO:0005886; GO:0006811; GO:0031225; GO:0046872; GO:0055072 0 0 0 PF00405; P04179 CHOYP_SODM.2.2 m.62945 sp SODM_HUMAN 63.47 219 78 2 46 263 2 219 1.22E-101 298 SODM_HUMAN reviewed "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)" SOD2 Homo sapiens (Human) 222 age-dependent response to reactive oxygen species [GO:0001315]; negative regulation of cell proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; oxygen homeostasis [GO:0032364]; protein homotetramerization [GO:0051289]; regulation of blood pressure [GO:0008217]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; removal of superoxide radicals [GO:0019430]; response to reactive oxygen species [GO:0000302]; response to superoxide [GO:0000303]; superoxide metabolic process [GO:0006801]; vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [GO:0003069] GO:0000302; GO:0000303; GO:0001315; GO:0001836; GO:0003069; GO:0004784; GO:0005739; GO:0005759; GO:0006357; GO:0006801; GO:0008217; GO:0008285; GO:0019430; GO:0030145; GO:0032364; GO:0042802; GO:0043524; GO:0051289; GO:0070062; GO:1902176 0 0 0 PF02777;PF00081; P10394 CHOYP_YG31B.2.3 m.9009 sp POL4_DROME 27.691 1217 787 29 9 1179 57 1226 1.22E-129 433 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P15989 CHOYP_LOC101173335.1.4 m.945 sp CO6A3_CHICK 23.002 1952 1270 70 655 2547 38 1815 1.22E-108 395 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P17900 CHOYP_LOC100759507.1.1 m.30604 sp SAP3_HUMAN 36.747 166 96 4 74 230 26 191 1.22E-33 122 SAP3_HUMAN reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short] GM2A Homo sapiens (Human) 193 ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; positive regulation of hydrolase activity [GO:0051345] GO:0005319; GO:0005739; GO:0005889; GO:0006687; GO:0006689; GO:0007611; GO:0009313; GO:0009898; GO:0016004; GO:0019915; GO:0030290; GO:0032428; GO:0043202; GO:0045179; GO:0050885; GO:0051345; GO:0070062 0 0 0 PF02221; P18127 CHOYP_contig_027440 m.31157 sp ICEN_XANCT 37.918 269 137 6 3 246 298 561 1.22E-15 79.3 ICEN_XANCT reviewed Ice nucleation protein inaX Xanthomonas campestris pv. translucens 1567 0 GO:0009279; GO:0050825 0 0 0 PF00818; P19984 CHOYP_PROF1.2.2 m.36148 sp PROF2_ACACA 34.646 127 81 1 8 134 2 126 1.22E-23 91.7 PROF2_ACACA reviewed Profilin-2 (Basic profilin) (Profilin II) 0 Acanthamoeba castellanii (Amoeba) 126 0 GO:0005737; GO:0005856 0 0 0 PF00235; P22856 CHOYP_BRAFLDRAFT_90042.2.2 m.59014 sp VL96_IRV1 26.974 152 96 3 156 298 600 745 1.22E-10 68.2 VL96_IRV1 reviewed Putative ubiquitin thioesterase L96 (EC 3.4.19.12) L96 Tipula iridescent virus (TIV) (Insect iridescent virus type 1) 867 "DNA-templated transcription, termination [GO:0006353]; viral release from host cell [GO:0019076]" GO:0003677; GO:0006353; GO:0019076; GO:0036459 0 0 0 PF02338; P23913 CHOYP_LOC581447.1.1 m.65782 sp LBR_CHICK 47.976 494 244 6 505 992 115 601 1.22E-153 472 LBR_CHICK reviewed Lamin-B receptor LBR Gallus gallus (Chicken) 637 sterol biosynthetic process [GO:0016126] GO:0003677; GO:0005639; GO:0016126; GO:0016627; GO:0016628 0 0 0 PF01222;PF09465; P28285 CHOYP_LOC100145215.1.1 m.6904 sp 5HT2A_DROME 57.647 85 36 0 131 215 736 820 1.22E-28 116 5HT2A_DROME reviewed 5-hydroxytryptamine receptor 2A (5-HT receptor 2A) (Serotonin receptor 2A) 5-HT1A 5HT-R2A CG16720 Drosophila melanogaster (Fruit fly) 834 "adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; anesthesia-resistant memory [GO:0007615]; inter-male aggressive behavior [GO:0002121]; male courtship behavior [GO:0008049]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; serotonin receptor signaling pathway [GO:0007210]" GO:0001586; GO:0002121; GO:0004993; GO:0005886; GO:0007198; GO:0007208; GO:0007210; GO:0007615; GO:0008049; GO:0008227; GO:0016021; GO:0045187 0 0 0 PF00001; P37167 CHOYP_ACTP.2.2 m.22086 sp ACTP_ACACA 29.286 140 93 3 3 142 2 135 1.22E-11 61.2 ACTP_ACACA reviewed Actophorin 0 Acanthamoeba castellanii (Amoeba) 138 actin filament depolymerization [GO:0030042] GO:0005737; GO:0015629; GO:0030042 0 0 cd11286; PF00241; P38529 CHOYP_HSF1.2.2 m.38636 sp HSF1_CHICK 54.244 271 98 9 6 262 20 278 1.22E-87 279 HSF1_CHICK reviewed Heat shock factor protein 1 (HSF 1) (HSF 3A) (HSTF 3A) (Heat shock transcription factor 1) (HSTF 1) HSF1 Gallus gallus (Chicken) 491 "cellular response to heat [GO:0034605]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of cell cycle G2/M phase transition [GO:1902751]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; protein homotrimerization [GO:0070207]; response to heat [GO:0009408]; response to light stimulus [GO:0009416]; transcription, DNA-templated [GO:0006351]" GO:0001046; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0008284; GO:0009408; GO:0009416; GO:0010628; GO:0034605; GO:0042803; GO:0043565; GO:0070207; GO:1902751; GO:1902808 0 0 0 PF00447;PF06546; P41937 CHOYP_TBB2.2.2 m.53001 sp TBB4_CAEEL 85.849 212 30 0 1 212 233 444 1.22E-130 377 TBB4_CAEEL reviewed Tubulin beta-4 chain (Beta-4-tubulin) tbb-4 B0272.1 Caenorhabditis elegans 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005879; GO:0007017 0 0 0 PF00091;PF03953; P49395 CHOYP_RS3A.4.15 m.15367 sp RS3A_APLCA 81.509 265 46 1 1 262 1 265 1.22E-153 431 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P50174 CHOYP_BRAFLDRAFT_109688.1.1 m.59704 sp THIL_RHIME 61.559 372 141 1 118 489 17 386 1.22E-163 471 THIL_RHIME reviewed Acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) phbA R03262 SMc03879 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) 393 poly-hydroxybutyrate biosynthetic process [GO:0042619] GO:0003985; GO:0005737; GO:0042619 PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3. 0 0 PF02803;PF00108; P54357 CHOYP_LOC100881900.2.3 m.25739 sp MLC2_DROME 63.265 147 54 0 39 185 1 147 1.22E-65 201 MLC2_DROME reviewed Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain) Mlc-c CG3201 Drosophila melanogaster (Fruit fly) 147 actin filament-based movement [GO:0030048] GO:0005509; GO:0016459; GO:0016460; GO:0017022; GO:0030048; GO:0031475; GO:0031476; GO:0031477; GO:0032036 0 0 0 PF13405;PF13499; P86954 CHOYP_ELDP2.2.2 m.40194 sp ELDP2_PINMA 37.047 359 214 6 7 363 9 357 1.22E-74 238 ELDP2_PINMA reviewed EGF-like domain-containing protein 2 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 357 0 GO:0005576 0 0 0 0 P98174 CHOYP_FGD1.1.2 m.11030 sp FGD1_HUMAN 41.746 527 277 10 291 792 397 918 1.22E-123 398 FGD1_HUMAN reviewed "FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)" FGD1 FGDY ZFYVE3 Homo sapiens (Human) 961 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; multicellular organism development [GO:0007275]; organ morphogenesis [GO:0009887]; positive regulation of apoptotic process [GO:0043065]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0001726; GO:0005085; GO:0005089; GO:0005737; GO:0005794; GO:0005829; GO:0005856; GO:0007010; GO:0007165; GO:0007275; GO:0008360; GO:0009887; GO:0030027; GO:0030036; GO:0031267; GO:0035023; GO:0043065; GO:0043087; GO:0046847; GO:0046872; GO:0051056 0 0 0 PF01363;PF00169;PF00621; P9WK87 CHOYP_LOC100371983.1.3 m.2863 sp NLHH_MYCTU 34.286 245 148 5 85 320 54 294 1.22E-33 129 NLHH_MYCTU reviewed Carboxylesterase NlhH (EC 3.1.1.1) nlhH lipH Rv1399c Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 319 catabolic process [GO:0009056] GO:0009056; GO:0034338 0 0 0 PF07859; Q08BY0 CHOYP_LOC101171379.1.1 m.27459 sp NDUF7_DANRE 48.787 371 179 4 66 428 26 393 1.22E-128 382 NDUF7_DANRE reviewed "NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 (Protein midA homolog, mitochondrial)" ndufaf7 zgc:153989 Danio rerio (Zebrafish) (Brachydanio rerio) 422 ATP metabolic process [GO:0046034]; chordate embryonic development [GO:0043009]; mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005739; GO:0032981; GO:0043009; GO:0046034 0 0 0 PF02636; Q0VGY8 CHOYP_AAEL_AAEL014742.4.8 m.42724 sp TANC1_MOUSE 43.158 95 54 0 5 99 1093 1187 1.22E-19 85.9 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q10982 CHOYP_LOC100493351.1.1 m.27714 sp FUT2_PIG 26.623 308 195 12 122 412 37 330 1.22E-24 107 FUT2_PIG reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Sus scrofa (Pig) 340 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q14159 CHOYP_LOC100374845.1.1 m.49323 sp SPIDR_HUMAN 33.544 158 81 6 203 343 235 385 1.22E-08 61.2 SPIDR_HUMAN reviewed DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) SPIDR KIAA0146 Homo sapiens (Human) 915 cellular response to camptothecin [GO:0072757]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein complex assembly [GO:0031334]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of establishment of protein localization to chromosome [GO:0070202] GO:0000228; GO:0000724; GO:0005654; GO:0006974; GO:0010569; GO:0031334; GO:0070202; GO:0071479; GO:0072711; GO:0072757; GO:2000781 0 0 0 PF14950;PF14951; Q14162 CHOYP_BM1_57400.7.7 m.66931 sp SREC_HUMAN 30.588 340 170 13 5 322 120 415 1.22E-21 101 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q14CM0 CHOYP_BRAFLDRAFT_63883.1.1 m.27320 sp FRPD4_HUMAN 44.834 571 295 12 35 600 14 569 1.22E-146 489 FRPD4_HUMAN reviewed FERM and PDZ domain-containing protein 4 (PDZ domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso) FRMPD4 KIAA0316 PDZD10 PDZK10 Homo sapiens (Human) 1322 positive regulation of synapse structural plasticity [GO:0051835] GO:0005546; GO:0005856; GO:0043197; GO:0051835 0 0 0 PF00373;PF00595; Q16629 CHOYP_SRSF7.1.1 m.40146 sp SRSF7_HUMAN 52.055 73 33 1 13 85 12 82 1.22E-15 78.2 SRSF7_HUMAN reviewed "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) 238 "mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000166; GO:0000398; GO:0005634; GO:0005654; GO:0005737; GO:0006369; GO:0006397; GO:0006405; GO:0006406; GO:0008270; GO:0008380; GO:0031124; GO:0044822; GO:0048025; GO:0070062 0 0 0 PF00076; Q1MSJ5 CHOYP_CSPP1.12.14 m.54551 sp CSPP1_HUMAN 30.25 1200 567 45 531 1604 170 1225 1.22E-54 213 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q24372 CHOYP_SMP_174040.2.3 m.48757 sp LACH_DROME 31.93 285 166 8 82 360 59 321 1.22E-33 131 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q28619 CHOYP_ISCW_ISCW003477.1.1 m.37800 sp NHRF1_RABIT 37.681 345 134 7 6 350 12 275 1.22E-60 203 NHRF1_RABIT reviewed Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) SLC9A3R1 NHERF NHERF1 Oryctolagus cuniculus (Rabbit) 358 bile acid secretion [GO:0032782]; glutathione transport [GO:0034635]; negative regulation of cell motility [GO:2000146]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein kinase B signaling [GO:0051898]; regulation of protein kinase activity [GO:0045859]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; Wnt signaling pathway [GO:0016055] GO:0001726; GO:0005737; GO:0005902; GO:0010642; GO:0012505; GO:0014067; GO:0016020; GO:0016055; GO:0016324; GO:0017081; GO:0030175; GO:0031528; GO:0032782; GO:0034635; GO:0045859; GO:0051898; GO:0070293; GO:0071944; GO:0097225; GO:0097291; GO:2000146 0 0 0 PF09007;PF00595; Q2T9K2 CHOYP_PHUM_PHUM549810.1.1 m.11967 sp AP2E_XENLA 71.889 217 59 1 189 405 199 413 1.22E-106 324 AP2E_XENLA reviewed Transcription factor AP-2-epsilon (AP-2-epsilon) tfap2e Xenopus laevis (African clawed frog) 434 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351 0 0 0 PF03299; Q2T9W3 CHOYP_LOC591570.1.1 m.4767 sp CCD63_BOVIN 35.175 543 334 7 32 562 1 537 1.22E-80 266 CCD63_BOVIN reviewed Coiled-coil domain-containing protein 63 CCDC63 Bos taurus (Bovine) 558 spermatid development [GO:0007286] GO:0007286 0 0 0 0 Q32KU3 CHOYP_LOC100366738.1.1 m.63810 sp MORN2_BOVIN 56.338 71 31 0 79 149 1 71 1.22E-21 85.5 MORN2_BOVIN reviewed MORN repeat-containing protein 2 MORN2 Bos taurus (Bovine) 79 0 0 0 0 0 PF02493; Q3USF0 CHOYP_B3GN5.3.4 m.59075 sp B3GN6_MOUSE 31.466 232 147 3 81 302 95 324 1.22E-37 142 B3GN6_MOUSE reviewed "Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.147) (Core 3 synthase) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6) (BGnT-6) (Beta-1,3-Gn-T6) (Beta-1,3-N-acetylglucosaminyltransferase 6) (Beta3Gn-T6)" B3gnt6 Mus musculus (Mouse) 391 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021; GO:0047224 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q4UMH6 CHOYP_LATA.1.1 m.55048 sp Y381_RICFE 26.198 313 209 8 583 892 799 1092 1.22E-21 105 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q4ZJM9 CHOYP_LOC100561667.3.4 m.43712 sp C1QL4_MOUSE 35.897 117 65 5 67 179 123 233 1.22E-09 58.9 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q502M6 CHOYP_TVAG_388180.1.8 m.3900 sp ANR29_DANRE 36.364 187 119 0 13 199 43 229 1.22E-32 122 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5BIM1 CHOYP_TRI33.5.8 m.56888 sp TRI45_BOVIN 23.03 330 209 11 3 301 18 333 1.22E-12 74.7 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5EA79 CHOYP_BRAFLDRAFT_284587.2.3 m.15867 sp GALM_BOVIN 37.574 338 198 8 11 342 9 339 1.22E-74 236 GALM_BOVIN reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM Bos taurus (Bovine) 342 galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006] GO:0004034; GO:0005737; GO:0006006; GO:0006012; GO:0030246; GO:0070062 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; Q5RF32 CHOYP_BRAFLDRAFT_90098.4.4 m.28113 sp BHMT2_PONAB 34.132 334 195 9 2 329 9 323 1.22E-55 188 BHMT2_PONAB reviewed S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 363 methionine biosynthetic process [GO:0009086] GO:0005737; GO:0008270; GO:0009086; GO:0047150 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. 0 0 PF02574; Q5RKJ1 CHOYP_LOC100373339.1.1 m.5653 sp MAEA_RAT 61.24 387 145 3 18 403 14 396 1.22E-171 488 MAEA_RAT reviewed Macrophage erythroblast attacher Maea Rattus norvegicus (Rat) 396 cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoskeleton organization [GO:0007010]; enucleate erythrocyte development [GO:0048822]; erythrocyte maturation [GO:0043249]; negative regulation of myeloid cell apoptotic process [GO:0033033] GO:0005819; GO:0005826; GO:0005887; GO:0007010; GO:0007049; GO:0007155; GO:0016363; GO:0033033; GO:0043249; GO:0048822; GO:0051301 0 0 0 PF10607; Q5VU97 CHOYP_CAHD1.3.6 m.39581 sp CAHD1_HUMAN 30.021 483 314 15 3 468 588 1063 1.22E-54 203 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6NU91 CHOYP_NOC41.1.1 m.53790 sp NOC4B_XENLA 45.175 487 259 5 26 505 32 517 1.22E-143 426 NOC4B_XENLA reviewed Nucleolar complex protein 4 homolog B (NOC4 protein homolog B) (NOC4-like protein B) (Nucleolar complex-associated protein 4-like protein B) noc4l-b Xenopus laevis (African clawed frog) 525 ribosome biogenesis [GO:0042254] GO:0005730; GO:0016021; GO:0031965; GO:0042254 0 0 0 PF03914; Q6P877 CHOYP_LOC100374268.1.1 m.58983 sp ADRM1_XENTR 55.699 386 151 8 19 389 1 381 1.22E-124 369 ADRM1_XENTR reviewed Proteasomal ubiquitin receptor ADRM1 adrm1 TEgg050m05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 404 proteasome assembly [GO:0043248] GO:0000502; GO:0005634; GO:0005737; GO:0043248; GO:0061133 0 0 0 PF04683;PF16550; Q6TGU2 CHOYP_SEH1.1.1 m.55025 sp SEH1_DANRE 65.487 339 108 4 1 336 1 333 1.22E-164 467 SEH1_DANRE reviewed Nucleoporin seh1 (Nup107-160 subcomplex subunit seh1) seh1l sec13l si:dkey-263o22.4 Danio rerio (Zebrafish) (Brachydanio rerio) 364 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; mitotic metaphase plate congression [GO:0007080]; mRNA transport [GO:0051028]; nuclear pore organization [GO:0006999]; protein transport [GO:0015031] GO:0000777; GO:0006999; GO:0007080; GO:0015031; GO:0031080; GO:0051028; GO:0051301; GO:0051315 0 0 0 PF00400; Q7TN88 CHOYP_REJ6.2.4 m.35988 sp PK1L2_MOUSE 30.769 338 207 8 470 803 1314 1628 1.22E-36 155 PK1L2_MOUSE reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) 2461 detection of mechanical stimulus [GO:0050982] GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q7ZZ00 CHOYP_LOC100691787.1.1 m.15936 sp ZN511_DANRE 42.64 197 79 5 47 212 84 277 1.22E-48 164 ZN511_DANRE reviewed Zinc finger protein 511 znf511 Danio rerio (Zebrafish) (Brachydanio rerio) 277 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q86WI1 CHOYP_PKHL1.2.3 m.26330 sp PKHL1_HUMAN 37.713 647 372 13 247 877 18 649 1.22E-112 384 PKHL1_HUMAN reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) 4243 immune response [GO:0006955] GO:0004872; GO:0005615; GO:0005829; GO:0006955; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8BZ39 CHOYP_BRAFLDRAFT_208548.1.1 m.44120 sp NMUR2_MOUSE 23.396 265 175 7 37 281 32 288 1.22E-12 72.8 NMUR2_MOUSE reviewed Neuromedin-U receptor 2 (NMU-R2) Nmur2 Mus musculus (Mouse) 395 activation of phospholipase A2 activity by calcium-mediated signaling [GO:0043006]; arachidonic acid secretion [GO:0050482]; calcium ion transport [GO:0006816]; central nervous system development [GO:0007417]; grooming behavior [GO:0007625]; inositol phosphate-mediated signaling [GO:0048016]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; reduction of food intake in response to dietary excess [GO:0002023]; response to pain [GO:0048265] GO:0001607; GO:0002023; GO:0005229; GO:0005525; GO:0005829; GO:0005886; GO:0006816; GO:0007200; GO:0007204; GO:0007218; GO:0007417; GO:0007625; GO:0008188; GO:0016021; GO:0042924; GO:0043006; GO:0048016; GO:0048265; GO:0050482 0 0 0 PF00001; Q8N5D0 CHOYP_ISCW_ISCW007151.2.2 m.41980 sp WDTC1_HUMAN 45.977 522 239 7 8 529 10 488 1.22E-153 459 WDTC1_HUMAN reviewed WD and tetratricopeptide repeats protein 1 WDTC1 KIAA1037 Homo sapiens (Human) 677 cellular chemical homeostasis [GO:0055082]; cellular response to insulin stimulus [GO:0032869]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of cell size [GO:0008361] GO:0000122; GO:0001701; GO:0004857; GO:0005634; GO:0005829; GO:0006006; GO:0008361; GO:0016567; GO:0032869; GO:0035264; GO:0045717; GO:0055082 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q8Q0U0 CHOYP_Y220.6.6 m.61152 sp Y045_METMA 36.145 166 97 2 795 960 175 331 1.22E-21 101 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q8TD43 CHOYP_TRPM4.1.2 m.6134 sp TRPM4_HUMAN 23.75 400 257 12 1 369 72 454 1.22E-21 102 TRPM4_HUMAN reviewed Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) TRPM4 LTRPC4 Homo sapiens (Human) 1214 adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; cardiac conduction [GO:0061337]; dendritic cell chemotaxis [GO:0002407]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of atrial cardiac muscle cell action potential [GO:1903949]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of regulation of vascular smooth muscle cell membrane depolarization [GO:1904199]; positive regulation of vasoconstriction [GO:0045907]; protein sumoylation [GO:0016925]; regulation of T cell cytokine production [GO:0002724]; vasoconstriction [GO:0042310] GO:0002250; GO:0002407; GO:0002724; GO:0005227; GO:0005262; GO:0005272; GO:0005524; GO:0005654; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0007204; GO:0008284; GO:0010460; GO:0016021; GO:0016925; GO:0030502; GO:0035774; GO:0042310; GO:0043025; GO:0045600; GO:0045668; GO:0045907; GO:0061337; GO:0070588; GO:0090263; GO:1903949; GO:1904179; GO:1904199 0 0 0 PF00520; Q8VI56 CHOYP_LOC100890082.1.1 m.287 sp LRP4_MOUSE 38.65 163 91 5 2 161 1192 1348 1.22E-27 112 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q8ZNY9 CHOYP_LOC101243356.1.1 m.7906 sp PRP1_SALTY 26.577 222 136 6 68 280 12 215 1.22E-14 74.7 PRP1_SALTY reviewed Serine/threonine-protein phosphatase 1 (EC 3.1.3.16) pphA prpA STM1853 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 216 0 GO:0004721; GO:0046872 0 0 0 PF00149; Q90773 CHOYP_LOC663736.1.2 m.3404 sp CEPU1_CHICK 29.586 338 187 10 9 343 21 310 1.22E-28 118 CEPU1_CHICK reviewed Protein CEPU-1 0 Gallus gallus (Chicken) 353 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225 0 0 0 PF07679;PF00047; Q91604 CHOYP_STK11.1.1 m.19137 sp STK11_XENLA 58.105 401 147 4 39 418 29 429 1.22E-157 454 STK11_XENLA reviewed Serine/threonine-protein kinase stk11 (EC 2.7.11.1) (Liver kinase B1 homolog) (lkb1) (Serine/threonine-protein kinase XEEK1) stk11 eek1 Xenopus laevis (African clawed frog) 432 cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; establishment of cell polarity [GO:0030010]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell growth [GO:0030308]; protein autophosphorylation [GO:0046777]; regulation of cell growth [GO:0001558]; response to ionizing radiation [GO:0010212]; vasculature development [GO:0001944] GO:0001558; GO:0001944; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006974; GO:0007049; GO:0010212; GO:0016020; GO:0030010; GO:0030295; GO:0030308; GO:0042593; GO:0046777; GO:0046872; GO:0072332 0 0 0 PF00069; Q95SX7 CHOYP_LOC100892567.8.8 m.57017 sp RTBS_DROME 29.263 434 273 8 13 422 476 899 1.22E-47 179 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q96RW7 CHOYP_BRAFLDRAFT_205939.3.3 m.64021 sp HMCN1_HUMAN 36.585 205 88 10 4 171 5121 5320 1.22E-26 108 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BQ16 CHOYP_BRAFLDRAFT_122807.1.1 m.3730 sp TICN3_HUMAN 48.333 60 29 1 31 88 316 375 1.22E-09 58.9 TICN3_HUMAN reviewed "Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)" SPOCK3 TICN3 UNQ409/PRO771 Homo sapiens (Human) 436 negative regulation of endopeptidase activity [GO:0010951]; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan [GO:0019800]; signal transduction [GO:0007165] GO:0005509; GO:0005539; GO:0005578; GO:0005615; GO:0007165; GO:0008191; GO:0010951; GO:0019800; GO:0031012 0 0 0 PF07648;PF10591;PF00086; Q9BRU9 CHOYP_ISCW_ISCW011295.1.1 m.10240 sp UTP23_HUMAN 39.64 222 119 4 1 213 1 216 1.22E-45 155 UTP23_HUMAN reviewed rRNA-processing protein UTP23 homolog UTP23 C8orf53 Homo sapiens (Human) 249 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" GO:0000462; GO:0005730; GO:0032040; GO:0044822; GO:0070181 0 0 0 PF04900; Q9CRB6 CHOYP_LOC559490.1.1 m.44696 sp TPPP3_MOUSE 41.765 170 86 6 9 172 6 168 1.22E-25 100 TPPP3_MOUSE reviewed Tubulin polymerization-promoting protein family member 3 Tppp3 Mus musculus (Mouse) 176 microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785] GO:0001578; GO:0005737; GO:0005874; GO:0015631; GO:0046785; GO:0070062 0 0 0 PF05517; Q9CXK4 CHOYP_RCOM_1504880.1.1 m.43852 sp SWET1_MOUSE 25.414 181 135 0 31 211 35 215 1.22E-13 70.5 SWET1_MOUSE reviewed Sugar transporter SWEET1 (MmSWEET1) (RAG1-activating protein 1) (Solute carrier family 50 member 1) Slc50a1 Rag1ap1 Rga Mus musculus (Mouse) 221 "carbohydrate transport [GO:0008643]; positive regulation of gene expression, epigenetic [GO:0045815]" GO:0000139; GO:0005634; GO:0005794; GO:0005886; GO:0008643; GO:0016021; GO:0042947; GO:0045815; GO:0051119 0 0 0 PF03083; Q9D1C2 CHOYP_BRAFLDRAFT_59498.2.2 m.31183 sp CBY1_MOUSE 55.039 129 54 3 11 137 1 127 1.22E-39 132 CBY1_MOUSE reviewed "Protein chibby homolog 1 (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)" Cby1 Cby Pgea1 Mus musculus (Mouse) 127 "cardiac muscle cell differentiation [GO:0055007]; cilium assembly [GO:0042384]; fat cell differentiation [GO:0045444]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; protein localization [GO:0008104]" GO:0005634; GO:0005802; GO:0008013; GO:0008104; GO:0016607; GO:0030178; GO:0036064; GO:0042384; GO:0042802; GO:0045444; GO:0045892; GO:0055007; GO:0090090 0 0 0 PF14645; Q9DG68 CHOYP_RLA0.1.7 m.4365 sp RLA0_RANSY 73.822 191 50 0 1 191 1 191 1.22E-98 291 RLA0_RANSY reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) 315 ribosome biogenesis [GO:0042254] GO:0005840; GO:0042254 0 0 0 PF00466; Q9ESN6 CHOYP_ZF_BBOX_RING_-1.5.10 m.34434 sp TRIM2_MOUSE 26.484 219 142 7 345 554 536 744 1.22E-10 67.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H8L6 CHOYP_LOC100698649.8.8 m.59725 sp MMRN2_HUMAN 32.231 121 78 2 82 202 814 930 1.22E-09 61.2 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; Q9JKW0 CHOYP_ARL6IP1.1.1 m.13877 sp AR6P1_MOUSE 34.673 199 124 2 9 201 3 201 1.22E-41 142 AR6P1_MOUSE reviewed ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Protein TBX2) Arl6ip1 Arl6ip Mus musculus (Mouse) 203 apoptotic process [GO:0006915]; cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum tubular network assembly [GO:0071787]; endoplasmic reticulum tubular network membrane organization [GO:1990809]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of L-glutamate transport [GO:0002038] GO:0002038; GO:0005737; GO:0005783; GO:0005784; GO:0005789; GO:0005829; GO:0006613; GO:0006915; GO:0016020; GO:0016021; GO:0030176; GO:0043066; GO:0043154; GO:0071787; GO:1990809 0 0 0 0 Q9N2N6 CHOYP_LOC101061694.1.1 m.49902 sp TBB_EUPFO 61.905 147 38 3 1 139 1 137 1.22E-50 171 TBB_EUPFO reviewed Tubulin beta chain (Beta-tubulin) 0 Euplotes focardii 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q9NYY3 CHOYP_LOC584420.1.1 m.22182 sp PLK2_HUMAN 42.414 613 335 6 59 657 72 680 1.22E-175 519 PLK2_HUMAN reviewed Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase) PLK2 SNK Homo sapiens (Human) 685 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; long term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitotic cell cycle checkpoint [GO:0007093]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of dendritic spine development [GO:0061000]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of autophagy [GO:0010508]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of centriole replication [GO:0046599]; regulation of synaptic plasticity [GO:0048167]" GO:0000082; GO:0000785; GO:0004674; GO:0004871; GO:0005524; GO:0005622; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0006468; GO:0006977; GO:0007052; GO:0007093; GO:0007265; GO:0007613; GO:0010508; GO:0018105; GO:0030425; GO:0032092; GO:0032436; GO:0032486; GO:0043008; GO:0043066; GO:0043123; GO:0045732; GO:0046599; GO:0048167; GO:0060291; GO:0060292; GO:0061000 0 0 cd13118;cd13117; PF00069;PF00659; Q9QXW2 CHOYP_ISCW_ISCW008293.3.5 m.49173 sp FBXW5_MOUSE 30 220 145 7 13 228 9 223 1.22E-14 79.7 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9R1R2 CHOYP_BRAFLDRAFT_205965.18.43 m.39271 sp TRIM3_MOUSE 25 152 109 3 89 236 593 743 1.22E-06 53.1 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9V0D5 CHOYP_LOC101069440.3.3 m.28439 sp MDH_PYRAB 40.39 359 194 11 9 357 14 362 1.22E-69 225 MDH_PYRAB reviewed Malate dehydrogenase (EC 1.1.1.37) mdh PYRAB08550 PAB1791 Pyrococcus abyssi (strain GE5 / Orsay) 362 tricarboxylic acid cycle [GO:0006099] GO:0005737; GO:0006099; GO:0030060 0 0 0 PF02615; Q9Y493 CHOYP_SSPO.12.14 m.53188 sp ZAN_HUMAN 26.692 517 297 16 1695 2165 1074 1554 1.22E-43 180 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A0A0R4IBK5 CHOYP_NEMVEDRAFT_V1G199550.1.1 m.20816 sp R213A_DANRE 24.449 1497 918 56 495 1859 206 1621 1.23E-70 268 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A2ASS6 CHOYP_TITIN.17.19 m.63795 sp TITIN_MOUSE 28.708 209 132 9 142 333 19085 19293 1.23E-08 62 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A2AX52 CHOYP_BRAFLDRAFT_234820.1.1 m.63188 sp CO6A4_MOUSE 30.916 262 170 4 17 270 224 482 1.23E-35 138 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A2RU67 CHOYP_LOC100634454.1.1 m.11720 sp F234B_HUMAN 25.379 528 301 21 11 519 53 506 1.23E-28 125 F234B_HUMAN reviewed Protein FAM234B FAM234B KIAA1467 Homo sapiens (Human) 622 0 GO:0016021 0 0 0 0 A4IF63 CHOYP_BRAFLDRAFT_88217.3.14 m.13240 sp TRIM2_BOVIN 25.517 145 103 3 404 544 600 743 1.23E-07 58.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; C8BKC7 CHOYP_MYD88.1.7 m.1624 sp MYD88_SHEEP 26.498 317 193 6 26 339 16 295 1.23E-21 99.4 MYD88_SHEEP reviewed Myeloid differentiation primary response protein MyD88 MYD88 Ovis aries (Sheep) 296 defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0002755; GO:0005737; GO:0006954; GO:0043123; GO:0045087; GO:0050830 0 0 0 PF00531;PF01582; D9IQ16 CHOYP_LOC100892964.1.2 m.25532 sp GXN_ACRMI 26.295 251 146 11 34 273 48 270 1.23E-13 75.1 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 O14522 CHOYP_PTPRT.5.45 m.18594 sp PTPRT_HUMAN 33.264 481 283 10 5 461 925 1391 1.23E-73 255 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O18823 CHOYP_MONBRDRAFT_34989.1.1 m.34385 sp AOAH_RABIT 43.303 545 289 8 40 573 40 575 1.23E-168 494 AOAH_RABIT reviewed Acyloxyacyl hydrolase (EC 3.1.1.77) [Cleaved into: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit] AOAH Oryctolagus cuniculus (Rabbit) 575 lipopolysaccharide metabolic process [GO:0008653]; negative regulation of inflammatory response [GO:0050728] GO:0005576; GO:0008653; GO:0050528; GO:0050728 0 0 0 PF00657;PF03489; O43251 CHOYP_RFOX2.1.2 m.24118 sp RFOX2_HUMAN 43.885 278 121 9 45 314 21 271 1.23E-48 172 RFOX2_HUMAN reviewed RNA binding protein fox-1 homolog 2 (Fox-1 homolog B) (Hexaribonucleotide-binding protein 2) (RNA-binding motif protein 9) (RNA-binding protein 9) (Repressor of tamoxifen transcriptional activity) RBFOX2 FOX2 HRNBP2 RBM9 RTA Homo sapiens (Human) 390 "dendrite morphogenesis [GO:0048813]; fibroblast growth factor receptor signaling pathway [GO:0008543]; intracellular estrogen receptor signaling pathway [GO:0030520]; mRNA processing [GO:0006397]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; neuromuscular process controlling balance [GO:0050885]; radial glia guided migration of Purkinje cell [GO:0021942]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell proliferation [GO:0042127]; regulation of definitive erythrocyte differentiation [GO:0010724]; RNA metabolic process [GO:0016070]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003714; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005737; GO:0006397; GO:0007399; GO:0008134; GO:0008380; GO:0008543; GO:0010724; GO:0016070; GO:0021942; GO:0030520; GO:0042127; GO:0044822; GO:0045892; GO:0048813; GO:0050885 0 0 0 PF12414;PF00076; O43301 CHOYP_BRAFLDRAFT_208436.7.32 m.35151 sp HS12A_HUMAN 30.671 626 373 11 5 578 51 667 1.23E-91 299 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O73888 CHOYP_GSTS8.1.1 m.12434 sp HPGDS_CHICK 51.648 91 44 0 21 111 1 91 1.23E-30 110 HPGDS_CHICK reviewed Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) HPGDS GSTS PGDS PTGDS2 Gallus gallus (Chicken) 199 negative regulation of male germ cell proliferation [GO:2000255]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin metabolic process [GO:0006693] GO:0000287; GO:0001516; GO:0004364; GO:0004667; GO:0005509; GO:0005737; GO:0006693; GO:2000255 0 0 0 PF14497;PF02798; O75382 CHOYP_BRAFLDRAFT_87269.1.8 m.21263 sp TRIM3_HUMAN 25.581 258 174 9 221 465 492 744 1.23E-12 73.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O86034 CHOYP_TMO_0856.3.3 m.59922 sp BDHA_RHIME 37.795 254 155 2 28 278 3 256 1.23E-47 162 BDHA_RHIME reviewed D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) bdhA RB1136 SMb21010 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) 258 0 GO:0003858 0 0 0 0 O95714 CHOYP_RL17.3.7 m.36828 sp HERC2_HUMAN 34.286 175 92 2 9 183 8 159 1.23E-25 106 HERC2_HUMAN reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; intracellular protein transport [GO:0006886]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005743; GO:0005814; GO:0006303; GO:0006886; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016925; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; P05709 CHOYP_LOC100891430.1.1 m.60737 sp SIM_DROME 31.937 382 215 8 41 401 27 384 1.23E-55 208 SIM_DROME reviewed Protein single-minded sim CG7771 Drosophila melanogaster (Fruit fly) 697 "adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; brain development [GO:0007420]; determination of genital disc primordium [GO:0035225]; ectoderm development [GO:0007398]; locomotion [GO:0040011]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]; ventral cord development [GO:0007419]; ventral midline development [GO:0007418]" GO:0000978; GO:0000982; GO:0005634; GO:0005667; GO:0005737; GO:0006355; GO:0006366; GO:0007398; GO:0007409; GO:0007411; GO:0007418; GO:0007419; GO:0007420; GO:0007628; GO:0035225; GO:0040011; GO:0043565; GO:0045944; GO:0046982 0 0 0 PF00010;PF00989;PF08447; P06731 CHOYP_CADM3.3.4 m.42911 sp CEAM5_HUMAN 24.231 260 160 10 110 366 284 509 1.23E-10 67.4 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; P10079 CHOYP_LOC100634060.37.37 m.66998 sp FBP1_STRPU 52.961 304 143 0 1 304 294 597 1.23E-96 310 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10155 CHOYP_BRAFLDRAFT_57459.1.1 m.61613 sp RO60_HUMAN 30.855 538 332 11 10 541 30 533 1.23E-83 273 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P13596 CHOYP_FAS2.1.1 m.41201 sp NCAM1_RAT 27.1 893 535 33 45 891 36 858 1.23E-61 228 NCAM1_RAT reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) Ncam1 Ncam Rattus norvegicus (Rat) 858 aging [GO:0007568]; axon guidance [GO:0007411]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell adhesion [GO:0007155]; cellular response to inorganic substance [GO:0071241]; cellular response to molecule of bacterial origin [GO:0071219]; learning or memory [GO:0007611]; multicellular organismal response to stress [GO:0033555]; negative regulation of cell death [GO:0060548]; neuron development [GO:0048666]; organ regeneration [GO:0031100]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; regulation of sensory perception of pain [GO:0051930]; regulation of synaptic plasticity [GO:0048167]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; response to inorganic substance [GO:0010035]; response to lead ion [GO:0010288]; thalamus development [GO:0021794] GO:0005104; GO:0005886; GO:0007155; GO:0007411; GO:0007568; GO:0007611; GO:0008092; GO:0008201; GO:0010035; GO:0010288; GO:0014012; GO:0016021; GO:0016338; GO:0019902; GO:0021794; GO:0030275; GO:0030426; GO:0031100; GO:0033555; GO:0042220; GO:0042493; GO:0043025; GO:0048167; GO:0048666; GO:0051930; GO:0060045; GO:0060548; GO:0071219; GO:0071241 0 0 0 PF00041;PF07679; P16157 CHOYP_TVAG_020440.1.21 m.3896 sp ANK1_HUMAN 36.857 350 221 0 1 350 212 561 1.23E-59 211 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16230 CHOYP_NEMVEDRAFT_V1G232294.1.1 m.22465 sp SRCH_RABIT 39.56 91 53 2 20 109 754 843 1.23E-20 89.7 SRCH_RABIT reviewed Sarcoplasmic reticulum histidine-rich calcium-binding protein HRC HCP Oryctolagus cuniculus (Rabbit) 852 0 GO:0005509; GO:0033018 0 0 0 PF10529; P22574 CHOYP_HXD4A.1.1 m.10896 sp HXB4A_DANRE 48.163 245 93 8 1 231 1 225 1.23E-61 196 HXB4A_DANRE reviewed Homeobox protein Hox-B4a (Hox-B4) (Homeobox protein Zf-13) hoxb4a hox-b4 hoxb4 zf13 Danio rerio (Zebrafish) (Brachydanio rerio) 246 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007275; GO:0043565 0 0 0 PF00046; P29694 CHOYP_EF1G.1.3 m.12908 sp EF1G_RABIT 56.51 361 141 4 14 358 1 361 1.23E-142 415 EF1G_RABIT reviewed Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) EEF1G Oryctolagus cuniculus (Rabbit) 437 0 GO:0003746 0 0 0 PF00647;PF00043;PF02798; P35590 CHOYP_MEGF6.46.59 m.47521 sp TIE1_HUMAN 33.333 141 70 7 2 125 224 357 1.23E-14 77.8 TIE1_HUMAN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) 1138 angiogenesis [GO:0001525]; in utero embryonic development [GO:0001701]; mesoderm development [GO:0007498]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] GO:0001525; GO:0001570; GO:0001701; GO:0004714; GO:0005524; GO:0005887; GO:0007165; GO:0007498; GO:0016525; GO:0030336; GO:0032526; GO:0045026 0 0 0 PF00041;PF00047;PF07714; P40757 CHOYP_LOC577905.1.2 m.2598 sp ALN_LITCT 57.682 371 156 1 10 379 23 393 1.23E-145 427 ALN_LITCT reviewed "Allantoinase, mitochondrial (EC 3.5.2.5)" ALN Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 484 allantoin catabolic process [GO:0000256] GO:0000256; GO:0004038; GO:0005739; GO:0008270; GO:0050897 PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. 0 0 PF01979; P54727 CHOYP_RD23B.1.1 m.38952 sp RD23B_HUMAN 53.81 420 146 8 1 384 1 408 1.23E-124 368 RD23B_HUMAN reviewed UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58) RAD23B Homo sapiens (Human) 409 "embryonic organ development [GO:0048568]; global genome nucleotide-excision repair [GO:0070911]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; spermatogenesis [GO:0007283]" GO:0000502; GO:0000715; GO:0000717; GO:0003684; GO:0003697; GO:0005634; GO:0005654; GO:0005737; GO:0006289; GO:0006294; GO:0007283; GO:0031593; GO:0032434; GO:0043161; GO:0048568; GO:0070911; GO:0071942 0 0 0 PF00627;PF00240;PF09280; P58003 CHOYP_BRAFLDRAFT_219671.2.2 m.65578 sp SESN1_XENLA 48.971 486 229 7 77 548 1 481 1.23E-162 474 SESN1_XENLA reviewed Sestrin-1 (EC 1.11.1.15) (XPA26) (p53-regulated protein PA26) sesn1 pa26 Xenopus laevis (African clawed frog) 481 negative regulation of TORC1 signaling [GO:1904262]; regulation of response to reactive oxygen species [GO:1901031] GO:0005634; GO:0005737; GO:0051920; GO:0070728; GO:1901031; GO:1904262 0 0 0 PF04636; P81481 CHOYP_VOLCADRAFT_105857.1.1 m.41432 sp IPSG_MUSLU 42.254 71 31 2 32 92 28 98 1.23E-08 52.4 IPSG_MUSLU reviewed "Double-headed protease inhibitor, submandibular gland" 0 Mustela lutreola (European mink) 122 0 GO:0004867; GO:0005576 0 0 0 PF00050; P86952 CHOYP_TYRO.1.1 m.38876 sp TYRO_PINMA 31.831 355 215 9 63 397 55 402 1.23E-44 171 TYRO_PINMA reviewed Tyrosinase-like protein (Tyrosinase-2) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 456 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; Q09225 CHOYP_LOC100888821.1.1 m.2820 sp NRF6_CAEEL 26.062 706 406 22 259 911 153 795 1.23E-69 251 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q09660 CHOYP_LOC100376649.1.4 m.16440 sp CC44_CAEEL 38.664 494 279 13 28 514 11 487 1.23E-111 343 CC44_CAEEL reviewed Probable cytochrome P450 CYP44 (EC 1.14.-.-) cyp-44A1 ccp-44 cyp44 ZK177.5 Caenorhabditis elegans 489 0 GO:0004497; GO:0005506; GO:0016491; GO:0016705; GO:0020037 0 0 0 PF00067; Q24306 CHOYP_TIAP2.1.13 m.15430 sp DIAP1_DROME 47.727 88 46 0 59 146 218 305 1.23E-25 103 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q26636 CHOYP_LOC575203.6.6 m.30705 sp CATL_SARPE 59.236 314 118 5 51 355 27 339 1.23E-129 377 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q28620 CHOYP_THSD4.1.2 m.36523 sp NPT2A_RABIT 59.236 157 61 2 1 155 154 309 1.23E-51 177 NPT2A_RABIT reviewed Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-6) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) SLC34A1 SLC17A2 Oryctolagus cuniculus (Rabbit) 642 phosphate ion homeostasis [GO:0055062]; phosphate ion transport [GO:0006817]; response to cadmium ion [GO:0046686]; response to lead ion [GO:0010288]; response to mercury ion [GO:0046689]; sodium ion transport [GO:0006814] GO:0005886; GO:0006814; GO:0006817; GO:0010288; GO:0015293; GO:0015321; GO:0016021; GO:0046686; GO:0046689; GO:0055062 0 0 0 PF02690; Q28DV3 CHOYP_LOC100372842.1.1 m.26584 sp HDAC3_XENTR 66.116 242 81 1 1 242 188 428 1.23E-120 353 HDAC3_XENTR reviewed Histone deacetylase 3 (HD3) (EC 3.5.1.98) hdac3 TEgg067n06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 428 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003682; GO:0003714; GO:0005634; GO:0005737; GO:0006351; GO:0017053; GO:0032041 0 0 0 PF00850; Q2EY13 CHOYP_LOC101066168.1.1 m.24016 sp PRTGB_DANRE 24.422 303 193 14 120 403 122 407 1.23E-06 54.3 PRTGB_DANRE reviewed Protogenin B (Fragment) prtgb Danio rerio (Zebrafish) (Brachydanio rerio) 1069 multicellular organism development [GO:0007275] GO:0007275; GO:0016021 0 0 0 PF00041;PF07679; Q2T9I9 CHOYP_UAFA.2.8 m.33624 sp TASOR_XENLA 25.333 225 154 7 16 230 67 287 1.23E-16 89.7 TASOR_XENLA reviewed Protein TASOR (Transgene activation suppressor protein) fam208a tasor Xenopus laevis (African clawed frog) 1555 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355 0 0 0 PF12509; Q3MHH4 CHOYP_QARS.1.2 m.12428 sp SYQ_BOVIN 66 300 102 0 1 300 461 760 1.23E-145 432 SYQ_BOVIN reviewed Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) QARS Bos taurus (Bovine) 775 brain development [GO:0007420]; glutaminyl-tRNA aminoacylation [GO:0006425] GO:0003723; GO:0004819; GO:0005524; GO:0005737; GO:0005739; GO:0005829; GO:0006425; GO:0007420 0 0 0 PF00749;PF03950;PF04558;PF04557; Q3TD49 CHOYP_SPP2B.1.1 m.46808 sp SPP2B_MOUSE 42.43 568 278 11 21 555 16 567 1.23E-145 434 SPP2B_MOUSE reviewed Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) Sppl2b Mus musculus (Mouse) 578 membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; signal peptide processing [GO:0006465] GO:0000139; GO:0005654; GO:0005765; GO:0005813; GO:0005886; GO:0006465; GO:0006509; GO:0010008; GO:0015629; GO:0016020; GO:0030660; GO:0031293; GO:0033619; GO:0042500; GO:0042803; GO:0050776; GO:0071458; GO:0071556 0 0 0 PF02225;PF04258; Q3UVC0 CHOYP_PHUM_PHUM291680.1.1 m.59848 sp KSR2_MOUSE 47.664 107 54 1 237 343 855 959 1.23E-27 117 KSR2_MOUSE reviewed Kinase suppressor of Ras 2 (EC 2.7.11.1) Ksr2 Mus musculus (Mouse) 959 calcium-mediated signaling [GO:0019722]; positive regulation of MAPK cascade [GO:0043410] GO:0004674; GO:0005078; GO:0005524; GO:0005829; GO:0005886; GO:0019722; GO:0031434; GO:0043410; GO:0046872 0 0 0 PF13543;PF07714; Q4KLI9 CHOYP_LOC100879491.1.1 m.6988 sp FBXW5_RAT 27.886 563 352 17 6 541 10 545 1.23E-51 189 FBXW5_RAT reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) 569 centrosome duplication [GO:0051298]; mitotic nuclear division [GO:0007067]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000151; GO:0005737; GO:0007067; GO:0010824; GO:0016567; GO:0019005; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q4V7Q8 CHOYP_LOC100518038.1.1 m.1794 sp TM220_XENLA 32.237 152 90 3 20 170 29 168 1.23E-19 84.7 TM220_XENLA reviewed Transmembrane protein 220 tmem220 Xenopus laevis (African clawed frog) 184 0 GO:0016021 0 0 0 PF15071; Q502K3 CHOYP_SECG.3.3 m.43178 sp ANR52_DANRE 41.045 134 79 0 1 134 65 198 1.23E-23 98.6 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q54KA7 CHOYP_AAEL_AAEL014742.6.8 m.64968 sp SECG_DICDI 42 150 87 0 46 195 172 321 1.23E-28 115 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5EA25 CHOYP_LOC582241.1.1 m.27092 sp SRPX2_BOVIN 39.56 182 86 6 77 254 158 319 1.23E-22 104 SRPX2_BOVIN reviewed Sushi repeat-containing protein SRPX2 SRPX2 Bos taurus (Bovine) 465 angiogenesis [GO:0001525]; cell motility [GO:0048870]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphorylation [GO:0042325]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005102; GO:0005615; GO:0005737; GO:0009986; GO:0015630; GO:0016337; GO:0030054; GO:0036458; GO:0042325; GO:0042802; GO:0048870; GO:0051965; GO:0060076; GO:0090050; GO:0097060 0 0 0 PF13778;PF02494;PF00084; Q5ND28 CHOYP_MEGF6.22.59 m.33841 sp SREC_MOUSE 34.762 210 128 6 1 208 215 417 1.23E-24 112 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5R7Y0 CHOYP_TSP2.1.2 m.49303 sp AGRB2_PONAB 31.333 150 84 4 312 461 296 426 1.23E-12 76.6 AGRB2_PONAB reviewed Adhesion G protein-coupled receptor B2 (Brain-specific angiogenesis inhibitor 2) ADGRB2 BAI2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1485 cell surface receptor signaling pathway [GO:0007166]; negative regulation of angiogenesis [GO:0016525] GO:0004930; GO:0005886; GO:0007166; GO:0016021; GO:0016525 0 0 0 PF00002;PF16489;PF01825;PF02793;PF00090; Q5RAQ8 CHOYP_RS24.2.6 m.19166 sp RS24_PONAB 80.702 57 11 0 49 105 74 130 1.23E-23 90.5 RS24_PONAB reviewed 40S ribosomal protein S24 RPS24 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 131 translation [GO:0006412] GO:0000166; GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01282; Q66IV1 CHOYP_LOC589017.1.1 m.3010 sp MRF_XENLA 43.175 718 320 13 250 940 270 926 1.23E-170 533 MRF_XENLA reviewed "Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]" myrf mrf Xenopus laevis (African clawed frog) 1092 "central nervous system myelination [GO:0022010]; central nervous system myelin maintenance [GO:0032286]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of myelination [GO:0031643]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005789; GO:0006351; GO:0008233; GO:0014003; GO:0016021; GO:0022010; GO:0031643; GO:0032286; GO:0045893; GO:0048709 0 0 0 PF13887;PF13888;PF05224;PF13884; Q69Z28 CHOYP_ATS2.2.2 m.42286 sp ATS16_MOUSE 24.479 384 241 11 307 689 276 611 1.23E-23 112 ATS16_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Adamts16 Kiaa2029 Mus musculus (Mouse) 1222 branching involved in ureteric bud morphogenesis [GO:0001658]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] GO:0001658; GO:0003073; GO:0004222; GO:0005578; GO:0008270; GO:1902017 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q6DIB5 CHOYP_MEG10.54.91 m.47504 sp MEG10_MOUSE 39.118 363 196 16 8 362 169 514 1.23E-49 182 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6NV18 CHOYP_LOC754820.1.1 m.57329 sp NHEJ1_DANRE 27.65 217 148 3 26 234 5 220 1.23E-22 99.4 NHEJ1_DANRE reviewed Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) nhej1 xlf zgc:85657 Danio rerio (Zebrafish) (Brachydanio rerio) 309 DNA recombination [GO:0006310]; double-strand break repair [GO:0006302] GO:0003677; GO:0005634; GO:0006302; GO:0006310; GO:0070419 0 0 0 PF09302; Q6P5H6 CHOYP_ISCW_ISCW003928.1.1 m.18079 sp FRMD5_MOUSE 48.696 345 164 6 14 356 16 349 1.23E-109 343 FRMD5_MOUSE reviewed FERM domain-containing protein 5 Frmd5 Mus musculus (Mouse) 517 0 GO:0005737; GO:0005856; GO:0019898 0 0 0 PF08736;PF09380;PF00373;PF09379; Q6PFY8 CHOYP_TRIM45.5.9 m.21479 sp TRI45_MOUSE 28.922 204 128 6 8 205 129 321 1.23E-11 70.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7Z5L3 CHOYP_C1QL2.13.32 m.21135 sp C1QL2_HUMAN 30.973 113 71 3 112 219 159 269 1.23E-07 54.3 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q80T91 CHOYP_LOC579946.20.24 m.55163 sp MEG11_MOUSE 36.007 536 297 26 259 782 105 606 1.23E-70 260 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q80Z37 CHOYP_LOC576802.1.1 m.59457 sp TOPRS_MOUSE 34.226 336 176 6 60 367 98 416 1.23E-50 196 TOPRS_MOUSE reviewed E3 ubiquitin-protein ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3) Topors Mus musculus (Mouse) 1033 "cellular response to DNA damage stimulus [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein localization to nucleus [GO:0034504]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of cell proliferation [GO:0042127]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0000151; GO:0000209; GO:0000922; GO:0000930; GO:0003677; GO:0003823; GO:0004842; GO:0005634; GO:0005814; GO:0006511; GO:0006513; GO:0006974; GO:0008270; GO:0008630; GO:0016605; GO:0016607; GO:0016874; GO:0016925; GO:0019789; GO:0032391; GO:0034504; GO:0036064; GO:0042127; GO:0042771; GO:0043161; GO:0044547; GO:0045893; GO:0051443; GO:0051457; GO:0061630; GO:0070936 0 0 0 0 Q8BSN3 CHOYP_LOC100367974.3.3 m.61377 sp CC151_MOUSE 39.552 536 305 3 12 538 62 587 1.23E-104 329 CC151_MOUSE reviewed Coiled-coil domain-containing protein 151 Ccdc151 Mus musculus (Mouse) 593 cilium movement [GO:0003341]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017] GO:0003341; GO:0005814; GO:0005929; GO:0005930; GO:0007368; GO:0007507; GO:0036064; GO:0036158; GO:0061371; GO:1902017 0 0 0 0 Q8IDX6 CHOYP_LOC100540564.1.1 m.9506 sp RBP2A_PLAF7 37.607 117 62 5 65 177 2742 2851 1.23E-07 58.2 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8IWQ3 CHOYP_BRSK2.1.2 m.31319 sp BRSK2_HUMAN 92.424 132 10 0 1 132 46 177 1.23E-82 261 BRSK2_HUMAN reviewed Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 Homo sapiens (Human) 736 "actin cytoskeleton reorganization [GO:0031532]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitotic nuclear division [GO:0007067]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of ATPase activity [GO:0043462]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]" GO:0000086; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005813; GO:0006468; GO:0006887; GO:0007067; GO:0007409; GO:0018105; GO:0030010; GO:0030182; GO:0031532; GO:0036503; GO:0043462; GO:0048471; GO:0050321; GO:0051117; GO:0051301; GO:0060590; GO:0061178; GO:0070059; GO:1904152 0 0 0 PF00069; Q8IWW6 CHOYP_RHG12.2.2 m.44234 sp RHG12_HUMAN 35.284 598 333 18 18 602 271 827 1.23E-91 305 RHG12_HUMAN reviewed Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) ARHGAP12 Homo sapiens (Human) 846 morphogenesis of an epithelial sheet [GO:0002011]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0002011; GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00169;PF00620;PF14604; Q8IXM2 CHOYP_LOC100718753.1.1 m.19853 sp BAP18_HUMAN 35.766 137 63 4 1 112 34 170 1.23E-13 66.6 BAP18_HUMAN reviewed Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa) BAP18 C17orf49 Homo sapiens (Human) 172 covalent chromatin modification [GO:0016569] GO:0003677; GO:0005654; GO:0005737; GO:0016569; GO:0016589; GO:0071339 0 0 0 0 Q8K0U4 CHOYP_HS12A.18.33 m.51764 sp HS12A_MOUSE 31.715 659 371 18 33 626 29 673 1.23E-99 321 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K0U4 CHOYP_HS12A.29.33 m.61438 sp HS12A_MOUSE 34.365 646 353 16 6 593 32 664 1.23E-107 341 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N2E2 CHOYP_VWDE.9.13 m.40656 sp VWDE_HUMAN 22.844 661 423 25 27 638 32 654 1.23E-24 115 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8STF0 CHOYP_CALM.12.50 m.28147 sp CALM_STRIE 49.677 155 76 2 1 155 1 153 1.23E-46 152 CALM_STRIE reviewed Calmodulin (CaM) 0 Strongylocentrotus intermedius (Sea urchin) 156 0 GO:0005509 0 0 0 PF13499; Q8TEK3 CHOYP_PABP4.2.6 m.22634 sp DOT1L_HUMAN 66.959 342 112 1 4 344 6 347 1.23E-154 522 DOT1L_HUMAN reviewed "Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)" DOT1L KIAA1814 KMT4 Homo sapiens (Human) 1739 chromatin silencing [GO:0006342]; histone H3-K79 methylation [GO:0034729]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of JAK-STAT cascade [GO:0046425]; regulation of transcription regulatory region DNA binding [GO:2000677]; telomere organization [GO:0032200] GO:0003677; GO:0005634; GO:0005654; GO:0006342; GO:0008134; GO:0008284; GO:0018024; GO:0031151; GO:0032200; GO:0034729; GO:0042054; GO:0043234; GO:0045944; GO:0046425; GO:0051726; GO:2000677 0 0 0 PF08123; Q8UVR8 CHOYP_BM1_29990.1.1 m.36222 sp CSF12_TAKRU 29.609 179 114 3 530 708 811 977 1.23E-15 86.3 CSF12_TAKRU reviewed Macrophage colony-stimulating factor 1 receptor 2 (CSF-1-R 2) (EC 2.7.10.1) csf1r2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 1019 cytokine-mediated signaling pathway [GO:0019221]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0005886; GO:0006954; GO:0007169; GO:0016021; GO:0019221; GO:0045087 0 0 0 PF07714; Q8WPJ2 CHOYP_MANA.2.3 m.3293 sp MANA_MYTED 60.234 342 134 1 1 342 17 356 1.23E-155 444 MANA_MYTED reviewed "Mannan endo-1,4-beta-mannosidase (EC 3.2.1.78) (Beta-mannanase) (Endo-beta-1,4-mannanase) (Man5A) (ManA)" 0 Mytilus edulis (Blue mussel) 367 mannan catabolic process [GO:0046355] GO:0016985; GO:0046355 0 0 0 PF00150; Q8WZ42 CHOYP_SAX3.1.1 m.49786 sp TITIN_HUMAN 23.729 354 203 13 11 311 32502 32841 1.23E-09 64.3 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q90369 CHOYP_LOC100378198.1.1 m.14513 sp KALM_COTJA 48.077 52 24 1 395 443 115 166 1.23E-07 57.8 KALM_COTJA reviewed Anosmin-1 (Kallmann syndrome protein homolog) ANOS1 KAL KAL1 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 674 cell adhesion [GO:0007155] GO:0004867; GO:0005576; GO:0007155; GO:0009986 0 0 0 PF00041;PF00095; Q90WJ8 CHOYP_LOC100486681.1.2 m.51975 sp AJL2_ANGJA 27.132 129 87 3 108 230 33 160 1.23E-15 75.1 AJL2_ANGJA reviewed Lactose-binding lectin l-2 (Ajl-2) l-2 Anguilla japonica (Japanese eel) 166 defense response to Gram-negative bacterium [GO:0050829]; induction of bacterial agglutination [GO:0043152] GO:0005576; GO:0030246; GO:0043152; GO:0050829 0 0 0 PF00059; Q92193 CHOYP_CYIIB.1.2 m.15994 sp ACT_CRAVI 97.794 136 3 0 1 136 49 184 1.23E-94 276 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q95029 CHOYP_CATL.1.1 m.34247 sp CATL_DROME 54.286 315 136 2 77 383 57 371 1.23E-119 354 CATL_DROME reviewed Cathepsin L (EC 3.4.22.15) (Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Cp1 fs(2)50Ca CG6692 Drosophila melanogaster (Fruit fly) 371 autophagic cell death [GO:0048102]; digestion [GO:0007586]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; salivary gland cell autophagic cell death [GO:0035071] GO:0004197; GO:0005615; GO:0005764; GO:0006508; GO:0007586; GO:0008233; GO:0035071; GO:0045169; GO:0048102; GO:0051603 0 0 0 PF08246;PF00112; Q95230 CHOYP_LOC580130.1.2 m.15548 sp SP17_PAPHA 43.396 159 73 4 12 160 1 152 1.23E-31 119 SP17_PAPHA reviewed Sperm surface protein Sp17 (Sperm autoantigenic protein 17) SPA17 SP17 Papio hamadryas (Hamadryas baboon) 163 binding of sperm to zona pellucida [GO:0007339] GO:0007339; GO:0016020 0 0 0 PF00612;PF02197; Q96N23 CHOYP_LOC575277.2.2 m.32104 sp CFA54_HUMAN 28.592 1378 767 31 969 2318 1907 3095 1.23E-136 483 CFA54_HUMAN reviewed Cilia- and flagella-associated protein 54 CFAP54 C12orf55 C12orf63 Homo sapiens (Human) 3096 cell differentiation [GO:0030154]; cilium assembly [GO:0042384]; cilium movement involved in cell motility [GO:0060294]; spermatogenesis [GO:0007283] GO:0005737; GO:0005930; GO:0007283; GO:0030154; GO:0042384; GO:0060294 0 0 0 PF14858; Q99MS0 CHOYP_S14L2.1.1 m.8312 sp S14L2_RAT 53.817 262 118 2 1 260 1 261 1.23E-98 298 S14L2_RAT reviewed SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) Sec14l2 Rattus norvegicus (Rat) 403 "positive regulation of cholesterol biosynthetic process [GO:0045542]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005215; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0008047; GO:0008289; GO:0016021; GO:0016765; GO:0045542 0 0 0 PF00650; Q9BXT4 CHOYP_TDRD1.1.1 m.34821 sp TDRD1_HUMAN 30.519 154 99 6 1 153 490 636 1.23E-10 70.1 TDRD1_HUMAN reviewed Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) TDRD1 Homo sapiens (Human) 1180 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0005737; GO:0007275; GO:0007281; GO:0007283; GO:0031047; GO:0033391; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; Q9C0B7 CHOYP_TMCO7.1.1 m.14841 sp TNG6_HUMAN 35.132 871 483 14 334 1158 258 1092 1.23E-153 491 TNG6_HUMAN reviewed Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7) TANGO6 KIAA1746 TMCO7 Homo sapiens (Human) 1094 0 GO:0016021 0 0 0 PF10363;PF10304; Q9CQI4 CHOYP_contig_012500 m.14381 sp CK074_MOUSE 36.697 109 53 4 247 352 130 225 1.23E-06 52.4 CK074_MOUSE reviewed Uncharacterized protein C11orf74 homolog (Protein NWC) Nwc Mus musculus (Mouse) 244 0 0 0 0 0 0 Q9CWT6 CHOYP_BRE.1.1 m.11411 sp DDX28_MOUSE 33.117 154 95 5 16 165 22 171 1.23E-12 67.8 DDX28_MOUSE reviewed Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) Ddx28 Mus musculus (Mouse) 540 mitochondrial large ribosomal subunit assembly [GO:1902775]; RNA secondary structure unwinding [GO:0010501] GO:0004004; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0010501; GO:0019843; GO:0035770; GO:0042645; GO:0044822; GO:1902775 0 0 0 PF00270;PF00271; Q9DBV3 CHOYP_NEMVEDRAFT_V1G241791.1.2 m.4464 sp DHX34_MOUSE 43.75 192 99 3 92 282 30 213 1.23E-42 159 DHX34_MOUSE reviewed Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) Dhx34 Ddx34 Kiaa0134 Mus musculus (Mouse) 1145 "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; RNA processing [GO:0006396]" GO:0000956; GO:0004004; GO:0005524; GO:0005634; GO:0005739; GO:0006396; GO:0016020; GO:0044822; GO:2000623 0 0 0 PF00270;PF04408;PF00271;PF07717; Q9GV72 CHOYP_contig_029390 m.33329 sp CTX1_CARRA 21.324 408 273 16 5 393 50 428 1.23E-07 57.4 CTX1_CARRA reviewed Toxin CrTX-A (CRT-1) (CrTX-B) (Toxin 1) 0 Carybdea rastonii (Box jellyfish) 450 hemolysis in other organism [GO:0044179]; ion transport [GO:0006811] GO:0005576; GO:0006811; GO:0016021; GO:0042151; GO:0044179; GO:0044218 0 0 0 0 Q9NQR1 CHOYP_LOC100892236.1.7 m.3046 sp KMT5A_HUMAN 37.063 143 80 6 46 184 257 393 1.23E-16 81.3 KMT5A_HUMAN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A PRSET7 SET07 SET8 SETD8 Homo sapiens (Human) 393 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006351; GO:0007067; GO:0016278; GO:0016279; GO:0018024; GO:0018026; GO:0042799; GO:0043516; GO:0045892; GO:0051301; GO:1901796 0 0 0 PF00856; Q9NY59 CHOYP_BRAFLDRAFT_99405.1.1 m.41724 sp NSMA2_HUMAN 29.6 125 73 2 2 121 532 646 1.23E-13 69.3 NSMA2_HUMAN reviewed Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) SMPD3 Homo sapiens (Human) 655 cell cycle [GO:0007049]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; peptide hormone secretion [GO:0030072]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of exosomal secretion [GO:1903543]; sphingomyelin catabolic process [GO:0006685] GO:0000137; GO:0000139; GO:0002244; GO:0004767; GO:0005886; GO:0006685; GO:0006687; GO:0007049; GO:0030072; GO:0046872; GO:1903543; GO:2000304 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF03372; Q9NZN5 CHOYP_LOC100644321.4.7 m.44352 sp ARHGC_HUMAN 43.702 389 201 8 830 1203 755 1140 1.23E-79 295 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q9P2P6 CHOYP_CPSF2.1.1 m.13909 sp STAR9_HUMAN 28.947 190 126 7 471 657 4515 4698 1.23E-13 78.6 STAR9_HUMAN reviewed StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9) STARD9 KIAA1300 Homo sapiens (Human) 4700 cytoskeleton-dependent intracellular transport [GO:0030705]; metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225] GO:0003777; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005814; GO:0005871; GO:0007018; GO:0008017; GO:0008152; GO:0008289; GO:0016887; GO:0030705; GO:0051225 0 0 0 PF00498;PF00225;PF01852; Q9TT38 CHOYP_PGH2.2.2 m.39368 sp PA24A_RABIT 47.319 429 199 5 1 423 326 733 1.23E-128 392 PA24A_RABIT reviewed Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 Oryctolagus cuniculus (Rabbit) 748 phospholipid catabolic process [GO:0009395] GO:0004622; GO:0004623; GO:0005509; GO:0005544; GO:0009395; GO:0016023 0 0 0 PF00168;PF01735; Q9UJU3 CHOYP_ZN493.1.1 m.529 sp ZN112_HUMAN 34.111 343 216 7 290 631 494 827 1.23E-46 185 ZN112_HUMAN reviewed Zinc finger protein 112 (Zfp-112) (Zinc finger protein 228) ZNF112 ZFP112 ZNF228 Homo sapiens (Human) 913 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q9VZN4 CHOYP_EF1A.4.4 m.65744 sp DAR1_DROME 80.952 105 20 0 369 473 647 751 1.23E-54 197 DAR1_DROME reviewed Dendritic arbor reduction protein 1 dar1 CG12029 Drosophila melanogaster (Fruit fly) 751 "negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0007026; GO:0043565; GO:0045944; GO:0046872; GO:0050775; GO:1903861 0 0 0 0 Q9VZN4 CHOYP_MGC89016.2.2 m.46316 sp DAR1_DROME 80.952 105 20 0 369 473 647 751 1.23E-54 197 DAR1_DROME reviewed Dendritic arbor reduction protein 1 dar1 CG12029 Drosophila melanogaster (Fruit fly) 751 "negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dendrite extension [GO:1903861]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0007026; GO:0043565; GO:0045944; GO:0046872; GO:0050775; GO:1903861 0 0 0 0 Q9WU25 CHOYP_contig_031257 m.35675 sp ADA1A_CAVPO 21.534 339 229 12 26 345 29 349 1.23E-06 53.9 ADA1A_CAVPO reviewed Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) ADRA1A Cavia porcellus (Guinea pig) 466 positive regulation of MAPK cascade [GO:0043410]; regulation of cardiac muscle contraction [GO:0055117]; regulation of vasoconstriction [GO:0019229] GO:0004937; GO:0005634; GO:0005886; GO:0016021; GO:0019229; GO:0031965; GO:0043410; GO:0046982; GO:0055117 0 0 0 PF00001; Q9ZCL3 CHOYP_contig_015682 m.18342 sp Y714_RICPR 38.947 95 55 2 11 105 6 97 1.23E-09 57.8 Y714_RICPR reviewed Putative ankyrin repeat protein RP714 RP714 Rickettsia prowazekii (strain Madrid E) 107 0 0 0 0 0 PF00023; A4IIC5 CHOYP_LOC100372290.1.2 m.4570 sp S39A3_XENTR 29.595 321 196 7 5 315 6 306 1.24E-29 118 S39A3_XENTR reviewed Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) slc39a3 zip3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 314 zinc II ion transmembrane transport [GO:0071577] GO:0005385; GO:0005886; GO:0016021; GO:0071577 0 0 0 PF02535; B2RZ39 CHOYP_RM36.1.1 m.43815 sp RM36_RAT 36.667 60 37 1 43 101 38 97 1.24E-06 47.4 RM36_RAT reviewed "39S ribosomal protein L36, mitochondrial (L36mt) (MRP-L36)" Mrpl36 Rattus norvegicus (Rat) 97 ribosome biogenesis [GO:0042254]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005840; GO:0006412; GO:0042254 0 0 0 PF00444; B3DK56 CHOYP_PTPRU.1.2 m.23416 sp PTPRU_DANRE 27.907 473 325 9 1 464 973 1438 1.24E-51 192 PTPRU_DANRE reviewed Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) ptpru rptppsi Danio rerio (Zebrafish) (Brachydanio rerio) 1444 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; somite specification [GO:0001757] GO:0001757; GO:0004725; GO:0005886; GO:0007155; GO:0016021; GO:0030054; GO:0030154 0 0 cd06263; PF00041;PF00629;PF00102; B4F6I5 CHOYP_PHUM_PHUM378440.1.1 m.8299 sp FICD_XENTR 60.234 342 134 2 87 428 83 422 1.24E-148 433 FICD_XENTR reviewed Adenosine monophosphate-protein transferase FICD (EC 2.7.7.n1) (AMPylator FICD) (FIC domain-containing protein) ficd Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 446 protein adenylylation [GO:0018117] GO:0005524; GO:0016021; GO:0018117; GO:0070733 0 0 0 PF02661; D2GXS7 CHOYP_BRAFLDRAFT_82426.15.20 m.57586 sp TRIM2_AILME 24.28 243 150 9 172 401 523 744 1.24E-08 60.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5E8K5 CHOYP_LOC752844.1.4 m.306 sp ANK3_MOUSE 30.798 263 177 2 33 294 507 765 1.24E-29 124 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; I1VZH0 CHOYP_LOC100369754.6.10 m.53352 sp RN207_RABIT 22.439 205 144 6 15 217 103 294 1.24E-09 64.3 RN207_RABIT reviewed RING finger protein 207 RNF207 Oryctolagus cuniculus (Rabbit) 594 0 GO:0005737; GO:0008270 0 0 0 PF00643; O08715 CHOYP_PHUM_PHUM233260.1.1 m.6315 sp AKAP1_MOUSE 40.974 349 184 6 399 746 524 851 1.24E-83 286 AKAP1_MOUSE reviewed "A-kinase anchor protein 1, mitochondrial (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein) (S-AKAP)" Akap1 Akap Mus musculus (Mouse) 857 cellular response to cAMP [GO:0071320]; cellular response to peptide hormone stimulus [GO:0071375]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of NFAT protein import into nucleus [GO:0051534]; negative regulation of protein dephosphorylation [GO:0035308]; regulation of protein kinase A signaling [GO:0010738] GO:0005739; GO:0005741; GO:0005759; GO:0005783; GO:0005811; GO:0010614; GO:0010738; GO:0016020; GO:0016021; GO:0030061; GO:0031594; GO:0034237; GO:0035308; GO:0044822; GO:0045211; GO:0051534; GO:0071320; GO:0071375 0 0 0 PF00013;PF00567; O35867 CHOYP_PHUM_PHUM305910.1.2 m.58404 sp NEB1_RAT 39.226 594 228 16 785 1368 433 903 1.24E-86 311 NEB1_RAT reviewed Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (PP1bp175) (Protein phosphatase 1 regulatory subunit 9A) (p180) Ppp1r9a Rattus norvegicus (Rat) 1095 actin filament organization [GO:0007015]; aging [GO:0007568]; calcium-mediated signaling [GO:0019722]; cellular response to toxic substance [GO:0097237]; excitatory postsynaptic potential [GO:0060079]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of stress fiber assembly [GO:0051497]; neuron development [GO:0048666]; neuron projection development [GO:0031175]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of long term synaptic depression [GO:1900454]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; regulation of actin filament polymerization [GO:0030833]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; regulation of synapse structural plasticity [GO:0051823] GO:0005829; GO:0005856; GO:0007015; GO:0007568; GO:0008022; GO:0008157; GO:0010976; GO:0014069; GO:0015629; GO:0019722; GO:0019901; GO:0019904; GO:0030027; GO:0030054; GO:0030175; GO:0030425; GO:0030426; GO:0030833; GO:0030864; GO:0031175; GO:0031594; GO:0032403; GO:0042803; GO:0043005; GO:0043025; GO:0043197; GO:0044325; GO:0044326; GO:0045202; GO:0045860; GO:0048666; GO:0051015; GO:0051020; GO:0051489; GO:0051497; GO:0051823; GO:0051963; GO:0060079; GO:0060999; GO:0061001; GO:0097237; GO:1900272; GO:1900454; GO:1904049; GO:1990761 0 0 0 PF00595;PF07647; O73810 CHOYP_5-HT2.1.1 m.1383 sp DRD2_MELGA 35.021 474 242 15 47 503 12 436 1.24E-74 246 DRD2_MELGA reviewed D(2) dopamine receptor (Dopamine D2 receptor) DRD2 Meleagris gallopavo (Common turkey) 436 adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; negative regulation of calcium ion transport into cytosol [GO:0010523] GO:0004872; GO:0004952; GO:0005887; GO:0007195; GO:0010523; GO:0035240 0 0 0 PF00001; O75382 CHOYP_LOC100373444.18.79 m.20659 sp TRIM3_HUMAN 23.132 281 171 12 304 560 485 744 1.24E-11 71.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O93574 CHOYP_RELN.2.4 m.41110 sp RELN_CHICK 43.784 185 101 2 1 183 459 642 1.24E-44 160 RELN_CHICK reviewed Reelin (EC 3.4.21.-) (Fragment) RELN Gallus gallus (Chicken) 3209 axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell morphogenesis involved in differentiation [GO:0000904]; central nervous system development [GO:0007417]; cerebral cortex tangential migration [GO:0021800]; glial cell differentiation [GO:0010001]; neuron migration [GO:0001764]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; response to pain [GO:0048265]; spinal cord patterning [GO:0021511]; ventral spinal cord development [GO:0021517] GO:0000904; GO:0001764; GO:0004712; GO:0005578; GO:0005615; GO:0005737; GO:0007155; GO:0007411; GO:0007417; GO:0007420; GO:0008236; GO:0010001; GO:0018108; GO:0021511; GO:0021517; GO:0021800; GO:0030425; GO:0045860; GO:0046872; GO:0048265; GO:0051057 0 0 0 PF07974; O95831 CHOYP_AIFM1.1.1 m.1582 sp AIFM1_HUMAN 47.135 541 262 8 70 601 83 608 1.24E-157 468 AIFM1_HUMAN reviewed "Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8)" AIFM1 AIF PDCD8 Homo sapiens (Human) 613 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cell redox homeostasis [GO:0045454]; cellular response to aldosterone [GO:1904045]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to nitric oxide [GO:0071732]; cellular response to oxygen-glucose deprivation [GO:0090650]; chromosome condensation [GO:0030261]; DNA catabolic process [GO:0006308]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitochondrial respiratory chain complex I assembly [GO:0032981]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of apoptotic DNA fragmentation [GO:1902510]; response to ischemia [GO:0002931]; response to L-glutamate [GO:1902065]; response to toxic substance [GO:0009636] GO:0002931; GO:0003677; GO:0005634; GO:0005739; GO:0005743; GO:0005758; GO:0005829; GO:0006308; GO:0006915; GO:0006919; GO:0009055; GO:0009636; GO:0016174; GO:0016651; GO:0030182; GO:0030261; GO:0032981; GO:0043065; GO:0043525; GO:0045454; GO:0048471; GO:0051402; GO:0070059; GO:0070301; GO:0071392; GO:0071732; GO:0071949; GO:0090650; GO:1902065; GO:1902510; GO:1904045 0 0 0 PF14721;PF07992; P00377 CHOYP_DYR.1.1 m.18526 sp DYR_PIG 33.514 185 109 3 12 189 7 184 1.24E-33 120 DYR_PIG reviewed Dihydrofolate reductase (EC 1.5.1.3) DHFR Sus scrofa (Pig) 186 glycine biosynthetic process [GO:0006545]; nucleotide biosynthetic process [GO:0009165]; one-carbon metabolic process [GO:0006730]; response to methotrexate [GO:0031427]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653] GO:0003729; GO:0004146; GO:0006545; GO:0006730; GO:0008144; GO:0009165; GO:0031427; GO:0046653; GO:0046654; GO:0050661 "PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1." 0 cd00209; PF00186; P04113 CHOYP_MLRA.2.3 m.26582 sp MLRA_MIZYE 72 75 21 0 5 79 1 75 1.24E-32 114 MLRA_MIZYE reviewed "Myosin regulatory light chain A, smooth adductor muscle" 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 161 0 GO:0005509; GO:0016459 0 0 0 PF13405; P0C872 CHOYP_BRAFLDRAFT_90706.2.2 m.29118 sp JMJD7_MOUSE 52.941 136 64 0 18 153 18 153 1.24E-48 161 JMJD7_MOUSE reviewed JmjC domain-containing protein 7 (Jumonji domain-containing protein 7) Jmjd7 Mus musculus (Mouse) 316 0 0 0 0 0 0 P10079 CHOYP_LOC100634060.18.37 m.38606 sp FBP1_STRPU 55.459 229 102 0 27 255 176 404 1.24E-73 252 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_LOC590098.1.1 m.38433 sp FBP1_STRPU 53.02 149 70 0 1 149 371 519 1.24E-45 168 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P17178 CHOYP_BRAFLDRAFT_91871.3.3 m.61891 sp CP27A_RAT 22.581 279 183 7 27 288 41 303 1.24E-14 77.4 CP27A_RAT reviewed "Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)" Cyp27a1 Cyp27 Rattus norvegicus (Rat) 533 cholesterol metabolic process [GO:0008203]; steroid catabolic process [GO:0006706] GO:0005506; GO:0005739; GO:0005740; GO:0006706; GO:0008203; GO:0016705; GO:0020037; GO:0030343; GO:0031073; GO:0031966 PATHWAY: Hormone biosynthesis; cholecalciferol biosynthesis. 0 0 PF00067; P20825 CHOYP_POL4.4.4 m.66248 sp POL2_DROME 33.037 675 415 12 63 723 163 814 1.24E-111 366 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P21439 CHOYP_LOC100375660.1.1 m.18998 sp MDR3_HUMAN 46.774 186 87 2 37 222 45 218 1.24E-47 171 MDR3_HUMAN reviewed Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 3) ABCB4 MDR3 PGY3 Homo sapiens (Human) 1286 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; phospholipid translocation [GO:0045332]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to drug [GO:0042493]; response to fenofibrate [GO:1901557]; transmembrane transport [GO:0055085]; transport [GO:0006810]" GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005524; GO:0005548; GO:0005737; GO:0005886; GO:0005887; GO:0006629; GO:0006810; GO:0008525; GO:0008559; GO:0016020; GO:0016324; GO:0030136; GO:0032376; GO:0032782; GO:0042493; GO:0042626; GO:0045121; GO:0045332; GO:0046581; GO:0055085; GO:0055088; GO:0061092; GO:0070062; GO:0090554; GO:1901557; GO:1903413; GO:2001140 0 0 0 PF00664;PF00005; P24044 CHOYP_CALM3.1.1 m.7125 sp CALM_PLAFA 38.393 112 68 1 1 112 37 147 1.24E-26 99.4 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; P24781 CHOYP_BRAC2.1.1 m.11972 sp BRAC_XENLA 55.353 439 169 11 28 450 5 432 1.24E-154 448 BRAC_XENLA reviewed Brachyury protein (xBRA) (Protein T) t bra Xenopus laevis (African clawed frog) 432 "cellular response to fibroblast growth factor stimulus [GO:0044344]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000578; GO:0001102; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007368; GO:0044344; GO:0045893; GO:0045944 0 0 0 PF00907; P25228 CHOYP_LOC100533330.1.2 m.2565 sp RAB3_DROME 84.234 222 30 2 1 219 1 220 1.24E-137 387 RAB3_DROME reviewed Ras-related protein Rab-3 Rab3 CG7576 Drosophila melanogaster (Fruit fly) 220 cytoskeletal matrix organization at active zone [GO:0048789]; exocytosis [GO:0006887]; maintenance of presynaptic active zone structure [GO:0048790]; neurotransmitter secretion [GO:0007269]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic membrane [GO:0031630]; vesicle-mediated transport [GO:0016192] GO:0003924; GO:0005525; GO:0006887; GO:0007269; GO:0008021; GO:0015031; GO:0016192; GO:0030054; GO:0031630; GO:0031982; GO:0032482; GO:0045202; GO:0048172; GO:0048786; GO:0048789; GO:0048790 0 0 0 PF00071; P27085 CHOYP_RS26.13.15 m.52562 sp RS26_OCTVU 91.089 101 9 0 1 101 1 101 1.24E-64 194 RS26_OCTVU reviewed 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) 127 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01283; P31478 CHOYP_LOC100113561.1.1 m.37903 sp VATF_MANSE 73.95 119 31 0 3 121 4 122 1.24E-62 189 VATF_MANSE reviewed V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F) VHA14 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 124 ATP hydrolysis coupled proton transport [GO:0015991] GO:0015991; GO:0033180; GO:0046961 0 0 0 PF01990; P32004 CHOYP_CNTN5.3.5 m.34362 sp L1CAM_HUMAN 24.877 406 245 17 40 417 48 421 1.24E-21 102 L1CAM_HUMAN reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) L1CAM CAML1 MIC5 Homo sapiens (Human) 1257 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; leukocyte migration [GO:0050900]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773] GO:0005886; GO:0005925; GO:0006935; GO:0007155; GO:0007399; GO:0007411; GO:0009986; GO:0016021; GO:0044295; GO:0045773; GO:0050900 0 0 0 PF13882;PF00041;PF07679; P57756 CHOYP_FGL2.8.9 m.63485 sp FCN2_RAT 51.913 183 85 3 64 245 123 303 1.24E-50 171 FCN2_RAT reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Rattus norvegicus (Rat) 319 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0033691; GO:0046872 0 0 0 PF01391;PF00147; P62972 CHOYP_UBIQP.2.13 m.12408 sp UBIQP_XENLA 100 124 0 0 1 124 6 129 1.24E-84 247 UBIQP_XENLA reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Xenopus laevis (African clawed frog) 167 0 GO:0005634; GO:0005737 0 0 0 PF00240; P76536 CHOYP_LOC100863386.1.1 m.37225 sp YFEX_ECOLI 32.143 280 171 9 87 358 17 285 1.24E-32 126 YFEX_ECOLI reviewed Probable deferrochelatase/peroxidase YfeX (EC 1.11.1.-) yfeX b2431 JW2424 Escherichia coli (strain K12) 299 0 GO:0004601; GO:0005737; GO:0005829; GO:0020037; GO:0046872 0 0 0 PF04261; P86854 CHOYP_CD209A.1.2 m.52338 sp PLCL_MYTGA 27.742 155 105 3 3 150 2 156 1.24E-18 80.5 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P86854 CHOYP_LOC764768.2.2 m.47443 sp PLCL_MYTGA 28.105 153 104 4 1 150 7 156 1.24E-18 80.9 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P86958 CHOYP_DRP.1.1 m.44406 sp USP1_PINMA 47.674 86 44 1 1 86 1 85 1.24E-21 87 USP1_PINMA reviewed Uncharacterized shell protein 1 (Prism uncharacterized shell protein 2) (PUSP2) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 158 0 GO:0005576 0 0 0 0 Q02224 CHOYP_LOC576192.1.1 m.46844 sp CENPE_HUMAN 37.127 738 352 21 4 671 7 702 1.24E-108 392 CENPE_HUMAN reviewed Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-related protein CENPE) CENPE Homo sapiens (Human) 2701 "antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic chromosome movement towards spindle pole [GO:0007079]; mitotic metaphase plate congression [GO:0007080]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; sister chromatid cohesion [GO:0007062]" GO:0000278; GO:0000775; GO:0000776; GO:0000777; GO:0000779; GO:0003777; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0005829; GO:0005871; GO:0005874; GO:0006890; GO:0007018; GO:0007059; GO:0007062; GO:0007079; GO:0007080; GO:0007275; GO:0015630; GO:0016020; GO:0016887; GO:0019886; GO:0030071; GO:0030496; GO:0043515; GO:0045860; GO:0051301; GO:0051315; GO:0051382; GO:1990023 0 0 0 PF00225; Q03348 CHOYP_PTPRE.11.19 m.42349 sp PTPRA_RAT 28.999 669 430 18 275 917 142 791 1.24E-75 267 PTPRA_RAT reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) 796 oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714] GO:0004725; GO:0005886; GO:0016021; GO:0032403; GO:0043231; GO:0048709; GO:0048714 0 0 0 PF00102; Q06852 CHOYP_LOC100535301.3.5 m.26555 sp SLAP1_CLOTH 50 150 52 8 126 252 1456 1605 1.24E-06 55.1 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q13112 CHOYP_CAF1B.4.4 m.51019 sp CAF1B_HUMAN 44.545 440 176 7 20 404 1 427 1.24E-127 383 CAF1B_HUMAN reviewed Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) (M-phase phosphoprotein 7) CHAF1B CAF1A CAF1P60 MPHOSPH7 MPP7 Homo sapiens (Human) 559 "cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; protein complex assembly [GO:0006461]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; xenophagy [GO:0098792]" GO:0000790; GO:0002230; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006281; GO:0006335; GO:0006351; GO:0006355; GO:0006461; GO:0007049; GO:0031497; GO:0033186; GO:0042393; GO:0043234; GO:0051082; GO:0098779; GO:0098792 0 0 0 PF15512;PF00400; Q14676 CHOYP_LOC100489926.1.3 m.3642 sp MDC1_HUMAN 43.415 205 114 1 1509 1711 1877 2081 1.24E-53 211 MDC1_HUMAN reviewed Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) MDC1 KIAA0170 NFBD1 Homo sapiens (Human) 2089 double-strand break repair via nonhomologous end joining [GO:0006303]; intra-S DNA damage checkpoint [GO:0031573]; protein sumoylation [GO:0016925] GO:0005634; GO:0005654; GO:0005694; GO:0005925; GO:0006303; GO:0008022; GO:0016925; GO:0031573; GO:0070975 0 0 0 PF00498;PF16770; Q14676 CHOYP_LOC582503.1.1 m.26336 sp MDC1_HUMAN 43.415 205 114 1 1162 1364 1877 2081 1.24E-54 214 MDC1_HUMAN reviewed Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) MDC1 KIAA0170 NFBD1 Homo sapiens (Human) 2089 double-strand break repair via nonhomologous end joining [GO:0006303]; intra-S DNA damage checkpoint [GO:0031573]; protein sumoylation [GO:0016925] GO:0005634; GO:0005654; GO:0005694; GO:0005925; GO:0006303; GO:0008022; GO:0016925; GO:0031573; GO:0070975 0 0 0 PF00498;PF16770; Q17QL9 CHOYP_TMEM184C.1.1 m.44305 sp T184C_BOVIN 54.95 404 160 4 7 407 10 394 1.24E-158 461 T184C_BOVIN reviewed Transmembrane protein 184C (Transmembrane protein 34) TMEM184C TMEM34 Bos taurus (Bovine) 438 transport [GO:0006810] GO:0005215; GO:0006810; GO:0016021 0 0 0 PF03619; Q1HG43 CHOYP_LOC576350.2.2 m.49307 sp DOXA1_HUMAN 33.115 305 186 5 18 317 10 301 1.24E-43 159 DOXA1_HUMAN reviewed Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) 343 hydrogen peroxide metabolic process [GO:0042743]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609] GO:0005789; GO:0005886; GO:0015031; GO:0016020; GO:0016021; GO:0042743; GO:0045666; GO:0050727; GO:2000379; GO:2000609 0 0 0 PF10204; Q1MSJ5 CHOYP_CSPP1.5.14 m.30798 sp CSPP1_HUMAN 33.793 725 365 25 900 1557 549 1225 1.24E-48 194 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q24372 CHOYP_LACH.1.1 m.62529 sp LACH_DROME 31.269 323 189 10 76 390 59 356 1.24E-34 134 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q2TJA6 CHOYP_NKD1.1.1 m.62818 sp NKD1_DANRE 34.848 198 98 8 1 174 1 191 1.24E-21 100 NKD1_DANRE reviewed Protein naked cuticle homolog 1 (Naked-1) nkd1 Danio rerio (Zebrafish) (Brachydanio rerio) 440 embryonic heart tube left/right pattern formation [GO:0060971]; eye photoreceptor cell differentiation [GO:0001754]; heart jogging [GO:0003146]; Kupffer's vesicle development [GO:0070121]; left/right pattern formation [GO:0060972]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catenin import into nucleus [GO:0035414]; neural plate morphogenesis [GO:0001839]; regulation of cell motility involved in somitogenic axis elongation [GO:0090249]; somatic muscle development [GO:0007525]; Spemann organizer formation [GO:0060061]; Wnt signaling pathway [GO:0016055] GO:0001754; GO:0001839; GO:0003146; GO:0005509; GO:0005737; GO:0005886; GO:0007525; GO:0016055; GO:0035414; GO:0060061; GO:0060971; GO:0060972; GO:0070121; GO:0090090; GO:0090249 0 0 0 0 Q40588 CHOYP_LOC100376857.6.7 m.64115 sp ASO_TOBAC 26.733 606 336 20 156 737 45 566 1.24E-48 185 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q4QQV2 CHOYP_LOC101067777.1.1 m.52432 sp DOK1_RAT 36.667 120 65 5 109 222 125 239 1.24E-11 70.9 DOK1_RAT reviewed Docking protein 1 (Downstream of tyrosine kinase 1) Dok1 Rattus norvegicus (Rat) 480 Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005057; GO:0005634; GO:0005737; GO:0007169; GO:0007265 0 0 0 PF02174;PF00169; Q4V8R6 CHOYP_LOC100694005.1.1 m.14078 sp E4F1_DANRE 39.833 359 175 8 461 788 320 668 1.24E-71 254 E4F1_DANRE reviewed Transcription factor E4F1 (EC 6.3.2.-) (Putative E3 ubiquitin-protein ligase E4F1) (Transcription factor E4F) e4f1 zgc:114190 Danio rerio (Zebrafish) (Brachydanio rerio) 719 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of cell cycle process [GO:0010564]; regulation of growth [GO:0040008]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0003700; GO:0005654; GO:0005737; GO:0006351; GO:0007067; GO:0010564; GO:0016567; GO:0016874; GO:0040008; GO:0046872; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13912; Q54M77 CHOYP_BRAFLDRAFT_129004.13.15 m.55224 sp ROCO8_DICDI 23.03 330 170 13 233 529 820 1098 1.24E-07 59.3 ROCO8_DICDI reviewed Probable serine/threonine-protein kinase roco8 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 8) roco8 DDB_G0286127 Dictyostelium discoideum (Slime mold) 1867 small GTPase mediated signal transduction [GO:0007264] GO:0004674; GO:0005524; GO:0005525; GO:0005622; GO:0007264 0 0 0 PF16095;PF00610;PF13855;PF07714;PF08477; Q5D013 CHOYP_RAB7A.1.2 m.23789 sp MET10_DANRE 46.977 215 107 2 10 224 22 229 1.24E-70 218 MET10_DANRE reviewed Protein-lysine N-methyltransferase mettl10 (EC 2.1.1.-) (Methyltransferase-like protein 10) mettl10 zgc:110805 Danio rerio (Zebrafish) (Brachydanio rerio) 233 0 GO:0005737; GO:0016279 0 0 0 PF13847; Q5E980 CHOYP_BRAFLDRAFT_265292.1.2 m.1306 sp CP20A_BOVIN 32.278 474 300 8 8 473 1 461 1.24E-79 258 CP20A_BOVIN reviewed Cytochrome P450 20A1 (EC 1.14.-.-) CYP20A1 Bos taurus (Bovine) 462 0 GO:0004497; GO:0005506; GO:0016021; GO:0016705; GO:0020037 0 0 0 PF00067; Q5F4B8 CHOYP_LOC556497.1.1 m.21340 sp S46A3_CHICK 24.206 252 184 4 32 278 10 259 1.24E-15 80.1 S46A3_CHICK reviewed Solute carrier family 46 member 3 SLC46A3 RCJMB04_1c21 Gallus gallus (Chicken) 464 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q5I7T1 CHOYP_ALDH1L.1.1 m.14174 sp AG10B_HUMAN 40.462 346 188 7 27 366 18 351 1.24E-72 236 AG10B_HUMAN reviewed "Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) (Alpha-1,2-glucosyltransferase ALG10-A) (Alpha-2-glucosyltransferase ALG10-B) (Asparagine-linked glycosylation protein 10 homolog B) (Potassium channel regulator 1)" ALG10B KCR1 Homo sapiens (Human) 473 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486] GO:0004583; GO:0005789; GO:0005886; GO:0006486; GO:0006488; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04922; Q5IS75 CHOYP_LOC100376843.1.1 m.30170 sp ACHB3_PANTR 28.339 307 208 4 10 308 25 327 1.24E-40 152 ACHB3_PANTR reviewed Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Pan troglodytes (Chimpanzee) 458 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; Q5T089 CHOYP_LOC100027727.1.1 m.22566 sp MORN1_HUMAN 44.907 216 107 2 57 272 26 229 1.24E-56 192 MORN1_HUMAN reviewed MORN repeat-containing protein 1 MORN1 Homo sapiens (Human) 497 0 0 0 0 0 PF02493; Q5VU97 CHOYP_LOC100183158.1.2 m.39063 sp CAHD1_HUMAN 24.336 1130 770 36 7 1085 25 1120 1.24E-93 330 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q5VZ66 CHOYP_FAZ1.1.2 m.13339 sp JKIP3_HUMAN 27.833 503 315 17 73 550 299 778 1.24E-21 105 JKIP3_HUMAN reviewed Janus kinase and microtubule-interacting protein 3 (Neuroendocrine long coiled-coil protein 2) JAKMIP3 C10orf14 C10orf39 JAMIP3 NECC2 Homo sapiens (Human) 844 0 GO:0005794 0 0 0 PF16034; Q60738 CHOYP_LOC100677972.1.1 m.12181 sp ZNT1_MOUSE 40.969 454 176 11 10 389 10 445 1.24E-98 306 ZNT1_MOUSE reviewed Zinc transporter 1 (ZnT-1) (Solute carrier family 30 member 1) Slc30a1 Znt1 Mus musculus (Mouse) 503 cadmium ion transmembrane transport [GO:0070574]; calcium ion import [GO:0070509]; cellular calcium ion homeostasis [GO:0006874]; cellular zinc ion homeostasis [GO:0006882]; detoxification of cadmium ion [GO:0071585]; in utero embryonic development [GO:0001701]; negative regulation of calcium ion import [GO:0090281]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of zinc ion transmembrane import [GO:0071584]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; zinc II ion transport [GO:0006829] GO:0001701; GO:0005385; GO:0005737; GO:0005783; GO:0005794; GO:0005886; GO:0006829; GO:0006874; GO:0006882; GO:0010043; GO:0016021; GO:0019855; GO:0030315; GO:0031965; GO:0046929; GO:0061088; GO:0070509; GO:0070574; GO:0071584; GO:0071585; GO:0090281 0 0 0 PF01545; Q66KB9 CHOYP_BL1S2.1.1 m.11618 sp BL1S2_XENTR 63.333 120 44 0 15 134 28 147 1.24E-47 153 BL1S2_XENTR reviewed Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) bloc1s2 TTpA018b22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 147 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; lysosome localization [GO:0032418]; neuron projection development [GO:0031175] GO:0005815; GO:0008089; GO:0031175; GO:0032418; GO:0043234; GO:0048490; GO:1904115 0 0 0 PF10046; Q66S13 CHOYP_DSIM_GD10934.1.1 m.5245 sp NATT4_THANI 30.882 136 85 4 4 139 78 204 1.24E-06 49.7 NATT4_THANI reviewed Natterin-4 (EC 3.4.-.-) 0 Thalassophryne nattereri (Niquim) 387 0 GO:0005576; GO:0016787 0 0 0 PF11901; Q6DF67 CHOYP_DDX23.1.1 m.20196 sp ISOC2_XENTR 53.571 168 78 0 24 191 5 172 1.24E-67 209 ISOC2_XENTR reviewed Isochorismatase domain-containing protein 2 isoc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 205 metabolic process [GO:0008152] GO:0003824; GO:0005737; GO:0008152 0 0 0 PF00857; Q6PB70 CHOYP_LOC100882952.1.1 m.56153 sp ANO8_MOUSE 49.177 486 239 4 6 487 37 518 1.24E-151 473 ANO8_MOUSE reviewed Anoctamin-8 (Transmembrane protein 16H) Ano8 Kiaa1623 Tmem16h Mus musculus (Mouse) 1060 chloride transport [GO:0006821] GO:0005229; GO:0005622; GO:0005886; GO:0006821; GO:0016021 0 0 0 PF04547; Q6PDM1 CHOYP_MSL1.1.2 m.14 sp MSL1_MOUSE 31.522 368 181 14 154 469 245 593 1.24E-28 122 MSL1_MOUSE reviewed Male-specific lethal 1 homolog (MSL-1) (Hampin) (Male-specific lethal 1-like 1) (MSL1-like 1) (Male-specific lethal-1 homolog 1) Msl1 Msl1l1 Mus musculus (Mouse) 616 histone H4-K16 acetylation [GO:0043984] GO:0003682; GO:0005654; GO:0043984; GO:0072487 0 0 0 PF16801;PF15275; Q6PFY8 CHOYP_TRI45.16.23 m.41405 sp TRI45_MOUSE 31.343 201 118 5 8 196 129 321 1.24E-15 81.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q75WE7 CHOYP_NEMVEDRAFT_V1G199885.1.1 m.22072 sp VWA5A_RAT 43.871 155 85 2 26 180 1 153 1.24E-35 135 VWA5A_RAT reviewed von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1) Vwa5a Loh11cr2a Masa1 Rattus norvegicus (Rat) 822 0 0 0 0 0 PF08487;PF13768; Q76KX8 CHOYP_LOC100767540.2.2 m.19415 sp ZN534_HUMAN 34.1 261 159 5 386 643 398 648 1.24E-35 146 ZN534_HUMAN reviewed Zinc finger protein 534 (KRAB domain only protein 3) ZNF534 KRBO3 Homo sapiens (Human) 674 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q7JW12 CHOYP_LOC100650138.1.1 m.16879 sp TMX2_DROME 38.492 252 145 4 31 272 18 269 1.24E-62 201 TMX2_DROME reviewed Thioredoxin-related transmembrane protein 2 homolog (Thioredoxin domain-containing protein 14 homolog) CG11007 Drosophila melanogaster (Fruit fly) 271 cell redox homeostasis [GO:0045454] GO:0005623; GO:0016021; GO:0045454 0 0 0 PF00085; Q7KW14 CHOYP_LOC100883165.2.2 m.31736 sp CCDCX_DROME 47.644 191 89 2 684 868 573 758 1.24E-40 167 CCDCX_DROME reviewed Coiled-coil domain-containing protein CG32809 CG32809 Drosophila melanogaster (Fruit fly) 1234 0 0 0 0 0 PF03915; Q8HXM1 CHOYP_ISCW_ISCW015573.1.1 m.9079 sp CSTF2_BOVIN 59.075 281 96 7 27 292 10 286 1.24E-95 301 CSTF2_BOVIN reviewed Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) CSTF2 Bos taurus (Bovine) 572 mRNA polyadenylation [GO:0006378]; pre-mRNA cleavage required for polyadenylation [GO:0098789] GO:0000166; GO:0003729; GO:0005847; GO:0006378; GO:0071920; GO:0098789 0 0 0 PF14327;PF14304;PF00076; Q8ITC3 CHOYP_RS19.8.12 m.42445 sp RS19_ARGIR 75.887 141 33 1 1 141 1 140 1.24E-78 232 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8IW41 CHOYP_LOC100377729.1.1 m.51881 sp MAPK5_HUMAN 49.785 466 208 8 13 461 11 467 1.24E-157 458 MAPK5_HUMAN reviewed MAP kinase-activated protein kinase 5 (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (MAPKAP-K5) (MAPKAPK-5) (MK-5) (MK5) (EC 2.7.11.1) (p38-regulated/activated protein kinase) (PRAK) MAPKAPK5 PRAK Homo sapiens (Human) 473 negative regulation of TOR signaling [GO:0032007]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; Ras protein signal transduction [GO:0007265]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of translation [GO:0006417]; signal transduction [GO:0007165]; stress-induced premature senescence [GO:0090400] GO:0002039; GO:0004674; GO:0004683; GO:0004708; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006417; GO:0007165; GO:0007265; GO:0009931; GO:0018105; GO:0032007; GO:0032212; GO:0046777; GO:0051973; GO:0090400; GO:1901796; GO:1904355 0 0 0 PF00069; Q8IXQ6 CHOYP_LOC100368410.1.2 m.21045 sp PARP9_HUMAN 27.869 183 116 5 498 678 286 454 1.24E-12 75.1 PARP9_HUMAN reviewed Poly [ADP-ribose] polymerase 9 (PARP-9) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) PARP9 BAL BAL1 Homo sapiens (Human) 854 cell migration [GO:0016477]; double-strand break repair [GO:0006302]; regulation of response to interferon-gamma [GO:0060330] GO:0003950; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006302; GO:0016020; GO:0016477; GO:0060330 0 0 0 PF01661; Q8N0N3 CHOYP_LOC373274.1.1 m.29721 sp BGBP_PENMO 50.852 352 156 9 207 554 24 362 1.24E-118 357 BGBP_PENMO reviewed "Beta-1,3-glucan-binding protein (GBP)" 0 Penaeus monodon (Giant tiger prawn) 366 carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087] GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087 0 0 0 PF00722; Q8N2E2 CHOYP_VWDE.7.13 m.32245 sp VWDE_HUMAN 22.051 195 148 3 7 199 850 1042 1.24E-08 59.3 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NDI1 CHOYP_BRAFLDRAFT_65861.1.1 m.24624 sp EHBP1_HUMAN 69.231 182 56 0 2 183 3 184 1.24E-80 288 EHBP1_HUMAN reviewed EH domain-binding protein 1 EHBP1 KIAA0903 NACSIN Homo sapiens (Human) 1231 0 GO:0005737; GO:0005886 0 0 0 PF00307;PF12130;PF10358; Q8VEB2 CHOYP_SAV1.1.1 m.11079 sp SAV1_MOUSE 33.425 365 176 11 1 357 1 306 1.24E-45 163 SAV1_MOUSE reviewed Protein salvador homolog 1 (45 kDa WW domain protein) (mWW45) Sav1 Ww45 Wwp3 Mus musculus (Mouse) 386 hair follicle development [GO:0001942]; hippo signaling [GO:0035329]; intestinal epithelial cell differentiation [GO:0060575]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein stabilization [GO:0050821]; regulation of organ growth [GO:0046620]; regulation of stem cell population maintenance [GO:2000036]; ventricular septum morphogenesis [GO:0060412] GO:0001942; GO:0005634; GO:0005737; GO:0030216; GO:0035329; GO:0043065; GO:0045600; GO:0046620; GO:0050680; GO:0050821; GO:0051091; GO:0060044; GO:0060412; GO:0060487; GO:0060575; GO:2000036 0 0 0 PF00397; Q8VHT8 CHOYP_OCA2.1.1 m.46085 sp TF3A_RAT 46.835 158 79 4 3 157 171 326 1.24E-34 131 TF3A_RAT reviewed Transcription factor IIIA (TFIIIA) Gtf3a Rattus norvegicus (Rat) 363 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0003723; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096; Q91WV7 CHOYP_BRAFLDRAFT_265208.2.7 m.7294 sp SLC31_MOUSE 31.332 683 367 25 18 673 43 650 1.24E-88 294 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q91XB0 CHOYP_contig_031396 m.35854 sp TREX1_MOUSE 27.742 155 94 6 43 185 78 226 1.24E-06 52.4 TREX1_MOUSE reviewed Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III) Trex1 Mus musculus (Mouse) 314 cellular response to interferon-beta [GO:0035458]; DNA metabolic process [GO:0006259] GO:0003690; GO:0003697; GO:0005634; GO:0005789; GO:0005829; GO:0006259; GO:0008296; GO:0008408; GO:0008853; GO:0032405; GO:0032407; GO:0032558; GO:0035458; GO:0042803; GO:0046872 0 0 0 0 Q91YD4 CHOYP_TRPM2.8.12 m.52948 sp TRPM2_MOUSE 25.92 625 339 23 386 921 486 1075 1.24E-37 157 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q96RW7 CHOYP_HMCN1.6.44 m.11266 sp HMCN1_HUMAN 41.7 247 123 6 204 440 4641 4876 1.24E-53 201 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BRZ2 CHOYP_LOC100367973.3.3 m.59253 sp TRI56_HUMAN 23.158 285 178 11 16 283 17 277 1.24E-11 69.3 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9D882 CHOYP_LOC100374742.1.2 m.209 sp CJ035_MOUSE 36 100 45 3 1 90 1 91 1.24E-10 58.2 CJ035_MOUSE reviewed Uncharacterized protein C10orf35 homolog 0 Mus musculus (Mouse) 120 0 GO:0016021 0 0 0 PF15378; Q9EPR4 CHOYP_LOC100486632.1.2 m.47775 sp S23A2_MOUSE 35.739 582 340 6 16 584 62 622 1.24E-112 353 S23A2_MOUSE reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) (SVCT-2) (mSVCT2) (Yolk sac permease-like molecule 2) Slc23a2 Kiaa0238 Svct2 Yspl2 Mus musculus (Mouse) 648 L-ascorbic acid metabolic process [GO:0019852]; L-ascorbic acid transport [GO:0015882]; response to oxidative stress [GO:0006979]; transepithelial L-ascorbic acid transport [GO:0070904] GO:0005737; GO:0005886; GO:0005887; GO:0006979; GO:0008520; GO:0009925; GO:0015229; GO:0015882; GO:0016323; GO:0016324; GO:0019852; GO:0070890; GO:0070904 0 0 0 PF00860; Q9H4K1 CHOYP_LOC100375219.1.1 m.30268 sp RIBC2_HUMAN 47.557 307 160 1 121 427 4 309 1.24E-82 259 RIBC2_HUMAN reviewed RIB43A-like with coiled-coils protein 2 RIBC2 C22orf11 Homo sapiens (Human) 309 0 GO:0005634 0 0 0 PF05914; Q9R0W9 CHOYP_BRAFLDRAFT_205869.1.1 m.45886 sp ACHA6_MOUSE 26.768 396 246 12 4 371 16 395 1.24E-32 131 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9UBU9 CHOYP_NXF1.1.2 m.28017 sp NXF1_HUMAN 41.667 636 329 15 48 665 8 619 1.24E-154 463 NXF1_HUMAN reviewed Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP) NXF1 TAP Homo sapiens (Human) 619 mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA export from nucleus [GO:0006405]; viral process [GO:0016032] GO:0000166; GO:0003727; GO:0003729; GO:0005487; GO:0005634; GO:0005643; GO:0005654; GO:0005829; GO:0006405; GO:0006406; GO:0016032; GO:0016607; GO:0016973; GO:0042405; GO:0044822 0 0 cd00780;cd14342; PF02136;PF09162;PF03943; Q9W636 CHOYP_REQUB.1.1 m.49455 sp REQUB_XENLA 68.889 135 36 2 113 242 232 365 1.24E-61 202 REQUB_XENLA reviewed Zinc finger protein ubi-d4 B (Apoptosis response zinc finger protein B) (Protein requiem B) (xReq B) (Fragment) req-b req2 Xenopus laevis (African clawed frog) 366 "apoptotic process [GO:0006915]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006915; GO:0008270 0 0 0 PF00628;PF14051; B2RPV6 CHOYP_TVAG_497970.5.6 m.47292 sp MMRN1_MOUSE 36.538 104 60 3 351 450 1107 1208 1.25E-08 61.2 MMRN1_MOUSE reviewed Multimerin-1 Mmrn1 Mus musculus (Mouse) 1210 blood coagulation [GO:0007596] GO:0005509; GO:0005576; GO:0007596 0 0 0 PF00386;PF00008;PF07546; B4DXR9 CHOYP_ZNF99.3.3 m.46580 sp ZN732_HUMAN 38.197 233 125 6 1 227 308 527 1.25E-42 155 ZN732_HUMAN reviewed Zinc finger protein 732 ZNF732 Homo sapiens (Human) 585 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; B5X601 CHOYP_SWI5.2.2 m.41455 sp SWI5_SALSA 42.857 98 51 1 15 112 46 138 1.25E-22 88.6 SWI5_SALSA reviewed DNA repair protein SWI5 homolog (Protein SAE3 homolog) swi5 sae3 Salmo salar (Atlantic salmon) 138 double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0005634; GO:0032798 0 0 0 PF07061; C9JJ37 CHOYP_BRAFLDRAFT_208819.1.1 m.61942 sp BTBDJ_HUMAN 38.462 286 170 3 6 290 7 287 1.25E-65 210 BTBDJ_HUMAN reviewed BTB/POZ domain-containing protein 19 BTBD19 Homo sapiens (Human) 291 0 0 0 0 0 PF07707;PF00651; C9JJ37 CHOYP_LOC100367437.1.1 m.25153 sp BTBDJ_HUMAN 38.462 286 170 3 6 290 7 287 1.25E-65 210 BTBDJ_HUMAN reviewed BTB/POZ domain-containing protein 19 BTBD19 Homo sapiens (Human) 291 0 0 0 0 0 PF07707;PF00651; E1BD59 CHOYP_LOC100376608.4.4 m.59480 sp TRI56_BOVIN 27 200 140 4 1 195 160 358 1.25E-13 77 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; E9Q6J5 CHOYP_LOC100373080.2.6 m.5293 sp BD1L1_MOUSE 54.808 104 47 0 12 115 50 153 1.25E-33 146 BD1L1_MOUSE reviewed Biorientation of chromosomes in cell division protein 1-like 1 Bod1l Kiaa1327 Mus musculus (Mouse) 3032 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] GO:0003677; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0031297 0 0 0 0 O14867 CHOYP_LOC100575377.3.10 m.18365 sp BACH1_HUMAN 28.205 117 84 0 7 123 11 127 1.25E-09 65.1 BACH1_HUMAN reviewed Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) 736 "DNA repair [GO:0006281]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]" GO:0000083; GO:0000117; GO:0000122; GO:0000980; GO:0001078; GO:0001205; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006281; GO:0006355; GO:0016567; GO:0020037; GO:0031463; GO:0061418 0 0 0 PF00651;PF03131; O35075 CHOYP_LOC100640206.1.1 m.48266 sp DSCR3_MOUSE 64.983 297 101 3 2 298 3 296 1.25E-148 421 DSCR3_MOUSE reviewed Down syndrome critical region protein 3 homolog (Down syndrome critical region protein A homolog) Dscr3 Dcra Dscra Mus musculus (Mouse) 297 intracellular protein transport [GO:0006886] GO:0005634; GO:0005768; GO:0006886; GO:0008565 0 0 0 PF03643; O70277 CHOYP_BRAFLDRAFT_87279.5.10 m.32939 sp TRIM3_RAT 26.667 150 98 5 127 269 599 743 1.25E-07 56.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_LOC100373444.47.79 m.39431 sp TRIM3_HUMAN 22.615 283 168 13 299 554 486 744 1.25E-07 58.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02707 CHOYP_LOC101237396.1.1 m.20437 sp LECH_CHICK 26.19 126 84 3 196 317 85 205 1.25E-06 52 LECH_CHICK reviewed Hepatic lectin 0 Gallus gallus (Chicken) 207 endocytosis [GO:0006897] GO:0006897; GO:0016021; GO:0030246 0 0 0 PF00059; P07207 CHOYP_NOTCH.5.6 m.51094 sp NOTCH_DROME 36.031 1038 559 18 85 1027 424 1451 1.25E-180 599 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P0CB97 CHOYP_LOC100373694.1.1 m.11753 sp NDUS8_PONAB 76.882 186 43 0 38 223 25 210 1.25E-103 301 NDUS8_PONAB reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit)" NDUFS8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 210 mitochondrial respiratory chain complex I assembly [GO:0032981]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005747; GO:0006979; GO:0008137; GO:0032981; GO:0046872; GO:0051539 0 0 0 PF12838; P13590 CHOYP_DPR2.1.1 m.36510 sp NCAM1_CHICK 25.381 197 116 7 44 239 222 388 1.25E-07 56.6 NCAM1_CHICK reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) 1091 cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167] GO:0005886; GO:0007155; GO:0016021; GO:0030198; GO:0031175; GO:0048167 0 0 0 PF00041;PF07679; P13670 CHOYP_NEMVEDRAFT_V1G201552.4.6 m.22239 sp CHB_VIBHA 34.857 525 279 17 2 501 25 511 1.25E-87 290 CHB_VIBHA reviewed "N,N'-diacetylchitobiase (Chitobiase) (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase)" chb Vibrio harveyi (Beneckea harveyi) 883 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0009279; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; P14381 CHOYP_BRAFLDRAFT_199990.2.3 m.64105 sp YTX2_XENLA 28.148 270 178 5 4 264 3 265 1.25E-24 107 YTX2_XENLA reviewed Transposon TX1 uncharacterized 149 kDa protein (ORF 2) 0 Xenopus laevis (African clawed frog) 1308 0 0 0 0 0 PF03372;PF00078; P14410 CHOYP_SUIS.1.2 m.3688 sp SUIS_HUMAN 42.51 494 258 9 1 491 422 892 1.25E-124 403 SUIS_HUMAN reviewed "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]" SI Homo sapiens (Human) 1827 carbohydrate metabolic process [GO:0005975]; polysaccharide digestion [GO:0044245] GO:0004558; GO:0004574; GO:0004575; GO:0005794; GO:0005886; GO:0005903; GO:0005975; GO:0016021; GO:0016324; GO:0030246; GO:0044245; GO:0070062 0 0 cd00111; PF01055;PF16863;PF00088; P16157 CHOYP_ANK1.8.8 m.66656 sp ANK1_HUMAN 35.048 311 184 2 16 326 207 499 1.25E-42 160 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18426 CHOYP_NEMVEDRAFT_V1G179696.1.1 m.40556 sp SCR11_NOTSL 40.299 201 117 3 1 199 1 200 1.25E-45 152 SCR11_NOTSL reviewed S-crystallin SL11 (Major lens polypeptide) 0 Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei) 205 0 GO:0005212 0 0 0 PF14497;PF02798; P20905 CHOYP_5HT1R.1.1 m.61492 sp 5HT1R_DROME 44.472 398 206 5 47 436 159 549 1.25E-101 318 5HT1R_DROME reviewed 5-hydroxytryptamine receptor 1 (5-HT receptor) (5HT-dro) (Serotonin receptor 1) 5-HT7 5HT-R1 CG12073 Drosophila melanogaster (Fruit fly) 564 "adenylate cyclase-activating serotonin receptor signaling pathway [GO:0007192]; courtship behavior [GO:0007619]; female mating behavior [GO:0060180]; male courtship behavior, orientation prior to leg tapping and wing vibration [GO:0016543]; male courtship behavior, proboscis-mediated licking [GO:0016546]; male courtship behavior, veined wing vibration [GO:0016545]; male mating behavior [GO:0060179]; serotonin receptor signaling pathway [GO:0007210]" GO:0004952; GO:0004993; GO:0005887; GO:0007192; GO:0007210; GO:0007619; GO:0008227; GO:0016021; GO:0016543; GO:0016545; GO:0016546; GO:0060179; GO:0060180 0 0 0 PF00001; P21522 CHOYP_RN185.2.2 m.65169 sp ROA1_SCHAM 52.899 138 65 0 1 138 49 186 1.25E-44 157 ROA1_SCHAM reviewed "Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog" HNRNP Schistocerca americana (American grasshopper) 342 0 GO:0000166; GO:0003723; GO:0005634; GO:0030529 0 0 0 PF00076; P23606 CHOYP_NEMVEDRAFT_V1G194582.2.2 m.40726 sp TGM1_RAT 51.78 309 144 4 1 306 251 557 1.25E-100 318 TGM1_RAT reviewed Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) Tgm1 Rattus norvegicus (Rat) 824 keratinization [GO:0031424]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838] GO:0003810; GO:0010838; GO:0018149; GO:0031224; GO:0031424; GO:0045787; GO:0046872; GO:0070062 0 0 0 PF00927;PF01841;PF00868; P24367 CHOYP_BM1_24035.1.1 m.40152 sp PPIB_CHICK 62.581 155 54 2 66 220 46 196 1.25E-63 199 PPIB_CHICK reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207 chaperone-mediated protein folding [GO:0061077]; protein peptidyl-prolyl isomerization [GO:0000413] GO:0000413; GO:0003755; GO:0005788; GO:0032403; GO:0032991; GO:0042277; GO:0042470; GO:0061077 0 0 0 PF00160; P27473 CHOYP_LOC100377780.6.11 m.46713 sp IFI44_PANTR 34.241 257 167 2 268 523 168 423 1.25E-42 160 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P47747 CHOYP_contig_001016 m.1047 sp HRH2_CAVPO 34.783 92 55 2 28 119 220 306 1.25E-09 57.4 HRH2_CAVPO reviewed Histamine H2 receptor (H2R) (HH2R) (Gastric receptor I) HRH2 Cavia porcellus (Guinea pig) 359 gastric acid secretion [GO:0001696]; positive regulation of vasoconstriction [GO:0045907] GO:0001696; GO:0004969; GO:0005886; GO:0016021; GO:0045907 0 0 0 PF00001; P50613 CHOYP_LOC100748883.1.1 m.58848 sp CDK7_HUMAN 67.638 343 105 2 10 348 6 346 1.25E-173 489 CDK7_HUMAN reviewed Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) CDK7 CAK CAK1 CDKN7 MO15 STK1 Homo sapiens (Human) 346 "7-methylguanosine mRNA capping [GO:0006370]; androgen receptor signaling pathway [GO:0030521]; cell cycle arrest [GO:0007050]; cell division [GO:0051301]; cell proliferation [GO:0008283]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; termination of RNA polymerase I transcription [GO:0006363]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription initiation from RNA polymerase I promoter [GO:0006361]" GO:0000079; GO:0000082; GO:0000086; GO:0003713; GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005654; GO:0005675; GO:0005737; GO:0005739; GO:0006283; GO:0006294; GO:0006361; GO:0006362; GO:0006363; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0007050; GO:0008022; GO:0008094; GO:0008283; GO:0008353; GO:0016301; GO:0030521; GO:0042795; GO:0045893; GO:0045944; GO:0048471; GO:0050681; GO:0051301 0 0 0 PF00069; P61277 CHOYP_LOC575203.1.6 m.4499 sp CATK_MACMU 45.385 130 67 3 7 133 6 134 1.25E-24 100 CATK_MACMU reviewed Cathepsin K (EC 3.4.22.38) CTSK Macaca mulatta (Rhesus macaque) 329 collagen catabolic process [GO:0030574]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of mitophagy [GO:1903146] GO:0004197; GO:0005615; GO:0005764; GO:0030574; GO:0043394; GO:0051603; GO:1903146; GO:1903955 0 0 0 PF08246;PF00112; P82125 CHOYP_ALDR.1.1 m.50075 sp AKCL2_PIG 53.268 306 131 4 18 319 4 301 1.25E-111 328 AKCL2_PIG reviewed "1,5-anhydro-D-fructose reductase (AF reductase) (EC 1.1.1.263) (Aldo-keto reductase family 1 member C-like protein 2) (Aldo-keto reductase family 1 member CL2) (Aldo-keto reductase family 1 member E2)" AKR1E2 AKR1CL2 Sus scrofa (Pig) 301 0 GO:0050571 0 0 cd06660; PF00248; P83038 CHOYP_PHUM_PHUM292420.1.1 m.2175 sp HDAC4_CHICK 45.625 160 60 8 79 220 93 243 1.25E-22 106 HDAC4_CHICK reviewed Histone deacetylase 4 (HD4) (EC 3.5.1.98) HDAC4 Gallus gallus (Chicken) 1080 "B cell activation [GO:0042113]; B cell differentiation [GO:0030183]; chromatin modification [GO:0016568]; chromatin organization [GO:0006325]; inflammatory response [GO:0006954]; negative regulation of striated muscle tissue development [GO:0045843]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0004407; GO:0006325; GO:0006351; GO:0006954; GO:0007399; GO:0008134; GO:0016568; GO:0030183; GO:0032041; GO:0042113; GO:0045843; GO:0045892; GO:0046872 0 0 0 PF12203;PF00850; P83425 CHOYP_LOC100698726.6.8 m.29032 sp HIP_MYTED 27.273 176 113 6 30 197 45 213 1.25E-09 58.9 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q02645 CHOYP_ADD.3.5 m.17639 sp HTS_DROME 44.154 650 304 14 33 643 26 655 1.25E-175 540 HTS_DROME reviewed Protein hu-li tai shao (Adducin-like protein) hts CG9325 Drosophila melanogaster (Fruit fly) 1156 "actin filament bundle organization [GO:0061572]; adult somatic muscle development [GO:0007527]; axon guidance [GO:0007411]; centrosome organization [GO:0051297]; cystoblast division [GO:0007282]; female germ-line cyst formation [GO:0048135]; female germline ring canal formation, actin assembly [GO:0008302]; fusome organization [GO:0045478]; germarium-derived oocyte fate determination [GO:0007294]; germ-line cyst formation [GO:0048134]; locomotion involved in locomotory behavior [GO:0031987]; meiotic spindle organization [GO:0000212]; neuron cellular homeostasis [GO:0070050]; oogenesis [GO:0048477]; ovarian fusome organization [GO:0030723]; photoreceptor cell axon guidance [GO:0072499]; sarcomere organization [GO:0045214]; spectrosome organization [GO:0030721]; testicular fusome organization [GO:0030724]" GO:0000212; GO:0005737; GO:0005811; GO:0005856; GO:0005886; GO:0007282; GO:0007294; GO:0007411; GO:0007527; GO:0008302; GO:0016328; GO:0030721; GO:0030723; GO:0030724; GO:0031987; GO:0035183; GO:0045169; GO:0045170; GO:0045172; GO:0045214; GO:0045478; GO:0048134; GO:0048135; GO:0048477; GO:0051297; GO:0061572; GO:0070050; GO:0072499 0 0 0 PF00596; Q02763 CHOYP_TIE2.2.6 m.35595 sp TIE2_HUMAN 27.235 481 298 14 1069 1523 642 1096 1.25E-43 177 TIE2_HUMAN reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 Homo sapiens (Human) 1124 angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; leukocyte migration [GO:0050900]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; organ regeneration [GO:0031100]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000165; GO:0001525; GO:0001666; GO:0001934; GO:0001935; GO:0001938; GO:0001958; GO:0002040; GO:0004672; GO:0004713; GO:0004714; GO:0004872; GO:0005088; GO:0005524; GO:0005576; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007165; GO:0007169; GO:0007267; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016323; GO:0016324; GO:0016525; GO:0018108; GO:0031100; GO:0032878; GO:0034446; GO:0043066; GO:0043114; GO:0043434; GO:0043552; GO:0043627; GO:0045121; GO:0045766; GO:0046777; GO:0048014; GO:0050728; GO:0050900; GO:0051259; GO:0051591; GO:0051894; GO:0051897; GO:0060216; GO:0060347; GO:0070374; GO:0072012; GO:1902533; GO:2000251; GO:2000351; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q03484 CHOYP_GPTC4.1.2 m.20384 sp CEBPD_RAT 49.438 89 40 3 251 336 165 251 1.25E-15 79.3 CEBPD_RAT reviewed CCAAT/enhancer-binding protein delta (C/EBP delta) (Transcription factor CELF) Cebpd Celf Rattus norvegicus (Rat) 268 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0005634; GO:0043565; GO:0045944 0 0 0 PF07716; Q05A80 CHOYP_LOC101066959.1.2 m.2472 sp CAPR2_MOUSE 30.286 175 107 7 16 187 862 1024 1.25E-08 57.4 CAPR2_MOUSE reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) 1031 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q09221 CHOYP_LOC100369190.1.1 m.57533 sp CPNA2_CAEEL 55.556 279 112 5 45 314 7424 7699 1.25E-92 304 CPNA2_CAEEL reviewed Copine family protein 2 cpna-2 B0228.4 Caenorhabditis elegans 7705 0 0 0 0 0 PF07002; Q09654 CHOYP_LOC100376215.2.19 m.13220 sp TRI23_CAEEL 30.097 103 64 4 24 120 119 219 1.25E-06 53.1 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q1LY46 CHOYP_LOC100563554.1.1 m.49953 sp LETM1_DANRE 34.161 685 339 12 155 834 155 732 1.25E-106 349 LETM1_DANRE reviewed "LETM1 and EF-hand domain-containing protein 1, mitochondrial (Leucine zipper-EF-hand-containing transmembrane protein 1)" letm1 si:ch211-195n12.1 si:rp71-77d7.1 Danio rerio (Zebrafish) (Brachydanio rerio) 757 0 GO:0005509; GO:0005743; GO:0016021; GO:0043022 0 0 0 PF07766; Q20191 CHOYP_LOC100377601.2.2 m.64411 sp NAS13_CAEEL 33.631 336 203 8 113 431 118 450 1.25E-51 184 NAS13_CAEEL reviewed Zinc metalloproteinase nas-13 (EC 3.4.24.21) (Nematode astacin 13) nas-13 F39D8.4 Caenorhabditis elegans 450 0 GO:0004222; GO:0005576; GO:0008270 0 0 0 PF01400;PF01549; Q2HJ41 CHOYP_PRP18.1.1 m.2214 sp PRP18_BOVIN 51.917 339 159 3 6 342 3 339 1.25E-118 349 PRP18_BOVIN reviewed Pre-mRNA-splicing factor 18 (PRP18 homolog) PRPF18 Bos taurus (Bovine) 342 generation of catalytic spliceosome for second transesterification step [GO:0000350]; nuclear retention of unspliced pre-mRNA at the site of transcription [GO:0071048] GO:0000350; GO:0005682; GO:0016607; GO:0046540; GO:0071021; GO:0071048 0 0 0 PF02840;PF08799; Q4LDE5 CHOYP_LOC100906063.1.3 m.20630 sp SVEP1_HUMAN 33.333 135 78 4 441 574 2345 2468 1.25E-13 78.2 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q56Y42 CHOYP_BRAFLDRAFT_77607.1.1 m.7987 sp PLR1_ARATH 37.5 112 49 5 38 149 257 347 1.25E-08 56.6 PLR1_ARATH reviewed "Pyridoxal reductase, chloroplastic (EC 1.1.1.65)" PLR1 At5g53580 MNC6.12 Arabidopsis thaliana (Mouse-ear cress) 365 pyridoxal 5'-phosphate salvage [GO:0009443]; pyridoxal biosynthetic process [GO:0042821]; vitamin B6 catabolic process [GO:0042820] GO:0009443; GO:0009507; GO:0042820; GO:0042821; GO:0050236; GO:0070402 PATHWAY: Cofactor degradation; B6 vitamer degradation; pyridoxal from pyridoxine (dehydrogenase route): step 1/1. 0 cd06660; PF00248; Q58DT4 CHOYP_contig_007115 m.8183 sp P5CR1_BOVIN 48.913 276 136 2 1 271 1 276 1.25E-83 258 P5CR1_BOVIN reviewed "Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)" PYCR1 Bos taurus (Bovine) 320 cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; proline biosynthetic process [GO:0006561]; regulation of mitochondrial membrane potential [GO:0051881] GO:0004735; GO:0005739; GO:0006561; GO:0034599; GO:0051881; GO:0055129; GO:1903206 PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. 0 0 PF03807;PF14748; Q5RCM6 CHOYP_SOCS6.1.1 m.36183 sp SOCS6_PONAB 71.856 167 47 0 222 388 369 535 1.25E-80 260 SOCS6_PONAB reviewed Suppressor of cytokine signaling 6 (SOCS-6) SOCS6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 535 intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell activation [GO:0050868]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008] GO:0001772; GO:0005622; GO:0009968; GO:0010498; GO:0016567; GO:0035556; GO:0040008; GO:0050868 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00017;PF07525; Q5UR67 CHOYP_contig_005295 m.6030 sp RIBX_MIMIV 49.425 87 44 0 1 87 79 165 1.25E-18 80.9 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q66I21 CHOYP_CTL2.1.2 m.3859 sp AL8A1_DANRE 63.755 229 83 0 5 233 8 236 1.25E-105 316 AL8A1_DANRE reviewed Aldehyde dehydrogenase family 8 member A1 (EC 1.2.1.-) aldh8a1 Danio rerio (Zebrafish) (Brachydanio rerio) 487 liver development [GO:0001889] GO:0001758; GO:0001889; GO:0004029; GO:0005737 0 0 0 PF00171; Q6DIB5 CHOYP_contig_033588 m.38219 sp MEG10_MOUSE 37.891 512 272 24 193 690 185 664 1.25E-71 255 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6GQD3 CHOYP_RB24A.1.1 m.56425 sp RB24A_XENLA 72.8 125 28 3 6 124 4 128 1.25E-57 181 RB24A_XENLA reviewed RNA-binding protein 24-A (RNA-binding motif protein 24-A) (RRM domain-containing protein SEB-4) (SEB-4) (Xseb-4) rbm24-a Xenopus laevis (African clawed frog) 225 cell differentiation [GO:0030154]; regulation of mRNA stability [GO:0043488]; regulation of myotube differentiation [GO:0010830] GO:0000166; GO:0003730; GO:0005634; GO:0005737; GO:0010830; GO:0030154; GO:0043488 0 0 0 PF00076; Q6TLF6 CHOYP_LOC576326.1.1 m.49857 sp RGN_DANRE 40.594 303 167 5 1 301 4 295 1.25E-72 228 RGN_DANRE reviewed Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) rgn zgc:92078 Danio rerio (Zebrafish) (Brachydanio rerio) 295 cellular calcium ion homeostasis [GO:0006874]; L-ascorbic acid biosynthetic process [GO:0019853]; positive regulation of ATPase activity [GO:0032781]; regulation of calcium-mediated signaling [GO:0050848] GO:0004341; GO:0005509; GO:0005634; GO:0005737; GO:0006874; GO:0008270; GO:0019853; GO:0030234; GO:0032781; GO:0050848 PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. 0 0 PF08450; Q7PD79 CHOYP_GNAS.2.3 m.41334 sp GNAS_ANOGA 41.452 427 204 7 6 430 1 383 1.25E-109 331 GNAS_ANOGA reviewed Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) G-s-alpha-60A AGAP012095 Anopheles gambiae (African malaria mosquito) 383 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; sensory perception of chemical stimulus [GO:0007606]; sensory perception of smell [GO:0007608] GO:0003924; GO:0004871; GO:0005525; GO:0007191; GO:0007606; GO:0007608; GO:0046872 0 0 0 PF00503; Q7YU24 CHOYP_LOC100370896.1.4 m.18388 sp MARF_DROME 25 292 166 11 32 298 83 346 1.25E-11 68.9 MARF_DROME reviewed Transmembrane GTPase Marf (EC 3.6.5.-) (Mitochondrial assembly regulatory factor) (Mitofusin) Marf dmfn CG3869 Drosophila melanogaster (Fruit fly) 810 adult locomotory behavior [GO:0008344]; axonal transport of mitochondrion [GO:0019896]; ecdysone biosynthetic process [GO:0006697]; endoplasmic reticulum organization [GO:0007029]; lipid particle organization [GO:0034389]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; positive regulation of mitochondrial fusion [GO:0010636]; regulation of mitochondrial fission [GO:0090140]; response to endoplasmic reticulum stress [GO:0034976] GO:0003924; GO:0005525; GO:0005740; GO:0005741; GO:0006697; GO:0007005; GO:0007029; GO:0008053; GO:0008344; GO:0010636; GO:0016021; GO:0019896; GO:0034389; GO:0034976; GO:0070584; GO:0090140; GO:1904115 0 0 0 PF00350;PF04799; Q7ZWM6 CHOYP_OLA1.1.2 m.6008 sp OLA1_XENLA 79.348 92 19 0 24 115 1 92 1.25E-48 162 OLA1_XENLA reviewed Obg-like ATPase 1 ola1 Xenopus laevis (African clawed frog) 396 0 GO:0005524; GO:0005525; GO:0005730; GO:0005737; GO:0016887; GO:0043022; GO:0043023; GO:0046872 0 0 0 PF01926;PF06071; Q7ZYB4 CHOYP_PAIP1.1.1 m.23425 sp PAIP1_XENLA 32.178 404 213 12 65 463 106 453 1.25E-47 173 PAIP1_XENLA reviewed Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Paip1 protein) (Poly(A)-binding protein-interacting protein 1) (XlPaip1) paip1 Xenopus laevis (African clawed frog) 463 0 GO:0003723; GO:0005737; GO:0008494 0 0 0 PF02854; Q812A5 CHOYP_LOC101172297.1.1 m.41854 sp PRR5_MOUSE 37.387 222 127 3 44 265 10 219 1.25E-42 155 PRR5_MOUSE reviewed Proline-rich protein 5 (Protein observed with Rictor-1) (Protor-1) Prr5 Protor1 Mus musculus (Mouse) 387 actin cytoskeleton organization [GO:0030036]; cell cycle [GO:0007049]; positive regulation of cell migration [GO:0030335]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein phosphorylation [GO:0001934] GO:0001934; GO:0005096; GO:0007049; GO:0014068; GO:0030036; GO:0030335; GO:0031932 0 0 0 PF08539; Q8BX70 CHOYP_LOC100649375.1.1 m.21223 sp VP13C_MOUSE 26.012 173 100 6 2 163 2525 2680 1.25E-07 53.5 VP13C_MOUSE reviewed Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) 3748 mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0005741; GO:0005829; GO:0006623; GO:0007005; GO:0019898; GO:0045053; GO:0070062; GO:1905090 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q8BZ25 CHOYP_TVAG_451090.12.13 m.64652 sp ANKK1_MOUSE 35.802 243 156 0 5 247 386 628 1.25E-40 151 ANKK1_MOUSE reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) 745 0 GO:0004674; GO:0005524 0 0 0 PF00023;PF12796;PF07714; Q8C0J6 CHOYP_LOC100762040.1.1 m.58147 sp SWAHC_MOUSE 46.774 124 61 1 22 140 246 369 1.25E-35 132 SWAHC_MOUSE reviewed Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) Sowahc Ankrd57 Mus musculus (Mouse) 512 0 0 0 0 0 PF12796; Q8JHV9 CHOYP_TIAP2.2.13 m.28850 sp BIR7A_XENLA 30.282 284 164 8 28 295 133 398 1.25E-38 143 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8MIB8 CHOYP_BRAFLDRAFT_123978.1.1 m.39945 sp TF2LX_PONPY 44.776 67 37 0 1052 1118 50 116 1.25E-13 75.1 TF2LX_PONPY reviewed "Homeobox protein TGIF2LX (TGF-beta-induced transcription factor 2-like protein) (TGFB-induced factor 2-like protein, X-linked) (TGIF-like on the X)" TGIF2LX TGIFLX Pongo pygmaeus (Bornean orangutan) 241 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF05920; Q8N5S9 CHOYP_CAMKK1.1.1 m.25675 sp KKCC1_HUMAN 61.183 389 134 3 1 373 109 496 1.25E-163 471 KKCC1_HUMAN reviewed Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) CAMKK1 CAMKKA Homo sapiens (Human) 505 activation of protein kinase activity [GO:0032147] GO:0004683; GO:0005524; GO:0005634; GO:0005829; GO:0032147 0 0 0 PF00069; Q8TCF1 CHOYP_ZFAND1.1.1 m.13818 sp ZFAN1_HUMAN 45.055 182 95 3 3 181 77 256 1.25E-48 162 ZFAN1_HUMAN reviewed AN1-type zinc finger protein 1 ZFAND1 Homo sapiens (Human) 268 0 GO:0008270 0 0 0 PF01428; Q8TD35 CHOYP_LOC100369389.1.1 m.11887 sp LKAM1_HUMAN 34.375 160 92 3 11 164 33 185 1.25E-12 66.2 LKAM1_HUMAN reviewed Protein LKAAEAR1 (LKAAEAR motif-containing protein 1) LKAAEAR1 C20orf201 Homo sapiens (Human) 194 0 0 0 0 0 PF15478; Q8VCA8 CHOYP_LOC100373892.2.2 m.55838 sp SCRN2_MOUSE 45.585 419 217 7 3 417 13 424 1.25E-114 345 SCRN2_MOUSE reviewed Secernin-2 Scrn2 Mus musculus (Mouse) 425 exocytosis [GO:0006887] GO:0006887; GO:0016805; GO:0070062 0 0 0 PF03577; Q90YV7 CHOYP_LOC100213722.1.1 m.22026 sp RL11_ICTPU 78.286 175 38 0 6 180 1 175 1.25E-103 298 RL11_ICTPU reviewed 60S ribosomal protein L11 rpl11 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 178 protein localization to nucleus [GO:0034504]; translation [GO:0006412] GO:0003735; GO:0005730; GO:0005840; GO:0006412; GO:0019843; GO:0034504 0 0 0 PF00281;PF00673; Q91584 CHOYP_LOC100533384.2.5 m.31219 sp ELAV3_XENLA 48.366 153 79 0 30 182 31 183 1.25E-47 161 ELAV3_XENLA reviewed ELAV-like protein 3 (Protein ElrC) elavl3 elrC Xenopus laevis (African clawed frog) 348 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0000166; GO:0003723; GO:0007399; GO:0030154; GO:0030529 0 0 0 PF00076; Q923D5 CHOYP_WBP11.1.1 m.12849 sp WBP11_MOUSE 62.57 179 60 3 1 178 1 173 1.25E-61 218 WBP11_MOUSE reviewed WW domain-binding protein 11 (WBP-11) (Splicing factor that interacts with PQBP-1 and PP1) Wbp11 Sipp1 Mus musculus (Mouse) 641 "mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]" GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006364; GO:0008380; GO:0008599; GO:0016607; GO:0043231; GO:0044822; GO:0045292; GO:0050699; GO:1903146; GO:1903955 0 0 0 PF09429; Q95NR9 CHOYP_CALM.44.50 m.56751 sp CALM_METSE 81.379 145 27 0 8 152 4 148 1.25E-83 245 CALM_METSE reviewed Calmodulin (CaM) 0 Metridium senile (Brown sea anemone) (Frilled sea anemone) 149 0 GO:0005509 0 0 0 PF13499; Q96KG7 CHOYP_MEG11.25.25 m.65690 sp MEG10_HUMAN 39.073 151 81 7 176 323 185 327 1.25E-13 76.3 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q99315 CHOYP_LOC578054.2.7 m.13787 sp YG31B_YEAST 26.905 420 282 11 458 863 1040 1448 1.25E-35 150 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q99KL7 CHOYP_LOC100366300.1.1 m.8591 sp RAB28_MOUSE 66.667 222 73 1 1 222 1 221 1.25E-110 319 RAB28_MOUSE reviewed Ras-related protein Rab-28 Rab28 Mus musculus (Mouse) 221 small GTPase mediated signal transduction [GO:0007264]; toxin transport [GO:1901998] GO:0005525; GO:0005737; GO:0005886; GO:0007264; GO:0019003; GO:0035253; GO:0036064; GO:1901998 0 0 0 PF00071; Q99N28 CHOYP_CEAM5.1.6 m.21966 sp CADM3_MOUSE 26.761 284 183 11 53 333 38 299 1.25E-13 76.3 CADM3_MOUSE reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (TSLC1-like protein 1) Cadm3 Igsf4b Necl1 Syncam3 Tsll1 Mus musculus (Mouse) 396 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein localization [GO:0008104] GO:0004872; GO:0005102; GO:0005887; GO:0005911; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0008104; GO:0042803; GO:0050839 0 0 0 PF08205;PF07679; Q99NH0 CHOYP_LOC100641396.8.27 m.33045 sp ANR17_MOUSE 33.333 504 292 16 80 566 218 694 1.25E-48 186 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9H8W5 CHOYP_BRAFLDRAFT_63830.2.2 m.58799 sp TRI45_HUMAN 27.528 178 109 6 52 224 133 295 1.25E-07 56.6 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9HAZ2 CHOYP_LOC100518275.1.1 m.9881 sp PRD16_HUMAN 40.325 615 264 20 1 524 1 603 1.25E-114 384 PRD16_HUMAN reviewed PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1) PRDM16 KIAA1675 MEL1 PFM13 Homo sapiens (Human) 1276 "brown fat cell differentiation [GO:0050873]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neurogenesis [GO:0022008]; palate development [GO:0060021]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cellular respiration [GO:0043457]; somatic stem cell population maintenance [GO:0035019]; tongue development [GO:0043586]; transcription, DNA-templated [GO:0006351]; white fat cell differentiation [GO:0050872]" GO:0000122; GO:0003713; GO:0005634; GO:0005829; GO:0006351; GO:0017053; GO:0018024; GO:0022008; GO:0030512; GO:0030853; GO:0033613; GO:0035019; GO:0043457; GO:0043565; GO:0043586; GO:0045892; GO:0045893; GO:0046872; GO:0050872; GO:0050873; GO:0060021; GO:0090336 0 0 0 PF00096;PF13912; Q9JMJ2 CHOYP_FBXW4.1.1 m.9341 sp FBXW4_MOUSE 36.869 396 212 9 23 397 29 407 1.25E-70 230 FBXW4_MOUSE reviewed F-box/WD repeat-containing protein 4 (F-box and WD-40 domain-containing protein 4) (Protein hagoromo) Fbxw4 Fbw4 Mus musculus (Mouse) 410 cartilage development [GO:0051216]; embryonic digit morphogenesis [GO:0042733]; limb development [GO:0060173]; positive regulation of mesenchymal cell proliferation [GO:0002053]; Wnt signaling pathway [GO:0016055] GO:0002053; GO:0016055; GO:0042733; GO:0051216; GO:0060173 0 0 0 PF12937;PF00400; Q9R085 CHOYP_UBP15.1.4 m.37674 sp UBP15_RAT 49.541 109 55 0 1 109 122 230 1.25E-26 115 UBP15_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin carboxyl-terminal hydrolase of 109 kDa) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) Usp15 ubp109 Rattus norvegicus (Rat) 952 BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; protein deubiquitination [GO:0016579]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004197; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0007179; GO:0016579; GO:0030509; GO:0035520; GO:0035616; GO:0060389 0 0 0 PF06337;PF14836;PF00443;PF14533; Q9SZJ2 CHOYP_LOC100367312.1.13 m.1239 sp GRDP2_ARATH 39.576 283 153 5 7 275 17 295 1.25E-55 206 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; Q9TU19 CHOYP_TPC2.1.2 m.19379 sp NPHP1_CANLF 39.922 516 303 4 78 593 50 558 1.25E-132 402 NPHP1_CANLF reviewed Nephrocystin-1 (Fragment) NPHP1 NPH1 Canis lupus familiaris (Dog) (Canis familiaris) 565 cell differentiation [GO:0030154]; cell projection organization [GO:0030030]; spermatogenesis [GO:0007283] GO:0005737; GO:0005856; GO:0005911; GO:0005912; GO:0005923; GO:0005929; GO:0007283; GO:0030030; GO:0030154 0 0 0 PF00018; Q9TUP7 CHOYP_LOC100120994.1.1 m.54109 sp OX2R_CANLF 38.318 428 221 9 47 431 1 428 1.25E-92 289 OX2R_CANLF reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Canis lupus familiaris (Dog) (Canis familiaris) 444 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; Q9UIH9 CHOYP_KLF15.1.1 m.3997 sp KLF15_HUMAN 55.063 158 65 3 167 318 247 404 1.25E-49 173 KLF15_HUMAN reviewed Krueppel-like factor 15 (Kidney-enriched krueppel-like factor) KLF15 KKLF Homo sapiens (Human) 416 cardiac muscle hypertrophy in response to stress [GO:0014898]; cellular response to peptide [GO:1901653]; glial cell differentiation [GO:0010001]; glomerular visceral epithelial cell differentiation [GO:0072112]; glucose transport [GO:0015758]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001077; GO:0005634; GO:0010001; GO:0014898; GO:0015758; GO:0044212; GO:0045944; GO:0046872; GO:0072112; GO:1901653; GO:2000757 0 0 0 PF00096; Q9VCA8 CHOYP_LOC583072.11.25 m.45708 sp ANKHM_DROME 34.286 420 260 12 882 1287 619 1036 1.25E-44 181 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9XSC1 CHOYP_ISCW_ISCW003981.1.1 m.36311 sp SFRP5_BOVIN 33.333 159 97 6 4 155 140 296 1.25E-20 92 SFRP5_BOVIN reviewed Secreted frizzled-related protein 5 (sFRP-5) SFRP5 Bos taurus (Bovine) 315 canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catenin import into nucleus [GO:0035414]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis [GO:2000057]; non-canonical Wnt signaling pathway [GO:0035567] GO:0004930; GO:0005576; GO:0007275; GO:0008285; GO:0016021; GO:0017147; GO:0030154; GO:0030178; GO:0035414; GO:0035567; GO:0042813; GO:0043433; GO:0051898; GO:0060070; GO:0090090; GO:2000057 0 0 0 PF01392;PF01759; Q9Y4F5 CHOYP_SRAP.3.18 m.21215 sp C170B_HUMAN 50 96 48 0 37 132 6 101 1.25E-25 119 C170B_HUMAN reviewed Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) CEP170B FAM68C KIAA0284 Homo sapiens (Human) 1589 0 GO:0005737; GO:0005874 0 0 0 PF15308;PF00498; A0JM12 CHOYP_BM1_57400.5.7 m.58033 sp MEG10_XENTR 36.474 329 177 17 184 506 310 612 1.26E-37 152 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A0JPI9 CHOYP_LOC100372392.7.8 m.59534 sp LR74A_RAT 33.535 331 218 2 80 409 50 379 1.26E-49 178 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A2AJ76 CHOYP_ISCW_ISCW014027.1.2 m.12014 sp HMCN2_MOUSE 24.138 406 248 20 253 623 806 1186 1.26E-08 63.2 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A8MU46 CHOYP_RS23.3.9 m.22893 sp SMTL1_HUMAN 67.327 101 33 0 1 101 346 446 1.26E-46 158 SMTL1_HUMAN reviewed Smoothelin-like protein 1 SMTNL1 Homo sapiens (Human) 457 negative regulation of vasodilation [GO:0045908]; positive regulation of vasoconstriction [GO:0045907] GO:0005634; GO:0005737; GO:0031430; GO:0031674; GO:0043292; GO:0045907; GO:0045908 0 0 0 PF00307; B0C431 CHOYP_LOC580666.2.2 m.24829 sp RS11_ACAM1 40.367 109 65 0 76 184 21 129 1.26E-24 96.3 RS11_ACAM1 reviewed 30S ribosomal protein S11 rpsK rps11 AM1_1254 Acaryochloris marina (strain MBIC 11017) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00411; B2RXR6 CHOYP_contig_056307 m.66864 sp ANR44_MOUSE 41.722 151 87 1 20 169 165 315 1.26E-25 106 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; B3EWY9 CHOYP_LOC590125.1.7 m.14320 sp MLP_ACRMI 27.82 1064 623 35 824 1828 388 1365 1.26E-98 357 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B3EWZ5 CHOYP_LOC580670.4.6 m.19322 sp MLRP1_ACRMI 42.5 160 80 7 2 150 925 1083 1.26E-20 92 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D3YXG0 CHOYP_BRAFLDRAFT_236936.6.6 m.55690 sp HMCN1_MOUSE 41.887 265 119 13 86 350 4582 4811 1.26E-53 201 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D4B1Z7 CHOYP_ARB_02478.1.1 m.29725 sp A2478_ARTBC 26.998 563 313 19 36 530 28 560 1.26E-39 155 A2478_ARTBC reviewed Uncharacterized FAD-linked oxidoreductase ARB_02478 (EC 1.-.-.-) ARB_02478 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) 565 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF08031;PF01565; H2KZM6 CHOYP_PTPRC.6.14 m.39086 sp PTPR_CAEEL 29.358 109 75 1 51 157 1296 1404 1.26E-10 62.8 PTPR_CAEEL reviewed Receptor-type tyrosine-protein phosphatase (EC 3.1.3.48) clr-1 F56D1.4 Caenorhabditis elegans 1409 negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0005001; GO:0005886; GO:0016021; GO:0035335; GO:0040037 0 0 0 PF00102; O00370 CHOYP_LOC100537145.2.3 m.37084 sp LORF2_HUMAN 29.026 503 348 6 7 504 390 888 1.26E-58 214 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O05972 CHOYP_LOC574855.8.9 m.52798 sp Y028_RICPR 34.653 101 63 3 162 260 47 146 1.26E-08 58.5 Y028_RICPR reviewed Uncharacterized protein RP028 RP028 Rickettsia prowazekii (strain Madrid E) 250 0 0 0 0 0 PF13847; O16277 CHOYP_LOC100635715.5.9 m.12660 sp H16_CAEEL 51.22 123 52 3 35 149 1 123 1.26E-25 101 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O43934 CHOYP_LOC100369212.1.1 m.15383 sp MFS11_HUMAN 51.2 375 163 5 1 359 79 449 1.26E-127 376 MFS11_HUMAN reviewed UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11) (Protein ET) MFSD11 ET Homo sapiens (Human) 449 0 GO:0016021 0 0 cd06174; PF05978; O62640 CHOYP_TIAP2.11.13 m.60213 sp PIAP_PIG 29.373 303 169 9 204 493 88 358 1.26E-34 136 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; O70277 CHOYP_LOC100213744.2.19 m.1815 sp TRIM3_RAT 23.103 290 173 13 287 548 465 732 1.26E-06 55.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P09478 CHOYP_LOC100903964.1.1 m.9339 sp ACH1_DROME 36.508 315 188 3 29 334 21 332 1.26E-69 233 ACH1_DROME reviewed Acetylcholine receptor subunit alpha-like 1 (Nicotinic acetylcholine receptor alpha 1) nAChRalpha1 Acr96Aa AcrB als nAcRalpha-96Aa CG5610 Drosophila melanogaster (Fruit fly) 567 "cation transport [GO:0006812]; neuromuscular synaptic transmission [GO:0007274]; response to insecticide [GO:0017085]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0006812; GO:0007165; GO:0007271; GO:0007274; GO:0017085; GO:0030054; GO:0035094; GO:0045211 0 0 0 PF02931;PF02932; P0AGF9 CHOYP_TSIB_0893.1.1 m.10314 sp TDCB_SHIFL 36.503 326 184 6 421 736 11 323 1.26E-41 158 TDCB_SHIFL reviewed L-threonine dehydratase catabolic TdcB (EC 4.3.1.19) (L-serine dehydratase) (EC 4.3.1.17) (Threonine deaminase) tdcB SF3157 S3369 Shigella flexneri 329 L-threonine catabolic process to propionate [GO:0070689] GO:0000166; GO:0003941; GO:0004794; GO:0030170; GO:0070689 PATHWAY: Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4. 0 0 PF00291; P13668 CHOYP_CPIPJ_CPIJ005489.1.1 m.43655 sp STMN1_RAT 41.985 131 74 2 43 171 9 139 1.26E-15 75.5 STMN1_RAT reviewed Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Pr22 protein) (Prosolin) (pp17) Stmn1 Lap18 Rattus norvegicus (Rat) 149 axonogenesis [GO:0007409]; brain development [GO:0007420]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of cellular component movement [GO:0051272]; regulation of cytoskeleton organization [GO:0051493]; response to virus [GO:0009615] GO:0005737; GO:0005829; GO:0005874; GO:0007019; GO:0007052; GO:0007409; GO:0007420; GO:0009615; GO:0015631; GO:0016020; GO:0031115; GO:0031175; GO:0035556; GO:0043005; GO:0051272; GO:0051493; GO:0070062 0 0 0 PF00836; P15475 CHOYP_ACT5.1.3 m.30368 sp ACTB_XENBO 91.129 248 22 0 1 248 1 248 1.26E-167 472 ACTB_XENBO reviewed "Actin, cytoplasmic 1 (Beta actin)" actb Xenopus borealis (Kenyan clawed frog) 376 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; P16067 CHOYP_LOC580109.1.3 m.6450 sp ANPRB_RAT 57.447 235 90 3 386 618 816 1042 1.26E-76 268 ANPRB_RAT reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) Npr2 Rattus norvegicus (Rat) 1047 bone development [GO:0060348]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168]; single organism reproductive process [GO:0044702] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007168; GO:0008074; GO:0016941; GO:0017046; GO:0035556; GO:0044702; GO:0051447; GO:0060348; GO:0097011; GO:1900194 0 0 0 PF01094;PF00211;PF07714; P22031 CHOYP_BRAFLDRAFT_95854.2.6 m.22626 sp LEG_HELCR 41.111 90 50 1 30 116 13 102 1.26E-12 65.9 LEG_HELCR reviewed D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 105 0 GO:0005737; GO:0030246 0 0 0 PF02140; P35220 CHOYP_LOC100368833.1.1 m.52947 sp CTNA_DROME 25.784 574 401 13 12 574 27 586 1.26E-40 167 CTNA_DROME reviewed Catenin alpha alpha-Cat CG17947 Drosophila melanogaster (Fruit fly) 917 adherens junction organization [GO:0034332]; cell adhesion [GO:0007155]; cytoskeletal anchoring at plasma membrane [GO:0007016]; epithelium development [GO:0060429]; establishment or maintenance of cell polarity [GO:0007163]; germarium-derived egg chamber formation [GO:0007293]; head morphogenesis [GO:0060323]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720] GO:0003779; GO:0005198; GO:0005737; GO:0005886; GO:0005912; GO:0005913; GO:0005914; GO:0005915; GO:0007016; GO:0007155; GO:0007163; GO:0007293; GO:0008092; GO:0015629; GO:0016342; GO:0030720; GO:0034332; GO:0060323; GO:0060429 0 0 0 PF01044; P47990 CHOYP_LOC100374085.1.1 m.66677 sp XDH_CHICK 42.718 103 58 1 1 103 1234 1335 1.26E-23 97.1 XDH_CHICK reviewed Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] XDH Gallus gallus (Chicken) 1358 urate biosynthetic process [GO:0034418]; xanthine catabolic process [GO:0009115] GO:0004854; GO:0004855; GO:0005506; GO:0005777; GO:0005829; GO:0009055; GO:0009115; GO:0016614; GO:0016903; GO:0030151; GO:0034418; GO:0043546; GO:0050660; GO:0051537; GO:0070674 0 0 0 PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; P60517 CHOYP_NEMVEDRAFT_V1G165338.1.1 m.60296 sp GBRAP_RAT 93.966 116 7 0 45 160 1 116 1.26E-76 226 GBRAP_RAT reviewed Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) Gabarap Rattus norvegicus (Rat) 117 autophagosome assembly [GO:0000045]; cellular response to nitrogen starvation [GO:0006995]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; microtubule cytoskeleton organization [GO:0000226]; mitophagy [GO:0000422]; protein transport [GO:0015031] GO:0000045; GO:0000139; GO:0000226; GO:0000421; GO:0000422; GO:0005764; GO:0005776; GO:0005790; GO:0005829; GO:0005874; GO:0005875; GO:0005886; GO:0005930; GO:0006995; GO:0008625; GO:0015031; GO:0015629; GO:0031410; GO:0044297; GO:0048471; GO:0050811; GO:0097225 0 0 cd01611; PF02991; P70122 CHOYP_SBDS.1.1 m.27786 sp SBDS_MOUSE 71.486 249 69 1 1 249 1 247 1.26E-123 354 SBDS_MOUSE reviewed Ribosome maturation protein SBDS (Protein 22A3) (Shwachman-Bodian-Diamond syndrome protein homolog) Sbds Mus musculus (Mouse) 250 bone marrow development [GO:0048539]; bone mineralization [GO:0030282]; cell proliferation [GO:0008283]; inner cell mass cell proliferation [GO:0001833]; leukocyte chemotaxis [GO:0030595]; mature ribosome assembly [GO:0042256]; mitotic spindle organization [GO:0007052]; rRNA processing [GO:0006364] GO:0000922; GO:0001833; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0007052; GO:0008017; GO:0008283; GO:0019843; GO:0030282; GO:0030595; GO:0042256; GO:0043022; GO:0044822; GO:0048539 0 0 0 PF01172;PF09377; P70279 CHOYP_BRAFLDRAFT_128100.1.1 m.10153 sp SURF6_MOUSE 32.075 159 95 1 221 366 188 346 1.26E-23 103 SURF6_MOUSE reviewed Surfeit locus protein 6 Surf6 Surf-6 Mus musculus (Mouse) 355 ribosome assembly [GO:0042255]; ribosome biogenesis [GO:0042254] GO:0001652; GO:0003677; GO:0003723; GO:0005654; GO:0005730; GO:0042254; GO:0042255; GO:0044822 0 0 0 PF04935; P79385 CHOYP_SMP_135520.1.2 m.38817 sp MFGM_PIG 32.5 320 200 8 25 328 90 409 1.26E-48 176 MFGM_PIG reviewed Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) (Sperm surface protein SP47) (PP47) MFGE8 Sus scrofa (Pig) 409 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; single fertilization [GO:0007338] GO:0001525; GO:0002080; GO:0005576; GO:0007155; GO:0007338 0 0 0 PF00008;PF00754; P80090 CHOYP_MPI1.1.1 m.35779 sp MPI3_LYMST 27.966 118 81 1 37 154 9 122 1.26E-09 56.2 MPI3_LYMST reviewed Molluscan insulin-related peptide 3 (MIP III) [Cleaved into: Molluscan insulin-related peptide 3 B chain; Molluscan insulin-related peptide 3 A chain] 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 122 0 GO:0005576; GO:0030133 0 0 0 PF00049; Q04832 CHOYP_HEXP.1.1 m.12802 sp HEXP_LEIMA 35.185 108 51 4 17 111 55 156 1.26E-12 67.4 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q05AQ3 CHOYP_LOC576399.1.1 m.8452 sp S2542_XENTR 60.345 290 110 3 50 336 32 319 1.26E-116 343 S2542_XENTR reviewed Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42) slc25a42 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 327 ADP transport [GO:0015866]; AMP transport [GO:0080121]; ATP transport [GO:0015867]; coenzyme A transmembrane transport [GO:0035349]; translation [GO:0006412] GO:0003735; GO:0005347; GO:0005739; GO:0005743; GO:0006412; GO:0015217; GO:0015228; GO:0015866; GO:0015867; GO:0016021; GO:0035349; GO:0043262; GO:0080121; GO:0080122 0 0 0 PF00153; Q08DV6 CHOYP_ASB3.1.1 m.51102 sp ASB3_BOVIN 39.521 334 189 6 1 330 1 325 1.26E-66 229 ASB3_BOVIN reviewed Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Bos taurus (Bovine) 525 intracellular signal transduction [GO:0035556] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0031625; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q13442 CHOYP_BRAFLDRAFT_118658.2.2 m.56465 sp HAP28_HUMAN 66.667 78 25 1 106 183 73 149 1.26E-25 100 HAP28_HUMAN reviewed 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) PDAP1 HASPP28 Homo sapiens (Human) 181 cell proliferation [GO:0008283]; signal transduction [GO:0007165] GO:0007165; GO:0008283; GO:0044822 0 0 0 PF10252; Q16595 CHOYP_LOC100571875.1.1 m.48861 sp FRDA_HUMAN 46.094 128 69 0 46 173 81 208 1.26E-33 121 FRDA_HUMAN reviewed "Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN)]" FXN FRDA X25 Homo sapiens (Human) 210 adult walking behavior [GO:0007628]; aerobic respiration [GO:0009060]; cellular iron ion homeostasis [GO:0006879]; cellular response to hydrogen peroxide [GO:0070301]; embryo development ending in birth or egg hatching [GO:0009792]; heme biosynthetic process [GO:0006783]; ion transport [GO:0006811]; iron incorporation into metallo-sulfur cluster [GO:0018283]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of organ growth [GO:0046621]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; oxidative phosphorylation [GO:0006119]; positive regulation of aconitate hydratase activity [GO:1904234]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell growth [GO:0030307]; positive regulation of cell proliferation [GO:0008284]; positive regulation of lyase activity [GO:0051349]; positive regulation of succinate dehydrogenase activity [GO:1904231]; proprioception [GO:0019230]; protein autoprocessing [GO:0016540]; regulation of ferrochelatase activity [GO:0010722]; response to iron ion [GO:0010039]; small molecule metabolic process [GO:0044281] GO:0004322; GO:0005739; GO:0005759; GO:0005829; GO:0006119; GO:0006783; GO:0006811; GO:0006879; GO:0007005; GO:0007628; GO:0008198; GO:0008199; GO:0008284; GO:0009060; GO:0009792; GO:0010039; GO:0010722; GO:0016540; GO:0018283; GO:0019230; GO:0030307; GO:0034986; GO:0040015; GO:0043066; GO:0043085; GO:0044281; GO:0046621; GO:0051349; GO:0051536; GO:0051537; GO:0070301; GO:0090201; GO:1904231; GO:1904234 0 0 0 PF01491; Q1L8X9 CHOYP_VGLU3.1.1 m.38403 sp VGLU3_DANRE 35.408 466 282 7 9 466 59 513 1.26E-95 304 VGLU3_DANRE reviewed Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) slc17a8 vglut3 si:ch211-264e16.4 Danio rerio (Zebrafish) (Brachydanio rerio) 590 equilibrioception [GO:0050957]; neurotransmitter transport [GO:0006836]; regulation of synapse structure or activity [GO:0050803]; sodium ion transport [GO:0006814]; vestibular reflex [GO:0060005] GO:0005313; GO:0006814; GO:0006836; GO:0015293; GO:0016021; GO:0030054; GO:0030672; GO:0043005; GO:0050803; GO:0050957; GO:0060005 0 0 cd06174; PF07690; Q1LV15 CHOYP_contig_007415 m.8569 sp DAW1_DANRE 27.016 248 163 8 371 608 147 386 1.26E-12 73.9 DAW1_DANRE reviewed Dynein assembly factor with WDR repeat domains 1 (Outer row dynein assembly protein 16 homolog) (WD repeat-containing protein 69) daw1 oda16 wdr69 si:dkey-223n17.5 zgc:153626 Danio rerio (Zebrafish) (Brachydanio rerio) 415 axonemal dynein complex assembly [GO:0070286]; cilium-dependent cell motility [GO:0060285]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368] GO:0005929; GO:0007368; GO:0060271; GO:0060285; GO:0070286 0 0 0 PF00400; Q24K15 CHOYP_FCNV4.1.1 m.62608 sp ANGP4_BOVIN 42.857 98 55 1 1 98 317 413 1.26E-25 102 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q47944 CHOYP_LOC100903758.1.1 m.43697 sp SDH_GLUOY 35.889 574 311 17 30 589 1 531 1.26E-98 313 SDH_GLUOY reviewed L-sorbose 1-dehydrogenase (SDH) (EC 1.1.99.32) 0 Gluconobacter oxydans (Gluconobacter suboxydans) 531 0 GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; Q498J9 CHOYP_BRAFLDRAFT_241400.1.1 m.44544 sp MBLC1_XENLA 49.49 196 94 2 2 195 27 219 1.26E-59 190 MBLC1_XENLA reviewed Metallo-beta-lactamase domain-containing protein 1 (EC 3.-.-.-) mblac1 Xenopus laevis (African clawed frog) 233 0 GO:0016787; GO:0046872 0 0 0 PF00753; Q4PJX1 CHOYP_ISCW_ISCW017474.1.1 m.18280 sp ODR4_MOUSE 34.419 430 256 12 23 446 1 410 1.26E-75 247 ODR4_MOUSE reviewed Protein odr-4 homolog (mODR-4) Odr4 Mus musculus (Mouse) 447 0 GO:0016021 0 0 0 PF14778; Q4ZJM9 CHOYP_C1QL4.8.10 m.63566 sp C1QL4_MOUSE 35.714 126 70 5 53 172 110 230 1.26E-09 58.9 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5RHP9 CHOYP_LOC100179357.5.6 m.45322 sp ERIC3_HUMAN 33.694 555 262 19 1 488 1 516 1.26E-69 262 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q5SSL4 CHOYP_LOC100176232.1.1 m.24645 sp ABR_MOUSE 37.23 787 413 16 565 1306 89 839 1.26E-151 483 ABR_MOUSE reviewed Active breakpoint cluster region-related protein Abr Mus musculus (Mouse) 859 actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; inner ear morphogenesis [GO:0042472]; intracellular signal transduction [GO:0035556]; negative regulation of blood vessel remodeling [GO:0060313]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular extravasation [GO:0002692]; negative regulation of inflammatory response [GO:0050728]; negative regulation of neutrophil degranulation [GO:0043314]; neuromuscular process controlling balance [GO:0050885]; positive regulation of phagocytosis [GO:0050766]; regulation of Rho protein signal transduction [GO:0035023]; regulation of vascular permeability [GO:0043114]; response to lipopolysaccharide [GO:0032496] GO:0002692; GO:0005089; GO:0005096; GO:0005829; GO:0005886; GO:0007420; GO:0016020; GO:0030036; GO:0030336; GO:0032496; GO:0035023; GO:0035556; GO:0042472; GO:0043114; GO:0043314; GO:0050728; GO:0050766; GO:0050885; GO:0060313 0 0 0 PF00168;PF00169;PF00620;PF00621; Q60648 CHOYP_LOC101069006.1.2 m.5484 sp SAP3_MOUSE 31.69 142 89 5 368 507 28 163 1.26E-17 84.3 SAP3_MOUSE reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) 193 ganglioside catabolic process [GO:0006689]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; neurological system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; positive regulation of hydrolase activity [GO:0051345] GO:0004563; GO:0005319; GO:0005739; GO:0005764; GO:0005889; GO:0006689; GO:0007611; GO:0008047; GO:0009313; GO:0009898; GO:0016004; GO:0019915; GO:0032428; GO:0045179; GO:0050877; GO:0050885; GO:0051345; GO:0070062 0 0 0 PF02221; Q62656 CHOYP_PTPRC.3.14 m.20946 sp PTPRZ_RAT 28.194 454 304 8 5 440 1837 2286 1.26E-46 176 PTPRZ_RAT reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (3F8 chondroitin sulfate proteoglycan) (3H1 keratan sulfate proteoglycan) (Phosphacan) Ptprz1 Ptprz Ptpz Rattus norvegicus (Rat) 2316 axonal fasciculation [GO:0007413]; brain development [GO:0007420]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; neuron development [GO:0048666]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; protein dephosphorylation [GO:0006470]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0004725; GO:0005615; GO:0005737; GO:0006470; GO:0007413; GO:0007420; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0010976; GO:0016020; GO:0016021; GO:0016791; GO:0017134; GO:0021766; GO:0030027; GO:0030175; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048666; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; Q6DCY9 CHOYP_LOC583843.1.1 m.11191 sp HAUS3_XENLA 29.47 604 409 6 2 604 3 590 1.26E-74 253 HAUS3_XENLA reviewed HAUS augmin-like complex subunit 3 haus3 Xenopus laevis (African clawed frog) 597 cell division [GO:0051301]; centrosome organization [GO:0051297]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0005737; GO:0005815; GO:0005819; GO:0005874; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 PF14932; Q6DFV8 CHOYP_BRAFLDRAFT_80496.8.10 m.49028 sp VWDE_MOUSE 22.426 544 306 21 204 666 411 919 1.26E-18 95.1 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6H236 CHOYP_contig_041263 m.47052 sp PEG3_BOVIN 43.457 405 158 26 5 344 1027 1425 1.26E-19 94 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6IQ97 CHOYP_LOC100372582.1.2 m.8558 sp RBM41_DANRE 54.167 72 33 0 3 74 2 73 1.26E-22 99.4 RBM41_DANRE reviewed RNA-binding protein 4.1 (RNA-binding motif protein 4.1) rbm4.1 rbm4 Danio rerio (Zebrafish) (Brachydanio rerio) 419 0 GO:0000166; GO:0003723; GO:0005634; GO:0008270 0 0 0 PF00076;PF00098; Q6NTV6 CHOYP_LOC100213938.1.1 m.54030 sp INF2_XENLA 36.054 441 265 6 50 480 627 1060 1.26E-82 284 INF2_XENLA reviewed Inverted formin-2 inf2 Xenopus laevis (African clawed frog) 1099 actin cytoskeleton organization [GO:0030036] GO:0030036 0 0 0 PF06367;PF06371;PF02181; Q6PFY8 CHOYP_TRIM45.4.9 m.18208 sp TRI45_MOUSE 24.519 208 146 5 11 211 132 335 1.26E-08 60.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6Q899 CHOYP_BRAFLDRAFT_249506.2.2 m.60314 sp DDX58_MOUSE 36.155 697 400 17 685 1359 241 914 1.26E-108 369 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6R7E9 CHOYP_Y077.1.1 m.27646 sp Y080_OSHVF 100 116 0 0 1 116 1 116 1.26E-82 239 Y080_OSHVF reviewed Uncharacterized protein ORF80 ORF80 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 116 0 GO:0016021; GO:0033644 0 0 0 0 Q6Z7K5 CHOYP_NEMVEDRAFT_V1G81238.1.1 m.20045 sp MTP3_ORYSJ 30.233 86 50 2 22 107 228 303 1.26E-07 51.6 MTP3_ORYSJ reviewed Metal tolerance protein 3 (OsMTP3) MTP3 Os02g0775100 LOC_Os02g53490 OJ1448_G06.19 OsJ_08570 Oryza sativa subsp. japonica (Rice) 410 regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043] GO:0005385; GO:0005774; GO:0010043; GO:0016020; GO:0016021; GO:0061088 0 0 0 PF01545;PF16916; Q7LHG5 CHOYP_LOC100372741.2.3 m.34230 sp YI31B_YEAST 40 265 158 1 210 473 610 874 1.26E-58 213 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q868Z9 CHOYP_DPSE_GA17283.2.3 m.11731 sp PPN_DROME 33.968 683 302 17 285 847 1490 2143 1.26E-99 359 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q86T96 CHOYP_RNF180.1.1 m.1238 sp RN180_HUMAN 43.478 92 51 1 243 334 428 518 1.26E-15 82.4 RN180_HUMAN reviewed E3 ubiquitin-protein ligase RNF180 (EC 6.3.2.-) (RING finger protein 180) RNF180 Homo sapiens (Human) 592 adult behavior [GO:0030534]; norepinephrine metabolic process [GO:0042415]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein polyubiquitination [GO:0000209]; regulation of catalytic activity [GO:0050790]; serotonin metabolic process [GO:0042428] GO:0000209; GO:0005635; GO:0008270; GO:0016021; GO:0016874; GO:0030534; GO:0031227; GO:0031398; GO:0031624; GO:0032436; GO:0042415; GO:0042428; GO:0050790; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8BLJ3 CHOYP_NEMVEDRAFT_V1G183467.1.1 m.24852 sp PLCX3_MOUSE 31.111 315 208 5 1 310 1 311 1.26E-50 174 PLCX3_MOUSE reviewed PI-PLC X domain-containing protein 3 Plcxd3 Mus musculus (Mouse) 321 lipid catabolic process [GO:0016042] GO:0004871; GO:0008081; GO:0016042 0 0 0 0 Q8IVG5 CHOYP_LOC100368821.4.7 m.41790 sp SAM9L_HUMAN 24.635 1165 714 49 17 1094 495 1582 1.26E-60 232 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8IY92 CHOYP_SLX4.1.1 m.278 sp SLX4_HUMAN 25.637 628 351 22 105 648 268 863 1.26E-33 145 SLX4_HUMAN reviewed Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) SLX4 BTBD12 KIAA1784 KIAA1987 Homo sapiens (Human) 1834 DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289]; positive regulation of t-circle formation [GO:1904431]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; t-circle formation [GO:0090656] GO:0000724; GO:0004520; GO:0005654; GO:0005737; GO:0006260; GO:0006281; GO:0006289; GO:0008047; GO:0010792; GO:0017108; GO:0030054; GO:0033557; GO:0036297; GO:0072429; GO:0090656; GO:1904431 0 0 0 PF00651;PF09494; Q8K0U4 CHOYP_BRAFLDRAFT_208436.26.32 m.60854 sp HS12A_MOUSE 30.675 652 363 16 19 615 56 673 1.26E-89 294 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N2E2 CHOYP_BRAFLDRAFT_80496.7.10 m.35633 sp VWDE_HUMAN 22.924 301 218 6 114 404 747 1043 1.26E-10 68.2 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N8A2 CHOYP_ANR44.1.5 m.29530 sp ANR44_HUMAN 32.108 408 265 5 18 423 12 409 1.26E-50 187 ANR44_HUMAN reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) 993 0 0 0 0 0 PF00023;PF12796; Q8NBP5 CHOYP_LOC100150581.1.1 m.46174 sp MFSD9_HUMAN 37.198 414 243 3 9 405 43 456 1.26E-85 272 MFSD9_HUMAN reviewed Major facilitator superfamily domain-containing protein 9 MFSD9 PSEC0066 Homo sapiens (Human) 474 transmembrane transport [GO:0055085] GO:0005215; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q8R151 CHOYP_LOC100891217.1.1 m.63544 sp ZNFX1_MOUSE 36.697 327 177 12 109 418 1337 1650 1.26E-43 168 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R418 CHOYP_DICER.2.3 m.18726 sp DICER_MOUSE 39.845 517 277 12 1 507 820 1312 1.26E-95 321 DICER_MOUSE reviewed Endoribonuclease Dicer (EC 3.1.26.3) (Double-strand-specific ribonuclease mDCR-1) Dicer1 Dicer Mdcr Mus musculus (Mouse) 1916 "anatomical structure development [GO:0048856]; angiogenesis [GO:0001525]; apoptotic DNA fragmentation [GO:0006309]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac muscle cell development [GO:0055013]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cartilage development [GO:0051216]; cell proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; chromatin silencing at centromere outer repeat region [GO:1990141]; conversion of ds siRNA to ss siRNA [GO:0036404]; conversion of ds siRNA to ss siRNA involved in RNA interference [GO:0033168]; defense response to virus [GO:0051607]; digestive tract development [GO:0048565]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; epidermis morphogenesis [GO:0048730]; ganglion development [GO:0061548]; hair follicle cell proliferation [GO:0071335]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; inner ear receptor cell development [GO:0060119]; intestinal epithelial cell development [GO:0060576]; lung development [GO:0030324]; meiotic spindle organization [GO:0000212]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA stabilization [GO:0048255]; multicellular organism growth [GO:0035264]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nerve development [GO:0021675]; neuron projection morphogenesis [GO:0048812]; olfactory bulb interneuron differentiation [GO:0021889]; peripheral nervous system myelin formation [GO:0032290]; positive regulation of gene expression [GO:0010628]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of myelination [GO:0031643]; positive regulation of Schwann cell differentiation [GO:0014040]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; production of siRNA involved in RNA interference [GO:0030422]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of enamel mineralization [GO:0070173]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of miRNA metabolic process [GO:2000628]; regulation of muscle cell apoptotic process [GO:0010660]; regulation of myelination [GO:0031641]; regulation of neurogenesis [GO:0050767]; regulation of neuron differentiation [GO:0045664]; regulation of Notch signaling pathway [GO:0008593]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; regulation of oligodendrocyte differentiation [GO:0048713]; regulation of protein phosphorylation [GO:0001932]; regulation of regulatory T cell differentiation [GO:0045589]; regulation of RNA metabolic process [GO:0051252]; regulation of stem cell differentiation [GO:2000736]; regulation of viral genome replication [GO:0045069]; reproductive structure development [GO:0048608]; RNA interference [GO:0016246]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]; siRNA loading onto RISC involved in RNA interference [GO:0035087]; spinal cord motor neuron differentiation [GO:0021522]; spindle assembly [GO:0051225]; spleen development [GO:0048536]; stem cell population maintenance [GO:0019827]; targeting of mRNA for destruction involved in RNA interference [GO:0030423]; zygote asymmetric cell division [GO:0010070]" GO:0000122; GO:0000212; GO:0001525; GO:0001932; GO:0001942; GO:0003677; GO:0003725; GO:0004386; GO:0004521; GO:0004525; GO:0004530; GO:0005524; GO:0005634; GO:0005737; GO:0006309; GO:0006396; GO:0008283; GO:0008593; GO:0009791; GO:0010070; GO:0010468; GO:0010626; GO:0010628; GO:0010660; GO:0014040; GO:0014835; GO:0016075; GO:0016246; GO:0016442; GO:0019827; GO:0019904; GO:0021522; GO:0021675; GO:0021889; GO:0021987; GO:0030324; GO:0030326; GO:0030422; GO:0030423; GO:0031054; GO:0031069; GO:0031641; GO:0031643; GO:0032290; GO:0033168; GO:0034507; GO:0035068; GO:0035087; GO:0035116; GO:0035196; GO:0035197; GO:0035198; GO:0035264; GO:0035280; GO:0036404; GO:0042487; GO:0045069; GO:0045589; GO:0045595; GO:0045664; GO:0045944; GO:0046872; GO:0048255; GO:0048536; GO:0048565; GO:0048608; GO:0048713; GO:0048730; GO:0048754; GO:0048812; GO:0048856; GO:0050727; GO:0050767; GO:0051216; GO:0051225; GO:0051252; GO:0051607; GO:0051726; GO:0055013; GO:0060119; GO:0060253; GO:0060576; GO:0061309; GO:0061548; GO:0070173; GO:0070578; GO:0070883; GO:0071335; GO:0090502; GO:1990141; GO:2000628; GO:2000630; GO:2000736 0 0 cd00593; PF03368;PF00271;PF02170;PF04851;PF00636; Q92010 CHOYP_ZN841.1.1 m.40155 sp ZBT14_CHICK 41.463 123 69 1 23 145 322 441 1.26E-22 103 ZBT14_CHICK reviewed Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 5) (ZF5) ZBTB14 ZFP161 Gallus gallus (Chicken) 448 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0044212; GO:0045892; GO:0046872 0 0 0 PF00651;PF00096; Q96CD2 CHOYP_PPCDC.1.1 m.41651 sp COAC_HUMAN 60.452 177 69 1 16 192 20 195 1.26E-79 239 COAC_HUMAN reviewed Phosphopantothenoylcysteine decarboxylase (PPC-DC) (EC 4.1.1.36) (CoaC) PPCDC COAC MDS018 UNQ9365/PRO34154 Homo sapiens (Human) 204 coenzyme A biosynthetic process [GO:0015937]; coenzyme biosynthetic process [GO:0009108] GO:0004633; GO:0005829; GO:0009108; GO:0015937; GO:0042802 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5. 0 0 PF02441; Q96RW7 CHOYP_BRAFLDRAFT_205939.1.3 m.51363 sp HMCN1_HUMAN 37.097 248 107 15 17 228 5109 5343 1.26E-32 128 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99M80 CHOYP_PTPRA.2.22 m.3118 sp PTPRT_MOUSE 33.679 579 362 13 627 1190 882 1453 1.26E-82 300 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99M80 CHOYP_PTPRT.25.45 m.49735 sp PTPRT_MOUSE 32.155 594 377 15 193 767 867 1453 1.26E-78 280 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9P2N4 CHOYP_BRAFLDRAFT_67741.2.2 m.37743 sp ATS9_HUMAN 25.121 207 122 9 248 435 1735 1927 1.26E-07 58.2 ATS9_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) 1935 glycoprotein catabolic process [GO:0006516]; multicellular organism development [GO:0007275]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; vesicle-mediated transport [GO:0016192] GO:0004222; GO:0005578; GO:0005615; GO:0005783; GO:0006508; GO:0006516; GO:0007275; GO:0008237; GO:0008270; GO:0009986; GO:0015031; GO:0016192; GO:0045636 0 0 0 PF05986;PF08685;PF01562;PF01421;PF00090; Q9R1R2 CHOYP_BRAFLDRAFT_87295.6.9 m.52671 sp TRIM3_MOUSE 26.05 119 85 2 18 134 626 743 1.26E-08 56.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9S725 CHOYP_LOC100635352.1.1 m.9480 sp 4CL2_ARATH 37.67 515 305 7 69 570 40 551 1.26E-103 326 4CL2_ARATH reviewed 4-coumarate--CoA ligase 2 (4CL 2) (EC 6.2.1.12) (4-coumarate--CoA ligase isoform 2) (At4CL2) (4-coumaroyl-CoA synthase 2) 4CL2 At3g21240 MXL8.10 Arabidopsis thaliana (Mouse-ear cress) 556 phenylpropanoid metabolic process [GO:0009698] GO:0005524; GO:0009698; GO:0016207 "PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2." 0 0 PF00501;PF13193; Q9UL51 CHOYP_LOC100533424.1.1 m.31683 sp HCN2_HUMAN 61.187 219 76 3 1 211 478 695 1.26E-85 283 HCN2_HUMAN reviewed Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) HCN2 BCNG2 Homo sapiens (Human) 889 cell-cell signaling [GO:0007267]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; potassium ion transmembrane transport [GO:0071805]; regulation of membrane potential [GO:0042391]; sodium ion transmembrane transport [GO:0035725] GO:0005222; GO:0005248; GO:0005249; GO:0005886; GO:0005887; GO:0007267; GO:0008076; GO:0030552; GO:0035725; GO:0042391; GO:0042802; GO:0071320; GO:0071321; GO:0071805 0 0 0 PF00027;PF00520;PF08412; Q9W4Y2 CHOYP_LOC100864469.1.1 m.43479 sp PDFR_DROME 26.347 334 206 14 10 326 127 437 1.26E-20 98.2 PDFR_DROME reviewed PDF receptor (Pigment-dispersing factor receptor) (Protein groom-of-PDF) Pdfr gop Han CG13758 Drosophila melanogaster (Fruit fly) 669 cell surface receptor signaling pathway [GO:0007166]; circadian behavior [GO:0048512]; circadian rhythm [GO:0007623]; circadian sleep/wake cycle [GO:0042745]; circadian temperature homeostasis [GO:0060086]; copper ion homeostasis [GO:0055070]; G-protein coupled receptor signaling pathway [GO:0007186]; gravitaxis [GO:0042332]; locomotor rhythm [GO:0045475]; neuropeptide signaling pathway [GO:0007218]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; regulation of circadian sleep/wake cycle [GO:0042749] GO:0004948; GO:0005887; GO:0007166; GO:0007186; GO:0007218; GO:0007623; GO:0008188; GO:0010579; GO:0016021; GO:0042332; GO:0042745; GO:0042749; GO:0043005; GO:0043025; GO:0045475; GO:0048512; GO:0055070; GO:0060086 0 0 0 PF00002;PF02793; Q9W6Y0 CHOYP_MPET_1013.2.2 m.58809 sp RS30_ORYLA 67.241 58 19 0 96 153 1 58 1.26E-18 78.2 RS30_ORYLA reviewed 40S ribosomal protein S30 fau rps30 Oryzias latipes (Japanese rice fish) (Japanese killifish) 59 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF04758; Q9W740 CHOYP_LOC693258.1.1 m.54528 sp NOGG2_DANRE 29.255 188 109 3 59 246 49 212 1.26E-22 95.1 NOGG2_DANRE reviewed Noggin-2 nog2 Danio rerio (Zebrafish) (Brachydanio rerio) 212 cartilage development [GO:0051216]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell differentiation [GO:0045596]; nervous system development [GO:0007399]; osteoblast differentiation [GO:0001649]; skeletal system development [GO:0001501] GO:0001501; GO:0001649; GO:0005615; GO:0007399; GO:0030514; GO:0045596; GO:0051216 0 0 0 0 Q9XWB9 CHOYP_NEMVEDRAFT_V1G198958.4.6 m.34386 sp BAT36_CAEEL 33.333 96 62 1 30 125 161 254 1.26E-07 55.8 BAT36_CAEEL reviewed BTB and MATH domain-containing protein 36 bath-36 Y75B12B.4 Caenorhabditis elegans 320 0 0 0 0 0 PF00651;PF00917; Q9XWD6 CHOYP_SREC2.6.9 m.42862 sp CED1_CAEEL 37.838 222 128 6 147 367 637 849 1.26E-28 121 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; Q9YGJ7 CHOYP_LOC101282600.1.1 m.28357 sp PA2A8_DABPA 38.462 143 75 4 6 147 3 133 1.26E-25 98.6 PA2A8_DABPA reviewed Acidic phospholipase A2 VP8 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) 0 Daboia palaestinae (Palestine viper) (Vipera palaestinae) 137 lipid catabolic process [GO:0016042] GO:0004623; GO:0005509; GO:0005576; GO:0016042 0 0 0 PF00068; A4W960 CHOYP_BRAFLDRAFT_75823.2.2 m.4205 sp YMDB_ENT38 36.25 160 93 4 375 529 4 159 1.27E-18 87 YMDB_ENT38 reviewed O-acetyl-ADP-ribose deacetylase (EC 3.5.1.-) (Regulator of RNase III activity) ymdB Ent638_1561 Enterobacter sp. (strain 638) 180 negative regulation of ribonuclease activity [GO:0060701]; purine nucleoside metabolic process [GO:0042278] GO:0001883; GO:0008428; GO:0019213; GO:0042278; GO:0060701 0 0 0 PF01661; A5D9C6 CHOYP_MAF1.1.1 m.29458 sp MAF1_BOVIN 62.281 228 82 3 1 228 1 224 1.27E-88 265 MAF1_BOVIN reviewed Repressor of RNA polymerase III transcription MAF1 homolog MAF1 Bos taurus (Bovine) 260 "negative regulation of transcription from RNA polymerase III promoter [GO:0016480]; transcription, DNA-templated [GO:0006351]; transcription factor TFIIIB complex assembly [GO:0070217]" GO:0000994; GO:0001030; GO:0001031; GO:0001032; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0006351; GO:0016480; GO:0070217 0 0 0 PF09174; B0BN95 CHOYP_HARB1.1.3 m.35791 sp HARB1_RAT 36.744 215 130 3 6 220 18 226 1.27E-35 132 HARB1_RAT reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Rattus norvegicus (Rat) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; B2DFG5 CHOYP_LOC101079404.1.1 m.27501 sp DTHAD_DELSH 30.446 381 239 6 44 406 8 380 1.27E-52 182 DTHAD_DELSH reviewed D-threo-3-hydroxyaspartate dehydratase (D-THA DH) (D-THA dehydratase) (EC 4.3.1.27) (Threo-3-hydroxy-D-aspartate ammonia-lyase) dthadh Delftia sp. (strain HT23) 380 0 GO:0016841; GO:0030170 0 0 0 PF01168;PF14031; B3EWZ5 CHOYP_NEMVEDRAFT_V1G198667.12.15 m.51327 sp MLRP1_ACRMI 32.727 165 99 7 115 271 257 417 1.27E-15 80.5 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B4PD96 CHOYP_LOC100555258.3.3 m.64565 sp CUE_DROYA 40.299 67 30 3 31 96 373 430 1.27E-06 48.1 CUE_DROYA reviewed Protein cueball cue GE20954 Drosophila yakuba (Fruit fly) 644 oogenesis [GO:0048477]; spermatogenesis [GO:0007283] GO:0005509; GO:0005886; GO:0007283; GO:0016021; GO:0048477 0 0 0 PF00058; D2GXS7 CHOYP_LOC100374741.62.83 m.53308 sp TRIM2_AILME 24.806 258 173 7 301 542 492 744 1.27E-14 80.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O13035 CHOYP_LOC100907708.1.1 m.16095 sp SAP_CHICK 23.788 433 246 12 120 478 55 477 1.27E-20 100 SAP_CHICK reviewed Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A; Saposin-B; Saposin-C; Saposin-D] PSAP Gallus gallus (Chicken) 518 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; glycosphingolipid metabolic process [GO:0006687]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216] GO:0001664; GO:0005615; GO:0005737; GO:0005764; GO:0006687; GO:0007193; GO:0008047; GO:0019216; GO:0060736; GO:0060742 0 0 0 PF02199;PF05184;PF03489; O15034 CHOYP_RIMB2.2.5 m.13691 sp RIMB2_HUMAN 37.634 465 237 10 958 1414 167 586 1.27E-75 278 RIMB2_HUMAN reviewed RIMS-binding protein 2 (RIM-BP2) RIMBP2 KIAA0318 RBP2 Homo sapiens (Human) 1052 negative regulation of phosphatase activity [GO:0010923] GO:0005886; GO:0010923; GO:0030054; GO:0045202 0 0 0 PF07653;PF14604; O18404 CHOYP_LOC100114736.1.1 m.18266 sp HCD2_DROME 59.289 253 102 1 28 279 2 254 1.27E-110 323 HCD2_DROME reviewed 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH) scu CG7113 Drosophila melanogaster (Fruit fly) 255 acyl-CoA metabolic process [GO:0006637]; androgen metabolic process [GO:0008209]; ecdysone metabolic process [GO:0008205]; estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; steroid metabolic process [GO:0008202]; tRNA processing [GO:0008033] GO:0003857; GO:0004303; GO:0005739; GO:0005811; GO:0005829; GO:0005875; GO:0006631; GO:0006637; GO:0008033; GO:0008202; GO:0008205; GO:0008209; GO:0008210; GO:0016229; GO:0018454; GO:0030283; GO:0047015; GO:0047022; GO:0047035 0 0 0 PF00106; O70277 CHOYP_BRAFLDRAFT_87312.3.4 m.27361 sp TRIM3_RAT 27.692 130 88 2 62 185 614 743 1.27E-09 61.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75956 CHOYP_BRAFLDRAFT_230475.3.3 m.57104 sp CDKA2_HUMAN 44.538 119 54 3 22 140 20 126 1.27E-25 97.1 CDKA2_HUMAN reviewed Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R) CDK2AP2 DOC1R Homo sapiens (Human) 126 0 0 0 0 0 PF09806; O77487 CHOYP_LOC100054259.1.1 m.12845 sp FUT2_PONPY 28.571 294 181 10 70 351 57 333 1.27E-21 97.4 FUT2_PONPY reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Pongo pygmaeus (Bornean orangutan) 343 protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; O94581 CHOYP_COX12.1.1 m.50262 sp COX12_SCHPO 62.5 72 27 0 96 167 15 86 1.27E-25 96.7 COX12_SCHPO reviewed Cytochrome c oxidase subunit 6B (Cytochrome c oxidase polypeptide VIb) cox12 SPCC1442.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 86 0 GO:0004129; GO:0005634; GO:0005739; GO:0005829 0 0 0 PF02297; O95490 CHOYP_LPHN3.1.1.1 m.143 sp AGRL2_HUMAN 27.915 566 364 17 265 804 550 1097 1.27E-52 203 AGRL2_HUMAN reviewed Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) ADGRL2 KIAA0786 LEC1 LPHH1 LPHN2 Homo sapiens (Human) 1459 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0004930; GO:0007166; GO:0007186; GO:0016021; GO:0016524; GO:0030246 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; P05099 CHOYP_CO6A5.2.6 m.13131 sp MATN1_CHICK 33.744 406 231 15 22 398 33 429 1.27E-49 182 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P06198 CHOYP_MYSP.2.9 m.1763 sp MYSP_SCHMA 58.14 86 35 1 2 87 758 842 1.27E-22 95.5 MYSP_SCHMA reviewed Paramyosin 0 Schistosoma mansoni (Blood fluke) 866 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P0C7U4 CHOYP_NMUR2.1.1 m.62227 sp C3AR_DANRE 25.228 329 213 11 2 323 32 334 1.27E-16 82.8 C3AR_DANRE reviewed C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) c3ar1 Danio rerio (Zebrafish) (Brachydanio rerio) 361 chemotaxis [GO:0006935] GO:0004930; GO:0005886; GO:0006935; GO:0016021 0 0 0 PF00001; P10675 CHOYP_BRAFLDRAFT_127065.7.7 m.57708 sp FAS1_SCHAM 27.129 317 183 11 224 510 210 508 1.27E-18 94.4 FAS1_SCHAM reviewed Fasciclin-1 (Fasciclin I) (FAS I) (FCN) FAS1 Schistocerca americana (American grasshopper) 662 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225 0 0 0 PF02469; P16157 CHOYP_TNKS1.4.5 m.28975 sp ANK1_HUMAN 25.47 691 379 16 163 763 16 660 1.27E-34 146 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17892 CHOYP_BRAFLDRAFT_126555.5.6 m.29638 sp LIPR2_MOUSE 35.73 445 265 10 32 464 31 466 1.27E-81 264 LIPR2_MOUSE reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Cytotoxic T-lymphocyte lipase) (Galactolipase) Pnliprp2 Plrp2 Mus musculus (Mouse) 482 cellular defense response [GO:0006968]; digestion [GO:0007586]; galactolipid catabolic process [GO:0019376]; phospholipid catabolic process [GO:0009395] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0006968; GO:0007586; GO:0009395; GO:0019376; GO:0047372; GO:0047714 0 0 0 PF00151;PF01477; P20825 CHOYP_LOC100374064.2.4 m.18331 sp POL2_DROME 30.435 184 118 4 288 462 131 313 1.27E-17 89.7 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P22105 CHOYP_BRAFLDRAFT_235412.2.2 m.58139 sp TENX_HUMAN 28.247 485 253 37 1 440 300 734 1.27E-23 108 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P22942 CHOYP_DAO.1.1 m.5156 sp OXDA_RABIT 40.762 341 190 6 5 335 1 339 1.27E-86 267 OXDA_RABIT reviewed D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) DAO Oryctolagus cuniculus (Rabbit) 347 D-amino acid metabolic process [GO:0046416] GO:0003884; GO:0005777; GO:0046416; GO:0071949 0 0 0 PF01266; P29590 CHOYP_LOC100371136.4.5 m.53953 sp PML_HUMAN 21.633 245 159 5 606 850 611 822 1.27E-07 59.3 PML_HUMAN reviewed Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) 882 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006915; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0016925; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045892; GO:0045930; GO:0046982; GO:0048146; GO:0048384; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060333; GO:0060444; GO:0070059; GO:0071353; GO:0090398; GO:0097191; GO:1901796; GO:1902187; GO:1904816; GO:2000059; GO:2000779; GO:2001238 0 0 0 PF12126;PF00643; P33316 CHOYP_LOC100183847.2.2 m.17648 sp DUT_HUMAN 71.242 153 44 0 14 166 100 252 1.27E-76 231 DUT_HUMAN reviewed "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)" DUT Homo sapiens (Human) 252 DNA replication [GO:0006260]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside biosynthetic process [GO:0046134] GO:0000287; GO:0004170; GO:0005634; GO:0005654; GO:0005739; GO:0006139; GO:0006226; GO:0006260; GO:0044822; GO:0046081; GO:0046134; GO:0070062 PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. 0 cd07557; PF00692; P35408 CHOYP_PTGER4.2.3 m.32233 sp PE2R4_HUMAN 30.894 369 201 8 51 367 6 372 1.27E-46 169 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P41436 CHOYP_LOC100892236.6.7 m.55464 sp IAP_GVCPM 49.474 95 48 0 801 895 100 194 1.27E-27 116 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P49013 CHOYP_LOC100634060.3.37 m.3661 sp FBP3_STRPU 55.245 143 64 0 1 143 187 329 1.27E-46 161 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P49578 CHOYP_ISCW_ISCW001961.1.1 m.2042 sp ACM3_CHICK 37.61 569 275 11 95 654 115 612 1.27E-115 363 ACM3_CHICK reviewed Muscarinic acetylcholine receptor M3 CHRM3 Gallus gallus (Chicken) 639 "adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway [GO:0007197]; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of smooth muscle contraction [GO:0045987]; regulation of vascular smooth muscle contraction [GO:0003056]; saliva secretion [GO:0046541]; synaptic transmission, cholinergic [GO:0007271]" GO:0003056; GO:0005887; GO:0007197; GO:0007207; GO:0007271; GO:0016907; GO:0030054; GO:0045202; GO:0045211; GO:0045987; GO:0046541 0 0 0 PF00001; P86986 CHOYP_IMSP5.1.2 m.5157 sp IMSP5_RUDPH 28.889 135 92 2 1 135 1 131 1.27E-08 53.1 IMSP5_RUDPH reviewed Insoluble matrix shell protein 5 (IMSP5) 0 Ruditapes philippinarum (Japanese littleneck clam) (Venerupis philippinarum) 135 0 GO:0005509; GO:0005576 0 0 0 PF13202; P98167 CHOYP_SSPO.14.14 m.60298 sp SSPO_BOVIN 29.13 230 142 9 2 214 2732 2957 1.27E-18 91.3 SSPO_BOVIN reviewed SCO-spondin SSPO Bos taurus (Bovine) 5146 cell adhesion [GO:0007155] GO:0005615; GO:0007155; GO:0030414 0 0 0 PF08742;PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q01345 CHOYP_LOC100898717.2.3 m.34275 sp NHEB_ONCMY 42.747 517 270 5 49 565 61 551 1.27E-137 432 NHEB_ONCMY reviewed Na(+)/H(+) exchanger beta (Beta-NHE) (Na(+)/H(+) antiporter) 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 759 regulation of pH [GO:0006885] GO:0006885; GO:0015385; GO:0016021; GO:0016323 0 0 0 PF00999;PF16644; Q06453 CHOYP_AL.1.1 m.36034 sp AL_DROME 49.239 197 73 9 101 285 68 249 1.27E-43 157 AL_DROME reviewed Homeobox protein aristaless al CG3935 Drosophila melanogaster (Fruit fly) 408 "antennal morphogenesis [GO:0048800]; chaeta development [GO:0022416]; elongation of arista core [GO:0035015]; imaginal disc-derived leg morphogenesis [GO:0007480]; leg disc development [GO:0035218]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of Notch signaling pathway [GO:0045747]" GO:0005634; GO:0007480; GO:0022416; GO:0035015; GO:0035218; GO:0043234; GO:0043565; GO:0045747; GO:0045892; GO:0048800 0 0 0 PF00046;PF03826; Q13310 CHOYP_LOC100370010.2.5 m.14470 sp PABP4_HUMAN 70.354 226 64 2 1 226 85 307 1.27E-108 328 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q13395 CHOYP_LOC100700626.1.2 m.5023 sp TARB1_HUMAN 49.219 256 121 4 2 248 1363 1618 1.27E-66 228 TARB1_HUMAN reviewed Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185) TARBP1 TRM3 TRP185 Homo sapiens (Human) 1621 regulation of transcription from RNA polymerase II promoter [GO:0006357]; tRNA methylation [GO:0030488] GO:0003723; GO:0005634; GO:0006357; GO:0016423; GO:0030488 0 0 0 PF00588; Q13946 CHOYP_LOC100648320.1.1 m.48684 sp PDE7A_HUMAN 47.368 475 230 9 26 490 1 465 1.27E-138 419 PDE7A_HUMAN reviewed "High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22)" PDE7A Homo sapiens (Human) 482 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933] GO:0004115; GO:0005829; GO:0006198; GO:0019933; GO:0046872 "PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." 0 0 PF00233; Q14117 CHOYP_LOC100372131.2.2 m.63890 sp DPYS_HUMAN 68.75 288 86 1 46 329 2 289 1.27E-149 433 DPYS_HUMAN reviewed Dihydropyrimidinase (DHP) (DHPase) (EC 3.5.2.2) (Dihydropyrimidine amidohydrolase) (Hydantoinase) DPYS Homo sapiens (Human) 519 beta-alanine metabolic process [GO:0019482]; protein homotetramerization [GO:0051289]; pyrimidine nucleobase catabolic process [GO:0006208]; pyrimidine nucleoside catabolic process [GO:0046135]; thymine catabolic process [GO:0006210]; uracil catabolic process [GO:0006212] GO:0002058; GO:0002059; GO:0004157; GO:0005829; GO:0006208; GO:0006210; GO:0006212; GO:0008270; GO:0016597; GO:0019482; GO:0046135; GO:0051289; GO:0070062 0 0 cd01314; PF01979; Q16829 CHOYP_BRAFLDRAFT_60200.2.3 m.33251 sp DUS7_HUMAN 51.411 319 137 3 25 325 67 385 1.27E-105 319 DUS7_HUMAN reviewed Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2) DUSP7 PYST2 Homo sapiens (Human) 419 activation of MAPK activity [GO:0000187]; MAPK cascade [GO:0000165]; negative regulation of MAP kinase activity [GO:0043407]; peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0000165; GO:0000187; GO:0004725; GO:0005654; GO:0005829; GO:0008138; GO:0017017; GO:0035335; GO:0043407 0 0 0 PF00782;PF00581; Q23157 CHOYP_INX11.2.2 m.58264 sp INX11_CAEEL 27.574 272 169 5 1 246 113 382 1.27E-26 111 INX11_CAEEL reviewed Innexin-11 (Protein opu-11) inx-11 opu-11 W04D2.3 Caenorhabditis elegans 465 ion transport [GO:0006811] GO:0005243; GO:0005886; GO:0005921; GO:0006811; GO:0016021; GO:0055077; GO:1903763 0 0 0 PF00876; Q2KI00 CHOYP_LOC101088499.1.1 m.9433 sp F107B_BOVIN 34.259 108 66 2 164 269 14 118 1.27E-06 50.1 F107B_BOVIN reviewed Protein FAM107B FAM107B Bos taurus (Bovine) 131 0 0 0 0 0 PF06625; Q2YDJ8 CHOYP_LOC100697469.1.1 m.26368 sp KMT5A_BOVIN 33.333 126 65 4 56 164 226 349 1.27E-14 73.9 KMT5A_BOVIN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A SETD8 Bos taurus (Bovine) 352 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0005634; GO:0005694; GO:0006351; GO:0007067; GO:0016279; GO:0018024; GO:0018026; GO:0043516; GO:0051301 0 0 0 PF00856; Q5BIM1 CHOYP_TIF1A.5.8 m.32570 sp TRI45_BOVIN 24.719 178 118 6 20 183 127 302 1.27E-06 53.5 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5BLE8 CHOYP_BRAFLDRAFT_119025.2.3 m.16810 sp RETST_DANRE 50.676 148 69 1 39 186 10 153 1.27E-41 151 RETST_DANRE reviewed "Putative all-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat)" retsat zgc:113107 Danio rerio (Zebrafish) (Brachydanio rerio) 607 0 GO:0016020; GO:0051786 0 0 0 PF01593; Q5ND28 CHOYP_ISCW_ISCW020553.1.2 m.36857 sp SREC_MOUSE 37.705 183 105 7 185 367 213 386 1.27E-22 105 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RJR8 CHOYP_LOC100669963.1.1 m.57300 sp LRC59_RAT 49.807 259 126 3 5 260 10 267 1.27E-74 235 LRC59_RAT reviewed Leucine-rich repeat-containing protein 59 (Protein p34) Lrrc59 Rbp34 Rattus norvegicus (Rat) 307 0 GO:0005635; GO:0005789; GO:0016021; GO:0031090; GO:0042645; GO:0044822 0 0 0 PF13855; Q5RKH6 CHOYP_OS9.1.1 m.54974 sp OS9_RAT 30.844 723 387 19 32 733 31 661 1.27E-96 316 OS9_RAT reviewed Protein OS-9 Os9 Rattus norvegicus (Rat) 666 "ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein retention in ER lumen [GO:0006621]; protein targeting [GO:0006605]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; retrograde protein transport, ER to cytosol [GO:0030970]" GO:0000836; GO:0001948; GO:0002020; GO:0005783; GO:0005788; GO:0006605; GO:0006621; GO:0030246; GO:0030433; GO:0030970; GO:0042787; GO:1904153 0 0 0 PF07915; Q5VXU9 CHOYP_LOC100923236.1.1 m.49345 sp CI084_HUMAN 23.699 519 338 16 778 1245 582 1093 1.27E-23 113 CI084_HUMAN reviewed Uncharacterized protein C9orf84 C9orf84 Homo sapiens (Human) 1444 0 0 0 0 0 0 Q5VYJ5 CHOYP_BRAFLDRAFT_66659.2.2 m.5676 sp MALR1_HUMAN 35.052 97 53 5 2 89 888 983 1.27E-09 57.8 MALR1_HUMAN reviewed MAM and LDL-receptor class A domain-containing protein 1 MALRD1 C10orf112 DIET1 Homo sapiens (Human) 2156 cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858] GO:0016021; GO:0030659; GO:0042632; GO:0070858 0 0 cd06263; PF00008;PF00057;PF00629; Q61425 CHOYP_LOC575203.4.6 m.16404 sp HCDH_MOUSE 68.482 257 79 2 24 278 29 285 1.27E-121 353 HCDH_MOUSE reviewed "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)" Hadh Hadhsc Mschad Schad Mus musculus (Mouse) 314 fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to insulin [GO:0032868] GO:0003857; GO:0005654; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006635; GO:0014823; GO:0032868; GO:0042493; GO:0046676; GO:0070403 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00725;PF02737; Q69Z37 CHOYP_LOC100368821.5.7 m.44019 sp SAM9L_MOUSE 33.564 289 142 9 730 1000 194 450 1.27E-30 134 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6DED0 CHOYP_BRAFLDRAFT_274974.1.1 m.56783 sp TR1L1_XENLA 51.064 376 174 6 1 372 1 370 1.27E-128 377 TR1L1_XENLA reviewed Translocating chain-associated membrane protein 1-like 1 tram1l1 Xenopus laevis (African clawed frog) 373 protein transport [GO:0015031] GO:0005789; GO:0015031; GO:0016021 0 0 0 PF08390;PF03798; Q6IQ97 CHOYP_LOC100708853.2.3 m.32249 sp RBM41_DANRE 54.167 72 33 0 3 74 2 73 1.27E-21 97.4 RBM41_DANRE reviewed RNA-binding protein 4.1 (RNA-binding motif protein 4.1) rbm4.1 rbm4 Danio rerio (Zebrafish) (Brachydanio rerio) 419 0 GO:0000166; GO:0003723; GO:0005634; GO:0008270 0 0 0 PF00076;PF00098; Q6P9K8 CHOYP_LOC100377359.1.1 m.13136 sp CSKI1_MOUSE 33.333 144 78 7 359 490 127 264 1.27E-07 58.2 CSKI1_MOUSE reviewed Caskin-1 (CASK-interacting protein 1) Caskin1 Kiaa1306 Mus musculus (Mouse) 1431 signal transduction [GO:0007165] GO:0005737; GO:0007165 0 0 0 PF12796;PF16632;PF00536;PF07653; Q6TLF6 CHOYP_LOC754557.2.2 m.22904 sp RGN_DANRE 41.06 302 166 5 1 300 4 295 1.27E-68 218 RGN_DANRE reviewed Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) rgn zgc:92078 Danio rerio (Zebrafish) (Brachydanio rerio) 295 cellular calcium ion homeostasis [GO:0006874]; L-ascorbic acid biosynthetic process [GO:0019853]; positive regulation of ATPase activity [GO:0032781]; regulation of calcium-mediated signaling [GO:0050848] GO:0004341; GO:0005509; GO:0005634; GO:0005737; GO:0006874; GO:0008270; GO:0019853; GO:0030234; GO:0032781; GO:0050848 PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. 0 0 PF08450; Q7YW31 CHOYP_OX2R.2.3 m.25183 sp CTR1_OCTVU 23.214 336 227 13 16 342 41 354 1.27E-07 56.6 CTR1_OCTVU reviewed Cephalotocin receptor 1 (OC/CE-R 1) (OT/VP superfamily peptide receptor 1) CTR1 Octopus vulgaris (Common octopus) 397 G-protein coupled receptor signaling pathway [GO:0007186] GO:0005000; GO:0005886; GO:0007186; GO:0016021; GO:0016500 0 0 0 PF00001; Q89703 CHOYP_CRE_11685.2.2 m.12763 sp POL_CSVMV 24.781 456 284 17 156 585 223 645 1.27E-14 81.3 POL_CSVMV reviewed Putative enzymatic polyprotein [Includes: Protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] ORF 3 Cassava vein mosaic virus (CsVMV) 652 DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0046872 0 0 0 PF02160;PF00078; Q8MJU1 CHOYP_SPT20.1.1 m.35909 sp CASP3_FELCA 32.09 134 72 5 12 142 44 161 1.27E-09 58.5 CASP3_FELCA reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Felis catus (Cat) (Felis silvestris catus) 277 erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182] GO:0005737; GO:0030182; GO:0030216; GO:0030218; GO:0097194; GO:0097200 0 0 0 0 Q8TER0 CHOYP_LOC574757.5.9 m.32028 sp SNED1_HUMAN 46.259 294 141 3 21 313 26 303 1.27E-71 265 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q96B26 CHOYP_LOC100373657.1.1 m.10366 sp EXOS8_HUMAN 52.252 222 105 1 1 221 53 274 1.27E-81 247 EXOS8_HUMAN reviewed Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9) EXOSC8 OIP2 RRP43 Homo sapiens (Human) 276 "exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; regulation of mRNA stability [GO:0043488]; rRNA processing [GO:0006364]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" GO:0000176; GO:0000177; GO:0000178; GO:0000467; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0017091; GO:0034427; GO:0034473; GO:0034475; GO:0034476; GO:0043488; GO:0043928; GO:0071028; GO:0071035; GO:0071038; GO:0071042 0 0 0 PF01138;PF03725; Q96II8 CHOYP_LRCH3.1.4 m.30029 sp LRCH3_HUMAN 59.524 126 51 0 1 126 153 278 1.27E-41 162 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q96M20 CHOYP_SMP_147320.1.1 m.27463 sp CNBD2_HUMAN 24.583 240 150 5 8 246 82 291 1.27E-11 68.9 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96MM6 CHOYP_HSPA12A.20.27 m.55564 sp HS12B_HUMAN 31.163 645 366 18 8 595 61 684 1.27E-90 296 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_HSPA12B.1.1 m.36165 sp HS12B_HUMAN 26.649 379 207 9 206 525 32 398 1.27E-24 111 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_LOC100899882.3.3 m.56642 sp HS12B_HUMAN 29.584 649 355 22 31 602 62 685 1.27E-74 254 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96QU1 CHOYP_LOC100369355.1.1 m.13122 sp PCD15_HUMAN 30.201 447 249 19 122 544 615 1022 1.27E-31 137 PCD15_HUMAN reviewed Protocadherin-15 PCDH15 USH1F Homo sapiens (Human) 1955 equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0001750; GO:0005509; GO:0005615; GO:0005886; GO:0007156; GO:0007605; GO:0016021; GO:0032420; GO:0045202; GO:0045494; GO:0048839; GO:0050953; GO:0050957; GO:0070062 0 0 0 PF00028; Q9CQR5 CHOYP_BRAFLDRAFT_219108.1.1 m.41664 sp ZMAT5_MOUSE 40.571 175 99 2 18 192 1 170 1.27E-39 135 ZMAT5_MOUSE reviewed Zinc finger matrin-type protein 5 (U11/U12 small nuclear ribonucleoprotein 20 kDa protein) (U11/U12 snRNP 20 kDa protein) Zmat5 D11Bwg1548e Mus musculus (Mouse) 170 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0005689; GO:0006397; GO:0008270; GO:0008380 0 0 0 PF00642;PF06220; Q9CXS4 CHOYP_LOC100366455.2.3 m.25037 sp CENPV_MOUSE 61.719 128 48 1 8 134 125 252 1.27E-56 179 CENPV_MOUSE reviewed Centromere protein V (CENP-V) (Proline-rich protein 6) Cenpv Prr6 Mus musculus (Mouse) 252 ameboidal-type cell migration [GO:0001667]; cell division [GO:0051301]; centromere complex assembly [GO:0034508]; metabolic process [GO:0008152]; mitotic nuclear division [GO:0007067]; pericentric heterochromatin assembly [GO:0031508]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044] GO:0000776; GO:0000777; GO:0001667; GO:0005634; GO:0005654; GO:0005737; GO:0007067; GO:0008152; GO:0015630; GO:0016846; GO:0031508; GO:0032467; GO:0033044; GO:0034508; GO:0051233; GO:0051301 0 0 0 PF04828; Q9CY21 CHOYP_LOC581711.1.1 m.14276 sp WBS22_MOUSE 61.957 276 101 3 6 278 7 281 1.27E-125 362 WBS22_MOUSE reviewed Probable 18S rRNA (guanine-N(7))-methyltransferase (EC 2.1.1.-) (Bud site selection protein 23 homolog) (Williams-Beuren syndrome chromosomal region 22 protein homolog) Wbscr22 Mus musculus (Mouse) 281 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0006364; GO:0008168; GO:0016569; GO:0044822 0 0 0 PF08241;PF12589; Q9D9R9 CHOYP_VWDE.13.13 m.58226 sp F186A_MOUSE 36.624 628 255 31 546 1068 377 966 1.27E-24 116 F186A_MOUSE reviewed Protein FAM186A FAM186A Gm920 Mus musculus (Mouse) 1790 0 0 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_69390.2.2 m.38096 sp TRIM2_MOUSE 23.221 267 182 10 28 280 485 742 1.27E-08 59.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NRK6 CHOYP_NEMVEDRAFT_V1G168501.1.1 m.34006 sp ABCBA_HUMAN 52.465 284 132 2 80 362 130 411 1.27E-90 290 ABCBA_HUMAN reviewed "ATP-binding cassette sub-family B member 10, mitochondrial (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2)" ABCB10 Homo sapiens (Human) 738 transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005524; GO:0005743; GO:0006810; GO:0032592; GO:0042626; GO:0055085 0 0 0 PF00664;PF00005; Q9QZK8 CHOYP_DICPUDRAFT_157792.1.1 m.40741 sp DNS2A_RAT 34.524 168 106 3 19 183 20 186 1.27E-23 99.4 DNS2A_RAT reviewed Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) Dnase2 Dnase2a Dnl2 Rattus norvegicus (Rat) 350 apoptotic DNA fragmentation [GO:0006309]; erythrocyte differentiation [GO:0030218] GO:0004520; GO:0004531; GO:0005622; GO:0005764; GO:0006309; GO:0030218; GO:0070062 0 0 0 PF03265; Q9R101 CHOYP_LIPS.1.2 m.16070 sp LIPS_ICTTR 44.082 490 253 7 7 481 5 488 1.27E-137 430 LIPS_ICTTR reviewed Hormone-sensitive lipase (HSL) (EC 3.1.1.79) LIPE Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) 763 cholesterol metabolic process [GO:0008203]; lipid catabolic process [GO:0016042]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation from RNA polymerase I promoter [GO:0006361]; triglyceride catabolic process [GO:0019433] GO:0005634; GO:0005737; GO:0005739; GO:0005811; GO:0005829; GO:0005901; GO:0006361; GO:0006363; GO:0008203; GO:0016042; GO:0016298; GO:0019433; GO:0033878; GO:0042134 PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. 0 0 PF07859;PF06350; Q9SS90 CHOYP_BRAFLDRAFT_106513.1.1 m.38663 sp RGLG1_ARATH 46.763 278 129 5 63 324 128 402 1.27E-79 253 RGLG1_ARATH reviewed E3 ubiquitin-protein ligase RGLG1 (EC 6.3.2.-) (RING domain ligase 1) RGLG1 At3g01650 F4P13.19 Arabidopsis thaliana (Mouse-ear cress) 489 negative regulation of response to water deprivation [GO:0080148] GO:0004842; GO:0005886; GO:0008270; GO:0016874; GO:0080148 0 0 0 PF07002; Q9VUL9 CHOYP_TSP_02555.1.1 m.37032 sp FUCTA_DROME 30.081 246 158 7 92 331 202 439 1.27E-24 107 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q9W7R6 CHOYP_SOX1.1.1 m.35959 sp SOX14_CHICK 53.275 229 85 8 33 252 6 221 1.27E-63 202 SOX14_CHICK reviewed Transcription factor SOX-14 (SRY-related protein CH60) SOX14 Gallus gallus (Chicken) 240 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0006351; GO:0043565; GO:0045892 0 0 0 PF00505;PF12336; Q9WV72 CHOYP_TVAG_388180.4.8 m.32585 sp ASB3_MOUSE 36.478 159 80 6 31 186 126 266 1.27E-20 91.7 ASB3_MOUSE reviewed Ankyrin repeat and SOCS box protein 3 (ASB-3) Asb3 Mus musculus (Mouse) 525 intracellular signal transduction [GO:0035556] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0031625; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF13606;PF07525; Q9WVS8 CHOYP_MAPK7.1.1 m.33213 sp MK07_MOUSE 55.882 374 161 2 22 392 40 412 1.27E-142 449 MK07_MOUSE reviewed Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) Mapk7 Bmk1 Erk5 Mus musculus (Mouse) 806 cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to transforming growth factor beta stimulus [GO:0071560]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of ERK5 cascade [GO:0070377]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NFAT protein import into nucleus [GO:0051534]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of response to cytokine stimulus [GO:0060761]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; protein phosphorylation [GO:0006468]; regulation of angiogenesis [GO:0045765] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006468; GO:0007049; GO:0016605; GO:0018105; GO:0030154; GO:0034115; GO:0036003; GO:0043066; GO:0043407; GO:0045765; GO:0045944; GO:0051019; GO:0051247; GO:0051534; GO:0060761; GO:0070301; GO:0070377; GO:0071363; GO:0071499; GO:0071560; GO:1902176; GO:2000352; GO:2001240 0 0 0 PF00069; A2AAJ9 CHOYP_PHUM_PHUM226120.5.7 m.43554 sp OBSCN_MOUSE 32.8 125 79 2 17 138 89 211 1.28E-12 74.3 OBSCN_MOUSE reviewed Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Obscn Gm878 Mus musculus (Mouse) 8891 cell differentiation [GO:0030154]; mitophagy in response to mitochondrial depolarization [GO:0098779]; multicellular organism development [GO:0007275]; regulation of Rho protein signal transduction [GO:0035023] GO:0004674; GO:0005089; GO:0005524; GO:0005863; GO:0007275; GO:0030018; GO:0030154; GO:0030506; GO:0031430; GO:0031432; GO:0035023; GO:0098779 0 0 0 PF00041;PF07679;PF00612;PF00069;PF00621; A6NFN9 CHOYP_LOC587133.1.1 m.61280 sp ANKUB_HUMAN 35.925 373 223 6 11 380 1 360 1.28E-69 238 ANKUB_HUMAN reviewed Protein ANKUB1 (Ankyrin repeat and ubiquitin domain-containing 1) ANKUB1 C3orf16 Homo sapiens (Human) 424 0 0 0 0 0 PF00240; C8YR32 CHOYP_LOC100175334.1.2 m.56515 sp LOXH1_MOUSE 31.818 594 374 16 902 1489 189 757 1.28E-75 282 LOXH1_MOUSE reviewed Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) 2068 detection of mechanical stimulus [GO:0050982]; sensory perception of sound [GO:0007605] GO:0005262; GO:0007605; GO:0016020; GO:0032420; GO:0050982 0 0 0 PF01477; F1R983 CHOYP_RBBP8.1.1 m.17806 sp COM1_DANRE 47.115 104 51 2 741 844 544 643 1.28E-20 100 COM1_DANRE reviewed DNA endonuclease RBBP8 (EC 3.1.-.-) rbbp8 zgc:113143 Danio rerio (Zebrafish) (Brachydanio rerio) 651 cell division [GO:0051301]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067] GO:0000724; GO:0003677; GO:0004519; GO:0005634; GO:0007067; GO:0010792; GO:0051301; GO:0051321 0 0 0 PF10482;PF08573; O08762 CHOYP_LOC100891258.1.1 m.55507 sp NETR_MOUSE 37.16 331 189 6 29 351 166 485 1.28E-66 229 NETR_MOUSE reviewed Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12) Prss12 Bssp3 Mus musculus (Mouse) 761 exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202 0 0 cd00190; PF00051;PF00530;PF00089; O35207 CHOYP_LOC590648.1.1 m.62966 sp CDKA1_MOUSE 64.516 31 11 0 117 147 59 89 1.28E-08 53.1 CDKA1_MOUSE reviewed Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor) Cdk2ap1 Cdkap1 Doc1 Mus musculus (Mouse) 114 cell cycle [GO:0007049]; face morphogenesis [GO:0060325]; in utero embryonic development [GO:0001701]; positive regulation of protein phosphorylation [GO:0001934] GO:0001701; GO:0001934; GO:0005634; GO:0007049; GO:0048471; GO:0060325; GO:0070182 0 0 0 PF09806; O35737 CHOYP_NEMVEDRAFT_V1G115454.1.2 m.40805 sp HNRH1_MOUSE 68.235 85 27 0 239 323 280 364 1.28E-31 128 HNRH1_MOUSE reviewed "Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]" Hnrnph1 Hnrph Hnrph1 Mus musculus (Mouse) 449 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005654; GO:0005737; GO:0006397; GO:0008380; GO:0016020; GO:0043484; GO:0044822; GO:0071013 0 0 0 PF00076;PF08080; O54990 CHOYP_PROM1.1.3 m.16674 sp PROM1_MOUSE 24.678 466 276 18 55 476 54 488 1.28E-24 111 PROM1_MOUSE reviewed Prominin-1 (Antigen AC133 homolog) (Prominin-like protein 1) (CD antigen CD133) Prom1 Prom Proml1 Mus musculus (Mouse) 867 camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; glomerular visceral epithelial cell differentiation [GO:0072112]; photoreceptor cell maintenance [GO:0045494]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042] GO:0001750; GO:0005615; GO:0005783; GO:0005793; GO:0005886; GO:0005887; GO:0005902; GO:0005903; GO:0005929; GO:0009986; GO:0010842; GO:0016324; GO:0031528; GO:0031982; GO:0032420; GO:0042622; GO:0042805; GO:0042995; GO:0043231; GO:0045296; GO:0045494; GO:0060042; GO:0060219; GO:0070062; GO:0071914; GO:0072112; GO:0072139; GO:2000768 0 0 0 PF05478; O60494 CHOYP_DANA_GF23226.1.1 m.56574 sp CUBN_HUMAN 26.638 687 380 26 38 719 1396 1963 1.28E-45 182 CUBN_HUMAN reviewed Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) 3623 cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; tissue homeostasis [GO:0001894]; vitamin D metabolic process [GO:0042359] GO:0001894; GO:0004872; GO:0005215; GO:0005509; GO:0005765; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0005905; GO:0006898; GO:0008203; GO:0009235; GO:0010008; GO:0015031; GO:0015889; GO:0016020; GO:0016324; GO:0030139; GO:0031232; GO:0031419; GO:0031526; GO:0042157; GO:0042359; GO:0042803; GO:0042953; GO:0043202; GO:0070062 0 0 0 PF00431;PF00008;PF12947;PF07645; O70165 CHOYP_LOC100639931.1.1 m.29445 sp FCN1_MOUSE 42.64 197 105 5 155 343 136 332 1.28E-39 145 FCN1_MOUSE reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Mus musculus (Mouse) 334 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 secretion [GO:2000484]" GO:0001867; GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0046872; GO:0097367; GO:2000484 0 0 0 PF01391;PF00147; O76537 CHOYP_LOC100376802.2.2 m.60631 sp PGRP_TRINI 41.071 168 96 1 101 268 15 179 1.28E-44 158 PGRP_TRINI reviewed Peptidoglycan recognition protein PGRP Trichoplusia ni (Cabbage looper) 182 innate immune response [GO:0045087]; peptidoglycan catabolic process [GO:0009253] GO:0008270; GO:0008745; GO:0009253; GO:0045087 0 0 cd06583; PF01510; O88281 CHOYP_MEGF6.53.59 m.55485 sp MEGF6_RAT 40.468 299 159 12 168 463 912 1194 1.28E-38 156 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P05300 CHOYP_LAMP1.2.3 m.16422 sp LAMP1_CHICK 28.093 388 204 16 333 685 67 414 1.28E-23 107 LAMP1_CHICK reviewed Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (Lysosome membrane glycoprotein LEP100) LAMP1 Gallus gallus (Chicken) 414 0 GO:0005765; GO:0005770; GO:0005886; GO:0010008; GO:0016020; GO:0016021 0 0 0 PF01299; P07686 CHOYP_CPIPJ_CPIJ016910.1.1 m.62713 sp HEXB_HUMAN 43.366 505 240 9 362 863 90 551 1.28E-136 424 HEXB_HUMAN reviewed Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) 556 astrocyte cell migration [GO:0043615]; cellular calcium ion homeostasis [GO:0006874]; cellular protein metabolic process [GO:0044267]; chondroitin sulfate catabolic process [GO:0030207]; ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; hyaluronan catabolic process [GO:0030214]; keratan sulfate catabolic process [GO:0042340]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501] GO:0001501; GO:0001669; GO:0004563; GO:0006687; GO:0006689; GO:0006874; GO:0007040; GO:0007341; GO:0007605; GO:0007626; GO:0008049; GO:0008360; GO:0008375; GO:0008654; GO:0009313; GO:0016020; GO:0019915; GO:0030207; GO:0030214; GO:0042340; GO:0042552; GO:0042582; GO:0042803; GO:0043202; GO:0043615; GO:0044267; GO:0045944; GO:0046982; GO:0048477; GO:0050885; GO:0070062 0 0 0 PF00728;PF14845; P08228 CHOYP_ISCW_ISCW008219.1.2 m.46822 sp SODC_MOUSE 70.588 153 45 0 4 156 2 154 1.28E-74 223 SODC_MOUSE reviewed Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) Sod1 Mus musculus (Mouse) 154 activation of MAPK activity [GO:0000187]; aging [GO:0007568]; anterograde axonal transport [GO:0008089]; auditory receptor cell stereocilium organization [GO:0060088]; cell aging [GO:0007569]; cellular iron ion homeostasis [GO:0006879]; cellular response to ATP [GO:0071318]; cellular response to cadmium ion [GO:0071276]; cellular response to potassium ion [GO:0035865]; embryo implantation [GO:0007566]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of neuron apoptotic process [GO:0043524]; neurofilament cytoskeleton organization [GO:0060052]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of protein kinase activity [GO:0045859]; relaxation of vascular smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to amphetamine [GO:0001975]; response to antibiotic [GO:0046677]; response to antipsychotic drug [GO:0097332]; response to axon injury [GO:0048678]; response to carbon monoxide [GO:0034465]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to nutrient levels [GO:0031667]; response to organic substance [GO:0010033]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]; response to superoxide [GO:0000303]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; transmission of nerve impulse [GO:0019226] GO:0000187; GO:0000302; GO:0000303; GO:0001541; GO:0001819; GO:0001895; GO:0001975; GO:0002262; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005758; GO:0005764; GO:0005777; GO:0005829; GO:0005886; GO:0006749; GO:0006801; GO:0006879; GO:0006979; GO:0007283; GO:0007566; GO:0007568; GO:0007569; GO:0007605; GO:0007626; GO:0008089; GO:0008090; GO:0008217; GO:0008270; GO:0009408; GO:0010033; GO:0019226; GO:0019430; GO:0030346; GO:0031012; GO:0031045; GO:0031410; GO:0031667; GO:0032287; GO:0032839; GO:0032930; GO:0034465; GO:0035865; GO:0040014; GO:0042493; GO:0042542; GO:0042554; GO:0042802; GO:0043025; GO:0043066; GO:0043085; GO:0043087; GO:0043209; GO:0043234; GO:0043524; GO:0045471; GO:0045541; GO:0045859; GO:0046677; GO:0046688; GO:0046716; GO:0048365; GO:0048678; GO:0050665; GO:0051087; GO:0051881; GO:0060047; GO:0060052; GO:0060087; GO:0060088; GO:0070062; GO:0071276; GO:0071318; GO:0072593; GO:0097332; GO:1902177; GO:1904115 0 0 cd00305; PF00080; P08228 CHOYP_ISCW_ISCW008219.2.2 m.63442 sp SODC_MOUSE 70.588 153 45 0 4 156 2 154 1.28E-74 223 SODC_MOUSE reviewed Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) Sod1 Mus musculus (Mouse) 154 activation of MAPK activity [GO:0000187]; aging [GO:0007568]; anterograde axonal transport [GO:0008089]; auditory receptor cell stereocilium organization [GO:0060088]; cell aging [GO:0007569]; cellular iron ion homeostasis [GO:0006879]; cellular response to ATP [GO:0071318]; cellular response to cadmium ion [GO:0071276]; cellular response to potassium ion [GO:0035865]; embryo implantation [GO:0007566]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of neuron apoptotic process [GO:0043524]; neurofilament cytoskeleton organization [GO:0060052]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of protein kinase activity [GO:0045859]; relaxation of vascular smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to amphetamine [GO:0001975]; response to antibiotic [GO:0046677]; response to antipsychotic drug [GO:0097332]; response to axon injury [GO:0048678]; response to carbon monoxide [GO:0034465]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to nutrient levels [GO:0031667]; response to organic substance [GO:0010033]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]; response to superoxide [GO:0000303]; retina homeostasis [GO:0001895]; retrograde axonal transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; transmission of nerve impulse [GO:0019226] GO:0000187; GO:0000302; GO:0000303; GO:0001541; GO:0001819; GO:0001895; GO:0001975; GO:0002262; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005758; GO:0005764; GO:0005777; GO:0005829; GO:0005886; GO:0006749; GO:0006801; GO:0006879; GO:0006979; GO:0007283; GO:0007566; GO:0007568; GO:0007569; GO:0007605; GO:0007626; GO:0008089; GO:0008090; GO:0008217; GO:0008270; GO:0009408; GO:0010033; GO:0019226; GO:0019430; GO:0030346; GO:0031012; GO:0031045; GO:0031410; GO:0031667; GO:0032287; GO:0032839; GO:0032930; GO:0034465; GO:0035865; GO:0040014; GO:0042493; GO:0042542; GO:0042554; GO:0042802; GO:0043025; GO:0043066; GO:0043085; GO:0043087; GO:0043209; GO:0043234; GO:0043524; GO:0045471; GO:0045541; GO:0045859; GO:0046677; GO:0046688; GO:0046716; GO:0048365; GO:0048678; GO:0050665; GO:0051087; GO:0051881; GO:0060047; GO:0060052; GO:0060087; GO:0060088; GO:0070062; GO:0071276; GO:0071318; GO:0072593; GO:0097332; GO:1902177; GO:1904115 0 0 cd00305; PF00080; P16157 CHOYP_TVAG_168010.39.45 m.60763 sp ANK1_HUMAN 32.237 760 510 2 46 805 32 786 1.28E-109 382 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20825 CHOYP_LOC578054.5.7 m.28466 sp POL2_DROME 47.244 127 61 1 9 135 502 622 1.28E-30 118 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P22373 CHOYP_LOC575748.1.4 m.1538 sp DPOM_CLAPU 24.479 384 177 16 850 1200 619 922 1.28E-10 70.1 DPOM_CLAPU reviewed Probable DNA polymerase (EC 2.7.7.7) 0 Claviceps purpurea (Ergot fungus) (Sphacelia segetum) 1063 DNA replication [GO:0006260] GO:0000166; GO:0003677; GO:0003887; GO:0005739; GO:0006260; GO:0008408 0 0 0 PF03175; P23229 CHOYP_ITA7.1.1 m.1060 sp ITA6_HUMAN 30.058 1201 646 51 27 1120 1 1114 1.28E-128 424 ITA6_HUMAN reviewed Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)] ITGA6 Homo sapiens (Human) 1130 amelogenesis [GO:0097186]; brown fat cell differentiation [GO:0050873]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to extracellular stimulus [GO:0031668]; digestive tract development [GO:0048565]; ectodermal cell differentiation [GO:0010668]; extracellular matrix organization [GO:0030198]; filopodium assembly [GO:0046847]; hemidesmosome assembly [GO:0031581]; integrin-mediated signaling pathway [GO:0007229]; leukocyte migration [GO:0050900]; nail development [GO:0035878]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cell migration [GO:0030335]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; renal system development [GO:0072001]; skin development [GO:0043588] GO:0005604; GO:0005886; GO:0005913; GO:0005925; GO:0007044; GO:0007160; GO:0007229; GO:0008305; GO:0009897; GO:0009925; GO:0009986; GO:0010668; GO:0022409; GO:0030056; GO:0030198; GO:0030335; GO:0031581; GO:0031589; GO:0031668; GO:0033627; GO:0035878; GO:0042327; GO:0043065; GO:0043547; GO:0043588; GO:0045944; GO:0046847; GO:0046872; GO:0048565; GO:0050873; GO:0050900; GO:0072001; GO:0097186; GO:0098641; GO:2001237 0 0 0 PF01839;PF08441; P35408 CHOYP_PI2R.2.4 m.26157 sp PE2R4_HUMAN 30.473 338 189 5 1 296 1 334 1.28E-36 141 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P35789 CHOYP_LOC100537510.1.1 m.51725 sp ZNF93_HUMAN 36.364 231 137 6 40 266 254 478 1.28E-34 135 ZNF93_HUMAN reviewed Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34) ZNF93 ZNF505 Homo sapiens (Human) 620 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transposon integration [GO:0070895]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0008270; GO:0045892; GO:0070895 0 0 cd07765; PF01352;PF00096;PF13912; P52735 CHOYP_VAV2.2.3 m.50395 sp VAV2_HUMAN 43.485 637 328 12 88 711 1 618 1.28E-166 504 VAV2_HUMAN reviewed Guanine nucleotide exchange factor VAV2 (VAV-2) VAV2 Homo sapiens (Human) 878 angiogenesis [GO:0001525]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of blood coagulation [GO:0030193]; regulation of cell size [GO:0008361]; regulation of gene expression [GO:0010468]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005085; GO:0005089; GO:0005829; GO:0005886; GO:0007165; GO:0007264; GO:0008361; GO:0010468; GO:0016477; GO:0030032; GO:0030168; GO:0030193; GO:0035023; GO:0038095; GO:0038096; GO:0043065; GO:0043087; GO:0043552; GO:0046872; GO:0048010; GO:0048013; GO:0051056 0 0 0 PF00130;PF11971;PF00169;PF00621;PF00017;PF07653; P55210 CHOYP_LOC100471992.1.1 m.29004 sp CASP7_HUMAN 32.374 139 73 6 1 121 166 301 1.28E-10 60.5 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P61859 CHOYP_CALM.36.50 m.52073 sp CALM_NEUCR 43.357 143 75 2 13 154 12 149 1.28E-34 121 CALM_NEUCR reviewed Calmodulin (CaM) cmd-1 cmd1 94C8.160 NCU04120 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 149 0 GO:0005509 0 0 0 PF13499; Q02357 CHOYP_TVAG_123950.18.31 m.39671 sp ANK1_MOUSE 38.261 230 142 0 2 231 178 407 1.28E-42 157 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q02645 CHOYP_ADD.5.5 m.55701 sp HTS_DROME 59.677 62 25 0 1 62 541 602 1.28E-17 82 HTS_DROME reviewed Protein hu-li tai shao (Adducin-like protein) hts CG9325 Drosophila melanogaster (Fruit fly) 1156 "actin filament bundle organization [GO:0061572]; adult somatic muscle development [GO:0007527]; axon guidance [GO:0007411]; centrosome organization [GO:0051297]; cystoblast division [GO:0007282]; female germ-line cyst formation [GO:0048135]; female germline ring canal formation, actin assembly [GO:0008302]; fusome organization [GO:0045478]; germarium-derived oocyte fate determination [GO:0007294]; germ-line cyst formation [GO:0048134]; locomotion involved in locomotory behavior [GO:0031987]; meiotic spindle organization [GO:0000212]; neuron cellular homeostasis [GO:0070050]; oogenesis [GO:0048477]; ovarian fusome organization [GO:0030723]; photoreceptor cell axon guidance [GO:0072499]; sarcomere organization [GO:0045214]; spectrosome organization [GO:0030721]; testicular fusome organization [GO:0030724]" GO:0000212; GO:0005737; GO:0005811; GO:0005856; GO:0005886; GO:0007282; GO:0007294; GO:0007411; GO:0007527; GO:0008302; GO:0016328; GO:0030721; GO:0030723; GO:0030724; GO:0031987; GO:0035183; GO:0045169; GO:0045170; GO:0045172; GO:0045214; GO:0045478; GO:0048134; GO:0048135; GO:0048477; GO:0051297; GO:0061572; GO:0070050; GO:0072499 0 0 0 PF00596; Q059Y8 CHOYP_LOC590762.2.2 m.23590 sp DCST1_MOUSE 38.961 77 47 0 88 164 114 190 1.28E-09 59.3 DCST1_MOUSE reviewed DC-STAMP domain-containing protein 1 Dcst1 Mus musculus (Mouse) 732 0 GO:0016021; GO:0046872 0 0 0 PF07782; Q06852 CHOYP_GSPATT00029150001.1.2 m.20749 sp SLAP1_CLOTH 57.655 307 86 24 10 284 1449 1743 1.28E-22 106 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q06852 CHOYP_contig_027435 m.31151 sp SLAP1_CLOTH 31.401 414 211 17 1 359 1563 1958 1.28E-15 83.6 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0MQI9 CHOYP_BRAFLDRAFT_115771.1.2 m.30525 sp NDUV2_PANTR 67.094 234 70 3 41 272 21 249 1.28E-113 330 NDUV2_PANTR reviewed "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit)" NDUFV2 Pan troglodytes (Chimpanzee) 249 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" GO:0005747; GO:0006120; GO:0008137; GO:0046872; GO:0051537 0 0 0 0 Q0P5B7 CHOYP_AAAD.3.4 m.35515 sp AAAD_BOVIN 34.574 376 223 13 14 377 10 374 1.28E-52 183 AAAD_BOVIN reviewed Arylacetamide deacetylase (EC 3.1.1.3) AADAC Bos taurus (Bovine) 399 metabolic process [GO:0008152]; positive regulation of triglyceride catabolic process [GO:0010898] GO:0004806; GO:0005789; GO:0008152; GO:0010898; GO:0016021; GO:0017171; GO:0031090 0 0 0 PF07859; Q0VAA2 CHOYP_BRAFLDRAFT_66304.3.3 m.37720 sp LR74A_HUMAN 27.962 422 275 9 17 432 82 480 1.28E-38 150 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q12955 CHOYP_LOC754035.5.6 m.52365 sp ANK3_HUMAN 30.607 758 496 2 195 923 61 817 1.28E-108 374 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q32LQ6 CHOYP_BRAFLDRAFT_277055.2.2 m.18712 sp MFSD1_DANRE 58.75 240 99 0 1 240 222 461 1.28E-88 274 MFSD1_DANRE reviewed Major facilitator superfamily domain-containing protein 1 mfsd1 zgc:123187 Danio rerio (Zebrafish) (Brachydanio rerio) 461 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q32PP1 CHOYP_RGD1564036.1.1 m.8256 sp CE045_DANRE 47.321 112 56 2 1 112 1 109 1.28E-23 103 CE045_DANRE reviewed UPF0544 protein C5orf45 homolog zgc:123335 Danio rerio (Zebrafish) (Brachydanio rerio) 395 0 0 0 0 0 PF15749; Q3SZ90 CHOYP_RL13A.3.3 m.44529 sp RL13A_BOVIN 70.769 130 38 0 1 130 22 151 1.28E-65 201 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q3SZJ4 CHOYP_LOC100120078.1.1 m.62346 sp PTGR1_BOVIN 54.804 281 118 9 47 324 1 275 1.28E-92 281 PTGR1_BOVIN reviewed Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) PTGR1 LTB4DH Bos taurus (Bovine) 329 0 GO:0005737; GO:0008270; GO:0032440; GO:0036132; GO:0047522 0 0 0 PF00107; Q460N5 CHOYP_PARP14.2.22 m.16380 sp PAR14_HUMAN 30.256 390 247 12 29 405 809 1186 1.28E-36 146 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q502M6 CHOYP_TVAG_123950.19.31 m.42719 sp ANR29_DANRE 38.65 163 100 0 1 163 58 220 1.28E-34 126 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q57951 CHOYP_NEMVEDRAFT_V1G242153.2.4 m.15572 sp Y531_METJA 34.965 143 87 5 6 145 27 166 1.28E-12 64.7 Y531_METJA reviewed Universal stress protein MJ0531 (USP MJ0531) MJ0531 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 170 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q5R8Z6 CHOYP_DPSE_GA30097.1.1 m.24050 sp MCFD2_PONAB 47.619 126 53 2 115 240 32 144 1.28E-32 119 MCFD2_PONAB reviewed Multiple coagulation factor deficiency protein 2 homolog MCFD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 146 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005509; GO:0005783; GO:0005793; GO:0005794; GO:0015031; GO:0016192 0 0 0 PF13499; Q5U2Z0 CHOYP_LOC100727208.1.1 m.9365 sp ZN367_RAT 55.932 177 74 1 13 189 104 276 1.28E-57 194 ZN367_RAT reviewed Zinc finger protein 367 Znf367 Zfp367 Rattus norvegicus (Rat) 340 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005654; GO:0006351; GO:0006357; GO:0046872 0 0 0 PF13912; Q5ZIJ9 CHOYP_LOC100374277.2.3 m.23204 sp MIB2_CHICK 35.564 807 461 10 2 776 12 791 1.28E-168 523 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q66J85 CHOYP_LOC100636813.1.1 m.19517 sp ZFAN3_XENLA 35.102 245 109 6 21 254 16 221 1.28E-33 124 ZFAN3_XENLA reviewed AN1-type zinc finger protein 3 homolog zfand3 Xenopus laevis (African clawed frog) 226 0 GO:0003677; GO:0008270 0 0 0 PF01754;PF01428; Q68Y56 CHOYP_BRAFLDRAFT_68489.2.3 m.31420 sp TLR4_PIG 28.53 347 212 12 8 351 462 775 1.28E-28 121 TLR4_PIG reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Sus scrofa (Pig) 841 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0001530; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005887; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13855;PF01582; Q801G2 CHOYP_LOC100369738.1.1 m.54233 sp MPRAB_DANRE 34.058 276 177 2 13 284 36 310 1.28E-55 187 MPRAB_DANRE reviewed "Membrane progestin receptor alpha-B (mPR alpha) (Progestin and adipoQ receptor family member VII, b)" paqr7b mpra paqr7 Danio rerio (Zebrafish) (Brachydanio rerio) 354 activation of MAPK activity [GO:0000187]; multicellular organism development [GO:0007275]; negative regulation of adenylate cyclase activity [GO:0007194]; oocyte maturation [GO:0001556]; response to steroid hormone [GO:0048545]; signal transduction [GO:0007165] GO:0000187; GO:0001556; GO:0003707; GO:0005496; GO:0005886; GO:0007165; GO:0007194; GO:0007275; GO:0016021; GO:0048545 0 0 0 PF03006; Q86UB2 CHOYP_BIVM.1.3 m.22809 sp BIVM_HUMAN 71 100 29 0 230 329 190 289 1.28E-47 170 BIVM_HUMAN reviewed Basic immunoglobulin-like variable motif-containing protein BIVM Homo sapiens (Human) 503 0 GO:0005615; GO:0005634; GO:0005737 0 0 0 0 Q8BH75 CHOYP_LOC100375062.1.1 m.1662 sp RNF41_MOUSE 35.533 197 91 3 1 186 1 172 1.28E-30 119 RNF41_MOUSE reviewed E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-) (RING finger protein 41) Rnf41 Flrf Nrdp1 Mus musculus (Mouse) 317 autophagy [GO:0006914]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of macromitophagy [GO:1901525]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of protein kinase B signaling [GO:0051896]; regulation of reactive oxygen species metabolic process [GO:2000377] GO:0000209; GO:0004842; GO:0005128; GO:0005135; GO:0006914; GO:0008270; GO:0008285; GO:0010468; GO:0010498; GO:0016567; GO:0016881; GO:0017160; GO:0030336; GO:0031386; GO:0043408; GO:0045619; GO:0045637; GO:0051091; GO:0051865; GO:0051896; GO:0061630; GO:0097191; GO:1901525; GO:2000114; GO:2000377; GO:2000379 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF08941; Q8C6L5 CHOYP_NEMVEDRAFT_V1G199927.6.9 m.51528 sp CGAS_MOUSE 28.105 153 96 3 2 140 328 480 1.28E-09 63.5 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8IVG5 CHOYP_LOC100368251.1.6 m.23533 sp SAM9L_HUMAN 22.565 421 276 18 32 430 1190 1582 1.28E-12 74.3 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8K0H5 CHOYP_ZN407.1.1 m.59121 sp TAF10_MOUSE 71.901 121 28 3 21 138 100 217 1.28E-55 176 TAF10_MOUSE reviewed Transcription initiation factor TFIID subunit 10 (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30) (mTAFII30) Taf10 Taf2h Tafii30 Mus musculus (Mouse) 218 "apoptotic process [GO:0006915]; cellular protein complex assembly [GO:0043623]; DNA-templated transcription, initiation [GO:0006352]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte differentiation [GO:0070365]; histone deubiquitination [GO:0016578]; histone H3 acetylation [GO:0043966]; liver development [GO:0001889]; multicellular organism growth [GO:0035264]; protein homooligomerization [GO:0051260]; regulation of DNA binding [GO:0051101]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000082; GO:0000125; GO:0001889; GO:0003677; GO:0003713; GO:0005634; GO:0005669; GO:0005737; GO:0006352; GO:0006355; GO:0006367; GO:0006915; GO:0010468; GO:0016578; GO:0019899; GO:0030331; GO:0030914; GO:0033276; GO:0035264; GO:0043623; GO:0043966; GO:0048471; GO:0051101; GO:0051260; GO:0070063; GO:0070365 0 0 cd07982; PF03540; Q8KWM1 CHOYP_NEMVEDRAFT_V1G229510.1.4 m.28805 sp SDRI_STASA 37.356 174 109 0 246 419 93 266 1.28E-09 65.5 SDRI_STASA reviewed Serine-aspartate repeat-containing protein I sdrI Staphylococcus saprophyticus 1893 cell adhesion [GO:0007155] GO:0005576; GO:0005618; GO:0007155; GO:0016020 0 0 0 PF00746;PF10425;PF04650; Q8ND61 CHOYP_BRAFLDRAFT_118221.1.2 m.29049 sp CC020_HUMAN 33.333 171 108 4 822 990 666 832 1.28E-24 114 CC020_HUMAN reviewed Uncharacterized protein C3orf20 C3orf20 Homo sapiens (Human) 904 0 GO:0005737; GO:0016021 0 0 0 PF14977; Q91YD4 CHOYP_TRPM1.3.4 m.57631 sp TRPM2_MOUSE 25.637 628 371 21 407 976 486 1075 1.28E-38 160 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q99020 CHOYP_ROAA.3.6 m.39522 sp ROAA_MOUSE 53.672 177 81 1 48 224 59 234 1.28E-55 186 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q99LW6 CHOYP_YAF2.1.1 m.9592 sp YAF2_MOUSE 41.86 172 57 4 1 170 1 131 1.28E-31 116 YAF2_MOUSE reviewed YY1-associated factor 2 Yaf2 Mus musculus (Mouse) 179 "negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0008270; GO:0045892; GO:0045893 0 0 0 PF00641; Q9CPW4 CHOYP_FYN.1.1 m.44312 sp ARPC5_MOUSE 52.98 151 70 1 1 150 1 151 1.28E-50 161 ARPC5_MOUSE reviewed Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) Arpc5 Mus musculus (Mouse) 151 Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell migration [GO:0016477] GO:0005200; GO:0005737; GO:0005885; GO:0005925; GO:0016477; GO:0030027; GO:0034314; GO:0070062 0 0 0 PF04699; Q9CPW4 CHOYP_LOC100376381.1.1 m.10783 sp ARPC5_MOUSE 52.98 151 70 1 1 150 1 151 1.28E-50 161 ARPC5_MOUSE reviewed Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC) Arpc5 Mus musculus (Mouse) 151 Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell migration [GO:0016477] GO:0005200; GO:0005737; GO:0005885; GO:0005925; GO:0016477; GO:0030027; GO:0034314; GO:0070062 0 0 0 PF04699; Q9CY94 CHOYP_GINS3.1.1 m.18574 sp PSF3_MOUSE 53.266 199 88 2 7 200 18 216 1.28E-75 229 PSF3_MOUSE reviewed DNA replication complex GINS protein PSF3 (GINS complex subunit 3) Gins3 Psf3 Mus musculus (Mouse) 216 DNA replication [GO:0006260] GO:0005654; GO:0006260 0 0 0 PF05916; Q9FPH0 CHOYP_TC00.1047053509805.80.1.1 m.52007 sp XB34_ARATH 37.037 54 34 0 294 347 321 374 1.28E-07 56.2 XB34_ARATH reviewed Putative E3 ubiquitin-protein ligase XBAT34 (EC 6.3.2.-) (Ankyrin repeat domain and RING finger-containing protein XBAT34) (Protein XB3 homolog 4) XBAT34 At4g14365 dl3220c FCAALL.222 Arabidopsis thaliana (Mouse-ear cress) 376 protein ubiquitination [GO:0016567] GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q9H841 CHOYP_LOC100204708.1.1 m.36399 sp NPAL2_HUMAN 44.295 298 166 0 12 309 33 330 1.28E-78 250 NPAL2_HUMAN reviewed NIPA-like protein 2 NIPAL2 NPAL2 Homo sapiens (Human) 368 magnesium ion transport [GO:0015693] GO:0015095; GO:0015693; GO:0016021 0 0 0 PF05653; Q9JI18 CHOYP_LOC578656.9.15 m.53454 sp LRP1B_MOUSE 25.689 907 577 37 113 975 1329 2182 1.28E-56 220 LRP1B_MOUSE reviewed Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) 4599 in utero embryonic development [GO:0001701] GO:0001701; GO:0005041; GO:0005509; GO:0016020; GO:0016021; GO:0043235; GO:0050750 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q9JLC8 CHOYP_SACS.8.17 m.43756 sp SACS_MOUSE 52.941 51 23 1 105 155 90 139 1.28E-07 53.1 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9N003 CHOYP_BRAFLDRAFT_57344.1.1 m.25090 sp ZN425_MACFA 32.136 529 303 9 416 944 265 737 1.28E-75 270 ZN425_MACFA reviewed Zinc finger protein 425 (Fragment) ZNF425 QccE-16628 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 741 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005737; GO:0006351; GO:0045892; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q9NL82 CHOYP_LOC101067281.2.2 m.62001 sp ORCKB_PROCL 39.726 292 132 22 8 293 5 258 1.28E-24 104 ORCKB_PROCL reviewed Orcokinin peptides type B [Cleaved into: Orcomyotropin-like peptide; Orcokinin-like peptide 1; Orcokinin; Orcokinin-like peptide 2; Orcokinin-like peptide 3; Orcokinin-like peptide 4] 0 Procambarus clarkii (Red swamp crayfish) 266 neuropeptide signaling pathway [GO:0007218] GO:0005184; GO:0005576; GO:0007218 0 0 0 0 Q9NUV9 CHOYP_LOC101164984.1.2 m.22324 sp GIMA4_HUMAN 39.86 286 167 3 116 401 28 308 1.28E-63 210 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9ULI1 CHOYP_LOC100679890.1.1 m.57122 sp NWD2_HUMAN 21.597 1102 751 33 1 1031 365 1424 1.28E-48 194 NWD2_HUMAN reviewed NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 0 0 0 0 0 PF13271; Q9VCA2 CHOYP_LOC100878786.1.1 m.55152 sp ORCT_DROME 35.502 538 321 7 1 526 1 524 1.28E-112 348 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; A4IF63 CHOYP_BRAFLDRAFT_87302.2.3 m.63639 sp TRIM2_BOVIN 25.342 146 104 3 232 375 602 744 1.29E-06 55.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7MBP4 CHOYP_LOC590756.2.6 m.28778 sp IFT46_DANRE 65.476 252 76 2 76 327 143 383 1.29E-111 332 IFT46_DANRE reviewed Intraflagellar transport protein 46 homolog ift46 Danio rerio (Zebrafish) (Brachydanio rerio) 384 cilium assembly [GO:0042384]; determination of ventral identity [GO:0048264]; intraciliary transport [GO:0042073]; pronephros development [GO:0048793]; retina development in camera-type eye [GO:0060041] GO:0005737; GO:0005813; GO:0030992; GO:0036064; GO:0042073; GO:0042384; GO:0048264; GO:0048793; GO:0060041 0 0 0 PF12317; B1WB06 CHOYP_LOC100373794.4.5 m.62089 sp MET24_XENTR 31.034 174 106 5 304 465 117 288 1.29E-14 78.6 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; B5X4E0 CHOYP_CALUB.1.2 m.57842 sp CALUB_SALSA 54.574 317 121 8 7 320 1 297 1.29E-102 306 CALUB_SALSA reviewed Calumenin-B calub Salmo salar (Atlantic salmon) 316 0 GO:0005509; GO:0005576; GO:0005789; GO:0005794; GO:0033018; GO:0042470 0 0 0 PF13202;PF13833; C4YDI6 CHOYP_LOC100704818.1.1 m.30237 sp CDC42_CANAW 35.294 187 108 4 31 205 2 187 1.29E-30 114 CDC42_CANAW reviewed Cell division control protein 42 homolog CDC42 CAWG_00581 Candida albicans (strain WO-1) (Yeast) 191 cell cycle [GO:0007049]; cell division [GO:0051301]; pathogenesis [GO:0009405]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007049; GO:0007264; GO:0009405; GO:0051301 0 0 0 PF00071; D2GXS7 CHOYP_BRAFLDRAFT_69765.4.23 m.27896 sp TRIM2_AILME 33.019 106 66 4 6 107 627 731 1.29E-07 52 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O08795 CHOYP_LOC763794.1.1 m.14815 sp GLU2B_MOUSE 37.195 164 76 4 76 235 16 156 1.29E-25 110 GLU2B_MOUSE reviewed Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) Prkcsh Mus musculus (Mouse) 521 in utero embryonic development [GO:0001701]; liver development [GO:0001889]; negative regulation of neuron projection development [GO:0010977]; N-glycan processing [GO:0006491]; nitrogen compound metabolic process [GO:0006807]; protein heterooligomerization [GO:0051291]; renal system development [GO:0072001] GO:0001701; GO:0001889; GO:0003723; GO:0005080; GO:0005509; GO:0005783; GO:0006491; GO:0006807; GO:0010977; GO:0044325; GO:0051219; GO:0051291; GO:0072001 PATHWAY: Glycan metabolism; N-glycan metabolism. 0 0 PF13202;PF12999;PF13015; O08863 CHOYP_LOC101242540.1.2 m.6465 sp BIRC3_MOUSE 41.25 80 46 1 279 358 522 600 1.29E-11 69.3 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; O55060 CHOYP_LOC101064328.3.3 m.61539 sp TPMT_MOUSE 34.091 220 139 5 41 254 19 238 1.29E-33 124 TPMT_MOUSE reviewed Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) Tpmt Mus musculus (Mouse) 240 nucleobase-containing compound metabolic process [GO:0006139] GO:0005737; GO:0006139; GO:0008119; GO:0070062 0 0 0 PF05724; O73853 CHOYP_LOC100371830.5.6 m.55811 sp CP17A_ICTPU 33.264 478 303 7 31 499 31 501 1.29E-91 291 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; O75095 CHOYP_MEGF6.26.59 m.36487 sp MEGF6_HUMAN 33.226 623 377 15 29 635 43 642 1.29E-75 267 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75179 CHOYP_LOC581927.12.27 m.35500 sp ANR17_HUMAN 35.821 469 283 14 8 460 222 688 1.29E-64 229 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75420 CHOYP_PERQ2.2.2 m.40796 sp PERQ1_HUMAN 41.875 320 128 10 27 294 3 316 1.29E-41 170 PERQ1_HUMAN reviewed PERQ amino acid-rich with GYF domain-containing protein 1 (GRB10-interacting GYF protein 1) GIGYF1 CDS2 PERQ1 PP3360 Homo sapiens (Human) 1035 insulin-like growth factor receptor signaling pathway [GO:0048009] GO:0048009 0 0 0 PF02213; O75808 CHOYP_SOLH.1.2 m.2794 sp CAN15_HUMAN 25.352 142 84 6 93 223 416 546 1.29E-06 52 CAN15_HUMAN reviewed Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) CAPN15 SOLH Homo sapiens (Human) 1086 0 GO:0003700; GO:0004198; GO:0005737; GO:0008233; GO:0008234; GO:0008270 0 0 0 PF00648;PF00641; O80434 CHOYP_LOC100206475.6.16 m.36736 sp LAC4_ARATH 28.356 596 300 17 99 662 44 544 1.29E-48 182 LAC4_ARATH reviewed Laccase-4 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 4) (Diphenol oxidase 4) (Protein IRREGULAR XYLEM 12) (Urishiol oxidase 4) IRX12 LAC4 At2g38080 F16M14.1 Arabidopsis thaliana (Mouse-ear cress) 558 lignin biosynthetic process [GO:0009809]; lignin catabolic process [GO:0046274]; plant-type secondary cell wall biogenesis [GO:0009834] GO:0005507; GO:0009809; GO:0009834; GO:0016491; GO:0016722; GO:0046274; GO:0048046; GO:0052716 0 0 0 PF00394;PF07731;PF07732; O94868 CHOYP_BRAFLDRAFT_82966.1.1 m.44493 sp FCSD2_HUMAN 39.075 389 220 6 1 386 1 375 1.29E-79 265 FCSD2_HUMAN reviewed F-BAR and double SH3 domains protein 2 (Carom) (SH3 multiple domains protein 3) FCHSD2 KIAA0769 SH3MD3 Homo sapiens (Human) 740 0 0 0 0 0 PF00611;PF00018;PF14604; O95236 CHOYP_contig_044840 m.52008 sp APOL3_HUMAN 23.305 236 144 5 470 681 160 382 1.29E-06 55.1 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P06734 CHOYP_SI_DKEYP-75B4.10.2.2 m.54469 sp FCER2_HUMAN 35.088 114 63 5 46 158 174 277 1.29E-10 65.9 FCER2_HUMAN reviewed Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] FCER2 CD23A CLEC4J FCE2 IGEBF Homo sapiens (Human) 321 Notch signaling pathway [GO:0007219]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0005178; GO:0005886; GO:0005887; GO:0007219; GO:0009897; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P10079 CHOYP_LOC582329.2.2 m.38647 sp FBP1_STRPU 61.635 159 61 0 2 160 398 556 1.29E-56 194 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11414 CHOYP_CLUG_04850.1.4 m.17283 sp RPB1_CRIGR 36.538 104 63 1 331 431 353 456 1.29E-07 57.4 RPB1_CRIGR reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (Fragment) POLR2A Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 467 positive regulation of RNA splicing [GO:0033120]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0005665; GO:0006366; GO:0033120 0 0 0 PF05001; P16157 CHOYP_TVAG_020440.19.21 m.54163 sp ANK1_HUMAN 36.73 471 294 1 7 477 32 498 1.29E-88 300 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18433 CHOYP_PTPRM.15.15 m.61936 sp PTPRA_HUMAN 31.14 684 416 18 733 1391 141 794 1.29E-88 310 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P20241 CHOYP_PHUM_PHUM477110.1.1 m.53813 sp NRG_DROME 26.998 463 285 22 24 458 26 463 1.29E-28 126 NRG_DROME reviewed Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) 1302 "axon ensheathment [GO:0008366]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell adhesion involved in heart morphogenesis [GO:0061343]; central complex development [GO:0048036]; dendrite morphogenesis [GO:0048813]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of glial blood-brain barrier [GO:0060857]; female courtship behavior [GO:0008050]; imaginal disc morphogenesis [GO:0007560]; male courtship behavior [GO:0008049]; melanotic encapsulation of foreign target [GO:0035011]; motor neuron axon guidance [GO:0008045]; mushroom body development [GO:0016319]; nerve maturation [GO:0021682]; neuron cell-cell adhesion [GO:0007158]; neuron projection morphogenesis [GO:0048812]; photoreceptor cell axon guidance [GO:0072499]; regulation of female receptivity [GO:0045924]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; synapse organization [GO:0050808]" GO:0005509; GO:0005886; GO:0005918; GO:0005919; GO:0005923; GO:0007158; GO:0007173; GO:0007409; GO:0007560; GO:0008045; GO:0008049; GO:0008050; GO:0008366; GO:0016021; GO:0016319; GO:0016328; GO:0019991; GO:0021682; GO:0030175; GO:0035011; GO:0035151; GO:0045924; GO:0048036; GO:0048675; GO:0048812; GO:0048813; GO:0050808; GO:0060857; GO:0061343; GO:0072499 0 0 0 PF13882;PF00041;PF07679;PF00047; P28828 CHOYP_PTPRT.26.45 m.52045 sp PTPRM_MOUSE 39.123 570 334 8 844 1403 884 1450 1.29E-121 417 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P35408 CHOYP_LOC100705061.1.2 m.23577 sp PE2R4_HUMAN 31.325 332 183 5 25 313 22 351 1.29E-40 152 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P38552 CHOYP_TBB.5.7 m.60062 sp LEG4_RAT 39.803 304 156 8 10 296 14 307 1.29E-60 199 LEG4_RAT reviewed Galectin-4 (Gal-4) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) Lgals4 Rattus norvegicus (Rat) 324 0 GO:0005615; GO:0016936; GO:0030246 0 0 0 PF00337; P39447 CHOYP_ISCW_ISCW019818.1.1 m.12276 sp ZO1_MOUSE 57.895 95 40 0 34 128 15 109 1.29E-30 122 ZO1_MOUSE reviewed Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) Tjp1 Zo1 Mus musculus (Mouse) 1745 blastocyst formation [GO:0001825]; establishment of endothelial intestinal barrier [GO:0090557]; sensory perception of sound [GO:0007605] GO:0001825; GO:0005634; GO:0005737; GO:0005886; GO:0005911; GO:0005912; GO:0005913; GO:0005921; GO:0005923; GO:0007605; GO:0009986; GO:0014704; GO:0016020; GO:0016323; GO:0016324; GO:0016327; GO:0019904; GO:0030054; GO:0031674; GO:0043296; GO:0045177; GO:0046581; GO:0090557 0 0 0 PF00625;PF00595;PF07653;PF00791; P48725 CHOYP_LOC100368547.17.40 m.20514 sp PCNT_MOUSE 36.09 133 80 3 1 131 2739 2868 1.29E-12 70.1 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; P49395 CHOYP_RS3A.14.15 m.57763 sp RS3A_APLCA 81.509 265 46 1 22 283 1 265 1.29E-153 432 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P49747 CHOYP_TSP1.1.1 m.43966 sp COMP_HUMAN 53.266 398 177 7 476 869 68 460 1.29E-110 363 COMP_HUMAN reviewed Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5) COMP Homo sapiens (Human) 757 apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; growth plate cartilage development [GO:0003417]; limb development [GO:0060173]; negative regulation of apoptotic process [GO:0043066]; organ morphogenesis [GO:0009887]; skeletal system development [GO:0001501] GO:0001501; GO:0002020; GO:0003417; GO:0005201; GO:0005509; GO:0005518; GO:0005576; GO:0005578; GO:0005615; GO:0006915; GO:0007155; GO:0008201; GO:0009887; GO:0030198; GO:0043066; GO:0043395; GO:0060173; GO:0070062 0 0 0 PF11598;PF07645;PF02412;PF05735; P83871 CHOYP_PHF5A.1.1 m.32389 sp PHF5A_RAT 96.364 110 4 0 12 121 1 110 1.29E-73 217 PHF5A_RAT reviewed PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b) Phf5a Ini Rattus norvegicus (Rat) 110 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000398; GO:0003677; GO:0003700; GO:0005686; GO:0005689; GO:0006351; GO:0016363; GO:0016607; GO:0044822; GO:0045893; GO:0071011; GO:0071013 0 0 0 PF03660; P86221 CHOYP_LOC373275.1.7 m.4771 sp TBB4B_MESAU 97.987 149 3 0 22 170 1 149 1.29E-107 312 TBB4B_MESAU reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) 290 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091; P87132 CHOYP_NEMVEDRAFT_V1G236658.4.6 m.30181 sp YFK5_SCHPO 31.293 147 91 3 6 149 432 571 1.29E-08 56.2 YFK5_SCHPO reviewed Uncharacterized protein C167.05 SPAC167.05 SPAC57A7.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 601 response to stress [GO:0006950] GO:0005829; GO:0006950 0 0 0 PF00582; P96202 CHOYP_LOC100373061.1.2 m.41170 sp PPSC_MYCTU 27.047 403 260 13 734 1121 1763 2146 1.29E-29 133 PPSC_MYCTU reviewed Phthiocerol synthesis polyketide synthase type I PpsC (Beta-ketoacyl-acyl-carrier-protein synthase I) (EC 2.3.1.41) ppsC Rv2933 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 2188 Actinobacterium-type cell wall biogenesis [GO:0071766]; DIM/DIP cell wall layer assembly [GO:0071770]; fatty acid biosynthetic process [GO:0006633]; phenolic phthiocerol biosynthetic process [GO:0097041]; phthiocerol biosynthetic process [GO:0097040] GO:0004315; GO:0005829; GO:0005886; GO:0006633; GO:0016491; GO:0031177; GO:0034081; GO:0071766; GO:0071770; GO:0097040; GO:0097041 PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 PF00698;PF08240;PF16197;PF00109;PF02801;PF08659;PF00550;PF14765; Q03601 CHOYP_BRAFLDRAFT_102380.8.11 m.55814 sp NHL1_CAEEL 31.538 130 58 5 7 115 41 160 1.29E-09 64.7 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q03692 CHOYP_LOC101167364.1.1 m.22267 sp COAA1_HUMAN 30.986 142 84 4 38 179 553 680 1.29E-07 53.9 COAA1_HUMAN reviewed Collagen alpha-1(X) chain COL10A1 Homo sapiens (Human) 680 cartilage development [GO:0051216]; collagen catabolic process [GO:0030574]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501] GO:0001501; GO:0001958; GO:0005576; GO:0005578; GO:0005581; GO:0005788; GO:0005938; GO:0030198; GO:0030574; GO:0046872; GO:0051216 0 0 0 PF00386;PF01391; Q05209 CHOYP_PHUM_PHUM574190.1.1 m.24768 sp PTN12_HUMAN 40.924 303 174 3 10 312 5 302 1.29E-78 273 PTN12_HUMAN reviewed Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) PTPN12 Homo sapiens (Human) 780 cellular response to epidermal growth factor stimulus [GO:0071364]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; tissue regeneration [GO:0042246] GO:0002102; GO:0004721; GO:0004726; GO:0005737; GO:0005829; GO:0005886; GO:0005925; GO:0006470; GO:0017124; GO:0035335; GO:0042058; GO:0042246; GO:0042995; GO:0071364 0 0 0 PF00102; Q06234 CHOYP_ASCL1.1.2 m.11562 sp ASCL1_XENLA 54.194 155 60 4 53 205 54 199 1.29E-34 124 ASCL1_XENLA reviewed Achaete-scute homolog 1 ascl1 ash1 Xenopus laevis (African clawed frog) 199 "positive regulation of neuron differentiation [GO:0045666]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron fate commitment [GO:0060579]" GO:0000989; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0045666; GO:0060579 0 0 0 PF00010; Q06831 CHOYP_ISCW_ISCW015396.1.1 m.41839 sp SOX4_MOUSE 76.136 88 21 0 24 111 48 135 1.29E-41 153 SOX4_MOUSE reviewed Transcription factor SOX-4 Sox4 Sox-4 Mus musculus (Mouse) 440 "ascending aorta morphogenesis [GO:0035910]; atrial septum primum morphogenesis [GO:0003289]; canonical Wnt signaling pathway [GO:0060070]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac ventricle formation [GO:0003211]; cellular response to glucose stimulus [GO:0071333]; DNA damage response, detection of DNA damage [GO:0042769]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endocrine pancreas development [GO:0031018]; glial cell development [GO:0021782]; glial cell proliferation [GO:0014009]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; kidney morphogenesis [GO:0060993]; limb bud formation [GO:0060174]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell death [GO:0060548]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of protein ubiquitination [GO:0031397]; neural tube formation [GO:0001841]; neuroepithelial cell differentiation [GO:0060563]; noradrenergic neuron differentiation [GO:0003357]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell proliferation [GO:0008284]; positive regulation of insulin secretion [GO:0032024]; positive regulation of N-terminal peptidyl-lysine acetylation [GO:2000761]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of translation [GO:0045727]; positive regulation of Wnt signaling pathway [GO:0030177]; pro-B cell differentiation [GO:0002328]; protein stabilization [GO:0050821]; regulation of protein stability [GO:0031647]; regulation of transcription, DNA-templated [GO:0006355]; skeletal system development [GO:0001501]; somatic stem cell population maintenance [GO:0035019]; spinal cord development [GO:0021510]; spinal cord motor neuron differentiation [GO:0021522]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; ventricular septum morphogenesis [GO:0060412]" GO:0000976; GO:0000981; GO:0001046; GO:0001071; GO:0001077; GO:0001105; GO:0001501; GO:0001841; GO:0002328; GO:0003183; GO:0003211; GO:0003215; GO:0003289; GO:0003357; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0006355; GO:0006977; GO:0007507; GO:0008284; GO:0008285; GO:0014009; GO:0021510; GO:0021522; GO:0021782; GO:0030177; GO:0030217; GO:0031018; GO:0031397; GO:0031647; GO:0032024; GO:0035019; GO:0035910; GO:0042593; GO:0042769; GO:0043065; GO:0044798; GO:0045727; GO:0045893; GO:0045944; GO:0046826; GO:0046982; GO:0048485; GO:0050821; GO:0060070; GO:0060174; GO:0060412; GO:0060548; GO:0060563; GO:0060993; GO:0071333; GO:0090263; GO:2000761 0 0 0 PF00505; Q0IIB1 CHOYP_PHYD1.1.2 m.17822 sp PHYD1_BOVIN 54.795 292 122 5 2 287 3 290 1.29E-108 319 PHYD1_BOVIN reviewed Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC 1.-.-.-) PHYHD1 Bos taurus (Bovine) 291 0 GO:0046872; GO:0051213 0 0 0 PF05721; Q27928 CHOYP_AAEL_AAEL001593.1.1 m.34616 sp GPDA_DROPS 74.138 116 30 0 1 116 235 350 1.29E-60 192 GPDA_DROPS reviewed "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)" Gpdh Drosophila pseudoobscura pseudoobscura (Fruit fly) 360 carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerophospholipid metabolic process [GO:0006650] GO:0004367; GO:0005975; GO:0006650; GO:0009331; GO:0046168; GO:0051287 PATHWAY: Phospholipid metabolism; alpha-glycerophosphate cycle. 0 0 PF07479;PF01210; Q3U0L2 CHOYP_LOC659710.1.1 m.7101 sp AN33B_MOUSE 44.025 159 89 0 24 182 84 242 1.29E-33 130 AN33B_MOUSE reviewed Ankyrin repeat domain-containing protein 33B Ankrd33b Mus musculus (Mouse) 486 0 GO:0003677 0 0 0 PF12796; Q3U3N6 CHOYP_AP4AT.1.1 m.62409 sp AP4AT_MOUSE 33.89 419 244 8 7 397 3 416 1.29E-55 195 AP4AT_MOUSE reviewed AP-4 complex accessory subunit tepsin (ENTH domain-containing protein 2) (Tetra-epsin) Enthd2 Mus musculus (Mouse) 573 0 GO:0005829; GO:0016023 0 0 0 PF01417; Q4KLI9 CHOYP_ISCW_ISCW008293.5.5 m.58344 sp FBXW5_RAT 25 288 189 10 6 284 2 271 1.29E-12 73.6 FBXW5_RAT reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) 569 centrosome duplication [GO:0051298]; mitotic nuclear division [GO:0007067]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000151; GO:0005737; GO:0007067; GO:0010824; GO:0016567; GO:0019005; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q4ZJM9 CHOYP_C1QL4L.7.7 m.36358 sp C1QL4_MOUSE 34.146 123 67 5 156 276 125 235 1.29E-06 52 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q555N7 CHOYP_LOC101164114.1.1 m.1539 sp ZDHC4_DICDI 39.423 104 62 1 170 273 125 227 1.29E-16 83.6 ZDHC4_DICDI reviewed Putative ZDHHC-type palmitoyltransferase 4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) DDB_G0274251 Dictyostelium discoideum (Slime mold) 358 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q55E58 CHOYP_LOC100888832.1.1 m.35201 sp PATS1_DICDI 26.667 375 216 14 74 443 1695 2015 1.29E-19 97.1 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q57951 CHOYP_NEMVEDRAFT_V1G236573.2.2 m.47233 sp Y531_METJA 29.801 151 86 6 7 150 29 166 1.29E-07 51.6 Y531_METJA reviewed Universal stress protein MJ0531 (USP MJ0531) MJ0531 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 170 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q59GN2 CHOYP_BRAFLDRAFT_57258.1.3 m.43523 sp R39L5_HUMAN 87.5 24 3 0 3 26 13 36 1.29E-08 50.1 R39L5_HUMAN reviewed Putative 60S ribosomal protein L39-like 5 (60S ribosomal protein L39 pseudogene 5) RPL39P5 Homo sapiens (Human) 51 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00832; Q5E9T8 CHOYP_BRAFLDRAFT_219207.1.1 m.13793 sp KIME_BOVIN 41.451 386 218 3 7 392 2 379 1.29E-87 273 KIME_BOVIN reviewed Mevalonate kinase (MK) (EC 2.7.1.36) MVK Bos taurus (Bovine) 396 "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]" GO:0004496; GO:0005524; GO:0005777; GO:0006695; GO:0019287 PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. 0 0 PF08544;PF00288; Q5GH73 CHOYP_BRAFLDRAFT_255437.1.1 m.66499 sp XKR6_HUMAN 36.508 63 40 0 94 156 126 188 1.29E-06 52 XKR6_HUMAN reviewed XK-related protein 6 XKR6 C8orf21 C8orf5 C8orf7 XRG6 Homo sapiens (Human) 641 0 GO:0016020; GO:0016021 0 0 0 PF09815; Q5U243 CHOYP_BRAFLDRAFT_88570.2.2 m.57539 sp CLIP3_XENLA 38.462 91 41 2 1485 1575 275 350 1.29E-07 60.1 CLIP3_XENLA reviewed CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) clip3 clipr59 Xenopus laevis (African clawed frog) 534 0 GO:0005795; GO:0005802; GO:0005886; GO:0010008; GO:0045121 0 0 0 PF12796;PF01302; Q5UPH0 CHOYP_LOC753709.40.44 m.64120 sp YL100_MIMIV 42 100 52 3 10 107 317 412 1.29E-15 74.3 YL100_MIMIV reviewed Putative ankyrin repeat protein L100 MIMI_L100 Acanthamoeba polyphaga mimivirus (APMV) 602 0 0 0 0 0 PF12796; Q5VWZ2 CHOYP_LOC100558843.1.1 m.14396 sp LYPL1_HUMAN 50.87 230 110 2 2 230 3 230 1.29E-77 236 LYPL1_HUMAN reviewed Lysophospholipase-like protein 1 (EC 3.1.2.-) LYPLAL1 Homo sapiens (Human) 237 protein depalmitoylation [GO:0002084] GO:0002084; GO:0004622; GO:0005737; GO:0005829; GO:0008474; GO:0052689; GO:0070062 0 0 0 PF02230; Q5ZJL9 CHOYP_SAMH1.5.12 m.31382 sp SAMH1_CHICK 42.359 373 187 6 2 355 87 450 1.29E-88 291 SAMH1_CHICK reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) 614 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966; Q5ZLF0 CHOYP_F10A1.2.4 m.11805 sp F10A1_CHICK 52.261 398 141 5 11 404 9 361 1.29E-128 378 F10A1_CHICK reviewed Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) ST13 FAM10A1 RCJMB04_6h13 Gallus gallus (Chicken) 361 0 GO:0005737 0 0 0 PF13181; Q68FA2 CHOYP_DANA_GF10165.1.1 m.59230 sp CT027_XENTR 36 150 88 6 16 162 29 173 1.29E-22 91.3 CT027_XENTR reviewed UPF0687 protein C20orf27 homolog 0 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 174 0 0 0 0 0 PF15006; Q6AYN9 CHOYP_BRAFLDRAFT_132233.4.4 m.54646 sp CC181_RAT 26.972 393 214 12 259 609 143 504 1.29E-18 92.8 CC181_RAT reviewed Coiled-coil domain-containing protein 181 Ccdc181 Rattus norvegicus (Rat) 509 0 GO:0005654 0 0 0 0 Q6DIB5 CHOYP_MEGF6.47.59 m.51005 sp MEG10_MOUSE 35.966 709 401 32 11 706 182 850 1.29E-88 305 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6JEL2 CHOYP_KLHL10.1.2 m.50311 sp KLH10_HUMAN 55.86 401 177 0 2 402 185 585 1.29E-167 486 KLH10_HUMAN reviewed Kelch-like protein 10 KLHL10 Homo sapiens (Human) 608 cell morphogenesis [GO:0000902]; fertilization [GO:0009566]; homeostasis of number of cells within a tissue [GO:0048873]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]; spermatid development [GO:0007286] GO:0000902; GO:0005737; GO:0007286; GO:0008584; GO:0009566; GO:0016567; GO:0031463; GO:0048808; GO:0048873 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6P6S2 CHOYP_NEMVEDRAFT_V1G167638.1.1 m.18413 sp S39AB_RAT 62.17 341 112 5 1 330 1 335 1.29E-141 406 S39AB_RAT reviewed Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11) Slc39a11 Zip11 Rattus norvegicus (Rat) 335 zinc II ion transmembrane transport [GO:0071577] GO:0005385; GO:0005634; GO:0005737; GO:0005794; GO:0005886; GO:0016020; GO:0016021; GO:0071577 0 0 0 PF02535; Q6ZPS2 CHOYP_CARNS1.3.6 m.15054 sp CRNS1_MOUSE 50.282 177 86 1 8 184 466 640 1.29E-47 171 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q7SXW4 CHOYP_BRAFLDRAFT_126946.1.1 m.64485 sp EMC3_DANRE 70 250 75 0 10 259 6 255 1.29E-131 375 EMC3_DANRE reviewed ER membrane protein complex subunit 3 (Protein pob) (Transmembrane protein 111) emc3 pob tmem111 zgc:63727 Danio rerio (Zebrafish) (Brachydanio rerio) 261 photoreceptor cell maintenance [GO:0045494]; protein folding in endoplasmic reticulum [GO:0034975]; retina development in camera-type eye [GO:0060041] GO:0005794; GO:0016021; GO:0030140; GO:0034975; GO:0045494; GO:0060041; GO:0072546 0 0 0 PF01956; Q7YRA3 CHOYP_LOC100368480.1.1 m.18235 sp EXOS4_BOVIN 66.387 238 80 0 1 238 1 238 1.29E-122 351 EXOS4_BOVIN reviewed Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) EXOSC4 RRP41 Bos taurus (Bovine) 245 "defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; rRNA 3'-end processing [GO:0031125]; rRNA catabolic process [GO:0016075]; U4 snRNA 3'-end processing [GO:0034475]" GO:0000176; GO:0000177; GO:0000178; GO:0000460; GO:0004527; GO:0005730; GO:0016075; GO:0017091; GO:0030307; GO:0031125; GO:0034427; GO:0034475; GO:0035327; GO:0045006; GO:0051607; GO:0071028; GO:0071044; GO:0071051 0 0 0 PF01138;PF03725; Q8IVH4 CHOYP_MMAA.1.1 m.9412 sp MMAA_HUMAN 55.416 397 163 4 37 423 22 414 1.29E-147 429 MMAA_HUMAN reviewed "Methylmalonic aciduria type A protein, mitochondrial (EC 3.6.-.-)" MMAA Homo sapiens (Human) 418 cobalamin biosynthetic process [GO:0009236]; cobalamin metabolic process [GO:0009235]; short-chain fatty acid catabolic process [GO:0019626] GO:0003924; GO:0005525; GO:0005759; GO:0009235; GO:0009236; GO:0019626 PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis. 0 0 0 Q8N1I0 CHOYP_DOCK3.1.2 m.49353 sp DOCK4_HUMAN 42.35 732 386 11 1035 1758 906 1609 1.29E-172 580 DOCK4_HUMAN reviewed Dedicator of cytokinesis protein 4 DOCK4 KIAA0716 Homo sapiens (Human) 1966 cell chemotaxis [GO:0060326]; negative regulation of vascular smooth muscle contraction [GO:1904694]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005096; GO:0005829; GO:0005886; GO:0007264; GO:0016020; GO:0030165; GO:0030971; GO:0032420; GO:0032421; GO:0048365; GO:0060326; GO:1904694; GO:1904754 0 0 0 PF06920;PF14429;PF16172;PF07653; Q8N3J6 CHOYP_BRAFLDRAFT_83800.1.1 m.51902 sp CADM2_HUMAN 25 240 161 9 105 343 91 312 1.29E-08 60.8 CADM2_HUMAN reviewed Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2) CADM2 IGSF4D NECL3 Homo sapiens (Human) 435 adherens junction organization [GO:0034332]; cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005886; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0030424; GO:0034332; GO:0042803; GO:0045202; GO:0050839 0 0 0 PF08205;PF07686; Q8NEZ4 CHOYP_contig_006033 m.6874 sp KMT2C_HUMAN 38.272 81 50 0 555 635 1638 1718 1.29E-10 69.7 KMT2C_HUMAN reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) 4911 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0008270; GO:0016746; GO:0018024; GO:0035097; GO:0042800; GO:0044666; GO:0044822 0 0 0 PF05965;PF05964;PF00628;PF00856; Q8TCB0 CHOYP_LOC100377780.11.11 m.57809 sp IFI44_HUMAN 26.773 437 274 13 21 446 22 423 1.29E-41 156 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q8TDW5 CHOYP_SYTL4.1.1 m.6162 sp SYTL5_HUMAN 45.536 448 202 8 1343 1754 286 727 1.29E-106 361 SYTL5_HUMAN reviewed Synaptotagmin-like protein 5 SYTL5 SLP5 Homo sapiens (Human) 730 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; intracellular protein transport [GO:0006886]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006886; GO:0006906; GO:0017158; GO:0019905; GO:0030276; GO:0048791; GO:0070382; GO:0098793 0 0 0 PF00168;PF02318; Q8WXE1 CHOYP_ATRIP.1.1 m.15992 sp ATRIP_HUMAN 31.214 173 102 3 162 329 95 255 1.29E-12 75.5 ATRIP_HUMAN reviewed ATR-interacting protein (ATM and Rad3-related-interacting protein) ATRIP AGS1 Homo sapiens (Human) 791 DNA damage checkpoint [GO:0000077]; DNA replication [GO:0006260]; interstrand cross-link repair [GO:0036297]; regulation of signal transduction by p53 class mediator [GO:1901796] GO:0000077; GO:0005654; GO:0006260; GO:0036297; GO:0070530; GO:1901796 0 0 0 0 Q91WM2 CHOYP_LOC100547770.1.1 m.48574 sp CECR5_MOUSE 45.263 95 51 1 39 132 45 139 1.29E-18 84.3 CECR5_MOUSE reviewed Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) 419 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q91ZI0 CHOYP_BRAFLDRAFT_133692.2.4 m.35324 sp CELR3_MOUSE 24.948 477 303 17 344 786 593 1048 1.29E-19 99 CELR3_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 3 Celsr3 Mus musculus (Mouse) 3301 axonal fasciculation [GO:0007413]; cilium assembly [GO:0042384]; dopaminergic neuron axon guidance [GO:0036514]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; planar cell polarity pathway involved in axon guidance [GO:1904938]; regulation of protein localization [GO:0032880]; regulation of protein phosphorylation [GO:0001932]; serotonergic neuron axon guidance [GO:0036515] GO:0001764; GO:0001932; GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007413; GO:0016021; GO:0032880; GO:0036514; GO:0036515; GO:0042384; GO:1904938 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q92982 CHOYP_DCA11.1.1 m.56743 sp NINJ1_HUMAN 27.632 76 55 0 41 116 39 114 1.29E-06 49.3 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q949P2 CHOYP_LOC660684.1.1 m.28592 sp COPDA_ARATH 25.591 719 465 23 40 717 2 691 1.29E-56 208 COPDA_ARATH reviewed Probable cytosolic oligopeptidase A (EC 3.4.24.70) (Thimet metalloendopeptidase 2) (Zincin-like metalloproteases family protein 2) CYOP TOP2 At5g10540 F12B17.110 Arabidopsis thaliana (Mouse-ear cress) 701 peptide metabolic process [GO:0006518]; response to cadmium ion [GO:0046686] GO:0004222; GO:0005829; GO:0006518; GO:0009507; GO:0046686; GO:0046872; GO:0048046 0 0 0 PF01432; Q96GP6 CHOYP_MEG10.6.91 m.17994 sp SREC2_HUMAN 38.947 190 101 7 200 385 236 414 1.29E-24 109 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_240123.3.6 m.26783 sp HS12B_HUMAN 30.22 182 119 5 16 193 56 233 1.29E-16 80.5 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96P65 CHOYP_BRAFLDRAFT_202783.1.2 m.21505 sp QRFPR_HUMAN 30.793 328 204 9 21 336 33 349 1.29E-42 156 QRFPR_HUMAN reviewed Pyroglutamylated RFamide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) QRFPR GPR103 Homo sapiens (Human) 431 cellular response to hormone stimulus [GO:0032870]; G-protein coupled receptor signaling pathway [GO:0007186]; response to peptide [GO:1901652] GO:0004930; GO:0004983; GO:0005886; GO:0005887; GO:0007186; GO:0016021; GO:0032870; GO:0042277; GO:1901652 0 0 0 PF00001; Q99JW2 CHOYP_BRAFLDRAFT_262219.2.2 m.65564 sp ACY1_MOUSE 57.035 398 168 2 2 399 8 402 1.29E-169 483 ACY1_MOUSE reviewed Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) Acy1 Mus musculus (Mouse) 408 cellular amino acid metabolic process [GO:0006520]; peptide catabolic process [GO:0043171] GO:0004046; GO:0005737; GO:0006520; GO:0008270; GO:0043171; GO:0070062; GO:0070573 0 0 cd05646; PF07687;PF01546; Q99ME2 CHOYP_LOC100561297.1.1 m.53787 sp WDR6_MOUSE 31.842 380 227 10 1 368 152 511 1.29E-55 199 WDR6_MOUSE reviewed WD repeat-containing protein 6 (mWDR6) Wdr6 Mus musculus (Mouse) 1125 cell cycle arrest [GO:0007050]; negative regulation of autophagy [GO:0010507]; negative regulation of cell proliferation [GO:0008285] GO:0005737; GO:0007050; GO:0008285; GO:0010507; GO:0043234; GO:0044822 0 0 0 PF00400; Q9BRP7 CHOYP_LOC566022.1.1 m.11301 sp FDXA1_HUMAN 47.423 194 100 1 10 203 6 197 1.29E-52 192 FDXA1_HUMAN reviewed Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDX-ACDB domain-containing protein 1) FDXACB1 Homo sapiens (Human) 624 rRNA base methylation [GO:0070475]; tRNA processing [GO:0008033] GO:0000049; GO:0000287; GO:0005524; GO:0005737; GO:0008033; GO:0070042; GO:0070475 0 0 0 PF10354;PF03147; Q9BZE4 CHOYP_CPIPJ_CPIJ004960.1.1 m.19349 sp NOG1_HUMAN 61.044 249 96 1 12 260 230 477 1.29E-96 300 NOG1_HUMAN reviewed Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB) GTPBP4 CRFG NOG1 Homo sapiens (Human) 634 negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of collagen binding [GO:0033342]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; protein stabilization [GO:0050821]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; ribosome biogenesis [GO:0042254] GO:0000079; GO:0001649; GO:0003924; GO:0005525; GO:0005634; GO:0005730; GO:0005737; GO:0005794; GO:0008156; GO:0008285; GO:0016020; GO:0022408; GO:0030336; GO:0031397; GO:0031965; GO:0033342; GO:0042254; GO:0044822; GO:0048471; GO:0050821 0 0 0 PF06858;PF08155; Q9DAR0 CHOYP_LOC100369902.1.1 m.64020 sp CE049_MOUSE 38.06 134 70 2 13 141 43 168 1.29E-21 88.6 CE049_MOUSE reviewed Uncharacterized protein C5orf49 homolog (Y regulated sperm protein) 0 Mus musculus (Mouse) 182 0 0 0 0 0 PF15074; Q9ESS0 CHOYP_PHUM_PHUM490910.1.1 m.28254 sp DUS10_MOUSE 50.149 335 142 4 89 402 153 483 1.29E-108 330 DUS10_MOUSE reviewed Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5) Dusp10 Mkp5 Mus musculus (Mouse) 483 inactivation of MAPK activity [GO:0000188]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of respiratory burst involved in inflammatory response [GO:0060266]; negative regulation of stress-activated MAPK cascade [GO:0032873]; oligodendrocyte differentiation [GO:0048709]; protein dephosphorylation [GO:0006470]; regulation of adaptive immune response [GO:0002819]; regulation of brown fat cell differentiation [GO:0090335]; regulation of innate immune response [GO:0045088]; response to lipopolysaccharide [GO:0032496] GO:0000188; GO:0002819; GO:0004725; GO:0005654; GO:0005794; GO:0006470; GO:0016791; GO:0017017; GO:0032496; GO:0032873; GO:0033549; GO:0043508; GO:0044387; GO:0045088; GO:0046329; GO:0048709; GO:0048715; GO:0060266; GO:0090335 0 0 0 PF00782;PF00581; Q9GZT4 CHOYP_DAR1.3.4 m.37921 sp SRR_HUMAN 48.78 205 103 1 1 203 1 205 1.29E-59 193 SRR_HUMAN reviewed Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) SRR Homo sapiens (Human) 340 aging [GO:0007568]; brain development [GO:0007420]; D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; pyruvate biosynthetic process [GO:0042866]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to morphine [GO:0043278]; serine family amino acid metabolic process [GO:0009069] GO:0000287; GO:0003941; GO:0005509; GO:0005524; GO:0005737; GO:0005886; GO:0006563; GO:0007420; GO:0007568; GO:0008721; GO:0009069; GO:0016594; GO:0018114; GO:0030165; GO:0030170; GO:0030378; GO:0032496; GO:0042493; GO:0042803; GO:0042866; GO:0043025; GO:0043278; GO:0045177; GO:0051289; GO:0070178; GO:0070179 0 0 0 PF00291; Q9NPL8 CHOYP_DANA_GF18787.1.1 m.19647 sp TIDC1_HUMAN 24.885 217 146 5 71 275 52 263 1.29E-11 67 TIDC1_HUMAN reviewed "Complex I assembly factor TIMMDC1, mitochondrial (Protein M5-14) (Translocase of inner mitochondrial membrane domain-containing protein 1) (TIMM domain containing-protein 1)" TIMMDC1 C3orf1 UNQ247/PRO284 Homo sapiens (Human) 285 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005654; GO:0005739; GO:0005743; GO:0016021; GO:0032981 0 0 0 PF02466; Q9NRA2 CHOYP_VGLU2.3.3 m.64250 sp S17A5_HUMAN 37.008 127 79 1 3 129 363 488 1.29E-21 98.2 S17A5_HUMAN reviewed Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) 495 amino acid transport [GO:0006865]; anion transport [GO:0006820]; ion transport [GO:0006811]; sialic acid transport [GO:0015739] GO:0005351; GO:0005737; GO:0005765; GO:0005886; GO:0005887; GO:0006811; GO:0006820; GO:0006865; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0030054; GO:0030672 0 0 cd06174; PF07690; Q9VHN6 CHOYP_LOC100650552.1.1 m.44153 sp RM19_DROME 48.585 212 107 2 90 301 66 275 1.29E-61 201 RM19_DROME reviewed "39S ribosomal protein L19, mitochondrial (L19mt) (MRP-L19)" mRpL19 CG8039 Drosophila melanogaster (Fruit fly) 306 sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0003735; GO:0005762; GO:0006412; GO:0019233 0 0 0 PF01245; Q9VHN6 CHOYP_ND5.3.6 m.34250 sp RM19_DROME 48.585 212 107 2 90 301 66 275 1.29E-61 201 RM19_DROME reviewed "39S ribosomal protein L19, mitochondrial (L19mt) (MRP-L19)" mRpL19 CG8039 Drosophila melanogaster (Fruit fly) 306 sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0003735; GO:0005762; GO:0006412; GO:0019233 0 0 0 PF01245; A1A4M4 CHOYP_TATD3.1.2 m.12974 sp TATD3_BOVIN 55.72 271 120 0 1 271 1 271 1.30E-101 300 TATD3_BOVIN reviewed Putative deoxyribonuclease TATDN3 (EC 3.1.21.-) TATDN3 Bos taurus (Bovine) 273 0 GO:0004518; GO:0005634; GO:0046872 0 0 0 PF01026; A2BFC9 CHOYP_BRAFLDRAFT_263840.1.1 m.51673 sp CFA77_DANRE 37.692 260 131 8 59 315 6 237 1.30E-45 157 CFA77_DANRE reviewed Cilia- and flagella-associated protein 77 cfap77 si:ch211-215c18.4 Danio rerio (Zebrafish) (Brachydanio rerio) 240 0 0 0 0 0 PF14825; B2GV54 CHOYP_BRAFLDRAFT_93072.1.1 m.10986 sp NCEH1_RAT 34.08 402 235 12 60 447 23 408 1.30E-63 213 NCEH1_RAT reviewed Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1) Nceh1 Aadacl1 Rattus norvegicus (Rat) 408 lipid catabolic process [GO:0016042]; protein dephosphorylation [GO:0006470]; SMAD protein signal transduction [GO:0060395]; xenobiotic metabolic process [GO:0006805] GO:0005783; GO:0006470; GO:0006805; GO:0016021; GO:0016042; GO:0017171; GO:0042301; GO:0052689; GO:0060395 0 0 0 PF07859; O08590 CHOYP_LOC100548064.1.1 m.40289 sp AOC3_RAT 27.567 711 457 19 67 759 50 720 1.30E-67 241 AOC3_RAT reviewed Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (Semicarbazide-sensitive amine oxidase) (SSAO) (VP97) (Vascular adhesion protein 1) (VAP-1) Aoc3 Rattus norvegicus (Rat) 763 aging [GO:0007568]; amine metabolic process [GO:0009308]; cell adhesion [GO:0007155]; eating behavior [GO:0042755]; leukocyte migration involved in inflammatory response [GO:0002523]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of glucose transport [GO:0010828]; positive regulation of leukocyte migration [GO:0002687]; regulation of blood pressure [GO:0008217]; response to immobilization stress [GO:0035902] GO:0002523; GO:0002675; GO:0002687; GO:0005507; GO:0005615; GO:0005886; GO:0007155; GO:0007568; GO:0008131; GO:0008217; GO:0009308; GO:0009986; GO:0010828; GO:0016021; GO:0035902; GO:0042755; GO:0042803; GO:0043231; GO:0048038; GO:0052593; GO:0052594; GO:0052595; GO:0052596 0 0 0 PF01179;PF02727;PF02728; O08989 CHOYP_LOC100748982.1.1 m.47037 sp RASM_MOUSE 74.854 171 43 0 4 174 8 178 1.30E-82 246 RASM_MOUSE reviewed Ras-related protein M-Ras (Muscle and microspikes Ras) (Ras-related protein R-Ras3) (X-Ras) Mras Xras Mus musculus (Mouse) 208 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030742; GO:0070062 0 0 0 PF00071; O35125 CHOYP_BRAFLDRAFT_223476.1.1 m.30983 sp LRC23_MOUSE 56.25 304 131 2 26 329 21 322 1.30E-113 336 LRC23_MOUSE reviewed Leucine-rich repeat-containing protein 23 (Leucine-rich protein B7) Lrrc23 Lrpb7 Mus musculus (Mouse) 340 0 0 0 0 0 PF13516; O43581 CHOYP_SYT7.1.1 m.17757 sp SYT7_HUMAN 47.013 385 189 3 137 521 33 402 1.30E-115 350 SYT7_HUMAN reviewed Synaptotagmin-7 (IPCA-7) (Prostate cancer-associated protein 7) (Synaptotagmin VII) (SytVII) SYT7 PCANAP7 Homo sapiens (Human) 403 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; calcium ion regulated lysosome exocytosis [GO:1990927]; phagocytosis [GO:0006909]; phagosome-lysosome fusion [GO:0090385]; plasma membrane repair [GO:0001778]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of bone remodeling [GO:0046850]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of glucagon secretion [GO:0070092]; regulation of insulin secretion [GO:0050796]; regulation of phagocytosis [GO:0050764]; short-term synaptic potentiation [GO:1990926]; synaptic vesicle recycling [GO:0036465]; vesicle fusion [GO:0006906]; vesicle-mediated cholesterol transport [GO:0090119] GO:0001778; GO:0005509; GO:0005516; GO:0005544; GO:0005546; GO:0005764; GO:0005765; GO:0005777; GO:0005778; GO:0005829; GO:0005886; GO:0006906; GO:0006909; GO:0008021; GO:0016021; GO:0017158; GO:0019905; GO:0030054; GO:0030276; GO:0030670; GO:0030672; GO:0031045; GO:0032009; GO:0036465; GO:0042734; GO:0043195; GO:0045956; GO:0046850; GO:0048791; GO:0050764; GO:0050796; GO:0070062; GO:0070092; GO:0090119; GO:0090385; GO:1990926; GO:1990927 0 0 0 PF00168; O43736 CHOYP_CG3662.2.2 m.49621 sp ITM2A_HUMAN 33.333 129 74 4 39 161 97 219 1.30E-14 73.6 ITM2A_HUMAN reviewed Integral membrane protein 2A (Protein E25) ITM2A UNQ603/PRO1189 Homo sapiens (Human) 263 negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399] GO:0001540; GO:0005794; GO:0005886; GO:0007399; GO:0016021; GO:0042985; GO:0070062 0 0 0 PF04089; O70277 CHOYP_BRAFLDRAFT_99973.8.8 m.64642 sp TRIM3_RAT 25.333 150 105 3 29 176 599 743 1.30E-08 57 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O76387 CHOYP_LOC100898860.1.1 m.7386 sp PTH2_CAEEL 39.362 188 108 4 14 198 132 316 1.30E-30 117 PTH2_CAEEL reviewed Probable peptidyl-tRNA hydrolase 2 (PTH 2) (EC 3.1.1.29) C24G6.8 Caenorhabditis elegans 316 0 GO:0004045 0 0 0 PF01981;PF00627; P10079 CHOYP_NOTC2.4.5 m.54441 sp FBP1_STRPU 44.327 379 211 0 487 865 172 550 1.30E-94 335 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P18293 CHOYP_LOC100197876.1.1 m.45271 sp ANPRA_MOUSE 42.857 644 311 11 1051 1674 446 1052 1.30E-154 504 ANPRA_MOUSE reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Npra Mus musculus (Mouse) 1057 cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood vessel size [GO:0050880] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0006182; GO:0007168; GO:0008074; GO:0016021; GO:0016941; GO:0017046; GO:0030828; GO:0035556; GO:0042417; GO:0042562; GO:0043235; GO:0048662; GO:0050880 0 0 0 PF01094;PF00211;PF07714; P20009 CHOYP_DLX1.1.1 m.56431 sp DLL_DROME 60.335 179 43 8 16 183 28 189 1.30E-49 171 DLL_DROME reviewed Homeotic protein distal-less (Protein brista) Dll Ba BR CG3629 Drosophila melanogaster (Fruit fly) 327 "analia development [GO:0007487]; antennal development [GO:0007469]; determination of ventral identity [GO:0048264]; genital disc development [GO:0035215]; imaginal disc-derived appendage morphogenesis [GO:0035114]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived male genitalia development [GO:0007485]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; leg disc proximal/distal pattern formation [GO:0007479]; mushroom body development [GO:0016319]; negative regulation of gene expression [GO:0010629]; olfactory behavior [GO:0042048]; olfactory nerve development [GO:0021553]; positive regulation of transcription, DNA-templated [GO:0045893]; proboscis development [GO:0048728]; proximal/distal pattern formation, imaginal disc [GO:0007449]; specification of organ identity [GO:0010092]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0007449; GO:0007469; GO:0007479; GO:0007480; GO:0007485; GO:0007487; GO:0008587; GO:0010092; GO:0010629; GO:0016319; GO:0021553; GO:0035114; GO:0035215; GO:0042048; GO:0043565; GO:0045893; GO:0048264; GO:0048728 0 0 0 PF00046; P21439 CHOYP_MDR3.1.3 m.5938 sp MDR3_HUMAN 40.686 204 83 2 44 247 28 193 1.30E-38 145 MDR3_HUMAN reviewed Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 3) ABCB4 MDR3 PGY3 Homo sapiens (Human) 1286 "antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent [GO:0002489]; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent [GO:0002485]; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481]; bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; phospholipid translocation [GO:0045332]; positive regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002591]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to drug [GO:0042493]; response to fenofibrate [GO:1901557]; transmembrane transport [GO:0055085]; transport [GO:0006810]" GO:0002481; GO:0002485; GO:0002489; GO:0002591; GO:0005524; GO:0005548; GO:0005737; GO:0005886; GO:0005887; GO:0006629; GO:0006810; GO:0008525; GO:0008559; GO:0016020; GO:0016324; GO:0030136; GO:0032376; GO:0032782; GO:0042493; GO:0042626; GO:0045121; GO:0045332; GO:0046581; GO:0055085; GO:0055088; GO:0061092; GO:0070062; GO:0090554; GO:1901557; GO:1903413; GO:2001140 0 0 0 PF00664;PF00005; P21941 CHOYP_MATN1.3.5 m.46206 sp MATN1_HUMAN 29.787 423 247 10 25 406 39 452 1.30E-47 183 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P24014 CHOYP_BRAFLDRAFT_69264.5.6 m.52955 sp SLIT_DROME 36.029 136 77 2 1 133 181 309 1.30E-18 87.4 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P27502 CHOYP_CRE_11685.1.2 m.10222 sp POL_RTBVP 22.038 422 272 16 348 746 1238 1625 1.30E-10 69.3 POL_RTBVP reviewed Polyprotein P3 (P194 protein) [Cleaved into: Putative movement protein (MP); Capsid protein (Coat protein) (CP); Protease (PR) (EC 3.4.23.-); Reverse transcriptase/Ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4) (p55)] 0 Rice tungro bacilliform virus (isolate Philippines) (RTBV) 1675 "transport of virus in host, cell to cell [GO:0046740]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]" GO:0003676; GO:0003964; GO:0004190; GO:0004523; GO:0019028; GO:0042025; GO:0046718; GO:0046740; GO:0046872; GO:0075732 0 0 0 PF01107;PF00078; P30151 CHOYP_EF1B.7.7 m.66919 sp EF1B_XENLA 63.38 213 71 2 25 230 1 213 1.30E-86 259 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P32577 CHOYP_PHUM_PHUM048780.1.1 m.24840 sp CSK_RAT 57.184 348 141 5 48 392 103 445 1.30E-139 408 CSK_RAT reviewed Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) Csk Rattus norvegicus (Rat) 450 adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; brain development [GO:0007420]; cell migration [GO:0016477]; cellular response to peptide hormone stimulus [GO:0071375]; innate immune response [GO:0045087]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of kinase activity [GO:0033673]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of MAP kinase activity [GO:0043406]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0002250; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005737; GO:0005911; GO:0006468; GO:0007169; GO:0007420; GO:0008285; GO:0010989; GO:0016477; GO:0019903; GO:0031234; GO:0032715; GO:0033673; GO:0034332; GO:0038083; GO:0042997; GO:0043406; GO:0045087; GO:0045121; GO:0045779; GO:0046777; GO:0046872; GO:0048709; GO:0050765; GO:0060368; GO:0070062; GO:0070064; GO:0070373; GO:0071375 0 0 0 PF07714;PF00017;PF00018; P40338 CHOYP_VHL.1.1 m.250 sp VHL_MOUSE 28.289 152 104 2 3 150 10 160 1.30E-12 65.5 VHL_MOUSE reviewed Von Hippel-Lindau disease tumor suppressor (pVHL) Vhl Vhlh Mus musculus (Mouse) 181 "angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; camera-type eye morphogenesis [GO:0048593]; ciliary body morphogenesis [GO:0061073]; extracellular matrix organization [GO:0030198]; eye pigmentation [GO:0048069]; homeostasis of number of retina cells [GO:0048877]; iris morphogenesis [GO:0061072]; melanin metabolic process [GO:0006582]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of gene expression [GO:0010629]; negative regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902072]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; neuron differentiation [GO:0030182]; NLS-bearing protein import into nucleus [GO:0006607]; pancreatic A cell differentiation [GO:0003310]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasomal protein catabolic process [GO:0010498]; protein catabolic process [GO:0030163]; protein heterooligomerization [GO:0051291]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of catecholamine metabolic process [GO:0042069]; regulation of cellular protein localization [GO:1903827]; regulation of gene expression [GO:0010468]; regulation of thymocyte apoptotic process [GO:0070243]; regulation of transcription, DNA-templated [GO:0006355]; response to ethanol [GO:0045471]; type B pancreatic cell differentiation [GO:0003309]" GO:0001525; GO:0003309; GO:0003310; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0005829; GO:0005929; GO:0006355; GO:0006582; GO:0006607; GO:0008134; GO:0010468; GO:0010498; GO:0010629; GO:0015031; GO:0016020; GO:0016567; GO:0019899; GO:0030163; GO:0030182; GO:0030198; GO:0030891; GO:0031462; GO:0032403; GO:0042069; GO:0043534; GO:0045471; GO:0045602; GO:0045893; GO:0048069; GO:0048593; GO:0048877; GO:0050679; GO:0051291; GO:0061072; GO:0061073; GO:0061428; GO:0061630; GO:0070243; GO:0070244; GO:1902072; GO:1903827; GO:2001233 PATHWAY: Protein modification; protein ubiquitination. 0 cd05468; PF01847;PF17211; P41339 CHOYP_ACT.24.27 m.63923 sp ACTA_LIMPO 96.774 217 7 0 17 233 160 376 1.30E-156 442 ACTA_LIMPO reviewed "Actin, acrosomal process isoform (Actin-5)" 0 Limulus polyphemus (Atlantic horseshoe crab) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P49395 CHOYP_RS3A.12.15 m.49134 sp RS3A_APLCA 69.531 128 35 2 15 139 139 265 1.30E-58 185 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P57721 CHOYP_ISCW_ISCW016289.1.1 m.12312 sp PCBP3_HUMAN 61.145 332 107 5 18 343 46 361 1.30E-129 382 PCBP3_HUMAN reviewed Poly(rC)-binding protein 3 (Alpha-CP3) PCBP3 Homo sapiens (Human) 371 mRNA metabolic process [GO:0016071] GO:0003677; GO:0003723; GO:0005634; GO:0005829; GO:0016071; GO:0030529; GO:0044822; GO:0070062 0 0 0 PF00013; P61859 CHOYP_TSTA_044140.1.1 m.52039 sp CALM_NEUCR 43.357 143 75 2 24 165 12 149 1.30E-34 121 CALM_NEUCR reviewed Calmodulin (CaM) cmd-1 cmd1 94C8.160 NCU04120 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 149 0 GO:0005509 0 0 0 PF13499; P67985 CHOYP_RL22.4.4 m.37418 sp RL22_PIG 77.273 110 24 1 14 122 9 118 1.30E-48 155 RL22_PIG reviewed 60S ribosomal protein L22 (Heparin-binding protein HBp15) RPL22 Sus scrofa (Pig) 128 alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181] GO:0002181; GO:0003723; GO:0003735; GO:0008201; GO:0022625; GO:0046632 0 0 0 PF01776; P86954 CHOYP_RS9.9.13 m.44486 sp ELDP2_PINMA 41.918 365 197 9 1 362 5 357 1.30E-84 263 ELDP2_PINMA reviewed EGF-like domain-containing protein 2 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 357 0 GO:0005576 0 0 0 0 P97864 CHOYP_CASP10.7.7 m.64337 sp CASP7_MOUSE 24.224 322 170 12 2 316 45 299 1.30E-08 58.9 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q05893 CHOYP_PCK-1.1.1 m.1480 sp PCKG_ASCSU 68.919 222 69 0 5 226 418 639 1.30E-115 346 PCKG_ASCSU reviewed Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) PEPCK Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 643 gluconeogenesis [GO:0006094] GO:0004613; GO:0005525; GO:0006094; GO:0046872 0 0 0 PF00821; Q09575 CHOYP_LOC586954.1.1 m.60792 sp YRD6_CAEEL 25.553 407 262 9 250 622 241 640 1.30E-26 119 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q09660 CHOYP_LOC100374454.1.1 m.1321 sp CC44_CAEEL 27.962 211 141 5 15 223 129 330 1.30E-19 90.9 CC44_CAEEL reviewed Probable cytochrome P450 CYP44 (EC 1.14.-.-) cyp-44A1 ccp-44 cyp44 ZK177.5 Caenorhabditis elegans 489 0 GO:0004497; GO:0005506; GO:0016491; GO:0016705; GO:0020037 0 0 0 PF00067; Q0EEE2 CHOYP_LOC100372915.5.7 m.50977 sp PTHD3_MOUSE 28.873 852 546 18 9 823 77 905 1.30E-112 368 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q0MQD8 CHOYP_DGRI_GH15309.1.1 m.15570 sp NDUB5_PANTR 37.705 122 70 4 73 190 61 180 1.30E-15 75.5 NDUB5_PANTR reviewed "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)" NDUFB5 Pan troglodytes (Chimpanzee) 189 oxidation-reduction process [GO:0055114] GO:0005654; GO:0005747; GO:0016021; GO:0055114 0 0 0 PF09781; Q14980 CHOYP_TVAG_087170.2.8 m.17174 sp NUMA1_HUMAN 24.795 488 223 20 1531 1895 1476 1942 1.30E-11 74.3 NUMA1_HUMAN reviewed Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) 2115 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997] GO:0000132; GO:0000139; GO:0000922; GO:0005198; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005876; GO:0005938; GO:0006997; GO:0007067; GO:0016363; GO:0030425; GO:0043025; GO:0045177; GO:0051301; GO:0051321; GO:0060487; GO:0061673; GO:0070062; GO:0072686; GO:0097431 0 0 0 0 Q17RP2 CHOYP_LOC100162439.1.1 m.19182 sp TIGD6_HUMAN 29.142 501 317 11 618 1089 3 494 1.30E-66 237 TIGD6_HUMAN reviewed Tigger transposable element-derived protein 6 TIGD6 Homo sapiens (Human) 521 0 GO:0003677; GO:0005634 0 0 0 PF04218;PF03184;PF03221; Q24K15 CHOYP_LOC100639584.1.3 m.21132 sp ANGP4_BOVIN 38.683 243 138 6 61 300 261 495 1.30E-56 192 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q26627 CHOYP_REJ3.1.1 m.66142 sp SUREJ_STRPU 25 224 130 9 22 230 708 908 1.30E-06 53.9 SUREJ_STRPU reviewed Sperm receptor for egg jelly (suREJ) REJ Strongylocentrotus purpuratus (Purple sea urchin) 1450 detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0005886; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF00008;PF01825;PF00059;PF02010; Q2EMV9 CHOYP_LOC100487912.3.3 m.56361 sp PAR14_MOUSE 28.623 276 162 6 768 1025 1035 1293 1.30E-18 97.1 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q2KIN5 CHOYP_HEM3.1.1 m.28414 sp HEM3_BOVIN 49.123 342 169 2 5 346 19 355 1.30E-107 322 HEM3_BOVIN reviewed Porphobilinogen deaminase (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) HMBS Bos taurus (Bovine) 361 peptidyl-pyrromethane cofactor linkage [GO:0018160]; protoporphyrinogen IX biosynthetic process [GO:0006782] GO:0004418; GO:0006782; GO:0018160 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. 0 0 PF01379;PF03900; Q2TBS4 CHOYP_BRAFLDRAFT_128029.1.1 m.63515 sp PIFO_BOVIN 35.385 195 117 3 2 194 5 192 1.30E-28 108 PIFO_BOVIN reviewed Protein pitchfork PIFO Bos taurus (Bovine) 192 cell projection organization [GO:0030030]; positive regulation of kinase activity [GO:0033674]; regulation of cell projection organization [GO:0031344] GO:0005802; GO:0016023; GO:0030030; GO:0031344; GO:0033674; GO:0036064 0 0 0 0 Q2XNC8 CHOYP_BRAFLDRAFT_116025.2.2 m.52774 sp CP2D6_PANTR 28.75 320 201 8 33 337 177 484 1.30E-37 144 CP2D6_PANTR reviewed Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (Cholesterol 25-hydroxylase) CYP2D6 Pan troglodytes (Chimpanzee) 497 arachidonic acid metabolic process [GO:0019369]; steroid metabolic process [GO:0008202] GO:0005506; GO:0005789; GO:0008202; GO:0008392; GO:0008395; GO:0019369; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q3SWY8 CHOYP_ZUFSP.1.1 m.42946 sp ZUFSP_BOVIN 43.455 382 186 8 18 376 194 568 1.30E-98 307 ZUFSP_BOVIN reviewed Zinc finger with UFM1-specific peptidase domain protein ZUFSP Bos taurus (Bovine) 579 0 GO:0046872 0 0 0 PF07910; Q3SZQ6 CHOYP_BRAFLDRAFT_114866.3.5 m.17970 sp RL32_BOVIN 77.444 133 30 0 2 134 3 135 1.30E-74 221 RL32_BOVIN reviewed 60S ribosomal protein L32 RPL32 Bos taurus (Bovine) 135 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 cd00513; PF01655; Q3U595 CHOYP_DMOJ_GI19292.1.1 m.12058 sp CV039_MOUSE 31.25 96 61 2 39 134 11 101 1.30E-06 48.1 CV039_MOUSE reviewed UPF0545 protein C22orf39 homolog 0 Mus musculus (Mouse) 105 0 0 0 0 0 PF11326; Q460N5 CHOYP_BRAFLDRAFT_84838.6.6 m.66693 sp PAR14_HUMAN 24.415 897 626 17 703 1580 192 1055 1.30E-65 250 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4ZJM9 CHOYP_LOC100693208.2.8 m.3421 sp C1QL4_MOUSE 33.929 112 61 3 182 288 110 213 1.30E-08 58.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q58EK5 CHOYP_BRAFLDRAFT_125037.1.3 m.2939 sp TDRD1_DANRE 25.289 866 504 29 1882 2670 195 994 1.30E-50 202 TDRD1_DANRE reviewed Tudor domain-containing protein 1 tdrd1 im:7155161 Danio rerio (Zebrafish) (Brachydanio rerio) 1175 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; P granule organization [GO:0030719]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0005737; GO:0007281; GO:0007283; GO:0030719; GO:0031047; GO:0034584; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; Q5DW34 CHOYP_AFUA_1G01020.50.50 m.66481 sp EHMT1_MOUSE 34.328 134 87 1 243 375 766 899 1.30E-18 91.3 EHMT1_MOUSE reviewed Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) 1296 "chromatin modification [GO:0016568]; DNA methylation [GO:0006306]; embryo development [GO:0009790]; histone methylation [GO:0016571]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; response to fungicide [GO:0060992]" GO:0000122; GO:0002039; GO:0005634; GO:0005654; GO:0005694; GO:0006306; GO:0008168; GO:0008270; GO:0009790; GO:0016279; GO:0016568; GO:0016571; GO:0018024; GO:0018026; GO:0018027; GO:0045892; GO:0046974; GO:0046976; GO:0060992; GO:0070742 0 0 0 PF12796;PF05033;PF00856; Q5RKI3 CHOYP_BRAFLDRAFT_235602.1.1 m.50985 sp DPOLL_RAT 46.474 553 255 9 21 548 36 572 1.30E-160 472 DPOLL_RAT reviewed DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) Poll Rattus norvegicus (Rat) 573 DNA replication [GO:0006260]; nucleotide-excision repair [GO:0006289] GO:0003677; GO:0003887; GO:0005634; GO:0006260; GO:0006289; GO:0016829; GO:0046872 0 0 cd00141; PF14792;PF14791;PF10391;PF14716; Q5SQS7 CHOYP_SH24B.1.1 m.49862 sp SH24B_HUMAN 38.544 467 226 12 1 443 1 430 1.30E-76 248 SH24B_HUMAN reviewed SH2 domain-containing protein 4B SH2D4B Homo sapiens (Human) 431 0 0 0 0 0 PF00017; Q5XI81 CHOYP_FMRP.2.2 m.44866 sp FXR1_RAT 56 400 162 6 1 398 1 388 1.30E-152 457 FXR1_RAT reviewed Fragile X mental retardation syndrome-related protein 1 Fxr1 Fxr1h Rattus norvegicus (Rat) 568 cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of translation [GO:0017148]; positive regulation of gene silencing by miRNA [GO:2000637] GO:0003729; GO:0005634; GO:0005737; GO:0005844; GO:0007517; GO:0017148; GO:0030154; GO:0033592; GO:0042803; GO:0046982; GO:2000637 0 0 0 PF05641;PF12235;PF16096;PF00013; Q5XPI4 CHOYP_LOC101163564.1.1 m.12630 sp RN123_HUMAN 35.749 207 118 5 1 203 263 458 1.30E-30 124 RN123_HUMAN reviewed E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) RNF123 KPC1 FP1477 Homo sapiens (Human) 1314 protein ubiquitination [GO:0016567] GO:0005737; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622; Q62158 CHOYP_BRAFLDRAFT_88223.17.22 m.60182 sp TRI27_MOUSE 25.498 251 152 8 10 234 53 294 1.30E-06 54.3 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q647I9 CHOYP_NAL14.1.1 m.66331 sp NALP5_BOVIN 29.897 291 200 4 416 702 743 1033 1.30E-28 126 NALP5_BOVIN reviewed "NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog)" NLRP5 MATER NALP5 Bos taurus (Bovine) 1098 0 GO:0005524; GO:0005730; GO:0005737; GO:0005739; GO:0005829; GO:0005938; GO:0042585; GO:0048471 0 0 0 PF13516;PF02758; Q68EZ3 CHOYP_LOC591167.1.1 m.30169 sp ANM6_XENLA 49.846 325 160 2 35 356 14 338 1.30E-115 342 ANM6_XENLA reviewed Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT6) prmt6 Xenopus laevis (African clawed frog) 340 "DNA repair [GO:0006281]; histone H3-R2 methylation [GO:0034970]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006281; GO:0006351; GO:0019919; GO:0034970; GO:0035241; GO:0035242; GO:0042054; GO:0042393; GO:0044020; GO:0045892; GO:0070611; GO:0070612 0 0 0 PF05185; Q68F64 CHOYP_ISCW_ISCW018499.1.1 m.37879 sp UN45B_XENLA 44.211 190 103 2 7 196 7 193 1.30E-42 157 UN45B_XENLA reviewed Protein unc-45 homolog B (Unc-45B) unc45b cmya4 Xenopus laevis (African clawed frog) 927 cell differentiation [GO:0030154]; lens development in camera-type eye [GO:0002088]; muscle organ development [GO:0007517] GO:0002088; GO:0005829; GO:0007517; GO:0030154 0 0 0 PF13181;PF11701; Q6AX44 CHOYP_TL5A.1.3 m.19334 sp FBCDA_XENLA 52.632 171 67 4 71 228 282 451 1.30E-49 171 FBCDA_XENLA reviewed Fibrinogen C domain-containing protein 1-A fibcd1-a Xenopus laevis (African clawed frog) 457 0 GO:0008061; GO:0016021; GO:0046872 0 0 0 PF00147; Q6AYQ3 CHOYP_BRAFLDRAFT_126779.1.1 m.50577 sp SYFM_RAT 53.409 88 41 0 61 148 51 138 1.30E-25 103 SYFM_RAT reviewed "Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)" Fars2 Fars1 Rattus norvegicus (Rat) 472 phenylalanyl-tRNA aminoacylation [GO:0006432]; tRNA processing [GO:0008033] GO:0000049; GO:0000287; GO:0004826; GO:0005524; GO:0005739; GO:0005759; GO:0006432; GO:0008033 0 0 0 PF03147;PF01409; Q6DFV3 CHOYP_ARHGAP21.1.1 m.8587 sp RHG21_MOUSE 38.998 559 267 15 866 1374 924 1458 1.30E-97 355 RHG21_MOUSE reviewed Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) Arhgap21 Arhgap10 Kiaa1424 Mus musculus (Mouse) 1944 establishment of Golgi localization [GO:0051683]; Golgi localization [GO:0051645]; Golgi organization [GO:0007030]; maintenance of Golgi location [GO:0051684]; organelle transport along microtubule [GO:0072384]; positive regulation of GTPase activity [GO:0043547]; regulation of endocytosis [GO:0030100]; signal transduction [GO:0007165] GO:0000139; GO:0005096; GO:0005794; GO:0005856; GO:0005886; GO:0007030; GO:0007165; GO:0030054; GO:0030100; GO:0030659; GO:0043547; GO:0051645; GO:0051683; GO:0051684; GO:0072384 0 0 0 PF00595;PF00620; Q6DFV8 CHOYP_BRAFLDRAFT_67520.1.2 m.16093 sp VWDE_MOUSE 28.795 448 271 19 22 451 217 634 1.30E-41 166 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q7ZTY6 CHOYP_BRAFLDRAFT_93665.1.1 m.10941 sp CG026_DANRE 32.295 353 204 13 63 387 37 382 1.30E-38 147 CG026_DANRE reviewed Uncharacterized protein C7orf26 homolog zgc:56409 Danio rerio (Zebrafish) (Brachydanio rerio) 475 0 0 0 0 0 PF14964; Q80YX1 CHOYP_ANGL7.1.1 m.66381 sp TENA_MOUSE 42.18 211 117 3 307 517 1892 2097 1.30E-47 181 TENA_MOUSE reviewed Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) 2110 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] GO:0001649; GO:0001968; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; Q8BGS1 CHOYP_AGAP_AGAP004136.1.3 m.24172 sp E41L5_MOUSE 67.257 339 111 0 31 369 40 378 1.30E-165 507 E41L5_MOUSE reviewed Band 4.1-like protein 5 Epb41l5 Epb4.1l5 Kiaa1548 Mus musculus (Mouse) 731 "actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; apical constriction [GO:0003383]; axial mesoderm development [GO:0048318]; axial mesoderm morphogenesis [GO:0048319]; cell morphogenesis involved in differentiation [GO:0000904]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ectoderm development [GO:0007398]; embryonic foregut morphogenesis [GO:0048617]; endoderm development [GO:0007492]; epithelial cell morphogenesis [GO:0003382]; epithelial to mesenchymal transition [GO:0001837]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mesoderm development [GO:0007498]; mesoderm migration involved in gastrulation [GO:0007509]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of protein binding [GO:0032091]; neural plate morphogenesis [GO:0001839]; paraxial mesoderm development [GO:0048339]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of protein binding [GO:0032092]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of establishment of protein localization [GO:0070201]; somite rostral/caudal axis specification [GO:0032525]; somitogenesis [GO:0001756]; substrate-dependent cell migration, cell attachment to substrate [GO:0006931]; unidimensional cell growth [GO:0009826]" GO:0000904; GO:0001701; GO:0001756; GO:0001837; GO:0001839; GO:0001954; GO:0003382; GO:0003383; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0005925; GO:0006931; GO:0007398; GO:0007492; GO:0007498; GO:0007509; GO:0009826; GO:0010608; GO:0010634; GO:0010718; GO:0019898; GO:0019904; GO:0022408; GO:0030036; GO:0031032; GO:0031252; GO:0032091; GO:0032092; GO:0032525; GO:0032587; GO:0048318; GO:0048319; GO:0048339; GO:0048617; GO:0051894; GO:0070201; GO:0070986; GO:0071560 0 0 0 PF08736;PF09380;PF00373;PF09379; Q8BYI8 CHOYP_BRAFLDRAFT_93831.2.3 m.18110 sp F234B_MOUSE 22.857 385 260 10 143 517 141 498 1.30E-20 100 F234B_MOUSE reviewed Protein FAM234B Fam234b Kiaa1467 Mus musculus (Mouse) 624 0 GO:0016021 0 0 0 0 Q8C5H1 CHOYP_DYAK_GE25120.1.2 m.831 sp ANO4_MOUSE 32.45 151 90 5 18 162 43 187 1.30E-16 79.7 ANO4_MOUSE reviewed Anoctamin-4 (Transmembrane protein 16D) Ano4 Tmem16d Mus musculus (Mouse) 955 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821] GO:0005622; GO:0005886; GO:0006821; GO:0016021; GO:0017128; GO:0061589; GO:0061590; GO:0061591; GO:1902476 0 0 0 PF16178;PF04547; Q8C9W3 CHOYP_LOC100076885.1.1 m.44437 sp ATS2_MOUSE 27.331 311 179 10 28 328 479 752 1.30E-26 114 ATS2_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) Adamts2 Mus musculus (Mouse) 1213 collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; lung development [GO:0030324]; protein processing [GO:0016485]; skin development [GO:0043588]; spermatogenesis [GO:0007283] GO:0004222; GO:0005578; GO:0007283; GO:0008233; GO:0008270; GO:0016485; GO:0030199; GO:0030324; GO:0030574; GO:0043588 0 0 0 PF05986;PF01562;PF01421;PF00090; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.26.34 m.56274 sp VWDE_HUMAN 24.691 648 362 28 10 586 8 600 1.30E-21 105 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N8L6 CHOYP_LOC100669904.1.1 m.5886 sp ARL10_HUMAN 40.659 91 50 3 1 91 138 224 1.30E-10 58.9 ARL10_HUMAN reviewed ADP-ribosylation factor-like protein 10 ARL10 ARL10A Homo sapiens (Human) 244 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF00025; Q8VHS2 CHOYP_LOC100376421.2.4 m.17471 sp CRUM1_MOUSE 41.667 84 33 3 391 472 155 224 1.30E-08 62.4 CRUM1_MOUSE reviewed Protein crumbs homolog 1 Crb1 Mus musculus (Mouse) 1405 eye photoreceptor cell development [GO:0042462]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009] GO:0005509; GO:0005886; GO:0005902; GO:0007009; GO:0016021; GO:0042462; GO:0061024 0 0 0 PF00008;PF12661;PF02210; Q8VI56 CHOYP_LRP1.4.5 m.33899 sp LRP4_MOUSE 26.759 867 575 24 115 952 514 1349 1.30E-86 316 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q8WRF3 CHOYP_ISCW_ISCW012366.1.1 m.3693 sp RL32_APIME 65.789 76 25 1 36 110 1 76 1.30E-27 101 RL32_APIME reviewed 60S ribosomal protein L32 (Ribosomal protein 49) RpL32 rp49 Apis mellifera (Honeybee) 134 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00513; PF01655; Q96MT7 CHOYP_LOC587715.1.1 m.66778 sp CFA44_HUMAN 63.043 368 134 1 186 553 105 470 1.30E-167 504 CFA44_HUMAN reviewed Cilia- and flagella-associated protein 44 (WD repeat-containing protein 52) CFAP44 WDR52 Homo sapiens (Human) 982 0 GO:0042995 0 0 0 PF00400; Q99996 CHOYP_AKAP9.9.9 m.52704 sp AKAP9_HUMAN 25.77 357 191 14 74 398 3587 3901 1.30E-09 64.3 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9BZE3 CHOYP_BARH2.1.1 m.55901 sp BARH1_HUMAN 60 125 44 2 92 214 144 264 1.30E-37 137 BARH1_HUMAN reviewed BarH-like 1 homeobox protein BARHL1 FKSG31 Homo sapiens (Human) 327 midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sensory perception of sound [GO:0007605] GO:0000977; GO:0001077; GO:0001228; GO:0001764; GO:0005634; GO:0006357; GO:0007605; GO:0030901; GO:0043524 0 0 0 PF00046; Q9CYU6 CHOYP_LOC101168963.1.2 m.38642 sp DPH7_MOUSE 42.73 337 176 7 26 355 13 339 1.30E-84 267 DPH7_MOUSE reviewed Diphthine methyltransferase (EC 3.1.1.97) (Diphthamide biosynthesis protein 7) (DPH7) (WD repeat-containing protein 85) Dph7 Wdr85 Mus musculus (Mouse) 477 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183] GO:0017183; GO:0061685 PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. 0 0 0 Q9D6F9 CHOYP_contig_015657 m.18312 sp TBB4A_MOUSE 66.667 120 36 2 1 118 16 133 1.30E-44 154 TBB4A_MOUSE reviewed Tubulin beta-4A chain (Tubulin beta-4 chain) Tubb4a Tubb4 Mus musculus (Mouse) 444 cell projection organization [GO:0030030]; microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005874; GO:0005929; GO:0007017; GO:0030030; GO:0033269; GO:0042995; GO:0043025; GO:0043209; GO:0070062 0 0 0 PF00091;PF03953; Q9ESN4 CHOYP_LOC100698726.8.8 m.59486 sp C1QL3_MOUSE 34.234 111 69 3 310 417 143 252 1.30E-09 62 C1QL3_MOUSE reviewed Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) 255 regulation of synapse organization [GO:0050807] GO:0005576; GO:0005581; GO:0050807 0 0 0 PF00386;PF01391; Q9ESN6 CHOYP_TRIM3.41.58 m.42426 sp TRIM2_MOUSE 31.053 190 101 7 71 248 536 707 1.30E-12 70.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TVAG_139760.2.2 m.65494 sp TRIM2_MOUSE 24.5 200 139 5 243 432 547 744 1.30E-07 57.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H1Q7 CHOYP_BRAFLDRAFT_126881.1.2 m.6483 sp PED1A_HUMAN 43.972 282 154 2 7 286 21 300 1.30E-90 285 PED1A_HUMAN reviewed PC-esterase domain-containing protein 1A (Protein FAM113A) (Sarcoma antigen NY-SAR-23) PCED1A C20orf81 FAM113A Homo sapiens (Human) 454 0 0 0 0 0 PF13839; Q9JLC8 CHOYP_NEMVEDRAFT_V1G247395.2.8 m.12867 sp SACS_MOUSE 25.316 474 286 22 2 420 4116 4576 1.30E-18 92.4 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_SACS.2.17 m.20008 sp SACS_MOUSE 22.721 779 530 26 1 730 444 1199 1.30E-29 130 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9MYM7 CHOYP_LOC552398.2.2 m.39852 sp B3GT1_PONPY 30.35 257 171 5 60 312 69 321 1.30E-40 147 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9NR09 CHOYP_BRAFLDRAFT_275787.1.2 m.15361 sp BIRC6_HUMAN 44.8 125 68 1 7 130 54 178 1.30E-28 112 BIRC6_HUMAN reviewed Baculoviral IAP repeat-containing protein 6 (EC 6.3.2.-) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON) BIRC6 KIAA1289 Homo sapiens (Human) 4857 apoptotic process [GO:0006915]; cell division [GO:0051301]; labyrinthine layer development [GO:0060711]; mitotic nuclear division [GO:0007067]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell proliferation [GO:0008284]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127]; regulation of cytokinesis [GO:0032465]; spongiotrophoblast layer development [GO:0060712] GO:0000922; GO:0004842; GO:0004869; GO:0005768; GO:0005802; GO:0005815; GO:0006468; GO:0006915; GO:0007067; GO:0008284; GO:0016020; GO:0016567; GO:0016874; GO:0030496; GO:0032465; GO:0042127; GO:0043066; GO:0051301; GO:0060711; GO:0060712; GO:0061631; GO:2001237 0 0 0 PF00653;PF12356;PF00179; Q9P2P6 CHOYP_LOC576766.1.1 m.55280 sp STAR9_HUMAN 28.947 190 126 7 471 657 4515 4698 1.30E-13 78.6 STAR9_HUMAN reviewed StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9) STARD9 KIAA1300 Homo sapiens (Human) 4700 cytoskeleton-dependent intracellular transport [GO:0030705]; metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225] GO:0003777; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005814; GO:0005871; GO:0007018; GO:0008017; GO:0008152; GO:0008289; GO:0016887; GO:0030705; GO:0051225 0 0 0 PF00498;PF00225;PF01852; Q9UA35 CHOYP_S28A3.3.3 m.14797 sp S28A3_EPTST 29.237 236 148 5 39 268 22 244 1.30E-17 85.5 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; Q9UEG4 CHOYP_LOC100535129.1.1 m.62626 sp ZN629_HUMAN 32.759 232 139 6 92 316 421 642 1.30E-25 115 ZN629_HUMAN reviewed Zinc finger protein 629 (Zinc finger protein 65) ZNF629 KIAA0326 ZNF65 Homo sapiens (Human) 869 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q9UPQ7 CHOYP_LOC593787.2.2 m.52148 sp PZRN3_HUMAN 26.174 149 103 5 30 172 37 184 1.30E-09 65.1 PZRN3_HUMAN reviewed E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) PDZRN3 KIAA1095 LNX3 SEMCAP3 Homo sapiens (Human) 1066 neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] GO:0004842; GO:0007528; GO:0008270; GO:0016567; GO:0016874; GO:0031594; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00595; Q9Y2I7 CHOYP_PIKFYVE.1.1 m.24571 sp FYV1_HUMAN 39.108 762 369 16 104 780 129 880 1.30E-147 512 FYV1_HUMAN reviewed 1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) PIKFYVE KIAA0981 PIP5K3 Homo sapiens (Human) 2098 "intracellular signal transduction [GO:0035556]; myelin assembly [GO:0032288]; phosphatidylinositol 5-phosphate metabolic process [GO:1904562]; phosphatidylinositol biosynthetic process [GO:0006661]; protein localization to nucleus [GO:0034504]; regulation of autophagosome assembly [GO:2000785]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000139; GO:0000285; GO:0005524; GO:0005829; GO:0005911; GO:0006661; GO:0008270; GO:0010008; GO:0012506; GO:0016308; GO:0031410; GO:0031901; GO:0031902; GO:0032288; GO:0034504; GO:0035556; GO:0042147; GO:0043813; GO:0045121; GO:0048471; GO:1904562; GO:2000785 0 0 0 PF00118;PF00610;PF01363;PF01504; Q9Y5Q5 CHOYP_CORIN.1.2 m.39887 sp CORIN_HUMAN 28.067 595 363 16 1372 1916 455 1034 1.30E-57 222 CORIN_HUMAN reviewed "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) 1042 female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] GO:0003050; GO:0004252; GO:0005576; GO:0005886; GO:0005887; GO:0007565; GO:0008217; GO:0009986; GO:0016021; GO:0016486; GO:0035813; GO:1903779 0 0 cd00190; PF01392;PF00057;PF15494;PF00089; Q9Y6E0 CHOYP_LOC100121999.1.4 m.23944 sp STK24_HUMAN 71.429 350 87 5 8 350 28 371 1.30E-161 471 STK24_HUMAN reviewed Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] STK24 MST3 STK3 Homo sapiens (Human) 443 cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; mitotic cell cycle [GO:0000278]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; response to hydrogen peroxide [GO:0042542]; signal transduction [GO:0007165] GO:0000278; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005913; GO:0006468; GO:0006921; GO:0007165; GO:0008631; GO:0016020; GO:0030336; GO:0042542; GO:0046777; GO:0046872; GO:0048679; GO:0070062; GO:0097194; GO:0098641 0 0 0 PF00069; Q9Y6J9 CHOYP_LOC577999.1.1 m.18744 sp TAF6L_HUMAN 41.319 455 235 6 14 442 5 453 1.30E-107 345 TAF6L_HUMAN reviewed TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (PCAF-associated factor 65-alpha) (PAF65-alpha) TAF6L PAF65A Homo sapiens (Human) 622 "chromatin remodeling [GO:0006338]; DNA-templated transcription, initiation [GO:0006352]; histone H3 acetylation [GO:0043966]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of transcription from RNA polymerase II promoter [GO:0006357]" GO:0000118; GO:0003677; GO:0003713; GO:0006338; GO:0006352; GO:0006357; GO:0030914; GO:0043966; GO:0051090; GO:0070062 0 0 0 PF02969;PF07571; Q9YIC0 CHOYP_EEF1A.1.3 m.18897 sp EF1A_ORYLA 86.408 103 14 0 1 103 276 378 1.30E-56 184 EF1A_ORYLA reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; A6QQM4 CHOYP_LOC100368109.1.1 m.18734 sp ZN474_BOVIN 51.62 432 168 11 264 672 38 451 1.31E-134 406 ZN474_BOVIN reviewed Zinc finger protein 474 ZNF474 Bos taurus (Bovine) 454 0 GO:0046872 0 0 0 0 D2GXS7 CHOYP_BRAFLDRAFT_87319.2.5 m.38050 sp TRIM2_AILME 23.529 272 167 8 324 567 449 707 1.31E-08 61.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZUQ0 CHOYP_RIPL1.1.1 m.59984 sp RIPL1_RAT 34.93 355 189 4 11 365 15 327 1.31E-56 194 RIPL1_RAT reviewed RILP-like protein 1 (GAPDH's competitor of SIAH1 protein enhances life) (GOSPEL) (Rab-interacting lysosomal-like protein 1) Rilpl1 Rattus norvegicus (Rat) 406 epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445]; regulation of neuron death [GO:1901214] GO:0003382; GO:0005654; GO:0005813; GO:0005829; GO:0005886; GO:0072372; GO:1901214; GO:1903445 0 0 0 PF09744;PF11461; O01393 CHOYP_LOC100533356.3.6 m.20917 sp UNC9_CAEEL 34.301 379 242 2 12 390 13 384 1.31E-86 271 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O07552 CHOYP_NEMVEDRAFT_V1G242153.3.4 m.17716 sp NHAX_BACSU 24.375 160 105 3 8 151 7 166 1.31E-10 60.1 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O14618 CHOYP_BRAFLDRAFT_247007.1.1 m.15096 sp CCS_HUMAN 45.693 267 121 6 1 245 1 265 1.31E-72 225 CCS_HUMAN reviewed Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone) CCS Homo sapiens (Human) 274 intracellular copper ion transport [GO:0015680]; positive regulation of oxidoreductase activity [GO:0051353]; removal of superoxide radicals [GO:0019430]; response to reactive oxygen species [GO:0000302]; superoxide metabolic process [GO:0006801] GO:0000302; GO:0004784; GO:0005507; GO:0005634; GO:0005737; GO:0005829; GO:0005913; GO:0006801; GO:0008270; GO:0015035; GO:0015680; GO:0016532; GO:0019430; GO:0051353; GO:0098641 0 0 cd00305; PF00403;PF00080; O55071 CHOYP_BRAFLDRAFT_61918.1.2 m.6844 sp CP2BJ_MOUSE 36.876 461 282 5 10 464 5 462 1.31E-109 337 CP2BJ_MOUSE reviewed Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19) Cyp2b19 Mus musculus (Mouse) 492 epoxygenase P450 pathway [GO:0019373] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019373; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; O70277 CHOYP_BRAFLDRAFT_71754.3.3 m.59621 sp TRIM3_RAT 25.984 127 87 3 26 150 622 743 1.31E-09 59.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_87325.9.11 m.32735 sp TRIM3_RAT 27.35 117 79 2 40 151 579 694 1.31E-07 53.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_LOC100374342.9.19 m.33037 sp TRIM3_HUMAN 22.263 274 176 12 306 559 486 742 1.31E-07 58.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P22488 CHOYP_LOC658201.1.1 m.42880 sp IFEA_HELAS 39.316 234 135 2 3 234 273 501 1.31E-46 165 IFEA_HELAS reviewed Non-neuronal cytoplasmic intermediate filament protein (IF) 0 Helix aspersa (Brown garden snail) (Cornu aspersum) 576 0 GO:0005198; GO:0005737; GO:0005882 0 0 0 PF00038; P26591 CHOYP_GLRK.2.3 m.33119 sp GLRK_LYMST 31.298 131 84 2 1 125 497 627 1.31E-16 77.8 GLRK_LYMST reviewed Glutamate receptor 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 917 0 GO:0004970; GO:0005234; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF01094;PF00060;PF10613; P28799 CHOYP_LOC100366380.1.4 m.16838 sp GRN_HUMAN 41.558 308 158 7 30 324 89 387 1.31E-63 214 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P63018 CHOYP_BRAFLDRAFT_114843.1.2 m.14728 sp HSP7C_RAT 88.652 141 16 0 1 141 314 454 1.31E-79 251 HSP7C_RAT reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) Hspa8 Hsc70 Hsc73 Rattus norvegicus (Rat) 646 "aging [GO:0007568]; axo-dendritic transport [GO:0008088]; cellular protein complex disassembly [GO:0043624]; cellular response to cadmium ion [GO:0071276]; cellular response to heat [GO:0034605]; cerebellum development [GO:0021549]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; chaperone-mediated protein folding [GO:0061077]; chaperone mediated protein folding requiring cofactor [GO:0051085]; chaperone-mediated protein transport involved in chaperone-mediated autophagy [GO:0061741]; clathrin coat disassembly [GO:0072318]; estrous cycle [GO:0044849]; forebrain development [GO:0030900]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular protein transmembrane import [GO:0044743]; kidney development [GO:0001822]; mRNA processing [GO:0006397]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of catalytic activity [GO:0043085]; positive regulation of gene expression [GO:0010628]; positive regulation of lysosomal membrane permeability [GO:0097214]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein refolding [GO:1904592]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein refolding [GO:0042026]; regulation of protein complex stability [GO:0061635]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to nickel cation [GO:0010045]; response to odorant [GO:1990834]; response to progesterone [GO:0032570]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; sensory perception of smell [GO:0007608]; skeletal muscle tissue development [GO:0007519]; slow axonal transport [GO:1990832]; transcription, DNA-templated [GO:0006351]" GO:0000082; GO:0000974; GO:0001822; GO:0001916; GO:0001917; GO:0003723; GO:0005102; GO:0005524; GO:0005634; GO:0005681; GO:0005730; GO:0005737; GO:0005764; GO:0005765; GO:0005776; GO:0005829; GO:0005874; GO:0005882; GO:0005886; GO:0006351; GO:0006397; GO:0006606; GO:0007519; GO:0007568; GO:0007608; GO:0008021; GO:0008088; GO:0008134; GO:0008380; GO:0009408; GO:0009986; GO:0010045; GO:0010628; GO:0010667; GO:0014069; GO:0014823; GO:0016887; GO:0019899; GO:0021549; GO:0030424; GO:0030425; GO:0030529; GO:0030900; GO:0031686; GO:0032279; GO:0032355; GO:0032570; GO:0034605; GO:0042026; GO:0042277; GO:0042470; GO:0042493; GO:0042594; GO:0042623; GO:0043005; GO:0043025; GO:0043085; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0043234; GO:0043531; GO:0043624; GO:0044743; GO:0044849; GO:0045121; GO:0045471; GO:0045862; GO:0045892; GO:0046777; GO:0048471; GO:0050766; GO:0051082; GO:0051085; GO:0061077; GO:0061635; GO:0061684; GO:0061741; GO:0070062; GO:0071276; GO:0072318; GO:0097214; GO:1903206; GO:1904592; GO:1904593; GO:1904764; GO:1990124; GO:1990832; GO:1990833; GO:1990834; GO:1990836 0 0 0 PF00012; P82919 CHOYP_LOC100115506.1.2 m.26027 sp RT18A_BOVIN 40.625 128 60 6 48 168 16 134 1.31E-18 82.4 RT18A_BOVIN reviewed "28S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (28S ribosomal protein S18-3, mitochondrial) (MRP-S18-3)" MRPS18A Bos taurus (Bovine) 196 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005763; GO:0022627; GO:0032543; GO:0070124; GO:0070125 0 0 0 PF01084; Q03131 CHOYP_PKS21.1.1 m.35772 sp ERYA1_SACER 26.563 192 125 5 3 181 3203 3391 1.31E-08 62.8 ERYA1_SACER reviewed "6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 (DEBS 1) (EC 2.3.1.94) (6-deoxyerythronolide B synthase I) (Erythronolide synthase) (ORF C)" eryA Saccharopolyspora erythraea (Streptomyces erythraeus) 3491 macrolide biosynthetic process [GO:0033068] GO:0031177; GO:0033068; GO:0047879 "PATHWAY: Antibiotic biosynthesis; erythromycin biosynthesis. {ECO:0000305|PubMed:17328673, ECO:0000305|PubMed:21095573}." 0 0 PF00698;PF16197;PF00109;PF02801;PF08659;PF00550; Q04637 CHOYP_EIF4G1.2.2 m.38530 sp IF4G1_HUMAN 40.767 704 356 15 35 679 724 1425 1.31E-136 441 IF4G1_HUMAN reviewed Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) EIF4G1 EIF4F EIF4G EIF4GI Homo sapiens (Human) 1599 "behavioral fear response [GO:0001662]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of neuron differentiation [GO:0045666]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral process [GO:0016032]" GO:0000184; GO:0000289; GO:0001662; GO:0003743; GO:0005737; GO:0005829; GO:0005913; GO:0006413; GO:0006446; GO:0008135; GO:0008190; GO:0016020; GO:0016032; GO:0016281; GO:0043488; GO:0044822; GO:0045666; GO:0098641 0 0 0 PF02847;PF02854;PF02020; Q06577 CHOYP_LOC101072920.1.1 m.34511 sp HP27_TAMSI 31.707 123 79 2 150 268 93 214 1.31E-09 61.6 HP27_TAMSI reviewed Hibernation-associated plasma protein HP-27 (Hibernator-specific blood complex 27 kDa subunit) 0 Tamias sibiricus (Siberian chipmunk) (Eutamias sibiricus) 215 hibernation [GO:0042750] GO:0005576; GO:0005581; GO:0042750 0 0 0 PF00386;PF01391; Q06805 CHOYP_LOC579946.15.24 m.50012 sp TIE1_BOVIN 39.37 127 53 7 82 190 162 282 1.31E-12 68.9 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q13489 CHOYP_LOC100741028.4.4 m.50208 sp BIRC3_HUMAN 29.477 363 191 7 812 1124 256 603 1.31E-45 177 BIRC3_HUMAN reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 MIHC RNF49 Homo sapiens (Human) 604 cell surface receptor signaling pathway [GO:0007166]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; protein heterooligomerization [GO:0051291]; regulation of apoptotic process [GO:0042981]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; spermatogenesis [GO:0007283]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007166; GO:0007249; GO:0007283; GO:0008270; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0031398; GO:0033209; GO:0034121; GO:0035666; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043234; GO:0045088; GO:0045121; GO:0050727; GO:0051291; GO:0060544; GO:0060546; GO:0070424; GO:1990001; GO:2000116 0 0 0 PF00653;PF00619; Q17QM9 CHOYP_CNRIP1.1.1 m.28504 sp CNRP1_BOVIN 31.056 161 101 3 5 160 8 163 1.31E-18 80.9 CNRP1_BOVIN reviewed CB1 cannabinoid receptor-interacting protein 1 (CRIP-1) CNRIP1 Bos taurus (Bovine) 164 0 GO:0043209 0 0 0 PF15043; Q1EG27 CHOYP_CHS-2.1.1 m.37794 sp MYO3B_MOUSE 35.877 878 483 23 1 845 324 1154 1.31E-135 464 MYO3B_MOUSE reviewed Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) 1305 peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0000146; GO:0001750; GO:0001917; GO:0004674; GO:0005524; GO:0005737; GO:0007601; GO:0016459; GO:0018105; GO:0018107; GO:0032426; GO:0032433; GO:0046777; GO:0050896; GO:0051491 0 0 0 PF00612;PF00063;PF00069; Q29H56 CHOYP_LOC100377311.11.14 m.55074 sp MAB21_DROPS 29.94 167 98 9 202 363 192 344 1.31E-09 64.3 MAB21_DROPS reviewed Protein mab-21 mab-21 GA18400 Drosophila pseudoobscura pseudoobscura (Fruit fly) 365 0 0 0 0 0 PF03281; Q2THW9 CHOYP_PHUM_PHUM098200.1.1 m.18244 sp ZDHC5_CANLF 52.303 304 122 3 3 304 12 294 1.31E-99 321 ZDHC5_CANLF reviewed Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) ZDHHC5 Canis lupus familiaris (Dog) (Canis familiaris) 715 protein palmitoylation [GO:0018345] GO:0005737; GO:0005886; GO:0008270; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q39056 CHOYP_EFTS.2.2 m.66395 sp CNX3_ARATH 59.406 101 41 0 1 101 127 227 1.31E-33 119 CNX3_ARATH reviewed "Cyclic pyranopterin monophosphate synthase accessory protein, mitochondrial (Molybdenum cofactor biosynthesis enzyme CNX3) (Molybdenum cofactor biosynthesis protein C) (Molybdopterin biosynthesis protein CNX3)" CNX3 At1g01290 F6F3.9 Arabidopsis thaliana (Mouse-ear cress) 270 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0005739; GO:0005759; GO:0006777; GO:0009507; GO:0061597 PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. 0 cd01420; PF01967; Q3SZ13 CHOYP_MNF1.1.1 m.27200 sp UQCC2_BOVIN 37.5 120 63 4 2 112 4 120 1.31E-13 65.9 UQCC2_BOVIN reviewed Ubiquinol-cytochrome-c reductase complex assembly factor 2 (Mitochondrial nucleoid factor 1) (Mitochondrial protein M19) UQCC2 MNF1 Bos taurus (Bovine) 136 mitochondrial respiratory chain complex III assembly [GO:0034551]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of mitochondrial translation [GO:0070131]; regulation of insulin secretion [GO:0050796]; regulation of oxidative phosphorylation [GO:0002082]; regulation of skeletal muscle cell differentiation [GO:2001014] GO:0002082; GO:0005739; GO:0005743; GO:0005758; GO:0005759; GO:0034551; GO:0042645; GO:0050796; GO:0070131; GO:1903364; GO:2001014 0 0 0 0 Q4A3R3 CHOYP_DMBT1.19.34 m.39378 sp DMBT1_PIG 53.659 123 53 1 621 739 209 331 1.31E-32 139 DMBT1_PIG reviewed Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) 1204 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0007275; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0035375; GO:0042589 0 0 0 PF00431;PF00530;PF00100; Q50D79 CHOYP_UNC4.1.1 m.43969 sp UNC4_DANRE 45.376 346 144 11 42 347 12 352 1.31E-70 232 UNC4_DANRE reviewed Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) uncx uncx4.1 Danio rerio (Zebrafish) (Brachydanio rerio) 470 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007399; GO:0030154; GO:0043565 0 0 0 PF00046; Q5FVR2 CHOYP_BRAFLDRAFT_244533.1.2 m.40480 sp TYPH_RAT 50.559 358 172 3 6 362 29 382 1.31E-118 354 TYPH_RAT reviewed Thymidine phosphorylase (TP) (EC 2.4.2.4) (TdRPase) Tymp Ecgf1 Rattus norvegicus (Rat) 476 pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; pyrimidine nucleotide metabolic process [GO:0006220] GO:0004645; GO:0005829; GO:0006206; GO:0006213; GO:0006220; GO:0009032; GO:0016154 PATHWAY: Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. 0 0 PF02885;PF00591;PF07831; Q5HZQ9 CHOYP_PCX4.1.1 m.41722 sp PCX4_XENLA 67.742 124 40 0 6 129 1059 1182 1.31E-53 183 PCX4_XENLA reviewed Pecanex-like protein 4 (Pecanex homolog protein 4) pcnx4 pcnxl4 Xenopus laevis (African clawed frog) 1184 0 GO:0016021 0 0 0 PF05041; Q5JTD7 CHOYP_LOC100377880.1.1 m.31085 sp LRC73_HUMAN 30.112 269 166 6 44 308 4 254 1.31E-23 101 LRC73_HUMAN reviewed Leucine-rich repeat-containing protein 73 LRRC73 C6orf154 Homo sapiens (Human) 316 0 0 0 0 0 0 Q5KR61 CHOYP_LOC100727680.1.1 m.66559 sp PIGV_RAT 39.552 268 149 4 10 277 238 492 1.31E-52 181 PIGV_RAT reviewed GPI mannosyltransferase 2 (EC 2.4.1.-) (GPI mannosyltransferase II) (GPI-MT-II) (Phosphatidylinositol-glycan biosynthesis class V protein) (PIG-V) Pigv Rattus norvegicus (Rat) 492 GPI anchor biosynthetic process [GO:0006506] GO:0000030; GO:0004584; GO:0005789; GO:0006506; GO:0016021; GO:0031501 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF04188; Q5R6Y2 CHOYP_CRBN.1.1 m.55512 sp CRBN_PONAB 48.75 400 189 5 52 450 34 418 1.31E-132 392 CRBN_PONAB reviewed Protein cereblon CRBN Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 429 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] GO:0004176; GO:0005634; GO:0005737; GO:0016020; GO:0016567; GO:0031464; GO:0043161; GO:0046872 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96SW2}. 0 0 PF02190;PF03226; Q5UR67 CHOYP_LOC100638431.2.10 m.23012 sp RIBX_MIMIV 43.284 134 65 3 106 228 2 135 1.31E-20 89 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5UR67 CHOYP_LOC100638431.4.10 m.48496 sp RIBX_MIMIV 43.151 146 78 2 127 267 21 166 1.31E-27 108 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5VW36 CHOYP_FOCAD.1.2 m.34123 sp FOCAD_HUMAN 31.111 315 187 7 28 326 351 651 1.31E-36 143 FOCAD_HUMAN reviewed Focadhesin FOCAD KIAA1797 Homo sapiens (Human) 1801 0 GO:0005925; GO:0016021 0 0 0 PF12530;PF11229; Q5ZKA2 CHOYP_RAN.2.3 m.57310 sp SYIM_CHICK 36.364 121 75 2 8 126 808 928 1.31E-13 69.7 SYIM_CHICK reviewed "Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)" IARS2 RCJMB04_12b19 Gallus gallus (Chicken) 1000 isoleucyl-tRNA aminoacylation [GO:0006428] GO:0000049; GO:0002161; GO:0004822; GO:0005524; GO:0005739; GO:0005759; GO:0005829; GO:0006428 0 0 cd07960; PF08264;PF00133; Q5ZLT7 CHOYP_BZW1.1.1 m.44089 sp BZW1_CHICK 56.448 411 171 2 37 445 1 405 1.31E-174 498 BZW1_CHICK reviewed Basic leucine zipper and W2 domain-containing protein 1 BZW1 RCJMB04_4o16 Gallus gallus (Chicken) 418 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006355; GO:0016020; GO:0044822 0 0 0 PF02020; Q6INR1 CHOYP_ISCW_ISCW021601.2.2 m.20304 sp EIF3J_XENLA 45.361 194 86 7 152 327 11 202 1.31E-33 128 EIF3J_XENLA reviewed Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) eif3j eif3s1 Xenopus laevis (African clawed frog) 255 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446] GO:0001731; GO:0003743; GO:0005852; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF08597; Q6P7W0 CHOYP_LOC100559910.2.2 m.57534 sp SENP6_MOUSE 32.523 329 160 11 162 432 417 741 1.31E-35 144 SENP6_MOUSE reviewed Sentrin-specific protease 6 (EC 3.4.22.68) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) Senp6 Kiaa0797 Susp1 Mus musculus (Mouse) 1132 protein desumoylation [GO:0016926]; protein modification by small protein removal [GO:0070646]; protein sumoylation [GO:0016925]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169] GO:0005654; GO:0005737; GO:0016925; GO:0016926; GO:0016929; GO:0070646; GO:0090169; GO:0090234 PATHWAY: Protein modification; protein sumoylation. 0 0 PF02902; Q6R7F6 CHOYP_Y071.1.1 m.29248 sp Y072_OSHVF 100 188 0 0 1 188 1 188 1.31E-135 379 Y072_OSHVF reviewed Uncharacterized protein ORF72 ORF72 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 188 0 GO:0016021; GO:0033644 0 0 0 0 Q6TLF6 CHOYP_LOC100693050.1.1 m.3039 sp RGN_DANRE 41.311 305 164 6 1 303 4 295 1.31E-72 228 RGN_DANRE reviewed Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) rgn zgc:92078 Danio rerio (Zebrafish) (Brachydanio rerio) 295 cellular calcium ion homeostasis [GO:0006874]; L-ascorbic acid biosynthetic process [GO:0019853]; positive regulation of ATPase activity [GO:0032781]; regulation of calcium-mediated signaling [GO:0050848] GO:0004341; GO:0005509; GO:0005634; GO:0005737; GO:0006874; GO:0008270; GO:0019853; GO:0030234; GO:0032781; GO:0050848 PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. 0 0 PF08450; Q70PU1 CHOYP_PGLYRP1.1.1 m.2173 sp PGSC2_DROSI 39.665 179 107 1 9 187 5 182 1.31E-44 149 PGSC2_DROSI reviewed Peptidoglycan-recognition protein SC2 (EC 3.5.1.28) PGRP-SC2 GD10595 Drosophila simulans (Fruit fly) 184 innate immune response [GO:0045087]; peptidoglycan catabolic process [GO:0009253] GO:0005576; GO:0008270; GO:0008745; GO:0009253; GO:0045087 0 0 cd06583; PF01510; Q7ZWG6 CHOYP_SLC46A3.1.1 m.5265 sp PCFT_DANRE 27.682 289 193 8 63 347 85 361 1.31E-21 99 PCFT_DANRE reviewed Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) 481 transmembrane transport [GO:0055085] GO:0005542; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q7ZXW9 CHOYP_BRAFLDRAFT_268591.1.1 m.59743 sp TISDA_XENLA 67.273 110 34 2 19 127 127 235 1.31E-45 160 TISDA_XENLA reviewed "Zinc finger protein 36, C3H1 type-like 2-A (CCCH zinc finger protein 3) (XC3H-3)" zfp36l2-A Xenopus laevis (African clawed frog) 363 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; MAPK cascade [GO:0000165]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of stem cell differentiation [GO:2000737]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; pronephros development [GO:0048793]; regulation of mRNA stability [GO:0043488]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]" GO:0000165; GO:0000288; GO:0003677; GO:0005634; GO:0005737; GO:0006402; GO:0030097; GO:0031086; GO:0035019; GO:0035925; GO:0043488; GO:0044344; GO:0045599; GO:0046872; GO:0048103; GO:0048793; GO:0060216; GO:0061158; GO:0070371; GO:0071356; GO:0071364; GO:0071385; GO:0071560; GO:0097011; GO:1900153; GO:1904628; GO:2000737 0 0 0 PF04553;PF00642; Q89YT0 CHOYP_TRIADDRAFT_21078.1.2 m.14567 sp END4_BACTN 52.14 257 119 2 1 257 24 276 1.31E-99 295 END4_BACTN reviewed Probable endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV) nfo BT_4651 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) 277 base-excision repair [GO:0006284] GO:0003677; GO:0003906; GO:0006284; GO:0008081; GO:0008270; GO:0008833 0 0 0 PF01261; Q8C341 CHOYP_C8H1ORF9.1.1 m.36067 sp SUCO_MOUSE 37.813 320 161 10 218 514 267 571 1.31E-49 196 SUCO_MOUSE reviewed SUN domain-containing ossification factor (Membrane protein CH1) (Protein osteopotentia) (SUN-like protein 1) Suco Opt Mus musculus (Mouse) 1250 multicellular organism development [GO:0007275]; ossification [GO:0001503]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of bone remodeling [GO:0046850] GO:0001503; GO:0005791; GO:0007275; GO:0016020; GO:0016021; GO:0030867; GO:0032967; GO:0045669; GO:0046850 0 0 0 PF07738; Q8ISN9 CHOYP_RS25.6.11 m.21859 sp RS25_BRABE 81.25 112 20 1 1 111 1 112 1.31E-43 141 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8K1T0 CHOYP_HEPS.1.1 m.29723 sp TMPS3_MOUSE 41.935 248 138 4 72 316 203 447 1.31E-60 203 TMPS3_MOUSE reviewed Transmembrane protease serine 3 (EC 3.4.21.-) Tmprss3 Mus musculus (Mouse) 453 cellular sodium ion homeostasis [GO:0006883]; sensory perception of sound [GO:0007605] GO:0004252; GO:0005044; GO:0005783; GO:0005789; GO:0006883; GO:0007605; GO:0016021; GO:0017080; GO:0043025 0 0 cd00190; PF00057;PF15494;PF00089; Q8N6D5 CHOYP_LOC587475.1.3 m.32164 sp ANR29_HUMAN 35.429 175 112 1 1 175 95 268 1.31E-32 120 ANR29_HUMAN reviewed Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) 301 0 0 0 0 0 PF00023;PF12796; Q8NBJ4 CHOYP_BRAFLDRAFT_88543.1.2 m.54473 sp GOLM1_HUMAN 26.619 139 95 2 48 182 3 138 1.31E-07 57.4 GOLM1_HUMAN reviewed Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326 Homo sapiens (Human) 401 nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216] GO:0005615; GO:0005794; GO:0005887; GO:0006997; GO:0019216; GO:0070062 0 0 0 0 Q8R151 CHOYP_LOC663631.1.2 m.31835 sp ZNFX1_MOUSE 36.474 329 181 8 366 679 1335 1650 1.31E-50 199 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8TDX7 CHOYP_LOC100371148.1.1 m.47147 sp NEK7_HUMAN 82.963 270 46 0 26 295 28 297 1.31E-175 494 NEK7_HUMAN reviewed Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) NEK7 Homo sapiens (Human) 302 cytokinesis [GO:0000910]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle [GO:0007346]; spindle assembly [GO:0051225] GO:0000910; GO:0000922; GO:0004674; GO:0005524; GO:0005654; GO:0005737; GO:0005815; GO:0005874; GO:0006468; GO:0007346; GO:0032212; GO:0046872; GO:0051225; GO:0051973; GO:1904355 0 0 0 PF00069; Q96RU3 CHOYP_LOC558990.1.1 m.23341 sp FNBP1_HUMAN 54.237 59 27 0 58 116 550 608 1.31E-19 86.3 FNBP1_HUMAN reviewed Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) FNBP1 FBP17 KIAA0554 Homo sapiens (Human) 617 endocytosis [GO:0006897]; vesicle-mediated transport [GO:0016192] GO:0005086; GO:0005764; GO:0005802; GO:0005856; GO:0005886; GO:0005905; GO:0005938; GO:0006897; GO:0008289; GO:0016023; GO:0016192; GO:0042802 0 0 0 PF00611;PF14604; Q96RW7 CHOYP_CNTN6.2.2 m.40740 sp HMCN1_HUMAN 24.261 643 371 28 3 590 3714 4295 1.31E-18 95.9 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99572 CHOYP_BRAFLDRAFT_67258.11.18 m.46363 sp P2RX7_HUMAN 32 125 77 2 33 152 470 591 1.31E-15 76.3 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; Q9BXM7 CHOYP_SACS.5.17 m.34877 sp PINK1_HUMAN 51.064 141 65 2 1 137 362 502 1.31E-39 142 PINK1_HUMAN reviewed "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" PINK1 Homo sapiens (Human) 581 "activation of protein kinase B activity [GO:0032148]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; establishment of protein localization to mitochondrion [GO:0072655]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000422]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of JNK cascade [GO:0046329]; negative regulation of macroautophagy [GO:0016242]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1903147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced cell death [GO:1903202]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of free ubiquitin chain polymerization [GO:1904544]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of peptidase activity [GO:0010952]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of translation [GO:0045727]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of mitophagy [GO:1903146]; regulation of oxidative phosphorylation [GO:0002082]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein complex assembly [GO:0043254]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of synaptic vesicle transport [GO:1902803]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979]; response to stress [GO:0006950]; TORC2 signaling [GO:0038203]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0000287; GO:0000422; GO:0000785; GO:0001934; GO:0002020; GO:0002082; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005758; GO:0005829; GO:0005856; GO:0006468; GO:0006511; GO:0006950; GO:0006979; GO:0007005; GO:0010310; GO:0010629; GO:0010821; GO:0010857; GO:0010952; GO:0016020; GO:0016236; GO:0016239; GO:0016242; GO:0016301; GO:0016310; GO:0016504; GO:0016567; GO:0018105; GO:0022904; GO:0030424; GO:0031307; GO:0031396; GO:0031398; GO:0031625; GO:0032148; GO:0032226; GO:0033138; GO:0033603; GO:0034599; GO:0035307; GO:0035556; GO:0036289; GO:0038203; GO:0043123; GO:0043254; GO:0043422; GO:0043524; GO:0044297; GO:0045727; GO:0046329; GO:0048471; GO:0050821; GO:0051091; GO:0051443; GO:0051881; GO:0051897; GO:0055131; GO:0061136; GO:0071456; GO:0072655; GO:0072656; GO:0090141; GO:0090200; GO:0090258; GO:0097237; GO:0097413; GO:0097449; GO:0098779; GO:1902803; GO:1902902; GO:1902958; GO:1903146; GO:1903147; GO:1903202; GO:1903204; GO:1903214; GO:1903298; GO:1903384; GO:1903751; GO:1903852; GO:1903955; GO:1904544; GO:2000377; GO:2000378; GO:2001171 0 0 0 PF00069; Q9CQY2 CHOYP_ISCW_ISCW002750.1.3 m.6256 sp RAM_MOUSE 37.079 89 47 1 40 119 4 92 1.31E-08 54.3 RAM_MOUSE reviewed RNMT-activating mini protein (RAM) (Protein FAM103A1) Fam103a1 Mus musculus (Mouse) 119 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031] GO:0003723; GO:0005634; GO:0005845; GO:0006370; GO:0032259; GO:0036031; GO:0044822 0 0 0 PF15320; Q9CR41 CHOYP_BRAFLDRAFT_119906.1.1 m.45320 sp HYPK_MOUSE 57.143 119 45 1 17 129 11 129 1.31E-37 127 HYPK_MOUSE reviewed Huntingtin-interacting protein K (Huntingtin yeast partner K) Hypk Mus musculus (Mouse) 129 0 GO:0005654; GO:0005737; GO:0015630 0 0 0 0 Q9CW42 CHOYP_BRAFLDRAFT_278045.1.1 m.11086 sp MARC1_MOUSE 36.77 291 165 6 34 315 57 337 1.31E-62 204 MARC1_MOUSE reviewed Mitochondrial amidoxime-reducing component 1 (mARC1) (EC 1.-.-.-) (Molybdenum cofactor sulfurase C-terminal domain-containing protein 1) (MOSC domain-containing protein 1) (Moco sulfurase C-terminal domain-containing protein 1) Marc1 Mosc1 Mus musculus (Mouse) 340 nitrate metabolic process [GO:0042126]; oxidation-reduction process [GO:0055114] GO:0005739; GO:0005741; GO:0005743; GO:0008940; GO:0016021; GO:0030151; GO:0030170; GO:0042126; GO:0043546; GO:0055114 0 0 0 PF03473;PF03476; Q9D489 CHOYP_LOC100667675.1.1 m.12810 sp SOLH2_MOUSE 45.556 90 39 1 318 407 205 284 1.31E-15 83.2 SOLH2_MOUSE reviewed Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 Sohlh2 Tohlh2 Mus musculus (Mouse) 467 oocyte differentiation [GO:0009994]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; primary ovarian follicle growth [GO:0001545]; regulation of gene expression [GO:0010468]; spermatogenesis [GO:0007283] GO:0000977; GO:0001046; GO:0001228; GO:0001545; GO:0005634; GO:0007283; GO:0009994; GO:0010468; GO:0045944 0 0 0 PF00010; Q9ESN6 CHOYP_LOC100374741.72.83 m.60196 sp TRIM2_MOUSE 27.149 221 135 8 347 555 536 742 1.31E-11 70.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H8W5 CHOYP_BRAFLDRAFT_85511.2.23 m.13731 sp TRI45_HUMAN 25.926 270 170 9 11 260 135 394 1.31E-10 67.4 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9H999 CHOYP_PANK3.1.1 m.9488 sp PANK3_HUMAN 66.205 361 119 1 32 389 4 364 1.31E-176 499 PANK3_HUMAN reviewed Pantothenate kinase 3 (hPanK3) (EC 2.7.1.33) (Pantothenic acid kinase 3) PANK3 Homo sapiens (Human) 370 coenzyme A biosynthetic process [GO:0015937] GO:0004594; GO:0005524; GO:0005737; GO:0015937 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. 0 0 PF03630; Q9JI92 CHOYP_SDCB1.1.1 m.43802 sp SDCB1_RAT 59.836 122 42 2 1 116 70 190 1.31E-44 150 SDCB1_RAT reviewed Syntenin-1 (Syndecan-binding protein 1) Sdcbp Rattus norvegicus (Rat) 300 actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor internalization [GO:0002091]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346] GO:0001948; GO:0002091; GO:0005137; GO:0005634; GO:0005789; GO:0005829; GO:0005856; GO:0005886; GO:0005895; GO:0005925; GO:0007265; GO:0007268; GO:0007346; GO:0008022; GO:0008284; GO:0010718; GO:0010862; GO:0019838; GO:0030036; GO:0030307; GO:0030335; GO:0030511; GO:0032435; GO:0042043; GO:0042470; GO:0042803; GO:0045121; GO:0045545; GO:0046875; GO:0046982; GO:0050839; GO:0070062; GO:0072562; GO:1903543; GO:1903553 0 0 0 PF00595; Q9JJL8 CHOYP_LOC100376222.1.1 m.34588 sp SYSM_MOUSE 46.847 333 171 4 92 420 155 485 1.31E-104 323 SYSM_MOUSE reviewed "Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" Sars2 Sarsm Mus musculus (Mouse) 518 selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; seryl-tRNA aminoacylation [GO:0006434] GO:0004828; GO:0005524; GO:0005737; GO:0005739; GO:0005759; GO:0006434; GO:0044822; GO:0097056 PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. 0 cd00770; PF02403;PF00587; Q9NLA3 CHOYP_MP62.2.2 m.66634 sp ANO39_PATPE 39.316 117 65 1 78 188 2 118 1.31E-18 88.2 ANO39_PATPE reviewed Nucleoplasmin-like protein ANO39 (39 kDa oocyte-expressed nucleolar protein) (Nucleic acid-associated protein 36) (Nucleic acid-binding nuclear protein) (NAAP) (NAAP1) (NAAP2) 0 Patiria pectinifera (Starfish) (Asterina pectinifera) 346 mitotic nuclear division [GO:0007067]; oocyte maturation [GO:0001556] GO:0001556; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007067 0 0 0 PF16276;PF03066; Q9NPB1 CHOYP_NT5M.1.1 m.6188 sp NT5M_HUMAN 49.738 191 93 3 47 236 38 226 1.31E-63 201 NT5M_HUMAN reviewed "5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)" NT5M DNT2 Homo sapiens (Human) 228 DNA replication [GO:0006260]; dUMP catabolic process [GO:0046079]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; pyrimidine nucleoside catabolic process [GO:0046135] GO:0000166; GO:0005739; GO:0005759; GO:0006260; GO:0008252; GO:0008253; GO:0009223; GO:0046079; GO:0046135; GO:0046872 0 0 0 PF06941; Q9UI36 CHOYP_PHUM_PHUM350510.1.1 m.44180 sp DACH1_HUMAN 76.923 130 29 1 51 180 174 302 1.31E-60 216 DACH1_HUMAN reviewed Dachshund homolog 1 (Dach1) DACH1 DACH Homo sapiens (Human) 760 "cell proliferation [GO:0008283]; development of primary female sexual characteristics [GO:0046545]; multicellular organism development [GO:0007275]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by competitive promoter binding [GO:0010944]; regulation of nuclear cell cycle DNA replication [GO:0033262]; respiratory gaseous exchange [GO:0007585]; suckling behavior [GO:0001967]" GO:0001075; GO:0001078; GO:0001967; GO:0003677; GO:0005634; GO:0005667; GO:0005737; GO:0007275; GO:0007585; GO:0008283; GO:0010944; GO:0030336; GO:0033262; GO:0045892; GO:0046545; GO:0048147; GO:0060244; GO:2000279 0 0 0 PF02437; Q9VPQ6 CHOYP_LOC100577801.1.1 m.7007 sp USH_DROME 28.346 254 130 6 651 895 724 934 1.31E-22 108 USH_DROME reviewed Zinc finger protein ush (Protein U-shaped) ush CG2762 Drosophila melanogaster (Fruit fly) 1191 "amnioserosa maintenance [GO:0046665]; chaeta development [GO:0022416]; compound eye development [GO:0048749]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell fate determination [GO:0007393]; ectoderm development [GO:0007398]; germ-band shortening [GO:0007390]; head involution [GO:0008258]; heart development [GO:0007507]; hemopoiesis [GO:0030097]; larval lymph gland hemopoiesis [GO:0035167]; lymph gland development [GO:0048542]; negative regulation of cell fate specification [GO:0009996]; negative regulation of crystal cell differentiation [GO:0042690]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pigment metabolic process [GO:0042440]; regulation of antimicrobial peptide biosynthetic process [GO:0002805]; regulation of transcription, DNA-templated [GO:0006355]; terminal region determination [GO:0007362]; torso signaling pathway [GO:0008293]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001078; GO:0001102; GO:0002805; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007362; GO:0007390; GO:0007391; GO:0007393; GO:0007398; GO:0007507; GO:0008134; GO:0008258; GO:0008293; GO:0009996; GO:0022416; GO:0030097; GO:0035167; GO:0042440; GO:0042690; GO:0043433; GO:0046665; GO:0046872; GO:0048542; GO:0048749 0 0 0 0 Q9Y603 CHOYP_ETV6.1.1 m.22834 sp ETV7_HUMAN 33.333 315 162 8 60 372 43 311 1.31E-47 171 ETV7_HUMAN reviewed Transcription factor ETV7 (ETS translocation variant 7) (ETS-related protein Tel2) (Tel-related Ets factor) (Transcription factor Tel-2) ETV7 TEL2 TELB TREF Homo sapiens (Human) 341 cell differentiation [GO:0030154]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; organ morphogenesis [GO:0009887]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0000977; GO:0001227; GO:0005634; GO:0005654; GO:0006366; GO:0009887; GO:0030154 0 0 0 PF00178;PF02198; Q9ZR02 CHOYP_BRAFLDRAFT_117737.1.1 m.4255 sp CML6_ARATH 29.63 135 69 4 100 208 1 135 1.31E-09 58.5 CML6_ARATH reviewed Calmodulin-like protein 6 CML6 At4g03290 F4C21.22 Arabidopsis thaliana (Mouse-ear cress) 154 response to cold [GO:0009409] GO:0005509; GO:0005634; GO:0005737; GO:0009409 0 0 0 PF13499; B1WB06 CHOYP_LOC100375376.1.2 m.15615 sp MET24_XENTR 26.471 238 141 9 324 530 118 352 1.32E-12 72.8 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; B7U179 CHOYP_NEMVEDRAFT_V1G221088.1.1 m.66380 sp ABAP1_ARATH 26.126 111 82 0 26 136 559 669 1.32E-10 64.7 ABAP1_ARATH reviewed ARMADILLO BTB ARABIDOPSIS PROTEIN 1 (ABAP1) ABAP1 At5g13060 T19L5.20 Arabidopsis thaliana (Mouse-ear cress) 737 DNA-dependent DNA replication [GO:0006261]; negative regulation of cell proliferation [GO:0008285]; negative regulation of DNA-dependent DNA replication [GO:2000104]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127] GO:0005634; GO:0005737; GO:0006261; GO:0008285; GO:0016567; GO:0031261; GO:0042127; GO:2000104 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00514;PF00651; D8VNS7 CHOYP_BRAFLDRAFT_252169.6.6 m.57784 sp FCNV1_CERRY 49.462 186 83 5 155 339 129 304 1.32E-48 171 FCNV1_CERRY reviewed Ryncolin-1 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; D8VNT0 CHOYP_BRAFLDRAFT_86061.12.13 m.60014 sp FCNV4_CERRY 45.755 212 110 3 90 299 128 336 1.32E-58 194 FCNV4_CERRY reviewed Ryncolin-4 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; F1MJR8 CHOYP_TEX14.1.1 m.45776 sp TEX14_BOVIN 34.455 505 302 12 7 495 13 504 1.32E-77 283 TEX14_BOVIN reviewed Inactive serine/threonine-protein kinase TEX14 (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein) TEX14 Bos taurus (Bovine) 1493 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; intercellular bridge organization [GO:0043063]; male meiosis [GO:0007140]; mitotic sister chromatid separation [GO:0051306]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of cytokinesis [GO:0032466]; negative regulation of protein binding [GO:0032091] GO:0000776; GO:0000777; GO:0004672; GO:0005524; GO:0005623; GO:0005737; GO:0007094; GO:0007140; GO:0008608; GO:0030496; GO:0032091; GO:0032466; GO:0043063; GO:0045171; GO:0051301; GO:0051306; GO:0070062 0 0 0 PF12796;PF07714; O15990 CHOYP_KARG.6.11 m.15509 sp KARG_LIOJA 60.369 217 82 2 1 216 81 294 1.32E-92 278 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O43301 CHOYP_BRAFLDRAFT_208436.25.32 m.60144 sp HS12A_HUMAN 34.026 626 337 17 9 573 56 666 1.32E-102 333 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O43390 CHOYP_ACSS3.1.1 m.64147 sp HNRPR_HUMAN 53.226 62 21 3 62 116 572 632 1.32E-09 57.4 HNRPR_HUMAN reviewed Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR HNRPR Homo sapiens (Human) 633 "circadian rhythm [GO:0007623]; gene expression [GO:0010467]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of catalytic activity [GO:0043086]; positive regulation of mRNA catabolic process [GO:0061014]" GO:0000166; GO:0000398; GO:0003723; GO:0003730; GO:0005654; GO:0005681; GO:0005783; GO:0006397; GO:0007623; GO:0010467; GO:0030425; GO:0030426; GO:0030529; GO:0043086; GO:0043679; GO:0044822; GO:0061014; GO:0061157; GO:0071013 0 0 0 PF00076; O70277 CHOYP_LOC100374342.1.19 m.384 sp TRIM3_RAT 27.027 222 143 8 329 542 534 744 1.32E-10 67.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O73853 CHOYP_CP17A.2.2 m.62161 sp CP17A_ICTPU 33.267 502 316 8 9 499 1 494 1.32E-94 299 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; O74503 CHOYP_LOC654949.1.1 m.9313 sp UAF30_SCHPO 28.39 236 122 4 31 266 8 196 1.32E-20 90.5 UAF30_SCHPO reviewed Upstream activation factor subunit spp27 (Upstream activation factor 27 KDa subunit) (p27) (Upstream activation factor 30 KDa subunit) (p30) (Upstream activation factor subunit uaf30) spp27 uaf30 SPCC285.17 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 233 "positive regulation of transcription from RNA polymerase I promoter [GO:0045943]; transcription, DNA-templated [GO:0006351]" GO:0000500; GO:0003677; GO:0005634; GO:0005829; GO:0006351; GO:0045943 0 0 0 PF08766;PF02201; O75340 CHOYP_BRAFLDRAFT_280861.2.2 m.30165 sp PDCD6_HUMAN 71.257 167 48 0 22 188 24 190 1.32E-89 263 PDCD6_HUMAN reviewed Programmed cell death protein 6 (Apoptosis-linked gene 2 protein) (Probable calcium-binding protein ALG-2) PDCD6 ALG2 Homo sapiens (Human) 191 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cellular response to heat [GO:0034605]; intracellular protein transport [GO:0006886]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324] GO:0001525; GO:0001938; GO:0004198; GO:0005509; GO:0005634; GO:0005737; GO:0005768; GO:0005783; GO:0005789; GO:0006886; GO:0006919; GO:0010595; GO:0030948; GO:0031410; GO:0031965; GO:0032007; GO:0034605; GO:0036324; GO:0042802; GO:0043280; GO:0043495; GO:0045766; GO:0046983; GO:0048306; GO:0051592; GO:0051898; GO:0060090; GO:0070062; GO:0070971; GO:0097190 0 0 0 PF13202;PF13499; O97788 CHOYP_DGRI_GH15313.1.1 m.5763 sp FABP4_PIG 33.333 129 86 0 3 131 4 132 1.32E-18 79.3 FABP4_PIG reviewed "Fatty acid-binding protein, adipocyte (AP2) (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)" FABP4 Sus scrofa (Pig) 132 regulation of inflammatory response [GO:0050727] GO:0005215; GO:0005504; GO:0005634; GO:0005737; GO:0050727 0 0 0 PF00061; P02553 CHOYP_LOC754102.1.1 m.57578 sp TBA_LYTPI 97.842 139 3 0 1 139 23 161 1.32E-98 283 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P04323 CHOYP_LOC100695950.3.6 m.17035 sp POL3_DROME 30.546 861 515 25 176 1005 163 971 1.32E-100 349 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P06731 CHOYP_CEACAM1.3.3 m.66411 sp CEAM5_HUMAN 24.907 269 166 10 113 378 274 509 1.32E-11 70.5 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; P08761 CHOYP_TRIADDRAFT_6339.1.1 m.7045 sp MSRA_DROME 42.857 126 63 3 38 157 83 205 1.32E-26 103 MSRA_DROME reviewed Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Ecdysone-induced protein 28/29 kDa) (Methionine-S-sulfoxide reductase) (Peptide-methionine (S)-S-oxide reductase) Eip71CD Eip28/29 MsrA CG7266 Drosophila melanogaster (Fruit fly) 246 autophagic cell death [GO:0048102]; cellular response to oxidative stress [GO:0034599]; determination of adult lifespan [GO:0008340]; neuron projection morphogenesis [GO:0048812]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]; salivary gland cell autophagic cell death [GO:0035071]; sulfur amino acid metabolic process [GO:0000096] GO:0000096; GO:0006979; GO:0008113; GO:0008340; GO:0030091; GO:0034599; GO:0035071; GO:0048102; GO:0048812 0 0 0 PF01625; P14099 CHOYP_LOC101070163.1.1 m.41119 sp PDE2A_BOVIN 41.429 70 33 1 41 102 177 246 1.32E-07 51.2 PDE2A_BOVIN reviewed "cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)" PDE2A Bos taurus (Bovine) 921 "cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to drug [GO:0035690]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; GMP catabolic process [GO:0046038]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of protein import into nucleus, translocation [GO:0033159]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]; protein targeting to mitochondrion [GO:0006626]; regulation of cAMP metabolic process [GO:0030814]; signal transduction [GO:0007165]" GO:0000122; GO:0004112; GO:0004118; GO:0005634; GO:0005737; GO:0005759; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006198; GO:0006626; GO:0007165; GO:0008144; GO:0019933; GO:0019934; GO:0030553; GO:0030814; GO:0030818; GO:0033159; GO:0035690; GO:0036006; GO:0042734; GO:0043116; GO:0043117; GO:0046038; GO:0046069; GO:0046872; GO:0048471; GO:0050729; GO:0061028; GO:0071260; GO:0071321; GO:0097011 0 0 0 PF01590;PF13185;PF00233; P16157 CHOYP_LOC753709.11.44 m.23554 sp ANK1_HUMAN 29.859 710 438 28 9 687 70 750 1.32E-55 209 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_168010.10.45 m.33083 sp ANK1_HUMAN 33.333 357 221 3 100 456 206 545 1.32E-45 173 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_396410.1.1 m.64647 sp ANK1_HUMAN 33.974 312 189 4 95 391 210 519 1.32E-41 160 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18142 CHOYP_LOC100372879.1.3 m.18886 sp D2_DICDI 29.435 513 333 13 22 518 29 528 1.32E-59 209 D2_DICDI reviewed cAMP-regulated D2 protein D2 DDB_G0283085 Dictyostelium discoideum (Slime mold) 535 0 GO:0033118; GO:0052689 0 0 0 PF00135; P32251 CHOYP_OPN4.1.1 m.49529 sp ADRA2_CARAU 23.855 415 248 11 137 507 7 397 1.32E-18 92 ADRA2_CARAU reviewed Alpha-2 adrenergic receptor (Alpha-2 adrenoreceptor) (Alpha-2 adrenoceptor) 0 Carassius auratus (Goldfish) 436 0 GO:0004935; GO:0005886; GO:0016021 0 0 0 PF00001; P34473 CHOYP_LOC100893631.1.1 m.17583 sp YMH6_CAEEL 31.818 132 86 2 149 278 51 180 1.32E-13 71.2 YMH6_CAEEL reviewed Uncharacterized protein F58A4.6 F58A4.6 Caenorhabditis elegans 201 0 0 0 0 0 PF16065; P36609 CHOYP_SMP_158990.1.1 m.28205 sp NCS2_CAEEL 59.043 188 77 0 1 188 1 188 1.32E-80 240 NCS2_CAEEL reviewed Neuronal calcium sensor 2 (NCS-2) ncs-2 F10G8.5 Caenorhabditis elegans 190 0 GO:0005509 0 0 0 PF00036;PF13499; P42577 CHOYP_LOC100533455.8.9 m.49947 sp FRIS_LYMST 81.437 167 31 0 1 167 1 167 1.32E-100 290 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P46197 CHOYP_ANPRB.1.2 m.25104 sp ANPRB_BOVIN 47.321 560 274 8 2 547 486 1038 1.32E-164 498 ANPRB_BOVIN reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) NPR2 Bos taurus (Bovine) 1047 cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007168; GO:0008074; GO:0016941; GO:0035556; GO:0042802 0 0 0 PF01094;PF00211;PF07714; P46436 CHOYP_GST1.1.2 m.29103 sp GST1_ASCSU 44.878 205 109 2 1 202 1 204 1.32E-51 168 GST1_ASCSU reviewed Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma) GST1 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 206 oxidation-reduction process [GO:0055114] GO:0004364; GO:0004602; GO:0005737; GO:0005903; GO:0055114 0 0 0 PF14497;PF02798; P52756 CHOYP_RBM10.1.2 m.55986 sp RBM5_HUMAN 34.082 267 128 8 1 228 251 508 1.32E-34 134 RBM5_HUMAN reviewed RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9) RBM5 H37 LUCA15 Homo sapiens (Human) 815 "apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; spliceosomal complex assembly [GO:0000245]" GO:0000166; GO:0000245; GO:0000381; GO:0000398; GO:0003677; GO:0003723; GO:0003729; GO:0005634; GO:0005654; GO:0005681; GO:0006396; GO:0006915; GO:0008270; GO:0008285; GO:0043065; GO:0044822 0 0 0 PF01585;PF00076;PF00641; P97499 CHOYP_LOC584519.1.1 m.10339 sp TEP1_MOUSE 38.583 381 184 4 71 445 249 585 1.32E-83 286 TEP1_MOUSE reviewed Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) Tep1 Tp1 Mus musculus (Mouse) 2629 telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000781; GO:0002039; GO:0003720; GO:0003723; GO:0005524; GO:0005697; GO:0005737; GO:0016363; GO:0019899; GO:0070034 0 0 0 PF13271;PF05386;PF05731;PF00400; Q02357 CHOYP_TVAG_451090.7.13 m.54151 sp ANK1_MOUSE 39.13 207 126 0 3 209 184 390 1.32E-37 141 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q03188 CHOYP_BRAFLDRAFT_131249.1.1 m.13049 sp CENPC_HUMAN 28.696 230 148 7 1336 1563 727 942 1.32E-17 93.2 CENPC_HUMAN reviewed Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) CENPC CENPC1 ICEN7 Homo sapiens (Human) 943 cell division [GO:0051301]; CENP-A containing nucleosome assembly [GO:0034080]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; sister chromatid cohesion [GO:0007062] GO:0000278; GO:0000776; GO:0000777; GO:0000780; GO:0003677; GO:0005634; GO:0005654; GO:0005721; GO:0005737; GO:0005829; GO:0007059; GO:0007062; GO:0007067; GO:0019237; GO:0034080; GO:0051301; GO:0051382 0 0 0 PF11699;PF15620;PF15622; Q05895 CHOYP_EF1B.3.7 m.35084 sp TSP3_MOUSE 66.234 77 26 0 1 77 576 652 1.32E-23 97.8 TSP3_MOUSE reviewed Thrombospondin-3 Thbs3 Tsp3 Mus musculus (Mouse) 956 bone trabecula formation [GO:0060346]; cell adhesion [GO:0007155]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931] GO:0003417; GO:0005509; GO:0005576; GO:0007155; GO:0008201; GO:0043931; GO:0048471; GO:0060346 0 0 0 PF11598;PF07645;PF02412;PF05735; Q08C99 CHOYP_LOC100887903.1.2 m.582 sp VRTN_DANRE 27.542 236 150 7 884 1116 29 246 1.32E-12 76.3 VRTN_DANRE reviewed Vertnin vrtn si:ch211-146n9.1 si:dkey-1h6.4 zgc:153349 Danio rerio (Zebrafish) (Brachydanio rerio) 677 0 0 0 0 0 0 Q08DF4 CHOYP_DYN1.1.3 m.2328 sp DYN1_BOVIN 53.289 304 106 10 1 298 564 837 1.32E-84 274 DYN1_BOVIN reviewed Dynamin-1 (EC 3.6.5.5) DNM1 Bos taurus (Bovine) 856 "adult locomotory behavior [GO:0008344]; clathrin-mediated endocytosis [GO:0072583]; endosome organization [GO:0007032]; negative regulation of exocytosis [GO:0045920]; protein tetramerization [GO:0051262]; sensory perception of sound [GO:0007605]; synaptic transmission, GABAergic [GO:0051932]; toxin transport [GO:1901998]" GO:0001917; GO:0003924; GO:0005525; GO:0005874; GO:0007032; GO:0007605; GO:0008022; GO:0008344; GO:0030117; GO:0042584; GO:0043209; GO:0044822; GO:0045920; GO:0051262; GO:0051932; GO:0070062; GO:0072583; GO:1901998 0 0 0 PF01031;PF00350;PF02212;PF00169; Q0IHQ9 CHOYP_LOC100566705.1.1 m.6626 sp PXYP1_XENTR 23.148 432 276 17 80 466 71 491 1.32E-09 63.9 PXYP1_XENTR reviewed 2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) pxylp1 acpl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 501 chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909] GO:0000139; GO:0003993; GO:0005794; GO:0006024; GO:0010909; GO:0016021; GO:0016791; GO:0050650 0 0 cd07061; PF00328; Q14314 CHOYP_FGL2.3.9 m.31937 sp FGL2_HUMAN 41.35 237 120 10 169 401 171 392 1.32E-40 153 FGL2_HUMAN reviewed Fibroleukin (Fibrinogen-like protein 2) (pT49) FGL2 Homo sapiens (Human) 439 0 GO:0005577; GO:0008233; GO:0070062 0 0 0 PF00147; Q24K15 CHOYP_ANGP4.4.7 m.33574 sp ANGP4_BOVIN 30.556 432 265 9 7 407 68 495 1.32E-54 191 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q2YDE7 CHOYP_SMP_054450.1.1 m.12176 sp ARCH_BOVIN 72.143 140 37 2 11 150 30 167 1.32E-68 207 ARCH_BOVIN reviewed Protein archease (Protein ZBTB8OS) ZBTB8OS ARCH Bos taurus (Bovine) 167 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0006388; GO:0046872; GO:0072669 0 0 0 PF01951; Q3SWX9 CHOYP_LOC100376067.2.3 m.62388 sp RAD21_BOVIN 42.105 266 124 8 452 701 213 464 1.32E-37 153 RAD21_BOVIN reviewed Double-strand-break repair protein rad21 homolog RAD21 Bos taurus (Bovine) 630 apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168] GO:0000775; GO:0000785; GO:0001228; GO:0005654; GO:0006281; GO:0006915; GO:0007059; GO:0007067; GO:0016020; GO:0034991; GO:0051301; GO:0071168 0 0 0 PF04824;PF04825; Q4ZJM9 CHOYP_LOC100698013.1.1 m.5420 sp C1QL4_MOUSE 32.117 137 77 6 93 224 111 236 1.32E-06 51.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q54KA7 CHOYP_AFUA_1G01020.49.50 m.65372 sp SECG_DICDI 39.167 240 129 3 25 248 204 442 1.32E-38 145 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q55E58 CHOYP_BRAFLDRAFT_63321.1.1 m.14099 sp PATS1_DICDI 26.148 283 158 10 205 481 1793 2030 1.32E-14 80.9 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q58EL2 CHOYP_AGAP_AGAP007501.1.1 m.7357 sp TMM35_DANRE 36.306 157 92 2 21 177 4 152 1.32E-25 100 TMM35_DANRE reviewed Transmembrane protein 35 tmem35 zgc:110832 Danio rerio (Zebrafish) (Brachydanio rerio) 160 0 GO:0005778; GO:0016021; GO:0016023 0 0 0 PF13564; Q5RBN9 CHOYP_LOC100893166.1.2 m.10277 sp TAD2B_PONAB 44.671 441 211 5 8 443 3 415 1.32E-133 394 TAD2B_PONAB reviewed Transcriptional adapter 2-beta TADA2B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 420 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00249; Q5REH3 CHOYP_SYR.1.1 m.16766 sp SYRM_PONAB 37.354 514 293 11 93 603 88 575 1.32E-96 310 SYRM_PONAB reviewed "Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)" RARS2 RARSL Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 578 arginyl-tRNA aminoacylation [GO:0006420] GO:0004814; GO:0005524; GO:0005759; GO:0006420 0 0 0 PF05746;PF00750; Q5XHZ6 CHOYP_KLHL7.1.1 m.9443 sp KLHL7_RAT 29.437 231 155 4 102 328 29 255 1.32E-19 94.7 KLHL7_RAT reviewed Kelch-like protein 7 Klhl7 Rattus norvegicus (Rat) 586 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005654; GO:0005730; GO:0005737; GO:0005886; GO:0016567; GO:0031463; GO:0042787; GO:0042803 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q5ZJ75 CHOYP_CPIPJ_CPIJ001137.2.2 m.40788 sp SL9A8_CHICK 61.458 192 71 1 85 273 44 235 1.32E-71 236 SL9A8_CHICK reviewed Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) 0 Gallus gallus (Chicken) 574 regulation of pH [GO:0006885] GO:0000139; GO:0006885; GO:0015385; GO:0016021 0 0 0 PF00999; Q69Z37 CHOYP_LOC100367581.3.3 m.56472 sp SAM9L_MOUSE 23.465 1466 958 59 337 1730 187 1560 1.32E-70 266 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6DE75 CHOYP_LOC100544135.1.2 m.43772 sp S2538_XENLA 54.348 92 42 0 37 128 210 301 1.32E-27 107 S2538_XENLA reviewed Solute carrier family 25 member 38 slc25a38 Xenopus laevis (African clawed frog) 302 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783] GO:0005215; GO:0005743; GO:0006783; GO:0016021; GO:0030218 0 0 0 PF00153; Q6DIL6 CHOYP_NEMVEDRAFT_V1G167866.1.1 m.22179 sp F124A_XENTR 28.226 248 164 5 19 262 21 258 1.32E-24 107 F124A_XENTR reviewed Protein FAM124A fam124a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 503 0 0 0 0 0 PF15067; Q6P6J9 CHOYP_LOC100877516.1.1 m.37233 sp TXD15_MOUSE 43.333 180 96 4 188 364 142 318 1.32E-41 152 TXD15_MOUSE reviewed Thioredoxin domain-containing protein 15 Txndc15 Mus musculus (Mouse) 344 cell redox homeostasis [GO:0045454] GO:0005623; GO:0016021; GO:0045454 0 0 0 PF00085; Q6PCQ0 CHOYP_LOC100888457.2.2 m.61081 sp IQCE_MOUSE 27.381 504 297 13 172 664 135 580 1.32E-36 151 IQCE_MOUSE reviewed IQ domain-containing protein E Iqce Mus musculus (Mouse) 778 0 GO:0005739 0 0 0 PF00612; Q6PFY8 CHOYP_DICPUDRAFT_159150.1.1 m.55171 sp TRI45_MOUSE 26.627 169 102 4 4 159 162 321 1.32E-07 57 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6Q899 CHOYP_IFIH1.5.14 m.43198 sp DDX58_MOUSE 29.32 897 533 33 1 838 43 897 1.32E-90 310 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6ZMV7 CHOYP_LOC757085.1.1 m.6544 sp LEKR1_HUMAN 30.728 371 236 4 317 668 3 371 1.32E-36 145 LEKR1_HUMAN reviewed "Leucine-, glutamate- and lysine-rich protein 1" LEKR1 Homo sapiens (Human) 388 0 0 0 0 0 0 Q6ZQ12 CHOYP_NINL.2.2 m.58109 sp NINL_MOUSE 27.945 798 443 26 169 912 99 818 1.32E-58 226 NINL_MOUSE reviewed Ninein-like protein Ninl Kiaa0980 Nlp Mus musculus (Mouse) 1394 microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005509; GO:0005737; GO:0005815; GO:0005856; GO:0005874 0 0 0 PF13499; Q7ZUX6 CHOYP_LOC100378204.1.1 m.40064 sp DOHH_DANRE 63.036 303 110 1 4 304 1 303 1.32E-133 384 DOHH_DANRE reviewed Deoxyhypusine hydroxylase (DOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) dohh zgc:56338 Danio rerio (Zebrafish) (Brachydanio rerio) 305 peptidyl-lysine modification to peptidyl-hypusine [GO:0008612] GO:0008612; GO:0019135; GO:0046872 PATHWAY: Protein modification; eIF5A hypusination. {ECO:0000255|HAMAP-Rule:MF_03101}. 0 0 0 Q8JHJ2 CHOYP_DDX55.2.2 m.30596 sp DDX55_DANRE 67.416 89 28 1 6 93 4 92 1.32E-32 122 DDX55_DANRE reviewed ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55) ddx55 Danio rerio (Zebrafish) (Brachydanio rerio) 593 multicellular organism development [GO:0007275]; RNA secondary structure unwinding [GO:0010501] GO:0003723; GO:0004004; GO:0005524; GO:0007275; GO:0010501 0 0 0 PF00270;PF13959;PF00271; Q8ML92 CHOYP_LOC100900546.1.1 m.12593 sp AVE_DROME 30 90 62 1 29 118 14 102 1.32E-15 71.2 AVE_DROME reviewed Protein aveugle ave CG30476 Drosophila melanogaster (Fruit fly) 106 compound eye cone cell differentiation [GO:0042675]; compound eye photoreceptor cell differentiation [GO:0001751]; epidermal growth factor receptor signaling pathway [GO:0007173]; eye photoreceptor cell differentiation [GO:0001754]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of Ras protein signal transduction [GO:0046579]; signal transduction [GO:0007165]; visual perception [GO:0007601] GO:0001751; GO:0001754; GO:0005737; GO:0005886; GO:0007165; GO:0007173; GO:0007601; GO:0042675; GO:0046579; GO:0070374 0 0 0 PF07647; Q8N5Z0 CHOYP_AADAT.1.1 m.12672 sp AADAT_HUMAN 52.358 424 200 2 1 422 1 424 1.32E-164 472 AADAT_HUMAN reviewed "Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (KAT/AadAT) (2-aminoadipate aminotransferase) (2-aminoadipate transaminase) (EC 2.6.1.39) (Alpha-aminoadipate aminotransferase) (AadAT) (Kynurenine aminotransferase II) (Kynurenine--oxoglutarate aminotransferase II) (Kynurenine--oxoglutarate transaminase 2) (EC 2.6.1.7) (Kynurenine--oxoglutarate transaminase II)" AADAT KAT2 Homo sapiens (Human) 425 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; glutamate metabolic process [GO:0006536]; kynurenine metabolic process [GO:0070189]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine catabolic process [GO:0006554]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0005759; GO:0006103; GO:0006536; GO:0006554; GO:0006569; GO:0009058; GO:0016212; GO:0019441; GO:0030170; GO:0033512; GO:0042803; GO:0047536; GO:0070189 PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6. 0 0 PF00155; Q8NDA2 CHOYP_LOC100901486.1.1 m.41823 sp HMCN2_HUMAN 22.505 551 347 25 62 567 2973 3488 1.32E-18 95.9 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8NFD2 CHOYP_TVAG_123950.4.31 m.32448 sp ANKK1_HUMAN 38.4 125 77 0 6 130 397 521 1.32E-21 92.4 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8Q0U0 CHOYP_RIPK4.1.1 m.100 sp Y045_METMA 33.456 272 177 3 30 298 53 323 1.32E-34 134 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q8R205 CHOYP_ZC3HA.1.1 m.27569 sp ZC3HA_MOUSE 39.303 402 205 11 22 395 39 429 1.32E-77 249 ZC3HA_MOUSE reviewed Zinc finger CCCH domain-containing protein 10 Zc3h10 Mus musculus (Mouse) 435 0 GO:0044822; GO:0046872 0 0 0 PF00642; Q8YTC2 CHOYP_LOC100367460.1.1 m.62925 sp Y2800_NOSS1 29 200 115 7 36 232 969 1144 1.32E-12 72.8 Y2800_NOSS1 reviewed Uncharacterized WD repeat-containing protein alr2800 alr2800 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 1258 0 GO:0043531 0 0 0 PF00931;PF00400; Q90773 CHOYP_LOC100121068.1.1 m.14660 sp CEPU1_CHICK 32.602 319 192 10 5 318 18 318 1.32E-38 145 CEPU1_CHICK reviewed Protein CEPU-1 0 Gallus gallus (Chicken) 353 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225 0 0 0 PF07679;PF00047; Q90YS3 CHOYP_RS2.2.10 m.5562 sp RS2_ICTPU 86.134 238 33 0 48 285 32 269 1.32E-149 427 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q91827 CHOYP_LOC100374347.1.2 m.22463 sp AR1_XENLA 37.222 180 104 4 11 186 46 220 1.32E-36 130 AR1_XENLA reviewed Apoptosis regulator R1 (XR1) (Fragment) 0 Xenopus laevis (African clawed frog) 228 apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] GO:0006915; GO:0016021; GO:0042981 0 0 0 PF00452;PF02180; Q98925 CHOYP_SMP_071470.1.1 m.30924 sp IRF2_CHICK 53.704 108 49 1 7 113 5 112 1.32E-39 138 IRF2_CHICK reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) 348 cell proliferation [GO:0008283] GO:0000977; GO:0001228; GO:0005654; GO:0005737; GO:0005925; GO:0008283 0 0 0 PF00605; Q9CYL5 CHOYP_ISCW_ISCW019177.3.4 m.63876 sp GAPR1_MOUSE 42.857 70 39 1 82 151 2 70 1.32E-09 57.4 GAPR1_MOUSE reviewed Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) Glipr2 Gapr1 Mus musculus (Mouse) 154 positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374 0 0 0 PF00188; Q9D0T2 CHOYP_LOC100678616.1.1 m.14684 sp DUS12_MOUSE 37.061 313 188 6 3 309 18 327 1.32E-68 220 DUS12_MOUSE reviewed Dual specificity protein phosphatase 12 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase T-DSP4) (Dual specificity phosphatase VH1) Dusp12 Mus musculus (Mouse) 339 positive regulation of glucokinase activity [GO:0033133] GO:0004725; GO:0005634; GO:0005737; GO:0005829; GO:0008138; GO:0008270; GO:0033133 0 0 0 PF00782; Q9D8X0 CHOYP_LOC101173625.3.3 m.38598 sp MANBL_MOUSE 58.491 53 16 3 34 84 8 56 1.32E-11 58.9 MANBL_MOUSE reviewed Protein MANBAL Manbal Mus musculus (Mouse) 85 0 GO:0016021 0 0 0 PF06783; Q9D994 CHOYP_LOC100892811.1.2 m.15426 sp WDR38_MOUSE 49.495 198 98 2 1 197 103 299 1.32E-58 189 WDR38_MOUSE reviewed WD repeat-containing protein 38 Wdr38 Mus musculus (Mouse) 303 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244 0 0 0 PF00400; Q9JIH2 CHOYP_LOC100748625.1.1 m.24479 sp NUP50_MOUSE 55.725 131 56 2 512 641 327 456 1.32E-37 149 NUP50_MOUSE reviewed Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) Nup50 Npap60 Mus musculus (Mouse) 466 mRNA transport [GO:0051028]; neural tube formation [GO:0001841]; protein import into nucleus [GO:0006606] GO:0001841; GO:0005643; GO:0005654; GO:0005737; GO:0006606; GO:0008536; GO:0030529; GO:0031965; GO:0051028 0 0 0 PF08911;PF00638; Q9R0D8 CHOYP_LOC101062578.1.1 m.56255 sp WDR54_MOUSE 42.773 339 169 8 1 325 1 328 1.32E-92 282 WDR54_MOUSE reviewed WD repeat-containing protein 54 Wdr54 D3Mm3e Mus musculus (Mouse) 334 0 0 0 0 0 0 Q9R1A7 CHOYP_VDR.1.1 m.53107 sp NR1I2_RAT 27.338 417 284 10 44 448 18 427 1.32E-40 153 NR1I2_RAT reviewed Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PXR) (Pregnane X receptor) Nr1i2 Pxr Rattus norvegicus (Rat) 431 "drug export [GO:0046618]; exogenous drug catabolic process [GO:0042738]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; xenobiotic metabolic process [GO:0006805]; xenobiotic transport [GO:0042908]" GO:0000977; GO:0001228; GO:0003707; GO:0004879; GO:0005634; GO:0006805; GO:0008144; GO:0008270; GO:0042738; GO:0042908; GO:0045892; GO:0045893; GO:0046618 0 0 0 PF00104;PF00105; Q9VAI0 CHOYP_GNA1.1.1 m.39198 sp GNA1_DROME 47.568 185 92 4 7 189 6 187 1.32E-52 170 GNA1_DROME reviewed Probable glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) CG1969 Drosophila melanogaster (Fruit fly) 219 UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0004343; GO:0006048 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. 0 0 PF00583; Q9VU68 CHOYP_LOC100373178.1.1 m.61013 sp WDR1_DROME 62.238 143 54 0 3 145 8 150 1.32E-61 204 WDR1_DROME reviewed Actin-interacting protein 1 (AIP1) (Protein flare) flr CG10724 Drosophila melanogaster (Fruit fly) 608 actin filament depolymerization [GO:0030042]; border follicle cell migration [GO:0007298]; establishment of planar polarity [GO:0001736]; imaginal disc-derived wing hair organization [GO:0035317]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; phagocytosis [GO:0006909]; regulation of actin filament depolymerization [GO:0030834]; regulation of actin filament polymerization [GO:0030833]; sarcomere organization [GO:0045214] GO:0001736; GO:0003779; GO:0005737; GO:0005856; GO:0006909; GO:0007298; GO:0030042; GO:0030833; GO:0030834; GO:0034316; GO:0035317; GO:0045214 0 0 0 PF00400; Q9WU49 CHOYP_BRAFLDRAFT_206907.11.11 m.60962 sp CHSP1_RAT 63.063 111 41 0 42 152 30 140 1.32E-44 146 CHSP1_RAT reviewed Calcium-regulated heat stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) Carhsp1 Rattus norvegicus (Rat) 147 "calcium-mediated signaling [GO:0019722]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000177; GO:0000932; GO:0003677; GO:0003730; GO:0005737; GO:0005829; GO:0006355; GO:0019722; GO:0043186; GO:0043488; GO:0070062 0 0 cd04458; PF00313; Q9Y6R7 CHOYP_BRAFLDRAFT_66204.2.3 m.18934 sp FCGBP_HUMAN 22.018 436 295 14 318 739 22 426 1.32E-11 72.4 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A7MAZ3 CHOYP_UBA5.2.2 m.12213 sp UBA5_BOVIN 54.444 90 37 3 13 100 317 404 1.33E-19 84.7 UBA5_BOVIN reviewed Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1) UBA5 UBE1DC1 Bos taurus (Bovine) 404 cyclic threonylcarbamoyladenosine biosynthetic process [GO:0061504]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976] GO:0005524; GO:0005634; GO:0005829; GO:0033146; GO:0034976; GO:0046872; GO:0061503; GO:0061504; GO:0071566; GO:0071569; GO:1990592 0 0 0 PF00899; A7SCH8 CHOYP_LOC100485536.1.1 m.48204 sp KYNU_NEMVE 49.701 501 209 2 31 530 2 460 1.33E-169 491 KYNU_NEMVE reviewed Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase) kynu v1g235255 Nematostella vectensis (Starlet sea anemone) 465 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; L-kynurenine catabolic process [GO:0097053]; quinolinate biosynthetic process [GO:0019805]; tryptophan catabolic process [GO:0006569] GO:0005737; GO:0006569; GO:0019805; GO:0030170; GO:0030429; GO:0034354; GO:0043420; GO:0097053 PATHWAY: Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_03017}.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. {ECO:0000255|HAMAP-Rule:MF_03017}. 0 0 PF00266; A8KBF3 CHOYP_NEMVEDRAFT_V1G127599.1.1 m.66722 sp PIWL2_XENTR 58.14 129 52 1 2 128 608 736 1.33E-45 161 PIWL2_XENTR reviewed Piwi-like protein 2 piwil2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 949 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; gamete generation [GO:0007276]; gene silencing by RNA [GO:0031047]; germ-line stem cell population maintenance [GO:0030718]; meiotic nuclear division [GO:0007126]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; regulation of translation [GO:0006417]; RNA 5'-end processing [GO:0000966] GO:0000966; GO:0005634; GO:0005737; GO:0006417; GO:0007126; GO:0007275; GO:0007276; GO:0030154; GO:0030718; GO:0031047; GO:0034584; GO:0034587; GO:0043046; GO:0043186; GO:0071546; GO:1990923 0 0 0 PF08699;PF02170;PF02171; O00468 CHOYP_AGRIN.3.5 m.5652 sp AGRIN_HUMAN 30.137 146 82 7 7 145 469 601 1.33E-08 56.2 AGRIN_HUMAN reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Homo sapiens (Human) 2067 clustering of voltage-gated sodium channels [GO:0045162]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0001523; GO:0002162; GO:0005200; GO:0005509; GO:0005576; GO:0005605; GO:0005737; GO:0005796; GO:0005886; GO:0006024; GO:0006027; GO:0007165; GO:0007213; GO:0016021; GO:0030054; GO:0030198; GO:0030203; GO:0031012; GO:0033691; GO:0035374; GO:0043113; GO:0043202; GO:0043236; GO:0043395; GO:0043547; GO:0045162; GO:0045202; GO:0045887; GO:0045944; GO:0050808; GO:0051491; GO:0070062 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF03146;PF01390; O05389 CHOYP_NEMVEDRAFT_V1G188927.1.1 m.17076 sp YRBE_BACSU 33.533 334 218 3 3 335 4 334 1.33E-63 208 YRBE_BACSU reviewed Uncharacterized oxidoreductase YrbE (EC 1.-.-.-) yrbE BSU27770 Bacillus subtilis (strain 168) 341 oxidation-reduction process [GO:0055114] GO:0016491; GO:0055114 0 0 0 PF01408;PF02894; O14522 CHOYP_PTPRT.33.45 m.55482 sp PTPRT_HUMAN 30.857 350 209 6 367 691 743 1084 1.33E-46 182 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O35015 CHOYP_BRAFLDRAFT_94936.1.1 m.4797 sp YNGK_BACSU 37.8 500 276 10 33 504 12 504 1.33E-106 330 YNGK_BACSU reviewed UPF0748 protein YngK yngK yotA BSU18280 Bacillus subtilis (strain 168) 510 0 GO:0030288 0 0 0 PF02638; O54890 CHOYP_LOC100018342.1.1 m.35113 sp ITB3_MOUSE 34.33 769 460 24 29 777 38 781 1.33E-146 452 ITB3_MOUSE reviewed Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) Itgb3 Mus musculus (Mouse) 787 activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cell adhesion mediated by integrin [GO:0033627]; cell growth [GO:0016049]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell projection morphogenesis [GO:0048858]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045715]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of extracellular matrix organization [GO:1903053]; regulation of protein tyrosine kinase activity [GO:0061097]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; viral entry into host cell [GO:0046718] GO:0001938; GO:0001954; GO:0001968; GO:0002020; GO:0003756; GO:0004872; GO:0005178; GO:0005634; GO:0005886; GO:0005925; GO:0007044; GO:0007160; GO:0007229; GO:0008305; GO:0009897; GO:0009986; GO:0010595; GO:0010628; GO:0010745; GO:0010763; GO:0010888; GO:0014909; GO:0016049; GO:0016324; GO:0016477; GO:0019899; GO:0030168; GO:0030334; GO:0030335; GO:0031258; GO:0031527; GO:0031528; GO:0031589; GO:0032147; GO:0032369; GO:0032587; GO:0032956; GO:0033627; GO:0033690; GO:0034113; GO:0034446; GO:0034679; GO:0034683; GO:0035867; GO:0036120; GO:0038027; GO:0042470; GO:0042802; GO:0043184; GO:0043235; GO:0045672; GO:0045715; GO:0045780; GO:0046718; GO:0048008; GO:0048146; GO:0048858; GO:0050731; GO:0050748; GO:0050839; GO:0050840; GO:0050919; GO:0060055; GO:0061097; GO:0070062; GO:0070527; GO:0071133; GO:1900026; GO:1903053; GO:2000406 0 0 0 PF07974;PF08725;PF07965;PF00362; O57592 CHOYP_RL7A.4.6 m.17134 sp RL7A_TAKRU 76.786 168 36 2 13 180 16 180 1.33E-89 266 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O61462 CHOYP_RL37A.4.7 m.39981 sp RL37A_CRYST 80 90 18 0 16 105 3 92 1.33E-47 150 RL37A_CRYST reviewed 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) 92 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046872 0 0 0 PF01780; O70277 CHOYP_BRAFLDRAFT_205659.1.1 m.20607 sp TRIM3_RAT 28.846 104 71 2 70 171 627 729 1.33E-08 56.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_71616.3.3 m.42089 sp TRIM3_RAT 27.211 147 101 3 121 263 599 743 1.33E-09 62.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_CRE_17674.2.2 m.53234 sp MEGF6_HUMAN 29.2 250 128 15 237 457 1161 1390 1.33E-07 58.2 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O88801 CHOYP_HOME2.1.1 m.43931 sp HOME2_RAT 70.543 129 37 1 45 172 3 131 1.33E-61 197 HOME2_RAT reviewed Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2) Homer2 Vesl2 Rattus norvegicus (Rat) 354 sensory perception of sound [GO:0007605] GO:0005730; GO:0005737; GO:0007605; GO:0014069; GO:0019904; GO:0030054; GO:0030425; GO:0032426; GO:0035254; GO:0035256; GO:0042803; GO:0043025; GO:0045211; GO:0046982 0 0 0 PF00568; O94431 CHOYP_LOC100183535.1.2 m.3337 sp EGT2_SCHPO 29.25 400 246 10 47 429 7 386 1.33E-43 160 EGT2_SCHPO reviewed Hercynylcysteine sulfoxide lyase (EC 4.4.1.-) (Ergothioneine biosynthesis protein 2) (PLP-binding cysteine desulfurase) (PLP-dependent C-S lyase) egt2 SPBC660.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 392 ergothioneine biosynthetic process [GO:0052699]; selenoneine biosynthetic process [GO:1903257] GO:0005634; GO:0005829; GO:0052699; GO:1903257; GO:1990411; GO:1990412 PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis. {ECO:0000269|PubMed:24828577}. 0 0 PF00266; P01122 CHOYP_RHO.1.1 m.2313 sp RHO_APLCA 95.833 192 8 0 1 192 1 192 1.33E-131 369 RHO_APLCA reviewed Ras-like GTP-binding protein RHO RHO Aplysia californica (California sea hare) 192 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264 0 0 0 PF00071; P04323 CHOYP_contig_014865 m.17138 sp POL3_DROME 38.71 155 95 0 2 156 312 466 1.33E-32 125 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P17078 CHOYP_RL35.4.4 m.63622 sp RL35_RAT 77.869 122 27 0 1 122 1 122 1.33E-59 182 RL35_RAT reviewed 60S ribosomal protein L35 Rpl35 Rattus norvegicus (Rat) 123 "cellular response to UV-B [GO:0071493]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; translation [GO:0006412]" GO:0000463; GO:0003729; GO:0003735; GO:0006412; GO:0022625; GO:0043021; GO:0071493 0 0 cd00427; PF00831; P20072 CHOYP_ANXA4.2.2 m.57444 sp ANXA7_BOVIN 62.416 149 56 0 4 152 153 301 1.33E-60 197 ANXA7_BOVIN reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 Bos taurus (Bovine) 463 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005509; GO:0005544; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0030855; GO:0035176; GO:0042584; GO:0042802; GO:0044822; GO:0048306; GO:0070062 0 0 0 PF00191; P25324 CHOYP_THTR.1.1 m.25923 sp THTR_CHICK 40.141 284 159 5 26 306 7 282 1.33E-67 216 THTR_CHICK reviewed Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) TST Gallus gallus (Chicken) 289 rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029] GO:0004792; GO:0005759; GO:0008097; GO:0035928; GO:0051029 0 0 0 PF00581; P27604 CHOYP_SAHH3.2.2 m.51224 sp SAHH_CAEEL 87.952 83 10 0 54 136 89 171 1.33E-47 162 SAHH_CAEEL reviewed Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (Protein dumpy-14) (S-adenosyl-L-homocysteine hydrolase) ahcy-1 ahh dpy-14 K02F2.2 Caenorhabditis elegans 437 one-carbon metabolic process [GO:0006730]; S-adenosylhomocysteine catabolic process [GO:0019510]; S-adenosylmethionine cycle [GO:0033353] GO:0004013; GO:0005829; GO:0006730; GO:0019510; GO:0033353 PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. 0 cd00401; PF05221;PF00670; P28825 CHOYP_NEMVEDRAFT_V1G120119.1.2 m.6082 sp MEP1A_MOUSE 27.226 393 239 20 25 394 64 432 1.33E-23 106 MEP1A_MOUSE reviewed Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (MEP-1) Mep1a Mus musculus (Mouse) 747 0 GO:0004222; GO:0008270; GO:0016020; GO:0016021; GO:0070062 0 0 cd06263; PF01400;PF00008;PF00629; P36544 CHOYP_ACHA6.3.4 m.62312 sp ACHA7_HUMAN 29.296 355 231 7 40 381 24 371 1.33E-47 173 ACHA7_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 NACHRA7 Homo sapiens (Human) 502 "activation of MAPK activity [GO:0000187]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; cognition [GO:0050890]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; memory [GO:0007613]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0000187; GO:0001540; GO:0001666; GO:0004889; GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0007613; GO:0008284; GO:0015276; GO:0015464; GO:0015643; GO:0016021; GO:0017081; GO:0022848; GO:0030054; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042803; GO:0045211; GO:0045766; GO:0050890 0 0 0 PF02931;PF02932; P41777 CHOYP_NOLC1.3.3 m.66629 sp NOLC1_RAT 62.887 97 35 1 663 758 608 704 1.33E-31 135 NOLC1_RAT reviewed Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) Nolc1 Rattus norvegicus (Rat) 704 "box H/ACA snoRNA metabolic process [GO:0033979]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of protein import into nucleus [GO:0042306]; response to osmotic stress [GO:0006970]" GO:0003700; GO:0005524; GO:0005525; GO:0005654; GO:0005730; GO:0005737; GO:0006970; GO:0008134; GO:0008139; GO:0008284; GO:0019904; GO:0033979; GO:0034512; GO:0034513; GO:0042306; GO:0045893 0 0 0 PF05022; P49013 CHOYP_BP10.3.3 m.55585 sp FBP3_STRPU 38.697 261 135 10 659 913 256 497 1.33E-34 144 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P56719 CHOYP_OPSD1.2.2 m.25626 sp OX2R_RAT 25.313 320 214 9 40 337 63 379 1.33E-13 75.1 OX2R_RAT reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0004930; GO:0005887; GO:0007186; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P68827 CHOYP_LOC101159945.2.2 m.52271 sp NAGPA_BOVIN 51.485 202 95 3 1 200 222 422 1.33E-65 219 NAGPA_BOVIN reviewed N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) NAGPA Bos taurus (Bovine) 527 protein glycosylation [GO:0006486] GO:0003944; GO:0006486; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09992; P74148 CHOYP_NCAH.1.5 m.8672 sp Y1388_SYNY3 22 150 110 1 7 149 5 154 1.33E-08 54.3 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q01518 CHOYP_LOC101078542.1.1 m.44610 sp CAP1_HUMAN 46.46 226 116 2 116 340 2 223 1.33E-61 207 CAP1_HUMAN reviewed Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 CAP Homo sapiens (Human) 475 actin polymerization or depolymerization [GO:0008154]; activation of adenylate cyclase activity [GO:0007190]; ameboidal-type cell migration [GO:0001667]; cell morphogenesis [GO:0000902]; establishment or maintenance of cell polarity [GO:0007163]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165] GO:0000902; GO:0001667; GO:0003779; GO:0005886; GO:0005925; GO:0006898; GO:0007163; GO:0007165; GO:0007190; GO:0008154; GO:0008179; GO:0030864; GO:0070062 0 0 0 PF08603;PF01213; Q11082 CHOYP_SMP_072450.2.2 m.25089 sp YT66_CAEEL 25.08 311 195 7 42 332 29 321 1.33E-11 69.3 YT66_CAEEL reviewed Probable G-protein coupled receptor B0563.6 B0563.6 Caenorhabditis elegans 434 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q14094 CHOYP_BRAFLDRAFT_265991.1.1 m.58764 sp CCNI_HUMAN 37.188 320 147 4 44 310 44 362 1.33E-66 216 CCNI_HUMAN reviewed Cyclin-I CCNI Homo sapiens (Human) 377 regulation of cell cycle [GO:0051726]; spermatogenesis [GO:0007283] GO:0007283; GO:0051726 0 0 0 PF00134; Q14094 CHOYP_MYS.1.7 m.434 sp CCNI_HUMAN 37.188 320 147 4 44 310 44 362 1.33E-66 216 CCNI_HUMAN reviewed Cyclin-I CCNI Homo sapiens (Human) 377 regulation of cell cycle [GO:0051726]; spermatogenesis [GO:0007283] GO:0007283; GO:0051726 0 0 0 PF00134; Q14094 CHOYP_TBC13.1.1 m.24397 sp CCNI_HUMAN 37.188 320 147 4 44 310 44 362 1.33E-66 216 CCNI_HUMAN reviewed Cyclin-I CCNI Homo sapiens (Human) 377 regulation of cell cycle [GO:0051726]; spermatogenesis [GO:0007283] GO:0007283; GO:0051726 0 0 0 PF00134; Q28983 CHOYP_FCGBP.1.4 m.29066 sp ZAN_PIG 28.254 1352 769 46 511 1831 784 1965 1.33E-131 464 ZAN_PIG reviewed Zonadhesin ZAN Sus scrofa (Pig) 2476 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840 0 0 cd06263; PF08742;PF00008;PF00629;PF01826;PF12714;PF00094; Q2HJ23 CHOYP_MGC68744.1.1 m.23059 sp MLP3A_BOVIN 75 120 30 0 15 134 1 120 1.33E-62 190 MLP3A_BOVIN reviewed Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (MAP1A/MAP1B light chain 3 A) (MAP1A/MAP1B LC3 A) (Microtubule-associated protein 1 light chain 3 alpha) MAP1LC3A Bos taurus (Bovine) 121 autophagosome assembly [GO:0000045]; cellular response to nitrogen starvation [GO:0006995]; mitophagy [GO:0000422] GO:0000045; GO:0000421; GO:0000422; GO:0005543; GO:0005776; GO:0005829; GO:0005874; GO:0006995; GO:0008017; GO:0008429; GO:0012505; GO:0031090; GO:0031410 0 0 cd01611; PF02991; Q2HZX7 CHOYP_FUZZY.1.1 m.14293 sp FUZZY_XENTR 45.499 411 212 4 4 404 7 415 1.33E-117 352 FUZZY_XENTR reviewed Protein fuzzy homolog (Xfy) fuz fuzzy fy Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 418 cilium assembly [GO:0042384]; embryonic body morphogenesis [GO:0010172]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of planar polarity [GO:0001736]; neural tube closure [GO:0001843]; protein transport [GO:0015031]; regulation of smoothened signaling pathway [GO:0008589] GO:0001736; GO:0001843; GO:0005737; GO:0005856; GO:0008589; GO:0010172; GO:0015031; GO:0042384; GO:0048704 0 0 0 0 Q2TGI5 CHOYP_BRAFLDRAFT_121223.1.1 m.18305 sp ZDH24_RAT 34.848 198 127 2 96 291 78 275 1.33E-34 130 ZDH24_RAT reviewed Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Membrane-associated zinc finger protein DHHC25) (Zinc finger DHHC domain-containing protein 24) (DHHC-24) Zdhhc24 Rattus norvegicus (Rat) 284 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q3A8Q0 CHOYP_NEMVEDRAFT_V1G194582.2.2 m.40728 sp PDXT_CARHZ 43.779 217 94 7 13 228 1 190 1.33E-49 164 PDXT_CARHZ reviewed Pyridoxal 5'-phosphate synthase subunit PdxT (EC 4.3.3.6) (Pdx2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) pdxT CHY_2702 Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) 191 glutamine catabolic process [GO:0006543]; pyridoxal phosphate biosynthetic process [GO:0042823]; vitamin B6 biosynthetic process [GO:0042819] GO:0004359; GO:0006543; GO:0036381; GO:0042819; GO:0042823 PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01615}. 0 cd01749; PF01174; Q3TTI8 CHOYP_BRAFLDRAFT_69423.2.2 m.49428 sp YL021_MOUSE 29.787 188 118 3 8 195 40 213 1.33E-18 87 YL021_MOUSE reviewed Uncharacterized protein ENSP00000372125 homolog 0 Mus musculus (Mouse) 308 0 0 0 0 0 PF15046; Q3UCV8 CHOYP_LOC100177299.2.2 m.44810 sp OTUL_MOUSE 33.913 115 72 3 22 136 80 190 1.33E-14 72 OTUL_MOUSE reviewed Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby) Otulin Fam105b Gum Mus musculus (Mouse) 352 canonical Wnt signaling pathway [GO:0060070]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; protein linear deubiquitination [GO:1990108]; sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004843; GO:0005737; GO:0008234; GO:0032088; GO:0045087; GO:0050728; GO:0060070; GO:0070431; GO:1990108 0 0 0 PF16218; Q3UZZ6 CHOYP_ST1E1.2.2 m.63291 sp ST1D1_MOUSE 32.37 173 103 5 29 191 19 187 1.33E-26 105 ST1D1_MOUSE reviewed Sulfotransferase 1 family member D1 (ST1D1) (EC 2.8.2.-) (Amine N-sulfotransferase) (SULT-N) (Dopamine sulfotransferase Sult1d1) (Tyrosine-ester sulfotransferase) Sult1d1 St1d1 Mus musculus (Mouse) 295 catecholamine metabolic process [GO:0006584]; lipid metabolic process [GO:0006629]; sulfate assimilation [GO:0000103]; sulfation [GO:0051923] GO:0000103; GO:0004062; GO:0005737; GO:0006584; GO:0006629; GO:0008146; GO:0051923 0 0 0 PF00685; Q4VA61 CHOYP_DSCL1.1.1 m.37890 sp DSCL1_MOUSE 22.222 594 362 28 38 579 329 874 1.33E-10 68.9 DSCL1_MOUSE reviewed Down syndrome cell adhesion molecule-like protein 1 homolog Dscaml1 Mus musculus (Mouse) 2053 brain development [GO:0007420]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; dendrite self-avoidance [GO:0070593]; embryonic skeletal system morphogenesis [GO:0048704]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162] GO:0005615; GO:0005886; GO:0007156; GO:0007162; GO:0007420; GO:0009986; GO:0016021; GO:0016338; GO:0030054; GO:0042803; GO:0045202; GO:0048704; GO:0070593 0 0 0 PF00041;PF07679; Q4ZJM9 CHOYP_LOC100377510.1.4 m.1903 sp C1QL4_MOUSE 32.308 130 74 6 54 176 110 232 1.33E-08 55.8 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q4ZJM9 CHOYP_LOC101169268.2.2 m.51423 sp C1QL4_MOUSE 36.364 110 64 3 81 186 128 235 1.33E-08 56.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5F359 CHOYP_LOC100892925.1.2 m.44655 sp TPPC5_CHICK 56.643 143 62 0 4 146 3 145 1.33E-56 184 TPPC5_CHICK reviewed Trafficking protein particle complex subunit 5 TRAPPC5 RCJMB04_33f11 Gallus gallus (Chicken) 188 vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005794; GO:0016192 0 0 cd14943; PF04051; Q5ZKJ5 CHOYP_LOC586645.1.1 m.62321 sp MF13A_CHICK 26.585 489 316 11 11 470 18 492 1.33E-43 163 MF13A_CHICK reviewed Transmembrane protein 180 (Major facilitator superfamily domain-containing 13A) MFSD13A TMEM180 RCJMB04_10g6 Gallus gallus (Chicken) 509 0 GO:0016021 0 0 0 0 Q60710 CHOYP_LOC100706185.1.1 m.56607 sp SAMH1_MOUSE 38.809 487 222 12 625 1072 117 566 1.33E-90 307 SAMH1_MOUSE reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Interferon-gamma-inducible protein Mg11) (SAM domain and HD domain-containing protein 1) Samhd1 Mg11 Mus musculus (Mouse) 627 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0005654; GO:0005886; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051289; GO:0051607 0 0 0 PF01966;PF07647; Q62158 CHOYP_LOC100374741.1.83 m.667 sp TRI27_MOUSE 25.616 203 116 8 18 194 70 263 1.33E-06 53.5 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q68EY7 CHOYP_C124A.1.1 m.61913 sp C124A_XENLA 57.209 215 85 5 1 211 1 212 1.33E-63 199 C124A_XENLA reviewed Coiled-coil domain-containing protein 124-A ccdc124-a Xenopus laevis (African clawed frog) 217 cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005737; GO:0005815; GO:0007049; GO:0030496; GO:0051301 0 0 0 PF06244; Q6GNL4 CHOYP_RSG1.1.1 m.36455 sp RSG1_XENLA 41.667 240 130 2 7 238 6 243 1.33E-68 214 RSG1_XENLA reviewed REM2- and Rab-like small GTPase 1 rsg1 Xenopus laevis (African clawed frog) 249 cellular protein localization [GO:0034613]; cilium assembly [GO:0042384]; exocytosis [GO:0006887]; neural tube closure [GO:0001843]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of vesicle fusion [GO:0031338]; small GTPase mediated signal transduction [GO:0007264] GO:0001843; GO:0005525; GO:0005737; GO:0006887; GO:0007264; GO:0015031; GO:0017157; GO:0031338; GO:0034613; GO:0036064; GO:0042384 0 0 0 PF00071; Q6NXI6 CHOYP_LOC100889738.1.1 m.41184 sp RPRD2_MOUSE 37.845 362 187 4 13 346 27 378 1.33E-70 260 RPRD2_MOUSE reviewed Regulation of nuclear pre-mRNA domain-containing protein 2 Rprd2 Kiaa0460 Mus musculus (Mouse) 1469 0 GO:0016591 0 0 0 PF16566;PF04818; Q6PA06 CHOYP_ATLA2.2.2 m.55840 sp ATLA2_MOUSE 38.877 463 260 9 5 456 53 503 1.33E-102 320 ATLA2_MOUSE reviewed Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) Atl2 Arl6ip2 Mus musculus (Mouse) 583 endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0007029; GO:0007030; GO:0016020; GO:0016021; GO:0042802; GO:0051260 0 0 0 PF02263; Q6Q899 CHOYP_DDX58.5.9 m.29122 sp DDX58_MOUSE 28.371 927 595 28 111 997 20 917 1.33E-85 299 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6R7D7 CHOYP_Y093.1.1 m.27705 sp Y092_OSHVF 100 229 0 0 1 229 1 229 1.33E-166 461 Y092_OSHVF reviewed Uncharacterized protein ORF92 ORF92 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 229 0 0 0 0 0 0 Q6R7E2 CHOYP_GBLP.3.7 m.20933 sp IAP2_OSHVF 35.149 202 93 7 9 205 2 170 1.33E-28 108 IAP2_OSHVF reviewed Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 170 0 0 0 0 0 PF00653; Q6TFL4 CHOYP_KLHL24.3.4 m.21575 sp KLH24_HUMAN 29.512 471 326 3 31 501 56 520 1.33E-65 230 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q6ZS10 CHOYP_CLEC17A.1.1 m.28486 sp CL17A_HUMAN 31.973 147 89 4 6 152 240 375 1.33E-13 70.5 CL17A_HUMAN reviewed "C-type lectin domain family 17, member A (Prolectin)" CLEC17A Homo sapiens (Human) 378 0 GO:0005537; GO:0009986; GO:0016021; GO:0042806; GO:0046872 0 0 0 PF00059; Q7T163 CHOYP_LOC100637968.9.12 m.48231 sp KDIS_DANRE 30.909 385 239 15 95 467 4 373 1.33E-25 114 KDIS_DANRE reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) 1672 nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; regulation of protein kinase activity [GO:0045859] GO:0005770; GO:0007399; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0045859 0 0 0 PF00023;PF12796;PF07693; Q7Z6J2 CHOYP_AGAP_AGAP006605.1.1 m.53590 sp GRASP_HUMAN 36.296 135 85 1 48 181 97 231 1.33E-18 91.3 GRASP_HUMAN reviewed General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) GRASP Homo sapiens (Human) 395 protein localization [GO:0008104]; signal transduction [GO:0007165] GO:0007165; GO:0008104; GO:0030054; GO:0045211; GO:0048471 0 0 0 PF00595; Q80TZ9 CHOYP_CARNS1.5.6 m.63614 sp RERE_MOUSE 48.441 417 167 12 9 385 314 722 1.33E-95 338 RERE_MOUSE reviewed Arginine-glutamic acid dipeptide repeats protein (Atrophin-2) Rere Atr2 Kiaa0458 Mus musculus (Mouse) 1558 branching morphogenesis of a nerve [GO:0048755]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell layer maturation [GO:0021691]; cerebellum development [GO:0021549]; chromatin remodeling [GO:0006338]; dendrite morphogenesis [GO:0048813]; radial glia guided migration of Purkinje cell [GO:0021942] GO:0000118; GO:0001105; GO:0001106; GO:0003682; GO:0003700; GO:0005634; GO:0006338; GO:0008270; GO:0016605; GO:0021549; GO:0021691; GO:0021930; GO:0021942; GO:0043565; GO:0048755; GO:0048813 0 0 0 PF03154;PF01426;PF01448;PF00320; Q8C4U2 CHOYP_TM145.2.2 m.26667 sp TM145_MOUSE 46.895 467 230 8 25 485 32 486 1.33E-135 415 TM145_MOUSE reviewed Transmembrane protein 145 Tmem145 Mus musculus (Mouse) 746 G-protein coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] GO:0007186; GO:0016021; GO:0019236 0 0 0 PF10192; Q8C7M3 CHOYP_LOC100373444.56.79 m.53283 sp TRIM9_MOUSE 22.273 220 152 6 10 214 165 380 1.33E-06 54.7 TRIM9_MOUSE reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) Trim9 Kiaa0282 Mus musculus (Mouse) 817 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; synaptic vesicle exocytosis [GO:0016079] GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016079; GO:0016874; GO:0030054; GO:0030425; GO:0042803; GO:0043161 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643; Q8NBH2 CHOYP_KY.4.5 m.56656 sp KY_HUMAN 32.484 314 188 9 24 336 148 438 1.33E-39 151 KY_HUMAN reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) KY Homo sapiens (Human) 561 0 GO:0005856; GO:0008233; GO:0030018 0 0 0 PF01841; Q8R059 CHOYP_LOC100370520.1.1 m.12258 sp GALE_MOUSE 65 340 113 2 27 360 4 343 1.33E-173 489 GALE_MOUSE reviewed UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-galactose 4-epimerase) Gale Mus musculus (Mouse) 347 galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623] GO:0003974; GO:0003978; GO:0006012; GO:0019388; GO:0033499; GO:0042803; GO:0061623; GO:0070062 PATHWAY: Carbohydrate metabolism; galactose metabolism. 0 0 PF16363; Q8TCT9 CHOYP_BRAFLDRAFT_87838.1.1 m.66264 sp HM13_HUMAN 62.599 377 132 3 3 371 2 377 1.33E-174 493 HM13_HUMAN reviewed Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase) HM13 H13 IMP1 PSL3 SPP MSTP086 Homo sapiens (Human) 377 "membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; protein homotetramerization [GO:0051289]; signal peptide processing [GO:0006465]" GO:0005765; GO:0005783; GO:0005789; GO:0005791; GO:0005886; GO:0006465; GO:0008233; GO:0009986; GO:0016020; GO:0030660; GO:0031625; GO:0033619; GO:0036513; GO:0042500; GO:0042803; GO:0051289; GO:0071458; GO:0071556; GO:1904211 0 0 0 PF04258; Q8TDB6 CHOYP_LOC100555386.1.3 m.34743 sp DTX3L_HUMAN 49.65 143 68 2 165 307 556 694 1.33E-35 139 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8UWD7 CHOYP_GDF8.2.3 m.35962 sp GDF8_SYNCH 25 372 254 9 82 441 16 374 1.33E-24 107 GDF8_SYNCH reviewed Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Synoicus chinensis (Blue-breasted quail) (Coturnix chinensis) 375 growth [GO:0040007]; muscle cell proliferation [GO:0033002]; negative regulation of myoblast proliferation [GO:2000818]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of skeletal muscle satellite cell proliferation [GO:1902723] GO:0005615; GO:0033002; GO:0040007; GO:1902723; GO:1902725; GO:2000818 0 0 0 PF00019;PF00688; Q96DM1 CHOYP_LOC100498109.3.3 m.55841 sp PGBD4_HUMAN 26.38 489 320 12 85 550 105 576 1.33E-41 161 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q96GP6 CHOYP_MEGF6.49.59 m.51077 sp SREC2_HUMAN 40.909 110 60 4 20 129 245 349 1.33E-14 72.4 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9BE18 CHOYP_LOC101243046.1.2 m.24593 sp MAGE1_MACFA 26.509 381 244 6 385 753 58 414 1.33E-18 95.5 MAGE1_MACFA reviewed Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (MAGE-E1 antigen) MAGEE1 QflA-10248 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 957 0 GO:0005634; GO:0005886; GO:0030425; GO:0045211; GO:0048471 0 0 0 PF01454; Q9BXJ4 CHOYP_LOC659383.2.2 m.60366 sp C1QT3_HUMAN 30 130 82 4 84 209 118 242 1.33E-06 50.8 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9FKA5 CHOYP_RCOM_0537780.1.1 m.24615 sp Y5957_ARATH 53.398 103 45 2 17 116 1 103 1.33E-23 97.1 Y5957_ARATH reviewed Uncharacterized protein At5g39570 At5g39570 MIJ24_40 Arabidopsis thaliana (Mouse-ear cress) 381 0 0 0 0 0 0 Q9IAT6 CHOYP_SLIT3.1.1 m.27328 sp DLLC_DANRE 34.211 152 82 4 208 341 304 455 1.33E-14 81.3 DLLC_DANRE reviewed Delta-like protein C (DeltaC) (delC) dlc Danio rerio (Zebrafish) (Brachydanio rerio) 664 arterial endothelial cell differentiation [GO:0060842]; blood vessel morphogenesis [GO:0048514]; dorsal aorta development [GO:0035907]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; sclerotome development [GO:0061056]; somite specification [GO:0001757]; somitogenesis [GO:0001756]; ventral spinal cord interneuron differentiation [GO:0021514] GO:0001756; GO:0001757; GO:0002244; GO:0005509; GO:0005737; GO:0005886; GO:0007219; GO:0016021; GO:0021514; GO:0030165; GO:0035907; GO:0042802; GO:0048471; GO:0048514; GO:0048666; GO:0060218; GO:0060842; GO:0061056 0 0 0 PF01414;PF00008;PF12661; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G199235.11.15 m.46596 sp SACS_HUMAN 30.692 896 525 26 58 922 2452 3282 1.33E-101 354 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9P720 CHOYP_COX1.10.15 m.40956 sp RL16_NEUCR 64.151 106 38 0 3 108 82 187 1.33E-44 147 RL16_NEUCR reviewed 60S ribosomal protein L16 (Cytoplasmic ribosomal protein 46) crp-46 rpl16 8D4.200 NCU01221 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 202 translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0022625 0 0 cd00392; PF00572; Q9VZW5 CHOYP_FR.2.2 m.44698 sp FMAR_DROME 28.529 340 212 12 82 410 126 445 1.33E-25 112 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; Q9Y248 CHOYP_BRAFLDRAFT_118797.2.2 m.18049 sp PSF2_HUMAN 63.584 173 63 0 1 173 1 173 1.33E-81 242 PSF2_HUMAN reviewed DNA replication complex GINS protein PSF2 (GINS complex subunit 2) GINS2 PSF2 CGI-122 DC5 HSPC037 Homo sapiens (Human) 185 DNA duplex unwinding [GO:0032508]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication initiation [GO:1902975] GO:0000727; GO:0000811; GO:0005654; GO:0006271; GO:0031298; GO:0032508; GO:1902975 0 0 0 PF05916; Q9Y385 CHOYP_UB2J1.1.1 m.63164 sp UB2J1_HUMAN 70.37 189 54 2 32 219 1 188 1.33E-92 288 UB2J1_HUMAN reviewed Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e) UBE2J1 NCUBE1 CGI-76 HSPC153 HSPC205 Homo sapiens (Human) 318 "ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein N-linked glycosylation via asparagine [GO:0018279]; regulation of tumor necrosis factor biosynthetic process [GO:0042534]; spermatid development [GO:0007286]" GO:0005524; GO:0005737; GO:0005789; GO:0007286; GO:0016021; GO:0018279; GO:0030433; GO:0031625; GO:0042534; GO:0061630; GO:0061631; GO:1904153 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; A3DC27 CHOYP_LOC101170950.1.1 m.43032 sp RSGI2_CLOTH 29.146 398 214 16 99 452 136 509 1.34E-11 70.9 RSGI2_CLOTH reviewed Anti-sigma-I factor RsgI2 rsgI2 Cthe_0267 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 671 carbohydrate metabolic process [GO:0005975] GO:0005886; GO:0005975; GO:0016021; GO:0030248; GO:0046872 0 0 0 PF00942;PF12791; A7E3W5 CHOYP_LOC100373178.1.1 m.61012 sp SNG2_BOVIN 43.172 227 115 4 6 226 3 221 1.34E-56 182 SNG2_BOVIN reviewed Synaptogyrin-2 (Cellugyrin) SYNGR2 Bos taurus (Bovine) 224 0 GO:0016021; GO:0030672; GO:0031594; GO:0070062 0 0 0 PF01284; A8K7I4 CHOYP_CLCA1.1.1 m.63606 sp CLCA1_HUMAN 31.229 903 545 27 12 882 12 870 1.34E-111 370 CLCA1_HUMAN reviewed Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 1) (hCLCA1) (Calcium-activated chloride channel protein 1) (CaCC-1) (hCaCC-1) CLCA1 CACC1 Homo sapiens (Human) 914 calcium ion transport [GO:0006816]; cellular response to hypoxia [GO:0071456]; ion transmembrane transport [GO:0034220]; transport [GO:0006810] GO:0004222; GO:0005229; GO:0005254; GO:0005615; GO:0005886; GO:0005887; GO:0005902; GO:0006810; GO:0006816; GO:0034220; GO:0042589; GO:0046872; GO:0071456 0 0 0 PF08434;PF13519; B3EWY9 CHOYP_contig_014692 m.16897 sp MLP_ACRMI 28.571 903 523 33 21 893 557 1367 1.34E-84 309 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B3N8M1 CHOYP_CSL2.1.1 m.58106 sp LPHN_DROER 35.156 128 71 3 15 142 23 138 1.34E-20 90.5 LPHN_DROER reviewed Latrophilin Cirl Cirl GG23370 Drosophila erecta (Fruit fly) 1710 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021; GO:0030246 0 0 0 PF16489;PF02140;PF01825; E1BD59 CHOYP_BRAFLDRAFT_91442.3.4 m.35198 sp TRI56_BOVIN 23.003 313 192 8 10 302 13 296 1.34E-15 81.3 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; F7E235 CHOYP_LOC100377010.15.16 m.63911 sp FAXC_XENTR 32.45 151 89 3 1 143 127 272 1.34E-24 100 FAXC_XENTR reviewed Failed axon connections homolog faxc Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 406 0 GO:0016021 0 0 0 PF17171;PF17172; F7J220 CHOYP_DMBT1.4.34 m.3798 sp SRCR1_PATPE 28.979 666 420 20 24 667 104 738 1.34E-69 256 SRCR1_PATPE reviewed Scavenger receptor cysteine-rich domain superfamily protein (ApSRCR1) SRCR1 Patiria pectinifera (Starfish) (Asterina pectinifera) 1128 innate immune response [GO:0045087]; phagocytosis [GO:0006909] GO:0005044; GO:0006909; GO:0016021; GO:0030659; GO:0045087 0 0 0 PF00530;PF00084; O60218 CHOYP_DVIR_GJ11267.1.1 m.29991 sp AK1BA_HUMAN 49.346 306 146 4 18 320 14 313 1.34E-103 309 AK1BA_HUMAN reviewed Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) AKR1B10 AKR1B11 Homo sapiens (Human) 316 cellular aldehyde metabolic process [GO:0006081]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202] GO:0001523; GO:0001758; GO:0004033; GO:0005764; GO:0005829; GO:0006081; GO:0007586; GO:0008202; GO:0016488; GO:0044597; GO:0044598; GO:0045550; GO:0047718; GO:0070062 0 0 cd06660; PF00248; O70165 CHOYP_BRAFLDRAFT_126820.1.1 m.20948 sp FCN1_MOUSE 49.39 164 71 5 114 272 116 272 1.34E-41 149 FCN1_MOUSE reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Mus musculus (Mouse) 334 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 secretion [GO:2000484]" GO:0001867; GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0046872; GO:0097367; GO:2000484 0 0 0 PF01391;PF00147; O70277 CHOYP_BRAFLDRAFT_82426.9.20 m.39428 sp TRIM3_RAT 21.643 499 311 20 74 552 115 553 1.34E-09 64.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88572 CHOYP_LRP6.5.6 m.51335 sp LRP6_MOUSE 32.075 265 170 4 26 288 327 583 1.34E-35 146 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; P04792 CHOYP_DPER_GL22446.1.1 m.52315 sp HSPB1_HUMAN 37.838 74 45 1 28 100 95 168 1.34E-11 61.2 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P04792 CHOYP_RNP1B.1.1 m.59893 sp HSPB1_HUMAN 37.838 74 45 1 28 100 95 168 1.34E-11 61.2 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P06734 CHOYP_FCER2.4.9 m.4478 sp FCER2_HUMAN 33.333 171 93 6 28 196 133 284 1.34E-23 98.6 FCER2_HUMAN reviewed Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] FCER2 CD23A CLEC4J FCE2 IGEBF Homo sapiens (Human) 321 Notch signaling pathway [GO:0007219]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0005178; GO:0005886; GO:0005887; GO:0007219; GO:0009897; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P07291 CHOYP_MLE.1.9 m.15462 sp MLE_ARGIR 73.885 157 40 1 1 157 1 156 1.34E-80 238 MLE_ARGIR reviewed "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 157 0 GO:0005509; GO:0016459 0 0 0 PF13499; P07291 CHOYP_MLE.2.9 m.21715 sp MLE_ARGIR 73.885 157 40 1 1 157 1 156 1.34E-80 238 MLE_ARGIR reviewed "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 157 0 GO:0005509; GO:0016459 0 0 0 PF13499; P07291 CHOYP_MLE.3.9 m.28782 sp MLE_ARGIR 73.885 157 40 1 1 157 1 156 1.34E-80 238 MLE_ARGIR reviewed "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 157 0 GO:0005509; GO:0016459 0 0 0 PF13499; P07291 CHOYP_MLE.7.9 m.44707 sp MLE_ARGIR 73.885 157 40 1 1 157 1 156 1.34E-80 238 MLE_ARGIR reviewed "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 157 0 GO:0005509; GO:0016459 0 0 0 PF13499; P07291 CHOYP_MLE.9.9 m.64367 sp MLE_ARGIR 73.885 157 40 1 1 157 1 156 1.34E-80 238 MLE_ARGIR reviewed "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 157 0 GO:0005509; GO:0016459 0 0 0 PF13499; P0CB96 CHOYP_NDUFS4.1.1 m.66417 sp NDUS4_PONPY 68.504 127 40 0 60 186 49 175 1.34E-62 194 NDUS4_PONPY reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit)" NDUFS4 Pongo pygmaeus (Bornean orangutan) 175 brain development [GO:0007420]; cAMP-mediated signaling [GO:0019933]; cellular respiration [GO:0045333]; electron transport chain [GO:0022900]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of fibroblast proliferation [GO:0048146]; reactive oxygen species metabolic process [GO:0072593]; response to cAMP [GO:0051591] GO:0005747; GO:0007420; GO:0016651; GO:0019933; GO:0022900; GO:0032981; GO:0045333; GO:0048146; GO:0051591; GO:0072593 0 0 0 PF04800; P10394 CHOYP_contig_012229 m.14049 sp POL4_DROME 23.797 395 248 13 9 382 55 417 1.34E-23 106 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P14866 CHOYP_LOC100120460.1.1 m.66688 sp HNRPL_HUMAN 48.78 164 81 2 1 163 422 583 1.34E-43 155 HNRPL_HUMAN reviewed Heterogeneous nuclear ribonucleoprotein L (hnRNP L) HNRNPL HNRPL P/OKcl.14 Homo sapiens (Human) 589 "gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]" GO:0000166; GO:0000381; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006396; GO:0010467; GO:0016020; GO:0030529; GO:0035770; GO:0044212; GO:0044822; GO:0045120; GO:0070062; GO:0097157 0 0 0 PF00076; P15800 CHOYP_LAMB1.1.1 m.58022 sp LAMB2_RAT 34.225 187 94 7 322 481 349 533 1.34E-19 96.3 LAMB2_RAT reviewed Laminin subunit beta-2 (Laminin chain B3) (Laminin-11 subunit beta) (Laminin-14 subunit beta) (Laminin-15 subunit beta) (Laminin-3 subunit beta) (Laminin-4 subunit beta) (Laminin-7 subunit beta) (Laminin-9 subunit beta) (S-laminin subunit beta) (S-LAM beta) Lamb2 Rattus norvegicus (Rat) 1801 cell adhesion [GO:0007155] GO:0005604; GO:0007155 0 0 0 PF00053;PF00055; P18489 CHOYP_TC00.1047053507811.60.1.1 m.54453 sp SYB_DROME 32.374 139 85 4 5 143 20 149 1.34E-14 69.3 SYB_DROME reviewed Synaptobrevin Syb CG12210 Drosophila melanogaster (Fruit fly) 152 "exocytosis [GO:0006887]; lumen formation, open tracheal system [GO:0035149]; neurotransmitter secretion [GO:0007269]; synaptic vesicle docking [GO:0016081]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" GO:0000149; GO:0005484; GO:0005886; GO:0006887; GO:0006906; GO:0007269; GO:0008021; GO:0016021; GO:0016081; GO:0016192; GO:0030054; GO:0030672; GO:0035149; GO:0043005 0 0 0 PF00957; P22105 CHOYP_MEG11.20.25 m.57880 sp TENX_HUMAN 32.127 221 91 20 205 389 191 388 1.34E-12 74.3 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P23198 CHOYP_ZGC_113176.1.1 m.37234 sp CBX3_MOUSE 43.284 67 34 3 359 422 12 77 1.34E-06 52 CBX3_MOUSE reviewed Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (M32) (Modifier 2 protein) Cbx3 Mus musculus (Mouse) 183 "covalent chromatin modification [GO:0016569]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of gene expression, epigenetic [GO:0045815]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000775; GO:0000779; GO:0000784; GO:0000785; GO:0000976; GO:0005634; GO:0005635; GO:0005654; GO:0005719; GO:0005720; GO:0005819; GO:0006351; GO:0010369; GO:0016569; GO:0019899; GO:0019904; GO:0031618; GO:0042802; GO:0045815; GO:0045892; GO:0048511; GO:1990226 0 0 0 PF00385;PF01393; P34457 CHOYP_LOC588385.2.2 m.64073 sp YMD3_CAEEL 31.405 242 147 3 89 329 1 224 1.34E-30 121 YMD3_CAEEL reviewed Putative uncharacterized transposon-derived protein F54H12.3 F54H12.3 Caenorhabditis elegans 286 DNA integration [GO:0015074] GO:0003676; GO:0015074 0 0 0 PF00665; P35802 CHOYP_LOC100874813.1.1 m.59637 sp GPM6A_MOUSE 29.572 257 156 8 7 252 22 264 1.34E-22 97.1 GPM6A_MOUSE reviewed Neuronal membrane glycoprotein M6-a (M6a) Gpm6a M6a Mus musculus (Mouse) 278 neural retina development [GO:0003407]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; positive regulation of filopodium assembly [GO:0051491]; stem cell differentiation [GO:0048863]; synapse assembly [GO:0007416] GO:0001764; GO:0003407; GO:0005262; GO:0005886; GO:0007416; GO:0016021; GO:0030175; GO:0043005; GO:0043025; GO:0043197; GO:0044295; GO:0048812; GO:0048863; GO:0051491; GO:0070062; GO:1903561 0 0 0 PF01275; P53563 CHOYP_LOC100377406.1.1 m.63355 sp B2CL1_RAT 30.921 152 96 3 135 278 82 232 1.34E-16 80.1 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; P53817 CHOYP_LRAT.1.1 m.53897 sp HRSL3_RAT 39.259 135 80 2 13 145 9 143 1.34E-20 89 HRSL3_RAT reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein) Pla2g16 H-rev107 Hrasls3 Hrev107 Rattus norvegicus (Rat) 160 lipid catabolic process [GO:0016042]; negative regulation of cell cycle [GO:0045786]; phospholipid biosynthetic process [GO:0008654] GO:0004623; GO:0005737; GO:0005783; GO:0008654; GO:0008970; GO:0016020; GO:0016021; GO:0016042; GO:0045786; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; P79782 CHOYP_TCF15.1.1 m.66678 sp TCF15_CHICK 51.37 146 54 4 13 156 24 154 1.34E-36 128 TCF15_CHICK reviewed Transcription factor 15 (TCF-15) (Paraxis) (Protein bHLH-EC2) TCF15 BHLHEC2 Gallus gallus (Chicken) 183 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275 0 0 0 PF00010; P85831 CHOYP_LOC658640.2.2 m.56941 sp PROH4_APIME 34.078 179 98 7 25 188 27 200 1.34E-20 87.8 PROH4_APIME reviewed Prohormone-4 [Cleaved into: Brain peptide IDLSRFYGHFNT; Brain peptide IDLSRFYGHFN; Brain peptide IDLSRFYGHF; Brain peptide DLSRFYGHFNT; Brain peptide DLSRFYGHFN; Brain peptide DLSRFYGHF] 0 Apis mellifera (Honeybee) 202 0 GO:0005576 0 0 0 PF00057; P90921 CHOYP_contig_026527 m.30227 sp ATPL1_CAEEL 34.146 82 54 0 54 135 30 111 1.34E-07 50.8 ATPL1_CAEEL reviewed "Probable ATP synthase subunit g 1, mitochondrial (ATPase subunit g 1)" asg-1 K07A12.3 Caenorhabditis elegans 131 ATP synthesis coupled proton transport [GO:0015986] GO:0000276; GO:0015078; GO:0015986 0 0 0 PF04718; P97314 CHOYP_SMP_087250.2.2 m.25167 sp CSRP2_MOUSE 49.718 177 84 2 11 182 10 186 1.34E-49 161 CSRP2_MOUSE reviewed Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (Double LIM protein 1) (DLP-1) Csrp2 Dlp1 Mus musculus (Mouse) 193 multicellular organism development [GO:0007275]; myoblast differentiation [GO:0045445] GO:0005634; GO:0005925; GO:0007275; GO:0008270; GO:0045445 0 0 0 PF00412; Q05695 CHOYP_L1CAM.2.2 m.49542 sp L1CAM_RAT 25.747 435 268 19 61 467 52 459 1.34E-27 123 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q12857 CHOYP_NFIA.1.1 m.54996 sp NFIA_HUMAN 48.347 484 173 15 1 478 7 419 1.34E-111 350 NFIA_HUMAN reviewed Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein) NFIA KIAA1439 Homo sapiens (Human) 509 "DNA replication [GO:0006260]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; synapse maturation [GO:0060074]; viral genome replication [GO:0019079]" GO:0000122; GO:0000978; GO:0001077; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0006260; GO:0006355; GO:0008134; GO:0019079; GO:0030054; GO:0045944; GO:0060074 0 0 0 PF00859;PF03165;PF10524; Q13459 CHOYP_MYO9.1.5 m.5801 sp MYO9B_HUMAN 41.268 710 351 11 1 654 478 1177 1.34E-152 514 MYO9B_HUMAN reviewed Unconventional myosin-IXb (Unconventional myosin-9b) MYO9B MYR5 Homo sapiens (Human) 2157 actin filament-based movement [GO:0030048]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; Roundabout signaling pathway [GO:0035385] GO:0000146; GO:0001726; GO:0003779; GO:0005096; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0005884; GO:0005938; GO:0007266; GO:0008270; GO:0015629; GO:0016020; GO:0016459; GO:0016887; GO:0017048; GO:0030027; GO:0030048; GO:0030898; GO:0035023; GO:0035385; GO:0043531; GO:0048471; GO:0048495; GO:0051056 0 0 0 PF00612;PF00063;PF00788;PF00620; Q15643 CHOYP_LOC100540539.1.1 m.14519 sp TRIPB_HUMAN 37.007 608 330 10 1700 2278 1394 1977 1.34E-96 352 TRIPB_HUMAN reviewed Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) 1979 protein targeting to Golgi [GO:0000042]; transcription from RNA polymerase II promoter [GO:0006366]; ventricular septum development [GO:0003281] GO:0000042; GO:0000139; GO:0002079; GO:0002081; GO:0003281; GO:0003713; GO:0005634; GO:0005794; GO:0005801; GO:0005856; GO:0006366; GO:0030133 0 0 0 0 Q24306 CHOYP_AAEL_AAEL009074.1.3 m.12087 sp DIAP1_DROME 47.727 88 46 0 59 146 218 305 1.34E-25 106 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q25145 CHOYP_TPM2.5.8 m.19714 sp TPM_HALRU 61.692 201 77 0 48 248 82 282 1.34E-70 221 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q28H54 CHOYP_CEPT1A.1.1 m.56785 sp CEPT1_XENTR 53.243 370 173 0 5 374 43 412 1.34E-136 399 CEPT1_XENTR reviewed Choline/ethanolaminephosphotransferase 1 (EC 2.7.8.1) (EC 2.7.8.2) cept1 TEgg057p14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 416 phosphatidylethanolamine biosynthetic process [GO:0006646] GO:0004142; GO:0004307; GO:0005789; GO:0006646; GO:0016021; GO:0031965; GO:0046872 PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.; PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2. 0 0 PF01066; Q2PFW9 CHOYP_LOC100182585.2.2 m.24665 sp NOVA1_MACFA 64.179 201 65 1 80 273 52 252 1.34E-79 261 NOVA1_MACFA reviewed RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Ventral neuron-specific protein 1) NOVA1 QflA-17531 QtsA-14227 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 483 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003723; GO:0005634 0 0 0 PF00013; Q3SX11 CHOYP_BRAFLDRAFT_60200.1.3 m.22201 sp NSA2_BOVIN 81.853 259 47 0 1 259 1 259 1.34E-162 454 NSA2_BOVIN reviewed Ribosome biogenesis protein NSA2 homolog (TGF-beta-inducible nuclear protein 1) NSA2 TINP1 Bos taurus (Bovine) 260 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0005730; GO:0030687; GO:0044822 0 0 0 PF01201; Q3ZBG9 CHOYP_PLS4.1.1 m.20326 sp PLS2_BOVIN 28.992 238 150 4 5 226 54 288 1.34E-29 115 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q4R5E1 CHOYP_BRAFLDRAFT_243769.1.1 m.19236 sp AKTIP_MACFA 47.876 259 126 3 35 288 37 291 1.34E-82 253 AKTIP_MACFA reviewed AKT-interacting protein (Fused toes protein homolog) AKTIP FTS QnpA-16528 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 292 apoptotic process [GO:0006915]; early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein transport [GO:0015031] GO:0005829; GO:0005886; GO:0006915; GO:0007032; GO:0007040; GO:0008333; GO:0015031; GO:0045022; GO:0070695 0 0 0 PF00179; Q4V842 CHOYP_GPTC4.2.2 m.26481 sp GPTC4_XENLA 52.02 198 90 4 5 197 13 210 1.34E-57 190 GPTC4_XENLA reviewed G patch domain-containing protein 4 gpatch4 gpatc4 Xenopus laevis (African clawed frog) 324 0 GO:0003676 0 0 0 PF01585; Q54KA7 CHOYP_contig_018254 m.21394 sp SECG_DICDI 36.139 404 254 4 27 426 69 472 1.34E-52 192 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q54P70 CHOYP_DICPUDRAFT_75027.1.3 m.24226 sp Y4757_DICDI 30.435 138 88 4 170 305 634 765 1.34E-11 70.9 Y4757_DICDI reviewed OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) 766 0 GO:0008234 0 0 0 PF02338; Q5M880 CHOYP_contig_054337 m.64833 sp PQLC1_RAT 50.584 257 117 2 76 332 7 253 1.34E-86 265 PQLC1_RAT reviewed PQ-loop repeat-containing protein 1 Pqlc1 Rattus norvegicus (Rat) 271 0 GO:0016021 0 0 0 PF04193; Q5R5H1 CHOYP_METK2.1.3 m.23175 sp METK2_PONAB 56.316 380 105 4 20 338 16 395 1.34E-149 429 METK2_PONAB reviewed S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) MAT2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 395 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0006556; GO:0006730; GO:0046872; GO:0048269 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q5RAP9 CHOYP_LOC100663668.1.1 m.66820 sp AT5G2_PONAB 66.346 104 30 1 19 122 42 140 1.34E-41 137 AT5G2_PONAB reviewed "ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase proteolipid P2) (ATPase protein 9) (ATPase subunit c)" ATP5G2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 141 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0008289; GO:0015078; GO:0015986; GO:0015991; GO:0016021; GO:0031966; GO:0045263 0 0 0 PF00137; Q5UNS9 CHOYP_CO5A2.1.1 m.28030 sp COLL7_MIMIV 50.968 155 74 1 42 194 81 235 1.34E-24 108 COLL7_MIMIV reviewed Collagen-like protein 7 MIMI_L669 Acanthamoeba polyphaga mimivirus (APMV) 1937 0 GO:0019012 0 0 0 PF01391; Q5ZKN5 CHOYP_FA53A.1.1 m.54245 sp FA53A_CHICK 29.714 350 167 14 104 411 106 418 1.34E-18 90.5 FA53A_CHICK reviewed Protein FAM53A (Dorsal neural-tube nuclear protein) FAM53A DNTNP RCJMB04_33c19 RCJMB04_9o15 Gallus gallus (Chicken) 418 protein import into nucleus [GO:0006606] GO:0005634; GO:0006606 0 0 0 PF15242; Q6PBU5 CHOYP_GRT1A.2.2 m.49214 sp GRT1A_DANRE 45.21 334 178 2 6 334 18 351 1.34E-108 323 GRT1A_DANRE reviewed Growth hormone-regulated TBC protein 1-A grtp1a grtp1 Danio rerio (Zebrafish) (Brachydanio rerio) 356 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF00566; Q6PJG9 CHOYP_LOC100378039.1.1 m.49570 sp LRFN4_HUMAN 32.308 260 163 4 87 340 65 317 1.34E-26 118 LRFN4_HUMAN reviewed Leucine-rich repeat and fibronectin type-III domain-containing protein 4 LRFN4 SALM3 Homo sapiens (Human) 635 axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268] GO:0005886; GO:0007268; GO:0007409; GO:0009986; GO:0016021 0 0 0 PF00041;PF07679;PF13855; Q6XPS3 CHOYP_TPTE.1.1 m.27201 sp TPTE2_HUMAN 42.653 490 259 8 85 565 46 522 1.34E-120 369 TPTE2_HUMAN reviewed "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)" TPTE2 TPIP Homo sapiens (Human) 522 phosphatidylinositol biosynthetic process [GO:0006661] GO:0000139; GO:0004725; GO:0005789; GO:0006661; GO:0008138; GO:0016021; GO:0016314; GO:0051800 0 0 0 PF00782;PF10409; Q86UC2 CHOYP_LOC100378839.1.1 m.21328 sp RSPH3_HUMAN 66.772 316 103 2 12 326 157 471 1.34E-128 384 RSPH3_HUMAN reviewed Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2) RSPH3 RSHL2 RSP3 Homo sapiens (Human) 560 0 0 0 0 0 PF06098; Q8IDX6 CHOYP_contig_005118 m.5858 sp RBP2A_PLAF7 29.412 119 76 2 135 245 2742 2860 1.34E-06 53.1 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8K1N2 CHOYP_LOC100368104.1.1 m.22554 sp PHLB2_MOUSE 34.519 675 346 18 887 1472 581 1248 1.34E-90 325 PHLB2_MOUSE reviewed Pleckstrin homology-like domain family B member 2 (Protein LL5-beta) Phldb2 Ll5b Mus musculus (Mouse) 1249 "establishment of protein localization [GO:0045184]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]" GO:0000226; GO:0005737; GO:0005886; GO:0005925; GO:0010470; GO:0010717; GO:0031252; GO:0045111; GO:0045180; GO:0045184; GO:0051497; GO:0051895; GO:0070507; GO:1903690; GO:1904261 0 0 0 PF00169; Q8TCT0 CHOYP_CERK.1.2 m.2488 sp CERK1_HUMAN 31.169 231 157 2 58 286 81 311 1.34E-34 139 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q8TCT0 CHOYP_CERK1.1.1 m.50970 sp CERK1_HUMAN 46.187 459 222 7 114 551 81 535 1.34E-140 421 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q91687 CHOYP_ITGA9.1.1 m.54401 sp ITA4_XENLA 25.983 1043 652 33 17 1010 35 1006 1.34E-67 249 ITA4_XENLA reviewed Integrin alpha-4 (Integrin alpha-IV) (VLA-4 subunit alpha) itga4 Xenopus laevis (African clawed frog) 1032 cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229] GO:0007155; GO:0007229; GO:0008305; GO:0046872 0 0 0 PF08441; Q921Q3 CHOYP_ALG1.1.1 m.40067 sp ALG1_MOUSE 51.62 432 202 3 30 455 33 463 1.34E-159 463 ALG1_MOUSE reviewed "Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142) (Asparagine-linked glycosylation protein 1 homolog) (Beta-1,4-mannosyltransferase) (GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase) (GDP-mannose-dolichol diphosphochitobiose mannosyltransferase)" Alg1 Mus musculus (Mouse) 482 protein glycosylation [GO:0006486] GO:0000030; GO:0004578; GO:0005783; GO:0005789; GO:0006486; GO:0016020; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00534; Q93134 CHOYP_GBLP.2.7 m.12820 sp GBLP_BIOGL 75 164 34 1 1 157 1 164 1.34E-84 254 GBLP_BIOGL reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) 0 Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) 316 0 0 0 0 0 PF00400; Q95XZ6 CHOYP_BRAFLDRAFT_277494.1.3 m.54115 sp LAAT1_CAEEL 33.779 299 182 6 25 322 16 299 1.34E-52 179 LAAT1_CAEEL reviewed Lysosomal amino acid transporter 1 laat-1 Y43H11AL.2 Caenorhabditis elegans 311 amino acid homeostasis [GO:0080144]; arginine transport [GO:0015809]; lysine transport [GO:0015819] GO:0005765; GO:0015181; GO:0015189; GO:0015809; GO:0015819; GO:0031301; GO:0080144 0 0 0 PF04193; Q95XZ6 CHOYP_LOAG_03597.1.1 m.9258 sp LAAT1_CAEEL 33.779 299 182 6 25 322 16 299 1.34E-52 179 LAAT1_CAEEL reviewed Lysosomal amino acid transporter 1 laat-1 Y43H11AL.2 Caenorhabditis elegans 311 amino acid homeostasis [GO:0080144]; arginine transport [GO:0015809]; lysine transport [GO:0015819] GO:0005765; GO:0015181; GO:0015189; GO:0015809; GO:0015819; GO:0031301; GO:0080144 0 0 0 PF04193; Q95ZJ1 CHOYP_GALT5.1.2 m.31636 sp GALT5_CAEEL 60.221 181 71 1 178 358 113 292 1.34E-68 229 GALT5_CAEEL reviewed Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans 626 protein O-linked glycosylation via threonine [GO:0018243] GO:0000139; GO:0004653; GO:0016021; GO:0018243; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q96NY8 CHOYP_BRAFLDRAFT_94327.1.1 m.57990 sp NECT4_HUMAN 23.077 312 194 13 26 323 40 319 1.34E-10 67.4 NECT4_HUMAN reviewed Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] NECTIN4 LNIR PRR4 PVRL4 Homo sapiens (Human) 510 adherens junction organization [GO:0034332]; cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0001618; GO:0004872; GO:0005102; GO:0005886; GO:0005887; GO:0005911; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0034332; GO:0042803; GO:0050839; GO:0070062 0 0 0 PF08205;PF07686; Q9C0D7 CHOYP_LOC101065570.1.1 m.53956 sp ZC12C_HUMAN 60.383 313 113 4 273 581 142 447 1.34E-114 382 ZC12C_HUMAN reviewed Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C) ZC3H12C KIAA1726 MCPIP3 Homo sapiens (Human) 883 0 GO:0004519; GO:0046872 0 0 0 PF11977; Q9CPT5 CHOYP_LOC100373289.1.2 m.7904 sp NOP16_MOUSE 41.317 167 91 3 29 194 6 166 1.34E-36 129 NOP16_MOUSE reviewed Nucleolar protein 16 Nop16 D13Wsu177e Mus musculus (Mouse) 178 ribosomal large subunit biogenesis [GO:0042273] GO:0005634; GO:0005730; GO:0042273; GO:0043231; GO:0044822 0 0 0 PF09420; Q9CQ46 CHOYP_RL4.4.6 m.37114 sp EFCB2_MOUSE 63.804 163 58 1 1 162 1 163 1.34E-74 223 EFCB2_MOUSE reviewed EF-hand calcium-binding domain-containing protein 2 Efcab2 Mus musculus (Mouse) 164 0 GO:0005509 0 0 0 0 Q9DCH4 CHOYP_NFRKB.1.1 m.18028 sp EIF3F_MOUSE 61.029 272 104 1 3 274 92 361 1.34E-123 359 EIF3F_MOUSE reviewed Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47) Eif3f Eif3s5 Mus musculus (Mouse) 361 formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; protein deubiquitination [GO:0016579]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0003743; GO:0004843; GO:0005852; GO:0006413; GO:0006446; GO:0016020; GO:0016282; GO:0016579; GO:0031369; GO:0033290; GO:0071541; GO:0075522 0 0 cd08064; PF01398;PF13012; Q9H1D0 CHOYP_LOC100077543.1.1 m.44114 sp TRPV6_HUMAN 27.876 226 117 11 86 304 119 305 1.34E-06 54.3 TRPV6_HUMAN reviewed Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) TRPV6 ECAC2 Homo sapiens (Human) 765 calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; regulation of calcium ion-dependent exocytosis [GO:0017158] GO:0005262; GO:0005516; GO:0005886; GO:0005887; GO:0006816; GO:0017158; GO:0070062; GO:0070588; GO:1990035 0 0 0 PF00023;PF12796;PF00520; Q9H7V2 CHOYP_SYNG1.1.1 m.44518 sp SYNG1_HUMAN 29.487 78 55 0 91 168 177 254 1.34E-06 50.1 SYNG1_HUMAN reviewed Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) SYNDIG1 C20orf39 TMEM90B Homo sapiens (Human) 258 intracellular protein transport [GO:0006886]; positive regulation of synapse assembly [GO:0051965]; response to biotic stimulus [GO:0009607]; synaptic vesicle clustering [GO:0097091] GO:0005887; GO:0006886; GO:0009607; GO:0014069; GO:0030054; GO:0031901; GO:0035254; GO:0042803; GO:0043197; GO:0043198; GO:0044297; GO:0045211; GO:0051965; GO:0060076; GO:0097091; GO:0098793 0 0 0 PF04505; Q9N0C5 CHOYP_KITM.1.2 m.30277 sp KITM_MACFA 49.77 217 107 2 51 267 43 257 1.34E-72 226 KITM_MACFA reviewed "Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)" TK2 QccE-13136 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 265 DNA biosynthetic process [GO:0071897] GO:0004797; GO:0005524; GO:0005739; GO:0071897 0 0 0 PF01712; Q9NRH2 CHOYP_LOC100742095.1.2 m.13089 sp SNRK_HUMAN 73.314 341 86 2 11 347 4 343 1.34E-176 535 SNRK_HUMAN reviewed SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) SNRK KIAA0096 SNFRK Homo sapiens (Human) 765 intracellular signal transduction [GO:0035556]; myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0030099; GO:0035556 0 0 0 PF00069; Q9R1R2 CHOYP_LOC100374741.29.83 m.32055 sp TRIM3_MOUSE 25.18 139 102 2 47 185 115 251 1.34E-06 54.7 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9TXQ1 CHOYP_BRAFLDRAFT_277055.1.2 m.3096 sp TNKS1_CAEEL 31.915 282 154 11 25 289 1646 1906 1.34E-29 122 TNKS1_CAEEL reviewed Tankyrase-like protein (EC 2.4.2.30) (Poly ADP-ribose metabolism enzyme 5) (Poly(ADP-ribose) polymerase pme-5) tank-1 pme-5 ZK1005.1 Caenorhabditis elegans 2276 cellular response to DNA damage stimulus [GO:0006974]; DNA ligation involved in DNA repair [GO:0051103]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lagging strand elongation [GO:0006273]; negative regulation of programmed cell death [GO:0043069]; protein ADP-ribosylation [GO:0006471]; response to gamma radiation [GO:0010332] GO:0003910; GO:0003950; GO:0005634; GO:0005694; GO:0005737; GO:0006273; GO:0006471; GO:0006974; GO:0008630; GO:0010332; GO:0043069; GO:0051103 0 0 0 PF12796;PF00644;PF02877;PF05406; Q9VWP4 CHOYP_SUOX.1.1 m.32255 sp SUOX_DROME 47.636 550 260 10 49 576 29 572 1.34E-179 522 SUOX_DROME reviewed "Probable sulfite oxidase, mitochondrial (EC 1.8.3.1)" CG7280 Drosophila melanogaster (Fruit fly) 573 nitrate assimilation [GO:0042128]; sulfur compound metabolic process [GO:0006790] GO:0005758; GO:0006790; GO:0008482; GO:0020037; GO:0030151; GO:0042128 PATHWAY: Energy metabolism; sulfur metabolism. 0 0 PF00173;PF03404;PF00174; Q9W0T1 CHOYP_BPTF.1.1 m.25244 sp NU301_DROME 43.223 546 269 13 1 514 1 537 1.34E-119 429 NU301_DROME reviewed Nucleosome-remodeling factor subunit NURF301 (Enhancer of bithorax) (Nucleosome-remodeling factor 215 kDa subunit) (NURF-215) E(bx) CG32346 CG7022 Nurf301 Drosophila melanogaster (Fruit fly) 2669 "chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; dendrite morphogenesis [GO:0048813]; ecdysone receptor-mediated signaling pathway [GO:0035076]; hemopoiesis [GO:0030097]; lateral inhibition [GO:0046331]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of innate immune response [GO:0045824]; negative regulation of JAK-STAT cascade [GO:0046426]; nucleosome mobilization [GO:0042766]; positive regulation of Notch signaling pathway [GO:0045747]; pupariation [GO:0035073]; regulation of gene expression [GO:0010468]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sensory perception of pain [GO:0019233]; spermatid differentiation [GO:0048515]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0006325; GO:0006338; GO:0006351; GO:0006357; GO:0007095; GO:0008270; GO:0010468; GO:0016569; GO:0016589; GO:0016922; GO:0019233; GO:0030097; GO:0035064; GO:0035073; GO:0035076; GO:0042766; GO:0045747; GO:0045824; GO:0046331; GO:0046426; GO:0048515; GO:0048813; GO:0070577 0 0 0 PF00439;PF02791;PF00628;PF15612; Q9XWD6 CHOYP_MEG11.10.25 m.40953 sp CED1_CAEEL 41.509 106 58 2 35 138 354 457 1.34E-14 75.1 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; Q9Z1T4 CHOYP_LOC100748006.1.2 m.19014 sp CNKR2_RAT 43.537 147 75 4 299 443 556 696 1.34E-30 130 CNKR2_RAT reviewed Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin) Cnksr2 Rattus norvegicus (Rat) 1032 regulation of signal transduction [GO:0009966] GO:0005794; GO:0009966; GO:0042802; GO:0043005; GO:0043025; GO:0045211; GO:0070062 0 0 0 PF10534;PF06663;PF00595;PF00169;PF00536; A0JM12 CHOYP_MEG10.87.91 m.64472 sp MEG10_XENTR 37.5 544 303 25 31 567 308 821 1.35E-70 249 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A1BQQ5 CHOYP_MR30.2.2 m.41897 sp MR30_CONMR 35.154 293 157 11 577 856 16 288 1.35E-37 146 MR30_CONMR reviewed Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp isoform 1/2/3) (Mr30-1/2) 0 Conus marmoreus (Marble cone) 289 0 GO:0005576 0 0 0 PF00188; A2RU49 CHOYP_DVIR_GJ17679.1.3 m.3874 sp HYKK_HUMAN 31.2 375 235 7 16 386 14 369 1.35E-56 192 HYKK_HUMAN reviewed Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) HYKK AGPHD1 Homo sapiens (Human) 373 lysine catabolic process [GO:0006554] GO:0005759; GO:0006554; GO:0047992 0 0 0 PF01636; A2T812 CHOYP_ZFP37.3.4 m.48467 sp ZN287_PONPY 39.303 201 115 4 171 368 554 750 1.35E-35 142 ZN287_PONPY reviewed Zinc finger protein 287 ZNF287 Pongo pygmaeus (Bornean orangutan) 754 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 cd07765; PF01352;PF02023;PF00096;PF13912; A4IF63 CHOYP_TRIM2.18.59 m.32449 sp TRIM2_BOVIN 34.951 103 62 3 33 132 631 731 1.35E-10 61.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NMZ7 CHOYP_BRAFLDRAFT_124935.1.1 m.65454 sp CO6A6_HUMAN 25.103 243 162 6 76 313 435 662 1.35E-18 90.9 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; B3EWZ6 CHOYP_LOC100120262.1.2 m.14779 sp MLRP2_ACRMI 38.983 177 97 7 68 241 891 1059 1.35E-29 122 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D2GXS7 CHOYP_contig_029491 m.33471 sp TRIM2_AILME 31.579 114 74 3 462 571 631 744 1.35E-07 58.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15973 CHOYP_LOC100370889.1.1 m.63215 sp OPSD1_MIZYE 31.068 309 182 8 26 311 52 352 1.35E-39 149 OPSD1_MIZYE reviewed "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 499 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0004930; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; O35598 CHOYP_LOC100745330.1.1 m.65802 sp ADA10_MOUSE 40.126 795 373 23 5 784 2 708 1.35E-173 522 ADA10_MOUSE reviewed Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c) Adam10 Kuz Madm Mus musculus (Mouse) 749 constitutive protein ectodomain proteolysis [GO:0051089]; epidermal growth factor receptor signaling pathway [GO:0007173]; in utero embryonic development [GO:0001701]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; nucleocytoplasmic transport [GO:0006913]; PMA-inducible membrane protein ectodomain proteolysis [GO:0051088]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; response to tumor necrosis factor [GO:0034612] GO:0001701; GO:0004175; GO:0004222; GO:0005634; GO:0005737; GO:0005794; GO:0005798; GO:0005802; GO:0005886; GO:0005925; GO:0006468; GO:0006509; GO:0006913; GO:0007162; GO:0007173; GO:0007219; GO:0007220; GO:0008237; GO:0008270; GO:0008284; GO:0009986; GO:0010820; GO:0014069; GO:0016020; GO:0016021; GO:0016485; GO:0019901; GO:0030307; GO:0030335; GO:0034612; GO:0042117; GO:0042169; GO:0042803; GO:0043231; GO:0051088; GO:0051089; GO:0070062; GO:0097038; GO:0097197 0 0 0 PF00200;PF01562; O43301 CHOYP_HSPA12A.23.27 m.61678 sp HS12A_HUMAN 29.542 633 378 13 14 593 56 673 1.35E-85 283 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75445 CHOYP_LOC100180399.1.1 m.11893 sp USH2A_HUMAN 29.11 292 198 4 347 630 4252 4542 1.35E-21 106 USH2A_HUMAN reviewed Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF02210;PF00055; O97758 CHOYP_BRAFLDRAFT_93411.3.3 m.54402 sp ZO1_CANLF 47.118 399 198 8 432 825 413 803 1.35E-95 348 ZO1_CANLF reviewed Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Canis lupus familiaris (Dog) (Canis familiaris) 1769 bicellular tight junction assembly [GO:0070830]; cellular response to calcium ion [GO:0071277] GO:0005886; GO:0005911; GO:0005921; GO:0005923; GO:0009986; GO:0031410; GO:0070830; GO:0071277 0 0 0 PF00625;PF00595;PF07653;PF00791; P05388 CHOYP_ISCW_ISCW007303.1.1 m.42265 sp RLA0_HUMAN 78.652 89 19 0 1 89 1 89 1.35E-45 152 RLA0_HUMAN reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Homo sapiens (Human) 317 "cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0002181; GO:0003735; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0030529; GO:0030687; GO:0036464; GO:0044822; GO:0070062; GO:0070180 0 0 0 PF00466; P0DMQ5 CHOYP_contig_047434 m.55941 sp INAM2_HUMAN 55.556 72 23 2 1 72 1 63 1.35E-18 78.6 INAM2_HUMAN reviewed Putative transmembrane protein INAFM2 (InaF-motif-containing protein 2) (Osteogenesis up-regulated transcript 1) INAFM2 LINC00984 OGU1 Homo sapiens (Human) 153 0 GO:0016021 0 0 0 PF15018; P10632 CHOYP_CP2CN.1.1 m.20209 sp CP2C8_HUMAN 38.241 489 301 1 1 488 1 489 1.35E-124 375 CP2C8_HUMAN reviewed Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) CYP2C8 Homo sapiens (Human) 490 drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; exogenous drug catabolic process [GO:0042738]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; oxidation-reduction process [GO:0055114]; oxidative demethylation [GO:0070989]; xenobiotic metabolic process [GO:0006805] GO:0004497; GO:0005506; GO:0005789; GO:0006082; GO:0006805; GO:0008392; GO:0008395; GO:0017144; GO:0019373; GO:0019825; GO:0020037; GO:0031090; GO:0034875; GO:0042738; GO:0055114; GO:0070330; GO:0070989; GO:0097267 0 0 0 PF00067; P11240 CHOYP_PHUM_PHUM477570.1.1 m.2101 sp COX5A_RAT 38.462 130 74 2 40 169 22 145 1.35E-23 93.6 COX5A_RAT reviewed "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" Cox5a Rattus norvegicus (Rat) 146 "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" GO:0004129; GO:0005751; GO:0006123; GO:0043209; GO:0046872; GO:0070062 0 0 cd00923; PF02284; P11369 CHOYP_LOC100561123.11.28 m.11413 sp LORF2_MOUSE 29.395 347 226 11 282 619 449 785 1.35E-31 137 LORF2_MOUSE reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) (Long interspersed element-1) (L1) (Retrovirus-related Pol polyprotein LINE-1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] Pol Gm17492 Mus musculus (Mouse) 1281 DNA recombination [GO:0006310] GO:0003964; GO:0004519; GO:0006310; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P16157 CHOYP_ANK2.4.8 m.35945 sp ANK1_HUMAN 31.948 770 513 3 319 1082 32 796 1.35E-110 383 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18433 CHOYP_PTPRT.40.45 m.61584 sp PTPRA_HUMAN 36.085 424 240 12 280 690 139 544 1.35E-66 238 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P23193 CHOYP_LOC100558815.1.1 m.30536 sp TCEA1_HUMAN 50.82 305 141 4 4 304 2 301 1.35E-100 300 TCEA1_HUMAN reviewed Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) TCEA1 GTF2S TFIIS Homo sapiens (Human) 301 "positive regulation of exoribonuclease activity [GO:1901919]; regulation of DNA-templated transcription, elongation [GO:0032784]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006283; GO:0006357; GO:0006366; GO:0006368; GO:0008270; GO:0032784; GO:1901919 0 0 0 PF08711;PF01096;PF07500; P23403 CHOYP_LRC57.1.1 m.50185 sp RS20_XENLA 90.598 117 9 2 4 118 3 119 1.35E-68 204 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P28827 CHOYP_PTPRM.9.15 m.46483 sp PTPRM_HUMAN 41.007 278 159 4 158 433 880 1154 1.35E-59 214 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P32250 CHOYP_LOC100375131.1.1 m.24092 sp LPAR6_CHICK 31.293 147 92 5 31 173 27 168 1.35E-07 56.2 LPAR6_CHICK reviewed Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) LPAR6 P2RY5 Gallus gallus (Chicken) 308 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; P40821 CHOYP_SELJ.1.1 m.21559 sp CRJ1C_TRICY 34.389 221 133 3 5 225 7 215 1.35E-34 129 CRJ1C_TRICY reviewed Crystallin J1C 0 Tripedalia cystophora (Jellyfish) 322 0 GO:0005212 0 0 0 PF03747; P56542 CHOYP_CRN6.1.1 m.31266 sp DNS2A_MOUSE 38.272 162 93 3 9 167 192 349 1.35E-33 124 DNS2A_MOUSE reviewed Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) Dnase2 Dnase2a Dnl2 Mus musculus (Mouse) 353 "apoptotic DNA fragmentation [GO:0006309]; DNA catabolic process [GO:0006308]; DNA catabolic process, endonucleolytic [GO:0000737]; erythrocyte differentiation [GO:0030218]" GO:0000737; GO:0004531; GO:0005764; GO:0006308; GO:0006309; GO:0030218; GO:0070062 0 0 0 PF03265; P62278 CHOYP_RS13.3.5 m.27303 sp RS13_RAT 88.667 150 17 0 17 166 1 150 1.35E-98 284 RS13_RAT reviewed 40S ribosomal protein S13 Rps13 Rattus norvegicus (Rat) 151 translation [GO:0006412] GO:0003735; GO:0005730; GO:0006412; GO:0022627; GO:0070181; GO:1990932 0 0 cd00353; PF08069;PF00312; Q01105 CHOYP_DUOX1.4.4 m.44613 sp SET_HUMAN 78.302 212 45 1 10 220 24 235 1.35E-117 341 SET_HUMAN reviewed Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) 290 "DNA replication [GO:0006260]; negative regulation of histone acetylation [GO:0035067]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of mRNA stability [GO:0043488]; viral process [GO:0016032]" GO:0003677; GO:0004864; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0006260; GO:0006334; GO:0006337; GO:0006913; GO:0008601; GO:0016032; GO:0035067; GO:0042393; GO:0043234; GO:0043488; GO:0043524; GO:0045892; GO:0048471 0 0 0 PF00956; Q01105 CHOYP_GBLP.7.7 m.66712 sp SET_HUMAN 78.302 212 45 1 10 220 24 235 1.35E-117 341 SET_HUMAN reviewed Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) 290 "DNA replication [GO:0006260]; negative regulation of histone acetylation [GO:0035067]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of mRNA stability [GO:0043488]; viral process [GO:0016032]" GO:0003677; GO:0004864; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0006260; GO:0006334; GO:0006337; GO:0006913; GO:0008601; GO:0016032; GO:0035067; GO:0042393; GO:0043234; GO:0043488; GO:0043524; GO:0045892; GO:0048471 0 0 0 PF00956; Q01262 CHOYP_LOC100375797.3.3 m.36578 sp HYUA_PSESN 30.89 191 126 4 1 185 167 357 1.35E-15 84.7 HYUA_PSESN reviewed Hydantoin utilization protein A (ORF2) hyuA Pseudomonas sp. (strain NS671) 690 cellular amino acid biosynthetic process [GO:0008652] GO:0008652; GO:0016787 0 0 0 PF05378;PF01968; Q03936 CHOYP_LOC100958782.1.1 m.32478 sp ZNF92_HUMAN 42.105 95 52 1 349 443 300 391 1.35E-19 94.7 ZNF92_HUMAN reviewed Zinc finger protein 92 (Zinc finger protein HTF12) ZNF92 Homo sapiens (Human) 586 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 cd07765; PF01352;PF00096;PF13912; Q06806 CHOYP_TIE1.1.1 m.13062 sp TIE1_MOUSE 43.607 305 163 3 488 787 827 1127 1.35E-77 275 TIE1_MOUSE reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) 1134 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; response to retinoic acid [GO:0032526]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001701; GO:0004714; GO:0005524; GO:0005886; GO:0016021; GO:0016525; GO:0030336; GO:0032526; GO:0045026 0 0 0 PF00041;PF00047;PF07714; Q0P467 CHOYP_LOC100698713.1.1 m.44275 sp RNKA_DANRE 45.205 73 39 1 35 107 27 98 1.35E-15 69.3 RNKA_DANRE reviewed Ribonuclease kappa-A (RNase K-A) (RNase kappa-A) (EC 3.1.-.-) rnaseka zgc:153350 Danio rerio (Zebrafish) (Brachydanio rerio) 101 rRNA transcription [GO:0009303] GO:0004521; GO:0009303; GO:0016021 0 0 0 0 Q12802 CHOYP_AKP13.4.5 m.63881 sp AKP13_HUMAN 29.73 962 537 34 706 1601 1790 2678 1.35E-90 333 AKP13_HUMAN reviewed A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) 2813 adrenergic receptor signaling pathway [GO:0071875]; adrenergic receptor signaling pathway involved in heart process [GO:0086023]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; nuclear export [GO:0051168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cardiac muscle hypertrophy [GO:0010611]; regulation of glucocorticoid mediated signaling pathway [GO:1900169]; regulation of protein kinase activity [GO:0045859]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004691; GO:0004871; GO:0005078; GO:0005085; GO:0005089; GO:0005634; GO:0005737; GO:0005829; GO:0005938; GO:0007186; GO:0007507; GO:0010611; GO:0016020; GO:0017048; GO:0032947; GO:0035025; GO:0035556; GO:0043065; GO:0043123; GO:0045859; GO:0046872; GO:0048471; GO:0051018; GO:0051056; GO:0051168; GO:0055007; GO:0060297; GO:0060348; GO:0071875; GO:0086023; GO:1900169 0 0 0 PF00169;PF00621;PF10522; Q15477 CHOYP_SKIV2L.1.4 m.2179 sp SKIV2_HUMAN 64.103 273 96 2 1 271 363 635 1.35E-117 370 SKIV2_HUMAN reviewed Helicase SKI2W (Ski2) (EC 3.6.4.-) (Helicase-like protein) (HLP) SKIV2L DDX13 SKI2W SKIV2 W Homo sapiens (Human) 1246 RNA catabolic process [GO:0006401] GO:0003723; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0006401; GO:0055087 0 0 0 PF00270;PF08148;PF00271;PF13234; Q18206 CHOYP_TSP_10831.1.1 m.47028 sp NAS36_CAEEL 27.692 390 238 17 103 474 118 481 1.35E-26 118 NAS36_CAEEL reviewed Zinc metalloproteinase nas-36 (EC 3.4.24.21) (Nematode astacin 36) nas-36 C26C6.3 Caenorhabditis elegans 617 "molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; multicellular organism development [GO:0007275]" GO:0004222; GO:0005576; GO:0007275; GO:0008270; GO:0018996 0 0 0 PF01400;PF00431;PF00090; Q23915 CHOYP_contig_011629 m.13368 sp KINX_DICDI 55.172 87 29 3 35 111 882 968 1.35E-07 55.5 KINX_DICDI reviewed Probable serine/threonine-protein kinase kinX (EC 2.7.11.1) kinX DDB_G0283391 Dictyostelium discoideum (Slime mold) 1094 0 GO:0004674; GO:0005524 0 0 0 PF07714; Q4KLZ1 CHOYP_LOC100692071.1.1 m.593 sp TM186_RAT 24.277 173 119 5 136 300 41 209 1.35E-08 57.4 TM186_RAT reviewed Transmembrane protein 186 Tmem186 Rattus norvegicus (Rat) 216 0 GO:0016021 0 0 0 0 Q5EA18 CHOYP_LOC588857.1.1 m.7902 sp CENPL_BOVIN 30.259 347 224 9 14 355 9 342 1.35E-39 146 CENPL_BOVIN reviewed Centromere protein L (CENP-L) CENPL Bos taurus (Bovine) 346 0 GO:0000775; GO:0005634 0 0 0 PF13092; Q5U508 CHOYP_TBCE.1.1 m.14005 sp TBCE_XENLA 44.253 522 276 8 38 556 13 522 1.35E-151 447 TBCE_XENLA reviewed Tubulin-specific chaperone E (Tubulin-folding cofactor E) tbce Xenopus laevis (African clawed frog) 522 post-chaperonin tubulin folding pathway [GO:0007023] GO:0005737; GO:0005856; GO:0007023 0 0 0 PF01302;PF14560; Q5ZLS2 CHOYP_EDC3.1.1 m.56918 sp EDC3_CHICK 41.772 553 263 14 1 542 1 505 1.35E-121 370 EDC3_CHICK reviewed Enhancer of mRNA-decapping protein 3 (YjeF domain-containing protein 1) EDC3 YJDC RCJMB04_5b1 Gallus gallus (Chicken) 506 cytoplasmic mRNA processing body assembly [GO:0033962]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087] GO:0000932; GO:0003729; GO:0031087; GO:0033962; GO:1990174 0 0 0 PF09532;PF12701;PF03853; Q6CEJ6 CHOYP_BRAFLDRAFT_109077.1.1 m.7494 sp CCR4_YARLI 29.296 355 203 11 72 396 341 677 1.35E-36 144 CCR4_YARLI reviewed Glucose-repressible alcohol dehydrogenase transcriptional effector (EC 3.1.13.4) (Carbon catabolite repressor protein 4) (Cytoplasmic deadenylase) CCR4 YALI0B15147g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) 705 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003723; GO:0004535; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF03372; Q6NRW0 CHOYP_MTBP.1.1 m.17026 sp MTBP_XENLA 25.415 783 478 30 97 827 125 853 1.35E-33 142 MTBP_XENLA reviewed Mdm2-binding protein mtbp Xenopus laevis (African clawed frog) 860 cell cycle arrest [GO:0007050] GO:0007050 0 0 0 PF14920;PF14919;PF14918; Q6PFX9 CHOYP_AASI_1435.13.35 m.35423 sp TNKS1_MOUSE 33.929 112 71 2 423 532 168 278 1.35E-08 62.4 TNKS1_MOUSE reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) 1320 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; Q803X0 CHOYP_SERC1.1.1 m.39708 sp SERC5_DANRE 38.855 489 256 8 4 485 5 457 1.35E-104 323 SERC5_DANRE reviewed Serine incorporator 5 serinc5 zgc:55396 Danio rerio (Zebrafish) (Brachydanio rerio) 460 defense response to virus [GO:0051607]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; myelination [GO:0042552]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; sphingolipid metabolic process [GO:0006665] GO:0005886; GO:0006658; GO:0006665; GO:0008654; GO:0009597; GO:0015194; GO:0016021; GO:0042552; GO:0045087; GO:0051607 0 0 0 PF03348; Q8AYK6 CHOYP_LOC100646268.1.1 m.11158 sp WEE1A_XENLA 47.862 491 213 12 134 594 94 571 1.35E-140 422 WEE1A_XENLA reviewed Wee1-like protein kinase 1-A (EC 2.7.10.2) (Zygotic wee1-like protein kinase 2) (XWee2) wee1-a wee2 Xenopus laevis (African clawed frog) 571 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0000287; GO:0004715; GO:0005524; GO:0005634; GO:0007067; GO:0051301 0 0 0 PF00069; Q8C0R9 CHOYP_BRAFLDRAFT_80919.1.1 m.62047 sp LRRD1_MOUSE 26 700 440 12 32 719 109 742 1.35E-51 197 LRRD1_MOUSE reviewed Leucine-rich repeat and death domain-containing protein 1 Lrrd1 Mus musculus (Mouse) 853 0 0 0 0 0 PF13855; Q8N9M1 CHOYP_CS047.1.1 m.7500 sp CS047_HUMAN 35.983 239 120 9 1 226 78 296 1.35E-24 107 CS047_HUMAN reviewed Uncharacterized protein C19orf47 C19orf47 Homo sapiens (Human) 422 0 GO:0005654 0 0 0 0 Q8R4V0 CHOYP_LOC100367908.1.2 m.1307 sp SGK3_RAT 50.769 130 62 2 35 162 33 162 1.35E-36 134 SGK3_RAT reviewed Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like) Sgk3 Cisk Sgkl Rattus norvegicus (Rat) 496 cellular sodium ion homeostasis [GO:0006883]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of sodium ion transport [GO:0010765]; positive regulation of transporter activity [GO:0032411]; regulation of apoptotic process [GO:0042981]; regulation of cell growth [GO:0001558]; regulation of cell proliferation [GO:0042127] GO:0001558; GO:0004674; GO:0005246; GO:0005524; GO:0005769; GO:0006883; GO:0010765; GO:0015459; GO:0016023; GO:0017080; GO:0017081; GO:0018105; GO:0032411; GO:0035091; GO:0035556; GO:0042127; GO:0042981; GO:0055037 0 0 0 PF00069;PF00433;PF00787; Q8TCT0 CHOYP_LOC101167008.1.2 m.48958 sp CERK1_HUMAN 28.413 271 189 2 32 297 50 320 1.35E-33 135 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q90610 CHOYP_LOC100877762.1.1 m.21428 sp NEO1_CHICK 29.883 599 363 14 1 556 129 713 1.35E-51 202 NEO1_CHICK reviewed Neogenin (Fragment) 0 Gallus gallus (Chicken) 1443 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; iron ion homeostasis [GO:0055072]; positive regulation of BMP signaling pathway [GO:0030513] GO:0004872; GO:0005887; GO:0007155; GO:0007411; GO:0030513; GO:0055072 0 0 0 PF00041;PF07679;PF13895;PF06583; Q90ZE4 CHOYP_BRAFLDRAFT_118108.1.1 m.58962 sp PSN2_DANRE 54.065 492 165 9 6 489 3 441 1.35E-161 468 PSN2_DANRE reviewed Presenilin-2 (PS-2) (Zf-PS2) (EC 3.4.23.-) (Pre2) psen2 Danio rerio (Zebrafish) (Brachydanio rerio) 441 beta-amyloid formation [GO:0034205]; brain development [GO:0007420]; calcium ion transport [GO:0006816]; intracellular signal transduction [GO:0035556]; melanocyte differentiation [GO:0030318]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of apoptotic process [GO:0043066]; neurogenesis [GO:0022008]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; protein processing [GO:0016485]; somite development [GO:0061053] GO:0000139; GO:0004175; GO:0004190; GO:0005634; GO:0005789; GO:0005887; GO:0005938; GO:0006509; GO:0006816; GO:0007219; GO:0007220; GO:0007420; GO:0016324; GO:0016485; GO:0022008; GO:0030018; GO:0030318; GO:0034205; GO:0035556; GO:0043025; GO:0043066; GO:0048471; GO:0061053 0 0 0 PF01080; Q96M20 CHOYP_LOC100376104.1.2 m.15205 sp CNBD2_HUMAN 24.532 481 271 15 221 661 70 498 1.35E-25 115 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96M20 CHOYP_LOC100893228.3.5 m.28159 sp CNBD2_HUMAN 26.721 247 159 6 206 441 59 294 1.35E-16 87.4 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96RW7 CHOYP_LOAG_01021.4.4 m.59610 sp HMCN1_HUMAN 27.2 250 158 11 225 469 3744 3974 1.35E-06 56.2 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99315 CHOYP_YG31B.3.3 m.27445 sp YG31B_YEAST 31.097 939 579 21 271 1198 564 1445 1.35E-117 405 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q99JB7 CHOYP_AMNLS.1.1 m.10427 sp AMNLS_MOUSE 35.443 79 41 3 2 74 236 310 1.35E-07 52.8 AMNLS_MOUSE reviewed Protein amnionless Amn Mus musculus (Mouse) 458 cobalamin transport [GO:0015889]; excretion [GO:0007588]; Golgi to plasma membrane protein transport [GO:0043001]; multicellular organism development [GO:0007275]; protein localization [GO:0008104]; receptor-mediated endocytosis [GO:0006898] GO:0005102; GO:0005615; GO:0005768; GO:0005905; GO:0006898; GO:0007275; GO:0007588; GO:0008104; GO:0015889; GO:0016021; GO:0016324; GO:0030139; GO:0043001; GO:0045177; GO:0070062 0 0 0 0 Q9D9B4 CHOYP_NEMVEDRAFT_V1G185153.1.1 m.41172 sp CJ011_MOUSE 33.784 148 96 1 6 151 12 159 1.35E-17 80.1 CJ011_MOUSE reviewed Leucine-rich repeat-containing protein C10orf11 homolog 0 Mus musculus (Mouse) 229 melanocyte differentiation [GO:0030318] GO:0030318 0 0 0 0 Q9DBY4 CHOYP_BRAFLDRAFT_101954.1.1 m.48821 sp TRIL_MOUSE 29.012 324 189 12 30 321 130 444 1.35E-17 87.4 TRIL_MOUSE reviewed TLR4 interactor with leucine rich repeats (Leucine-rich repeat-containing protein KIAA0644) Tril Kiaa0644 Mus musculus (Mouse) 809 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of cytokine production involved in immune response [GO:0002718]; toll-like receptor 4 signaling pathway [GO:0034142] GO:0001530; GO:0002718; GO:0006954; GO:0034142; GO:0045087; GO:0046696 0 0 0 PF13855;PF01463; Q9ESN6 CHOYP_BRAFLDRAFT_232970.5.5 m.53358 sp TRIM2_MOUSE 25.806 186 114 5 192 367 536 707 1.35E-08 60.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC100373444.65.79 m.60169 sp TRIM2_MOUSE 27.149 221 140 11 319 530 535 743 1.35E-08 61.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM2.4.59 m.7632 sp TRIM2_MOUSE 25.116 215 149 6 111 319 536 744 1.35E-09 62.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H0F5 CHOYP_RNF38.1.1 m.45050 sp RNF38_HUMAN 44.474 380 182 16 509 871 148 515 1.35E-59 215 RNF38_HUMAN reviewed E3 ubiquitin-protein ligase RNF38 (EC 6.3.2.-) (RING finger protein 38) RNF38 Homo sapiens (Human) 515 "male gonad development [GO:0008584]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]" GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0008270; GO:0008584; GO:0016567; GO:0016874; GO:0036126; GO:0043161; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q9H251 CHOYP_CDHR1.1.1 m.50464 sp CAD23_HUMAN 32.808 317 182 11 90 396 84 379 1.35E-29 125 CAD23_HUMAN reviewed Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) 3354 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0005509; GO:0005886; GO:0006816; GO:0007156; GO:0007601; GO:0007605; GO:0007626; GO:0016020; GO:0016021; GO:0016339; GO:0032420; GO:0045494; GO:0050896; GO:0050953; GO:0050957; GO:0051480; GO:0060122 0 0 0 PF00028; Q9HBL0 CHOYP_TENS3.3.4 m.52970 sp TENS1_HUMAN 46.448 366 170 5 8 348 6 370 1.35E-107 380 TENS1_HUMAN reviewed Tensin-1 TNS1 TNS Homo sapiens (Human) 1735 cell-substrate junction assembly [GO:0007044]; fibroblast migration [GO:0010761] GO:0005737; GO:0005856; GO:0005925; GO:0007044; GO:0009986; GO:0010761; GO:0044822 0 0 0 PF08416;PF10409;PF00017; Q9J516 CHOYP_AASI_1435.5.35 m.32345 sp V219_FOWPN 34.247 146 85 6 325 466 38 176 1.35E-07 58.2 V219_FOWPN reviewed Putative ankyrin repeat protein FPV219 FPV219 Fowlpox virus (strain NVSL) (FPV) 434 0 GO:0004190 0 0 0 PF00023;PF12796;PF09372; Q9QXA5 CHOYP_LSM4.2.3 m.44500 sp LSM4_MOUSE 85.057 87 6 2 1 87 15 94 1.35E-48 154 LSM4_MOUSE reviewed U6 snRNA-associated Sm-like protein LSm4 Lsm4 Mus musculus (Mouse) 137 cytoplasmic mRNA processing body assembly [GO:0033962]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of defense response to virus by host [GO:0002230]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; xenophagy [GO:0098792] GO:0000245; GO:0000387; GO:0000932; GO:0000956; GO:0002230; GO:0005654; GO:0005681; GO:0005688; GO:0005737; GO:0017070; GO:0033962; GO:0044822; GO:0097526; GO:0098779; GO:0098792 0 0 0 PF01423; Q9SZJ2 CHOYP_LOC100367312.3.13 m.3428 sp GRDP2_ARATH 40.071 282 153 5 836 1104 17 295 1.35E-56 214 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; Q9ULJ7 CHOYP_LOC753709.9.44 m.20595 sp ANR50_HUMAN 31.606 579 322 21 5 564 579 1102 1.35E-48 185 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VCD0 CHOYP_LOC100356898.1.1 m.59479 sp GATB_DROME 59.441 143 58 0 31 173 17 159 1.35E-56 189 GATB_DROME reviewed "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-)" CG5463 Drosophila melanogaster (Fruit fly) 516 glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543] GO:0005524; GO:0005739; GO:0030956; GO:0032543; GO:0050567; GO:0070681 0 0 0 PF02934;PF02637; Q9WUM3 CHOYP_SMP_012720.1.2 m.31152 sp COR1B_MOUSE 47.08 548 220 11 1 542 1 484 1.35E-169 492 COR1B_MOUSE reviewed Coronin-1B (Coronin-2) Coro1b Mus musculus (Mouse) 484 actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; endothelial cell chemotaxis [GO:0035767]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; positive regulation of lamellipodium morphogenesis [GO:2000394]; protein localization to cell leading edge [GO:1902463]; ruffle organization [GO:0031529]; wound healing [GO:0042060] GO:0001725; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005925; GO:0015629; GO:0016477; GO:0030027; GO:0030036; GO:0031252; GO:0031529; GO:0034316; GO:0035767; GO:0036120; GO:0042060; GO:0042802; GO:0048471; GO:0051015; GO:0051017; GO:0070062; GO:0071672; GO:0071933; GO:0071944; GO:0090135; GO:1902463; GO:2000394 0 0 0 PF08953;PF00400; A2AJ76 CHOYP_HMCN1.13.44 m.31483 sp HMCN2_MOUSE 25.043 583 343 26 22 548 3016 3560 1.36E-24 113 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A7X4K1 CHOYP_LOC100700188.1.1 m.30931 sp WAP1_PHIOL 40.909 88 41 2 67 151 46 125 1.36E-09 57 WAP1_PHIOL reviewed Waprin-Phi1 0 Philodryas olfersii (Green snake) 134 defense response to bacterium [GO:0042742] GO:0005576; GO:0030414; GO:0042742 0 0 0 PF00095; D2GXS7 CHOYP_LOC100369218.1.2 m.10486 sp TRIM2_AILME 23.552 259 168 10 269 521 508 742 1.36E-06 54.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O01578 CHOYP_SMP_099420.1.1 m.3127 sp MPC2_CAEEL 47.748 111 53 2 22 127 7 117 1.36E-32 114 MPC2_CAEEL reviewed Probable mitochondrial pyruvate carrier 2 (MPC2) F53F10.3 Caenorhabditis elegans 133 mitochondrial pyruvate transport [GO:0006850] GO:0005743; GO:0006850; GO:0016021 0 0 0 PF03650; O60218 CHOYP_PHUM_PHUM317840.2.2 m.36471 sp AK1BA_HUMAN 52.862 297 132 5 23 317 3 293 1.36E-96 291 AK1BA_HUMAN reviewed Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) AKR1B10 AKR1B11 Homo sapiens (Human) 316 cellular aldehyde metabolic process [GO:0006081]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202] GO:0001523; GO:0001758; GO:0004033; GO:0005764; GO:0005829; GO:0006081; GO:0007586; GO:0008202; GO:0016488; GO:0044597; GO:0044598; GO:0045550; GO:0047718; GO:0070062 0 0 cd06660; PF00248; O61463 CHOYP_RLA2.4.9 m.15346 sp RLA2_CRYST 65.152 66 23 0 1 66 1 66 1.36E-24 93.2 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O75095 CHOYP_PEAR1.10.16 m.42850 sp MEGF6_HUMAN 36.364 209 121 7 2 208 751 949 1.36E-24 107 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O89110 CHOYP_LOAG_08466.1.1 m.58955 sp CASP8_MOUSE 28.295 258 159 7 211 446 227 480 1.36E-20 97.4 CASP8_MOUSE reviewed Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) 480 activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cardiac muscle tissue development [GO:0048738]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; hepatocyte apoptotic process [GO:0097284]; macrophage differentiation [GO:0030225]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; neural tube formation [GO:0001841]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of thymocyte apoptotic process [GO:0070243]; response to tumor necrosis factor [GO:0034612]; TRAIL-activated apoptotic signaling pathway [GO:0036462] GO:0001525; GO:0001841; GO:0004175; GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005815; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0006919; GO:0007507; GO:0008233; GO:0008625; GO:0030225; GO:0030690; GO:0031264; GO:0031265; GO:0031625; GO:0034612; GO:0035877; GO:0036462; GO:0042802; GO:0043123; GO:0043124; GO:0045651; GO:0045862; GO:0046982; GO:0048738; GO:0051603; GO:0060546; GO:0070243; GO:0097110; GO:0097153; GO:0097190; GO:0097191; GO:0097194; GO:0097199; GO:0097202; GO:0097284; GO:0097342; GO:2001233; GO:2001238 0 0 0 PF01335; O95786 CHOYP_DDX58.4.9 m.15656 sp DDX58_HUMAN 40.909 88 49 1 172 256 241 328 1.36E-09 61.6 DDX58_HUMAN reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Homo sapiens (Human) 925 cytoplasmic pattern recognition receptor signaling pathway in response to virus [GO:0039528]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of type III interferon production [GO:0034344]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0034344; GO:0039528; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944; GO:0051091 0 0 0 PF16739;PF00270;PF00271;PF11648; P0C192 CHOYP_RXFP1.1.1 m.35952 sp LRC4B_MOUSE 26.523 279 135 8 32 268 44 294 1.36E-10 67.4 LRC4B_MOUSE reviewed Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3) Lrrc4b Lrig4 Mus musculus (Mouse) 709 cytokine-mediated signaling pathway [GO:0019221]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of synapse assembly [GO:0051965] GO:0004860; GO:0005102; GO:0005737; GO:0006469; GO:0016021; GO:0019221; GO:0030054; GO:0042734; GO:0044300; GO:0046426; GO:0051965 0 0 0 PF07679;PF13855; P0DH96 CHOYP_CALM.13.50 m.28874 sp CALM4_ARATH 39.583 144 86 1 16 159 1 143 1.36E-32 116 CALM4_ARATH reviewed Calmodulin-4 (CaM-4) CAM4 At1g66410 F28G11.13 T27F4.1 Arabidopsis thaliana (Mouse-ear cress) 149 0 GO:0005509 0 0 0 PF13499; P10155 CHOYP_RO60.6.6 m.62849 sp RO60_HUMAN 45.673 208 105 4 23 227 2 204 1.36E-55 189 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P16157 CHOYP_LOC100640442.7.10 m.53916 sp ANK1_HUMAN 28.304 855 502 31 649 1478 15 783 1.36E-46 188 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_LOC763941.2.4 m.36842 sp ANK1_HUMAN 33.086 538 349 2 146 673 222 758 1.36E-79 280 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P40199 CHOYP_FCHO2.1.1 m.46244 sp CEAM6_HUMAN 28.926 121 68 5 30 143 175 284 1.36E-07 53.5 CEAM6_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c) CEACAM6 NCA Homo sapiens (Human) 344 cell-cell signaling [GO:0007267]; leukocyte migration [GO:0050900]; signal transduction [GO:0007165] GO:0005615; GO:0005886; GO:0005887; GO:0007165; GO:0007267; GO:0031225; GO:0050900 0 0 0 PF13895;PF07686; P45842 CHOYP_NEMVEDRAFT_V1G237122.4.6 m.23176 sp RL34_AEDAL 70.909 110 31 1 1 110 1 109 1.36E-47 152 RL34_AEDAL reviewed 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01199; P50464 CHOYP_BRAFLDRAFT_275732.1.1 m.67062 sp UNC97_CAEEL 72.519 131 36 0 8 138 20 150 1.36E-68 213 UNC97_CAEEL reviewed LIM domain-containing protein unc-97 (PINCH homolog) (Uncoordinated protein 97) unc-97 F14D12.2 Caenorhabditis elegans 348 cell-cell junction organization [GO:0045216]; muscle organ development [GO:0007517]; sensory perception of mechanical stimulus [GO:0050954] GO:0005634; GO:0005654; GO:0005912; GO:0007517; GO:0008270; GO:0009925; GO:0017022; GO:0031430; GO:0045216; GO:0050954; GO:0055120 0 0 0 PF00412; P59999 CHOYP_ARPC4.2.2 m.35677 sp ARPC4_MOUSE 83.234 167 28 0 18 184 2 168 1.36E-101 292 ARPC4_MOUSE reviewed Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) Arpc4 Arc20 Mus musculus (Mouse) 168 actin filament polymerization [GO:0030041]; Arp2/3 complex-mediated actin nucleation [GO:0034314] GO:0005200; GO:0005737; GO:0005885; GO:0019899; GO:0030041; GO:0034314; GO:0042995; GO:0070062 0 0 0 PF05856; P62864 CHOYP_EF1B.1.7 m.26505 sp RS30_RAT 86.441 59 8 0 73 131 1 59 1.36E-21 84.3 RS30_RAT reviewed 40S ribosomal protein S30 Fau Rattus norvegicus (Rat) 59 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF04758; P69091 CHOYP_BRAFLDRAFT_79470.1.1 m.61035 sp RL18_ORENI 73.134 67 18 0 13 79 118 184 1.36E-30 109 RL18_ORENI reviewed 60S ribosomal protein L18 rpl18 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 188 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF17135; P70581 CHOYP_LOC100089326.1.1 m.19184 sp NUP58_RAT 42.661 436 177 14 209 613 192 585 1.36E-83 276 NUP58_RAT reviewed Nucleoporin p58/p45 (58 kDa nucleoporin) (Nucleoporin-like protein 1) Nup58 Nupl1 Rattus norvegicus (Rat) 585 mRNA transport [GO:0051028]; nucleocytoplasmic transport [GO:0006913]; protein heterooligomerization [GO:0051291]; protein heterotetramerization [GO:0051290]; protein heterotrimerization [GO:0070208]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of protein import into nucleus [GO:0042306] GO:0005487; GO:0005635; GO:0005643; GO:0006913; GO:0008139; GO:0015031; GO:0031965; GO:0042306; GO:0043234; GO:0051028; GO:0051260; GO:0051290; GO:0051291; GO:0070208 0 0 0 0 Q09PK2 CHOYP_LOC764850.7.8 m.36915 sp APRV1_MOUSE 27.184 103 74 1 481 582 193 295 1.36E-08 60.8 APRV1_MOUSE reviewed Retroviral-like aspartic protease 1 (EC 3.4.23.-) (Skin-specific retroviral-like aspartic protease) (SASPase) (Skin aspartic protease) (TPA-inducible aspartic proteinase-like protein) Asprv1 Sasp Taps Mus musculus (Mouse) 339 protein processing [GO:0016485]; skin development [GO:0043588] GO:0004190; GO:0016021; GO:0016485; GO:0043588 0 0 0 0 Q15262 CHOYP_PTPRK.20.20 m.65083 sp PTPRK_HUMAN 31.98 591 359 17 161 729 867 1436 1.36E-74 267 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q2TV84 CHOYP_TRPM8.4.5 m.63519 sp TRPM1_MOUSE 25.283 265 159 11 67 303 143 396 1.36E-06 55.1 TRPM1_MOUSE reviewed Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1) Trpm1 Ltrpc1 Mus musculus (Mouse) 1622 calcium ion transport into cytosol [GO:0060402]; cellular response to light stimulus [GO:0071482]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; protein tetramerization [GO:0051262]; retinal rod cell development [GO:0046548]; signal transduction [GO:0007165]; visual perception [GO:0007601] GO:0005261; GO:0005262; GO:0005622; GO:0005886; GO:0007165; GO:0007216; GO:0007601; GO:0016021; GO:0035841; GO:0046548; GO:0051262; GO:0060402; GO:0071482 0 0 0 PF00520;PF16519; Q2YDC9 CHOYP_BRAFLDRAFT_79292.2.2 m.52862 sp PDCD2_BOVIN 41.091 275 133 7 1 261 82 341 1.36E-66 213 PDCD2_BOVIN reviewed Programmed cell death protein 2 PDCD2 Bos taurus (Bovine) 344 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; regulation of hematopoietic progenitor cell differentiation [GO:1901532] GO:0003677; GO:0005634; GO:0005737; GO:0006915; GO:0006919; GO:0046872; GO:0070062; GO:1901532; GO:1902035 0 0 0 PF04194;PF01753; Q460N5 CHOYP_PARP14.14.22 m.52621 sp PAR14_HUMAN 22.538 1797 1151 59 575 2277 150 1799 1.36E-78 293 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q58588 CHOYP_BRAFLDRAFT_127093.2.3 m.18824 sp Y1187_METJA 25.294 340 193 10 13 341 5 294 1.36E-21 96.7 Y1187_METJA reviewed Uncharacterized protein MJ1187 (EC 3.2.2.-) MJ1187 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 301 0 GO:0016787 0 0 0 PF03747; Q58CQ9 CHOYP_VNN1.1.1 m.14514 sp VNN1_BOVIN 46.154 494 246 10 25 511 4 484 1.36E-141 421 VNN1_BOVIN reviewed Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Vascular non-inflammatory molecule 1) (Vanin-1) VNN1 Bos taurus (Bovine) 510 biotin metabolic process [GO:0006768]; central nervous system development [GO:0007417]; nitrogen compound metabolic process [GO:0006807]; pantothenate metabolic process [GO:0015939] GO:0005886; GO:0006768; GO:0006807; GO:0007417; GO:0015939; GO:0017159; GO:0031225 0 0 0 PF00795; Q5G267 CHOYP_BRAFLDRAFT_74849.1.1 m.65602 sp NETR_MACMU 46.617 266 131 5 29 288 280 540 1.36E-71 239 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5MYT7 CHOYP_BRAFLDRAFT_66572.3.3 m.56658 sp OAS3_RAT 31.25 320 190 6 78 369 797 1114 1.36E-37 147 OAS3_RAT reviewed 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) Oas3 Rattus norvegicus (Rat) 1137 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; response to virus [GO:0009615] GO:0001730; GO:0003725; GO:0005524; GO:0005634; GO:0005737; GO:0009615; GO:0045087; GO:0046872; GO:0051607 0 0 0 PF01909;PF10421; Q5U243 CHOYP_BRAFLDRAFT_88570.1.2 m.55232 sp CLIP3_XENLA 38.462 91 41 2 1426 1516 275 350 1.36E-07 59.7 CLIP3_XENLA reviewed CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) clip3 clipr59 Xenopus laevis (African clawed frog) 534 0 GO:0005795; GO:0005802; GO:0005886; GO:0010008; GO:0045121 0 0 0 PF12796;PF01302; Q61830 CHOYP_LOC100889936.1.1 m.53547 sp MRC1_MOUSE 28.042 1052 671 34 546 1554 422 1430 1.36E-95 343 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q66I24 CHOYP_ASSY.4.4 m.66788 sp ASSY_DANRE 71.978 182 51 0 1 182 21 202 1.36E-98 295 ASSY_DANRE reviewed Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) ass1 ass zgc:92051 Danio rerio (Zebrafish) (Brachydanio rerio) 414 arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; urea cycle [GO:0000050] GO:0000050; GO:0000053; GO:0004055; GO:0005524; GO:0005737; GO:0006526 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.; PATHWAY: Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. 0 cd01999; PF00764; Q6DJ83 CHOYP_BRAFLDRAFT_73442.1.1 m.25138 sp CADM2_XENTR 24.9 249 156 13 29 261 30 263 1.36E-07 55.5 CADM2_XENTR reviewed Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) cadm2 igsf4d Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 433 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0042803; GO:0050839 0 0 0 PF08205;PF07686; Q6GM06 CHOYP_NOC.1.1 m.63031 sp OTU6B_XENLA 52.083 144 68 1 1 143 144 287 1.36E-51 168 OTU6B_XENLA reviewed OTU domain-containing protein 6B (EC 3.4.19.12) otud6b Xenopus laevis (African clawed frog) 294 0 GO:0036459 0 0 0 PF02338; Q6INV3 CHOYP_LRC57.1.1 m.50182 sp LRC57_XENLA 56.356 236 103 0 1 236 1 236 1.36E-88 265 LRC57_XENLA reviewed Leucine-rich repeat-containing protein 57 lrrc57 Xenopus laevis (African clawed frog) 238 0 0 0 0 0 PF13855; Q6MG64 CHOYP_BRAFLDRAFT_63397.2.8 m.13835 sp VWA7_RAT 24.777 674 399 23 38 682 43 637 1.36E-31 137 VWA7_RAT reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) 892 0 GO:0005576 0 0 0 0 Q6NVL7 CHOYP_LOC100375204.2.2 m.21490 sp CHM2B_XENTR 60.952 210 77 3 1 207 4 211 1.36E-81 244 CHM2B_XENTR reviewed Charged multivesicular body protein 2b (Chromatin-modifying protein 2b) (CHMP2b) chmp2b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 214 protein transport [GO:0015031]; vacuolar transport [GO:0007034] GO:0005829; GO:0007034; GO:0015031; GO:0031902 0 0 0 PF03357; Q6ZMN7 CHOYP_PZRN4.1.1 m.57803 sp PZRN4_HUMAN 35.405 531 227 21 12 468 265 753 1.36E-57 216 PZRN4_HUMAN reviewed PDZ domain-containing RING finger protein 4 (Ligand of Numb protein X 4) (SEMACAP3-like protein) PDZRN4 LNX4 SEMCAP3L Homo sapiens (Human) 1036 0 GO:0004842; GO:0008270 0 0 0 PF00595; Q6ZMW2 CHOYP_BLF.1.1 m.65986 sp ZN782_HUMAN 51.429 105 51 0 42 146 590 694 1.36E-28 113 ZN782_HUMAN reviewed Zinc finger protein 782 ZNF782 Homo sapiens (Human) 699 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q6ZRF8 CHOYP_LOC100369014.9.9 m.53367 sp RN207_HUMAN 22.727 198 138 7 17 212 103 287 1.36E-07 58.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7T0L6 CHOYP_LOC100374550.1.1 m.46062 sp CCNF_XENLA 40.864 602 332 7 33 614 29 626 1.36E-145 448 CCNF_XENLA reviewed Cyclin-F ccnf Xenopus laevis (African clawed frog) 761 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of centrosome duplication [GO:0010826]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005634; GO:0005814; GO:0007067; GO:0010826; GO:0016567; GO:0019005; GO:0031146; GO:0051301 0 0 0 PF02984;PF00134;PF00646; Q7TSA6 CHOYP_BRAFLDRAFT_83553.1.1 m.11293 sp PRSR3_MOUSE 29.767 215 84 8 147 320 70 258 1.36E-06 55.5 PRSR3_MOUSE reviewed Proline and serine-rich protein 3 Proser3 Mus musculus (Mouse) 634 0 0 0 0 0 0 Q7Z2W4 CHOYP_LOC100370625.3.3 m.59992 sp ZCCHV_HUMAN 28.378 148 88 6 105 247 82 216 1.36E-10 65.5 ZCCHV_HUMAN reviewed Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) ZC3HAV1 ZC3HDC2 PRO1677 Homo sapiens (Human) 902 cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; regulation of defense response to virus by host [GO:0050691]; response to virus [GO:0009615]; suppression by virus of host molecular function [GO:0039507] GO:0003950; GO:0005634; GO:0005737; GO:0005764; GO:0005770; GO:0005794; GO:0005913; GO:0009615; GO:0032481; GO:0032727; GO:0032728; GO:0039507; GO:0043123; GO:0044822; GO:0045071; GO:0045087; GO:0046872; GO:0050691; GO:0051607; GO:0061014; GO:0071360; GO:0098641; GO:1900246 0 0 0 PF00644;PF02825; Q8BGZ3 CHOYP_ISCW_ISCW019533.1.1 m.7396 sp DCA12_MOUSE 46.731 413 188 9 39 428 49 452 1.36E-121 363 DCA12_MOUSE reviewed DDB1- and CUL4-associated factor 12 (WD repeat-containing protein 40A) Dcaf12 Kiaa1892 Wdr40a Mus musculus (Mouse) 453 protein ubiquitination [GO:0016567] GO:0005737; GO:0005813; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8CEI1 CHOYP_NEMVEDRAFT_V1G235656.1.1 m.19149 sp BOLA3_MOUSE 55.446 101 40 2 4 103 12 108 1.36E-31 110 BOLA3_MOUSE reviewed BolA-like protein 3 Bola3 Mus musculus (Mouse) 110 0 GO:0005576 0 0 0 PF01722; Q8IZJ3 CHOYP_CPAMD8.2.2 m.25540 sp CPMD8_HUMAN 30.286 175 107 6 35 198 951 1121 1.36E-11 70.1 CPMD8_HUMAN reviewed C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) 1885 0 GO:0004867; GO:0005615; GO:0005886 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF07648;PF12248;PF10569; Q8K0U4 CHOYP_LOC100207121.1.9 m.14550 sp HS12A_MOUSE 32.612 647 365 19 24 612 40 673 1.36E-100 323 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N0N9 CHOYP_ODH.1.2 m.1327 sp ODH_HALDH 54.975 402 177 2 6 404 4 404 1.36E-164 470 ODH_HALDH reviewed Opine dehydrogenase (EC 1.5.1.-) tadh Haliotis discus hannai (Japanese abalone) 405 0 GO:0008677; GO:0050662 0 0 0 PF02558;PF02317; Q8N0W4 CHOYP_NLGN4.4.4 m.62336 sp NLGNX_HUMAN 34.107 560 342 14 41 587 53 598 1.36E-96 317 NLGNX_HUMAN reviewed "Neuroligin-4, X-linked (Neuroligin X) (HNLX)" NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 Homo sapiens (Human) 816 adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; learning [GO:0007612]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625] GO:0003360; GO:0004872; GO:0005886; GO:0005887; GO:0007158; GO:0007612; GO:0009986; GO:0014069; GO:0016021; GO:0021549; GO:0030054; GO:0030182; GO:0030425; GO:0030534; GO:0031404; GO:0035176; GO:0035265; GO:0042043; GO:0042803; GO:0045202; GO:0045211; GO:0045216; GO:0050808; GO:0050839; GO:0052689; GO:0060076; GO:0071625; GO:0090394; GO:0097105; GO:0097110 0 0 0 PF00135; Q8VE97 CHOYP_SRSF4.5.6 m.41912 sp SRSF4_MOUSE 80.328 61 12 0 33 93 117 177 1.36E-29 116 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q96M20 CHOYP_LOC100180193.1.2 m.7969 sp CNBD2_HUMAN 24.576 236 166 5 122 349 63 294 1.36E-13 77.4 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q99946 CHOYP_LOC100379067.3.4 m.28409 sp PRRT1_HUMAN 50 76 38 0 62 137 219 294 1.36E-18 82.8 PRRT1_HUMAN reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) PRRT1 C6orf31 NG5 Homo sapiens (Human) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q99KJ8 CHOYP_DCTN2.1.1 m.1084 sp DCTN2_MOUSE 49.257 404 199 2 1 400 1 402 1.36E-123 366 DCTN2_MOUSE reviewed Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (Growth cone membrane protein 23-48K) (GMP23-48K) (p50 dynamitin) Dctn2 Mus musculus (Mouse) 402 cell proliferation [GO:0008283]; melanosome transport [GO:0032402]; microtubule-based process [GO:0007017]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; protein localization to centrosome [GO:0071539] GO:0000776; GO:0003774; GO:0005737; GO:0005813; GO:0005869; GO:0005874; GO:0007017; GO:0007052; GO:0007067; GO:0008283; GO:0016020; GO:0030286; GO:0030426; GO:0030507; GO:0031982; GO:0032402; GO:0070062; GO:0071539 0 0 0 0 Q9BQA9 CHOYP_LOC100631809.2.2 m.62574 sp CQ062_HUMAN 39.227 181 107 2 4 182 3 182 1.36E-37 131 CQ062_HUMAN reviewed Uncharacterized protein C17orf62 C17orf62 Homo sapiens (Human) 187 0 GO:0016021 0 0 0 PF15169; Q9ESN6 CHOYP_contig_024549 m.27912 sp TRIM2_MOUSE 27.957 186 106 6 60 233 534 703 1.36E-09 61.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NRA2 CHOYP_LOC100378615.1.2 m.25321 sp S17A5_HUMAN 34.146 328 177 3 190 517 27 315 1.36E-57 202 S17A5_HUMAN reviewed Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) 495 amino acid transport [GO:0006865]; anion transport [GO:0006820]; ion transport [GO:0006811]; sialic acid transport [GO:0015739] GO:0005351; GO:0005737; GO:0005765; GO:0005886; GO:0005887; GO:0006811; GO:0006820; GO:0006865; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0030054; GO:0030672 0 0 cd06174; PF07690; Q9QZI7 CHOYP_TSAP1.2.2 m.63952 sp TSAP1_RAT 33.846 130 80 2 1 124 157 286 1.36E-11 63.2 TSAP1_RAT reviewed tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) Trnau1ap Secp43 Trspap1 Rattus norvegicus (Rat) 287 selenocysteine incorporation [GO:0001514] GO:0000049; GO:0000166; GO:0001514; GO:0005634; GO:0005737 0 0 0 PF00076; Q9UJT9 CHOYP_LOC100643394.1.1 m.59700 sp FBXL7_HUMAN 34.579 107 57 2 29 127 113 214 1.36E-11 64.3 FBXL7_HUMAN reviewed F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) 491 cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000086; GO:0000151; GO:0004842; GO:0005737; GO:0005813; GO:0006511; GO:0007067; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q9UKJ5 CHOYP_LOC100366987.1.2 m.11319 sp CHIC2_HUMAN 69.065 139 43 0 30 168 27 165 1.36E-62 193 CHIC2_HUMAN reviewed Cysteine-rich hydrophobic domain-containing protein 2 (BrX-like translocated in leukemia) CHIC2 BTL Homo sapiens (Human) 165 Golgi to plasma membrane transport [GO:0006893] GO:0005798; GO:0005886; GO:0006893 0 0 0 PF10256; Q9VAC5 CHOYP_AAEL_AAEL003910.1.1 m.36530 sp ADA17_DROME 36.533 698 411 15 24 699 29 716 1.36E-144 443 ADA17_DROME reviewed ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) 732 membrane protein ectodomain proteolysis [GO:0006509] GO:0004222; GO:0006509; GO:0008270; GO:0016021 0 0 0 PF16698;PF00200;PF01562; Q9VCA8 CHOYP_TVAG_452290.1.1 m.64058 sp ANKHM_DROME 31.579 380 224 14 326 684 688 1052 1.36E-33 142 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; A2BD94 CHOYP_FBX31.1.1 m.13531 sp FB31B_XENLA 26.362 459 235 16 26 403 62 498 1.37E-28 120 FB31B_XENLA reviewed F-box only protein 31-B fbxo31-b Xenopus laevis (African clawed frog) 523 cellular response to DNA damage stimulus [GO:0006974]; mitotic G1 DNA damage checkpoint [GO:0031571]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0006974; GO:0008054; GO:0016567; GO:0019005; GO:0031146; GO:0031571 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; B3DIV9 CHOYP_LOC100372040.1.1 m.45699 sp KL40A_DANRE 29.412 561 341 8 44 574 19 554 1.37E-80 269 KL40A_DANRE reviewed Kelch-like protein 40a (Kelch repeat and BTB domain-containing protein 5a) klhl40a kbtbd5a Danio rerio (Zebrafish) (Brachydanio rerio) 612 muscle structure development [GO:0061061]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; protein ubiquitination [GO:0016567]; skeletal muscle fiber development [GO:0048741]; swimming [GO:0036268] GO:0016567; GO:0031397; GO:0031463; GO:0031672; GO:0031674; GO:0032435; GO:0036268; GO:0048741; GO:0061061 0 0 0 PF07707;PF00651;PF01344; B3EWY8 CHOYP_LOC101238350.1.1 m.23002 sp SAAR2_ACRMI 28.571 266 153 6 352 587 130 388 1.37E-26 115 SAAR2_ACRMI reviewed Skeletal aspartic acid-rich protein 2 (Fragment) 0 Acropora millepora (Staghorn coral) 390 0 GO:0016021 0 0 0 0 B6Q1K5 CHOYP_ISCW_ISCW022189.1.1 m.8228 sp STS1_TALMQ 28.662 157 106 5 124 275 66 221 1.37E-10 64.7 STS1_TALMQ reviewed Tethering factor for nuclear proteasome sts1 sts1 PMAA_027120 Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) 312 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [GO:0071630]; proteasome localization [GO:0031144]; protein transport [GO:0015031] GO:0005634; GO:0005737; GO:0015031; GO:0031144; GO:0071630 0 0 0 PF08559; E9Q6J5 CHOYP_LOC100373080.4.6 m.15046 sp BD1L1_MOUSE 54.808 104 47 0 12 115 50 153 1.37E-33 146 BD1L1_MOUSE reviewed Biorientation of chromosomes in cell division protein 1-like 1 Bod1l Kiaa1327 Mus musculus (Mouse) 3032 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] GO:0003677; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0031297 0 0 0 0 O14867 CHOYP_LOC100575377.8.10 m.40171 sp BACH1_HUMAN 28.205 117 84 0 7 123 11 127 1.37E-09 64.7 BACH1_HUMAN reviewed Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) 736 "DNA repair [GO:0006281]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]" GO:0000083; GO:0000117; GO:0000122; GO:0000980; GO:0001078; GO:0001205; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006281; GO:0006355; GO:0016567; GO:0020037; GO:0031463; GO:0061418 0 0 0 PF00651;PF03131; O42387 CHOYP_LOC100554367.1.1 m.11480 sp RS24_TAKRU 81.102 127 24 0 5 131 4 130 1.37E-72 215 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O55070 CHOYP_LOC100368897.1.2 m.12693 sp DNSL3_MOUSE 37.918 269 160 3 26 287 20 288 1.37E-60 202 DNSL3_MOUSE reviewed Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD) Dnase1l3 Mus musculus (Mouse) 310 apoptotic DNA fragmentation [GO:0006309]; programmed cell death involved in cell development [GO:0010623] GO:0003677; GO:0004519; GO:0004520; GO:0005634; GO:0006309; GO:0010623 0 0 0 PF03372; O60232 CHOYP_SSSCA1.2.2 m.48046 sp SSA27_HUMAN 46.078 204 92 4 2 202 10 198 1.37E-50 165 SSA27_HUMAN reviewed Sjoegren syndrome/scleroderma autoantigen 1 (Autoantigen p27) SSSCA1 Homo sapiens (Human) 199 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0007067; GO:0051301 0 0 0 PF06677; O73775 CHOYP_LOC100177897.1.1 m.23063 sp FBLN1_CHICK 42.927 205 107 8 25 223 352 552 1.37E-35 145 FBLN1_CHICK reviewed Fibulin-1 (FIBL-1) FBLN1 Gallus gallus (Chicken) 704 extracellular matrix organization [GO:0030198] GO:0005509; GO:0005578; GO:0016504; GO:0030198 0 0 0 PF01821;PF12662;PF07645; O75179 CHOYP_LOC581927.13.27 m.35501 sp ANR17_HUMAN 35.904 376 219 13 11 373 222 588 1.37E-52 191 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75521 CHOYP_BRAFLDRAFT_57395.1.1 m.9938 sp ECI2_HUMAN 53.908 371 166 3 32 401 24 390 1.37E-137 401 ECI2_HUMAN reviewed "Enoyl-CoA delta isomerase 2, mitochondrial (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)" ECI2 DRS1 HCA88 PECI Homo sapiens (Human) 394 cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062] GO:0000062; GO:0004165; GO:0005102; GO:0005654; GO:0005739; GO:0005782; GO:0006635; GO:0009062; GO:0016020; GO:0043231; GO:0044255 0 0 0 PF00887;PF00378; O95714 CHOYP_LOC100370069.4.14 m.34712 sp HERC2_HUMAN 30.822 146 75 4 147 290 1811 1932 1.37E-09 64.7 HERC2_HUMAN reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; intracellular protein transport [GO:0006886]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005743; GO:0005814; GO:0006303; GO:0006886; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016925; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; O97159 CHOYP_LOC100864311.1.1 m.40017 sp CHDM_DROME 74.436 266 49 4 33 296 1725 1973 1.37E-123 397 CHDM_DROME reviewed Chromodomain-helicase-DNA-binding protein Mi-2 homolog (EC 3.6.4.12) (ATP-dependent helicase Mi-2) (dMi-2) Mi-2 CG8103 Drosophila melanogaster (Fruit fly) 1982 "ATP-dependent chromatin remodeling [GO:0043044]; chromosome decondensation [GO:0051312]; chromosome organization [GO:0051276]; dendrite morphogenesis [GO:0048813]; muscle organ development [GO:0007517]; negative regulation of cohesin loading [GO:0071923]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome mobilization [GO:0042766]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003682; GO:0004003; GO:0004386; GO:0005524; GO:0005634; GO:0005700; GO:0005829; GO:0006351; GO:0006357; GO:0007283; GO:0007517; GO:0008270; GO:0016581; GO:0016887; GO:0031491; GO:0035327; GO:0042766; GO:0043044; GO:0045892; GO:0048813; GO:0051276; GO:0051312; GO:0070615; GO:0071923 0 0 0 PF08074;PF08073;PF00385;PF06461;PF06465;PF00271;PF00628;PF00176; P28575 CHOYP_LOC100375903.1.1 m.16819 sp IPP_MOUSE 25.98 612 387 20 9 590 8 583 1.37E-46 176 IPP_MOUSE reviewed Actin-binding protein IPP (Intracisternal A particle-promoted polypeptide) (IPP) (Murine IAP-promoted placenta-expressed protein) (Protein MIPP) Ipp Mipp Mus musculus (Mouse) 584 protein ubiquitination [GO:0016567] GO:0005737; GO:0005856; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; P32921 CHOYP_WARS.1.1 m.25088 sp SYWC_MOUSE 69.792 96 29 0 1 96 354 449 1.37E-42 148 SYWC_MOUSE reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" Wars Wrs Mus musculus (Mouse) 481 angiogenesis [GO:0001525]; regulation of angiogenesis [GO:0045765]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0001525; GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0006436; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P46023 CHOYP_GR101.2.3 m.40107 sp GR101_LYMST 64.286 364 127 2 1 362 740 1102 1.37E-166 498 GR101_LYMST reviewed G-protein coupled receptor GRL101 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 1115 0 GO:0005886; GO:0016021; GO:0016500 0 0 0 PF00001;PF00057;PF12799;PF13855; P62501 CHOYP_LOC100883123.1.1 m.704 sp T22D1_RAT 72.84 81 22 0 467 547 24 104 1.37E-29 117 T22D1_RAT reviewed TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Tsc22d1 Tgfb1i4 Tsc22 Rattus norvegicus (Rat) 143 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351 0 0 0 PF01166; P98203 CHOYP_CTND2.1.1 m.12206 sp ARVC_MOUSE 39.432 563 286 16 644 1183 343 873 1.37E-104 358 ARVC_MOUSE reviewed Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog Arvcf Mus musculus (Mouse) 962 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; multicellular organism development [GO:0007275]; single organismal cell-cell adhesion [GO:0016337] GO:0005634; GO:0005737; GO:0005886; GO:0007275; GO:0016337; GO:0016339 0 0 0 PF00514; Q08CH8 CHOYP_LOC100372774.2.2 m.66973 sp CYHR1_DANRE 64.957 117 39 2 34 148 59 175 1.37E-44 154 CYHR1_DANRE reviewed Cysteine and histidine-rich protein 1 cyhr1 zgc:153061 Danio rerio (Zebrafish) (Brachydanio rerio) 375 0 GO:0005737; GO:0008270 0 0 0 0 Q13310 CHOYP_LOC100370010.4.5 m.25254 sp PABP4_HUMAN 51.613 124 44 4 1 115 353 469 1.37E-27 108 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q14151 CHOYP_SAFB2.2.3 m.30765 sp SAFB2_HUMAN 33.996 956 491 29 18 924 22 886 1.37E-70 257 SAFB2_HUMAN reviewed Scaffold attachment factor B2 (SAF-B2) SAFB2 KIAA0138 Homo sapiens (Human) 953 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0042802; GO:0043231; GO:0044822; GO:0070062 0 0 0 PF00076;PF02037; Q1MSJ5 CHOYP_CSPP1.14.14 m.65008 sp CSPP1_HUMAN 33.517 725 374 23 756 1420 549 1225 1.37E-48 193 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q1WIM2 CHOYP_LOC100880785.1.1 m.4118 sp CADM2_RAT 31.496 127 76 2 4 129 6 122 1.37E-12 67 CADM2_RAT reviewed Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2) Cadm2 Igsf4d Necl3 Rattus norvegicus (Rat) 435 brain development [GO:0007420]; cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005737; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0007420; GO:0008037; GO:0030424; GO:0032809; GO:0042803; GO:0045202; GO:0050839 0 0 0 PF08205;PF07686; Q3TBT3 CHOYP_COX3.3.3 m.31129 sp STING_MOUSE 32.907 313 198 4 52 363 38 339 1.37E-47 168 STING_MOUSE reviewed Stimulator of interferon genes protein (mSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (MMITA) (Transmembrane protein 173) Tmem173 Eris Mita Mpys Sting Mus musculus (Mouse) 378 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0006915; GO:0008134; GO:0016021; GO:0019901; GO:0031625; GO:0032092; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042802; GO:0042803; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; Q3UHX0 CHOYP_NOL8.1.1 m.17469 sp NOL8_MOUSE 47.5 200 96 4 1 198 7 199 1.37E-47 187 NOL8_MOUSE reviewed Nucleolar protein 8 Nol8 Mus musculus (Mouse) 1147 DNA replication [GO:0006260]; positive regulation of cell growth [GO:0030307]; rRNA processing [GO:0006364] GO:0000166; GO:0005634; GO:0005730; GO:0005737; GO:0006260; GO:0006364; GO:0030307; GO:0044822 0 0 0 PF00076; Q4V885 CHOYP_BRAFLDRAFT_208160.2.2 m.5172 sp COL12_RAT 33.577 137 75 8 12 145 611 734 1.37E-12 68.6 COL12_RAT reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) (Nurse cell scavenger receptor 2) Colec12 Clp1 Nsr2 Rattus norvegicus (Rat) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; Q5SZD4 CHOYP_LOC101065647.2.2 m.10863 sp GLYL3_HUMAN 23.552 259 167 9 13 252 13 259 1.37E-13 72.8 GLYL3_HUMAN reviewed Glycine N-acyltransferase-like protein 3 (EC 2.3.1.-) GLYATL3 C6orf140 Homo sapiens (Human) 288 0 GO:0005739; GO:0047961 0 0 0 PF08444;PF06021; Q5ZIN1 CHOYP_RHO1.3.3 m.44337 sp NUDC_CHICK 54.545 341 144 4 2 338 8 341 1.37E-127 372 NUDC_CHICK reviewed Nuclear migration protein nudC (Nuclear distribution protein C homolog) NUDC RCJMB04_24m10 Gallus gallus (Chicken) 341 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005737; GO:0005874; GO:0007067; GO:0051301 0 0 0 PF04969;PF16273;PF14050; Q66KE3 CHOYP_ISCW_ISCW021476.1.1 m.29578 sp CPSF4_XENTR 56.14 285 108 4 1 285 1 268 1.37E-114 333 CPSF4_XENTR reviewed Cleavage and polyadenylation specificity factor subunit 4 cpsf4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 269 mRNA processing [GO:0006397] GO:0003723; GO:0005847; GO:0006397; GO:0008270 0 0 0 PF00098; Q68FR6 CHOYP_LOC100200942.1.1 m.20330 sp EF1G_RAT 46.939 392 177 10 1 374 1 379 1.37E-113 341 EF1G_RAT reviewed Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) Eef1g Rattus norvegicus (Rat) 437 glutathione metabolic process [GO:0006749]; response to virus [GO:0009615] GO:0003746; GO:0004364; GO:0005634; GO:0005737; GO:0005783; GO:0006749; GO:0009615; GO:0016020; GO:0070062 0 0 0 PF00647;PF00043;PF02798; Q6KEQ9 CHOYP_PCDH7.1.3 m.6236 sp PC11X_PIG 34.247 730 447 15 24 739 27 737 1.37E-110 372 PC11X_PIG reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) PCDH11X PCDH11 PCDHX Sus scrofa (Pig) 1117 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q6P0B1 CHOYP_CELF2.3.4 m.23131 sp CELF2_DANRE 55.229 545 151 16 14 521 26 514 1.37E-180 520 CELF2_DANRE reviewed CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (RNA-binding protein BRUNOL-3) celf2 cugbp2 etr3 Danio rerio (Zebrafish) (Brachydanio rerio) 514 mRNA processing [GO:0006397] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006397 0 0 0 PF00076; Q6PGL7 CHOYP_BRAFLDRAFT_118099.2.6 m.3049 sp FAM21_MOUSE 31.431 1139 538 43 10 1062 72 1053 1.37E-64 245 FAM21_MOUSE reviewed WASH complex subunit FAM21 Fam21 D6Wsu116e Kiaa0592 Mus musculus (Mouse) 1334 "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005546; GO:0005547; GO:0005730; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005886; GO:0010314; GO:0015031; GO:0031901; GO:0032266; GO:0042147; GO:0043231; GO:0043325; GO:0070273; GO:0071203; GO:0080025 0 0 0 PF15255; Q7Z2K6 CHOYP_ERMP1.1.1 m.24986 sp ERMP1_HUMAN 32.5 440 268 12 2 431 484 904 1.37E-68 237 ERMP1_HUMAN reviewed Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) ERMP1 FXNA KIAA1815 Homo sapiens (Human) 904 0 GO:0005789; GO:0008237; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF04389; Q80VI1 CHOYP_BRAFLDRAFT_85511.13.23 m.34114 sp TRI56_MOUSE 24.837 306 192 10 83 370 13 298 1.37E-15 84.3 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q874R4 CHOYP_BRAFLDRAFT_68885.1.1 m.60820 sp PFL3_SCHPO 39.446 289 108 16 63 313 458 717 1.37E-06 53.5 PFL3_SCHPO reviewed Putative cell agglutination protein pfl3 (Pombe flocculin 3) pfl3 SPBC947.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 973 cell adhesion [GO:0007155] GO:0005783; GO:0007155; GO:0010339 0 0 0 PF11763; Q8C6L5 CHOYP_NEMVEDRAFT_V1G218264.4.14 m.20301 sp CGAS_MOUSE 28.846 156 91 5 196 334 328 480 1.37E-08 61.2 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8C8R3 CHOYP_TVAG_020440.11.21 m.24804 sp ANK2_MOUSE 33.218 289 156 3 1 252 51 339 1.37E-43 160 ANK2_MOUSE reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) Ank2 Mus musculus (Mouse) 3898 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; cardiac muscle contraction [GO:0060048]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cation channel activity [GO:2001257]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of SA node cell action potential [GO:0098907]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; T-tubule organization [GO:0033292] GO:0002027; GO:0005622; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0006874; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014069; GO:0014704; GO:0015459; GO:0016324; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0048471; GO:0050821; GO:0051117; GO:0051924; GO:0051928; GO:0055117; GO:0060048; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086014; GO:0086015; GO:0086036; GO:0086066; GO:0086070; GO:0086091; GO:0098904; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001257; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q8CFW7 CHOYP_CC2D2A.2.2 m.44919 sp C2D2A_MOUSE 56.667 90 39 0 14 103 1100 1189 1.37E-33 125 C2D2A_MOUSE reviewed Coiled-coil and C2 domain-containing protein 2A Cc2d2a Mus musculus (Mouse) 1633 axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; motile cilium assembly [GO:0044458]; motile primary cilium assembly [GO:1903887]; neural tube closure [GO:0001843]; nonmotile primary cilium assembly [GO:0035058]; protein localization to ciliary transition zone [GO:1904491]; smoothened signaling pathway [GO:0007224] GO:0001843; GO:0005737; GO:0005856; GO:0007224; GO:0007368; GO:0007507; GO:0035058; GO:0035082; GO:0035869; GO:0036038; GO:0042384; GO:0043010; GO:0044458; GO:0060271; GO:1903887; GO:1904491; GO:1990403 0 0 0 PF00168;PF15625; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.28.34 m.57401 sp VWDE_HUMAN 25.077 646 366 29 5 584 7 600 1.37E-24 115 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N884 CHOYP_LOC100375194.4.7 m.34417 sp CGAS_HUMAN 29.53 149 87 6 265 396 354 501 1.37E-06 54.7 CGAS_HUMAN reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 C6orf150 Homo sapiens (Human) 522 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0032481; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8N9F8 CHOYP_LOC100535679.1.1 m.62124 sp ZN454_HUMAN 36.594 276 166 4 427 702 244 510 1.37E-48 182 ZN454_HUMAN reviewed Zinc finger protein 454 ZNF454 Homo sapiens (Human) 522 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q8VCD5 CHOYP_LOC100376367.1.1 m.31878 sp MED17_MOUSE 44.574 258 113 7 24 264 7 251 1.37E-60 205 MED17_MOUSE reviewed Mediator of RNA polymerase II transcription subunit 17 (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) Med17 Crsp6 Trap80 Mus musculus (Mouse) 649 "androgen receptor signaling pathway [GO:0030521]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; stem cell population maintenance [GO:0019827]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000151; GO:0001104; GO:0003712; GO:0003713; GO:0004872; GO:0005634; GO:0005654; GO:0005667; GO:0006357; GO:0006367; GO:0016020; GO:0016592; GO:0019827; GO:0030518; GO:0030521; GO:0045893; GO:0045944; GO:0046966; GO:0061630 0 0 0 PF10156; Q8VCW8 CHOYP_ACSF2.1.4 m.24818 sp ACSF2_MOUSE 25.989 177 109 8 6 174 31 193 1.37E-06 51.2 ACSF2_MOUSE reviewed "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" Acsf2 Mus musculus (Mouse) 615 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005739; GO:0006631; GO:0016874 0 0 0 PF00501;PF13193; Q91YD4 CHOYP_TRPM8.2.5 m.21801 sp TRPM2_MOUSE 23.667 300 176 8 508 775 606 884 1.37E-13 78.6 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q92747 CHOYP_ARC1A.1.1 m.56262 sp ARC1A_HUMAN 59.633 218 86 2 46 261 152 369 1.37E-86 265 ARC1A_HUMAN reviewed Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) ARPC1A SOP2L Homo sapiens (Human) 370 actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096] GO:0003779; GO:0005829; GO:0005885; GO:0015629; GO:0030036; GO:0034314; GO:0036195; GO:0038096; GO:0048013; GO:0051015; GO:0070062 0 0 0 PF00400; Q96A72 CHOYP_MGN2.1.1 m.9330 sp MGN2_HUMAN 93.243 148 10 0 13 160 1 148 1.37E-100 288 MGN2_HUMAN reviewed Protein mago nashi homolog 2 MAGOHB MAGOH2 Homo sapiens (Human) 148 "mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; RNA splicing [GO:0008380]" GO:0000184; GO:0006397; GO:0008380; GO:0035145; GO:0043025; GO:0044822; GO:0051028; GO:0071013 0 0 cd11295; PF02792; Q96B97 CHOYP_SH3KBP1.1.1 m.30545 sp SH3K1_HUMAN 32.357 683 365 22 1 607 1 662 1.37E-74 254 SH3K1_HUMAN reviewed SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) SH3KBP1 CIN85 Homo sapiens (Human) 665 apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; regulation of cell shape [GO:0008360] GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005925; GO:0006897; GO:0006915; GO:0007010; GO:0007267; GO:0008360; GO:0016477; GO:0030139; GO:0030659; GO:0042059; GO:0043005; GO:0045202 0 0 0 PF14604; Q96M20 CHOYP_LOC100377915.1.1 m.45438 sp CNBD2_HUMAN 24.941 425 290 10 286 702 99 502 1.37E-21 102 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96MM6 CHOYP_BRAFLDRAFT_208436.19.32 m.58839 sp HS12B_HUMAN 31.115 646 351 16 9 579 60 686 1.37E-100 322 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208436.22.32 m.59131 sp HS12B_HUMAN 34.231 631 348 14 9 579 61 684 1.37E-119 372 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BXM0 CHOYP_contig_033549 m.38196 sp PRAX_HUMAN 23.797 374 241 11 1 343 436 796 1.37E-11 69.3 PRAX_HUMAN reviewed Periaxin PRX KIAA1620 Homo sapiens (Human) 1461 axon ensheathment [GO:0008366]; nerve development [GO:0021675] GO:0005634; GO:0005737; GO:0005886; GO:0008366; GO:0021675; GO:0030054; GO:0043209 0 0 0 0 Q9DG68 CHOYP_RLA0.7.7 m.66732 sp RLA0_RANSY 72.444 225 62 0 1 225 1 225 1.37E-117 342 RLA0_RANSY reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) 315 ribosome biogenesis [GO:0042254] GO:0005840; GO:0042254 0 0 0 PF00466; Q9H9B4 CHOYP_SFXN1.1.1 m.27758 sp SFXN1_HUMAN 70.064 314 94 0 61 374 9 322 1.37E-159 453 SFXN1_HUMAN reviewed Sideroflexin-1 (Tricarboxylate carrier protein) (TCC) SFXN1 Homo sapiens (Human) 322 erythrocyte differentiation [GO:0030218]; iron ion homeostasis [GO:0055072]; iron ion transport [GO:0006826] GO:0005739; GO:0005743; GO:0006826; GO:0015075; GO:0016021; GO:0030218; GO:0055072 0 0 0 PF03820; Q9PTN2 CHOYP_HR96.1.1 m.27038 sp VDRA_DANRE 30.686 277 171 7 78 348 54 315 1.37E-28 122 VDRA_DANRE reviewed "Vitamin D3 receptor A (VDR-A) (1,25-dihydroxyvitamin D3 receptor A) (Nuclear receptor subfamily 1 group I member 1-A)" vdra nr1i1a vdr Danio rerio (Zebrafish) (Brachydanio rerio) 453 "calcium ion homeostasis [GO:0055074]; heart jogging [GO:0003146]; heart looping [GO:0001947]; ossification [GO:0001503]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001503; GO:0001947; GO:0003146; GO:0003707; GO:0004879; GO:0005499; GO:0005634; GO:0006351; GO:0006355; GO:0008134; GO:0008270; GO:0008434; GO:0043565; GO:0055074; GO:1902098; GO:1902121 0 0 0 PF00104;PF00105; Q9ULJ7 CHOYP_LOC100637643.1.1 m.58356 sp ANR50_HUMAN 31.18 356 238 2 811 1161 536 889 1.37E-44 180 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A4IF63 CHOYP_BRAFLDRAFT_87269.2.8 m.33013 sp TRIM2_BOVIN 33.019 106 67 3 5 107 627 731 1.38E-09 57.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NHC0 CHOYP_LOC100709493.2.2 m.59425 sp CAN8_HUMAN 35.404 483 248 22 56 491 40 505 1.38E-68 240 CAN8_HUMAN reviewed Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) CAPN8 NCL2 Homo sapiens (Human) 703 digestion [GO:0007586]; proteolysis [GO:0006508] GO:0004198; GO:0005509; GO:0005737; GO:0005794; GO:0006508; GO:0007586 0 0 0 PF01067;PF00648; B2RXR6 CHOYP_AAEL_AAEL014742.1.8 m.4799 sp ANR44_MOUSE 30.357 560 336 14 4 552 192 708 1.38E-56 208 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; B3EWZ6 CHOYP_NEMVEDRAFT_V1G239043.6.6 m.39570 sp MLRP2_ACRMI 26.739 1294 754 59 1339 2522 889 2098 1.38E-77 293 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O05389 CHOYP_LOC100869187.1.1 m.62275 sp YRBE_BACSU 30.473 338 220 4 5 339 3 328 1.38E-50 174 YRBE_BACSU reviewed Uncharacterized oxidoreductase YrbE (EC 1.-.-.-) yrbE BSU27770 Bacillus subtilis (strain 168) 341 oxidation-reduction process [GO:0055114] GO:0016491; GO:0055114 0 0 0 PF01408;PF02894; O14522 CHOYP_PTPRC.5.14 m.34957 sp PTPRT_HUMAN 37.705 244 148 3 166 406 878 1120 1.38E-48 181 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14867 CHOYP_LOC100575377.6.10 m.32031 sp BACH1_HUMAN 28.205 117 84 0 7 123 11 127 1.38E-09 65.1 BACH1_HUMAN reviewed Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) 736 "DNA repair [GO:0006281]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]" GO:0000083; GO:0000117; GO:0000122; GO:0000980; GO:0001078; GO:0001205; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006281; GO:0006355; GO:0016567; GO:0020037; GO:0031463; GO:0061418 0 0 0 PF00651;PF03131; O14974 CHOYP_LOC100114433.4.4 m.62718 sp MYPT1_HUMAN 60.49 286 113 0 12 297 2 287 1.38E-115 385 MYPT1_HUMAN reviewed Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) 1030 cellular response to drug [GO:0035690]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; negative regulation of catalytic activity [GO:0043086]; positive regulation of myosin-light-chain-phosphatase activity [GO:0035508]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of nucleocytoplasmic transport [GO:0046822] GO:0000086; GO:0000776; GO:0004721; GO:0004857; GO:0004871; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005925; GO:0006470; GO:0007067; GO:0015629; GO:0019208; GO:0019901; GO:0030018; GO:0030155; GO:0031672; GO:0035507; GO:0035508; GO:0035690; GO:0043086; GO:0043292; GO:0045944; GO:0046822; GO:0051297; GO:0071889; GO:0072357 0 0 0 PF12796;PF15898; O70277 CHOYP_BRAFLDRAFT_87312.2.4 m.20528 sp TRIM3_RAT 27.731 119 83 2 39 155 625 742 1.38E-07 53.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_87336.2.9 m.17215 sp TRIM3_RAT 25 152 110 3 28 176 593 743 1.38E-07 54.3 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_LOC100634041.2.3 m.39970 sp ANR17_HUMAN 38.308 201 116 5 4 200 511 707 1.38E-25 106 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_BRAFLDRAFT_69798.11.22 m.42042 sp TRIM3_HUMAN 23.443 273 178 12 239 494 486 744 1.38E-09 64.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O76041 CHOYP_NEB.1.2 m.1049 sp NEBL_HUMAN 34.969 163 100 3 1 162 698 855 1.38E-19 87.8 NEBL_HUMAN reviewed Nebulette (Actin-binding Z-disk protein) NEBL LNEBL Homo sapiens (Human) 1014 cardiac muscle thin filament assembly [GO:0071691] GO:0001725; GO:0005523; GO:0008092; GO:0008307; GO:0030018; GO:0031005; GO:0031674; GO:0051015; GO:0070062; GO:0071691 0 0 0 PF00880;PF14604; O95477 CHOYP_LOC100891184.1.1 m.18226 sp ABCA1_HUMAN 61.272 173 62 2 1 173 2057 2224 1.38E-65 221 ABCA1_HUMAN reviewed ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein) ABCA1 ABC1 CERP Homo sapiens (Human) 2261 "cellular response to cholesterol [GO:0071397]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; endosomal transport [GO:0016197]; G-protein coupled receptor signaling pathway [GO:0007186]; high-density lipoprotein particle assembly [GO:0034380]; interleukin-1 beta secretion [GO:0050702]; intracellular cholesterol transport [GO:0032367]; lipoprotein metabolic process [GO:0042157]; lysosome organization [GO:0007040]; negative regulation of cholesterol storage [GO:0010887]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; peptide secretion [GO:0002790]; phagocytosis, engulfment [GO:0006911]; phospholipid efflux [GO:0033700]; phospholipid homeostasis [GO:0055091]; phospholipid translocation [GO:0045332]; platelet dense granule organization [GO:0060155]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cholesterol efflux [GO:0010875]; protein lipidation [GO:0006497]; regulation of Cdc42 protein signal transduction [GO:0032489]; response to drug [GO:0042493]; response to laminar fluid shear stress [GO:0034616]; response to low-density lipoprotein particle [GO:0055098]; response to nutrient [GO:0007584]; reverse cholesterol transport [GO:0043691]" GO:0002790; GO:0005102; GO:0005524; GO:0005543; GO:0005548; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0006497; GO:0006911; GO:0007040; GO:0007186; GO:0007584; GO:0008203; GO:0008509; GO:0009897; GO:0010745; GO:0010875; GO:0010887; GO:0015485; GO:0016197; GO:0017127; GO:0019905; GO:0030139; GO:0030819; GO:0031267; GO:0032367; GO:0032489; GO:0033344; GO:0033700; GO:0034185; GO:0034186; GO:0034188; GO:0034364; GO:0034380; GO:0034616; GO:0042157; GO:0042493; GO:0042626; GO:0042632; GO:0043691; GO:0045121; GO:0045332; GO:0045335; GO:0048471; GO:0050702; GO:0051117; GO:0055091; GO:0055098; GO:0060155; GO:0071222; GO:0071300; GO:0071397 0 0 0 PF00005; O95490 CHOYP_LOC578280.1.1 m.42277 sp AGRL2_HUMAN 26.184 718 430 23 868 1518 470 1154 1.38E-63 243 AGRL2_HUMAN reviewed Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) ADGRL2 KIAA0786 LEC1 LPHH1 LPHN2 Homo sapiens (Human) 1459 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0004930; GO:0007166; GO:0007186; GO:0016021; GO:0016524; GO:0030246 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; P0C5E4 CHOYP_PTPRQ.6.8 m.45809 sp PTPRQ_MOUSE 29.288 379 214 17 44 382 1907 2271 1.38E-28 121 PTPRQ_MOUSE reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Mus musculus (Mouse) 2300 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598]; vestibular receptor cell morphogenesis [GO:0060116] GO:0002244; GO:0004725; GO:0016021; GO:0032421; GO:0042472; GO:0045598; GO:0046856; GO:0050885; GO:0050910; GO:0060116 0 0 0 PF00041;PF00102; P0C6B8 CHOYP_AAEL_AAEL008069.1.2 m.58164 sp SVEP1_RAT 29.22 551 288 19 28 543 932 1415 1.38E-38 156 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P10173 CHOYP_FUMH.1.2 m.30526 sp FUMH_PIG 75.524 143 35 0 1 143 324 466 1.38E-73 229 FUMH_PIG reviewed "Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)" FH Sus scrofa (Pig) 466 fumarate metabolic process [GO:0006106]; malate metabolic process [GO:0006108]; protein tetramerization [GO:0051262]; tricarboxylic acid cycle [GO:0006099] GO:0004333; GO:0005739; GO:0005829; GO:0006099; GO:0006106; GO:0006108; GO:0045239; GO:0051262 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1. 0 0 PF10415;PF00206; P14198 CHOYP_CAOG_08159.2.2 m.66119 sp AAC4_DICDI 34.132 167 95 5 52 210 519 678 1.38E-16 82.4 AAC4_DICDI reviewed AAC-rich mRNA clone AAC4 protein AAC4 DDB_G0267458 Dictyostelium discoideum (Slime mold) 678 0 GO:0016021 0 0 0 0 P14314 CHOYP_RS32.1.1 m.57158 sp GLU2B_HUMAN 41.331 496 276 4 86 568 14 507 1.38E-124 380 GLU2B_HUMAN reviewed Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) PRKCSH G19P1 Homo sapiens (Human) 528 intracellular signal transduction [GO:0035556]; N-glycan processing [GO:0006491]; protein folding [GO:0006457] GO:0005080; GO:0005509; GO:0005622; GO:0005783; GO:0005788; GO:0006457; GO:0006491; GO:0035556; GO:0044325; GO:0051219 PATHWAY: Glycan metabolism; N-glycan metabolism. 0 0 PF13202;PF12999;PF13015; P16273 CHOYP_TRIADDRAFT_29994.1.1 m.48948 sp PRPX_HORVU 38.009 221 123 4 55 261 12 232 1.38E-45 155 PRPX_HORVU reviewed Pathogen-related protein 0 Hordeum vulgare (Barley) 235 defense response [GO:0006952]; response to biotic stimulus [GO:0009607] GO:0006952; GO:0009607 0 0 0 0 P22451 CHOYP_RL5.4.4 m.63061 sp RL5_CHICK 80.335 239 47 0 1 239 1 239 1.38E-144 414 RL5_CHICK reviewed 60S ribosomal protein L5 RPL5 Gallus gallus (Chicken) 297 ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0005925; GO:0006364; GO:0006412; GO:0008097; GO:0016020; GO:0022625; GO:0044822; GO:0070062 0 0 0 PF14204;PF17144; P25291 CHOYP_LOC580618.1.1 m.24551 sp GP2_CANLF 33.858 127 73 5 29 150 32 152 1.38E-09 63.2 GP2_CANLF reviewed Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis lupus familiaris (Dog) (Canis familiaris) 509 0 GO:0005576; GO:0005886; GO:0031225 0 0 0 PF00100; P29691 CHOYP_LOC101242512.1.1 m.48605 sp EF2_CAEEL 81.132 159 21 1 1 150 1 159 1.38E-81 260 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P36241 CHOYP_LOC100180883.1.1 m.46612 sp RL19_DROME 70.635 126 37 0 1 126 73 198 1.38E-51 164 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P48316 CHOYP_RL40.5.7 m.38937 sp GA45A_MOUSE 36.792 106 61 3 37 136 25 130 1.38E-10 60.1 GA45A_MOUSE reviewed Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) Gadd45a Ddit1 Gadd45 Mus musculus (Mouse) 165 activation of MAPKKK activity [GO:0000185]; cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; centrosome cycle [GO:0007098]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle arrest [GO:0071850]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of cell cycle [GO:0051726]; signal transduction in response to DNA damage [GO:0042770] GO:0000086; GO:0000185; GO:0001047; GO:0005634; GO:0005654; GO:0005737; GO:0006469; GO:0007098; GO:0042770; GO:0043065; GO:0046330; GO:0051726; GO:0071260; GO:0071479; GO:0071850; GO:1900745; GO:2000379 0 0 0 PF01248; P62925 CHOYP_IF5A.1.1 m.22700 sp IF5A_SPOFR 67.763 152 48 1 8 158 3 154 1.38E-72 218 IF5A_SPOFR reviewed Eukaryotic translation initiation factor 5A (eIF-5A) eIF-5A eIF5A Spodoptera frugiperda (Fall armyworm) 160 positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational frameshifting [GO:0006452] GO:0003746; GO:0005737; GO:0006452; GO:0043022; GO:0045901; GO:0045905 0 0 0 PF01287; P98161 CHOYP_BRAFLDRAFT_92052.1.1 m.42123 sp PKD1_HUMAN 22.791 645 401 21 290 906 959 1534 1.38E-24 115 PKD1_HUMAN reviewed Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein) PKD1 Homo sapiens (Human) 4303 anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-independent cell-matrix adhesion [GO:0007161]; calcium ion transmembrane transport [GO:0070588]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell cycle arrest [GO:0007050]; cell-matrix adhesion [GO:0007160]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of cell polarity [GO:0030010]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; JAK-STAT cascade [GO:0007259]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; neural tube development [GO:0021915]; nitrogen compound metabolic process [GO:0006807]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein export from nucleus [GO:0006611]; regulation of cell adhesion [GO:0030155]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; single organismal cell-cell adhesion [GO:0016337]; skin development [GO:0043588]; spinal cord development [GO:0021510] GO:0000139; GO:0001502; GO:0001701; GO:0001822; GO:0001889; GO:0001892; GO:0002133; GO:0005262; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005929; GO:0006611; GO:0006807; GO:0007050; GO:0007156; GO:0007160; GO:0007161; GO:0007204; GO:0007259; GO:0007507; GO:0009653; GO:0009986; GO:0016021; GO:0016323; GO:0016328; GO:0016337; GO:0018105; GO:0019901; GO:0019904; GO:0021510; GO:0021915; GO:0030010; GO:0030155; GO:0030246; GO:0030660; GO:0031512; GO:0031659; GO:0032092; GO:0034405; GO:0036303; GO:0042994; GO:0043588; GO:0044325; GO:0045944; GO:0048565; GO:0048754; GO:0048806; GO:0050982; GO:0051216; GO:0060170; GO:0060236; GO:0060428; GO:0060674; GO:0061136; GO:0070062; GO:0070588; GO:0072164; GO:0072177; GO:0072205; GO:0072218; GO:0072237; GO:0072287; GO:0072372 0 0 0 PF00059;PF13855;PF00801;PF08016;PF01477;PF02010;PF01822; Q01765 CHOYP_EF-1A.1.9 m.5617 sp EF1A_PODCU 75.49 102 25 0 7 108 360 461 1.38E-48 163 EF1A_PODCU reviewed Elongation factor 1-alpha (EF-1-alpha) TEF Podospora curvicolla 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q02391 CHOYP_GSLG1.2.3 m.42966 sp GSLG1_CHICK 43.655 197 99 3 93 278 74 269 1.38E-46 170 GSLG1_CHICK reviewed Golgi apparatus protein 1 (Cysteine-rich fibroblast growth factor receptor) GLG1 CFR Gallus gallus (Chicken) 1142 0 GO:0000139; GO:0016021; GO:0017134 0 0 0 PF00839; Q02395 CHOYP_LOC590080.1.1 m.48636 sp MTF2_MOUSE 52.038 319 147 4 275 589 46 362 1.38E-120 379 MTF2_MOUSE reviewed Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (mPCl2) (Zinc-regulated factor 1) (ZiRF1) Mtf2 Pcl2 Mus musculus (Mouse) 593 covalent chromatin modification [GO:0016569]; negative regulation of histone H3-K27 methylation [GO:0061086]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of histone H3-K27 methylation [GO:0061087]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; segment specification [GO:0007379]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827] GO:0000122; GO:0003677; GO:0005634; GO:0005737; GO:0007379; GO:0008270; GO:0016569; GO:0019827; GO:0035064; GO:0045944; GO:0048863; GO:0061086; GO:0061087 0 0 0 PF14061;PF00628; Q04831 CHOYP_GLNA.5.5 m.20141 sp GLNA_PANAR 66.842 190 63 0 1 190 1 190 1.38E-93 287 GLNA_PANAR reviewed Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) 0 Panulirus argus (Caribbean spiny lobster) (Palinurus argus) 361 glutamine biosynthetic process [GO:0006542] GO:0004356; GO:0005524; GO:0005737; GO:0006542 0 0 0 PF00120;PF03951; Q12955 CHOYP_TVAG_123950.21.31 m.47705 sp ANK3_HUMAN 34.884 301 192 1 1 301 128 424 1.38E-51 187 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q24292 CHOYP_DSIM_GD22944.1.1 m.16027 sp DS_DROME 30.204 245 165 3 171 414 1802 2041 1.38E-26 116 DS_DROME reviewed Protein dachsous (Adherin) ds CG17941 Drosophila melanogaster (Fruit fly) 3503 "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell morphogenesis involved in differentiation [GO:0000904]; cell proliferation [GO:0008283]; equator specification [GO:0045317]; establishment of cell polarity [GO:0030010]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; eye morphogenesis [GO:0048592]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing morphogenesis [GO:0007476]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; ommatidial rotation [GO:0016318]; peptide cross-linking [GO:0018149]; regulation of establishment of planar polarity [GO:0090175]; regulation of tube length, open tracheal system [GO:0035159]; single organismal cell-cell adhesion [GO:0016337]; wing disc pattern formation [GO:0035222]" GO:0000904; GO:0001736; GO:0001737; GO:0004871; GO:0004872; GO:0005509; GO:0005887; GO:0007156; GO:0007157; GO:0007164; GO:0007476; GO:0007480; GO:0008283; GO:0016021; GO:0016318; GO:0016337; GO:0016339; GO:0018149; GO:0030010; GO:0035159; GO:0035222; GO:0042067; GO:0044331; GO:0045198; GO:0045296; GO:0045317; GO:0048592; GO:0050839; GO:0090175; GO:0090176 0 0 0 PF00028; Q24K15 CHOYP_LOC100641657.1.1 m.62126 sp ANGP4_BOVIN 43.182 220 116 5 90 306 283 496 1.38E-55 190 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q291A0 CHOYP_DVIR_GJ20612.1.1 m.14542 sp RM41_DROPS 48.438 64 33 0 80 143 74 137 1.38E-15 72.8 RM41_DROPS reviewed "39S ribosomal protein L41, mitochondrial (L41mt) (MRP-L41)" mRpL41 GA11937 Drosophila pseudoobscura pseudoobscura (Fruit fly) 166 translation [GO:0006412] GO:0003735; GO:0005762; GO:0006412; GO:0030529 0 0 0 PF09809; Q2TAD9 CHOYP_LOC100647659.1.1 m.41848 sp CYR1B_XENLA 50.617 162 78 1 1 160 203 364 1.38E-56 184 CYR1B_XENLA reviewed Cysteine and histidine-rich protein 1-B cyhr1-b Xenopus laevis (African clawed frog) 365 0 GO:0005737; GO:0008270 0 0 0 0 Q2YGT9 CHOYP_SHEP.1.1 m.27991 sp RL6_PIG 62.366 186 66 2 9 193 102 284 1.38E-72 223 RL6_PIG reviewed 60S ribosomal protein L6 RPL6 Sus scrofa (Pig) 284 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; Q3T100 CHOYP_LOC588493.1.1 m.39545 sp MGST3_BOVIN 48.905 137 67 1 55 188 1 137 1.38E-39 135 MGST3_BOVIN reviewed Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) MGST3 Bos taurus (Bovine) 152 0 GO:0004364; GO:0004602; GO:0005635; GO:0005783; GO:0005789; GO:0016021; GO:0031090; GO:0070062 0 0 0 PF01124; Q3YEC7 CHOYP_RBEL1.1.1 m.174 sp RABL6_HUMAN 46.154 507 213 9 1 481 2 474 1.38E-133 417 RABL6_HUMAN reviewed Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1) RABL6 C9orf86 PARF Homo sapiens (Human) 729 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005634; GO:0005737; GO:0007264 0 0 0 PF00071; Q3ZCB2 CHOYP_NEMVEDRAFT_V1G205075.3.4 m.37984 sp PLAC8_BOVIN 36.585 123 61 5 87 203 2 113 1.38E-11 62.4 PLAC8_BOVIN reviewed Placenta-specific gene 8 protein PLAC8 Bos taurus (Bovine) 116 brown fat cell differentiation [GO:0050873]; defense response to bacterium [GO:0042742]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cold [GO:0009409] GO:0003682; GO:0008284; GO:0009409; GO:0040015; GO:0042742; GO:0043066; GO:0045944; GO:0050873 0 0 0 PF04749; Q460N5 CHOYP_PAR15.6.6 m.62825 sp PAR14_HUMAN 28.989 376 230 10 42 396 1019 1378 1.38E-32 139 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4T2X8 CHOYP_LOC100368820.1.1 m.12090 sp NIP7_TETNG 72.626 179 49 0 1 179 1 179 1.38E-103 298 NIP7_TETNG reviewed 60S ribosome subunit biogenesis protein NIP7 homolog nip7 GSTENG00008117001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 180 ribosome assembly [GO:0042255] GO:0003723; GO:0005730; GO:0042255 0 0 0 PF03657; Q569C3 CHOYP_LOC100366443.1.1 m.16535 sp UBP1_RAT 39.303 201 107 6 541 732 406 600 1.38E-32 139 UBP1_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) Usp1 Rattus norvegicus (Rat) 784 DNA repair [GO:0006281]; monoubiquitinated protein deubiquitination [GO:0035520]; protein deubiquitination [GO:0016579]; regulation of DNA repair [GO:0006282]; response to UV [GO:0009411]; skeletal system development [GO:0001501]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001501; GO:0004843; GO:0005634; GO:0006281; GO:0006282; GO:0006511; GO:0009411; GO:0016579; GO:0035520 0 0 0 PF00443; Q5EA25 CHOYP_LOC100888140.1.1 m.52604 sp SRPX2_BOVIN 30.159 189 126 5 76 263 84 267 1.38E-16 82 SRPX2_BOVIN reviewed Sushi repeat-containing protein SRPX2 SRPX2 Bos taurus (Bovine) 465 angiogenesis [GO:0001525]; cell motility [GO:0048870]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphorylation [GO:0042325]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005102; GO:0005615; GO:0005737; GO:0009986; GO:0015630; GO:0016337; GO:0030054; GO:0036458; GO:0042325; GO:0042802; GO:0048870; GO:0051965; GO:0060076; GO:0090050; GO:0097060 0 0 0 PF13778;PF02494;PF00084; Q5U5M8 CHOYP_ISCW_ISCW004420.2.8 m.5707 sp BL1S3_MOUSE 28.814 177 106 5 17 182 13 180 1.38E-08 55.5 BL1S3_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) (Reduced pigmentation protein) Bloc1s3 Blos3 Rp Mus musculus (Mouse) 195 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to drug [GO:0042493]; secretion of lysosomal enzymes [GO:0033299] GO:0001654; GO:0005737; GO:0005829; GO:0007596; GO:0008089; GO:0008320; GO:0016197; GO:0030133; GO:0030168; GO:0031083; GO:0031175; GO:0032402; GO:0032438; GO:0032816; GO:0033299; GO:0035646; GO:0042493; GO:0043473; GO:0048066; GO:0048490; GO:0060155; GO:1904115 0 0 0 PF15753; Q5UR67 CHOYP_LOC100638431.8.10 m.58430 sp RIBX_MIMIV 38.272 162 89 3 321 471 6 167 1.38E-25 105 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5UR67 CHOYP_LOC100638431.9.10 m.58653 sp RIBX_MIMIV 35.758 165 95 3 64 217 3 167 1.38E-24 99.8 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5XI67 CHOYP_FBX40.1.2 m.7370 sp FBX30_RAT 49.242 132 65 1 80 211 8 137 1.38E-35 140 FBX30_RAT reviewed F-box only protein 30 Fbxo30 Rattus norvegicus (Rat) 742 0 GO:0008270; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15966;PF15965; Q5ZIJ9 CHOYP_LOC100374277.1.3 m.16275 sp MIB2_CHICK 35.692 636 372 10 1 623 1 612 1.38E-130 409 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q60649 CHOYP_LOC100091505.1.1 m.64542 sp CLPB_MOUSE 45.745 94 45 2 1 88 571 664 1.38E-20 88.2 CLPB_MOUSE reviewed Caseinolytic peptidase B protein homolog (EC 3.6.1.3) (Suppressor of potassium transport defect 3) Clpb Skd3 Mus musculus (Mouse) 677 cellular response to heat [GO:0034605] GO:0005524; GO:0005739; GO:0016887; GO:0034605 0 0 0 PF07724;PF12796;PF10431; Q6AXS5 CHOYP_LOC100212542.1.1 m.22050 sp PAIRB_RAT 39.073 151 63 6 184 310 188 333 1.38E-09 62.4 PAIRB_RAT reviewed "Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (RDA288) (SERPINE1 mRNA-binding protein 1) [Cleaved into: Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processed]" Serbp1 Pairbp1 Rda288 Rattus norvegicus (Rat) 407 regulation of apoptotic process [GO:0042981] GO:0003730; GO:0005634; GO:0005737; GO:0005886; GO:0042981; GO:0048471; GO:0070062 0 0 0 PF04774;PF16174; Q6AYU1 CHOYP_ISCW_ISCW000087.1.1 m.5834 sp MO4L1_RAT 63.478 115 39 2 2 115 189 301 1.38E-45 152 MO4L1_RAT reviewed Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Transcription factor-like protein MRG15) Morf4l1 Rattus norvegicus (Rat) 323 "cell proliferation [GO:0008283]; chromatin modification [GO:0016568]; chromatin remodeling [GO:0006338]; chromatin silencing [GO:0006342]; double-strand break repair via homologous recombination [GO:0000724]; histone deacetylation [GO:0016575]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; regulation of growth [GO:0040008]; transcription, DNA-templated [GO:0006351]" GO:0000724; GO:0003682; GO:0006338; GO:0006342; GO:0006351; GO:0008283; GO:0016568; GO:0016575; GO:0016580; GO:0035267; GO:0040008; GO:0043967; GO:0043968 0 0 0 PF05712;PF11717; Q6AZ28 CHOYP_PIAS2.1.1 m.11880 sp PIAS2_RAT 51.527 491 196 9 8 464 1 483 1.38E-158 471 PIAS2_RAT reviewed E3 SUMO-protein ligase PIAS2 (EC 6.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting-zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) Pias2 Miz1 Piasx Rattus norvegicus (Rat) 572 "androgen receptor signaling pathway [GO:0030521]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of transcription, DNA-templated [GO:0045893]; protein sumoylation [GO:0016925]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of transcription, DNA-templated [GO:0006355]; response to organic substance [GO:0010033]; response to testosterone [GO:0033574]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007283; GO:0008270; GO:0010033; GO:0016605; GO:0016607; GO:0016874; GO:0016925; GO:0019789; GO:0019904; GO:0030331; GO:0030521; GO:0033574; GO:0035259; GO:0045893; GO:0050681; GO:0050775; GO:0060765 PATHWAY: Protein modification; protein sumoylation. 0 0 PF14324;PF02891; Q6GQN8 CHOYP_MECR.1.1 m.6989 sp MECR_DANRE 49.598 373 178 5 14 378 7 377 1.38E-121 359 MECR_DANRE reviewed "Trans-2-enoyl-CoA reductase, mitochondrial (EC 1.3.1.38)" mecr zgc:110153 Danio rerio (Zebrafish) (Brachydanio rerio) 377 fatty acid biosynthetic process [GO:0006633]; pronephric nephron tubule development [GO:0039020] GO:0005739; GO:0006633; GO:0008270; GO:0019166; GO:0039020 0 0 0 PF08240;PF00107; Q6P298 CHOYP_NUBP1.1.1 m.65721 sp NUBP1_DANRE 71.536 267 76 0 1 267 54 320 1.38E-152 431 NUBP1_DANRE reviewed Cytosolic Fe-S cluster assembly factor nubp1 (Nucleotide-binding protein 1) (NBP 1) nubp1 zgc:92138 Danio rerio (Zebrafish) (Brachydanio rerio) 321 iron-sulfur cluster assembly [GO:0016226] GO:0005524; GO:0005829; GO:0016226; GO:0046872; GO:0051536; GO:0051539 0 0 cd02037; 0 Q6P298 CHOYP_NUBP1.1.1 m.65722 sp NUBP1_DANRE 71.536 267 76 0 1 267 54 320 1.38E-152 431 NUBP1_DANRE reviewed Cytosolic Fe-S cluster assembly factor nubp1 (Nucleotide-binding protein 1) (NBP 1) nubp1 zgc:92138 Danio rerio (Zebrafish) (Brachydanio rerio) 321 iron-sulfur cluster assembly [GO:0016226] GO:0005524; GO:0005829; GO:0016226; GO:0046872; GO:0051536; GO:0051539 0 0 cd02037; 0 Q6P3Z3 CHOYP_BRAFLDRAFT_65518.1.1 m.29803 sp THAP4_MOUSE 45.455 165 81 3 7 162 403 567 1.38E-43 154 THAP4_MOUSE reviewed THAP domain-containing protein 4 Thap4 Mus musculus (Mouse) 569 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q6TUG0 CHOYP_LOC588440.1.1 m.4951 sp DJB11_RAT 67.507 357 111 3 11 362 1 357 1.38E-165 469 DJB11_RAT reviewed DnaJ homolog subfamily B member 11 (ER-associated DNAJ) (ER-associated Hsp40 co-chaperone) (Endoplasmic reticulum DNA J domain-containing protein 3) (ER-resident protein ERdj3) (ERdj3) (ERj3p) (Liver regeneration-related protein LRRGT00084) Dnajb11 Rattus norvegicus (Rat) 358 mRNA modification [GO:0016556]; positive regulation of ATPase activity [GO:0032781]; protein folding [GO:0006457] GO:0005634; GO:0005788; GO:0006457; GO:0016020; GO:0016556; GO:0032781; GO:0034663 0 0 cd06257; PF00226;PF01556; Q75UR0 CHOYP_LOC101167353.1.1 m.40943 sp ANO5_MOUSE 41.772 158 67 5 45 192 58 200 1.38E-25 106 ANO5_MOUSE reviewed Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein homolog) (Transmembrane protein 16E) Ano5 Gdd1 Tmem16e Mus musculus (Mouse) 904 chloride transport [GO:0006821] GO:0005229; GO:0005622; GO:0005789; GO:0005886; GO:0006821; GO:0016021; GO:0031982 0 0 0 PF16178;PF04547; Q7Z4Q2 CHOYP_HEATR3.1.1 m.33423 sp HEAT3_HUMAN 33.045 693 390 21 1 641 1 671 1.38E-86 287 HEAT3_HUMAN reviewed HEAT repeat-containing protein 3 HEATR3 Homo sapiens (Human) 680 0 0 0 0 0 0 Q8AVR4 CHOYP_AGAP_AGAP008287.1.1 m.58727 sp PDC10_XENLA 50.254 197 91 4 14 210 20 209 1.38E-53 173 PDC10_XENLA reviewed Programmed cell death protein 10 pdcd10 Xenopus laevis (African clawed frog) 212 angiogenesis [GO:0001525]; apoptotic process [GO:0006915] GO:0000139; GO:0001525; GO:0005886; GO:0006915 0 0 0 0 Q8BK48 CHOYP_SASB.1.3 m.4029 sp EST2E_MOUSE 32.414 580 322 18 21 583 33 559 1.38E-88 288 EST2E_MOUSE reviewed Pyrethroid hydrolase Ces2e (EC 3.1.1.88) (carboxylesterase 2E) Ces2e Ces5 Mus musculus (Mouse) 559 0 GO:0005615; GO:0005783; GO:0052689; GO:0102209 0 0 0 PF00135; Q8C129 CHOYP_PHUM_PHUM512710.2.2 m.63589 sp LCAP_MOUSE 33.381 701 436 10 28 709 130 818 1.38E-124 399 LCAP_MOUSE reviewed Leucyl-cystinyl aminopeptidase (Cystinyl aminopeptidase) (EC 3.4.11.3) (Oxytocinase) (OTase) Lnpep Mus musculus (Mouse) 1025 cell-cell signaling [GO:0007267]; membrane organization [GO:0061024]; peptide catabolic process [GO:0043171]; protein catabolic process [GO:0030163]; regulation of blood pressure [GO:0008217]; SMAD protein signal transduction [GO:0060395] GO:0004177; GO:0005622; GO:0005765; GO:0005886; GO:0007267; GO:0008217; GO:0008270; GO:0012505; GO:0016020; GO:0016021; GO:0030163; GO:0030659; GO:0042277; GO:0043171; GO:0048471; GO:0060395; GO:0061024; GO:0070006 0 0 0 PF11838;PF01433; Q8C9S4 CHOYP_CJ118.1.1 m.3640 sp CC186_MOUSE 42.619 779 412 7 420 1197 171 915 1.38E-152 484 CC186_MOUSE reviewed Coiled-coil domain-containing protein 186 (Oocyte-testis gene 1 protein) Ccdc186 Otg1 Mus musculus (Mouse) 917 0 0 0 0 0 0 Q8CG65 CHOYP_SSPO.1.14 m.962 sp SSPO_MOUSE 27.332 611 344 28 848 1395 3794 4367 1.38E-37 159 SSPO_MOUSE reviewed SCO-spondin Sspo Mus musculus (Mouse) 4998 cell adhesion [GO:0007155] GO:0005615; GO:0005737; GO:0007155 0 0 0 PF08742;PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q8IWZ3 CHOYP_LOC753709.10.44 m.22246 sp ANKH1_HUMAN 31.087 460 270 14 180 594 230 687 1.38E-41 167 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8NF91 CHOYP_LOC101163060.1.1 m.48240 sp SYNE1_HUMAN 34.513 791 467 11 40 787 18 800 1.38E-134 456 SYNE1_HUMAN reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) 8797 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0006997; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q92485 CHOYP_LOC564392.1.1 m.29701 sp ASM3B_HUMAN 36.804 413 246 6 24 425 21 429 1.38E-92 290 ASM3B_HUMAN reviewed Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B Homo sapiens (Human) 455 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; membrane lipid catabolic process [GO:0046466]; negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685] GO:0004767; GO:0005615; GO:0005886; GO:0006685; GO:0006954; GO:0008081; GO:0016798; GO:0031225; GO:0034122; GO:0045087; GO:0046466; GO:0046872; GO:0050728; GO:0070062 0 0 0 PF00149; Q95WA0 CHOYP_RL26.2.2 m.18727 sp RL26_LITLI 82.143 140 23 1 1 138 1 140 1.38E-79 234 RL26_LITLI reviewed 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) 144 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 0 PF00467;PF16906; Q9BS16 CHOYP_CENPK.1.1 m.8116 sp CENPK_HUMAN 32.143 196 125 4 91 283 78 268 1.38E-26 107 CENPK_HUMAN reviewed Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33) CENPK ICEN37 FKSG14 Homo sapiens (Human) 269 CENP-A containing nucleosome assembly [GO:0034080]; sister chromatid cohesion [GO:0007062] GO:0000777; GO:0005654; GO:0005829; GO:0007062; GO:0034080 0 0 0 PF11802; Q9D9K3 CHOYP_LOC752923.1.1 m.27613 sp AVEN_MOUSE 28.175 252 136 10 61 272 95 341 1.38E-11 67.4 AVEN_MOUSE reviewed Cell death regulator Aven Aven Mus musculus (Mouse) 342 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066] GO:0005622; GO:0006915; GO:0012505; GO:0016020; GO:0043066 0 0 0 0 Q9GZ71 CHOYP_TPM.3.19 m.7777 sp TPM_HALDV 65.455 165 57 0 1 165 1 165 1.38E-64 202 TPM_HALDV reviewed Tropomyosin 0 Haliotis diversicolor (Abalone) (Sulculus diversicolor) 284 0 0 0 0 0 PF00261; Q9I7F7 CHOYP_LOC100168786.1.1 m.19494 sp PR2_DROME 48.837 258 112 5 6 245 7 262 1.38E-71 240 PR2_DROME reviewed Tyrosine-protein kinase PR2 (EC 2.7.10.2) PR2 CG3969 Drosophila melanogaster (Fruit fly) 1337 cell differentiation [GO:0030154]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0006468; GO:0007169; GO:0030154; GO:0031234; GO:0038083; GO:0042127; GO:0045087 0 0 0 PF00786;PF07714;PF07653; Q9NS00 CHOYP_C1GLT.2.2 m.38853 sp C1GLT_HUMAN 53.597 278 124 3 48 322 68 343 1.38E-100 303 C1GLT_HUMAN reviewed "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (B3Gal-T8) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Beta-1,3-galactosyltransferase) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GALT1 Homo sapiens (Human) 363 "angiogenesis [GO:0001525]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; O-glycan processing [GO:0016266]; O-glycan processing, core 1 [GO:0016267]" GO:0000139; GO:0001525; GO:0001822; GO:0016021; GO:0016263; GO:0016266; GO:0016267; GO:0046872; GO:0060576 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02434; Q9PT61 CHOYP_OTX5B.1.1 m.10054 sp OTX5B_XENLA 48.443 289 98 10 81 326 10 290 1.38E-69 221 OTX5B_XENLA reviewed Homeobox protein otx5-B (Orthodenticle homolog 5-B) (XOtx5b) otx5-b otx5b Xenopus laevis (African clawed frog) 290 "anterior/posterior pattern specification [GO:0009952]; eye photoreceptor cell fate commitment [GO:0042706]; positive regulation of rhodopsin gene expression [GO:0045872]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0009952; GO:0042706; GO:0043565; GO:0045872; GO:0045893; GO:0045944 0 0 0 PF00046;PF03529; Q9ULJ7 CHOYP_LOC753709.30.44 m.52241 sp ANR50_HUMAN 31.281 601 350 20 83 626 496 1090 1.38E-55 207 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9UNL2 CHOYP_LOC100120928.1.1 m.40776 sp SSRG_HUMAN 74.306 144 32 2 26 167 1 141 1.38E-72 219 SSRG_HUMAN reviewed Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) SSR3 TRAPG Homo sapiens (Human) 185 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005789; GO:0006614; GO:0016021 0 0 0 PF07074; Q9VTP4 CHOYP_CISY.1.1 m.36667 sp R10AB_DROME 71.739 92 26 0 55 146 45 136 1.38E-32 118 R10AB_DROME reviewed 60S ribosomal protein L10a-2 RpL10Ab CG7283 Drosophila melanogaster (Fruit fly) 217 centrosome duplication [GO:0051298]; maturation of LSU-rRNA [GO:0000470]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; translation [GO:0006412] GO:0000022; GO:0000470; GO:0003723; GO:0003735; GO:0006412; GO:0007052; GO:0022625; GO:0051298 0 0 cd00403; PF00687; Q9W7R3 CHOYP_TEN4.1.1 m.38189 sp TEN4_DANRE 30.444 473 210 14 277 633 394 863 1.38E-54 205 TEN4_DANRE reviewed Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4) tenm4 odz4 tnm4 Danio rerio (Zebrafish) (Brachydanio rerio) 2824 axon guidance [GO:0007411]; central nervous system myelin formation [GO:0032289]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron development [GO:0048666]; positive regulation of gastrulation [GO:2000543]; positive regulation of myelination [GO:0031643]; positive regulation of neuron projection development [GO:0010976]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of myelination [GO:0031641]; self proteolysis [GO:0097264]; signal transduction [GO:0007165] GO:0003824; GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0007156; GO:0007165; GO:0007411; GO:0010976; GO:0016020; GO:0031641; GO:0031643; GO:0032289; GO:0042803; GO:0043005; GO:0046982; GO:0048666; GO:0048714; GO:0097264; GO:2000543 0 0 0 PF05593;PF06484;PF15636; Q9XZ08 CHOYP_LOC100121031.1.2 m.36386 sp EXT3_DROME 35.152 330 179 7 25 322 87 413 1.38E-54 196 EXT3_DROME reviewed Exostosin-3 (EC 2.4.1.223) (Protein brother of tout-velu) botv DEXT3 CG15110 Drosophila melanogaster (Fruit fly) 972 "decapentaplegic signaling pathway [GO:0008101]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparan sulfate proteoglycan metabolic process [GO:0030201]; heparin biosynthetic process [GO:0030210]; multicellular organism development [GO:0007275]; N-acetylglucosamine metabolic process [GO:0006044]; smoothened signaling pathway [GO:0007224]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0001888; GO:0005783; GO:0005789; GO:0005794; GO:0006024; GO:0006044; GO:0007224; GO:0007275; GO:0008101; GO:0008375; GO:0015012; GO:0015014; GO:0016021; GO:0016055; GO:0030201; GO:0030210; GO:0046872 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. 0 0 PF03016;PF09258; Q9Y5Q9 CHOYP_TF3C3.2.3 m.18530 sp TF3C3_HUMAN 37.993 608 348 5 1 587 287 886 1.38E-134 417 TF3C3_HUMAN reviewed General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) 886 "5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase III promoter [GO:0006383]; tRNA transcription from RNA polymerase III promoter [GO:0042797]" GO:0000127; GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006383; GO:0031965; GO:0042791; GO:0042797 0 0 0 PF13181; Q9Z1J2 CHOYP_LOC100349662.1.1 m.60910 sp NEK4_MOUSE 43.682 277 147 4 13 288 11 279 1.38E-68 240 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; A2A870 CHOYP_BRAFLDRAFT_64593.1.1 m.54376 sp FBF1_MOUSE 30.035 566 358 6 817 1376 634 1167 1.39E-67 253 FBF1_MOUSE reviewed Fas-binding factor 1 (FBF-1) Fbf1 Mus musculus (Mouse) 1173 apical junction assembly [GO:0043297]; cilium assembly [GO:0042384]; establishment of epithelial cell polarity [GO:0090162] GO:0000922; GO:0005813; GO:0005814; GO:0030054; GO:0042384; GO:0043297; GO:0090162; GO:0097539 0 0 0 0 A4IF63 CHOYP_BRAFLDRAFT_84666.3.3 m.32767 sp TRIM2_BOVIN 25.339 221 139 5 325 533 536 742 1.39E-08 61.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4K526 CHOYP_ISCW_ISCW006146.1.2 m.2102 sp TM256_BUFGR 47.917 96 49 1 51 146 5 99 1.39E-25 96.7 TM256_BUFGR reviewed Transmembrane protein 256 homolog 0 Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) 114 0 GO:0005886; GO:0016021 0 0 0 PF04241; A7RX26 CHOYP_LOC100371597.1.1 m.3330 sp HUTI_NEMVE 60.303 330 126 3 5 333 3 328 1.39E-143 415 HUTI_NEMVE reviewed Probable imidazolonepropionase (EC 3.5.2.7) (Amidohydrolase domain-containing protein 1 homolog) amdhd1 v1g163675 Nematostella vectensis (Starlet sea anemone) 429 histidine catabolic process to glutamate and formamide [GO:0019556]; histidine catabolic process to glutamate and formate [GO:0019557] GO:0005737; GO:0019556; GO:0019557; GO:0046872; GO:0050480 PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. 0 cd01296; PF01979; C0HJF3 CHOYP_BRAFLDRAFT_163244.1.3 m.5670 sp VKT3_HETCR 61.905 42 16 0 92 133 2 43 1.39E-13 65.9 VKT3_HETCR reviewed Tau-stichotoxin-Hcr2d (Tau-SHTX-Hcr2d) (Analgesic polypeptide HC3) (APHC3) 0 Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus) 56 0 GO:0004867; GO:0005576; GO:0042151 0 0 0 PF00014; D2GXS7 CHOYP_BRAFLDRAFT_87327.13.13 m.63999 sp TRIM2_AILME 23.129 147 106 3 150 294 602 743 1.39E-07 57.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2YVH7 CHOYP_BRAFLDRAFT_125405.1.1 m.5741 sp LECM_OXYSU 25.984 127 85 3 169 295 37 154 1.39E-06 50.8 LECM_OXYSU reviewed C-type lectin mannose-binding isoform (CTL) (Venom C-type lectin mannose-binding isoform 1) 0 Oxyuranus scutellatus (Coastal taipan) 158 0 GO:0005576; GO:0030246; GO:0046872 0 0 0 PF00059; E2RSQ2 CHOYP_LOC100378946.1.1 m.48641 sp HORM1_CANLF 47.303 241 124 2 1 240 1 239 1.39E-71 238 HORM1_CANLF reviewed HORMA domain-containing protein 1 HORMAD1 Canis lupus familiaris (Dog) (Canis familiaris) 395 blastocyst development [GO:0001824]; meiotic DNA double-strand break formation [GO:0042138]; meiotic nuclear division [GO:0007126]; meiotic recombination checkpoint [GO:0051598]; meiotic sister chromatid cohesion [GO:0051177]; oogenesis [GO:0048477]; regulation of homologous chromosome segregation [GO:0060629]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130] GO:0001824; GO:0005634; GO:0005694; GO:0007126; GO:0007130; GO:0007283; GO:0042138; GO:0048477; GO:0051177; GO:0051598; GO:0060629 0 0 0 PF02301; H2A0M0 CHOYP_NRP.2.4 m.39720 sp NRP_PINMG 29.268 246 155 7 327 565 450 683 1.39E-28 124 NRP_PINMG reviewed Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 686 0 GO:0005576 0 0 0 0 O95049 CHOYP_BRAFLDRAFT_93411.1.3 m.13317 sp ZO3_HUMAN 35.498 662 350 15 312 958 187 786 1.39E-98 343 ZO3_HUMAN reviewed Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP3 ZO3 Homo sapiens (Human) 919 0 GO:0005634; GO:0005886; GO:0005923 0 0 0 PF00625;PF00595;PF07653; P03162 CHOYP_LOC100494049.4.8 m.54443 sp DPOL_DHBV1 25.61 164 117 4 243 405 496 655 1.39E-08 61.6 DPOL_DHBV1 reviewed Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (strain United States/DHBV-16) (DHBV) 836 "DNA replication [GO:0006260]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]" GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006260; GO:0046872; GO:0090502 0 0 0 PF00336;PF00242;PF00078; P09487 CHOYP_BRAFLDRAFT_119115.1.1 m.27057 sp PPBT_BOVIN 48.795 332 156 6 6 331 174 497 1.39E-102 314 PPBT_BOVIN reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) 524 biomineral tissue development [GO:0031214]; cellular response to organic cyclic compound [GO:0071407]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; osteoblast differentiation [GO:0001649]; response to antibiotic [GO:0046677]; response to vitamin D [GO:0033280] GO:0001649; GO:0001958; GO:0003006; GO:0004035; GO:0005578; GO:0005886; GO:0016462; GO:0031214; GO:0031225; GO:0033280; GO:0046677; GO:0046872; GO:0065010; GO:0070062; GO:0071407 0 0 0 PF00245; P0C2C1 CHOYP_SMP_102490.2.2 m.25308 sp RM30_RAT 34.532 139 74 5 35 172 31 153 1.39E-14 72.4 RM30_RAT reviewed "39S ribosomal protein L30, mitochondrial (L30mt) (MRP-L30)" Mrpl30 Rattus norvegicus (Rat) 160 0 GO:0005739; GO:0005840 0 0 cd01658; PF00327; P16157 CHOYP_LOC579631.2.4 m.33791 sp ANK1_HUMAN 31.712 514 292 7 182 659 73 563 1.39E-67 244 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P27473 CHOYP_BRAFLDRAFT_91636.2.11 m.39118 sp IFI44_PANTR 26.174 298 177 13 22 311 23 285 1.39E-21 97.8 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P47224 CHOYP_LOC100708329.1.1 m.3319 sp MSS4_HUMAN 50.435 115 54 1 18 129 8 122 1.39E-40 134 MSS4_HUMAN reviewed Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) RABIF MSS4 RASGRF3 Homo sapiens (Human) 123 membrane fusion [GO:0061025]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005622; GO:0007264; GO:0008270; GO:0015031; GO:0061025 0 0 0 PF04421; P53471 CHOYP_ACT2.3.3 m.41139 sp ACT2_SCHMA 95.679 162 7 0 1 162 191 352 1.39E-112 327 ACT2_SCHMA reviewed Actin-2 0 Schistosoma mansoni (Blood fluke) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P56597 CHOYP_LOC100371808.2.2 m.62772 sp NDK5_HUMAN 65.934 182 62 0 24 205 4 185 1.39E-93 276 NDK5_HUMAN reviewed Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (Inhibitor of p53-induced apoptosis-beta) (IPIA-beta) (Testis-specific nm23 homolog) (nm23-H5) NME5 Homo sapiens (Human) 212 cilium assembly [GO:0042384]; CTP biosynthetic process [GO:0006241]; epithelial cilium movement [GO:0003351]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; nucleoside metabolic process [GO:0009116]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228]; ventricular system development [GO:0021591] GO:0003351; GO:0004550; GO:0005622; GO:0006183; GO:0006228; GO:0006241; GO:0007283; GO:0007286; GO:0009116; GO:0021591; GO:0036126; GO:0042384; GO:1902176 0 0 0 PF05186;PF00334; P61255 CHOYP_RL26.1.2 m.15517 sp RL26_MOUSE 86.325 117 16 0 23 139 1 117 1.39E-71 214 RL26_MOUSE reviewed 60S ribosomal protein L26 (Silica-induced gene 20 protein) (SIG-20) Rpl26 Mus musculus (Mouse) 145 cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0002181; GO:0003735; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0044822; GO:0070062 0 0 0 PF00467;PF16906; P82890 CHOYP_PPAC1.1.1 m.51347 sp PPAC1_DROME 51.351 148 70 2 12 159 3 148 1.39E-47 154 PPAC1_DROME reviewed Low molecular weight phosphotyrosine protein phosphatase 1 (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase 1) (EC 3.1.3.2) (PTPase 1) primo-1 CG31311 Drosophila melanogaster (Fruit fly) 155 protein dephosphorylation [GO:0006470] GO:0003993; GO:0004725; GO:0005634; GO:0005737; GO:0006470 0 0 cd00115; PF01451; Q06807 CHOYP_MEGF6.17.59 m.24985 sp TIE2_BOVIN 30.573 157 68 5 10 151 198 328 1.39E-13 77 TIE2_BOVIN reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TIE-2) (CD antigen CD202b) TEK TIE-2 TIE2 Bos taurus (Bovine) 1125 angiogenesis [GO:0001525]; endothelial cell proliferation [GO:0001935]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell apoptotic process [GO:2000352]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of establishment or maintenance of cell polarity [GO:0032878]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0001725; GO:0001934; GO:0001935; GO:0002040; GO:0004713; GO:0004714; GO:0005524; GO:0005576; GO:0005737; GO:0005884; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007169; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016324; GO:0016525; GO:0018108; GO:0032878; GO:0034446; GO:0043552; GO:0045121; GO:0045766; GO:0046777; GO:0048014; GO:0051259; GO:0051894; GO:0051897; GO:0060347; GO:0070374; GO:1902533; GO:2000251; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q09654 CHOYP_LOC100373444.46.79 m.39415 sp TRI23_CAEEL 29.126 103 65 3 24 120 119 219 1.39E-06 54.7 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q09655 CHOYP_BRAFLDRAFT_64382.2.2 m.31686 sp GPAN1_CAEEL 35.294 85 55 0 33 117 119 203 1.39E-10 61.6 GPAN1_CAEEL reviewed G patch domain and ankyrin repeat-containing protein 1 homolog ZK1320.7 Caenorhabditis elegans 371 0 GO:0003676 0 0 0 PF12796;PF01585; Q12796 CHOYP_PNRC2.1.1 m.25310 sp PNRC1_HUMAN 61.224 49 19 0 72 120 279 327 1.39E-11 63.2 PNRC1_HUMAN reviewed Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) PNRC1 PROL2 Homo sapiens (Human) 327 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 0 Q14BN4 CHOYP_SLMAP.2.8 m.897 sp SLMAP_HUMAN 40.123 815 387 18 15 750 3 795 1.39E-147 462 SLMAP_HUMAN reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) 828 muscle contraction [GO:0006936] GO:0005790; GO:0005815; GO:0005887; GO:0006936; GO:0042383 0 0 0 PF00498; Q24K15 CHOYP_FGL2.5.9 m.52162 sp ANGP4_BOVIN 38.426 216 112 5 101 316 279 473 1.39E-38 145 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q28BX9 CHOYP_LOC100865656.1.1 m.47567 sp C2CD5_XENTR 41.096 730 334 16 392 1086 320 988 1.39E-167 524 C2CD5_XENTR reviewed C2 domain-containing protein 5 (138 kDa C2 domain-containing phosphoprotein) c2cd5 TGas115n11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1014 cellular response to insulin stimulus [GO:0032869]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; intracellular protein transmembrane transport [GO:0065002]; positive regulation of glucose transport [GO:0010828]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of vesicle fusion [GO:0031340] GO:0005509; GO:0005544; GO:0005886; GO:0005938; GO:0010828; GO:0030659; GO:0031340; GO:0032587; GO:0032869; GO:0038028; GO:0065002; GO:0090314 0 0 0 PF00168; Q29486 CHOYP_PPBT.2.4 m.21773 sp PPBT_FELCA 48.269 491 241 7 1 485 8 491 1.39E-149 440 PPBT_FELCA reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Felis catus (Cat) (Felis silvestris catus) 524 dephosphorylation [GO:0016311] GO:0004035; GO:0016311; GO:0046658; GO:0046872 0 0 0 PF00245; Q502K3 CHOYP_AFUA_1G01020.16.50 m.23836 sp ANR52_DANRE 35.484 341 219 1 7 346 24 364 1.39E-58 207 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q55E58 CHOYP_BRAFLDRAFT_129004.3.15 m.32103 sp PATS1_DICDI 25.083 303 171 12 377 667 1765 2023 1.39E-16 89.4 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5BIM1 CHOYP_LOC100374741.14.83 m.17528 sp TRI45_BOVIN 29.213 178 103 8 11 169 133 306 1.39E-07 56.6 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5ND28 CHOYP_MEG10.14.91 m.21948 sp SREC_MOUSE 31.25 288 144 13 199 483 153 389 1.39E-19 96.7 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5TZ51 CHOYP_LOC100899945.2.3 m.48846 sp MPV17_DANRE 39.205 176 104 2 1 173 1 176 1.39E-40 139 MPV17_DANRE reviewed Protein Mpv17 mpv17 zgc:63573 Danio rerio (Zebrafish) (Brachydanio rerio) 177 0 GO:0005743; GO:0016021 0 0 0 PF04117; Q5UQ35 CHOYP_LOC100372473.4.5 m.48798 sp YR811_MIMIV 24.231 260 168 9 5 250 7 251 1.39E-11 67.8 YR811_MIMIV reviewed Putative ariadne-like RING finger protein R811 MIMI_R811 Acanthamoeba polyphaga mimivirus (APMV) 990 0 GO:0008270 0 0 0 PF01485; Q5ZMT7 CHOYP_LOC100369003.1.2 m.12063 sp ADCK1_CHICK 55.491 173 77 0 42 214 19 191 1.39E-57 192 ADCK1_CHICK reviewed Uncharacterized aarF domain-containing protein kinase 1 (EC 2.7.11.-) ADCK1 RCJMB04_1d9 Gallus gallus (Chicken) 519 0 GO:0004674; GO:0005524; GO:0005576 0 0 0 PF03109; Q62165 CHOYP_LOC100368987.1.1 m.6182 sp DAG1_MOUSE 29.368 933 519 25 1 843 11 893 1.39E-85 295 DAG1_MOUSE reviewed Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] Dag1 Dag-1 Mus musculus (Mouse) 893 basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium-dependent cell-matrix adhesion [GO:0016340]; commissural neuron axon guidance [GO:0071679]; cytoskeletal anchoring at plasma membrane [GO:0007016]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; modulation by virus of host morphology or physiology [GO:0019048]; morphogenesis of an epithelial sheet [GO:0002011]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of protein kinase B signaling [GO:0051898]; nerve maturation [GO:0021682]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; response to peptide hormone [GO:0043434]; Schwann cell development [GO:0014044] GO:0002011; GO:0003779; GO:0005509; GO:0005604; GO:0005615; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0005913; GO:0005925; GO:0006509; GO:0006607; GO:0007016; GO:0008307; GO:0009279; GO:0010470; GO:0010717; GO:0014044; GO:0015631; GO:0016010; GO:0016011; GO:0016020; GO:0016021; GO:0016323; GO:0016340; GO:0017166; GO:0019048; GO:0021682; GO:0022011; GO:0030027; GO:0030175; GO:0030336; GO:0033268; GO:0034453; GO:0042169; GO:0042383; GO:0043034; GO:0043409; GO:0043434; GO:0045121; GO:0045211; GO:0051393; GO:0051898; GO:0060441; GO:0060445; GO:0070062; GO:0070938; GO:0071679; GO:0071711; GO:1904261 0 0 0 PF05454; Q6DIB5 CHOYP_LOC101075314.3.3 m.61847 sp MEG10_MOUSE 37.551 245 127 11 186 418 433 663 1.39E-27 120 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6NW29 CHOYP_DPSE_GA10259.1.1 m.36297 sp RWDD4_HUMAN 45.503 189 93 2 1 182 1 186 1.39E-55 176 RWDD4_HUMAN reviewed RWD domain-containing protein 4 (Protein FAM28A) RWDD4 FAM28A RWDD4A Homo sapiens (Human) 188 0 0 0 0 0 PF05773; Q6PFY8 CHOYP_TRIM45.3.9 m.14159 sp TRI45_MOUSE 29.614 233 142 7 5 224 127 350 1.39E-13 75.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6RFH5 CHOYP_WDR74.1.1 m.19017 sp WDR74_HUMAN 38.66 388 223 6 10 386 1 384 1.39E-93 289 WDR74_HUMAN reviewed WD repeat-containing protein 74 (NOP seven-associated protein 1) WDR74 NSA1 Homo sapiens (Human) 385 blastocyst formation [GO:0001825]; ribosomal large subunit biogenesis [GO:0042273]; RNA metabolic process [GO:0016070] GO:0001825; GO:0005634; GO:0005730; GO:0016070; GO:0030687; GO:0042273 0 0 0 PF00400; Q6VV64 CHOYP_LOC100907151.1.1 m.33509 sp KCNKI_MOUSE 27.296 392 242 11 4 387 19 375 1.39E-30 124 KCNKI_MOUSE reviewed Potassium channel subfamily K member 18 (Two-pore-domain potassium channel TRESK) Kcnk18 Tresk-2 Tresk2 Mus musculus (Mouse) 394 cellular response to pH [GO:0071467]; potassium ion export [GO:0071435]; potassium ion transport [GO:0006813]; stabilization of membrane potential [GO:0030322] GO:0005886; GO:0005887; GO:0006813; GO:0015269; GO:0015271; GO:0022841; GO:0030322; GO:0071435; GO:0071467 0 0 0 PF07885; Q7K556 CHOYP_LOC100116049.1.1 m.54372 sp TTD14_DROME 58.933 375 150 2 66 436 65 439 1.39E-168 484 TTD14_DROME reviewed TRPL translocation defect protein 14 Ttd14 CG30118 Drosophila melanogaster (Fruit fly) 475 cellular response to light stimulus [GO:0071482]; photoreceptor cell maintenance [GO:0045494]; positive regulation of intracellular protein transport [GO:0090316]; protein transport [GO:0015031] GO:0005525; GO:0005829; GO:0015031; GO:0035091; GO:0045494; GO:0070300; GO:0071482; GO:0090316 0 0 0 0 Q7SYJ9 CHOYP_SPAG7.1.1 m.66661 sp SPAG7_DANRE 51.477 237 104 4 2 236 3 230 1.39E-69 218 SPAG7_DANRE reviewed Sperm-associated antigen 7 homolog spag7 Danio rerio (Zebrafish) (Brachydanio rerio) 230 0 GO:0003676 0 0 0 PF01424; Q7Z5L3 CHOYP_TVAG_342430.1.1 m.62725 sp C1QL2_HUMAN 33.094 139 88 3 284 419 148 284 1.39E-11 68.2 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q80W96 CHOYP_ISCA1.1.2 m.17578 sp ISCA1_RAT 67.717 127 41 0 10 136 3 129 1.39E-62 190 ISCA1_RAT reviewed "Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA)" Isca1 Hbld2 Rattus norvegicus (Rat) 129 endocrine process [GO:0050886]; iron-sulfur cluster assembly [GO:0016226]; protein maturation by iron-sulfur cluster transfer [GO:0097428]; sulfur compound metabolic process [GO:0006790] GO:0005198; GO:0005759; GO:0006790; GO:0008198; GO:0016226; GO:0050886; GO:0051537; GO:0051539; GO:0097428 0 0 0 PF01521; Q8CG65 CHOYP_SSPO.6.14 m.26542 sp SSPO_MOUSE 27.422 609 342 28 959 1504 3794 4365 1.39E-37 159 SSPO_MOUSE reviewed SCO-spondin Sspo Mus musculus (Mouse) 4998 cell adhesion [GO:0007155] GO:0005615; GO:0005737; GO:0007155 0 0 0 PF08742;PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q8ITC3 CHOYP_RS19.6.12 m.29999 sp RS19_ARGIR 73.109 119 31 1 1 119 27 144 1.39E-62 190 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8NBN7 CHOYP_LOC100876659.1.1 m.19403 sp RDH13_HUMAN 39.163 263 159 1 23 284 11 273 1.39E-52 179 RDH13_HUMAN reviewed Retinol dehydrogenase 13 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 7C member 3) RDH13 SDR7C3 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) 331 eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842] GO:0005743; GO:0009644; GO:0010842; GO:0016491; GO:0042462; GO:0052650 0 0 0 PF00106; Q8NEF3 CHOYP_CC112.1.2 m.41143 sp CC112_HUMAN 35.593 118 44 1 2 87 318 435 1.39E-15 73.6 CC112_HUMAN reviewed Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1) CCDC112 MBC1 Homo sapiens (Human) 446 0 0 0 0 0 0 Q8R1Q3 CHOYP_FGL1.4.6 m.47116 sp ANGL7_MOUSE 34.877 324 172 8 51 359 33 332 1.39E-55 187 ANGL7_MOUSE reviewed Angiopoietin-related protein 7 (Angiopoietin-like protein 7) Angptl7 Mus musculus (Mouse) 337 0 GO:0005576 0 0 0 PF00147; Q8VBW5 CHOYP_LOC100313559.1.1 m.47009 sp BBX_MOUSE 46.622 148 66 3 11 145 80 227 1.39E-31 136 BBX_MOUSE reviewed HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2) Bbx Hbp2 Mus musculus (Mouse) 907 "bone development [GO:0060348]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0060348 0 0 0 PF09667;PF00505; Q8WVZ9 CHOYP_BACH1.9.17 m.18419 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 1.39E-08 61.6 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q90YV7 CHOYP_RL8.3.10 m.22753 sp RL11_ICTPU 87.963 108 13 0 215 322 6 113 1.39E-61 197 RL11_ICTPU reviewed 60S ribosomal protein L11 rpl11 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 178 protein localization to nucleus [GO:0034504]; translation [GO:0006412] GO:0003735; GO:0005730; GO:0005840; GO:0006412; GO:0019843; GO:0034504 0 0 0 PF00281;PF00673; Q92038 CHOYP_LOC100564278.1.1 m.1666 sp ACOD_CYPCA 66.802 247 81 1 36 281 77 323 1.39E-117 343 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; Q920Q2 CHOYP_BRAFLDRAFT_213587.1.1 m.51383 sp REV1_MOUSE 50.595 504 233 5 256 755 334 825 1.39E-158 511 REV1_MOUSE reviewed DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) Rev1 Rev1l Mus musculus (Mouse) 1249 error-prone translesion synthesis [GO:0042276]; response to UV [GO:0009411] GO:0003684; GO:0005634; GO:0009411; GO:0017125; GO:0042276; GO:0046872 0 0 0 PF16589;PF14377;PF00817;PF11799;PF16727; Q93YS4 CHOYP_LOC664105.1.1 m.52422 sp AB22G_ARATH 38.53 558 324 9 3 552 163 709 1.39E-124 388 AB22G_ARATH reviewed ABC transporter G family member 22 (ABC transporter ABCG.22) (AtABCG22) (White-brown complex homolog protein 23) (AtWBC23) ABCG22 WBC23 At5g06530 F15M7.6 Arabidopsis thaliana (Mouse-ear cress) 751 response to water deprivation [GO:0009414]; transpiration [GO:0010148] GO:0005524; GO:0005886; GO:0009414; GO:0010148; GO:0016021; GO:0042626 0 0 0 PF01061;PF00005; Q963B7 CHOYP_ACSA.1.1 m.61299 sp RL9_SPOFR 59.434 106 43 0 1 106 1 106 1.39E-38 130 RL9_SPOFR reviewed 60S ribosomal protein L9 RpL9 Spodoptera frugiperda (Fall armyworm) 190 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00347; Q96GP6 CHOYP_LOC101062986.3.3 m.63790 sp SREC2_HUMAN 39.333 150 82 7 99 247 219 360 1.39E-16 84.3 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q96GP6 CHOYP_MEG10.20.91 m.24554 sp SREC2_HUMAN 38.961 77 46 1 201 277 273 348 1.39E-09 62.4 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q96MM6 CHOYP_HS12A.2.33 m.20114 sp HS12B_HUMAN 29.459 370 154 11 10 333 61 369 1.39E-29 122 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96QF0 CHOYP_BRAFLDRAFT_199346.3.3 m.65798 sp RAB3I_HUMAN 47.239 326 146 4 267 580 160 471 1.39E-90 290 RAB3I_HUMAN reviewed Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein) RAB3IP RABIN8 Homo sapiens (Human) 476 cilium assembly [GO:0042384]; Golgi to plasma membrane transport [GO:0006893]; protein localization to organelle [GO:0033365]; protein targeting to membrane [GO:0006612] GO:0005634; GO:0005813; GO:0005829; GO:0005856; GO:0006612; GO:0006893; GO:0017112; GO:0030027; GO:0033365; GO:0036064; GO:0042384 0 0 0 PF06428; Q96WV6 CHOYP_contig_027445 m.31166 sp YHU2_SCHPO 34.071 226 145 1 1 226 1655 1876 1.39E-06 53.5 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q99315 CHOYP_LOC100707389.1.1 m.38660 sp YG31B_YEAST 27.235 727 444 14 97 744 602 1322 1.39E-78 283 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q99JY4 CHOYP_ISCW_ISCW013325.2.2 m.49250 sp TRABD_MOUSE 28.571 231 147 5 1 219 95 319 1.39E-13 73.2 TRABD_MOUSE reviewed TraB domain-containing protein Trabd Mus musculus (Mouse) 376 0 0 0 0 0 PF01963; Q9BH04 CHOYP_KBRS1.2.2 m.43295 sp KBRS1_MACFA 58.333 108 45 0 9 116 70 177 1.39E-42 142 KBRS1_MACFA reviewed NF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1) NKIRAS1 QflA-10220 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 192 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0007264; GO:0016020 0 0 0 PF00071; Q9DG68 CHOYP_HSP7D.2.3 m.34787 sp RLA0_RANSY 75 176 44 0 1 176 1 176 1.39E-90 271 RLA0_RANSY reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) 315 ribosome biogenesis [GO:0042254] GO:0005840; GO:0042254 0 0 0 PF00466; Q9ESN6 CHOYP_LOC100213744.9.19 m.37687 sp TRIM2_MOUSE 22.264 265 189 8 299 552 486 744 1.39E-07 58.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9FVX1 CHOYP_PMAR_PMAR003946.1.2 m.25412 sp GRXC3_ARATH 45.192 104 48 3 2 104 32 127 1.39E-20 82.8 GRXC3_ARATH reviewed Glutaredoxin-C3 (AtGrxC3) GRXC3 At1g77370 F2P24.8 Arabidopsis thaliana (Mouse-ear cress) 130 cell redox homeostasis [GO:0045454] GO:0005794; GO:0009055; GO:0015035; GO:0045454 0 0 0 PF00462; Q9HCJ0 CHOYP_TNRC6A.1.2 m.16253 sp TNR6C_HUMAN 28.373 793 398 32 749 1452 884 1595 1.39E-43 178 TNR6C_HUMAN reviewed Trinucleotide repeat-containing gene 6C protein TNRC6C KIAA1582 Homo sapiens (Human) 1690 "gene silencing by miRNA [GO:0035195]; miRNA mediated inhibition of translation [GO:0035278]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; posttranscriptional gene silencing by RNA [GO:0035194]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]" GO:0000166; GO:0003723; GO:0005829; GO:0007223; GO:0035194; GO:0035195; GO:0035278; GO:0048015; GO:0060213; GO:1900153 0 0 0 PF10427;PF12938;PF00076;PF16608;PF00627; Q9I925 CHOYP_BRAFLDRAFT_253667.2.2 m.61006 sp FUCL7_ANGJA 31.544 149 87 7 13 149 38 183 1.39E-07 52 FUCL7_ANGJA reviewed Fucolectin-7 0 Anguilla japonica (Japanese eel) 189 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9TV36 CHOYP_FBN1.1.1 m.8667 sp FBN1_PIG 37.101 407 161 6 1 312 205 611 1.39E-75 255 FBN1_PIG reviewed Fibrillin-1 [Cleaved into: Asprosin] FBN1 Sus scrofa (Pig) 2871 activation of protein kinase A activity [GO:0034199]; anatomical structure morphogenesis [GO:0009653]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein kinase A signaling [GO:0010737]; regulation of cellular response to growth factor stimulus [GO:0090287] GO:0005179; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005622; GO:0006006; GO:0008201; GO:0009653; GO:0010737; GO:0034199; GO:0042593; GO:0090287 0 0 0 PF12662;PF07645;PF00683; Q9V4M2 CHOYP_BRAFLDRAFT_87307.2.5 m.32960 sp WECH_DROME 36.047 86 51 2 155 237 540 624 1.39E-08 58.9 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; Q9VCA8 CHOYP_LOC100641396.25.27 m.64064 sp ANKHM_DROME 31.236 445 259 13 7 433 619 1034 1.39E-43 167 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VFK6 CHOYP_LOC101237965.1.4 m.10038 sp KMT5A_DROME 35.185 108 60 5 29 133 555 655 1.39E-10 60.8 KMT5A_DROME reviewed Histone-lysine N-methyltransferase pr-set7 (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (dSET8) pr-set7 KMT5A CG3307 Drosophila melanogaster (Fruit fly) 691 "cell division [GO:0051301]; chromosome condensation [GO:0030261]; DNA damage checkpoint [GO:0000077]; histone H4-K20 monomethylation [GO:0034771]; histone methylation [GO:0016571]; mitotic nuclear division [GO:0007067]; negative regulation of histone acetylation [GO:0035067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000077; GO:0005634; GO:0005700; GO:0006351; GO:0006355; GO:0007067; GO:0016571; GO:0030261; GO:0034771; GO:0035067; GO:0042799; GO:0051301 0 0 0 PF00856; A2AJ76 CHOYP_CNTN6.1.2 m.781 sp HMCN2_MOUSE 20.766 809 519 28 148 868 2477 3251 1.40E-23 112 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A3RLT6 CHOYP_RSSA.7.10 m.47560 sp RSSA_PINFU 65 80 25 3 1 79 198 275 1.40E-20 88.2 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A9ULX8 CHOYP_TM237.1.1 m.11169 sp TM237_XENLA 26.935 323 204 9 141 455 89 387 1.40E-23 105 TM237_XENLA reviewed Transmembrane protein 237 tmem237 Xenopus laevis (African clawed frog) 389 cilium assembly [GO:0042384]; regulation of Wnt signaling pathway [GO:0030111] GO:0016021; GO:0030111; GO:0035869; GO:0042384 0 0 0 PF15383; B2RZ55 CHOYP_SIR7.1.1 m.7338 sp SIR7_RAT 57.79 353 149 0 35 387 9 361 1.40E-142 427 SIR7_RAT reviewed NAD-dependent protein deacetylase sirtuin-7 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7) Sirt7 Rattus norvegicus (Rat) 402 histone H3 deacetylation [GO:0070932]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription involved in exit from mitosis [GO:0007072]; rRNA transcription [GO:0009303] GO:0000122; GO:0003682; GO:0005731; GO:0005737; GO:0007072; GO:0009303; GO:0046872; GO:0070403; GO:0070932; GO:0097372 0 0 0 PF02146; B9EJ86 CHOYP_OSBL8.2.2 m.33633 sp OSBL8_MOUSE 58.284 338 117 8 55 370 101 436 1.40E-121 375 OSBL8_MOUSE reviewed Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) Osbpl8 Kiaa1451 Orp8 Mus musculus (Mouse) 889 activation of protein kinase B activity [GO:0032148]; fat cell differentiation [GO:0045444]; negative regulation of cell migration [GO:0030336]; negative regulation of sequestering of triglyceride [GO:0010891]; phospholipid transport [GO:0015914]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein kinase B signaling [GO:0051897]; protein localization to nuclear pore [GO:0090204] GO:0001786; GO:0005548; GO:0005789; GO:0010891; GO:0015485; GO:0015914; GO:0016020; GO:0016021; GO:0030336; GO:0031965; GO:0032148; GO:0032541; GO:0045444; GO:0046628; GO:0051897; GO:0070273; GO:0090204; GO:2001275 0 0 0 PF01237;PF00169; H2LRU7 CHOYP_PKD2L1.1.1 m.12843 sp PKD2_ORYLA 25.714 175 127 1 1 175 525 696 1.40E-14 74.3 PKD2_ORYLA reviewed Polycystin-2 (Polycystic kidney disease 2 protein homolog) pkd2 Oryzias latipes (Japanese rice fish) (Japanese killifish) 901 detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; ion transport [GO:0006811] GO:0003127; GO:0005509; GO:0005783; GO:0005929; GO:0006811; GO:0016021; GO:0050982; GO:0060170 0 0 0 PF08016; O08585 CHOYP_LOC763681.1.1 m.19437 sp CLCA_MOUSE 45.662 219 82 5 32 224 28 235 1.40E-56 182 CLCA_MOUSE reviewed Clathrin light chain A (Lca) Clta Mus musculus (Mouse) 235 clathrin-mediated endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] GO:0005198; GO:0006886; GO:0016020; GO:0016023; GO:0030125; GO:0030130; GO:0030132; GO:0032050; GO:0043231; GO:0071439; GO:0072583 0 0 0 PF01086; O70277 CHOYP_BRAFLDRAFT_87340.2.6 m.32697 sp TRIM3_RAT 25.373 134 90 3 57 184 614 743 1.40E-07 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_LOC100373444.30.79 m.32655 sp TRIM3_HUMAN 22.093 344 199 15 229 524 422 744 1.40E-10 67.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02594 CHOYP_CALM.27.50 m.36253 sp CALM_ELEEL 70.068 147 43 1 1 147 1 146 1.40E-68 207 CALM_ELEEL reviewed Calmodulin (CaM) calm Electrophorus electricus (Electric eel) (Gymnotus electricus) 149 0 GO:0005509 0 0 0 PF13499; P04323 CHOYP_contig_001297 m.1329 sp POL3_DROME 38.764 178 99 4 264 432 148 324 1.40E-27 119 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P09760 CHOYP_FERT2.1.1 m.61059 sp FER_RAT 36.709 395 230 11 233 613 423 811 1.40E-68 241 FER_RAT reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) (Proto-oncogene c-Fer) (Tyrosine-protein kinase FLK) (p94-Fer) Fer Fert2 Flk Rattus norvegicus (Rat) 823 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cellular response to insulin stimulus [GO:0032869]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; epidermal growth factor receptor signaling pathway [GO:0007173]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of cell proliferation [GO:0042127]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0000226; GO:0001932; GO:0003779; GO:0004715; GO:0005102; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005856; GO:0005938; GO:0006935; GO:0007155; GO:0007173; GO:0008092; GO:0008283; GO:0008289; GO:0010591; GO:0017137; GO:0018108; GO:0019221; GO:0019901; GO:0030054; GO:0030154; GO:0030335; GO:0030838; GO:0031234; GO:0031532; GO:0032496; GO:0032869; GO:0033007; GO:0034446; GO:0034614; GO:0035426; GO:0036119; GO:0038028; GO:0038083; GO:0038095; GO:0038109; GO:0042058; GO:0042127; GO:0042995; GO:0043304; GO:0044331; GO:0045087; GO:0045295; GO:0045296; GO:0048008; GO:0050839; GO:0050904; GO:0051092 0 0 0 PF00611;PF07714;PF00017; P10394 CHOYP_LOC100708199.3.6 m.23798 sp POL4_DROME 29.354 1022 600 21 311 1256 254 1229 1.40E-122 417 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P16157 CHOYP_AASI_1435.12.35 m.33100 sp ANK1_HUMAN 37.063 572 339 2 340 890 82 653 1.40E-94 330 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18737 CHOYP_GZF1.1.2 m.7747 sp ZG8_XENLA 36.5 200 112 9 885 1080 8 196 1.40E-29 120 ZG8_XENLA reviewed Gastrula zinc finger protein XlCGF8.2DB (Fragment) 0 Xenopus laevis (African clawed frog) 196 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; P20825 CHOYP_LOC100142313.2.2 m.8571 sp POL2_DROME 35.574 357 221 5 180 530 100 453 1.40E-66 236 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P23965 CHOYP_LOC100706747.1.1 m.14818 sp ECI1_RAT 54.8 250 111 1 43 290 39 288 1.40E-99 296 ECI1_RAT reviewed "Enoyl-CoA delta isomerase 1, mitochondrial (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase)" Eci1 Dci Rattus norvegicus (Rat) 289 fatty acid beta-oxidation [GO:0006635] GO:0004165; GO:0005739; GO:0005759; GO:0006635; GO:0042802 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00378; P24081 CHOYP_LOC100889156.2.10 m.9690 sp AN_NPVOP 25 240 135 9 16 234 36 251 1.40E-06 52.4 AN_NPVOP reviewed Alkaline nuclease (AN) (EC 3.1.-.-) ALK-EXO ORF131 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) 424 0 GO:0003677; GO:0004519; GO:0004527; GO:0042025 0 0 0 PF01771; P26591 CHOYP_GLRK.1.3 m.29909 sp GLRK_LYMST 53.875 271 117 6 1 264 648 917 1.40E-89 287 GLRK_LYMST reviewed Glutamate receptor 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 917 0 GO:0004970; GO:0005234; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF01094;PF00060;PF10613; P26652 CHOYP_TIMP3.1.9 m.16371 sp TIMP3_CHICK 33.775 151 92 4 6 152 10 156 1.40E-17 80.1 TIMP3_CHICK reviewed Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) 212 negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] GO:0002020; GO:0005578; GO:0005615; GO:0008191; GO:0010033; GO:0043086; GO:0046872; GO:0051045 0 0 0 PF00965; P50429 CHOYP_BRAFLDRAFT_206907.1.11 m.4114 sp ARSB_MOUSE 42.254 497 243 9 21 479 42 532 1.40E-135 404 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; P61023 CHOYP_CHP1.1.2 m.895 sp CHP1_RAT 69.898 196 52 2 45 234 1 195 1.40E-91 270 CHP1_RAT reviewed Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) Chp1 Chp Rattus norvegicus (Rat) 195 calcium ion regulated exocytosis [GO:0017156]; calcium-mediated signaling [GO:0019722]; cellular response to acidic pH [GO:0071468]; cytoplasmic microtubule organization [GO:0031122]; membrane docking [GO:0022406]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; microtubule bundle formation [GO:0001578]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein transport [GO:0051222]; positive regulation of sodium:proton antiporter activity [GO:0032417]; protein export from nucleus [GO:0006611]; protein oligomerization [GO:0051259]; protein stabilization [GO:0050821]; regulation of intracellular pH [GO:0051453]; regulation of neuron death [GO:1901214] GO:0000139; GO:0001578; GO:0001933; GO:0004860; GO:0005215; GO:0005509; GO:0005634; GO:0005737; GO:0005783; GO:0005793; GO:0005829; GO:0005886; GO:0005925; GO:0006469; GO:0006611; GO:0008017; GO:0010923; GO:0015630; GO:0017156; GO:0019722; GO:0019900; GO:0022406; GO:0030133; GO:0031122; GO:0031397; GO:0031953; GO:0032088; GO:0032417; GO:0042308; GO:0048306; GO:0050821; GO:0051222; GO:0051259; GO:0051453; GO:0060050; GO:0061024; GO:0061025; GO:0070062; GO:0070885; GO:0071468; GO:0090314; GO:1901214 0 0 0 PF13499; P80109 CHOYP_GPLD1.1.1 m.34204 sp PHLD_BOVIN 34.762 840 492 25 18 833 11 818 1.40E-141 443 PHLD_BOVIN reviewed Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) 839 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytolysis [GO:0045919]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633] GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0005578; GO:0005615; GO:0005737; GO:0006507; GO:0008285; GO:0008286; GO:0009749; GO:0010595; GO:0010694; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0032869; GO:0034364; GO:0035690; GO:0035774; GO:0043065; GO:0043231; GO:0045919; GO:0046470; GO:0051044; GO:0051047; GO:0070633; GO:0071277; GO:0071397; GO:0071401; GO:0071467; GO:1900076 0 0 0 PF01839;PF00882; P98110 CHOYP_SELE.2.2 m.50343 sp LYAM2_PIG 25.915 328 212 10 291 609 133 438 1.40E-25 114 LYAM2_PIG reviewed E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE Sus scrofa (Pig) 484 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246 0 0 0 PF00059;PF00084; Q01484 CHOYP_AAEL_AAEL014742.5.8 m.54523 sp ANK2_HUMAN 33.054 717 443 2 1 680 69 785 1.40E-115 386 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q05974 CHOYP_RAB1A.3.3 m.29674 sp RAB1A_LYMST 57.5 200 78 3 2 196 7 204 1.40E-80 241 RAB1A_LYMST reviewed Ras-related protein Rab-1A RAB1A Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 205 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005783; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00071; Q17RM4 CHOYP_BRAFLDRAFT_89287.2.4 m.8375 sp CC142_HUMAN 30.982 326 176 11 2 299 441 745 1.40E-31 127 CC142_HUMAN reviewed Coiled-coil domain-containing protein 142 CCDC142 PSEC0243 Homo sapiens (Human) 750 0 0 0 0 0 0 Q1ZXD6 CHOYP_NEMVEDRAFT_V1G199564.2.6 m.38372 sp ROCO5_DICDI 25.796 314 181 13 493 800 1337 1604 1.40E-15 86.7 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q28CQ7 CHOYP_LOC577640.1.1 m.56393 sp SUV92_XENTR 62.626 198 72 1 4 201 197 392 1.40E-85 266 SUV92_XENTR reviewed Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.43) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) suv39h2 TEgg055l20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 406 "cell cycle [GO:0007049]; cell differentiation [GO:0030154]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000775; GO:0005634; GO:0006351; GO:0006355; GO:0007049; GO:0008270; GO:0018024; GO:0030154 0 0 0 PF00385;PF05033;PF00856; Q28FK7 CHOYP_ACYP2.1.1 m.1087 sp ACYP1_XENTR 57.292 96 41 0 1 96 1 96 1.40E-36 122 ACYP1_XENTR reviewed Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphate phosphohydrolase 1) acyp1 TNeu074n10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 98 0 GO:0003998 0 0 0 PF00708; Q32KL8 CHOYP_LOC100377392.3.4 m.26363 sp TBATA_BOVIN 30.62 258 108 10 35 282 59 255 1.40E-21 98.2 TBATA_BOVIN reviewed "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)" TBATA SPATIAL Bos taurus (Bovine) 333 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005829; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q460N5 CHOYP_LOC100487912.1.3 m.14586 sp PAR14_HUMAN 32.222 360 235 4 29 385 806 1159 1.40E-50 186 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q502M6 CHOYP_LOC100639010.5.9 m.42714 sp ANR29_DANRE 35.678 199 127 1 1 199 47 244 1.40E-34 127 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q56K03 CHOYP_LOC100533291.1.7 m.2058 sp RL27A_BOVIN 74.359 117 29 1 12 127 22 138 1.40E-60 186 RL27A_BOVIN reviewed 60S ribosomal protein L27a RPL27A Bos taurus (Bovine) 148 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00828; Q5RDD2 CHOYP_ORC1.1.2 m.17178 sp PR38A_PONAB 73.593 231 55 2 1 226 1 230 1.40E-116 342 PR38A_PONAB reviewed Pre-mRNA-splicing factor 38A PRPF38A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 312 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0008380 0 0 0 PF03371;PF12871; Q5RDD2 CHOYP_PR38A.1.1 m.55190 sp PR38A_PONAB 73.593 231 55 2 15 240 1 230 1.40E-116 342 PR38A_PONAB reviewed Pre-mRNA-splicing factor 38A PRPF38A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 312 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0008380 0 0 0 PF03371;PF12871; Q5XGG2 CHOYP_LOC101077208.1.1 m.9948 sp TRUB2_XENTR 33.673 196 125 2 109 304 100 290 1.40E-37 139 TRUB2_XENTR reviewed Probable tRNA pseudouridine synthase 2 (EC 5.4.99.-) trub2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 325 pseudouridine synthesis [GO:0001522]; tRNA processing [GO:0008033] GO:0001522; GO:0003723; GO:0008033; GO:0009982 0 0 0 PF01509; Q5ZHN4 CHOYP_LOC100374553.1.1 m.11018 sp XRP2_CHICK 49.451 364 167 6 33 386 1 357 1.40E-130 381 XRP2_CHICK reviewed Protein XRP2 RP2 RCJMB04_35c24 Gallus gallus (Chicken) 357 cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; post-Golgi vesicle-mediated transport [GO:0006892] GO:0000902; GO:0005096; GO:0005525; GO:0005737; GO:0005794; GO:0005814; GO:0005886; GO:0006892; GO:0007010; GO:0031410; GO:0036064; GO:0070062; GO:1990075 0 0 0 PF07986; Q5ZIJ0 CHOYP_LOC100649368.1.1 m.13106 sp BUD13_CHICK 42.857 287 134 8 86 361 292 559 1.40E-47 172 BUD13_CHICK reviewed BUD13 homolog BUD13 RCJMB04_25m15 Gallus gallus (Chicken) 559 0 0 0 0 0 PF09736; Q5ZLA6 CHOYP_MYO1C.1.3 m.534 sp MYO1C_CHICK 46.392 194 95 2 1 192 722 908 1.40E-53 186 MYO1C_CHICK reviewed Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) MYO1C RCJMB04_6o17 Gallus gallus (Chicken) 1028 0 GO:0001726; GO:0003774; GO:0005524; GO:0016023; GO:0016459; GO:0060171 0 0 0 PF00063;PF06017; Q5ZME2 CHOYP_MDHC.1.1 m.57053 sp MDHC_CHICK 71.429 329 92 2 1 328 1 328 1.40E-164 464 MDHC_CHICK reviewed "Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase)" MDH1 RCJMB04_2g5 Gallus gallus (Chicken) 334 carbohydrate metabolic process [GO:0005975]; malate metabolic process [GO:0006108]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; tricarboxylic acid cycle [GO:0006099]; xenophagy [GO:0098792] GO:0002230; GO:0005615; GO:0005739; GO:0005813; GO:0005975; GO:0006099; GO:0006108; GO:0030060; GO:0043209; GO:0070062; GO:0098779; GO:0098792 0 0 cd01336; PF02866;PF00056; Q62348 CHOYP_BRAFLDRAFT_114633.1.1 m.49577 sp TSN_MOUSE 55.814 215 95 0 10 224 3 217 1.40E-89 266 TSN_MOUSE reviewed Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) (Testis/brain RNA-binding protein) (TB-RBP) Tsn Mus musculus (Mouse) 228 0 GO:0003723; GO:0003729; GO:0004519; GO:0005634; GO:0005737; GO:0043565 0 0 0 PF01997; Q69ZR2 CHOYP_BRAFLDRAFT_120990.7.18 m.46079 sp HECD1_MOUSE 34.653 101 62 2 375 471 1278 1378 1.40E-07 58.5 HECD1_MOUSE reviewed E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1) (Protein open mind) Hectd1 Kiaa1131 Opm Mus musculus (Mouse) 2618 aorta development [GO:0035904]; embryonic placenta development [GO:0001892]; heart valve development [GO:0003170]; natural killer cell differentiation [GO:0001779]; negative regulation of protein localization to plasma membrane [GO:1903077]; neural tube closure [GO:0001843]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spongiotrophoblast differentiation [GO:0060708]; trophoblast giant cell differentiation [GO:0060707]; ventricular septum development [GO:0003281] GO:0001779; GO:0001843; GO:0001892; GO:0003170; GO:0003281; GO:0005634; GO:0005737; GO:0016874; GO:0035904; GO:0042787; GO:0046872; GO:0051865; GO:0060707; GO:0060708; GO:0061630; GO:0070534; GO:1903077 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF00632;PF06701;PF07738; Q6ZWJ8 CHOYP_BRAFLDRAFT_74063.3.5 m.41590 sp KCP_HUMAN 26.79 433 200 24 91 444 246 640 1.40E-16 86.3 KCP_HUMAN reviewed Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) KCP CRIM2 KCP1 Homo sapiens (Human) 1503 positive regulation of BMP signaling pathway [GO:0030513] GO:0005615; GO:0030513 0 0 0 PF00093;PF00094; Q7Z7G8 CHOYP_LOC100735249.1.2 m.31956 sp VP13B_HUMAN 27.363 603 361 21 22 580 1050 1619 1.40E-55 207 VP13B_HUMAN reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) 4022 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q7ZV82 CHOYP_LOC100373506.1.8 m.5705 sp RL27_DANRE 80.8 125 24 0 1 125 1 125 1.40E-70 211 RL27_DANRE reviewed 60S ribosomal protein L27 rpl27 zgc:56171 Danio rerio (Zebrafish) (Brachydanio rerio) 136 erythrocyte differentiation [GO:0030218]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625; GO:0030218 0 0 0 PF00467;PF01777; Q805B4 CHOYP_BRAFLDRAFT_69266.1.1 m.61431 sp TISDB_XENLA 50 210 73 9 1 184 1 204 1.40E-49 174 TISDB_XENLA reviewed "Zinc finger protein 36, C3H1 type-like 2-B (CCCH zinc finger protein 3-B) (XC3H-3b)" zfp36l2-B zfp36l2 Xenopus laevis (African clawed frog) 364 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; MAPK cascade [GO:0000165]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of stem cell differentiation [GO:2000737]; nephron tubule development [GO:0072080]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; pronephric nephron tubule development [GO:0039020]; pronephros development [GO:0048793]; regulation of mRNA stability [GO:0043488]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]" GO:0000165; GO:0000288; GO:0003677; GO:0005634; GO:0005737; GO:0006402; GO:0030097; GO:0031086; GO:0035019; GO:0035925; GO:0039020; GO:0043488; GO:0044344; GO:0045599; GO:0046872; GO:0048103; GO:0048793; GO:0060216; GO:0061158; GO:0070371; GO:0071356; GO:0071364; GO:0071385; GO:0071560; GO:0072080; GO:0097011; GO:1900153; GO:1904628; GO:2000737 0 0 0 PF04553;PF00642; Q86Y13 CHOYP_LOC100372716.5.10 m.31370 sp DZIP3_HUMAN 31.461 89 59 1 67 153 452 540 1.40E-07 55.8 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8I8U7 CHOYP_TRRAP.2.2 m.19911 sp TRA1_DROME 48.232 311 122 9 2 310 453 726 1.40E-73 249 TRA1_DROME reviewed Transcription-associated protein 1 (dTRA1) Nipped-A Tra1 CG2905 Drosophila melanogaster (Fruit fly) 3803 "DNA repair [GO:0006281]; histone acetylation [GO:0016573]; histone exchange [GO:0043486]; histone H3 acetylation [GO:0043966]; mitotic cytokinesis [GO:0000281]; phagocytosis [GO:0006909]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; wing disc pattern formation [GO:0035222]" GO:0000123; GO:0000124; GO:0000281; GO:0005634; GO:0005700; GO:0005703; GO:0005737; GO:0005875; GO:0006281; GO:0006351; GO:0006355; GO:0006909; GO:0016301; GO:0016573; GO:0035222; GO:0035267; GO:0043486; GO:0043966; GO:0045747 0 0 0 PF02259;PF02260;PF00454; Q8IT98 CHOYP_RS18.9.11 m.43086 sp RS18_ARGIR 77.852 149 32 1 1 149 1 148 1.40E-84 248 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8JZP9 CHOYP_PHUM_PHUM215460.1.1 m.33815 sp GA2L1_MOUSE 48.208 307 109 9 45 320 14 301 1.40E-83 293 GA2L1_MOUSE reviewed GAS2-like protein 1 (Growth arrest-specific protein 2-like 1) Gas2l1 Mus musculus (Mouse) 678 cell cycle arrest [GO:0007050]; cellular response to starvation [GO:0009267]; cellular response to thyroid hormone stimulus [GO:0097067]; microtubule bundle formation [GO:0001578]; negative regulation of cell growth [GO:0030308]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of gene expression [GO:0010629]; negative regulation of microtubule depolymerization [GO:0007026]; regulation of cell cycle [GO:0051726] GO:0001578; GO:0005737; GO:0005856; GO:0007026; GO:0007050; GO:0008017; GO:0008093; GO:0009267; GO:0010629; GO:0030308; GO:0045647; GO:0046966; GO:0051726; GO:0097067 0 0 0 PF00307;PF02187; Q8K561 CHOYP_TRIADDRAFT_63672.1.1 m.22089 sp OTOAN_MOUSE 26.531 196 137 5 158 350 841 1032 1.40E-11 70.1 OTOAN_MOUSE reviewed Otoancorin Otoa Mus musculus (Mouse) 1137 cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226] GO:0005578; GO:0007160; GO:0007605; GO:0009986; GO:0016324; GO:0019226; GO:0031225 0 0 0 0 Q8QZX5 CHOYP_BRAFLDRAFT_76640.1.1 m.62315 sp LSM10_MOUSE 41.584 101 59 0 15 115 6 106 1.40E-20 84.7 LSM10_MOUSE reviewed U7 snRNA-associated Sm-like protein LSm10 Lsm10 Mus musculus (Mouse) 122 mRNA processing [GO:0006397]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; RNA splicing [GO:0008380] GO:0005634; GO:0005683; GO:0006397; GO:0008380; GO:0015030; GO:0017069; GO:0071208; GO:0071209; GO:1900087 0 0 0 PF01423; Q8R116 CHOYP_LOC100313685.1.1 m.8411 sp NOTUM_MOUSE 48.684 380 180 6 27 403 59 426 1.40E-135 407 NOTUM_MOUSE reviewed Palmitoleoyl-protein carboxylesterase NOTUM (EC 3.1.1.98) Notum Mus musculus (Mouse) 503 negative regulation of Wnt signaling pathway [GO:0030178]; protein depalmitoleylation [GO:1990697]; Wnt signaling pathway [GO:0016055] GO:0005576; GO:0016055; GO:0030178; GO:1990697; GO:1990699 0 0 0 PF03283; Q8WQI5 CHOYP_RS8.6.14 m.38092 sp RS8_SPOFR 72.5 200 53 1 22 221 1 198 1.40E-103 301 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q8WZ42 CHOYP_BRAFLDRAFT_95022.1.1 m.38082 sp TITIN_HUMAN 31.429 140 82 6 24 155 8596 8729 1.40E-08 57.8 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q8WZ42 CHOYP_HMCN1.39.44 m.61047 sp TITIN_HUMAN 26.812 690 455 26 268 953 7019 7662 1.40E-41 172 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q93YS4 CHOYP_LOC100166121.1.1 m.52567 sp AB22G_ARATH 34.264 645 344 15 18 645 164 745 1.40E-114 363 AB22G_ARATH reviewed ABC transporter G family member 22 (ABC transporter ABCG.22) (AtABCG22) (White-brown complex homolog protein 23) (AtWBC23) ABCG22 WBC23 At5g06530 F15M7.6 Arabidopsis thaliana (Mouse-ear cress) 751 response to water deprivation [GO:0009414]; transpiration [GO:0010148] GO:0005524; GO:0005886; GO:0009414; GO:0010148; GO:0016021; GO:0042626 0 0 0 PF01061;PF00005; Q96AT9 CHOYP_LOC100370410.1.1 m.24212 sp RPE_HUMAN 64.384 219 77 1 10 227 5 223 1.40E-105 306 RPE_HUMAN reviewed Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase) RPE HUSSY-17 Homo sapiens (Human) 228 "carbohydrate metabolic process [GO:0005975]; cellular carbohydrate metabolic process [GO:0044262]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]" GO:0004750; GO:0005829; GO:0005975; GO:0006098; GO:0009052; GO:0019323; GO:0042802; GO:0042803; GO:0044262; GO:0046872; GO:0070062 0 0 cd00429; PF00834; Q96LL9 CHOYP_HOOK3.1.1 m.14457 sp DJC30_HUMAN 43.59 78 42 2 27 102 51 128 1.40E-13 66.6 DJC30_HUMAN reviewed DnaJ homolog subfamily C member 30 (Williams-Beuren syndrome chromosomal region 18 protein) DNAJC30 WBSCR18 Homo sapiens (Human) 226 0 GO:0005739 0 0 cd06257; PF00226; Q98TR7 CHOYP_RS16.2.5 m.36553 sp RS16_HETFO 89.655 145 15 0 5 149 2 146 1.40E-92 267 RS16_HETFO reviewed 40S ribosomal protein S16 rps16 Heteropneustes fossilis (Stinging catfish) 146 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00380; Q98TR7 CHOYP_RS16.4.5 m.64177 sp RS16_HETFO 89.655 145 15 0 5 149 2 146 1.40E-92 267 RS16_HETFO reviewed 40S ribosomal protein S16 rps16 Heteropneustes fossilis (Stinging catfish) 146 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00380; Q99NE9 CHOYP_PBX4.2.2 m.18055 sp PBX4_MOUSE 27.211 147 91 3 89 227 134 272 1.40E-12 70.9 PBX4_MOUSE reviewed Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4) Pbx4 Mus musculus (Mouse) 378 "positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0001741; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0043565; GO:0045893 0 0 0 PF00046;PF03792; Q9ESN6 CHOYP_LOC100374741.21.83 m.20609 sp TRIM2_MOUSE 28.713 202 125 9 321 516 515 703 1.40E-10 67.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NFT7 CHOYP_AAEL_AAEL009387.1.1 m.66163 sp HXK2_DROME 47.717 438 227 2 69 504 42 479 1.40E-149 440 HXK2_DROME reviewed Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) 486 cellular glucose homeostasis [GO:0001678]; fructose metabolic process [GO:0006000]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; mannose metabolic process [GO:0006013] GO:0001678; GO:0004340; GO:0004396; GO:0005524; GO:0005536; GO:0005829; GO:0006000; GO:0006006; GO:0006013; GO:0006096; GO:0008865; GO:0019158 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF00349;PF03727; Q9NUV9 CHOYP_LOC100732570.1.2 m.4387 sp GIMA4_HUMAN 37.143 210 128 2 43 252 30 235 1.40E-42 152 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9P273 CHOYP_DERE_GG24368.1.1 m.28488 sp TEN3_HUMAN 30.045 223 124 13 157 369 536 736 1.40E-14 79 TEN3_HUMAN reviewed Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) TENM3 KIAA1455 ODZ3 TNM3 Homo sapiens (Human) 2699 camera-type eye morphogenesis [GO:0048593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of neuron projection development [GO:0010976]; self proteolysis [GO:0097264]; signal transduction [GO:0007165] GO:0007156; GO:0007165; GO:0010976; GO:0016020; GO:0016021; GO:0030424; GO:0042803; GO:0046982; GO:0048593; GO:0097264 0 0 0 PF06484;PF15636; Q9QY94 CHOYP_TRIADDRAFT_49883.1.1 m.29857 sp GLNA_ACOCA 36.198 384 218 8 6 389 14 370 1.40E-72 234 GLNA_ACOCA reviewed Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase) GLUL Acomys cahirinus (Cairo spiny mouse) 373 glutamine biosynthetic process [GO:0006542] GO:0004351; GO:0004356; GO:0005524; GO:0005739; GO:0006542 0 0 0 PF00120;PF03951; Q9R1R2 CHOYP_BRAFLDRAFT_87294.2.6 m.32729 sp TRIM3_MOUSE 27.407 135 89 3 45 175 614 743 1.40E-09 60.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U6M0 CHOYP_PHUM_PHUM075600.1.1 m.35072 sp ECSIT_DROME 34.185 313 200 5 125 433 63 373 1.40E-62 211 ECSIT_DROME reviewed "Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial" ECSIT CG10610 Drosophila melanogaster (Fruit fly) 409 innate immune response [GO:0045087]; regulation of oxidoreductase activity [GO:0051341] GO:0005634; GO:0005737; GO:0005739; GO:0016651; GO:0045087; GO:0051341 0 0 0 PF06239;PF14784; Q9UM73 CHOYP_LOC100542012.1.1 m.16395 sp ALK_HUMAN 46.656 598 295 9 4 600 824 1398 1.40E-143 460 ALK_HUMAN reviewed ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) ALK Homo sapiens (Human) 1620 activation of MAPK activity [GO:0000187]; cell proliferation [GO:0008283]; neuron development [GO:0048666]; phosphorylation [GO:0016310]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000187; GO:0004704; GO:0004713; GO:0004714; GO:0005524; GO:0005622; GO:0005887; GO:0007165; GO:0007169; GO:0008283; GO:0016310; GO:0042802; GO:0042981; GO:0043234; GO:0046777; GO:0048666; GO:0051092; GO:0070062 0 0 cd06263; PF00629;PF07714; Q9VCA8 CHOYP_LOC100637968.11.12 m.52303 sp ANKHM_DROME 35.165 273 149 7 788 1045 559 818 1.40E-25 119 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; A4IF63 CHOYP_TRIM2.51.59 m.55804 sp TRIM2_BOVIN 22.968 283 194 7 94 362 472 744 1.41E-10 66.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7Y2X0 CHOYP_BRAFLDRAFT_117177.1.1 m.19108 sp SC6A5_XENLA 43.85 187 105 0 21 207 573 759 1.41E-50 179 SC6A5_XENLA reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) 790 0 GO:0005328; GO:0005886; GO:0016021; GO:0046872 0 0 0 PF00209; A9JSB3 CHOYP_BRAFLDRAFT_126681.1.1 m.2014 sp APC15_XENTR 61.667 60 23 0 1 60 1 60 1.41E-17 74.7 APC15_XENTR reviewed Anaphase-promoting complex subunit 15 (APC15) anapc15 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 120 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] GO:0005680; GO:0007067; GO:0051301; GO:0090266 0 0 0 PF15243; G9JJU2 CHOYP_GPX3.2.2 m.29168 sp GPX_PROCL 49.689 161 77 4 40 197 9 168 1.41E-44 149 GPX_PROCL reviewed Glutathione peroxidase (PcGPx) (Se-PcGPx) (EC 1.11.1.9) GPx Procambarus clarkii (Red swamp crayfish) 172 response to oxidative stress [GO:0006979] GO:0004602; GO:0006979 0 0 cd00340; PF00255; I1VZH0 CHOYP_LOC100374981.10.16 m.60863 sp RN207_RABIT 23.902 205 131 6 16 213 103 289 1.41E-09 63.9 RN207_RABIT reviewed RING finger protein 207 RNF207 Oryctolagus cuniculus (Rabbit) 594 0 GO:0005737; GO:0008270 0 0 0 PF00643; O01391 CHOYP_UCHL.1.1 m.29303 sp UCHL_APLCA 54.93 213 94 1 1 211 1 213 1.41E-79 240 UCHL_APLCA reviewed Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (Ubiquitin thioesterase) UCH Aplysia californica (California sea hare) 214 ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005737; GO:0006511 0 0 0 PF01088; O01761 CHOYP_LOAG_01021.1.4 m.1827 sp UNC89_CAEEL 28.261 230 142 5 39 249 5599 5824 1.41E-16 87.4 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O14522 CHOYP_CPIPJ_CPIJ002121.2.3 m.31920 sp PTPRT_HUMAN 41.341 179 102 2 555 732 869 1045 1.41E-32 139 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O44437 CHOYP_PABP2.1.1 m.12769 sp SMD3_DROME 84.112 107 15 1 1 105 1 107 1.41E-61 188 SMD3_DROME reviewed Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) SmD3 guf2 CG8427 Drosophila melanogaster (Fruit fly) 151 "central nervous system development [GO:0007417]; lymph gland development [GO:0048542]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; neuron differentiation [GO:0030182]; peripheral nervous system development [GO:0007422]; pole plasm oskar mRNA localization [GO:0045451]; regulation of glucose metabolic process [GO:0010906]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]" GO:0000243; GO:0000245; GO:0000387; GO:0000398; GO:0003723; GO:0005634; GO:0005681; GO:0005682; GO:0005685; GO:0005686; GO:0005687; GO:0005689; GO:0007052; GO:0007067; GO:0007417; GO:0007422; GO:0007517; GO:0010906; GO:0030182; GO:0030532; GO:0034715; GO:0034719; GO:0044822; GO:0045451; GO:0045495; GO:0048542; GO:0071010; GO:0071011; GO:0071013; GO:0097526 0 0 0 PF01423; O57429 CHOYP_LOC100186834.2.2 m.58051 sp UBP2_CHICK 26.781 351 193 13 835 1142 20 349 1.41E-17 89.4 UBP2_CHICK reviewed Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Gallus gallus (Chicken) 357 protein deubiquitination [GO:0016579]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0016579; GO:0046872; GO:0048471; GO:0048511 0 0 0 PF00443; O75382 CHOYP_LOC100374342.6.19 m.25489 sp TRIM3_HUMAN 30.508 118 75 4 19 135 114 225 1.41E-09 64.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P05945 CHOYP_MLE.4.9 m.38686 sp MLE_TODPA 58.784 148 59 2 7 153 8 154 1.41E-56 177 MLE_TODPA reviewed "Myosin catalytic light chain LC-1, mantle muscle" 0 Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) 160 0 GO:0005509; GO:0016459 0 0 0 PF13405; P06605 CHOYP_LOC100366892.1.3 m.17709 sp TBA3_DROME 99.301 143 1 0 1 143 1 143 1.41E-101 301 TBA3_DROME reviewed Tubulin alpha-3 chain alphaTub84D TubA84D CG2512 Drosophila melanogaster (Fruit fly) 450 microtubule-based process [GO:0007017]; mitotic cytokinesis [GO:0000281] GO:0000281; GO:0003924; GO:0005200; GO:0005525; GO:0005811; GO:0005874; GO:0007017; GO:0017022; GO:0048471 0 0 0 PF00091;PF03953; P08842 CHOYP_STS.1.1 m.35785 sp STS_HUMAN 42.701 548 305 6 27 568 26 570 1.41E-159 471 STS_HUMAN reviewed Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase) STS ARSC1 Homo sapiens (Human) 583 epidermis development [GO:0008544]; female pregnancy [GO:0007565]; glycosphingolipid metabolic process [GO:0006687]; learning or memory [GO:0007611]; positive regulation of cell proliferation [GO:0008284]; post-translational protein modification [GO:0043687]; response to estrogen [GO:0043627]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; response to pH [GO:0009268]; skin development [GO:0043588]; steroid catabolic process [GO:0006706] GO:0004773; GO:0005635; GO:0005764; GO:0005768; GO:0005783; GO:0005788; GO:0005789; GO:0005794; GO:0005886; GO:0006687; GO:0006706; GO:0007565; GO:0007611; GO:0008284; GO:0008484; GO:0008544; GO:0009268; GO:0014070; GO:0016020; GO:0016021; GO:0043231; GO:0043434; GO:0043588; GO:0043627; GO:0043687; GO:0046872 0 0 0 PF00884; P10394 CHOYP_LOC100330808.1.2 m.18753 sp POL4_DROME 27.115 520 313 16 1 484 706 1195 1.41E-35 147 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P15870 CHOYP_LOC100885792.1.3 m.38273 sp H1D_STRPU 57.895 76 30 1 43 118 32 105 1.41E-20 86.7 H1D_STRPU reviewed Histone H1-delta 0 Strongylocentrotus purpuratus (Purple sea urchin) 185 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; P18503 CHOYP_BRAFLDRAFT_67696.3.3 m.54584 sp CAS4_EPHMU 29.577 142 86 3 100 241 186 313 1.41E-08 58.9 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P20273 CHOYP_CBR-IGCM-1.1.1 m.25588 sp CD22_HUMAN 24.103 390 258 14 47 414 148 521 1.41E-17 88.6 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P20273 CHOYP_IGFN3-4.1.2 m.23736 sp CD22_HUMAN 24.52 469 302 17 80 519 148 593 1.41E-21 104 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P56677 CHOYP_LOC752921.2.2 m.54592 sp ST14_MOUSE 34.532 139 75 5 56 190 360 486 1.41E-10 65.9 ST14_MOUSE reviewed Suppressor of tumorigenicity 14 protein homolog (EC 3.4.21.109) (Epithin) (Serine protease 14) St14 Prss14 Mus musculus (Mouse) 855 cell migration [GO:0016477]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; proteolysis [GO:0006508] GO:0001843; GO:0004252; GO:0005576; GO:0005615; GO:0005887; GO:0006508; GO:0008236; GO:0016323; GO:0016477; GO:0019897; GO:0030216; GO:0060672; GO:0070062 0 0 cd00190; PF00431;PF00057;PF01390;PF00089; P59222 CHOYP_LOC100489801.1.1 m.51126 sp SREC2_MOUSE 35.976 164 76 8 188 344 261 402 1.41E-13 76.3 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P59889 CHOYP_S39A3.1.1 m.51419 sp S39A1_DANRE 30.392 306 166 7 23 310 25 301 1.41E-31 122 S39A1_DANRE reviewed Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1) slc39a1 zip1 sb:cb629 zgc:111852 Danio rerio (Zebrafish) (Brachydanio rerio) 302 zinc II ion transmembrane transport [GO:0071577]; zinc II ion transport [GO:0006829] GO:0005385; GO:0005886; GO:0006829; GO:0008270; GO:0016021; GO:0071577 0 0 0 PF02535; P61025 CHOYP_BRAFLDRAFT_59154.3.3 m.53255 sp CKS1_MOUSE 79.73 74 14 1 22 94 1 74 1.41E-38 127 CKS1_MOUSE reviewed Cyclin-dependent kinases regulatory subunit 1 (CKS-1) (Sid 1334) Cks1b Cks1 Sid1334 Mus musculus (Mouse) 79 "cell division [GO:0051301]; cell proliferation [GO:0008283]; mitotic cell cycle phase transition [GO:0044772]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000307; GO:0006355; GO:0007346; GO:0008283; GO:0019005; GO:0019901; GO:0042393; GO:0043130; GO:0044772; GO:0045737; GO:0045893; GO:0051301; GO:0061575 0 0 0 PF01111; P86854 CHOYP_BRAFLDRAFT_223290.2.2 m.30918 sp PLCL_MYTGA 32.456 114 68 3 355 465 25 132 1.41E-14 74.7 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P98160 CHOYP_HMCN1.33.44 m.58938 sp PGBM_HUMAN 23.536 871 528 36 33 865 2627 3397 1.41E-31 139 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; Q04462 CHOYP_LOC101158795.1.1 m.18307 sp SYVC_RAT 39.606 457 263 7 2 447 809 1263 1.41E-99 327 SYVC_RAT reviewed Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) Vars Vars2 Rattus norvegicus (Rat) 1264 valyl-tRNA aminoacylation [GO:0006438] GO:0002161; GO:0004832; GO:0005524; GO:0005739; GO:0006438 0 0 cd07962; PF08264;PF00043;PF00133; Q05695 CHOYP_NFASC.1.1 m.19042 sp L1CAM_RAT 22.519 262 187 7 2 259 111 360 1.41E-15 79.7 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q05A80 CHOYP_LOC100698726.4.8 m.23014 sp CAPR2_MOUSE 30.882 136 82 5 161 293 902 1028 1.41E-08 59.3 CAPR2_MOUSE reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) 1031 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q06852 CHOYP_contig_053654 m.64257 sp SLAP1_CLOTH 56.425 179 46 14 2 152 1480 1654 1.41E-07 53.1 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0P4I1 CHOYP_CEP44.1.2 m.16237 sp CEP44_XENTR 47.967 123 64 0 1 123 1 123 1.41E-31 129 CEP44_XENTR reviewed Centrosomal protein of 44 kDa (Cep44) cep44 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 385 0 GO:0000922; GO:0005737; GO:0005813; GO:0030496 0 0 0 PF15007; Q1L9A2 CHOYP_LOC100163297.1.1 m.40113 sp OPA3_DANRE 38.095 147 88 2 8 154 2 145 1.41E-26 103 OPA3_DANRE reviewed Optic atrophy 3 protein homolog opa3 si:dkey-12o15.3 Danio rerio (Zebrafish) (Brachydanio rerio) 157 locomotory behavior [GO:0007626]; musculoskeletal movement [GO:0050881]; regulation of buoyancy [GO:0031413]; regulation of lipid metabolic process [GO:0019216] GO:0005739; GO:0007626; GO:0019216; GO:0031413; GO:0050881 0 0 0 PF07047; Q1MSJ5 CHOYP_CSPP1.11.14 m.54546 sp CSPP1_HUMAN 35.077 650 319 21 895 1490 625 1225 1.41E-46 187 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q28DR4 CHOYP_LOC100903522.3.3 m.17387 sp H4_XENTR 100 103 0 0 7 109 1 103 1.41E-67 201 H4_XENTR reviewed Histone H4 TGas006m08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 103 "DNA-templated transcription, initiation [GO:0006352]; nucleosome assembly [GO:0006334]" GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0006352 0 0 0 0 Q2M2T9 CHOYP_ISCW_ISCW010143.1.3 m.17398 sp TERB2_BOVIN 26.728 217 125 5 6 207 1 198 1.41E-14 72.8 TERB2_BOVIN reviewed Telomere repeats-binding bouquet formation protein 2 TERB2 Bos taurus (Bovine) 221 meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; synapsis [GO:0007129] GO:0000784; GO:0005637; GO:0007129; GO:0045141; GO:0070197 0 0 0 PF15101; Q49LS4 CHOYP_PHUM_PHUM225050.1.1 m.9233 sp XKR4_PANTR 36.09 266 165 2 78 339 258 522 1.41E-45 179 XKR4_PANTR reviewed XK-related protein 4 XKR4 XRG4 Pan troglodytes (Chimpanzee) 650 0 GO:0016020; GO:0016021 0 0 0 PF09815; Q4LDE5 CHOYP_LOC100372820.1.1 m.34086 sp SVEP1_HUMAN 30.726 179 98 6 855 1027 1002 1160 1.41E-09 66.6 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4R8M9 CHOYP_LOC100176891.1.1 m.16033 sp GTSF1_MACFA 36.19 105 59 3 8 110 10 108 1.41E-14 73.6 GTSF1_MACFA reviewed Gametocyte-specific factor 1 (Protein FAM112B) GTSF1 FAM112B QtsA-12026 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 167 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0005737; GO:0007283; GO:0030154; GO:0046872 0 0 0 PF05253; Q4UMH6 CHOYP_AASI_1435.14.35 m.35604 sp Y381_RICFE 23.797 395 238 11 289 683 688 1019 1.41E-16 88.2 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q54KA7 CHOYP_AFUA_1G01020.5.50 m.14041 sp SECG_DICDI 35.948 306 162 1 3 274 170 475 1.41E-48 176 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q58CU2 CHOYP_AGAP_AGAP004136.2.3 m.31360 sp E41L5_BOVIN 58.134 418 165 2 31 440 40 455 1.41E-168 490 E41L5_BOVIN reviewed Band 4.1-like protein 5 EPB41L5 Bos taurus (Bovine) 502 0 GO:0005737; GO:0005856; GO:0005912; GO:0019898 0 0 0 PF08736;PF09380;PF00373;PF09379; Q5F478 CHOYP_LOC100197555.3.7 m.41188 sp ANR44_CHICK 34.679 421 266 2 26 441 24 440 1.41E-70 243 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5R1U3 CHOYP_LOC101067698.1.2 m.26952 sp CYTA3_DICDI 39 100 54 3 24 122 1 94 1.41E-15 69.7 CYTA3_DICDI reviewed Cystatin-A3 (VSA745) cpiC DDB_G0277001 Dictyostelium discoideum (Slime mold) 94 hyperosmotic response [GO:0006972]; proteolysis [GO:0006508] GO:0004869; GO:0005737; GO:0006508; GO:0006972 0 0 0 PF00031; Q5R9U9 CHOYP_LOC100367663.1.1 m.10039 sp RWD2B_PONAB 39.51 286 164 5 21 300 37 319 1.41E-74 234 RWD2B_PONAB reviewed RWD domain-containing protein 2B RWDD2B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 319 0 0 0 0 0 PF06544;PF05773; Q5RE15 CHOYP_LOC100372505.2.2 m.26613 sp PSMD8_PONAB 64.906 265 92 1 64 327 25 289 1.41E-118 346 PSMD8_PONAB reviewed 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (Fragment) PSMD8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 289 proteolysis [GO:0006508] GO:0005838; GO:0006508; GO:0022624 0 0 0 PF10075; Q61189 CHOYP_TM164.1.1 m.8398 sp ICLN_MOUSE 40.476 126 51 4 33 134 108 233 1.41E-12 65.5 ICLN_MOUSE reviewed "Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI)" Clns1a Clci Clcni Mus musculus (Mouse) 236 cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006821; GO:0006884; GO:0034709; GO:0034715; GO:0044822; GO:0046982 0 0 0 0 Q68EK2 CHOYP_CALCR.4.6 m.38626 sp CALRL_DANRE 36.152 343 199 8 116 449 73 404 1.41E-64 219 CALRL_DANRE reviewed Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrla calcrl si:dkey-249o24.2 zgc:100872 Danio rerio (Zebrafish) (Brachydanio rerio) 470 angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; cell surface receptor signaling pathway [GO:0007166]; somitogenesis [GO:0001756] GO:0001525; GO:0001756; GO:0004948; GO:0005886; GO:0007166; GO:0016021; GO:0048844 0 0 0 PF00002;PF02793; Q6NRK9 CHOYP_FA58A.1.1 m.30264 sp FA58A_XENLA 54.751 221 100 0 6 226 21 241 1.41E-86 259 FA58A_XENLA reviewed Cyclin-related protein FAM58A fam58a Xenopus laevis (African clawed frog) 244 0 0 0 0 0 PF00134; Q80ZA4 CHOYP_LOC100373890.1.2 m.27482 sp PKHL1_MOUSE 31.559 526 347 9 2 519 926 1446 1.41E-68 243 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8IYB9 CHOYP_LOC100721364.1.1 m.15879 sp ZN595_HUMAN 40.432 324 179 6 178 499 226 537 1.41E-67 232 ZN595_HUMAN reviewed Zinc finger protein 595 ZNF595 Homo sapiens (Human) 648 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q8IYJ1 CHOYP_CPNE.1.1 m.37754 sp CPNE9_HUMAN 51.899 79 38 0 6 84 9 87 1.41E-20 88.6 CPNE9_HUMAN reviewed Copine-9 (Copine IX) CPNE9 Homo sapiens (Human) 553 positive regulation of dendrite extension [GO:1903861] GO:0005615; GO:0070062; GO:1903861 0 0 0 PF00168;PF07002; Q8K1J6 CHOYP_TRNT1.1.1 m.1512 sp TRNT1_MOUSE 50.49 408 195 3 68 471 27 431 1.41E-138 409 TRNT1_MOUSE reviewed "CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)" Trnt1 Mus musculus (Mouse) 434 tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]; tRNA processing [GO:0008033] GO:0000049; GO:0001680; GO:0004810; GO:0005524; GO:0005622; GO:0005739; GO:0008033; GO:0009022; GO:0042780; GO:0052927; GO:0052928; GO:0052929 0 0 cd05398; PF01743;PF12627; Q8NEP9 CHOYP_ZN181.1.1 m.1945 sp ZN555_HUMAN 28.968 252 173 3 220 469 313 560 1.41E-30 131 ZN555_HUMAN reviewed Zinc finger protein 555 ZNF555 Homo sapiens (Human) 628 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q8R4E0 CHOYP_RL24.5.9 m.43114 sp IRF2_SIGHI 49.55 111 54 1 18 126 2 112 1.41E-32 127 IRF2_SIGHI reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Sigmodon hispidus (Hispid cotton rat) 349 "cell proliferation [GO:0008283]; transcription, DNA-templated [GO:0006351]" GO:0000975; GO:0003700; GO:0005634; GO:0006351; GO:0008283 0 0 0 PF00605; Q95ZJ1 CHOYP_DMOJ_GI18492.1.1 m.8902 sp GALT5_CAEEL 68.513 343 96 3 131 462 97 438 1.41E-169 497 GALT5_CAEEL reviewed Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans 626 protein O-linked glycosylation via threonine [GO:0018243] GO:0000139; GO:0004653; GO:0016021; GO:0018243; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q96F25 CHOYP_ALG14.1.1 m.41943 sp ALG14_HUMAN 47.761 201 102 2 33 231 17 216 1.41E-63 200 ALG14_HUMAN reviewed UDP-N-acetylglucosamine transferase subunit ALG14 homolog ALG14 Homo sapiens (Human) 216 dolichol-linked oligosaccharide biosynthetic process [GO:0006488] GO:0004577; GO:0005789; GO:0006488; GO:0016021; GO:0031965 0 0 0 PF08660; Q96MM6 CHOYP_HS12B.8.14 m.49728 sp HS12B_HUMAN 36.019 211 122 4 1 201 479 686 1.41E-32 126 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96PE7 CHOYP_MCEE.1.1 m.62224 sp MCEE_HUMAN 66 150 48 1 13 159 26 175 1.41E-68 208 MCEE_HUMAN reviewed "Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)" MCEE Homo sapiens (Human) 176 L-methylmalonyl-CoA metabolic process [GO:0046491]; short-chain fatty acid catabolic process [GO:0019626] GO:0004493; GO:0005759; GO:0019626; GO:0046491; GO:0046872 0 0 0 0 Q96RW7 CHOYP_DSEC_GM26472.1.1 m.12920 sp HMCN1_HUMAN 25.969 258 146 9 76 320 2291 2516 1.41E-13 76.6 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96RW7 CHOYP_LOC661200.2.3 m.35208 sp HMCN1_HUMAN 23.906 297 170 12 183 453 2927 3193 1.41E-06 55.5 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96T55 CHOYP_LOC100903082.1.1 m.519 sp KCNKG_HUMAN 37.395 238 145 1 11 248 13 246 1.41E-45 160 KCNKG_HUMAN reviewed Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1) KCNK16 TALK1 Homo sapiens (Human) 309 potassium ion transport [GO:0006813]; stabilization of membrane potential [GO:0030322] GO:0005244; GO:0005267; GO:0005886; GO:0005887; GO:0006813; GO:0022841; GO:0030322 0 0 0 PF07885; Q9C0E4 CHOYP_ISCW_ISCW016695.1.1 m.41903 sp GRIP2_HUMAN 34.848 660 359 18 4 624 182 809 1.41E-95 319 GRIP2_HUMAN reviewed Glutamate receptor-interacting protein 2 (GRIP-2) GRIP2 KIAA1719 Homo sapiens (Human) 1043 0 GO:0005829; GO:0005886 0 0 0 PF00595; Q9D0S4 CHOYP_LOC100749690.2.2 m.33410 sp NEUL2_MOUSE 36.41 195 92 10 1 179 107 285 1.41E-24 99.8 NEUL2_MOUSE reviewed Neuralized-like protein 2 Neurl2 Ozz Mus musculus (Mouse) 285 intracellular signal transduction [GO:0035556]; myofibril assembly [GO:0030239]; protein ubiquitination [GO:0016567]; sarcomere organization [GO:0045214] GO:0005927; GO:0016567; GO:0030239; GO:0030891; GO:0035556; GO:0045214 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07177;PF07525; Q9LVN1 CHOYP_LOC100641843.1.1 m.48151 sp FH13_ARATH 25.542 415 264 11 766 1149 806 1206 1.41E-24 115 FH13_ARATH reviewed Formin-like protein 13 (AtFH13) FH13 At5g58160 MCK7.3 Arabidopsis thaliana (Mouse-ear cress) 1266 0 GO:0004721 0 0 0 PF02181;PF10409; Q9VXK0 CHOYP_DMOJ_GI11203.1.1 m.24977 sp NIPSN_DROME 50.617 243 118 1 65 305 31 273 1.41E-84 258 NIPSN_DROME reviewed Protein NipSnap Nipsnap CG9212 Drosophila melanogaster (Fruit fly) 273 0 0 0 0 0 PF07978; Q9XWD6 CHOYP_LOC100701872.2.7 m.23375 sp CED1_CAEEL 37.069 232 127 11 217 446 591 805 1.41E-23 108 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; Q9Y6R7 CHOYP_CYCMA_4407.3.4 m.55549 sp FCGBP_HUMAN 25.155 322 224 9 103 416 36 348 1.41E-15 84 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A0JM12 CHOYP_MEG10.44.91 m.43430 sp MEG10_XENTR 37.5 248 133 11 22 268 601 827 1.42E-33 134 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A1XQX0 CHOYP_NR1AA.1.1 m.39226 sp NR1AA_DANRE 28.176 866 524 24 2325 3116 486 1327 1.42E-84 313 NR1AA_DANRE reviewed Neurexin-1a (Neurexin Ia-alpha) (Neurexin-1a-alpha) nrxn1a Danio rerio (Zebrafish) (Brachydanio rerio) 1491 cell adhesion [GO:0007155]; sprouting angiogenesis [GO:0002040] GO:0002040; GO:0007155; GO:0016021; GO:0042734; GO:0046872 0 0 0 PF00008;PF02210;PF01034; A3E4D8 CHOYP_SCAM-5.1.1 m.27931 sp CALM_PROMN 38.514 148 89 2 1 148 1 146 1.42E-28 105 CALM_PROMN reviewed Calmodulin (CaM) 0 Prorocentrum minimum (Dinoflagellate) (Exuviaella minima) 149 0 GO:0005509 0 0 0 PF13499; A3KPQ7 CHOYP_TMEM2.4.4 m.28440 sp TMEM2_DANRE 27.35 1064 631 33 53 1034 143 1146 1.42E-99 347 TMEM2_DANRE reviewed Transmembrane protein 2 tmem2 si:dkey-24k20.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1378 atrioventricular valve formation [GO:0003190]; cell migration to the midline involved in heart development [GO:0003318]; heart looping [GO:0001947] GO:0001947; GO:0003190; GO:0003318; GO:0016021 0 0 0 PF10162; A4IF63 CHOYP_BRAFLDRAFT_99993.1.4 m.3253 sp TRIM2_BOVIN 23.776 143 105 3 121 260 602 743 1.42E-06 54.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_contig_017536 m.20561 sp TRIM2_BOVIN 23.469 196 128 4 183 357 549 743 1.42E-07 58.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NMZ7 CHOYP_CO6A4.1.1 m.4979 sp CO6A6_HUMAN 30.848 389 245 10 28 411 618 987 1.42E-46 188 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; B2RU80 CHOYP_PTPRB.1.4 m.21615 sp PTPRB_MOUSE 31.175 834 472 30 863 1654 1219 1992 1.42E-88 325 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; D3YXG0 CHOYP_BRAFLDRAFT_88354.2.3 m.13010 sp HMCN1_MOUSE 25 392 273 12 13 390 33 417 1.42E-22 107 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E9Q6J5 CHOYP_LOC100373080.5.6 m.36541 sp BD1L1_MOUSE 54.808 104 47 0 12 115 50 153 1.42E-33 145 BD1L1_MOUSE reviewed Biorientation of chromosomes in cell division protein 1-like 1 Bod1l Kiaa1327 Mus musculus (Mouse) 3032 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] GO:0003677; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0031297 0 0 0 0 E9Q6J5 CHOYP_LOC100373080.6.6 m.45784 sp BD1L1_MOUSE 54.808 104 47 0 12 115 50 153 1.42E-33 145 BD1L1_MOUSE reviewed Biorientation of chromosomes in cell division protein 1-like 1 Bod1l Kiaa1327 Mus musculus (Mouse) 3032 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] GO:0003677; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0031297 0 0 0 0 F1LMN3 CHOYP_E2F7.2.2 m.12838 sp E2F8_RAT 46.926 309 130 6 133 421 56 350 1.42E-75 268 E2F8_RAT reviewed Transcription factor E2F8 (E2F-8) E2f8 Rattus norvegicus (Rat) 860 "cell cycle comprising mitosis without cytokinesis [GO:0033301]; chorionic trophoblast cell differentiation [GO:0060718]; hepatocyte differentiation [GO:0070365]; negative regulation of cytokinesis [GO:0032466]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; sprouting angiogenesis [GO:0002040]; transcription, DNA-templated [GO:0006351]; trophoblast giant cell differentiation [GO:0060707]" GO:0000122; GO:0001890; GO:0002040; GO:0003677; GO:0003700; GO:0003714; GO:0005634; GO:0005667; GO:0006351; GO:0032466; GO:0032877; GO:0033301; GO:0060707; GO:0060718; GO:0070365 0 0 0 PF02319; O15120 CHOYP_AGAP_AGAP002021.1.1 m.42135 sp PLCB_HUMAN 41.86 215 119 4 62 273 54 265 1.42E-43 152 PLCB_HUMAN reviewed 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 2) (1-AGP acyltransferase 2) (1-AGPAT 2) (Lysophosphatidic acid acyltransferase beta) (LPAAT-beta) AGPAT2 Homo sapiens (Human) 278 CDP-diacylglycerol biosynthetic process [GO:0016024]; epidermis development [GO:0008544]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid metabolic process [GO:0006644]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of cytokine production [GO:0001819]; response to antidepressant [GO:0036276]; triglyceride biosynthetic process [GO:0019432] GO:0001819; GO:0001961; GO:0003841; GO:0005783; GO:0005789; GO:0006644; GO:0006654; GO:0008544; GO:0016021; GO:0016024; GO:0019432; GO:0036276 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. 0 0 PF01553; O15439 CHOYP_BRAFLDRAFT_278564.1.1 m.39745 sp MRP4_HUMAN 39.96 503 275 4 11 509 96 575 1.42E-122 392 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O17320 CHOYP_LOC100533357.1.2 m.56853 sp ACT_CRAGI 59.434 106 32 1 1 106 191 285 1.42E-31 117 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O46160 CHOYP_RL14.4.9 m.33280 sp RL14_LUMRU 64.583 144 50 1 10 152 1 144 1.42E-60 187 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O61231 CHOYP_RL10.2.3 m.13809 sp RL10_DROME 82.243 214 38 0 18 231 1 214 1.42E-131 372 RL10_DROME reviewed 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0043025; GO:0051297; GO:0051298 0 0 cd01433; PF00252; P10041 CHOYP_contig_033711 m.38311 sp DL_DROME 31.004 229 136 3 1 229 462 668 1.42E-26 112 DL_DROME reviewed Neurogenic locus protein delta Dl CG3619 Drosophila melanogaster (Fruit fly) 833 "actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; asymmetric cell division [GO:0008356]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye retinal cell programmed cell death [GO:0046667]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; ectoderm development [GO:0007398]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; germ-line stem cell population maintenance [GO:0030718]; glial cell migration [GO:0008347]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; R3/R4 cell fate commitment [GO:0007464]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of R8 cell spacing in compound eye [GO:0045468]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]; stem cell differentiation [GO:0048863]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]" GO:0001708; GO:0001736; GO:0005102; GO:0005112; GO:0005509; GO:0005768; GO:0005886; GO:0005912; GO:0007015; GO:0007155; GO:0007219; GO:0007298; GO:0007314; GO:0007398; GO:0007399; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007451; GO:0007460; GO:0007464; GO:0007474; GO:0007475; GO:0007476; GO:0007480; GO:0007498; GO:0008284; GO:0008347; GO:0008356; GO:0008407; GO:0008586; GO:0009986; GO:0016021; GO:0016318; GO:0016330; GO:0019233; GO:0030139; GO:0030431; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0031410; GO:0035003; GO:0035155; GO:0035157; GO:0036011; GO:0042067; GO:0042676; GO:0045465; GO:0045468; GO:0045931; GO:0046331; GO:0046667; GO:0048190; GO:0048477; GO:0048749; GO:0048800; GO:0048863; GO:0050768 0 0 0 PF01414;PF00008;PF12661;PF07657; P10394 CHOYP_LOC100708199.1.6 m.14240 sp POL4_DROME 28.109 989 629 20 237 1166 224 1189 1.42E-119 406 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P14842 CHOYP_BRAFLDRAFT_124668.1.1 m.51289 sp 5HT2A_RAT 22.955 379 236 12 21 364 73 430 1.42E-10 67.8 5HT2A_RAT reviewed 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) Htr2a Htr2 Rattus norvegicus (Rat) 471 "activation of phospholipase C activity [GO:0007202]; aging [GO:0007568]; artery smooth muscle contraction [GO:0014824]; behavioral response to cocaine [GO:0048148]; cell death [GO:0008219]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G-protein coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glycolytic process [GO:0045821]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; positive regulation of vasoconstriction [GO:0045907]; protein localization to cytoskeleton [GO:0044380]; regulation of behavior [GO:0050795]; regulation of dopamine secretion [GO:0014059]; regulation of hormone secretion [GO:0046883]; release of sequestered calcium ion into cytosol [GO:0051209]; response to drug [GO:0042493]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]; temperature homeostasis [GO:0001659]; urinary bladder smooth muscle contraction [GO:0014832]" GO:0001659; GO:0001965; GO:0004993; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005901; GO:0007186; GO:0007202; GO:0007204; GO:0007208; GO:0007568; GO:0007613; GO:0008144; GO:0008219; GO:0008284; GO:0010513; GO:0014059; GO:0014065; GO:0014824; GO:0014832; GO:0016020; GO:0016023; GO:0019233; GO:0030424; GO:0030425; GO:0030431; GO:0032403; GO:0042493; GO:0043025; GO:0043198; GO:0043267; GO:0043406; GO:0044380; GO:0045600; GO:0045821; GO:0045907; GO:0046883; GO:0048148; GO:0050731; GO:0050795; GO:0050965; GO:0050966; GO:0051209; GO:0051378; GO:0051967; GO:0070374; GO:0070852; GO:0071886 0 0 0 PF00001; P18433 CHOYP_LOC101076860.1.1 m.46820 sp PTPRA_HUMAN 34.343 396 239 9 21 406 122 506 1.42E-64 224 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P24008 CHOYP_LOC100888209.1.1 m.29529 sp S5A1_RAT 34.296 277 146 7 24 297 16 259 1.42E-40 144 S5A1_RAT reviewed 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1) Srd5a1 Rattus norvegicus (Rat) 259 "androgen biosynthetic process [GO:0006702]; androgen metabolic process [GO:0008209]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to organic cyclic compound [GO:0071407]; cellular response to starvation [GO:0009267]; cellular response to testosterone stimulus [GO:0071394]; cerebral cortex development [GO:0021987]; circadian sleep/wake cycle, REM sleep [GO:0042747]; diterpenoid metabolic process [GO:0016101]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; liver development [GO:0001889]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; male sex differentiation [GO:0046661]; pituitary gland development [GO:0021983]; progesterone metabolic process [GO:0042448]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to follicle-stimulating hormone [GO:0032354]; response to fungicide [GO:0060992]; response to growth hormone [GO:0060416]; response to muscle activity [GO:0014850]; response to organic cyclic compound [GO:0014070]; response to testosterone [GO:0033574]; serotonin metabolic process [GO:0042428]; spinal cord development [GO:0021510]; steroid biosynthetic process [GO:0006694]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]" GO:0001655; GO:0001889; GO:0003865; GO:0005737; GO:0005789; GO:0006694; GO:0006702; GO:0008209; GO:0008584; GO:0009267; GO:0014070; GO:0014850; GO:0016021; GO:0016101; GO:0021510; GO:0021766; GO:0021794; GO:0021854; GO:0021983; GO:0021987; GO:0030154; GO:0030539; GO:0030540; GO:0031090; GO:0032354; GO:0032355; GO:0032869; GO:0033218; GO:0033574; GO:0042428; GO:0042448; GO:0042493; GO:0042747; GO:0043025; GO:0043209; GO:0043231; GO:0043627; GO:0046661; GO:0047751; GO:0048471; GO:0060348; GO:0060416; GO:0060992; GO:0070402; GO:0070852; GO:0071320; GO:0071363; GO:0071392; GO:0071394; GO:0071407; GO:0071549; GO:0071872 0 0 0 PF02544; P24539 CHOYP_HS90A.3.3 m.28300 sp AT5F1_HUMAN 31.156 199 129 4 182 377 58 251 1.42E-22 99 AT5F1_HUMAN reviewed "ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)" ATP5F1 Homo sapiens (Human) 256 ATP biosynthetic process [GO:0006754]; ATP synthesis coupled proton transport [GO:0015986]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; substantia nigra development [GO:0021762] GO:0000276; GO:0005634; GO:0005654; GO:0005739; GO:0005743; GO:0005753; GO:0005759; GO:0006754; GO:0015078; GO:0015986; GO:0016020; GO:0021762; GO:0022857; GO:0042776; GO:0043209; GO:0070062 0 0 0 PF05405; P24733 CHOYP_MYS.1.7 m.437 sp MYS_ARGIR 70.202 198 59 0 1 198 1594 1791 1.42E-86 282 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P24792 CHOYP_LOC100376857.5.7 m.60759 sp ASO_CUCMA 27.961 608 304 23 101 667 53 567 1.42E-46 177 ASO_CUCMA reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Cucurbita maxima (Pumpkin) (Winter squash) 579 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P41413 CHOYP_LOC692448.1.1 m.58194 sp PCSK5_RAT 39.109 404 216 11 1 396 220 601 1.42E-77 266 PCSK5_RAT reviewed Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin/kexin-like protease PC5) (rPC5) Pcsk5 Rattus norvegicus (Rat) 1809 anterior/posterior pattern specification [GO:0009952]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; cytokine biosynthetic process [GO:0042089]; determination of left/right symmetry [GO:0007368]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058] GO:0001822; GO:0002001; GO:0003279; GO:0004252; GO:0005615; GO:0005794; GO:0006465; GO:0007368; GO:0007566; GO:0009952; GO:0016021; GO:0016485; GO:0016486; GO:0019058; GO:0030141; GO:0030323; GO:0035108; GO:0042089; GO:0042277; GO:0043043; GO:0048566; GO:0048706; GO:0060976 0 0 0 PF14843;PF01483;PF00082;PF16470; P48416 CHOYP_CYP301B1.2.2 m.33176 sp CP10_LYMST 30.181 497 299 17 61 536 75 544 1.42E-62 217 CP10_LYMST reviewed Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 545 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037 0 0 0 PF00067; P62184 CHOYP_RCOM_0910780.1.1 m.49228 sp CALM_RENRE 40.559 143 83 1 9 149 5 147 1.42E-37 128 CALM_RENRE reviewed Calmodulin (CaM) 0 Renilla reniformis (Sea pansy) 149 0 GO:0005509 0 0 0 PF13499; P90893 CHOYP_BRAFLDRAFT_284130.1.1 m.27065 sp YM9I_CAEEL 37.445 454 268 9 56 498 61 509 1.42E-94 300 YM9I_CAEEL reviewed Putative serine protease F56F10.1 (EC 3.4.-.-) F56F10.1 Caenorhabditis elegans 540 innate immune response [GO:0045087]; proteolysis [GO:0006508] GO:0004185; GO:0006508; GO:0008239; GO:0045087; GO:0045121 0 0 0 PF05577; P98164 CHOYP_LOC578656.7.15 m.41941 sp LRP2_HUMAN 30.816 331 218 7 1 325 690 1015 1.42E-38 154 LRP2_HUMAN reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) 4655 aorta development [GO:0035904]; cell proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; endocytosis [GO:0006897]; forebrain development [GO:0030900]; lipid metabolic process [GO:0006629]; protein glycosylation [GO:0006486]; receptor-mediated endocytosis [GO:0006898]; retinoid metabolic process [GO:0001523]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359] GO:0001523; GO:0003281; GO:0005041; GO:0005509; GO:0005764; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005905; GO:0006486; GO:0006629; GO:0006897; GO:0006898; GO:0008283; GO:0016021; GO:0016324; GO:0030139; GO:0030900; GO:0031526; GO:0035904; GO:0042359; GO:0042954; GO:0043235; GO:0060976; GO:0070062 0 0 0 PF12662;PF07645;PF00057;PF00058; Q04832 CHOYP_LOC100142137.1.1 m.52129 sp HEXP_LEIMA 36.538 104 54 3 72 170 33 129 1.42E-11 64.3 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q06852 CHOYP_contig_045589 m.53086 sp SLAP1_CLOTH 56.552 145 48 10 312 446 1601 1740 1.42E-08 61.2 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q17232 CHOYP_TYRR.1.1 m.14175 sp OAR_BOMMO 23.333 450 278 18 16 428 59 478 1.42E-10 66.6 OAR_BOMMO reviewed Octopamine receptor 0 Bombyx mori (Silk moth) 479 0 GO:0004989; GO:0005886; GO:0016021 0 0 0 PF00001; Q1PRL4 CHOYP_contig_031160 m.35549 sp LIN41_CHICK 23.182 220 124 6 10 196 205 412 1.42E-07 55.8 LIN41_CHICK reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) 876 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q4LDE5 CHOYP_LOC100367084.7.22 m.38583 sp SVEP1_HUMAN 24.265 680 415 27 250 863 434 1079 1.42E-27 124 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q502W6 CHOYP_BRAFLDRAFT_117157.2.3 m.26750 sp VWA3B_HUMAN 35.606 132 84 1 67 198 1033 1163 1.42E-17 91.7 VWA3B_HUMAN reviewed von Willebrand factor A domain-containing protein 3B VWA3B Homo sapiens (Human) 1294 0 0 0 0 0 PF15057;PF13768; Q505H4 CHOYP_LOC100691455.1.1 m.3282 sp VWC2L_MOUSE 39 100 56 3 54 149 116 214 1.42E-13 68.9 VWC2L_MOUSE reviewed von Willebrand factor C domain-containing protein 2-like (Brorin-like) Vwc2l Mus musculus (Mouse) 222 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of neuron differentiation [GO:0045666] GO:0005615; GO:0030054; GO:0030514; GO:0032281; GO:0045202; GO:0045666 0 0 0 0 Q5BIM1 CHOYP_TRI33.7.8 m.63558 sp TRI45_BOVIN 30.435 92 61 1 10 98 131 222 1.42E-07 52 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5DTY9 CHOYP_LOC100879129.1.1 m.44467 sp KCD16_MOUSE 46.183 262 130 6 7 262 22 278 1.42E-72 231 KCD16_MOUSE reviewed BTB/POZ domain-containing protein KCTD16 Kctd16 Gm1267 Kiaa1317 Mus musculus (Mouse) 427 protein homooligomerization [GO:0051260]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0008277; GO:0030054; GO:0042734; GO:0043235; GO:0045211; GO:0051260 0 0 0 PF02214; Q5R875 CHOYP_TMX3.1.2 m.22932 sp TMX3_PONAB 48.026 152 73 4 1 150 10 157 1.42E-41 147 TMX3_PONAB reviewed Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) TMX3 TXNDC10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 454 cell redox homeostasis [GO:0045454] GO:0003756; GO:0005789; GO:0016021; GO:0045454 0 0 0 PF00085; Q5SUF2 CHOYP_LC7L3.1.1 m.20705 sp LC7L3_MOUSE 52.571 350 142 5 28 370 5 337 1.42E-82 265 LC7L3_MOUSE reviewed Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) Luc7l3 Crop Mus musculus (Mouse) 432 mRNA splice site selection [GO:0006376]; RNA splicing [GO:0008380] GO:0003677; GO:0003729; GO:0005634; GO:0005654; GO:0005685; GO:0006376; GO:0008380; GO:0016607; GO:0044822; GO:0071004 0 0 0 PF03194; Q5ZID0 CHOYP_NMRL1.1.1 m.53558 sp NMRL1_CHICK 39.414 307 165 7 30 333 5 293 1.42E-67 217 NMRL1_CHICK reviewed NmrA-like family domain-containing protein 1 NMRAL1 RCJMB04_27o15 Gallus gallus (Chicken) 296 0 GO:0005634; GO:0048471 0 0 0 PF05368; Q62636 CHOYP_RAP1B.1.1 m.37175 sp RAP1B_RAT 79.259 135 25 2 1 134 52 184 1.42E-71 215 RAP1B_RAT reviewed Ras-related protein Rap-1b (GTP-binding protein smg p21B) Rap1b Rattus norvegicus (Rat) 184 cell proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to drug [GO:0035690]; cellular response to gonadotropin-releasing hormone [GO:0097211]; cellular response to organic cyclic compound [GO:0071407]; establishment of endothelial barrier [GO:0061028]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of establishment of cell polarity [GO:2000114]; response to carbohydrate [GO:0009743] GO:0003924; GO:0005525; GO:0005829; GO:0005886; GO:0005911; GO:0008283; GO:0009743; GO:0019003; GO:0032486; GO:0035690; GO:0061028; GO:0070374; GO:0071320; GO:0071407; GO:0097211; GO:1901888; GO:2000114; GO:2000301 0 0 0 PF00071; Q64487 CHOYP_LOC100635116.2.5 m.22323 sp PTPRD_MOUSE 30.309 551 346 11 498 1020 1337 1877 1.42E-66 249 PTPRD_MOUSE reviewed Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) Ptprd Mus musculus (Mouse) 1912 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of JAK-STAT cascade [GO:0046426]; neuron differentiation [GO:0030182]; positive regulation of dendrite morphogenesis [GO:0050775]; presynaptic membrane assembly [GO:0097105]; regulation of immune response [GO:0050776] GO:0004725; GO:0005102; GO:0007157; GO:0016021; GO:0030182; GO:0046426; GO:0050775; GO:0050776; GO:0050839; GO:0097105 0 0 0 PF00041;PF07679;PF00102; Q64605 CHOYP_DWIL_GK25195.1.1 m.60554 sp PTPRS_RAT 30.314 287 180 11 216 491 1327 1604 1.42E-23 108 PTPRS_RAT reviewed Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) Ptprs Rattus norvegicus (Rat) 1907 cell adhesion [GO:0007155] GO:0004725; GO:0007155; GO:0016021 0 0 0 PF00041;PF07679;PF00102; Q68D06 CHOYP_SLFN5.1.1 m.23987 sp SLN13_HUMAN 21.53 915 586 28 51 898 46 895 1.42E-54 208 SLN13_HUMAN reviewed Schlafen family member 13 SLFN13 Homo sapiens (Human) 897 0 GO:0005524; GO:0005622 0 0 0 PF04326;PF09848; Q6PA48 CHOYP_TBRG4.1.1 m.48213 sp TBRG4_XENLA 23.136 523 349 17 143 632 126 628 1.42E-18 93.2 TBRG4_XENLA reviewed Protein TBRG4 (Transforming growth factor beta regulator 4) tbrg4 Xenopus laevis (African clawed frog) 633 cellular respiration [GO:0045333] GO:0004672; GO:0005739; GO:0045333 0 0 0 PF06743;PF08368;PF08373; Q75JP5 CHOYP_contig_023481 m.26729 sp Y2471_DICDI 49.55 111 20 5 189 263 786 896 1.42E-07 57.4 Y2471_DICDI reviewed Calponin homology domain-containing protein DDB_G0272472 DDB_G0272472 Dictyostelium discoideum (Slime mold) 1508 0 0 0 0 0 PF00307; Q7TMA5 CHOYP_LOC100370756.1.1 m.43508 sp APOB_RAT 25.904 332 218 10 38 360 31 343 1.42E-20 97.4 APOB_RAT reviewed Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)] Apob Aa1064 Ac1-060 Rattus norvegicus (Rat) 4743 artery morphogenesis [GO:0048844]; cellular response to prostaglandin stimulus [GO:0071379]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle remodeling [GO:0034374]; nervous system development [GO:0007399]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of gene expression [GO:0010628]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; post-embryonic development [GO:0009791]; regulation of cholesterol biosynthetic process [GO:0045540]; response to carbohydrate [GO:0009743]; response to lipopolysaccharide [GO:0032496]; response to organic substance [GO:0010033]; response to selenium ion [GO:0010269]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; sperm motility [GO:0030317]; triglyceride catabolic process [GO:0019433]; triglyceride mobilization [GO:0006642] GO:0001701; GO:0005543; GO:0005615; GO:0005737; GO:0005783; GO:0005794; GO:0005886; GO:0006629; GO:0006642; GO:0007283; GO:0007399; GO:0008201; GO:0008203; GO:0008289; GO:0009566; GO:0009615; GO:0009743; GO:0009791; GO:0010033; GO:0010269; GO:0010628; GO:0010744; GO:0010886; GO:0012506; GO:0015629; GO:0017127; GO:0019433; GO:0030317; GO:0031983; GO:0032496; GO:0033344; GO:0034359; GO:0034361; GO:0034362; GO:0034363; GO:0034374; GO:0034383; GO:0042158; GO:0042159; GO:0042632; GO:0042953; GO:0043025; GO:0043231; GO:0045540; GO:0048844; GO:0070062; GO:0071356; GO:0071379 0 0 0 PF12491;PF00134;PF06448;PF09172;PF01347; Q7TMK9 CHOYP_HNRPR.2.2 m.49438 sp HNRPQ_MOUSE 49.088 603 228 14 22 549 24 622 1.42E-177 517 HNRPQ_MOUSE reviewed "Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) (pp68)" Syncrip Hnrpq Nsap1 Nsap1l Mus musculus (Mouse) 623 cellular response to interferon-gamma [GO:0071346]; circadian rhythm [GO:0007623]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA processing [GO:0006397]; negative regulation of mRNA modification [GO:0090367]; negative regulation of translation [GO:0017148]; osteoblast differentiation [GO:0001649]; positive regulation of translation [GO:0045727]; RNA splicing [GO:0008380] GO:0000166; GO:0001649; GO:0003730; GO:0005654; GO:0005737; GO:0005783; GO:0006397; GO:0007623; GO:0008143; GO:0008380; GO:0016020; GO:0017148; GO:0030529; GO:0043025; GO:0044822; GO:0045727; GO:0048027; GO:0070934; GO:0070937; GO:0071013; GO:0071204; GO:0071346; GO:0090367; GO:0097452; GO:1990635 0 0 0 PF00076; Q7TT28 CHOYP_REXO1.1.1 m.7742 sp REXO1_MOUSE 41.894 623 301 11 580 1153 600 1210 1.42E-150 486 REXO1_MOUSE reviewed RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1) Rexo1 Kiaa1138 Tceb3bp1 Mus musculus (Mouse) 1213 0 GO:0003676; GO:0004527; GO:0005634 0 0 0 PF15870; Q7Z0T3 CHOYP_TRIADDRAFT_38448.1.1 m.27929 sp TEMPT_APLCA 44.248 113 59 4 36 145 9 120 1.42E-19 82.4 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q86Z23 CHOYP_LOC571639.1.1 m.27965 sp C1QL4_HUMAN 29.787 141 89 4 132 269 100 233 1.42E-09 60.5 C1QL4_HUMAN reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8BFQ8 CHOYP_PDDC1.1.1 m.16484 sp PDDC1_MOUSE 55.779 199 87 1 19 217 23 220 1.42E-80 243 PDDC1_MOUSE reviewed Parkinson disease 7 domain-containing protein 1 Pddc1 Mus musculus (Mouse) 220 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] GO:0019172; GO:0019243; GO:0070062 0 0 0 0 Q8BYM5 CHOYP_CEL.1.3 m.10583 sp NLGN3_MOUSE 30.622 418 237 15 3 400 241 625 1.42E-51 187 NLGN3_MOUSE reviewed Neuroligin-3 (Gliotactin homolog) Nlgn3 Mus musculus (Mouse) 825 "adult behavior [GO:0030534]; axon extension [GO:0048675]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; modulation of synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; oligodendrocyte differentiation [GO:0048709]; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000969]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; receptor-mediated endocytosis [GO:0006898]; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of terminal button organization [GO:2000331]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse organization [GO:0050808]; visual learning [GO:0008542]; vocalization behavior [GO:0071625]" GO:0002087; GO:0004872; GO:0005887; GO:0006898; GO:0007158; GO:0007612; GO:0008542; GO:0009986; GO:0030054; GO:0030139; GO:0030425; GO:0030534; GO:0035176; GO:0042043; GO:0043025; GO:0045202; GO:0048675; GO:0048709; GO:0050804; GO:0050808; GO:0050839; GO:0051965; GO:0051966; GO:0051968; GO:0052689; GO:0060024; GO:0060076; GO:0060077; GO:0060079; GO:0060080; GO:0060291; GO:0060999; GO:0061001; GO:0061002; GO:0071625; GO:0090394; GO:0097104; GO:0097105; GO:0097110; GO:0097151; GO:0098794; GO:1900271; GO:1902474; GO:2000310; GO:2000311; GO:2000331; GO:2000463; GO:2000809; GO:2000969 0 0 0 PF00135; Q8CDU5 CHOYP_LOC578680.1.1 m.49370 sp EFHB_MOUSE 47.863 585 298 4 8 590 262 841 1.42E-180 535 EFHB_MOUSE reviewed EF-hand domain-containing family member B Efhb Mus musculus (Mouse) 853 0 GO:0005509 0 0 0 PF13499; Q8CFI2 CHOYP_UB2R2.1.1 m.18979 sp UB2R1_MOUSE 69.068 236 71 1 1 236 1 234 1.42E-115 336 UB2R1_MOUSE reviewed Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) Cdc34 Ubch3 Ube2r1 Mus musculus (Mouse) 235 cell cycle [GO:0007049]; cellular response to interferon-beta [GO:0035458]; negative regulation of cAMP-mediated signaling [GO:0043951]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] GO:0000209; GO:0004842; GO:0005524; GO:0005654; GO:0005737; GO:0006513; GO:0007049; GO:0016567; GO:0031625; GO:0035458; GO:0043161; GO:0043951; GO:0061630; GO:0061631; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q8I7P9 CHOYP_contig_034878 m.39574 sp POL5_DROME 37.736 159 94 1 74 227 85 243 1.42E-25 108 POL5_DROME reviewed Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1003 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003676; GO:0003964; GO:0004519; GO:0005634; GO:0006313; GO:0008233; GO:0015074 0 0 0 PF00665;PF00078; Q8IDX6 CHOYP_ENS.1.3 m.25925 sp RBP2A_PLAF7 42.748 131 57 4 646 763 2740 2865 1.42E-09 66.6 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8JHV9 CHOYP_BIRC2.12.13 m.57192 sp BIR7A_XENLA 30.556 252 151 5 621 849 148 398 1.42E-30 128 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8K0U4 CHOYP_LOC100488894.4.5 m.35420 sp HS12A_MOUSE 30.769 143 99 0 49 191 439 581 1.42E-20 92 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N695 CHOYP_BRAFLDRAFT_202614.1.1 m.8765 sp SC5A8_HUMAN 39.33 567 318 9 4 564 9 555 1.42E-138 421 SC5A8_HUMAN reviewed Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) 610 apoptotic process [GO:0006915]; ion transport [GO:0006811]; sodium ion transport [GO:0006814] GO:0005886; GO:0005887; GO:0006811; GO:0006814; GO:0006915; GO:0008028; GO:0015293; GO:0016324; GO:0022803; GO:0070062 0 0 0 PF00474; Q8N695 CHOYP_LOC100313639.1.3 m.13526 sp SC5A8_HUMAN 37.582 612 358 10 8 615 9 600 1.42E-140 426 SC5A8_HUMAN reviewed Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) 610 apoptotic process [GO:0006915]; ion transport [GO:0006811]; sodium ion transport [GO:0006814] GO:0005886; GO:0005887; GO:0006811; GO:0006814; GO:0006915; GO:0008028; GO:0015293; GO:0016324; GO:0022803; GO:0070062 0 0 0 PF00474; Q8N7Z5 CHOYP_WRI_006090.1.1 m.34650 sp ANR31_HUMAN 41.346 104 61 0 49 152 1148 1251 1.42E-14 82.4 ANR31_HUMAN reviewed Putative ankyrin repeat domain-containing protein 31 ANKRD31 Homo sapiens (Human) 1873 0 0 0 0 0 PF00023;PF12796; Q8ND61 CHOYP_BRAFLDRAFT_118221.2.2 m.34844 sp CC020_HUMAN 33.333 171 108 4 797 965 666 832 1.42E-24 114 CC020_HUMAN reviewed Uncharacterized protein C3orf20 C3orf20 Homo sapiens (Human) 904 0 GO:0005737; GO:0016021 0 0 0 PF14977; Q8VCE1 CHOYP_SAMH1.4.12 m.21841 sp DJC28_MOUSE 34.626 361 223 6 19 375 33 384 1.42E-68 224 DJC28_MOUSE reviewed DnaJ homolog subfamily C member 28 Dnajc28 ORF28 Mus musculus (Mouse) 385 "Golgi organization [GO:0007030]; Golgi vesicle prefusion complex stabilization [GO:0048213]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000301; GO:0006890; GO:0007030; GO:0017119; GO:0048213 0 0 cd06257; PF00226;PF09350; Q8WV37 CHOYP_LOC100892461.1.2 m.11516 sp ZN480_HUMAN 38.961 77 45 1 103 179 259 333 1.42E-12 68.6 ZN480_HUMAN reviewed Zinc finger protein 480 ZNF480 Homo sapiens (Human) 535 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003700; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q924T9 CHOYP_LOC100744888.1.1 m.12511 sp CLTR2_RAT 23.125 320 202 8 4 313 22 307 1.42E-12 70.9 CLTR2_RAT reviewed Cysteinyl leukotriene receptor 2 (CysLTR2) (RSBPT32) Cysltr2 Cyslt2 Rattus norvegicus (Rat) 309 neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell death [GO:0010942]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0001631; GO:0005887; GO:0007200; GO:0007218; GO:0008528; GO:0010942; GO:0045766; GO:0070374 0 0 0 PF00001; Q93113 CHOYP_GST1D.1.1 m.58828 sp GST1D_ANOGA 46.154 182 96 2 72 253 9 188 1.42E-52 173 GST1D_ANOGA reviewed "Glutathione S-transferase 1, isoform D (EC 2.5.1.18) (EC 4.5.1.1) (AgGst1-alpha) (Aggst1-1) (Aggst1-6) (Aggst2-1) (DDT-dehydrochlorinase) (GST class-theta)" GstD1 GST1a AGAP004164 Anopheles gambiae (African malaria mosquito) 209 0 GO:0004364; GO:0018833 0 0 0 PF00043;PF02798; Q96II8 CHOYP_ZGC_171915.1.1 m.23422 sp LRCH3_HUMAN 36.364 803 400 20 12 784 44 765 1.42E-120 384 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q99315 CHOYP_LOC100494531.1.1 m.47105 sp YG31B_YEAST 22.198 464 311 15 209 670 593 1008 1.42E-09 65.5 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q99715 CHOYP_COCA1.5.6 m.57757 sp COCA1_HUMAN 30.769 403 225 14 237 625 107 469 1.42E-29 130 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q9BYJ9 CHOYP_COX1.6.15 m.25748 sp YTHD1_HUMAN 43.986 557 223 20 19 510 11 543 1.42E-126 384 YTHD1_HUMAN reviewed YTH domain-containing family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) YTHDF1 C20orf21 Homo sapiens (Human) 559 positive regulation of translational initiation [GO:0045948] GO:0005737; GO:0043022; GO:0044822; GO:0045948; GO:1990247 0 0 0 PF04146; Q9EPH8 CHOYP_LOC100370010.4.5 m.25253 sp PABP1_RAT 92.683 123 9 0 6 128 1 123 1.42E-80 253 PABP1_RAT reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Rattus norvegicus (Rat) 636 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0003729; GO:0005681; GO:0006397; GO:0008143; GO:0008380; GO:0010494; GO:0030425; GO:0030529; GO:0031047; GO:0060213; GO:1900153; GO:1990124; GO:2000623 0 0 0 PF00658;PF00076; Q9ESN6 CHOYP_BRAFLDRAFT_87269.4.8 m.39022 sp TRIM2_MOUSE 26.636 214 122 9 62 262 516 707 1.42E-08 58.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JJX8 CHOYP_LOC591895.1.1 m.36295 sp ST32B_MOUSE 62.042 382 142 2 1 380 1 381 1.42E-173 495 ST32B_MOUSE reviewed Serine/threonine-protein kinase 32B (EC 2.7.11.1) Stk32b Stk32 Mus musculus (Mouse) 414 intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105] GO:0004674; GO:0005524; GO:0005622; GO:0018105; GO:0035556; GO:0046872 0 0 0 PF00069; Q9R064 CHOYP_BRAFLDRAFT_118294.2.2 m.15439 sp GORS2_RAT 48 450 165 10 3 421 2 413 1.42E-124 372 GORS2_RAT reviewed Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) Gorasp2 Rattus norvegicus (Rat) 454 Golgi organization [GO:0007030]; organelle organization [GO:0006996] GO:0005794; GO:0005797; GO:0006996; GO:0007030; GO:0032580 0 0 0 PF04495; Q9UKK3 CHOYP_LOC100373327.4.13 m.30071 sp PARP4_HUMAN 48.229 593 297 6 41 625 621 1211 1.42E-174 566 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9Y5B8 CHOYP_NDK7.1.1 m.64883 sp NDK7_HUMAN 59.459 370 149 1 42 410 5 374 1.42E-172 490 NDK7_HUMAN reviewed Nucleoside diphosphate kinase 7 (NDK 7) (NDP kinase 7) (EC 2.7.4.6) (nm23-H7) NME7 Homo sapiens (Human) 376 CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] GO:0004550; GO:0005524; GO:0005813; GO:0006183; GO:0006228; GO:0006241; GO:0046872 0 0 0 PF06565;PF00334; Q9Y6M4 CHOYP_contig_018561 m.21772 sp KC1G3_HUMAN 35.433 127 64 5 2 125 332 443 1.42E-09 58.2 KC1G3_HUMAN reviewed Casein kinase I isoform gamma-3 (CKI-gamma 3) (EC 2.7.11.1) CSNK1G3 Homo sapiens (Human) 447 cellular protein modification process [GO:0006464]; endocytosis [GO:0006897]; peptidyl-serine phosphorylation [GO:0018105]; regulation of cell shape [GO:0008360]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006464; GO:0006897; GO:0007165; GO:0008360; GO:0016055; GO:0018105 0 0 0 PF12605;PF00069; Q9Z2W1 CHOYP_BIG3.1.1 m.51448 sp STK25_MOUSE 78.618 304 63 2 9 310 13 316 1.42E-162 472 STK25_MOUSE reviewed Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) Stk25 Sok1 Mus musculus (Mouse) 426 establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542] GO:0000139; GO:0004702; GO:0005524; GO:0005737; GO:0006468; GO:0007163; GO:0032874; GO:0036481; GO:0042542; GO:0042803; GO:0046777; GO:0046872; GO:0050772; GO:0051645; GO:0051683; GO:0070062; GO:0090168 0 0 0 PF00069; Q9Z2W1 CHOYP_LOC100121999.4.4 m.63100 sp STK25_MOUSE 78.618 304 63 2 9 310 13 316 1.42E-162 472 STK25_MOUSE reviewed Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) Stk25 Sok1 Mus musculus (Mouse) 426 establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542] GO:0000139; GO:0004702; GO:0005524; GO:0005737; GO:0006468; GO:0007163; GO:0032874; GO:0036481; GO:0042542; GO:0042803; GO:0046777; GO:0046872; GO:0050772; GO:0051645; GO:0051683; GO:0070062; GO:0090168 0 0 0 PF00069; A2VDD2 CHOYP_TC1DB.1.1 m.22354 sp TC1DB_XENLA 55.429 175 72 3 5 173 2 176 1.43E-69 211 TC1DB_XENLA reviewed Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) 176 0 0 0 0 0 PF03645; A7T0W1 CHOYP_UXT.1.1 m.35932 sp UXT_NEMVE 50.36 139 69 0 6 144 11 149 1.43E-46 152 UXT_NEMVE reviewed Protein UXT homolog v1g140887 Nematostella vectensis (Starlet sea anemone) 159 protein folding [GO:0006457] GO:0001104; GO:0001106; GO:0005634; GO:0006457; GO:0016272 0 0 0 PF02996; A9JRX0 CHOYP_MSL1.2.2 m.55937 sp MSL1_DANRE 30.164 305 162 12 76 377 210 466 1.43E-24 108 MSL1_DANRE reviewed Male-specific lethal 1-like 1 (MSL1-like 1) (Male-specific lethal-1 homolog 1) (MSL-1) msl1l1 zgc:175094 Danio rerio (Zebrafish) (Brachydanio rerio) 489 histone H4-K16 acetylation [GO:0043984] GO:0003682; GO:0043984; GO:0072487 0 0 0 PF16801;PF15275; B0JZG0 CHOYP_LOC100696193.1.1 m.47445 sp S23A2_XENTR 32.897 611 384 7 51 655 39 629 1.43E-115 363 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; B2RPV6 CHOYP_LOC101165018.2.5 m.13574 sp MMRN1_MOUSE 35.659 129 71 5 292 416 1087 1207 1.43E-09 63.9 MMRN1_MOUSE reviewed Multimerin-1 Mmrn1 Mus musculus (Mouse) 1210 blood coagulation [GO:0007596] GO:0005509; GO:0005576; GO:0007596 0 0 0 PF00386;PF00008;PF07546; C8YR32 CHOYP_BRAFLDRAFT_67580.1.2 m.8630 sp LOXH1_MOUSE 27.15 1849 1158 61 13 1745 290 2065 1.43E-158 543 LOXH1_MOUSE reviewed Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) 2068 detection of mechanical stimulus [GO:0050982]; sensory perception of sound [GO:0007605] GO:0005262; GO:0007605; GO:0016020; GO:0032420; GO:0050982 0 0 0 PF01477; F5H4B4 CHOYP_BRAFLDRAFT_85206.1.1 m.49234 sp F227A_HUMAN 24.706 340 220 8 26 358 6 316 1.43E-23 108 F227A_HUMAN reviewed Protein FAM227A FAM227A Homo sapiens (Human) 570 0 0 0 0 0 PF14922; O43915 CHOYP_LOC100647889.1.1 m.21149 sp VEGFD_HUMAN 26.131 199 125 6 19 204 46 235 1.43E-07 55.8 VEGFD_HUMAN reviewed Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) FIGF VEGFD Homo sapiens (Human) 354 angiogenesis [GO:0001525]; cell proliferation [GO:0008283]; dopaminergic neuron differentiation [GO:0071542]; induction of positive chemotaxis [GO:0050930]; platelet degranulation [GO:0002576]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell chemotaxis [GO:0060754]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to hypoxia [GO:0001666]; response to interleukin-1 [GO:0070555]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001666; GO:0002576; GO:0005161; GO:0005172; GO:0005576; GO:0005615; GO:0008283; GO:0008284; GO:0016020; GO:0030947; GO:0031093; GO:0032755; GO:0042056; GO:0048010; GO:0050930; GO:0051781; GO:0060754; GO:0070555; GO:0071542 0 0 0 PF00341; O70511 CHOYP_LOC100374274.1.3 m.9723 sp ANK3_RAT 27.778 360 214 13 20 344 232 580 1.43E-21 104 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O75489 CHOYP_DSIM_GD13354.1.1 m.6235 sp NDUS3_HUMAN 55.426 258 101 3 15 269 14 260 1.43E-101 300 NDUS3_HUMAN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)" NDUFS3 Homo sapiens (Human) 264 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of cell growth [GO:0030308]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; reactive oxygen species metabolic process [GO:0072593]; substantia nigra development [GO:0021762]" GO:0003954; GO:0005634; GO:0005739; GO:0005747; GO:0005759; GO:0006120; GO:0008137; GO:0009055; GO:0021762; GO:0030308; GO:0031966; GO:0032981; GO:0043209; GO:0072593; GO:2001243 0 0 0 PF00329; O95164 CHOYP_UBL3.1.1 m.57182 sp UBL3_HUMAN 68.067 119 35 1 12 130 2 117 1.43E-54 169 UBL3_HUMAN reviewed Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) UBL3 PNSC1 Homo sapiens (Human) 117 0 GO:0005622; GO:0005886; GO:0070062 0 0 0 0 O96790 CHOYP_NCLIV_0270.1.1 m.28202 sp DPGN_DIPMA 35.89 326 132 12 35 284 25 349 1.43E-39 146 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P02552 CHOYP_BRAFLDRAFT_58035.1.2 m.38252 sp TBA1_CHICK 99.306 144 1 0 1 144 139 282 1.43E-103 305 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P08548 CHOYP_LOC100371228.4.4 m.64707 sp LIN1_NYCCO 24.118 170 122 4 5 167 718 887 1.43E-09 63.2 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P0A651 CHOYP_LOC100371268.1.2 m.2159 sp Y3154_MYCBO 20.918 392 270 14 378 739 71 452 1.43E-13 77.8 Y3154_MYCBO reviewed Putative diacyglycerol O-acyltransferase Mb3154c (EC 2.3.1.20) (Putative triacylglycerol synthase Mb3154c) Mb3154c Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 463 glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432] GO:0004144; GO:0006071; GO:0019432 PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. 0 0 PF06974;PF03007; P12755 CHOYP_SKI.1.1 m.56091 sp SKI_HUMAN 35.897 741 318 22 10 633 14 714 1.43E-116 368 SKI_HUMAN reviewed Ski oncogene (Proto-oncogene c-Ski) SKI Homo sapiens (Human) 728 "anterior/posterior axis specification [GO:0009948]; BMP signaling pathway [GO:0030509]; bone morphogenesis [GO:0060349]; camera-type eye development [GO:0043010]; camera-type eye morphogenesis [GO:0048593]; cell motility [GO:0048870]; cell proliferation [GO:0008283]; embryonic limb morphogenesis [GO:0030326]; face morphogenesis [GO:0060325]; lens morphogenesis in camera-type eye [GO:0002089]; myelination in peripheral nervous system [GO:0022011]; myotube differentiation [GO:0014902]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of Schwann cell proliferation [GO:0010626]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neural tube closure [GO:0001843]; nose morphogenesis [GO:0043585]; olfactory bulb development [GO:0021772]; palate development [GO:0060021]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein homotrimerization [GO:0070207]; regulation of apoptotic process [GO:0042981]; retina development in camera-type eye [GO:0060041]; skeletal muscle fiber development [GO:0048741]; SMAD protein signal transduction [GO:0060395]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000122; GO:0001843; GO:0002089; GO:0003714; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005813; GO:0006351; GO:0007179; GO:0008270; GO:0008283; GO:0008285; GO:0009948; GO:0010626; GO:0014902; GO:0016604; GO:0016605; GO:0017053; GO:0019901; GO:0019904; GO:0021772; GO:0022011; GO:0030177; GO:0030326; GO:0030509; GO:0030512; GO:0030514; GO:0031625; GO:0032926; GO:0035019; GO:0042981; GO:0043010; GO:0043234; GO:0043388; GO:0043585; GO:0045668; GO:0045944; GO:0046332; GO:0046811; GO:0048147; GO:0048593; GO:0048741; GO:0048870; GO:0060021; GO:0060041; GO:0060325; GO:0060349; GO:0060395; GO:0070207; GO:0070491 0 0 0 PF08782;PF02437; P17666 CHOYP_CY250.1.1 m.15456 sp CP2CE_RABIT 41.667 444 250 6 16 453 20 460 1.43E-112 344 CP2CE_RABIT reviewed Cytochrome P450 2C14 (EC 1.14.14.1) (CYPIIC14) (Cytochrome P450 PHP3) CYP2C14 Oryctolagus cuniculus (Rabbit) 490 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P23286 CHOYP_LOC100786354.1.1 m.51918 sp CALM_CANAX 36.641 131 73 3 12 137 17 142 1.43E-17 77 CALM_CANAX reviewed Calmodulin (CaM) CMD1 Candida albicans (Yeast) 149 0 GO:0005509 0 0 0 PF13499; P31674 CHOYP_ISCW_ISCW016148.4.6 m.62162 sp RS15_ORYSJ 77.273 154 32 2 1 151 1 154 1.43E-82 242 RS15_ORYSJ reviewed 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) 154 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00203; P35408 CHOYP_PTGER4.3.3 m.40558 sp PE2R4_HUMAN 47.525 101 51 2 11 110 10 109 1.43E-23 97.4 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P35556 CHOYP_LOC100877035.1.1 m.9439 sp FBN2_HUMAN 46.602 618 315 8 2 609 2007 2619 1.43E-168 536 FBN2_HUMAN reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] FBN2 Homo sapiens (Human) 2912 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cellular response to growth factor stimulus [GO:0090287]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0022617; GO:0030023; GO:0030198; GO:0030326; GO:0030501; GO:0031012; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346; GO:0090287 0 0 0 PF12662;PF07645;PF12661;PF00683; P42674 CHOYP_LOC593467.3.4 m.66809 sp BP10_PARLI 33.251 406 234 15 158 553 71 449 1.43E-53 195 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P48509 CHOYP_LOC100716404.1.1 m.6638 sp CD151_HUMAN 28.309 272 159 7 3 272 16 253 1.43E-22 96.7 CD151_HUMAN reviewed CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151) CD151 TSPAN24 Homo sapiens (Human) 253 cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; hemidesmosome assembly [GO:0031581]; T cell proliferation [GO:0042098] GO:0005178; GO:0005604; GO:0005829; GO:0005886; GO:0005887; GO:0005925; GO:0007155; GO:0007166; GO:0016020; GO:0016477; GO:0031581; GO:0042098 0 0 0 PF00335; P53352 CHOYP_BRAFLDRAFT_117292.1.1 m.19637 sp INCE_CHICK 36.421 475 216 19 738 1186 449 863 1.43E-43 175 INCE_CHICK reviewed Inner centromere protein INCENP Gallus gallus (Chicken) 877 chromosome segregation [GO:0007059]; cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067] GO:0000775; GO:0000777; GO:0000910; GO:0005634; GO:0005721; GO:0005737; GO:0005819; GO:0005874; GO:0007059; GO:0007067; GO:0030496; GO:0043234 0 0 0 PF03941;PF12178; P62278 CHOYP_BRAFLDRAFT_208436.4.32 m.22689 sp RS13_RAT 88.667 150 17 0 1 150 1 150 1.43E-98 283 RS13_RAT reviewed 40S ribosomal protein S13 Rps13 Rattus norvegicus (Rat) 151 translation [GO:0006412] GO:0003735; GO:0005730; GO:0006412; GO:0022627; GO:0070181; GO:1990932 0 0 cd00353; PF08069;PF00312; P85298 CHOYP_SMP_006970.1.1 m.42551 sp RHG08_HUMAN 62.162 74 28 0 89 162 9 82 1.43E-29 115 RHG08_HUMAN reviewed Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) ARHGAP8 Homo sapiens (Human) 464 positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005737; GO:0005829; GO:0007165; GO:0051056; GO:0070374 0 0 0 PF13716;PF00620; P86854 CHOYP_MRC1.1.4 m.5852 sp PLCL_MYTGA 28.972 107 68 2 29 135 50 148 1.43E-10 61.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q0P4V4 CHOYP_BRAFLDRAFT_126826.1.1 m.14796 sp KTU_XENTR 35.294 629 369 13 1 602 1 618 1.43E-106 352 KTU_XENTR reviewed "Protein kintoun (Dynein assembly factor 2, axonemal)" dnaaf2 ktu Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 785 0 GO:0005737 0 0 0 PF08190; Q13231 CHOYP_PCCB.1.2 m.3057 sp CHIT1_HUMAN 46.316 475 214 8 27 492 23 465 1.43E-141 422 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q13489 CHOYP_BIRC2.11.13 m.57162 sp BIRC3_HUMAN 38.824 85 42 2 128 212 529 603 1.43E-09 60.5 BIRC3_HUMAN reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 MIHC RNF49 Homo sapiens (Human) 604 cell surface receptor signaling pathway [GO:0007166]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; protein heterooligomerization [GO:0051291]; regulation of apoptotic process [GO:0042981]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; spermatogenesis [GO:0007283]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007166; GO:0007249; GO:0007283; GO:0008270; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0031398; GO:0033209; GO:0034121; GO:0035666; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043234; GO:0045088; GO:0045121; GO:0050727; GO:0051291; GO:0060544; GO:0060546; GO:0070424; GO:1990001; GO:2000116 0 0 0 PF00653;PF00619; Q17QR8 CHOYP_LOC100537368.1.2 m.7563 sp HARB1_BOVIN 48.571 70 33 1 1 67 235 304 1.43E-15 73.6 HARB1_BOVIN reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 Bos taurus (Bovine) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0005813; GO:0046872 0 0 0 PF13359; Q20930 CHOYP_ADAMTS6.2.3 m.44531 sp MIG17_CAEEL 30.317 221 139 7 48 259 227 441 1.43E-21 96.7 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q28DE6 CHOYP_LOC578100.1.3 m.9754 sp RSBNL_XENTR 60 365 139 2 424 788 286 643 1.43E-153 486 RSBNL_XENTR reviewed Round spermatid basic protein 1-like rsbn1l TEgg039d07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 782 0 GO:0005634 0 0 0 0 Q28FF3 CHOYP_MFSD7.1.1 m.2536 sp MFS7A_XENTR 42.918 466 238 8 66 521 33 480 1.43E-127 384 MFS7A_XENTR reviewed Major facilitator superfamily domain-containing protein 7-a mfsd7-A TEgg026p17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 482 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q2PFW9 CHOYP_ISCW_ISCW019027.2.2 m.66984 sp NOVA1_MACFA 61.111 234 84 1 12 238 19 252 1.43E-92 285 NOVA1_MACFA reviewed RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Ventral neuron-specific protein 1) NOVA1 QflA-17531 QtsA-14227 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 483 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003723; GO:0005634 0 0 0 PF00013; Q497B8 CHOYP_LOC100178700.1.1 m.37554 sp KDM8_RAT 25 220 151 6 48 256 186 402 1.43E-11 69.3 KDM8_RAT reviewed Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) Kdm8 Jmjd5 Rattus norvegicus (Rat) 414 "G2/M transition of mitotic cell cycle [GO:0000086]; histone H3-K36 demethylation [GO:0070544]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0003682; GO:0005634; GO:0006351; GO:0045893; GO:0046872; GO:0051864; GO:0070544 0 0 0 0 Q4KMD7 CHOYP_LOC100375897.2.2 m.57836 sp STPAP_DANRE 32.886 149 100 0 6 154 203 351 1.43E-22 95.9 STPAP_DANRE reviewed Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) tut1 rbm21 zgc:112254 Danio rerio (Zebrafish) (Brachydanio rerio) 797 mRNA polyadenylation [GO:0006378]; pre-mRNA cleavage required for polyadenylation [GO:0098789]; snRNA processing [GO:0016180] GO:0003723; GO:0003730; GO:0004652; GO:0005524; GO:0005730; GO:0006378; GO:0008270; GO:0016180; GO:0016607; GO:0050265; GO:0098789 0 0 0 PF03828;PF00076; Q4R8E0 CHOYP_EIF2AK1.1.1 m.61504 sp E2AK1_MACFA 39.474 266 131 7 422 671 360 611 1.43E-48 184 E2AK1_MACFA reviewed Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Hemin-sensitive initiation factor 2-alpha kinase) EIF2AK1 QtsA-12694 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 631 negative regulation of translation [GO:0017148] GO:0004674; GO:0005524; GO:0005737; GO:0017148 0 0 0 PF00069; Q504N0 CHOYP_CBPA1.1.1 m.14075 sp CBPA2_MOUSE 33.178 428 252 10 31 445 6 412 1.43E-73 239 CBPA2_MOUSE reviewed Carboxypeptidase A2 (EC 3.4.17.15) Cpa2 Mus musculus (Mouse) 417 0 GO:0004180; GO:0004181; GO:0005576; GO:0005615; GO:0008270 0 0 0 PF00246;PF02244; Q5XK85 CHOYP_LOC100691694.1.1 m.34918 sp K0556_XENLA 35.714 224 125 2 524 747 370 574 1.43E-33 143 K0556_XENLA reviewed Protein KIAA0556 homolog 0 Xenopus laevis (African clawed frog) 1414 0 GO:0005737; GO:0005856; GO:0042995 0 0 0 PF14652; Q5ZKW0 CHOYP_MTU1.2.2 m.53076 sp MTU1_CHICK 52.28 329 132 3 12 317 2 328 1.43E-115 343 MTU1_CHICK reviewed Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) TRMU MTU1 RCJMB04_8p20 Gallus gallus (Chicken) 424 mitochondrial tRNA thio-modification [GO:0070903]; tRNA wobble position uridine thiolation [GO:0002143] GO:0000049; GO:0002143; GO:0005524; GO:0005739; GO:0016783; GO:0070903 0 0 cd01998; 0 Q68EF4 CHOYP_GRM3.1.2 m.35743 sp GRM4_MOUSE 29.213 178 110 4 384 547 25 200 1.43E-12 74.3 GRM4_MOUSE reviewed Metabotropic glutamate receptor 4 (mGluR4) Grm4 Gprc1d Mglur4 Mus musculus (Mouse) 912 "activation of MAPK activity [GO:0000187]; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [GO:0007196]; chemical synaptic transmission [GO:0007268]; learning [GO:0007612]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0000187; GO:0001642; GO:0004930; GO:0005622; GO:0005887; GO:0007196; GO:0007268; GO:0007612; GO:0008066; GO:0031410; GO:0042734; GO:0043005; GO:0051966 0 0 0 PF00003;PF01094;PF07562; Q68EK2 CHOYP_CALRL.3.3 m.65197 sp CALRL_DANRE 33.504 391 221 12 114 483 50 422 1.43E-62 215 CALRL_DANRE reviewed Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) calcrla calcrl si:dkey-249o24.2 zgc:100872 Danio rerio (Zebrafish) (Brachydanio rerio) 470 angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; cell surface receptor signaling pathway [GO:0007166]; somitogenesis [GO:0001756] GO:0001525; GO:0001756; GO:0004948; GO:0005886; GO:0007166; GO:0016021; GO:0048844 0 0 0 PF00002;PF02793; Q6AYP4 CHOYP_LOC100375200.1.1 m.28622 sp ZC21C_RAT 46.207 145 72 3 466 605 379 522 1.43E-35 144 ZC21C_RAT reviewed Zinc finger C2HC domain-containing protein 1C Zc2hc1c Fam164c Rattus norvegicus (Rat) 525 0 GO:0046872 0 0 0 0 Q6B9X6 CHOYP_LOC100636677.1.1 m.13568 sp VWKA_DICDI 28.421 95 59 2 150 235 498 592 1.43E-06 54.3 VWKA_DICDI reviewed Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) 625 contractile vacuole discharge [GO:0070177]; contractile vacuole organization [GO:0033298]; hypotonic response [GO:0006971]; mitotic cytokinesis [GO:0000281]; myosin II filament organization [GO:0031038]; peptidyl-serine modification [GO:0018209]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; regulation of sorocarp development [GO:0031156]; sorocarp morphogenesis [GO:0031288] GO:0000281; GO:0000331; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006971; GO:0018107; GO:0018209; GO:0031038; GO:0031156; GO:0031164; GO:0031288; GO:0033298; GO:0048471; GO:0070177 0 0 0 PF02816; Q6DFV8 CHOYP_BRAFLDRAFT_215789.1.1 m.60402 sp VWDE_MOUSE 26.623 462 294 20 49 489 58 495 1.43E-13 77.4 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6P5L7 CHOYP_LOC100533384.4.5 m.44796 sp ARGLA_DANRE 61.765 102 39 0 1 102 146 247 1.43E-29 108 ARGLA_DANRE reviewed Arginine and glutamate-rich protein 1-A arglu1a si:ch211-149b20.2 zgc:55375 Danio rerio (Zebrafish) (Brachydanio rerio) 251 0 0 0 0 0 PF15346; Q6P7A9 CHOYP_LOC100765804.1.1 m.61103 sp LYAG_RAT 39.759 83 35 3 32 114 476 543 1.43E-10 62 LYAG_RAT reviewed Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Gaa Rattus norvegicus (Rat) 953 glycogen catabolic process [GO:0005980] GO:0004558; GO:0005764; GO:0005765; GO:0005980; GO:0030246; GO:0032450 0 0 cd00111; PF13802;PF01055;PF16863;PF00088; Q6PGZ3 CHOYP_MIPT3.1.1 m.45356 sp MIPT3_DANRE 48.387 310 131 8 543 825 319 626 1.43E-67 239 MIPT3_DANRE reviewed TRAF3-interacting protein 1 traf3ip1 zgc:63522 Danio rerio (Zebrafish) (Brachydanio rerio) 629 cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; pronephros development [GO:0048793]; regulation of microtubule cytoskeleton organization [GO:0070507] GO:0005737; GO:0005813; GO:0005929; GO:0030992; GO:0042073; GO:0042384; GO:0048793; GO:0070507 0 0 0 0 Q6RUT8 CHOYP_LOC100370844.2.2 m.58790 sp CC154_MOUSE 21.617 532 355 12 197 697 67 567 1.43E-14 81.6 CC154_MOUSE reviewed Coiled-coil domain-containing protein 154 (Golgin-160-like protein) Ccdc154 Gm317 Mus musculus (Mouse) 657 0 GO:0005769 0 0 0 PF15450; Q6XL69 CHOYP_GPRNNA10.1.1 m.19604 sp OPN4_RUTRU 23.022 278 186 8 21 275 68 340 1.43E-06 54.3 OPN4_RUTRU reviewed Melanopsin (Opsin-4) opn4 Rutilus rutilus (Roach) 500 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0004930; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; Q7M456 CHOYP_RNOY.3.3 m.58342 sp RNOY_CRAGI 100 212 0 0 22 233 1 212 1.43E-159 443 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q801G2 CHOYP_MPRA.1.1 m.7507 sp MPRAB_DANRE 32.609 276 176 5 8 275 36 309 1.43E-38 142 MPRAB_DANRE reviewed "Membrane progestin receptor alpha-B (mPR alpha) (Progestin and adipoQ receptor family member VII, b)" paqr7b mpra paqr7 Danio rerio (Zebrafish) (Brachydanio rerio) 354 activation of MAPK activity [GO:0000187]; multicellular organism development [GO:0007275]; negative regulation of adenylate cyclase activity [GO:0007194]; oocyte maturation [GO:0001556]; response to steroid hormone [GO:0048545]; signal transduction [GO:0007165] GO:0000187; GO:0001556; GO:0003707; GO:0005496; GO:0005886; GO:0007165; GO:0007194; GO:0007275; GO:0016021; GO:0048545 0 0 0 PF03006; Q874R4 CHOYP_DYAK_GE10695.4.4 m.60817 sp PFL3_SCHPO 40.87 230 87 13 47 244 505 717 1.43E-06 52.8 PFL3_SCHPO reviewed Putative cell agglutination protein pfl3 (Pombe flocculin 3) pfl3 SPBC947.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 973 cell adhesion [GO:0007155] GO:0005783; GO:0007155; GO:0010339 0 0 0 PF11763; Q8BVD7 CHOYP_C1QT2.1.1 m.837 sp C1QT7_MOUSE 33.636 110 62 3 37 138 165 271 1.43E-09 57.8 C1QT7_MOUSE reviewed Complement C1q tumor necrosis factor-related protein 7 C1qtnf7 Ctrp7 Mus musculus (Mouse) 289 protein homooligomerization [GO:0051260] GO:0005581; GO:0005615; GO:0051260 0 0 0 PF00386;PF01391; Q8C1R0 CHOYP_LOC100378333.1.1 m.47946 sp TSSK5_MOUSE 42.105 285 160 4 43 324 20 302 1.43E-65 226 TSSK5_MOUSE reviewed Testis-specific serine/threonine-protein kinase 5 (TSK-5) (TSSK-5) (Testis-specific kinase 5) (EC 2.7.11.1) Tssk5 Mus musculus (Mouse) 372 cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007275; GO:0007283; GO:0030154; GO:0035556 0 0 0 PF00069; Q8TBH0 CHOYP_NEMVEDRAFT_V1G245881.1.1 m.1367 sp ARRD2_HUMAN 30.201 149 87 7 13 153 21 160 1.43E-08 56.2 ARRD2_HUMAN reviewed Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) 407 signal transduction [GO:0007165] GO:0005886; GO:0007165; GO:0031410 0 0 0 PF02752;PF00339; Q8TCB0 CHOYP_LOC101164969.1.1 m.5313 sp IFI44_HUMAN 24.706 170 114 4 122 284 153 315 1.43E-08 59.7 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q8TEJ3 CHOYP_LOC100121771.1.1 m.6351 sp SH3R3_HUMAN 32.123 358 188 10 41 377 200 523 1.43E-42 162 SH3R3_HUMAN reviewed SH3 domain-containing RING finger protein 3 (Plenty of SH3s 2) (SH3 multiple domains protein 4) SH3RF3 POSH2 SH3MD4 Homo sapiens (Human) 882 0 GO:0008270 0 0 0 PF00018;PF14604; Q8WPI2 CHOYP_LOC100905729.2.3 m.30601 sp BOOH2_RHIMP 40.845 71 42 0 11 81 1 71 1.43E-14 68.9 BOOH2_RHIMP reviewed Boophilin-H2 H2 Rhipicephalus microplus (Cattle tick) (Boophilus microplus) 142 0 GO:0004867; GO:0005576 0 0 0 PF00014; Q90705 CHOYP_EEF2.2.2 m.54908 sp EF2_CHICK 87.008 254 33 0 1 254 494 747 1.43E-161 472 EF2_CHICK reviewed Elongation factor 2 (EF-2) EEF2 Gallus gallus (Chicken) 858 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; Q922C1 CHOYP_BRAFLDRAFT_126338.1.1 m.59058 sp CS044_MOUSE 28.409 352 169 15 940 1273 339 625 1.43E-22 107 CS044_MOUSE reviewed Uncharacterized protein C19orf44 homolog 0 Mus musculus (Mouse) 641 0 0 0 0 0 PF15391; Q92832 CHOYP_PHUM_PHUM614580.1.1 m.6246 sp NELL1_HUMAN 34.038 473 273 10 29 479 29 484 1.43E-86 286 NELL1_HUMAN reviewed Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1) NELL1 NRP1 Homo sapiens (Human) 810 cell differentiation [GO:0030154]; negative regulation of cyclin catabolic process [GO:2000599]; negative regulation of osteoblast proliferation [GO:0033689]; nervous system development [GO:0007399]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of gene expression [GO:0010468] GO:0005509; GO:0005576; GO:0005635; GO:0005737; GO:0007399; GO:0010468; GO:0030154; GO:0030501; GO:0033689; GO:0045669; GO:0048471; GO:2000599 0 0 0 PF12947;PF07645;PF00093; Q96B67 CHOYP_BRAFLDRAFT_118530.1.1 m.35065 sp ARRD3_HUMAN 40.385 416 212 8 1 397 3 401 1.43E-99 305 ARRD3_HUMAN reviewed Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP) ARRDC3 KIAA1376 Homo sapiens (Human) 414 fat pad development [GO:0060613]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of multicellular organismal metabolic process [GO:0044252]; positive regulation of adrenergic receptor signaling pathway [GO:0071879]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; skin development [GO:0043588]; temperature homeostasis [GO:0001659] GO:0001659; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0031651; GO:0031699; GO:0043588; GO:0044252; GO:0051443; GO:0060613; GO:0071879; GO:0090327 0 0 0 PF02752;PF00339; Q96BR5 CHOYP_SELR1.1.1 m.29517 sp COA7_HUMAN 34.091 220 130 4 14 224 6 219 1.43E-29 113 COA7_HUMAN reviewed Cytochrome c oxidase assembly factor 7 (Beta-lactamase hcp-like protein) (Respiratory chain assembly factor 1) (Sel1 repeat-containing protein 1) COA7 C1orf163 RESA1 SELRC1 Homo sapiens (Human) 231 0 GO:0005758 0 0 0 PF08238; Q96FN9 CHOYP_LOC581508.1.1 m.26966 sp DTD2_HUMAN 58.385 161 65 1 6 164 8 168 1.43E-64 198 DTD2_HUMAN reviewed Probable D-tyrosyl-tRNA(Tyr) deacylase 2 (EC 3.1.-.-) (D-tyrosyl-tRNA deacylase 2) DTD2 C14orf126 Homo sapiens (Human) 168 D-amino acid catabolic process [GO:0019478]; tRNA metabolic process [GO:0006399] GO:0002161; GO:0005737; GO:0006399; GO:0019478; GO:0051500 0 0 0 PF02580; Q99315 CHOYP_contig_040127 m.45429 sp YG31B_YEAST 29.071 743 477 14 436 1148 587 1309 1.43E-82 301 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9BT43 CHOYP_POLR3GL.1.1 m.37844 sp RPC7L_HUMAN 48.02 202 98 3 12 211 15 211 1.43E-43 149 RPC7L_HUMAN reviewed DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like) POLR3GL Homo sapiens (Human) 218 positive regulation of type I interferon production [GO:0032481]; regulation of transcription from RNA polymerase III promoter [GO:0006359]; transcription initiation from RNA polymerase III promoter [GO:0006384] GO:0000790; GO:0005654; GO:0005666; GO:0005829; GO:0006359; GO:0006384; GO:0032481 0 0 0 PF11705; Q9CQT9 CHOYP_LOC100698115.1.1 m.14358 sp CT024_MOUSE 52 125 56 1 8 128 5 129 1.43E-43 142 CT024_MOUSE reviewed Uncharacterized protein C20orf24 homolog 0 Mus musculus (Mouse) 129 0 GO:0005739 0 0 0 PF07019; Q9ERH8 CHOYP_LOC100369565.1.2 m.7712 sp S28A3_MOUSE 48.162 544 256 8 79 609 102 632 1.43E-161 483 S28A3_MOUSE reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3) Slc28a3 Cnt3 Mus musculus (Mouse) 703 purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; retina homeostasis [GO:0001895] GO:0001895; GO:0005887; GO:0015389; GO:0015390; GO:0015860; GO:0015864 0 0 0 PF07670;PF07662;PF01773; Q9FKK7 CHOYP_LOC100632370.1.1 m.25156 sp XYLA_ARATH 51.957 460 216 3 1 460 20 474 1.43E-173 498 XYLA_ARATH reviewed Xylose isomerase (EC 5.3.1.5) XYLA At5g57655 MUA2.25 Arabidopsis thaliana (Mouse-ear cress) 477 D-xylose metabolic process [GO:0042732]; pentose-phosphate shunt [GO:0006098] GO:0005737; GO:0005773; GO:0005774; GO:0005783; GO:0005794; GO:0006098; GO:0009045; GO:0016020; GO:0042732; GO:0046872 0 0 0 0 Q9U1M8 CHOYP_MYO22.2.2 m.24750 sp MYOI_DICDI 42.257 833 431 11 21 819 15 831 1.43E-180 614 MYOI_DICDI reviewed Myosin-I heavy chain (Class VII unconventional myosin) (DdMVII) (DdM7) myoI DDB_G0274455 Dictyostelium discoideum (Slime mold) 2357 actin filament-based movement [GO:0030048]; cell morphogenesis [GO:0000902]; cell-substrate adhesion [GO:0031589]; filopodium assembly [GO:0046847]; phagocytosis [GO:0006909]; spore germination [GO:0009847] GO:0000902; GO:0001891; GO:0003774; GO:0003779; GO:0005524; GO:0005829; GO:0006909; GO:0008017; GO:0009847; GO:0016020; GO:0016459; GO:0030048; GO:0030175; GO:0030898; GO:0031252; GO:0031589; GO:0043621; GO:0046847; GO:0051015 0 0 0 PF00373;PF00063;PF00784;PF07653; Q9ULJ7 CHOYP_LOC577576.1.1 m.51477 sp ANR50_HUMAN 36.774 155 82 4 266 417 694 835 1.43E-14 80.1 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9V6X7 CHOYP_OFUT1.1.1 m.41737 sp OFUT1_DROME 48.159 353 165 4 1 335 4 356 1.43E-117 348 OFUT1_DROME reviewed GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Neurotic protein) (Peptide-O-fucosyltransferase 1) (O-FucT-1) O-fut1 nti CG12366 Drosophila melanogaster (Fruit fly) 402 "embryo development [GO:0009790]; endocytosis [GO:0006897]; fucose metabolic process [GO:0006004]; lateral inhibition [GO:0046331]; negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219]; O-glycan processing [GO:0016266]; positive regulation of Notch signaling pathway [GO:0045747]; protein catabolic process [GO:0030163]; protein O-linked glycosylation [GO:0006493]; regulation of Notch signaling pathway [GO:0008593]; regulation of transcription, DNA-templated [GO:0006355]; single organismal cell-cell adhesion [GO:0016337]" GO:0005112; GO:0005737; GO:0005783; GO:0006004; GO:0006355; GO:0006493; GO:0006897; GO:0007219; GO:0008417; GO:0008593; GO:0009790; GO:0016266; GO:0016337; GO:0030163; GO:0031410; GO:0045746; GO:0045747; GO:0046331; GO:0046922 PATHWAY: Protein modification; protein glycosylation. 0 0 PF10250; Q9Y2U8 CHOYP_LEMD3.1.1 m.56975 sp MAN1_HUMAN 35.635 449 247 13 269 689 470 904 1.43E-74 261 MAN1_HUMAN reviewed Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) LEMD3 MAN1 Homo sapiens (Human) 911 negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] GO:0000166; GO:0003677; GO:0005637; GO:0005639; GO:0016020; GO:0016021; GO:0030512; GO:0030514; GO:0032926 0 0 0 PF03020;PF09402; Q9Z0R0 CHOYP_LOC579644.1.1 m.16828 sp HASP_MOUSE 46.647 343 175 3 438 774 413 753 1.43E-98 325 HASP_MOUSE reviewed Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (Haploid germ cell-specific nuclear protein kinase) Gsg2 Mus musculus (Mouse) 754 "histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore [GO:2000751]; intracellular signal transduction [GO:0035556]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; protein localization to chromosome, centromeric region [GO:0071459]; protein phosphorylation [GO:0006468]; regulation of spindle checkpoint [GO:0090231]" GO:0003677; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0005813; GO:0005819; GO:0006468; GO:0007064; GO:0035556; GO:0071459; GO:0072354; GO:0090231; GO:2000134; GO:2000751 0 0 0 PF12330; Q9Z136 CHOYP_TSC1.1.1 m.5136 sp TSC1_RAT 39.295 369 196 4 13 359 5 367 1.43E-75 276 TSC1_RAT reviewed Hamartin (Tuberous sclerosis 1 protein homolog) Tsc1 Rattus norvegicus (Rat) 1163 activation of GTPase activity [GO:0090630]; adaptive immune response [GO:0002250]; adult locomotory behavior [GO:0008344]; cardiac muscle cell differentiation [GO:0055007]; cell-matrix adhesion [GO:0007160]; cell projection organization [GO:0030030]; cellular response to oxygen-glucose deprivation [GO:0090650]; cerebral cortex development [GO:0021987]; glucose import [GO:0046323]; hippocampus development [GO:0021766]; kidney development [GO:0001822]; memory T cell differentiation [GO:0043379]; myelination [GO:0042552]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of macroautophagy [GO:0016242]; negative regulation of TOR signaling [GO:0032007]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; positive regulation of focal adhesion assembly [GO:0051894]; potassium ion transport [GO:0006813]; protein heterooligomerization [GO:0051291]; protein stabilization [GO:0050821]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell cycle [GO:0051726]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of neuron death [GO:1901214]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of protein kinase activity [GO:0045859]; regulation of stress fiber assembly [GO:0051492]; response to insulin [GO:0032868]; rRNA export from nucleus [GO:0006407]; synapse organization [GO:0050808] GO:0001822; GO:0001843; GO:0002250; GO:0005634; GO:0005829; GO:0005856; GO:0005884; GO:0005886; GO:0005938; GO:0006407; GO:0006813; GO:0007160; GO:0008285; GO:0008344; GO:0016242; GO:0017148; GO:0021766; GO:0021987; GO:0030027; GO:0030030; GO:0030426; GO:0030695; GO:0032007; GO:0032794; GO:0032868; GO:0032956; GO:0033596; GO:0042552; GO:0043087; GO:0043231; GO:0043234; GO:0043379; GO:0043666; GO:0045792; GO:0045859; GO:0046323; GO:0046627; GO:0047485; GO:0048471; GO:0050808; GO:0050821; GO:0051291; GO:0051492; GO:0051726; GO:0051893; GO:0051894; GO:0055007; GO:0090630; GO:0090650; GO:1901214 0 0 0 PF04388; A0JMZ1 CHOYP_NSAPB.2.2 m.19172 sp NSAPB_XENLA 35.385 195 86 7 22 179 304 495 1.44E-15 76.6 NSAPB_XENLA reviewed Nucleolar and spindle-associated protein 1-B (NuSAP B) nusap1-b Xenopus laevis (African clawed frog) 496 establishment of mitotic spindle localization [GO:0040001]; meiotic cell cycle [GO:0051321]; mitotic cytokinesis [GO:0000281]; mitotic nuclear division [GO:0007067] GO:0000281; GO:0003677; GO:0005634; GO:0005737; GO:0005819; GO:0005874; GO:0007067; GO:0040001; GO:0051321 0 0 0 PF16006; A7YY35 CHOYP_IFRX2.1.10 m.3718 sp K2012_BOVIN 36.22 254 156 3 1075 1323 891 1143 1.44E-24 115 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; B3EWY9 CHOYP_BRAFLDRAFT_129967.1.4 m.4020 sp MLP_ACRMI 28.7 1115 633 42 304 1357 354 1367 1.44E-104 375 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; G5E8K5 CHOYP_LOC100376500.1.1 m.36605 sp ANK3_MOUSE 31.864 794 488 17 99 889 55 798 1.44E-93 340 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O08605 CHOYP_TALDO.2.2 m.43333 sp MKNK1_MOUSE 59.398 133 54 0 40 172 35 167 1.44E-49 168 MKNK1_MOUSE reviewed MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) Mknk1 Mnk1 Mus musculus (Mouse) 427 extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of translation [GO:0006417]; response to salt stress [GO:0009651] GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006417; GO:0006468; GO:0009651; GO:0009931; GO:0018105; GO:0035556; GO:0046777; GO:0097192 0 0 0 PF00069; O14522 CHOYP_MEG10.81.91 m.60828 sp PTPRT_HUMAN 39.891 183 107 2 496 677 855 1035 1.44E-32 139 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O18783 CHOYP_BRAFLDRAFT_90679.1.1 m.33411 sp PLMN_MACEU 38.462 481 202 19 717 1136 108 555 1.44E-83 293 PLMN_MACEU reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macropus eugenii (Tammar wallaby) 806 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; O55092 CHOYP_ISCW_ISCW014720.1.2 m.2306 sp SLK_CAVPO 44.503 382 212 0 283 664 819 1200 1.44E-85 296 SLK_CAVPO reviewed STE20-like serine/threonine-protein kinase (STE20-like kinase) (EC 2.7.11.1) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) SLK Cavia porcellus (Guinea pig) 1231 apoptotic process [GO:0006915]; protein autophosphorylation [GO:0046777]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893] GO:0004674; GO:0005524; GO:0005737; GO:0006915; GO:0030334; GO:0031252; GO:0042803; GO:0046777; GO:0048471; GO:0051893 0 0 0 PF00069;PF12474; O70277 CHOYP_BRAFLDRAFT_69764.9.19 m.32768 sp TRIM3_RAT 23.392 342 212 14 250 562 401 721 1.44E-07 58.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_TRIM2.9.59 m.20303 sp TRIM3_RAT 25.301 166 113 6 20 177 541 703 1.44E-07 55.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75096 CHOYP_LOC101243071.2.2 m.38901 sp LRP4_HUMAN 25.517 870 568 34 68 911 482 1297 1.44E-58 227 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; O88271 CHOYP_LOC100376688.1.8 m.12068 sp CFDP1_MOUSE 65.556 90 30 1 12 100 201 290 1.44E-32 117 CFDP1_MOUSE reviewed Craniofacial development protein 1 (27 kDa craniofacial protein) (Bucentaur) (Protein Cp27) Cfdp1 Bcnt Cfdp Cp27 Mus musculus (Mouse) 295 cell adhesion [GO:0007155]; multicellular organism development [GO:0007275]; negative regulation of fibroblast apoptotic process [GO:2000270]; regulation of cell proliferation [GO:0042127]; regulation of cell shape [GO:0008360] GO:0000777; GO:0005604; GO:0007155; GO:0007275; GO:0008360; GO:0042127; GO:2000270 0 0 0 PF07572; P01130 CHOYP_LDLR.2.7 m.15357 sp LDLR_HUMAN 59.091 66 26 1 79 143 80 145 1.44E-18 84.3 LDLR_HUMAN reviewed Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899] GO:0001618; GO:0001948; GO:0002020; GO:0004872; GO:0005041; GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005887; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0008203; GO:0009897; GO:0009986; GO:0010008; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0030669; GO:0032050; GO:0034362; GO:0034383; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0070508; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P08953 CHOYP_TOLL.2.2 m.35788 sp TOLL_DROME 39.267 191 104 6 249 436 838 1019 1.44E-26 117 TOLL_DROME reviewed Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) 1097 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cell adhesion [GO:0007155]; defense response [GO:0006952]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; dorsal/ventral axis specification [GO:0009950]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; mitotic cytokinesis [GO:0000281]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; regulation of hemocyte differentiation [GO:0045610]; regulation of melanization defense response [GO:0035007]; response to bacterium [GO:0009617]; response to fungus [GO:0009620]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]; zygotic specification of dorsal/ventral axis [GO:0007352] GO:0000281; GO:0002229; GO:0004888; GO:0005737; GO:0005769; GO:0005886; GO:0006952; GO:0006955; GO:0006963; GO:0006967; GO:0007155; GO:0007352; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009617; GO:0009620; GO:0009880; GO:0009897; GO:0009950; GO:0009986; GO:0016021; GO:0016201; GO:0019730; GO:0019732; GO:0019955; GO:0030097; GO:0032154; GO:0035007; GO:0035172; GO:0042802; GO:0043234; GO:0045087; GO:0045610; GO:0045944; GO:0050830; GO:0050832; GO:0070976; GO:1902875 0 0 0 PF00560;PF13306;PF13855;PF01462;PF01582; P0C6B8 CHOYP_LOC100367084.6.22 m.31843 sp SVEP1_RAT 23.948 689 413 22 111 707 436 1105 1.44E-30 135 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P13595 CHOYP_DPSE_GA13190.1.1 m.322 sp NCAM1_MOUSE 22.917 192 129 4 60 251 220 392 1.44E-08 59.7 NCAM1_MOUSE reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) Ncam1 Ncam Mus musculus (Mouse) 1115 axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; homotypic cell-cell adhesion [GO:0034109]; neuron projection development [GO:0031175]; positive regulation of calcium-mediated signaling [GO:0050850]; regulation of exocyst assembly [GO:0001928]; regulation of synaptic plasticity [GO:0048167] GO:0001928; GO:0005737; GO:0005886; GO:0005911; GO:0007166; GO:0007411; GO:0008201; GO:0009897; GO:0009986; GO:0016020; GO:0016021; GO:0030424; GO:0030426; GO:0031175; GO:0031225; GO:0034109; GO:0043025; GO:0043209; GO:0048167; GO:0050850; GO:0070062 0 0 0 PF00041;PF07679; P14543 CHOYP_LOC661043.1.1 m.11553 sp NID1_HUMAN 34.576 590 319 19 712 1257 679 1245 1.44E-80 293 NID1_HUMAN reviewed Nidogen-1 (NID-1) (Entactin) NID1 NID Homo sapiens (Human) 1247 basement membrane organization [GO:0071711]; cell-matrix adhesion [GO:0007160]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glomerular basement membrane development [GO:0032836]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0005509; GO:0005518; GO:0005576; GO:0005604; GO:0005605; GO:0007160; GO:0010811; GO:0022617; GO:0030198; GO:0031012; GO:0032836; GO:0043236; GO:0043394; GO:0070062; GO:0071711; GO:0071944 0 0 0 PF12662;PF12947;PF07645;PF07474;PF00058;PF06119;PF00086; P19217 CHOYP_LOC100459096.2.3 m.18153 sp ST1E1_BOVIN 35.069 288 160 9 25 299 19 292 1.44E-46 161 ST1E1_BOVIN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) 295 estrogen metabolic process [GO:0008210] GO:0004304; GO:0005496; GO:0005737; GO:0008210; GO:0050294 0 0 0 PF00685; P23206 CHOYP_C1QL3.2.5 m.52589 sp COAA1_BOVIN 29.221 154 93 5 26 178 534 672 1.44E-07 53.5 COAA1_BOVIN reviewed Collagen alpha-1(X) chain COL10A1 Bos taurus (Bovine) 674 0 GO:0005576; GO:0005578; GO:0005581 0 0 0 PF00386;PF01391; P36241 CHOYP_contig_011865 m.13636 sp RL19_DROME 79.688 128 26 0 12 139 32 159 1.44E-68 209 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P54145 CHOYP_AMT1.1.1 m.52961 sp AMT1_CAEEL 33.661 407 248 7 3 388 28 433 1.44E-60 209 AMT1_CAEEL reviewed Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans 534 ammonium transmembrane transport [GO:0072488]; nitrogen utilization [GO:0019740]; organic cation transport [GO:0015695] GO:0005887; GO:0008519; GO:0015695; GO:0019740; GO:0072488 0 0 0 PF00909; P58557 CHOYP_METTL6.1.1 m.16057 sp YBEY_HUMAN 43.75 160 89 1 1 160 1 159 1.44E-48 157 YBEY_HUMAN reviewed Putative ribonuclease YBEY C21orf57 Homo sapiens (Human) 167 rRNA processing [GO:0006364] GO:0004222; GO:0005634; GO:0005654; GO:0005739; GO:0006364; GO:0046872 0 0 0 PF02130; P70490 CHOYP_BRAFLDRAFT_118602.5.5 m.30806 sp MFGM_RAT 31.79 324 179 13 981 1285 111 411 1.44E-35 144 MFGM_RAT reviewed Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (O-acetyl GD3 ganglioside synthase) (AGS) (SED1) Mfge8 Ags Rattus norvegicus (Rat) 427 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of cell proliferation [GO:0008284]; response to estrogen [GO:0043627]; single fertilization [GO:0007338] GO:0001525; GO:0005576; GO:0007155; GO:0007338; GO:0008284; GO:0016020; GO:0043627 0 0 0 PF00008;PF00754; P90994 CHOYP_BRAFLDRAFT_94906.1.1 m.59345 sp DJ11_CAEEL 60.773 181 69 2 33 213 9 187 1.44E-70 216 DJ11_CAEEL reviewed Glutathione-independent glyoxalase DJR-1.1 (EC 4.2.1.130) (Protein DJ-1 homolog 1) djr-1.1 B0432.2 Caenorhabditis elegans 187 cellular response to glyoxal [GO:0036471]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to methylglyoxal [GO:0097238]; glycolate biosynthetic process [GO:0046295]; glyoxal catabolic process [GO:1903190]; methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; negative regulation of neuron death [GO:1901215]; protein deglycosylation [GO:0006517]; protein repair [GO:0030091]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to toxic substance [GO:0009636] GO:0003713; GO:0005634; GO:0005737; GO:0005829; GO:0006357; GO:0006517; GO:0009636; GO:0019172; GO:0019243; GO:0030091; GO:0036471; GO:0046295; GO:0070301; GO:0097238; GO:1901215; GO:1903190; GO:1990422 0 0 0 PF01965; Q09225 CHOYP_BRAFLDRAFT_66621.1.4 m.2674 sp NRF6_CAEEL 32.491 277 169 7 1 264 475 746 1.44E-37 144 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q09225 CHOYP_LOC100368914.1.3 m.26499 sp NRF6_CAEEL 33.547 468 253 16 481 912 355 800 1.44E-67 244 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q0KHY3 CHOYP_LOC574757.8.9 m.58740 sp MESH_DROME 26.015 961 610 35 144 1031 297 1229 1.44E-73 270 MESH_DROME reviewed Protein mesh mesh CG31004 Drosophila melanogaster (Fruit fly) 1454 cell-matrix adhesion [GO:0007160]; multicellular organism development [GO:0007275]; smooth septate junction assembly [GO:0090528] GO:0005920; GO:0007160; GO:0007275; GO:0016021; GO:0016327; GO:0090528 0 0 0 PF03782;PF06119;PF00084;PF00094; Q0VC92 CHOYP_LOC100397294.1.1 m.19498 sp MGN2_BOVIN 91.176 102 9 0 14 115 32 133 1.44E-63 193 MGN2_BOVIN reviewed Protein mago nashi homolog 2 MAGOHB MAGOH2 Bos taurus (Bovine) 148 "mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; RNA splicing [GO:0008380]" GO:0000184; GO:0006397; GO:0008380; GO:0035145; GO:0044822; GO:0051028; GO:0071013 0 0 cd11295; PF02792; Q13884 CHOYP_LOC592864.1.1 m.40116 sp SNTB1_HUMAN 48.295 528 216 13 13 494 22 538 1.44E-163 476 SNTB1_HUMAN reviewed Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43) SNTB1 SNT2B1 Homo sapiens (Human) 538 muscle contraction [GO:0006936] GO:0005198; GO:0005737; GO:0005856; GO:0005925; GO:0006936; GO:0016010; GO:0042383; GO:0043234; GO:0045202 0 0 0 PF00595;PF00169; Q16827 CHOYP_LOC663785.2.3 m.45348 sp PTPRO_HUMAN 39.896 193 101 5 1 191 1035 1214 1.44E-40 150 PTPRO_HUMAN reviewed Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2) PTPRO GLEPP1 PTPU2 Homo sapiens (Human) 1216 axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; glomerular visceral epithelial cell differentiation [GO:0072112]; glomerulus development [GO:0032835]; lamellipodium assembly [GO:0030032]; monocyte chemotaxis [GO:0002548]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron projection development [GO:0010977]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of glomerular filtration [GO:0003093]; slit diaphragm assembly [GO:0036060] GO:0000902; GO:0002548; GO:0003093; GO:0003105; GO:0004725; GO:0005001; GO:0005886; GO:0005887; GO:0006470; GO:0007411; GO:0010812; GO:0010977; GO:0016021; GO:0016324; GO:0016328; GO:0016791; GO:0017147; GO:0030027; GO:0030032; GO:0030424; GO:0030426; GO:0032835; GO:0035335; GO:0036060; GO:0042803; GO:0043005; GO:0043197; GO:0070062; GO:0072112; GO:0090090; GO:0090260 0 0 0 PF00041;PF00102; Q23157 CHOYP_TSP_10030.2.3 m.41891 sp INX11_CAEEL 26.786 392 243 9 7 363 20 402 1.44E-37 145 INX11_CAEEL reviewed Innexin-11 (Protein opu-11) inx-11 opu-11 W04D2.3 Caenorhabditis elegans 465 ion transport [GO:0006811] GO:0005243; GO:0005886; GO:0005921; GO:0006811; GO:0016021; GO:0055077; GO:1903763 0 0 0 PF00876; Q24524 CHOYP_ACOD.5.8 m.37926 sp SING_DROME 39.615 260 152 5 1 257 255 512 1.44E-60 202 SING_DROME reviewed Protein singed sn CG1536 Drosophila melanogaster (Fruit fly) 512 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; cuticle pattern formation [GO:0035017]; dendrite development [GO:0016358]; epidermal cell differentiation [GO:0009913]; establishment or maintenance of cell polarity [GO:0007163]; filopodium assembly [GO:0046847]; hemocyte migration [GO:0035099]; imaginal disc-derived wing hair organization [GO:0035317]; microvillar actin bundle assembly [GO:0030034]; neuron projection morphogenesis [GO:0048812]; oogenesis [GO:0048477]; wound healing [GO:0042060] GO:0003779; GO:0005737; GO:0007015; GO:0007163; GO:0008407; GO:0009913; GO:0015629; GO:0016358; GO:0030034; GO:0030036; GO:0035017; GO:0035099; GO:0035317; GO:0042060; GO:0043005; GO:0043025; GO:0046847; GO:0048477; GO:0048800; GO:0048812; GO:0051015; GO:0051017 0 0 0 PF06268; Q24K15 CHOYP_LOC100639584.2.3 m.22453 sp ANGP4_BOVIN 39.669 242 136 6 70 308 261 495 1.44E-57 196 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q29042 CHOYP_BRAFLDRAFT_108089.1.1 m.48191 sp FCN1_PIG 47.005 217 105 4 8 223 117 324 1.44E-51 173 FCN1_PIG reviewed Ficolin-1 (Ficolin-A) (Ficolin-alpha) FCN1 Sus scrofa (Pig) 326 innate immune response [GO:0045087] GO:0005576; GO:0005581; GO:0005886; GO:0030246; GO:0045087; GO:0046872 0 0 0 PF01391;PF00147; Q2KIY7 CHOYP_LOC100205688.1.1 m.20912 sp BT3L4_BOVIN 71.338 157 42 1 1 154 1 157 1.44E-68 210 BT3L4_BOVIN reviewed Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) BTF3L4 Bos taurus (Bovine) 158 0 0 0 0 0 PF01849; Q3V0Q6 CHOYP_BRAFLDRAFT_264461.1.1 m.51481 sp SPAG8_MOUSE 38.095 189 106 3 36 220 263 444 1.44E-30 120 SPAG8_MOUSE reviewed Sperm-associated antigen 8 (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84) Spag8 Mus musculus (Mouse) 470 cell cycle [GO:0007049]; cell differentiation [GO:0030154]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283] GO:0001669; GO:0005634; GO:0005737; GO:0005819; GO:0007049; GO:0007283; GO:0007338; GO:0030154; GO:0032092; GO:0045944 0 0 0 0 Q575S8 CHOYP_PHUM_PHUM323880.1.4 m.11051 sp CYGB2_DANRE 25.694 144 105 2 27 168 19 162 1.44E-13 68.6 CYGB2_DANRE reviewed Cytoglobin-2 cygb2 cygb-2 Danio rerio (Zebrafish) (Brachydanio rerio) 179 0 GO:0005344; GO:0005506; GO:0005737; GO:0019825; GO:0020037; GO:0098809 0 0 0 PF00042; Q5BJ29 CHOYP_NEMVEDRAFT_V1G214518.1.1 m.15909 sp FBXL7_MOUSE 27.034 381 247 7 1501 1872 117 475 1.44E-34 143 FBXL7_MOUSE reviewed F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) Fbxl7 Kiaa0840 Mus musculus (Mouse) 491 cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000086; GO:0005737; GO:0005813; GO:0007067; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q5G265 CHOYP_BRAFLDRAFT_68921.1.1 m.58205 sp NETR_SAGLB 43.388 242 126 4 4 237 365 603 1.44E-63 217 NETR_SAGLB reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Saguinus labiatus (Red-chested mustached tamarin) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5RET2 CHOYP_FKBP13.1.1 m.43694 sp FKBP7_PONAB 42.105 190 106 3 45 232 35 222 1.44E-41 144 FKBP7_PONAB reviewed Peptidyl-prolyl cis-trans isomerase FKBP7 (PPIase FKBP7) (EC 5.2.1.8) (FK506-binding protein 7) (FKBP-7) (Rotamase) FKBP7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 222 protein folding [GO:0006457] GO:0003755; GO:0005509; GO:0005788; GO:0006457 0 0 0 PF13499;PF00254; Q5UR67 CHOYP_LOC100638431.7.10 m.57953 sp RIBX_MIMIV 39.726 146 83 2 267 407 22 167 1.44E-24 102 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5XHA1 CHOYP_MD27A.2.2 m.20146 sp MED27_XENTR 40.127 314 181 4 3 312 1 311 1.44E-80 249 MED27_XENTR reviewed Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) med27 crsp8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 311 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11571; Q5YW75 CHOYP_LOC100641267.1.2 m.49206 sp ECTD_NOCFA 25.391 256 166 5 15 250 38 288 1.44E-17 84.3 ECTD_NOCFA reviewed Ectoine dioxygenase (EC 1.14.11.-) (Ectoine hydroxylase) ectD NFA_27190 Nocardia farcinica (strain IFM 10152) 298 ectoine catabolic process [GO:0042400] GO:0005506; GO:0016706; GO:0042400 0 0 0 PF05721; Q5ZKA2 CHOYP_SYIM.2.2 m.54270 sp SYIM_CHICK 42.402 691 372 10 1 675 303 983 1.44E-175 530 SYIM_CHICK reviewed "Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)" IARS2 RCJMB04_12b19 Gallus gallus (Chicken) 1000 isoleucyl-tRNA aminoacylation [GO:0006428] GO:0000049; GO:0002161; GO:0004822; GO:0005524; GO:0005739; GO:0005759; GO:0005829; GO:0006428 0 0 cd07960; PF08264;PF00133; Q6GNV7 CHOYP_BRAFLDRAFT_226012.1.1 m.4362 sp DIRC2_XENLA 37.87 338 193 6 28 358 129 456 1.44E-61 207 DIRC2_XENLA reviewed Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) 456 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6IP50 CHOYP_LOC579681.1.1 m.25827 sp UBX1A_XENLA 47.006 334 122 7 4 327 5 293 1.44E-77 242 UBX1A_XENLA reviewed UBX domain-containing protein 1-A (SAPK substrate protein 1-A) ubxn1-a saks1-a Xenopus laevis (African clawed frog) 296 0 GO:0005737 0 0 0 PF00627;PF00789; Q6TXG9 CHOYP_SFR1.1.1 m.15883 sp SFR1_RAT 37.5 112 65 2 188 294 139 250 1.44E-16 80.9 SFR1_RAT reviewed Swi5-dependent recombination DNA repair protein 1 homolog (Liver regeneration-related protein LRRGT00030) (Meiosis protein 5 homolog) Sfr1 Mei5 Meir5 Rattus norvegicus (Rat) 251 "double-strand break repair via homologous recombination [GO:0000724]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000724; GO:0005634; GO:0006351; GO:0030374; GO:0032798; GO:0045893 0 0 0 PF10376; Q6ZRF8 CHOYP_LOC100370588.16.19 m.60892 sp RN207_HUMAN 20.833 192 139 6 4 193 114 294 1.44E-07 57.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q76KX8 CHOYP_LOC100767540.1.2 m.18003 sp ZN534_HUMAN 34.1 261 159 5 431 688 398 648 1.44E-35 147 ZN534_HUMAN reviewed Zinc finger protein 534 (KRAB domain only protein 3) ZNF534 KRBO3 Homo sapiens (Human) 674 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q7PR68 CHOYP_MED7.1.1 m.48813 sp MED7_ANOGA 56.221 217 94 1 2 218 4 219 1.44E-88 263 MED7_ANOGA reviewed Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7) MED7 AGAP002823 Anopheles gambiae (African malaria mosquito) 219 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592; GO:0070847 0 0 0 PF05983; Q8BLY1 CHOYP_LOC100870584.1.1 m.50692 sp SMOC1_MOUSE 28.228 457 239 13 1 431 55 448 1.44E-39 150 SMOC1_MOUSE reviewed SPARC-related modular calcium-binding protein 1 (SPARC-related gene protein) (Secreted modular calcium-binding protein 1) (SMOC-1) Smoc1 Srg Mus musculus (Mouse) 463 cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; limb development [GO:0060173]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of osteoblast differentiation [GO:0045667]; signal transduction [GO:0007165] GO:0001654; GO:0005509; GO:0005604; GO:0007165; GO:0010811; GO:0030154; GO:0030198; GO:0045667; GO:0050840; GO:0060173 0 0 0 PF07648;PF10591;PF00086; Q8R3B7 CHOYP_BRD8.1.1 m.244 sp BRD8_MOUSE 60.123 163 53 4 510 660 756 918 1.44E-53 202 BRD8_MOUSE reviewed Bromodomain-containing protein 8 Brd8 Mus musculus (Mouse) 951 "histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; regulation of growth [GO:0040008]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000812; GO:0005654; GO:0005739; GO:0006351; GO:0006355; GO:0035267; GO:0040008; GO:0043967; GO:0043968 0 0 0 PF00439; Q8SWR3 CHOYP_CPIPJ_CPIJ000143.1.2 m.20279 sp SPR_DROME 24.625 333 223 9 61 379 86 404 1.44E-12 72.4 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q8TCB0 CHOYP_LOC100697711.1.1 m.48752 sp IFI44_HUMAN 25.498 251 174 5 130 374 179 422 1.44E-12 72.4 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q8VE97 CHOYP_SRSF4.3.6 m.13800 sp SRSF4_MOUSE 84 75 11 1 4 78 3 76 1.44E-34 126 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q8VE97 CHOYP_SRSF4.4.6 m.28748 sp SRSF4_MOUSE 84 75 11 1 4 78 3 76 1.44E-34 126 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q8VE97 CHOYP_SRSF4.5.6 m.41915 sp SRSF4_MOUSE 84 75 11 1 4 78 3 76 1.44E-34 126 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q91YX5 CHOYP_LOC100494107.1.1 m.51644 sp LGAT1_MOUSE 41.425 379 199 7 7 385 15 370 1.44E-96 295 LGAT1_MOUSE reviewed Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (EC 2.3.1.-) Lpgat1 Fam34a Mus musculus (Mouse) 370 phospholipid biosynthetic process [GO:0008654] GO:0005737; GO:0005789; GO:0008654; GO:0016020; GO:0016021; GO:0016746 0 0 0 PF16076;PF01553; Q921A2 CHOYP_LOC100373277.2.2 m.31675 sp MYCT_RAT 50.275 364 176 4 1 359 262 625 1.44E-118 360 MYCT_RAT reviewed Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) Slc2a13 Rattus norvegicus (Rat) 637 glucose import [GO:0046323]; hexose transmembrane transport [GO:0035428] GO:0005351; GO:0005355; GO:0005887; GO:0035428; GO:0046323 0 0 cd06174; PF00083; Q95JD5 CHOYP_LOC100564832.1.1 m.43026 sp ST1B1_CANLF 34.263 251 135 8 108 339 40 279 1.44E-32 126 ST1B1_CANLF reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis lupus familiaris (Dog) (Canis familiaris) 296 epithelial cell differentiation [GO:0030855]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005737; GO:0006805; GO:0008202; GO:0009812; GO:0030855; GO:0042403; GO:0051923 0 0 0 PF00685; Q96N67 CHOYP_DOCK7.2.3 m.17505 sp DOCK7_HUMAN 36.181 199 104 7 46 229 3 193 1.44E-25 108 DOCK7_HUMAN reviewed Dedicator of cytokinesis protein 7 DOCK7 KIAA1771 Homo sapiens (Human) 2140 activation of GTPase activity [GO:0090630]; axonogenesis [GO:0007409]; establishment of neuroblast polarity [GO:0045200]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; regulation of neurogenesis [GO:0050767]; small GTPase mediated signal transduction [GO:0007264] GO:0000226; GO:0005085; GO:0005622; GO:0005925; GO:0007264; GO:0007409; GO:0022027; GO:0030424; GO:0030426; GO:0031175; GO:0033138; GO:0043005; GO:0045178; GO:0045200; GO:0048365; GO:0050767; GO:0090630; GO:1904754 0 0 0 PF06920;PF14429;PF11878; Q99572 CHOYP_LOC100375753.2.2 m.43769 sp P2RX7_HUMAN 36.434 129 76 3 121 244 464 591 1.44E-15 79.3 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; Q99973 CHOYP_BRAFLDRAFT_121887.1.1 m.59668 sp TEP1_HUMAN 24.871 583 381 17 9 562 887 1441 1.44E-33 145 TEP1_HUMAN reviewed Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) 2627 telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000781; GO:0002039; GO:0003720; GO:0003723; GO:0005524; GO:0005697; GO:0005737; GO:0016363; GO:0019899; GO:0030529; GO:0070034 0 0 0 PF13271;PF05386;PF05731;PF00400; Q99ND9 CHOYP_LOC100710965.1.1 m.15140 sp RWDD1_RAT 48.472 229 111 3 1 226 1 225 1.44E-63 201 RWDD1_RAT reviewed RWD domain-containing protein 1 (Small androgen receptor-interacting protein) Rwdd1 Sarip Rattus norvegicus (Rat) 243 0 0 0 0 0 PF16543;PF05773; Q9BXJ4 CHOYP_LOC100701854.3.6 m.20033 sp C1QT3_HUMAN 36.434 129 75 5 317 442 118 242 1.44E-09 61.6 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9D5U8 CHOYP_LOC100890071.1.1 m.22589 sp CNBD2_MOUSE 30.876 217 136 4 460 673 177 382 1.44E-18 94.4 CNBD2_MOUSE reviewed Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function) Cnbd2 Cris Mus musculus (Mouse) 673 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q9FPS2 CHOYP_UBP22.2.3 m.41117 sp UBP25_ARATH 29.707 239 145 8 23 253 113 336 1.44E-18 88.2 UBP25_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (AtUBP25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) UBP25 At3g14400 MLN21.18 Arabidopsis thaliana (Mouse-ear cress) 661 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016579; GO:0036459 0 0 0 PF00443; Q9H0Z9 CHOYP_BRAFLDRAFT_215789.1.1 m.60405 sp RBM38_HUMAN 86.957 92 12 0 6 97 27 118 1.44E-55 175 RBM38_HUMAN reviewed RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4) RBM38 RNPC1 SEB4 Homo sapiens (Human) 239 "3'-UTR-mediated mRNA stabilization [GO:0070935]; cell cycle [GO:0007049]; cell cycle arrest [GO:0007050]; cell differentiation [GO:0030154]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; mRNA processing [GO:0006397]; negative regulation of cell proliferation [GO:0008285]; regulation of myotube differentiation [GO:0010830]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]" GO:0000166; GO:0003729; GO:0003730; GO:0005634; GO:0005829; GO:0006397; GO:0006977; GO:0006978; GO:0007049; GO:0007050; GO:0008285; GO:0008380; GO:0010830; GO:0030154; GO:0043484; GO:0044822; GO:0070935 0 0 0 PF00076; Q9JHA8 CHOYP_LOC101175422.1.1 m.3745 sp VWA7_MOUSE 24.967 761 457 34 18 716 26 734 1.44E-28 127 VWA7_MOUSE reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) 891 0 GO:0005576 0 0 0 0 Q9JM99 CHOYP_NEMVEDRAFT_V1G124326.1.1 m.17971 sp PRG4_MOUSE 27.624 181 97 1 71 251 454 600 1.44E-10 66.2 PRG4_MOUSE reviewed Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] Prg4 Msf Szp Mus musculus (Mouse) 1054 hematopoietic stem cell proliferation [GO:0071425]; immune response [GO:0006955]; negative regulation of interleukin-6 biosynthetic process [GO:0045409]; regulation of cell proliferation [GO:0042127] GO:0005044; GO:0005615; GO:0006955; GO:0030247; GO:0042127; GO:0045409; GO:0071425 0 0 0 PF00045;PF01033; Q9R1R2 CHOYP_BRAFLDRAFT_93856.3.6 m.32631 sp TRIM3_MOUSE 22.807 342 231 13 234 553 413 743 1.44E-08 61.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U639 CHOYP_HSPA8.1.1 m.62794 sp HSP7D_MANSE 86.7 203 27 0 1 203 410 612 1.44E-124 370 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9UGU0 CHOYP_LOC591426.1.1 m.19353 sp TCF20_HUMAN 52.941 85 40 0 1443 1527 1849 1933 1.44E-25 119 TCF20_HUMAN reviewed Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein) TCF20 KIAA0292 SPBP Homo sapiens (Human) 1960 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0008270; GO:0044212; GO:0044822; GO:0045944 0 0 0 0 Q9WVI4 CHOYP_LOC100533323.1.1 m.29518 sp GCYA2_RAT 50.095 529 259 5 213 738 170 696 1.44E-164 496 GCYA2_RAT reviewed Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) Gucy1a2 Rattus norvegicus (Rat) 730 intracellular signal transduction [GO:0035556]; positive regulation of cGMP biosynthetic process [GO:0030828]; signal transduction [GO:0007165] GO:0004383; GO:0005525; GO:0005829; GO:0005886; GO:0007165; GO:0008074; GO:0020037; GO:0030828; GO:0035556; GO:0046982 0 0 0 PF00211;PF07700;PF07701; Q9XZC8 CHOYP_LOC656741.1.1 m.19820 sp SEM2A_SCHGR 23.581 229 156 8 1 216 436 658 1.44E-09 60.5 SEM2A_SCHGR reviewed Semaphorin-2A (Sema-2A) (Sema II) SEMA-2A Schistocerca gregaria (Desert locust) 697 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005576; GO:0007399; GO:0030154 0 0 0 PF01403; Q9Y345 CHOYP_SC6A9.2.6 m.4494 sp SC6A5_HUMAN 44.231 520 258 8 1 495 258 770 1.44E-138 423 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y6N7 CHOYP_TRIADDRAFT_62089.1.2 m.39470 sp ROBO1_HUMAN 26.485 404 247 17 125 497 158 542 1.44E-19 98.6 ROBO1_HUMAN reviewed Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1) ROBO1 DUTT1 Homo sapiens (Human) 1651 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; nervous system development [GO:0007399]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Rho protein signal transduction [GO:0035025]; Roundabout signaling pathway [GO:0035385] GO:0002042; GO:0005737; GO:0005886; GO:0005887; GO:0006919; GO:0007155; GO:0007156; GO:0007399; GO:0007411; GO:0007507; GO:0008046; GO:0009986; GO:0016199; GO:0021836; GO:0030275; GO:0030336; GO:0030424; GO:0033600; GO:0035025; GO:0035385; GO:0042802; GO:0050772; GO:0050925; GO:0070100 0 0 0 PF00041;PF07679; O00222 CHOYP_LOC100374272.3.6 m.53440 sp GRM8_HUMAN 24.459 462 306 16 530 961 44 492 1.45E-27 124 GRM8_HUMAN reviewed Metabotropic glutamate receptor 8 (mGluR8) GRM8 GPRC1H MGLUR8 Homo sapiens (Human) 908 "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [GO:0007196]; negative regulation of cAMP biosynthetic process [GO:0030818]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of smell [GO:0007608]; visual perception [GO:0007601]" GO:0001642; GO:0004930; GO:0005886; GO:0005887; GO:0007196; GO:0007601; GO:0007608; GO:0008066; GO:0030818; GO:0042734; GO:0051966 0 0 0 PF00003;PF01094;PF07562; O75095 CHOYP_CED1.18.29 m.40572 sp MEGF6_HUMAN 34.584 373 226 10 50 419 639 996 1.45E-51 194 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75897 CHOYP_SULT1E1.1.3 m.15225 sp ST1C4_HUMAN 33.453 278 167 5 40 306 30 300 1.45E-39 143 ST1C4_HUMAN reviewed Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) 302 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; sulfation [GO:0051923] GO:0004062; GO:0005829; GO:0008146; GO:0050427; GO:0051923 0 0 0 PF00685; O88843 CHOYP_CRADD.1.2 m.27801 sp CRADD_MOUSE 37.778 90 53 3 6 94 1 88 1.45E-07 51.6 CRADD_MOUSE reviewed Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) Cradd Raidd Mus musculus (Mouse) 199 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; positive regulation of apoptotic signaling pathway [GO:2001235]" GO:0002020; GO:0005634; GO:0005737; GO:0006915; GO:0006919; GO:0006977; GO:0030674; GO:0070513; GO:0071260; GO:2001235 0 0 0 PF00619;PF00531; P04026 CHOYP_LOC100494049.1.8 m.6150 sp POL_IPHA 25.17 294 176 10 111 391 55 317 1.45E-06 55.1 POL_IPHA reviewed Putative Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN)] pol Hamster intracisternal a-particle H18 (IAP-H18) 863 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P08775 CHOYP_SS1G_14006.2.4 m.16538 sp RPB1_MOUSE 50.427 117 46 2 85 201 1853 1957 1.45E-19 98.6 RPB1_MOUSE reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) Polr2a Rpii215 Rpo2-1 Mus musculus (Mouse) 1970 "cellular response to oxygen levels [GO:0071453]; DNA-templated transcription, termination [GO:0006353]; piRNA metabolic process [GO:0034587]; positive regulation of RNA splicing [GO:0033120]; response to organic cyclic compound [GO:0014070]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0001047; GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0005719; GO:0006353; GO:0006366; GO:0014070; GO:0031625; GO:0033120; GO:0034587; GO:0044822; GO:0046872; GO:0071453 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; P10394 CHOYP_LOC100695950.5.6 m.17941 sp POL4_DROME 28.496 379 248 7 50 411 859 1231 1.45E-38 155 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P27393 CHOYP_CO9A1.1.1 m.62338 sp CO4A2_ASCSU 42.779 734 338 17 283 970 727 1424 1.45E-66 248 CO4A2_ASCSU reviewed Collagen alpha-2(IV) chain 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 1763 0 GO:0005201; GO:0005581; GO:0005604 0 0 0 PF01413;PF01391; P28827 CHOYP_PTPRF.2.6 m.17540 sp PTPRM_HUMAN 38.4 375 223 5 758 1126 918 1290 1.45E-73 271 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P40798 CHOYP_LOC100748395.7.7 m.62094 sp STC_DROME 48.352 91 38 2 1 88 557 641 1.45E-17 79.3 STC_DROME reviewed Protein shuttle craft stc CG3647 Drosophila melanogaster (Fruit fly) 1106 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0000977; GO:0001078; GO:0003700; GO:0003723; GO:0005634; GO:0006355; GO:0006366; GO:0008270 0 0 0 PF01424;PF01422; P50453 CHOYP_SERPINB9.1.1 m.49942 sp SPB9_HUMAN 40.263 380 217 7 1 374 1 376 1.45E-85 267 SPB9_HUMAN reviewed Serpin B9 (Cytoplasmic antiproteinase 3) (CAP-3) (CAP3) (Peptidase inhibitor 9) (PI-9) SERPINB9 PI9 Homo sapiens (Human) 376 cellular response to estrogen stimulus [GO:0071391]; immune response [GO:0006955]; mast cell mediated immunity [GO:0002448]; negative regulation by symbiont of host apoptotic process [GO:0033668]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endopeptidase activity [GO:0010951]; positive regulation of gene expression [GO:0010628]; protection from natural killer cell mediated cytotoxicity [GO:0042270]; response to bacterium [GO:0009617] GO:0002020; GO:0002448; GO:0004867; GO:0005615; GO:0005622; GO:0005634; GO:0005737; GO:0005829; GO:0006955; GO:0009617; GO:0010628; GO:0010951; GO:0016020; GO:0033668; GO:0042270; GO:0043027; GO:0043066; GO:0070062; GO:0071391 0 0 0 PF00079; P79781 CHOYP_RS27A.2.3 m.23163 sp RS27A_CHICK 96.032 126 5 0 1 126 1 126 1.45E-83 244 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; P80404 CHOYP_GABT.2.2 m.66825 sp GABT_HUMAN 51.754 228 101 2 20 238 9 236 1.45E-81 255 GABT_HUMAN reviewed "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Homo sapiens (Human) 500 aging [GO:0007568]; behavioral response to cocaine [GO:0048148]; cerebellum development [GO:0021549]; copulation [GO:0007620]; exploration behavior [GO:0035640]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; gamma-aminobutyric acid catabolic process [GO:0009450]; locomotory behavior [GO:0007626]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of platelet aggregation [GO:0090331]; neurotransmitter catabolic process [GO:0042135]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of heat generation [GO:0031652]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of uterine smooth muscle contraction [GO:0070474]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094] GO:0001666; GO:0003867; GO:0005739; GO:0005759; GO:0007568; GO:0007620; GO:0007626; GO:0009449; GO:0009450; GO:0010039; GO:0014053; GO:0021549; GO:0030170; GO:0031652; GO:0032024; GO:0032144; GO:0032145; GO:0033602; GO:0035094; GO:0035640; GO:0042135; GO:0042493; GO:0042803; GO:0043005; GO:0045471; GO:0045776; GO:0045964; GO:0046872; GO:0047298; GO:0048148; GO:0051536; GO:0070062; GO:0070474; GO:0090331; GO:0097151; GO:1902722; GO:1904450 0 0 cd00610; PF00202; Q00285 CHOYP_BRAFLDRAFT_72748.1.1 m.27724 sp GSTMU_CRILO 48.815 211 108 0 4 214 5 215 1.45E-74 227 GSTMU_CRILO reviewed Glutathione S-transferase Y1 (EC 2.5.1.18) (Chain 3) (GST class-mu) 0 Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) 218 metabolic process [GO:0008152] GO:0004364; GO:0005737; GO:0008152 0 0 0 PF00043;PF02798; Q02962 CHOYP_PAX2A.2.2 m.39524 sp PAX2_HUMAN 67.123 219 39 7 79 286 16 212 1.45E-83 270 PAX2_HUMAN reviewed Paired box protein Pax-2 PAX2 Homo sapiens (Human) 417 "aging [GO:0007568]; axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cell fate determination [GO:0001709]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; glial cell differentiation [GO:0010001]; inner ear morphogenesis [GO:0042472]; mesenchymal to epithelial transition [GO:0060231]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; mesonephros development [GO:0001823]; metanephric collecting duct development [GO:0072205]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric nephron tubule formation [GO:0072289]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cytolysis [GO:0045918]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription, DNA-templated [GO:0045892]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; optic chiasma development [GO:0061360]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; optic nerve development [GO:0021554]; optic nerve morphogenesis [GO:0021631]; optic nerve structural organization [GO:0021633]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of optic nerve formation [GO:2000597]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; protein kinase B signaling [GO:0043491]; reactive oxygen species metabolic process [GO:0072593]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of metanephros size [GO:0035566]; response to nutrient levels [GO:0031667]; retinal pigment epithelium development [GO:0003406]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; ureter development [GO:0072189]; ureter maturation [GO:0035799]; urogenital system development [GO:0001655]; vestibulocochlear nerve formation [GO:0021650]; visual perception [GO:0007601]" GO:0000987; GO:0001655; GO:0001658; GO:0001709; GO:0001823; GO:0001843; GO:0002072; GO:0003337; GO:0003406; GO:0003677; GO:0005634; GO:0005730; GO:0005764; GO:0005794; GO:0005815; GO:0006351; GO:0006366; GO:0007409; GO:0007501; GO:0007568; GO:0007601; GO:0008134; GO:0010001; GO:0016175; GO:0021554; GO:0021631; GO:0021633; GO:0021650; GO:0031667; GO:0032993; GO:0034451; GO:0035566; GO:0035799; GO:0039003; GO:0042472; GO:0043010; GO:0043066; GO:0043069; GO:0043154; GO:0043234; GO:0043491; GO:0044212; GO:0045892; GO:0045893; GO:0045918; GO:0045944; GO:0048793; GO:0048854; GO:0048863; GO:0050679; GO:0060231; GO:0061360; GO:0070301; GO:0071300; GO:0071333; GO:0071364; GO:0072075; GO:0072108; GO:0072162; GO:0072179; GO:0072189; GO:0072205; GO:0072207; GO:0072221; GO:0072289; GO:0072300; GO:0072305; GO:0072307; GO:0072593; GO:0090102; GO:0090103; GO:0090190; GO:1900212; GO:1900215; GO:1900218; GO:2000378; GO:2000594; GO:2000597 0 0 0 PF00292;PF12403; Q05360 CHOYP_WH3.1.1 m.10157 sp WHITE_LUCCU 44.496 427 226 4 63 480 99 523 1.45E-125 383 WHITE_LUCCU reviewed Protein white W Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) 677 transport [GO:0006810] GO:0005524; GO:0006810; GO:0016021; GO:0016887; GO:0031409 0 0 0 PF01061;PF00005; Q09654 CHOYP_LOC100373444.57.79 m.53326 sp TRI23_CAEEL 25.962 208 121 8 25 210 118 314 1.45E-07 56.6 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q09711 CHOYP_NCS2.1.1 m.50908 sp NCS1_SCHPO 31.183 186 122 3 1 182 1 184 1.45E-25 100 NCS1_SCHPO reviewed Calcium-binding protein NCS-1 ncs1 SPAC18B11.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 190 cellular response to calcium ion [GO:0071277]; negative regulation of calcium ion import [GO:0090281]; negative regulation of induction of conjugation with cellular fusion [GO:0010515]; positive regulation of cAMP-mediated signaling [GO:0043950]; sporulation resulting in formation of a cellular spore [GO:0030435] GO:0005509; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0010515; GO:0030435; GO:0043950; GO:0071277; GO:0090281; GO:0098744 0 0 0 PF00036;PF13499; Q14624 CHOYP_ITIH4.1.1 m.59897 sp ITIH4_HUMAN 38.502 574 335 9 30 596 33 595 1.45E-120 384 ITIH4_HUMAN reviewed Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) 930 acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; platelet degranulation [GO:0002576]; response to cytokine [GO:0034097] GO:0002576; GO:0004866; GO:0004867; GO:0005576; GO:0005886; GO:0006953; GO:0030212; GO:0031089; GO:0034097; GO:0070062; GO:0072562 0 0 0 PF06668;PF08487;PF00092; Q15061 CHOYP_LOC100368627.1.1 m.13820 sp WDR43_HUMAN 42.321 586 315 14 19 584 17 599 1.45E-144 438 WDR43_HUMAN reviewed WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog) WDR43 KIAA0007 UTP5 Homo sapiens (Human) 677 establishment of mitotic spindle orientation [GO:0000132]; microtubule organizing center organization [GO:0031023]; nuclear migration [GO:0007097]; regulation of microtubule motor activity [GO:2000574]; reproduction [GO:0000003]; rRNA processing [GO:0006364]; vesicle transport along microtubule [GO:0047496] GO:0000003; GO:0000132; GO:0000776; GO:0001650; GO:0005654; GO:0005730; GO:0005813; GO:0005874; GO:0005875; GO:0005938; GO:0006364; GO:0007097; GO:0008017; GO:0031023; GO:0044822; GO:0045502; GO:0047496; GO:2000574 0 0 0 PF04003;PF00400; Q2TA17 CHOYP_LOC100721399.1.1 m.30465 sp ZN668_BOVIN 34.375 224 137 5 167 386 195 412 1.45E-35 140 ZN668_BOVIN reviewed Zinc finger protein 668 ZNF668 Bos taurus (Bovine) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q32NC0 CHOYP_C2H18ORF21.1.1 m.763 sp CR021_HUMAN 31.746 126 80 2 1 126 1 120 1.45E-08 57 CR021_HUMAN reviewed UPF0711 protein C18orf21 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13) C18orf21 XTP13 PNAS-124 PNAS-131 Homo sapiens (Human) 220 0 0 0 0 0 PF15719; Q3T8J9 CHOYP_GON4L.1.1 m.9125 sp GON4L_HUMAN 30.223 718 358 22 165 808 273 921 1.45E-52 209 GON4L_HUMAN reviewed GON-4-like protein (GON-4 homolog) GON4L GON4 KIAA1606 Homo sapiens (Human) 2241 "B cell differentiation [GO:0030183]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003714; GO:0005634; GO:0006351; GO:0030183; GO:0045892 0 0 0 PF02671; Q460N5 CHOYP_BRAFLDRAFT_74874.1.9 m.3545 sp PAR14_HUMAN 26.23 1220 827 30 6 1204 238 1405 1.45E-108 381 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4PLW0 CHOYP_PLIN2.1.1 m.23758 sp PLIN2_PIG 27.873 409 265 10 13 405 7 401 1.45E-41 156 PLIN2_PIG reviewed Perilipin-2 (Adipophilin) (Adipose differentiation-related protein) (ADRP) PLIN2 ADFP ADRP Sus scrofa (Pig) 459 0 GO:0005622; GO:0016020 0 0 0 PF03036; Q55E58 CHOYP_BRAFLDRAFT_129004.5.15 m.33513 sp PATS1_DICDI 25.083 303 171 12 416 706 1765 2023 1.45E-16 89.4 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q568M3 CHOYP_CRLF3.2.2 m.54496 sp CRLF3_DANRE 33.619 467 261 7 2 447 5 443 1.45E-83 266 CRLF3_DANRE reviewed Cytokine receptor-like factor 3 (Clf-3 protein) crlf3 clf-3 zgc:110212 Danio rerio (Zebrafish) (Brachydanio rerio) 444 0 GO:0005737 0 0 0 0 Q5BIM1 CHOYP_LOC100115577.1.1 m.21792 sp TRI45_BOVIN 28.019 207 124 7 13 206 135 329 1.45E-08 58.5 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5K651 CHOYP_contig_017900 m.20935 sp SAMD9_HUMAN 36.139 202 114 7 579 778 162 350 1.45E-24 114 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q5NCX5 CHOYP_BLUE.1.1 m.23136 sp NEUL4_MOUSE 49.319 367 122 4 1 303 93 459 1.45E-106 344 NEUL4_MOUSE reviewed Neuralized-like protein 4 Neurl4 Kiaa1787 Mus musculus (Mouse) 1563 0 GO:0005814 0 0 0 PF07177; Q5R8Q5 CHOYP_SYT17.1.1 m.35891 sp SYT17_PONAB 49.446 451 216 6 7 448 26 473 1.45E-142 419 SYT17_PONAB reviewed Synaptotagmin-17 (Synaptotagmin XVII) (SytXVII) SYT17 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 474 cell differentiation [GO:0030154]; exocytosis [GO:0006887] GO:0006887; GO:0016020; GO:0030154 0 0 0 PF00168; Q5RJY2 CHOYP_ZGC_112970.1.1 m.62238 sp G2E3_MOUSE 24.806 258 152 8 53 288 389 626 1.45E-09 63.2 G2E3_MOUSE reviewed G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) G2e3 Kiaa1333 Mus musculus (Mouse) 716 apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0001824; GO:0005730; GO:0005737; GO:0006915; GO:0008270; GO:0016874; GO:0061630; GO:2001243 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q5VYJ5 CHOYP_CJ112.2.2 m.15806 sp MALR1_HUMAN 31.282 195 109 8 20 198 862 1047 1.45E-13 73.2 MALR1_HUMAN reviewed MAM and LDL-receptor class A domain-containing protein 1 MALRD1 C10orf112 DIET1 Homo sapiens (Human) 2156 cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858] GO:0016021; GO:0030659; GO:0042632; GO:0070858 0 0 cd06263; PF00008;PF00057;PF00629; Q60675 CHOYP_TSP_08686.1.1 m.33576 sp LAMA2_MOUSE 39.683 504 270 16 11 487 761 1257 1.45E-92 311 LAMA2_MOUSE reviewed Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) Lama2 Mus musculus (Mouse) 3118 "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; myelination in peripheral nervous system [GO:0022011]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]" GO:0005576; GO:0005604; GO:0005605; GO:0007155; GO:0007411; GO:0022011; GO:0030155; GO:0030198; GO:0030334; GO:0032224; GO:0042383; GO:0043197; GO:0045995; GO:0070062 0 0 0 PF00052;PF00053;PF00054;PF02210;PF06008;PF06009;PF00055; Q62230 CHOYP_NEMVEDRAFT_V1G50586.1.1 m.59330 sp SN_MOUSE 26.667 270 157 10 325 584 265 503 1.45E-06 56.6 SN_MOUSE reviewed Sialoadhesin (Sheep erythrocyte receptor) (SER) (Sialic acid-binding Ig-like lectin 1) (Siglec-1) (CD antigen CD169) Siglec1 Sa Sn Mus musculus (Mouse) 1695 cell adhesion [GO:0007155]; endocytosis [GO:0006897]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of T cell apoptotic process [GO:0070234] GO:0005576; GO:0005886; GO:0006897; GO:0007155; GO:0016021; GO:0030246; GO:0070234; GO:2001238 0 0 0 PF08205;PF07679;PF00047;PF13895;PF07686; Q69ZR9 CHOYP_ENOPH.1.4 m.8576 sp TASOR_MOUSE 31.719 413 247 11 87 480 94 490 1.45E-44 183 TASOR_MOUSE reviewed Protein TASOR (Transgene activation suppressor protein) Fam208a D14Abb1e Kiaa1105 Tasor Mus musculus (Mouse) 1610 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0044822 0 0 0 PF12509; Q6AWC2 CHOYP_LOC100879690.1.1 m.18064 sp WWC2_HUMAN 39.861 863 451 20 1 823 1 835 1.45E-160 514 WWC2_HUMAN reviewed Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2) WWC2 BOMB Homo sapiens (Human) 1192 negative regulation of hippo signaling [GO:0035331]; negative regulation of organ growth [GO:0046621]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122] GO:0000122; GO:0005829; GO:0019900; GO:0032947; GO:0035331; GO:0046621 0 0 0 PF00397; Q6GN58 CHOYP_LOC100176210.1.1 m.49054 sp YF1BA_XENLA 48.232 311 140 7 1 302 1 299 1.45E-98 295 YF1BA_XENLA reviewed Protein YIF1B-A (YIP1-interacting factor homolog B-A) yif1b-a Xenopus laevis (African clawed frog) 300 0 GO:0016021 0 0 0 0 Q6IP57 CHOYP_UBD2A.1.1 m.63050 sp UBD2A_XENLA 53.846 117 41 4 32 146 2 107 1.45E-29 108 UBD2A_XENLA reviewed UBA-like domain-containing protein 2-A ubald2-a fam100b-a Xenopus laevis (African clawed frog) 166 0 0 0 0 0 0 Q6JAN0 CHOYP_GPR98.2.5 m.10762 sp GPR98_DANRE 39.07 796 434 13 3 761 1671 2452 1.45E-148 485 GPR98_DANRE reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) gpr98 mass1 vlgr1 Danio rerio (Zebrafish) (Brachydanio rerio) 6199 cell surface receptor signaling pathway [GO:0007166]; eye photoreceptor cell development [GO:0042462] GO:0004930; GO:0005886; GO:0007166; GO:0016021; GO:0042462 0 0 0 PF00002;PF03160; Q6PBF0 CHOYP_RL8.4.10 m.30852 sp RL8_XENTR 84.141 227 36 0 39 265 23 249 1.45E-143 406 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q6TLE6 CHOYP_CRCM1.2.2 m.9861 sp CRCM1_DANRE 60.417 192 66 2 39 220 15 206 1.45E-77 235 CRCM1_DANRE reviewed Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) orai1 tmem142a zgc:109721 Danio rerio (Zebrafish) (Brachydanio rerio) 222 adaptive immune response [GO:0002250]; positive regulation of calcium ion transport [GO:0051928]; sarcomere organization [GO:0045214]; store-operated calcium entry [GO:0002115] GO:0002115; GO:0002250; GO:0005887; GO:0015279; GO:0016020; GO:0045214; GO:0051928 0 0 0 PF07856; Q6ZPV2 CHOYP_INO80.2.2 m.66918 sp INO80_MOUSE 60 195 57 1 40 213 445 639 1.45E-75 250 INO80_MOUSE reviewed DNA helicase INO80 (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1) Ino80 Inoc1 Kiaa1259 Mus musculus (Mouse) 1559 "cell division [GO:0051301]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mitotic sister chromatid segregation [GO:0000070]; positive regulation of cell growth [GO:0030307]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; spindle assembly [GO:0051225]; transcription, DNA-templated [GO:0006351]; UV-damage excision repair [GO:0070914]" GO:0000070; GO:0000724; GO:0003677; GO:0003678; GO:0005524; GO:0005634; GO:0005874; GO:0006302; GO:0006338; GO:0006351; GO:0010571; GO:0016887; GO:0030307; GO:0031011; GO:0034644; GO:0043014; GO:0045944; GO:0051225; GO:0051301; GO:0070914; GO:0071479; GO:2000045 0 0 0 PF13892;PF00271;PF00176; Q70E73 CHOYP_ISCW_ISCW014636.2.2 m.34179 sp RAPH1_HUMAN 37.455 550 284 14 21 547 14 526 1.45E-92 329 RAPH1_HUMAN reviewed Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1 Homo sapiens (Human) 1250 axon extension [GO:0048675]; signal transduction [GO:0007165] GO:0005737; GO:0005856; GO:0005886; GO:0007165; GO:0030027; GO:0030175; GO:0048675 0 0 0 PF00169;PF00788; Q80TE7 CHOYP_LRRC7.1.1 m.9497 sp LRRC7_MOUSE 52.749 491 218 5 1 484 7 490 1.45E-168 543 LRRC7_MOUSE reviewed Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) Lrrc7 Kiaa1365 Lap1 Mus musculus (Mouse) 1490 0 GO:0005737; GO:0014069; GO:0030054; GO:0045211 0 0 0 PF13855;PF00595; Q8IIG1 CHOYP_BRAFLDRAFT_87331.4.4 m.52728 sp YK213_PLAF7 29 100 71 0 119 218 1611 1710 1.45E-07 57.8 YK213_PLAF7 reviewed Uncharacterized protein PF11_0213 PF11_0213 Plasmodium falciparum (isolate 3D7) 2545 0 GO:0016021 0 0 0 0 Q8K3A2 CHOYP_LOC101156179.1.1 m.33242 sp TRPT1_MOUSE 42.614 176 91 6 38 204 48 222 1.45E-36 130 TRPT1_MOUSE reviewed tRNA 2'-phosphotransferase 1 (mTPT1) (EC 2.7.1.160) Trpt1 Tpt1h Mus musculus (Mouse) 249 "regulation of protein kinase activity [GO:0045859]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388; GO:0008665; GO:0045859 0 0 0 PF01885; Q925F4 CHOYP_UBOX5.1.1 m.33318 sp RNF37_MOUSE 36.792 212 121 5 1 206 1 205 1.45E-30 120 RNF37_MOUSE reviewed RING finger protein 37 (EC 6.3.2.-) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) Ubox5 Rnf37 Uip5 Mus musculus (Mouse) 539 protein polyubiquitination [GO:0000209] GO:0000209; GO:0005634; GO:0008270; GO:0016604; GO:0016874; GO:0031625; GO:0034450; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11435423}. 0 0 PF04564;PF14634; Q95230 CHOYP_LOC100373522.4.5 m.50795 sp SP17_PAPHA 43.396 159 73 4 17 165 1 152 1.45E-30 119 SP17_PAPHA reviewed Sperm surface protein Sp17 (Sperm autoantigenic protein 17) SPA17 SP17 Papio hamadryas (Hamadryas baboon) 163 binding of sperm to zona pellucida [GO:0007339] GO:0007339; GO:0016020 0 0 0 PF00612;PF02197; Q95KD7 CHOYP_LOC585913.1.1 m.14908 sp CC191_MACFA 29.96 988 570 22 9 960 16 917 1.45E-79 281 CC191_MACFA reviewed Coiled-coil domain-containing protein 191 CCDC191 QflA-14927 QtsA-14717 QtsA-16413 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 935 0 0 0 0 0 0 Q95NR9 CHOYP_CALM.16.50 m.30246 sp CALM_METSE 93.96 149 9 0 27 175 1 149 1.45E-99 286 CALM_METSE reviewed Calmodulin (CaM) 0 Metridium senile (Brown sea anemone) (Frilled sea anemone) 149 0 GO:0005509 0 0 0 PF13499; Q969V4 CHOYP_LOC100377173.1.2 m.37698 sp TEKT1_HUMAN 54.337 392 179 0 65 456 10 401 1.45E-145 425 TEKT1_HUMAN reviewed Tektin-1 TEKT1 Homo sapiens (Human) 418 0 GO:0005634; GO:0005737; GO:0005874; GO:0005929 0 0 0 0 Q96M20 CHOYP_LOC100180193.2.2 m.29817 sp CNBD2_HUMAN 24.576 236 166 5 147 374 63 294 1.45E-13 77.4 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q99JY4 CHOYP_ISCW_ISCW013325.1.2 m.5734 sp TRABD_MOUSE 44.789 355 180 5 66 406 4 356 1.45E-88 276 TRABD_MOUSE reviewed TraB domain-containing protein Trabd Mus musculus (Mouse) 376 0 0 0 0 0 PF01963; Q9BXF3 CHOYP_LOC100373268.1.1 m.56968 sp CECR2_HUMAN 31.557 469 250 13 175 583 122 579 1.45E-44 181 CECR2_HUMAN reviewed Cat eye syndrome critical region protein 2 CECR2 KIAA1740 Homo sapiens (Human) 1484 apoptotic DNA fragmentation [GO:0006309]; ATP-dependent chromatin remodeling [GO:0043044]; covalent chromatin modification [GO:0016569]; cytokinesis [GO:0000910]; cytoskeleton organization [GO:0007010]; execution phase of apoptosis [GO:0097194]; neural tube development [GO:0021915]; vesicle-mediated transport [GO:0016192] GO:0000910; GO:0005634; GO:0006309; GO:0007010; GO:0016192; GO:0016569; GO:0021915; GO:0043044; GO:0090537; GO:0097194 0 0 0 PF00439; Q9DG10 CHOYP_STAR.2.4 m.8610 sp STAR_DANRE 35.749 207 130 3 47 251 65 270 1.45E-39 141 STAR_DANRE reviewed "Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1) (StARD1)" star Danio rerio (Zebrafish) (Brachydanio rerio) 285 cholesterol metabolic process [GO:0008203]; steroid biosynthetic process [GO:0006694] GO:0005739; GO:0006694; GO:0008203; GO:0015485; GO:0017127 PATHWAY: Steroid metabolism; cholesterol metabolism. 0 cd08905; PF01852; Q9FT69 CHOYP_contig_054418 m.64910 sp RQSIM_ARATH 37.681 138 73 4 31 165 140 267 1.45E-11 66.6 RQSIM_ARATH reviewed ATP-dependent DNA helicase Q-like SIM (EC 3.6.4.12) (RecQ-like protein SIM) (AtRecQsim) (Similar to RecQ protein) RECQSIM At5g27680 T1G16.10 Arabidopsis thaliana (Mouse-ear cress) 858 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0003677; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006281; GO:0009378; GO:0043138; GO:0043140; GO:0046872 0 0 0 PF00270;PF00271;PF16124; Q9HAY6 CHOYP_BRAFLDRAFT_94883.1.1 m.4602 sp BCDO1_HUMAN 25.794 535 338 20 67 556 1 521 1.45E-37 149 BCDO1_HUMAN reviewed "Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)" BCO1 BCDO BCDO1 BCMO1 Homo sapiens (Human) 547 beta-carotene metabolic process [GO:1901810]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; vitamin A biosynthetic process [GO:0035238] GO:0001523; GO:0003834; GO:0005829; GO:0035238; GO:0042572; GO:0042574; GO:0046872; GO:1901810 PATHWAY: Cofactor metabolism; retinol metabolism. 0 0 PF03055; Q9HCS5 CHOYP_LOC100163621.2.2 m.53672 sp E41LA_HUMAN 40.872 619 274 18 39 607 15 591 1.45E-126 409 E41LA_HUMAN reviewed Band 4.1-like protein 4A (Protein NBL4) EPB41L4A EPB41L4 Homo sapiens (Human) 686 0 GO:0005737; GO:0005856; GO:0019898 0 0 0 PF08736;PF09380;PF00373;PF09379; Q9JIX8 CHOYP_ACIN1A.2.2 m.51408 sp ACINU_MOUSE 39.767 430 190 13 653 1052 844 1234 1.45E-60 231 ACINU_MOUSE reviewed Apoptotic chromatin condensation inducer in the nucleus (Acinus) Acin1 Acinus Mus musculus (Mouse) 1338 "apoptotic chromosome condensation [GO:0030263]; apoptotic process [GO:0006915]; erythrocyte differentiation [GO:0030218]; mitophagy in response to mitochondrial depolarization [GO:0098779]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of monocyte differentiation [GO:0045657]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]; xenophagy [GO:0098792]" GO:0000166; GO:0002230; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005886; GO:0006397; GO:0006915; GO:0008380; GO:0016607; GO:0030218; GO:0030263; GO:0035145; GO:0042981; GO:0043065; GO:0044822; GO:0045657; GO:0048025; GO:0061574; GO:0098779; GO:0098792 0 0 0 PF16294;PF02037; Q9NWZ3 CHOYP_LOC100169297.1.1 m.48433 sp IRAK4_HUMAN 39.103 312 164 8 299 601 166 460 1.45E-51 192 IRAK4_HUMAN reviewed Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) IRAK4 Homo sapiens (Human) 460 cytokine-mediated signaling pathway [GO:0019221]; cytokine production [GO:0001816]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of smooth muscle cell proliferation [GO:0048661]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] GO:0000287; GO:0001816; GO:0002224; GO:0002446; GO:0002755; GO:0004672; GO:0004674; GO:0005524; GO:0005615; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007254; GO:0010008; GO:0019221; GO:0034162; GO:0043123; GO:0045087; GO:0048661; GO:1990266 0 0 0 PF07714; Q9PTS8 CHOYP_CHRNA9.3.3 m.38090 sp ACHA9_CHICK 26.62 432 306 6 37 466 26 448 1.45E-57 201 ACHA9_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) CHRNA9 Gallus gallus (Chicken) 484 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005829; GO:0005892; GO:0007204; GO:0007271; GO:0022848; GO:0030054; GO:0042166; GO:0042472; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; Q9Y4R7 CHOYP_TTLL3.1.1 m.23188 sp TTLL3_HUMAN 43.713 167 86 2 1 160 448 613 1.45E-37 141 TTLL3_HUMAN reviewed Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) 772 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; protein polyglycylation [GO:0018094] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0035082; GO:0042384; GO:0070735; GO:0070736 0 0 0 PF03133; A0A0R4IBK5 CHOYP_BRAFLDRAFT_108419.2.3 m.46445 sp R213A_DANRE 30.175 401 244 11 20 413 4475 4846 1.46E-48 181 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A4IGK4 CHOYP_RBM10.1.2 m.55984 sp RBM5_XENTR 50.877 285 130 5 61 339 558 838 1.46E-85 278 RBM5_XENTR reviewed RNA-binding protein 5 (RNA-binding motif protein 5) rbm5 TGas113j08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 838 "positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal complex assembly [GO:0000245]" GO:0000166; GO:0000245; GO:0000381; GO:0003729; GO:0005634; GO:0005681; GO:0008270; GO:0043065 0 0 0 PF01585;PF00076;PF00641; B2RXS4 CHOYP_PLXNB2.1.4 m.38981 sp PLXB2_MOUSE 24.152 1267 752 62 42 1206 34 1193 1.46E-61 235 PLXB2_MOUSE reviewed Plexin-B2 Plxnb2 Mus musculus (Mouse) 1842 brain development [GO:0007420]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0001843; GO:0001932; GO:0002116; GO:0005887; GO:0007162; GO:0007405; GO:0007420; GO:0008360; GO:0009986; GO:0017154; GO:0043087; GO:0050772; GO:0070062; GO:0071526; GO:1902287; GO:2001222 0 0 0 PF08337;PF01437;PF01403;PF01833; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.6.15 m.17081 sp MLRP2_ACRMI 32.718 813 399 29 3 757 543 1265 1.46E-89 313 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E7F5E1 CHOYP_KIAA1009.1.1 m.7982 sp CE162_DANRE 31.685 890 523 16 644 1484 509 1362 1.46E-117 405 CE162_DANRE reviewed Centrosomal protein of 162 kDa (Cep162) cep162 si:ch211-198c19.2 Danio rerio (Zebrafish) (Brachydanio rerio) 1367 cilium assembly [GO:0042384] GO:0005814; GO:0005879; GO:0042384 0 0 0 0 O14815 CHOYP_CAPN9.1.1 m.9975 sp CAN9_HUMAN 38.192 686 377 14 31 700 12 666 1.46E-144 441 CAN9_HUMAN reviewed Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) (Protein CG36) CAPN9 NCL4 Homo sapiens (Human) 690 digestion [GO:0007586] GO:0004198; GO:0005509; GO:0005737; GO:0007586 0 0 0 PF01067;PF13833;PF00648; O60502 CHOYP_PHUM_PHUM456250.1.1 m.36631 sp OGA_HUMAN 42.129 667 309 11 109 732 58 690 1.46E-172 523 OGA_HUMAN reviewed Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (EC 3.2.1.-) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) MGEA5 HEXC KIAA0679 MEA5 Homo sapiens (Human) 916 glycoprotein catabolic process [GO:0006516]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517] GO:0004415; GO:0005634; GO:0005829; GO:0006044; GO:0006516; GO:0006517; GO:0016020; GO:0016231 0 0 0 PF07555; O61463 CHOYP_LOC101170669.1.1 m.48619 sp RLA2_CRYST 61.538 65 25 0 1 65 1 65 1.46E-22 87.8 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O61577 CHOYP_KTNA1.2.2 m.63438 sp KTNA1_STRPU 75.938 320 74 2 7 325 199 516 1.46E-174 496 KTNA1_STRPU reviewed Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 3.6.4.3) (p60 katanin) KATNA1 Strongylocentrotus purpuratus (Purple sea urchin) 516 cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; microtubule severing [GO:0051013]; mitotic nuclear division [GO:0007067] GO:0000922; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007067; GO:0008568; GO:0030496; GO:0031122; GO:0051013; GO:0051301 0 0 0 PF00004;PF09336; O75382 CHOYP_BRAFLDRAFT_67269.1.4 m.3768 sp TRIM3_HUMAN 19.414 649 420 22 26 590 115 744 1.46E-09 64.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0C6B8 CHOYP_NEMVEDRAFT_V1G141380.4.4 m.27939 sp SVEP1_RAT 41.85 227 102 10 1 224 1195 1394 1.46E-35 136 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P15989 CHOYP_LOC101173335.3.4 m.41618 sp CO6A3_CHICK 22.341 1965 1291 69 40 1956 38 1815 1.46E-93 344 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P16152 CHOYP_LOC100366455.1.3 m.13543 sp CBR1_HUMAN 56.458 271 117 1 293 562 7 277 1.46E-107 326 CBR1_HUMAN reviewed Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1) CBR1 CBR CRN SDR21C1 Homo sapiens (Human) 277 cyclooxygenase pathway [GO:0019371]; drug metabolic process [GO:0017144]; epithelial cell differentiation [GO:0030855]; oxidation-reduction process [GO:0055114]; vitamin K metabolic process [GO:0042373] GO:0004090; GO:0005829; GO:0016655; GO:0017144; GO:0019371; GO:0030855; GO:0042373; GO:0047021; GO:0050221; GO:0055114; GO:0070062; GO:1903561 0 0 0 PF00106; P16157 CHOYP_LOC753709.23.44 m.41545 sp ANK1_HUMAN 28.34 741 443 22 9 699 79 781 1.46E-63 233 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_LOC762964.8.10 m.54660 sp ANK1_HUMAN 29.545 616 399 6 774 1358 109 720 1.46E-73 275 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P42577 CHOYP_FRIS.10.11 m.66055 sp FRIS_LYMST 78.846 104 22 0 1 104 68 171 1.46E-55 172 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P43691 CHOYP_DERE_GG16970.1.1 m.5751 sp GATA4_CHICK 61.798 89 25 1 40 119 184 272 1.46E-29 119 GATA4_CHICK reviewed Transcription factor GATA-4 (GATA-binding factor 4) (Fragment) GATA4 Gallus gallus (Chicken) 380 "anatomical structure formation involved in morphogenesis [GO:0048646]; atrial septum secundum morphogenesis [GO:0003290]; cell development [GO:0048468]; cell fate commitment [GO:0045165]; digestive tract development [GO:0048565]; endocardial cushion development [GO:0003197]; heart development [GO:0007507]; intestinal epithelial cell differentiation [GO:0060575]; male gonad development [GO:0008584]; organ morphogenesis [GO:0009887]; positive regulation of transcription, DNA-templated [GO:0045893]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; tissue development [GO:0009888]" GO:0000977; GO:0001076; GO:0001085; GO:0001228; GO:0003197; GO:0003290; GO:0003677; GO:0003682; GO:0003713; GO:0005634; GO:0005667; GO:0007507; GO:0008270; GO:0008584; GO:0009887; GO:0009888; GO:0032526; GO:0042493; GO:0045165; GO:0045893; GO:0048468; GO:0048565; GO:0048646; GO:0060575; GO:0090575 0 0 0 PF00320;PF05349; P47959 CHOYP_HPRT.1.1 m.61881 sp HPRT_MERUN 69.302 215 66 0 46 260 4 218 1.46E-107 313 HPRT_MERUN reviewed Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) HPRT1 HPRT Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) 218 GMP catabolic process [GO:0046038]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; hypoxanthine salvage [GO:0043103]; IMP metabolic process [GO:0046040]; IMP salvage [GO:0032264]; positive regulation of dopamine metabolic process [GO:0045964]; protein homotetramerization [GO:0051289]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside salvage [GO:0006166] GO:0000166; GO:0000287; GO:0004422; GO:0005737; GO:0006164; GO:0006166; GO:0006178; GO:0032264; GO:0042803; GO:0043103; GO:0045964; GO:0046038; GO:0046040; GO:0046100; GO:0051289; GO:0052657 PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. 0 cd06223; PF00156; P53988 CHOYP_MOT8.1.2 m.16795 sp MOT2_MESAU 26.615 387 262 4 44 409 16 401 1.46E-30 127 MOT2_MESAU reviewed Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) SLC16A7 MCT2 Mesocricetus auratus (Golden hamster) 484 lactate transmembrane transport [GO:0035873]; pyruvate transmembrane transport [GO:1901475] GO:0005887; GO:0008028; GO:0015129; GO:0015293; GO:0035873; GO:0050833; GO:1901475 0 0 cd06174; PF07690; P54318 CHOYP_LOC592835.1.1 m.19699 sp LIPR2_RAT 41.716 338 182 7 27 353 5 338 1.46E-78 251 LIPR2_RAT reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) (Secretory glycoprotein GP-3) Pnliprp2 Plrp2 Rattus norvegicus (Rat) 468 galactolipid catabolic process [GO:0019376]; phospholipid catabolic process [GO:0009395]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0009395; GO:0009791; GO:0016298; GO:0019376; GO:0032094; GO:0033993; GO:0042589; GO:0043434; GO:0047372; GO:0047714; GO:0051384 0 0 0 PF00151;PF01477; P55859 CHOYP_LOC100707455.1.1 m.63410 sp PNPH_BOVIN 51.957 281 135 0 36 316 2 282 1.46E-108 320 PNPH_BOVIN reviewed Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Bos taurus (Bovine) 289 nucleoside metabolic process [GO:0009116]; purine-containing compound salvage [GO:0043101] GO:0004731; GO:0005737; GO:0005856; GO:0009116; GO:0043101 PATHWAY: Purine metabolism; purine nucleoside salvage. 0 0 PF01048; P82927 CHOYP_LOC100190042.1.1 m.11953 sp RM42_BOVIN 33.607 122 62 4 19 132 32 142 1.46E-09 55.8 RM42_BOVIN reviewed "39S ribosomal protein L42, mitochondrial (L42mt) (MRP-L42) (28S ribosomal protein S32, mitochondrial) (MRP-S32) (S32mt)" MRPL42 MRPS32 Bos taurus (Bovine) 142 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0005743; GO:0005763; GO:0005886; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF10210; P83425 CHOYP_LOC100698726.1.8 m.2784 sp HIP_MYTED 34.074 135 84 3 137 270 82 212 1.46E-11 65.5 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q01262 CHOYP_LOC100375797.1.3 m.4166 sp HYUA_PSESN 27.072 362 232 11 10 348 3 355 1.46E-25 116 HYUA_PSESN reviewed Hydantoin utilization protein A (ORF2) hyuA Pseudomonas sp. (strain NS671) 690 cellular amino acid biosynthetic process [GO:0008652] GO:0008652; GO:0016787 0 0 0 PF05378;PF01968; Q03650 CHOYP_contig_041717 m.47768 sp CRAM_TRYBB 24.595 370 279 0 5 374 218 587 1.46E-09 63.5 CRAM_TRYBB reviewed "Cysteine-rich, acidic integral membrane protein" CRAM Trypanosoma brucei brucei 945 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021; GO:0020016 0 0 0 PF07016; Q06852 CHOYP_contig_045591 m.53091 sp SLAP1_CLOTH 56.835 278 85 21 1 249 1566 1837 1.46E-21 104 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q13263 CHOYP_BRAFLDRAFT_82868.3.5 m.48837 sp TIF1B_HUMAN 27.848 158 101 5 5 157 153 302 1.46E-08 60.5 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q15262 CHOYP_PTPRZ.2.9 m.19079 sp PTPRK_HUMAN 29.333 450 296 12 1 433 983 1427 1.46E-50 188 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q29496 CHOYP_CP3AL.1.1 m.47223 sp CP3AO_SHEEP 36.735 147 88 3 15 158 276 420 1.46E-25 104 CP3AO_SHEEP reviewed Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) 503 0 GO:0004497; GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q29CT2 CHOYP_EXD.1.1 m.37482 sp EXD_DROPS 38.542 96 58 1 351 445 204 299 1.46E-09 63.2 EXD_DROPS reviewed Homeobox protein extradenticle exd GA21419 Drosophila pseudoobscura pseudoobscura (Fruit fly) 376 "eye development [GO:0001654]; peripheral nervous system development [GO:0007422]; protein import into nucleus, translocation [GO:0000060]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000060; GO:0001654; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0006357; GO:0007422; GO:0043565 0 0 0 PF00046;PF03792; Q2KJ96 CHOYP_LOC100373889.3.4 m.38002 sp ARL5A_BOVIN 32.414 145 88 4 26 170 13 147 1.46E-15 74.3 ARL5A_BOVIN reviewed ADP-ribosylation factor-like protein 5A ARL5A Bos taurus (Bovine) 179 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF00025; Q3SX45 CHOYP_TVAG_287350.5.5 m.54389 sp ASB2_BOVIN 30.516 213 128 6 261 469 169 365 1.46E-14 80.5 ASB2_BOVIN reviewed Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) 633 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q3V1T4 CHOYP_P3H2.1.1 m.467 sp P3H1_MOUSE 44.364 275 138 7 602 870 428 693 1.46E-64 235 P3H1_MOUSE reviewed Prolyl 3-hydroxylase 1 (EC 1.14.11.7) (Growth suppressor 1) (Leucine- and proline-enriched proteoglycan 1) (Leprecan-1) P3h1 Gros1 Lepre1 Mus musculus (Mouse) 739 bone development [GO:0060348]; cell growth [GO:0016049]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; negative regulation of post-translational protein modification [GO:1901874]; protein folding [GO:0006457]; protein hydroxylation [GO:0018126]; protein stabilization [GO:0050821]; regulation of ossification [GO:0030278]; regulation of protein secretion [GO:0050708] GO:0005506; GO:0005604; GO:0005634; GO:0005737; GO:0005783; GO:0005886; GO:0006457; GO:0016020; GO:0016049; GO:0018126; GO:0019797; GO:0030199; GO:0030278; GO:0031418; GO:0032963; GO:0050708; GO:0050821; GO:0060348; GO:0070062; GO:1901874 0 0 0 PF13640; Q40642 CHOYP_CML11.2.2 m.30141 sp CML1_ORYSI 36.842 133 81 1 98 230 13 142 1.46E-19 89.4 CML1_ORYSI reviewed Calmodulin-like protein 1 (OsCaM61) CML1 OsI_004066 Oryza sativa subsp. indica (Rice) 187 0 GO:0005509; GO:0016020 0 0 0 PF13499; Q4ZJM9 CHOYP_LOC100693208.1.8 m.3339 sp C1QL4_MOUSE 29.915 117 74 5 140 252 110 222 1.46E-06 51.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5EAE6 CHOYP_HS12B.7.14 m.40601 sp DAP1_BOVIN 40.741 108 57 2 52 159 1 101 1.46E-17 76.3 DAP1_BOVIN reviewed Death-associated protein 1 (DAP-1) DAP Bos taurus (Bovine) 102 apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507] GO:0006914; GO:0010507; GO:0034198; GO:0070513; GO:0097190 0 0 0 PF15228; Q5G265 CHOYP_LOC100702950.4.4 m.39316 sp NETR_SAGLB 43.165 139 76 2 1 138 367 503 1.46E-33 129 NETR_SAGLB reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Saguinus labiatus (Red-chested mustached tamarin) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5MJS3 CHOYP_LOC560397.1.1 m.9059 sp FA20C_MOUSE 56.695 351 150 2 162 511 220 569 1.46E-141 422 FA20C_MOUSE reviewed Extracellular serine/threonine protein kinase FAM20C (EC 2.7.11.1) (Dentin matrix protein 4) (DMP-4) (Golgi-enriched fraction casein kinase) (GEF-CK) Fam20c Dmp4 Kiaa4081 Mus musculus (Mouse) 579 biomineral tissue development [GO:0031214]; dentinogenesis [GO:0097187]; enamel mineralization [GO:0070166]; odontoblast differentiation [GO:0071895]; osteoclast maturation [GO:0036179]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; protein phosphorylation [GO:0006468]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; regulation of phosphorus metabolic process [GO:0051174]; skeletal system development [GO:0001501] GO:0001501; GO:0004674; GO:0005509; GO:0005524; GO:0005615; GO:0005794; GO:0006468; GO:0030145; GO:0030501; GO:0031214; GO:0036179; GO:0040036; GO:0045669; GO:0051174; GO:0070062; GO:0070166; GO:0071895; GO:0097187 0 0 0 PF06702; Q5R6P6 CHOYP_GMFB.2.2 m.54955 sp GMFB_PONAB 57.554 139 59 0 11 149 1 139 1.46E-56 176 GMFB_PONAB reviewed Glia maturation factor beta (GMF-beta) GMFB Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 142 negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316] GO:0005622; GO:0034316 0 0 0 PF00241; Q5RD86 CHOYP_DDA1.2.2 m.62929 sp DDA1_PONAB 56.122 98 43 0 22 119 1 98 1.46E-36 123 DDA1_PONAB reviewed DET1- and DDB1-associated protein 1 DDA1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 102 regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] GO:0032434 0 0 0 PF10172; Q5ZIL6 CHOYP_LOC590316.1.1 m.18476 sp TM41B_CHICK 60.075 268 105 1 10 277 1 266 1.46E-115 335 TM41B_CHICK reviewed Transmembrane protein 41B TMEM41B RCJMB04_25c20 Gallus gallus (Chicken) 269 nervous system development [GO:0007399] GO:0007399; GO:0016021 0 0 0 PF09335; Q5ZKF4 CHOYP_LOC100367548.1.1 m.48434 sp HM20A_CHICK 50.602 332 138 7 24 330 16 346 1.46E-104 313 HM20A_CHICK reviewed High mobility group protein 20A (HMG box-containing protein 20A) HMG20A RCJMB04_11c24 Gallus gallus (Chicken) 348 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF00505; Q6DE92 CHOYP_PXDC2.1.3 m.2206 sp PXDC2_XENLA 38.462 390 210 7 3 377 7 381 1.46E-74 245 PXDC2_XENLA reviewed Plexin domain-containing protein 2 plxdc2 Xenopus laevis (African clawed frog) 513 0 GO:0016021 0 0 0 PF01437; Q6NUS6 CHOYP_LOC100313750.2.2 m.59152 sp TECT3_HUMAN 27.86 542 269 26 42 554 29 477 1.46E-35 144 TECT3_HUMAN reviewed Tectonic-3 TCTN3 C10orf61 TECT3 PSEC0041 UNQ1881/PRO4324 Homo sapiens (Human) 607 apoptotic process [GO:0006915]; cilium morphogenesis [GO:0060271]; smoothened signaling pathway [GO:0007224] GO:0006915; GO:0007224; GO:0016021; GO:0060170; GO:0060271; GO:0070062 0 0 0 PF07773; Q6PZ02 CHOYP_PP1B.1.3 m.21708 sp ATG4B_CHICK 49.132 403 179 8 12 405 6 391 1.46E-134 394 ATG4B_CHICK reviewed Cysteine protease ATG4B (EC 3.4.22.-) (Autophagy-related cysteine endopeptidase 2B) (Autophagin-2B) (cAut2B) (Autophagy-related protein 4 homolog B) ATG4B APG4B AUT2B RCJMB04_12m14 Gallus gallus (Chicken) 393 autophagosome assembly [GO:0000045]; C-terminal protein lipidation [GO:0006501]; mitophagy [GO:0000422]; nucleophagy [GO:0044804]; protein delipidation [GO:0051697]; protein processing [GO:0016485]; protein targeting to membrane [GO:0006612] GO:0000045; GO:0000422; GO:0004197; GO:0005829; GO:0006501; GO:0006612; GO:0016485; GO:0044804; GO:0051697 0 0 0 PF03416; Q6ZRF8 CHOYP_LOC100374880.1.1 m.21594 sp RN207_HUMAN 26.531 196 122 8 11 199 114 294 1.46E-09 63.9 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7M3Y3 CHOYP_TNNI.3.3 m.56962 sp TNNI_CHLNI 68.067 119 34 2 646 760 159 277 1.46E-35 139 TNNI_CHLNI reviewed Troponin I (TnI) 0 Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) 292 0 GO:0005861; GO:0046872 0 0 0 PF00992; Q7TQE7 CHOYP_BRAFLDRAFT_255724.1.1 m.48762 sp K0895_MOUSE 54.573 328 149 0 118 445 185 512 1.46E-127 382 K0895_MOUSE reviewed Uncharacterized protein KIAA0895 Kiaa0895 Mus musculus (Mouse) 519 0 0 0 0 0 PF08014; Q80YF0 CHOYP_MYSP.6.9 m.40725 sp MD1L1_CRIGR 41.135 141 75 4 1 139 548 682 1.46E-22 95.5 MD1L1_CRIGR reviewed Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) MAD1L1 MAD1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 717 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; regulation of metaphase plate congression [GO:0090235] GO:0000776; GO:0000777; GO:0005634; GO:0005737; GO:0005815; GO:0007067; GO:0007094; GO:0051301; GO:0072686; GO:0090235 0 0 0 PF05557; Q8IVG5 CHOYP_LOC100368821.3.7 m.38984 sp SAM9L_HUMAN 22.646 839 529 31 3 780 804 1583 1.46E-29 130 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8IWY9 CHOYP_LOC579713.1.1 m.17438 sp CDAN1_HUMAN 34.637 1048 579 34 354 1342 193 1193 1.46E-152 499 CDAN1_HUMAN reviewed Codanin-1 CDAN1 UNQ664/PRO1295 Homo sapiens (Human) 1227 chromatin assembly [GO:0031497]; chromatin organization [GO:0006325]; negative regulation of DNA replication [GO:0008156]; protein localization [GO:0008104] GO:0005634; GO:0005737; GO:0005886; GO:0006325; GO:0008104; GO:0008156; GO:0012505; GO:0016021; GO:0031497 0 0 0 PF15296; Q8ND30 CHOYP_LOC100695320.1.2 m.1594 sp LIPB2_HUMAN 41.263 744 339 16 70 731 111 838 1.46E-167 509 LIPB2_HUMAN reviewed Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) PPFIBP2 Homo sapiens (Human) 876 0 GO:0005615; GO:0005622 0 0 0 PF00536;PF07647; Q8Q0U0 CHOYP_LOC100635111.13.13 m.64876 sp Y045_METMA 37.5 216 134 1 126 340 136 351 1.46E-38 144 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q8R1B8 CHOYP_LOC100378940.1.1 m.53792 sp RORB_MOUSE 26.154 455 276 14 24 468 7 411 1.46E-28 121 RORB_MOUSE reviewed Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) Rorb Nr1f2 Mus musculus (Mouse) 470 "amacrine cell differentiation [GO:0035881]; brain development [GO:0007420]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; eye photoreceptor cell development [GO:0042462]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; transcription, DNA-templated [GO:0006351]; visual perception [GO:0007601]" GO:0003700; GO:0003707; GO:0004879; GO:0005634; GO:0006351; GO:0007420; GO:0007601; GO:0007623; GO:0008134; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0043565; GO:0045668; GO:0045892; GO:0045893; GO:0046548; GO:0046549; GO:0060041; GO:0071300 0 0 0 PF00104;PF00105; Q8TER0 CHOYP_LOC574757.6.9 m.38145 sp SNED1_HUMAN 46.939 294 139 3 21 313 26 303 1.46E-73 270 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q92117 CHOYP_TBP.1.1 m.30116 sp TBP_PROFL 72 275 53 7 11 271 34 298 1.46E-126 364 TBP_PROFL reviewed TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) TBP Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis) 300 "DNA-templated transcription, initiation [GO:0006352]" GO:0003677; GO:0005634; GO:0006352 0 0 cd04516; PF00352; Q96MM6 CHOYP_ISCW_ISCW012626.1.4 m.21355 sp HS12B_HUMAN 36.788 193 111 5 13 199 61 248 1.46E-32 126 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9DCG9 CHOYP_RPA12.1.1 m.48818 sp TR112_MOUSE 50 100 49 1 28 127 24 122 1.46E-28 103 TR112_MOUSE reviewed Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) Trmt112 Mus musculus (Mouse) 125 peptidyl-glutamine methylation [GO:0018364]; rRNA (guanine-N7)-methylation [GO:0070476]; tRNA methylation [GO:0030488] GO:0008276; GO:0018364; GO:0030488; GO:0043234; GO:0070062; GO:0070476 0 0 0 PF03966; Q9ESN6 CHOYP_contig_046054 m.53827 sp TRIM2_MOUSE 24.686 239 154 8 129 358 523 744 1.46E-06 53.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H3F6 CHOYP_BACD3.1.1 m.54776 sp BACD3_HUMAN 78.351 97 19 1 8 102 22 118 1.46E-49 162 BACD3_HUMAN reviewed BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10) KCTD10 ULR061 MSTP028 Homo sapiens (Human) 313 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] GO:0005654; GO:0005737; GO:0016567; GO:0031463; GO:0043161; GO:0051260 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02214; Q9HCG1 CHOYP_LOC100698240.1.4 m.1241 sp ZN160_HUMAN 46.429 84 44 1 571 654 418 500 1.46E-14 81.3 ZN160_HUMAN reviewed Zinc finger protein 160 (Zinc finger protein HZF5) (Zinc finger protein Kr18) (HKr18) ZNF160 KIAA1611 Homo sapiens (Human) 818 "hemopoiesis [GO:0030097]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0030097; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q9JI92 CHOYP_LOC100375405.1.1 m.48387 sp SDCB1_RAT 55.116 303 125 3 4 300 3 300 1.46E-119 348 SDCB1_RAT reviewed Syntenin-1 (Syndecan-binding protein 1) Sdcbp Rattus norvegicus (Rat) 300 actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor internalization [GO:0002091]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346] GO:0001948; GO:0002091; GO:0005137; GO:0005634; GO:0005789; GO:0005829; GO:0005856; GO:0005886; GO:0005895; GO:0005925; GO:0007265; GO:0007268; GO:0007346; GO:0008022; GO:0008284; GO:0010718; GO:0010862; GO:0019838; GO:0030036; GO:0030307; GO:0030335; GO:0030511; GO:0032435; GO:0042043; GO:0042470; GO:0042803; GO:0045121; GO:0045545; GO:0046875; GO:0046982; GO:0050839; GO:0070062; GO:0072562; GO:1903543; GO:1903553 0 0 0 PF00595; Q9MYM7 CHOYP_B3GT2.1.1 m.35771 sp B3GT1_PONPY 32.906 234 146 3 73 303 49 274 1.46E-41 151 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9V5N8 CHOYP_FAT3.3.3 m.66403 sp STAN_DROME 29.412 238 138 11 22 246 352 572 1.46E-15 79.7 STAN_DROME reviewed Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) 3579 "axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Wnt signaling pathway [GO:0030178]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; positive regulation of Wnt signaling pathway [GO:0030177]; R3/R4 cell fate commitment [GO:0007464]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of establishment of planar polarity [GO:0090175]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" GO:0001736; GO:0001738; GO:0004872; GO:0004888; GO:0004930; GO:0005057; GO:0005509; GO:0005887; GO:0005911; GO:0007156; GO:0007164; GO:0007165; GO:0007367; GO:0007409; GO:0007411; GO:0007464; GO:0016021; GO:0016055; GO:0016318; GO:0016319; GO:0016339; GO:0016358; GO:0019233; GO:0030177; GO:0030178; GO:0035159; GO:0042067; GO:0045746; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:0090175; GO:1902669 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9VWQ2 CHOYP_LOC100858674.1.1 m.13609 sp S6KL_DROME 37.151 358 191 8 30 361 109 458 1.46E-70 232 S6KL_DROME reviewed Serine/threonine-protein kinase S6KL (EC 2.7.11.-) (Protein kinase-like 17E) (S6 kinase-like protein) S6KL Bin4 Pk17E CG7001 Drosophila melanogaster (Fruit fly) 483 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0035556 0 0 0 PF00069; Q9Y394 CHOYP_LOC100377982.1.1 m.43511 sp DHRS7_HUMAN 44.108 297 163 3 25 319 28 323 1.46E-79 248 DHRS7_HUMAN reviewed Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) 339 0 GO:0016020; GO:0016491 0 0 0 PF00106; A2AM05 CHOYP_LOC100377658.1.1 m.46674 sp CNTLN_MOUSE 28.926 1369 778 35 27 1306 119 1381 1.47E-119 409 CNTLN_MOUSE reviewed Centlein (Centrosomal protein) Cntln Mus musculus (Mouse) 1397 centriole-centriole cohesion [GO:0010457]; protein localization to organelle [GO:0033365] GO:0005737; GO:0005814; GO:0010457; GO:0019901; GO:0019904; GO:0030674; GO:0033365; GO:0070062 0 0 0 0 A7YY35 CHOYP_IFRX2.10.10 m.57957 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 1.47E-19 98.6 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; E5RJM6 CHOYP_AASI_0703.1.2 m.23831 sp ANR65_HUMAN 42.593 108 62 0 113 220 252 359 1.47E-19 89 ANR65_HUMAN reviewed Ankyrin repeat domain-containing protein 65 ANKRD65 Homo sapiens (Human) 399 0 0 0 0 0 PF12796; O14776 CHOYP_BRAFLDRAFT_117283.2.2 m.37547 sp TCRG1_HUMAN 73.188 138 36 1 2 138 961 1098 1.47E-58 198 TCRG1_HUMAN reviewed Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) TCERG1 CA150 TAF2S Homo sapiens (Human) 1098 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0001103; GO:0001106; GO:0003713; GO:0005634; GO:0005730; GO:0006366; GO:0015629; GO:0044822 0 0 0 PF01846;PF00397; O43829 CHOYP_MYNN.1.1 m.40445 sp ZBT14_HUMAN 33.019 106 67 3 500 604 277 379 1.47E-09 64.3 ZBT14_HUMAN reviewed Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) ZBTB14 ZFP161 ZNF478 Homo sapiens (Human) 449 "cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003170; GO:0003279; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0043565; GO:0044212; GO:0045892; GO:0046872; GO:0060976 0 0 0 PF00651;PF00096; P11678 CHOYP_BRAFLDRAFT_125550.5.5 m.40530 sp PERE_HUMAN 37.607 585 321 16 150 706 145 713 1.47E-119 377 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P20483 CHOYP_CDC25D.1.1 m.24457 sp MPIP_DROME 48.148 189 89 2 125 304 272 460 1.47E-53 185 MPIP_DROME reviewed M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string) stg cdc25 CG1395 Drosophila melanogaster (Fruit fly) 479 "cell division [GO:0051301]; cell proliferation [GO:0008283]; centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of cell size [GO:0045792]; negative regulation of mitotic cell cycle [GO:0045930]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; protein dephosphorylation [GO:0006470]; regulation of cell diameter [GO:0060305]; regulation of mitotic cell cycle [GO:0007346]" GO:0000086; GO:0000278; GO:0004725; GO:0005634; GO:0005694; GO:0006470; GO:0007030; GO:0007067; GO:0007099; GO:0007346; GO:0007369; GO:0007422; GO:0007424; GO:0007488; GO:0007498; GO:0008138; GO:0008283; GO:0008284; GO:0045792; GO:0045930; GO:0045931; GO:0045977; GO:0046331; GO:0051301; GO:0060305 0 0 0 PF00581; P27161 CHOYP_TSP_11726.1.2 m.1860 sp CALM_SOLLC 51.429 140 67 1 32 170 3 142 1.47E-44 147 CALM_SOLLC reviewed Calmodulin (CaM) CALM1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) 149 0 GO:0005509 0 0 0 PF13499; P27161 CHOYP_TSP_11726.2.2 m.28059 sp CALM_SOLLC 51.429 140 67 1 32 170 3 142 1.47E-44 147 CALM_SOLLC reviewed Calmodulin (CaM) CALM1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) 149 0 GO:0005509 0 0 0 PF13499; P27808 CHOYP_LOC100559184.1.1 m.9321 sp MGAT1_MOUSE 49.451 455 200 7 1 433 1 447 1.47E-163 471 MGAT1_MOUSE reviewed "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.101) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I) (GNT-I) (GlcNAc-T I)" Mgat1 Gnt1 Mus musculus (Mouse) 447 in utero embryonic development [GO:0001701]; protein glycosylation [GO:0006486]; UDP-N-acetylglucosamine catabolic process [GO:0006049] GO:0000139; GO:0001701; GO:0003827; GO:0006049; GO:0006486; GO:0008375; GO:0016020; GO:0016021; GO:0046872; GO:0070062; GO:1903561 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03071; P34416 CHOYP_LASP.1.1 m.51340 sp LASP1_CAEEL 36.986 146 77 3 15 148 180 322 1.47E-21 91.7 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P35992 CHOYP_PTPRB.4.4 m.66782 sp PTP10_DROME 30.907 783 453 27 882 1643 833 1548 1.47E-88 324 PTP10_DROME reviewed Tyrosine-protein phosphatase 10D (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 10D) (DPTP10D) Ptp10D CG1817 Drosophila melanogaster (Fruit fly) 1990 axon guidance [GO:0007411]; central nervous system development [GO:0007417]; long-term memory [GO:0007616]; motor neuron axon guidance [GO:0008045]; open tracheal system development [GO:0007424]; protein dephosphorylation [GO:0006470] GO:0004721; GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007411; GO:0007417; GO:0007424; GO:0007616; GO:0008045; GO:0016021; GO:0030424; GO:0045177 0 0 0 PF00041;PF00102; P37380 CHOYP_RL17.4.7 m.40030 sp RL17_PODCA 74.561 114 29 0 12 125 1 114 1.47E-58 184 RL17_PODCA reviewed 60S ribosomal protein L17 RPL17 Podocoryna carnea (Jellyfish) 183 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 cd00336; PF00237; P49013 CHOYP_LOC100634060.19.37 m.41798 sp FBP3_STRPU 46.479 284 145 3 307 583 122 405 1.47E-75 253 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P58270 CHOYP_DPF3.1.1 m.48615 sp DPF3_CHICK 81.982 111 20 0 67 177 305 415 1.47E-63 205 DPF3_CHICK reviewed Zinc finger protein DPF3 (Zinc finger protein cer-d4) DPF3 CERD4 Gallus gallus (Chicken) 427 "covalent chromatin modification [GO:0016569]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007399; GO:0008270; GO:0016569 0 0 0 PF00628;PF14051; P62752 CHOYP_RL23A.4.6 m.33023 sp RL23A_RAT 80.952 126 24 0 56 181 31 156 1.47E-66 203 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P62864 CHOYP_AGAP_AGAP004136.3.3 m.44420 sp RS30_RAT 86.441 59 8 0 73 131 1 59 1.47E-21 84.3 RS30_RAT reviewed 40S ribosomal protein S30 Fau Rattus norvegicus (Rat) 59 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF04758; P62864 CHOYP_MGC89853.3.7 m.25889 sp RS30_RAT 86.441 59 8 0 73 131 1 59 1.47E-21 84.3 RS30_RAT reviewed 40S ribosomal protein S30 Fau Rattus norvegicus (Rat) 59 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF04758; Q00725 CHOYP_LOC689840.1.1 m.6512 sp SGS4_DROME 33.663 101 67 0 1 101 68 168 1.47E-08 60.8 SGS4_DROME reviewed Salivary glue protein Sgs-4 Sgs4 Sgs-4 CG12181 Drosophila melanogaster (Fruit fly) 297 0 GO:0005576 0 0 0 0 Q03601 CHOYP_BRAFLDRAFT_87327.12.13 m.59609 sp NHL1_CAEEL 31.25 112 64 4 154 255 772 880 1.47E-07 55.8 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q0VCQ4 CHOYP_MRRF.1.1 m.16730 sp RRFM_BOVIN 32.68 153 101 2 135 285 79 231 1.47E-25 105 RRFM_BOVIN reviewed "Ribosome-recycling factor, mitochondrial (RRF) (Ribosome-releasing factor, mitochondrial)" MRRF Bos taurus (Bovine) 262 mitochondrial translational termination [GO:0070126] GO:0005739; GO:0043023; GO:0070126 0 0 0 PF01765; Q13393 CHOYP_LOC658196.1.2 m.18567 sp PLD1_HUMAN 40.464 388 209 7 66 438 41 421 1.47E-94 310 PLD1_HUMAN reviewed Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) PLD1 Homo sapiens (Human) 1074 cell motility [GO:0048870]; chemotaxis [GO:0006935]; inositol lipid-mediated signaling [GO:0048017]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0004630; GO:0005765; GO:0005768; GO:0005789; GO:0005794; GO:0006654; GO:0006935; GO:0007264; GO:0007265; GO:0016020; GO:0016042; GO:0016324; GO:0030139; GO:0031902; GO:0032534; GO:0035091; GO:0048017; GO:0048471; GO:0048870; GO:0070290 0 0 0 PF00169;PF00614;PF13091;PF00787; Q16534 CHOYP_LOC726528.2.2 m.17967 sp HLF_HUMAN 56.164 73 32 0 141 213 219 291 1.47E-19 87.8 HLF_HUMAN reviewed Hepatic leukemia factor HLF Homo sapiens (Human) 295 multicellular organism development [GO:0007275]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000977; GO:0001077; GO:0003677; GO:0003690; GO:0005634; GO:0006366; GO:0007275; GO:0035914; GO:0048511 0 0 0 PF07716; Q1EG27 CHOYP_MYO3B.1.1 m.65666 sp MYO3B_MOUSE 34.683 741 419 16 1 710 400 1106 1.47E-111 387 MYO3B_MOUSE reviewed Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) 1305 peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0000146; GO:0001750; GO:0001917; GO:0004674; GO:0005524; GO:0005737; GO:0007601; GO:0016459; GO:0018105; GO:0018107; GO:0032426; GO:0032433; GO:0046777; GO:0050896; GO:0051491 0 0 0 PF00612;PF00063;PF00069; Q1L981 CHOYP_BRAFLDRAFT_125731.1.1 m.6261 sp TDRD5_DANRE 33.607 122 69 4 2 118 5 119 1.47E-06 55.8 TDRD5_DANRE reviewed Tudor domain-containing protein 5 tdrd5 si:dkey-171o17.7 Danio rerio (Zebrafish) (Brachydanio rerio) 905 DNA methylation involved in gamete generation [GO:0043046]; P granule organization [GO:0030719]; spermatid development [GO:0007286] GO:0007286; GO:0030719; GO:0033391; GO:0043046; GO:0071546 0 0 0 PF12872;PF00567; Q24342 CHOYP_RFNG.1.1 m.34921 sp FNG_DROME 53.558 267 114 5 111 368 144 409 1.47E-98 301 FNG_DROME reviewed Fringe glycosyltransferase (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) fng CG10580 Drosophila melanogaster (Fruit fly) 412 "cell fate specification [GO:0001708]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; cuticle pattern formation [GO:0035017]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; female germ-line stem cell population maintenance [GO:0036099]; fucose metabolic process [GO:0006004]; germarium-derived egg chamber formation [GO:0007293]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; protein O-linked glycosylation [GO:0006493]; regulation of Notch signaling pathway [GO:0008593]; wing disc dorsal/ventral pattern formation [GO:0048190]" GO:0001708; GO:0001745; GO:0005783; GO:0005794; GO:0005795; GO:0005797; GO:0006004; GO:0006493; GO:0007219; GO:0007293; GO:0007450; GO:0007451; GO:0007476; GO:0008194; GO:0008375; GO:0008587; GO:0008593; GO:0030173; GO:0033829; GO:0035017; GO:0036011; GO:0036099; GO:0045746; GO:0046872; GO:0048190; GO:0048477; GO:0048749 0 0 0 PF02434; Q28983 CHOYP_LOC100147904.1.1 m.53615 sp ZAN_PIG 27.813 1431 784 47 32 1434 700 1909 1.47E-137 473 ZAN_PIG reviewed Zonadhesin ZAN Sus scrofa (Pig) 2476 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840 0 0 cd06263; PF08742;PF00008;PF00629;PF01826;PF12714;PF00094; Q2KID0 CHOYP_EXOSC2.1.1 m.9530 sp EXOS2_BOVIN 66.899 287 94 1 1 287 3 288 1.47E-141 403 EXOS2_BOVIN reviewed Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4) EXOSC2 RRP4 Bos taurus (Bovine) 293 "CUT catabolic process [GO:0071034]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [GO:0071049]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; U4 snRNA 3'-end processing [GO:0034475]" GO:0000176; GO:0000177; GO:0000178; GO:0000467; GO:0003723; GO:0005730; GO:0030307; GO:0034427; GO:0034475; GO:0043928; GO:0071034; GO:0071035; GO:0071038; GO:0071049; GO:0071051 0 0 0 PF14382;PF15985; Q3URE9 CHOYP_LIGO2.2.2 m.26428 sp LIGO2_MOUSE 27.919 394 247 14 46 418 188 565 1.47E-28 124 LIGO2_MOUSE reviewed Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (Leucine-rich repeat neuronal protein 6C) Lingo2 Lrrn6c Mus musculus (Mouse) 606 positive regulation of synapse assembly [GO:0051965] GO:0016021; GO:0051965 0 0 0 PF07679;PF13855;PF01462; Q4UMH6 CHOYP_TNI3K.2.2 m.55037 sp Y381_RICFE 24.138 377 236 11 266 613 635 990 1.47E-19 97.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q4UMH6 CHOYP_TVAG_178480.1.2 m.32294 sp Y381_RICFE 22.989 522 339 18 11 511 673 1152 1.47E-15 84.7 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q52L34 CHOYP_MTHSD.2.2 m.46743 sp MTHSD_XENLA 34.783 69 45 0 40 108 312 380 1.47E-08 55.1 MTHSD_XENLA reviewed Methenyltetrahydrofolate synthase domain-containing protein mthfsd Xenopus laevis (African clawed frog) 415 0 GO:0000166; GO:0003723 0 0 0 PF01812; Q5DU00 CHOYP_DCDC2.6.7 m.46323 sp DCDC2_MOUSE 29.676 401 234 13 2 385 6 375 1.47E-35 144 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q5F3D7 CHOYP_UTP15.1.1 m.12922 sp UTP15_CHICK 48.577 492 250 2 98 586 13 504 1.47E-176 513 UTP15_CHICK reviewed U3 small nucleolar RNA-associated protein 15 homolog UTP15 RCJMB04_20m16 Gallus gallus (Chicken) 520 rRNA processing [GO:0006364] GO:0005730; GO:0005737; GO:0006364; GO:0030054; GO:0044822 0 0 0 PF09384;PF00400; Q5PQ44 CHOYP_BRAFLDRAFT_122572.1.1 m.29320 sp CD022_XENLA 71.674 233 64 2 16 248 3 233 1.47E-120 345 CD022_XENLA reviewed Uncharacterized protein C4orf22 homolog 0 Xenopus laevis (African clawed frog) 233 0 0 0 0 0 PF14713; Q5UQ35 CHOYP_LOC100378011.2.2 m.52041 sp YR811_MIMIV 30.233 215 112 10 19 214 3 198 1.47E-14 78.2 YR811_MIMIV reviewed Putative ariadne-like RING finger protein R811 MIMI_R811 Acanthamoeba polyphaga mimivirus (APMV) 990 0 GO:0008270 0 0 0 PF01485; Q60PP8 CHOYP_CPLX.1.1 m.38565 sp CPLX1_CAEBR 54.321 81 33 2 22 102 34 110 1.47E-17 75.9 CPLX1_CAEBR reviewed Putative complexin-1 cpx-1 CBG22157 Caenorhabditis briggsae 143 exocytosis [GO:0006887]; neurotransmitter transport [GO:0006836] GO:0005829; GO:0006836; GO:0006887 0 0 0 PF05835; Q62172 CHOYP_RBP1A.1.1 m.24423 sp RBP1_MOUSE 52.113 284 136 0 110 393 175 458 1.47E-90 302 RBP1_MOUSE reviewed RalA-binding protein 1 (RalBP1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1) Ralbp1 Rip1 Mus musculus (Mouse) 648 endocytosis [GO:0006897]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; small GTPase mediated signal transduction [GO:0007264]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005096; GO:0005622; GO:0006810; GO:0006897; GO:0007264; GO:0016020; GO:0016887; GO:0017160; GO:0022857; GO:0043087; GO:0043547; GO:0048365; GO:0055085 0 0 0 PF00620; Q64649 CHOYP_LOC100368228.2.3 m.23230 sp KPB1_RAT 43.333 150 74 4 30 176 726 867 1.47E-26 108 KPB1_RAT reviewed "Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)" Phka1 Rattus norvegicus (Rat) 1242 glycogen metabolic process [GO:0005977]; phosphatidylcholine biosynthetic process [GO:0006656]; protein autophosphorylation [GO:0046777] GO:0004105; GO:0005886; GO:0005964; GO:0005977; GO:0006656; GO:0046777 PATHWAY: Glycan biosynthesis; glycogen metabolism. 0 0 PF00723; Q68EM7 CHOYP_RHG17.2.2 m.40528 sp RHG17_HUMAN 49.558 452 219 5 1 447 19 466 1.47E-146 443 RHG17_HUMAN reviewed Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) ARHGAP17 RICH1 MSTP066 MSTP110 Homo sapiens (Human) 881 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0005886; GO:0005923; GO:0007165; GO:0051056 0 0 0 PF03114;PF00620; Q6NYM1 CHOYP_KLH21.1.1 m.51631 sp KLH21_DANRE 35.409 562 333 9 16 568 20 560 1.47E-108 340 KLH21_DANRE reviewed Kelch-like protein 21 klhl21 zgc:76933 Danio rerio (Zebrafish) (Brachydanio rerio) 613 cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cytokinesis [GO:0032465] GO:0005737; GO:0005827; GO:0007067; GO:0016567; GO:0031463; GO:0032465; GO:0035853; GO:0042787; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6PDJ1 CHOYP_NEMVEDRAFT_V1G238894.10.11 m.62616 sp CAHD1_MOUSE 25.645 698 459 20 19 678 467 1142 1.47E-54 207 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6R7G0 CHOYP_ABHV_ORF25.1.3 m.7910 sp Y068_OSHVF 19.103 691 468 17 528 1132 1 686 1.47E-30 133 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q82IZ1 CHOYP_BRAFLDRAFT_63281.1.2 m.28725 sp PTLH_STRAW 22.472 267 161 12 41 290 19 256 1.47E-07 55.8 PTLH_STRAW reviewed 1-deoxypentalenic acid 11-beta-hydroxylase (EC 1.14.11.35) (Neopentalenolactone biosynthesis protein H) ptlH SAV_2991 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 285 antibiotic biosynthetic process [GO:0017000]; lactone biosynthetic process [GO:1901336]; oxidation-reduction process [GO:0055114] GO:0005506; GO:0016706; GO:0017000; GO:0031418; GO:0055114; GO:1901336 PATHWAY: Antibiotic biosynthesis; neopentalenolactone biosynthesis. {ECO:0000269|PubMed:21250661}. 0 0 PF05721; Q86WV6 CHOYP_UNC89.7.19 m.34187 sp STING_HUMAN 33.152 184 113 6 997 1172 154 335 1.47E-18 92.8 STING_HUMAN reviewed Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) 379 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of type I interferon production [GO:0032479]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005789; GO:0005794; GO:0005886; GO:0006915; GO:0008134; GO:0016021; GO:0019901; GO:0030659; GO:0032092; GO:0032479; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042802; GO:0042803; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; Q8BIE6 CHOYP_LOC100369109.1.2 m.6756 sp FRM4A_MOUSE 50 548 231 5 2 547 1 507 1.47E-179 542 FRM4A_MOUSE reviewed FERM domain-containing protein 4A Frmd4a Frmd4 Kiaa1294 Mus musculus (Mouse) 1020 establishment of epithelial cell polarity [GO:0090162] GO:0005737; GO:0005856; GO:0005923; GO:0030674; GO:0090162 0 0 0 PF11819;PF09380;PF00373;PF09379; Q8BV79 CHOYP_NEMVEDRAFT_V1G79745.3.3 m.59918 sp TRNK1_MOUSE 43.229 192 103 4 4 191 962 1151 1.47E-48 173 TRNK1_MOUSE reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1) Trank1 Gm187 Kiaa0342 Lba1 Mus musculus (Mouse) 2999 0 0 0 0 0 0 Q8BYR1 CHOYP_LOC587803.1.1 m.9452 sp TYW4_MOUSE 39.651 459 248 12 26 463 6 456 1.47E-96 319 TYW4_MOUSE reviewed tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (p21WAF1/CIP1 promoter-interacting protein) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase) Lcmt2 Kiaa0547 Tyw4 Mus musculus (Mouse) 686 C-terminal protein methylation [GO:0006481]; tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591] GO:0003880; GO:0005829; GO:0006481; GO:0008175; GO:0008757; GO:0030488; GO:0031591 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 PF04072; Q8C8H8 CHOYP_LOC100901500.3.3 m.60010 sp KY_MOUSE 27.11 391 236 16 255 635 136 487 1.47E-30 132 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8CI51 CHOYP_contig_032576 m.37192 sp PDLI5_MOUSE 31.191 638 320 17 19 602 13 585 1.47E-86 284 PDLI5_MOUSE reviewed PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) Pdlim5 Enh Mus musculus (Mouse) 591 regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synapse assembly [GO:0051963] GO:0005829; GO:0008270; GO:0014069; GO:0015629; GO:0030018; GO:0030054; GO:0043005; GO:0045211; GO:0051963; GO:0061001 0 0 0 PF15936;PF00412;PF00595; Q8IYX7 CHOYP_LOC100890512.1.1 m.36422 sp SAXO1_HUMAN 30.786 471 312 8 3 463 4 470 1.47E-64 218 SAXO1_HUMAN reviewed Stabilizer of axonemal microtubules 1 SAXO1 C9orf138 FAM154A Homo sapiens (Human) 474 cell projection organization [GO:0030030]; cellular response to cold [GO:0070417]; cold acclimation [GO:0009631]; positive regulation of cilium assembly [GO:0045724] GO:0005814; GO:0005879; GO:0008017; GO:0009631; GO:0030030; GO:0031512; GO:0036064; GO:0036126; GO:0045724; GO:0070417 0 0 0 0 Q8JHV9 CHOYP_BIRC2.8.13 m.52543 sp BIR7A_XENLA 29.582 311 157 7 504 800 139 401 1.47E-39 154 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8K0U4 CHOYP_LOC100207121.6.9 m.58257 sp HS12A_MOUSE 29.264 516 264 14 64 516 196 673 1.47E-57 206 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.4.34 m.4995 sp VWDE_HUMAN 22.304 677 419 25 27 650 32 654 1.47E-22 108 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TCT0 CHOYP_CERKL.3.4 m.60276 sp CERK1_HUMAN 28.788 264 179 4 38 294 50 311 1.47E-35 141 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q8WQI5 CHOYP_RS8.14.14 m.65950 sp RS8_SPOFR 71.905 210 57 1 1 210 1 208 1.47E-107 310 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q95V39 CHOYP_RL8.2.10 m.14508 sp RL8_SPOFR 85.87 92 13 0 1 92 165 256 1.47E-49 160 RL8_SPOFR reviewed 60S ribosomal protein L8 RpL8 Spodoptera frugiperda (Fall armyworm) 257 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00181;PF03947; Q99M80 CHOYP_PTPRK.10.20 m.31769 sp PTPRT_MOUSE 32.554 556 340 12 506 1045 755 1291 1.47E-75 276 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99NH0 CHOYP_LOC753709.15.44 m.28900 sp ANR17_MOUSE 31.204 407 243 14 10 405 299 679 1.47E-32 140 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9CQW0 CHOYP_LOC100369729.1.3 m.6693 sp EMC6_MOUSE 66.019 103 35 0 26 128 8 110 1.47E-38 129 EMC6_MOUSE reviewed ER membrane protein complex subunit 6 (Transmembrane protein 93) Emc6 Tmem93 Mus musculus (Mouse) 110 autophagosome assembly [GO:0000045]; protein folding in endoplasmic reticulum [GO:0034975] GO:0000045; GO:0016021; GO:0030176; GO:0034975; GO:0072546; GO:0097631 0 0 0 PF07019; Q9D995 CHOYP_LOC100635066.1.1 m.45465 sp CNTD1_MOUSE 33.213 277 183 2 22 296 24 300 1.47E-42 152 CNTD1_MOUSE reviewed Cyclin N-terminal domain-containing protein 1 Cntd1 Cntd Mus musculus (Mouse) 334 reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283] GO:0007131; GO:0007283 0 0 0 PF00134; Q9ESN6 CHOYP_BRAFLDRAFT_92727.7.17 m.32799 sp TRIM2_MOUSE 29.05 179 116 5 74 248 536 707 1.47E-10 64.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GZQ3 CHOYP_BRAFLDRAFT_132957.1.1 m.51287 sp COMD5_HUMAN 43.333 210 119 0 11 220 15 224 1.47E-59 189 COMD5_HUMAN reviewed COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) COMMD5 HT002 Homo sapiens (Human) 224 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355 0 0 0 PF07258; Q9MYM7 CHOYP_LOC100562203.1.1 m.6737 sp B3GT1_PONPY 37.879 264 155 5 106 367 60 316 1.47E-55 188 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9NQ86 CHOYP_TRI33.8.8 m.66915 sp TRI36_HUMAN 28.689 122 74 4 5 118 149 265 1.47E-07 53.1 TRI36_HUMAN reviewed E3 ubiquitin-protein ligase TRIM36 (EC 6.3.2.-) (RING finger protein 98) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) TRIM36 RBCC728 RNF98 Homo sapiens (Human) 728 acrosome reaction [GO:0007340]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726] GO:0000209; GO:0001669; GO:0004842; GO:0005829; GO:0005856; GO:0007340; GO:0008270; GO:0016874; GO:0051726; GO:0070062 0 0 0 PF00041;PF00643;PF13445; Q9NTZ6 CHOYP_ISCW_ISCW006831.1.1 m.23820 sp RBM12_HUMAN 57.471 87 37 0 1 87 1 87 1.47E-22 108 RBM12_HUMAN reviewed RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN) RBM12 KIAA0765 HRIHFB2091 Homo sapiens (Human) 932 0 GO:0000166; GO:0005654; GO:0044822 0 0 0 PF00076; Q9P2C4 CHOYP_LOC100375472.1.1 m.61867 sp TM181_HUMAN 42.233 206 104 4 45 250 144 334 1.47E-41 152 TM181_HUMAN reviewed Transmembrane protein 181 TMEM181 GPR178 KIAA1423 Homo sapiens (Human) 612 pathogenesis [GO:0009405] GO:0009405; GO:0015643; GO:0016021 0 0 0 0 Q9TXQ1 CHOYP_LOC588883.1.3 m.1231 sp TNKS1_CAEEL 28.329 353 237 12 123 471 84 424 1.47E-15 83.6 TNKS1_CAEEL reviewed Tankyrase-like protein (EC 2.4.2.30) (Poly ADP-ribose metabolism enzyme 5) (Poly(ADP-ribose) polymerase pme-5) tank-1 pme-5 ZK1005.1 Caenorhabditis elegans 2276 cellular response to DNA damage stimulus [GO:0006974]; DNA ligation involved in DNA repair [GO:0051103]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lagging strand elongation [GO:0006273]; negative regulation of programmed cell death [GO:0043069]; protein ADP-ribosylation [GO:0006471]; response to gamma radiation [GO:0010332] GO:0003910; GO:0003950; GO:0005634; GO:0005694; GO:0005737; GO:0006273; GO:0006471; GO:0006974; GO:0008630; GO:0010332; GO:0043069; GO:0051103 0 0 0 PF12796;PF00644;PF02877;PF05406; Q9U8M0 CHOYP_LOC100376142.1.1 m.18173 sp VIT1_PERAM 21.531 209 147 2 12 207 94 298 1.47E-10 66.6 VIT1_PERAM reviewed Vitellogenin-1 (Vg-1) VG2 VG Periplaneta americana (American cockroach) (Blatta americana) 1896 0 GO:0005319; GO:0005576; GO:0045735 0 0 0 PF09172;PF01347;PF00094; Q9UMZ3 CHOYP_LOC100491367.1.3 m.36555 sp PTPRQ_HUMAN 23.718 624 330 19 786 1311 160 735 1.47E-25 119 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; Q9VVY3 CHOYP_GBS76.1.1 m.1572 sp GBS76_DROME 47.826 207 99 4 237 437 437 640 1.47E-51 187 GBS76_DROME reviewed Glycogen-binding subunit 76A (CBM21 domain-containing protein CG9619) Gbs-76A CG9619 Drosophila melanogaster (Fruit fly) 681 0 GO:0008157 0 0 0 PF03370; Q9WUP7 CHOYP_UCHL5.2.2 m.46419 sp UCHL5_MOUSE 65.758 330 100 2 40 357 1 329 1.47E-162 460 UCHL5_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5) Uchl5 Uch37 Mus musculus (Mouse) 329 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; forebrain morphogenesis [GO:0048853]; lateral ventricle development [GO:0021670]; midbrain development [GO:0030901]; protein deubiquitination [GO:0016579]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0000502; GO:0004843; GO:0004866; GO:0005634; GO:0005737; GO:0005829; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0006511; GO:0016579; GO:0021670; GO:0030901; GO:0031011; GO:0044822; GO:0048853; GO:0061136; GO:0070628 0 0 0 PF01088; A4FU69 CHOYP_NEMVEDRAFT_V1G167853.1.2 m.20047 sp EFCB5_HUMAN 40.501 679 374 9 633 1286 805 1478 1.48E-166 539 EFCB5_HUMAN reviewed EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) 1503 0 GO:0005509 0 0 0 0 A4IF63 CHOYP_BRAFLDRAFT_117226.1.2 m.3226 sp TRIM2_BOVIN 32.075 106 68 3 24 126 627 731 1.48E-07 52.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6H694 CHOYP_LOC757199.1.1 m.42843 sp LRC63_MOUSE 43.58 257 141 2 185 441 349 601 1.48E-65 225 LRC63_MOUSE reviewed Leucine-rich repeat-containing protein 63 Lrrc63 Mus musculus (Mouse) 637 0 0 0 0 0 PF13855; A7YY35 CHOYP_IFRX2.6.10 m.30819 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 1.48E-19 98.6 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; B3EWY9 CHOYP_LOC590125.3.7 m.34487 sp MLP_ACRMI 26.951 1243 720 46 69 1227 225 1363 1.48E-92 337 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B5XWV7 CHOYP_NEMVEDRAFT_V1G236873.1.1 m.19636 sp RIHA_KLEP3 34.416 308 191 9 6 310 5 304 1.48E-40 147 RIHA_KLEP3 reviewed Pyrimidine-specific ribonucleoside hydrolase RihA (EC 3.2.-.-) (Cytidine/uridine-specific hydrolase) rihA KPK_2440 Klebsiella pneumoniae (strain 342) 311 nucleobase-containing small molecule interconversion [GO:0015949]; pyrimidine nucleobase metabolic process [GO:0006206] GO:0005737; GO:0006206; GO:0015949; GO:0045437 0 0 0 PF01156; D2GXS7 CHOYP_AIMP1.1.1 m.16359 sp TRIM2_AILME 30.488 246 160 4 124 362 463 704 1.48E-23 107 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_contig_017627 m.20645 sp TRIM2_AILME 23.077 143 105 3 351 489 602 743 1.48E-06 54.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZHA0 CHOYP_FLNA.4.6 m.27031 sp FLNC_RAT 28.425 1365 815 44 22 1274 33 1347 1.48E-120 419 FLNC_RAT reviewed Filamin-C (FLN-C) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) Flnc Abpl Fln2 Rattus norvegicus (Rat) 2726 muscle fiber development [GO:0048747] GO:0005856; GO:0005925; GO:0016528; GO:0030018; GO:0030506; GO:0042383; GO:0043034; GO:0048747 0 0 0 PF00307;PF00630; E1BD59 CHOYP_SOX2.1.2 m.31412 sp TRI56_BOVIN 25.843 267 150 9 21 257 14 262 1.48E-13 73.6 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O43663 CHOYP_BRAFLDRAFT_124259.1.1 m.18849 sp PRC1_HUMAN 37.903 620 356 9 44 644 7 616 1.48E-127 393 PRC1_HUMAN reviewed Protein regulator of cytokinesis 1 PRC1 Homo sapiens (Human) 620 cytokinesis [GO:0000910]; microtubule bundle formation [GO:0001578]; mitotic spindle elongation [GO:0000022]; positive regulation of cell proliferation [GO:0008284] GO:0000022; GO:0000910; GO:0000922; GO:0001578; GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0005829; GO:0005876; GO:0005886; GO:0008284; GO:0015630; GO:0019894; GO:0019901; GO:0030496; GO:0042802; GO:0070938 0 0 0 0 O70133 CHOYP_ISCW_ISCW009103.1.1 m.24140 sp DHX9_MOUSE 49.091 220 89 6 16 221 1 211 1.48E-55 194 DHX9_MOUSE reviewed ATP-dependent RNA helicase A (RHA) (EC 3.6.4.13) (DEAH box protein 9) (mHEL-5) (Nuclear DNA helicase II) (NDH II) Dhx9 Ddx9 Mus musculus (Mouse) 1380 cellular response to heat [GO:0034605]; circadian rhythm [GO:0007623]; CRD-mediated mRNA stabilization [GO:0070934]; osteoblast differentiation [GO:0001649]; protein localization to cytoplasmic stress granule [GO:1903608]; RNA processing [GO:0006396] GO:0001085; GO:0001649; GO:0003677; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0006396; GO:0007623; GO:0016020; GO:0030529; GO:0034605; GO:0036464; GO:0044822; GO:0070934; GO:0070937; GO:0097165; GO:1903608 0 0 0 PF00270;PF00035;PF04408;PF00271;PF07717; O77302 CHOYP_RS10.2.5 m.2186 sp RS10_LUMRU 73.034 89 16 2 14 99 68 151 1.48E-34 119 RS10_LUMRU reviewed 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) 156 0 GO:0005840 0 0 0 PF03501; O93479 CHOYP_ORC4.1.1 m.18901 sp ORC4_XENLA 59.596 396 158 2 69 462 37 432 1.48E-174 499 ORC4_XENLA reviewed Origin recognition complex subunit 4 orc4 orc4l Xenopus laevis (African clawed frog) 432 DNA replication [GO:0006260] GO:0003677; GO:0005524; GO:0005664; GO:0006260 0 0 0 PF14629; O93603 CHOYP_SMP_129810.1.2 m.6853 sp TRFR_CHICK 25.087 287 197 8 1 273 1 283 1.48E-11 68.2 TRFR_CHICK reviewed Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Gallus gallus (Chicken) 395 0 GO:0004997; GO:0005886; GO:0016021 0 0 0 PF00001; O97341 CHOYP_CAM.1.1 m.38106 sp CALM_SUBDO 50.926 108 52 1 2 109 40 146 1.48E-34 119 CALM_SUBDO reviewed Calmodulin (CaM) 0 Suberites domuncula (Sponge) 149 0 GO:0005509 0 0 0 PF13499; P13813 CHOYP_LOC100375776.3.3 m.33160 sp 110KD_PLAKN 43.976 166 93 0 203 368 131 296 1.48E-25 111 110KD_PLAKN reviewed 110 kDa antigen (PK110) (Fragment) 0 Plasmodium knowlesi 296 0 0 0 0 0 0 P31320 CHOYP_LOC100371136.1.5 m.26320 sp KAPR_BLAEM 26.012 173 111 3 123 285 215 380 1.48E-08 61.2 KAPR_BLAEM reviewed cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) PKAR Blastocladiella emersonii (Aquatic fungus) 403 0 GO:0005952; GO:0008603; GO:0030552 0 0 0 PF00027;PF02197; P45961 CHOYP_AAEL_AAEL010792.2.2 m.51401 sp CEX2_CAEEL 30.256 195 116 3 60 250 11 189 1.48E-22 94.4 CEX2_CAEEL reviewed Calexcitin-2 cex-2 T09A5.1 Caenorhabditis elegans 189 0 GO:0005509 0 0 0 0 P56380 CHOYP_LOC658593.1.1 m.25202 sp AP4A_MOUSE 44.444 135 68 2 18 146 5 138 1.48E-37 128 AP4A_MOUSE reviewed "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] (EC 3.6.1.17) (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Ap4A hydrolase) (Ap4Aase) (Diadenosine tetraphosphatase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)" Nudt2 Apah1 Mus musculus (Mouse) 147 apoptotic process [GO:0006915] GO:0004081; GO:0005525; GO:0005739; GO:0006915 0 0 0 PF00293; P60901 CHOYP_PSA6.1.1 m.30357 sp PSA6_RAT 82.114 246 44 0 1 246 1 246 1.48E-155 434 PSA6_RAT reviewed Proteasome subunit alpha type-6 (EC 3.4.25.1) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) Psma6 Rattus norvegicus (Rat) 246 positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteolysis involved in cellular protein catabolic process [GO:0051603]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000932; GO:0003723; GO:0004298; GO:0005634; GO:0005839; GO:0005844; GO:0006511; GO:0016363; GO:0019773; GO:0030016; GO:0030017; GO:0051092; GO:0051603 0 0 0 PF00227;PF10584; Q05695 CHOYP_LOC100901941.1.3 m.54073 sp L1CAM_RAT 24.769 432 276 18 52 458 52 459 1.48E-25 115 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q08CS6 CHOYP_ISCW_ISCW015652.1.1 m.58247 sp MOXD2_DANRE 32.381 105 68 2 55 159 45 146 1.48E-10 61.6 MOXD2_DANRE reviewed DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-) moxd2 moxd1l si:ch211-203k16.5 Danio rerio (Zebrafish) (Brachydanio rerio) 572 0 GO:0005507; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q0KHY3 CHOYP_LOC574757.9.9 m.66386 sp MESH_DROME 26.465 1058 612 41 23 973 181 1179 1.48E-70 263 MESH_DROME reviewed Protein mesh mesh CG31004 Drosophila melanogaster (Fruit fly) 1454 cell-matrix adhesion [GO:0007160]; multicellular organism development [GO:0007275]; smooth septate junction assembly [GO:0090528] GO:0005920; GO:0007160; GO:0007275; GO:0016021; GO:0016327; GO:0090528 0 0 0 PF03782;PF06119;PF00084;PF00094; Q0ZM14 CHOYP_FAT.2.2 m.24395 sp PCD15_CHICK 29.61 385 213 18 40 399 18 369 1.48E-22 105 PCD15_CHICK reviewed Protocadherin-15 Pcdh15 Gallus gallus (Chicken) 1899 actin filament bundle assembly [GO:0051017]; adult walking behavior [GO:0007628]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in equilibrioception [GO:0050973]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of an epithelium [GO:0002009]; multicellular organism growth [GO:0035264]; nonmotile primary cilium assembly [GO:0035058]; righting reflex [GO:0060013]; startle response [GO:0001964]; visual perception [GO:0007601] GO:0001750; GO:0001964; GO:0002009; GO:0005509; GO:0005737; GO:0005886; GO:0007156; GO:0007601; GO:0007628; GO:0016021; GO:0032420; GO:0035058; GO:0035264; GO:0050910; GO:0050973; GO:0051017; GO:0060013; GO:0060088 0 0 0 PF00028; Q13416 CHOYP_LOC100371654.1.1 m.14187 sp ORC2_HUMAN 44.214 579 279 10 16 564 10 574 1.48E-154 457 ORC2_HUMAN reviewed Origin recognition complex subunit 2 ORC2 ORC2L Homo sapiens (Human) 577 DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122] GO:0000082; GO:0000122; GO:0000784; GO:0000792; GO:0000808; GO:0000939; GO:0003688; GO:0005634; GO:0005654; GO:0005664; GO:0005813; GO:0006260; GO:0006270; GO:0016020 0 0 0 PF04084; Q1RK13 CHOYP_LOC100637968.12.12 m.65659 sp Y220_RICBR 48.837 86 44 0 289 374 519 604 1.48E-13 75.9 Y220_RICBR reviewed Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) 826 0 0 0 0 0 PF00023;PF12796; Q24400 CHOYP_MLP2.4.4 m.62619 sp MLP2_DROME 42.067 416 213 9 12 424 2 392 1.48E-89 283 MLP2_DROME reviewed Muscle LIM protein Mlp84B Mlp84B LIM3 CG10699 Drosophila melanogaster (Fruit fly) 495 muscle organ development [GO:0007517]; muscle tissue development [GO:0060537]; regulation of establishment of planar polarity [GO:0090175]; sarcomere organization [GO:0045214] GO:0005634; GO:0007517; GO:0008270; GO:0008307; GO:0030018; GO:0045214; GO:0060537; GO:0090175 0 0 0 PF00412; Q26636 CHOYP_LOC100197138.1.1 m.52179 sp CATL_SARPE 46.774 124 59 3 104 220 37 160 1.48E-27 110 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q2TBV5 CHOYP_BRAFLDRAFT_282199.1.1 m.13541 sp TF2H2_BOVIN 61.398 329 125 1 1 327 57 385 1.48E-158 452 TF2H2_BOVIN reviewed General transcription factor IIH subunit 2 (General transcription factor IIH polypeptide 2) GTF2H2 Bos taurus (Bovine) 395 "nucleotide-excision repair [GO:0006289]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000439; GO:0005675; GO:0006289; GO:0006355; GO:0006366; GO:0006468; GO:0008270 0 0 0 PF07975;PF04056; Q32LJ2 CHOYP_LOC101072591.1.1 m.1861 sp ARFRP_BOVIN 65.347 202 69 1 1 202 1 201 1.48E-99 289 ARFRP_BOVIN reviewed ADP-ribosylation factor-related protein 1 (ARF-related protein 1) ARFRP1 Bos taurus (Bovine) 201 "gastrulation [GO:0007369]; Golgi to plasma membrane protein transport [GO:0043001]; protein localization to Golgi apparatus [GO:0034067]; retrograde transport, endosome to Golgi [GO:0042147]; small GTPase mediated signal transduction [GO:0007264]" GO:0005525; GO:0005802; GO:0005829; GO:0007264; GO:0007369; GO:0016020; GO:0034067; GO:0042147; GO:0043001 0 0 0 PF00025; Q3ZBD7 CHOYP_LOC100366799.2.2 m.41661 sp G6PI_BOVIN 55.696 158 70 0 7 164 2 159 1.48E-56 189 G6PI_BOVIN reviewed Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) GPI Bos taurus (Bovine) 557 angiogenesis [GO:0001525]; erythrocyte homeostasis [GO:0034101]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; glycolytic process [GO:0006096]; in utero embryonic development [GO:0001701]; mesoderm formation [GO:0001707] GO:0001525; GO:0001701; GO:0001707; GO:0004347; GO:0005615; GO:0005654; GO:0005737; GO:0006094; GO:0006096; GO:0034101; GO:0042593; GO:0043209; GO:0060170; GO:0070062 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. 0 0 PF00342; Q460N5 CHOYP_PARP14.5.22 m.24660 sp PAR14_HUMAN 31.872 935 588 22 3 931 909 1800 1.48E-124 418 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q49B93 CHOYP_BRAFLDRAFT_268046.2.3 m.43260 sp SC5AC_MOUSE 43.894 606 303 8 15 618 4 574 1.48E-175 516 SC5AC_MOUSE reviewed Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) Slc5a12 Smct2 Mus musculus (Mouse) 619 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015129; GO:0015293; GO:0015355; GO:0016324; GO:0070062 0 0 0 PF00474; Q54NW7 CHOYP_TVAG_411330.1.1 m.43429 sp VAM7A_DICDI 27.473 91 66 0 502 592 123 213 1.48E-07 55.8 VAM7A_DICDI reviewed Vesicle-associated membrane protein 7A vamp7A vamp7 DDB_G0284951 Dictyostelium discoideum (Slime mold) 216 endosome to lysosome transport [GO:0008333]; exocytosis [GO:0006887]; protein transport [GO:0015031]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] GO:0000149; GO:0005484; GO:0005765; GO:0005768; GO:0005789; GO:0005794; GO:0006887; GO:0006906; GO:0008333; GO:0015031; GO:0016021; GO:0016192; GO:0030658; GO:0030666; GO:0030670; GO:0031201; GO:0031902; GO:0045335 0 0 0 PF13774;PF00957; Q5BIM1 CHOYP_LOC100374741.58.83 m.53290 sp TRI45_BOVIN 24 225 149 6 4 219 127 338 1.48E-07 55.8 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5BJJ5 CHOYP_HDHD2.1.1 m.14528 sp HDHD2_DANRE 65.174 201 69 1 2 202 56 255 1.48E-94 279 HDHD2_DANRE reviewed Haloacid dehalogenase-like hydrolase domain-containing protein 2 hdhd2 zgc:110332 Danio rerio (Zebrafish) (Brachydanio rerio) 262 dephosphorylation [GO:0016311] GO:0016311; GO:0016791; GO:0046872 0 0 0 PF13344; Q5G266 CHOYP_LOC100633732.2.3 m.39657 sp NETR_TRAPH 46.769 325 158 5 29 343 280 599 1.48E-86 297 NETR_TRAPH reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Trachypithecus phayrei (Phayre's leaf monkey) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5H8C4 CHOYP_BRAFLDRAFT_226506.2.3 m.52407 sp VP13A_MOUSE 34.276 919 531 20 1 876 117 1005 1.48E-153 503 VP13A_MOUSE reviewed Vacuolar protein sorting-associated protein 13A (Chorea-acanthocytosis protein homolog) (Chorein) Vps13a Chac Kiaa0986 Mus musculus (Mouse) 3166 locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; social behavior [GO:0035176] GO:0006623; GO:0007399; GO:0007626; GO:0019898; GO:0031045; GO:0035176; GO:0045053 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q5RC94 CHOYP_LOC100372432.3.3 m.23301 sp NBR1_PONAB 30.482 456 232 16 145 596 154 528 1.48E-43 174 NBR1_PONAB reviewed Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) NBR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 894 macroautophagy [GO:0016236]; protein oligomerization [GO:0051259] GO:0005764; GO:0005770; GO:0005776; GO:0005829; GO:0008270; GO:0016236; GO:0031410; GO:0031430; GO:0043130; GO:0051259 0 0 cd14947; PF16158;PF00564;PF00569; Q5RCS8 CHOYP_VATD.1.2 m.38603 sp VATD_PONAB 76.419 229 54 0 3 231 18 246 1.48E-125 358 VATD_PONAB reviewed V-type proton ATPase subunit D (V-ATPase subunit D) (Vacuolar proton pump subunit D) ATP6V1D Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 247 cilium assembly [GO:0042384]; protein localization to cilium [GO:0061512]; proton transport [GO:0015992] GO:0005765; GO:0005813; GO:0005929; GO:0015992; GO:0033176; GO:0042384; GO:0042626; GO:0061512; GO:0070062 0 0 0 PF01813; Q5RGJ8 CHOYP_BRAFLDRAFT_125953.1.1 m.62456 sp GNPTA_DANRE 36.418 335 191 9 1 320 438 765 1.48E-60 212 GNPTA_DANRE reviewed N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein gnptab) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] gnptab gnpta si:ch211-234f20.3 zgc:122985 Danio rerio (Zebrafish) (Brachydanio rerio) 1219 carbohydrate phosphorylation [GO:0046835]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256] GO:0000139; GO:0002063; GO:0003976; GO:0005509; GO:0005794; GO:0007040; GO:0016021; GO:0016256; GO:0046835; GO:0048701; GO:0048703; GO:0051216 0 0 0 PF06464;PF00066;PF17101;PF11380;PF17102;PF17103; Q5XI29 CHOYP_LOC100372147.1.2 m.19103 sp CPSF7_RAT 42.14 458 181 17 15 449 3 399 1.48E-80 262 CPSF7_RAT reviewed Cleavage and polyadenylation specificity factor subunit 7 Cpsf7 Rattus norvegicus (Rat) 462 mRNA processing [GO:0006397]; protein tetramerization [GO:0051262] GO:0000166; GO:0005634; GO:0005849; GO:0006397; GO:0016020; GO:0044822; GO:0051262 0 0 0 PF00076; Q5ZJ24 CHOYP_BRAFLDRAFT_85158.1.1 m.54841 sp FOPNL_CHICK 58.974 78 32 0 11 88 56 133 1.48E-23 92 FOPNL_CHICK reviewed LisH domain-containing protein FOPNL (FGFR1OP N-terminal-like protein) FOPNL RCJMB04_21j4 Gallus gallus (Chicken) 175 cilium assembly [GO:0042384]; microtubule anchoring [GO:0034453] GO:0031514; GO:0034451; GO:0034453; GO:0036064; GO:0042384 0 0 0 PF09398; Q6A070 CHOYP_FAM179B.2.2 m.37590 sp F179B_MOUSE 32.924 978 507 20 743 1674 895 1769 1.48E-128 446 F179B_MOUSE reviewed Protein FAM179B Fam179b Kiaa0423 Mus musculus (Mouse) 1776 0 0 0 0 0 0 Q6DFC0 CHOYP_LOC100372696.1.2 m.15931 sp S41A2_XENLA 56.388 454 194 3 78 529 110 561 1.48E-177 514 S41A2_XENLA reviewed Solute carrier family 41 member 2 slc41a2 Xenopus laevis (African clawed frog) 561 0 GO:0005886; GO:0008324; GO:0016021 0 0 0 PF01769; Q6DGX3 CHOYP_ANR54.1.2 m.14018 sp ANR54_DANRE 46.411 209 112 0 84 292 100 308 1.48E-58 192 ANR54_DANRE reviewed Ankyrin repeat domain-containing protein 54 ankrd54 zgc:110569 zgc:92735 Danio rerio (Zebrafish) (Brachydanio rerio) 315 0 GO:0005634; GO:0005737; GO:0030496 0 0 0 PF00023;PF12796; Q6IFT6 CHOYP_BRAFLDRAFT_126668.1.2 m.48032 sp ANO7_RAT 30.7 671 340 16 301 894 212 834 1.48E-78 278 ANO7_RAT reviewed Anoctamin-7 (New gene expressed in prostate homolog) (Transmembrane protein 16G) Ano7 Ngep Tmem16g Rattus norvegicus (Rat) 860 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589] GO:0005229; GO:0005622; GO:0005634; GO:0005783; GO:0005886; GO:0016021; GO:0017128; GO:0061589; GO:0061590; GO:0061591 0 0 0 PF16178;PF04547; Q6PFY8 CHOYP_LOC100213744.15.19 m.48250 sp TRI45_MOUSE 28.235 255 161 7 5 246 127 372 1.48E-12 73.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PFY8 CHOYP_NEMVEDRAFT_V1G198897.1.6 m.2207 sp TRI45_MOUSE 21.69 355 229 10 9 332 29 365 1.48E-12 72.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7M4 CHOYP_CP2F5.1.1 m.15117 sp C15A1_DIPPU 41.611 149 85 1 1 149 339 485 1.48E-32 123 C15A1_DIPPU reviewed Methyl farnesoate epoxidase (EC 1.14.13.202) (Cytochrome P450 CYP15A1) CYP15A1 Diploptera punctata (Pacific beetle cockroach) 493 juvenile hormone biosynthetic process [GO:0006718] GO:0005506; GO:0006718; GO:0016709; GO:0020037 0 0 0 PF00067; Q6RHW4 CHOYP_LOC100703179.1.1 m.43227 sp HYAL1_PIG 33.911 404 243 4 65 446 30 431 1.48E-75 245 HYAL1_PIG reviewed Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) HYAL1 Sus scrofa (Pig) 435 carbohydrate metabolic process [GO:0005975]; cartilage development [GO:0051216]; cellular response to interleukin-1 [GO:0071347]; cellular response to pH [GO:0071467]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to UV-B [GO:0071493]; hyaluronan biosynthetic process [GO:0030213]; hyaluronan catabolic process [GO:0030214]; hyaluronan metabolic process [GO:0030212]; inflammatory response [GO:0006954]; negative regulation of cell growth [GO:0030308]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of growth [GO:0045927]; positive regulation of hyaluranon cable assembly [GO:1900106]; response to antibiotic [GO:0046677]; response to reactive oxygen species [GO:0000302]; response to virus [GO:0009615] GO:0000302; GO:0004415; GO:0005615; GO:0005737; GO:0005764; GO:0005975; GO:0006954; GO:0008134; GO:0009615; GO:0010634; GO:0030212; GO:0030213; GO:0030214; GO:0030307; GO:0030308; GO:0031410; GO:0036117; GO:0036120; GO:0045766; GO:0045785; GO:0045927; GO:0046677; GO:0050501; GO:0050679; GO:0051216; GO:0071347; GO:0071467; GO:0071493; GO:1900106 0 0 0 PF01630; Q7RTY7 CHOYP_BRAFLDRAFT_123741.1.1 m.31088 sp OVCH1_HUMAN 34.402 468 269 13 470 927 372 811 1.48E-66 246 OVCH1_HUMAN reviewed Ovochymase-1 (EC 3.4.21.-) OVCH1 Homo sapiens (Human) 1134 0 GO:0004252; GO:0005576; GO:0046872 0 0 cd00190; PF00431;PF00089; Q7SZE5 CHOYP_SC23A.1.1 m.16635 sp SC23A_DANRE 81.545 233 38 1 1 233 538 765 1.48E-138 409 SC23A_DANRE reviewed Protein transport protein Sec23A (SEC23-related protein A) sec23a Danio rerio (Zebrafish) (Brachydanio rerio) 765 cartilage development [GO:0051216]; embryonic neurocranium morphogenesis [GO:0048702]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; pectoral fin morphogenesis [GO:0035138] GO:0000139; GO:0006886; GO:0006888; GO:0008270; GO:0030127; GO:0030868; GO:0035138; GO:0048702; GO:0051216 0 0 0 PF00626;PF08033;PF04815;PF04811;PF04810; Q7TN88 CHOYP_LOC100378512.5.6 m.52594 sp PK1L2_MOUSE 27.52 625 403 13 826 1442 1814 2396 1.48E-63 244 PK1L2_MOUSE reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) 2461 detection of mechanical stimulus [GO:0050982] GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q86UB2 CHOYP_BIVM.2.3 m.48212 sp BIVM_HUMAN 55.401 287 120 3 281 561 139 423 1.48E-110 345 BIVM_HUMAN reviewed Basic immunoglobulin-like variable motif-containing protein BIVM Homo sapiens (Human) 503 0 GO:0005615; GO:0005634; GO:0005737 0 0 0 0 Q8BGF9 CHOYP_LOC100881208.1.1 m.18816 sp S2544_MOUSE 28.571 322 201 9 15 322 8 314 1.48E-29 117 S2544_MOUSE reviewed Solute carrier family 25 member 44 Slc25a44 Mus musculus (Mouse) 314 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q8CFE4 CHOYP_LOC661144.1.1 m.44320 sp SCYL2_MOUSE 27.645 586 415 5 16 594 25 608 1.48E-82 285 SCYL2_MOUSE reviewed SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa) Scyl2 Cvak104 D10Ertd802e Mus musculus (Mouse) 930 endosome to lysosome transport [GO:0008333]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of clathrin-mediated endocytosis [GO:2000370]; positive regulation of receptor internalization [GO:0002092]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286] GO:0002092; GO:0004672; GO:0005102; GO:0005524; GO:0005794; GO:0008333; GO:0010008; GO:0030136; GO:0048471; GO:0090090; GO:2000286; GO:2000370 0 0 0 PF00069; Q8HY87 CHOYP_RNZ2.1.1 m.17322 sp RNZ2_MACFA 39.706 68 41 0 214 281 305 372 1.48E-10 65.1 RNZ2_MACFA reviewed Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) ELAC2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 826 "mitochondrial tRNA 3'-trailer cleavage, endonucleolytic [GO:0072684]" GO:0004519; GO:0005634; GO:0005739; GO:0046872; GO:0072684 0 0 0 PF12706;PF13691; Q8N4P6 CHOYP_LOC100367394.2.2 m.50040 sp LRC71_HUMAN 36.641 524 292 14 82 592 49 545 1.48E-88 288 LRC71_HUMAN reviewed Leucine-rich repeat-containing protein 71 LRRC71 C1orf92 Homo sapiens (Human) 559 0 0 0 0 0 PF13516; Q8N5R6 CHOYP_BRAFLDRAFT_118966.1.1 m.62947 sp CCD33_HUMAN 32.913 635 346 16 10 632 20 586 1.48E-91 317 CCD33_HUMAN reviewed Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61) CCDC33 Homo sapiens (Human) 958 0 0 0 0 0 PF00168; Q8NFD2 CHOYP_TVAG_168010.44.45 m.64630 sp ANKK1_HUMAN 40.288 139 83 0 2 140 387 525 1.48E-25 104 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8TE60 CHOYP_ATS10.1.1 m.43473 sp ATS18_HUMAN 26.246 301 196 9 358 656 302 578 1.48E-22 108 ATS18_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) ADAMTS18 ADAMTS21 Homo sapiens (Human) 1221 eye development [GO:0001654]; negative regulation of platelet aggregation [GO:0090331] GO:0001654; GO:0004222; GO:0005578; GO:0008270; GO:0090331 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q8VHW4 CHOYP_CCG7.1.1 m.55887 sp CCG5_MOUSE 26.087 253 147 9 3 253 4 218 1.48E-17 83.2 CCG5_MOUSE reviewed Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) Cacng5 Mus musculus (Mouse) 275 calcium ion transmembrane transport [GO:0070588]; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311]; transmission of nerve impulse [GO:0019226] GO:0005245; GO:0014069; GO:0016247; GO:0019226; GO:0030054; GO:0032281; GO:0045211; GO:0070588; GO:2000311 0 0 0 PF00822; Q8WXG9 CHOYP_GPR98.5.5 m.49363 sp GPR98_HUMAN 37.305 898 542 12 10 895 1965 2853 1.48E-172 559 GPR98_HUMAN reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 Homo sapiens (Human) 6306 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; maintenance of organ identity [GO:0048496]; nervous system development [GO:0007399]; neurological system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; single organismal cell-cell adhesion [GO:0016337]; visual perception [GO:0007601] GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0007166; GO:0007186; GO:0007399; GO:0007601; GO:0007605; GO:0009986; GO:0016020; GO:0016021; GO:0016337; GO:0032420; GO:0043235; GO:0045202; GO:0045494; GO:0048496; GO:0050877; GO:0050953; GO:0070062 0 0 0 PF00002;PF03160;PF03736; Q90744 CHOYP_TRIADDRAFT_23253.1.1 m.5962 sp NAGAB_CHICK 62.5 176 65 1 17 191 1 176 1.48E-82 254 NAGAB_CHICK reviewed Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Gallus gallus (Chicken) 405 carbohydrate metabolic process [GO:0005975]; glycoside catabolic process [GO:0016139] GO:0004557; GO:0005737; GO:0005764; GO:0005975; GO:0008456; GO:0016139 0 0 cd14792; PF16499; Q95NI4 CHOYP_DGRI_GH12737.1.1 m.28681 sp CALM_HALOK 58.503 147 56 1 16 162 6 147 1.48E-53 170 CALM_HALOK reviewed Calmodulin (CaM) 0 Halichondria okadai (Marine sponge) (Reniera okadai) 149 0 GO:0005509 0 0 0 PF13499; Q95NI4 CHOYP_LOC100162151.1.1 m.30584 sp CALM_HALOK 58.503 147 56 1 16 162 6 147 1.48E-53 170 CALM_HALOK reviewed Calmodulin (CaM) 0 Halichondria okadai (Marine sponge) (Reniera okadai) 149 0 GO:0005509 0 0 0 PF13499; Q96II8 CHOYP_LRCH2.1.2 m.45074 sp LRCH3_HUMAN 54.661 236 106 1 12 247 44 278 1.48E-73 258 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q9CQ20 CHOYP_M1I1L.1.1 m.4329 sp M1IP1_MOUSE 31.325 166 81 5 17 151 12 175 1.48E-15 73.2 M1IP1_MOUSE reviewed Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499 homolog) (Spot 14-related protein) (S14R) (Spot 14-R) Mid1ip1 Mig12 Mus musculus (Mouse) 182 lipid metabolic process [GO:0006629]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of fatty acid biosynthetic process [GO:0045723]; positive regulation of ligase activity [GO:0051351]; protein polymerization [GO:0051258]; regulation of lipid biosynthetic process [GO:0046890] GO:0005634; GO:0005737; GO:0005829; GO:0005874; GO:0006629; GO:0007026; GO:0008022; GO:0015630; GO:0045723; GO:0046890; GO:0051258; GO:0051351 0 0 0 PF07084; Q9D5V6 CHOYP_LOC574928.2.2 m.64166 sp SYAP1_MOUSE 47.588 311 112 8 81 371 65 344 1.48E-77 246 SYAP1_MOUSE reviewed Synapse-associated protein 1 Syap1 Mus musculus (Mouse) 365 0 GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0070062 0 0 0 PF03909; Q9NWK9 CHOYP_RL4.1.6 m.1148 sp BCD1_HUMAN 50.847 118 57 1 6 122 218 335 1.48E-33 124 BCD1_HUMAN reviewed Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6) ZNHIT6 BCD1 C1orf181 Homo sapiens (Human) 470 box C/D snoRNP assembly [GO:0000492]; protein oligomerization [GO:0051259]; ribosome biogenesis [GO:0042254]; snoRNA localization [GO:0048254] GO:0000492; GO:0001094; GO:0019899; GO:0042254; GO:0042802; GO:0046872; GO:0048254; GO:0051117; GO:0051259; GO:0070062; GO:0070761 0 0 0 PF04438; Q9ULJ7 CHOYP_TVAG_397280.1.1 m.55527 sp ANR50_HUMAN 33.52 358 197 14 964 1306 548 879 1.48E-31 138 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9UPV9 CHOYP_TRAK1.2.2 m.67020 sp TRAK1_HUMAN 55.128 156 57 3 20 165 96 248 1.48E-40 148 TRAK1_HUMAN reviewed Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) TRAK1 KIAA1042 OIP106 Homo sapiens (Human) 953 endosome to lysosome transport [GO:0008333]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0005634; GO:0005737; GO:0005739; GO:0005769; GO:0006357; GO:0006493; GO:0006605; GO:0008333 0 0 0 PF04849;PF12448; Q9VCA2 CHOYP_ORCT.4.6 m.55573 sp ORCT_DROME 35.409 257 146 4 3 248 274 521 1.48E-42 155 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9VEX9 CHOYP_LOC100633059.1.1 m.20100 sp SAP18_DROME 62.667 150 55 1 11 160 1 149 1.48E-65 199 SAP18_DROME reviewed Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (Bicoid-interacting protein 1) (dSAP18) Bin1 SAP18 CG6046 Drosophila melanogaster (Fruit fly) 150 "chromatin silencing [GO:0006342]; mRNA splicing, via spliceosome [GO:0000398]; multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0000398; GO:0003714; GO:0005737; GO:0006342; GO:0006351; GO:0007275; GO:0008134; GO:0016580; GO:0045892; GO:0071011; GO:0071013 0 0 0 PF06487; A4IF63 CHOYP_BRAFLDRAFT_85706.4.5 m.54191 sp TRIM2_BOVIN 24.257 202 147 2 376 573 545 744 1.49E-10 67.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4QNN3 CHOYP_BRAFLDRAFT_81334.1.1 m.4862 sp UBP30_XENTR 36.345 476 234 13 44 488 67 504 1.49E-76 252 UBP30_XENTR reviewed Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) usp30 TEgg099b09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 519 mitochondrial fusion [GO:0008053]; mitophagy [GO:0000422]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000422; GO:0004197; GO:0004843; GO:0005739; GO:0005741; GO:0006511; GO:0008053; GO:0016021; GO:0016579; GO:0035871; GO:0044313 0 0 0 PF00443; B0BLT0 CHOYP_LOC100374254.1.1 m.22199 sp ZN593_XENTR 55.645 124 53 1 28 149 1 124 1.49E-42 140 ZN593_XENTR reviewed Zinc finger protein 593 znf593 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 0 GO:0003676; GO:0008270 0 0 0 PF12171; B1H2P5 CHOYP_CE120.2.2 m.48974 sp CE120_XENTR 54.148 229 83 4 5 232 6 213 1.49E-71 237 CE120_XENTR reviewed Centrosomal protein of 120 kDa (Cep120) (Coiled-coil domain-containing protein 100) cep120 ccdc100 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 882 0 GO:0005737; GO:0005815 0 0 0 PF00168;PF12416; B3EWZ3 CHOYP_HMCN1.24.44 m.44272 sp CADN_ACRMI 42.953 149 68 8 1 149 416 547 1.49E-22 99.8 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; D3YXG0 CHOYP_BRAFLDRAFT_118068.1.1 m.27573 sp HMCN1_MOUSE 40.351 171 82 8 491 658 4638 4791 1.49E-27 123 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D9IQ16 CHOYP_LOC100180758.2.2 m.39713 sp GXN_ACRMI 27.609 297 161 10 26 307 53 310 1.49E-15 81.6 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 O16797 CHOYP_LOC660560.4.4 m.54544 sp RL3_DROME 75.799 219 53 0 1 219 181 399 1.49E-120 351 RL3_DROME reviewed 60S ribosomal protein L3 RpL3 CG4863 Drosophila melanogaster (Fruit fly) 416 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0051297; GO:0051298 0 0 0 PF00297; O60290 CHOYP_NEMVEDRAFT_V1G217896.1.1 m.12834 sp ZN862_HUMAN 24.036 337 224 10 28 354 781 1095 1.49E-10 67.4 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; O75369 CHOYP_PHUM_PHUM076810.1.1 m.24070 sp FLNB_HUMAN 24.138 1711 1149 50 95 1693 608 2281 1.49E-125 442 FLNB_HUMAN reviewed Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) FLNB FLN1L FLN3 TABP TAP Homo sapiens (Human) 2602 actin cytoskeleton organization [GO:0030036]; cytoskeletal anchoring at plasma membrane [GO:0007016]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519] GO:0001725; GO:0003334; GO:0003382; GO:0003779; GO:0005737; GO:0005829; GO:0005886; GO:0005903; GO:0005913; GO:0005925; GO:0005938; GO:0007016; GO:0007165; GO:0007519; GO:0015629; GO:0016021; GO:0030018; GO:0030036; GO:0031012; GO:0042802; GO:0044822; GO:0070062; GO:0098641 0 0 0 PF00307;PF00630; O86034 CHOYP_BDHA.1.1 m.22916 sp BDHA_RHIME 40.957 188 109 1 3 188 3 190 1.49E-38 136 BDHA_RHIME reviewed D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) bdhA RB1136 SMb21010 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) 258 0 GO:0003858 0 0 0 0 O88450 CHOYP_BRAFLDRAFT_75725.1.1 m.9603 sp DEAF1_RAT 43.288 365 175 11 66 406 145 501 1.49E-68 232 DEAF1_RAT reviewed Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) Deaf1 Spn Rattus norvegicus (Rat) 565 "embryonic skeletal system development [GO:0048706]; neural tube closure [GO:0001843]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of multicellular organismal development [GO:2000026]; transcription, DNA-templated [GO:0006351]" GO:0001843; GO:0003677; GO:0003700; GO:0005576; GO:0005634; GO:0006351; GO:0033599; GO:0045944; GO:0046872; GO:0048706; GO:2000026 0 0 0 PF01342;PF01753; P00184 CHOYP_LOC100371043.4.5 m.34262 sp CP1A1_MOUSE 25.688 109 80 1 10 118 178 285 1.49E-06 49.3 CP1A1_MOUSE reviewed Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450-P1) Cyp1a1 Cyp1a-1 Mus musculus (Mouse) 524 9-cis-retinoic acid biosynthetic process [GO:0042904]; aging [GO:0007568]; amine metabolic process [GO:0009308]; camera-type eye development [GO:0043010]; cell proliferation [GO:0008283]; cellular response to organic cyclic compound [GO:0071407]; coumarin metabolic process [GO:0009804]; digestive tract development [GO:0048565]; drug metabolic process [GO:0017144]; embryo development ending in birth or egg hatching [GO:0009792]; flavonoid metabolic process [GO:0009812]; hepatocyte differentiation [GO:0070365]; heterocycle metabolic process [GO:0046483]; hydrogen peroxide biosynthetic process [GO:0050665]; insecticide metabolic process [GO:0017143]; maternal process involved in parturition [GO:0060137]; oxidation-reduction process [GO:0055114]; porphyrin-containing compound metabolic process [GO:0006778]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; response to antibiotic [GO:0046677]; response to arsenic-containing substance [GO:0046685]; response to drug [GO:0042493]; response to food [GO:0032094]; response to herbicide [GO:0009635]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to iron(III) ion [GO:0010041]; response to lipopolysaccharide [GO:0032496]; response to nematode [GO:0009624]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to vitamin A [GO:0033189]; response to wounding [GO:0009611]; toxin metabolic process [GO:0009404] GO:0001666; GO:0004497; GO:0005506; GO:0005739; GO:0005789; GO:0006778; GO:0007568; GO:0008283; GO:0008395; GO:0009308; GO:0009404; GO:0009611; GO:0009615; GO:0009624; GO:0009635; GO:0009636; GO:0009792; GO:0009804; GO:0009812; GO:0010041; GO:0016491; GO:0016679; GO:0016711; GO:0016712; GO:0017143; GO:0017144; GO:0020037; GO:0031090; GO:0032094; GO:0032451; GO:0032496; GO:0033189; GO:0035902; GO:0042493; GO:0042904; GO:0043010; GO:0043231; GO:0046483; GO:0046677; GO:0046685; GO:0048565; GO:0050665; GO:0055093; GO:0055114; GO:0060137; GO:0070330; GO:0070365; GO:0070576; GO:0071407; GO:1900087 0 0 0 PF00067; P11047 CHOYP_LAMC1.1.1 m.36098 sp LAMC1_HUMAN 52.617 363 159 5 23 379 38 393 1.49E-123 393 LAMC1_HUMAN reviewed Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma) LAMC1 LAMB2 Homo sapiens (Human) 1609 cell adhesion [GO:0007155]; cell migration [GO:0016477]; endoderm development [GO:0007492]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; hemidesmosome assembly [GO:0031581]; positive regulation of epithelial cell proliferation [GO:0050679]; protein complex assembly [GO:0006461]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0005201; GO:0005576; GO:0005604; GO:0005606; GO:0005615; GO:0006461; GO:0007155; GO:0007492; GO:0016477; GO:0022617; GO:0030198; GO:0031012; GO:0031581; GO:0034446; GO:0043259; GO:0043260; GO:0050679; GO:0070062 0 0 0 PF00052;PF00053;PF00055; P16157 CHOYP_AFUA_1G01020.34.50 m.43182 sp ANK1_HUMAN 32.277 694 415 7 54 696 82 771 1.49E-85 298 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17133 CHOYP_AAEL_AAEL015585.1.3 m.3838 sp RU17_DROME 65.605 157 54 0 1 157 1 157 1.49E-60 196 RU17_DROME reviewed U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) snRNP-U1-70K snRNP27D snRNP70K CG8749 Drosophila melanogaster (Fruit fly) 448 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; neurogenesis [GO:0022008]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]" GO:0000166; GO:0000243; GO:0000381; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005681; GO:0005685; GO:0007052; GO:0016607; GO:0022008; GO:0030619; GO:0043484; GO:0048025; GO:0071004; GO:0071011; GO:0071013 0 0 0 PF00076;PF12220; P17133 CHOYP_AAEL_AAEL015585.2.3 m.30194 sp RU17_DROME 65.605 157 54 0 1 157 1 157 1.49E-60 196 RU17_DROME reviewed U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) snRNP-U1-70K snRNP27D snRNP70K CG8749 Drosophila melanogaster (Fruit fly) 448 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; neurogenesis [GO:0022008]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]" GO:0000166; GO:0000243; GO:0000381; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005681; GO:0005685; GO:0007052; GO:0016607; GO:0022008; GO:0030619; GO:0043484; GO:0048025; GO:0071004; GO:0071011; GO:0071013 0 0 0 PF00076;PF12220; P17666 CHOYP_CP2CE.1.1 m.34630 sp CP2CE_RABIT 41.892 444 249 7 16 453 20 460 1.49E-111 341 CP2CE_RABIT reviewed Cytochrome P450 2C14 (EC 1.14.14.1) (CYPIIC14) (Cytochrome P450 PHP3) CYP2C14 Oryctolagus cuniculus (Rabbit) 490 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P18433 CHOYP_LOC100638857.1.1 m.56861 sp PTPRA_HUMAN 30.702 114 78 1 53 166 676 788 1.49E-15 76.6 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P18503 CHOYP_BRAFLDRAFT_67695.1.1 m.60683 sp CAS4_EPHMU 34.426 122 66 3 79 200 206 313 1.49E-08 58.2 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P29350 CHOYP_LOC101172160.1.1 m.9829 sp PTN6_HUMAN 44.884 303 149 5 353 644 244 539 1.49E-73 258 PTN6_HUMAN reviewed Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) PTPN6 HCP PTP1C Homo sapiens (Human) 595 abortive mitotic cell cycle [GO:0033277]; apoptotic process [GO:0006915]; B cell receptor signaling pathway [GO:0050853]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; G-protein coupled receptor signaling pathway [GO:0007186]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular signal transduction [GO:0035556]; leukocyte migration [GO:0050900]; megakaryocyte development [GO:0035855]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of cell proliferation [GO:0008285]; negative regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002924]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet formation [GO:0030220]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; protein dephosphorylation [GO:0006470]; regulation of B cell differentiation [GO:0045577]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell costimulation [GO:0031295] GO:0002244; GO:0002924; GO:0004725; GO:0005001; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005911; GO:0006470; GO:0006915; GO:0007186; GO:0008283; GO:0008284; GO:0008285; GO:0014068; GO:0016020; GO:0018108; GO:0019901; GO:0030154; GO:0030168; GO:0030220; GO:0031295; GO:0033277; GO:0033630; GO:0035556; GO:0035855; GO:0042105; GO:0042130; GO:0042267; GO:0043407; GO:0045577; GO:0050732; GO:0050853; GO:0050859; GO:0050860; GO:0050900; GO:0051279; GO:0060338; GO:0070062; GO:0070372; GO:0070527; GO:2000045 0 0 0 PF00017;PF00102; P30151 CHOYP_EF1B.5.7 m.44881 sp EF1B_XENLA 60.769 130 44 2 3 125 65 194 1.49E-45 150 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P48159 CHOYP_RL23.1.11 m.2901 sp RL23_DROME 92.143 140 11 0 23 162 1 140 1.49E-90 262 RL23_DROME reviewed 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) 140 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0006412; GO:0007052; GO:0017022; GO:0022008; GO:0022625; GO:0070180 0 0 0 PF00238; P49154 CHOYP_RS2.10.10 m.65639 sp RS2_URECA 85.955 178 25 0 31 208 39 216 1.49E-105 308 RS2_URECA reviewed 40S ribosomal protein S2 RPS2 Urechis caupo (Innkeeper worm) (Spoonworm) 278 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; P53567 CHOYP_LOC100073409.1.2 m.25313 sp CEBPG_HUMAN 55.319 94 42 0 23 116 50 143 1.49E-28 104 CEBPG_HUMAN reviewed CCAAT/enhancer-binding protein gamma (C/EBP gamma) CEBPG Homo sapiens (Human) 150 B cell differentiation [GO:0030183]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA repair [GO:0045739]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0001077; GO:0001889; GO:0003677; GO:0005634; GO:0005654; GO:0006357; GO:0006955; GO:0008134; GO:0016071; GO:0030183; GO:0042267; GO:0043353; GO:0043388; GO:0043433; GO:0043565; GO:0044377; GO:0045078; GO:0045739; GO:0045944; GO:0046982; GO:0051091 0 0 0 PF07716; P98187 CHOYP_BRAFLDRAFT_61250.12.14 m.53898 sp CP4F8_HUMAN 39.293 509 283 9 36 528 20 518 1.49E-122 372 CP4F8_HUMAN reviewed Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016021; GO:0018685; GO:0019825; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q07E28 CHOYP_ANK1.3.8 m.25976 sp CTTB2_NEONE 33.566 143 93 1 17 157 739 881 1.49E-13 71.2 CTTB2_NEONE reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Neofelis nebulosa (Clouded leopard) 1658 0 GO:0005938; GO:0043197 0 0 0 PF00023;PF12796;PF09727; Q14831 CHOYP_MTT.1.1 m.46410 sp GRM7_HUMAN 31.366 864 518 27 27 835 43 886 1.49E-129 418 GRM7_HUMAN reviewed Metabotropic glutamate receptor 7 (mGluR7) GRM7 GPRC1G MGLUR7 Homo sapiens (Human) 915 "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [GO:0007196]; adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; conditioned taste aversion [GO:0001661]; multicellular organismal response to stress [GO:0033555]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of glutamate secretion [GO:0014050]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; short-term memory [GO:0007614]; transmission of nerve impulse [GO:0019226]" GO:0001642; GO:0001661; GO:0005245; GO:0005246; GO:0005509; GO:0005886; GO:0005887; GO:0005938; GO:0007194; GO:0007196; GO:0007268; GO:0007605; GO:0007608; GO:0007614; GO:0008066; GO:0010855; GO:0014050; GO:0016021; GO:0016595; GO:0019226; GO:0030165; GO:0030424; GO:0030425; GO:0030534; GO:0030818; GO:0032279; GO:0033555; GO:0042734; GO:0043198; GO:0043235; GO:0045211; GO:0048786; GO:0051966; GO:0070905 0 0 0 PF00003;PF01094;PF07562; Q2QI47 CHOYP_USH2A.1.6 m.8847 sp USH2A_MOUSE 34.835 999 583 21 1 953 4217 5193 1.49E-159 523 USH2A_MOUSE reviewed Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) 5193 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042803; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF00054;PF02210;PF00055; Q4FZY0 CHOYP_EFHD2.1.1 m.22844 sp EFHD2_RAT 62.827 191 70 1 2 192 50 239 1.49E-69 214 EFHD2_RAT reviewed EF-hand domain-containing protein D2 (Swiprosin-1) Efhd2 Sws1 Rattus norvegicus (Rat) 239 0 GO:0005509; GO:0045121 0 0 0 PF13499; Q5RJI4 CHOYP_LOC100184284.2.2 m.21644 sp PKDCC_MOUSE 26.014 419 248 10 124 538 130 490 1.49E-31 133 PKDCC_MOUSE reviewed "Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)" Pkdcc Sgk493 Vlk Mus musculus (Mouse) 492 bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; limb morphogenesis [GO:0035108]; lung alveolus development [GO:0048286]; multicellular organism growth [GO:0035264]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; palate development [GO:0060021]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; protein transport [GO:0015031]; skeletal system development [GO:0001501] GO:0001501; GO:0004672; GO:0004715; GO:0005524; GO:0005576; GO:0005794; GO:0015031; GO:0018108; GO:0030154; GO:0030282; GO:0030501; GO:0032332; GO:0035108; GO:0035264; GO:0042997; GO:0048286; GO:0048566; GO:0060021 0 0 0 PF12260; Q5TYW6 CHOYP_BRAFLDRAFT_121507.2.2 m.62292 sp RSPH9_DANRE 57.037 135 57 1 1 134 1 135 1.49E-48 162 RSPH9_DANRE reviewed Radial spoke head protein 9 homolog rsph9 si:ch211-117l16.2 zgc:123211 Danio rerio (Zebrafish) (Brachydanio rerio) 277 axoneme assembly [GO:0035082]; cilium movement [GO:0003341]; cilium movement involved in cell motility [GO:0060294]; motile cilium assembly [GO:0044458] GO:0003341; GO:0005737; GO:0005930; GO:0031514; GO:0035082; GO:0044458; GO:0060294 0 0 0 PF04712; Q5ZLF0 CHOYP_F10A1.4.4 m.44752 sp F10A1_CHICK 47.733 419 149 6 11 425 9 361 1.49E-115 345 F10A1_CHICK reviewed Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) ST13 FAM10A1 RCJMB04_6h13 Gallus gallus (Chicken) 361 0 GO:0005737 0 0 0 PF13181; Q642H9 CHOYP_RS4.11.11 m.63583 sp RS4X_DANRE 78.481 158 34 0 7 164 3 160 1.49E-89 265 RS4X_DANRE reviewed "40S ribosomal protein S4, X isoform" rps4x rps4 zgc:92076 Danio rerio (Zebrafish) (Brachydanio rerio) 263 brain development [GO:0007420]; chordate embryonic development [GO:0043009]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0007420; GO:0019843; GO:0022627; GO:0043009 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q6DFV8 CHOYP_NEMVEDRAFT_V1G214844.30.34 m.57747 sp VWDE_MOUSE 23.994 646 420 32 51 662 60 668 1.49E-12 75.9 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6P1C6 CHOYP_CAOG_03463.1.1 m.16746 sp LRIG3_MOUSE 24.242 396 271 13 48 430 76 455 1.49E-15 83.2 LRIG3_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) Lrig3 Kiaa3016 Mus musculus (Mouse) 1117 otolith morphogenesis [GO:0032474] GO:0005615; GO:0005886; GO:0016021; GO:0030659; GO:0032474 0 0 0 PF07679;PF13855; Q6P360 CHOYP_RN121.1.1 m.13046 sp RN121_XENTR 65.723 318 108 1 32 348 10 327 1.49E-163 462 RN121_XENTR reviewed RING finger protein 121 rnf121 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 327 endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; neuronal action potential [GO:0019228]; protein localization to plasma membrane [GO:0072659]; regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903069]; thigmotaxis [GO:0001966] GO:0000139; GO:0001966; GO:0005789; GO:0008270; GO:0016021; GO:0019228; GO:0030433; GO:0030968; GO:0061630; GO:0072659; GO:1903069 0 0 0 0 Q6P7Y3 CHOYP_LOC100745256.1.1 m.36334 sp PR38B_DANRE 53.623 69 32 0 4 72 151 219 1.49E-17 87 PR38B_DANRE reviewed Pre-mRNA-splicing factor 38B prpf38b Danio rerio (Zebrafish) (Brachydanio rerio) 501 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0006397; GO:0008380; GO:0071011 0 0 0 PF03371; Q6P9H4 CHOYP_CNKR2.1.3 m.11724 sp CNKR3_HUMAN 44.407 295 155 3 14 307 7 293 1.49E-69 244 CNKR3_HUMAN reviewed Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) CNKSR3 MAGI1 Homo sapiens (Human) 555 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765] GO:0005737; GO:0010765; GO:0016020; GO:0033137; GO:0070373 0 0 0 PF10534;PF06663;PF00595;PF00536; Q6QLW4 CHOYP_CYC.2.5 m.40563 sp CYC_PECGU 84.404 109 17 0 118 226 1 109 1.49E-63 196 CYC_PECGU reviewed Cytochrome c 0 Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm) 109 oxidation-reduction process [GO:0055114] GO:0005758; GO:0009055; GO:0020037; GO:0046872; GO:0055114; GO:0070469 0 0 0 PF00034; Q6VEU3 CHOYP_PNO1.3.3 m.61367 sp PNO1_DANRE 74.786 234 54 2 43 271 19 252 1.49E-128 367 PNO1_DANRE reviewed RNA-binding protein PNO1 pno1 zgc:65782 Danio rerio (Zebrafish) (Brachydanio rerio) 252 0 GO:0003723; GO:0005730 0 0 0 PF00013; Q7T3I0 CHOYP_ZC4H2.1.1 m.8868 sp ZC4H2_DANRE 65.333 225 73 3 5 228 4 224 1.49E-96 283 ZC4H2_DANRE reviewed Zinc finger C4H2 domain-containing protein (Hepatocellular carcinoma-associated antigen 127 homolog) (Hepatocellular carcinoma-associated antigen 127-like) zc4h2 Danio rerio (Zebrafish) (Brachydanio rerio) 224 nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; neuron development [GO:0048666]; neuron fate specification [GO:0048665]; spinal cord motor neuron differentiation [GO:0021522] GO:0005634; GO:0005737; GO:0007399; GO:0007528; GO:0021522; GO:0030054; GO:0045211; GO:0046872; GO:0048665; GO:0048666 0 0 0 PF10146; Q801G1 CHOYP_TLR2.1.7 m.25661 sp ARHA_XENLA 48.649 148 71 1 9 156 28 170 1.49E-44 156 ARHA_XENLA reviewed Low density lipoprotein receptor adapter protein 1-A (Autosomal recessive hypercholesterolemia protein homolog alpha) (ARH alpha) (xARH alpha) (Phosphotyrosine-binding protein) (Xcat4) ldlrap1-a Xenopus laevis (African clawed frog) 309 cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897] GO:0005737; GO:0006897; GO:0008203 0 0 0 PF00640; Q80TS3 CHOYP_LOC657847.1.1 m.41153 sp AGRL3_MOUSE 34.143 782 428 19 216 947 546 1290 1.49E-140 466 AGRL3_MOUSE reviewed Adhesion G protein-coupled receptor L3 (Latrophilin-3) (Lectomedin-3) Adgrl3 Kiaa0768 Lec3 Lphn3 Mus musculus (Mouse) 1537 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007416; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q8CFG8 CHOYP_LOC581886.1.3 m.23639 sp CS1B_MOUSE 39.806 103 55 5 378 475 186 286 1.49E-09 65.9 CS1B_MOUSE reviewed Complement C1s-B subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s-B) [Cleaved into: Complement C1s-B subcomponent heavy chain; Complement C1s-B subcomponent light chain] C1sb C1s Gm5077 Mus musculus (Mouse) 688 "complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]" GO:0004252; GO:0005509; GO:0006958; GO:0042802; GO:0045087; GO:0070062; GO:0072562 0 0 cd00190; PF00431;PF00084;PF00089; Q8IV38 CHOYP_ANKY2.1.2 m.2945 sp ANKY2_HUMAN 41.538 65 38 0 176 240 320 384 1.49E-08 58.5 ANKY2_HUMAN reviewed Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 Homo sapiens (Human) 441 0 GO:0005929; GO:0046872 0 0 0 PF12796;PF01753; Q8Q0U0 CHOYP_LOC754047.2.3 m.47282 sp Y045_METMA 42.105 95 53 2 60 152 170 264 1.49E-12 67 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q91VY9 CHOYP_ZN622.1.1 m.2103 sp ZN622_MOUSE 48.438 256 111 8 150 391 228 476 1.49E-71 234 ZN622_MOUSE reviewed Zinc finger protein 622 Znf622 D15Ertd806e Zfp622 Mus musculus (Mouse) 476 intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; ribosomal large subunit biogenesis [GO:0042273] GO:0005730; GO:0005737; GO:0005794; GO:0008270; GO:0008631; GO:0022625; GO:0030687; GO:0033674; GO:0042273; GO:0043065; GO:0043410; GO:0044822; GO:0046330 0 0 0 PF12756; Q92193 CHOYP_ACT.11.27 m.37945 sp ACT_CRAVI 97.076 171 5 0 1 171 49 219 1.49E-121 346 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q95WA0 CHOYP_LOC585872.3.6 m.44427 sp RL26_LITLI 81.56 141 24 1 19 157 1 141 1.49E-80 237 RL26_LITLI reviewed 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) 144 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 0 PF00467;PF16906; Q96MM6 CHOYP_BRAFLDRAFT_242762.7.8 m.45088 sp HS12B_HUMAN 32.152 395 148 12 2 346 61 385 1.49E-50 181 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_HSPA12A.16.27 m.48207 sp HS12B_HUMAN 34.439 633 347 16 8 581 61 684 1.49E-118 369 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BQ16 CHOYP_AGAP_AGAP005942.2.3 m.5990 sp TICN3_HUMAN 48.333 60 29 1 77 134 316 375 1.49E-09 60.1 TICN3_HUMAN reviewed "Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)" SPOCK3 TICN3 UNQ409/PRO771 Homo sapiens (Human) 436 negative regulation of endopeptidase activity [GO:0010951]; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan [GO:0019800]; signal transduction [GO:0007165] GO:0005509; GO:0005539; GO:0005578; GO:0005615; GO:0007165; GO:0008191; GO:0010951; GO:0019800; GO:0031012 0 0 0 PF07648;PF10591;PF00086; Q9BX84 CHOYP_LOC587471.1.1 m.20418 sp TRPM6_HUMAN 27.58 1095 587 32 80 1039 2 1025 1.49E-107 383 TRPM6_HUMAN reviewed Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) TRPM6 CHAK2 Homo sapiens (Human) 2022 calcium ion transmembrane transport [GO:0070588]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636] GO:0004674; GO:0005262; GO:0005524; GO:0005886; GO:0009636; GO:0016021; GO:0016324; GO:0031526; GO:0046872; GO:0051262; GO:0070588 0 0 0 PF02816;PF00520;PF16519; Q9BXJ4 CHOYP_BRAFLDRAFT_69134.8.13 m.51197 sp C1QT3_HUMAN 32.787 122 79 2 53 173 118 237 1.49E-10 61.6 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9CR16 CHOYP_PPID.1.1 m.55261 sp PPID_MOUSE 58.133 375 151 2 28 402 2 370 1.49E-151 436 PPID_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Rotamase D) Ppid Mus musculus (Mouse) 370 apoptotic process [GO:0006915]; cellular response to UV-A [GO:0071492]; chaperone-mediated protein folding [GO:0061077]; lipid particle organization [GO:0034389]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein complex assembly [GO:0006461]; protein folding [GO:0006457]; protein transport [GO:0015031]; regulation of apoptotic process [GO:0042981] GO:0000122; GO:0003755; GO:0005528; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006457; GO:0006461; GO:0006915; GO:0008134; GO:0015031; GO:0030331; GO:0030544; GO:0031072; GO:0034389; GO:0042277; GO:0042981; GO:0043065; GO:0045070; GO:0050714; GO:0051879; GO:0061077; GO:0071492 0 0 0 PF00160;PF13176; Q9CYC6 CHOYP_DCP2.1.1 m.19256 sp DCP2_MOUSE 51.143 350 152 6 17 355 8 349 1.49E-109 333 DCP2_MOUSE reviewed m7GpppN-mRNA hydrolase (EC 3.6.1.62) (mRNA-decapping enzyme 2) Dcp2 Mus musculus (Mouse) 422 "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; histone mRNA catabolic process [GO:0071044]; mRNA catabolic process [GO:0006402]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" GO:0000184; GO:0000290; GO:0000932; GO:0003723; GO:0005654; GO:0006402; GO:0016442; GO:0030054; GO:0030145; GO:0043231; GO:0050072; GO:0071044 0 0 0 PF05026;PF00293; Q9CZ44 CHOYP_NSF1C.1.1 m.62502 sp NSF1C_MOUSE 48.303 383 181 7 21 400 1 369 1.49E-118 352 NSF1C_MOUSE reviewed NSFL1 cofactor p47 (p97 cofactor p47) Nsfl1c Mus musculus (Mouse) 370 Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; nuclear envelope reassembly [GO:0031468]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0005543; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005795; GO:0005829; GO:0005886; GO:0007030; GO:0031468; GO:0043130; GO:0043161; GO:0045111; GO:0061025; GO:1990730 0 0 0 PF08059;PF00789; Q9DA39 CHOYP_LFG4.1.1 m.57227 sp LFG4_MOUSE 47.525 101 53 0 7 107 138 238 1.49E-22 90.9 LFG4_MOUSE reviewed Protein lifeguard 4 (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) Tmbim4 Lfg4 Mus musculus (Mouse) 238 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; regulation of calcium-mediated signaling [GO:0050848] GO:0000139; GO:0005795; GO:0006915; GO:0016021; GO:0043066; GO:0050848 0 0 0 0 Q9H9J2 CHOYP_LOC582626.1.1 m.5567 sp RM44_HUMAN 37.024 289 178 2 48 334 41 327 1.49E-58 195 RM44_HUMAN reviewed "39S ribosomal protein L44, mitochondrial (L44mt) (MRP-L44) (EC 3.1.26.-)" MRPL44 Homo sapiens (Human) 332 "mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; production of siRNA involved in RNA interference [GO:0030422]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]" GO:0003725; GO:0004525; GO:0005634; GO:0005743; GO:0005840; GO:0030422; GO:0031053; GO:0031054; GO:0044822; GO:0070125; GO:0070126; GO:0090502 0 0 0 0 Q9NJV4 CHOYP_LOAG_05095.2.2 m.58023 sp ACT1_NAEPR 29.024 379 242 9 1918 2284 2 365 1.49E-45 173 ACT1_NAEPR reviewed Actin-1 ACT1 Naegleria pringsheimi (Amoeba) 374 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9NXG6 CHOYP_LOC575509.1.2 m.50474 sp P4HTM_HUMAN 34.495 287 172 7 5 280 177 458 1.49E-49 174 P4HTM_HUMAN reviewed Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) P4HTM PH4 Homo sapiens (Human) 502 regulation of erythrocyte differentiation [GO:0045646] GO:0005506; GO:0005509; GO:0005789; GO:0016021; GO:0016706; GO:0031418; GO:0045646 0 0 0 PF13640;PF13499; Q9QXA6 CHOYP_LOC100378220.1.1 m.52554 sp BAT1_MOUSE 51.633 490 227 3 47 533 5 487 1.49E-178 514 BAT1_MOUSE reviewed "b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" Slc7a9 Bat1 Mus musculus (Mouse) 487 L-cystine transport [GO:0015811]; neutral amino acid transport [GO:0015804] GO:0005886; GO:0005887; GO:0015175; GO:0015184; GO:0015297; GO:0015804; GO:0015811; GO:0016324; GO:0031526; GO:0042605 0 0 0 PF13520; Q9QZE7 CHOYP_TSNAX.1.1 m.63601 sp TSNAX_MOUSE 48.529 204 94 5 1 194 74 276 1.49E-61 196 TSNAX_MOUSE reviewed Translin-associated protein X (Translin-associated factor X) Tsnax Trax Mus musculus (Mouse) 290 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0003697; GO:0005634; GO:0005737; GO:0005794; GO:0007275; GO:0007283; GO:0030154; GO:0043565; GO:0044822; GO:0046872; GO:0048471 0 0 0 PF01997; Q9ULJ7 CHOYP_LOC753709.27.44 m.50617 sp ANR50_HUMAN 32.512 609 352 21 1 554 501 1105 1.49E-62 228 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9V477 CHOYP_TLR4.4.4 m.51801 sp TOLL8_DROME 37.056 197 120 2 392 584 1027 1223 1.49E-33 140 TOLL8_DROME reviewed Toll-like receptor Tollo (Toll-like receptor 8) Tollo Tl-8 Toll-8 CG6890 Drosophila melanogaster (Fruit fly) 1346 axis elongation [GO:0003401]; convergent extension [GO:0060026]; innate immune response in mucosa [GO:0002227]; peripheral nervous system neuron development [GO:0048935]; regulation of glucose metabolic process [GO:0010906]; regulation of protein glycosylation [GO:0060049]; signal transduction [GO:0007165] GO:0002227; GO:0003401; GO:0007165; GO:0010906; GO:0016021; GO:0016324; GO:0048935; GO:0060026; GO:0060049 0 0 0 PF13306;PF13855;PF01582; Q9Y484 CHOYP_WIPI4.1.1 m.3875 sp WIPI4_HUMAN 61.494 348 117 4 3 333 7 354 1.49E-161 459 WIPI4_HUMAN reviewed WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) WDR45 WDRX1 WDRXI4 WIPI4 JM5 Homo sapiens (Human) 360 autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; mitophagy [GO:0000422]; nucleophagy [GO:0044804]; protein lipidation [GO:0006497]; protein localization to pre-autophagosomal structure [GO:0034497] GO:0000045; GO:0000422; GO:0005829; GO:0006497; GO:0006914; GO:0019898; GO:0032266; GO:0034045; GO:0034497; GO:0044804; GO:0080025 0 0 0 PF00400; F6NSX9 CHOYP_ZN532.1.1 m.41540 sp Z687B_DANRE 29.545 176 100 6 642 807 565 726 1.50E-11 72.4 Z687B_DANRE reviewed Zinc finger protein 687b znf687b si:dkey-204a24.9 Danio rerio (Zebrafish) (Brachydanio rerio) 1431 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF16622; O00548 CHOYP_BRAFLDRAFT_123438.2.2 m.60657 sp DLL1_HUMAN 41.584 505 283 8 16 512 18 518 1.50E-129 399 DLL1_HUMAN reviewed Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1) DLL1 UNQ146/PRO172 Homo sapiens (Human) 723 astrocyte development [GO:0014002]; cell differentiation [GO:0030154]; cell fate determination [GO:0001709]; cerebellar molecular layer formation [GO:0021688]; cerebellar Purkinje cell layer structural organization [GO:0021693]; clathrin-mediated endocytosis [GO:0072583]; compartment pattern specification [GO:0007386]; determination of left/right symmetry [GO:0007368]; endothelial tip cell fate specification [GO:0097102]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; inner ear development [GO:0048839]; lateral inhibition [GO:0046331]; left/right axis specification [GO:0070986]; loop of Henle development [GO:0072070]; marginal zone B cell differentiation [GO:0002315]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epidermal cell differentiation [GO:0045605]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of neuron differentiation [GO:0045665]; nephron development [GO:0072006]; neuronal stem cell population maintenance [GO:0097150]; neuron fate specification [GO:0048665]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in arterial endothelial cell fate commitment [GO:0060853]; organ growth [GO:0035265]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endocytosis [GO:0045807]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of skeletal muscle tissue growth [GO:0048633]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proximal/distal pattern formation [GO:0009954]; proximal tubule development [GO:0072014]; regulation of blood pressure [GO:0008217]; regulation of cell adhesion [GO:0030155]; regulation of cell division [GO:0051302]; regulation of energy homeostasis [GO:2000505]; regulation of growth [GO:0040008]; regulation of neurogenesis [GO:0050767]; regulation of skeletal muscle tissue growth [GO:0048631]; regulation of somitogenesis [GO:0014807]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]; retina development in camera-type eye [GO:0060041]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle tissue growth [GO:0048630]; skin epidermis development [GO:0098773]; somite specification [GO:0001757]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; type B pancreatic cell development [GO:0003323] GO:0001709; GO:0001756; GO:0001757; GO:0001947; GO:0002315; GO:0003323; GO:0005112; GO:0005509; GO:0005576; GO:0005886; GO:0005887; GO:0005912; GO:0007219; GO:0007220; GO:0007368; GO:0007386; GO:0008217; GO:0008284; GO:0008285; GO:0009954; GO:0014002; GO:0014807; GO:0016324; GO:0021510; GO:0021688; GO:0021693; GO:0030097; GO:0030154; GO:0030155; GO:0030857; GO:0030957; GO:0031410; GO:0032693; GO:0034351; GO:0035265; GO:0040008; GO:0045121; GO:0045596; GO:0045605; GO:0045608; GO:0045638; GO:0045662; GO:0045665; GO:0045747; GO:0045807; GO:0045944; GO:0046331; GO:0048630; GO:0048631; GO:0048633; GO:0048665; GO:0048839; GO:0050767; GO:0051302; GO:0060041; GO:0060042; GO:0060853; GO:0070986; GO:0072006; GO:0072014; GO:0072070; GO:0072583; GO:0097102; GO:0097150; GO:0098773; GO:1900746; GO:1903672; GO:2000505 0 0 0 PF01414;PF00008;PF12661;PF07657; O61366 CHOYP_LOC100378444.2.2 m.10134 sp GPRS_DROME 32.701 211 128 4 15 211 12 222 1.50E-29 119 GPRS_DROME reviewed Serine-enriched protein gprs CG18471 Drosophila melanogaster (Fruit fly) 1302 0 0 0 0 0 PF07707;PF00651; O62640 CHOYP_LOC100647366.2.2 m.59901 sp PIAP_PIG 34.737 285 173 6 298 581 86 358 1.50E-51 184 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P00178 CHOYP_BRAFLDRAFT_61459.1.3 m.4258 sp CP2B4_RABIT 34.01 394 229 10 85 462 32 410 1.50E-62 213 CP2B4_RABIT reviewed Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1) CYP2B4 Oryctolagus cuniculus (Rabbit) 491 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P02637 CHOYP_SCP.8.12 m.57173 sp SCP_MIZYE 40.678 177 100 4 2 177 2 174 1.50E-39 135 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P04069 CHOYP_LOC100881163.2.2 m.48900 sp CBPB_ASTAS 44 300 156 6 110 406 1 291 1.50E-83 261 CBPB_ASTAS reviewed Carboxypeptidase B (EC 3.4.17.2) 0 Astacus astacus (Noble crayfish) (Astacus fluviatilis) 303 0 GO:0004181; GO:0005576; GO:0008270 0 0 0 PF00246; P04177 CHOYP_TY3H.1.1 m.26972 sp TY3H_RAT 55.932 413 169 4 1 408 86 490 1.50E-164 474 TY3H_RAT reviewed Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH) Th Rattus norvegicus (Rat) 498 "aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; catecholamine biosynthetic process [GO:0042423]; cellular response to alkaloid [GO:0071312]; cellular response to drug [GO:0035690]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to manganese ion [GO:0071287]; cellular response to nicotine [GO:0071316]; cerebral cortex development [GO:0021987]; circadian sleep/wake cycle [GO:0042745]; cognition [GO:0050890]; dopamine biosynthetic process from tyrosine [GO:0006585]; eating behavior [GO:0042755]; embryonic camera-type eye morphogenesis [GO:0048596]; epinephrine biosynthetic process [GO:0042418]; eye photoreceptor cell development [GO:0042462]; fatty acid metabolic process [GO:0006631]; glycoside metabolic process [GO:0016137]; heart development [GO:0007507]; isoquinoline alkaloid metabolic process [GO:0033076]; learning [GO:0007612]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; memory [GO:0007613]; multicellular organism aging [GO:0010259]; neurotransmitter biosynthetic process [GO:0042136]; norepinephrine biosynthetic process [GO:0042421]; phthalate metabolic process [GO:0018963]; phytoalexin metabolic process [GO:0052314]; protein homotetramerization [GO:0051289]; regulation of heart contraction [GO:0008016]; response to activity [GO:0014823]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to ether [GO:0045472]; response to growth factor [GO:0070848]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to insecticide [GO:0017085]; response to isolation stress [GO:0035900]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to metal ion [GO:0010038]; response to nicotine [GO:0035094]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; response to pyrethroid [GO:0046684]; response to salt stress [GO:0009651]; response to steroid hormone [GO:0048545]; response to water deprivation [GO:0009414]; response to zinc ion [GO:0010043]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; sphingolipid metabolic process [GO:0006665]; synaptic transmission, dopaminergic [GO:0001963]; terpene metabolic process [GO:0042214]; visual perception [GO:0007601]" GO:0001666; GO:0001963; GO:0001975; GO:0004497; GO:0004511; GO:0005634; GO:0005737; GO:0005739; GO:0005790; GO:0005829; GO:0006585; GO:0006631; GO:0006665; GO:0007507; GO:0007601; GO:0007605; GO:0007612; GO:0007613; GO:0007617; GO:0007626; GO:0008016; GO:0008021; GO:0008198; GO:0008199; GO:0009414; GO:0009416; GO:0009635; GO:0009651; GO:0009898; GO:0010038; GO:0010043; GO:0010259; GO:0014070; GO:0014823; GO:0015842; GO:0016137; GO:0016597; GO:0017085; GO:0018963; GO:0019825; GO:0019904; GO:0021987; GO:0030424; GO:0030425; GO:0030659; GO:0031667; GO:0032355; GO:0032496; GO:0033076; GO:0033162; GO:0034617; GO:0035094; GO:0035176; GO:0035240; GO:0035690; GO:0035900; GO:0035902; GO:0042136; GO:0042214; GO:0042418; GO:0042421; GO:0042423; GO:0042462; GO:0042493; GO:0042745; GO:0042755; GO:0043005; GO:0043025; GO:0043195; GO:0043204; GO:0043434; GO:0045471; GO:0045472; GO:0046684; GO:0048545; GO:0048596; GO:0050890; GO:0051289; GO:0051412; GO:0051602; GO:0052314; GO:0070848; GO:0071287; GO:0071312; GO:0071316; GO:0071333; GO:0071363 PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. 0 0 PF00351;PF12549; P0DMR5 CHOYP_MET.2.2 m.54711 sp TDPZ1_MOUSE 29.53 149 94 3 643 784 197 341 1.50E-10 67.4 TDPZ1_MOUSE reviewed TD and POZ domain-containing protein 1 (MAPP family protein 2) Tdpoz1 2cpoz56 Mapp2 Spopl1 Mus musculus (Mouse) 365 0 0 0 0 0 PF00651; P10079 CHOYP_LOC100634060.13.37 m.34463 sp FBP1_STRPU 49.741 386 194 0 288 673 248 633 1.50E-115 378 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P20693 CHOYP_PGCB.1.2 m.26468 sp FCER2_MOUSE 29.787 141 83 5 54 194 182 306 1.50E-11 68.2 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P22897 CHOYP_LOC100378295.1.4 m.3278 sp MRC1_HUMAN 31.609 1218 747 39 614 1798 220 1384 1.50E-168 557 MRC1_HUMAN reviewed Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0001618; GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0005887; GO:0006898; GO:0009986; GO:0010008; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; P24821 CHOYP_LOC100641827.1.2 m.31582 sp TENA_HUMAN 41.905 210 117 4 126 332 1980 2187 1.50E-49 181 TENA_HUMAN reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC HXB Homo sapiens (Human) 2201 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; extracellular matrix organization [GO:0030198]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to wounding [GO:0009611]; wound healing [GO:0042060] GO:0001649; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009611; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0030198; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; P35822 CHOYP_PTPRM.6.15 m.44481 sp PTPRK_MOUSE 36.25 320 167 11 1 300 990 1292 1.50E-43 162 PTPRK_MOUSE reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) Ptprk Ptpk Mus musculus (Mouse) 1457 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005911; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; P46778 CHOYP_RL21.1.4 m.19435 sp RL21_HUMAN 68.75 160 50 0 1 160 1 160 1.50E-77 230 RL21_HUMAN reviewed 60S ribosomal protein L21 RPL21 Homo sapiens (Human) 160 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01157; P46778 CHOYP_RL21.2.4 m.33603 sp RL21_HUMAN 68.75 160 50 0 1 160 1 160 1.50E-77 230 RL21_HUMAN reviewed 60S ribosomal protein L21 RPL21 Homo sapiens (Human) 160 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01157; P46778 CHOYP_RL21.3.4 m.61947 sp RL21_HUMAN 68.75 160 50 0 1 160 1 160 1.50E-77 230 RL21_HUMAN reviewed 60S ribosomal protein L21 RPL21 Homo sapiens (Human) 160 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01157; P59222 CHOYP_BRAFLDRAFT_224574.17.18 m.51009 sp SREC2_MOUSE 41.463 164 89 5 211 374 242 398 1.50E-26 114 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P62752 CHOYP_RL23A.6.6 m.63333 sp RL23A_RAT 80.952 126 24 0 76 201 31 156 1.50E-66 204 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P70389 CHOYP_LOC100161217.1.1 m.64046 sp ALS_MOUSE 24.386 529 306 20 51 551 56 518 1.50E-15 83.6 ALS_MOUSE reviewed Insulin-like growth factor-binding protein complex acid labile subunit (ALS) Igfals Albs Als Mus musculus (Mouse) 603 cell adhesion [GO:0007155] GO:0005520; GO:0005654; GO:0007155; GO:0042567; GO:0070062 0 0 0 PF13855;PF01462; P86862 CHOYP_BRAFLDRAFT_163244.3.3 m.48708 sp VKT1_ANTEL 60.345 58 23 0 159 216 2 59 1.50E-19 82 VKT1_ANTEL reviewed KappaPI-actitoxin-Ael3a (KappaPI-AITX-Ael3a) (Kunitz-type serine protease inhibitor APEKTx1) 0 Anthopleura elegantissima (Sea anemone) 65 0 GO:0004867; GO:0005576; GO:0019870; GO:0042151 0 0 0 PF00014; Q04592 CHOYP_EIN_341640.1.7 m.33585 sp PCSK5_MOUSE 23.343 724 392 41 100 708 856 1531 1.50E-07 58.9 PCSK5_MOUSE reviewed Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6) (Subtilisin/kexin-like protease PC5) Pcsk5 Mus musculus (Mouse) 1877 anterior/posterior pattern specification [GO:0009952]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; cytokine biosynthetic process [GO:0042089]; determination of left/right symmetry [GO:0007368]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; heart development [GO:0007507]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; nerve growth factor processing [GO:0032455]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058] GO:0001822; GO:0002001; GO:0003279; GO:0004175; GO:0004252; GO:0005615; GO:0005788; GO:0005794; GO:0006465; GO:0007368; GO:0007507; GO:0007566; GO:0008233; GO:0009952; GO:0016021; GO:0016485; GO:0016486; GO:0019058; GO:0030141; GO:0030323; GO:0032455; GO:0035108; GO:0042089; GO:0042277; GO:0043043; GO:0048566; GO:0048706; GO:0060976 0 0 0 PF15913;PF14843;PF01483;PF00082;PF16470; Q09288 CHOYP_YQK4.1.2 m.27516 sp YQK4_CAEEL 22.382 487 327 15 160 610 25 496 1.50E-16 86.7 YQK4_CAEEL reviewed Uncharacterized protein C56G2.4 C56G2.4 Caenorhabditis elegans 538 0 0 0 0 0 PF01161; Q13442 CHOYP_LOC100370246.2.2 m.45836 sp HAP28_HUMAN 66.667 78 25 1 91 168 73 149 1.50E-25 100 HAP28_HUMAN reviewed 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) PDAP1 HASPP28 Homo sapiens (Human) 181 cell proliferation [GO:0008283]; signal transduction [GO:0007165] GO:0007165; GO:0008283; GO:0044822 0 0 0 PF10252; Q13442 CHOYP_LOC585338.2.2 m.40817 sp HAP28_HUMAN 66.667 78 25 1 91 168 73 149 1.50E-25 100 HAP28_HUMAN reviewed 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) PDAP1 HASPP28 Homo sapiens (Human) 181 cell proliferation [GO:0008283]; signal transduction [GO:0007165] GO:0007165; GO:0008283; GO:0044822 0 0 0 PF10252; Q13442 CHOYP_YBOXH.4.4 m.45830 sp HAP28_HUMAN 66.667 78 25 1 91 168 73 149 1.50E-25 100 HAP28_HUMAN reviewed 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) PDAP1 HASPP28 Homo sapiens (Human) 181 cell proliferation [GO:0008283]; signal transduction [GO:0007165] GO:0007165; GO:0008283; GO:0044822 0 0 0 PF10252; Q16FT5 CHOYP_COQ4.1.1 m.6843 sp COQ4_AEDAE 55.455 220 98 0 60 279 50 269 1.50E-87 265 COQ4_AEDAE reviewed "Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (Coenzyme Q biosynthesis protein 4 homolog)" AAEL014646 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 274 ubiquinone biosynthetic process [GO:0006744] GO:0006744; GO:0031314 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03111}. 0 0 PF05019; Q23551 CHOYP_LOC100367089.1.4 m.1400 sp UNC22_CAEEL 37.654 162 95 4 1 161 6632 6788 1.50E-27 111 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q28EH9 CHOYP_BRAFLDRAFT_111390.1.1 m.41508 sp NEMP1_XENTR 35.144 313 183 9 45 345 126 430 1.50E-54 189 NEMP1_XENTR reviewed Nuclear envelope integral membrane protein 1 nemp1 tmem194a TTpA010p19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 431 eye development [GO:0001654] GO:0001654; GO:0005635; GO:0005637; GO:0016021 0 0 0 PF10225; Q2T9V8 CHOYP_LOC100556247.2.3 m.25822 sp DTD1_BOVIN 65.693 137 47 0 28 164 12 148 1.50E-63 198 DTD1_BOVIN reviewed D-tyrosyl-tRNA(Tyr) deacylase 1 (EC 3.1.-.-) (DNA-unwinding element-binding protein B) (DUE-B) DTD1 HARS2 Bos taurus (Bovine) 209 D-amino acid catabolic process [GO:0019478]; DNA replication [GO:0006260]; tRNA metabolic process [GO:0006399] GO:0002161; GO:0003677; GO:0005634; GO:0005737; GO:0006260; GO:0006399; GO:0019478; GO:0046872; GO:0051500 0 0 cd00563; PF02580; Q2TA29 CHOYP_RB11A.2.2 m.55376 sp RB11A_BOVIN 54.146 205 92 1 35 237 9 213 1.50E-75 231 RB11A_BOVIN reviewed Ras-related protein Rab-11A RAB11A Bos taurus (Bovine) 216 cell cycle [GO:0007049]; exocytosis [GO:0006887]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005886; GO:0006887; GO:0007049; GO:0007264; GO:0015031; GO:0031175; GO:0032154; GO:0032402; GO:0045335; GO:0055037; GO:0055038; GO:0072659 0 0 0 PF00071; Q32NQ8 CHOYP_CRIM1.3.3 m.8058 sp RNF10_XENLA 39.226 775 377 25 34 776 41 753 1.50E-144 446 RNF10_XENLA reviewed RING finger protein 10 rnf10 Xenopus laevis (African clawed frog) 756 "negative regulation of Schwann cell proliferation [GO:0010626]; positive regulation of myelination [GO:0031643]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0008270; GO:0010626; GO:0031643; GO:0044212; GO:0045944 0 0 0 PF00097; Q32PV0 CHOYP_GULP1.1.1 m.44407 sp GULP1_DANRE 46.037 328 135 7 89 416 11 296 1.50E-80 253 GULP1_DANRE reviewed PTB domain-containing engulfment adapter protein 1 (Cell death protein 6 homolog) (PTB domain adapter protein CED-6) gulp1 ced6 si:ch211-198b21.4 si:xx-35d8.1 Danio rerio (Zebrafish) (Brachydanio rerio) 300 apoptotic process [GO:0006915]; phagocytosis [GO:0006909] GO:0005737; GO:0006909; GO:0006915 0 0 0 PF00640; Q3U288 CHOYP_ZNF710.2.2 m.40760 sp ZN710_MOUSE 62.963 135 48 2 70 203 274 407 1.50E-53 184 ZN710_MOUSE reviewed Zinc finger protein 710 Znf710 Zfp710 Mus musculus (Mouse) 666 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003712; GO:0005634; GO:0006351; GO:0006357; GO:0046872 0 0 0 PF13912; Q495B1 CHOYP_LOC100372378.1.1 m.57166 sp AKD1A_HUMAN 39.511 491 282 4 29 508 8 494 1.50E-121 370 AKD1A_HUMAN reviewed Ankyrin repeat and death domain-containing protein 1A ANKDD1A Homo sapiens (Human) 522 signal transduction [GO:0007165] GO:0007165 0 0 0 PF00023;PF12796; Q55E58 CHOYP_NEMVEDRAFT_V1G199564.4.6 m.54685 sp PATS1_DICDI 23.242 327 208 9 79 394 1793 2087 1.50E-13 79.3 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q55G87 CHOYP_LOC580840.1.1 m.45393 sp CANB1_DICDI 24.419 172 128 1 1 172 1 170 1.50E-15 73.6 CANB1_DICDI reviewed Calcineurin subunit B type 1 (Calcineurin regulatory subunit 1) (Protein phosphatase 2B regulatory subunit 1) cnbA DDB_G0267446 Dictyostelium discoideum (Slime mold) 180 positive regulation of sorocarp stalk cell differentiation [GO:0031287]; protein dephosphorylation [GO:0006470]; response to cation stress [GO:0043157] GO:0005509; GO:0005955; GO:0006470; GO:0031287; GO:0043157 0 0 0 PF13499; Q568Q0 CHOYP_BRAFLDRAFT_86473.1.1 m.27794 sp NUD18_DANRE 33.824 340 182 8 22 340 8 325 1.50E-50 174 NUD18_DANRE reviewed "8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18)" nudt18 zgc:110174 Danio rerio (Zebrafish) (Brachydanio rerio) 325 dADP catabolic process [GO:0046057]; dGDP catabolic process [GO:0046067]; GDP catabolic process [GO:0046712] GO:0000287; GO:0044715; GO:0044716; GO:0044717; GO:0046057; GO:0046067; GO:0046712 0 0 0 PF00293; Q5D018 CHOYP_LOC100881900.3.3 m.63740 sp RBM8A_DANRE 84.615 91 14 0 9 99 64 154 1.50E-54 170 RBM8A_DANRE reviewed RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A) rbm8a rbm8 zgc:110525 Danio rerio (Zebrafish) (Brachydanio rerio) 174 "mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0000381; GO:0003729; GO:0005737; GO:0006397; GO:0006417; GO:0008380; GO:0016607; GO:0035145; GO:0051028 0 0 0 PF00076; Q5JU69 CHOYP_TOR2A.1.1 m.18300 sp TOR2A_HUMAN 31.09 312 169 9 143 431 28 316 1.50E-40 150 TOR2A_HUMAN reviewed Torsin-2A (Torsin family 2 member A) (Torsin-related protein 1) TOR2A TORP1 UNQ6408/PRO21181 Homo sapiens (Human) 321 chaperone mediated protein folding requiring cofactor [GO:0051085]; protein homooligomerization [GO:0051260] GO:0005524; GO:0005788; GO:0051085; GO:0051260 0 0 0 PF06309; Q5RJ80 CHOYP_LOC100697720.1.2 m.5790 sp CAPR2_DANRE 35.821 134 69 6 257 379 784 911 1.50E-10 66.6 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5XGZ9 CHOYP_BRAFLDRAFT_275402.1.1 m.54487 sp MF6LB_XENLA 28.892 623 412 13 6 615 4 608 1.50E-74 253 MF6LB_XENLA reviewed Major facilitator superfamily domain-containing protein 6-like protein B mfsd6l-b Xenopus laevis (African clawed frog) 614 0 GO:0016021 0 0 cd06174; PF12832; Q61847 CHOYP_MEP1B.2.4 m.13941 sp MEP1B_MOUSE 28.324 346 208 16 71 396 104 429 1.50E-23 106 MEP1B_MOUSE reviewed Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) Mep1b Mep-1b Mus musculus (Mouse) 704 inflammatory response [GO:0006954]; toxin transport [GO:1901998] GO:0004222; GO:0005576; GO:0005886; GO:0006954; GO:0008270; GO:0016020; GO:0016021; GO:1901998 0 0 cd06263; PF01400;PF00008;PF00629; Q66IM5 CHOYP_BRAFLDRAFT_124064.1.6 m.5120 sp NATD1_XENTR 38.298 94 56 1 21 114 8 99 1.50E-16 72.4 NATD1_XENTR reviewed Protein NATD1 (N-acetyltransferase domain-containing protein 1) natd1 gtlf3b TEgg042j15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 109 0 0 0 0 0 PF14542; Q66IM5 CHOYP_LOC581921.1.1 m.24262 sp NATD1_XENTR 38.298 94 56 1 21 114 8 99 1.50E-16 72.4 NATD1_XENTR reviewed Protein NATD1 (N-acetyltransferase domain-containing protein 1) natd1 gtlf3b TEgg042j15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 109 0 0 0 0 0 PF14542; Q6DFJ6 CHOYP_TBK1.4.5 m.40692 sp TBK1_XENLA 35 700 402 11 11 699 3 660 1.50E-125 400 TBK1_XENLA reviewed Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) tbk1 Xenopus laevis (African clawed frog) 725 innate immune response [GO:0045087] GO:0004674; GO:0005524; GO:0005737; GO:0045087 0 0 0 PF00069; Q6DN90 CHOYP_SIZ.1.1 m.4276 sp IQEC1_HUMAN 52.822 443 170 5 550 968 521 948 1.50E-147 468 IQEC1_HUMAN reviewed IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) IQSEC1 ARFGEP100 BRAG2 KIAA0763 Homo sapiens (Human) 963 actin cytoskeleton organization [GO:0030036]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005634; GO:0005737; GO:0008289; GO:0016020; GO:0030036; GO:0032012 0 0 0 PF01369; Q6PGY5 CHOYP_NEMVEDRAFT_V1G201862.1.1 m.11025 sp DJC21_DANRE 41.084 572 282 12 5 551 1 542 1.50E-126 384 DJC21_DANRE reviewed DnaJ homolog subfamily C member 21 (DnaJ homolog subfamily A member 5) dnajc21 dnaja5 zgc:63563 Danio rerio (Zebrafish) (Brachydanio rerio) 545 0 GO:0003676; GO:0008270 0 0 cd06257; PF00226;PF12756;PF12171; Q6ZRF8 CHOYP_LOC100374741.75.83 m.60856 sp RN207_HUMAN 22.703 185 129 6 36 217 114 287 1.50E-06 54.3 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8BTK5 CHOYP_LOC100372698.1.1 m.18674 sp SMYD4_MOUSE 27.591 685 400 17 52 673 58 709 1.50E-51 194 SMYD4_MOUSE reviewed SET and MYND domain-containing protein 4 (EC 2.1.1.-) Smyd4 Kiaa1936 Mus musculus (Mouse) 799 0 GO:0008168; GO:0046872 0 0 0 PF00856;PF01753; Q8BUV8 CHOYP_BRAFLDRAFT_121259.1.1 m.2411 sp GP107_MOUSE 42.959 561 258 13 30 586 33 535 1.50E-152 453 GP107_MOUSE reviewed Protein GPR107 Gpr107 Kiaa1624 Mus musculus (Mouse) 551 clathrin-mediated endocytosis [GO:0072583] GO:0005769; GO:0005794; GO:0016021; GO:0030136; GO:0032050; GO:0072583 0 0 0 PF06814; Q8N6F8 CHOYP_NEMVEDRAFT_V1G245969.1.2 m.347 sp WBS27_HUMAN 32.544 169 110 3 36 204 32 196 1.50E-24 100 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q8NDA2 CHOYP_DWIL_GK20677.1.2 m.33788 sp HMCN2_HUMAN 24.536 485 294 24 57 492 2671 3132 1.50E-13 79 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8NFD2 CHOYP_TVAG_168010.45.45 m.64706 sp ANKK1_HUMAN 39.568 139 84 0 4 142 413 551 1.50E-22 98.2 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8SWR3 CHOYP_LOC100118228.1.3 m.26894 sp SPR_DROME 28.826 281 189 7 1 276 131 405 1.50E-27 114 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q90694 CHOYP_CDC42.6.11 m.35674 sp CDC42_CHICK 45.856 181 92 1 38 212 5 185 1.50E-50 166 CDC42_CHICK reviewed Cell division control protein 42 homolog (G25K GTP-binding protein) CDC42 Gallus gallus (Chicken) 191 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; adherens junction organization [GO:0034332]; canonical Wnt signaling pathway [GO:0060070]; cardiac conduction system development [GO:0003161]; cellular protein localization [GO:0034613]; dendritic cell migration [GO:0036336]; endocytosis [GO:0006897]; epidermis morphogenesis [GO:0048730]; epithelial cell-cell adhesion [GO:0090136]; epithelial-mesenchymal cell signaling [GO:0060684]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; heart contraction [GO:0060047]; keratinization [GO:0031424]; keratinocyte development [GO:0003334]; maintenance of protein location [GO:0045185]; multicellular organism growth [GO:0035264]; negative regulation of gene expression [GO:0010629]; negative regulation of protein complex assembly [GO:0031333]; neuron fate determination [GO:0048664]; nuclear migration [GO:0007097]; positive regulation of cell growth [GO:0030307]; positive regulation of cytokinesis [GO:0032467]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of gene expression [GO:0010628]; positive regulation of hair follicle cell proliferation [GO:0071338]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of filopodium assembly [GO:0051489]; regulation of mitotic nuclear division [GO:0007088]; regulation of protein catabolic process [GO:0042176]; regulation of protein heterodimerization activity [GO:0043497]; regulation of protein stability [GO:0031647]; small GTPase mediated signal transduction [GO:0007264]; substantia nigra development [GO:0021762] GO:0000322; GO:0003161; GO:0003334; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005912; GO:0005925; GO:0006897; GO:0007088; GO:0007097; GO:0007264; GO:0010628; GO:0010629; GO:0021762; GO:0030036; GO:0030175; GO:0030307; GO:0030496; GO:0031256; GO:0031274; GO:0031333; GO:0031424; GO:0031647; GO:0032467; GO:0033138; GO:0034332; GO:0034613; GO:0035088; GO:0035264; GO:0036336; GO:0036464; GO:0042176; GO:0042995; GO:0043005; GO:0043025; GO:0043209; GO:0043410; GO:0043497; GO:0043552; GO:0045177; GO:0045185; GO:0045860; GO:0046847; GO:0048664; GO:0048730; GO:0051017; GO:0051233; GO:0051489; GO:0051988; GO:0060047; GO:0060070; GO:0060501; GO:0060684; GO:0061630; GO:0070062; GO:0071338; GO:0072686; GO:0090136; GO:1900026 0 0 0 PF00071; Q92626 CHOYP_TITIN.14.19 m.56294 sp PXDN_HUMAN 24.812 399 259 16 199 586 247 615 1.50E-08 63.5 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q94126 CHOYP_ISCW_ISCW006531.1.1 m.39741 sp CES2_CAEEL 56.41 78 34 0 296 373 100 177 1.50E-20 92 CES2_CAEEL reviewed Cell death specification protein 2 ces-2 ZK909.4 Caenorhabditis elegans 211 apoptotic process [GO:0006915]; multicellular organism development [GO:0007275]; positive regulation of programmed cell death [GO:0043068] GO:0000977; GO:0001012; GO:0001077; GO:0003700; GO:0005634; GO:0006915; GO:0007275; GO:0043068; GO:0043565 0 0 0 PF07716; Q95SX7 CHOYP_LOC100561123.16.28 m.20803 sp RTBS_DROME 31.641 256 165 6 189 440 349 598 1.50E-22 104 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q96DM1 CHOYP_PGBD4.1.2 m.10525 sp PGBD4_HUMAN 37.336 458 265 10 2 451 142 585 1.50E-94 300 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q96LX7 CHOYP_LOC100374809.1.1 m.59170 sp CCD17_HUMAN 28.251 223 126 8 54 269 121 316 1.50E-12 73.9 CCD17_HUMAN reviewed Coiled-coil domain-containing protein 17 CCDC17 Homo sapiens (Human) 622 0 0 0 0 0 0 Q99572 CHOYP_P2RX7.1.1 m.35757 sp P2RX7_HUMAN 29.286 140 85 3 68 195 456 593 1.50E-13 72 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; Q9D5I4 CHOYP_ODA-LC2.1.2 m.30527 sp TC1D1_MOUSE 33.108 148 88 2 113 260 37 173 1.50E-18 83.6 TC1D1_MOUSE reviewed Tctex1 domain-containing protein 1 Tctex1d1 Mus musculus (Mouse) 173 0 0 0 0 0 PF03645; Q9DAN9 CHOYP_LOC577213.1.1 m.30836 sp CQ105_MOUSE 38 150 91 1 4 151 9 158 1.50E-24 99 CQ105_MOUSE reviewed Uncharacterized protein C17orf105 homolog 0 Mus musculus (Mouse) 164 0 0 0 0 0 PF13879; Q9ESN6 CHOYP_TRIM2.43.59 m.47089 sp TRIM2_MOUSE 24.545 220 145 6 70 286 506 707 1.50E-09 62.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HCD6 CHOYP_AOR_1_1386094.2.6 m.3899 sp TANC2_HUMAN 40.116 172 103 0 1 172 1054 1225 1.50E-30 119 TANC2_HUMAN reviewed "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" TANC2 KIAA1148 KIAA1636 Homo sapiens (Human) 1990 in utero embryonic development [GO:0001701] GO:0001701 0 0 0 PF00023;PF12796;PF13181; Q9NUV9 CHOYP_GIMA4.2.7 m.29773 sp GIMA4_HUMAN 29.861 144 79 5 7 147 31 155 1.50E-07 54.3 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9R1R2 CHOYP_BRAFLDRAFT_87332.3.6 m.39248 sp TRIM3_MOUSE 26.829 123 86 3 71 190 622 743 1.50E-06 51.6 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UGM3 CHOYP_SRB4D.1.1 m.54786 sp DMBT1_HUMAN 44.649 271 139 5 5 271 714 977 1.50E-56 198 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UPY6 CHOYP_LOC662022.1.1 m.47145 sp WASF3_HUMAN 45.631 206 111 1 1 206 1 205 1.50E-50 183 WASF3_HUMAN reviewed Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3) WASF3 KIAA0900 SCAR3 WAVE3 Homo sapiens (Human) 502 actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; oligodendrocyte development [GO:0014003]; positive regulation of myelination [GO:0031643]; protein complex assembly [GO:0006461]; regulation of cell shape [GO:0008360] GO:0005737; GO:0005856; GO:0006461; GO:0007010; GO:0008360; GO:0014003; GO:0030027; GO:0030032; GO:0030041; GO:0031643; GO:0070062 0 0 0 PF02205; Q9VCA8 CHOYP_LOC100641396.24.27 m.60251 sp ANKHM_DROME 33.077 520 296 23 867 1352 545 1046 1.50E-42 175 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9Y493 CHOYP_NEMVEDRAFT_V1G247997.3.3 m.60754 sp ZAN_HUMAN 32.907 313 168 7 874 1149 676 983 1.50E-18 96.7 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A2AJ76 CHOYP_contig_030888 m.35216 sp HMCN2_MOUSE 22.667 375 240 16 275 625 2359 2707 1.51E-09 67 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A3KPQ7 CHOYP_TMEM2.1.4 m.6314 sp TMEM2_DANRE 27.219 1014 608 30 12 951 189 1146 1.51E-94 331 TMEM2_DANRE reviewed Transmembrane protein 2 tmem2 si:dkey-24k20.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1378 atrioventricular valve formation [GO:0003190]; cell migration to the midline involved in heart development [GO:0003318]; heart looping [GO:0001947] GO:0001947; GO:0003190; GO:0003318; GO:0016021 0 0 0 PF10162; A9CPT4 CHOYP_MYCGRDRAFT_89575.9.12 m.52993 sp TDRD1_ORYLA 40 55 30 2 7 61 75 126 1.51E-06 50.1 TDRD1_ORYLA reviewed Tudor domain-containing protein 1 tdrd1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 1133 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0007275; GO:0007281; GO:0007283; GO:0031047; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; D3YXG0 CHOYP_HMCN2.12.12 m.56632 sp HMCN1_MOUSE 26.003 1496 882 67 314 1739 480 1820 1.51E-79 298 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D4GU72 CHOYP_LOC100377323.1.1 m.23683 sp AGL12_HALVD 27.152 302 201 10 51 338 3 299 1.51E-20 94 AGL12_HALVD reviewed Low-salt glycan biosynthesis protein Agl12 (EC 4.2.1.-) agl12 HVO_2059 C498_05583 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) 310 nucleotide-sugar metabolic process [GO:0009225]; protein glycosylation [GO:0006486]; S-layer organization [GO:0045232] GO:0006486; GO:0008460; GO:0009225; GO:0045232 PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:24194539}.; PATHWAY: Cell surface structure biogenesis; S-layer biogenesis. {ECO:0000269|PubMed:24194539}. 0 0 PF16363; E9Q6J5 CHOYP_LOC100373080.3.6 m.13364 sp BD1L1_MOUSE 54.808 104 47 0 12 115 50 153 1.51E-33 145 BD1L1_MOUSE reviewed Biorientation of chromosomes in cell division protein 1-like 1 Bod1l Kiaa1327 Mus musculus (Mouse) 3032 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] GO:0003677; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0031297 0 0 0 0 F4KGU4 CHOYP_LOC100632169.1.6 m.18584 sp DEAHC_ARATH 22.057 671 461 20 8 643 860 1503 1.51E-26 119 DEAHC_ARATH reviewed "ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)" At5g10370 F12B17_280 Arabidopsis thaliana (Mouse-ear cress) 1775 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006396; GO:0008270; GO:0009507; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF01485;PF07717;PF13445; O14523 CHOYP_LOC658718.1.2 m.141 sp C2C2L_HUMAN 24.104 502 306 15 5 471 4 465 1.51E-23 109 C2C2L_HUMAN reviewed C2 domain-containing protein 2-like (Transmembrane protein 24) C2CD2L KIAA0285 TMEM24 DLNB23 Homo sapiens (Human) 706 positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] GO:0016021; GO:0035774 0 0 0 0 O75382 CHOYP_BRAFLDRAFT_206799.21.23 m.59560 sp TRIM3_HUMAN 26.613 124 88 2 36 156 620 743 1.51E-06 53.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_71598.5.10 m.20668 sp TRIM3_HUMAN 26.357 129 86 3 103 229 622 743 1.51E-08 58.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P07572 CHOYP_LOC100495321.2.3 m.51792 sp POL_MPMV 23.794 311 182 12 86 381 45 315 1.51E-06 55.1 POL_MPMV reviewed Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) 867 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P10160 CHOYP_EIF5A.3.3 m.64289 sp IF5A1_RABIT 63.924 158 52 2 12 169 1 153 1.51E-69 210 IF5A1_RABIT reviewed Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) EIF5A Oryctolagus cuniculus (Rabbit) 154 mRNA transport [GO:0051028]; positive regulation of translation [GO:0045727]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; protein transport [GO:0015031]; translational frameshifting [GO:0006452] GO:0003746; GO:0005643; GO:0005789; GO:0006452; GO:0015031; GO:0043022; GO:0045727; GO:0045901; GO:0045905; GO:0051028 0 0 0 PF01287; P10394 CHOYP_contig_016287 m.19145 sp POL4_DROME 31.013 977 584 19 320 1233 274 1223 1.51E-133 448 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P20072 CHOYP_ANXA7.4.4 m.50772 sp ANXA7_BOVIN 53.363 223 80 4 57 271 120 326 1.51E-65 214 ANXA7_BOVIN reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 Bos taurus (Bovine) 463 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005509; GO:0005544; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0030855; GO:0035176; GO:0042584; GO:0042802; GO:0044822; GO:0048306; GO:0070062 0 0 0 PF00191; P21328 CHOYP_LOC752194.11.12 m.52141 sp RTJK_DROME 25.385 390 263 11 3 379 499 873 1.51E-23 109 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P21329 CHOYP_RTJK.1.3 m.35698 sp RTJK_DROFU 25.831 391 270 7 1 381 457 837 1.51E-32 136 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P22105 CHOYP_MEGF6.42.59 m.47035 sp TENX_HUMAN 28.302 530 263 42 174 632 189 672 1.51E-30 133 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P22488 CHOYP_LOC100533447.2.3 m.44496 sp IFEA_HELAS 35.511 597 339 4 18 612 18 570 1.51E-109 343 IFEA_HELAS reviewed Non-neuronal cytoplasmic intermediate filament protein (IF) 0 Helix aspersa (Brown garden snail) (Cornu aspersum) 576 0 GO:0005198; GO:0005737; GO:0005882 0 0 0 PF00038; P23471 CHOYP_PTPRZ.1.9 m.12735 sp PTPRZ_HUMAN 46.087 115 49 3 125 227 1699 1812 1.51E-19 90.1 PTPRZ_HUMAN reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) 2315 axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; hematopoietic progenitor cell differentiation [GO:0002244]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; protein dephosphorylation [GO:0006470]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0002244; GO:0004725; GO:0005001; GO:0005578; GO:0005615; GO:0005737; GO:0005887; GO:0006470; GO:0007409; GO:0007413; GO:0007417; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0021766; GO:0030027; GO:0030175; GO:0030424; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; P27074 CHOYP_BRAFLDRAFT_118620.3.3 m.58591 sp RL44Q_CANMA 71.875 96 27 0 1 96 1 96 1.51E-45 160 RL44Q_CANMA reviewed 60S ribosomal protein L44 Q (L41) (L41 Q-type) RIM-C L41Q1A Candida maltosa (Yeast) 106 response to antibiotic [GO:0046677]; response to cycloheximide [GO:0046898]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046677; GO:0046898 0 0 0 PF00935; P27658 CHOYP_CO8A2.1.2 m.62403 sp CO8A1_HUMAN 31.25 112 74 2 90 199 628 738 1.51E-08 57.4 CO8A1_HUMAN reviewed Collagen alpha-1(VIII) chain (Endothelial collagen) [Cleaved into: Vastatin] COL8A1 C3orf7 Homo sapiens (Human) 744 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; endodermal cell differentiation [GO:0035987]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0001525; GO:0005576; GO:0005591; GO:0005788; GO:0007155; GO:0010811; GO:0030198; GO:0030574; GO:0031012; GO:0035987; GO:0043231; GO:0048593; GO:0050673; GO:0070062 0 0 0 PF00386;PF01391; P35658 CHOYP_NUP214.1.3 m.16350 sp NU214_HUMAN 36.341 399 237 10 5 391 11 404 1.51E-79 297 NU214_HUMAN reviewed Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) NUP214 CAIN CAN KIAA0023 Homo sapiens (Human) 2090 gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein sumoylation [GO:0016925]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of mRNA stability [GO:0043488]; RNA export from nucleus [GO:0006405]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005049; GO:0005634; GO:0005654; GO:0005829; GO:0005925; GO:0006405; GO:0006406; GO:0006409; GO:0006606; GO:0006611; GO:0007077; GO:0008139; GO:0010827; GO:0016032; GO:0016925; GO:0017056; GO:0019083; GO:0031047; GO:0043231; GO:0043488; GO:0051726; GO:0075733; GO:1900034; GO:1990876 0 0 0 0 P36544 CHOYP_EPHA7.1.1 m.9185 sp ACHA7_HUMAN 28.302 318 221 6 11 326 8 320 1.51E-35 139 ACHA7_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 NACHRA7 Homo sapiens (Human) 502 "activation of MAPK activity [GO:0000187]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; cognition [GO:0050890]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; memory [GO:0007613]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0000187; GO:0001540; GO:0001666; GO:0004889; GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0007613; GO:0008284; GO:0015276; GO:0015464; GO:0015643; GO:0016021; GO:0017081; GO:0022848; GO:0030054; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042803; GO:0045211; GO:0045766; GO:0050890 0 0 0 PF02931;PF02932; P54985 CHOYP_LOC101156984.2.2 m.22956 sp PPIA_BLAGE 78.049 164 36 0 1 164 1 164 1.51E-93 271 PPIA_BLAGE reviewed Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) CYPA Blattella germanica (German cockroach) (Blatta germanica) 164 protein folding [GO:0006457] GO:0003755; GO:0005737; GO:0006457; GO:0042277 0 0 0 PF00160; P68106 CHOYP_LOC658057.1.1 m.43960 sp FKB1B_HUMAN 44.762 105 55 2 21 122 2 106 1.51E-25 96.3 FKB1B_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12) FKBP1B FKBP12.6 FKBP1L FKBP9 OTK4 Homo sapiens (Human) 108 'de novo' protein folding [GO:0006458]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; chaperone-mediated protein folding [GO:0061077]; insulin secretion [GO:0030073]; ion transmembrane transport [GO:0034220]; negative regulation of heart rate [GO:0010459]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of protein phosphatase type 2B activity [GO:0032513]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neuronal action potential propagation [GO:0019227]; positive regulation of axon regeneration [GO:0048680]; positive regulation of sequestering of calcium ion [GO:0051284]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to redox state [GO:0051775]; response to vitamin E [GO:0033197]; smooth muscle contraction [GO:0006939]; T cell proliferation [GO:0042098] GO:0000413; GO:0003755; GO:0005102; GO:0005528; GO:0005737; GO:0005829; GO:0006458; GO:0006939; GO:0009749; GO:0010459; GO:0010880; GO:0010881; GO:0014808; GO:0016020; GO:0019227; GO:0019855; GO:0022417; GO:0030018; GO:0030073; GO:0030551; GO:0032513; GO:0033017; GO:0033197; GO:0034220; GO:0034704; GO:0035584; GO:0042026; GO:0042098; GO:0042542; GO:0044325; GO:0048680; GO:0051280; GO:0051284; GO:0051480; GO:0051775; GO:0060314; GO:0060315; GO:0061077; GO:0061179; GO:0086064; GO:1903779 0 0 0 PF00254; P80109 CHOYP_LOC590298.2.3 m.4191 sp PHLD_BOVIN 33.62 815 502 21 40 836 25 818 1.51E-133 422 PHLD_BOVIN reviewed Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) 839 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytolysis [GO:0045919]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633] GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0005578; GO:0005615; GO:0005737; GO:0006507; GO:0008285; GO:0008286; GO:0009749; GO:0010595; GO:0010694; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0032869; GO:0034364; GO:0035690; GO:0035774; GO:0043065; GO:0043231; GO:0045919; GO:0046470; GO:0051044; GO:0051047; GO:0070633; GO:0071277; GO:0071397; GO:0071401; GO:0071467; GO:1900076 0 0 0 PF01839;PF00882; Q00PJ9 CHOYP_TRIADDRAFT_56887.1.1 m.30985 sp CAV1_ATEAB 34.454 119 77 1 23 140 53 171 1.51E-16 77.8 CAV1_ATEAB reviewed Caveolin-1 CAV1 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) 178 caveola assembly [GO:0070836]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; receptor internalization [GO:0031623]; T cell costimulation [GO:0031295] GO:0000139; GO:0005768; GO:0005901; GO:0030512; GO:0031295; GO:0031623; GO:0045121; GO:0070836 0 0 0 PF01146; Q03601 CHOYP_BRAFLDRAFT_206799.6.23 m.23954 sp NHL1_CAEEL 29.358 109 70 3 9 110 772 880 1.51E-06 53.9 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q09575 CHOYP_LOC100891945.1.1 m.29986 sp YRD6_CAEEL 31.778 343 207 5 20 352 729 1054 1.51E-49 184 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q0IIB1 CHOYP_PHYD1.2.2 m.22773 sp PHYD1_BOVIN 54.452 292 123 5 2 287 3 290 1.51E-108 319 PHYD1_BOVIN reviewed Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC 1.-.-.-) PHYHD1 Bos taurus (Bovine) 291 0 GO:0046872; GO:0051213 0 0 0 PF05721; Q148E0 CHOYP_SORBIDRAFT_01G038790.1.1 m.10795 sp AAED1_BOVIN 29.71 138 82 4 11 141 88 217 1.51E-06 49.7 AAED1_BOVIN reviewed Thioredoxin-like protein AAED1 (AhpC/TSA antioxidant enzyme domain-containing protein 1) AAED1 Bos taurus (Bovine) 228 oxidation-reduction process [GO:0055114] GO:0016209; GO:0055114 0 0 0 PF13911; Q1PSW8 CHOYP_BRAFLDRAFT_87327.3.13 m.32720 sp LIN41_MOUSE 28.169 142 85 4 114 242 697 834 1.51E-07 55.1 LIN41_MOUSE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to organic substance [GO:0071310]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of protein metabolic process [GO:0051246]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0017148; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051246; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0071310; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q20930 CHOYP_LOC101065745.1.1 m.58641 sp MIG17_CAEEL 32.645 242 143 11 14 241 227 462 1.51E-26 117 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q29496 CHOYP_CP3A4.1.1 m.43020 sp CP3AO_SHEEP 42.157 510 272 9 29 534 1 491 1.51E-142 423 CP3AO_SHEEP reviewed Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) 503 0 GO:0004497; GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q2KI23 CHOYP_FA63B.1.1 m.52872 sp FA63B_BOVIN 56.995 386 135 7 165 536 242 610 1.51E-128 392 FA63B_BOVIN reviewed Ubiquitin carboxyl-terminal hydrolase MINDY-2 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-2) (Protein FAM63B) FAM63B Bos taurus (Bovine) 630 0 GO:0005654 0 0 0 PF04424; Q2TBL4 CHOYP_RPC3.1.3 m.1434 sp RPC3_BOVIN 48.493 365 165 8 7 352 144 504 1.51E-110 335 RPC3_BOVIN reviewed DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) POLR3C Bos taurus (Bovine) 533 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003677; GO:0003899; GO:0005666; GO:0006383; GO:0032728; GO:0045087; GO:0045089; GO:0051607 0 0 0 PF08221;PF05645; Q3SZQ6 CHOYP_BRAFLDRAFT_114866.4.5 m.35626 sp RL32_BOVIN 48.201 139 60 2 38 170 3 135 1.51E-34 120 RL32_BOVIN reviewed 60S ribosomal protein L32 RPL32 Bos taurus (Bovine) 135 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 cd00513; PF01655; Q460N5 CHOYP_PAR14.14.17 m.57845 sp PAR14_HUMAN 31.765 765 479 17 1 756 1070 1800 1.51E-108 367 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4KGS0 CHOYP_BRAFLDRAFT_287444.5.5 m.31201 sp UNG_PSEF5 60.656 61 24 0 69 129 13 73 1.51E-19 83.6 UNG_PSEF5 reviewed Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung PFL_1435 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 230 base-excision repair [GO:0006284] GO:0004844; GO:0005737; GO:0006284 0 0 cd10027; PF03167; Q4R6X9 CHOYP_LOC101164482.1.1 m.44587 sp DRC3_MACFA 41.358 162 95 0 3 164 214 375 1.51E-33 126 DRC3_MACFA reviewed Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48) DRC3 LRRC48 QtsA-16881 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 523 0 GO:0005737; GO:0005856; GO:0042995 0 0 0 0 Q4V842 CHOYP_BRAFLDRAFT_226459.1.1 m.19543 sp GPTC4_XENLA 62.5 80 30 0 5 84 13 92 1.51E-30 113 GPTC4_XENLA reviewed G patch domain-containing protein 4 gpatch4 gpatc4 Xenopus laevis (African clawed frog) 324 0 GO:0003676 0 0 0 PF01585; Q502K2 CHOYP_NEMVEDRAFT_V1G246030.1.1 m.39781 sp SAMH1_DANRE 55.297 472 197 6 71 531 88 556 1.51E-174 509 SAMH1_DANRE reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) 622 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966;PF07647; Q58EX7 CHOYP_LOC100377600.2.2 m.16039 sp PKHG4_HUMAN 52.699 389 179 2 1000 1384 724 1111 1.51E-127 429 PKHG4_HUMAN reviewed Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) PLEKHG4 PRTPHN1 Homo sapiens (Human) 1191 activation of GTPase activity [GO:0090630]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023; GO:0090630 0 0 0 PF00621; Q5BJ65 CHOYP_H2AV.4.7 m.22800 sp H2AV_XENTR 97.656 128 3 0 13 140 1 128 1.51E-84 246 H2AV_XENTR reviewed Histone H2A.V (H2A.F/Z) h2afv TGas096d24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 chromatin silencing [GO:0006342] GO:0000786; GO:0000790; GO:0003677; GO:0006342 0 0 0 PF00125;PF16211; Q5E951 CHOYP_BRAFLDRAFT_275787.2.2 m.62313 sp TBCB_BOVIN 55.263 228 98 2 7 233 6 230 1.51E-86 260 TBCB_BOVIN reviewed Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) TBCB CKAP1 Bos taurus (Bovine) 244 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; post-chaperonin tubulin folding pathway [GO:0007023] GO:0005654; GO:0005829; GO:0005874; GO:0007023; GO:0007399; GO:0030154 0 0 0 PF01302;PF14560; Q5NYD9 CHOYP_LOC100371716.1.1 m.46204 sp Y3800_AROAE 42.166 517 282 9 66 572 14 523 1.51E-135 407 Y3800_AROAE reviewed UPF0061 protein AZOSEA38000 AZOSEA38000 ebA6654 Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) 523 0 0 0 0 0 PF02696; Q5RB75 CHOYP_LOC100567407.1.1 m.8503 sp NUDC3_PONAB 39.496 357 208 5 29 381 7 359 1.51E-85 267 NUDC3_PONAB reviewed NudC domain-containing protein 3 NUDCD3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 361 0 0 0 0 0 PF04969;PF14050; Q5UR67 CHOYP_LOC100638431.1.10 m.3026 sp RIBX_MIMIV 39.726 146 83 2 326 466 22 167 1.51E-24 103 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5VU97 CHOYP_NEMVEDRAFT_V1G238894.8.11 m.61924 sp CAHD1_HUMAN 26.247 842 541 31 7 793 247 1063 1.51E-63 237 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q68FR3 CHOYP_CD109.1.2 m.7034 sp INT12_RAT 37.879 264 91 8 5 242 8 224 1.51E-42 153 INT12_RAT reviewed Integrator complex subunit 12 (Int12) (PHD finger protein 22) Ints12 Phf22 Rattus norvegicus (Rat) 461 0 GO:0005634; GO:0008270 0 0 0 PF00628; Q6NWF4 CHOYP_LOC100368519.1.1 m.49726 sp VPS25_DANRE 61.111 162 62 1 51 212 14 174 1.51E-67 207 VPS25_DANRE reviewed Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) vps25 Danio rerio (Zebrafish) (Brachydanio rerio) 174 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] GO:0000814; GO:0005198; GO:0042803; GO:0043328 0 0 0 PF05871; Q6RY07 CHOYP_BRAFLDRAFT_281651.2.8 m.5909 sp CHIA_RAT 48.462 130 60 2 2 131 4 126 1.51E-36 132 CHIA_RAT reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) 473 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532] GO:0000272; GO:0002376; GO:0002532; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0006032; GO:0006915; GO:0008061; GO:0090197 0 0 0 PF01607;PF00704; Q7LHG5 CHOYP_LOC100894010.1.6 m.6605 sp YI31B_YEAST 30.662 1223 713 33 9 1184 323 1457 1.51E-135 456 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q80YX1 CHOYP_BRAFLDRAFT_83656.1.1 m.25491 sp TENA_MOUSE 33.69 374 187 13 228 553 1735 2095 1.51E-50 191 TENA_MOUSE reviewed Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) 2110 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] GO:0001649; GO:0001968; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; Q86U86 CHOYP_PB1.3.6 m.12084 sp PB1_HUMAN 38.211 123 45 5 30 149 1378 1472 1.51E-15 75.9 PB1_HUMAN reviewed Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 "chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0003682; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0008285; GO:0016569; GO:0090544 0 0 0 PF01426;PF00439;PF00505; Q8BKE6 CHOYP_BRAFLDRAFT_79625.1.1 m.29588 sp CP20A_MOUSE 32.432 370 235 8 18 383 103 461 1.51E-57 197 CP20A_MOUSE reviewed Cytochrome P450 20A1 (EC 1.14.-.-) Cyp20a1 Mus musculus (Mouse) 462 0 GO:0004497; GO:0005506; GO:0016020; GO:0016021; GO:0016705; GO:0020037 0 0 0 PF00067; Q8BZP8 CHOYP_LOC100890805.1.1 m.52159 sp NPSR1_MOUSE 30.496 141 93 4 66 203 53 191 1.51E-10 66.2 NPSR1_MOUSE reviewed Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) Npsr1 Gpr154 Pgr14 Mus musculus (Mouse) 371 neuropeptide signaling pathway [GO:0007218]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281] GO:0005000; GO:0005737; GO:0005887; GO:0007218; GO:0008188; GO:0051281 0 0 0 PF00001; Q8IRI6 CHOYP_GLUT1.1.1 m.6717 sp GTR1_DROME 55.677 458 203 0 24 481 9 466 1.51E-170 522 GTR1_DROME reviewed Glucose transporter type 1 Glut1 CG43946 Drosophila melanogaster (Fruit fly) 1440 adult chitin-containing cuticle pigmentation [GO:0048085]; carbohydrate transport [GO:0008643]; positive regulation of peptide hormone secretion [GO:0090277]; sensory perception of pain [GO:0019233] GO:0008643; GO:0016021; GO:0019233; GO:0022891; GO:0048085; GO:0090277 0 0 cd06174; PF00083; Q8IZ41 CHOYP_LOC100377113.1.3 m.17119 sp RASEF_HUMAN 28.068 766 467 21 17 732 8 739 1.51E-67 239 RASEF_HUMAN reviewed Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) RASEF RAB45 Homo sapiens (Human) 740 small GTPase mediated signal transduction [GO:0007264] GO:0005509; GO:0005525; GO:0007264; GO:0048471 0 0 0 PF13499;PF00071; Q8IZ81 CHOYP_BRAFLDRAFT_58011.1.1 m.62755 sp ELMD2_HUMAN 48.175 274 141 1 10 283 6 278 1.51E-86 264 ELMD2_HUMAN reviewed ELMO domain-containing protein 2 ELMOD2 Homo sapiens (Human) 293 defense response to virus [GO:0051607]; regulation of defense response to virus [GO:0050688] GO:0005096; GO:0016020; GO:0050688; GO:0051607 0 0 0 PF04727; Q8ND56 CHOYP_LOC101071011.1.1 m.18616 sp LS14A_HUMAN 82 100 12 2 1 99 1 95 1.51E-47 163 LS14A_HUMAN reviewed Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) LSM14A C19orf13 FAM61A RAP55 RAP55A Homo sapiens (Human) 463 cytoplasmic mRNA processing body assembly [GO:0033962]; multicellular organism development [GO:0007275]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of translation [GO:0006417]; RIG-I signaling pathway [GO:0039529] GO:0000932; GO:0003690; GO:0003725; GO:0003727; GO:0005737; GO:0006417; GO:0007275; GO:0010494; GO:0033962; GO:0039529; GO:0043231; GO:0044822; GO:0060340 0 0 0 PF09532;PF12701; Q8TEW0 CHOYP_LOC100371218.3.3 m.42650 sp PARD3_HUMAN 39.973 743 358 22 3 716 1 684 1.51E-125 428 PARD3_HUMAN reviewed Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) 1356 asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell cycle [GO:0007049]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein complex assembly [GO:0006461]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein targeting to membrane [GO:0006612]; regulation of cellular localization [GO:0060341]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005546; GO:0005547; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005923; GO:0005938; GO:0006461; GO:0006612; GO:0007049; GO:0007163; GO:0007179; GO:0007205; GO:0007409; GO:0008356; GO:0010801; GO:0012505; GO:0022011; GO:0030054; GO:0031643; GO:0032266; GO:0033269; GO:0043025; GO:0043234; GO:0044295; GO:0060341; GO:0070830; GO:0090162 0 0 0 PF12053;PF00595; Q91YD4 CHOYP_TRPM2.12.12 m.63752 sp TRPM2_MOUSE 25.399 626 378 22 426 998 486 1075 1.51E-46 186 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q96RW7 CHOYP_BRAFLDRAFT_236936.5.6 m.48363 sp HMCN1_HUMAN 49.415 342 173 0 97 438 4528 4869 1.51E-110 365 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99NH0 CHOYP_LOC578679.1.6 m.20050 sp ANR17_MOUSE 32.468 231 143 8 185 403 229 458 1.51E-23 107 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9ESN6 CHOYP_LOC100373444.20.79 m.24188 sp TRIM2_MOUSE 24.731 279 175 11 305 572 489 743 1.51E-08 61.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HCS5 CHOYP_AGAP_AGAP001632.1.1 m.13394 sp E41LA_HUMAN 40.484 620 275 18 39 607 15 591 1.51E-126 408 E41LA_HUMAN reviewed Band 4.1-like protein 4A (Protein NBL4) EPB41L4A EPB41L4 Homo sapiens (Human) 686 0 GO:0005737; GO:0005856; GO:0019898 0 0 0 PF08736;PF09380;PF00373;PF09379; Q9I9B9 CHOYP_CPIPJ_CPIJ003602.1.1 m.15475 sp CTL1_TORMA 45.192 104 56 1 1 103 524 627 1.51E-23 97.4 CTL1_TORMA reviewed Choline transporter-like protein 1 (Solute carrier family 44 member 1) slc44a1 ctl1 Torpedo marmorata (Marbled electric ray) 646 transport [GO:0006810] GO:0006810; GO:0016021 0 0 0 PF04515; Q9I9M5 CHOYP_FZD1.1.2 m.38887 sp FZD1_XENLA 63.816 152 48 3 22 168 38 187 1.51E-62 209 FZD1_XENLA reviewed Frizzled-1 (Fz-1) (Xfz1) fzd1 fz1 Xenopus laevis (African clawed frog) 559 multicellular organism development [GO:0007275] GO:0004930; GO:0005886; GO:0007275; GO:0016021; GO:0042813 0 0 0 PF01534;PF01392; Q9JIX8 CHOYP_LOC101170959.1.1 m.45714 sp ACINU_MOUSE 40.233 430 188 13 622 1021 844 1234 1.51E-61 233 ACINU_MOUSE reviewed Apoptotic chromatin condensation inducer in the nucleus (Acinus) Acin1 Acinus Mus musculus (Mouse) 1338 "apoptotic chromosome condensation [GO:0030263]; apoptotic process [GO:0006915]; erythrocyte differentiation [GO:0030218]; mitophagy in response to mitochondrial depolarization [GO:0098779]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of monocyte differentiation [GO:0045657]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]; xenophagy [GO:0098792]" GO:0000166; GO:0002230; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005886; GO:0006397; GO:0006915; GO:0008380; GO:0016607; GO:0030218; GO:0030263; GO:0035145; GO:0042981; GO:0043065; GO:0044822; GO:0045657; GO:0048025; GO:0061574; GO:0098779; GO:0098792 0 0 0 PF16294;PF02037; Q9NXG6 CHOYP_BRAFLDRAFT_126352.2.2 m.64882 sp P4HTM_HUMAN 31.429 420 249 11 8 397 70 480 1.51E-59 204 P4HTM_HUMAN reviewed Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) P4HTM PH4 Homo sapiens (Human) 502 regulation of erythrocyte differentiation [GO:0045646] GO:0005506; GO:0005509; GO:0005789; GO:0016021; GO:0016706; GO:0031418; GO:0045646 0 0 0 PF13640;PF13499; Q9R1R2 CHOYP_BRAFLDRAFT_87327.6.13 m.39252 sp TRIM3_MOUSE 26.829 123 85 3 142 260 622 743 1.51E-07 55.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9VAC5 CHOYP_ADA17.2.3 m.15441 sp ADA17_DROME 35.978 731 422 20 5 713 16 722 1.51E-140 432 ADA17_DROME reviewed ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) 732 membrane protein ectodomain proteolysis [GO:0006509] GO:0004222; GO:0006509; GO:0008270; GO:0016021 0 0 0 PF16698;PF00200;PF01562; Q9VZF4 CHOYP_LOC756678.1.2 m.37263 sp FBXW7_DROME 29.268 287 194 4 848 1128 982 1265 1.51E-41 170 FBXW7_DROME reviewed F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) ago CG15010 Drosophila melanogaster (Fruit fly) 1326 "axon guidance [GO:0007411]; branch fusion, open tracheal system [GO:0035147]; cellular response to hypoxia [GO:0071456]; DNA endoreduplication [GO:0042023]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of growth [GO:0045926]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of mitophagy [GO:1903146]; regulation of mitotic nuclear division [GO:0007088]; regulation of proteolysis [GO:0030162]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; trachea development [GO:0060438]; ventral cord development [GO:0007419]" GO:0005634; GO:0007088; GO:0007096; GO:0007411; GO:0007419; GO:0008054; GO:0016567; GO:0019005; GO:0030162; GO:0030332; GO:0031146; GO:0035147; GO:0042023; GO:0045926; GO:0060253; GO:0060438; GO:0071456; GO:1900038; GO:1903146 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9W735 CHOYP_LOC100374504.1.2 m.27883 sp PRM1A_DANRE 27.341 801 556 14 36 818 34 826 1.51E-102 339 PRM1A_DANRE reviewed Prominin-1-A (Prominin-like protein 1) prom1a proml1 Danio rerio (Zebrafish) (Brachydanio rerio) 826 0 GO:0005783; GO:0005793; GO:0005886; GO:0016021; GO:0016324; GO:0031528 0 0 0 PF05478; Q9Y3Z3 CHOYP_SAMH1.9.12 m.47435 sp SAMH1_HUMAN 51.441 451 209 7 4 445 116 565 1.51E-153 452 SAMH1_HUMAN reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) SAMHD1 MOP5 Homo sapiens (Human) 626 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; immune response [GO:0006955]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; type I interferon signaling pathway [GO:0060337] GO:0003676; GO:0003723; GO:0005622; GO:0005634; GO:0005654; GO:0005886; GO:0006203; GO:0006955; GO:0008270; GO:0008832; GO:0032567; GO:0045088; GO:0046061; GO:0051289; GO:0051607; GO:0060337 0 0 0 PF01966;PF07647; Q9Y6R4 CHOYP_LOC592876.1.1 m.15660 sp M3K4_HUMAN 38.356 146 85 3 13 157 863 1004 1.51E-18 84.7 M3K4_HUMAN reviewed Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) MAP3K4 KIAA0213 MAPKKK4 MEKK4 MTK1 Homo sapiens (Human) 1608 activation of MAPKK activity [GO:0000186]; chorionic trophoblast cell differentiation [GO:0060718]; intracellular signal transduction [GO:0035556]; male germ-line sex determination [GO:0019100]; placenta development [GO:0001890]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of gene expression [GO:0010468]; response to UV-C [GO:0010225] GO:0000186; GO:0001890; GO:0004709; GO:0005524; GO:0005737; GO:0010225; GO:0010468; GO:0019100; GO:0032212; GO:0035556; GO:0043507; GO:0046872; GO:0048471; GO:0051973; GO:0060718; GO:1900745; GO:1904355 0 0 0 PF00069; A2AJ76 CHOYP_CNTN5.4.5 m.44639 sp HMCN2_MOUSE 23.134 536 322 25 37 517 2265 2765 1.52E-12 75.5 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A2AVA0 CHOYP_LYAM3.4.4 m.6000 sp SVEP1_MOUSE 29.904 311 199 6 138 448 2765 3056 1.52E-35 147 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A3RLT6 CHOYP_RSSA.10.10 m.65718 sp RSSA_PINFU 83.276 293 44 5 1 291 1 290 1.52E-164 462 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A4FU69 CHOYP_NEMVEDRAFT_V1G167853.2.2 m.50027 sp EFCB5_HUMAN 40.501 679 374 9 452 1105 805 1478 1.52E-165 531 EFCB5_HUMAN reviewed EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) 1503 0 GO:0005509 0 0 0 0 A5D7H5 CHOYP_YL58.1.1 m.35411 sp CASC3_BOVIN 40.102 197 99 3 42 221 68 262 1.52E-28 127 CASC3_BOVIN reviewed Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein homolog) (MLN 51 homolog) (Protein barentsz) (Btz) CASC3 MLN51 Bos taurus (Bovine) 703 "intracellular mRNA localization [GO:0008298]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA splicing [GO:0008380]" GO:0000184; GO:0006397; GO:0006417; GO:0008298; GO:0008380; GO:0016070; GO:0016607; GO:0030529; GO:0035145; GO:0044822; GO:0048471; GO:0051028 0 0 0 PF09405; A6PWD2 CHOYP_BRAFLDRAFT_127466.1.1 m.62415 sp FHAD1_MOUSE 27.572 1429 819 46 1 1298 1 1344 1.52E-106 373 FHAD1_MOUSE reviewed Forkhead-associated domain-containing protein 1 (FHA domain-containing protein 1) Fhad1 Mus musculus (Mouse) 1420 0 0 0 0 0 PF00498; O00338 CHOYP_LOC100459096.3.3 m.45135 sp ST1C2_HUMAN 34.981 263 143 9 31 269 30 288 1.52E-41 147 ST1C2_HUMAN reviewed Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.-) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2) SULT1C2 SULT1C1 Homo sapiens (Human) 296 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; sulfation [GO:0051923] GO:0004062; GO:0005737; GO:0005829; GO:0008146; GO:0009308; GO:0050427; GO:0051923; GO:0070062 0 0 0 PF00685; O35600 CHOYP_LOC100378128.1.1 m.49394 sp ABCA4_MOUSE 26.515 264 184 4 1 258 1 260 1.52E-25 118 ABCA4_MOUSE reviewed Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) Abca4 Abcr Mus musculus (Mouse) 2310 phospholipid transfer to membrane [GO:0006649]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0001750; GO:0004012; GO:0005524; GO:0005548; GO:0005887; GO:0006649; GO:0007601; GO:0042626; GO:0043231; GO:0045494; GO:0050896 0 0 0 PF00005; O45782 CHOYP_LOC100176335.7.7 m.62981 sp ARD17_CAEEL 32.209 326 201 6 4 315 3 322 1.52E-50 177 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; O75096 CHOYP_LOC100378652.1.1 m.5658 sp LRP4_HUMAN 38.776 147 87 2 11 156 1379 1523 1.52E-26 110 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; O75179 CHOYP_LOC581927.5.27 m.19679 sp ANR17_HUMAN 37.647 425 246 12 4 415 271 689 1.52E-60 216 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O96064 CHOYP_LOC100373653.2.3 m.43046 sp MYSP_MYTGA 75.41 122 30 0 2 123 383 504 1.52E-40 145 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; O96790 CHOYP_TGME49_066610.1.1 m.2678 sp DPGN_DIPMA 37.624 101 34 3 36 107 172 272 1.52E-11 62.8 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P05548 CHOYP_UNC89.9.19 m.35629 sp CAVPT_BRALA 29.299 157 93 6 202 357 103 242 1.52E-06 53.9 CAVPT_BRALA reviewed CAVP-target protein (CAVPT) 0 Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum) 243 0 0 0 0 0 PF07679; P14381 CHOYP_LOC100537145.3.3 m.38392 sp YTX2_XENLA 27.322 183 110 4 16 179 298 476 1.52E-11 65.5 YTX2_XENLA reviewed Transposon TX1 uncharacterized 149 kDa protein (ORF 2) 0 Xenopus laevis (African clawed frog) 1308 0 0 0 0 0 PF03372;PF00078; P16157 CHOYP_TVAG_168010.38.45 m.59938 sp ANK1_HUMAN 34.483 667 424 3 5 662 19 681 1.52E-108 364 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_168010.40.45 m.61138 sp ANK1_HUMAN 34.454 476 312 0 2 477 220 695 1.52E-84 288 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P23772 CHOYP_GATA2.2.2 m.9847 sp GATA3_MOUSE 54.397 307 101 10 48 317 62 366 1.52E-88 280 GATA3_MOUSE reviewed Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) Gata3 Gata-3 Mus musculus (Mouse) 443 "anatomical structure formation involved in morphogenesis [GO:0048646]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cardiac right ventricle morphogenesis [GO:0003215]; cell activation [GO:0001775]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cell morphogenesis [GO:0000902]; cellular response to BMP stimulus [GO:0071773]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-4 [GO:0071353]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; developmental growth [GO:0048589]; digestive tract development [GO:0048565]; ear development [GO:0043583]; embryonic hemopoiesis [GO:0035162]; embryonic organ development [GO:0048568]; erythrocyte differentiation [GO:0030218]; homeostasis of number of cells [GO:0048872]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; inner ear morphogenesis [GO:0042472]; interferon-gamma secretion [GO:0072643]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lymphocyte migration [GO:0072676]; male gonad development [GO:0008584]; mast cell differentiation [GO:0060374]; mesenchymal to epithelial transition [GO:0060231]; mesonephros development [GO:0001823]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell motility [GO:2000146]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell proliferation involved in mesonephros development [GO:2000607]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [GO:2000703]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [GO:2000734]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nephric duct formation [GO:0072179]; nephric duct morphogenesis [GO:0072178]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; norepinephrine biosynthetic process [GO:0042421]; otic vesicle development [GO:0071599]; parathyroid gland development [GO:0060017]; parathyroid hormone secretion [GO:0035898]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-13 secretion [GO:2000667]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-5 secretion [GO:2000664]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of ureteric bud formation [GO:0072107]; post-embryonic development [GO:0009791]; pro-T cell differentiation [GO:0002572]; regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370]; regulation of cellular response to X-ray [GO:2000683]; regulation of cytokine biosynthetic process [GO:0042035]; regulation of establishment of cell polarity [GO:2000114]; regulation of histone H3-K27 methylation [GO:0061085]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; renal system development [GO:0072001]; response to drug [GO:0042493]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to virus [GO:0009615]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell differentiation [GO:0045064]; thymic T cell selection [GO:0045061]; thymus development [GO:0048538]; TOR signaling [GO:0031929]; type IV hypersensitivity [GO:0001806]; ureteric bud formation [GO:0060676]; ureter maturation [GO:0035799]; uterus development [GO:0060065]; ventricular septum development [GO:0003281]" GO:0000122; GO:0000790; GO:0000902; GO:0000976; GO:0000977; GO:0000979; GO:0000987; GO:0001046; GO:0001077; GO:0001078; GO:0001085; GO:0001158; GO:0001701; GO:0001709; GO:0001764; GO:0001775; GO:0001806; GO:0001819; GO:0001822; GO:0001823; GO:0002088; GO:0002572; GO:0003180; GO:0003215; GO:0003281; GO:0003682; GO:0003700; GO:0003713; GO:0005134; GO:0005634; GO:0005667; GO:0005730; GO:0006338; GO:0006357; GO:0006959; GO:0007165; GO:0007399; GO:0007411; GO:0008134; GO:0008270; GO:0008285; GO:0008584; GO:0009615; GO:0009791; GO:0009967; GO:0010332; GO:0010595; GO:0010628; GO:0010629; GO:0010975; GO:0014065; GO:0030182; GO:0030217; GO:0030218; GO:0031929; GO:0032689; GO:0032703; GO:0032736; GO:0032753; GO:0032754; GO:0033077; GO:0033600; GO:0035162; GO:0035457; GO:0035799; GO:0035898; GO:0042035; GO:0042421; GO:0042472; GO:0042493; GO:0043370; GO:0043523; GO:0043565; GO:0043583; GO:0043627; GO:0044212; GO:0045061; GO:0045064; GO:0045087; GO:0045471; GO:0045582; GO:0045597; GO:0045599; GO:0045786; GO:0045892; GO:0045893; GO:0045944; GO:0046983; GO:0048469; GO:0048485; GO:0048538; GO:0048565; GO:0048568; GO:0048589; GO:0048646; GO:0048872; GO:0050728; GO:0050852; GO:0051569; GO:0051897; GO:0060017; GO:0060037; GO:0060065; GO:0060231; GO:0060374; GO:0060676; GO:0061085; GO:0061290; GO:0070888; GO:0071345; GO:0071353; GO:0071356; GO:0071442; GO:0071599; GO:0071773; GO:0071837; GO:0072001; GO:0072107; GO:0072178; GO:0072179; GO:0072182; GO:0072602; GO:0072643; GO:0072676; GO:1901536; GO:2000114; GO:2000146; GO:2000352; GO:2000553; GO:2000607; GO:2000611; GO:2000617; GO:2000664; GO:2000667; GO:2000679; GO:2000683; GO:2000703; GO:2000734 0 0 0 PF00320; P27398 CHOYP_LOC100165317.1.1 m.8504 sp CAND_DROME 28.531 701 425 23 93 755 931 1593 1.52E-76 273 CAND_DROME reviewed Calpain-D (EC 3.4.22.-) (Calcium-activated neutral proteinase D) (CANP D) (Small optic lobes protein) sol CalpD CG1391 Drosophila melanogaster (Fruit fly) 1594 nervous system development [GO:0007399]; proteolysis [GO:0006508]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0004198; GO:0005622; GO:0005737; GO:0006508; GO:0007399; GO:0007601; GO:0008270; GO:0050896 0 0 0 PF00648;PF00641; P42317 CHOYP_C770_GR4PC0133.1.1 m.64887 sp YXJF_BACSU 36.842 133 80 1 6 134 125 257 1.52E-22 92 YXJF_BACSU reviewed Uncharacterized oxidoreductase YxjF (EC 1.-.-.-) yxjF BSU38970 N15M Bacillus subtilis (strain 168) 257 0 GO:0003858 0 0 0 0 P42325 CHOYP_NCAH.3.5 m.51972 sp NCAH_DROME 69.892 186 56 0 1 186 1 186 1.52E-94 275 NCAH_DROME reviewed Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) 190 0 GO:0005509 0 0 0 PF00036;PF13499; P43146 CHOYP_CNTN1.1.2 m.24316 sp DCC_HUMAN 33.333 177 100 8 27 199 247 409 1.52E-11 69.3 DCC_HUMAN reviewed Netrin receptor DCC (Colorectal cancer suppressor) (Immunoglobulin superfamily DCC subclass member 1) (Tumor suppressor protein DCC) DCC IGDCC1 Homo sapiens (Human) 1447 anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; dorsal/ventral axon guidance [GO:0033563]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of neuron projection development [GO:0010977]; neuron migration [GO:0001764]; regulation of neuron death [GO:1901214]; spinal cord ventral commissure morphogenesis [GO:0021965] GO:0001764; GO:0004888; GO:0005042; GO:0005829; GO:0005886; GO:0006915; GO:0007409; GO:0007411; GO:0010977; GO:0016021; GO:0021965; GO:0030424; GO:0033563; GO:0033564; GO:0048671; GO:0097192; GO:1901214; GO:2000171 0 0 0 PF00041;PF07679;PF06583; P61208 CHOYP_LOC100656898.1.1 m.56549 sp ARL4C_MOUSE 55.191 183 81 1 1 182 8 190 1.52E-67 207 ARL4C_MOUSE reviewed ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like 7) Arl4c Arl7 Mus musculus (Mouse) 192 endocytic recycling [GO:0032456]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0005886; GO:0007264; GO:0030175; GO:0032456; GO:0043014 0 0 0 PF00025; Q03145 CHOYP_RYK.1.1 m.4142 sp EPHA2_MOUSE 37.262 263 146 7 11 265 616 867 1.52E-49 187 EPHA2_MOUSE reviewed Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2) Epha2 Eck Myk2 Sek2 Mus musculus (Mouse) 977 activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel morphogenesis [GO:0048514]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production [GO:0001818]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of protein kinase B signaling [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; post-anal tail morphogenesis [GO:0036342]; protein kinase B signaling [GO:0043491]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570] GO:0001501; GO:0001568; GO:0001570; GO:0001649; GO:0001818; GO:0002043; GO:0004714; GO:0005003; GO:0005524; GO:0005622; GO:0005886; GO:0005887; GO:0005925; GO:0006954; GO:0007155; GO:0008630; GO:0009986; GO:0010591; GO:0014028; GO:0016477; GO:0016525; GO:0021915; GO:0030182; GO:0030216; GO:0030316; GO:0031256; GO:0031258; GO:0032587; GO:0032682; GO:0033598; GO:0033628; GO:0036342; GO:0043491; GO:0043535; GO:0045765; GO:0046849; GO:0048013; GO:0048320; GO:0048514; GO:0048570; GO:0050830; GO:0051898; GO:0060035; GO:0060326; GO:0060444; GO:0070309; GO:0070372; GO:0070848; GO:0090004; GO:0090630; GO:1901491; GO:1904238 0 0 0 PF14575;PF01404;PF00041;PF07714;PF00536; Q08E40 CHOYP_LOC100367064.1.1 m.52280 sp S39AC_BOVIN 33.469 493 277 12 310 789 200 654 1.52E-79 271 S39AC_BOVIN reviewed Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) SLC39A12 ZIP12 Bos taurus (Bovine) 654 cellular zinc ion homeostasis [GO:0006882]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; signal transduction [GO:0007165]; zinc II ion transmembrane import [GO:0071578] GO:0005385; GO:0005887; GO:0006882; GO:0007165; GO:0010975; GO:0031113; GO:0048471; GO:0071578; GO:1903561 0 0 0 PF02535; Q14162 CHOYP_MEGF11.8.11 m.52056 sp SREC_HUMAN 34.058 276 152 12 184 442 153 415 1.52E-34 144 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q20191 CHOYP_PTN11.4.4 m.62828 sp NAS13_CAEEL 32.938 337 204 7 92 410 118 450 1.52E-51 183 NAS13_CAEEL reviewed Zinc metalloproteinase nas-13 (EC 3.4.24.21) (Nematode astacin 13) nas-13 F39D8.4 Caenorhabditis elegans 450 0 GO:0004222; GO:0005576; GO:0008270 0 0 0 PF01400;PF01549; Q24372 CHOYP_LOC100121356.1.1 m.1164 sp LACH_DROME 24.046 262 178 8 24 279 31 277 1.52E-11 68.2 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q2KI15 CHOYP_RF1M.1.1 m.17614 sp RF1ML_BOVIN 46.203 316 166 2 112 426 64 376 1.52E-94 292 RF1ML_BOVIN reviewed "Peptide chain release factor 1-like, mitochondrial (Mitochondrial translational release factor 1-like)" MTRF1L Bos taurus (Bovine) 380 mitochondrial translational termination [GO:0070126] GO:0005739; GO:0016149; GO:0043022; GO:0070126 0 0 0 PF03462;PF00472; Q3T0L3 CHOYP_PHUM_PHUM229210.1.1 m.50089 sp RM17_BOVIN 32.68 153 94 4 22 172 21 166 1.52E-13 70.1 RM17_BOVIN reviewed "39S ribosomal protein L17, mitochondrial (L17mt) (MRP-L17)" MRPL17 Bos taurus (Bovine) 172 mitochondrial genome maintenance [GO:0000002]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0000002; GO:0003735; GO:0005743; GO:0005762; GO:0070124; GO:0070125 0 0 0 PF01196; Q3TLI0 CHOYP_LOC100122904.1.1 m.45984 sp TPC10_MOUSE 32.082 1119 628 22 2 997 137 1246 1.52E-173 543 TPC10_MOUSE reviewed Trafficking protein particle complex subunit 10 (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1) Trappc10 Tmem1 Mus musculus (Mouse) 1259 early endosome to Golgi transport [GO:0034498]; intra-Golgi vesicle-mediated transport [GO:0006891] GO:0005829; GO:0006891; GO:0034498; GO:1990071 0 0 0 PF12584; Q4ZJM9 CHOYP_C1QL4L.4.7 m.6076 sp C1QL4_MOUSE 28.44 109 70 3 41 147 111 213 1.52E-06 49.3 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q53HV7 CHOYP_NEMVEDRAFT_V1G158158.1.1 m.20853 sp SMUG1_HUMAN 47.863 234 120 2 238 471 27 258 1.52E-73 240 SMUG1_HUMAN reviewed Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-) SMUG1 Homo sapiens (Human) 270 base-excision repair [GO:0006284]; depyrimidination [GO:0045008] GO:0000703; GO:0003677; GO:0004844; GO:0005654; GO:0005730; GO:0006284; GO:0017065; GO:0019104; GO:0045008 0 0 0 PF03167; Q54BU4 CHOYP_BRAFLDRAFT_84327.1.2 m.10077 sp ABCB1_DICDI 57.732 291 121 2 1 289 617 907 1.52E-111 346 ABCB1_DICDI reviewed ABC transporter B family member 1 (ABC transporter ABCB.1) abcB1 mrpA DDB_G0293416 Dictyostelium discoideum (Slime mold) 909 chemotaxis [GO:0006935]; culmination involved in sorocarp development [GO:0031154]; hyperosmotic response [GO:0006972]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005524; GO:0005739; GO:0006810; GO:0006935; GO:0006972; GO:0016021; GO:0031154; GO:0042626; GO:0043190; GO:0055085 0 0 0 PF00664;PF00005; Q5PQM9 CHOYP_KMCP1.1.2 m.5317 sp KMCP1_RAT 60.811 296 103 4 243 536 5 289 1.52E-124 369 KMCP1_RAT reviewed Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) Slc25a30 Kmcp1 Rattus norvegicus (Rat) 291 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q5REC0 CHOYP_ZC21A.2.3 m.53581 sp ZC21A_PONAB 53.488 129 57 2 33 161 78 203 1.52E-31 119 ZC21A_PONAB reviewed Zinc finger C2HC domain-containing protein 1A ZC2HC1A FAM164A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 324 0 GO:0046872 0 0 0 0 Q5XHA1 CHOYP_MD27A.1.2 m.18338 sp MED27_XENTR 40.127 314 181 4 1 310 1 311 1.52E-80 249 MED27_XENTR reviewed Mediator of RNA polymerase II transcription subunit 27 (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Mediator complex subunit 27) med27 crsp8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 311 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11571; Q6DG99 CHOYP_KCTD6.1.1 m.15203 sp KCTD6_DANRE 35.61 205 127 3 4 204 11 214 1.52E-36 131 KCTD6_DANRE reviewed BTB/POZ domain-containing protein KCTD6 kctd6 zgc:91884 Danio rerio (Zebrafish) (Brachydanio rerio) 237 protein homooligomerization [GO:0051260] GO:0051260 0 0 0 PF02214; Q6DIB5 CHOYP_MEG10.27.91 m.33834 sp MEG10_MOUSE 37.426 505 272 23 3 493 298 772 1.52E-69 244 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6NXP6 CHOYP_LOC100375012.1.1 m.11931 sp NXRD1_HUMAN 34.104 346 210 5 32 364 1 341 1.52E-57 194 NXRD1_HUMAN reviewed NADP-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) (Pyrroline-5-carboxylate reductase-like protein C14orf148) NOXRED1 C14orf148 Homo sapiens (Human) 359 proline biosynthetic process [GO:0006561] GO:0004735; GO:0006561 0 0 0 PF03807; Q6PFX9 CHOYP_BRAFLDRAFT_126480.1.1 m.31307 sp TNKS1_MOUSE 28.804 184 91 11 265 427 1139 1303 1.52E-06 55.5 TNKS1_MOUSE reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) 1320 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; Q6TMK8 CHOYP_LOC100375640.1.1 m.21617 sp PLD3B_CRIGR 48.824 170 87 0 1 170 1 170 1.52E-55 178 PLD3B_CRIGR reviewed PRELI domain containing protein 3B (BCR/ABL-regulated protein) (Protein slowmo homolog 2) PRELID3B C20orf45 SLMO2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 195 0 0 0 0 0 PF04707; Q791V5 CHOYP_BRAFLDRAFT_268591.1.1 m.59745 sp MTCH2_MOUSE 46.667 165 83 1 49 208 123 287 1.52E-47 162 MTCH2_MOUSE reviewed Mitochondrial carrier homolog 2 Mtch2 Mus musculus (Mouse) 303 hepatocyte apoptotic process [GO:0097284]; positive regulation of apoptotic process [GO:0043065]; protein localization to mitochondrion [GO:0070585]; regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108] GO:0005634; GO:0005739; GO:0005741; GO:0005743; GO:0016020; GO:0016021; GO:0043065; GO:0070062; GO:0070585; GO:0097284; GO:1902108 0 0 0 PF00153; Q8C1Z8 CHOYP_LOC100123238.1.1 m.27155 sp TM10A_MOUSE 40.956 293 162 8 11 296 24 312 1.52E-64 210 TM10A_MOUSE reviewed tRNA methyltransferase 10 homolog A (EC 2.1.1.-) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) Trmt10a Rg9mtd2 Mus musculus (Mouse) 328 magnesium ion homeostasis [GO:0010960]; tRNA methylation [GO:0030488] GO:0000049; GO:0005634; GO:0005730; GO:0008168; GO:0010960; GO:0030488; GO:0044822; GO:0070062 0 0 0 PF01746; Q8IV01 CHOYP_SYT12.1.1 m.59346 sp SYT12_HUMAN 40.196 306 179 3 113 415 116 420 1.52E-75 244 SYT12_HUMAN reviewed Synaptotagmin-12 (Synaptotagmin XII) (SytXII) SYT12 Homo sapiens (Human) 421 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; long-term synaptic potentiation [GO:0060291]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of neurotransmitter secretion [GO:0046928]; spontaneous exocytosis of neurotransmitter [GO:0048792]; synaptic vesicle endocytosis [GO:0048488]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019905; GO:0030054; GO:0030276; GO:0030672; GO:0046928; GO:0048488; GO:0048791; GO:0048792; GO:0060291 0 0 0 PF00168; Q8IV35 CHOYP_LOC100890041.1.1 m.36694 sp WDR49_HUMAN 30.983 539 343 11 427 964 16 526 1.52E-76 271 WDR49_HUMAN reviewed WD repeat-containing protein 49 WDR49 Homo sapiens (Human) 697 0 0 0 0 0 PF00400; Q8MJJ7 CHOYP_DCPS.1.1 m.11760 sp DCPS_BOVIN 55.705 149 66 0 12 160 103 251 1.52E-57 186 DCPS_BOVIN reviewed m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) DCPS DCS1 HINT5 Bos taurus (Bovine) 337 "cellular response to menadione [GO:0036245]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA cis splicing, via spliceosome [GO:0045292]; negative regulation of programmed cell death [GO:0043069]" GO:0000290; GO:0000340; GO:0005634; GO:0005737; GO:0036245; GO:0043069; GO:0045292; GO:0050072 0 0 0 PF05652; Q8NFH5 CHOYP_LOC101064384.1.1 m.19175 sp NUP53_HUMAN 53.807 197 73 4 25 204 131 326 1.52E-69 218 NUP53_HUMAN reviewed Nucleoporin NUP53 (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44) (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) NUP35 MP44 NUP53 Homo sapiens (Human) 326 "gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of transcription, DNA-templated [GO:0006355]; transmembrane transport [GO:0055085]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083]" GO:0000166; GO:0003697; GO:0005487; GO:0005543; GO:0005635; GO:0005652; GO:0005654; GO:0005886; GO:0006355; GO:0006406; GO:0006409; GO:0006607; GO:0006999; GO:0007077; GO:0010827; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031965; GO:0043231; GO:0044613; GO:0044615; GO:0045111; GO:0055085; GO:0075733; GO:1900034 0 0 0 PF05172; Q95M53 CHOYP_LRIG3.1.3 m.22291 sp TLR2_MACFA 31.944 144 90 4 51 192 45 182 1.52E-07 54.7 TLR2_MACFA reviewed Toll-like receptor 2 (CD antigen CD282) TLR2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 784 cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of inflammatory response [GO:0050729]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 2 signaling pathway [GO:0034134] GO:0002755; GO:0004888; GO:0005794; GO:0006954; GO:0016021; GO:0030670; GO:0034134; GO:0045087; GO:0045121; GO:0050707; GO:0050729; GO:0071726; GO:0071727 0 0 0 PF13855;PF01463;PF01582; Q95RA8 CHOYP_MOB1.1.1 m.19452 sp MOB1_DROME 89.1 211 23 0 1 211 1 211 1.52E-143 402 MOB1_DROME reviewed MOB kinase activator-like 1 (Mob as tumor suppressor protein 1) (Dmob1) (Mps one binder kinase activator-like 1) mats CG13852 Drosophila melanogaster (Fruit fly) 219 apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; chromosome segregation [GO:0007059]; multicellular organism development [GO:0007275]; ovarian follicle cell development [GO:0030707]; signal transduction [GO:0007165] GO:0005634; GO:0005813; GO:0005829; GO:0005886; GO:0006915; GO:0007059; GO:0007165; GO:0007275; GO:0008283; GO:0019901; GO:0030707; GO:0046872 0 0 0 PF03637; Q96MM6 CHOYP_LOC100488894.1.5 m.4048 sp HS12B_HUMAN 30.428 631 349 17 873 1431 61 673 1.52E-78 278 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96RW7 CHOYP_HMCN1.9.44 m.23851 sp HMCN1_HUMAN 22.013 636 401 26 50 616 2561 3170 1.52E-17 91.7 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9GP71 CHOYP_BRAFLDRAFT_71482.1.1 m.56334 sp YELL_DROMD 27.551 294 201 7 6 290 9 299 1.52E-28 124 YELL_DROMD reviewed Protein yellow y Drosophila madeirensis (Fruit fly) 568 male mating behavior [GO:0060179]; melanin biosynthetic process [GO:0042438]; multicellular organism development [GO:0007275] GO:0005576; GO:0007275; GO:0042438; GO:0060179 0 0 0 PF03022; Q9H8W5 CHOYP_BRAFLDRAFT_82868.4.5 m.53117 sp TRI45_HUMAN 24.39 164 107 3 12 166 133 288 1.52E-08 60.1 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9JI18 CHOYP_LRP2.2.7 m.13478 sp LRP1B_MOUSE 30.657 137 73 3 111 231 828 958 1.52E-09 64.3 LRP1B_MOUSE reviewed Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) 4599 in utero embryonic development [GO:0001701] GO:0001701; GO:0005041; GO:0005509; GO:0016020; GO:0016021; GO:0043235; GO:0050750 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q9JLL3 CHOYP_TNR19.2.2 m.57582 sp TNR19_MOUSE 29.851 134 67 7 2 133 10 118 1.52E-06 53.1 TNR19_MOUSE reviewed Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer) Tnfrsf19 Taj Troy Mus musculus (Mouse) 416 hair follicle development [GO:0001942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330] GO:0001942; GO:0004872; GO:0005576; GO:0005886; GO:0016021; GO:0043123; GO:0046330 0 0 0 PF00020; Q9L4Q7 CHOYP_contig_018801 m.22057 sp PROX_CLOSD 35.433 127 77 4 61 183 32 157 1.52E-14 71.2 PROX_CLOSD reviewed Prolyl-tRNA editing protein ProX (Prolyl-tRNA deacylase ProX) proX prdX CLOST_2238 Clostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654) 164 0 GO:0002161; GO:0005737; GO:0043906 0 0 0 PF04073; Q9MYM7 CHOYP_LOC100706023.1.2 m.22582 sp B3GT1_PONPY 40.996 261 148 3 110 369 61 316 1.52E-65 214 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9UGM3 CHOYP_DMBT1.6.34 m.5993 sp DMBT1_HUMAN 59.223 103 38 3 228 329 494 593 1.52E-29 122 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9ULJ7 CHOYP_ASB13A.2.1.1 m.38501 sp ANR50_HUMAN 33.178 214 129 5 25 231 643 849 1.52E-16 83.6 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A1BQQ5 CHOYP_LOC764722.3.3 m.43616 sp MR30_CONMR 35.294 289 141 13 88 356 26 288 1.53E-41 153 MR30_CONMR reviewed Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp isoform 1/2/3) (Mr30-1/2) 0 Conus marmoreus (Marble cone) 289 0 GO:0005576 0 0 0 PF00188; A3KPN8 CHOYP_LOC100028654.1.1 m.62088 sp TTC38_DANRE 49.567 462 233 0 114 575 5 466 1.53E-173 502 TTC38_DANRE reviewed Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 si:ch211-249g22.2 zgc:112407 Danio rerio (Zebrafish) (Brachydanio rerio) 466 0 0 0 0 0 0 A4IF63 CHOYP_contig_029037 m.32969 sp TRIM2_BOVIN 30.435 115 77 2 35 147 631 744 1.53E-08 55.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6QP84 CHOYP_BRAFLDRAFT_282065.1.2 m.589 sp SOAT_BOVIN 22.601 323 224 5 241 550 22 331 1.53E-16 85.1 SOAT_BOVIN reviewed Solute carrier family 10 member 6 (Sodium-dependent organic anion transporter) SLC10A6 SOAT Bos taurus (Bovine) 377 sodium-dependent organic anion transport [GO:0043251] GO:0005887; GO:0008508; GO:0043250; GO:0043251 0 0 0 PF01758; A7SLZ2 CHOYP_LOC101160004.1.1 m.48946 sp STING_NEMVE 31.757 148 93 4 170 310 193 339 1.53E-09 63.9 STING_NEMVE reviewed Stimulator of interferon genes protein (STING) v1g246111 Nematostella vectensis (Starlet sea anemone) 377 activation of innate immune response [GO:0002218]; positive regulation of type I interferon production [GO:0032481] GO:0002218; GO:0005789; GO:0016021; GO:0032481; GO:0035438; GO:0061507 0 0 0 PF15009; E7FAM5 CHOYP_LOC100749764.2.2 m.63434 sp LIN41_DANRE 24.936 389 231 12 21 359 59 436 1.53E-23 110 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; G5EBR3 CHOYP_S12A2.2.2 m.39395 sp GLUCL_CAEEL 24.359 390 270 10 18 396 79 454 1.53E-32 130 GLUCL_CAEEL reviewed Glutamate-gated chloride channel alpha (Avermectin-sensitive glutamate-gated chloride channel GluCl alpha) (GluCl alpha) glc-1 F11A5.10 Caenorhabditis elegans 461 chloride transmembrane transport [GO:1902476]; locomotion involved in locomotory behavior [GO:0031987]; protein oligomerization [GO:0051259] GO:0005887; GO:0008068; GO:0016595; GO:0030054; GO:0031987; GO:0045211; GO:0051259; GO:1902476 0 0 0 PF02931;PF02932; I3LM39 CHOYP_MB21D1.4.5 m.55109 sp CGAS_PIG 25.328 458 301 18 138 571 26 466 1.53E-22 104 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O14901 CHOYP_KLF5.1.1 m.5917 sp KLF11_HUMAN 66.667 117 38 1 227 343 364 479 1.53E-47 171 KLF11_HUMAN reviewed Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2) KLF11 FKLF TIEG2 Homo sapiens (Human) 512 apoptotic process [GO:0006915]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000083; GO:0000122; GO:0000981; GO:0003700; GO:0005634; GO:0006366; GO:0006915; GO:0008285; GO:0043065; GO:0044212; GO:0046872 0 0 0 PF00096; O43827 CHOYP_BRAFLDRAFT_125263.7.9 m.58993 sp ANGL7_HUMAN 34.796 319 177 10 67 370 39 341 1.53E-53 183 ANGL7_HUMAN reviewed Angiopoietin-related protein 7 (Angiopoietin-like factor) (Angiopoietin-like protein 7) (Cornea-derived transcript 6 protein) ANGPTL7 CDT6 UNQ313/PRO356 Homo sapiens (Human) 346 response to oxidative stress [GO:0006979] GO:0005576; GO:0006979 0 0 0 PF00147; O54874 CHOYP_SI_CH211-89P3.3.1.1 m.6015 sp MRCKA_RAT 42.616 237 123 4 3 228 1362 1596 1.53E-53 194 MRCKA_RAT reviewed Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha) Cdc42bpa Pk428 Rattus norvegicus (Rat) 1732 actin cytoskeleton reorganization [GO:0031532]; actomyosin structure organization [GO:0031032]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0000287; GO:0004674; GO:0005524; GO:0005737; GO:0005911; GO:0006468; GO:0007010; GO:0016477; GO:0031032; GO:0031252; GO:0031532; GO:0035556; GO:0042641; GO:0042802; GO:0051056 0 0 0 PF00130;PF00780;PF08826;PF15796;PF00069;PF00433; O75179 CHOYP_LOC583072.6.25 m.33001 sp ANR17_HUMAN 30.755 530 288 19 793 1307 236 701 1.53E-36 155 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_BRAFLDRAFT_69765.17.23 m.57988 sp TRIM3_HUMAN 29.688 128 82 4 144 265 619 744 1.53E-07 55.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88801 CHOYP_LOC100313636.2.3 m.26350 sp HOME2_RAT 41.058 397 182 6 13 404 1 350 1.53E-91 283 HOME2_RAT reviewed Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2) Homer2 Vesl2 Rattus norvegicus (Rat) 354 sensory perception of sound [GO:0007605] GO:0005730; GO:0005737; GO:0007605; GO:0014069; GO:0019904; GO:0030054; GO:0030425; GO:0032426; GO:0035254; GO:0035256; GO:0042803; GO:0043025; GO:0045211; GO:0046982 0 0 0 PF00568; P02460 CHOYP_CO2A1.1.1 m.62997 sp CO2A1_CHICK 37.657 239 137 4 66 294 132 368 1.53E-50 173 CO2A1_CHICK reviewed Collagen alpha-1(II) chain (Alpha-1 type II collagen) (Fragment) COL2A1 Gallus gallus (Chicken) 369 cartilage condensation [GO:0001502]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to BMP stimulus [GO:0071773]; central nervous system development [GO:0007417]; chondrocyte differentiation [GO:0002062]; collagen fibril organization [GO:0030199]; embryonic skeletal joint morphogenesis [GO:0060272]; endochondral ossification [GO:0001958]; heart morphogenesis [GO:0003007]; inner ear morphogenesis [GO:0042472]; limb bud formation [GO:0060174]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; notochord development [GO:0030903]; otic vesicle development [GO:0071599]; palate development [GO:0060021]; proteoglycan metabolic process [GO:0006029]; regulation of gene expression [GO:0010468]; sensory perception of sound [GO:0007605]; tissue homeostasis [GO:0001894]; visual perception [GO:0007601] GO:0001502; GO:0001894; GO:0001958; GO:0002062; GO:0003007; GO:0005201; GO:0005585; GO:0005604; GO:0005615; GO:0005737; GO:0006029; GO:0007417; GO:0007601; GO:0007605; GO:0010468; GO:0030199; GO:0030903; GO:0042472; GO:0046872; GO:0060021; GO:0060174; GO:0060272; GO:0060351; GO:0071599; GO:0071773; GO:2001240 0 0 0 PF01410;PF01391; P05300 CHOYP_LAMP1.3.3 m.16600 sp LAMP1_CHICK 28.645 391 198 17 336 688 67 414 1.53E-23 107 LAMP1_CHICK reviewed Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (Lysosome membrane glycoprotein LEP100) LAMP1 Gallus gallus (Chicken) 414 0 GO:0005765; GO:0005770; GO:0005886; GO:0010008; GO:0016020; GO:0016021 0 0 0 PF01299; P08548 CHOYP_LOC100371228.3.4 m.34508 sp LIN1_NYCCO 24.729 554 408 4 1 548 278 828 1.53E-50 190 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P16068 CHOYP_GCYB1.1.1 m.56138 sp GCYB1_BOVIN 30.404 421 259 7 1 409 1 399 1.53E-60 209 GCYB1_BOVIN reviewed Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) GUCY1B1 GUC1B3 GUCY1B3 Bos taurus (Bovine) 619 cellular response to nitric oxide [GO:0071732]; cGMP biosynthetic process [GO:0006182]; nitric oxide-cGMP-mediated signaling pathway [GO:0038060] GO:0004383; GO:0005525; GO:0005737; GO:0005886; GO:0006182; GO:0008074; GO:0020037; GO:0038060; GO:0046872; GO:0071732 0 0 0 PF00211;PF07700;PF07701; P23978 CHOYP_SC6A1.1.1 m.36548 sp SC6A1_RAT 39.64 222 120 3 33 242 14 233 1.53E-53 185 SC6A1_RAT reviewed Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) Slc6a1 Gabt1 Gat-1 Gat1 Rattus norvegicus (Rat) 599 "gamma-aminobutyric acid import [GO:0051939]; learning [GO:0007612]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neurotransmitter transport [GO:0006836]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; protein homooligomerization [GO:0051260]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; response to organonitrogen compound [GO:0010243]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]" GO:0005328; GO:0005332; GO:0005886; GO:0005887; GO:0006836; GO:0007612; GO:0009636; GO:0009744; GO:0009986; GO:0010033; GO:0010243; GO:0010288; GO:0014054; GO:0014070; GO:0014074; GO:0030424; GO:0032229; GO:0032355; GO:0042220; GO:0043005; GO:0046872; GO:0051260; GO:0051592; GO:0051939; GO:0098779 0 0 0 PF00209; P24668 CHOYP_LOC100863962.2.2 m.47976 sp MPRD_MOUSE 33.858 127 80 2 127 249 120 246 1.53E-14 74.7 MPRD_MOUSE reviewed Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6pr 46mpr Mus musculus (Mouse) 278 intracellular protein transport [GO:0006886]; secretion of lysosomal enzymes [GO:0033299] GO:0005537; GO:0005765; GO:0005768; GO:0005770; GO:0005802; GO:0006886; GO:0015578; GO:0016020; GO:0016021; GO:0033299; GO:0048471 0 0 0 PF02157; P29597 CHOYP_MONBRDRAFT_44336.1.2 m.16315 sp TYK2_HUMAN 29.983 587 327 23 203 757 632 1166 1.53E-56 213 TYK2_HUMAN reviewed Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) TYK2 Homo sapiens (Human) 1187 cell differentiation [GO:0030154]; cell migration [GO:0016477]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; peptidyl-tyrosine autophosphorylation [GO:0038083]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; type I interferon signaling pathway [GO:0060337] GO:0004713; GO:0004715; GO:0005131; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0006468; GO:0007169; GO:0016477; GO:0030154; GO:0031234; GO:0035556; GO:0038083; GO:0042127; GO:0045087; GO:0060337; GO:0060338; GO:0070062 0 0 0 PF07714; P49756 CHOYP_RBM25.2.2 m.56523 sp RBM25_HUMAN 42.345 307 125 10 1 274 1 288 1.53E-53 189 RBM25_HUMAN reviewed RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) RBM25 RNPC7 Homo sapiens (Human) 843 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003729; GO:0005654; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0016607; GO:0042981; GO:0044822 0 0 0 PF01480;PF00076; P51957 CHOYP_NEK4.3.8 m.31713 sp NEK4_HUMAN 48.062 258 130 4 10 266 10 264 1.53E-71 246 NEK4_HUMAN reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) 841 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; P51989 CHOYP_LOC100748395.4.7 m.40663 sp RO21_XENLA 54.211 190 87 0 58 247 4 193 1.53E-66 218 RO21_XENLA reviewed Heterogeneous nuclear ribonucleoprotein A2 homolog 1 (hnRNP A2(A)) 0 Xenopus laevis (African clawed frog) 346 0 GO:0000166; GO:0003723; GO:0005634; GO:0030529 0 0 0 PF00076; P80513 CHOYP_LOC584368.1.2 m.10628 sp MANF_BOVIN 52.841 176 80 2 8 182 6 179 1.53E-60 189 MANF_BOVIN reviewed Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET) MANF ARMET ARP Bos taurus (Bovine) 179 response to unfolded protein [GO:0006986] GO:0005576; GO:0006986 0 0 0 PF10208; P84175 CHOYP_NEMVEDRAFT_V1G171532.1.2 m.60478 sp RS12_CHICK 80.46 87 14 2 20 105 14 98 1.53E-41 137 RS12_CHICK reviewed 40S ribosomal protein S12 RPS12 Gallus gallus (Chicken) 132 translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0044822 0 0 0 PF01248; Q08B63 CHOYP_L3BPA.1.1 m.26762 sp LOXL2_XENLA 52.885 104 49 0 21 124 46 149 1.53E-31 124 LOXL2_XENLA reviewed Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) loxl2 Xenopus laevis (African clawed frog) 765 "cellular protein modification process [GO:0006464]; collagen fibril organization [GO:0030199]; covalent chromatin modification [GO:0016569]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of chondrocyte differentiation [GO:0032332]; response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; transcription, DNA-templated [GO:0006351]" GO:0001666; GO:0001837; GO:0001935; GO:0002040; GO:0004720; GO:0005044; GO:0005507; GO:0005604; GO:0005615; GO:0005634; GO:0005694; GO:0006351; GO:0006464; GO:0016020; GO:0016569; GO:0030199; GO:0032332; GO:0043542; GO:0045892; GO:0046688; GO:0070492 0 0 0 PF01186;PF00530; Q174D3 CHOYP_LOC100122806.1.1 m.1784 sp MED19_AEDAE 53.052 213 83 4 19 224 10 212 1.53E-60 194 MED19_AEDAE reviewed Mediator of RNA polymerase II transcription subunit 19 (Mediator complex subunit 19) MED19 AAEL006934 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 253 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592 0 0 0 PF10278; Q2M2I8 CHOYP_AAK1.1.1 m.14768 sp AAK1_HUMAN 58.578 408 158 8 18 421 34 434 1.53E-149 480 AAK1_HUMAN reviewed AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) AAK1 KIAA1048 Homo sapiens (Human) 961 endocytosis [GO:0006897]; positive regulation of Notch signaling pathway [GO:0045747]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of clathrin-mediated endocytosis [GO:2000369]; regulation of protein localization [GO:0032880] GO:0004674; GO:0005112; GO:0005524; GO:0005737; GO:0005905; GO:0006468; GO:0006897; GO:0019897; GO:0030136; GO:0031252; GO:0032880; GO:0035612; GO:0043195; GO:0045747; GO:0046777; GO:0050821; GO:2000369 0 0 0 PF00069; Q2TA40 CHOYP_LOC100377601.1.2 m.19061 sp NP1L4_BOVIN 61.351 370 130 5 61 427 27 386 1.53E-136 399 NP1L4_BOVIN reviewed Nucleosome assembly protein 1-like 4 NAP1L4 Bos taurus (Bovine) 386 nucleosome assembly [GO:0006334] GO:0005634; GO:0006334 0 0 0 PF00956; Q3SZZ7 CHOYP_BRAFLDRAFT_68409.1.1 m.39982 sp FGL1_BOVIN 34.421 337 170 8 38 356 1 304 1.53E-50 174 FGL1_BOVIN reviewed Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) 312 0 GO:0070062 0 0 0 PF00147; Q3UIR3 CHOYP_LOC100370943.1.1 m.65345 sp DTX3L_MOUSE 52.577 194 91 1 716 909 555 747 1.53E-54 206 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q460N5 CHOYP_PAR14.17.17 m.65444 sp PAR14_HUMAN 28.138 988 649 25 179 1150 696 1638 1.53E-104 366 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4FZV0 CHOYP_BRAFLDRAFT_65994.1.1 m.40536 sp MANBA_RAT 46.667 165 86 2 12 175 38 201 1.53E-48 171 MANBA_RAT reviewed Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) Manba Rattus norvegicus (Rat) 881 carbohydrate metabolic process [GO:0005975] GO:0004567; GO:0005537; GO:0005764; GO:0005975 PATHWAY: Glycan metabolism; N-glycan degradation. 0 0 PF02836; Q55E58 CHOYP_BRAFLDRAFT_129004.2.15 m.22872 sp PATS1_DICDI 25.413 303 170 12 358 648 1765 2023 1.53E-16 89 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5UQP2 CHOYP_LOC582782.2.4 m.8154 sp YL446_MIMIV 30.256 195 122 6 87 278 55 238 1.53E-17 87.4 YL446_MIMIV reviewed Uncharacterized protein L446 (EC 3.1.1.-) MIMI_L446 Acanthamoeba polyphaga mimivirus (APMV) 332 lipid catabolic process [GO:0016042] GO:0016021; GO:0016042; GO:0016787 0 0 0 PF01734; Q5ZHW4 CHOYP_DANA_GF15280.1.2 m.4538 sp RAB5B_CHICK 55.276 199 75 4 4 202 6 190 1.53E-73 224 RAB5B_CHICK reviewed Ras-related protein Rab-5B RAB5B RCJMB04_32j11 Gallus gallus (Chicken) 215 protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005769; GO:0005886; GO:0007264; GO:0015031; GO:0019003; GO:0030100; GO:0030139; GO:0031901 0 0 0 PF00071; Q6NRS2 CHOYP_LOC100016889.1.1 m.12247 sp PQLC1_XENLA 60.19 211 83 1 84 294 24 233 1.53E-86 262 PQLC1_XENLA reviewed PQ-loop repeat-containing protein 1 pqlc1 Xenopus laevis (African clawed frog) 250 0 GO:0016021 0 0 0 PF04193; Q6NXT6 CHOYP_LOC101434121.1.1 m.55852 sp TAPT1_HUMAN 59.701 201 80 1 3 203 265 464 1.53E-74 244 TAPT1_HUMAN reviewed Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) TAPT1 CMVFR Homo sapiens (Human) 567 cartilage development [GO:0051216]; cell projection organization [GO:0030030]; embryonic skeletal system development [GO:0048706]; in utero embryonic development [GO:0001701]; neural crest cell development [GO:0014032]; ossification [GO:0001503]; positive regulation of bone development [GO:1903012]; positive regulation of cartilage development [GO:0061036]; positive regulation of cilium assembly [GO:0045724]; post-embryonic development [GO:0009791] GO:0001503; GO:0001701; GO:0005737; GO:0005813; GO:0009791; GO:0014032; GO:0016021; GO:0016520; GO:0030030; GO:0036064; GO:0045724; GO:0048706; GO:0051216; GO:0061036; GO:1903012 0 0 0 PF05346; Q6P4M5 CHOYP_BRAFLDRAFT_68464.1.1 m.33253 sp GFOD1_XENTR 47.583 393 199 3 4 394 1 388 1.53E-133 390 GFOD1_XENTR reviewed Glucose-fructose oxidoreductase domain-containing protein 1 (EC 1.-.-.-) gfod1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 390 oxidation-reduction process [GO:0055114] GO:0005576; GO:0016491; GO:0055114 0 0 0 PF01408; Q6ZRF8 CHOYP_LOC100376025.1.1 m.47307 sp RN207_HUMAN 22.363 237 167 6 17 248 103 327 1.53E-08 58.5 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q71R50 CHOYP_DHRS11A.1.1 m.28891 sp DHR11_CHICK 57.708 253 104 2 1 250 1 253 1.53E-102 301 DHR11_CHICK reviewed Dehydrogenase/reductase SDR family member 11 (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 24C member 1) DHRS11 SDR24C1 Gallus gallus (Chicken) 255 0 GO:0005576; GO:0016491 0 0 0 PF00106; Q7TSU0 CHOYP_C1D.1.1 m.25464 sp C1D_CRIGR 43.885 139 78 0 17 155 1 139 1.53E-39 134 C1D_CRIGR reviewed Nuclear nucleic acid-binding protein C1D C1D Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 141 "apoptotic process [GO:0006915]; regulation of transcription, DNA-templated [GO:0006355]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0006364; GO:0006915 0 0 0 PF04000; Q8BZ25 CHOYP_AASI_1435.1.35 m.14040 sp ANKK1_MOUSE 33.99 203 118 3 28 230 373 559 1.53E-26 110 ANKK1_MOUSE reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) 745 0 GO:0004674; GO:0005524 0 0 0 PF00023;PF12796;PF07714; Q8K2J9 CHOYP_BTBD6.1.6 m.16684 sp BTBD6_MOUSE 31.75 400 250 7 24 408 64 455 1.53E-57 199 BTBD6_MOUSE reviewed BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) 488 0 GO:0000932 0 0 0 PF07707;PF00651;PF08005; Q8N413 CHOYP_S2545.2.2 m.55067 sp S2545_HUMAN 42.759 290 153 6 28 310 3 286 1.53E-74 233 S2545_HUMAN reviewed Solute carrier family 25 member 45 SLC25A45 Homo sapiens (Human) 288 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q8NFZ3 CHOYP_NLGN4.3.4 m.1674 sp NLGNY_HUMAN 31.627 762 437 21 49 779 63 771 1.53E-103 342 NLGNY_HUMAN reviewed "Neuroligin-4, Y-linked (Neuroligin Y)" NLGN4Y KIAA0951 Homo sapiens (Human) 816 learning [GO:0007612]; modulation of synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] GO:0004872; GO:0005887; GO:0007158; GO:0007416; GO:0007612; GO:0009986; GO:0014069; GO:0030054; GO:0035176; GO:0042043; GO:0045202; GO:0045211; GO:0050804; GO:0050839; GO:0052689; GO:0071625; GO:0097110 0 0 0 PF00135; Q8VE97 CHOYP_SRSF4.3.6 m.13799 sp SRSF4_MOUSE 81.481 54 10 0 1 54 124 177 1.53E-25 101 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q8WPW2 CHOYP_NEMVEDRAFT_V1G194582.2.2 m.40727 sp PDX1_SUBDO 74.545 275 70 0 25 299 13 287 1.53E-152 433 PDX1_SUBDO reviewed Pyridoxal 5'-phosphate synthase subunit SNZERR (PLP synthase subunit SNZERR) (EC 4.3.3.6) (Ethylene response protein) (PDX1) SNZERR ERR Suberites domuncula (Sponge) 306 pyridoxal phosphate biosynthetic process [GO:0042823]; vitamin B6 biosynthetic process [GO:0042819] GO:0036381; GO:0042819; GO:0042823 PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. 0 cd04727; 0 Q92038 CHOYP_ACOD.2.8 m.14489 sp ACOD_CYPCA 74.566 173 44 0 2 174 109 281 1.53E-95 283 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; Q921X6 CHOYP_RPC6.2.2 m.51638 sp RPC6_MOUSE 71.861 231 65 0 41 271 22 252 1.53E-120 350 RPC6_MOUSE reviewed DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) Polr3f Mus musculus (Mouse) 316 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription from RNA polymerase III promoter [GO:0006359]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003899; GO:0005666; GO:0006359; GO:0006383; GO:0032728; GO:0045087; GO:0045089; GO:0051607 0 0 0 PF05158; Q96LR7 CHOYP_LOC100374147.1.2 m.8741 sp CB050_HUMAN 32.71 107 72 0 36 142 53 159 1.53E-17 77.4 CB050_HUMAN reviewed Uncharacterized protein C2orf50 C2orf50 Homo sapiens (Human) 162 0 0 0 0 0 0 Q99NH0 CHOYP_AASI_1435.20.35 m.45200 sp ANR17_MOUSE 40.152 132 78 1 1 131 1076 1207 1.53E-17 80.9 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BXW7 CHOYP_LOC100183583.1.2 m.3863 sp CECR5_HUMAN 40.657 396 212 8 37 424 43 423 1.53E-95 296 CECR5_HUMAN reviewed Cat eye syndrome critical region protein 5 CECR5 Homo sapiens (Human) 423 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q9ESN6 CHOYP_LOC100213744.19.19 m.60498 sp TRIM2_MOUSE 25.373 268 173 12 336 588 489 744 1.53E-11 70.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NFP5 CHOYP_SH3L1.4.5 m.46235 sp SH3BG_DROME 43.59 117 56 3 1 108 1 116 1.53E-24 100 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9NWW9 CHOYP_BRAFLDRAFT_119296.15.16 m.64264 sp HRSL2_HUMAN 41.86 129 71 3 17 145 10 134 1.53E-24 96.3 HRSL2_HUMAN reviewed HRAS-like suppressor 2 (EC 2.3.1.-) (EC 3.1.1.-) HRASLS2 Homo sapiens (Human) 162 lipid catabolic process [GO:0016042] GO:0005737; GO:0016021; GO:0016042; GO:0016746; GO:0016787 0 0 0 PF04970; Q9NX08 CHOYP_LOC584270.1.1 m.49225 sp COMD8_HUMAN 40 180 106 1 6 183 4 183 1.53E-42 143 COMD8_HUMAN reviewed COMM domain-containing protein 8 COMMD8 MDS022 Homo sapiens (Human) 183 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355 0 0 0 PF07258; Q9P2E3 CHOYP_ZNFX1.1.12 m.4698 sp ZNFX1_HUMAN 30.348 402 234 11 1 382 387 762 1.53E-47 180 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9U489 CHOYP_BRAFLDRAFT_87319.4.5 m.41985 sp LIN41_CAEEL 25.862 174 102 5 125 285 847 1006 1.53E-07 56.2 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9VWQ2 CHOYP_LOC100858674.1.1 m.13610 sp S6KL_DROME 37.151 358 191 8 30 361 109 458 1.53E-70 231 S6KL_DROME reviewed Serine/threonine-protein kinase S6KL (EC 2.7.11.-) (Protein kinase-like 17E) (S6 kinase-like protein) S6KL Bin4 Pk17E CG7001 Drosophila melanogaster (Fruit fly) 483 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0035556 0 0 0 PF00069; A2AX52 CHOYP_BRAFLDRAFT_90333.1.1 m.51612 sp CO6A4_MOUSE 24.339 189 123 7 21 207 1026 1196 1.54E-07 58.9 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A4QP81 CHOYP_FRRS1.2.3 m.41025 sp FRRS1_DANRE 34.524 168 94 7 6 169 11 166 1.54E-15 77.8 FRRS1_DANRE reviewed Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) 573 0 GO:0016021; GO:0016491 0 0 cd08544; PF03351;PF02014; A5YM72 CHOYP_HSP7D.2.3 m.34786 sp CRNS1_HUMAN 36.257 171 104 4 1 168 24 192 1.54E-22 98.2 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A9CB25 CHOYP_BRAFLDRAFT_75990.1.1 m.49087 sp S22A4_PAPAN 32.228 543 317 9 2 515 3 523 1.54E-88 285 S22A4_PAPAN reviewed Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) SLC22A4 OCTN1 Papio anubis (Olive baboon) 551 carnitine metabolic process [GO:0009437]; sodium ion transport [GO:0006814]; triglyceride metabolic process [GO:0006641] GO:0005524; GO:0005739; GO:0006641; GO:0006814; GO:0009437; GO:0015226; GO:0015293; GO:0015491; GO:0016021; GO:0016324 0 0 cd06174; PF00083; B3EWZ3 CHOYP_LOC101236385.5.6 m.54313 sp CADN_ACRMI 42.892 415 226 4 755 1160 159 571 1.54E-99 352 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; B5FYC7 CHOYP_LYRM1.1.1 m.40098 sp LYRM1_TAEGU 48.739 119 61 0 2 120 4 122 1.54E-36 123 LYRM1_TAEGU reviewed LYR motif-containing protein 1 LYRM1 Taeniopygia guttata (Zebra finch) (Poephila guttata) 122 0 0 0 0 0 PF05347; D2HNW6 CHOYP_RFX6.1.2 m.2754 sp RFX6_AILME 51.515 429 181 6 34 436 42 469 1.54E-143 435 RFX6_AILME reviewed DNA-binding protein RFX6 (Regulatory factor X 6) RFX6 PANDA_013423 Ailuropoda melanoleuca (Giant panda) 928 "endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of insulin secretion [GO:0050796]; type B pancreatic cell differentiation [GO:0003309]" GO:0000977; GO:0001228; GO:0003309; GO:0003310; GO:0003311; GO:0005634; GO:0031018; GO:0035774; GO:0042593; GO:0044212; GO:0045893; GO:0045944; GO:0050796; GO:0090104 0 0 0 PF02257; E9Q6J5 CHOYP_LOC100373080.1.6 m.4852 sp BD1L1_MOUSE 54.808 104 47 0 12 115 50 153 1.54E-33 145 BD1L1_MOUSE reviewed Biorientation of chromosomes in cell division protein 1-like 1 Bod1l Kiaa1327 Mus musculus (Mouse) 3032 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; replication fork processing [GO:0031297] GO:0003677; GO:0005654; GO:0005694; GO:0006281; GO:0006974; GO:0031297 0 0 0 0 O16025 CHOYP_LOC584481.2.10 m.10049 sp AOSL_PLEHO 32.528 704 418 18 4 663 376 1066 1.54E-110 360 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O35186 CHOYP_LOC763308.3.3 m.63145 sp CATK_RAT 50.755 331 155 3 2 328 3 329 1.54E-121 355 CATK_RAT reviewed Cathepsin K (EC 3.4.22.38) Ctsk Rattus norvegicus (Rat) 329 bone resorption [GO:0045453]; collagen catabolic process [GO:0030574]; intramembranous ossification [GO:0001957]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of mitophagy [GO:1903146] GO:0001957; GO:0004197; GO:0005615; GO:0005737; GO:0005764; GO:0006508; GO:0008234; GO:0030574; GO:0043394; GO:0045453; GO:0051603; GO:1903146; GO:1903955 0 0 0 PF08246;PF00112; O70277 CHOYP_BRAFLDRAFT_92727.3.17 m.23915 sp TRIM3_RAT 25.316 158 105 5 5 156 593 743 1.54E-07 53.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P10076 CHOYP_LOC100013817.1.1 m.34914 sp ZFP26_MOUSE 26.003 673 383 17 416 1057 243 831 1.54E-57 218 ZFP26_MOUSE reviewed Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) 861 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; P11137 CHOYP_UAFA.1.8 m.5742 sp MTAP2_HUMAN 53.077 130 48 3 1653 1774 1649 1773 1.54E-27 126 MTAP2_HUMAN reviewed Microtubule-associated protein 2 (MAP-2) MAP2 Homo sapiens (Human) 1827 central nervous system neuron development [GO:0021954]; dendrite morphogenesis [GO:0048813]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175] GO:0000226; GO:0001578; GO:0002162; GO:0005198; GO:0005730; GO:0005737; GO:0005874; GO:0005875; GO:0008017; GO:0021954; GO:0031175; GO:0043005; GO:0048813 0 0 0 PF08377;PF00418; P17538 CHOYP_LOC100867874.1.1 m.10813 sp CTRB1_HUMAN 36.885 244 141 4 214 457 33 263 1.54E-49 172 CTRB1_HUMAN reviewed Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C] CTRB1 CTRB Homo sapiens (Human) 263 cobalamin metabolic process [GO:0009235]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617] GO:0004252; GO:0005576; GO:0005615; GO:0007586; GO:0008236; GO:0009235; GO:0022617 0 0 cd00190; PF00089; P21328 CHOYP_LOC100561123.3.28 m.1527 sp RTJK_DROME 27.002 437 282 11 1 423 438 851 1.54E-40 162 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P24928 CHOYP_DMOJ_GI24566.1.1 m.39747 sp RPB1_HUMAN 52.459 61 28 1 113 173 1876 1935 1.54E-07 58.5 RPB1_HUMAN reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) POLR2A POLR2 Homo sapiens (Human) 1970 "7-methylguanosine mRNA capping [GO:0006370]; DNA-templated transcription, termination [GO:0006353]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; gene silencing by RNA [GO:0031047]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of RNA splicing [GO:0033120]; positive regulation of viral transcription [GO:0050434]; regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; somatic stem cell population maintenance [GO:0035019]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000398; GO:0003677; GO:0003899; GO:0003968; GO:0005634; GO:0005654; GO:0005665; GO:0006283; GO:0006353; GO:0006355; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0008543; GO:0010467; GO:0031047; GO:0031625; GO:0033120; GO:0035019; GO:0042795; GO:0044822; GO:0046872; GO:0050434 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; P28648 CHOYP_AAEL_AAEL014311.2.2 m.56253 sp CD63_RAT 28.177 181 113 6 82 259 58 224 1.54E-12 68.9 CD63_RAT reviewed CD63 antigen (Mast cell antigen AD1) (CD antigen CD63) Cd63 Rattus norvegicus (Rat) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigment granule maturation [GO:0048757]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endocytosis [GO:0045807]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005737; GO:0005764; GO:0005765; GO:0005886; GO:0005887; GO:0007160; GO:0007166; GO:0010633; GO:0012505; GO:0015031; GO:0016021; GO:0016477; GO:0030658; GO:0030855; GO:0031226; GO:0031902; GO:0032403; GO:0035646; GO:0042470; GO:0043234; GO:0045785; GO:0045807; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2001046 0 0 0 PF00335; P50133 CHOYP_LOC100690874.1.2 m.62879 sp PTH1R_PIG 41.689 379 198 7 65 425 101 474 1.54E-88 286 PTH1R_PIG reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Sus scrofa (Pig) 585 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular calcium ion homeostasis [GO:0006874]; chondrocyte differentiation [GO:0002062]; negative regulation of cell proliferation [GO:0008285]; osteoblast development [GO:0002076]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cell proliferation [GO:0008284] GO:0002062; GO:0002076; GO:0004991; GO:0005622; GO:0005887; GO:0006874; GO:0007166; GO:0007188; GO:0007189; GO:0007200; GO:0008284; GO:0008285; GO:0017046; GO:0030282; GO:0043621; GO:0045453; GO:0048469; GO:0070062 0 0 0 PF00002;PF02793; P55040 CHOYP_AGAP_AGAP007681.1.1 m.36727 sp GEM_HUMAN 34.818 247 138 8 124 352 55 296 1.54E-27 112 GEM_HUMAN reviewed GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) GEM KIR Homo sapiens (Human) 296 cell surface receptor signaling pathway [GO:0007166]; chromosome organization [GO:0051276]; immune response [GO:0006955]; metaphase plate congression [GO:0051310]; mitotic nuclear division [GO:0007067]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264] GO:0000287; GO:0003924; GO:0005525; GO:0005634; GO:0006955; GO:0007067; GO:0007165; GO:0007166; GO:0007264; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686 0 0 0 PF00071; P59222 CHOYP_BRAFLDRAFT_224574.14.18 m.50503 sp SREC2_MOUSE 38.418 177 100 7 189 365 228 395 1.54E-22 105 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P61354 CHOYP_TRAF7.1.1 m.18345 sp RL27_RAT 81.25 80 15 0 1 80 57 136 1.54E-42 140 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; P62484 CHOYP_ABI2.1.2 m.50130 sp ABI2_MOUSE 66.667 78 21 1 48 125 370 442 1.54E-28 110 ABI2_MOUSE reviewed Abl interactor 2 (Abelson interactor 2) (Abi-2) Abi2 Mus musculus (Mouse) 446 actin polymerization or depolymerization [GO:0008154]; camera-type eye development [GO:0043010]; cell migration [GO:0016477]; dendrite development [GO:0016358]; learning or memory [GO:0007611]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; Rac protein signal transduction [GO:0016601] GO:0005829; GO:0005856; GO:0005913; GO:0007611; GO:0008154; GO:0016358; GO:0016477; GO:0016601; GO:0017124; GO:0018108; GO:0030027; GO:0030175; GO:0030425; GO:0031209; GO:0031625; GO:0032403; GO:0043010; GO:0070064; GO:2000601 0 0 0 PF07815;PF14604; P70684 CHOYP_LOC591898.2.2 m.29158 sp PGDH_CAVPO 40.664 241 137 2 18 252 5 245 1.54E-59 192 PGDH_CAVPO reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) 265 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; P86856 CHOYP_MANL.1.9 m.7979 sp MANL_MYTCA 33.422 374 141 10 56 388 2 308 1.54E-52 181 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q05927 CHOYP_TRIADDRAFT_57018.1.2 m.10706 sp 5NTD_BOVIN 43.894 565 299 11 14 566 15 573 1.54E-160 473 5NTD_BOVIN reviewed 5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73) NT5E NT5 NTE Bos taurus (Bovine) 574 nucleotide catabolic process [GO:0009166] GO:0000166; GO:0005886; GO:0008253; GO:0009166; GO:0031225; GO:0046872 0 0 0 PF02872;PF00149; Q08BL7 CHOYP_LOC101170508.1.1 m.15524 sp GLCTK_DANRE 48.045 179 93 0 63 241 9 187 1.54E-52 181 GLCTK_DANRE reviewed Glycerate kinase (EC 2.7.1.31) glyctk zgc:153346 Danio rerio (Zebrafish) (Brachydanio rerio) 502 protein phosphorylation [GO:0006468] GO:0005524; GO:0005737; GO:0006468; GO:0008887 0 0 0 PF13660;PF05161; Q0VGK4 CHOYP_LOC101174208.1.1 m.65951 sp GDPD1_RAT 52.862 297 137 1 1 297 17 310 1.54E-108 320 GDPD1_RAT reviewed Glycerophosphodiester phosphodiesterase domain-containing protein 1 (EC 3.1.-.-) Gdpd1 Rattus norvegicus (Rat) 314 lipid metabolic process [GO:0006629] GO:0006629; GO:0008889; GO:0016021; GO:0046872 0 0 0 PF03009; Q15573 CHOYP_LOC100889406.1.1 m.12582 sp TAF1A_HUMAN 29.646 226 146 5 7 224 165 385 1.54E-19 91.3 TAF1A_HUMAN reviewed TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A) TAF1A Homo sapiens (Human) 450 "positive regulation of gene expression, epigenetic [GO:0045815]; regulation of transcription, DNA-templated [GO:0006355]; termination of RNA polymerase I transcription [GO:0006363]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription from RNA polymerase II promoter [GO:0006366]; transcription from RNA polymerase I promoter [GO:0006360]; transcription initiation from RNA polymerase I promoter [GO:0006361]" GO:0000120; GO:0003677; GO:0005634; GO:0005654; GO:0006355; GO:0006360; GO:0006361; GO:0006362; GO:0006363; GO:0006366; GO:0015630; GO:0043231; GO:0045815 0 0 0 0 Q20591 CHOYP_LOC753676.1.1 m.61274 sp VA0E_CAEEL 46.914 81 39 1 30 110 5 81 1.54E-20 81.6 VA0E_CAEEL reviewed V-type proton ATPase subunit e (V-ATPase subunit e) (Vacuolar proton pump subunit e) vha-17 F49C12.13 Caenorhabditis elegans 86 ATP hydrolysis coupled proton transport [GO:0015991]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic body morphogenesis [GO:0010172]; regulation of syncytium formation by plasma membrane fusion [GO:0060142] GO:0009792; GO:0010172; GO:0015991; GO:0016021; GO:0016324; GO:0033179; GO:0033181; GO:0043296; GO:0046961; GO:0060142 0 0 0 PF05493; Q29052 CHOYP_LOC100692402.1.2 m.2331 sp ITIH1_PIG 40 135 77 1 1 131 317 451 1.54E-26 106 ITIH1_PIG reviewed Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) ITIH1 Sus scrofa (Pig) 902 hyaluronan metabolic process [GO:0030212] GO:0004867; GO:0005576; GO:0030212 0 0 0 PF06668;PF08487;PF00092; Q2PC93 CHOYP_LOC100210677.4.8 m.27617 sp SSPO_CHICK 28.54 1815 927 78 183 1727 2581 4295 1.54E-104 379 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q4R739 CHOYP_BRAFLDRAFT_98740.6.7 m.59350 sp ANR53_MACFA 36.047 86 50 1 179 259 130 215 1.54E-06 55.1 ANR53_MACFA reviewed Ankyrin repeat domain-containing protein 53 ANKRD53 QtsA-16406 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 496 cell division [GO:0051301]; mitotic metaphase plate congression [GO:0007080]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236] GO:0000922; GO:0005737; GO:0005819; GO:0007080; GO:0031116; GO:0051301; GO:0060236; GO:1902412 0 0 0 PF12796; Q54KA7 CHOYP_AFUA_1G01020.25.50 m.32996 sp SECG_DICDI 35.075 268 156 5 10 275 276 527 1.54E-34 135 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q54SV3 CHOYP_LOC577905.2.2 m.15926 sp ALN1_DICDI 50.847 177 87 0 2 178 275 451 1.54E-64 213 ALN1_DICDI reviewed Probable allantoinase 1 (EC 3.5.2.5) allB1 DDB_G0282199 Dictyostelium discoideum (Slime mold) 649 allantoin catabolic process [GO:0000256]; purine nucleobase metabolic process [GO:0006144] GO:0000256; GO:0004038; GO:0006144; GO:0008270; GO:0016888; GO:0050897 PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. 0 0 PF01979;PF09349; Q5JR59 CHOYP_LOC763960.1.2 m.17062 sp MTUS2_HUMAN 29.781 366 232 6 1283 1638 995 1345 1.54E-36 155 MTUS2_HUMAN reviewed Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) MTUS2 CAZIP KIAA0774 TIP150 Homo sapiens (Human) 1369 0 GO:0005634; GO:0005737; GO:0005874; GO:0008017; GO:0042803 0 0 0 0 Q5MNV8 CHOYP_FBXO47.1.1 m.46116 sp FBX47_HUMAN 35.045 448 270 10 18 454 15 452 1.54E-86 275 FBX47_HUMAN reviewed F-box only protein 47 FBXO47 Homo sapiens (Human) 452 0 0 0 0 0 PF00646; Q5QJC2 CHOYP_DCR1C.1.1 m.35498 sp DCR1C_CHICK 40.102 394 212 8 1 382 1 382 1.54E-79 273 DCR1C_CHICK reviewed Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (SNM1 homolog C) (chSNM1C) (SNM1-like protein) DCLRE1C SNM1C Gallus gallus (Chicken) 714 adaptive immune response [GO:0002250]; DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; protection from non-homologous end joining at telomere [GO:0031848] GO:0000784; GO:0002250; GO:0003684; GO:0004519; GO:0006303; GO:0006310; GO:0031848; GO:0035312; GO:0036297; GO:0070419 0 0 0 PF07522;PF12706; Q5ZIQ3 CHOYP_BRAFLDRAFT_127356.2.2 m.12425 sp HNRPK_CHICK 56.621 219 90 3 15 233 18 231 1.54E-72 236 HNRPK_CHICK reviewed Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK RCJMB04_24e23 Gallus gallus (Chicken) 427 "mRNA processing [GO:0006397]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005654; GO:0005681; GO:0005737; GO:0006351; GO:0006357; GO:0006397; GO:0008380 0 0 0 PF00013;PF08067; Q66KB0 CHOYP_UBE2Z.1.1 m.61760 sp UBE2Z_XENTR 72.581 248 68 0 50 297 40 287 1.54E-138 398 UBE2Z_XENTR reviewed Ubiquitin-conjugating enzyme E2 Z (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Z) (Ubiquitin carrier protein Z) (Ubiquitin-protein ligase Z) ube2z Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 313 apoptotic process [GO:0006915] GO:0005524; GO:0005634; GO:0005737; GO:0006915; GO:0031625; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q6AYN9 CHOYP_BRAFLDRAFT_132233.1.4 m.13687 sp CC181_RAT 26.316 380 220 12 251 584 143 508 1.54E-18 92.4 CC181_RAT reviewed Coiled-coil domain-containing protein 181 Ccdc181 Rattus norvegicus (Rat) 509 0 GO:0005654 0 0 0 0 Q6DFF6 CHOYP_LOC100367192.1.2 m.52294 sp KLH20_XENLA 38.215 594 344 9 21 599 1 586 1.54E-126 389 KLH20_XENLA reviewed Kelch-like protein 20 klhl20 Xenopus laevis (African clawed frog) 604 Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005802; GO:0005829; GO:0006895; GO:0015031; GO:0016567; GO:0016605; GO:0019964; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6PBY1 CHOYP_RS3A.6.15 m.19121 sp RS3A_DANRE 84.375 64 10 0 104 167 1 64 1.54E-26 104 RS3A_DANRE reviewed 40S ribosomal protein S3a rps3a Danio rerio (Zebrafish) (Brachydanio rerio) 267 chordate embryonic development [GO:0043009]; translation [GO:0006412] GO:0003735; GO:0005829; GO:0006412; GO:0022627; GO:0043009 0 0 0 PF01015; Q6PDL0 CHOYP_DC1L1.1.1 m.22572 sp DC1L2_MOUSE 54.902 153 63 4 2 151 302 451 1.54E-40 147 DC1L2_MOUSE reviewed "Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic)" Dync1li2 Dncli2 Dnclic2 Mus musculus (Mouse) 492 centrosome localization [GO:0051642]; microtubule-based movement [GO:0007018]; microtubule cytoskeleton organization [GO:0000226]; transport [GO:0006810] GO:0000226; GO:0003777; GO:0005524; GO:0005737; GO:0005813; GO:0005868; GO:0005874; GO:0006810; GO:0007018; GO:0016020; GO:0051642 0 0 0 PF05783; Q6PFY8 CHOYP_LOC100373444.12.79 m.13482 sp TRI45_MOUSE 23.827 277 188 9 4 263 127 397 1.54E-08 60.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PID6 CHOYP_LOC100889497.1.1 m.18636 sp TTC33_HUMAN 40.449 267 137 4 1 258 1 254 1.54E-58 191 TTC33_HUMAN reviewed Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor) TTC33 Homo sapiens (Human) 262 0 0 0 0 0 0 Q6YHK3 CHOYP_TRIADDRAFT_55768.1.2 m.4474 sp CD109_HUMAN 34.821 224 134 5 19 233 28 248 1.54E-35 137 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q7K237 CHOYP_AGAP_AGAP009979.1.1 m.12551 sp C1GLT_DROME 54.094 342 140 3 3 340 18 346 1.54E-129 382 C1GLT_DROME reviewed "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GalTA CG9520 Drosophila melanogaster (Fruit fly) 388 "central nervous system morphogenesis [GO:0021551]; glycolipid biosynthetic process [GO:0009247]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; O-glycan processing, core 1 [GO:0016267]; protein glycosylation [GO:0006486]; regulation of filopodium assembly [GO:0051489]" GO:0006486; GO:0009247; GO:0016021; GO:0016263; GO:0016267; GO:0021551; GO:0046872; GO:0048531; GO:0051489; GO:1902037 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02434; Q7KRY7 CHOYP_LOC100866332.1.1 m.372 sp LAP4_DROME 58.859 491 189 5 1 488 1 481 1.54E-178 587 LAP4_DROME reviewed Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) 1851 "anterior/posterior axis specification, follicular epithelium [GO:0030714]; asymmetric protein localization [GO:0008105]; cell fate commitment involved in pattern specification [GO:0060581]; cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; compound eye development [GO:0048749]; dorsal closure [GO:0007391]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; Malpighian tubule development [GO:0072002]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; morphogenesis of follicular epithelium [GO:0016333]; morphogenesis of larval imaginal disc epithelium [GO:0016335]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; olfactory behavior [GO:0042048]; ovarian follicle cell development [GO:0030707]; pole plasm protein localization [GO:0007318]; positive regulation of heart contraction [GO:0045823]; R3/R4 cell fate commitment [GO:0007464]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of JAK-STAT cascade [GO:0046425]; regulation of Notch signaling pathway [GO:0008593]; regulation of synapse structure or activity [GO:0050803]; sensory perception of smell [GO:0007608]; septate junction assembly [GO:0019991]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; wing disc morphogenesis [GO:0007472]; zonula adherens assembly [GO:0045186]" GO:0000122; GO:0000902; GO:0001708; GO:0001737; GO:0001738; GO:0005179; GO:0005576; GO:0005918; GO:0005923; GO:0007318; GO:0007391; GO:0007464; GO:0007472; GO:0007608; GO:0008105; GO:0008283; GO:0008285; GO:0008593; GO:0016323; GO:0016327; GO:0016328; GO:0016331; GO:0016332; GO:0016333; GO:0016334; GO:0016335; GO:0016336; GO:0019991; GO:0030100; GO:0030707; GO:0030714; GO:0031594; GO:0035088; GO:0042048; GO:0042058; GO:0042067; GO:0045169; GO:0045186; GO:0045197; GO:0045198; GO:0045571; GO:0045823; GO:0046425; GO:0048749; GO:0048863; GO:0050680; GO:0050803; GO:0051726; GO:0060581; GO:0072002; GO:0072089 0 0 0 PF13855;PF00595; Q7T0M6 CHOYP_ISCW_ISCW013556.1.1 m.26406 sp AS1AB_XENLA 65.049 206 62 2 1 203 1 199 1.54E-91 269 AS1AB_XENLA reviewed Histone chaperone asf1a-B (Anti-silencing function protein 1 homolog A-B) asf1ab asf1a Xenopus laevis (African clawed frog) 200 "chromatin assembly or disassembly [GO:0006333]; covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006333; GO:0006351; GO:0006355; GO:0016569 0 0 0 PF04729; Q7T3N8 CHOYP_RL15.3.3 m.65916 sp RL15_CTEID 80 115 23 0 1 115 1 115 1.54E-62 192 RL15_CTEID reviewed 60S ribosomal protein L15 rpl15 Ctenopharyngodon idella (Grass carp) (Leuciscus idella) 204 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00827; Q8CEE6 CHOYP_LOC100375061.1.1 m.19347 sp PASK_MOUSE 51.151 391 171 4 944 1331 952 1325 1.54E-116 401 PASK_MOUSE reviewed PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (EC 2.7.11.1) Pask Kiaa0135 Mus musculus (Mouse) 1383 negative regulation of glycogen biosynthetic process [GO:0045719]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of energy homeostasis [GO:2000505]; regulation of glucagon secretion [GO:0070092]; regulation of respiratory gaseous exchange [GO:0043576] GO:0004674; GO:0005524; GO:0005622; GO:0005634; GO:0005737; GO:0005794; GO:0006468; GO:0035091; GO:0043576; GO:0045719; GO:0046777; GO:0070092; GO:2000505 0 0 0 PF13426;PF00069; Q8CHB8 CHOYP_LOC100177360.1.1 m.12338 sp TTLL5_MOUSE 53.333 60 28 0 1 60 458 517 1.54E-16 82 TTLL5_MOUSE reviewed Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 5) Ttll5 Kiaa0998 Mus musculus (Mouse) 1328 "fertilization [GO:0009566]; protein polyglutamylation [GO:0018095]; retina development in camera-type eye [GO:0060041]; spermatogenesis [GO:0007283]; sperm axoneme assembly [GO:0007288]; sperm motility [GO:0030317]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0005929; GO:0006351; GO:0007283; GO:0007288; GO:0009566; GO:0016874; GO:0018095; GO:0030317; GO:0060041 0 0 0 PF03133; Q92805 CHOYP_LOC100888300.1.2 m.10203 sp GOGA1_HUMAN 33.017 421 224 7 1 407 1 377 1.54E-41 167 GOGA1_HUMAN reviewed Golgin subfamily A member 1 (Golgin-97) GOLGA1 Homo sapiens (Human) 767 protein targeting to Golgi [GO:0000042] GO:0000042; GO:0005794; GO:0005802; GO:0005829; GO:0032580; GO:0043231; GO:0048471 0 0 0 PF01465; Q95SX7 CHOYP_LOC100889728.1.1 m.34932 sp RTBS_DROME 20.221 272 199 3 1 262 613 876 1.54E-06 53.9 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q96XY5 CHOYP_LOC100368311.2.2 m.50641 sp Y2383_SULTO 44.604 139 72 1 404 542 1 134 1.54E-31 123 Y2383_SULTO reviewed Uncharacterized protein STK_23830 STK_23830 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 182 0 0 0 0 0 PF01661; Q99572 CHOYP_LOC100376482.3.7 m.10317 sp P2RX7_HUMAN 26.061 165 103 5 41 204 446 592 1.54E-07 54.3 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; Q99L13 CHOYP_BRAFLDRAFT_270300.1.1 m.59680 sp 3HIDH_MOUSE 61.039 308 113 1 41 348 31 331 1.54E-133 387 3HIDH_MOUSE reviewed "3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)" Hibadh Mus musculus (Mouse) 335 branched-chain amino acid catabolic process [GO:0009083]; valine catabolic process [GO:0006574] GO:0004616; GO:0005739; GO:0006574; GO:0008442; GO:0009083; GO:0051287 PATHWAY: Amino-acid degradation; L-valine degradation. 0 0 PF14833;PF03446; Q9CXK9 CHOYP_LOC100879804.1.1 m.59833 sp RBM33_MOUSE 36.275 102 54 3 941 1031 1128 1229 1.54E-08 62.8 RBM33_MOUSE reviewed RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33) Rbm33 Prr8 Mus musculus (Mouse) 1231 0 GO:0000166; GO:0044822 0 0 0 0 Q9CZJ2 CHOYP_BRAFLDRAFT_208197.3.21 m.18641 sp HS12B_MOUSE 37.105 380 178 9 12 343 61 427 1.54E-71 239 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D994 CHOYP_LOC100892811.2.2 m.29997 sp WDR38_MOUSE 44.71 293 160 2 2 293 8 299 1.54E-80 249 WDR38_MOUSE reviewed WD repeat-containing protein 38 Wdr38 Mus musculus (Mouse) 303 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244 0 0 0 PF00400; Q9EPH8 CHOYP_PABPA.1.1 m.48963 sp PABP1_RAT 82.955 88 15 0 19 106 536 623 1.54E-39 142 PABP1_RAT reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Rattus norvegicus (Rat) 636 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0003729; GO:0005681; GO:0006397; GO:0008143; GO:0008380; GO:0010494; GO:0030425; GO:0030529; GO:0031047; GO:0060213; GO:1900153; GO:1990124; GO:2000623 0 0 0 PF00658;PF00076; Q9ESN6 CHOYP_BRAFLDRAFT_67284.1.2 m.39915 sp TRIM2_MOUSE 22.46 187 137 6 320 500 547 731 1.54E-06 54.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H0J9 CHOYP_LOC100496973.4.8 m.55256 sp PAR12_HUMAN 27.7 213 139 6 67 272 13 217 1.54E-15 84.7 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9R0U1 CHOYP_IP6K2.1.2 m.2944 sp IP6K2_RAT 30.769 117 70 2 9 125 11 116 1.54E-12 66.2 IP6K2_RAT reviewed Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (EC 2.7.4.21) (P(i)-uptake stimulator) (PiUS) Ip6k2 Ihpk2 Pius Rattus norvegicus (Rat) 425 negative regulation of cell growth [GO:0030308]; phosphate ion transport [GO:0006817]; phosphatidylinositol phosphorylation [GO:0046854]; positive regulation of apoptotic process [GO:0043065] GO:0000832; GO:0005524; GO:0005634; GO:0006817; GO:0008440; GO:0030308; GO:0043065; GO:0045111; GO:0046854; GO:0052723; GO:0052724 0 0 0 PF03770; Q9R1R2 CHOYP_BRAFLDRAFT_87338.1.7 m.20465 sp TRIM3_MOUSE 28.333 120 81 3 64 179 625 743 1.54E-08 57.4 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UJT1 CHOYP_BRAFLDRAFT_216407.1.1 m.53112 sp TBD_HUMAN 27.056 462 262 15 1 399 1 450 1.54E-42 157 TBD_HUMAN reviewed Tubulin delta chain (Delta-tubulin) TUBD1 TUBD Homo sapiens (Human) 453 cell differentiation [GO:0030154]; microtubule-based process [GO:0007017]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0003924; GO:0005200; GO:0005525; GO:0005654; GO:0005737; GO:0005814; GO:0005874; GO:0007017; GO:0007275; GO:0007283; GO:0030154 0 0 0 PF00091; Q9VCA2 CHOYP_ORCT.6.6 m.56938 sp ORCT_DROME 34.171 597 325 12 1 579 1 547 1.54E-101 321 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9Y233 CHOYP_LOC101162470.1.1 m.49788 sp PDE10_HUMAN 36.933 750 461 6 26 766 7 753 1.54E-177 531 PDE10_HUMAN reviewed "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35)" PDE10A Homo sapiens (Human) 779 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of protein kinase A signaling [GO:0010738]; signal transduction [GO:0007165] GO:0004114; GO:0004115; GO:0004118; GO:0005829; GO:0006198; GO:0007165; GO:0008144; GO:0010738; GO:0016020; GO:0030552; GO:0030553; GO:0043204; GO:0043949; GO:0046069; GO:0046872; GO:0047555 "PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.; PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1." 0 0 PF01590;PF00233; Q9Y2K6 CHOYP_UBP20.1.2 m.2795 sp UBP20_HUMAN 49.434 265 95 4 1 252 39 277 1.54E-82 268 UBP20_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2) USP20 KIAA1003 LSFR3A VDU2 Homo sapiens (Human) 914 endocytosis [GO:0006897]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001664; GO:0004197; GO:0004843; GO:0005813; GO:0006511; GO:0006897; GO:0008270; GO:0008277; GO:0016579; GO:0048471; GO:0070536; GO:0071108 0 0 0 PF06337;PF00443;PF02148; Q9Z255 CHOYP_UBE2A.1.1 m.48761 sp UBE2A_MOUSE 84.615 156 19 1 1 156 1 151 1.54E-97 281 UBE2A_MOUSE reviewed Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (mHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) Ube2a Rad6a Mus musculus (Mouse) 152 DNA repair [GO:0006281]; histone H2A ubiquitination [GO:0033522]; histone ubiquitination [GO:0016574]; in utero embryonic development [GO:0001701]; maternal process involved in female pregnancy [GO:0060135]; positive regulation of cell proliferation [GO:0008284]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to UV [GO:0009411] GO:0000209; GO:0000785; GO:0000790; GO:0001701; GO:0001741; GO:0004842; GO:0005524; GO:0005737; GO:0006281; GO:0008284; GO:0009411; GO:0016567; GO:0016574; GO:0031625; GO:0033503; GO:0033522; GO:0043161; GO:0051865; GO:0060135; GO:0061630; GO:0061631; GO:0070936; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; A0A0R4IBK5 CHOYP_LOC100377154.3.4 m.52896 sp R213A_DANRE 30 710 450 17 1290 1971 1028 1718 1.55E-80 301 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A0MSJ1 CHOYP_CAS4.1.1 m.58199 sp CRA1B_DANRE 48 175 85 1 88 256 746 920 1.55E-23 105 CRA1B_DANRE reviewed Collagen alpha-1(XXVII) chain B col27a1b col27a1 Danio rerio (Zebrafish) (Brachydanio rerio) 1658 bone mineralization [GO:0030282]; notochord morphogenesis [GO:0048570]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005578; GO:0005581; GO:0030282; GO:0046872; GO:0048570 0 0 0 PF01410;PF01391; A2ASS6 CHOYP_LOC100566306.1.1 m.39504 sp TITIN_MOUSE 25.587 426 214 18 28 432 3007 3350 1.55E-12 74.3 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A4IF63 CHOYP_BRAFLDRAFT_88223.16.22 m.53861 sp TRIM2_BOVIN 23.256 215 141 7 17 219 492 694 1.55E-09 60.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NF83 CHOYP_ISCW_ISCW005287.6.6 m.50370 sp NUPR2_HUMAN 37.5 72 44 1 29 100 15 85 1.55E-07 48.5 NUPR2_HUMAN reviewed Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2) NUPR2 NUPR1L Homo sapiens (Human) 97 "cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to starvation [GO:0009267]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003682; GO:0005634; GO:0006351; GO:0006974; GO:0007050; GO:0008285; GO:0009267; GO:0071157 0 0 0 PF10195; B2RX88 CHOYP_CSPP1.1.14 m.9773 sp CSPP1_MOUSE 34.589 717 363 24 726 1381 498 1169 1.55E-56 219 CSPP1_MOUSE reviewed Centrosome and spindle pole associated protein 1 Cspp1 Cspp Mus musculus (Mouse) 1205 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 B2RXR6 CHOYP_LOC587475.2.3 m.34887 sp ANR44_MOUSE 28.663 778 436 18 579 1298 75 791 1.55E-69 258 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; D3YXG0 CHOYP_LOC100370299.2.2 m.65413 sp HMCN1_MOUSE 25.551 227 135 9 10 216 1411 1623 1.55E-11 66.6 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; G4V4G1 CHOYP_LOC100551326.1.1 m.1869 sp IGFBP_CUPSA 38.125 160 99 0 8 167 96 255 1.55E-36 130 IGFBP_CUPSA reviewed Insulin-like growth factor-binding protein-related protein 1 (IGFBP-rP1) 0 Cupiennius salei (American wandering spider) 261 regulation of cell growth [GO:0001558] GO:0001558; GO:0004867; GO:0005576 0 0 0 PF00219;PF00050; O07552 CHOYP_SMP_076400.2.2 m.49169 sp NHAX_BACSU 32.911 79 53 0 119 197 86 164 1.55E-09 58.2 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O14867 CHOYP_LOC100575377.1.10 m.10592 sp BACH1_HUMAN 28.205 117 84 0 7 123 11 127 1.55E-09 64.7 BACH1_HUMAN reviewed Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) 736 "DNA repair [GO:0006281]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]" GO:0000083; GO:0000117; GO:0000122; GO:0000980; GO:0001078; GO:0001205; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006281; GO:0006355; GO:0016567; GO:0020037; GO:0031463; GO:0061418 0 0 0 PF00651;PF03131; O15297 CHOYP_LOC100644827.1.1 m.10029 sp PPM1D_HUMAN 47.603 292 140 3 72 363 99 377 1.55E-85 285 PPM1D_HUMAN reviewed Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) PPM1D WIP1 Homo sapiens (Human) 605 cellular response to starvation [GO:0009267]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of cell proliferation [GO:0008285]; peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470]; response to bacterium [GO:0009617]; response to radiation [GO:0009314] GO:0000086; GO:0004722; GO:0005634; GO:0006470; GO:0008285; GO:0009267; GO:0009314; GO:0009617; GO:0035970; GO:0046872; GO:0051019 0 0 0 PF00481; O16277 CHOYP_LOC100635715.7.9 m.49771 sp H16_CAEEL 53.425 73 33 1 30 101 53 125 1.55E-13 68.2 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O35790 CHOYP_AAEL_AAEL004143.1.1 m.14387 sp PIGL_RAT 39.2 250 146 2 25 268 1 250 1.55E-54 181 PIGL_RAT reviewed N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L) Pigl Rattus norvegicus (Rat) 252 GPI anchor biosynthetic process [GO:0006506] GO:0000225; GO:0005783; GO:0005789; GO:0006506; GO:0016021 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF02585; O70277 CHOYP_BRAFLDRAFT_87307.4.5 m.60183 sp TRIM3_RAT 24.521 261 177 8 225 472 489 742 1.55E-10 67 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O73853 CHOYP_TBA.2.6 m.22412 sp CP17A_ICTPU 34.31 478 298 8 31 499 31 501 1.55E-88 285 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; O76190 CHOYP_LOC100186763.2.2 m.27544 sp RL5_BOMMO 65.672 134 45 1 13 145 148 281 1.55E-55 185 RL5_BOMMO reviewed 60S ribosomal protein L5 RpL5 Bombyx mori (Silk moth) 299 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; P04323 CHOYP_LOC100695950.4.6 m.17934 sp POL3_DROME 31.098 865 526 29 146 981 148 971 1.55E-105 362 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P06144 CHOYP_ALS2.2.3 m.37861 sp H1_LYTPI 65.753 73 25 0 61 133 18 90 1.55E-21 91.7 H1_LYTPI reviewed Late histone H1 0 Lytechinus pictus (Painted sea urchin) 210 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; P16157 CHOYP_AFUA_1G01020.27.50 m.33130 sp ANK1_HUMAN 36.585 451 285 1 17 467 208 657 1.55E-71 249 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P21613 CHOYP_KINH.8.9 m.44889 sp KINH_DORPE 75.369 203 48 2 254 456 725 925 1.55E-87 290 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P22334 CHOYP_ILP.1.1 m.29063 sp ILP_BRACL 32.632 95 62 1 24 116 7 101 1.55E-07 53.9 ILP_BRACL reviewed Insulin-like peptide [Cleaved into: Insulin-like peptide B chain; Insulin-like peptide A chain] ILP Branchiostoma californiense (California lancelet) (Amphioxus) 305 glucose metabolic process [GO:0006006] GO:0005576; GO:0006006 0 0 0 PF00049; P24456 CHOYP_CP2DR.1.1 m.26017 sp CP2DA_MOUSE 25 260 185 4 1 256 4 257 1.55E-21 97.4 CP2DA_MOUSE reviewed Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (Cytochrome P450-16-alpha) (Cytochrome P450CB) (Testosterone 16-alpha hydroxylase) Cyp2d10 Cyp2d-10 Mus musculus (Mouse) 504 arachidonic acid metabolic process [GO:0019369] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019369; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P39872 CHOYP_RL3.1.7 m.17999 sp RL3_BOVIN 76.692 133 31 0 1 133 1 133 1.55E-69 218 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; P55201 CHOYP_BRPF1.1.1 m.50265 sp BRPF1_HUMAN 51.955 179 81 2 230 404 1037 1214 1.55E-49 183 BRPF1_HUMAN reviewed Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) BRPF1 BR140 Homo sapiens (Human) 1214 "histone H3 acetylation [GO:0043966]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0008270; GO:0043966; GO:0045893; GO:0070776; GO:1901796 0 0 0 PF00439;PF10513;PF00855; P90689 CHOYP_ACT.2.27 m.1778 sp ACT_BRUMA 45.238 252 98 1 2 213 86 337 1.55E-71 224 ACT_BRUMA reviewed Actin 0 Brugia malayi (Filarial nematode worm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q00546 CHOYP_LOC100635750.1.1 m.62847 sp TENR_CHICK 50.299 167 75 3 1 163 1165 1327 1.55E-53 192 TENR_CHICK reviewed Tenascin-R (TN-R) (Restrictin) TNR Gallus gallus (Chicken) 1353 cell adhesion [GO:0007155]; regulation of neurogenesis [GO:0050767] GO:0005578; GO:0007155; GO:0050767 0 0 0 PF00147;PF00041; Q02079 CHOYP_LOC100206475.1.16 m.4004 sp LAC3_THACU 37.5 296 153 9 95 383 33 303 1.55E-43 169 LAC3_THACU reviewed Laccase-3 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 3) (Diphenol oxidase 3) (Urishiol oxidase 3) LCC3 Thanatephorus cucumeris (Black scurf of potato) (Rhizoctonia solani) 572 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q03145 CHOYP_LOC100745315.1.1 m.67050 sp EPHA2_MOUSE 37.931 261 143 7 165 417 616 865 1.55E-49 191 EPHA2_MOUSE reviewed Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2) Epha2 Eck Myk2 Sek2 Mus musculus (Mouse) 977 activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel morphogenesis [GO:0048514]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production [GO:0001818]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of protein kinase B signaling [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; post-anal tail morphogenesis [GO:0036342]; protein kinase B signaling [GO:0043491]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570] GO:0001501; GO:0001568; GO:0001570; GO:0001649; GO:0001818; GO:0002043; GO:0004714; GO:0005003; GO:0005524; GO:0005622; GO:0005886; GO:0005887; GO:0005925; GO:0006954; GO:0007155; GO:0008630; GO:0009986; GO:0010591; GO:0014028; GO:0016477; GO:0016525; GO:0021915; GO:0030182; GO:0030216; GO:0030316; GO:0031256; GO:0031258; GO:0032587; GO:0032682; GO:0033598; GO:0033628; GO:0036342; GO:0043491; GO:0043535; GO:0045765; GO:0046849; GO:0048013; GO:0048320; GO:0048514; GO:0048570; GO:0050830; GO:0051898; GO:0060035; GO:0060326; GO:0060444; GO:0070309; GO:0070372; GO:0070848; GO:0090004; GO:0090630; GO:1901491; GO:1904238 0 0 0 PF14575;PF01404;PF00041;PF07714;PF00536; Q17QJ5 CHOYP_LOC100374248.5.5 m.66668 sp TSN5_BOVIN 27.329 161 108 3 97 257 14 165 1.55E-14 75.5 TSN5_BOVIN reviewed Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) 268 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007166; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q20191 CHOYP_LOC581452.2.4 m.25348 sp NAS13_CAEEL 32.873 362 192 14 81 410 108 450 1.55E-45 171 NAS13_CAEEL reviewed Zinc metalloproteinase nas-13 (EC 3.4.24.21) (Nematode astacin 13) nas-13 F39D8.4 Caenorhabditis elegans 450 0 GO:0004222; GO:0005576; GO:0008270 0 0 0 PF01400;PF01549; Q4V9P0 CHOYP_BRAFLDRAFT_72535.1.1 m.7201 sp SAMC_DANRE 55.639 266 117 1 1 265 1 266 1.55E-104 307 SAMC_DANRE reviewed S-adenosylmethionine mitochondrial carrier protein (Mitochondrial S-adenosylmethionine transporter) (Solute carrier family 25 member 26) slc25a26 samc zgc:110080 Danio rerio (Zebrafish) (Brachydanio rerio) 267 S-adenosyl-L-methionine transport [GO:0015805]; translation [GO:0006412] GO:0000095; GO:0003735; GO:0005743; GO:0006412; GO:0015805; GO:0016021 0 0 0 PF00153; Q5AF03 CHOYP_LOC100199980.2.2 m.62746 sp HSP31_CANAL 32.743 226 126 7 3 210 2 219 1.55E-26 104 HSP31_CANAL reviewed Glyoxalase 3 (EC 4.2.1.130) (Glutathione-independent glyoxalase) GLX3 CaO19.251 CaO19.7882 orf19.251 orf19.7882 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 236 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] GO:0019172; GO:0019243 0 0 0 PF01965; Q5R5M0 CHOYP_BRAFLDRAFT_259734.1.1 m.23051 sp MTCH2_PONAB 42.857 273 143 5 17 278 19 289 1.55E-67 215 MTCH2_PONAB reviewed Mitochondrial carrier homolog 2 MTCH2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 303 transport [GO:0006810] GO:0005743; GO:0006810; GO:0016021 0 0 0 PF00153; Q5RDQ8 CHOYP_LOC100374272.6.6 m.62213 sp GRM7_PONAB 26.778 478 300 17 537 982 47 506 1.55E-38 159 GRM7_PONAB reviewed Metabotropic glutamate receptor 7 (mGluR7) GRM7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 922 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [GO:0007196]; sensory perception of smell [GO:0007608] GO:0001642; GO:0005886; GO:0007196; GO:0007608; GO:0008066; GO:0016021 0 0 0 PF00003;PF01094;PF07562; Q6GLJ1 CHOYP_W07A12.4.1.1 m.6829 sp BTBDH_XENLA 23.95 238 158 5 9 240 42 262 1.55E-17 87.8 BTBDH_XENLA reviewed BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) 470 0 GO:0005576 0 0 0 PF07707;PF00651; Q6IZ48 CHOYP_SOX9.1.1 m.46620 sp SOX8_TETNG 46.316 95 49 1 176 270 89 181 1.55E-17 90.9 SOX8_TETNG reviewed Transcription factor Sox-8 sox8 GSTENG00018540001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 462 "transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0005634; GO:0006351 0 0 0 PF00505;PF12444; Q6NT16 CHOYP_C6ORF192.1.1 m.4664 sp S18B1_HUMAN 43.038 316 170 5 61 370 14 325 1.55E-60 205 S18B1_HUMAN reviewed MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) SLC18B1 C6orf192 Homo sapiens (Human) 456 0 GO:0005887; GO:0022857 0 0 cd06174; PF07690; Q6PDJ1 CHOYP_NEMVEDRAFT_V1G238894.11.11 m.64041 sp CAHD1_MOUSE 27.54 1053 674 37 44 1033 59 1085 1.55E-94 332 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6RFZ7 CHOYP_PLEKHG5.3.3 m.55611 sp PKHG5_RAT 36.41 780 371 18 316 1038 7 718 1.55E-137 451 PKHG5_RAT reviewed Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Neuronal RhoA GEF protein) (Transcript highly enriched in cortex and hippocampus) Plekhg5 Tech Rattus norvegicus (Rat) 1039 endothelial cell chemotaxis [GO:0035767]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005737; GO:0005886; GO:0005911; GO:0030027; GO:0030139; GO:0035023; GO:0035767; GO:0048471 0 0 0 PF00621; Q6ZMV9 CHOYP_LOC100372958.1.1 m.9476 sp KIF6_HUMAN 42.678 478 216 6 4 474 6 432 1.55E-103 351 KIF6_HUMAN reviewed Kinesin-like protein KIF6 KIF6 C6orf102 Homo sapiens (Human) 814 microtubule-based movement [GO:0007018] GO:0001673; GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF00225; Q7T3S5 CHOYP_B3GN5.4.4 m.61204 sp B3G5A_DANRE 29.825 285 176 10 79 352 74 345 1.55E-27 114 B3G5A_DANRE reviewed "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A (EC 2.4.1.206) (Lactotriaosylceramide synthase A) (Lc(3)Cer synthase A) (Lc3 synthase A) (UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A) (BGnT-5A) (Beta-1,3-Gn-T5A) (Beta-1,3-N-acetylglucosaminyltransferase 5A) (Beta3Gn-T5A)" b3gnt5a b3gnt5 Danio rerio (Zebrafish) (Brachydanio rerio) 379 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021; GO:0047256 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q80VI1 CHOYP_TRI45.13.23 m.35793 sp TRI56_MOUSE 19.974 771 524 23 46 784 18 727 1.55E-18 94.4 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q86XZ4 CHOYP_LOC590756.2.6 m.28777 sp SPAS2_HUMAN 35.204 392 207 5 7 389 28 381 1.55E-50 187 SPAS2_HUMAN reviewed Spermatogenesis-associated serine-rich protein 2 (Serine-rich spermatocytes and round spermatid 59 kDa protein) (p59scr) SPATS2 SCR59 SPATA10 Nbla00526 Homo sapiens (Human) 545 0 GO:0005737; GO:0044822 0 0 0 PF07139; Q8N2E2 CHOYP_LOC100176485.1.1 m.6691 sp VWDE_HUMAN 41.429 70 41 0 402 471 1390 1459 1.55E-10 67.8 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N884 CHOYP_MB21D1.1.5 m.4236 sp CGAS_HUMAN 27.717 368 224 17 194 536 159 509 1.55E-20 98.6 CGAS_HUMAN reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (h-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 C6orf150 Homo sapiens (Human) 522 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of type I interferon production [GO:0032481] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0032481; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8R344 CHOYP_AAEL_AAEL009922.1.1 m.41820 sp CCD12_MOUSE 55.625 160 60 2 3 151 7 166 1.55E-46 152 CCD12_MOUSE reviewed Coiled-coil domain-containing protein 12 Ccdc12 Mus musculus (Mouse) 166 0 0 0 0 0 PF08315; Q8TCE9 CHOYP_LOC101156514.1.1 m.23656 sp PPL13_HUMAN 33.333 66 41 2 2 66 63 126 1.55E-06 47 PPL13_HUMAN reviewed Placental protein 13-like (Charcot-Leyden crystal protein 2) (CLC2) (Galectin-14) (Gal-14) LGALS14 PPL13 Homo sapiens (Human) 139 apoptotic process [GO:0006915]; positive regulation of T cell apoptotic process [GO:0070234] GO:0005634; GO:0006915; GO:0030246; GO:0070234 0 0 0 PF00337; Q8TDB6 CHOYP_PAR14.9.17 m.38378 sp DTX3L_HUMAN 53.514 185 85 1 1553 1737 556 739 1.55E-54 208 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8VDK3 CHOYP_TAG-97.2.2 m.14472 sp ELF5_MOUSE 31.034 174 102 5 490 655 85 248 1.55E-17 86.7 ELF5_MOUSE reviewed ETS-related transcription factor Elf-5 (E74-like factor 5) Elf5 Mus musculus (Mouse) 253 ectodermal cell fate commitment [GO:0001712]; ectoderm development [GO:0007398]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell differentiation [GO:0045596]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; somatic stem cell population maintenance [GO:0035019] GO:0000977; GO:0001228; GO:0001712; GO:0005634; GO:0005737; GO:0007398; GO:0035019; GO:0045596; GO:0045944; GO:0060644 0 0 0 PF00178;PF02198; Q91VW5 CHOYP_GOLGA4.1.3 m.4761 sp GOGA4_MOUSE 38.621 145 82 2 109 252 116 254 1.55E-21 98.2 GOGA4_MOUSE reviewed Golgin subfamily A member 4 (tGolgin-1) Golga4 Mus musculus (Mouse) 2238 Golgi to plasma membrane protein transport [GO:0043001]; positive regulation of axon extension [GO:0045773]; protein targeting to Golgi [GO:0000042] GO:0000042; GO:0000139; GO:0005654; GO:0005737; GO:0005794; GO:0043001; GO:0043231; GO:0045773; GO:0051020; GO:0070062 0 0 0 PF01465; Q92626 CHOYP_HMCN1.31.44 m.53525 sp PXDN_HUMAN 24.06 399 262 15 192 579 247 615 1.55E-07 60.5 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q95WA0 CHOYP_NEMVEDRAFT_V1G236320.1.1 m.20225 sp RL26_LITLI 71.111 135 36 2 17 148 1 135 1.55E-58 181 RL26_LITLI reviewed 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) 144 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 0 PF00467;PF16906; Q99MS3 CHOYP_MP17L.1.1 m.6785 sp MP17L_MOUSE 34.839 155 93 3 10 162 24 172 1.55E-29 110 MP17L_MOUSE reviewed Mpv17-like protein (M-LP) Mpv17l Mus musculus (Mouse) 194 negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; reactive oxygen species metabolic process [GO:0072593] GO:0005102; GO:0005739; GO:0005777; GO:0005778; GO:0010730; GO:0016021; GO:0043231; GO:0072593; GO:1901029 0 0 0 PF04117; Q9C029 CHOYP_BRAFLDRAFT_82738.1.1 m.51876 sp TRIM7_HUMAN 21.348 178 131 4 84 257 130 302 1.55E-06 54.7 TRIM7_HUMAN reviewed Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90) TRIM7 GNIP RNF90 Homo sapiens (Human) 511 0 GO:0005634; GO:0005737; GO:0008270 0 0 0 PF13765;PF00622;PF00643; Q9D845 CHOYP_LOC100892369.1.1 m.23089 sp TEX9_MOUSE 48.737 396 188 6 292 685 4 386 1.55E-105 329 TEX9_MOUSE reviewed Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1) Tex9 Mus musculus (Mouse) 387 0 0 0 0 0 0 Q9D9N8 CHOYP_NEMVEDRAFT_V1G187084.1.1 m.63082 sp PADC1_MOUSE 41.379 174 102 0 52 225 15 188 1.55E-46 155 PADC1_MOUSE reviewed Protease-associated domain-containing protein 1 (Protease-associated domain-containing protein of 21 kDa) Pradc1 Pap21 Mus musculus (Mouse) 188 0 GO:0005576; GO:0070062 0 0 0 PF02225; Q9JJJ7 CHOYP_LOC577959.1.2 m.13376 sp PORCN_MOUSE 45.833 336 151 7 9 317 126 457 1.55E-88 275 PORCN_MOUSE reviewed Protein-serine O-palmitoleoyltransferase porcupine (mPORC) (EC 2.3.1.-) Porcn Porc Ppn Mus musculus (Mouse) 461 canonical Wnt signaling pathway [GO:0060070]; glycoprotein metabolic process [GO:0009100]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; Wnt signaling pathway [GO:0016055] GO:0005783; GO:0005789; GO:0006497; GO:0008374; GO:0009100; GO:0016055; GO:0017147; GO:0030176; GO:0032281; GO:0045234; GO:0060070; GO:1990698 0 0 0 PF03062; Q9LJN4 CHOYP_LOC100375395.2.2 m.64190 sp BXL5_ARATH 34.232 482 268 11 55 516 11 463 1.55E-72 249 BXL5_ARATH reviewed Probable beta-D-xylosidase 5 (AtBXL5) (EC 3.2.1.-) BXL5 At3g19620 MMB12.15 Arabidopsis thaliana (Mouse-ear cress) 781 carbohydrate metabolic process [GO:0005975] GO:0004553; GO:0005578; GO:0005618; GO:0005975 0 0 0 PF14310;PF00933;PF01915; Q9U1M2 CHOYP_PHUM_PHUM320270.1.1 m.36337 sp TM120_DROME 49.275 345 170 2 11 355 2 341 1.55E-113 338 TM120_DROME reviewed Transmembrane protein 120 homolog CG32795 Drosophila melanogaster (Fruit fly) 387 defense response to Gram-negative bacterium [GO:0050829]; positive regulation of innate immune response [GO:0045089] GO:0016021; GO:0045089; GO:0050829 0 0 0 PF07851; Q9UBV8 CHOYP_LOC100367378.1.1 m.25783 sp PEF1_HUMAN 49.451 182 89 2 48 228 103 282 1.55E-58 189 PEF1_HUMAN reviewed Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) PEF1 ABP32 UNQ1845/PRO3573 Homo sapiens (Human) 284 proteolysis [GO:0006508]; response to calcium ion [GO:0051592] GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0016020; GO:0044822; GO:0046982; GO:0046983; GO:0051592; GO:0070062 0 0 0 PF13405;PF13499; Q9UM22 CHOYP_LOC100329078.3.3 m.31022 sp EPDR1_HUMAN 28.421 190 123 5 36 221 26 206 1.55E-16 78.6 EPDR1_HUMAN reviewed Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; Q9UQ03 CHOYP_LOC658242.1.1 m.41709 sp COR2B_HUMAN 52.451 408 191 1 26 433 13 417 1.55E-160 470 COR2B_HUMAN reviewed Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96) CORO2B KIAA0925 Homo sapiens (Human) 480 actin cytoskeleton organization [GO:0030036] GO:0003779; GO:0005737; GO:0015629; GO:0016020; GO:0030036; GO:0051015 0 0 0 PF08953;PF00400; A4IF63 CHOYP_BRAFLDRAFT_205965.31.43 m.52708 sp TRIM2_BOVIN 24.324 148 104 3 137 282 602 743 1.56E-06 53.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B2RX88 CHOYP_CSPP1.6.14 m.38000 sp CSPP1_MOUSE 30.256 195 107 5 1 184 854 1030 1.56E-13 71.2 CSPP1_MOUSE reviewed Centrosome and spindle pole associated protein 1 Cspp1 Cspp Mus musculus (Mouse) 1205 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 E9Q414 CHOYP_LOC581779.1.1 m.43631 sp APOB_MOUSE 20.056 708 480 22 20 702 379 1025 1.56E-17 92 APOB_MOUSE reviewed Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)] Apob Mus musculus (Mouse) 4505 artery morphogenesis [GO:0048844]; cellular response to prostaglandin stimulus [GO:0071379]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle remodeling [GO:0034374]; nervous system development [GO:0007399]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; post-embryonic development [GO:0009791]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol biosynthetic process [GO:0045540]; response to carbohydrate [GO:0009743]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to virus [GO:0009615]; spermatogenesis [GO:0007283]; sperm motility [GO:0030317]; triglyceride catabolic process [GO:0019433]; triglyceride mobilization [GO:0006642] GO:0001701; GO:0005543; GO:0005576; GO:0005737; GO:0005783; GO:0005794; GO:0005886; GO:0006629; GO:0006642; GO:0006898; GO:0007283; GO:0007399; GO:0008201; GO:0008203; GO:0009566; GO:0009615; GO:0009743; GO:0009791; GO:0010269; GO:0010628; GO:0010744; GO:0010884; GO:0010886; GO:0012506; GO:0015629; GO:0016042; GO:0017127; GO:0019433; GO:0030301; GO:0030317; GO:0031983; GO:0032496; GO:0033344; GO:0034359; GO:0034361; GO:0034362; GO:0034363; GO:0034374; GO:0034383; GO:0035473; GO:0042157; GO:0042158; GO:0042159; GO:0042627; GO:0042632; GO:0042953; GO:0043025; GO:0045540; GO:0048844; GO:0050750; GO:0070062; GO:0071356; GO:0071379 0 0 0 PF12491;PF06448;PF09172;PF01347; O14522 CHOYP_PTPRT.16.45 m.41707 sp PTPRT_HUMAN 30.435 414 236 14 364 735 684 1087 1.56E-46 182 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14657 CHOYP_BRAFLDRAFT_128102.1.1 m.66277 sp TOR1B_HUMAN 44.127 315 170 3 31 344 26 335 1.56E-96 293 TOR1B_HUMAN reviewed Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B) TOR1B DQ1 FKSG18 Homo sapiens (Human) 336 chaperone mediated protein folding requiring cofactor [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763]; protein homooligomerization [GO:0051260]; response to unfolded protein [GO:0006986] GO:0005524; GO:0005635; GO:0005783; GO:0005788; GO:0006986; GO:0007029; GO:0016887; GO:0031965; GO:0051085; GO:0051260; GO:0070062; GO:0071763 0 0 0 PF06309; O43159 CHOYP_LOC100710880.1.1 m.13008 sp RRP8_HUMAN 53.571 224 100 1 367 586 233 456 1.56E-81 266 RRP8_HUMAN reviewed Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) RRP8 KIAA0409 NML hucep-1 Homo sapiens (Human) 456 "cellular response to glucose starvation [GO:0042149]; chromatin silencing at rDNA [GO:0000183]; covalent chromatin modification [GO:0016569]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of cell cycle arrest [GO:0071158]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0000183; GO:0005634; GO:0005654; GO:0005677; GO:0005730; GO:0005737; GO:0005886; GO:0006351; GO:0006364; GO:0008757; GO:0016569; GO:0033553; GO:0035064; GO:0042149; GO:0044822; GO:0046015; GO:0071158; GO:0072332 0 0 0 PF05148; O54750 CHOYP_LOC100701255.1.1 m.29251 sp CP2J6_MOUSE 39.059 489 285 8 3 486 20 500 1.56E-115 352 CP2J6_MOUSE reviewed Cytochrome P450 2J6 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ6) Cyp2j6 Mus musculus (Mouse) 501 arachidonic acid metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; linoleic acid metabolic process [GO:0043651] GO:0005506; GO:0005783; GO:0005789; GO:0008392; GO:0008395; GO:0008404; GO:0008405; GO:0019369; GO:0019373; GO:0020037; GO:0031090; GO:0043651; GO:0070062; GO:0070330; GO:0071614 0 0 0 PF00067; O76202 CHOYP_LOC100893306.1.1 m.38215 sp USP_CHOFU 46 100 54 0 175 274 118 217 1.56E-24 112 USP_CHOFU reviewed Protein ultraspiracle homolog (Nuclear receptor subfamily 2 group B member 4) USP NR2B4 Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana) 472 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; O77302 CHOYP_LOC100708197.1.1 m.66594 sp RS10_LUMRU 79.167 72 15 0 1 72 1 72 1.56E-36 124 RS10_LUMRU reviewed 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) 156 0 GO:0005840 0 0 0 PF03501; O93209 CHOYP_LOC100497926.1.2 m.30154 sp POL_FFV 29.143 175 110 3 41 215 241 401 1.56E-08 60.5 POL_FFV reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Feline foamy virus (FFV) (Feline syncytial virus) 1156 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; P13280 CHOYP_LOC584364.2.2 m.57786 sp GLYG_RABIT 54.79 334 133 5 14 335 6 333 1.56E-124 364 GLYG_RABIT reviewed Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) GYG1 GYG Oryctolagus cuniculus (Rabbit) 333 glycogen biosynthetic process [GO:0005978] GO:0005978; GO:0008466; GO:0046872 PATHWAY: Glycan biosynthesis; glycogen biosynthesis. 0 0 PF01501; P16537 CHOYP_LOC100026365.1.1 m.6217 sp SPC3_STRPU 36.905 84 52 1 69 152 112 194 1.56E-12 68.9 SPC3_STRPU reviewed Protein SPEC3 SPEC3 Strongylocentrotus purpuratus (Purple sea urchin) 208 0 GO:0000139; GO:0005929; GO:0016021 0 0 0 PF15795; P20397 CHOYP_NUCL.1.2 m.19135 sp NUCL_XENLA 41.117 197 95 3 176 372 311 486 1.56E-35 141 NUCL_XENLA reviewed Nucleolin (Protein C23) ncl Xenopus laevis (African clawed frog) 651 0 GO:0000166; GO:0003677; GO:0003723; GO:0005730 0 0 0 PF00076; P23953 CHOYP_CES1D.1.1 m.35316 sp EST1C_MOUSE 32.103 542 303 19 45 566 47 543 1.56E-71 242 EST1C_MOUSE reviewed Carboxylesterase 1C (EC 3.1.1.1) (Liver carboxylesterase N) (Lung surfactant convertase) (PES-N) Ces1c Es1 Mus musculus (Mouse) 554 0 GO:0005615; GO:0005788; GO:0016788; GO:0052689 0 0 0 PF00135; P25107 CHOYP_PTH1R.4.4 m.65130 sp PTH1R_DIDVI 33.714 525 299 11 19 509 72 581 1.56E-87 284 PTH1R_DIDVI reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) 585 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166] GO:0004991; GO:0005887; GO:0007166; GO:0007188; GO:0017046; GO:0043621 0 0 0 PF00002;PF02793; P35248 CHOYP_COBA1.1.1 m.63079 sp SFTPD_RAT 49.074 108 49 1 79 180 63 170 1.56E-14 74.3 SFTPD_RAT reviewed Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (CP4) (Lung surfactant protein D) Sftpd Sftp4 Rattus norvegicus (Rat) 374 innate immune response [GO:0045087]; lung alveolus development [GO:0048286]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of phagocytosis [GO:0050765]; negative regulation of T cell proliferation [GO:0042130]; opsonization [GO:0008228]; positive regulation of phagocytosis [GO:0050766]; regulation of liquid surface tension [GO:0050828]; respiratory gaseous exchange [GO:0007585]; response to corticosteroid [GO:0031960]; response to glucocorticoid [GO:0051384]; response to growth factor [GO:0070848]; response to hyperoxia [GO:0055093]; surfactant homeostasis [GO:0043129] GO:0001530; GO:0005578; GO:0005581; GO:0005615; GO:0005771; GO:0005791; GO:0007585; GO:0008228; GO:0031410; GO:0031960; GO:0032703; GO:0042130; GO:0042802; GO:0043129; GO:0045087; GO:0048029; GO:0048286; GO:0050765; GO:0050766; GO:0050828; GO:0051384; GO:0055093; GO:0070848 0 0 0 PF01391;PF00059;PF09006; P48159 CHOYP_RL23.10.11 m.65116 sp RL23_DROME 94.318 88 5 0 1 88 52 139 1.56E-55 171 RL23_DROME reviewed 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) 140 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0006412; GO:0007052; GO:0017022; GO:0022008; GO:0022625; GO:0070180 0 0 0 PF00238; P48545 CHOYP_LOC100749745.1.1 m.11523 sp KCNJ5_MOUSE 38.636 352 208 3 19 370 27 370 1.56E-84 268 KCNJ5_MOUSE reviewed "G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)" Kcnj5 Girk4 Mus musculus (Mouse) 419 potassium ion import [GO:0010107] GO:0005242; GO:0005887; GO:0009897; GO:0010107; GO:0015467; GO:0030315 0 0 0 PF01007; P50607 CHOYP_LOC101063890.1.1 m.7895 sp TUB_HUMAN 72.201 259 66 2 363 615 248 506 1.56E-142 426 TUB_HUMAN reviewed Tubby protein homolog TUB Homo sapiens (Human) 506 "phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to nonmotile primary cilium [GO:0097500]; response to hormone [GO:0009725]; retina development in camera-type eye [GO:0060041]; sensory perception of sound [GO:0007605]" GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005929; GO:0006910; GO:0007605; GO:0009725; GO:0032403; GO:0035091; GO:0045494; GO:0050766; GO:0060041; GO:0097500; GO:1903546 0 0 0 PF01167;PF16322; P54145 CHOYP_NEMVEDRAFT_V1G173932.3.3 m.57619 sp AMT1_CAEEL 33.663 404 237 11 22 406 43 434 1.56E-50 182 AMT1_CAEEL reviewed Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans 534 ammonium transmembrane transport [GO:0072488]; nitrogen utilization [GO:0019740]; organic cation transport [GO:0015695] GO:0005887; GO:0008519; GO:0015695; GO:0019740; GO:0072488 0 0 0 PF00909; Q03601 CHOYP_BRAFLDRAFT_205965.10.43 m.20536 sp NHL1_CAEEL 30.357 112 66 4 155 257 772 880 1.56E-06 52.8 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q0IH86 CHOYP_LOC100374532.1.1 m.18925 sp SLX1_XENLA 51.93 285 127 3 13 296 3 278 1.56E-98 294 SLX1_XENLA reviewed Structure-specific endonuclease subunit slx1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1) slx1a giyd1 slx1 Xenopus laevis (African clawed frog) 282 DNA recombination [GO:0006310]; DNA repair [GO:0006281] GO:0006281; GO:0006310; GO:0017108; GO:0033557; GO:0046872 0 0 0 PF01541; Q12955 CHOYP_LOC100641396.9.27 m.33056 sp ANK3_HUMAN 27.047 806 460 28 182 916 42 790 1.56E-52 204 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q16994 CHOYP_CD36_83030.4.4 m.58370 sp FMR2_ANTEL 32.857 140 94 0 3 142 194 333 1.56E-12 68.2 FMR2_ANTEL reviewed Antho-RFamide neuropeptides type 2 [Cleaved into: Antho-RFamide] 0 Anthopleura elegantissima (Sea anemone) 429 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF01581; Q18PD9 CHOYP_DOK7.1.1 m.35964 sp DOK7_TAKRU 37.313 201 123 1 23 223 5 202 1.56E-36 149 DOK7_TAKRU reviewed Protein Dok-7 (Downstream of tyrosine kinase 7) dok7 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 502 0 GO:0005886; GO:0008289; GO:0030054; GO:0045202 0 0 0 PF02174; Q24895 CHOYP_BRAFLDRAFT_125387.1.2 m.21902 sp GRP78_ECHMU 43.452 168 91 1 1 164 460 627 1.56E-36 138 GRP78_ECHMU reviewed 78 kDa glucose-regulated protein (GRP-78) GRP78 Echinococcus multilocularis (Fox tapeworm) 649 0 GO:0005524; GO:0005788 0 0 0 PF00012; Q28IV8 CHOYP_LOC100374036.1.1 m.65939 sp NGDN_XENTR 46.763 278 133 3 4 268 10 285 1.56E-76 248 NGDN_XENTR reviewed Neuroguidin (EIF4E-binding protein) ngdn TNeu114c02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 316 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of translation [GO:0006417]" GO:0000462; GO:0005730; GO:0005737; GO:0006417; GO:0032040 0 0 0 PF04000; Q29H56 CHOYP_LOC100377311.8.14 m.37669 sp MAB21_DROPS 36.735 98 60 2 9 105 252 348 1.56E-10 64.7 MAB21_DROPS reviewed Protein mab-21 mab-21 GA18400 Drosophila pseudoobscura pseudoobscura (Fruit fly) 365 0 0 0 0 0 PF03281; Q3S8M4 CHOYP_ELOV4.2.3 m.52285 sp ELOV4_MACMU 52.365 296 130 1 1 296 12 296 1.56E-110 325 ELOV4_MACMU reviewed Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) ELOVL4 Macaca mulatta (Rhesus macaque) 314 "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" GO:0005783; GO:0006636; GO:0009922; GO:0019367; GO:0030148; GO:0030176; GO:0034625; GO:0034626; GO:0035338; GO:0042761; GO:0102336; GO:0102337; GO:0102338 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03204}. 0 0 PF01151; Q3UPF5 CHOYP_LOC100496973.6.8 m.57925 sp ZCCHV_MOUSE 30.502 259 142 14 51 295 1 235 1.56E-17 91.7 ZCCHV_MOUSE reviewed Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) Zc3hav1 Mus musculus (Mouse) 946 cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of ATPase activity [GO:0032781]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; regulation of defense response to virus by host [GO:0050691]; response to virus [GO:0009615]; suppression by virus of host molecular function [GO:0039507] GO:0003950; GO:0005634; GO:0005737; GO:0005764; GO:0005770; GO:0005794; GO:0009615; GO:0017151; GO:0032481; GO:0032727; GO:0032728; GO:0032781; GO:0039507; GO:0043123; GO:0044822; GO:0045071; GO:0045087; GO:0046872; GO:0050691; GO:0051607; GO:0061014; GO:0071360; GO:1900246 0 0 0 PF00644;PF02825; Q53P85 CHOYP_LOC100186906.1.1 m.45253 sp CDPKO_ORYSJ 38.158 76 44 1 83 155 343 418 1.56E-09 63.9 CDPKO_ORYSJ reviewed Calcium-dependent protein kinase 24 (OsCDPK24) (OsCPK24) (EC 2.7.11.1) (Calcium-dependent protein kinase OsCDPK14) CPK24 Os11g0171500 LOC_Os11g07040 OsJ_33123 Oryza sativa subsp. japonica (Rice) 513 abscisic acid-activated signaling pathway [GO:0009738]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0009738; GO:0009931; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; Q5R9I4 CHOYP_PHUM_PHUM470860.1.1 m.14098 sp TV23B_PONAB 48.469 196 98 2 2 194 9 204 1.56E-68 211 TV23B_PONAB reviewed Golgi apparatus membrane protein TVP23 homolog B TVP23B FAM18B FAM18B1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 205 0 GO:0016021 0 0 0 PF05832; Q60431 CHOYP_LOC100695417.2.2 m.52789 sp CASP3_MESAU 33.533 167 86 6 48 213 37 179 1.56E-15 79 CASP3_MESAU reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q61470 CHOYP_contig_045503 m.52950 sp CD37_MOUSE 26.471 102 75 0 85 186 60 161 1.56E-07 55.5 CD37_MOUSE reviewed Leukocyte antigen CD37 (CD antigen CD37) Cd37 Mus musculus (Mouse) 281 cell surface receptor signaling pathway [GO:0007166]; defense response to protozoan [GO:0042832]; negative regulation of cell proliferation [GO:0008285]; negative regulation of myeloid dendritic cell activation [GO:0030886]; positive regulation of immunoglobulin production [GO:0002639]; regulation of defense response to virus [GO:0050688]; regulation of humoral immune response [GO:0002920] GO:0001772; GO:0002639; GO:0002920; GO:0005887; GO:0007166; GO:0008285; GO:0016020; GO:0030886; GO:0042832; GO:0050688; GO:0070062 0 0 0 PF00335; Q642M9 CHOYP_DVIR_GJ22204.1.1 m.17270 sp DHDH_DANRE 40.979 327 193 0 34 360 1 327 1.56E-80 252 DHDH_DANRE reviewed "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh ch211-203b17.3 zgc:101723 Danio rerio (Zebrafish) (Brachydanio rerio) 334 D-xylose catabolic process [GO:0042843] GO:0042843; GO:0047115; GO:0047837 0 0 0 PF01408; Q6DC77 CHOYP_MPRGB.2.2 m.60370 sp MPRGB_DANRE 47.239 326 153 3 29 336 10 334 1.56E-97 300 MPRGB_DANRE reviewed Membrane progestin receptor gamma-B (mPR gamma-B) (Progestin and adipoQ receptor family member V-B) paqr5b zgc:101065 Danio rerio (Zebrafish) (Brachydanio rerio) 347 multicellular organism development [GO:0007275]; oogenesis [GO:0048477]; response to steroid hormone [GO:0048545] GO:0003707; GO:0005496; GO:0005886; GO:0007275; GO:0016021; GO:0048477; GO:0048545 0 0 0 PF03006; Q6NYU7 CHOYP_LOC100161158.1.1 m.14383 sp UPP_DANRE 64.706 221 74 1 2 222 41 257 1.56E-108 315 UPP_DANRE reviewed Uracil phosphoribosyltransferase homolog uprt zgc:77421 Danio rerio (Zebrafish) (Brachydanio rerio) 257 nucleoside metabolic process [GO:0009116] GO:0005525; GO:0005634; GO:0005737; GO:0009116 0 0 cd06223; PF14681; Q6P2X9 CHOYP_LOC100883709.2.2 m.55976 sp MOT12_XENTR 25.41 488 302 7 5 487 12 442 1.56E-40 155 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6PJ21 CHOYP_SPSB3.1.1 m.32225 sp SPSB3_HUMAN 48.973 292 137 1 45 324 62 353 1.56E-99 300 SPSB3_HUMAN reviewed SPRY domain-containing SOCS box protein 3 (SSB-3) SPSB3 C16orf31 SSB3 Homo sapiens (Human) 355 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622; Q6ZRF8 CHOYP_BRAFLDRAFT_80400.3.4 m.32760 sp RN207_HUMAN 29.31 116 75 5 16 129 103 213 1.56E-07 52.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7Z0T3 CHOYP_TEMPT.2.3 m.39578 sp TEMPT_APLCA 37.121 132 66 8 2 130 5 122 1.56E-09 56.2 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q801E2 CHOYP_LOC100184096.1.1 m.59402 sp ANLN_XENLA 26.86 242 92 8 24 200 1 222 1.56E-09 60.5 ANLN_XENLA reviewed Actin-binding protein anillin anln Xenopus laevis (African clawed frog) 1116 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0005856; GO:0005938; GO:0007067; GO:0051301 0 0 0 PF08174;PF16018;PF00169; Q8BHN5 CHOYP_LOC412116.1.1 m.42829 sp RBM45_MOUSE 33.151 549 251 11 29 557 22 474 1.56E-89 286 RBM45_MOUSE reviewed RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) Rbm45 Drb1 Drbp1 Mus musculus (Mouse) 476 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0007399; GO:0030154; GO:0044822 0 0 0 PF00076; Q8BSY0 CHOYP_ASPH.1.2 m.35319 sp ASPH_MOUSE 53.465 404 185 3 586 988 340 741 1.56E-146 456 ASPH_MOUSE reviewed Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase) Asph Bah Mus musculus (Mouse) 741 "activation of cysteine-type endopeptidase activity [GO:0097202]; activation of store-operated calcium channel activity [GO:0032237]; calcium ion transmembrane transport [GO:0070588]; cellular response to calcium ion [GO:0071277]; face morphogenesis [GO:0060325]; limb morphogenesis [GO:0035108]; negative regulation of cell proliferation [GO:0008285]; palate development [GO:0060021]; pattern specification process [GO:0007389]; peptidyl-aspartic acid hydroxylation [GO:0042264]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteolysis [GO:0045862]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585]; regulation of protein depolymerization [GO:1901879]; regulation of protein stability [GO:0031647]; response to ATP [GO:0033198]" GO:0004597; GO:0005509; GO:0005737; GO:0005783; GO:0005886; GO:0007389; GO:0008285; GO:0010524; GO:0016021; GO:0030176; GO:0031585; GO:0031647; GO:0032237; GO:0032541; GO:0033017; GO:0033198; GO:0035108; GO:0042264; GO:0045862; GO:0045893; GO:0060021; GO:0060325; GO:0070588; GO:0071277; GO:0090316; GO:0097202; GO:1901879 0 0 0 PF05279;PF05118; Q8BW74 CHOYP_HLF.1.2 m.10674 sp HLF_MOUSE 46.377 276 115 10 11 257 21 292 1.56E-60 196 HLF_MOUSE reviewed Hepatic leukemia factor Hlf Mus musculus (Mouse) 295 rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914] GO:0000977; GO:0001077; GO:0005634; GO:0035914; GO:0048511 0 0 0 PF07716; Q8BW74 CHOYP_HLF.2.2 m.11792 sp HLF_MOUSE 46.377 276 115 10 11 257 21 292 1.56E-60 196 HLF_MOUSE reviewed Hepatic leukemia factor Hlf Mus musculus (Mouse) 295 rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914] GO:0000977; GO:0001077; GO:0005634; GO:0035914; GO:0048511 0 0 0 PF07716; Q8K1J5 CHOYP_BRAFLDRAFT_120767.1.1 m.16005 sp SDE2_MOUSE 37.47 411 195 9 18 375 47 448 1.56E-69 228 SDE2_MOUSE reviewed Protein SDE2 homolog Sde2 Mus musculus (Mouse) 448 0 GO:0005634 0 0 0 PF13019; Q8TCT0 CHOYP_LOC101167008.2.2 m.58615 sp CERK1_HUMAN 31.25 240 161 3 54 289 81 320 1.56E-35 141 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q90879 CHOYP_DWIL_GK17319.1.1 m.58968 sp UB2V1_CHICK 57.042 142 61 0 14 155 2 143 1.56E-60 186 UB2V1_CHICK reviewed Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1B) UBE2V1 Gallus gallus (Chicken) 145 positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534] GO:0000151; GO:0005634; GO:0005737; GO:0006301; GO:0031625; GO:0035370; GO:0043123; GO:0051092; GO:0061630; GO:0070062; GO:0070534 0 0 0 PF00179; Q99719 CHOYP_SEPT5.2.2 m.44820 sp SEPT5_HUMAN 62.254 355 130 3 68 420 15 367 1.56E-164 470 SEPT5_HUMAN reviewed Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1) SEPT5 PNUTL1 Homo sapiens (Human) 369 cytokinesis [GO:0000910]; positive regulation of exocytosis [GO:0045921]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle targeting [GO:0016080] GO:0000910; GO:0003924; GO:0005198; GO:0005525; GO:0005856; GO:0005886; GO:0005938; GO:0008021; GO:0016080; GO:0017157; GO:0043195; GO:0045921; GO:2000300 0 0 cd01850; PF00735; Q99941 CHOYP_LOC100693055.1.1 m.10348 sp ATF6B_HUMAN 32.703 370 219 9 187 530 315 680 1.56E-46 176 ATF6B_HUMAN reviewed Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta] ATF6B CREBL1 G13 Homo sapiens (Human) 703 "ATF6-mediated unfolded protein response [GO:0036500]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005622; GO:0005634; GO:0005789; GO:0005794; GO:0006351; GO:0007165; GO:0030176; GO:0032993; GO:0035497; GO:0036500; GO:0043565; GO:0044212; GO:1990440 0 0 0 PF00170; Q9BXT4 CHOYP_LOC100210185.1.1 m.28731 sp TDRD1_HUMAN 23.723 548 357 15 2 522 335 848 1.56E-30 134 TDRD1_HUMAN reviewed Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1) TDRD1 Homo sapiens (Human) 1180 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0005737; GO:0007275; GO:0007281; GO:0007283; GO:0031047; GO:0033391; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; Q9D5V6 CHOYP_LOC574928.1.2 m.48221 sp SYAP1_MOUSE 44.892 372 152 12 1 347 1 344 1.56E-82 258 SYAP1_MOUSE reviewed Synapse-associated protein 1 Syap1 Mus musculus (Mouse) 365 0 GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0070062 0 0 0 PF03909; Q9ER88 CHOYP_ND1.4.5 m.42588 sp RT29_MOUSE 35.655 359 226 3 33 389 36 391 1.56E-80 255 RT29_MOUSE reviewed "28S ribosomal protein S29, mitochondrial (MRP-S29) (S29mt) (Death-associated protein 3) (DAP-3)" Dap3 Mrps29 Mus musculus (Mouse) 391 apoptotic mitochondrial changes [GO:0008637] GO:0003735; GO:0005654; GO:0005739; GO:0005759; GO:0005763; GO:0008637; GO:0044822 0 0 0 PF10236; Q9H1D9 CHOYP_RPC6.1.2 m.10259 sp RPC6_HUMAN 66.772 316 101 2 1 312 1 316 1.56E-159 450 RPC6_HUMAN reviewed DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39) POLR3F Homo sapiens (Human) 316 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of type I interferon production [GO:0032481]; regulation of transcription from RNA polymerase III promoter [GO:0006359]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003899; GO:0005654; GO:0005666; GO:0005829; GO:0006359; GO:0006383; GO:0032481; GO:0032728; GO:0045087; GO:0045089; GO:0051607 0 0 0 PF05158; Q9WUM3 CHOYP_SMP_012720.2.2 m.34968 sp COR1B_MOUSE 50.299 501 225 9 1 495 1 483 1.56E-177 510 COR1B_MOUSE reviewed Coronin-1B (Coronin-2) Coro1b Mus musculus (Mouse) 484 actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; cell migration [GO:0016477]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; endothelial cell chemotaxis [GO:0035767]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; positive regulation of lamellipodium morphogenesis [GO:2000394]; protein localization to cell leading edge [GO:1902463]; ruffle organization [GO:0031529]; wound healing [GO:0042060] GO:0001725; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005925; GO:0015629; GO:0016477; GO:0030027; GO:0030036; GO:0031252; GO:0031529; GO:0034316; GO:0035767; GO:0036120; GO:0042060; GO:0042802; GO:0048471; GO:0051015; GO:0051017; GO:0070062; GO:0071672; GO:0071933; GO:0071944; GO:0090135; GO:1902463; GO:2000394 0 0 0 PF08953;PF00400; Q9XZC0 CHOYP_BRAFLDRAFT_122957.1.1 m.7668 sp LCTA_LATTR 28.667 150 91 4 165 304 786 929 1.56E-06 55.1 LCTA_LATTR reviewed Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1) (Fragment) 0 Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) 1413 exocytosis [GO:0006887] GO:0005576; GO:0006887; GO:0016021; GO:0072556 0 0 0 PF12796;PF13606; Q9Y5B0 CHOYP_PHUM_PHUM378040.1.1 m.15341 sp CTDP1_HUMAN 48.466 326 138 6 6 304 12 334 1.56E-94 320 CTDP1_HUMAN reviewed RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase) CTDP1 FCP1 Homo sapiens (Human) 961 cell division [GO:0051301]; dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; exit from mitosis [GO:0010458]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; positive regulation of viral transcription [GO:0050434]; protein dephosphorylation [GO:0006470]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000922; GO:0004721; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0006366; GO:0006368; GO:0006470; GO:0008420; GO:0010458; GO:0015629; GO:0016591; GO:0030496; GO:0050434; GO:0051233; GO:0051301; GO:0061052; GO:0070940 0 0 0 PF09309;PF03031; Q9Z0L8 CHOYP_ZGC_171566.1.1 m.22181 sp GGH_MOUSE 49.821 279 129 7 23 298 33 303 1.56E-86 265 GGH_MOUSE reviewed Gamma-glutamyl hydrolase (EC 3.4.19.9) (Conjugase) (FGPH) (Folylpolyglutamate hydrolase) (GH) (Gamma-Glu-x carboxypeptidase) Ggh Mus musculus (Mouse) 317 glutamine metabolic process [GO:0006541]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to zinc ion [GO:0010043]; tetrahydrofolylpolyglutamate metabolic process [GO:0046900] GO:0005615; GO:0005634; GO:0005764; GO:0005829; GO:0006541; GO:0010043; GO:0032868; GO:0034722; GO:0042470; GO:0042493; GO:0045471; GO:0046900; GO:0070062 0 0 0 PF07722; A5PKK7 CHOYP_GORAB.1.2 m.23390 sp GORAB_BOVIN 38.618 246 111 6 154 376 54 282 1.57E-37 145 GORAB_BOVIN reviewed RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) GORAB SCYL1BP1 Bos taurus (Bovine) 370 0 GO:0005794 0 0 0 PF04949; C3KJF2 CHOYP_SWI5.1.2 m.26939 sp SWI5_ANOFI 46.875 96 46 1 17 112 46 136 1.57E-22 88.2 SWI5_ANOFI reviewed DNA repair protein SWI5 homolog (Protein SAE3 homolog) swi5 sae3 Anoplopoma fimbria (Sablefish) 136 double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0005634; GO:0032798 0 0 0 PF07061; D2GXS7 CHOYP_contig_020766 m.23924 sp TRIM2_AILME 33.636 110 65 4 5 109 626 732 1.57E-08 55.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YWJ0 CHOYP_SLIP.1.1 m.35984 sp SLIP_MOUSE 34.307 137 83 2 3 134 232 366 1.57E-14 82 SLIP_MOUSE reviewed Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center) Nuggc Mus musculus (Mouse) 796 cellular response to DNA damage stimulus [GO:0006974]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0005525; GO:0005634; GO:0006974; GO:0016446; GO:0016607; GO:0016787 0 0 0 PF00350; D3YXG0 CHOYP_AGAP_AGAP010742.1.1 m.51062 sp HMCN1_MOUSE 27.358 318 182 13 4 285 2751 3055 1.57E-15 84.7 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D3ZQG6 CHOYP_TRIM3.58.58 m.66887 sp TRIM2_RAT 23.77 244 172 7 42 281 499 732 1.57E-06 52.8 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E1BLP6 CHOYP_H6.1.1 m.52362 sp ARI5B_BOVIN 43.396 424 199 10 1 392 1 415 1.57E-96 332 ARI5B_BOVIN reviewed AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) ARID5B Bos taurus (Bovine) 1173 "adipose tissue development [GO:0060612]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006357; GO:0044212; GO:0051091; GO:0060612 0 0 0 PF01388; E9Q555 CHOYP_RN213.7.13 m.45976 sp RN213_MOUSE 26.033 1041 684 34 77 1079 3475 4467 1.57E-84 305 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O43301 CHOYP_BRAFLDRAFT_208197.20.21 m.61262 sp HS12A_HUMAN 28.896 661 378 21 193 778 21 664 1.57E-78 270 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O70244 CHOYP_CUBN.6.7 m.62191 sp CUBN_RAT 26.225 408 248 18 7 372 1335 1731 1.57E-13 78.6 CUBN_RAT reviewed Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) 3623 cholesterol metabolic process [GO:0008203]; cobalamin transport [GO:0015889]; hemoglobin import [GO:0020028]; in utero embryonic development [GO:0001701]; protein homotrimerization [GO:0070207]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to nutrient [GO:0007584]; vitamin metabolic process [GO:0006766] GO:0001701; GO:0004872; GO:0005509; GO:0005765; GO:0005905; GO:0006766; GO:0006898; GO:0007584; GO:0008203; GO:0010008; GO:0015031; GO:0015235; GO:0015889; GO:0016020; GO:0020028; GO:0030135; GO:0030492; GO:0030666; GO:0031419; GO:0031526; GO:0042802; GO:0043202; GO:0043234; GO:0070207 0 0 0 PF00431;PF00008;PF12947;PF07645; O75095 CHOYP_SREC2.3.9 m.33172 sp MEGF6_HUMAN 38.667 225 119 10 31 252 776 984 1.57E-30 126 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75382 CHOYP_BRAFLDRAFT_87286.1.1 m.32683 sp TRIM3_HUMAN 26.829 123 87 2 121 241 622 743 1.57E-07 55.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02711 CHOYP_LOC100465858.1.1 m.37023 sp ACHA_TORMA 25.342 438 276 12 20 412 12 443 1.57E-38 147 ACHA_TORMA reviewed Acetylcholine receptor subunit alpha CHRNA1 Torpedo marmorata (Marbled electric ray) 461 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; P12074 CHOYP_CX6A2.1.1 m.47963 sp CX6A1_HUMAN 37.647 85 48 3 35 115 23 106 1.57E-09 54.7 CX6A1_HUMAN reviewed "Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L)" COX6A1 COX6AL Homo sapiens (Human) 109 "generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" GO:0004129; GO:0005743; GO:0005751; GO:0006091; GO:0006123 0 0 0 PF02046; P18754 CHOYP_RCC1.1.1 m.15249 sp RCC1_HUMAN 51.493 402 188 6 42 440 20 417 1.57E-138 406 RCC1_HUMAN reviewed Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) RCC1 CHC1 Homo sapiens (Human) 421 cell division [GO:0051301]; chromosome segregation [GO:0007059]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]; viral process [GO:0016032] GO:0000082; GO:0000790; GO:0000794; GO:0003682; GO:0005087; GO:0005634; GO:0005654; GO:0005737; GO:0007052; GO:0007059; GO:0007067; GO:0007088; GO:0016032; GO:0031492; GO:0031965; GO:0042393; GO:0051225; GO:0051301 0 0 0 PF00415; P22105 CHOYP_LOC579946.7.24 m.39737 sp TENX_HUMAN 29.402 619 312 51 89 650 200 750 1.57E-31 138 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P27546 CHOYP_ISCW_ISCW011253.1.1 m.66926 sp MAP4_MOUSE 47.664 107 50 4 41 141 966 1072 1.57E-17 81.3 MAP4_MOUSE reviewed Microtubule-associated protein 4 (MAP-4) Map4 Mtap4 Mus musculus (Mouse) 1125 cell division [GO:0051301]; establishment of spindle orientation [GO:0051294]; microtubule sliding [GO:0051012]; mitotic spindle organization [GO:0007052]; negative regulation of nonmotile primary cilium assembly [GO:1902856]; neuron projection development [GO:0031175] GO:0005737; GO:0005874; GO:0005875; GO:0005886; GO:0005930; GO:0007052; GO:0008017; GO:0014069; GO:0015630; GO:0031175; GO:0043005; GO:0044822; GO:0051012; GO:0051294; GO:0051301; GO:0070062; GO:0072686; GO:1902856 0 0 0 PF00418; P31228 CHOYP_OXDD.1.4 m.2688 sp OXDD_BOVIN 41.033 329 187 4 3 328 5 329 1.57E-80 251 OXDD_BOVIN reviewed D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Bos taurus (Bovine) 341 D-amino acid metabolic process [GO:0046416] GO:0005777; GO:0008445; GO:0046416; GO:0071949 0 0 0 PF01266; P32100 CHOYP_RPL7.1.2 m.5541 sp RL7_DROME 74.074 162 41 1 22 182 91 252 1.57E-85 254 RL7_DROME reviewed 60S ribosomal protein L7 RpL7 CG4897 Drosophila melanogaster (Fruit fly) 252 "centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; pupariation [GO:0035073]" GO:0000022; GO:0000463; GO:0002181; GO:0003735; GO:0005840; GO:0007052; GO:0022625; GO:0035073; GO:0044822; GO:0051298 0 0 0 PF00327;PF08079; P38552 CHOYP_LEG8.1.2 m.25641 sp LEG4_RAT 40.458 131 74 3 5 133 16 144 1.57E-24 99 LEG4_RAT reviewed Galectin-4 (Gal-4) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) Lgals4 Rattus norvegicus (Rat) 324 0 GO:0005615; GO:0016936; GO:0030246 0 0 0 PF00337; P83425 CHOYP_BRAFLDRAFT_89395.3.3 m.64215 sp HIP_MYTED 27.82 133 85 4 58 184 85 212 1.57E-07 52.8 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P83425 CHOYP_LOC100698726.2.8 m.5210 sp HIP_MYTED 28.916 166 113 3 111 275 51 212 1.57E-08 57 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q02357 CHOYP_PMAA_071020.1.1 m.20646 sp ANK1_MOUSE 29.215 777 483 26 21 764 12 754 1.57E-51 198 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q02369 CHOYP_NDUFB9.1.2 m.37494 sp NDUB9_BOVIN 45.833 120 54 5 34 146 8 123 1.57E-22 92.4 NDUB9_BOVIN reviewed NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (Complex I-B22) (CI-B22) (NADH-ubiquinone oxidoreductase B22 subunit) NDUFB9 UQOR22 Bos taurus (Bovine) 179 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitophagy in response to mitochondrial depolarization [GO:0098779]" GO:0005747; GO:0006120; GO:0008137; GO:0070062; GO:0098779 0 0 0 PF05347; Q07352 CHOYP_BRAFLDRAFT_99019.8.8 m.62208 sp TISB_HUMAN 78.125 96 20 1 65 159 88 183 1.57E-47 167 TISB_HUMAN reviewed "Zinc finger protein 36, C3H1 type-like 1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (Protein TIS11B)" ZFP36L1 BERG36 BRF1 ERF1 RNF162B TIS11B Homo sapiens (Human) 338 "3'-UTR-mediated mRNA destabilization [GO:0061158]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to raffinose [GO:0097403]; cellular response to salt stress [GO:0071472]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chorio-allantoic fusion [GO:0060710]; ERK1 and ERK2 cascade [GO:0070371]; heart development [GO:0007507]; MAPK cascade [GO:0000165]; mesendoderm development [GO:0048382]; mRNA transport [GO:0051028]; multicellular organism growth [GO:0035264]; negative regulation of erythrocyte differentiation [GO:0045647]; neural tube development [GO:0021915]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; p38MAPK cascade [GO:0038066]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of monocyte differentiation [GO:0045657]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; proepicardium development [GO:0003342]; protein kinase B signaling [GO:0043491]; regulation of gene expression [GO:0010468]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of mRNA stability [GO:0043488]; regulation of myoblast differentiation [GO:0045661]; regulation of stem cell proliferation [GO:0072091]; response to wounding [GO:0009611]; spongiotrophoblast layer development [GO:0060712]; T cell differentiation in thymus [GO:0033077]; vasculogenesis [GO:0001570]" GO:0000165; GO:0000288; GO:0000932; GO:0001570; GO:0003342; GO:0003677; GO:0003700; GO:0003729; GO:0003730; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007507; GO:0008283; GO:0009611; GO:0010468; GO:0010837; GO:0014065; GO:0021915; GO:0030529; GO:0031086; GO:0031440; GO:0032869; GO:0033077; GO:0035264; GO:0035925; GO:0038066; GO:0043488; GO:0043491; GO:0044344; GO:0044822; GO:0045600; GO:0045616; GO:0045647; GO:0045657; GO:0045661; GO:0046872; GO:0048382; GO:0051028; GO:0060710; GO:0060712; GO:0061158; GO:0070371; GO:0071320; GO:0071356; GO:0071364; GO:0071375; GO:0071385; GO:0071456; GO:0071472; GO:0071560; GO:0071889; GO:0072091; GO:0097403; GO:1900153; GO:1902172; GO:1904582; GO:1904628 0 0 0 PF04553;PF00642; Q09024 CHOYP_PHUM_PHUM494500.1.1 m.9430 sp IMPL2_DROME 29.756 205 119 6 60 264 83 262 1.57E-20 91.3 IMPL2_DROME reviewed Neural/ectodermal development factor IMP-L2 ImpL2 CG15009 Drosophila melanogaster (Fruit fly) 267 cell adhesion [GO:0007155]; determination of adult lifespan [GO:0008340]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lipid storage [GO:0010888]; positive regulation of insulin receptor signaling pathway [GO:0046628] GO:0005520; GO:0005615; GO:0007155; GO:0008340; GO:0010888; GO:0046627; GO:0046628 0 0 0 PF07679; Q0IHH1 CHOYP_NAA30.1.1 m.50680 sp NAA30_XENLA 80.864 162 27 1 129 290 116 273 1.57E-89 270 NAA30_XENLA reviewed N-alpha-acetyltransferase 30 (EC 2.3.1.88) (N-acetyltransferase 12) (N-acetyltransferase MAK3 homolog) (NatC catalytic subunit) naa30 mak3 nat12 Xenopus laevis (African clawed frog) 273 0 GO:0004596; GO:0005737; GO:0031417 0 0 0 PF00583; Q24180 CHOYP_TTC3.1.1 m.7749 sp DEAF1_DROME 43.75 80 44 1 67 146 213 291 1.57E-12 75.1 DEAF1_DROME reviewed Deformed epidermal autoregulatory factor 1 (Protein DEAF-1) Deaf1 CG8567 Drosophila melanogaster (Fruit fly) 576 "embryo development ending in birth or egg hatching [GO:0009792]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of immune response [GO:0050776]; regulation of multicellular organismal development [GO:2000026]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005700; GO:0006351; GO:0006357; GO:0008270; GO:0009792; GO:0043565; GO:0045893; GO:0050776; GO:2000026 0 0 0 PF01342;PF01753; Q24372 CHOYP_SMP_174040.3.3 m.63863 sp LACH_DROME 32.517 286 165 8 66 345 59 322 1.57E-34 136 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q3SX45 CHOYP_LOC100639010.6.9 m.46636 sp ASB2_BOVIN 37.405 131 82 0 4 134 203 333 1.57E-22 95.1 ASB2_BOVIN reviewed Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) 633 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q3UFB2 CHOYP_LOC100767047.1.1 m.56814 sp BCD1_MOUSE 48.261 230 116 3 6 234 209 436 1.57E-68 221 BCD1_MOUSE reviewed Box C/D snoRNA protein 1 (Zinc finger HIT domain-containing protein 6) Znhit6 Bcd1 Mus musculus (Mouse) 460 box C/D snoRNP assembly [GO:0000492]; protein oligomerization [GO:0051259]; ribosome biogenesis [GO:0042254]; snoRNA localization [GO:0048254] GO:0000492; GO:0001094; GO:0019899; GO:0042254; GO:0042802; GO:0046872; GO:0048254; GO:0051117; GO:0051259; GO:0070062; GO:0070761 0 0 0 PF04438; Q3ZBG9 CHOYP_PLS2.1.1 m.25963 sp PLS2_BOVIN 42.412 257 135 5 3 250 41 293 1.57E-63 203 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q4UMH6 CHOYP_AASI_1435.31.35 m.62034 sp Y381_RICFE 29.235 366 209 15 256 619 799 1116 1.57E-19 97.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q53G44 CHOYP_SI_CH211-197G15.7.3.3 m.61063 sp IF44L_HUMAN 32.731 443 260 8 53 490 26 435 1.57E-55 195 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q54468 CHOYP_NEMVEDRAFT_V1G241973.2.2 m.11390 sp CHB_SERMA 39.672 305 151 7 1 291 597 882 1.57E-57 201 CHB_SERMA reviewed Chitobiase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) chb Serratia marcescens 885 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0030247; GO:0042597 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; Q5ND28 CHOYP_MEG10.13.91 m.21940 sp SREC_MOUSE 36.022 186 108 6 4 187 254 430 1.57E-22 102 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5R611 CHOYP_BRAFLDRAFT_119296.3.16 m.9601 sp HRSL3_PONAB 33.333 168 104 3 11 177 2 162 1.57E-21 89 HRSL3_PONAB reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) PLA2G16 HRASLS3 HREV107 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 162 lipid catabolic process [GO:0016042] GO:0004623; GO:0008970; GO:0016021; GO:0016042; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; Q5ZJD7 CHOYP_EXO1.2.2 m.64759 sp YIPF4_CHICK 61.088 239 89 2 37 275 15 249 1.57E-98 291 YIPF4_CHICK reviewed Protein YIPF4 (YIP1 family member 4) YIPF4 RCJMB04_19b22 Gallus gallus (Chicken) 249 0 GO:0005783; GO:0005794; GO:0005886; GO:0016021 0 0 0 PF04893; Q5ZKJ5 CHOYP_LOC100486607.1.1 m.30407 sp MF13A_CHICK 28.931 159 109 3 31 186 329 486 1.57E-14 74.3 MF13A_CHICK reviewed Transmembrane protein 180 (Major facilitator superfamily domain-containing 13A) MFSD13A TMEM180 RCJMB04_10g6 Gallus gallus (Chicken) 509 0 GO:0016021 0 0 0 0 Q61686 CHOYP_CBX1.2.4 m.16625 sp CBX5_MOUSE 57.714 175 54 3 66 227 20 187 1.57E-61 194 CBX5_MOUSE reviewed Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) Cbx5 Hp1a Mus musculus (Mouse) 191 "negative regulation of transcription, DNA-templated [GO:0045892]" GO:0000118; GO:0000776; GO:0000784; GO:0000792; GO:0003682; GO:0005634; GO:0005720; GO:0005721; GO:0005730; GO:0010369; GO:0016605; GO:0017053; GO:0030674; GO:0035064; GO:0035097; GO:0042803; GO:0042826; GO:0045892; GO:0070491 0 0 0 PF00385;PF01393; Q6NVR1 CHOYP_ARPP19B.1.1 m.66654 sp ENSA_XENTR 60.377 53 20 1 55 106 31 83 1.57E-12 62.8 ENSA_XENTR reviewed Alpha-endosulfine ensa TTpA018o10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 125 cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067] GO:0000086; GO:0004864; GO:0005737; GO:0007067; GO:0008601; GO:0019212; GO:0051301; GO:0051721 0 0 0 PF04667; Q6NWH0 CHOYP_BRAFLDRAFT_87818.2.2 m.2755 sp CK068_DANRE 40.094 212 116 5 35 238 28 236 1.57E-43 150 CK068_DANRE reviewed UPF0696 protein C11orf68 homolog P5436 zgc:63470 Danio rerio (Zebrafish) (Brachydanio rerio) 249 0 0 0 0 0 PF08939; Q6UW60 CHOYP_FURIN.1.1 m.58067 sp PCSK4_HUMAN 36.226 530 307 13 17 538 119 625 1.57E-93 304 PCSK4_HUMAN reviewed Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4) PCSK4 PC4 UNQ2757/PRO6496 Homo sapiens (Human) 755 acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240] GO:0001669; GO:0002080; GO:0004252; GO:0005615; GO:0007339; GO:0007340; GO:0009566; GO:0016021; GO:0016485; GO:0022414; GO:0048240 0 0 0 PF01483;PF00082;PF16470; Q7Z429 CHOYP_BRAFLDRAFT_60532.1.1 m.60560 sp LFG1_HUMAN 40.24 333 174 10 4 318 45 370 1.57E-70 226 LFG1_HUMAN reviewed Protein lifeguard 1 (Glutamate [NMDA] receptor-associated protein 1) (NMDA receptor glutamate-binding subunit) (Putative MAPK-activating protein PM02) (Transmembrane BAX inhibitor motif-containing protein 3) GRINA LFG1 NMDARA1 TMBIM3 Homo sapiens (Human) 371 endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236] GO:0005783; GO:0005794; GO:0016021; GO:0032469; GO:1902236 0 0 0 0 Q7Z7K0 CHOYP_RFIP4.2.2 m.27419 sp COXM1_HUMAN 40.449 89 53 0 10 98 4 92 1.57E-16 73.9 COXM1_HUMAN reviewed COX assembly mitochondrial protein homolog (Cmc1p) CMC1 C3orf68 Homo sapiens (Human) 106 0 GO:0005739; GO:0046872 0 0 0 PF08583; Q80T91 CHOYP_MEG10.49.91 m.46468 sp MEG11_MOUSE 38.122 181 88 8 59 222 508 681 1.57E-24 106 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8IDX6 CHOYP_contig_045252 m.52579 sp RBP2A_PLAF7 39.412 170 86 6 198 362 2741 2898 1.57E-09 64.7 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8JIU7 CHOYP_NACA.9.9 m.65964 sp NACA_DANRE 72.358 123 26 3 1 115 1 123 1.57E-44 146 NACA_DANRE reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Danio rerio (Zebrafish) (Brachydanio rerio) 215 myofibril assembly [GO:0030239]; protein transport [GO:0015031] GO:0005634; GO:0005737; GO:0015031; GO:0030239 0 0 0 PF01849; Q8K285 CHOYP_LOC660969.1.1 m.44744 sp FCHO1_MOUSE 50 70 35 0 3 72 199 268 1.57E-16 78.6 FCHO1_MOUSE reviewed F-BAR domain only protein 1 Fcho1 Mus musculus (Mouse) 873 clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583] GO:0005886; GO:0005905; GO:0035612; GO:0048268; GO:0072583 0 0 0 PF00611;PF10291; Q8TB40 CHOYP_ABHD4.1.1 m.63088 sp ABHD4_HUMAN 55.522 335 141 5 41 373 14 342 1.57E-133 390 ABHD4_HUMAN reviewed Protein ABHD4 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 4) (Abhydrolase domain-containing protein 4) (Alpha/beta-hydrolase 4) (Lyso-N-acylphosphatidylethanolamine lipase) ABHD4 Homo sapiens (Human) 342 lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; phospholipid metabolic process [GO:0006644] GO:0005789; GO:0005811; GO:0006629; GO:0006644; GO:0016042; GO:0016787; GO:0019915; GO:0052689 0 0 0 PF00561; Q921Y2 CHOYP_LOC100371776.2.3 m.41075 sp IMP3_MOUSE 61.207 116 44 1 1 115 1 116 1.57E-48 156 IMP3_MOUSE reviewed U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) Imp3 Mus musculus (Mouse) 184 rRNA processing [GO:0006364] GO:0005634; GO:0005730; GO:0006364; GO:0030515; GO:0030519; GO:0032040; GO:0034457; GO:0044822 0 0 0 PF00163;PF01479; Q96AB6 CHOYP_BRAFLDRAFT_200206.1.1 m.35419 sp NTAN1_HUMAN 40.068 292 173 2 1 292 1 290 1.57E-77 243 NTAN1_HUMAN reviewed Protein N-terminal asparagine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein N-terminal asparagine amidase) (Protein NTN-amidase) NTAN1 Homo sapiens (Human) 310 adult locomotory behavior [GO:0008344]; memory [GO:0007613] GO:0005634; GO:0005737; GO:0007613; GO:0008344; GO:0008418 0 0 0 PF14736; Q96GP6 CHOYP_LOC579946.1.24 m.5233 sp SREC2_HUMAN 42.157 102 55 4 223 323 250 348 1.57E-15 81.6 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q99M80 CHOYP_PTPRT.31.45 m.53553 sp PTPRT_MOUSE 30.758 686 404 18 206 852 767 1420 1.57E-77 278 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9CQY2 CHOYP_ISCW_ISCW002750.3.3 m.26779 sp RAM_MOUSE 37.079 89 47 1 38 117 4 92 1.57E-09 55.5 RAM_MOUSE reviewed RNMT-activating mini protein (RAM) (Protein FAM103A1) Fam103a1 Mus musculus (Mouse) 119 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031] GO:0003723; GO:0005634; GO:0005845; GO:0006370; GO:0032259; GO:0036031; GO:0044822 0 0 0 PF15320; Q9CXE2 CHOYP_BCL7A.1.1 m.29528 sp BCL7A_MOUSE 78.846 52 11 0 1 52 1 52 1.57E-24 98.6 BCL7A_MOUSE reviewed B-cell CLL/lymphoma 7 protein family member A Bcl7a Mus musculus (Mouse) 210 0 0 0 0 0 PF04714; Q9HYV6 CHOYP_TVAG_075930.1.1 m.26971 sp Y3287_PSEAE 36.842 152 89 2 34 185 11 155 1.57E-19 86.3 Y3287_PSEAE reviewed Putative ankyrin repeat protein PA3287 PA3287 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 171 0 GO:0000151; GO:0004842; GO:0005737; GO:0031625 0 0 0 PF00023;PF12796; Q9IA76 CHOYP_RL31.1.2 m.21419 sp RL31_PAROL 68.595 121 38 0 1 121 1 121 1.57E-58 180 RL31_PAROL reviewed 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) 124 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00463; PF01198; Q9JLC8 CHOYP_BRAFLDRAFT_118535.2.8 m.18379 sp SACS_MOUSE 24.654 361 236 12 2 340 1881 2227 1.57E-21 100 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9NRG9 CHOYP_LOC100366577.2.2 m.40626 sp AAAS_HUMAN 60.606 132 52 0 1 132 134 265 1.57E-49 168 AAAS_HUMAN reviewed Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) 546 fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; learning [GO:0007612]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of nucleocytoplasmic transport [GO:0046822]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005813; GO:0006406; GO:0006409; GO:0006913; GO:0007077; GO:0007612; GO:0009566; GO:0010827; GO:0015031; GO:0016020; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031965; GO:0046822; GO:0075733; GO:1900034 0 0 0 PF00400; Q9U505 CHOYP_NEMVEDRAFT_V1G204676.1.2 m.30440 sp AT5G_MANSE 78.378 74 16 0 30 103 58 131 1.57E-33 115 AT5G_MANSE reviewed "ATP synthase lipid-binding protein, mitochondrial (ATPase protein 9) (ATPase subunit c)" 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 131 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0008289; GO:0015078; GO:0015986; GO:0015991; GO:0016021; GO:0031966; GO:0045263 0 0 0 PF00137; Q9UHB7 CHOYP_LOC100723342.1.1 m.58414 sp AFF4_HUMAN 31.56 282 165 8 930 1210 902 1156 1.57E-30 134 AFF4_HUMAN reviewed AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein) AFF4 AF5Q31 MCEF HSPC092 Homo sapiens (Human) 1163 spermatid development [GO:0007286]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003700; GO:0006366; GO:0007286; GO:0008023; GO:0035327 0 0 0 PF05110; Q9V9S7 CHOYP_LOC660562.1.1 m.17818 sp SYDE_DROME 47.11 346 166 4 527 855 799 1144 1.57E-100 348 SYDE_DROME reviewed Rho GTPase-activating protein 100F (RhoGAP-100F) (Synapse defective protein 1 homolog) (Protein syd-1 homolog) RhoGAP100F CG1976 Drosophila melanogaster (Fruit fly) 1866 activation of GTPase activity [GO:0090630]; axon extension involved in axon guidance [GO:0048846]; cytoskeletal matrix organization at active zone [GO:0048789]; maintenance of presynaptic active zone structure [GO:0048790]; R7 cell development [GO:0045467]; regulation of GTPase activity [GO:0043087]; Rho protein signal transduction [GO:0007266]; synaptic vesicle localization [GO:0097479] GO:0005096; GO:0005737; GO:0007266; GO:0043087; GO:0045467; GO:0048786; GO:0048789; GO:0048790; GO:0048846; GO:0090630; GO:0097479 0 0 0 PF00168;PF00595;PF00620; Q9VFB2 CHOYP_RT10.2.4 m.12766 sp RT10_DROME 45.89 146 72 2 57 197 25 168 1.57E-36 134 RT10_DROME reviewed "28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt)" mRpS10 CG4247 Drosophila melanogaster (Fruit fly) 173 sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005763; GO:0006412; GO:0019233 0 0 0 PF00338; S4R2P9 CHOYP_BRAFLDRAFT_78683.4.4 m.52590 sp NAC3_MOUSE 34.23 967 468 29 5 875 28 922 1.57E-141 446 NAC3_MOUSE reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Mus musculus (Mouse) 928 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; metal ion transport [GO:0030001]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005887; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0015368; GO:0016528; GO:0021537; GO:0030001; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; U3JAG9 CHOYP_LOC100374850.1.2 m.21316 sp CP131_DANRE 54.583 480 183 6 343 794 641 1113 1.57E-141 448 CP131_DANRE reviewed Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) cep131 azi1 Danio rerio (Zebrafish) (Brachydanio rerio) 1113 cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; negative regulation of intracellular protein transport [GO:0090317]; regulation of centrosome duplication [GO:0010824]; sensory perception of light stimulus [GO:0050953] GO:0000775; GO:0005929; GO:0010824; GO:0030154; GO:0032402; GO:0034451; GO:0035721; GO:0035735; GO:0050953; GO:0060271; GO:0060287; GO:0070121; GO:0090317 0 0 0 0 A1A5K6 CHOYP_LOC100875655.1.1 m.19309 sp TBC24_XENLA 35.24 542 278 12 226 716 30 549 1.58E-97 315 TBC24_XENLA reviewed TBC1 domain family member 24 tbc1d24 Xenopus laevis (African clawed frog) 562 0 GO:0005096 0 0 0 PF00566;PF07534; A5WW08 CHOYP_CHFR.1.1 m.7417 sp CHFR_DANRE 35.448 725 326 21 2 681 7 634 1.58E-135 415 CHFR_DANRE reviewed E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) chfr si:dkey-69h6.7 Danio rerio (Zebrafish) (Brachydanio rerio) 637 cell division [GO:0051301]; mitotic cell cycle checkpoint [GO:0007093]; mitotic nuclear division [GO:0007067]; modification-dependent protein catabolic process [GO:0019941]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000166; GO:0000209; GO:0004842; GO:0005634; GO:0006511; GO:0007067; GO:0007093; GO:0008270; GO:0016605; GO:0016874; GO:0019941; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00498; A8WHP9 CHOYP_SLIT2.2.3 m.38824 sp LRRC3_DANRE 32.828 198 114 6 16 202 21 210 1.58E-23 100 LRRC3_DANRE reviewed Leucine-rich repeat-containing protein 3 lrrc3 sc:d0333 si:dkey-253a1.3 Danio rerio (Zebrafish) (Brachydanio rerio) 266 0 GO:0016021 0 0 0 PF13855;PF01462; D9IQ16 CHOYP_NEMVEDRAFT_V1G211144.1.1 m.44601 sp GXN_ACRMI 25.758 198 107 9 2 177 146 325 1.58E-07 55.5 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 O01761 CHOYP_BM1_12515.7.7 m.55292 sp UNC89_CAEEL 22.993 461 298 20 3 437 4340 4769 1.58E-06 56.2 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O15990 CHOYP_KARG.2.11 m.2196 sp KARG_LIOJA 59.791 383 118 3 29 410 2 349 1.58E-159 456 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O15990 CHOYP_KARG.9.11 m.50527 sp KARG_LIOJA 70.073 137 41 0 32 168 46 182 1.58E-67 211 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O70277 CHOYP_BRAFLDRAFT_87336.9.9 m.52698 sp TRIM3_RAT 25.41 122 86 3 29 145 622 743 1.58E-06 50.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88799 CHOYP_contig_047077 m.55393 sp ZAN_MOUSE 26.134 463 266 15 11 400 660 1119 1.58E-10 67 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; P09760 CHOYP_LOC100179439.1.1 m.6857 sp FER_RAT 27.778 234 148 9 435 667 609 822 1.58E-14 82.8 FER_RAT reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) (Proto-oncogene c-Fer) (Tyrosine-protein kinase FLK) (p94-Fer) Fer Fert2 Flk Rattus norvegicus (Rat) 823 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cellular response to insulin stimulus [GO:0032869]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; epidermal growth factor receptor signaling pathway [GO:0007173]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of cell proliferation [GO:0042127]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0000226; GO:0001932; GO:0003779; GO:0004715; GO:0005102; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005856; GO:0005938; GO:0006935; GO:0007155; GO:0007173; GO:0008092; GO:0008283; GO:0008289; GO:0010591; GO:0017137; GO:0018108; GO:0019221; GO:0019901; GO:0030054; GO:0030154; GO:0030335; GO:0030838; GO:0031234; GO:0031532; GO:0032496; GO:0032869; GO:0033007; GO:0034446; GO:0034614; GO:0035426; GO:0036119; GO:0038028; GO:0038083; GO:0038095; GO:0038109; GO:0042058; GO:0042127; GO:0042995; GO:0043304; GO:0044331; GO:0045087; GO:0045295; GO:0045296; GO:0048008; GO:0050839; GO:0050904; GO:0051092 0 0 0 PF00611;PF07714;PF00017; P0C870 CHOYP_LOC100888222.2.3 m.36950 sp JMJD7_HUMAN 26.861 309 166 11 56 348 36 300 1.58E-31 124 JMJD7_HUMAN reviewed JmjC domain-containing protein 7 (Jumonji domain-containing protein 7) JMJD7 Homo sapiens (Human) 316 0 0 0 0 0 0 P10041 CHOYP_SVEP1.6.8 m.38436 sp DL_DROME 50.394 127 59 1 344 470 446 568 1.58E-32 137 DL_DROME reviewed Neurogenic locus protein delta Dl CG3619 Drosophila melanogaster (Fruit fly) 833 "actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; asymmetric cell division [GO:0008356]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye retinal cell programmed cell death [GO:0046667]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; ectoderm development [GO:0007398]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; germ-line stem cell population maintenance [GO:0030718]; glial cell migration [GO:0008347]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; R3/R4 cell fate commitment [GO:0007464]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of R8 cell spacing in compound eye [GO:0045468]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]; stem cell differentiation [GO:0048863]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]" GO:0001708; GO:0001736; GO:0005102; GO:0005112; GO:0005509; GO:0005768; GO:0005886; GO:0005912; GO:0007015; GO:0007155; GO:0007219; GO:0007298; GO:0007314; GO:0007398; GO:0007399; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007451; GO:0007460; GO:0007464; GO:0007474; GO:0007475; GO:0007476; GO:0007480; GO:0007498; GO:0008284; GO:0008347; GO:0008356; GO:0008407; GO:0008586; GO:0009986; GO:0016021; GO:0016318; GO:0016330; GO:0019233; GO:0030139; GO:0030431; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0031410; GO:0035003; GO:0035155; GO:0035157; GO:0036011; GO:0042067; GO:0042676; GO:0045465; GO:0045468; GO:0045931; GO:0046331; GO:0046667; GO:0048190; GO:0048477; GO:0048749; GO:0048800; GO:0048863; GO:0050768 0 0 0 PF01414;PF00008;PF12661;PF07657; P37397 CHOYP_SMP_078690.5.5 m.64878 sp CNN3_RAT 36.396 283 160 8 9 286 11 278 1.58E-40 150 CNN3_RAT reviewed "Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform)" Cnn3 Rattus norvegicus (Rat) 330 actomyosin structure organization [GO:0031032]; epithelial cell differentiation [GO:0030855]; negative regulation of ATPase activity [GO:0032780] GO:0005737; GO:0005874; GO:0005884; GO:0005925; GO:0008017; GO:0014069; GO:0030425; GO:0030674; GO:0030855; GO:0031032; GO:0032780; GO:0043025; GO:0043197 0 0 0 PF00402;PF00307; P48605 CHOYP_TCPG.1.1 m.30926 sp TCPG_DROME 74.525 263 67 0 1 263 1 263 1.58E-133 421 TCPG_DROME reviewed T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) Cctgamma CCT-3 Cctg CG8977 Drosophila melanogaster (Fruit fly) 544 "mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; protein folding [GO:0006457]; terminal branching, open tracheal system [GO:0007430]; trachea morphogenesis [GO:0060439]" GO:0005524; GO:0005832; GO:0005875; GO:0006457; GO:0007052; GO:0007430; GO:0042623; GO:0060439; GO:0090307 0 0 cd03337; PF00118; P49013 CHOYP_TRIADDRAFT_26618.2.3 m.61227 sp FBP3_STRPU 38.71 372 197 6 222 565 72 440 1.58E-73 248 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P52730 CHOYP_EN1-A.1.1 m.11558 sp HME2B_XENLA 72 125 34 1 86 210 137 260 1.58E-57 185 HME2B_XENLA reviewed Homeobox protein engrailed-2-B (En-2B) (Homeobox protein en-2-B) (En2 MABEN) en2-b en2b Xenopus laevis (African clawed frog) 265 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF10525;PF00046; P55113 CHOYP_LOC100491886.1.1 m.26703 sp NAS7_CAEEL 36.275 204 117 8 152 350 84 279 1.58E-31 130 NAS7_CAEEL reviewed Zinc metalloproteinase nas-7 (EC 3.4.24.21) (Nematode astacin 7) nas-7 C07D10.4 Caenorhabditis elegans 382 pharyngeal pumping [GO:0043050]; pharynx development [GO:0060465] GO:0004222; GO:0005576; GO:0008270; GO:0043050; GO:0060465 0 0 0 PF01400;PF01549; P67985 CHOYP_RL22.3.4 m.24854 sp RL22_PIG 75.701 107 25 1 22 127 9 115 1.58E-43 145 RL22_PIG reviewed 60S ribosomal protein L22 (Heparin-binding protein HBp15) RPL22 Sus scrofa (Pig) 128 alpha-beta T cell differentiation [GO:0046632]; cytoplasmic translation [GO:0002181] GO:0002181; GO:0003723; GO:0003735; GO:0008201; GO:0022625; GO:0046632 0 0 0 PF01776; P70365 CHOYP_ISCW_ISCW017872.1.2 m.19456 sp NCOA1_MOUSE 50.746 201 92 3 29 225 32 229 1.58E-59 205 NCOA1_MOUSE reviewed Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Nuclear receptor coactivator protein 1) (mNRC-1) (Steroid receptor coactivator 1) (SRC-1) Ncoa1 Src1 Mus musculus (Mouse) 1447 "cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; histone H4 acetylation [GO:0043967]; hypothalamus development [GO:0021854]; labyrinthine layer morphogenesis [GO:0060713]; lactation [GO:0007595]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of female receptivity [GO:0045925]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:0000435]; regulation of cellular response to drug [GO:2001038]; regulation of RNA biosynthetic process [GO:2001141]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; transcription, DNA-templated [GO:0006351]" GO:0000435; GO:0000790; GO:0001012; GO:0002155; GO:0003677; GO:0003682; GO:0003713; GO:0004402; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0007595; GO:0008134; GO:0008584; GO:0016922; GO:0019899; GO:0021549; GO:0021766; GO:0021854; GO:0021987; GO:0030374; GO:0032355; GO:0032526; GO:0032570; GO:0032870; GO:0035257; GO:0043005; GO:0043065; GO:0043967; GO:0044849; GO:0045666; GO:0045893; GO:0045925; GO:0045944; GO:0047485; GO:0060179; GO:0060713; GO:1904017; GO:2001038; GO:2001141 0 0 0 PF07469;PF00010;PF08815;PF00989;PF08832; P83425 CHOYP_HIP.3.3 m.65261 sp HIP_MYTED 31.008 129 86 2 23 149 85 212 1.58E-11 62.8 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q04832 CHOYP_RN45S.2.5 m.14111 sp HEXP_LEIMA 35.165 182 77 4 62 202 3 184 1.58E-24 100 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q06546 CHOYP_GABPA.1.1 m.15077 sp GABPA_HUMAN 50.474 422 167 9 109 503 24 430 1.58E-136 406 GABPA_HUMAN reviewed GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60) GABPA E4TF1A Homo sapiens (Human) 454 cell differentiation [GO:0030154]; in utero embryonic development [GO:0001701]; mitochondrion organization [GO:0007005]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0000790; GO:0000978; GO:0001077; GO:0001228; GO:0001701; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0006366; GO:0007005; GO:0030154; GO:0044212; GO:0045653; GO:0045944; GO:0046982 0 0 0 PF00178;PF11620;PF02198; Q12872 CHOYP_LOC100716402.1.1 m.36363 sp SFSWA_HUMAN 35.414 833 377 24 22 712 34 847 1.58E-103 345 SFSWA_HUMAN reviewed "Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)" SFSWAP SFRS8 SWAP Homo sapiens (Human) 951 "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA 5'-splice site recognition [GO:0000395]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000380; GO:0000395; GO:0003723; GO:0005634; GO:0006351; GO:0006355; GO:0048025 0 0 0 PF09750;PF01805; Q12955 CHOYP_LOC581927.7.27 m.20627 sp ANK3_HUMAN 27.976 840 498 32 23 830 48 812 1.58E-50 197 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q14624 CHOYP_LOC662543.1.1 m.39811 sp ITIH4_HUMAN 34.466 824 424 23 35 798 34 801 1.58E-121 394 ITIH4_HUMAN reviewed Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) 930 acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; platelet degranulation [GO:0002576]; response to cytokine [GO:0034097] GO:0002576; GO:0004866; GO:0004867; GO:0005576; GO:0005886; GO:0006953; GO:0030212; GO:0031089; GO:0034097; GO:0070062; GO:0072562 0 0 0 PF06668;PF08487;PF00092; Q2EMV9 CHOYP_PARP14.15.22 m.52654 sp PAR14_MOUSE 26.352 1017 656 31 272 1246 460 1425 1.58E-74 276 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q3T0B7 CHOYP_LOC100020225.1.1 m.30019 sp RS27L_BOVIN 87.805 82 10 0 38 119 3 84 1.58E-45 145 RS27L_BOVIN reviewed 40S ribosomal protein S27-like RPS27L Bos taurus (Bovine) 84 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627; GO:0046872 0 0 0 PF01667; Q4V8V2 CHOYP_NUD17.1.1 m.13156 sp NUD17_DANRE 43.189 301 153 7 34 331 6 291 1.58E-68 219 NUD17_DANRE reviewed Nucleoside diphosphate-linked moiety X motif 17 (Nudix motif 17) (EC 3.6.1.-) nudt17 zgc:114128 Danio rerio (Zebrafish) (Brachydanio rerio) 300 0 GO:0016787; GO:0046872 0 0 cd04694; PF00293; Q54KA7 CHOYP_AFUA_1G01020.41.50 m.61396 sp SECG_DICDI 39.216 204 123 1 1 203 291 494 1.58E-33 129 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q562E7 CHOYP_LOC100748268.1.1 m.47935 sp WDR81_HUMAN 30.705 1319 753 36 584 1833 715 1941 1.58E-158 538 WDR81_HUMAN reviewed WD repeat-containing protein 81 WDR81 Homo sapiens (Human) 1941 establishment of mitotic spindle orientation [GO:0000132]; germ cell development [GO:0007281]; microtubule organizing center organization [GO:0031023]; negative regulation of phosphatase activity [GO:0010923]; neurogenesis [GO:0022008]; nuclear migration [GO:0007097]; regulation of microtubule motor activity [GO:2000574]; retrograde axonal transport [GO:0008090]; vesicle transport along microtubule [GO:0047496] GO:0000132; GO:0000776; GO:0005739; GO:0005813; GO:0005874; GO:0005875; GO:0005938; GO:0007097; GO:0007281; GO:0008017; GO:0008090; GO:0010923; GO:0022008; GO:0031023; GO:0045502; GO:0047496; GO:1904115; GO:2000574 0 0 cd06071; PF02138;PF00400; Q5FVK8 CHOYP_BRAFLDRAFT_124346.1.2 m.18997 sp AL14E_RAT 50.962 104 45 2 2 100 151 253 1.58E-29 109 AL14E_RAT reviewed ARL14 effector protein (ARF7 effector protein) Arl14ep Arf7ep Rattus norvegicus (Rat) 276 0 GO:0005737 0 0 0 PF14949; Q5U2Q4 CHOYP_PARP16.1.1 m.1294 sp PAR16_RAT 43.366 309 163 4 14 313 10 315 1.58E-85 263 PAR16_RAT reviewed Mono [ADP-ribose] polymerase PARP16 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16) Parp16 Artd15 Rattus norvegicus (Rat) 322 response to unfolded protein [GO:0006986] GO:0003950; GO:0005789; GO:0006986; GO:0016021 0 0 0 PF00644; Q5ZIJ9 CHOYP_MIB2.3.6 m.35733 sp MIB2_CHICK 35.426 892 515 17 1 851 9 880 1.58E-161 498 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q60787 CHOYP_LCP2.7.14 m.20075 sp LCP2_MOUSE 30.568 229 133 6 383 595 305 523 1.58E-19 95.9 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q61830 CHOYP_LOC100378295.3.4 m.30298 sp MRC1_MOUSE 29.008 131 75 6 193 309 361 487 1.58E-06 53.5 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q6DIB5 CHOYP_MEGF6.1.59 m.1169 sp MEG10_MOUSE 39.744 234 123 11 179 407 348 568 1.58E-30 127 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6IR80 CHOYP_BRAFLDRAFT_114977.2.2 m.36517 sp CL066_XENLA 34.783 184 112 2 15 194 262 441 1.58E-33 127 CL066_XENLA reviewed UPF0536 protein C12orf66 homolog 0 Xenopus laevis (African clawed frog) 442 0 0 0 0 0 PF09404; Q6P9T8 CHOYP_BRAFLDRAFT_60807.2.2 m.50657 sp TBB4B_RAT 94.33 194 10 1 1 194 1 193 1.58E-122 357 TBB4B_RAT reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Rattus norvegicus (Rat) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q6PFY8 CHOYP_LOC100374741.15.83 m.20489 sp TRI45_MOUSE 23.944 213 143 7 51 250 191 397 1.58E-06 54.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6V0K7 CHOYP_LOC100536772.2.2 m.61474 sp OIT3_RAT 31.522 184 115 5 6 182 5 184 1.58E-12 72.4 OIT3_RAT reviewed Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) 546 0 GO:0005509; GO:0005635 0 0 0 PF00100; Q70FJ1 CHOYP_LOC100186299.2.6 m.7827 sp AKAP9_MOUSE 33.619 467 283 8 1010 1475 1678 2118 1.58E-43 180 AKAP9_MOUSE reviewed A-kinase anchor protein 9 (AKAP-9) (Protein kinase A-anchoring protein 9) (PRKA9) Akap9 Kiaa0803 Mus musculus (Mouse) 3797 microtubule nucleation [GO:0007020]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] GO:0000242; GO:0005737; GO:0005794; GO:0005795; GO:0005813; GO:0007020; GO:0007165; GO:0007283; GO:0036064; GO:0060009 0 0 0 PF10495; Q7TN88 CHOYP_REJ6.1.4 m.31267 sp PK1L2_MOUSE 21.935 620 440 13 235 838 1809 2400 1.58E-39 165 PK1L2_MOUSE reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) 2461 detection of mechanical stimulus [GO:0050982] GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q7TP17 CHOYP_BRAFLDRAFT_114843.2.2 m.57232 sp U2AF4_RAT 80.311 193 31 2 119 310 10 196 1.58E-112 329 U2AF4_RAT reviewed Splicing factor U2AF 26 kDa subunit (Liver regeneration-related protein LRRG157/LRRG158) (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) U2af1l4 Cb2-806 Cb2-807 Rattus norvegicus (Rat) 220 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005681; GO:0005737; GO:0016607; GO:0046872; GO:0089701 0 0 0 PF00076;PF00642; Q7Z0T3 CHOYP_TRIADDRAFT_32712.3.4 m.44104 sp TEMPT_APLCA 46.067 89 47 1 2 89 7 95 1.58E-15 71.2 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q8CGC6 CHOYP_LOC100183682.1.1 m.61630 sp RBM28_MOUSE 37.178 737 352 20 189 849 48 749 1.58E-113 366 RBM28_MOUSE reviewed RNA-binding protein 28 (RNA-binding motif protein 28) Rbm28 Mus musculus (Mouse) 750 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0005681; GO:0005730; GO:0006397; GO:0008380; GO:0044822 0 0 0 PF00076; Q8IYB1 CHOYP_LOC100377311.4.14 m.32472 sp M21D2_HUMAN 25.714 175 109 6 34 201 225 385 1.58E-07 57.8 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8IYB1 CHOYP_LOC100377311.5.14 m.32629 sp M21D2_HUMAN 24.39 205 124 7 142 337 244 426 1.58E-07 56.6 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8K0U4 CHOYP_LOC100374651.4.4 m.60476 sp HS12A_MOUSE 31.955 629 356 13 10 577 56 673 1.58E-96 311 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8VI56 CHOYP_LOC578656.3.15 m.20715 sp LRP4_MOUSE 26.838 585 397 18 1 568 778 1348 1.58E-60 226 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q90670 CHOYP_AVR2B.1.1 m.10221 sp AVR2B_CHICK 50 488 220 11 28 506 24 496 1.58E-159 466 AVR2B_CHICK reviewed Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) ACVR2B Gallus gallus (Chicken) 512 activin receptor signaling pathway [GO:0032924]; axis specification [GO:0009798]; cell proliferation [GO:0008283]; cranial ganglion development [GO:0061550]; mesodermal cell differentiation [GO:0048333]; negative regulation of transforming growth factor beta activation [GO:1901389]; positive regulation of neuron apoptotic process [GO:0043525] GO:0004675; GO:0004702; GO:0005524; GO:0008283; GO:0009798; GO:0016021; GO:0032924; GO:0043525; GO:0045178; GO:0046872; GO:0048185; GO:0048333; GO:0061550; GO:1901389 0 0 0 PF01064;PF00069; Q91YR1 CHOYP_TWF1.1.1 m.62154 sp TWF1_MOUSE 57.185 341 143 3 1 339 1 340 1.58E-143 412 TWF1_MOUSE reviewed Twinfilin-1 (Protein A6) Twf1 Ptk9 Mus musculus (Mouse) 350 barbed-end actin filament capping [GO:0051016]; negative regulation of actin filament polymerization [GO:0030837]; regulation of actin phosphorylation [GO:0043538]; sequestering of actin monomers [GO:0042989] GO:0003785; GO:0004713; GO:0005524; GO:0005546; GO:0005737; GO:0005911; GO:0005925; GO:0015629; GO:0030016; GO:0030175; GO:0030837; GO:0032403; GO:0042989; GO:0043538; GO:0048471; GO:0051016 0 0 0 PF00241; Q96MM6 CHOYP_LOC100488894.3.5 m.33699 sp HS12B_HUMAN 30.854 632 345 19 861 1419 61 673 1.58E-79 281 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99996 CHOYP_LOC100368547.35.40 m.59544 sp AKAP9_HUMAN 52.632 57 24 2 65 119 3577 3632 1.58E-07 52.4 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9BWH6 CHOYP_RPAP1.3.4 m.49643 sp RPAP1_HUMAN 43 200 110 2 70 265 1167 1366 1.58E-44 164 RPAP1_HUMAN reviewed RNA polymerase II-associated protein 1 RPAP1 KIAA1403 Homo sapiens (Human) 1393 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0006366 0 0 0 PF08620;PF08621; Q9BYW2 CHOYP_SETD2.1.1 m.25547 sp SETD2_HUMAN 37.867 750 383 15 3272 3986 1473 2174 1.58E-126 453 SETD2_HUMAN reviewed Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.43) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (SET domain-containing protein 2) (hSET2) (p231HBP) SETD2 HIF1 HYPB KIAA1732 KMT3A SET2 HSPC069 Homo sapiens (Human) 2564 "angiogenesis [GO:0001525]; cell migration involved in vasculogenesis [GO:0035441]; coronary vasculature morphogenesis [GO:0060977]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic placenta morphogenesis [GO:0060669]; forebrain development [GO:0030900]; histone H3-K36 dimethylation [GO:0097676]; histone H3-K36 trimethylation [GO:0097198]; mesoderm morphogenesis [GO:0048332]; mismatch repair [GO:0006298]; morphogenesis of a branching structure [GO:0001763]; neural tube closure [GO:0001843]; nucleosome organization [GO:0034728]; pericardium development [GO:0060039]; regulation of mRNA export from nucleus [GO:0010793]; regulation of transcription, DNA-templated [GO:0006355]; stem cell development [GO:0048864]; transcription elongation from RNA polymerase II promoter [GO:0006368]" GO:0001525; GO:0001763; GO:0001843; GO:0005654; GO:0005694; GO:0006298; GO:0006355; GO:0006368; GO:0010793; GO:0018024; GO:0030900; GO:0034728; GO:0035441; GO:0046975; GO:0048332; GO:0048701; GO:0048864; GO:0060039; GO:0060669; GO:0060977; GO:0097198; GO:0097676 0 0 0 PF00856;PF08236;PF00397; Q9BZE4 CHOYP_CPIPJ_CPIJ004960.1.1 m.19350 sp NOG1_HUMAN 84.305 223 35 0 1 223 1 223 1.58E-144 421 NOG1_HUMAN reviewed Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB) GTPBP4 CRFG NOG1 Homo sapiens (Human) 634 negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of collagen binding [GO:0033342]; negative regulation of DNA replication [GO:0008156]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; protein stabilization [GO:0050821]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; ribosome biogenesis [GO:0042254] GO:0000079; GO:0001649; GO:0003924; GO:0005525; GO:0005634; GO:0005730; GO:0005737; GO:0005794; GO:0008156; GO:0008285; GO:0016020; GO:0022408; GO:0030336; GO:0031397; GO:0031965; GO:0033342; GO:0042254; GO:0044822; GO:0048471; GO:0050821 0 0 0 PF06858;PF08155; Q9D3N2 CHOYP_LOC100366575.1.1 m.29959 sp EFCB1_MOUSE 53.555 211 89 3 4 207 1 209 1.58E-73 224 EFCB1_MOUSE reviewed EF-hand calcium-binding domain-containing protein 1 Efcab1 Mus musculus (Mouse) 212 0 GO:0005509 0 0 0 PF00036;PF13499; Q9NZN8 CHOYP_CNOT2.1.2 m.47530 sp CNOT2_HUMAN 47.732 507 204 16 95 561 53 538 1.58E-130 394 CNOT2_HUMAN reviewed CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2) CNOT2 CDC36 NOT2 HSPC131 MSTP046 Homo sapiens (Human) 540 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; gene silencing by RNA [GO:0031047]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; transcription, DNA-templated [GO:0006351]; trophectodermal cell differentiation [GO:0001829]" GO:0000122; GO:0000288; GO:0000289; GO:0000932; GO:0001104; GO:0001226; GO:0001829; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006357; GO:0006977; GO:0010606; GO:0016020; GO:0017148; GO:0030014; GO:0030015; GO:0031047; GO:0033147; GO:0090503; GO:2000036 0 0 0 PF04153; Q9P0M2 CHOYP_BRAFLDRAFT_131751.1.1 m.1786 sp AKA7G_HUMAN 31.606 193 125 5 132 320 85 274 1.58E-19 91.3 AKA7G_HUMAN reviewed A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) 348 0 GO:0000166; GO:0005634; GO:0005829; GO:0051018 0 0 0 PF10469;PF10470; Q9UIF8 CHOYP_PHUM_PHUM235290.1.1 m.22978 sp BAZ2B_HUMAN 32.353 136 83 3 1 127 768 903 1.58E-17 81.6 BAZ2B_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00439;PF02791;PF01429;PF00628;PF15613; Q9UPY6 CHOYP_LOC100883571.1.1 m.42323 sp WASF3_HUMAN 46.262 214 114 1 1 213 1 214 1.58E-53 192 WASF3_HUMAN reviewed Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3) WASF3 KIAA0900 SCAR3 WAVE3 Homo sapiens (Human) 502 actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; oligodendrocyte development [GO:0014003]; positive regulation of myelination [GO:0031643]; protein complex assembly [GO:0006461]; regulation of cell shape [GO:0008360] GO:0005737; GO:0005856; GO:0006461; GO:0007010; GO:0008360; GO:0014003; GO:0030027; GO:0030032; GO:0030041; GO:0031643; GO:0070062 0 0 0 PF02205; Q9VC57 CHOYP_ATLAS.1.1 m.35960 sp ATLAS_DROME 60.294 136 52 2 5 138 32 167 1.58E-49 169 ATLAS_DROME reviewed Atlastin (EC 3.6.5.-) atl CG6668 Drosophila melanogaster (Fruit fly) 541 endoplasmic reticulum membrane fusion [GO:0016320]; endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; microtubule depolymerization [GO:0007019]; muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; protein homooligomerization [GO:0051260]; regulation of microtubule depolymerization [GO:0031114]; regulation of synaptic growth at neuromuscular junction [GO:0008582]; synaptic growth at neuromuscular junction [GO:0051124] GO:0000139; GO:0003924; GO:0005525; GO:0005737; GO:0005783; GO:0005794; GO:0007019; GO:0007029; GO:0007030; GO:0007517; GO:0007528; GO:0008582; GO:0012505; GO:0016020; GO:0016021; GO:0016320; GO:0031114; GO:0031227; GO:0032561; GO:0042802; GO:0042803; GO:0051124; GO:0051260; GO:0061025 0 0 0 PF02263; Q9VCA2 CHOYP_BRAFLDRAFT_257702.1.1 m.27449 sp ORCT_DROME 36.92 539 307 10 2 527 21 539 1.58E-99 314 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9VWK6 CHOYP_BRAFLDRAFT_69729.1.1 m.684 sp PGP2L_DROME 42.038 157 84 2 1 153 149 302 1.58E-28 112 PGP2L_DROME reviewed Post-GPI attachment to proteins factor 2-like CG7990 Drosophila melanogaster (Fruit fly) 325 0 GO:0016021 0 0 0 PF10277; A4IF63 CHOYP_BRAFLDRAFT_206799.3.23 m.3765 sp TRIM2_BOVIN 23.111 225 164 3 4 224 525 744 1.59E-08 57.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H3BNL1 CHOYP_LOC100371168.1.1 m.54022 sp CC084_HUMAN 42.609 115 64 2 10 124 3 115 1.59E-22 95.9 CC084_HUMAN reviewed Uncharacterized protein C3orf84 C3orf84 Homo sapiens (Human) 204 0 0 0 0 0 PF15115; O08785 CHOYP_LOC100552330.1.1 m.8158 sp CLOCK_MOUSE 57.609 368 139 5 45 400 30 392 1.59E-138 429 CLOCK_MOUSE reviewed Circadian locomoter output cycles protein kaput (mCLOCK) (EC 2.3.1.48) Clock Mus musculus (Mouse) 855 "cellular response to ionizing radiation [GO:0071479]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA damage checkpoint [GO:0000077]; entrainment of circadian clock [GO:0009649]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of hair cycle [GO:0042634]; regulation of insulin secretion [GO:0050796]; regulation of transcription, DNA-templated [GO:0006355]; regulation of type B pancreatic cell development [GO:2000074]; response to light stimulus [GO:0009416]; response to redox state [GO:0051775]; spermatogenesis [GO:0007283]" GO:0000077; GO:0000978; GO:0000982; GO:0001046; GO:0001047; GO:0001077; GO:0001190; GO:0003677; GO:0003700; GO:0004402; GO:0005634; GO:0005654; GO:0005667; GO:0005694; GO:0005737; GO:0005829; GO:0006355; GO:0007283; GO:0007623; GO:0008134; GO:0009416; GO:0009649; GO:0031490; GO:0032922; GO:0033391; GO:0042634; GO:0043161; GO:0043231; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0050729; GO:0050796; GO:0051092; GO:0051775; GO:0070888; GO:0071479; GO:2000074; GO:2000323 0 0 0 PF00010;PF00989; O14522 CHOYP_MEG11.22.25 m.59241 sp PTPRT_HUMAN 30.685 365 210 9 408 732 688 1049 1.59E-37 154 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O42123 CHOYP_FKBP1AA.1.1 m.26101 sp FKB1A_XENLA 65.741 108 37 0 15 122 1 108 1.59E-49 156 FKB1A_XENLA reviewed Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) fkbp1a Xenopus laevis (African clawed frog) 108 amyloid fibril formation [GO:1990000]; cytokine-mediated signaling pathway [GO:0019221]; extracellular fibril organization [GO:0043206]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; muscle contraction [GO:0006936]; negative regulation of protein phosphatase type 2B activity [GO:0032513]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; release of sequestered calcium ion into cytosol [GO:0051209]; response to caffeine [GO:0031000]; SMAD protein complex assembly [GO:0007183]; T cell proliferation [GO:0042098]; ventricular cardiac muscle tissue morphogenesis [GO:0055010] GO:0000413; GO:0001933; GO:0003007; GO:0003755; GO:0004871; GO:0005528; GO:0005737; GO:0005829; GO:0006457; GO:0006936; GO:0007183; GO:0008144; GO:0014802; GO:0016020; GO:0019221; GO:0019855; GO:0030018; GO:0031000; GO:0031012; GO:0031398; GO:0032092; GO:0032513; GO:0032880; GO:0032925; GO:0033017; GO:0042098; GO:0042803; GO:0043123; GO:0043206; GO:0044325; GO:0046332; GO:0048185; GO:0050776; GO:0051209; GO:0051280; GO:0055010; GO:0060314; GO:0060315; GO:0060347; GO:0070062; GO:1902991; GO:1990000 0 0 0 PF00254; O73791 CHOYP_LOC100371242.6.6 m.65598 sp TIE2_DANRE 35.2 125 73 4 6 126 215 335 1.59E-17 80.5 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O75342 CHOYP_BRAFLDRAFT_118620.2.3 m.52438 sp LX12B_HUMAN 28.661 478 287 15 142 596 255 701 1.59E-45 174 LX12B_HUMAN reviewed "Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)" ALOX12B Homo sapiens (Human) 701 arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipoxygenase pathway [GO:0019372]; oxidation-reduction process [GO:0055114]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665] GO:0004052; GO:0005506; GO:0005829; GO:0006497; GO:0006665; GO:0010628; GO:0016702; GO:0019369; GO:0019372; GO:0043410; GO:0043651; GO:0046513; GO:0051122; GO:0055114; GO:0061436; GO:0070257; GO:1990136 PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:21558561}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:21558561}. 0 0 PF00305;PF01477; O88281 CHOYP_BRAFLDRAFT_224574.5.18 m.24298 sp MEGF6_RAT 37.743 257 147 9 193 449 736 979 1.59E-28 122 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O93477 CHOYP_SAHH3.2.2 m.51222 sp SAHHB_XENLA 77.13 223 51 0 1 223 211 433 1.59E-125 364 SAHHB_XENLA reviewed Adenosylhomocysteinase B (AdoHcyase B) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase B) ahcy-b ahcy2 sahh Xenopus laevis (African clawed frog) 433 one-carbon metabolic process [GO:0006730] GO:0004013; GO:0006730 PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. 0 cd00401; PF05221;PF00670; P04634 CHOYP_RS27L.3.4 m.33065 sp LIPG_RAT 52.294 109 52 0 1 109 287 395 1.59E-34 125 LIPG_RAT reviewed Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) (Lingual lipase) Lipf Rattus norvegicus (Rat) 395 digestion [GO:0007586]; lipid catabolic process [GO:0016042]; malate metabolic process [GO:0006108] GO:0004806; GO:0005576; GO:0005739; GO:0006108; GO:0007586; GO:0016042; GO:0016298; GO:0016615 0 0 0 PF00561; P15252 CHOYP_REF.2.2 m.25065 sp REF_HEVBR 54.135 133 58 1 45 174 5 137 1.59E-41 139 REF_HEVBR reviewed Rubber elongation factor protein (HbREF) (allergen Hev b 1) 0 Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis) 138 0 GO:0005737 0 0 0 PF05755; P18117 CHOYP_LOC100313752.1.1 m.7638 sp THBA_XENLA 49.189 370 171 6 117 473 8 373 1.59E-114 345 THBA_XENLA reviewed Thyroid hormone receptor beta-A (TRbetaA) (xTR) (Nuclear receptor subfamily 1 group A member 2-A) thrb-a nr1a2-a thrb1 Xenopus laevis (African clawed frog) 373 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003707; GO:0004887; GO:0005634; GO:0006351; GO:0008270; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0070324 0 0 0 PF00104;PF00105; P21941 CHOYP_TTN.7.9 m.46088 sp MATN1_HUMAN 34.634 205 118 5 97 296 268 461 1.59E-27 121 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P27473 CHOYP_SI_CH211-197G15.10.5.7 m.38867 sp IFI44_PANTR 31.057 454 262 13 14 453 7 423 1.59E-53 189 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P35285 CHOYP_LOC585164.1.1 m.51658 sp RB22A_MOUSE 57.143 196 82 1 1 196 1 194 1.59E-77 233 RB22A_MOUSE reviewed Ras-related protein Rab-22A (Rab-22) (Rab-14) Rab22a Rab22 Mus musculus (Mouse) 194 endocytosis [GO:0006897]; endosome organization [GO:0007032]; protein transport [GO:0015031]; regulation of vesicle size [GO:0097494]; small GTPase mediated signal transduction [GO:0007264] GO:0001726; GO:0003924; GO:0005525; GO:0005769; GO:0005770; GO:0005886; GO:0006897; GO:0007032; GO:0007264; GO:0010008; GO:0015031; GO:0015629; GO:0019003; GO:0030670; GO:0045335; GO:0070062; GO:0097494 0 0 0 PF00071; P42577 CHOYP_LOC100533455.9.9 m.66519 sp FRIS_LYMST 86.25 80 11 0 28 107 33 112 1.59E-46 151 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P42669 CHOYP_ISCW_ISCW005651.1.1 m.49000 sp PURA_MOUSE 55 220 90 4 18 230 58 275 1.59E-80 247 PURA_MOUSE reviewed Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha) Pura Mus musculus (Mouse) 321 "apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; DNA unwinding involved in DNA replication [GO:0006268]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; positive regulation of cell proliferation [GO:0008284]; transcription, DNA-templated [GO:0006351]" GO:0000900; GO:0003677; GO:0003690; GO:0003691; GO:0003697; GO:0003700; GO:0005634; GO:0005662; GO:0005737; GO:0006268; GO:0006351; GO:0006915; GO:0007093; GO:0007399; GO:0008134; GO:0008283; GO:0008284; GO:0030154; GO:0030425; GO:0032422; GO:0043025; GO:0044822; GO:0045892; GO:0046332 0 0 0 PF04845; P62154 CHOYP_LOC100533341.1.1 m.1847 sp CALM_LOCMI 100 149 0 0 1 149 1 149 1.59E-104 297 CALM_LOCMI reviewed Calmodulin (CaM) 0 Locusta migratoria (Migratory locust) 149 0 GO:0005509 0 0 0 PF13499; P62864 CHOYP_MGC89853.7.7 m.58813 sp RS30_RAT 86.441 59 8 0 73 131 1 59 1.59E-21 84.3 RS30_RAT reviewed 40S ribosomal protein S30 Fau Rattus norvegicus (Rat) 59 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF04758; P86221 CHOYP_TBB4B.4.7 m.39104 sp TBB4B_MESAU 97.436 156 4 0 1 156 1 156 1.59E-112 323 TBB4B_MESAU reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) 290 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091; P86854 CHOYP_LOC100081235.1.2 m.8496 sp PLCL_MYTGA 34.286 140 87 5 102 238 19 156 1.59E-21 90.5 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q05B56 CHOYP_TF2H3.1.1 m.11147 sp TF2H3_BOVIN 76.86 121 28 0 1 121 176 296 1.59E-66 206 TF2H3_BOVIN reviewed General transcription factor IIH subunit 3 (General transcription factor IIH polypeptide 3) GTF2H3 Bos taurus (Bovine) 309 nucleotide-excision repair [GO:0006289]; phosphorylation of RNA polymerase II C-terminal domain [GO:0070816]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000439; GO:0003684; GO:0005675; GO:0006289; GO:0006366; GO:0008135; GO:0046872; GO:0070816 0 0 0 PF03850; Q08CN9 CHOYP_LOC100367186.1.1 m.51436 sp ZNRF2_DANRE 44.495 218 92 5 1 190 1 217 1.59E-51 167 ZNRF2_DANRE reviewed E3 ubiquitin-protein ligase ZNRF2 (EC 6.3.2.-) (Zinc/RING finger protein 2) znrf2 zgc:152865 Danio rerio (Zebrafish) (Brachydanio rerio) 217 protein ubiquitination [GO:0016567] GO:0005765; GO:0008270; GO:0010008; GO:0016567; GO:0016874; GO:0030054; GO:0042734 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q08CN9 CHOYP_S38A7.1.1 m.2801 sp ZNRF2_DANRE 44.495 218 92 5 1 190 1 217 1.59E-51 167 ZNRF2_DANRE reviewed E3 ubiquitin-protein ligase ZNRF2 (EC 6.3.2.-) (Zinc/RING finger protein 2) znrf2 zgc:152865 Danio rerio (Zebrafish) (Brachydanio rerio) 217 protein ubiquitination [GO:0016567] GO:0005765; GO:0008270; GO:0010008; GO:0016567; GO:0016874; GO:0030054; GO:0042734 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q08E31 CHOYP_LOC100890517.2.2 m.22207 sp CREST_BOVIN 65.823 79 24 3 32 109 1 77 1.59E-23 105 CREST_BOVIN reviewed Calcium-responsive transactivator (SS18-like protein 1) SS18L1 CREST Bos taurus (Bovine) 402 "covalent chromatin modification [GO:0016569]; dendrite development [GO:0016358]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000777; GO:0000780; GO:0005634; GO:0006351; GO:0016358; GO:0016569; GO:0045893; GO:0050775; GO:0071565 0 0 0 PF05030; Q15262 CHOYP_LOC100497631.2.2 m.60455 sp PTPRK_HUMAN 30.565 566 347 11 87 619 867 1419 1.59E-71 254 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q17RP2 CHOYP_JERKL.1.1 m.16277 sp TIGD6_HUMAN 22.581 372 246 12 108 450 39 397 1.59E-24 110 TIGD6_HUMAN reviewed Tigger transposable element-derived protein 6 TIGD6 Homo sapiens (Human) 521 0 GO:0003677; GO:0005634 0 0 0 PF04218;PF03184;PF03221; Q3V096 CHOYP_LOC576698.1.1 m.32335 sp ANR42_MOUSE 53.93 458 195 3 26 473 27 478 1.59E-172 500 ANR42_MOUSE reviewed Ankyrin repeat domain-containing protein 42 Ankrd42 Mus musculus (Mouse) 527 positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091] GO:0005634; GO:0051059; GO:0051091; GO:0051092; GO:1900017 0 0 0 PF12796; Q503L9 CHOYP_LOC100633077.1.4 m.4444 sp NXN_DANRE 50.467 107 53 0 28 134 177 283 1.59E-34 127 NXN_DANRE reviewed Nucleoredoxin (EC 1.8.1.8) nxn zgc:110449 Danio rerio (Zebrafish) (Brachydanio rerio) 418 cardiovascular system development [GO:0072358]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005829; GO:0016055; GO:0030154; GO:0030178; GO:0031397; GO:0045454; GO:0047134; GO:0072358 0 0 0 PF13905; Q5F478 CHOYP_LOC755521.7.28 m.32802 sp ANR44_CHICK 31.209 910 556 12 3 861 24 914 1.59E-120 392 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5G267 CHOYP_LOC100553407.1.1 m.50013 sp NETR_MACMU 31.618 272 160 9 4 266 231 485 1.59E-28 119 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5HZL4 CHOYP_contig_013649 m.15583 sp PAF15_XENLA 59.375 96 32 3 29 117 1 96 1.59E-24 94 PAF15_XENLA reviewed PCNA-associated factor (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) paf Xenopus laevis (African clawed frog) 123 cellular response to DNA damage stimulus [GO:0006974]; centrosome organization [GO:0051297]; DNA replication [GO:0006260]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] GO:0003682; GO:0005634; GO:0006260; GO:0006974; GO:0009411; GO:0019985; GO:0048471; GO:0051297; GO:0051726 0 0 0 PF15715; Q5IS50 CHOYP_BRAFLDRAFT_83176.1.1 m.43782 sp DPP6_PANTR 35.287 819 504 13 8 818 1 801 1.59E-168 511 DPP6_PANTR reviewed Dipeptidyl aminopeptidase-like protein 6 (Dipeptidyl peptidase 6) (Dipeptidyl peptidase VI) (DPP VI) DPP6 Pan troglodytes (Chimpanzee) 803 protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379] GO:0005886; GO:0008076; GO:0008236; GO:0015459; GO:0072659; GO:1901379 0 0 0 PF00930;PF00326; Q5NVM9 CHOYP_HSPA8.1.1 m.62793 sp HSP7C_PONAB 88 250 26 1 19 268 159 404 1.59E-152 443 HSP7C_PONAB reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) HSPA8 HSC70 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 646 "mRNA processing [GO:0006397]; negative regulation of transcription, DNA-templated [GO:0045892]; RNA splicing [GO:0008380]" GO:0000974; GO:0005524; GO:0005634; GO:0005681; GO:0005730; GO:0005886; GO:0006397; GO:0008380; GO:0030529; GO:0042470; GO:0045892 0 0 0 PF00012; Q5S006 CHOYP_LRRK2.1.1 m.48637 sp LRRK2_MOUSE 40.552 471 258 10 168 632 986 1440 1.59E-93 319 LRRK2_MOUSE reviewed Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) Lrrk2 Mus musculus (Mouse) 2527 "activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; cellular protein localization [GO:0034613]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron death [GO:0070997]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of calcium-mediated signaling [GO:0050848]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron death [GO:1901214]; regulation of neuron maturation [GO:0014041]; regulation of protein kinase A signaling [GO:0010738]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle recycling [GO:0036465]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]" GO:0000149; GO:0000165; GO:0000186; GO:0000187; GO:0001933; GO:0001934; GO:0001948; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004708; GO:0005096; GO:0005524; GO:0005525; GO:0005615; GO:0005622; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005901; GO:0005902; GO:0006468; GO:0006897; GO:0006914; GO:0006979; GO:0007005; GO:0007030; GO:0007040; GO:0007264; GO:0007528; GO:0008021; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010738; GO:0010955; GO:0014041; GO:0015631; GO:0016234; GO:0016242; GO:0016301; GO:0016310; GO:0017048; GO:0017075; GO:0018105; GO:0018107; GO:0019722; GO:0021772; GO:0022028; GO:0030054; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030529; GO:0030672; GO:0031398; GO:0031410; GO:0031966; GO:0032091; GO:0032092; GO:0032403; GO:0032436; GO:0032473; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034613; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0035751; GO:0036465; GO:0036479; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0044325; GO:0044753; GO:0044754; GO:0045121; GO:0045202; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0050848; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060079; GO:0060159; GO:0060161; GO:0060828; GO:0061001; GO:0070062; GO:0070997; GO:0071287; GO:0072593; GO:0090263; GO:0090394; GO:0097487; GO:0098794; GO:1901214; GO:1901215; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902902; GO:1903125; GO:1903206; GO:1903215; GO:1903351; GO:1904713; GO:1904887; GO:1990909; GO:2000172; GO:2000300 0 0 0 PF16095;PF12799;PF13855;PF00069;PF08477; Q64429 CHOYP_CP1B1.1.1 m.50003 sp CP1B1_MOUSE 30.879 489 315 11 57 528 43 525 1.59E-69 235 CP1B1_MOUSE reviewed Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (Cytochrome P450CMEF) (Cytochrome P450EF) Cyp1b1 Cyp1-b1 Mus musculus (Mouse) 543 angiogenesis [GO:0001525]; arachidonic acid metabolic process [GO:0019369]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cellular aromatic compound metabolic process [GO:0006725]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to organic cyclic compound [GO:0071407]; collagen fibril organization [GO:0030199]; endothelial cell-cell adhesion [GO:0071603]; endothelial cell migration [GO:0043542]; estrogen metabolic process [GO:0008210]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; membrane lipid catabolic process [GO:0046466]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to toxic substance [GO:0009636]; retinal blood vessel morphogenesis [GO:0061304]; retinal metabolic process [GO:0042574]; retina vasculature development in camera-type eye [GO:0061298]; retinol metabolic process [GO:0042572]; steroid metabolic process [GO:0008202]; toxin metabolic process [GO:0009404]; trabecular meshwork development [GO:0002930]; xenobiotic metabolic process [GO:0006805] GO:0001525; GO:0002930; GO:0004497; GO:0005506; GO:0005739; GO:0005789; GO:0006725; GO:0006805; GO:0006809; GO:0007155; GO:0008202; GO:0008210; GO:0008285; GO:0008631; GO:0009404; GO:0009636; GO:0010575; GO:0016712; GO:0019369; GO:0020037; GO:0030199; GO:0030336; GO:0031090; GO:0032088; GO:0033629; GO:0042572; GO:0042574; GO:0043065; GO:0043542; GO:0045766; GO:0046427; GO:0046466; GO:0048514; GO:0061298; GO:0061304; GO:0070301; GO:0070330; GO:0071407; GO:0071603; GO:2000377 0 0 0 PF00067; Q6PIJ4 CHOYP_NFRKB.1.1 m.18027 sp NFRKB_MOUSE 43.365 731 358 16 23 746 26 707 1.59E-167 537 NFRKB_MOUSE reviewed Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B) Nfrkb Mus musculus (Mouse) 1296 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0002020; GO:0003677; GO:0005634; GO:0005654; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0031011 0 0 0 PF14465; Q6YHK3 CHOYP_PHUM_PHUM289860.1.1 m.44778 sp CD109_HUMAN 24.208 1578 977 54 69 1605 17 1416 1.59E-107 379 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q6ZPT1 CHOYP_BRAFLDRAFT_223623.1.1 m.11202 sp KLHL9_MOUSE 34.251 581 371 6 30 606 21 594 1.59E-120 373 KLHL9_MOUSE reviewed Kelch-like protein 9 Klhl9 Kiaa1354 Mus musculus (Mouse) 617 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q868T3 CHOYP_CCAPR1.1.1 m.51863 sp CCAPR_DROME 37.11 353 181 7 13 359 101 418 1.59E-66 221 CCAPR_DROME reviewed Cardioacceleratory peptide receptor (Crustacean cardioactive peptide receptor) CCAP-R CcapR CG33344 Drosophila melanogaster (Fruit fly) 495 "ecdysis, chitin-based cuticle [GO:0018990]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]" GO:0005000; GO:0005887; GO:0007186; GO:0007218; GO:0008188; GO:0016021; GO:0018990 0 0 0 PF00001; Q8NEF3 CHOYP_CCDC112.1.1 m.381 sp CC112_HUMAN 41.95 441 245 3 48 483 1 435 1.59E-108 332 CC112_HUMAN reviewed Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1) CCDC112 MBC1 Homo sapiens (Human) 446 0 0 0 0 0 0 Q8VCV9 CHOYP_NAGT1.1.1 m.8857 sp MF4B1_MOUSE 26.353 425 256 10 8 425 4 378 1.59E-31 129 MF4B1_MOUSE reviewed Sodium-dependent glucose transporter 1A (Major facilitator superfamily domain-containing protein 4B1) Mfsd4b1 Naglt1a Mus musculus (Mouse) 425 carbohydrate transport [GO:0008643]; sodium ion transport [GO:0006814] GO:0006814; GO:0008643; GO:0015293; GO:0016021; GO:0016324 0 0 cd06174; PF07690; Q8VHE6 CHOYP_LOC577371.2.2 m.67037 sp DYH5_MOUSE 43.511 131 56 1 16 146 20 132 1.59E-25 104 DYH5_MOUSE reviewed "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (mDNAH5) (Ciliary dynein heavy chain 5)" Dnah5 Dnahc5 Mus musculus (Mouse) 4621 cilium assembly [GO:0042384]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]; sperm motility [GO:0030317] GO:0003341; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0005930; GO:0007368; GO:0007507; GO:0016887; GO:0021670; GO:0030317; GO:0036157; GO:0036158; GO:0042384 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8WZ42 CHOYP_DVIR_GJ13257.1.1 m.6914 sp TITIN_HUMAN 26.087 207 122 8 44 250 6545 6720 1.59E-06 53.5 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q95NR9 CHOYP_CALM.30.50 m.44953 sp CALM_METSE 96.644 149 5 0 1 149 1 149 1.59E-102 292 CALM_METSE reviewed Calmodulin (CaM) 0 Metridium senile (Brown sea anemone) (Frilled sea anemone) 149 0 GO:0005509 0 0 0 PF13499; Q95NR9 CHOYP_CALM.42.50 m.56134 sp CALM_METSE 96.644 149 5 0 1 149 1 149 1.59E-102 292 CALM_METSE reviewed Calmodulin (CaM) 0 Metridium senile (Brown sea anemone) (Frilled sea anemone) 149 0 GO:0005509 0 0 0 PF13499; Q96LR7 CHOYP_BRAFLDRAFT_117028.1.1 m.26596 sp CB050_HUMAN 32.71 107 72 0 40 146 53 159 1.59E-17 77.4 CB050_HUMAN reviewed Uncharacterized protein C2orf50 C2orf50 Homo sapiens (Human) 162 0 0 0 0 0 0 Q9BPW9 CHOYP_BRAFLDRAFT_290492.1.1 m.21887 sp DHRS9_HUMAN 38.095 315 191 3 6 320 5 315 1.59E-75 237 DHRS9_HUMAN reviewed Dehydrogenase/reductase SDR family member 9 (EC 1.1.-.-) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL) (Retinol dehydrogenase 15) (Short chain dehydrogenase/reductase family 9C member 4) (Short-chain dehydrogenase/reductase retSDR8) (Tracheobronchial epithelial cell-specific retinol dehydrogenase) (RDH-TBE) DHRS9 RDH15 SDR9C4 UNQ835/PRO1773 Homo sapiens (Human) 319 9-cis-retinoic acid biosynthetic process [GO:0042904]; androgen metabolic process [GO:0008209]; epithelial cell differentiation [GO:0030855]; progesterone metabolic process [GO:0042448]; retinoic acid biosynthetic process [GO:0002138]; retinol metabolic process [GO:0042572] GO:0002138; GO:0004022; GO:0004745; GO:0005789; GO:0008209; GO:0016854; GO:0030176; GO:0030855; GO:0031090; GO:0042448; GO:0042572; GO:0042904; GO:0047035 0 0 0 PF00106; Q9BXF3 CHOYP_CECR2.2.3 m.13613 sp CECR2_HUMAN 59.146 164 62 2 3 166 11 169 1.59E-55 217 CECR2_HUMAN reviewed Cat eye syndrome critical region protein 2 CECR2 KIAA1740 Homo sapiens (Human) 1484 apoptotic DNA fragmentation [GO:0006309]; ATP-dependent chromatin remodeling [GO:0043044]; covalent chromatin modification [GO:0016569]; cytokinesis [GO:0000910]; cytoskeleton organization [GO:0007010]; execution phase of apoptosis [GO:0097194]; neural tube development [GO:0021915]; vesicle-mediated transport [GO:0016192] GO:0000910; GO:0005634; GO:0006309; GO:0007010; GO:0016192; GO:0016569; GO:0021915; GO:0043044; GO:0090537; GO:0097194 0 0 0 PF00439; Q9CQH8 CHOYP_RPP14.1.2 m.10809 sp RPP14_MOUSE 39.623 106 62 2 9 113 13 117 1.59E-16 72.8 RPP14_MOUSE reviewed Ribonuclease P protein subunit p14 (EC 3.1.26.5) Rpp14 Mus musculus (Mouse) 122 tRNA processing [GO:0008033] GO:0004526; GO:0005730; GO:0005737; GO:0005739; GO:0008033 0 0 0 PF01900; Q9D4B2 CHOYP_LOC100212543.1.1 m.29317 sp TTC25_MOUSE 28.058 278 162 5 19 296 13 252 1.59E-22 103 TTC25_MOUSE reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) Ttc25 Mus musculus (Mouse) 624 0 GO:0005737 0 0 0 PF13181; Q9DBB5 CHOYP_LOC100370061.1.1 m.41505 sp IF4E3_MOUSE 53.631 179 83 0 50 228 26 204 1.59E-73 225 IF4E3_MOUSE reviewed Eukaryotic translation initiation factor 4E type 3 (eIF-4E type 3) (eIF-4E3) (eIF4E type 3) (eIF4E-3) Eif4e3 Mus musculus (Mouse) 207 regulation of translation [GO:0006417] GO:0003743; GO:0005737; GO:0005845; GO:0006417 0 0 0 PF01652; Q9ESN6 CHOYP_TRIM3.15.58 m.23922 sp TRIM2_MOUSE 29.487 234 143 11 80 304 523 743 1.59E-13 74.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HCS2 CHOYP_LOC100538434.1.1 m.10606 sp CP4FC_HUMAN 40.272 514 280 10 1 494 14 520 1.59E-140 417 CP4FC_HUMAN reviewed Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12) CYP4F12 UNQ568/PRO1129 Homo sapiens (Human) 524 arachidonic acid metabolic process [GO:0019369]; drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; leukotriene B4 catabolic process [GO:0036101]; long-chain fatty acid metabolic process [GO:0001676]; oxidation-reduction process [GO:0055114]; pressure natriuresis [GO:0003095]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360] GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0005506; GO:0005737; GO:0005789; GO:0008392; GO:0016021; GO:0016324; GO:0017144; GO:0018685; GO:0019369; GO:0019373; GO:0019825; GO:0020037; GO:0031090; GO:0036101; GO:0042360; GO:0043231; GO:0050051; GO:0055078; GO:0055114; GO:0070330 0 0 0 PF00067; Q9I8C7 CHOYP_LOC576549.1.1 m.61371 sp ACH10_CHICK 28.274 336 228 6 18 344 20 351 1.59E-38 147 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9JLC8 CHOYP_SACS.17.17 m.66140 sp SACS_MOUSE 23.632 457 309 14 79 513 3123 3561 1.59E-19 96.7 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9MZE0 CHOYP_ISCW_ISCW020550.1.2 m.3370 sp C1QBP_CHLAE 34.01 197 114 7 57 242 73 264 1.59E-18 85.5 C1QBP_CHLAE reviewed "Complement component 1 Q subcomponent-binding protein, mitochondrial (Globular head receptor of C1 complement protein) (Mitochondrial matrix protein p32)" C1QBP Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) 282 "apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; mature ribosome assembly [GO:0042256]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0000122; GO:0001849; GO:0003714; GO:0003729; GO:0005540; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005759; GO:0005886; GO:0006351; GO:0006397; GO:0006915; GO:0006958; GO:0008380; GO:0014065; GO:0016032; GO:0030449; GO:0030984; GO:0031690; GO:0032689; GO:0032695; GO:0039534; GO:0039536; GO:0042256; GO:0043065; GO:0045087; GO:0045785; GO:0048025; GO:0050687; GO:0051897; GO:0070131; GO:0090023; GO:0097177; GO:1900026; GO:1901165; GO:2000510 0 0 0 PF02330; Q9R1R2 CHOYP_LOC100891315.1.1 m.1893 sp TRIM3_MOUSE 28.221 163 83 7 29 171 11 159 1.59E-14 75.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UPS8 CHOYP_LOC100371645.1.2 m.10215 sp ANR26_HUMAN 28.276 870 524 22 1130 1936 716 1548 1.59E-54 215 ANR26_HUMAN reviewed Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) 1709 0 GO:0005813 0 0 0 PF00023;PF12796;PF12001; Q9V3Y3 CHOYP_LOC658370.1.2 m.6453 sp DFP_DROME 32.215 149 81 8 21 165 11 143 1.59E-09 57.8 DFP_DROME reviewed Defense protein l(2)34Fc l(2)34Fc CG7532 Drosophila melanogaster (Fruit fly) 159 defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087]; negative regulation of immune response [GO:0050777] GO:0005576; GO:0042742; GO:0042832; GO:0045087; GO:0050777 0 0 cd08544; PF02014; Q9W0T1 CHOYP_LOC575132.1.2 m.1648 sp NU301_DROME 40.584 308 154 10 1 284 1 303 1.59E-53 190 NU301_DROME reviewed Nucleosome-remodeling factor subunit NURF301 (Enhancer of bithorax) (Nucleosome-remodeling factor 215 kDa subunit) (NURF-215) E(bx) CG32346 CG7022 Nurf301 Drosophila melanogaster (Fruit fly) 2669 "chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; dendrite morphogenesis [GO:0048813]; ecdysone receptor-mediated signaling pathway [GO:0035076]; hemopoiesis [GO:0030097]; lateral inhibition [GO:0046331]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of innate immune response [GO:0045824]; negative regulation of JAK-STAT cascade [GO:0046426]; nucleosome mobilization [GO:0042766]; positive regulation of Notch signaling pathway [GO:0045747]; pupariation [GO:0035073]; regulation of gene expression [GO:0010468]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sensory perception of pain [GO:0019233]; spermatid differentiation [GO:0048515]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0006325; GO:0006338; GO:0006351; GO:0006357; GO:0007095; GO:0008270; GO:0010468; GO:0016569; GO:0016589; GO:0016922; GO:0019233; GO:0030097; GO:0035064; GO:0035073; GO:0035076; GO:0042766; GO:0045747; GO:0045824; GO:0046331; GO:0046426; GO:0048515; GO:0048813; GO:0070577 0 0 0 PF00439;PF02791;PF00628;PF15612; A2RU49 CHOYP_DVIR_GJ17679.3.3 m.63197 sp HYKK_HUMAN 33.427 356 216 7 27 381 25 360 1.60E-56 192 HYKK_HUMAN reviewed Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) HYKK AGPHD1 Homo sapiens (Human) 373 lysine catabolic process [GO:0006554] GO:0005759; GO:0006554; GO:0047992 0 0 0 PF01636; B8DKP2 CHOYP_PMAR_PMAR019172.1.1 m.2563 sp PHNX_DESVM 40.293 273 160 3 9 281 8 277 1.60E-67 214 PHNX_DESVM reviewed Phosphonoacetaldehyde hydrolase (Phosphonatase) (EC 3.11.1.1) (Phosphonoacetaldehyde phosphonohydrolase) phnX DvMF_0514 Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637) 280 organic phosphonate catabolic process [GO:0019700] GO:0000287; GO:0019700; GO:0050194 0 0 0 PF13419; D3YWJ0 CHOYP_BRAFLDRAFT_129807.1.1 m.47245 sp SLIP_MOUSE 33.333 279 158 9 1399 1659 98 366 1.60E-28 129 SLIP_MOUSE reviewed Nuclear GTPase SLIP-GC (EC 3.6.1.-) (Speckled-like pattern in the germinal center) Nuggc Mus musculus (Mouse) 796 cellular response to DNA damage stimulus [GO:0006974]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0005525; GO:0005634; GO:0006974; GO:0016446; GO:0016607; GO:0016787 0 0 0 PF00350; O14082 CHOYP_LOC100632738.1.1 m.4911 sp YEAH_SCHPO 36.554 383 218 10 6 376 36 405 1.60E-74 239 YEAH_SCHPO reviewed Uncharacterized protein UNK4.17 SPAC2E11.17 SPACUNK4.17 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 406 oxidation-reduction process [GO:0055114] GO:0005634; GO:0005829; GO:0016491; GO:0055114 0 0 0 PF01408;PF08635; O15973 CHOYP_LOC100888622.1.1 m.58355 sp OPSD1_MIZYE 26.316 342 237 7 48 386 55 384 1.60E-25 112 OPSD1_MIZYE reviewed "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 499 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0004930; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; O35125 CHOYP_LOC100749506.1.1 m.8951 sp LRC23_MOUSE 57.483 294 123 2 36 329 31 322 1.60E-113 336 LRC23_MOUSE reviewed Leucine-rich repeat-containing protein 23 (Leucine-rich protein B7) Lrrc23 Lrpb7 Mus musculus (Mouse) 340 0 0 0 0 0 PF13516; O43586 CHOYP_PSTPIP1A.1.1 m.65313 sp PPIP1_HUMAN 28.029 421 294 6 1 420 1 413 1.60E-42 157 PPIP1_HUMAN reviewed Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) PSTPIP1 CD2BP1 Homo sapiens (Human) 416 cell adhesion [GO:0007155]; cell migration [GO:0016477]; endocytosis [GO:0006897]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; signal transduction [GO:0007165] GO:0001931; GO:0005829; GO:0005856; GO:0005886; GO:0006897; GO:0006954; GO:0007155; GO:0007165; GO:0016020; GO:0016477; GO:0030027; GO:0032154; GO:0045087; GO:0048471 0 0 0 PF00611;PF14604; O74549 CHOYP_LOC100374301.1.1 m.31273 sp UBC12_SCHPO 39.063 128 65 5 47 169 53 172 1.60E-21 89.7 UBC12_SCHPO reviewed NEDD8-conjugating enzyme ubc12 (EC 6.3.2.-) (RUB1-conjugating enzyme) (RUB1-protein ligase) (Ubiquitin carrier protein 12) ubc12 SPCC777.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 177 protein neddylation [GO:0045116] GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0016874; GO:0019788; GO:0045116 PATHWAY: Protein modification; protein neddylation. 0 0 PF00179; O75095 CHOYP_LOC101242430.1.2 m.23519 sp MEGF6_HUMAN 37.864 103 57 5 186 287 1282 1378 1.60E-06 54.3 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P04323 CHOYP_LOC100142324.1.1 m.9181 sp POL3_DROME 33.122 631 380 16 367 973 16 628 1.60E-91 323 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P04570 CHOYP_LOC725703.1.1 m.31182 sp SCP2_BRALA 26.455 189 119 5 4 177 2 185 1.60E-12 67 SCP2_BRALA reviewed "Sarcoplasmic calcium-binding proteins II, V, VI, and VII (SCP II) (SCP V) (SCP VI) (SCP VII)" 0 Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum) 185 0 GO:0005509 0 0 0 PF13833; P07572 CHOYP_LOC100495679.2.2 m.56913 sp POL_MPMV 23.256 301 188 10 186 477 49 315 1.60E-09 64.7 POL_MPMV reviewed Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) 867 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P12276 CHOYP_FASN.2.4 m.18642 sp FAS_CHICK 30.619 1130 690 27 1 1056 1 1110 1.60E-133 468 FAS_CHICK reviewed Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Gallus gallus (Chicken) 2512 fatty acid biosynthetic process [GO:0006633]; lactate metabolic process [GO:0006089]; positive regulation of appetite [GO:0032100] GO:0003697; GO:0004312; GO:0004313; GO:0004314; GO:0004315; GO:0004316; GO:0004317; GO:0004319; GO:0004320; GO:0005623; GO:0006089; GO:0006633; GO:0016295; GO:0016296; GO:0031177; GO:0032100; GO:0047117; GO:0047451; GO:0102132 0 0 0 PF00698;PF00107;PF16197;PF00109;PF02801;PF08659;PF00550;PF14765;PF00975; P27085 CHOYP_BRAFLDRAFT_264234.2.2 m.7063 sp RS26_OCTVU 86.957 115 13 1 36 148 1 115 1.60E-68 206 RS26_OCTVU reviewed 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) 127 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01283; P37967 CHOYP_CHLE.3.3 m.42461 sp PNBA_BACSU 41.053 190 106 3 27 211 4 192 1.60E-37 148 PNBA_BACSU reviewed Para-nitrobenzyl esterase (EC 3.1.1.-) (Intracellular esterase B) (PNB carboxy-esterase) (PNBCE) pnbA estB BSU34390 Bacillus subtilis (strain 168) 489 0 GO:0004104 0 0 0 PF00135; P47911 CHOYP_BRAFLDRAFT_114734.7.8 m.50126 sp RL6_MOUSE 60 210 70 3 30 238 100 296 1.60E-76 236 RL6_MOUSE reviewed 60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) Rpl6 Mus musculus (Mouse) 296 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; P53708 CHOYP_ITA8.1.3 m.52339 sp ITA8_HUMAN 26.067 1101 692 44 24 1069 30 1063 1.60E-67 250 ITA8_HUMAN reviewed Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Homo sapiens (Human) 1063 brain development [GO:0007420]; cell-matrix adhesion [GO:0007160]; cell projection organization [GO:0030030]; establishment of protein localization [GO:0045184]; extracellular matrix organization [GO:0030198]; inner ear morphogenesis [GO:0042472]; integrin-mediated signaling pathway [GO:0007229]; kidney development [GO:0001822]; memory [GO:0007613]; mesodermal cell differentiation [GO:0048333]; metanephros development [GO:0001656]; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000721]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; single organismal cell-cell adhesion [GO:0016337]; smooth muscle tissue development [GO:0048745]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0001656; GO:0001822; GO:0005783; GO:0005886; GO:0005925; GO:0007160; GO:0007229; GO:0007420; GO:0007613; GO:0008305; GO:0009986; GO:0014069; GO:0016337; GO:0030030; GO:0030198; GO:0030511; GO:0032591; GO:0034446; GO:0034678; GO:0042472; GO:0043204; GO:0045177; GO:0045184; GO:0046872; GO:0048333; GO:0048745; GO:2000721 0 0 0 PF01839;PF00357;PF08441; P54366 CHOYP_GSC.1.1 m.43600 sp GSC_DROME 87.879 66 8 0 96 161 280 345 1.60E-32 127 GSC_DROME reviewed Homeobox protein goosecoid Gsc CG2851 Drosophila melanogaster (Fruit fly) 415 "multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]" GO:0001078; GO:0005634; GO:0007275; GO:0042803; GO:0043565; GO:0045892; GO:0046982 0 0 0 PF00046; P55211 CHOYP_contig_049829 m.59213 sp CASP9_HUMAN 40.244 82 46 2 17 96 17 97 1.60E-06 51.6 CASP9_HUMAN reviewed Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] CASP9 MCH6 Homo sapiens (Human) 416 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; aging [GO:0007568]; apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glial cell apoptotic process [GO:0034349]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; platelet formation [GO:0030220]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of response to DNA damage stimulus [GO:2001020]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; signal transduction in response to DNA damage [GO:0042770] GO:0004197; GO:0005634; GO:0005739; GO:0005829; GO:0006915; GO:0006974; GO:0007568; GO:0008047; GO:0008233; GO:0008630; GO:0008635; GO:0017124; GO:0019901; GO:0030220; GO:0032025; GO:0032355; GO:0032496; GO:0034349; GO:0034644; GO:0042770; GO:0043293; GO:0043525; GO:0046677; GO:0071549; GO:0097153; GO:0097192; GO:2001020 0 0 0 PF00619; P83425 CHOYP_LOC100077749.1.1 m.63673 sp HIP_MYTED 31.008 129 85 3 24 149 85 212 1.60E-09 57.4 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P86854 CHOYP_BRAFLDRAFT_129759.2.2 m.30082 sp PLCL_MYTGA 31.579 133 81 5 50 178 30 156 1.60E-13 68.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q01414 CHOYP_CRE-ETS-5.1.1 m.28112 sp ERG_LYTVA 66.667 99 33 0 114 212 2 100 1.60E-43 149 ERG_LYTVA reviewed Transcriptional regulator ERG homolog (Fragment) ERG Lytechinus variegatus (Green sea urchin) (Variegated urchin) 173 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565 0 0 0 PF00178; Q04786 CHOYP_NEMVEDRAFT_V1G241973.1.2 m.7498 sp HEX_VIBVL 35.813 793 443 17 22 774 76 842 1.60E-164 501 HEX_VIBVL reviewed Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus 847 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; Q09575 CHOYP_LOC100377433.1.1 m.55303 sp YRD6_CAEEL 30.827 266 180 3 10 274 792 1054 1.60E-38 149 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q09JW2 CHOYP_RL17.7.7 m.57535 sp RL17_ARGMO 77.246 167 38 0 1 167 1 167 1.60E-93 274 RL17_ARGMO reviewed 60S ribosomal protein L17 RpL17 Argas monolakensis (Mono lake bird tick) 185 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 cd00336; PF00237; Q16527 CHOYP_MLP2.3.4 m.57755 sp CSRP2_HUMAN 44.845 194 98 3 175 364 4 192 1.60E-53 178 CSRP2_HUMAN reviewed Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (LIM domain only protein 5) (LMO-5) (Smooth muscle cell LIM protein) (SmLIM) CSRP2 LMO5 SMLIM Homo sapiens (Human) 193 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; myoblast differentiation [GO:0045445] GO:0005634; GO:0005925; GO:0007275; GO:0008270; GO:0030154; GO:0045445 0 0 0 PF00412; Q20681 CHOYP_CRE_19768.1.1 m.46379 sp BAT38_CAEEL 40.625 96 55 2 15 109 229 323 1.60E-13 72 BAT38_CAEEL reviewed BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans 387 0 0 0 0 0 PF00651;PF00917; Q27294 CHOYP_ISCW_ISCW015311.1.1 m.19101 sp CAZ_DROME 51.136 88 43 0 1 88 115 202 1.60E-24 98.2 CAZ_DROME reviewed RNA-binding protein cabeza (P19) (Sarcoma-associated RNA-binding fly homolog) caz SARFH CG3606 Drosophila melanogaster (Fruit fly) 399 "adult locomotory behavior [GO:0008344]; compound eye development [GO:0048749]; larval locomotory behavior [GO:0008345]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; synaptic growth at neuromuscular junction [GO:0051124]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000166; GO:0000398; GO:0003729; GO:0005634; GO:0005654; GO:0005669; GO:0006367; GO:0008270; GO:0008344; GO:0008345; GO:0045887; GO:0048749; GO:0051124; GO:0071013 0 0 0 PF00076;PF00641; Q28864 CHOYP_LOC100880258.1.1 m.16655 sp TFPI1_MACMU 41.353 133 64 2 749 869 46 176 1.60E-24 108 TFPI1_MACMU reviewed Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI TFPI1 Macaca mulatta (Rhesus macaque) 304 blood coagulation [GO:0007596] GO:0004867; GO:0005615; GO:0007596; GO:0009986 0 0 0 PF00014; Q42404 CHOYP_LOC662320.2.2 m.19454 sp RU17_ARATH 56.364 110 40 3 1 107 192 296 1.60E-20 91.7 RU17_ARATH reviewed U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) RNU1 At3g50670 T3A5.50 Arabidopsis thaliana (Mouse-ear cress) 427 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000243; GO:0000398; GO:0003729; GO:0005634; GO:0005685; GO:0016607; GO:0030619; GO:0071004; GO:0071011 0 0 0 PF00076;PF12220; Q5JXM2 CHOYP_LOC100373794.3.5 m.37881 sp MET24_HUMAN 31.609 174 103 5 330 490 131 301 1.60E-13 75.5 MET24_HUMAN reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) METTL24 C6orf186 Homo sapiens (Human) 366 0 GO:0005576; GO:0008168 0 0 0 PF13383; Q5PQ59 CHOYP_LOC101061324.1.1 m.11670 sp ALKB6_XENLA 54.971 171 75 2 1 170 69 238 1.60E-60 190 ALKB6_XENLA reviewed Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 6) alkbh6 Xenopus laevis (African clawed frog) 240 0 GO:0005634; GO:0005737; GO:0046872; GO:0051213 0 0 0 PF13532; Q5R4P1 CHOYP_ATL2.1.1 m.14737 sp ATLA1_PONAB 40.488 410 233 4 47 454 34 434 1.60E-104 327 ATLA1_PONAB reviewed Atlastin-1 (EC 3.6.5.-) ATL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; protein homooligomerization [GO:0051260] GO:0000137; GO:0000139; GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0005794; GO:0007029; GO:0007409; GO:0016021; GO:0030424; GO:0042802; GO:0051260 0 0 0 PF02263; Q5RJY2 CHOYP_LOC101172881.2.2 m.65793 sp G2E3_MOUSE 31.152 382 226 10 256 619 322 684 1.60E-45 175 G2E3_MOUSE reviewed G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) G2e3 Kiaa1333 Mus musculus (Mouse) 716 apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0001824; GO:0005730; GO:0005737; GO:0006915; GO:0008270; GO:0016874; GO:0061630; GO:2001243 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q5SUV2 CHOYP_LOC579832.2.2 m.47454 sp MYBPP_MOUSE 35.135 629 365 13 45 661 2 599 1.60E-104 348 MYBPP_MOUSE reviewed MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1) Mycbpap Amap1 Mus musculus (Mouse) 932 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0007268; GO:0007275; GO:0007283; GO:0016020; GO:0030154 0 0 0 PF14646; Q5XIJ8 CHOYP_LOC585839.1.1 m.51865 sp CCD65_RAT 48.344 453 234 0 25 477 13 465 1.60E-148 437 CCD65_RAT reviewed Coiled-coil domain-containing protein 65 Ccdc65 Rattus norvegicus (Rat) 502 0 0 0 0 0 0 Q61184 CHOYP_LOC100375417.1.1 m.61779 sp MTR1A_MOUSE 25.256 293 205 5 40 326 36 320 1.60E-25 108 MTR1A_MOUSE reviewed Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) Mtnr1a Mus musculus (Mouse) 353 aging [GO:0007568]; camera-type eye development [GO:0043010]; cell surface receptor signaling pathway [GO:0007166]; circadian rhythm [GO:0007623]; negative regulation of insulin secretion [GO:0046676]; positive regulation of cGMP biosynthetic process [GO:0030828] GO:0005887; GO:0007166; GO:0007568; GO:0007623; GO:0008502; GO:0030828; GO:0042562; GO:0043010; GO:0043025; GO:0043235; GO:0046676; GO:0097159 0 0 0 PF00001; Q6DCQ5 CHOYP_M212A.1.1 m.36199 sp M212B_XENLA 26.702 191 117 9 203 377 173 356 1.60E-07 57.8 M212B_XENLA reviewed Protein mab-21-like 2-B mab21l2-b Xenopus laevis (African clawed frog) 359 eye development [GO:0001654] GO:0001654; GO:0005634 0 0 0 PF03281; Q6DJ08 CHOYP_ENO.2.2 m.23026 sp S2538_XENTR 53.901 282 128 2 7 286 20 301 1.60E-102 304 S2538_XENTR reviewed Solute carrier family 25 member 38 slc25a38 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 302 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; translation [GO:0006412] GO:0003735; GO:0005215; GO:0005743; GO:0006412; GO:0006783; GO:0016021; GO:0030218 0 0 0 PF00153; Q8BGD9 CHOYP_EIF4BB.1.1 m.51066 sp IF4B_MOUSE 43.284 268 110 6 1 226 1 268 1.60E-41 163 IF4B_MOUSE reviewed Eukaryotic translation initiation factor 4B (eIF-4B) Eif4b Mus musculus (Mouse) 611 cytoplasmic translation [GO:0002181]; eukaryotic translation initiation factor 4F complex assembly [GO:0097010]; formation of translation preinitiation complex [GO:0001731] GO:0000166; GO:0001731; GO:0002181; GO:0003743; GO:0005844; GO:0016281; GO:0033592; GO:0034057; GO:0043024; GO:0044822; GO:0097010 0 0 0 PF00076; Q8BGX7 CHOYP_K0146.1.1 m.49380 sp SPIDR_MOUSE 30.623 369 207 14 12 360 562 901 1.60E-21 100 SPIDR_MOUSE reviewed DNA repair-scaffolding protein (Scaffolding protein involved in DNA repair) Spidr Kiaa0146 Mus musculus (Mouse) 933 cellular response to camptothecin [GO:0072757]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to hydroxyurea [GO:0072711]; cellular response to ionizing radiation [GO:0071479]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of protein complex assembly [GO:0031334]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of establishment of protein localization to chromosome [GO:0070202] GO:0000228; GO:0000724; GO:0005654; GO:0006974; GO:0010569; GO:0031334; GO:0070202; GO:0071479; GO:0072711; GO:0072757; GO:2000781 0 0 0 PF14950;PF14951; Q8ISN9 CHOYP_RS25.8.11 m.37403 sp RS25_BRABE 75 76 18 1 55 130 36 110 1.60E-34 119 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8R015 CHOYP_NEMVEDRAFT_V1G215851.2.2 m.18130 sp BL1S5_MOUSE 34.459 148 94 1 11 155 37 184 1.60E-21 88.6 BL1S5_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) Bloc1s5 Mu Muted Mus musculus (Mouse) 185 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; developmental pigmentation [GO:0048066]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; otolith morphogenesis [GO:0032474]; positive regulation of pigment cell differentiation [GO:0050942]; vesicle-mediated transport [GO:0016192] GO:0008089; GO:0016192; GO:0016197; GO:0030133; GO:0031083; GO:0031175; GO:0032402; GO:0032474; GO:0035646; GO:0048066; GO:0048490; GO:0050942; GO:1904115 0 0 0 PF14942; Q8WND5 CHOYP_ELP1.1.2 m.21300 sp ELP1_RABIT 43.467 398 218 3 1 397 942 1333 1.60E-92 308 ELP1_RABIT reviewed Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) IKBKAP ELP1 IKAP Oryctolagus cuniculus (Rabbit) 1333 "positive regulation of cell migration [GO:0030335]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; tRNA wobble uridine modification [GO:0002098]" GO:0002098; GO:0005737; GO:0006351; GO:0006357; GO:0008023; GO:0008607; GO:0030335; GO:0033588 0 0 0 PF04762; Q91677 CHOYP_GATA4.1.2 m.10901 sp GATA4_XENLA 47.632 359 104 15 100 421 1 312 1.60E-86 275 GATA4_XENLA reviewed Transcription factor GATA-4 (GATA-binding factor 4) (xGATA-4) gata4 Xenopus laevis (African clawed frog) 392 "cardiac muscle tissue development [GO:0048738]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0008270; GO:0043565; GO:0044212; GO:0045893; GO:0045944; GO:0048738 0 0 0 PF00320;PF05349; Q9BRD0 CHOYP_BUD13.1.1 m.12310 sp BUD13_HUMAN 56.028 141 58 2 56 192 479 619 1.60E-40 147 BUD13_HUMAN reviewed BUD13 homolog BUD13 Homo sapiens (Human) 619 "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0005634; GO:0006406; GO:0044822; GO:0070274 0 0 0 PF09736; Q9CQL4 CHOYP_MRPL20.1.1 m.43525 sp RM20_MOUSE 40 155 80 4 22 174 1 144 1.60E-27 104 RM20_MOUSE reviewed "39S ribosomal protein L20, mitochondrial (L20mt) (MRP-L20)" Mrpl20 Mus musculus (Mouse) 149 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005739; GO:0005761; GO:0005762; GO:0006412; GO:0019843; GO:0044822 0 0 cd07026; PF00453; Q9CZJ2 CHOYP_HSPA12A.6.27 m.22806 sp HS12B_MOUSE 28.079 203 134 4 1 194 485 684 1.60E-20 91.7 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9NRG9 CHOYP_AAAS.1.3 m.22164 sp AAAS_HUMAN 61.314 137 53 0 42 178 129 265 1.60E-51 176 AAAS_HUMAN reviewed Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) 546 fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; learning [GO:0007612]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of nucleocytoplasmic transport [GO:0046822]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005813; GO:0006406; GO:0006409; GO:0006913; GO:0007077; GO:0007612; GO:0009566; GO:0010827; GO:0015031; GO:0016020; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031965; GO:0046822; GO:0075733; GO:1900034 0 0 0 PF00400; Q9P1Z9 CHOYP_LOC100369255.2.3 m.26489 sp CC180_HUMAN 32.831 597 393 3 1 596 184 773 1.60E-99 357 CC180_HUMAN reviewed Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) 1646 0 GO:0016021; GO:0070062 0 0 0 PF14643;PF14644; Q9UPN9 CHOYP_BRAFLDRAFT_93989.3.5 m.39214 sp TRI33_HUMAN 25.769 260 155 9 14 257 125 362 1.60E-12 74.7 TRI33_HUMAN reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) 1127 "negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0045892; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q9WTK3 CHOYP_LOC664158.1.2 m.10881 sp GPAA1_MOUSE 34.97 672 372 12 1 662 1 617 1.60E-126 390 GPAA1_MOUSE reviewed Glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1) (GAA1 protein homolog) (mGAA1) Gpaa1 Gaa1 Mus musculus (Mouse) 621 attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506] GO:0003923; GO:0005887; GO:0006506; GO:0016020; GO:0016255; GO:0034235; GO:0042765 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF04114; Q9XWB9 CHOYP_CRE_17652.1.1 m.64700 sp BAT36_CAEEL 32.99 97 64 1 12 108 159 254 1.60E-09 60.1 BAT36_CAEEL reviewed BTB and MATH domain-containing protein 36 bath-36 Y75B12B.4 Caenorhabditis elegans 320 0 0 0 0 0 PF00651;PF00917; Q9Z221 CHOYP_LOC100377856.2.2 m.43339 sp PMFBP_RAT 25.504 843 554 17 1250 2085 136 911 1.60E-29 132 PMFBP_RAT reviewed Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) (Outer dense fiber protein 3) Pmfbp1 Odf3 Rattus norvegicus (Rat) 971 cytoskeleton organization [GO:0007010] GO:0001520; GO:0007010 0 0 0 0 A7YY35 CHOYP_LOC100376186.7.7 m.66010 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 1.61E-19 98.6 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; B2RPU2 CHOYP_PLHD1.1.1 m.23740 sp PLHD1_MOUSE 40.69 435 248 4 23 451 16 446 1.61E-102 319 PLHD1_MOUSE reviewed Pleckstrin homology domain-containing family D member 1 (PH domain-containing family D member 1) Plekhd1 Mus musculus (Mouse) 505 0 0 0 0 0 PF00169; B3EWZ6 CHOYP_LOC580670.4.6 m.19321 sp MLRP2_ACRMI 31.623 604 323 21 6 572 1157 1707 1.61E-67 241 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D9IQ16 CHOYP_NEMVEDRAFT_V1G218972.2.2 m.43495 sp GXN_ACRMI 28.448 232 148 7 56 274 91 317 1.61E-18 90.1 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 F4JLS1 CHOYP_LSDA.1.1 m.28040 sp LDL3_ARATH 30.4 125 86 1 5 129 979 1102 1.61E-12 68.6 LDL3_ARATH reviewed Lysine-specific histone demethylase 1 homolog 3 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 3) (Protein LSD1-like 3) LDL3 At4g16310/At4g16320 dl4185w/dl4190w FCAALL.342/ FCAALL.344 Arabidopsis thaliana (Mouse-ear cress) 1628 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0016491; GO:0016569 0 0 0 PF01593;PF04433; H2A0N4 CHOYP_BRAFLDRAFT_220356.5.6 m.38505 sp PIF_PINMG 26.316 266 164 14 367 611 275 529 1.61E-09 65.5 PIF_PINMG reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada margaritifera (Black-lipped pearl oyster) 1014 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607;PF00092; O00499 CHOYP_LOC100879890.1.1 m.4963 sp BIN1_HUMAN 30.976 594 312 13 20 528 12 592 1.61E-70 239 BIN1_HUMAN reviewed Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Box-dependent myc-interacting protein 1) (Bridging integrator 1) BIN1 AMPHL Homo sapiens (Human) 593 cell proliferation [GO:0008283]; endocytosis [GO:0006897]; lipid tube assembly [GO:0060988]; muscle cell differentiation [GO:0042692]; nucleus organization [GO:0006997]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; regulation of cell cycle arrest [GO:0071156]; regulation of endocytosis [GO:0030100]; regulation of neuron differentiation [GO:0045664]; viral process [GO:0016032] GO:0005634; GO:0005737; GO:0006897; GO:0006997; GO:0008283; GO:0015629; GO:0016020; GO:0016032; GO:0030018; GO:0030100; GO:0030315; GO:0030424; GO:0031674; GO:0033268; GO:0042692; GO:0042802; GO:0043065; GO:0043194; GO:0045664; GO:0048156; GO:0048711; GO:0051015; GO:0060987; GO:0060988; GO:0070063; GO:0071156 0 0 0 PF03114;PF14604; O14578 CHOYP_CIT.1.2 m.47708 sp CTRO_HUMAN 30.914 1378 794 35 888 2164 581 1901 1.61E-161 553 CTRO_HUMAN reviewed Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21) CIT CRIK KIAA0949 STK21 Homo sapiens (Human) 2027 cytokinesis [GO:0000910]; generation of neurons [GO:0048699]; intracellular signal transduction [GO:0035556]; mitotic nuclear division [GO:0007067]; positive regulation of cytokinesis [GO:0032467] GO:0000910; GO:0004674; GO:0005524; GO:0005829; GO:0007067; GO:0016020; GO:0030165; GO:0032467; GO:0035556; GO:0046872; GO:0048699; GO:0097110 0 0 0 PF00780;PF00169;PF00069; O35309 CHOYP_BRAFLDRAFT_75823.1.2 m.2870 sp NMI_MOUSE 44.262 61 31 1 148 205 160 220 1.61E-06 51.6 NMI_MOUSE reviewed N-myc-interactor (Nmi) (N-myc and STAT interactor) Nmi Mus musculus (Mouse) 314 interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha biosynthetic process [GO:0045355]; negative regulation of interferon-beta biosynthetic process [GO:0045358]; negative regulation of type I interferon production [GO:0032480]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003712; GO:0005654; GO:0005737; GO:0006366; GO:0032480; GO:0045355; GO:0045358; GO:0045824; GO:0060333; GO:1902524 0 0 0 PF07334;PF07292; O42101 CHOYP_FTZ-F1.1.1 m.45654 sp NR5A2_CHICK 41.776 304 146 6 1 285 209 500 1.61E-70 228 NR5A2_CHICK reviewed Nuclear receptor subfamily 5 group A member 2 (FTF/LRH-1) (OR2.0) NR5A2 Gallus gallus (Chicken) 501 "hormone-mediated signaling pathway [GO:0009755]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; tissue development [GO:0009888]; transcription, DNA-templated [GO:0006351]" GO:0000976; GO:0003682; GO:0003707; GO:0004879; GO:0006351; GO:0008270; GO:0009755; GO:0009888; GO:0045944; GO:0090575 0 0 0 PF00104;PF00105; O44252 CHOYP_NEMVEDRAFT_V1G237009.1.1 m.4803 sp ROST_DROME 22.3 287 174 7 38 315 10 256 1.61E-11 67 ROST_DROME reviewed Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) 275 myoblast fusion [GO:0007520]; skeletal muscle tissue development [GO:0007519] GO:0007519; GO:0007520; GO:0016020; GO:0016021 0 0 0 0 O75123 CHOYP_ZN383.1.1 m.13626 sp ZN623_HUMAN 36.462 277 153 9 116 383 194 456 1.61E-43 161 ZN623_HUMAN reviewed Zinc finger protein 623 ZNF623 KIAA0628 Homo sapiens (Human) 536 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; O75123 CHOYP_ZN436.3.3 m.64104 sp ZN623_HUMAN 39.812 319 183 4 186 503 145 455 1.61E-72 243 ZN623_HUMAN reviewed Zinc finger protein 623 ZNF623 KIAA0628 Homo sapiens (Human) 536 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; P00687 CHOYP_LOC587610.3.3 m.27175 sp AMY1_MOUSE 52.485 503 202 14 15 482 5 505 1.61E-161 478 AMY1_MOUSE reviewed "Alpha-amylase 1 (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase 1) (Salivary and hepatic alpha-amylase)" Amy1 Amy-1-a Amy1a Mus musculus (Mouse) 511 carbohydrate catabolic process [GO:0016052] GO:0004556; GO:0005509; GO:0005615; GO:0016052; GO:0016160; GO:0031404; GO:0070062 0 0 0 PF00128;PF02806; P16157 CHOYP_ANK2.7.8 m.61275 sp ANK1_HUMAN 25.865 549 354 14 5 514 232 766 1.61E-31 134 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17342 CHOYP_LOC100373708.1.1 m.41633 sp ANPRC_HUMAN 25.431 232 158 5 17 241 51 274 1.61E-12 69.7 ANPRC_HUMAN reviewed Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) NPR3 ANPRC C5orf23 NPRC Homo sapiens (Human) 541 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; cAMP-mediated signaling [GO:0019933]; negative regulation of smooth muscle cell proliferation [GO:0048662]; osteoclast proliferation [GO:0002158]; pancreatic juice secretion [GO:0030157]; phosphatidylinositol-mediated signaling [GO:0048015]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of urine volume [GO:0035810]; regulation of blood pressure [GO:0008217]; regulation of osteoblast proliferation [GO:0033688]; skeletal system development [GO:0001501] GO:0001501; GO:0002158; GO:0005622; GO:0005886; GO:0005887; GO:0007193; GO:0007200; GO:0008217; GO:0008528; GO:0016941; GO:0017046; GO:0019933; GO:0030157; GO:0033688; GO:0035810; GO:0042562; GO:0048015; GO:0048662; GO:0051000; GO:0070062 0 0 0 PF01094; P21941 CHOYP_LOC100639386.1.2 m.16187 sp MATN1_HUMAN 37.647 85 51 1 6 90 370 452 1.61E-10 66.2 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P26439 CHOYP_LOC100898467.1.1 m.5019 sp 3BHS2_HUMAN 36.24 367 215 9 1 355 1 360 1.61E-57 194 3BHS2_HUMAN reviewed 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II) (3-beta-HSD II) (3-beta-HSD adrenal and gonadal type) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] HSD3B2 HSDB3B Homo sapiens (Human) 372 androgen biosynthetic process [GO:0006702]; glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; steroid biosynthetic process [GO:0006694] GO:0003854; GO:0004769; GO:0005743; GO:0005758; GO:0005783; GO:0005789; GO:0006694; GO:0006702; GO:0006704; GO:0006705; GO:0016021; GO:0030868; GO:0031966 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF01073; P27085 CHOYP_RS26.4.15 m.19421 sp RS26_OCTVU 86.087 115 14 1 14 126 1 115 1.61E-68 205 RS26_OCTVU reviewed 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) 127 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01283; P29294 CHOYP_ISCW_ISCW020494.1.1 m.38868 sp MYLK_RABIT 51.829 328 148 3 33 360 673 990 1.61E-113 359 MYLK_RABIT reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK Oryctolagus cuniculus (Rabbit) 1147 0 GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0030027; GO:0032154; GO:0046872 0 0 0 PF00041;PF07679;PF00069; Q12809 CHOYP_KCNH2.1.1 m.56036 sp KCNH2_HUMAN 36.579 380 170 12 1 313 1 376 1.61E-55 197 KCNH2_HUMAN reviewed Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1) KCNH2 ERG ERG1 HERG Homo sapiens (Human) 1159 cardiac conduction [GO:0061337]; cardiac muscle contraction [GO:0060048]; cellular response to drug [GO:0035690]; membrane depolarization during action potential [GO:0086010]; membrane repolarization during action potential [GO:0086011]; membrane repolarization during cardiac muscle cell action potential [GO:0086013]; membrane repolarization during ventricular cardiac muscle cell action potential [GO:0098915]; negative regulation of potassium ion export [GO:1902303]; negative regulation of potassium ion transmembrane transport [GO:1901380]; positive regulation of potassium ion transmembrane transport [GO:1901381]; potassium ion export [GO:0071435]; potassium ion export across plasma membrane [GO:0097623]; potassium ion homeostasis [GO:0055075]; potassium ion transmembrane transport [GO:0071805]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of heart rate by hormone [GO:0003064]; regulation of membrane potential [GO:0042391]; regulation of membrane repolarization [GO:0060306]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0000155; GO:0003064; GO:0005242; GO:0005249; GO:0005251; GO:0005886; GO:0008076; GO:0009986; GO:0031625; GO:0035690; GO:0042391; GO:0042802; GO:0042803; GO:0048471; GO:0055075; GO:0055131; GO:0060048; GO:0060306; GO:0060307; GO:0061337; GO:0071435; GO:0071805; GO:0086005; GO:0086008; GO:0086010; GO:0086011; GO:0086013; GO:0086091; GO:0097110; GO:0097623; GO:0098915; GO:1901379; GO:1901380; GO:1901381; GO:1902282; GO:1902303 0 0 0 PF00027;PF00520;PF13426; Q13351 CHOYP_LOC100313642.1.1 m.31840 sp KLF1_HUMAN 79.091 110 21 1 280 389 255 362 1.61E-59 199 KLF1_HUMAN reviewed Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF) KLF1 EKLF Homo sapiens (Human) 362 "cellular response to peptide [GO:1901653]; erythrocyte differentiation [GO:0030218]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000790; GO:0000987; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0030218; GO:0044212; GO:0045893; GO:0046872; GO:1901653 0 0 0 PF16832;PF16833;PF00096; Q29121 CHOYP_GALT1.1.1 m.33853 sp GALT1_PIG 38.095 504 284 12 104 593 59 548 1.61E-107 337 GALT1_PIG reviewed Polypeptide N-acetylgalactosaminyltransferase 1 (EC 2.4.1.41) (Polypeptide GalNAc transferase 1) (GalNAc-T1) (pp-GaNTase 1) (Protein-UDP acetylgalactosaminyltransferase 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 1 soluble form] GALNT1 Sus scrofa (Pig) 559 protein O-linked glycosylation [GO:0006493] GO:0004653; GO:0005576; GO:0006493; GO:0016021; GO:0030145; GO:0030246; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q2KHU0 CHOYP_SERB.1.1 m.7242 sp SERB_BOVIN 57.534 219 93 0 7 225 6 224 1.61E-94 278 SERB_BOVIN reviewed Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase) PSPH Bos taurus (Bovine) 225 L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563] GO:0000287; GO:0004647; GO:0005509; GO:0005737; GO:0006563; GO:0006564 PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3. 0 0 0 Q3KR53 CHOYP_GPBP1.1.1 m.51090 sp GPBL1_RAT 28.03 528 241 26 8 453 3 473 1.61E-16 85.1 GPBL1_RAT reviewed Vasculin-like protein 1 (GC-rich promoter-binding protein 1-like 1) Gpbp1l1 Rattus norvegicus (Rat) 475 "positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0045893 0 0 0 PF15337; Q3TI53 CHOYP_contig_029494 m.33476 sp SCHI1_MOUSE 40 270 113 9 326 557 217 475 1.61E-37 148 SCHI1_MOUSE reviewed Schwannomin-interacting protein 1 (SCHIP-1) Schip1 Mus musculus (Mouse) 484 estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; fibroblast migration [GO:0010761]; kidney development [GO:0001822]; luteinization [GO:0001553]; nitrogen compound metabolic process [GO:0006807]; palate development [GO:0060021]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745] GO:0001553; GO:0001822; GO:0005737; GO:0006807; GO:0008210; GO:0008585; GO:0009791; GO:0010761; GO:0042802; GO:0042803; GO:0048008; GO:0048705; GO:0048745; GO:0060021; GO:0060325 0 0 0 PF10148; Q4PMB3 CHOYP_RS4.10.11 m.60432 sp RS4_IXOSC 54.808 104 30 3 2 93 162 260 1.61E-24 107 RS4_IXOSC reviewed 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) 262 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q4R5T4 CHOYP_LOC581813.1.1 m.19289 sp RNF32_MACFA 43.521 409 168 6 18 422 11 360 1.61E-105 319 RNF32_MACFA reviewed RING finger protein 32 RNF32 QtsA-17885 QtsA-21017 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 362 0 GO:0005737; GO:0008270 0 0 0 PF00612;PF13639;PF13445; Q4UMH6 CHOYP_V228.1.1 m.31993 sp Y381_RICFE 29.741 232 153 3 55 286 898 1119 1.61E-20 97.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q57951 CHOYP_NEMVEDRAFT_V1G246422.1.1 m.1312 sp Y531_METJA 28.571 154 91 4 10 156 25 166 1.61E-09 57 Y531_METJA reviewed Universal stress protein MJ0531 (USP MJ0531) MJ0531 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 170 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q5ND28 CHOYP_SREC.4.4 m.60221 sp SREC_MOUSE 35.521 259 134 10 177 419 145 386 1.61E-29 125 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5UQ50 CHOYP_CBG22657.1.2 m.28798 sp COLL6_MIMIV 36.842 266 130 9 229 460 479 740 1.61E-07 57.8 COLL6_MIMIV reviewed Collagen-like protein 6 MIMI_L668 Acanthamoeba polyphaga mimivirus (APMV) 1387 0 GO:0019012 0 0 0 PF01391; Q64459 CHOYP_CP3AB.4.4 m.47872 sp CP3AB_MOUSE 41.245 514 282 7 1 511 1 497 1.61E-136 407 CP3AB_MOUSE reviewed Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (Cytochrome P-450IIIAM1) (Cytochrome P-450UT) Cyp3a11 Cyp3a-11 Mus musculus (Mouse) 504 0 GO:0004497; GO:0005506; GO:0005789; GO:0016491; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q6AZL2 CHOYP_BRCA2.1.2 m.17660 sp PAF15_XENTR 60 80 27 2 17 91 19 98 1.61E-21 85.5 PAF15_XENTR reviewed PCNA-associated factor (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) paf Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 125 cellular response to DNA damage stimulus [GO:0006974]; centrosome organization [GO:0051297]; DNA replication [GO:0006260]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] GO:0003682; GO:0005634; GO:0006260; GO:0006974; GO:0009411; GO:0019985; GO:0048471; GO:0051297; GO:0051726 0 0 0 PF15715; Q6P5D8 CHOYP_BRAFLDRAFT_285500.1.1 m.58290 sp SMHD1_MOUSE 48.466 163 77 2 1 157 1830 1991 1.61E-44 161 SMHD1_MOUSE reviewed Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Smchd1 Kiaa0650 Mus musculus (Mouse) 2007 chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; inactivation of X chromosome by DNA methylation [GO:0060821] GO:0000781; GO:0001740; GO:0005524; GO:0009048; GO:0051276; GO:0060821 0 0 0 PF06470; Q6TFL4 CHOYP_KLH24.3.6 m.40057 sp KLH24_HUMAN 23.293 498 308 16 4 449 76 551 1.61E-16 85.9 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q6ZRF8 CHOYP_LOC100374981.16.16 m.66900 sp RN207_HUMAN 23.045 243 164 9 16 247 103 333 1.61E-08 60.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZUJ8 CHOYP_BCAP.2.2 m.41601 sp BCAP_HUMAN 25.874 429 247 15 4 376 12 425 1.61E-23 110 BCAP_HUMAN reviewed Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Homo sapiens (Human) 805 negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] GO:0005829; GO:0005886; GO:0014068; GO:0016020; GO:0034122; GO:0034123; GO:0034134; GO:0034142; GO:0034154; GO:0034162; GO:0036312; GO:0050727 0 0 0 PF14545; Q86X02 CHOYP_CDR2L.1.1 m.22562 sp CDR2L_HUMAN 30.454 463 268 14 1 425 7 453 1.61E-38 148 CDR2L_HUMAN reviewed Cerebellar degeneration-related protein 2-like (Paraneoplastic 62 kDa antigen) CDR2L HUMPPA Homo sapiens (Human) 465 0 0 0 0 0 0 Q8BS40 CHOYP_LOC100369198.1.1 m.11037 sp CPTP_MOUSE 35.814 215 133 2 6 215 2 216 1.61E-45 153 CPTP_MOUSE reviewed Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP) Cptp Gltpd1 Mus musculus (Mouse) 216 ceramide 1-phosphate transport [GO:1902389] GO:0005543; GO:0005548; GO:0005634; GO:0005640; GO:0005730; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0017089; GO:0051861; GO:1902387; GO:1902388; GO:1902389 0 0 0 PF08718; Q8ISN9 CHOYP_RS25.9.11 m.41033 sp RS25_BRABE 76.136 88 21 0 20 107 28 115 1.61E-35 120 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8IYA7 CHOYP_LOC100357336.1.1 m.23581 sp MKX_HUMAN 40.064 312 151 7 6 314 42 320 1.61E-56 189 MKX_HUMAN reviewed Homeobox protein Mohawk MKX C10orf48 IRXL1 Homo sapiens (Human) 352 "muscle organ development [GO:0007517]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0007517; GO:0043565 0 0 0 PF05920; Q8K0U4 CHOYP_HS12A.30.33 m.61960 sp HS12A_MOUSE 31.479 629 363 12 31 602 56 673 1.61E-98 317 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K4G1 CHOYP_LOC100635497.3.3 m.47367 sp LTBP4_MOUSE 36.062 452 231 27 42 467 610 1029 1.61E-44 176 LTBP4_MOUSE reviewed Latent-transforming growth factor beta-binding protein 4 (LTBP-4) Ltbp4 Mus musculus (Mouse) 1666 hormone secretion [GO:0046879]; regulation of proteolysis [GO:0030162]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005509; GO:0005578; GO:0005615; GO:0007179; GO:0030162; GO:0031012; GO:0046879; GO:0050431; GO:0070062 0 0 0 PF07645;PF00683; Q8TBF8 CHOYP_BRAFLDRAFT_98567.1.2 m.57259 sp FA81A_HUMAN 32.527 372 227 7 27 392 10 363 1.61E-50 177 FA81A_HUMAN reviewed Protein FAM81A FAM81A Homo sapiens (Human) 368 0 0 0 0 0 0 Q8TDB6 CHOYP_LOC100370200.4.5 m.53661 sp DTX3L_HUMAN 52.151 186 87 2 314 499 556 739 1.61E-56 204 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8TDX6 CHOYP_LOC659298.1.1 m.52907 sp CGAT1_HUMAN 41.483 499 268 8 15 496 26 517 1.61E-138 412 CGAT1_HUMAN reviewed "Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1)" CSGALNACT1 CHGN GALNACT1 UNQ656/PRO1287 Homo sapiens (Human) 532 "anatomical structure morphogenesis [GO:0009653]; cartilage development [GO:0051216]; cell proliferation [GO:0008283]; cell recognition [GO:0008037]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0050653]; dermatan sulfate proteoglycan biosynthetic process [GO:0050651]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; heparin biosynthetic process [GO:0030210]; nervous system development [GO:0007399]; proteoglycan biosynthetic process [GO:0030166]; UDP-glucuronate metabolic process [GO:0046398]; UDP-N-acetylgalactosamine metabolic process [GO:0019276]" GO:0000139; GO:0001958; GO:0005622; GO:0007399; GO:0008037; GO:0008283; GO:0008376; GO:0008955; GO:0009653; GO:0015014; GO:0015020; GO:0019276; GO:0030166; GO:0030173; GO:0030198; GO:0030206; GO:0030210; GO:0032580; GO:0046398; GO:0046872; GO:0047237; GO:0047238; GO:0050650; GO:0050651; GO:0050653; GO:0051216 0 0 0 PF05679; Q8WVZ9 CHOYP_BACH1.8.17 m.18006 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 1.61E-08 61.6 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q96JI7 CHOYP_SPTCS.1.1 m.35810 sp SPTCS_HUMAN 22.828 495 339 10 7 479 1535 2008 1.61E-23 108 SPTCS_HUMAN reviewed Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) 2443 axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; synaptic vesicle transport [GO:0048489] GO:0005730; GO:0005737; GO:0005765; GO:0005829; GO:0005886; GO:0007268; GO:0008088; GO:0030424; GO:0030425; GO:0031410; GO:0045202; GO:0048489; GO:0048675; GO:0070062 0 0 0 PF14649; Q9CZJ2 CHOYP_BRAFLDRAFT_240194.1.2 m.34961 sp HS12B_MOUSE 32.51 486 273 10 10 446 61 540 1.61E-79 263 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9IAL1 CHOYP_VSX2.1.1 m.9648 sp VSX2_CHICK 61.878 181 54 2 184 349 172 352 1.61E-69 226 VSX2_CHICK reviewed Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) VSX2 CHX10 Gallus gallus (Chicken) 377 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; response to stimulus [GO:0050896]; transcription, DNA-templated [GO:0006351]; visual perception [GO:0007601]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0007601; GO:0043565; GO:0050896 0 0 0 PF00046;PF03826; Q9NUA8 CHOYP_LOC658322.1.1 m.9324 sp ZBT40_HUMAN 21.22 410 213 12 867 1224 807 1158 1.61E-06 56.6 ZBT40_HUMAN reviewed Zinc finger and BTB domain-containing protein 40 ZBTB40 KIAA0478 Homo sapiens (Human) 1239 "bone mineralization [GO:0030282]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0006974; GO:0030282; GO:0046872 0 0 0 PF00651; Q9P0U4 CHOYP_LOC590665.1.1 m.25315 sp CXXC1_HUMAN 60.145 276 104 3 283 554 374 647 1.61E-121 375 CXXC1_HUMAN reviewed CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) CXXC1 CFP1 CGBP PCCX1 PHF18 Homo sapiens (Human) 656 "histone H3-K4 methylation [GO:0051568]; IRE1-mediated unfolded protein response [GO:0036498]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000987; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0016363; GO:0016607; GO:0035097; GO:0036498; GO:0045322; GO:0045893; GO:0048188; GO:0051568 0 0 0 PF00628;PF12269;PF02008; Q9VCA8 CHOYP_LOC754047.1.3 m.38989 sp ANKHM_DROME 31.144 411 237 10 10 377 568 975 1.61E-40 157 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9XWD6 CHOYP_LOC100182955.1.2 m.32287 sp CED1_CAEEL 39.64 111 63 2 45 153 349 457 1.61E-14 75.5 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; A4IF63 CHOYP_BRAFLDRAFT_93988.1.3 m.663 sp TRIM2_BOVIN 30.189 106 70 3 20 122 627 731 1.62E-06 49.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8SMG2 CHOYP_LOC754355.1.1 m.66745 sp TEX43_BOVIN 27.068 133 91 2 1 130 1 130 1.62E-08 52.8 TEX43_BOVIN reviewed Testis-expressed sequence 43 protein TEX43 Bos taurus (Bovine) 133 0 0 0 0 0 PF14983; B0FYY4 CHOYP_BRAFLDRAFT_236087.1.1 m.44963 sp ITB1_SHEEP 39.175 194 106 3 8 191 607 798 1.62E-38 143 ITB1_SHEEP reviewed Integrin beta-1 (Fibronectin receptor subunit beta) (Integrin subunit beta-1) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Ovis aries (Sheep) 798 cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; receptor internalization [GO:0031623]; regulation of collagen catabolic process [GO:0010710] GO:0004872; GO:0005925; GO:0007160; GO:0007229; GO:0008305; GO:0009986; GO:0010710; GO:0016020; GO:0030027; GO:0031623; GO:0032587; GO:0033627; GO:0042470; GO:0046872; GO:0046982; GO:0055037; GO:0071404; GO:0071438; GO:0090004 0 0 0 PF07974;PF08725;PF07965;PF00362; D2GXS7 CHOYP_BRAFLDRAFT_255103.11.18 m.47303 sp TRIM2_AILME 22.692 260 178 7 37 280 492 744 1.62E-09 62 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F4IYM4 CHOYP_LOC574700.1.1 m.8763 sp DEX1_ARATH 30.426 493 308 11 181 658 408 880 1.62E-66 238 DEX1_ARATH reviewed Protein DEFECTIVE IN EXINE FORMATION 1 DEX1 At3g09090 MZB10.12 Arabidopsis thaliana (Mouse-ear cress) 896 cell wall organization [GO:0071555]; pollen exine formation [GO:0010584]; pollen wall assembly [GO:0010208] GO:0005509; GO:0005783; GO:0005886; GO:0010208; GO:0010584; GO:0016020; GO:0016021; GO:0071555 0 0 0 PF01839; O43301 CHOYP_HS12A.11.33 m.39341 sp HS12A_HUMAN 31.356 590 345 15 1094 1627 50 635 1.62E-75 269 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O43301 CHOYP_HS12A.23.33 m.59988 sp HS12A_HUMAN 31.649 376 203 12 12 334 148 522 1.62E-53 191 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O45782 CHOYP_LOC100178217.2.2 m.61741 sp ARD17_CAEEL 33.856 319 177 14 1 298 1 306 1.62E-34 134 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; O57592 CHOYP_LOC100707299.1.1 m.15097 sp RL7A_TAKRU 61.616 99 38 0 3 101 101 199 1.62E-35 125 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O70251 CHOYP_BRAFLDRAFT_115464.1.2 m.22827 sp EF1B_MOUSE 77.419 62 14 0 30 91 1 62 1.62E-27 102 EF1B_MOUSE reviewed Elongation factor 1-beta (EF-1-beta) Eef1b Eef1b2 Mus musculus (Mouse) 225 0 GO:0003746; GO:0005737; GO:0005783; GO:0005853 0 0 cd00292; PF10587;PF00736; O96064 CHOYP_MYSP.2.9 m.1761 sp MYSP_MYTGA 54.286 105 44 2 71 174 376 477 1.62E-20 91.3 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P05099 CHOYP_MATN1.1.5 m.29893 sp MATN1_CHICK 26.757 441 248 14 38 429 35 449 1.62E-38 148 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P09487 CHOYP_PPBT.4.4 m.62904 sp PPBT_BOVIN 50.622 482 218 9 20 494 29 497 1.62E-160 469 PPBT_BOVIN reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) 524 biomineral tissue development [GO:0031214]; cellular response to organic cyclic compound [GO:0071407]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; osteoblast differentiation [GO:0001649]; response to antibiotic [GO:0046677]; response to vitamin D [GO:0033280] GO:0001649; GO:0001958; GO:0003006; GO:0004035; GO:0005578; GO:0005886; GO:0016462; GO:0031214; GO:0031225; GO:0033280; GO:0046677; GO:0046872; GO:0065010; GO:0070062; GO:0071407 0 0 0 PF00245; P12391 CHOYP_CHRNB3.1.1 m.26792 sp ACHB3_RAT 27.586 348 237 5 1 335 1 346 1.62E-37 144 ACHB3_RAT reviewed Neuronal acetylcholine receptor subunit beta-3 Chrnb3 Acrb3 Rattus norvegicus (Rat) 464 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0035094; GO:0042166; GO:0043005; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; P18101 CHOYP_LOC100695843.3.4 m.29978 sp RL40_DROME 69.318 88 27 0 13 100 38 125 1.62E-37 125 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; P19199 CHOYP_LOC100566709.1.1 m.18399 sp POL_COYMV 25.413 303 180 14 18 300 1561 1837 1.62E-06 54.3 POL_COYMV reviewed Polyprotein P3 [Includes: Putative movement protein (MP); Capsid protein (Coat protein) (CP); Protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] 0 Commelina yellow mottle virus (CoYMV) 1886 "transport of virus in host, cell to cell [GO:0046740]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]" GO:0003676; GO:0003964; GO:0004190; GO:0004523; GO:0008270; GO:0046718; GO:0046740; GO:0075732 0 0 0 PF00077;PF00078; P23508 CHOYP_LOC581024.1.1 m.31099 sp CRCM_HUMAN 46.154 156 67 3 37 176 19 173 1.62E-26 108 CRCM_HUMAN reviewed Colorectal mutant cancer protein (Protein MCC) MCC Homo sapiens (Human) 829 establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] GO:0004872; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007165; GO:0010633; GO:0016055; GO:0030027; GO:0045184; GO:0050680; GO:0090090 0 0 0 PF10506; P24774 CHOYP_CYTB.2.6 m.11380 sp RET4A_ONCMY 84.848 66 10 0 50 115 50 115 1.62E-37 127 RET4A_ONCMY reviewed Retinol-binding protein 4-A (Plasma retinol-binding protein 1) (PRBP-1) (Plasma retinol-binding protein II) (PRBP-I) rbp4a Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 176 0 GO:0005215; GO:0005615; GO:0019841; GO:0060417 0 0 0 PF00061; P28606 CHOYP_LOC101155869.1.1 m.7291 sp Y1628_SYNP2 50.167 299 149 0 52 350 2 300 1.62E-105 314 Y1628_SYNP2 reviewed Uncharacterized protein SYNPCC7002_A1628 SYNPCC7002_A1628 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) 300 0 GO:0016787 0 0 0 PF00850; P52800 CHOYP_LOC100161694.1.1 m.62833 sp EFNB2_MOUSE 30.698 215 128 8 18 225 11 211 1.62E-20 93.2 EFNB2_MOUSE reviewed Ephrin-B2 (ELF-2) (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) Efnb2 Elf2 Epl5 Eplg5 Htkl Lerk5 Mus musculus (Mouse) 336 axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; lymph vessel development [GO:0001945]; negative regulation of keratinocyte proliferation [GO:0010839]; nephric duct morphogenesis [GO:0072178]; organ morphogenesis [GO:0009887]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; regulation of chemotaxis [GO:0050920]; T cell costimulation [GO:0031295]; venous blood vessel morphogenesis [GO:0048845] GO:0001945; GO:0002042; GO:0005102; GO:0005886; GO:0005925; GO:0007155; GO:0007411; GO:0009887; GO:0010839; GO:0016021; GO:0016477; GO:0031295; GO:0046875; GO:0048013; GO:0048514; GO:0048845; GO:0050920; GO:0072178; GO:1903849; GO:2000727 0 0 0 PF00812; P82197 CHOYP_PDXK.1.1 m.14904 sp PDXK_SHEEP 56.478 301 118 6 37 324 3 303 1.62E-112 332 PDXK_SHEEP reviewed Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) PDXK PKH Ovis aries (Sheep) 312 pyridoxal 5'-phosphate salvage [GO:0009443] GO:0005524; GO:0005737; GO:0008478; GO:0009443; GO:0046872 0 0 cd01173; PF08543; Q148V8 CHOYP_AGAP_AGAP007349.4.5 m.13124 sp FA83H_MOUSE 42.169 83 48 0 1 83 866 948 1.62E-07 51.2 FA83H_MOUSE reviewed Protein FAM83H Fam83h Mus musculus (Mouse) 1209 biomineral tissue development [GO:0031214]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of cell migration [GO:0030335]; protein localization to cytoskeleton [GO:0044380] GO:0005737; GO:0019901; GO:0030335; GO:0031214; GO:0044380; GO:0045095; GO:0045104; GO:1990254 0 0 0 PF07894; Q19QU3 CHOYP_ZRAB2.1.1 m.4611 sp ZRAB2_PIG 68.548 124 36 3 22 144 6 127 1.62E-54 182 ZRAB2_PIG reviewed Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) ZRANB2 ZNF265 Sus scrofa (Pig) 328 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0006397; GO:0008270; GO:0008380; GO:0044822 0 0 0 PF00641; Q27433 CHOYP_LOC100313653.1.1 m.61188 sp MEC2_CAEEL 67.537 268 87 0 3 270 102 369 1.62E-127 373 MEC2_CAEEL reviewed Mechanosensory protein 2 mec-2 F14D12.4 Caenorhabditis elegans 481 mechanosensory behavior [GO:0007638]; response to mechanical stimulus [GO:0009612] GO:0007638; GO:0009612; GO:0015485; GO:0016021; GO:0032589; GO:0043005 0 0 0 PF01145; Q29116 CHOYP_ANGP4.7.7 m.64085 sp TENA_PIG 41.593 226 118 5 351 566 1512 1733 1.62E-50 191 TENA_PIG reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) 1746 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041; Q2KI00 CHOYP_LOC100892914.1.1 m.53491 sp F107B_BOVIN 34.259 108 66 2 75 180 14 118 1.62E-06 48.9 F107B_BOVIN reviewed Protein FAM107B FAM107B Bos taurus (Bovine) 131 0 0 0 0 0 PF06625; Q3MHV6 CHOYP_SLAI2.1.2 m.8777 sp SLAI2_BOVIN 28.067 595 285 27 1 465 1 582 1.62E-20 97.8 SLAI2_BOVIN reviewed SLAIN motif-containing protein 2 SLAIN2 Bos taurus (Bovine) 582 cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116] GO:0005737; GO:0007020; GO:0015630; GO:0031116; GO:0031122 0 0 0 PF15301; Q3SX11 CHOYP_BRAFLDRAFT_60200.3.3 m.37425 sp NSA2_BOVIN 83.077 260 44 0 1 260 1 260 1.62E-165 461 NSA2_BOVIN reviewed Ribosome biogenesis protein NSA2 homolog (TGF-beta-inducible nuclear protein 1) NSA2 TINP1 Bos taurus (Bovine) 260 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0005730; GO:0030687; GO:0044822 0 0 0 PF01201; Q4UMH6 CHOYP_LOC755594.4.6 m.53187 sp Y381_RICFE 27.108 332 219 8 985 1313 665 976 1.62E-24 115 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5E9E1 CHOYP_LDB3.1.1 m.371 sp PDLI1_BOVIN 46.914 81 39 2 4 83 6 83 1.62E-13 76.3 PDLI1_BOVIN reviewed PDZ and LIM domain protein 1 (Elfin) PDLIM1 Bos taurus (Bovine) 328 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003713; GO:0005667; GO:0005737; GO:0005856; GO:0006355; GO:0008270 0 0 0 PF15936;PF00412;PF00595; Q5RBX2 CHOYP_CADM2.2.2 m.50429 sp BET1L_PONAB 56.383 94 41 0 5 98 14 107 1.62E-32 112 BET1L_PONAB reviewed BET1-like protein BET1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 111 protein transport [GO:0015031] GO:0000139; GO:0015031; GO:0016021 0 0 0 0 Q5RHP9 CHOYP_LOC100709948.1.1 m.9245 sp ERIC3_HUMAN 35.177 452 218 10 1 432 1 397 1.62E-67 256 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q5S007 CHOYP_LOC581823.1.1 m.13656 sp LRRK2_HUMAN 28.857 551 337 15 1 520 1996 2522 1.62E-61 224 LRRK2_HUMAN reviewed Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin) LRRK2 PARK8 Homo sapiens (Human) 2527 "activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; canonical Wnt signaling pathway [GO:0060070]; cellular protein localization [GO:0034613]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of protein processing involved in protein targeting to mitochondrion [GO:1903217]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron death [GO:0070997]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; protein autophosphorylation [GO:0046777]; protein localization to mitochondrion [GO:0070585]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of calcium-mediated signaling [GO:0050848]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of mitochondrial fission [GO:0090140]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron death [GO:1901214]; regulation of neuron maturation [GO:0014041]; regulation of protein kinase A signaling [GO:0010738]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; small GTPase mediated signal transduction [GO:0007264]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]" GO:0000149; GO:0000165; GO:0000186; GO:0000187; GO:0001933; GO:0001934; GO:0001948; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004708; GO:0005096; GO:0005524; GO:0005525; GO:0005615; GO:0005622; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005901; GO:0005902; GO:0006468; GO:0006897; GO:0006914; GO:0006979; GO:0007005; GO:0007030; GO:0007040; GO:0007264; GO:0007528; GO:0008017; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010738; GO:0010955; GO:0014041; GO:0015631; GO:0016234; GO:0016242; GO:0016301; GO:0016310; GO:0017048; GO:0017075; GO:0018105; GO:0018107; GO:0019722; GO:0021772; GO:0022028; GO:0030054; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030529; GO:0030672; GO:0031398; GO:0031410; GO:0031966; GO:0032091; GO:0032092; GO:0032436; GO:0032473; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034613; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0035751; GO:0036479; GO:0039706; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0043406; GO:0044325; GO:0044753; GO:0044754; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0050848; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060070; GO:0060079; GO:0060159; GO:0060161; GO:0060828; GO:0061001; GO:0070062; GO:0070585; GO:0070997; GO:0071287; GO:0072593; GO:0090140; GO:0090263; GO:0090394; GO:0097487; GO:0098794; GO:1901214; GO:1901215; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902823; GO:1902902; GO:1903125; GO:1903206; GO:1903215; GO:1903217; GO:1903351; GO:1904713; GO:1904887; GO:1905279; GO:1990909; GO:2000172; GO:2000300 0 0 0 PF16095;PF12799;PF13855;PF00069;PF08477; Q5U2W4 CHOYP_NEMVEDRAFT_V1G200332.1.1 m.19402 sp CENPN_RAT 23.343 347 251 7 4 346 5 340 1.62E-26 110 CENPN_RAT reviewed Centromere protein N (CENP-N) Cenpn Rattus norvegicus (Rat) 340 centromere complex assembly [GO:0034508]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005634; GO:0007059; GO:0007067; GO:0034508 0 0 0 PF05238; Q5XNR9 CHOYP_IL6ST.1.1 m.7685 sp LIFR_CANLF 24.221 578 349 33 115 664 326 842 1.62E-13 79 LIFR_CANLF reviewed Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) LIFR Canis lupus familiaris (Dog) (Canis familiaris) 1097 positive regulation of cell proliferation [GO:0008284] GO:0004923; GO:0004924; GO:0005886; GO:0008284; GO:0016021; GO:0043235; GO:0070062 0 0 0 PF00041; Q63HN8 CHOYP_BRAFLDRAFT_106560.3.14 m.5040 sp RN213_HUMAN 22.111 398 247 14 440 811 4760 5120 1.62E-08 62.8 RN213_HUMAN reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) 5207 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:21799892}. 0 0 PF00097; Q640Z9 CHOYP_LRC14.1.1 m.11486 sp LRC14_XENLA 25.054 467 305 12 34 473 3 451 1.62E-21 101 LRC14_XENLA reviewed Leucine-rich repeat-containing protein 14 lrrc14 Xenopus laevis (African clawed frog) 509 0 0 0 0 0 PF13516; Q86SZ2 CHOYP_LOC594183.1.1 m.22615 sp TPC6B_HUMAN 66.667 156 50 1 5 158 1 156 1.62E-77 230 TPC6B_HUMAN reviewed Trafficking protein particle complex subunit 6B TRAPPC6B Homo sapiens (Human) 158 COPII vesicle coating [GO:0048208] GO:0000139; GO:0005783; GO:0005829; GO:0048208 0 0 0 PF04051; Q8IYB1 CHOYP_CPIPJ_CPIJ007154.1.1 m.23769 sp M21D2_HUMAN 27.5 160 105 7 129 286 236 386 1.62E-08 60.8 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8N2R8 CHOYP_LOC100883420.1.1 m.61904 sp FA43A_HUMAN 40.566 212 109 7 2 203 52 256 1.62E-40 150 FA43A_HUMAN reviewed Protein FAM43A FAM43A PP7298 Homo sapiens (Human) 423 0 0 0 0 0 PF14719; Q91VP7 CHOYP_TM101.1.1 m.16703 sp TM101_MOUSE 30.159 252 166 4 5 247 4 254 1.62E-32 122 TM101_MOUSE reviewed Transmembrane protein 101 Tmem101 Mus musculus (Mouse) 257 positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0016021; GO:0043123 0 0 0 PF15111; Q92643 CHOYP_PHUM_PHUM387860.1.1 m.56749 sp GPI8_HUMAN 68.77 317 96 1 305 618 35 351 1.62E-165 481 GPI8_HUMAN reviewed GPI-anchor transamidase (GPI transamidase) (EC 3.-.-.-) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K) PIGK GPI8 Homo sapiens (Human) 395 attachment of GPI anchor to protein [GO:0016255]; protein localization to cell surface [GO:0034394] GO:0003756; GO:0003923; GO:0005789; GO:0008234; GO:0016020; GO:0016255; GO:0030176; GO:0034394; GO:0042765 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF01650; Q96DB5 CHOYP_LOC100074304.1.1 m.27870 sp RMD1_HUMAN 52.402 229 108 1 78 305 86 314 1.62E-82 254 RMD1_HUMAN reviewed Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B) RMDN1 FAM82B CGI-90 Homo sapiens (Human) 314 0 GO:0000922; GO:0005739; GO:0005874 0 0 0 0 Q96II8 CHOYP_LRCH3.3.4 m.42230 sp LRCH3_HUMAN 54.661 236 106 1 12 247 44 278 1.62E-72 259 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q9ESN6 CHOYP_BRAFLDRAFT_82426.1.20 m.8067 sp TRIM2_MOUSE 25.909 220 139 6 346 554 536 742 1.62E-09 64.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9FFU6 CHOYP_NEMVEDRAFT_V1G243101.2.2 m.53777 sp B561A_ARATH 34.416 154 92 3 346 498 670 815 1.62E-18 93.2 B561A_ARATH reviewed "Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830 (Protein b561A.tha1)" At5g54830 MBG8_9 Arabidopsis thaliana (Mouse-ear cress) 907 oxidation-reduction process [GO:0055114] GO:0005768; GO:0005794; GO:0005802; GO:0016021; GO:0046872; GO:0055114 0 0 0 PF03188;PF10517;PF03351; Q9JHG6 CHOYP_LOC100902369.1.2 m.13449 sp RCAN1_MOUSE 47.959 196 89 2 33 219 2 193 1.62E-58 186 RCAN1_MOUSE reviewed Calcipressin-1 (Down syndrome critical region protein 1 homolog) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) Rcan1 Dscr1 Mus musculus (Mouse) 198 calcineurin-NFAT signaling cascade [GO:0033173]; locomotion involved in locomotory behavior [GO:0031987]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; regulation of phosphoprotein phosphatase activity [GO:0043666]; response to ischemia [GO:0002931]; response to oxidative stress [GO:0006979]; short-term memory [GO:0007614]; skeletal muscle fiber development [GO:0048741] GO:0000166; GO:0002931; GO:0005634; GO:0005737; GO:0006979; GO:0007614; GO:0008597; GO:0031987; GO:0033173; GO:0043666; GO:0048741; GO:0070884 0 0 0 PF04847; Q9N0C7 CHOYP_ZGC_174877.1.3 m.4382 sp EPDR1_MACFA 29.348 184 123 4 11 190 30 210 1.62E-24 98.6 EPDR1_MACFA reviewed Mammalian ependymin-related protein 1 (MERP-1) EPDR1 MERP1 QccE-12983 QmoA-12340 QmoA-13475 QtrA-11871 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00811; Q9NUV9 CHOYP_LOC100694918.1.1 m.5159 sp GIMA4_HUMAN 52.83 106 50 0 56 161 28 133 1.62E-32 120 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9NX74 CHOYP_ARP6.1.1 m.17919 sp DUS2L_HUMAN 49.443 449 212 3 32 473 10 450 1.62E-156 458 DUS2L_HUMAN reviewed tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.-) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) DUS2 DUS2L Homo sapiens (Human) 493 negative regulation of cell death [GO:0060548] GO:0003725; GO:0004860; GO:0005737; GO:0005739; GO:0005783; GO:0005829; GO:0017150; GO:0050660; GO:0060548 0 0 0 PF00035;PF01207; Q9NX74 CHOYP_LOC581221.1.1 m.9987 sp DUS2L_HUMAN 47.107 363 177 3 1 356 96 450 1.62E-114 347 DUS2L_HUMAN reviewed tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.-) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) DUS2 DUS2L Homo sapiens (Human) 493 negative regulation of cell death [GO:0060548] GO:0003725; GO:0004860; GO:0005737; GO:0005739; GO:0005783; GO:0005829; GO:0017150; GO:0050660; GO:0060548 0 0 0 PF00035;PF01207; Q9P243 CHOYP_LOC100378691.1.2 m.2038 sp ZFAT_HUMAN 39.574 235 133 5 1 233 276 503 1.62E-44 165 ZFAT_HUMAN reviewed Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) ZFAT KIAA1485 ZFAT1 ZNF406 Homo sapiens (Human) 1243 hematopoietic progenitor cell differentiation [GO:0002244]; multicellular organism development [GO:0007275]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; spongiotrophoblast layer development [GO:0060712] GO:0000977; GO:0001077; GO:0002244; GO:0003700; GO:0005634; GO:0005829; GO:0007275; GO:0045944; GO:0046872; GO:0060712 0 0 0 0 Q9VN14 CHOYP_LOC100902807.4.4 m.59166 sp CONT_DROME 29.476 1106 675 26 153 1224 323 1357 1.62E-139 462 CONT_DROME reviewed Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) 1390 axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nerve maturation [GO:0021682]; septate junction assembly [GO:0019991] GO:0005886; GO:0005918; GO:0008366; GO:0019991; GO:0021682; GO:0031225; GO:0045197; GO:0060857; GO:0061343 0 0 0 PF00041;PF00047;PF00059; A4Q9F4 CHOYP_TTL11.1.1 m.51012 sp TTL11_MOUSE 37.54 618 319 11 17 624 122 682 1.63E-135 416 TTL11_MOUSE reviewed Tubulin polyglutamylase TTLL11 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 11) Ttll11 Mus musculus (Mouse) 727 microtubule severing [GO:0051013]; protein polyglutamylation [GO:0018095] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0016874; GO:0018095; GO:0051013 0 0 0 PF03133; A4QP81 CHOYP_LOC100168620.1.4 m.8866 sp FRRS1_DANRE 31.667 120 74 2 73 192 55 166 1.63E-11 67 FRRS1_DANRE reviewed Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) 573 0 GO:0016021; GO:0016491 0 0 cd08544; PF03351;PF02014; A7MCS3 CHOYP_BRAFLDRAFT_66659.2.2 m.5672 sp CP089_DANRE 21.429 154 77 3 1 154 229 338 1.63E-06 49.7 CP089_DANRE reviewed UPF0764 protein C16orf89 homolog 0 Danio rerio (Zebrafish) (Brachydanio rerio) 351 0 GO:0005576 0 0 0 PF15882; A8DYE2 CHOYP_LOC101166883.1.2 m.22969 sp TRPCG_DROME 25.114 219 140 7 74 291 916 1111 1.63E-16 83.6 TRPCG_DROME reviewed "Transient receptor potential cation channel trpm (Transient receptor potential cation channel, subfamily M ortholog)" Trpm CG44240 Drosophila melanogaster (Fruit fly) 2023 cell growth [GO:0016049]; divalent metal ion transport [GO:0070838]; magnesium ion homeostasis [GO:0010960]; mitochondrion organization [GO:0007005]; protein tetramerization [GO:0051262]; zinc ion homeostasis [GO:0055069] GO:0005261; GO:0007005; GO:0010960; GO:0016049; GO:0034703; GO:0046873; GO:0051262; GO:0055069; GO:0070838; GO:0097682 0 0 0 PF00520;PF16519; A8TX70 CHOYP_CO6A3.5.5 m.65544 sp CO6A5_HUMAN 20.968 806 554 28 367 1126 30 798 1.63E-29 132 CO6A5_HUMAN reviewed Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) 2615 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; F1LQ48 CHOYP_LOC101175582.1.1 m.59321 sp HNRPL_RAT 46.838 585 260 14 30 592 62 617 1.63E-160 476 HNRPL_RAT reviewed Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Hnrnpl Fblim1 Rattus norvegicus (Rat) 623 "cellular response to amino acid starvation [GO:0034198]; circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to peptide [GO:1901652]" GO:0000166; GO:0000381; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006397; GO:0007623; GO:0030529; GO:0034198; GO:0035770; GO:0044212; GO:0045727; GO:0048025; GO:0048471; GO:0097157; GO:1901652; GO:1902416; GO:1990715 0 0 0 PF00076; O08762 CHOYP_BRAFLDRAFT_68915.4.7 m.5361 sp NETR_MOUSE 40.469 341 182 5 239 567 166 497 1.63E-70 254 NETR_MOUSE reviewed Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12) Prss12 Bssp3 Mus musculus (Mouse) 761 exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202 0 0 cd00190; PF00051;PF00530;PF00089; O15027 CHOYP_LOC100888527.1.1 m.1453 sp SC16A_HUMAN 44.516 620 288 14 865 1438 1104 1713 1.63E-146 511 SC16A_HUMAN reviewed Protein transport protein Sec16A (SEC16 homolog A) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) 2179 COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031]; substantia nigra development [GO:0021762] GO:0000139; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0007029; GO:0015031; GO:0021762; GO:0048208 0 0 0 PF12932;PF12931; O35900 CHOYP_LSM2.1.2 m.54283 sp LSM2_MOUSE 92.632 95 7 0 24 118 1 95 1.63E-61 186 LSM2_MOUSE reviewed U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (snRNP core Sm-like protein Sm-x5) Lsm2 G7b Mus musculus (Mouse) 95 "mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000398; GO:0000932; GO:0005688; GO:0005737; GO:0006402; GO:0017160; GO:0019901; GO:0044822; GO:0046540; GO:0071011; GO:0071013; GO:1990726 0 0 cd01725; PF01423; O43837 CHOYP_BRAFLDRAFT_124233.1.1 m.26105 sp IDH3B_HUMAN 66.374 342 113 2 40 380 41 381 1.63E-165 471 IDH3B_HUMAN reviewed "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta)" IDH3B Homo sapiens (Human) 385 2-oxoglutarate metabolic process [GO:0006103]; isocitrate metabolic process [GO:0006102]; NADH metabolic process [GO:0006734]; tricarboxylic acid cycle [GO:0006099] GO:0000287; GO:0004449; GO:0005634; GO:0005739; GO:0005759; GO:0006099; GO:0006102; GO:0006103; GO:0006734; GO:0009055; GO:0051287 0 0 0 PF00180; O70277 CHOYP_LOC100368020.27.29 m.60172 sp TRIM3_RAT 22.901 131 99 2 43 173 115 243 1.63E-07 53.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70595 CHOYP_ABCB6.1.3 m.6179 sp ABCB6_RAT 66.133 375 123 1 1 375 459 829 1.63E-163 483 ABCB6_RAT reviewed "ATP-binding cassette sub-family B member 6, mitochondrial (Ubiquitously-expressed mammalian ABC half transporter)" Abcb6 Umat Rattus norvegicus (Rat) 836 brain development [GO:0007420]; cellular iron ion homeostasis [GO:0006879]; porphyrin-containing compound biosynthetic process [GO:0006779]; skin development [GO:0043588]; transmembrane transport [GO:0055085] GO:0005524; GO:0005739; GO:0005743; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0006779; GO:0006879; GO:0007420; GO:0015439; GO:0015562; GO:0016021; GO:0020037; GO:0031307; GO:0042626; GO:0043588; GO:0055085; GO:0070062 0 0 0 PF00664;PF00005;PF16185; O75382 CHOYP_BRAFLDRAFT_79377.12.30 m.32870 sp TRIM3_HUMAN 27.155 232 147 10 221 441 485 705 1.63E-12 73.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02553 CHOYP_LOC585338.1.2 m.19087 sp TBA_LYTPI 93.396 106 6 1 101 206 27 131 1.63E-67 207 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P18433 CHOYP_LOC100632819.1.1 m.18693 sp PTPRA_HUMAN 27.907 473 316 12 1 458 338 800 1.63E-47 178 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P24733 CHOYP_MYS.2.7 m.2075 sp MYS_ARGIR 79.646 113 23 0 1 113 1808 1920 1.63E-52 181 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P25455 CHOYP_LOC100120894.1.1 m.15772 sp PIP1_DROME 22.5 120 93 0 170 289 1108 1227 1.63E-06 53.5 PIP1_DROME reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II (EC 3.1.4.11) (Phosphoinositide phospholipase C)" Plc21C plc-21 CG4574 Drosophila melanogaster (Fruit fly) 1318 flight behavior [GO:0007629]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; neuron cellular homeostasis [GO:0070050]; regulation of neuromuscular synaptic transmission [GO:1900073] GO:0004435; GO:0004871; GO:0005509; GO:0005622; GO:0007629; GO:0016042; GO:0035556; GO:0070050; GO:1900073 0 0 0 PF09279;PF00388;PF00387; P31006 CHOYP_CORT_0E05220.1.1 m.2210 sp KGUA_PIG 60.606 132 52 0 2 133 3 134 1.63E-55 174 KGUA_PIG reviewed Guanylate kinase (EC 2.7.4.8) (GMP kinase) GUK1 GUK Sus scrofa (Pig) 198 drug metabolic process [GO:0017144]; purine nucleotide metabolic process [GO:0006163] GO:0004385; GO:0005524; GO:0005829; GO:0006163; GO:0017144; GO:0019201 0 0 0 PF00625; P48723 CHOYP_NEMVEDRAFT_V1G243437.1.1 m.10097 sp HSP13_HUMAN 50 466 189 5 1 425 1 463 1.63E-149 436 HSP13_HUMAN reviewed Heat shock 70 kDa protein 13 (Microsomal stress-70 protein ATPase core) (Stress-70 protein chaperone microsome-associated 60 kDa protein) HSPA13 STCH Homo sapiens (Human) 471 0 GO:0005524; GO:0005783; GO:0043231; GO:0070062 0 0 0 PF00012; P49013 CHOYP_LOC100378275.1.1 m.20412 sp FBP3_STRPU 41.275 298 164 9 134 420 194 491 1.63E-64 219 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P74148 CHOYP_NEMVEDRAFT_V1G236573.1.2 m.46431 sp Y1388_SYNY3 27.152 151 103 2 2 146 5 154 1.63E-12 64.3 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q01768 CHOYP_NDKB.1.1 m.24475 sp NDKB_MOUSE 69.079 152 47 0 17 168 1 152 1.63E-77 230 NDKB_MOUSE reviewed Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (P18) (nm23-M2) Nme2 Mus musculus (Mouse) 152 CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of apoptotic process [GO:0043066]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; regulation of apoptotic process [GO:0042981]; regulation of epidermis development [GO:0045682]; UTP biosynthetic process [GO:0006228] GO:0001726; GO:0004550; GO:0004673; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0006163; GO:0006183; GO:0006220; GO:0006228; GO:0006241; GO:0007229; GO:0009142; GO:0030027; GO:0042981; GO:0043066; GO:0043209; GO:0045618; GO:0045682; GO:0045944; GO:0046872; GO:0050679; GO:0070062; GO:0071944; GO:0098779 0 0 0 PF00334; Q0V9A9 CHOYP_LACB2.1.1 m.31957 sp LACB2_XENTR 50.347 288 139 3 6 291 3 288 1.63E-96 289 LACB2_XENTR reviewed Endoribonuclease LACTB2 (Beta-lactamase-like protein 2) (EC 3.1.27.-) lactb2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 289 "RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]" GO:0003727; GO:0004521; GO:0005759; GO:0008270; GO:0090502 0 0 0 PF00753; Q13094 CHOYP_LCP2.12.14 m.40093 sp LCP2_HUMAN 30.962 239 126 8 424 630 292 523 1.63E-19 95.9 LCP2_HUMAN reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) LCP2 Homo sapiens (Human) 533 cytokine secretion [GO:0050663]; Fc-epsilon receptor signaling pathway [GO:0038095]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; platelet activation [GO:0030168]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0030168; GO:0035556; GO:0036398; GO:0038095; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q16974 CHOYP_KPC1.1.2 m.30648 sp KPC1_APLCA 79.771 262 53 0 1 262 385 646 1.63E-157 456 KPC1_APLCA reviewed Calcium-dependent protein kinase C (EC 2.7.11.13) (APL I) PRKC1 Aplysia californica (California sea hare) 649 intracellular signal transduction [GO:0035556] GO:0004697; GO:0005524; GO:0005737; GO:0008270; GO:0035556 0 0 0 PF00130;PF00168;PF00069;PF00433; Q29550 CHOYP_LOC100674643.1.1 m.13886 sp EST1_PIG 40.356 337 167 7 31 342 35 362 1.63E-67 225 EST1_PIG reviewed Liver carboxylesterase (EC 3.1.1.1) (Proline-beta-naphthylamidase) (Retinyl ester hydrolase) (REH) 0 Sus scrofa (Pig) 566 0 GO:0005788; GO:0052689 0 0 0 PF00135; Q2KIS9 CHOYP_DPSE_GA18582.1.1 m.58686 sp TSN8_BOVIN 21.198 217 144 6 58 273 47 237 1.63E-06 51.6 TSN8_BOVIN reviewed Tetraspanin-8 (Tspan-8) TSPAN8 Bos taurus (Bovine) 238 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q2YDN6 CHOYP_RPF2.1.2 m.26150 sp RPF2_BOVIN 67.619 105 34 0 2 106 3 107 1.63E-46 154 RPF2_BOVIN reviewed Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog) RPF2 BXDC1 Bos taurus (Bovine) 306 "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit assembly [GO:0000027]" GO:0000027; GO:0000463; GO:0005730; GO:0019843 0 0 0 PF04427; Q3KRF3 CHOYP_contig_012619 m.14527 sp CA131_RAT 33.333 120 69 3 161 270 154 272 1.63E-07 55.1 CA131_RAT reviewed Uncharacterized protein C1orf131 homolog 0 Rattus norvegicus (Rat) 282 0 GO:0005694; GO:0044822 0 0 0 PF15375; Q3T0L2 CHOYP_ERP44.1.1 m.3853 sp ERP44_BOVIN 51.456 412 175 3 38 449 16 402 1.63E-148 431 ERP44_BOVIN reviewed Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) ERP44 TXNDC4 Bos taurus (Bovine) 406 cell redox homeostasis [GO:0045454]; glycoprotein metabolic process [GO:0009100]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] GO:0003756; GO:0005783; GO:0005788; GO:0005789; GO:0005793; GO:0006457; GO:0006986; GO:0009100; GO:0009986; GO:0034976; GO:0045454; GO:0070062 0 0 0 PF00085; Q587J7 CHOYP_BRAFLDRAFT_120982.1.2 m.9680 sp TDR12_HUMAN 32.184 696 450 11 612 1301 411 1090 1.63E-106 374 TDR12_HUMAN reviewed Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12) TDRD12 ECAT8 Homo sapiens (Human) 1177 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; positive regulation of protein targeting to mitochondrion [GO:1903955]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283] GO:0003676; GO:0004004; GO:0005524; GO:0007140; GO:0007275; GO:0007283; GO:0009566; GO:0010501; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:1903955; GO:1990923 0 0 0 PF00270;PF00567; Q58DA0 CHOYP_LOC658092.1.2 m.22901 sp PSMD4_BOVIN 62.079 356 125 5 485 840 14 359 1.63E-136 414 PSMD4_BOVIN reviewed 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) PSMD4 Bos taurus (Bovine) 382 proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0005634; GO:0005654; GO:0005829; GO:0008540; GO:0022624; GO:0031593; GO:0043161; GO:0043248; GO:0044822 0 0 0 PF02809;PF13519; Q5BIM1 CHOYP_TRIM6.1.2 m.59820 sp TRI45_BOVIN 25.833 240 144 8 11 235 122 342 1.63E-07 56.2 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5EA79 CHOYP_BRAFLDRAFT_284587.3.3 m.26954 sp GALM_BOVIN 52.716 313 144 3 80 390 31 341 1.63E-113 338 GALM_BOVIN reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM Bos taurus (Bovine) 342 galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006] GO:0004034; GO:0005737; GO:0006006; GO:0006012; GO:0030246; GO:0070062 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; Q5M9N0 CHOYP_LOC100373433.1.1 m.34940 sp CD158_HUMAN 27.371 1107 716 19 179 1265 75 1113 1.63E-90 320 CD158_HUMAN reviewed Coiled-coil domain-containing protein 158 CCDC158 Homo sapiens (Human) 1113 0 0 0 0 0 PF15921; Q63ZL2 CHOYP_CALM.1.50 m.726 sp HOP2_XENLA 50.467 214 104 1 1 212 1 214 1.63E-75 229 HOP2_XENLA reviewed Homologous-pairing protein 2 homolog (PSMC3-interacting protein) (Proteasome 26S ATPase subunit 3-interacting protein) psmc3ip Xenopus laevis (African clawed frog) 214 DNA recombination [GO:0006310]; meiotic cell cycle [GO:0051321] GO:0005634; GO:0006310; GO:0051321 0 0 0 PF07106; Q6DN14 CHOYP_LOC100678876.1.1 m.11036 sp MCTP1_HUMAN 26.012 346 193 13 3 308 265 587 1.63E-16 87.4 MCTP1_HUMAN reviewed Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) 999 calcium-mediated signaling [GO:0019722] GO:0005509; GO:0005783; GO:0016021; GO:0019722 0 0 0 PF00168;PF08372; Q6IE24 CHOYP_LOC100186936.2.2 m.33291 sp UBP54_RAT 57.27 337 140 3 38 373 30 363 1.63E-124 433 UBP54_RAT reviewed Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54) Usp54 Rattus norvegicus (Rat) 1588 protein deubiquitination [GO:0016579] GO:0016579; GO:0036459 0 0 0 PF00443; Q6PBE5 CHOYP_SMP_143810.1.2 m.10477 sp TMM47_XENTR 23.494 166 119 5 41 204 12 171 1.63E-09 58.5 TMM47_XENTR reviewed Transmembrane protein 47 (Transmembrane 4 superfamily member 10) tmem47 tm4sf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 179 cell-cell adhesion [GO:0098609] GO:0005912; GO:0016021; GO:0030054; GO:0098609 0 0 0 0 Q6PGZ3 CHOYP_LOC590931.1.1 m.7446 sp MIPT3_DANRE 44.866 633 244 20 1 535 1 626 1.63E-140 422 MIPT3_DANRE reviewed TRAF3-interacting protein 1 traf3ip1 zgc:63522 Danio rerio (Zebrafish) (Brachydanio rerio) 629 cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; pronephros development [GO:0048793]; regulation of microtubule cytoskeleton organization [GO:0070507] GO:0005737; GO:0005813; GO:0005929; GO:0030992; GO:0042073; GO:0042384; GO:0048793; GO:0070507 0 0 0 0 Q6XUX2 CHOYP_LOC100370896.2.4 m.20103 sp DUSTY_RAT 26.218 431 244 18 541 950 519 896 1.63E-19 98.2 DUSTY_RAT reviewed Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) Dstyk Ripk5 Rattus norvegicus (Rat) 927 cellular response to fibroblast growth factor stimulus [GO:0044344]; intracellular signal transduction [GO:0035556]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674]; protein phosphorylation [GO:0006468] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0016323; GO:0016324; GO:0030054; GO:0033674; GO:0035556; GO:0044344; GO:0045743; GO:0070374 0 0 0 PF00069; Q7SXV2 CHOYP_LOC101173755.1.2 m.52935 sp AEBP2_DANRE 38.961 231 137 2 217 443 181 411 1.63E-47 171 AEBP2_DANRE reviewed Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2 homolog) (AE-binding protein 2 homolog) aebp2 si:dkey-158p11.2 zgc:63755 Danio rerio (Zebrafish) (Brachydanio rerio) 415 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0006351; GO:0006355; GO:0016569; GO:0035098; GO:0046872 0 0 0 0 Q7T0V2 CHOYP_BACD3.1.1 m.54775 sp LTR3A_XENLA 55.462 119 53 0 2 120 3 121 1.63E-43 141 LTR3A_XENLA reviewed Ragulator complex protein LAMTOR3-A (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3-A) (Mitogen-activated protein kinase scaffold protein 1) lamtor3-a mapksp1 Xenopus laevis (African clawed frog) 123 cellular protein localization [GO:0034613]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034613; GO:0043547; GO:0071230; GO:0071986 0 0 0 PF08923; Q7T0V2 CHOYP_LTOR3.1.3 m.20929 sp LTR3A_XENLA 55.462 119 53 0 2 120 3 121 1.63E-43 141 LTR3A_XENLA reviewed Ragulator complex protein LAMTOR3-A (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3-A) (Mitogen-activated protein kinase scaffold protein 1) lamtor3-a mapksp1 Xenopus laevis (African clawed frog) 123 cellular protein localization [GO:0034613]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034613; GO:0043547; GO:0071230; GO:0071986 0 0 0 PF08923; Q864R9 CHOYP_MRP1.8.10 m.52117 sp MRP1_MACFA 55.398 352 156 1 4 355 1181 1531 1.63E-130 410 MRP1_MACFA reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 1531 0 GO:0005524; GO:0005886; GO:0016021; GO:0042626 0 0 0 PF00664;PF00005; Q86TJ5 CHOYP_LOC100142269.1.1 m.8912 sp ZN554_HUMAN 46.961 181 95 1 282 462 354 533 1.63E-46 175 ZN554_HUMAN reviewed Zinc finger protein 554 ZNF554 Homo sapiens (Human) 538 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005730; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.6.34 m.14141 sp VWDE_HUMAN 24.042 287 204 7 688 966 809 1089 1.63E-17 92 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TER0 CHOYP_LOC580251.2.5 m.27332 sp SNED1_HUMAN 35.2 125 75 2 108 227 666 789 1.63E-16 85.9 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q91653 CHOYP_LOC659151.1.1 m.8802 sp CRHBP_XENLA 37.302 252 146 6 49 297 59 301 1.63E-41 149 CRHBP_XENLA reviewed Corticotropin-releasing factor-binding protein (CRF-BP) (CRF-binding protein) (Corticotropin-releasing hormone-binding protein) (CRH-BP) crhbp e Xenopus laevis (African clawed frog) 321 0 GO:0005576; GO:0051424 0 0 0 PF05428; Q96BK5 CHOYP_LOC101168834.1.1 m.9567 sp PINX1_HUMAN 44.398 241 107 6 1 232 1 223 1.63E-50 181 PINX1_HUMAN reviewed PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1) PINX1 LPTL LPTS Homo sapiens (Human) 328 "mitotic metaphase plate congression [GO:0007080]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomeric DNA binding [GO:1904744]; protein localization to chromosome, telomeric region [GO:0070198]; protein localization to nucleolus [GO:1902570]; regulation of protein stability [GO:0031647]; regulation of telomerase activity [GO:0051972]; telomere maintenance via telomerase [GO:0007004]" GO:0000228; GO:0000776; GO:0000777; GO:0000784; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005819; GO:0007004; GO:0007080; GO:0008285; GO:0010521; GO:0031397; GO:0031647; GO:0032211; GO:0043231; GO:0051972; GO:0051974; GO:0070034; GO:0070198; GO:1902570; GO:1904357; GO:1904744; GO:1904751 0 0 0 PF01585; Q96M20 CHOYP_LOC100376104.2.2 m.45711 sp CNBD2_HUMAN 26.58 459 289 15 399 839 70 498 1.63E-26 119 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q99M80 CHOYP_PTPRK.19.20 m.64970 sp PTPRT_MOUSE 28.873 710 461 12 516 1201 764 1453 1.63E-80 293 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9HBI1 CHOYP_LOC100366754.1.1 m.49522 sp PARVB_HUMAN 66.967 333 108 1 7 339 31 361 1.63E-158 451 PARVB_HUMAN reviewed Beta-parvin (Affixin) PARVB CGI-56 Homo sapiens (Human) 364 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell projection assembly [GO:0030031]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; lamellipodium assembly [GO:0030032] GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0007155; GO:0030018; GO:0030027; GO:0030031; GO:0030032; GO:0031532; GO:0071963 0 0 0 PF00307; Q9P243 CHOYP_ZFAT.1.1 m.9201 sp ZFAT_HUMAN 28.619 1202 716 32 110 1236 54 1188 1.63E-131 438 ZFAT_HUMAN reviewed Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406) ZFAT KIAA1485 ZFAT1 ZNF406 Homo sapiens (Human) 1243 hematopoietic progenitor cell differentiation [GO:0002244]; multicellular organism development [GO:0007275]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; spongiotrophoblast layer development [GO:0060712] GO:0000977; GO:0001077; GO:0002244; GO:0003700; GO:0005634; GO:0005829; GO:0007275; GO:0045944; GO:0046872; GO:0060712 0 0 0 0 Q9R1K9 CHOYP_CETN1.1.3 m.15199 sp CETN2_MOUSE 80.233 172 34 0 25 196 1 172 1.63E-96 280 CETN2_MOUSE reviewed Centrin-2 (Caltractin isoform 1) Cetn2 Calt Mus musculus (Mouse) 172 cell division [GO:0051301]; centriole replication [GO:0007099]; mitotic nuclear division [GO:0007067]; nucleotide-excision repair [GO:0006289]; regulation of cytokinesis [GO:0032465]; spermatogenesis [GO:0007283] GO:0005509; GO:0005622; GO:0005813; GO:0005814; GO:0005929; GO:0006289; GO:0007067; GO:0007099; GO:0007283; GO:0008017; GO:0031683; GO:0032391; GO:0032465; GO:0032795; GO:0036064; GO:0051301; GO:0071942 0 0 0 PF13499; Q9R1R2 CHOYP_LOC100374974.5.16 m.20614 sp TRIM3_MOUSE 24.67 227 142 9 340 553 534 744 1.63E-07 57.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9SHU5 CHOYP_LOC100373889.4.4 m.63540 sp ARF4_ARATH 35.26 173 100 5 27 199 15 175 1.63E-19 85.5 ARF4_ARATH reviewed Probable ADP-ribosylation factor At2g15310 At2g15310 F27O10.4 Arabidopsis thaliana (Mouse-ear cress) 205 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q9U489 CHOYP_TRIM3.40.58 m.39441 sp LIN41_CAEEL 29.323 133 75 6 48 169 833 957 1.63E-07 53.9 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9ULJ7 CHOYP_LOC755512.2.5 m.22581 sp ANR50_HUMAN 38.672 256 150 2 157 407 690 943 1.63E-48 180 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VUL9 CHOYP_ISCW_ISCW004236.4.5 m.47171 sp FUCTA_DROME 29.825 285 182 9 51 326 164 439 1.63E-26 113 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q9W770 CHOYP_FAT-SPONDIN.1.1 m.56052 sp SPON1_CHICK 32.653 539 298 15 56 583 65 549 1.63E-77 271 SPON1_CHICK reviewed Spondin-1 (F-spondin) SPON1 Gallus gallus (Chicken) 802 cell adhesion [GO:0007155] GO:0005578; GO:0007155; GO:0046872 0 0 cd08544; PF02014;PF06468;PF00090; Q9WV34 CHOYP_MPP2.1.1 m.62101 sp MPP2_MOUSE 44.732 579 284 13 1 570 1 552 1.63E-163 479 MPP2_MOUSE reviewed MAGUK p55 subfamily member 2 (Discs large homolog 2) (Protein MPP2) Mpp2 Dlgh2 Mus musculus (Mouse) 552 0 0 0 0 0 PF00625;PF02828;PF00595;PF07653; Q9Y575 CHOYP_contig_047167 m.55539 sp ASB3_HUMAN 23.894 452 264 17 37 440 95 514 1.63E-19 94.4 ASB3_HUMAN reviewed Ankyrin repeat and SOCS box protein 3 (ASB-3) ASB3 Homo sapiens (Human) 518 intracellular signal transduction [GO:0035556] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0031625; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF13606;PF07525; Q9YIC0 CHOYP_EF1A2.1.3 m.30024 sp EF1A_ORYLA 90.805 87 8 0 29 115 250 336 1.63E-47 161 EF1A_ORYLA reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; B7LTA2 CHOYP_LOC100123027.1.1 m.50938 sp GHRA_ESCF3 31.707 287 182 4 62 343 35 312 1.64E-42 152 GHRA_ESCF3 reviewed Glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) (EC 1.1.1.81) (2-ketoacid reductase) ghrA EFER_1897 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) 312 0 GO:0005737; GO:0005886; GO:0016618; GO:0030267; GO:0051287 0 0 0 PF02826; O08848 CHOYP_RO60.2.6 m.25516 sp RO60_MOUSE 36.667 90 55 1 14 101 33 122 1.64E-14 70.9 RO60_MOUSE reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0034336; GO:0046872; GO:0060271 0 0 0 PF05731; O44441 CHOYP_LOC100374535.2.3 m.26026 sp ATIF2_CAEEL 52.941 68 32 0 55 122 32 99 1.64E-15 70.1 ATIF2_CAEEL reviewed "ATPase inhibitor mai-2, mitochondrial" mai-2 B0546.1 Caenorhabditis elegans 109 heme biosynthetic process [GO:0006783]; negative regulation of ATPase activity [GO:0032780]; negative regulation of nucleotide metabolic process [GO:0045980] GO:0005739; GO:0006783; GO:0032780; GO:0042030; GO:0045980; GO:0051117 0 0 0 PF04568; O55043 CHOYP_ARHG7.3.5 m.37182 sp ARHG7_RAT 45.679 648 312 16 150 771 11 644 1.64E-170 508 ARHG7_RAT reviewed Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) Arhgef7 Pak3bp Pixb Rattus norvegicus (Rat) 646 astrocyte cell migration [GO:0043615]; lamellipodium assembly [GO:0030032]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264] GO:0001726; GO:0005085; GO:0005089; GO:0005737; GO:0005925; GO:0005938; GO:0007264; GO:0019901; GO:0030027; GO:0030032; GO:0030426; GO:0035023; GO:0043065; GO:0043615 0 0 0 PF16523;PF00169;PF00621;PF07653; P10394 CHOYP_LOC100371186.1.3 m.4929 sp POL4_DROME 29.936 314 187 7 27 320 908 1208 1.64E-30 130 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P11137 CHOYP_UAFA.5.8 m.38274 sp MTAP2_HUMAN 53.077 130 48 3 1693 1814 1649 1773 1.64E-27 126 MTAP2_HUMAN reviewed Microtubule-associated protein 2 (MAP-2) MAP2 Homo sapiens (Human) 1827 central nervous system neuron development [GO:0021954]; dendrite morphogenesis [GO:0048813]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175] GO:0000226; GO:0001578; GO:0002162; GO:0005198; GO:0005730; GO:0005737; GO:0005874; GO:0005875; GO:0008017; GO:0021954; GO:0031175; GO:0043005; GO:0048813 0 0 0 PF08377;PF00418; P22942 CHOYP_BRAFLDRAFT_233542.1.2 m.588 sp OXDA_RABIT 43.066 137 74 2 9 141 203 339 1.64E-32 120 OXDA_RABIT reviewed D-amino-acid oxidase (DAAO) (DAMOX) (DAO) (EC 1.4.3.3) DAO Oryctolagus cuniculus (Rabbit) 347 D-amino acid metabolic process [GO:0046416] GO:0003884; GO:0005777; GO:0046416; GO:0071949 0 0 0 PF01266; P29520 CHOYP_EF-1A.6.9 m.43621 sp EF1A_BOMMO 75.884 311 31 3 1 309 14 282 1.64E-162 464 EF1A_BOMMO reviewed Elongation factor 1-alpha (EF-1-alpha) 0 Bombyx mori (Silk moth) 463 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; P29755 CHOYP_SMP_072450.1.2 m.210 sp AGTRB_MOUSE 27.136 199 125 6 48 231 39 232 1.64E-08 58.9 AGTRB_MOUSE reviewed Type-1B angiotensin II receptor (AT3) (Angiotensin II type-1B receptor) (AT1B) Agtr1b Mus musculus (Mouse) 359 blood vessel development [GO:0001568]; cellular response to dexamethasone stimulus [GO:0071549]; drinking behavior [GO:0042756]; inflammatory response [GO:0006954]; kidney development [GO:0001822]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of systemic arterial blood pressure by circulatory renin-angiotensin [GO:0001991]; regulation of vasoconstriction [GO:0019229]; response to drug [GO:0042493]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; response to salt stress [GO:0009651] GO:0001568; GO:0001596; GO:0001666; GO:0001822; GO:0001991; GO:0004945; GO:0005829; GO:0006954; GO:0007204; GO:0007584; GO:0009651; GO:0012506; GO:0016021; GO:0016323; GO:0017046; GO:0019229; GO:0031983; GO:0035094; GO:0035902; GO:0042493; GO:0042756; GO:0043627; GO:0071549; GO:0090190 0 0 0 PF00001; P34269 CHOYP_CBR-TYR-4.1.1 m.11903 sp TYR1_CAEEL 33.224 304 181 8 45 331 103 401 1.64E-46 170 TYR1_CAEEL reviewed Putative tyrosinase-like protein tyr-1 tyr-1 C02C2.1/C02C2.2 Caenorhabditis elegans 601 0 GO:0004497; GO:0046872 0 0 0 PF01549;PF00264; P42577 CHOYP_LOC100881468.1.1 m.61703 sp FRIS_LYMST 86.047 86 12 0 1 86 1 86 1.64E-50 160 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P49880 CHOYP_ECR.1.1 m.28368 sp ECR_AEDAE 39.735 453 240 12 48 481 231 669 1.64E-87 287 ECR_AEDAE reviewed Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (AaEcR) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1) EcR NR1H1 AAEL009600 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 776 "transcription, DNA-templated [GO:0006351]" GO:0004884; GO:0005496; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; P49900 CHOYP_ARGI.2.2 m.8946 sp ARGI_LITCT 54.921 315 140 2 32 345 7 320 1.64E-119 351 ARGI_LITCT reviewed "Arginase, hepatic (EC 3.5.3.1)" 0 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 323 arginine metabolic process [GO:0006525]; urea cycle [GO:0000050] GO:0000050; GO:0004053; GO:0006525; GO:0046872 PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000250|UniProtKB:P05089}. 0 0 PF00491; P62285 CHOYP_LOC100697832.1.1 m.16924 sp ASPM_BOVIN 33.908 174 110 2 9 182 1399 1567 1.64E-15 77.4 ASPM_BOVIN reviewed Abnormal spindle-like microcephaly-associated protein homolog (Fragment) ASPM Bos taurus (Bovine) 3371 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; spindle organization [GO:0007051] GO:0005634; GO:0005737; GO:0005819; GO:0007051; GO:0007067; GO:0051301 0 0 0 PF15780;PF00307;PF00612; P97864 CHOYP_CASP7.22.23 m.66704 sp CASP7_MOUSE 45.993 287 146 4 17 301 23 302 1.64E-86 264 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q06852 CHOYP_NEMVEDRAFT_V1G208691.4.10 m.20746 sp SLAP1_CLOTH 52.202 613 177 45 1481 2007 1379 1961 1.64E-35 152 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0VC16 CHOYP_LOC100373461.2.2 m.61873 sp MIA3_BOVIN 28.442 552 338 15 1076 1595 1145 1671 1.64E-38 162 MIA3_BOVIN reviewed Melanoma inhibitory activity protein 3 (Transport and Golgi organization protein 1) MIA3 TANGO1 Bos taurus (Bovine) 1905 cargo loading into COPII-coated vesicle [GO:0090110]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031] GO:0000139; GO:0005789; GO:0006887; GO:0006888; GO:0015031; GO:0016021; GO:0042953; GO:0042954; GO:0070971; GO:0090110 0 0 0 PF07653; Q12955 CHOYP_LOC100639010.6.9 m.46635 sp ANK3_HUMAN 32.172 373 253 0 3 375 369 741 1.64E-61 218 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q20930 CHOYP_ADAMTS18.2.2 m.25110 sp MIG17_CAEEL 30.719 306 188 11 281 577 214 504 1.64E-28 124 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q23915 CHOYP_contig_051697 m.61855 sp KINX_DICDI 59.459 74 25 2 19 87 895 968 1.64E-08 57.4 KINX_DICDI reviewed Probable serine/threonine-protein kinase kinX (EC 2.7.11.1) kinX DDB_G0283391 Dictyostelium discoideum (Slime mold) 1094 0 GO:0004674; GO:0005524 0 0 0 PF07714; Q24307 CHOYP_AAEL_AAEL009074.2.3 m.25223 sp DIAP2_DROME 43.243 74 42 0 113 186 425 498 1.64E-16 79.7 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q24799 CHOYP_MYPH.1.2 m.36560 sp MYPH_ECHGR 65.891 129 43 1 1 128 62 190 1.64E-56 177 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q3U4G3 CHOYP_C3ORF21.1.2 m.18715 sp XXLT1_MOUSE 39.301 229 128 4 79 297 97 324 1.64E-54 184 XXLT1_MOUSE reviewed "Xyloside xylosyltransferase 1 (EC 2.4.2.n3) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)" Xxylt1 Mus musculus (Mouse) 392 0 GO:0005789; GO:0016021; GO:0016763 0 0 0 PF01501; Q502M6 CHOYP_LOC100641729.3.10 m.23123 sp ANR29_DANRE 41.447 152 89 0 12 163 36 187 1.64E-33 122 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q54I71 CHOYP_LDBPK_300810.1.1 m.29406 sp AARA_DICDI 21.965 346 239 9 119 444 410 744 1.64E-12 74.7 AARA_DICDI reviewed Protein aardvark (Suppressor of amiB protein 16) aarA aar sab6 DDB_G0288877 Dictyostelium discoideum (Slime mold) 757 cell adhesion [GO:0007155]; cell motility [GO:0048870]; cellular protein localization [GO:0034613]; centrosome localization [GO:0051642]; culmination involved in sorocarp development [GO:0031154]; epithelial cell morphogenesis [GO:0003382]; establishment or maintenance of bipolar cell polarity [GO:0061245]; Golgi localization [GO:0051645]; positive regulation of cytoskeleton organization [GO:0051495]; protein secretion [GO:0009306]; regulation of gene expression [GO:0010468]; sorocarp spore cell differentiation [GO:0044671]; sorocarp stalk development [GO:0031150]; sorocarp stalk morphogenesis [GO:0036360] GO:0003382; GO:0005737; GO:0005813; GO:0005911; GO:0005912; GO:0007155; GO:0009306; GO:0010468; GO:0031150; GO:0031154; GO:0034613; GO:0036360; GO:0044671; GO:0045180; GO:0045294; GO:0048870; GO:0051495; GO:0051642; GO:0051645; GO:0061245 0 0 0 0 Q5DTT8 CHOYP_LOC100708199.1.6 m.14241 sp PNMA5_MOUSE 34.615 130 82 1 90 216 159 288 1.64E-09 62.8 PNMA5_MOUSE reviewed Paraneoplastic antigen-like protein 5 Pnma5 Kiaa1934 Mus musculus (Mouse) 618 0 GO:0042802 0 0 0 PF14893; Q5SSZ7 CHOYP_LOC100727159.1.1 m.60272 sp ZNRF3_MOUSE 44.444 288 152 3 18 302 53 335 1.64E-75 267 ZNRF3_MOUSE reviewed E3 ubiquitin-protein ligase ZNRF3 (EC 6.3.2.-) (Zinc/RING finger protein 3) Znrf3 Mus musculus (Mouse) 913 "canonical Wnt signaling pathway [GO:0060070]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of Wnt signaling pathway [GO:0030178]; protein ubiquitination [GO:0016567]; stem cell proliferation [GO:0072089]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt receptor catabolic process [GO:0038018]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0004842; GO:0005109; GO:0005887; GO:0006511; GO:0008270; GO:0016567; GO:0016874; GO:0030178; GO:0038018; GO:0060070; GO:0060071; GO:0072089; GO:0090090; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q5ZIQ3 CHOYP_PHUM_PHUM593000.1.1 m.54007 sp HNRPK_CHICK 52.033 123 42 3 41 148 296 416 1.64E-23 98.2 HNRPK_CHICK reviewed Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK RCJMB04_24e23 Gallus gallus (Chicken) 427 "mRNA processing [GO:0006397]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005654; GO:0005681; GO:0005737; GO:0006351; GO:0006357; GO:0006397; GO:0008380 0 0 0 PF00013;PF08067; Q5ZJQ7 CHOYP_SSU72.1.1 m.2079 sp SSU72_CHICK 69.792 192 58 0 27 218 3 194 1.64E-102 297 SSU72_CHICK reviewed RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16) SSU72 RCJMB04_16f24 Gallus gallus (Chicken) 194 dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; mRNA polyadenylation [GO:0006378] GO:0005634; GO:0005737; GO:0006378; GO:0008420; GO:0070940 0 0 0 PF04722; Q6DF34 CHOYP_APCD1.1.1 m.10337 sp APCD1_XENTR 37.945 477 259 10 48 518 59 504 1.64E-92 294 APCD1_XENTR reviewed Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein homolog) apcdd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 510 negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0005887; GO:0016055; GO:0017147; GO:0030178 0 0 0 PF14921; Q6NZL8 CHOYP_LOC100640509.1.1 m.39602 sp SCUB1_MOUSE 32.843 204 118 8 69 258 652 850 1.64E-10 67 SCUB1_MOUSE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) 1018 protein homooligomerization [GO:0051260] GO:0005509; GO:0005615; GO:0009897; GO:0009986; GO:0019897; GO:0046982; GO:0051260 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q6PFY8 CHOYP_TRI46.1.3 m.21478 sp TRI45_MOUSE 29.185 233 143 7 5 224 127 350 1.64E-13 74.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6ZSS7 CHOYP_PHUM_PHUM360490.1.1 m.31455 sp MFSD6_HUMAN 54.497 189 86 0 440 628 435 623 1.64E-67 241 MFSD6_HUMAN reviewed Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) MFSD6 MMR2 Homo sapiens (Human) 791 0 GO:0016020; GO:0016021 0 0 cd06174; PF12832; Q76IC5 CHOYP_LOC100709617.1.1 m.10644 sp PGPI_RAT 51.031 194 95 0 4 197 3 196 1.64E-71 218 PGPI_RAT reviewed Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase) Pgpep1 Rattus norvegicus (Rat) 209 proteolysis [GO:0006508] GO:0005829; GO:0006508; GO:0008234; GO:0016920 0 0 cd00501; PF01470; Q7TN88 CHOYP_BRAFLDRAFT_92073.1.3 m.33874 sp PK1L2_MOUSE 27.031 640 406 14 2209 2829 1814 2411 1.64E-59 233 PK1L2_MOUSE reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) 2461 detection of mechanical stimulus [GO:0050982] GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q7TP17 CHOYP_BRAFLDRAFT_202693.1.4 m.6382 sp U2AF4_RAT 81.683 202 30 2 1 201 1 196 1.64E-121 347 U2AF4_RAT reviewed Splicing factor U2AF 26 kDa subunit (Liver regeneration-related protein LRRG157/LRRG158) (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) U2af1l4 Cb2-806 Cb2-807 Rattus norvegicus (Rat) 220 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005681; GO:0005737; GO:0016607; GO:0046872; GO:0089701 0 0 0 PF00076;PF00642; Q8CFF0 CHOYP_NAEGRDRAFT_81435.2.2 m.36000 sp PAR11_MOUSE 26.484 219 99 9 834 1034 156 330 1.64E-11 70.5 PAR11_MOUSE reviewed Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) Parp11 Mus musculus (Mouse) 331 cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; nuclear envelope organization [GO:0006998]; protein transport [GO:0015031]; spermatogenesis [GO:0007283] GO:0003950; GO:0005635; GO:0005643; GO:0006998; GO:0007283; GO:0015031; GO:0030154; GO:0051028 0 0 0 PF00644;PF02825; Q8K2C9 CHOYP_LOC100376136.1.1 m.4906 sp HACD3_MOUSE 38.611 360 210 6 12 370 6 355 1.64E-79 251 HACD3_MOUSE reviewed Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 3) (HACD3) (Butyrate-induced protein 1) (B-ind1) (Protein-tyrosine phosphatase-like A domain-containing protein 1) Hacd3 Ptplad1 Mus musculus (Mouse) 362 fatty acid elongation [GO:0030497]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; JNK cascade [GO:0007254]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; Rho protein signal transduction [GO:0007266]; very long-chain fatty acid biosynthetic process [GO:0042761] GO:0005737; GO:0005739; GO:0005783; GO:0005789; GO:0005925; GO:0007249; GO:0007254; GO:0007266; GO:0016021; GO:0018812; GO:0019899; GO:0030497; GO:0031965; GO:0042761; GO:0045070; GO:0046726; GO:0102344; GO:0102345 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q9P035}. 0 0 PF04387; Q8N2E2 CHOYP_VWDE.10.13 m.46201 sp VWDE_HUMAN 26.63 368 242 11 656 1004 749 1107 1.64E-21 105 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N2E2 CHOYP_VWDE.5.13 m.28163 sp VWDE_HUMAN 30.182 275 168 6 6 259 820 1091 1.64E-28 130 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N6F8 CHOYP_BRAFLDRAFT_93226.1.1 m.34746 sp WBS27_HUMAN 32.948 173 112 4 27 198 24 193 1.64E-27 108 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q8R173 CHOYP_BRAFLDRAFT_218835.1.2 m.9060 sp ZDHC3_MOUSE 62.121 264 99 1 59 321 36 299 1.64E-118 346 ZDHC3_MOUSE reviewed Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (GABA-A receptor-associated membrane protein 1) (Golgi-specific DHHC zinc finger protein) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) Zdhhc3 Godz Gramp1 Mus musculus (Mouse) 299 protein palmitoylation [GO:0018345]; protein targeting [GO:0006605] GO:0000139; GO:0005794; GO:0006605; GO:0008270; GO:0016020; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q92010 CHOYP_LOC100537049.1.1 m.11977 sp ZBT14_CHICK 35.172 145 81 4 605 739 236 377 1.64E-15 83.2 ZBT14_CHICK reviewed Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 5) (ZF5) ZBTB14 ZFP161 Gallus gallus (Chicken) 448 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0044212; GO:0045892; GO:0046872 0 0 0 PF00651;PF00096; Q92752 CHOYP_BRAFLDRAFT_88602.3.3 m.21185 sp TENR_HUMAN 43.878 196 104 3 80 272 1150 1342 1.64E-51 184 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q9BRZ2 CHOYP_TIF1B.6.10 m.24697 sp TRI56_HUMAN 23.81 231 156 6 15 227 19 247 1.64E-08 61.6 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9BXF9 CHOYP_LOC100181355.1.1 m.48652 sp TEKT3_HUMAN 52.174 506 224 8 35 540 1 488 1.64E-177 512 TEKT3_HUMAN reviewed Tektin-3 TEKT3 Homo sapiens (Human) 490 cilium morphogenesis [GO:0060271]; regulation of fertilization [GO:0080154]; sperm motility [GO:0030317] GO:0002080; GO:0005634; GO:0005874; GO:0030317; GO:0036126; GO:0060271; GO:0070062; GO:0080154 0 0 0 0 Q9C585 CHOYP_BRAFLDRAFT_75955.1.1 m.11097 sp UBP8_ARATH 33.974 156 83 6 631 783 730 868 1.64E-14 81.3 UBP8_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (AtUBP8) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) UBP8 At5g22030 T6G21.4 Arabidopsis thaliana (Mouse-ear cress) 871 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016579; GO:0036459 0 0 0 PF00443; Q9GZS1 CHOYP_LOC100368457.1.1 m.16218 sp RPA49_HUMAN 28.906 384 258 7 17 391 88 465 1.64E-42 158 RPA49_HUMAN reviewed DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53) POLR1E PAF53 PRAF1 Homo sapiens (Human) 481 "positive regulation of gene expression, epigenetic [GO:0045815]; RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript [GO:0001189]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription initiation from RNA polymerase I promoter [GO:0006361]" GO:0001189; GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005730; GO:0005736; GO:0006361; GO:0006362; GO:0006363; GO:0009303; GO:0045815 0 0 0 PF06870; Q9IBD8 CHOYP_PTPRE.17.19 m.55167 sp PTPRC_CYPCA 28.493 544 355 9 611 1127 563 1099 1.64E-59 227 PTPRC_CYPCA reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45) ptprc Cyprinus carpio (Common carp) 1216 T cell receptor signaling pathway [GO:0050852] GO:0004725; GO:0016021; GO:0050852 0 0 0 PF00102; Q9JI10 CHOYP_LOC100120481.1.2 m.64018 sp STK3_MOUSE 79.861 144 29 0 3 146 7 150 1.64E-79 246 STK3_MOUSE reviewed Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] Stk3 Mess1 Mst2 Mus musculus (Mouse) 497 cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation [GO:0008285]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; primitive hemopoiesis [GO:0060215]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800] GO:0000287; GO:0001841; GO:0003157; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007417; GO:0008285; GO:0032092; GO:0035329; GO:0035556; GO:0043065; GO:0043234; GO:0045600; GO:0046330; GO:0046621; GO:0046983; GO:0050821; GO:0051091; GO:0051897; GO:0060215; GO:0060706; GO:0060800; GO:0090090; GO:0097284; GO:1902043 0 0 0 PF11629;PF00069; Q9UIF8 CHOYP_BRAFLDRAFT_122791.1.6 m.8640 sp BAZ2B_HUMAN 40.561 535 278 10 494 991 731 1262 1.64E-106 384 BAZ2B_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00439;PF02791;PF01429;PF00628;PF15613; Q9X248 CHOYP_LOC100704819.1.2 m.14210 sp FABG_THEMA 38.8 250 143 5 5 253 3 243 1.64E-44 153 FABG_THEMA reviewed 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) 246 fatty acid elongation [GO:0030497] GO:0004316; GO:0030497; GO:0050661; GO:0051287; GO:0102132 PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 0 Q9YHV4 CHOYP_LOC100573370.1.1 m.22098 sp FSTA_DANRE 37.049 305 188 4 6 308 18 320 1.64E-58 196 FSTA_DANRE reviewed Follistatin-A (FS) (Activin-binding protein) (Follistatin-1) (zFst1) fsta fst fst1 si:dkey-111k10.2 si:dkeyp-88a5.1 Danio rerio (Zebrafish) (Brachydanio rerio) 322 determination of dorsal identity [GO:0048263]; dorsal/ventral pattern formation [GO:0009953]; embryonic viscerocranium morphogenesis [GO:0048703]; midbrain development [GO:0030901]; oocyte differentiation [GO:0009994]; otic placode formation [GO:0043049] GO:0005576; GO:0009953; GO:0009994; GO:0030901; GO:0043049; GO:0048263; GO:0048703 0 0 0 PF09289;PF07648; A2AVA0 CHOYP_SELE.1.2 m.33901 sp SVEP1_MOUSE 32.639 144 89 5 2 141 1927 2066 1.65E-14 73.6 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; D2GXS7 CHOYP_LOC100373444.77.79 m.63825 sp TRIM2_AILME 26.728 217 143 7 375 584 535 742 1.65E-11 70.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2A0M7 CHOYP_PLSP.5.5 m.44809 sp PLSP_PINMG 40.955 691 352 20 7 661 8 678 1.65E-132 411 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O01666 CHOYP_BRAFLDRAFT_198650.1.1 m.30511 sp ATPG_DROME 52.336 214 100 2 47 259 84 296 1.65E-75 234 ATPG_DROME reviewed "ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)" ATPsyngamma ATPsyn-gamma CG7610 Drosophila melanogaster (Fruit fly) 297 ATP synthesis coupled proton transport [GO:0015986]; phagocytosis [GO:0006909] GO:0005739; GO:0005743; GO:0005811; GO:0006909; GO:0015986; GO:0045261; GO:0046933; GO:0046961 0 0 cd12151; PF00231; O15439 CHOYP_MRP4.3.3 m.47439 sp MRP4_HUMAN 32.394 355 206 5 17 367 689 1013 1.65E-47 177 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O50655 CHOYP_LOC100632495.5.11 m.14972 sp XERD_SELRU 27.273 297 199 9 1 293 42 325 1.65E-18 87.8 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O60500 CHOYP_SNS.1.1 m.14256 sp NPHN_HUMAN 30.079 1014 650 24 52 1031 34 1022 1.65E-135 451 NPHN_HUMAN reviewed Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) 1241 cell adhesion [GO:0007155]; excretion [GO:0007588]; glomerular basement membrane development [GO:0032836]; glomerular visceral epithelial cell development [GO:0072015]; JNK cascade [GO:0007254]; myoblast fusion [GO:0007520]; positive regulation of actin filament polymerization [GO:0030838]; protein localization to synapse [GO:0035418]; regulation of excretion [GO:0044062]; skeletal muscle tissue development [GO:0007519] GO:0005622; GO:0005886; GO:0005887; GO:0007155; GO:0007254; GO:0007519; GO:0007520; GO:0007588; GO:0017022; GO:0030838; GO:0032836; GO:0035418; GO:0036057; GO:0042995; GO:0044062; GO:0070062; GO:0072015 0 0 0 PF08205;PF00041;PF07686; O70277 CHOYP_NAEGRDRAFT_70324.2.2 m.42065 sp TRIM3_RAT 25.843 178 103 6 14 180 535 694 1.65E-07 53.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88572 CHOYP_LOC578656.10.15 m.54318 sp LRP6_MOUSE 25.695 899 602 26 86 953 70 933 1.65E-83 303 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; O95210 CHOYP_LOC100490725.1.1 m.45073 sp STBD1_HUMAN 32.653 98 60 2 7 104 264 355 1.65E-07 53.5 STBD1_HUMAN reviewed Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) STBD1 GENX-3414 Homo sapiens (Human) 358 glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; muscle contraction [GO:0006936] GO:0005789; GO:0005887; GO:0005980; GO:0006936; GO:0016020; GO:0034045; GO:0048471; GO:0061723; GO:2001069; GO:2001070 0 0 0 PF00686; P00491 CHOYP_TRIADDRAFT_55525.1.1 m.53631 sp PNPH_HUMAN 53.763 279 129 0 1 279 1 279 1.65E-112 329 PNPH_HUMAN reviewed Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Homo sapiens (Human) 289 immune response [GO:0006955]; inosine catabolic process [GO:0006148]; interleukin-2 secretion [GO:0070970]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of T cell proliferation [GO:0042102]; purine-containing compound salvage [GO:0043101]; purine nucleotide catabolic process [GO:0006195]; response to drug [GO:0042493]; urate biosynthetic process [GO:0034418] GO:0001882; GO:0002060; GO:0004731; GO:0005622; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0006139; GO:0006148; GO:0006195; GO:0006738; GO:0006955; GO:0008144; GO:0034356; GO:0034418; GO:0042102; GO:0042301; GO:0042493; GO:0043101; GO:0046638; GO:0070062; GO:0070970 PATHWAY: Purine metabolism; purine nucleoside salvage. 0 0 PF01048; P04323 CHOYP_LOC100372999.2.3 m.45128 sp POL3_DROME 38.967 213 124 3 5 216 377 584 1.65E-39 147 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P07207 CHOYP_NOTC3.1.1 m.20877 sp NOTCH_DROME 34.459 296 165 11 24 300 429 714 1.65E-26 121 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P16157 CHOYP_LOC581927.25.27 m.59935 sp ANK1_HUMAN 30 400 250 6 22 402 139 527 1.65E-43 166 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17267 CHOYP_RL23.4.11 m.13922 sp IF_RAT 27.76 317 174 17 143 417 92 395 1.65E-09 63.2 IF_RAT reviewed Gastric intrinsic factor (Intrinsic factor) (IF) (INF) Gif Rattus norvegicus (Rat) 417 cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; cobalt ion transport [GO:0006824] GO:0005576; GO:0006824; GO:0009235; GO:0015889; GO:0019842; GO:0031419 0 0 0 PF01122; P20273 CHOYP_PHUM_PHUM427190.1.1 m.57126 sp CD22_HUMAN 25 336 220 13 140 454 132 456 1.65E-21 104 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P20825 CHOYP_POLY.1.1 m.47737 sp POL2_DROME 44.828 145 74 1 18 162 484 622 1.65E-33 127 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P23588 CHOYP_LOC100374651.2.4 m.34409 sp IF4B_HUMAN 42.745 255 105 5 13 226 14 268 1.65E-41 163 IF4B_HUMAN reviewed Eukaryotic translation initiation factor 4B (eIF-4B) EIF4B Homo sapiens (Human) 611 cytoplasmic translation [GO:0002181]; eukaryotic translation initiation factor 4F complex assembly [GO:0097010]; formation of translation preinitiation complex [GO:0001731]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0000166; GO:0000289; GO:0001731; GO:0002181; GO:0003723; GO:0003743; GO:0004386; GO:0005829; GO:0005844; GO:0006413; GO:0006446; GO:0016281; GO:0033592; GO:0034057; GO:0043024; GO:0044822; GO:0097010 0 0 0 PF00076; P49963 CHOYP_LOC100743492.1.1 m.58896 sp SRP19_DROME 49.63 135 66 2 31 165 11 143 1.65E-38 132 SRP19_DROME reviewed Signal recognition particle 19 kDa protein (SRP19) Srp19 CG4457 Drosophila melanogaster (Fruit fly) 160 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005786; GO:0006614; GO:0008312 0 0 0 PF01922; P53013 CHOYP_EEF1A.3.3 m.37434 sp EF1A_CAEEL 80.208 96 19 0 1 96 155 250 1.65E-51 171 EF1A_CAEEL reviewed Elongation factor 1-alpha (EF-1-alpha) eft-3 F31E3.5; eft-4 R03G5.1 Caenorhabditis elegans 463 embryo development ending in birth or egg hatching [GO:0009792]; growth [GO:0040007] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0008135; GO:0009792; GO:0040007 0 0 0 PF03144;PF03143; P57721 CHOYP_LOC100905944.1.1 m.37121 sp PCBP3_HUMAN 56.863 357 107 5 18 368 46 361 1.65E-125 372 PCBP3_HUMAN reviewed Poly(rC)-binding protein 3 (Alpha-CP3) PCBP3 Homo sapiens (Human) 371 mRNA metabolic process [GO:0016071] GO:0003677; GO:0003723; GO:0005634; GO:0005829; GO:0016071; GO:0030529; GO:0044822; GO:0070062 0 0 0 PF00013; P60924 CHOYP_OLAH.2.2 m.28729 sp DELE_RAT 35.602 191 121 1 1 189 234 424 1.65E-30 126 DELE_RAT reviewed Death ligand signal enhancer Dele Rattus norvegicus (Rat) 509 extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281] GO:0005739; GO:0008625; GO:0043281 0 0 0 PF08238; Q02543 CHOYP_RL18A.6.8 m.61646 sp RL18A_HUMAN 70.455 176 52 0 31 206 1 176 1.65E-90 266 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q03049 CHOYP_LOC100376187.2.2 m.55240 sp YD541_YEAST 36.972 284 156 8 68 331 5 285 1.65E-49 176 YD541_YEAST reviewed Putative uncharacterized oxidoreductase YDR541C (EC 1.1.1.-) YDR541C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 344 response to furfural [GO:1901426] GO:0033721; GO:0050662; GO:1901426 0 0 0 PF01370; Q05695 CHOYP_ISCW_ISCW020054.1.1 m.58472 sp L1CAM_RAT 23.64 478 320 18 40 502 48 495 1.65E-25 115 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q09654 CHOYP_LOC100175640.6.7 m.42069 sp TRI23_CAEEL 30.097 103 64 4 24 120 119 219 1.65E-06 52.8 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q12955 CHOYP_TVAG_388180.3.8 m.21053 sp ANK3_HUMAN 36.842 133 84 0 3 135 63 195 1.65E-23 98.6 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q16932 CHOYP_STX.1.1 m.30392 sp STX_APLCA 82.609 276 46 1 1 276 1 274 1.65E-163 458 STX_APLCA reviewed Syntaxin 0 Aplysia californica (California sea hare) 290 intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neurotransmitter transport [GO:0006836]; regulation of exocytosis [GO:0017157]; vesicle-mediated transport [GO:0016192] GO:0005622; GO:0006836; GO:0006886; GO:0016021; GO:0016192; GO:0017157; GO:0061025 0 0 0 PF05739;PF00804; Q27403 CHOYP_LOC410334.1.1 m.12947 sp GCM_DROME 69.281 153 47 0 43 195 34 186 1.65E-73 246 GCM_DROME reviewed Transcription factor glial cells missing (Protein glide) gcm CG12245 Drosophila melanogaster (Fruit fly) 504 "cell proliferation [GO:0008283]; dendrite morphogenesis [GO:0048813]; embryonic crystal cell differentiation [GO:0035165]; embryonic plasmatocyte differentiation [GO:0035164]; establishment of glial blood-brain barrier [GO:0060857]; glial cell development [GO:0021782]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; gliogenesis [GO:0042063]; hemocyte development [GO:0007516]; hemopoiesis [GO:0030097]; lymph gland plasmatocyte differentiation [GO:0035169]; negative regulation of crystal cell differentiation [GO:0042690]; neuron differentiation [GO:0030182]; plasmatocyte differentiation [GO:0042387]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; posterior head segmentation [GO:0035289]; regulation of gene expression [GO:0010468]; regulation of hemocyte differentiation [GO:0045610]; regulation of phagocytosis [GO:0050764]; regulation of transcription, DNA-templated [GO:0006355]; retinal ganglion cell axon guidance [GO:0031290]" GO:0001077; GO:0001158; GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0007403; GO:0007516; GO:0008283; GO:0010001; GO:0010468; GO:0010628; GO:0021782; GO:0030097; GO:0030182; GO:0031290; GO:0035164; GO:0035165; GO:0035169; GO:0035289; GO:0042063; GO:0042387; GO:0042690; GO:0045610; GO:0045687; GO:0045893; GO:0045944; GO:0048813; GO:0050764; GO:0060252; GO:0060857 0 0 0 PF03615; Q2EMV9 CHOYP_LOC100705484.1.1 m.62105 sp PAR14_MOUSE 27.464 619 357 22 8 567 813 1398 1.65E-42 172 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q2KHZ4 CHOYP_BRAFLDRAFT_130502.1.1 m.49769 sp MIA40_BOVIN 40.541 111 60 2 1 111 1 105 1.65E-24 94 MIA40_BOVIN reviewed Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) CHCHD4 MIA40 Bos taurus (Bovine) 137 'de novo' posttranslational protein folding [GO:0051084]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation by protein folding [GO:0022417] GO:0005758; GO:0015035; GO:0022417; GO:0045041; GO:0051084 0 0 0 PF06747; Q3SZ76 CHOYP_LOC100371611.1.1 m.23697 sp COMD3_BOVIN 39.691 194 117 0 16 209 1 194 1.65E-46 155 COMD3_BOVIN reviewed COMM domain-containing protein 3 COMMD3 Bos taurus (Bovine) 195 "regulation of transcription, DNA-templated [GO:0006355]; sodium ion transport [GO:0006814]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006814 0 0 0 PF07258; Q3T052 CHOYP_LOC100567114.1.1 m.39091 sp ITIH4_BOVIN 33.577 822 476 19 48 833 36 823 1.65E-110 364 ITIH4_BOVIN reviewed Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) ITIH4 Bos taurus (Bovine) 916 acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212] GO:0004867; GO:0005576; GO:0006953; GO:0030212 0 0 0 PF06668;PF08487;PF00092; Q49LS8 CHOYP_XKR6.1.1 m.53529 sp XKR6_TETNG 27.119 295 193 4 122 407 87 368 1.65E-22 103 XKR6_TETNG reviewed XK-related protein 6 xkr6 xrg6 GSTENG00030285001 GSTENG00030286001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 578 0 GO:0016021 0 0 0 PF09815; Q4UMH6 CHOYP_contig_004403 m.5027 sp Y381_RICFE 32.42 219 126 3 44 262 964 1160 1.65E-16 84.3 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q561T9 CHOYP_LERL1.1.1 m.40764 sp OBRG_DANRE 63.115 122 41 3 34 153 7 126 1.65E-43 143 OBRG_DANRE reviewed Leptin receptor gene-related protein (Endospanin-1) (OB-R gene-related protein) (OB-RGRP) leprot lepr-grp zgc:112430 Danio rerio (Zebrafish) (Brachydanio rerio) 130 0 GO:0000139; GO:0010008; GO:0016021 0 0 0 PF04133; Q5DU00 CHOYP_LOC100890540.1.2 m.44220 sp DCDC2_MOUSE 28.954 411 231 14 33 430 18 380 1.65E-34 140 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q5R4Q3 CHOYP_LOC100373522.1.5 m.12052 sp SEC62_PONAB 39.37 381 197 6 456 814 8 376 1.65E-66 229 SEC62_PONAB reviewed Translocation protein SEC62 (Translocation protein 1) (TP-1) SEC62 TLOC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 399 posttranslational protein targeting to membrane [GO:0006620] GO:0005789; GO:0005791; GO:0006620; GO:0008565; GO:0016021; GO:0016235; GO:0045111 0 0 0 PF03839; Q5R7A4 CHOYP_PHUM_PHUM310360.1.1 m.21767 sp RAB7L_PONAB 60.116 173 69 0 10 182 7 179 1.65E-77 234 RAB7L_PONAB reviewed Ras-related protein Rab-7L1 (Rab-7-like protein 1) RAB29 RAB7L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 203 "Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; negative regulation of neuron projection development [GO:0010977]; positive regulation of intracellular protein transport [GO:0090316]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde transport, plasma membrane to Golgi [GO:0035526]; small GTPase mediated signal transduction [GO:0007264]" GO:0003924; GO:0005525; GO:0005737; GO:0005802; GO:0005829; GO:0005856; GO:0005886; GO:0006895; GO:0007030; GO:0007264; GO:0010977; GO:0015031; GO:0019003; GO:0035526; GO:0042147; GO:0048471; GO:0070062; GO:0090316 0 0 0 PF00071; Q5THR3 CHOYP_LOC100185585.1.1 m.20011 sp EFCB6_HUMAN 33.043 115 71 2 68 182 121 229 1.65E-10 65.1 EFCB6_HUMAN reviewed EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) 1501 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q60847 CHOYP_BRAFLDRAFT_92090.5.7 m.64409 sp COCA1_MOUSE 41.53 183 99 4 28 205 438 617 1.65E-30 130 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q6BEA0 CHOYP_ISCW_ISCW007151.1.2 m.41781 sp PLXA4_DANRE 24.771 1312 793 45 35 1232 52 1283 1.65E-96 349 PLXA4_DANRE reviewed Plexin-A4 plxna4 Danio rerio (Zebrafish) (Brachydanio rerio) 1903 axonal defasciculation [GO:0007414]; axon guidance [GO:0007411]; branchiomotor neuron axon guidance [GO:0021785]; morphogenesis of a branching structure [GO:0001763]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0001763; GO:0002116; GO:0005887; GO:0007411; GO:0007414; GO:0016021; GO:0017154; GO:0021785; GO:0030334; GO:0048841; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q6DIB5 CHOYP_MEG10.88.91 m.64696 sp MEG10_MOUSE 39.521 334 165 18 187 504 259 571 1.65E-41 165 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6GLT8 CHOYP_LOC763463.1.1 m.1366 sp FAHD2_XENLA 59.31 290 114 2 1 288 32 319 1.65E-130 376 FAHD2_XENLA reviewed Fumarylacetoacetate hydrolase domain-containing protein 2 (EC 3.-.-.-) fahd2 fahd2a Xenopus laevis (African clawed frog) 319 metabolic process [GO:0008152] GO:0008152; GO:0016787; GO:0046872 0 0 0 PF01557; Q6NRD5 CHOYP_EXD1.1.1 m.18770 sp EXD1_XENLA 36.321 212 132 1 1 212 97 305 1.65E-36 147 EXD1_XENLA reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) exd1 exdl1 Xenopus laevis (African clawed frog) 444 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q6NVT7 CHOYP_FOXC-LIKE.1.1 m.10155 sp FOXC2_XENTR 40.117 511 205 25 24 495 13 461 1.65E-76 250 FOXC2_XENTR reviewed Forkhead box protein C2 (FoxC2) foxc2 TGas062l07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 464 "insulin receptor signaling pathway [GO:0008286]; lymphangiogenesis [GO:0001946]; mesoderm development [GO:0007498]; positive regulation of transcription, DNA-templated [GO:0045893]; response to hormone [GO:0009725]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0001946; GO:0003700; GO:0005634; GO:0006351; GO:0007498; GO:0008286; GO:0009725; GO:0031490; GO:0043565; GO:0045893 0 0 0 PF00250; Q6PFY8 CHOYP_BRAFLDRAFT_84664.3.7 m.32721 sp TRI45_MOUSE 30.882 204 124 6 8 205 129 321 1.65E-14 79.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7ZU45 CHOYP_contig_027469 m.31186 sp TTC25_DANRE 48.069 466 226 3 1 462 33 486 1.65E-153 451 TTC25_DANRE reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) 486 cilium assembly [GO:0042384]; determination of heart left/right asymmetry [GO:0061371]; otolith morphogenesis [GO:0032474] GO:0032474; GO:0042384; GO:0061371 0 0 0 0 Q7ZW25 CHOYP_CHM2A.1.1 m.59752 sp CHM2A_DANRE 82.727 220 37 1 37 256 1 219 1.65E-114 330 CHM2A_DANRE reviewed Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) chmp2a bc2 Danio rerio (Zebrafish) (Brachydanio rerio) 220 exit from mitosis [GO:0010458]; nuclear envelope reassembly [GO:0031468]; protein transport [GO:0015031]; vacuolar transport [GO:0007034] GO:0005635; GO:0007034; GO:0010458; GO:0015031; GO:0031468; GO:0031902 0 0 0 PF03357; Q7ZWI4 CHOYP_LOC100888910.1.1 m.64827 sp GSKIP_DANRE 42.453 106 61 0 28 133 28 133 1.65E-30 109 GSKIP_DANRE reviewed GSK3-beta interaction protein (GSKIP) gskip zgc:55683 Danio rerio (Zebrafish) (Brachydanio rerio) 133 0 GO:0005737 0 0 0 PF05303; Q8C525 CHOYP_LOC100377311.2.14 m.3677 sp M21D2_MOUSE 32.759 174 100 7 217 384 181 343 1.65E-14 80.1 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8K0V2 CHOYP_LOC100374641.1.1 m.10626 sp DCNL3_MOUSE 44.178 292 155 4 1 290 1 286 1.65E-79 246 DCNL3_MOUSE reviewed DCN1-like protein 3 (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) Dcun1d3 Mus musculus (Mouse) 304 negative regulation of cell growth [GO:0030308]; positive regulation of apoptotic process [GO:0043065]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein neddylation [GO:0045116]; response to gamma radiation [GO:0010332]; response to radiation [GO:0009314]; response to UV-C [GO:0010225] GO:0000151; GO:0005737; GO:0005886; GO:0009314; GO:0010225; GO:0010332; GO:0030308; GO:0031624; GO:0032182; GO:0043065; GO:0045116; GO:0048471; GO:0051443; GO:0097602 0 0 0 PF03556; Q8K4R9 CHOYP_DLGAP5.1.1 m.15789 sp DLGP5_MOUSE 53.957 139 62 2 785 922 398 535 1.65E-38 159 DLGP5_MOUSE reviewed Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein homolog) (HURP) Dlgap5 Dlg7 Kiaa0008 Mus musculus (Mouse) 808 cell cycle [GO:0007049]; signaling [GO:0023052] GO:0004721; GO:0005634; GO:0005737; GO:0005815; GO:0007049; GO:0023052; GO:0031616 0 0 0 PF03359; Q8SWR3 CHOYP_CPIPJ_CPIJ000143.2.2 m.25122 sp SPR_DROME 23.706 367 263 6 2 357 72 432 1.65E-22 101 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q8TE56 CHOYP_ADAMTS17.1.1 m.14167 sp ATS17_HUMAN 39.516 124 61 7 14 130 447 563 1.65E-10 63.9 ATS17_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) ADAMTS17 Homo sapiens (Human) 1095 0 GO:0004222; GO:0005578; GO:0008270 0 0 0 PF05986;PF01562;PF01421;PF00090; Q8WXX7 CHOYP_LOC100376759.2.2 m.59482 sp AUTS2_HUMAN 32.319 427 196 19 356 720 422 817 1.65E-18 95.5 AUTS2_HUMAN reviewed Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) 1259 innate vocalization behavior [GO:0098582]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H4-K16 acetylation [GO:2000620]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; righting reflex [GO:0060013] GO:0003682; GO:0005634; GO:0045944; GO:0051571; GO:0060013; GO:0098582; GO:2000620 0 0 0 0 Q91Y25 CHOYP_BRAFLDRAFT_118099.3.6 m.19474 sp FAM21_CRIGR 36.341 787 358 30 9 735 13 716 1.65E-77 286 FAM21_CRIGR reviewed WASH complex subunit FAM21 Fam21 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 1317 "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005769; GO:0005829; GO:0005886; GO:0015031; GO:0031901; GO:0042147; GO:0071203 0 0 0 PF15255; Q967D7 CHOYP_LOC100643265.1.2 m.8188 sp TUTL_DROME 32.827 658 410 15 21 661 246 888 1.65E-103 365 TUTL_DROME reviewed Protein turtle tutl CG15427 Drosophila melanogaster (Fruit fly) 1531 adult locomotory behavior [GO:0008344]; axonal defasciculation [GO:0007414]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite self-avoidance [GO:0070593]; flight behavior [GO:0007629]; larval behavior [GO:0030537]; lateral inhibition [GO:0046331]; mechanosensory behavior [GO:0007638]; R7 cell development [GO:0045467]; regulation of dendrite morphogenesis [GO:0048814]; sensory perception of pain [GO:0019233]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007411; GO:0007414; GO:0007629; GO:0007638; GO:0008039; GO:0008344; GO:0016199; GO:0019233; GO:0030537; GO:0045467; GO:0046331; GO:0048814; GO:0070593; GO:0098632 0 0 0 PF00041;PF07679;PF07686; Q96PE7 CHOYP_LOC100232142.1.1 m.19194 sp MCEE_HUMAN 64.539 141 47 1 31 168 26 166 1.65E-62 194 MCEE_HUMAN reviewed "Methylmalonyl-CoA epimerase, mitochondrial (EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)" MCEE Homo sapiens (Human) 176 L-methylmalonyl-CoA metabolic process [GO:0046491]; short-chain fatty acid catabolic process [GO:0019626] GO:0004493; GO:0005759; GO:0019626; GO:0046491; GO:0046872 0 0 0 0 Q96RW7 CHOYP_HMCN1.37.44 m.60555 sp HMCN1_HUMAN 24.87 386 239 17 236 609 3640 3986 1.65E-11 72.8 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BXJ4 CHOYP_C1QT3.3.8 m.21759 sp C1QT3_HUMAN 30.769 117 75 4 45 159 109 221 1.65E-11 63.9 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9CYB0 CHOYP_TRI45.14.23 m.37513 sp TRI13_MOUSE 23.316 193 129 5 41 229 78 255 1.65E-07 55.5 TRI13_MOUSE reviewed E3 ubiquitin-protein ligase TRIM13 (EC 6.3.2.-) (Putative tumor suppressor RFP2) (Ret finger protein 2) (Tripartite motif-containing protein 13) Trim13 Rfp2 Mus musculus (Mouse) 407 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; innate immune response [GO:0045087]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell death [GO:0010942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; response to gamma radiation [GO:0010332] GO:0004842; GO:0004871; GO:0005737; GO:0005789; GO:0008270; GO:0010332; GO:0010942; GO:0016021; GO:0016239; GO:0016874; GO:0030433; GO:0032897; GO:0043123; GO:0043161; GO:0045087; GO:0051092; GO:0051865; GO:0097038; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q9ES28 CHOYP_ARHG7.5.5 m.51202 sp ARHG7_MOUSE 38.197 233 114 9 1 210 635 860 1.65E-30 121 ARHG7_MOUSE reviewed Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR) Arhgef7 Kiaa0142 Pak3bp Mus musculus (Mouse) 862 focal adhesion assembly [GO:0048041]; Golgi organization [GO:0007030]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of protein binding [GO:0032092]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of GTP binding [GO:1904424]; regulation of Rho protein signal transduction [GO:0035023] GO:0000322; GO:0001726; GO:0002244; GO:0005085; GO:0005089; GO:0005829; GO:0005886; GO:0005925; GO:0005938; GO:0007030; GO:0007399; GO:0010763; GO:0019901; GO:0030027; GO:0030032; GO:0032092; GO:0035023; GO:0035556; GO:0043005; GO:0043025; GO:0043065; GO:0043234; GO:0043547; GO:0048041; GO:0060124; GO:1900026; GO:1904424; GO:2000394 0 0 0 PF16523;PF00307;PF00169;PF00621;PF07653; Q9JIW4 CHOYP_BRAFLDRAFT_124950.1.1 m.8140 sp DPOLM_MOUSE 33.658 514 286 9 7 514 31 495 1.65E-101 317 DPOLM_MOUSE reviewed DNA-directed DNA/RNA polymerase mu (Pol Mu) (EC 2.7.7.7) (Terminal transferase) Polm polmu Mus musculus (Mouse) 496 B cell differentiation [GO:0030183]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; somatic hypermutation of immunoglobulin genes [GO:0016446] GO:0003677; GO:0003887; GO:0005634; GO:0006281; GO:0006310; GO:0016446; GO:0030183; GO:0046872 0 0 cd00141; PF14792;PF14791;PF10391;PF14716; Q9N587 CHOYP_ISCW_ISCW003334.1.2 m.39073 sp ACH6_CAEEL 49.315 292 135 2 5 285 207 496 1.65E-79 252 ACH6_CAEEL reviewed Acetylcholine receptor subunit alpha-type unc-63 (Levamisole-resistant protein 7) (Uncoordinated protein 63) unc-63 lev-7 Y110A7A.3 Caenorhabditis elegans 502 "calcium ion import across plasma membrane [GO:0098703]; ion transmembrane transport [GO:0034220]; locomotion [GO:0040011]; neuromuscular synaptic transmission [GO:0007274]; post-embryonic development [GO:0009791]; regulation of locomotion [GO:0040012]; regulation of oviposition [GO:0046662]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005886; GO:0005892; GO:0007271; GO:0007274; GO:0009791; GO:0022848; GO:0030054; GO:0031594; GO:0034220; GO:0035094; GO:0040011; GO:0040012; GO:0045211; GO:0046662; GO:0098703 0 0 0 PF02931;PF02932; Q9NS37 CHOYP_MYS3.2.2 m.62325 sp ZHANG_HUMAN 29.609 179 77 2 102 280 219 348 1.65E-14 76.3 ZHANG_HUMAN reviewed CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) CREBZF ZF Homo sapiens (Human) 354 "negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; response to virus [GO:0009615]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0009615; GO:0042802; GO:0043565; GO:0045814; GO:0045892; GO:0051090 0 0 0 PF00170; A2AVA0 CHOYP_SVEP1.8.8 m.44971 sp SVEP1_MOUSE 33.099 142 68 2 1 115 1115 1256 1.66E-11 65.9 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A3DH97 CHOYP_BRAFLDRAFT_81364.3.3 m.30607 sp RSGI6_CLOTH 33.607 366 233 6 189 552 379 736 1.66E-56 206 RSGI6_CLOTH reviewed "Anti-sigma-I factor RsgI6 (Endo-1,4-beta-xylanase) (EC 3.2.1.8)" rsgI6 Cthe_2119 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 760 xylan catabolic process [GO:0045493] GO:0005886; GO:0016021; GO:0031176; GO:0045493 PATHWAY: Glycan degradation; xylan degradation. {ECO:0000255|PROSITE-ProRule:PRU01096}. 0 0 PF00331;PF12791; A4IF63 CHOYP_LOC100369333.5.32 m.21480 sp TRIM2_BOVIN 22.179 257 182 8 74 314 489 743 1.66E-06 53.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B3EWZ6 CHOYP_LOC580670.4.6 m.19319 sp MLRP2_ACRMI 30.651 783 401 26 1 728 537 1232 1.66E-80 285 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D2GXS7 CHOYP_BRAFLDRAFT_93988.3.3 m.42401 sp TRIM2_AILME 34.524 84 53 2 77 159 625 707 1.66E-08 56.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_HMCN1.30.44 m.53396 sp HMCN1_MOUSE 39.344 244 113 9 72 315 4572 4780 1.66E-41 167 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E0CZ16 CHOYP_LOC100367192.2.2 m.54855 sp KLHL3_MOUSE 36.397 544 339 6 49 591 31 568 1.66E-126 387 KLHL3_MOUSE reviewed Kelch-like protein 3 Klhl3 Mus musculus (Mouse) 587 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0003824; GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O08658 CHOYP_BRAFLDRAFT_122018.1.1 m.21774 sp NUP88_RAT 38.164 697 403 11 133 817 57 737 1.66E-160 488 NUP88_RAT reviewed Nuclear pore complex protein Nup88 (88 kDa nucleoporin) (Nucleoporin Nup84) (Nucleoporin Nup88) Nup88 Nup84 Rattus norvegicus (Rat) 742 mitotic nuclear division [GO:0007067]; mRNA export from nucleus [GO:0006406]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056] GO:0000055; GO:0000056; GO:0005215; GO:0005643; GO:0005654; GO:0006406; GO:0006606; GO:0006611; GO:0007067 0 0 0 PF10168; O15990 CHOYP_LOC101174856.1.1 m.47587 sp KARG_LIOJA 74.126 143 36 1 29 170 205 347 1.66E-70 220 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O73791 CHOYP_CED1.1.29 m.370 sp TIE2_DANRE 34.266 143 58 9 66 188 218 344 1.66E-13 73.2 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O75179 CHOYP_LOC753709.6.44 m.17451 sp ANR17_HUMAN 35.96 495 296 15 35 511 222 713 1.66E-64 231 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_BRAFLDRAFT_205965.35.43 m.59615 sp TRIM3_HUMAN 26.667 105 75 1 169 271 622 726 1.66E-06 52.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O93209 CHOYP_LOC100497926.2.2 m.57492 sp POL_FFV 29.143 175 110 3 226 400 241 401 1.66E-08 61.6 POL_FFV reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Feline foamy virus (FFV) (Feline syncytial virus) 1156 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; P06605 CHOYP_TBA1.2.9 m.9962 sp TBA3_DROME 96.983 232 6 1 1 232 1 231 1.66E-167 472 TBA3_DROME reviewed Tubulin alpha-3 chain alphaTub84D TubA84D CG2512 Drosophila melanogaster (Fruit fly) 450 microtubule-based process [GO:0007017]; mitotic cytokinesis [GO:0000281] GO:0000281; GO:0003924; GO:0005200; GO:0005525; GO:0005811; GO:0005874; GO:0007017; GO:0017022; GO:0048471 0 0 0 PF00091;PF03953; P15127 CHOYP_VKR.1.1 m.56628 sp INSR_RAT 43.213 361 181 8 829 1173 947 1299 1.66E-72 270 INSR_RAT reviewed Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] Insr Rattus norvegicus (Rat) 1383 cerebellum development [GO:0021549]; fat cell differentiation [GO:0045444]; glucose homeostasis [GO:0042593]; hippocampus development [GO:0021766]; insulin receptor signaling pathway [GO:0008286]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transporter activity [GO:0032410]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of glycoprotein biosynthetic process [GO:0010560]; positive regulation of phosphorylation [GO:0042327]; protein autophosphorylation [GO:0046777]; protein heterotetramerization [GO:0051290]; protein phosphorylation [GO:0006468]; regulation of hydrogen peroxide metabolic process [GO:0010310]; response to activity [GO:0014823]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to insulin [GO:0032868]; response to manganese ion [GO:0010042]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]; response to tumor necrosis factor [GO:0034612]; response to vitamin D [GO:0033280] GO:0001933; GO:0004672; GO:0004713; GO:0005009; GO:0005524; GO:0005634; GO:0005768; GO:0005829; GO:0005886; GO:0006468; GO:0008286; GO:0009725; GO:0009749; GO:0010042; GO:0010310; GO:0010560; GO:0010629; GO:0014823; GO:0016021; GO:0018108; GO:0019901; GO:0019903; GO:0019904; GO:0021549; GO:0021766; GO:0031405; GO:0031667; GO:0032355; GO:0032403; GO:0032410; GO:0032868; GO:0033280; GO:0033574; GO:0034612; GO:0042327; GO:0042593; GO:0043025; GO:0043231; GO:0043423; GO:0043559; GO:0043560; GO:0045202; GO:0045444; GO:0045471; GO:0046777; GO:0051290; GO:0051384 0 0 0 PF00041;PF00757;PF07714;PF01030; P16157 CHOYP_AFUA_1G01020.46.50 m.65366 sp ANK1_HUMAN 32.914 556 326 2 1 509 231 786 1.66E-71 251 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20825 CHOYP_contig_009642 m.11197 sp POL2_DROME 38.114 509 293 7 190 690 129 623 1.66E-99 337 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P62755 CHOYP_LOC100367243.1.1 m.36882 sp RS6_RAT 84.127 126 20 0 9 134 9 134 1.66E-76 232 RS6_RAT reviewed 40S ribosomal protein S6 Rps6 Rattus norvegicus (Rat) 249 cellular response to ethanol [GO:0071361]; glucose homeostasis [GO:0042593]; negative regulation of bicellular tight junction assembly [GO:1903347]; response to insulin [GO:0032868]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0000028; GO:0003729; GO:0003735; GO:0006364; GO:0006412; GO:0022627; GO:0032868; GO:0042593; GO:0071361; GO:1903347 0 0 0 PF01092; P84082 CHOYP_ARF2.1.3 m.10738 sp ARF2_RAT 92.265 181 14 0 1 181 1 181 1.66E-124 350 ARF2_RAT reviewed ADP-ribosylation factor 2 Arf2 Rattus norvegicus (Rat) 181 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; P84082 CHOYP_ARF2.3.3 m.66404 sp ARF2_RAT 92.265 181 14 0 1 181 1 181 1.66E-124 350 ARF2_RAT reviewed ADP-ribosylation factor 2 Arf2 Rattus norvegicus (Rat) 181 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q00651 CHOYP_BRAFLDRAFT_125595.1.1 m.39606 sp ITA4_MOUSE 25.069 1089 687 41 12 1049 26 1036 1.66E-60 229 ITA4_MOUSE reviewed Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d) Itga4 Mus musculus (Mouse) 1039 blood vessel remodeling [GO:0001974]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-matrix adhesion involved in ameboidal cell migration [GO:0003366]; cell migration [GO:0016477]; chorio-allantoic fusion [GO:0060710]; face development [GO:0060324]; heart development [GO:0007507]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; mesenchyme development [GO:0060485]; negative regulation of protein homodimerization activity [GO:0090074]; receptor clustering [GO:0043113]; single organismal cell-cell adhesion [GO:0016337]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell migration [GO:0072678]; visceral serous pericardium development [GO:0061032] GO:0001968; GO:0001974; GO:0003366; GO:0005886; GO:0005911; GO:0005925; GO:0007155; GO:0007157; GO:0007159; GO:0007160; GO:0007229; GO:0007507; GO:0009897; GO:0009986; GO:0016020; GO:0016337; GO:0016477; GO:0034113; GO:0034446; GO:0034669; GO:0043113; GO:0046872; GO:0050839; GO:0050901; GO:0060324; GO:0060485; GO:0060710; GO:0061032; GO:0070062; GO:0072678; GO:0090074 0 0 0 PF01839;PF08441; Q08289 CHOYP_CACNB2.1.1 m.10659 sp CACB2_HUMAN 59.524 420 149 7 29 439 68 475 1.66E-167 494 CACB2_HUMAN reviewed Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) CACNB2 CACNLB2 MYSB Homo sapiens (Human) 660 calcium ion import [GO:0070509]; cardiac conduction [GO:0061337]; chemical synaptic transmission [GO:0007268]; establishment of protein localization to plasma membrane [GO:0090002]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; neuromuscular junction development [GO:0007528]; positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1904879]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of high voltage-gated calcium channel activity [GO:1901843]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of voltage-gated calcium channel activity [GO:1901385]; visual perception [GO:0007601] GO:0005245; GO:0005246; GO:0005262; GO:0005886; GO:0005887; GO:0005891; GO:0007268; GO:0007528; GO:0007601; GO:0051015; GO:0051928; GO:0061337; GO:0070509; GO:0086045; GO:0086091; GO:0090002; GO:0098912; GO:1901385; GO:1901843; GO:1904879; GO:1990454 0 0 0 PF00625;PF12052; Q09225 CHOYP_LOC585706.1.1 m.12556 sp NRF6_CAEEL 26.043 791 462 22 153 892 81 799 1.66E-75 266 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q09738 CHOYP_UBP22.1.3 m.4297 sp UBP8_SCHPO 25.625 320 200 13 607 918 146 435 1.66E-19 95.9 UBP8_SCHPO reviewed Probable ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) ubp8 SPAC13A11.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 449 histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; protein deubiquitination [GO:0016579]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000124; GO:0004843; GO:0005634; GO:0005654; GO:0006357; GO:0006511; GO:0008270; GO:0016579; GO:0035616 0 0 0 PF00443;PF02148; Q0P4F7 CHOYP_LOC100368525.1.1 m.62481 sp ACSF2_DANRE 46.884 337 177 2 45 380 50 385 1.66E-102 319 ACSF2_DANRE reviewed "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) 606 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005739; GO:0006631; GO:0016874 0 0 0 PF00501;PF13193; Q0VA64 CHOYP_DERE_GG18759.1.1 m.28627 sp UBP16_XENTR 33.75 80 50 2 2 79 729 807 1.66E-10 61.2 UBP16_XENTR reviewed Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) usp16 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 864 "cell division [GO:0051301]; histone deubiquitination [GO:0016578]; histone H2A K63-linked deubiquitination [GO:0070537]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein homotetramerization [GO:0051289]; regulation of cell cycle [GO:0051726]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0003713; GO:0004197; GO:0004843; GO:0005634; GO:0006351; GO:0006511; GO:0007067; GO:0008270; GO:0016578; GO:0042393; GO:0043130; GO:0045893; GO:0051289; GO:0051301; GO:0051726; GO:0070537 0 0 0 PF00443;PF02148; Q1MTD4 CHOYP_MCES.1.2 m.15349 sp CR19A_DANRE 48.052 77 28 2 4 68 143 219 1.66E-12 65.5 CR19A_DANRE reviewed Uncharacterized protein C18orf19 homolog A si:ch211-105d11.2 Danio rerio (Zebrafish) (Brachydanio rerio) 242 0 GO:0016021 0 0 0 PF06916; Q2KI24 CHOYP_STK31.1.1 m.16298 sp MTHSD_BOVIN 62.151 251 95 0 23 273 7 257 1.66E-115 342 MTHSD_BOVIN reviewed Methenyltetrahydrofolate synthase domain-containing protein MTHFSD Bos taurus (Bovine) 380 0 GO:0000166; GO:0044822 0 0 0 PF01812;PF00076; Q2KI56 CHOYP_LOC100378691.1.2 m.2039 sp CSN7B_BOVIN 55.14 214 92 2 1 210 49 262 1.66E-77 236 CSN7B_BOVIN reviewed COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) COPS7B Bos taurus (Bovine) 264 cullin deneddylation [GO:0010388] GO:0005737; GO:0008180; GO:0010388 0 0 0 PF01399; Q3SZ48 CHOYP_LOC100368816.2.2 m.50335 sp TM55A_BOVIN 47.718 241 106 4 28 248 10 250 1.66E-70 220 TM55A_BOVIN reviewed "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)" TMEM55A Bos taurus (Bovine) 257 phosphatidylinositol dephosphorylation [GO:0046856] GO:0005765; GO:0016021; GO:0031902; GO:0034597; GO:0046856 0 0 0 PF09788; Q460N5 CHOYP_LOC100928016.1.6 m.34742 sp PAR14_HUMAN 29.146 398 251 10 794 1179 801 1179 1.66E-37 157 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4PM12 CHOYP_RL36.3.8 m.23015 sp RL36_IXOSC 63.636 88 30 1 24 109 23 110 1.66E-31 112 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q503I2 CHOYP_LOC100121684.2.3 m.65049 sp TRI13_DANRE 20.502 239 171 5 46 284 51 270 1.66E-06 53.1 TRI13_DANRE reviewed Tripartite motif-containing 13 trim13 zgc:110578 Danio rerio (Zebrafish) (Brachydanio rerio) 404 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q589R5 CHOYP_LOC100879250.1.1 m.24381 sp TPIS_ORYLA 65.462 249 84 1 1 249 1 247 1.66E-122 351 TPIS_ORYLA reviewed Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase) tpi1 tpi Oryzias latipes (Japanese rice fish) (Japanese killifish) 248 gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; pentose-phosphate shunt [GO:0006098] GO:0004807; GO:0006094; GO:0006096; GO:0006098 0 0 cd00311; PF00121; Q5I2E5 CHOYP_MFAP4.1.3 m.42579 sp FCN2_BOVIN 50.35 143 64 3 14 156 160 295 1.66E-36 132 FCN2_BOVIN reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) 329 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0046872 0 0 0 PF01391;PF00147; Q5M9G3 CHOYP_LOC100212669.1.1 m.22211 sp CAPR1_RAT 39.823 226 125 7 22 244 50 267 1.66E-35 142 CAPR1_RAT reviewed Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105) Caprin1 Gpiap1 Rng105 Rattus norvegicus (Rat) 707 negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003] GO:0000932; GO:0003723; GO:0005829; GO:0010494; GO:0017148; GO:0030425; GO:0050775; GO:0061003 0 0 0 PF12287; Q5R7X9 CHOYP_LOC100370910.1.1 m.13897 sp RAD1_PONAB 69.858 282 84 1 1 281 1 282 1.66E-147 417 RAD1_PONAB reviewed Cell cycle checkpoint protein RAD1 (EC 3.1.11.2) (DNA repair exonuclease rad1 homolog) RAD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 282 cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; meiotic recombination checkpoint [GO:0051598]; substantia nigra development [GO:0021762] GO:0000077; GO:0005654; GO:0005694; GO:0006281; GO:0008408; GO:0008853; GO:0021762; GO:0051598; GO:0071479 0 0 0 PF02144; Q5RDC3 CHOYP_LOC100563309.2.2 m.7449 sp TF3C2_PONAB 26.617 665 413 20 434 1059 238 866 1.66E-45 181 TF3C2_PONAB reviewed General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC subunit beta) GTF3C2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 911 "transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351 0 0 0 PF00400; Q5XGW6 CHOYP_CHM4B.1.1 m.19057 sp CHM4B_XENLA 67.556 225 69 3 42 266 1 221 1.66E-87 262 CHM4B_XENLA reviewed Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) chmp4b Xenopus laevis (African clawed frog) 222 exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; nuclear envelope reassembly [GO:0031468]; protein transport [GO:0015031]; vacuolar transport [GO:0007034] GO:0000281; GO:0000815; GO:0005635; GO:0005829; GO:0007034; GO:0010458; GO:0015031; GO:0030496; GO:0031468; GO:0031902; GO:0090148 0 0 0 PF03357; Q61555 CHOYP_LOC100374579.1.3 m.8774 sp FBN2_MOUSE 33.397 521 285 19 1 480 1066 1565 1.66E-58 214 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q63HN8 CHOYP_BRAFLDRAFT_106560.12.14 m.49280 sp RN213_HUMAN 21.525 446 292 14 170 598 4760 5164 1.66E-06 55.5 RN213_HUMAN reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) 5207 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:21799892}. 0 0 PF00097; Q6DFJ9 CHOYP_CCNJ.1.1 m.10581 sp CCNJ_XENLA 41.961 255 145 2 1 253 1 254 1.66E-62 205 CCNJ_XENLA reviewed Cyclin-J ccnj Xenopus laevis (African clawed frog) 384 0 GO:0005634 0 0 0 PF02984;PF00134; Q6INE8 CHOYP_VMP1.1.1 m.34831 sp VMP1_XENLA 64.894 376 126 2 29 404 30 399 1.66E-173 493 VMP1_XENLA reviewed Vacuole membrane protein 1 (Transmembrane protein 49) vmp1 tmem49 Xenopus laevis (African clawed frog) 406 0 GO:0005774; GO:0005783; GO:0005886; GO:0016021; GO:0033116 0 0 0 PF09335; Q6PFY8 CHOYP_LOC100378898.6.10 m.48244 sp TRI45_MOUSE 29.412 204 127 6 2 199 129 321 1.66E-12 72 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6QNK2 CHOYP_GPR133.1.1 m.9337 sp AGRD1_HUMAN 33.333 168 104 4 10 171 680 845 1.66E-17 84.3 AGRD1_HUMAN reviewed Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) ADGRD1 GPR133 PGR25 Homo sapiens (Human) 874 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579] GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0010579; GO:0016021 0 0 0 PF00002;PF01825; Q7L5D6 CHOYP_LOC100741726.1.1 m.9384 sp GET4_HUMAN 53.398 309 140 3 16 323 18 323 1.66E-119 350 GET4_HUMAN reviewed Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35) GET4 C7orf20 CEE TRC35 CGI-20 Homo sapiens (Human) 327 cytoplasmic sequestering of protein [GO:0051220]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; transport [GO:0006810] GO:0005737; GO:0005829; GO:0006810; GO:0051087; GO:0051220; GO:0071816; GO:0071818; GO:1904378 0 0 0 PF04190; Q7SIG4 CHOYP_DFPA.1.1 m.29402 sp DFPA_LOLVU 59.935 307 122 1 12 317 3 309 1.66E-144 412 DFPA_LOLVU reviewed Diisopropyl-fluorophosphatase (DFPase) (EC 3.1.8.2) 0 Loligo vulgaris (Common European squid) 314 0 GO:0005509; GO:0047862 0 0 0 PF08450; Q7TNF8 CHOYP_BZRAP1.2.2 m.44231 sp RIMB1_MOUSE 31.744 923 507 25 26 892 131 986 1.66E-112 383 RIMB1_MOUSE reviewed Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) Tspoap1 Bzrap1 Kiaa0612 Rbp1 Mus musculus (Mouse) 1846 0 GO:0005737; GO:0005739; GO:0030156 0 0 0 PF07653;PF14604; Q8BH27 CHOYP_MEGF9.1.1 m.43747 sp MEGF9_MOUSE 28.261 276 136 10 296 514 318 588 1.66E-20 98.6 MEGF9_MOUSE reviewed Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5) Megf9 Egfl5 Kiaa0818 Mus musculus (Mouse) 600 0 GO:0005604; GO:0016021 0 0 0 PF00053; Q8IYG6 CHOYP_BRAFLDRAFT_119045.2.2 m.37510 sp LRC56_HUMAN 38.71 93 48 3 72 156 139 230 1.66E-08 58.2 LRC56_HUMAN reviewed Leucine-rich repeat-containing protein 56 LRRC56 Homo sapiens (Human) 542 0 0 0 0 0 0 Q8N126 CHOYP_HSPG2.4.4 m.22597 sp CADM3_HUMAN 32.877 146 81 7 12 149 97 233 1.66E-08 56.2 CADM3_HUMAN reviewed Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1) CADM3 IGSF4B NECL1 SYNCAM3 TSLL1 UNQ225/PRO258 Homo sapiens (Human) 398 adherens junction organization [GO:0034332]; cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein localization [GO:0008104] GO:0004872; GO:0005102; GO:0005886; GO:0005887; GO:0005911; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0008104; GO:0034332; GO:0042803; GO:0050839 0 0 0 PF08205;PF07679; Q8N3A8 CHOYP_PARP8.1.1 m.55346 sp PARP8_HUMAN 37.603 851 425 20 1 751 3 847 1.66E-166 504 PARP8_HUMAN reviewed Poly [ADP-ribose] polymerase 8 (PARP-8) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) PARP8 Homo sapiens (Human) 854 0 GO:0003950; GO:0005622 0 0 0 PF00644; Q8TER0 CHOYP_LOC580251.4.5 m.49211 sp SNED1_HUMAN 31.452 124 84 1 97 220 680 802 1.66E-15 82 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q9DFQ7 CHOYP_RL24.3.9 m.18600 sp RL24_GILMI 69.231 117 29 2 2 114 43 156 1.66E-41 138 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9FWW9 CHOYP_BRAFLDRAFT_278918.2.5 m.16457 sp GSXL2_ARATH 36.715 414 235 10 3 395 11 418 1.66E-75 245 GSXL2_ARATH reviewed Flavin-containing monooxygenase FMO GS-OX-like 2 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 2) At1g12200 T28K15.7 Arabidopsis thaliana (Mouse-ear cress) 465 defense response to fungus [GO:0050832]; oxidation-reduction process [GO:0055114] GO:0004497; GO:0004499; GO:0050660; GO:0050661; GO:0050832; GO:0055114 0 0 0 PF00743; Q9NUV9 CHOYP_LOC100616953.3.4 m.56543 sp GIMA4_HUMAN 34.322 236 151 2 42 277 32 263 1.66E-40 147 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9VCA8 CHOYP_TVAG_313830.1.4 m.32667 sp ANKHM_DROME 31.979 566 292 19 889 1432 552 1046 1.66E-49 198 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9WV76 CHOYP_AP4B1.1.1 m.12780 sp AP4B1_MOUSE 42.748 262 150 0 25 286 30 291 1.66E-67 226 AP4B1_MOUSE reviewed AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) Ap4b1 Mus musculus (Mouse) 738 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005802; GO:0005905; GO:0006886; GO:0008565; GO:0016192; GO:0030131 0 0 0 PF01602;PF09066; Q9Y345 CHOYP_LOC100375514.2.6 m.12927 sp SC6A5_HUMAN 54.768 409 173 3 37 444 181 578 1.66E-156 465 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; A1A600 CHOYP_LOC100377113.3.3 m.37326 sp EFC4A_DANRE 39.222 334 194 2 11 344 27 351 1.67E-69 227 EFC4A_DANRE reviewed EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated channel regulator 2B) cracr2b efcab4a zgc:158448 Danio rerio (Zebrafish) (Brachydanio rerio) 390 0 GO:0005509 0 0 0 PF13499; A6BM72 CHOYP_MEG10.64.91 m.50501 sp MEG11_HUMAN 38.788 330 174 15 4 332 467 769 1.67E-48 177 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; B3EWZ6 CHOYP_NEMVEDRAFT_V1G239043.3.6 m.5896 sp MLRP2_ACRMI 31.121 1070 540 38 592 1561 1 973 1.67E-112 400 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D2GXS7 CHOYP_ZF_BBOX_RING_-1.2.10 m.21637 sp TRIM2_AILME 26.563 192 124 6 280 468 544 721 1.67E-08 60.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E1BD44 CHOYP_contig_020569 m.23745 sp BATF_BOVIN 43.421 76 39 2 79 150 28 103 1.67E-08 53.5 BATF_BOVIN reviewed Basic leucine zipper transcriptional factor ATF-like (B-cell-activating transcription factor) (B-ATF) BATF Bos taurus (Bovine) 125 "cellular response to DNA damage stimulus [GO:0006974]; cytokine production [GO:0001816]; defense response to protozoan [GO:0042832]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; hematopoietic stem cell differentiation [GO:0060218]; isotype switching [GO:0045190]; lymphoid progenitor cell differentiation [GO:0002320]; myeloid dendritic cell differentiation [GO:0043011]; T-helper 17 cell differentiation [GO:0072539]; T-helper 17 cell lineage commitment [GO:0072540]; T-helper 2 cell differentiation [GO:0045064]" GO:0000978; GO:0000982; GO:0001077; GO:0001816; GO:0002320; GO:0003700; GO:0005634; GO:0005737; GO:0006974; GO:0030330; GO:0042832; GO:0043011; GO:0043565; GO:0045064; GO:0045190; GO:0060218; GO:0072539; GO:0072540 0 0 0 PF00170; F1NHE9 CHOYP_AGAP_AGAP001281.1.1 m.18034 sp KCJ12_CHICK 42.236 322 182 3 14 333 40 359 1.67E-87 274 KCJ12_CHICK reviewed "ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (Potassium channel, inwardly rectifying subfamily J member 12)" KCNJ12 Gallus gallus (Chicken) 429 potassium ion import [GO:0010107]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289] GO:0005242; GO:0005887; GO:0006813; GO:0010107; GO:0031224; GO:0051289 0 0 0 PF01007;PF08466; F6QEU4 CHOYP_LOC100370725.3.5 m.47079 sp LIN41_XENTR 26.027 146 79 6 7 124 141 285 1.67E-06 49.7 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; F7E235 CHOYP_LOC100377010.5.16 m.32739 sp FAXC_XENTR 35.821 134 73 3 1 126 127 255 1.67E-21 91.3 FAXC_XENTR reviewed Failed axon connections homolog faxc Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 406 0 GO:0016021 0 0 0 PF17171;PF17172; O01382 CHOYP_LOC100680489.1.1 m.25692 sp DRICE_DROME 28.205 273 165 8 51 320 84 328 1.67E-29 118 DRICE_DROME reviewed Caspase (EC 3.4.22.-) (drICE) [Cleaved into: Caspase subunit p21; Caspase subunit p12] Drice ICE CG7788 Drosophila melanogaster (Fruit fly) 339 apoptotic process [GO:0006915]; neuron remodeling [GO:0016322]; nurse cell apoptotic process [GO:0045476]; positive regulation of compound eye retinal cell programmed cell death [GO:0046672]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; programmed cell death [GO:0012501]; programmed cell death involved in cell development [GO:0010623]; regulation of retinal cell programmed cell death [GO:0046668]; response to X-ray [GO:0010165]; salivary gland histolysis [GO:0035070]; spermatid differentiation [GO:0048515]; sterol regulatory element binding protein cleavage [GO:0035103] GO:0004197; GO:0005737; GO:0006915; GO:0010165; GO:0010623; GO:0012501; GO:0016322; GO:0035070; GO:0035103; GO:0045476; GO:0046668; GO:0046672; GO:0048515; GO:0097153; GO:0097200; GO:1990525; GO:2001269 0 0 0 0 O08740 CHOYP_ISCW_ISCW008174.2.2 m.16165 sp RPB11_MOUSE 80 115 23 0 1 115 1 115 1.67E-66 199 RPB11_MOUSE reviewed DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (DNA-directed RNA polymerase II subunit J) (RNA polymerase II 13.3 kDa subunit) (RPB14) Polr2j Rpo2-4 Mus musculus (Mouse) 117 piRNA metabolic process [GO:0034587]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0006366; GO:0030275; GO:0034587 0 0 0 0 O14495 CHOYP_PPAP2B.1.1 m.52021 sp PLPP3_HUMAN 31.646 237 138 8 46 266 49 277 1.67E-30 119 PLPP3_HUMAN reviewed Phospholipid phosphatase 3 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) PLPP3 LPP3 PPAP2B Homo sapiens (Human) 311 Bergmann glial cell differentiation [GO:0060020]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion [GO:0044329]; canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration [GO:0044328]; canonical Wnt signaling pathway involved in positive regulation of wound healing [GO:0044330]; gastrulation with mouth forming second [GO:0001702]; germ cell migration [GO:0008354]; homotypic cell-cell adhesion [GO:0034109]; lipid metabolic process [GO:0006629]; negative regulation of protein phosphorylation [GO:0001933]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein stabilization [GO:0050821]; regulation of sphingolipid mediated signaling pathway [GO:1902068]; regulation of Wnt signaling pathway [GO:0030111]; sphingolipid biosynthetic process [GO:0030148] GO:0001568; GO:0001702; GO:0001933; GO:0004721; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0005912; GO:0006629; GO:0006644; GO:0008195; GO:0008354; GO:0016020; GO:0030111; GO:0030148; GO:0034109; GO:0042392; GO:0042577; GO:0044328; GO:0044329; GO:0044330; GO:0046839; GO:0050731; GO:0050821; GO:0051091; GO:0060020; GO:0070062; GO:1902068 0 0 0 PF01569; O31463 CHOYP_BRAFLDRAFT_114091.2.3 m.31473 sp HMT_BACSU 44.041 193 104 3 36 227 117 306 1.67E-49 167 HMT_BACSU reviewed Homocysteine S-methyltransferase YbgG (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase) ybgG BSU02410 Bacillus subtilis (strain 168) 315 methionine biosynthetic process [GO:0009086] GO:0008168; GO:0009086; GO:0046872 0 0 0 PF02574; O35375 CHOYP_LOC100552730.1.1 m.18699 sp NRP2_MOUSE 28.522 291 168 14 99 366 45 318 1.67E-20 97.8 NRP2_MOUSE reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) Nrp2 Mus musculus (Mouse) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; heart development [GO:0007507]; negative chemotaxis [GO:0050919]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649] GO:0001525; GO:0001755; GO:0001764; GO:0005021; GO:0005886; GO:0007411; GO:0007507; GO:0008201; GO:0016021; GO:0017154; GO:0021612; GO:0021649; GO:0021675; GO:0021828; GO:0030424; GO:0036486; GO:0046872; GO:0048846; GO:0050919; GO:0061549; GO:0061551; GO:0097374; GO:0097490; GO:0097491; GO:1901166; GO:1902285; GO:1903375; GO:1904835 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O75063 CHOYP_XYLK.1.1 m.26585 sp XYLK_HUMAN 57.143 343 145 2 83 424 62 403 1.67E-145 423 XYLK_HUMAN reviewed Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Xylose kinase) FAM20B KIAA0475 Homo sapiens (Human) 409 positive regulation of protein targeting to mitochondrion [GO:1903955] GO:0000139; GO:0005524; GO:0005654; GO:0005794; GO:0016021; GO:0016301; GO:0016773; GO:0046872; GO:1903955 0 0 0 PF06702; P10079 CHOYP_LOC663838.1.2 m.40549 sp FBP1_STRPU 42.075 530 286 12 1907 2422 373 895 1.67E-107 375 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11714 CHOYP_LOC101157767.1.1 m.38502 sp CP2D9_MOUSE 30.804 448 280 9 34 465 63 496 1.67E-61 211 CP2D9_MOUSE reviewed Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (Cytochrome P450-16-alpha) (Cytochrome P450CA) (Testosterone 16-alpha hydroxylase) Cyp2d9 Cyp2d-9 Mus musculus (Mouse) 504 arachidonic acid metabolic process [GO:0019369] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019369; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P18433 CHOYP_LOC100208822.1.2 m.33957 sp PTPRA_HUMAN 28.507 670 428 20 41 677 133 784 1.67E-72 253 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P24733 CHOYP_MYS.2.7 m.2070 sp MYS_ARGIR 59.055 254 104 0 2 255 1197 1450 1.67E-82 273 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P41950 CHOYP_BRAFLDRAFT_92365.2.3 m.50240 sp DEX1_CAEEL 26.506 166 103 7 51 214 132 280 1.67E-07 54.7 DEX1_CAEEL reviewed Dendrite extension defective protein 1 dex-1 D1044.2 Caenorhabditis elegans 1090 amphid sensory organ dendrite retrograde extension [GO:0003391]; cell-matrix adhesion [GO:0007160] GO:0003391; GO:0005509; GO:0005576; GO:0007160; GO:0016021; GO:0030425; GO:0032590 0 0 0 PF12947;PF06119; P46209 CHOYP_LOC100790249.1.1 m.41179 sp USF_AQUPY 35.385 195 108 7 32 215 27 214 1.67E-26 105 USF_AQUPY reviewed Protein usf usf Aquifex pyrophilus 231 0 GO:0016787 0 0 0 PF01738; P46791 CHOYP_RS2.8.10 m.48098 sp RS2_CRIGR 85.393 89 13 0 1 89 50 138 1.67E-51 164 RS2_CRIGR reviewed 40S ribosomal protein S2 (Fragment) RPS2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 202 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; P48725 CHOYP_LOC100186299.5.6 m.32771 sp PCNT_MOUSE 44.118 102 49 3 5 101 2666 2764 1.67E-19 85.1 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; P49013 CHOYP_LOC100184047.2.3 m.11864 sp FBP3_STRPU 38.462 143 70 6 1 137 205 335 1.67E-16 81.3 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P54922 CHOYP_BRAFLDRAFT_212086.8.11 m.57242 sp ADPRH_HUMAN 54.802 354 153 4 109 460 3 351 1.67E-130 384 ADPRH_HUMAN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Homo sapiens (Human) 357 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; P62243 CHOYP_RS8.2.14 m.14440 sp RS8_RAT 80.531 113 22 0 1 113 1 113 1.67E-62 192 RS8_RAT reviewed 40S ribosomal protein S8 Rps8 Rattus norvegicus (Rat) 208 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000462; GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0030529 0 0 0 PF01201; Q01177 CHOYP_LOC100548534.1.1 m.26485 sp PLMN_RAT 39.48 423 181 14 2 378 168 561 1.67E-81 268 PLMN_RAT reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Rattus norvegicus (Rat) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; proteolysis involved in cellular protein catabolic process [GO:0051603]; tissue regeneration [GO:0042246]; tissue remodeling [GO:0048771]; trophoblast giant cell differentiation [GO:0060707] GO:0004175; GO:0004252; GO:0005576; GO:0005886; GO:0007596; GO:0019897; GO:0042246; GO:0042730; GO:0043231; GO:0045445; GO:0046716; GO:0048771; GO:0051603; GO:0060707; GO:0060716; GO:0071674 0 0 cd00190; PF00051;PF00024;PF00089; Q01617 CHOYP_CPIPJ_CPIJ012174.1.1 m.41536 sp CPO_DROME 67.836 171 43 6 12 175 440 605 1.67E-61 204 CPO_DROME reviewed Protein couch potato cpo CG43738 Drosophila melanogaster (Fruit fly) 606 chemical synaptic transmission [GO:0007268]; dormancy process [GO:0022611]; multicellular organism development [GO:0007275]; olfactory behavior [GO:0042048]; regulation of hemocyte proliferation [GO:0035206] GO:0000166; GO:0003729; GO:0005634; GO:0007268; GO:0007275; GO:0022611; GO:0035206; GO:0042048 0 0 0 PF00076; Q0Q028 CHOYP_AGAP_AGAP005170.2.2 m.29292 sp DFP3_ANTMY 33.52 179 102 5 1 179 2 163 1.67E-17 82 DFP3_ANTMY reviewed Putative defense protein 3 (DFP-3) 0 Antheraea mylitta (Tasar silkworm) 163 defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087] GO:0005576; GO:0042742; GO:0042832; GO:0045087 0 0 cd08544; PF02014; Q0VGY8 CHOYP_AAEL_AAEL014741.2.2 m.46667 sp TANC1_MOUSE 39.815 108 65 0 1 108 1112 1219 1.67E-19 85.5 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q1RMS8 CHOYP_LOC101061133.1.1 m.2237 sp FBX25_BOVIN 31.694 366 203 7 1 330 1 355 1.67E-48 169 FBX25_BOVIN reviewed F-box only protein 25 FBXO25 Bos taurus (Bovine) 357 protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004842; GO:0005634; GO:0006511; GO:0016567; GO:0019005 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q40588 CHOYP_LOC100376857.2.7 m.38404 sp ASO_TOBAC 26.555 595 353 21 108 691 45 566 1.67E-48 184 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q4PMB3 CHOYP_RS4.3.11 m.15465 sp RS4_IXOSC 80 230 46 0 19 248 3 232 1.67E-133 385 RS4_IXOSC reviewed 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) 262 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q4ZJM9 CHOYP_C1QRF.1.3 m.3704 sp C1QL4_MOUSE 34.188 117 72 2 156 270 110 223 1.67E-09 60.5 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q55FI1 CHOYP_LOC656992.3.3 m.42649 sp GABT_DICDI 52.569 253 117 1 2 254 242 491 1.67E-91 281 GABT_DICDI reviewed 4-aminobutyrate aminotransferase (EC 2.6.1.19) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) gabT DDB_G0268104 Dictyostelium discoideum (Slime mold) 495 gamma-aminobutyric acid catabolic process [GO:0009450] GO:0003867; GO:0005739; GO:0009450; GO:0030170; GO:0032144; GO:0042802; GO:0042803 0 0 cd00610; PF00202; Q5ZM55 CHOYP_LOC100363271.1.1 m.21155 sp FEM1B_CHICK 47.258 383 199 3 1 381 220 601 1.67E-110 342 FEM1B_CHICK reviewed Protein fem-1 homolog B (FEM1b) (FEM1-beta) FEM1B RCJMB04_3b14 Gallus gallus (Chicken) 627 apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001] GO:0005634; GO:0005737; GO:0006915; GO:0016567; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00023;PF12796; Q60738 CHOYP_ORC4.1.1 m.18902 sp ZNT1_MOUSE 40.94 447 177 10 10 380 10 445 1.67E-97 303 ZNT1_MOUSE reviewed Zinc transporter 1 (ZnT-1) (Solute carrier family 30 member 1) Slc30a1 Znt1 Mus musculus (Mouse) 503 cadmium ion transmembrane transport [GO:0070574]; calcium ion import [GO:0070509]; cellular calcium ion homeostasis [GO:0006874]; cellular zinc ion homeostasis [GO:0006882]; detoxification of cadmium ion [GO:0071585]; in utero embryonic development [GO:0001701]; negative regulation of calcium ion import [GO:0090281]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of zinc ion transmembrane import [GO:0071584]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; zinc II ion transport [GO:0006829] GO:0001701; GO:0005385; GO:0005737; GO:0005783; GO:0005794; GO:0005886; GO:0006829; GO:0006874; GO:0006882; GO:0010043; GO:0016021; GO:0019855; GO:0030315; GO:0031965; GO:0046929; GO:0061088; GO:0070509; GO:0070574; GO:0071584; GO:0071585; GO:0090281 0 0 0 PF01545; Q60HD2 CHOYP_ATLA1.3.4 m.53863 sp ATLA1_MACFA 42.462 398 218 6 2 395 55 445 1.67E-106 329 ATLA1_MACFA reviewed Atlastin-1 (EC 3.6.5.-) ATL1 QflA-10403 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; protein homooligomerization [GO:0051260] GO:0000137; GO:0000139; GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0005794; GO:0007029; GO:0007409; GO:0016021; GO:0030424; GO:0042802; GO:0051260 0 0 0 PF02263; Q62656 CHOYP_LOC100208023.5.8 m.43024 sp PTPRZ_RAT 39.474 266 130 8 14 252 1716 1977 1.67E-53 189 PTPRZ_RAT reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (3F8 chondroitin sulfate proteoglycan) (3H1 keratan sulfate proteoglycan) (Phosphacan) Ptprz1 Ptprz Ptpz Rattus norvegicus (Rat) 2316 axonal fasciculation [GO:0007413]; brain development [GO:0007420]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; neuron development [GO:0048666]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; protein dephosphorylation [GO:0006470]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0004725; GO:0005615; GO:0005737; GO:0006470; GO:0007413; GO:0007420; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0010976; GO:0016020; GO:0016021; GO:0016791; GO:0017134; GO:0021766; GO:0030027; GO:0030175; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048666; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; Q65YR7 CHOYP_CPIB.2.3 m.44557 sp CYTA2_DICDI 51.136 88 35 3 39 124 14 95 1.67E-19 79.7 CYTA2_DICDI reviewed Cystatin-A2 cpiB DDB_G0280439 Dictyostelium discoideum (Slime mold) 95 proteolysis [GO:0006508] GO:0004869; GO:0005829; GO:0006508 0 0 0 PF00031; Q6GQ53 CHOYP_LOC100802586.1.1 m.11434 sp PUSL1_XENLA 25.392 319 185 13 16 324 8 283 1.67E-15 80.1 PUSL1_XENLA reviewed tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1) pusl1 Xenopus laevis (African clawed frog) 298 pseudouridine synthesis [GO:0001522]; tRNA processing [GO:0008033] GO:0001522; GO:0003723; GO:0008033; GO:0009982 0 0 0 PF01416; Q6P0I8 CHOYP_LOC100369488.1.1 m.10559 sp EXOS6_DANRE 45.725 269 139 4 1 266 1 265 1.67E-82 251 EXOS6_DANRE reviewed Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) exosc6 mtr3 Danio rerio (Zebrafish) (Brachydanio rerio) 271 "nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; rRNA 3'-end processing [GO:0031125]; rRNA catabolic process [GO:0016075]; U4 snRNA 3'-end processing [GO:0034475]" GO:0000176; GO:0000177; GO:0000178; GO:0003723; GO:0005730; GO:0016075; GO:0031125; GO:0034427; GO:0034475; GO:0071028; GO:0071051 0 0 0 PF01138; Q6R5N8 CHOYP_TLR13.2.5 m.31584 sp TLR13_MOUSE 27.16 648 367 22 35 667 378 935 1.67E-33 141 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q6ZN84 CHOYP_LOC100373351.3.3 m.66109 sp CCD81_HUMAN 43.089 369 198 9 464 826 290 652 1.67E-75 261 CCD81_HUMAN reviewed Coiled-coil domain-containing protein 81 CCDC81 Homo sapiens (Human) 652 0 GO:0005737; GO:0005813 0 0 0 PF14908; Q6ZQQ6 CHOYP_BRAFLDRAFT_127384.2.3 m.46375 sp WDR87_HUMAN 23.466 652 440 18 83 714 48 660 1.67E-45 185 WDR87_HUMAN reviewed WD repeat-containing protein 87 (Testis development protein NYD-SP11) WDR87 Homo sapiens (Human) 2873 0 GO:0005737 0 0 0 PF00400; Q6ZWJ8 CHOYP_KCP.3.13 m.17018 sp KCP_HUMAN 25 328 170 14 29 288 193 512 1.67E-10 65.5 KCP_HUMAN reviewed Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) KCP CRIM2 KCP1 Homo sapiens (Human) 1503 positive regulation of BMP signaling pathway [GO:0030513] GO:0005615; GO:0030513 0 0 0 PF00093;PF00094; Q8ISN9 CHOYP_RS25.5.11 m.17897 sp RS25_BRABE 77.011 87 20 0 54 140 28 114 1.67E-35 122 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8IT98 CHOYP_LOC100378714.2.4 m.30802 sp RS18_ARGIR 87.395 119 15 0 1 119 1 119 1.67E-76 228 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8N9H8 CHOYP_LOC100370838.1.1 m.18679 sp MUT7_HUMAN 27.126 870 545 16 166 991 33 857 1.67E-100 338 MUT7_HUMAN reviewed Exonuclease mut-7 homolog (EC 3.1.-.-) (Exonuclease 3'-5' domain-containing protein 3) EXD3 HBE269 Homo sapiens (Human) 876 0 GO:0003676; GO:0008408; GO:0046872 0 0 0 PF01612;PF01927; Q8VHE6 CHOYP_BRAFLDRAFT_121671.1.1 m.58163 sp DYH5_MOUSE 42.331 163 75 2 28 190 16 159 1.67E-29 117 DYH5_MOUSE reviewed "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (mDNAH5) (Ciliary dynein heavy chain 5)" Dnah5 Dnahc5 Mus musculus (Mouse) 4621 cilium assembly [GO:0042384]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]; sperm motility [GO:0030317] GO:0003341; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0005930; GO:0007368; GO:0007507; GO:0016887; GO:0021670; GO:0030317; GO:0036157; GO:0036158; GO:0042384 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8WZ60 CHOYP_KLHL24.2.4 m.18433 sp KLHL6_HUMAN 26.641 518 354 10 23 519 54 566 1.67E-52 192 KLHL6_HUMAN reviewed Kelch-like protein 6 KLHL6 Homo sapiens (Human) 621 B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467] GO:0002467; GO:0050853 0 0 0 PF07707;PF00651;PF01344; Q92784 CHOYP_ISCW_ISCW007807.1.1 m.50423 sp DPF3_HUMAN 42.857 364 143 7 90 399 13 365 1.67E-84 265 DPF3_HUMAN reviewed Zinc finger protein DPF3 (BRG1-associated factor 45C) (BAF45C) (Zinc finger protein cer-d4) DPF3 BAF45C CERD4 Homo sapiens (Human) 378 "covalent chromatin modification [GO:0016569]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nervous system development [GO:0007399]; positive regulation of defense response to virus by host [GO:0002230]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; xenophagy [GO:0098792]" GO:0002230; GO:0006351; GO:0006355; GO:0007399; GO:0008270; GO:0016569; GO:0071565; GO:0098779; GO:0098792 0 0 0 PF00628;PF14051; Q96MM6 CHOYP_BRAFLDRAFT_57788.4.10 m.32490 sp HS12B_HUMAN 30.805 646 354 19 212 780 43 672 1.67E-87 294 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BXJ4 CHOYP_BRAFLDRAFT_69134.7.13 m.23019 sp C1QT3_HUMAN 32.558 129 79 5 57 181 118 242 1.67E-10 61.2 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9CPU4 CHOYP_NEMVEDRAFT_V1G240887.2.2 m.37649 sp MGST3_MOUSE 46.763 139 67 2 24 155 3 141 1.67E-35 123 MGST3_MOUSE reviewed Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) (Microsomal GST-III) Mgst3 Mus musculus (Mouse) 153 response to organonitrogen compound [GO:0010243] GO:0004364; GO:0004602; GO:0005635; GO:0005783; GO:0005789; GO:0010243; GO:0016020; GO:0016021; GO:0031090; GO:0070062 0 0 0 PF01124; Q9CR89 CHOYP_ERGI2.2.2 m.40828 sp ERGI2_MOUSE 51.247 361 168 5 1 361 1 353 1.67E-130 383 ERGI2_MOUSE reviewed Endoplasmic reticulum-Golgi intermediate compartment protein 2 Ergic2 Mus musculus (Mouse) 377 "ER to Golgi vesicle-mediated transport [GO:0006888]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0005634; GO:0005730; GO:0005737; GO:0005789; GO:0005793; GO:0005794; GO:0006888; GO:0006890; GO:0016020; GO:0016021; GO:0033116; GO:0043231 0 0 0 PF07970; Q9EQ06 CHOYP_LOC100377066.2.2 m.19186 sp DHB11_MOUSE 42.797 236 129 1 10 239 43 278 1.67E-62 206 DHB11_MOUSE reviewed Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8) Hsd17b11 Dhrs8 Pan1b Mus musculus (Mouse) 298 androgen catabolic process [GO:0006710]; steroid biosynthetic process [GO:0006694] GO:0004303; GO:0005576; GO:0005737; GO:0005811; GO:0006694; GO:0006710; GO:0016229; GO:0043231 0 0 0 PF00106; Q9ER30 CHOYP_KLHL2.2.3 m.45405 sp KLH41_RAT 29.907 107 64 2 2 108 182 277 1.67E-07 51.2 KLH41_RAT reviewed Kelch-like protein 41 (Kel-like protein 23) (Kelch repeat and BTB domain-containing protein 10) (Kelch-related protein 1) (Sarcosin) Klhl41 Kbtbd10 Krp1 Rattus norvegicus (Rat) 606 myofibril assembly [GO:0030239]; protein ubiquitination [GO:0016567]; regulation of lateral pseudopodium assembly [GO:0031275]; regulation of myoblast differentiation [GO:0045661]; regulation of myoblast proliferation [GO:2000291]; regulation of skeletal muscle cell differentiation [GO:2001014]; sarcomere organization [GO:0045214]; skeletal muscle cell differentiation [GO:0035914]; skeletal muscle fiber development [GO:0048741] GO:0001726; GO:0005634; GO:0005737; GO:0005789; GO:0005856; GO:0005886; GO:0016567; GO:0030239; GO:0031143; GO:0031275; GO:0031430; GO:0031463; GO:0033017; GO:0035914; GO:0045214; GO:0045661; GO:0048741; GO:2000291; GO:2001014 0 0 0 PF07707;PF00651;PF01344; Q9P0P8 CHOYP_LOC101034657.1.1 m.59333 sp CF203_HUMAN 37.363 91 55 1 155 243 139 229 1.67E-07 54.3 CF203_HUMAN reviewed Uncharacterized protein C6orf203 C6orf203 HSPC230 Homo sapiens (Human) 240 0 GO:0005739 0 0 0 0 Q9UBF6 CHOYP_ISCW_ISCW016510.1.5 m.4083 sp RBX2_HUMAN 90.805 87 8 0 40 126 27 113 1.67E-54 169 RBX2_HUMAN reviewed RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) RNF7 RBX2 ROC2 SAG Homo sapiens (Human) 113 protein neddylation [GO:0045116]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to redox state [GO:0051775]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005507; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0019788; GO:0031146; GO:0031462; GO:0031463; GO:0031466; GO:0031467; GO:0042787; GO:0043224; GO:0045116; GO:0051775; GO:0061630; GO:0080008; GO:0097602 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12678; Q9UKG1 CHOYP_ISCW_ISCW020843.1.1 m.12086 sp DP13A_HUMAN 37.594 266 153 6 61 322 445 701 1.67E-48 176 DP13A_HUMAN reviewed "DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)" APPL1 APPL DIP13A KIAA1428 Homo sapiens (Human) 709 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; insulin receptor signaling pathway [GO:0008286]; regulation of establishment of protein localization to plasma membrane [GO:0090003]; regulation of glucose import [GO:0046324]; signal transduction [GO:0007165] GO:0005634; GO:0005737; GO:0005829; GO:0007049; GO:0007165; GO:0008283; GO:0008286; GO:0010008; GO:0012506; GO:0031901; GO:0042802; GO:0043422; GO:0046324; GO:0070062; GO:0090003; GO:0097192 0 0 0 PF00169;PF00640; Q9Y366 CHOYP_LOC100367604.1.1 m.52335 sp IFT52_HUMAN 68.504 254 79 1 1 253 177 430 1.67E-123 361 IFT52_HUMAN reviewed Intraflagellar transport protein 52 homolog (Protein NGD5 homolog) IFT52 C20orf9 NGD5 CGI-53 Homo sapiens (Human) 437 cilium morphogenesis [GO:0060271]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; negative regulation of epithelial cell proliferation [GO:0050680]; neural tube formation [GO:0001841]; regulation of protein processing [GO:0070613]; smoothened signaling pathway [GO:0007224] GO:0001841; GO:0001947; GO:0005814; GO:0007224; GO:0008022; GO:0009953; GO:0030992; GO:0031514; GO:0032391; GO:0042733; GO:0044292; GO:0050680; GO:0060271; GO:0070613; GO:0072372; GO:0097542; GO:0097546 0 0 0 PF09822; A4IF63 CHOYP_BRAFLDRAFT_86891.2.4 m.38161 sp TRIM2_BOVIN 22.12 217 145 7 4 208 490 694 1.68E-07 54.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5PLG0 CHOYP_LYRM7.1.1 m.35750 sp LYRM7_DANRE 36.842 95 59 1 15 109 3 96 1.68E-16 72.8 LYRM7_DANRE reviewed Complex III assembly factor LYRM7 (LYR motif-containing protein 7) LYRM7 MZM1L zgc:165597 Danio rerio (Zebrafish) (Brachydanio rerio) 104 0 GO:0005759 0 0 0 PF05347; B2RX88 CHOYP_CSPP1.8.14 m.42536 sp CSPP1_MOUSE 33.946 707 334 25 715 1323 498 1169 1.68E-51 202 CSPP1_MOUSE reviewed Centrosome and spindle pole associated protein 1 Cspp1 Cspp Mus musculus (Mouse) 1205 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 B4F785 CHOYP_BRAFLDRAFT_70146.1.1 m.64594 sp EGFLA_RAT 37.188 320 169 3 6 321 364 655 1.68E-65 225 EGFLA_RAT reviewed "Pikachurin (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)" Egflam Rattus norvegicus (Rat) 1005 0 GO:0005509; GO:0005578; GO:0030054; GO:0045202 0 0 0 PF00008;PF00041;PF00054;PF02210; B8I6E7 CHOYP_UUR10_0415.1.1 m.64919 sp IF2_CLOCE 36.598 194 75 12 133 318 300 453 1.68E-12 71.6 IF2_CLOCE reviewed Translation initiation factor IF-2 infB Ccel_0457 Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) 1161 0 GO:0003743; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF11987;PF04760; D2GXS7 CHOYP_TRIM3.18.58 m.30388 sp TRIM2_AILME 25.62 121 79 2 174 292 631 742 1.68E-07 55.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O35796 CHOYP_ISCW_ISCW020550.2.2 m.18099 sp C1QBP_RAT 34.135 208 120 6 94 287 72 276 1.68E-26 108 C1QBP_RAT reviewed "Complement component 1 Q subcomponent-binding protein, mitochondrial (GC1q-R protein) (Glycoprotein gC1qBP) (C1qBP)" C1qbp Gc1qbp Rattus norvegicus (Rat) 279 "apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; mature ribosome assembly [GO:0042256]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001849; GO:0003714; GO:0003729; GO:0005080; GO:0005540; GO:0005615; GO:0005634; GO:0005730; GO:0005737; GO:0005759; GO:0005829; GO:0005886; GO:0006351; GO:0006397; GO:0006915; GO:0006955; GO:0006958; GO:0008380; GO:0009986; GO:0014065; GO:0030449; GO:0030984; GO:0031690; GO:0032689; GO:0032695; GO:0039534; GO:0039536; GO:0042256; GO:0043065; GO:0045087; GO:0045785; GO:0048025; GO:0050687; GO:0051897; GO:0070131; GO:0090023; GO:0097177; GO:1900026; GO:1901165; GO:2000510 0 0 0 PF02330; O75691 CHOYP_UTP20.1.4 m.1267 sp UTP20_HUMAN 40 540 261 9 54 586 584 1067 1.68E-108 361 UTP20_HUMAN reviewed Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) 2785 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of cell proliferation [GO:0008285]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0008285; GO:0030686; GO:0030688; GO:0032040; GO:0044822 0 0 0 PF07539; O93610 CHOYP_BRAFLDRAFT_68004.1.1 m.24323 sp DPOD2_XENLA 53.947 456 206 3 19 472 1 454 1.68E-167 483 DPOD2_XENLA reviewed DNA polymerase delta subunit 2 (EC 2.7.7.7) (XlCdc1) pold2 cdc1 Xenopus laevis (African clawed frog) 463 DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0005634; GO:0006260 0 0 0 PF04042; P02637 CHOYP_SCP.1.12 m.24908 sp SCP_MIZYE 40.341 176 96 6 2 175 2 170 1.68E-32 117 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P04792 CHOYP_LOC100377173.1.2 m.37699 sp HSPB1_HUMAN 38.667 75 43 2 161 233 95 168 1.68E-09 59.3 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P10155 CHOYP_LOC100634688.3.6 m.36725 sp RO60_HUMAN 43.502 554 293 8 42 592 2 538 1.68E-150 449 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P24367 CHOYP_NEMVEDRAFT_V1G191841.1.1 m.1745 sp PPIB_CHICK 68.824 170 53 0 24 193 33 202 1.68E-84 251 PPIB_CHICK reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207 chaperone-mediated protein folding [GO:0061077]; protein peptidyl-prolyl isomerization [GO:0000413] GO:0000413; GO:0003755; GO:0005788; GO:0032403; GO:0032991; GO:0042277; GO:0042470; GO:0061077 0 0 0 PF00160; P33316 CHOYP_LOC100183847.1.2 m.12797 sp DUT_HUMAN 71.242 153 44 0 54 206 100 252 1.68E-76 233 DUT_HUMAN reviewed "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)" DUT Homo sapiens (Human) 252 DNA replication [GO:0006260]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside biosynthetic process [GO:0046134] GO:0000287; GO:0004170; GO:0005634; GO:0005654; GO:0005739; GO:0006139; GO:0006226; GO:0006260; GO:0044822; GO:0046081; GO:0046134; GO:0070062 PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. 0 cd07557; PF00692; P86789 CHOYP_LOC100373107.1.1 m.504 sp GIGA6_CRAGI 24.324 222 158 5 56 273 26 241 1.68E-12 72 GIGA6_CRAGI reviewed Gigasin-6 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 302 0 GO:0016021 0 0 0 PF00144; Q01133 CHOYP_contig_049248 m.58418 sp FMRA_CALPA 24.038 104 78 1 178 281 124 226 1.68E-07 55.5 FMRA_CALPA reviewed Antho-RFamide neuropeptides [Cleaved into: Antho-RFamide] 0 Calliactis parasitica (Sea anemone) (Actinia parasitica) 334 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF01581; Q02543 CHOYP_RL18A.2.8 m.12969 sp RL18A_HUMAN 67.769 121 39 0 1 121 1 121 1.68E-58 182 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q08D69 CHOYP_MED16.1.1 m.15863 sp MED16_XENTR 32.981 852 512 23 1 824 1 821 1.68E-145 452 MED16_XENTR reviewed Mediator of RNA polymerase II transcription subunit 16 (Mediator complex subunit 16) med16 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 828 "positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0006351; GO:0016592; GO:0045893 0 0 0 PF11635; Q09415 CHOYP_MYCGRDRAFT_89575.10.12 m.58160 sp SET14_CAEEL 44.262 61 28 2 205 265 32 86 1.68E-06 54.3 SET14_CAEEL reviewed SET domain-containing protein 14 set-14 R06F6.4 Caenorhabditis elegans 429 0 GO:0003677; GO:0005634; GO:0046872 0 0 0 PF01753; Q0E908 CHOYP_CPIPJ_CPIJ000133.1.2 m.4647 sp HIL_DROME 29.237 472 288 13 465 917 335 779 1.68E-51 199 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q1ZXD6 CHOYP_BRAFLDRAFT_129004.14.15 m.57379 sp ROCO5_DICDI 26.1 341 196 14 490 822 1337 1629 1.68E-14 82.8 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q26630 CHOYP_IDLC.1.1 m.63624 sp IDLC_STRPU 83 100 17 0 1 100 160 259 1.68E-52 167 IDLC_STRPU reviewed "33 kDa inner dynein arm light chain, axonemal (p33)" 0 Strongylocentrotus purpuratus (Purple sea urchin) 260 0 GO:0003774; GO:0030286 0 0 0 PF10211; Q2TGI8 CHOYP_LOC764485.1.2 m.7226 sp ZDH22_RAT 31.492 181 116 3 145 320 73 250 1.68E-20 92.8 ZDH22_RAT reviewed Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) Zdhhc22 Rattus norvegicus (Rat) 263 protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345] GO:0005783; GO:0005794; GO:0008270; GO:0016021; GO:0018345; GO:0019706; GO:0072659 0 0 0 PF01529; Q3SYZ8 CHOYP_ISCW_ISCW000210.3.4 m.15491 sp PDLI3_BOVIN 50 72 35 1 12 82 11 82 1.68E-12 71.2 PDLI3_BOVIN reviewed PDZ and LIM domain protein 3 PDLIM3 Bos taurus (Bovine) 316 actin filament organization [GO:0007015]; heart development [GO:0007507] GO:0007015; GO:0007507; GO:0008270; GO:0008307; GO:0015629; GO:0030018 0 0 0 PF15936;PF00412;PF00595; Q3ZBX6 CHOYP_DWIL_GK10341.1.1 m.21304 sp RM03_BOVIN 41.985 262 135 5 108 369 90 334 1.68E-53 183 RM03_BOVIN reviewed "39S ribosomal protein L3, mitochondrial (L3mt) (MRP-L3)" MRPL3 Bos taurus (Bovine) 348 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005762; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF00297; Q49AA0 CHOYP_ZBT24.1.2 m.36048 sp ZFP69_HUMAN 43.318 217 121 1 218 434 299 513 1.68E-55 202 ZFP69_HUMAN reviewed Zinc finger protein ZFP69 (Zinc finger protein 642) ZFP69 ZNF642 Homo sapiens (Human) 526 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q4LDE5 CHOYP_PHUM_PHUM268120.1.1 m.23332 sp SVEP1_HUMAN 22.848 604 367 24 287 817 478 1055 1.68E-13 79 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5BIP8 CHOYP_LOC100377265.2.2 m.54395 sp DNJB5_BOVIN 55.172 58 25 1 656 713 15 71 1.68E-10 67.4 DNJB5_BOVIN reviewed DnaJ homolog subfamily B member 5 DNAJB5 Bos taurus (Bovine) 348 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986] GO:0000122; GO:0005634; GO:0005829; GO:0006457; GO:0006986 0 0 cd06257; PF00226;PF01556; Q5RA75 CHOYP_PHUM_PHUM293090.1.2 m.10612 sp F135A_PONAB 66.879 314 100 4 713 1025 785 1095 1.68E-135 439 F135A_PONAB reviewed Protein FAM135A FAM135A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1095 0 0 0 0 0 PF12394;PF05057; Q5TC84 CHOYP_OGFRL1.1.1 m.44422 sp OGRL1_HUMAN 42.088 297 161 4 69 358 92 384 1.68E-68 228 OGRL1_HUMAN reviewed Opioid growth factor receptor-like protein 1 OGFRL1 Homo sapiens (Human) 451 0 GO:0004872; GO:0016020 0 0 0 PF04664; Q5UR67 CHOYP_LOC100638431.10.10 m.59513 sp RIBX_MIMIV 46.4 125 67 0 112 236 42 166 1.68E-26 104 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5UR67 CHOYP_LOC100638431.3.10 m.24462 sp RIBX_MIMIV 42.424 165 84 3 107 260 2 166 1.68E-28 110 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5XPI4 CHOYP_RN123.2.2 m.42494 sp RN123_HUMAN 45.302 596 311 6 344 937 732 1314 1.68E-175 548 RN123_HUMAN reviewed E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) RNF123 KPC1 FP1477 Homo sapiens (Human) 1314 protein ubiquitination [GO:0016567] GO:0005737; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622; Q61824 CHOYP_DWIL_GK14446.1.1 m.23748 sp ADA12_MOUSE 33.067 877 518 24 59 911 65 896 1.68E-130 427 ADA12_MOUSE reviewed Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) Adam12 Mltna Mus musculus (Mouse) 903 cell adhesion [GO:0007155]; epidermal growth factor receptor signaling pathway [GO:0007173] GO:0004222; GO:0005654; GO:0005739; GO:0005886; GO:0007155; GO:0007173; GO:0008270; GO:0016021; GO:0017124 0 0 0 PF08516;PF00200;PF01562;PF01421; Q6DDG2 CHOYP_DANA_GF14592.1.1 m.36361 sp K2013_XENLA 31.811 613 378 16 27 621 2 592 1.68E-88 290 K2013_XENLA reviewed Uncharacterized protein KIAA2013 homolog 0 Xenopus laevis (African clawed frog) 604 0 GO:0016021 0 0 0 PF10222; Q6DIB5 CHOYP_MEG11.24.25 m.63448 sp MEG10_MOUSE 38.346 133 73 7 183 314 532 656 1.68E-11 69.7 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6DIB5 CHOYP_TRIADDRAFT_57125.1.1 m.60979 sp MEG10_MOUSE 39.773 88 45 4 38 122 126 208 1.68E-07 55.8 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6ZNE5 CHOYP_BAKOR.1.2 m.33145 sp BAKOR_HUMAN 38.701 354 202 7 13 354 21 371 1.68E-65 220 BAKOR_HUMAN reviewed Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) ATG14 ATG14L KIAA0831 Homo sapiens (Human) 492 autophagosome assembly [GO:0000045]; cellular response to glucose starvation [GO:0042149]; cellular response to starvation [GO:0009267]; endosome to lysosome transport [GO:0008333]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of autophagy [GO:0010508]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein phosphorylation [GO:0001934]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of protein complex stability [GO:0061635]; regulation of protein phosphorylation [GO:0001932]; regulation of triglyceride metabolic process [GO:0090207] GO:0000045; GO:0000421; GO:0001932; GO:0001933; GO:0001934; GO:0005634; GO:0005737; GO:0005776; GO:0005789; GO:0005829; GO:0005930; GO:0008333; GO:0009267; GO:0010508; GO:0010608; GO:0016236; GO:0034045; GO:0035032; GO:0042149; GO:0043552; GO:0044233; GO:0045335; GO:0061635; GO:0090207; GO:0097629; GO:0097632; GO:0098779 0 0 0 PF10186; Q86X40 CHOYP_contig_054721 m.65299 sp LRC28_HUMAN 25.984 254 129 7 32 277 158 360 1.68E-11 67.4 LRC28_HUMAN reviewed Leucine-rich repeat-containing protein 28 LRRC28 UNQ436/PRO867 Homo sapiens (Human) 367 0 0 0 0 0 PF13855; Q8BVV7 CHOYP_LOC100372020.1.1 m.59998 sp CEP95_MOUSE 45.635 252 137 0 630 881 563 814 1.68E-67 244 CEP95_MOUSE reviewed Centrosomal protein of 95 kDa (Cep95) (Coiled-coil domain-containing protein 45) Cep95 Ccdc45 Mus musculus (Mouse) 827 0 GO:0000922; GO:0005737; GO:0005813 0 0 0 0 Q8K310 CHOYP_RBM20.1.2 m.2222 sp MATR3_MOUSE 58.333 48 20 0 840 887 783 830 1.68E-12 75.5 MATR3_MOUSE reviewed Matrin-3 Matr3 Mus musculus (Mouse) 846 heart valve development [GO:0003170]; posttranscriptional regulation of gene expression [GO:0010608]; ventricular septum development [GO:0003281] GO:0000166; GO:0003170; GO:0003281; GO:0005634; GO:0005654; GO:0008270; GO:0010608; GO:0016020; GO:0016363; GO:0044822 0 0 0 0 Q8NEZ4 CHOYP_MLL3.2.3 m.25295 sp KMT2C_HUMAN 35.33 818 436 24 19 778 924 1706 1.68E-131 469 KMT2C_HUMAN reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) 4911 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0008270; GO:0016746; GO:0018024; GO:0035097; GO:0042800; GO:0044666; GO:0044822 0 0 0 PF05965;PF05964;PF00628;PF00856; Q8TC92 CHOYP_LOC660510.1.1 m.56257 sp ENOX1_HUMAN 53.763 279 117 2 83 353 76 350 1.68E-102 320 ENOX1_HUMAN reviewed Ecto-NOX disulfide-thiol exchanger 1 (Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase) (cCNOX) (Cell proliferation-inducing gene 38 protein) (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] ENOX1 PIG38 Homo sapiens (Human) 643 rhythmic process [GO:0048511] GO:0000166; GO:0003676; GO:0005615; GO:0005886; GO:0016491; GO:0048511 0 0 0 PF00076; Q92485 CHOYP_LOC100378213.1.1 m.31485 sp ASM3B_HUMAN 36.952 433 251 10 42 463 16 437 1.68E-94 296 ASM3B_HUMAN reviewed Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B Homo sapiens (Human) 455 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; membrane lipid catabolic process [GO:0046466]; negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685] GO:0004767; GO:0005615; GO:0005886; GO:0006685; GO:0006954; GO:0008081; GO:0016798; GO:0031225; GO:0034122; GO:0045087; GO:0046466; GO:0046872; GO:0050728; GO:0070062 0 0 0 PF00149; Q96M20 CHOYP_LOC584085.1.1 m.13678 sp CNBD2_HUMAN 23.678 435 287 12 102 523 99 501 1.68E-18 92.4 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96XY5 CHOYP_LOC100640803.1.1 m.48027 sp Y2383_SULTO 40.476 84 43 2 15 98 60 136 1.68E-09 60.8 Y2383_SULTO reviewed Uncharacterized protein STK_23830 STK_23830 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 182 0 0 0 0 0 PF01661; Q99M80 CHOYP_PTPRA.6.22 m.33617 sp PTPRT_MOUSE 42.969 256 143 2 407 660 902 1156 1.68E-55 208 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99N85 CHOYP_MRPS18A.1.1 m.44278 sp RT18A_MOUSE 46.067 89 43 2 7 93 49 134 1.68E-18 79.7 RT18A_MOUSE reviewed "28S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (28S ribosomal protein S18-3, mitochondrial) (MRP-S18-3)" Mrps18a Mus musculus (Mouse) 196 mitochondrial translation [GO:0032543] GO:0003735; GO:0005739; GO:0005763; GO:0022627; GO:0032543 0 0 0 PF01084; Q9BMN8 CHOYP_LAR.1.2 m.30133 sp LAR_CAEEL 22.208 770 466 35 92 770 62 789 1.68E-10 68.9 LAR_CAEEL reviewed Tyrosine-protein phosphatase Lar-like (EC 3.1.3.48) (Protein-tyrosine phosphate 3) ptp-3 C09D8.1/C09D8.2 Caenorhabditis elegans 2200 embryonic body morphogenesis [GO:0010172]; epidermis development [GO:0008544]; gastrulation [GO:0007369]; motor neuron axon guidance [GO:0008045]; nervous system development [GO:0007399]; neuroblast migration [GO:0097402]; neuron migration [GO:0001764]; protein dephosphorylation [GO:0006470]; protein localization to synapse [GO:0035418]; synapse assembly [GO:0007416] GO:0001764; GO:0004725; GO:0005001; GO:0005886; GO:0005912; GO:0006470; GO:0007369; GO:0007399; GO:0007416; GO:0008045; GO:0008544; GO:0010172; GO:0016021; GO:0035418; GO:0045202; GO:0097402 0 0 0 PF00041;PF07679;PF00102; Q9DB91 CHOYP_LOC101073830.1.1 m.42117 sp MED29_MOUSE 42.446 139 75 3 38 175 54 188 1.68E-29 110 MED29_MOUSE reviewed Mediator of RNA polymerase II transcription subunit 29 (Intersex-like protein) (Mediator complex subunit 29) Med29 Ixl Mus musculus (Mouse) 199 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005654; GO:0006351; GO:0006355; GO:0016592 0 0 0 PF11568; Q9H5L6 CHOYP_LOC100636811.2.2 m.62707 sp THAP9_HUMAN 30.769 130 76 3 55 172 1 128 1.68E-09 62.4 THAP9_HUMAN reviewed DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9) THAP9 Homo sapiens (Human) 903 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, DNA-mediated [GO:0006313]" GO:0004803; GO:0006310; GO:0006313; GO:0015074; GO:0016740; GO:0043565; GO:0046872 0 0 0 PF05485;PF12017; Q9NZJ4 CHOYP_SACS.7.17 m.37176 sp SACS_HUMAN 30.288 1182 721 35 40 1154 2045 3190 1.68E-127 436 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9QUN7 CHOYP_TLR2.4.7 m.43917 sp TLR2_MOUSE 38.614 101 60 2 14 112 641 741 1.68E-11 64.7 TLR2_MOUSE reviewed Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) 784 cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to peptidoglycan [GO:0071224]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; chloramphenicol transport [GO:0042892]; cytokine secretion involved in immune response [GO:0002374]; defense response to Gram-positive bacterium [GO:0050830]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; induction by symbiont of defense-related host nitric oxide production [GO:0052063]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-10 production [GO:0032613]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-17 production [GO:0032700]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of xenophagy [GO:1904417]; regulation of dendritic cell cytokine production [GO:0002730]; response to bacterium [GO:0009617]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; toll-like receptor 2 signaling pathway [GO:0034134] GO:0001530; GO:0002238; GO:0002374; GO:0002687; GO:0002730; GO:0002752; GO:0002755; GO:0004872; GO:0004888; GO:0005737; GO:0005794; GO:0005886; GO:0006954; GO:0007252; GO:0008329; GO:0009617; GO:0009897; GO:0009986; GO:0010628; GO:0016021; GO:0030177; GO:0030670; GO:0031226; GO:0032494; GO:0032613; GO:0032695; GO:0032700; GO:0032722; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0032757; GO:0032760; GO:0034123; GO:0034134; GO:0035325; GO:0035354; GO:0035355; GO:0042346; GO:0042495; GO:0042496; GO:0042497; GO:0042498; GO:0042535; GO:0042834; GO:0042892; GO:0044130; GO:0045087; GO:0045121; GO:0045429; GO:0045944; GO:0046982; GO:0050715; GO:0050729; GO:0050830; GO:0051092; GO:0051770; GO:0052063; GO:0060907; GO:0070374; GO:0070891; GO:0071221; GO:0071223; GO:0071224; GO:0071726; GO:0071727; GO:1901224; GO:1904417 0 0 0 PF13516;PF13855;PF01582; Q9VXX8 CHOYP_SNOG_00234.1.1 m.28722 sp RL371_DROME 70.37 81 24 0 43 123 1 81 1.68E-35 120 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9Y091 CHOYP_SODM.1.2 m.45530 sp FL2D_DROME 58.511 94 39 0 1 94 221 314 1.68E-27 113 FL2D_DROME reviewed Pre-mRNA-splicing regulator female-lethal(2)D (dFL(2)D) fl(2)d CG6315 Drosophila melanogaster (Fruit fly) 536 "compound eye development [GO:0048749]; female germ-line sex determination [GO:0019099]; lateral inhibition [GO:0046331]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; primary sex determination, soma [GO:0007539]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing, via transesterification reactions [GO:0000375]; sex determination [GO:0007530]" GO:0000375; GO:0000381; GO:0005634; GO:0006397; GO:0007530; GO:0007539; GO:0019099; GO:0046331; GO:0048749; GO:0080009 0 0 0 PF17098; Q9Y5X2 CHOYP_LOC575600.1.1 m.27851 sp SNX8_HUMAN 49.01 404 201 2 116 518 58 457 1.68E-141 419 SNX8_HUMAN reviewed Sorting nexin-8 SNX8 Homo sapiens (Human) 465 early endosome to Golgi transport [GO:0034498]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; vesicle organization [GO:0016050] GO:0005829; GO:0006886; GO:0006897; GO:0016050; GO:0019898; GO:0031901; GO:0034498; GO:0035091; GO:0042802; GO:0043231 0 0 0 PF00787; Q9Y6K5 CHOYP_BRAFLDRAFT_66572.2.3 m.51580 sp OAS3_HUMAN 30.671 313 187 7 84 368 753 1063 1.68E-35 141 OAS3_HUMAN reviewed 2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS) OAS3 P/OKcl.4 Homo sapiens (Human) 1087 defense response to virus [GO:0051607]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of viral genome replication [GO:0045071]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of ribonuclease activity [GO:0060700]; response to virus [GO:0009615]; type I interferon signaling pathway [GO:0060337] GO:0001730; GO:0003725; GO:0005524; GO:0005615; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006139; GO:0009615; GO:0043231; GO:0045071; GO:0046872; GO:0051607; GO:0060333; GO:0060337; GO:0060700 0 0 0 PF01909;PF10421; A2AGA4 CHOYP_BRAFLDRAFT_113602.1.1 m.10823 sp RHBL2_MOUSE 38.911 257 143 5 117 372 52 295 1.69E-52 179 RHBL2_MOUSE reviewed "Rhomboid-related protein 2 (RRP2) (EC 3.4.21.105) [Cleaved into: Rhomboid-related protein 2, N-terminal fragment (NTF); Rhomboid-related protein 2, C-terminal fragment (CTF)]" Rhbdl2 Mus musculus (Mouse) 302 protein processing [GO:0016485] GO:0004252; GO:0005743; GO:0005886; GO:0016021; GO:0016485 0 0 0 PF01694; A4IF63 CHOYP_TRIM2.52.59 m.57816 sp TRIM2_BOVIN 26.923 208 135 8 5 203 545 744 1.69E-11 66.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4QNW7 CHOYP_CRE_03678.1.3 m.21860 sp PHIPL_DANRE 31.41 156 105 2 38 192 187 341 1.69E-17 82.8 PHIPL_DANRE reviewed Phytanoyl-CoA hydroxylase-interacting protein-like phyhipl zgc:100983 Danio rerio (Zebrafish) (Brachydanio rerio) 377 0 0 0 0 0 PF00041; A6YLM6 CHOYP_LOC100907253.2.3 m.2261 sp FABP4_CEREL 31.683 101 64 2 5 105 37 132 1.69E-08 52 FABP4_CEREL reviewed "Fatty acid-binding protein, adipocyte (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)" FABP4 Cervus elaphus (Red deer) 132 regulation of inflammatory response [GO:0050727] GO:0005215; GO:0005504; GO:0005634; GO:0005737; GO:0050727 0 0 0 PF00061; D2GXS7 CHOYP_BRAFLDRAFT_67264.2.6 m.32586 sp TRIM2_AILME 24.889 225 151 8 194 408 492 708 1.69E-06 53.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_69764.6.19 m.23968 sp TRIM2_AILME 25.62 242 134 6 179 374 492 733 1.69E-13 75.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14522 CHOYP_PTPRT.17.45 m.42361 sp PTPRT_HUMAN 28.453 724 422 16 3 665 752 1440 1.69E-77 273 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O15455 CHOYP_LOC100376153.1.1 m.36463 sp TLR3_HUMAN 25.788 888 547 26 7 820 7 856 1.69E-54 207 TLR3_HUMAN reviewed Toll-like receptor 3 (CD antigen CD283) TLR3 Homo sapiens (Human) 904 activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic signaling pathway [GO:0097190]; cellular response to drug [GO:0035690]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to interferon-gamma [GO:0071346]; cellular response to mechanical stimulus [GO:0071260]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; microglial cell activation involved in immune response [GO:0002282]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha biosynthetic process [GO:0045356]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type III interferon production [GO:0034346]; regulation of dendritic cell cytokine production [GO:0002730]; response to exogenous dsRNA [GO:0043330]; signal transduction [GO:0007165]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] GO:0000139; GO:0002224; GO:0002282; GO:0002730; GO:0002756; GO:0003725; GO:0004872; GO:0004888; GO:0005622; GO:0005737; GO:0005765; GO:0005769; GO:0005789; GO:0005887; GO:0006954; GO:0006972; GO:0007165; GO:0007249; GO:0007250; GO:0007252; GO:0008584; GO:0009597; GO:0010008; GO:0010628; GO:0016020; GO:0032722; GO:0032728; GO:0032735; GO:0032755; GO:0032757; GO:0032760; GO:0034123; GO:0034128; GO:0034138; GO:0034346; GO:0035458; GO:0035666; GO:0035690; GO:0036020; GO:0042346; GO:0042742; GO:0042802; GO:0043065; GO:0043330; GO:0045078; GO:0045080; GO:0045087; GO:0045356; GO:0045359; GO:0045671; GO:0045944; GO:0046330; GO:0050729; GO:0051092; GO:0051607; GO:0070266; GO:0071260; GO:0071346; GO:0071360; GO:0097190; GO:0097191; GO:0097527 0 0 0 PF13516;PF13855;PF01582; O43719 CHOYP_LOC100696985.1.1 m.17599 sp HTSF1_HUMAN 44.472 407 151 8 10 404 12 355 1.69E-99 318 HTSF1_HUMAN reviewed HIV Tat-specific factor 1 (Tat-SF1) HTATSF1 Homo sapiens (Human) 755 "mRNA splicing, via spliceosome [GO:0000398]; regulation of DNA-templated transcription, elongation [GO:0032784]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; viral genome replication [GO:0019079]" GO:0000166; GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0005684; GO:0005686; GO:0006351; GO:0006357; GO:0019079; GO:0032784; GO:0044822 0 0 0 PF00076; O70511 CHOYP_TVAG_168010.17.45 m.37283 sp ANK3_RAT 34.384 730 453 5 30 750 48 760 1.69E-119 399 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O75096 CHOYP_LOC100374813.2.2 m.39807 sp LRP4_HUMAN 35.385 260 162 4 2 258 787 1043 1.69E-40 161 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; O88874 CHOYP_LOC100123595.1.2 m.63353 sp CCNK_MOUSE 70.492 244 70 2 20 263 22 263 1.69E-124 381 CCNK_MOUSE reviewed Cyclin-K Ccnk Mus musculus (Mouse) 554 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; in utero embryonic development [GO:0001701]; mitotic nuclear division [GO:0007067]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of cell cycle arrest [GO:0071157]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of phosphorylation of RNA polymerase II C-terminal domain [GO:1901409]; positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [GO:2001165]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000307; GO:0001701; GO:0002944; GO:0002945; GO:0004693; GO:0005634; GO:0005654; GO:0006351; GO:0006974; GO:0007067; GO:0008353; GO:0016538; GO:0019901; GO:0044828; GO:0045737; GO:0045944; GO:0051301; GO:0071157; GO:1901409; GO:2001165 0 0 0 PF02984;PF00134; P10079 CHOYP_LOC100634060.15.37 m.34468 sp FBP1_STRPU 54.268 328 150 0 1 328 194 521 1.69E-108 342 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_LOC100634060.8.37 m.21881 sp FBP1_STRPU 52.555 274 130 0 1 274 246 519 1.69E-84 282 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P15989 CHOYP_LOC101173335.4.4 m.49815 sp CO6A3_CHICK 22.25 2009 1259 65 706 2646 38 1811 1.69E-98 361 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P17420 CHOYP_contig_015335 m.17852 sp FIMDD_DICNO 27.5 360 197 18 30 377 63 370 1.69E-17 86.7 FIMDD_DICNO reviewed "Putative fimbrial assembly protein FimD, serogroup D" fimD Dichelobacter nodosus (Bacteroides nodosus) 394 0 0 0 0 0 PF00144; P34257 CHOYP_LOC101238723.2.2 m.44329 sp TC3A_CAEEL 35.135 111 53 5 1 111 181 272 1.69E-06 49.3 TC3A_CAEEL reviewed Transposable element Tc3 transposase tc3a B0303.5 Caenorhabditis elegans 329 "developmental process [GO:0032502]; DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074; GO:0032502 0 0 0 PF11427;PF01498; P35589 CHOYP_SYB.2.3 m.46506 sp SYB_APLCA 85.859 99 14 0 16 114 19 117 1.69E-45 148 SYB_APLCA reviewed Synaptobrevin 0 Aplysia californica (California sea hare) 180 vesicle-mediated transport [GO:0016192] GO:0016021; GO:0016192; GO:0030054; GO:0030672; GO:0043005 0 0 0 PF00957; P41894 CHOYP_LOC100898511.1.1 m.62824 sp DEI_DROME 45.69 116 58 1 49 159 42 157 1.69E-18 86.3 DEI_DROME reviewed Helix-loop-helix protein delilah (Protein taxi) tx dei CG5441 Drosophila melanogaster (Fruit fly) 384 "cell adhesion mediated by integrin [GO:0033627]; imaginal disc-derived wing vein specification [GO:0007474]; mesoderm development [GO:0007498]; muscle attachment [GO:0016203]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription, DNA-templated [GO:0006355]; somatic muscle development [GO:0007525]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007474; GO:0007498; GO:0007525; GO:0010906; GO:0016203; GO:0033627; GO:0043425; GO:0046982 0 0 0 PF00010; P46209 CHOYP_NEMVEDRAFT_V1G164392.3.3 m.59979 sp USF_AQUPY 33.987 153 88 4 4 148 56 203 1.69E-17 80.5 USF_AQUPY reviewed Protein usf usf Aquifex pyrophilus 231 0 GO:0016787 0 0 0 PF01738; P49013 CHOYP_NOTC2.2.5 m.39164 sp FBP3_STRPU 40.625 256 137 1 494 749 217 457 1.69E-56 210 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P50164 CHOYP_PHUM_PHUM411890.1.1 m.6831 sp TRN2_HYONI 39.796 98 58 1 2 99 162 258 1.69E-16 75.1 TRN2_HYONI reviewed Tropinone reductase 2 (EC 1.1.1.236) (Tropinone reductase II) (TR-II) TR2 Hyoscyamus niger (Black henbane) 260 tropane alkaloid biosynthetic process [GO:0009710] GO:0009710; GO:0050358 PATHWAY: Alkaloid biosynthesis; tropane alkaloid biosynthesis. 0 0 0 P83741 CHOYP_WNK2.2.2 m.63927 sp WNK1_MOUSE 68.966 377 112 3 274 648 192 565 1.69E-165 563 WNK1_MOUSE reviewed Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) Wnk1 Hsn2 Prkwnk1 Mus musculus (Mouse) 2377 intracellular signal transduction [GO:0035556]; ion transport [GO:0006811]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of phosphatase activity [GO:0010923]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of systemic arterial blood pressure [GO:0003084]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cellular process [GO:0050794]; regulation of ion homeostasis [GO:2000021] GO:0000287; GO:0003084; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006811; GO:0010923; GO:0019869; GO:0019870; GO:0019902; GO:0030291; GO:0032414; GO:0035556; GO:0046777; GO:0050794; GO:0090188; GO:2000021 0 0 0 PF12202;PF00069; Q12955 CHOYP_TVAG_168010.22.45 m.51624 sp ANK3_HUMAN 33.242 728 450 2 112 803 61 788 1.69E-128 427 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q12955 CHOYP_TVAG_470020.4.8 m.24801 sp ANK3_HUMAN 38.835 103 45 3 137 239 111 195 1.69E-10 64.3 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q24307 CHOYP_BIR7A.2.2 m.55077 sp DIAP2_DROME 43.243 74 42 0 113 186 425 498 1.69E-16 79.7 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q3TAE8 CHOYP_ALG6.1.1 m.33512 sp ALG6_MOUSE 49.299 499 230 4 8 483 9 507 1.69E-156 457 ALG6_MOUSE reviewed "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase)" Alg6 Mus musculus (Mouse) 507 oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487] GO:0005789; GO:0006487; GO:0006490; GO:0016020; GO:0016021; GO:0042281; GO:0046527 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03155; Q4LDE5 CHOYP_LOC100367084.21.22 m.63387 sp SVEP1_HUMAN 25.184 814 495 25 103 841 332 1106 1.69E-39 165 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5EAE6 CHOYP_ISCW_ISCW005083.1.2 m.37654 sp DAP1_BOVIN 39.815 108 58 2 1 108 1 101 1.69E-17 74.3 DAP1_BOVIN reviewed Death-associated protein 1 (DAP-1) DAP Bos taurus (Bovine) 102 apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507] GO:0006914; GO:0010507; GO:0034198; GO:0070513; GO:0097190 0 0 0 PF15228; Q5EAR5 CHOYP_BRAFLDRAFT_265162.2.3 m.63945 sp TRPT1_DANRE 50.732 205 94 4 245 445 23 224 1.69E-62 213 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q5EHP4 CHOYP_CM32.1.1 m.35138 sp CM32_CONLE 71.622 74 15 2 30 102 1 69 1.69E-28 100 CM32_CONLE reviewed Conotoxin Lp3.2 0 Conus leopardus (Leopard cone) 70 pathogenesis [GO:0009405] GO:0005576; GO:0008200; GO:0009405 0 0 0 PF02950; Q5R941 CHOYP_contig_009685 m.11265 sp FKB14_PONAB 25.604 207 141 6 13 212 8 208 1.69E-06 50.8 FKB14_PONAB reviewed Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase) FKBP14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 211 protein folding [GO:0006457] GO:0003755; GO:0005509; GO:0005788; GO:0006457 0 0 0 PF13499;PF00254; Q5U4U6 CHOYP_WARS.1.1 m.25084 sp T23O_XENLA 36.86 293 168 5 8 284 40 331 1.69E-57 193 T23O_XENLA reviewed "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" tdo2 Xenopus laevis (African clawed frog) 406 tryptophan catabolic process to kynurenine [GO:0019441] GO:0004833; GO:0019441; GO:0020037; GO:0046872 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}. 0 0 PF03301; Q60989 CHOYP_XIAP.7.7 m.66325 sp XIAP_MOUSE 34.021 97 55 2 242 332 246 339 1.69E-07 56.2 XIAP_MOUSE reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) 496 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; neuron apoptotic process [GO:0051402]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005737; GO:0008270; GO:0016055; GO:0016874; GO:0031398; GO:0043027; GO:0043066; GO:0043154; GO:0051402; GO:0061630; GO:0090263; GO:1902530; GO:1990001 0 0 0 PF00653; Q6DFJ6 CHOYP_TBK1.5.5 m.67030 sp TBK1_XENLA 48.305 118 61 0 16 133 2 119 1.69E-31 121 TBK1_XENLA reviewed Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) tbk1 Xenopus laevis (African clawed frog) 725 innate immune response [GO:0045087] GO:0004674; GO:0005524; GO:0005737; GO:0045087 0 0 0 PF00069; Q6DJ83 CHOYP_CADM2.1.2 m.24515 sp CADM2_XENTR 27.236 246 147 7 159 404 89 302 1.69E-11 70.9 CADM2_XENTR reviewed Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) cadm2 igsf4d Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 433 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0042803; GO:0050839 0 0 0 PF08205;PF07686; Q6INR1 CHOYP_ISCW_ISCW021601.1.2 m.12154 sp EIF3J_XENLA 45.669 127 51 6 5 115 8 132 1.69E-14 70.1 EIF3J_XENLA reviewed Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35) eif3j eif3s1 Xenopus laevis (African clawed frog) 255 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446] GO:0001731; GO:0003743; GO:0005852; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF08597; Q6PCF9 CHOYP_BRAFLDRAFT_90902.2.2 m.52262 sp S38AA_XENLA 33.287 718 371 17 3 622 2 709 1.69E-109 363 S38AA_XENLA reviewed Putative sodium-coupled neutral amino acid transporter 10 (Solute carrier family 38 member 10) slc38a10 Xenopus laevis (African clawed frog) 1045 amino acid transport [GO:0006865]; sodium ion transport [GO:0006814] GO:0006814; GO:0006865; GO:0016021 0 0 cd06174; PF01490; Q6UW02 CHOYP_ISCW_ISCW001592.2.2 m.39325 sp CP20A_HUMAN 36.211 475 283 7 28 496 1 461 1.69E-98 307 CP20A_HUMAN reviewed Cytochrome P450 20A1 (EC 1.14.-.-) CYP20A1 UNQ667/PRO1301 Homo sapiens (Human) 462 0 GO:0004497; GO:0005506; GO:0016020; GO:0016021; GO:0016705; GO:0020037 0 0 0 PF00067; Q6V0I7 CHOYP_RB886.1.1 m.36185 sp FAT4_HUMAN 22.291 1135 743 45 181 1225 419 1504 1.69E-24 115 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q6ZPT1 CHOYP_LOC100377303.1.1 m.45139 sp KLHL9_MOUSE 30.89 573 378 9 57 621 33 595 1.69E-90 295 KLHL9_MOUSE reviewed Kelch-like protein 9 Klhl9 Kiaa1354 Mus musculus (Mouse) 617 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q7TN84 CHOYP_LOC100369472.2.2 m.60008 sp SYT14_MOUSE 41.772 553 272 13 5 524 20 555 1.69E-132 399 SYT14_MOUSE reviewed Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV) Syt14 Mus musculus (Mouse) 555 vesicle fusion [GO:0006906] GO:0005509; GO:0005543; GO:0005886; GO:0006906; GO:0016021; GO:0019905; GO:0030276; GO:0042803; GO:0046982 0 0 0 PF00168; Q8K4G1 CHOYP_LOC100368088.1.1 m.50453 sp LTBP4_MOUSE 38.486 317 161 19 9 309 628 926 1.69E-39 151 LTBP4_MOUSE reviewed Latent-transforming growth factor beta-binding protein 4 (LTBP-4) Ltbp4 Mus musculus (Mouse) 1666 hormone secretion [GO:0046879]; regulation of proteolysis [GO:0030162]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005509; GO:0005578; GO:0005615; GO:0007179; GO:0030162; GO:0031012; GO:0046879; GO:0050431; GO:0070062 0 0 0 PF07645;PF00683; Q8N6F8 CHOYP_BRAFLDRAFT_130131.1.1 m.11020 sp WBS27_HUMAN 35.838 173 107 4 39 211 32 200 1.69E-27 107 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q8NFT2 CHOYP_BRAFLDRAFT_110761.1.1 m.37491 sp STEA2_HUMAN 37.307 453 256 9 7 445 30 468 1.69E-95 300 STEA2_HUMAN reviewed Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1) STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203 Homo sapiens (Human) 490 copper ion import [GO:0015677]; endocytosis [GO:0006897]; ferric iron import into cell [GO:0097461]; Golgi to plasma membrane transport [GO:0006893]; iron ion homeostasis [GO:0055072]; regulated exocytosis [GO:0045055]; response to hormone [GO:0009725] GO:0005215; GO:0005769; GO:0005829; GO:0005886; GO:0005887; GO:0006893; GO:0006897; GO:0008823; GO:0009725; GO:0010008; GO:0015677; GO:0030140; GO:0030173; GO:0043231; GO:0045055; GO:0046872; GO:0052851; GO:0055072; GO:0097461 0 0 0 PF03807;PF01794; Q8NHV1 CHOYP_GIMA7.1.4 m.3632 sp GIMA7_HUMAN 29.323 133 74 4 2 129 105 222 1.69E-10 63.2 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8TC29 CHOYP_LOC578858.1.2 m.7426 sp ENKUR_HUMAN 51.415 212 97 2 1 212 49 254 1.69E-72 223 ENKUR_HUMAN reviewed Enkurin ENKUR C10orf63 Homo sapiens (Human) 256 0 GO:0001669; GO:0097228 0 0 0 PF13864; Q8TEQ8 CHOYP_LOC100378806.1.1 m.16402 sp PIGO_HUMAN 32.649 1121 646 33 5 1063 10 1083 1.69E-159 503 PIGO_HUMAN reviewed GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O) PIGO UNQ632/PRO1249 Homo sapiens (Human) 1089 GPI anchor biosynthetic process [GO:0006506] GO:0005789; GO:0006506; GO:0016020; GO:0016021; GO:0051377 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF01663; Q8VHI3 CHOYP_OFUT2.1.1 m.29777 sp OFUT2_MOUSE 47.796 431 208 9 15 435 6 429 1.69E-126 375 OFUT2_MOUSE reviewed GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) Pofut2 Mus musculus (Mouse) 429 fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]; mesoderm formation [GO:0001707]; protein O-linked fucosylation [GO:0036066]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046] GO:0001707; GO:0005783; GO:0005794; GO:0006004; GO:0008417; GO:0010468; GO:0010717; GO:0036065; GO:0036066; GO:0046922; GO:0051046 PATHWAY: Protein modification; protein glycosylation. 0 0 PF10250; Q8WV41 CHOYP_BRAFLDRAFT_126596.1.1 m.64385 sp SNX33_HUMAN 35.41 610 336 7 26 614 1 573 1.69E-134 408 SNX33_HUMAN reviewed Sorting nexin-33 (SH3 and PX domain-containing protein 3) SNX33 SH3PX3 SH3PXD3C SNX30 Homo sapiens (Human) 574 cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; macropinocytosis [GO:0044351]; membrane tubulation [GO:0097320]; mitotic cytokinesis [GO:0000281]; mitotic nuclear division [GO:0007067]; negative regulation of endocytosis [GO:0045806]; negative regulation of protein localization to cell surface [GO:2000009]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein localization to cell surface [GO:2000010]; protein import [GO:0017038]; vesicle organization [GO:0016050] GO:0000281; GO:0005768; GO:0005829; GO:0006886; GO:0006897; GO:0007032; GO:0007067; GO:0016020; GO:0016023; GO:0016050; GO:0016197; GO:0017038; GO:0019898; GO:0030659; GO:0035091; GO:0036089; GO:0042802; GO:0044351; GO:0045806; GO:0051044; GO:0097320; GO:2000009; GO:2000010 0 0 0 PF10456;PF00787;PF14604; Q93075 CHOYP_LOC100373138.1.1 m.23492 sp TATD2_HUMAN 27.53 247 143 8 12 244 490 714 1.69E-18 89.4 TATD2_HUMAN reviewed Putative deoxyribonuclease TATDN2 (EC 3.1.21.-) TATDN2 KIAA0218 Homo sapiens (Human) 761 DNA catabolic process [GO:0006308]; IRE1-mediated unfolded protein response [GO:0036498] GO:0004536; GO:0005634; GO:0005654; GO:0005737; GO:0006308; GO:0016888; GO:0036498; GO:0046872 0 0 0 PF01026; Q96GP6 CHOYP_LOC101068272.2.3 m.42851 sp SREC2_HUMAN 39.375 160 92 4 1 160 265 419 1.69E-23 99 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9BGT1 CHOYP_LOC100366957.1.1 m.10938 sp TTC9C_MACFA 36.416 173 102 4 11 178 2 171 1.69E-31 115 TTC9C_MACFA reviewed Tetratricopeptide repeat protein 9C (TPR repeat protein 9C) TTC9C QflA-13179 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 171 0 0 0 0 0 PF07719; Q9BVV8 CHOYP_BRAFLDRAFT_122141.1.1 m.51229 sp CS024_HUMAN 30.909 110 59 3 37 146 35 127 1.69E-08 53.1 CS024_HUMAN reviewed Uncharacterized membrane protein C19orf24 C19orf24 Homo sapiens (Human) 132 0 GO:0005576; GO:0005737; GO:0016021 0 0 0 PF06679; Q9D7V9 CHOYP_NAAA.1.1 m.13116 sp NAAA_MOUSE 44.063 320 175 2 31 350 37 352 1.69E-95 291 NAAA_MOUSE reviewed N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] Naaa Asahl Mus musculus (Mouse) 362 lipid metabolic process [GO:0006629] GO:0005737; GO:0005764; GO:0006629; GO:0008134; GO:0016810; GO:0070062 0 0 0 PF02275;PF15508; Q9DA39 CHOYP_BRAFLDRAFT_115358.1.2 m.7016 sp LFG4_MOUSE 43.056 216 123 0 10 225 15 230 1.69E-48 162 LFG4_MOUSE reviewed Protein lifeguard 4 (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) Tmbim4 Lfg4 Mus musculus (Mouse) 238 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; regulation of calcium-mediated signaling [GO:0050848] GO:0000139; GO:0005795; GO:0006915; GO:0016021; GO:0043066; GO:0050848 0 0 0 0 Q9DA39 CHOYP_NAA15.1.1 m.34960 sp LFG4_MOUSE 43.056 216 123 0 10 225 15 230 1.69E-48 162 LFG4_MOUSE reviewed Protein lifeguard 4 (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) Tmbim4 Lfg4 Mus musculus (Mouse) 238 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; regulation of calcium-mediated signaling [GO:0050848] GO:0000139; GO:0005795; GO:0006915; GO:0016021; GO:0043066; GO:0050848 0 0 0 0 Q9ESN6 CHOYP_LOC100370725.2.5 m.27915 sp TRIM2_MOUSE 28.342 187 107 8 346 521 536 706 1.69E-09 63.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JLC8 CHOYP_NEMVEDRAFT_V1G247395.6.8 m.36005 sp SACS_MOUSE 25.284 617 384 19 7 602 2698 3258 1.69E-42 169 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9NBX4 CHOYP_LOC752194.1.12 m.644 sp RTXE_DROME 30.519 154 101 3 158 308 408 558 1.69E-12 71.6 RTXE_DROME reviewed Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) 908 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q9NZJ4 CHOYP_LOC100378394.1.1 m.37834 sp SACS_HUMAN 24.138 435 243 17 109 472 4153 4571 1.69E-14 80.1 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9UHN1 CHOYP_LOC101072367.1.1 m.54106 sp DPOG2_HUMAN 25.954 262 125 6 2 203 59 311 1.69E-17 83.2 DPOG2_HUMAN reviewed "DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7) (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta)" POLG2 MTPOLB Homo sapiens (Human) 485 DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; glycyl-tRNA aminoacylation [GO:0006426]; in utero embryonic development [GO:0001701]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; respiratory electron transport chain [GO:0022904] GO:0000262; GO:0001701; GO:0003677; GO:0003887; GO:0004820; GO:0005759; GO:0006260; GO:0006261; GO:0006281; GO:0006426; GO:0007005; GO:0022904; GO:0032042; GO:0042645; GO:0070062; GO:0070584 0 0 0 PF03129; Q9ULX7 CHOYP_CA14.1.1 m.30677 sp CAH14_HUMAN 40.925 281 148 8 11 280 1 274 1.69E-59 196 CAH14_HUMAN reviewed Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) CA14 UNQ690/PRO1335 Homo sapiens (Human) 337 bicarbonate transport [GO:0015701] GO:0004089; GO:0005886; GO:0015701; GO:0016021; GO:0046872 0 0 0 PF00194; Q9VAI1 CHOYP_LOC100123421.1.1 m.28599 sp CIA30_DROME 40.444 225 120 5 77 295 78 294 1.69E-47 164 CIA30_DROME reviewed "Complex I intermediate-associated protein 30, mitochondrial" CIA30 CG7598 Drosophila melanogaster (Fruit fly) 296 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion organization [GO:0007005]; response to heat [GO:0009408]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; response to starvation [GO:0042594]" GO:0001666; GO:0005747; GO:0006120; GO:0007005; GO:0009408; GO:0032981; GO:0042594; GO:0051082; GO:0055093 0 0 0 PF08547; A5YM72 CHOYP_CARNS1.2.6 m.3530 sp CRNS1_HUMAN 36.17 611 368 11 127 719 1 607 1.70E-108 352 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A7Y2W8 CHOYP_SC6A9.6.6 m.57818 sp SC6A9_XENLA 43.248 585 301 5 44 618 21 584 1.70E-166 493 SC6A9_XENLA reviewed Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) 633 amino acid transport [GO:0006865] GO:0005283; GO:0005328; GO:0005887; GO:0006865 0 0 0 PF00209; A7YY35 CHOYP_LOC100376186.3.7 m.23285 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 1.70E-19 98.2 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; O00461 CHOYP_GOLI4.3.4 m.29146 sp GOLI4_HUMAN 25.606 289 179 5 3 256 4 291 1.70E-12 73.2 GOLI4_HUMAN reviewed "Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)" GOLIM4 GIMPC GOLPH4 GPP130 Homo sapiens (Human) 696 transport [GO:0006810] GO:0000139; GO:0005654; GO:0005794; GO:0005796; GO:0005801; GO:0006810; GO:0010008; GO:0016020; GO:0016021; GO:0030133; GO:0030139; GO:0032580 0 0 0 0 O01393 CHOYP_LOC100533356.1.6 m.11804 sp UNC9_CAEEL 38.889 360 213 2 20 379 20 372 1.70E-95 294 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O15050 CHOYP_NEMVEDRAFT_V1G79745.1.3 m.23348 sp TRNK1_HUMAN 61.481 135 50 1 5 139 1383 1515 1.70E-52 181 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O43657 CHOYP_contig_035181 m.39961 sp TSN6_HUMAN 26.852 108 74 2 2 108 67 170 1.70E-10 58.9 TSN6_HUMAN reviewed Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6) TSPAN6 TM4SF6 UNQ767/PRO1560 Homo sapiens (Human) 245 cell surface receptor signaling pathway [GO:0007166]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005887; GO:0007166; GO:0039532; GO:0043123; GO:0070062; GO:1901223 0 0 0 PF00335; O61463 CHOYP_LOC100175959.4.7 m.28172 sp RLA2_CRYST 60.714 112 42 1 1 112 1 110 1.70E-29 105 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_87294.1.6 m.20502 sp TRIM3_RAT 26.829 123 87 2 74 194 622 743 1.70E-08 57.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P07439 CHOYP_LOC101442031.1.1 m.58274 sp LEC3_MEGRO 33.058 121 78 2 29 147 32 151 1.70E-17 77.4 LEC3_MEGRO reviewed Lectin BRA-3 0 Megabalanus rosa (Acorn barnacle) 162 0 GO:0030246 0 0 0 PF00059; P10394 CHOYP_CRE_29157.1.1 m.41743 sp POL4_DROME 30.189 265 175 5 1 263 977 1233 1.70E-30 128 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P16157 CHOYP_TNKS1.3.5 m.28972 sp ANK1_HUMAN 25.036 699 401 20 163 792 16 660 1.70E-33 143 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P30533 CHOYP_AMRP.1.1 m.36070 sp AMRP_HUMAN 41.139 316 165 9 57 358 49 357 1.70E-55 188 AMRP_HUMAN reviewed Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) LRPAP1 A2MRAP Homo sapiens (Human) 357 negative regulation of beta-amyloid clearance [GO:1900222]; negative regulation of protein binding [GO:0032091]; negative regulation of very-low-density lipoprotein particle clearance [GO:0010916]; protein folding [GO:0006457]; vesicle-mediated transport [GO:0016192] GO:0004873; GO:0005576; GO:0005783; GO:0005886; GO:0006457; GO:0008201; GO:0009986; GO:0010916; GO:0016021; GO:0016192; GO:0031982; GO:0032091; GO:0048019; GO:0048237; GO:0050750; GO:0051082; GO:0070326; GO:1900222 0 0 0 PF06401;PF06400; P34275 CHOYP_IVD.2.2 m.14522 sp IVD_CAEEL 52.163 393 187 1 40 431 6 398 1.70E-145 424 IVD_CAEEL reviewed Probable acyl-CoA dehydrogenase 6 (Probable isovaleryl-CoA dehydrogenase) (IVD) (EC 1.3.8.4) acdh-6 C02D5.1 Caenorhabditis elegans 408 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; leucine catabolic process [GO:0006552]; lipid homeostasis [GO:0055088] GO:0000062; GO:0003995; GO:0006552; GO:0009055; GO:0033539; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. 0 0 PF00441;PF02770;PF02771; P36241 CHOYP_LOC100114310.2.2 m.64228 sp RL19_DROME 74.619 197 50 0 1 197 2 198 1.70E-96 281 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P38552 CHOYP_BRAFLDRAFT_126856.1.3 m.24519 sp LEG4_RAT 40.313 320 164 8 44 346 14 323 1.70E-64 210 LEG4_RAT reviewed Galectin-4 (Gal-4) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) Lgals4 Rattus norvegicus (Rat) 324 0 GO:0005615; GO:0016936; GO:0030246 0 0 0 PF00337; P42768 CHOYP_WASP.1.1 m.35786 sp WASP_HUMAN 42.759 290 149 3 8 280 19 308 1.70E-78 257 WASP_HUMAN reviewed Wiskott-Aldrich syndrome protein (WASp) WAS IMD2 Homo sapiens (Human) 502 actin filament-based movement [GO:0030048]; actin filament polymerization [GO:0030041]; actin polymerization or depolymerization [GO:0008154]; blood coagulation [GO:0007596]; defense response [GO:0006952]; endosomal transport [GO:0016197]; epidermis development [GO:0008544]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response [GO:0006955]; negative regulation of cell motility [GO:2000146]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; protein complex assembly [GO:0006461]; regulation of T cell antigen processing and presentation [GO:0002625]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852] GO:0002625; GO:0005829; GO:0005911; GO:0006461; GO:0006952; GO:0006955; GO:0007596; GO:0008154; GO:0008544; GO:0012506; GO:0015629; GO:0016197; GO:0017124; GO:0019901; GO:0030041; GO:0030048; GO:0030695; GO:0038096; GO:0042110; GO:0042802; GO:0043274; GO:0050852; GO:0070062; GO:2000146; GO:2000601 0 0 0 PF00786;PF00568;PF02205; P49013 CHOYP_TRIADDRAFT_26633.5.6 m.55288 sp FBP3_STRPU 50.694 144 69 1 336 479 214 355 1.70E-38 150 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P79955 CHOYP_KLPA.1.1 m.50156 sp CTK2_XENLA 43.777 683 328 15 17 694 12 643 1.70E-157 472 CTK2_XENLA reviewed Carboxy-terminal kinesin 2 (XCTK2) 0 Xenopus laevis (African clawed frog) 643 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; Q04519 CHOYP_ASM.1.1 m.21521 sp ASM_MOUSE 46.578 526 273 6 93 615 85 605 1.70E-159 474 ASM_MOUSE reviewed Sphingomyelin phosphodiesterase (EC 3.1.4.12) (Acid sphingomyelinase) (aSMase) Smpd1 Asm Mus musculus (Mouse) 627 ceramide biosynthetic process [GO:0046513]; negative regulation of MAP kinase activity [GO:0043407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein dephosphorylation [GO:0035307]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; sphingomyelin catabolic process [GO:0006685]; termination of signal transduction [GO:0023021] GO:0005615; GO:0005764; GO:0005768; GO:0005886; GO:0006685; GO:0008270; GO:0016798; GO:0023021; GO:0035307; GO:0042220; GO:0042493; GO:0042599; GO:0043065; GO:0043407; GO:0046513; GO:0061750; GO:0070062 0 0 0 PF00149; Q09324 CHOYP_LOC100372744.1.2 m.838 sp GCNT1_MOUSE 36.24 367 217 5 77 426 56 422 1.70E-82 264 GCNT1_MOUSE reviewed "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)" Gcnt1 Mus musculus (Mouse) 428 cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; protein glycosylation [GO:0006486]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729] GO:0000139; GO:0003829; GO:0005615; GO:0005802; GO:0006486; GO:0009101; GO:0016021; GO:0031985; GO:0032868; GO:0048729; GO:0050901; GO:0060352; GO:0060993 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02485; Q0VD31 CHOYP_NAEGRDRAFT_77663.1.1 m.27204 sp FBXL4_BOVIN 31.073 177 88 6 11 153 51 227 1.70E-13 77 FBXL4_BOVIN reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) FBXL4 Bos taurus (Bovine) 621 0 GO:0005634; GO:0005758 0 0 0 PF00646; Q16TM5 CHOYP_LOC582981.1.1 m.63425 sp BND7A_AEDAE 75.646 271 62 1 23 293 23 289 1.70E-136 390 BND7A_AEDAE reviewed Band 7 protein AAEL010189 AAEL010189 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 297 0 GO:0016021 0 0 0 PF01145; Q29HY3 CHOYP_LOC100373506.5.8 m.40810 sp CDC42_DROPS 41.573 178 104 0 9 186 4 181 1.70E-44 149 CDC42_DROPS reviewed Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) 191 maintenance of protein location [GO:0045185]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275; GO:0045185; GO:0045860 0 0 0 PF00071; Q460N5 CHOYP_PAR14.4.17 m.32426 sp PAR14_HUMAN 32.623 1033 649 21 1 1027 809 1800 1.70E-159 518 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4VCS5 CHOYP_AMOT.1.1 m.59116 sp AMOT_HUMAN 38.677 393 207 10 282 648 416 800 1.70E-65 238 AMOT_HUMAN reviewed Angiomotin AMOT KIAA1071 Homo sapiens (Human) 1084 actin cytoskeleton organization [GO:0030036]; blood vessel endothelial cell migration [GO:0043534]; cell-cell junction assembly [GO:0007043]; cell migration involved in gastrulation [GO:0042074]; cellular protein localization [GO:0034613]; chemotaxis [GO:0006935]; establishment of cell polarity involved in ameboidal cell migration [GO:0003365]; gastrulation with mouth forming second [GO:0001702]; hippo signaling [GO:0035329]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of GTPase activity [GO:0034260]; negative regulation of vascular permeability [GO:0043116]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell size [GO:0045793]; positive regulation of embryonic development [GO:0040019]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell migration [GO:0030334]; regulation of small GTPase mediated signal transduction [GO:0051056]; vasculogenesis [GO:0001570] GO:0001570; GO:0001701; GO:0001702; GO:0001725; GO:0001726; GO:0003365; GO:0004872; GO:0005737; GO:0005829; GO:0005884; GO:0005923; GO:0006935; GO:0007043; GO:0009897; GO:0009986; GO:0016021; GO:0016525; GO:0030027; GO:0030036; GO:0030139; GO:0030334; GO:0034260; GO:0034613; GO:0035329; GO:0040019; GO:0042074; GO:0043116; GO:0043532; GO:0043534; GO:0043536; GO:0045793; GO:0051056; GO:0051496 0 0 0 PF12240; Q502K3 CHOYP_BC1G_06991.1.4 m.21046 sp ANR52_DANRE 28.784 403 265 6 2 393 5 396 1.70E-38 151 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q55E58 CHOYP_LOC100313668.5.6 m.53591 sp PATS1_DICDI 25.292 257 157 9 495 746 1793 2019 1.70E-10 68.6 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5BIW4 CHOYP_ALS2.3.3 m.44849 sp ALS2_PANTR 46.552 116 61 1 39 154 1335 1449 1.70E-24 102 ALS2_PANTR reviewed Alsin (Amyotrophic lateral sclerosis 2 protein homolog) ALS2 Pan troglodytes (Chimpanzee) 1657 "behavioral fear response [GO:0001662]; endosomal transport [GO:0016197]; locomotory behavior [GO:0007626]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; protein localization [GO:0008104]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]; vesicle organization [GO:0016050]" GO:0001662; GO:0001726; GO:0001881; GO:0005737; GO:0005769; GO:0005829; GO:0006979; GO:0007528; GO:0007626; GO:0008104; GO:0014069; GO:0016050; GO:0016197; GO:0017112; GO:0017137; GO:0030027; GO:0030425; GO:0030676; GO:0031982; GO:0035023; GO:0035249; GO:0042803; GO:0043087; GO:0043197; GO:0043234; GO:0043539; GO:0043547; GO:0045860; GO:0048812; GO:0051036 0 0 0 PF02493;PF00415;PF00621;PF02204; Q5EAE6 CHOYP_ISCW_ISCW005083.2.2 m.40344 sp DAP1_BOVIN 40.741 108 57 2 36 143 1 101 1.70E-17 75.5 DAP1_BOVIN reviewed Death-associated protein 1 (DAP-1) DAP Bos taurus (Bovine) 102 apoptotic signaling pathway [GO:0097190]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; negative regulation of autophagy [GO:0010507] GO:0006914; GO:0010507; GO:0034198; GO:0070513; GO:0097190 0 0 0 PF15228; Q5R663 CHOYP_LOC100552542.1.1 m.14816 sp KBTB3_PONAB 26.458 480 283 14 42 482 61 509 1.70E-32 135 KBTB3_PONAB reviewed Kelch repeat and BTB domain-containing protein 3 KBTBD3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 608 0 0 0 0 0 PF07707;PF00651;PF01344; Q6DFV8 CHOYP_NEMVEDRAFT_V1G214844.12.34 m.31432 sp VWDE_MOUSE 24.022 716 432 39 18 678 1 659 1.70E-16 88.6 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6DIS2 CHOYP_contig_045248 m.52574 sp CDV3_XENTR 28.079 203 103 7 65 263 78 241 1.70E-08 57.4 CDV3_XENTR reviewed Protein CDV3 homolog cdv3 TGas130k19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 244 0 GO:0005737 0 0 0 PF15359; Q6NWX7 CHOYP_NTM1A.1.1 m.614 sp NTM1A_DANRE 56.796 206 88 1 32 236 6 211 1.70E-82 248 NTM1A_DANRE reviewed N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) ntmt1 mettl11a zgc:77488 Danio rerio (Zebrafish) (Brachydanio rerio) 223 chromosome segregation [GO:0007059]; N-terminal peptidyl-alanine methylation [GO:0018011]; N-terminal peptidyl-proline dimethylation [GO:0018016]; N-terminal peptidyl-proline methylation [GO:0035568]; N-terminal peptidyl-serine dimethylation [GO:0035572]; N-terminal peptidyl-serine methylation [GO:0035570]; N-terminal peptidyl-serine trimethylation [GO:0035573]; spindle organization [GO:0007051] GO:0005634; GO:0005737; GO:0007051; GO:0007059; GO:0008276; GO:0018011; GO:0018016; GO:0035568; GO:0035570; GO:0035572; GO:0035573; GO:0071885 0 0 0 PF05891; Q6PJW8 CHOYP_TRIADDRAFT_61237.1.1 m.51829 sp CNST_HUMAN 32.773 119 74 2 137 250 160 277 1.70E-09 63.5 CNST_HUMAN reviewed Consortin CNST C1orf71 Homo sapiens (Human) 725 negative regulation of phosphatase activity [GO:0010923]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998] GO:0005802; GO:0005886; GO:0010923; GO:0016020; GO:0016021; GO:0019902; GO:0030133; GO:0042998; GO:0043234; GO:0071253 0 0 0 PF15281; Q6UB98 CHOYP_TVAG_310120.1.1 m.38256 sp ANR12_HUMAN 38.318 107 49 5 184 289 189 279 1.70E-07 56.2 ANR12_HUMAN reviewed Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) 2062 0 GO:0005654; GO:0005737 0 0 0 PF00023;PF12796; Q7T3C7 CHOYP_RTN4IP1.1.1 m.52401 sp RT4I1_DANRE 45.378 357 193 1 54 408 28 384 1.70E-113 340 RT4I1_DANRE reviewed "Reticulon-4-interacting protein 1 homolog, mitochondrial" rtn4ip1 Danio rerio (Zebrafish) (Brachydanio rerio) 387 eye photoreceptor cell development [GO:0042462]; regulation of dendrite development [GO:0050773]; retina layer formation [GO:0010842] GO:0005741; GO:0008270; GO:0010842; GO:0016491; GO:0042462; GO:0050773 0 0 0 PF08240; Q868Z9 CHOYP_DPSE_GA17283.1.3 m.456 sp PPN_DROME 33.529 683 305 17 811 1373 1490 2143 1.70E-98 359 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q8GY23 CHOYP_LOC100376147.2.2 m.15454 sp UPL1_ARATH 24.855 346 199 16 349 646 3323 3655 1.70E-06 55.5 UPL1_ARATH reviewed E3 ubiquitin-protein ligase UPL1 (Ubiquitin-protein ligase 1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase UPL1) UPL1 At1g55860 F14J16.14 F14J16.37 Arabidopsis thaliana (Mouse-ear cress) 3681 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF14377;PF06012;PF06025;PF00632;PF00627; Q8R0F3 CHOYP_LOC100568234.1.1 m.60837 sp SUMF1_MOUSE 55.679 361 148 7 3 356 15 370 1.70E-140 407 SUMF1_MOUSE reviewed Sulfatase-modifying factor 1 (EC 1.8.99.-) (C-alpha-formylglycine-generating enzyme 1) Sumf1 Fge Mus musculus (Mouse) 372 0 GO:0005783; GO:0005788; GO:0016491; GO:0042803; GO:0046872 PATHWAY: Protein modification; sulfatase oxidation. 0 0 PF03781; Q98TR7 CHOYP_RS16.1.5 m.29365 sp RS16_HETFO 89.655 145 15 0 7 151 2 146 1.70E-92 267 RS16_HETFO reviewed 40S ribosomal protein S16 rps16 Heteropneustes fossilis (Stinging catfish) 146 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00380; Q9BXF3 CHOYP_CECR2.1.3 m.2983 sp CECR2_HUMAN 59.146 164 62 2 3 166 11 169 1.70E-55 217 CECR2_HUMAN reviewed Cat eye syndrome critical region protein 2 CECR2 KIAA1740 Homo sapiens (Human) 1484 apoptotic DNA fragmentation [GO:0006309]; ATP-dependent chromatin remodeling [GO:0043044]; covalent chromatin modification [GO:0016569]; cytokinesis [GO:0000910]; cytoskeleton organization [GO:0007010]; execution phase of apoptosis [GO:0097194]; neural tube development [GO:0021915]; vesicle-mediated transport [GO:0016192] GO:0000910; GO:0005634; GO:0006309; GO:0007010; GO:0016192; GO:0016569; GO:0021915; GO:0043044; GO:0090537; GO:0097194 0 0 0 PF00439; Q9BYK8 CHOYP_LOC583716.1.4 m.2481 sp HELZ2_HUMAN 28.563 1670 1027 55 398 2001 1055 2624 1.70E-172 589 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9DGD1 CHOYP_LOC100372236.4.4 m.63101 sp MGT4C_CHICK 40.379 317 186 3 95 410 84 398 1.70E-78 253 MGT4C_CHICK reviewed "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) 464 N-glycan processing [GO:0006491] GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04666; Q9ESK9 CHOYP_RBCC1.2.2 m.46574 sp RBCC1_MOUSE 40.333 300 175 4 219 515 306 604 1.70E-60 233 RBCC1_MOUSE reviewed RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (FAK family kinase-interacting protein of 200 kDa) (FIP200) (LaXp180) Rb1cc1 Cc1 Kiaa0203 Mus musculus (Mouse) 1588 "autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cell cycle [GO:0007049]; heart development [GO:0007507]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000045; GO:0000407; GO:0001889; GO:0001934; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006914; GO:0007049; GO:0007507; GO:0019901; GO:0031965; GO:0034045; GO:0043066; GO:0045793; GO:0046330; GO:1990316; GO:2001237 0 0 0 PF10377; Q9H8W5 CHOYP_BRAFLDRAFT_98895.1.2 m.27854 sp TRI45_HUMAN 24.384 365 215 16 32 364 22 357 1.70E-15 81.6 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9JKP8 CHOYP_CHRC1.1.2 m.28863 sp CHRC1_MOUSE 54.348 92 40 1 19 108 19 110 1.70E-25 95.5 CHRC1_MOUSE reviewed Chromatin accessibility complex protein 1 (CHRAC-1) (DNA polymerase epsilon subunit p15) (NF-YC-like protein) (YC-like protein 1) (YCL1) Chrac1 Mus musculus (Mouse) 129 chromatin remodeling [GO:0006338] GO:0003677; GO:0003887; GO:0006338; GO:0008623 0 0 0 PF00808; Q9JLI6 CHOYP_SCLY.3.3 m.29360 sp SCLY_MOUSE 54.087 416 181 4 3 410 18 431 1.70E-165 474 SCLY_MOUSE reviewed Selenocysteine lyase (mSCL) (EC 4.4.1.16) Scly Scl Mus musculus (Mouse) 432 lipid metabolic process [GO:0006629]; negative regulation of cellular response to oxidative stress [GO:1900408]; response to insulin [GO:0032868]; selenium compound metabolic process [GO:0001887] GO:0001887; GO:0005829; GO:0006629; GO:0009000; GO:0016740; GO:0032868; GO:1900408 0 0 0 PF00266; Q9P2E3 CHOYP_ZNFX1.5.12 m.24579 sp ZNFX1_HUMAN 28.285 449 285 13 97 525 193 624 1.70E-41 163 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9QUN7 CHOYP_TLR2.2.7 m.36664 sp TLR2_MOUSE 38.614 101 60 2 16 114 641 741 1.70E-09 63.5 TLR2_MOUSE reviewed Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) 784 cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to peptidoglycan [GO:0071224]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; chloramphenicol transport [GO:0042892]; cytokine secretion involved in immune response [GO:0002374]; defense response to Gram-positive bacterium [GO:0050830]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; induction by symbiont of defense-related host nitric oxide production [GO:0052063]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-10 production [GO:0032613]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-17 production [GO:0032700]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of xenophagy [GO:1904417]; regulation of dendritic cell cytokine production [GO:0002730]; response to bacterium [GO:0009617]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; toll-like receptor 2 signaling pathway [GO:0034134] GO:0001530; GO:0002238; GO:0002374; GO:0002687; GO:0002730; GO:0002752; GO:0002755; GO:0004872; GO:0004888; GO:0005737; GO:0005794; GO:0005886; GO:0006954; GO:0007252; GO:0008329; GO:0009617; GO:0009897; GO:0009986; GO:0010628; GO:0016021; GO:0030177; GO:0030670; GO:0031226; GO:0032494; GO:0032613; GO:0032695; GO:0032700; GO:0032722; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0032757; GO:0032760; GO:0034123; GO:0034134; GO:0035325; GO:0035354; GO:0035355; GO:0042346; GO:0042495; GO:0042496; GO:0042497; GO:0042498; GO:0042535; GO:0042834; GO:0042892; GO:0044130; GO:0045087; GO:0045121; GO:0045429; GO:0045944; GO:0046982; GO:0050715; GO:0050729; GO:0050830; GO:0051092; GO:0051770; GO:0052063; GO:0060907; GO:0070374; GO:0070891; GO:0071221; GO:0071223; GO:0071224; GO:0071726; GO:0071727; GO:1901224; GO:1904417 0 0 0 PF13516;PF13855;PF01582; Q9QXE5 CHOYP_LOC100377982.1.1 m.43510 sp TSSP_MOUSE 36.2 500 303 9 8 496 9 503 1.70E-111 342 TSSP_MOUSE reviewed Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16) Prss16 Tssp Mus musculus (Mouse) 509 proteolysis [GO:0006508] GO:0004185; GO:0005764; GO:0005768; GO:0006508; GO:0008239; GO:0016023 0 0 0 PF05577; Q9R1R2 CHOYP_LOC100374741.55.83 m.53276 sp TRIM3_MOUSE 23.214 336 225 11 257 577 427 744 1.70E-12 73.9 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9ULJ7 CHOYP_TVAG_451090.10.13 m.64599 sp ANR50_HUMAN 28.692 237 140 6 21 233 658 889 1.70E-17 84.7 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9Z0F0 CHOYP_ISCW_ISCW010532.4.4 m.62264 sp B3GT4_MOUSE 31.734 271 144 10 148 386 73 334 1.70E-33 132 B3GT4_MOUSE reviewed "Beta-1,3-galactosyltransferase 4 (Beta-1,3-GalTase 4) (Beta3Gal-T4) (Beta3GalT4) (b3Gal-T4) (EC 2.4.1.62) (Gal-T2) (Ganglioside galactosyltransferase) (UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase)" B3galt4 Mus musculus (Mouse) 371 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0016021; GO:0047915 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; A0JM12 CHOYP_contig_003908 m.4452 sp MEG10_XENTR 37.408 409 220 19 2 400 377 759 1.71E-52 191 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A1Z6E0 CHOYP_LOC100377075.2.2 m.12166 sp GUS_DROME 36.765 136 77 3 73 201 97 230 1.71E-18 84.7 GUS_DROME reviewed Protein gustavus gus CG2944 Drosophila melanogaster (Fruit fly) 279 cuticle pattern formation [GO:0035017]; dorsal appendage formation [GO:0046843]; germ cell development [GO:0007281]; intracellular signal transduction [GO:0035556]; oocyte anterior/posterior axis specification [GO:0007314]; pole cell migration [GO:0007280]; pole plasm assembly [GO:0007315]; positive regulation of protein catabolic process [GO:0045732]; protein localization [GO:0008104]; wing disc morphogenesis [GO:0007472] GO:0005634; GO:0005737; GO:0005938; GO:0007280; GO:0007281; GO:0007314; GO:0007315; GO:0007472; GO:0008104; GO:0031466; GO:0035017; GO:0035556; GO:0045495; GO:0045732; GO:0046843; GO:0048471; GO:0070449 0 0 0 PF07525;PF00622; A4IF63 CHOYP_TRIM2.32.59 m.37531 sp TRIM2_BOVIN 27.461 193 101 7 133 312 536 702 1.71E-08 59.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7YY35 CHOYP_LOC100376186.4.7 m.56507 sp K2012_BOVIN 36.22 254 156 3 1026 1274 891 1143 1.71E-24 115 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; D2GXS7 CHOYP_LOC100369014.5.9 m.34950 sp TRIM2_AILME 26.616 263 161 10 252 494 492 742 1.71E-11 70.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O08585 CHOYP_BRAFLDRAFT_127100.2.2 m.42597 sp CLCA_MOUSE 44.361 133 55 4 17 141 28 149 1.71E-25 100 CLCA_MOUSE reviewed Clathrin light chain A (Lca) Clta Mus musculus (Mouse) 235 clathrin-mediated endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] GO:0005198; GO:0006886; GO:0016020; GO:0016023; GO:0030125; GO:0030130; GO:0030132; GO:0032050; GO:0043231; GO:0071439; GO:0072583 0 0 0 PF01086; O75382 CHOYP_BRAFLDRAFT_87331.1.4 m.20507 sp TRIM3_HUMAN 27.407 135 87 4 148 276 614 743 1.71E-08 58.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88281 CHOYP_PEAR1.5.16 m.33849 sp MEGF6_RAT 37.079 356 200 12 5 353 616 954 1.71E-47 177 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O95749 CHOYP_GGPPS.1.1 m.12124 sp GGPPS_HUMAN 69.257 296 91 0 1 296 1 296 1.71E-155 439 GGPPS_HUMAN reviewed "Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)" GGPS1 Homo sapiens (Human) 300 cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]; geranylgeranyl diphosphate biosynthetic process [GO:0033386]; isoprenoid metabolic process [GO:0006720] GO:0004161; GO:0004311; GO:0004337; GO:0005829; GO:0006695; GO:0006720; GO:0033384; GO:0033386; GO:0045337; GO:0046872 PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.; PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.; PATHWAY: Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. 0 0 PF00348; P00639 CHOYP_TRIADDRAFT_25440.1.1 m.29417 sp DNAS1_BOVIN 45.56 259 137 3 42 297 25 282 1.71E-75 235 DNAS1_BOVIN reviewed Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) DNASE1 DNL1 Bos taurus (Bovine) 282 apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308] GO:0004530; GO:0005576; GO:0005634; GO:0005635; GO:0006308; GO:0006915 0 0 0 PF03372; P21927 CHOYP_CHLE.2.3 m.29786 sp CHLE_RABIT 40.187 321 163 8 18 320 5 314 1.71E-62 211 CHLE_RABIT reviewed Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE Oryctolagus cuniculus (Rabbit) 581 0 GO:0003990; GO:0004104; GO:0005576 0 0 0 PF08674;PF00135; P23471 CHOYP_PTPRK.18.20 m.62712 sp PTPRZ_HUMAN 31.496 635 354 22 346 914 1671 2290 1.71E-72 265 PTPRZ_HUMAN reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) PTPRZ1 HTPZP2 PTPRZ PTPRZ2 PTPZ Homo sapiens (Human) 2315 axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; hematopoietic progenitor cell differentiation [GO:0002244]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; protein dephosphorylation [GO:0006470]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0002244; GO:0004725; GO:0005001; GO:0005578; GO:0005615; GO:0005737; GO:0005887; GO:0006470; GO:0007409; GO:0007413; GO:0007417; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0021766; GO:0030027; GO:0030175; GO:0030424; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; P28828 CHOYP_PTPRE.18.19 m.62693 sp PTPRM_MOUSE 32.849 551 322 14 270 787 867 1402 1.71E-74 268 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P29691 CHOYP_LOC101242512.1.1 m.48606 sp EF2_CAEEL 91.071 112 10 0 9 120 466 577 1.71E-65 216 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P30710 CHOYP_GPX5.1.1 m.44157 sp GPX5_RAT 54.237 118 47 3 1 113 97 212 1.71E-36 127 GPX5_RAT reviewed Epididymal secretory glutathione peroxidase (EC 1.11.1.9) (Epididymis-specific glutathione peroxidase-like protein) (EGLP) (Glutathione peroxidase 5) (GPx-5) (GSHPx-5) Gpx5 Rattus norvegicus (Rat) 221 response to oxidative stress [GO:0006979] GO:0004602; GO:0005576; GO:0006979 0 0 cd00340; PF00255; P36241 CHOYP_contig_054986 m.65609 sp RL19_DROME 70.968 124 35 1 1 123 76 199 1.71E-47 154 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P50882 CHOYP_LOC100368394.1.2 m.22889 sp RL9_DROME 72.441 127 29 2 14 134 60 186 1.71E-58 182 RL9_DROME reviewed 60S ribosomal protein L9 RpL9 M(2)32D CG6141 Drosophila melanogaster (Fruit fly) 190 centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052] GO:0000022; GO:0002181; GO:0003723; GO:0003735; GO:0005840; GO:0007052; GO:0019843; GO:0022625; GO:0051298 0 0 0 PF00347; P54106 CHOYP_LOC101062323.1.1 m.15918 sp ICLN_XENLA 39.407 236 117 4 14 223 3 238 1.71E-39 139 ICLN_XENLA reviewed Methylosome subunit pICln (Chloride conductance regulatory protein ICln) (I(Cln)) clns1a icln Xenopus laevis (African clawed frog) 241 cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0005634; GO:0005829; GO:0005856; GO:0005886; GO:0006821; GO:0006884; GO:0034709; GO:0034715 0 0 0 0 P55934 CHOYP_ISCW_ISCW013674.1.1 m.29802 sp CNG_ICTPU 67.265 223 72 1 1 223 414 635 1.71E-98 304 CNG_ICTPU reviewed Cyclic nucleotide-gated cation channel 0 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 682 response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608] GO:0005216; GO:0007608; GO:0016021; GO:0030552; GO:0030553; GO:0050896 0 0 0 PF16526;PF00027;PF00520; P62255 CHOYP_LOC692982.1.1 m.11651 sp UB2G1_RAT 74.699 166 41 1 16 180 1 166 1.71E-89 262 UB2G1_RAT reviewed "Ubiquitin-conjugating enzyme E2 G1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G1) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]" Ube2g1 Ubc7 Ube2g Rattus norvegicus (Rat) 170 protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0004842; GO:0005524; GO:0005737; GO:0006511; GO:0016567; GO:0031625; GO:0061630; GO:0061631; GO:0070062; GO:0070534; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; P70097 CHOYP_SDHC.1.1 m.31276 sp C560_CRIGR 48.12 133 69 0 44 176 34 166 1.71E-41 140 C560_CRIGR reviewed "Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (QPs-1) (QPs1)" SDHC Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 169 tricarboxylic acid cycle [GO:0006099] GO:0000104; GO:0005743; GO:0005749; GO:0006099; GO:0009055; GO:0016021; GO:0020037; GO:0046872 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle. 0 0 PF01127; P79345 CHOYP_AAEL_AAEL006854.1.1 m.13363 sp NPC2_BOVIN 38.816 152 83 4 1 146 1 148 1.71E-33 117 NPC2_BOVIN reviewed Epididymal secretory protein E1 (EPV20) (Niemann Pick type C2 protein homolog) NPC2 Bos taurus (Bovine) 149 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; response to virus [GO:0009615] GO:0005764; GO:0005783; GO:0008203; GO:0009615; GO:0015485; GO:0030301; GO:0032367; GO:0033344; GO:0042632; GO:0070062 0 0 0 PF02221; P83941 CHOYP_ELOC.1.1 m.1299 sp ELOC_RAT 94.495 109 6 0 11 119 4 112 1.71E-74 219 ELOC_RAT reviewed Transcription elongation factor B polypeptide 1 (Elongin 15 kDa subunit) (Elongin-C) (EloC) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Stromal membrane-associated protein SMAP1B homolog) Tceb1 Rattus norvegicus (Rat) 112 "positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0030891; GO:0032403; GO:0032968; GO:0042787; GO:0070449 0 0 0 PF03931; Q01611 CHOYP_ISCW_ISCW000803.1.1 m.45936 sp ZFY1_XENLA 28.421 285 191 7 692 964 475 758 1.71E-23 110 ZFY1_XENLA reviewed Zinc finger Y-chromosomal protein 1 (ZFY-1) zfy1 Xenopus laevis (African clawed frog) 794 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF04704; Q0EEE2 CHOYP_BRAFLDRAFT_74381.1.1 m.17751 sp PTHD3_MOUSE 24.182 856 573 21 28 836 80 906 1.71E-64 237 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q0VAA2 CHOYP_BRAFLDRAFT_87451.1.4 m.9491 sp LR74A_HUMAN 31.515 495 310 9 77 560 7 483 1.71E-64 222 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q10J94 CHOYP_CYTC.1.1 m.29500 sp CYT8_ORYSJ 38.235 102 48 4 23 116 29 123 1.71E-11 60.5 CYT8_ORYSJ reviewed Cysteine proteinase inhibitor 8 (Oryzacystatin VIII) (OC-VIII) (Oryzacystatin-8) Os03g0429000 LOC_Os03g31510 OsJ_11358 Oryza sativa subsp. japonica (Rice) 123 defense response [GO:0006952] GO:0004869; GO:0005576; GO:0006952 0 0 0 PF16845; Q4LDE5 CHOYP_LOC100367084.5.22 m.31401 sp SVEP1_HUMAN 25.328 687 415 23 242 845 435 1106 1.71E-37 159 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q502K2 CHOYP_SAMH1.2.12 m.5598 sp SAMH1_DANRE 55.292 463 193 6 17 467 95 555 1.71E-170 496 SAMH1_DANRE reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) 622 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966;PF07647; Q502M6 CHOYP_LOC100369925.1.2 m.36250 sp ANR29_DANRE 34.682 173 90 4 403 556 49 217 1.71E-17 87 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q58618 CHOYP_PHUM_PHUM302370.1.1 m.31554 sp Y1221_METJA 23.704 270 150 6 369 635 49 265 1.71E-11 69.7 Y1221_METJA reviewed Uncharacterized protein MJ1221 MJ1221 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 299 0 GO:0005886; GO:0016021 0 0 0 PF04087; Q5IS76 CHOYP_CHRNA6.2.2 m.59159 sp ACHA6_PANTR 27.95 322 212 7 10 320 18 330 1.71E-31 129 ACHA6_PANTR reviewed Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Pan troglodytes (Chimpanzee) 494 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; membrane depolarization [GO:0051899]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0014059; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0051899; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; Q5R613 CHOYP_BRAFLDRAFT_77132.2.2 m.12337 sp SNX6_PONAB 73.134 134 33 2 25 157 1 132 1.71E-63 202 SNX6_PONAB reviewed "Sorting nexin-6 [Cleaved into: Sorting nexin-6, N-terminally processed]" SNX6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 406 "intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005634; GO:0005829; GO:0006886; GO:0016023; GO:0030904; GO:0031901; GO:0034452; GO:0035091; GO:0042147; GO:0097422 0 0 0 PF00787;PF09325; Q5RDQ6 CHOYP_BRAFLDRAFT_86424.1.1 m.24452 sp ZN507_PONAB 36.052 233 106 6 869 1066 580 804 1.71E-32 140 ZN507_PONAB reviewed Zinc finger protein 507 ZNF507 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 953 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q60769 CHOYP_BRAFLDRAFT_109340.1.1 m.30107 sp TNAP3_MOUSE 25.065 774 433 23 66 760 35 740 1.71E-51 198 TNAP3_MOUSE reviewed Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 3.4.19.12) (EC 6.3.2.-) (Putative DNA-binding protein A20) (Zinc finger protein A20) Tnfaip3 Tnfip3 Mus musculus (Mouse) 775 apoptotic process [GO:0006915]; B-1 B cell homeostasis [GO:0001922]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; establishment of protein localization to vacuole [GO:0072666]; inflammatory response [GO:0006954]; marginal zone B cell differentiation [GO:0002315]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell activation [GO:0050869]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of cell death [GO:0060548]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of granuloma formation [GO:0002632]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked deubiquitination [GO:0070536]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of innate immune response [GO:0045088]; response to molecule of bacterial origin [GO:0002237]; response to muramyl dipeptide [GO:0032495]; response to wounding [GO:0009611]; tolerance induction to lipopolysaccharide [GO:0072573] GO:0001922; GO:0002020; GO:0002237; GO:0002315; GO:0002632; GO:0002634; GO:0002637; GO:0002677; GO:0003677; GO:0004842; GO:0004843; GO:0005634; GO:0005737; GO:0005764; GO:0006915; GO:0006954; GO:0008270; GO:0009611; GO:0010507; GO:0016579; GO:0016874; GO:0019900; GO:0031397; GO:0032088; GO:0032495; GO:0032691; GO:0032703; GO:0032715; GO:0032720; GO:0034115; GO:0034140; GO:0034148; GO:0035871; GO:0043124; GO:0043130; GO:0043621; GO:0045088; GO:0045732; GO:0045736; GO:0045824; GO:0048662; GO:0050728; GO:0050869; GO:0060548; GO:0070062; GO:0070301; GO:0070429; GO:0070433; GO:0070530; GO:0070536; GO:0070936; GO:0071108; GO:0071222; GO:0071947; GO:0072573; GO:0072666; GO:1902042; GO:1903364; GO:2000347; GO:2000349; GO:2000352 0 0 0 PF02338;PF01754; Q62186 CHOYP_LOC100372990.1.1 m.15018 sp SSRD_MOUSE 48 150 78 0 1113 1262 23 172 1.71E-46 167 SSRD_MOUSE reviewed Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta) Ssr4 Mus musculus (Mouse) 172 0 GO:0005789; GO:0016021; GO:0070062 0 0 0 PF05404; Q63413 CHOYP_LOC101067857.1.1 m.36995 sp DX39B_RAT 83.019 106 18 0 1 106 140 245 1.71E-59 191 DX39B_RAT reviewed Spliceosome RNA helicase Ddx39b (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein Uap56) Ddx39b Bat1 Bat1a Uap56 Rattus norvegicus (Rat) 428 "cellular response to DNA damage stimulus [GO:0006974]; liver development [GO:0001889]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of translation [GO:0045727]; positive regulation of vascular smooth muscle cell proliferation [GO:1904707]; RNA secondary structure unwinding [GO:0010501]; spliceosomal complex assembly [GO:0000245]; viral mRNA export from host cell nucleus [GO:0046784]" GO:0000245; GO:0000346; GO:0000398; GO:0001889; GO:0004004; GO:0005524; GO:0005681; GO:0005687; GO:0005688; GO:0005737; GO:0006406; GO:0006974; GO:0010501; GO:0016363; GO:0016607; GO:0017070; GO:0030621; GO:0032403; GO:0032786; GO:0043234; GO:0044822; GO:0045727; GO:0046784; GO:0061051; GO:1904707; GO:2000002; GO:2000573 0 0 0 PF00270;PF00271; Q682S0 CHOYP_LOC100373104.1.1 m.8697 sp RPT2_ARATH 25.87 460 267 16 13 430 32 459 1.71E-27 120 RPT2_ARATH reviewed Root phototropism protein 2 (BTB/POZ domain-containing protein RPT2) RPT2 At2g30520/At2g30510 T6B20.13/T6B20.14 Arabidopsis thaliana (Mouse-ear cress) 593 phototropism [GO:0009638]; protein ubiquitination [GO:0016567] GO:0004871; GO:0005634; GO:0005737; GO:0009638; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00651;PF03000; Q6DIB5 CHOYP_MEG10.85.91 m.63926 sp MEG10_MOUSE 40.268 149 80 6 1 148 258 398 1.71E-18 87.4 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6P2X9 CHOYP_AAEL_AAEL005915.1.1 m.35379 sp MOT12_XENTR 29.282 362 200 5 2 361 124 431 1.71E-45 165 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6R7K9 CHOYP_OSHV1_GP010.1.2 m.28856 sp Y014_OSHVF 98.969 194 2 0 1 194 1 194 1.71E-142 397 Y014_OSHVF reviewed Uncharacterized protein ORF14 ORF14 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 194 0 0 0 0 0 0 Q6WN34 CHOYP_CHRD.2.2 m.31062 sp CRDL2_HUMAN 37.324 142 82 6 31 170 40 176 1.71E-16 84.7 CRDL2_HUMAN reviewed Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2) CHRDL2 BNF1 CHL2 UNQ765/PRO1557 Homo sapiens (Human) 429 cartilage development [GO:0051216]; cell differentiation [GO:0030154]; ossification [GO:0001503] GO:0001503; GO:0005615; GO:0005737; GO:0030154; GO:0051216 0 0 0 PF00093; Q758X0 CHOYP_contig_003460 m.3916 sp ACS1_ASHGO 23.684 266 184 6 21 274 117 375 1.71E-10 65.1 ACS1_ASHGO reviewed Acetyl-coenzyme A synthetase 1 (EC 6.2.1.1) (Acetate--CoA ligase 1) (Acyl-activating enzyme 1) ACS1 ADR408W Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) 694 acetate fermentation [GO:0019654]; acetyl-CoA biosynthetic process from acetate [GO:0019427]; histone acetylation [GO:0016573] GO:0003987; GO:0005524; GO:0005739; GO:0005783; GO:0005829; GO:0016208; GO:0016573; GO:0016880; GO:0019427; GO:0019654 0 0 cd05966; PF16177;PF00501;PF13193; Q7L273 CHOYP_BRAFLDRAFT_57239.1.1 m.7129 sp KCTD9_HUMAN 56.22 418 154 4 1 418 1 389 1.71E-162 465 KCTD9_HUMAN reviewed BTB/POZ domain-containing protein KCTD9 KCTD9 Homo sapiens (Human) 389 protein homooligomerization [GO:0051260] GO:0051260 0 0 0 PF02214;PF11834;PF00805; Q80TY5 CHOYP_LOC100371084.2.4 m.23474 sp VP13B_MOUSE 28.734 703 451 20 1 671 441 1125 1.71E-69 250 VP13B_MOUSE reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) 4013 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q8K245 CHOYP_UVRAG.1.1 m.29585 sp UVRAG_MOUSE 37.166 487 269 9 11 492 34 488 1.71E-87 290 UVRAG_MOUSE reviewed UV radiation resistance associated protein Uvrag Uvrag1 Mus musculus (Mouse) 698 "autophagy [GO:0006914]; centrosome organization [GO:0051297]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; maintenance of Golgi location [GO:0051684]; positive regulation of autophagy [GO:0010508]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; regulation of protein serine/threonine kinase activity [GO:0071900]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; SNARE complex assembly [GO:0035493]; spindle organization [GO:0007051]; viral entry into host cell [GO:0046718]" GO:0000149; GO:0000775; GO:0005764; GO:0005769; GO:0005770; GO:0005783; GO:0005813; GO:0006281; GO:0006890; GO:0006914; GO:0007051; GO:0007059; GO:0010508; GO:0017124; GO:0030496; GO:0032465; GO:0032801; GO:0035493; GO:0043234; GO:0045335; GO:0046718; GO:0051297; GO:0051684; GO:0070418; GO:0071900; GO:0097680 0 0 0 PF10186; Q8N4P6 CHOYP_LOC100367394.1.2 m.34992 sp LRC71_HUMAN 37.094 523 289 13 73 579 47 545 1.71E-92 298 LRC71_HUMAN reviewed Leucine-rich repeat-containing protein 71 LRRC71 C1orf92 Homo sapiens (Human) 559 0 0 0 0 0 PF13516; Q8Q0U0 CHOYP_AFUA_1G01020.7.50 m.19296 sp Y045_METMA 26.923 286 172 6 15 265 69 352 1.71E-22 98.2 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q8VDC1 CHOYP_LOC100372298.1.1 m.19547 sp FYCO1_MOUSE 27.686 968 571 32 34 919 9 929 1.71E-63 243 FYCO1_MOUSE reviewed FYVE and coiled-coil domain-containing protein 1 Fyco1 Mus musculus (Mouse) 1437 plus-end-directed vesicle transport along microtubule [GO:0072383] GO:0005764; GO:0005770; GO:0005776; GO:0016020; GO:0016021; GO:0031410; GO:0043231; GO:0046872; GO:0072383 0 0 0 PF01363;PF02759; Q924T7 CHOYP_LOC100375820.1.1 m.62640 sp RNF31_MOUSE 35.469 640 356 13 1084 1719 471 1057 1.71E-110 382 RNF31_MOUSE reviewed E3 ubiquitin-protein ligase RNF31 (EC 6.3.2.-) (HOIL-1-interacting protein) (HOIP) (Putative Ariadne-like ubiquitin ligase) (PAUL) (RING finger protein 31) Rnf31 Paul Mus musculus (Mouse) 1066 CD40 signaling pathway [GO:0023035]; negative regulation of necroptotic process [GO:0060546]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; T cell receptor signaling pathway [GO:0050852] GO:0000209; GO:0004842; GO:0005829; GO:0008270; GO:0009898; GO:0016567; GO:0016874; GO:0023035; GO:0031625; GO:0035631; GO:0043123; GO:0043130; GO:0050852; GO:0051092; GO:0060546; GO:0071797; GO:0097039; GO:1903955 0 0 0 PF16678;PF01485;PF09409; Q9CQY2 CHOYP_ISCW_ISCW002750.2.3 m.24119 sp RAM_MOUSE 37.079 89 47 1 40 119 4 92 1.71E-09 55.8 RAM_MOUSE reviewed RNMT-activating mini protein (RAM) (Protein FAM103A1) Fam103a1 Mus musculus (Mouse) 119 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031] GO:0003723; GO:0005634; GO:0005845; GO:0006370; GO:0032259; GO:0036031; GO:0044822 0 0 0 PF15320; Q9CS74 CHOYP_LOC100329062.2.2 m.39235 sp ECD_MOUSE 44.672 244 131 2 9 248 11 254 1.71E-73 240 ECD_MOUSE reviewed Protein ecdysoneless homolog Ecd Mus musculus (Mouse) 641 cell proliferation [GO:0008283]; mRNA processing [GO:0006397]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; RNA splicing [GO:0008380]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0006366; GO:0006397; GO:0008283; GO:0008380; GO:0035035; GO:0045944; GO:2000045 0 0 0 PF07093; Q9D411 CHOYP_LOC100377552.1.1 m.49831 sp TSSK4_MOUSE 47.396 192 90 1 7 187 109 300 1.71E-62 200 TSSK4_MOUSE reviewed Testis-specific serine/threonine-protein kinase 4 (TSK-4) (TSSK-4) (Testis-specific kinase 4) (EC 2.7.11.1) Tssk4 Mus musculus (Mouse) 328 cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; positive regulation of CREB transcription factor activity [GO:0032793]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] GO:0000287; GO:0001669; GO:0004674; GO:0005524; GO:0005634; GO:0006468; GO:0007275; GO:0007283; GO:0030154; GO:0031514; GO:0032793; GO:0035556 0 0 0 PF00069; Q9ESK9 CHOYP_RBCC1.1.2 m.7288 sp RBCC1_MOUSE 40.333 300 175 4 219 515 306 604 1.71E-60 233 RBCC1_MOUSE reviewed RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (FAK family kinase-interacting protein of 200 kDa) (FIP200) (LaXp180) Rb1cc1 Cc1 Kiaa0203 Mus musculus (Mouse) 1588 "autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cell cycle [GO:0007049]; heart development [GO:0007507]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000045; GO:0000407; GO:0001889; GO:0001934; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006914; GO:0007049; GO:0007507; GO:0019901; GO:0031965; GO:0034045; GO:0043066; GO:0045793; GO:0046330; GO:1990316; GO:2001237 0 0 0 PF10377; Q9ESN6 CHOYP_LOC100378898.7.10 m.55027 sp TRIM2_MOUSE 27.397 219 138 9 352 559 536 744 1.71E-10 67.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H694 CHOYP_BICC1.1.1 m.22102 sp BICC1_HUMAN 67.43 393 119 4 33 419 44 433 1.71E-175 539 BICC1_HUMAN reviewed Protein bicaudal C homolog 1 (Bic-C) BICC1 Homo sapiens (Human) 974 determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; negative regulation of canonical Wnt signaling pathway [GO:0090090] GO:0005737; GO:0007368; GO:0007507; GO:0044822; GO:0090090 0 0 0 PF00013;PF00536; Q9NUD7 CHOYP_LOC100370141.1.1 m.30179 sp CT096_HUMAN 25.806 279 184 5 107 374 97 363 1.71E-13 74.3 CT096_HUMAN reviewed Uncharacterized protein C20orf96 C20orf96 Homo sapiens (Human) 363 0 0 0 0 0 PF15397; Q9NUV9 CHOYP_LOC101072002.1.1 m.38012 sp GIMA4_HUMAN 41.516 277 142 6 218 483 18 285 1.71E-62 213 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9P212 CHOYP_LOC661312.1.1 m.11277 sp PLCE1_HUMAN 28.188 447 252 11 94 506 859 1270 1.71E-34 142 PLCE1_HUMAN reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" PLCE1 KIAA1516 PLCE PPLC Homo sapiens (Human) 2302 activation of MAPK activity [GO:0000187]; calcium-mediated signaling [GO:0019722]; cell proliferation [GO:0008283]; cytoskeleton organization [GO:0007010]; diacylglycerol biosynthetic process [GO:0006651]; epidermal growth factor receptor signaling pathway [GO:0007173]; glomerulus development [GO:0032835]; heart development [GO:0007507]; inositol phosphate-mediated signaling [GO:0048016]; inositol phosphate metabolic process [GO:0043647]; lipid catabolic process [GO:0016042]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; phospholipid metabolic process [GO:0006644]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; regulation of protein kinase activity [GO:0045859]; regulation of Ras protein signal transduction [GO:0046578]; regulation of smooth muscle contraction [GO:0006940] GO:0000139; GO:0000187; GO:0001558; GO:0004435; GO:0004629; GO:0005057; GO:0005085; GO:0005737; GO:0005829; GO:0005886; GO:0006644; GO:0006651; GO:0006940; GO:0007010; GO:0007173; GO:0007200; GO:0007204; GO:0007205; GO:0007265; GO:0007507; GO:0008277; GO:0008283; GO:0016042; GO:0017016; GO:0019722; GO:0019899; GO:0032835; GO:0043647; GO:0045859; GO:0046578; GO:0048016 0 0 0 PF00168;PF09279;PF00388;PF00387;PF00788;PF00617; Q9QYP1 CHOYP_LOC578656.15.15 m.65996 sp LRP4_RAT 26.644 867 555 26 119 944 821 1647 1.71E-81 296 LRP4_RAT reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0034185; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q9R1R2 CHOYP_BRAFLDRAFT_85511.21.23 m.60946 sp TRIM3_MOUSE 23.372 261 171 6 276 525 489 731 1.71E-10 67.4 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U3P2 CHOYP_CNTN1.2.2 m.36868 sp SYG2_CAEEL 30.496 141 81 6 248 373 227 365 1.71E-06 53.9 SYG2_CAEEL reviewed Synaptogenesis protein syg-2 (Synaptogenesis abnormal protein 2) syg-2 C26G2.1 Caenorhabditis elegans 1270 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; collateral sprouting [GO:0048668]; protein localization to synapse [GO:0035418]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007155; GO:0007267; GO:0007416; GO:0008039; GO:0030054; GO:0035418; GO:0042803; GO:0045202; GO:0048668; GO:0050808; GO:0050839 0 0 0 PF08205;PF00041;PF07679; Q9U3V5 CHOYP_TIPT.1.1 m.44072 sp TIPT_DROME 27.027 370 148 11 241 518 303 642 1.71E-24 114 TIPT_DROME reviewed Protein tiptop tio CG12630 Drosophila melanogaster (Fruit fly) 1024 "compound eye development [GO:0048749]; epidermis morphogenesis [GO:0048730]; Malpighian tubule stellate cell differentiation [GO:0061330]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; specification of segmental identity, head [GO:0007380]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001078; GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0007380; GO:0046872; GO:0048730; GO:0048749; GO:0061330 0 0 0 PF12756;PF13912; Q9UBC9 CHOYP_LOC100732161.1.1 m.47696 sp SPRR3_HUMAN 36.082 97 62 0 3 99 39 135 1.71E-14 68.2 SPRR3_HUMAN reviewed Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin) SPRR3 SPRC Homo sapiens (Human) 169 epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; wound healing [GO:0042060] GO:0001533; GO:0005198; GO:0005737; GO:0008544; GO:0018149; GO:0030216; GO:0031424; GO:0042060; GO:0070062 0 0 0 0 Q9VGG5 CHOYP_PHUM_PHUM596890.1.1 m.10989 sp CAD87_DROME 30.945 1228 762 24 589 1767 625 1815 1.71E-145 501 CAD87_DROME reviewed Cadherin-87A Cad87A CG6977 Drosophila melanogaster (Fruit fly) 1975 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005887; GO:0007156; GO:0016339; GO:0044331 0 0 0 PF00028; Q9WTR0 CHOYP_LOC100369384.1.1 m.47986 sp MMP16_MOUSE 34.535 527 294 16 33 540 38 532 1.71E-81 269 MMP16_MOUSE reviewed Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) Mmp16 Mus musculus (Mouse) 607 bone development [GO:0060348]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; ossification [GO:0001503] GO:0001503; GO:0001958; GO:0004222; GO:0005509; GO:0005886; GO:0008270; GO:0016021; GO:0030574; GO:0031012; GO:0035988; GO:0048701; GO:0060348; GO:0097094 0 0 cd04278; PF11857;PF00045;PF00413;PF01471; Q9Y283 CHOYP_LOC581491.1.2 m.56125 sp INVS_HUMAN 31.174 494 284 12 20 504 161 607 1.71E-46 187 INVS_HUMAN reviewed Inversin (Inversion of embryo turning homolog) (Nephrocystin-2) INVS INV NPHP2 Homo sapiens (Human) 1065 multicellular organism development [GO:0007275]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005737; GO:0005819; GO:0005874; GO:0005929; GO:0007275; GO:0016020; GO:0016055; GO:0090090 0 0 0 PF00023;PF12796;PF00612; B1H1P9 CHOYP_PPAL.1.2 m.3041 sp PPAL_XENLA 37.907 430 232 15 4 425 5 407 1.72E-75 245 PPAL_XENLA reviewed Lysosomal acid phosphatase (LAP) (EC 3.1.3.2) acp2 Xenopus laevis (African clawed frog) 432 0 GO:0003993; GO:0005765; GO:0016021; GO:0043202 0 0 cd07061; PF00328; B1WB06 CHOYP_LOC100185431.1.1 m.43063 sp MET24_XENTR 29.605 152 91 5 174 319 148 289 1.72E-12 71.2 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; B2RPV6 CHOYP_LOC100691700.1.2 m.60652 sp MMRN1_MOUSE 30.075 133 80 5 79 205 1082 1207 1.72E-06 51.2 MMRN1_MOUSE reviewed Multimerin-1 Mmrn1 Mus musculus (Mouse) 1210 blood coagulation [GO:0007596] GO:0005509; GO:0005576; GO:0007596 0 0 0 PF00386;PF00008;PF07546; B4GD14 CHOYP_BRAFLDRAFT_109205.4.5 m.24518 sp LPHN_DROPE 38.739 111 66 2 20 130 1 109 1.72E-19 86.7 LPHN_DROPE reviewed Latrophilin Cirl Cirl GL10904 Drosophila persimilis (Fruit fly) 1684 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021; GO:0030246 0 0 0 PF16489;PF02140;PF01825; D3YXG0 CHOYP_HMCN2.2.12 m.9692 sp HMCN1_MOUSE 25.534 1778 1097 73 319 2036 480 2090 1.72E-104 380 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O02827 CHOYP_LOC100367089.1.4 m.1391 sp MYLK_SHEEP 36.607 112 70 1 384 495 311 421 1.72E-15 82.8 MYLK_SHEEP reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) 438 0 GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0030027; GO:0032154; GO:0046872 0 0 0 PF07679;PF00069; O70277 CHOYP_BRAFLDRAFT_87308.1.2 m.23958 sp TRIM3_RAT 25.641 156 109 3 25 178 593 743 1.72E-09 60.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_79377.5.30 m.21330 sp TRIM3_HUMAN 28.182 110 71 3 198 299 622 731 1.72E-06 53.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0CI75 CHOYP_BIRA.1.1 m.18343 sp BIRA_BACSU 26.238 202 132 6 13 211 77 264 1.72E-12 72 BIRA_BACSU reviewed Bifunctional ligase/repressor BirA (Biotin--[acetyl-CoA-carboxylase] ligase) (EC 6.3.4.15) (Biotin--protein ligase) (Biotin-[acetyl-CoA carboxylase] synthetase) birA BSU22440 Bacillus subtilis (strain 168) 325 "protein biotinylation [GO:0009305]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004077; GO:0005524; GO:0006351; GO:0006355; GO:0009305 0 0 0 PF02237;PF03099;PF08279; P16157 CHOYP_TVAG_020440.20.21 m.54164 sp ANK1_HUMAN 37.349 249 156 0 4 252 255 503 1.72E-44 163 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17972 CHOYP_KCNAW.1.1 m.8389 sp KCNAW_DROME 36.645 453 238 9 153 588 4 424 1.72E-90 293 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P18700 CHOYP_TBB.6.7 m.64496 sp TBB_STRPU 93.897 213 13 0 1 213 9 221 1.72E-152 427 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P27081 CHOYP_LOC100633390.2.5 m.22144 sp ADT2_SOLTU 67.164 67 22 0 7 73 84 150 1.72E-26 103 ADT2_SOLTU reviewed "ADP,ATP carrier protein, mitochondrial (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT) (Fragment)" ANT1 AAC Solanum tuberosum (Potato) 386 transmembrane transport [GO:0055085] GO:0005215; GO:0005743; GO:0016021; GO:0055085 0 0 0 PF00153; P30568 CHOYP_BRAFLDRAFT_75371.1.1 m.20172 sp GSTA_PLEPL 44.954 218 117 3 30 246 1 216 1.72E-61 196 GSTA_PLEPL reviewed Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta) 0 Pleuronectes platessa (European plaice) 225 0 GO:0004364; GO:0005737 0 0 0 PF14497;PF13417; P31809 CHOYP_BRAFLDRAFT_74469.2.3 m.46239 sp CEAM1_MOUSE 28.448 232 134 9 135 352 68 281 1.72E-07 57.8 CEAM1_MOUSE reviewed Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a) Ceacam1 Bgp Bgp1 Mus musculus (Mouse) 521 "bile acid and bile salt transport [GO:0015721]; blood vessel development [GO:0001568]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell-cell junction organization [GO:0045216]; cellular response to insulin stimulus [GO:0032869]; common myeloid progenitor cell proliferation [GO:0035726]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; insulin catabolic process [GO:1901143]; insulin receptor internalization [GO:0038016]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation by host of viral process [GO:0044793]; negative regulation of bone resorption [GO:0045779]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of JNK cascade [GO:0046329]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; Peyer's patch development [GO:0048541]; positive regulation by host of viral process [GO:0044794]; positive regulation of activation-induced cell death of T cells [GO:0070237]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of vasculogenesis [GO:2001214]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell growth [GO:0001558]; regulation of endothelial cell differentiation [GO:0045601]; regulation of endothelial cell migration [GO:0010594]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of homophilic cell adhesion [GO:1903385]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; regulation of sprouting angiogenesis [GO:1903670]; viral entry into host cell [GO:0046718]; wound healing, spreading of cells [GO:0044319]" GO:0001558; GO:0001568; GO:0001618; GO:0001818; GO:0001915; GO:0002859; GO:0005130; GO:0005615; GO:0005886; GO:0005911; GO:0005912; GO:0006469; GO:0007156; GO:0009897; GO:0009925; GO:0009986; GO:0010594; GO:0014066; GO:0015125; GO:0015721; GO:0016020; GO:0016021; GO:0016324; GO:0016328; GO:0016338; GO:0016339; GO:0019900; GO:0019903; GO:0030054; GO:0030853; GO:0031005; GO:0031526; GO:0032692; GO:0032703; GO:0032869; GO:0035325; GO:0035726; GO:0038016; GO:0038158; GO:0042058; GO:0042102; GO:0042130; GO:0042803; GO:0043116; GO:0043318; GO:0043406; GO:0044319; GO:0044793; GO:0044794; GO:0044828; GO:0045216; GO:0045601; GO:0045671; GO:0045717; GO:0045779; GO:0046329; GO:0046330; GO:0046718; GO:0046790; GO:0046983; GO:0048541; GO:0050860; GO:0051024; GO:0051055; GO:0051533; GO:0060170; GO:0060312; GO:0070062; GO:0070237; GO:0070372; GO:0090331; GO:1901143; GO:1903385; GO:1903670; GO:1990782; GO:2000346; GO:2000516; GO:2000563; GO:2001187; GO:2001214 0 0 0 PF13895;PF07686; P34416 CHOYP_LOC663855.5.5 m.51312 sp LASP1_CAEEL 35.443 237 131 5 4 227 95 322 1.72E-36 134 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P48416 CHOYP_LOC100376649.2.4 m.38851 sp CP10_LYMST 30.172 116 74 3 1 109 190 305 1.72E-09 57.4 CP10_LYMST reviewed Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 545 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037 0 0 0 PF00067; P63018 CHOYP_HSC70.1.1 m.333 sp HSP7C_RAT 91.213 239 21 0 1 239 314 552 1.72E-154 447 HSP7C_RAT reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) Hspa8 Hsc70 Hsc73 Rattus norvegicus (Rat) 646 "aging [GO:0007568]; axo-dendritic transport [GO:0008088]; cellular protein complex disassembly [GO:0043624]; cellular response to cadmium ion [GO:0071276]; cellular response to heat [GO:0034605]; cerebellum development [GO:0021549]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; chaperone-mediated protein folding [GO:0061077]; chaperone mediated protein folding requiring cofactor [GO:0051085]; chaperone-mediated protein transport involved in chaperone-mediated autophagy [GO:0061741]; clathrin coat disassembly [GO:0072318]; estrous cycle [GO:0044849]; forebrain development [GO:0030900]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular protein transmembrane import [GO:0044743]; kidney development [GO:0001822]; mRNA processing [GO:0006397]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of catalytic activity [GO:0043085]; positive regulation of gene expression [GO:0010628]; positive regulation of lysosomal membrane permeability [GO:0097214]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein refolding [GO:1904592]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein refolding [GO:0042026]; regulation of protein complex stability [GO:0061635]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to nickel cation [GO:0010045]; response to odorant [GO:1990834]; response to progesterone [GO:0032570]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; sensory perception of smell [GO:0007608]; skeletal muscle tissue development [GO:0007519]; slow axonal transport [GO:1990832]; transcription, DNA-templated [GO:0006351]" GO:0000082; GO:0000974; GO:0001822; GO:0001916; GO:0001917; GO:0003723; GO:0005102; GO:0005524; GO:0005634; GO:0005681; GO:0005730; GO:0005737; GO:0005764; GO:0005765; GO:0005776; GO:0005829; GO:0005874; GO:0005882; GO:0005886; GO:0006351; GO:0006397; GO:0006606; GO:0007519; GO:0007568; GO:0007608; GO:0008021; GO:0008088; GO:0008134; GO:0008380; GO:0009408; GO:0009986; GO:0010045; GO:0010628; GO:0010667; GO:0014069; GO:0014823; GO:0016887; GO:0019899; GO:0021549; GO:0030424; GO:0030425; GO:0030529; GO:0030900; GO:0031686; GO:0032279; GO:0032355; GO:0032570; GO:0034605; GO:0042026; GO:0042277; GO:0042470; GO:0042493; GO:0042594; GO:0042623; GO:0043005; GO:0043025; GO:0043085; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0043234; GO:0043531; GO:0043624; GO:0044743; GO:0044849; GO:0045121; GO:0045471; GO:0045862; GO:0045892; GO:0046777; GO:0048471; GO:0050766; GO:0051082; GO:0051085; GO:0061077; GO:0061635; GO:0061684; GO:0061741; GO:0070062; GO:0071276; GO:0072318; GO:0097214; GO:1903206; GO:1904592; GO:1904593; GO:1904764; GO:1990124; GO:1990832; GO:1990833; GO:1990834; GO:1990836 0 0 0 PF00012; P82094 CHOYP_LOC580687.1.1 m.1044 sp TMF1_HUMAN 46.779 652 331 9 647 1292 447 1088 1.72E-163 520 TMF1_HUMAN reviewed TATA element modulatory factor (TMF) (Androgen receptor coactivator 160 kDa protein) (Androgen receptor-associated protein of 160 kDa) TMF1 ARA160 Homo sapiens (Human) 1093 "acrosome assembly [GO:0001675]; cellular response to organic cyclic compound [GO:0071407]; defense response to bacterium [GO:0042742]; Leydig cell differentiation [GO:0033327]; luteinizing hormone secretion [GO:0032275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; positive regulation of cytokine production [GO:0001819]; positive regulation of testosterone secretion [GO:2000845]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of transcription, DNA-templated [GO:0006355]; spermatid nucleus differentiation [GO:0007289]; sperm motility [GO:0030317]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000139; GO:0001675; GO:0001819; GO:0003677; GO:0003712; GO:0005634; GO:0005783; GO:0005794; GO:0005829; GO:0006355; GO:0006366; GO:0007289; GO:0010629; GO:0030317; GO:0032275; GO:0033327; GO:0042742; GO:0043066; GO:0061136; GO:0071407; GO:2000845 0 0 0 PF12329;PF12325; P86221 CHOYP_LOC100366728.1.1 m.57456 sp TBB4B_MESAU 95.89 73 3 0 1 73 1 73 1.72E-47 155 TBB4B_MESAU reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) 290 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091; Q08CH8 CHOYP_LOC100647659.1.1 m.41849 sp CYHR1_DANRE 64.957 117 39 2 34 148 59 175 1.72E-44 152 CYHR1_DANRE reviewed Cysteine and histidine-rich protein 1 cyhr1 zgc:153061 Danio rerio (Zebrafish) (Brachydanio rerio) 375 0 GO:0005737; GO:0008270 0 0 0 0 Q0VGY8 CHOYP_LOC756822.1.1 m.32722 sp TANC1_MOUSE 45.631 103 56 0 1 103 1113 1215 1.72E-22 93.6 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q12802 CHOYP_AKP13.2.5 m.24403 sp AKP13_HUMAN 34.5 200 125 4 17 214 29 224 1.72E-24 104 AKP13_HUMAN reviewed A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) 2813 adrenergic receptor signaling pathway [GO:0071875]; adrenergic receptor signaling pathway involved in heart process [GO:0086023]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; nuclear export [GO:0051168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cardiac muscle hypertrophy [GO:0010611]; regulation of glucocorticoid mediated signaling pathway [GO:1900169]; regulation of protein kinase activity [GO:0045859]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004691; GO:0004871; GO:0005078; GO:0005085; GO:0005089; GO:0005634; GO:0005737; GO:0005829; GO:0005938; GO:0007186; GO:0007507; GO:0010611; GO:0016020; GO:0017048; GO:0032947; GO:0035025; GO:0035556; GO:0043065; GO:0043123; GO:0045859; GO:0046872; GO:0048471; GO:0051018; GO:0051056; GO:0051168; GO:0055007; GO:0060297; GO:0060348; GO:0071875; GO:0086023; GO:1900169 0 0 0 PF00169;PF00621;PF10522; Q16534 CHOYP_PHUM_PHUM361070.1.1 m.11989 sp HLF_HUMAN 56.164 73 32 0 170 242 219 291 1.72E-19 88.2 HLF_HUMAN reviewed Hepatic leukemia factor HLF Homo sapiens (Human) 295 multicellular organism development [GO:0007275]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000977; GO:0001077; GO:0003677; GO:0003690; GO:0005634; GO:0006366; GO:0007275; GO:0035914; GO:0048511 0 0 0 PF07716; Q17QJ5 CHOYP_LOC100374248.4.5 m.57034 sp TSN5_BOVIN 27.329 161 108 3 67 227 14 165 1.72E-14 75.1 TSN5_BOVIN reviewed Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) 268 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007166; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q2KHS5 CHOYP_MOGT1.1.1 m.37061 sp MOG2A_XENLA 51.642 335 162 0 5 339 1 335 1.72E-128 374 MOG2A_XENLA reviewed 2-acylglycerol O-acyltransferase 2-A (EC 2.3.1.22) (Acyl-CoA:monoacylglycerol acyltransferase 2-A) (MGAT2-A) (Monoacylglycerol O-acyltransferase 2-A) mogat2-a Xenopus laevis (African clawed frog) 335 glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432] GO:0003846; GO:0005789; GO:0006071; GO:0016021; GO:0019432 PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. 0 0 PF03982; Q2VY69 CHOYP_ZN284.1.1 m.46399 sp ZN284_HUMAN 38.793 116 68 2 104 217 282 396 1.72E-16 81.3 ZN284_HUMAN reviewed Zinc finger protein 284 ZNF284 ZNF284L Homo sapiens (Human) 593 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q3UJP5 CHOYP_LOC100369489.1.1 m.62372 sp CH037_MOUSE 40.476 210 91 5 1 177 1 209 1.72E-44 149 CH037_MOUSE reviewed Protein C8orf37 homolog 0 Mus musculus (Mouse) 209 0 GO:0005737; GO:0005886; GO:0030054 0 0 0 PF14996; Q4R744 CHOYP_LOC753178.1.2 m.9161 sp HEAT9_MACFA 28.746 327 221 7 734 1055 142 461 1.72E-26 119 HEAT9_MACFA reviewed Protein HEATR9 (HEAT repeat-containing protein 9) HEATR9 QtsA-16377 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 570 0 0 0 0 0 0 Q52MA5 CHOYP_LOC100377702.1.1 m.57555 sp MID51_XENTR 26.573 143 96 4 220 362 310 443 1.72E-07 56.6 MID51_XENTR reviewed Mitochondrial dynamics protein MID51 (Mitochondrial dynamics protein of 51 kDa homolog) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) mief1 mid51 smcr7l Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 463 positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314] GO:0000166; GO:0005739; GO:0005741; GO:0016021; GO:0090141; GO:0090314 0 0 0 PF03281; Q54KA7 CHOYP_AFUA_1G01020.47.50 m.65368 sp SECG_DICDI 35.759 481 288 4 18 496 66 527 1.72E-71 248 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5F349 CHOYP_LOC100560387.1.1 m.26824 sp SG196_CHICK 43.233 266 135 10 57 311 48 308 1.72E-62 204 SG196_CHICK reviewed Protein O-mannose kinase (POMK) (EC 2.7.1.-) (Protein kinase-like protein SgK196) (Sugen kinase 196) POMK SGK196 RCJMB04_34j1 Gallus gallus (Chicken) 353 carbohydrate phosphorylation [GO:0046835]; protein O-linked glycosylation [GO:0006493] GO:0004672; GO:0005524; GO:0005789; GO:0006493; GO:0016021; GO:0016773; GO:0019200; GO:0046835 0 0 0 PF07714; Q5SNX7 CHOYP_LOC100376265.2.4 m.5662 sp GALC_DANRE 44.966 298 147 9 1 293 302 587 1.72E-75 247 GALC_DANRE reviewed Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc galca si:ch211-199l3.4 zgc:92561 Danio rerio (Zebrafish) (Brachydanio rerio) 660 carbohydrate metabolic process [GO:0005975]; galactosylceramide catabolic process [GO:0006683] GO:0004336; GO:0005764; GO:0005975; GO:0006683 0 0 0 PF02057; Q5UR67 CHOYP_contig_042078 m.48332 sp RIBX_MIMIV 45.122 164 79 3 301 453 2 165 1.72E-34 130 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q68ED3 CHOYP_LOC552662.1.1 m.15078 sp PAPD5_MOUSE 65.676 370 112 3 72 428 79 446 1.72E-165 491 PAPD5_MOUSE reviewed Non-canonical poly(A) RNA polymerase PAPD5 (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) Papd5 Mus musculus (Mouse) 633 cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; mitotic nuclear division [GO:0007067]; mRNA processing [GO:0006397]; rRNA processing [GO:0006364] GO:0003677; GO:0003887; GO:0004652; GO:0005730; GO:0005737; GO:0006364; GO:0006397; GO:0007067; GO:0044822; GO:0046872; GO:0051301; GO:0071044 0 0 0 PF01909;PF03828; Q6ZNA5 CHOYP_LOC100536707.1.1 m.28257 sp FRRS1_HUMAN 31.367 373 225 13 20 381 191 543 1.72E-51 186 FRRS1_HUMAN reviewed Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 SDFR2 SDR2 Homo sapiens (Human) 592 0 GO:0000293; GO:0016021; GO:0046872 0 0 cd08544; PF03351;PF02014; Q7T392 CHOYP_LOC100187278.1.2 m.49513 sp T179B_DANRE 25.837 209 137 7 19 224 18 211 1.72E-11 64.7 T179B_DANRE reviewed Transmembrane protein 179B tmem179b zgc:110591 Danio rerio (Zebrafish) (Brachydanio rerio) 219 0 GO:0016021 0 0 0 0 Q8BGC3 CHOYP_LOC100875169.1.1 m.3152 sp MOT12_MOUSE 36 200 123 1 30 224 13 212 1.72E-36 146 MOT12_MOUSE reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) Slc16a12 Mct12 Mus musculus (Mouse) 486 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q8C2L6 CHOYP_T161B.1.1 m.43724 sp T161B_MOUSE 46.061 495 250 7 1 492 1 481 1.72E-148 436 T161B_MOUSE reviewed Transmembrane protein 161B Tmem161b Mus musculus (Mouse) 487 0 GO:0016021 0 0 0 PF10268; Q8CDF7 CHOYP_DSEC_GM15515.1.1 m.30587 sp EXD1_MOUSE 29.814 161 109 4 41 199 149 307 1.72E-10 66.6 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q8NE09 CHOYP_TRIADDRAFT_64391.2.3 m.45596 sp RGS22_HUMAN 37.5 96 54 1 1094 1189 1045 1134 1.72E-12 76.3 RGS22_HUMAN reviewed Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) 1264 negative regulation of signal transduction [GO:0009968] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0009968 0 0 0 PF00615; Q8NI36 CHOYP_PLK1.2.2 m.39816 sp WDR36_HUMAN 56.311 103 45 0 1 103 608 710 1.72E-37 138 WDR36_HUMAN reviewed WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP) WDR36 Homo sapiens (Human) 951 regulation of axon extension [GO:0030516]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; rRNA processing [GO:0006364]; visual perception [GO:0007601] GO:0001895; GO:0005654; GO:0005730; GO:0006364; GO:0007601; GO:0030516; GO:0032040; GO:0044822; GO:0050896 0 0 0 PF12894;PF04192;PF00400; Q96RW7 CHOYP_HMCN1.2.44 m.4650 sp HMCN1_HUMAN 37.931 232 106 7 9 204 4528 4757 1.72E-38 145 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99996 CHOYP_LOC100368547.32.40 m.45299 sp AKAP9_HUMAN 37.864 103 55 2 41 138 3587 3685 1.72E-10 62.8 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9DFQ7 CHOYP_CCDC6.1.1 m.13919 sp RL24_GILMI 68.75 160 43 2 20 175 1 157 1.72E-69 210 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9ESB5 CHOYP_BRAFLDRAFT_124536.1.2 m.10835 sp NECA1_RAT 34.821 336 195 6 1 321 24 350 1.72E-64 210 NECA1_RAT reviewed N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) (Neuronal calcium-binding protein 1) (Synaptotagmin-interacting protein 1) (Stip-1) Necab1 Efcbp1 Stip Rattus norvegicus (Rat) 352 0 GO:0005509; GO:0005654; GO:0005737 0 0 0 PF03992;PF13833; Q9FT72 CHOYP_LOC100638433.1.1 m.59777 sp RQL3_ARATH 33.476 233 120 7 34 265 37 235 1.72E-26 114 RQL3_ARATH reviewed ATP-dependent DNA helicase Q-like 3 (EC 3.6.4.12) (RecQ-like protein 3) (AtRecQ3) (AtRecQl3) RECQL3 RECQ3 RQL3 At4g35740 F8D20.250 Arabidopsis thaliana (Mouse-ear cress) 713 DNA recombination [GO:0006310]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0003677; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006310; GO:0008026; GO:0009378; GO:0036310; GO:0043138; GO:0043140; GO:0046872 0 0 0 PF00270;PF00271;PF16124; Q9HAR2 CHOYP_SERPINB3.2.2 m.54289 sp AGRL3_HUMAN 26.939 709 435 26 516 1185 506 1170 1.72E-56 219 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9NS37 CHOYP_BRAFLDRAFT_126962.1.1 m.9076 sp ZHANG_HUMAN 44.03 134 63 3 218 342 219 349 1.72E-24 105 ZHANG_HUMAN reviewed CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) CREBZF ZF Homo sapiens (Human) 354 "negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; response to virus [GO:0009615]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0009615; GO:0042802; GO:0043565; GO:0045814; GO:0045892; GO:0051090 0 0 0 PF00170; Q9NW07 CHOYP_LOC100538157.2.2 m.48938 sp ZN358_HUMAN 31.498 327 204 3 49 373 148 456 1.72E-50 182 ZN358_HUMAN reviewed Zinc finger protein 358 ZNF358 Homo sapiens (Human) 568 "embryonic forelimb morphogenesis [GO:0035115]; neural tube development [GO:0021915]; regulation of transcription, DNA-templated [GO:0006355]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0019827; GO:0021915; GO:0035115; GO:0046872 0 0 0 PF00096;PF13912; Q9NZ63 CHOYP_BRAFLDRAFT_63995.1.2 m.10973 sp CI078_HUMAN 51.93 285 125 6 12 287 8 289 1.72E-82 253 CI078_HUMAN reviewed Uncharacterized protein C9orf78 (Hepatocellular carcinoma-associated antigen 59) C9orf78 HCA59 Homo sapiens (Human) 289 0 GO:0005654; GO:0005737 0 0 0 PF07052; Q9R1R2 CHOYP_BRAFLDRAFT_205965.28.43 m.52664 sp TRIM3_MOUSE 25.984 127 87 3 116 240 622 743 1.72E-06 53.1 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9R1R2 CHOYP_TRIM2.1.59 m.397 sp TRIM3_MOUSE 26.238 202 120 9 290 478 536 721 1.72E-06 54.3 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U489 CHOYP_LOC582174.6.16 m.32836 sp LIN41_CAEEL 30.851 94 61 2 14 104 827 919 1.72E-07 52 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9VZZ9 CHOYP_ISCW_ISCW017526.2.2 m.57044 sp DOS_DROME 37.671 146 62 5 7 148 4 124 1.72E-18 93.6 DOS_DROME reviewed Protein daughter of sevenless dos CG1044 Drosophila melanogaster (Fruit fly) 878 "anterior/posterior axis specification, embryo [GO:0008595]; antimicrobial humoral response [GO:0019730]; photoreceptor cell development [GO:0042461]; regulation of Ras protein signal transduction [GO:0046578]; sevenless signaling pathway [GO:0045500]; torso signaling pathway [GO:0008293]; wing disc development [GO:0035220]" GO:0005070; GO:0005737; GO:0005886; GO:0008293; GO:0008595; GO:0019730; GO:0035220; GO:0042169; GO:0042461; GO:0045500; GO:0046578 0 0 0 PF00169; Q9Y493 CHOYP_CBG11139.1.2 m.27119 sp ZAN_HUMAN 34.225 187 96 4 198 369 545 719 1.72E-09 64.3 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; Q9Z173 CHOYP_LPHN3.2.4 m.42331 sp AGRL3_RAT 27.549 657 408 22 249 862 575 1206 1.72E-50 197 AGRL3_RAT reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) Adgrl3 Cirl3 Cl3 Lphn3 Rattus norvegicus (Rat) 1550 brain development [GO:0007420]; cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; neuron migration [GO:0001764]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007416; GO:0007420; GO:0030246; GO:0030424; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; A4IF63 CHOYP_BRAFLDRAFT_109861.1.2 m.20505 sp TRIM2_BOVIN 22.449 147 107 3 44 188 602 743 1.73E-06 51.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_205965.27.43 m.46283 sp TRIM2_BOVIN 24.476 143 107 1 154 296 602 743 1.73E-07 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_METFOR_0399.2.2 m.66350 sp TRIM2_BOVIN 23.529 153 106 2 244 395 602 744 1.73E-07 57 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6H7G2 CHOYP_LOC100374625.1.1 m.48418 sp DBNL_BOVIN 37.5 312 169 3 32 343 1 286 1.73E-63 212 DBNL_BOVIN reviewed Drebrin-like protein DBNL Bos taurus (Bovine) 423 adaptive immune response [GO:0002250]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898]; ruffle assembly [GO:0097178]; synapse assembly [GO:0007416] GO:0000139; GO:0001726; GO:0002102; GO:0002250; GO:0005769; GO:0005829; GO:0005886; GO:0005938; GO:0006898; GO:0007416; GO:0016601; GO:0030027; GO:0030054; GO:0030665; GO:0045202; GO:0048812; GO:0051015; GO:0070062; GO:0071800; GO:0097178 0 0 0 PF00241;PF00018; B4JG34 CHOYP_BRAFLDRAFT_124027.2.2 m.50286 sp TMEDE_DROGR 69.159 214 65 1 4 216 3 216 1.73E-115 331 TMEDE_DROGR reviewed Transmembrane emp24 domain-containing protein eca eca GH18190 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) 216 dorsal/ventral pattern formation [GO:0009953]; transport [GO:0006810] GO:0005789; GO:0006810; GO:0009953; GO:0016021 0 0 0 PF01105; D2GXS7 CHOYP_BRAFLDRAFT_205965.5.43 m.13236 sp TRIM2_AILME 25 152 113 1 28 179 593 743 1.73E-08 60.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F7H9X2 CHOYP_BRAFLDRAFT_213530.1.3 m.1075 sp TRIM2_CALJA 24.074 216 149 4 230 441 540 744 1.73E-09 63.5 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O54698 CHOYP_MPI.1.1 m.35644 sp S29A1_RAT 30.176 454 259 10 68 470 4 450 1.73E-54 192 S29A1_RAT reviewed "Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)" Slc29a1 Ent1 Rattus norvegicus (Rat) 457 cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; excitatory postsynaptic potential [GO:0060079]; lactation [GO:0007595]; nucleoside transport [GO:0015858]; sleep [GO:0030431]; uridine transport [GO:0015862] GO:0005337; GO:0005886; GO:0005887; GO:0007595; GO:0015858; GO:0015862; GO:0016323; GO:0016324; GO:0030431; GO:0060079; GO:0071333; GO:0071456; GO:0098794 0 0 0 PF01733; O60287 CHOYP_NPA1P.1.1 m.7492 sp NPA1P_HUMAN 34.588 425 257 6 43 460 23 433 1.73E-68 241 NPA1P_HUMAN reviewed Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) URB1 C21orf108 KIAA0539 NOP254 NPA1 Homo sapiens (Human) 2271 0 GO:0005730; GO:0044822 0 0 0 PF16201;PF11707; O70277 CHOYP_BRAFLDRAFT_241726.7.22 m.20485 sp TRIM3_RAT 28.333 120 82 3 52 168 625 743 1.73E-07 53.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_82426.17.20 m.58925 sp TRIM3_HUMAN 20.797 577 378 19 11 545 57 596 1.73E-10 67.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_88217.7.14 m.32441 sp TRIM3_HUMAN 23.264 288 184 11 288 552 469 742 1.73E-08 61.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_LOC100634336.3.4 m.53822 sp TRIM3_HUMAN 22.059 272 183 9 298 553 486 744 1.73E-07 57.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88572 CHOYP_LRP6.1.6 m.878 sp LRP6_MOUSE 32.453 265 169 4 26 288 327 583 1.73E-35 149 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; O88741 CHOYP_BRAFLDRAFT_57407.1.1 m.28838 sp GDAP1_MOUSE 31.111 315 198 7 27 328 26 334 1.73E-40 148 GDAP1_MOUSE reviewed Ganglioside-induced differentiation-associated protein 1 (GDAP1) Gdap1 Mus musculus (Mouse) 358 glutathione metabolic process [GO:0006749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; protein targeting to mitochondrion [GO:0006626]; response to retinoic acid [GO:0032526] GO:0000266; GO:0004364; GO:0005634; GO:0005737; GO:0005739; GO:0006626; GO:0006749; GO:0008053; GO:0016020; GO:0031307; GO:0032526 0 0 0 PF13417; P00491 CHOYP_LOC101162955.1.1 m.2845 sp PNPH_HUMAN 51.071 280 137 0 60 339 3 282 1.73E-103 308 PNPH_HUMAN reviewed Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Homo sapiens (Human) 289 immune response [GO:0006955]; inosine catabolic process [GO:0006148]; interleukin-2 secretion [GO:0070970]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of T cell proliferation [GO:0042102]; purine-containing compound salvage [GO:0043101]; purine nucleotide catabolic process [GO:0006195]; response to drug [GO:0042493]; urate biosynthetic process [GO:0034418] GO:0001882; GO:0002060; GO:0004731; GO:0005622; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0006139; GO:0006148; GO:0006195; GO:0006738; GO:0006955; GO:0008144; GO:0034356; GO:0034418; GO:0042102; GO:0042301; GO:0042493; GO:0043101; GO:0046638; GO:0070062; GO:0070970 PATHWAY: Purine metabolism; purine nucleoside salvage. 0 0 PF01048; P23800 CHOYP_LOC754700.1.2 m.19281 sp RCC1_MESAU 51.685 89 42 1 37 124 329 417 1.73E-21 91.3 RCC1_MESAU reviewed Regulator of chromosome condensation (Chromosome condensation protein 1) RCC1 CHC1 Mesocricetus auratus (Golden hamster) 421 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0005085; GO:0005634; GO:0005737; GO:0007059; GO:0007067; GO:0031492; GO:0051225; GO:0051301 0 0 0 PF00415; P24153 CHOYP_EMPA.1.1 m.31689 sp HAPT_VIBCH 28.016 257 166 10 76 322 69 316 1.73E-22 101 HAPT_VIBCH reviewed Hemagglutinin/proteinase (HA/protease) (EC 3.4.24.-) (Vibriolysin) hap VC_A0865 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 609 pathogenesis [GO:0009405]; proteolysis [GO:0006508] GO:0004222; GO:0005576; GO:0006508; GO:0009405; GO:0046872 0 0 0 PF07504;PF03413;PF01447;PF02868;PF04151; P24783 CHOYP_DBP2.1.2 m.39949 sp DBP2_YEAST 50.35 286 135 4 1 284 216 496 1.73E-87 277 DBP2_YEAST reviewed ATP-dependent RNA helicase DBP2 (EC 3.6.4.13) (DEAD box protein 2) (p68-like protein) DBP2 YNL112W N1945 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 546 "messenger ribonucleoprotein complex assembly [GO:1990120]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364]" GO:0000184; GO:0003723; GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006364; GO:0008186; GO:0010501; GO:0071042; GO:1990120 0 0 0 PF00270;PF00271; P37380 CHOYP_RL17.4.7 m.40031 sp RL17_PODCA 74.59 122 31 0 1 122 1 122 1.73E-64 197 RL17_PODCA reviewed 60S ribosomal protein L17 RPL17 Podocoryna carnea (Jellyfish) 183 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 cd00336; PF00237; P51989 CHOYP_ROA3.2.2 m.11068 sp RO21_XENLA 47.701 174 87 3 18 189 4 175 1.73E-44 165 RO21_XENLA reviewed Heterogeneous nuclear ribonucleoprotein A2 homolog 1 (hnRNP A2(A)) 0 Xenopus laevis (African clawed frog) 346 0 GO:0000166; GO:0003723; GO:0005634; GO:0030529 0 0 0 PF00076; P54802 CHOYP_NAGLU.1.2 m.26215 sp ANAG_HUMAN 32.258 93 61 1 6 98 493 583 1.73E-09 57 ANAG_HUMAN reviewed Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form] NAGLU UFHSD1 Homo sapiens (Human) 743 cerebellar Purkinje cell layer development [GO:0021680]; glycosaminoglycan catabolic process [GO:0006027]; inner ear receptor cell development [GO:0060119]; locomotor rhythm [GO:0045475]; lysosome organization [GO:0007040]; middle ear morphogenesis [GO:0042474]; nervous system development [GO:0007399]; retinal rod cell development [GO:0046548] GO:0004561; GO:0005764; GO:0006027; GO:0007040; GO:0007399; GO:0021680; GO:0042474; GO:0043202; GO:0045475; GO:0046548; GO:0060119; GO:0070062 0 0 0 PF05089;PF12972;PF12971; Q0GNC1 CHOYP_LOC100375422.1.1 m.62856 sp INF2_MOUSE 39.752 322 186 5 11 331 32 346 1.73E-67 234 INF2_MOUSE reviewed Inverted formin-2 Inf2 Mus musculus (Mouse) 1273 actin cytoskeleton organization [GO:0030036]; regulation of cellular component size [GO:0032535]; regulation of mitochondrial fission [GO:0090140] GO:0030036; GO:0032535; GO:0048471; GO:0090140 0 0 0 PF06367;PF06371;PF02181;PF02205; Q16527 CHOYP_MLP2.2.4 m.55445 sp CSRP2_HUMAN 45.876 194 96 3 214 403 4 192 1.73E-53 179 CSRP2_HUMAN reviewed Cysteine and glycine-rich protein 2 (Cysteine-rich protein 2) (CRP2) (LIM domain only protein 5) (LMO-5) (Smooth muscle cell LIM protein) (SmLIM) CSRP2 LMO5 SMLIM Homo sapiens (Human) 193 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; myoblast differentiation [GO:0045445] GO:0005634; GO:0005925; GO:0007275; GO:0008270; GO:0030154; GO:0045445 0 0 0 PF00412; Q55E58 CHOYP_BRAFLDRAFT_86694.2.3 m.40694 sp PATS1_DICDI 23.569 297 178 10 398 682 1764 2023 1.73E-12 75.9 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q55E58 CHOYP_TRIADDRAFT_57945.3.3 m.55640 sp PATS1_DICDI 31.275 761 415 22 2291 3006 1491 2188 1.73E-76 289 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5E9R0 CHOYP_BRAFLDRAFT_214404.1.1 m.19623 sp PRR5L_BOVIN 39.167 120 73 0 74 193 55 174 1.73E-26 106 PRR5L_BOVIN reviewed Proline-rich protein 5-like (Protein observed with Rictor-2) (Protor-2) PRR5L PROTOR2 Bos taurus (Bovine) 368 negative regulation of protein phosphorylation [GO:0001933]; negative regulation of signal transduction [GO:0009968]; regulation of fibroblast migration [GO:0010762]; TORC2 signaling [GO:0038203] GO:0001933; GO:0009968; GO:0010762; GO:0031932; GO:0038203 0 0 0 PF08539; Q5F371 CHOYP_LOC591290.1.3 m.18510 sp SBNO1_CHICK 45.131 421 222 4 83 500 253 667 1.73E-115 392 SBNO1_CHICK reviewed Protein strawberry notch homolog 1 SBNO1 RCJMB04_30k7 Gallus gallus (Chicken) 1239 "regulation of transcription, DNA-templated [GO:0006355]" GO:0006355 0 0 0 PF13871; Q5G267 CHOYP_TRIADDRAFT_53242.1.3 m.21872 sp NETR_MACMU 45.291 223 118 3 301 522 281 500 1.73E-54 201 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5R4H0 CHOYP_LOC100209242.1.1 m.17553 sp ZNT9_PONAB 32.321 461 288 9 124 568 117 569 1.73E-66 229 ZNT9_PONAB reviewed Zinc transporter 9 (ZnT-9) (Solute carrier family 30 member 9) SLC30A9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 569 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; zinc II ion transport [GO:0006829]" GO:0005634; GO:0006351; GO:0006355; GO:0006829; GO:0008324; GO:0016021 0 0 0 PF01545; Q5R7P7 CHOYP_LOC100538996.1.1 m.14935 sp TAF9B_PONAB 42.857 266 124 8 3 264 7 248 1.73E-63 202 TAF9B_PONAB reviewed Transcription initiation factor TFIID subunit 9B TAF9B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 251 "DNA-templated transcription, initiation [GO:0006352]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006352; GO:0006355 0 0 cd07979; PF02291; Q5R868 CHOYP_NEMVEDRAFT_V1G202318.1.1 m.18731 sp TM246_PONAB 30.581 327 207 10 15 335 69 381 1.73E-38 144 TM246_PONAB reviewed Transmembrane protein 246 TMEM246 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 403 0 GO:0016021 0 0 0 0 Q5ZJB4 CHOYP_IKKA.1.6 m.1640 sp IKKA_CHICK 50 416 204 2 2 413 90 505 1.73E-138 416 IKKA_CHICK reviewed Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) CHUK IKKA RCJMB04_19h23 Gallus gallus (Chicken) 759 cellular response to tumor necrosis factor [GO:0071356]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0008384; GO:0042803; GO:0045944; GO:0046982; GO:0071356 0 0 0 PF12179;PF00069; Q61704 CHOYP_LOC100917573.1.1 m.44457 sp ITIH3_MOUSE 40.503 358 191 6 36 384 44 388 1.73E-71 248 ITIH3_MOUSE reviewed Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) Itih3 Mus musculus (Mouse) 889 hyaluronan metabolic process [GO:0030212] GO:0004867; GO:0030212; GO:0070062 0 0 0 PF06668;PF08487;PF00092; Q6CPK7 CHOYP_BRAFLDRAFT_122983.1.1 m.46348 sp KAPR_KLULA 37.755 98 59 2 74 171 361 456 1.73E-09 63.5 KAPR_KLULA reviewed cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) PKAR KLLA0E04070g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) 466 negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of protein export from nucleus [GO:0046827]; protein localization to bud neck [GO:0097271] GO:0004862; GO:0005634; GO:0005829; GO:0005886; GO:0005952; GO:0008603; GO:0030552; GO:0045762; GO:0046580; GO:0046827; GO:0051447; GO:0097271 0 0 0 PF00027;PF02197; Q6PFY8 CHOYP_TRIM45.7.9 m.23708 sp TRI45_MOUSE 29.703 202 120 7 8 196 129 321 1.73E-12 70.9 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6Q899 CHOYP_BRAFLDRAFT_249506.1.2 m.2405 sp DDX58_MOUSE 36.298 697 399 18 937 1611 241 914 1.73E-107 369 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6V0K7 CHOYP_TRIADDRAFT_54271.1.1 m.21905 sp OIT3_RAT 27.907 172 115 4 18 180 1 172 1.73E-12 70.5 OIT3_RAT reviewed Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) 546 0 GO:0005509; GO:0005635 0 0 0 PF00100; Q6YHK3 CHOYP_BRAFLDRAFT_120995.1.1 m.57419 sp CD109_HUMAN 32.437 595 365 14 54 630 843 1418 1.73E-87 301 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q7TST9 CHOYP_TBX3.1.1 m.59254 sp TBX3_RAT 56.359 401 140 9 8 374 11 410 1.73E-135 417 TBX3_RAT reviewed T-box transcription factor TBX3 (T-box protein 3) Tbx3 Rattus norvegicus (Rat) 743 "anterior/posterior axis specification, embryo [GO:0008595]; atrioventricular bundle cell differentiation [GO:0003167]; blood vessel development [GO:0001568]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac muscle cell fate commitment [GO:0060923]; cell aging [GO:0007569]; cellular senescence [GO:0090398]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; limbic system development [GO:0021761]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mammary gland development [GO:0030879]; mammary placode formation [GO:0060596]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; outflow tract morphogenesis [GO:0003151]; palate development [GO:0060021]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription, DNA-templated [GO:0045893]; sinoatrial node cell development [GO:0060931]; skeletal system development [GO:0001501]; specification of organ position [GO:0010159]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]; ventricular septum morphogenesis [GO:0060412]" GO:0000122; GO:0000978; GO:0001078; GO:0001501; GO:0001568; GO:0001701; GO:0001947; GO:0003151; GO:0003167; GO:0005634; GO:0006351; GO:0007569; GO:0008284; GO:0008595; GO:0010159; GO:0019827; GO:0021761; GO:0030539; GO:0030540; GO:0030857; GO:0030879; GO:0032275; GO:0035115; GO:0035116; GO:0042733; GO:0043066; GO:0043565; GO:0045662; GO:0045787; GO:0045892; GO:0045893; GO:0046884; GO:0048332; GO:0060021; GO:0060412; GO:0060444; GO:0060596; GO:0060923; GO:0060931; GO:0090398; GO:2000648 0 0 0 PF00907;PF12598; Q8HXX6 CHOYP_BRAFLDRAFT_124972.1.5 m.3844 sp SAP3_MACFA 30.769 182 113 7 1 174 10 186 1.73E-23 95.1 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8N7A1 CHOYP_LOC101242114.1.1 m.13149 sp KLDC1_HUMAN 29.745 353 213 15 32 368 13 346 1.73E-36 139 KLDC1_HUMAN reviewed Kelch domain-containing protein 1 KLHDC1 MSTP025 Homo sapiens (Human) 406 0 GO:0005737 0 0 0 0 Q8NHV1 CHOYP_GIMA4.6.7 m.56041 sp GIMA7_HUMAN 43.694 222 122 2 106 326 9 228 1.73E-60 204 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8W257 CHOYP_LOC100208937.1.4 m.6836 sp PFI_PTIFI 23.462 260 164 5 56 287 26 278 1.73E-13 76.3 PFI_PTIFI reviewed Polyenoic fatty acid isomerase (PFI) (EC 5.3.3.13) 0 Ptilota filicina (Red alga) 500 0 GO:0016491; GO:0034016 0 0 0 PF01593; Q8WWF8 CHOYP_LOC100180354.1.1 m.44438 sp CAPSL_HUMAN 49.738 191 93 2 9 198 20 208 1.73E-57 183 CAPSL_HUMAN reviewed Calcyphosin-like protein CAPSL Homo sapiens (Human) 208 0 GO:0005509; GO:0005737 0 0 0 PF13499; Q91755 CHOYP_GRID1.1.1 m.6365 sp GRIK2_XENLA 32.524 206 127 3 1 203 20 216 1.73E-31 119 GRIK2_XENLA reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6) (Fragment)" grik2 glur6 Xenopus laevis (African clawed frog) 285 0 GO:0004970; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF00060; Q91WV7 CHOYP_BRAFLDRAFT_265208.5.7 m.49178 sp SLC31_MOUSE 37.853 177 71 4 5 180 103 241 1.73E-30 120 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q95R48 CHOYP_DWIL_GK11734.1.1 m.16781 sp OCTL_DROME 34.659 528 299 8 4 494 3 521 1.73E-95 303 OCTL_DROME reviewed Organic cation transporter-like protein Orct2 CG13610 Drosophila melanogaster (Fruit fly) 567 germ-band shortening [GO:0007390]; organic cation transport [GO:0015695]; positive regulation of cell growth [GO:0030307]; positive regulation of multicellular organism growth [GO:0040018] GO:0005887; GO:0007390; GO:0015101; GO:0015695; GO:0022891; GO:0030307; GO:0040018 0 0 cd06174; PF00083; Q96RW7 CHOYP_DSCAM.3.3 m.65848 sp HMCN1_HUMAN 23.102 619 386 27 48 604 2561 3151 1.73E-16 89 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99946 CHOYP_LOC100379067.4.4 m.64828 sp PRRT1_HUMAN 36.486 74 47 0 29 102 219 292 1.73E-10 59.3 PRRT1_HUMAN reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) PRRT1 C6orf31 NG5 Homo sapiens (Human) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q99LJ0 CHOYP_CTTB2.1.2 m.1599 sp CT2NL_MOUSE 45.52 279 146 3 35 313 6 278 1.73E-65 228 CT2NL_MOUSE reviewed CTTNBP2 N-terminal-like protein Cttnbp2nl Kiaa1433 Mus musculus (Mouse) 638 negative regulation of transmembrane transport [GO:0034763]; negative regulation of transporter activity [GO:0032410]; protein dephosphorylation [GO:0006470] GO:0005737; GO:0006470; GO:0015629; GO:0032410; GO:0034763; GO:0051721 0 0 0 PF09727; Q9D9G2 CHOYP_PEBP4.1.1 m.44187 sp PEBP4_MOUSE 41.096 146 77 6 86 228 82 221 1.73E-22 94.7 PEBP4_MOUSE reviewed Phosphatidylethanolamine-binding protein 4 (PEBP-4) Pebp4 Mus musculus (Mouse) 242 0 GO:0005764; GO:0070062 0 0 0 PF01161; Q9ESN6 CHOYP_BRAFLDRAFT_79377.14.30 m.33087 sp TRIM2_MOUSE 28.804 184 117 6 205 384 534 707 1.73E-11 69.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9FT69 CHOYP_contig_021543 m.24755 sp RQSIM_ARATH 37.956 137 72 4 1 134 141 267 1.73E-10 63.9 RQSIM_ARATH reviewed ATP-dependent DNA helicase Q-like SIM (EC 3.6.4.12) (RecQ-like protein SIM) (AtRecQsim) (Similar to RecQ protein) RECQSIM At5g27680 T1G16.10 Arabidopsis thaliana (Mouse-ear cress) 858 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0003677; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006281; GO:0009378; GO:0043138; GO:0043140; GO:0046872 0 0 0 PF00270;PF00271;PF16124; Q9JLC8 CHOYP_SACS.6.17 m.35149 sp SACS_MOUSE 23.62 453 309 16 453 875 923 1368 1.73E-15 85.5 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9UGM3 CHOYP_LOC580940.2.2 m.13175 sp DMBT1_HUMAN 42.713 494 209 9 6 429 573 1062 1.73E-99 329 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9VZW5 CHOYP_FR.1.2 m.1682 sp FMAR_DROME 32.033 359 222 6 26 375 98 443 1.73E-52 186 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; Q9VZW5 CHOYP_PHUM_PHUM268560.1.2 m.42366 sp FMAR_DROME 26.935 323 198 16 11 309 99 407 1.73E-18 89.7 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; A2VDD2 CHOYP_BRAFLDRAFT_126378.2.2 m.11826 sp TC1DB_XENLA 34.532 139 88 2 90 228 41 176 1.74E-25 100 TC1DB_XENLA reviewed Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) 176 0 0 0 0 0 PF03645; H3BPM6 CHOYP_LOC755844.1.1 m.17448 sp MKROS_HUMAN 33.333 213 128 5 4 211 5 208 1.74E-38 135 MKROS_HUMAN reviewed MKRN2 opposite strand protein (MKRN2 antisense RNA 1) (MKRN2 antisense gene protein 1) MKRN2OS C3orf83 MKRN2-AS1 Homo sapiens (Human) 223 0 0 0 0 0 PF16044; O02722 CHOYP_contig_050283 m.59807 sp TIMP1_HORSE 36.735 98 48 4 5 101 10 94 1.74E-06 47.8 TIMP1_HORSE reviewed Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Equus caballus (Horse) 207 negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; positive regulation of cell proliferation [GO:0008284]; regulation of integrin-mediated signaling pathway [GO:2001044]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] GO:0002020; GO:0005125; GO:0005578; GO:0005615; GO:0008191; GO:0008284; GO:0009725; GO:0010951; GO:0034097; GO:0043086; GO:0046872; GO:0051045; GO:2001044 0 0 0 PF00965; O18404 CHOYP_LOC732961.1.1 m.29082 sp HCD2_DROME 38.846 260 144 6 33 287 2 251 1.74E-54 180 HCD2_DROME reviewed 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH) scu CG7113 Drosophila melanogaster (Fruit fly) 255 acyl-CoA metabolic process [GO:0006637]; androgen metabolic process [GO:0008209]; ecdysone metabolic process [GO:0008205]; estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; steroid metabolic process [GO:0008202]; tRNA processing [GO:0008033] GO:0003857; GO:0004303; GO:0005739; GO:0005811; GO:0005829; GO:0005875; GO:0006631; GO:0006637; GO:0008033; GO:0008202; GO:0008205; GO:0008209; GO:0008210; GO:0016229; GO:0018454; GO:0030283; GO:0047015; GO:0047022; GO:0047035 0 0 0 PF00106; O46160 CHOYP_RL14.3.9 m.23022 sp RL14_LUMRU 61.053 95 36 1 1 94 50 144 1.74E-31 110 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O70511 CHOYP_LOC100369925.1.2 m.36252 sp ANK3_RAT 34.466 206 129 1 13 218 624 823 1.74E-29 119 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O75179 CHOYP_LOC762964.3.10 m.23560 sp ANR17_HUMAN 34 550 332 16 8 541 155 689 1.74E-63 229 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75376 CHOYP_LOC588549.2.2 m.24056 sp NCOR1_HUMAN 54.054 370 156 5 184 540 142 510 1.74E-104 379 NCOR1_HUMAN reviewed Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) NCOR1 KIAA1047 Homo sapiens (Human) 2440 cellular lipid metabolic process [GO:0044255]; cerebellum development [GO:0021549]; circadian rhythm [GO:0007623]; covalent chromatin modification [GO:0016569]; lactation [GO:0007595]; negative regulation of JNK cascade [GO:0046329]; negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cell proliferation [GO:0008284]; regulation of fatty acid transport [GO:2000191]; regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [GO:0072362]; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [GO:0072368]; skeletal muscle tissue development [GO:0007519]; spindle assembly [GO:0051225]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0000790; GO:0001012; GO:0001102; GO:0003682; GO:0003714; GO:0005634; GO:0005654; GO:0005876; GO:0006366; GO:0007519; GO:0007595; GO:0007623; GO:0008284; GO:0016020; GO:0016569; GO:0016922; GO:0017053; GO:0021549; GO:0035257; GO:0042826; GO:0044212; GO:0044255; GO:0046329; GO:0046966; GO:0048471; GO:0051225; GO:0072362; GO:0072368; GO:1903799; GO:2000191 0 0 0 PF15784;PF00249; P02362 CHOYP_RS7.1.9 m.4921 sp RS7_XENLA 68.041 194 60 2 22 213 1 194 1.74E-86 256 RS7_XENLA reviewed 40S ribosomal protein S7 (40S ribosomal protein S8) rps7 rps8 Xenopus laevis (African clawed frog) 194 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01251; P0C6B8 CHOYP_LOC100367084.10.22 m.44502 sp SVEP1_RAT 24.093 689 412 22 111 707 436 1105 1.74E-30 135 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P10394 CHOYP_CRE_22626.1.1 m.31600 sp POL4_DROME 26.926 1259 774 30 14 1202 55 1237 1.74E-134 448 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P17900 CHOYP_LOC100029456.1.1 m.2832 sp SAP3_HUMAN 26.573 143 100 3 262 400 50 191 1.74E-15 77.8 SAP3_HUMAN reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short] GM2A Homo sapiens (Human) 193 ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; positive regulation of hydrolase activity [GO:0051345] GO:0005319; GO:0005739; GO:0005889; GO:0006687; GO:0006689; GO:0007611; GO:0009313; GO:0009898; GO:0016004; GO:0019915; GO:0030290; GO:0032428; GO:0043202; GO:0045179; GO:0050885; GO:0051345; GO:0070062 0 0 0 PF02221; P18433 CHOYP_PTPRA.11.22 m.47624 sp PTPRA_HUMAN 30.277 687 436 21 102 764 133 800 1.74E-81 280 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P29691 CHOYP_EEF2.1.2 m.44028 sp EF2_CAEEL 78.947 152 23 1 1 143 1 152 1.74E-75 243 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P55162 CHOYP_NCKP1.4.4 m.53213 sp HEM_DROME 46.875 128 50 3 1 128 884 993 1.74E-29 115 HEM_DROME reviewed Membrane-associated protein Hem (dHem-2) Hem HEM2 CG5837 Drosophila melanogaster (Fruit fly) 1126 actin cytoskeleton organization [GO:0030036]; axonogenesis [GO:0007409]; cell adhesion mediated by integrin [GO:0033627]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; central nervous system development [GO:0007417]; chaeta morphogenesis [GO:0008407]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; myoblast fusion [GO:0007520]; neuromuscular junction development [GO:0007528]; neuron migration [GO:0001764]; phagocytosis [GO:0006909]; regulation of cell shape [GO:0008360] GO:0000902; GO:0001764; GO:0005886; GO:0006909; GO:0007010; GO:0007409; GO:0007417; GO:0007520; GO:0007528; GO:0008360; GO:0008407; GO:0016021; GO:0030031; GO:0030036; GO:0030866; GO:0031209; GO:0033627 0 0 0 PF09735; P82596 CHOYP_PLC.5.5 m.35927 sp PLC_HALLA 36.09 133 79 3 109 240 2 129 1.74E-22 92.8 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; P97864 CHOYP_CASP7.21.23 m.63852 sp CASP7_MOUSE 46.377 138 63 4 1 131 154 287 1.74E-31 116 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q0IH24 CHOYP_LOC100492226.1.2 m.9196 sp SPEF1_XENLA 39.286 252 119 6 18 268 1 219 1.74E-43 151 SPEF1_XENLA reviewed Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) 229 0 GO:0005737; GO:0005930 0 0 0 PF06294; Q0V8E7 CHOYP_BRAFLDRAFT_64338.2.2 m.52295 sp STRA6_BOVIN 24.837 306 216 4 347 638 362 667 1.74E-28 124 STRA6_BOVIN reviewed Stimulated by retinoic acid gene 6 protein homolog STRA6 Bos taurus (Bovine) 668 0 GO:0004872; GO:0005886; GO:0016021; GO:0051183 0 0 0 0 Q12542 CHOYP_LOC100206475.12.16 m.52682 sp LAC2_AGABI 31.481 594 253 22 72 638 22 488 1.74E-58 209 LAC2_AGABI reviewed Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Laccase II) (Urishiol oxidase 2) lcc2 Agaricus bisporus (White button mushroom) 520 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q28F51 CHOYP_BRAFLDRAFT_223429.2.2 m.38659 sp TADBP_XENTR 57.394 284 100 2 26 309 1 263 1.74E-114 345 TADBP_XENTR reviewed TAR DNA-binding protein 43 (TDP-43) tardbp tdp43 TGas087d21.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 409 "mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355; GO:0006397; GO:0008380 0 0 0 PF00076; Q3SZZ2 CHOYP_HS12A.25.33 m.60353 sp XBP1_BOVIN 37.5 248 123 6 5 220 14 261 1.74E-35 129 XBP1_BOVIN reviewed "X-box-binding protein 1 (XBP-1) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" XBP1 Bos taurus (Bovine) 261 adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein destabilization [GO:0031648]; regulation of autophagy [GO:0010506]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription from RNA polymerase II promoter [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000122; GO:0000977; GO:0000981; GO:0001047; GO:0001158; GO:0001525; GO:0001889; GO:0001934; GO:0001935; GO:0002639; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006366; GO:0006511; GO:0006990; GO:0007517; GO:0010506; GO:0010508; GO:0010832; GO:0014065; GO:0016049; GO:0030176; GO:0031017; GO:0031062; GO:0031490; GO:0031648; GO:0031670; GO:0032008; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035924; GO:0042149; GO:0042632; GO:0042993; GO:0043066; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051024; GO:0055089; GO:0055092; GO:0060612; GO:0060691; GO:0070059; GO:0071222; GO:0071230; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:1900100; GO:1900102; GO:1900103; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1990418; GO:2000347; GO:2000353; GO:2000778 0 0 0 PF07716; Q3SZZ2 CHOYP_XBP1.1.4 m.28929 sp XBP1_BOVIN 37.5 248 123 6 5 220 14 261 1.74E-35 129 XBP1_BOVIN reviewed "X-box-binding protein 1 (XBP-1) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" XBP1 Bos taurus (Bovine) 261 adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein destabilization [GO:0031648]; regulation of autophagy [GO:0010506]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription from RNA polymerase II promoter [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000122; GO:0000977; GO:0000981; GO:0001047; GO:0001158; GO:0001525; GO:0001889; GO:0001934; GO:0001935; GO:0002639; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006366; GO:0006511; GO:0006990; GO:0007517; GO:0010506; GO:0010508; GO:0010832; GO:0014065; GO:0016049; GO:0030176; GO:0031017; GO:0031062; GO:0031490; GO:0031648; GO:0031670; GO:0032008; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035924; GO:0042149; GO:0042632; GO:0042993; GO:0043066; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051024; GO:0055089; GO:0055092; GO:0060612; GO:0060691; GO:0070059; GO:0071222; GO:0071230; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:1900100; GO:1900102; GO:1900103; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1990418; GO:2000347; GO:2000353; GO:2000778 0 0 0 PF07716; Q49LS8 CHOYP_XKR7.1.2 m.30991 sp XKR6_TETNG 28.013 307 202 4 13 318 87 375 1.74E-26 112 XKR6_TETNG reviewed XK-related protein 6 xkr6 xrg6 GSTENG00030285001 GSTENG00030286001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 578 0 GO:0016021 0 0 0 PF09815; Q4U4S6 CHOYP_LOC100746973.1.2 m.1565 sp XIRP2_MOUSE 43.836 73 31 2 779 843 3287 3357 1.74E-08 62.4 XIRP2_MOUSE reviewed Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Myogenic MEF2-activated Xin-related protein) (Myomaxin) (mXinbeta) Xirp2 Cmya3 Xin2 Mus musculus (Mouse) 3784 actin cytoskeleton organization [GO:0030036]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; ventricular septum development [GO:0003281] GO:0003281; GO:0008270; GO:0030018; GO:0030036; GO:0030054; GO:0045216; GO:0051393; GO:0055008 0 0 0 PF00412;PF08043; Q58D15 CHOYP_TRI54.1.1 m.45425 sp TRI54_BOVIN 28.571 287 166 12 1 269 20 285 1.74E-23 105 TRI54_BOVIN reviewed Tripartite motif-containing protein 54 TRIM54 Bos taurus (Bovine) 366 multicellular organism development [GO:0007275]; muscle cell development [GO:0055001]; negative regulation of microtubule depolymerization [GO:0007026] GO:0005874; GO:0005875; GO:0007026; GO:0007275; GO:0008270; GO:0030018; GO:0055001 0 0 0 PF00643;PF13445; Q5EAD5 CHOYP_LOC100378658.1.1 m.38454 sp PGTB1_BOVIN 60.345 348 128 3 4 346 16 358 1.74E-157 450 PGTB1_BOVIN reviewed Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta) PGGT1B Bos taurus (Bovine) 377 protein geranylgeranylation [GO:0018344] GO:0004661; GO:0004662; GO:0005953; GO:0008270; GO:0018344 0 0 0 PF00432; Q5PPV2 CHOYP_BRAFLDRAFT_117858.3.3 m.61651 sp TEKT4_XENLA 52.083 432 195 3 1 429 1 423 1.74E-149 434 TEKT4_XENLA reviewed Tektin-4 tekt4 Xenopus laevis (African clawed frog) 446 0 GO:0005737; GO:0005874; GO:0005929 0 0 0 0 Q5TYV4 CHOYP_VIPAR.1.1 m.38528 sp SPE39_DANRE 43.732 343 185 3 206 548 149 483 1.74E-92 294 SPE39_DANRE reviewed Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) vipas39 spe39 vipar si:ch211-20b12.1 Danio rerio (Zebrafish) (Brachydanio rerio) 483 "cell differentiation [GO:0030154]; hepaticobiliary system development [GO:0061008]; intracellular protein transport [GO:0006886]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0005769; GO:0005770; GO:0006351; GO:0006355; GO:0006886; GO:0007283; GO:0016023; GO:0030154; GO:0055037; GO:0061008 0 0 0 PF04840; Q6DHJ1 CHOYP_TYW3.1.1 m.25851 sp TYW3_DANRE 45.418 251 131 4 2 252 4 248 1.74E-67 213 TYW3_DANRE reviewed tRNA wybutosine-synthesizing protein 3 homolog (tRNA-yW-synthesizing protein 3) (EC 2.1.1.282) (tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase) tyw3 si:ch211-215b16.3 zgc:92277 Danio rerio (Zebrafish) (Brachydanio rerio) 251 tRNA processing [GO:0008033] GO:0008033; GO:0008168 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 PF02676; Q6UX65 CHOYP_ISCW_ISCW009192.1.1 m.29729 sp DRAM2_HUMAN 38.926 149 85 3 40 188 3 145 1.74E-24 99.4 DRAM2_HUMAN reviewed DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) DRAM2 TMEM77 PSEC0031 UNQ154/PRO180 Homo sapiens (Human) 266 apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601] GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006914; GO:0006915; GO:0007601; GO:0010506; GO:0016021; GO:0016324; GO:0043231; GO:0045494 0 0 0 PF10277; Q7ZWG6 CHOYP_LOC101077655.1.1 m.35117 sp PCFT_DANRE 26.009 446 296 12 68 509 57 472 1.74E-44 166 PCFT_DANRE reviewed Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) 481 transmembrane transport [GO:0055085] GO:0005542; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q7ZXX1 CHOYP_CADM3.1.4 m.23537 sp CADM3_XENLA 26.101 318 194 12 90 406 69 346 1.74E-15 80.9 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q801S4 CHOYP_PHUM_PHUM615920.1.1 m.51353 sp K0930_XENLA 40.849 377 177 9 16 370 47 399 1.74E-82 259 K0930_XENLA reviewed Uncharacterized protein KIAA0930 homolog 0 Xenopus laevis (African clawed frog) 399 0 0 0 0 0 PF09741; Q8BYU6 CHOYP_LOC100185473.1.1 m.5316 sp TOIP2_MOUSE 22.118 321 188 14 78 378 206 484 1.74E-06 53.5 TOIP2_MOUSE reviewed Torsin-1A-interacting protein 2 Tor1aip2 Ifrg15 Lull1 Mus musculus (Mouse) 502 endoplasmic reticulum organization [GO:0007029]; positive regulation of ATPase activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435] GO:0001671; GO:0005635; GO:0005783; GO:0005789; GO:0007029; GO:0016021; GO:0032781; GO:0051117; GO:0090435 0 0 0 PF05609; Q8IT98 CHOYP_RS18.1.11 m.11538 sp RS18_ARGIR 91.27 126 11 0 1 126 27 152 1.74E-84 246 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8IUH5 CHOYP_ZDH17.1.1 m.66174 sp ZDH17_HUMAN 56.846 241 104 0 42 282 54 294 1.74E-96 299 ZDH17_HUMAN reviewed Palmitoyltransferase ZDHHC17 (EC 2.3.1.225) (Huntingtin yeast partner H) (Huntingtin-interacting protein 14) (HIP-14) (Huntingtin-interacting protein 3) (HIP-3) (Huntingtin-interacting protein H) (Putative MAPK-activating protein PM11) (Putative NF-kappa-B-activating protein 205) (Zinc finger DHHC domain-containing protein 17) (DHHC-17) ZDHHC17 HIP14 HIP3 HYPH KIAA0946 HSPC294 Homo sapiens (Human) 632 lipoprotein transport [GO:0042953]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein palmitoylation [GO:0018345] GO:0000139; GO:0004871; GO:0005737; GO:0005794; GO:0008270; GO:0015095; GO:0016021; GO:0016409; GO:0018345; GO:0019706; GO:0030054; GO:0030659; GO:0030660; GO:0042734; GO:0042802; GO:0042953; GO:0043123; GO:0043231 0 0 0 PF12796;PF01529; Q8K0U4 CHOYP_LOC100207121.8.9 m.60345 sp HS12A_MOUSE 33.333 630 355 11 4 574 51 674 1.74E-110 348 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q91VB4 CHOYP_BRAFLDRAFT_120515.1.1 m.62039 sp HPS3_MOUSE 23.731 788 470 25 301 1031 286 999 1.74E-42 172 HPS3_MOUSE reviewed Hermansky-Pudlak syndrome 3 protein homolog (Cocoa protein) Hps3 Coa Mus musculus (Mouse) 1002 organelle organization [GO:0006996]; pigmentation [GO:0043473] GO:0005737; GO:0006996; GO:0031084; GO:0043473 0 0 0 PF14763;PF14762;PF14761; Q91WE2 CHOYP_F192A.1.1 m.455 sp F192A_MOUSE 50 206 94 4 9 206 14 218 1.74E-45 155 F192A_MOUSE reviewed Protein FAM192A (NEFA-interacting nuclear protein NIP30) Fam192a Nip30 Mus musculus (Mouse) 254 0 GO:0005634 0 0 0 PF10187; Q96IZ5 CHOYP_LOC100083572.1.1 m.16113 sp RBM41_HUMAN 32.637 383 235 6 19 390 16 386 1.74E-53 186 RBM41_HUMAN reviewed RNA-binding protein 41 (RNA-binding motif protein 41) RBM41 Homo sapiens (Human) 413 "developmental process [GO:0032502]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0005689; GO:0030626; GO:0032502; GO:0097157 0 0 0 PF00076; Q96RW7 CHOYP_BRAFLDRAFT_85664.6.10 m.30553 sp HMCN1_HUMAN 48.472 229 118 0 454 682 4528 4756 1.74E-65 241 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q98SH3 CHOYP_AT1A.1.1 m.18018 sp ADRM1_CHICK 68.208 173 45 5 13 179 4 172 1.74E-72 230 ADRM1_CHICK reviewed Proteasomal ubiquitin receptor ADRM1 (Adhesion-regulating molecule 1) (ARM-1) ADRM1 Gallus gallus (Chicken) 406 proteasome assembly [GO:0043248] GO:0000502; GO:0005634; GO:0005737; GO:0043248; GO:0061133 0 0 0 PF04683;PF16550; Q99M80 CHOYP_PTPRE.5.19 m.26184 sp PTPRT_MOUSE 29.555 741 469 15 391 1096 731 1453 1.74E-84 304 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_87323.2.2 m.32569 sp TRIM2_MOUSE 25 200 142 6 134 327 547 744 1.74E-09 62.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JLB4 CHOYP_contig_030074 m.34185 sp CUBN_MOUSE 32.432 111 70 3 39 146 1396 1504 1.74E-09 63.9 CUBN_MOUSE reviewed Cubilin (Intrinsic factor-cobalamin receptor) Cubn Ifcr Mus musculus (Mouse) 3623 cholesterol metabolic process [GO:0008203]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0005509; GO:0005737; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005903; GO:0005905; GO:0006898; GO:0008203; GO:0015031; GO:0016324; GO:0030139; GO:0031419; GO:0042803; GO:0042953; GO:0045177; GO:0070062 0 0 0 PF00431;PF00008;PF12947;PF07645;PF12661; Q9PU85 CHOYP_ZGC_153997.1.2 m.21114 sp PIM3_COTJA 66.524 233 77 1 1 232 64 296 1.74E-113 332 PIM3_COTJA reviewed Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (qpim) PIM3 PIM-3 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 323 negative regulation of apoptotic process [GO:0043066] GO:0004674; GO:0005524; GO:0005737; GO:0043066 0 0 0 PF00069; Q9R050 CHOYP_LOC662190.1.3 m.1532 sp SSBP3_RAT 62.835 261 63 10 10 262 1 235 1.74E-77 248 SSBP3_RAT reviewed Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein) Ssbp3 Ssdp Ssdp1 Ssdp3 Rattus norvegicus (Rat) 361 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003697; GO:0005634; GO:0006351; GO:0006355 0 0 0 0 Q9UM22 CHOYP_BRAFLDRAFT_129110.2.2 m.65401 sp EPDR1_HUMAN 25.926 162 109 5 6 161 19 175 1.74E-11 64.3 EPDR1_HUMAN reviewed Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; Q9UQ07 CHOYP_BRAFLDRAFT_277962.1.1 m.5726 sp MOK_HUMAN 61.111 126 49 0 1 126 170 295 1.74E-50 181 MOK_HUMAN reviewed MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) MOK RAGE RAGE1 Homo sapiens (Human) 419 protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005929; GO:0006468; GO:0007165; GO:0097546 0 0 0 PF00069; Q9VUI3 CHOYP_EMAL.1.1 m.34889 sp EMAL_DROME 33.299 967 548 29 391 1320 169 1075 1.74E-149 483 EMAL_DROME reviewed Echinoderm microtubule-associated protein-like CG42247 DCX-EMAP CG42247 Drosophila melanogaster (Fruit fly) 1076 adult locomotory behavior [GO:0008344]; intracellular signal transduction [GO:0035556]; melanotic encapsulation of foreign target [GO:0035011]; sensory perception of sound [GO:0007605] GO:0005737; GO:0005874; GO:0007605; GO:0008017; GO:0008344; GO:0035011; GO:0035556; GO:0071683 0 0 cd01617; PF03607;PF03451;PF00400; A4QNG3 CHOYP_LOC100863610.1.1 m.24690 sp SOX14_XENTR 46.269 67 34 2 546 611 5 70 1.75E-08 58.9 SOX14_XENTR reviewed Transcription factor Sox-14 (SRY (sex determining region Y)-box 14) sox14 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 239 "hypothalamus development [GO:0021854]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0006351; GO:0007399; GO:0021854; GO:0043565; GO:0045892 0 0 0 PF00505;PF12336; A7MBJ4 CHOYP_LAR.2.2 m.57785 sp PTPRF_BOVIN 28.099 121 83 1 10 126 287 407 1.75E-10 60.5 PTPRF_BOVIN reviewed Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) PTPRF Bos taurus (Bovine) 1898 cell adhesion [GO:0007155]; cell migration [GO:0016477]; negative regulation of receptor binding [GO:1900121]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679] GO:0004725; GO:0007155; GO:0008201; GO:0016021; GO:0016477; GO:0031102; GO:0035335; GO:0035373; GO:0043005; GO:0043025; GO:0048679; GO:0070062; GO:1900121 0 0 0 PF00041;PF07679;PF00102; B3EWY9 CHOYP_contig_017941 m.21005 sp MLP_ACRMI 27.887 1065 614 41 136 1134 387 1363 1.75E-90 331 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O15259 CHOYP_LOC100890342.1.1 m.10194 sp NPHP1_HUMAN 37.755 98 59 1 118 215 162 257 1.75E-11 67 NPHP1_HUMAN reviewed Nephrocystin-1 (Juvenile nephronophthisis 1 protein) NPHP1 NPH1 Homo sapiens (Human) 732 actin cytoskeleton organization [GO:0030036]; cell projection organization [GO:0030030]; excretion [GO:0007588]; positive regulation of bicellular tight junction assembly [GO:1903348]; retina development in camera-type eye [GO:0060041]; signal transduction [GO:0007165]; single organismal cell-cell adhesion [GO:0016337]; spermatid differentiation [GO:0048515]; visual behavior [GO:0007632] GO:0005198; GO:0005829; GO:0005856; GO:0005911; GO:0005912; GO:0005923; GO:0007165; GO:0007588; GO:0007632; GO:0016020; GO:0016337; GO:0030030; GO:0030036; GO:0031514; GO:0032391; GO:0048515; GO:0060041; GO:1903348 0 0 0 PF00018; O35462 CHOYP_ANGP2.3.5 m.53111 sp ANGP2_RAT 41.406 128 68 3 233 359 283 404 1.75E-27 116 ANGP2_RAT reviewed Angiopoietin-2 (ANG-2) Angpt2 Agpt2 Rattus norvegicus (Rat) 496 angiogenesis [GO:0001525]; cellular response to growth factor stimulus [GO:0071363]; germ cell development [GO:0007281]; glomerulus vasculature development [GO:0072012]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of positive chemotaxis [GO:0050928]; organ regeneration [GO:0031100]; positive regulation of angiogenesis [GO:0045766]; response to activity [GO:0014823]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to radiation [GO:0009314]; Tie signaling pathway [GO:0048014] GO:0001525; GO:0001666; GO:0005615; GO:0005634; GO:0005886; GO:0007281; GO:0009314; GO:0009612; GO:0009749; GO:0010812; GO:0014070; GO:0014823; GO:0016525; GO:0031100; GO:0042995; GO:0043537; GO:0045766; GO:0046872; GO:0048014; GO:0050928; GO:0060135; GO:0071363; GO:0072012 0 0 0 PF00147; O54689 CHOYP_contig_051396 m.61416 sp CCR6_MOUSE 22.817 355 215 12 27 366 53 363 1.75E-09 62.8 CCR6_MOUSE reviewed C-C chemokine receptor type 6 (C-C CKR-6) (CC-CKR-6) (CCR-6) (KY411) (CD antigen CD196) Ccr6 Cmkbr6 Mus musculus (Mouse) 367 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; DN2 thymocyte differentiation [GO:1904155]; DN3 thymocyte differentiation [GO:1904156]; isotype switching to IgA isotypes [GO:0048290]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte migration [GO:0072676]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of sperm motility involved in capacitation [GO:0060474]; regulation of T cell migration [GO:2000404]; T cell migration [GO:0072678]; thymocyte migration [GO:0072679] GO:0002523; GO:0005829; GO:0006935; GO:0007204; GO:0009986; GO:0010634; GO:0016021; GO:0016493; GO:0019722; GO:0019957; GO:0036126; GO:0048290; GO:0060326; GO:0060474; GO:0072676; GO:0072678; GO:0072679; GO:0097228; GO:0097524; GO:1904155; GO:1904156; GO:2000404; GO:2000510 0 0 0 PF00001; P0C1H5 CHOYP_H2B.1.2 m.49738 sp H2B7_CHICK 87.069 116 13 1 33 148 13 126 1.75E-68 206 H2B7_CHICK reviewed Histone H2B 7 (H2B VII) H2B-VII Gallus gallus (Chicken) 126 nucleosome assembly [GO:0006334] GO:0000788; GO:0003677; GO:0005811; GO:0006334 0 0 0 PF00125; P0C8Q4 CHOYP_LOC100184557.2.2 m.25609 sp Y4990_ARATH 30.709 127 74 5 250 365 429 552 1.75E-06 53.9 Y4990_ARATH reviewed Uncharacterized protein At4g19900 At4g19900 F18F4.6 Arabidopsis thaliana (Mouse-ear cress) 644 0 0 0 0 0 PF04572;PF04488; P12890 CHOYP_AMD.1.1 m.37735 sp AMDB_XENLA 37.418 457 235 15 201 619 405 848 1.75E-82 281 AMDB_XENLA reviewed Peptidyl-glycine alpha-amidating monooxygenase B (PAM-B) (Peptide C-terminal alpha-amidating enzyme II) (AE-II) (Peptidyl-glycine alpha-amidating monooxygenase II) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase B (PHM-B) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase B (EC 4.3.2.5) (Peptidylamidoglycolate lyase-B) (PAL-B)] pam-b Xenopus laevis (African clawed frog) 875 peptide metabolic process [GO:0006518] GO:0004504; GO:0004598; GO:0005507; GO:0006518; GO:0016021; GO:0030658 0 0 0 PF03712;PF01082;PF01436; P15989 CHOYP_CO6A3.1.5 m.22134 sp CO6A3_CHICK 21.948 893 598 31 344 1166 13 876 1.75E-35 152 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P18127 CHOYP_LOC100493254.1.1 m.61124 sp ICEN_XANCT 34.495 545 317 7 1 505 308 852 1.75E-28 129 ICEN_XANCT reviewed Ice nucleation protein inaX Xanthomonas campestris pv. translucens 1567 0 GO:0009279; GO:0050825 0 0 0 PF00818; P18503 CHOYP_BRAFLDRAFT_76550.4.21 m.38730 sp CAS4_EPHMU 34.783 138 65 6 32 165 209 325 1.75E-07 53.9 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P21783 CHOYP_LOC100648516.1.1 m.64902 sp NOTC1_XENLA 31.526 701 376 31 1675 2313 718 1376 1.75E-61 239 NOTC1_XENLA reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (xOTCH) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 xotch Xenopus laevis (African clawed frog) 2524 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001525; GO:0004872; GO:0005509; GO:0005654; GO:0005886; GO:0006351; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P28828 CHOYP_PTPRT.44.45 m.62538 sp PTPRM_MOUSE 42.238 277 152 3 493 764 880 1153 1.75E-58 219 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P29691 CHOYP_EEF2.1.2 m.44027 sp EF2_CAEEL 89.933 149 15 0 1 149 419 567 1.75E-92 289 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P31255 CHOYP_UBA1.1.2 m.5753 sp UBE1Y_MACRU 85.938 64 9 0 58 121 1 64 1.75E-33 118 UBE1Y_MACRU reviewed Ubiquitin-activating enzyme E1 Y (EC 6.2.1.45) (Fragment) UBE1Y SBY Macropus rufus (Red kangaroo) (Megaleia rufa) 152 protein ubiquitination [GO:0016567] GO:0005524; GO:0008641; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P22314}. 0 0 PF00899;PF10585; P48809 CHOYP_AAEL_AAEL008257.3.3 m.49114 sp RB27C_DROME 51.351 222 84 4 12 226 1 205 1.75E-68 225 RB27C_DROME reviewed Heterogeneous nuclear ribonucleoprotein 27C (Hrb27-C) (HRP48.1) (hnRNP 48) Hrb27C hrp48 Rbp7 CG10377 Drosophila melanogaster (Fruit fly) 421 "axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; lateral inhibition [GO:0046331]; negative regulation of oskar mRNA translation [GO:0007319]; pole plasm oskar mRNA localization [GO:0045451]; positive regulation of translation [GO:0045727]; regulation of mRNA splicing, via spliceosome [GO:0048024]" GO:0000166; GO:0003697; GO:0003729; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0007298; GO:0007319; GO:0007411; GO:0030529; GO:0043186; GO:0043234; GO:0045451; GO:0045727; GO:0046331; GO:0048024; GO:0048027 0 0 0 PF00076; P55043 CHOYP_LOC100865163.4.5 m.41645 sp RAD_RAT 37.791 172 98 4 135 301 89 256 1.75E-24 104 RAD_RAT reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) Rrad Rad Rattus norvegicus (Rat) 306 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; P58743 CHOYP_S26A5.2.2 m.9883 sp S26A5_HUMAN 31.893 787 456 18 38 813 17 734 1.75E-128 405 S26A5_HUMAN reviewed Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Homo sapiens (Human) 744 bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; fructose transport [GO:0015755]; negative regulation of ion transmembrane transport [GO:0034766]; positive regulation of cell motility [GO:2000147]; positive regulation of cell size [GO:0045793]; protein tetramerization [GO:0051262]; regulation of cell shape [GO:0008360]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; response to drug [GO:0042493]; response to ischemia [GO:0002931]; response to potassium ion [GO:0035864]; response to salicylic acid [GO:0009751]; response to salt [GO:1902074]; response to thyroid hormone [GO:0097066]; sensory perception of sound [GO:0007605] GO:0002931; GO:0005254; GO:0005737; GO:0005887; GO:0007605; GO:0008271; GO:0008360; GO:0009751; GO:0010996; GO:0015106; GO:0015116; GO:0015301; GO:0015701; GO:0015755; GO:0016323; GO:0016328; GO:0019531; GO:0034766; GO:0035864; GO:0042391; GO:0042493; GO:0045793; GO:0051262; GO:0051453; GO:0090102; GO:0097066; GO:1902074; GO:1902476; GO:2000147 0 0 0 PF01740;PF00916; P62184 CHOYP_CALM.41.50 m.55349 sp CALM_RENRE 55.484 155 60 3 2 155 3 149 1.75E-50 161 CALM_RENRE reviewed Calmodulin (CaM) 0 Renilla reniformis (Sea pansy) 149 0 GO:0005509 0 0 0 PF13499; P62494 CHOYP_NAEGRDRAFT_59420.1.2 m.29473 sp RB11A_RAT 36.058 208 121 3 12 214 12 212 1.75E-37 134 RB11A_RAT reviewed Ras-related protein Rab-11A (Rab-11) (24KG) Rab11a Rab11 Rattus norvegicus (Rat) 216 astral microtubule organization [GO:0030953]; cytokinesis [GO:0000910]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of multivesicular body size [GO:0010796]; regulation of protein transport [GO:0051223]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264] GO:0000910; GO:0000922; GO:0003924; GO:0005525; GO:0005739; GO:0005771; GO:0005802; GO:0005813; GO:0005828; GO:0005886; GO:0006887; GO:0007080; GO:0007264; GO:0010634; GO:0010796; GO:0010971; GO:0015031; GO:0030133; GO:0030424; GO:0030953; GO:0031175; GO:0032154; GO:0032402; GO:0036258; GO:0043234; GO:0045335; GO:0045773; GO:0048169; GO:0048471; GO:0051223; GO:0055037; GO:0055038; GO:0060627; GO:0070062; GO:0072594; GO:0072659; GO:0090150; GO:0090307; GO:1990182 0 0 0 PF00071; P70318 CHOYP_LOC659024.2.2 m.46850 sp TIAR_MOUSE 56.475 278 105 4 9 285 65 327 1.75E-97 296 TIAR_MOUSE reviewed Nucleolysin TIAR (TIA-1-related protein) Tial1 Mus musculus (Mouse) 392 apoptotic process [GO:0006915]; germ cell development [GO:0007281]; positive regulation of cell proliferation [GO:0008284]; stem cell division [GO:0017145] GO:0000166; GO:0005634; GO:0005737; GO:0006915; GO:0007281; GO:0008284; GO:0010494; GO:0017091; GO:0017145; GO:0044822; GO:0070062 0 0 0 PF00076; Q0VD23 CHOYP_RFOX2.2.2 m.59226 sp RFOX3_BOVIN 55.172 87 31 3 102 187 60 139 1.75E-19 89 RFOX3_BOVIN reviewed RNA binding protein fox-1 homolog 3 (Fox-1 homolog C) RBFOX3 Bos taurus (Bovine) 328 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003729; GO:0005634; GO:0005737; GO:0006397; GO:0008380 0 0 0 PF12414;PF00076; Q16534 CHOYP_contig_044466 m.51478 sp HLF_HUMAN 45.946 74 40 0 240 313 205 278 1.75E-11 67.4 HLF_HUMAN reviewed Hepatic leukemia factor HLF Homo sapiens (Human) 295 multicellular organism development [GO:0007275]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000977; GO:0001077; GO:0003677; GO:0003690; GO:0005634; GO:0006366; GO:0007275; GO:0035914; GO:0048511 0 0 0 PF07716; Q24488 CHOYP_LOC100533372.1.1 m.4509 sp ROR1_DROME 47.945 292 142 4 210 500 400 682 1.75E-89 291 ROR1_DROME reviewed Tyrosine-protein kinase transmembrane receptor Ror (dRor) (EC 2.7.10.1) Ror CG4926 Drosophila melanogaster (Fruit fly) 685 central nervous system development [GO:0007417]; protein phosphorylation [GO:0006468]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004713; GO:0004714; GO:0005524; GO:0006468; GO:0007169; GO:0007417; GO:0016021 0 0 0 PF00051;PF07714; Q2I6J0 CHOYP_INPPL1.1.1 m.18145 sp SHP2B_DANRE 29.63 324 191 7 1 318 1 293 1.75E-30 125 SHP2B_DANRE reviewed "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1B) (INPPL-1B) (SH2 domain-containing inositol 5'-phosphatase 2B) (SH2 domain-containing inositol phosphatase 2B) (SHIP-2B)" inppl1b inppl1 ship2b Danio rerio (Zebrafish) (Brachydanio rerio) 1226 cell adhesion [GO:0007155]; immune system process [GO:0002376]; phosphatidylinositol dephosphorylation [GO:0046856] GO:0002376; GO:0005829; GO:0005856; GO:0007155; GO:0016020; GO:0016787; GO:0030027; GO:0030175; GO:0046856 0 0 0 PF00536;PF00017; Q5R7J6 CHOYP_UBE2N.1.1 m.62056 sp UBE2N_PONAB 89.865 148 15 0 1 148 1 148 1.75E-99 285 UBE2N_PONAB reviewed Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme N) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) UBE2N Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 152 DNA repair [GO:0006281]; protein K63-linked ubiquitination [GO:0070534]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0004842; GO:0005524; GO:0005634; GO:0006281; GO:0006511; GO:0035370; GO:0061631; GO:0070534 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q5RAS6 CHOYP_LOC100747173.1.2 m.27916 sp COPT1_PONAB 44.162 197 97 5 26 216 1 190 1.75E-42 144 COPT1_PONAB reviewed High affinity copper uptake protein 1 (Copper transporter 1) (Solute carrier family 31 member 1) SLC31A1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 190 0 GO:0005375; GO:0005886; GO:0016021 0 0 0 PF04145; Q5SPP0 CHOYP_CLVS2.1.1 m.24440 sp CLVS2_DANRE 54.61 282 125 1 9 290 1 279 1.75E-109 323 CLVS2_DANRE reviewed Clavesin-2 (Retinaldehyde-binding protein 1-like 2) clvs2 rlbp1l2 si:ch211-199i15.4 Danio rerio (Zebrafish) (Brachydanio rerio) 329 lysosome organization [GO:0007040] GO:0005215; GO:0005768; GO:0005802; GO:0007040; GO:0008289; GO:0030136; GO:0031901; GO:0080025 0 0 0 PF00650;PF03765; Q5ZID2 CHOYP_PDCD2L.1.1 m.43699 sp PDD2L_CHICK 34.293 417 198 13 18 425 30 379 1.75E-64 214 PDD2L_CHICK reviewed Programmed cell death protein 2-like PDCD2L RCJMB04_27n18 Gallus gallus (Chicken) 379 0 GO:0005737 0 0 0 PF04194; Q66H85 CHOYP_ANKZF1.1.1 m.24990 sp ANKZ1_RAT 30.182 550 287 16 97 614 28 512 1.75E-59 220 ANKZ1_RAT reviewed Ankyrin repeat and zinc finger domain-containing protein 1 Ankzf1 Rattus norvegicus (Rat) 722 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; mitochondria-associated ubiquitin-dependent protein catabolic process [GO:0072671]; nucleus-associated proteasomal ubiquitin-dependent protein catabolic process [GO:0071630] GO:0030433; GO:0036266; GO:0046872; GO:0071630; GO:0072671 0 0 0 PF00023; Q6DGW9 CHOYP_DGRI_GH10893.1.1 m.27211 sp TMCO1_DANRE 77.473 182 40 1 20 200 2 183 1.75E-93 273 TMCO1_DANRE reviewed Calcium load-activated calcium channel (CLAC channel) (Transmembrane and coiled-coil domain-containing protein 1) tmco1 Danio rerio (Zebrafish) (Brachydanio rerio) 188 calcium ion transmembrane transport [GO:0070588]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983] GO:0000139; GO:0005262; GO:0006983; GO:0030176; GO:0032469; GO:0070588 0 0 0 PF01956; Q6DIM3 CHOYP_LOC100378272.1.1 m.12594 sp TBD_XENTR 52.527 455 202 3 1 445 1 451 1.75E-180 514 TBD_XENTR reviewed Tubulin delta chain (Delta-tubulin) tubd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005814; GO:0005874; GO:0007017 0 0 0 PF00091; Q6P806 CHOYP_SAM50.1.1 m.42680 sp SAM50_XENTR 46.714 426 222 5 17 440 46 468 1.75E-132 392 SAM50_XENTR reviewed Sorting and assembly machinery component 50 homolog samm50 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 468 cristae formation [GO:0042407] GO:0005741; GO:0016021; GO:0042407 0 0 0 PF01103; Q7F0J0 CHOYP_CALM.29.50 m.38472 sp CML13_ORYSJ 32.394 142 94 2 28 169 23 162 1.75E-18 80.9 CML13_ORYSJ reviewed Probable calcium-binding protein CML13 (Calmodulin-like protein 13) CML13 Os07g0618800 LOC_Os07g42660 P0552F09.133 P0560B08.106 Oryza sativa subsp. japonica (Rice) 169 0 GO:0005509 0 0 0 PF13499; Q7TN88 CHOYP_LOC100378512.6.6 m.55333 sp PK1L2_MOUSE 26.869 428 275 8 153 570 1807 2206 1.75E-34 143 PK1L2_MOUSE reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) 2461 detection of mechanical stimulus [GO:0050982] GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q7Z5L3 CHOYP_C1QL2.21.32 m.41857 sp C1QL2_HUMAN 33.594 128 80 3 295 419 159 284 1.75E-10 65.1 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q8BKE6 CHOYP_ND1.3.5 m.37623 sp CP20A_MOUSE 36.09 133 83 2 19 151 1 131 1.75E-19 88.2 CP20A_MOUSE reviewed Cytochrome P450 20A1 (EC 1.14.-.-) Cyp20a1 Mus musculus (Mouse) 462 0 GO:0004497; GO:0005506; GO:0016020; GO:0016021; GO:0016705; GO:0020037 0 0 0 PF00067; Q99315 CHOYP_LOC100004631.1.1 m.36550 sp YG31B_YEAST 28.533 750 471 17 443 1156 602 1322 1.75E-83 305 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9CZC8 CHOYP_LOC100373892.1.2 m.44404 sp SCRN1_MOUSE 37.799 418 221 10 8 400 10 413 1.75E-77 248 SCRN1_MOUSE reviewed Secernin-1 Scrn1 Kiaa0193 Mus musculus (Mouse) 414 exocytosis [GO:0006887] GO:0005634; GO:0005737; GO:0006887; GO:0016805; GO:0031965 0 0 0 PF03577; Q9XT77 CHOYP_BRAFLDRAFT_213839.2.2 m.55857 sp SC5A6_RABIT 42.439 615 334 7 16 625 23 622 1.75E-153 460 SC5A6_RABIT reviewed Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) SLC5A6 SMVT Oryctolagus cuniculus (Rabbit) 636 sodium ion transport [GO:0006814] GO:0006814; GO:0015293; GO:0016021 0 0 0 PF00474; Q9Y485 CHOYP_LOC100533258.3.6 m.13714 sp DMXL1_HUMAN 62.857 70 26 0 13 82 591 660 1.75E-25 102 DMXL1_HUMAN reviewed DmX-like protein 1 (X-like 1 protein) DMXL1 XL1 Homo sapiens (Human) 3027 0 0 0 0 0 PF12234;PF00400; A0KDV2 CHOYP_MONBRDRAFT_34536.1.1 m.30219 sp RHMD_BURCH 52.897 397 178 4 11 406 3 391 1.76E-148 430 RHMD_BURCH reviewed L-rhamnonate dehydratase (RhamD) (EC 4.2.1.90) rhmD Bcen2424_6636 Burkholderia cenocepacia (strain HI2424) 392 cellular amino acid catabolic process [GO:0009063] GO:0000287; GO:0009063; GO:0050032 0 0 0 PF13378;PF02746; B5DF93 CHOYP_BRAFLDRAFT_119484.2.3 m.60445 sp PATL1_RAT 36.967 422 235 12 432 837 360 766 1.76E-59 219 PATL1_RAT reviewed Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) Patl1 Rattus norvegicus (Rat) 770 cytoplasmic mRNA processing body assembly [GO:0033962]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290] GO:0000290; GO:0000932; GO:0003723; GO:0008266; GO:0016605; GO:0016607; GO:0030014; GO:0033962; GO:0034046; GO:0044822 0 0 0 PF09770; D3YXG0 CHOYP_BRAFLDRAFT_236936.4.6 m.48049 sp HMCN1_MOUSE 49.782 229 113 2 646 874 4642 4868 1.76E-68 254 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; F1QFR9 CHOYP_LOC100373169.1.1 m.15574 sp PSM4A_DANRE 41.049 324 164 6 3 316 1446 1752 1.76E-69 240 PSM4A_DANRE reviewed Proteasome activator complex subunit 4A (Proteasome activator PA200-A) psme4a Danio rerio (Zebrafish) (Brachydanio rerio) 1833 "cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]" GO:0005634; GO:0005829; GO:0006281; GO:0006974; GO:0010499; GO:0016504; GO:0016607; GO:0035093; GO:0070577; GO:1990111 0 0 0 PF16507;PF11919; O16025 CHOYP_LOC584481.8.10 m.61433 sp AOSL_PLEHO 33.286 703 414 19 4 663 376 1066 1.76E-111 363 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O35920 CHOYP_CAN8.1.2 m.21091 sp CAN9_RAT 35.87 460 260 15 241 674 37 487 1.76E-73 257 CAN9_RAT reviewed Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) Capn9 Ncl4 Rattus norvegicus (Rat) 690 digestion [GO:0007586] GO:0004198; GO:0005509; GO:0005737; GO:0007586 0 0 0 PF01067;PF13833;PF00648; O54750 CHOYP_BRAFLDRAFT_278496.1.1 m.17793 sp CP2J6_MOUSE 35.091 493 303 10 12 498 20 501 1.76E-91 290 CP2J6_MOUSE reviewed Cytochrome P450 2J6 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ6) Cyp2j6 Mus musculus (Mouse) 501 arachidonic acid metabolic process [GO:0019369]; epoxygenase P450 pathway [GO:0019373]; linoleic acid metabolic process [GO:0043651] GO:0005506; GO:0005783; GO:0005789; GO:0008392; GO:0008395; GO:0008404; GO:0008405; GO:0019369; GO:0019373; GO:0020037; GO:0031090; GO:0043651; GO:0070062; GO:0070330; GO:0071614 0 0 0 PF00067; O88799 CHOYP_LOC100224009.1.1 m.29070 sp ZAN_MOUSE 27.74 447 251 12 1 443 1390 1768 1.76E-44 170 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; O89016 CHOYP_ABCD4.2.2 m.17030 sp ABCD4_MOUSE 45.098 306 163 3 13 316 13 315 1.76E-87 278 ABCD4_MOUSE reviewed ATP-binding cassette sub-family D member 4 (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69) Abcd4 Pxmp1l Mus musculus (Mouse) 606 cobalamin metabolic process [GO:0009235] GO:0005524; GO:0005789; GO:0009235; GO:0016021; GO:0042626 0 0 0 PF06472;PF00005; O94759 CHOYP_TRPM2.1.12 m.22527 sp TRPM2_HUMAN 25.373 670 385 19 404 994 485 1118 1.76E-40 166 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; O94889 CHOYP_KLHDB.3.5 m.46662 sp KLH18_HUMAN 22.93 628 388 18 571 1189 9 549 1.76E-36 150 KLH18_HUMAN reviewed Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) 574 protein ubiquitination [GO:0016567] GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; O95466 CHOYP_FMNL1.1.1 m.59748 sp FMNL1_HUMAN 30.127 395 263 7 438 821 633 1025 1.76E-47 188 FMNL1_HUMAN reviewed Formin-like protein 1 (CLL-associated antigen KW-13) (Leukocyte formin) FMNL1 C17orf1 C17orf1B FMNL FRL1 Homo sapiens (Human) 1100 actin filament severing [GO:0051014]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell shape [GO:0008360]; substrate-dependent cell migration [GO:0006929] GO:0005829; GO:0005886; GO:0005938; GO:0006929; GO:0008360; GO:0016020; GO:0030866; GO:0032059; GO:0032794; GO:0045335; GO:0048365; GO:0051014; GO:0051015; GO:0070062 0 0 0 PF06367;PF06371;PF02181; P00378 CHOYP_BRAFLDRAFT_268308.1.1 m.17043 sp DYR_CHICK 47.253 182 93 3 38 217 4 184 1.76E-52 171 DYR_CHICK reviewed Dihydrofolate reductase (EC 1.5.1.3) DHFR Gallus gallus (Chicken) 189 glycine biosynthetic process [GO:0006545]; nucleotide biosynthetic process [GO:0009165]; one-carbon metabolic process [GO:0006730]; response to methotrexate [GO:0031427]; tetrahydrofolate biosynthetic process [GO:0046654]; tetrahydrofolate metabolic process [GO:0046653] GO:0003729; GO:0004146; GO:0006545; GO:0006730; GO:0008144; GO:0009165; GO:0031427; GO:0046653; GO:0046654; GO:0050661 "PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1." 0 cd00209; PF00186; P00428 CHOYP_COX5B.2.3 m.30658 sp COX5B_BOVIN 44.565 92 46 3 86 176 35 122 1.76E-18 80.1 COX5B_BOVIN reviewed "Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide VIa) (Cytochrome c oxidase polypeptide Vb)" COX5B Bos taurus (Bovine) 129 0 GO:0004129; GO:0005743; GO:0045277; GO:0046872 0 0 cd00924; PF01215; P0C5E4 CHOYP_LOC101072911.1.1 m.31574 sp PTPRQ_MOUSE 22.194 392 233 15 15 352 391 764 1.76E-09 63.2 PTPRQ_MOUSE reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Mus musculus (Mouse) 2300 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598]; vestibular receptor cell morphogenesis [GO:0060116] GO:0002244; GO:0004725; GO:0016021; GO:0032421; GO:0042472; GO:0045598; GO:0046856; GO:0050885; GO:0050910; GO:0060116 0 0 0 PF00041;PF00102; P12032 CHOYP_TIMP2.2.3 m.40746 sp TIMP1_MOUSE 26.519 181 115 9 24 191 25 200 1.76E-06 50.1 TIMP1_MOUSE reviewed Metalloproteinase inhibitor 1 (Collagenase inhibitor 16C8 fibroblast) (Erythroid-potentiating activity) (EPA) (TPA-S1) (TPA-induced protein) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) Timp1 Timp Timp-1 Mus musculus (Mouse) 205 aging [GO:0007568]; cartilage development [GO:0051216]; cell activation [GO:0001775]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of trophoblast cell migration [GO:1901164]; positive regulation of cell proliferation [GO:0008284]; regulation of integrin-mediated signaling pathway [GO:2001044]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to peptide hormone [GO:0043434]; wound healing [GO:0042060] GO:0001775; GO:0002020; GO:0005125; GO:0005578; GO:0005604; GO:0005615; GO:0007568; GO:0008191; GO:0008284; GO:0009725; GO:0010951; GO:0034097; GO:0042060; GO:0043066; GO:0043086; GO:0043434; GO:0046872; GO:0051045; GO:0051216; GO:0070062; GO:1901164; GO:2001044 0 0 0 PF00965; P12276 CHOYP_FASN.4.4 m.66455 sp FAS_CHICK 47.143 140 74 0 38 177 820 959 1.76E-39 146 FAS_CHICK reviewed Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Gallus gallus (Chicken) 2512 fatty acid biosynthetic process [GO:0006633]; lactate metabolic process [GO:0006089]; positive regulation of appetite [GO:0032100] GO:0003697; GO:0004312; GO:0004313; GO:0004314; GO:0004315; GO:0004316; GO:0004317; GO:0004319; GO:0004320; GO:0005623; GO:0006089; GO:0006633; GO:0016295; GO:0016296; GO:0031177; GO:0032100; GO:0047117; GO:0047451; GO:0102132 0 0 0 PF00698;PF00107;PF16197;PF00109;PF02801;PF08659;PF00550;PF14765;PF00975; P16066 CHOYP_LOC100868794.1.1 m.38566 sp ANPRA_HUMAN 35.526 456 271 10 91 536 92 534 1.76E-85 294 ANPRA_HUMAN reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) NPR1 ANPRA Homo sapiens (Human) 1061 body fluid secretion [GO:0007589]; cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of urine volume [GO:0035810]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of vascular permeability [GO:0043114]; regulation of vasodilation [GO:0042312] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007166; GO:0007168; GO:0007589; GO:0008074; GO:0008217; GO:0008528; GO:0016525; GO:0016941; GO:0017046; GO:0030308; GO:0030828; GO:0035556; GO:0035810; GO:0035815; GO:0042312; GO:0042417; GO:0042562; GO:0043114; GO:0043235; GO:0048662; GO:1903779 0 0 0 PF01094;PF00211;PF07714; P21613 CHOYP_KINH.5.9 m.39139 sp KINH_DORPE 69.014 213 60 2 39 251 725 931 1.76E-82 270 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P22856 CHOYP_PVX_111155.1.1 m.25208 sp VL96_IRV1 28.834 163 89 5 160 307 595 745 1.76E-10 67.4 VL96_IRV1 reviewed Putative ubiquitin thioesterase L96 (EC 3.4.19.12) L96 Tipula iridescent virus (TIV) (Insect iridescent virus type 1) 867 "DNA-templated transcription, termination [GO:0006353]; viral release from host cell [GO:0019076]" GO:0003677; GO:0006353; GO:0019076; GO:0036459 0 0 0 PF02338; P24044 CHOYP_CALM.18.50 m.30600 sp CALM_PLAFA 51.389 144 69 1 3 146 4 146 1.76E-46 150 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; P35822 CHOYP_PTPRZ.8.9 m.42918 sp PTPRK_MOUSE 39.016 305 176 4 1 297 990 1292 1.76E-61 214 PTPRK_MOUSE reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) Ptprk Ptpk Mus musculus (Mouse) 1457 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005911; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; P87239 CHOYP_CBEI_4404.1.1 m.987 sp MDJ1_SCHPO 50 72 36 0 30 101 84 155 1.76E-13 72.4 MDJ1_SCHPO reviewed "DnaJ homolog 1, mitochondrial" mdj1 SPCC4G3.14 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 528 protein folding [GO:0006457]; response to heat [GO:0009408] GO:0005524; GO:0005739; GO:0006457; GO:0009408; GO:0046872 0 0 cd06257; PF00226;PF01556;PF00684; Q03132 CHOYP_LOC100922325.2.2 m.38650 sp ERYA2_SACER 28.064 1126 731 29 7 1091 1491 2578 1.76E-130 450 ERYA2_SACER reviewed "6-deoxyerythronolide-B synthase EryA2, modules 3 and 4 (DEBS 2) (EC 2.3.1.94) (6-deoxyerythronolide B synthase II) (Erythronolide synthase) (ORF B)" eryA Saccharopolyspora erythraea (Streptomyces erythraeus) 3567 macrolide biosynthetic process [GO:0033068] GO:0016491; GO:0031177; GO:0033068; GO:0047879; GO:0048037 "PATHWAY: Antibiotic biosynthesis; erythromycin biosynthesis. {ECO:0000305|PubMed:17328673, ECO:0000305|PubMed:21095573}." 0 0 PF00698;PF08240;PF00107;PF08990;PF09277;PF16197;PF00109;PF02801;PF08659;PF00550;PF14765; Q14162 CHOYP_PEAR1.7.16 m.38377 sp SREC_HUMAN 34.146 123 63 3 172 279 270 389 1.76E-10 65.5 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q3SWX0 CHOYP_NIPAL1.1.1 m.14654 sp NIPA2_BOVIN 69.863 73 22 0 42 114 9 81 1.76E-29 111 NIPA2_BOVIN reviewed Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog) NIPA2 Bos taurus (Bovine) 360 magnesium ion transport [GO:0015693] GO:0005769; GO:0005886; GO:0015095; GO:0015693; GO:0016021 0 0 0 PF05653; Q4AE62 CHOYP_BRAFLDRAFT_120634.1.1 m.17534 sp GTDC1_HUMAN 46.753 462 208 5 12 472 4 428 1.76E-145 427 GTDC1_HUMAN reviewed Glycosyltransferase-like domain-containing protein 1 (Mannosyltransferase-like protein Xa) (Mat-Xa) GTDC1 Homo sapiens (Human) 458 0 GO:0016757 0 0 0 PF12038;PF00534; Q4UMH6 CHOYP_LOC755594.6.6 m.57652 sp Y381_RICFE 26.994 326 215 8 947 1269 665 970 1.76E-23 112 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q54JW9 CHOYP_DEHA2B05830G.1.1 m.20387 sp IMPCT_DICDI 34.259 108 70 1 40 146 214 321 1.76E-16 78.2 IMPCT_DICDI reviewed Protein IMPACT homolog impact DDB_G0287757 Dictyostelium discoideum (Slime mold) 345 cell differentiation [GO:0030154]; cellular response to acidic pH [GO:0071468]; cellular response to amino acid starvation [GO:0034198]; cellular response to benomyl [GO:0072755]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of cell death [GO:0060548]; nervous system development [GO:0007399]; regulation of translation [GO:0006417] GO:0005737; GO:0006417; GO:0007399; GO:0030154; GO:0034198; GO:0060548; GO:0070301; GO:0071468; GO:0072755 0 0 0 PF05773;PF01205; Q54P70 CHOYP_DICPUDRAFT_75027.2.3 m.33958 sp Y4757_DICDI 31.159 138 87 4 453 588 634 765 1.76E-11 72.4 Y4757_DICDI reviewed OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) 766 0 GO:0008234 0 0 0 PF02338; Q5BIM1 CHOYP_NEMVEDRAFT_V1G42184.1.1 m.19966 sp TRI45_BOVIN 24.586 362 214 12 14 341 27 363 1.76E-15 81.6 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5DTT8 CHOYP_LOC100890160.2.4 m.19192 sp PNMA5_MOUSE 28.082 146 93 3 1 134 159 304 1.76E-07 55.8 PNMA5_MOUSE reviewed Paraneoplastic antigen-like protein 5 Pnma5 Kiaa1934 Mus musculus (Mouse) 618 0 GO:0042802 0 0 0 PF14893; Q5I0X7 CHOYP_TTC32.2.2 m.63842 sp TTC32_HUMAN 47.253 91 48 0 18 108 55 145 1.76E-20 83.2 TTC32_HUMAN reviewed Tetratricopeptide repeat protein 32 (TPR repeat protein 32) TTC32 Homo sapiens (Human) 151 0 0 0 0 0 PF00515; Q6AYG0 CHOYP_LOC100370823.2.3 m.34040 sp RRNAD_RAT 32.51 243 128 6 14 244 15 233 1.76E-30 125 RRNAD_RAT reviewed Protein RRNAD1 Rrnad1 Rattus norvegicus (Rat) 475 0 GO:0016021 0 0 0 PF13679; Q6IQ97 CHOYP_LOC100708853.1.3 m.18743 sp RBM41_DANRE 54.167 72 33 0 3 74 2 73 1.76E-21 96.7 RBM41_DANRE reviewed RNA-binding protein 4.1 (RNA-binding motif protein 4.1) rbm4.1 rbm4 Danio rerio (Zebrafish) (Brachydanio rerio) 419 0 GO:0000166; GO:0003723; GO:0005634; GO:0008270 0 0 0 PF00076;PF00098; Q75W84 CHOYP_ANR.1.1 m.43519 sp ANR_EISFE 43.333 330 131 6 2 280 77 401 1.76E-81 256 ANR_EISFE reviewed Annetocin receptor anr Eisenia fetida (Red wiggler worm) 420 G-protein coupled receptor signaling pathway [GO:0007186]; oviposition [GO:0018991] GO:0005000; GO:0005886; GO:0007186; GO:0016021; GO:0016500; GO:0018991 0 0 0 PF00001; Q7QEH1 CHOYP_RS14.4.6 m.40951 sp RS14A_ANOGA 97.895 95 2 0 15 109 58 152 1.76E-61 187 RS14A_ANOGA reviewed 40S ribosomal protein S14a RpS14a AGAP000655 Anopheles gambiae (African malaria mosquito) 152 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]" GO:0000028; GO:0000462; GO:0003735; GO:0006412; GO:0022627; GO:0048027; GO:0070181 0 0 0 PF00411; Q8TDX9 CHOYP_LOC100375380.2.4 m.42897 sp PK1L1_HUMAN 25.493 1420 863 42 38 1385 699 1995 1.76E-106 378 PK1L1_HUMAN reviewed Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1) PKD1L1 UNQ5785/PRO19563 Homo sapiens (Human) 2849 detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986]; single organismal cell-cell adhesion [GO:0016337] GO:0003127; GO:0005262; GO:0005929; GO:0016020; GO:0016337; GO:0031513; GO:0034704; GO:0050982; GO:0060170; GO:0070986 0 0 0 PF00801;PF08016;PF01477;PF02010; Q923Y8 CHOYP_TAAR1.1.1 m.48576 sp TAAR1_MOUSE 22.819 298 200 7 4 279 12 301 1.76E-10 64.7 TAAR1_MOUSE reviewed Trace amine-associated receptor 1 (TaR-1) (Trace amine receptor 1) Taar1 Ta1 Tar1 Trar1 Mus musculus (Mouse) 332 adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; cAMP biosynthetic process [GO:0006171]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0001594; GO:0005886; GO:0006171; GO:0007186; GO:0007191; GO:0008227; GO:0016021 0 0 0 PF00001; Q92734 CHOYP_TFG.1.1 m.8487 sp TFG_HUMAN 51.613 217 80 6 1 205 5 208 1.76E-58 201 TFG_HUMAN reviewed Protein TFG (TRK-fused gene protein) TFG Homo sapiens (Human) 400 COPII vesicle coating [GO:0048208]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0000139; GO:0004871; GO:0005737; GO:0005829; GO:0042802; GO:0043123; GO:0048208; GO:0070062 0 0 0 PF00564; Q96AY4 CHOYP_LOC100368841.1.1 m.29637 sp TTC28_HUMAN 21.113 611 386 21 439 1011 554 1106 1.76E-10 69.7 TTC28_HUMAN reviewed Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio) TTC28 KIAA1043 TPRBK Homo sapiens (Human) 2481 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of mitotic cell cycle [GO:0007346] GO:0000922; GO:0005737; GO:0005813; GO:0007067; GO:0007346; GO:0030496; GO:0051301 0 0 0 PF12770;PF13176;PF13181; Q96MM6 CHOYP_BRAFLDRAFT_242762.8.8 m.63468 sp HS12B_HUMAN 27.9 638 368 19 20 579 59 682 1.76E-69 240 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BMX5 CHOYP_RS6.10.12 m.44863 sp RS6_APLCA 80.579 242 42 1 1 242 1 237 1.76E-141 403 RS6_APLCA reviewed 40S ribosomal protein S6 RPS6 Aplysia californica (California sea hare) 247 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01092; Q9CY57 CHOYP_contig_002610 m.2872 sp CHTOP_MOUSE 72.727 44 12 0 5 48 46 89 1.76E-12 66.6 CHTOP_MOUSE reviewed Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) Chtop Fop MNCb-1706 Mus musculus (Mouse) 249 "mRNA export from nucleus [GO:0006406]; positive regulation of ATPase activity [GO:0032781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of helicase activity [GO:0051096]; positive regulation of histone methylation [GO:0031062]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000346; GO:0005730; GO:0006351; GO:0006355; GO:0006406; GO:0008284; GO:0008327; GO:0016607; GO:0031062; GO:0032781; GO:0044822; GO:0051096 0 0 0 PF13865; Q9ESN6 CHOYP_TRIM3.35.58 m.38996 sp TRIM2_MOUSE 28.163 245 157 10 150 382 505 742 1.76E-16 84.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9P3K8 CHOYP_TRIADDRAFT_59935.1.1 m.4972 sp MCH1_NEUCR 23.429 525 289 21 19 450 60 564 1.76E-13 76.3 MCH1_NEUCR reviewed Probable transporter mch1 mch1 B15I20.030 NCU16534 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 598 transmembrane transport [GO:0055085] GO:0005774; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q9QZN9 CHOYP_LOC565564.1.1 m.36248 sp CNR2_RAT 21.988 332 212 12 32 334 43 356 1.76E-09 62.4 CNR2_RAT reviewed Cannabinoid receptor 2 (CB-2) (CB2) (rCB2) Cnr2 Rattus norvegicus (Rat) 360 "G-protein coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of action potential [GO:0045759]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell activation [GO:0033004]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; response to amphetamine [GO:0001975]; response to lipopolysaccharide [GO:0032496]; sensory perception of pain [GO:0019233]" GO:0001975; GO:0004930; GO:0004949; GO:0006954; GO:0007186; GO:0016021; GO:0019233; GO:0030425; GO:0031234; GO:0032229; GO:0032496; GO:0033004; GO:0043005; GO:0043025; GO:0043204; GO:0045759; GO:0050728; GO:0051001 0 0 0 PF00001; Q9YHV4 CHOYP_LOC100695151.1.2 m.7043 sp FSTA_DANRE 30.081 123 54 5 15 133 134 228 1.76E-07 52.8 FSTA_DANRE reviewed Follistatin-A (FS) (Activin-binding protein) (Follistatin-1) (zFst1) fsta fst fst1 si:dkey-111k10.2 si:dkeyp-88a5.1 Danio rerio (Zebrafish) (Brachydanio rerio) 322 determination of dorsal identity [GO:0048263]; dorsal/ventral pattern formation [GO:0009953]; embryonic viscerocranium morphogenesis [GO:0048703]; midbrain development [GO:0030901]; oocyte differentiation [GO:0009994]; otic placode formation [GO:0043049] GO:0005576; GO:0009953; GO:0009994; GO:0030901; GO:0043049; GO:0048263; GO:0048703 0 0 0 PF09289;PF07648; Q9YIC0 CHOYP_EF-1A.1.9 m.5616 sp EF1A_ORYLA 90.323 93 9 0 7 99 228 320 1.76E-52 173 EF1A_ORYLA reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; A5PLK6 CHOYP_LOC100376370.1.2 m.49263 sp RGSL_HUMAN 37.5 80 47 2 17 95 11 88 1.77E-07 52.8 RGSL_HUMAN reviewed Regulator of G-protein signaling protein-like RGSL1 RGSL RGSL2 Homo sapiens (Human) 1076 0 GO:0005096; GO:0005737; GO:0005886; GO:0016021 0 0 0 PF00615; A5PMU4 CHOYP_LOC101076145.1.1 m.26253 sp ANS1B_DANRE 36.667 90 50 3 1 90 225 307 1.77E-08 60.1 ANS1B_DANRE reviewed Ankyrin repeat and sterile alpha motif domain-containing protein 1B anks1b si:ch211-211o1.2 si:dkey-11k24.3 Danio rerio (Zebrafish) (Brachydanio rerio) 1280 regulation of synaptic plasticity by receptor localization to synapse [GO:1900383] GO:0005737; GO:1900383 0 0 0 PF12796;PF00640;PF00536;PF07647; A5YM72 CHOYP_HSP7D.2.3 m.34789 sp CRNS1_HUMAN 32.967 91 59 1 20 108 236 326 1.77E-06 48.9 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A7MBF6 CHOYP_LOC100375249.1.1 m.18861 sp CA228_BOVIN 55.556 405 179 1 1 404 1 405 1.77E-166 477 CA228_BOVIN reviewed Uncharacterized protein C1orf228 homolog 0 Bos taurus (Bovine) 442 0 0 0 0 0 0 D8VNS8 CHOYP_BRAFLDRAFT_86061.2.13 m.21248 sp FCNV2_CERRY 50.562 178 86 2 100 275 143 320 1.77E-57 191 FCNV2_CERRY reviewed Ryncolin-2 0 Cerberus rynchops (Dog-faced water snake) 347 0 GO:0005576 0 0 0 PF01391;PF00147; G5EBN9 CHOYP_DGRI_GH22876.3.3 m.59754 sp SNF3_CAEEL 55 60 16 2 84 135 3 59 1.77E-13 69.3 SNF3_CAEEL reviewed Sodium- and chloride-dependent betaine transporter (Betaine transporter SNF-3) (Na(+)/Cl(-) betaine/GABA transporter) (Sodium:neurotransmitter symporter family protein 3) snf-3 bgt-1 T13B5.1 Caenorhabditis elegans 600 amino-acid betaine transport [GO:0015838]; transport [GO:0006810] GO:0005215; GO:0005328; GO:0005887; GO:0006810; GO:0015199; GO:0015838 0 0 0 PF00209; I1VZH0 CHOYP_LOC100374741.23.83 m.21264 sp RN207_RABIT 22.527 182 129 5 1 180 123 294 1.77E-06 53.9 RN207_RABIT reviewed RING finger protein 207 RNF207 Oryctolagus cuniculus (Rabbit) 594 0 GO:0005737; GO:0008270 0 0 0 PF00643; O42227 CHOYP_BRAFLDRAFT_217516.1.1 m.18629 sp HDA1B_XENLA 84.946 186 28 0 1 186 205 390 1.77E-120 352 HDA1B_XENLA reviewed Probable histone deacetylase 1-B (HD1-B) (EC 3.5.1.98) (RPD3 homolog) hdac1-b Xenopus laevis (African clawed frog) 480 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0032041 0 0 0 PF00850; O43432 CHOYP_IF4G3.1.1 m.61316 sp IF4G3_HUMAN 47.706 109 52 3 7 110 693 801 1.77E-20 88.2 IF4G3_HUMAN reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) EIF4G3 Homo sapiens (Human) 1585 regulation of translational initiation [GO:0006446]; viral process [GO:0016032] GO:0000339; GO:0003743; GO:0005829; GO:0006446; GO:0008135; GO:0016032; GO:0016281; GO:0044822 0 0 0 PF02847;PF02854;PF02020; O70277 CHOYP_BRAFLDRAFT_87299.2.2 m.46265 sp TRIM3_RAT 28.333 120 83 2 71 188 625 743 1.77E-10 63.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_TRIM2.53.59 m.60082 sp TRIM3_RAT 29.167 120 80 3 39 155 627 744 1.77E-07 52.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O95613 CHOYP_LOC100368547.1.40 m.978 sp PCNT_HUMAN 61.29 62 23 1 33 93 3131 3192 1.77E-19 85.5 PCNT_HUMAN reviewed Pericentrin (Kendrin) (Pericentrin-B) PCNT KIAA0402 PCNT2 Homo sapiens (Human) 3336 cilium assembly [GO:0042384]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316] GO:0000086; GO:0000226; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0005874; GO:0007052; GO:0016020; GO:0034451; GO:0042384; GO:0090316 0 0 0 PF10495; P04758 CHOYP_ACHB3.2.5 m.37387 sp ACHB_BOVIN 31.953 338 194 11 20 331 21 348 1.77E-42 159 ACHB_BOVIN reviewed Acetylcholine receptor subunit beta CHRNB1 Bos taurus (Bovine) 505 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; cation transport [GO:0006812]; muscle contraction [GO:0006936]; muscle fiber development [GO:0048747]; neurological system process [GO:0050877]; neuromuscular synaptic transmission [GO:0007274]; postsynaptic membrane organization [GO:0001941]; regulation of membrane potential [GO:0042391]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0001941; GO:0004889; GO:0005892; GO:0006812; GO:0006936; GO:0007165; GO:0007271; GO:0007274; GO:0015267; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0042166; GO:0042391; GO:0045202; GO:0045211; GO:0048747; GO:0050877; GO:0098655 0 0 0 PF02931;PF02932; P15145 CHOYP_NEMVEDRAFT_V1G179195.1.1 m.40560 sp AMPN_PIG 34.945 910 545 18 143 1025 70 959 1.77E-177 546 AMPN_PIG reviewed Aminopeptidase N (AP-N) (pAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (gp130) (CD antigen CD13) ANPEP Sus scrofa (Pig) 963 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P24044 CHOYP_LOC100350107.1.1 m.12146 sp CALM_PLAFA 41.379 145 84 1 35 179 4 147 1.77E-36 127 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; P27600 CHOYP_LOC580791.1.1 m.51395 sp GNA12_MOUSE 65.294 340 116 1 28 365 40 379 1.77E-163 465 GNA12_MOUSE reviewed Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) Gna12 Gna-12 Mus musculus (Mouse) 379 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell differentiation [GO:0030154]; embryonic digit morphogenesis [GO:0042733]; G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]; response to drug [GO:0042493]; Rho protein signal transduction [GO:0007266] GO:0001701; GO:0003924; GO:0004871; GO:0005525; GO:0005834; GO:0005925; GO:0007186; GO:0007188; GO:0007266; GO:0008360; GO:0010762; GO:0030154; GO:0031526; GO:0031683; GO:0031752; GO:0032006; GO:0032434; GO:0035556; GO:0042493; GO:0042733; GO:0046872 0 0 0 PF00503; P31320 CHOYP_LOC100371136.4.5 m.53954 sp KAPR_BLAEM 25.738 237 146 5 6 241 131 338 1.77E-14 79 KAPR_BLAEM reviewed cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) PKAR Blastocladiella emersonii (Aquatic fungus) 403 0 GO:0005952; GO:0008603; GO:0030552 0 0 0 PF00027;PF02197; P43144 CHOYP_ACH10.2.2 m.62754 sp ACHA9_RAT 31.511 311 182 8 33 327 21 316 1.77E-39 151 ACHA9_RAT reviewed Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) Chrna9 Acra9 Rattus norvegicus (Rat) 479 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; sensory perception of sound [GO:0007605]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005829; GO:0005892; GO:0007204; GO:0007271; GO:0007605; GO:0022848; GO:0030054; GO:0042166; GO:0042472; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; P54318 CHOYP_BRAFLDRAFT_126555.1.6 m.3673 sp LIPR2_RAT 35.099 453 272 10 92 532 17 459 1.77E-86 278 LIPR2_RAT reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) (Secretory glycoprotein GP-3) Pnliprp2 Plrp2 Rattus norvegicus (Rat) 468 galactolipid catabolic process [GO:0019376]; phospholipid catabolic process [GO:0009395]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0009395; GO:0009791; GO:0016298; GO:0019376; GO:0032094; GO:0033993; GO:0042589; GO:0043434; GO:0047372; GO:0047714; GO:0051384 0 0 0 PF00151;PF01477; P86948 CHOYP_MP.4.4 m.41357 sp MP_PINMA 36.667 150 95 0 8 157 90 239 1.77E-17 79.7 MP_PINMA reviewed Mantle protein (MP) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 260 0 GO:0005576 0 0 0 0 Q02988 CHOYP_LOC100889113.1.1 m.47409 sp LECA_PLEWA 28.125 128 89 2 161 288 41 165 1.77E-09 59.3 LECA_PLEWA reviewed Lectin LEC Pleurodeles waltl (Iberian ribbed newt) 172 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q08E31 CHOYP_PKD1.1.3 m.37110 sp CREST_BOVIN 65.823 79 24 3 37 114 1 77 1.77E-23 105 CREST_BOVIN reviewed Calcium-responsive transactivator (SS18-like protein 1) SS18L1 CREST Bos taurus (Bovine) 402 "covalent chromatin modification [GO:0016569]; dendrite development [GO:0016358]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000777; GO:0000780; GO:0005634; GO:0006351; GO:0016358; GO:0016569; GO:0045893; GO:0050775; GO:0071565 0 0 0 PF05030; Q14094 CHOYP_ISCW_ISCW001340.1.1 m.1980 sp CCNI_HUMAN 36.875 320 148 4 44 310 44 362 1.77E-65 213 CCNI_HUMAN reviewed Cyclin-I CCNI Homo sapiens (Human) 377 regulation of cell cycle [GO:0051726]; spermatogenesis [GO:0007283] GO:0007283; GO:0051726 0 0 0 PF00134; Q15637 CHOYP_SF01.1.1 m.38010 sp SF01_HUMAN 64.615 65 23 0 50 114 15 79 1.77E-23 97.8 SF01_HUMAN reviewed Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) SF1 ZFM1 ZNF162 Homo sapiens (Human) 639 "Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription, DNA-templated [GO:0006355]; spliceosomal complex assembly [GO:0000245]; transcription, DNA-templated [GO:0006351]" GO:0000245; GO:0000389; GO:0000398; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005840; GO:0006351; GO:0006355; GO:0008270; GO:0030238; GO:0033327; GO:0042802; GO:0044822; GO:0048662; GO:0050810 0 0 0 PF00013;PF16275;PF00098; Q2T9Y1 CHOYP_CC026.1.1 m.27040 sp CC026_BOVIN 38.328 287 155 6 25 297 1 279 1.77E-51 173 CC026_BOVIN reviewed Uncharacterized protein C3orf26 homolog 0 Bos taurus (Bovine) 279 0 GO:0044822 0 0 0 PF14617; Q460N5 CHOYP_PARP14.3.22 m.20901 sp PAR14_HUMAN 32.889 225 130 6 6 227 1095 1301 1.77E-25 108 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4ZJM9 CHOYP_LOC100330792.1.2 m.48676 sp C1QL4_MOUSE 36.207 116 66 4 67 179 123 233 1.77E-09 58.5 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q53FA7 CHOYP_BRAFLDRAFT_57258.3.3 m.49524 sp QORX_HUMAN 56.495 331 139 4 72 398 1 330 1.77E-123 363 QORX_HUMAN reviewed Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein) TP53I3 PIG3 Homo sapiens (Human) 332 NADP metabolic process [GO:0006739]; regulation of apoptotic process [GO:0042981] GO:0003960; GO:0005829; GO:0006739; GO:0008270; GO:0042803; GO:0042981; GO:0048038; GO:0070062; GO:0070402 0 0 0 PF08240;PF00107; Q5FW12 CHOYP_LOC100376749.1.1 m.27252 sp TIPRL_XENTR 49.603 252 123 3 45 295 7 255 1.77E-94 283 TIPRL_XENTR reviewed TIP41-like protein tiprl Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 273 chordate embryonic development [GO:0043009]; negative regulation of apoptotic process [GO:0043066] GO:0005737; GO:0043009; GO:0043066 0 0 0 PF04176; Q5FWF5 CHOYP_ESCO1.1.1 m.15414 sp ESCO1_HUMAN 47.984 248 119 4 450 688 587 833 1.77E-75 262 ESCO1_HUMAN reviewed N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) ESCO1 EFO1 KIAA1911 Homo sapiens (Human) 840 post-translational protein acetylation [GO:0034421]; regulation of DNA replication [GO:0006275]; sister chromatid cohesion [GO:0007062] GO:0000785; GO:0005654; GO:0006275; GO:0007062; GO:0008080; GO:0034421; GO:0046872 0 0 0 PF13880;PF13878; Q5M9G3 CHOYP_LOC100565981.1.1 m.29912 sp CAPR1_RAT 36.198 384 218 9 20 382 52 429 1.77E-55 203 CAPR1_RAT reviewed Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105) Caprin1 Gpiap1 Rng105 Rattus norvegicus (Rat) 707 negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003] GO:0000932; GO:0003723; GO:0005829; GO:0010494; GO:0017148; GO:0030425; GO:0050775; GO:0061003 0 0 0 PF12287; Q5NVN8 CHOYP_RFOX3.1.1 m.2358 sp RFOX1_PONAB 57.333 75 28 2 94 165 83 156 1.77E-19 87 RFOX1_PONAB reviewed RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) RBFOX1 A2BP1 FOX1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 382 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0008380; GO:0043484 0 0 0 PF12414;PF00076; Q5RBZ2 CHOYP_MEP50.1.1 m.12931 sp MEP50_PONAB 38.941 321 176 5 5 322 24 327 1.77E-68 221 MEP50_PONAB reviewed Methylosome protein 50 (MEP-50) (WD repeat-containing protein 77) WDR77 MEP50 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 342 0 GO:0005634; GO:0005737; GO:0005829; GO:0008327; GO:0034709 0 0 0 PF00400; Q5TIA1 CHOYP_MEI1.1.1 m.45332 sp MEI1_HUMAN 25.686 510 333 8 55 533 89 583 1.77E-38 155 MEI1_HUMAN reviewed Meiosis inhibitor protein 1 (Meiosis defective protein 1) MEI1 Homo sapiens (Human) 1274 male meiosis I [GO:0007141]; meiosis I [GO:0007127]; meiotic telomere clustering [GO:0045141]; spermatid development [GO:0007286] GO:0005623; GO:0007127; GO:0007141; GO:0007286; GO:0045141 0 0 0 0 Q60841 CHOYP_RELN.4.4 m.61790 sp RELN_MOUSE 38.574 617 351 10 1 591 917 1531 1.77E-134 469 RELN_MOUSE reviewed Reelin (EC 3.4.21.-) (Reeler protein) Reln Rl Mus musculus (Mouse) 3461 "associative learning [GO:0008306]; axon guidance [GO:0007411]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell morphogenesis involved in differentiation [GO:0000904]; central nervous system development [GO:0007417]; cerebral cortex development [GO:0021987]; cerebral cortex tangential migration [GO:0021800]; dendrite development [GO:0016358]; forebrain development [GO:0030900]; glial cell differentiation [GO:0010001]; hippocampus development [GO:0021766]; lateral motor column neuron migration [GO:0097477]; layer formation in cerebral cortex [GO:0021819]; learning [GO:0007612]; long-term memory [GO:0007616]; long-term synaptic potentiation [GO:0060291]; modulation of synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; NMDA glutamate receptor clustering [GO:0097114]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000969]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of lateral motor column neuron migration [GO:1902078]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of TOR signaling [GO:0032008]; postsynaptic density assembly [GO:0097107]; postsynaptic density protein 95 clustering [GO:0097119]; protein localization to synapse [GO:0035418]; receptor localization to synapse [GO:0097120]; reelin-mediated signaling pathway [GO:0038026]; regulation of behavior [GO:0050795]; regulation of gene expression [GO:0010468]; regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310]; response to pain [GO:0048265]; spinal cord patterning [GO:0021511]; ventral spinal cord development [GO:0021517]" GO:0000904; GO:0001764; GO:0005578; GO:0005615; GO:0005737; GO:0005886; GO:0007155; GO:0007411; GO:0007417; GO:0007420; GO:0007612; GO:0007616; GO:0008236; GO:0008306; GO:0010001; GO:0010468; GO:0010976; GO:0014068; GO:0016358; GO:0016477; GO:0018108; GO:0021511; GO:0021517; GO:0021766; GO:0021800; GO:0021819; GO:0021987; GO:0030425; GO:0030900; GO:0032008; GO:0032793; GO:0035418; GO:0038026; GO:0045860; GO:0046872; GO:0048265; GO:0050731; GO:0050795; GO:0050804; GO:0051057; GO:0051968; GO:0060291; GO:0061003; GO:0061098; GO:0070325; GO:0070326; GO:0090129; GO:0097107; GO:0097114; GO:0097119; GO:0097120; GO:0097477; GO:1900273; GO:1902078; GO:2000310; GO:2000463; GO:2000969 0 0 cd08544; PF02014; Q6AY22 CHOYP_LOC100374267.4.5 m.44162 sp SPAT1_RAT 37.745 204 119 5 85 287 248 444 1.77E-29 119 SPAT1_RAT reviewed Spermatogenesis-associated protein 1 Spata1 Rattus norvegicus (Rat) 444 0 0 0 0 0 PF15743; Q6DIB5 CHOYP_PEAR1.9.16 m.42307 sp MEG10_MOUSE 34.553 246 135 11 52 285 431 662 1.77E-26 115 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6NYE7 CHOYP_BRAFLDRAFT_122979.1.1 m.15513 sp TM192_DANRE 35.326 184 113 4 86 265 87 268 1.77E-25 104 TM192_DANRE reviewed Transmembrane protein 192 tmem192 zgc:77068 Danio rerio (Zebrafish) (Brachydanio rerio) 271 0 GO:0005765; GO:0005770; GO:0016021 0 0 0 PF14802; Q6QLW4 CHOYP_CYC.1.5 m.5663 sp CYC_PECGU 84.404 109 17 0 15 123 1 109 1.77E-65 196 CYC_PECGU reviewed Cytochrome c 0 Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm) 109 oxidation-reduction process [GO:0055114] GO:0005758; GO:0009055; GO:0020037; GO:0046872; GO:0055114; GO:0070469 0 0 0 PF00034; Q711G3 CHOYP_LOC100726448.1.1 m.26536 sp IAH1_RAT 48.214 224 110 5 11 230 14 235 1.77E-66 209 IAH1_RAT reviewed Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-) (Hypertrophic agonist-responsive protein B64) Iah1 Harpb64 Rattus norvegicus (Rat) 249 lipid catabolic process [GO:0016042] GO:0016042; GO:0016787; GO:0070062 0 0 0 PF13472; Q7TNF8 CHOYP_BZRAP1.1.2 m.39094 sp RIMB1_MOUSE 31.843 1096 603 29 78 1123 70 1071 1.77E-132 449 RIMB1_MOUSE reviewed Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) Tspoap1 Bzrap1 Kiaa0612 Rbp1 Mus musculus (Mouse) 1846 0 GO:0005737; GO:0005739; GO:0030156 0 0 0 PF07653;PF14604; Q86UA1 CHOYP_BRAFLDRAFT_117858.3.3 m.61650 sp PRP39_HUMAN 54.684 459 188 5 36 488 80 524 1.77E-174 509 PRP39_HUMAN reviewed Pre-mRNA-processing factor 39 (PRP39 homolog) PRPF39 Homo sapiens (Human) 669 mRNA 5'-splice site recognition [GO:0000395] GO:0000243; GO:0000395; GO:0005685; GO:0071004 0 0 0 0 Q8BKZ9 CHOYP_ODPX.1.1 m.29097 sp ODPX_MOUSE 46.507 458 221 10 55 489 44 500 1.77E-130 390 ODPX_MOUSE reviewed "Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X)" Pdhx Mus musculus (Mouse) 501 mitochondrial acetyl-CoA biosynthetic process from pyruvate [GO:0061732] GO:0005739; GO:0005759; GO:0016746; GO:0034604; GO:0045254; GO:0061732 0 0 0 PF00198;PF00364;PF02817; Q8K0U4 CHOYP_BRAFLDRAFT_208293.7.20 m.39150 sp HS12A_MOUSE 38.532 109 63 1 18 122 414 522 1.77E-18 83.2 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q92193 CHOYP_ACT5.1.3 m.30369 sp ACT_CRAVI 95.455 154 7 0 1 154 36 189 1.77E-105 305 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q967D7 CHOYP_LOC583206.1.1 m.63834 sp TUTL_DROME 33.333 249 150 7 1 240 603 844 1.77E-34 136 TUTL_DROME reviewed Protein turtle tutl CG15427 Drosophila melanogaster (Fruit fly) 1531 adult locomotory behavior [GO:0008344]; axonal defasciculation [GO:0007414]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite self-avoidance [GO:0070593]; flight behavior [GO:0007629]; larval behavior [GO:0030537]; lateral inhibition [GO:0046331]; mechanosensory behavior [GO:0007638]; R7 cell development [GO:0045467]; regulation of dendrite morphogenesis [GO:0048814]; sensory perception of pain [GO:0019233]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007411; GO:0007414; GO:0007629; GO:0007638; GO:0008039; GO:0008344; GO:0016199; GO:0019233; GO:0030537; GO:0045467; GO:0046331; GO:0048814; GO:0070593; GO:0098632 0 0 0 PF00041;PF07679;PF07686; Q96MM6 CHOYP_BRAFLDRAFT_208293.10.20 m.53518 sp HS12B_HUMAN 28.662 471 270 14 1070 1478 47 513 1.77E-44 176 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99828 CHOYP_BRAFLDRAFT_125227.1.2 m.7366 sp CIB1_HUMAN 46.032 189 95 3 1 182 1 189 1.77E-54 174 CIB1_HUMAN reviewed Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28) CIB1 CIB KIP PRKDCIP Homo sapiens (Human) 191 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to growth factor stimulus [GO:0071363]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic microtubule organization [GO:0031122]; double-strand break repair [GO:0006302]; endomitotic cell cycle [GO:0007113]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; platelet formation [GO:0030220]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell growth [GO:0030307]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of cell division [GO:0051302]; regulation of cell proliferation [GO:0042127]; response to ischemia [GO:0002931]; spermatid development [GO:0007286]; thrombopoietin-mediated signaling pathway [GO:0038163] GO:0001525; GO:0001933; GO:0001934; GO:0001954; GO:0002931; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005794; GO:0005813; GO:0005886; GO:0006302; GO:0006915; GO:0006974; GO:0007026; GO:0007113; GO:0007155; GO:0007286; GO:0008284; GO:0008285; GO:0008427; GO:0010977; GO:0016020; GO:0016324; GO:0017016; GO:0030027; GO:0030220; GO:0030291; GO:0030307; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031122; GO:0031982; GO:0032433; GO:0032587; GO:0033630; GO:0038163; GO:0042127; GO:0042383; GO:0043005; GO:0043025; GO:0043066; GO:0043085; GO:0043495; GO:0045653; GO:0048471; GO:0051092; GO:0051301; GO:0051302; GO:0051898; GO:0070062; GO:0070374; GO:0070886; GO:0071356; GO:0071363; GO:0071902; GO:0071944; GO:0090004; GO:0090050; GO:0090314; GO:0097191; GO:1900026; GO:1990090; GO:2000256 0 0 0 PF13499; Q99JY8 CHOYP_LPP3.2.2 m.60456 sp PLPP3_MOUSE 45.847 301 131 6 3 299 20 292 1.77E-72 232 PLPP3_MOUSE reviewed Phospholipid phosphatase 3 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) Plpp3 Lpp3 Ppap2b Mus musculus (Mouse) 312 Bergmann glial cell differentiation [GO:0060020]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion [GO:0044329]; canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration [GO:0044328]; canonical Wnt signaling pathway involved in positive regulation of wound healing [GO:0044330]; cell adhesion [GO:0007155]; gastrulation with mouth forming second [GO:0001702]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of protein phosphorylation [GO:0001933]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein stabilization [GO:0050821]; regulation of sphingolipid mediated signaling pathway [GO:1902068]; regulation of Wnt signaling pathway [GO:0030111]; single organismal cell-cell adhesion [GO:0016337] GO:0001568; GO:0001702; GO:0001933; GO:0005178; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0006644; GO:0007155; GO:0008195; GO:0016337; GO:0030111; GO:0034109; GO:0042392; GO:0042577; GO:0044328; GO:0044329; GO:0044330; GO:0046839; GO:0050731; GO:0050821; GO:0051091; GO:0060020; GO:0060070; GO:0070062; GO:1902068 0 0 0 PF01569; Q9BDK2 CHOYP_BRAFLDRAFT_81509.1.1 m.31565 sp AIF1_BOVIN 50 142 71 0 7 148 6 147 1.77E-42 140 AIF1_BOVIN reviewed Allograft inflammatory factor 1 (AIF-1) AIF1 Bos taurus (Bovine) 147 "actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; cellular response to interferon-gamma [GO:0071346]; inflammatory response [GO:0006954]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell proliferation [GO:0048662]; phagocytosis, engulfment [GO:0006911]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; Rac protein signal transduction [GO:0016601]; ruffle assembly [GO:0097178]" GO:0001891; GO:0005509; GO:0005634; GO:0005737; GO:0005829; GO:0005884; GO:0006911; GO:0006954; GO:0016601; GO:0030027; GO:0030041; GO:0032587; GO:0042102; GO:0048471; GO:0048661; GO:0048662; GO:0051015; GO:0051017; GO:0071346; GO:0071672; GO:0071673; GO:0090026; GO:0097178; GO:1900087; GO:2000406 0 0 0 0 Q9DBS2 CHOYP_MYS.1.7 m.435 sp TPRGL_MOUSE 31.022 274 176 6 25 294 2 266 1.77E-44 155 TPRGL_MOUSE reviewed Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) Tprg1l Fam79a Mover Tprgl Mus musculus (Mouse) 266 0 GO:0008021; GO:0030054; GO:0042802; GO:0070062 0 0 0 PF12456; Q9H9H4 CHOYP_LOC100872239.1.1 m.53052 sp VP37B_HUMAN 35.484 186 115 3 28 211 17 199 1.77E-29 114 VP37B_HUMAN reviewed Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) VPS37B Homo sapiens (Human) 285 autophagy [GO:0006914]; endosomal transport [GO:0016197]; intracellular transport of virus [GO:0075733]; multivesicular body assembly [GO:0036258]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral release from host cell [GO:1902188]; protein transport [GO:0015031]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058] GO:0000813; GO:0005737; GO:0005768; GO:0005886; GO:0006914; GO:0010008; GO:0015031; GO:0016197; GO:0019058; GO:0030496; GO:0031902; GO:0036258; GO:0039702; GO:0048306; GO:0070062; GO:0075733; GO:1902188; GO:1903774 0 0 0 PF07200; Q9VEX9 CHOYP_LOC100313731.1.1 m.9930 sp SAP18_DROME 62.667 150 55 1 1 150 1 149 1.77E-65 199 SAP18_DROME reviewed Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (Bicoid-interacting protein 1) (dSAP18) Bin1 SAP18 CG6046 Drosophila melanogaster (Fruit fly) 150 "chromatin silencing [GO:0006342]; mRNA splicing, via spliceosome [GO:0000398]; multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0000398; GO:0003714; GO:0005737; GO:0006342; GO:0006351; GO:0007275; GO:0008134; GO:0016580; GO:0045892; GO:0071011; GO:0071013 0 0 0 PF06487; Q9VVR0 CHOYP_LOAG_09404.1.1 m.7582 sp Y3380_DROME 44.681 47 26 0 41 87 94 140 1.77E-06 47 Y3380_DROME reviewed Uncharacterized protein CG13380 CG13380 Drosophila melanogaster (Fruit fly) 169 0 0 0 0 0 0 Q9VXK6 CHOYP_LOC100371557.1.1 m.57537 sp IF5_DROME 53.301 409 177 5 1 396 1 408 1.77E-151 441 IF5_DROME reviewed Eukaryotic translation initiation factor 5 (eIF-5) eIF5 CG9177 Drosophila melanogaster (Fruit fly) 464 neurogenesis [GO:0022008]; translational initiation [GO:0006413] GO:0003743; GO:0005525; GO:0005829; GO:0006413; GO:0022008 0 0 0 PF01873;PF02020; Q9W704 CHOYP_NEMVEDRAFT_V1G174335.1.1 m.31326 sp RIPA_XENLA 37.5 216 122 6 59 267 7 216 1.77E-38 137 RIPA_XENLA reviewed RPA-interacting protein A (RPA-interacting protein alpha) (XRIPalpha) rpain-a rip-a Xenopus laevis (African clawed frog) 226 0 GO:0005634; GO:0046872 0 0 0 PF14768;PF14767;PF14766; Q9XWB9 CHOYP_LOC101236379.2.2 m.34893 sp BAT36_CAEEL 31.683 101 67 2 30 129 157 256 1.77E-07 55.1 BAT36_CAEEL reviewed BTB and MATH domain-containing protein 36 bath-36 Y75B12B.4 Caenorhabditis elegans 320 0 0 0 0 0 PF00651;PF00917; Q9Y345 CHOYP_SC6A5.5.7 m.49357 sp SC6A5_HUMAN 49.096 332 138 3 38 359 173 483 1.77E-98 311 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Y383 CHOYP_LOC100648220.1.1 m.26262 sp LC7L2_HUMAN 70.293 239 71 0 1 239 1 239 1.77E-124 367 LC7L2_HUMAN reviewed Putative RNA-binding protein Luc7-like 2 LUC7L2 CGI-59 CGI-74 Homo sapiens (Human) 392 mRNA splice site selection [GO:0006376] GO:0003729; GO:0005685; GO:0006376; GO:0016607; GO:0019899; GO:0044822; GO:0071004 0 0 0 PF03194; Q9Y5B6 CHOYP_LOC100182291.1.1 m.44669 sp PAXB1_HUMAN 31.356 118 68 3 6 111 458 574 1.77E-08 55.1 PAXB1_HUMAN reviewed PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) PAXBP1 C21orf66 GCFC GCFC1 Homo sapiens (Human) 917 "muscle organ development [GO:0007517]; positive regulation of histone methylation [GO:0031062]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003700; GO:0005634; GO:0005829; GO:0006351; GO:0007517; GO:0014842; GO:0031062; GO:0045944; GO:2000288 0 0 0 PF07842; Q9YGL3 CHOYP_NR2E1.1.1 m.4497 sp NR2E1_ORYLA 52.267 375 158 7 9 374 20 382 1.77E-134 392 NR2E1_ORYLA reviewed Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) nr2e1 tll tlx Oryzias latipes (Japanese rice fish) (Japanese killifish) 396 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0007275; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; D2GXS7 CHOYP_BRAFLDRAFT_87279.7.10 m.42014 sp TRIM2_AILME 23.684 152 115 1 316 467 593 743 1.78E-07 57.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_TRIM2.3.59 m.3770 sp TRIM2_AILME 26.887 212 138 6 20 226 545 744 1.78E-11 66.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D4AR77 CHOYP_LOC100893261.3.3 m.55089 sp A6907_ARTBC 25.795 283 171 10 89 358 363 619 1.78E-14 79 A6907_ARTBC reviewed Uncharacterized secreted protein ARB_06907 ARB_06907 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) 930 0 GO:0005576; GO:0008236 0 0 0 PF00326; H2A0K6 CHOYP_VRP.3.4 m.19819 sp VRP_PINMG 44.186 215 114 3 3 213 25 237 1.78E-34 125 VRP_PINMG reviewed Valine-rich protein (Alveoline-like protein) 0 Pinctada margaritifera (Black-lipped pearl oyster) 238 0 GO:0005576 0 0 0 0 H2LRU7 CHOYP_LOC100207545.1.1 m.62062 sp PKD2_ORYLA 23.506 251 171 5 24 267 500 736 1.78E-16 83.2 PKD2_ORYLA reviewed Polycystin-2 (Polycystic kidney disease 2 protein homolog) pkd2 Oryzias latipes (Japanese rice fish) (Japanese killifish) 901 detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; ion transport [GO:0006811] GO:0003127; GO:0005509; GO:0005783; GO:0005929; GO:0006811; GO:0016021; GO:0050982; GO:0060170 0 0 0 PF08016; O01393 CHOYP_AAEL_AAEL004138.1.2 m.7302 sp UNC9_CAEEL 34.959 369 233 2 14 382 21 382 1.78E-85 268 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O14965 CHOYP_AURKA.1.1 m.15508 sp AURKA_HUMAN 68.35 297 92 2 30 326 109 403 1.78E-155 444 AURKA_HUMAN reviewed Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (hARK1) (Breast tumor-amplified kinase) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase aurora-A) AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6 Homo sapiens (Human) 403 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; anterior/posterior axis specification [GO:0009948]; cell division [GO:0051301]; centrosome localization [GO:0051642]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G2/M transition of mitotic cell cycle [GO:0000086]; meiotic spindle organization [GO:0000212]; mitotic centrosome separation [GO:0007100]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein binding [GO:0032091]; neuron projection extension [GO:1990138]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of oocyte maturation [GO:1900195]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein autophosphorylation [GO:0046777]; protein localization to centrosome [GO:0071539]; protein phosphorylation [GO:0006468]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of centrosome cycle [GO:0046605]; regulation of cytokinesis [GO:0032465]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to estradiol [GO:0032355]; spindle assembly involved in female meiosis I [GO:0007057]; spindle organization [GO:0007051]" GO:0000086; GO:0000212; GO:0000780; GO:0004672; GO:0004674; GO:0004712; GO:0005524; GO:0005634; GO:0005654; GO:0005813; GO:0005814; GO:0005819; GO:0005829; GO:0005874; GO:0005929; GO:0006468; GO:0006977; GO:0007051; GO:0007052; GO:0007057; GO:0007067; GO:0007100; GO:0009948; GO:0015630; GO:0019901; GO:0030496; GO:0031145; GO:0031616; GO:0031647; GO:0032091; GO:0032133; GO:0032355; GO:0032436; GO:0032465; GO:0035174; GO:0042585; GO:0042787; GO:0043066; GO:0043203; GO:0045120; GO:0045840; GO:0046605; GO:0046777; GO:0048471; GO:0051233; GO:0051301; GO:0051642; GO:0071539; GO:0072686; GO:0072687; GO:1900195; GO:1901796; GO:1990138 0 0 0 PF00069; O75123 CHOYP_ZN436.1.3 m.3520 sp ZN623_HUMAN 39.623 318 183 4 155 471 145 454 1.78E-72 241 ZN623_HUMAN reviewed Zinc finger protein 623 ZNF623 KIAA0628 Homo sapiens (Human) 536 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; O75330 CHOYP_HMMR.1.1 m.16310 sp HMMR_HUMAN 50.355 141 68 2 1211 1350 572 711 1.78E-30 133 HMMR_HUMAN reviewed Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) HMMR IHABP RHAMM Homo sapiens (Human) 724 G2/M transition of mitotic cell cycle [GO:0000086]; hyaluronan catabolic process [GO:0030214] GO:0000086; GO:0005540; GO:0005829; GO:0005886; GO:0009986; GO:0016020; GO:0030214 0 0 0 PF15908;PF15905; P02434 CHOYP_BRAFLDRAFT_277091.1.3 m.1103 sp RL35A_XENLA 72.477 109 29 1 25 133 3 110 1.78E-52 164 RL35A_XENLA reviewed 60S ribosomal protein L35a (L32) rpl35a Xenopus laevis (African clawed frog) 110 translation [GO:0006412] GO:0000049; GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01247; P06603 CHOYP_TBA1.4.9 m.14942 sp TBA1_DROME 96.842 190 1 1 2 191 45 229 1.78E-129 375 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P0C8E4 CHOYP_M3K7.4.4 m.19672 sp M3K7_RAT 58.482 448 145 10 11 446 29 447 1.78E-174 510 M3K7_RAT reviewed Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) Map3k7 Rattus norvegicus (Rat) 606 "activation of MAPKK activity [GO:0000186]; apoptotic process [GO:0006915]; I-kappaB phosphorylation [GO:0007252]; MAPK cascade [GO:0000165]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JUN kinase activity [GO:0043507]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000165; GO:0000186; GO:0000287; GO:0004709; GO:0005524; GO:0005622; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0007252; GO:0043123; GO:0043507 0 0 0 PF07714; P13993 CHOYP_PY01794.1.1 m.10119 sp PRP2_SOYBN 28.431 102 68 2 392 493 99 195 1.78E-07 56.6 PRP2_SOYBN reviewed Repetitive proline-rich cell wall protein 2 PRP2 RPRP3 Glycine max (Soybean) (Glycine hispida) 230 multicellular organism development [GO:0007275] GO:0005199; GO:0005576; GO:0005618; GO:0007275 0 0 0 PF02095; P15253 CHOYP_S39AA.3.3 m.64561 sp CALR_RABIT 70.33 91 27 0 7 97 276 366 1.78E-42 148 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P21761 CHOYP_TRFR.3.3 m.66098 sp TRFR_MOUSE 42.105 342 172 6 1 320 1 338 1.78E-86 268 TRFR_MOUSE reviewed Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) Trhr Mus musculus (Mouse) 393 0 GO:0004997; GO:0005886; GO:0016021 0 0 0 PF00001; P28026 CHOYP_WNT8B.2.2 m.62067 sp WNT8_XENLA 43.611 360 175 6 1 353 1 339 1.78E-100 303 WNT8_XENLA reviewed Protein Wnt-8 (XWnt-8) wnt8 Xenopus laevis (African clawed frog) 358 canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; embryonic axis specification [GO:0000578]; negative regulation of cardiac cell fate specification [GO:2000044]; neural crest cell fate commitment [GO:0014034]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; regulation of transcription involved in anterior/posterior axis specification [GO:0044324]; Spemann organizer formation [GO:0060061]; Wnt signaling pathway [GO:0016055] GO:0000578; GO:0002020; GO:0005109; GO:0005576; GO:0005578; GO:0014034; GO:0016055; GO:0044324; GO:0044335; GO:0051091; GO:0060061; GO:0060070; GO:2000044 0 0 0 PF00110; P35408 CHOYP_BRAFLDRAFT_126346.2.2 m.56720 sp PE2R4_HUMAN 33.528 343 191 7 64 376 21 356 1.78E-62 215 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P45447 CHOYP_E75.2.3 m.59097 sp E78C_DROME 51.765 85 41 0 10 94 360 444 1.78E-23 110 E78C_DROME reviewed Ecdysone-induced protein 78C (DR-78) (Nuclear receptor subfamily 1 group E member 1) Eip78C NR1E1 CG18023 Drosophila melanogaster (Fruit fly) 862 "negative regulation of transcription, DNA-templated [GO:0045892]; regulation of glucose metabolic process [GO:0010906]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0010906; GO:0043565; GO:0045892 0 0 0 PF00104;PF00105; P50882 CHOYP_RL9.1.6 m.5941 sp RL9_DROME 76.147 109 25 1 1 108 78 186 1.78E-54 171 RL9_DROME reviewed 60S ribosomal protein L9 RpL9 M(2)32D CG6141 Drosophila melanogaster (Fruit fly) 190 centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052] GO:0000022; GO:0002181; GO:0003723; GO:0003735; GO:0005840; GO:0007052; GO:0019843; GO:0022625; GO:0051298 0 0 0 PF00347; P86789 CHOYP_LOC100375482.1.2 m.3324 sp GIGA6_CRAGI 33.074 257 166 6 27 278 25 280 1.78E-34 135 GIGA6_CRAGI reviewed Gigasin-6 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 302 0 GO:0016021 0 0 0 PF00144; P87061 CHOYP_BRAFLDRAFT_89663.1.2 m.35227 sp TEA1_SCHPO 27.599 279 182 11 45 310 78 349 1.78E-19 97.4 TEA1_SCHPO reviewed Tip elongation aberrant protein 1 (Altered polarity protein 8) (Cell polarity protein tea1) tea1 alp8 SPCC1223.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1147 cellular protein localization [GO:0034613]; establishment or maintenance of bipolar cell polarity regulating cell shape [GO:0061246]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; positive regulation of establishment or maintenance of cell polarity regulating cell shape [GO:2000771]; regulation of filamentous growth [GO:0010570] GO:0005874; GO:0010570; GO:0015630; GO:0031500; GO:0032153; GO:0034613; GO:0035838; GO:0035839; GO:0035840; GO:0051285; GO:0051286; GO:0061246; GO:0071963; GO:2000771 0 0 0 PF01344;PF07646; Q01617 CHOYP_LOC100121425.1.1 m.10532 sp CPO_DROME 68.617 188 46 7 17 196 423 605 1.78E-68 229 CPO_DROME reviewed Protein couch potato cpo CG43738 Drosophila melanogaster (Fruit fly) 606 chemical synaptic transmission [GO:0007268]; dormancy process [GO:0022611]; multicellular organism development [GO:0007275]; olfactory behavior [GO:0042048]; regulation of hemocyte proliferation [GO:0035206] GO:0000166; GO:0003729; GO:0005634; GO:0007268; GO:0007275; GO:0022611; GO:0035206; GO:0042048 0 0 0 PF00076; Q06AA5 CHOYP_TSN4.1.1 m.9304 sp TSN9_PIG 35.714 238 143 5 10 245 6 235 1.78E-45 155 TSN9_PIG reviewed Tetraspanin-9 (Tspan-9) TSPAN9 Sus scrofa (Pig) 239 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0005925; GO:0007166; GO:0097197 0 0 0 PF00335; Q16514 CHOYP_TAF12.1.1 m.7469 sp TAF12_HUMAN 72.131 122 28 1 39 154 40 161 1.78E-60 187 TAF12_HUMAN reviewed Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15) TAF12 TAF15 TAF2J TAFII20 Homo sapiens (Human) 161 "DNA-templated transcription, initiation [GO:0006352]; histone H3 acetylation [GO:0043966]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000125; GO:0003677; GO:0003713; GO:0005654; GO:0005669; GO:0006352; GO:0006366; GO:0006367; GO:0006368; GO:0008134; GO:0030914; GO:0033276; GO:0043966; GO:0051091; GO:1901796 0 0 cd07981; PF03847; Q27294 CHOYP_LOC100744767.2.2 m.66426 sp CAZ_DROME 55.319 94 42 0 32 125 114 207 1.78E-29 112 CAZ_DROME reviewed RNA-binding protein cabeza (P19) (Sarcoma-associated RNA-binding fly homolog) caz SARFH CG3606 Drosophila melanogaster (Fruit fly) 399 "adult locomotory behavior [GO:0008344]; compound eye development [GO:0048749]; larval locomotory behavior [GO:0008345]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; synaptic growth at neuromuscular junction [GO:0051124]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000166; GO:0000398; GO:0003729; GO:0005634; GO:0005654; GO:0005669; GO:0006367; GO:0008270; GO:0008344; GO:0008345; GO:0045887; GO:0048749; GO:0051124; GO:0071013 0 0 0 PF00076;PF00641; Q32L77 CHOYP_LOC580840.1.1 m.45392 sp CI135_BOVIN 39.72 214 123 5 3 214 22 231 1.78E-42 145 CI135_BOVIN reviewed Uncharacterized protein C9orf135 homolog 0 Bos taurus (Bovine) 232 0 GO:0016021 0 0 0 PF15139; Q502M6 CHOYP_ANR29.2.2 m.54147 sp ANR29_DANRE 35.976 164 87 2 1 164 55 200 1.78E-24 99.4 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q54RV9 CHOYP_LOC100370334.1.1 m.48934 sp SGPL_DICDI 39.087 504 273 7 30 530 41 513 1.78E-117 360 SGPL_DICDI reviewed Sphingosine-1-phosphate lyase (S1P lyase) (S1PL) (SP-lyase) (SPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase) sglA DDB_G0282819 Dictyostelium discoideum (Slime mold) 528 actin cytoskeleton organization [GO:0030036]; ameboidal-type cell migration [GO:0001667]; carboxylic acid metabolic process [GO:0019752]; cell death [GO:0008219]; cell motility [GO:0048870]; cellular calcium ion homeostasis [GO:0006874]; ceramide metabolic process [GO:0006672]; chemotaxis [GO:0006935]; locomotion [GO:0040011]; negative regulation of aggregate size involved in sorocarp development [GO:0031158]; negative regulation of lateral pseudopodium assembly [GO:0031276]; positive phototaxis [GO:0046956]; regulation of actin filament polymerization [GO:0030833]; sorocarp development [GO:0030587]; sphingolipid catabolic process [GO:0030149]; sporulation resulting in formation of a cellular spore [GO:0030435] GO:0001667; GO:0005789; GO:0006672; GO:0006874; GO:0006935; GO:0008117; GO:0008219; GO:0016021; GO:0016831; GO:0019752; GO:0030036; GO:0030149; GO:0030170; GO:0030435; GO:0030587; GO:0030833; GO:0031158; GO:0031276; GO:0040011; GO:0046956; GO:0048870 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00282; Q5EB28 CHOYP_MIDN.3.3 m.56781 sp MIDN_XENTR 35.309 388 189 11 9 334 20 407 1.78E-53 186 MIDN_XENTR reviewed Midnolin (Midbrain nucleolar protein) midn TNeu058f14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 453 0 GO:0005730 0 0 0 PF00240; Q5FVR5 CHOYP_BRAFLDRAFT_72274.2.2 m.51333 sp ACNT2_RAT 39.423 416 238 8 33 440 2 411 1.78E-91 286 ACNT2_RAT reviewed Acyl-coenzyme A amino acid N-acyltransferase 2 (EC 2.3.1.-) Acnat2 Rattus norvegicus (Rat) 418 acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] GO:0005777; GO:0006631; GO:0006637; GO:0016410; GO:0016790 0 0 0 PF08840;PF04775; Q5ND28 CHOYP_MEGF6.5.59 m.4448 sp SREC_MOUSE 36.81 163 97 5 194 354 215 373 1.78E-22 103 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5R941 CHOYP_LOC659512.1.4 m.6122 sp FKB14_PONAB 45.32 203 100 7 16 213 9 205 1.78E-46 155 FKB14_PONAB reviewed Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase) FKBP14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 211 protein folding [GO:0006457] GO:0003755; GO:0005509; GO:0005788; GO:0006457 0 0 0 PF13499;PF00254; Q61SK8 CHOYP_PHUM_PHUM538050.1.1 m.56205 sp MEP1_CAEBR 28.488 172 102 3 561 726 371 527 1.78E-08 62.8 MEP1_CAEBR reviewed MOG interacting and ectopic P-granules protein 1 (Nuclear zinc finger protein) mep-1 CBG06138 Caenorhabditis briggsae 880 cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; hermaphrodite genitalia development [GO:0040035]; nematode larval development [GO:0002119] GO:0002119; GO:0003723; GO:0005634; GO:0007506; GO:0008134; GO:0017151; GO:0030154; GO:0040035; GO:0042826; GO:0046872 0 0 0 0 Q6J1I7 CHOYP_LOC100376527.1.1 m.54882 sp RN166_RAT 41.379 232 124 4 10 237 13 236 1.78E-61 195 RN166_RAT reviewed RING finger protein 166 Rnf166 Rattus norvegicus (Rat) 237 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0005622; GO:0008270; GO:0031624; GO:0032436; GO:0061630 0 0 0 PF05605; Q6Q899 CHOYP_DDX58.1.9 m.822 sp DDX58_MOUSE 30.79 734 452 23 403 1108 212 917 1.78E-82 292 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6UWZ7 CHOYP_ISCW_ISCW009320.1.1 m.13803 sp F175A_HUMAN 28.521 284 171 10 2 274 7 269 1.78E-25 112 F175A_HUMAN reviewed BRCA1-A complex subunit Abraxas (Coiled-coil domain-containing protein 98) (Protein FAM175A) FAM175A ABRA1 CCDC98 UNQ496/PRO1013 Homo sapiens (Human) 409 covalent chromatin modification [GO:0016569]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; G2 DNA damage checkpoint [GO:0031572]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212] GO:0005634; GO:0005654; GO:0006302; GO:0006303; GO:0010212; GO:0016569; GO:0031572; GO:0031593; GO:0045739; GO:0070531 0 0 0 0 Q78S06 CHOYP_LOC100710299.1.1 m.7377 sp SYS1_MOUSE 46.622 148 79 0 13 160 2 149 1.78E-47 154 SYS1_MOUSE reviewed Protein SYS1 homolog Sys1 Mus musculus (Mouse) 156 Golgi to endosome transport [GO:0006895]; Golgi to plasma membrane protein transport [GO:0043001]; protein targeting to Golgi [GO:0000042] GO:0000042; GO:0005802; GO:0005829; GO:0006895; GO:0030173; GO:0043001 0 0 0 PF09801; Q7TPQ9 CHOYP_BRAFLDRAFT_199194.1.1 m.51866 sp ARRD3_MOUSE 25.823 395 240 17 2 378 5 364 1.78E-26 113 ARRD3_MOUSE reviewed Arrestin domain-containing protein 3 Arrdc3 Kiaa1376 Mus musculus (Mouse) 414 fat pad development [GO:0060613]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of multicellular organismal metabolic process [GO:0044252]; positive regulation of adrenergic receptor signaling pathway [GO:0071879]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; skin development [GO:0043588]; temperature homeostasis [GO:0001659] GO:0001659; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0031651; GO:0031699; GO:0043588; GO:0044252; GO:0051443; GO:0060613; GO:0071879; GO:0090327 0 0 0 PF02752;PF00339; Q80TY5 CHOYP_LOC100371084.1.4 m.18252 sp VP13B_MOUSE 38.796 781 422 15 1 738 43 810 1.78E-151 492 VP13B_MOUSE reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) 4013 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q80TY5 CHOYP_LOC100371084.4.4 m.43984 sp VP13B_MOUSE 46.429 448 206 8 4 419 2 447 1.78E-114 372 VP13B_MOUSE reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) 4013 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q80YG3 CHOYP_KLDC1.2.2 m.56044 sp KLDC1_MOUSE 39.846 389 206 10 29 405 4 376 1.78E-86 273 KLDC1_MOUSE reviewed Kelch domain-containing protein 1 Klhdc1 Mus musculus (Mouse) 406 0 GO:0005737 0 0 0 PF07646; Q8HYR6 CHOYP_DHRS9.1.1 m.57974 sp DHRS9_BOVIN 41.379 87 46 3 18 100 16 101 1.78E-12 65.5 DHRS9_BOVIN reviewed Dehydrogenase/reductase SDR family member 9 (EC 1.1.-.-) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (Short-chain dehydrogenase/reductase retSDR8) DHRS9 Bos taurus (Bovine) 319 9-cis-retinoic acid biosynthetic process [GO:0042904] GO:0004022; GO:0004745; GO:0030176; GO:0031090; GO:0042904; GO:0047035 0 0 0 PF00106; Q8N2E2 CHOYP_BRAFLDRAFT_215789.1.1 m.60401 sp VWDE_HUMAN 21.928 529 322 19 13 465 530 1043 1.78E-14 81.3 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N2E2 CHOYP_BRAFLDRAFT_80496.4.10 m.22918 sp VWDE_HUMAN 22.867 293 210 5 507 786 800 1089 1.78E-13 79 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TF62 CHOYP_ATP8B2.3.3 m.66859 sp AT8B4_HUMAN 67.188 64 20 1 6 68 4 67 1.78E-20 88.6 AT8B4_HUMAN reviewed Probable phospholipid-transporting ATPase IM (EC 3.6.3.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4) ATP8B4 KIAA1939 Homo sapiens (Human) 1192 Golgi organization [GO:0007030] GO:0000287; GO:0004012; GO:0005524; GO:0005794; GO:0005886; GO:0007030; GO:0016021 0 0 0 PF00122;PF16212;PF16209; Q90705 CHOYP_EF2.1.5 m.1543 sp EF2_CHICK 77.07 157 36 0 7 163 702 858 1.78E-84 268 EF2_CHICK reviewed Elongation factor 2 (EF-2) EEF2 Gallus gallus (Chicken) 858 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; Q92982 CHOYP_LOC100123713.3.3 m.61909 sp NINJ1_HUMAN 27.632 76 55 0 85 160 39 114 1.78E-06 49.7 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q96AJ9 CHOYP_LOC592006.1.1 m.18498 sp VTI1A_HUMAN 49.537 216 108 1 30 244 1 216 1.78E-70 218 VTI1A_HUMAN reviewed Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2) VTI1A Homo sapiens (Human) 217 "autophagy [GO:0006914]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi ribbon formation [GO:0090161]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein targeting to vacuole [GO:0006623]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882]" GO:0000139; GO:0000149; GO:0005484; GO:0005768; GO:0005776; GO:0005789; GO:0005794; GO:0005829; GO:0006623; GO:0006888; GO:0006891; GO:0006896; GO:0006914; GO:0008021; GO:0012507; GO:0016021; GO:0030136; GO:0031201; GO:0031902; GO:0032588; GO:0042147; GO:0043025; GO:0044306; GO:0048280; GO:0048471; GO:0050882; GO:0090161 0 0 0 PF05008; Q98SW2 CHOYP_LOC101067536.1.1 m.63102 sp HIF1A_ONCMY 40.708 565 273 14 7 516 12 569 1.78E-122 385 HIF1A_ONCMY reviewed Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) hif1a Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 766 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005623; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016607 0 0 0 PF11413;PF08778;PF08447;PF13426; Q9BYR4 CHOYP_LOC100211659.1.1 m.21460 sp KRA43_HUMAN 32 125 82 2 8 131 42 164 1.78E-13 71.6 KRA43_HUMAN reviewed Keratin-associated protein 4-3 (Keratin-associated protein 4.3) (Ultrahigh sulfur keratin-associated protein 4.3) KRTAP4-3 KAP4.3 KRTAP4.3 Homo sapiens (Human) 195 aging [GO:0007568]; hair cycle [GO:0042633] GO:0007568; GO:0042633; GO:0045095 0 0 0 PF13885; Q9D4P0 CHOYP_BRAFLDRAFT_284242.1.1 m.13711 sp ARL5B_MOUSE 81.006 179 34 0 1 179 1 179 1.78E-109 312 ARL5B_MOUSE reviewed ADP-ribosylation factor-like protein 5B (ADP-ribosylation factor-like protein 8) Arl5b Arl8 Mus musculus (Mouse) 179 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF00025; Q9HCF6 CHOYP_TRPM8.1.5 m.5216 sp TRPM3_HUMAN 26.625 323 207 8 90 405 889 1188 1.78E-30 129 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9NFP5 CHOYP_DSIM_GD13062.1.1 m.3175 sp SH3BG_DROME 45.283 106 50 2 1 99 1 105 1.78E-25 96.7 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9QZK7 CHOYP_BRAFLDRAFT_88218.4.8 m.24868 sp DOK3_MOUSE 35.484 93 57 2 550 642 150 239 1.78E-09 63.9 DOK3_MOUSE reviewed Docking protein 3 (Downstream of tyrosine kinase 3) (p62(dok)-like protein) (DOK-L) Dok3 Dokl Mus musculus (Mouse) 444 Ras protein signal transduction [GO:0007265] GO:0005737; GO:0005886; GO:0007265 0 0 0 PF02174; Q9UPN3 CHOYP_BRAFLDRAFT_123699.1.1 m.1714 sp MACF1_HUMAN 49.419 172 80 1 5 176 7026 7190 1.78E-54 190 MACF1_HUMAN reviewed "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)" MACF1 ABP620 ACF7 KIAA0465 KIAA1251 Homo sapiens (Human) 7388 Golgi to plasma membrane protein transport [GO:0043001]; positive regulation of axon extension [GO:0045773]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of microtubule-based process [GO:0032886]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060] GO:0003779; GO:0005509; GO:0005737; GO:0005794; GO:0005856; GO:0005874; GO:0005886; GO:0005913; GO:0010632; GO:0016055; GO:0016887; GO:0030177; GO:0032587; GO:0032886; GO:0042060; GO:0043001; GO:0044822; GO:0045773; GO:0051015; GO:0051893; GO:0098641 0 0 0 PF00307;PF13499;PF02187;PF00681;PF00435; Q9WUN2 CHOYP_IKK-EPSILON.3.3 m.65430 sp TBK1_MOUSE 36.006 661 375 13 9 653 1 629 1.78E-124 392 TBK1_MOUSE reviewed Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1) Tbk1 Mus musculus (Mouse) 729 activation of innate immune response [GO:0002218]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; dendritic cell proliferation [GO:0044565]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of xenophagy [GO:1904417] GO:0002218; GO:0003676; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0010629; GO:0018105; GO:0032727; GO:0032728; GO:0043123; GO:0044565; GO:0045087; GO:0045359; GO:0045944; GO:0050830; GO:0051219; GO:0051607; GO:1904417 0 0 0 PF00069; Q9Z2I6 CHOYP_LOC582715.1.1 m.10237 sp SV2C_RAT 37.356 348 204 5 2 336 116 462 1.78E-72 247 SV2C_RAT reviewed Synaptic vesicle glycoprotein 2C (Synaptic vesicle protein 2C) Sv2c Rattus norvegicus (Rat) 727 neurotransmitter transport [GO:0006836] GO:0006836; GO:0008021; GO:0016021; GO:0022857; GO:0030054; GO:0030672 0 0 cd06174; PF07690;PF13599;PF00083; S4R2P9 CHOYP_BRAFLDRAFT_78683.1.4 m.29747 sp NAC3_MOUSE 34.11 944 457 27 20 868 49 922 1.78E-141 446 NAC3_MOUSE reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Mus musculus (Mouse) 928 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; metal ion transport [GO:0030001]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005887; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0015368; GO:0016528; GO:0021537; GO:0030001; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; A4IF63 CHOYP_TRIM2.38.59 m.42017 sp TRIM2_BOVIN 34.146 82 53 1 41 122 627 707 1.79E-06 48.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_HMCN1.27.44 m.46599 sp HMCN1_MOUSE 21.689 687 441 31 105 728 1039 1691 1.79E-18 95.1 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E2AX35 CHOYP_LOC658640.1.2 m.36016 sp PROH4_CAMFO 34.27 178 98 6 50 213 27 199 1.79E-20 88.2 PROH4_CAMFO reviewed IDLSRF-like peptide EAG_01737 Camponotus floridanus (Florida carpenter ant) 201 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF00057; O14522 CHOYP_PTPRC.4.14 m.25886 sp PTPRT_HUMAN 32.737 559 334 15 349 881 747 1289 1.79E-68 254 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O73791 CHOYP_MEG11.3.25 m.14135 sp TIE2_DANRE 38.889 72 39 3 47 116 212 280 1.79E-07 51.6 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O75095 CHOYP_LOC579946.5.24 m.34617 sp MEGF6_HUMAN 30.352 369 203 9 65 390 639 996 1.79E-39 157 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75382 CHOYP_BRAFLDRAFT_205965.37.43 m.59628 sp TRIM3_HUMAN 27.778 126 85 3 170 293 622 743 1.79E-08 59.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P07314 CHOYP_GGT1.1.2 m.46130 sp GGT1_RAT 49.081 544 263 9 78 619 37 568 1.79E-169 497 GGT1_RAT reviewed Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] Ggt1 Ggt Rattus norvegicus (Rat) 568 aging [GO:0007568]; cellular response to oxidative stress [GO:0034599]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; peptide modification [GO:0031179]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; zymogen activation [GO:0031638] GO:0003840; GO:0005615; GO:0005886; GO:0005887; GO:0006536; GO:0006750; GO:0006751; GO:0007568; GO:0031179; GO:0031638; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374 PATHWAY: Sulfur metabolism; glutathione metabolism. 0 0 PF01019; P08289 CHOYP_ALPL.1.2 m.7282 sp PPBT_RAT 48.967 484 234 7 20 497 22 498 1.79E-149 441 PPBT_RAT reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" Alpl Rattus norvegicus (Rat) 524 cellular response to organic cyclic compound [GO:0071407]; cementum mineralization [GO:0071529]; dephosphorylation [GO:0016311]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; osteoblast differentiation [GO:0001649]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to lipopolysaccharide [GO:0032496]; response to vitamin D [GO:0033280] GO:0001649; GO:0001958; GO:0003006; GO:0004035; GO:0005578; GO:0005615; GO:0005886; GO:0016311; GO:0016462; GO:0031225; GO:0032496; GO:0033280; GO:0046677; GO:0046872; GO:0051384; GO:0065010; GO:0070062; GO:0071407; GO:0071529 0 0 0 PF00245; P0C6B8 CHOYP_LOC100367084.2.22 m.27296 sp SVEP1_RAT 25.764 687 411 24 212 815 435 1105 1.79E-39 165 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P10155 CHOYP_LOC100634688.6.6 m.63689 sp RO60_HUMAN 47.091 550 269 9 188 732 6 538 1.79E-160 477 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P37167 CHOYP_PGTG_12376.2.2 m.45195 sp ACTP_ACACA 30.147 136 91 1 11 146 2 133 1.79E-26 99.8 ACTP_ACACA reviewed Actophorin 0 Acanthamoeba castellanii (Amoeba) 138 actin filament depolymerization [GO:0030042] GO:0005737; GO:0015629; GO:0030042 0 0 cd11286; PF00241; P40423 CHOYP_LOC100372342.1.1 m.63404 sp SQH_DROME 79.532 171 33 1 1 169 1 171 1.79E-97 281 SQH_DROME reviewed "Myosin regulatory light chain sqh (Myosin regulatory light chain, nonmuscle) (MRLC-C) (Protein spaghetti-squash)" sqh CG3595 Drosophila melanogaster (Fruit fly) 174 "actin filament-based movement [GO:0030048]; apical constriction involved in gastrulation [GO:0003384]; border follicle cell migration [GO:0007298]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte [GO:0019749]; establishment of planar polarity [GO:0001736]; formation of a compartment boundary [GO:0060288]; imaginal disc-derived wing hair organization [GO:0035317]; mitotic cytokinesis [GO:0000281]; myosin II filament assembly [GO:0031036]; neurogenesis [GO:0022008]; nuclear axial expansion [GO:0035191]; ovarian follicle cell development [GO:0030707]; ovarian nurse cell to oocyte transport [GO:0007300]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of tube length, open tracheal system [GO:0035159]; spiracle morphogenesis, open tracheal system [GO:0035277]; tube formation [GO:0035148]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0003384; GO:0005509; GO:0005737; GO:0005829; GO:0005886; GO:0005912; GO:0005938; GO:0007298; GO:0007300; GO:0016324; GO:0016460; GO:0019749; GO:0022008; GO:0030048; GO:0030496; GO:0030707; GO:0031036; GO:0032036; GO:0032154; GO:0032956; GO:0035148; GO:0035159; GO:0035183; GO:0035191; GO:0035277; GO:0035317; GO:0042060; GO:0045177; GO:0051233; GO:0060288; GO:0090254 0 0 0 PF13405; P41824 CHOYP_YBOXH.2.4 m.3350 sp YBOXH_APLCA 76.106 113 27 0 2 114 9 121 1.79E-54 179 YBOXH_APLCA reviewed Y-box factor homolog (APY1) 0 Aplysia californica (California sea hare) 253 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355 0 0 cd04458; PF00313; P43143 CHOYP_CHRNA6.1.2 m.8129 sp ACHA6_RAT 30.323 310 208 2 27 330 35 342 1.79E-48 174 ACHA6_RAT reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) 493 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of dopamine secretion [GO:0033603]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0033603; GO:0035094; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; P47033 CHOYP_GLIPR2.1.1 m.22157 sp PRY3_YEAST 39.474 152 78 3 239 390 24 161 1.79E-25 112 PRY3_YEAST reviewed Cell wall protein PRY3 (Pathogenesis-related protein 3) PRY3 YJL078C J1027 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 881 sterol transport [GO:0015918] GO:0005576; GO:0009277; GO:0015918; GO:0031225 0 0 0 PF00188; Q00839 CHOYP_LOC578672.2.2 m.44884 sp HNRPU_HUMAN 48.337 451 225 5 206 655 241 684 1.79E-136 430 HNRPU_HUMAN reviewed Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120) HNRNPU HNRPU SAFA U21.1 Homo sapiens (Human) 825 "cellular response to dexamethasone stimulus [GO:0071549]; circadian regulation of gene expression [GO:0032922]; CRD-mediated mRNA stabilization [GO:0070934]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of telomere maintenance via telomerase [GO:0032211]; osteoblast differentiation [GO:0001649]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of gene expression [GO:0010628]; RNA processing [GO:0006396]" GO:0000398; GO:0001047; GO:0001649; GO:0003677; GO:0003723; GO:0005524; GO:0005634; GO:0005654; GO:0006396; GO:0009986; GO:0010467; GO:0010628; GO:0016020; GO:0030529; GO:0031012; GO:0032211; GO:0032922; GO:0034046; GO:0035326; GO:0036464; GO:0043021; GO:0044822; GO:0070034; GO:0070934; GO:0070937; GO:0071013; GO:0071549; GO:2000373 0 0 0 PF02037;PF00622; Q12912 CHOYP_LOC100379008.2.4 m.43192 sp LRMP_HUMAN 43.646 181 94 4 327 505 207 381 1.79E-32 136 LRMP_HUMAN reviewed Lymphoid-restricted membrane protein (Protein Jaw1) [Cleaved into: Processed lymphoid-restricted membrane protein] LRMP JAW1 Homo sapiens (Human) 555 immune system process [GO:0002376]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903] GO:0000922; GO:0002376; GO:0005635; GO:0005694; GO:0005789; GO:0005815; GO:0005887; GO:0006903; GO:0006906; GO:0007338; GO:0016020; GO:0016021 0 0 0 PF05781; Q15032 CHOYP_R3HDM1.1.1 m.36018 sp R3HD1_HUMAN 37.565 386 189 12 146 494 137 507 1.79E-50 197 R3HD1_HUMAN reviewed R3H domain-containing protein 1 R3HDM1 KIAA0029 R3HDM Homo sapiens (Human) 1099 0 GO:0044822 0 0 0 PF01424;PF12752; Q19QU3 CHOYP_BRAFLDRAFT_150340.1.4 m.7435 sp ZRAB2_PIG 58.621 145 37 3 10 154 6 127 1.79E-50 173 ZRAB2_PIG reviewed Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) ZRANB2 ZNF265 Sus scrofa (Pig) 328 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0006397; GO:0008270; GO:0008380; GO:0044822 0 0 0 PF00641; Q1ZXD6 CHOYP_BRAFLDRAFT_129004.9.15 m.42468 sp ROCO5_DICDI 26.032 315 183 13 493 802 1335 1604 1.79E-15 86.3 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q24157 CHOYP_LOC100749675.1.1 m.19143 sp BRN_DROME 34.673 199 126 3 99 294 80 277 1.79E-34 132 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q28852 CHOYP_contig_045655 m.53199 sp ATP5L_BOVIN 33.333 81 54 0 53 133 23 103 1.79E-07 50.1 ATP5L_BOVIN reviewed "ATP synthase subunit g, mitochondrial (ATPase subunit g)" ATP5L Bos taurus (Bovine) 103 ATP synthesis coupled proton transport [GO:0015986] GO:0000276; GO:0005753; GO:0015078; GO:0015986 0 0 0 PF04718; Q3MHY8 CHOYP_LOC100666110.1.1 m.52026 sp RBM7_BOVIN 47.059 119 58 3 5 119 9 126 1.79E-26 107 RBM7_BOVIN reviewed RNA-binding protein 7 (RNA-binding motif protein 7) RBM7 Bos taurus (Bovine) 262 meiotic cell cycle [GO:0051321] GO:0000166; GO:0003723; GO:0051321 0 0 0 PF00076; Q3UG20 CHOYP_LOC580083.1.1 m.22518 sp KMT2E_MOUSE 29.108 986 497 29 49 975 57 899 1.79E-97 354 KMT2E_MOUSE reviewed Histone-lysine N-methyltransferase 2E (Lysine N-methyltransferase 2E) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog) Kmt2e Mll5 Mus musculus (Mouse) 1868 "cell cycle arrest [GO:0007050]; cellular response to retinoic acid [GO:0071300]; DNA methylation [GO:0006306]; erythrocyte differentiation [GO:0030218]; histone H3-K4 methylation [GO:0051568]; neutrophil activation [GO:0042119]; neutrophil mediated immunity [GO:0002446]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of transcription, DNA-templated [GO:0045893]; retinoic acid receptor signaling pathway [GO:0048384]; transcription, DNA-templated [GO:0006351]" GO:0002446; GO:0003713; GO:0005654; GO:0006306; GO:0006351; GO:0007050; GO:0008270; GO:0016607; GO:0019899; GO:0030218; GO:0030854; GO:0042119; GO:0042800; GO:0043231; GO:0045171; GO:0045893; GO:0048384; GO:0051568; GO:0070688; GO:0071300 0 0 0 PF00628;PF00856; Q4KL91 CHOYP_AAEL_AAEL002214.2.2 m.25205 sp S36A4_XENLA 42.615 413 217 5 85 485 91 495 1.79E-113 347 S36A4_XENLA reviewed Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4) slc36a4 pat4 Xenopus laevis (African clawed frog) 522 amino acid transport [GO:0006865] GO:0006865; GO:0015293; GO:0016021 0 0 0 PF01490; Q4LDE5 CHOYP_TSP_13705.1.1 m.38345 sp SVEP1_HUMAN 38.596 114 65 3 61 169 992 1105 1.79E-14 73.6 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4UMH6 CHOYP_Y381.4.4 m.65940 sp Y381_RICFE 27.295 414 241 17 7 388 665 1050 1.79E-19 94.7 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5R6R6 CHOYP_LOC100891016.1.2 m.12585 sp PNDC1_PONAB 35.019 514 303 13 26 526 15 510 1.79E-89 287 PNDC1_PONAB reviewed Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 PNLDC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 520 0 GO:0003676; GO:0005634; GO:0016021 0 0 0 PF04857; Q5TZ51 CHOYP_LOC100899945.1.3 m.28405 sp MPV17_DANRE 40 175 102 2 1 172 1 175 1.79E-41 140 MPV17_DANRE reviewed Protein Mpv17 mpv17 zgc:63573 Danio rerio (Zebrafish) (Brachydanio rerio) 177 0 GO:0005743; GO:0016021 0 0 0 PF04117; Q5U3V9 CHOYP_LOC100702367.1.1 m.62543 sp SNF8_DANRE 62.14 243 92 0 2 244 3 245 1.79E-116 336 SNF8_DANRE reviewed Vacuolar-sorting protein SNF8 (ESCRT-II complex subunit VPS22) snf8 si:dkey-220f10.1 zgc:101578 Danio rerio (Zebrafish) (Brachydanio rerio) 258 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] GO:0000814; GO:0043328 0 0 0 PF04157; Q64127 CHOYP_BRAFLDRAFT_82426.18.20 m.60162 sp TIF1A_MOUSE 26.761 213 140 8 1 200 176 385 1.79E-06 54.3 TIF1A_MOUSE reviewed Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase Trim24) (Tripartite motif-containing protein 24) Trim24 Tif1 Tif1a Mus musculus (Mouse) 1051 "calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; transcription, DNA-templated [GO:0006351]" GO:0002039; GO:0003682; GO:0003713; GO:0004672; GO:0004842; GO:0005634; GO:0005719; GO:0005726; GO:0005737; GO:0006351; GO:0006468; GO:0008270; GO:0008285; GO:0010628; GO:0016567; GO:0016874; GO:0016922; GO:0030163; GO:0031647; GO:0034056; GO:0042981; GO:0043565; GO:0045892; GO:0045893; GO:0046777; GO:0055074; GO:0061630; GO:0070562; GO:0070577; GO:0071391; GO:1901796 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643; Q64338 CHOYP_DMOJ_GI17690.1.1 m.48369 sp PDE1C_MOUSE 52.362 508 196 7 90 555 81 584 1.79E-179 525 PDE1C_MOUSE reviewed "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Mus musculus (Mouse) 706 response to calcium ion [GO:0051592]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] GO:0004117; GO:0005929; GO:0007165; GO:0007608; GO:0046872; GO:0048101; GO:0051592 0 0 0 PF00233;PF08499; Q68CL5 CHOYP_LOC100370327.1.1 m.26834 sp TPGS2_HUMAN 52.535 217 100 3 7 222 13 227 1.79E-76 238 TPGS2_HUMAN reviewed Tubulin polyglutamylase complex subunit 2 (PGs2) TPGS2 C18orf10 HMFN0601 L17 Homo sapiens (Human) 300 0 GO:0005737; GO:0005874 0 0 0 0 Q69ZU8 CHOYP_AASI_1217.1.1 m.5703 sp ANKR6_MOUSE 30.151 199 131 4 5 200 39 232 1.79E-16 81.3 ANKR6_MOUSE reviewed Ankyrin repeat domain-containing protein 6 (Diversin) Ankrd6 Kiaa0957 Mus musculus (Mouse) 712 "negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]" GO:0005634; GO:0005737; GO:0043231; GO:0046330; GO:0090090; GO:2000096 0 0 0 PF12796; Q6GPB5 CHOYP_BRAFLDRAFT_126925.1.1 m.45641 sp ALKB5_XENLA 62.731 271 91 2 7 277 1 261 1.79E-118 352 ALKB5_XENLA reviewed RNA demethylase ALKBH5 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5) alkbh5 Xenopus laevis (African clawed frog) 360 mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; oxidative single-stranded RNA demethylation [GO:0035553]; response to hypoxia [GO:0001666]; spermatogenesis [GO:0007283] GO:0001666; GO:0005634; GO:0006397; GO:0006406; GO:0007283; GO:0016607; GO:0016706; GO:0035515; GO:0035553; GO:0046872 0 0 0 PF13532; Q6PDJ1 CHOYP_NEMVEDRAFT_V1G238894.7.11 m.61041 sp CAHD1_MOUSE 27.105 1081 675 38 2 1003 31 1077 1.79E-90 320 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6PFY8 CHOYP_TRI55.1.2 m.32797 sp TRI45_MOUSE 28.655 171 104 4 2 161 158 321 1.79E-09 62 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7LFX5 CHOYP_LOC100706438.1.2 m.3991 sp CHSTF_HUMAN 34.483 319 195 5 100 407 244 559 1.79E-59 205 CHSTF_HUMAN reviewed Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) CHST15 BRAG GALNAC4S6ST KIAA0598 Homo sapiens (Human) 561 chondroitin sulfate biosynthetic process [GO:0030206]; hexose biosynthetic process [GO:0019319] GO:0000139; GO:0016021; GO:0019319; GO:0030206; GO:0050656; GO:0050659 0 0 0 0 Q80TR4 CHOYP_BRAFLDRAFT_69264.3.6 m.26534 sp SLIT1_MOUSE 40 100 54 1 29 128 29 122 1.79E-15 79.7 SLIT1_MOUSE reviewed Slit homolog 1 protein (Slit-1) Slit1 Kiaa0813 Mus musculus (Mouse) 1531 axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; dorsal/ventral axon guidance [GO:0033563]; establishment of nucleus localization [GO:0040023]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of synapse assembly [GO:0051964]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; regulation of axonogenesis [GO:0050770]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; telencephalon cell migration [GO:0022029] GO:0005102; GO:0005509; GO:0005578; GO:0005615; GO:0005623; GO:0007409; GO:0007411; GO:0008045; GO:0008201; GO:0021772; GO:0022028; GO:0022029; GO:0031290; GO:0033563; GO:0035385; GO:0040023; GO:0048495; GO:0048812; GO:0048846; GO:0050770; GO:0050919; GO:0051964 0 0 0 PF00008;PF12661;PF02210;PF13855;PF01463;PF01462; Q8K203 CHOYP_NEIL3.1.3 m.15261 sp NEIL3_MOUSE 36.408 618 328 14 1 569 1 602 1.79E-120 371 NEIL3_MOUSE reviewed Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) Neil3 Mus musculus (Mouse) 606 base-excision repair [GO:0006284]; nucleotide-excision repair [GO:0006289] GO:0000405; GO:0003684; GO:0003690; GO:0003697; GO:0003906; GO:0005634; GO:0005654; GO:0006284; GO:0006289; GO:0008270; GO:0019104 0 0 0 PF06831;PF06839;PF00641; Q8R1C6 CHOYP_LOC664064.1.1 m.41606 sp MET22_MOUSE 37.891 256 150 6 63 315 138 387 1.79E-43 156 MET22_MOUSE reviewed Methyltransferase-like protein 22 (EC 2.1.1.-) Mettl22 Mus musculus (Mouse) 393 0 GO:0005634; GO:0005737; GO:0005794; GO:0005886; GO:0008168; GO:0043231 0 0 0 PF10294; Q8R431 CHOYP_LOC101158498.1.1 m.56778 sp MGLL_RAT 39.114 271 164 1 13 282 24 294 1.79E-69 220 MGLL_RAT reviewed Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL) Mgll Mgl2 Rattus norvegicus (Rat) 303 acylglycerol catabolic process [GO:0046464]; arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; lipid metabolic process [GO:0006629]; regulation of inflammatory response [GO:0050727]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; triglyceride catabolic process [GO:0019433] GO:0005811; GO:0005829; GO:0006629; GO:0006633; GO:0008289; GO:0009966; GO:0016020; GO:0016787; GO:0019369; GO:0019433; GO:0019898; GO:0045202; GO:0046464; GO:0047372; GO:0050727; GO:0051930 PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. {ECO:0000250|UniProtKB:O35678}. 0 0 PF12146; Q92193 CHOYP_CYIIB.2.2 m.64546 sp ACT_CRAVI 96.471 85 3 0 1 85 93 177 1.79E-53 171 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96D71 CHOYP_REPS1.2.2 m.43251 sp REPS1_HUMAN 41.538 195 108 4 336 525 274 467 1.79E-32 138 REPS1_HUMAN reviewed RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) REPS1 Homo sapiens (Human) 796 0 GO:0005509; GO:0005886; GO:0005905; GO:0017124 0 0 0 PF12763; Q99715 CHOYP_LOC101064693.2.2 m.50878 sp COCA1_HUMAN 37.563 197 102 8 1 193 2331 2510 1.79E-23 101 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q9C0T1 CHOYP_RL37.2.3 m.18754 sp RL37_EMENI 78.571 56 12 0 42 97 2 57 1.79E-25 94.7 RL37_EMENI reviewed 60S ribosomal protein L37 rpl37 AN4787 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 92 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9CWP8 CHOYP_LOC100198049.1.1 m.13866 sp DPOD4_MOUSE 38.235 102 61 2 6 106 7 107 1.79E-19 79.3 DPOD4_MOUSE reviewed DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) Pold4 Mus musculus (Mouse) 107 DNA-dependent DNA replication [GO:0006261]; DNA synthesis involved in DNA repair [GO:0000731]; positive regulation of endothelial cell proliferation [GO:0001938] GO:0000731; GO:0001938; GO:0003887; GO:0005634; GO:0006261; GO:0043625 0 0 0 PF04081; Q9EQD2 CHOYP_LOC100372174.1.2 m.20147 sp NPFF2_RAT 27.16 324 196 11 21 320 41 348 1.79E-23 104 NPFF2_RAT reviewed Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor) Npffr2 Gpr74 Npff2 Npgpr Rattus norvegicus (Rat) 417 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; regulation of adenylate cyclase activity [GO:0045761]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of MAPK cascade [GO:0043408]; response to peptide [GO:1901652] GO:0005887; GO:0007268; GO:0008188; GO:0015629; GO:0032870; GO:0042277; GO:0043408; GO:0045761; GO:1901652; GO:2000479 0 0 0 PF00001; Q9H0I3 CHOYP_LOC100374446.1.1 m.29971 sp CC113_HUMAN 47.863 351 174 4 26 375 25 367 1.79E-95 293 CC113_HUMAN reviewed Coiled-coil domain-containing protein 113 CCDC113 HSPC065 Homo sapiens (Human) 377 cilium assembly [GO:0042384] GO:0005654; GO:0005737; GO:0034451; GO:0042384; GO:0043234 0 0 0 PF13870; Q9LNB6 CHOYP_AAEL_AAEL006025.2.2 m.33806 sp HSOP1_ARATH 33.742 163 104 2 6 166 2 162 1.79E-21 96.3 HSOP1_ARATH reviewed Hsp70-Hsp90 organizing protein 1 (AtHop1) (Stress-induced-phosphoprotein 1) (STI1) HOP1 At1g12270 F5O11.2 Arabidopsis thaliana (Mouse-ear cress) 572 chaperone-mediated protein complex assembly [GO:0051131] GO:0005634; GO:0005829; GO:0051131; GO:0051879; GO:0070678 0 0 0 PF13414;PF13181; Q9NTG1 CHOYP_LOC100374042.1.1 m.26668 sp PKDRE_HUMAN 24.849 1159 716 35 25 1094 1114 2206 1.79E-96 342 PKDRE_HUMAN reviewed Polycystic kidney disease and receptor for egg jelly-related protein (PKD and REJ homolog) PKDREJ Homo sapiens (Human) 2253 acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0007340; GO:0016020; GO:0016021; GO:0050982 0 0 0 PF08016;PF01477;PF02010; Q9TTC7 CHOYP_FUT2.1.5 m.2949 sp FUT2_HYLLA 31.959 291 175 10 43 326 59 333 1.79E-32 126 FUT2_HYLLA reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Hylobates lar (Common gibbon) (White-handed gibbon) 343 protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q9VCA2 CHOYP_ORCT.5.6 m.55792 sp ORCT_DROME 38.809 554 309 8 1 541 1 537 1.79E-123 377 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9VZF4 CHOYP_LOC756678.2.2 m.58874 sp FBXW7_DROME 29.268 287 194 4 803 1083 982 1265 1.79E-41 169 FBXW7_DROME reviewed F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) ago CG15010 Drosophila melanogaster (Fruit fly) 1326 "axon guidance [GO:0007411]; branch fusion, open tracheal system [GO:0035147]; cellular response to hypoxia [GO:0071456]; DNA endoreduplication [GO:0042023]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of growth [GO:0045926]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of mitophagy [GO:1903146]; regulation of mitotic nuclear division [GO:0007088]; regulation of proteolysis [GO:0030162]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; trachea development [GO:0060438]; ventral cord development [GO:0007419]" GO:0005634; GO:0007088; GO:0007096; GO:0007411; GO:0007419; GO:0008054; GO:0016567; GO:0019005; GO:0030162; GO:0030332; GO:0031146; GO:0035147; GO:0042023; GO:0045926; GO:0060253; GO:0060438; GO:0071456; GO:1900038; GO:1903146 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9VZW5 CHOYP_LOC100642368.1.1 m.14558 sp FMAR_DROME 27.869 305 172 9 66 350 125 401 1.79E-20 96.3 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; A4IF63 CHOYP_BRAFLDRAFT_87322.7.10 m.52667 sp TRIM2_BOVIN 23.611 144 108 2 57 200 602 743 1.80E-07 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5D7J3 CHOYP_KNOP1.1.1 m.11909 sp KNOP1_BOVIN 38.462 104 57 3 342 443 354 452 1.80E-12 72.4 KNOP1_BOVIN reviewed Lysine-rich nucleolar protein 1 (Testis-specific gene 118 protein) KNOP1 TSG118 Bos taurus (Bovine) 452 0 GO:0005730; GO:0044822 0 0 0 PF15477; B3EWZ5 CHOYP_LOC100176264.2.2 m.48732 sp MLRP1_ACRMI 39.227 181 94 7 1 168 1629 1806 1.80E-30 119 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D2GXS7 CHOYP_LOC100371427.1.1 m.32454 sp TRIM2_AILME 28.44 109 76 1 19 125 623 731 1.80E-07 52 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D9IQ16 CHOYP_BRAFLDRAFT_119050.1.1 m.62633 sp GXN_ACRMI 26.78 295 168 9 26 309 53 310 1.80E-16 84.3 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 G5ED84 CHOYP_LOC100123307.1.1 m.13647 sp KLHL8_CAEEL 25.373 134 97 2 8 138 88 221 1.80E-06 54.7 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; H3BS89 CHOYP_LOC100118354.4.4 m.66763 sp T178B_HUMAN 25.17 147 95 3 39 185 141 272 1.80E-06 51.6 T178B_HUMAN reviewed Transmembrane protein 178B TMEM178B Homo sapiens (Human) 294 0 GO:0016021 0 0 0 PF13903; O13016 CHOYP_BRAFLDRAFT_68592.1.1 m.53611 sp PTN1_CHICK 53.22 295 127 3 31 323 2 287 1.80E-110 336 PTN1_CHICK reviewed Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (CPTP1) (Protein-tyrosine phosphatase 1B) (PTP-1B) PTPN1 PTP1B Gallus gallus (Chicken) 434 actin cytoskeleton reorganization [GO:0031532]; endoplasmic reticulum unfolded protein response [GO:0030968]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of endocytosis [GO:0030100]; regulation of signal transduction [GO:0009966] GO:0004725; GO:0005769; GO:0005789; GO:0009966; GO:0030100; GO:0030968; GO:0031532; GO:0035335 0 0 0 PF00102; O17287 CHOYP_TOMM22.1.1 m.48750 sp TOM22_CAEEL 42 100 56 1 25 122 4 103 1.80E-19 81.3 TOM22_CAEEL reviewed Mitochondrial import receptor subunit TOM22 homolog tomm-22 W10D9.5 Caenorhabditis elegans 109 protein import into mitochondrial matrix [GO:0030150]; protein import into mitochondrial outer membrane [GO:0045040] GO:0005742; GO:0030150; GO:0031307; GO:0045040 0 0 0 PF04281; O70277 CHOYP_LOC100374981.4.16 m.24874 sp TRIM3_RAT 22.814 263 181 7 310 557 488 743 1.80E-12 73.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O73746 CHOYP_TIMP3.4.9 m.28669 sp TIMP3_XENLA 33.981 103 64 3 20 120 26 126 1.80E-09 58.2 TIMP3_XENLA reviewed Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) timp3 Xenopus laevis (African clawed frog) 214 0 GO:0005578; GO:0008191; GO:0046872 0 0 0 PF00965; O88279 CHOYP_SLIT1.1.5 m.12362 sp SLIT1_RAT 45.714 210 90 1 29 214 30 239 1.80E-52 184 SLIT1_RAT reviewed Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) 1531 brain development [GO:0007420]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510] GO:0005509; GO:0005578; GO:0005615; GO:0007420; GO:0008201; GO:0021510; GO:0035385; GO:0043395; GO:0048495; GO:0048843; GO:0051964 0 0 0 PF00008;PF12661;PF02210;PF13855;PF01463;PF01462; O93530 CHOYP_LOC100368731.1.1 m.52133 sp WRN_XENLA 27.489 462 264 14 11 448 481 895 1.80E-36 146 WRN_XENLA reviewed Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-) (Focus-forming activity 1) (FFA-1) wrn ffa1 Xenopus laevis (African clawed frog) 1436 DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] GO:0000287; GO:0003677; GO:0005524; GO:0005634; GO:0006259; GO:0006260; GO:0006281; GO:0006310; GO:0008408; GO:0030145; GO:0043140 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; P02434 CHOYP_BRAFLDRAFT_67316.1.1 m.5348 sp RL35A_XENLA 72.477 109 29 1 31 139 3 110 1.80E-52 164 RL35A_XENLA reviewed 60S ribosomal protein L35a (L32) rpl35a Xenopus laevis (African clawed frog) 110 translation [GO:0006412] GO:0000049; GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01247; P11834 CHOYP_AAEL_AAEL003853.1.2 m.39529 sp OPCM_BOVIN 24.254 268 170 9 27 270 45 303 1.80E-08 60.1 OPCM_BOVIN reviewed Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) OPCML OBCAM OCAM Bos taurus (Bovine) 345 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225 0 0 0 PF07679; P21369 CHOYP_LOC100374320.1.1 m.54274 sp PNCA_ECOLI 35.398 226 108 5 101 317 2 198 1.80E-34 129 PNCA_ECOLI reviewed Pyrazinamidase/nicotinamidase (PZAase) (EC 3.5.1.-) (EC 3.5.1.19) (Nicotine deamidase) (NAMase) pncA nam ydjB b1768 JW1757 Escherichia coli (strain K12) 213 NAD metabolic process [GO:0019674]; nicotinamide metabolic process [GO:0006769]; pyridine nucleotide biosynthetic process [GO:0019363] GO:0005737; GO:0005829; GO:0006769; GO:0008936; GO:0019363; GO:0019674; GO:0046872 PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1. 0 0 PF00857; P23403 CHOYP_LOC100550844.6.7 m.62920 sp RS20_XENLA 91.262 103 7 2 4 104 3 105 1.80E-60 183 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P24049 CHOYP_RL17.2.7 m.34421 sp RL17_RAT 78.125 160 35 0 1 160 1 160 1.80E-92 270 RL17_RAT reviewed 60S ribosomal protein L17 (Amino acid starvation-induced protein) (ASI) (L23) Rpl17 Rattus norvegicus (Rat) 184 cellular response to amino acid starvation [GO:0034198]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; response to amino acid starvation [GO:1990928]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005844; GO:0006412; GO:0022625; GO:0031672; GO:0034198; GO:0070180; GO:1900087; GO:1990928 0 0 cd00336; PF00237; Q03601 CHOYP_BRAFLDRAFT_72273.2.2 m.51361 sp NHL1_CAEEL 33.333 126 65 3 15 123 42 165 1.80E-11 70.5 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q0II25 CHOYP_POP7.1.2 m.28401 sp POP7_BOVIN 53.333 105 42 1 28 125 15 119 1.80E-31 112 POP7_BOVIN reviewed Ribonuclease P protein subunit p20 (RNaseP protein p20) (EC 3.1.26.5) POP7 RPP20 Bos taurus (Bovine) 140 "RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; tRNA processing [GO:0008033]" GO:0004526; GO:0005634; GO:0005730; GO:0005737; GO:0008033; GO:0044822; GO:0090502 0 0 0 PF12328; Q0P4P2 CHOYP_LOC100635487.1.1 m.21915 sp FBCD1_XENTR 45.217 230 114 5 69 291 230 454 1.80E-58 196 FBCD1_XENTR reviewed Fibrinogen C domain-containing protein 1 fibcd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 457 0 GO:0008061; GO:0016021; GO:0046872 0 0 0 PF00147; Q15276 CHOYP_LOC585032.2.2 m.2879 sp RABE1_HUMAN 36.633 879 439 16 35 869 36 840 1.80E-140 443 RABE1_HUMAN reviewed Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) RABEP1 RAB5EP RABPT5 RABPT5A Homo sapiens (Human) 862 apoptotic process [GO:0006915]; endocytosis [GO:0006897]; membrane fusion [GO:0061025]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005096; GO:0005768; GO:0005769; GO:0006897; GO:0006915; GO:0015031; GO:0016192; GO:0030139; GO:0042803; GO:0043231; GO:0055037; GO:0061025 0 0 0 PF09311;PF03528; Q1JQC6 CHOYP_LOC100377662.1.1 m.8764 sp SIR4_BOVIN 56.584 281 122 0 22 302 29 309 1.80E-116 340 SIR4_BOVIN reviewed "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 3.5.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)" SIRT4 Bos taurus (Bovine) 315 cellular response to DNA damage stimulus [GO:0006974]; glutamine metabolic process [GO:0006541]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of insulin secretion [GO:0046676]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of lipid biosynthetic process [GO:0046889]; protein ADP-ribosylation [GO:0006471]; regulation of glutamine family amino acid metabolic process [GO:0000820]; regulation of pyruvate dehydrogenase activity [GO:1904182]; tricarboxylic acid metabolic process [GO:0072350] GO:0000820; GO:0003950; GO:0005739; GO:0005743; GO:0005759; GO:0006471; GO:0006541; GO:0006974; GO:0008270; GO:0034979; GO:0034983; GO:0046322; GO:0046676; GO:0046889; GO:0047708; GO:0061690; GO:0070403; GO:0072350; GO:1904182 0 0 0 PF02146; Q20930 CHOYP_LOC100868516.1.1 m.51522 sp MIG17_CAEEL 32.157 255 154 9 365 603 226 477 1.80E-30 129 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q21828 CHOYP_CRE_20365.2.3 m.50373 sp MPC1_CAEEL 57.407 108 45 1 55 162 20 126 1.80E-41 139 MPC1_CAEEL reviewed Probable mitochondrial pyruvate carrier 1 (MPC1) R07E5.13 Caenorhabditis elegans 137 mitochondrial pyruvate transport [GO:0006850] GO:0005743; GO:0006850; GO:0016021 0 0 0 PF03650; Q4R979 CHOYP_1433G.2.2 m.63451 sp RBM4_MACFA 43.571 140 75 2 10 146 69 207 1.80E-33 127 RBM4_MACFA reviewed RNA-binding protein 4 (RNA-binding motif protein 4) RBM4 QtsA-10585 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 364 "cap-independent translational initiation [GO:0002190]; cell differentiation [GO:0030154]; circadian regulation of translation [GO:0097167]; entrainment of circadian clock by photoperiod [GO:0043153]; IRES-dependent translational initiation [GO:0002192]; miRNA mediated inhibition of translation [GO:0035278]; mRNA processing [GO:0006397]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of translation in response to stress [GO:0032055]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of nucleocytoplasmic transport [GO:0046822]; response to arsenic-containing substance [GO:0046685]; RNA splicing [GO:0008380]; stress-activated MAPK cascade [GO:0051403]" GO:0000166; GO:0000381; GO:0002190; GO:0002192; GO:0003723; GO:0003729; GO:0003730; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006397; GO:0008270; GO:0008380; GO:0010494; GO:0016607; GO:0017148; GO:0030154; GO:0032055; GO:0035198; GO:0035278; GO:0036002; GO:0043153; GO:0045947; GO:0046685; GO:0046822; GO:0051149; GO:0051403; GO:0097157; GO:0097158; GO:0097167 0 0 0 PF00076;PF00098; Q56R14 CHOYP_BRAFLDRAFT_85511.14.23 m.44463 sp TRI33_XENLA 27.509 269 168 8 11 264 92 348 1.80E-19 97.4 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5E9S3 CHOYP_TCF21.1.1 m.25466 sp TCF21_BOVIN 74.419 86 19 1 27 112 77 159 1.80E-40 136 TCF21_BOVIN reviewed Transcription factor 21 (TCF-21) TCF21 Bos taurus (Bovine) 179 branching involved in ureteric bud morphogenesis [GO:0001658]; branchiomeric skeletal muscle development [GO:0014707]; bronchiole development [GO:0060435]; diaphragm development [GO:0060539]; embryonic digestive tract morphogenesis [GO:0048557]; epithelial cell differentiation [GO:0030855]; gland development [GO:0048732]; glomerulus development [GO:0032835]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; metanephric glomerular capillary formation [GO:0072277]; metanephric mesenchymal cell differentiation [GO:0072162]; morphogenesis of a branching structure [GO:0001763]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; palate development [GO:0060021]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; reproductive structure development [GO:0048608]; respiratory system development [GO:0060541]; Sertoli cell differentiation [GO:0060008]; sex determination [GO:0007530]; spleen development [GO:0048536]; ureteric bud development [GO:0001657]; vasculature development [GO:0001944] GO:0000122; GO:0001077; GO:0001078; GO:0001657; GO:0001658; GO:0001763; GO:0001944; GO:0005634; GO:0007530; GO:0014707; GO:0030855; GO:0032835; GO:0045944; GO:0048286; GO:0048536; GO:0048557; GO:0048608; GO:0048732; GO:0060008; GO:0060021; GO:0060425; GO:0060426; GO:0060435; GO:0060539; GO:0060541; GO:0060766; GO:0070888; GO:0072162; GO:0072277 0 0 0 PF00010; Q5F478 CHOYP_TVAG_291510.2.9 m.3296 sp ANR44_CHICK 24.736 473 304 6 958 1429 11 432 1.80E-28 128 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5PQQ6 CHOYP_NEMVEDRAFT_V1G167758.1.1 m.66572 sp IQCG_RAT 39.583 384 209 5 38 420 51 412 1.80E-89 280 IQCG_RAT reviewed IQ domain-containing protein G Iqcg Rattus norvegicus (Rat) 419 spermatid development [GO:0007286]; sperm axoneme assembly [GO:0007288] GO:0002177; GO:0005516; GO:0005737; GO:0007286; GO:0007288; GO:0031514; GO:0036126 0 0 0 PF00612; Q5R9F4 CHOYP_MGC83149.1.1 m.45540 sp RND3_PONAB 43.426 251 129 5 1 245 1 244 1.80E-70 219 RND3_PONAB reviewed Rho-related GTP-binding protein RhoE (Rho family GTPase 3) (Rnd3) RND3 RHOE Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 244 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264 0 0 0 PF00071; Q5ZK69 CHOYP_BRAFLDRAFT_104267.1.1 m.52332 sp PAAF1_CHICK 47.044 389 201 3 4 391 5 389 1.80E-123 365 PAAF1_CHICK reviewed Proteasomal ATPase-associated factor 1 (WD repeat-containing protein 71) PAAF1 WDR71 RCJMB04_12m19 Gallus gallus (Chicken) 392 0 GO:0000502 0 0 0 PF00400; Q60649 CHOYP_CLPB.3.3 m.55628 sp CLPB_MOUSE 62.011 358 130 2 237 588 307 664 1.80E-158 472 CLPB_MOUSE reviewed Caseinolytic peptidase B protein homolog (EC 3.6.1.3) (Suppressor of potassium transport defect 3) Clpb Skd3 Mus musculus (Mouse) 677 cellular response to heat [GO:0034605] GO:0005524; GO:0005739; GO:0016887; GO:0034605 0 0 0 PF07724;PF12796;PF10431; Q68F72 CHOYP_LOC100371088.1.1 m.52292 sp S15A4_XENLA 39.35 615 297 12 3 607 7 555 1.80E-129 396 S15A4_XENLA reviewed Solute carrier family 15 member 4 (Peptide transporter 4) slc15a4 Xenopus laevis (African clawed frog) 569 oligopeptide transport [GO:0006857]; protein transport [GO:0015031] GO:0006857; GO:0015031; GO:0015293; GO:0016021 0 0 cd06174; PF00854; Q6PFY8 CHOYP_NEMVEDRAFT_V1G198897.4.6 m.52548 sp TRI45_MOUSE 23.529 476 312 12 199 637 38 498 1.80E-24 112 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7G0 CHOYP_contig_006832 m.7795 sp Y068_OSHVF 21.617 606 394 17 25 556 29 627 1.80E-34 144 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6UX04 CHOYP_LOC100701406.1.1 m.23796 sp CWC27_HUMAN 54.244 483 172 12 20 465 1 471 1.80E-154 450 CWC27_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase CWC27 homolog (PPIase CWC27) (EC 5.2.1.8) (Antigen NY-CO-10) (Serologically defined colon cancer antigen 10) CWC27 SDCCAG10 UNQ438/PRO871 Homo sapiens (Human) 472 "mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]" GO:0000398; GO:0003755; GO:0006457; GO:0071013 0 0 0 PF00160; Q6ZR37 CHOYP_SMP_176920.1.1 m.200 sp PKHG7_HUMAN 35.983 239 135 3 1 223 120 356 1.80E-38 141 PKHG7_HUMAN reviewed Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 Homo sapiens (Human) 379 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF00621; Q7ZX03 CHOYP_FOXK2.1.1 m.56318 sp FOXK2_XENLA 45.053 657 244 21 41 632 13 617 1.80E-154 462 FOXK2_XENLA reviewed Forkhead box protein K2 (FoxK2) (Interleukin enhancer-binding factor 1) (ILF1) (xFoxK1) foxk2 foxk1 ilf1 Xenopus laevis (African clawed frog) 642 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000287; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0043565 0 0 0 PF00498;PF00250; Q96D70 CHOYP_RL8.2.10 m.14505 sp R3HD4_HUMAN 39.908 218 112 6 58 272 64 265 1.80E-44 154 R3HD4_HUMAN reviewed R3H domain-containing protein 4 R3HDM4 C19orf22 Homo sapiens (Human) 268 0 GO:0003676; GO:0005634 0 0 0 PF01424;PF13902; Q96HC4 CHOYP_contig_022643 m.25874 sp PDLI5_HUMAN 32.363 584 328 13 19 541 13 590 1.80E-85 279 PDLI5_HUMAN reviewed PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein) PDLIM5 ENH L9 Homo sapiens (Human) 596 cell growth involved in cardiac muscle cell development [GO:0061049]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of synapse assembly [GO:0051963] GO:0003779; GO:0005080; GO:0005829; GO:0005913; GO:0008270; GO:0014069; GO:0015629; GO:0016020; GO:0042805; GO:0043005; GO:0045211; GO:0051963; GO:0061001; GO:0061049; GO:0098641 0 0 0 PF15936;PF00412;PF00595; Q9BXW4 CHOYP_LOC100367880.1.1 m.12770 sp MLP3C_HUMAN 67.742 124 40 0 2 125 3 126 1.80E-58 180 MLP3C_HUMAN reviewed Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma) MAP1LC3C Homo sapiens (Human) 147 autophagosome assembly [GO:0000045]; cellular response to nitrogen starvation [GO:0006995]; macroautophagy [GO:0016236]; mitophagy [GO:0000422] GO:0000045; GO:0000421; GO:0000422; GO:0005776; GO:0005829; GO:0005874; GO:0006995; GO:0008017; GO:0012505; GO:0016236; GO:0031090; GO:0031410; GO:0031625 0 0 cd01611; PF02991; Q9DEA1 CHOYP_C43H6.6.1.2 m.16608 sp SLCB_DEIAC 27.703 148 87 7 146 287 10 143 1.80E-08 56.2 SLCB_DEIAC reviewed Snaclec agkicetin-C subunit beta (Antithrombin A subunit B) 0 Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) 146 0 GO:0005576 0 0 0 PF00059; Q9HAY6 CHOYP_BRAFLDRAFT_99974.1.1 m.25083 sp BCDO1_HUMAN 25.8 531 339 18 22 508 2 521 1.80E-39 154 BCDO1_HUMAN reviewed "Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1)" BCO1 BCDO BCDO1 BCMO1 Homo sapiens (Human) 547 beta-carotene metabolic process [GO:1901810]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; vitamin A biosynthetic process [GO:0035238] GO:0001523; GO:0003834; GO:0005829; GO:0035238; GO:0042572; GO:0042574; GO:0046872; GO:1901810 PATHWAY: Cofactor metabolism; retinol metabolism. 0 0 PF03055; Q9JHB4 CHOYP_WDR31.2.2 m.65613 sp WDR31_MOUSE 47.586 290 149 3 137 423 59 348 1.80E-88 276 WDR31_MOUSE reviewed WD repeat-containing protein 31 (Spermatid WD repeat-containing protein) (spWD) Wdr31 Mus musculus (Mouse) 367 0 0 0 0 0 PF00400; Q9JLC8 CHOYP_LOC100372627.1.1 m.63568 sp SACS_MOUSE 24.658 219 142 6 12 217 486 694 1.80E-09 60.5 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9LTD8 CHOYP_LOC100379052.1.2 m.22001 sp Y5279_ARATH 40.176 341 156 5 7 312 101 428 1.80E-72 235 Y5279_ARATH reviewed DUF21 domain-containing protein At5g52790 (CBS domain-containing protein CBSDUF5) CBSDUF5 At5g52790 F6N7.28 Arabidopsis thaliana (Mouse-ear cress) 500 0 GO:0016021 0 0 0 PF01595; Q9NG98 CHOYP_LOC100121991.1.1 m.13778 sp TOP3A_DROME 42.105 114 51 4 24 129 1139 1245 1.80E-18 83.2 TOP3A_DROME reviewed DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha) Top3alpha CG10123 Drosophila melanogaster (Fruit fly) 1250 developmental growth [GO:0048589]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; mitochondrial genome maintenance [GO:0000002]; tissue regeneration [GO:0042246] GO:0000002; GO:0000724; GO:0003677; GO:0003916; GO:0003917; GO:0005634; GO:0005694; GO:0005739; GO:0005829; GO:0006265; GO:0008270; GO:0042246; GO:0048589 0 0 cd00186; PF01131;PF01751;PF01396;PF06839; Q9NRK6 CHOYP_LOC754911.1.1 m.29438 sp ABCBA_HUMAN 60.87 391 152 1 1 390 345 735 1.80E-171 499 ABCBA_HUMAN reviewed "ATP-binding cassette sub-family B member 10, mitochondrial (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2)" ABCB10 Homo sapiens (Human) 738 transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005524; GO:0005743; GO:0006810; GO:0032592; GO:0042626; GO:0055085 0 0 0 PF00664;PF00005; Q9VQU9 CHOYP_ZNF18.1.1 m.15265 sp BOWEL_DROME 34.058 138 84 4 638 775 238 368 1.80E-15 84.3 BOWEL_DROME reviewed Protein bowel (Brother of odd with entrails limited) bowl CG10021 Drosophila melanogaster (Fruit fly) 744 "embryonic foregut morphogenesis [GO:0048617]; embryonic hindgut morphogenesis [GO:0048619]; embryonic pattern specification [GO:0009880]; hindgut morphogenesis [GO:0007442]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg morphogenesis [GO:0007480]; lateral inhibition [GO:0046331]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; periodic partitioning by pair rule gene [GO:0007366]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of glucose metabolic process [GO:0010906]; terminal region determination [GO:0007362]; transcription, DNA-templated [GO:0006351]; wing disc development [GO:0035220]" GO:0000122; GO:0000981; GO:0003676; GO:0005634; GO:0006351; GO:0007362; GO:0007366; GO:0007442; GO:0007480; GO:0009880; GO:0010906; GO:0016348; GO:0035220; GO:0045892; GO:0045893; GO:0045944; GO:0046331; GO:0046872; GO:0048617; GO:0048619 0 0 0 PF00096;PF13912; A2AIV2 CHOYP_VIR.1.1 m.51105 sp VIR_MOUSE 30.451 1596 936 45 518 2026 303 1811 1.81E-179 598 VIR_MOUSE reviewed Protein virilizer homolog Kiaa1429 Mus musculus (Mouse) 1811 mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0080009 0 0 0 PF15912; A7Z035 CHOYP_EPN4.1.3 m.10807 sp EPN4_BOVIN 44.869 497 196 20 1 463 4 456 1.81E-100 324 EPN4_BOVIN reviewed Clathrin interactor 1 (Epsin-4) CLINT1 EPN4 Bos taurus (Bovine) 643 endocytosis [GO:0006897] GO:0005654; GO:0005798; GO:0005802; GO:0006897; GO:0008289; GO:0016020; GO:0030136; GO:0048471 0 0 0 PF01417; B0JZG0 CHOYP_S23A2.2.3 m.60743 sp S23A2_XENTR 38.596 570 333 8 64 630 67 622 1.81E-128 396 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; B6ZK77 CHOYP_contig_018728 m.21984 sp IRL1B_DANRE 28.235 170 107 8 144 306 246 407 1.81E-06 54.3 IRL1B_DANRE reviewed Interleukin-1 receptor accessory protein-like 1-B il1rapl1b Danio rerio (Zebrafish) (Brachydanio rerio) 700 neuron remodeling [GO:0016322]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0005737; GO:0005886; GO:0007165; GO:0016021; GO:0016322; GO:0043025; GO:0043679; GO:0050808 0 0 0 PF01582; F4KF65 CHOYP_IMA2.1.2 m.35753 sp IMPA9_ARATH 28.791 521 302 21 29 497 10 513 1.81E-47 175 IMPA9_ARATH reviewed Importin subunit alpha-9 (IMPa-9) IMPA9 At5g03070 F15A17.100 Arabidopsis thaliana (Mouse-ear cress) 519 NLS-bearing protein import into nucleus [GO:0006607] GO:0005643; GO:0005654; GO:0005829; GO:0006607; GO:0008139; GO:0008565 0 0 0 PF00514; O09164 CHOYP_BRAFLDRAFT_68934.2.2 m.62964 sp SODE_MOUSE 30.682 88 57 3 1 87 79 163 1.81E-06 48.9 SODE_MOUSE reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) Sod3 Mus musculus (Mouse) 251 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to reactive oxygen species [GO:0000302] GO:0000302; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005796; GO:0005802; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; O14522 CHOYP_PTPRK.8.20 m.8333 sp PTPRT_HUMAN 31.767 979 579 22 628 1535 479 1439 1.81E-140 473 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14657 CHOYP_LOC100367552.1.1 m.59303 sp TOR1B_HUMAN 41.27 315 179 3 37 350 26 335 1.81E-90 277 TOR1B_HUMAN reviewed Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B) TOR1B DQ1 FKSG18 Homo sapiens (Human) 336 chaperone mediated protein folding requiring cofactor [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763]; protein homooligomerization [GO:0051260]; response to unfolded protein [GO:0006986] GO:0005524; GO:0005635; GO:0005783; GO:0005788; GO:0006986; GO:0007029; GO:0016887; GO:0031965; GO:0051085; GO:0051260; GO:0070062; GO:0071763 0 0 0 PF06309; O54910 CHOYP_IKBE.1.1 m.30206 sp IKBE_MOUSE 41.41 227 121 6 121 340 122 343 1.81E-40 148 IKBE_MOUSE reviewed NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) Nfkbie Ikbe Mus musculus (Mouse) 364 D-serine transport [GO:0042942] GO:0005794; GO:0042942; GO:0048471 0 0 0 PF12796; O75382 CHOYP_PE2R3.2.2 m.61863 sp TRIM3_HUMAN 29.744 195 112 8 249 433 565 744 1.81E-13 75.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O93209 CHOYP_LOC100495321.3.3 m.53802 sp POL_FFV 29.143 175 110 3 41 215 241 401 1.81E-08 60.5 POL_FFV reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Feline foamy virus (FFV) (Feline syncytial virus) 1156 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; O95817 CHOYP_TRIADDRAFT_51704.1.1 m.21277 sp BAG3_HUMAN 50 42 21 0 7 48 21 62 1.81E-06 53.9 BAG3_HUMAN reviewed BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) 575 brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cellular response to heat [GO:1900034]; spinal cord development [GO:0021510] GO:0000774; GO:0005737; GO:0005829; GO:0005886; GO:0005913; GO:0006457; GO:0007420; GO:0008625; GO:0010664; GO:0021510; GO:0030018; GO:0043005; GO:0043066; GO:0050821; GO:0071260; GO:0097192; GO:0098641; GO:1900034 0 0 0 PF02179;PF00397; P08775 CHOYP_contig_003079 m.3383 sp RPB1_MOUSE 37.288 59 36 1 222 279 1862 1920 1.81E-07 55.8 RPB1_MOUSE reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) Polr2a Rpii215 Rpo2-1 Mus musculus (Mouse) 1970 "cellular response to oxygen levels [GO:0071453]; DNA-templated transcription, termination [GO:0006353]; piRNA metabolic process [GO:0034587]; positive regulation of RNA splicing [GO:0033120]; response to organic cyclic compound [GO:0014070]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0001047; GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0005719; GO:0006353; GO:0006366; GO:0014070; GO:0031625; GO:0033120; GO:0034587; GO:0044822; GO:0046872; GO:0071453 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; P10079 CHOYP_LOC100366518.1.6 m.9513 sp FBP1_STRPU 42.879 646 357 8 228 873 291 924 1.81E-164 509 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11137 CHOYP_UAFA.3.8 m.34702 sp MTAP2_HUMAN 53.077 130 48 3 1606 1727 1649 1773 1.81E-27 125 MTAP2_HUMAN reviewed Microtubule-associated protein 2 (MAP-2) MAP2 Homo sapiens (Human) 1827 central nervous system neuron development [GO:0021954]; dendrite morphogenesis [GO:0048813]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175] GO:0000226; GO:0001578; GO:0002162; GO:0005198; GO:0005730; GO:0005737; GO:0005874; GO:0005875; GO:0008017; GO:0021954; GO:0031175; GO:0043005; GO:0048813 0 0 0 PF08377;PF00418; P17972 CHOYP_TRIADDRAFT_1922.1.1 m.11684 sp KCNAW_DROME 30.297 505 307 11 10 499 12 486 1.81E-70 237 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P28192 CHOYP_MEG10.47.91 m.45616 sp PTP4_CAEEL 39.216 102 59 2 1 99 731 832 1.81E-18 82.4 PTP4_CAEEL reviewed Tyrosine-protein phosphatase 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4) ptp-4 K04D7.4 Caenorhabditis elegans 1159 0 GO:0004725; GO:0016021 0 0 0 PF00041;PF00102; P28828 CHOYP_LOC578045.4.5 m.61073 sp PTPRM_MOUSE 31.919 542 341 11 112 631 896 1431 1.81E-71 254 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P30546 CHOYP_CRE-OCTR-1.1.1 m.10548 sp HRH1_BOVIN 25.414 181 129 4 8 186 5 181 1.81E-11 69.3 HRH1_BOVIN reviewed Histamine H1 receptor (H1R) (HH1R) HRH1 Bos taurus (Bovine) 491 cellular response to histamine [GO:0071420]; eosinophil chemotaxis [GO:0048245]; G-protein coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; modulation of synaptic transmission [GO:0050804]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of vasoconstriction [GO:0045907]; regulation of vascular permeability [GO:0043114]; regulation of vasoconstriction [GO:0019229] GO:0004969; GO:0005887; GO:0006954; GO:0007186; GO:0007200; GO:0019229; GO:0043114; GO:0045907; GO:0048245; GO:0050804; GO:0071420 0 0 0 PF00001; P39872 CHOYP_RL3.3.7 m.33543 sp RL3_BOVIN 76.522 115 27 0 1 115 84 198 1.81E-63 201 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; P57695 CHOYP_LOC100533289.2.6 m.2298 sp GLRA1_BOVIN 42.446 417 197 8 21 400 36 446 1.81E-116 350 GLRA1_BOVIN reviewed Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) GLRA1 Bos taurus (Bovine) 457 "acrosome reaction [GO:0007340]; action potential [GO:0001508]; adult walking behavior [GO:0007628]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; inhibitory postsynaptic potential [GO:0060080]; ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of transmission of nerve impulse [GO:0051970]; neuromuscular process controlling posture [GO:0050884]; neuropeptide signaling pathway [GO:0007218]; positive regulation of acrosome reaction [GO:2000344]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; response to alcohol [GO:0097305]; response to amino acid [GO:0043200]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]" GO:0001508; GO:0001964; GO:0002087; GO:0005887; GO:0006811; GO:0006821; GO:0006936; GO:0007218; GO:0007340; GO:0007601; GO:0007628; GO:0008270; GO:0009897; GO:0016594; GO:0016934; GO:0022824; GO:0030054; GO:0030425; GO:0030977; GO:0034707; GO:0043005; GO:0043025; GO:0043200; GO:0043204; GO:0043231; GO:0045202; GO:0045211; GO:0050884; GO:0051970; GO:0060012; GO:0060013; GO:0060077; GO:0060080; GO:0071230; GO:0071294; GO:0071361; GO:0097305; GO:2000344 0 0 0 PF02931;PF02932; P61374 CHOYP_ISL1.1.1 m.10993 sp ISL1_RAT 64.881 336 87 5 13 348 9 313 1.81E-158 452 ISL1_RAT reviewed Insulin gene enhancer protein ISL-1 (Islet-1) Isl1 Rattus norvegicus (Rat) 349 "atrial septum morphogenesis [GO:0060413]; axon regeneration [GO:0031103]; cardiac cell fate determination [GO:0060913]; cardiac muscle cell myoblast differentiation [GO:0060379]; cardiac right ventricle morphogenesis [GO:0003215]; cellular response to glucocorticoid stimulus [GO:0071385]; endocardial cushion morphogenesis [GO:0003203]; innervation [GO:0060384]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response [GO:0050728]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein homodimerization activity [GO:0090074]; neural crest cell migration [GO:0001755]; outflow tract septum morphogenesis [GO:0003148]; pancreas development [GO:0031016]; peripheral nervous system neuron axonogenesis [GO:0048936]; pharyngeal system development [GO:0060037]; pituitary gland development [GO:0021983]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of histone acetylation [GO:0035066]; positive regulation of insulin secretion [GO:0032024]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-1 alpha production [GO:0032730]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of secondary heart field cardioblast proliferation [GO:0003266]; regulation of transcription, DNA-templated [GO:0006355]; retinal ganglion cell axon guidance [GO:0031290]; secondary heart field specification [GO:0003139]; sensory system development [GO:0048880]; spinal cord motor neuron cell fate specification [GO:0021520]; trigeminal nerve development [GO:0021559]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; visceral motor neuron differentiation [GO:0021524]" GO:0000978; GO:0001077; GO:0001105; GO:0001158; GO:0001755; GO:0003139; GO:0003148; GO:0003203; GO:0003215; GO:0003266; GO:0003682; GO:0005634; GO:0005654; GO:0006355; GO:0008270; GO:0008284; GO:0010575; GO:0016922; GO:0021520; GO:0021524; GO:0021559; GO:0021983; GO:0030331; GO:0031016; GO:0031103; GO:0031290; GO:0032024; GO:0032725; GO:0032729; GO:0032730; GO:0032731; GO:0032735; GO:0032755; GO:0032760; GO:0033147; GO:0035066; GO:0042517; GO:0043388; GO:0043524; GO:0043565; GO:0045665; GO:0045766; GO:0045944; GO:0048880; GO:0048936; GO:0050728; GO:0055010; GO:0060037; GO:0060379; GO:0060384; GO:0060413; GO:0060913; GO:0071385; GO:0071657; GO:0090074; GO:0090090 0 0 0 PF00046;PF00412; Q01484 CHOYP_TVAG_227760.2.4 m.32725 sp ANK2_HUMAN 32.692 208 115 6 42 227 130 334 1.81E-22 99.4 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q06210 CHOYP_GFPT1.2.2 m.60328 sp GFPT1_HUMAN 66.372 226 73 1 1 223 1 226 1.81E-102 316 GFPT1_HUMAN reviewed Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) GFPT1 GFAT GFPT Homo sapiens (Human) 699 carbohydrate metabolic process [GO:0005975]; cellular response to insulin stimulus [GO:0032869]; circadian regulation of gene expression [GO:0032922]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glucosamine biosynthetic process [GO:0006042]; glutamine metabolic process [GO:0006541]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of glycogen biosynthetic process [GO:0045719]; protein homotetramerization [GO:0051289]; response to sucrose [GO:0009744]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] GO:0004360; GO:0005829; GO:0005975; GO:0006002; GO:0006042; GO:0006047; GO:0006048; GO:0006112; GO:0006541; GO:0009744; GO:0016597; GO:0030246; GO:0032869; GO:0032922; GO:0036498; GO:0045719; GO:0051289; GO:0070062 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000250|UniProtKB:P82808}. 0 0 PF01380; Q10981 CHOYP_FUT2.2.5 m.15353 sp FUT2_HUMAN 35.636 275 158 8 94 358 65 330 1.81E-44 159 FUT2_HUMAN reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2) (SE2) (Secretor blood group alpha-2-fucosyltransferase) (Secretor factor) (Se)" FUT2 SEC2 Homo sapiens (Human) 343 carbohydrate metabolic process [GO:0005975]; L-fucose catabolic process [GO:0042355]; protein glycosylation [GO:0006486] GO:0005794; GO:0005975; GO:0006486; GO:0008107; GO:0008417; GO:0016021; GO:0032580; GO:0042355; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q149N8 CHOYP_SHPRH.3.3 m.55774 sp SHPRH_HUMAN 58.225 383 151 2 192 574 659 1032 1.81E-157 494 SHPRH_HUMAN reviewed "E3 ubiquitin-protein ligase SHPRH (EC 3.6.4.-) (EC 6.3.2.-) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)" SHPRH KIAA2023 Homo sapiens (Human) 1683 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0000786; GO:0003677; GO:0004386; GO:0004842; GO:0005524; GO:0005634; GO:0006281; GO:0006334; GO:0006974; GO:0008270; GO:0016874; GO:0031625 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00271;PF00538;PF00176; Q196X6 CHOYP_BRAFLDRAFT_90042.1.2 m.54729 sp VF232_IIV3 27.333 150 98 3 125 269 581 724 1.81E-09 64.3 VF232_IIV3 reviewed Putative ubiquitin thioesterase 232R (EC 3.4.19.12) IIV3-084L Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) 844 "DNA-templated transcription, termination [GO:0006353]" GO:0006353; GO:0036459 0 0 0 PF02338;PF07498; Q29550 CHOYP_LOC100371351.1.1 m.5264 sp EST1_PIG 32.105 570 336 18 10 556 6 547 1.81E-78 261 EST1_PIG reviewed Liver carboxylesterase (EC 3.1.1.1) (Proline-beta-naphthylamidase) (Retinyl ester hydrolase) (REH) 0 Sus scrofa (Pig) 566 0 GO:0005788; GO:0052689 0 0 0 PF00135; Q3UHD1 CHOYP_LOC100123035.1.1 m.11336 sp BAI1_MOUSE 20.32 625 419 19 596 1169 561 1157 1.81E-16 89.4 BAI1_MOUSE reviewed Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) 1582 cell surface receptor signaling pathway [GO:0007166]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965] GO:0004930; GO:0005886; GO:0007166; GO:0014069; GO:0016021; GO:0016525; GO:0051965 0 0 0 PF00002;PF16489;PF01825;PF02793;PF00090; Q502M6 CHOYP_LOC100638883.2.3 m.32804 sp ANR29_DANRE 40.102 197 115 2 18 211 4 200 1.81E-37 135 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q53G44 CHOYP_LOC101165968.4.7 m.50972 sp IF44L_HUMAN 28.894 443 293 9 34 472 11 435 1.81E-48 176 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q64270 CHOYP_LOC100375693.1.2 m.186 sp EI2BA_RAT 60.656 305 116 2 5 306 1 304 1.81E-128 371 EI2BA_RAT reviewed Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha) Eif2b1 Eif2ba Rattus norvegicus (Rat) 305 cellular response to stimulus [GO:0051716]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; oligodendrocyte development [GO:0014003]; positive regulation of GTPase activity [GO:0043547]; response to amino acid starvation [GO:1990928]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413] GO:0003743; GO:0005525; GO:0005737; GO:0005850; GO:0005851; GO:0006412; GO:0006413; GO:0009408; GO:0009749; GO:0014003; GO:0019003; GO:0043434; GO:0043547; GO:0051716; GO:1905098; GO:1990928 0 0 0 PF01008; Q6DWJ6 CHOYP_AAEL_AAEL006283.1.1 m.44770 sp GP139_HUMAN 21.393 201 137 7 24 213 159 349 1.81E-06 51.2 GP139_HUMAN reviewed Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) (G-protein-coupled receptor PGR3) GPR139 GPRG1 PGR3 Homo sapiens (Human) 353 G-protein coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200] GO:0005886; GO:0007186; GO:0007200; GO:0008188; GO:0016021 0 0 0 PF00001; Q6MG82 CHOYP_1433E.2.2 m.63378 sp PRRT1_RAT 44.444 99 53 1 41 137 196 294 1.81E-18 82.8 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6NT55 CHOYP_BRAFLDRAFT_61250.8.14 m.44214 sp CP4FN_HUMAN 41.458 480 257 8 32 499 57 524 1.81E-123 374 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q6P2X9 CHOYP_IFIH1.11.14 m.61920 sp MOT12_XENTR 33.482 224 138 1 30 253 13 225 1.81E-36 146 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6TDP4 CHOYP_LOC101373190.1.1 m.16098 sp KLH17_HUMAN 47.541 122 64 0 39 160 121 242 1.81E-35 132 KLH17_HUMAN reviewed Kelch-like protein 17 (Actinfilin) KLHL17 Homo sapiens (Human) 642 actin cytoskeleton organization [GO:0030036]; brain development [GO:0007420]; protein ubiquitination [GO:0016567] GO:0005615; GO:0007420; GO:0014069; GO:0015629; GO:0016567; GO:0030036; GO:0030054; GO:0031463; GO:0032839; GO:0032947; GO:0043025; GO:0045211; GO:0051015 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6ZPS2 CHOYP_DWIL_GK23042.1.1 m.38795 sp CRNS1_MOUSE 32.743 113 73 2 27 138 717 827 1.81E-15 75.1 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q6ZS10 CHOYP_LOC100557507.1.1 m.27277 sp CL17A_HUMAN 34.646 127 77 4 75 200 254 375 1.81E-15 77 CL17A_HUMAN reviewed "C-type lectin domain family 17, member A (Prolectin)" CLEC17A Homo sapiens (Human) 378 0 GO:0005537; GO:0009986; GO:0016021; GO:0042806; GO:0046872 0 0 0 PF00059; Q7TN31 CHOYP_LOC100374066.1.1 m.19566 sp AGGF1_MOUSE 44.444 306 156 7 295 589 404 706 1.81E-65 230 AGGF1_MOUSE reviewed Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (mVG5Q) Aggf1 Vg5q Mus musculus (Mouse) 711 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; mRNA processing [GO:0006397]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of RNA splicing [GO:0043484]; vasculogenesis [GO:0001570] GO:0001525; GO:0001570; GO:0001938; GO:0003723; GO:0005576; GO:0005737; GO:0006397; GO:0007155; GO:0016607; GO:0043484; GO:0045766; GO:0048471; GO:0071011 0 0 0 PF00498;PF01585; Q80T11 CHOYP_USH1G.1.1 m.27003 sp USH1G_MOUSE 35.516 504 263 15 1 485 1 461 1.81E-80 260 USH1G_MOUSE reviewed Usher syndrome type-1G protein homolog (Jackson shaker protein) (Scaffold protein containing ankyrin repeats and SAM domain) Ush1g Sans Mus musculus (Mouse) 461 equilibrioception [GO:0050957]; inner ear morphogenesis [GO:0042472]; inner ear receptor cell differentiation [GO:0060113]; inner ear receptor stereocilium organization [GO:0060122]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0001917; GO:0005737; GO:0005829; GO:0005886; GO:0007605; GO:0015629; GO:0016020; GO:0030507; GO:0032391; GO:0036064; GO:0042472; GO:0042803; GO:0045494; GO:0050953; GO:0050957; GO:0060113; GO:0060122 0 0 0 PF12796;PF00536; Q8BWQ6 CHOYP_RA54B.1.1 m.9068 sp CP062_MOUSE 63.596 228 77 1 7 234 150 371 1.81E-93 296 CP062_MOUSE reviewed UPF0505 protein C16orf62 homolog 0 Mus musculus (Mouse) 963 Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] GO:0005769; GO:0006893; GO:0015031; GO:0016021 0 0 0 0 Q8TDN4 CHOYP_AAEL_AAEL005863.1.2 m.22088 sp CABL1_HUMAN 40.798 326 157 7 174 481 326 633 1.81E-66 228 CABL1_HUMAN reviewed CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) CABLES1 CABLES Homo sapiens (Human) 633 cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of cell cycle [GO:0051726] GO:0005634; GO:0005829; GO:0007049; GO:0051301; GO:0051726 0 0 0 PF00134; Q8TER0 CHOYP_LOC100890161.3.3 m.59352 sp SNED1_HUMAN 47.887 284 131 3 20 302 26 293 1.81E-72 270 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q96MM6 CHOYP_BRAFLDRAFT_208197.10.21 m.40433 sp HS12B_HUMAN 28.7 223 141 6 21 228 453 672 1.81E-25 108 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9D4C5 CHOYP_LOC100707027.1.1 m.33337 sp EAF1_MOUSE 54.054 111 51 0 8 118 9 119 1.81E-39 140 EAF1_MOUSE reviewed ELL-associated factor 1 Eaf1 Mus musculus (Mouse) 268 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0006351; GO:0008023; GO:0008134; GO:0015030; GO:0016607; GO:0032783; GO:0043231; GO:0045171; GO:0045944 0 0 0 PF09816; Q9ESN6 CHOYP_BRAFLDRAFT_124722.3.3 m.32547 sp TRIM2_MOUSE 27.778 180 111 9 82 254 536 703 1.81E-07 55.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H8W5 CHOYP_LOC100370588.2.19 m.8069 sp TRI45_HUMAN 25.275 273 183 12 4 261 127 393 1.81E-08 60.1 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9H8W5 CHOYP_LOC100374741.24.83 m.21312 sp TRI45_HUMAN 23.188 207 153 5 13 216 135 338 1.81E-06 53.1 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9H8W5 CHOYP_TIF1A.1.8 m.4 sp TRI45_HUMAN 25.067 375 218 17 1 341 12 357 1.81E-14 80.1 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9JHB4 CHOYP_WDR31.1.2 m.63736 sp WDR31_MOUSE 45.161 93 50 1 50 141 59 151 1.81E-18 83.6 WDR31_MOUSE reviewed WD repeat-containing protein 31 (Spermatid WD repeat-containing protein) (spWD) Wdr31 Mus musculus (Mouse) 367 0 0 0 0 0 PF00400; Q9R1R2 CHOYP_BRAFLDRAFT_255103.15.18 m.59559 sp TRIM3_MOUSE 25 152 110 3 89 237 593 743 1.81E-08 58.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UKN7 CHOYP_LOC100901924.2.3 m.55059 sp MYO15_HUMAN 33.148 540 326 11 18 554 3012 3519 1.81E-90 308 MYO15_HUMAN reviewed Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) 3530 inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0007626; GO:0016459; GO:0032420; GO:0042472; GO:0070062 0 0 0 PF00373;PF00612;PF00063;PF00784;PF07653; Q9V6X7 CHOYP_PHUM_PHUM091880.1.1 m.50944 sp OFUT1_DROME 48.225 338 158 3 1 321 54 391 1.81E-112 335 OFUT1_DROME reviewed GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Neurotic protein) (Peptide-O-fucosyltransferase 1) (O-FucT-1) O-fut1 nti CG12366 Drosophila melanogaster (Fruit fly) 402 "embryo development [GO:0009790]; endocytosis [GO:0006897]; fucose metabolic process [GO:0006004]; lateral inhibition [GO:0046331]; negative regulation of Notch signaling pathway [GO:0045746]; Notch signaling pathway [GO:0007219]; O-glycan processing [GO:0016266]; positive regulation of Notch signaling pathway [GO:0045747]; protein catabolic process [GO:0030163]; protein O-linked glycosylation [GO:0006493]; regulation of Notch signaling pathway [GO:0008593]; regulation of transcription, DNA-templated [GO:0006355]; single organismal cell-cell adhesion [GO:0016337]" GO:0005112; GO:0005737; GO:0005783; GO:0006004; GO:0006355; GO:0006493; GO:0006897; GO:0007219; GO:0008417; GO:0008593; GO:0009790; GO:0016266; GO:0016337; GO:0030163; GO:0031410; GO:0045746; GO:0045747; GO:0046331; GO:0046922 PATHWAY: Protein modification; protein glycosylation. 0 0 PF10250; Q9VW71 CHOYP_FAT4.7.10 m.44743 sp FAT2_DROME 28.873 426 277 14 14 434 3014 3418 1.81E-34 140 FAT2_DROME reviewed Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) 4699 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; defense response to Gram-negative bacterium [GO:0050829]; epithelium development [GO:0060429]; establishment of planar polarity of follicular epithelium [GO:0042247]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; foregut morphogenesis [GO:0007440]; germarium-derived egg chamber formation [GO:0007293]; growth of a germarium-derived egg chamber [GO:0007295]; hindgut morphogenesis [GO:0007442]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of imaginal disc growth [GO:0045571]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; positive regulation of innate immune response [GO:0045089]; salivary gland development [GO:0007431] GO:0004872; GO:0005509; GO:0005886; GO:0005887; GO:0005925; GO:0007156; GO:0007293; GO:0007295; GO:0007424; GO:0007431; GO:0007440; GO:0007442; GO:0009925; GO:0016339; GO:0030950; GO:0042247; GO:0044331; GO:0045089; GO:0045571; GO:0048477; GO:0050829; GO:0050839; GO:0060429 0 0 0 PF00028;PF02210; Q9VZW5 CHOYP_LOC100215960.1.1 m.44034 sp FMAR_DROME 33.333 171 87 8 11 164 87 247 1.81E-11 65.5 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; Q9W5U2 CHOYP_LOC100864276.1.1 m.18732 sp CHIT3_DROME 37.421 636 340 15 1 589 1044 1668 1.81E-128 419 CHIT3_DROME reviewed Probable chitinase 3 (EC 3.2.1.14) (Probable chitinase 1) Cht3 Cht1 CG18140 Drosophila melanogaster (Fruit fly) 2286 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0006032; GO:0008061 0 0 0 PF01607;PF00704; Q9XSU7 CHOYP_LOC100373506.6.8 m.40910 sp RL27_CANLF 78.226 124 27 0 1 124 1 124 1.81E-67 203 RL27_CANLF reviewed 60S ribosomal protein L27 RPL27 B173 Canis lupus familiaris (Dog) (Canis familiaris) 136 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00467;PF01777; A8Y5T1 CHOYP_LOC100366787.1.1 m.65795 sp CA194_DANRE 46.386 166 87 2 2 167 1 164 1.82E-45 149 CA194_DANRE reviewed Uncharacterized protein C1orf194 homolog si:ch211-163l21.7 Danio rerio (Zebrafish) (Brachydanio rerio) 164 0 0 0 0 0 PF12494; A8Y5T1 CHOYP_TAZ.1.1 m.8372 sp CA194_DANRE 46.386 166 87 2 2 167 1 164 1.82E-45 149 CA194_DANRE reviewed Uncharacterized protein C1orf194 homolog si:ch211-163l21.7 Danio rerio (Zebrafish) (Brachydanio rerio) 164 0 0 0 0 0 PF12494; O00142 CHOYP_KITM.2.2 m.65985 sp KITM_HUMAN 51.174 213 102 2 100 312 47 257 1.82E-71 225 KITM_HUMAN reviewed "Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)" TK2 Homo sapiens (Human) 265 deoxycytidine metabolic process [GO:0046092]; DNA biosynthetic process [GO:0071897]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside salvage [GO:0043097]; thymidine metabolic process [GO:0046104] GO:0004137; GO:0004797; GO:0005524; GO:0005759; GO:0006139; GO:0019206; GO:0043097; GO:0046092; GO:0046104; GO:0071897 0 0 0 PF01712; O75074 CHOYP_LOC100375513.1.1 m.45802 sp LRP3_HUMAN 29.452 146 97 5 59 202 66 207 1.82E-06 53.5 LRP3_HUMAN reviewed Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105) LRP3 Homo sapiens (Human) 770 receptor-mediated endocytosis [GO:0006898] GO:0005905; GO:0006898; GO:0016021 0 0 0 PF00431;PF00057; P02707 CHOYP_CLC10.3.5 m.4847 sp LECH_CHICK 33.103 145 72 7 29 171 81 202 1.82E-16 77.4 LECH_CHICK reviewed Hepatic lectin 0 Gallus gallus (Chicken) 207 endocytosis [GO:0006897] GO:0006897; GO:0016021; GO:0030246 0 0 0 PF00059; P34611 CHOYP_LOC100882263.1.1 m.48839 sp NCL1_CAEEL 38.828 273 163 4 608 879 558 827 1.82E-55 209 NCL1_CAEEL reviewed B-box type zinc finger protein ncl-1 ncl-1 ZK112.2 Caenorhabditis elegans 851 negative regulation of ribosome biogenesis [GO:0090071] GO:0005737; GO:0008270; GO:0090071 0 0 0 PF01436;PF00643; P43114 CHOYP_PI2R.3.4 m.49766 sp PE2R4_RAT 28 375 208 8 7 325 6 374 1.82E-34 134 PE2R4_RAT reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Rattus norvegicus (Rat) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to interleukin-1 [GO:0070555]; response to organic cyclic compound [GO:0014070]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0001934; GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0010628; GO:0010727; GO:0010840; GO:0014070; GO:0014911; GO:0030819; GO:0031965; GO:0032570; GO:0032720; GO:0032757; GO:0033624; GO:0034695; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050714; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0070555; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P52758 CHOYP_BRAFLDRAFT_118789.2.3 m.59829 sp UK114_HUMAN 65.909 132 45 0 43 174 1 132 1.82E-59 184 UK114_HUMAN reviewed Ribonuclease UK114 (EC 3.1.-.-) (14.5 kDa translational inhibitor protein) (p14.5) (Heat-responsive protein 12) (UK114 antigen homolog) HRSP12 PSP Homo sapiens (Human) 137 brain development [GO:0007420]; G1 to G0 transition [GO:0070314]; kidney development [GO:0001822]; lung development [GO:0030324]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of translation [GO:0017148]; regulation of translational termination [GO:0006449]; response to lipid [GO:0033993]; response to salt [GO:1902074] GO:0001822; GO:0005634; GO:0005737; GO:0005739; GO:0005777; GO:0005829; GO:0006449; GO:0007420; GO:0016892; GO:0017148; GO:0030324; GO:0033993; GO:0036041; GO:0044822; GO:0046914; GO:0050680; GO:0070062; GO:0070314; GO:1902074; GO:1904012; GO:1904013 0 0 0 PF01042; P55918 CHOYP_LOC555374.2.2 m.56629 sp MFAP4_BOVIN 46.364 220 109 5 80 292 37 254 1.82E-56 185 MFAP4_BOVIN reviewed Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) 255 cell adhesion [GO:0007155]; cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; regulation of collagen metabolic process [GO:0010712]; UV protection [GO:0009650] GO:0001527; GO:0007155; GO:0009650; GO:0010712; GO:0031012; GO:0043206; GO:0048251; GO:0070062; GO:0071493; GO:0071953 0 0 0 PF00147; P85298 CHOYP_ARHGAP8.1.1 m.25503 sp RHG08_HUMAN 50 406 168 5 119 490 9 413 1.82E-129 387 RHG08_HUMAN reviewed Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8) ARHGAP8 Homo sapiens (Human) 464 positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005737; GO:0005829; GO:0007165; GO:0051056; GO:0070374 0 0 0 PF13716;PF00620; Q28FE2 CHOYP_MED31.1.1 m.6270 sp MED31_XENTR 81.25 112 21 0 19 130 1 112 1.82E-65 198 MED31_XENTR reviewed Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit soh1) med31 soh1 TEgg024a05.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0003713; GO:0006351; GO:0006357; GO:0016592; GO:0070847 0 0 0 PF05669; Q2YDJ4 CHOYP_DGRI_GH21309.1.1 m.48525 sp HINT3_BOVIN 50 136 66 2 11 144 47 182 1.82E-47 155 HINT3_BOVIN reviewed Histidine triad nucleotide-binding protein 3 (HINT-3) (EC 3.-.-.-) (HINT-4) HINT3 HINT4 Bos taurus (Bovine) 182 0 GO:0000166; GO:0005634; GO:0005737; GO:0016787; GO:0070062 0 0 0 0 Q32KU3 CHOYP_BRAFLDRAFT_246978.1.1 m.6916 sp MORN2_BOVIN 56.962 79 34 0 76 154 1 79 1.82E-25 95.5 MORN2_BOVIN reviewed MORN repeat-containing protein 2 MORN2 Bos taurus (Bovine) 79 0 0 0 0 0 PF02493; Q33BP8 CHOYP_FOXN2_3.1.1 m.8518 sp FOXN3_PIG 36.292 507 194 20 18 455 18 464 1.82E-73 243 FOXN3_PIG reviewed Forkhead box protein N3 (Checkpoint suppressor 1) FOXN3 CHES1 Sus scrofa (Pig) 485 "cell cycle [GO:0007049]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007049; GO:0043565 0 0 0 PF00250; Q460N5 CHOYP_BRAFLDRAFT_84838.4.6 m.53026 sp PAR14_HUMAN 23.965 1039 687 25 681 1691 19 982 1.82E-63 243 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_LOC580251.1.5 m.22535 sp SVEP1_HUMAN 32.51 243 142 8 2 241 427 650 1.82E-22 103 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5ND28 CHOYP_MEG10.18.91 m.24277 sp SREC_MOUSE 36.207 174 102 6 1 172 217 383 1.82E-21 99 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5ND28 CHOYP_SREC.2.4 m.50160 sp SREC_MOUSE 45.679 81 43 1 2 82 262 341 1.82E-13 68.9 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q6DBY2 CHOYP_BRAFLDRAFT_117937.1.1 m.18686 sp NAA50_DANRE 80.392 153 30 0 3 155 2 154 1.82E-91 266 NAA50_DANRE reviewed N-alpha-acetyltransferase 50 (EC 2.3.1.-) (N-acetyltransferase NAT13) (NatE catalytic subunit) naa50 mak3 nat13 Danio rerio (Zebrafish) (Brachydanio rerio) 168 "mitotic sister chromatid cohesion, centromeric [GO:0071962]; N-terminal protein amino acid acetylation [GO:0006474]; somitogenesis [GO:0001756]" GO:0001756; GO:0004596; GO:0005737; GO:0006474; GO:0010485; GO:0031248; GO:0052858; GO:0071962 0 0 0 PF00583; Q6DJK9 CHOYP_BRAFLDRAFT_119424.1.1 m.15350 sp CC130_XENLA 51.307 306 141 3 18 322 1 299 1.82E-104 318 CC130_XENLA reviewed Coiled-coil domain-containing protein 130 ccdc130 Xenopus laevis (African clawed frog) 384 0 0 0 0 0 PF04502; Q6JHU9 CHOYP_CREBBP.1.1 m.48304 sp CBP_RAT 75 116 18 2 252 365 329 435 1.82E-40 159 CBP_RAT reviewed CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) 2442 "cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; histone acetylation [GO:0016573]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003682; GO:0003684; GO:0003713; GO:0004402; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0008283; GO:0016407; GO:0016573; GO:0016604; GO:0033613; GO:0034644; GO:0042975; GO:0043234; GO:0043426; GO:0045893; GO:0045944; GO:0046332; GO:0048511; GO:0060355; GO:0070555; GO:0098609; GO:1900087; GO:1901224 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q6P9H4 CHOYP_CNKR2.3.3 m.57021 sp CNKR3_HUMAN 44.407 295 155 3 14 307 7 293 1.82E-69 245 CNKR3_HUMAN reviewed Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) CNKSR3 MAGI1 Homo sapiens (Human) 555 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765] GO:0005737; GO:0010765; GO:0016020; GO:0033137; GO:0070373 0 0 0 PF10534;PF06663;PF00595;PF00536; Q6PFY8 CHOYP_TRI45.20.23 m.55182 sp TRI45_MOUSE 27.823 248 158 6 5 239 127 366 1.82E-15 82.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6ZTW0 CHOYP_BRAFLDRAFT_121821.2.2 m.31442 sp TPGS1_HUMAN 30.078 256 157 5 16 250 33 287 1.82E-35 130 TPGS1_HUMAN reviewed Tubulin polyglutamylase complex subunit 1 (PGs1) TPGS1 C19orf20 Homo sapiens (Human) 290 adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; protein polyglutamylation [GO:0018095]; sperm axoneme assembly [GO:0007288]; vesicle localization [GO:0051648] GO:0005737; GO:0005813; GO:0005874; GO:0007268; GO:0007275; GO:0007288; GO:0018095; GO:0030424; GO:0030425; GO:0030534; GO:0031514; GO:0051648; GO:0070740 0 0 0 0 Q86Y13 CHOYP_NEMVEDRAFT_V1G247590.2.13 m.11764 sp DZIP3_HUMAN 31.765 85 53 2 73 155 459 540 1.82E-06 51.6 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8IWZ3 CHOYP_LOC753709.31.44 m.52242 sp ANKH1_HUMAN 35.941 409 243 14 1 394 285 689 1.82E-47 177 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8NDZ2 CHOYP_LOC100524072.1.1 m.47888 sp SIMC1_HUMAN 20.629 286 200 7 447 721 476 745 1.82E-08 62 SIMC1_HUMAN reviewed SUMO-interacting motif-containing protein 1 SIMC1 C5orf25 Homo sapiens (Human) 872 0 GO:0032184 0 0 0 0 Q8NHV1 CHOYP_LOC100694118.1.1 m.35217 sp GIMA7_HUMAN 31.443 194 119 4 12 191 9 202 1.82E-23 97.4 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8TDB6 CHOYP_PAR14.12.17 m.57325 sp DTX3L_HUMAN 49.761 209 95 2 1525 1724 532 739 1.82E-56 214 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8VIJ6 CHOYP_LOC593522.1.2 m.5381 sp SFPQ_MOUSE 53.986 276 127 0 137 412 283 558 1.82E-98 317 SFPQ_MOUSE reviewed "Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" Sfpq Psf Mus musculus (Mouse) 699 "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to DNA damage stimulus [GO:0006974]; chromosome organization [GO:0051276]; double-strand break repair via homologous recombination [GO:0000724]; histone H3 deacetylation [GO:0070932]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of sister chromatid cohesion [GO:0045876]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0000380; GO:0000724; GO:0000785; GO:0000976; GO:0000980; GO:0001047; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006974; GO:0016363; GO:0042382; GO:0042752; GO:0042754; GO:0042826; GO:0044212; GO:0044822; GO:0045876; GO:0045892; GO:0048511; GO:0051276; GO:0051726; GO:0070932; GO:0090575; GO:1902177 0 0 0 PF08075;PF00076; Q90Y54 CHOYP_NEMVEDRAFT_V1G120454.1.2 m.27938 sp JAG1B_DANRE 37.2 250 144 7 1 249 312 549 1.82E-42 157 JAG1B_DANRE reviewed Protein jagged-1b (Jagged1b) (Jagged3) jag1b jag3 Danio rerio (Zebrafish) (Brachydanio rerio) 1213 auditory receptor cell development [GO:0060117]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; dorsal/ventral pattern formation [GO:0009953]; face morphogenesis [GO:0060325]; fin regeneration [GO:0031101]; inner ear morphogenesis [GO:0042472]; liver development [GO:0001889]; Notch signaling pathway [GO:0007219]; otolith morphogenesis [GO:0032474]; pancreas development [GO:0031016]; semicircular canal development [GO:0060872]; semicircular canal morphogenesis [GO:0048752]; thyroid gland development [GO:0030878] GO:0001889; GO:0005509; GO:0007219; GO:0009953; GO:0016021; GO:0030878; GO:0031016; GO:0031101; GO:0032474; GO:0042472; GO:0048752; GO:0060117; GO:0060325; GO:0060351; GO:0060872 0 0 0 PF01414;PF00008;PF07645;PF12661;PF07657; Q91WV7 CHOYP_STIP1.2.2 m.54722 sp SLC31_MOUSE 32.915 638 364 23 71 674 43 650 1.82E-94 309 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q920N2 CHOYP_LOC100369411.1.1 m.1071 sp BPL1_MOUSE 40.212 567 321 12 299 854 158 717 1.82E-134 421 BPL1_MOUSE reviewed Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] Hlcs Mus musculus (Mouse) 722 cell proliferation [GO:0008283]; histone biotinylation [GO:0071110]; histone modification [GO:0016570]; protein biotinylation [GO:0009305]; response to biotin [GO:0070781] GO:0000785; GO:0004077; GO:0004078; GO:0004079; GO:0004080; GO:0005524; GO:0005652; GO:0005737; GO:0005739; GO:0005829; GO:0008283; GO:0009305; GO:0009374; GO:0016363; GO:0016570; GO:0018271; GO:0019899; GO:0042803; GO:0070781; GO:0071110 0 0 0 PF02237;PF03099;PF09825; Q96JB1 CHOYP_LOC577805.3.4 m.46026 sp DYH8_HUMAN 35.266 638 402 5 2 639 1023 1649 1.82E-108 394 DYH8_HUMAN reviewed "Dynein heavy chain 8, axonemal (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8)" DNAH8 Homo sapiens (Human) 4490 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018; GO:0016887; GO:0030286 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q9CUU3 CHOYP_SYCP2.1.2 m.47476 sp SYCP2_MOUSE 29.412 272 181 5 100 370 127 388 1.82E-29 132 SYCP2_MOUSE reviewed Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) Sycp2 Scp2 Mus musculus (Mouse) 1500 cell division [GO:0051301]; female meiotic division [GO:0007143]; fertilization [GO:0009566]; male genitalia morphogenesis [GO:0048808]; male meiosis [GO:0007140]; negative regulation of apoptotic process [GO:0043066]; organ morphogenesis [GO:0009887] GO:0000795; GO:0000800; GO:0003677; GO:0005654; GO:0007140; GO:0007143; GO:0009566; GO:0009887; GO:0043066; GO:0046982; GO:0048808; GO:0051301 0 0 0 0 Q9ESJ1 CHOYP_LOC663548.2.2 m.44873 sp CABL1_MOUSE 46.64 253 117 3 206 442 318 568 1.82E-66 225 CABL1_MOUSE reviewed CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1) Cables1 Cables Mus musculus (Mouse) 568 blood coagulation [GO:0007596]; cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; nervous system development [GO:0007399]; regulation of cell cycle [GO:0051726] GO:0000082; GO:0005654; GO:0005829; GO:0007399; GO:0007596; GO:0030426; GO:0051301; GO:0051726 0 0 0 PF00134; Q9I931 CHOYP_BRAFLDRAFT_224255.1.1 m.44865 sp FUCL1_ANGJA 29.762 84 56 1 73 153 73 156 1.82E-08 54.7 FUCL1_ANGJA reviewed Fucolectin-1 0 Anguilla japonica (Japanese eel) 178 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9NUV9 CHOYP_LOC100017680.2.2 m.42292 sp GIMA4_HUMAN 38.71 279 164 3 111 384 22 298 1.82E-58 197 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9NX94 CHOYP_contig_041737 m.47799 sp WBP1L_HUMAN 43.86 57 30 1 40 96 17 71 1.82E-09 57.8 WBP1L_HUMAN reviewed WW domain binding protein 1-like (Outcome predictor in acute leukemia 1) WBP1L C10orf26 OPA1L Homo sapiens (Human) 342 0 GO:0016021 0 0 0 PF11669; Q9R1R2 CHOYP_BRAFLDRAFT_241726.17.22 m.42086 sp TRIM3_MOUSE 28.333 120 81 3 76 191 625 743 1.82E-08 57.4 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9VCA8 CHOYP_LOC100889142.2.4 m.42235 sp ANKHM_DROME 30.297 472 260 16 238 701 550 960 1.82E-35 148 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VK68 CHOYP_LOC100176678.1.1 m.66881 sp PITH1_DROME 54.839 93 37 2 3 93 4 93 1.82E-26 100 PITH1_DROME reviewed PITH domain-containing protein CG6153 CG6153 Drosophila melanogaster (Fruit fly) 211 cellular response to DNA damage stimulus [GO:0006974] GO:0006974 0 0 0 PF06201; A2AVA0 CHOYP_LOC100208285.2.2 m.50451 sp SVEP1_MOUSE 29.557 203 113 7 34 219 458 647 1.83E-09 61.2 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A4FV97 CHOYP_LOC100116719.1.1 m.58 sp RL1D1_BOVIN 34.021 388 237 9 60 439 50 426 1.83E-45 170 RL1D1_BOVIN reviewed Ribosomal L1 domain-containing protein 1 RSL1D1 Bos taurus (Bovine) 482 maturation of LSU-rRNA [GO:0000470]; osteoblast differentiation [GO:0001649]; regulation of apoptotic process [GO:0042981]; regulation of cellular senescence [GO:2000772]; regulation of protein localization [GO:0032880] GO:0000470; GO:0001649; GO:0003723; GO:0005730; GO:0016020; GO:0030686; GO:0032880; GO:0042981; GO:0044822; GO:2000772 0 0 cd00403; PF00687; C3ZWH9 CHOYP_CID2A.1.1 m.4479 sp CID2A_BRAFL 68.75 96 30 0 11 106 35 130 1.83E-43 140 CID2A_BRAFL reviewed CDGSH iron-sulfur domain-containing protein 2 homolog A BRAFLDRAFT_285975 Branchiostoma floridae (Florida lancelet) (Amphioxus) 131 0 GO:0005789; GO:0016021; GO:0046872; GO:0051537 0 0 0 PF10660;PF09360; F4JLS1 CHOYP_SORBIDRAFT_06G032450.1.1 m.16356 sp LDL3_ARATH 26.68 506 289 18 36 480 618 1102 1.83E-33 140 LDL3_ARATH reviewed Lysine-specific histone demethylase 1 homolog 3 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 3) (Protein LSD1-like 3) LDL3 At4g16310/At4g16320 dl4185w/dl4190w FCAALL.342/ FCAALL.344 Arabidopsis thaliana (Mouse-ear cress) 1628 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0016491; GO:0016569 0 0 0 PF01593;PF04433; G8HTB6 CHOYP_BRAFLDRAFT_69120.3.3 m.40386 sp ZPP_ACRMI 26.567 335 225 10 320 641 69 395 1.83E-21 100 ZPP_ACRMI reviewed ZP domain-containing protein 0 Acropora millepora (Staghorn coral) 414 0 GO:0016021 0 0 0 PF00100; O60290 CHOYP_DI3L2.1.1 m.61978 sp ZN862_HUMAN 27.511 687 445 14 32 709 455 1097 1.83E-68 248 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; O75051 CHOYP_PLXA2.2.3 m.37476 sp PLXA2_HUMAN 26.264 1938 1209 69 49 1865 56 1894 1.83E-158 537 PLXA2_HUMAN reviewed Plexin-A2 (Semaphorin receptor OCT) PLXNA2 KIAA0463 OCT PLXN2 UNQ209/PRO235 Homo sapiens (Human) 1894 branchiomotor neuron axon guidance [GO:0021785]; centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756] GO:0001756; GO:0002116; GO:0005886; GO:0005887; GO:0017154; GO:0021785; GO:0021915; GO:0021935; GO:0030334; GO:0048841; GO:0051642; GO:0060037; GO:0060174; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; O75095 CHOYP_BRAFLDRAFT_224574.2.18 m.8658 sp MEGF6_HUMAN 35.602 191 111 6 3 193 772 950 1.83E-24 103 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O88630 CHOYP_LOC593134.1.1 m.29711 sp GOSR1_MOUSE 64.516 248 79 2 18 256 3 250 1.83E-114 331 GOSR1_MOUSE reviewed Golgi SNAP receptor complex member 1 (28 kDa Golgi SNARE protein) (28 kDa cis-Golgi SNARE p28) (GOS-28) Gosr1 Gs28 Mus musculus (Mouse) 250 "ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; regulation of vesicle targeting, to, from or within Golgi [GO:0048209]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion [GO:0006906]" GO:0000139; GO:0000149; GO:0005484; GO:0005794; GO:0005797; GO:0005801; GO:0005829; GO:0006888; GO:0006891; GO:0006906; GO:0015031; GO:0016020; GO:0016021; GO:0031201; GO:0042147; GO:0048209 0 0 0 0 P06868 CHOYP_PLMN.10.11 m.49635 sp PLMN_BOVIN 36.157 484 216 18 263 685 113 564 1.83E-73 256 PLMN_BOVIN reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; response to heat [GO:0009408]; tissue remodeling [GO:0048771] GO:0004252; GO:0005102; GO:0005576; GO:0007596; GO:0009408; GO:0019904; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P21329 CHOYP_LOC100890271.2.2 m.65844 sp RTJK_DROFU 19.726 365 258 17 112 458 29 376 1.83E-06 54.3 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P39060 CHOYP_SUCB1.1.1 m.41300 sp COIA1_HUMAN 45.294 170 88 4 5 170 1578 1746 1.83E-44 160 COIA1_HUMAN reviewed Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin] COL18A1 Homo sapiens (Human) 1754 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; endothelial cell morphogenesis [GO:0001886]; extracellular matrix organization [GO:0030198]; negative regulation of cell proliferation [GO:0008285]; organ morphogenesis [GO:0009887]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; response to drug [GO:0042493]; response to hydrostatic pressure [GO:0051599]; visual perception [GO:0007601] GO:0001525; GO:0001886; GO:0005198; GO:0005576; GO:0005581; GO:0005604; GO:0005615; GO:0005788; GO:0007155; GO:0007601; GO:0008284; GO:0008285; GO:0009887; GO:0030198; GO:0030335; GO:0030574; GO:0031012; GO:0042493; GO:0042802; GO:0046872; GO:0051599; GO:0070062; GO:2000353 0 0 0 PF01391;PF06121;PF06482;PF01392; P42029 CHOYP_CPIPJ_CPIJ015079.1.1 m.39675 sp NDUA8_BOVIN 38.065 155 90 3 9 163 7 155 1.83E-30 112 NDUA8_BOVIN reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 (Complex I-19kD) (CI-19kD) (Complex I-PGIV) (CI-PGIV) (NADH-ubiquinone oxidoreductase 19 kDa subunit) NDUFA8 Bos taurus (Bovine) 172 0 GO:0005747; GO:0005758; GO:0008137 0 0 0 PF06747; P42674 CHOYP_BP10.2.3 m.50179 sp BP10_PARLI 39.382 259 140 8 35 280 67 321 1.83E-46 168 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P47911 CHOYP_BRAFLDRAFT_114734.4.8 m.15359 sp RL6_MOUSE 63 200 70 2 116 314 100 296 1.83E-78 244 RL6_MOUSE reviewed 60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) Rpl6 Mus musculus (Mouse) 296 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; P61315 CHOYP_LOC100206557.1.1 m.11857 sp G3ST3_MOUSE 30.028 353 201 14 55 380 57 390 1.83E-37 144 G3ST3_MOUSE reviewed "Galactose-3-O-sulfotransferase 3 (Gal3ST-3) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 3) (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3)" Gal3st3 Mus musculus (Mouse) 431 glycolipid biosynthetic process [GO:0009247] GO:0001733; GO:0009247; GO:0016021; GO:0032580; GO:0050694 PATHWAY: Protein modification; carbohydrate sulfation. 0 0 PF06990; P70665 CHOYP_BRAFLDRAFT_217332.1.2 m.25808 sp SIAE_MOUSE 26.761 142 91 4 17 156 401 531 1.83E-12 67.8 SIAE_MOUSE reviewed Sialate O-acetylesterase (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit] Siae Ysg2 Mus musculus (Mouse) 541 carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682] GO:0001681; GO:0002682; GO:0005615; GO:0005764; GO:0005975; GO:0070062 0 0 0 PF03629; P86854 CHOYP_LOC100690738.1.3 m.57697 sp PLCL_MYTGA 22.404 183 110 5 19 198 3 156 1.83E-08 54.7 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q17BU3 CHOYP_LOC590618.1.1 m.40928 sp KIF1A_AEDAE 46.429 336 151 8 1 311 244 575 1.83E-74 252 KIF1A_AEDAE reviewed Kinesin-like protein unc-104 unc-104 AAEL004812 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 1644 synaptic vesicle transport [GO:0048489]; vesicle transport along microtubule [GO:0047496] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005875; GO:0047496; GO:0048489 0 0 0 PF12473;PF00498;PF12423;PF00225;PF16183;PF00169; Q29611 CHOYP_BRAFLDRAFT_216655.1.1 m.22758 sp CLN3_CANLF 42.336 137 76 1 8 141 302 438 1.83E-35 130 CLN3_CANLF reviewed Battenin (Protein CLN3) CLN3 Canis lupus familiaris (Dog) (Canis familiaris) 438 amyloid precursor protein catabolic process [GO:0042987]; arginine transport [GO:0015809]; ceramide metabolic process [GO:0006672]; galactosylceramide metabolic process [GO:0006681]; globoside metabolic process [GO:0001575]; glucosylceramide metabolic process [GO:0006678]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; negative regulation of apoptotic process [GO:0043066]; receptor-mediated endocytosis [GO:0006898]; sphingomyelin metabolic process [GO:0006684]; vacuolar transport [GO:0007034]; vesicle transport along microtubule [GO:0047496] GO:0000139; GO:0001575; GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005783; GO:0005794; GO:0005795; GO:0005802; GO:0005886; GO:0005901; GO:0006672; GO:0006678; GO:0006681; GO:0006684; GO:0006898; GO:0007034; GO:0007042; GO:0008021; GO:0015809; GO:0016021; GO:0030176; GO:0031301; GO:0035752; GO:0042987; GO:0043005; GO:0043066; GO:0045121; GO:0047496 0 0 0 PF02487; Q2NKS3 CHOYP_LOC100892637.1.1 m.49164 sp PSMG3_BOVIN 38.053 113 65 2 13 122 7 117 1.83E-17 75.5 PSMG3_BOVIN reviewed Proteasome assembly chaperone 3 PSMG3 Bos taurus (Bovine) 122 0 0 0 0 0 PF10178; Q2TBQ5 CHOYP_NEMVEDRAFT_V1G234225.1.1 m.49491 sp RL7A_BOVIN 77.311 119 27 0 3 121 101 219 1.83E-61 193 RL7A_BOVIN reviewed 60S ribosomal protein L7a RPL7A Bos taurus (Bovine) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0022625; GO:0042788; GO:0044822; GO:0070062 0 0 0 PF01248; Q32L00 CHOYP_ALKBH3.1.1 m.43708 sp ALKB3_BOVIN 52.65 283 125 3 8 283 4 284 1.83E-105 311 ALKB3_BOVIN reviewed Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 3) ALKBH3 ABH3 Bos taurus (Bovine) 286 cell proliferation [GO:0008283]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA repair [GO:0006281]; oxidative single-stranded DNA demethylation [GO:0035552] GO:0005654; GO:0005739; GO:0006281; GO:0006307; GO:0008198; GO:0008283; GO:0035552; GO:0043734; GO:0051747; GO:1990930 0 0 0 PF13532; Q3SZZ2 CHOYP_XBP1.4.4 m.63791 sp XBP1_BOVIN 38.039 255 125 7 16 244 14 261 1.83E-36 132 XBP1_BOVIN reviewed "X-box-binding protein 1 (XBP-1) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" XBP1 Bos taurus (Bovine) 261 adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein destabilization [GO:0031648]; regulation of autophagy [GO:0010506]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription from RNA polymerase II promoter [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000122; GO:0000977; GO:0000981; GO:0001047; GO:0001158; GO:0001525; GO:0001889; GO:0001934; GO:0001935; GO:0002639; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006366; GO:0006511; GO:0006990; GO:0007517; GO:0010506; GO:0010508; GO:0010832; GO:0014065; GO:0016049; GO:0030176; GO:0031017; GO:0031062; GO:0031490; GO:0031648; GO:0031670; GO:0032008; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035924; GO:0042149; GO:0042632; GO:0042993; GO:0043066; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051024; GO:0055089; GO:0055092; GO:0060612; GO:0060691; GO:0070059; GO:0071222; GO:0071230; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:1900100; GO:1900102; GO:1900103; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1990418; GO:2000347; GO:2000353; GO:2000778 0 0 0 PF07716; Q4PM12 CHOYP_RL36.1.8 m.11512 sp RL36_IXOSC 60.784 102 38 1 20 121 1 100 1.83E-38 128 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q5M7W7 CHOYP_SYPM.1.1 m.579 sp SYPM_RAT 45.514 457 219 8 11 445 1 449 1.83E-131 391 SYPM_RAT reviewed "Probable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)" Pars2 Rattus norvegicus (Rat) 475 prolyl-tRNA aminoacylation [GO:0006433] GO:0003723; GO:0004827; GO:0005524; GO:0005739; GO:0005759; GO:0006433 0 0 cd00779; PF03129;PF00587; Q5T5Y3 CHOYP_LOC100932567.1.1 m.26590 sp CAMP1_HUMAN 30.32 874 476 29 1 809 116 921 1.83E-67 256 CAMP1_HUMAN reviewed Calmodulin-regulated spectrin-associated protein 1 CAMSAP1 Homo sapiens (Human) 1602 cytoskeleton organization [GO:0007010]; neuron projection development [GO:0031175]; regulation of cell morphogenesis [GO:0022604] GO:0005516; GO:0005737; GO:0005874; GO:0007010; GO:0008017; GO:0022604; GO:0030507; GO:0031175 0 0 0 PF17095;PF11971;PF08683; Q6AY40 CHOYP_LOC100375791.1.1 m.18116 sp JMJD8_RAT 54.406 261 114 2 14 271 33 291 1.83E-104 308 JMJD8_RAT reviewed JmjC domain-containing protein 8 (Jumonji domain-containing protein 8) Jmjd8 Rattus norvegicus (Rat) 291 0 0 0 0 0 0 Q6MG82 CHOYP_PRRT1.1.5 m.21697 sp PRRT1_RAT 48.718 78 40 0 192 269 217 294 1.83E-20 92 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6P0C6 CHOYP_BRAFLDRAFT_92907.1.2 m.189 sp LHPL2_DANRE 41.525 236 124 6 1 233 1 225 1.83E-52 172 LHPL2_DANRE reviewed Lipoma HMGIC fusion partner-like 2 protein lhfpl2 zgc:77456 Danio rerio (Zebrafish) (Brachydanio rerio) 225 0 GO:0016021 0 0 0 PF10242; Q6P2X9 CHOYP_MOT9.1.1 m.55775 sp MOT12_XENTR 26.19 462 288 10 1 457 18 431 1.83E-43 162 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6YHK3 CHOYP_TRIADDRAFT_55768.1.2 m.4472 sp CD109_HUMAN 33.333 321 166 6 3 320 527 802 1.83E-47 175 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q6YP21 CHOYP_KAT3.1.1 m.49207 sp KAT3_HUMAN 53.642 453 200 6 16 464 7 453 1.83E-174 500 KAT3_HUMAN reviewed Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) KYAT3 CCBL2 KAT3 Homo sapiens (Human) 454 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; cellular amino acid metabolic process [GO:0006520]; kynurenine metabolic process [GO:0070189] GO:0005739; GO:0006103; GO:0006520; GO:0009058; GO:0016212; GO:0030170; GO:0044822; GO:0047315; GO:0047804; GO:0070189 0 0 0 PF00155; Q7TPQ3 CHOYP_SHPRH.2.3 m.7526 sp SHPRH_MOUSE 46.875 128 64 1 269 396 267 390 1.83E-24 112 SHPRH_MOUSE reviewed "E3 ubiquitin-protein ligase SHPRH (EC 3.6.4.-) (EC 6.3.2.-) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)" Shprh Mus musculus (Mouse) 1674 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0000786; GO:0003677; GO:0004386; GO:0004842; GO:0005524; GO:0005634; GO:0006281; GO:0006334; GO:0006974; GO:0008270; GO:0016874; GO:0031625 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00271;PF00538;PF00176; Q80TE0 CHOYP_RPAP1.3.4 m.49644 sp RPAP1_MOUSE 31.298 131 85 2 6 136 1037 1162 1.83E-10 60.8 RPAP1_MOUSE reviewed RNA polymerase II-associated protein 1 Rpap1 Kiaa1403 Mus musculus (Mouse) 1409 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0006366; GO:0030880 0 0 0 PF08620;PF08621; Q8MQW8 CHOYP_LOC657959.1.1 m.56460 sp SPRI_DROME 46.524 374 192 3 981 1353 1418 1784 1.83E-96 346 SPRI_DROME reviewed Protein sprint (SH2 poly-proline-containing Ras-interactor protein) spri CG33175 CG34414 Drosophila melanogaster (Fruit fly) 1789 axon extension [GO:0048675]; border follicle cell migration [GO:0007298]; endocytosis [GO:0006897]; regulation of Rab protein signal transduction [GO:0032483]; signal transduction [GO:0007165] GO:0005085; GO:0005096; GO:0005938; GO:0006897; GO:0007165; GO:0007298; GO:0017016; GO:0017112; GO:0019901; GO:0030139; GO:0030971; GO:0032483; GO:0048675 0 0 0 PF00788;PF00017;PF02204; Q8N0W4 CHOYP_NLGN2.3.3 m.57354 sp NLGNX_HUMAN 31.711 596 325 22 3 536 24 599 1.83E-79 270 NLGNX_HUMAN reviewed "Neuroligin-4, X-linked (Neuroligin X) (HNLX)" NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 Homo sapiens (Human) 816 adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; learning [GO:0007612]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625] GO:0003360; GO:0004872; GO:0005886; GO:0005887; GO:0007158; GO:0007612; GO:0009986; GO:0014069; GO:0016021; GO:0021549; GO:0030054; GO:0030182; GO:0030425; GO:0030534; GO:0031404; GO:0035176; GO:0035265; GO:0042043; GO:0042803; GO:0045202; GO:0045211; GO:0045216; GO:0050808; GO:0050839; GO:0052689; GO:0060076; GO:0071625; GO:0090394; GO:0097105; GO:0097110 0 0 0 PF00135; Q924H7 CHOYP_LOC100376003.1.1 m.51910 sp WAC_MOUSE 28.737 689 376 30 1 624 1 639 1.83E-41 162 WAC_MOUSE reviewed WW domain-containing adapter protein with coiled-coil Wac Kiaa1844 Mus musculus (Mouse) 646 "cellular response to DNA damage stimulus [GO:0006974]; G1 DNA damage checkpoint [GO:0044783]; histone H2B conserved C-terminal lysine ubiquitination [GO:0071894]; histone monoubiquitination [GO:0010390]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000993; GO:0003682; GO:0005654; GO:0005681; GO:0006351; GO:0006974; GO:0010390; GO:0016239; GO:0016607; GO:0032435; GO:0044783; GO:0045893; GO:0071894 0 0 0 PF00397; Q96MM6 CHOYP_BRAFLDRAFT_208293.14.20 m.61519 sp HS12B_HUMAN 31.202 391 196 12 78 420 56 421 1.83E-48 178 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208293.19.20 m.65909 sp HS12B_HUMAN 32.464 345 180 9 11 303 61 404 1.83E-46 170 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BRJ6 CHOYP_LOC100186970.1.1 m.45226 sp CG050_HUMAN 37.931 145 76 2 121 251 50 194 1.83E-28 110 CG050_HUMAN reviewed Uncharacterized protein C7orf50 C7orf50 FP15621 Homo sapiens (Human) 194 0 GO:0044822 0 0 0 PF10180; Q9BYB0 CHOYP_LOC100366763.1.1 m.53708 sp SHAN3_HUMAN 48.843 432 206 5 63 487 8 431 1.83E-119 420 SHAN3_HUMAN reviewed SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) SHANK3 KIAA1650 PROSAP2 PSAP2 Homo sapiens (Human) 1731 "adult behavior [GO:0030534]; AMPA glutamate receptor clustering [GO:0097113]; brain morphogenesis [GO:0048854]; dendritic spine morphogenesis [GO:0060997]; guanylate kinase-associated protein clustering [GO:0097117]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of cell volume [GO:0045794]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000969]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density assembly [GO:0097107]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; social behavior [GO:0035176]; striatal medium spiny neuron differentiation [GO:0021773]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]; vocal learning [GO:0042297]" GO:0000165; GO:0005737; GO:0005886; GO:0007416; GO:0007612; GO:0007613; GO:0008022; GO:0008270; GO:0014069; GO:0017124; GO:0021773; GO:0030054; GO:0030160; GO:0030534; GO:0032232; GO:0035176; GO:0035255; GO:0042297; GO:0042802; GO:0043005; GO:0043197; GO:0044309; GO:0045211; GO:0045794; GO:0048170; GO:0048854; GO:0051835; GO:0051968; GO:0060170; GO:0060997; GO:0060999; GO:0061001; GO:0071625; GO:0097107; GO:0097110; GO:0097113; GO:0097114; GO:0097117; GO:1900271; GO:1900273; GO:1900451; GO:1900452; GO:2000463; GO:2000969 0 0 0 PF12796;PF16511;PF00595;PF00536;PF07653; Q9CZJ2 CHOYP_HSPA12A.24.27 m.64114 sp HS12B_MOUSE 34.539 304 192 5 3 303 335 634 1.83E-53 188 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9CZR2 CHOYP_NALD2.1.1 m.1189 sp NALD2_MOUSE 32.852 761 456 17 46 779 8 740 1.83E-120 382 NALD2_MOUSE reviewed N-acetylated-alpha-linked acidic dipeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase III) (GCPIII) (N-acetylaspartylglutamate peptidase II) (NAAG-peptidase II) (N-acetylated-alpha-linked acidic dipeptidase II) (NAALADase II) Naalad2 Mus musculus (Mouse) 740 neurotransmitter catabolic process [GO:0042135]; proteolysis [GO:0006508] GO:0004180; GO:0005886; GO:0006508; GO:0008233; GO:0008237; GO:0016021; GO:0016805; GO:0042135; GO:0046872; GO:0050129 0 0 0 PF02225;PF04389;PF04253; Q9D3W4 CHOYP_GPN3.2.2 m.25835 sp GPN3_MOUSE 52.852 263 67 3 1 207 1 262 1.83E-89 268 GPN3_MOUSE reviewed GPN-loop GTPase 3 (ATP-binding domain 1 family member C) Gpn3 Atpbd1c D5Ertd708e Mus musculus (Mouse) 284 0 GO:0005525; GO:0016787; GO:0043234 0 0 0 PF03029; Q9DF36 CHOYP_LOC100542017.1.1 m.15776 sp DD21B_XENLA 39.362 188 109 2 38 225 587 769 1.83E-27 112 DD21B_XENLA reviewed Nucleolar RNA helicase 2-B (EC 3.6.4.13) (DEAD box protein 21-B) (Gu-alpha-B) (Nucleolar RNA helicase Gu-B) (xGu-2) (Nucleolar RNA helicase II-B) (RH II/Gu-B) ddx21-b ddx21 Xenopus laevis (African clawed frog) 800 rRNA processing [GO:0006364]; transcription from RNA polymerase II promoter [GO:0006366] GO:0004004; GO:0005524; GO:0005654; GO:0005730; GO:0006364; GO:0006366; GO:0019843; GO:0030515; GO:0097322 0 0 0 PF00270;PF08152;PF00271; Q9ERD9 CHOYP_PRP31.4.6 m.40546 sp I23O1_RAT 39.548 177 106 1 55 231 72 247 1.83E-35 132 I23O1_RAT reviewed "Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)" Ido1 Ido Indo Rattus norvegicus (Rat) 407 immune system process [GO:0002376]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0002376; GO:0005829; GO:0016597; GO:0019441; GO:0019825; GO:0020037; GO:0033754; GO:0046872 0 0 0 PF01231; Q9ESN6 CHOYP_BRAFLDRAFT_79377.28.30 m.60205 sp TRIM2_MOUSE 27.228 202 117 7 201 388 536 721 1.83E-10 66.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_contig_028534 m.32466 sp TRIM2_MOUSE 27.119 177 117 6 182 354 534 702 1.83E-06 53.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9SLN5 CHOYP_AGAP_AGAP007120.1.1 m.57544 sp MAP1A_ARATH 62.791 86 32 0 1 86 150 235 1.83E-32 119 MAP1A_ARATH reviewed Methionine aminopeptidase 1A (MAP 1A) (MetAP 1A) (EC 3.4.11.18) (Peptidase M 1A) MAP1A At2g45240 F4L23.25 Arabidopsis thaliana (Mouse-ear cress) 398 N-terminal protein amino acid modification [GO:0031365]; protein initiator methionine removal [GO:0070084]; protein processing [GO:0016485] GO:0005737; GO:0005829; GO:0016485; GO:0022626; GO:0031365; GO:0046872; GO:0070006; GO:0070084 0 0 cd01086; PF00557;PF15801; Q9Y2I8 CHOYP_WDR37.1.1 m.57561 sp WDR37_HUMAN 53.83 470 204 7 16 480 26 487 1.83E-175 504 WDR37_HUMAN reviewed WD repeat-containing protein 37 WDR37 KIAA0982 Homo sapiens (Human) 494 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0030687; GO:0070545 0 0 0 PF00400; Q9Y5Z4 CHOYP_MICPUN_58704.1.1 m.54967 sp HEBP2_HUMAN 38.65 163 97 3 56 216 38 199 1.83E-33 122 HEBP2_HUMAN reviewed Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) HEBP2 C6orf34 SOUL Homo sapiens (Human) 205 negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of necrotic cell death [GO:0010940] GO:0005737; GO:0005739; GO:0010917; GO:0010940; GO:0035794; GO:0070062 0 0 0 PF04832; A7Z035 CHOYP_EPN4.2.3 m.66030 sp EPN4_BOVIN 45.38 487 192 19 1 447 4 456 1.84E-101 327 EPN4_BOVIN reviewed Clathrin interactor 1 (Epsin-4) CLINT1 EPN4 Bos taurus (Bovine) 643 endocytosis [GO:0006897] GO:0005654; GO:0005798; GO:0005802; GO:0006897; GO:0008289; GO:0016020; GO:0030136; GO:0048471 0 0 0 PF01417; B2RXR6 CHOYP_LOC583072.20.25 m.54899 sp ANR44_MOUSE 22.778 1080 640 30 984 2002 3 949 1.84E-36 155 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; B2RXR6 CHOYP_TNKS1.5.5 m.50152 sp ANR44_MOUSE 23.798 416 241 12 18 426 12 358 1.84E-18 92 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; O14867 CHOYP_LOC100575377.5.10 m.28913 sp BACH1_HUMAN 28.205 117 84 0 7 123 11 127 1.84E-09 64.7 BACH1_HUMAN reviewed Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) 736 "DNA repair [GO:0006281]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]" GO:0000083; GO:0000117; GO:0000122; GO:0000980; GO:0001078; GO:0001205; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006281; GO:0006355; GO:0016567; GO:0020037; GO:0031463; GO:0061418 0 0 0 PF00651;PF03131; O31463 CHOYP_BRAFLDRAFT_114091.3.3 m.66866 sp HMT_BACSU 42.458 179 95 3 1 178 135 306 1.84E-39 139 HMT_BACSU reviewed Homocysteine S-methyltransferase YbgG (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase) ybgG BSU02410 Bacillus subtilis (strain 168) 315 methionine biosynthetic process [GO:0009086] GO:0008168; GO:0009086; GO:0046872 0 0 0 PF02574; O43301 CHOYP_BRAFLDRAFT_208197.15.21 m.52599 sp HS12A_HUMAN 33.447 586 334 11 4 542 50 626 1.84E-98 315 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75467 CHOYP_BRAFLDRAFT_240910.1.1 m.22828 sp Z324A_HUMAN 37.719 114 64 4 150 259 309 419 1.84E-12 71.2 Z324A_HUMAN reviewed Zinc finger protein 324A (Zinc finger protein ZF5128) ZNF324 ZNF324A Homo sapiens (Human) 553 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; P10088 CHOYP_LOC100373488.1.1 m.10129 sp TFDA_CUPPJ 25.391 256 162 9 35 265 12 263 1.84E-14 75.5 TFDA_CUPPJ reviewed "Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase (2,4-D dioxygenase) (EC 1.14.11.-)" tfdA Reut_D6479 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)) 287 "2,4-dichlorophenoxyacetic acid catabolic process [GO:0046300]; aromatic compound catabolic process [GO:0019439]" GO:0019439; GO:0031418; GO:0046300; GO:0046872; GO:0051213 "PATHWAY: Xenobiotic degradation; (2,4-dichlorophenoxy)acetate degradation." 0 0 PF02668; P16157 CHOYP_AFUA_1G01020.43.50 m.61400 sp ANK1_HUMAN 39.688 320 191 2 1 319 223 541 1.84E-55 197 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20273 CHOYP_LOC100370299.1.2 m.39527 sp CD22_HUMAN 24.625 467 304 17 40 479 148 593 1.84E-21 102 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P21783 CHOYP_AGAP_AGAP002739.4.5 m.55695 sp NOTC1_XENLA 32.846 752 433 26 2537 3265 444 1146 1.84E-89 332 NOTC1_XENLA reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (xOTCH) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 xotch Xenopus laevis (African clawed frog) 2524 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001525; GO:0004872; GO:0005509; GO:0005654; GO:0005886; GO:0006351; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P24392 CHOYP_PEX2.1.2 m.8424 sp PEX2_RAT 41.115 287 159 4 22 302 15 297 1.84E-71 226 PEX2_RAT reviewed Peroxisome biogenesis factor 2 (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) Pex2 Paf1 Pmp35 Pxmp3 Rattus norvegicus (Rat) 305 fatty acid beta-oxidation [GO:0006635]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein destabilization [GO:0031648]; protein import into peroxisome matrix [GO:0016558]; very long-chain fatty acid metabolic process [GO:0000038] GO:0000038; GO:0000122; GO:0005777; GO:0005778; GO:0005779; GO:0006635; GO:0008270; GO:0016020; GO:0016558; GO:0016593; GO:0031648; GO:0048147; GO:0050680 0 0 0 PF04757;PF00097; P31674 CHOYP_ISCW_ISCW016148.3.6 m.54385 sp RS15_ORYSJ 76.821 151 32 2 1 148 1 151 1.84E-80 237 RS15_ORYSJ reviewed 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) 154 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00203; P43143 CHOYP_LOC100374057.1.1 m.59158 sp ACHA6_RAT 28.354 328 224 4 9 327 16 341 1.84E-46 169 ACHA6_RAT reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) 493 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of dopamine secretion [GO:0033603]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0033603; GO:0035094; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; P51645 CHOYP_ARF4.2.2 m.25199 sp ARF6_XENLA 29.221 154 92 5 30 176 11 154 1.84E-12 65.9 ARF6_XENLA reviewed ADP-ribosylation factor 6 arf6 Xenopus laevis (African clawed frog) 175 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005768; GO:0005794; GO:0005886; GO:0007264; GO:0007399; GO:0010008; GO:0015031; GO:0016192; GO:0030139; GO:0030154; GO:0031527 0 0 0 PF00025; P51910 CHOYP_BRAFLDRAFT_125106.1.1 m.26757 sp APOD_MOUSE 39.344 183 109 2 17 199 5 185 1.84E-39 136 APOD_MOUSE reviewed Apolipoprotein D (Apo-D) (ApoD) Apod Mus musculus (Mouse) 189 aging [GO:0007568]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246] GO:0000302; GO:0005215; GO:0005615; GO:0005622; GO:0005783; GO:0006006; GO:0006629; GO:0007420; GO:0007568; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0042493; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405 0 0 0 PF08212; P59222 CHOYP_PEAR1.1.16 m.1170 sp SREC2_MOUSE 42.446 139 71 6 2 136 261 394 1.84E-20 94 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P62890 CHOYP_DC1I2.2.3 m.54051 sp RL30_RAT 82.301 113 20 0 1 113 1 113 1.84E-66 199 RL30_RAT reviewed 60S ribosomal protein L30 Rpl30 Rattus norvegicus (Rat) 115 liver regeneration [GO:0097421]; positive regulation of selenocysteine incorporation [GO:1904571]; selenocysteine metabolic process [GO:0016259]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005829; GO:0005840; GO:0005925; GO:0006412; GO:0016020; GO:0016259; GO:0022625; GO:0035368; GO:0070062; GO:0097421; GO:1904571 0 0 0 PF01248; P62890 CHOYP_LOC659206.3.6 m.21377 sp RL30_RAT 82.301 113 20 0 1 113 1 113 1.84E-66 199 RL30_RAT reviewed 60S ribosomal protein L30 Rpl30 Rattus norvegicus (Rat) 115 liver regeneration [GO:0097421]; positive regulation of selenocysteine incorporation [GO:1904571]; selenocysteine metabolic process [GO:0016259]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005829; GO:0005840; GO:0005925; GO:0006412; GO:0016020; GO:0016259; GO:0022625; GO:0035368; GO:0070062; GO:0097421; GO:1904571 0 0 0 PF01248; P80856 CHOYP_FABP2.1.2 m.5800 sp FABPL_RHASA 29.197 137 84 3 45 181 3 126 1.84E-10 58.9 FABPL_RHASA reviewed "Fatty acid-binding protein, liver (Fatty acid-binding protein 1) (Liver basic FABP) (LB-FABP) (Liver-type fatty acid-binding protein) (L-FABP)" fabp1 Rhamdia sapo (South American catfish) 126 0 GO:0005215; GO:0005504; GO:0005737 0 0 0 0 P82458 CHOYP_BRAFLDRAFT_86868.2.2 m.36347 sp TRI18_RAT 22.684 313 196 10 21 299 9 309 1.84E-11 68.6 TRI18_RAT reviewed E3 ubiquitin-protein ligase Midline-1 (EC 6.3.2.-) (RING finger protein Midline-1) (Tripartite motif-containing protein 18) Mid1 Fxy Trim18 Rattus norvegicus (Rat) 667 negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to microtubule [GO:0035372] GO:0005881; GO:0007026; GO:0008270; GO:0016874; GO:0032874; GO:0035372 0 0 0 PF00041;PF13765;PF00622;PF00643;PF13445; P91679 CHOYP_BRAFLDRAFT_104097.1.1 m.60572 sp PEPT1_DROME 49.08 163 75 2 14 173 3 160 1.84E-45 162 PEPT1_DROME reviewed Peptide transporter family 1 (Oligopeptide transporter 1) (Protein YIN) yin opt1 CG44402 Drosophila melanogaster (Fruit fly) 743 oligopeptide transport [GO:0006857]; protein transport [GO:0015031] GO:0005427; GO:0005887; GO:0006857; GO:0015031 0 0 cd06174; PF00854; Q04786 CHOYP_NEMVEDRAFT_V1G201552.6.6 m.64591 sp HEX_VIBVL 34.452 894 465 30 104 935 10 844 1.84E-145 456 HEX_VIBVL reviewed Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus 847 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; Q13263 CHOYP_BRAFLDRAFT_75787.4.5 m.44118 sp TIF1B_HUMAN 26.573 143 100 2 14 151 153 295 1.84E-10 62 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q13426 CHOYP_LOC100366536.3.3 m.51739 sp XRCC4_HUMAN 23.478 345 246 6 5 344 5 336 1.84E-19 91.3 XRCC4_HUMAN reviewed DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4) XRCC4 Homo sapiens (Human) 336 cellular response to lithium ion [GO:0071285]; DNA ligation involved in DNA repair [GO:0051103]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; positive regulation of ligase activity [GO:0051351]; protein sumoylation [GO:0016925]; response to X-ray [GO:0010165] GO:0005634; GO:0005654; GO:0005813; GO:0005829; GO:0005958; GO:0006302; GO:0006303; GO:0006310; GO:0008022; GO:0010165; GO:0016925; GO:0030054; GO:0032807; GO:0051103; GO:0051351; GO:0070419; GO:0071285; GO:0075713 0 0 0 PF06632; Q15125 CHOYP_LOC100371931.1.1 m.48859 sp EBP_HUMAN 40.385 104 59 1 9 109 9 112 1.84E-24 99 EBP_HUMAN reviewed "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)" EBP Homo sapiens (Human) 230 cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; cholesterol metabolic process [GO:0008203]; hemopoiesis [GO:0030097]; skeletal system development [GO:0001501] GO:0000247; GO:0001501; GO:0004769; GO:0004888; GO:0005635; GO:0005783; GO:0005789; GO:0005887; GO:0006695; GO:0008203; GO:0015238; GO:0016023; GO:0030097; GO:0033489; GO:0033490; GO:0047750 "PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}." 0 0 PF05241; Q1HG43 CHOYP_LOC100367809.2.2 m.44174 sp DOXA1_HUMAN 32.059 340 208 7 18 347 10 336 1.84E-43 158 DOXA1_HUMAN reviewed Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) 343 hydrogen peroxide metabolic process [GO:0042743]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609] GO:0005789; GO:0005886; GO:0015031; GO:0016020; GO:0016021; GO:0042743; GO:0045666; GO:0050727; GO:2000379; GO:2000609 0 0 0 PF10204; Q1RMG8 CHOYP_LOC100200424.1.1 m.16669 sp RPAC2_BOVIN 56.757 111 46 2 5 114 20 129 1.84E-40 134 RPAC2_BOVIN reviewed DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (DNA-directed RNA polymerase I subunit D) POLR1D Bos taurus (Bovine) 133 transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase I promoter [GO:0006360] GO:0003677; GO:0003899; GO:0005666; GO:0005736; GO:0006360; GO:0006383 0 0 0 0 Q28298 CHOYP_LOC100369294.1.6 m.5559 sp RRBP1_CANLF 25.818 825 455 29 217 967 785 1526 1.84E-19 98.6 RRBP1_CANLF reviewed Ribosome-binding protein 1 (180 kDa ribosome receptor) (RRp) RRBP1 P180 Canis lupus familiaris (Dog) (Canis familiaris) 1534 protein transport [GO:0015031]; signal transduction [GO:0007165]; translation [GO:0006412] GO:0004872; GO:0005840; GO:0006412; GO:0007165; GO:0015031; GO:0030176 0 0 0 PF05104; Q3TYE7 CHOYP_TM136.1.1 m.7418 sp TM136_MOUSE 47.788 226 115 2 15 239 16 239 1.84E-65 207 TM136_MOUSE reviewed Transmembrane protein 136 Tmem136 Gm184 Mus musculus (Mouse) 245 0 GO:0016021 0 0 0 PF03798; Q3ZBL4 CHOYP_BRAFLDRAFT_268354.1.1 m.57510 sp LZTL1_BOVIN 49.505 303 143 5 1 297 1 299 1.84E-91 276 LZTL1_BOVIN reviewed Leucine zipper transcription factor-like protein 1 LZTFL1 Bos taurus (Bovine) 299 0 GO:0005737 0 0 0 0 Q5JXM2 CHOYP_LOC100373794.1.5 m.10503 sp MET24_HUMAN 25.63 238 144 10 335 542 131 365 1.84E-11 69.3 MET24_HUMAN reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) METTL24 C6orf186 Homo sapiens (Human) 366 0 GO:0005576; GO:0008168 0 0 0 PF13383; Q5ZMS6 CHOYP_TDRD3.2.2 m.8520 sp TDRD3_CHICK 41.045 402 182 8 5 368 7 391 1.84E-79 274 TDRD3_CHICK reviewed Tudor domain-containing protein 3 TDRD3 RCJMB04_1e24 Gallus gallus (Chicken) 741 covalent chromatin modification [GO:0016569]; mRNA processing [GO:0006397] GO:0003682; GO:0003713; GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0016569; GO:0035064 0 0 0 PF08585;PF06003;PF00627; Q66S13 CHOYP_DPSE_GA24742.1.2 m.54989 sp NATT4_THANI 30.714 140 82 6 4 141 78 204 1.84E-07 52.4 NATT4_THANI reviewed Natterin-4 (EC 3.4.-.-) 0 Thalassophryne nattereri (Niquim) 387 0 GO:0005576; GO:0016787 0 0 0 PF11901; Q6AYN9 CHOYP_BRAFLDRAFT_132233.2.4 m.18349 sp CC181_RAT 23.023 430 225 11 111 498 143 508 1.84E-13 76.3 CC181_RAT reviewed Coiled-coil domain-containing protein 181 Ccdc181 Rattus norvegicus (Rat) 509 0 GO:0005654 0 0 0 0 Q6P1C6 CHOYP_BRAFLDRAFT_103548.1.1 m.4842 sp LRIG3_MOUSE 29.71 138 90 3 1 137 406 537 1.84E-11 64.3 LRIG3_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) Lrig3 Kiaa3016 Mus musculus (Mouse) 1117 otolith morphogenesis [GO:0032474] GO:0005615; GO:0005886; GO:0016021; GO:0030659; GO:0032474 0 0 0 PF07679;PF13855; Q6P2D8 CHOYP_LOC584905.1.1 m.51595 sp XRRA1_HUMAN 39.576 283 139 5 23 295 15 275 1.84E-56 212 XRRA1_HUMAN reviewed X-ray radiation resistance-associated protein 1 XRRA1 Homo sapiens (Human) 792 response to X-ray [GO:0010165] GO:0005634; GO:0005737; GO:0010165 0 0 0 0 Q6P2X9 CHOYP_LOC100374495.1.1 m.55367 sp MOT12_XENTR 29.275 345 214 6 1 319 88 428 1.84E-39 149 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6PFY8 CHOYP_contig_030676 m.34953 sp TRI45_MOUSE 29.008 131 73 4 10 125 131 256 1.84E-08 54.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q710D6 CHOYP_COX5B.1.3 m.20245 sp COX5B_VULVU 33.036 112 71 3 227 336 12 121 1.84E-13 69.7 COX5B_VULVU reviewed "Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) (Sperm protein 8) (fSP8)" COX5B SP8 Vulpes vulpes (Red fox) 128 0 GO:0004129; GO:0005743; GO:0046872 0 0 cd00924; PF01215; Q86Z23 CHOYP_C1QL4L.3.7 m.5968 sp C1QL4_HUMAN 36.429 140 70 7 24 156 110 237 1.84E-17 79.7 C1QL4_HUMAN reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8BNA6 CHOYP_NEMVEDRAFT_V1G20161.1.1 m.20254 sp FAT3_MOUSE 28.114 281 182 8 6 270 1507 1783 1.84E-20 100 FAT3_MOUSE reviewed Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) 4555 cell morphogenesis involved in differentiation [GO:0000904]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764]; retina layer formation [GO:0010842] GO:0000904; GO:0001764; GO:0005509; GO:0005886; GO:0007156; GO:0010842; GO:0016021; GO:0030425; GO:2000171 0 0 0 PF00028;PF02210; Q8K4S1 CHOYP_LOC100870548.1.1 m.14349 sp PLCE1_MOUSE 39.236 576 275 13 68 613 1622 2152 1.84E-113 377 PLCE1_MOUSE reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" Plce1 Kiaa1516 Plce Mus musculus (Mouse) 2282 activation of MAPK activity [GO:0000187]; glomerulus development [GO:0032835]; lipid catabolic process [GO:0016042]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; Ras protein signal transduction [GO:0007265]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; regulation of protein kinase activity [GO:0045859]; regulation of Ras protein signal transduction [GO:0046578] GO:0000139; GO:0000187; GO:0004435; GO:0004629; GO:0004871; GO:0005085; GO:0005737; GO:0005829; GO:0005886; GO:0007200; GO:0007265; GO:0008277; GO:0016042; GO:0019899; GO:0032835; GO:0045859; GO:0046578 0 0 0 PF00168;PF00388;PF00387;PF00788;PF00617; Q90YS3 CHOYP_RS2.5.10 m.29939 sp RS2_ICTPU 78.906 128 26 1 8 134 135 262 1.84E-68 211 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q96GD3 CHOYP_SCMH1.1.1 m.1166 sp SCMH1_HUMAN 43.171 637 276 12 18 571 26 659 1.84E-162 481 SCMH1_HUMAN reviewed Polycomb protein SCMH1 (Sex comb on midleg homolog 1) SCMH1 Homo sapiens (Human) 660 "anatomical structure morphogenesis [GO:0009653]; anterior/posterior pattern specification [GO:0009952]; chromatin remodeling [GO:0006338]; gene silencing [GO:0016458]; negative regulation of transcription, DNA-templated [GO:0045892]; protein sumoylation [GO:0016925]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0006338; GO:0006351; GO:0007283; GO:0009653; GO:0009952; GO:0010369; GO:0016458; GO:0016925; GO:0045892 0 0 0 PF02820;PF00536;PF12140; Q9V4M2 CHOYP_BRAFLDRAFT_71598.1.10 m.8484 sp WECH_DROME 32.941 85 54 1 90 171 540 624 1.84E-07 54.7 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; Q9Y2C3 CHOYP_LOC100373563.1.1 m.35067 sp B3GT5_HUMAN 33.456 272 168 8 60 324 43 308 1.84E-38 142 B3GT5_HUMAN reviewed "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5)" B3GALT5 Homo sapiens (Human) 310 protein glycosylation [GO:0006486] GO:0000139; GO:0005783; GO:0005794; GO:0006486; GO:0008499; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9Y394 CHOYP_BRAFLDRAFT_216841.2.4 m.42282 sp DHRS7_HUMAN 48.986 296 148 3 27 320 29 323 1.84E-91 279 DHRS7_HUMAN reviewed Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) 339 0 GO:0016020; GO:0016491 0 0 0 PF00106; A4FU69 CHOYP_LOC100651687.1.1 m.39885 sp EFCB5_HUMAN 32.599 227 147 2 1 227 218 438 1.85E-37 142 EFCB5_HUMAN reviewed EF-hand calcium-binding domain-containing protein 5 EFCAB5 Homo sapiens (Human) 1503 0 GO:0005509 0 0 0 0 A4IF63 CHOYP_TRIM2.27.59 m.34736 sp TRIM2_BOVIN 27.206 136 86 2 25 147 552 687 1.85E-09 58.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B1A8Z2 CHOYP_NEMVEDRAFT_V1G160342.1.1 m.3115 sp CIB1_SHEEP 40.93 215 100 3 1 212 1 191 1.85E-47 157 CIB1_SHEEP reviewed Calcium and integrin-binding protein 1 (Calmyrin) CIB1 Ovis aries (Sheep) 191 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell division [GO:0051301]; integrin-mediated signaling pathway [GO:0007229]; spermatogenesis [GO:0007283] GO:0001525; GO:0005509; GO:0005634; GO:0005815; GO:0006915; GO:0007049; GO:0007155; GO:0007229; GO:0007283; GO:0016324; GO:0030027; GO:0030154; GO:0030426; GO:0032433; GO:0032587; GO:0042383; GO:0048471; GO:0051301 0 0 0 PF13499; D2GXS7 CHOYP_BRAFLDRAFT_84666.2.3 m.31336 sp TRIM2_AILME 27.778 180 123 5 213 390 533 707 1.85E-06 53.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O61491 CHOYP_FLOT1.1.2 m.21435 sp FLOT1_DROME 72.193 187 52 0 2 188 4 190 1.85E-95 293 FLOT1_DROME reviewed Flotillin-1 Flo1 Flo Flo-1 FLODM-1 CG8200 Drosophila melanogaster (Fruit fly) 426 multicellular organism development [GO:0007275] GO:0005198; GO:0005737; GO:0005886; GO:0007275; GO:0016600 0 0 0 PF01145;PF15975; O70277 CHOYP_BRAFLDRAFT_71754.1.3 m.27357 sp TRIM3_RAT 28.333 120 82 3 42 158 625 743 1.85E-08 56.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70401 CHOYP_DVIR_GJ13079.1.1 m.42030 sp TSN6_MOUSE 24.904 261 155 6 12 271 21 241 1.85E-15 77 TSN6_MOUSE reviewed Tetraspanin-6 (Tspan-6) (Transmembrane 4 superfamily member 6) Tspan6 Tm4sf6 Mus musculus (Mouse) 245 cell surface receptor signaling pathway [GO:0007166]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005887; GO:0007166; GO:0039532; GO:0043123; GO:0070062; GO:1901223 0 0 0 PF00335; O95243 CHOYP_BRAFLDRAFT_119982.1.1 m.62398 sp MBD4_HUMAN 71.329 143 41 0 676 818 437 579 1.85E-71 248 MBD4_HUMAN reviewed Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) MBD4 MED1 Homo sapiens (Human) 580 depyrimidination [GO:0045008]; DNA repair [GO:0006281]; response to estradiol [GO:0032355]; response to radiation [GO:0009314] GO:0000785; GO:0003696; GO:0004520; GO:0005634; GO:0005654; GO:0006281; GO:0008263; GO:0009314; GO:0019104; GO:0032355; GO:0045008 0 0 0 PF01429; P04113 CHOYP_LOC100893889.2.2 m.64935 sp MLRA_MIZYE 72.671 161 44 0 6 166 1 161 1.85E-80 238 MLRA_MIZYE reviewed "Myosin regulatory light chain A, smooth adductor muscle" 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 161 0 GO:0005509; GO:0016459 0 0 0 PF13405; P04113 CHOYP_TBA1.8.9 m.61528 sp MLRA_MIZYE 72.671 161 44 0 6 166 1 161 1.85E-80 238 MLRA_MIZYE reviewed "Myosin regulatory light chain A, smooth adductor muscle" 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 161 0 GO:0005509; GO:0016459 0 0 0 PF13405; P04988 CHOYP_BRAFLDRAFT_77225.1.2 m.29845 sp CYSP1_DICDI 32.115 383 208 10 6 378 3 343 1.85E-58 196 CYSP1_DICDI reviewed Cysteine proteinase 1 (EC 3.4.22.-) cprA CP1 DDB_G0290957 Dictyostelium discoideum (Slime mold) 343 hyperosmotic response [GO:0006972]; proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0006972; GO:0051603 0 0 0 PF08246;PF00112; P07797 CHOYP_LOC656261.1.1 m.4949 sp FRI3_LITCT 39.394 165 99 1 43 207 5 168 1.85E-32 118 FRI3_LITCT reviewed "Ferritin, lower subunit (Ferritin L)" 0 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 173 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0005623; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P10394 CHOYP_LOC100535270.1.4 m.600 sp POL4_DROME 27.523 218 157 1 16 233 976 1192 1.85E-21 99.8 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P10758 CHOYP_CD209.6.6 m.66804 sp LITH_RAT 36.429 140 81 5 279 413 26 162 1.85E-20 90.9 LITH_RAT reviewed Lithostathine (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) Reg1 Reg Rattus norvegicus (Rat) 165 calcium ion homeostasis [GO:0055074]; cellular response to chemokine [GO:1990869]; cellular response to gastrin [GO:1990878]; liver regeneration [GO:0097421]; midgut development [GO:0007494]; negative regulation of cell proliferation [GO:0008285]; pancreas regeneration [GO:1990798]; positive regulation of acinar cell proliferation [GO:1904699]; positive regulation of dendrite extension [GO:1903861]; positive regulation of gene expression [GO:0010628]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; response to acetylsalicylate [GO:1903492]; response to gastrin [GO:1990867]; response to growth hormone-releasing hormone [GO:1990864]; response to hypoxia [GO:0001666]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to water-immersion restraint stress [GO:1990785]; wound healing [GO:0042060] GO:0001666; GO:0005102; GO:0005615; GO:0005829; GO:0007494; GO:0008083; GO:0008285; GO:0010628; GO:0014070; GO:0019902; GO:0019903; GO:0030246; GO:0030426; GO:0031667; GO:0032590; GO:0032809; GO:0042060; GO:0042588; GO:0042802; GO:0042803; GO:0043234; GO:0045178; GO:0048471; GO:0051260; GO:0051289; GO:0055074; GO:0097421; GO:1903492; GO:1903861; GO:1904692; GO:1904699; GO:1990785; GO:1990798; GO:1990864; GO:1990867; GO:1990869; GO:1990878 0 0 0 PF00059; P11137 CHOYP_UAFA.6.8 m.45002 sp MTAP2_HUMAN 43.011 186 77 6 1711 1891 1612 1773 1.85E-27 126 MTAP2_HUMAN reviewed Microtubule-associated protein 2 (MAP-2) MAP2 Homo sapiens (Human) 1827 central nervous system neuron development [GO:0021954]; dendrite morphogenesis [GO:0048813]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175] GO:0000226; GO:0001578; GO:0002162; GO:0005198; GO:0005730; GO:0005737; GO:0005874; GO:0005875; GO:0008017; GO:0021954; GO:0031175; GO:0043005; GO:0048813 0 0 0 PF08377;PF00418; P12394 CHOYP_LOC100371830.2.6 m.14921 sp CP17A_CHICK 35.011 437 279 5 40 473 38 472 1.85E-88 283 CP17A_CHICK reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Gallus gallus (Chicken) 508 hormone biosynthetic process [GO:0042446]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0008202; GO:0016020; GO:0020037; GO:0042446; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; P16157 CHOYP_LOC583072.3.25 m.17917 sp ANK1_HUMAN 25.59 848 502 31 226 1052 47 786 1.85E-39 163 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P30988 CHOYP_VIPR1.1.1 m.56342 sp CALCR_HUMAN 25.99 404 257 14 99 486 73 450 1.85E-34 139 CALCR_HUMAN reviewed Calcitonin receptor (CT-R) CALCR Homo sapiens (Human) 508 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; response to glucocorticoid [GO:0051384] GO:0004872; GO:0004948; GO:0005623; GO:0005886; GO:0005887; GO:0007166; GO:0007189; GO:0007204; GO:0008565; GO:0015031; GO:0030819; GO:0031623; GO:0032841; GO:0045762; GO:0051384; GO:0072659 0 0 0 PF00002;PF02793; P49183 CHOYP_LOC100891970.1.1 m.21453 sp DNAS1_MOUSE 43.697 238 122 4 10 240 50 282 1.85E-57 188 DNAS1_MOUSE reviewed Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) Dnase1 Dnl1 Mus musculus (Mouse) 284 apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308] GO:0004530; GO:0005634; GO:0005635; GO:0006308; GO:0006915; GO:0070062 0 0 0 0 P50607 CHOYP_TUB.1.1 m.47407 sp TUB_HUMAN 69.469 226 63 1 279 498 248 473 1.85E-117 357 TUB_HUMAN reviewed Tubby protein homolog TUB Homo sapiens (Human) 506 "phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to nonmotile primary cilium [GO:0097500]; response to hormone [GO:0009725]; retina development in camera-type eye [GO:0060041]; sensory perception of sound [GO:0007605]" GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005929; GO:0006910; GO:0007605; GO:0009725; GO:0032403; GO:0035091; GO:0045494; GO:0050766; GO:0060041; GO:0097500; GO:1903546 0 0 0 PF01167;PF16322; P54797 CHOYP_TANGO2.1.1 m.37082 sp TNG2_MOUSE 32.667 300 169 13 15 307 1 274 1.85E-39 142 TNG2_MOUSE reviewed Transport and Golgi organization 2 homolog (Ser/Thr-rich protein T10 in DGCR region) Tango2 D16H22S680E T10 Mus musculus (Mouse) 276 0 GO:0005739 0 0 0 PF05742; P86854 CHOYP_BRAFLDRAFT_201924.1.1 m.30855 sp PLCL_MYTGA 31.818 132 84 4 157 286 29 156 1.85E-14 72.8 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P97831 CHOYP_TWST2.1.1 m.814 sp TWST2_RAT 66.429 140 32 4 40 178 31 156 1.85E-54 172 TWST2_RAT reviewed Twist-related protein 2 Twist2 Rattus norvegicus (Rat) 160 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005737; GO:0006351; GO:0007275; GO:0030154; GO:0043066; GO:0045668; GO:0045892 0 0 0 PF00010; Q08420 CHOYP_contig_043877 m.50699 sp SODE_RAT 29.134 127 74 4 23 136 100 223 1.85E-08 54.3 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q0E908 CHOYP_BRAFLDRAFT_92367.3.4 m.54620 sp HIL_DROME 24.324 481 306 16 68 524 333 779 1.85E-30 134 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q0EEE2 CHOYP_LOC100372915.1.7 m.6490 sp PTHD3_MOUSE 27.855 858 566 19 8 835 70 904 1.85E-113 371 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q16QL3 CHOYP_COQ2.3.3 m.62477 sp COQ2_AEDAE 57 200 85 1 6 204 208 407 1.85E-80 249 COQ2_AEDAE reviewed "4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Coenzyme Q biosynthesis protein 2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)" coq2 AAEL011249 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 441 isoprenoid biosynthetic process [GO:0008299]; transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase I promoter [GO:0006360]; ubiquinone biosynthetic process [GO:0006744] GO:0002083; GO:0005666; GO:0005736; GO:0005743; GO:0006360; GO:0006383; GO:0006744; GO:0008299; GO:0008412; GO:0031305; GO:0047293 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03189}. 0 0 PF01040; Q1LYL8 CHOYP_ASTE1.1.1 m.58774 sp ASTE1_DANRE 26.893 647 377 18 1 617 1 581 1.85E-56 206 ASTE1_DANRE reviewed Protein asteroid homolog 1 aste1 si:dkey-11p23.5 Danio rerio (Zebrafish) (Brachydanio rerio) 692 0 0 0 0 0 0 Q2KIR7 CHOYP_LOC101065647.1.2 m.8099 sp GLYAT_BOVIN 21.786 280 198 5 14 274 13 290 1.85E-16 81.6 GLYAT_BOVIN reviewed Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1.71) GLYAT Bos taurus (Bovine) 295 glycine metabolic process [GO:0006544]; monocarboxylic acid metabolic process [GO:0032787]; response to toxic substance [GO:0009636] GO:0005739; GO:0006544; GO:0009636; GO:0032787; GO:0047961; GO:0047962 0 0 0 PF08444;PF06021; Q2WEA5 CHOYP_LOC754831.1.1 m.62252 sp TRPM1_RAT 30.673 401 252 6 1 388 865 1252 1.85E-58 212 TRPM1_RAT reviewed Transient receptor potential cation channel subfamily M member 1 (Melastatin-1) Trpm1 Rattus norvegicus (Rat) 1628 calcium ion transport into cytosol [GO:0060402]; cellular response to light stimulus [GO:0071482]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; protein tetramerization [GO:0051262] GO:0005262; GO:0005886; GO:0007216; GO:0016021; GO:0051262; GO:0060402; GO:0071482 0 0 0 PF00520;PF16519; Q32L41 CHOYP_GCHFR.1.1 m.16972 sp GFRP_BOVIN 61.905 84 32 0 19 102 1 84 1.85E-34 116 GFRP_BOVIN reviewed GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) GCHFR Bos taurus (Bovine) 84 negative regulation of biosynthetic process [GO:0009890] GO:0005829; GO:0009890; GO:0030425; GO:0031965; GO:0042470 0 0 0 PF06399; Q3V1V3 CHOYP_BRAFLDRAFT_96606.1.1 m.8509 sp ESF1_MOUSE 36.919 409 211 13 1 395 468 843 1.85E-48 179 ESF1_MOUSE reviewed ESF1 homolog (ABT1-associated protein) Esf1 Abtap Mus musculus (Mouse) 845 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005615; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0044822 0 0 0 PF08159; Q40588 CHOYP_LOC100206475.15.16 m.60757 sp ASO_TOBAC 26.884 584 321 21 155 715 50 550 1.85E-46 177 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q4PRC9 CHOYP_SL3.1.1 m.8266 sp SL4_DABSI 42.857 84 42 2 5 86 4 83 1.85E-11 60.1 SL4_DABSI reviewed Snaclec 4 (C-type lectin-like 4) 0 Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis) 146 0 GO:0005576 0 0 0 PF00059; Q502M6 CHOYP_TVAG_067900.2.7 m.914 sp ANR29_DANRE 38.22 191 117 1 95 285 56 245 1.85E-35 132 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q562D6 CHOYP_LOC100472408.1.1 m.17281 sp TRMO_MOUSE 35.083 362 161 9 49 338 31 390 1.85E-64 213 TRMO_MOUSE reviewed tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) Trmo Mus musculus (Mouse) 431 tRNA methylation [GO:0030488] GO:0003723; GO:0016430; GO:0030488 0 0 cd09281; PF01980; Q5G268 CHOYP_LOC587132.1.1 m.14060 sp NETR_NOMLE 43.175 315 165 7 24 329 280 589 1.85E-69 245 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5REG4 CHOYP_LOC101067833.1.3 m.2416 sp DTX3_PONAB 53.368 193 86 4 225 414 155 346 1.85E-67 221 DTX3_PONAB reviewed Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 347 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] GO:0005737; GO:0007219; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q60847 CHOYP_CO6A5.4.6 m.45525 sp COCA1_MOUSE 36.923 195 116 4 14 204 1185 1376 1.85E-29 126 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q61555 CHOYP_LOC100165514.1.1 m.45761 sp FBN2_MOUSE 44.8 375 178 8 1 359 1568 1929 1.85E-88 294 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q66II3 CHOYP_GRAP2.1.1 m.18050 sp GRB2_XENTR 67.308 104 27 2 1 104 55 151 1.85E-43 144 GRB2_XENTR reviewed Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) grb2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 229 insulin receptor signaling pathway [GO:0008286]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275] GO:0005154; GO:0005634; GO:0005737; GO:0005768; GO:0005794; GO:0007275; GO:0008286; GO:0043560; GO:0051321 0 0 0 PF00017;PF00018; Q6DF57 CHOYP_BRAFLDRAFT_264304.1.1 m.35625 sp GPT11_XENTR 44.106 263 138 3 20 278 4 261 1.85E-67 213 GPT11_XENTR reviewed G patch domain-containing protein 11 (Coiled-coil domain-containing protein 75) gpatch11 ccdc75 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 261 0 GO:0000776; GO:0000777; GO:0003676 0 0 0 PF13821;PF01585; Q6DIB5 CHOYP_ISCW_ISCW020553.2.2 m.45505 sp MEG10_MOUSE 38.872 337 182 16 206 540 348 662 1.85E-38 154 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6MG82 CHOYP_contig_030346 m.34537 sp PRRT1_RAT 42.466 73 42 0 82 154 221 293 1.85E-13 69.3 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6P2X9 CHOYP_LOC100882967.1.1 m.36674 sp MOT12_XENTR 28.185 259 160 8 5 259 3 239 1.85E-18 90.9 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6ZRF8 CHOYP_LOC100369754.4.10 m.32457 sp RN207_HUMAN 22.995 187 123 8 2 182 123 294 1.85E-06 51.6 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_LOC100370758.3.3 m.60880 sp RN207_HUMAN 25.837 209 132 9 16 218 103 294 1.85E-12 72.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q75WF2 CHOYP_DNA2.3.5 m.49493 sp DNA2_ACAPL 34.072 361 206 11 5 342 7 358 1.85E-57 193 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q7SY52 CHOYP_SLK.1.1 m.59382 sp STK10_DANRE 48.898 499 221 9 1 492 1 472 1.85E-145 468 STK10_DANRE reviewed Serine/threonine-protein kinase 10 (EC 2.7.11.1) stk10 zgc:63495 Danio rerio (Zebrafish) (Brachydanio rerio) 974 cell cycle [GO:0007049]; protein autophosphorylation [GO:0046777]; regulation of lymphocyte migration [GO:2000401] GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005886; GO:0007049; GO:0042803; GO:0046777; GO:2000401 0 0 0 PF00069;PF12474; Q8BHN5 CHOYP_DPSE_GA12086.2.2 m.11343 sp RBM45_MOUSE 42.342 222 120 4 18 235 22 239 1.85E-52 181 RBM45_MOUSE reviewed RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) Rbm45 Drb1 Drbp1 Mus musculus (Mouse) 476 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0007399; GO:0030154; GO:0044822 0 0 0 PF00076; Q8BLF1 CHOYP_AADACL4.1.1 m.28469 sp NCEH1_MOUSE 30.049 406 250 10 24 415 21 406 1.85E-52 183 NCEH1_MOUSE reviewed Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1) (Chlorpyrifos oxon-binding protein) (CPO-BP) Nceh1 Aadacl1 Kiaa1363 Mus musculus (Mouse) 408 lipid catabolic process [GO:0016042]; protein dephosphorylation [GO:0006470]; SMAD protein signal transduction [GO:0060395]; xenobiotic metabolic process [GO:0006805] GO:0005783; GO:0006470; GO:0006805; GO:0016020; GO:0016021; GO:0016042; GO:0017171; GO:0042301; GO:0052689; GO:0060395 0 0 0 PF07859; Q8BM88 CHOYP_ISCW_ISCW017550.1.1 m.51083 sp CATO_MOUSE 44.574 258 138 3 76 332 59 312 1.85E-71 227 CATO_MOUSE reviewed Cathepsin O (EC 3.4.22.42) Ctso Mus musculus (Mouse) 312 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0051603 0 0 0 PF00112; Q8CFD0 CHOYP_SFXN5.1.1 m.60589 sp SFXN5_RAT 66.038 318 108 0 6 323 25 342 1.85E-167 472 SFXN5_RAT reviewed Sideroflexin-5 (Tricarboxylate carrier BBG-TCC) Sfxn5 Rattus norvegicus (Rat) 342 citrate transport [GO:0015746]; iron ion homeostasis [GO:0055072] GO:0005739; GO:0005743; GO:0015137; GO:0015746; GO:0016021; GO:0055072 0 0 0 PF03820; Q8K3K9 CHOYP_LOC100616953.1.4 m.426 sp GIMA4_RAT 31.25 224 145 6 47 268 25 241 1.85E-24 103 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8TC12 CHOYP_TRIADDRAFT_18543.1.2 m.6817 sp RDH11_HUMAN 42.105 285 144 5 19 294 35 307 1.85E-61 201 RDH11_HUMAN reviewed Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1) RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82 Homo sapiens (Human) 318 adaptation of rhodopsin mediated signaling [GO:0016062]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572] GO:0001523; GO:0001917; GO:0004745; GO:0005622; GO:0005789; GO:0016021; GO:0016062; GO:0016616; GO:0042572; GO:0042574; GO:0052650 0 0 0 PF00106; Q8VCY6 CHOYP_BRAFLDRAFT_92084.1.1 m.10643 sp UTP6_MOUSE 35.809 606 356 10 1 582 1 597 1.85E-125 384 UTP6_MOUSE reviewed U3 small nucleolar RNA-associated protein 6 homolog (Multiple hat domains protein) Utp6 Mhat Mus musculus (Mouse) 597 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" GO:0000462; GO:0005730; GO:0030515; GO:0032040; GO:0034388 0 0 0 PF08640; Q8WWN9 CHOYP_LOC100748006.2.2 m.62661 sp ICEF1_HUMAN 51.351 74 36 0 305 378 32 105 1.85E-20 95.9 ICEF1_HUMAN reviewed Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) IPCEF1 KIAA0403 Homo sapiens (Human) 437 oxygen transport [GO:0015671]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005344; GO:0005737; GO:0005886; GO:0006979; GO:0015671 0 0 0 PF00169; Q91WM2 CHOYP_LOC100547770.1.1 m.48573 sp CECR5_MOUSE 49.689 161 70 3 1 158 169 321 1.85E-45 157 CECR5_MOUSE reviewed Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) 419 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q9BE18 CHOYP_NEMVEDRAFT_V1G146038.1.1 m.22454 sp MAGE1_MACFA 32.45 151 95 1 640 783 201 351 1.85E-10 68.9 MAGE1_MACFA reviewed Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (MAGE-E1 antigen) MAGEE1 QflA-10248 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 957 0 GO:0005634; GO:0005886; GO:0030425; GO:0045211; GO:0048471 0 0 0 PF01454; Q9CZJ2 CHOYP_LOC770082.4.4 m.37278 sp HS12B_MOUSE 30.168 179 117 3 8 178 507 685 1.85E-21 94 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9JIB0 CHOYP_RANGRF.2.2 m.26694 sp MOG1_MOUSE 41.341 179 100 3 8 185 9 183 1.85E-42 143 MOG1_MOUSE reviewed Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1) Rangrf Mog1 Rangnrf Mus musculus (Mouse) 185 ER to Golgi vesicle-mediated transport [GO:0006888]; nucleocytoplasmic transport [GO:0006913]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of protein localization to cell surface [GO:2000010]; protein exit from endoplasmic reticulum [GO:0032527]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649] GO:0003254; GO:0005085; GO:0005087; GO:0005634; GO:0005654; GO:0005737; GO:0005791; GO:0005901; GO:0006888; GO:0006913; GO:0008536; GO:0008565; GO:0014704; GO:0017080; GO:0032527; GO:0042391; GO:0044325; GO:0090004; GO:1902305; GO:2000010; GO:2000649 0 0 0 PF04603; Q9WV92 CHOYP_LOC100373842.3.4 m.25327 sp E41L3_MOUSE 58.824 340 134 4 4 342 120 454 1.85E-135 442 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; A0JP89 CHOYP_CS066.2.3 m.59329 sp RYDEN_XENTR 36.727 275 130 6 16 249 7 278 1.86E-48 165 RYDEN_XENTR reviewed Repressor of yield of DENV protein homolog 0 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 304 0 GO:0003723; GO:0005634; GO:0005737 0 0 0 PF15135; A4IF63 CHOYP_LOC100369333.30.32 m.60190 sp TRIM2_BOVIN 32.075 106 71 1 32 137 611 715 1.86E-09 58.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8TX70 CHOYP_LOC101064693.1.2 m.30288 sp CO6A5_HUMAN 27.009 585 392 15 28 605 437 993 1.86E-49 189 CO6A5_HUMAN reviewed Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) 2615 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; A9CPT4 CHOYP_BRAFLDRAFT_125037.2.3 m.13981 sp TDRD1_ORYLA 24.417 901 573 29 608 1419 123 1004 1.86E-48 194 TDRD1_ORYLA reviewed Tudor domain-containing protein 1 tdrd1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 1133 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0007275; GO:0007281; GO:0007283; GO:0031047; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; D3YXG0 CHOYP_LOC100119248.1.1 m.60321 sp HMCN1_MOUSE 25.159 628 400 27 6 594 665 1261 1.86E-22 107 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O35264 CHOYP_PA1B2.1.2 m.10637 sp PA1B2_RAT 52.232 224 106 1 40 263 7 229 1.86E-83 252 PA1B2_RAT reviewed Platelet-activating factor acetylhydrolase IB subunit beta (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) (Platelet-activating factor acetylhydrolase alpha 2 subunit) (PAF-AH alpha 2) Pafah1b2 Pafahb Rattus norvegicus (Rat) 229 brain development [GO:0007420]; lipid catabolic process [GO:0016042]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283] GO:0003847; GO:0005730; GO:0005829; GO:0005886; GO:0007283; GO:0007420; GO:0016042; GO:0016239; GO:0042803; GO:0046982; GO:0047179; GO:0070062 0 0 0 PF13472; O43603 CHOYP_NPFF2.1.1 m.25291 sp GALR2_HUMAN 26.087 299 201 7 4 301 23 302 1.86E-16 82.8 GALR2_HUMAN reviewed Galanin receptor type 2 (GAL2-R) (GALR-2) GALR2 GALNR2 Homo sapiens (Human) 387 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; digestion [GO:0007586]; feeding behavior [GO:0007631]; inositol phosphate metabolic process [GO:0043647]; learning or memory [GO:0007611]; multicellular organism development [GO:0007275]; muscle contraction [GO:0006936]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron projection development [GO:0031175]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of large conductance calcium-activated potassium channel activity [GO:1902608]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0004966; GO:0005829; GO:0005886; GO:0005887; GO:0006936; GO:0007166; GO:0007188; GO:0007189; GO:0007194; GO:0007200; GO:0007204; GO:0007268; GO:0007275; GO:0007586; GO:0007611; GO:0007631; GO:0016021; GO:0017046; GO:0031175; GO:0042923; GO:0043647; GO:0045944; GO:0046488; GO:1902608 0 0 0 PF00001; O61463 CHOYP_LOC100175959.7.7 m.63290 sp RLA2_CRYST 64.179 67 24 0 1 67 1 67 1.86E-24 92.4 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 P10394 CHOYP_LOC100534899.1.1 m.18465 sp POL4_DROME 27.941 272 187 4 5 272 924 1190 1.86E-28 119 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P13701 CHOYP_SYB.3.3 m.66834 sp SYB_TETCF 71.845 103 28 1 1 102 1 103 1.86E-45 146 SYB_TETCF reviewed Synaptobrevin (Synaptic vesicle-associated integral membrane protein) (VAMP-1) 0 Tetronarce californica (Pacific electric ray) (Torpedo californica) 120 vesicle-mediated transport [GO:0016192] GO:0016021; GO:0016192; GO:0030054; GO:0030672; GO:0043005 0 0 0 PF00957; P16157 CHOYP_TVAG_168010.29.45 m.54156 sp ANK1_HUMAN 34.853 373 243 0 3 375 220 592 1.86E-64 228 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20481 CHOYP_BUCC.1.2 m.10972 sp BUCC_APLCA 55.479 146 64 1 100 245 335 479 1.86E-39 148 BUCC_APLCA reviewed Buccalin [Cleaved into: Buccalin-D; Buccalin-E; Buccalin-F; Buccalin-G; Buccalin-H; Buccalin-A; Buccalin-I; Buccalin-J; Buccalin-K; Buccalin-L; Buccalin-B (BUCb); Buccalin-M; Buccalin gene-predicted acidic peptide A (BGPAP A); Buccalin-N; Buccalin-O; Buccalin-P; Buccalin-Q; Buccalin-R; Buccalin-C; Buccalin-S; Buccalin gene-predicted acidic peptide B (BGPAP B)] 0 Aplysia californica (California sea hare) 505 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 0 P25666 CHOYP_NEMVEDRAFT_V1G214498.11.12 m.49080 sp HTRL_ECOLI 26.446 242 158 10 65 291 6 242 1.86E-07 55.1 HTRL_ECOLI reviewed Protein HtrL htrL yibB b3618 JW5644 Escherichia coli (strain K12) 285 lipopolysaccharide biosynthetic process [GO:0009103] GO:0009103 0 0 0 PF09612; P42696 CHOYP_RBM34.1.1 m.14662 sp RBM34_HUMAN 44.776 201 99 3 331 530 170 359 1.86E-49 180 RBM34_HUMAN reviewed RNA-binding protein 34 (RNA-binding motif protein 34) RBM34 KIAA0117 Homo sapiens (Human) 430 0 GO:0000166; GO:0005634; GO:0005730; GO:0044822 0 0 0 PF00076; P49596 CHOYP_NEMVEDRAFT_V1G167304.1.1 m.10864 sp PP2C2_CAEEL 65.781 301 103 0 1 301 1 301 1.86E-149 426 PP2C2_CAEEL reviewed Probable protein phosphatase 2C T23F11.1 (PP2C) (EC 3.1.3.16) ppm-2 T23F11.1 Caenorhabditis elegans 356 negative regulation of axon extension [GO:0030517]; positive regulation of synapse assembly [GO:0051965] GO:0004722; GO:0030517; GO:0031625; GO:0046872; GO:0048786; GO:0051965 0 0 0 PF00481; P49756 CHOYP_RBM25.2.2 m.56526 sp RBM25_HUMAN 88.235 34 4 0 73 106 439 472 1.86E-10 60.5 RBM25_HUMAN reviewed RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7) RBM25 RNPC7 Homo sapiens (Human) 843 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003729; GO:0005654; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0016607; GO:0042981; GO:0044822 0 0 0 PF01480;PF00076; P50882 CHOYP_ACSA.1.1 m.61297 sp RL9_DROME 81.967 61 10 1 1 60 126 186 1.86E-25 97.8 RL9_DROME reviewed 60S ribosomal protein L9 RpL9 M(2)32D CG6141 Drosophila melanogaster (Fruit fly) 190 centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052] GO:0000022; GO:0002181; GO:0003723; GO:0003735; GO:0005840; GO:0007052; GO:0019843; GO:0022625; GO:0051298 0 0 0 PF00347; P90689 CHOYP_ACT.20.27 m.57350 sp ACT_BRUMA 84.466 103 16 0 1 103 1 103 1.86E-55 179 ACT_BRUMA reviewed Actin 0 Brugia malayi (Filarial nematode worm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P97864 CHOYP_CASP7.17.23 m.52767 sp CASP7_MOUSE 30.682 264 137 12 5 245 61 301 1.86E-22 96.7 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q03172 CHOYP_ZEP1.1.1 m.35933 sp ZEP1_MOUSE 52.252 111 42 3 206 306 396 505 1.86E-26 122 ZEP1_MOUSE reviewed Zinc finger protein 40 (Alpha A-crystallin-binding protein 1) (Alpha A-CRYBP1) (Alpha A-crystallin-binding protein I) (Transcription factor alphaA-CRYBP1) Hivep1 Cryabp1 Znf40 Mus musculus (Mouse) 2688 "multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003676; GO:0003677; GO:0005634; GO:0005739; GO:0006351; GO:0007165; GO:0007275; GO:0008270; GO:0045892; GO:0071837 0 0 0 0 Q1HR36 CHOYP_1433G.1.2 m.8906 sp 1433Z_AEDAE 72.18 133 37 0 18 150 116 248 1.86E-67 207 1433Z_AEDAE reviewed 14-3-3 protein zeta 14-3-3zeta AAEL006885 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 248 0 GO:0005737 0 0 0 PF00244; Q23551 CHOYP_LOC100367089.1.4 m.1390 sp UNC22_CAEEL 36.902 523 319 6 183 703 5719 6232 1.86E-105 358 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q2HJ94 CHOYP_DNJA2.2.2 m.51791 sp DNJA2_BOVIN 63.876 418 142 4 26 440 1 412 1.86E-177 504 DNJA2_BOVIN reviewed DnaJ homolog subfamily A member 2 DNAJA2 Bos taurus (Bovine) 412 protein refolding [GO:0042026]; response to heat [GO:0009408] GO:0005524; GO:0005829; GO:0009408; GO:0016020; GO:0042026; GO:0046872; GO:0070062 0 0 cd06257; PF00226;PF01556;PF00684; Q2XWK0 CHOYP_SVOP.2.2 m.8164 sp SVOP_XENLA 44.031 511 272 3 21 517 10 520 1.86E-141 421 SVOP_XENLA reviewed Synaptic vesicle 2-related protein (SV2-related protein) svop Xenopus laevis (African clawed frog) 548 0 GO:0016021; GO:0022857; GO:0030054; GO:0030672 0 0 cd06174; PF07690;PF00083; Q4R684 CHOYP_LOC100372508.1.1 m.30241 sp AMZ2_MACFA 35.326 184 100 2 47 211 140 323 1.86E-29 115 AMZ2_MACFA reviewed Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) AMZ2 QtsA-18820 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 360 0 GO:0008237; GO:0008270 0 0 cd11375; PF07998; Q5BKM3 CHOYP_VPS24.1.1 m.37035 sp CHMP3_XENTR 69.369 111 31 2 1 110 84 192 1.86E-47 155 CHMP3_XENTR reviewed Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Vacuolar protein-sorting-associated protein 24) chmp3 vps24 TEgg091h16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 220 protein transport [GO:0015031]; vacuolar transport [GO:0007034] GO:0005829; GO:0007034; GO:0015031; GO:0031902 0 0 0 PF03357; Q5JUQ0 CHOYP_LOC100668624.1.1 m.49617 sp FA78A_HUMAN 47.126 261 135 2 47 307 23 280 1.86E-78 244 FA78A_HUMAN reviewed Protein FAM78A FAM78A C9orf59 Homo sapiens (Human) 283 0 0 0 0 0 0 Q5TZ18 CHOYP_LOC753295.1.1 m.51466 sp NAV3_DANRE 30.769 104 71 1 125 227 56 159 1.86E-08 62.8 NAV3_DANRE reviewed Neuron navigator 3 nav3 si:dkeyp-60g2.1 Danio rerio (Zebrafish) (Brachydanio rerio) 2269 liver morphogenesis [GO:0072576]; pancreas development [GO:0031016] GO:0003779; GO:0005524; GO:0005640; GO:0005794; GO:0030027; GO:0030175; GO:0031016; GO:0072576 0 0 0 PF00004;PF00307; Q65YR7 CHOYP_CYTA2.2.2 m.31988 sp CYTA2_DICDI 47 100 44 4 27 124 3 95 1.86E-19 79.7 CYTA2_DICDI reviewed Cystatin-A2 cpiB DDB_G0280439 Dictyostelium discoideum (Slime mold) 95 proteolysis [GO:0006508] GO:0004869; GO:0005829; GO:0006508 0 0 0 PF00031; Q66K08 CHOYP_BRAFLDRAFT_88565.1.2 m.15851 sp CILP1_MOUSE 29.301 372 246 10 292 657 152 512 1.86E-37 153 CILP1_MOUSE reviewed Cartilage intermediate layer protein 1 (CILP-1) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] Cilp Mus musculus (Mouse) 1184 negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569] GO:0005578; GO:0005615; GO:0031012; GO:0043569; GO:0070062 0 0 0 PF13330;PF00090; Q6PFY8 CHOYP_BRAFLDRAFT_75787.2.5 m.21483 sp TRI45_MOUSE 28.125 192 115 5 5 184 127 307 1.86E-11 65.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PFY8 CHOYP_RPA1.1.2 m.3320 sp TRI45_MOUSE 22.222 225 151 5 11 222 131 344 1.86E-08 60.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7SIC1 CHOYP_BRAFLDRAFT_89746.2.2 m.47096 sp FUCL_ANGAN 33.871 124 73 4 61 181 35 152 1.86E-10 59.7 FUCL_ANGAN reviewed Fucolectin 0 Anguilla anguilla (European freshwater eel) (Muraena anguilla) 158 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q80TY5 CHOYP_LOC100371084.3.4 m.33416 sp VP13B_MOUSE 32.276 883 535 21 1 835 161 1028 1.86E-128 429 VP13B_MOUSE reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) 4013 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q8AVP1 CHOYP_LOC100374993.1.1 m.30429 sp RPF1_XENLA 62.229 323 117 2 443 760 21 343 1.86E-136 409 RPF1_XENLA reviewed Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1) rpf1 bxdc5 Xenopus laevis (African clawed frog) 343 rRNA processing [GO:0006364] GO:0003723; GO:0005730; GO:0006364; GO:0019843 0 0 0 PF04427; Q8BVQ5 CHOYP_PPME1.1.1 m.56260 sp PPME1_MOUSE 55.448 413 151 5 4 410 1 386 1.86E-152 439 PPME1_MOUSE reviewed Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89) Ppme1 Pme1 Mus musculus (Mouse) 386 protein demethylation [GO:0006482] GO:0006482; GO:0019903; GO:0051721; GO:0051722 0 0 0 PF12697; Q8IVU9 CHOYP_LOC100378886.1.2 m.6971 sp CJ107_HUMAN 36.111 216 127 3 104 319 3 207 1.86E-34 128 CJ107_HUMAN reviewed Uncharacterized protein C10orf107 C10orf107 Homo sapiens (Human) 208 0 0 0 0 0 PF14769; Q8R5F7 CHOYP_IFIH1.10.14 m.60393 sp IFIH1_MOUSE 26.8 847 464 29 841 1588 228 1017 1.86E-54 211 IFIH1_MOUSE reviewed Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Helicase with 2 CARD domains) (Helicard) (Interferon induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (RIG-I-like receptor 2) (RLR-2) Ifih1 Mus musculus (Mouse) 1025 innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; protein sumoylation [GO:0016925]; response to virus [GO:0009615] GO:0003677; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005634; GO:0005737; GO:0008270; GO:0009615; GO:0016925; GO:0032727; GO:0032728; GO:0039530; GO:0043021; GO:0045087 0 0 0 PF16739;PF00271;PF04851;PF11648; Q8STF0 CHOYP_CALM.4.50 m.8049 sp CALM_STRIE 86.957 138 7 1 24 161 9 135 1.86E-80 238 CALM_STRIE reviewed Calmodulin (CaM) 0 Strongylocentrotus intermedius (Sea urchin) 156 0 GO:0005509 0 0 0 PF13499; Q8TDW5 CHOYP_SYTL5.1.1 m.58368 sp SYTL5_HUMAN 45.536 448 202 8 501 912 286 727 1.86E-111 362 SYTL5_HUMAN reviewed Synaptotagmin-like protein 5 SYTL5 SLP5 Homo sapiens (Human) 730 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; intracellular protein transport [GO:0006886]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006886; GO:0006906; GO:0017158; GO:0019905; GO:0030276; GO:0048791; GO:0070382; GO:0098793 0 0 0 PF00168;PF02318; Q91WM2 CHOYP_SMP_149870.1.1 m.15483 sp CECR5_MOUSE 43.478 69 38 1 25 92 45 113 1.86E-11 62 CECR5_MOUSE reviewed Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) 419 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q96S16 CHOYP_JMJD8.1.1 m.64421 sp JMJD8_HUMAN 35.484 248 137 11 154 394 98 329 1.86E-29 119 JMJD8_HUMAN reviewed JmjC domain-containing protein 8 (Jumonji domain-containing protein 8) JMJD8 C16orf20 PP14397 Homo sapiens (Human) 334 0 GO:0070062 0 0 0 0 Q99M80 CHOYP_LOC101160063.4.4 m.45423 sp PTPRT_MOUSE 33.11 299 171 8 386 667 731 1017 1.86E-35 147 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99NA2 CHOYP_ATOH8.1.1 m.11331 sp ATOH8_MOUSE 62.5 96 35 1 237 332 226 320 1.86E-31 123 ATOH8_MOUSE reviewed Protein atonal homolog 8 (Helix-loop-helix protein mATH-6) (mATH6) (Okadin) Atoh8 Ath6 Mus musculus (Mouse) 322 "cell differentiation [GO:0030154]; formation of primary germ layer [GO:0001704]; myoblast proliferation [GO:0051450]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of transcription, DNA-templated [GO:0045893]; SMAD protein signal transduction [GO:0060395]; transcription, DNA-templated [GO:0006351]; tube formation [GO:0035148]" GO:0001704; GO:0001937; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0007399; GO:0008134; GO:0010595; GO:0016607; GO:0030154; GO:0033613; GO:0035148; GO:0045603; GO:0045892; GO:0045893; GO:0051450; GO:0060395; GO:0070888 0 0 0 PF00010; Q9D7V9 CHOYP_DDX10.1.1 m.17783 sp NAAA_MOUSE 44.375 320 174 2 31 350 37 352 1.86E-95 291 NAAA_MOUSE reviewed N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] Naaa Asahl Mus musculus (Mouse) 362 lipid metabolic process [GO:0006629] GO:0005737; GO:0005764; GO:0006629; GO:0008134; GO:0016810; GO:0070062 0 0 0 PF02275;PF15508; Q9HC56 CHOYP_PCDH9.4.5 m.58558 sp PCDH9_HUMAN 34.271 782 487 16 4 769 6 776 1.86E-109 373 PCDH9_HUMAN reviewed Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0030426; GO:0030900; GO:0044291 0 0 0 PF00028;PF08266;PF08374; Q9JJP6 CHOYP_P63.1.1 m.40034 sp P63_RAT 45.025 402 185 13 80 460 50 436 1.86E-95 306 P63_RAT reviewed Tumor protein 63 (p63) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) Tp63 Ket P63 Tp73l Trp63 Rattus norvegicus (Rat) 680 "cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; ectoderm and mesoderm interaction [GO:0007499]; embryonic limb morphogenesis [GO:0030326]; epidermal cell division [GO:0010481]; epithelial cell development [GO:0002064]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mitotic G1 DNA damage checkpoint [GO:0031571]; multicellular organism aging [GO:0010259]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; prostatic bud formation [GO:0060513]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of epidermal cell division [GO:0010482]; regulation of neuron apoptotic process [GO:0043523]; replicative cell aging [GO:0001302]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; sympathetic nervous system development [GO:0048485]; urinary bladder development [GO:0060157]" GO:0000122; GO:0000785; GO:0000790; GO:0000989; GO:0001077; GO:0001302; GO:0001501; GO:0001736; GO:0002039; GO:0002053; GO:0002064; GO:0003682; GO:0003684; GO:0003690; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0005791; GO:0005829; GO:0006338; GO:0006978; GO:0007219; GO:0007283; GO:0007499; GO:0009954; GO:0010165; GO:0010259; GO:0010332; GO:0010481; GO:0010482; GO:0010838; GO:0019904; GO:0030216; GO:0030326; GO:0030425; GO:0030859; GO:0031069; GO:0031571; GO:0034644; GO:0036342; GO:0042475; GO:0042771; GO:0043005; GO:0043066; GO:0043234; GO:0043281; GO:0043523; GO:0043565; GO:0043589; GO:0043616; GO:0044212; GO:0045617; GO:0045669; GO:0045747; GO:0045944; GO:0046872; GO:0048485; GO:0048745; GO:0048807; GO:0051289; GO:0051402; GO:0060157; GO:0060197; GO:0060513; GO:0060529; GO:0061436; GO:1902808; GO:2000271; GO:2000381; GO:2000773; GO:2001235 0 0 cd08367; PF00870;PF07710;PF07647; Q9NQZ5 CHOYP_LOC100374471.1.1 m.55948 sp STAR7_HUMAN 38.333 300 162 7 63 340 23 321 1.86E-66 217 STAR7_HUMAN reviewed "StAR-related lipid transfer protein 7, mitochondrial (Gestational trophoblastic tumor protein 1) (START domain-containing protein 7) (StARD7)" STARD7 GTT1 Homo sapiens (Human) 370 positive regulation of protein targeting to mitochondrion [GO:1903955] GO:0005739; GO:0008289; GO:1903955 0 0 0 PF01852; Q9NYQ7 CHOYP_CELR3.1.1 m.51169 sp CELR3_HUMAN 32.222 180 110 6 6 178 439 613 1.86E-13 71.2 CELR3_HUMAN reviewed Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Homo sapiens (Human) 3312 "axonal fasciculation [GO:0007413]; cilium assembly [GO:0042384]; dopaminergic neuron axon guidance [GO:0036514]; G-protein coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of protein phosphorylation [GO:0001932]; serotonergic neuron axon guidance [GO:0036515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0001764; GO:0001932; GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007186; GO:0007413; GO:0016021; GO:0032880; GO:0036514; GO:0036515; GO:0042384; GO:0060071 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9P0M2 CHOYP_LOC754150.1.1 m.29730 sp AKA7G_HUMAN 30 200 126 4 15 203 85 281 1.86E-19 87.8 AKA7G_HUMAN reviewed A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) 348 0 GO:0000166; GO:0005634; GO:0005829; GO:0051018 0 0 0 PF10469;PF10470; Q9P2E3 CHOYP_LOC663631.2.2 m.49945 sp ZNFX1_HUMAN 38.261 230 122 5 432 654 1347 1563 1.86E-28 125 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9X6U2 CHOYP_BN6_64710.1.1 m.52168 sp BDHA_CUPNH 45.055 91 45 3 12 101 4 90 1.86E-11 62 BDHA_CUPNH reviewed D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) hbdH1 H16_A1334 Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 258 0 GO:0003858 0 0 0 PF00106; A0JMK9 CHOYP_LOC100120677.1.1 m.16799 sp CAF1A_DANRE 39.048 420 225 13 147 547 200 607 1.87E-38 155 CAF1A_DANRE reviewed Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) chaf1a caip150 ch211-129c21.3 zgc:153930 Danio rerio (Zebrafish) (Brachydanio rerio) 863 cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334] GO:0005634; GO:0006260; GO:0006281; GO:0006334; GO:0007049; GO:0031497; GO:0033186 0 0 0 PF15539;PF15557;PF12253; A4IF63 CHOYP_BRAFLDRAFT_87295.4.9 m.33004 sp TRIM2_BOVIN 24.832 149 111 1 117 264 595 743 1.87E-06 52.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A9CPT4 CHOYP_LOC100892150.1.1 m.10319 sp TDRD1_ORYLA 31.628 215 119 6 1413 1627 604 790 1.87E-16 89.4 TDRD1_ORYLA reviewed Tudor domain-containing protein 1 tdrd1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 1133 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0007275; GO:0007281; GO:0007283; GO:0031047; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; B3EWY9 CHOYP_contig_055234 m.65875 sp MLP_ACRMI 27.773 1091 640 40 149 1172 354 1363 1.87E-90 331 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; D2GXS7 CHOYP_METFOR_0399.1.2 m.22779 sp TRIM2_AILME 23.529 153 106 2 222 373 602 744 1.87E-07 56.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E9Q7X6 CHOYP_BRAFLDRAFT_64071.32.35 m.51231 sp HEG1_MOUSE 41.892 74 27 2 3300 3371 949 1008 1.87E-07 61.2 HEG1_MOUSE reviewed Protein HEG homolog 1 Heg1 Mus musculus (Mouse) 1337 cardiac atrium morphogenesis [GO:0003209]; cardiac muscle tissue growth [GO:0055017]; cell-cell junction organization [GO:0045216]; endothelial cell development [GO:0001885]; endothelial cell morphogenesis [GO:0001886]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; lymph circulation [GO:0003017]; lymph vessel development [GO:0001945]; multicellular organism growth [GO:0035264]; pericardium development [GO:0060039]; positive regulation of fibroblast growth factor production [GO:0090271]; post-embryonic development [GO:0009791]; regulation of body fluid levels [GO:0050878]; vasculature development [GO:0001944]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular septum development [GO:0003281]; ventricular trabecula myocardium morphogenesis [GO:0003222] GO:0001570; GO:0001701; GO:0001885; GO:0001886; GO:0001944; GO:0001945; GO:0003017; GO:0003209; GO:0003222; GO:0003281; GO:0005509; GO:0005911; GO:0007507; GO:0009791; GO:0009897; GO:0009986; GO:0016021; GO:0030324; GO:0035264; GO:0045216; GO:0048845; GO:0050878; GO:0055017; GO:0060039; GO:0090271 0 0 0 PF00008;PF07645; O15550 CHOYP_LOC101161131.1.1 m.6045 sp KDM6A_HUMAN 54.918 122 55 0 26 147 149 270 1.87E-37 138 KDM6A_HUMAN reviewed Lysine-specific demethylase 6A (EC 1.14.11.-) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) KDM6A UTX Homo sapiens (Human) 1401 canonical Wnt signaling pathway [GO:0060070]; heart morphogenesis [GO:0003007]; histone H3-K4 methylation [GO:0051568]; in utero embryonic development [GO:0001701]; mesodermal cell differentiation [GO:0048333]; multicellular organism growth [GO:0035264]; neural tube closure [GO:0001843]; notochord morphogenesis [GO:0048570]; positive regulation of gene expression [GO:0010628]; respiratory system process [GO:0003016]; somite rostral/caudal axis specification [GO:0032525] GO:0000978; GO:0001701; GO:0001843; GO:0003007; GO:0003016; GO:0005634; GO:0005654; GO:0010628; GO:0031490; GO:0032452; GO:0032525; GO:0035097; GO:0035264; GO:0044666; GO:0046872; GO:0048333; GO:0048570; GO:0051213; GO:0051568; GO:0060070; GO:0071558 0 0 0 PF02373;PF13181; P10079 CHOYP_TRIADDRAFT_26633.3.6 m.42204 sp FBP1_STRPU 54.717 265 120 0 43 307 214 478 1.87E-82 287 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P16157 CHOYP_AASI_1435.30.35 m.61405 sp ANK1_HUMAN 40.491 163 97 0 5 167 349 511 1.87E-27 110 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P29691 CHOYP_EEF2.2.2 m.54913 sp EF2_CAEEL 84.783 92 14 0 1 92 1 92 1.87E-48 167 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P35408 CHOYP_PE2R4.3.5 m.40418 sp PE2R4_HUMAN 33.846 390 200 12 24 369 19 394 1.87E-50 179 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P35475 CHOYP_IDUA.1.3 m.3781 sp IDUA_HUMAN 52.603 365 162 5 2 363 152 508 1.87E-125 379 IDUA_HUMAN reviewed Alpha-L-iduronidase (EC 3.2.1.76) IDUA Homo sapiens (Human) 653 chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate catabolic process [GO:0030209]; disaccharide metabolic process [GO:0005984]; glycosaminoglycan catabolic process [GO:0006027] GO:0003940; GO:0005984; GO:0006027; GO:0030135; GO:0030207; GO:0030209; GO:0043202; GO:0070062 0 0 0 PF01229; P72745 CHOYP_LOC662357.1.1 m.64856 sp Y1101_SYNY3 49.02 51 26 0 59 109 53 103 1.87E-10 56.6 Y1101_SYNY3 reviewed Universal stress protein Slr1101 (USP Slr1101) slr1101 Synechocystis sp. (strain PCC 6803 / Kazusa) 108 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q02337 CHOYP_BDH1.1.1 m.17777 sp BDH_BOVIN 45.113 266 141 3 29 291 53 316 1.87E-73 233 BDH_BOVIN reviewed "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH)" BDH1 BDH Bos taurus (Bovine) 344 0 GO:0003858; GO:0005654; GO:0005759; GO:0099617 0 0 0 PF00106; Q08420 CHOYP_contig_050645 m.60289 sp SODE_RAT 26.667 150 103 6 31 179 48 191 1.87E-09 58.9 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q12955 CHOYP_TVAG_475680.1.1 m.17223 sp ANK3_HUMAN 22.8 250 167 9 108 352 436 664 1.87E-08 60.8 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q15125 CHOYP_BRAFLDRAFT_262273.1.1 m.11533 sp EBP_HUMAN 46.154 208 109 1 9 213 9 216 1.87E-64 202 EBP_HUMAN reviewed "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EC 5.3.3.5) (Cholestenol Delta-isomerase) (Delta(8)-Delta(7) sterol isomerase) (D8-D7 sterol isomerase) (Emopamil-binding protein)" EBP Homo sapiens (Human) 230 cholesterol biosynthetic process [GO:0006695]; cholesterol biosynthetic process via desmosterol [GO:0033489]; cholesterol biosynthetic process via lathosterol [GO:0033490]; cholesterol metabolic process [GO:0008203]; hemopoiesis [GO:0030097]; skeletal system development [GO:0001501] GO:0000247; GO:0001501; GO:0004769; GO:0004888; GO:0005635; GO:0005783; GO:0005789; GO:0005887; GO:0006695; GO:0008203; GO:0015238; GO:0016023; GO:0030097; GO:0033489; GO:0033490; GO:0047750 "PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000269|PubMed:12760743, ECO:0000269|PubMed:8798407, ECO:0000269|PubMed:9894009}." 0 0 PF05241; Q28113 CHOYP_FUT2.4.5 m.54048 sp FUT2_BOVIN 26.715 277 181 8 111 380 70 331 1.87E-21 97.4 FUT2_BOVIN reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Bos taurus (Bovine) 344 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q2T9I5 CHOYP_BRAFLDRAFT_99641.1.1 m.63666 sp RBM26_XENLA 62.791 86 32 0 2 87 1 86 1.87E-30 120 RBM26_XENLA reviewed RNA-binding protein 26 (RNA-binding motif protein 26) rbm26 Xenopus laevis (African clawed frog) 1059 mRNA processing [GO:0006397]; negative regulation of phosphatase activity [GO:0010923] GO:0000166; GO:0003723; GO:0006397; GO:0010923; GO:0046872 0 0 0 PF01480;PF00076; Q2TJ95 CHOYP_BRAFLDRAFT_219342.2.2 m.57474 sp RSPO3_MOUSE 40.099 202 120 1 1 202 6 206 1.87E-55 181 RSPO3_MOUSE reviewed R-spondin-3 (Cabriolet) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Roof plate-specific spondin-3) Rspo3 Mus musculus (Mouse) 277 angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055] GO:0001525; GO:0001974; GO:0002040; GO:0005102; GO:0005109; GO:0005576; GO:0008201; GO:0016055; GO:0060670; GO:0090263; GO:2000052 0 0 0 PF15913; Q3SXY8 CHOYP_LOC100375027.1.1 m.6547 sp AR13B_HUMAN 45.118 297 154 4 1 292 5 297 1.87E-70 237 AR13B_HUMAN reviewed ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1) ARL13B ARL2L1 Homo sapiens (Human) 428 cilium assembly [GO:0042384]; dorsal/ventral pattern formation [GO:0009953]; formation of radial glial scaffolds [GO:0021943]; heart looping [GO:0001947]; interneuron migration from the subpallium to the cortex [GO:0021830]; left/right axis specification [GO:0070986]; neural tube patterning [GO:0021532]; nonmotile primary cilium assembly [GO:0035058]; small GTPase mediated signal transduction [GO:0007264]; smoothened signaling pathway [GO:0007224] GO:0001947; GO:0005525; GO:0005929; GO:0005930; GO:0007224; GO:0007264; GO:0009953; GO:0021532; GO:0021830; GO:0021943; GO:0031514; GO:0035058; GO:0042384; GO:0060170; GO:0070986; GO:0072372 0 0 0 PF00025; Q460N5 CHOYP_LOC100550444.1.1 m.43358 sp PAR14_HUMAN 25.126 398 256 13 122 510 806 1170 1.87E-22 106 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q571H0 CHOYP_URB1.3.3 m.17984 sp NPA1P_MOUSE 23.741 417 269 14 1 399 451 836 1.87E-22 107 NPA1P_MOUSE reviewed Nucleolar pre-ribosomal-associated protein 1 (URB1 ribosome biogenesis 1 homolog) Urb1 Kiaa0539 Npa1 Mus musculus (Mouse) 2274 0 GO:0005730; GO:0044822 0 0 0 PF16201;PF11707; Q5R7A7 CHOYP_LOC100367974.1.3 m.19352 sp SGK3_PONAB 65.839 322 107 2 26 345 105 425 1.87E-152 459 SGK3_PONAB reviewed Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) SGK3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 496 0 GO:0004674; GO:0005524; GO:0005769; GO:0016023; GO:0035091; GO:0055037 0 0 0 PF00069;PF00433;PF00787; Q5XI32 CHOYP_CAPZB.1.1 m.5762 sp CAPZB_RAT 83.582 268 44 0 93 360 2 269 1.87E-169 476 CAPZB_RAT reviewed F-actin-capping protein subunit beta (CapZ beta) Capzb Rattus norvegicus (Rat) 272 actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591] GO:0000902; GO:0005884; GO:0007010; GO:0008290; GO:0010591; GO:0022604; GO:0030017; GO:0030036; GO:0043025; GO:0043197; GO:0051015; GO:0051016; GO:0051490; GO:0071203 0 0 0 PF01115; Q5ZI87 CHOYP_TBCD.2.2 m.60720 sp TBCD_CHICK 52.304 369 174 1 14 380 24 392 1.87E-125 418 TBCD_CHICK reviewed Tubulin-specific chaperone D (Beta-tubulin cofactor D) (Tubulin-folding cofactor D) TBCD RCJMB04_29e8 Gallus gallus (Chicken) 1019 adherens junction assembly [GO:0034333]; bicellular tight junction assembly [GO:0070830]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of microtubule polymerization [GO:0031115]; positive regulation of GTPase activity [GO:0043547]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] GO:0000226; GO:0005096; GO:0005737; GO:0005874; GO:0005912; GO:0005923; GO:0006457; GO:0007021; GO:0007023; GO:0010812; GO:0016328; GO:0031115; GO:0034333; GO:0043547; GO:0048487; GO:0070830 0 0 0 PF12612; Q6A0A2 CHOYP_LARP4.1.1 m.14987 sp LAR4B_MOUSE 34.658 629 301 25 58 644 52 612 1.87E-75 264 LAR4B_MOUSE reviewed La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5) Larp4b D13Wsu64e Kiaa0217 Larp5 Mus musculus (Mouse) 741 positive regulation of translation [GO:0045727] GO:0000166; GO:0005730; GO:0005737; GO:0005829; GO:0010494; GO:0016020; GO:0042788; GO:0044822; GO:0045727 0 0 0 PF05383; Q6PFY8 CHOYP_LOC100371277.2.2 m.65492 sp TRI45_MOUSE 29.902 204 126 6 8 205 129 321 1.87E-12 73.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PUF3 CHOYP_DHI1L.1.1 m.28132 sp DHI1L_DANRE 47.222 288 137 5 5 292 12 284 1.87E-85 260 DHI1L_DANRE reviewed Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 3) (11-DH3) (11-beta-HSD3) hsd11b1l hsd11b3 hsd3 si:dkey-78l4.15 zgc:56373 Danio rerio (Zebrafish) (Brachydanio rerio) 287 0 GO:0005576; GO:0016229 0 0 0 PF00106; Q6R7G0 CHOYP_LOC100374064.1.4 m.7389 sp Y068_OSHVF 21.694 484 319 12 17 449 26 500 1.87E-27 119 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q76LL6 CHOYP_FHOD3.1.2 m.25522 sp FHOD3_MOUSE 61.111 108 30 3 6 109 1 100 1.87E-36 133 FHOD3_MOUSE reviewed FH1/FH2 domain-containing protein 3 (Formin homolog overexpressed in spleen 2) (mFHOS2) Fhod3 Fhos2 Kiaa1695 Mus musculus (Mouse) 1578 actin filament network formation [GO:0051639]; cardiac myofibril assembly [GO:0055003]; negative regulation of actin filament polymerization [GO:0030837]; sarcomere organization [GO:0045214] GO:0005865; GO:0030017; GO:0030018; GO:0030837; GO:0045214; GO:0051639; GO:0055003 0 0 0 PF02181; Q8AWF2 CHOYP_NACA.9.9 m.65965 sp NACA_ORENI 68.317 101 21 2 13 109 122 215 1.87E-30 110 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q8BFT2 CHOYP_BRAFLDRAFT_275667.1.1 m.17355 sp HAUS4_MOUSE 34.018 341 215 5 20 355 26 361 1.87E-47 167 HAUS4_MOUSE reviewed HAUS augmin-like complex subunit 4 Haus4 D14Ertd500e Mus musculus (Mouse) 363 cell division [GO:0051301]; centrosome organization [GO:0051297]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 PF14735; Q92010 CHOYP_LOC100678227.1.1 m.55796 sp ZBT14_CHICK 35.616 146 86 3 500 642 301 441 1.87E-21 101 ZBT14_CHICK reviewed Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 5) (ZF5) ZBTB14 ZFP161 Gallus gallus (Chicken) 448 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0044212; GO:0045892; GO:0046872 0 0 0 PF00651;PF00096; Q969V5 CHOYP_MUL1.1.1 m.34022 sp MUL1_HUMAN 32.507 363 215 9 12 368 12 350 1.87E-56 191 MUL1_HUMAN reviewed Mitochondrial ubiquitin ligase activator of NFKB 1 (EC 6.3.2.-) (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (MAPL) (Putative NF-kappa-B-activating protein 266) (RING finger protein 218) MUL1 C1orf166 GIDE MAPL MULAN RNF218 Homo sapiens (Human) 352 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; mitochondrial fission [GO:0000266]; mitochondrion localization [GO:0051646]; negative regulation of cell growth [GO:0030308]; negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of innate immune response [GO:0045824]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; positive regulation of dendrite extension [GO:1903861]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein sumoylation [GO:0033235]; protein destabilization [GO:0031648]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of mitochondrion organization [GO:0010821] GO:0000266; GO:0004842; GO:0004871; GO:0005654; GO:0005737; GO:0005739; GO:0005777; GO:0006915; GO:0006919; GO:0007257; GO:0008270; GO:0010637; GO:0010821; GO:0016020; GO:0016567; GO:0016874; GO:0019789; GO:0030308; GO:0030424; GO:0031307; GO:0031625; GO:0031648; GO:0033235; GO:0042802; GO:0043025; GO:0043123; GO:0045824; GO:0050689; GO:0050821; GO:0051646; GO:0051881; GO:0051898; GO:0060339; GO:0071360; GO:0071650; GO:0090141; GO:1901028; GO:1903861 PATHWAY: Protein modification; protein ubiquitination.; PATHWAY: Protein modification; protein sumoylation. 0 0 PF12483; Q96WV6 CHOYP_LELG_02721.1.4 m.19867 sp YHU2_SCHPO 18.593 199 162 0 6 204 1974 2172 1.87E-11 66.2 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q97UU4 CHOYP_LOC100370200.4.5 m.53660 sp Y2899_SULSO 55.056 89 40 0 1200 1288 3 91 1.87E-22 99.4 Y2899_SULSO reviewed Uncharacterized protein SSO2899 SSO2899 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 177 0 0 0 0 0 PF01661; Q9ESN6 CHOYP_TRIM2.24.59 m.33088 sp TRIM2_MOUSE 26.457 223 134 7 169 377 536 742 1.87E-10 66.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9I931 CHOYP_BRAFLDRAFT_189049.2.2 m.59154 sp FUCL1_ANGJA 31.056 161 101 5 72 226 15 171 1.87E-14 72 FUCL1_ANGJA reviewed Fucolectin-1 0 Anguilla japonica (Japanese eel) 178 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9P2K1 CHOYP_CC2D2A.1.2 m.39108 sp C2D2A_HUMAN 37.689 727 394 15 1 707 100 787 1.87E-131 428 C2D2A_HUMAN reviewed Coiled-coil and C2 domain-containing protein 2A CC2D2A KIAA1345 Homo sapiens (Human) 1620 axoneme assembly [GO:0035082]; camera-type eye development [GO:0043010]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; heart development [GO:0007507]; motile cilium assembly [GO:0044458]; motile primary cilium assembly [GO:1903887]; neural tube closure [GO:0001843]; nonmotile primary cilium assembly [GO:0035058]; smoothened signaling pathway [GO:0007224] GO:0001843; GO:0005829; GO:0005856; GO:0007224; GO:0007368; GO:0007507; GO:0035058; GO:0035082; GO:0035869; GO:0036038; GO:0042384; GO:0043010; GO:0044458; GO:0060271; GO:1903887; GO:1990403 0 0 0 PF00168;PF15625; Q9QXW2 CHOYP_LOC100142053.1.2 m.16692 sp FBXW5_MOUSE 25.253 594 359 14 64 631 9 543 1.87E-36 148 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9QYP1 CHOYP_LOC578599.7.8 m.46879 sp LRP4_RAT 28.884 457 296 11 5 445 600 1043 1.87E-53 202 LRP4_RAT reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0034185; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q9V727 CHOYP_LOC584010.1.1 m.11793 sp ASX_DROME 42.053 302 117 6 29 286 51 338 1.87E-57 220 ASX_DROME reviewed Polycomb protein Asx (Additional sex combs) Asx CG8787 Drosophila melanogaster (Fruit fly) 1669 "antennal development [GO:0007469]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; cell fate determination [GO:0001709]; monoubiquitinated histone H2A deubiquitination [GO:0035522]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of gene expression [GO:0010468]; regulation of ubiquitin-specific protease activity [GO:2000152]; sex comb development [GO:0045498]; syncytial blastoderm mitotic cell cycle [GO:0035186]; transcription, DNA-templated [GO:0006351]" GO:0000785; GO:0001709; GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0007469; GO:0007475; GO:0010468; GO:0035186; GO:0035517; GO:0035522; GO:0035800; GO:0045498; GO:0045892; GO:0045893; GO:0046872; GO:2000152 0 0 0 PF13919;PF13922; Q9V8M2 CHOYP_BRAFLDRAFT_91871.2.3 m.44434 sp C12B2_DROME 28.922 529 342 12 16 524 15 529 1.87E-73 245 C12B2_DROME reviewed "Probable cytochrome P450 12b2, mitochondrial (EC 1.14.-.-) (CYPXIIB2)" Cyp12b2 CG15077 Drosophila melanogaster (Fruit fly) 535 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037; GO:0031966 0 0 0 PF00067; Q9WU63 CHOYP_HEBP2.2.2 m.50861 sp HEBP2_MOUSE 31.783 129 80 4 4 130 35 157 1.87E-10 60.5 HEBP2_MOUSE reviewed Heme-binding protein 2 (Protein SOUL) Hebp2 Soul Mus musculus (Mouse) 205 negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of necrotic cell death [GO:0010940] GO:0005737; GO:0005739; GO:0010917; GO:0010940; GO:0035794; GO:0070062 0 0 0 PF04832; A2ASS6 CHOYP_LOC100367089.3.4 m.39677 sp TITIN_MOUSE 29.743 1439 967 19 6647 8064 14048 15463 1.88E-179 633 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A8DYE2 CHOYP_contig_026201 m.29841 sp TRPCG_DROME 30.986 142 89 4 3 141 1115 1250 1.88E-15 77 TRPCG_DROME reviewed "Transient receptor potential cation channel trpm (Transient receptor potential cation channel, subfamily M ortholog)" Trpm CG44240 Drosophila melanogaster (Fruit fly) 2023 cell growth [GO:0016049]; divalent metal ion transport [GO:0070838]; magnesium ion homeostasis [GO:0010960]; mitochondrion organization [GO:0007005]; protein tetramerization [GO:0051262]; zinc ion homeostasis [GO:0055069] GO:0005261; GO:0007005; GO:0010960; GO:0016049; GO:0034703; GO:0046873; GO:0051262; GO:0055069; GO:0070838; GO:0097682 0 0 0 PF00520;PF16519; A8MXQ7 CHOYP_LOC100183353.1.1 m.54920 sp YH010_HUMAN 27.206 136 81 4 67 201 462 580 1.88E-07 54.3 YH010_HUMAN reviewed Putative IQ motif and ankyrin repeat domain-containing protein LOC642574 0 Homo sapiens (Human) 604 0 0 0 0 0 0 B0JZV4 CHOYP_LOC100893981.1.1 m.56774 sp CBPC5_XENTR 65.294 340 113 2 3 338 2 340 1.88E-153 487 CBPC5_XENTR reviewed Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (ATP/GTP-binding protein-like 5) agbl5 ccp5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 944 defense response to virus [GO:0051607]; protein branching point deglutamylation [GO:0035611]; protein deglutamylation [GO:0035608] GO:0004181; GO:0005634; GO:0005829; GO:0008270; GO:0015631; GO:0030496; GO:0035608; GO:0035611; GO:0051607; GO:0072686 0 0 0 PF00246; D2GXS7 CHOYP_BRAFLDRAFT_205965.32.43 m.52745 sp TRIM2_AILME 24.476 143 107 1 149 291 602 743 1.88E-07 56.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZAT9 CHOYP_LOC100377010.3.16 m.9145 sp FAXC_RAT 34.601 263 156 3 30 285 90 343 1.88E-58 195 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; O00370 CHOYP_NEMVEDRAFT_V1G154278.1.1 m.40044 sp LORF2_HUMAN 26.429 140 100 1 3 139 8 147 1.88E-12 68.2 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O16025 CHOYP_LOC584481.10.10 m.66365 sp AOSL_PLEHO 32.81 701 418 17 4 662 376 1065 1.88E-108 355 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O16277 CHOYP_LOC100373506.4.8 m.35531 sp H16_CAEEL 42.975 121 55 4 14 131 1 110 1.88E-20 87 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O46385 CHOYP_SVIL.1.1 m.1141 sp SVIL_BOVIN 40.625 128 74 1 12 139 1863 1988 1.88E-26 106 SVIL_BOVIN reviewed Supervillin (Archvillin) (p205/p250) SVIL Bos taurus (Bovine) 2194 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467] GO:0002102; GO:0005737; GO:0005886; GO:0007010; GO:0030054; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0071437 0 0 0 PF00626;PF02209; O49636 CHOYP_PHUM_PHUM335300.1.1 m.43345 sp MPC4_ARATH 47.573 103 53 1 30 132 1 102 1.88E-28 103 MPC4_ARATH reviewed Mitochondrial pyruvate carrier 4 MPC4 At4g22310 T10I14_140 Arabidopsis thaliana (Mouse-ear cress) 108 mitochondrial pyruvate transport [GO:0006850] GO:0005739; GO:0005743; GO:0006850; GO:0016021 0 0 0 PF03650; O60290 CHOYP_NEMVEDRAFT_V1G241686.1.1 m.31652 sp ZN862_HUMAN 23.471 507 350 17 140 636 595 1073 1.88E-22 106 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; O75095 CHOYP_LOC753176.1.3 m.24292 sp MEGF6_HUMAN 35.98 806 463 32 5 799 628 1391 1.88E-97 335 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75179 CHOYP_LOC753709.7.44 m.20051 sp ANR17_HUMAN 35.02 494 298 15 2 476 229 718 1.88E-62 226 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P04792 CHOYP_LOC100211409.1.1 m.4743 sp HSPB1_HUMAN 32.099 81 54 1 46 125 89 169 1.88E-06 50.1 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P06132 CHOYP_DCUP.1.1 m.7527 sp DCUP_HUMAN 57.895 361 150 1 8 368 9 367 1.88E-151 434 DCUP_HUMAN reviewed Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) UROD Homo sapiens (Human) 367 cellular response to arsenic-containing substance [GO:0071243]; heme biosynthetic process [GO:0006783]; liver development [GO:0001889]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to amine [GO:0014075]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; response to iron ion [GO:0010039]; response to mercury ion [GO:0046689]; response to methylmercury [GO:0051597]; uroporphyrinogen III metabolic process [GO:0046502] GO:0001889; GO:0004853; GO:0005654; GO:0005737; GO:0005829; GO:0006782; GO:0006783; GO:0008198; GO:0010039; GO:0014075; GO:0032355; GO:0045471; GO:0046502; GO:0046689; GO:0051597; GO:0060992; GO:0071243 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. 0 cd00717; PF01208; P24862 CHOYP_CCNB.2.2 m.16937 sp CCNB_PATVU 61.611 422 141 7 10 426 1 406 1.88E-177 504 CCNB_PATVU reviewed G2/mitotic-specific cyclin-B 0 Patella vulgata (Common limpet) 408 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134; P32429 CHOYP_RL7A.6.6 m.40438 sp RL7A_CHICK 78.195 133 29 0 3 135 101 233 1.88E-72 222 RL7A_CHICK reviewed 60S ribosomal protein L7a RPL7A SURF-3 Gallus gallus (Chicken) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0022625; GO:0042788; GO:0044822; GO:0070062 0 0 0 PF01248; P62909 CHOYP_RS3.7.7 m.57678 sp RS3_RAT 90 110 10 1 1 110 127 235 1.88E-66 203 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; P62909 CHOYP_RS32.1.1 m.57159 sp RS3_RAT 90 110 10 1 1 110 127 235 1.88E-66 203 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; P86854 CHOYP_CD209A.2.2 m.62956 sp PLCL_MYTGA 33.333 156 99 4 10 162 3 156 1.88E-21 87.8 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P91573 CHOYP_contig_045884 m.53550 sp WRT6_CAEEL 51.111 45 22 0 115 159 341 385 1.88E-06 50.1 WRT6_CAEEL reviewed Warthog protein 6 [Cleaved into: Warthog protein 6 N-product; Warthog protein 6 C-product] wrt-6 ZK377.1 Caenorhabditis elegans 593 cell-cell signaling [GO:0007267]; intein-mediated protein splicing [GO:0016539]; multicellular organism development [GO:0007275] GO:0005615; GO:0005886; GO:0007267; GO:0007275; GO:0008233; GO:0009986; GO:0016539 0 0 0 PF01079; P91943 CHOYP_PANG1.1.2 m.10756 sp PANG1_DROME 43.315 531 211 26 3 474 1 500 1.88E-91 298 PANG1_DROME reviewed "Protein pangolin, isoforms A/H/I/S (dTCF)" pan TCF CG34403 Drosophila melanogaster (Fruit fly) 751 "embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; imaginal disc-derived wing morphogenesis [GO:0007476]; mesodermal cell fate determination [GO:0007500]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of hemocyte differentiation [GO:0045610]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription, DNA-templated [GO:0006355]; regulation of Wnt signaling pathway [GO:0030111]; salivary gland morphogenesis [GO:0007435]; segment polarity determination [GO:0007367]; spiracle morphogenesis, open tracheal system [GO:0035277]; transcription from RNA polymerase II promoter [GO:0006366]; Wnt signaling pathway [GO:0016055]" GO:0003705; GO:0005634; GO:0005667; GO:0005875; GO:0006355; GO:0006366; GO:0007367; GO:0007435; GO:0007476; GO:0007500; GO:0007507; GO:0009880; GO:0010628; GO:0016055; GO:0019900; GO:0030111; GO:0030178; GO:0035277; GO:0043565; GO:0045610; GO:0045892; GO:0045893; GO:0045944; GO:0070491; GO:0072091 0 0 0 PF08347;PF00505; P98133 CHOYP_LOC100638363.2.2 m.15064 sp FBN1_BOVIN 29.077 791 391 37 58 710 1135 1893 1.88E-51 203 FBN1_BOVIN reviewed Fibrillin-1 (MP340) [Cleaved into: Asprosin] FBN1 Bos taurus (Bovine) 2871 activation of protein kinase A activity [GO:0034199]; anatomical structure morphogenesis [GO:0009653]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein kinase A signaling [GO:0010737]; regulation of cellular response to growth factor stimulus [GO:0090287] GO:0001527; GO:0005179; GO:0005201; GO:0005509; GO:0005576; GO:0005615; GO:0005622; GO:0006006; GO:0008201; GO:0009653; GO:0010737; GO:0034199; GO:0042593; GO:0090287 0 0 0 PF12662;PF07645;PF00683; Q00438 CHOYP_PTBP1.2.2 m.8212 sp PTBP1_RAT 35.025 197 117 3 157 345 358 551 1.88E-27 116 PTBP1_RAT reviewed Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) (Pyrimidine-binding protein) (PYBP) Ptbp1 Ptb Pybp Tbfii Rattus norvegicus (Rat) 555 "3'-UTR-mediated mRNA stabilization [GO:0070935]; cardiac ventricle development [GO:0003231]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of insulin secretion [GO:0032024]; positive regulation of neuron projection development [GO:0010976]; positive regulation of secretory granule organization [GO:1904411]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" GO:0000014; GO:0000166; GO:0000381; GO:0000956; GO:0001069; GO:0003231; GO:0003697; GO:0003729; GO:0005634; GO:0005737; GO:0006397; GO:0008380; GO:0010976; GO:0032024; GO:0043565; GO:0044306; GO:0045727; GO:0048025; GO:0051148; GO:0070935; GO:1904411 0 0 0 PF00076; Q08420 CHOYP_UBP37.1.1 m.15559 sp SODE_RAT 27.333 150 102 6 21 169 48 191 1.88E-10 61.6 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q0P457 CHOYP_KTI12.1.1 m.10943 sp KTI12_DANRE 56.727 275 118 1 1 275 1 274 1.88E-121 350 KTI12_DANRE reviewed Protein KTI12 homolog kti12 si:dkey-77f17.5 zgc:153393 Danio rerio (Zebrafish) (Brachydanio rerio) 275 0 GO:0005524 0 0 0 PF08433; Q1RK13 CHOYP_LOC100641396.27.27 m.66437 sp Y220_RICBR 31.579 266 159 3 251 494 327 591 1.88E-26 117 Y220_RICBR reviewed Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) 826 0 0 0 0 0 PF00023;PF12796; Q1RLY6 CHOYP_KMO.2.2 m.23794 sp KMO_DANRE 44.037 436 236 4 4 433 17 450 1.88E-132 393 KMO_DANRE reviewed Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase) kmo zgc:136684 Danio rerio (Zebrafish) (Brachydanio rerio) 474 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; kynurenine metabolic process [GO:0070189]; NAD metabolic process [GO:0019674]; quinolinate biosynthetic process [GO:0019805]; response to yeast [GO:0001878]; secondary metabolite biosynthetic process [GO:0044550]; tryptophan catabolic process [GO:0006569] GO:0001878; GO:0004502; GO:0005741; GO:0006569; GO:0016021; GO:0016174; GO:0019674; GO:0019805; GO:0034354; GO:0043420; GO:0044550; GO:0050660; GO:0070189; GO:0071949 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. {ECO:0000255|HAMAP-Rule:MF_03018}. 0 0 PF01494; Q1RM03 CHOYP_LOC100377118.1.1 m.40705 sp TCHP_DANRE 47.343 414 218 0 1 414 1 414 1.88E-108 334 TCHP_DANRE reviewed Trichoplein keratin filament-binding protein (Protein TCHP) tchp zgc:136634 Danio rerio (Zebrafish) (Brachydanio rerio) 499 0 GO:0005737; GO:0005856 0 0 0 0 Q26636 CHOYP_CTSL2.2.2 m.33742 sp CATL_SARPE 52 300 137 3 53 345 25 324 1.88E-109 326 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q27218 CHOYP_ACH7.2.2 m.66217 sp ACH7_CAEEL 25.658 456 275 14 119 529 39 475 1.88E-39 153 ACH7_CAEEL reviewed Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1) lev-1 F09E8.7 Caenorhabditis elegans 507 "inorganic cation transmembrane transport [GO:0098662]; neuromuscular synaptic transmission [GO:0007274]; regulation of locomotion [GO:0040012]; regulation of oviposition [GO:0046662]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0040012; GO:0043005; GO:0043025; GO:0045211; GO:0046662; GO:0098662 0 0 0 PF02931;PF02932; Q2EMV9 CHOYP_LOC100704951.1.1 m.9055 sp PAR14_MOUSE 24.627 268 165 7 14 278 1447 1680 1.88E-14 77 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q32KR8 CHOYP_BRAFLDRAFT_212086.5.11 m.47778 sp ADPRH_BOVIN 55.714 350 148 4 8 356 9 352 1.88E-126 374 ADPRH_BOVIN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Bos taurus (Bovine) 353 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q32NR4 CHOYP_BRAFLDRAFT_121105.1.1 m.41883 sp TTC29_XENLA 40.561 392 231 2 57 447 58 448 1.88E-95 300 TTC29_XENLA reviewed Tetratricopeptide repeat protein 29 (TPR repeat protein 29) ttc29 Xenopus laevis (African clawed frog) 487 0 0 0 0 0 0 Q3SZE9 CHOYP_BRAFLDRAFT_84941.1.1 m.53224 sp TBCC_BOVIN 41.379 348 174 6 131 464 9 340 1.88E-85 269 TBCC_BOVIN reviewed Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC) TBCC Bos taurus (Bovine) 345 cell morphogenesis [GO:0000902]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] GO:0000902; GO:0003924; GO:0005737; GO:0005829; GO:0006457; GO:0007021; GO:0007023; GO:0032391 0 0 0 PF07986;PF16752; Q40588 CHOYP_LOC100206475.14.16 m.57853 sp ASO_TOBAC 26.325 604 328 20 143 716 50 566 1.88E-46 177 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q4ZHG4 CHOYP_contig_032715 m.37379 sp FNDC1_HUMAN 41.406 128 71 3 195 321 1767 1891 1.88E-20 100 FNDC1_HUMAN reviewed Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) FNDC1 FNDC2 KIAA1866 MEL4B3 Homo sapiens (Human) 1894 0 GO:0005576; GO:0005654 0 0 0 PF00041; Q502M6 CHOYP_LOC100634041.1.3 m.32916 sp ANR29_DANRE 40.113 177 106 0 1 177 53 229 1.88E-37 133 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q58CS8 CHOYP_GNPTG.1.2 m.22536 sp GNPTG_BOVIN 47.39 249 119 3 46 294 27 263 1.88E-76 240 GNPTG_BOVIN reviewed N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma) GNPTG Bos taurus (Bovine) 306 carbohydrate phosphorylation [GO:0046835] GO:0005794; GO:0042803; GO:0046835; GO:0070062 0 0 0 PF13015; Q5RJ80 CHOYP_ACTNB.1.1 m.22935 sp CAPR2_DANRE 31.818 132 81 4 316 442 784 911 1.88E-10 66.6 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5U5Q3 CHOYP_MEX3B.1.1 m.10543 sp MEX3C_HUMAN 46.311 488 191 15 63 535 226 657 1.88E-111 348 MEX3C_HUMAN reviewed RNA-binding E3 ubiquitin-protein ligase MEX3C (EC 6.3.2.-) (RING finger and KH domain-containing protein 2) (RING finger protein 194) MEX3C RKHD2 RNF194 BM-013 Homo sapiens (Human) 659 chondrocyte hypertrophy [GO:0003415]; energy homeostasis [GO:0097009]; mitophagy in response to mitochondrial depolarization [GO:0098779]; regulation of fat cell differentiation [GO:0045598] GO:0003415; GO:0005634; GO:0005737; GO:0008270; GO:0016874; GO:0044822; GO:0045598; GO:0097009; GO:0098779 0 0 0 PF00013; Q5ZLG9 CHOYP_WDR59.3.5 m.39120 sp WDR59_CHICK 39.669 484 254 11 1 468 291 752 1.88E-92 307 WDR59_CHICK reviewed WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) 973 cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034198; GO:0061700 0 0 0 PF00400; Q6NWD4 CHOYP_BRAFLDRAFT_265448.1.1 m.27000 sp TIM50_DANRE 47.458 295 147 4 81 369 78 370 1.88E-84 265 TIM50_DANRE reviewed Mitochondrial import inner membrane translocase subunit TIM50 timm50 tim50 zgc:66357 Danio rerio (Zebrafish) (Brachydanio rerio) 387 apoptotic process [GO:0006915]; mitochondrial membrane organization [GO:0007006]; protein dephosphorylation [GO:0006470]; protein import into mitochondrial matrix [GO:0030150] GO:0004721; GO:0004722; GO:0004725; GO:0005743; GO:0005744; GO:0006470; GO:0006915; GO:0007006; GO:0016021; GO:0030150 0 0 0 PF03031; Q6Q899 CHOYP_IFIH1.11.14 m.61919 sp DDX58_MOUSE 28.169 923 570 27 135 1003 14 897 1.88E-92 318 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q7TM99 CHOYP_CPIPJ_CPIJ012631.1.1 m.22929 sp MOT9_MOUSE 27.957 558 312 10 28 576 7 483 1.88E-53 194 MOT9_MOUSE reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) Slc16a9 Mct9 Mus musculus (Mouse) 508 urate metabolic process [GO:0046415] GO:0005886; GO:0008028; GO:0015293; GO:0016021; GO:0046415 0 0 cd06174; PF07690; Q7ZVK3 CHOYP_LOC100744089.1.1 m.58530 sp SIR2_DANRE 53.134 367 145 8 10 368 20 367 1.88E-124 366 SIR2_DANRE reviewed NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) sirt2 zgc:77003 Danio rerio (Zebrafish) (Brachydanio rerio) 379 cellular response to caloric restriction [GO:0061433]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cilium morphogenesis [GO:0060271]; histone H4 deacetylation [GO:0070933]; negative regulation of autophagy [GO:0010507]; negative regulation of cell proliferation [GO:0008285]; negative regulation of oligodendrocyte progenitor proliferation [GO:0070446]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; positive regulation of DNA binding [GO:0043388]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [GO:2000777]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein deacetylation [GO:0006476]; regulation of cell cycle [GO:0051726]; tubulin deacetylation [GO:0090042] GO:0000122; GO:0004407; GO:0005634; GO:0005694; GO:0005720; GO:0005737; GO:0005813; GO:0005814; GO:0005819; GO:0005829; GO:0006476; GO:0008270; GO:0008285; GO:0010507; GO:0030496; GO:0032436; GO:0033010; GO:0033270; GO:0034599; GO:0034979; GO:0042177; GO:0042903; GO:0043204; GO:0043209; GO:0043220; GO:0043388; GO:0044224; GO:0045944; GO:0046970; GO:0048471; GO:0051726; GO:0060271; GO:0061428; GO:0061433; GO:0070403; GO:0070446; GO:0070933; GO:0071456; GO:0072686; GO:0072687; GO:0090042; GO:0097386; GO:1900119; GO:2000378; GO:2000777 0 0 0 PF02146; Q7ZVK3 CHOYP_LOC585308.1.1 m.59828 sp SIR2_DANRE 50.456 329 157 4 51 377 39 363 1.88E-114 344 SIR2_DANRE reviewed NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) sirt2 zgc:77003 Danio rerio (Zebrafish) (Brachydanio rerio) 379 cellular response to caloric restriction [GO:0061433]; cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cilium morphogenesis [GO:0060271]; histone H4 deacetylation [GO:0070933]; negative regulation of autophagy [GO:0010507]; negative regulation of cell proliferation [GO:0008285]; negative regulation of oligodendrocyte progenitor proliferation [GO:0070446]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; positive regulation of DNA binding [GO:0043388]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [GO:2000777]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein deacetylation [GO:0006476]; regulation of cell cycle [GO:0051726]; tubulin deacetylation [GO:0090042] GO:0000122; GO:0004407; GO:0005634; GO:0005694; GO:0005720; GO:0005737; GO:0005813; GO:0005814; GO:0005819; GO:0005829; GO:0006476; GO:0008270; GO:0008285; GO:0010507; GO:0030496; GO:0032436; GO:0033010; GO:0033270; GO:0034599; GO:0034979; GO:0042177; GO:0042903; GO:0043204; GO:0043209; GO:0043220; GO:0043388; GO:0044224; GO:0045944; GO:0046970; GO:0048471; GO:0051726; GO:0060271; GO:0061428; GO:0061433; GO:0070403; GO:0070446; GO:0070933; GO:0071456; GO:0072686; GO:0072687; GO:0090042; GO:0097386; GO:1900119; GO:2000378; GO:2000777 0 0 0 PF02146; Q7ZWG6 CHOYP_LOC101171601.1.1 m.60269 sp PCFT_DANRE 28.814 413 267 9 70 467 77 477 1.88E-38 150 PCFT_DANRE reviewed Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) 481 transmembrane transport [GO:0055085] GO:0005542; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q8IRR5 CHOYP_LOC589067.1.1 m.19628 sp SIR4_DROME 56.989 93 40 0 18 110 15 107 1.88E-31 116 SIR4_DROME reviewed NAD-dependent protein deacylase Sirt4 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 4) Sirt4 CG3187 Drosophila melanogaster (Fruit fly) 312 histone deacetylation [GO:0016575]; protein ADP-ribosylation [GO:0006471] GO:0004407; GO:0005739; GO:0005759; GO:0006471; GO:0008270; GO:0016575; GO:0034979; GO:0070403 0 0 0 PF02146; Q8IWZ3 CHOYP_LOC581927.23.27 m.59557 sp ANKH1_HUMAN 35.526 456 276 13 822 1261 207 660 1.88E-56 219 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8K0U4 CHOYP_BRAFLDRAFT_208197.5.21 m.21756 sp HS12A_MOUSE 35.908 479 250 11 15 439 56 531 1.88E-81 267 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8NFD2 CHOYP_TVAG_123950.10.31 m.32936 sp ANKK1_HUMAN 36.937 222 138 1 4 223 373 594 1.88E-35 136 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8QGW7 CHOYP_NEMVEDRAFT_V1G129909.5.9 m.23618 sp LITAF_CHICK 41.026 156 74 4 3 158 11 148 1.88E-24 95.1 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8R040 CHOYP_BRAFLDRAFT_275493.1.1 m.24982 sp RPP21_MOUSE 31.068 103 69 2 10 111 12 113 1.88E-12 63.2 RPP21_MOUSE reviewed Ribonuclease P protein subunit p21 (RNaseP protein p21) (EC 3.1.26.5) (Ribonucleoprotein V) Rpp21 Cat60 Mus musculus (Mouse) 150 response to drug [GO:0042493]; tRNA processing [GO:0008033] GO:0004526; GO:0005655; GO:0008033; GO:0042493; GO:0046872 0 0 0 PF04032; Q96M69 CHOYP_LOC100375230.1.1 m.52612 sp LRGUK_HUMAN 39.891 732 405 9 76 785 104 822 1.88E-170 515 LRGUK_HUMAN reviewed Leucine-rich repeat and guanylate kinase domain-containing protein LRGUK Homo sapiens (Human) 825 axoneme assembly [GO:0035082]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0001669; GO:0002177; GO:0005524; GO:0005654; GO:0005737; GO:0007283; GO:0016301; GO:0030154; GO:0035082 0 0 0 PF00625; Q9BDB7 CHOYP_LOC101165968.1.7 m.318 sp IF44L_MOUSE 30.088 452 278 8 14 450 7 435 1.88E-50 181 IF44L_MOUSE reviewed Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) 447 immune response [GO:0006955] GO:0005654; GO:0005737; GO:0006955 0 0 0 0 Q9CXG3 CHOYP_PPIL4.1.1 m.2390 sp PPIL4_MOUSE 55.491 173 65 3 1 161 236 408 1.88E-47 169 PPIL4_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) Ppil4 Mus musculus (Mouse) 492 protein folding [GO:0006457] GO:0000166; GO:0003755; GO:0005654; GO:0005737; GO:0006457; GO:0044822 0 0 0 PF00160;PF00076; Q9GNN8 CHOYP_CTXA.2.2 m.36814 sp CTXA_CARAL 21.447 387 222 15 42 365 96 463 1.88E-10 66.2 CTXA_CARAL reviewed Toxin CaTX-A (Toxin A) (CAT-1) 0 Carybdea alata (Hawaiian box jellyfish) 463 hemolysis in other organism [GO:0044179]; ion transport [GO:0006811] GO:0005576; GO:0006811; GO:0016021; GO:0042151; GO:0044179; GO:0044218 0 0 0 0 Q9JJH7 CHOYP_TRPM8.4.5 m.63520 sp TRPM5_MOUSE 29.851 335 207 10 60 390 709 1019 1.88E-34 140 TRPM5_MOUSE reviewed Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein) Trpm5 Ltrpc5 Mtr1 Mus musculus (Mouse) 1158 ion transmembrane transport [GO:0034220]; sensory perception of taste [GO:0050909] GO:0005227; GO:0005244; GO:0005267; GO:0005272; GO:0005886; GO:0016021; GO:0030425; GO:0034220; GO:0043025; GO:0050909 0 0 0 PF00520; Q9NGC3 CHOYP_CEG1A.2.6 m.3125 sp CEG1A_DROME 83.594 128 19 1 16 141 75 202 1.88E-67 223 CEG1A_DROME reviewed Centaurin-gamma-1A CenG1A CG31811 Drosophila melanogaster (Fruit fly) 995 medium-term memory [GO:0072375]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005096; GO:0005525; GO:0005622; GO:0007264; GO:0016020; GO:0043087; GO:0043547; GO:0046872; GO:0072375 0 0 0 PF01412;PF00071; Q9PTG8 CHOYP_BRAFLDRAFT_126155.1.1 m.45875 sp TACC3_XENLA 31.325 415 218 11 730 1139 577 929 1.88E-36 153 TACC3_XENLA reviewed Transforming acidic coiled-coil-containing protein 3 (Cytoplasmic polyadenylation element-binding protein-associated factor Maskin) (CPEB-associated factor Maskin) tacc3 maskin Xenopus laevis (African clawed frog) 931 negative regulation of translation [GO:0017148] GO:0005737; GO:0017148; GO:0031369; GO:0043234 0 0 0 PF05010; Q9R0Z7 CHOYP_LOC100653683.1.1 m.7478 sp AAGAB_RAT 35.608 337 183 6 10 346 8 310 1.88E-54 184 AAGAB_RAT reviewed Alpha- and gamma-adaptin-binding protein p34 Aagab P34 Rattus norvegicus (Rat) 315 protein transport [GO:0015031] GO:0005654; GO:0005829; GO:0015031 0 0 0 PF10199; Q9R1R2 CHOYP_BRAFLDRAFT_206799.13.23 m.42056 sp TRIM3_MOUSE 25.926 135 81 4 189 308 614 744 1.88E-07 56.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9SE95 CHOYP_LOC100377510.1.4 m.1902 sp FIP2_ARATH 54.839 93 37 2 425 516 11 99 1.88E-22 101 FIP2_ARATH reviewed FH protein interacting protein FIP2 (BTB/POZ domain-containing protein At5g55000) FIP2 At5g55000 MBG8.27 Arabidopsis thaliana (Mouse-ear cress) 298 protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] GO:0016567; GO:0051260 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02214;PF00805; Q9UGM3 CHOYP_LOC100636158.1.1 m.44452 sp DMBT1_HUMAN 27.02 1943 1056 63 1458 3094 99 1985 1.88E-151 532 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9V895 CHOYP_BRAFLDRAFT_239771.1.1 m.4551 sp AN32A_DROME 60 170 65 1 5 174 1 167 1.88E-62 202 AN32A_DROME reviewed Acidic leucine-rich nuclear phosphoprotein 32 family member A Anp32a Mapmodulin CG5784 Drosophila melanogaster (Fruit fly) 261 microtubule-based process [GO:0007017]; nucleocytoplasmic transport [GO:0006913] GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005875; GO:0006913; GO:0007017; GO:0008017; GO:0048471 0 0 0 0 Q9Z2W1 CHOYP_STK24.1.1 m.13301 sp STK25_MOUSE 65.625 416 122 9 9 419 13 412 1.88E-177 505 STK25_MOUSE reviewed Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) Stk25 Sok1 Mus musculus (Mouse) 426 establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542] GO:0000139; GO:0004702; GO:0005524; GO:0005737; GO:0006468; GO:0007163; GO:0032874; GO:0036481; GO:0042542; GO:0042803; GO:0046777; GO:0046872; GO:0050772; GO:0051645; GO:0051683; GO:0070062; GO:0090168 0 0 0 PF00069; A3KP77 CHOYP_OXND1.1.2 m.15021 sp OXND1_DANRE 44.03 268 141 3 4 265 6 270 1.89E-78 241 OXND1_DANRE reviewed Oxidoreductase NAD-binding domain-containing protein 1 (EC 1.-.-.-) oxnad1 Danio rerio (Zebrafish) (Brachydanio rerio) 270 0 GO:0005739; GO:0016491; GO:0071949 0 0 0 PF00175; A5PKG7 CHOYP_LOC100068494.1.1 m.8733 sp KCTD5_BOVIN 81.25 192 36 0 23 214 43 234 1.89E-114 328 KCTD5_BOVIN reviewed BTB/POZ domain-containing protein KCTD5 KCTD5 Bos taurus (Bovine) 234 protein homooligomerization [GO:0051260] GO:0005829; GO:0051260 0 0 0 PF02214; A7YY35 CHOYP_IFRX2.5.10 m.28639 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 1.89E-19 98.6 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; F7E235 CHOYP_LOC100377010.2.16 m.8604 sp FAXC_XENTR 35.616 146 81 3 1 137 192 333 1.89E-25 102 FAXC_XENTR reviewed Failed axon connections homolog faxc Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 406 0 GO:0016021 0 0 0 PF17171;PF17172; G3V9H8 CHOYP_RET.1.1 m.31383 sp RET_RAT 42.52 635 288 12 418 1040 462 1031 1.89E-143 464 RET_RAT reviewed Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] Ret Rattus norvegicus (Rat) 1115 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to retinoic acid [GO:0071300]; embryonic epithelial tube formation [GO:0001838]; enteric nervous system development [GO:0048484]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; innervation [GO:0060384]; MAPK cascade [GO:0000165]; membrane protein proteolysis [GO:0033619]; neural crest cell migration [GO:0001755]; neuron cell-cell adhesion [GO:0007158]; neuron maturation [GO:0042551]; Peyer's patch morphogenesis [GO:0061146]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell migration [GO:0030335]; positive regulation of cell size [GO:0045793]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of serine phosphorylation of STAT3 protein [GO:1903263]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of axonogenesis [GO:0050770]; response to drug [GO:0042493]; response to pain [GO:0048265]; retina development in camera-type eye [GO:0060041]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ureteric bud development [GO:0001657]; ureter maturation [GO:0035799]" GO:0000165; GO:0001657; GO:0001755; GO:0001838; GO:0004714; GO:0005509; GO:0005524; GO:0005769; GO:0005887; GO:0006919; GO:0007156; GO:0007158; GO:0007169; GO:0010008; GO:0010976; GO:0014042; GO:0030335; GO:0030424; GO:0030425; GO:0033619; GO:0033630; GO:0035799; GO:0042493; GO:0042551; GO:0043025; GO:0043235; GO:0045121; GO:0045793; GO:0045893; GO:0048265; GO:0048484; GO:0050770; GO:0060041; GO:0060384; GO:0061146; GO:0071300; GO:0072300; GO:1903263; GO:2001241 0 0 0 PF00028;PF07714; O42249 CHOYP_GBLP.1.7 m.4943 sp GBLP_ORENI 82.99 194 33 0 6 199 1 194 1.89E-120 348 GBLP_ORENI reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 317 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:2000114; GO:2000543 0 0 0 PF00400; O42329 CHOYP_ACPR.1.1 m.14237 sp GNRR2_CLAGA 33.945 327 208 4 13 337 51 371 1.89E-61 204 GNRR2_CLAGA reviewed Gonadotropin-releasing hormone II receptor (GnRH II receptor) (GnRH-II-R) (Type II GnRH receptor) 0 Clarias gariepinus (North African catfish) (Silurus gariepinus) 379 0 GO:0004968; GO:0005886; GO:0016021 0 0 0 PF00001; O43301 CHOYP_LOC100372773.3.9 m.31935 sp HS12A_HUMAN 28.299 629 368 19 24 582 57 672 1.89E-66 232 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75095 CHOYP_MEGF6.43.59 m.47502 sp MEGF6_HUMAN 38.202 445 246 18 2 440 838 1259 1.89E-58 210 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P05400 CHOYP_LOC100640973.1.1 m.11258 sp POL_CERV 26.738 374 243 14 117 482 298 648 1.89E-12 73.6 POL_CERV reviewed Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Carnation etched ring virus (CERV) 659 0 GO:0003964; GO:0004190; GO:0004519 0 0 0 PF02160;PF00078; P10079 CHOYP_LOC100632098.5.13 m.23446 sp FBP1_STRPU 53.561 351 162 1 171 520 169 519 1.89E-109 368 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P13944 CHOYP_LOC101064472.1.1 m.66819 sp COCA1_CHICK 34.911 169 103 4 12 177 152 316 1.89E-26 108 COCA1_CHICK reviewed Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) 3124 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00041;PF00092; P20374 CHOYP_COX1.4.15 m.22018 sp COX1_APILI 60.645 310 120 1 2 309 138 447 1.89E-137 402 COX1_APILI reviewed Cytochrome c oxidase subunit 1 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide I) COI Apis mellifera ligustica (Common honeybee) (Italian honeybee) 521 aerobic respiration [GO:0009060]; oxidative phosphorylation [GO:0006119] GO:0004129; GO:0005506; GO:0005743; GO:0006119; GO:0009060; GO:0016021; GO:0020037; GO:0070469 PATHWAY: Energy metabolism; oxidative phosphorylation. 0 0 PF00115; P29070 CHOYP_PP1B.3.3 m.53677 sp CHS1_NEUCR 26.225 408 222 14 863 1194 374 778 1.89E-20 102 CHS1_NEUCR reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) (Class-III chitin synthase 3) chs-1 B11H24.170 NCU03611 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 917 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0071555 0 0 0 PF01644;PF08407; P40199 CHOYP_CEACAM5.5.5 m.53815 sp CEAM6_HUMAN 27.586 203 114 8 165 356 104 284 1.89E-06 54.7 CEAM6_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c) CEACAM6 NCA Homo sapiens (Human) 344 cell-cell signaling [GO:0007267]; leukocyte migration [GO:0050900]; signal transduction [GO:0007165] GO:0005615; GO:0005886; GO:0005887; GO:0007165; GO:0007267; GO:0031225; GO:0050900 0 0 0 PF13895;PF07686; P49025 CHOYP_CIT.2.2 m.51130 sp CTRO_MOUSE 29.102 1536 898 44 472 1857 433 1927 1.89E-152 523 CTRO_MOUSE reviewed "Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Rho-interacting, serine/threonine-protein kinase 21)" Cit Crik Mus musculus (Mouse) 2055 cytokinesis [GO:0000910]; dendrite development [GO:0016358]; generation of neurons [GO:0048699]; intracellular signal transduction [GO:0035556]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic nuclear division [GO:0007067]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of cytokinesis [GO:0032467]; spermatogenesis [GO:0007283] GO:0000070; GO:0000910; GO:0001726; GO:0004674; GO:0005524; GO:0005737; GO:0005773; GO:0005829; GO:0007067; GO:0007091; GO:0007283; GO:0015629; GO:0016020; GO:0016358; GO:0030165; GO:0032467; GO:0035556; GO:0045665; GO:0046872; GO:0048699; GO:0050774; GO:0097110 0 0 0 PF00780;PF00169;PF00069; P51905 CHOYP_LOC101067849.1.1 m.38734 sp SC6A4_DROME 48.8 125 58 2 1 124 130 249 1.89E-36 134 SC6A4_DROME reviewed Sodium-dependent serotonin transporter (5HT transporter) (5HTT) (Cocaine-sensitive serotonin transporter) (dSERT1) SerT CG4545 Drosophila melanogaster (Fruit fly) 622 chemical synaptic transmission [GO:0007268]; monoamine transport [GO:0015844]; phagocytosis [GO:0006909]; serotonin transport [GO:0006837]; serotonin uptake [GO:0051610] GO:0005261; GO:0005328; GO:0005886; GO:0005887; GO:0006837; GO:0006909; GO:0007268; GO:0008504; GO:0015222; GO:0015844; GO:0030424; GO:0043679; GO:0046872; GO:0051610; GO:0098793 0 0 0 PF00209; P55210 CHOYP_LOC100331324.2.3 m.40325 sp CASP7_HUMAN 29.434 265 138 11 12 257 67 301 1.89E-19 89 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P55918 CHOYP_LOC100562636.1.1 m.48658 sp MFAP4_BOVIN 45.455 231 117 5 39 261 25 254 1.89E-58 189 MFAP4_BOVIN reviewed Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) 255 cell adhesion [GO:0007155]; cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; regulation of collagen metabolic process [GO:0010712]; UV protection [GO:0009650] GO:0001527; GO:0007155; GO:0009650; GO:0010712; GO:0031012; GO:0043206; GO:0048251; GO:0070062; GO:0071493; GO:0071953 0 0 0 PF00147; P59222 CHOYP_PEAR1.16.16 m.65594 sp SREC2_MOUSE 40 135 76 4 185 317 227 358 1.89E-17 86.3 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P82596 CHOYP_LOC100371822.2.2 m.27845 sp PLC_HALLA 26.563 128 80 3 1 123 19 137 1.89E-09 55.5 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q03601 CHOYP_LOC656122.1.1 m.882 sp NHL1_CAEEL 44.304 316 171 4 717 1031 663 974 1.89E-76 274 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q04164 CHOYP_VWCE.1.3 m.5007 sp SAS_DROME 26.523 279 154 13 142 411 534 770 1.89E-06 55.1 SAS_DROME reviewed Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) 1693 axon guidance [GO:0007411]; instar larval development [GO:0002168] GO:0002168; GO:0004872; GO:0005887; GO:0007411; GO:0016324 0 0 0 PF00041; Q05A80 CHOYP_LOC100693208.4.8 m.5114 sp CAPR2_MOUSE 30.597 134 81 6 140 268 902 1028 1.89E-06 52.4 CAPR2_MOUSE reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) 1031 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q12955 CHOYP_TVAG_168010.24.45 m.52923 sp ANK3_HUMAN 30.798 789 482 5 110 868 61 815 1.89E-113 386 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q1XA76 CHOYP_LOC100894064.1.1 m.33225 sp ASIC1_CHICK 27.342 523 296 15 90 593 22 479 1.89E-54 196 ASIC1_CHICK reviewed "Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal)" ASIC1 ACCN2 Gallus gallus (Chicken) 527 associative learning [GO:0008306]; calcium ion transmembrane transport [GO:0070588]; cellular response to pH [GO:0071467]; memory [GO:0007613]; negative regulation of neurotransmitter secretion [GO:0046929]; protein homotrimerization [GO:0070207]; regulation of membrane potential [GO:0042391]; response to acidic pH [GO:0010447]; sensory perception of sour taste [GO:0050915]; sodium ion transmembrane transport [GO:0035725] GO:0005887; GO:0007613; GO:0008306; GO:0010447; GO:0022839; GO:0035725; GO:0042391; GO:0044736; GO:0045202; GO:0046929; GO:0050915; GO:0070207; GO:0070588; GO:0071467 0 0 0 PF00858; Q3KRG3 CHOYP_BRAFLDRAFT_215413.1.1 m.2004 sp TSR2_DANRE 36.683 199 103 3 6 200 2 181 1.89E-34 124 TSR2_DANRE reviewed Pre-rRNA-processing protein TSR2 homolog tsr2 dt1p1a10l zgc:109784 Danio rerio (Zebrafish) (Brachydanio rerio) 181 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" GO:0000462; GO:0005634 0 0 0 PF10273; Q3TTI8 CHOYP_BRAFLDRAFT_69423.1.2 m.10728 sp YL021_MOUSE 30.319 188 117 3 8 195 40 213 1.89E-19 89.4 YL021_MOUSE reviewed Uncharacterized protein ENSP00000372125 homolog 0 Mus musculus (Mouse) 308 0 0 0 0 0 PF15046; Q4J781 CHOYP_LOC408643.1.1 m.50154 sp ADH_SULAC 25.356 351 198 14 87 399 20 344 1.89E-15 80.5 ADH_SULAC reviewed NAD-dependent alcohol dehydrogenase (EC 1.1.1.1) adh Saci_2057 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 344 0 GO:0004022; GO:0008270 0 0 0 PF08240;PF00107; Q4R8Z2 CHOYP_LOC100197944.1.1 m.22119 sp RL13A_MACFA 64.444 180 64 0 7 186 7 186 1.89E-87 258 RL13A_MACFA reviewed 60S ribosomal protein L13a RPL13A QtsA-11103 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934; GO:0017148; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q504Y0 CHOYP_SLC39A4.1.1 m.4539 sp S39AC_HUMAN 36.391 327 172 8 1 308 362 671 1.89E-54 191 S39AC_HUMAN reviewed Zinc transporter ZIP12 (LIV-1 subfamily of ZIP zinc transporter 8) (LZT-Hs8) (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) SLC39A12 ZIP12 Homo sapiens (Human) 691 cellular zinc ion homeostasis [GO:0006882]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; signal transduction [GO:0007165]; zinc II ion transmembrane import [GO:0071578] GO:0005385; GO:0005887; GO:0006882; GO:0007165; GO:0010975; GO:0031113; GO:0048471; GO:0071578; GO:1903561 0 0 0 PF02535; Q52M93 CHOYP_LOC571721.1.3 m.36443 sp Z585B_HUMAN 30.888 518 286 9 366 858 270 740 1.89E-64 234 Z585B_HUMAN reviewed Zinc finger protein 585B (zinc finger protein 41-like protein) ZNF585B Homo sapiens (Human) 769 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q54KD0 CHOYP_LOC100374574.1.1 m.36494 sp Y7407_DICDI 22.378 715 466 22 96 764 650 1321 1.89E-27 124 Y7407_DICDI reviewed TPR repeat-containing protein DDB_G0287407 DDB_G0287407 Dictyostelium discoideum (Slime mold) 1663 0 0 0 0 0 PF13271; Q5HZB6 CHOYP_CLASR.1.2 m.27688 sp CLASR_RAT 58.997 339 125 3 1 326 1 338 1.89E-103 333 CLASR_RAT reviewed "CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16)" Clasrp Sfrs16 Rattus norvegicus (Rat) 668 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005634; GO:0006397; GO:0008380 0 0 0 PF09750; Q5R7K4 CHOYP_LOC100642024.2.2 m.49266 sp PCMD2_PONAB 63.74 262 93 1 1 260 1 262 1.89E-120 365 PCMD2_PONAB reviewed Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 PCMTD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 361 0 GO:0004719; GO:0005737 0 0 0 0 Q5RAA9 CHOYP_NIPSNAP3A-B.1.1 m.62397 sp NPS3A_PONAB 32.719 217 107 6 32 215 37 247 1.89E-29 112 NPS3A_PONAB reviewed Protein NipSnap homolog 3A (NipSnap3A) NIPSNAP3A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 247 0 GO:0005634; GO:0005829 0 0 0 PF07978; Q5XF90 CHOYP_ATP13A3.1.1 m.41424 sp AT134_MOUSE 35.443 79 49 1 14 90 8 86 1.89E-09 56.6 AT134_MOUSE reviewed Probable cation-transporting ATPase 13A4 (EC 3.6.3.-) (P5-ATPase isoform 4) Atp13a4 Mus musculus (Mouse) 1193 cellular calcium ion homeostasis [GO:0006874] GO:0005388; GO:0005524; GO:0005789; GO:0005887; GO:0006874; GO:0019829; GO:0046872 0 0 0 PF00690;PF00122;PF12409; Q62730 CHOYP_ISCW_ISCW010271.1.1 m.22595 sp DHB2_RAT 51.786 56 25 1 56 111 80 133 1.89E-10 59.3 DHB2_RAT reviewed Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 2) (17-beta-HSD 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) Hsd17b2 Edh17b2 Rattus norvegicus (Rat) 381 androgen biosynthetic process [GO:0006702]; bone development [GO:0060348]; cellular response to metal ion [GO:0071248]; estrogen biosynthetic process [GO:0006703]; steroid biosynthetic process [GO:0006694] GO:0004303; GO:0006694; GO:0006702; GO:0006703; GO:0016021; GO:0043231; GO:0047035; GO:0060348; GO:0071248 0 0 0 PF00106; Q68CP4 CHOYP_HGSNAT.2.2 m.43220 sp HGNAT_HUMAN 39.394 627 339 15 18 623 54 660 1.89E-141 429 HGNAT_HUMAN reviewed Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) HGSNAT TMEM76 Homo sapiens (Human) 663 glycosaminoglycan catabolic process [GO:0006027]; lysosomal transport [GO:0007041]; protein oligomerization [GO:0051259] GO:0005765; GO:0006027; GO:0007041; GO:0015019; GO:0016021; GO:0016746; GO:0051259 0 0 0 PF07786; Q6A098 CHOYP_LOC584318.1.1 m.35309 sp SBP2L_MOUSE 50.245 408 170 10 569 961 474 863 1.89E-103 356 SBP2L_MOUSE reviewed Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) Secisbp2l Kiaa0256 Mus musculus (Mouse) 1086 0 GO:0044822 0 0 0 PF01248; Q6DDL7 CHOYP_NEMVEDRAFT_V1G110922.1.1 m.23454 sp UN93A_XENLA 49.49 196 95 2 31 225 4 196 1.89E-60 201 UN93A_XENLA reviewed Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) 460 0 GO:0016021 0 0 cd06174; PF05978; Q6P3B9 CHOYP_LOC100164385.1.1 m.48407 sp RBFA_MOUSE 25.455 220 131 7 17 213 28 237 1.89E-08 59.7 RBFA_MOUSE reviewed "Putative ribosome-binding factor A, mitochondrial" Rbfa Mus musculus (Mouse) 350 rRNA processing [GO:0006364] GO:0005739; GO:0006364 0 0 0 PF02033; Q71V39 CHOYP_EF1A2.3.3 m.57363 sp EF1A2_RABIT 92.373 118 9 0 1 118 1 118 1.89E-75 233 EF1A2_RABIT reviewed Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) EEF1A2 Oryctolagus cuniculus (Rabbit) 463 0 GO:0003746; GO:0003924; GO:0005525; GO:0005634; GO:0005737 0 0 0 PF03144;PF03143; Q7L2H7 CHOYP_SYCC.1.1 m.11416 sp EIF3M_HUMAN 52.8 375 173 2 1 375 1 371 1.89E-141 409 EIF3M_HUMAN reviewed Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1) EIF3M HFLB5 PCID1 GA17 PNAS-125 Homo sapiens (Human) 374 cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0002183; GO:0003743; GO:0005829; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290; GO:0071541 0 0 0 PF01399; Q86YF9 CHOYP_LOC100375191.2.2 m.58745 sp DZIP1_HUMAN 37.966 295 159 8 39 316 58 345 1.89E-48 189 DZIP1_HUMAN reviewed Zinc finger protein DZIP1 (DAZ-interacting protein 1/2) DZIP1 DZIP DZIP2 KIAA0996 Homo sapiens (Human) 867 cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; establishment of protein localization [GO:0045184]; germ cell development [GO:0007281]; multicellular organism development [GO:0007275]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283] GO:0005634; GO:0005654; GO:0005737; GO:0005814; GO:0005815; GO:0007224; GO:0007275; GO:0007281; GO:0007283; GO:0036064; GO:0042384; GO:0045184; GO:0046872; GO:0051220; GO:0097539 0 0 0 PF13815; Q8BTN6 CHOYP_LENG9.1.1 m.24496 sp LENG9_MOUSE 48.544 103 49 2 148 246 50 152 1.89E-24 109 LENG9_MOUSE reviewed Leukocyte receptor cluster member 9 Leng9 Mus musculus (Mouse) 485 mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0046872; GO:0098779; GO:0098792 0 0 0 PF10469;PF04457;PF00642; Q8C436 CHOYP_METTL21D.1.1 m.1317 sp MT21D_MOUSE 50.952 210 98 4 7 212 15 223 1.89E-71 219 MT21D_MOUSE reviewed Protein-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase) Vcpkmt Gm71 Mettl21d Mus musculus (Mouse) 228 peptidyl-lysine trimethylation [GO:0018023] GO:0005737; GO:0016279; GO:0018023 0 0 0 PF10294; Q8CHQ0 CHOYP_NEMVEDRAFT_V1G210610.1.2 m.30151 sp FBX4_MOUSE 28.483 323 197 6 82 370 60 382 1.89E-41 152 FBX4_MOUSE reviewed F-box only protein 4 Fbxo4 Fbx4 Mus musculus (Mouse) 385 aging [GO:0007568]; cellular homeostasis [GO:0019725]; cellular response to ionizing radiation [GO:0071479]; common myeloid progenitor cell proliferation [GO:0035726]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; posttranscriptional regulation of gene expression [GO:0010608]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000209; GO:0000723; GO:0004842; GO:0005737; GO:0006511; GO:0007568; GO:0010608; GO:0016567; GO:0019005; GO:0019725; GO:0031146; GO:0031398; GO:0031648; GO:0035726; GO:0042803; GO:0048147; GO:0061630; GO:0071479; GO:1900181; GO:1902916; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; Q8K2J9 CHOYP_BTBD6.5.6 m.52084 sp BTBD6_MOUSE 33.488 430 274 8 8 432 64 486 1.89E-74 244 BTBD6_MOUSE reviewed BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) 488 0 GO:0000932 0 0 0 PF07707;PF00651;PF08005; Q8K3K9 CHOYP_LOC100616953.2.4 m.50104 sp GIMA4_RAT 36.866 217 133 2 43 259 30 242 1.89E-42 152 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8N187 CHOYP_BRAFLDRAFT_82864.1.1 m.45561 sp CARTF_HUMAN 44.089 406 170 10 167 542 181 559 1.89E-96 316 CARTF_HUMAN reviewed Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24) CARF ALS2CR8 Homo sapiens (Human) 725 cellular response to calcium ion [GO:0071277]; cellular response to potassium ion [GO:0035865]; positive regulation of transcription from RNA polymerase II promoter in response to calcium ion [GO:0061400] GO:0000978; GO:0001077; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005730; GO:0035865; GO:0061400; GO:0071277 0 0 0 PF15299; Q8N2E2 CHOYP_VWDE.4.13 m.26655 sp VWDE_HUMAN 30.862 661 393 18 891 1500 935 1582 1.89E-74 278 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8VDW4 CHOYP_BRAFLDRAFT_115629.1.1 m.43059 sp UBE2W_MOUSE 77.181 149 34 0 11 159 2 150 1.89E-89 260 UBE2W_MOUSE reviewed Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-protein ligase W) Ube2w Mus musculus (Mouse) 151 cellular response to misfolded protein [GO:0071218]; DNA repair [GO:0006281]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005524; GO:0005634; GO:0005737; GO:0006281; GO:0006513; GO:0006515; GO:0031625; GO:0043161; GO:0061630; GO:0061631; GO:0070979; GO:0071218 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q91YD4 CHOYP_TRPM4C.1.3 m.51245 sp TRPM2_MOUSE 25.866 491 289 12 469 917 618 1075 1.89E-39 163 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q921X9 CHOYP_BRAFLDRAFT_207882.1.1 m.351 sp PDIA5_MOUSE 44.318 176 92 3 1 172 186 359 1.89E-46 161 PDIA5_MOUSE reviewed Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) Pdia5 Pdir Mus musculus (Mouse) 517 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005783; GO:0005788; GO:0006457; GO:0034976; GO:0045454 0 0 0 PF00085; Q9CRB3 CHOYP_contig_010354 m.12065 sp HIUH_MOUSE 51.327 113 52 3 23 133 7 118 1.89E-31 111 HIUH_MOUSE reviewed 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein) Urah Mus musculus (Mouse) 118 purine nucleobase metabolic process [GO:0006144]; urate catabolic process [GO:0019628] GO:0005739; GO:0005777; GO:0006144; GO:0016787; GO:0019628; GO:0033971 PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. 0 0 PF00576; Q9CZJ2 CHOYP_BRAFLDRAFT_242762.6.8 m.33006 sp HS12B_MOUSE 27.725 743 345 26 10 682 61 681 1.89E-73 253 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D9B4 CHOYP_CAOG_00801.2.2 m.59017 sp CJ011_MOUSE 50.455 220 108 1 68 287 11 229 1.89E-69 217 CJ011_MOUSE reviewed Leucine-rich repeat-containing protein C10orf11 homolog 0 Mus musculus (Mouse) 229 melanocyte differentiation [GO:0030318] GO:0030318 0 0 0 0 Q9H222 CHOYP_LOC101158719.1.1 m.18680 sp ABCG5_HUMAN 39.2 125 71 1 1 120 521 645 1.89E-20 89 ABCG5_HUMAN reviewed ATP-binding cassette sub-family G member 5 (Sterolin-1) ABCG5 Homo sapiens (Human) 651 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; excretion [GO:0007588]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; response to drug [GO:0042493]; response to ionizing radiation [GO:0010212]; response to nutrient [GO:0007584]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085] GO:0005524; GO:0005886; GO:0007584; GO:0007588; GO:0010212; GO:0010949; GO:0015918; GO:0016324; GO:0017127; GO:0030299; GO:0033344; GO:0042493; GO:0042626; GO:0042632; GO:0043190; GO:0043235; GO:0045796; GO:0046982; GO:0055085 0 0 0 PF01061;PF00005; Q9H5L6 CHOYP_WU_FC28F08.1.1 m.7229 sp THAP9_HUMAN 32.479 117 59 5 6 111 5 112 1.89E-08 59.3 THAP9_HUMAN reviewed DNA transposase THAP9 (EC 2.7.7.-) (THAP domain-containing protein 9) (hTh9) THAP9 Homo sapiens (Human) 903 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, DNA-mediated [GO:0006313]" GO:0004803; GO:0006310; GO:0006313; GO:0015074; GO:0016740; GO:0043565; GO:0046872 0 0 0 PF05485;PF12017; Q9NR55 CHOYP_LOC100375938.1.1 m.47100 sp BATF3_HUMAN 48.438 64 33 0 93 156 40 103 1.89E-09 55.8 BATF3_HUMAN reviewed Basic leucine zipper transcriptional factor ATF-like 3 (B-ATF-3) (21 kDa small nuclear factor isolated from T-cells) (Jun dimerization protein p21SNFT) BATF3 SNFT Homo sapiens (Human) 127 dendritic cell differentiation [GO:0097028]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; response to virus [GO:0009615]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0000978; GO:0001078; GO:0003700; GO:0003714; GO:0005634; GO:0006366; GO:0009615; GO:0043011; GO:0097028 0 0 0 PF00170; Q9NUV9 CHOYP_LOC100692316.1.1 m.32429 sp GIMA4_HUMAN 34.405 311 188 6 53 355 27 329 1.89E-50 174 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9VN14 CHOYP_PHUM_PHUM206760.1.1 m.2726 sp CONT_DROME 31.797 1258 738 26 28 1206 139 1355 1.89E-173 553 CONT_DROME reviewed Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) 1390 axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nerve maturation [GO:0021682]; septate junction assembly [GO:0019991] GO:0005886; GO:0005918; GO:0008366; GO:0019991; GO:0021682; GO:0031225; GO:0045197; GO:0060857; GO:0061343 0 0 0 PF00041;PF00047;PF00059; Q9Y345 CHOYP_SC6A9.3.6 m.18461 sp SC6A5_HUMAN 41.774 620 331 3 733 1352 176 765 1.89E-170 537 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q9Z2G9 CHOYP_LOC100377001.2.2 m.52324 sp HTAI2_MOUSE 45.106 235 123 3 1 230 1 234 1.89E-62 198 HTAI2_MOUSE reviewed Oxidoreductase HTATIP2 (EC 1.1.1.-) Htatip2 Cc3 Tip30 Mus musculus (Mouse) 242 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; nuclear import [GO:0051170]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription from RNA polymerase II promoter during mitosis [GO:0046022]; protein autophosphorylation [GO:0046777]; regulation of angiogenesis [GO:0045765] GO:0001525; GO:0004674; GO:0005635; GO:0005654; GO:0005737; GO:0006915; GO:0016020; GO:0016620; GO:0030154; GO:0043068; GO:0045765; GO:0046022; GO:0046777; GO:0051170; GO:0051287 0 0 0 PF13460; A1Z6E0 CHOYP_LOC752289.1.1 m.53932 sp GUS_DROME 36.765 136 77 3 64 192 97 230 1.90E-18 84 GUS_DROME reviewed Protein gustavus gus CG2944 Drosophila melanogaster (Fruit fly) 279 cuticle pattern formation [GO:0035017]; dorsal appendage formation [GO:0046843]; germ cell development [GO:0007281]; intracellular signal transduction [GO:0035556]; oocyte anterior/posterior axis specification [GO:0007314]; pole cell migration [GO:0007280]; pole plasm assembly [GO:0007315]; positive regulation of protein catabolic process [GO:0045732]; protein localization [GO:0008104]; wing disc morphogenesis [GO:0007472] GO:0005634; GO:0005737; GO:0005938; GO:0007280; GO:0007281; GO:0007314; GO:0007315; GO:0007472; GO:0008104; GO:0031466; GO:0035017; GO:0035556; GO:0045495; GO:0045732; GO:0046843; GO:0048471; GO:0070449 0 0 0 PF07525;PF00622; A4W960 CHOYP_BRAFLDRAFT_91321.3.10 m.21668 sp YMDB_ENT38 38.462 117 72 0 274 390 3 119 1.90E-20 91.3 YMDB_ENT38 reviewed O-acetyl-ADP-ribose deacetylase (EC 3.5.1.-) (Regulator of RNase III activity) ymdB Ent638_1561 Enterobacter sp. (strain 638) 180 negative regulation of ribonuclease activity [GO:0060701]; purine nucleoside metabolic process [GO:0042278] GO:0001883; GO:0008428; GO:0019213; GO:0042278; GO:0060701 0 0 0 PF01661; A6NMZ7 CHOYP_LOC100633041.1.1 m.35429 sp CO6A6_HUMAN 25.562 356 220 14 19 363 200 521 1.90E-12 72.4 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; C8V4D4 CHOYP_LOC100891447.1.1 m.18284 sp GRRA_EMENI 28.455 123 85 3 198 318 320 441 1.90E-08 59.3 GRRA_EMENI reviewed SCF E3 ubiquitin ligase complex F-box protein grrA (F-box and leucine-rich repeat protein grrA) (F-box/LRR-repeat protein grrA) (SCF substrate adapter protein grrA) grrA grr1 AN10516 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 585 ascospore formation [GO:0030437]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to methylmercury [GO:0071406]; mitotic cell cycle arrest in response to pheromone [GO:0000751]; protein polyubiquitination [GO:0000209]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000142; GO:0000209; GO:0000751; GO:0004842; GO:0005634; GO:0006974; GO:0019005; GO:0030437; GO:0031146; GO:0071406 0 0 0 PF12937; O04469 CHOYP_LOC100370167.1.1 m.15539 sp ECI1_ARATH 32.99 194 109 6 57 240 18 200 1.90E-25 103 ECI1_ARATH reviewed "Enoyl-CoA delta isomerase 1, peroxisomal (EC 5.3.3.8) (Delta(3),Delta(2)-enoyl CoA isomerase 1) (AtECI1)" ECI1 At1g65520 F5I14.5 Arabidopsis thaliana (Mouse-ear cress) 240 fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062] GO:0004165; GO:0005777; GO:0006635; GO:0009062 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000305}. 0 0 PF00378; O43303 CHOYP_LOC100373865.2.2 m.64840 sp CP110_HUMAN 43.548 62 35 0 55 116 789 850 1.90E-13 68.6 CP110_HUMAN reviewed Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) CCP110 CEP110 CP110 KIAA0419 Homo sapiens (Human) 1012 centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; ciliary basal body organization [GO:0032053]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of cilium assembly [GO:1902018]; positive regulation of cilium assembly [GO:0045724]; regulation of cytokinesis [GO:0032465] GO:0000086; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0007099; GO:0032053; GO:0032465; GO:0043234; GO:0045724; GO:0051298; GO:1902018 0 0 0 0 O95622 CHOYP_APLA.2.2 m.26672 sp ADCY5_HUMAN 51.902 447 177 4 1 441 344 758 1.90E-148 457 ADCY5_HUMAN reviewed Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (AC5) ADCY5 Homo sapiens (Human) 1261 activation of adenylate cyclase activity [GO:0007190]; activation of protein kinase A activity [GO:0034199]; adenosine receptor signaling pathway [GO:0001973]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; cAMP biosynthetic process [GO:0006171]; cAMP-mediated signaling [GO:0019933]; cellular response to forskolin [GO:1904322]; cellular response to glucagon stimulus [GO:0071377]; locomotory behavior [GO:0007626]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; renal water homeostasis [GO:0003091] GO:0001973; GO:0003091; GO:0004016; GO:0005524; GO:0005622; GO:0005886; GO:0006171; GO:0007189; GO:0007190; GO:0007191; GO:0007193; GO:0007195; GO:0007204; GO:0007626; GO:0008179; GO:0016021; GO:0019933; GO:0034199; GO:0046872; GO:0046982; GO:0050885; GO:0061178; GO:0071377; GO:0072372; GO:1904322 0 0 0 PF16214;PF06327;PF00211; P00543 CHOYP_LOC100879975.1.1 m.22756 sp FES_FSVST 43.631 369 194 8 39 399 110 472 1.90E-96 299 FES_FSVST reviewed Tyrosine-protein kinase transforming protein Fes (EC 2.7.10.2) V-FES Feline sarcoma virus (strain Snyder-Theilen) 477 0 GO:0004715; GO:0005524 0 0 0 PF07714;PF00017; P13944 CHOYP_LOC100639386.2.2 m.26791 sp COCA1_CHICK 34.848 198 125 2 33 228 1186 1381 1.90E-27 120 COCA1_CHICK reviewed Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) 3124 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00041;PF00092; P20273 CHOYP_CD22.4.4 m.66439 sp CD22_HUMAN 24.348 345 219 14 136 466 225 541 1.90E-16 85.9 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P24386 CHOYP_BRAFLDRAFT_123298.1.1 m.483 sp RAE1_HUMAN 39.968 633 344 11 5 619 1 615 1.90E-153 463 RAE1_HUMAN reviewed Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) CHM REP1 TCD Homo sapiens (Human) 653 protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; regulation of apoptotic process [GO:0042981]; small GTPase mediated signal transduction [GO:0007264]; visual perception [GO:0007601] GO:0004663; GO:0005092; GO:0005096; GO:0005829; GO:0005968; GO:0006612; GO:0007264; GO:0007601; GO:0016491; GO:0017137; GO:0018344; GO:0042981 0 0 0 PF00996; P32240 CHOYP_PI2R.1.4 m.23869 sp PE2R4_MOUSE 25.294 340 202 12 20 312 47 381 1.90E-19 92.4 PE2R4_MOUSE reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Ptgerep4 Mus musculus (Mouse) 513 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005887; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0030278; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P55214 CHOYP_XCASPASE-7.3.4 m.49655 sp CASP7_MESAU 28.028 289 139 12 5 274 61 299 1.90E-18 86.7 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 P86449 CHOYP_LOC100372847.2.4 m.23897 sp TR43C_MOUSE 24.409 254 140 9 24 245 50 283 1.90E-08 59.3 TR43C_MOUSE reviewed Tripartite motif-containing protein 43C Trim43c Mus musculus (Mouse) 446 0 GO:0005622; GO:0008270 0 0 0 PF00097; Q05695 CHOYP_CNTN4.2.2 m.63707 sp L1CAM_RAT 26.055 403 243 19 61 436 52 426 1.90E-26 119 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q0IH40 CHOYP_DGRI_GH24435.1.1 m.30173 sp DNLZ_XENLA 58.667 75 30 1 107 180 86 160 1.90E-26 102 DNLZ_XENLA reviewed DNL-type zinc finger protein (mtHsp70-escort protein) dnlz Xenopus laevis (African clawed frog) 188 0 GO:0005739; GO:0008270 0 0 0 PF05180; Q14684 CHOYP_RRP1B.1.1 m.21811 sp RRP1B_HUMAN 37.685 337 169 5 1 296 1 337 1.90E-64 231 RRP1B_HUMAN reviewed Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B) RRP1B KIAA0179 Homo sapiens (Human) 758 negative regulation of phosphatase activity [GO:0010923]; rRNA processing [GO:0006364] GO:0000791; GO:0000792; GO:0005634; GO:0005730; GO:0005829; GO:0006364; GO:0010923; GO:0030687; GO:0030688; GO:0044822 0 0 0 PF05997; Q148K5 CHOYP_LOC100369977.1.1 m.33592 sp PX11B_BOVIN 27.237 257 166 4 12 250 5 258 1.90E-34 127 PX11B_BOVIN reviewed Peroxisomal membrane protein 11B (Peroxin-11B) (Peroxisomal biogenesis factor 11B) PEX11B Bos taurus (Bovine) 258 peroxisome fission [GO:0016559]; protein homooligomerization [GO:0051260]; regulation of peroxisome size [GO:0044375] GO:0005778; GO:0005779; GO:0016559; GO:0043234; GO:0044375; GO:0051260; GO:0070062 0 0 0 PF05648; Q2NKT1 CHOYP_LOC100372995.1.3 m.15529 sp PROF4_BOVIN 47.826 115 59 1 36 149 14 128 1.90E-33 117 PROF4_BOVIN reviewed Profilin-4 PFN4 Bos taurus (Bovine) 129 sequestering of actin monomers [GO:0042989] GO:0003785; GO:0005938; GO:0008289; GO:0015629; GO:0042989 0 0 0 PF00235; Q2PC93 CHOYP_LOC100209306.1.1 m.22204 sp SSPO_CHICK 45.614 57 29 1 430 486 3642 3696 1.90E-08 62 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q2TBK2 CHOYP_DGRI_GH19122.1.1 m.1378 sp RM09_BOVIN 33.898 177 108 6 32 204 55 226 1.90E-16 80.5 RM09_BOVIN reviewed "39S ribosomal protein L9, mitochondrial (L9mt) (MRP-L9)" MRPL9 Bos taurus (Bovine) 268 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005743; GO:0005840; GO:0006412; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF01281; Q32LB9 CHOYP_LOC100533217.1.1 m.13354 sp NOA1_BOVIN 34.142 577 325 15 157 696 128 686 1.90E-88 294 NOA1_BOVIN reviewed Nitric oxide-associated protein 1 NOA1 Bos taurus (Bovine) 694 apoptotic process [GO:0006915]; mitochondrial translation [GO:0032543]; regulation of cell death [GO:0010941]; regulation of cellular respiration [GO:0043457]; ribosome biogenesis [GO:0042254] GO:0003924; GO:0005525; GO:0005739; GO:0005743; GO:0006915; GO:0010941; GO:0032543; GO:0042254; GO:0043457 0 0 0 PF01926; Q32P85 CHOYP_LOC100370139.3.4 m.58156 sp DLRB2_BOVIN 85.366 82 12 0 1 82 1 82 1.90E-47 150 DLRB2_BOVIN reviewed "Dynein light chain roadblock-type 2 (Dynein light chain 2B, cytoplasmic)" DYNLRB2 DNLC2B Bos taurus (Bovine) 96 microtubule-based movement [GO:0007018]; transport [GO:0006810] GO:0003774; GO:0005737; GO:0005868; GO:0005874; GO:0006810; GO:0007018 0 0 0 PF03259; Q3UPF5 CHOYP_PHUM_PHUM577920.1.1 m.5208 sp ZCCHV_MOUSE 27.143 140 84 6 1 135 92 218 1.90E-08 56.6 ZCCHV_MOUSE reviewed Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) Zc3hav1 Mus musculus (Mouse) 946 cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of ATPase activity [GO:0032781]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; regulation of defense response to virus by host [GO:0050691]; response to virus [GO:0009615]; suppression by virus of host molecular function [GO:0039507] GO:0003950; GO:0005634; GO:0005737; GO:0005764; GO:0005770; GO:0005794; GO:0009615; GO:0017151; GO:0032481; GO:0032727; GO:0032728; GO:0032781; GO:0039507; GO:0043123; GO:0044822; GO:0045071; GO:0045087; GO:0046872; GO:0050691; GO:0051607; GO:0061014; GO:0071360; GO:1900246 0 0 0 PF00644;PF02825; Q4QQT0 CHOYP_LOC100371939.1.1 m.9664 sp RUSD4_RAT 38.567 293 171 6 580 865 75 365 1.90E-60 213 RUSD4_RAT reviewed RNA pseudouridylate synthase domain-containing protein 4 Rpusd4 Rattus norvegicus (Rat) 377 tRNA pseudouridine synthesis [GO:0031119] GO:0005739; GO:0009982; GO:0031119; GO:0044822 0 0 0 PF00849; Q58DA1 CHOYP_LOC100371058.3.3 m.36497 sp SPEF1_BOVIN 35.87 276 121 7 18 289 1 224 1.90E-42 149 SPEF1_BOVIN reviewed Sperm flagellar protein 1 SPEF1 Bos taurus (Bovine) 236 0 GO:0005737; GO:0005930; GO:0031514 0 0 0 PF06294; Q5E9S4 CHOYP_LOC101064182.1.1 m.8320 sp AT2L1_BOVIN 50.115 433 209 3 9 434 8 440 1.90E-160 466 AT2L1_BOVIN reviewed Ethanolamine-phosphate phospho-lyase (EC 4.2.3.2) (Alanine--glyoxylate aminotransferase 2-like 1) ETNPPL AGXT2L1 Bos taurus (Bovine) 497 0 GO:0005739; GO:0008483; GO:0030170; GO:0042802; GO:0050459 0 0 cd00610; PF00202; Q5HZI9 CHOYP_SLC25A51.1.1 m.23568 sp S2551_MOUSE 46.212 264 141 1 12 275 33 295 1.90E-80 248 S2551_MOUSE reviewed Solute carrier family 25 member 51 (Mitochondrial carrier triple repeat protein 1) Slc25a51 Mcart1 Mus musculus (Mouse) 298 translation [GO:0006412]; transport [GO:0006810] GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0006810; GO:0016021 0 0 0 PF00153; Q5PQS5 CHOYP_contig_037157 m.41850 sp CYYR1_RAT 30.303 165 82 8 19 161 5 158 1.90E-06 48.5 CYYR1_RAT reviewed Cysteine and tyrosine-rich protein 1 Cyyr1 Rattus norvegicus (Rat) 165 0 GO:0016021 0 0 0 PF10873; Q5RD58 CHOYP_BRAFLDRAFT_283171.1.1 m.33290 sp CL004_PONAB 45.656 541 286 5 8 544 14 550 1.90E-173 504 CL004_PONAB reviewed Protein C12orf4 homolog 0 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 552 regulation of mast cell degranulation [GO:0043304] GO:0005737; GO:0043304 0 0 0 PF10154; Q6DGA6 CHOYP_NEMVEDRAFT_V1G235970.1.1 m.34141 sp ALLC_DANRE 55.376 372 160 3 13 380 14 383 1.90E-156 450 ALLC_DANRE reviewed Allantoicase (EC 3.5.3.4) (Allantoate amidinohydrolase) allc si:ch211-284k10.3 zgc:91799 Danio rerio (Zebrafish) (Brachydanio rerio) 395 allantoin catabolic process [GO:0000256]; purine nucleobase metabolic process [GO:0006144] GO:0000256; GO:0004037; GO:0006144 PATHWAY: Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1. 0 0 PF03561; Q7SXL7 CHOYP_FL2D.1.1 m.62439 sp FL2D_DANRE 49.43 263 126 4 7 267 8 265 1.90E-75 243 FL2D_DANRE reviewed Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) wtap ch211-195e3.2 zgc:66202 Danio rerio (Zebrafish) (Brachydanio rerio) 423 "cell cycle [GO:0007049]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" GO:0000381; GO:0005634; GO:0006397; GO:0007049; GO:0008380; GO:0016607; GO:0036396; GO:0042981; GO:0080009 0 0 0 PF17098; Q8HXX6 CHOYP_BRAFLDRAFT_124972.4.5 m.26870 sp SAP3_MACFA 30.769 182 113 7 1 174 10 186 1.90E-23 94.7 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8IZR5 CHOYP_LOC592857.1.1 m.62835 sp CKLF4_HUMAN 32.24 183 114 6 2 178 24 202 1.90E-14 72 CKLF4_HUMAN reviewed CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4) CMTM4 CKLFSF4 Homo sapiens (Human) 234 chemotaxis [GO:0006935] GO:0005615; GO:0006935; GO:0016021 0 0 0 PF01284; Q8JZZ7 CHOYP_TRIADDRAFT_54306.1.1 m.37298 sp AGRL2_MOUSE 26.895 409 231 21 177 543 462 844 1.90E-21 102 AGRL2_MOUSE reviewed Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin-2) Adgrl2 Kiaa0786 Lphn2 Mus musculus (Mouse) 1487 cell surface receptor signaling pathway [GO:0007166]; positive regulation of synapse assembly [GO:0051965] GO:0004930; GO:0007166; GO:0016021; GO:0030246; GO:0051965 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q8N4L2 CHOYP_LOC100368816.1.2 m.39723 sp TM55A_HUMAN 45.882 255 116 5 26 265 3 250 1.90E-71 223 TM55A_HUMAN reviewed "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)" TMEM55A Homo sapiens (Human) 257 phosphatidylinositol dephosphorylation [GO:0046856] GO:0005765; GO:0016021; GO:0031902; GO:0034597; GO:0046856 0 0 0 PF09788; Q8QGW7 CHOYP_LOC100209491.2.2 m.15610 sp LITAF_CHICK 41.216 148 76 5 117 259 7 148 1.90E-20 87.8 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8R151 CHOYP_LOC100371500.4.7 m.34025 sp ZNFX1_MOUSE 29.234 496 290 15 171 636 326 790 1.90E-48 191 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R3S2 CHOYP_TSN33.1.3 m.4158 sp TSN33_MOUSE 36.972 284 157 9 15 295 14 278 1.90E-54 181 TSN33_MOUSE reviewed Tetraspanin-33 (Tspan-33) (Penumbra) (mPen) (Proerythroblast new membrane) Tspan33 Pen Mus musculus (Mouse) 283 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005886; GO:0005887; GO:0007166; GO:0009986; GO:0019899; GO:0045747; GO:0051604; GO:0090002; GO:0097197 0 0 0 PF00335; Q8TC07 CHOYP_BRAFLDRAFT_95612.1.1 m.46830 sp TBC15_HUMAN 48.765 162 78 3 1 159 232 391 1.90E-46 164 TBC15_HUMAN reviewed TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) TBC1D15 Homo sapiens (Human) 691 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of GTPase activity [GO:0043087]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0005737; GO:0005739; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0043087; GO:0070062; GO:0090630 0 0 0 PF12068;PF00566; Q92193 CHOYP_ACT.13.27 m.39346 sp ACT_CRAVI 94.309 123 7 0 12 134 22 144 1.90E-79 239 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q95VY2 CHOYP_LOC100699383.1.1 m.63490 sp TCTP_BRABE 51.149 174 80 3 1 174 1 169 1.90E-56 177 TCTP_BRABE reviewed Translationally-controlled tumor protein homolog (TCTP) 0 Branchiostoma belcheri (Amphioxus) 169 0 GO:0005737 0 0 0 PF00838; Q95VY2 CHOYP_MLE.3.9 m.28781 sp TCTP_BRABE 51.149 174 80 3 1 174 1 169 1.90E-56 177 TCTP_BRABE reviewed Translationally-controlled tumor protein homolog (TCTP) 0 Branchiostoma belcheri (Amphioxus) 169 0 GO:0005737 0 0 0 PF00838; Q95ZS2 CHOYP_LOC661439.1.1 m.25169 sp TDC1_CAEEL 46.991 349 159 4 1 326 307 652 1.90E-110 339 TDC1_CAEEL reviewed Tyrosine decarboxylase (EC 4.1.1.25) tdc-1 K01C8.3 Caenorhabditis elegans 705 cellular amino acid metabolic process [GO:0006520]; octopamine biosynthetic process [GO:0006589] GO:0004837; GO:0005737; GO:0006520; GO:0006589; GO:0030170; GO:0030424; GO:0043025; GO:0043204 0 0 0 PF00282; Q96MM6 CHOYP_BRAFLDRAFT_208197.2.21 m.9816 sp HS12B_HUMAN 39.044 502 258 8 36 490 54 554 1.90E-111 347 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96NA8 CHOYP_LOC101067320.2.2 m.49586 sp TSNA1_HUMAN 32.407 108 70 2 5 110 122 228 1.90E-09 57.8 TSNA1_HUMAN reviewed t-SNARE domain-containing protein 1 TSNARE1 Homo sapiens (Human) 513 intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000149; GO:0005484; GO:0006886; GO:0006906; GO:0012505; GO:0016021; GO:0031201; GO:0048278 0 0 0 PF13873;PF05739; Q96RI1 CHOYP_NR1H4.1.2 m.19998 sp NR1H4_HUMAN 33.158 380 216 15 282 657 137 482 1.90E-34 140 NR1H4_HUMAN reviewed Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) NR1H4 BAR FXR HRR1 RIP14 Homo sapiens (Human) 486 bile acid and bile salt transport [GO:0015721]; bile acid metabolic process [GO:0008206]; bile acid signaling pathway [GO:0038183]; cellular response to fatty acid [GO:0071398]; cellular response to organonitrogen compound [GO:0071417]; cellular triglyceride homeostasis [GO:0035356]; digestive tract development [GO:0048565]; histone H3-R17 methylation [GO:0034971]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-17 secretion [GO:0072615]; intracellular bile acid receptor signaling pathway [GO:0038185]; intracellular receptor signaling pathway [GO:0030522]; negative regulation of apoptotic process [GO:0043066]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma secretion [GO:1902714]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor secretion [GO:1904468]; nitrogen catabolite activation of transcription from RNA polymerase II promoter [GO:0001080]; Notch signaling pathway [GO:0007219]; positive regulation of ammonia assimilation cycle [GO:2001250]; positive regulation of glutamate metabolic process [GO:2000213]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of carbohydrate metabolic process [GO:0006109]; regulation of cholesterol metabolic process [GO:0090181]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of low-density lipoprotein particle clearance [GO:0010988]; regulation of urea metabolic process [GO:0034255]; response to glucose [GO:0009749]; response to lipopolysaccharide [GO:0032496]; signal transduction [GO:0007165]; toll-like receptor 4 signaling pathway [GO:0034142]; transcription initiation from RNA polymerase II promoter [GO:0006367] GO:0000122; GO:0000980; GO:0001077; GO:0001080; GO:0001190; GO:0003700; GO:0003705; GO:0003707; GO:0003713; GO:0003714; GO:0004879; GO:0004887; GO:0005654; GO:0005719; GO:0006109; GO:0006367; GO:0006954; GO:0007165; GO:0007219; GO:0008206; GO:0008270; GO:0009749; GO:0010988; GO:0015721; GO:0016922; GO:0030522; GO:0032052; GO:0032496; GO:0034142; GO:0034255; GO:0034971; GO:0035356; GO:0038181; GO:0038183; GO:0038185; GO:0042277; GO:0043066; GO:0043124; GO:0043565; GO:0045087; GO:0045944; GO:0048565; GO:0061178; GO:0070857; GO:0070858; GO:0071398; GO:0071417; GO:0072615; GO:0090181; GO:1902122; GO:1902714; GO:1904468; GO:2000213; GO:2001250 0 0 0 PF00104;PF00105; Q9ESN6 CHOYP_LOC100369333.23.32 m.39423 sp TRIM2_MOUSE 25.352 213 132 7 341 541 534 731 1.90E-08 60.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM3.1.58 m.670 sp TRIM2_MOUSE 30.137 219 132 10 53 262 536 742 1.90E-13 73.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H0J9 CHOYP_ZC3HDC1L.1.1 m.44413 sp PAR12_HUMAN 28.076 634 370 27 646 1238 89 677 1.90E-48 189 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9HCF6 CHOYP_TRPM3.4.7 m.26588 sp TRPM3_HUMAN 22.91 873 481 27 1 714 248 1087 1.90E-49 191 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9I7U4 CHOYP_PHUM_PHUM226120.5.7 m.43583 sp TITIN_DROME 43.421 76 43 0 2 77 16521 16596 1.90E-15 73.6 TITIN_DROME reviewed Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) 18141 cell division [GO:0051301]; locomotion [GO:0040011]; mesoderm development [GO:0007498]; mitotic chromosome condensation [GO:0007076]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; regulation of hemocyte proliferation [GO:0035206]; sarcomere organization [GO:0045214]; sensory perception of pain [GO:0019233]; sister chromatid cohesion [GO:0007062]; skeletal muscle tissue development [GO:0007519]; somatic muscle development [GO:0007525]; visceral muscle development [GO:0007522] GO:0000794; GO:0003779; GO:0005863; GO:0005875; GO:0007062; GO:0007076; GO:0007498; GO:0007517; GO:0007519; GO:0007520; GO:0007522; GO:0007525; GO:0008307; GO:0016203; GO:0019233; GO:0030017; GO:0030018; GO:0031674; GO:0035206; GO:0040011; GO:0045214; GO:0051301 0 0 0 PF06582;PF00041;PF07679;PF00018; Q9P0J7 CHOYP_KCMF1.1.1 m.62675 sp KCMF1_HUMAN 56.886 334 132 4 1 327 1 329 1.90E-122 366 KCMF1_HUMAN reviewed E3 ubiquitin-protein ligase KCMF1 (EC 6.3.2.-) (FGF-induced in gastric cancer) (Potassium channel modulatory factor) (PCMF) (ZZ-type zinc finger-containing protein 1) KCMF1 FIGC ZZZ1 Homo sapiens (Human) 381 0 GO:0008270; GO:0016874 0 0 0 PF05605;PF00569; Q9UKK3 CHOYP_LOC577455.1.1 m.45988 sp PARP4_HUMAN 46.512 301 156 3 3 300 913 1211 1.90E-74 276 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9V4N3 CHOYP_LOC575345.2.2 m.61933 sp CYB5_DROME 46.429 84 45 0 21 104 3 86 1.90E-21 85.1 CYB5_DROME reviewed Cytochrome b5 (CYTB5) Cyt-b5 CG2140 Drosophila melanogaster (Fruit fly) 134 oxidation-reduction process [GO:0055114]; regulation of hemocyte differentiation [GO:0045610]; regulation of hemocyte proliferation [GO:0035206] GO:0005789; GO:0005811; GO:0012505; GO:0016021; GO:0020037; GO:0031090; GO:0035206; GO:0045610; GO:0046872; GO:0055114 0 0 0 PF00173; A0A0R4IBK5 CHOYP_RN213.3.13 m.6068 sp R213A_DANRE 40.441 136 71 4 1 131 4504 4634 1.91E-26 106 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A3KMW7 CHOYP_BRAFLDRAFT_118762.1.1 m.17903 sp MAP10_BOVIN 25.536 560 308 22 25 556 53 531 1.91E-20 100 MAP10_BOVIN reviewed Microtubule-associated protein 10 (Microtubule regulator of 120 KDa) MAP10 Bos taurus (Bovine) 912 cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; mitotic spindle midzone assembly [GO:0051256]; positive regulation of cytokinesis [GO:0032467]; regulation of microtubule-based process [GO:0032886] GO:0005813; GO:0005881; GO:0008017; GO:0030496; GO:0031122; GO:0032467; GO:0032886; GO:0051256; GO:0051301; GO:0097431; GO:1990023 0 0 0 PF14925; A3RLT6 CHOYP_LOC100543980.1.2 m.730 sp RSSA_PINFU 65.591 93 27 5 1 91 198 287 1.91E-23 94.4 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A3RLT6 CHOYP_RSSA.1.10 m.2054 sp RSSA_PINFU 83.959 293 42 5 201 491 1 290 1.91E-165 473 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A4IF63 CHOYP_BRAFLDRAFT_87325.3.11 m.408 sp TRIM2_BOVIN 32.292 96 62 2 187 280 627 721 1.91E-06 52.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B1H369 CHOYP_LOC100373017.1.1 m.15833 sp HDAC8_XENTR 53.846 364 165 2 119 481 7 368 1.91E-149 434 HDAC8_XENTR reviewed Histone deacetylase 8 (HD8) (EC 3.5.1.98) hdac8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 369 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0032041; GO:0046872 0 0 0 PF00850; D2GXS7 CHOYP_LOC100374741.60.83 m.53301 sp TRIM2_AILME 24.06 266 166 7 332 574 492 744 1.91E-14 80.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E1BD59 CHOYP_LOC100636374.1.4 m.5851 sp TRI56_BOVIN 23.891 293 181 9 18 281 19 298 1.91E-15 82.4 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; G5ED84 CHOYP_BACH1.1.17 m.5128 sp KLHL8_CAEEL 27.536 138 92 4 7 137 88 224 1.91E-07 57.8 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O15050 CHOYP_TRNK1.5.6 m.63400 sp TRNK1_HUMAN 44.019 209 107 5 1 207 1549 1749 1.91E-49 175 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15990 CHOYP_HACD2.1.1 m.33345 sp KARG_LIOJA 59.444 180 73 0 17 196 85 264 1.91E-73 228 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O60290 CHOYP_LOC100889557.1.1 m.54866 sp ZN862_HUMAN 23.279 610 403 18 21 613 511 1072 1.91E-29 129 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; O75376 CHOYP_LOC588549.1.2 m.1855 sp NCOR1_HUMAN 54.054 370 156 5 167 523 142 510 1.91E-104 379 NCOR1_HUMAN reviewed Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) NCOR1 KIAA1047 Homo sapiens (Human) 2440 cellular lipid metabolic process [GO:0044255]; cerebellum development [GO:0021549]; circadian rhythm [GO:0007623]; covalent chromatin modification [GO:0016569]; lactation [GO:0007595]; negative regulation of JNK cascade [GO:0046329]; negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cell proliferation [GO:0008284]; regulation of fatty acid transport [GO:2000191]; regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [GO:0072362]; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [GO:0072368]; skeletal muscle tissue development [GO:0007519]; spindle assembly [GO:0051225]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0000790; GO:0001012; GO:0001102; GO:0003682; GO:0003714; GO:0005634; GO:0005654; GO:0005876; GO:0006366; GO:0007519; GO:0007595; GO:0007623; GO:0008284; GO:0016020; GO:0016569; GO:0016922; GO:0017053; GO:0021549; GO:0035257; GO:0042826; GO:0044212; GO:0044255; GO:0046329; GO:0046966; GO:0048471; GO:0051225; GO:0072362; GO:0072368; GO:1903799; GO:2000191 0 0 0 PF15784;PF00249; O96064 CHOYP_MYSP.1.9 m.1095 sp MYSP_MYTGA 77.236 369 83 1 1 369 497 864 1.91E-178 520 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P06603 CHOYP_LOC585338.1.2 m.19089 sp TBA1_DROME 98.387 124 2 0 1 124 36 159 1.91E-84 256 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P10079 CHOYP_LOC100634060.7.37 m.21078 sp FBP1_STRPU 54.491 167 76 0 1 167 349 515 1.91E-52 182 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11179 CHOYP_LOC100689951.1.1 m.56514 sp ODO2_BOVIN 57.921 404 158 3 85 483 59 455 1.91E-148 434 ODO2_BOVIN reviewed "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)" DLST Bos taurus (Bovine) 455 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; tricarboxylic acid cycle [GO:0006099] GO:0004149; GO:0005739; GO:0006099; GO:0033512; GO:0045252 PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6. 0 0 PF00198;PF00364; P17141 CHOYP_BRAFLDRAFT_82362.1.1 m.13505 sp ZFP37_MOUSE 37.154 253 149 4 81 330 310 555 1.91E-45 173 ZFP37_MOUSE reviewed Zinc finger protein 37 (Zfp-37) (Male germ cell-specific zinc finger protein) Zfp37 Zfp-37 Mus musculus (Mouse) 594 "germ cell development [GO:0007281]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0007281; GO:0007283; GO:0008270 0 0 cd07765; PF01352;PF00096;PF13912; P20825 CHOYP_LOC763830.1.1 m.25289 sp POL2_DROME 35.714 518 298 12 567 1067 80 579 1.91E-86 305 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P22856 CHOYP_AT5G03330.1.1 m.36139 sp VL96_IRV1 27.632 152 95 4 164 306 600 745 1.91E-08 61.2 VL96_IRV1 reviewed Putative ubiquitin thioesterase L96 (EC 3.4.19.12) L96 Tipula iridescent virus (TIV) (Insect iridescent virus type 1) 867 "DNA-templated transcription, termination [GO:0006353]; viral release from host cell [GO:0019076]" GO:0003677; GO:0006353; GO:0019076; GO:0036459 0 0 0 PF02338; P23469 CHOYP_PTPRE.3.19 m.22768 sp PTPRE_HUMAN 33.779 598 335 19 844 1403 115 689 1.91E-83 292 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P24862 CHOYP_CCNB.1.2 m.9733 sp CCNB_PATVU 58.029 274 94 7 10 278 1 258 1.91E-96 293 CCNB_PATVU reviewed G2/mitotic-specific cyclin-B 0 Patella vulgata (Common limpet) 408 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134; P35072 CHOYP_LOC101076390.1.1 m.49124 sp TCB1_CAEBR 31.159 276 183 5 71 344 3 273 1.91E-32 125 TCB1_CAEBR reviewed Transposable element Tcb1 transposase (Transposable element Barney transposase) 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; P50429 CHOYP_BRAFLDRAFT_206907.2.11 m.14813 sp ARSB_MOUSE 45.11 317 161 4 1 304 81 397 1.91E-96 298 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; P92177 CHOYP_1433E.1.2 m.3638 sp 1433E_DROME 77.692 260 53 1 1 255 1 260 1.91E-149 420 1433E_DROME reviewed 14-3-3 protein epsilon (Suppressor of Ras1 3-9) 14-3-3epsilon 14-3-3e SR3-9 CG31196 Drosophila melanogaster (Fruit fly) 262 axon guidance [GO:0007411]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint [GO:0000077]; germarium-derived oocyte fate determination [GO:0007294]; imaginal disc development [GO:0007444]; mitotic cell cycle checkpoint [GO:0007093]; mitotic G2 DNA damage checkpoint [GO:0007095]; oocyte microtubule cytoskeleton polarization [GO:0008103]; pole cell migration [GO:0007280]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of growth [GO:0045927]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of growth [GO:0040008]; regulation of mitotic nuclear division [GO:0007088]; response to radiation [GO:0009314]; response to UV [GO:0009411]; wing disc dorsal/ventral pattern formation [GO:0048190] GO:0000077; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005875; GO:0005886; GO:0007088; GO:0007093; GO:0007095; GO:0007280; GO:0007294; GO:0007411; GO:0007444; GO:0008103; GO:0008340; GO:0009314; GO:0009411; GO:0040008; GO:0045172; GO:0045927; GO:0046579; GO:0046982; GO:0048190; GO:0050815; GO:0070374 0 0 0 PF00244; P92177 CHOYP_1433E.2.2 m.63376 sp 1433E_DROME 77.692 260 53 1 1 255 1 260 1.91E-149 420 1433E_DROME reviewed 14-3-3 protein epsilon (Suppressor of Ras1 3-9) 14-3-3epsilon 14-3-3e SR3-9 CG31196 Drosophila melanogaster (Fruit fly) 262 axon guidance [GO:0007411]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint [GO:0000077]; germarium-derived oocyte fate determination [GO:0007294]; imaginal disc development [GO:0007444]; mitotic cell cycle checkpoint [GO:0007093]; mitotic G2 DNA damage checkpoint [GO:0007095]; oocyte microtubule cytoskeleton polarization [GO:0008103]; pole cell migration [GO:0007280]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of growth [GO:0045927]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of growth [GO:0040008]; regulation of mitotic nuclear division [GO:0007088]; response to radiation [GO:0009314]; response to UV [GO:0009411]; wing disc dorsal/ventral pattern formation [GO:0048190] GO:0000077; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005875; GO:0005886; GO:0007088; GO:0007093; GO:0007095; GO:0007280; GO:0007294; GO:0007411; GO:0007444; GO:0008103; GO:0008340; GO:0009314; GO:0009411; GO:0040008; GO:0045172; GO:0045927; GO:0046579; GO:0046982; GO:0048190; GO:0050815; GO:0070374 0 0 0 PF00244; P92177 CHOYP_LOC100901017.2.2 m.20039 sp 1433E_DROME 77.692 260 53 1 1 255 1 260 1.91E-149 420 1433E_DROME reviewed 14-3-3 protein epsilon (Suppressor of Ras1 3-9) 14-3-3epsilon 14-3-3e SR3-9 CG31196 Drosophila melanogaster (Fruit fly) 262 axon guidance [GO:0007411]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint [GO:0000077]; germarium-derived oocyte fate determination [GO:0007294]; imaginal disc development [GO:0007444]; mitotic cell cycle checkpoint [GO:0007093]; mitotic G2 DNA damage checkpoint [GO:0007095]; oocyte microtubule cytoskeleton polarization [GO:0008103]; pole cell migration [GO:0007280]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of growth [GO:0045927]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of growth [GO:0040008]; regulation of mitotic nuclear division [GO:0007088]; response to radiation [GO:0009314]; response to UV [GO:0009411]; wing disc dorsal/ventral pattern formation [GO:0048190] GO:0000077; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005875; GO:0005886; GO:0007088; GO:0007093; GO:0007095; GO:0007280; GO:0007294; GO:0007411; GO:0007444; GO:0008103; GO:0008340; GO:0009314; GO:0009411; GO:0040008; GO:0045172; GO:0045927; GO:0046579; GO:0046982; GO:0048190; GO:0050815; GO:0070374 0 0 0 PF00244; Q06577 CHOYP_C1QL4.5.10 m.28344 sp HP27_TAMSI 30.081 123 81 2 227 345 93 214 1.91E-09 61.6 HP27_TAMSI reviewed Hibernation-associated plasma protein HP-27 (Hibernator-specific blood complex 27 kDa subunit) 0 Tamias sibiricus (Siberian chipmunk) (Eutamias sibiricus) 215 hibernation [GO:0042750] GO:0005576; GO:0005581; GO:0042750 0 0 0 PF00386;PF01391; Q07883 CHOYP_LOC659521.1.1 m.56402 sp GRB2_CHICK 25.962 208 126 9 60 241 8 213 1.91E-07 55.5 GRB2_CHICK reviewed Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) GRB2 Gallus gallus (Chicken) 217 0 GO:0005634; GO:0005737; GO:0005768; GO:0005794 0 0 0 PF00017;PF00018; Q23551 CHOYP_LOC100367089.1.4 m.1393 sp UNC22_CAEEL 52.59 251 111 2 1 250 6310 6553 1.91E-87 290 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q27218 CHOYP_NEMVEDRAFT_V1G205808.1.1 m.35546 sp ACH7_CAEEL 30.794 315 205 7 24 331 34 342 1.91E-40 152 ACH7_CAEEL reviewed Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1) lev-1 F09E8.7 Caenorhabditis elegans 507 "inorganic cation transmembrane transport [GO:0098662]; neuromuscular synaptic transmission [GO:0007274]; regulation of locomotion [GO:0040012]; regulation of oviposition [GO:0046662]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0040012; GO:0043005; GO:0043025; GO:0045211; GO:0046662; GO:0098662 0 0 0 PF02931;PF02932; Q2KIN5 CHOYP_HMBS.1.1 m.31422 sp HEM3_BOVIN 56.56 343 140 3 6 346 20 355 1.91E-128 383 HEM3_BOVIN reviewed Porphobilinogen deaminase (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) HMBS Bos taurus (Bovine) 361 peptidyl-pyrromethane cofactor linkage [GO:0018160]; protoporphyrinogen IX biosynthetic process [GO:0006782] GO:0004418; GO:0006782; GO:0018160 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. 0 0 PF01379;PF03900; Q2T9K6 CHOYP_FEM1C-Z.1.1 m.16596 sp FEM1C_XENLA 25.475 263 170 8 58 304 47 299 1.91E-18 93.2 FEM1C_XENLA reviewed Protein fem-1 homolog C (FEM1c) (FEM1-gamma) fem1c Xenopus laevis (African clawed frog) 617 protein ubiquitination [GO:0016567] GO:0005737; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q5I0S8 CHOYP_MPET_1013.1.2 m.36696 sp ILEU_XENTR 42.744 379 205 7 1 372 4 377 1.91E-93 287 ILEU_XENTR reviewed Leukocyte elastase inhibitor (Serpin B1) serpinb1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 377 0 GO:0004867; GO:0005615; GO:0005737 0 0 0 PF00079; Q5T197 CHOYP_PHUM_PHUM361090.1.1 m.50669 sp DCST1_HUMAN 30.402 671 418 14 125 783 68 701 1.91E-84 286 DCST1_HUMAN reviewed DC-STAMP domain-containing protein 1 DCST1 Homo sapiens (Human) 706 0 GO:0008270; GO:0016021 0 0 0 PF07782; Q5T9S5 CHOYP_LOC100372626.1.2 m.8346 sp CCD18_HUMAN 28.947 1292 831 19 141 1388 123 1371 1.91E-109 385 CCD18_HUMAN reviewed Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) CCDC18 Homo sapiens (Human) 1454 0 0 0 0 0 0 Q5UQP2 CHOYP_LOC582782.1.4 m.8110 sp YL446_MIMIV 30.928 194 122 3 142 333 55 238 1.91E-20 96.7 YL446_MIMIV reviewed Uncharacterized protein L446 (EC 3.1.1.-) MIMI_L446 Acanthamoeba polyphaga mimivirus (APMV) 332 lipid catabolic process [GO:0016042] GO:0016021; GO:0016042; GO:0016787 0 0 0 PF01734; Q5XHZ6 CHOYP_LOC100083167.1.1 m.46714 sp KLHL7_RAT 29.437 231 155 4 106 332 29 255 1.91E-19 95.1 KLHL7_RAT reviewed Kelch-like protein 7 Klhl7 Rattus norvegicus (Rat) 586 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005654; GO:0005730; GO:0005737; GO:0005886; GO:0016567; GO:0031463; GO:0042787; GO:0042803 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q60787 CHOYP_LCP2.2.14 m.5556 sp LCP2_MOUSE 36.885 122 74 2 171 289 402 523 1.91E-19 91.7 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q642H2 CHOYP_CRBL2.3.7 m.5926 sp CRBL2_DANRE 50 64 30 1 8 71 10 71 1.91E-15 69.3 CRBL2_DANRE reviewed cAMP-responsive element-binding protein-like 2 crebl2 zgc:92620 Danio rerio (Zebrafish) (Brachydanio rerio) 119 "cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0030154; GO:0043565; GO:0045600; GO:0045893; GO:0046326; GO:0046889 0 0 0 PF07716; Q68ER9 CHOYP_AGAP_AGAP006810.1.2 m.12514 sp EAF6_XENTR 52.198 182 62 4 8 174 12 183 1.91E-51 166 EAF6_XENTR reviewed Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) meaf6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 191 "histone H2A acetylation [GO:0043968]; histone H3-K14 acetylation [GO:0044154]; histone H4-K12 acetylation [GO:0043983]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000776; GO:0000777; GO:0005730; GO:0006351; GO:0006355; GO:0035267; GO:0043968; GO:0043981; GO:0043982; GO:0043983; GO:0044154; GO:0070776 0 0 0 PF09340; Q68F72 CHOYP_LOC100374039.1.1 m.29279 sp S15A4_XENLA 36.13 584 311 13 1 537 1 569 1.91E-107 337 S15A4_XENLA reviewed Solute carrier family 15 member 4 (Peptide transporter 4) slc15a4 Xenopus laevis (African clawed frog) 569 oligopeptide transport [GO:0006857]; protein transport [GO:0015031] GO:0006857; GO:0015031; GO:0015293; GO:0016021 0 0 cd06174; PF00854; Q6DIB5 CHOYP_MEGF6.30.59 m.39833 sp MEG10_MOUSE 35.533 788 442 36 32 793 111 858 1.91E-103 348 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6DQX6 CHOYP_BRAFLDRAFT_58035.2.2 m.65814 sp NDUBB_CRIGR 29.63 162 102 6 16 176 1 151 1.91E-13 67.8 NDUBB_CRIGR reviewed "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (Complex I-ESSS) (CI-ESSS) (NADH-ubiquinone oxidoreductase ESSS subunit)" NDUFB11 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 151 oxidation-reduction process [GO:0055114] GO:0005743; GO:0016021; GO:0055114; GO:0070469 0 0 0 PF10183; Q6UW01 CHOYP_LOC100705460.2.3 m.5770 sp CBLN3_HUMAN 32.331 133 81 4 65 189 71 202 1.91E-06 49.7 CBLN3_HUMAN reviewed Cerebellin-3 CBLN3 UNQ755/PRO1486 Homo sapiens (Human) 205 0 GO:0005615; GO:0005783; GO:0005794; GO:0030054; GO:0045202 0 0 0 PF00386; Q7Z449 CHOYP_CP2U1.1.1 m.14182 sp CP2U1_HUMAN 35.671 499 287 8 15 483 49 543 1.91E-99 312 CP2U1_HUMAN reviewed Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Homo sapiens (Human) 544 omega-hydroxylase P450 pathway [GO:0097267] GO:0004497; GO:0005506; GO:0005789; GO:0008395; GO:0016021; GO:0019825; GO:0020037; GO:0031090; GO:0070330; GO:0097267 0 0 0 PF00067; Q8BGN2 CHOYP_CD033.1.1 m.25350 sp CD033_MOUSE 55.435 184 78 2 1 180 1 184 1.91E-66 205 CD033_MOUSE reviewed UPF0462 protein C4orf33 homolog D3Ertd751e Mus musculus (Mouse) 192 0 0 0 0 0 0 Q8BZ20 CHOYP_LOC100370625.1.3 m.4613 sp PAR12_MOUSE 34.524 168 93 5 304 462 75 234 1.91E-18 92.4 PAR12_MOUSE reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) 711 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q8IWZ3 CHOYP_LOC753709.37.44 m.60796 sp ANKH1_HUMAN 31.4 500 284 15 647 1128 200 658 1.91E-42 174 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8R035 CHOYP_AAEL_AAEL010339.1.1 m.63259 sp ICT1_MOUSE 42.604 169 89 2 33 200 37 198 1.91E-37 132 ICT1_MOUSE reviewed "Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Immature colon carcinoma transcript 1 protein homolog)" Ict1 Mrpl58 Mus musculus (Mouse) 206 mitochondrial translational termination [GO:0070126]; rescue of stalled ribosome [GO:0072344] GO:0004045; GO:0005739; GO:0005762; GO:0016150; GO:0043022; GO:0070126; GO:0072344 0 0 0 PF00472; Q91Y25 CHOYP_BRAFLDRAFT_118099.4.6 m.31163 sp FAM21_CRIGR 45.19 447 184 16 4 446 13 402 1.91E-81 277 FAM21_CRIGR reviewed WASH complex subunit FAM21 Fam21 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 1317 "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005769; GO:0005829; GO:0005886; GO:0015031; GO:0031901; GO:0042147; GO:0071203 0 0 0 PF15255; Q91Z53 CHOYP_BRAFLDRAFT_104160.1.1 m.29524 sp GRHPR_MOUSE 57.729 317 130 3 6 319 9 324 1.91E-123 360 GRHPR_MOUSE reviewed Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) Grhpr Glxr Mus musculus (Mouse) 328 dicarboxylic acid metabolic process [GO:0043648]; excretion [GO:0007588]; oxidation-reduction process [GO:0055114]; protein oligomerization [GO:0051259] GO:0005737; GO:0005829; GO:0007588; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0051259; GO:0051287; GO:0055114; GO:0070062; GO:0070402 0 0 0 PF00389;PF02826; Q95SS8 CHOYP_DGRI_GH16859.1.1 m.29409 sp TMM70_DROME 29.545 176 106 3 71 240 56 219 1.91E-19 87 TMM70_DROME reviewed "Transmembrane protein 70 homolog, mitochondrial" CG7506 Drosophila melanogaster (Fruit fly) 236 mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] GO:0032592; GO:0033615 0 0 0 PF06979; Q96RW7 CHOYP_LOC100372865.1.1 m.60626 sp HMCN1_HUMAN 38.83 376 209 8 75 441 4505 4868 1.91E-74 259 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96S16 CHOYP_JMJD6.1.1 m.62575 sp JMJD8_HUMAN 35.484 248 137 11 123 363 98 329 1.91E-28 119 JMJD8_HUMAN reviewed JmjC domain-containing protein 8 (Jumonji domain-containing protein 8) JMJD8 C16orf20 PP14397 Homo sapiens (Human) 334 0 GO:0070062 0 0 0 0 Q9BXU1 CHOYP_STK31.1.1 m.16297 sp STK31_HUMAN 23.581 1022 672 28 103 1082 7 961 1.91E-48 192 STK31_HUMAN reviewed Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine-protein kinase NYD-SPK) (Sugen kinase 396) (SgK396) STK31 SGK396 Homo sapiens (Human) 1019 0 GO:0001669; GO:0004674; GO:0005524 0 0 0 PF00069;PF00567; Q9GNE2 CHOYP_LOC100370957.1.1 m.22437 sp RL23_AEDAE 89.247 93 10 0 10 102 2 94 1.91E-53 166 RL23_AEDAE reviewed 60S ribosomal protein L23 (AeRpL17A) (L17A) RpL23-A RpL17A AAEL013097; RpL23-B AAEL013583; RpL23-C AAEL015006 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 140 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00238; Q9H1Q7 CHOYP_BRAFLDRAFT_126881.2.2 m.15702 sp PED1A_HUMAN 48.649 259 131 1 8 264 21 279 1.91E-93 296 PED1A_HUMAN reviewed PC-esterase domain-containing protein 1A (Protein FAM113A) (Sarcoma antigen NY-SAR-23) PCED1A C20orf81 FAM113A Homo sapiens (Human) 454 0 0 0 0 0 PF13839; Q9NTG1 CHOYP_BRAFLDRAFT_92073.3.3 m.62369 sp PKDRE_HUMAN 24.792 1081 691 29 1864 2869 1183 2216 1.91E-71 271 PKDRE_HUMAN reviewed Polycystic kidney disease and receptor for egg jelly-related protein (PKD and REJ homolog) PKDREJ Homo sapiens (Human) 2253 acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0007340; GO:0016020; GO:0016021; GO:0050982 0 0 0 PF08016;PF01477;PF02010; Q9PWF7 CHOYP_CATA.1.3 m.11120 sp CATA_RUGRU 66.794 262 86 1 44 305 238 498 1.91E-124 369 CATA_RUGRU reviewed Catalase (EC 1.11.1.6) cat Rugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa) 528 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004096; GO:0005777; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF00199;PF06628; A6BM72 CHOYP_MEG10.80.91 m.60740 sp MEG11_HUMAN 35.849 212 122 9 22 233 456 653 1.92E-24 107 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; A6QPN6 CHOYP_BRAFLDRAFT_126371.1.3 m.41721 sp GILT_BOVIN 40.67 209 110 7 54 258 34 232 1.92E-43 150 GILT_BOVIN reviewed Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (IFI30 protein) IFI30 Bos taurus (Bovine) 244 antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590] GO:0005576; GO:0005764; GO:0016667; GO:0042590 0 0 0 PF03227; A7LCJ2 CHOYP_LOC100893270.3.3 m.44116 sp PA2_URTCR 35.772 123 73 4 17 136 31 150 1.92E-17 77.4 PA2_URTCR reviewed Phospholipase A2 A2-actitoxin-Ucs2a (A2-AITX-Ucs2a) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (UcPLA2) 0 Urticina crassicornis (Mottled anemone) (Tealia crassicornis) 155 lipid catabolic process [GO:0016042] GO:0004623; GO:0005509; GO:0005576; GO:0016042; GO:0042151 0 0 0 PF00068; B3EWZ5 CHOYP_LOC100376516.1.1 m.59232 sp MLRP1_ACRMI 28.571 161 104 6 113 266 256 412 1.92E-12 70.9 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D2GXS7 CHOYP_BRAFLDRAFT_109857.2.15 m.8079 sp TRIM2_AILME 32.075 106 68 3 25 127 627 731 1.92E-07 52 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O05389 CHOYP_LOC100905188.1.1 m.2446 sp YRBE_BACSU 30.06 336 224 6 40 374 8 333 1.92E-46 164 YRBE_BACSU reviewed Uncharacterized oxidoreductase YrbE (EC 1.-.-.-) yrbE BSU27770 Bacillus subtilis (strain 168) 341 oxidation-reduction process [GO:0055114] GO:0016491; GO:0055114 0 0 0 PF01408;PF02894; O43301 CHOYP_BRAFLDRAFT_208197.4.21 m.21323 sp HS12A_HUMAN 34.628 309 150 8 10 273 50 351 1.92E-47 171 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O54890 CHOYP_ITB1.4.4 m.48091 sp ITB3_MOUSE 34.766 768 445 24 33 768 38 781 1.92E-148 456 ITB3_MOUSE reviewed Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) Itgb3 Mus musculus (Mouse) 787 activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cell adhesion mediated by integrin [GO:0033627]; cell growth [GO:0016049]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell projection morphogenesis [GO:0048858]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045715]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of extracellular matrix organization [GO:1903053]; regulation of protein tyrosine kinase activity [GO:0061097]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; viral entry into host cell [GO:0046718] GO:0001938; GO:0001954; GO:0001968; GO:0002020; GO:0003756; GO:0004872; GO:0005178; GO:0005634; GO:0005886; GO:0005925; GO:0007044; GO:0007160; GO:0007229; GO:0008305; GO:0009897; GO:0009986; GO:0010595; GO:0010628; GO:0010745; GO:0010763; GO:0010888; GO:0014909; GO:0016049; GO:0016324; GO:0016477; GO:0019899; GO:0030168; GO:0030334; GO:0030335; GO:0031258; GO:0031527; GO:0031528; GO:0031589; GO:0032147; GO:0032369; GO:0032587; GO:0032956; GO:0033627; GO:0033690; GO:0034113; GO:0034446; GO:0034679; GO:0034683; GO:0035867; GO:0036120; GO:0038027; GO:0042470; GO:0042802; GO:0043184; GO:0043235; GO:0045672; GO:0045715; GO:0045780; GO:0046718; GO:0048008; GO:0048146; GO:0048858; GO:0050731; GO:0050748; GO:0050839; GO:0050840; GO:0050919; GO:0060055; GO:0061097; GO:0070062; GO:0070527; GO:0071133; GO:1900026; GO:1903053; GO:2000406 0 0 0 PF07974;PF08725;PF07965;PF00362; P08472 CHOYP_LOC100377195.1.2 m.28624 sp M130_STRPU 28.108 370 208 12 220 563 400 737 1.92E-28 124 M130_STRPU reviewed Mesenchyme-specific cell surface glycoprotein (MSP130) 0 Strongylocentrotus purpuratus (Purple sea urchin) 779 0 GO:0005886; GO:0031225 0 0 0 0 P10180 CHOYP_MUC1.1.5 m.5913 sp CUT_DROME 73 100 23 1 76 171 1292 1391 1.92E-42 154 CUT_DROME reviewed Homeobox protein cut ct CG11387 Drosophila melanogaster (Fruit fly) 2175 "antennal development [GO:0007469]; antennal joint development [GO:0048098]; central nervous system development [GO:0007417]; dendrite guidance [GO:0070983]; dendrite morphogenesis [GO:0048813]; female gonad development [GO:0008585]; formation of a compartment boundary [GO:0060288]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; Malpighian tubule bud morphogenesis [GO:0061332]; Malpighian tubule morphogenesis [GO:0007443]; mitotic cell cycle [GO:0000278]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; regulation of transcription, DNA-templated [GO:0006355]; sensory perception of sound [GO:0007605]; spiracle morphogenesis, open tracheal system [GO:0035277]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000278; GO:0000976; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007417; GO:0007422; GO:0007424; GO:0007443; GO:0007469; GO:0007605; GO:0008585; GO:0008587; GO:0030707; GO:0030713; GO:0035277; GO:0045746; GO:0048098; GO:0048477; GO:0048813; GO:0060288; GO:0061332; GO:0070983 0 0 0 PF02376;PF00046; P18288 CHOYP_RABGAP1.1.1 m.50534 sp TBAT_ONCMY 98.193 166 3 0 1 166 1 166 1.92E-118 345 TBAT_ONCMY reviewed "Tubulin alpha chain, testis-specific [Cleaved into: Detyrosinated tubulin alpha chain, testis-specific]" 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P18503 CHOYP_BRAFLDRAFT_76550.12.21 m.51114 sp CAS4_EPHMU 33.333 138 67 6 52 185 209 325 1.92E-06 51.2 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P18503 CHOYP_BRAFLDRAFT_76550.19.21 m.65769 sp CAS4_EPHMU 32.117 137 77 3 66 201 192 313 1.92E-08 57.8 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P49024 CHOYP_CPIPJ_CPIJ003871.1.1 m.147 sp PAXI_CHICK 53.145 461 151 9 118 550 135 558 1.92E-162 476 PAXI_CHICK reviewed Paxillin PXN Gallus gallus (Chicken) 559 cell-matrix adhesion [GO:0007160]; response to muscle stretch [GO:0035994] GO:0001725; GO:0005623; GO:0005737; GO:0005886; GO:0005925; GO:0007160; GO:0008270; GO:0017166; GO:0035994 0 0 0 PF00412; P80646 CHOYP_CTRA.1.2 m.26705 sp CTRB_GADMO 39.227 181 104 5 317 494 16 193 1.92E-32 127 CTRB_GADMO reviewed Chymotrypsin B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B] 0 Gadus morhua (Atlantic cod) 245 digestion [GO:0007586] GO:0004252; GO:0005615; GO:0007586 0 0 cd00190; PF00089; Q02543 CHOYP_RL18A.8.8 m.66645 sp RL18A_HUMAN 70.253 158 47 0 11 168 2 159 1.92E-80 239 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q05695 CHOYP_CPIPJ_CPIJ008112.1.1 m.51524 sp L1CAM_RAT 21.901 484 321 19 39 501 48 495 1.92E-20 99.4 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q0P5M9 CHOYP_LOC592950.1.1 m.41605 sp MFS10_BOVIN 44.792 288 143 4 1 283 176 452 1.92E-77 245 MFS10_BOVIN reviewed Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein) MFSD10 TETRAN Bos taurus (Bovine) 456 apoptotic process [GO:0006915]; sodium-independent organic anion transport [GO:0043252]; tetracycline transport [GO:0015904]; transmembrane transport [GO:0055085] GO:0006915; GO:0008493; GO:0008514; GO:0015904; GO:0016021; GO:0030659; GO:0031526; GO:0043252; GO:0055085 0 0 cd06174; PF07690; Q1RHT6 CHOYP_TVAG_309070.1.1 m.27162 sp Y997_RICBR 22.581 279 162 9 254 532 72 296 1.92E-06 55.1 Y997_RICBR reviewed Putative ankyrin repeat protein RBE_0997 RBE_0997 Rickettsia bellii (strain RML369-C) 614 glutamine metabolic process [GO:0006541] GO:0006541; GO:0016787 0 0 0 PF12796;PF07722; Q27991 CHOYP_LOC585963.1.2 m.36775 sp MYH10_BOVIN 23.752 1002 574 40 8484 9424 849 1721 1.92E-35 155 MYH10_BOVIN reviewed "Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB)" MYH10 Bos taurus (Bovine) 1976 "actin filament-based movement [GO:0030048]; adult heart development [GO:0007512]; aorta development [GO:0035904]; axon guidance [GO:0007411]; cardiac myofibril assembly [GO:0055003]; cardiac septum development [GO:0003279]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; cerebellar Purkinje cell layer development [GO:0021680]; coronary vasculature development [GO:0060976]; exocytosis [GO:0006887]; fourth ventricle development [GO:0021592]; in utero embryonic development [GO:0001701]; lateral ventricle development [GO:0021670]; mitotic cytokinesis [GO:0000281]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear migration [GO:0007097]; plasma membrane repair [GO:0001778]; regulation of cell shape [GO:0008360]; retina development in camera-type eye [GO:0060041]; substrate-dependent cell migration, cell extension [GO:0006930]; third ventricle development [GO:0021678]; ventricular cardiac muscle cell development [GO:0055015]" GO:0000146; GO:0000281; GO:0001701; GO:0001725; GO:0001764; GO:0001778; GO:0003279; GO:0005524; GO:0005634; GO:0005739; GO:0005819; GO:0005886; GO:0005903; GO:0005938; GO:0006887; GO:0006930; GO:0007097; GO:0007155; GO:0007411; GO:0007512; GO:0008283; GO:0008360; GO:0016460; GO:0021592; GO:0021670; GO:0021678; GO:0021680; GO:0030027; GO:0030048; GO:0030424; GO:0030426; GO:0030496; GO:0030898; GO:0031594; GO:0032154; GO:0035904; GO:0043025; GO:0043197; GO:0043531; GO:0050885; GO:0055003; GO:0055015; GO:0060041; GO:0060976; GO:0070062; GO:0097513 0 0 0 PF00612;PF00063;PF02736;PF01576; Q27J81 CHOYP_INF2.5.5 m.50304 sp INF2_HUMAN 38.889 360 204 4 2 357 5 352 1.92E-74 268 INF2_HUMAN reviewed Inverted formin-2 (HBEBP2-binding protein C) INF2 C14orf151 C14orf173 Homo sapiens (Human) 1249 actin cytoskeleton organization [GO:0030036]; regulation of mitochondrial fission [GO:0090140] GO:0030036; GO:0048471; GO:0090140 0 0 0 PF06367;PF06371;PF02181;PF02205; Q3B7T1 CHOYP_EDRF1.1.2 m.23166 sp EDRF1_HUMAN 55.769 104 45 1 14 116 991 1094 1.92E-29 114 EDRF1_HUMAN reviewed Erythroid differentiation-related factor 1 EDRF1 C10orf137 Homo sapiens (Human) 1238 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 0 Q3U145 CHOYP_NEMVEDRAFT_V1G245185.1.1 m.6700 sp TMM64_MOUSE 43.421 228 125 3 88 313 116 341 1.92E-58 196 TMM64_MOUSE reviewed Transmembrane protein 64 Tmem64 Mus musculus (Mouse) 381 canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of bone resorption [GO:0045780]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoclast differentiation [GO:0045672]; regulation of ATPase activity [GO:0043462]; regulation of cytosolic calcium ion concentration [GO:0051480] GO:0005783; GO:0016021; GO:0043462; GO:0044339; GO:0045600; GO:0045668; GO:0045672; GO:0045780; GO:0051480; GO:0090090 0 0 0 PF09335; Q4ZJM9 CHOYP_LOC100705460.3.3 m.57888 sp C1QL4_MOUSE 30.909 110 69 3 51 158 109 213 1.92E-09 58.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q505F5 CHOYP_LOC100370672.1.1 m.54509 sp LRC47_MOUSE 40.809 544 271 14 46 544 44 581 1.92E-117 362 LRC47_MOUSE reviewed Leucine-rich repeat-containing protein 47 Lrrc47 Kiaa1185 Mus musculus (Mouse) 581 0 GO:0044822 0 0 0 PF03483;PF12799;PF13855; Q60787 CHOYP_LCP2.13.14 m.55980 sp LCP2_MOUSE 30.568 229 133 6 432 644 305 523 1.92E-19 95.9 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q64319 CHOYP_SLC3A1.1.1 m.14892 sp SLC31_RAT 33.455 550 315 17 85 601 117 648 1.92E-86 286 SLC31_RAT reviewed "Neutral and basic amino acid transport protein rBAT (D2) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NAA-TR)" Slc3a1 Nbat Rattus norvegicus (Rat) 683 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0046982; GO:0070062 0 0 0 PF00128; Q6R5N8 CHOYP_LOC100559714.1.1 m.45488 sp TLR13_MOUSE 25.041 615 386 20 132 701 393 977 1.92E-36 150 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q6V0I7 CHOYP_LOC100376421.3.4 m.45462 sp FAT4_HUMAN 32.075 106 46 3 257 336 3870 3975 1.92E-09 65.1 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q8N6Q8 CHOYP_METTL25.1.1 m.8586 sp MET25_HUMAN 40.708 226 123 4 176 397 373 591 1.92E-46 171 MET25_HUMAN reviewed Methyltransferase-like protein 25 (EC 2.1.1.-) METTL25 C12orf26 Homo sapiens (Human) 603 0 GO:0008168 0 0 0 PF13679; Q96MM6 CHOYP_BRAFLDRAFT_242762.1.8 m.4833 sp HS12B_HUMAN 28.237 641 366 20 38 599 58 683 1.92E-66 232 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96RW7 CHOYP_HMCN2.6.12 m.33452 sp HMCN1_HUMAN 26.213 1381 852 61 301 1634 468 1728 1.92E-75 284 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99MX7 CHOYP_NEMVEDRAFT_V1G246927.1.1 m.51217 sp CECR6_MOUSE 25.246 305 161 9 23 267 202 499 1.92E-09 62 CECR6_MOUSE reviewed Cat eye syndrome critical region protein 6 homolog Cecr6 Mus musculus (Mouse) 572 0 0 0 0 0 PF14997; Q9CR11 CHOYP_LOC100374387.1.1 m.46589 sp YETS4_MOUSE 70.455 220 65 0 1 220 5 224 1.92E-112 324 YETS4_MOUSE reviewed YEATS domain-containing protein 4 Yeats4 Mus musculus (Mouse) 227 "histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; regulation of growth [GO:0040008]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005654; GO:0006351; GO:0006355; GO:0008022; GO:0035267; GO:0040008; GO:0043967; GO:0043968 0 0 0 PF03366; Q9ESN6 CHOYP_LOC100378898.9.10 m.60193 sp TRIM2_MOUSE 29.224 219 136 9 349 559 536 743 1.92E-13 77 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GZV8 CHOYP_LOC100368392.1.1 m.22851 sp PRD14_HUMAN 27.723 202 139 6 101 296 361 561 1.92E-13 74.3 PRD14_HUMAN reviewed PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14) PRDM14 Homo sapiens (Human) 571 "cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; germ cell development [GO:0007281]; germ-line stem cell population maintenance [GO:0030718]; histone H3-R26 methylation [GO:0034972]; homeostasis of number of cells within a tissue [GO:0048873]; inactivation of paternal X chromosome [GO:0060817]; inner cell mass cell fate commitment [GO:0001827]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of DNA methylation [GO:0044030]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000902; GO:0001708; GO:0001827; GO:0003723; GO:0005654; GO:0006351; GO:0007281; GO:0007566; GO:0008168; GO:0009566; GO:0030718; GO:0031490; GO:0034972; GO:0035019; GO:0040037; GO:0044030; GO:0046872; GO:0048873; GO:0060817 0 0 0 PF00096; Q9NWU1 CHOYP_OXSM.1.1 m.30217 sp OXSM_HUMAN 55.37 419 175 5 11 421 42 456 1.92E-156 452 OXSM_HUMAN reviewed "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC 2.3.1.41) (Beta-ketoacyl-ACP synthase)" OXSM Homo sapiens (Human) 459 acyl-CoA metabolic process [GO:0006637]; medium-chain fatty acid biosynthetic process [GO:0051792]; short-chain fatty acid biosynthetic process [GO:0051790] GO:0004315; GO:0005737; GO:0005739; GO:0006637; GO:0051790; GO:0051792 PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 PF00109;PF02801; Q9NXU5 CHOYP_ARL15.1.1 m.12813 sp ARL15_HUMAN 43.182 176 100 0 17 192 15 190 1.92E-54 175 ARL15_HUMAN reviewed ADP-ribosylation factor-like protein 15 (ADP-ribosylation factor-related protein 2) (ARF-related protein 2) ARL15 ARFRP2 Homo sapiens (Human) 204 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0070062 0 0 0 PF00025; Q9P1Z9 CHOYP_LOC100369255.1.3 m.17623 sp CC180_HUMAN 32.998 597 392 3 1 596 184 773 1.92E-100 359 CC180_HUMAN reviewed Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) 1646 0 GO:0016021; GO:0070062 0 0 0 PF14643;PF14644; Q9P215 CHOYP_LOC100366536.2.3 m.18965 sp POGK_HUMAN 35.075 134 73 4 298 424 197 323 1.92E-14 79.3 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9R1R2 CHOYP_LOC592222.2.2 m.46444 sp TRIM3_MOUSE 30.218 321 195 10 103 405 420 729 1.92E-29 124 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9VTK2 CHOYP_DWIL_GK11931.1.1 m.14415 sp POMT1_DROME 44.318 176 98 0 59 234 156 331 1.92E-44 162 POMT1_DROME reviewed Protein O-mannosyltransferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) (dPOMT1) (Protein rotated abdomen) rt POMT1 CG6097 Drosophila melanogaster (Fruit fly) 886 "cell wall mannoprotein biosynthetic process [GO:0000032]; chain elongation of O-linked mannose residue [GO:0044845]; lipid glycosylation [GO:0030259]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; protein O-linked mannosylation [GO:0035269]; regulation of endoplasmic reticulum unfolded protein response [GO:1900101]; regulation of synaptic activity [GO:0060025]; sarcomere organization [GO:0045214]; somatic muscle development [GO:0007525]; specification of segmental identity, abdomen [GO:0007385]" GO:0000032; GO:0004169; GO:0005783; GO:0007385; GO:0007517; GO:0007525; GO:0016021; GO:0016203; GO:0030259; GO:0031502; GO:0035269; GO:0044845; GO:0045214; GO:0060025; GO:1900101 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02815;PF02366;PF16192; Q9W445 CHOYP_LOC100865976.1.1 m.15403 sp MCTS1_DROME 62.637 182 68 0 26 207 1 182 1.92E-85 253 MCTS1_DROME reviewed Malignant T-cell-amplified sequence 1 homolog (Multiple copies in T-cell lymphoma 1 homolog) (MCT-1) MCTS1 CG5941 Drosophila melanogaster (Fruit fly) 182 positive regulation of translational initiation [GO:0045948]; translation reinitiation [GO:0002188] GO:0002188; GO:0003723; GO:0005737; GO:0045948 0 0 0 PF01472; Q9WVR8 CHOYP_LOC589807.1.1 m.59071 sp MEN1_RAT 54.803 458 181 6 8 441 2 457 1.92E-161 482 MEN1_RAT reviewed Menin Men1 Rattus norvegicus (Rat) 610 "brain development [GO:0007420]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to glucose stimulus [GO:0071333]; cellular response to peptide hormone stimulus [GO:0071375]; decidualization [GO:0046697]; histone lysine methylation [GO:0034968]; MAPK cascade [GO:0000165]; mitotic cell cycle [GO:0000278]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of JNK cascade [GO:0046329]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of telomerase activity [GO:0051974]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoblast development [GO:0002076]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of type B pancreatic cell proliferation [GO:0061469]; response to gamma radiation [GO:0010332]; response to transforming growth factor beta [GO:0071559]; response to UV [GO:0009411]; transcription, DNA-templated [GO:0006351]; type B pancreatic cell differentiation [GO:0003309]" GO:0000122; GO:0000165; GO:0000278; GO:0000400; GO:0000403; GO:0000785; GO:0002076; GO:0003309; GO:0003682; GO:0003690; GO:0005634; GO:0005829; GO:0006351; GO:0006974; GO:0007420; GO:0009411; GO:0010332; GO:0010812; GO:0016363; GO:0018024; GO:0030511; GO:0032092; GO:0032154; GO:0032925; GO:0034968; GO:0035097; GO:0043433; GO:0044212; GO:0045668; GO:0045736; GO:0045944; GO:0046329; GO:0046697; GO:0050680; GO:0051974; GO:0061469; GO:0071333; GO:0071375; GO:0071559; GO:1902807 0 0 cd14456; PF05053; Q9Y236 CHOYP_OSGI2.1.1 m.11055 sp OSGI2_HUMAN 45.851 482 242 9 12 482 19 492 1.92E-135 403 OSGI2_HUMAN reviewed Oxidative stress-induced growth inhibitor 2 (hT41) OSGIN2 C8orf1 Homo sapiens (Human) 505 meiotic cell cycle [GO:0051321] GO:0016491; GO:0051321 0 0 0 0 Q9Z1J2 CHOYP_NEK4.5.8 m.39106 sp NEK4_MOUSE 37.457 291 168 5 10 294 10 292 1.92E-59 207 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; A4IF63 CHOYP_LOC100313668.5.6 m.53592 sp TRIM2_BOVIN 31.496 127 83 2 184 308 620 744 1.93E-10 65.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8MU46 CHOYP_CG34417.1.2 m.18203 sp SMTL1_HUMAN 55.705 149 60 2 1754 1900 302 446 1.93E-48 184 SMTL1_HUMAN reviewed Smoothelin-like protein 1 SMTNL1 Homo sapiens (Human) 457 negative regulation of vasodilation [GO:0045908]; positive regulation of vasoconstriction [GO:0045907] GO:0005634; GO:0005737; GO:0031430; GO:0031674; GO:0043292; GO:0045907; GO:0045908 0 0 0 PF00307; B1AK53 CHOYP_ESPN.2.2 m.62532 sp ESPN_HUMAN 32.022 178 105 5 267 437 142 310 1.93E-15 82.4 ESPN_HUMAN reviewed Espin (Autosomal recessive deafness type 36 protein) (Ectoplasmic specialization protein) ESPN DFNB36 LP2654 Homo sapiens (Human) 854 locomotory behavior [GO:0007626]; negative regulation of cytoskeleton organization [GO:0051494]; parallel actin filament bundle assembly [GO:0030046]; positive regulation of filopodium assembly [GO:0051491]; sensory perception of sound [GO:0007605] GO:0005737; GO:0005902; GO:0005903; GO:0007605; GO:0007626; GO:0017124; GO:0030046; GO:0031941; GO:0032426; GO:0051015; GO:0051491; GO:0051494 0 0 0 PF12796;PF02205; O05972 CHOYP_LOC586122.4.4 m.63775 sp Y028_RICPR 31.683 101 66 3 161 259 47 146 1.93E-06 52.4 Y028_RICPR reviewed Uncharacterized protein RP028 RP028 Rickettsia prowazekii (strain Madrid E) 250 0 0 0 0 0 PF13847; O15034 CHOYP_RIMB2.3.5 m.17363 sp RIMB2_HUMAN 37.634 465 237 10 978 1434 167 586 1.93E-75 277 RIMB2_HUMAN reviewed RIMS-binding protein 2 (RIM-BP2) RIMBP2 KIAA0318 RBP2 Homo sapiens (Human) 1052 negative regulation of phosphatase activity [GO:0010923] GO:0005886; GO:0010923; GO:0030054; GO:0045202 0 0 0 PF07653;PF14604; O43822 CHOYP_LOC576797.1.1 m.8986 sp CU002_HUMAN 39.286 280 132 5 19 296 2 245 1.93E-51 172 CU002_HUMAN reviewed Protein C21orf2 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) C21orf2 LRRC76 Homo sapiens (Human) 256 cilium morphogenesis [GO:0060271]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]; smoothened signaling pathway [GO:0007224] GO:0005737; GO:0005739; GO:0005886; GO:0007010; GO:0007224; GO:0008360; GO:0032391; GO:0036064; GO:0060271 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_87295.8.9 m.64649 sp TRIM3_RAT 25.984 127 87 3 36 160 622 743 1.93E-06 51.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC100369754.1.10 m.1073 sp TRIM3_RAT 21.97 264 184 7 330 578 488 744 1.93E-11 70.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O93384 CHOYP_RSAD2.1.1 m.55448 sp RSAD2_ONCMY 62.463 341 121 3 14 349 10 348 1.93E-161 458 RSAD2_ONCMY reviewed "Radical S-adenosyl methionine domain-containing protein 2 (Viperin) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)" rsad2 vig1 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 348 defense response to virus [GO:0051607]; innate immune response [GO:0045087] GO:0003824; GO:0005789; GO:0005811; GO:0045087; GO:0046872; GO:0051539; GO:0051607 0 0 0 PF04055; O95817 CHOYP_LOC100369920.1.1 m.4219 sp BAG3_HUMAN 50 42 21 0 7 48 21 62 1.93E-06 54.3 BAG3_HUMAN reviewed BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) 575 brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cellular response to heat [GO:1900034]; spinal cord development [GO:0021510] GO:0000774; GO:0005737; GO:0005829; GO:0005886; GO:0005913; GO:0006457; GO:0007420; GO:0008625; GO:0010664; GO:0021510; GO:0030018; GO:0043005; GO:0043066; GO:0050821; GO:0071260; GO:0097192; GO:0098641; GO:1900034 0 0 0 PF02179;PF00397; P10077 CHOYP_LOC101020089.1.1 m.9396 sp ZFP27_MOUSE 31.164 584 352 14 256 818 178 732 1.93E-68 246 ZFP27_MOUSE reviewed Zinc finger protein 27 (Zfp-27) (Protein mKR4) Zfp27 Mkr4 Zfp-27 Mus musculus (Mouse) 819 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; P10394 CHOYP_contig_014797 m.17049 sp POL4_DROME 23.823 361 237 11 215 566 49 380 1.93E-12 73.9 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P20825 CHOYP_contig_009672 m.11234 sp POL2_DROME 24.578 415 269 9 8 387 506 911 1.93E-27 118 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P24733 CHOYP_MYS.1.7 m.441 sp MYS_ARGIR 54.839 93 42 0 4 96 1224 1316 1.93E-23 97.8 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P48763 CHOYP_AAEL_AAEL001503.1.1 m.10649 sp SL9A2_RAT 46.691 544 272 6 10 540 32 570 1.93E-160 496 SL9A2_RAT reviewed Sodium/hydrogen exchanger 2 (H7) (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) Slc9a2 Nhe2 Rattus norvegicus (Rat) 813 protein localization [GO:0008104]; regulation of pH [GO:0006885] GO:0006885; GO:0008104; GO:0015385; GO:0016021; GO:0016324 0 0 0 PF00999;PF16644; P49395 CHOYP_RS3A.7.15 m.20182 sp RS3A_APLCA 67.972 281 48 2 31 310 21 260 1.93E-132 379 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P49454 CHOYP_TVAG_355490.2.22 m.9582 sp CENPF_HUMAN 51.938 129 62 0 15 143 1 129 1.93E-27 127 CENPF_HUMAN reviewed Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin) CENPF Homo sapiens (Human) 3210 "cell differentiation [GO:0030154]; cell division [GO:0051301]; cell proliferation [GO:0008283]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; kidney development [GO:0001822]; kinetochore assembly [GO:0051382]; metaphase plate congression [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of transcription, DNA-templated [GO:0045892]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to drug [GO:0042493]; sister chromatid cohesion [GO:0007062]; ventricular system development [GO:0021591]" GO:0000278; GO:0000775; GO:0000776; GO:0000922; GO:0000940; GO:0001822; GO:0003682; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005930; GO:0007059; GO:0007062; GO:0007067; GO:0007094; GO:0007517; GO:0008022; GO:0008134; GO:0008283; GO:0010389; GO:0015031; GO:0016202; GO:0016363; GO:0021591; GO:0030154; GO:0030496; GO:0036064; GO:0042493; GO:0042803; GO:0045120; GO:0045502; GO:0045892; GO:0048471; GO:0051301; GO:0051310; GO:0051382; GO:0051726; GO:0071897; GO:0097539 0 0 0 PF10490;PF10473;PF10481; P55866 CHOYP_CASP10.6.7 m.58539 sp CASP3_XENLA 25.275 273 176 8 295 547 16 280 1.93E-11 68.6 CASP3_XENLA reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (xCPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] casp3 Xenopus laevis (African clawed frog) 282 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 P62912 CHOYP_LOC100202227.1.1 m.22404 sp RL32_RAT 75.385 130 32 0 4 133 6 135 1.93E-70 210 RL32_RAT reviewed 60S ribosomal protein L32 Rpl32 Rattus norvegicus (Rat) 135 cellular response to dexamethasone stimulus [GO:0071549]; liver regeneration [GO:0097421]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022625; GO:0044822; GO:0071549; GO:0097421 0 0 cd00513; PF01655; P82915 CHOYP_RT16.1.1 m.16545 sp RT16_BOVIN 47.222 108 57 0 1 108 9 116 1.93E-32 116 RT16_BOVIN reviewed "28S ribosomal protein S16, mitochondrial (MRP-S16) (S16mt)" MRPS16 RPMS16 Bos taurus (Bovine) 135 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005763; GO:0032543; GO:0070124; GO:0070125 0 0 0 PF00886; Q0P5A2 CHOYP_COQ5.1.1 m.29788 sp COQ5_BOVIN 59.766 256 93 3 1 256 82 327 1.93E-104 309 COQ5_BOVIN reviewed "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5)" COQ5 Bos taurus (Bovine) 330 methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744] GO:0005739; GO:0006744; GO:0008425; GO:0008757; GO:0031314; GO:0032259; GO:0102005 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03191}. 0 0 PF01209; Q12816 CHOYP_CFU_3729.2.2 m.17801 sp TROP_HUMAN 35.149 202 109 6 401 588 941 1134 1.93E-06 55.5 TROP_HUMAN reviewed Trophinin (MAGE-D3 antigen) TRO KIAA1114 MAGED3 Homo sapiens (Human) 1431 embryo implantation [GO:0007566]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell growth [GO:0030308] GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0007156; GO:0007566; GO:0030308 0 0 0 PF01454; Q13310 CHOYP_LOC101236942.1.1 m.54823 sp PABP4_HUMAN 59.77 87 33 1 1 87 326 410 1.93E-28 110 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q3U3C9 CHOYP_M3K7.2.4 m.17369 sp GSE1_MOUSE 37.464 347 172 16 732 1055 3 327 1.93E-24 115 GSE1_MOUSE reviewed Genetic suppressor element 1 Gse1 Kiaa0182 Mus musculus (Mouse) 1213 0 0 0 0 0 PF12540; Q4G5Y1 CHOYP_LOC101160276.1.1 m.38550 sp KLDC2_MOUSE 37.008 381 220 8 26 395 26 397 1.93E-78 251 KLDC2_MOUSE reviewed Kelch domain-containing protein 2 (Endothelial differentiation inhibitory protein TNG) Klhdc2 Mus musculus (Mouse) 406 0 GO:0005634; GO:0031965 0 0 0 0 Q502M6 CHOYP_LOC578974.6.11 m.32931 sp ANR29_DANRE 42.963 135 77 0 1 135 66 200 1.93E-27 105 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5F2F2 CHOYP_LOC100497109.1.1 m.14535 sp ABH15_MOUSE 37.861 346 200 7 102 434 66 409 1.93E-65 220 ABH15_MOUSE reviewed Protein ABHD15 (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) Abhd15 Mus musculus (Mouse) 459 0 GO:0005576; GO:0016020; GO:0016787 0 0 0 0 Q5F384 CHOYP_BRAFLDRAFT_215782.1.1 m.60932 sp YIPF3_CHICK 50.593 253 122 1 62 314 78 327 1.93E-86 267 YIPF3_CHICK reviewed Protein YIPF3 (YIP1 family member 3) YIPF3 RCJMB04_29b14 Gallus gallus (Chicken) 336 cell differentiation [GO:0030154] GO:0005794; GO:0005886; GO:0016021; GO:0030154 0 0 0 0 Q5FVR4 CHOYP_ERI1.1.1 m.8148 sp ERI1_RAT 53.358 268 120 4 36 299 53 319 1.93E-97 296 ERI1_RAT reviewed 3'-5' exoribonuclease 1 (EC 3.1.-.-) (Histone mRNA 3'-exonuclease 1) Eri1 Thex1 Rattus norvegicus (Rat) 345 "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; gene silencing by RNA [GO:0031047]; rRNA 3'-end processing [GO:0031125]" GO:0000467; GO:0005634; GO:0005730; GO:0005737; GO:0008408; GO:0019843; GO:0031047; GO:0031125; GO:0043022; GO:0046872; GO:0071204; GO:0071207 0 0 0 PF00929;PF02037; Q5R8H5 CHOYP_T2EA.1.1 m.39313 sp T2EA_PONAB 42.727 440 215 8 1 406 1 437 1.93E-116 350 T2EA_PONAB reviewed General transcription factor IIE subunit 1 (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha) GTF2E1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 439 "regulation of transcription, DNA-templated [GO:0006355]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0005634; GO:0005737; GO:0006355; GO:0006367; GO:0043565; GO:0046872 0 0 0 PF08271;PF11521;PF02002; Q5R957 CHOYP_LOAG_05718.1.1 m.48540 sp CLIC4_PONAB 35.95 242 117 7 1 212 7 240 1.93E-40 142 CLIC4_PONAB reviewed Chloride intracellular channel protein 4 CLIC4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 253 apoptotic process [GO:0006915] GO:0005244; GO:0005254; GO:0005634; GO:0005886; GO:0006915; GO:0030659; GO:0034707 0 0 0 0 Q5UR67 CHOYP_LOC100638431.1.10 m.3025 sp RIBX_MIMIV 42.073 164 84 3 301 453 2 165 1.93E-28 114 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q60803 CHOYP_TRAF3.4.4 m.63864 sp TRAF3_MOUSE 40.402 547 291 11 20 553 42 566 1.93E-142 426 TRAF3_MOUSE reviewed TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) 567 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; toll-like receptor signaling pathway [GO:0002224]; Toll signaling pathway [GO:0008063]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005768; GO:0006915; GO:0008063; GO:0008270; GO:0009898; GO:0016874; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032088; GO:0032648; GO:0033209; GO:0035631; GO:0042981; GO:0045087; GO:0050688 0 0 0 PF02176; Q60847 CHOYP_BRAFLDRAFT_90332.1.4 m.2812 sp COCA1_MOUSE 35.87 184 113 3 82 263 140 320 1.93E-29 128 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q66S03 CHOYP_LECG.3.4 m.29627 sp LECG_THANI 31.579 152 96 5 9 158 12 157 1.93E-18 80.5 LECG_THANI reviewed Galactose-specific lectin nattectin (CTL) 0 Thalassophryne nattereri (Niquim) 159 inflammatory response [GO:0006954] GO:0005576; GO:0006954; GO:0030246; GO:0046872 0 0 0 PF00059; Q6AI14 CHOYP_LOC100898717.3.3 m.37207 sp SL9A4_HUMAN 41.152 243 140 2 5 247 14 253 1.93E-51 183 SL9A4_HUMAN reviewed Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4) SLC9A4 NHE4 Homo sapiens (Human) 798 epithelial cell development [GO:0002064]; gastric acid secretion [GO:0001696]; ion transport [GO:0006811]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719] GO:0001696; GO:0002064; GO:0005886; GO:0006811; GO:0015385; GO:0015386; GO:0016021; GO:0016323; GO:0016324; GO:0051453; GO:0071805; GO:0098719 0 0 0 PF00999;PF16644; Q6DIB5 CHOYP_MEG10.28.91 m.33845 sp MEG10_MOUSE 36.822 535 296 24 388 913 349 850 1.93E-68 251 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6GLJ1 CHOYP_LOC100376222.1.1 m.34587 sp BTBDH_XENLA 25.081 307 202 8 71 370 49 334 1.93E-26 115 BTBDH_XENLA reviewed BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) 470 0 GO:0005576 0 0 0 PF07707;PF00651; Q6IR68 CHOYP_LOC100178662.3.5 m.31389 sp THA11_XENLA 33.333 108 54 4 8 108 4 100 1.93E-07 56.6 THA11_XENLA reviewed THAP domain-containing protein 11 thap11 Xenopus laevis (African clawed frog) 298 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF05485; Q6TEK3 CHOYP_AAEL_AAEL011293.1.1 m.6619 sp VKORL_RAT 46.405 153 78 1 17 165 23 175 1.93E-43 145 VKORL_RAT reviewed Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4) Vkorc1l1 Rattus norvegicus (Rat) 176 cellular response to oxidative stress [GO:0034599]; peptidyl-glutamic acid carboxylation [GO:0017187]; vitamin K metabolic process [GO:0042373] GO:0005789; GO:0016021; GO:0017187; GO:0034599; GO:0042373; GO:0047057; GO:0048038 0 0 0 PF07884; Q7Z2W7 CHOYP_LOC100622032.1.3 m.47746 sp TRPM8_HUMAN 26.547 501 289 17 544 1004 561 1022 1.93E-38 160 TRPM8_HUMAN reviewed Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) 1104 calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955] GO:0005262; GO:0005789; GO:0005886; GO:0006874; GO:0009409; GO:0009897; GO:0016021; GO:0016048; GO:0045121; GO:0050955; GO:0051289; GO:0070207; GO:0070588 0 0 0 PF00520; Q86B91 CHOYP_DVIR_GJ23262.1.1 m.1974 sp TINC_DROME 32 200 121 4 201 397 670 857 1.93E-22 107 TINC_DROME reviewed Protein tincar tinc CG31247 Drosophila melanogaster (Fruit fly) 1513 regulation of eye photoreceptor cell development [GO:0042478] GO:0016021; GO:0042478 0 0 0 0 Q86U86 CHOYP_PB1.1.6 m.3775 sp PB1_HUMAN 37.725 167 77 6 1 159 1342 1489 1.93E-17 82.4 PB1_HUMAN reviewed Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 "chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0003682; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0008285; GO:0016569; GO:0090544 0 0 0 PF01426;PF00439;PF00505; Q8BNA6 CHOYP_FAT4.3.10 m.5638 sp FAT3_MOUSE 45.455 88 43 3 3 88 1226 1310 1.93E-12 64.7 FAT3_MOUSE reviewed Protocadherin Fat 3 (FAT tumor suppressor homolog 3) Fat3 Gm1132 Gm510 Mus musculus (Mouse) 4555 cell morphogenesis involved in differentiation [GO:0000904]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764]; retina layer formation [GO:0010842] GO:0000904; GO:0001764; GO:0005509; GO:0005886; GO:0007156; GO:0010842; GO:0016021; GO:0030425; GO:2000171 0 0 0 PF00028;PF02210; Q8CE96 CHOYP_LOC101078257.1.1 m.44069 sp TRM6_MOUSE 44.949 198 109 0 19 216 20 217 1.93E-48 171 TRM6_MOUSE reviewed tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) Trmt6 Kiaa1153 Trm6 Mus musculus (Mouse) 497 tRNA methylation [GO:0030488] GO:0005634; GO:0030488; GO:0031515; GO:0044822 0 0 0 PF04189; Q8K0U4 CHOYP_BRAFLDRAFT_208293.18.20 m.62808 sp HS12A_MOUSE 32.656 640 357 14 21 605 54 674 1.93E-102 328 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K0U4 CHOYP_HS12A.33.33 m.66569 sp HS12A_MOUSE 31.016 374 240 5 22 385 308 673 1.93E-54 193 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K2R5 CHOYP_ZN226.1.2 m.32220 sp ZN668_MOUSE 26.098 410 240 15 385 749 4 395 1.93E-23 109 ZN668_MOUSE reviewed Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q8TEW0 CHOYP_LOC100698856.1.1 m.41040 sp PARD3_HUMAN 39.973 743 358 22 3 716 1 684 1.93E-125 427 PARD3_HUMAN reviewed Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) 1356 asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell cycle [GO:0007049]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein complex assembly [GO:0006461]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein targeting to membrane [GO:0006612]; regulation of cellular localization [GO:0060341]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005546; GO:0005547; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005923; GO:0005938; GO:0006461; GO:0006612; GO:0007049; GO:0007163; GO:0007179; GO:0007205; GO:0007409; GO:0008356; GO:0010801; GO:0012505; GO:0022011; GO:0030054; GO:0031643; GO:0032266; GO:0033269; GO:0043025; GO:0043234; GO:0044295; GO:0060341; GO:0070830; GO:0090162 0 0 0 PF12053;PF00595; Q91XB0 CHOYP_TREX1.2.2 m.56505 sp TREX1_MOUSE 45.062 162 74 5 3 149 6 167 1.93E-29 121 TREX1_MOUSE reviewed Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III) Trex1 Mus musculus (Mouse) 314 cellular response to interferon-beta [GO:0035458]; DNA metabolic process [GO:0006259] GO:0003690; GO:0003697; GO:0005634; GO:0005789; GO:0005829; GO:0006259; GO:0008296; GO:0008408; GO:0008853; GO:0032405; GO:0032407; GO:0032558; GO:0035458; GO:0042803; GO:0046872 0 0 0 0 Q96IK5 CHOYP_GMCLL.1.1 m.15031 sp GMCL1_HUMAN 49.649 427 210 3 67 489 82 507 1.93E-147 440 GMCL1_HUMAN reviewed Germ cell-less protein-like 1 GMCL1 GCL Homo sapiens (Human) 515 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]" GO:0005635; GO:0006355; GO:0007275; GO:0007283; GO:0016363; GO:0030154 0 0 0 PF07707;PF00651; Q9BXJ3 CHOYP_BRAFLDRAFT_69134.13.13 m.66961 sp C1QT4_HUMAN 29.565 115 76 2 72 185 199 309 1.93E-08 56.2 C1QT4_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 4 C1QTNF4 CTRP4 Homo sapiens (Human) 329 0 GO:0005615 0 0 0 PF00386; Q9ES03 CHOYP_TBX20.4.4 m.56080 sp TBX20_MOUSE 62.09 335 88 6 24 342 10 321 1.93E-137 405 TBX20_MOUSE reviewed T-box transcription factor TBX20 (T-box protein 20) Tbx20 Tbx12 Mus musculus (Mouse) 445 "aortic valve development [GO:0003176]; aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; blood circulation [GO:0008015]; cardiac chamber formation [GO:0003207]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum development [GO:0003279]; cell proliferation [GO:0008283]; dorsal/ventral pattern formation [GO:0009953]; embryonic heart tube development [GO:0035050]; embryonic heart tube elongation [GO:0036306]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion formation [GO:0003272]; endocardial cushion morphogenesis [GO:0003203]; foramen ovale closure [GO:0035922]; heart looping [GO:0001947]; muscle contraction [GO:0006936]; negative regulation of SMAD protein complex assembly [GO:0010991]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; patterning of blood vessels [GO:0001569]; pericardium morphogenesis [GO:0003344]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pulmonary valve formation [GO:0003193]; pulmonary vein morphogenesis [GO:0060577]; regulation of epithelial to mesenchymal transition [GO:0010717]; tricuspid valve development [GO:0003175]; visceral motor neuron differentiation [GO:0021524]" GO:0000122; GO:0000977; GO:0000978; GO:0001077; GO:0001085; GO:0001102; GO:0001105; GO:0001569; GO:0001764; GO:0001947; GO:0003143; GO:0003148; GO:0003151; GO:0003175; GO:0003176; GO:0003180; GO:0003193; GO:0003203; GO:0003207; GO:0003215; GO:0003272; GO:0003279; GO:0003344; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006936; GO:0008015; GO:0008283; GO:0009953; GO:0010717; GO:0010991; GO:0021524; GO:0035050; GO:0035922; GO:0036306; GO:0045892; GO:0045893; GO:0045944; GO:0055008; GO:0060045; GO:0060413; GO:0060577 0 0 0 PF00907; Q9H892 CHOYP_TTC12.1.1 m.14571 sp TTC12_HUMAN 33.379 731 444 15 10 732 7 702 1.93E-116 369 TTC12_HUMAN reviewed Tetratricopeptide repeat protein 12 (TPR repeat protein 12) TTC12 Homo sapiens (Human) 705 0 GO:0005813 0 0 0 PF00515;PF13181; Q9N2M8 CHOYP_LOC100644701.1.2 m.50789 sp HDC_DROME 48.108 185 92 2 2 182 451 635 1.93E-58 200 HDC_DROME reviewed Headcase protein [Cleaved into: Headcase short protein] hdc CG15532 Drosophila melanogaster (Fruit fly) 1080 "axon extension [GO:0048675]; branch fusion, open tracheal system [GO:0035147]; imaginal disc-derived wing morphogenesis [GO:0007476]; instar larval or pupal development [GO:0002165]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; neurogenesis [GO:0022008]; regulation of neuron remodeling [GO:1904799]; RNA interference [GO:0016246]; salivary gland cell autophagic cell death [GO:0035071]; terminal branching, open tracheal system [GO:0007430]" GO:0002165; GO:0005737; GO:0007430; GO:0007476; GO:0016246; GO:0022008; GO:0030424; GO:0030425; GO:0035071; GO:0035147; GO:0035155; GO:0048471; GO:0048675; GO:0050768; GO:1904799 0 0 0 PF16002;PF15353; Q9NZ63 CHOYP_BRAFLDRAFT_63995.2.2 m.32318 sp CI078_HUMAN 51.93 285 125 6 12 287 8 289 1.93E-82 253 CI078_HUMAN reviewed Uncharacterized protein C9orf78 (Hepatocellular carcinoma-associated antigen 59) C9orf78 HCA59 Homo sapiens (Human) 289 0 GO:0005654; GO:0005737 0 0 0 PF07052; Q9V535 CHOYP_LOC100180193.1.2 m.7970 sp RBM8A_DROME 66.265 166 53 2 13 176 1 165 1.93E-76 228 RBM8A_DROME reviewed RNA-binding protein 8A (Protein tsunagi) tsu Y14 CG8781 Drosophila melanogaster (Fruit fly) 165 "epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of pole plasm mRNA localization [GO:0046595]; germarium-derived oocyte fate determination [GO:0007294]; microtubule cytoskeleton organization [GO:0000226]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transposition, DNA-mediated [GO:0000335]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte dorsal/ventral axis specification [GO:0007310]; oocyte nucleus migration involved in oocyte dorsal/ventral axis specification [GO:0007312]; pole plasm oskar mRNA localization [GO:0045451]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of pole plasm oskar mRNA localization [GO:0007317]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0000226; GO:0000335; GO:0000381; GO:0000398; GO:0003729; GO:0005634; GO:0005737; GO:0006406; GO:0007173; GO:0007294; GO:0007310; GO:0007312; GO:0007314; GO:0007317; GO:0008380; GO:0035145; GO:0045451; GO:0046595; GO:0071013 0 0 0 PF00076; A2RUV0 CHOYP_TRIADDRAFT_26633.4.6 m.50465 sp NOTC1_XENTR 36.722 482 267 17 71 539 403 859 1.94E-65 235 NOTC1_XENTR reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 2522 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001525; GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; B0JZG0 CHOYP_BRAFLDRAFT_83451.1.1 m.24348 sp S23A2_XENTR 44.578 581 306 5 3 579 65 633 1.94E-170 504 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; B1H228 CHOYP_BRAFLDRAFT_91528.1.1 m.49328 sp CC114_RAT 27.612 134 79 4 43 171 408 528 1.94E-09 59.7 CC114_RAT reviewed Coiled-coil domain-containing protein 114 Ccdc114 Rattus norvegicus (Rat) 694 cilium movement [GO:0003341]; outer dynein arm assembly [GO:0036158] GO:0003341; GO:0005929; GO:0036157; GO:0036158 0 0 0 0 B8JMH0 CHOYP_PDE6D.2.2 m.27698 sp CAF17_DANRE 44.934 227 111 7 19 240 132 349 1.94E-55 184 CAF17_DANRE reviewed "Putative transferase CAF17 homolog, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog)" iba57 ch1073-162b20.1 Danio rerio (Zebrafish) (Brachydanio rerio) 354 heme biosynthetic process [GO:0006783]; iron-sulfur cluster assembly [GO:0016226] GO:0005759; GO:0006783; GO:0016226; GO:0016740 0 0 0 PF01571;PF08669; F1M391 CHOYP_NEMVEDRAFT_V1G246111.2.2 m.52414 sp STING_RAT 27.368 190 110 6 526 697 154 333 1.94E-12 73.2 STING_RAT reviewed Stimulator of interferon genes protein (rSTING) (Transmembrane protein 173) Tmem173 Sting Rattus norvegicus (Rat) 379 "activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005789; GO:0005794; GO:0016021; GO:0032092; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; O14495 CHOYP_LPP3.1.2 m.38976 sp PLPP3_HUMAN 37.5 280 166 4 5 281 21 294 1.94E-54 183 PLPP3_HUMAN reviewed Phospholipid phosphatase 3 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) PLPP3 LPP3 PPAP2B Homo sapiens (Human) 311 Bergmann glial cell differentiation [GO:0060020]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion [GO:0044329]; canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration [GO:0044328]; canonical Wnt signaling pathway involved in positive regulation of wound healing [GO:0044330]; gastrulation with mouth forming second [GO:0001702]; germ cell migration [GO:0008354]; homotypic cell-cell adhesion [GO:0034109]; lipid metabolic process [GO:0006629]; negative regulation of protein phosphorylation [GO:0001933]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein stabilization [GO:0050821]; regulation of sphingolipid mediated signaling pathway [GO:1902068]; regulation of Wnt signaling pathway [GO:0030111]; sphingolipid biosynthetic process [GO:0030148] GO:0001568; GO:0001702; GO:0001933; GO:0004721; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0005912; GO:0006629; GO:0006644; GO:0008195; GO:0008354; GO:0016020; GO:0030111; GO:0030148; GO:0034109; GO:0042392; GO:0042577; GO:0044328; GO:0044329; GO:0044330; GO:0046839; GO:0050731; GO:0050821; GO:0051091; GO:0060020; GO:0070062; GO:1902068 0 0 0 PF01569; O88799 CHOYP_contig_038832 m.43948 sp ZAN_MOUSE 24.299 321 202 10 56 369 711 997 1.94E-06 55.5 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; P0C024 CHOYP_BRAFLDRAFT_63505.1.1 m.26922 sp NUDT7_HUMAN 32.692 208 133 2 18 222 10 213 1.94E-27 108 NUDT7_HUMAN reviewed Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7) NUDT7 Homo sapiens (Human) 238 acetyl-CoA catabolic process [GO:0046356]; brown fat cell differentiation [GO:0050873]; cellular lipid metabolic process [GO:0044255]; coenzyme A catabolic process [GO:0015938]; nucleoside diphosphate metabolic process [GO:0009132] GO:0000287; GO:0003986; GO:0005102; GO:0005777; GO:0005782; GO:0009132; GO:0015938; GO:0016289; GO:0016818; GO:0030145; GO:0030515; GO:0044255; GO:0046356; GO:0050873 0 0 0 PF00293; P21329 CHOYP_LOC100561123.17.28 m.23569 sp RTJK_DROFU 25.071 351 231 7 46 375 255 594 1.94E-21 99.8 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P21329 CHOYP_LOC752194.2.12 m.9270 sp RTJK_DROFU 23.322 283 199 7 1 273 599 873 1.94E-09 63.2 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P53753 CHOYP_LOC581748.1.1 m.47690 sp ENG1_YEAST 26.357 387 249 14 620 984 682 1054 1.94E-24 114 ENG1_YEAST reviewed "Endo-1,3(4)-beta-glucanase 1 (Endo-1,3-beta-glucanase 1) (Endo-1,4-beta-glucanase 1) (EC 3.2.1.6) (Daughter specific expression protein 4) (Laminarinase-1)" DSE4 ENG1 YNR067C N3547 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1117 (1->3)-beta-D-glucan catabolic process [GO:0006076]; cell separation after cytokinesis [GO:0000920] GO:0000920; GO:0005576; GO:0006076; GO:0009277; GO:0009986; GO:0030428; GO:0042973; GO:0052861; GO:0052862 0 0 0 PF03639; P62184 CHOYP_contig_025601 m.29197 sp CALM_RENRE 41.333 150 86 1 1 150 1 148 1.94E-38 130 CALM_RENRE reviewed Calmodulin (CaM) 0 Renilla reniformis (Sea pansy) 149 0 GO:0005509 0 0 0 PF13499; Q07120 CHOYP_LOC100366473.1.1 m.10897 sp GFI1_RAT 82.635 167 29 0 189 355 254 420 1.94E-97 299 GFI1_RAT reviewed Zinc finger protein Gfi-1 (Growth factor independent protein 1) Gfi1 Gfi-1 Rattus norvegicus (Rat) 423 "cellular response to lipopolysaccharide [GO:0071222]; myeloid cell differentiation [GO:0030099]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of interleukin-6-mediated signaling pathway [GO:0070105]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of neurogenesis [GO:0050767]; regulation of toll-like receptor signaling pathway [GO:0034121]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001078; GO:0006351; GO:0010956; GO:0010977; GO:0016363; GO:0016604; GO:0017053; GO:0030099; GO:0034121; GO:0044212; GO:0046872; GO:0050767; GO:0051569; GO:0070105; GO:0071222 0 0 0 PF00096;PF13912; Q11179 CHOYP_BRAFLDRAFT_88155.1.1 m.22370 sp YPC2_CAEEL 62.117 359 133 2 1 357 1 358 1.94E-168 489 YPC2_CAEEL reviewed Putative serine/threonine-protein kinase C05D10.2 (EC 2.7.11.24) C05D10.2 Caenorhabditis elegans 470 0 GO:0004707; GO:0005524; GO:0005622 0 0 0 PF00069; Q15147 CHOYP_PLCB4.2.2 m.24258 sp PLCB4_HUMAN 54.237 118 50 2 1 116 1 116 1.94E-35 133 PLCB4_HUMAN reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)" PLCB4 Homo sapiens (Human) 1175 inositol phosphate metabolic process [GO:0043647]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; negative regulation of potassium ion transport [GO:0043267] GO:0004435; GO:0004629; GO:0004871; GO:0005509; GO:0005634; GO:0005790; GO:0005829; GO:0014069; GO:0016042; GO:0030425; GO:0035556; GO:0043267; GO:0043647 0 0 0 PF00168;PF06631;PF09279;PF00388;PF00387; Q24563 CHOYP_DOPR2.1.1 m.18337 sp DOPR2_DROME 46.384 401 174 8 78 451 122 508 1.94E-97 306 DOPR2_DROME reviewed Dopamine receptor 2 (Dopamine 1-like receptor 2) Dop1R2 DAMB DopR2 DopR99B CG18741 Drosophila melanogaster (Fruit fly) 539 "adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; age-dependent response to oxidative stress [GO:0001306]; dopamine receptor signaling pathway [GO:0007212]; G-protein coupled receptor signaling pathway [GO:0007186]; learning [GO:0007612]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; response to odorant [GO:1990834]; synaptic transmission, dopaminergic [GO:0001963]" GO:0001306; GO:0001588; GO:0001963; GO:0004935; GO:0004952; GO:0005886; GO:0005887; GO:0007186; GO:0007191; GO:0007212; GO:0007612; GO:0008226; GO:0008227; GO:0016021; GO:0030285; GO:0035240; GO:0060158; GO:0099509; GO:1903223; GO:1990834 0 0 0 PF00001; Q28691 CHOYP_BRAFLDRAFT_126347.1.2 m.7261 sp PE2R4_RABIT 34.375 352 166 5 9 298 4 352 1.94E-60 204 PE2R4_RABIT reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Oryctolagus cuniculus (Rabbit) 488 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624] GO:0004957; GO:0005886; GO:0007188; GO:0016021; GO:0033624; GO:0050728; GO:2000420 0 0 0 PF00001; Q2PW47 CHOYP_MED24.4.10 m.16708 sp MED24_DANRE 32.939 1014 616 19 20 1002 6 986 1.94E-168 523 MED24_DANRE reviewed Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Protein lessen) (Thyroid hormone receptor-associated protein 4 homolog) (Trap100 homolog) med24 lsn thrap4 trap100 Danio rerio (Zebrafish) (Brachydanio rerio) 989 "enteric nervous system development [GO:0048484]; interstitial cell of Cajal differentiation [GO:0061453]; retinal cone cell development [GO:0046549]; thymus development [GO:0048538]; transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592; GO:0046549; GO:0048484; GO:0048538; GO:0061453 0 0 0 PF11277; Q2T9U5 CHOYP_LOC660590.1.1 m.26950 sp REXON_BOVIN 37.318 343 182 10 127 464 70 384 1.94E-47 182 REXON_BOVIN reviewed Putative RNA exonuclease NEF-sp (EC 3.1.-.-) 0 Bos taurus (Bovine) 783 0 GO:0000166; GO:0003723; GO:0004527; GO:0005730; GO:0070062 0 0 0 PF00929;PF00076; Q3MHY8 CHOYP_LOC100476004.1.1 m.25594 sp RBM7_BOVIN 47.059 119 58 3 5 119 9 126 1.94E-27 106 RBM7_BOVIN reviewed RNA-binding protein 7 (RNA-binding motif protein 7) RBM7 Bos taurus (Bovine) 262 meiotic cell cycle [GO:0051321] GO:0000166; GO:0003723; GO:0051321 0 0 0 PF00076; Q3SZ21 CHOYP_RPP30.1.1 m.30061 sp RPP30_BOVIN 33.871 248 106 7 19 223 4 236 1.94E-26 107 RPP30_BOVIN reviewed Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2) RPP30 RNASEP2 Bos taurus (Bovine) 268 "RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; tRNA processing [GO:0008033]" GO:0003723; GO:0004526; GO:0005655; GO:0008033; GO:0090502 0 0 0 PF01876; Q460N5 CHOYP_SI_CH211-219A4.3.1.2 m.15413 sp PAR14_HUMAN 35.714 84 47 2 1 80 896 976 1.94E-06 48.9 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5D0K2 CHOYP_BRAFLDRAFT_77391.1.3 m.26164 sp CCKAR_CANLF 23.529 391 248 14 68 443 24 378 1.94E-10 66.2 CCKAR_CANLF reviewed Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Canis lupus familiaris (Dog) (Canis familiaris) 428 axonogenesis [GO:0007409]; cholecystokinin signaling pathway [GO:0038188]; digestion [GO:0007586]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; neuron migration [GO:0001764]; regulation of hormone secretion [GO:0046883] GO:0001764; GO:0004951; GO:0005886; GO:0007409; GO:0007586; GO:0007631; GO:0016021; GO:0030900; GO:0038188; GO:0046883 0 0 0 PF00001;PF09193; Q62158 CHOYP_LOC100374741.34.83 m.32918 sp TRI27_MOUSE 26.852 216 124 8 40 233 70 273 1.94E-06 52.8 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q6AY22 CHOYP_LOC100374267.1.5 m.12369 sp SPAT1_RAT 31.049 467 292 9 19 483 6 444 1.94E-53 189 SPAT1_RAT reviewed Spermatogenesis-associated protein 1 Spata1 Rattus norvegicus (Rat) 444 0 0 0 0 0 PF15743; Q6UX73 CHOYP_BRAFLDRAFT_126823.1.1 m.41468 sp CP089_HUMAN 28.044 271 165 10 43 306 40 287 1.94E-22 103 CP089_HUMAN reviewed UPF0764 protein C16orf89 C16orf89 UNQ904/PRO1925 Homo sapiens (Human) 402 0 GO:0005829; GO:0016020; GO:0042803; GO:0070062 0 0 0 PF15882; Q8C6L5 CHOYP_NEMVEDRAFT_V1G196611.9.13 m.34646 sp CGAS_MOUSE 24.201 219 141 7 138 334 265 480 1.94E-08 60.8 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8JHV9 CHOYP_BIRC7.2.5 m.4701 sp BIR7A_XENLA 28.706 425 225 9 17 429 43 401 1.94E-48 173 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8K0U4 CHOYP_HS12B.5.14 m.35125 sp HS12A_MOUSE 32.132 638 359 16 12 594 56 674 1.94E-92 302 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8WZ42 CHOYP_contig_024424 m.27774 sp TITIN_HUMAN 24.808 1044 627 37 861 1844 4302 5247 1.94E-31 140 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q92544 CHOYP_ISCW_ISCW010750.1.1 m.27440 sp TM9S4_HUMAN 81.89 127 23 0 1 127 516 642 1.94E-67 217 TM9S4_HUMAN reviewed Transmembrane 9 superfamily member 4 TM9SF4 KIAA0255 Homo sapiens (Human) 642 0 GO:0016021 0 0 0 PF02990; Q98938 CHOYP_PHUM_PHUM018090.1.1 m.10719 sp IHH_CHICK 48.964 386 189 4 23 405 19 399 1.94E-132 389 IHH_CHICK reviewed Indian hedgehog protein (IHH) [Cleaved into: Indian hedgehog protein N-product; Indian hedgehog protein C-product] IHH Gallus gallus (Chicken) 408 cartilage development [GO:0051216]; cell-cell signaling [GO:0007267]; chondroblast differentiation [GO:0060591]; chondrocyte proliferation [GO:0035988]; embryonic digit morphogenesis [GO:0042733]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of chondrocyte hypertrophy [GO:1903042]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of cell morphogenesis involved in differentiation [GO:0010770]; positive regulation of gene expression [GO:0010628]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of osteoblast differentiation [GO:0045669]; proteoglycan biosynthetic process [GO:0030166]; regulation of chondrocyte differentiation involved in endochondral bone morphogenesis [GO:1902738]; regulation of growth plate cartilage chondrocyte differentiation [GO:1902733]; regulation of growth plate cartilage chondrocyte proliferation [GO:0003420] GO:0003420; GO:0005615; GO:0005622; GO:0005886; GO:0007228; GO:0007267; GO:0008233; GO:0010628; GO:0010694; GO:0010770; GO:0030166; GO:0032331; GO:0035988; GO:0042733; GO:0045669; GO:0046872; GO:0051216; GO:0060591; GO:1902733; GO:1902738; GO:1903042 0 0 0 PF01085;PF01079; Q9BQG0 CHOYP_BRAFLDRAFT_84237.1.1 m.1879 sp MBB1A_HUMAN 24.612 1288 831 42 8 1217 30 1255 1.94E-46 186 MBB1A_HUMAN reviewed Myb-binding protein 1A MYBBP1A P160 Homo sapiens (Human) 1328 "cellular response to glucose starvation [GO:0042149]; circadian regulation of gene expression [GO:0032922]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleocytoplasmic transport [GO:0006913]; osteoblast differentiation [GO:0001649]; positive regulation of anoikis [GO:2000210]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of transcription, DNA-templated [GO:0006355]; respiratory electron transport chain [GO:0022904]; transcription, DNA-templated [GO:0006351]" GO:0001047; GO:0001649; GO:0003714; GO:0003887; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0006913; GO:0008134; GO:0016020; GO:0022904; GO:0032922; GO:0042149; GO:0042564; GO:0043231; GO:0043565; GO:0044822; GO:0045815; GO:0045892; GO:0071158; GO:0072332; GO:2000210 0 0 0 PF04931; Q9EPQ1 CHOYP_TLR2.7.7 m.57155 sp TLR1_MOUSE 24.632 272 180 9 30 286 504 765 1.94E-15 79.7 TLR1_MOUSE reviewed Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Tlr1 Mus musculus (Mouse) 795 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; detection of triacyl bacterial lipopeptide [GO:0042495]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 1 signaling pathway [GO:0034130]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0002755; GO:0004888; GO:0005794; GO:0005887; GO:0006952; GO:0006954; GO:0007250; GO:0016020; GO:0030670; GO:0034130; GO:0035354; GO:0035355; GO:0035663; GO:0042116; GO:0042495; GO:0042497; GO:0042535; GO:0042742; GO:0045087; GO:0045121; GO:0045335; GO:0045410; GO:0046982; GO:0050707; GO:0071723; GO:0071726; GO:0071727 0 0 0 PF12799;PF13855;PF01582; Q9H8W5 CHOYP_LOC100369929.3.5 m.36958 sp TRI45_HUMAN 24.413 213 135 5 12 214 133 329 1.94E-10 65.9 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9MYM7 CHOYP_B3GN5.2.4 m.35685 sp B3GT1_PONPY 37.358 265 151 8 81 340 61 315 1.94E-50 174 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9P959 CHOYP_NEMVEDRAFT_V1G203646.1.1 m.26284 sp AOX_EMENI 53.846 130 58 2 2 129 195 324 1.94E-47 159 AOX_EMENI reviewed "Alternative oxidase, mitochondrial (EC 1.-.-.-)" alxA aod-1 AN2099 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 354 0 GO:0005739; GO:0005743; GO:0009916; GO:0016021; GO:0046872; GO:0070469 0 0 0 PF01786; Q9UJG1 CHOYP_BRAFLDRAFT_277118.1.1 m.15608 sp MSPD1_HUMAN 52.632 209 94 2 27 235 8 211 1.94E-70 217 MSPD1_HUMAN reviewed Motile sperm domain-containing protein 1 MOSPD1 Homo sapiens (Human) 213 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000122; GO:0005634; GO:0005737; GO:0016021; GO:0045944; GO:0048471 0 0 0 PF00635; Q9Y2F9 CHOYP_LOC100375232.1.2 m.2686 sp BTBD3_HUMAN 31.294 425 275 8 16 430 98 515 1.94E-55 194 BTBD3_HUMAN reviewed BTB/POZ domain-containing protein 3 BTBD3 KIAA0952 Homo sapiens (Human) 522 cerebral cortex development [GO:0021987]; dendrite morphogenesis [GO:0048813]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of proteolysis [GO:0030162] GO:0005634; GO:0005829; GO:0019005; GO:0021987; GO:0030162; GO:0031625; GO:0042787; GO:0043161; GO:0048813 0 0 0 PF07707;PF00651;PF08005; A1Z9X0 CHOYP_LOC100533284.2.2 m.44774 sp APKC_DROME 85.405 185 27 0 9 193 257 441 1.95E-114 342 APKC_DROME reviewed Atypical protein kinase C (EC 2.7.11.13) aPKC CG30475 Drosophila melanogaster (Fruit fly) 606 "adherens junction organization [GO:0034332]; apical protein localization [GO:0045176]; asymmetric neuroblast division [GO:0055059]; asymmetric protein localization involved in cell fate determination [GO:0045167]; branching involved in open tracheal system development [GO:0060446]; cell-cell junction assembly [GO:0007043]; compound eye retinal cell programmed cell death [GO:0046667]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of epithelial cell planar polarity [GO:0090163]; establishment of mitotic spindle orientation [GO:0000132]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of neuroblast polarity [GO:0045196]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; exocyst localization [GO:0051601]; germarium-derived oocyte fate determination [GO:0007294]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; melanotic encapsulation of foreign target [GO:0035011]; memory [GO:0007613]; morphogenesis of a polarized epithelium [GO:0001738]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte axis specification [GO:0007309]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuroblast proliferation [GO:0002052]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; sensory organ development [GO:0007423]; spermatogenesis [GO:0007283]; synapse assembly [GO:0007416]; terminal branching, open tracheal system [GO:0007430]; zonula adherens assembly [GO:0045186]" GO:0000132; GO:0001738; GO:0002052; GO:0003382; GO:0004674; GO:0004697; GO:0005524; GO:0005938; GO:0006468; GO:0007043; GO:0007163; GO:0007283; GO:0007294; GO:0007309; GO:0007314; GO:0007416; GO:0007423; GO:0007430; GO:0007613; GO:0010592; GO:0016324; GO:0016327; GO:0016332; GO:0016334; GO:0017022; GO:0030011; GO:0034332; GO:0035003; GO:0035011; GO:0035556; GO:0045167; GO:0045176; GO:0045179; GO:0045186; GO:0045196; GO:0045197; GO:0045198; GO:0046667; GO:0046872; GO:0051491; GO:0051601; GO:0055059; GO:0060446; GO:0072659; GO:0090163 0 0 0 PF00130;PF00564;PF00069;PF00433; A4FUP9 CHOYP_GL1D1.1.3 m.36979 sp GL1D1_MOUSE 38.647 207 126 1 7 213 136 341 1.95E-48 165 GL1D1_MOUSE reviewed Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) Glt1d1 Mus musculus (Mouse) 346 0 GO:0005576; GO:0005737; GO:0016757 0 0 0 PF00534; A5D7L5 CHOYP_S39AE.2.3 m.25498 sp S39AE_BOVIN 37.743 514 269 15 25 521 11 490 1.95E-100 314 S39AE_BOVIN reviewed Zinc transporter ZIP14 (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) SLC39A14 ZIP14 Bos taurus (Bovine) 490 cellular zinc ion homeostasis [GO:0006882]; zinc II ion transmembrane import [GO:0071578]; zinc II ion transmembrane transport [GO:0071577] GO:0005385; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0006882; GO:0015093; GO:0071577; GO:0071578 0 0 0 PF02535; B3EWZ3 CHOYP_BRAFLDRAFT_85664.3.10 m.26597 sp CADN_ACRMI 35.275 309 178 10 1213 1510 219 516 1.95E-30 135 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; D8VNS7 CHOYP_BRAFLDRAFT_86061.3.13 m.23192 sp FCNV1_CERRY 53.333 180 80 2 87 265 128 304 1.95E-61 201 FCNV1_CERRY reviewed Ryncolin-1 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; H2A0L1 CHOYP_TYRO1.3.6 m.43932 sp TYRO2_PINMG 33.448 290 156 9 130 394 71 348 1.95E-34 136 TYRO2_PINMG reviewed Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) 0 Pinctada margaritifera (Black-lipped pearl oyster) 456 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; O13008 CHOYP_LOC100533521.2.2 m.52097 sp FABPH_ONCMY 40.876 137 74 3 1 136 1 131 1.95E-19 81.3 FABPH_ONCMY reviewed "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP)" fabp3 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 133 0 GO:0005215; GO:0005737; GO:0008289 0 0 0 PF00061; O62640 CHOYP_PIAP.2.3 m.50441 sp PIAP_PIG 28.947 228 133 6 1 213 144 357 1.95E-26 107 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; O75382 CHOYP_BRAFLDRAFT_69765.1.23 m.3568 sp TRIM3_HUMAN 21.818 275 180 12 299 554 486 744 1.95E-06 54.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_88224.3.11 m.4347 sp TRIM3_HUMAN 21.678 286 190 6 282 551 475 742 1.95E-08 60.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O83041 CHOYP_CAOG_02976.2.2 m.56777 sp PIP_LEPBY 62.179 312 118 0 20 331 1 312 1.95E-144 413 PIP_LEPBY reviewed Probable proline iminopeptidase (PIP) (EC 3.4.11.5) (Prolyl aminopeptidase) (PAP) pip Leptolyngbya boryana (Plectonema boryanum) 321 0 GO:0004177; GO:0005737 0 0 0 PF00561; O94739 CHOYP_CALMB.1.1 m.41570 sp CALM_PLEOS 86.916 107 14 0 806 912 43 149 1.95E-59 202 CALM_PLEOS reviewed Calmodulin (CaM) CMD1 Pleurotus ostreatus (Oyster mushroom) (White-rot fungus) 149 0 GO:0005509 0 0 0 PF13499; P02467 CHOYP_LOC100377585.3.3 m.63266 sp CO1A2_CHICK 51.087 92 39 1 76 161 904 995 1.95E-13 71.6 CO1A2_CHICK reviewed Collagen alpha-2(I) chain (Alpha-2 type I collagen) (Fragments) COL1A2 Gallus gallus (Chicken) 1362 0 GO:0005201; GO:0005583; GO:0046872 0 0 0 PF01410;PF01391; P18433 CHOYP_PTPRA.1.22 m.487 sp PTPRA_HUMAN 32.252 493 293 17 455 922 134 610 1.95E-56 212 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P22292 CHOYP_M2OM.1.1 m.11786 sp M2OM_BOVIN 71.672 293 82 1 36 327 20 312 1.95E-151 431 M2OM_BOVIN reviewed Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11) SLC25A11 SLC20A4 Bos taurus (Bovine) 314 translation [GO:0006412]; transport [GO:0006810] GO:0003735; GO:0005634; GO:0005739; GO:0005743; GO:0006412; GO:0006810; GO:0016021; GO:0044822 0 0 0 PF00153; P45842 CHOYP_NEMVEDRAFT_V1G237122.5.6 m.44606 sp RL34_AEDAL 71.429 112 31 1 16 127 1 111 1.95E-49 157 RL34_AEDAL reviewed 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01199; P49415 CHOYP_NID2.2.2 m.56022 sp SDC_DROME 68.182 66 18 2 323 385 334 399 1.95E-17 86.7 SDC_DROME reviewed Syndecan Sdc Syd CG10497 Drosophila melanogaster (Fruit fly) 399 "axon guidance [GO:0007411]; detection of light stimulus involved in visual perception [GO:0050908]; energy homeostasis [GO:0097009]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell development [GO:0021782]; motor neuron axon guidance [GO:0008045]; muscle organ development [GO:0007517]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; regulation of multicellular organismal metabolic process [GO:0044246]" GO:0005886; GO:0005925; GO:0007411; GO:0007427; GO:0007517; GO:0008045; GO:0009986; GO:0016021; GO:0021782; GO:0031594; GO:0044246; GO:0045202; GO:0045887; GO:0050908; GO:0097009; GO:0098595; GO:2000637 0 0 0 PF01034; P59222 CHOYP_LOC100371242.3.6 m.39821 sp SREC2_MOUSE 38.272 162 94 5 196 355 227 384 1.95E-21 99.4 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P79145 CHOYP_CREM.1.1 m.12267 sp CREM_CANLF 52.229 314 110 12 1 283 54 358 1.95E-82 255 CREM_CANLF reviewed cAMP-responsive element modulator CREM Canis lupus familiaris (Dog) (Canis familiaris) 360 "circadian regulation of gene expression [GO:0032922]; glycosphingolipid metabolic process [GO:0006687]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cAMP [GO:0051591]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0001046; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006687; GO:0007283; GO:0032922; GO:0045892; GO:0045944; GO:0051591 0 0 0 PF00170;PF02173; Q02645 CHOYP_ADD.1.5 m.12448 sp HTS_DROME 46.777 543 247 9 21 535 74 602 1.95E-165 508 HTS_DROME reviewed Protein hu-li tai shao (Adducin-like protein) hts CG9325 Drosophila melanogaster (Fruit fly) 1156 "actin filament bundle organization [GO:0061572]; adult somatic muscle development [GO:0007527]; axon guidance [GO:0007411]; centrosome organization [GO:0051297]; cystoblast division [GO:0007282]; female germ-line cyst formation [GO:0048135]; female germline ring canal formation, actin assembly [GO:0008302]; fusome organization [GO:0045478]; germarium-derived oocyte fate determination [GO:0007294]; germ-line cyst formation [GO:0048134]; locomotion involved in locomotory behavior [GO:0031987]; meiotic spindle organization [GO:0000212]; neuron cellular homeostasis [GO:0070050]; oogenesis [GO:0048477]; ovarian fusome organization [GO:0030723]; photoreceptor cell axon guidance [GO:0072499]; sarcomere organization [GO:0045214]; spectrosome organization [GO:0030721]; testicular fusome organization [GO:0030724]" GO:0000212; GO:0005737; GO:0005811; GO:0005856; GO:0005886; GO:0007282; GO:0007294; GO:0007411; GO:0007527; GO:0008302; GO:0016328; GO:0030721; GO:0030723; GO:0030724; GO:0031987; GO:0035183; GO:0045169; GO:0045170; GO:0045172; GO:0045214; GO:0045478; GO:0048134; GO:0048135; GO:0048477; GO:0051297; GO:0061572; GO:0070050; GO:0072499 0 0 0 PF00596; Q09811 CHOYP_LOC100370129.3.4 m.37587 sp HUS2_SCHPO 33.117 154 91 4 5 146 506 659 1.95E-14 72.4 HUS2_SCHPO reviewed ATP-dependent DNA helicase hus2/rqh1 (EC 3.6.4.12) rqh1 hus2 rad12 rec9 SPAC2G11.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1328 cellular response to DNA damage stimulus [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; intra-S DNA damage checkpoint [GO:0031573]; maintenance of rDNA [GO:0043007]; mitotic recombination-dependent replication fork processing [GO:1990426]; postreplication repair [GO:0006301]; recombinational repair [GO:0000725]; regulation of mitotic recombination involved in replication fork processing [GO:1903221]; replication fork processing at rDNA locus [GO:0034065]; resolution of mitotic recombination intermediates [GO:0071140]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914] GO:0000228; GO:0000723; GO:0000724; GO:0000725; GO:0003677; GO:0005524; GO:0005730; GO:0005737; GO:0006301; GO:0006974; GO:0009378; GO:0031422; GO:0031573; GO:0032508; GO:0034065; GO:0035861; GO:0043007; GO:0043140; GO:0070914; GO:0071140; GO:1903221; GO:1990426 0 0 0 PF00270;PF00271;PF00570;PF16124;PF09382; Q0VCW3 CHOYP_LOC100376508.1.1 m.55382 sp BANP_BOVIN 41.928 415 162 12 116 459 34 440 1.95E-85 275 BANP_BOVIN reviewed Protein BANP BANP Bos taurus (Bovine) 503 "cell cycle [GO:0007049]; covalent chromatin modification [GO:0016569]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007049; GO:0007275; GO:0016569 0 0 0 PF10523; Q13310 CHOYP_PHUM_PHUM617090.1.1 m.66270 sp PABP4_HUMAN 54.378 217 81 5 1 205 219 429 1.95E-64 213 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q2NKQ1 CHOYP_SGSM1.2.2 m.59182 sp SGSM1_HUMAN 83.099 213 36 0 1 213 924 1136 1.95E-129 400 SGSM1_HUMAN reviewed Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2) SGSM1 KIAA1941 RUTBC2 Homo sapiens (Human) 1148 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0005737; GO:0005794; GO:0005829; GO:0006886; GO:0012505; GO:0017137; GO:0030659; GO:0031338; GO:0090630 0 0 0 PF00566;PF02759; Q32L27 CHOYP_BRAFLDRAFT_68488.1.1 m.58466 sp UB2Q2_BOVIN 31.373 204 127 8 164 361 138 334 1.95E-20 94.4 UB2Q2_BOVIN reviewed Ubiquitin-conjugating enzyme E2 Q2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q2) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2) UBE2Q2 Bos taurus (Bovine) 342 protein K48-linked ubiquitination [GO:0070936] GO:0004842; GO:0005524; GO:0005737; GO:0061631; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q58DU5 CHOYP_BRAFLDRAFT_264234.2.2 m.7062 sp PSA3_BOVIN 74.118 255 66 0 1 255 1 255 1.95E-143 405 PSA3_BOVIN reviewed Proteasome subunit alpha type-3 (EC 3.4.25.1) PSMA3 Bos taurus (Bovine) 255 ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0006511; GO:0019773; GO:0070062 0 0 0 PF00227;PF10584; Q5BIM1 CHOYP_LOC100213744.7.19 m.33062 sp TRI45_BOVIN 28.862 246 168 4 5 244 127 371 1.95E-16 85.9 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5FWI3 CHOYP_TMEM2.2.4 m.8174 sp TMEM2_MOUSE 28.04 1102 656 41 44 1054 123 1178 1.95E-105 364 TMEM2_MOUSE reviewed Transmembrane protein 2 Tmem2 Kiaa1412 Mus musculus (Mouse) 1383 multicellular organism development [GO:0007275] GO:0007275; GO:0016021; GO:0070062 0 0 0 PF10162; Q5HZL9 CHOYP_ACA1_370240.1.1 m.10015 sp HDHD3_XENLA 35.294 221 136 3 4 218 3 222 1.95E-43 149 HDHD3_XENLA reviewed Haloacid dehalogenase-like hydrolase domain-containing protein 3 hdhd3 Xenopus laevis (African clawed frog) 244 metabolic process [GO:0008152] GO:0008152; GO:0016787 0 0 0 PF13419; Q5ND28 CHOYP_MEG10.57.91 m.47522 sp SREC_MOUSE 37.692 130 76 4 169 296 215 341 1.95E-17 85.9 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5PQN9 CHOYP_LOC100741487.1.1 m.10928 sp RM38_RAT 42.063 378 204 9 1 370 1 371 1.95E-91 284 RM38_RAT reviewed "39S ribosomal protein L38, mitochondrial (L38mt) (MRP-L38)" Mrpl38 Rattus norvegicus (Rat) 380 0 GO:0005739; GO:0005840 0 0 0 PF01161; Q5RCY5 CHOYP_LOC100371041.1.1 m.14494 sp ASTE1_PONAB 20.648 494 349 10 2 490 198 653 1.95E-29 126 ASTE1_PONAB reviewed Protein asteroid homolog 1 ASTE1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 679 DNA repair [GO:0006281] GO:0004518; GO:0006281 0 0 0 PF00752; Q5XX13 CHOYP_LOC589839.1.1 m.29309 sp FBW10_HUMAN 34.188 702 430 8 29 708 1 692 1.95E-144 467 FBW10_HUMAN reviewed F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor) FBXW10 Homo sapiens (Human) 1052 0 0 0 0 0 PF00400; Q61103 CHOYP_DPF2.1.2 m.6678 sp REQU_MOUSE 46.683 407 164 9 1 385 1 376 1.95E-100 306 REQU_MOUSE reviewed "Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)" Dpf2 Baf45d Req Ubid4 Mus musculus (Mouse) 391 "apoptotic process [GO:0006915]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000790; GO:0000978; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006351; GO:0006355; GO:0006915; GO:0008270; GO:0043231; GO:0090544 0 0 0 PF00628;PF14051; Q640K1 CHOYP_NCDN.1.1 m.58381 sp NCDN_XENLA 33.744 406 258 6 6 408 17 414 1.95E-59 219 NCDN_XENLA reviewed Neurochondrin ncdn Xenopus laevis (African clawed frog) 720 neuron projection development [GO:0031175] GO:0005829; GO:0030425; GO:0031175; GO:0043025 0 0 0 PF05536; Q64707 CHOYP_ZRSR2.1.1 m.29410 sp U2AFL_MOUSE 45.455 363 182 4 88 438 52 410 1.95E-82 268 U2AFL_MOUSE reviewed "U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1)" Zrsr1 Sp2 Sp2-7 U2af1-rs1 U2af1l1 Mus musculus (Mouse) 428 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0030529; GO:0046872; GO:0089701 0 0 0 PF00076;PF00642; Q66S25 CHOYP_CG32633.1.1 m.59265 sp NATT1_THANI 29.861 144 83 7 3 141 37 167 1.95E-07 52 NATT1_THANI reviewed Natterin-1 (EC 3.4.-.-) 0 Thalassophryne nattereri (Niquim) 355 0 GO:0005576; GO:0016787 0 0 0 PF11901; Q6GPQ3 CHOYP_MFSD8.1.1 m.3957 sp MFSD8_XENLA 50.29 517 230 8 20 529 8 504 1.95E-168 489 MFSD8_XENLA reviewed Major facilitator superfamily domain-containing protein 8 mfsd8 Xenopus laevis (African clawed frog) 510 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6GR16 CHOYP_LOC100370010.4.5 m.25252 sp EPABB_XENLA 58.156 141 59 0 6 146 485 625 1.95E-42 152 EPABB_XENLA reviewed Embryonic polyadenylate-binding protein B (Embryonic poly(A)-binding protein B) (ePAB-B) (ePABP-B) (XePABP-B) epabp-b Xenopus laevis (African clawed frog) 629 chordate embryonic development [GO:0043009]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; translation [GO:0006412] GO:0000166; GO:0005737; GO:0006397; GO:0006412; GO:0008143; GO:0031370; GO:0043009; GO:0043621; GO:0048255; GO:0060212 0 0 0 PF00658;PF00076; Q6NZJ6 CHOYP_IF4G1.2.2 m.37351 sp IF4G1_MOUSE 48.889 180 72 5 30 192 698 874 1.95E-41 152 IF4G1_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) Eif4g1 Mus musculus (Mouse) 1600 behavioral fear response [GO:0001662]; positive regulation of neuron differentiation [GO:0045666]; regulation of translational initiation [GO:0006446] GO:0001662; GO:0003743; GO:0005737; GO:0006446; GO:0008190; GO:0016020; GO:0044822; GO:0045666 0 0 0 PF02847;PF02854;PF02020; Q75T13 CHOYP_BRAFLDRAFT_279100.1.1 m.13813 sp PGAP1_HUMAN 36.667 570 332 11 1 563 32 579 1.95E-128 401 PGAP1_HUMAN reviewed GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) (hPGAP1) PGAP1 UNQ3024/PRO9822 Homo sapiens (Human) 922 anterior/posterior axis specification [GO:0009948]; attachment of GPI anchor to protein [GO:0016255]; embryonic pattern specification [GO:0009880]; forebrain regionalization [GO:0021871]; myo-inositol transport [GO:0015798]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605] GO:0004518; GO:0005783; GO:0005789; GO:0007605; GO:0009880; GO:0009948; GO:0015031; GO:0015798; GO:0016021; GO:0016255; GO:0016788; GO:0021871; GO:0042578 0 0 0 PF07819; Q8BWW9 CHOYP_BRAFLDRAFT_59608.1.1 m.23225 sp PKN2_MOUSE 87.097 155 20 0 1 155 699 853 1.95E-89 284 PKN2_MOUSE reviewed Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) Pkn2 Prk2 Prkcl2 Mus musculus (Mouse) 983 "apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0004674; GO:0004697; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005886; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0007049; GO:0007155; GO:0010631; GO:0016301; GO:0018105; GO:0030027; GO:0030054; GO:0030496; GO:0032154; GO:0032467; GO:0035556; GO:0042826; GO:0043234; GO:0043296; GO:0043297; GO:0044822; GO:0045070; GO:0045111; GO:0045931; GO:0048471; GO:0051301; GO:0070063; GO:2000145 0 0 0 PF02185;PF00069;PF00433; Q8IYB1 CHOYP_MAB21.1.1 m.39225 sp M21D2_HUMAN 27.624 181 115 7 188 364 243 411 1.95E-09 64.3 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8K4L3 CHOYP_LOC100367546.1.1 m.26283 sp SVIL_MOUSE 36.634 101 54 3 88 178 1082 1182 1.95E-08 57.4 SVIL_MOUSE reviewed Supervillin (Archvillin) (p205/p250) Svil Mus musculus (Mouse) 2170 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] GO:0002102; GO:0005634; GO:0005737; GO:0005886; GO:0005925; GO:0007010; GO:0007519; GO:0015629; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0043034; GO:0051015; GO:0071437 0 0 0 PF00626;PF02209; Q8NUZ4 CHOYP_contig_016048 m.18810 sp FLP_STAAW 27 200 117 5 70 267 44 216 1.95E-10 67.4 FLP_STAAW reviewed Protein flp (FmtA-like protein) flp MW2365 Staphylococcus aureus (strain MW2) 498 0 GO:0005886; GO:0016021 0 0 0 PF00144; Q8QHL5 CHOYP_PHC2.1.1 m.48379 sp PHC2_DANRE 43.522 301 127 10 610 886 544 825 1.95E-56 212 PHC2_DANRE reviewed Polyhomeotic-like protein 2 phc2 edr2 ph2 Danio rerio (Zebrafish) (Brachydanio rerio) 827 multicellular organism development [GO:0007275] GO:0003677; GO:0007275; GO:0008270; GO:0031519; GO:0035102 0 0 0 PF00536; Q8VBX0 CHOYP_ASB13.1.1 m.31541 sp ASB13_MOUSE 44.531 256 141 1 10 265 23 277 1.95E-66 211 ASB13_MOUSE reviewed Ankyrin repeat and SOCS box protein 13 (ASB-13) Asb13 Mus musculus (Mouse) 278 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q8WXS8 CHOYP_ADAMTS3.1.1 m.48480 sp ATS14_HUMAN 26.047 764 431 33 79 777 114 808 1.95E-44 179 ATS14_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-) ADAMTS14 Homo sapiens (Human) 1223 collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199] GO:0004222; GO:0005576; GO:0005578; GO:0008270; GO:0030199; GO:0030574 0 0 0 PF05986;PF01562;PF01421;PF00090; Q90WY6 CHOYP_LOC100374837.1.1 m.26010 sp ADA2C_DANRE 21.429 462 268 14 48 492 41 424 1.95E-08 60.1 ADA2C_DANRE reviewed Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR) adra2c Danio rerio (Zebrafish) (Brachydanio rerio) 432 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; cell-cell signaling [GO:0007267]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of adenylate cyclase activity [GO:0007194]; platelet activation [GO:0030168]; regulation of smooth muscle contraction [GO:0006940]; regulation of vasoconstriction [GO:0019229] GO:0004938; GO:0005886; GO:0005887; GO:0006940; GO:0007186; GO:0007194; GO:0007267; GO:0019229; GO:0030168; GO:0071880 0 0 0 PF00001; Q90XC2 CHOYP_BRAFLDRAFT_124709.1.1 m.21620 sp NEK8_DANRE 38.037 652 352 14 299 910 4 643 1.95E-137 442 NEK8_DANRE reviewed Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) nek8 Danio rerio (Zebrafish) (Brachydanio rerio) 697 cell division [GO:0051301]; determination of heart left/right asymmetry [GO:0061371]; heart looping [GO:0001947]; mitotic nuclear division [GO:0007067]; pronephros development [GO:0048793]; pronephros formation [GO:0072116]; protein phosphorylation [GO:0006468]; renal tubule development [GO:0061326] GO:0001947; GO:0004674; GO:0005524; GO:0005737; GO:0006468; GO:0007067; GO:0046872; GO:0048793; GO:0051301; GO:0061326; GO:0061371; GO:0072116; GO:0072372 0 0 0 PF00069;PF00415; Q91YT2 CHOYP_RN185.1.2 m.44879 sp RN185_MOUSE 72.131 183 49 1 2 182 10 192 1.95E-85 252 RN185_MOUSE reviewed E3 ubiquitin-protein ligase RNF185 (EC 6.3.2.-) (RING finger protein 185) Rnf185 Mus musculus (Mouse) 192 autophagy [GO:0006914]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein autoubiquitination [GO:0051865] GO:0005741; GO:0005783; GO:0006914; GO:0008270; GO:0016021; GO:0016874; GO:0030433; GO:0036503; GO:0036513; GO:0044390; GO:0051865; GO:1904264 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q91YT2 CHOYP_RN185.2.2 m.65170 sp RN185_MOUSE 72.131 183 49 1 2 182 10 192 1.95E-85 252 RN185_MOUSE reviewed E3 ubiquitin-protein ligase RNF185 (EC 6.3.2.-) (RING finger protein 185) Rnf185 Mus musculus (Mouse) 192 autophagy [GO:0006914]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein autoubiquitination [GO:0051865] GO:0005741; GO:0005783; GO:0006914; GO:0008270; GO:0016021; GO:0016874; GO:0030433; GO:0036503; GO:0036513; GO:0044390; GO:0051865; GO:1904264 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q91ZA3 CHOYP_PCCA.1.2 m.3100 sp PCCA_MOUSE 53.636 110 51 0 1 110 615 724 1.95E-33 125 PCCA_MOUSE reviewed "Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)" Pcca Mus musculus (Mouse) 724 0 GO:0004075; GO:0004658; GO:0005524; GO:0005739; GO:0005759; GO:0019899; GO:0046872 PATHWAY: Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. 0 0 PF02785;PF00289;PF00364;PF02786; Q9D1H9 CHOYP_BRAFLDRAFT_88602.2.3 m.20974 sp MFAP4_MOUSE 43.668 229 120 4 48 268 28 255 1.95E-51 172 MFAP4_MOUSE reviewed Microfibril-associated glycoprotein 4 Mfap4 Mus musculus (Mouse) 257 cell adhesion [GO:0007155]; cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; regulation of collagen metabolic process [GO:0010712]; UV protection [GO:0009650] GO:0001527; GO:0005576; GO:0007155; GO:0009650; GO:0010712; GO:0031012; GO:0043206; GO:0048251; GO:0070062; GO:0071493; GO:0071953 0 0 0 PF00147; Q9D8N6 CHOYP_LOC100559879.1.1 m.8598 sp LIN37_MOUSE 38.627 233 132 7 13 234 14 246 1.95E-38 137 LIN37_MOUSE reviewed Protein lin-37 homolog (Antolefinin) (Antolefinine) Lin37 Mus musculus (Mouse) 246 cell cycle [GO:0007049] GO:0007049; GO:0017053 0 0 0 PF15306; Q9ESN6 CHOYP_CBG17454.2.2 m.66258 sp TRIM2_MOUSE 29.747 158 80 5 5 142 23 169 1.95E-12 71.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H3H1 CHOYP_LOC100650049.1.1 m.38649 sp MOD5_HUMAN 42.35 451 219 7 15 459 23 438 1.95E-119 363 MOD5_HUMAN reviewed "tRNA dimethylallyltransferase, mitochondrial (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase) (IPTase)" TRIT1 IPT MOD5 Homo sapiens (Human) 467 mitochondrial tRNA modification [GO:0070900]; tRNA modification [GO:0006400] GO:0003676; GO:0005524; GO:0005739; GO:0005759; GO:0006400; GO:0008270; GO:0052381; GO:0070900 0 0 0 PF01715;PF12171; Q9QYL8 CHOYP_LYPA2.1.1 m.45740 sp LYPA2_RAT 51.528 229 107 3 42 267 2 229 1.95E-77 237 LYPA2_RAT reviewed Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase 2) (Lysophospholipase II) (LPL-II) (LysoPLA II) Lypla2 Rattus norvegicus (Rat) 231 fatty acid metabolic process [GO:0006631]; protein depalmitoylation [GO:0002084] GO:0002084; GO:0005737; GO:0006631; GO:0008474; GO:0052689; GO:0070062 0 0 0 PF02230; Q9UJG1 CHOYP_UBP20.1.2 m.2796 sp MSPD1_HUMAN 53.11 209 93 2 7 215 8 211 1.95E-71 219 MSPD1_HUMAN reviewed Motile sperm domain-containing protein 1 MOSPD1 Homo sapiens (Human) 213 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000122; GO:0005634; GO:0005737; GO:0016021; GO:0045944; GO:0048471 0 0 0 PF00635; Q9Y6R7 CHOYP_LOC580187.2.4 m.37211 sp FCGBP_HUMAN 25 296 204 9 94 381 135 420 1.95E-16 85.1 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A4IF63 CHOYP_BRAFLDRAFT_69778.1.1 m.8074 sp TRIM2_BOVIN 33.019 106 67 3 41 143 627 731 1.96E-09 58.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7YY35 CHOYP_IFRX2.9.10 m.47880 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 1.96E-19 98.6 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; B1WC97 CHOYP_LOC100377510.4.4 m.63603 sp KCTD7_RAT 46.939 98 46 2 268 365 53 144 1.96E-18 87.8 KCTD7_RAT reviewed BTB/POZ domain-containing protein KCTD7 Kctd7 Rattus norvegicus (Rat) 289 protein homooligomerization [GO:0051260] GO:0005829; GO:0005886; GO:0051260 0 0 0 PF02214; D2GXS7 CHOYP_BRAFLDRAFT_241726.10.22 m.32634 sp TRIM2_AILME 22.656 256 184 7 24 268 492 744 1.96E-07 55.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_71596.1.1 m.32856 sp TRIM2_AILME 25.676 222 152 5 5 215 497 716 1.96E-08 57.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_88223.12.22 m.46964 sp TRIM2_AILME 24.057 212 138 7 378 576 540 741 1.96E-08 60.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_DSCAM.2.3 m.54042 sp HMCN1_MOUSE 27.919 394 235 19 85 467 530 885 1.96E-15 85.5 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O01761 CHOYP_ISCW_ISCW022096.2.2 m.47544 sp UNC89_CAEEL 28.477 302 171 17 57 343 4310 4581 1.96E-06 53.5 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O07552 CHOYP_LOC100181607.1.2 m.36709 sp NHAX_BACSU 33.333 81 54 0 113 193 86 166 1.96E-08 54.7 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O17450 CHOYP_BRAFLDRAFT_125880.3.3 m.26918 sp PE48_CHRBE 31.915 94 62 2 63 155 43 135 1.96E-07 53.1 PE48_CHRBE reviewed Peritrophin-48 0 Chrysomya bezziana (Old world screw-worm fly) 379 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607; O57383 CHOYP_DPOLB.1.1 m.15375 sp DPOLB_XENLA 66.469 337 109 2 1 337 1 333 1.96E-162 459 DPOLB_XENLA reviewed DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) polb Xenopus laevis (African clawed frog) 334 base-excision repair [GO:0006284]; cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0005634; GO:0005737; GO:0006260; GO:0006284; GO:0006974; GO:0016829; GO:0046872 0 0 cd00141; PF14792;PF14791;PF10391;PF14716; O88280 CHOYP_BRAFLDRAFT_89744.1.1 m.29497 sp SLIT3_RAT 25.869 259 171 8 42 295 235 477 1.96E-12 72.8 SLIT3_RAT reviewed Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) Slit3 Megf5 Rattus norvegicus (Rat) 1523 axon extension involved in axon guidance [GO:0048846]; brain development [GO:0007420]; regulation of axonogenesis [GO:0050770]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510] GO:0005509; GO:0005578; GO:0005615; GO:0007420; GO:0008201; GO:0016020; GO:0021510; GO:0035385; GO:0048495; GO:0048846; GO:0050770 0 0 0 PF00008;PF02210;PF13855;PF01463;PF01462; O94813 CHOYP_LOC100908348.1.1 m.44598 sp SLIT2_HUMAN 22.319 345 198 11 142 451 58 367 1.96E-11 71.6 SLIT2_HUMAN reviewed Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) 1529 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; response to cortisol [GO:0051414]; response to nutrient levels [GO:0031667]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510]; ureteric bud development [GO:0001657] GO:0001657; GO:0001933; GO:0002042; GO:0002689; GO:0005095; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005737; GO:0005886; GO:0007411; GO:0008045; GO:0008201; GO:0009986; GO:0010593; GO:0010596; GO:0014912; GO:0016020; GO:0021510; GO:0021836; GO:0021972; GO:0030308; GO:0030336; GO:0030837; GO:0031290; GO:0031667; GO:0032870; GO:0035385; GO:0042802; GO:0042803; GO:0043065; GO:0043116; GO:0043237; GO:0043394; GO:0043395; GO:0048495; GO:0048754; GO:0048846; GO:0050728; GO:0050772; GO:0050919; GO:0050929; GO:0051058; GO:0051414; GO:0061364; GO:0070062; GO:0070100; GO:0071504; GO:0071672; GO:0071676; GO:0090024; GO:0090027; GO:0090260; GO:0090288 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P00548 CHOYP_KPYK.4.4 m.48514 sp KPYM_CHICK 62.376 202 72 1 18 215 8 209 1.96E-84 263 KPYM_CHICK reviewed Pyruvate kinase PKM (EC 2.7.1.40) PKM Gallus gallus (Chicken) 530 glycolytic process [GO:0006096] GO:0000287; GO:0004743; GO:0005524; GO:0005829; GO:0006096; GO:0016301; GO:0030955 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. 0 0 PF00224;PF02887; P13993 CHOYP_CG15306.1.1 m.12097 sp PRP2_SOYBN 31.148 122 79 2 290 411 79 195 1.96E-13 73.9 PRP2_SOYBN reviewed Repetitive proline-rich cell wall protein 2 PRP2 RPRP3 Glycine max (Soybean) (Glycine hispida) 230 multicellular organism development [GO:0007275] GO:0005199; GO:0005576; GO:0005618; GO:0007275 0 0 0 PF02095; P16157 CHOYP_TVAG_123950.31.31 m.66810 sp ANK1_HUMAN 30.418 263 167 1 90 352 335 581 1.96E-28 120 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20273 CHOYP_DSCAM.1.3 m.25974 sp CD22_HUMAN 21.206 481 331 16 103 572 223 666 1.96E-14 81.3 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P34416 CHOYP_LASP.1.1 m.51339 sp LASP1_CAEEL 66.667 141 45 1 1 139 1 141 1.96E-62 199 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P35400 CHOYP_NOL9.1.2 m.16472 sp GRM7_RAT 29.536 474 297 17 503 951 40 501 1.96E-40 166 GRM7_RAT reviewed Metabotropic glutamate receptor 7 (mGluR7) Grm7 Gprc1g Mglur7 Rattus norvegicus (Rat) 915 "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [GO:0007196]; learning or memory [GO:0007611]; negative regulation of glutamate secretion [GO:0014050]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of smell [GO:0007608]" GO:0001640; GO:0001642; GO:0005246; GO:0005516; GO:0005791; GO:0005794; GO:0005887; GO:0007196; GO:0007608; GO:0007611; GO:0009986; GO:0014050; GO:0016020; GO:0016595; GO:0030165; GO:0030424; GO:0030425; GO:0032279; GO:0042734; GO:0042803; GO:0043025; GO:0043195; GO:0043198; GO:0043234; GO:0043679; GO:0045202; GO:0045211; GO:0048306; GO:0048786; GO:0051966 0 0 0 PF00003;PF01094;PF07562; P41241 CHOYP_BRAFLDRAFT_81321.3.10 m.34305 sp CSK_MOUSE 28.125 288 158 8 680 957 195 443 1.96E-18 92.8 CSK_MOUSE reviewed Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase MPK-2) (p50CSK) Csk Mus musculus (Mouse) 450 adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system development [GO:0007417]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of kinase activity [GO:0033673]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of MAP kinase activity [GO:0043406]; protein phosphorylation [GO:0006468]; regulation of cytokine production [GO:0001817]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of T cell activation [GO:0050863]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001817; GO:0002250; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005737; GO:0005886; GO:0005911; GO:0006468; GO:0007169; GO:0007417; GO:0007420; GO:0008285; GO:0010989; GO:0016477; GO:0016740; GO:0030154; GO:0031234; GO:0032715; GO:0033673; GO:0034236; GO:0034332; GO:0035556; GO:0038083; GO:0042802; GO:0042997; GO:0043406; GO:0045087; GO:0045121; GO:0045779; GO:0046872; GO:0048709; GO:0050765; GO:0050863; GO:0060368; GO:0070062; GO:0070373; GO:0071375 0 0 0 PF07714;PF00017;PF00018; Q00PJ1 CHOYP_TVAG_123950.7.31 m.32880 sp CTTB2_ATEAB 42.574 101 58 0 1 101 731 831 1.96E-19 85.1 CTTB2_ATEAB reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) 1654 0 GO:0005938; GO:0043197 0 0 0 PF12796;PF09727; Q01177 CHOYP_PLMN.2.11 m.22222 sp PLMN_RAT 40.244 492 203 21 672 1103 100 560 1.96E-88 306 PLMN_RAT reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Rattus norvegicus (Rat) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; proteolysis involved in cellular protein catabolic process [GO:0051603]; tissue regeneration [GO:0042246]; tissue remodeling [GO:0048771]; trophoblast giant cell differentiation [GO:0060707] GO:0004175; GO:0004252; GO:0005576; GO:0005886; GO:0007596; GO:0019897; GO:0042246; GO:0042730; GO:0043231; GO:0045445; GO:0046716; GO:0048771; GO:0051603; GO:0060707; GO:0060716; GO:0071674 0 0 cd00190; PF00051;PF00024;PF00089; Q03049 CHOYP_LOC100376187.1.2 m.22540 sp YD541_YEAST 36.972 284 156 8 10 273 5 285 1.96E-50 177 YD541_YEAST reviewed Putative uncharacterized oxidoreductase YDR541C (EC 1.1.1.-) YDR541C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 344 response to furfural [GO:1901426] GO:0033721; GO:0050662; GO:1901426 0 0 0 PF01370; Q07008 CHOYP_DNER.1.1 m.28378 sp NOTC1_RAT 40.179 112 66 1 142 252 494 605 1.96E-20 98.2 NOTC1_RAT reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] Notch1 Rattus norvegicus (Rat) 2531 "aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; auditory receptor cell fate commitment [GO:0009912]; axonogenesis [GO:0007409]; brain development [GO:0007420]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac vascular smooth muscle cell development [GO:0060948]; cell differentiation in spinal cord [GO:0021515]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium morphogenesis [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; organ regeneration [GO:0031100]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral transcription [GO:0050434]; prostate gland epithelium morphogenesis [GO:0060740]; pulmonary valve morphogenesis [GO:0003184]; regulation of cardioblast proliferation [GO:0003264]; regulation of cell proliferation [GO:0042127]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; tissue regeneration [GO:0042246]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0001047; GO:0001190; GO:0001669; GO:0001701; GO:0001708; GO:0001726; GO:0001889; GO:0001947; GO:0002040; GO:0002052; GO:0002193; GO:0002437; GO:0003160; GO:0003162; GO:0003169; GO:0003180; GO:0003184; GO:0003192; GO:0003198; GO:0003213; GO:0003214; GO:0003219; GO:0003222; GO:0003241; GO:0003256; GO:0003264; GO:0003270; GO:0003273; GO:0003344; GO:0003700; GO:0004857; GO:0004872; GO:0005509; GO:0005634; GO:0005783; GO:0005794; GO:0005856; GO:0005886; GO:0005912; GO:0006959; GO:0007219; GO:0007221; GO:0007283; GO:0007386; GO:0007409; GO:0007420; GO:0007440; GO:0007492; GO:0008285; GO:0009912; GO:0009986; GO:0010718; GO:0010812; GO:0010832; GO:0014807; GO:0016021; GO:0016324; GO:0019899; GO:0021515; GO:0021915; GO:0030027; GO:0030216; GO:0030324; GO:0030335; GO:0030513; GO:0030514; GO:0030900; GO:0031069; GO:0031100; GO:0031490; GO:0031960; GO:0032495; GO:0032496; GO:0035116; GO:0035148; GO:0035914; GO:0035924; GO:0042127; GO:0042246; GO:0043065; GO:0043086; GO:0043235; GO:0043565; GO:0045070; GO:0045603; GO:0045608; GO:0045618; GO:0045662; GO:0045665; GO:0045668; GO:0045687; GO:0045747; GO:0045893; GO:0045944; GO:0045955; GO:0046427; GO:0046533; GO:0048103; GO:0048708; GO:0048709; GO:0048711; GO:0048715; GO:0048754; GO:0050434; GO:0050679; GO:0050768; GO:0060038; GO:0060045; GO:0060253; GO:0060271; GO:0060412; GO:0060528; GO:0060740; GO:0060768; GO:0060842; GO:0060843; GO:0060948; GO:0060956; GO:0060979; GO:0060982; GO:0061314; GO:0061419; GO:0070986; GO:0071372; GO:0072017; GO:0072044; GO:0072144; GO:0072602; GO:0090051; GO:0090090; GO:0097150; GO:1901201; GO:1902263; GO:2000737; GO:2000811; GO:2000974; GO:2001027 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; Q0VAA2 CHOYP_BRAFLDRAFT_124994.1.1 m.55760 sp LR74A_HUMAN 30.37 405 265 6 227 618 72 472 1.96E-47 177 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q1LWC2 CHOYP_T106B.1.1 m.65174 sp T106B_DANRE 33.61 241 143 5 51 288 30 256 1.96E-34 128 T106B_DANRE reviewed Transmembrane protein 106B tmem106b ch211-134n17.2 ch211-195l15.2 zgc:114147 Danio rerio (Zebrafish) (Brachydanio rerio) 267 dendrite morphogenesis [GO:0048813]; lysosome localization [GO:0032418]; transport [GO:0006810] GO:0005765; GO:0006810; GO:0016020; GO:0016021; GO:0031902; GO:0032418; GO:0048813 0 0 0 PF07092; Q1LZ79 CHOYP_GEMIN8.1.1 m.8895 sp GEMI8_BOVIN 29.614 233 141 7 165 388 10 228 1.96E-24 103 GEMI8_BOVIN reviewed Gem-associated protein 8 (Gemin-8) GEMIN8 Bos taurus (Bovine) 234 spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0005634; GO:0005829; GO:0032797; GO:0034719; GO:0097504 0 0 0 0 Q2PC93 CHOYP_LOC100497129.8.8 m.64258 sp SSPO_CHICK 40.063 317 168 10 1 307 1283 1587 1.96E-52 209 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q502D1 CHOYP_GLOD5.1.1 m.25831 sp GLOD5_DANRE 64.706 136 48 0 22 157 28 163 1.96E-61 189 GLOD5_DANRE reviewed Glyoxalase domain-containing protein 5 glod5 zgc:112315 Danio rerio (Zebrafish) (Brachydanio rerio) 163 0 0 0 0 0 PF00903; Q5BKX0 CHOYP_CALRL.2.3 m.42464 sp TM248_DANRE 30.097 309 193 6 9 304 9 307 1.96E-47 164 TM248_DANRE reviewed Transmembrane protein 248 tmem248 zgc:103561 Danio rerio (Zebrafish) (Brachydanio rerio) 315 0 GO:0016021 0 0 0 0 Q5FWY5 CHOYP_LOC658248.1.1 m.11054 sp AIP_RAT 45.455 330 177 3 3 330 1 329 1.96E-108 322 AIP_RAT reviewed AH receptor-interacting protein (AIP) (Aryl-hydrocarbon receptor-interacting protein) (Immunophilin XAP2) Aip Xap2 Rattus norvegicus (Rat) 330 negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; protein maturation by protein folding [GO:0022417]; protein targeting to mitochondrion [GO:0006626]; regulation of protein kinase A signaling [GO:0010738]; xenobiotic metabolic process [GO:0006805] GO:0003712; GO:0005654; GO:0005829; GO:0005886; GO:0006626; GO:0006805; GO:0010738; GO:0022417; GO:0034751; GO:0051082; GO:0051344 0 0 0 PF00254; Q5RDU7 CHOYP_LOC100372803.1.2 m.18615 sp YPEL5_PONAB 88.235 119 14 0 1 119 1 119 1.96E-75 222 YPEL5_PONAB reviewed Protein yippee-like 5 YPEL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 121 0 GO:0046872 0 0 0 PF03226; Q5RDU7 CHOYP_LOC100372803.2.2 m.61793 sp YPEL5_PONAB 88.235 119 14 0 1 119 1 119 1.96E-75 222 YPEL5_PONAB reviewed Protein yippee-like 5 YPEL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 121 0 GO:0046872 0 0 0 PF03226; Q5RDU7 CHOYP_LOC100875390.1.1 m.24781 sp YPEL5_PONAB 88.235 119 14 0 1 119 1 119 1.96E-75 222 YPEL5_PONAB reviewed Protein yippee-like 5 YPEL5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 121 0 GO:0046872 0 0 0 PF03226; Q5UQ35 CHOYP_LOC100378011.1.2 m.21021 sp YR811_MIMIV 29.317 249 128 12 19 245 3 225 1.96E-14 77.8 YR811_MIMIV reviewed Putative ariadne-like RING finger protein R811 MIMI_R811 Acanthamoeba polyphaga mimivirus (APMV) 990 0 GO:0008270 0 0 0 PF01485; Q5XI63 CHOYP_ATK5.1.1 m.15234 sp KIFC1_RAT 41.775 383 169 12 283 624 316 685 1.96E-75 258 KIFC1_RAT reviewed Kinesin-like protein KIFC1 (Kinesin-related protein 1) Kifc1 Krp1 Rattus norvegicus (Rat) 693 cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; spermatogenesis [GO:0007283] GO:0003777; GO:0005524; GO:0005634; GO:0005769; GO:0005815; GO:0005819; GO:0005871; GO:0005874; GO:0007018; GO:0007080; GO:0007283; GO:0016020; GO:0016887; GO:0051301; GO:0090307 0 0 0 PF00225; Q6R5N8 CHOYP_TLR2.1.7 m.25660 sp TLR13_MOUSE 24.744 683 400 26 53 718 396 981 1.96E-24 113 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q70PU1 CHOYP_LOC100379013.2.3 m.45032 sp PGSC2_DROSI 45.122 82 45 0 150 231 21 102 1.96E-21 90.9 PGSC2_DROSI reviewed Peptidoglycan-recognition protein SC2 (EC 3.5.1.28) PGRP-SC2 GD10595 Drosophila simulans (Fruit fly) 184 innate immune response [GO:0045087]; peptidoglycan catabolic process [GO:0009253] GO:0005576; GO:0008270; GO:0008745; GO:0009253; GO:0045087 0 0 cd06583; PF01510; Q80T91 CHOYP_MEG10.73.91 m.56481 sp MEG11_MOUSE 35.89 326 183 16 134 456 304 606 1.96E-38 154 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q868T3 CHOYP_LOC100574733.1.1 m.62362 sp CCAPR_DROME 42.614 352 161 7 22 360 96 419 1.96E-87 278 CCAPR_DROME reviewed Cardioacceleratory peptide receptor (Crustacean cardioactive peptide receptor) CCAP-R CcapR CG33344 Drosophila melanogaster (Fruit fly) 495 "ecdysis, chitin-based cuticle [GO:0018990]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]" GO:0005000; GO:0005887; GO:0007186; GO:0007218; GO:0008188; GO:0016021; GO:0018990 0 0 0 PF00001; Q86Y13 CHOYP_BM1_12515.1.7 m.4154 sp DZIP3_HUMAN 31.868 91 60 1 62 150 451 541 1.96E-08 61.6 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8IW92 CHOYP_GLBL2.1.2 m.8379 sp GLBL2_HUMAN 42.122 622 323 16 58 675 39 627 1.96E-144 437 GLBL2_HUMAN reviewed Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) GLB1L2 MSTP014 UNQ210/PRO236 Homo sapiens (Human) 636 carbohydrate metabolic process [GO:0005975] GO:0004565; GO:0005576; GO:0005773; GO:0005975 0 0 0 PF01301; Q8K0U4 CHOYP_LOC100372773.2.9 m.31677 sp HS12A_MOUSE 21.053 475 301 20 6 415 57 522 1.96E-13 76.3 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8TCB0 CHOYP_BRAFLDRAFT_91636.3.11 m.41241 sp IFI44_HUMAN 27.655 452 272 13 14 455 17 423 1.96E-49 177 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q8WUB8 CHOYP_PHF10.1.1 m.6981 sp PHF10_HUMAN 47.863 468 195 10 348 769 34 498 1.96E-132 407 PHF10_HUMAN reviewed PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135) PHF10 BAF45A Homo sapiens (Human) 498 "nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007399; GO:0008270; GO:0071564 0 0 0 PF00628; Q96MU7 CHOYP_LOC586835.1.1 m.9967 sp YTDC1_HUMAN 52.692 260 113 3 194 450 260 512 1.96E-79 266 YTDC1_HUMAN reviewed YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) YTHDC1 KIAA1966 YT521 Homo sapiens (Human) 727 "mRNA splice site selection [GO:0006376]; regulation of mRNA splicing, via spliceosome [GO:0048024]" GO:0003723; GO:0005634; GO:0006376; GO:0016607; GO:0044822; GO:0048024; GO:1990247 0 0 0 PF04146; Q96RJ6 CHOYP_LOC100371559.1.1 m.10128 sp FER3L_HUMAN 67.606 71 23 0 103 173 86 156 1.96E-27 105 FER3L_HUMAN reviewed Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist) FERD3L BHLHA31 NATO3 NTWIST Homo sapiens (Human) 166 "cell development [GO:0048468]; floor plate development [GO:0033504]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of neurogenesis [GO:0050767]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0001227; GO:0005634; GO:0006351; GO:0033504; GO:0045892; GO:0048468; GO:0050767 0 0 0 PF00010; Q9BXI9 CHOYP_BRAFLDRAFT_69134.5.13 m.20980 sp C1QT6_HUMAN 25.806 124 84 2 42 165 113 228 1.96E-08 55.5 C1QT6_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 6 C1QTNF6 CTRP6 UNQ581/PRO1151 Homo sapiens (Human) 259 protein heterotrimerization [GO:0070208] GO:0005581; GO:0005615; GO:0070208 0 0 0 PF00386;PF01391; Q9CSH3 CHOYP_contig_039310 m.44525 sp RRP44_MOUSE 49.333 150 72 2 1 146 806 955 1.96E-40 147 RRP44_MOUSE reviewed Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44) Dis3 Kiaa1008 Rrp44 Mus musculus (Mouse) 958 CUT catabolic process [GO:0071034]; mRNA catabolic process [GO:0006402]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364] GO:0000175; GO:0000176; GO:0000177; GO:0003723; GO:0004519; GO:0005085; GO:0005654; GO:0005730; GO:0006364; GO:0006402; GO:0016020; GO:0016075; GO:0071034 0 0 0 PF13638; Q9H2Y9 CHOYP_MYSP.9.9 m.49627 sp SO5A1_HUMAN 37.967 669 370 11 86 721 128 784 1.96E-153 471 SO5A1_HUMAN reviewed Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15) SLCO5A1 OATP5A1 SLC21A15 Homo sapiens (Human) 848 sodium-independent organic anion transport [GO:0043252] GO:0005887; GO:0015347; GO:0043252 0 0 cd06174; PF07648;PF03137; Q9JMB1 CHOYP_BRAFLDRAFT_120588.1.1 m.22993 sp THEG_MOUSE 27.049 244 145 6 31 271 162 375 1.96E-12 70.1 THEG_MOUSE reviewed Testicular haploid expressed gene protein Theg Mus musculus (Mouse) 375 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0007275; GO:0007283; GO:0030154 0 0 0 PF14912; Q9NRZ5 CHOYP_LOC100876057.1.1 m.1636 sp PLCD_HUMAN 39.73 370 220 2 5 373 8 375 1.96E-97 297 PLCD_HUMAN reviewed 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 4) (1-AGP acyltransferase 4) (1-AGPAT 4) (Lysophosphatidic acid acyltransferase delta) (LPAAT-delta) AGPAT4 UNQ499/PRO1016 Homo sapiens (Human) 378 CDP-diacylglycerol biosynthetic process [GO:0016024]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; triglyceride biosynthetic process [GO:0019432] GO:0003841; GO:0005789; GO:0006654; GO:0008654; GO:0016021; GO:0016024; GO:0019432 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. 0 0 PF16076;PF01553; Q9NS23 CHOYP_ISCW_ISCW007158.1.2 m.23865 sp RASF1_HUMAN 33.108 296 154 7 358 652 86 338 1.96E-41 157 RASF1_HUMAN reviewed Ras association domain-containing protein 1 RASSF1 RDA32 Homo sapiens (Human) 344 cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of cell cycle arrest [GO:0071157]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; Ras protein signal transduction [GO:0007265]; regulation of microtubule cytoskeleton organization [GO:0070507] GO:0000922; GO:0005634; GO:0005737; GO:0005815; GO:0005874; GO:0005886; GO:0006974; GO:0007050; GO:0007265; GO:0008270; GO:0015630; GO:0031398; GO:0042802; GO:0047485; GO:0050821; GO:0070507; GO:0071157 0 0 0 PF16517;PF00788; Q9NX05 CHOYP_LOC100877311.1.1 m.25123 sp F120C_HUMAN 37.124 897 411 26 46 834 118 969 1.96E-169 528 F120C_HUMAN reviewed Constitutive coactivator of PPAR-gamma-like protein 2 (Protein FAM120C) (Tumor antigen BJ-HCC-21) FAM120C CXorf17 Homo sapiens (Human) 1096 0 GO:0005634; GO:0044822 0 0 0 0 Q9PTG8 CHOYP_TACC3.1.3 m.8366 sp TACC3_XENLA 31.22 410 219 10 687 1090 577 929 1.96E-37 155 TACC3_XENLA reviewed Transforming acidic coiled-coil-containing protein 3 (Cytoplasmic polyadenylation element-binding protein-associated factor Maskin) (CPEB-associated factor Maskin) tacc3 maskin Xenopus laevis (African clawed frog) 931 negative regulation of translation [GO:0017148] GO:0005737; GO:0017148; GO:0031369; GO:0043234 0 0 0 PF05010; Q9UPI3 CHOYP_FLVC2.1.1 m.5694 sp FLVC2_HUMAN 58.039 255 104 2 1 253 250 503 1.96E-92 287 FLVC2_HUMAN reviewed Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT) FLVCR2 C14orf58 Homo sapiens (Human) 526 transmembrane transport [GO:0055085] GO:0005886; GO:0015232; GO:0016021; GO:0020037; GO:0055085 0 0 cd06174; PF07690; Q9VI93 CHOYP_AGAP_AGAP002083.1.1 m.38334 sp RN_DROME 71.264 174 49 1 136 309 486 658 1.96E-84 281 RN_DROME reviewed Zinc finger protein rotund (Zinc finger protein roughened eye) rn roe CG32466 Drosophila melanogaster (Fruit fly) 946 "cell fate specification [GO:0001708]; chaeta development [GO:0022416]; compound eye development [GO:0048749]; imaginal disc-derived leg morphogenesis [GO:0007480]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; sensory perception of pain [GO:0019233]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001708; GO:0003676; GO:0003705; GO:0005634; GO:0006351; GO:0007480; GO:0019233; GO:0022416; GO:0045892; GO:0046872; GO:0048749 0 0 0 PF00096; Q9W141 CHOYP_ISCW_ISCW016254.4.5 m.50369 sp ATPK_DROME 40.909 66 39 0 10 75 3 68 1.96E-13 63.9 ATPK_DROME reviewed "Putative ATP synthase subunit f, mitochondrial" CG4692 Drosophila melanogaster (Fruit fly) 107 ATP biosynthetic process [GO:0006754]; lateral inhibition [GO:0046331]; proton transport [GO:0015992] GO:0005739; GO:0005811; GO:0006754; GO:0015992; GO:0031966; GO:0045263; GO:0046331 0 0 0 PF10206; Q9X6U2 CHOYP_RSC1572.1.1 m.40800 sp BDHA_CUPNH 37.634 93 58 0 12 104 136 228 1.96E-12 64.3 BDHA_CUPNH reviewed D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) hbdH1 H16_A1334 Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 258 0 GO:0003858 0 0 0 PF00106; Q9Y3E1 CHOYP_PSIP1.1.1 m.61157 sp HDGR3_HUMAN 56.716 134 52 2 8 136 9 141 1.96E-42 157 HDGR3_HUMAN reviewed Hepatoma-derived growth factor-related protein 3 (HRP-3) (Hepatoma-derived growth factor 2) (HDGF-2) HDGFRP3 HDGF2 CGI-142 Homo sapiens (Human) 203 cell proliferation [GO:0008283]; microtubule polymerization [GO:0046785]; negative regulation of microtubule depolymerization [GO:0007026]; neuron projection development [GO:0031175] GO:0005634; GO:0005654; GO:0005829; GO:0007026; GO:0008017; GO:0008283; GO:0015631; GO:0031175; GO:0046785 0 0 0 PF00855; A4IIK1 CHOYP_BRAFLDRAFT_65562.1.1 m.14267 sp MFHA1_XENTR 24.595 370 225 11 18 340 612 974 1.97E-24 111 MFHA1_XENTR reviewed Malignant fibrous histiocytoma-amplified sequence 1 homolog mfhas1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 997 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF16095;PF13855;PF08477; B0WYR6 CHOYP_LOC100368844.1.1 m.45290 sp WDY_CULQU 23.126 934 575 31 153 992 6 890 1.97E-61 232 WDY_CULQU reviewed WD repeat-containing protein on Y chromosome (WD40 Y) WDY CPIJ012294 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) 1033 0 0 0 0 0 PF00400; B6D5P6 CHOYP_LOC100672555.1.1 m.15827 sp DAAF1_PERCA 48.018 454 179 10 109 528 80 510 1.97E-123 382 DAAF1_PERCA reviewed "Dynein assembly factor 1, axonemal (Leucine-rich repeat-containing protein 50)" Dnaaf1 Lrrc50 Peromyscus californicus (California mouse) 622 cilium morphogenesis [GO:0060271]; motile cilium assembly [GO:0044458] GO:0005930; GO:0044458; GO:0045502; GO:0060271 0 0 0 0 D3YXG0 CHOYP_BRAFLDRAFT_66209.2.3 m.28562 sp HMCN1_MOUSE 47.716 197 96 2 499 695 4583 4772 1.97E-55 209 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D4A2Z2 CHOYP_LOC100661914.1.1 m.39820 sp EPPI_RAT 38.356 146 69 5 5 150 7 131 1.97E-22 89.7 EPPI_RAT reviewed Eppin (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1) Eppin Spinlw1 Rattus norvegicus (Rat) 134 defense response to bacterium [GO:0042742]; negative regulation of peptidase activity [GO:0010466] GO:0001669; GO:0004867; GO:0005576; GO:0010466; GO:0042742 0 0 0 PF00014;PF00095; O00748 CHOYP_CES2B.1.1 m.44225 sp EST2_HUMAN 39.041 146 72 4 56 187 17 159 1.97E-21 94 EST2_HUMAN reviewed Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) CES2 ICE Homo sapiens (Human) 559 catabolic process [GO:0009056]; xenobiotic metabolic process [GO:0006805] GO:0005615; GO:0005783; GO:0005788; GO:0006805; GO:0009056; GO:0047374; GO:0052689 0 0 0 PF00135; O01812 CHOYP_FABP6.1.2 m.49858 sp FABP6_CAEEL 35.766 137 76 4 6 137 1 130 1.97E-17 76.3 FABP6_CAEEL reviewed Fatty acid-binding protein homolog 6 lbp-6 W02D3.5 Caenorhabditis elegans 135 0 GO:0005215; GO:0008289 0 0 0 PF00061; O14522 CHOYP_LOC578045.2.5 m.41279 sp PTPRT_HUMAN 30.486 597 367 15 77 655 874 1440 1.97E-68 246 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O16011 CHOYP_DYAK_GE11656.1.2 m.34706 sp MBL_DROME 51.196 209 76 9 1 208 1 184 1.97E-53 179 MBL_DROME reviewed Protein muscleblind (Protein mindmelt) mbl mm CG33197 Drosophila melanogaster (Fruit fly) 297 "apoptotic process [GO:0006915]; compound eye photoreceptor cell differentiation [GO:0001751]; embryo development [GO:0009790]; eye development [GO:0001654]; imaginal disc-derived wing morphogenesis [GO:0007476]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; peripheral nervous system development [GO:0007422]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of female receptivity [GO:0045924]; regulation of gene expression [GO:0010468]; response to stimulus [GO:0050896]; rhabdomere development [GO:0042052]; somatic muscle development [GO:0007525]; visual perception [GO:0007601]" GO:0000381; GO:0001654; GO:0001751; GO:0003676; GO:0003677; GO:0005634; GO:0005737; GO:0006915; GO:0007422; GO:0007476; GO:0007517; GO:0007525; GO:0007601; GO:0009790; GO:0010468; GO:0030018; GO:0031673; GO:0042052; GO:0045924; GO:0046716; GO:0046872; GO:0048471; GO:0050896 0 0 0 0 O35737 CHOYP_BRAFLDRAFT_136434.1.1 m.33244 sp HNRH1_MOUSE 64.571 175 61 1 27 201 9 182 1.97E-72 229 HNRH1_MOUSE reviewed "Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]" Hnrnph1 Hnrph Hnrph1 Mus musculus (Mouse) 449 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005654; GO:0005737; GO:0006397; GO:0008380; GO:0016020; GO:0043484; GO:0044822; GO:0071013 0 0 0 PF00076;PF08080; O46160 CHOYP_RN45S.1.5 m.2402 sp RL14_LUMRU 58.947 95 38 1 1 94 50 144 1.97E-29 105 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O75179 CHOYP_LOC100639010.4.9 m.41544 sp ANR17_HUMAN 42.69 171 91 5 1 166 549 717 1.97E-26 107 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P04323 CHOYP_LOC587827.2.4 m.17113 sp POL3_DROME 41.627 418 230 6 5 414 212 623 1.97E-101 327 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P13944 CHOYP_LOC100636433.4.4 m.29807 sp COCA1_CHICK 30.702 228 141 5 77 290 392 616 1.97E-24 113 COCA1_CHICK reviewed Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) 3124 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00041;PF00092; P14730 CHOYP_WAP1.2.4 m.39676 sp WFD18_RAT 42.254 71 35 1 12 76 4 74 1.97E-08 53.1 WFD18_RAT reviewed WAP four-disulfide core domain protein 18 (Extracellular peptidase inhibitor) (Protein WDNM1) (Fragment) Wfdc18 Expi Wdnm1 Rattus norvegicus (Rat) 74 0 GO:0005576; GO:0030414 0 0 0 PF00095; P19039 CHOYP_EF1A2.1.3 m.30026 sp EF1A_APIME 72 75 21 0 7 81 361 435 1.97E-32 120 EF1A_APIME reviewed Elongation factor 1-alpha (EF-1-alpha) 0 Apis mellifera (Honeybee) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; P21613 CHOYP_KHC1.2.2 m.63809 sp KINH_DORPE 73.709 213 54 2 202 414 715 925 1.97E-89 294 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P26009 CHOYP_ITA8.3.3 m.65201 sp ITA8_CHICK 34.398 1096 599 37 51 1103 22 1040 1.97E-163 514 ITA8_CHICK reviewed Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Gallus gallus (Chicken) 1044 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; integrin-mediated signaling pathway [GO:0007229]; nervous system development [GO:0007399] GO:0007155; GO:0007229; GO:0007399; GO:0008305; GO:0030154; GO:0046872 0 0 0 PF01839;PF00357;PF08441; P28828 CHOYP_PTPRM.2.15 m.18796 sp PTPRM_MOUSE 36.705 613 358 15 780 1380 858 1452 1.97E-108 380 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P35224 CHOYP_LOC100533383.2.2 m.18660 sp CTNB_URECA 80.455 220 41 2 1 220 305 522 1.97E-116 356 CTNB_URECA reviewed Catenin beta (Beta-catenin) 0 Urechis caupo (Innkeeper worm) (Spoonworm) 818 adherens junction assembly [GO:0034333]; cell adhesion [GO:0007155] GO:0004871; GO:0005737; GO:0005856; GO:0007155; GO:0034333 0 0 0 PF00514; P42700 CHOYP_LOC100634688.4.6 m.39511 sp RO60_XENLA 38.028 355 146 6 3 357 253 533 1.97E-57 198 RO60_XENLA reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) 538 cell projection organization [GO:0030030] GO:0005737; GO:0030030; GO:0030529; GO:0034336; GO:0046872 0 0 0 PF05731; P43143 CHOYP_BRAFLDRAFT_174537.1.2 m.24855 sp ACHA6_RAT 27.333 300 208 5 7 300 34 329 1.97E-30 124 ACHA6_RAT reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) 493 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of dopamine secretion [GO:0033603]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0033603; GO:0035094; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; P90689 CHOYP_LOC100890099.1.1 m.11507 sp ACT_BRUMA 99.01 101 1 0 1 101 1 101 1.97E-70 217 ACT_BRUMA reviewed Actin 0 Brugia malayi (Filarial nematode worm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q02357 CHOYP_TVAG_168010.41.45 m.61145 sp ANK1_MOUSE 32.011 353 193 3 766 1089 74 408 1.97E-44 179 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q09225 CHOYP_BRAFLDRAFT_66621.2.4 m.12601 sp NRF6_CAEEL 29.51 715 373 22 88 726 143 802 1.97E-80 277 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q0VCR6 CHOYP_LOC100374932.1.1 m.17375 sp TMM68_BOVIN 50 290 140 3 34 320 36 323 1.97E-103 309 TMM68_BOVIN reviewed Transmembrane protein 68 TMEM68 Bos taurus (Bovine) 334 metabolic process [GO:0008152] GO:0008152; GO:0016021; GO:0016746 0 0 0 PF01553; Q13114 CHOYP_TRAF3.2.4 m.28049 sp TRAF3_HUMAN 39.123 570 314 10 53 607 14 565 1.97E-139 420 TRAF3_HUMAN reviewed TNF receptor-associated factor 3 (EC 6.3.2.-) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) TRAF3 CAP1 CRAF1 Homo sapiens (Human) 568 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon production [GO:0032480]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; Toll signaling pathway [GO:0008063]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001817; GO:0002224; GO:0004842; GO:0004871; GO:0005164; GO:0005739; GO:0005768; GO:0005829; GO:0006915; GO:0007165; GO:0008063; GO:0008270; GO:0009898; GO:0016874; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032088; GO:0032480; GO:0032648; GO:0033209; GO:0035631; GO:0035666; GO:0042981; GO:0045087; GO:0050688 0 0 0 PF02176; Q15063 CHOYP_BRAFLDRAFT_127065.2.7 m.5835 sp POSTN_HUMAN 31.786 280 170 5 47 325 108 367 1.97E-35 139 POSTN_HUMAN reviewed Periostin (PN) (Osteoblast-specific factor 2) (OSF-2) POSTN OSF2 Homo sapiens (Human) 836 bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-C motif) ligand 2 secretion [GO:1904209]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; skeletal system development [GO:0001501] GO:0001501; GO:0001666; GO:0001953; GO:0003073; GO:0005578; GO:0005615; GO:0005802; GO:0007155; GO:0008201; GO:0008593; GO:0009612; GO:0014850; GO:0014911; GO:0030198; GO:0031012; GO:0031594; GO:0032355; GO:0044344; GO:0046872; GO:0050839; GO:0071307; GO:0071356; GO:0071560; GO:1900025; GO:1904209; GO:1990138; GO:1990523 0 0 0 PF02469; Q16943 CHOYP_VP33.2.2 m.11980 sp VP33_APLCA 56.274 263 76 6 1 227 1 260 1.97E-94 280 VP33_APLCA reviewed Vesicle-associated membrane protein/synaptobrevin-binding protein (VAP-33) 0 Aplysia californica (California sea hare) 260 protein localization to endoplasmic reticulum [GO:0070972] GO:0005789; GO:0016021; GO:0030054; GO:0043005; GO:0045202; GO:0070972 0 0 0 PF00635; Q20363 CHOYP_LOC100199246.1.1 m.43478 sp SIP1_CAEEL 36.25 80 49 2 204 282 49 127 1.97E-08 55.8 SIP1_CAEEL reviewed Stress-induced protein 1 sip-1 F43D9.4 Caenorhabditis elegans 159 determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; multicellular organismal protein metabolic process [GO:0044268]; response to heat [GO:0009408] GO:0005829; GO:0008340; GO:0009408; GO:0009792; GO:0044268; GO:0051082 0 0 0 PF00011; Q25381 CHOYP_LOC101072885.1.1 m.63779 sp ACTM_LYTPI 89.72 107 11 0 1 107 66 172 1.97E-69 208 ACTM_LYTPI reviewed "Actin, muscle (LPM) (Fragment)" 0 Lytechinus pictus (Painted sea urchin) 172 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q32NT4 CHOYP_LOC100376973.1.1 m.7765 sp LRC58_XENLA 48.137 322 164 3 37 357 31 350 1.97E-94 288 LRC58_XENLA reviewed Leucine-rich repeat-containing protein 58 lrrc58 Xenopus laevis (African clawed frog) 350 0 0 0 0 0 PF13855; Q3UFM5 CHOYP_LOC659901.1.1 m.348 sp NOM1_MOUSE 44.822 589 306 9 351 924 264 848 1.97E-157 487 NOM1_MOUSE reviewed Nucleolar MIF4G domain-containing protein 1 (SGD1 homolog) Nom1 Gm1040 Mus musculus (Mouse) 854 neurogenesis [GO:0022008]; ribosomal small subunit biogenesis [GO:0042274] GO:0003723; GO:0005634; GO:0005730; GO:0022008; GO:0042274; GO:0044822 0 0 0 PF02847;PF02854; Q4R4F8 CHOYP_SMN2.2.2 m.53757 sp SMN_MACFA 50 126 56 3 44 164 18 141 1.97E-29 114 SMN_MACFA reviewed Survival motor neuron protein SMN1 SMN QflA-22331 QtsA-10002 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 294 "DNA-templated transcription, termination [GO:0006353]; nervous system development [GO:0007399]; spliceosomal snRNP assembly [GO:0000387]" GO:0000387; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006353; GO:0007399; GO:0015030; GO:0030018; GO:0032797; GO:0034719; GO:0036464; GO:0043005; GO:0043204; GO:0097504 0 0 0 PF06003; Q5BJL5 CHOYP_LOC591290.3.3 m.65144 sp SBNO1_RAT 44.635 466 229 11 103 551 725 1178 1.97E-106 349 SBNO1_RAT reviewed Protein strawberry notch homolog 1 Sbno1 Rattus norvegicus (Rat) 1269 "regulation of transcription, DNA-templated [GO:0006355]" GO:0006355 0 0 0 PF13871; Q5FVM7 CHOYP_LOC100863952.1.1 m.45235 sp DJC16_RAT 29.849 794 496 21 11 773 7 770 1.97E-99 327 DJC16_RAT reviewed DnaJ homolog subfamily C member 16 Dnajc16 Rattus norvegicus (Rat) 771 cell redox homeostasis [GO:0045454] GO:0005623; GO:0016021; GO:0045454 0 0 cd06257; PF00226;PF00085; Q5FYB0 CHOYP_BRAFLDRAFT_206907.2.11 m.14814 sp ARSJ_HUMAN 38.614 101 60 2 4 103 454 553 1.97E-11 62 ARSJ_HUMAN reviewed Arylsulfatase J (ASJ) (EC 3.1.6.-) ARSJ UNQ372/PRO708 Homo sapiens (Human) 599 glycosphingolipid metabolic process [GO:0006687]; post-translational protein modification [GO:0043687] GO:0004065; GO:0005576; GO:0005788; GO:0006687; GO:0043687; GO:0046872 0 0 0 PF00884; Q5ZMM5 CHOYP_ZN706.1.2 m.11926 sp ZN706_CHICK 76.712 73 17 0 30 102 1 73 1.97E-29 103 ZN706_CHICK reviewed Zinc finger protein 706 ZNF706 RCJMB04_1j21 Gallus gallus (Chicken) 76 "negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of translation [GO:0006417]" GO:0005634; GO:0005737; GO:0006417; GO:0045892; GO:0046872; GO:1902455 0 0 0 PF04419; Q6AXU6 CHOYP_LOC101157371.1.3 m.15032 sp HN1_RAT 50 54 26 1 1 53 1 54 1.97E-06 47.4 HN1_RAT reviewed "Hematological and neurological expressed 1 protein [Cleaved into: Hematological and neurological expressed 1 protein, N-terminally processed]" Hn1 Rattus norvegicus (Rat) 149 0 GO:0005730; GO:0031965 0 0 0 PF17054; Q6PDL0 CHOYP_BRAFLDRAFT_80039.1.1 m.2568 sp DC1L2_MOUSE 51.639 488 207 10 26 495 1 477 1.97E-167 485 DC1L2_MOUSE reviewed "Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic)" Dync1li2 Dncli2 Dnclic2 Mus musculus (Mouse) 492 centrosome localization [GO:0051642]; microtubule-based movement [GO:0007018]; microtubule cytoskeleton organization [GO:0000226]; transport [GO:0006810] GO:0000226; GO:0003777; GO:0005524; GO:0005737; GO:0005813; GO:0005868; GO:0005874; GO:0006810; GO:0007018; GO:0016020; GO:0051642 0 0 0 PF05783; Q6ZQ12 CHOYP_NINL.1.2 m.56625 sp NINL_MOUSE 27.945 798 443 26 169 912 99 818 1.97E-58 226 NINL_MOUSE reviewed Ninein-like protein Ninl Kiaa0980 Nlp Mus musculus (Mouse) 1394 microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005509; GO:0005737; GO:0005815; GO:0005856; GO:0005874 0 0 0 PF13499; Q80WQ4 CHOYP_K1456.1.1 m.8318 sp K1456_MOUSE 62.179 156 59 0 12 167 6 161 1.97E-67 231 K1456_MOUSE reviewed Probable tRNA methyltransferase 9-like protein (TRM9L) (EC 2.1.1.-) Kiaa1456 Mus musculus (Mouse) 447 tRNA wobble uridine modification [GO:0002098] GO:0000049; GO:0002098; GO:0005634; GO:0005737; GO:0008175; GO:0008198; GO:0016300; GO:0016706 0 0 0 PF08241; Q8CGC6 CHOYP_LOC100703956.1.1 m.31551 sp RBM28_MOUSE 38.617 347 178 9 3 318 407 749 1.97E-55 195 RBM28_MOUSE reviewed RNA-binding protein 28 (RNA-binding motif protein 28) Rbm28 Mus musculus (Mouse) 750 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0005681; GO:0005730; GO:0006397; GO:0008380; GO:0044822 0 0 0 PF00076; Q8HXM1 CHOYP_LOC100701725.1.1 m.54512 sp CSTF2_BOVIN 56.913 311 111 10 40 335 10 312 1.97E-95 302 CSTF2_BOVIN reviewed Cleavage stimulation factor subunit 2 (CF-1 64 kDa subunit) (Cleavage stimulation factor 64 kDa subunit) (CSTF 64 kDa subunit) (CstF-64) CSTF2 Bos taurus (Bovine) 572 mRNA polyadenylation [GO:0006378]; pre-mRNA cleavage required for polyadenylation [GO:0098789] GO:0000166; GO:0003729; GO:0005847; GO:0006378; GO:0071920; GO:0098789 0 0 0 PF14327;PF14304;PF00076; Q8IYB1 CHOYP_MB21D2.1.1 m.6695 sp M21D2_HUMAN 23.881 402 275 13 14 400 24 409 1.97E-21 99.4 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q967D7 CHOYP_LOC100643265.2.2 m.51617 sp TUTL_DROME 31.395 688 405 15 21 686 246 888 1.97E-100 356 TUTL_DROME reviewed Protein turtle tutl CG15427 Drosophila melanogaster (Fruit fly) 1531 adult locomotory behavior [GO:0008344]; axonal defasciculation [GO:0007414]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite self-avoidance [GO:0070593]; flight behavior [GO:0007629]; larval behavior [GO:0030537]; lateral inhibition [GO:0046331]; mechanosensory behavior [GO:0007638]; R7 cell development [GO:0045467]; regulation of dendrite morphogenesis [GO:0048814]; sensory perception of pain [GO:0019233]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007411; GO:0007414; GO:0007629; GO:0007638; GO:0008039; GO:0008344; GO:0016199; GO:0019233; GO:0030537; GO:0045467; GO:0046331; GO:0048814; GO:0070593; GO:0098632 0 0 0 PF00041;PF07679;PF07686; Q9ESN6 CHOYP_TRIM2.26.59 m.34425 sp TRIM2_MOUSE 29.302 215 137 7 7 214 536 742 1.97E-13 72 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H2Y7 CHOYP_YTDC1.1.2 m.56405 sp ZN106_HUMAN 32.394 355 228 6 1732 2080 1527 1875 1.97E-52 208 ZN106_HUMAN reviewed Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) ZNF106 SH3BP3 ZFP106 ZNF474 Homo sapiens (Human) 1883 insulin receptor signaling pathway [GO:0008286] GO:0005730; GO:0005829; GO:0008286; GO:0016020; GO:0017124; GO:0044822; GO:0046872 0 0 0 PF00400; Q9JI44 CHOYP_DMAP1.1.1 m.34019 sp DMAP1_MOUSE 61.818 110 37 2 1 105 1 110 1.97E-39 139 DMAP1_MOUSE reviewed DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) (MAT1-mediated transcriptional repressor) Dmap1 Mmtr Mus musculus (Mouse) 468 "chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription factor import into nucleus [GO:0042993]; regulation of growth [GO:0040008]; response to ethanol [GO:0045471]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001103; GO:0003714; GO:0005634; GO:0005657; GO:0005737; GO:0006281; GO:0006338; GO:0006351; GO:0035267; GO:0040008; GO:0042993; GO:0043967; GO:0043968; GO:0045471; GO:0045892 0 0 0 PF05499;PF16282; Q9SZJ2 CHOYP_LOC100367312.10.13 m.39532 sp GRDP2_ARATH 40.426 282 152 5 7 275 17 295 1.97E-57 213 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; Q9U1H8 CHOYP_LOC100115515.1.1 m.9472 sp FACE2_DROME 43.273 275 151 4 13 287 30 299 1.97E-73 230 FACE2_DROME reviewed CAAX prenyl protease 2 (EC 3.4.22.-) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (Protein severas) Sras CG4852 Drosophila melanogaster (Fruit fly) 302 CAAX-box protein processing [GO:0071586] GO:0004197; GO:0004222; GO:0030176; GO:0071586 0 0 0 PF02517; Q9U3S9 CHOYP_LOC100207248.1.1 m.8835 sp NAS6_CAEEL 39.063 192 114 2 117 308 77 265 1.97E-37 145 NAS6_CAEEL reviewed Zinc metalloproteinase nas-6 (EC 3.4.24.21) (Nematode astacin 6) nas-6 4R79.1 Caenorhabditis elegans 344 pharyngeal pumping [GO:0043050]; pharynx development [GO:0060465] GO:0004222; GO:0005576; GO:0008270; GO:0043050; GO:0060465 0 0 0 PF01400;PF01549; Q9Y2V2 CHOYP_BRAFLDRAFT_206907.11.11 m.60961 sp CHSP1_HUMAN 63.063 111 41 0 42 152 30 140 1.97E-44 146 CHSP1_HUMAN reviewed Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) CARHSP1 Homo sapiens (Human) 147 "intracellular signal transduction [GO:0035556]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000177; GO:0000932; GO:0003677; GO:0003730; GO:0005829; GO:0006355; GO:0019902; GO:0035556; GO:0043186; GO:0043488; GO:0070062 0 0 cd04458; PF00313; A2AQ19 CHOYP_RTF1.1.1 m.10685 sp RTF1_MOUSE 47.346 716 307 13 1 692 46 715 1.98E-161 484 RTF1_MOUSE reviewed RNA polymerase-associated protein RTF1 homolog Rtf1 Mus musculus (Mouse) 715 blastocyst growth [GO:0001832]; endodermal cell fate commitment [GO:0001711]; histone H3-K4 trimethylation [GO:0080182]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; stem cell population maintenance [GO:0019827]; transcription elongation from RNA polymerase II promoter [GO:0006368]; Wnt signaling pathway [GO:0016055] GO:0000122; GO:0001711; GO:0001832; GO:0003697; GO:0005730; GO:0006368; GO:0016055; GO:0016593; GO:0019827; GO:0032968; GO:0044822; GO:0045944; GO:0051571; GO:0080182 0 0 0 PF03126; B1WB06 CHOYP_PHYD1.1.2 m.17821 sp MET24_XENTR 29.605 152 91 5 138 283 148 289 1.98E-12 70.9 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; B3EWY9 CHOYP_LOC590125.6.7 m.53735 sp MLP_ACRMI 29.295 1106 622 35 305 1350 369 1374 1.98E-112 400 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; G4V4G1 CHOYP_LOC769726.1.1 m.26365 sp IGFBP_CUPSA 37.288 236 137 3 27 252 21 255 1.98E-50 169 IGFBP_CUPSA reviewed Insulin-like growth factor-binding protein-related protein 1 (IGFBP-rP1) 0 Cupiennius salei (American wandering spider) 261 regulation of cell growth [GO:0001558] GO:0001558; GO:0004867; GO:0005576 0 0 0 PF00219;PF00050; O15990 CHOYP_KARG.11.11 m.50802 sp KARG_LIOJA 82.353 102 18 0 1 102 247 348 1.98E-54 175 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O35161 CHOYP_FAT3.2.3 m.35928 sp CELR1_MOUSE 24.694 409 251 18 84 473 785 1155 1.98E-10 67.4 CELR1_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 1 Celsr1 Mus musculus (Mouse) 3034 anterior/posterior pattern specification [GO:0009952]; apical protein localization [GO:0045176]; cell-cell signaling [GO:0007267]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; gastrulation with mouth forming second [GO:0001702]; G-protein coupled receptor signaling pathway [GO:0007186]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear morphogenesis [GO:0042472]; lateral sprouting involved in lung morphogenesis [GO:0060490]; locomotory behavior [GO:0007626]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of neurotransmitter secretion [GO:0046928]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; wound healing [GO:0042060] GO:0001702; GO:0001736; GO:0001764; GO:0001843; GO:0001942; GO:0004888; GO:0004930; GO:0005509; GO:0005654; GO:0005886; GO:0005887; GO:0007156; GO:0007165; GO:0007186; GO:0007266; GO:0007267; GO:0007417; GO:0007626; GO:0009952; GO:0016020; GO:0032956; GO:0042060; GO:0042249; GO:0042472; GO:0045176; GO:0046928; GO:0046983; GO:0048105; GO:0060488; GO:0060489; GO:0060490; GO:0090179; GO:0090251 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF02793;PF00053;PF02210; O35817 CHOYP_LOC100374430.1.1 m.7155 sp AKA14_RAT 41.844 141 78 2 53 191 361 499 1.98E-33 127 AKA14_RAT reviewed A-kinase anchor protein 14 (AKAP-14) (TAKAP-1.2) (Testis-specific A-kinase-anchoring protein TAKAP-80) Akap14 Takap80 Rattus norvegicus (Rat) 502 spermatogenesis [GO:0007283] GO:0005737; GO:0007283; GO:0035686; GO:0051018 0 0 0 PF14469; P02595 CHOYP_LOC100208382.1.1 m.12145 sp CALM_PATSP 36.17 141 89 1 47 187 5 144 1.98E-22 91.3 CALM_PATSP reviewed Calmodulin (CaM) 0 Patinopecten sp. (Scallop) 149 0 GO:0005509 0 0 0 PF13499; P06868 CHOYP_CGB_G5670C.1.1 m.60953 sp PLMN_BOVIN 49.727 183 74 6 1342 1509 189 368 1.98E-42 172 PLMN_BOVIN reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; response to heat [GO:0009408]; tissue remodeling [GO:0048771] GO:0004252; GO:0005102; GO:0005576; GO:0007596; GO:0009408; GO:0019904; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P0C7B7 CHOYP_SMP_135040.1.1 m.1967 sp ELIC_DICCH 25.461 271 184 6 70 329 5 268 1.98E-15 80.1 ELIC_DICCH reviewed Cys-loop ligand-gated ion channel (ELIC) 0 Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) 321 0 GO:0005230; GO:0005886; GO:0016021 0 0 0 PF02931; P11714 CHOYP_CP2D9.1.2 m.2817 sp CP2D9_MOUSE 29.307 505 331 9 6 497 9 500 1.98E-63 217 CP2D9_MOUSE reviewed Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (Cytochrome P450-16-alpha) (Cytochrome P450CA) (Testosterone 16-alpha hydroxylase) Cyp2d9 Cyp2d-9 Mus musculus (Mouse) 504 arachidonic acid metabolic process [GO:0019369] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019369; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P39429 CHOYP_BRAFLDRAFT_68997.1.1 m.56357 sp TRAF2_MOUSE 40.842 546 262 10 1 533 1 498 1.98E-143 425 TRAF2_MOUSE reviewed TNF receptor-associated factor 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF2) Traf2 Mus musculus (Mouse) 501 activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cellular protein complex assembly [GO:0043623]; cellular response to nitric oxide [GO:0071732]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glial cell apoptotic process [GO:0034351]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein heterooligomerization [GO:0051291]; protein homotrimerization [GO:0070207]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; regulation of immunoglobulin secretion [GO:0051023]; regulation of JNK cascade [GO:0046328]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0000151; GO:0002726; GO:0004842; GO:0005164; GO:0005174; GO:0005737; GO:0005829; GO:0005938; GO:0006915; GO:0007165; GO:0007250; GO:0008270; GO:0009898; GO:0012506; GO:0016874; GO:0019899; GO:0019901; GO:0019903; GO:0030163; GO:0031625; GO:0031996; GO:0032743; GO:0033209; GO:0034351; GO:0035631; GO:0042802; GO:0042981; GO:0043066; GO:0043123; GO:0043507; GO:0043623; GO:0045121; GO:0046328; GO:0046625; GO:0051023; GO:0051091; GO:0051092; GO:0051291; GO:0051865; GO:0070207; GO:0070534; GO:0071732; GO:0090073; GO:0097057; GO:0097300; GO:1903265; GO:1903721; GO:1990604; GO:2001238 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF16673;PF00097;PF02176; P52786 CHOYP_MYSP.8.9 m.44814 sp CP2J1_RABIT 28.717 491 322 10 9 483 21 499 1.98E-53 190 CP2J1_RABIT reviewed Cytochrome P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (Cytochrome P-450IB) CYP2J1 Oryctolagus cuniculus (Rabbit) 501 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P54922 CHOYP_ADPRH.1.1 m.52834 sp ADPRH_HUMAN 54.785 303 130 4 109 409 3 300 1.98E-103 315 ADPRH_HUMAN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Homo sapiens (Human) 357 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; P98197 CHOYP_LOC101067743.1.1 m.2149 sp AT11A_MOUSE 34.234 111 66 4 1 108 1022 1128 1.98E-09 58.2 AT11A_MOUSE reviewed Probable phospholipid-transporting ATPase IH (EC 3.6.3.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) Atp11a Mus musculus (Mouse) 1187 0 GO:0000287; GO:0004012; GO:0005524; GO:0005765; GO:0005769; GO:0005783; GO:0005886; GO:0016020; GO:0016021; GO:0043231; GO:0055037 0 0 0 PF00122;PF16212;PF16209; Q00725 CHOYP_contig_039481 m.44701 sp SGS4_DROME 45.732 164 77 4 44 205 22 175 1.98E-11 66.6 SGS4_DROME reviewed Salivary glue protein Sgs-4 Sgs4 Sgs-4 CG12181 Drosophila melanogaster (Fruit fly) 297 0 GO:0005576 0 0 0 0 Q01664 CHOYP_CEG1A.2.6 m.3124 sp TFAP4_HUMAN 56.863 153 46 4 42 190 43 179 1.98E-41 150 TFAP4_HUMAN reviewed Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41) TFAP4 BHLHC41 Homo sapiens (Human) 338 "cellular response to dexamethasone stimulus [GO:0071549]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of DNA binding [GO:0043392]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation by host of viral transcription [GO:0043923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of transcription, DNA-templated [GO:0045893]; protein complex assembly [GO:0006461]" GO:0000978; GO:0001077; GO:0003677; GO:0003705; GO:0005634; GO:0006461; GO:0006978; GO:0008285; GO:0017053; GO:0042803; GO:0042826; GO:0043065; GO:0043392; GO:0043565; GO:0043922; GO:0043923; GO:0044212; GO:0045736; GO:0045892; GO:0045893; GO:0070888; GO:0071157; GO:0071549; GO:2001269 0 0 0 PF00010; Q04831 CHOYP_GLNA.3.5 m.18490 sp GLNA_PANAR 78.571 84 18 0 16 99 276 359 1.98E-40 139 GLNA_PANAR reviewed Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) 0 Panulirus argus (Caribbean spiny lobster) (Palinurus argus) 361 glutamine biosynthetic process [GO:0006542] GO:0004356; GO:0005524; GO:0005737; GO:0006542 0 0 0 PF00120;PF03951; Q06852 CHOYP_043R.5.5 m.64252 sp SLAP1_CLOTH 52.381 294 80 24 575 816 1351 1636 1.98E-16 88.2 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q08879 CHOYP_LOC100634184.1.3 m.3401 sp FBLN1_MOUSE 33.544 474 202 23 46 469 201 611 1.98E-47 183 FBLN1_MOUSE reviewed Fibulin-1 (FIBL-1) (Basement-membrane protein 90) (BM-90) Fbln1 Mus musculus (Mouse) 705 "blood coagulation, fibrin clot formation [GO:0072378]; embryo implantation [GO:0007566]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of transformation of host cell by virus [GO:1904188]; negative regulation of transforming growth factor-beta secretion [GO:2001202]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]" GO:0001933; GO:0001968; GO:0005201; GO:0005509; GO:0005577; GO:0005578; GO:0005604; GO:0005615; GO:0007162; GO:0007566; GO:0008022; GO:0010628; GO:0016504; GO:0030198; GO:0032403; GO:0042802; GO:0048146; GO:0070051; GO:0070062; GO:0070373; GO:0071953; GO:0072378; GO:1900025; GO:1904188; GO:1904237; GO:2000146; GO:2000647; GO:2001202 0 0 0 PF12662;PF07645; Q09654 CHOYP_LOC100376215.9.19 m.32713 sp TRI23_CAEEL 30.097 103 64 4 24 120 119 219 1.98E-06 52.8 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q0EEE2 CHOYP_LOC100372915.3.7 m.25794 sp PTHD3_MOUSE 27.615 851 544 19 19 828 84 903 1.98E-102 341 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q0VC84 CHOYP_LOC100496837.1.1 m.31633 sp C1GLT_BOVIN 37.241 290 169 7 51 335 49 330 1.98E-58 197 C1GLT_BOVIN reviewed "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GALT1 Bos taurus (Bovine) 368 "angiogenesis [GO:0001525]; intestinal epithelial cell development [GO:0060576]; kidney development [GO:0001822]; O-glycan processing, core 1 [GO:0016267]" GO:0001525; GO:0001822; GO:0016021; GO:0016263; GO:0016267; GO:0046872; GO:0060576 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02434; Q13310 CHOYP_PABP4.6.6 m.58055 sp PABP4_HUMAN 59.383 389 135 6 48 425 257 633 1.98E-137 411 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q15262 CHOYP_PTPRT.10.45 m.36083 sp PTPRK_HUMAN 40.426 188 104 3 78 263 904 1085 1.98E-34 134 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q460N5 CHOYP_BRAFLDRAFT_84838.3.6 m.42355 sp PAR14_HUMAN 28.162 1708 1086 48 510 2173 190 1800 1.98E-158 540 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_LOC100367084.16.22 m.54706 sp SVEP1_HUMAN 25.847 708 420 25 42 680 435 1106 1.98E-37 158 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4LDE5 CHOYP_LOC100893288.1.1 m.65287 sp SVEP1_HUMAN 29.56 159 94 3 165 317 998 1144 1.98E-08 60.1 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5RBP9 CHOYP_MPEG1.3.5 m.25453 sp MPEG1_PONAB 37.868 713 391 15 32 721 8 691 1.98E-157 475 MPEG1_PONAB reviewed Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 716 0 GO:0016021 0 0 0 PF01823; Q5RJ80 CHOYP_contig_043085 m.49734 sp CAPR2_DANRE 30.435 138 86 5 29 158 776 911 1.98E-07 52.8 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q6A548 CHOYP_TERT.2.2 m.25118 sp TERT_CANLF 40.217 276 155 5 25 292 804 1077 1.98E-58 205 TERT_CANLF reviewed Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) TERT Canis lupus familiaris (Dog) (Canis familiaris) 1123 telomere maintenance via telomerase [GO:0007004] GO:0000333; GO:0000781; GO:0003721; GO:0005730; GO:0005737; GO:0007004; GO:0016605; GO:0042162; GO:0046872; GO:0070034 0 0 0 PF00078;PF12009; Q7RTX9 CHOYP_SLC16A9.1.1 m.25191 sp MOT14_HUMAN 28.796 382 250 11 13 385 135 503 1.98E-33 134 MOT14_HUMAN reviewed Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) 510 0 GO:0005886; GO:0008028; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q80WQ8 CHOYP_M18BP.1.2 m.24889 sp M18BP_MOUSE 27.863 262 154 11 47 285 746 995 1.98E-18 89 M18BP_MOUSE reviewed Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) Mis18bp1 Kiaa1903 Knl2 M18bp1 Mus musculus (Mouse) 998 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0000778; GO:0003677; GO:0007067; GO:0051301 0 0 0 PF00249;PF09133; Q8BGC4 CHOYP_LOC100638977.1.1 m.65819 sp ZADH2_MOUSE 52.97 202 94 1 28 229 177 377 1.98E-69 220 ZADH2_MOUSE reviewed Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-) Zadh2 Mus musculus (Mouse) 377 0 GO:0005739; GO:0005777; GO:0008270; GO:0016491 0 0 0 PF08240;PF00107; Q8BV57 CHOYP_BRAFLDRAFT_77841.1.1 m.45720 sp SRCRL_MOUSE 47.863 117 59 2 405 519 742 858 1.98E-28 124 SRCRL_MOUSE reviewed Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Scavenger receptor cysteine-rich domain-containing protein LOC284297 homolog) Ssc5d S5D-SRCRB Mus musculus (Mouse) 1371 defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; negative regulation of interleukin-8 secretion [GO:2000483]; regulation of interleukin-8 secretion [GO:2000482] GO:0001968; GO:0005044; GO:0005615; GO:0005622; GO:0005737; GO:0006952; GO:0007275; GO:0016020; GO:0031012; GO:0042494; GO:0043236; GO:0045087; GO:0050829; GO:0050830; GO:0050840; GO:2000482; GO:2000483 0 0 0 PF00530; Q8C8N3 CHOYP_VWCE.3.3 m.38898 sp VWC2_MOUSE 36.782 87 50 2 46 132 220 301 1.98E-07 52 VWC2_MOUSE reviewed Brorin (Brain-specific chordin-like protein) (CR (chordin-like cysteine-rich) domain-containing adhesive protein) (Cradin) (von Willebrand factor C domain-containing protein 2) Vwc2 Mus musculus (Mouse) 324 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666] GO:0005578; GO:0005604; GO:0005614; GO:0005615; GO:0010811; GO:0030054; GO:0030514; GO:0032281; GO:0045202; GO:0045666 0 0 0 PF00093; Q8N8U9 CHOYP_BMPER.1.1 m.10107 sp BMPER_HUMAN 42.769 650 358 8 33 677 43 683 1.98E-178 527 BMPER_HUMAN reviewed BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2) BMPER KIAA1965 Homo sapiens (Human) 685 blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; endothelial cell activation [GO:0042118]; endothelial cell differentiation [GO:0045446]; inner ear development [GO:0048839]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of endothelial cell migration [GO:0010594]; regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393]; ureteric bud development [GO:0001657] GO:0001657; GO:0002043; GO:0005615; GO:0010594; GO:0030514; GO:0042118; GO:0045446; GO:0048839; GO:0060393; GO:0070374 0 0 0 PF08742;PF01826;PF00093;PF00094; Q8SZ16 CHOYP_CG14898.1.1 m.23768 sp SDHF3_DROME 50.862 116 52 2 1 113 6 119 1.98E-32 113 SDHF3_DROME reviewed "Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)" Sdhaf3 CG14898 Drosophila melanogaster (Fruit fly) 120 musculoskeletal movement [GO:0050881]; response to hyperoxia [GO:0055093]; response to oxidative stress [GO:0006979]; succinate metabolic process [GO:0006105] GO:0005759; GO:0006105; GO:0006979; GO:0050881; GO:0055093 0 0 0 0 Q90W58 CHOYP_LOC100889680.1.1 m.9997 sp DUS1B_XENLA 38.298 141 85 1 19 159 178 316 1.98E-26 105 DUS1B_XENLA reviewed Dual specificity protein phosphatase 1-B (EC 3.1.3.16) (EC 3.1.3.48) (XCL100-beta) dusp1-b Xenopus laevis (African clawed frog) 369 inactivation of MAPK activity [GO:0000188]; meiotic cell cycle [GO:0051321]; mitotic cell cycle arrest [GO:0071850]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of meiotic cell cycle [GO:0051447]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] GO:0000188; GO:0004725; GO:0005634; GO:0005737; GO:0017017; GO:0035335; GO:0035970; GO:0043409; GO:0051321; GO:0051447; GO:0071850; GO:0090266 0 0 0 PF00782; Q96EQ9 CHOYP_PRDM9.1.1 m.45317 sp PRDM9_MOUSE 35.284 598 312 15 21 550 27 617 1.98E-94 309 PRDM9_MOUSE reviewed Histone-lysine N-methyltransferase PRDM9 (EC 2.1.1.43) (Hybrid sterility protein 1) (Meiosis-induced factor containing a PR/SET domain and zinc-finger motif) (PR domain zinc finger protein 9) (PR domain-containing protein 9) Prdm9 Hst1 Meisetz Mus musculus (Mouse) 843 "histone lysine methylation [GO:0034968]; histone methylation [GO:0016571]; meiotic gene conversion [GO:0006311]; positive regulation of meiosis I [GO:0060903]; positive regulation of reciprocal meiotic recombination [GO:0010845]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0005654; GO:0005694; GO:0006311; GO:0006351; GO:0007283; GO:0010844; GO:0010845; GO:0016571; GO:0034968; GO:0042800; GO:0043565; GO:0045944; GO:0046872; GO:0060903 0 0 cd07765; PF01352;PF00856;PF09514;PF00096; Q96RW7 CHOYP_LOC100167052.1.1 m.36341 sp HMCN1_HUMAN 27.083 240 136 13 3 221 1759 1980 1.98E-10 67.8 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99JX1 CHOYP_AAEL_AAEL014850.1.1 m.21635 sp TAF11_MOUSE 72.277 101 28 0 89 189 100 200 1.98E-48 160 TAF11_MOUSE reviewed Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28) Taf11 Mus musculus (Mouse) 211 "positive regulation by host of viral transcription [GO:0043923]; regulation of transcription, DNA-templated [GO:0006355]; RNA polymerase II transcriptional preinitiation complex assembly [GO:0051123]" GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005669; GO:0005794; GO:0006355; GO:0008134; GO:0042809; GO:0043923; GO:0046966; GO:0047485; GO:0051123 0 0 cd08048; PF04719; Q99M80 CHOYP_PTPRT.15.45 m.41695 sp PTPRT_MOUSE 29.558 724 435 13 10 693 765 1453 1.98E-88 306 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BXF3 CHOYP_CECR2.3.3 m.59311 sp CECR2_HUMAN 59.146 164 62 2 24 187 11 169 1.98E-55 216 CECR2_HUMAN reviewed Cat eye syndrome critical region protein 2 CECR2 KIAA1740 Homo sapiens (Human) 1484 apoptotic DNA fragmentation [GO:0006309]; ATP-dependent chromatin remodeling [GO:0043044]; covalent chromatin modification [GO:0016569]; cytokinesis [GO:0000910]; cytoskeleton organization [GO:0007010]; execution phase of apoptosis [GO:0097194]; neural tube development [GO:0021915]; vesicle-mediated transport [GO:0016192] GO:0000910; GO:0005634; GO:0006309; GO:0007010; GO:0016192; GO:0016569; GO:0021915; GO:0043044; GO:0090537; GO:0097194 0 0 0 PF00439; Q9DA08 CHOYP_BRAFLDRAFT_125533.1.1 m.56706 sp SGF29_MOUSE 67.918 293 83 3 55 337 2 293 1.98E-147 420 SGF29_MOUSE reviewed SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) Sgf29 Ccdc101 Mus musculus (Mouse) 293 "histone H3 acetylation [GO:0043966]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005671; GO:0006351; GO:0006355; GO:0035064; GO:0043966; GO:0070461 0 0 0 PF07039; Q9HAR2 CHOYP_LOC100891565.1.1 m.60563 sp AGRL3_HUMAN 26.624 631 406 20 903 1496 500 1110 1.98E-53 210 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9NP59 CHOYP_LOC577187.1.1 m.16584 sp S40A1_HUMAN 39.516 248 127 6 1 246 345 571 1.98E-44 160 S40A1_HUMAN reviewed Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) SLC40A1 FPN1 IREG1 SLC11A3 MSTP079 Homo sapiens (Human) 571 cellular iron ion homeostasis [GO:0006879]; endothelium development [GO:0003158]; ferrous iron export [GO:1903988]; iron ion transmembrane transport [GO:0034755]; lymphocyte homeostasis [GO:0002260]; multicellular organismal iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395]; spleen trabecula formation [GO:0060345] GO:0002260; GO:0003158; GO:0004872; GO:0005381; GO:0005622; GO:0005737; GO:0005771; GO:0005886; GO:0005887; GO:0006879; GO:0008021; GO:0015093; GO:0016021; GO:0016323; GO:0017046; GO:0034395; GO:0034755; GO:0043066; GO:0045944; GO:0060345; GO:0060586; GO:0097689; GO:1903988 0 0 0 PF06963; Q9NVD3 CHOYP_LOC764875.1.1 m.17481 sp SETD4_HUMAN 34.005 397 241 6 5 386 6 396 1.98E-63 213 SETD4_HUMAN reviewed SET domain-containing protein 4 (EC 2.1.1.-) SETD4 C21orf18 C21orf27 Homo sapiens (Human) 440 peptidyl-lysine monomethylation [GO:0018026]; peptidyl-lysine trimethylation [GO:0018023]; ribosome biogenesis [GO:0042254] GO:0005730; GO:0016279; GO:0018023; GO:0018026; GO:0042254 0 0 0 PF09273;PF00856; Q9NZQ3 CHOYP_LOC100374747.1.1 m.54969 sp SPN90_HUMAN 37.653 409 249 3 339 743 308 714 1.98E-80 275 SPN90_HUMAN reviewed NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein) NCKIPSD AF3P21 SPIN90 Homo sapiens (Human) 722 cytoskeleton organization [GO:0007010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of neuron projection development [GO:0010976]; signal transduction [GO:0007165] GO:0005634; GO:0005829; GO:0005882; GO:0006607; GO:0007010; GO:0007165; GO:0008092; GO:0010976; GO:0038096 0 0 0 PF09431;PF00018; Q9P2K8 CHOYP_BRAFLDRAFT_71943.1.1 m.33790 sp E2AK4_HUMAN 37.598 508 262 14 4 498 17 482 1.98E-79 273 E2AK4_HUMAN reviewed eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein) EIF2AK4 GCN2 KIAA1338 Homo sapiens (Human) 1649 adaptive immune response [GO:0002250]; cell cycle arrest [GO:0007050]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to leucine starvation [GO:1990253]; cellular response to UV [GO:0034644]; defense response to virus [GO:0051607]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; induction by virus of host autophagy [GO:0039520]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of CREB transcription factor activity [GO:0032792]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; neuron projection extension [GO:1990138]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of translational initiation in response to starvation [GO:0071264]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of eIF2 alpha phosphorylation by amino acid starvation [GO:0060733]; regulation of feeding behavior [GO:0060259]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; T cell activation involved in immune response [GO:0002286]; viral translation [GO:0019081] GO:0000049; GO:0002230; GO:0002250; GO:0002286; GO:0002821; GO:0004674; GO:0004694; GO:0005524; GO:0005844; GO:0006446; GO:0006468; GO:0007050; GO:0007612; GO:0007616; GO:0010998; GO:0019081; GO:0022626; GO:0032057; GO:0032792; GO:0034198; GO:0034644; GO:0036492; GO:0039520; GO:0044828; GO:0045665; GO:0045947; GO:0046777; GO:0051607; GO:0060259; GO:0060733; GO:0070417; GO:0071264; GO:1900273; GO:1990138; GO:1990253 0 0 0 PF12745;PF00069;PF05773; Q9TTS3 CHOYP_ACACA.3.7 m.41507 sp ACACA_BOVIN 61.207 116 40 1 1 111 1604 1719 1.98E-41 147 ACACA_BOVIN reviewed Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACACA ACAC ACCA Bos taurus (Bovine) 2346 acetyl-CoA metabolic process [GO:0006084]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289] GO:0003989; GO:0004075; GO:0005524; GO:0005829; GO:0006084; GO:0006633; GO:0046872; GO:0051289; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; Q9U0M8 CHOYP_BRAFLDRAFT_241880.1.1 m.17324 sp YPF06_PLAF7 39.683 63 38 0 54 116 270 332 1.98E-06 48.5 YPF06_PLAF7 reviewed Uncharacterized protein PFA0635c PFA0635c Plasmodium falciparum (isolate 3D7) 584 0 GO:0016021 0 0 0 0 Q9VCA8 CHOYP_DGRI_GH18670.1.1 m.53919 sp ANKHM_DROME 39.881 168 96 4 1 163 633 800 1.98E-25 105 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9Y6E0 CHOYP_PHUM_PHUM071280.1.1 m.25507 sp STK24_HUMAN 69.146 363 92 5 8 363 28 377 1.98E-162 472 STK24_HUMAN reviewed Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] STK24 MST3 STK3 Homo sapiens (Human) 443 cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; mitotic cell cycle [GO:0000278]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; response to hydrogen peroxide [GO:0042542]; signal transduction [GO:0007165] GO:0000278; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005913; GO:0006468; GO:0006921; GO:0007165; GO:0008631; GO:0016020; GO:0030336; GO:0042542; GO:0046777; GO:0046872; GO:0048679; GO:0070062; GO:0097194; GO:0098641 0 0 0 PF00069; Q9Y7M3 CHOYP_RL13.3.4 m.34509 sp YNT3_SCHPO 38.961 77 43 2 45 119 144 218 1.98E-09 59.7 YNT3_SCHPO reviewed FYVE-type zinc finger-containing protein C9B6.03 SPBC9B6.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 293 endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; Golgi to endosome transport [GO:0006895]; Golgi to vacuole transport [GO:0006896]; vacuole inheritance [GO:0000011] GO:0000011; GO:0000324; GO:0005829; GO:0006895; GO:0006896; GO:0006897; GO:0010009; GO:0017137; GO:0034058; GO:0046872 0 0 0 PF01363; A7YY35 CHOYP_LOC100376186.5.7 m.57058 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 1.99E-19 98.2 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; B0V2N1 CHOYP_PTPRF.6.6 m.51830 sp PTPRS_MOUSE 30.679 427 278 8 169 586 1258 1675 1.99E-60 221 PTPRS_MOUSE reviewed Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (PTPNU-3) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) Ptprs Mus musculus (Mouse) 1907 cell adhesion [GO:0007155]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; peptidyl-tyrosine dephosphorylation [GO:0035335]; spinal cord development [GO:0021510] GO:0004725; GO:0007155; GO:0016021; GO:0021510; GO:0021549; GO:0021766; GO:0021987; GO:0022038; GO:0035335; GO:0070062; GO:0090557 0 0 0 PF00041;PF07679;PF00102; C3ZAH2 CHOYP_MTND.1.3 m.16109 sp MTND_BRAFL 72.917 96 26 0 23 118 78 173 1.99E-48 155 MTND_BRAFL reviewed "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (EC 1.13.11.54) (Acireductone dioxygenase (Fe(2+)-requiring)) (ARD) (Fe-ARD)" BRAFLDRAFT_119977 Branchiostoma floridae (Florida lancelet) (Amphioxus) 177 L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; methionine metabolic process [GO:0006555] GO:0005506; GO:0005634; GO:0005737; GO:0006555; GO:0010309; GO:0019509 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. {ECO:0000255|HAMAP-Rule:MF_03154}. 0 0 PF03079; C8YR32 CHOYP_BRAFLDRAFT_67580.2.2 m.34694 sp LOXH1_MOUSE 26.716 1632 1037 50 15 1537 484 2065 1.99E-131 463 LOXH1_MOUSE reviewed Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) 2068 detection of mechanical stimulus [GO:0050982]; sensory perception of sound [GO:0007605] GO:0005262; GO:0007605; GO:0016020; GO:0032420; GO:0050982 0 0 0 PF01477; O02833 CHOYP_TLR8.1.2 m.35121 sp ALS_PAPHA 23.842 583 329 20 25 575 32 531 1.99E-16 86.7 ALS_PAPHA reviewed Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Papio hamadryas (Hamadryas baboon) 605 cell adhesion [GO:0007155] GO:0005615; GO:0007155 0 0 0 PF13855;PF01462; O15016 CHOYP_BRAFLDRAFT_80400.4.4 m.51258 sp TRI66_HUMAN 25.389 193 121 5 22 194 16 205 1.99E-06 54.3 TRI66_HUMAN reviewed Tripartite motif-containing protein 66 TRIM66 C11orf29 KIAA0298 Homo sapiens (Human) 1216 0 GO:0005654; GO:0008270; GO:0016235 0 0 0 PF00439;PF00628;PF00643; O35815 CHOYP_BRAFLDRAFT_126822.1.1 m.14626 sp ATX3_RAT 48.116 345 141 8 1 321 1 331 1.99E-101 306 ATX3_RAT reviewed Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1 homolog) Atxn3 Mjd Sca3 Rattus norvegicus (Rat) 355 "actin cytoskeleton organization [GO:0030036]; cellular response to heat [GO:0034605]; cellular response to misfolded protein [GO:0071218]; exploration behavior [GO:0035640]; histone H3 deacetylation [GO:0070932]; intermediate filament cytoskeleton organization [GO:0045104]; microtubule cytoskeleton organization [GO:0000226]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; monoubiquitinated protein deubiquitination [GO:0035520]; positive regulation of ERAD pathway [GO:1904294]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein localization to cytosolic proteasome complex involved in ERAD pathway [GO:1904379]; regulation of cell-substrate adhesion [GO:0010810]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000226; GO:0001012; GO:0004843; GO:0005634; GO:0005759; GO:0005789; GO:0005829; GO:0006351; GO:0006355; GO:0006515; GO:0008242; GO:0010810; GO:0030036; GO:0031625; GO:0031966; GO:0034605; GO:0035520; GO:0035640; GO:0042405; GO:0042802; GO:0043161; GO:0045104; GO:0051117; GO:0061578; GO:0070536; GO:0070932; GO:0071108; GO:0071218; GO:1904294; GO:1904379; GO:1990380 0 0 0 PF02099;PF02809; O43657 CHOYP_PHUM_PHUM105960.1.1 m.29740 sp TSN6_HUMAN 25.703 249 138 8 8 243 16 230 1.99E-11 65.5 TSN6_HUMAN reviewed Tetraspanin-6 (Tspan-6) (A15 homolog) (Putative NF-kappa-B-activating protein 321) (T245 protein) (Tetraspanin TM4-D) (Transmembrane 4 superfamily member 6) TSPAN6 TM4SF6 UNQ767/PRO1560 Homo sapiens (Human) 245 cell surface receptor signaling pathway [GO:0007166]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005887; GO:0007166; GO:0039532; GO:0043123; GO:0070062; GO:1901223 0 0 0 PF00335; O75382 CHOYP_contig_045362 m.52730 sp TRIM3_HUMAN 26.829 123 84 4 198 315 622 743 1.99E-07 56.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06857 CHOYP_LIPR1.1.3 m.827 sp LIPR1_CANLF 43.902 328 164 9 31 347 11 329 1.99E-84 267 LIPR1_CANLF reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Canis lupus familiaris (Dog) (Canis familiaris) 467 lipid catabolic process [GO:0016042] GO:0005509; GO:0005576; GO:0016042; GO:0052689 0 0 0 PF00151;PF01477; P08962 CHOYP_LOC751836.2.6 m.25437 sp CD63_HUMAN 27.239 268 150 10 1 267 1 224 1.99E-12 68.6 CD63_HUMAN reviewed CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) CD63 MLA1 TSPAN30 Homo sapiens (Human) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cellular protein localization [GO:0034613]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigment granule maturation [GO:0048757]; platelet degranulation [GO:0002576]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of rubidium ion transport [GO:2000680]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0002576; GO:0005615; GO:0005765; GO:0005886; GO:0005887; GO:0007160; GO:0009986; GO:0010008; GO:0010633; GO:0015031; GO:0016477; GO:0030855; GO:0031088; GO:0031226; GO:0031902; GO:0031904; GO:0032585; GO:0034613; GO:0035646; GO:0042470; GO:0043234; GO:0045785; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2000680; GO:2001046 0 0 0 PF00335; P10079 CHOYP_LOC100634060.32.37 m.65136 sp FBP1_STRPU 53.503 157 73 0 1 157 321 477 1.99E-47 167 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10394 CHOYP_LOC100370477.1.2 m.13653 sp POL4_DROME 29.388 735 436 17 2 679 515 1223 1.99E-79 283 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P10688 CHOYP_PLCD1.1.1 m.63908 sp PLCD1_RAT 41.215 757 399 17 35 761 16 756 1.99E-179 535 PLCD1_RAT reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)" Plcd1 Rattus norvegicus (Rat) 756 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; lipid catabolic process [GO:0016042]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482]; positive regulation of inositol trisphosphate biosynthetic process [GO:0032962]; positive regulation of norepinephrine secretion [GO:0010701]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of phospholipase C activity [GO:1900274]; response to aluminum ion [GO:0010044]; response to calcium ion [GO:0051592]; response to hyperoxia [GO:0055093]; response to organonitrogen compound [GO:0010243]; response to peptide hormone [GO:0043434]; response to prostaglandin F [GO:0034696] GO:0004435; GO:0004871; GO:0005509; GO:0005543; GO:0005546; GO:0005634; GO:0005829; GO:0007186; GO:0010044; GO:0010243; GO:0010701; GO:0016020; GO:0016042; GO:0031966; GO:0032962; GO:0034696; GO:0035556; GO:0043434; GO:0045121; GO:0051480; GO:0051482; GO:0051592; GO:0055093; GO:1900274 0 0 0 PF00168;PF09279;PF16457;PF00388;PF00387; P11833 CHOYP_LOC373275.2.7 m.14496 sp TBB_PARLI 95.812 191 8 0 22 212 1 191 1.99E-126 367 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P13846 CHOYP_LOC100485640.1.1 m.21128 sp DPOL_HHBV 27.439 164 114 4 205 367 448 607 1.99E-08 60.8 DPOL_HHBV reviewed Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Heron hepatitis B virus (HHBV) 788 DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006260; GO:0046872 0 0 0 PF00336;PF00242;PF00078; P18433 CHOYP_PTPRK.13.20 m.40023 sp PTPRA_HUMAN 29.942 688 429 18 762 1426 137 794 1.99E-86 303 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P27393 CHOYP_CPIPJ_CPIJ000723.1.1 m.7190 sp CO4A2_ASCSU 45.625 160 66 1 1 160 1285 1423 1.99E-19 91.3 CO4A2_ASCSU reviewed Collagen alpha-2(IV) chain 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 1763 0 GO:0005201; GO:0005581; GO:0005604 0 0 0 PF01413;PF01391; P49013 CHOYP_contig_022718 m.25962 sp FBP3_STRPU 58.108 74 31 0 83 156 178 251 1.99E-22 100 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P55866 CHOYP_LOC100876771.1.1 m.66130 sp CASP3_XENLA 28.436 211 142 4 145 350 74 280 1.99E-18 87.4 CASP3_XENLA reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (xCPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] casp3 Xenopus laevis (African clawed frog) 282 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q08BD8 CHOYP_NEMVEDRAFT_V1G237042.2.2 m.16058 sp MTRF2_DANRE 32.558 129 74 3 21 147 207 324 1.99E-10 61.6 MTRF2_DANRE reviewed Mitochondrial fission regulator 2 mtfr2 fam54a zgc:153910 Danio rerio (Zebrafish) (Brachydanio rerio) 336 aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266] GO:0000266; GO:0005739; GO:0009060 0 0 0 PF05308; Q0UI56 CHOYP_BRAFLDRAFT_215208.1.1 m.40012 sp NBP35_PHANO 50.562 267 129 2 8 272 60 325 1.99E-89 272 NBP35_PHANO reviewed Cytosolic Fe-S cluster assembly factor NBP35 (Nucleotide-binding protein 35) NBP35 SNOG_08558 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) 340 iron-sulfur cluster assembly [GO:0016226] GO:0005524; GO:0005737; GO:0016226; GO:0046872; GO:0051539 0 0 cd02037; 0 Q13895 CHOYP_LOC100377066.1.2 m.18382 sp BYST_HUMAN 55.691 246 97 4 16 250 12 256 1.99E-86 266 BYST_HUMAN reviewed Bystin BYSL Homo sapiens (Human) 437 "brain development [GO:0007420]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to organic cyclic compound [GO:0071407]; female pregnancy [GO:0007565]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; neuron differentiation [GO:0030182]; rRNA processing [GO:0006364]; trophectodermal cell differentiation [GO:0001829]" GO:0000462; GO:0001829; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005881; GO:0006364; GO:0007155; GO:0007420; GO:0007565; GO:0008283; GO:0016020; GO:0030182; GO:0042995; GO:0043231; GO:0044822; GO:0045177; GO:0048471; GO:0071222; GO:0071347; GO:0071363; GO:0071407 0 0 0 PF05291; Q16QL3 CHOYP_COQ2.1.3 m.44533 sp COQ2_AEDAE 59.13 230 93 1 1 229 147 376 1.99E-96 291 COQ2_AEDAE reviewed "4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Coenzyme Q biosynthesis protein 2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)" coq2 AAEL011249 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 441 isoprenoid biosynthetic process [GO:0008299]; transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase I promoter [GO:0006360]; ubiquinone biosynthetic process [GO:0006744] GO:0002083; GO:0005666; GO:0005736; GO:0005743; GO:0006360; GO:0006383; GO:0006744; GO:0008299; GO:0008412; GO:0031305; GO:0047293 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03189}. 0 0 PF01040; Q25145 CHOYP_TPM.1.19 m.2309 sp TPM_HALRU 77.016 248 57 0 1 248 1 248 1.99E-120 347 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q2PC93 CHOYP_LOC100210677.3.8 m.4051 sp SSPO_CHICK 27.862 1651 878 54 14 1410 2578 4169 1.99E-115 406 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q2T9W3 CHOYP_BRAFLDRAFT_126033.1.1 m.50746 sp CCD63_BOVIN 29.182 538 367 6 21 551 28 558 1.99E-61 214 CCD63_BOVIN reviewed Coiled-coil domain-containing protein 63 CCDC63 Bos taurus (Bovine) 558 spermatid development [GO:0007286] GO:0007286 0 0 0 0 Q39565 CHOYP_LOC762758.1.1 m.51193 sp DYHB_CHLRE 26.684 1158 703 22 99 1184 407 1490 1.99E-118 418 DYHB_CHLRE reviewed "Dynein beta chain, flagellar outer arm" ODA4 ODA-4 SUP1 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4568 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0030030; GO:0030286; GO:0031514 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q3B725 CHOYP_BRAFLDRAFT_89152.1.1 m.7590 sp ZBT24_RAT 27.664 535 323 14 41 559 23 509 1.99E-39 158 ZBT24_RAT reviewed Zinc finger and BTB domain-containing protein 24 (Bone morphogenetic protein-induced factor 1) (Zinc finger protein 450) Zbtb24 Bif1 Znf450 Rattus norvegicus (Rat) 705 "hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0002244; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF00096;PF13912; Q3U0J8 CHOYP_BRAFLDRAFT_68841.1.1 m.7865 sp TBD2B_MOUSE 32.576 528 325 10 336 852 424 931 1.99E-68 254 TBD2B_MOUSE reviewed TBC1 domain family member 2B Tbc1d2b Kiaa1055 Mus musculus (Mouse) 965 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF00169;PF00566; Q5FVB2 CHOYP_LOC100368004.1.1 m.62584 sp LMO41_XENTR 60.69 145 56 1 25 168 8 152 1.99E-61 191 LMO41_XENTR reviewed LIM domain transcription factor LMO4.1 (LIM domain only protein 4.1) (LMO-4.1) lmo4.1 lmo4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 167 "gastrulation [GO:0007369]; mesoderm development [GO:0007498]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003712; GO:0006351; GO:0007369; GO:0007498; GO:0008270; GO:0045665; GO:0045944 0 0 0 PF00412; Q5R5L7 CHOYP_LOC100176335.3.7 m.29875 sp ARRD3_PONAB 28.346 254 134 9 4 254 179 387 1.99E-14 75.9 ARRD3_PONAB reviewed Arrestin domain-containing protein 3 ARRDC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 414 0 GO:0005764; GO:0005769; GO:0005886 0 0 0 PF02752;PF00339; Q5R9L3 CHOYP_BRAFLDRAFT_203026.1.1 m.61263 sp G3BP2_PONAB 43.813 493 229 11 1 462 1 476 1.99E-98 307 G3BP2_PONAB reviewed Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) G3BP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 482 mRNA transport [GO:0051028] GO:0000166; GO:0005737; GO:0044822; GO:0051028 0 0 cd00780; PF02136;PF00076; Q5XGG2 CHOYP_LOC100706557.1.1 m.45679 sp TRUB2_XENTR 33.846 195 124 2 215 409 100 289 1.99E-36 139 TRUB2_XENTR reviewed Probable tRNA pseudouridine synthase 2 (EC 5.4.99.-) trub2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 325 pseudouridine synthesis [GO:0001522]; tRNA processing [GO:0008033] GO:0001522; GO:0003723; GO:0008033; GO:0009982 0 0 0 PF01509; Q5ZIZ2 CHOYP_SMYD5.1.1 m.27234 sp SMYD5_CHICK 61.382 246 95 0 1 246 154 399 1.99E-111 330 SMYD5_CHICK reviewed SET and MYND domain-containing protein 5 (EC 2.1.1.-) SMYD5 RCJMB04_22j23 Gallus gallus (Chicken) 420 0 GO:0008168; GO:0046872 0 0 0 PF00856; Q5ZM73 CHOYP_BRAFLDRAFT_93126.3.3 m.31123 sp MIRO1_CHICK 46.479 142 70 2 4 143 476 613 1.99E-39 143 MIRO1_CHICK reviewed Mitochondrial Rho GTPase 1 (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1) RHOT1 RCJMB04_2p2 Gallus gallus (Chicken) 619 cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion transport along microtubule [GO:0047497]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005509; GO:0005525; GO:0007264; GO:0019725; GO:0031307; GO:0047497; GO:0097345 0 0 0 PF08355;PF08356;PF00071; Q62210 CHOYP_BRAFLDRAFT_117715.3.3 m.63008 sp BIRC2_MOUSE 26.812 276 163 8 311 580 370 612 1.99E-20 99 BIRC2_MOUSE reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (Inhibitor of apoptosis protein 2) (mIAP2) Birc2 Mus musculus (Mouse) 612 "inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0009898; GO:0016740; GO:0016874; GO:0034121; GO:0035631; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0060546; GO:0070266; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000377 0 0 0 PF00653;PF00619; Q69ZQ1 CHOYP_LOC100371381.1.2 m.6268 sp K1161_MOUSE 30.906 563 364 11 519 1070 155 703 1.99E-85 295 K1161_MOUSE reviewed Uncharacterized family 31 glucosidase KIAA1161 (EC 3.2.1.-) Kiaa1161 Mus musculus (Mouse) 716 carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of protein kinase B signaling [GO:0051897]; skeletal muscle fiber development [GO:0048741] GO:0004553; GO:0005975; GO:0016021; GO:0031965; GO:0043568; GO:0048741; GO:0051897 0 0 0 PF01055; Q6GLE1 CHOYP_PHUM_PHUM278110.1.1 m.17560 sp CCD25_XENTR 62.019 208 77 2 37 244 1 206 1.99E-87 260 CCD25_XENTR reviewed Coiled-coil domain-containing protein 25 ccdc25 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 206 0 0 0 0 0 PF05670; Q6IQX7 CHOYP_CHSS2.1.1 m.19314 sp CHSS2_MOUSE 32.304 777 472 19 7 745 10 770 1.99E-123 391 CHSS2_MOUSE reviewed Chondroitin sulfate synthase 2 (EC 2.4.1.175) (EC 2.4.1.226) (Chondroitin glucuronyltransferase 2) (Chondroitin-polymerizing factor) (ChPF) (Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II) (N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II) (N-acetylgalactosaminyltransferase 2) Chpf Css2 D1Bwg1363e Mus musculus (Mouse) 774 chondroitin sulfate biosynthetic process [GO:0030206] GO:0005759; GO:0005829; GO:0016021; GO:0016757; GO:0030206; GO:0032580; GO:0046872; GO:0047238; GO:0050510 0 0 0 PF05679; Q6PFY8 CHOYP_TRI45.22.23 m.62113 sp TRI45_MOUSE 30.653 199 118 5 11 197 129 319 1.99E-15 79.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6ZRF8 CHOYP_BRAFLDRAFT_82867.5.6 m.60886 sp RN207_HUMAN 21.608 199 136 8 16 211 103 284 1.99E-06 52.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8IUN9 CHOYP_BRAFLDRAFT_87395.1.1 m.44195 sp CLC10_HUMAN 32.203 177 98 8 273 438 143 308 1.99E-19 92 CLC10_HUMAN reviewed C-type lectin domain family 10 member A (C-type lectin superfamily member 14) (Macrophage lectin 2) (CD antigen CD301) CLEC10A CLECSF13 CLECSF14 HML Homo sapiens (Human) 316 adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; innate immune response [GO:0045087] GO:0002250; GO:0005886; GO:0006897; GO:0016021; GO:0030246; GO:0045087 0 0 0 PF00059;PF03954; Q8IVG5 CHOYP_BRAFLDRAFT_131039.6.9 m.53486 sp SAM9L_HUMAN 28.024 339 198 17 734 1046 682 1000 1.99E-14 83.2 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8K2R5 CHOYP_ZN184.1.4 m.1091 sp ZN668_MOUSE 26.108 406 231 16 89 450 18 398 1.99E-23 107 ZN668_MOUSE reviewed Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q8TEW0 CHOYP_PARD3.1.1 m.22873 sp PARD3_HUMAN 39.785 744 367 21 3 725 1 684 1.99E-126 431 PARD3_HUMAN reviewed Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) 1356 asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell cycle [GO:0007049]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein complex assembly [GO:0006461]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein targeting to membrane [GO:0006612]; regulation of cellular localization [GO:0060341]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005546; GO:0005547; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005923; GO:0005938; GO:0006461; GO:0006612; GO:0007049; GO:0007163; GO:0007179; GO:0007205; GO:0007409; GO:0008356; GO:0010801; GO:0012505; GO:0022011; GO:0030054; GO:0031643; GO:0032266; GO:0033269; GO:0043025; GO:0043234; GO:0044295; GO:0060341; GO:0070830; GO:0090162 0 0 0 PF12053;PF00595; Q96LX7 CHOYP_LOC100495562.2.2 m.30691 sp CCD17_HUMAN 25 328 167 12 8 280 13 316 1.99E-14 78.6 CCD17_HUMAN reviewed Coiled-coil domain-containing protein 17 CCDC17 Homo sapiens (Human) 622 0 0 0 0 0 0 Q96PQ7 CHOYP_R12E2.1.1.1 m.48454 sp KLHL5_HUMAN 26.29 620 396 18 370 986 181 742 1.99E-53 203 KLHL5_HUMAN reviewed Kelch-like protein 5 KLHL5 Homo sapiens (Human) 755 protein ubiquitination [GO:0016567] GO:0005737; GO:0005856; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q96QF0 CHOYP_BRAFLDRAFT_199346.2.3 m.52978 sp RAB3I_HUMAN 46.547 333 145 5 111 431 160 471 1.99E-90 285 RAB3I_HUMAN reviewed Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein) RAB3IP RABIN8 Homo sapiens (Human) 476 cilium assembly [GO:0042384]; Golgi to plasma membrane transport [GO:0006893]; protein localization to organelle [GO:0033365]; protein targeting to membrane [GO:0006612] GO:0005634; GO:0005813; GO:0005829; GO:0005856; GO:0006612; GO:0006893; GO:0017112; GO:0030027; GO:0033365; GO:0036064; GO:0042384 0 0 0 PF06428; Q96RW7 CHOYP_LOC101236385.6.6 m.65447 sp HMCN1_HUMAN 44.744 371 201 1 511 881 4503 4869 1.99E-97 349 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99N01 CHOYP_SLCO4A1.3.4 m.41748 sp SO4A1_RAT 37.805 410 245 6 18 426 90 490 1.99E-85 279 SO4A1_RAT reviewed Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Rattus norvegicus (Rat) 723 sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403] GO:0005887; GO:0015347; GO:0015349; GO:0042403; GO:0043252 0 0 cd06174; PF07648;PF03137; Q9BYV1 CHOYP_TRIADDRAFT_63204.2.2 m.38038 sp AGT2_HUMAN 59.272 302 121 2 1 301 205 505 1.99E-132 389 AGT2_HUMAN reviewed "Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferase) (D-AIBAT)" AGXT2 AGT2 Homo sapiens (Human) 514 "glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; L-alanine catabolic process, by transamination [GO:0019481]; positive regulation of nitric oxide biosynthetic process [GO:0045429]" GO:0005739; GO:0005759; GO:0008453; GO:0009436; GO:0016223; GO:0019265; GO:0019481; GO:0030170; GO:0042802; GO:0045429; GO:0046487; GO:0047305 0 0 cd00610; PF00202; Q9CWH6 CHOYP_BRAFLDRAFT_279789.2.3 m.43202 sp PSA7L_MOUSE 77.912 249 54 1 39 287 1 248 1.99E-144 408 PSA7L_MOUSE reviewed Proteasome subunit alpha type-7-like (EC 3.4.25.1) Psma8 Psma7l Mus musculus (Mouse) 250 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0002479; GO:0004298; GO:0005634; GO:0005829; GO:0006511; GO:0019773; GO:0070062; GO:1990111 0 0 0 PF00227;PF10584; Q9D531 CHOYP_LOC100917229.1.1 m.9078 sp NXNL2_MOUSE 41.481 135 75 2 59 190 17 150 1.99E-36 128 NXNL2_MOUSE reviewed Nucleoredoxin-like protein 2 (Rod-derived cone viability factor 2) (RdCVF2) Nxnl2 Mus musculus (Mouse) 156 photoreceptor cell maintenance [GO:0045494]; sensory perception of smell [GO:0007608]; visual perception [GO:0007601] GO:0007601; GO:0007608; GO:0045494 0 0 0 PF13905; Q9HB96 CHOYP_LOC100028417.1.1 m.18144 sp FANCE_HUMAN 21.586 227 172 3 237 459 310 534 1.99E-09 63.5 FANCE_HUMAN reviewed Fanconi anemia group E protein (Protein FACE) FANCE FACE Homo sapiens (Human) 536 interstrand cross-link repair [GO:0036297] GO:0005634; GO:0005654; GO:0036297; GO:0043240 0 0 0 PF11510; Q9HBM0 CHOYP_VEZT.2.3 m.36326 sp VEZA_HUMAN 28.302 371 207 15 1 346 425 761 1.99E-13 75.1 VEZA_HUMAN reviewed Vezatin VEZT Homo sapiens (Human) 779 single organismal cell-cell adhesion [GO:0016337] GO:0001669; GO:0005654; GO:0005737; GO:0005886; GO:0005912; GO:0016021; GO:0016337 0 0 0 PF12632; Q9MA55 CHOYP_LOC100376506.1.1 m.55776 sp ACBP4_ARATH 33.684 285 154 10 293 564 166 428 1.99E-34 142 ACBP4_ARATH reviewed Acyl-CoA-binding domain-containing protein 4 (Acyl-CoA binding protein 4) ACBP4 At3g05420 F22F7.13 Arabidopsis thaliana (Mouse-ear cress) 668 lipid transport [GO:0006869]; response to ethylene [GO:0009723]; response to jasmonic acid [GO:0009753]; response to light stimulus [GO:0009416]; transport [GO:0006810] GO:0000062; GO:0005634; GO:0005737; GO:0005829; GO:0006810; GO:0006869; GO:0008289; GO:0009416; GO:0009723; GO:0009753 0 0 0 PF00887; Q9ULJ7 CHOYP_LOC100889142.1.4 m.39975 sp ANR50_HUMAN 33.157 567 350 19 814 1357 529 1089 1.99E-58 225 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A0JM12 CHOYP_MEG10.77.91 m.58581 sp MEG10_XENTR 32.342 1076 606 16 5 982 6 1057 2.00E-162 509 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AV25 CHOYP_BRAFLDRAFT_86061.5.13 m.43002 sp FBCD1_MOUSE 49.302 215 99 3 37 241 239 453 2.00E-71 228 FBCD1_MOUSE reviewed Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) 459 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; A4IF63 CHOYP_NAEGRDRAFT_70324.1.2 m.28139 sp TRIM2_BOVIN 30 120 79 3 54 170 627 744 2.00E-08 55.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B3EWY9 CHOYP_contig_045992 m.53728 sp MLP_ACRMI 29.336 1084 607 33 114 1137 390 1374 2.00E-112 399 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B7Z6K7 CHOYP_LOC100148223.1.1 m.10633 sp ZN814_HUMAN 30.631 444 243 17 311 719 237 650 2.00E-40 164 ZN814_HUMAN reviewed Putative uncharacterized zinc finger protein 814 (Putative zinc finger protein LOC730051) ZNF814 Homo sapiens (Human) 855 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003676; GO:0003700; GO:0005622; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; O01761 CHOYP_CRE-UNC-89.3.3 m.61234 sp UNC89_CAEEL 25.496 353 208 15 244 570 4542 4865 2.00E-09 65.9 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O02739 CHOYP_LOC100136251.1.1 m.58607 sp SPB6_BOVIN 40.369 379 211 7 36 402 3 378 2.00E-88 275 SPB6_BOVIN reviewed Serpin B6 (Proteinase inhibitor 6) (Serine proteinase inhibitor B-43) SERPINB6 Bos taurus (Bovine) 378 0 GO:0004867; GO:0005615; GO:0005737 0 0 0 PF00079; O16305 CHOYP_CALM.17.50 m.30486 sp CALM_CAEEL 62.416 149 56 0 1 149 1 149 2.00E-65 199 CALM_CAEEL reviewed Calmodulin (CaM) cmd-1 T21H3.3 Caenorhabditis elegans 149 apoptotic cell clearance [GO:0043277]; cell migration [GO:0016477]; embryo development ending in birth or egg hatching [GO:0009792]; establishment of meiotic spindle orientation [GO:0051296]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880] GO:0005509; GO:0005813; GO:0009792; GO:0016477; GO:0031965; GO:0032880; GO:0042981; GO:0043277; GO:0051296; GO:0051726; GO:0071944; GO:0072686 0 0 0 PF13499; O16305 CHOYP_CALM.26.50 m.35903 sp CALM_CAEEL 62.416 149 56 0 1 149 1 149 2.00E-65 199 CALM_CAEEL reviewed Calmodulin (CaM) cmd-1 T21H3.3 Caenorhabditis elegans 149 apoptotic cell clearance [GO:0043277]; cell migration [GO:0016477]; embryo development ending in birth or egg hatching [GO:0009792]; establishment of meiotic spindle orientation [GO:0051296]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880] GO:0005509; GO:0005813; GO:0009792; GO:0016477; GO:0031965; GO:0032880; GO:0042981; GO:0043277; GO:0051296; GO:0051726; GO:0071944; GO:0072686 0 0 0 PF13499; O17966 CHOYP_BRAFLDRAFT_273832.1.1 m.56326 sp TOP1_CAEEL 37.7 313 130 3 57 304 482 794 2.00E-59 206 TOP1_CAEEL reviewed DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) (topoI) top-1 M01E5.5 Caenorhabditis elegans 806 chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260]; DNA topological change [GO:0006265] GO:0003677; GO:0003917; GO:0003918; GO:0005634; GO:0005730; GO:0006260; GO:0006265; GO:0006338; GO:0007059; GO:0031298; GO:0031616 0 0 0 PF14370;PF01028;PF02919; O44252 CHOYP_DYAK_GE10665.1.1 m.34866 sp ROST_DROME 25.984 254 162 8 28 260 8 256 2.00E-19 89.4 ROST_DROME reviewed Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) 275 myoblast fusion [GO:0007520]; skeletal muscle tissue development [GO:0007519] GO:0007519; GO:0007520; GO:0016020; GO:0016021 0 0 0 0 O51741 CHOYP_contig_054999 m.65622 sp IF2_BORBU 29.252 147 102 2 2 146 69 215 2.00E-09 61.2 IF2_BORBU reviewed Translation initiation factor IF-2 infB BB_0801 Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) 882 0 GO:0003743; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF11987;PF04760; O75179 CHOYP_LOC754728.4.6 m.41549 sp ANR17_HUMAN 32.627 236 147 6 15 238 1120 1355 2.00E-26 110 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P04069 CHOYP_LOC100870142.1.1 m.37849 sp CBPB_ASTAS 50.336 149 73 1 2 150 143 290 2.00E-47 158 CBPB_ASTAS reviewed Carboxypeptidase B (EC 3.4.17.2) 0 Astacus astacus (Noble crayfish) (Astacus fluviatilis) 303 0 GO:0004181; GO:0005576; GO:0008270 0 0 0 PF00246; P04113 CHOYP_BRAFLDRAFT_75725.1.1 m.9605 sp MLRA_MIZYE 75.439 114 28 0 1 114 48 161 2.00E-55 172 MLRA_MIZYE reviewed "Myosin regulatory light chain A, smooth adductor muscle" 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 161 0 GO:0005509; GO:0016459 0 0 0 PF13405; P11118 CHOYP_CALM.24.50 m.32079 sp CALM_EUGGR 45.098 102 53 1 3 104 48 146 2.00E-21 85.9 CALM_EUGGR reviewed Calmodulin (CaM) 0 Euglena gracilis 149 0 GO:0005509 0 0 0 PF13499; P11714 CHOYP_CP2D9.2.2 m.31468 sp CP2D9_MOUSE 30.435 506 324 10 6 497 9 500 2.00E-63 217 CP2D9_MOUSE reviewed Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (Cytochrome P450-16-alpha) (Cytochrome P450CA) (Testosterone 16-alpha hydroxylase) Cyp2d9 Cyp2d-9 Mus musculus (Mouse) 504 arachidonic acid metabolic process [GO:0019369] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019369; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P16157 CHOYP_TVAG_067900.1.7 m.912 sp ANK1_HUMAN 38.136 236 146 0 1 236 229 464 2.00E-42 157 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22105 CHOYP_AGAP_AGAP001390.1.2 m.38986 sp TENX_HUMAN 27.957 186 88 8 80 231 407 580 2.00E-07 57.4 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P24014 CHOYP_SLIT1.4.5 m.45166 sp SLIT_DROME 30.097 206 113 3 17 197 739 938 2.00E-22 105 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P25169 CHOYP_LOC100698842.1.1 m.40945 sp AT1B1_ARTSF 27.111 225 128 6 112 319 91 296 2.00E-17 85.1 AT1B1_ARTSF reviewed Sodium/potassium-transporting ATPase subunit beta (Sodium/potassium-dependent ATPase beta subunit) 0 Artemia franciscana (Brine shrimp) (Artemia sanfranciscana) 315 potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] GO:0005890; GO:0006813; GO:0006814 0 0 0 PF00287; P27485 CHOYP_LOC584238.1.1 m.30307 sp RET4_PIG 24.873 197 127 7 10 204 6 183 2.00E-07 53.1 RET4_PIG reviewed Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) RBP4 Sus scrofa (Pig) 201 0 GO:0005215; GO:0005576; GO:0016918; GO:0019841 0 0 0 PF00061; P49109 CHOYP_MGC81930.1.1 m.10298 sp FMO5_CAVPO 42.885 513 269 7 28 527 1 502 2.00E-140 420 FMO5_CAVPO reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; P92182 CHOYP_CRE_00778.1.1 m.49411 sp ACT1_LUMTE 98.734 79 1 0 1 79 133 211 2.00E-48 161 ACT1_LUMTE reviewed Actin-1 ACT1 Lumbricus terrestris (Common earthworm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q00971 CHOYP_contig_038919 m.44078 sp NPRV_VIBPR 35.854 357 213 8 1 350 210 557 2.00E-64 218 NPRV_VIBPR reviewed Neutral protease (EC 3.4.24.25) (Aeromonolysin) (Vibriolysin) nprV Vibrio proteolyticus (Aeromonas proteolytica) 609 0 GO:0004222; GO:0005576; GO:0046872 0 0 0 PF07504;PF03413;PF01447;PF02868;PF04151; Q09139 CHOYP_FABP7.2.2 m.29096 sp FABP7_BOVIN 31.618 136 88 3 4 139 2 132 2.00E-13 65.9 FABP7_BOVIN reviewed "Fatty acid-binding protein, brain (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7)" FABP7 Bos taurus (Bovine) 132 cell proliferation in forebrain [GO:0021846]; neurogenesis [GO:0022008]; prepulse inhibition [GO:0060134] GO:0005215; GO:0005654; GO:0005737; GO:0005911; GO:0008289; GO:0021846; GO:0022008; GO:0042995; GO:0043025; GO:0060134; GO:0071944 0 0 0 PF00061; Q26636 CHOYP_AAEL_AAEL002833.1.1 m.64288 sp CATL_SARPE 54.576 295 127 2 53 340 25 319 2.00E-114 339 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q3T0B7 CHOYP_RS27L.1.4 m.9354 sp RS27L_BOVIN 90.476 84 8 0 21 104 1 84 2.00E-49 154 RS27L_BOVIN reviewed 40S ribosomal protein S27-like RPS27L Bos taurus (Bovine) 84 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627; GO:0046872 0 0 0 PF01667; Q3T142 CHOYP_MRPL45.1.1 m.11763 sp RM45_BOVIN 38.208 212 121 3 106 313 74 279 2.00E-45 161 RM45_BOVIN reviewed "39S ribosomal protein L45, mitochondrial (L45mt) (MRP-L45)" MRPL45 Bos taurus (Bovine) 306 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0005739; GO:0005743; GO:0005840; GO:0070124; GO:0070125 0 0 0 PF04280; Q49MI3 CHOYP_CERKL.1.4 m.18324 sp CERKL_HUMAN 29.213 445 250 6 83 501 95 500 2.00E-61 218 CERKL_HUMAN reviewed Ceramide kinase-like protein CERKL Homo sapiens (Human) 558 negative regulation of apoptotic process [GO:0043066] GO:0005730; GO:0005737; GO:0005783; GO:0005794; GO:0016301; GO:0043066 0 0 0 PF00781; Q56R14 CHOYP_BRAFLDRAFT_85511.23.23 m.66423 sp TRI33_XENLA 27.509 269 168 8 11 264 92 348 2.00E-18 90.9 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5F389 CHOYP_WWOX.1.1 m.65935 sp WWOX_CHICK 55.409 379 167 1 34 410 33 411 2.00E-158 456 WWOX_CHICK reviewed WW domain-containing oxidoreductase (EC 1.1.1.-) WWOX RCJMB04_28b1 Gallus gallus (Chicken) 414 apoptotic process [GO:0006915]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005737; GO:0006915; GO:0016055; GO:0016491 0 0 0 PF00106;PF00397; Q5FWT1 CHOYP_LOC100372505.1.2 m.10260 sp FA98A_RAT 49.405 336 158 4 1 333 6 332 2.00E-93 293 FA98A_RAT reviewed Protein FAM98A Fam98a Rattus norvegicus (Rat) 515 0 GO:0044822; GO:0072669 0 0 0 PF10239; Q5ND28 CHOYP_LOC763793.6.7 m.38375 sp SREC_MOUSE 36.458 192 113 7 185 376 213 395 2.00E-22 103 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RAS7 CHOYP_PHUM_PHUM577920.1.1 m.5207 sp AMMR1_PONAB 68.912 193 60 0 69 261 125 317 2.00E-98 294 AMMR1_PONAB reviewed AMME syndrome candidate gene 1 protein homolog AMMECR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 333 0 0 0 0 0 PF01871; Q5RGJ8 CHOYP_GNPTA.2.3 m.39603 sp GNPTA_DANRE 41.413 722 339 14 14 661 505 1216 2.00E-167 514 GNPTA_DANRE reviewed N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein gnptab) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] gnptab gnpta si:ch211-234f20.3 zgc:122985 Danio rerio (Zebrafish) (Brachydanio rerio) 1219 carbohydrate phosphorylation [GO:0046835]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256] GO:0000139; GO:0002063; GO:0003976; GO:0005509; GO:0005794; GO:0007040; GO:0016021; GO:0016256; GO:0046835; GO:0048701; GO:0048703; GO:0051216 0 0 0 PF06464;PF00066;PF17101;PF11380;PF17102;PF17103; Q5ZHY5 CHOYP_PHUM_PHUM234540.1.1 m.9211 sp CHIP_CHICK 58.214 280 114 1 2 278 35 314 2.00E-118 345 CHIP_CHICK reviewed STIP1 homology and U box-containing protein 1 (EC 6.3.2.-) STUB1 RCJMB04_32b21 Gallus gallus (Chicken) 314 cellular response to misfolded protein [GO:0071218]; DNA repair [GO:0006281]; endoplasmic reticulum unfolded protein response [GO:0030968]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; negative regulation of protein binding [GO:0032091]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of glucocorticoid metabolic process [GO:0031943]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent SMAD protein catabolic process [GO:0030579] GO:0000151; GO:0000209; GO:0004842; GO:0005654; GO:0005783; GO:0005886; GO:0006281; GO:0006511; GO:0006515; GO:0016874; GO:0030018; GO:0030579; GO:0030968; GO:0031647; GO:0031943; GO:0032091; GO:0032436; GO:0034450; GO:0042405; GO:0042787; GO:0042803; GO:0043161; GO:0045111; GO:0051443; GO:0051865; GO:0070062; GO:0070534; GO:0071218; GO:0090035; GO:1904264 0 0 0 PF04564; Q61830 CHOYP_LOC101242123.1.1 m.66679 sp MRC1_MOUSE 31.818 110 62 5 36 143 1243 1341 2.00E-07 52.8 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q61830 CHOYP_LOC586122.1.4 m.4594 sp MRC1_MOUSE 31.818 110 62 5 36 143 1243 1341 2.00E-07 52.8 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q80X08 CHOYP_LOC659226.2.3 m.60473 sp FAM21_RAT 28.54 459 216 17 47 470 941 1322 2.00E-19 95.5 FAM21_RAT reviewed WASH complex subunit FAM21 Fam21 Rattus norvegicus (Rat) 1328 "retrograde transport, endosome to Golgi [GO:0042147]" GO:0005769; GO:0005829; GO:0005886; GO:0031901; GO:0042147; GO:0071203 0 0 0 PF15255; Q86VQ0 CHOYP_LCA5.1.1 m.10197 sp LCA5_HUMAN 40 225 132 1 44 265 77 301 2.00E-36 150 LCA5_HUMAN reviewed Lebercilin (Leber congenital amaurosis 5 protein) LCA5 C6orf152 Homo sapiens (Human) 697 protein transport [GO:0015031] GO:0005737; GO:0005815; GO:0005929; GO:0015031; GO:0032403 0 0 0 PF15619; Q8BTU1 CHOYP_CP080.1.1 m.24911 sp CFA20_MOUSE 99.479 192 1 0 94 285 1 192 2.00E-141 398 CFA20_MOUSE reviewed Cilia- and flagella-associated protein 20 (Gene trap locus 3 protein) Cfap20 Gtl3 Mus musculus (Mouse) 193 cilium morphogenesis [GO:0060271]; positive regulation of cell motility [GO:2000147]; positive regulation of feeding behavior [GO:2000253]; protein polyglutamylation [GO:0018095]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296] GO:0005654; GO:0005814; GO:0005874; GO:0005929; GO:0018095; GO:0036064; GO:0044822; GO:0060271; GO:0060296; GO:0070062; GO:2000147; GO:2000253 0 0 0 PF05018; Q8BYI6 CHOYP_LPCAT2.1.1 m.45227 sp PCAT2_MOUSE 51.196 418 199 4 4 419 92 506 2.00E-151 443 PCAT2_MOUSE reviewed Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) Lpcat2 Aytl1 Aytl1a Lpcat2a Mus musculus (Mouse) 544 membrane organization [GO:0061024]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; platelet activating factor biosynthetic process [GO:0006663] GO:0000139; GO:0003841; GO:0005509; GO:0005783; GO:0005789; GO:0005795; GO:0005811; GO:0006663; GO:0016021; GO:0036151; GO:0047184; GO:0047192; GO:0061024 PATHWAY: Lipid metabolism; phospholipid metabolism. 0 0 PF01553;PF13499; Q8C525 CHOYP_LOC100254784.1.1 m.56238 sp M21D2_MOUSE 25.137 183 129 5 553 729 173 353 2.00E-06 55.1 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8CGN4 CHOYP_BCOR.1.1 m.60678 sp BCOR_MOUSE 42.435 271 141 4 1209 1467 1444 1711 2.00E-52 207 BCOR_MOUSE reviewed BCL-6 corepressor (BCoR) Bcor Kiaa1575 Mus musculus (Mouse) 1759 "heart development [GO:0007507]; histone H2A monoubiquitination [GO:0035518]; negative regulation of bone mineralization [GO:0030502]; negative regulation of histone H3-K36 methylation [GO:0000415]; negative regulation of histone H3-K4 methylation [GO:0051572]; negative regulation of tooth mineralization [GO:0070171]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; odontogenesis [GO:0042476]; palate development [GO:0060021]; specification of axis polarity [GO:0065001]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000415; GO:0003714; GO:0004842; GO:0005634; GO:0005739; GO:0006351; GO:0007507; GO:0008134; GO:0030502; GO:0031072; GO:0031519; GO:0035518; GO:0042476; GO:0042826; GO:0044212; GO:0045892; GO:0051572; GO:0060021; GO:0065001; GO:0070171 0 0 0 PF12796;PF15808;PF16553; Q8IZR5 CHOYP_CKLF4.1.1 m.55295 sp CKLF4_HUMAN 32.24 183 114 6 2 178 24 202 2.00E-14 72 CKLF4_HUMAN reviewed CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4) CMTM4 CKLFSF4 Homo sapiens (Human) 234 chemotaxis [GO:0006935] GO:0005615; GO:0006935; GO:0016021 0 0 0 PF01284; Q8JHV9 CHOYP_LOC100912369.1.1 m.26619 sp BIR7A_XENLA 28.235 340 162 7 25 360 139 400 2.00E-38 144 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8RA32 CHOYP_LOC100568867.2.2 m.35043 sp DPO3_CALS4 31.868 182 97 7 555 730 383 543 2.00E-12 75.1 DPO3_CALS4 reviewed DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC TTE1398 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) 1401 DNA-dependent DNA replication [GO:0006261] GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 0 0 0 PF11490;PF07733;PF14579;PF02811;PF00929; Q95JR3 CHOYP_LOC100690848.1.1 m.1375 sp SRAC1_MACFA 39.597 149 86 2 101 245 135 283 2.00E-29 118 SRAC1_MACFA reviewed Protein SERAC1 (Serine active site-containing protein 1) SERAC1 QtsA-14245 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 531 phospholipid biosynthetic process [GO:0008654] GO:0005739; GO:0005783; GO:0008654; GO:0016021 0 0 0 0 Q99315 CHOYP_contig_044846 m.52015 sp YG31B_YEAST 31.124 694 428 16 481 1142 636 1311 2.00E-87 317 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q99417 CHOYP_BRAFLDRAFT_115113.2.2 m.41358 sp MYCBP_HUMAN 65.957 94 32 0 33 126 1 94 2.00E-40 133 MYCBP_HUMAN reviewed C-Myc-binding protein (Associate of Myc 1) (AMY-1) MYCBP AMY1 Homo sapiens (Human) 103 "regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005737; GO:0005739; GO:0006351; GO:0006355; GO:0007283 0 0 0 0 Q9BVR0 CHOYP_BRAFLDRAFT_120990.15.18 m.60937 sp HRC23_HUMAN 49.02 51 24 1 303 351 594 644 2.00E-07 58.2 HRC23_HUMAN reviewed Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) 1158 0 GO:0004842; GO:0046872 0 0 0 PF06701; Q9GZT9 CHOYP_EGLN1.1.1 m.65426 sp EGLN1_HUMAN 42.336 411 210 7 17 423 21 408 2.00E-103 316 EGLN1_HUMAN reviewed Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) EGLN1 C1orf12 PNAS-118 PNAS-137 Homo sapiens (Human) 426 cardiac muscle tissue morphogenesis [GO:0055008]; heart trabecula formation [GO:0060347]; labyrinthine layer development [GO:0060711]; negative regulation of cAMP catabolic process [GO:0030821]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; oxygen homeostasis [GO:0032364]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; regulation of angiogenesis [GO:0045765]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731]; ventricular septum morphogenesis [GO:0060412] GO:0001666; GO:0005506; GO:0005634; GO:0005737; GO:0005829; GO:0016706; GO:0018401; GO:0019899; GO:0030821; GO:0031418; GO:0031543; GO:0031545; GO:0032364; GO:0043433; GO:0045765; GO:0051344; GO:0055008; GO:0060347; GO:0060412; GO:0060711; GO:0061418; GO:0071731 0 0 0 PF13640;PF01753; Q9NWZ3 CHOYP_PHUM_PHUM430580.1.1 m.61592 sp IRAK4_HUMAN 39.08 174 102 2 1 172 288 459 2.00E-30 118 IRAK4_HUMAN reviewed Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64) IRAK4 Homo sapiens (Human) 460 cytokine-mediated signaling pathway [GO:0019221]; cytokine production [GO:0001816]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil mediated immunity [GO:0002446]; neutrophil migration [GO:1990266]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of smooth muscle cell proliferation [GO:0048661]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] GO:0000287; GO:0001816; GO:0002224; GO:0002446; GO:0002755; GO:0004672; GO:0004674; GO:0005524; GO:0005615; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007254; GO:0010008; GO:0019221; GO:0034162; GO:0043123; GO:0045087; GO:0048661; GO:1990266 0 0 0 PF07714; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G247395.4.8 m.26820 sp SACS_HUMAN 21.784 1166 711 42 102 1124 3466 4573 2.00E-43 177 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9VZF4 CHOYP_LOC579989.1.1 m.27403 sp FBXW7_DROME 28.387 465 287 14 161 599 825 1269 2.00E-48 187 FBXW7_DROME reviewed F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago) ago CG15010 Drosophila melanogaster (Fruit fly) 1326 "axon guidance [GO:0007411]; branch fusion, open tracheal system [GO:0035147]; cellular response to hypoxia [GO:0071456]; DNA endoreduplication [GO:0042023]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of growth [GO:0045926]; protein ubiquitination [GO:0016567]; regulation of exit from mitosis [GO:0007096]; regulation of mitophagy [GO:1903146]; regulation of mitotic nuclear division [GO:0007088]; regulation of proteolysis [GO:0030162]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; trachea development [GO:0060438]; ventral cord development [GO:0007419]" GO:0005634; GO:0007088; GO:0007096; GO:0007411; GO:0007419; GO:0008054; GO:0016567; GO:0019005; GO:0030162; GO:0030332; GO:0031146; GO:0035147; GO:0042023; GO:0045926; GO:0060253; GO:0060438; GO:0071456; GO:1900038; GO:1903146 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9W5U2 CHOYP_DWIL_GK17254.1.1 m.11794 sp CHIT3_DROME 27.536 207 125 7 3 200 658 848 2.00E-08 57 CHIT3_DROME reviewed Probable chitinase 3 (EC 3.2.1.14) (Probable chitinase 1) Cht3 Cht1 CG18140 Drosophila melanogaster (Fruit fly) 2286 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0006032; GO:0008061 0 0 0 PF01607;PF00704; A1A5X5 CHOYP_F132A.1.1 m.62831 sp ADIPL_DANRE 40.484 289 149 7 37 319 46 317 2.01E-49 170 ADIPL_DANRE reviewed Adipolin (Adipose-derived insulin-sensitizing factor) (Complement C1q tumor necrosis factor-related protein 12) fam132a c1qdc2 zgc:158358 Danio rerio (Zebrafish) (Brachydanio rerio) 318 multicellular organism development [GO:0007275]; regulation of glucose import [GO:0046324]; Wnt signaling pathway [GO:0016055] GO:0005179; GO:0005576; GO:0007275; GO:0016055; GO:0046324 0 0 0 PF00386; A6NDG6 CHOYP_BRAFLDRAFT_128828.2.2 m.34173 sp PGP_HUMAN 35.354 198 126 1 6 203 120 315 2.01E-40 143 PGP_HUMAN reviewed Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) PGP Homo sapiens (Human) 321 dephosphorylation [GO:0016311]; glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721]; peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0000121; GO:0000287; GO:0004721; GO:0004725; GO:0005829; GO:0006114; GO:0006650; GO:0008967; GO:0016311; GO:0035335; GO:0043136; GO:0045721; GO:0098519 0 0 0 PF13344; B0S8I0 CHOYP_GTPB8.1.1 m.14143 sp GTPB8_DANRE 43.983 241 134 1 42 282 47 286 2.01E-58 191 GTPB8_DANRE reviewed GTP-binding protein 8 gtpbp8 si:rp71-84d19.3 Danio rerio (Zebrafish) (Brachydanio rerio) 286 0 GO:0003924; GO:0005525; GO:0005739; GO:0046872 0 0 0 PF01926; B3EWY9 CHOYP_contig_054140 m.64681 sp MLP_ACRMI 27.809 1068 618 38 824 1828 388 1365 2.01E-97 353 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B4JTF5 CHOYP_LOC100366797.2.3 m.54046 sp HH_DROGR 33.588 131 54 3 497 624 116 216 2.01E-06 56.2 HH_DROGR reviewed Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product] hh GH23852 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) 479 anatomical structure morphogenesis [GO:0009653]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; segment polarity determination [GO:0007367] GO:0005615; GO:0005634; GO:0005737; GO:0005886; GO:0007367; GO:0008233; GO:0009653; GO:0016015; GO:0016539; GO:0045168; GO:0046872 0 0 0 PF01085;PF01079; D3YXG0 CHOYP_DMOJ_GI18925.1.1 m.37775 sp HMCN1_MOUSE 27.81 525 301 32 24 503 772 1263 2.01E-20 101 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D3YXG0 CHOYP_HMCN1.29.44 m.50975 sp HMCN1_MOUSE 21.157 553 373 17 5 515 1753 2284 2.01E-19 96.7 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E1BD59 CHOYP_BRAFLDRAFT_99625.1.1 m.17254 sp TRI56_BOVIN 21.549 297 202 5 18 301 20 298 2.01E-11 70.9 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; P00920 CHOYP_BRAFLDRAFT_127510.1.1 m.48935 sp CAH2_MOUSE 37.453 267 154 7 33 297 5 260 2.01E-56 187 CAH2_MOUSE reviewed Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) Ca2 Car2 Mus musculus (Mouse) 260 "angiotensin-activated signaling pathway [GO:0038166]; carbon dioxide transport [GO:0015670]; cellular response to fluid shear stress [GO:0071498]; kidney development [GO:0001822]; morphogenesis of an epithelium [GO:0002009]; odontogenesis of dentin-containing tooth [GO:0042475]; one-carbon metabolic process [GO:0006730]; positive regulation of bone resorption [GO:0045780]; positive regulation of cellular pH reduction [GO:0032849]; positive regulation of dipeptide transmembrane transport [GO:2001150]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of anion transport [GO:0044070]; regulation of chloride transport [GO:2001225]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; response to estrogen [GO:0043627]; response to pH [GO:0009268]; response to steroid hormone [GO:0048545]; response to zinc ion [GO:0010043]; secretion [GO:0046903]" GO:0001822; GO:0002009; GO:0004064; GO:0004089; GO:0005615; GO:0005737; GO:0005829; GO:0005886; GO:0005902; GO:0006730; GO:0006885; GO:0008270; GO:0009268; GO:0010043; GO:0015670; GO:0016323; GO:0030424; GO:0032230; GO:0032849; GO:0038166; GO:0042475; GO:0043209; GO:0043627; GO:0044070; GO:0045177; GO:0045672; GO:0045780; GO:0046903; GO:0048545; GO:0051453; GO:0070062; GO:0071498; GO:2001150; GO:2001225 0 0 0 PF00194; P0DH96 CHOYP_CML1.1.1 m.30763 sp CALM4_ARATH 35.172 145 93 1 14 158 5 148 2.01E-23 92.8 CALM4_ARATH reviewed Calmodulin-4 (CaM-4) CAM4 At1g66410 F28G11.13 T27F4.1 Arabidopsis thaliana (Mouse-ear cress) 149 0 GO:0005509 0 0 0 PF13499; P22451 CHOYP_LOC100186763.1.2 m.3465 sp RL5_CHICK 66.667 45 15 0 20 64 203 247 2.01E-13 68.6 RL5_CHICK reviewed 60S ribosomal protein L5 RPL5 Gallus gallus (Chicken) 297 ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0005925; GO:0006364; GO:0006412; GO:0008097; GO:0016020; GO:0022625; GO:0044822; GO:0070062 0 0 0 PF14204;PF17144; P49180 CHOYP_LOC100909312.1.1 m.29209 sp RL35A_CAEEL 62.069 58 22 0 15 72 57 114 2.01E-17 77 RL35A_CAEEL reviewed 60S ribosomal protein L35a rpl-33 F10E7.7 Caenorhabditis elegans 124 cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273] GO:0002181; GO:0003735; GO:0022625; GO:0042273 0 0 0 PF01247; P95896 CHOYP_BRAFLDRAFT_94568.2.2 m.49174 sp AMID_SULSO 48.12 399 202 3 1 395 106 503 2.01E-126 377 AMID_SULSO reviewed Amidase (EC 3.5.1.4) SSO2122 C02016 C02_017 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 504 0 GO:0004040; GO:0016884 0 0 0 PF01425; Q01768 CHOYP_AGAP_AGAP007120.1.1 m.57542 sp NDKB_MOUSE 70.199 151 45 0 18 168 2 152 2.01E-78 233 NDKB_MOUSE reviewed Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (Histidine protein kinase NDKB) (EC 2.7.13.3) (P18) (nm23-M2) Nme2 Mus musculus (Mouse) 152 CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of apoptotic process [GO:0043066]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; regulation of apoptotic process [GO:0042981]; regulation of epidermis development [GO:0045682]; UTP biosynthetic process [GO:0006228] GO:0001726; GO:0004550; GO:0004673; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0006163; GO:0006183; GO:0006220; GO:0006228; GO:0006241; GO:0007229; GO:0009142; GO:0030027; GO:0042981; GO:0043066; GO:0043209; GO:0045618; GO:0045682; GO:0045944; GO:0046872; GO:0050679; GO:0070062; GO:0071944; GO:0098779 0 0 0 PF00334; Q04202 CHOYP_contig_043288 m.50001 sp TCB2_CAEBR 29.348 276 187 5 75 347 3 273 2.01E-32 125 TCB2_CAEBR reviewed Transposable element Tcb2 transposase 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; Q04791 CHOYP_LOC100724941.1.1 m.4302 sp SASB_ANAPL 33.752 557 324 13 26 570 26 549 2.01E-94 303 SASB_ANAPL reviewed "Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)" 0 Anas platyrhynchos (Mallard) (Anas boschas) 557 fatty acid biosynthetic process [GO:0006633] GO:0006633; GO:0016787 0 0 0 PF00135; Q14624 CHOYP_BRAFLDRAFT_215239.3.3 m.22952 sp ITIH4_HUMAN 37.621 622 320 12 163 753 34 618 2.01E-121 391 ITIH4_HUMAN reviewed Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) 930 acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; platelet degranulation [GO:0002576]; response to cytokine [GO:0034097] GO:0002576; GO:0004866; GO:0004867; GO:0005576; GO:0005886; GO:0006953; GO:0030212; GO:0031089; GO:0034097; GO:0070062; GO:0072562 0 0 0 PF06668;PF08487;PF00092; Q14978 CHOYP_LOC100117990.1.2 m.60453 sp NOLC1_HUMAN 71.605 81 23 0 764 844 619 699 2.01E-31 135 NOLC1_HUMAN reviewed Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) NOLC1 KIAA0035 NS5ATP13 Homo sapiens (Human) 699 cell cycle [GO:0007049]; mitotic nuclear division [GO:0007067]; nucleolus organization [GO:0007000]; rRNA processing [GO:0006364] GO:0005524; GO:0005525; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0007000; GO:0007049; GO:0007067; GO:0015030; GO:0044822 0 0 0 PF05022; Q19417 CHOYP_LOC100162314.1.1 m.14837 sp YSNK_CAEEL 30.469 128 83 5 200 324 154 278 2.01E-07 57 YSNK_CAEEL reviewed Glycosyltransferase family 92 protein F13G3.3 (EC 2.4.1.-) F13G3.3 Caenorhabditis elegans 501 0 GO:0016021; GO:0016757 0 0 0 PF01697; Q19673 CHOYP_TYRO1.4.6 m.44051 sp TYR3_CAEEL 32.967 364 200 10 113 449 108 454 2.01E-50 192 TYR3_CAEEL reviewed Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans 693 0 GO:0004497; GO:0046872 0 0 0 PF01549;PF00264; Q3SZW1 CHOYP_LOC100370380.1.1 m.49422 sp TSSK1_BOVIN 42.903 310 155 10 58 359 5 300 2.01E-72 232 TSSK1_BOVIN reviewed Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) TSSK1B TSSK1 Bos taurus (Bovine) 367 intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286] GO:0001669; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007275; GO:0007286; GO:0031514; GO:0035556; GO:0046872 0 0 0 PF00069; Q5FVF1 CHOYP_LOC100369464.1.1 m.1338 sp F10C1_RAT 53.333 315 126 7 18 311 1 315 2.01E-102 305 F10C1_RAT reviewed Protein FRA10AC1 homolog Fra10ac1 Rattus norvegicus (Rat) 315 0 GO:0005634 0 0 0 PF09725; Q5T2R2 CHOYP_DPS1.1.1 m.11868 sp DPS1_HUMAN 52.52 377 170 4 32 407 47 415 2.01E-130 384 DPS1_HUMAN reviewed Decaprenyl-diphosphate synthase subunit 1 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 1) (Decaprenyl pyrophosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) PDSS1 DPS1 TPRT Homo sapiens (Human) 415 isoprenoid biosynthetic process [GO:0008299]; protein heterotetramerization [GO:0051290]; ubiquinone biosynthetic process [GO:0006744] GO:0000010; GO:0005759; GO:0006744; GO:0008299; GO:0046872; GO:0046982; GO:0050347; GO:0051290; GO:1990234 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. 0 0 PF00348; Q5VUM1 CHOYP_LOC101278808.1.1 m.63559 sp SDHF4_HUMAN 58.442 77 23 1 32 108 41 108 2.01E-21 84.3 SDHF4_HUMAN reviewed "Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)" SDHAF4 C6orf57 Homo sapiens (Human) 108 innate immune response [GO:0045087] GO:0005759; GO:0045087 0 0 0 PF07896; Q60631 CHOYP_LOC100541322.1.1 m.43256 sp GRB2_MOUSE 58.525 217 81 2 14 228 1 210 2.01E-91 271 GRB2_MOUSE reviewed Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) Grb2 Mus musculus (Mouse) 217 aging [GO:0007568]; anatomical structure formation involved in morphogenesis [GO:0048646]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cell differentiation [GO:0030154]; cellular response to ionizing radiation [GO:0071479]; Fc-epsilon receptor signaling pathway [GO:0038095]; insulin receptor signaling pathway [GO:0008286]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein heterooligomerization [GO:0051291]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of MAPK cascade [GO:0043408]; signal transduction in response to DNA damage [GO:0042770] GO:0005070; GO:0005154; GO:0005168; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005768; GO:0005794; GO:0005829; GO:0005886; GO:0005911; GO:0007265; GO:0007568; GO:0008180; GO:0008286; GO:0012506; GO:0016020; GO:0017124; GO:0019901; GO:0019903; GO:0019904; GO:0030154; GO:0030838; GO:0031623; GO:0038095; GO:0042770; GO:0042802; GO:0043408; GO:0043560; GO:0044822; GO:0046875; GO:0048646; GO:0051291; GO:0060670; GO:0070062; GO:0070436; GO:0071479; GO:2000379 0 0 0 PF00017;PF00018; Q68Y56 CHOYP_TLR8.2.2 m.36110 sp TLR4_PIG 26.374 182 100 4 294 445 421 598 2.01E-07 57 TLR4_PIG reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Sus scrofa (Pig) 841 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0001530; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005887; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13855;PF01582; Q6AY39 CHOYP_BM_BRE5.2.2 m.11515 sp B3GL1_RAT 29.455 275 178 6 102 366 57 325 2.01E-37 140 B3GL1_RAT reviewed "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)" B3galnt1 B3galt3 Rattus norvegicus (Rat) 331 oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008499; GO:0009312; GO:0016021; GO:0047273 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q6DF62 CHOYP_RGN.1.1 m.30406 sp RGN_XENTR 44.371 302 160 4 35 334 4 299 2.01E-88 270 RGN_XENTR reviewed Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) rgn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 299 cellular calcium ion homeostasis [GO:0006874]; L-ascorbic acid biosynthetic process [GO:0019853]; positive regulation of ATPase activity [GO:0032781]; regulation of calcium-mediated signaling [GO:0050848] GO:0004341; GO:0005509; GO:0005634; GO:0005737; GO:0006874; GO:0008270; GO:0019853; GO:0030234; GO:0032781; GO:0050848 PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. 0 0 PF08450; Q6MG82 CHOYP_PRRT1.2.5 m.28553 sp PRRT1_RAT 41.497 147 71 4 71 207 159 300 2.01E-16 79 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q7YU29 CHOYP_DMDE.1.1 m.15110 sp DMDE_DROME 36.29 496 241 13 65 497 409 892 2.01E-85 291 DMDE_DROME reviewed "Dystrophin, isoform E (Protein detached)" Dys det CG34157 Drosophila melanogaster (Fruit fly) 1051 establishment of cell polarity [GO:0030010]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; neuromuscular synaptic transmission [GO:0007274]; regulation of neurotransmitter secretion [GO:0046928]; regulation of short-term neuronal synaptic plasticity [GO:0048172] GO:0003779; GO:0005198; GO:0005737; GO:0005856; GO:0005938; GO:0007274; GO:0007474; GO:0007517; GO:0008092; GO:0008270; GO:0008307; GO:0008586; GO:0016010; GO:0030010; GO:0042383; GO:0045202; GO:0046716; GO:0046928; GO:0048172; GO:0050699 0 0 0 PF09068;PF09069;PF00569; Q8LGG8 CHOYP_SDHC.1.1 m.31277 sp USPAL_ARATH 30.769 91 62 1 2 92 70 159 2.01E-11 60.1 USPAL_ARATH reviewed Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) 175 response to stress [GO:0006950] GO:0005886; GO:0006950; GO:0016208 0 0 0 PF00582; Q90481 CHOYP_BRAFLDRAFT_291065.1.1 m.14515 sp NX22A_DANRE 50.847 236 84 4 8 235 1 212 2.01E-67 215 NX22A_DANRE reviewed Homeobox protein Nkx-2.2a (Homeobox protein NK-2 homolog B-A) nkx2.2a nk2.2 nkx2-2 nkx2.2 Danio rerio (Zebrafish) (Brachydanio rerio) 269 "endocrine pancreas development [GO:0031018]; floor plate development [GO:0033504]; floor plate formation [GO:0021508]; glial cell migration [GO:0008347]; motor neuron axon guidance [GO:0008045]; regulation of transcription, DNA-templated [GO:0006355]; Schwann cell development [GO:0014044]; spinal cord oligodendrocyte cell differentiation [GO:0021529]; spinal cord oligodendrocyte cell fate specification [GO:0021530]; ventral spinal cord interneuron differentiation [GO:0021514]" GO:0005634; GO:0006355; GO:0008045; GO:0008347; GO:0014044; GO:0021508; GO:0021514; GO:0021529; GO:0021530; GO:0031018; GO:0033504; GO:0043565 0 0 0 PF00046; Q92752 CHOYP_BRAFLDRAFT_88602.1.3 m.4254 sp TENR_HUMAN 45.622 217 107 7 71 287 1137 1342 2.01E-50 181 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q95KI0 CHOYP_LOC100725472.1.2 m.5970 sp RFOX1_MACFA 67.48 123 36 2 132 251 85 206 2.01E-48 167 RFOX1_MACFA reviewed RNA binding protein fox-1 homolog 1 (Ataxin-2-binding protein 1) (Fox-1 homolog A) RBFOX1 A2BP1 FOX1 QtrA-11594 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 376 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0008380; GO:0043484 0 0 0 PF12414;PF00076; Q96BZ8 CHOYP_LOC100375896.1.2 m.23761 sp LENG1_HUMAN 39.55 311 133 11 1 303 1 264 2.01E-44 155 LENG1_HUMAN reviewed Leukocyte receptor cluster member 1 LENG1 Homo sapiens (Human) 264 0 0 0 0 0 PF10197; Q99933 CHOYP_BAG1.1.2 m.846 sp BAG1_HUMAN 36.923 195 118 3 1 194 139 329 2.01E-32 122 BAG1_HUMAN reviewed BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) BAG1 HAP Homo sapiens (Human) 345 apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; chaperone cofactor-dependent protein refolding [GO:0070389]; negative regulation of apoptotic process [GO:0043066]; regulation of cellular response to heat [GO:1900034] GO:0000774; GO:0005057; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007166; GO:0043066; GO:0070389; GO:1900034 0 0 0 PF02179;PF00240; Q9BU19 CHOYP_MONBRDRAFT_9339.1.2 m.42762 sp ZN692_HUMAN 45.098 51 28 0 260 310 11 61 2.01E-07 57.4 ZN692_HUMAN reviewed Zinc finger protein 692 ZNF692 Homo sapiens (Human) 519 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q9BW91 CHOYP_LOC756760.1.1 m.1259 sp NUDT9_HUMAN 47.965 344 158 5 7 335 2 339 2.01E-106 318 NUDT9_HUMAN reviewed "ADP-ribose pyrophosphatase, mitochondrial (EC 3.6.1.13) (ADP-ribose diphosphatase) (ADP-ribose phosphohydrolase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (Nucleoside diphosphate-linked moiety X motif 9) (Nudix motif 9)" NUDT9 NUDT10 PSEC0099 UNQ3012/PRO9771 Homo sapiens (Human) 350 ADP catabolic process [GO:0046032]; IDP catabolic process [GO:0046709]; nucleobase-containing small molecule catabolic process [GO:0034656] GO:0005622; GO:0005759; GO:0019144; GO:0034656; GO:0043262; GO:0046032; GO:0046709; GO:0047631; GO:0070062 0 0 0 PF00293; Q9ER47 CHOYP_LOC100371738.1.3 m.30033 sp KCNH7_MOUSE 57.534 146 51 3 90 234 389 524 2.01E-48 173 KCNH7_MOUSE reviewed Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (Voltage-gated potassium channel subunit Kv11.3) Kcnh7 Erg3 Mus musculus (Mouse) 1195 regulation of membrane potential [GO:0042391] GO:0005249; GO:0005887; GO:0042391 0 0 0 PF00027;PF00520;PF13426; Q9H0J4 CHOYP_BRAFLDRAFT_119031.1.2 m.19501 sp QRIC2_HUMAN 39.13 276 147 4 63 324 1251 1519 2.01E-59 209 QRIC2_HUMAN reviewed Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 0 0 0 0 0 PF16043; Q9JHX4 CHOYP_LOC780455.1.1 m.65356 sp CASP8_RAT 29.31 116 71 3 2 109 293 405 2.01E-08 53.5 CASP8_RAT reviewed Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Rattus norvegicus (Rat) 482 activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage differentiation [GO:0045651]; protein heterooligomerization [GO:0051291]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to cold [GO:0009409]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; TRAIL-activated apoptotic signaling pathway [GO:0036462] GO:0004197; GO:0005123; GO:0005164; GO:0005654; GO:0005739; GO:0005815; GO:0005829; GO:0006508; GO:0006915; GO:0008625; GO:0009409; GO:0030225; GO:0031264; GO:0031265; GO:0032025; GO:0032355; GO:0032403; GO:0032496; GO:0034612; GO:0035877; GO:0036462; GO:0042981; GO:0043005; GO:0043123; GO:0043124; GO:0043234; GO:0044297; GO:0045121; GO:0045471; GO:0045651; GO:0046677; GO:0051291; GO:0051603; GO:0071260; GO:0071407; GO:0097153; GO:0097194; GO:0097199; GO:0097202; GO:0097342 0 0 0 PF01335; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.7.15 m.37873 sp SACS_MOUSE 28.772 928 560 37 1 867 780 1667 2.01E-87 309 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLC8 CHOYP_SACS.15.17 m.63399 sp SACS_MOUSE 23.504 685 432 22 1 623 3409 4063 2.01E-30 132 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9NQG7 CHOYP_BRAFLDRAFT_84245.1.2 m.42980 sp HPS4_HUMAN 31.22 205 134 2 23 227 18 215 2.01E-18 87 HPS4_HUMAN reviewed Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog) HPS4 KIAA1667 Homo sapiens (Human) 708 blood coagulation [GO:0007596]; hemostasis [GO:0007599]; lysosome organization [GO:0007040]; melanocyte differentiation [GO:0030318]; positive regulation of eye pigmentation [GO:0048075]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein stabilization [GO:0050821]; protein targeting [GO:0006605] GO:0005737; GO:0005764; GO:0006605; GO:0007040; GO:0007596; GO:0007599; GO:0016020; GO:0030318; GO:0031085; GO:0042470; GO:0042803; GO:0042827; GO:0046983; GO:0048075; GO:0050821; GO:1903955 0 0 0 0 Q9UBW7 CHOYP_BRAFLDRAFT_106251.1.6 m.8962 sp ZMYM2_HUMAN 23.592 284 166 11 83 333 1094 1359 2.01E-09 63.9 ZMYM2_HUMAN reviewed Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) ZMYM2 FIM RAMP ZNF198 Homo sapiens (Human) 1377 "cytoskeleton organization [GO:0007010]; multicellular organism development [GO:0007275]; regulation of cell morphogenesis [GO:0022604]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0004713; GO:0005737; GO:0005829; GO:0006351; GO:0007010; GO:0007275; GO:0008270; GO:0016605; GO:0022604; GO:0031624 0 0 0 PF12012;PF06467; Q9W596 CHOYP_SRC.1.2 m.2503 sp FUTSC_DROME 40.164 488 248 10 31 497 116 580 2.01E-116 407 FUTSC_DROME reviewed Microtubule-associated protein futsch (MAP1B homolog) [Cleaved into: Futsch heavy chain; Futsch light chain LC(f)] futsch CG34387 Drosophila melanogaster (Fruit fly) 5495 axo-dendritic transport [GO:0008088]; axonogenesis [GO:0007409]; compound eye development [GO:0048749]; dendrite morphogenesis [GO:0048813]; microtubule-based process [GO:0007017]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron death [GO:1901215]; nervous system development [GO:0007399]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular junction development [GO:0007528]; olfactory learning [GO:0008355]; regulation of synaptic growth at neuromuscular junction [GO:0008582] GO:0000226; GO:0005737; GO:0005874; GO:0005875; GO:0007017; GO:0007399; GO:0007409; GO:0007528; GO:0008017; GO:0008088; GO:0008355; GO:0008582; GO:0015630; GO:0019900; GO:0030424; GO:0030425; GO:0043025; GO:0043524; GO:0048749; GO:0048813; GO:0060052; GO:1901215 0 0 0 PF06740; Q9WTY8 CHOYP_PODANSG09984.1.1 m.31196 sp ZBT10_RAT 48.148 54 27 1 78 131 689 741 2.01E-10 60.5 ZBT10_RAT reviewed Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) Zbtb10 Rinzf Rattus norvegicus (Rat) 836 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00651; B1AR13 CHOYP_MED21.1.1 m.6954 sp CISD3_MOUSE 33.813 139 82 3 7 145 1 129 2.02E-21 87 CISD3_MOUSE reviewed "CDGSH iron-sulfur domain-containing protein 3, mitochondrial (Melanoma nuclear protein 13)" Cisd3 Mel-13 Mel13 Mus musculus (Mouse) 137 0 GO:0005739; GO:0046872; GO:0051537 0 0 0 PF09360; E7F6F9 CHOYP_LOC100690119.1.1 m.19412 sp KLHL3_DANRE 28.283 99 64 2 27 121 60 155 2.02E-06 53.5 KLHL3_DANRE reviewed Kelch-like protein 3 klhl3 Danio rerio (Zebrafish) (Brachydanio rerio) 601 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O42175 CHOYP_LOC101169721.1.1 m.7445 sp APOA1_SPAAU 52.471 263 122 1 17 279 1 260 2.02E-88 266 APOA1_SPAAU reviewed Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I)] apoa1 Sparus aurata (Gilthead sea bream) 260 cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; lipoprotein metabolic process [GO:0042157] GO:0006869; GO:0008203; GO:0008289; GO:0034364; GO:0042157 0 0 0 PF01442; O95677 CHOYP_BRAFLDRAFT_83679.1.2 m.38918 sp EYA4_HUMAN 48.6 607 246 18 94 649 48 639 2.02E-166 493 EYA4_HUMAN reviewed Eyes absent homolog 4 (EC 3.1.3.48) EYA4 Homo sapiens (Human) 639 "anatomical structure morphogenesis [GO:0009653]; covalent chromatin modification [GO:0016569]; DNA repair [GO:0006281]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; sensory perception of sound [GO:0007605]; transcription, DNA-templated [GO:0006351]; visual perception [GO:0007601]" GO:0004725; GO:0005634; GO:0005737; GO:0006281; GO:0006351; GO:0006355; GO:0007275; GO:0007601; GO:0007605; GO:0009653; GO:0016569; GO:0046872 0 0 0 0 P10079 CHOYP_LOC100632098.4.13 m.13772 sp FBP1_STRPU 46.138 479 247 3 10 477 79 557 2.02E-132 411 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11031 CHOYP_LOC100900939.1.1 m.15284 sp TCP4_MOUSE 48.031 127 62 2 1 123 1 127 2.02E-24 93.2 TCP4_MOUSE reviewed Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (Single-stranded DNA-binding protein p9) (p14) Sub1 Pc4 Rpo2tc1 Mus musculus (Mouse) 127 regulation of transcription from RNA polymerase II promoter [GO:0006357]; SMAD protein signal transduction [GO:0060395] GO:0001205; GO:0003697; GO:0003713; GO:0005634; GO:0005667; GO:0005730; GO:0006357; GO:0044822; GO:0060395; GO:0070062 0 0 0 PF02229; P24635 CHOYP_TPC2.2.2 m.36987 sp TBA_OCTVU 62.791 86 30 2 1 85 35 119 2.02E-27 103 TBA_OCTVU reviewed Tubulin alpha chain (Fragment) 0 Octopus vulgaris (Common octopus) 240 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P31597 CHOYP_LOC100691601.2.2 m.40748 sp EAA3_RABIT 51.272 511 221 8 12 515 1 490 2.02E-166 484 EAA3_RABIT reviewed Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 Oryctolagus cuniculus (Rabbit) 524 cysteine transport [GO:0042883]; D-aspartate import [GO:0070779]; L-glutamate transmembrane transport [GO:0089711] GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0016324; GO:0033229; GO:0042883; GO:0070779; GO:0089711 0 0 0 PF00375; P49013 CHOYP_LOC575027.6.6 m.54448 sp FBP3_STRPU 45.89 146 69 4 111 248 185 328 2.02E-29 126 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P49116 CHOYP_LOC100372115.1.1 m.11016 sp NR2C2_HUMAN 30.419 549 269 20 8 501 91 581 2.02E-61 214 NR2C2_HUMAN reviewed Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4) NR2C2 TAK1 TR4 Homo sapiens (Human) 596 "cell differentiation [GO:0030154]; cerebellum development [GO:0021549]; meiotic cell cycle [GO:0051321]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nervous system development [GO:0007399]; p38MAPK cascade [GO:0038066]; positive regulation of behavior [GO:0048520]; positive regulation of embryonic development [GO:0040019]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0003700; GO:0003707; GO:0003713; GO:0004872; GO:0005654; GO:0006355; GO:0006367; GO:0007283; GO:0007399; GO:0008270; GO:0021549; GO:0030154; GO:0038066; GO:0040019; GO:0043565; GO:0045663; GO:0045944; GO:0046982; GO:0048520; GO:0051321; GO:0098779 0 0 0 PF00104;PF00105; P56590 CHOYP_LOC100920270.1.1 m.18863 sp CP1A1_CANLF 34.818 494 300 8 54 530 13 501 2.02E-86 280 CP1A1_CANLF reviewed Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (DAH1) CYP1A1 Canis lupus familiaris (Dog) (Canis familiaris) 524 0 GO:0004497; GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0043231; GO:0070330 0 0 0 PF00067; P70195 CHOYP_LOC100370401.1.1 m.15416 sp PSB7_MOUSE 72.059 272 72 1 19 286 1 272 2.02E-142 404 PSB7_MOUSE reviewed Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z) Psmb7 Mmc14 Mus musculus (Mouse) 277 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis involved in cellular protein catabolic process [GO:0051603]" GO:0000502; GO:0002479; GO:0004298; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005839; GO:0051603; GO:0070062; GO:1903955 0 0 0 PF12465;PF00227; P97478 CHOYP_LOC100638372.1.1 m.60469 sp COQ7_MOUSE 66.092 174 59 0 20 193 42 215 2.02E-83 249 COQ7_MOUSE reviewed "5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.13.-) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)" Coq7 Mus musculus (Mouse) 217 age-dependent response to oxidative stress [GO:0001306]; cellular response to oxidative stress [GO:0034599]; determination of adult lifespan [GO:0008340]; in utero embryonic development [GO:0001701]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrion morphogenesis [GO:0070584]; neural tube formation [GO:0001841]; neurogenesis [GO:0022008]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979]; ubiquinone biosynthetic process [GO:0006744] GO:0001306; GO:0001701; GO:0001841; GO:0005634; GO:0005739; GO:0006744; GO:0006979; GO:0008340; GO:0016709; GO:0022008; GO:0022904; GO:0031314; GO:0034599; GO:0042775; GO:0046872; GO:0070584 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03194}. 0 cd01042; PF03232; Q05A62 CHOYP_DNAL1.1.1 m.11822 sp DNAL1_MOUSE 75.132 189 47 0 21 209 2 190 2.02E-98 286 DNAL1_MOUSE reviewed "Dynein light chain 1, axonemal" Dnal1 Dnalc1 Mus musculus (Mouse) 190 0 GO:0036157 0 0 0 0 Q08E40 CHOYP_S39AC.1.1 m.43170 sp S39AC_BOVIN 35.097 359 165 7 3 359 362 654 2.02E-56 197 S39AC_BOVIN reviewed Zinc transporter ZIP12 (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12) SLC39A12 ZIP12 Bos taurus (Bovine) 654 cellular zinc ion homeostasis [GO:0006882]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; signal transduction [GO:0007165]; zinc II ion transmembrane import [GO:0071578] GO:0005385; GO:0005887; GO:0006882; GO:0007165; GO:0010975; GO:0031113; GO:0048471; GO:0071578; GO:1903561 0 0 0 PF02535; Q0VFH6 CHOYP_RM22.1.1 m.63127 sp RM22_XENTR 39.109 202 91 6 20 216 22 196 2.02E-37 132 RM22_XENTR reviewed "39S ribosomal protein L22, mitochondrial (L22mt) (MRP-L22)" mrpl22 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 204 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005762; GO:0006412 0 0 cd00336; PF00237; Q49LS8 CHOYP_SPTC2.2.4 m.21507 sp XKR6_TETNG 26.136 264 151 5 167 404 83 328 2.02E-17 89.4 XKR6_TETNG reviewed XK-related protein 6 xkr6 xrg6 GSTENG00030285001 GSTENG00030286001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 578 0 GO:0016021 0 0 0 PF09815; Q4L818 CHOYP_NEMVEDRAFT_V1G241446.1.2 m.22601 sp PDP_STAHJ 38.889 90 52 2 7 94 339 427 2.02E-09 56.2 PDP_STAHJ reviewed Pyrimidine-nucleoside phosphorylase (PYNP) (Py-NPase) (EC 2.4.2.2) pdp pyn SH0898 Staphylococcus haemolyticus (strain JCSC1435) 433 pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213] GO:0004645; GO:0006206; GO:0006213; GO:0016154; GO:0046872 0 0 0 PF02885;PF00591;PF07831; Q4PM12 CHOYP_MCM4.1.1 m.61256 sp RL36_IXOSC 60.784 102 38 1 1 102 1 100 2.02E-39 130 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q4V8V1 CHOYP_BRM1L.1.1 m.57812 sp BM1LA_DANRE 56.79 243 88 5 4 241 1 231 2.02E-83 255 BM1LA_DANRE reviewed Breast cancer metastasis-suppressor 1-like protein-A brms1la brms1l zgc:114129 Danio rerio (Zebrafish) (Brachydanio rerio) 323 "histone deacetylation [GO:0016575]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0006351; GO:0016575; GO:0042826; GO:0070822 0 0 0 PF08598; Q55E58 CHOYP_TRIADDRAFT_60922.2.2 m.61325 sp PATS1_DICDI 23.826 298 175 9 296 583 1768 2023 2.02E-14 82 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5REG4 CHOYP_DTX3L.4.4 m.58499 sp DTX3_PONAB 52.105 190 90 1 763 951 157 346 2.02E-57 204 DTX3_PONAB reviewed Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 347 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] GO:0005737; GO:0007219; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q5ZIJ9 CHOYP_LOC100370069.8.14 m.53805 sp MIB2_CHICK 35.065 77 43 1 585 654 9 85 2.02E-06 55.5 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6DH46 CHOYP_ACPL2.1.1 m.49176 sp PXYP1_DANRE 32.673 202 128 5 67 263 46 244 2.02E-24 104 PXYP1_DANRE reviewed 2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) pxylp1 acpl2 zgc:92652 Danio rerio (Zebrafish) (Brachydanio rerio) 503 chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909] GO:0000139; GO:0003993; GO:0005794; GO:0006024; GO:0010909; GO:0016021; GO:0016791; GO:0050650 0 0 cd07061; PF00328; Q6GMG8 CHOYP_NEMVEDRAFT_V1G99547.4.4 m.66400 sp LITAF_DANRE 37.391 115 67 3 153 263 49 162 2.02E-14 72.4 LITAF_DANRE reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf zgc:91882 Danio rerio (Zebrafish) (Brachydanio rerio) 163 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006355 0 0 0 PF10601; Q6R7G0 CHOYP_Y054.1.1 m.9666 sp Y068_OSHVF 20.123 487 339 15 144 592 157 631 2.02E-14 80.5 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6ZRF8 CHOYP_LOC100374741.77.83 m.60885 sp RN207_HUMAN 20.313 320 203 10 33 346 103 376 2.02E-07 57.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_LOC100374981.15.16 m.65559 sp RN207_HUMAN 30 80 52 3 17 96 103 178 2.02E-06 47.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7Z0T3 CHOYP_ACDOPBH.8.9 m.52946 sp TEMPT_APLCA 50.442 113 55 1 4 115 8 120 2.02E-30 118 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q7ZU45 CHOYP_LOC100372889.1.2 m.37507 sp TTC25_DANRE 48.162 272 137 2 12 279 215 486 2.02E-84 266 TTC25_DANRE reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) 486 cilium assembly [GO:0042384]; determination of heart left/right asymmetry [GO:0061371]; otolith morphogenesis [GO:0032474] GO:0032474; GO:0042384; GO:0061371 0 0 0 0 Q8C8H8 CHOYP_LOC100552773.2.2 m.28170 sp KY_MOUSE 28.041 485 312 15 38 512 152 609 2.02E-44 170 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8IZF0 CHOYP_NALCN.1.1 m.41062 sp NALCN_HUMAN 82.474 97 17 0 1 97 1098 1194 2.02E-50 174 NALCN_HUMAN reviewed Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1) NALCN VGCNL1 Homo sapiens (Human) 1738 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; ion transmembrane transport [GO:0034220]; membrane depolarization during action potential [GO:0086010]; potassium ion transmembrane transport [GO:0071805]; regulation of resting membrane potential [GO:0060075]; sodium ion transmembrane transport [GO:0035725] GO:0005244; GO:0005261; GO:0005272; GO:0005886; GO:0006816; GO:0016021; GO:0022840; GO:0034220; GO:0035725; GO:0060075; GO:0070588; GO:0071805; GO:0086010 0 0 0 PF00520; Q91FU0 CHOYP_DICPUDRAFT_75027.3.3 m.56477 sp VF232_IIV6 31.788 151 91 4 174 322 380 520 2.02E-10 68.6 VF232_IIV6 reviewed Putative ubiquitin thioesterase 232R (EC 3.4.19.12) IIV6-232R Invertebrate iridescent virus 6 (IIV-6) (Chilo iridescent virus) 671 "DNA-templated transcription, termination [GO:0006353]" GO:0006353; GO:0036459 0 0 0 PF08793;PF02338; Q92010 CHOYP_LOC100564140.2.2 m.10031 sp ZBT14_CHICK 42.017 119 66 1 18 136 326 441 2.02E-22 102 ZBT14_CHICK reviewed Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 5) (ZF5) ZBTB14 ZFP161 Gallus gallus (Chicken) 448 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0044212; GO:0045892; GO:0046872 0 0 0 PF00651;PF00096; Q92193 CHOYP_LOC100533345.1.2 m.44846 sp ACT_CRAVI 97.931 145 3 0 3 147 1 145 2.02E-101 295 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96RW7 CHOYP_BRAFLDRAFT_88566.3.11 m.5108 sp HMCN1_HUMAN 44.271 384 204 2 25 398 4485 4868 2.02E-95 323 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BUT9 CHOYP_LOC101067628.1.1 m.57607 sp F195A_HUMAN 39.423 104 55 5 61 161 59 157 2.02E-13 67 F195A_HUMAN reviewed Protein FAM195A FAM195A C16orf14 Homo sapiens (Human) 160 0 0 0 0 0 PF14799; Q9ESN6 CHOYP_BRAFLDRAFT_102380.9.11 m.64633 sp TRIM2_MOUSE 31.148 183 110 9 72 249 536 707 2.02E-14 75.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HC56 CHOYP_PCDH1.2.3 m.8055 sp PCDH9_HUMAN 33.603 741 478 10 5 738 6 739 2.02E-105 360 PCDH9_HUMAN reviewed Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0030426; GO:0030900; GO:0044291 0 0 0 PF00028;PF08266;PF08374; Q9LZG0 CHOYP_LOC101173404.1.1 m.27554 sp ADK2_ARATH 44.625 307 168 1 62 368 8 312 2.02E-95 291 ADK2_ARATH reviewed Adenosine kinase 2 (AK 2) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase 2) ADK2 At5g03300 F12E4.30 MOK16.21 Arabidopsis thaliana (Mouse-ear cress) 345 adenosine salvage [GO:0006169]; AMP salvage [GO:0044209]; viral process [GO:0016032] GO:0004001; GO:0005507; GO:0005524; GO:0005829; GO:0005886; GO:0006169; GO:0016032; GO:0044209 PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. 0 0 PF00294; Q9UIW2 CHOYP_LOC100121278.1.1 m.1990 sp PLXA1_HUMAN 39.326 178 98 5 11 180 241 416 2.02E-34 132 PLXA1_HUMAN reviewed Plexin-A1 (Semaphorin receptor NOV) PLXNA1 NOV PLXN1 Homo sapiens (Human) 1896 branchiomotor neuron axon guidance [GO:0021785]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; multicellular organism development [GO:0007275]; neuron projection extension [GO:1990138]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of smooth muscle cell migration [GO:0014910]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0002116; GO:0004872; GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0007275; GO:0014910; GO:0017154; GO:0021785; GO:0030334; GO:0048841; GO:0060666; GO:0070062; GO:1902287; GO:1990138 0 0 0 PF08337;PF01437;PF01403;PF01833; Q9VCA8 CHOYP_TVAG_485460.1.1 m.23563 sp ANKHM_DROME 33.234 337 196 11 543 861 550 875 2.02E-34 146 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VUL9 CHOYP_PHUM_PHUM491860.1.1 m.2608 sp FUCTA_DROME 46.133 362 176 10 62 413 136 488 2.02E-100 310 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q9WWW2 CHOYP_LOC100877446.1.2 m.4975 sp ALKJ_PSEPU 40.522 575 282 16 38 596 2 532 2.02E-115 358 ALKJ_PSEPU reviewed Alcohol dehydrogenase [acceptor] (EC 1.1.99.-) alkJ Pseudomonas putida (Arthrobacter siderocapsulatus) 552 0 GO:0005886; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; Q9Z1L4 CHOYP_LOC589087.1.1 m.29428 sp XLRS1_MOUSE 41.228 114 63 2 74 187 111 220 2.02E-20 91.7 XLRS1_MOUSE reviewed Retinoschisin (X-linked juvenile retinoschisis protein homolog) Rs1 Rs1h Xlrs1 Mus musculus (Mouse) 224 adaptation of rhodopsin mediated signaling [GO:0016062]; cell adhesion [GO:0007155]; retina layer formation [GO:0010842] GO:0001786; GO:0005546; GO:0005547; GO:0005576; GO:0007155; GO:0010314; GO:0010842; GO:0016062; GO:0019897; GO:0032266; GO:0043325; GO:0070273; GO:0080025 0 0 0 PF00754; A7MBP4 CHOYP_LOC590756.5.6 m.56367 sp IFT46_DANRE 70.614 228 60 2 30 257 143 363 2.03E-112 332 IFT46_DANRE reviewed Intraflagellar transport protein 46 homolog ift46 Danio rerio (Zebrafish) (Brachydanio rerio) 384 cilium assembly [GO:0042384]; determination of ventral identity [GO:0048264]; intraciliary transport [GO:0042073]; pronephros development [GO:0048793]; retina development in camera-type eye [GO:0060041] GO:0005737; GO:0005813; GO:0030992; GO:0036064; GO:0042073; GO:0042384; GO:0048264; GO:0048793; GO:0060041 0 0 0 PF12317; A7YY35 CHOYP_LOC100893512.1.1 m.57777 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 2.03E-19 98.2 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; D2GXS7 CHOYP_BRAFLDRAFT_87269.7.8 m.53332 sp TRIM2_AILME 24.706 255 178 6 142 384 492 744 2.03E-12 72.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_TRIM2.22.59 m.32972 sp TRIM2_AILME 31.967 122 79 3 20 138 622 742 2.03E-11 63.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZQG6 CHOYP_BRAFLDRAFT_63298.2.6 m.32416 sp TRIM2_RAT 27.488 211 122 9 69 263 536 731 2.03E-08 58.2 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O16025 CHOYP_LOC584481.9.10 m.62241 sp AOSL_PLEHO 28.834 489 292 14 152 604 598 1066 2.03E-49 188 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O35115 CHOYP_LOC100160412.2.2 m.56352 sp FHL2_RAT 52.817 284 126 1 332 615 3 278 2.03E-109 333 FHL2_RAT reviewed Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) Fhl2 Dral Slim3 Rattus norvegicus (Rat) 279 "atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; transcription, DNA-templated [GO:0006351]; ventricular cardiac muscle cell development [GO:0055015]" GO:0000122; GO:0001649; GO:0005634; GO:0005925; GO:0006351; GO:0008134; GO:0008270; GO:0009725; GO:0015629; GO:0030018; GO:0031430; GO:0043066; GO:0055014; GO:0055015; GO:0060347 0 0 0 PF00412; O46160 CHOYP_LOC100668162.1.1 m.57140 sp RL14_LUMRU 61.386 101 39 0 3 103 1 101 2.03E-39 131 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O55060 CHOYP_LOC101064328.1.3 m.13179 sp TPMT_MOUSE 33.182 220 141 5 41 254 19 238 2.03E-31 119 TPMT_MOUSE reviewed Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) Tpmt Mus musculus (Mouse) 240 nucleobase-containing compound metabolic process [GO:0006139] GO:0005737; GO:0006139; GO:0008119; GO:0070062 0 0 0 PF05724; O75179 CHOYP_LOC581927.2.27 m.14271 sp ANR17_HUMAN 38.971 136 77 4 6 137 510 643 2.03E-18 83.6 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O95235 CHOYP_LOC100368346.1.2 m.11502 sp KI20A_HUMAN 38.126 779 400 21 40 790 65 789 2.03E-135 451 KI20A_HUMAN reviewed Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) KIF20A MKLP2 RAB6KIFL Homo sapiens (Human) 890 cell separation after cytokinesis [GO:0000920]; cytokinesis [GO:0000910]; microtubule-based movement [GO:0007018]; microtubule bundle formation [GO:0001578]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0000281; GO:0000910; GO:0000920; GO:0001578; GO:0003777; GO:0005215; GO:0005524; GO:0005654; GO:0005794; GO:0005819; GO:0005871; GO:0005874; GO:0007018; GO:0015031; GO:0016192; GO:0016887; GO:0019901; GO:0030496 0 0 0 PF00225; P07814 CHOYP_LOC100376708.1.2 m.4374 sp SYEP_HUMAN 28.155 103 73 1 6 107 4 106 2.03E-08 53.9 SYEP_HUMAN reviewed Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)] EPRS GLNS PARS QARS QPRS PIG32 Homo sapiens (Human) 1512 cellular response to interferon-gamma [GO:0071346]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; protein complex assembly [GO:0006461]; tRNA aminoacylation for protein translation [GO:0006418] GO:0004818; GO:0004827; GO:0005524; GO:0005737; GO:0005829; GO:0006418; GO:0006424; GO:0006433; GO:0006461; GO:0016020; GO:0017101; GO:0017148; GO:0030529; GO:0035613; GO:0051020; GO:0071346; GO:0097452 0 0 cd00778; PF00043;PF03129;PF09180;PF00749;PF03950;PF00587;PF00458; P0CH27 CHOYP_LOC101209425.1.2 m.828 sp RL402_TRYCR 86.082 194 27 0 1 194 163 356 2.03E-120 347 RL402_TRYCR reviewed Ubiquitin-60S ribosomal protein L40 [Cleaved into: Ubiquitin; 60S ribosomal protein L40] 0 Trypanosoma cruzi 356 translation [GO:0006412] GO:0003735; GO:0005634; GO:0005840; GO:0006412 0 0 0 PF01020;PF00240; P0DMN0 CHOYP_LOC100764411.1.1 m.56966 sp ST1A4_HUMAN 31.786 280 164 6 16 274 19 292 2.03E-45 157 ST1A4_HUMAN reviewed Sulfotransferase 1A4 (ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Sulfotransferase 1A3/1A4) SULT1A4 Homo sapiens (Human) 295 catecholamine metabolic process [GO:0006584]; steroid metabolic process [GO:0008202] GO:0004062; GO:0005737; GO:0006584; GO:0008202 0 0 0 PF00685; P10079 CHOYP_FBP1.1.7 m.4170 sp FBP1_STRPU 36.27 488 277 8 1 454 322 809 2.03E-86 291 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_LOC575027.5.6 m.54447 sp FBP1_STRPU 54.519 343 154 2 105 447 216 556 2.03E-112 371 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P26258 CHOYP_ASGR1.1.2 m.2866 sp TETN_CARPZ 30.233 129 83 4 37 162 37 161 2.03E-12 64.7 TETN_CARPZ reviewed Tetranectin-like protein 0 Carcharhinus perezii (Reef shark) (Carcharhinus springeri) 166 0 GO:0030246 0 0 0 PF00059; P29314 CHOYP_RS9.1.13 m.19719 sp RS9_RAT 90.341 176 13 1 21 192 1 176 2.03E-109 314 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P48236 CHOYP_LOC100889030.1.1 m.39939 sp YG3L_YEAST 40.476 126 72 3 26 149 105 229 2.03E-19 87.8 YG3L_YEAST reviewed Uncharacterized membrane protein YGR149W YGR149W G6639 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 432 0 GO:0016021 0 0 0 PF10998; P51589 CHOYP_LOC100950432.1.1 m.25908 sp CP2J2_HUMAN 34.711 484 299 9 15 490 22 496 2.03E-88 283 CP2J2_HUMAN reviewed Cytochrome P450 2J2 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ2) CYP2J2 Homo sapiens (Human) 502 epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; linoleic acid metabolic process [GO:0043651]; regulation of heart contraction [GO:0008016]; xenobiotic metabolic process [GO:0006805] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0006805; GO:0008016; GO:0008392; GO:0008395; GO:0008404; GO:0008405; GO:0019373; GO:0020037; GO:0031090; GO:0043651; GO:0070062; GO:0070330; GO:0071614 0 0 0 PF00067; P54316 CHOYP_LIPR1.2.3 m.4679 sp LIPR1_RAT 44.025 318 167 5 38 348 16 329 2.03E-80 256 LIPR1_RAT reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) Pnliprp1 Plrp1 Rattus norvegicus (Rat) 473 lipid metabolic process [GO:0006629]; pancreas development [GO:0031016]; response to glucocorticoid [GO:0051384]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005509; GO:0005615; GO:0006629; GO:0016298; GO:0031016; GO:0043434; GO:0051384 0 0 0 PF00151;PF01477; Q08D57 CHOYP_LOC657811.1.1 m.29214 sp SET1B_XENTR 58.842 311 112 5 1262 1564 1654 1956 2.03E-104 373 SET1B_XENTR reviewed Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.43) (SET domain-containing protein 1B) setd1b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1956 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003723; GO:0005694; GO:0006351; GO:0006355; GO:0016607; GO:0018024 0 0 0 PF11764;PF00076;PF00856; Q09624 CHOYP_REJ6.3.4 m.37073 sp PKD1_CAEEL 23.814 1075 682 36 1857 2879 2242 3231 2.03E-63 246 PKD1_CAEEL reviewed Location of vulva defective 1 (Polycystic kidney disease 1 protein homolog) (Polycystin-1) lov-1 pkd-1 ZK945.9/ZK945.10 Caenorhabditis elegans 3284 detection of mechanical stimulus [GO:0050982]; male mating behavior [GO:0060179]; mating behavior [GO:0007617]; response to hermaphrodite contact [GO:0034606]; vulval location [GO:0034608] GO:0005262; GO:0005929; GO:0007617; GO:0016020; GO:0016021; GO:0019904; GO:0031513; GO:0034606; GO:0034608; GO:0043025; GO:0050982; GO:0060179 0 0 0 PF08016;PF01477; Q0DXS3 CHOYP_BRAFLDRAFT_99723.2.9 m.4282 sp RDR1_ORYSJ 40.219 731 367 22 383 1074 20 719 2.03E-140 452 RDR1_ORYSJ reviewed Probable RNA-dependent RNA polymerase 1 (OsRDR1) (EC 2.7.7.48) RDR1 Os02g0736200 LOC_Os02g50330 Oryza sativa subsp. japonica (Rice) 740 gene silencing by RNA [GO:0031047] GO:0003723; GO:0003968; GO:0031047 0 0 0 PF05183; Q0MQI9 CHOYP_CRE_00778.1.1 m.49409 sp NDUV2_PANTR 68.153 157 45 2 1 157 98 249 2.03E-72 220 NDUV2_PANTR reviewed "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase 24 kDa subunit)" NDUFV2 Pan troglodytes (Chimpanzee) 249 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]" GO:0005747; GO:0006120; GO:0008137; GO:0046872; GO:0051537 0 0 0 0 Q12955 CHOYP_TVAG_168010.4.45 m.12611 sp ANK3_HUMAN 32.891 377 253 0 3 379 399 775 2.03E-66 231 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q14103 CHOYP_ROAA.5.6 m.58211 sp HNRPD_HUMAN 47.706 109 57 0 3 111 150 258 2.03E-28 108 HNRPD_HUMAN reviewed Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) HNRNPD AUF1 HNRPD Homo sapiens (Human) 355 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to amino acid stimulus [GO:0071230]; cellular response to estradiol stimulus [GO:0071392]; cellular response to nitric oxide [GO:0071732]; cellular response to putrescine [GO:1904586]; cerebellum development [GO:0021549]; circadian regulation of translation [GO:0097167]; gene expression [GO:0010467]; hepatocyte dedifferentiation [GO:1990828]; liver development [GO:0001889]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of translation [GO:0045727]; regulation of circadian rhythm [GO:0042752]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to fluoxetine [GO:0014076]; response to rapamycin [GO:1901355]; response to sodium phosphate [GO:1904383]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0000398; GO:0001889; GO:0003680; GO:0003682; GO:0003723; GO:0005634; GO:0005654; GO:0005829; GO:0006351; GO:0006355; GO:0006396; GO:0006401; GO:0010467; GO:0014076; GO:0021549; GO:0030529; GO:0035925; GO:0042162; GO:0042752; GO:0043488; GO:0044822; GO:0045727; GO:0045893; GO:0048255; GO:0051592; GO:0051602; GO:0061158; GO:0070062; GO:0071230; GO:0071392; GO:0071732; GO:0097167; GO:1901355; GO:1904383; GO:1904586; GO:1990828 0 0 0 PF08143;PF00076; Q16994 CHOYP_PAR12.1.1 m.24821 sp FMR2_ANTEL 33.333 129 86 0 10 138 202 330 2.03E-11 64.3 FMR2_ANTEL reviewed Antho-RFamide neuropeptides type 2 [Cleaved into: Antho-RFamide] 0 Anthopleura elegantissima (Sea anemone) 429 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF01581; Q23157 CHOYP_TSP_10030.1.3 m.38957 sp INX11_CAEEL 27.296 392 241 9 7 365 20 400 2.03E-38 147 INX11_CAEEL reviewed Innexin-11 (Protein opu-11) inx-11 opu-11 W04D2.3 Caenorhabditis elegans 465 ion transport [GO:0006811] GO:0005243; GO:0005886; GO:0005921; GO:0006811; GO:0016021; GO:0055077; GO:1903763 0 0 0 PF00876; Q27237 CHOYP_CSPA_C15740.1.1 m.59258 sp TID_DROME 49.333 75 36 2 27 99 54 128 2.03E-13 70.1 TID_DROME reviewed "Protein tumorous imaginal discs, mitochondrial (Protein lethal(2)tumorous imaginal discs) (TID50) (TID56)" l(2)tid CG5504 Drosophila melanogaster (Fruit fly) 520 mitochondrion organization [GO:0007005]; multicellular organism development [GO:0007275]; protein folding [GO:0006457]; regulation of apoptotic process [GO:0042981]; response to heat [GO:0009408]; sleep [GO:0030431]; smoothened signaling pathway [GO:0007224] GO:0005113; GO:0005524; GO:0005739; GO:0005741; GO:0005829; GO:0006457; GO:0007005; GO:0007224; GO:0007275; GO:0009408; GO:0030431; GO:0042981; GO:0046872 0 0 cd06257; PF00226;PF01556;PF00684; Q2Q0I9 CHOYP_YPF11.1.2 m.39487 sp FNDC1_RAT 38.686 137 66 6 573 703 1652 1776 2.03E-21 103 FNDC1_RAT reviewed Fibronectin type III domain-containing protein 1 (Activator of G-protein signaling 8) Fndc1 Ags8 Rattus norvegicus (Rat) 1779 cellular response to hypoxia [GO:0071456]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein transport [GO:0051223] GO:0001934; GO:0005576; GO:0005737; GO:0005886; GO:0005911; GO:0010666; GO:0031966; GO:0051223; GO:0071456 0 0 0 PF00041; Q5R7J8 CHOYP_TP4A2.1.1 m.2194 sp TP4A1_PONAB 60.811 74 29 0 5 78 3 76 2.03E-26 99 TP4A1_PONAB reviewed Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) PTP4A1 PRL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 173 cell cycle [GO:0007049]; multicellular organism development [GO:0007275] GO:0004725; GO:0005769; GO:0005783; GO:0005819; GO:0005886; GO:0007049; GO:0007275; GO:0008138 0 0 0 PF00782; Q5RGB8 CHOYP_KLH26.2.2 m.10030 sp KLH26_DANRE 39.865 148 86 2 7 151 3 150 2.03E-25 103 KLH26_DANRE reviewed Kelch-like protein 26 klhl26 si:ch211-255d18.7 Danio rerio (Zebrafish) (Brachydanio rerio) 605 protein ubiquitination [GO:0016567] GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q64336 CHOYP_TBR1.1.1 m.16741 sp TBR1_MOUSE 63.348 221 71 4 186 399 206 423 2.03E-91 298 TBR1_MOUSE reviewed T-box brain protein 1 (T-brain-1) (TBR-1) (TES-56) Tbr1 Mus musculus (Mouse) 681 amygdala development [GO:0021764]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; conditioned taste aversion [GO:0001661]; hindbrain development [GO:0030902]; neuron differentiation [GO:0030182]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of axon guidance [GO:1902667]; regulation of gene expression [GO:0010468]; regulation of neuron projection development [GO:0010975]; specification of organ identity [GO:0010092] GO:0000979; GO:0001077; GO:0001661; GO:0003677; GO:0003700; GO:0005634; GO:0010092; GO:0010468; GO:0010975; GO:0021764; GO:0021902; GO:0030182; GO:0030902; GO:0045944; GO:1902667 0 0 0 PF00907;PF16176; Q6DGN6 CHOYP_LOC100375375.1.1 m.45219 sp SPT2_DANRE 45.578 147 64 6 536 679 496 629 2.03E-16 86.7 SPT2_DANRE reviewed Protein SPT2 homolog (SPT2 domain-containing protein 1) spty2d1 zgc:111826 Danio rerio (Zebrafish) (Brachydanio rerio) 629 "histone exchange [GO:0043486]; nucleosome assembly [GO:0006334]; regulation of chromatin assembly [GO:0010847]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001042; GO:0003677; GO:0005730; GO:0006334; GO:0006351; GO:0006355; GO:0010847; GO:0042393; GO:0043486 0 0 0 PF08243; Q6JHU9 CHOYP_LOC101078373.1.1 m.42435 sp CBP_RAT 37.475 491 204 22 1 442 1 437 2.03E-46 179 CBP_RAT reviewed CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) 2442 "cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; histone acetylation [GO:0016573]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003682; GO:0003684; GO:0003713; GO:0004402; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0008283; GO:0016407; GO:0016573; GO:0016604; GO:0033613; GO:0034644; GO:0042975; GO:0043234; GO:0043426; GO:0045893; GO:0045944; GO:0046332; GO:0048511; GO:0060355; GO:0070555; GO:0098609; GO:1900087; GO:1901224 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q6PFY8 CHOYP_BRAFLDRAFT_84664.7.7 m.65487 sp TRI45_MOUSE 28.369 141 87 2 1 134 188 321 2.03E-08 59.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7B3 CHOYP_OSHV1_GP060.1.1 m.28284 sp Y002_OSHVF 98.204 167 3 0 1 167 1 167 2.03E-118 334 Y002_OSHVF reviewed Uncharacterized protein ORF2 ORF2 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 167 0 0 0 0 0 0 Q7T2V2 CHOYP_ST1E1.2.2 m.63293 sp ST1S3_DANRE 36.036 111 62 1 13 114 188 298 2.03E-17 78.6 ST1S3_DANRE reviewed Cytosolic sulfotransferase 3 (EC 2.8.2.-) (SULT1 ST3) sult1st3 Danio rerio (Zebrafish) (Brachydanio rerio) 301 catecholamine metabolic process [GO:0006584]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805] GO:0005737; GO:0006584; GO:0006805; GO:0008146; GO:0008202 0 0 0 PF00685; Q7Z0T3 CHOYP_ACDOPBH.1.9 m.8787 sp TEMPT_APLCA 50.435 115 55 2 1 114 7 120 2.03E-30 108 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q801E2 CHOYP_ANLN.1.1 m.6530 sp ANLN_XENLA 36.42 486 275 10 853 1312 639 1116 2.03E-95 335 ANLN_XENLA reviewed Actin-binding protein anillin anln Xenopus laevis (African clawed frog) 1116 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0005856; GO:0005938; GO:0007067; GO:0051301 0 0 0 PF08174;PF16018;PF00169; Q8BME9 CHOYP_CBLN14.1.2 m.23766 sp CBLN4_MOUSE 30.534 131 85 5 145 272 66 193 2.03E-06 50.8 CBLN4_MOUSE reviewed Cerebellin-4 (Cerebellin-like glycoprotein 1) Cbln4 Cblnl1 Mus musculus (Mouse) 198 protein secretion [GO:0009306] GO:0005615; GO:0009306; GO:0030054; GO:0045202 0 0 0 PF00386; Q8BX70 CHOYP_BRAFLDRAFT_88208.2.3 m.5321 sp VP13C_MOUSE 29.572 1356 791 35 2194 3504 2475 3711 2.03E-143 509 VP13C_MOUSE reviewed Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) 3748 mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0005741; GO:0005829; GO:0006623; GO:0007005; GO:0019898; GO:0045053; GO:0070062; GO:1905090 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q8HXW0 CHOYP_PNAP_0598.2.2 m.58528 sp GGLO_PIG 20.539 482 317 15 118 589 10 435 2.03E-11 70.1 GGLO_PIG reviewed L-gulonolactone oxidase (LGO) (EC 1.1.3.8) (L-gulono-gamma-lactone oxidase) (GLO) GULO Sus scrofa (Pig) 440 L-ascorbic acid biosynthetic process [GO:0019853] GO:0003885; GO:0005789; GO:0016021; GO:0019853; GO:0031090; GO:0050105; GO:0050660 PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 4/4. 0 0 PF04030;PF01565; Q8K2R5 CHOYP_BRAFLDRAFT_66750.1.1 m.46430 sp ZN668_MOUSE 26.225 408 232 15 405 759 4 395 2.03E-23 109 ZN668_MOUSE reviewed Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q8VI56 CHOYP_LRP4.2.5 m.2497 sp LRP4_MOUSE 27.325 871 564 23 5 842 514 1348 2.03E-84 300 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q96MM6 CHOYP_BRAFLDRAFT_208197.7.21 m.28833 sp HS12B_HUMAN 29.664 654 363 19 6 583 40 672 2.03E-90 296 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_57788.2.10 m.27928 sp HS12B_HUMAN 27.536 483 283 13 14 432 194 673 2.03E-54 195 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96PY6 CHOYP_LOC100061302.1.1 m.47172 sp NEK1_HUMAN 47.018 285 144 2 8 285 7 291 2.03E-81 285 NEK1_HUMAN reviewed Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) NEK1 KIAA1901 Homo sapiens (Human) 1258 cell division [GO:0051301]; cilium assembly [GO:0042384]; mitotic nuclear division [GO:0007067]; protein phosphorylation [GO:0006468] GO:0000242; GO:0004672; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0007067; GO:0016301; GO:0042384; GO:0046872; GO:0051301 0 0 0 PF00069; Q96RW7 CHOYP_LOC661200.1.3 m.26171 sp HMCN1_HUMAN 24.092 303 174 12 108 384 2921 3193 2.03E-07 58.5 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99K90 CHOYP_TAB3.1.1 m.25766 sp TAB2_MOUSE 40.513 195 83 7 500 690 526 691 2.03E-30 131 TAB2_MOUSE reviewed TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) Tab2 Kiaa0733 Map3k7ip2 Mus musculus (Mouse) 693 heart development [GO:0007507]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein kinase activity [GO:0045860] GO:0005654; GO:0005829; GO:0007507; GO:0008270; GO:0043123; GO:0045860; GO:0070530 0 0 0 PF02845; Q9D1I6 CHOYP_LOC100875089.1.1 m.26761 sp RM14_MOUSE 46.043 139 68 3 2 136 10 145 2.03E-35 122 RM14_MOUSE reviewed "39S ribosomal protein L14, mitochondrial (L14mt) (MRP-L14)" Mrpl14 Mus musculus (Mouse) 145 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005840; GO:0006412; GO:0044822 0 0 0 PF00238; Q9ESN6 CHOYP_BRAFLDRAFT_90331.1.2 m.27910 sp TRIM2_MOUSE 28.571 203 130 8 89 284 536 730 2.03E-09 61.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HCF6 CHOYP_TRPM3.5.7 m.38736 sp TRPM3_HUMAN 29.505 1332 750 34 44 1252 61 1326 2.03E-158 521 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9UBC3 CHOYP_LOC101175080.1.2 m.15233 sp DNM3B_HUMAN 25.831 391 234 13 208 556 176 552 2.03E-30 130 DNM3B_HUMAN reviewed DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) DNMT3B Homo sapiens (Human) 853 "cellular response to dexamethasone stimulus [GO:0071549]; cellular response to hyperoxia [GO:0071455]; DNA methylation [GO:0006306]; DNA methylation on cytosine within a CG sequence [GO:0010424]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of histone H3-K9 methylation [GO:0051573]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of neuron differentiation [GO:0045666]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethioninamine metabolic process [GO:0046499]" GO:0000122; GO:0001666; GO:0003682; GO:0003714; GO:0003886; GO:0005634; GO:0005654; GO:0005737; GO:0006306; GO:0009008; GO:0009636; GO:0010212; GO:0010424; GO:0010628; GO:0014823; GO:0031000; GO:0032355; GO:0033189; GO:0042220; GO:0042493; GO:0043231; GO:0045322; GO:0045666; GO:0045814; GO:0046498; GO:0046499; GO:0046872; GO:0051571; GO:0051573; GO:0051718; GO:0071455; GO:0071549 0 0 0 PF00145;PF00855; Q9Y6R7 CHOYP_FCGBP.2.4 m.29088 sp FCGBP_HUMAN 26.19 252 171 7 164 407 135 379 2.03E-15 83.2 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; F1ND48 CHOYP_BRAFLDRAFT_252309.2.2 m.19711 sp FBH1_CHICK 41.717 501 211 11 14 436 417 914 2.04E-106 340 FBH1_CHICK reviewed F-box DNA helicase 1 (EC 3.6.4.12) (F-box only protein 18) FBXO18 FBH1 FBX18 Gallus gallus (Chicken) 1012 "cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of chromatin binding [GO:0035562]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; replication fork protection [GO:0048478]; response to intra-S DNA damage checkpoint signaling [GO:0072429]" GO:0000724; GO:0000737; GO:0000785; GO:0001934; GO:0003678; GO:0003690; GO:0003697; GO:0004003; GO:0005524; GO:0005634; GO:0006974; GO:0008219; GO:0015616; GO:0016567; GO:0019005; GO:0031297; GO:0035562; GO:0043138; GO:0048478; GO:0072429; GO:1902231; GO:2000042 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8NFZ0}. 0 0 PF12937;PF13361; O18334 CHOYP_LOC661182.1.1 m.25729 sp RAB6_DROME 84.653 202 29 2 5 205 8 208 2.04E-121 345 RAB6_DROME reviewed Ras-related protein Rab6 (Protein warthog) Rab6 wrt CG6601 Drosophila melanogaster (Fruit fly) 208 "axon guidance [GO:0007411]; compound eye morphogenesis [GO:0001745]; defense response to fungus [GO:0050832]; exocytosis [GO:0006887]; germarium-derived egg chamber formation [GO:0007293]; intra-Golgi vesicle-mediated transport [GO:0006891]; oocyte microtubule cytoskeleton polarization [GO:0008103]; photoreceptor cell maintenance [GO:0045494]; phototransduction [GO:0007602]; pole plasm oskar mRNA localization [GO:0045451]; R7 cell development [GO:0045467]; Rab protein signal transduction [GO:0032482]; regulation of postsynaptic membrane potential [GO:0060078]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle-mediated transport [GO:0016192]" GO:0000139; GO:0001745; GO:0003924; GO:0005525; GO:0005794; GO:0005829; GO:0006887; GO:0006890; GO:0006891; GO:0007293; GO:0007411; GO:0007602; GO:0008103; GO:0016023; GO:0016192; GO:0030054; GO:0031982; GO:0032482; GO:0042147; GO:0043025; GO:0043204; GO:0045202; GO:0045451; GO:0045467; GO:0045494; GO:0050832; GO:0060078 0 0 0 PF00071; O35495 CHOYP_LOC657012.1.1 m.54792 sp CDK14_MOUSE 54.339 484 177 8 15 494 6 449 2.04E-170 492 CDK14_MOUSE reviewed Cyclin-dependent kinase 14 (EC 2.7.11.22) (Cell division protein kinase 14) (Serine/threonine-protein kinase PFTAIRE-1) Cdk14 Kiaa0834 Pftk1 Mus musculus (Mouse) 469 cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055] GO:0000086; GO:0000308; GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0016055; GO:0030332; GO:0051301; GO:0060828 0 0 0 PF00069; O35678 CHOYP_LOC100367289.1.1 m.14884 sp MGLL_MOUSE 36.101 277 169 3 14 289 25 294 2.04E-56 186 MGLL_MOUSE reviewed Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL) Mgll Mus musculus (Mouse) 303 acylglycerol catabolic process [GO:0046464]; arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; long term synaptic depression [GO:0060292]; regulation of axon extension [GO:0030516]; regulation of endocannabinoid signaling pathway [GO:2000124]; regulation of inflammatory response [GO:0050727]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; triglyceride catabolic process [GO:0019433] GO:0005654; GO:0005829; GO:0006633; GO:0009966; GO:0019369; GO:0019433; GO:0019898; GO:0030424; GO:0030516; GO:0042803; GO:0043196; GO:0045202; GO:0046464; GO:0047372; GO:0050727; GO:0051930; GO:0060292; GO:2000124 "PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. {ECO:0000269|PubMed:18096503, ECO:0000269|PubMed:9341166}." 0 0 PF12146; O73853 CHOYP_LOC100371043.2.5 m.15716 sp CP17A_ICTPU 36.728 324 202 3 43 365 180 501 2.04E-67 224 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; O75382 CHOYP_BRAFLDRAFT_88223.1.22 m.13475 sp TRIM3_HUMAN 21.98 505 340 14 66 544 115 591 2.04E-13 76.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88572 CHOYP_LRP6.4.6 m.24736 sp LRP6_MOUSE 32.453 265 169 4 26 288 327 583 2.04E-35 147 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; P13846 CHOYP_LOC100493440.2.2 m.56581 sp DPOL_HHBV 27.711 166 111 5 210 372 448 607 2.04E-08 60.1 DPOL_HHBV reviewed Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Heron hepatitis B virus (HHBV) 788 DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006260; GO:0046872 0 0 0 PF00336;PF00242;PF00078; P16157 CHOYP_AFUA_1G01020.33.50 m.43179 sp ANK1_HUMAN 37 200 111 4 769 968 341 525 2.04E-23 111 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17671 CHOYP_DANA_GF24303.1.1 m.33639 sp E75BC_DROME 64.634 82 28 1 79 159 245 326 2.04E-28 125 E75BC_DROME reviewed "Ecdysone-induced protein 75B, isoforms C/D (E75-A) (Nuclear receptor subfamily 1 group D member 3, isoforms C/D)" Eip75B NR1D3 CG8127 Drosophila melanogaster (Fruit fly) 1199 "antimicrobial humoral response [GO:0019730]; ecdysis, chitin-based cuticle [GO:0018990]; molting cycle, chitin-based cuticle [GO:0007591]; multicellular organism development [GO:0007275]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; oogenesis [GO:0048477]; regulation of ecdysteroid metabolic process [GO:0007553]; regulation of gene expression [GO:0010468]; regulation of glucose metabolic process [GO:0010906]; response to ecdysone [GO:0035075]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003707; GO:0004879; GO:0004887; GO:0005634; GO:0006351; GO:0007275; GO:0007553; GO:0007591; GO:0008270; GO:0010468; GO:0010906; GO:0018990; GO:0019730; GO:0020037; GO:0035075; GO:0043565; GO:0048477 0 0 0 PF00104;PF00105; P33573 CHOYP_LOC100656215.1.1 m.38344 sp FIBA2_PETMA 44.828 58 29 2 234 289 401 457 2.04E-07 55.5 FIBA2_PETMA reviewed Fibrinogen alpha-2 chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha-2 chain] 0 Petromyzon marinus (Sea lamprey) 641 platelet activation [GO:0030168]; protein polymerization [GO:0051258]; signal transduction [GO:0007165] GO:0005577; GO:0007165; GO:0030168; GO:0051258 0 0 0 PF08702;PF00147; P36241 CHOYP_contig_039310 m.44526 sp RL19_DROME 81.379 145 27 0 1 145 9 153 2.04E-82 243 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P40983 CHOYP_LOC100370751.1.4 m.51776 sp YOR6_CALSR 23.393 389 245 16 91 462 50 402 2.04E-10 66.6 YOR6_CALSR reviewed Uncharacterized protein in xynA 3'region (ORF6) (Fragment) 0 Caldicellulosiruptor sp. (strain Rt8B.4) 402 0 0 0 0 0 PF00350; P46088 CHOYP_GST7.1.1 m.59335 sp GST_NOTSL 40.196 204 112 2 1 200 1 198 2.04E-42 144 GST_NOTSL reviewed Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma) 0 Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei) 203 0 GO:0004364; GO:0005737 0 0 0 PF14497;PF02798; P50133 CHOYP_LOC100697568.1.1 m.54247 sp PTH1R_PIG 40.789 380 202 7 64 425 100 474 2.04E-86 280 PTH1R_PIG reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Sus scrofa (Pig) 585 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular calcium ion homeostasis [GO:0006874]; chondrocyte differentiation [GO:0002062]; negative regulation of cell proliferation [GO:0008285]; osteoblast development [GO:0002076]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cell proliferation [GO:0008284] GO:0002062; GO:0002076; GO:0004991; GO:0005622; GO:0005887; GO:0006874; GO:0007166; GO:0007188; GO:0007189; GO:0007200; GO:0008284; GO:0008285; GO:0017046; GO:0030282; GO:0043621; GO:0045453; GO:0048469; GO:0070062 0 0 0 PF00002;PF02793; Q01H84 CHOYP_LOC100709538.1.2 m.4300 sp SELN_XENTR 36.19 105 58 3 1 97 453 556 2.04E-09 56.2 SELN_XENTR reviewed Selenoprotein N (SelN) sepn1 TEgg073a06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 562 skeletal muscle fiber development [GO:0048741] GO:0005789; GO:0016021; GO:0016491; GO:0048741 0 0 0 0 Q06852 CHOYP_NEMVEDRAFT_V1G208691.9.10 m.46643 sp SLAP1_CLOTH 54.789 261 81 20 1 243 1524 1765 2.04E-09 60.8 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q08C93 CHOYP_ABHD12.1.1 m.6655 sp ABD12_DANRE 46.057 317 167 1 46 358 59 375 2.04E-107 322 ABD12_DANRE reviewed Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (Abhydrolase domain-containing protein 12) abhd12 si:ch211-79l10.2 zgc:153367 Danio rerio (Zebrafish) (Brachydanio rerio) 382 acylglycerol catabolic process [GO:0046464] GO:0016021; GO:0046464; GO:0047372 0 0 0 PF12146; Q0VGY8 CHOYP_LOC578974.4.11 m.24803 sp TANC1_MOUSE 44.262 122 68 0 1 122 1087 1208 2.04E-25 102 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q13231 CHOYP_BRAFLDRAFT_281651.8.8 m.47410 sp CHIT1_HUMAN 44.064 438 189 10 4 433 76 465 2.04E-117 360 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q21828 CHOYP_CRE_20365.1.3 m.20889 sp MPC1_CAEEL 57.843 102 42 1 13 114 26 126 2.04E-38 130 MPC1_CAEEL reviewed Probable mitochondrial pyruvate carrier 1 (MPC1) R07E5.13 Caenorhabditis elegans 137 mitochondrial pyruvate transport [GO:0006850] GO:0005743; GO:0006850; GO:0016021 0 0 0 PF03650; Q3S8M4 CHOYP_ELOV4.1.3 m.25113 sp ELOV4_MACMU 53.925 293 127 1 1 293 12 296 2.04E-114 335 ELOV4_MACMU reviewed Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) ELOVL4 Macaca mulatta (Rhesus macaque) 314 "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" GO:0005783; GO:0006636; GO:0009922; GO:0019367; GO:0030148; GO:0030176; GO:0034625; GO:0034626; GO:0035338; GO:0042761; GO:0102336; GO:0102337; GO:0102338 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03204}. 0 0 PF01151; Q460N5 CHOYP_PAR14.15.17 m.60686 sp PAR14_HUMAN 30.67 388 244 11 335 717 774 1141 2.04E-36 153 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q56A24 CHOYP_KLH24.4.6 m.53748 sp KLH24_RAT 26 550 334 18 34 544 47 562 2.04E-38 152 KLH24_RAT reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) Klhl24 Dre1 Rattus norvegicus (Rat) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q5R7K7 CHOYP_LOC100214006.1.1 m.52585 sp SENP2_PONAB 24.224 161 111 2 5 154 397 557 2.04E-07 54.7 SENP2_PONAB reviewed Sentrin-specific protease 2 (EC 3.4.22.68) (Sentrin/SUMO-specific protease SENP2) SENP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 589 fat cell differentiation [GO:0045444]; mRNA transport [GO:0051028]; protein desumoylation [GO:0016926]; protein transport [GO:0015031]; Wnt signaling pathway [GO:0016055] GO:0005643; GO:0005737; GO:0015031; GO:0016055; GO:0016926; GO:0016929; GO:0031965; GO:0045444; GO:0051028 0 0 0 PF02902; Q5T2D3 CHOYP_LOC755749.1.1 m.61368 sp OTUD3_HUMAN 43.575 358 178 8 29 378 22 363 2.04E-84 266 OTUD3_HUMAN reviewed OTU domain-containing protein 3 (EC 3.4.19.12) OTUD3 KIAA0459 Homo sapiens (Human) 398 protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313] GO:0004843; GO:0035871; GO:0044313 0 0 0 PF02338; Q5XK91 CHOYP_LOC100367879.2.3 m.24203 sp FBCDB_XENLA 43.379 219 113 6 351 562 239 453 2.04E-50 183 FBCDB_XENLA reviewed Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) 457 0 GO:0008061; GO:0016021; GO:0046872 0 0 0 PF00147; Q6GMK0 CHOYP_MGT4B.1.1 m.64401 sp MGT4B_DANRE 47.101 552 275 8 1 542 1 545 2.04E-179 519 MGT4B_DANRE reviewed "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb) (GlcNAc-T IVb) (GnT-IVb) (N-acetylglucosaminyltransferase IVb) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb)" mgat4b zgc:92425 Danio rerio (Zebrafish) (Brachydanio rerio) 547 N-glycan processing [GO:0006491] GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04666; Q6PUR6 CHOYP_GPN2.1.1 m.16188 sp GPN2_DANRE 66.441 295 99 0 2 296 11 305 2.04E-147 419 GPN2_DANRE reviewed GPN-loop GTPase 2 (ATP-binding domain 1 family member B) gpn2 atpbd1b zgc:92877 Danio rerio (Zebrafish) (Brachydanio rerio) 311 0 GO:0005525; GO:0016787 0 0 0 PF03029; Q6ZTW0 CHOYP_TYRO.1.1 m.38877 sp TPGS1_HUMAN 30.078 256 157 5 13 247 33 287 2.04E-35 130 TPGS1_HUMAN reviewed Tubulin polyglutamylase complex subunit 1 (PGs1) TPGS1 C19orf20 Homo sapiens (Human) 290 adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; protein polyglutamylation [GO:0018095]; sperm axoneme assembly [GO:0007288]; vesicle localization [GO:0051648] GO:0005737; GO:0005813; GO:0005874; GO:0007268; GO:0007275; GO:0007288; GO:0018095; GO:0030424; GO:0030425; GO:0030534; GO:0031514; GO:0051648; GO:0070740 0 0 0 0 Q80T91 CHOYP_MEG11.12.25 m.43826 sp MEG11_MOUSE 37.427 513 285 23 189 692 220 705 2.04E-71 255 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q80VI1 CHOYP_NEMVEDRAFT_V1G193373.1.2 m.19292 sp TRI56_MOUSE 23.81 315 191 10 48 343 17 301 2.04E-15 83.6 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q8AVY1 CHOYP_LOC100368464.2.2 m.45783 sp ODF3A_XENLA 53.782 119 55 0 5 123 135 253 2.04E-37 130 ODF3A_XENLA reviewed Outer dense fiber protein 3 (Outer dense fiber of sperm tails protein 3) odf3 Xenopus laevis (African clawed frog) 256 0 GO:0005737 0 0 0 PF07004; Q8BV66 CHOYP_LOC100150009.1.1 m.57630 sp IFI44_MOUSE 25.896 251 162 7 48 290 180 414 2.04E-12 70.5 IFI44_MOUSE reviewed Interferon-induced protein 44 (Microtubule-associated protein 44) Ifi44 Mtap44 Mus musculus (Mouse) 422 0 GO:0005737 0 0 0 PF07534; Q8C8R3 CHOYP_LOC100197555.5.7 m.57345 sp ANK2_MOUSE 29.787 752 425 6 6 654 63 814 2.04E-99 338 ANK2_MOUSE reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) Ank2 Mus musculus (Mouse) 3898 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; cardiac muscle contraction [GO:0060048]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cation channel activity [GO:2001257]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of SA node cell action potential [GO:0098907]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; T-tubule organization [GO:0033292] GO:0002027; GO:0005622; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0006874; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014069; GO:0014704; GO:0015459; GO:0016324; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0048471; GO:0050821; GO:0051117; GO:0051924; GO:0051928; GO:0055117; GO:0060048; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086014; GO:0086015; GO:0086036; GO:0086066; GO:0086070; GO:0086091; GO:0098904; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001257; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q91756 CHOYP_LOC100900429.1.1 m.13158 sp GLRK_XENLA 28.704 432 274 11 20 441 41 448 2.04E-55 194 GLRK_XENLA reviewed Glutamate receptor U1 (Kainate-binding protein) (Unitary non-NMDA glutamate receptor subunit 1) (XENU1) kbp Xenopus laevis (African clawed frog) 479 0 GO:0004970; GO:0005234; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF00060;PF10613; Q95K40 CHOYP_LOC100371909.1.1 m.30746 sp CCD83_MACFA 30.402 398 254 5 9 399 3 384 2.04E-43 160 CCD83_MACFA reviewed Coiled-coil domain-containing protein 83 CCDC83 QtsA-10152 QtsA-19320 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 413 0 0 0 0 0 0 Q95K40 CHOYP_LOC584368.1.2 m.10627 sp CCD83_MACFA 30.402 398 254 5 9 399 3 384 2.04E-43 160 CCD83_MACFA reviewed Coiled-coil domain-containing protein 83 CCDC83 QtsA-10152 QtsA-19320 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 413 0 0 0 0 0 0 Q99315 CHOYP_contig_006588 m.7499 sp YG31B_YEAST 26.51 894 562 24 439 1263 587 1454 2.04E-77 286 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9BHM6 CHOYP_OCDH.1.1 m.1284 sp OCDH_PECMA 43.609 399 220 4 6 402 3 398 2.04E-128 378 OCDH_PECMA reviewed Octopine dehydrogenase (OcDH) (EC 1.5.1.11) odh1 Pecten maximus (King scallop) (Pilgrim's clam) 399 0 GO:0000166; GO:0047830; GO:0050662 0 0 0 PF02317; Q9EQQ9 CHOYP_LOC100378403.1.1 m.26209 sp OGA_MOUSE 41.991 231 130 3 26 255 689 916 2.04E-50 179 OGA_MOUSE reviewed Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Bifunctional protein NCOAT) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) Mgea5 Hexc Kiaa0679 Mus musculus (Mouse) 916 glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517] GO:0005634; GO:0005829; GO:0006044; GO:0006517; GO:0009100; GO:0016020; GO:0016231 0 0 0 PF07555; Q9ER75 CHOYP_IRO.1.4 m.6320 sp IRX6_MOUSE 63.158 114 41 1 90 203 106 218 2.04E-40 152 IRX6_MOUSE reviewed Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6) Irx6 Irxb3 Mus musculus (Mouse) 438 "detection of visible light [GO:0009584]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; retina layer formation [GO:0010842]; retinal bipolar neuron differentiation [GO:0060040]" GO:0001227; GO:0001228; GO:0005634; GO:0009584; GO:0010842; GO:0043565; GO:0045892; GO:0045893; GO:0060040 0 0 0 PF05920; Q9I8T7 CHOYP_LOC411534.1.2 m.35550 sp BMAL1_CHICK 23.98 392 243 11 19 368 71 449 2.04E-21 102 BMAL1_CHICK reviewed Aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1b') (Brain and muscle ARNT-like 1) (cBMAL1) ARNTL BMAL1 Gallus gallus (Chicken) 633 "circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; maternal process involved in parturition [GO:0060137]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of TOR signaling [GO:0032007]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of skeletal muscle cell differentiation [GO:2001016]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein import into nucleus, translocation [GO:0000060]; regulation of cell cycle [GO:0051726]; regulation of cellular senescence [GO:2000772]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of protein catabolic process [GO:0042176]; regulation of type B pancreatic cell development [GO:2000074]; response to redox state [GO:0051775]; spermatogenesis [GO:0007283]" GO:0000060; GO:0000982; GO:0001046; GO:0001190; GO:0003677; GO:0005667; GO:0007283; GO:0007623; GO:0016605; GO:0032007; GO:0032922; GO:0033391; GO:0042176; GO:0042753; GO:0043161; GO:0045599; GO:0045893; GO:0050767; GO:0050796; GO:0051726; GO:0051775; GO:0060137; GO:0070888; GO:0090263; GO:0090403; GO:2000074; GO:2000323; GO:2000772; GO:2001016 0 0 0 PF00010;PF00989; Q9N285 CHOYP_LOC100377398.1.1 m.44441 sp MTCH2_BOVIN 37.847 288 169 4 2 280 1 287 2.04E-64 208 MTCH2_BOVIN reviewed Mitochondrial carrier homolog 2 MTCH2 Bos taurus (Bovine) 303 positive regulation of apoptotic process [GO:0043065]; transport [GO:0006810] GO:0005739; GO:0005743; GO:0006810; GO:0016020; GO:0016021; GO:0043065 0 0 0 PF00153; Q9QUN7 CHOYP_LOC101387492.1.1 m.54690 sp TLR2_MOUSE 37.624 101 61 2 14 112 641 741 2.04E-10 66.2 TLR2_MOUSE reviewed Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) 784 cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to peptidoglycan [GO:0071224]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; chloramphenicol transport [GO:0042892]; cytokine secretion involved in immune response [GO:0002374]; defense response to Gram-positive bacterium [GO:0050830]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; induction by symbiont of defense-related host nitric oxide production [GO:0052063]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-10 production [GO:0032613]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-17 production [GO:0032700]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of xenophagy [GO:1904417]; regulation of dendritic cell cytokine production [GO:0002730]; response to bacterium [GO:0009617]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; toll-like receptor 2 signaling pathway [GO:0034134] GO:0001530; GO:0002238; GO:0002374; GO:0002687; GO:0002730; GO:0002752; GO:0002755; GO:0004872; GO:0004888; GO:0005737; GO:0005794; GO:0005886; GO:0006954; GO:0007252; GO:0008329; GO:0009617; GO:0009897; GO:0009986; GO:0010628; GO:0016021; GO:0030177; GO:0030670; GO:0031226; GO:0032494; GO:0032613; GO:0032695; GO:0032700; GO:0032722; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0032757; GO:0032760; GO:0034123; GO:0034134; GO:0035325; GO:0035354; GO:0035355; GO:0042346; GO:0042495; GO:0042496; GO:0042497; GO:0042498; GO:0042535; GO:0042834; GO:0042892; GO:0044130; GO:0045087; GO:0045121; GO:0045429; GO:0045944; GO:0046982; GO:0050715; GO:0050729; GO:0050830; GO:0051092; GO:0051770; GO:0052063; GO:0060907; GO:0070374; GO:0070891; GO:0071221; GO:0071223; GO:0071224; GO:0071726; GO:0071727; GO:1901224; GO:1904417 0 0 0 PF13516;PF13855;PF01582; Q9U4L6 CHOYP_DPSE_GA11443.1.1 m.19526 sp TO401_DROME 49.833 299 142 4 55 352 53 344 2.04E-104 313 TO401_DROME reviewed Mitochondrial import receptor subunit TOM40 homolog 1 (dtom40) (Male sterile protein 15) (Translocase of outer membrane 40 kDa subunit homolog 1) Tom40 mit ms(1)15 CG12157 Drosophila melanogaster (Fruit fly) 344 cellular response to hypoxia [GO:0071456]; ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626] GO:0005739; GO:0005742; GO:0006626; GO:0006811; GO:0015266; GO:0015288; GO:0030150; GO:0046930; GO:0071456 0 0 0 PF01459; Q9VUX2 CHOYP_BRAFLDRAFT_120990.6.18 m.37472 sp MIB_DROME 44.928 69 36 1 342 410 108 174 2.04E-08 61.2 MIB_DROME reviewed E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) 1226 endocytosis [GO:0006897]; lateral inhibition [GO:0046331]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; sensory organ development [GO:0007423] GO:0000209; GO:0004842; GO:0005737; GO:0005829; GO:0006897; GO:0007219; GO:0007423; GO:0008104; GO:0008270; GO:0008593; GO:0016567; GO:0016874; GO:0045179; GO:0045747; GO:0046331; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q9Y5K3 CHOYP_LOC100907181.1.1 m.33340 sp PCY1B_HUMAN 54.704 287 110 4 22 292 39 321 2.04E-114 339 PCY1B_HUMAN reviewed Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) 369 ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid biosynthetic process [GO:0008654]; spermatogenesis [GO:0007283] GO:0001541; GO:0004105; GO:0005737; GO:0005789; GO:0006656; GO:0007283; GO:0008654 PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. {ECO:0000250|UniProtKB:P19836}. 0 0 PF01467; Q9Y6N9 CHOYP_USH1C.1.1 m.30582 sp USH1C_HUMAN 44.147 299 159 5 8 302 5 299 2.04E-80 258 USH1C_HUMAN reviewed Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) USH1C AIE75 Homo sapiens (Human) 552 brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; cellular protein complex assembly [GO:0043623]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; regulation of microvillus length [GO:0032532]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0000086; GO:0001750; GO:0001917; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005902; GO:0005903; GO:0007605; GO:0030154; GO:0030507; GO:0032420; GO:0032532; GO:0043623; GO:0045177; GO:0045202; GO:0045494; GO:0050953; GO:0050957; GO:1904106; GO:1904970 0 0 0 PF00595; A4IF63 CHOYP_BRAFLDRAFT_120965.1.1 m.35418 sp TRIM2_BOVIN 25 156 111 3 380 530 590 744 2.05E-07 57.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_69765.8.23 m.32817 sp TRIM2_BOVIN 27.143 210 141 7 313 515 540 744 2.05E-10 67 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8MT70 CHOYP_LOC100892912.1.1 m.8405 sp ZBBX_HUMAN 30.117 342 197 11 16 344 17 329 2.05E-30 132 ZBBX_HUMAN reviewed Zinc finger B-box domain-containing protein 1 ZBBX Homo sapiens (Human) 800 0 GO:0005622; GO:0008270 0 0 0 PF00643; D2GXS7 CHOYP_LOC100369929.1.5 m.32679 sp TRIM2_AILME 23.256 215 150 6 51 252 492 704 2.05E-06 52 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F4JTP5 CHOYP_BRAFLDRAFT_81321.4.10 m.40782 sp STY46_ARATH 27.536 276 158 13 49 318 296 535 2.05E-22 101 STY46_ARATH reviewed Serine/threonine-protein kinase STY46 (EC 2.7.11.1) (Serine/threonine/tyrosine-protein kinase 46) STY46 At4g38470 F20M13.30 Arabidopsis thaliana (Mouse-ear cress) 575 chloroplast organization [GO:0009658] GO:0004674; GO:0004712; GO:0005524; GO:0005829; GO:0009658; GO:0016597 0 0 0 PF01842;PF07714; O13008 CHOYP_LOC101156833.1.1 m.38739 sp FABPH_ONCMY 38.806 134 78 3 6 138 1 131 2.05E-23 91.7 FABPH_ONCMY reviewed "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP)" fabp3 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 133 0 GO:0005215; GO:0005737; GO:0008289 0 0 0 PF00061; O14562 CHOYP_HS90A.1.3 m.7725 sp UBFD1_HUMAN 57.955 264 98 4 21 284 59 309 2.05E-104 309 UBFD1_HUMAN reviewed Ubiquitin domain-containing protein UBFD1 (Ubiquitin-binding protein homolog) UBFD1 UBPH Homo sapiens (Human) 309 0 GO:0005913; GO:0044822; GO:0098641 0 0 0 PF00240; O15050 CHOYP_BRAFLDRAFT_68257.1.1 m.65292 sp TRNK1_HUMAN 23.582 335 214 11 1 326 1774 2075 2.05E-09 64.3 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O50655 CHOYP_LOC100632495.2.11 m.7784 sp XERD_SELRU 28.07 285 187 9 29 307 45 317 2.05E-19 90.5 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O97039 CHOYP_LOC100313708.1.1 m.9150 sp RX_DUGJA 40.667 150 81 3 77 222 88 233 2.05E-25 103 RX_DUGJA reviewed Retinal homeobox protein Rax (DjRax) (Fragment) RAX Dugesia japonica (Planarian) 268 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; P10041 CHOYP_VDAC2.1.2 m.21870 sp DL_DROME 53.077 130 61 0 6 135 439 568 2.05E-39 149 DL_DROME reviewed Neurogenic locus protein delta Dl CG3619 Drosophila melanogaster (Fruit fly) 833 "actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; asymmetric cell division [GO:0008356]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye retinal cell programmed cell death [GO:0046667]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; ectoderm development [GO:0007398]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; germ-line stem cell population maintenance [GO:0030718]; glial cell migration [GO:0008347]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; R3/R4 cell fate commitment [GO:0007464]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of R8 cell spacing in compound eye [GO:0045468]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]; stem cell differentiation [GO:0048863]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]" GO:0001708; GO:0001736; GO:0005102; GO:0005112; GO:0005509; GO:0005768; GO:0005886; GO:0005912; GO:0007015; GO:0007155; GO:0007219; GO:0007298; GO:0007314; GO:0007398; GO:0007399; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007451; GO:0007460; GO:0007464; GO:0007474; GO:0007475; GO:0007476; GO:0007480; GO:0007498; GO:0008284; GO:0008347; GO:0008356; GO:0008407; GO:0008586; GO:0009986; GO:0016021; GO:0016318; GO:0016330; GO:0019233; GO:0030139; GO:0030431; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0031410; GO:0035003; GO:0035155; GO:0035157; GO:0036011; GO:0042067; GO:0042676; GO:0045465; GO:0045468; GO:0045931; GO:0046331; GO:0046667; GO:0048190; GO:0048477; GO:0048749; GO:0048800; GO:0048863; GO:0050768 0 0 0 PF01414;PF00008;PF12661;PF07657; P16157 CHOYP_TVAG_123950.29.31 m.65417 sp ANK1_HUMAN 32.73 663 415 2 242 875 77 737 2.05E-108 372 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P28828 CHOYP_PTPRM.13.15 m.54418 sp PTPRM_MOUSE 36.334 622 356 17 1119 1727 858 1452 2.05E-104 372 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P46778 CHOYP_TSP_04780.1.1 m.40489 sp RL21_HUMAN 68.354 158 50 0 1 158 1 158 2.05E-73 226 RL21_HUMAN reviewed 60S ribosomal protein L21 RPL21 Homo sapiens (Human) 160 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01157; P55937 CHOYP_LOC100377065.1.1 m.53443 sp GOGA3_MOUSE 27.624 1086 732 11 515 1571 407 1467 2.05E-97 349 GOGA3_MOUSE reviewed Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2) Golga3 Mea2 Mus musculus (Mouse) 1487 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0000139; GO:0005634; GO:0005654; GO:0005730; GO:0005793; GO:0005794; GO:0005829; GO:0007275; GO:0007283; GO:0016020; GO:0017119; GO:0030154; GO:0032580; GO:0090498 0 0 0 0 P84903 CHOYP_STIM1.1.1 m.13316 sp STIM1_RAT 45.738 481 238 9 58 525 55 525 2.05E-124 388 STIM1_RAT reviewed Stromal interaction molecule 1 Stim1 Sim Rattus norvegicus (Rat) 685 activation of store-operated calcium channel activity [GO:0032237]; cellular calcium ion homeostasis [GO:0006874]; detection of calcium ion [GO:0005513]; enamel mineralization [GO:0070166]; regulation of calcium ion transport [GO:0051924]; regulation of store-operated calcium entry [GO:2001256]; store-operated calcium entry [GO:0002115] GO:0002115; GO:0005246; GO:0005509; GO:0005513; GO:0005783; GO:0005874; GO:0005886; GO:0005887; GO:0006874; GO:0015279; GO:0030176; GO:0030426; GO:0032237; GO:0033017; GO:0051010; GO:0051924; GO:0070166; GO:2001256 0 0 cd11722; PF07647;PF16533; P97570 CHOYP_LOC100121363.1.1 m.46369 sp PLPL9_RAT 37.118 819 460 14 42 840 21 804 2.05E-172 521 PLPL9_RAT reviewed 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9) Pla2g6 Pnpla9 Rattus norvegicus (Rat) 807 "antibacterial humoral response [GO:0019731]; cardiolipin acyl-chain remodeling [GO:0035965]; cardiolipin biosynthetic process [GO:0032049]; chemotaxis [GO:0006935]; lipid catabolic process [GO:0016042]; maternal process involved in female pregnancy [GO:0060135]; memory [GO:0007613]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of vasodilation [GO:0045909]; regulation of store-operated calcium channel activity [GO:1901339]; response to endoplasmic reticulum stress [GO:0034976]; urinary bladder smooth muscle contraction [GO:0014832]" GO:0001934; GO:0004623; GO:0005615; GO:0005739; GO:0005743; GO:0005815; GO:0005829; GO:0006935; GO:0007204; GO:0007613; GO:0014832; GO:0016042; GO:0019731; GO:0019901; GO:0032049; GO:0034976; GO:0035774; GO:0035965; GO:0043008; GO:0045909; GO:0045921; GO:0047499; GO:0051967; GO:0060135; GO:0090037; GO:0090200; GO:0090238; GO:1901339; GO:2000304 0 0 0 PF12796;PF13606;PF01734; Q0VDD8 CHOYP_LOC591790.1.1 m.62131 sp DYH14_HUMAN 40.909 110 52 3 359 465 251 350 2.05E-18 95.5 DYH14_HUMAN reviewed "Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)" DNAH14 C1orf67 Homo sapiens (Human) 3507 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0007018; GO:0030286 0 0 0 PF12780;PF03028;PF12777; Q15256 CHOYP_LOC100374454.1.1 m.1320 sp PTPRR_HUMAN 39.785 558 300 13 121 657 110 652 2.05E-118 371 PTPRR_HUMAN reviewed Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) PTPRR ECPTP PTPRQ Homo sapiens (Human) 657 ERBB2 signaling pathway [GO:0038128]; in utero embryonic development [GO:0001701]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; neuron differentiation [GO:0030182]; protein dephosphorylation [GO:0006470] GO:0001701; GO:0004725; GO:0005001; GO:0005615; GO:0005737; GO:0005886; GO:0006470; GO:0010633; GO:0016021; GO:0019901; GO:0030054; GO:0030182; GO:0038128; GO:0048471; GO:0070373 0 0 0 PF00102; Q3SWY8 CHOYP_ZUFSP.1.1 m.42945 sp ZUFSP_BOVIN 26.923 130 94 1 23 151 4 133 2.05E-09 63.2 ZUFSP_BOVIN reviewed Zinc finger with UFM1-specific peptidase domain protein ZUFSP Bos taurus (Bovine) 579 0 GO:0046872 0 0 0 PF07910; Q495B1 CHOYP_TVAG_291510.1.9 m.364 sp AKD1A_HUMAN 31.897 232 120 7 1479 1692 150 361 2.05E-17 91.3 AKD1A_HUMAN reviewed Ankyrin repeat and death domain-containing protein 1A ANKDD1A Homo sapiens (Human) 522 signal transduction [GO:0007165] GO:0007165 0 0 0 PF00023;PF12796; Q568K2 CHOYP_PP1RB.2.2 m.63258 sp PP1RB_DANRE 48.889 90 38 4 1 84 1 88 2.05E-18 77.4 PP1RB_DANRE reviewed Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) 122 negative regulation of phosphoprotein phosphatase activity [GO:0032515] GO:0000164; GO:0004865; GO:0005634; GO:0032515 0 0 0 PF07491; Q5RDC3 CHOYP_LOC100563309.1.2 m.206 sp TF3C2_PONAB 26.165 665 416 20 412 1037 238 866 2.05E-43 174 TF3C2_PONAB reviewed General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC subunit beta) GTF3C2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 911 "transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351 0 0 0 PF00400; Q5W0Q7 CHOYP_USPL1.1.1 m.56370 sp USPL1_HUMAN 29.112 529 254 14 3 482 42 498 2.05E-56 214 USPL1_HUMAN reviewed SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) USPL1 C13orf22 D13S106 Homo sapiens (Human) 1092 Cajal body organization [GO:0030576]; cell proliferation [GO:0008283]; protein desumoylation [GO:0016926] GO:0005615; GO:0008283; GO:0015030; GO:0016926; GO:0030576; GO:0032183; GO:0070140 0 0 0 PF15509;PF15499; Q5XIH7 CHOYP_ISCW_ISCW021457.1.1 m.31134 sp PHB2_RAT 68.814 295 86 4 4 292 3 297 2.05E-144 410 PHB2_RAT reviewed Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37) Phb2 Bcap37 Rattus norvegicus (Rat) 299 "mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein import into nucleus, translocation [GO:0000060]; protein stabilization [GO:0050821]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; sister chromatid cohesion [GO:0007062]; transcription, DNA-templated [GO:0006351]" GO:0000060; GO:0005634; GO:0005739; GO:0005741; GO:0005743; GO:0006351; GO:0007005; GO:0007062; GO:0009986; GO:0016363; GO:0031536; GO:0033147; GO:0033218; GO:0033600; GO:0043066; GO:0043234; GO:0043433; GO:0045892; GO:0050821; GO:0051091; GO:0060744; GO:0060749; GO:0060762; GO:0070062; GO:0070374; GO:0071944; GO:1902808 0 0 cd03401; PF01145; Q5ZJR3 CHOYP_AGAP_AGAP008475.1.1 m.2006 sp OSTC_CHICK 65.217 115 39 1 5 119 1 114 2.05E-51 162 OSTC_CHICK reviewed Oligosaccharyltransferase complex subunit OSTC OSTC RCJMB04_16e19 Gallus gallus (Chicken) 149 0 GO:0008250; GO:0016021 0 0 0 PF04756; Q6AZB8 CHOYP_LOC100573409.1.2 m.37240 sp HARB1_DANRE 40.708 113 64 1 5 114 161 273 2.05E-22 93.2 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6DCG4 CHOYP_LOC100370684.2.2 m.66087 sp RHBGB_XENLA 48.649 444 201 5 14 452 17 438 2.05E-145 427 RHBGB_XENLA reviewed Ammonium transporter Rh type B-B (Rhesus blood group family type B glycoprotein B) (Rh family type B glycoprotein B) (Rh type B glycoprotein B) rhbg-b Xenopus laevis (African clawed frog) 460 0 GO:0008519; GO:0016021; GO:0016323; GO:0030659 0 0 0 PF00909; Q6H236 CHOYP_NEMVEDRAFT_V1G85477.1.1 m.64999 sp PEG3_BOVIN 35.789 190 122 0 2 191 1274 1463 2.05E-16 81.6 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6P9K9 CHOYP_LOC100720440.2.2 m.67004 sp NRX3A_MOUSE 26.636 214 138 9 38 248 252 449 2.05E-11 67.4 NRX3A_MOUSE reviewed Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) Nrxn3 Mus musculus (Mouse) 1571 adult behavior [GO:0030534]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; learning [GO:0007612]; neurotransmitter secretion [GO:0007269]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] GO:0005246; GO:0007155; GO:0007268; GO:0007269; GO:0007416; GO:0007612; GO:0016021; GO:0030534; GO:0035176; GO:0042734; GO:0043234; GO:0046872; GO:0051965; GO:0071625; GO:0090129 0 0 0 PF00008;PF02210;PF01034; Q6RFL5 CHOYP_BSH.1.1 m.63206 sp BSH_CHICK 58.824 170 51 7 11 167 14 177 2.05E-51 170 BSH_CHICK reviewed Brain-specific homeobox protein homolog BSX Gallus gallus (Chicken) 233 brain development [GO:0007420]; eating behavior [GO:0042755]; locomotory behavior [GO:0007626] GO:0000978; GO:0001077; GO:0005634; GO:0005667; GO:0005737; GO:0007420; GO:0007626; GO:0042755 0 0 0 PF00046; Q7ZUC7 CHOYP_PHUM_PHUM580720.1.1 m.14624 sp PGES2_DANRE 40.449 356 194 8 34 384 28 370 2.05E-78 249 PGES2_DANRE reviewed Prostaglandin E synthase 2 (EC 5.3.99.3) (Microsomal prostaglandin E synthase 2) (mPGES-2) ptges2 pges2 ptgesl Danio rerio (Zebrafish) (Brachydanio rerio) 377 cell redox homeostasis [GO:0045454]; prostaglandin biosynthetic process [GO:0001516] GO:0000139; GO:0001516; GO:0009055; GO:0015035; GO:0016021; GO:0016829; GO:0020037; GO:0043295; GO:0045454; GO:0050220 PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000250|UniProtKB:Q66LN0}. 0 0 PF00462;PF00043; Q8AWB5 CHOYP_LOC100369391.1.1 m.17514 sp FUT10_CHICK 44.323 458 228 9 11 451 14 461 2.05E-133 396 FUT10_CHICK reviewed "Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)" FUT10 Gallus gallus (Chicken) 475 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0032580; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q8BJK1 CHOYP_KCTD7.1.1 m.51291 sp KCTD7_MOUSE 36.25 240 126 6 11 240 47 269 2.05E-38 139 KCTD7_MOUSE reviewed BTB/POZ domain-containing protein KCTD7 Kctd7 Mus musculus (Mouse) 289 protein homooligomerization [GO:0051260] GO:0005829; GO:0005886; GO:0051260 0 0 0 PF02214; Q8BLY1 CHOYP_LOC100374767.2.3 m.11986 sp SMOC1_MOUSE 30.847 295 164 7 269 534 175 458 2.05E-32 132 SMOC1_MOUSE reviewed SPARC-related modular calcium-binding protein 1 (SPARC-related gene protein) (Secreted modular calcium-binding protein 1) (SMOC-1) Smoc1 Srg Mus musculus (Mouse) 463 cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; limb development [GO:0060173]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of osteoblast differentiation [GO:0045667]; signal transduction [GO:0007165] GO:0001654; GO:0005509; GO:0005604; GO:0007165; GO:0010811; GO:0030154; GO:0030198; GO:0045667; GO:0050840; GO:0060173 0 0 0 PF07648;PF10591;PF00086; Q8IWY4 CHOYP_TRIADDRAFT_54447.1.1 m.14467 sp SCUB1_HUMAN 35.659 387 195 15 21 361 24 402 2.05E-48 188 SCUB1_HUMAN reviewed "Signal peptide, CUB and EGF-like domain-containing protein 1" SCUBE1 Homo sapiens (Human) 988 adult heart development [GO:0007512]; blood coagulation [GO:0007596]; endothelial cell differentiation [GO:0045446]; inflammatory response [GO:0006954]; post-embryonic development [GO:0009791]; protein homooligomerization [GO:0051260] GO:0005509; GO:0005615; GO:0006954; GO:0007512; GO:0007596; GO:0009791; GO:0009897; GO:0009986; GO:0019897; GO:0042802; GO:0045446; GO:0046982; GO:0051260 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.23.34 m.54629 sp VWDE_HUMAN 29.384 211 129 6 199 400 402 601 2.05E-16 88.2 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8Q0U0 CHOYP_RAI14.1.1 m.38328 sp Y045_METMA 33.14 172 111 2 49 220 158 325 2.05E-18 87.4 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q8QFX1 CHOYP_RIMB2.1.5 m.5272 sp RIMB2_CHICK 56.25 192 71 3 1191 1382 1113 1291 2.05E-59 228 RIMB2_CHICK reviewed RIMS-binding protein 2 (RIM-BP2) RIMBP2 RBP2 Gallus gallus (Chicken) 1325 negative regulation of phosphatase activity [GO:0010923] GO:0005886; GO:0010923; GO:0030054; GO:0045202 0 0 0 PF07653;PF14604; Q8TBF5 CHOYP_PIGX.1.1 m.43474 sp PIGX_HUMAN 35.122 205 122 6 73 269 41 242 2.05E-25 104 PIGX_HUMAN reviewed Phosphatidylinositol-glycan biosynthesis class X protein (PIG-X) PIGX Homo sapiens (Human) 258 preassembly of GPI anchor in ER membrane [GO:0016254] GO:0005789; GO:0016021; GO:0016254 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF08320; Q8WYQ5 CHOYP_AGAP_AGAP002554.1.1 m.59025 sp DGCR8_HUMAN 40.388 619 298 16 221 780 167 773 2.05E-133 417 DGCR8_HUMAN reviewed Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8) DGCR8 C22orf12 DGCRK6 LP4941 Homo sapiens (Human) 773 "gene silencing by RNA [GO:0031047]; primary miRNA processing [GO:0031053]; regulation of stem cell proliferation [GO:0072091]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]" GO:0003725; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0015630; GO:0020037; GO:0031047; GO:0031053; GO:0042803; GO:0046872; GO:0070877; GO:0070878; GO:0072091; GO:0090502 0 0 0 PF00035; Q96KG7 CHOYP_CED1.11.29 m.32056 sp MEG10_HUMAN 39.726 146 79 6 170 315 523 659 2.05E-15 82 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q96MM6 CHOYP_NEMVEDRAFT_V1G212312.4.5 m.54669 sp HS12B_HUMAN 37.821 156 87 5 127 280 64 211 2.05E-25 108 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99KF0 CHOYP_LOC100486738.1.2 m.63464 sp CAR14_MOUSE 22.751 778 490 30 6 732 15 732 2.05E-17 91.3 CAR14_MOUSE reviewed Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2) Card14 Bimp2 Mus musculus (Mouse) 999 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001934; GO:0005737; GO:0006915; GO:0033209; GO:0043066; GO:0050700; GO:0051092 0 0 0 PF00619; Q9CR48 CHOYP_LOC100576447.2.2 m.55515 sp DRAM2_MOUSE 37.104 221 132 3 29 247 22 237 2.05E-40 143 DRAM2_MOUSE reviewed DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) Dram2 Tmem77 Mus musculus (Mouse) 267 apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601] GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006914; GO:0006915; GO:0007601; GO:0010506; GO:0016021; GO:0016324; GO:0043231; GO:0045494 0 0 0 PF10277; Q9JI92 CHOYP_RS8.3.14 m.20856 sp SDCB1_RAT 55 280 115 3 4 277 3 277 2.05E-104 316 SDCB1_RAT reviewed Syntenin-1 (Syndecan-binding protein 1) Sdcbp Rattus norvegicus (Rat) 300 actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor internalization [GO:0002091]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346] GO:0001948; GO:0002091; GO:0005137; GO:0005634; GO:0005789; GO:0005829; GO:0005856; GO:0005886; GO:0005895; GO:0005925; GO:0007265; GO:0007268; GO:0007346; GO:0008022; GO:0008284; GO:0010718; GO:0010862; GO:0019838; GO:0030036; GO:0030307; GO:0030335; GO:0030511; GO:0032435; GO:0042043; GO:0042470; GO:0042803; GO:0045121; GO:0045545; GO:0046875; GO:0046982; GO:0050839; GO:0070062; GO:0072562; GO:1903543; GO:1903553 0 0 0 PF00595; Q9NQX5 CHOYP_RL4.2.6 m.4482 sp NPDC1_HUMAN 48.092 131 62 5 125 254 181 306 2.05E-32 124 NPDC1_HUMAN reviewed Neural proliferation differentiation and control protein 1 (NPDC-1) NPDC1 Homo sapiens (Human) 325 0 GO:0016021 0 0 0 PF06809; Q9NS91 CHOYP_AT2G22795.1.1 m.19868 sp RAD18_HUMAN 40.698 86 48 1 3 85 274 359 2.05E-11 69.3 RAD18_HUMAN reviewed E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) RAD18 RNF73 Homo sapiens (Human) 495 "cellular response to DNA damage stimulus [GO:0006974]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; negative regulation of cell death [GO:0060548]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; response to UV [GO:0009411]" GO:0000403; GO:0003684; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005813; GO:0006281; GO:0006301; GO:0006513; GO:0006974; GO:0008270; GO:0009411; GO:0016874; GO:0031593; GO:0031625; GO:0032403; GO:0035861; GO:0042405; GO:0042769; GO:0042802; GO:0043142; GO:0051865; GO:0051984; GO:0060548; GO:0061630; GO:0097505 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02037; Q9R1R2 CHOYP_BRAFLDRAFT_82426.10.20 m.39433 sp TRIM3_MOUSE 37.681 69 38 1 89 152 490 558 2.05E-07 52.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9WU61 CHOYP_LOC101242711.1.1 m.12484 sp CLCC1_RAT 25.549 364 237 12 23 375 20 360 2.05E-25 113 CLCC1_RAT reviewed Chloride channel CLIC-like protein 1 (Mid-1-related chloride channel protein 1) Clcc1 Mclc Rattus norvegicus (Rat) 541 chloride transport [GO:0006821] GO:0005254; GO:0005634; GO:0005737; GO:0005783; GO:0005794; GO:0006821; GO:0034707 0 0 0 PF05934; Q9Z1P6 CHOYP_NDUFA7.2.2 m.57153 sp NDUA7_MOUSE 47.826 69 35 1 47 114 30 98 2.05E-13 64.7 NDUA7_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (CI-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a) Ndufa7 Mus musculus (Mouse) 113 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial translation [GO:0032543]" GO:0003735; GO:0005739; GO:0005747; GO:0005761; GO:0006120; GO:0008137; GO:0032543 0 0 0 PF07347; B0BLT0 CHOYP_LOC592435.1.1 m.51331 sp ZN593_XENTR 55.645 124 53 1 25 146 1 124 2.06E-42 140 ZN593_XENTR reviewed Zinc finger protein 593 znf593 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 0 GO:0003676; GO:0008270 0 0 0 PF12171; B0JZG0 CHOYP_S23A2.3.3 m.66544 sp S23A2_XENTR 33.943 601 362 7 29 622 49 621 2.06E-109 347 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; E9Q735 CHOYP_UBE4A.1.2 m.50333 sp UBE4A_MOUSE 31.673 281 156 8 9 257 9 285 2.06E-34 134 UBE4A_MOUSE reviewed Ubiquitin conjugation factor E4 A (EC 6.3.2.-) Ube4a Ufd2b Mus musculus (Mouse) 1028 protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000209; GO:0005737; GO:0006511; GO:0016874; GO:0034450; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11435423}. 0 0 PF04564;PF10408; O17482 CHOYP_DGRI_GH13197.1.1 m.35578 sp TIM_DROVI 30.858 606 373 15 284 871 516 1093 2.06E-67 249 TIM_DROVI reviewed Protein timeless tim Drosophila virilis (Fruit fly) 1343 rhythmic process [GO:0048511] GO:0005634; GO:0048471; GO:0048511 0 0 0 PF04821; O43916 CHOYP_CHST1.2.3 m.22362 sp CHST1_HUMAN 26.536 358 200 18 42 358 64 399 2.06E-10 65.1 CHST1_HUMAN reviewed Carbohydrate sulfotransferase 1 (EC 2.8.2.21) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1) (GST-1) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) CHST1 Homo sapiens (Human) 411 galactose metabolic process [GO:0006012]; inflammatory response [GO:0006954]; keratan sulfate biosynthetic process [GO:0018146]; keratan sulfate metabolic process [GO:0042339]; polysaccharide metabolic process [GO:0005976]; sulfur compound metabolic process [GO:0006790] GO:0000139; GO:0001517; GO:0005976; GO:0006012; GO:0006790; GO:0006954; GO:0008146; GO:0016021; GO:0018146; GO:0042339; GO:0045130 0 0 0 PF00685; O54692 CHOYP_ZW10.1.1 m.35287 sp ZW10_MOUSE 35.705 787 449 16 2 741 3 779 2.06E-152 465 ZW10_MOUSE reviewed Centromere/kinetochore protein zw10 homolog Zw10 Mus musculus (Mouse) 779 cell division [GO:0051301]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; mitotic cell cycle checkpoint [GO:0007093]; mitotic metaphase plate congression [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint [GO:0007094]; protein complex assembly [GO:0006461]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; regulation of exit from mitosis [GO:0007096] GO:0000070; GO:0000132; GO:0000776; GO:0000777; GO:0000922; GO:0005634; GO:0005737; GO:0005783; GO:0005789; GO:0005828; GO:0006461; GO:0006888; GO:0007030; GO:0007080; GO:0007093; GO:0007094; GO:0007096; GO:0015031; GO:0016020; GO:0034501; GO:0051301; GO:0070939; GO:1990423 0 0 0 PF06248; P00178 CHOYP_CP2B4.1.1 m.45210 sp CP2B4_RABIT 29.12 443 300 9 30 463 29 466 2.06E-55 195 CP2B4_RABIT reviewed Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1) CYP2B4 Oryctolagus cuniculus (Rabbit) 491 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P04634 CHOYP_BRAFLDRAFT_72470.1.1 m.28603 sp LIPG_RAT 50 372 183 3 38 408 26 395 2.06E-137 401 LIPG_RAT reviewed Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) (Lingual lipase) Lipf Rattus norvegicus (Rat) 395 digestion [GO:0007586]; lipid catabolic process [GO:0016042]; malate metabolic process [GO:0006108] GO:0004806; GO:0005576; GO:0005739; GO:0006108; GO:0007586; GO:0016042; GO:0016298; GO:0016615 0 0 0 PF00561; P08962 CHOYP_contig_019371 m.22686 sp CD63_HUMAN 26.699 206 117 8 80 277 55 234 2.06E-08 57.4 CD63_HUMAN reviewed CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) CD63 MLA1 TSPAN30 Homo sapiens (Human) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cellular protein localization [GO:0034613]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigment granule maturation [GO:0048757]; platelet degranulation [GO:0002576]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of rubidium ion transport [GO:2000680]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0002576; GO:0005615; GO:0005765; GO:0005886; GO:0005887; GO:0007160; GO:0009986; GO:0010008; GO:0010633; GO:0015031; GO:0016477; GO:0030855; GO:0031088; GO:0031226; GO:0031902; GO:0031904; GO:0032585; GO:0034613; GO:0035646; GO:0042470; GO:0043234; GO:0045785; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2000680; GO:2001046 0 0 0 PF00335; P16157 CHOYP_AASI_1435.27.35 m.58651 sp ANK1_HUMAN 28.602 472 268 12 223 689 372 779 2.06E-36 154 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_LOC583072.16.25 m.54157 sp ANK1_HUMAN 31.771 576 365 5 30 605 239 786 2.06E-81 283 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P24733 CHOYP_ISCW_ISCW001340.1.1 m.1988 sp MYS_ARGIR 83.495 103 17 0 1 103 1808 1910 2.06E-48 167 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P49888 CHOYP_SULT1E1.3.3 m.41015 sp ST1E1_HUMAN 29.934 304 183 9 8 295 4 293 2.06E-33 127 ST1E1_HUMAN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (EST-1) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 STE Homo sapiens (Human) 294 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; estrogen metabolic process [GO:0008210]; positive regulation of fat cell differentiation [GO:0045600]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] GO:0004062; GO:0004304; GO:0005496; GO:0005829; GO:0008146; GO:0008202; GO:0008210; GO:0045600; GO:0047894; GO:0050294; GO:0050427; GO:0051923 0 0 0 PF00685; P54254 CHOYP_LOC100372922.1.1 m.12888 sp ATX1_MOUSE 67.769 121 39 0 480 600 547 667 2.06E-48 185 ATX1_MOUSE reviewed Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog) Atxn1 Sca1 Mus musculus (Mouse) 791 "adult locomotory behavior [GO:0008344]; excitatory postsynaptic potential [GO:0060079]; lung alveolus development [GO:0048286]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of phosphorylation [GO:0042326]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nuclear export [GO:0051168]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]; visual learning [GO:0008542]" GO:0000122; GO:0003677; GO:0003682; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0008022; GO:0008266; GO:0008344; GO:0008542; GO:0016363; GO:0034046; GO:0042326; GO:0042405; GO:0042802; GO:0043231; GO:0043234; GO:0043569; GO:0043621; GO:0045892; GO:0045944; GO:0048286; GO:0051168; GO:0060079; GO:0060252; GO:0098794 0 0 0 PF12547;PF08517; P57784 CHOYP_RU2A.1.1 m.20848 sp RU2A_MOUSE 69.099 233 70 1 1 231 1 233 2.06E-116 336 RU2A_MOUSE reviewed U2 small nuclear ribonucleoprotein A' (U2 snRNP A') Snrpa1 Mus musculus (Mouse) 255 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0005654; GO:0005681; GO:0005686; GO:0030620; GO:0044822; GO:0071013 0 0 0 0 P61799 CHOYP_LOC592796.1.2 m.43477 sp APTX_DANRE 61.453 179 62 4 56 230 146 321 2.06E-72 226 APTX_DANRE reviewed Aprataxin (EC 3.-.-.-) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) aptx Danio rerio (Zebrafish) (Brachydanio rerio) 324 DNA repair [GO:0006281] GO:0003677; GO:0005654; GO:0005730; GO:0006281; GO:0033699; GO:0046872 0 0 0 PF16278; P62972 CHOYP_LOC100190730.2.2 m.31532 sp UBIQP_XENLA 100 152 0 0 1 152 16 167 2.06E-106 303 UBIQP_XENLA reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Xenopus laevis (African clawed frog) 167 0 GO:0005634; GO:0005737 0 0 0 PF00240; P81491 CHOYP_BRAFLDRAFT_124064.6.6 m.49652 sp SAA5_MESAU 71.569 102 28 1 25 126 2 102 2.06E-46 148 SAA5_MESAU reviewed Serum amyloid A-5 protein 0 Mesocricetus auratus (Golden hamster) 102 acute-phase response [GO:0006953] GO:0006953; GO:0034364 0 0 0 PF00277; P86856 CHOYP_MANL.6.9 m.42625 sp MANL_MYTCA 49.057 159 74 4 45 199 1 156 2.06E-39 146 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q05B18 CHOYP_SHQ1.1.1 m.358 sp SHQ1_XENTR 47.887 426 203 4 21 436 1 417 2.06E-142 425 SHQ1_XENTR reviewed Protein SHQ1 homolog shq1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 604 ribonucleoprotein complex assembly [GO:0022618] GO:0005654; GO:0005829; GO:0022618 0 0 0 PF04925; Q09369 CHOYP_BM1_45740.1.1 m.36320 sp AQP10_CAEEL 28.455 246 163 8 82 319 5 245 2.06E-18 87 AQP10_CAEEL reviewed Putative aquaporin-10 aqp-10 ZK1321.3 Caenorhabditis elegans 280 innate immune response [GO:0045087] GO:0016021; GO:0045087 0 0 0 0 Q25461 CHOYP_ARNP.1.1 m.28290 sp ARNP_MYTED 52.229 157 57 6 77 229 49 191 2.06E-40 140 ARNP_MYTED reviewed APGW-amide-related neuropeptide [Cleaved into: RPGW-amide; KPGW-amide; TPGW-amide] 0 Mytilus edulis (Blue mussel) 196 neuropeptide signaling pathway [GO:0007218] GO:0007218 0 0 0 0 Q26481 CHOYP_BRAFLDRAFT_279789.3.3 m.48128 sp RL5_STYCL 78.462 260 55 1 259 518 8 266 2.06E-150 435 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q27874 CHOYP_PAT3.1.4 m.21678 sp PAT3_CAEEL 36.036 777 443 20 28 773 50 803 2.06E-148 459 PAT3_CAEEL reviewed Integrin beta pat-3 (Paralyzed arrest at two-fold protein 3) pat-3 ZK1058.2 Caenorhabditis elegans 809 cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]; muscle cell development [GO:0055001]; positive regulation of distal tip cell migration [GO:1903356]; positive regulation of locomotion [GO:0040017]; positive regulation of myosin II filament organization [GO:1904901]; positive regulation of ovulation [GO:0060279]; positive regulation of smooth muscle contraction [GO:0045987]; regulation of actin cytoskeleton organization [GO:0032956] GO:0007155; GO:0007229; GO:0008305; GO:0009986; GO:0031430; GO:0032956; GO:0040017; GO:0043005; GO:0043025; GO:0045987; GO:0055001; GO:0055120; GO:0060279; GO:1903356; GO:1904901 0 0 0 PF07974;PF08725;PF07965;PF00362; Q28CH8 CHOYP_LOC100743797.1.1 m.44750 sp YIPF6_XENTR 62.78 223 75 2 17 239 19 233 2.06E-102 299 YIPF6_XENTR reviewed Protein YIPF6 (YIP1 family member 6) yipf6 TGas105o14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 233 0 GO:0016021 0 0 0 PF04893; Q3SZ19 CHOYP_PSMD9.1.1 m.5055 sp PSMD9_BOVIN 48.78 205 102 1 24 225 17 221 2.06E-73 225 PSMD9_BOVIN reviewed 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) PSMD9 Bos taurus (Bovine) 221 proteasome regulatory particle assembly [GO:0070682] GO:0005634; GO:0005737; GO:0008540; GO:0070682 0 0 0 PF13180; Q505J6 CHOYP_DYAK_GE26151.1.1 m.9361 sp GHC2_RAT 51.42 317 122 5 80 376 16 320 2.06E-100 303 GHC2_RAT reviewed Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18) Slc25a18 Rattus norvegicus (Rat) 320 translation [GO:0006412] GO:0003735; GO:0005743; GO:0006412; GO:0015293; GO:0016021 0 0 0 PF00153; Q53G44 CHOYP_LOC101165968.5.7 m.54243 sp IF44L_HUMAN 30.162 431 275 6 25 450 26 435 2.06E-48 175 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q54KA7 CHOYP_TVAG_291510.4.9 m.21391 sp SECG_DICDI 36.972 284 145 1 5 254 195 478 2.06E-43 160 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q55FM5 CHOYP_DMOJ_GI10598.1.1 m.43592 sp MTPN_DICDI 52.294 109 40 1 12 108 12 120 2.06E-32 112 MTPN_DICDI reviewed Myotrophin homolog mtpn DDB_G0268038 Dictyostelium discoideum (Slime mold) 120 0 GO:0005634; GO:0005737 0 0 0 0 Q56K03 CHOYP_LOC100533291.6.7 m.38538 sp RL27A_BOVIN 76.19 147 34 1 17 162 2 148 2.06E-77 229 RL27A_BOVIN reviewed 60S ribosomal protein L27a RPL27A Bos taurus (Bovine) 148 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00828; Q57664 CHOYP_NEMVEDRAFT_V1G86755.1.1 m.62215 sp GALE_METJA 34.722 144 85 5 11 149 2 141 2.06E-15 74.7 GALE_METJA reviewed Putative UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase) MJ0211 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 305 galactose metabolic process [GO:0006012] GO:0003978; GO:0006012; GO:0050662 PATHWAY: Carbohydrate metabolism; galactose metabolism. 0 0 PF01370; Q5F478 CHOYP_AASI_1435.29.35 m.61402 sp ANR44_CHICK 33.101 716 447 5 35 718 8 723 2.06E-108 355 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5RBD3 CHOYP_SHEP.1.1 m.27990 sp RBMS3_PONAB 52.234 291 101 9 47 321 54 322 2.06E-86 271 RBMS3_PONAB reviewed "RNA-binding motif, single-stranded-interacting protein 3" RBMS3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 436 0 GO:0000166; GO:0003723; GO:0005737 0 0 0 PF00076; Q61830 CHOYP_LOC576927.3.4 m.3410 sp MRC1_MOUSE 23.993 571 356 22 6 532 485 1021 2.06E-26 119 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q64259 CHOYP_BRAFLDRAFT_280480.1.1 m.55075 sp VHL_RAT 33.582 134 84 3 12 145 28 156 2.06E-14 70.5 VHL_RAT reviewed Von Hippel-Lindau disease tumor suppressor (pVHL) Vhl Rattus norvegicus (Rat) 185 "angiogenesis [GO:0001525]; blood vessel endothelial cell migration [GO:0043534]; ciliary body morphogenesis [GO:0061073]; extracellular matrix organization [GO:0030198]; eye pigmentation [GO:0048069]; homeostasis of number of retina cells [GO:0048877]; iris morphogenesis [GO:0061072]; melanin metabolic process [GO:0006582]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902072]; negative regulation of thymocyte apoptotic process [GO:0070244]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron differentiation [GO:0030182]; NLS-bearing protein import into nucleus [GO:0006607]; pancreatic A cell differentiation [GO:0003310]; positive regulation of epithelial cell proliferation [GO:0050679]; proteasomal protein catabolic process [GO:0010498]; protein heterooligomerization [GO:0051291]; protein ubiquitination [GO:0016567]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of catecholamine metabolic process [GO:0042069]; regulation of cellular protein localization [GO:1903827]; regulation of transcription, DNA-templated [GO:0006355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; type B pancreatic cell differentiation [GO:0003309]" GO:0000122; GO:0001525; GO:0001666; GO:0003309; GO:0003310; GO:0005634; GO:0005654; GO:0005667; GO:0005730; GO:0005739; GO:0005829; GO:0005929; GO:0006355; GO:0006582; GO:0006607; GO:0008134; GO:0010498; GO:0016020; GO:0016567; GO:0030182; GO:0030198; GO:0030891; GO:0031462; GO:0032403; GO:0042069; GO:0043534; GO:0045471; GO:0045602; GO:0048069; GO:0048877; GO:0050679; GO:0051291; GO:0061072; GO:0061073; GO:0061630; GO:0070244; GO:1902072; GO:1903827; GO:2001233 PATHWAY: Protein modification; protein ubiquitination. 0 cd05468; PF01847;PF17211; Q6B9X6 CHOYP_LOC100213222.2.2 m.63358 sp VWKA_DICDI 25.592 211 128 5 27 230 407 595 2.06E-15 80.1 VWKA_DICDI reviewed Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) 625 contractile vacuole discharge [GO:0070177]; contractile vacuole organization [GO:0033298]; hypotonic response [GO:0006971]; mitotic cytokinesis [GO:0000281]; myosin II filament organization [GO:0031038]; peptidyl-serine modification [GO:0018209]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; regulation of sorocarp development [GO:0031156]; sorocarp morphogenesis [GO:0031288] GO:0000281; GO:0000331; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006971; GO:0018107; GO:0018209; GO:0031038; GO:0031156; GO:0031164; GO:0031288; GO:0033298; GO:0048471; GO:0070177 0 0 0 PF02816; Q6GPB8 CHOYP_LOC577338.1.1 m.9819 sp DBR1A_XENLA 61.68 381 143 3 1 379 1 380 2.06E-178 520 DBR1A_XENLA reviewed Lariat debranching enzyme A (EC 3.1.-.-) dbr1-a Xenopus laevis (African clawed frog) 534 "mRNA processing [GO:0006397]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0005634; GO:0006397; GO:0008419 0 0 0 PF05011;PF00149; Q6ZQ12 CHOYP_LOC583607.1.4 m.4600 sp NINL_MOUSE 30.919 566 310 17 169 718 99 599 2.06E-55 216 NINL_MOUSE reviewed Ninein-like protein Ninl Kiaa0980 Nlp Mus musculus (Mouse) 1394 microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005509; GO:0005737; GO:0005815; GO:0005856; GO:0005874 0 0 0 PF13499; Q7RTR2 CHOYP_NLRC3.1.1 m.57383 sp NLRC3_HUMAN 23.94 401 262 11 725 1095 676 1063 2.06E-10 68.9 NLRC3_HUMAN reviewed Protein NLRC3 (CARD15-like protein) (Caterpiller protein 16.2) (CLR16.2) (Nucleotide-binding oligomerization domain protein 3) NLRC3 NOD3 Homo sapiens (Human) 1065 I-kappaB kinase/NF-kappaB signaling [GO:0007249]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of tumor necrosis factor production [GO:0032720]; T cell activation [GO:0042110] GO:0005524; GO:0005737; GO:0007249; GO:0032088; GO:0032715; GO:0032720; GO:0042110; GO:0043124 0 0 0 PF13516; Q811F1 CHOYP_ZN521.2.3 m.13584 sp ZBT41_MOUSE 24.074 270 168 9 487 738 347 597 2.06E-07 59.3 ZBT41_MOUSE reviewed Zinc finger and BTB domain-containing protein 41 Zbtb41 Mus musculus (Mouse) 908 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF13912; Q8AVU4 CHOYP_HES1.1.3 m.10538 sp HES1B_XENLA 39.777 269 112 9 32 286 35 267 2.06E-51 172 HES1B_XENLA reviewed Transcription factor HES-1-B (Hairy and enhancer of split 1-B) hes1-b Xenopus laevis (African clawed frog) 267 "multicellular organism development [GO:0007275]; negative regulation of muscle organ development [GO:0048635]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005634; GO:0006351; GO:0007219; GO:0007275; GO:0043425; GO:0045892; GO:0046982; GO:0048635 0 0 0 PF07527;PF00010; Q8C419 CHOYP_SMP_149390.1.1 m.8819 sp GP158_MOUSE 35.714 112 55 5 278 385 263 361 2.06E-11 72 GP158_MOUSE reviewed Probable G-protein coupled receptor 158 Gpr158 Kiaa1136 Mus musculus (Mouse) 1200 protein localization to plasma membrane [GO:0072659]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0004930; GO:0005886; GO:0008277; GO:0016020; GO:0016021; GO:0072659 0 0 0 PF00003; Q8IT98 CHOYP_RS18.6.11 m.35640 sp RS18_ARGIR 86.239 109 15 0 8 116 1 109 2.06E-69 208 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8NDA2 CHOYP_PHUM_PHUM311500.1.1 m.43261 sp HMCN2_HUMAN 24.879 414 258 19 57 431 2671 3070 2.06E-14 80.9 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8R035 CHOYP_CARNS1.6.6 m.64239 sp ICT1_MOUSE 39.888 178 96 3 32 205 36 206 2.06E-34 124 ICT1_MOUSE reviewed "Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Immature colon carcinoma transcript 1 protein homolog)" Ict1 Mrpl58 Mus musculus (Mouse) 206 mitochondrial translational termination [GO:0070126]; rescue of stalled ribosome [GO:0072344] GO:0004045; GO:0005739; GO:0005762; GO:0016150; GO:0043022; GO:0070126; GO:0072344 0 0 0 PF00472; Q8WXF0 CHOYP_ISCW_ISCW023180.1.2 m.31255 sp SRS12_HUMAN 60.952 105 37 1 1 105 1 101 2.06E-43 150 SRS12_HUMAN reviewed "Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)" SRSF12 SFRS13B SFRS19 SRRP35 Homo sapiens (Human) 261 "mRNA 5'-splice site recognition [GO:0000395]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000166; GO:0000244; GO:0000381; GO:0000395; GO:0003723; GO:0005654; GO:0044822; GO:0048025; GO:0050733; GO:0051082 0 0 0 PF00076; Q90972 CHOYP_RNF13.1.1 m.19259 sp RNF13_CHICK 39.228 311 173 9 17 322 13 312 2.06E-67 223 RNF13_CHICK reviewed E3 ubiquitin-protein ligase RNF13 (EC 6.3.2.-) (C-RZF) (RING finger protein 13) RNF13 RZF Gallus gallus (Chicken) 381 protein autoubiquitination [GO:0051865] GO:0004842; GO:0005634; GO:0005765; GO:0008270; GO:0016021; GO:0016874; GO:0031902; GO:0051865; GO:0061630 0 0 0 PF02225;PF13639; Q96MM6 CHOYP_NEMVEDRAFT_V1G212312.3.5 m.48092 sp HS12B_HUMAN 30.562 409 221 11 8 354 124 531 2.06E-46 171 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96PZ0 CHOYP_AAEL_AAEL003071.1.1 m.14686 sp PUS7_HUMAN 42.453 106 61 0 1 106 551 656 2.06E-23 97.4 PUS7_HUMAN reviewed Pseudouridylate synthase 7 homolog (EC 5.4.99.-) PUS7 KIAA1897 Homo sapiens (Human) 661 pseudouridine synthesis [GO:0001522]; tRNA processing [GO:0008033] GO:0001522; GO:0005634; GO:0008033; GO:0009982; GO:0019899; GO:0044822 0 0 0 PF01142; Q96WV6 CHOYP_contig_014919 m.17208 sp YHU2_SCHPO 32.645 484 279 9 2 467 1674 2128 2.06E-09 63.9 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q99M71 CHOYP_EPDR2.1.1 m.33988 sp EPDR1_MOUSE 25.962 208 127 9 6 196 24 221 2.06E-07 52.8 EPDR1_MOUSE reviewed Mammalian ependymin-related protein 1 (MERP-1) Epdr1 Epdr2 Merp1 Merp2 Mus musculus (Mouse) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; Q9BZE0 CHOYP_LOC101159893.1.1 m.31351 sp GLIS2_HUMAN 71.519 158 44 1 216 373 170 326 2.06E-78 258 GLIS2_HUMAN reviewed Zinc finger protein GLIS2 (GLI-similar 2) (Neuronal Krueppel-like protein) GLIS2 NKL Homo sapiens (Human) 524 "cell differentiation [GO:0030154]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000122; GO:0001077; GO:0005634; GO:0005737; GO:0007399; GO:0016607; GO:0030154; GO:0043433; GO:0044212; GO:0045879; GO:0045892; GO:0045893; GO:0045944; GO:0046872 0 0 0 0 Q9XZ71 CHOYP_ISCW_ISCW022189.1.1 m.8227 sp TNNT_PERAM 39.3 257 136 6 33 285 42 282 2.06E-30 121 TNNT_PERAM reviewed Troponin T (TnT) TNT Periplaneta americana (American cockroach) (Blatta americana) 384 regulation of muscle contraction [GO:0006937] GO:0005861; GO:0006937 0 0 0 PF00992; Q9Y5Q5 CHOYP_PHUM_PHUM534870.1.1 m.23450 sp CORIN_HUMAN 29.289 478 304 15 261 727 581 1035 2.06E-48 187 CORIN_HUMAN reviewed "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) 1042 female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] GO:0003050; GO:0004252; GO:0005576; GO:0005886; GO:0005887; GO:0007565; GO:0008217; GO:0009986; GO:0016021; GO:0016486; GO:0035813; GO:1903779 0 0 cd00190; PF01392;PF00057;PF15494;PF00089; A4IF63 CHOYP_BRAFLDRAFT_87311.1.2 m.20504 sp TRIM2_BOVIN 36.364 88 52 3 35 121 623 707 2.07E-09 57.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6H6E2 CHOYP_LOC100698649.7.8 m.48104 sp MMRN2_MOUSE 30.075 133 83 3 100 232 818 940 2.07E-09 60.8 MMRN2_MOUSE reviewed Multimerin-2 Mmrn2 Mus musculus (Mouse) 943 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; B2RXR6 CHOYP_LOC583072.19.25 m.54897 sp ANR44_MOUSE 22.74 1073 644 27 527 1548 11 949 2.07E-40 167 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; D3ZAT9 CHOYP_LOC100377010.4.16 m.18140 sp FAXC_RAT 35.537 242 139 5 43 272 98 334 2.07E-48 169 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; E1BD59 CHOYP_BRAFLDRAFT_85511.12.23 m.33923 sp TRI56_BOVIN 24.382 283 168 7 15 288 18 263 2.07E-16 87 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; E1BD59 CHOYP_TRI56.1.4 m.4907 sp TRI56_BOVIN 35.537 242 138 6 3 232 9 244 2.07E-40 150 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O35474 CHOYP_BRAFLDRAFT_88018.1.1 m.50147 sp EDIL3_MOUSE 26.866 201 121 8 178 358 121 315 2.07E-11 68.6 EDIL3_MOUSE reviewed EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) Edil3 Del1 Mus musculus (Mouse) 480 cell adhesion [GO:0007155]; multicellular organism development [GO:0007275]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0005509; GO:0007155; GO:0007275; GO:0010811; GO:0070062; GO:1903561 0 0 0 PF00008;PF00754;PF12661; O43829 CHOYP_ZN641.1.1 m.868 sp ZBT14_HUMAN 29.545 220 139 7 40 247 164 379 2.07E-13 72.8 ZBT14_HUMAN reviewed Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) ZBTB14 ZFP161 ZNF478 Homo sapiens (Human) 449 "cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003170; GO:0003279; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0043565; GO:0044212; GO:0045892; GO:0046872; GO:0060976 0 0 0 PF00651;PF00096; O95817 CHOYP_NAEGRDRAFT_63560.2.2 m.46900 sp BAG3_HUMAN 50 42 21 0 7 48 21 62 2.07E-06 54.3 BAG3_HUMAN reviewed BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) 575 brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cellular response to heat [GO:1900034]; spinal cord development [GO:0021510] GO:0000774; GO:0005737; GO:0005829; GO:0005886; GO:0005913; GO:0006457; GO:0007420; GO:0008625; GO:0010664; GO:0021510; GO:0030018; GO:0043005; GO:0043066; GO:0050821; GO:0071260; GO:0097192; GO:0098641; GO:1900034 0 0 0 PF02179;PF00397; P02599 CHOYP_OT01G03840.1.1 m.27282 sp CALM_DICDI 38.095 147 89 2 10 155 1 146 2.07E-27 103 CALM_DICDI reviewed Calmodulin (CaM) calA camA DDB_G0279407 Dictyostelium discoideum (Slime mold) 152 establishment of protein localization to vacuole [GO:0072666]; mitotic cytokinesis [GO:0000281]; negative regulation of asexual reproduction [GO:1903665]; negative regulation of proteolysis [GO:0045861]; positive regulation of ATPase activity [GO:0032781]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of positive chemotaxis to cAMP [GO:0061122]; regulation of kinase activity [GO:0043549] GO:0000281; GO:0000331; GO:0005509; GO:0005615; GO:0005622; GO:0005634; GO:0005737; GO:0019900; GO:0019901; GO:0031012; GO:0031013; GO:0032781; GO:0043549; GO:0045861; GO:0050839; GO:0051343; GO:0061122; GO:0072666; GO:1903665 0 0 0 PF13499; P07290 CHOYP_ZC3HF.1.1 m.39870 sp MLE_MIZYE 79.798 99 19 1 1 99 58 155 2.07E-52 164 MLE_MIZYE reviewed "Myosin, essential light chain, adductor muscle (Sulfhydryl light chain) (SHLC)" 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 156 0 GO:0005509; GO:0016459 0 0 0 PF13499; P16157 CHOYP_TVAG_020440.3.21 m.3901 sp ANK1_HUMAN 38.168 262 162 0 1 262 242 503 2.07E-45 166 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P23468 CHOYP_LOC100635116.4.5 m.44374 sp PTPRD_HUMAN 30.172 580 367 11 521 1072 1337 1906 2.07E-72 268 PTPRD_HUMAN reviewed Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) PTPRD Homo sapiens (Human) 1912 chemical synaptic transmission [GO:0007268]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron differentiation [GO:0030182]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of dendrite morphogenesis [GO:0050775]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005102; GO:0005886; GO:0005887; GO:0006470; GO:0006796; GO:0007157; GO:0007185; GO:0007268; GO:0030182; GO:0050775; GO:0050839; GO:0070062; GO:0097105 0 0 0 PF00041;PF07679;PF00102; P41386 CHOYP_LOC373275.3.7 m.38058 sp TBB_HALDI 98.718 78 1 0 96 173 69 146 2.07E-48 162 TBB_HALDI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Haliotis discus (Abalone) (Nordotis discus) 341 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P58743 CHOYP_S26A5.1.2 m.6712 sp S26A5_HUMAN 36.863 746 396 13 56 789 51 733 2.07E-157 480 S26A5_HUMAN reviewed Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Homo sapiens (Human) 744 bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; fructose transport [GO:0015755]; negative regulation of ion transmembrane transport [GO:0034766]; positive regulation of cell motility [GO:2000147]; positive regulation of cell size [GO:0045793]; protein tetramerization [GO:0051262]; regulation of cell shape [GO:0008360]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; response to drug [GO:0042493]; response to ischemia [GO:0002931]; response to potassium ion [GO:0035864]; response to salicylic acid [GO:0009751]; response to salt [GO:1902074]; response to thyroid hormone [GO:0097066]; sensory perception of sound [GO:0007605] GO:0002931; GO:0005254; GO:0005737; GO:0005887; GO:0007605; GO:0008271; GO:0008360; GO:0009751; GO:0010996; GO:0015106; GO:0015116; GO:0015301; GO:0015701; GO:0015755; GO:0016323; GO:0016328; GO:0019531; GO:0034766; GO:0035864; GO:0042391; GO:0042493; GO:0045793; GO:0051262; GO:0051453; GO:0090102; GO:0097066; GO:1902074; GO:1902476; GO:2000147 0 0 0 PF01740;PF00916; P62890 CHOYP_LOC659206.6.6 m.43545 sp RL30_RAT 82.301 113 20 0 1 113 1 113 2.07E-66 198 RL30_RAT reviewed 60S ribosomal protein L30 Rpl30 Rattus norvegicus (Rat) 115 liver regeneration [GO:0097421]; positive regulation of selenocysteine incorporation [GO:1904571]; selenocysteine metabolic process [GO:0016259]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005829; GO:0005840; GO:0005925; GO:0006412; GO:0016020; GO:0016259; GO:0022625; GO:0035368; GO:0070062; GO:0097421; GO:1904571 0 0 0 PF01248; P78560 CHOYP_CRADD.2.2 m.35768 sp CRADD_HUMAN 24.211 190 140 3 9 196 1 188 2.07E-07 52.8 CRADD_HUMAN reviewed Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) CRADD RAIDD Homo sapiens (Human) 199 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic signaling pathway [GO:2001235]; regulation of apoptotic process [GO:0042981]" GO:0002020; GO:0005634; GO:0005737; GO:0005829; GO:0006919; GO:0006977; GO:0008625; GO:0030674; GO:0042981; GO:0070513; GO:0071260; GO:2001235 0 0 0 PF00619;PF00531; P97411 CHOYP_LOC100373653.3.3 m.56289 sp ICA69_MOUSE 45 540 201 8 21 554 20 469 2.07E-141 420 ICA69_MOUSE reviewed Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) Ica1 Icap69 Mus musculus (Mouse) 478 neurotransmitter transport [GO:0006836]; regulation of insulin secretion [GO:0050796]; regulation of neurotransmitter secretion [GO:0046928]; regulation of protein homodimerization activity [GO:0043496] GO:0000139; GO:0005737; GO:0005794; GO:0005795; GO:0005829; GO:0006836; GO:0030054; GO:0030425; GO:0030667; GO:0030672; GO:0043496; GO:0046928; GO:0048471; GO:0050796 0 0 0 PF06456;PF04629; Q10131 CHOYP_LOC662072.1.1 m.51458 sp CEX1_CAEEL 31.383 188 115 4 9 190 25 204 2.07E-19 84.7 CEX1_CAEEL reviewed Calexcitin-1 cex-1 F56D1.6 Caenorhabditis elegans 204 0 GO:0005509 0 0 0 0 Q13263 CHOYP_LOC100370588.11.19 m.32781 sp TIF1B_HUMAN 26.415 212 139 8 2 200 135 342 2.07E-09 61.2 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q16658 CHOYP_LOC661226.1.1 m.62936 sp FSCN1_HUMAN 42.596 493 268 9 14 499 9 493 2.07E-135 403 FSCN1_HUMAN reviewed Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) FSCN1 FAN1 HSN SNL Homo sapiens (Human) 493 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; anatomical structure morphogenesis [GO:0009653]; cell-cell junction assembly [GO:0007043]; cell migration [GO:0016477]; cell motility [GO:0048870]; cell proliferation [GO:0008283]; establishment of apical/basal cell polarity [GO:0035089]; microspike assembly [GO:0030035]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of podosome assembly [GO:0071803]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microvillus assembly [GO:0032534] GO:0001725; GO:0001726; GO:0002102; GO:0003779; GO:0005737; GO:0005829; GO:0005856; GO:0005902; GO:0005911; GO:0005913; GO:0007043; GO:0008144; GO:0008283; GO:0009653; GO:0010592; GO:0015629; GO:0016477; GO:0030027; GO:0030035; GO:0030036; GO:0030175; GO:0030426; GO:0031253; GO:0031941; GO:0032534; GO:0032956; GO:0035089; GO:0043209; GO:0044393; GO:0044822; GO:0048870; GO:0051015; GO:0051017; GO:0051491; GO:0070062; GO:0071437; GO:0071803; GO:0090091; GO:0098641 0 0 0 PF06268; Q1LYM3 CHOYP_ISCW_ISCW003557.1.1 m.63936 sp SPIR1_DANRE 34.759 187 114 2 608 794 550 728 2.07E-24 113 SPIR1_DANRE reviewed Protein spire homolog 1 spire1 si:ch211-215i13.7 zgc:153436 Danio rerio (Zebrafish) (Brachydanio rerio) 761 actin nucleation [GO:0045010]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005829; GO:0005856; GO:0005886; GO:0015031; GO:0016192; GO:0030659; GO:0045010; GO:0048471 0 0 0 PF16474; Q29448 CHOYP_LOC100710578.1.1 m.62426 sp HMGCL_BOVIN 67.961 309 99 0 21 329 13 321 2.07E-153 436 HMGCL_BOVIN reviewed "Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)" HMGCL Bos taurus (Bovine) 325 ketone body biosynthetic process [GO:0046951]; mitochondrion organization [GO:0007005]; protein tetramerization [GO:0051262] GO:0000287; GO:0004419; GO:0005743; GO:0005759; GO:0005777; GO:0007005; GO:0030145; GO:0046872; GO:0046951; GO:0051262 PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1. 0 0 PF00682; Q2TGI8 CHOYP_LOC100881080.1.1 m.16601 sp ZDH22_RAT 28.926 242 138 7 68 296 29 249 2.07E-26 108 ZDH22_RAT reviewed Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) Zdhhc22 Rattus norvegicus (Rat) 263 protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345] GO:0005783; GO:0005794; GO:0008270; GO:0016021; GO:0018345; GO:0019706; GO:0072659 0 0 0 PF01529; Q3USL1 CHOYP_SMP_127750.2.2 m.48890 sp KLDC9_MOUSE 31.596 307 189 9 27 314 29 333 2.07E-33 129 KLDC9_MOUSE reviewed Kelch domain-containing protein 9 Klhdc9 Mus musculus (Mouse) 350 0 0 0 0 0 0 Q4ZYK5 CHOYP_CHRO_0413.1.2 m.16022 sp SELU_PSEU2 31.212 330 191 13 52 351 18 341 2.07E-33 131 SELU_PSEU2 reviewed tRNA 2-selenouridine synthase (EC 2.9.1.-) (Selenophosphate-dependent tRNA 2-selenouridine synthase) selU Psyr_0697 Pseudomonas syringae pv. syringae (strain B728a) 366 tRNA seleno-modification [GO:0070329] GO:0043828; GO:0070329 0 0 0 0 Q5EA40 CHOYP_BCAT1.1.1 m.54127 sp BCAT2_BOVIN 56.098 369 160 2 24 391 26 393 2.07E-155 446 BCAT2_BOVIN reviewed "Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT(m)) (EC 2.6.1.42)" BCAT2 Bos taurus (Bovine) 393 aspartate biosynthetic process [GO:0006532]; branched-chain amino acid biosynthetic process [GO:0009082]; leucine biosynthetic process [GO:0009098]; valine biosynthetic process [GO:0009099] GO:0004084; GO:0005739; GO:0006532; GO:0009082; GO:0009098; GO:0009099; GO:0030170; GO:0052654; GO:0052655; GO:0052656 0 0 0 PF01063; Q5VVH5 CHOYP_BRAFLDRAFT_122970.1.1 m.52022 sp IKBP1_HUMAN 39.453 256 143 3 1 244 1 256 2.07E-58 189 IKBP1_HUMAN reviewed Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1) IRAK1BP1 Homo sapiens (Human) 260 "I-kappaB kinase/NF-kappaB signaling [GO:0007249]; immune response [GO:0006955]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005622; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006955; GO:0007249 0 0 0 PF04402; Q5ZKP7 CHOYP_LOC100169180.1.1 m.21961 sp S2536_CHICK 54.268 328 122 5 3 319 2 312 2.07E-114 336 S2536_CHICK reviewed Solute carrier family 25 member 36 SLC25A36 RCJMB04_9m7 Gallus gallus (Chicken) 313 mitochondrial genome maintenance [GO:0000002]; regulation of mitochondrial membrane potential [GO:0051881]; translation [GO:0006412] GO:0000002; GO:0003735; GO:0005743; GO:0006412; GO:0015218; GO:0016021; GO:0051881 0 0 0 PF00153; Q61503 CHOYP_TRIADDRAFT_57018.2.2 m.11112 sp 5NTD_MOUSE 45.422 557 286 7 52 601 28 573 2.07E-162 479 5NTD_MOUSE reviewed 5'-nucleotidase (5'-NT) (EC 3.1.3.5) (Ecto-5'-nucleotidase) (CD antigen CD73) Nt5e Nt5 Nte Mus musculus (Mouse) 576 adenosine biosynthetic process [GO:0046086]; AMP catabolic process [GO:0006196]; brain development [GO:0007420]; leukocyte cell-cell adhesion [GO:0007159]; negative regulation of inflammatory response [GO:0050728]; positive regulation of lipid biosynthetic process [GO:0046889]; purine nucleotide biosynthetic process [GO:0006164]; response to aluminum ion [GO:0010044] GO:0000166; GO:0005737; GO:0005886; GO:0006164; GO:0006196; GO:0007159; GO:0007420; GO:0008198; GO:0008253; GO:0009986; GO:0010044; GO:0016020; GO:0031225; GO:0046086; GO:0046889; GO:0050728; GO:0070062; GO:0097060 0 0 0 PF02872;PF00149; Q62656 CHOYP_PTPRZ.7.9 m.42362 sp PTPRZ_RAT 31.57 567 340 13 489 1016 1700 2257 2.07E-69 258 PTPRZ_RAT reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (3F8 chondroitin sulfate proteoglycan) (3H1 keratan sulfate proteoglycan) (Phosphacan) Ptprz1 Ptprz Ptpz Rattus norvegicus (Rat) 2316 axonal fasciculation [GO:0007413]; brain development [GO:0007420]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; neuron development [GO:0048666]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; protein dephosphorylation [GO:0006470]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0004725; GO:0005615; GO:0005737; GO:0006470; GO:0007413; GO:0007420; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0010976; GO:0016020; GO:0016021; GO:0016791; GO:0017134; GO:0021766; GO:0030027; GO:0030175; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048666; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; Q6AYR9 CHOYP_LOC751836.5.6 m.43257 sp TSN1_RAT 27.559 254 151 8 11 261 8 231 2.07E-14 74.3 TSN1_RAT reviewed Tetraspanin-1 (Tspan-1) Tspan1 Rattus norvegicus (Rat) 241 cell migration [GO:0016477]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of endocytosis [GO:0045807]; protein stabilization [GO:0050821] GO:0005765; GO:0005887; GO:0007166; GO:0008283; GO:0016477; GO:0045807; GO:0048471; GO:0050821; GO:0070062 0 0 0 PF00335; Q6DGU5 CHOYP_S2546.1.1 m.49107 sp S2546_DANRE 41.902 389 200 5 3 379 27 401 2.07E-102 313 S2546_DANRE reviewed Solute carrier family 25 member 46 slc25a46 si:ch211-220b11.2 zgc:92767 Danio rerio (Zebrafish) (Brachydanio rerio) 405 axon development [GO:0061564]; mitochondrial fission [GO:0000266]; mitochondrial membrane fission [GO:0090149]; neuron projection development [GO:0031175]; transport [GO:0006810] GO:0000266; GO:0005741; GO:0006810; GO:0016021; GO:0031175; GO:0043005; GO:0061564; GO:0090149 0 0 0 PF00153; Q6PFY8 CHOYP_LOC100375954.2.6 m.32502 sp TRI45_MOUSE 29.756 205 120 7 3 194 126 319 2.07E-11 65.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6VMQ6 CHOYP_LOC100881659.1.1 m.14698 sp MCAF1_HUMAN 35.144 313 157 12 813 1093 966 1264 2.07E-29 130 MCAF1_HUMAN reviewed Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621) ATF7IP MCAF MCAF1 Homo sapiens (Human) 1270 "DNA methylation [GO:0006306]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045898]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0000122; GO:0003714; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006306; GO:0006351; GO:0016032; GO:0016887; GO:0045892; GO:0045893; GO:0045898 0 0 0 PF16788;PF16794; Q6XIM8 CHOYP_RS15A.6.11 m.23616 sp RS15A_DROYA 86.842 114 15 0 1 114 4 117 2.07E-72 214 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q6ZRF8 CHOYP_LOC100373444.76.79 m.61783 sp RN207_HUMAN 27.751 209 127 10 22 223 103 294 2.07E-11 70.5 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q80U95 CHOYP_LOC100374388.1.2 m.1459 sp UBE3C_MOUSE 67.066 334 107 3 1 333 752 1083 2.07E-160 479 UBE3C_MOUSE reviewed Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) Ube3c Kiaa0010 Kiaa10 Mus musculus (Mouse) 1083 protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0004842; GO:0005634; GO:0005737; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q8BZH4 CHOYP_LOC100366436.1.1 m.1441 sp POGZ_MOUSE 32.54 378 216 10 277 626 466 832 2.07E-53 209 POGZ_MOUSE reviewed Pogo transposable element with ZNF domain Pogz Kiaa0461 Mus musculus (Mouse) 1409 cell division [GO:0051301]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064] GO:0000790; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0007064; GO:0046872; GO:0051301; GO:0051382 0 0 0 PF03184;PF03221; Q8I7P9 CHOYP_CRE_30767.1.2 m.51495 sp POL5_DROME 31.395 172 113 3 41 210 162 330 2.07E-12 70.5 POL5_DROME reviewed Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1003 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003676; GO:0003964; GO:0004519; GO:0005634; GO:0006313; GO:0008233; GO:0015074 0 0 0 PF00665;PF00078; Q8WUY3 CHOYP_LOC100401760.1.1 m.2386 sp PRUN2_HUMAN 46.667 150 51 5 433 553 2797 2946 2.07E-32 136 PRUN2_HUMAN reviewed Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) PRUNE2 BMCC1 BNIPXL C9orf65 KIAA0367 Homo sapiens (Human) 3088 apoptotic process [GO:0006915] GO:0005737; GO:0006915; GO:0016462; GO:0046872 0 0 0 PF12496;PF13716;PF02833; Q92193 CHOYP_CPIPJ_CPIJ005785.1.1 m.13044 sp ACT_CRAVI 74.194 124 3 1 1 124 107 201 2.07E-56 179 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q964E1 CHOYP_ACTC.1.6 m.14812 sp ACTC_BIOOB 51.289 349 162 4 1 345 1 345 2.07E-122 360 ACTC_BIOOB reviewed "Actin, cytoplasmic" 0 Biomphalaria obstructa (Bloodfluke planorb) (Freshwater snail) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q99NH0 CHOYP_LOC583072.4.25 m.20256 sp ANR17_MOUSE 30.365 438 289 12 32 455 218 653 2.07E-44 171 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BYK8 CHOYP_LOC583716.3.4 m.36810 sp HELZ2_HUMAN 27.479 1674 978 55 656 2238 1097 2625 2.07E-152 532 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9EQZ7 CHOYP_LOC659945.1.1 m.40360 sp RIMS2_MOUSE 33.908 174 111 3 38 208 1329 1501 2.07E-20 92.4 RIMS2_MOUSE reviewed Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2) Rims2 Rab3ip2 Rim2 Mus musculus (Mouse) 1530 calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cAMP-mediated signaling [GO:0019933]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; spontaneous neurotransmitter secretion [GO:0061669] GO:0005622; GO:0006886; GO:0007269; GO:0010628; GO:0017156; GO:0017157; GO:0019933; GO:0030054; GO:0030073; GO:0042391; GO:0043005; GO:0044325; GO:0046872; GO:0048786; GO:0048791; GO:0061669; GO:0070062; GO:0097151; GO:1903861; GO:2000463 0 0 0 PF00168;PF02318; Q9H2Y7 CHOYP_ZN106.1.1 m.7317 sp ZN106_HUMAN 32.394 355 228 6 1631 1979 1527 1875 2.07E-52 208 ZN106_HUMAN reviewed Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) ZNF106 SH3BP3 ZFP106 ZNF474 Homo sapiens (Human) 1883 insulin receptor signaling pathway [GO:0008286] GO:0005730; GO:0005829; GO:0008286; GO:0016020; GO:0017124; GO:0044822; GO:0046872 0 0 0 PF00400; Q9H8L6 CHOYP_CBLN1.1.2 m.41687 sp MMRN2_HUMAN 31.148 122 80 3 75 196 813 930 2.07E-08 57.4 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; Q9NUV9 CHOYP_LOC792450.1.1 m.59274 sp GIMA4_HUMAN 42.029 276 137 5 233 491 27 296 2.07E-58 202 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9PTG8 CHOYP_TACC3.2.3 m.13037 sp TACC3_XENLA 31.22 410 219 10 753 1156 577 929 2.07E-37 156 TACC3_XENLA reviewed Transforming acidic coiled-coil-containing protein 3 (Cytoplasmic polyadenylation element-binding protein-associated factor Maskin) (CPEB-associated factor Maskin) tacc3 maskin Xenopus laevis (African clawed frog) 931 negative regulation of translation [GO:0017148] GO:0005737; GO:0017148; GO:0031369; GO:0043234 0 0 0 PF05010; Q9TRY0 CHOYP_LOC100709316.1.1 m.17221 sp FKBP4_BOVIN 52.97 404 190 0 7 410 21 424 2.07E-147 431 FKBP4_BOVIN reviewed "Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (FK506-binding protein 4) (FKBP-4) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]" FKBP4 Bos taurus (Bovine) 459 chaperone-mediated protein folding [GO:0061077]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977] GO:0003755; GO:0005528; GO:0005634; GO:0005739; GO:0005789; GO:0005829; GO:0005874; GO:0010977; GO:0031111; GO:0044295; GO:0061077 0 0 0 PF00254;PF00515;PF07719; Q9UBS3 CHOYP_LOC100706374.1.1 m.51988 sp DNJB9_HUMAN 37.024 289 103 12 1 278 1 221 2.07E-37 134 DNJB9_HUMAN reviewed DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) DNAJB9 MDG1 UNQ743/PRO1471 Homo sapiens (Human) 223 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; IRE1-mediated unfolded protein response [GO:0036498] GO:0005730; GO:0005737; GO:0005783; GO:0005788; GO:0005789; GO:0030433; GO:0036498; GO:0051787; GO:0070062 0 0 cd06257; PF00226; Q9ULJ7 CHOYP_LOC578679.4.6 m.38752 sp ANR50_HUMAN 31.774 513 329 3 439 946 578 1074 2.07E-66 247 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VCA8 CHOYP_LOC581927.27.27 m.66337 sp ANKHM_DROME 29.128 539 289 16 759 1284 582 1040 2.07E-39 164 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VHD2 CHOYP_GSTZ1.1.1 m.56540 sp MAAI2_DROME 55.747 174 73 1 2 175 55 224 2.07E-64 200 MAAI2_DROME reviewed Probable maleylacetoacetate isomerase 2 (MAAI 2) (EC 5.2.1.2) (Glutathione S-transferase zeta 2) (EC 2.5.1.18) GstZ2 CG9363 Drosophila melanogaster (Fruit fly) 227 glutathione metabolic process [GO:0006749]; L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] GO:0004364; GO:0005737; GO:0006559; GO:0006572; GO:0006749; GO:0016034 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6. 0 0 PF14497;PF13417; A0A0R4IYX6 CHOYP_LOC100378229.1.2 m.14749 sp Z687A_DANRE 26.933 401 221 15 483 849 550 912 2.08E-30 134 Z687A_DANRE reviewed Zinc finger protein 687a znf687a Danio rerio (Zebrafish) (Brachydanio rerio) 1246 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF16622; A4IF63 CHOYP_TRIM2.14.59 m.27903 sp TRIM2_BOVIN 34.513 113 70 3 31 140 631 742 2.08E-09 58.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NF83 CHOYP_ISCW_ISCW005287.4.6 m.29958 sp NUPR2_HUMAN 41.27 63 36 1 80 142 24 85 2.08E-07 49.3 NUPR2_HUMAN reviewed Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2) NUPR2 NUPR1L Homo sapiens (Human) 97 "cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to starvation [GO:0009267]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003682; GO:0005634; GO:0006351; GO:0006974; GO:0007050; GO:0008285; GO:0009267; GO:0071157 0 0 0 PF10195; E9PVX6 CHOYP_LOC100003868.3.4 m.50092 sp KI67_MOUSE 32.867 143 93 3 13 154 7 147 2.08E-07 58.9 KI67_MOUSE reviewed Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67 homolog) (Antigen KI-67 homolog) (Antigen Ki67 homolog) Mki67 Mus musculus (Mouse) 3177 cell proliferation [GO:0008283]; cellular response to heat [GO:0034605]; cholangiocyte proliferation [GO:1990705]; DNA metabolic process [GO:0006259]; hepatocyte proliferation [GO:0072574]; hyaluronan metabolic process [GO:0030212]; meiotic nuclear division [GO:0007126]; organ regeneration [GO:0031100]; response to organic cyclic compound [GO:0014070] GO:0000775; GO:0000793; GO:0005634; GO:0005730; GO:0005737; GO:0006259; GO:0007126; GO:0008022; GO:0008283; GO:0014070; GO:0016020; GO:0030212; GO:0031100; GO:0034605; GO:0044822; GO:0072574; GO:1990705 0 0 0 PF00498;PF08065;PF15276; H2A0L0 CHOYP_TYRO1.1.6 m.39908 sp TYRO1_PINMG 38.701 354 190 12 45 382 48 390 2.08E-60 214 TYRO1_PINMG reviewed Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 492 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; O08762 CHOYP_BAI1.2.2 m.54647 sp NETR_MOUSE 41.333 300 164 6 5 296 202 497 2.08E-59 223 NETR_MOUSE reviewed Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12) Prss12 Bssp3 Mus musculus (Mouse) 761 exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202 0 0 cd00190; PF00051;PF00530;PF00089; O14788 CHOYP_TNF11.3.3 m.62777 sp TNF11_HUMAN 32.609 138 90 2 207 343 181 316 2.08E-14 76.3 TNF11_HUMAN reviewed "Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]" TNFSF11 OPGL RANKL TRANCE Homo sapiens (Human) 317 activation of JUN kinase activity [GO:0007257]; bone resorption [GO:0045453]; calcium ion homeostasis [GO:0055074]; calcium-mediated signaling [GO:0019722]; cytokine-mediated signaling pathway [GO:0019221]; ERK1 and ERK2 cascade [GO:0070371]; immune response [GO:0006955]; mammary gland alveolus development [GO:0060749]; mammary gland epithelial cell proliferation [GO:0033598]; monocyte chemotaxis [GO:0002548]; organ morphogenesis [GO:0009887]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; osteoclast proliferation [GO:0002158]; paracrine signaling [GO:0038001]; positive regulation of bone resorption [GO:0045780]; positive regulation of corticotropin-releasing hormone secretion [GO:0051466]; positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [GO:0071848]; positive regulation of fever generation by positive regulation of prostaglandin secretion [GO:0071812]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast development [GO:2001206]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of T cell activation [GO:0050870]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein homooligomerization [GO:0051260]; TNFSF11-mediated signaling pathway [GO:0071847]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001503; GO:0002158; GO:0002548; GO:0005125; GO:0005164; GO:0005576; GO:0005615; GO:0005737; GO:0005886; GO:0005887; GO:0006955; GO:0007257; GO:0009887; GO:0019221; GO:0019722; GO:0030316; GO:0032813; GO:0033209; GO:0033598; GO:0034112; GO:0038001; GO:0043123; GO:0043406; GO:0045453; GO:0045672; GO:0045780; GO:0045944; GO:0050870; GO:0051091; GO:0051092; GO:0051260; GO:0051466; GO:0051897; GO:0055074; GO:0060749; GO:0070371; GO:0071812; GO:0071847; GO:0071848; GO:1902533; GO:2001206 0 0 0 PF00229; O35261 CHOYP_E2F3.1.1 m.15290 sp E2F3_MOUSE 48.907 366 135 8 86 444 125 445 2.08E-94 295 E2F3_MOUSE reviewed Transcription factor E2F3 (E2F-3) E2f3 Mus musculus (Mouse) 457 "cell cycle [GO:0007049]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001047; GO:0003677; GO:0003700; GO:0005654; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0007049; GO:0008284; GO:0045893; GO:0070345 0 0 cd14660; PF16421;PF02319; O42646 CHOYP_DFA_05420.1.1 m.25051 sp UBC6_SCHPO 35.821 134 57 7 8 133 4 116 2.08E-11 67.8 UBC6_SCHPO reviewed Ubiquitin-conjugating enzyme E2 6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 6) (Ubiquitin carrier protein 6) (Ubiquitin-protein ligase 6) ubc6 SPAC10F6.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 227 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0005524; GO:0005783; GO:0005789; GO:0016021; GO:0030433; GO:0031625; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; O61199 CHOYP_ODO1.1.2 m.23314 sp ODO1_CAEEL 47.867 211 80 6 4 187 51 258 2.08E-54 188 ODO1_CAEEL reviewed "2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase)" ogdh-1 T22B11.5 Caenorhabditis elegans 1029 generation of precursor metabolites and energy [GO:0006091]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099] GO:0004591; GO:0005739; GO:0005759; GO:0006091; GO:0006096; GO:0006099; GO:0030976; GO:0031966; GO:0045252 0 0 0 PF16078;PF00676;PF16870;PF02779; O75179 CHOYP_LOC100641396.21.27 m.58225 sp ANR17_HUMAN 32.301 452 290 12 810 1247 238 687 2.08E-44 180 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P02556 CHOYP_LOC100367715.1.1 m.65922 sp TBB_LYTPI 95.327 107 5 0 3 109 71 177 2.08E-72 216 TBB_LYTPI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Lytechinus pictus (Painted sea urchin) 177 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P17644 CHOYP_ISCW_ISCW003334.2.2 m.46106 sp ACH2_DROME 36.522 345 205 3 25 359 40 380 2.08E-73 245 ACH2_DROME reviewed Acetylcholine receptor subunit alpha-like 2 (Nicotinic acetylcholine receptor alpha 2) nAChRalpha2 Acr96Ab AcrE nAcRalpha-96Ab sad CG6844 Drosophila melanogaster (Fruit fly) 576 "cation transport [GO:0006812]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0006812; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211 0 0 0 PF02931;PF02932; P35601 CHOYP_contig_013895 m.15807 sp RFC1_MOUSE 36.765 68 36 1 1 68 1045 1105 2.08E-06 47.8 RFC1_MOUSE reviewed Replication factor C subunit 1 (A1-P145) (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (Differentiation-specific element-binding protein) (ISRE-binding protein) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) Rfc1 Ibf-1 Recc1 Mus musculus (Mouse) 1131 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003689; GO:0005524; GO:0005634; GO:0005654; GO:0005663; GO:0006260; GO:0006281; GO:0006351; GO:0006355; GO:0070062 0 0 0 PF00004;PF00533;PF08519; P35822 CHOYP_PTPRZ.5.9 m.24244 sp PTPRK_MOUSE 33.058 121 77 2 4 121 1176 1295 2.08E-12 67.4 PTPRK_MOUSE reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) Ptprk Ptpk Mus musculus (Mouse) 1457 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005911; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; P41095 CHOYP_ISCW_ISCW007303.1.1 m.42263 sp RLA0_ORYSJ 62.245 98 33 2 2 96 221 317 2.08E-21 92.4 RLA0_ORYSJ reviewed 60S acidic ribosomal protein P0 Os08g0130500 LOC_Os08g03640 P0582D05.130-1 Oryza sativa subsp. japonica (Rice) 319 cytoplasmic translation [GO:0002181]; ribosome biogenesis [GO:0042254] GO:0002181; GO:0003735; GO:0022625; GO:0030687; GO:0042254; GO:0070180 0 0 0 PF00466; P42577 CHOYP_ISCW_ISCW023334.1.1 m.66079 sp FRIS_LYMST 45.745 94 49 2 1 94 68 159 2.08E-13 66.2 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P50429 CHOYP_BRAFLDRAFT_206907.7.11 m.42200 sp ARSB_MOUSE 40.393 458 229 8 1 420 81 532 2.08E-113 345 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; P98072 CHOYP_ENTK.1.1 m.61015 sp ENTK_BOVIN 30.324 587 321 21 675 1240 511 1030 2.08E-67 252 ENTK_BOVIN reviewed Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Bos taurus (Bovine) 1035 protein digestion [GO:0044256]; trypsinogen activation [GO:0032023] GO:0004252; GO:0005044; GO:0016020; GO:0016021; GO:0032023; GO:0044256 0 0 cd06263;cd00190; PF00431;PF00057;PF00629;PF01390;PF00530;PF00089; Q04832 CHOYP_RL7.1.2 m.38622 sp HEXP_LEIMA 42.384 151 67 4 55 187 65 213 2.08E-28 109 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q15906 CHOYP_BRAFLDRAFT_167661.1.1 m.11730 sp VPS72_HUMAN 44.411 331 149 8 1 306 3 323 2.08E-75 238 VPS72_HUMAN reviewed Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) VPS72 TCFL1 YL1 Homo sapiens (Human) 364 "covalent chromatin modification [GO:0016569]; histone exchange [GO:0043486]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0016569; GO:0035019; GO:0043234; GO:0043486 0 0 0 PF08265; Q17QR8 CHOYP_BRAFLDRAFT_64464.1.2 m.50916 sp HARB1_BOVIN 44.715 123 68 0 1 123 187 309 2.08E-32 120 HARB1_BOVIN reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 Bos taurus (Bovine) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0005813; GO:0046872 0 0 0 PF13359; Q17QR8 CHOYP_BRAFLDRAFT_64464.2.2 m.58676 sp HARB1_BOVIN 44.715 123 68 0 1 123 187 309 2.08E-32 120 HARB1_BOVIN reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 Bos taurus (Bovine) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0005813; GO:0046872 0 0 0 PF13359; Q1ZXJ0 CHOYP_LOC100186763.1.2 m.3463 sp CLCD_DICDI 44.131 213 118 1 1 213 256 467 2.08E-53 189 CLCD_DICDI reviewed Chloride channel protein D clcD DDB_G0278639 Dictyostelium discoideum (Slime mold) 1000 sorocarp development [GO:0030587] GO:0005247; GO:0030587; GO:0034707 0 0 0 PF00571;PF00654; Q3V0L5 CHOYP_BRAFLDRAFT_125356.2.3 m.20695 sp LRC43_MOUSE 34.219 602 340 13 28 594 27 607 2.08E-72 251 LRC43_MOUSE reviewed Leucine-rich repeat-containing protein 43 Lrrc43 Gm1061 Mus musculus (Mouse) 667 0 0 0 0 0 0 Q56A24 CHOYP_KLH24.1.6 m.23036 sp KLH24_RAT 29.032 465 311 7 118 581 43 489 2.08E-62 222 KLH24_RAT reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) Klhl24 Dre1 Rattus norvegicus (Rat) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q5F464 CHOYP_LOC100368661.1.1 m.60830 sp LPP_CHICK 60.833 240 91 2 281 520 368 604 2.08E-103 325 LPP_CHICK reviewed Lipoma-preferred partner homolog LPP RCJMB04_2l20 Gallus gallus (Chicken) 604 cell adhesion [GO:0007155] GO:0005634; GO:0005737; GO:0005925; GO:0007155; GO:0008270 0 0 0 PF00412; Q5R8I2 CHOYP_CN166.1.1 m.14529 sp CN166_PONAB 56.967 244 104 1 1 244 1 243 2.08E-95 282 CN166_PONAB reviewed UPF0568 protein C14orf166 homolog 0 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 244 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000993; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005815; GO:0005829; GO:0006351; GO:0006388; GO:0044822; GO:0045944; GO:0048471; GO:0072669 0 0 0 PF10036; Q60547 CHOYP_BRAFLDRAFT_117694.1.1 m.12975 sp SYCP3_MESAU 57.068 191 82 0 71 261 44 234 2.08E-71 221 SYCP3_MESAU reviewed Synaptonemal complex protein 3 (SCP-3) (Meiotic chromosome core protein) (Synaptonemal complex protein COR1) SYCP3 COR1 Mesocricetus auratus (Golden hamster) 234 cell division [GO:0051301]; meiotic cell cycle [GO:0051321] GO:0000775; GO:0000800; GO:0003677; GO:0051301; GO:0051321 0 0 0 PF04803; Q61805 CHOYP_LOC589952.3.5 m.29284 sp LBP_MOUSE 25.758 462 324 5 21 474 28 478 2.08E-49 179 LBP_MOUSE reviewed Lipopolysaccharide-binding protein (LBP) Lbp Mus musculus (Mouse) 481 "acute-phase response [GO:0006953]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lipopolysaccharide transport [GO:0015920]; liver development [GO:0001889]; macrophage activation involved in immune response [GO:0002281]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of tumor necrosis factor production [GO:0032720]; opsonization [GO:0008228]; positive regulation of chemokine production [GO:0032722]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage activation [GO:0043032]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of membrane permeability [GO:0090559]; response to lipopolysaccharide [GO:0032496]" GO:0001530; GO:0001889; GO:0002232; GO:0002281; GO:0005102; GO:0005615; GO:0006953; GO:0008228; GO:0009986; GO:0015920; GO:0016020; GO:0031663; GO:0032490; GO:0032496; GO:0032720; GO:0032722; GO:0032755; GO:0032757; GO:0032760; GO:0034145; GO:0042535; GO:0043032; GO:0044130; GO:0045087; GO:0050829; GO:0050830; GO:0060100; GO:0060265; GO:0070062; GO:0070891; GO:0071222; GO:0071223; GO:0090023; GO:0090559 0 0 0 PF01273;PF02886; Q6GPV5 CHOYP_BRAFLDRAFT_285971.1.1 m.18286 sp RN181_XENLA 49.032 155 72 5 1 152 1 151 2.08E-42 140 RN181_XENLA reviewed E3 ubiquitin-protein ligase RNF181 (EC 6.3.2.-) (RING finger protein 181) rnf181 Xenopus laevis (African clawed frog) 156 protein ubiquitination [GO:0016567] GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q6NVF0 CHOYP_NEMVEDRAFT_V1G174916.1.1 m.22957 sp OCRL_MOUSE 36.19 525 313 8 2 512 369 885 2.08E-96 315 OCRL_MOUSE reviewed Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) Ocrl Mus musculus (Mouse) 900 cilium assembly [GO:0042384]; in utero embryonic development [GO:0001701]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165] GO:0001701; GO:0001750; GO:0004439; GO:0005096; GO:0005634; GO:0005737; GO:0005769; GO:0005794; GO:0005802; GO:0005886; GO:0005905; GO:0007165; GO:0030136; GO:0030670; GO:0031901; GO:0042384; GO:0043087; GO:0046856; GO:0048365; GO:0052745; GO:0070062 0 0 0 PF03372;PF16726;PF00620; Q6V0I7 CHOYP_NEMVEDRAFT_V1G197208.1.1 m.44492 sp FAT4_HUMAN 49.541 109 55 0 120 228 3859 3967 2.08E-35 136 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q6ZRF8 CHOYP_LOC100370588.12.19 m.33111 sp RN207_HUMAN 24.02 204 142 5 16 218 103 294 2.08E-10 63.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_LOC100374981.3.16 m.24873 sp RN207_HUMAN 24.878 205 139 6 16 218 103 294 2.08E-13 76.6 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q80V42 CHOYP_CPM.1.1 m.23532 sp CBPM_MOUSE 49.057 159 80 1 9 167 6 163 2.08E-48 165 CBPM_MOUSE reviewed Carboxypeptidase M (CPM) (EC 3.4.17.12) Cpm Mus musculus (Mouse) 443 peptide metabolic process [GO:0006518]; protein processing [GO:0016485] GO:0004181; GO:0004185; GO:0005615; GO:0005886; GO:0006518; GO:0008270; GO:0009986; GO:0016485; GO:0031225; GO:0070062 0 0 0 PF00246; Q8TER0 CHOYP_LOC579589.1.1 m.15593 sp SNED1_HUMAN 48.592 284 129 3 17 299 26 293 2.08E-74 264 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q8WQI5 CHOYP_RS8.11.14 m.57073 sp RS8_SPOFR 72.549 204 54 1 1 204 1 202 2.08E-105 305 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q99NH0 CHOYP_LOC754047.2.3 m.47281 sp ANR17_MOUSE 35.185 324 198 9 14 327 332 653 2.08E-47 175 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BYK8 CHOYP_LOC100369525.1.2 m.32385 sp HELZ2_HUMAN 28.788 1650 993 52 151 1754 1111 2624 2.08E-173 588 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9CZV8 CHOYP_LOC100377240.1.1 m.55823 sp FXL20_MOUSE 29.557 203 128 8 35 225 141 340 2.08E-10 65.9 FXL20_MOUSE reviewed F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) Fbxl20 Fbl2 Mus musculus (Mouse) 436 behavioral fear response [GO:0001662] GO:0001662; GO:0005737 0 0 0 PF12937;PF13516; Q9D5U8 CHOYP_LOC100893884.1.1 m.26838 sp CNBD2_MOUSE 31.5 200 130 3 382 578 187 382 2.08E-19 97.1 CNBD2_MOUSE reviewed Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function) Cnbd2 Cris Mus musculus (Mouse) 673 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q9DC50 CHOYP_LOC753780.1.1 m.23244 sp OCTC_MOUSE 51.648 91 44 0 30 120 12 102 2.08E-25 102 OCTC_MOUSE reviewed Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137) Crot Cot Mus musculus (Mouse) 612 carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791]; response to drug [GO:0042493]; response to organonitrogen compound [GO:0010243] GO:0005102; GO:0005739; GO:0005777; GO:0006091; GO:0006631; GO:0006635; GO:0008458; GO:0009437; GO:0010243; GO:0015908; GO:0015936; GO:0042493; GO:0043231; GO:0051791 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00755; Q9ESN6 CHOYP_TRI27.1.3 m.32497 sp TRIM2_MOUSE 28.834 163 97 7 271 425 536 687 2.08E-06 53.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JHA8 CHOYP_BRAFLDRAFT_63397.6.8 m.48804 sp VWA7_MOUSE 28.367 698 387 28 33 687 44 671 2.08E-53 205 VWA7_MOUSE reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) 891 0 GO:0005576 0 0 0 0 Q9UGM3 CHOYP_LOC100634157.1.1 m.47403 sp DMBT1_HUMAN 44.811 212 107 6 81 286 494 701 2.08E-40 166 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9W6V5 CHOYP_PTPRJ.2.2 m.59242 sp PTPRJ_CHICK 32.092 349 215 6 103 448 1044 1373 2.08E-47 180 PTPRJ_CHICK reviewed Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Supporting-cell antigen) PTPRJ Gallus gallus (Chicken) 1406 negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell adhesion [GO:0045785]; positive regulation of focal adhesion assembly [GO:0051894] GO:0004725; GO:0005886; GO:0005911; GO:0016021; GO:0016791; GO:0032587; GO:0042059; GO:0043407; GO:0045785; GO:0048008; GO:0050860; GO:0051894; GO:0051898 0 0 0 PF00041;PF00102; Q9Z0R4 CHOYP_BRAFLDRAFT_83720.1.1 m.39778 sp ITSN1_MOUSE 61.832 131 49 1 10 140 1583 1712 2.08E-50 175 ITSN1_MOUSE reviewed Intersectin-1 (EH and SH3 domains protein 1) Itsn1 Ese1 Itsn Mus musculus (Mouse) 1714 endocytosis [GO:0006897]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264] GO:0005089; GO:0005509; GO:0005829; GO:0005886; GO:0005905; GO:0006897; GO:0007264; GO:0019209; GO:0030027; GO:0030054; GO:0030139; GO:0032947; GO:0035023; GO:0043005; GO:0043524; GO:0045202; GO:0048013; GO:0051897; GO:0070064 0 0 0 PF00168;PF12763;PF16652;PF00621;PF00018;PF14604; Q9Z2J0 CHOYP_NEMVEDRAFT_V1G82490.1.1 m.65756 sp S23A1_MOUSE 38.961 308 179 3 1 303 273 576 2.08E-68 226 S23A1_MOUSE reviewed Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3) Slc23a1 Svct1 Yspl3 Mus musculus (Mouse) 605 brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid transport [GO:0015882]; lung development [GO:0030324]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]; transepithelial L-ascorbic acid transport [GO:0070904] GO:0005737; GO:0005886; GO:0006814; GO:0007420; GO:0008520; GO:0009636; GO:0009925; GO:0015081; GO:0015229; GO:0015882; GO:0016021; GO:0016324; GO:0030324; GO:0033300; GO:0043229; GO:0070062; GO:0070837; GO:0070890; GO:0070904 0 0 0 PF00860; A2AV25 CHOYP_TL5A.3.3 m.59951 sp FBCD1_MOUSE 44.726 237 114 5 50 270 195 430 2.09E-60 201 FBCD1_MOUSE reviewed Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) 459 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; A7YY35 CHOYP_LOC100376186.6.7 m.62118 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 2.09E-19 98.2 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; A9ULZ2 CHOYP_LOC100702537.1.1 m.50910 sp BIR7B_XENLA 25.714 280 142 5 57 270 65 344 2.09E-22 97.8 BIR7B_XENLA reviewed Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) 345 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; E1BD59 CHOYP_TRI56.3.4 m.14475 sp TRI56_BOVIN 25.397 315 187 12 8 305 18 301 2.09E-11 70.9 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O44252 CHOYP_DWIL_GK23992.1.1 m.46005 sp ROST_DROME 30.769 260 158 8 3 251 8 256 2.09E-26 107 ROST_DROME reviewed Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) 275 myoblast fusion [GO:0007520]; skeletal muscle tissue development [GO:0007519] GO:0007519; GO:0007520; GO:0016020; GO:0016021 0 0 0 0 O70277 CHOYP_ZF_BBOX_RING_-1.8.10 m.53826 sp TRIM3_RAT 27.273 110 74 2 23 127 579 687 2.09E-07 52 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P16157 CHOYP_LOC763941.1.4 m.2971 sp ANK1_HUMAN 32.08 399 242 1 2 371 117 515 2.09E-65 228 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_168010.11.45 m.33085 sp ANK1_HUMAN 28.814 295 190 3 683 975 269 545 2.09E-29 130 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22105 CHOYP_MEG10.70.91 m.54892 sp TENX_HUMAN 26.87 722 353 55 53 699 124 745 2.09E-32 141 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P24044 CHOYP_LOC100015722.1.2 m.16117 sp CALM_PLAFA 45.255 137 74 1 58 193 13 149 2.09E-34 122 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; P48067 CHOYP_SC6A9.4.6 m.26535 sp SC6A9_HUMAN 32.979 94 50 3 2 88 587 674 2.09E-07 51.2 SC6A9_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) SLC6A9 Homo sapiens (Human) 706 "glycine import [GO:0036233]; glycine secretion, neurotransmission [GO:0061537]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0015375; GO:0016020; GO:0036233; GO:0060012; GO:0061537; GO:0098793 0 0 0 PF00209; P50226 CHOYP_ST1C4.3.3 m.27384 sp ST1A2_HUMAN 32.143 252 147 6 53 285 31 277 2.09E-36 135 ST1A2_HUMAN reviewed Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2) SULT1A2 STP2 Homo sapiens (Human) 295 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine biosynthetic process [GO:0009309]; catecholamine metabolic process [GO:0006584]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005829; GO:0006584; GO:0006805; GO:0008146; GO:0008202; GO:0009309; GO:0018958; GO:0047894; GO:0050427; GO:0051923 0 0 0 PF00685; P70490 CHOYP_BRAFLDRAFT_80311.2.3 m.26495 sp MFGM_RAT 38.608 158 82 5 154 309 283 427 2.09E-22 103 MFGM_RAT reviewed Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (O-acetyl GD3 ganglioside synthase) (AGS) (SED1) Mfge8 Ags Rattus norvegicus (Rat) 427 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of cell proliferation [GO:0008284]; response to estrogen [GO:0043627]; single fertilization [GO:0007338] GO:0001525; GO:0005576; GO:0007155; GO:0007338; GO:0008284; GO:0016020; GO:0043627 0 0 0 PF00008;PF00754; Q08DG6 CHOYP_LOC101026589.1.1 m.47613 sp COX15_BOVIN 54.433 406 172 5 22 423 17 413 2.09E-152 441 COX15_BOVIN reviewed Cytochrome c oxidase assembly protein COX15 homolog COX15 Bos taurus (Bovine) 413 heme a biosynthetic process [GO:0006784]; respiratory chain complex IV assembly [GO:0008535] GO:0004129; GO:0005743; GO:0006784; GO:0008535; GO:0016021; GO:0016627; GO:0016653; GO:0070069 0 0 0 PF02628; Q0RBB8 CHOYP_LOC100892236.4.7 m.26529 sp PSUG_FRAAA 41.791 67 38 1 332 398 296 361 2.09E-06 55.1 PSUG_FRAAA reviewed Pseudouridine-5'-phosphate glycosidase (PsiMP glycosidase) (EC 4.2.1.70) psuG FRAAL6645 Frankia alni (strain ACN14a) 361 nucleobase catabolic process [GO:0046113] GO:0004730; GO:0016798; GO:0046113; GO:0046872 0 0 0 PF04227; Q13905 CHOYP_LOC662211.1.1 m.23378 sp RPGF1_HUMAN 40.741 702 314 15 515 1192 447 1070 2.09E-153 491 RPGF1_HUMAN reviewed Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) RAPGEF1 GRF2 Homo sapiens (Human) 1077 activation of MAPKK activity [GO:0000186]; blood vessel development [GO:0001568]; cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of Ras protein signal transduction [GO:0046580]; nerve growth factor signaling pathway [GO:0038180]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; signal transduction [GO:0007165]; single organismal cell-cell adhesion [GO:0016337]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000186; GO:0001568; GO:0005768; GO:0005769; GO:0005829; GO:0007165; GO:0007169; GO:0010976; GO:0016337; GO:0017034; GO:0032486; GO:0038180; GO:0043547; GO:0046580; GO:0048008; GO:0051898; GO:0061028; GO:0070373; GO:0071320; GO:0090090; GO:1901888; GO:1990090; GO:2000178 0 0 cd06224; PF00617;PF00618; Q15262 CHOYP_PTPRK.15.20 m.42351 sp PTPRK_HUMAN 30.756 595 372 16 357 925 858 1438 2.09E-68 253 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q1MSJ5 CHOYP_CSPP1.4.14 m.21209 sp CSPP1_HUMAN 33.842 721 373 24 880 1540 549 1225 2.09E-49 196 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q23023 CHOYP_LOC100644361.1.1 m.6431 sp UNC51_CAEEL 63.664 333 100 3 1 313 1 332 2.09E-127 409 UNC51_CAEEL reviewed Serine/threonine-protein kinase unc-51 (EC 2.7.11.1) (Uncoordinated protein 51) unc-51 Y60A3A.1 Caenorhabditis elegans 856 apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell migration [GO:0016477]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; nematode male tail tip morphogenesis [GO:0045138]; programmed cell death [GO:0012501]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon extension [GO:0030516]; regulation of cell size [GO:0008361]; regulation of multicellular organism growth [GO:0040014]; regulation of protein localization [GO:0032880] GO:0004672; GO:0004674; GO:0005524; GO:0006468; GO:0006914; GO:0007409; GO:0007411; GO:0008340; GO:0008361; GO:0009792; GO:0012501; GO:0016477; GO:0030424; GO:0030516; GO:0032880; GO:0040014; GO:0040024; GO:0043005; GO:0043025; GO:0043277; GO:0045138; GO:0046777; GO:0046872 0 0 0 PF12063;PF00069; Q2KI43 CHOYP_LOC100313571.2.2 m.41182 sp CAV3_BOVIN 44.275 131 72 1 83 212 21 151 2.09E-40 138 CAV3_BOVIN reviewed Caveolin-3 CAV3 Bos taurus (Bovine) 151 actin filament organization [GO:0007015]; cardiac muscle cell development [GO:0055013]; caveola assembly [GO:0070836]; cholesterol homeostasis [GO:0042632]; cytoplasmic microtubule organization [GO:0031122]; detection of muscle stretch [GO:0035995]; establishment of protein localization to plasma membrane [GO:0090002]; glucose homeostasis [GO:0042593]; heart trabecula formation [GO:0060347]; muscle cell cellular homeostasis [GO:0046716]; myoblast fusion [GO:0007520]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell size [GO:0045792]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900826]; negative regulation of nitric-oxide synthase activity [GO:0051001]; negative regulation of sarcomere organization [GO:0060299]; nucleus localization [GO:0051647]; plasma membrane repair [GO:0001778]; positive regulation of myotube differentiation [GO:0010831]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of calcium ion import [GO:0090279]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of nerve growth factor receptor activity [GO:0051394]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein kinase B signaling [GO:0051896]; regulation of signal transduction by receptor internalization [GO:0038009]; regulation of skeletal muscle contraction [GO:0014819]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; triglyceride metabolic process [GO:0006641] GO:0000139; GO:0001778; GO:0002027; GO:0005246; GO:0005783; GO:0005901; GO:0006641; GO:0007015; GO:0007520; GO:0010614; GO:0010831; GO:0014819; GO:0016010; GO:0017015; GO:0017080; GO:0030315; GO:0031122; GO:0035995; GO:0038009; GO:0042383; GO:0042593; GO:0042632; GO:0043407; GO:0045792; GO:0046716; GO:0051001; GO:0051394; GO:0051647; GO:0051896; GO:0051926; GO:0055013; GO:0055117; GO:0060299; GO:0060307; GO:0060347; GO:0060373; GO:0060762; GO:0070836; GO:0090002; GO:0090279; GO:1900744; GO:1900826; GO:1901019; GO:2000649 0 0 0 PF01146; Q2TA29 CHOYP_RAA1E.1.1 m.16616 sp RB11A_BOVIN 55.435 184 82 0 35 218 9 192 2.09E-71 219 RB11A_BOVIN reviewed Ras-related protein Rab-11A RAB11A Bos taurus (Bovine) 216 cell cycle [GO:0007049]; exocytosis [GO:0006887]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005886; GO:0006887; GO:0007049; GO:0007264; GO:0015031; GO:0031175; GO:0032154; GO:0032402; GO:0045335; GO:0055037; GO:0055038; GO:0072659 0 0 0 PF00071; Q3SZ90 CHOYP_EPN4.3.3 m.66577 sp RL13A_BOVIN 57.724 123 52 0 1 123 79 201 2.09E-47 154 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q571C7 CHOYP_BDP1.2.2 m.41421 sp BDP1_MOUSE 32.903 155 94 2 46 197 178 325 2.09E-15 77.4 BDP1_MOUSE reviewed Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) Bdp1 Kiaa1241 Tfnr Mus musculus (Mouse) 2467 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000126; GO:0001026; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355 0 0 0 0 Q58DA1 CHOYP_LOC100492226.2.2 m.11789 sp SPEF1_BOVIN 38.039 255 123 6 30 280 1 224 2.09E-45 156 SPEF1_BOVIN reviewed Sperm flagellar protein 1 SPEF1 Bos taurus (Bovine) 236 0 GO:0005737; GO:0005930; GO:0031514 0 0 0 PF06294; Q5ZLC6 CHOYP_ANKRD10.2.2 m.56856 sp ANR10_CHICK 36.822 258 135 5 8 261 7 240 2.09E-49 172 ANR10_CHICK reviewed Ankyrin repeat domain-containing protein 10 ANKRD10 RCJMB04_6l10 Gallus gallus (Chicken) 414 regulation of canonical Wnt signaling pathway [GO:0060828] GO:0060828 0 0 0 PF12796; Q69Z89 CHOYP_BRAFLDRAFT_85170.1.1 m.8699 sp RADIL_MOUSE 29.467 845 493 16 60 875 83 853 2.09E-86 308 RADIL_MOUSE reviewed Ras-associating and dilute domain-containing protein Radil Kiaa1849 Mus musculus (Mouse) 1099 multicellular organism development [GO:0007275]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0005874; GO:0007165; GO:0007275; GO:0034446 0 0 0 PF01843;PF00595;PF00788; Q6AXP4 CHOYP_LOC100369816.1.1 m.23060 sp CB081_RAT 39.216 153 89 3 5 157 13 161 2.09E-28 121 CB081_RAT reviewed Uncharacterized protein C2orf81 homolog 0 Rattus norvegicus (Rat) 597 0 0 0 0 0 PF15479; Q6DIB5 CHOYP_LOC100371242.5.6 m.58837 sp MEG10_MOUSE 43.919 148 78 3 100 246 349 492 2.09E-24 105 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6F6B3 CHOYP_AFUA_1G01020.26.50 m.33074 sp TANC1_RAT 41.958 143 83 0 1 143 1089 1231 2.09E-24 101 TANC1_RAT reviewed "Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1)" Tanc1 Tanc Rattus norvegicus (Rat) 1849 0 GO:0014069; GO:0030054; GO:0045211 0 0 0 PF12796; Q6ZV70 CHOYP_BRAFLDRAFT_76662.2.3 m.57180 sp LANC3_HUMAN 44.743 409 203 6 40 436 5 402 2.09E-110 334 LANC3_HUMAN reviewed LanC-like protein 3 LANCL3 Homo sapiens (Human) 420 signal transduction [GO:0007165] GO:0003824; GO:0005886; GO:0007165 0 0 0 PF05147; Q7Z5L3 CHOYP_SMC2.4.4 m.59180 sp C1QL2_HUMAN 33.094 139 88 3 282 417 148 284 2.09E-11 67.8 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q80TF3 CHOYP_BRAFLDRAFT_73233.2.2 m.52496 sp PCD19_MOUSE 34.15 694 414 19 26 703 24 690 2.09E-96 335 PCD19_MOUSE reviewed Protocadherin-19 Pcdh19 Kiaa1313 Mus musculus (Mouse) 1145 brain development [GO:0007420]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0007420; GO:0016021 0 0 0 PF00028;PF08266; Q8HXW6 CHOYP_BRAFLDRAFT_128749.1.1 m.56605 sp PPT1_MACFA 63.603 272 99 0 36 307 31 302 2.09E-136 391 PPT1_MACFA reviewed Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) PPT1 QnpA-18851 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 306 cofactor metabolic process [GO:0051186]; cofactor transport [GO:0051181]; lipid catabolic process [GO:0016042]; lysosomal lumen acidification [GO:0007042]; membrane raft organization [GO:0031579]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of neuron apoptotic process [GO:0043524]; nervous system development [GO:0007399]; positive regulation of pinocytosis [GO:0048549]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein depalmitoylation [GO:0002084]; protein transport [GO:0015031] GO:0002084; GO:0005576; GO:0005634; GO:0005764; GO:0005794; GO:0005829; GO:0007042; GO:0007399; GO:0008021; GO:0008474; GO:0015031; GO:0016042; GO:0016290; GO:0030308; GO:0030424; GO:0031579; GO:0043066; GO:0043524; GO:0045121; GO:0048260; GO:0048549; GO:0051181; GO:0051186 0 0 0 PF02089; Q8R087 CHOYP_LOC100693702.1.1 m.8794 sp B4GT7_MOUSE 58.369 233 97 0 65 297 93 325 2.09E-104 311 B4GT7_MOUSE reviewed "Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) [Includes: Xylosylprotein 4-beta-galactosyltransferase (EC 2.4.1.133) (Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I) (UDP-galactose:beta-xylose beta-1,4-galactosyltransferase) (XGPT) (XGalT-1) (Xylosylprotein beta-1,4-galactosyltransferase)]" B4galt7 Xgalt1 Mus musculus (Mouse) 327 extracellular fibril organization [GO:0043206]; glycosaminoglycan biosynthetic process [GO:0006024]; negative regulation of fibroblast proliferation [GO:0048147]; protein N-linked glycosylation [GO:0006487]; proteoglycan metabolic process [GO:0006029] GO:0003831; GO:0005794; GO:0006024; GO:0006029; GO:0006487; GO:0008378; GO:0016021; GO:0030145; GO:0031012; GO:0032580; GO:0043206; GO:0046525; GO:0048147 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02709;PF13733; Q8TCU4 CHOYP_contig_048950 m.58082 sp ALMS1_HUMAN 25.806 217 119 4 2539 2752 3983 4160 2.09E-14 84 ALMS1_HUMAN reviewed Alstrom syndrome protein 1 ALMS1 KIAA0328 Homo sapiens (Human) 4167 endosomal transport [GO:0016197]; G2/M transition of mitotic cell cycle [GO:0000086]; regulation of stress fiber assembly [GO:0051492] GO:0000086; GO:0000922; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0005929; GO:0016197; GO:0051492 0 0 0 PF15309; Q8TEK3 CHOYP_LOC100366496.1.1 m.11889 sp DOT1L_HUMAN 46.757 663 275 15 4 656 6 600 2.09E-174 576 DOT1L_HUMAN reviewed "Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)" DOT1L KIAA1814 KMT4 Homo sapiens (Human) 1739 chromatin silencing [GO:0006342]; histone H3-K79 methylation [GO:0034729]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of JAK-STAT cascade [GO:0046425]; regulation of transcription regulatory region DNA binding [GO:2000677]; telomere organization [GO:0032200] GO:0003677; GO:0005634; GO:0005654; GO:0006342; GO:0008134; GO:0008284; GO:0018024; GO:0031151; GO:0032200; GO:0034729; GO:0042054; GO:0043234; GO:0045944; GO:0046425; GO:0051726; GO:2000677 0 0 0 PF08123; Q99M80 CHOYP_LOC578968.2.2 m.54316 sp PTPRT_MOUSE 45.56 259 136 3 129 386 902 1156 2.09E-62 220 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_69798.17.22 m.53337 sp TRIM2_MOUSE 25.893 224 136 7 76 285 536 743 2.09E-10 64.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GZN1 CHOYP_LOC100376623.1.1 m.63394 sp ARP6_HUMAN 66.304 92 29 1 1 90 178 269 2.09E-32 125 ARP6_HUMAN reviewed Actin-related protein 6 (hArp6) (hARPX) ACTR6 CDA12 Homo sapiens (Human) 396 chromatin remodeling [GO:0006338] GO:0005634; GO:0005737; GO:0005856; GO:0006338 0 0 0 PF00022; Q9HCN4 CHOYP_LOC101071050.1.1 m.38421 sp GPN1_HUMAN 67.089 316 99 1 32 347 11 321 2.09E-148 428 GPN1_HUMAN reviewed GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) GPN1 MBDIN RPAP4 XAB1 HUSSY-23 Homo sapiens (Human) 374 0 GO:0003924; GO:0005525; GO:0005654; GO:0005737; GO:0005739 0 0 0 PF03029; Q9R1R2 CHOYP_TRIM3.45.58 m.47067 sp TRIM3_MOUSE 33.028 109 69 3 38 143 624 731 2.09E-10 61.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9ULJ7 CHOYP_LOC755521.23.28 m.55197 sp ANR50_HUMAN 31.81 569 348 19 101 648 526 1075 2.09E-47 184 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VVE5 CHOYP_MSI2H.3.3 m.35858 sp MSIR6_DROME 56.25 352 123 8 19 366 23 347 2.09E-118 352 MSIR6_DROME reviewed RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) 369 stem cell development [GO:0048864] GO:0000166; GO:0003727; GO:0005737; GO:0005844; GO:0008266; GO:0048864 0 0 0 PF00076; Q9WTS5 CHOYP_BRAFLDRAFT_89790.1.1 m.48378 sp TEN2_MOUSE 34.862 109 55 7 119 222 669 766 2.09E-06 53.5 TEN2_MOUSE reviewed "Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]" Tenm2 Kiaa1127 Odz2 Tnm2 Mus musculus (Mouse) 2764 "axon guidance [GO:0007411]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of filopodium assembly [GO:0051491]; self proteolysis [GO:0097264]; single organismal cell-cell adhesion [GO:0016337]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005102; GO:0005634; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0005911; GO:0006351; GO:0007157; GO:0007411; GO:0016337; GO:0016605; GO:0030054; GO:0030175; GO:0030425; GO:0030426; GO:0035584; GO:0042803; GO:0043005; GO:0043197; GO:0045202; GO:0045211; GO:0046982; GO:0050839; GO:0051491; GO:0097264 0 0 0 PF06484;PF15636; Q9Z221 CHOYP_LOC100377856.1.2 m.13657 sp PMFBP_RAT 25.386 843 555 17 1214 2049 136 911 2.09E-28 129 PMFBP_RAT reviewed Polyamine-modulated factor 1-binding protein 1 (PMF-1-binding protein) (Outer dense fiber protein 3) Pmfbp1 Odf3 Rattus norvegicus (Rat) 971 cytoskeleton organization [GO:0007010] GO:0001520; GO:0007010 0 0 0 0 A1L243 CHOYP_MESD.1.1 m.52095 sp MESD_DANRE 62.573 171 61 2 47 217 34 201 2.10E-72 222 MESD_DANRE reviewed LDLR chaperone MESD (Mesoderm development candidate 2) (Mesoderm development protein) mesdc2 zgc:158636 Danio rerio (Zebrafish) (Brachydanio rerio) 206 Wnt signaling pathway [GO:0016055] GO:0005783; GO:0016055 0 0 0 PF10185; A4IF63 CHOYP_BRAFLDRAFT_87293.1.3 m.20669 sp TRIM2_BOVIN 25.175 143 104 2 47 187 602 743 2.10E-07 54.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8DZE7 CHOYP_D42E1.1.2 m.12607 sp D42E1_DANRE 52.273 352 160 3 8 352 7 357 2.10E-133 390 D42E1_DANRE reviewed Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) sdr42e1 si:ch211-79l17.4 zgc:123280 Danio rerio (Zebrafish) (Brachydanio rerio) 387 steroid biosynthetic process [GO:0006694] GO:0003854; GO:0006694; GO:0016021 0 0 0 PF01073; O75382 CHOYP_LOC100374741.40.83 m.37824 sp TRIM3_HUMAN 26.374 273 170 11 199 454 486 744 2.10E-09 63.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88382 CHOYP_LOC752750.1.1 m.25306 sp MAGI2_RAT 38.359 829 373 17 21 781 6 764 2.10E-158 515 MAGI2_RAT reviewed "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Synaptic-scaffolding molecule) (S-SCAM)" Magi2 Acvrinp1 Aip1 Sscam Rattus norvegicus (Rat) 1277 cellular response to nerve growth factor stimulus [GO:1990090]; glomerular filtration [GO:0003094]; glomerular visceral epithelial cell development [GO:0072015]; mitotic cell cycle arrest [GO:0071850]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein kinase B signaling [GO:0051898]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of receptor internalization [GO:0002092]; protein heterooligomerization [GO:0051291]; receptor clustering [GO:0043113]; SMAD protein signal transduction [GO:0060395] GO:0002092; GO:0003094; GO:0004871; GO:0005634; GO:0005737; GO:0005770; GO:0005886; GO:0005923; GO:0008285; GO:0010976; GO:0014069; GO:0019902; GO:0030159; GO:0030336; GO:0030425; GO:0031697; GO:0032403; GO:0032516; GO:0032926; GO:0036057; GO:0038180; GO:0043113; GO:0043234; GO:0045202; GO:0046332; GO:0048471; GO:0051291; GO:0051898; GO:0060395; GO:0070699; GO:0071850; GO:0072015; GO:1990090 0 0 0 PF00625;PF00595;PF00397; O88992 CHOYP_BRAFLDRAFT_118972.1.1 m.26636 sp C1QRF_MOUSE 28.125 128 78 5 100 222 119 237 2.10E-07 53.5 C1QRF_MOUSE reviewed C1q-related factor (C1q and tumor necrosis factor-related protein 14) (C1q/TNF-related protein 14) (CTRP14) (Complement component 1 Q subcomponent-like 1) C1ql1 C1qrf Crf Ctrp14 Mus musculus (Mouse) 258 maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; neuron remodeling [GO:0016322] GO:0005102; GO:0005581; GO:0005737; GO:0016322; GO:0043083; GO:0044301; GO:0061743; GO:0098793; GO:0099558 0 0 0 PF00386;PF01391; P0A651 CHOYP_LOC100371268.2.2 m.42519 sp Y3154_MYCBO 21.013 395 266 14 432 793 71 452 2.10E-13 77.4 Y3154_MYCBO reviewed Putative diacyglycerol O-acyltransferase Mb3154c (EC 2.3.1.20) (Putative triacylglycerol synthase Mb3154c) Mb3154c Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 463 glycerol metabolic process [GO:0006071]; triglyceride biosynthetic process [GO:0019432] GO:0004144; GO:0006071; GO:0019432 PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. 0 0 PF06974;PF03007; P10242 CHOYP_MYBA.1.1 m.48052 sp MYB_HUMAN 65.054 186 64 1 22 206 10 195 2.10E-82 276 MYB_HUMAN reviewed Transcriptional activator Myb (Proto-oncogene c-Myb) MYB Homo sapiens (Human) 640 "chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H3-K9 methylation [GO:0051574]; positive regulation of T-helper cell differentiation [GO:0045624]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000122; GO:0000278; GO:0000978; GO:0000981; GO:0001077; GO:0001135; GO:0005634; GO:0006338; GO:0006355; GO:0016363; GO:0045624; GO:0045892; GO:0045893; GO:0045944; GO:0051571; GO:0051574 0 0 0 PF09316;PF07988;PF00249; P14198 CHOYP_NEMVEDRAFT_V1G238724.1.1 m.689 sp AAC4_DICDI 31.056 161 87 4 59 203 519 671 2.10E-14 77 AAC4_DICDI reviewed AAC-rich mRNA clone AAC4 protein AAC4 DDB_G0267458 Dictyostelium discoideum (Slime mold) 678 0 GO:0016021 0 0 0 0 P22451 CHOYP_LOC100367353.1.1 m.32093 sp RL5_CHICK 80.932 236 45 0 1 236 1 236 2.10E-144 408 RL5_CHICK reviewed 60S ribosomal protein L5 RPL5 Gallus gallus (Chicken) 297 ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0005925; GO:0006364; GO:0006412; GO:0008097; GO:0016020; GO:0022625; GO:0044822; GO:0070062 0 0 0 PF14204;PF17144; P24862 CHOYP_CCNB1.1.1 m.12902 sp CCNB_PATVU 39.695 262 154 3 202 463 144 401 2.10E-56 196 CCNB_PATVU reviewed G2/mitotic-specific cyclin-B 0 Patella vulgata (Common limpet) 408 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134; P38542 CHOYP_RAN.2.3 m.57308 sp RAN_BRUMA 87.264 212 27 0 36 247 4 215 2.10E-140 395 RAN_BRUMA reviewed GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Bm1_44725 Brugia malayi (Filarial nematode worm) 215 intracellular protein transport [GO:0006886]; nucleocytoplasmic transport [GO:0006913]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0006886; GO:0006913; GO:0007264 0 0 0 PF00071; P42577 CHOYP_FRIS.10.11 m.66054 sp FRIS_LYMST 80 80 16 0 1 80 85 164 2.10E-42 139 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P43143 CHOYP_LOC100215454.1.1 m.40627 sp ACHA6_RAT 33.028 218 134 5 16 223 22 237 2.10E-21 99.8 ACHA6_RAT reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) 493 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of dopamine secretion [GO:0033603]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0033603; GO:0035094; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; Q04831 CHOYP_GLNA2.2.4 m.18980 sp GLNA_PANAR 71.138 246 71 0 1 246 1 246 2.10E-137 394 GLNA_PANAR reviewed Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) 0 Panulirus argus (Caribbean spiny lobster) (Palinurus argus) 361 glutamine biosynthetic process [GO:0006542] GO:0004356; GO:0005524; GO:0005737; GO:0006542 0 0 0 PF00120;PF03951; Q06577 CHOYP_CBLN3.1.2 m.29253 sp HP27_TAMSI 30.081 123 81 2 227 345 93 214 2.10E-09 61.2 HP27_TAMSI reviewed Hibernation-associated plasma protein HP-27 (Hibernator-specific blood complex 27 kDa subunit) 0 Tamias sibiricus (Siberian chipmunk) (Eutamias sibiricus) 215 hibernation [GO:0042750] GO:0005576; GO:0005581; GO:0042750 0 0 0 PF00386;PF01391; Q0VCS4 CHOYP_HOXB2.1.1 m.38596 sp HXA2_BOVIN 82.278 79 13 1 50 127 135 213 2.10E-36 142 HXA2_BOVIN reviewed Homeobox protein Hox-A2 HOXA2 Bos taurus (Bovine) 372 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007275; GO:0043565 0 0 0 PF00046; Q12980 CHOYP_NPRL3.1.1 m.46023 sp NPRL3_HUMAN 45 400 193 6 2 388 4 389 2.10E-107 330 NPRL3_HUMAN reviewed Nitrogen permease regulator 3-like protein (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Protein CGTHBA) NPRL3 C16orf35 CGTHBA MARE Homo sapiens (Human) 569 aorta morphogenesis [GO:0035909]; cardiac muscle tissue development [GO:0048738]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TOR signaling [GO:0032007]; palate development [GO:0060021]; ventricular septum development [GO:0003281] GO:0003281; GO:0005096; GO:0032007; GO:0034198; GO:0035909; GO:0048738; GO:0060021; GO:1990130 0 0 0 PF03666; Q13310 CHOYP_LOC100741783.1.1 m.10160 sp PABP4_HUMAN 82.796 93 16 0 14 106 540 632 2.10E-42 149 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q17RS7 CHOYP_GEN.1.1 m.59522 sp GEN_HUMAN 32.7 526 304 17 1 492 1 510 2.10E-67 236 GEN_HUMAN reviewed Flap endonuclease GEN homolog 1 (EC 3.1.-.-) GEN1 Homo sapiens (Human) 908 double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; resolution of mitotic recombination intermediates [GO:0071140]; resolution of recombination intermediates [GO:0071139] GO:0000724; GO:0003677; GO:0004520; GO:0005654; GO:0005813; GO:0008821; GO:0010824; GO:0046872; GO:0070062; GO:0071139; GO:0071140; GO:0090267 0 0 0 PF00867;PF00752; Q1RMK1 CHOYP_BRAFLDRAFT_57402.1.3 m.12844 sp FA92B_BOVIN 48.416 221 112 1 47 267 6 224 2.10E-72 231 FA92B_BOVIN reviewed Protein FAM92B FAM92B Bos taurus (Bovine) 288 0 0 0 0 0 PF06730; Q32PE0 CHOYP_RPAB2.2.2 m.12061 sp RPAB2_BOVIN 82.979 94 14 1 17 110 36 127 2.10E-51 160 RPAB2_BOVIN reviewed "DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (RPB6 homolog)" POLR2F Bos taurus (Bovine) 127 transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase II promoter [GO:0006366]; transcription from RNA polymerase I promoter [GO:0006360] GO:0003677; GO:0003899; GO:0005634; GO:0005665; GO:0005666; GO:0005736; GO:0006360; GO:0006366; GO:0006383 0 0 0 PF01192; Q3ZBB6 CHOYP_BRAFLDRAFT_87509.1.1 m.19846 sp AP4S1_BOVIN 41.007 139 79 2 26 161 1 139 2.10E-35 123 AP4S1_BOVIN reviewed AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) AP4S1 Bos taurus (Bovine) 144 0 GO:0005794; GO:0005905; GO:0008565 0 0 0 PF01217; Q460N3 CHOYP_PARP15.3.3 m.55313 sp PAR15_HUMAN 30.769 377 214 13 849 1199 103 458 2.10E-32 139 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q460N5 CHOYP_LOC100374497.1.2 m.53654 sp PAR14_HUMAN 30.769 156 102 2 6 160 1039 1189 2.10E-16 79 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q502M6 CHOYP_TVAG_123950.12.31 m.32959 sp ANR29_DANRE 41.216 148 87 0 4 151 53 200 2.10E-31 117 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5R7B4 CHOYP_BRAFLDRAFT_64338.1.2 m.8491 sp STRA6_PONAB 24.808 391 261 9 264 631 279 659 2.10E-30 130 STRA6_PONAB reviewed Stimulated by retinoic acid gene 6 protein homolog STRA6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 667 0 GO:0004872; GO:0005886; GO:0016021; GO:0051183 0 0 0 0 Q5RAS6 CHOYP_LOC100747173.2.2 m.46424 sp COPT1_PONAB 40.553 217 98 7 26 238 1 190 2.10E-41 142 COPT1_PONAB reviewed High affinity copper uptake protein 1 (Copper transporter 1) (Solute carrier family 31 member 1) SLC31A1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 190 0 GO:0005375; GO:0005886; GO:0016021 0 0 0 PF04145; Q6GNM6 CHOYP_LOC100890710.1.1 m.55886 sp F102A_XENLA 39.946 368 169 12 11 344 3 352 2.10E-64 211 F102A_XENLA reviewed Protein FAM102A fam102a Xenopus laevis (African clawed frog) 377 0 0 0 0 0 PF10358; Q6P5M2 CHOYP_WDR61.1.2 m.7565 sp WDR61_DANRE 73.026 304 82 0 6 309 1 304 2.10E-170 477 WDR61_DANRE reviewed WD repeat-containing protein 61 wdr61 zgc:77675 Danio rerio (Zebrafish) (Brachydanio rerio) 305 positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0005634; GO:0005737; GO:0016593; GO:0032968; GO:0035327; GO:0045944; GO:0055087 0 0 0 PF00400; Q6ZRF8 CHOYP_EME1.1.1 m.33089 sp RN207_HUMAN 23.387 248 156 10 13 243 103 333 2.10E-07 57 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7DBF3 CHOYP_LOC100367139.1.1 m.24906 sp GDPPS_ECO57 34.091 132 83 2 82 210 73 203 2.10E-13 74.7 GDPPS_ECO57 reviewed GDP-perosamine synthase (EC 2.6.1.102) perA per rfbE Z3200 ECs2841 Escherichia coli O157:H7 364 O antigen biosynthetic process [GO:0009243] GO:0008483; GO:0009243 PATHWAY: Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. {ECO:0000269|PubMed:8890241}. 0 cd00616; PF01041; Q7TNC8 CHOYP_GLRA2.1.2 m.1309 sp GLRA2_MOUSE 44.282 411 178 8 20 387 39 441 2.10E-113 341 GLRA2_MOUSE reviewed Glycine receptor subunit alpha-2 Glra2 Mus musculus (Mouse) 452 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; response to amino acid [GO:0043200]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0007218; GO:0007416; GO:0016594; GO:0016934; GO:0021510; GO:0022852; GO:0030054; GO:0034220; GO:0034707; GO:0042995; GO:0043200; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; Q80YX1 CHOYP_LOC100636258.1.1 m.65196 sp TENA_MOUSE 42.405 158 86 3 2 159 1944 2096 2.10E-38 142 TENA_MOUSE reviewed Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) 2110 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] GO:0001649; GO:0001968; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; Q86V88 CHOYP_LOC100877618.1.1 m.39871 sp MGDP1_HUMAN 47.436 156 82 0 21 176 1 156 2.10E-49 160 MGDP1_HUMAN reviewed Magnesium-dependent phosphatase 1 (MDP-1) (EC 3.1.3.-) (EC 3.1.3.48) MDP1 Homo sapiens (Human) 176 0 GO:0004725; GO:0046872; GO:0070062 0 0 0 PF12689; Q86WI1 CHOYP_BRAFLDRAFT_78213.1.1 m.7424 sp PKHL1_HUMAN 32.051 156 104 2 5 159 1201 1355 2.10E-19 88.2 PKHL1_HUMAN reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) 4243 immune response [GO:0006955] GO:0004872; GO:0005615; GO:0005829; GO:0006955; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8IWZ3 CHOYP_LOC581927.1.27 m.3919 sp ANKH1_HUMAN 30.37 540 290 18 1 522 223 694 2.10E-46 179 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8K0U4 CHOYP_LOC100488894.5.5 m.58738 sp HS12A_MOUSE 24.749 299 203 6 1 289 382 668 2.10E-25 108 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K2Y0 CHOYP_RN219.2.3 m.18884 sp RN219_MOUSE 46.748 246 121 2 12 247 9 254 2.10E-65 237 RN219_MOUSE reviewed RING finger protein 219 Rnf219 Mus musculus (Mouse) 722 "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" GO:0008270; GO:0048026 0 0 0 0 Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.31.34 m.57875 sp VWDE_HUMAN 24.132 605 368 23 52 608 54 615 2.10E-21 105 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TDB6 CHOYP_LOC100060632.1.3 m.21703 sp DTX3L_HUMAN 48.416 221 104 5 582 795 522 739 2.10E-57 213 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q90YU6 CHOYP_LOC100373289.2.2 m.30860 sp RL22_ICTPU 81.176 85 15 1 1 84 34 118 2.10E-34 118 RL22_ICTPU reviewed 60S ribosomal protein L22 rpl22 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 128 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01776; Q923Y7 CHOYP_LOC100373400.1.1 m.24689 sp TAAR4_RAT 26.733 303 189 11 43 332 44 326 2.10E-09 62 TAAR4_RAT reviewed Trace amine-associated receptor 4 (TaR-4) (Trace amine receptor 4) (2-phenylethylamine receptor) (Trace amine receptor 2) (TaR-2) Taar4 Ta2 Tar2 Trar2 Rattus norvegicus (Rat) 347 behavioral fear response [GO:0001662]; chemosensory behavior [GO:0007635]; sensory perception of chemical stimulus [GO:0007606] GO:0001594; GO:0001662; GO:0005886; GO:0007606; GO:0007635; GO:0008227; GO:0016021; GO:1990080 0 0 0 PF00001; Q92626 CHOYP_PHUM_PHUM184790.1.1 m.41715 sp PXDN_HUMAN 35.893 599 327 20 200 762 737 1314 2.10E-91 317 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q96LR7 CHOYP_contig_056432 m.66953 sp CB050_HUMAN 30.435 92 64 0 28 119 53 144 2.10E-13 65.9 CB050_HUMAN reviewed Uncharacterized protein C2orf50 C2orf50 Homo sapiens (Human) 162 0 0 0 0 0 0 Q96PZ2 CHOYP_LOC100722692.2.2 m.53740 sp F111A_HUMAN 25.095 263 174 9 585 838 334 582 2.10E-07 58.5 F111A_HUMAN reviewed Protein FAM111A FAM111A KIAA1895 Homo sapiens (Human) 611 defense response to virus [GO:0051607]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071] GO:0000785; GO:0005634; GO:0005737; GO:0006260; GO:0045071; GO:0051607 0 0 0 0 Q99NH0 CHOYP_LOC581927.20.27 m.50212 sp ANR17_MOUSE 37.273 220 129 6 343 555 466 683 2.10E-25 115 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9DGB6 CHOYP_LOC101169168.1.1 m.56764 sp TLR22_CHICK 22.315 838 491 35 136 919 49 780 2.10E-19 97.4 TLR22_CHICK reviewed Toll-like receptor 2 type-2 TLR2-2 Gallus gallus (Chicken) 781 detection of bacterial lipoprotein [GO:0042494]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0004872; GO:0004888; GO:0006954; GO:0016021; GO:0031226; GO:0042494; GO:0045087 0 0 0 PF13855;PF01582; Q9ESN6 CHOYP_BRAFLDRAFT_63526.1.2 m.26301 sp TRIM2_MOUSE 23.502 217 151 5 263 474 536 742 2.10E-08 60.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NP73 CHOYP_ALG13.1.1 m.16792 sp ALG13_HUMAN 34.971 346 185 10 7 313 219 563 2.10E-48 188 ALG13_HUMAN reviewed Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (EC 2.4.1.141) (EC 3.4.19.12) (Asparagine-linked glycosylation 13 homolog) (Glycosyltransferase 28 domain-containing protein 1) (UDP-N-acetylglucosamine transferase subunit ALG13 homolog) ALG13 CXorf45 GLT28D1 MDS031 Homo sapiens (Human) 1137 dolichol-linked oligosaccharide biosynthetic process [GO:0006488] GO:0004577; GO:0005789; GO:0006488; GO:0036459; GO:0044822 0 0 0 PF04101;PF02338; Q9NQR1 CHOYP_LOC100881861.1.1 m.61802 sp KMT5A_HUMAN 40.157 127 74 2 32 157 194 319 2.10E-20 90.9 KMT5A_HUMAN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A PRSET7 SET07 SET8 SETD8 Homo sapiens (Human) 393 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006351; GO:0007067; GO:0016278; GO:0016279; GO:0018024; GO:0018026; GO:0042799; GO:0043516; GO:0045892; GO:0051301; GO:1901796 0 0 0 PF00856; Q9ULF5 CHOYP_S39AA.3.3 m.64560 sp S39AA_HUMAN 37.5 504 247 10 125 572 334 825 2.10E-86 288 S39AA_HUMAN reviewed Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) SLC39A10 KIAA1265 ZIP10 Homo sapiens (Human) 831 cellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; zinc II ion transmembrane import [GO:0071578] GO:0002903; GO:0005385; GO:0005887; GO:0006882; GO:0030890; GO:0050861; GO:0071578; GO:1903615 0 0 0 PF02535; Q9UPW6 CHOYP_SATB2.1.1 m.19331 sp SATB2_HUMAN 39.111 225 128 4 61 283 50 267 2.10E-39 152 SATB2_HUMAN reviewed DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) SATB2 KIAA1034 Homo sapiens (Human) 733 "cartilage development [GO:0051216]; cellular response to organic substance [GO:0071310]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; covalent chromatin modification [GO:0016569]; embryonic pattern specification [GO:0009880]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron migration [GO:0001764]; osteoblast development [GO:0002076]; palate development [GO:0060021]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000122; GO:0001764; GO:0002076; GO:0003682; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006338; GO:0006351; GO:0006357; GO:0009880; GO:0016363; GO:0016569; GO:0021902; GO:0043565; GO:0045944; GO:0048704; GO:0051216; GO:0060021; GO:0071310 0 0 0 PF02376;PF16557;PF00046;PF16534; Q9VAY7 CHOYP_FAM50.1.1 m.17123 sp FAM50_DROME 64.365 362 101 5 1 338 1 358 2.10E-160 455 FAM50_DROME reviewed Protein FAM50 homolog CG12259 Drosophila melanogaster (Fruit fly) 359 neurogenesis [GO:0022008] GO:0005654; GO:0022008; GO:0044822 0 0 0 PF04921; Q9XGA0 CHOYP_LOC586661.1.1 m.56660 sp KPRS3_SPIOL 50.654 306 144 3 43 342 100 404 2.10E-108 325 KPRS3_SPIOL reviewed "Ribose-phosphate pyrophosphokinase 3, mitochondrial (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 3)" PRS3 Spinacia oleracea (Spinach) 406 nucleoside metabolic process [GO:0009116]; nucleotide biosynthetic process [GO:0009165] GO:0000287; GO:0004749; GO:0005524; GO:0005739; GO:0009116; GO:0009165; GO:0016301 0 0 cd06223; PF00156;PF13793; Q9Y6E0 CHOYP_BRAFLDRAFT_81321.2.10 m.33301 sp STK24_HUMAN 39.873 158 82 5 795 948 133 281 2.10E-21 102 STK24_HUMAN reviewed Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)] STK24 MST3 STK3 Homo sapiens (Human) 443 cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; mitotic cell cycle [GO:0000278]; negative regulation of cell migration [GO:0030336]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; response to hydrogen peroxide [GO:0042542]; signal transduction [GO:0007165] GO:0000278; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005913; GO:0006468; GO:0006921; GO:0007165; GO:0008631; GO:0016020; GO:0030336; GO:0042542; GO:0046777; GO:0046872; GO:0048679; GO:0070062; GO:0097194; GO:0098641 0 0 0 PF00069; A6QLI0 CHOYP_BRAFLDRAFT_129108.2.2 m.50440 sp EPDR1_BOVIN 29.747 158 102 4 17 168 68 222 2.11E-14 71.6 EPDR1_BOVIN reviewed Mammalian ependymin-related protein 1 (MERP-1) EPDR1 MERP1 Bos taurus (Bovine) 236 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; A8MXY4 CHOYP_ZNF91.1.4 m.7634 sp ZNF99_HUMAN 34.821 672 370 15 69 739 258 862 2.11E-100 340 ZNF99_HUMAN reviewed Zinc finger protein 99 ZNF99 C19orf9 Homo sapiens (Human) 864 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; B0WEV5 CHOYP_ASNA.1.1 m.52208 sp ASNA_CULQU 74.303 323 81 1 18 338 6 328 2.11E-171 483 ASNA_CULQU reviewed ATPase ASNA1 homolog (EC 3.6.-.-) (Arsenical pump-driving ATPase homolog) (Arsenite-stimulated ATPase) CPIJ005690 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) 348 protein insertion into ER membrane [GO:0045048]; transport [GO:0006810] GO:0005524; GO:0005783; GO:0006810; GO:0016887; GO:0045048; GO:0046872 0 0 0 PF02374; B2IZD3 CHOYP_BRAFLDRAFT_81322.1.2 m.17860 sp BDLP_NOSP7 23.86 285 178 11 108 368 72 341 2.11E-11 71.6 BDLP_NOSP7 reviewed Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5) Npun_R6513 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 693 0 GO:0003924; GO:0005525; GO:0005886; GO:0008289; GO:0016021 0 0 0 PF00350; O02827 CHOYP_LOC100367089.2.4 m.1913 sp MYLK_SHEEP 36.607 112 70 1 384 495 311 421 2.11E-15 82.8 MYLK_SHEEP reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) 438 0 GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0030027; GO:0032154; GO:0046872 0 0 0 PF07679;PF00069; O35161 CHOYP_LOC100372197.3.3 m.56377 sp CELR1_MOUSE 25.561 669 378 32 165 757 257 881 2.11E-20 101 CELR1_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 1 Celsr1 Mus musculus (Mouse) 3034 anterior/posterior pattern specification [GO:0009952]; apical protein localization [GO:0045176]; cell-cell signaling [GO:0007267]; central nervous system development [GO:0007417]; establishment of body hair planar orientation [GO:0048105]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; gastrulation with mouth forming second [GO:0001702]; G-protein coupled receptor signaling pathway [GO:0007186]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear morphogenesis [GO:0042472]; lateral sprouting involved in lung morphogenesis [GO:0060490]; locomotory behavior [GO:0007626]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060488]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [GO:0060489]; protein localization involved in establishment of planar polarity [GO:0090251]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of neurotransmitter secretion [GO:0046928]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; wound healing [GO:0042060] GO:0001702; GO:0001736; GO:0001764; GO:0001843; GO:0001942; GO:0004888; GO:0004930; GO:0005509; GO:0005654; GO:0005886; GO:0005887; GO:0007156; GO:0007165; GO:0007186; GO:0007266; GO:0007267; GO:0007417; GO:0007626; GO:0009952; GO:0016020; GO:0032956; GO:0042060; GO:0042249; GO:0042472; GO:0045176; GO:0046928; GO:0046983; GO:0048105; GO:0060488; GO:0060489; GO:0060490; GO:0090179; GO:0090251 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF02793;PF00053;PF02210; O70277 CHOYP_TRIM3.36.58 m.39032 sp TRIM3_RAT 26.482 253 157 12 10 243 465 707 2.11E-12 69.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O73888 CHOYP_LOC100376457.1.2 m.11537 sp HPGDS_CHICK 42.157 204 108 5 27 227 1 197 2.11E-49 163 HPGDS_CHICK reviewed Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase) HPGDS GSTS PGDS PTGDS2 Gallus gallus (Chicken) 199 negative regulation of male germ cell proliferation [GO:2000255]; prostaglandin biosynthetic process [GO:0001516]; prostaglandin metabolic process [GO:0006693] GO:0000287; GO:0001516; GO:0004364; GO:0004667; GO:0005509; GO:0005737; GO:0006693; GO:2000255 0 0 0 PF14497;PF02798; P08060 CHOYP_CAH6.1.1 m.50122 sp CAH6_SHEEP 40.602 266 146 6 22 282 1 259 2.11E-60 196 CAH6_SHEEP reviewed Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase) CA6 Ovis aries (Sheep) 307 one-carbon metabolic process [GO:0006730] GO:0004089; GO:0005576; GO:0006730; GO:0008270 0 0 0 PF00194; P08575 CHOYP_PTPRZ1.1.1 m.24191 sp PTPRC_HUMAN 33.333 72 48 0 92 163 1162 1233 2.11E-10 61.6 PTPRC_HUMAN reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) PTPRC CD45 Homo sapiens (Human) 1304 B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; hematopoietic progenitor cell differentiation [GO:0002244]; immunoglobulin biosynthetic process [GO:0002378]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell proliferation [GO:0042102]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; release of sequestered calcium ion into cytosol [GO:0051209]; stem cell development [GO:0048864]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] GO:0001915; GO:0001960; GO:0002244; GO:0002378; GO:0004725; GO:0005001; GO:0005886; GO:0005887; GO:0005925; GO:0006469; GO:0006470; GO:0006933; GO:0007166; GO:0009897; GO:0009986; GO:0016020; GO:0016311; GO:0019901; GO:0030217; GO:0030890; GO:0042100; GO:0042102; GO:0044770; GO:0045121; GO:0045860; GO:0048539; GO:0048864; GO:0050852; GO:0050853; GO:0050857; GO:0051209; GO:0051607; GO:0051726; GO:0070062; GO:2000473; GO:2000648 0 0 0 PF12567;PF00041;PF12453;PF00102; P15870 CHOYP_KC1A.2.2 m.64031 sp H1D_STRPU 59.459 74 28 1 43 116 32 103 2.11E-20 87 H1D_STRPU reviewed Histone H1-delta 0 Strongylocentrotus purpuratus (Purple sea urchin) 185 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; P18292 CHOYP_TLL2.1.1 m.38543 sp THRB_RAT 32.959 267 161 8 662 918 356 614 2.11E-38 155 THRB_RAT reviewed Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain] F2 Rattus norvegicus (Rat) 617 acute-phase response [GO:0006953]; blood coagulation [GO:0007596]; cellular response to mechanical stimulus [GO:0071260]; positive regulation of blood coagulation [GO:0030194]; response to inactivity [GO:0014854] GO:0004252; GO:0005509; GO:0005615; GO:0006953; GO:0007596; GO:0014854; GO:0030194; GO:0031012; GO:0071260 0 0 cd00190; PF00594;PF00051;PF09396;PF00089; P18700 CHOYP_TBB.5.7 m.60068 sp TBB_STRPU 93.805 113 7 0 1 113 78 190 2.11E-74 225 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P19525 CHOYP_AFUA_5G06750.1.1 m.48232 sp E2AK2_HUMAN 32.372 312 159 8 58 369 267 526 2.11E-33 135 E2AK2_HUMAN reviewed "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)" EIF2AK2 PKR PRKR Homo sapiens (Human) 551 "activation of MAPKK activity [GO:0000186]; cellular response to amino acid starvation [GO:0034198]; defense response to virus [GO:0051607]; endoplasmic reticulum unfolded protein response [GO:0030968]; evasion or tolerance by virus of host immune response [GO:0030683]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; response to exogenous dsRNA [GO:0043330]; response to interferon-alpha [GO:0035455]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to vitamin E [GO:0033197]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0000186; GO:0001819; GO:0003725; GO:0004672; GO:0004674; GO:0004694; GO:0004715; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005840; GO:0006351; GO:0006412; GO:0006468; GO:0008285; GO:0008601; GO:0009612; GO:0009615; GO:0009636; GO:0016020; GO:0017148; GO:0030683; GO:0030968; GO:0032496; GO:0032722; GO:0032874; GO:0033197; GO:0033689; GO:0034198; GO:0035455; GO:0043065; GO:0043066; GO:0043330; GO:0044822; GO:0045071; GO:0045087; GO:0046777; GO:0048471; GO:0051092; GO:0051607; GO:1900225; GO:1901224; GO:1901532; GO:1902033; GO:1902036 0 0 0 PF00035;PF00069; P29084 CHOYP_T2EB.1.1 m.29511 sp T2EB_HUMAN 55.67 291 119 4 1 284 1 288 2.11E-108 318 T2EB_HUMAN reviewed Transcription initiation factor IIE subunit beta (TFIIE-beta) (General transcription factor IIE subunit 2) GTF2E2 TF2E2 Homo sapiens (Human) 291 "regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0003677; GO:0005634; GO:0005654; GO:0005673; GO:0005737; GO:0006355; GO:0006366; GO:0006367; GO:0006368; GO:0042795; GO:0044822 0 0 cd07977; PF02186; P37193 CHOYP_DVIR_GJ13593.1.1 m.18124 sp ADXH_DROME 70.803 137 40 0 45 181 36 172 2.11E-70 213 ADXH_DROME reviewed "Adrenodoxin-like protein, mitochondrial" Fdxh CG4205 Drosophila melanogaster (Fruit fly) 172 oxidation-reduction process [GO:0055114]; positive regulation of ecdysteroid biosynthetic process [GO:0045998]; pupariation [GO:0035073] GO:0005739; GO:0005759; GO:0009055; GO:0035073; GO:0045998; GO:0046872; GO:0051537; GO:0055114 0 0 cd00207; PF00111; Q05695 CHOYP_CRE_31611.1.1 m.58907 sp L1CAM_RAT 24.281 313 211 12 1 306 117 410 2.11E-16 83.2 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q05B60 CHOYP_NUDT14.1.1 m.64313 sp NUD14_BOVIN 44 200 104 2 31 222 1 200 2.11E-56 181 NUD14_BOVIN reviewed Uridine diphosphate glucose pyrophosphatase (UDPG pyrophosphatase) (UGPPase) (EC 3.6.1.45) (Nucleoside diphosphate-linked moiety X motif 14) (Nudix motif 14) NUDT14 UGPP Bos taurus (Bovine) 222 0 GO:0005737; GO:0008768; GO:0046872; GO:0047631; GO:0070062 0 0 0 0 Q0P4W3 CHOYP_BRAFLDRAFT_120481.1.1 m.12564 sp RMD2_XENTR 41.743 218 124 1 149 366 193 407 2.11E-60 203 RMD2_XENTR reviewed Regulator of microtubule dynamics protein 2 (RMD-2) (Protein FAM82A1) rmdn2 fam82a fam82a1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 412 0 GO:0016021 0 0 0 0 Q460N5 CHOYP_BRAFLDRAFT_91321.8.10 m.56532 sp PAR14_HUMAN 32.209 652 388 16 725 1368 1195 1800 2.11E-78 290 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q54KA7 CHOYP_LOC100736798.1.1 m.21820 sp SECG_DICDI 37.288 118 72 1 55 172 407 522 2.11E-13 76.6 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q575T0 CHOYP_CYGB1.1.1 m.58525 sp CYGB1_ORYLA 28.758 153 105 2 19 170 17 166 2.11E-16 75.9 CYGB1_ORYLA reviewed Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 177 0 GO:0005344; GO:0005506; GO:0005737; GO:0019825; GO:0020037 0 0 0 PF00042; Q5R1U3 CHOYP_LOC100493950.1.2 m.6813 sp CYTA3_DICDI 34.454 119 43 3 33 151 11 94 2.11E-13 65.1 CYTA3_DICDI reviewed Cystatin-A3 (VSA745) cpiC DDB_G0277001 Dictyostelium discoideum (Slime mold) 94 hyperosmotic response [GO:0006972]; proteolysis [GO:0006508] GO:0004869; GO:0005737; GO:0006508; GO:0006972 0 0 0 PF00031; Q5RF32 CHOYP_BRAFLDRAFT_90098.3.4 m.11934 sp BHMT2_PONAB 37.126 167 92 5 4 167 11 167 2.11E-27 109 BHMT2_PONAB reviewed S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 363 methionine biosynthetic process [GO:0009086] GO:0005737; GO:0008270; GO:0009086; GO:0047150 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. 0 0 PF02574; Q6DGN0 CHOYP_LOC100163574.1.1 m.22866 sp RERGL_DANRE 41.622 185 100 3 9 188 4 185 2.11E-41 143 RERGL_DANRE reviewed Ras-related and estrogen-regulated growth inhibitor-like protein (RERG/Ras-like protein) rergl zgc:92849 Danio rerio (Zebrafish) (Brachydanio rerio) 205 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0016020 0 0 0 PF00071; Q6NRD5 CHOYP_LOC101167663.1.1 m.40444 sp EXD1_XENLA 34.728 239 151 2 145 381 97 332 2.11E-39 150 EXD1_XENLA reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) exd1 exdl1 Xenopus laevis (African clawed frog) 444 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q6ZRF8 CHOYP_LOC100374974.10.16 m.32934 sp RN207_HUMAN 21.951 205 145 6 18 220 103 294 2.11E-11 67.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_TRI37.2.2 m.61450 sp RN207_HUMAN 21.569 204 146 6 23 224 103 294 2.11E-08 60.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7Z020 CHOYP_LOC100372446.1.1 m.22180 sp TRPA1_DROME 26.452 809 536 21 63 827 86 879 2.11E-57 217 TRPA1_DROME reviewed Transient receptor potential cation channel subfamily A member 1 (dTRPA1) (Ankyrin-like with transmembrane domains protein 1) (dANKTM1) TrpA1 Anktm1 CG5751 Drosophila melanogaster (Fruit fly) 1197 calcium ion transport [GO:0006816]; cation transport [GO:0006812]; cellular response to heat [GO:0034605]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; mechanosensory behavior [GO:0007638]; negative phototaxis [GO:0046957]; neuronal signal transduction [GO:0023041]; phototransduction [GO:0007602]; positive regulation of calcium-mediated signaling [GO:0050850]; response to heat [GO:0009408]; response to light stimulus [GO:0009416]; sensory perception of pain [GO:0019233]; temperature compensation of the circadian clock [GO:0010378]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052] GO:0001580; GO:0005261; GO:0005886; GO:0006812; GO:0006816; GO:0007602; GO:0007638; GO:0009408; GO:0009416; GO:0010378; GO:0015276; GO:0016021; GO:0019233; GO:0023041; GO:0034605; GO:0034703; GO:0040040; GO:0043052; GO:0046957; GO:0050850; GO:0050960; GO:0050965; GO:0050968; GO:0097604 0 0 0 PF00023;PF12796;PF00520; Q7ZTY7 CHOYP_BRAFLDRAFT_125999.1.1 m.24819 sp USE1_DANRE 38.583 254 129 8 16 243 4 256 2.11E-50 168 USE1_DANRE reviewed Vesicle transport protein USE1 (USE1-like protein) use1 use1l zgc:56402 Danio rerio (Zebrafish) (Brachydanio rerio) 258 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0015031; GO:0016021; GO:0016192 0 0 0 PF09753; Q86VM9 CHOYP_ZC3H18.1.1 m.8085 sp ZCH18_HUMAN 38.255 298 118 13 493 747 127 401 2.11E-38 159 ZCH18_HUMAN reviewed Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) ZC3H18 NHN1 Homo sapiens (Human) 953 0 GO:0005654; GO:0044822; GO:0046872 0 0 0 0 Q86Y13 CHOYP_NEMVEDRAFT_V1G233709.2.13 m.31795 sp DZIP3_HUMAN 27.545 167 106 5 28 184 408 569 2.11E-07 57.4 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8VE97 CHOYP_SRSF4.6.6 m.44672 sp SRSF4_MOUSE 49.741 193 92 3 25 216 115 303 2.11E-33 129 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q90421 CHOYP_LOC100634938.1.1 m.7842 sp LHX3_DANRE 31.197 234 153 3 11 244 6 231 2.11E-43 155 LHX3_DANRE reviewed LIM/homeobox protein Lhx3 (LIM homeobox protein 3) (Homeobox protein LIM-3) lhx3 lim3 Danio rerio (Zebrafish) (Brachydanio rerio) 398 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron specification [GO:0021521]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0021521; GO:0043565 0 0 0 PF00046;PF00412; Q96I34 CHOYP_LOC655990.1.1 m.19457 sp PP16A_HUMAN 37.864 103 64 0 53 155 75 177 2.11E-10 63.2 PP16A_HUMAN reviewed Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) PPP1R16A MYPT3 Homo sapiens (Human) 528 0 GO:0005886; GO:0008599 0 0 0 PF12796; Q96MM6 CHOYP_HSPA12A.10.27 m.35252 sp HS12B_HUMAN 32.334 634 353 14 17 583 62 686 2.11E-104 333 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99M15 CHOYP_LOC100923195.1.1 m.1798 sp PPIP2_MOUSE 35.938 128 73 3 4 126 195 318 2.11E-15 75.9 PPIP2_MOUSE reviewed Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2) (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37) Pstpip2 Mayp Mus musculus (Mouse) 334 cell migration [GO:0016477]; cytoskeleton organization [GO:0007010] GO:0003779; GO:0005829; GO:0005856; GO:0007010; GO:0016020; GO:0016477 0 0 0 PF00611; Q9ESN6 CHOYP_LOC100373444.41.79 m.35452 sp TRIM2_MOUSE 29.108 213 117 7 348 543 536 731 2.11E-11 70.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM3.9.58 m.13311 sp TRIM2_MOUSE 29.213 178 114 5 80 251 536 707 2.11E-13 72.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9FSG7 CHOYP_ARALYDRAFT_472154.1.1 m.29819 sp TP1A_MALDO 48.56 243 105 6 1 230 1 236 2.11E-73 226 TP1A_MALDO reviewed Thaumatin-like protein 1a (Mdtl1) (Pathogenesis-related protein 5a) (PR-5a) (allergen Mal d 2) TL1 TL Malus domestica (Apple) (Pyrus malus) 246 0 GO:0005576 0 0 0 PF00314; Q9K623 CHOYP_GEI7407_2980.1.1 m.23705 sp BIOC_BACHD 29.839 124 75 5 167 280 50 171 2.11E-07 55.1 BIOC_BACHD reviewed Malonyl-[acyl-carrier protein] O-methyltransferase (Malonyl-ACP O-methyltransferase) (EC 2.1.1.197) (Biotin synthesis protein BioC) bioC BH3909 Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 271 biotin biosynthetic process [GO:0009102] GO:0009102; GO:0010340 PATHWAY: Cofactor biosynthesis; biotin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00835}. 0 0 0 Q9NQX5 CHOYP_LOC100898516.1.1 m.10598 sp NPDC1_HUMAN 48.092 131 62 5 125 254 181 306 2.11E-32 124 NPDC1_HUMAN reviewed Neural proliferation differentiation and control protein 1 (NPDC-1) NPDC1 Homo sapiens (Human) 325 0 GO:0016021 0 0 0 PF06809; Q9NUW8 CHOYP_TYDP1.1.1 m.46059 sp TYDP1_HUMAN 51.8 500 220 7 183 669 117 608 2.11E-177 521 TYDP1_HUMAN reviewed Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) TDP1 Homo sapiens (Human) 608 DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; single strand break repair [GO:0000012] GO:0000012; GO:0003690; GO:0003697; GO:0004527; GO:0005634; GO:0005737; GO:0005886; GO:0006281; GO:0006302; GO:0017005; GO:0043231 0 0 0 PF06087; Q9NZS9 CHOYP_BFAR.1.2 m.38631 sp BFAR_HUMAN 34.653 202 117 5 22 218 30 221 2.11E-32 125 BFAR_HUMAN reviewed Bifunctional apoptosis regulator (RING finger protein 47) BFAR BAR RNF47 Homo sapiens (Human) 450 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0005783; GO:0005887; GO:0006915; GO:0008270; GO:0016020; GO:0030176; GO:0030674; GO:0042787; GO:0043066; GO:0043161; GO:0051865; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:1903895 0 0 0 PF00536; Q9P209 CHOYP_LOC100375747.1.1 m.36999 sp CEP72_HUMAN 33.128 649 367 14 9 613 8 633 2.11E-86 286 CEP72_HUMAN reviewed Centrosomal protein of 72 kDa (Cep72) CEP72 KIAA1519 Homo sapiens (Human) 647 centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gamma-tubulin complex localization [GO:0033566]; regulation of protein localization to centrosome [GO:1904779]; spindle organization [GO:0007051] GO:0000086; GO:0005813; GO:0005829; GO:0007051; GO:0007099; GO:0033566; GO:0034451; GO:1904779 0 0 0 0 Q9VCZ3 CHOYP_TAAR9.1.1 m.25146 sp OCTB1_DROME 27.157 313 193 8 3 287 112 417 2.11E-28 119 OCTB1_DROME reviewed Octopamine receptor beta-1R (DmOA2) (DmOct-beta-1R) Octbeta1R oa2 Oct-beta-1 CG6919 Drosophila melanogaster (Fruit fly) 508 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; serotonin receptor signaling pathway [GO:0007210] GO:0004935; GO:0004989; GO:0004993; GO:0005887; GO:0007186; GO:0007188; GO:0007189; GO:0007210; GO:0008227; GO:0010579; GO:0016021; GO:0045886 0 0 0 PF00001; A0JPI9 CHOYP_LOC100372392.5.8 m.49607 sp LR74A_RAT 34.228 447 274 8 33 476 41 470 2.12E-79 258 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A6BM72 CHOYP_LOC101075314.2.3 m.60995 sp MEG11_HUMAN 42.336 137 72 4 157 293 566 695 2.12E-18 90.9 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; A6NF83 CHOYP_ISCW_ISCW005287.3.6 m.26649 sp NUPR2_HUMAN 41.27 63 36 1 65 127 24 85 2.12E-07 48.9 NUPR2_HUMAN reviewed Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2) NUPR2 NUPR1L Homo sapiens (Human) 97 "cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to starvation [GO:0009267]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003682; GO:0005634; GO:0006351; GO:0006974; GO:0007050; GO:0008285; GO:0009267; GO:0071157 0 0 0 PF10195; B3EWY9 CHOYP_LOC575161.5.5 m.55590 sp MLP_ACRMI 28.324 1098 621 40 794 1825 368 1365 2.12E-101 365 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; E1BD59 CHOYP_TRIM56.2.2 m.59948 sp TRI56_BOVIN 26.182 275 182 6 17 279 95 360 2.12E-25 115 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; H2A0M3 CHOYP_AMO.5.5 m.66428 sp AMO_PINMG 38.172 186 110 3 44 225 15 199 2.12E-33 130 AMO_PINMG reviewed Putative amine oxidase [copper-containing] (EC 1.4.3.-) 0 Pinctada margaritifera (Black-lipped pearl oyster) 781 amine metabolic process [GO:0009308] GO:0005507; GO:0005576; GO:0008131; GO:0009308; GO:0048038 0 0 0 PF01179; O02827 CHOYP_MYLK.1.4 m.1554 sp MYLK_SHEEP 60.484 124 49 0 1 124 35 158 2.12E-51 171 MYLK_SHEEP reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) 438 0 GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0030027; GO:0032154; GO:0046872 0 0 0 PF07679;PF00069; O05218 CHOYP_NEMVEDRAFT_V1G169538.2.2 m.29703 sp YWRD_BACSU 37.333 300 169 4 1 300 244 524 2.12E-55 190 YWRD_BACSU reviewed Putative gamma-glutamyltransferase YwrD (EC 2.3.2.2) (Glutathione hydrolase) (EC 3.4.19.13) [Cleaved into: Gamma-glutamyltranspeptidase large chain; Gamma-glutamyltranspeptidase small chain] ywrD BSU36100 Bacillus subtilis (strain 168) 525 glutathione metabolic process [GO:0006749] GO:0003840; GO:0006749; GO:0036374 0 0 0 PF01019; O43451 CHOYP_SUIS.2.2 m.16063 sp MGA_HUMAN 44.275 524 266 11 57 575 108 610 2.12E-136 439 MGA_HUMAN reviewed "Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha-glucosidase)]" MGAM MGA MGAML Homo sapiens (Human) 1857 polysaccharide digestion [GO:0044245]; starch catabolic process [GO:0005983] GO:0003824; GO:0004339; GO:0004558; GO:0005886; GO:0005983; GO:0016021; GO:0016160; GO:0016324; GO:0030246; GO:0032450; GO:0044245; GO:0070062 0 0 cd00111; PF01055;PF16863;PF00088; O75382 CHOYP_BRAFLDRAFT_205965.36.43 m.59627 sp TRIM3_HUMAN 27.642 123 86 2 146 266 622 743 2.12E-07 55.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02553 CHOYP_LOC100533261.1.1 m.36143 sp TBA_LYTPI 92.208 77 6 0 75 151 48 124 2.12E-47 154 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P12111 CHOYP_LOC100150496.1.1 m.54037 sp CO6A3_HUMAN 25.455 220 134 6 22 231 1436 1635 2.12E-07 56.2 CO6A3_HUMAN reviewed Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) 3177 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; muscle organ development [GO:0007517] GO:0004867; GO:0005576; GO:0005578; GO:0005589; GO:0005615; GO:0005788; GO:0007155; GO:0007517; GO:0030198; GO:0030574; GO:0031012; GO:0042383; GO:0070062; GO:1903561 0 0 0 PF01391;PF00014;PF00092; P18155 CHOYP_LOC100164363.1.1 m.61731 sp MTDC_MOUSE 64.31 297 106 0 32 328 37 333 2.12E-138 399 MTDC_MOUSE reviewed "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]" Mthfd2 Nmdmc Mus musculus (Mouse) 350 folic acid-containing compound biosynthetic process [GO:0009396]; one-carbon metabolic process [GO:0006730]; tetrahydrofolate metabolic process [GO:0046653] GO:0000287; GO:0004477; GO:0004487; GO:0004488; GO:0005615; GO:0005739; GO:0006730; GO:0009396; GO:0042301; GO:0046653 0 0 0 PF00763;PF02882; P49013 CHOYP_LOC100634060.26.37 m.51943 sp FBP3_STRPU 54.787 188 85 0 7 194 178 365 2.12E-62 224 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P49454 CHOYP_BRAFLDRAFT_217036.1.1 m.66535 sp CENPF_HUMAN 54.464 112 51 0 1 112 1 112 2.12E-31 119 CENPF_HUMAN reviewed Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin) CENPF Homo sapiens (Human) 3210 "cell differentiation [GO:0030154]; cell division [GO:0051301]; cell proliferation [GO:0008283]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; kidney development [GO:0001822]; kinetochore assembly [GO:0051382]; metaphase plate congression [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of transcription, DNA-templated [GO:0045892]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to drug [GO:0042493]; sister chromatid cohesion [GO:0007062]; ventricular system development [GO:0021591]" GO:0000278; GO:0000775; GO:0000776; GO:0000922; GO:0000940; GO:0001822; GO:0003682; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005930; GO:0007059; GO:0007062; GO:0007067; GO:0007094; GO:0007517; GO:0008022; GO:0008134; GO:0008283; GO:0010389; GO:0015031; GO:0016202; GO:0016363; GO:0021591; GO:0030154; GO:0030496; GO:0036064; GO:0042493; GO:0042803; GO:0045120; GO:0045502; GO:0045892; GO:0048471; GO:0051301; GO:0051310; GO:0051382; GO:0051726; GO:0071897; GO:0097539 0 0 0 PF10490;PF10473;PF10481; P54001 CHOYP_LOC101033229.1.1 m.38291 sp P4HA1_RAT 38.75 80 43 1 7 86 334 407 2.12E-07 51.2 P4HA1_RAT reviewed "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4ha1 P4ha Rattus norvegicus (Rat) 534 collagen fibril organization [GO:0030199]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401] GO:0004656; GO:0005506; GO:0005739; GO:0005788; GO:0016020; GO:0016222; GO:0016702; GO:0018401; GO:0030199; GO:0031418 0 0 0 PF13640;PF08336; Q07837 CHOYP_BRAFLDRAFT_265208.4.7 m.23260 sp SLC31_HUMAN 33.279 619 348 21 5 579 53 650 2.12E-93 303 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q15262 CHOYP_LOC100890033.1.1 m.65145 sp PTPRK_HUMAN 27.632 152 104 5 51 197 1209 1359 2.12E-07 53.9 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q2HJ60 CHOYP_LOC100748395.3.7 m.27626 sp ROA2_BOVIN 53.684 190 88 0 18 207 4 193 2.12E-67 217 ROA2_BOVIN reviewed Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Bos taurus (Bovine) 341 "miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; primary miRNA processing [GO:0031053]" GO:0000122; GO:0000166; GO:0000398; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0006406; GO:0016020; GO:0030529; GO:0031053; GO:0035198; GO:0043047; GO:0048025; GO:0070062; GO:0071013; GO:0097157; GO:1990247; GO:1990428 0 0 0 PF00076; Q2VUH7 CHOYP_DIXDC1.2.2 m.66767 sp DIXC1_RAT 62.222 90 34 0 55 144 26 115 2.12E-33 126 DIXC1_RAT reviewed Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) Dixdc1 Ccd1 Rattus norvegicus (Rat) 674 canonical Wnt signaling pathway [GO:0060070]; cerebellar cortex development [GO:0021695]; positive regulation of axonogenesis [GO:0050772]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of JNK cascade [GO:0046330] GO:0005737; GO:0005829; GO:0005925; GO:0021695; GO:0031435; GO:0043015; GO:0043025; GO:0043234; GO:0043679; GO:0046330; GO:0050772; GO:0060070; GO:0090263 0 0 0 PF00307;PF00778; Q39565 CHOYP_BRAFLDRAFT_108792.2.5 m.31493 sp DYHB_CHLRE 26.604 530 322 13 2 522 18 489 2.12E-44 172 DYHB_CHLRE reviewed "Dynein beta chain, flagellar outer arm" ODA4 ODA-4 SUP1 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4568 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0030030; GO:0030286; GO:0031514 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q3TZX8 CHOYP_NOL9.1.2 m.16473 sp NOL9_MOUSE 30.94 585 331 16 362 917 141 681 2.12E-72 256 NOL9_MOUSE reviewed Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9) Nol9 Mus musculus (Mouse) 714 "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of 5.8S rRNA [GO:0000460]" GO:0000448; GO:0000460; GO:0003723; GO:0005524; GO:0005634; GO:0005730; GO:0016020; GO:0051731 0 0 0 PF16575; Q503L9 CHOYP_LOC100378642.1.1 m.54868 sp NXN_DANRE 43.198 419 224 8 1 409 1 415 2.12E-105 320 NXN_DANRE reviewed Nucleoredoxin (EC 1.8.1.8) nxn zgc:110449 Danio rerio (Zebrafish) (Brachydanio rerio) 418 cardiovascular system development [GO:0072358]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005829; GO:0016055; GO:0030154; GO:0030178; GO:0031397; GO:0045454; GO:0047134; GO:0072358 0 0 0 PF13905; Q575T0 CHOYP_NEMVEDRAFT_V1G211636.1.1 m.41609 sp CYGB1_ORYLA 27.451 153 107 2 18 169 12 161 2.12E-12 65.5 CYGB1_ORYLA reviewed Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 177 0 GO:0005344; GO:0005506; GO:0005737; GO:0019825; GO:0020037 0 0 0 PF00042; Q5R3Z6 CHOYP_LTOR3.2.3 m.23767 sp LTOR3_PONAB 57.265 117 49 1 41 157 9 124 2.12E-40 135 LTOR3_PONAB reviewed Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) LAMTOR3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 124 cellular protein localization [GO:0034613]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034613; GO:0043547; GO:0071230; GO:0071986 0 0 0 PF08923; Q5U4U6 CHOYP_LOC100371761.1.1 m.57461 sp T23O_XENLA 39.344 244 131 5 1 228 135 377 2.12E-50 172 T23O_XENLA reviewed "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" tdo2 Xenopus laevis (African clawed frog) 406 tryptophan catabolic process to kynurenine [GO:0019441] GO:0004833; GO:0019441; GO:0020037; GO:0046872 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}. 0 0 PF03301; Q6QMZ4 CHOYP_LOC100203639.1.1 m.22616 sp RL6_CHILA 48.413 252 114 6 2 240 40 288 2.12E-65 207 RL6_CHILA reviewed 60S ribosomal protein L6 RPL6 Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) 288 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01159;PF03868; Q7Q968 CHOYP_LOC101071139.1.1 m.48018 sp NTAQ1_ANOGA 50 184 91 1 7 189 16 199 2.12E-67 207 NTAQ1_ANOGA reviewed Protein N-terminal glutamine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (Protein tungus) tun AGAP004865 Anopheles gambiae (African malaria mosquito) 211 0 GO:0016811 0 0 0 PF09764; Q7SCL1 CHOYP_BRAFLDRAFT_244224.1.1 m.37033 sp GWT1_NEUCR 38.542 288 152 7 5 269 2 287 2.12E-42 154 GWT1_NEUCR reviewed GPI-anchored wall transfer protein 1 (EC 2.3.-.-) gwt1 B13C5.040 NCU00913 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 504 GPI anchor biosynthetic process [GO:0006506] GO:0005789; GO:0006506; GO:0016021; GO:0016746 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF06423; Q7Z6M4 CHOYP_ISCW_ISCW008938.1.1 m.2747 sp MTEF4_HUMAN 31.013 158 107 1 165 320 165 322 2.12E-17 85.5 MTEF4_HUMAN reviewed "Transcription termination factor 4, mitochondrial (Mitochondrial transcription termination factor 4) (MTERF4) (mTERF domain-containing protein 2) [Cleaved into: mTERF domain-containing protein 2 processed]" MTERF4 MTERFD2 HSPC096 Homo sapiens (Human) 381 "camera-type eye development [GO:0043010]; heart development [GO:0007507]; protein targeting to mitochondrion [GO:0006626]; regulation of transcription, DNA-templated [GO:0006355]; ribosome assembly [GO:0042255]; rRNA processing [GO:0006364]; transcription from mitochondrial promoter [GO:0006390]" GO:0003690; GO:0005737; GO:0005739; GO:0005762; GO:0006355; GO:0006364; GO:0006390; GO:0006626; GO:0007507; GO:0019843; GO:0042255; GO:0043010 0 0 0 PF02536; Q80TC5 CHOYP_LOC101155386.1.1 m.30987 sp POGK_MOUSE 34 100 63 2 1 97 224 323 2.12E-11 62.4 POGK_MOUSE reviewed Pogo transposable element with KRAB domain Pogk Kiaa1513 Mus musculus (Mouse) 607 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q80V70 CHOYP_LOC100908128.2.3 m.48080 sp MEGF6_MOUSE 36.287 237 131 11 173 407 1121 1339 2.12E-23 107 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q80W93 CHOYP_LOC100556847.1.1 m.40540 sp HYDIN_MOUSE 50 104 52 0 1 104 714 817 2.12E-28 110 HYDIN_MOUSE reviewed Hydrocephalus-inducing protein (Protein Hy-3) Hydin Hy3 Mus musculus (Mouse) 5154 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; multicellular organism development [GO:0007275]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0007275; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780;PF00635; Q8N2E2 CHOYP_BRAFLDRAFT_80496.3.10 m.22837 sp VWDE_HUMAN 26.359 368 243 12 421 769 749 1107 2.12E-22 107 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8VHN7 CHOYP_GPR98.3.5 m.19963 sp GPR98_MOUSE 32.117 548 333 9 21 564 2876 3388 2.12E-76 268 GPR98_MOUSE reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1) (Neurepin) (Very large G-protein coupled receptor 1) Gpr98 Kiaa0686 Mass1 Vlgr1 Mus musculus (Mouse) 6298 cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; inner ear development [GO:0048839]; inner ear receptor stereocilium organization [GO:0060122]; maintenance of organ identity [GO:0048496]; nervous system development [GO:0007399]; neurological system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; positive regulation of protein kinase A signaling [GO:0010739]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; single organismal cell-cell adhesion [GO:0016337]; visual perception [GO:0007601] GO:0002141; GO:0002142; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0007166; GO:0007399; GO:0007601; GO:0007605; GO:0009986; GO:0010739; GO:0016020; GO:0016021; GO:0016337; GO:0017022; GO:0032391; GO:0043235; GO:0045184; GO:0045494; GO:0048471; GO:0048496; GO:0048839; GO:0050877; GO:0050910; GO:0050953; GO:0060122; GO:0070062; GO:0071277; GO:1990075; GO:1990696 0 0 0 PF00002;PF03160;PF03736; Q8WQA4 CHOYP_DWIL_GK25045.1.2 m.9225 sp EXC4_CAEEL 31.449 283 154 8 121 379 8 274 2.12E-30 121 EXC4_CAEEL reviewed Chloride intracellular channel exc-4 (Excretory canal abnormal protein 4) exc-4 Y105E8A.22 Caenorhabditis elegans 290 chloride transmembrane transport [GO:1902476]; epithelial cell development [GO:0002064]; regulation of tube size [GO:0035150] GO:0002064; GO:0005244; GO:0005254; GO:0005634; GO:0005764; GO:0005887; GO:0016324; GO:0034707; GO:0035150; GO:0043296; GO:1902476 0 0 0 0 Q93425 CHOYP_LOC101155629.1.1 m.30633 sp RT05_CAEEL 33.967 368 228 3 34 390 3 366 2.12E-62 211 RT05_CAEEL reviewed "Putative 28S ribosomal protein S5, mitochondrial" mrps-5 E02A10.1 Caenorhabditis elegans 436 translation [GO:0006412] GO:0003723; GO:0003735; GO:0005763; GO:0006412 0 0 0 PF00333;PF03719; Q95NR9 CHOYP_CALM.22.50 m.31010 sp CALM_METSE 97.987 149 3 0 1 149 1 149 2.12E-102 292 CALM_METSE reviewed Calmodulin (CaM) 0 Metridium senile (Brown sea anemone) (Frilled sea anemone) 149 0 GO:0005509 0 0 0 PF13499; Q96WV6 CHOYP_UAFA.8.8 m.65704 sp YHU2_SCHPO 18.25 663 469 17 290 919 1787 2409 2.12E-08 62.4 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q9BY08 CHOYP_ISCW_ISCW014481.1.1 m.61218 sp EBPL_HUMAN 59.884 172 68 1 23 194 33 203 2.12E-67 208 EBPL_HUMAN reviewed Emopamil-binding protein-like (Emopamil-binding-related protein) EBPL EBRP ERP Homo sapiens (Human) 206 sterol metabolic process [GO:0016125] GO:0005783; GO:0005789; GO:0016021; GO:0016125; GO:0047750 0 0 0 PF05241; Q9CQ46 CHOYP_BRAFLDRAFT_122339.1.1 m.58748 sp EFCB2_MOUSE 63.804 163 58 1 15 176 1 163 2.12E-74 223 EFCB2_MOUSE reviewed EF-hand calcium-binding domain-containing protein 2 Efcab2 Mus musculus (Mouse) 164 0 GO:0005509 0 0 0 0 Q9D2R8 CHOYP_LOC100651698.1.2 m.14150 sp RT33_MOUSE 41.111 90 53 0 1 90 4 93 2.12E-16 71.2 RT33_MOUSE reviewed "28S ribosomal protein S33, mitochondrial (MRP-S33) (S33mt) (Ganglioside-induced differentiation-associated-protein 3)" Mrps33 Gdap3 Mus musculus (Mouse) 106 0 GO:0005739; GO:0005840 0 0 0 PF08293; Q9EQ28 CHOYP_LOC101156197.1.1 m.31571 sp DPOD3_MOUSE 36.646 483 234 19 13 446 3 462 2.12E-60 206 DPOD3_MOUSE reviewed DNA polymerase delta subunit 3 (DNA polymerase delta subunit p66) Pold3 Mus musculus (Mouse) 462 "DNA replication [GO:0006260]; nucleotide-excision repair, DNA gap filling [GO:0006297]" GO:0003887; GO:0005634; GO:0005654; GO:0005739; GO:0006260; GO:0006297 0 0 0 PF09507; Q9ESN6 CHOYP_BRAFLDRAFT_79377.13.30 m.32930 sp TRIM2_MOUSE 24.786 234 156 8 126 349 484 707 2.12E-11 68.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC100373444.6.79 m.3208 sp TRIM2_MOUSE 29.697 165 106 5 343 503 535 693 2.12E-10 67 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC100374741.43.83 m.39040 sp TRIM2_MOUSE 28.216 241 153 9 326 559 516 743 2.12E-16 86.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JHA8 CHOYP_BRAFLDRAFT_63397.1.8 m.4188 sp VWA7_MOUSE 25.21 595 370 23 72 633 91 643 2.12E-28 127 VWA7_MOUSE reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) 891 0 GO:0005576 0 0 0 0 Q9LJN4 CHOYP_LOC100375395.1.2 m.3613 sp BXL5_ARATH 33.513 743 402 21 44 728 11 719 2.12E-112 363 BXL5_ARATH reviewed Probable beta-D-xylosidase 5 (AtBXL5) (EC 3.2.1.-) BXL5 At3g19620 MMB12.15 Arabidopsis thaliana (Mouse-ear cress) 781 carbohydrate metabolic process [GO:0005975] GO:0004553; GO:0005578; GO:0005618; GO:0005975 0 0 0 PF14310;PF00933;PF01915; Q9R0T8 CHOYP_IKK-EPSILON.2.3 m.57318 sp IKKE_MOUSE 32.193 643 376 16 35 648 2 613 2.12E-100 328 IKKE_MOUSE reviewed Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) Ikbke Ikke Ikki Mus musculus (Mouse) 717 cellular response to virus [GO:0098586]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein homooligomerization [GO:0051260]; protein phosphorylation [GO:0006468]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340] GO:0004704; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008384; GO:0008630; GO:0016605; GO:0031625; GO:0031966; GO:0034340; GO:0035456; GO:0036435; GO:0043123; GO:0051260; GO:0098586 0 0 0 PF00069; Q9VAC5 CHOYP_ADA17.3.3 m.54970 sp ADA17_DROME 33.884 726 430 21 5 694 9 720 2.12E-116 372 ADA17_DROME reviewed ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) 732 membrane protein ectodomain proteolysis [GO:0006509] GO:0004222; GO:0006509; GO:0008270; GO:0016021 0 0 0 PF16698;PF00200;PF01562; Q9W2E1 CHOYP_LOC100888890.1.2 m.1882 sp STUM_DROME 36.634 101 60 2 59 155 1741 1841 2.12E-17 86.3 STUM_DROME reviewed Protein stum stum CG30263 Drosophila melanogaster (Fruit fly) 1870 proprioception [GO:0019230]; sensory perception of mechanical stimulus [GO:0050954]; taxis [GO:0042330] GO:0016021; GO:0019230; GO:0030425; GO:0042330; GO:0050954; GO:0071683 0 0 0 PF15795; Q9YIC0 CHOYP_EF-1A.8.9 m.49797 sp EF1A_ORYLA 86.726 113 15 0 17 129 238 350 2.12E-61 197 EF1A_ORYLA reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; A1A4M4 CHOYP_TATD3.2.2 m.14834 sp TATD3_BOVIN 56.767 266 114 1 20 285 7 271 2.13E-102 303 TATD3_BOVIN reviewed Putative deoxyribonuclease TATDN3 (EC 3.1.21.-) TATDN3 Bos taurus (Bovine) 273 0 GO:0004518; GO:0005634; GO:0046872 0 0 0 PF01026; A2AJX4 CHOYP_LOC580670.1.6 m.4085 sp MALR1_MOUSE 36.561 785 423 26 1 764 1356 2086 2.13E-130 432 MALR1_MOUSE reviewed MAM and LDL-receptor class A domain-containing protein 1 Malrd1 Diet1 Gm13318 Mus musculus (Mouse) 2123 cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858] GO:0005737; GO:0016021; GO:0030659; GO:0042632; GO:0070858 0 0 cd06263; PF00057;PF00629; A5YM72 CHOYP_PCKG.1.2 m.43788 sp CRNS1_HUMAN 33.514 185 115 4 3 179 100 284 2.13E-13 71.6 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A7S8T5 CHOYP_LOC100376442.1.1 m.40651 sp CCD42_NEMVE 66.426 277 93 0 1 277 29 305 2.13E-124 360 CCD42_NEMVE reviewed Coiled-coil domain-containing protein 42 homolog v1g187067 Nematostella vectensis (Starlet sea anemone) 312 0 0 0 0 0 PF13863; O35600 CHOYP_LOC101162276.1.1 m.43924 sp ABCA4_MOUSE 26.136 264 185 4 42 299 1 260 2.13E-27 117 ABCA4_MOUSE reviewed Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP) Abca4 Abcr Mus musculus (Mouse) 2310 phospholipid transfer to membrane [GO:0006649]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0001750; GO:0004012; GO:0005524; GO:0005548; GO:0005887; GO:0006649; GO:0007601; GO:0042626; GO:0043231; GO:0045494; GO:0050896 0 0 0 PF00005; O42387 CHOYP_RS24.5.6 m.59485 sp RS24_TAKRU 80.909 110 21 0 5 114 4 113 2.13E-63 192 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O75445 CHOYP_USH2A.3.6 m.14956 sp USH2A_HUMAN 37.024 551 322 13 1 537 3273 3812 2.13E-95 322 USH2A_HUMAN reviewed Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF02210;PF00055; O86034 CHOYP_TMO_0856.2.3 m.30618 sp BDHA_RHIME 35.294 255 163 2 6 259 3 256 2.13E-44 153 BDHA_RHIME reviewed D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) bdhA RB1136 SMb21010 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) 258 0 GO:0003858 0 0 0 0 O88279 CHOYP_LRIG1.3.3 m.56817 sp SLIT1_RAT 36.697 109 65 3 53 160 36 141 2.13E-12 67 SLIT1_RAT reviewed Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) 1531 brain development [GO:0007420]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510] GO:0005509; GO:0005578; GO:0005615; GO:0007420; GO:0008201; GO:0021510; GO:0035385; GO:0043395; GO:0048495; GO:0048843; GO:0051964 0 0 0 PF00008;PF12661;PF02210;PF13855;PF01463;PF01462; P10575 CHOYP_GRXC3.1.1 m.56940 sp GLRX1_BOVIN 39.583 96 54 2 4 97 2 95 2.13E-17 73.9 GLRX1_BOVIN reviewed Glutaredoxin-1 (Thioltransferase) (TTase) GLRX GRX Bos taurus (Bovine) 106 cell redox homeostasis [GO:0045454] GO:0005737; GO:0009055; GO:0015035; GO:0045454 0 0 0 PF00462; P23403 CHOYP_TM9S4.1.1 m.23525 sp RS20_XENLA 92.308 117 7 2 4 118 3 119 2.13E-70 209 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P91891 CHOYP_MO25.1.1 m.62210 sp MO25_DROME 76.558 337 72 4 22 354 1 334 2.13E-168 476 MO25_DROME reviewed Protein Mo25 (dMo25) Mo25 CG4083 Drosophila melanogaster (Fruit fly) 339 embryonic development via the syncytial blastoderm [GO:0001700]; sensory perception of pain [GO:0019233] GO:0001700; GO:0005634; GO:0005737; GO:0019233 0 0 0 PF08569; Q02357 CHOYP_TVAG_099270.2.6 m.54130 sp ANK1_MOUSE 32.011 353 193 3 829 1152 74 408 2.13E-44 180 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q09624 CHOYP_BRAFLDRAFT_92073.2.3 m.36936 sp PKD1_CAEEL 24.717 1060 676 31 1755 2754 2171 3168 2.13E-55 219 PKD1_CAEEL reviewed Location of vulva defective 1 (Polycystic kidney disease 1 protein homolog) (Polycystin-1) lov-1 pkd-1 ZK945.9/ZK945.10 Caenorhabditis elegans 3284 detection of mechanical stimulus [GO:0050982]; male mating behavior [GO:0060179]; mating behavior [GO:0007617]; response to hermaphrodite contact [GO:0034606]; vulval location [GO:0034608] GO:0005262; GO:0005929; GO:0007617; GO:0016020; GO:0016021; GO:0019904; GO:0031513; GO:0034606; GO:0034608; GO:0043025; GO:0050982; GO:0060179 0 0 0 PF08016;PF01477; Q19958 CHOYP_STO2.1.1 m.12048 sp STO2_CAEEL 77.489 231 52 0 2 232 121 351 2.13E-121 352 STO2_CAEEL reviewed Stomatin-2 sto-2 F32A6.5 Caenorhabditis elegans 375 0 GO:0016021 0 0 0 PF01145; Q3EC11 CHOYP_LOC100368376.1.2 m.11023 sp ZDHC2_ARATH 29.273 509 312 11 51 527 28 520 2.13E-66 227 ZDHC2_ARATH reviewed Probable protein S-acyltransferase 23 (EC 2.3.1.225) (Probable palmitoyltransferase At2g14255) (Zinc finger DHHC domain-containing protein At2g14255) PAT23 At2g14255 T1O16.20 Arabidopsis thaliana (Mouse-ear cress) 536 0 GO:0000139; GO:0005794; GO:0008270; GO:0016021; GO:0019706 0 0 0 PF12796;PF01529; Q3T0V9 CHOYP_BRAFLDRAFT_259692.1.1 m.44099 sp DEOC_BOVIN 69.279 319 97 1 12 330 1 318 2.13E-165 466 DEOC_BOVIN reviewed Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) DERA Bos taurus (Bovine) 318 carbohydrate catabolic process [GO:0016052]; deoxyribonucleoside catabolic process [GO:0046121]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386] GO:0004139; GO:0005634; GO:0005737; GO:0009264; GO:0016052; GO:0046121; GO:0046386; GO:0070062 PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. 0 cd00959; PF01791; Q3ZC15 CHOYP_LOC100902369.2.2 m.24414 sp RCAN2_BOVIN 50 112 55 1 2 112 31 142 2.13E-31 115 RCAN2_BOVIN reviewed Calcipressin-2 (Down syndrome candidate region 1-like 1) (Regulator of calcineurin 2) RCAN2 DSCR1L1 Bos taurus (Bovine) 197 calcium-mediated signaling [GO:0019722]; regulation of calcineurin-NFAT signaling cascade [GO:0070884] GO:0000166; GO:0005737; GO:0008597; GO:0019722; GO:0070884 0 0 0 PF04847; Q4PIN7 CHOYP_LOC100880757.2.2 m.41249 sp FKBP4_USTMA 51.064 141 67 2 316 456 233 371 2.13E-35 138 FKBP4_USTMA reviewed FK506-binding protein 4 (EC 5.2.1.8) (Histone proline isomerase) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) FPR4 UMAG_00026 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 375 chaperone-mediated protein folding [GO:0061077]; histone peptidyl-prolyl isomerization [GO:0000412] GO:0000412; GO:0003755; GO:0005528; GO:0005730; GO:0005789; GO:0061077 0 0 0 PF00254; Q4R6P7 CHOYP_PHUM_PHUM285310.1.1 m.38214 sp SESN1_MACFA 44.231 104 56 1 2 103 25 128 2.13E-20 87.4 SESN1_MACFA reviewed Sestrin-1 (EC 1.11.1.15) SESN1 QtsA-17454 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 492 cellular oxidant detoxification [GO:0098869]; cellular response to amino acid stimulus [GO:0071230]; negative regulation of TORC1 signaling [GO:1904262]; reactive oxygen species metabolic process [GO:0072593]; regulation of response to reactive oxygen species [GO:1901031] GO:0005634; GO:0005737; GO:0051920; GO:0070728; GO:0071230; GO:0072593; GO:0098869; GO:1901031; GO:1904262 0 0 0 PF04636; Q502M6 CHOYP_AAEL_AAEL014742.4.8 m.42723 sp ANR29_DANRE 38.596 171 105 0 27 197 59 229 2.13E-36 131 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5FWU8 CHOYP_LOC576498.1.1 m.10455 sp ZMY10_XENLA 50.461 434 209 3 43 473 2 432 2.13E-167 482 ZMY10_XENLA reviewed Zinc finger MYND domain-containing protein 10 zmynd10 Xenopus laevis (African clawed frog) 439 inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158] GO:0005929; GO:0034451; GO:0036158; GO:0036159; GO:0044458; GO:0046872 0 0 0 PF01753; Q5I034 CHOYP_ZGC_162025.1.1 m.66101 sp CL043_RAT 35.659 129 51 4 63 167 75 195 2.13E-09 58.9 CL043_RAT reviewed Uncharacterized protein C12orf43 homolog 0 Rattus norvegicus (Rat) 277 0 0 0 0 0 0 Q5M821 CHOYP_PPM1H.1.1 m.24782 sp PPM1H_RAT 39.746 473 253 4 28 468 36 508 2.13E-116 354 PPM1H_RAT reviewed Protein phosphatase 1H (EC 3.1.3.16) Ppm1h Rattus norvegicus (Rat) 513 0 GO:0004721; GO:0004722; GO:0005634; GO:0005737 0 0 0 PF00481; Q5R7B8 CHOYP_ZBT24.2.2 m.62941 sp KLH20_PONAB 37.097 124 74 3 5 125 40 162 2.13E-15 82.4 KLH20_PONAB reviewed Kelch-like protein 20 KLHL20 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 609 Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005802; GO:0005829; GO:0006895; GO:0015031; GO:0016567; GO:0016605; GO:0019964; GO:0030424; GO:0030425; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6DFV8 CHOYP_BRAFLDRAFT_80496.6.10 m.29014 sp VWDE_MOUSE 29.2 250 153 9 4630 4867 394 631 2.13E-20 103 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6NRD5 CHOYP_EGL.1.3 m.11976 sp EXD1_XENLA 26.63 184 121 7 16 188 113 293 2.13E-06 51.6 EXD1_XENLA reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) exd1 exdl1 Xenopus laevis (African clawed frog) 444 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q6ZMW2 CHOYP_ZN583.1.2 m.8418 sp ZN782_HUMAN 39.914 233 132 4 406 636 466 692 2.13E-45 178 ZN782_HUMAN reviewed Zinc finger protein 782 ZNF782 Homo sapiens (Human) 699 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q6ZNH5 CHOYP_LOC100537049.1.1 m.11978 sp ZN497_HUMAN 35.185 108 66 3 50 155 359 464 2.13E-12 67 ZN497_HUMAN reviewed Zinc finger protein 497 ZNF497 Homo sapiens (Human) 498 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q7TPV2 CHOYP_NEMVEDRAFT_V1G233709.3.13 m.33424 sp DZIP3_MOUSE 37.273 110 53 5 72 173 405 506 2.13E-06 50.4 DZIP3_MOUSE reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) 1204 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q7Z0T3 CHOYP_SMP_137640.2.2 m.43883 sp TEMPT_APLCA 42.697 89 49 2 3 89 7 95 2.13E-13 65.9 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q80X08 CHOYP_BRAFLDRAFT_118099.6.6 m.45150 sp FAM21_RAT 37.183 788 353 34 27 750 17 726 2.13E-78 289 FAM21_RAT reviewed WASH complex subunit FAM21 Fam21 Rattus norvegicus (Rat) 1328 "retrograde transport, endosome to Golgi [GO:0042147]" GO:0005769; GO:0005829; GO:0005886; GO:0031901; GO:0042147; GO:0071203 0 0 0 PF15255; Q8NEN9 CHOYP_DPSE_GA10273.1.1 m.25053 sp PDZD8_HUMAN 29.327 208 120 3 239 440 702 888 2.13E-20 99.8 PDZD8_HUMAN reviewed PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) PDZD8 PDZK8 Homo sapiens (Human) 1154 cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; regulation of cell morphogenesis [GO:0022604]; viral process [GO:0016032] GO:0005622; GO:0007010; GO:0016020; GO:0016032; GO:0022604; GO:0035556; GO:0046872 0 0 0 PF00130;PF00595; Q93131 CHOYP_ACTC.4.6 m.25285 sp ACTC_BRAFL 79.554 269 49 2 6 273 1 264 2.13E-160 454 ACTC_BRAFL reviewed "Actin, cytoplasmic (BfCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma floridae (Florida lancelet) (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96GP6 CHOYP_MEG11.11.25 m.42856 sp SREC2_HUMAN 39.831 118 65 4 1 116 254 367 2.13E-16 84 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q96M86 CHOYP_BRAFLDRAFT_102423.2.2 m.37971 sp DNHD1_HUMAN 25.586 555 335 16 247 796 2026 2507 2.13E-33 143 DNHD1_HUMAN reviewed Dynein heavy chain domain-containing protein 1 (Dynein heavy chain domain 1-like protein) (Protein CCDC35) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) 4753 microtubule-based movement [GO:0007018] GO:0003777; GO:0007018; GO:0030286; GO:0070062 0 0 0 PF08393;PF03028;PF12777; Q99M80 CHOYP_MEG10.79.91 m.59237 sp PTPRT_MOUSE 43.386 189 104 2 560 747 882 1068 2.13E-39 160 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_255103.7.18 m.34576 sp TRIM2_MOUSE 25 252 176 6 87 329 484 731 2.13E-13 74.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JIP0 CHOYP_TRPV5.2.3 m.35830 sp TRPV5_RAT 26.7 603 345 16 95 674 73 601 2.13E-37 154 TRPV5_RAT reviewed Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transporter 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) Trpv5 Cat2 Ecac Ecac1 Rattus norvegicus (Rat) 723 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein tetramerization [GO:0051262] GO:0005262; GO:0005887; GO:0006816; GO:0016324; GO:0051262; GO:0060402 0 0 0 PF12796;PF00520; Q9R0T8 CHOYP_LOC100881707.1.1 m.4017 sp IKKE_MOUSE 46.721 122 65 0 1 122 110 231 2.13E-33 125 IKKE_MOUSE reviewed Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) Ikbke Ikke Ikki Mus musculus (Mouse) 717 cellular response to virus [GO:0098586]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein homooligomerization [GO:0051260]; protein phosphorylation [GO:0006468]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340] GO:0004704; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008384; GO:0008630; GO:0016605; GO:0031625; GO:0031966; GO:0034340; GO:0035456; GO:0036435; GO:0043123; GO:0051260; GO:0098586 0 0 0 PF00069; Q9Y493 CHOYP_contig_040909 m.46521 sp ZAN_HUMAN 44.253 174 76 1 72 224 580 753 2.13E-10 63.5 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; Q9Y5W5 CHOYP_LOC100893086.1.1 m.25627 sp WIF1_HUMAN 37.805 82 49 2 64 143 232 313 2.13E-13 77 WIF1_HUMAN reviewed Wnt inhibitory factor 1 (WIF-1) WIF1 UNQ191/PRO217 Homo sapiens (Human) 379 multicellular organism development [GO:0007275]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] GO:0005576; GO:0007165; GO:0007275; GO:0016055; GO:0017147; GO:0030178; GO:0045600 0 0 0 PF12661;PF02019; Q9Z1Z3 CHOYP_EPN2.1.1 m.23660 sp EPN2_RAT 46.154 559 218 21 7 534 6 512 2.13E-126 386 EPN2_RAT reviewed Epsin-2 (EPS-15-interacting protein 2) Epn2 Rattus norvegicus (Rat) 583 endocytosis [GO:0006897]; regulation of endocytosis [GO:0030100] GO:0006897; GO:0008289; GO:0030100; GO:0030128 0 0 0 PF01417; A0JPI9 CHOYP_LOC582270.2.2 m.34500 sp LR74A_RAT 30.201 447 293 8 39 480 37 469 2.14E-63 219 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A2ASS6 CHOYP_LOC100367089.1.4 m.1386 sp TITIN_MOUSE 26.714 1269 765 23 1133 2374 6965 8095 2.14E-107 392 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A6QLI0 CHOYP_BRAFLDRAFT_129110.1.2 m.50664 sp EPDR1_BOVIN 30.46 174 112 4 17 184 52 222 2.14E-20 88.2 EPDR1_BOVIN reviewed Mammalian ependymin-related protein 1 (MERP-1) EPDR1 MERP1 Bos taurus (Bovine) 236 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; B3DLU1 CHOYP_NCALD.1.1 m.14659 sp NCALD_XENTR 52.91 189 85 4 1 187 1 187 2.14E-66 204 NCALD_XENTR reviewed Neurocalcin-delta ncald Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 193 0 GO:0005509 0 0 0 PF13499;PF13833; B3EWY9 CHOYP_contig_051797 m.62019 sp MLP_ACRMI 28.625 1069 597 41 832 1831 394 1365 2.14E-95 347 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O43734 CHOYP_PAR15.2.6 m.21081 sp CIKS_HUMAN 33.548 155 94 5 510 661 411 559 2.14E-20 99 CIKS_HUMAN reviewed Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 Homo sapiens (Human) 574 B cell apoptotic process [GO:0001783]; humoral immune response [GO:0006959]; immunoglobulin secretion [GO:0048305]; intracellular signal transduction [GO:0035556]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0001783; GO:0002230; GO:0005622; GO:0006959; GO:0035556; GO:0043123; GO:0048305 0 0 0 PF08357; O44252 CHOYP_LOC754845.3.3 m.57150 sp ROST_DROME 26.459 257 175 7 54 299 17 270 2.14E-22 97.4 ROST_DROME reviewed Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) 275 myoblast fusion [GO:0007520]; skeletal muscle tissue development [GO:0007519] GO:0007519; GO:0007520; GO:0016020; GO:0016021 0 0 0 0 O54916 CHOYP_REPS1.1.2 m.35334 sp REPS1_MOUSE 40.704 199 104 5 336 525 274 467 2.14E-31 135 REPS1_MOUSE reviewed RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1) Reps1 Mus musculus (Mouse) 795 0 GO:0005509; GO:0005886; GO:0005905; GO:0017124 0 0 0 PF12763; O88271 CHOYP_HHEX.2.2 m.19527 sp CFDP1_MOUSE 45.763 295 145 6 3 291 5 290 2.14E-58 192 CFDP1_MOUSE reviewed Craniofacial development protein 1 (27 kDa craniofacial protein) (Bucentaur) (Protein Cp27) Cfdp1 Bcnt Cfdp Cp27 Mus musculus (Mouse) 295 cell adhesion [GO:0007155]; multicellular organism development [GO:0007275]; negative regulation of fibroblast apoptotic process [GO:2000270]; regulation of cell proliferation [GO:0042127]; regulation of cell shape [GO:0008360] GO:0000777; GO:0005604; GO:0007155; GO:0007275; GO:0008360; GO:0042127; GO:2000270 0 0 0 PF07572; P0CW97 CHOYP_LOC100370161.5.5 m.59216 sp PCR3_ARATH 36.893 103 59 2 2 98 14 116 2.14E-13 65.1 PCR3_ARATH reviewed Protein PLANT CADMIUM RESISTANCE 3 (AtPCR3) PCR3 At5g35525 MOK9 Arabidopsis thaliana (Mouse-ear cress) 152 0 GO:0016021 0 0 0 PF04749; P43254 CHOYP_SMP_141490.1.1 m.26902 sp COP1_ARATH 33.824 68 45 0 6 73 50 117 2.14E-07 51.6 COP1_ARATH reviewed E3 ubiquitin-protein ligase COP1 (EC 6.3.2.-) (Constitutive photomorphogenesis protein 1) COP1 At2g32950 T21L14.11 Arabidopsis thaliana (Mouse-ear cress) 675 "anthocyanin-containing compound metabolic process [GO:0046283]; DNA repair [GO:0006281]; entrainment of circadian clock [GO:0009649]; photomorphogenesis [GO:0009640]; photoperiodism, flowering [GO:0048573]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; red, far-red light phototransduction [GO:0009585]; regulation of stomatal movement [GO:0010119]; shade avoidance [GO:0009641]; skotomorphogenesis [GO:0009647]" GO:0000152; GO:0004842; GO:0005634; GO:0005737; GO:0006281; GO:0008270; GO:0009585; GO:0009640; GO:0009641; GO:0009647; GO:0009649; GO:0010119; GO:0016604; GO:0016874; GO:0032436; GO:0042802; GO:0046283; GO:0048573; GO:0061630; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; P62264 CHOYP_RS14.5.6 m.55188 sp RS14_MOUSE 89.286 140 14 1 1 139 1 140 2.14E-89 259 RS14_MOUSE reviewed 40S ribosomal protein S14 Rps14 Mus musculus (Mouse) 151 "erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]" GO:0000028; GO:0000122; GO:0000462; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005739; GO:0005925; GO:0006412; GO:0016020; GO:0022627; GO:0030218; GO:0030490; GO:0044822; GO:0045182; GO:0048027; GO:0070062; GO:0070181 0 0 0 PF00411; P62264 CHOYP_ZSWM8.1.1 m.17642 sp RS14_MOUSE 89.286 140 14 1 1 139 1 140 2.14E-89 259 RS14_MOUSE reviewed 40S ribosomal protein S14 Rps14 Mus musculus (Mouse) 151 "erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]" GO:0000028; GO:0000122; GO:0000462; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005739; GO:0005925; GO:0006412; GO:0016020; GO:0022627; GO:0030218; GO:0030490; GO:0044822; GO:0045182; GO:0048027; GO:0070062; GO:0070181 0 0 0 PF00411; P63269 CHOYP_A1.1.1 m.38449 sp ACTH_RAT 92.683 41 3 0 36 76 321 361 2.14E-19 84.3 ACTH_RAT reviewed "Actin, gamma-enteric smooth muscle (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin)" Actg2 Acta3 Actsg Rattus norvegicus (Rat) 376 mesenchyme migration [GO:0090131]; positive regulation of gene expression [GO:0010628] GO:0005524; GO:0005737; GO:0010628; GO:0030027; GO:0030175; GO:0032982; GO:0044297; GO:0070062; GO:0071944; GO:0072562; GO:0090131 0 0 0 PF00022; Q02858 CHOYP_TIE2.1.6 m.33140 sp TIE2_MOUSE 26.111 180 111 6 27 195 267 435 2.14E-06 50.8 TIE2_MOUSE reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b) Tek Hyk Tie-2 Tie2 Mus musculus (Mouse) 1122 angiogenesis [GO:0001525]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; patterning of blood vessels [GO:0001569]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cytokine secretion involved in immune response [GO:0002741]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of endothelial cell proliferation [GO:0001936]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of NIK/NF-kappaB signaling [GO:1901222]; response to retinoic acid [GO:0032526]; single organismal cell-cell adhesion [GO:0016337]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570] GO:0001525; GO:0001569; GO:0001570; GO:0001934; GO:0001935; GO:0001936; GO:0002040; GO:0002741; GO:0004713; GO:0004714; GO:0004872; GO:0005524; GO:0005576; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007160; GO:0007169; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016021; GO:0016323; GO:0016324; GO:0016337; GO:0016525; GO:0018108; GO:0030097; GO:0030334; GO:0030949; GO:0032526; GO:0032878; GO:0033138; GO:0034446; GO:0042307; GO:0043066; GO:0043552; GO:0045121; GO:0045765; GO:0045766; GO:0045785; GO:0046777; GO:0048014; GO:0048471; GO:0050900; GO:0051259; GO:0051894; GO:0051897; GO:0060347; GO:0070374; GO:1901222; GO:1902533; GO:2000251; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q12912 CHOYP_LOC100379008.3.4 m.45821 sp LRMP_HUMAN 29.651 344 187 9 1219 1543 207 514 2.14E-31 134 LRMP_HUMAN reviewed Lymphoid-restricted membrane protein (Protein Jaw1) [Cleaved into: Processed lymphoid-restricted membrane protein] LRMP JAW1 Homo sapiens (Human) 555 immune system process [GO:0002376]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903] GO:0000922; GO:0002376; GO:0005635; GO:0005694; GO:0005789; GO:0005815; GO:0005887; GO:0006903; GO:0006906; GO:0007338; GO:0016020; GO:0016021 0 0 0 PF05781; Q1G7G9 CHOYP_LOC100369084.1.1 m.12940 sp TALD3_CHICK 28.969 611 334 21 815 1379 498 1054 2.14E-42 175 TALD3_CHICK reviewed TALPID3 protein TALPID3 Gallus gallus (Chicken) 1523 centrosome localization [GO:0051642]; cilium assembly [GO:0042384]; motile cilium assembly [GO:0044458]; regulation of establishment of protein localization [GO:0070201]; smoothened signaling pathway [GO:0007224] GO:0005737; GO:0005813; GO:0005814; GO:0007224; GO:0036064; GO:0042384; GO:0044458; GO:0051642; GO:0070201 0 0 0 PF15324; Q1L8J7 CHOYP_YAP.2.2 m.62060 sp YAP1_DANRE 39.095 486 205 21 10 458 11 442 2.14E-75 246 YAP1_DANRE reviewed Transcriptional coactivator YAP1 (Yes-associated protein 1) (zYAP) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) yap1 CH211-181P1.5-001 Danio rerio (Zebrafish) (Brachydanio rerio) 442 "dorsal/ventral axis specification [GO:0009950]; embryonic hemopoiesis [GO:0035162]; heart formation [GO:0060914]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0009950; GO:0010629; GO:0035162; GO:0043066; GO:0060914 0 0 0 PF00397; Q29HY3 CHOYP_LOC100872736.1.1 m.30203 sp CDC42_DROPS 37.173 191 101 4 7 179 2 191 2.14E-35 125 CDC42_DROPS reviewed Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) 191 maintenance of protein location [GO:0045185]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275; GO:0045185; GO:0045860 0 0 0 PF00071; Q5IS54 CHOYP_CASP7.6.23 m.15244 sp CASP3_PANTR 45.635 252 127 3 26 277 7 248 2.14E-71 223 CASP3_PANTR reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Pan troglodytes (Chimpanzee) 277 B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to DNA damage stimulus [GO:0006974]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; keratinocyte differentiation [GO:0030216]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; protein processing [GO:0016485]; response to UV [GO:0009411]; response to wounding [GO:0009611]; sensory perception of sound [GO:0007605]; T cell homeostasis [GO:0043029] GO:0001782; GO:0004190; GO:0004861; GO:0005634; GO:0005737; GO:0005829; GO:0006974; GO:0007507; GO:0007605; GO:0009411; GO:0009611; GO:0016485; GO:0030182; GO:0030216; GO:0030218; GO:0030889; GO:0034349; GO:0043029; GO:0043066; GO:0045165; GO:0045736; GO:0046007; GO:0048011; GO:0051402; GO:0097194; GO:0097200 0 0 0 0 Q61143 CHOYP_TRPC6.1.2 m.43781 sp TRPC6_MOUSE 38.417 518 260 10 9 483 5 506 2.14E-103 332 TRPC6_MOUSE reviewed Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel) (Transient receptor protein 6) (TRP-6) Trpc6 Trp6 Trrp6 Mus musculus (Mouse) 930 aging [GO:0007568]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; manganese ion transport [GO:0006828]; negative regulation of dendrite morphogenesis [GO:0050774]; neuron differentiation [GO:0030182]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; single fertilization [GO:0007338] GO:0005216; GO:0005737; GO:0005886; GO:0005887; GO:0006828; GO:0007204; GO:0007338; GO:0007568; GO:0010800; GO:0015279; GO:0016020; GO:0030182; GO:0032414; GO:0036057; GO:0045666; GO:0050774; GO:0051928; GO:0070301; GO:0070679; GO:0071456 0 0 0 PF12796;PF00520;PF08344; Q66H59 CHOYP_NPL.1.3 m.4064 sp NPL_RAT 38.832 291 169 5 9 292 3 291 2.14E-63 205 NPL_RAT reviewed N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) Npl Rattus norvegicus (Rat) 320 carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262] GO:0005737; GO:0005975; GO:0008747; GO:0019262 PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. 0 0 PF00701; Q66S13 CHOYP_DANA_GF21233.3.3 m.38097 sp NATT4_THANI 30.469 128 81 3 19 146 85 204 2.14E-06 49.3 NATT4_THANI reviewed Natterin-4 (EC 3.4.-.-) 0 Thalassophryne nattereri (Niquim) 387 0 GO:0005576; GO:0016787 0 0 0 PF11901; Q6P132 CHOYP_TXB1B.1.1 m.48405 sp TXB1B_DANRE 30.714 140 86 4 1 134 1 135 2.14E-09 64.3 TXB1B_DANRE reviewed Tax1-binding protein 1 homolog B tax1bp1b tax1bp1 zgc:77129 Danio rerio (Zebrafish) (Brachydanio rerio) 823 apoptotic process [GO:0006915] GO:0006915; GO:0046872 0 0 0 PF07888; Q6P7A9 CHOYP_LYAG.1.2 m.10529 sp LYAG_RAT 39.623 318 165 13 4 317 5 299 2.14E-53 191 LYAG_RAT reviewed Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) Gaa Rattus norvegicus (Rat) 953 glycogen catabolic process [GO:0005980] GO:0004558; GO:0005764; GO:0005765; GO:0005980; GO:0030246; GO:0032450 0 0 cd00111; PF13802;PF01055;PF16863;PF00088; Q6PAY6 CHOYP_PROD2.2.3 m.60644 sp PROD2_XENLA 40.541 370 216 4 63 432 53 418 2.14E-95 297 PROD2_XENLA reviewed Probable proline dehydrogenase 2 (EC 1.5.5.2) (Probable proline oxidase 2) prodh2 Xenopus laevis (African clawed frog) 466 proline catabolic process to glutamate [GO:0010133] GO:0004657; GO:0010133 PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2. 0 0 PF01619; Q6PCJ1 CHOYP_BRAFLDRAFT_83826.1.1 m.62225 sp DCTN1_XENLA 36.522 115 52 2 7 121 10 103 2.14E-13 72.4 DCTN1_XENLA reviewed Dynactin subunit 1 dctn1 Xenopus laevis (African clawed frog) 1232 cytoplasmic microtubule organization [GO:0031122]; establishment of localization by movement along microtubule [GO:0010970]; positive regulation of intracellular protein transport [GO:0090316] GO:0003774; GO:0005737; GO:0005813; GO:0005869; GO:0005874; GO:0010970; GO:0030286; GO:0031122; GO:0090316 0 0 0 PF01302;PF12455; Q6PFY8 CHOYP_BRAFLDRAFT_85511.5.23 m.21481 sp TRI45_MOUSE 32.353 204 118 6 5 196 127 322 2.14E-15 82.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6ZS30 CHOYP_BRAFLDRAFT_83269.1.1 m.1224 sp NBEL1_HUMAN 37.097 248 147 3 4 242 1 248 2.14E-48 174 NBEL1_HUMAN reviewed Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein) NBEAL1 ALS2CR16 ALS2CR17 Homo sapiens (Human) 2694 0 GO:0005543; GO:0012505; GO:0019898 0 0 cd06071; PF02138;PF15787;PF14844;PF00400; Q7YQK3 CHOYP_SLC31.4.5 m.43505 sp 4F2_RABIT 34.043 141 77 4 67 206 61 186 2.14E-19 89 4F2_RABIT reviewed 4F2 cell-surface antigen heavy chain (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98) SLC3A2 Oryctolagus cuniculus (Rabbit) 529 carbohydrate metabolic process [GO:0005975]; leucine import [GO:0060356]; tryptophan transport [GO:0015827] GO:0003824; GO:0005975; GO:0015175; GO:0015827; GO:0016021; GO:0016324; GO:0042470; GO:0060356 0 0 0 PF00128;PF16028; Q8CEF9 CHOYP_LOC656119.1.1 m.55759 sp T132C_MOUSE 24.375 960 604 26 47 944 69 968 2.14E-70 259 T132C_MOUSE reviewed Transmembrane protein 132C Tmem132c Mus musculus (Mouse) 1099 negative regulation of phosphatase activity [GO:0010923] GO:0010923; GO:0016021 0 0 0 PF16070;PF15706;PF15705; Q8IYB9 CHOYP_WDR61.1.2 m.7564 sp ZN595_HUMAN 41.066 319 174 6 156 472 226 532 2.14E-69 236 ZN595_HUMAN reviewed Zinc finger protein 595 ZNF595 Homo sapiens (Human) 648 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q8NCG7 CHOYP_LOC101072367.1.1 m.54105 sp DGLB_HUMAN 39.28 667 374 11 1 654 1 649 2.14E-157 472 DGLB_HUMAN reviewed Sn1-specific diacylglycerol lipase beta (DGL-beta) (EC 3.1.1.-) (KCCR13L) DAGLB Homo sapiens (Human) 672 arachidonic acid metabolic process [GO:0019369]; lipid catabolic process [GO:0016042]; neuroblast proliferation [GO:0007405]; neurotransmitter biosynthetic process [GO:0042136] GO:0005765; GO:0005886; GO:0007405; GO:0016021; GO:0016042; GO:0019369; GO:0042136; GO:0046872; GO:0047372 0 0 0 PF01764; Q91XQ5 CHOYP_LOC100706438.2.2 m.30280 sp CHSTF_MOUSE 31.467 375 213 11 80 414 191 561 2.14E-47 177 CHSTF_MOUSE reviewed Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) Chst15 Brag Galnac4s6st Kiaa0598 Mus musculus (Mouse) 561 hexose biosynthetic process [GO:0019319] GO:0000139; GO:0016021; GO:0019319; GO:0050656; GO:0050659 0 0 0 0 Q96BD8 CHOYP_LOC100368885.1.1 m.7808 sp SKA1_HUMAN 33.696 276 157 5 1 273 1 253 2.14E-43 151 SKA1_HUMAN reviewed Spindle and kinetochore-associated protein 1 SKA1 C18orf24 Homo sapiens (Human) 255 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; regulation of microtubule polymerization or depolymerization [GO:0031110]; sister chromatid cohesion [GO:0007062] GO:0000940; GO:0005829; GO:0005876; GO:0007059; GO:0007062; GO:0007067; GO:0008017; GO:0031110; GO:0051301 0 0 0 PF07160; Q9NUV9 CHOYP_LOC101163984.1.1 m.52437 sp GIMA4_HUMAN 33.762 311 197 3 15 322 21 325 2.14E-54 183 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9R1R2 CHOYP_BRAFLDRAFT_79377.1.30 m.3567 sp TRIM3_MOUSE 23.967 242 152 9 247 476 523 744 2.14E-08 60.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9SZJ2 CHOYP_LOC100367312.5.13 m.31905 sp GRDP2_ARATH 40 285 156 5 5 278 15 295 2.14E-56 208 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; Q9UGM6 CHOYP_LOC100378683.1.1 m.19030 sp SYWM_HUMAN 52.308 325 153 1 39 361 36 360 2.14E-120 355 SYWM_HUMAN reviewed "Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS)" WARS2 Homo sapiens (Human) 360 tRNA aminoacylation for protein translation [GO:0006418]; tryptophanyl-tRNA aminoacylation [GO:0006436]; vasculogenesis [GO:0001570] GO:0001570; GO:0004830; GO:0005524; GO:0005759; GO:0006418; GO:0006436 0 0 0 PF00579; Q9V477 CHOYP_CPIPJ_CPIJ019764.1.1 m.41821 sp TOLL8_DROME 32.278 158 101 2 223 374 1059 1216 2.14E-16 85.9 TOLL8_DROME reviewed Toll-like receptor Tollo (Toll-like receptor 8) Tollo Tl-8 Toll-8 CG6890 Drosophila melanogaster (Fruit fly) 1346 axis elongation [GO:0003401]; convergent extension [GO:0060026]; innate immune response in mucosa [GO:0002227]; peripheral nervous system neuron development [GO:0048935]; regulation of glucose metabolic process [GO:0010906]; regulation of protein glycosylation [GO:0060049]; signal transduction [GO:0007165] GO:0002227; GO:0003401; GO:0007165; GO:0010906; GO:0016021; GO:0016324; GO:0048935; GO:0060026; GO:0060049 0 0 0 PF13306;PF13855;PF01582; A5YM72 CHOYP_CP2CN.1.1 m.20214 sp CRNS1_HUMAN 36.905 84 50 2 19 101 709 790 2.15E-10 59.3 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 D2GXS7 CHOYP_BRAFLDRAFT_87307.1.5 m.32467 sp TRIM2_AILME 22.642 265 180 7 28 279 492 744 2.15E-06 52.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F7B645 CHOYP_BRAFLDRAFT_276659.1.1 m.30213 sp TM231_XENTR 49.164 299 152 0 5 303 1 299 2.15E-107 318 TM231_XENTR reviewed Transmembrane protein 231 tmem231 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 312 cilium assembly [GO:0042384]; smoothened signaling pathway [GO:0007224] GO:0007224; GO:0016021; GO:0035869; GO:0036038; GO:0042384; GO:0060170 0 0 0 PF10149; G5ED84 CHOYP_BACH1.17.17 m.62183 sp KLHL8_CAEEL 27.536 138 92 4 7 137 88 224 2.15E-07 57.4 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O15034 CHOYP_RIMB1.1.5 m.13694 sp RIMB2_HUMAN 37.634 465 237 10 956 1412 167 586 2.15E-75 277 RIMB2_HUMAN reviewed RIMS-binding protein 2 (RIM-BP2) RIMBP2 KIAA0318 RBP2 Homo sapiens (Human) 1052 negative regulation of phosphatase activity [GO:0010923] GO:0005886; GO:0010923; GO:0030054; GO:0045202 0 0 0 PF07653;PF14604; O75030 CHOYP_MITF.2.3 m.25841 sp MITF_HUMAN 60.902 133 46 2 7 133 280 412 2.15E-46 162 MITF_HUMAN reviewed Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) MITF BHLHE32 Homo sapiens (Human) 526 "mast cell migration [GO:0097531]; melanocyte differentiation [GO:0030318]; multicellular organism development [GO:0007275]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein complex assembly [GO:0006461]; protein sumoylation [GO:0016925]; regulation of apoptotic process [GO:0042981]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000122; GO:0000978; GO:0001077; GO:0001227; GO:0005634; GO:0005654; GO:0006355; GO:0006461; GO:0007275; GO:0010628; GO:0016925; GO:0030318; GO:0042981; GO:0043234; GO:0045670; GO:0045893; GO:0045944; GO:0097531; GO:2000144; GO:2001141 0 0 0 PF11851;PF00010;PF15951; O88488 CHOYP_AAEL_AAEL012083.1.1 m.4683 sp PTPRQ_RAT 27.75 1218 716 39 894 2045 1145 2264 2.15E-97 355 PTPRQ_RAT reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1) (rPTP-GMC1) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Ptpgmc1 Rattus norvegicus (Rat) 2302 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0005886; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; O88488 CHOYP_LOC100563606.1.1 m.63821 sp PTPRQ_RAT 25.212 353 186 10 98 389 324 659 2.15E-09 63.5 PTPRQ_RAT reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1) (rPTP-GMC1) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Ptpgmc1 Rattus norvegicus (Rat) 2302 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0005886; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; P02711 CHOYP_ACHD.1.2 m.9195 sp ACHA_TORMA 28 325 215 9 4 318 11 326 2.15E-29 122 ACHA_TORMA reviewed Acetylcholine receptor subunit alpha CHRNA1 Torpedo marmorata (Marbled electric ray) 461 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; P05090 CHOYP_LOC100876114.1.2 m.10757 sp APOD_HUMAN 37.143 175 103 5 18 191 17 185 2.15E-23 95.1 APOD_HUMAN reviewed Apolipoprotein D (Apo-D) (ApoD) APOD Homo sapiens (Human) 189 aging [GO:0007568]; angiogenesis [GO:0001525]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246] GO:0000302; GO:0001525; GO:0005319; GO:0005576; GO:0005615; GO:0005783; GO:0006006; GO:0006629; GO:0007420; GO:0007568; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0042493; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405 0 0 0 PF08212; P08125 CHOYP_SI_RP71-1G18.9.2.2 m.63843 sp COAA1_CHICK 32.407 108 69 3 78 182 563 669 2.15E-09 58.9 COAA1_CHICK reviewed Collagen alpha-1(X) chain COL10A1 Gallus gallus (Chicken) 674 0 GO:0005576; GO:0005578; GO:0005581; GO:0043235 0 0 0 PF00386;PF01391; P10160 CHOYP_EIF5A.2.3 m.22936 sp IF5A1_RABIT 64.557 158 51 2 26 183 1 153 2.15E-70 213 IF5A1_RABIT reviewed Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) EIF5A Oryctolagus cuniculus (Rabbit) 154 mRNA transport [GO:0051028]; positive regulation of translation [GO:0045727]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; protein transport [GO:0015031]; translational frameshifting [GO:0006452] GO:0003746; GO:0005643; GO:0005789; GO:0006452; GO:0015031; GO:0043022; GO:0045727; GO:0045901; GO:0045905; GO:0051028 0 0 0 PF01287; P10280 CHOYP_WFDC8.1.1 m.41463 sp VKT52_ANESU 60 55 22 0 94 148 1 55 2.15E-17 74.3 VKT52_ANESU reviewed KappaPI-actitoxin-Avd3a (KappaPI-AITX-Avd3a) (Kunitz-type proteinase inhibitor 5 II) (SA5 II) 0 Anemonia sulcata (Mediterranean snakelocks sea anemone) 62 0 GO:0004867; GO:0005576; GO:0042151 0 0 0 PF00014; P50429 CHOYP_BRAFLDRAFT_206907.6.11 m.30690 sp ARSB_MOUSE 41.317 501 251 8 20 483 38 532 2.15E-130 391 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; P53442 CHOYP_ALF.3.3 m.66837 sp ALF_SCHMA 73.529 170 45 0 175 344 194 363 2.15E-83 259 ALF_SCHMA reviewed Fructose-bisphosphate aldolase (EC 4.1.2.13) 0 Schistosoma mansoni (Blood fluke) 363 glycolytic process [GO:0006096] GO:0004332; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. 0 0 PF00274; P74148 CHOYP_NEMVEDRAFT_V1G244537.2.3 m.10401 sp Y1388_SYNY3 28.758 153 94 4 15 156 6 154 2.15E-11 61.6 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P84675 CHOYP_THITE_2112326.1.1 m.57511 sp PFM_CHAGB 34.921 189 103 9 30 201 19 204 2.15E-26 103 PFM_CHAGB reviewed Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) 222 defense response to fungus [GO:0050832]; killing of cells of other organism [GO:0031640] GO:0031640; GO:0050832 0 0 0 PF01822; Q03412 CHOYP_LOC100533356.5.6 m.54491 sp UNC7_CAEEL 35.248 383 218 8 64 433 138 503 2.15E-70 234 UNC7_CAEEL reviewed Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans 522 gap junction assembly [GO:0016264]; ion transmembrane transport [GO:0034220]; locomotion [GO:0040011]; oviposition [GO:0018991]; regulation of pharyngeal pumping [GO:0043051]; response to anesthetic [GO:0072347] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0016264; GO:0018991; GO:0032589; GO:0034220; GO:0040011; GO:0043051; GO:0055077; GO:0072347 0 0 0 PF00876; Q10235 CHOYP_BRAFLDRAFT_91528.1.1 m.49327 sp ALP11_SCHPO 36.697 109 65 2 476 584 116 220 2.15E-11 67.8 ALP11_SCHPO reviewed Cell polarity protein alp11 (Altered polarity protein 11) alp11 SPAC13D6.05 SPAC4G9.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 234 cytoplasmic microtubule organization [GO:0031122]; microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005634; GO:0005737; GO:0005829; GO:0005874; GO:0031122 0 0 0 PF01302;PF14560; Q14191 CHOYP_LOC100371899.3.3 m.51662 sp WRN_HUMAN 31.494 308 185 10 42 344 573 859 2.15E-34 141 WRN_HUMAN reviewed "Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)" WRN RECQ3 RECQL2 Homo sapiens (Human) 1432 aging [GO:0007568]; base-excision repair [GO:0006284]; brain development [GO:0007420]; cell aging [GO:0007569]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; multicellular organism aging [GO:0010259]; nucleolus to nucleoplasm transport [GO:0032066]; positive regulation of hydrolase activity [GO:0051345]; protein sumoylation [GO:0016925]; regulation of apoptotic process [GO:0042981]; regulation of growth rate [GO:0040009]; regulation of signal transduction by p53 class mediator [GO:1901796]; replication fork processing [GO:0031297]; replicative cell aging [GO:0001302]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; strand displacement [GO:0000732]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722] GO:0000287; GO:0000403; GO:0000405; GO:0000722; GO:0000723; GO:0000731; GO:0000732; GO:0000784; GO:0001302; GO:0003677; GO:0003678; GO:0003682; GO:0004003; GO:0004386; GO:0004527; GO:0005524; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006302; GO:0006974; GO:0006979; GO:0007420; GO:0007568; GO:0007569; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0010259; GO:0016887; GO:0016925; GO:0030145; GO:0031297; GO:0032066; GO:0032403; GO:0040009; GO:0042803; GO:0042981; GO:0043005; GO:0043138; GO:0043140; GO:0051345; GO:0051880; GO:0071480; GO:1901796 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; Q24524 CHOYP_LOC101061207.1.1 m.48546 sp SING_DROME 31.911 492 306 12 9 490 25 497 2.15E-76 252 SING_DROME reviewed Protein singed sn CG1536 Drosophila melanogaster (Fruit fly) 512 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; cuticle pattern formation [GO:0035017]; dendrite development [GO:0016358]; epidermal cell differentiation [GO:0009913]; establishment or maintenance of cell polarity [GO:0007163]; filopodium assembly [GO:0046847]; hemocyte migration [GO:0035099]; imaginal disc-derived wing hair organization [GO:0035317]; microvillar actin bundle assembly [GO:0030034]; neuron projection morphogenesis [GO:0048812]; oogenesis [GO:0048477]; wound healing [GO:0042060] GO:0003779; GO:0005737; GO:0007015; GO:0007163; GO:0008407; GO:0009913; GO:0015629; GO:0016358; GO:0030034; GO:0030036; GO:0035017; GO:0035099; GO:0035317; GO:0042060; GO:0043005; GO:0043025; GO:0046847; GO:0048477; GO:0048800; GO:0048812; GO:0051015; GO:0051017 0 0 0 PF06268; Q3AF07 CHOYP_GM21_0200.1.1 m.1292 sp DNAJ_CARHZ 53.846 65 30 0 38 102 2 66 2.15E-14 75.5 DNAJ_CARHZ reviewed Chaperone protein DnaJ dnaJ CHY_0416 Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) 381 DNA replication [GO:0006260]; protein folding [GO:0006457]; response to heat [GO:0009408] GO:0005524; GO:0005737; GO:0006260; GO:0006457; GO:0008270; GO:0009408 0 0 cd06257; PF00226;PF01556;PF00684; Q460N5 CHOYP_PAR15.3.6 m.51616 sp PAR14_HUMAN 27.372 548 350 15 4 519 840 1371 2.15E-45 181 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4ZJM9 CHOYP_C1QL2.26.32 m.49778 sp C1QL4_MOUSE 35.374 147 73 8 108 253 108 233 2.15E-10 62.4 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5RJ80 CHOYP_CCD73.2.2 m.57608 sp CAPR2_DANRE 30.827 133 82 4 291 418 784 911 2.15E-09 63.2 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5VZQ5 CHOYP_LOC100377647.1.2 m.10110 sp TEX36_HUMAN 32.692 156 97 3 1 156 1 148 2.15E-13 69.7 TEX36_HUMAN reviewed Testis-expressed sequence 36 protein TEX36 C10orf122 Homo sapiens (Human) 186 0 0 0 0 0 PF15115; Q5ZJ41 CHOYP_MARH5.1.1 m.45222 sp MARH5_CHICK 56.226 265 113 2 13 275 15 278 2.15E-113 331 MARH5_CHICK reviewed E3 ubiquitin-protein ligase MARCH5 (EC 6.3.2.-) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) MARCH5 RCJMB04_20o22 Gallus gallus (Chicken) 281 negative regulation of cell aging [GO:0090344]; positive regulation of mitochondrial fission [GO:0090141]; protein autoubiquitination [GO:0051865]; protein localization to mitochondrion [GO:0070585]; protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140] GO:0000209; GO:0004842; GO:0005741; GO:0005783; GO:0005789; GO:0008270; GO:0016021; GO:0016874; GO:0051865; GO:0070585; GO:0090140; GO:0090141; GO:0090344 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q641M3 CHOYP_ANR31.1.1 m.61076 sp TMM18_DANRE 36.552 145 91 1 2 146 9 152 2.15E-29 107 TMM18_DANRE reviewed Transmembrane protein 18 tmem18 zgc:101011 Danio rerio (Zebrafish) (Brachydanio rerio) 152 0 GO:0003677; GO:0016021; GO:0031965 0 0 0 PF14770; Q6AYQ8 CHOYP_LOC581398.1.2 m.3516 sp FAHD1_RAT 54.023 174 79 1 1 173 1 174 2.15E-71 217 FAHD1_RAT reviewed "Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.3)" Fahd1 Rattus norvegicus (Rat) 221 metabolic process [GO:0008152] GO:0005654; GO:0005739; GO:0005743; GO:0005829; GO:0008152; GO:0008948; GO:0018773; GO:0034545; GO:0046872; GO:0047621 0 0 0 PF01557; Q6DG03 CHOYP_DMTF1.2.2 m.19572 sp DMTF1_DANRE 49.21 443 169 9 469 860 111 548 2.15E-129 409 DMTF1_DANRE reviewed Cyclin-D-binding Myb-like transcription factor 1 dmtf1 si:dkey-153k10.8 zgc:92448 Danio rerio (Zebrafish) (Brachydanio rerio) 645 "cell cycle [GO:0007049]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007049 0 0 0 PF00249; Q6GNV7 CHOYP_BRAFLDRAFT_123718.2.2 m.63385 sp DIRC2_XENLA 33.261 463 275 5 20 478 24 456 2.15E-78 255 DIRC2_XENLA reviewed Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) 456 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6PEH1 CHOYP_ERD22.1.1 m.12383 sp ERD22_DANRE 82.09 201 36 0 1 201 1 201 2.15E-123 351 ERD22_DANRE reviewed ER lumen protein-retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) kdelr2 Danio rerio (Zebrafish) (Brachydanio rerio) 212 protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0006621; GO:0015031; GO:0016021; GO:0016192; GO:0046923 0 0 0 PF00810; Q6R5N8 CHOYP_TLR7.1.2 m.23610 sp TLR13_MOUSE 24.959 613 357 21 130 694 420 977 2.15E-34 144 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q80V94 CHOYP_LOC101074794.1.1 m.64888 sp AP4E1_MOUSE 32.065 368 244 2 2 367 197 560 2.15E-58 208 AP4E1_MOUSE reviewed AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) Ap4e1 Mus musculus (Mouse) 1122 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005802; GO:0005905; GO:0006886; GO:0016192; GO:0030117 0 0 0 PF01602;PF14807; Q80ZI6 CHOYP_LOC100369519.1.1 m.56988 sp LRSM1_MOUSE 37.584 745 422 12 53 776 1 723 2.15E-134 419 LRSM1_MOUSE reviewed E3 ubiquitin-protein ligase LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) Lrsam1 Mus musculus (Mouse) 727 autophagy [GO:0006914]; negative regulation of endocytosis [GO:0045806]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of xenophagy [GO:1904417]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent endocytosis [GO:0070086]; viral budding [GO:0046755] GO:0000209; GO:0004842; GO:0005737; GO:0006914; GO:0008270; GO:0016020; GO:0016874; GO:0030163; GO:0045806; GO:0046755; GO:0051865; GO:0061630; GO:0070086; GO:1904417; GO:2000786 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6UWE0}. 0 0 PF13855;PF00536; Q8C6K9 CHOYP_BRAFLDRAFT_90332.3.4 m.18933 sp CO6A6_MOUSE 26.601 609 395 14 24 625 615 1178 2.15E-56 210 CO6A6_MOUSE reviewed Collagen alpha-6(VI) chain Col6a6 Mus musculus (Mouse) 2265 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; Q8HY12 CHOYP_LOC100656236.1.1 m.27240 sp CLC4M_HYLLA 29.054 148 85 4 21 166 267 396 2.15E-15 75.9 CLC4M_HYLLA reviewed C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (CD antigen CD299) CLEC4M CD209L1 Hylobates lar (Common gibbon) (White-handed gibbon) 399 adaptive immune response [GO:0002250]; endocytosis [GO:0006897]; innate immune response [GO:0045087] GO:0002250; GO:0005537; GO:0006897; GO:0016021; GO:0045087; GO:0046872 0 0 0 PF00059; Q8IDX6 CHOYP_TBB4B.4.7 m.39102 sp RBP2A_PLAF7 33.945 109 72 0 316 424 2755 2863 2.15E-15 83.6 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8IYS1 CHOYP_P20D2.2.2 m.47191 sp P20D2_HUMAN 51.861 403 183 4 1 392 20 422 2.15E-139 407 P20D2_HUMAN reviewed Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) PM20D2 ACY1L2 Homo sapiens (Human) 436 proteolysis [GO:0006508]; regulation of cellular protein metabolic process [GO:0032268] GO:0005654; GO:0006508; GO:0016805; GO:0032268; GO:0070062 0 0 0 PF07687;PF01546; Q91DM0 CHOYP_CBG17454.2.2 m.66257 sp POLG_PVCV1 28.481 158 109 2 284 441 1436 1589 2.15E-10 67 POLG_PVCV1 reviewed Genome polyprotein [Cleaved into: Movement protein (MP); Capsid protein (CP); Aspartic protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49)] 0 Petunia vein clearing virus (isolate Shepherd) (PVCV) 2179 "transport of virus in host, cell to cell [GO:0046740]" GO:0003677; GO:0003964; GO:0004190; GO:0004519; GO:0008270; GO:0046740 0 0 0 PF01107;PF00078;PF00098; Q96MM6 CHOYP_BRAFLDRAFT_208197.13.21 m.50507 sp HS12B_HUMAN 33.908 348 167 9 26 322 61 396 2.15E-53 189 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96RW7 CHOYP_NEMVEDRAFT_V1G88031.5.5 m.58705 sp HMCN1_HUMAN 41.667 96 45 5 93 184 4546 4634 2.15E-12 68.9 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99618 CHOYP_CDCA3.1.1 m.12906 sp CDCA3_HUMAN 40 75 30 1 15 74 10 84 2.15E-06 50.8 CDCA3_HUMAN reviewed Cell division cycle-associated protein 3 (Gene-rich cluster protein C8) (Trigger of mitotic entry protein 1) (TOME-1) CDCA3 C8 GRCC8 TOME1 Homo sapiens (Human) 268 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0005829; GO:0005911; GO:0007067; GO:0016567; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q9D1H8 CHOYP_LOC663488.1.1 m.18582 sp RM53_MOUSE 29.032 93 66 0 14 106 5 97 2.15E-09 54.7 RM53_MOUSE reviewed "39S ribosomal protein L53, mitochondrial (L53mt) (MRP-L53)" Mrpl53 Mus musculus (Mouse) 118 0 GO:0005739; GO:0005840 0 0 0 PF10780; Q9EPH8 CHOYP_PABP4.5.6 m.38922 sp PABP1_RAT 59.563 183 69 2 1 182 208 386 2.15E-63 209 PABP1_RAT reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Rattus norvegicus (Rat) 636 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0003729; GO:0005681; GO:0006397; GO:0008143; GO:0008380; GO:0010494; GO:0030425; GO:0030529; GO:0031047; GO:0060213; GO:1900153; GO:1990124; GO:2000623 0 0 0 PF00658;PF00076; Q9ESN6 CHOYP_LOC100369186.4.9 m.42344 sp TRIM2_MOUSE 26.19 210 133 7 283 483 536 732 2.15E-07 57.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H0F5 CHOYP_RF12A.1.1 m.38412 sp RNF38_HUMAN 46.591 88 44 1 742 826 419 506 2.15E-21 102 RNF38_HUMAN reviewed E3 ubiquitin-protein ligase RNF38 (EC 6.3.2.-) (RING finger protein 38) RNF38 Homo sapiens (Human) 515 "male gonad development [GO:0008584]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]" GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0008270; GO:0008584; GO:0016567; GO:0016874; GO:0036126; GO:0043161; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q9JKQ2 CHOYP_LOC100552593.2.3 m.57380 sp S26A5_MERUN 37.003 754 415 12 68 793 10 731 2.15E-162 492 S26A5_MERUN reviewed Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) 744 regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605] GO:0007605; GO:0008271; GO:0008360; GO:0016021; GO:0016323 0 0 0 PF01740;PF00916; Q9NWW9 CHOYP_contig_049792 m.59157 sp HRSL2_HUMAN 31.655 139 70 6 122 254 11 130 2.15E-06 50.4 HRSL2_HUMAN reviewed HRAS-like suppressor 2 (EC 2.3.1.-) (EC 3.1.1.-) HRASLS2 Homo sapiens (Human) 162 lipid catabolic process [GO:0016042] GO:0005737; GO:0016021; GO:0016042; GO:0016746; GO:0016787 0 0 0 PF04970; Q9W2N0 CHOYP_LOC552486.1.1 m.44562 sp CAPZA_DROME 62.63 289 99 2 7 295 5 284 2.15E-137 392 CAPZA_DROME reviewed F-actin-capping protein subunit alpha cpa CG10540 Drosophila melanogaster (Fruit fly) 286 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; germarium-derived oocyte fate determination [GO:0007294]; microtubule-based movement [GO:0007018]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of JNK cascade [GO:0046329]; phagocytosis [GO:0006909]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]; sensory perception of pain [GO:0019233]; wing disc development [GO:0035220] GO:0000902; GO:0005869; GO:0005875; GO:0006909; GO:0007015; GO:0007018; GO:0007294; GO:0008290; GO:0010591; GO:0016324; GO:0019233; GO:0030036; GO:0030837; GO:0035220; GO:0046329; GO:0046982; GO:0051016; GO:0051489; GO:0051490 0 0 0 PF01267; Q9Y6G5 CHOYP_MET14.1.1 m.5074 sp COMDA_HUMAN 53.158 190 89 0 8 197 12 201 2.15E-61 192 COMDA_HUMAN reviewed COMM domain-containing protein 10 COMMD10 HSPC305 PTD002 Homo sapiens (Human) 202 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355 0 0 0 PF07258; A1E295 CHOYP_NEMVEDRAFT_V1G191860.1.1 m.41327 sp CATB_PIG 46.154 65 28 2 17 81 14 71 2.16E-12 64.7 CATB_PIG reviewed Cathepsin B (EC 3.4.22.1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB Sus scrofa (Pig) 335 cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of catalytic activity [GO:0050790]; viral entry into host cell [GO:0046718] GO:0004197; GO:0005615; GO:0005730; GO:0005739; GO:0005764; GO:0030574; GO:0030855; GO:0042470; GO:0043394; GO:0046697; GO:0046718; GO:0048471; GO:0050790; GO:0051603; GO:0070062; GO:0097067 0 0 0 PF00112;PF08127; A1L1R5 CHOYP_LOC100890521.1.1 m.55845 sp PTPC1_DANRE 49.258 337 154 4 24 359 24 344 2.16E-115 363 PTPC1_DANRE reviewed Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-) ptpdc1 zgc:158271 Danio rerio (Zebrafish) (Brachydanio rerio) 713 cilium morphogenesis [GO:0060271] GO:0004725; GO:0005634; GO:0005737; GO:0008138; GO:0060271 0 0 0 PF00782; A1L259 CHOYP_BRAFLDRAFT_276474.1.1 m.6793 sp URAD_DANRE 53.216 171 80 0 6 176 1 171 2.16E-58 183 URAD_DANRE reviewed 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) (EC 4.1.1.97) (Parahox neighbor) (Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase) urad prhoxnb zgc:158663 Danio rerio (Zebrafish) (Brachydanio rerio) 174 allantoin biosynthetic process [GO:0019428]; purine nucleobase metabolic process [GO:0006144]; urate catabolic process [GO:0019628] GO:0005777; GO:0006144; GO:0016831; GO:0019428; GO:0019628 PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3. 0 0 PF09349; A5YM72 CHOYP_CARNS1.3.6 m.15058 sp CRNS1_HUMAN 40 105 57 1 35 133 310 414 2.16E-16 79.3 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 O95236 CHOYP_FBXO30.1.1 m.48441 sp APOL3_HUMAN 25.941 239 168 2 21 250 148 386 2.16E-14 75.5 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P01266 CHOYP_contig_056232 m.66802 sp THYG_HUMAN 45.652 46 25 0 1 46 1465 1510 2.16E-06 49.3 THYG_HUMAN reviewed Thyroglobulin (Tg) TG Homo sapiens (Human) 2768 hormone biosynthetic process [GO:0042446]; iodide transport [GO:0015705]; regulation of myelination [GO:0031641]; response to lipopolysaccharide [GO:0032496]; response to pH [GO:0009268]; signal transduction [GO:0007165]; thyroid gland development [GO:0030878]; thyroid hormone generation [GO:0006590]; transcytosis [GO:0045056] GO:0005576; GO:0005615; GO:0005783; GO:0005794; GO:0006590; GO:0007165; GO:0009268; GO:0015705; GO:0030878; GO:0031641; GO:0032496; GO:0042446; GO:0043168; GO:0043234; GO:0045056; GO:0048471; GO:0052689 0 0 0 PF00135;PF07699;PF00086; P06782 CHOYP_BRAFLDRAFT_271463.1.1 m.62870 sp SNF1_YEAST 31.364 220 123 4 255 462 43 246 2.16E-20 99 SNF1_YEAST reviewed Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) SNF1 CAT1 CCR1 GLC2 PAS14 YDR477W D8035.20 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 633 carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; cellular response to nitrogen starvation [GO:0006995]; fungal-type cell wall assembly [GO:0071940]; intracellular signal transduction [GO:0035556]; invasive growth in response to glucose limitation [GO:0001403]; negative regulation of translation [GO:0017148]; positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [GO:1900436]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of macroautophagy [GO:0016239]; protein phosphorylation [GO:0006468]; pseudohyphal growth [GO:0007124]; replicative cell aging [GO:0001302]; response to unfolded protein [GO:0006986]; single-species surface biofilm formation [GO:0090606] GO:0000324; GO:0001302; GO:0001403; GO:0004674; GO:0004679; GO:0005086; GO:0005524; GO:0005634; GO:0005641; GO:0005737; GO:0005975; GO:0006468; GO:0006986; GO:0006995; GO:0007124; GO:0007155; GO:0016239; GO:0017148; GO:0031588; GO:0031965; GO:0035556; GO:0045722; GO:0071940; GO:0090606; GO:1900436 0 0 cd14334; PF16579;PF00069;PF08587; P09118 CHOYP_URIC.2.2 m.54754 sp URIC_RAT 51.525 295 139 1 8 302 13 303 2.16E-108 320 URIC_RAT reviewed Uricase (EC 1.7.3.3) (Urate oxidase) Uox Rattus norvegicus (Rat) 303 allantoin biosynthetic process [GO:0019428]; purine nucleobase catabolic process [GO:0006145]; urate catabolic process [GO:0019628] GO:0004846; GO:0005739; GO:0005777; GO:0005782; GO:0006145; GO:0019428; GO:0019628 PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. 0 0 PF01014; P0C1H5 CHOYP_H2BL3.1.1 m.16594 sp H2B7_CHICK 83.193 119 19 1 27 145 8 125 2.16E-66 200 H2B7_CHICK reviewed Histone H2B 7 (H2B VII) H2B-VII Gallus gallus (Chicken) 126 nucleosome assembly [GO:0006334] GO:0000788; GO:0003677; GO:0005811; GO:0006334 0 0 0 PF00125; P16157 CHOYP_LOC100635111.5.13 m.21472 sp ANK1_HUMAN 35.278 360 233 0 1 360 230 589 2.16E-61 216 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20480 CHOYP_CTK2.3.3 m.51999 sp NCD_DROME 39.48 423 210 13 216 620 273 667 2.16E-75 258 NCD_DROME reviewed Protein claret segregational ncd CA(ND) CG7831 Drosophila melanogaster (Fruit fly) 700 cell division [GO:0051301]; centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; chromosome segregation [GO:0007059]; distributive segregation [GO:0032837]; meiotic spindle organization [GO:0000212]; microtubule-based movement [GO:0007018]; microtubule bundle formation [GO:0001578]; minus-end directed microtubule sliding [GO:0031534]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; regulation of mitotic spindle assembly [GO:1901673]; regulation of mitotic spindle elongation [GO:0032888]; spindle assembly involved in female meiosis [GO:0007056]; spindle assembly involved in meiosis [GO:0090306]; spindle organization [GO:0007051] GO:0000022; GO:0000212; GO:0001578; GO:0003777; GO:0005524; GO:0005634; GO:0005813; GO:0005819; GO:0005829; GO:0005871; GO:0007018; GO:0007051; GO:0007052; GO:0007056; GO:0007059; GO:0007100; GO:0008569; GO:0016887; GO:0031534; GO:0032837; GO:0032888; GO:0042803; GO:0051028; GO:0051297; GO:0051298; GO:0051301; GO:0072687; GO:0090306; GO:0090307; GO:1901673; GO:1990498 0 0 0 PF00225; P22105 CHOYP_NAEGRDRAFT_73289.1.1 m.13171 sp TENX_HUMAN 38.372 86 43 6 90 174 266 342 2.16E-06 52.4 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P27473 CHOYP_LOC100377780.10.11 m.57494 sp IFI44_PANTR 33.103 145 89 3 258 395 168 311 2.16E-16 84.3 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P30280 CHOYP_CCND.1.1 m.52597 sp CCND2_MOUSE 59.322 295 106 3 1 289 1 287 2.16E-115 337 CCND2_MOUSE reviewed G1/S-specific cyclin-D2 Ccnd2 Cyl-2 Mus musculus (Mouse) 289 cell cycle [GO:0007049]; cell division [GO:0051301]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of protein phosphorylation [GO:0001934]; regulation of cell cycle [GO:0051726] GO:0000307; GO:0000785; GO:0001934; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0007049; GO:0019901; GO:0031965; GO:0045737; GO:0051301; GO:0051726; GO:0097129 0 0 0 PF02984;PF00134; P31331 CHOYP_LOC100378901.1.2 m.29418 sp GLB_NASMU 28.671 143 101 1 13 154 1 143 2.16E-16 74.7 GLB_NASMU reviewed Globin (Myoglobin) 0 Nassarius mutabilis (Sea snail) (Buccinum mutabile) 147 0 GO:0005344; GO:0005506; GO:0005576; GO:0005833; GO:0019825; GO:0020037 0 0 0 PF00042; P37892 CHOYP_CPE.1.1 m.53041 sp CBPE_LOPAM 48.423 444 206 12 1 438 1 427 2.16E-135 402 CBPE_LOPAM reviewed Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase) cpe Lophius americanus (American angler) (Anglerfish) 454 0 GO:0004181; GO:0005576; GO:0008270; GO:0030658 0 0 0 PF00246; P46791 CHOYP_BRAFLDRAFT_275374.1.3 m.17727 sp RS2_CRIGR 90 110 11 0 5 114 86 195 2.16E-69 209 RS2_CRIGR reviewed 40S ribosomal protein S2 (Fragment) RPS2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 202 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; P51449 CHOYP_RORG.1.2 m.3285 sp RORG_HUMAN 28.656 506 309 20 36 513 26 507 2.16E-32 133 RORG_HUMAN reviewed Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) RORC NR1F3 RORG RZRG Homo sapiens (Human) 518 "adipose tissue development [GO:0060612]; cellular response to sterol [GO:0036315]; circadian regulation of gene expression [GO:0032922]; lymph node development [GO:0048535]; negative regulation of thymocyte apoptotic process [GO:0070244]; Peyer's patch development [GO:0048541]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; regulation of glucose metabolic process [GO:0010906]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription involved in cell fate commitment [GO:0060850]; T-helper 17 cell differentiation [GO:0072539]; T-helper cell differentiation [GO:0042093]; transcription initiation from RNA polymerase II promoter [GO:0006367]; xenobiotic metabolic process [GO:0006805]" GO:0003677; GO:0003700; GO:0003707; GO:0004879; GO:0005634; GO:0005654; GO:0005730; GO:0006367; GO:0006805; GO:0008142; GO:0008270; GO:0010906; GO:0019218; GO:0032922; GO:0036315; GO:0042093; GO:0042753; GO:0043231; GO:0043565; GO:0045598; GO:0045893; GO:0048535; GO:0048541; GO:0060612; GO:0060850; GO:0070244; GO:0072539; GO:0098531 0 0 0 PF00104;PF00105; P82930 CHOYP_LOC100877992.1.1 m.1507 sp RT34_HUMAN 31.69 142 77 6 27 156 77 210 2.16E-07 52 RT34_HUMAN reviewed "28S ribosomal protein S34, mitochondrial (MRP-S34) (S34mt)" MRPS34 Homo sapiens (Human) 218 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126] GO:0003735; GO:0005739; GO:0005743; GO:0005840; GO:0032543; GO:0070125; GO:0070126 0 0 0 PF16053; P86862 CHOYP_BRAFLDRAFT_163244.2.3 m.28408 sp VKT1_ANTEL 57.143 56 24 0 91 146 2 57 2.16E-18 77 VKT1_ANTEL reviewed KappaPI-actitoxin-Ael3a (KappaPI-AITX-Ael3a) (Kunitz-type serine protease inhibitor APEKTx1) 0 Anthopleura elegantissima (Sea anemone) 65 0 GO:0004867; GO:0005576; GO:0019870; GO:0042151 0 0 0 PF00014; Q02357 CHOYP_AFUA_1G01020.9.50 m.21389 sp ANK1_MOUSE 41.089 202 119 0 1 202 226 427 2.16E-37 141 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q1JPJ2 CHOYP_TRIADDRAFT_64367.1.1 m.42126 sp XPP1_BOVIN 42.302 643 337 14 71 706 6 621 2.16E-163 488 XPP1_BOVIN reviewed "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 Bos taurus (Bovine) 623 bradykinin catabolic process [GO:0010815] GO:0005737; GO:0010815; GO:0030145; GO:0070006; GO:0070062 0 0 0 PF01321;PF00557;PF16188; Q2QI47 CHOYP_LOC100913523.1.1 m.33813 sp USH2A_MOUSE 20.73 767 462 30 34 754 4074 4740 2.16E-12 75.1 USH2A_MOUSE reviewed Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) 5193 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042803; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF00054;PF02210;PF00055; Q3UVV9 CHOYP_LOC100372388.1.1 m.26623 sp VWA3A_MOUSE 36.257 171 104 2 9 177 909 1076 2.16E-20 101 VWA3A_MOUSE reviewed von Willebrand factor A domain-containing protein 3A Vwa3a Mus musculus (Mouse) 1148 0 0 0 0 0 PF13768; Q502K3 CHOYP_Y045.1.1 m.43767 sp ANR52_DANRE 32.653 147 99 0 38 184 133 279 2.16E-15 79.7 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q58DA6 CHOYP_LOC100703978.1.1 m.11603 sp S35A2_BOVIN 54.192 334 145 3 2 328 7 339 2.16E-114 340 S35A2_BOVIN reviewed UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT) SLC35A2 Bos taurus (Bovine) 393 0 GO:0000139; GO:0005351; GO:0016021 0 0 0 PF04142; Q5BIM1 CHOYP_PHUM_PHUM463540.1.1 m.13401 sp TRI45_BOVIN 24.675 231 141 10 5 211 129 350 2.16E-06 53.5 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5ND28 CHOYP_MEG10.63.91 m.50476 sp SREC_MOUSE 29.965 287 157 12 146 407 212 479 2.16E-21 100 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5XI63 CHOYP_CTK2.1.3 m.41053 sp KIFC1_RAT 36.517 356 172 11 217 531 256 598 2.16E-54 198 KIFC1_RAT reviewed Kinesin-like protein KIFC1 (Kinesin-related protein 1) Kifc1 Krp1 Rattus norvegicus (Rat) 693 cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; spermatogenesis [GO:0007283] GO:0003777; GO:0005524; GO:0005634; GO:0005769; GO:0005815; GO:0005819; GO:0005871; GO:0005874; GO:0007018; GO:0007080; GO:0007283; GO:0016020; GO:0016887; GO:0051301; GO:0090307 0 0 0 PF00225; Q68F99 CHOYP_DPSE_GA30479.1.1 m.52439 sp STAC3_XENTR 41.88 117 67 1 270 386 222 337 2.16E-25 108 STAC3_XENTR reviewed SH3 and cysteine-rich domain-containing protein 3 stac3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 337 intracellular signal transduction [GO:0035556]; neuromuscular synaptic transmission [GO:0007274]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue development [GO:0007519] GO:0003009; GO:0005622; GO:0007274; GO:0007519; GO:0035556; GO:0046872 0 0 0 PF00130;PF07653;PF14604; Q6AY62 CHOYP_NEUFC.1.1 m.44515 sp NEUFC_RAT 42.918 233 127 3 51 277 31 263 2.16E-70 221 NEUFC_RAT reviewed Neuferricin (Cytochrome b5 domain-containing protein 2) Cyb5d2 Rattus norvegicus (Rat) 263 positive regulation of neuron differentiation [GO:0045666] GO:0005576; GO:0012505; GO:0016020; GO:0020037; GO:0045666 0 0 0 PF00173; Q6AYN9 CHOYP_BRAFLDRAFT_132233.3.4 m.20066 sp CC181_RAT 26.72 378 213 11 111 440 143 504 2.16E-19 94 CC181_RAT reviewed Coiled-coil domain-containing protein 181 Ccdc181 Rattus norvegicus (Rat) 509 0 GO:0005654 0 0 0 0 Q6PDJ1 CHOYP_NEMVEDRAFT_V1G239644.2.4 m.40606 sp CAHD1_MOUSE 27.176 850 530 29 26 815 59 879 2.16E-74 268 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q7T3N8 CHOYP_LOC100745778.1.1 m.27697 sp RL15_CTEID 75.49 204 50 0 1 204 1 204 2.16E-114 327 RL15_CTEID reviewed 60S ribosomal protein L15 rpl15 Ctenopharyngodon idella (Grass carp) (Leuciscus idella) 204 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00827; Q8IY33 CHOYP_LOC100372213.1.1 m.61444 sp MILK2_HUMAN 44.954 218 90 1 5 192 4 221 2.16E-59 223 MILK2_HUMAN reviewed MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) MICALL2 JRAB Homo sapiens (Human) 904 actin cytoskeleton reorganization [GO:0031532]; actin filament polymerization [GO:0030041]; bicellular tight junction assembly [GO:0070830]; endocytic recycling [GO:0032456]; neuron projection development [GO:0031175]; positive regulation of protein targeting to mitochondrion [GO:1903955]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0001725; GO:0005829; GO:0005886; GO:0005911; GO:0005923; GO:0008270; GO:0030041; GO:0031005; GO:0031175; GO:0031532; GO:0032456; GO:0034446; GO:0043005; GO:0051015; GO:0055037; GO:0070830; GO:1903955 0 0 0 PF00307;PF12130;PF00412; Q8N859 CHOYP_LOC581084.1.1 m.6938 sp ZN713_HUMAN 48.171 164 78 2 277 438 253 411 2.16E-44 164 ZN713_HUMAN reviewed Zinc finger protein 713 ZNF713 Homo sapiens (Human) 430 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q96DM1 CHOYP_LOC100498109.1.3 m.29964 sp PGBD4_HUMAN 26.136 176 123 3 159 328 100 274 2.16E-17 86.7 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q96RW7 CHOYP_HMCN2.4.12 m.28980 sp HMCN1_HUMAN 26.385 1588 973 64 306 1839 468 1913 2.16E-98 360 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96RW7 CHOYP_contig_047807 m.56474 sp HMCN1_HUMAN 24.566 346 209 14 259 584 941 1254 2.16E-10 69.3 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9C040 CHOYP_TRIM2.49.59 m.54966 sp TRIM2_HUMAN 30.455 220 133 6 325 533 533 743 2.16E-15 82.8 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H1A4 CHOYP_APC1.2.3 m.5976 sp APC1_HUMAN 74.419 215 53 1 1 213 1094 1308 2.16E-104 335 APC1_HUMAN reviewed Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein) ANAPC1 TSG24 Homo sapiens (Human) 1944 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005654; GO:0005680; GO:0005829; GO:0007067; GO:0031145; GO:0042787; GO:0043161; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12859; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G247395.7.8 m.47406 sp SACS_HUMAN 23.322 596 363 20 11 540 4005 4572 2.16E-21 102 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9VCA8 CHOYP_LOC100640442.9.10 m.64063 sp ANKHM_DROME 39.921 253 136 9 686 923 543 794 2.16E-32 140 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9XT77 CHOYP_LOC582008.2.3 m.53880 sp SC5A6_RABIT 35.275 601 360 12 5 599 23 600 2.16E-106 337 SC5A6_RABIT reviewed Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (Solute carrier family 5 member 6) SLC5A6 SMVT Oryctolagus cuniculus (Rabbit) 636 sodium ion transport [GO:0006814] GO:0006814; GO:0015293; GO:0016021 0 0 0 PF00474; A8WHP3 CHOYP_SC5A9.4.5 m.45146 sp SC5A9_DANRE 42.941 340 184 2 3 337 321 655 2.17E-99 310 SC5A9_DANRE reviewed Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (Solute carrier family 5 member 9) slc5a9 si:dkey-7o6.5 Danio rerio (Zebrafish) (Brachydanio rerio) 657 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293 0 0 0 PF00474; D3ZV31 CHOYP_ZCCHC4.1.1 m.14416 sp ZCHC4_RAT 47.149 456 233 6 21 469 27 481 2.17E-146 430 ZCHC4_RAT reviewed Zinc finger CCHC domain-containing protein 4 Zcchc4 Rattus norvegicus (Rat) 489 0 GO:0003676; GO:0008168; GO:0008270; GO:0016746 0 0 0 PF10237;PF06839; D8VNS7 CHOYP_LOC100638270.1.1 m.19942 sp FCNV1_CERRY 48.677 189 87 4 300 487 128 307 2.17E-48 173 FCNV1_CERRY reviewed Ryncolin-1 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; O14095 CHOYP_LOC585158.2.2 m.19195 sp PLP1_SCHPO 42.857 168 93 2 14 180 112 277 2.17E-39 138 PLP1_SCHPO reviewed Thioredoxin domain-containing protein plp1 (Phosducin-like protein 1) plp1 SPAC2F3.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 279 cell redox homeostasis [GO:0045454]; negative regulation of signal transduction [GO:0009968]; queuosine biosynthetic process [GO:0008616]; response to pheromone [GO:0019236] GO:0005634; GO:0005737; GO:0005829; GO:0008616; GO:0009968; GO:0019236; GO:0045454 0 0 0 PF00085; O42350 CHOYP_contig_027593 m.31285 sp CO1A2_LITCT 43.765 1291 637 20 175 1417 106 1355 2.17E-148 490 CO1A2_LITCT reviewed Collagen alpha-2(I) chain (Alpha-2 type I collagen) COL1A2 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 1355 0 GO:0005201; GO:0005578; GO:0005581; GO:0046872 0 0 0 PF01410;PF01391; O42409 CHOYP_GFI1B.1.1 m.36093 sp GFI1B_CHICK 52.059 340 144 8 20 344 1 336 2.17E-103 310 GFI1B_CHICK reviewed Zinc finger protein Gfi-1b (Growth factor-independent protein 1B) GFI1B GFI Gallus gallus (Chicken) 337 "covalent chromatin modification [GO:0016569]; hemopoiesis [GO:0030097]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005667; GO:0006351; GO:0006355; GO:0016363; GO:0016569; GO:0030097; GO:0046872; GO:0051569 0 0 0 PF00096; O43399 CHOYP_AGAP_AGAP004868.1.1 m.60336 sp TPD54_HUMAN 39.506 162 85 2 50 211 55 203 2.17E-32 119 TPD54_HUMAN reviewed Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) 206 regulation of cell proliferation [GO:0042127] GO:0005737; GO:0042127; GO:0042803; GO:0044822; GO:0046982; GO:0048471 0 0 0 PF04201; O61122 CHOYP_LOC100121999.3.4 m.54805 sp SVKA_DICDI 63.91 266 95 1 17 281 16 281 2.17E-125 378 SVKA_DICDI reviewed Serine/threonine-protein kinase svkA (EC 2.7.11.1) (Severin kinase A) svkA DDB_G0286359 Dictyostelium discoideum (Slime mold) 478 cell division [GO:0051301]; hippo signaling [GO:0035329]; hyperosmotic response [GO:0006972]; mitotic cell cycle [GO:0000278]; positive regulation of cell division [GO:0051781]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell separation after cytokinesis [GO:0010590]; regulation of sorocarp development [GO:0031156] GO:0000278; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0006468; GO:0006972; GO:0010590; GO:0015629; GO:0031156; GO:0032154; GO:0032956; GO:0035329; GO:0046777; GO:0046872; GO:0051301; GO:0051781 0 0 0 PF00069; P05945 CHOYP_MLE.8.9 m.48876 sp MLE_TODPA 58.784 148 59 2 15 161 8 154 2.17E-56 177 MLE_TODPA reviewed "Myosin catalytic light chain LC-1, mantle muscle" 0 Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) 160 0 GO:0005509; GO:0016459 0 0 0 PF13405; P14381 CHOYP_LIN1.3.3 m.36771 sp YTX2_XENLA 29.31 464 313 9 1 460 437 889 2.17E-54 199 YTX2_XENLA reviewed Transposon TX1 uncharacterized 149 kDa protein (ORF 2) 0 Xenopus laevis (African clawed frog) 1308 0 0 0 0 0 PF03372;PF00078; P18715 CHOYP_CPIPJ_CPIJ016789.1.1 m.24767 sp ZG26_XENLA 43.694 222 117 6 10 228 117 333 2.17E-40 151 ZG26_XENLA reviewed Gastrula zinc finger protein XlCGF26.1 (Fragment) 0 Xenopus laevis (African clawed frog) 337 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; P29341 CHOYP_LOC100370010.3.5 m.19117 sp PABP1_MOUSE 87.719 171 21 0 6 176 1 171 2.17E-111 333 PABP1_MOUSE reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Mus musculus (Mouse) 636 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0003729; GO:0005634; GO:0005737; GO:0005925; GO:0006397; GO:0008022; GO:0008143; GO:0008266; GO:0008380; GO:0010494; GO:0016020; GO:0030425; GO:0030529; GO:0031047; GO:0036464; GO:0044822; GO:0045070; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:1990124; GO:2000623 0 0 0 PF00658;PF00076; P42674 CHOYP_LOC100201155.1.1 m.58066 sp BP10_PARLI 28.652 356 211 14 140 468 97 436 2.17E-27 121 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P50882 CHOYP_RL9.3.6 m.33415 sp RL9_DROME 67.544 114 35 2 17 128 73 186 2.17E-46 151 RL9_DROME reviewed 60S ribosomal protein L9 RpL9 M(2)32D CG6141 Drosophila melanogaster (Fruit fly) 190 centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052] GO:0000022; GO:0002181; GO:0003723; GO:0003735; GO:0005840; GO:0007052; GO:0019843; GO:0022625; GO:0051298 0 0 0 PF00347; P52632 CHOYP_LOC101065277.1.1 m.52776 sp STA5B_RAT 22.56 625 357 26 110 671 94 654 2.17E-18 94.7 STA5B_RAT reviewed Signal transducer and activator of transcription 5B Stat5b Rattus norvegicus (Rat) 786 "acute-phase response [GO:0006953]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; JAK-STAT cascade [GO:0007259]; liver development [GO:0001889]; luteinization [GO:0001553]; positive regulation of cellular component movement [GO:0051272]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; prolactin signaling pathway [GO:0038161]; regulation of transcription, DNA-templated [GO:0006355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to peptide hormone [GO:0043434]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0001553; GO:0001666; GO:0001889; GO:0003677; GO:0003682; GO:0003690; GO:0003700; GO:0004871; GO:0005634; GO:0005737; GO:0005829; GO:0006355; GO:0006366; GO:0006953; GO:0007259; GO:0032496; GO:0038161; GO:0043434; GO:0043565; GO:0045471; GO:0045648; GO:0045944; GO:0046983; GO:0048661; GO:0051272; GO:0071363; GO:0071364 0 0 0 PF00017;PF01017;PF02864;PF02865; P86789 CHOYP_LOC100375482.2.2 m.49067 sp GIGA6_CRAGI 30.047 213 145 4 5 214 65 276 2.17E-25 108 GIGA6_CRAGI reviewed Gigasin-6 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 302 0 GO:0016021 0 0 0 PF00144; P97353 CHOYP_FUT2.5.5 m.63708 sp SEC1_MOUSE 26.994 326 216 8 3 317 9 323 2.17E-34 132 SEC1_MOUSE reviewed "Galactoside 2-alpha-L-fucosyltransferase 3 (EC 2.4.1.69) (Alpha(1,2)FT 3) (Fucosyltransferase 10) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 3) (Secretory blood group protein 1)" Sec1 Fut10 Mus musculus (Mouse) 368 protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0008417; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q09324 CHOYP_LOC100375210.3.3 m.43100 sp GCNT1_MOUSE 32.576 396 226 8 94 451 36 428 2.17E-61 209 GCNT1_MOUSE reviewed "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)" Gcnt1 Mus musculus (Mouse) 428 cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; protein glycosylation [GO:0006486]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729] GO:0000139; GO:0003829; GO:0005615; GO:0005802; GO:0006486; GO:0009101; GO:0016021; GO:0031985; GO:0032868; GO:0048729; GO:0050901; GO:0060352; GO:0060993 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02485; Q0P4I1 CHOYP_CEP44.2.2 m.22813 sp CEP44_XENTR 38.728 173 97 1 1 173 1 164 2.17E-34 127 CEP44_XENTR reviewed Centrosomal protein of 44 kDa (Cep44) cep44 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 385 0 GO:0000922; GO:0005737; GO:0005813; GO:0030496 0 0 0 PF15007; Q13309 CHOYP_DANA_GF16815.1.1 m.16998 sp SKP2_HUMAN 33.129 326 209 5 126 449 97 415 2.17E-50 179 SKP2_HUMAN reviewed S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) SKP2 FBXL1 Homo sapiens (Human) 424 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell proliferation [GO:0008283]; cellular response to cell-matrix adhesion [GO:0071460]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726] GO:0000082; GO:0000086; GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0008283; GO:0019005; GO:0031145; GO:0033148; GO:0042802; GO:0042981; GO:0048661; GO:0051726; GO:0061630; GO:0071460; GO:1902916 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; Q1LWV4 CHOYP_LHX9.1.1 m.34566 sp LHX9_DANRE 53.591 362 135 11 49 401 59 396 2.17E-126 373 LHX9_DANRE reviewed LIM/homeobox protein Lhx9 (LIM homeobox protein 9) lhx9 Danio rerio (Zebrafish) (Brachydanio rerio) 396 "motor neuron axon guidance [GO:0008045]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron fate specification [GO:0048665]; thalamus development [GO:0021794]" GO:0003714; GO:0005634; GO:0008045; GO:0008270; GO:0021794; GO:0043565; GO:0045892; GO:0048665 0 0 0 PF00046;PF00412; Q2TA40 CHOYP_LOC100377601.2.2 m.64412 sp NP1L4_BOVIN 61.892 370 128 5 69 435 27 386 2.17E-137 402 NP1L4_BOVIN reviewed Nucleosome assembly protein 1-like 4 NAP1L4 Bos taurus (Bovine) 386 nucleosome assembly [GO:0006334] GO:0005634; GO:0006334 0 0 0 PF00956; Q3Y4E2 CHOYP_LOC100709538.1.2 m.4298 sp SELN_DANRE 38.413 315 159 6 60 342 118 429 2.17E-61 208 SELN_DANRE reviewed Selenoprotein N (SePN) (SelN) sepn1 sepn Danio rerio (Zebrafish) (Brachydanio rerio) 557 calcium-mediated signaling [GO:0019722]; muscle fiber development [GO:0048747]; muscle tissue development [GO:0060537]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; skeletal muscle fiber development [GO:0048741] GO:0005789; GO:0016021; GO:0016491; GO:0019722; GO:0048741; GO:0048747; GO:0060314; GO:0060537 0 0 0 0 Q460N5 CHOYP_PARP14.6.22 m.31720 sp PAR14_HUMAN 26.304 441 256 12 45 468 798 1186 2.17E-31 133 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_CRE_27800.1.1 m.21789 sp SVEP1_HUMAN 33.113 302 161 7 119 388 955 1247 2.17E-32 133 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q568K2 CHOYP_ADA17.1.3 m.798 sp PP1RB_DANRE 55.172 58 26 0 27 84 31 88 2.17E-18 77.4 PP1RB_DANRE reviewed Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) 122 negative regulation of phosphoprotein phosphatase activity [GO:0032515] GO:0000164; GO:0004865; GO:0005634; GO:0032515 0 0 0 PF07491; Q568K2 CHOYP_COX1.12.15 m.53966 sp PP1RB_DANRE 55.172 58 26 0 27 84 31 88 2.17E-18 77.4 PP1RB_DANRE reviewed Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) 122 negative regulation of phosphoprotein phosphatase activity [GO:0032515] GO:0000164; GO:0004865; GO:0005634; GO:0032515 0 0 0 PF07491; Q568K2 CHOYP_PP1RB.1.2 m.40942 sp PP1RB_DANRE 55.172 58 26 0 27 84 31 88 2.17E-18 77.4 PP1RB_DANRE reviewed Protein phosphatase 1 regulatory subunit 11 ppp1r11 zgc:110245 Danio rerio (Zebrafish) (Brachydanio rerio) 122 negative regulation of phosphoprotein phosphatase activity [GO:0032515] GO:0000164; GO:0004865; GO:0005634; GO:0032515 0 0 0 PF07491; Q5F4C0 CHOYP_LOC101077208.1.1 m.9947 sp HVCN1_CHICK 35.965 114 66 2 207 320 100 206 2.17E-11 67.4 HVCN1_CHICK reviewed Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) HVCN1 RCJMB04_1c7 Gallus gallus (Chicken) 235 cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transport [GO:0015992]; response to pH [GO:0009268]; response to zinc ion [GO:0010043] GO:0005887; GO:0009268; GO:0010043; GO:0015992; GO:0016021; GO:0030171; GO:0071294; GO:0071467 0 0 0 PF00520;PF16799; Q5U5M8 CHOYP_ISCW_ISCW004420.5.8 m.23910 sp BL1S3_MOUSE 28.249 177 107 4 7 172 13 180 2.17E-08 54.7 BL1S3_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) (Reduced pigmentation protein) Bloc1s3 Blos3 Rp Mus musculus (Mouse) 195 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to drug [GO:0042493]; secretion of lysosomal enzymes [GO:0033299] GO:0001654; GO:0005737; GO:0005829; GO:0007596; GO:0008089; GO:0008320; GO:0016197; GO:0030133; GO:0030168; GO:0031083; GO:0031175; GO:0032402; GO:0032438; GO:0032816; GO:0033299; GO:0035646; GO:0042493; GO:0043473; GO:0048066; GO:0048490; GO:0060155; GO:1904115 0 0 0 PF15753; Q6P3S1 CHOYP_PHUM_PHUM474960.1.1 m.12414 sp DEN1B_HUMAN 35.762 151 92 2 1 147 330 479 2.17E-20 97.4 DEN1B_HUMAN reviewed DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) DENND1B C1orf218 FAM31B Homo sapiens (Human) 775 endocytic recycling [GO:0032456]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell cytokine production [GO:0035745] GO:0005829; GO:0015031; GO:0017112; GO:0030136; GO:0032456; GO:0035745; GO:0050776; GO:0050852 0 0 0 PF03455;PF02141;PF03456; Q6ZQT0 CHOYP_PEK12.1.1 m.42730 sp YD023_HUMAN 34.821 112 73 0 226 337 8 119 2.17E-09 60.1 YD023_HUMAN reviewed Putative uncharacterized protein FLJ45035 0 Homo sapiens (Human) 140 0 0 0 0 0 0 Q7L2J0 CHOYP_LOC100879901.1.1 m.46057 sp MEPCE_HUMAN 40.262 534 254 11 79 563 169 686 2.17E-113 358 MEPCE_HUMAN reviewed 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) MEPCE BCDIN3 Homo sapiens (Human) 689 negative regulation of chromatin binding [GO:0035562]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; RNA methylation [GO:0001510]; snRNA metabolic process [GO:0016073]; snRNA modification [GO:0040031] GO:0000122; GO:0001510; GO:0008173; GO:0008757; GO:0016073; GO:0035562; GO:0040031; GO:0044822; GO:1900087 0 0 0 PF06859;PF13847; Q86SS6 CHOYP_LOC100883326.2.2 m.59033 sp SYT9_HUMAN 54.372 366 156 4 48 409 110 468 2.17E-130 387 SYT9_HUMAN reviewed Synaptotagmin-9 (Synaptotagmin IX) (SytIX) SYT9 Homo sapiens (Human) 491 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of insulin secretion [GO:0050796]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019905; GO:0030054; GO:0030276; GO:0030667; GO:0030672; GO:0031045; GO:0045956; GO:0048791; GO:0050796; GO:0070382 0 0 0 PF00168; Q8CFI2 CHOYP_MYSP.6.9 m.40723 sp UB2R1_MOUSE 70.563 231 66 1 1 231 1 229 2.17E-117 337 UB2R1_MOUSE reviewed Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) Cdc34 Ubch3 Ube2r1 Mus musculus (Mouse) 235 cell cycle [GO:0007049]; cellular response to interferon-beta [GO:0035458]; negative regulation of cAMP-mediated signaling [GO:0043951]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567] GO:0000209; GO:0004842; GO:0005524; GO:0005654; GO:0005737; GO:0006513; GO:0007049; GO:0016567; GO:0031625; GO:0035458; GO:0043161; GO:0043951; GO:0061630; GO:0061631; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q8K190 CHOYP_LOC662310.1.1 m.18154 sp SMDC1_MOUSE 54.237 59 24 2 91 147 113 170 2.17E-12 64.7 SMDC1_MOUSE reviewed SAYSvFN domain-containing protein 1 Saysd1 Mus musculus (Mouse) 188 0 GO:0016021; GO:0030659; GO:0043231 0 0 0 PF10260; Q8K190 CHOYP_NEMVEDRAFT_V1G238125.1.1 m.44417 sp SMDC1_MOUSE 54.237 59 24 2 91 147 113 170 2.17E-12 64.7 SMDC1_MOUSE reviewed SAYSvFN domain-containing protein 1 Saysd1 Mus musculus (Mouse) 188 0 GO:0016021; GO:0030659; GO:0043231 0 0 0 PF10260; Q8N7X0 CHOYP_ADGB.3.3 m.50806 sp ADGB_HUMAN 32.432 444 197 17 48 475 366 722 2.17E-46 176 ADGB_HUMAN reviewed Androglobin (Calpain-7-like protein) ADGB C6orf103 CAPN7L Homo sapiens (Human) 1667 proteolysis [GO:0006508] GO:0004198; GO:0005737; GO:0006508; GO:0019825; GO:0020037 0 0 0 PF00648; Q90X89 CHOYP_CDX1.1.1 m.11142 sp CDX1_XENTR 74.757 103 25 1 135 237 110 211 2.17E-41 147 CDX1_XENTR reviewed Homeobox protein CDX-1 cdx1 cad2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 262 "anterior/posterior axis specification [GO:0009948]; cell differentiation [GO:0030154]; organ morphogenesis [GO:0009887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0009887; GO:0009948; GO:0030154; GO:0044212; GO:0045944 0 0 0 PF04731;PF00046; Q9FKS8 CHOYP_BRAFLDRAFT_120622.1.1 m.26852 sp LHT1_ARATH 24.611 386 253 13 45 409 40 408 2.17E-16 84.7 LHT1_ARATH reviewed Lysine histidine transporter 1 LHT1 At5g40780 K1B16.3 Arabidopsis thaliana (Mouse-ear cress) 446 amino acid import [GO:0043090]; amino acid transport [GO:0006865]; response to karrikin [GO:0080167] GO:0005886; GO:0006865; GO:0015171; GO:0015293; GO:0016021; GO:0043090; GO:0080167 0 0 0 PF01490; Q9UBX0 CHOYP_LOC100372398.1.1 m.10459 sp HESX1_HUMAN 40.26 77 45 1 12 88 108 183 2.17E-14 72.4 HESX1_HUMAN reviewed Homeobox expressed in ES cells 1 (Homeobox protein ANF) (hAnf) HESX1 HANF Homo sapiens (Human) 185 "brain development [GO:0007420]; forebrain morphogenesis [GO:0048853]; negative regulation of transcription, DNA-templated [GO:0045892]; nose development [GO:0043584]; otic vesicle formation [GO:0030916]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0007420; GO:0030916; GO:0043565; GO:0043584; GO:0045892; GO:0048853 0 0 0 PF00046; Q9ULD9 CHOYP_LOC100123035.1.1 m.11337 sp ZN608_HUMAN 27.504 629 316 34 126 685 919 1476 2.17E-06 55.1 ZN608_HUMAN reviewed Zinc finger protein 608 (Renal carcinoma antigen NY-REN-36) ZNF608 KIAA1281 Homo sapiens (Human) 1512 0 GO:0046872 0 0 0 0 Q9ULJ7 CHOYP_ANK2.3.8 m.35809 sp ANR50_HUMAN 30.841 214 115 6 751 938 548 754 2.17E-16 88.2 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A7YY35 CHOYP_IFRX2.7.10 m.34713 sp K2012_BOVIN 29.832 238 132 6 8 237 2 212 2.18E-19 98.2 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; D3Z5L6 CHOYP_LOC100367304.1.1 m.10800 sp S18B1_MOUSE 42.708 96 55 0 22 117 332 427 2.18E-10 61.2 S18B1_MOUSE reviewed MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) Slc18b1 Mus musculus (Mouse) 459 0 GO:0005887; GO:0022857 0 0 cd06174; PF07690; E9Q394 CHOYP_AKP13.5.5 m.65301 sp AKP13_MOUSE 31.622 740 448 23 1004 1714 1934 2644 2.18E-83 310 AKP13_MOUSE reviewed A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) Akap13 Brx Mus musculus (Mouse) 2776 adrenergic receptor signaling pathway [GO:0071875]; adrenergic receptor signaling pathway involved in heart process [GO:0086023]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; nuclear export [GO:0051168]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cardiac muscle hypertrophy [GO:0010611]; regulation of glucocorticoid mediated signaling pathway [GO:1900169]; regulation of protein kinase activity [GO:0045859]; regulation of sarcomere organization [GO:0060297] GO:0004691; GO:0005078; GO:0005089; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005938; GO:0007186; GO:0007507; GO:0010611; GO:0016020; GO:0017048; GO:0032947; GO:0035025; GO:0035556; GO:0043123; GO:0045859; GO:0046872; GO:0048471; GO:0051018; GO:0051168; GO:0055007; GO:0060297; GO:0060348; GO:0071875; GO:0086023; GO:1900169 0 0 0 PF00621; O60687 CHOYP_LYAM3.1.4 m.1473 sp SRPX2_HUMAN 28.448 232 159 6 68 297 84 310 2.18E-20 97.1 SRPX2_HUMAN reviewed Sushi repeat-containing protein SRPX2 (Sushi-repeat protein upregulated in leukemia) SRPX2 SRPUL Homo sapiens (Human) 465 angiogenesis [GO:0001525]; cell motility [GO:0048870]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphorylation [GO:0042325]; single organismal cell-cell adhesion [GO:0016337]; vocalization behavior [GO:0071625] GO:0001525; GO:0005102; GO:0005615; GO:0005737; GO:0009986; GO:0016337; GO:0030054; GO:0036458; GO:0042325; GO:0042802; GO:0048870; GO:0051965; GO:0060076; GO:0071625; GO:0090050; GO:0097060 0 0 0 PF13778;PF02494;PF00084; P04323 CHOYP_LOC100892528.1.1 m.706 sp POL3_DROME 31.332 766 455 25 462 1172 216 965 2.18E-85 305 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P09815 CHOYP_contig_011939 m.13700 sp ICEN_PSEFL 40.462 173 103 0 40 212 273 445 2.18E-14 74.7 ICEN_PSEFL reviewed Ice nucleation protein inaW Pseudomonas fluorescens 1210 0 GO:0009279; GO:0050825 0 0 0 PF00818; P10079 CHOYP_LOC100634060.36.37 m.65894 sp FBP1_STRPU 53.913 345 157 1 2 346 189 531 2.18E-113 356 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P15870 CHOYP_CAOG_00801.1.2 m.1580 sp H1D_STRPU 59.459 74 28 1 43 116 32 103 2.18E-20 86.7 H1D_STRPU reviewed Histone H1-delta 0 Strongylocentrotus purpuratus (Purple sea urchin) 185 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; P16924 CHOYP_P4HA1.2.5 m.12778 sp P4HA1_CHICK 53.488 129 54 2 4 132 392 514 2.18E-37 136 P4HA1_CHICK reviewed "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 P4HA Gallus gallus (Chicken) 516 0 GO:0004656; GO:0005506; GO:0005788; GO:0016702; GO:0031418 0 0 0 PF13640;PF08336; P26652 CHOYP_LOC100696712.1.1 m.40544 sp TIMP3_CHICK 32.447 188 109 8 20 203 22 195 2.18E-19 85.9 TIMP3_CHICK reviewed Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) 212 negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] GO:0002020; GO:0005578; GO:0005615; GO:0008191; GO:0010033; GO:0043086; GO:0046872; GO:0051045 0 0 0 PF00965; P28799 CHOYP_BRAFLDRAFT_102424.2.6 m.3430 sp GRN_HUMAN 39.492 590 291 16 65 632 46 591 2.18E-119 372 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P43143 CHOYP_BRAFLDRAFT_217596.1.1 m.11072 sp ACHA6_RAT 28.155 412 263 8 17 419 17 404 2.18E-53 189 ACHA6_RAT reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) 493 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of dopamine secretion [GO:0033603]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0033603; GO:0035094; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; P54357 CHOYP_LOC100881900.3.3 m.63739 sp MLC2_DROME 66.667 135 45 0 1 135 13 147 2.18E-64 195 MLC2_DROME reviewed Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain) Mlc-c CG3201 Drosophila melanogaster (Fruit fly) 147 actin filament-based movement [GO:0030048] GO:0005509; GO:0016459; GO:0016460; GO:0017022; GO:0030048; GO:0031475; GO:0031476; GO:0031477; GO:0032036 0 0 0 PF13405;PF13499; P56705 CHOYP_WNT2B.1.3 m.10882 sp WNT4_HUMAN 44.915 354 170 5 11 354 12 350 2.18E-108 323 WNT4_HUMAN reviewed Protein Wnt-4 WNT4 UNQ426/PRO864 Homo sapiens (Human) 351 "adrenal gland development [GO:0030325]; androgen biosynthetic process [GO:0006702]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic epithelial tube formation [GO:0001838]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization to plasma membrane [GO:0090002]; female gonad development [GO:0008585]; female sex determination [GO:0030237]; immature T cell proliferation in thymus [GO:0033080]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; mammary gland epithelium development [GO:0061180]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric nephron morphogenesis [GO:0072273]; metanephric tubule formation [GO:0072174]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of male gonad development [GO:2000019]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of testicular blood vessel morphogenesis [GO:0061369]; negative regulation of testosterone biosynthetic process [GO:2000225]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of wound healing [GO:0061045]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway via MAPK cascade [GO:0038030]; oocyte development [GO:0048599]; paramesonephric duct development [GO:0061205]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cortisol biosynthetic process [GO:2000066]; positive regulation of dermatome development [GO:0061184]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell-cell adhesion [GO:0022407]; renal vesicle formation [GO:0072033]; renal vesicle induction [GO:0072034]; smooth muscle cell differentiation [GO:0051145]; somatotropin secreting cell differentiation [GO:0060126]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; Wnt signaling pathway [GO:0016055]" GO:0001658; GO:0001822; GO:0001837; GO:0001838; GO:0001889; GO:0003714; GO:0005109; GO:0005576; GO:0005578; GO:0005615; GO:0005737; GO:0005788; GO:0005796; GO:0005886; GO:0006702; GO:0008584; GO:0008585; GO:0009267; GO:0009986; GO:0010629; GO:0010894; GO:0016055; GO:0022407; GO:0030182; GO:0030237; GO:0030325; GO:0030336; GO:0030501; GO:0030666; GO:0032349; GO:0032967; GO:0033080; GO:0038030; GO:0040037; GO:0043547; GO:0045165; GO:0045596; GO:0045669; GO:0045836; GO:0045892; GO:0045893; GO:0048018; GO:0048599; GO:0051145; GO:0051496; GO:0051894; GO:0060070; GO:0060126; GO:0060129; GO:0060231; GO:0060748; GO:0061045; GO:0061180; GO:0061184; GO:0061205; GO:0061369; GO:0070062; GO:0071560; GO:0072033; GO:0072034; GO:0072162; GO:0072174; GO:0072273; GO:0090002; GO:0090090; GO:0090263; GO:2000019; GO:2000066; GO:2000225; GO:2001234 0 0 0 PF00110; P62248 CHOYP_LOC101040300.1.2 m.6533 sp MYDGF_BOVIN 38.519 135 73 3 29 154 41 174 2.18E-25 98.2 MYDGF_BOVIN reviewed Myeloid-derived growth factor (MYDGF) MYDGF Bos taurus (Bovine) 174 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001525; GO:0001934; GO:0001938; GO:0005576; GO:0005615; GO:0005793; GO:0006915; GO:0014068; GO:0043066; GO:0043410; GO:0045766; GO:0045944; GO:0051897; GO:0070062 0 0 0 PF10572; P62325 CHOYP_14332.1.2 m.5644 sp BTG1_MOUSE 47.205 161 80 2 1 156 11 171 2.18E-47 155 BTG1_MOUSE reviewed Protein BTG1 (B-cell translocation gene 1 protein) Btg1 Mus musculus (Mouse) 171 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663]; protein methylation [GO:0006479]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0006479; GO:0006979; GO:0007283; GO:0008285; GO:0019899; GO:0043085; GO:0043434; GO:0045603; GO:0045663; GO:0045766; GO:2000271 0 0 0 PF07742; P62325 CHOYP_ACT.9.27 m.24631 sp BTG1_MOUSE 47.205 161 80 2 1 156 11 171 2.18E-47 155 BTG1_MOUSE reviewed Protein BTG1 (B-cell translocation gene 1 protein) Btg1 Mus musculus (Mouse) 171 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663]; protein methylation [GO:0006479]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0006479; GO:0006979; GO:0007283; GO:0008285; GO:0019899; GO:0043085; GO:0043434; GO:0045603; GO:0045663; GO:0045766; GO:2000271 0 0 0 PF07742; P62325 CHOYP_LOC100533387.1.1 m.56132 sp BTG1_MOUSE 47.205 161 80 2 1 156 11 171 2.18E-47 155 BTG1_MOUSE reviewed Protein BTG1 (B-cell translocation gene 1 protein) Btg1 Mus musculus (Mouse) 171 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663]; protein methylation [GO:0006479]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0006479; GO:0006979; GO:0007283; GO:0008285; GO:0019899; GO:0043085; GO:0043434; GO:0045603; GO:0045663; GO:0045766; GO:2000271 0 0 0 PF07742; P62325 CHOYP_PLS2.1.1 m.25964 sp BTG1_MOUSE 47.205 161 80 2 1 156 11 171 2.18E-47 155 BTG1_MOUSE reviewed Protein BTG1 (B-cell translocation gene 1 protein) Btg1 Mus musculus (Mouse) 171 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of catalytic activity [GO:0043085]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663]; protein methylation [GO:0006479]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0006479; GO:0006979; GO:0007283; GO:0008285; GO:0019899; GO:0043085; GO:0043434; GO:0045603; GO:0045663; GO:0045766; GO:2000271 0 0 0 PF07742; P62755 CHOYP_RS6.1.12 m.844 sp RS6_RAT 86.897 145 19 0 1 145 1 145 2.18E-93 275 RS6_RAT reviewed 40S ribosomal protein S6 Rps6 Rattus norvegicus (Rat) 249 cellular response to ethanol [GO:0071361]; glucose homeostasis [GO:0042593]; negative regulation of bicellular tight junction assembly [GO:1903347]; response to insulin [GO:0032868]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0000028; GO:0003729; GO:0003735; GO:0006364; GO:0006412; GO:0022627; GO:0032868; GO:0042593; GO:0071361; GO:1903347 0 0 0 PF01092; P91685 CHOYP_LOC100902836.1.1 m.44597 sp GRM_DROME 73 200 52 1 1 200 697 894 2.18E-97 306 GRM_DROME reviewed Metabotropic glutamate receptor (DmGluRA) mGluR Glu-RA GluRA mGluRA CG11144 Drosophila melanogaster (Fruit fly) 976 "G-protein coupled glutamate receptor signaling pathway [GO:0007216]; neuromuscular junction development [GO:0007528]; regulation of synaptic transmission, glutamatergic [GO:0051966]; terminal button organization [GO:0072553]" GO:0001641; GO:0004930; GO:0005886; GO:0005887; GO:0007216; GO:0007528; GO:0008066; GO:0015485; GO:0016021; GO:0016595; GO:0038038; GO:0045121; GO:0051966; GO:0072553 0 0 0 PF00003;PF01094;PF07562; Q12739 CHOYP_LOC100206475.3.16 m.21124 sp LAC2_PLEOS 35.443 237 136 6 102 327 61 291 2.18E-36 142 LAC2_PLEOS reviewed Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Urishiol oxidase 2) POX2 Pleurotus ostreatus (Oyster mushroom) (White-rot fungus) 533 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q15582 CHOYP_ISCW_ISCW001538.1.1 m.1776 sp BGH3_HUMAN 32.743 113 71 3 4 115 263 371 2.18E-11 63.2 BGH3_HUMAN reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) TGFBI BIGH3 Homo sapiens (Human) 683 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; cellular protein metabolic process [GO:0044267]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0001525; GO:0002062; GO:0005178; GO:0005518; GO:0005576; GO:0005578; GO:0005604; GO:0005615; GO:0005802; GO:0005886; GO:0007155; GO:0007162; GO:0007601; GO:0008283; GO:0030198; GO:0031012; GO:0044267; GO:0050840; GO:0050896; GO:0070062 0 0 0 PF02469; Q32KL8 CHOYP_LOC100377392.2.4 m.21903 sp TBATA_BOVIN 29.242 277 124 10 19 282 38 255 2.18E-21 98.2 TBATA_BOVIN reviewed "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)" TBATA SPATIAL Bos taurus (Bovine) 333 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005829; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q4A3R3 CHOYP_BRAFLDRAFT_120139.2.5 m.14993 sp DMBT1_PIG 28.516 512 305 16 37 531 648 1115 2.18E-39 160 DMBT1_PIG reviewed Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) 1204 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0007275; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0035375; GO:0042589 0 0 0 PF00431;PF00530;PF00100; Q54TR1 CHOYP_NEMVEDRAFT_V1G185623.1.1 m.62696 sp CFAD_DICDI 34.457 534 331 11 25 549 4 527 2.18E-95 303 CFAD_DICDI reviewed Counting factor associated protein D cfaD DDB_G0281605 Dictyostelium discoideum (Slime mold) 531 negative regulation of asexual reproduction [GO:1903665]; positive regulation of chemorepellent activity [GO:1903669]; protein localization to plasma membrane [GO:0072659]; sorocarp morphogenesis [GO:0031288]; sporulation resulting in formation of a cellular spore [GO:0030435] GO:0005576; GO:0005615; GO:0005764; GO:0030435; GO:0031288; GO:0031410; GO:0072659; GO:1903665; GO:1903669 0 0 0 PF08246;PF00112; Q5ZMS6 CHOYP_TDRD3.1.2 m.3301 sp TDRD3_CHICK 41.045 402 182 8 22 385 7 391 2.18E-79 273 TDRD3_CHICK reviewed Tudor domain-containing protein 3 TDRD3 RCJMB04_1e24 Gallus gallus (Chicken) 741 covalent chromatin modification [GO:0016569]; mRNA processing [GO:0006397] GO:0003682; GO:0003713; GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0016569; GO:0035064 0 0 0 PF08585;PF06003;PF00627; Q6NYR8 CHOYP_NPL.2.3 m.27840 sp NPL_DANRE 50 116 56 2 37 150 7 122 2.18E-33 122 NPL_DANRE reviewed N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) npl zgc:76930 Danio rerio (Zebrafish) (Brachydanio rerio) 307 carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262] GO:0005737; GO:0005975; GO:0008747; GO:0019262 PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. 0 cd00954; PF00701; Q6Q899 CHOYP_IFIH1.13.14 m.65199 sp DDX58_MOUSE 29.615 493 286 17 135 588 14 484 2.18E-50 191 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q8BGD9 CHOYP_EIF4BA.1.1 m.18165 sp IF4B_MOUSE 46.269 201 74 3 18 184 68 268 2.18E-38 142 IF4B_MOUSE reviewed Eukaryotic translation initiation factor 4B (eIF-4B) Eif4b Mus musculus (Mouse) 611 cytoplasmic translation [GO:0002181]; eukaryotic translation initiation factor 4F complex assembly [GO:0097010]; formation of translation preinitiation complex [GO:0001731] GO:0000166; GO:0001731; GO:0002181; GO:0003743; GO:0005844; GO:0016281; GO:0033592; GO:0034057; GO:0043024; GO:0044822; GO:0097010 0 0 0 PF00076; Q8BT14 CHOYP_SYAC.1.2 m.15847 sp CNOT4_MOUSE 43.082 318 130 10 16 327 154 426 2.18E-56 199 CNOT4_MOUSE reviewed CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) Cnot4 Not4 Mus musculus (Mouse) 575 "protein autoubiquitination [GO:0051865]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0004842; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0016874; GO:0030014; GO:0044822; GO:0051865 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00076; Q8BV66 CHOYP_BRAFLDRAFT_91636.6.11 m.49144 sp IFI44_MOUSE 28.821 458 279 9 1 456 3 415 2.18E-49 177 IFI44_MOUSE reviewed Interferon-induced protein 44 (Microtubule-associated protein 44) Ifi44 Mtap44 Mus musculus (Mouse) 422 0 GO:0005737 0 0 0 PF07534; Q8JZL1 CHOYP_LOC100709254.1.1 m.6868 sp I17RD_MOUSE 29.703 303 186 9 23 305 264 559 2.18E-27 120 I17RD_MOUSE reviewed Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (Interleukin-17 receptor-like protein) (Sef homolog) (mSef) Il17rd Il17rlm Sef Mus musculus (Mouse) 738 0 GO:0000139; GO:0005654; GO:0005794; GO:0005887; GO:0030368; GO:0046872 0 0 0 PF16742;PF08357; Q95209 CHOYP_PHUM_PHUM066670.1.3 m.2316 sp SORL_RABIT 33.719 519 233 20 366 820 1076 1547 2.18E-52 205 SORL_RABIT reviewed Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 Oryctolagus cuniculus (Rabbit) 2213 cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897]; lipid transport [GO:0006869]; protein targeting [GO:0006605]; regulation of smooth muscle cell migration [GO:0014910] GO:0005615; GO:0005768; GO:0005794; GO:0006605; GO:0006869; GO:0006897; GO:0008203; GO:0014910; GO:0016020; GO:0016021; GO:0034362 0 0 0 PF00041;PF00057;PF00058;PF15902;PF15901; Q95M17 CHOYP_CHIA.2.3 m.3381 sp CHIA_BOVIN 37.956 411 218 9 35 430 1 389 2.18E-85 274 CHIA_BOVIN reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Chitin-binding protein b04) (CBPb04) CHIA Bos taurus (Bovine) 472 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532] GO:0000272; GO:0002376; GO:0002532; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0006032; GO:0006915; GO:0008061; GO:0090197 0 0 0 PF01607;PF00704; Q96LT7 CHOYP_CI072.1.1 m.45199 sp CI072_HUMAN 28.412 447 285 8 42 454 8 453 2.18E-54 191 CI072_HUMAN reviewed Protein C9orf72 C9orf72 Homo sapiens (Human) 481 autophagy [GO:0006914]; endocytosis [GO:0006897] GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005768; GO:0005776; GO:0006897; GO:0006914; GO:0015629; GO:0017137; GO:0031410; GO:0045171 0 0 0 PF15019; Q99PP7 CHOYP_NEMVEDRAFT_V1G238127.2.2 m.61614 sp TRI33_MOUSE 23.423 333 228 10 34 349 153 475 2.18E-14 80.1 TRI33_MOUSE reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Trim33 Kiaa1113 Mus musculus (Mouse) 1142 "negative regulation of BMP signaling pathway [GO:0030514]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q9ESN6 CHOYP_LOC100373444.4.79 m.3199 sp TRIM2_MOUSE 28.502 207 113 9 328 521 523 707 2.18E-10 67 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NUV9 CHOYP_LOC100554223.1.1 m.34354 sp GIMA4_HUMAN 57.944 107 45 0 593 699 27 133 2.18E-34 137 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9QXN5 CHOYP_BRAFLDRAFT_279937.1.1 m.49979 sp MIOX_MOUSE 54.448 281 122 2 20 294 5 285 2.18E-111 326 MIOX_MOUSE reviewed Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase) Miox Aldrl6 Rsor Mus musculus (Mouse) 285 inositol catabolic process [GO:0019310] GO:0004033; GO:0005737; GO:0008199; GO:0016234; GO:0016491; GO:0016651; GO:0016701; GO:0019310; GO:0050113; GO:0070062 PATHWAY: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1. 0 0 PF05153; Q9TTS3 CHOYP_ACACA.6.7 m.62809 sp ACACA_BOVIN 66.57 344 108 3 20 358 1439 1780 2.18E-150 471 ACACA_BOVIN reviewed Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACACA ACAC ACCA Bos taurus (Bovine) 2346 acetyl-CoA metabolic process [GO:0006084]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289] GO:0003989; GO:0004075; GO:0005524; GO:0005829; GO:0006084; GO:0006633; GO:0046872; GO:0051289; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; Q9UGM3 CHOYP_BRAFLDRAFT_68915.1.7 m.2562 sp DMBT1_HUMAN 45.397 478 213 8 4 437 488 961 2.18E-107 353 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9WTS8 CHOYP_NEMVEDRAFT_V1G228654.2.2 m.33507 sp FCN1_RAT 41.477 176 95 6 665 836 162 333 2.18E-30 126 FCN1_RAT reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Rattus norvegicus (Rat) 335 cell surface pattern recognition receptor signaling pathway [GO:0002752]; G-protein coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; positive regulation of interleukin-8 secretion [GO:2000484] GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0045087; GO:0046872; GO:2000484 0 0 0 PF01391;PF00147; Q9Y6F1 CHOYP_BRAFLDRAFT_203655.1.2 m.10 sp PARP3_HUMAN 39.674 184 97 6 8 180 47 227 2.18E-27 110 PARP3_HUMAN reviewed Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) PARP3 ADPRT3 ADPRTL3 Homo sapiens (Human) 533 DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; lagging strand elongation [GO:0006273]; positive regulation of DNA ligation [GO:0051106]; protein ADP-ribosylation [GO:0006471]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723] GO:0000723; GO:0003824; GO:0003910; GO:0003950; GO:0005634; GO:0005737; GO:0005814; GO:0006273; GO:0006281; GO:0006302; GO:0006471; GO:0035861; GO:0051103; GO:0051106; GO:0060236; GO:1990166 0 0 0 PF00644;PF02877;PF05406; A7RT29 CHOYP_LOC577730.2.5 m.11065 sp LTOR5_NEMVE 45.946 74 39 1 38 110 17 90 2.19E-16 71.2 LTOR5_NEMVE reviewed Ragulator complex protein LAMTOR5 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) v1g226489 Nematostella vectensis (Starlet sea anemone) 91 cellular response to amino acid stimulus [GO:0071230]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]; viral genome replication [GO:0019079] GO:0005764; GO:0008361; GO:0019079; GO:0032008; GO:0043154; GO:0043547; GO:0061462; GO:0071230; GO:0071986 0 0 0 PF16672; O14522 CHOYP_LOC100208023.5.8 m.43025 sp PTPRT_HUMAN 25.373 201 137 4 6 195 1205 1403 2.19E-08 56.6 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O19010 CHOYP_LOC100371737.1.1 m.24715 sp CRIS3_HORSE 39.674 184 88 6 1 162 59 241 2.19E-32 124 CRIS3_HORSE reviewed Cysteine-rich secretory protein 3 (CRISP-3) (Acidic epididymal glycoprotein 2) (AEG2) CRISP3 Equus caballus (Horse) 245 fertilization [GO:0009566]; single organismal cell-cell adhesion [GO:0016337]; spermatogenesis [GO:0007283] GO:0005576; GO:0007283; GO:0009566; GO:0016337; GO:0042581 0 0 0 PF00188;PF08562; O35625 CHOYP_LOC100016298.1.1 m.59409 sp AXIN1_MOUSE 32.993 979 444 39 15 909 13 863 2.19E-99 333 AXIN1_MOUSE reviewed Axin-1 (Axis inhibition protein 1) (Protein Fused) Axin1 Axin Fu Mus musculus (Mouse) 863 "activation of JUN kinase activity [GO:0007257]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axial mesoderm development [GO:0048318]; axial mesoderm formation [GO:0048320]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [GO:0060823]; cell death [GO:0008219]; cellular protein complex assembly [GO:0043623]; cellular response to organic cyclic compound [GO:0071407]; cytoplasmic microtubule organization [GO:0031122]; determination of left/right symmetry [GO:0007368]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; embryonic eye morphogenesis [GO:0048048]; forebrain anterior/posterior pattern specification [GO:0021797]; genetic imprinting [GO:0071514]; in utero embryonic development [GO:0001701]; muscle cell development [GO:0055001]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of protein metabolic process [GO:0051248]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; negative regulation of Wnt signaling pathway [GO:0030178]; nucleocytoplasmic transport [GO:0006913]; olfactory placode formation [GO:0030910]; optic placode formation [GO:0001743]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; post-anal tail morphogenesis [GO:0036342]; protein catabolic process [GO:0030163]; protein homooligomerization [GO:0051260]; protein polyubiquitination [GO:0000209]; regulation of catenin import into nucleus [GO:0035412]; regulation of protein phosphorylation [GO:0001932]; sensory perception of sound [GO:0007605]; Wnt-activated signaling pathway involved in forebrain neuron fate commitment [GO:0021881]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0000209; GO:0001701; GO:0001743; GO:0001932; GO:0001934; GO:0002039; GO:0004871; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005938; GO:0006913; GO:0006915; GO:0007257; GO:0007368; GO:0007605; GO:0008013; GO:0008022; GO:0008219; GO:0009950; GO:0009953; GO:0010800; GO:0014069; GO:0016023; GO:0016055; GO:0016328; GO:0019899; GO:0019901; GO:0019904; GO:0021797; GO:0021881; GO:0030163; GO:0030178; GO:0030511; GO:0030877; GO:0030910; GO:0031122; GO:0031398; GO:0031625; GO:0032147; GO:0032436; GO:0032947; GO:0033138; GO:0034244; GO:0035412; GO:0036342; GO:0042802; GO:0042803; GO:0043234; GO:0043507; GO:0043621; GO:0043623; GO:0045599; GO:0045732; GO:0045860; GO:0045893; GO:0046330; GO:0046332; GO:0048048; GO:0048318; GO:0048320; GO:0048471; GO:0051248; GO:0051260; GO:0051443; GO:0055001; GO:0060070; GO:0060823; GO:0070016; GO:0070411; GO:0070412; GO:0071407; GO:0071514; GO:0071944; GO:0090090; GO:0090244; GO:1904886; GO:1990909; GO:2000060 0 0 cd11582; PF16646;PF08833;PF00778;PF00615; O43312 CHOYP_MTSS1.2.5 m.36898 sp MTSS1_HUMAN 63.082 279 99 1 1 279 1 275 2.19E-117 376 MTSS1_HUMAN reviewed Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) 755 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; movement of cell or subcellular component [GO:0006928]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of defense response to virus by host [GO:0002230]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; xenophagy [GO:0098792] GO:0001726; GO:0002230; GO:0003785; GO:0005102; GO:0005737; GO:0006928; GO:0007009; GO:0007155; GO:0007169; GO:0015629; GO:0030035; GO:0030036; GO:0030139; GO:0042802; GO:0050680; GO:0061333; GO:0071498; GO:0072102; GO:0072160; GO:0098792; GO:2001013 0 0 0 PF08397;PF02205; O50655 CHOYP_LOC100001324.2.3 m.21462 sp XERD_SELRU 28.213 319 187 11 165 464 34 329 2.19E-14 77.8 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O75095 CHOYP_LOC100184792.3.3 m.58439 sp MEGF6_HUMAN 40.278 216 114 9 13 224 857 1061 2.19E-29 122 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P04634 CHOYP_BRAFLDRAFT_131171.1.1 m.43270 sp LIPG_RAT 53.117 369 173 0 88 456 27 395 2.19E-149 434 LIPG_RAT reviewed Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) (Lingual lipase) Lipf Rattus norvegicus (Rat) 395 digestion [GO:0007586]; lipid catabolic process [GO:0016042]; malate metabolic process [GO:0006108] GO:0004806; GO:0005576; GO:0005739; GO:0006108; GO:0007586; GO:0016042; GO:0016298; GO:0016615 0 0 0 PF00561; P34641 CHOYP_LOC584520.1.2 m.29342 sp CED11_CAEEL 22.921 938 543 27 550 1420 451 1275 2.19E-58 226 CED11_CAEEL reviewed Protein ced-11 (Cell death protein 11) ced-11 ZK512.3 Caenorhabditis elegans 1418 apoptotic process [GO:0006915] GO:0006915; GO:0016021 0 0 0 0 P42620 CHOYP_LOC100374338.1.1 m.44584 sp YQJG_ECOLI 57.426 303 116 4 257 551 21 318 2.19E-115 348 YQJG_ECOLI reviewed Glutathionyl-hydroquinone reductase YqjG (GS-HQR) (EC 1.8.-.-) yqjG b3102 JW3073 Escherichia coli (strain K12) 328 0 GO:0016491 0 0 0 PF13409; P97281 CHOYP_LOC100712221.1.1 m.17151 sp SGCD_MESAU 37.906 277 156 5 28 300 24 288 2.19E-51 173 SGCD_MESAU reviewed Delta-sarcoglycan (Delta-SG) (35 kDa dystrophin-associated glycoprotein) (35DAG) SGCD Mesocricetus auratus (Golden hamster) 289 0 GO:0005737; GO:0005856; GO:0016012; GO:0016021; GO:0042383 0 0 0 PF04790; Q02962 CHOYP_PAX2A.1.2 m.10577 sp PAX2_HUMAN 67.123 219 39 7 79 286 16 212 2.19E-83 269 PAX2_HUMAN reviewed Paired box protein Pax-2 PAX2 Homo sapiens (Human) 417 "aging [GO:0007568]; axonogenesis [GO:0007409]; brain morphogenesis [GO:0048854]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cell fate determination [GO:0001709]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucose stimulus [GO:0071333]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cochlea development [GO:0090102]; cochlea morphogenesis [GO:0090103]; glial cell differentiation [GO:0010001]; inner ear morphogenesis [GO:0042472]; mesenchymal to epithelial transition [GO:0060231]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesodermal cell fate specification [GO:0007501]; mesonephros development [GO:0001823]; metanephric collecting duct development [GO:0072205]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchyme development [GO:0072075]; metanephric nephron tubule formation [GO:0072289]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cytolysis [GO:0045918]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription, DNA-templated [GO:0045892]; nephric duct formation [GO:0072179]; neural tube closure [GO:0001843]; optic chiasma development [GO:0061360]; optic cup morphogenesis involved in camera-type eye development [GO:0002072]; optic nerve development [GO:0021554]; optic nerve morphogenesis [GO:0021631]; optic nerve structural organization [GO:0021633]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of metanephric glomerulus development [GO:0072300]; positive regulation of optic nerve formation [GO:2000597]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; protein kinase B signaling [GO:0043491]; reactive oxygen species metabolic process [GO:0072593]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of metanephros size [GO:0035566]; response to nutrient levels [GO:0031667]; retinal pigment epithelium development [GO:0003406]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; ureter development [GO:0072189]; ureter maturation [GO:0035799]; urogenital system development [GO:0001655]; vestibulocochlear nerve formation [GO:0021650]; visual perception [GO:0007601]" GO:0000987; GO:0001655; GO:0001658; GO:0001709; GO:0001823; GO:0001843; GO:0002072; GO:0003337; GO:0003406; GO:0003677; GO:0005634; GO:0005730; GO:0005764; GO:0005794; GO:0005815; GO:0006351; GO:0006366; GO:0007409; GO:0007501; GO:0007568; GO:0007601; GO:0008134; GO:0010001; GO:0016175; GO:0021554; GO:0021631; GO:0021633; GO:0021650; GO:0031667; GO:0032993; GO:0034451; GO:0035566; GO:0035799; GO:0039003; GO:0042472; GO:0043010; GO:0043066; GO:0043069; GO:0043154; GO:0043234; GO:0043491; GO:0044212; GO:0045892; GO:0045893; GO:0045918; GO:0045944; GO:0048793; GO:0048854; GO:0048863; GO:0050679; GO:0060231; GO:0061360; GO:0070301; GO:0071300; GO:0071333; GO:0071364; GO:0072075; GO:0072108; GO:0072162; GO:0072179; GO:0072189; GO:0072205; GO:0072207; GO:0072221; GO:0072289; GO:0072300; GO:0072305; GO:0072307; GO:0072593; GO:0090102; GO:0090103; GO:0090190; GO:1900212; GO:1900215; GO:1900218; GO:2000378; GO:2000594; GO:2000597 0 0 0 PF00292;PF12403; Q03017 CHOYP_LOC100313676.1.2 m.2193 sp CACT_DROME 36.885 244 129 3 195 415 222 463 2.19E-37 145 CACT_DROME reviewed NF-kappa-B inhibitor cactus cact CG5848 Drosophila melanogaster (Fruit fly) 500 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cellular response to DNA damage stimulus [GO:0006974]; cytoplasmic sequestering of transcription factor [GO:0042994]; defense response [GO:0006952]; dorsal/ventral axis specification [GO:0009950]; dorsal appendage formation [GO:0046843]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; phagocytosis [GO:0006909]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; response to fungus [GO:0009620]; Toll signaling pathway [GO:0008063] GO:0005737; GO:0006909; GO:0006952; GO:0006955; GO:0006967; GO:0006974; GO:0007399; GO:0008063; GO:0008134; GO:0009620; GO:0009950; GO:0019730; GO:0019732; GO:0030097; GO:0031594; GO:0042994; GO:0045087; GO:0046843; GO:0048477 0 0 0 PF12796; Q0VD32 CHOYP_LOC101073555.1.1 m.63883 sp CRBL2_BOVIN 69.737 76 20 1 32 104 13 88 2.19E-30 114 CRBL2_BOVIN reviewed cAMP-responsive element-binding protein-like 2 CREBL2 Bos taurus (Bovine) 120 "cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription, DNA-templated [GO:0045893]; protein stabilization [GO:0050821]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0003700; GO:0005634; GO:0006351; GO:0016032; GO:0016604; GO:0030154; GO:0033138; GO:0043565; GO:0045600; GO:0045893; GO:0046326; GO:0046889; GO:0050821 0 0 0 PF07716; Q13591 CHOYP_PHUM_PHUM361010.1.1 m.19081 sp SEM5A_HUMAN 39.935 308 166 6 4 310 468 757 2.19E-68 235 SEM5A_HUMAN reviewed Semaphorin-5A (Semaphorin-F) (Sema F) SEMA5A SEMAF Homo sapiens (Human) 1074 axonal fasciculation [GO:0007413]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell chemotaxis [GO:0060326]; diencephalon development [GO:0021536]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of cell adhesion [GO:0007162]; negative regulation of endothelial cell apoptotic process [GO:2000352]; nervous system development [GO:0007399]; neural crest cell migration [GO:0001755]; positive chemotaxis [GO:0050918]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein kinase B signaling [GO:0051897]; semaphorin-plexin signaling pathway [GO:0071526]; signal clustering [GO:1990256] GO:0001755; GO:0001938; GO:0002043; GO:0005886; GO:0007155; GO:0007162; GO:0007267; GO:0007399; GO:0007413; GO:0016020; GO:0016021; GO:0021536; GO:0030215; GO:0030335; GO:0030836; GO:0035373; GO:0035413; GO:0043395; GO:0045499; GO:0045545; GO:0045766; GO:0048842; GO:0048843; GO:0050918; GO:0051897; GO:0060326; GO:0070062; GO:0071526; GO:1990256; GO:2000352; GO:2001028 0 0 0 PF01403;PF00090; Q14831 CHOYP_BRAFLDRAFT_90929.1.1 m.54455 sp GRM7_HUMAN 27.789 475 300 13 538 988 46 501 2.19E-46 184 GRM7_HUMAN reviewed Metabotropic glutamate receptor 7 (mGluR7) GRM7 GPRC1G MGLUR7 Homo sapiens (Human) 915 "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [GO:0007196]; adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; conditioned taste aversion [GO:0001661]; multicellular organismal response to stress [GO:0033555]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of glutamate secretion [GO:0014050]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of smell [GO:0007608]; sensory perception of sound [GO:0007605]; short-term memory [GO:0007614]; transmission of nerve impulse [GO:0019226]" GO:0001642; GO:0001661; GO:0005245; GO:0005246; GO:0005509; GO:0005886; GO:0005887; GO:0005938; GO:0007194; GO:0007196; GO:0007268; GO:0007605; GO:0007608; GO:0007614; GO:0008066; GO:0010855; GO:0014050; GO:0016021; GO:0016595; GO:0019226; GO:0030165; GO:0030424; GO:0030425; GO:0030534; GO:0030818; GO:0032279; GO:0033555; GO:0042734; GO:0043198; GO:0043235; GO:0045211; GO:0048786; GO:0051966; GO:0070905 0 0 0 PF00003;PF01094;PF07562; Q20681 CHOYP_NEMVEDRAFT_V1G213290.2.2 m.54383 sp BAT38_CAEEL 40 95 55 2 27 120 229 322 2.19E-11 65.9 BAT38_CAEEL reviewed BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans 387 0 0 0 0 0 PF00651;PF00917; Q2TBI0 CHOYP_LOC589952.2.5 m.21623 sp LBP_BOVIN 26.898 461 321 6 22 476 28 478 2.19E-52 187 LBP_BOVIN reviewed Lipopolysaccharide-binding protein (LBP) LBP Bos taurus (Bovine) 481 acute-phase response [GO:0006953]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; macrophage activation involved in immune response [GO:0002281]; positive regulation of tumor necrosis factor production [GO:0032760] GO:0001530; GO:0002281; GO:0005615; GO:0006869; GO:0006953; GO:0016020; GO:0032760; GO:0045087; GO:0050829; GO:0071222 0 0 0 PF01273;PF02886; Q54KD0 CHOYP_TRIADDRAFT_59003.1.1 m.62408 sp Y7407_DICDI 24.611 321 196 7 12 300 369 675 2.19E-26 112 Y7407_DICDI reviewed TPR repeat-containing protein DDB_G0287407 DDB_G0287407 Dictyostelium discoideum (Slime mold) 1663 0 0 0 0 0 PF13271; Q58CS8 CHOYP_GNPTG.2.2 m.62318 sp GNPTG_BOVIN 48.848 217 103 1 35 251 55 263 2.19E-69 219 GNPTG_BOVIN reviewed N-acetylglucosamine-1-phosphotransferase subunit gamma (GlcNAc-1-phosphotransferase subunit gamma) (UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma) GNPTG Bos taurus (Bovine) 306 carbohydrate phosphorylation [GO:0046835] GO:0005794; GO:0042803; GO:0046835; GO:0070062 0 0 0 PF13015; Q642A0 CHOYP_PDRG1.1.3 m.15550 sp PDRG1_RAT 45.669 127 68 1 6 131 5 131 2.19E-33 116 PDRG1_RAT reviewed p53 and DNA damage-regulated protein 1 Pdrg1 Rattus norvegicus (Rat) 133 protein folding [GO:0006457] GO:0005737; GO:0006457; GO:0016272 0 0 0 PF01920; Q7RTX9 CHOYP_LOC100749709.1.1 m.6142 sp MOT14_HUMAN 23.077 442 272 9 4 443 119 494 2.19E-26 115 MOT14_HUMAN reviewed Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) 510 0 GO:0005886; GO:0008028; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q7YQK4 CHOYP_LOC100377923.1.1 m.55711 sp LAT1_RABIT 44.928 483 255 6 1 478 27 503 2.19E-131 392 LAT1_RABIT reviewed Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (L-type amino acid transporter 1) (LAT1 light chain) (Solute carrier family 7 member 5) SLC7A5 Oryctolagus cuniculus (Rabbit) 503 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; neutral amino acid transport [GO:0015804] GO:0005829; GO:0007399; GO:0015171; GO:0015804; GO:0016021; GO:0016324; GO:0030154; GO:0042605 0 0 0 PF13520; Q8HXX6 CHOYP_BRAFLDRAFT_124972.3.5 m.12860 sp SAP3_MACFA 33.526 173 103 4 54 215 16 187 2.19E-30 113 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8R1X6 CHOYP_LOC100892454.1.1 m.24759 sp SPG20_MOUSE 32.166 628 304 15 34 549 14 631 2.19E-84 279 SPG20_MOUSE reviewed Spartin Spg20 Kiaa0610 Mus musculus (Mouse) 671 abscission [GO:0009838]; adipose tissue development [GO:0060612]; cell division [GO:0051301]; lipid particle organization [GO:0034389]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of collateral sprouting in absence of injury [GO:0048698]; neuromuscular process [GO:0050905]; regulation of mitochondrial membrane potential [GO:0051881] GO:0005741; GO:0005811; GO:0005886; GO:0009838; GO:0030496; GO:0030514; GO:0034389; GO:0045202; GO:0048698; GO:0050905; GO:0051301; GO:0051881; GO:0060612 0 0 0 PF06911; Q95KB4 CHOYP_LOC101069141.1.1 m.61824 sp S35B4_MACFA 50.733 341 155 3 17 354 1 331 2.19E-117 345 S35B4_MACFA reviewed UDP-xylose and UDP-N-acetylglucosamine transporter (Solute carrier family 35 member B4) SLC35B4 QccE-22467 QmoA-11096 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 331 carbohydrate transport [GO:0008643]; transmembrane transport [GO:0055085] GO:0000139; GO:0008643; GO:0016021; GO:0055085 0 0 0 PF08449; Q96MM6 CHOYP_HSPA12A.15.27 m.45635 sp HS12B_HUMAN 30.255 628 363 17 888 1444 61 684 2.19E-74 266 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BTE0 CHOYP_LOC100566602.1.1 m.30119 sp NAT9_HUMAN 55.932 177 74 3 1 173 1 177 2.19E-63 197 NAT9_HUMAN reviewed N-acetyltransferase 9 (EC 2.3.1.-) (Embryo brain-specific protein) NAT9 EBS Homo sapiens (Human) 207 N-terminal protein amino acid acetylation [GO:0006474] GO:0006474; GO:0008080; GO:0043234 0 0 0 PF13302; Q9CWY3 CHOYP_SETD6.1.1 m.14704 sp SETD6_MOUSE 38.557 485 253 11 10 465 1 469 2.19E-96 301 SETD6_MOUSE reviewed N-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6) Setd6 Mus musculus (Mouse) 473 histone lysine methylation [GO:0034968]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; peptidyl-lysine monomethylation [GO:0018026]; regulation of inflammatory response [GO:0050727]; stem cell differentiation [GO:0048863]; stem cell population maintenance [GO:0019827] GO:0005634; GO:0005737; GO:0016279; GO:0018026; GO:0019827; GO:0032088; GO:0034968; GO:0048863; GO:0050727; GO:0051059 0 0 0 PF09273;PF00856; Q9ESN6 CHOYP_LOC100373444.13.79 m.13486 sp TRIM2_MOUSE 27.485 171 110 6 350 515 536 697 2.19E-06 54.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAR2 CHOYP_LOC100892167.1.1 m.41614 sp AGRL3_HUMAN 26.667 300 191 10 506 790 857 1142 2.19E-17 91.3 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9IBG7 CHOYP_KCP.2.13 m.7130 sp KCP_XENLA 41.165 498 271 15 2 481 993 1486 2.19E-84 287 KCP_XENLA reviewed Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) 2327 0 GO:0005576 0 0 0 PF00093;PF00094; Q9NQA5 CHOYP_LOC100533351.3.3 m.52581 sp TRPV5_HUMAN 20.705 454 279 16 120 523 166 588 2.19E-10 67.4 TRPV5_HUMAN reviewed Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) TRPV5 ECAC1 Homo sapiens (Human) 729 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; protein tetramerization [GO:0051262] GO:0005262; GO:0005886; GO:0005887; GO:0006816; GO:0016324; GO:0051262; GO:0070588 0 0 0 PF00023;PF12796;PF00520; Q9UH77 CHOYP_LOC101157944.1.1 m.46718 sp KLHL3_HUMAN 39.796 98 57 2 268 363 401 498 2.19E-14 78.2 KLHL3_HUMAN reviewed Kelch-like protein 3 KLHL3 KIAA1129 Homo sapiens (Human) 587 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005198; GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q9UTR8 CHOYP_ZFC3H1.1.2 m.6167 sp YLP3_SCHPO 42.857 77 43 1 1229 1304 579 655 2.19E-12 76.3 YLP3_SCHPO reviewed Protein red1 (RNA elimination defective protein 1) red1 SPAC1006.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 712 "negative regulation of meiotic cell cycle [GO:0051447]; nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts [GO:0033621]; regulation of heterochromatin domain assembly [GO:1902802]; regulation of heterochromatin island assembly [GO:1902801]; regulation of snoRNA processing [GO:1902796]" GO:0005634; GO:0016604; GO:0033621; GO:0046872; GO:0051447; GO:1902796; GO:1902801; GO:1902802; GO:1990251; GO:1990342; GO:1990345; GO:1990477 0 0 0 PF10650; Q9VCA8 CHOYP_LOC583072.1.25 m.323 sp ANKHM_DROME 29.707 478 295 17 360 821 550 1002 2.19E-33 143 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VGG5 CHOYP_CAD87.1.1 m.40863 sp CAD87_DROME 30.247 162 91 6 44 187 1007 1164 2.19E-11 65.5 CAD87_DROME reviewed Cadherin-87A Cad87A CG6977 Drosophila melanogaster (Fruit fly) 1975 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005887; GO:0007156; GO:0016339; GO:0044331 0 0 0 PF00028; Q9WVH6 CHOYP_BRAFLDRAFT_108085.2.3 m.38124 sp ANGP4_MOUSE 52.381 84 39 1 17 100 293 375 2.19E-29 112 ANGP4_MOUSE reviewed Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) 509 angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; endoderm development [GO:0007492]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; Tie signaling pathway [GO:0048014] GO:0001525; GO:0005172; GO:0005615; GO:0007219; GO:0007492; GO:0010595; GO:0016525; GO:0030297; GO:0030971; GO:0043066; GO:0043536; GO:0043537; GO:0045766; GO:0048014; GO:0050731; GO:0071456 0 0 0 PF00147; Q9Y547 CHOYP_LOC764898.1.1 m.28118 sp IFT25_HUMAN 46.667 135 72 0 3 137 5 139 2.19E-41 137 IFT25_HUMAN reviewed Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25) HSPB11 C1orf41 IFT25 HSPC034 Homo sapiens (Human) 144 heart development [GO:0007507]; intraciliary transport [GO:0042073]; left/right axis specification [GO:0070986]; lung development [GO:0030324]; skeletal system development [GO:0001501]; smoothened signaling pathway [GO:0007224] GO:0001501; GO:0005813; GO:0007224; GO:0007507; GO:0030324; GO:0030992; GO:0042073; GO:0046872; GO:0070062; GO:0070986; GO:0072372; GO:0097542 0 0 0 PF00754; A4IF63 CHOYP_BRAFLDRAFT_87285.1.8 m.13248 sp TRIM2_BOVIN 25.161 155 102 4 561 712 600 743 2.20E-06 55.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6BM72 CHOYP_MEG10.56.91 m.47514 sp MEG11_HUMAN 38.365 318 174 14 70 381 349 650 2.20E-41 159 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; D2GXS7 CHOYP_BRAFLDRAFT_86897.2.3 m.54749 sp TRIM2_AILME 24.793 242 136 11 192 387 490 731 2.20E-08 59.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15018 CHOYP_LOC100370705.1.2 m.30943 sp PDZD2_HUMAN 45.882 85 46 0 964 1048 2755 2839 2.20E-16 88.6 PDZD2_HUMAN reviewed PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] PDZD2 AIPC KIAA0300 PDZK3 Homo sapiens (Human) 2839 cell adhesion [GO:0007155] GO:0005576; GO:0005634; GO:0005737; GO:0005783; GO:0005911; GO:0007155 0 0 0 PF00595; O42127 CHOYP_BRAFLDRAFT_99630.9.9 m.62563 sp FGFR3_XENLA 31.667 420 249 13 34 420 329 743 2.20E-48 180 FGFR3_XENLA reviewed Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) fgfr3 Xenopus laevis (African clawed frog) 802 apoptotic process [GO:0006915]; positive regulation of cell proliferation [GO:0008284]; skeletal system development [GO:0001501] GO:0001501; GO:0005007; GO:0005524; GO:0005886; GO:0006915; GO:0008284; GO:0016021 0 0 0 PF07679;PF07714; O46160 CHOYP_RL14.2.9 m.10151 sp RL14_LUMRU 65.714 140 47 1 27 165 5 144 2.20E-60 187 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O75096 CHOYP_LOC578656.5.15 m.23430 sp LRP4_HUMAN 28.982 452 290 12 2 436 606 1043 2.20E-52 198 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; O88488 CHOYP_LOC101063267.1.1 m.14074 sp PTPRQ_RAT 32.117 137 88 3 322 457 295 427 2.20E-09 63.9 PTPRQ_RAT reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1) (rPTP-GMC1) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Ptpgmc1 Rattus norvegicus (Rat) 2302 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0005886; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; O95822 CHOYP_PHUM_PHUM479110.1.1 m.54103 sp DCMC_HUMAN 46.98 447 206 9 75 516 65 485 2.20E-135 404 DCMC_HUMAN reviewed "Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)" MLYCD Homo sapiens (Human) 493 acetyl-CoA biosynthetic process [GO:0006085]; acyl-CoA metabolic process [GO:0006637]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA catabolic process [GO:2001294]; positive regulation of fatty acid oxidation [GO:0046321]; regulation of glucose metabolic process [GO:0010906]; response to ischemia [GO:0002931] GO:0002931; GO:0005102; GO:0005737; GO:0005739; GO:0005759; GO:0005777; GO:0005782; GO:0006085; GO:0006633; GO:0006637; GO:0010906; GO:0046321; GO:0050080; GO:2001294 PATHWAY: Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from malonyl-CoA: step 1/1. 0 0 PF05292; P0C7U4 CHOYP_BRAFLDRAFT_107077.1.1 m.66647 sp C3AR_DANRE 24.765 319 219 10 2 316 35 336 2.20E-14 77 C3AR_DANRE reviewed C3a anaphylatoxin chemotactic receptor (C3AR) (C3a-R) c3ar1 Danio rerio (Zebrafish) (Brachydanio rerio) 361 chemotaxis [GO:0006935] GO:0004930; GO:0005886; GO:0006935; GO:0016021 0 0 0 PF00001; P11678 CHOYP_DYAK_GE13192.2.2 m.43201 sp PERE_HUMAN 34.734 357 210 10 40 386 370 713 2.20E-61 214 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P18460 CHOYP_BRAFLDRAFT_99630.3.9 m.20020 sp FGFR3_CHICK 32.178 404 230 14 870 1241 363 754 2.20E-45 180 FGFR3_CHICK reviewed Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (Tyrosine kinase receptor CEK2) FGFR3 CEK2 Gallus gallus (Chicken) 806 apoptotic process [GO:0006915]; positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0005886; GO:0006915; GO:0008284; GO:0016021 0 0 0 PF07679;PF00047;PF07714; P23403 CHOYP_LOC100199161.1.1 m.20684 sp RS20_XENLA 81.356 118 20 1 3 118 2 119 2.20E-65 196 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P29314 CHOYP_RS9.4.13 m.31864 sp RS9_RAT 93.452 168 11 0 10 177 10 177 2.20E-109 317 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P35555 CHOYP_BRAFLDRAFT_98740.6.7 m.59351 sp FBN1_HUMAN 39.692 325 141 15 179 461 1125 1436 2.20E-44 171 FBN1_HUMAN reviewed Fibrillin-1 [Cleaved into: Asprosin] FBN1 FBN Homo sapiens (Human) 2871 activation of protein kinase A activity [GO:0034199]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; protein kinase A signaling [GO:0010737]; regulation of cellular response to growth factor stimulus [GO:0090287]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501] GO:0001501; GO:0001527; GO:0001656; GO:0005178; GO:0005179; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0005604; GO:0005615; GO:0005622; GO:0006006; GO:0007507; GO:0008201; GO:0010737; GO:0022617; GO:0030023; GO:0030198; GO:0031012; GO:0032403; GO:0033627; GO:0034199; GO:0035582; GO:0035583; GO:0042593; GO:0043010; GO:0045671; GO:0048048; GO:0048050; GO:0070062; GO:0071560; GO:0090287; GO:1990314; GO:2001205 0 0 0 PF12662;PF07645;PF00683; P49286 CHOYP_LOC100377933.1.1 m.24712 sp MTR1B_HUMAN 25 308 220 7 12 313 20 322 2.20E-25 108 MTR1B_HUMAN reviewed Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor) MTNR1B Homo sapiens (Human) 362 "camera-type eye development [GO:0043010]; cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; circadian rhythm [GO:0007623]; glucose homeostasis [GO:0042593]; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cGMP metabolic process [GO:0030824]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; negative regulation of insulin secretion [GO:0046676]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transmission of nerve impulse [GO:0051970]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of transmission of nerve impulse [GO:0051971]; positive regulation of vasodilation [GO:0045909]; regulation of insulin secretion [GO:0050796]; regulation of neuronal action potential [GO:0098908]" GO:0004930; GO:0005829; GO:0005886; GO:0005887; GO:0007166; GO:0007187; GO:0007268; GO:0007623; GO:0008502; GO:0030824; GO:0042593; GO:0043010; GO:0043524; GO:0045909; GO:0046010; GO:0046676; GO:0050796; GO:0051481; GO:0051970; GO:0051971; GO:0098908; GO:1902260 0 0 0 PF00001; P55040 CHOYP_RGK1.2.2 m.31953 sp GEM_HUMAN 34.659 176 104 3 146 312 76 249 2.20E-23 101 GEM_HUMAN reviewed GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) GEM KIR Homo sapiens (Human) 296 cell surface receptor signaling pathway [GO:0007166]; chromosome organization [GO:0051276]; immune response [GO:0006955]; metaphase plate congression [GO:0051310]; mitotic nuclear division [GO:0007067]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264] GO:0000287; GO:0003924; GO:0005525; GO:0005634; GO:0006955; GO:0007067; GO:0007165; GO:0007166; GO:0007264; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686 0 0 0 PF00071; Q13002 CHOYP_LOC100533315.3.3 m.43363 sp GRIK2_HUMAN 37.967 482 256 14 4 464 369 828 2.20E-88 291 GRIK2_HUMAN reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Excitatory amino acid receptor 4) (EAA4) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 GLUR6 Homo sapiens (Human) 908 "behavioral fear response [GO:0001662]; cellular calcium ion homeostasis [GO:0006874]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; inhibitory postsynaptic potential [GO:0060080]; intracellular protein transport [GO:0006886]; modulation of synaptic transmission [GO:0050804]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuronal action potential [GO:0019228]; neuron apoptotic process [GO:0051402]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of JNK cascade [GO:0046328]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic transmission, glutamatergic [GO:0035249]; transport [GO:0006810]" GO:0001662; GO:0005234; GO:0005886; GO:0005887; GO:0006810; GO:0006874; GO:0006886; GO:0007215; GO:0007268; GO:0014069; GO:0015276; GO:0015277; GO:0019228; GO:0030054; GO:0032839; GO:0032983; GO:0035249; GO:0042734; GO:0043113; GO:0043195; GO:0043204; GO:0043524; GO:0043525; GO:0045211; GO:0046328; GO:0048169; GO:0048172; GO:0050804; GO:0050806; GO:0051402; GO:0051967; GO:0060079; GO:0060080 0 0 0 PF01094;PF00060;PF10613; Q14432 CHOYP_PDE3A.1.3 m.22256 sp PDE3A_HUMAN 48.128 561 248 14 447 987 575 1112 2.20E-152 485 PDE3A_HUMAN reviewed "cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)" PDE3A Homo sapiens (Human) 1141 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP-mediated signaling [GO:0019934]; diterpenoid metabolic process [GO:0016101]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of vascular permeability [GO:0043116]; oocyte maturation [GO:0001556]; positive regulation of oocyte development [GO:0060282]; positive regulation of vascular permeability [GO:0043117]; regulation of meiotic nuclear division [GO:0040020]; response to cAMP [GO:0051591]; response to drug [GO:0042493] GO:0001556; GO:0004115; GO:0004119; GO:0005829; GO:0006198; GO:0006629; GO:0016021; GO:0016101; GO:0019933; GO:0019934; GO:0030552; GO:0040020; GO:0042493; GO:0043066; GO:0043116; GO:0043117; GO:0046872; GO:0047555; GO:0051591; GO:0060282; GO:0071321; GO:0071560 0 0 0 PF00233; Q22438 CHOYP_RM51.1.1 m.12099 sp RM51_CAEEL 34.513 113 69 2 106 213 73 185 2.20E-14 72 RM51_CAEEL reviewed "39S ribosomal protein L51, mitochondrial (L51mt) (MRP-L51)" mrpl-51 T12G3.5 Caenorhabditis elegans 199 mitochondrial translation [GO:0032543]; translation [GO:0006412] GO:0003735; GO:0005761; GO:0005762; GO:0006412; GO:0032543 0 0 0 PF10244; Q25145 CHOYP_TPM.12.19 m.40918 sp TPM_HALRU 79.225 284 59 0 1 284 1 284 2.20E-146 414 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q3T075 CHOYP_LOC100372200.1.1 m.43126 sp STX8_BOVIN 45.622 217 113 3 1 214 1 215 2.20E-52 172 STX8_BOVIN reviewed Syntaxin-8 STX8 Bos taurus (Bovine) 236 early endosome to late endosome transport [GO:0045022]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000149; GO:0005484; GO:0005769; GO:0005770; GO:0005802; GO:0005829; GO:0006886; GO:0006906; GO:0012505; GO:0016021; GO:0019869; GO:0031201; GO:0031982; GO:0045022; GO:0048278; GO:0048471; GO:0055037; GO:1903076 0 0 0 PF05739; Q5BIR5 CHOYP_SERPINB3.1.2 m.42514 sp SPB8_BOVIN 40.267 375 213 7 15 381 3 374 2.20E-90 280 SPB8_BOVIN reviewed Serpin B8 SERPINB8 Bos taurus (Bovine) 374 0 GO:0004867; GO:0005615; GO:0005737; GO:0005829; GO:0070062 0 0 0 PF00079; Q5F478 CHOYP_LOC589750.3.5 m.42967 sp ANR44_CHICK 23.58 1039 651 29 737 1735 11 946 2.20E-47 189 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5RBS5 CHOYP_ISCW_ISCW010150.2.2 m.48552 sp BOREA_PONAB 29.365 252 139 7 2 247 3 221 2.20E-11 66.6 BOREA_PONAB reviewed Borealin (Cell division cycle-associated protein 8) CDCA8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 280 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0000775; GO:0005730; GO:0005737; GO:0005819; GO:0007067; GO:0032133; GO:0043234; GO:0051301 0 0 0 PF10512;PF10444; Q5UNS9 CHOYP_contig_025639 m.29255 sp COLL7_MIMIV 42.466 365 167 3 46 368 647 1010 2.20E-55 199 COLL7_MIMIV reviewed Collagen-like protein 7 MIMI_L669 Acanthamoeba polyphaga mimivirus (APMV) 1937 0 GO:0019012 0 0 0 PF01391; Q5ZJB4 CHOYP_IKKA.4.6 m.41952 sp IKKA_CHICK 49.571 466 229 3 10 471 27 490 2.20E-156 465 IKKA_CHICK reviewed Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) CHUK IKKA RCJMB04_19h23 Gallus gallus (Chicken) 759 cellular response to tumor necrosis factor [GO:0071356]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0008384; GO:0042803; GO:0045944; GO:0046982; GO:0071356 0 0 0 PF12179;PF00069; Q65YR7 CHOYP_CPIB.3.3 m.46138 sp CYTA2_DICDI 48 100 43 4 27 124 3 95 2.20E-18 77 CYTA2_DICDI reviewed Cystatin-A2 cpiB DDB_G0280439 Dictyostelium discoideum (Slime mold) 95 proteolysis [GO:0006508] GO:0004869; GO:0005829; GO:0006508 0 0 0 PF00031; Q6GN29 CHOYP_ATLA3.2.2 m.4203 sp ATLA2_XENLA 38.013 463 269 6 13 474 50 495 2.20E-107 333 ATLA2_XENLA reviewed Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) atl2 arl6ip2 Xenopus laevis (African clawed frog) 569 endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0007029; GO:0007030; GO:0016021; GO:0042802; GO:0051260 0 0 0 PF02263;PF02841; Q6SP97 CHOYP_LOC578858.2.2 m.25157 sp ENKUR_MOUSE 48.016 252 125 2 52 303 9 254 2.20E-79 244 ENKUR_MOUSE reviewed Enkurin Enkur Mus musculus (Mouse) 255 0 GO:0001669; GO:0005516; GO:0097228 0 0 0 PF13864; Q6V0I7 CHOYP_BRAFLDRAFT_64071.26.35 m.35564 sp FAT4_HUMAN 32.11 109 48 3 3637 3719 3867 3975 2.20E-08 64.7 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q7T3H9 CHOYP_LOC590729.1.1 m.35260 sp HYI_DANRE 51.711 263 123 2 26 284 4 266 2.20E-97 290 HYI_DANRE reviewed Putative hydroxypyruvate isomerase (EC 5.3.1.22) hyi zgc:63850 Danio rerio (Zebrafish) (Brachydanio rerio) 276 0 GO:0008903 0 0 0 PF01261; Q7ZUV7 CHOYP_RGD1310712.1.1 m.16487 sp EMSY_DANRE 38.675 649 312 21 18 608 4 624 2.20E-78 285 EMSY_DANRE reviewed BRCA2-interacting transcriptional repressor EMSY emsy zgc:56039 Danio rerio (Zebrafish) (Brachydanio rerio) 1173 "covalent chromatin modification [GO:0016569]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006281; GO:0006351; GO:0006355; GO:0016569 0 0 0 PF03735; Q8BIK4 CHOYP_BRAFLDRAFT_119584.1.1 m.15760 sp DOCK9_MOUSE 63.816 152 54 1 14 165 1570 1720 2.20E-61 207 DOCK9_MOUSE reviewed Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) Dock9 D14Wsu89e Kiaa1058 Mus musculus (Mouse) 2055 small GTPase mediated signal transduction [GO:0007264] GO:0005089; GO:0005622; GO:0007264; GO:0012505; GO:0016020; GO:0017048 0 0 0 PF06920;PF14429;PF11878;PF00169; Q8BLF1 CHOYP_BRAFLDRAFT_185672.1.1 m.32341 sp NCEH1_MOUSE 30.402 398 243 11 34 417 17 394 2.20E-51 181 NCEH1_MOUSE reviewed Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Arylacetamide deacetylase-like 1) (Chlorpyrifos oxon-binding protein) (CPO-BP) Nceh1 Aadacl1 Kiaa1363 Mus musculus (Mouse) 408 lipid catabolic process [GO:0016042]; protein dephosphorylation [GO:0006470]; SMAD protein signal transduction [GO:0060395]; xenobiotic metabolic process [GO:0006805] GO:0005783; GO:0006470; GO:0006805; GO:0016020; GO:0016021; GO:0016042; GO:0017171; GO:0042301; GO:0052689; GO:0060395 0 0 0 PF07859; Q8HZY8 CHOYP_LOC100081623.1.1 m.65862 sp CC148_MACFA 35.585 607 378 5 40 646 9 602 2.20E-109 345 CC148_MACFA reviewed Coiled-coil domain-containing protein 148 CCDC148 QflA-10778 QtsA-12190 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 603 0 0 0 0 0 0 Q8IV33 CHOYP_LOC100890552.2.2 m.45669 sp K0825_HUMAN 25.301 166 122 2 27 192 14 177 2.20E-08 57.4 K0825_HUMAN reviewed Uncharacterized protein KIAA0825 KIAA0825 C5orf36 Homo sapiens (Human) 1275 0 0 0 0 0 PF14906; Q8K385 CHOYP_FRRS1.1.3 m.28940 sp FRRS1_MOUSE 34.337 166 97 5 9 171 11 167 2.20E-18 88.2 FRRS1_MOUSE reviewed Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 Sdfr2 Sdr2 Mus musculus (Mouse) 592 0 GO:0000293; GO:0016021; GO:0046872 0 0 cd08544; PF03351;PF02014; Q8N6T3 CHOYP_BRAFLDRAFT_123642.1.2 m.1024 sp ARFG1_HUMAN 41.77 486 190 13 1 473 1 406 2.20E-108 332 ARFG1_HUMAN reviewed ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) ARFGAP1 ARF1GAP Homo sapiens (Human) 406 "ER to Golgi vesicle-mediated transport [GO:0006888]; IRE1-mediated unfolded protein response [GO:0036498]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005096; GO:0005829; GO:0006888; GO:0006890; GO:0015031; GO:0030100; GO:0036498; GO:0045202; GO:0046872 0 0 0 PF01412; Q92859 CHOYP_DCC.1.1 m.11041 sp NEO1_HUMAN 22.35 349 233 12 10 350 426 744 2.20E-09 62.8 NEO1_HUMAN reviewed Neogenin (Immunoglobulin superfamily DCC subclass member 2) NEO1 IGDCC2 NGN Homo sapiens (Human) 1461 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; iron ion homeostasis [GO:0055072]; positive regulation of BMP signaling pathway [GO:0030513] GO:0004872; GO:0005654; GO:0005794; GO:0005886; GO:0005887; GO:0007155; GO:0007411; GO:0030513; GO:0039706; GO:0055072; GO:0098797 0 0 0 PF00041;PF07679;PF13895;PF06583; Q95J53 CHOYP_LOC100370504.2.2 m.62470 sp BTBDG_MACFA 36.695 466 252 6 203 665 79 504 2.20E-93 301 BTBDG_MACFA reviewed BTB/POZ domain-containing protein 16 BTBD16 QnpA-11731 QtsA-17449 QtsA-17837 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 504 0 0 0 0 0 0 Q96LT4 CHOYP_NEMVEDRAFT_V1G184324.1.1 m.48368 sp SAMD8_HUMAN 34.615 416 256 7 1 402 1 414 2.20E-86 272 SAMD8_HUMAN reviewed Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8) SAMD8 Homo sapiens (Human) 415 ceramide biosynthetic process [GO:0046513]; regulation of ceramide biosynthetic process [GO:2000303]; sphingomyelin biosynthetic process [GO:0006686] GO:0006686; GO:0016021; GO:0016740; GO:0030176; GO:0046513; GO:2000303 0 0 0 PF14360;PF00536; Q98943 CHOYP_BRAFLDRAFT_287672.1.1 m.37466 sp CASP2_CHICK 23.867 331 159 9 17 335 170 419 2.20E-14 77 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q99M80 CHOYP_LOC763793.7.7 m.60638 sp PTPRT_MOUSE 31.4 707 434 18 774 1442 760 1453 2.20E-81 298 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BYG5 CHOYP_LOC100888467.1.1 m.8772 sp PAR6B_HUMAN 38.889 90 43 3 1097 1176 168 255 2.20E-06 55.1 PAR6B_HUMAN reviewed Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) PARD6B PAR6B Homo sapiens (Human) 372 axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell-cell junction assembly [GO:0007043]; cell cycle [GO:0007049]; cell division [GO:0051301]; establishment or maintenance of cell polarity [GO:0007163]; protein complex assembly [GO:0006461]; regulation of cell migration [GO:0030334] GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005923; GO:0005938; GO:0006461; GO:0007043; GO:0007049; GO:0007163; GO:0007409; GO:0030334; GO:0043234; GO:0045177; GO:0051301; GO:0070062; GO:0070830 0 0 0 PF00564;PF00595; Q9HC56 CHOYP_BRAFLDRAFT_73233.1.2 m.6275 sp PCDH9_HUMAN 31.701 776 496 17 1 762 6 761 2.20E-97 336 PCDH9_HUMAN reviewed Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0030426; GO:0030900; GO:0044291 0 0 0 PF00028;PF08266;PF08374; Q9NRG9 CHOYP_AAAS.3.3 m.60583 sp AAAS_HUMAN 42.857 91 50 1 23 111 426 516 2.20E-18 82.4 AAAS_HUMAN reviewed Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) 546 fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; learning [GO:0007612]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of nucleocytoplasmic transport [GO:0046822]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005813; GO:0006406; GO:0006409; GO:0006913; GO:0007077; GO:0007612; GO:0009566; GO:0010827; GO:0015031; GO:0016020; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031965; GO:0046822; GO:0075733; GO:1900034 0 0 0 PF00400; Q9NVG8 CHOYP_TBC13.1.1 m.24396 sp TBC13_HUMAN 57.789 398 155 6 24 411 3 397 2.20E-164 470 TBC13_HUMAN reviewed TBC1 domain family member 13 TBC1D13 Homo sapiens (Human) 400 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF00566; Q9ULJ7 CHOYP_LOC578974.9.11 m.53914 sp ANR50_HUMAN 31.561 583 361 21 877 1429 496 1070 2.20E-44 180 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VZW5 CHOYP_TRFR.2.3 m.56049 sp FMAR_DROME 27.907 301 188 10 67 355 117 400 2.20E-18 90.5 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; A4IHY1 CHOYP_BRAFLDRAFT_81733.1.1 m.213 sp PSMG1_XENTR 32.753 287 179 4 5 277 1 287 2.21E-43 152 PSMG1_XENTR reviewed Proteasome assembly chaperone 1 psmg1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 287 proteasome assembly [GO:0043248]; proteasome core complex assembly [GO:0080129] GO:0005737; GO:0005783; GO:0043248; GO:0070628; GO:0080129 0 0 0 PF16094; F1LZ52 CHOYP_KLHL7.1.1 m.9444 sp KLHL3_RAT 37.398 123 69 4 117 237 402 518 2.21E-15 78.2 KLHL3_RAT reviewed Kelch-like protein 3 Klhl3 Rattus norvegicus (Rat) 588 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O69060 CHOYP_BRAFLDRAFT_260946.2.2 m.61697 sp HTXA_PSEST 28.824 170 115 2 50 218 68 232 2.21E-13 71.2 HTXA_PSEST reviewed Probable alpha-ketoglutarate-dependent hypophosphite dioxygenase (EC 1.-.-.-) htxA Pseudomonas stutzeri (Pseudomonas perfectomarina) 286 0 GO:0051213 0 0 0 PF05721; O70277 CHOYP_BRAFLDRAFT_87331.3.4 m.32912 sp TRIM3_RAT 26.016 123 87 3 43 162 622 743 2.21E-07 53.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_87295.7.9 m.52757 sp TRIM3_HUMAN 27.068 133 87 4 175 300 614 743 2.21E-07 56.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75594 CHOYP_BRAFLDRAFT_118718.1.1 m.14739 sp PGRP1_HUMAN 47.337 169 83 3 110 277 30 193 2.21E-49 164 PGRP1_HUMAN reviewed Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S) PGLYRP1 PGLYRP PGRP TNFSF3L SBBI68 UNQ639/PRO1269 Homo sapiens (Human) 196 defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; growth of symbiont in host [GO:0044117]; immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; peptidoglycan catabolic process [GO:0009253] GO:0005576; GO:0006955; GO:0008270; GO:0008745; GO:0009253; GO:0016019; GO:0016045; GO:0032689; GO:0032827; GO:0042834; GO:0044117; GO:0045087; GO:0050728; GO:0050830; GO:0070062 0 0 cd06583; PF01510; P42674 CHOYP_LOC752805.2.3 m.26656 sp BP10_PARLI 35.87 460 269 14 1 448 1 446 2.21E-74 247 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P54145 CHOYP_NEMVEDRAFT_V1G158535.1.1 m.65807 sp AMT1_CAEEL 47.403 462 214 8 26 468 23 474 2.21E-133 400 AMT1_CAEEL reviewed Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans 534 ammonium transmembrane transport [GO:0072488]; nitrogen utilization [GO:0019740]; organic cation transport [GO:0015695] GO:0005887; GO:0008519; GO:0015695; GO:0019740; GO:0072488 0 0 0 PF00909; P62752 CHOYP_RL23A.3.6 m.31005 sp RL23A_RAT 80.952 126 24 0 75 200 31 156 2.21E-66 203 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; Q00557 CHOYP_LOC100371830.4.6 m.25343 sp CP1A1_MESAU 30.343 379 238 9 8 366 11 383 2.21E-47 172 CP1A1_MESAU reviewed Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P-450MC) CYP1A1 Mesocricetus auratus (Golden hamster) 524 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q27J81 CHOYP_INF2.2.5 m.11830 sp INF2_HUMAN 45.455 297 161 1 127 423 30 325 2.21E-79 275 INF2_HUMAN reviewed Inverted formin-2 (HBEBP2-binding protein C) INF2 C14orf151 C14orf173 Homo sapiens (Human) 1249 actin cytoskeleton organization [GO:0030036]; regulation of mitochondrial fission [GO:0090140] GO:0030036; GO:0048471; GO:0090140 0 0 0 PF06367;PF06371;PF02181;PF02205; Q2KIR8 CHOYP_LOC101234062.1.1 m.27366 sp TDH_BOVIN 66.667 309 102 1 38 345 54 362 2.21E-154 441 TDH_BOVIN reviewed "L-threonine 3-dehydrogenase, mitochondrial (EC 1.1.1.103)" TDH Bos taurus (Bovine) 373 L-threonine catabolic process to glycine [GO:0019518] GO:0005739; GO:0008743; GO:0019518; GO:0050662 PATHWAY: Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. {ECO:0000305}. 0 0 PF01370; Q3SZE2 CHOYP_LOC100694901.2.3 m.37046 sp PFD1_BOVIN 54.128 109 50 0 12 120 12 120 2.21E-36 123 PFD1_BOVIN reviewed Prefoldin subunit 1 PFDN1 Bos taurus (Bovine) 122 chaperone mediated protein folding independent of cofactor [GO:0051086]; protein folding [GO:0006457] GO:0005829; GO:0006457; GO:0016272; GO:0051086 0 0 0 PF01920; Q3SZW3 CHOYP_LOC582515.1.1 m.18499 sp ARV1_BOVIN 30.962 239 144 5 4 241 20 238 2.21E-36 134 ARV1_BOVIN reviewed Protein ARV1 ARV1 Bos taurus (Bovine) 282 intracellular sterol transport [GO:0032366]; regulation of plasma membrane sterol distribution [GO:0097036]; sphingolipid metabolic process [GO:0006665]; sterol metabolic process [GO:0016125] GO:0005794; GO:0006665; GO:0016021; GO:0016125; GO:0032366; GO:0032541; GO:0097036 0 0 0 PF04161; Q3URS9 CHOYP_BM1_37930.1.1 m.18805 sp CCD51_MOUSE 24.211 285 195 5 50 314 80 363 2.21E-13 73.9 CCD51_MOUSE reviewed Coiled-coil domain-containing protein 51 Ccdc51 Mus musculus (Mouse) 406 0 GO:0005654; GO:0005739; GO:0016021 0 0 0 0 Q4UMH6 CHOYP_ANK3.4.9 m.9035 sp Y381_RICFE 32.479 234 147 5 130 363 900 1122 2.21E-22 105 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q502K3 CHOYP_LOC763941.4.4 m.64212 sp ANR52_DANRE 37.895 190 118 0 111 300 43 232 2.21E-34 136 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q505D1 CHOYP_ISCW_ISCW019933.1.1 m.884 sp ANR28_MOUSE 27.451 255 154 12 86 322 690 931 2.21E-08 61.6 ANR28_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) Ankrd28 Mus musculus (Mouse) 1053 0 GO:0005654 0 0 0 PF00023;PF12796; Q587J7 CHOYP_BRAFLDRAFT_120982.2.2 m.64414 sp TDR12_HUMAN 31.868 637 413 10 16 646 469 1090 2.21E-96 340 TDR12_HUMAN reviewed Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12) TDRD12 ECAT8 Homo sapiens (Human) 1177 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; positive regulation of protein targeting to mitochondrion [GO:1903955]; RNA secondary structure unwinding [GO:0010501]; spermatogenesis [GO:0007283] GO:0003676; GO:0004004; GO:0005524; GO:0007140; GO:0007275; GO:0007283; GO:0009566; GO:0010501; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:1903955; GO:1990923 0 0 0 PF00270;PF00567; Q5PPV5 CHOYP_ZC2HC1A.1.1 m.16228 sp ZC21A_XENLA 39.143 350 174 10 17 364 9 321 2.21E-59 197 ZC21A_XENLA reviewed Zinc finger C2HC domain-containing protein 1A zc2hc1a fam164a Xenopus laevis (African clawed frog) 323 0 GO:0046872 0 0 0 0 Q5SRX1 CHOYP_LOC101164482.1.1 m.44586 sp TM1L2_MOUSE 43.269 520 224 15 1 495 34 507 2.21E-126 380 TM1L2_MOUSE reviewed TOM1-like protein 2 (Target of Myb-like protein 2) Tom1l2 Mus musculus (Mouse) 507 intracellular protein transport [GO:0006886]; negative regulation of mitotic nuclear division [GO:0045839]; signal transduction [GO:0007165] GO:0005622; GO:0006886; GO:0007165; GO:0019901; GO:0030276; GO:0045839; GO:0070062 0 0 0 PF03127;PF00790; Q5ZL05 CHOYP_CRCM1.1.2 m.29 sp CRCM1_CHICK 78.261 92 18 1 39 128 13 104 2.21E-44 148 CRCM1_CHICK reviewed Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A) ORAI1 CRACM1 TMEM142A RCJMB04_8f15 Gallus gallus (Chicken) 226 adaptive immune response [GO:0002250]; positive regulation of calcium ion transport [GO:0051928]; store-operated calcium entry [GO:0002115] GO:0002115; GO:0002250; GO:0005887; GO:0015279; GO:0016020; GO:0051928 0 0 0 PF07856; Q62910 CHOYP_ISCW_ISCW017778.1.1 m.12069 sp SYNJ1_RAT 42.222 270 80 4 1 197 659 925 2.21E-64 218 SYNJ1_RAT reviewed "Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)" Synj1 Rattus norvegicus (Rat) 1574 brain development [GO:0007420]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of gliogenesis [GO:0014015]; positive regulation of receptor-mediated endocytosis [GO:0048260]; response to cytokine [GO:0034097]; response to retinoic acid [GO:0032526]; synaptic vesicle endocytosis [GO:0048488] GO:0000166; GO:0003723; GO:0004439; GO:0005737; GO:0005829; GO:0007420; GO:0008022; GO:0012506; GO:0014015; GO:0017124; GO:0030132; GO:0032403; GO:0032526; GO:0034097; GO:0034595; GO:0043005; GO:0043195; GO:0043234; GO:0046856; GO:0048260; GO:0048488; GO:0097060 0 0 0 PF08952;PF03372;PF02383; Q6DCC6 CHOYP_GTPB6.1.1 m.12855 sp GTPB6_XENLA 44.34 424 227 7 120 538 106 525 2.21E-114 352 GTPB6_XENLA reviewed Putative GTP-binding protein 6 gtpbp6 Xenopus laevis (African clawed frog) 527 0 GO:0005525; GO:0046872 0 0 cd01878; PF16360;PF13167;PF01926; Q6NZN1 CHOYP_LOC100550090.1.1 m.10345 sp PPRC1_MOUSE 51.449 138 62 3 482 617 1506 1640 2.21E-38 156 PPRC1_MOUSE reviewed Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC) Pprc1 Kiaa0595 Mus musculus (Mouse) 1644 "positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0001104; GO:0005634; GO:0006351; GO:0008134; GO:0030374; GO:0044822; GO:0045944; GO:0051091 0 0 0 PF00076; Q6P5D8 CHOYP_BRAFLDRAFT_215756.1.1 m.22967 sp SMHD1_MOUSE 36.193 373 232 5 2 370 1070 1440 2.21E-76 263 SMHD1_MOUSE reviewed Structural maintenance of chromosomes flexible hinge domain-containing protein 1 Smchd1 Kiaa0650 Mus musculus (Mouse) 2007 chromosome organization [GO:0051276]; dosage compensation by inactivation of X chromosome [GO:0009048]; inactivation of X chromosome by DNA methylation [GO:0060821] GO:0000781; GO:0001740; GO:0005524; GO:0009048; GO:0051276; GO:0060821 0 0 0 PF06470; Q6PFY8 CHOYP_TRI45.19.23 m.55172 sp TRI45_MOUSE 25.856 263 157 8 5 246 127 372 2.21E-12 69.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8TEP8 CHOYP_CEP192.2.2 m.63170 sp CE192_HUMAN 26.829 328 180 8 1 271 1612 1936 2.21E-30 123 CE192_HUMAN reviewed Centrosomal protein of 192 kDa (Cep192) CEP192 KIAA1569 PP8407 Homo sapiens (Human) 1941 centrosome duplication [GO:0051298]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of phosphatase activity [GO:0010923]; spindle assembly [GO:0051225] GO:0000086; GO:0000242; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0010923; GO:0019902; GO:0051225; GO:0051298 0 0 0 0 Q8TER0 CHOYP_LOC100890161.1.3 m.5534 sp SNED1_HUMAN 45.578 294 143 3 17 309 26 303 2.21E-71 261 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q96P44 CHOYP_BRAFLDRAFT_240914.2.3 m.29586 sp COLA1_HUMAN 34.416 154 89 3 267 416 37 182 2.21E-17 89 COLA1_HUMAN reviewed Collagen alpha-1(XXI) chain COL21A1 COL1AL FP633 Homo sapiens (Human) 957 0 GO:0005576; GO:0005578; GO:0005581; GO:0005788 0 0 0 PF01391;PF00092; Q99700 CHOYP_LOC100371390.1.1 m.8047 sp ATX2_HUMAN 47.244 254 118 6 32 280 257 499 2.21E-66 245 ATX2_HUMAN reviewed Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein) ATXN2 ATX2 SCA2 TNRC13 Homo sapiens (Human) 1313 cytoplasmic mRNA processing body assembly [GO:0033962]; negative regulation of receptor internalization [GO:0002091]; regulation of cytoplasmic mRNA processing body assembly [GO:0010603]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]; stress granule assembly [GO:0034063] GO:0002091; GO:0003723; GO:0005154; GO:0005654; GO:0005737; GO:0005794; GO:0005802; GO:0005844; GO:0006417; GO:0008022; GO:0010494; GO:0010603; GO:0016020; GO:0016070; GO:0030529; GO:0033962; GO:0034063; GO:0044822; GO:0048471; GO:0050658 0 0 0 PF06741;PF07145;PF14438; Q9C0D0 CHOYP_KDM1A.1.1 m.60230 sp PHAR1_HUMAN 65.089 169 58 1 451 618 412 580 2.21E-58 209 PHAR1_HUMAN reviewed Phosphatase and actin regulator 1 PHACTR1 KIAA1733 RPEL1 Homo sapiens (Human) 580 actin cytoskeleton reorganization [GO:0031532]; actomyosin structure organization [GO:0031032]; cell motility [GO:0048870]; stress fiber assembly [GO:0043149] GO:0003779; GO:0004864; GO:0005634; GO:0005829; GO:0008599; GO:0030054; GO:0031032; GO:0031532; GO:0043149; GO:0045202; GO:0048870 0 0 0 PF02755; Q9CQ40 CHOYP_RM49.1.1 m.1644 sp RM49_MOUSE 37.107 159 97 3 26 183 10 166 2.21E-26 101 RM49_MOUSE reviewed "39S ribosomal protein L49, mitochondrial (L49mt) (MRP-L49)" Mrpl49 Mus musculus (Mouse) 166 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005761; GO:0005762; GO:0006412 0 0 0 PF05046; Q9H3G5 CHOYP_CPVL.2.2 m.62669 sp CPVL_HUMAN 57.007 421 178 1 134 551 38 458 2.21E-174 504 CPVL_HUMAN reviewed "Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)" CPVL VLP PSEC0124 UNQ197/PRO223 Homo sapiens (Human) 476 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004185; GO:0051603; GO:0070062 0 0 0 PF00450; Q9NQW7 CHOYP_XPP1.2.2 m.38696 sp XPP1_HUMAN 45.257 643 311 16 85 716 2 614 2.21E-166 500 XPP1_HUMAN reviewed "Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)" XPNPEP1 XPNPEPL XPNPEPL1 Homo sapiens (Human) 623 bradykinin catabolic process [GO:0010815]; proteolysis [GO:0006508] GO:0004177; GO:0005737; GO:0006508; GO:0010815; GO:0030145; GO:0042803; GO:0070006; GO:0070062 0 0 0 PF01321;PF00557;PF16188; Q9NR99 CHOYP_HMCN1.40.44 m.62607 sp MXRA5_HUMAN 27.674 430 247 19 231 641 1853 2237 2.21E-15 84.7 MXRA5_HUMAN reviewed Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican) MXRA5 Homo sapiens (Human) 2828 0 GO:0070062 0 0 0 PF07679;PF13855; Q9VF08 CHOYP_SMP_168770.1.1 m.18618 sp TIM16_DROME 56.303 119 52 0 44 162 3 121 2.21E-43 143 TIM16_DROME reviewed Mitochondrial import inner membrane translocase subunit Tim16 (Protein black pearl) blp CG5268 Drosophila melanogaster (Fruit fly) 141 embryonic development via the syncytial blastoderm [GO:0001700]; instar larval development [GO:0002168]; neurogenesis [GO:0022008]; protein import into mitochondrial matrix [GO:0030150] GO:0001700; GO:0002168; GO:0005744; GO:0022008; GO:0030150 0 0 0 0 Q9VHI4 CHOYP_SF3B5.1.1 m.12205 sp SF3B5_DROME 88.235 85 10 0 39 123 1 85 2.21E-53 165 SF3B5_DROME reviewed Probable splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit) CG11985 Drosophila melanogaster (Fruit fly) 85 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0005689; GO:0007052; GO:0071011 0 0 0 PF07189; Q9Y2M2 CHOYP_LOC585129.1.1 m.36079 sp SSUH2_HUMAN 33.232 328 200 5 65 387 39 352 2.21E-59 199 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 A2AX52 CHOYP_LOC100709262.2.2 m.61237 sp CO6A4_MOUSE 35.238 105 64 3 35 139 946 1046 2.22E-11 63.9 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A4IF63 CHOYP_BRAFLDRAFT_220493.3.3 m.43011 sp TRIM2_BOVIN 26.712 146 93 4 9 150 609 744 2.22E-10 60.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5PMU4 CHOYP_ANS1B.1.1 m.46724 sp ANS1B_DANRE 37.331 517 262 12 1095 1589 727 1203 2.22E-90 326 ANS1B_DANRE reviewed Ankyrin repeat and sterile alpha motif domain-containing protein 1B anks1b si:ch211-211o1.2 si:dkey-11k24.3 Danio rerio (Zebrafish) (Brachydanio rerio) 1280 regulation of synaptic plasticity by receptor localization to synapse [GO:1900383] GO:0005737; GO:1900383 0 0 0 PF12796;PF00640;PF00536;PF07647; D8VNT0 CHOYP_BRAFLDRAFT_86061.9.13 m.50942 sp FCNV4_CERRY 47.907 215 105 5 87 298 128 338 2.22E-63 206 FCNV4_CERRY reviewed Ryncolin-4 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; E1C231 CHOYP_LTN1.2.2 m.15852 sp LTN1_CHICK 57.5 120 49 2 8 126 4 122 2.22E-38 141 LTN1_CHICK reviewed E3 ubiquitin-protein ligase listerin (EC 6.3.2.-) (RING finger protein 160) (Zfp-294) LTN1 RNF160 Gallus gallus (Chicken) 1766 protein autoubiquitination [GO:0051865] GO:0008270; GO:0016874; GO:0051865; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; O75179 CHOYP_LOC581927.19.27 m.48541 sp ANR17_HUMAN 32.866 499 309 16 175 650 222 717 2.22E-51 196 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O93310 CHOYP_LOC100376067.3.3 m.62990 sp RAD21_XENLA 51.329 489 189 9 1 474 1 455 2.22E-143 434 RAD21_XENLA reviewed Double-strand-break repair protein rad21 homolog (SCC1 homolog) rad21 Xenopus laevis (African clawed frog) 629 apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168] GO:0000228; GO:0000775; GO:0006281; GO:0006915; GO:0007059; GO:0007067; GO:0051301; GO:0071168 0 0 0 PF04824;PF04825; P00504 CHOYP_BRAFLDRAFT_124686.1.1 m.18409 sp AATC_CHICK 55.122 410 179 1 30 434 3 412 2.22E-177 504 AATC_CHICK reviewed "Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)" GOT1 Gallus gallus (Chicken) 412 2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate metabolic process [GO:0006531]; cellular amino acid metabolic process [GO:0006520]; gluconeogenesis [GO:0006094]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114] GO:0004069; GO:0005829; GO:0006094; GO:0006103; GO:0006114; GO:0006520; GO:0006531; GO:0006532; GO:0006536; GO:0030170; GO:0042802; GO:0047801; GO:0080130 0 0 0 PF00155; P08953 CHOYP_AAEL_AAEL000057.1.1 m.36013 sp TOLL_DROME 24.866 374 232 22 47 384 563 923 2.22E-07 57.4 TOLL_DROME reviewed Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) 1097 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cell adhesion [GO:0007155]; defense response [GO:0006952]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; dorsal/ventral axis specification [GO:0009950]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; mitotic cytokinesis [GO:0000281]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; regulation of hemocyte differentiation [GO:0045610]; regulation of melanization defense response [GO:0035007]; response to bacterium [GO:0009617]; response to fungus [GO:0009620]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]; zygotic specification of dorsal/ventral axis [GO:0007352] GO:0000281; GO:0002229; GO:0004888; GO:0005737; GO:0005769; GO:0005886; GO:0006952; GO:0006955; GO:0006963; GO:0006967; GO:0007155; GO:0007352; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009617; GO:0009620; GO:0009880; GO:0009897; GO:0009950; GO:0009986; GO:0016021; GO:0016201; GO:0019730; GO:0019732; GO:0019955; GO:0030097; GO:0032154; GO:0035007; GO:0035172; GO:0042802; GO:0043234; GO:0045087; GO:0045610; GO:0045944; GO:0050830; GO:0050832; GO:0070976; GO:1902875 0 0 0 PF00560;PF13306;PF13855;PF01462;PF01582; P09487 CHOYP_LOC101158849.1.1 m.11861 sp PPBT_BOVIN 49.064 481 222 8 34 503 29 497 2.22E-156 458 PPBT_BOVIN reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) 524 biomineral tissue development [GO:0031214]; cellular response to organic cyclic compound [GO:0071407]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; osteoblast differentiation [GO:0001649]; response to antibiotic [GO:0046677]; response to vitamin D [GO:0033280] GO:0001649; GO:0001958; GO:0003006; GO:0004035; GO:0005578; GO:0005886; GO:0016462; GO:0031214; GO:0031225; GO:0033280; GO:0046677; GO:0046872; GO:0065010; GO:0070062; GO:0071407 0 0 0 PF00245; P10610 CHOYP_CYP2A13.1.1 m.1314 sp CP2G1_RAT 38.495 465 267 4 17 465 24 485 2.22E-111 342 CP2G1_RAT reviewed Cytochrome P450 2G1 (EC 1.14.14.1) (CYPIIG1) (Cytochrome P450 olfactive) (Cytochrome P450-OLF1) Cyp2g1 Cyp2g-1 Rattus norvegicus (Rat) 494 epoxygenase P450 pathway [GO:0019373]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608] GO:0004497; GO:0005506; GO:0005789; GO:0007608; GO:0008392; GO:0008395; GO:0019373; GO:0020037; GO:0031090; GO:0050896; GO:0070330 0 0 0 PF00067; P23772 CHOYP_GATA2.1.2 m.1656 sp GATA3_MOUSE 50.606 330 101 11 48 340 62 366 2.22E-83 267 GATA3_MOUSE reviewed Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3) Gata3 Gata-3 Mus musculus (Mouse) 443 "anatomical structure formation involved in morphogenesis [GO:0048646]; aortic valve morphogenesis [GO:0003180]; axon guidance [GO:0007411]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cardiac right ventricle morphogenesis [GO:0003215]; cell activation [GO:0001775]; cell fate determination [GO:0001709]; cell maturation [GO:0048469]; cell morphogenesis [GO:0000902]; cellular response to BMP stimulus [GO:0071773]; cellular response to cytokine stimulus [GO:0071345]; cellular response to interferon-alpha [GO:0035457]; cellular response to interleukin-4 [GO:0071353]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; developmental growth [GO:0048589]; digestive tract development [GO:0048565]; ear development [GO:0043583]; embryonic hemopoiesis [GO:0035162]; embryonic organ development [GO:0048568]; erythrocyte differentiation [GO:0030218]; homeostasis of number of cells [GO:0048872]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; inner ear morphogenesis [GO:0042472]; interferon-gamma secretion [GO:0072643]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lymphocyte migration [GO:0072676]; male gonad development [GO:0008584]; mast cell differentiation [GO:0060374]; mesenchymal to epithelial transition [GO:0060231]; mesonephros development [GO:0001823]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell motility [GO:2000146]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell proliferation involved in mesonephros development [GO:2000607]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [GO:2000703]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [GO:2000734]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nephric duct formation [GO:0072179]; nephric duct morphogenesis [GO:0072178]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; norepinephrine biosynthetic process [GO:0042421]; otic vesicle development [GO:0071599]; parathyroid gland development [GO:0060017]; parathyroid hormone secretion [GO:0035898]; pharyngeal system development [GO:0060037]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cytokine production [GO:0001819]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-13 secretion [GO:2000667]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-5 secretion [GO:2000664]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of signal transduction [GO:0009967]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of ureteric bud formation [GO:0072107]; post-embryonic development [GO:0009791]; pro-T cell differentiation [GO:0002572]; regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043370]; regulation of cellular response to X-ray [GO:2000683]; regulation of cytokine biosynthetic process [GO:0042035]; regulation of establishment of cell polarity [GO:2000114]; regulation of histone H3-K27 methylation [GO:0061085]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of nephron tubule epithelial cell differentiation [GO:0072182]; regulation of neuron apoptotic process [GO:0043523]; regulation of neuron projection development [GO:0010975]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; renal system development [GO:0072001]; response to drug [GO:0042493]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to virus [GO:0009615]; signal transduction [GO:0007165]; sympathetic nervous system development [GO:0048485]; T cell differentiation [GO:0030217]; T cell differentiation in thymus [GO:0033077]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell differentiation [GO:0045064]; thymic T cell selection [GO:0045061]; thymus development [GO:0048538]; TOR signaling [GO:0031929]; type IV hypersensitivity [GO:0001806]; ureteric bud formation [GO:0060676]; ureter maturation [GO:0035799]; uterus development [GO:0060065]; ventricular septum development [GO:0003281]" GO:0000122; GO:0000790; GO:0000902; GO:0000976; GO:0000977; GO:0000979; GO:0000987; GO:0001046; GO:0001077; GO:0001078; GO:0001085; GO:0001158; GO:0001701; GO:0001709; GO:0001764; GO:0001775; GO:0001806; GO:0001819; GO:0001822; GO:0001823; GO:0002088; GO:0002572; GO:0003180; GO:0003215; GO:0003281; GO:0003682; GO:0003700; GO:0003713; GO:0005134; GO:0005634; GO:0005667; GO:0005730; GO:0006338; GO:0006357; GO:0006959; GO:0007165; GO:0007399; GO:0007411; GO:0008134; GO:0008270; GO:0008285; GO:0008584; GO:0009615; GO:0009791; GO:0009967; GO:0010332; GO:0010595; GO:0010628; GO:0010629; GO:0010975; GO:0014065; GO:0030182; GO:0030217; GO:0030218; GO:0031929; GO:0032689; GO:0032703; GO:0032736; GO:0032753; GO:0032754; GO:0033077; GO:0033600; GO:0035162; GO:0035457; GO:0035799; GO:0035898; GO:0042035; GO:0042421; GO:0042472; GO:0042493; GO:0043370; GO:0043523; GO:0043565; GO:0043583; GO:0043627; GO:0044212; GO:0045061; GO:0045064; GO:0045087; GO:0045471; GO:0045582; GO:0045597; GO:0045599; GO:0045786; GO:0045892; GO:0045893; GO:0045944; GO:0046983; GO:0048469; GO:0048485; GO:0048538; GO:0048565; GO:0048568; GO:0048589; GO:0048646; GO:0048872; GO:0050728; GO:0050852; GO:0051569; GO:0051897; GO:0060017; GO:0060037; GO:0060065; GO:0060231; GO:0060374; GO:0060676; GO:0061085; GO:0061290; GO:0070888; GO:0071345; GO:0071353; GO:0071356; GO:0071442; GO:0071599; GO:0071773; GO:0071837; GO:0072001; GO:0072107; GO:0072178; GO:0072179; GO:0072182; GO:0072602; GO:0072643; GO:0072676; GO:1901536; GO:2000114; GO:2000146; GO:2000352; GO:2000553; GO:2000607; GO:2000611; GO:2000617; GO:2000664; GO:2000667; GO:2000679; GO:2000683; GO:2000703; GO:2000734 0 0 0 PF00320; P28024 CHOYP_LOC101069759.1.1 m.40708 sp PSB4_XENLA 59.35 246 91 1 27 272 6 242 2.22E-110 321 PSB4_XENLA reviewed Proteasome subunit beta type-4 (EC 3.4.25.1) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (Fragment) psmb4 Xenopus laevis (African clawed frog) 242 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0051603 0 0 cd03760; PF00227; P41824 CHOYP_LOC100370246.1.2 m.14614 sp YBOXH_APLCA 66.406 128 26 2 27 144 1 121 2.22E-48 164 YBOXH_APLCA reviewed Y-box factor homolog (APY1) 0 Aplysia californica (California sea hare) 253 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355 0 0 cd04458; PF00313; P55016 CHOYP_S12A1.1.1 m.27930 sp S12A1_RAT 41.071 112 54 2 5 106 942 1051 2.22E-17 79.3 S12A1_RAT reviewed Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter) Slc12a1 Nkcc2 Rattus norvegicus (Rat) 1095 chloride transport [GO:0006821]; diterpenoid metabolic process [GO:0016101]; ion transmembrane transport [GO:0034220]; potassium ion transport [GO:0006813]; protein insertion into membrane from inner side [GO:0032978]; renal rubidium ion absorption [GO:0035829]; renal sodium ion absorption [GO:0070294]; sodium ion transport [GO:0006814] GO:0005886; GO:0006813; GO:0006814; GO:0006821; GO:0008511; GO:0009986; GO:0016021; GO:0016101; GO:0016324; GO:0032978; GO:0034220; GO:0035827; GO:0035829; GO:0070294 0 0 0 PF00324;PF08403;PF03522; P90689 CHOYP_ACT2.1.3 m.10932 sp ACT_BRUMA 92.857 126 2 1 1 126 1 119 2.22E-81 246 ACT_BRUMA reviewed Actin 0 Brugia malayi (Filarial nematode worm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q09PK2 CHOYP_LOC764850.1.8 m.5397 sp APRV1_MOUSE 27.885 104 73 1 2 103 207 310 2.22E-07 50.8 APRV1_MOUSE reviewed Retroviral-like aspartic protease 1 (EC 3.4.23.-) (Skin-specific retroviral-like aspartic protease) (SASPase) (Skin aspartic protease) (TPA-inducible aspartic proteinase-like protein) Asprv1 Sasp Taps Mus musculus (Mouse) 339 protein processing [GO:0016485]; skin development [GO:0043588] GO:0004190; GO:0016021; GO:0016485; GO:0043588 0 0 0 0 Q20681 CHOYP_CRE_09504.1.1 m.55535 sp BAT38_CAEEL 41.935 93 52 2 24 115 230 321 2.22E-11 63.5 BAT38_CAEEL reviewed BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans 387 0 0 0 0 0 PF00651;PF00917; Q24K15 CHOYP_BRAFLDRAFT_59661.5.6 m.60646 sp ANGP4_BOVIN 40.991 222 121 6 93 311 281 495 2.22E-55 190 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q2TAL6 CHOYP_VWC2.3.3 m.63045 sp VWC2_HUMAN 33.333 99 61 2 30 128 219 312 2.22E-08 54.3 VWC2_HUMAN reviewed Brorin (Brain-specific chordin-like protein) (von Willebrand factor C domain-containing protein 2) VWC2 UNQ739/PRO1434 Homo sapiens (Human) 325 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666] GO:0005604; GO:0005614; GO:0005615; GO:0010811; GO:0030054; GO:0030514; GO:0032281; GO:0045202; GO:0045666 0 0 0 PF00093; Q5REY7 CHOYP_UBXN7.1.1 m.64349 sp UBXN7_PONAB 42.105 513 239 12 23 512 11 488 2.22E-134 401 UBXN7_PONAB reviewed UBX domain-containing protein 7 UBXN7 UBXD7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 489 0 GO:0005654; GO:0034098 0 0 0 PF00789; Q5RJ80 CHOYP_LOC101165018.3.5 m.40568 sp CAPR2_DANRE 32.727 165 84 6 240 386 756 911 2.22E-11 69.3 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5U5M8 CHOYP_ISCW_ISCW004420.8.8 m.65213 sp BL1S3_MOUSE 28.877 187 112 5 7 182 13 189 2.22E-09 58.2 BL1S3_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) (Reduced pigmentation protein) Bloc1s3 Blos3 Rp Mus musculus (Mouse) 195 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to drug [GO:0042493]; secretion of lysosomal enzymes [GO:0033299] GO:0001654; GO:0005737; GO:0005829; GO:0007596; GO:0008089; GO:0008320; GO:0016197; GO:0030133; GO:0030168; GO:0031083; GO:0031175; GO:0032402; GO:0032438; GO:0032816; GO:0033299; GO:0035646; GO:0042493; GO:0043473; GO:0048066; GO:0048490; GO:0060155; GO:1904115 0 0 0 PF15753; Q68FQ4 CHOYP_CK070.1.1 m.65576 sp CK070_RAT 53.543 254 116 1 28 279 12 265 2.22E-94 282 CK070_RAT reviewed Uncharacterized protein C11orf70 homolog 0 Rattus norvegicus (Rat) 267 0 0 0 0 0 PF14926; Q8LGG8 CHOYP_LOC100180855.2.4 m.46097 sp USPAL_ARATH 28.261 138 87 5 14 141 27 162 2.22E-11 61.6 USPAL_ARATH reviewed Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) 175 response to stress [GO:0006950] GO:0005886; GO:0006950; GO:0016208 0 0 0 PF00582; Q8N695 CHOYP_SC5A8.1.2 m.27223 sp SC5A8_HUMAN 31.559 263 164 8 7 258 322 579 2.22E-25 108 SC5A8_HUMAN reviewed Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) 610 apoptotic process [GO:0006915]; ion transport [GO:0006811]; sodium ion transport [GO:0006814] GO:0005886; GO:0005887; GO:0006811; GO:0006814; GO:0006915; GO:0008028; GO:0015293; GO:0016324; GO:0022803; GO:0070062 0 0 0 PF00474; Q8NEN9 CHOYP_PDZD8.1.1 m.47045 sp PDZD8_HUMAN 23.933 539 282 16 30 538 693 1133 2.22E-24 112 PDZD8_HUMAN reviewed PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) PDZD8 PDZK8 Homo sapiens (Human) 1154 cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; regulation of cell morphogenesis [GO:0022604]; viral process [GO:0016032] GO:0005622; GO:0007010; GO:0016020; GO:0016032; GO:0022604; GO:0035556; GO:0046872 0 0 0 PF00130;PF00595; Q8WWT9 CHOYP_S13A2.1.2 m.3753 sp S13A3_HUMAN 38.278 418 234 8 1 402 113 522 2.22E-82 266 S13A3_HUMAN reviewed Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) SLC13A3 NADC3 SDCT2 Homo sapiens (Human) 602 citrate transport [GO:0015746] GO:0005886; GO:0005887; GO:0015137; GO:0015141; GO:0015183; GO:0015362; GO:0015746; GO:0017153; GO:0070062 0 0 0 PF00939; Q96I34 CHOYP_LOC581083.1.1 m.18507 sp PP16A_HUMAN 54.294 326 136 3 1 321 1 318 2.22E-116 363 PP16A_HUMAN reviewed Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase-targeting subunit 3) PPP1R16A MYPT3 Homo sapiens (Human) 528 0 GO:0005886; GO:0008599 0 0 0 PF12796; Q96RW7 CHOYP_BRAFLDRAFT_68242.1.3 m.4413 sp HMCN1_HUMAN 44.898 343 186 3 26 368 4524 4863 2.22E-91 321 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BVQ7 CHOYP_BRAFLDRAFT_90046.1.1 m.13688 sp SPA5L_HUMAN 51.663 511 235 5 95 603 231 731 2.22E-178 527 SPA5L_HUMAN reviewed Spermatogenesis-associated protein 5-like protein 1 SPATA5L1 Homo sapiens (Human) 753 0 GO:0005524; GO:0005737 0 0 0 PF00004; Q9VCU9 CHOYP_DICER.3.3 m.33335 sp DCR1_DROME 28.041 592 348 18 6 536 45 619 2.22E-49 188 DCR1_DROME reviewed Endoribonuclease Dcr-1 (Protein dicer-1) (EC 3.1.26.-) Dcr-1 CG4792 Drosophila melanogaster (Fruit fly) 2249 "apoptotic DNA fragmentation [GO:0006309]; dendrite morphogenesis [GO:0048813]; dsRNA transport [GO:0033227]; germarium-derived female germ-line cyst formation [GO:0030727]; germarium-derived oocyte fate determination [GO:0007294]; germ-line stem cell division [GO:0042078]; mitotic cell cycle, embryonic [GO:0045448]; pole cell formation [GO:0007279]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; production of siRNA involved in RNA interference [GO:0030422]; response to starvation [GO:0042594]; RNA interference [GO:0016246]; segment polarity determination [GO:0007367]; siRNA loading onto RISC involved in RNA interference [GO:0035087]" GO:0003725; GO:0003727; GO:0004386; GO:0004525; GO:0004530; GO:0005524; GO:0005737; GO:0006309; GO:0007279; GO:0007294; GO:0007367; GO:0016246; GO:0016442; GO:0016443; GO:0030422; GO:0030727; GO:0031054; GO:0033227; GO:0035087; GO:0035196; GO:0042078; GO:0042594; GO:0045448; GO:0046872; GO:0048813; GO:0070883 0 0 cd00593; PF03368;PF00271;PF02170;PF00636; Q9Y617 CHOYP_BRAFLDRAFT_270672.1.1 m.25768 sp SERC_HUMAN 63.187 364 134 0 34 397 6 369 2.22E-174 494 SERC_HUMAN reviewed Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) PSAT1 PSA Homo sapiens (Human) 370 L-serine biosynthetic process [GO:0006564]; pyridoxine biosynthetic process [GO:0008615] GO:0004648; GO:0005737; GO:0005829; GO:0006564; GO:0008615; GO:0070062 PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.; PATHWAY: Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5. 0 0 PF00266; Q9Z265 CHOYP_LOC100372241.1.1 m.9935 sp CHK2_MOUSE 49.099 444 219 4 95 532 85 527 2.22E-156 461 CHK2_MOUSE reviewed Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Checkpoint kinase 2) Chek2 Chk2 Rad53 Mus musculus (Mouse) 546 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular protein catabolic process [GO:0044257]; cellular response to bisphenol A [GO:1903926]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to drug [GO:0035690]; cellular response to gamma radiation [GO:0071480]; DNA damage induced protein phosphorylation [GO:0006975]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; double-strand break repair [GO:0006302]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic spindle assembly [GO:0090307]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of DNA damage checkpoint [GO:2000002]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of anoikis [GO:2000210]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of protein catabolic process [GO:0042176]; regulation of transcription, DNA-templated [GO:0006355]; replicative cell aging [GO:0001302]; response to doxorubicin [GO:1902520]; response to gamma radiation [GO:0010332]; signal transduction in response to DNA damage [GO:0042770]; signal transduction involved in intra-S DNA damage checkpoint [GO:0072428]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0000781; GO:0001302; GO:0001934; GO:0004672; GO:0004674; GO:0005524; GO:0005654; GO:0005794; GO:0006302; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0006974; GO:0006975; GO:0006978; GO:0008630; GO:0010332; GO:0016605; GO:0018105; GO:0019901; GO:0031625; GO:0035690; GO:0042176; GO:0042770; GO:0042771; GO:0042802; GO:0042803; GO:0044257; GO:0045893; GO:0046777; GO:0046872; GO:0050821; GO:0051301; GO:0071157; GO:0071480; GO:0072428; GO:0090307; GO:1902520; GO:1903926; GO:2000002; GO:2000210 0 0 0 PF00498;PF00069; A4YI89 CHOYP_LOC100556648.1.1 m.54658 sp HPCD_METS5 36.923 195 113 3 46 236 12 200 2.23E-31 120 HPCD_METS5 reviewed 3-hydroxypropionyl-coenzyme A dehydratase (3-hydroxypropionyl-CoA dehydratase) (EC 4.2.1.116) Msed_2001 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 259 fatty acid metabolic process [GO:0006631] GO:0006631; GO:0043956 0 0 0 PF00378; B4JG34 CHOYP_BRAFLDRAFT_124027.1.2 m.22812 sp TMEDE_DROGR 69.159 214 65 1 16 228 3 216 2.23E-114 328 TMEDE_DROGR reviewed Transmembrane emp24 domain-containing protein eca eca GH18190 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) 216 dorsal/ventral pattern formation [GO:0009953]; transport [GO:0006810] GO:0005789; GO:0006810; GO:0009953; GO:0016021 0 0 0 PF01105; D3YXG0 CHOYP_LOC100744578.1.1 m.35392 sp HMCN1_MOUSE 23.741 417 248 17 236 628 4018 4388 2.23E-06 55.8 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O95295 CHOYP_BRAFLDRAFT_118250.1.1 m.11178 sp SNAPN_HUMAN 61.458 96 37 0 35 130 22 117 2.23E-34 119 SNAPN_HUMAN reviewed SNARE-associated protein Snapin (Biogenesis of lysosome-related organelles complex 1 subunit 7) (BLOC-1 subunit 7) (Synaptosomal-associated protein 25-binding protein) (SNAP-associated protein) SNAPIN BLOC1S7 SNAP25BP SNAPAP Homo sapiens (Human) 136 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; melanosome organization [GO:0032438]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; neurotransmitter secretion [GO:0007269]; positive regulation of late endosome to lysosome transport [GO:1902824]; regulation of protein binding [GO:0043393]; synaptic vesicle exocytosis [GO:0016079]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle maturation [GO:0016188]; synaptic vesicle transport [GO:0048489]; terminal button organization [GO:0072553]; viral process [GO:0016032] GO:0000139; GO:0000149; GO:0005730; GO:0005794; GO:0006886; GO:0007269; GO:0008021; GO:0008089; GO:0008333; GO:0010977; GO:0016032; GO:0016079; GO:0016188; GO:0030054; GO:0030141; GO:0030672; GO:0031083; GO:0031175; GO:0031629; GO:0032418; GO:0032438; GO:0043234; GO:0043393; GO:0045202; GO:0048471; GO:0048489; GO:0048490; GO:0072553; GO:0097352; GO:1902824; GO:1904115 0 0 0 PF14712; P08635 CHOYP_OLAH.2.2 m.28730 sp SAST_RAT 40.486 247 145 2 3 249 13 257 2.23E-64 204 SAST_RAT reviewed "S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain-containing protein 1)" Olah Mch Thedc1 Rattus norvegicus (Rat) 263 fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338] GO:0004320; GO:0005829; GO:0006633; GO:0008610; GO:0016295; GO:0016296; GO:0016297; GO:0035338 0 0 0 PF00975; P10155 CHOYP_LOC100634688.1.6 m.20228 sp RO60_HUMAN 46.727 550 271 8 321 865 6 538 2.23E-157 474 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P23953 CHOYP_SASB.3.3 m.51787 sp EST1C_MOUSE 32.867 572 319 21 28 578 11 538 2.23E-77 258 EST1C_MOUSE reviewed Carboxylesterase 1C (EC 3.1.1.1) (Liver carboxylesterase N) (Lung surfactant convertase) (PES-N) Ces1c Es1 Mus musculus (Mouse) 554 0 GO:0005615; GO:0005788; GO:0016788; GO:0052689 0 0 0 PF00135; P62752 CHOYP_LOC100207752.1.1 m.22424 sp RL23A_RAT 76.033 121 29 0 31 151 36 156 2.23E-58 181 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P84875 CHOYP_TFPI1.1.1 m.63070 sp PCPI_SABMA 43.81 105 56 2 32 136 56 157 2.23E-20 85.1 PCPI_SABMA reviewed Carboxypeptidase inhibitor SmCI 0 Sabellastarte magnifica (Feather duster) 165 0 GO:0004867; GO:0008191 0 0 0 PF00014; P98133 CHOYP_BRAFLDRAFT_98740.5.7 m.58200 sp FBN1_BOVIN 39.005 382 205 14 11 379 1084 1450 2.23E-59 211 FBN1_BOVIN reviewed Fibrillin-1 (MP340) [Cleaved into: Asprosin] FBN1 Bos taurus (Bovine) 2871 activation of protein kinase A activity [GO:0034199]; anatomical structure morphogenesis [GO:0009653]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; protein kinase A signaling [GO:0010737]; regulation of cellular response to growth factor stimulus [GO:0090287] GO:0001527; GO:0005179; GO:0005201; GO:0005509; GO:0005576; GO:0005615; GO:0005622; GO:0006006; GO:0008201; GO:0009653; GO:0010737; GO:0034199; GO:0042593; GO:0090287 0 0 0 PF12662;PF07645;PF00683; Q03692 CHOYP_CBLN13.3.9 m.26739 sp COAA1_HUMAN 30.709 127 75 5 58 183 563 677 2.23E-10 62 COAA1_HUMAN reviewed Collagen alpha-1(X) chain COL10A1 Homo sapiens (Human) 680 cartilage development [GO:0051216]; collagen catabolic process [GO:0030574]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; skeletal system development [GO:0001501] GO:0001501; GO:0001958; GO:0005576; GO:0005578; GO:0005581; GO:0005788; GO:0005938; GO:0030198; GO:0030574; GO:0046872; GO:0051216 0 0 0 PF00386;PF01391; Q06396 CHOYP_LOC100637317.4.4 m.55151 sp ARF1_ORYSJ 59.669 181 69 2 1 181 1 177 2.23E-79 237 ARF1_ORYSJ reviewed ADP-ribosylation factor 1 (13 kDa cold-induced protein) Os01g0813400 LOC_Os01g59790 OsJ_03844 OSJNBa0085D07.10 P0425G02.41 P0432B10.14 Oryza sativa subsp. japonica (Rice) 181 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q11002 CHOYP_LOC100166784.1.1 m.53118 sp CANA_DROME 40.404 198 110 5 31 225 59 251 2.23E-38 144 CANA_DROME reviewed Calpain-A (EC 3.4.22.-) (Calcium-activated neutral proteinase A) (CANP A) [Cleaved into: Calpain-A catalytic subunit] CalpA CG7563 Drosophila melanogaster (Fruit fly) 828 BMP signaling pathway involved in spinal cord dorsal/ventral patterning [GO:0021919]; cuticle development [GO:0042335]; defense response to fungus [GO:0050832]; determination of adult lifespan [GO:0008340]; dorsal/ventral pattern formation [GO:0009953]; phagocytosis [GO:0006909]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508] GO:0004198; GO:0005509; GO:0005622; GO:0005737; GO:0006508; GO:0006909; GO:0008340; GO:0009953; GO:0015629; GO:0016540; GO:0021919; GO:0042335; GO:0043025; GO:0050832 0 0 0 PF01067;PF00648; Q15459 CHOYP_SF3A1.3.3 m.57222 sp SF3A1_HUMAN 60 150 56 3 20 167 385 532 2.23E-51 179 SF3A1_HUMAN reviewed Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) SF3A1 SAP114 Homo sapiens (Human) 793 "mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000381; GO:0000389; GO:0000398; GO:0003723; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0006397; GO:0044822; GO:0071004; GO:0071013 0 0 0 PF12230;PF01805;PF00240; Q15643 CHOYP_TRIP11.1.2 m.961 sp TRIPB_HUMAN 34.311 341 197 9 4 327 19 349 2.23E-39 152 TRIPB_HUMAN reviewed Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) 1979 protein targeting to Golgi [GO:0000042]; transcription from RNA polymerase II promoter [GO:0006366]; ventricular septum development [GO:0003281] GO:0000042; GO:0000139; GO:0002079; GO:0002081; GO:0003281; GO:0003713; GO:0005634; GO:0005794; GO:0005801; GO:0005856; GO:0006366; GO:0030133 0 0 0 0 Q16204 CHOYP_CCDC6.1.1 m.13918 sp CCDC6_HUMAN 63.881 371 106 8 1 361 75 427 2.23E-138 405 CCDC6_HUMAN reviewed Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) CCDC6 D10S170 TST1 Homo sapiens (Human) 474 0 GO:0005200; GO:0005737; GO:0005856 0 0 0 PF09755; Q28193 CHOYP_PCSK6.1.1 m.65309 sp FURIN_BOVIN 42.105 57 33 0 89 145 110 166 2.23E-10 61.6 FURIN_BOVIN reviewed Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) (Trans Golgi network protease furin) FURIN FUR PACE Bos taurus (Bovine) 797 protein processing [GO:0016485] GO:0004252; GO:0005615; GO:0005794; GO:0005886; GO:0016021; GO:0016485; GO:0046872 0 0 0 PF01483;PF00082;PF16470; Q40302 CHOYP_CALM.39.50 m.54637 sp CALM_MACPY 55.396 139 61 1 2 140 3 140 2.23E-45 147 CALM_MACPY reviewed Calmodulin (CaM) 0 Macrocystis pyrifera (Giant kelp) (Fucus pyrifer) 149 0 GO:0005509 0 0 0 PF13499; Q40302 CHOYP_LOC100565534.2.3 m.29570 sp CALM_MACPY 60.135 148 59 0 28 175 1 148 2.23E-62 192 CALM_MACPY reviewed Calmodulin (CaM) 0 Macrocystis pyrifera (Giant kelp) (Fucus pyrifer) 149 0 GO:0005509 0 0 0 PF13499; Q5RJ80 CHOYP_SMP_023240.2.3 m.40510 sp CAPR2_DANRE 28.986 138 88 5 35 164 776 911 2.23E-07 52.8 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5T5D7 CHOYP_ZNF382.1.1 m.21527 sp ZN684_HUMAN 37.363 182 109 3 350 530 186 363 2.23E-32 130 ZN684_HUMAN reviewed Zinc finger protein 684 ZNF684 Homo sapiens (Human) 378 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q5U3U0 CHOYP_EEF1A.3.3 m.37430 sp PHYD1_DANRE 23.704 270 157 11 33 269 4 257 2.23E-07 55.5 PHYD1_DANRE reviewed Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC 1.-.-.-) phyhd1 zgc:101639 Danio rerio (Zebrafish) (Brachydanio rerio) 291 0 GO:0046872; GO:0051213 0 0 0 PF05721; Q5ZJQ3 CHOYP_LIN52.2.2 m.29358 sp LIN52_CHICK 70.27 111 30 2 16 125 1 109 2.23E-49 156 LIN52_CHICK reviewed Protein lin-52 homolog LIN52 RCJMB04_16g11 Gallus gallus (Chicken) 112 "cell cycle [GO:0007049]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0007049; GO:0070176 0 0 0 PF10044; Q63ZR5 CHOYP_LOC580747.1.1 m.55831 sp RHN2B_XENLA 44.732 579 304 7 19 590 22 591 2.23E-174 516 RHN2B_XENLA reviewed Rhophilin-2-B (GTP-Rho-binding protein 2-B) rhpn2-b Xenopus laevis (African clawed frog) 683 signal transduction [GO:0007165] GO:0007165; GO:0048471 0 0 0 PF03097;PF02185; Q640U0 CHOYP_ACBD5.2.2 m.26712 sp ACBD5_XENTR 30.223 493 259 13 9 459 7 456 2.23E-53 188 ACBD5_XENTR reviewed Acyl-CoA-binding domain-containing protein 5 acbd5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 458 pexophagy [GO:0030242]; transport [GO:0006810] GO:0000062; GO:0005778; GO:0006810; GO:0008289; GO:0016021; GO:0030242 0 0 0 PF00887; Q6DCF6 CHOYP_EFCB7.1.1 m.34105 sp EFCB7_XENLA 37.598 383 222 10 530 904 245 618 2.23E-75 262 EFCB7_XENLA reviewed EF-hand calcium-binding domain-containing protein 7 efcab7 Xenopus laevis (African clawed frog) 620 0 GO:0005509 0 0 0 PF13202;PF13499; Q6NT16 CHOYP_NEMVEDRAFT_V1G171569.1.1 m.43680 sp S18B1_HUMAN 40.293 273 156 4 77 348 21 287 2.23E-50 177 S18B1_HUMAN reviewed MFS-type transporter SLC18B1 (Solute carrier family 18 member B1) SLC18B1 C6orf192 Homo sapiens (Human) 456 0 GO:0005887; GO:0022857 0 0 cd06174; PF07690; Q6NT55 CHOYP_LOC100379072.1.1 m.43496 sp CP4FN_HUMAN 43.441 465 252 6 48 504 59 520 2.23E-130 392 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q8C190 CHOYP_LOC100367974.3.3 m.61376 sp VP9D1_MOUSE 41.036 251 132 3 468 702 397 647 2.23E-51 192 VP9D1_MOUSE reviewed VPS9 domain-containing protein 1 (5-day ovary-specific transcript 1 protein) Vps9d1 Mus musculus (Mouse) 649 0 0 0 0 0 PF02204; Q8NFT8 CHOYP_LOC100374832.3.5 m.35205 sp DNER_HUMAN 36.735 98 39 3 4730 4804 437 534 2.23E-08 64.7 DNER_HUMAN reviewed Delta and Notch-like epidermal growth factor-related receptor DNER BET UNQ262/PRO299 Homo sapiens (Human) 737 central nervous system development [GO:0007417]; endocytosis [GO:0006897]; glial cell differentiation [GO:0010001]; neuron migration [GO:0001764]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; skeletal muscle fiber development [GO:0048741]; synapse assembly [GO:0007416] GO:0001764; GO:0004888; GO:0005509; GO:0005769; GO:0005886; GO:0006897; GO:0007219; GO:0007220; GO:0007416; GO:0007417; GO:0010001; GO:0016021; GO:0030276; GO:0030425; GO:0043025; GO:0048741 0 0 0 PF00008;PF12661; Q91ZT9 CHOYP_LOC100185060.1.2 m.14546 sp ASB8_MOUSE 39.634 164 92 5 157 318 35 193 2.23E-22 101 ASB8_MOUSE reviewed Ankyrin repeat and SOCS box protein 8 (ASB-8) Asb8 Mus musculus (Mouse) 288 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005737; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q94CF0 CHOYP_BRAFLDRAFT_282105.1.2 m.43460 sp EHD1_ARATH 26.368 201 128 7 89 276 197 390 2.23E-08 60.1 EHD1_ARATH reviewed EH domain-containing protein 1 (AtEHD1) (EC 3.6.5.2) EHD1 At3g20290 MQC12.3 Arabidopsis thaliana (Mouse-ear cress) 545 endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; hyperosmotic salinity response [GO:0042538]; protein homooligomerization [GO:0051260] GO:0005509; GO:0005525; GO:0005737; GO:0005768; GO:0005886; GO:0006897; GO:0009506; GO:0010008; GO:0016020; GO:0016787; GO:0032456; GO:0042538; GO:0043231; GO:0051260 0 0 0 PF00350;PF12763;PF16880; Q99946 CHOYP_LOC100379067.1.4 m.17555 sp PRRT1_HUMAN 50 76 38 0 71 146 219 294 2.23E-18 82.8 PRRT1_HUMAN reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) PRRT1 C6orf31 NG5 Homo sapiens (Human) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q9BXX0 CHOYP_C1QL2.30.32 m.63252 sp EMIL2_HUMAN 31.469 143 83 4 286 415 907 1047 2.23E-07 57 EMIL2_HUMAN reviewed EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) 1053 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030023; GO:0031012 0 0 0 PF00386;PF07546; Q9H222 CHOYP_ABCG8.1.1 m.3707 sp ABCG5_HUMAN 41.573 623 349 6 32 642 26 645 2.23E-165 491 ABCG5_HUMAN reviewed ATP-binding cassette sub-family G member 5 (Sterolin-1) ABCG5 Homo sapiens (Human) 651 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; excretion [GO:0007588]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; response to drug [GO:0042493]; response to ionizing radiation [GO:0010212]; response to nutrient [GO:0007584]; sterol transport [GO:0015918]; transmembrane transport [GO:0055085] GO:0005524; GO:0005886; GO:0007584; GO:0007588; GO:0010212; GO:0010949; GO:0015918; GO:0016324; GO:0017127; GO:0030299; GO:0033344; GO:0042493; GO:0042626; GO:0042632; GO:0043190; GO:0043235; GO:0045796; GO:0046982; GO:0055085 0 0 0 PF01061;PF00005; A7SM54 CHOYP_UFC1.2.2 m.53946 sp UFC1_NEMVE 83.529 170 27 1 1 170 1 169 2.24E-103 296 UFC1_NEMVE reviewed Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) v1g214407 Nematostella vectensis (Starlet sea anemone) 169 0 0 0 0 0 PF08694; B1WB06 CHOYP_LACBIDRAFT_307647.1.1 m.29486 sp MET24_XENTR 29.297 256 156 11 77 316 103 349 2.24E-17 85.1 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; O75347 CHOYP_TBCA.1.1 m.12075 sp TBCA_HUMAN 60.952 105 41 0 26 130 1 105 2.24E-36 123 TBCA_HUMAN reviewed Tubulin-specific chaperone A (TCP1-chaperonin cofactor A) (Tubulin-folding cofactor A) (CFA) TBCA Homo sapiens (Human) 108 post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021] GO:0005730; GO:0005737; GO:0005874; GO:0006457; GO:0007021; GO:0007023; GO:0015630; GO:0044822; GO:0051087; GO:0070062 0 0 0 PF02970; O75897 CHOYP_ST1C4.2.3 m.14628 sp ST1C4_HUMAN 38.628 277 149 8 34 301 37 301 2.24E-51 174 ST1C4_HUMAN reviewed Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) 302 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; sulfation [GO:0051923] GO:0004062; GO:0005829; GO:0008146; GO:0050427; GO:0051923 0 0 0 PF00685; P18700 CHOYP_TBB.3.7 m.42379 sp TBB_STRPU 98.013 151 3 0 26 176 130 280 2.24E-105 326 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P20478 CHOYP_GLNA.1.5 m.1591 sp GLNA2_DROME 69.626 214 63 2 7 219 34 246 2.24E-108 318 GLNA2_DROME reviewed Glutamine synthetase 2 cytoplasmic (EC 6.3.1.2) (Glutamate--ammonia ligase 2) Gs2 CG1743 Drosophila melanogaster (Fruit fly) 369 glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; neurotransmitter receptor metabolic process [GO:0045213]; synapse assembly [GO:0007416] GO:0004356; GO:0005524; GO:0005737; GO:0006538; GO:0006542; GO:0007416; GO:0045213 0 0 0 PF00120;PF03951; P21613 CHOYP_KIF5A.1.1 m.42766 sp KINH_DORPE 38.293 410 140 16 82 408 588 967 2.24E-48 179 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P24781 CHOYP_LOC100204831.1.1 m.7214 sp BRAC_XENLA 40.94 149 86 2 1 149 69 215 2.24E-30 124 BRAC_XENLA reviewed Brachyury protein (xBRA) (Protein T) t bra Xenopus laevis (African clawed frog) 432 "cellular response to fibroblast growth factor stimulus [GO:0044344]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000578; GO:0001102; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007368; GO:0044344; GO:0045893; GO:0045944 0 0 0 PF00907; P28289 CHOYP_LOC100372150.1.1 m.7059 sp TMOD1_HUMAN 44.94 336 178 5 55 385 12 345 2.24E-85 266 TMOD1_HUMAN reviewed Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod) TMOD1 D9S57E TMOD Homo sapiens (Human) 359 actin filament organization [GO:0007015]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694] GO:0003779; GO:0005523; GO:0005634; GO:0005829; GO:0005865; GO:0005884; GO:0006936; GO:0007015; GO:0008344; GO:0016020; GO:0030016; GO:0030017; GO:0030049; GO:0030239; GO:0030863; GO:0051694; GO:0070307 0 0 0 PF03250; P41828 CHOYP_HR3.1.1 m.43893 sp NHR23_CAEEL 47.458 118 58 3 5 119 158 274 2.24E-25 114 NHR23_CAEEL reviewed Nuclear hormone receptor family member nhr-23 (Steroid hormone receptor family member chr-3) nhr-23 chr-3 C01H6.5 Caenorhabditis elegans 588 "molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0018996 0 0 0 PF00104;PF00105; Q06852 CHOYP_SSPO.7.14 m.26549 sp SLAP1_CLOTH 53.926 484 147 40 10 431 1523 1992 2.24E-37 158 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q2YDR3 CHOYP_BRAFLDRAFT_119617.1.1 m.50138 sp IMPA3_DANRE 43.681 364 157 10 2 340 1 341 2.24E-88 272 IMPA3_DANRE reviewed Inositol monophosphatase 3 (IMP 3) (IMPase 3) (EC 3.1.3.25) (Inositol monophosphatase domain-containing protein 1) (Inositol-1(or 4)-monophosphatase 3) (Myo-inositol monophosphatase A3) impad1 impa3 zgc:123256 Danio rerio (Zebrafish) (Brachydanio rerio) 341 inositol biosynthetic process [GO:0006021]; phosphatidylinositol phosphorylation [GO:0046854] GO:0000287; GO:0005737; GO:0006021; GO:0008254; GO:0008934; GO:0016021; GO:0046854; GO:0052832; GO:0052833 PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. 0 0 PF00459; Q3SZ90 CHOYP_ISCW_ISCW019130.1.2 m.10722 sp RL13A_BOVIN 63.317 199 73 0 4 202 3 201 2.24E-92 271 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q494R4 CHOYP_LOC100177979.2.2 m.64471 sp CC153_HUMAN 26.923 208 149 1 26 230 1 208 2.24E-16 78.2 CC153_HUMAN reviewed Coiled-coil domain-containing protein 153 CCDC153 Homo sapiens (Human) 210 0 0 0 0 0 0 Q54WS5 CHOYP_LOC755988.1.1 m.61862 sp ROCO6_DICDI 26.449 276 160 9 408 682 630 863 2.24E-13 78.6 ROCO6_DICDI reviewed Probable serine/threonine-protein kinase roco6 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 6) roco6 DDB_G0279417 Dictyostelium discoideum (Slime mold) 2147 small GTPase mediated signal transduction [GO:0007264] GO:0004674; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0016021 0 0 0 PF16095;PF12799;PF00169;PF07714;PF08477; Q6AYG0 CHOYP_LOC100370823.1.3 m.29976 sp RRNAD_RAT 35.644 101 54 2 2 96 8 103 2.24E-10 59.7 RRNAD_RAT reviewed Protein RRNAD1 Rrnad1 Rattus norvegicus (Rat) 475 0 GO:0016021 0 0 0 PF13679; Q6DIB5 CHOYP_LOC100371242.2.6 m.33843 sp MEG10_MOUSE 35.616 511 257 23 228 691 349 834 2.24E-64 234 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q8BH16 CHOYP_BRAFLDRAFT_73295.1.1 m.62803 sp FBXL2_MOUSE 27.411 394 268 15 92 474 15 401 2.24E-24 108 FBXL2_MOUSE reviewed F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) Fbxl2 Mus musculus (Mouse) 423 protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004842; GO:0006511; GO:0006513; GO:0010506; GO:0014066; GO:0016020; GO:0016567; GO:0019005; GO:0019903; GO:0031146; GO:0036312 0 0 0 PF12937;PF13516; Q8CGF6 CHOYP_LOC410771.1.1 m.1264 sp WDR47_MOUSE 56.647 346 146 2 641 982 571 916 2.24E-127 412 WDR47_MOUSE reviewed WD repeat-containing protein 47 (Neuronal enriched MAP interacting protein) (Nemitin) Wdr47 Kiaa0893 Mus musculus (Mouse) 920 multicellular organism development [GO:0007275] GO:0005737; GO:0005874; GO:0007275 0 0 0 PF12894;PF00400; Q8K4C0 CHOYP_FMO5.2.6 m.11476 sp FMO5_RAT 52.11 474 218 5 1 467 27 498 2.24E-176 509 FMO5_RAT reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) Fmo5 Rattus norvegicus (Rat) 533 drug metabolic process [GO:0017144] GO:0004499; GO:0005789; GO:0016021; GO:0017144; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; Q91ZA8 CHOYP_NRARP.1.1 m.7175 sp NRARP_MOUSE 59.14 93 37 1 10 101 13 105 2.24E-34 117 NRARP_MOUSE reviewed Notch-regulated ankyrin repeat-containing protein Nrarp Mus musculus (Mouse) 114 blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Notch signaling pathway involved in somitogenesis [GO:1902367]; negative regulation of T cell differentiation [GO:0045581]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; patterning of blood vessels [GO:0001569]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of cell-cell adhesion [GO:0022407]; somite rostral/caudal axis specification [GO:0032525]; sprouting angiogenesis [GO:0002040] GO:0000122; GO:0001569; GO:0001938; GO:0002040; GO:0002043; GO:0007219; GO:0022407; GO:0032525; GO:0045581; GO:0045746; GO:0060828; GO:0090263; GO:1902367 0 0 0 PF12796; Q96DM1 CHOYP_LOC100877580.1.1 m.24591 sp PGBD4_HUMAN 30.588 170 110 3 7 171 105 271 2.24E-16 79.3 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9H251 CHOYP_CDHR2.3.3 m.47139 sp CAD23_HUMAN 30.915 896 542 27 97 976 87 921 2.24E-83 306 CAD23_HUMAN reviewed Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) 3354 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0005509; GO:0005886; GO:0006816; GO:0007156; GO:0007601; GO:0007605; GO:0007626; GO:0016020; GO:0016021; GO:0016339; GO:0032420; GO:0045494; GO:0050896; GO:0050953; GO:0050957; GO:0051480; GO:0060122 0 0 0 PF00028; Q9H2P9 CHOYP_LOC577892.1.2 m.523 sp DPH5_HUMAN 68.421 190 59 1 2 191 61 249 2.24E-98 289 DPH5_HUMAN reviewed Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase) DPH5 AD-018 CGI-30 HSPC143 NPD015 Homo sapiens (Human) 285 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183] GO:0004164; GO:0005829; GO:0017183 PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. 0 cd11647; PF00590; Q9HBH5 CHOYP_LOC100373300.1.1 m.1536 sp RDH14_HUMAN 42.424 297 151 5 39 316 39 334 2.24E-71 227 RDH14_HUMAN reviewed Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4) RDH14 PAN2 SDR7C4 UNQ529/PRO1072 Homo sapiens (Human) 336 osteoblast differentiation [GO:0001649] GO:0001649; GO:0005634; GO:0005739; GO:0005765; GO:0005783; GO:0005789; GO:0016020; GO:0016491; GO:0052650 0 0 0 PF00106; Q9I919 CHOYP_LOC581835.1.1 m.49601 sp GPR85_DANRE 31.111 360 231 8 36 382 11 366 2.24E-55 189 GPR85_DANRE reviewed Probable G protein-coupled receptor 85 (Super conserved receptor expressed in brain 2) (zSREB2) gpr85 sreb2 si:dkey-223l3.1 Danio rerio (Zebrafish) (Brachydanio rerio) 371 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q9LDH0 CHOYP_LOC100843487.1.1 m.10483 sp XYLT_ARATH 24.552 391 211 11 139 453 124 506 2.24E-24 109 XYLT_ARATH reviewed "Beta-(1,2)-xylosyltransferase (EC 2.4.2.38)" XYLT At5g55500 MTE17.21 Arabidopsis thaliana (Mouse-ear cress) 534 "posttranslational protein targeting to membrane, translocation [GO:0031204]; protein N-linked glycosylation [GO:0006487]" GO:0000139; GO:0005794; GO:0005797; GO:0006487; GO:0016021; GO:0031204; GO:0032580; GO:0042285; GO:0050513 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04577; Q9NYG2 CHOYP_BRAFLDRAFT_223325.1.1 m.65937 sp ZDHC3_HUMAN 40 255 135 5 13 257 38 284 2.24E-52 175 ZDHC3_HUMAN reviewed Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Protein DHHC1) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) ZDHHC3 HSD49 Homo sapiens (Human) 299 protein palmitoylation [GO:0018345]; protein targeting [GO:0006605] GO:0000139; GO:0005794; GO:0006605; GO:0008270; GO:0016020; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q9UA35 CHOYP_SLC28A3.1.1 m.39295 sp S28A3_EPTST 41.03 641 320 12 23 644 7 608 2.24E-150 453 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; Q9UGM3 CHOYP_DMBT1.30.34 m.58281 sp DMBT1_HUMAN 39.164 766 331 16 2 638 251 1010 2.24E-146 473 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UHF1 CHOYP_LOC100635497.2.3 m.13708 sp EGFL7_HUMAN 31.405 121 62 5 696 808 69 176 2.24E-07 57 EGFL7_HUMAN reviewed Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1) EGFL7 MEGF7 UNQ187/PRO1449 Homo sapiens (Human) 273 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001938; GO:0005509; GO:0005576; GO:0005615; GO:0007155; GO:0031012; GO:0045746 0 0 0 PF07974;PF07645;PF07546; Q9UKK3 CHOYP_LOC100373327.3.13 m.20106 sp PARP4_HUMAN 48.061 593 298 6 3 587 621 1211 2.24E-171 563 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9VBW3 CHOYP_CBS.2.2 m.65897 sp CAD96_DROME 35.855 304 186 2 434 734 461 758 2.24E-60 221 CAD96_DROME reviewed Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14) Cad96Ca HD-14 CG10244 Drosophila melanogaster (Fruit fly) 773 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; Golgi organization [GO:0007030]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell size [GO:0045792]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; wound healing [GO:0042060] GO:0004672; GO:0004713; GO:0004714; GO:0005509; GO:0005524; GO:0005887; GO:0006468; GO:0007030; GO:0007156; GO:0016339; GO:0042060; GO:0045177; GO:0045792; GO:0090303 0 0 0 PF07714; Q9Y5X5 CHOYP_NPFFR2.1.1 m.25584 sp NPFF2_HUMAN 34.304 309 175 6 46 339 154 449 2.24E-50 180 NPFF2_HUMAN reviewed Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) 522 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; detection of abiotic stimulus [GO:0009582]; G-protein coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase activity [GO:0045761]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of MAPK cascade [GO:0043408]; response to peptide [GO:1901652] GO:0004930; GO:0005886; GO:0005887; GO:0007186; GO:0007268; GO:0008188; GO:0009582; GO:0015629; GO:0032870; GO:0042277; GO:0043408; GO:0045761; GO:1901652; GO:2000479 0 0 0 PF00001; A4IF63 CHOYP_BRAFLDRAFT_84664.2.7 m.3973 sp TRIM2_BOVIN 27.642 123 84 4 322 439 622 744 2.25E-06 53.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B3EWY9 CHOYP_LOC100639936.1.1 m.3485 sp MLP_ACRMI 27.224 1113 639 36 400 1443 355 1365 2.25E-100 362 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B9EKR1 CHOYP_PTPREA.2.2 m.64169 sp PRPTZ_MOUSE 35.874 538 310 17 621 1129 1750 2281 2.25E-84 305 PRPTZ_MOUSE reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) Ptprz1 Mus musculus (Mouse) 2312 axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; hematopoietic progenitor cell differentiation [GO:0002244]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0002244; GO:0004725; GO:0005578; GO:0005615; GO:0005737; GO:0007409; GO:0007413; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0016021; GO:0021766; GO:0030027; GO:0030175; GO:0030424; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; G5EFI8 CHOYP_ISCW_ISCW009315.1.1 m.48416 sp PLCE1_CAEEL 33.168 404 255 6 1 391 164 565 2.25E-59 214 PLCE1_CAEEL reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-epsilon plc-1) (Phosphoinositide-specific phospholipase PLC210) (Phospholipase C-epsilon plc-1) (PLC-epsilon plc-1)" plc-1 F31B12.1 Caenorhabditis elegans 1898 "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process [GO:1902634]; negative regulation of adenylate cyclase activity [GO:0007194]; small GTPase mediated signal transduction [GO:0007264]" GO:0004435; GO:0004871; GO:0005085; GO:0005622; GO:0007194; GO:0007264; GO:0017016; GO:1902634 0 0 0 PF00168;PF09279;PF00388;PF00387;PF00788;PF00617; O16305 CHOYP_CALM.32.50 m.48894 sp CALM_CAEEL 95.302 149 7 0 1 149 1 149 2.25E-100 287 CALM_CAEEL reviewed Calmodulin (CaM) cmd-1 T21H3.3 Caenorhabditis elegans 149 apoptotic cell clearance [GO:0043277]; cell migration [GO:0016477]; embryo development ending in birth or egg hatching [GO:0009792]; establishment of meiotic spindle orientation [GO:0051296]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of protein localization [GO:0032880] GO:0005509; GO:0005813; GO:0009792; GO:0016477; GO:0031965; GO:0032880; GO:0042981; GO:0043277; GO:0051296; GO:0051726; GO:0071944; GO:0072686 0 0 0 PF13499; O42249 CHOYP_GBLP.5.7 m.41212 sp GBLP_ORENI 88.119 101 12 0 1 101 217 317 2.25E-62 194 GBLP_ORENI reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 317 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:2000114; GO:2000543 0 0 0 PF00400; O75382 CHOYP_BRAFLDRAFT_79377.23.30 m.59052 sp TRIM3_HUMAN 25.346 217 149 7 169 379 535 744 2.25E-08 59.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75899 CHOYP_LOC100378348.1.1 m.55794 sp GABR2_HUMAN 30.749 374 226 7 2 352 473 836 2.25E-50 190 GABR2_HUMAN reviewed Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) GABBR2 GPR51 GPRC3B Homo sapiens (Human) 941 chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid signaling pathway [GO:0007214]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of adenylate cyclase activity [GO:0007194] GO:0004965; GO:0005737; GO:0005886; GO:0005887; GO:0007186; GO:0007194; GO:0007214; GO:0007268; GO:0030054; GO:0038039; GO:0043005; GO:0045211 0 0 0 PF00003;PF01094; O95613 CHOYP_LOC582174.2.16 m.16430 sp PCNT_HUMAN 28.321 971 590 25 4481 5414 2402 3303 2.25E-66 256 PCNT_HUMAN reviewed Pericentrin (Kendrin) (Pericentrin-B) PCNT KIAA0402 PCNT2 Homo sapiens (Human) 3336 cilium assembly [GO:0042384]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316] GO:0000086; GO:0000226; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0005874; GO:0007052; GO:0016020; GO:0034451; GO:0042384; GO:0090316 0 0 0 PF10495; P02637 CHOYP_SCP.9.12 m.62606 sp SCP_MIZYE 51.977 177 82 3 2 177 2 176 2.25E-59 186 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P24524 CHOYP_LOC100533289.6.6 m.59221 sp GLRA3_RAT 43.609 399 179 8 62 416 55 451 2.25E-106 325 GLRA3_RAT reviewed Glycine receptor subunit alpha-3 Glra3 Rattus norvegicus (Rat) 464 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; neuropeptide signaling pathway [GO:0007218]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0007218; GO:0016594; GO:0016934; GO:0016935; GO:0022852; GO:0030054; GO:0030425; GO:0043204; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; P51798 CHOYP_CLCN7.1.3 m.35948 sp CLCN7_HUMAN 54.762 126 54 2 2 125 673 797 2.25E-38 140 CLCN7_HUMAN reviewed H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) CLCN7 Homo sapiens (Human) 805 ion transmembrane transport [GO:0034220]; response to pH [GO:0009268]; transport [GO:0006810] GO:0005247; GO:0005254; GO:0005524; GO:0005765; GO:0006810; GO:0009268; GO:0015297; GO:0016020; GO:0016021; GO:0031404; GO:0031410; GO:0034220 0 0 0 PF00571;PF00654; P62282 CHOYP_RPS11.2.5 m.21119 sp RS11_RAT 80.833 120 23 0 6 125 31 150 2.25E-71 214 RS11_RAT reviewed 40S ribosomal protein S11 Rps11 Rattus norvegicus (Rat) 158 osteoblast differentiation [GO:0001649]; translation [GO:0006412] GO:0001649; GO:0003735; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022627; GO:0044822; GO:0070062 0 0 0 PF00366;PF16205; P84675 CHOYP_CGB_G5180C.1.1 m.55203 sp PFM_CHAGB 33.333 216 122 10 50 248 5 215 2.25E-27 107 PFM_CHAGB reviewed Putative fungistatic metabolite CHGG_05463 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) 222 defense response to fungus [GO:0050832]; killing of cells of other organism [GO:0031640] GO:0031640; GO:0050832 0 0 0 PF01822; Q09654 CHOYP_NEMVEDRAFT_V1G205140.1.1 m.53319 sp TRI23_CAEEL 28.144 167 98 8 25 169 118 284 2.25E-07 52.8 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q09YN5 CHOYP_LOC100369767.3.4 m.54780 sp MET_RABIT 39.623 106 62 1 24 129 1258 1361 2.25E-23 97.4 MET_RABIT reviewed Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Oryctolagus cuniculus (Rabbit) 1382 branching morphogenesis of an epithelial tube [GO:0048754]; endothelial cell morphogenesis [GO:0001886]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; semaphorin-plexin signaling pathway [GO:0071526]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001886; GO:0004714; GO:0005524; GO:0007169; GO:0009925; GO:0009986; GO:0016021; GO:0045944; GO:0048754; GO:0050918; GO:0071526; GO:1901299; GO:2001028 0 0 0 PF07714;PF01403;PF01833; Q1PRL4 CHOYP_BRAFLDRAFT_87272.4.6 m.42027 sp LIN41_CHICK 32.911 79 38 2 42 118 771 836 2.25E-06 48.5 LIN41_CHICK reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) 876 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q3KPU6 CHOYP_BRAFLDRAFT_120860.1.1 m.48634 sp CC172_XENLA 25.306 245 183 0 4 248 2 246 2.25E-07 54.3 CC172_XENLA reviewed Coiled-coil domain-containing protein 172 ccdc172 Xenopus laevis (African clawed frog) 256 0 0 0 0 0 0 Q53G44 CHOYP_LOC100377780.3.11 m.38738 sp IF44L_HUMAN 45.349 172 91 2 240 409 176 346 2.25E-37 144 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5G268 CHOYP_LOC591683.1.1 m.46449 sp NETR_NOMLE 51.02 147 71 1 50 196 280 425 2.25E-42 154 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5VX52 CHOYP_LOC100374267.3.5 m.41504 sp SPAT1_HUMAN 43.243 111 63 0 19 129 6 116 2.25E-22 102 SPAT1_HUMAN reviewed Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2) SPATA1 Homo sapiens (Human) 437 0 0 0 0 0 PF15743; Q5ZJQ8 CHOYP_ISCW_ISCW023764.1.1 m.10717 sp UBAC2_CHICK 35.53 349 217 6 1 346 1 344 2.25E-61 202 UBAC2_CHICK reviewed Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1) UBAC2 PHGDHL1 RCJMB04_16f18 Gallus gallus (Chicken) 344 "negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein localization to endoplasmic reticulum [GO:0070972]" GO:0005789; GO:0016021; GO:0070972; GO:1904153 0 0 0 PF00627; Q68CP4 CHOYP_LOC100900363.1.1 m.30664 sp HGNAT_HUMAN 45.118 297 146 5 1 289 376 663 2.25E-79 256 HGNAT_HUMAN reviewed Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) HGSNAT TMEM76 Homo sapiens (Human) 663 glycosaminoglycan catabolic process [GO:0006027]; lysosomal transport [GO:0007041]; protein oligomerization [GO:0051259] GO:0005765; GO:0006027; GO:0007041; GO:0015019; GO:0016021; GO:0016746; GO:0051259 0 0 0 PF07786; Q6DDJ3 CHOYP_DFI8A.1.1 m.28916 sp DFI8A_XENLA 48.961 433 212 3 137 569 10 433 2.25E-147 434 DFI8A_XENLA reviewed Differentially expressed in FDCP 8 homolog A (DEF-8-A) def8-a Xenopus laevis (African clawed frog) 443 intracellular signal transduction [GO:0035556] GO:0005622; GO:0035556; GO:0046872 0 0 0 PF00130;PF13901; Q6R7E1 CHOYP_Y088.1.1 m.30273 sp Y088_OSHVF 23.106 264 158 9 4 251 322 556 2.25E-06 52.4 Y088_OSHVF reviewed Putative transmembrane protein ORF88 ORF88 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 748 0 GO:0016021; GO:0033644 0 0 0 0 Q6ZRF8 CHOYP_BRAFLDRAFT_221115.1.1 m.28513 sp RN207_HUMAN 26.667 150 95 6 68 215 103 239 2.25E-08 57 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8BV79 CHOYP_TRNK1.4.6 m.58601 sp TRNK1_MOUSE 22.535 568 359 21 323 850 2289 2815 2.25E-14 82.4 TRNK1_MOUSE reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1) Trank1 Gm187 Kiaa0342 Lba1 Mus musculus (Mouse) 2999 0 0 0 0 0 0 Q8CGC6 CHOYP_LOC100703956.1.1 m.31550 sp RBM28_MOUSE 38.265 196 96 4 239 413 115 306 2.25E-24 110 RBM28_MOUSE reviewed RNA-binding protein 28 (RNA-binding motif protein 28) Rbm28 Mus musculus (Mouse) 750 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0005681; GO:0005730; GO:0006397; GO:0008380; GO:0044822 0 0 0 PF00076; Q964D9 CHOYP_LOC100533357.1.2 m.56849 sp ACTC_PLATR 65.438 217 30 3 6 221 17 189 2.25E-89 272 ACTC_PLATR reviewed "Actin, cytoplasmic" 0 Planorbella trivolvis (Marsh rams-horn) (Helisoma trivolvis) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96RW7 CHOYP_BRAFLDRAFT_85664.7.10 m.31076 sp HMCN1_HUMAN 44.178 292 155 4 227 516 4584 4869 2.25E-76 268 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99N34 CHOYP_BRAFLDRAFT_229336.1.1 m.57191 sp DFFB_RAT 37.7 313 180 5 17 325 9 310 2.25E-67 218 DFFB_RAT reviewed DNA fragmentation factor subunit beta (EC 3.-.-.-) (Caspase-activated deoxyribonuclease) (CAD) (Caspase-activated DNase) (DNA fragmentation factor 40 kDa subunit) (DFF-40) Dffb Cad Rattus norvegicus (Rat) 349 apoptotic DNA fragmentation [GO:0006309]; brain development [GO:0007420] GO:0000790; GO:0004536; GO:0005634; GO:0005737; GO:0006309; GO:0007420 0 0 0 PF02017;PF09230; Q9BQS2 CHOYP_LOC580697.1.1 m.26865 sp SYT15_HUMAN 44.444 99 55 0 15 113 317 415 2.25E-26 103 SYT15_HUMAN reviewed Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV) SYT15 Homo sapiens (Human) 421 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019905; GO:0030276; GO:0048791; GO:0098793 0 0 0 PF00168; Q9BRZ2 CHOYP_TRI33.1.8 m.4161 sp TRI56_HUMAN 27.57 214 122 6 3 200 1 197 2.25E-15 80.9 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9IBG7 CHOYP_KCP.8.13 m.40457 sp KCP_XENLA 28.109 402 167 22 20 305 728 1123 2.25E-14 77.4 KCP_XENLA reviewed Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) 2327 0 GO:0005576 0 0 0 PF00093;PF00094; Q9JIR0 CHOYP_RIMB1.3.5 m.39097 sp RIMB1_RAT 31.707 820 460 19 20 799 314 1073 2.25E-103 356 RIMB1_RAT reviewed Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) Tspoap1 Bzrap1 Rbp1 Rattus norvegicus (Rat) 1847 0 GO:0005737; GO:0005739; GO:0030156 0 0 0 PF07653;PF14604; Q9JLC8 CHOYP_NEMVEDRAFT_V1G247395.1.8 m.5020 sp SACS_MOUSE 25 820 516 27 123 885 3409 4186 2.25E-44 178 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; A2I7N2 CHOYP_LOC100712102.1.1 m.8433 sp SPA36_BOVIN 39.173 411 238 8 14 420 10 412 2.26E-91 285 SPA36_BOVIN reviewed Serpin A3-6 SERPINA3-6 Bos taurus (Bovine) 414 0 GO:0004867; GO:0005615; GO:0031410; GO:0042583 0 0 0 PF00079; B3EWY9 CHOYP_BRAFLDRAFT_129967.4.4 m.64315 sp MLP_ACRMI 29.041 1064 599 40 866 1865 394 1365 2.26E-99 359 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B3EWZ6 CHOYP_LOC100214792.1.1 m.24325 sp MLRP2_ACRMI 25.871 201 127 9 137 319 4702 4898 2.26E-06 53.5 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ6 CHOYP_LOC580670.3.6 m.15598 sp MLRP2_ACRMI 32.275 945 486 39 595 1477 199 1051 2.26E-95 345 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D3ZSI8 CHOYP_LOC663424.2.2 m.58144 sp PI51A_RAT 51.282 468 179 8 1 462 67 491 2.26E-151 445 PI51A_RAT reviewed Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha) Pip5k1a Rattus norvegicus (Rat) 546 actin cytoskeleton reorganization [GO:0031532]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; phospholipid biosynthetic process [GO:0008654]; protein targeting to plasma membrane [GO:0072661]; ruffle assembly [GO:0097178] GO:0005524; GO:0005737; GO:0005847; GO:0005925; GO:0008654; GO:0010761; GO:0016308; GO:0016607; GO:0030027; GO:0031532; GO:0032587; GO:0048041; GO:0060326; GO:0072661; GO:0090630; GO:0097178 0 0 0 PF01504; E1BWM5 CHOYP_BRAFLDRAFT_117725.2.3 m.34676 sp FUND1_CHICK 45.794 107 51 2 6 105 17 123 2.26E-23 92.8 FUND1_CHICK reviewed FUN14 domain-containing protein 1 FUNDC1 Gallus gallus (Chicken) 156 mitophagy [GO:0000422]; response to hypoxia [GO:0001666] GO:0000422; GO:0001666; GO:0031307 0 0 0 PF04930; H2A0N4 CHOYP_PIF.4.6 m.41949 sp PIF_PINMG 24.638 276 169 12 39 287 274 537 2.26E-13 74.3 PIF_PINMG reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada margaritifera (Black-lipped pearl oyster) 1014 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607;PF00092; O17320 CHOYP_ACT.11.27 m.37947 sp ACT_CRAGI 100 88 0 0 18 105 274 361 2.26E-58 186 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O57592 CHOYP_LOC100214352.1.1 m.20247 sp RL7A_TAKRU 71.308 237 68 0 34 270 25 261 2.26E-126 362 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O60287 CHOYP_URB1.2.3 m.14565 sp NPA1P_HUMAN 36.91 466 275 5 344 796 1430 1889 2.26E-88 318 NPA1P_HUMAN reviewed Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) URB1 C21orf108 KIAA0539 NOP254 NPA1 Homo sapiens (Human) 2271 0 GO:0005730; GO:0044822 0 0 0 PF16201;PF11707; O75208 CHOYP_LOC100376454.1.2 m.29446 sp COQ9_HUMAN 45.026 191 102 2 81 269 128 317 2.26E-56 186 COQ9_HUMAN reviewed "Ubiquinone biosynthesis protein COQ9, mitochondrial" COQ9 C16orf49 HSPC326 PSEC0129 Homo sapiens (Human) 318 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; ubiquinone biosynthetic process [GO:0006744]" GO:0005739; GO:0005743; GO:0006120; GO:0006744; GO:0008289; GO:0042803 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000250|UniProtKB:Q8K1Z0}. 0 0 PF08511; P04323 CHOYP_LOC100892023.1.1 m.31352 sp POL3_DROME 29.167 600 358 13 67 618 216 796 2.26E-72 255 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P0C6X2 CHOYP_SPSINT_2213.1.1 m.61808 sp R1AB_CVHN1 28.387 155 111 0 6 160 952 1106 2.26E-09 63.2 R1AB_CVHN1 reviewed Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (nsp1) (p28); Non-structural protein 2 (nsp2) (p65); Papain-like proteinase (PL-PRO) (EC 3.4.19.12) (EC 3.4.22.69) (Non-structural protein 3) (nsp3) (p210); Non-structural protein 4 (nsp4) (Peptide HD2) (p44); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p27); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7) (p10); Non-structural protein 8 (nsp8) (p22); Non-structural protein 9 (nsp9) (p12); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p15); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p67); Guanine-N7 methyltransferase (ExoN) (EC 2.1.1.-) (EC 3.1.13.-) (nsp14); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p35); 2'-O-methyltransferase (EC 2.1.1.-) (nsp16)] rep 1a-1b Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) 7182 "induction by virus of catabolism of host mRNA [GO:0039595]; induction by virus of host autophagy [GO:0039520]; modulation by virus of host protein ubiquitination [GO:0039648]; suppression by virus of host ISG15 activity [GO:0039579]; suppression by virus of host NF-kappaB transcription factor activity [GO:0039644]; suppression by virus of host type I interferon-mediated signaling pathway [GO:0039502]; transcription, DNA-templated [GO:0006351]; viral genome replication [GO:0019079]; viral protein processing [GO:0019082]" GO:0003723; GO:0003968; GO:0004197; GO:0004386; GO:0004519; GO:0005524; GO:0006351; GO:0008168; GO:0008242; GO:0008270; GO:0016021; GO:0016896; GO:0019079; GO:0019082; GO:0033644; GO:0036459; GO:0039502; GO:0039520; GO:0039579; GO:0039595; GO:0039644; GO:0039648; GO:0044172; GO:0044220 0 0 0 PF16348;PF06478;PF11963;PF01661;PF16251;PF09401;PF06471;PF06460;PF08716;PF08717;PF08710;PF01831;PF05409;PF00680;PF08715; P10079 CHOYP_LOC100632098.8.13 m.38434 sp FBP1_STRPU 55.556 360 160 0 1 360 198 557 2.26E-123 386 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P17978 CHOYP_BRAFLDRAFT_69764.18.19 m.60869 sp VGB_STAAU 26.147 218 146 8 80 291 89 297 2.26E-07 55.1 VGB_STAAU reviewed Virginiamycin B lyase (EC 4.2.99.-) (Streptogramin B lyase) vgb vgh Staphylococcus aureus 299 antibiotic catabolic process [GO:0017001]; response to antibiotic [GO:0046677] GO:0000287; GO:0016835; GO:0017001; GO:0046677 0 0 0 0 P25782 CHOYP_CATL1.1.1 m.56906 sp CYSP2_HOMAM 40.566 318 166 8 27 323 6 321 2.26E-71 227 CYSP2_HOMAM reviewed Digestive cysteine proteinase 2 (EC 3.4.22.-) LCP2 Homarus americanus (American lobster) 323 0 GO:0008234 0 0 0 PF08246;PF00112; P35543 CHOYP_BRAFLDRAFT_124064.3.6 m.38212 sp SAA3_RABIT 66.667 105 34 1 53 157 19 122 2.26E-46 150 SAA3_RABIT reviewed Serum amyloid A-3 protein SAA3 Oryctolagus cuniculus (Rabbit) 122 acute-phase response [GO:0006953] GO:0006953; GO:0034364 0 0 0 PF00277; P52747 CHOYP_LOC100373981.1.1 m.26001 sp ZN143_HUMAN 85.227 176 26 0 1 176 255 430 2.26E-109 328 ZN143_HUMAN reviewed Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf) ZNF143 SBF STAF Homo sapiens (Human) 638 regulation of transcription from RNA polymerase III promoter [GO:0006359]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0005654; GO:0006357; GO:0006359; GO:0006366; GO:0006383; GO:0042795; GO:0046872 0 0 0 PF00096; P86982 CHOYP_RPC_1864.1.1 m.19056 sp IMSP1_RUDPH 51.064 141 58 3 150 288 8 139 2.26E-37 132 IMSP1_RUDPH reviewed Insoluble matrix shell protein 1 (IMSP1) (Fragment) 0 Ruditapes philippinarum (Japanese littleneck clam) (Venerupis philippinarum) 148 0 GO:0005576 0 0 0 0 Q2M2Z5 CHOYP_KIZ.1.1 m.57618 sp KIZ_HUMAN 37.383 107 67 0 10 116 8 114 2.26E-14 80.5 KIZ_HUMAN reviewed Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) KIZ C20orf19 NCRNA00153 PLK1S1 HT013 Homo sapiens (Human) 673 spindle organization [GO:0007051] GO:0005737; GO:0005813; GO:0007051; GO:0019901; GO:0042995 0 0 0 0 Q3SZJ4 CHOYP_PTGR1.1.1 m.29812 sp PTGR1_BOVIN 52.096 334 147 10 1 327 1 328 2.26E-104 311 PTGR1_BOVIN reviewed Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) PTGR1 LTB4DH Bos taurus (Bovine) 329 0 GO:0005737; GO:0008270; GO:0032440; GO:0036132; GO:0047522 0 0 0 PF00107; Q3ZAV0 CHOYP_BRAFLDRAFT_69750.1.1 m.53020 sp CCD60_RAT 26.279 567 317 22 136 684 44 527 2.26E-36 147 CCD60_RAT reviewed Coiled-coil domain-containing protein 60 Ccdc60 Rattus norvegicus (Rat) 542 0 0 0 0 0 PF15769; Q498K0 CHOYP_LOC100376265.1.4 m.3395 sp GALC_XENLA 38.435 294 172 7 2 292 388 675 2.26E-51 183 GALC_XENLA reviewed Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc Xenopus laevis (African clawed frog) 677 carbohydrate metabolic process [GO:0005975]; galactosylceramide catabolic process [GO:0006683] GO:0004336; GO:0005764; GO:0005975; GO:0006683 0 0 0 PF02057; Q53G44 CHOYP_SI_CH211-197G15.10.1.7 m.1774 sp IF44L_HUMAN 31.973 441 264 9 35 468 24 435 2.26E-55 194 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q55E58 CHOYP_TRIADDRAFT_57945.2.3 m.51968 sp PATS1_DICDI 29.715 737 423 15 24 727 1545 2219 2.26E-84 297 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5JZQ8 CHOYP_BRAFLDRAFT_77474.1.1 m.3138 sp CLN6_CANLF 53.71 283 126 3 35 316 31 309 2.26E-101 303 CLN6_CANLF reviewed Ceroid-lipofuscinosis neuronal protein 6 homolog (Protein CLN6) CLN6 Canis lupus familiaris (Dog) (Canis familiaris) 312 cholesterol metabolic process [GO:0008203]; ganglioside metabolic process [GO:0001573]; glycosaminoglycan metabolic process [GO:0030203]; lysosomal lumen acidification [GO:0007042]; lysosome organization [GO:0007040]; positive regulation of proteolysis [GO:0045862] GO:0001573; GO:0005783; GO:0005788; GO:0005789; GO:0007040; GO:0007042; GO:0008203; GO:0016021; GO:0030203; GO:0042803; GO:0045862 0 0 0 PF15156; Q5R1W4 CHOYP_TBA1.6.9 m.40283 sp TBA1B_PANTR 97.403 154 4 0 1 154 37 190 2.26E-107 317 TBA1B_PANTR reviewed Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] TUBA1B Pan troglodytes (Chimpanzee) 451 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q5RAS8 CHOYP_TRIADDRAFT_60361.1.1 m.44292 sp TM199_PONAB 34.171 199 109 7 1 192 21 204 2.26E-28 108 TM199_PONAB reviewed Transmembrane protein 199 TMEM199 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 208 0 GO:0016021; GO:0030663; GO:0033116 0 0 0 PF11712; Q642C0 CHOYP_LOC100368924.1.1 m.5031 sp DNJC8_RAT 61.603 237 86 3 22 253 16 252 2.26E-92 275 DNJC8_RAT reviewed DnaJ homolog subfamily C member 8 Dnajc8 Rattus norvegicus (Rat) 253 0 0 0 0 cd06257; PF00226; Q6Q899 CHOYP_DDX58.6.9 m.50638 sp DDX58_MOUSE 28.97 932 604 27 22 919 10 917 2.26E-88 305 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q7PCJ9 CHOYP_BRAFLDRAFT_285620.6.6 m.66666 sp SAT2_PIG 29.24 171 108 3 1 161 1 168 2.26E-22 90.9 SAT2_PIG reviewed Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) SAT2 SSAT2 Sus scrofa (Pig) 170 putrescine catabolic process [GO:0009447] GO:0004145; GO:0005737; GO:0009447 PATHWAY: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. 0 0 PF00583; Q7TNF8 CHOYP_RIMB1.5.5 m.66780 sp RIMB1_MOUSE 30.828 918 517 26 374 1253 102 939 2.26E-101 359 RIMB1_MOUSE reviewed Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) Tspoap1 Bzrap1 Kiaa0612 Rbp1 Mus musculus (Mouse) 1846 0 GO:0005737; GO:0005739; GO:0030156 0 0 0 PF07653;PF14604; Q7Z5L3 CHOYP_C1QL2.29.32 m.57357 sp C1QL2_HUMAN 29.545 132 85 3 286 415 160 285 2.26E-07 55.5 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q8IVU1 CHOYP_PHUM_PHUM068980.1.5 m.4066 sp IGDC3_HUMAN 27.488 211 139 6 97 298 302 507 2.26E-08 60.5 IGDC3_HUMAN reviewed Immunoglobulin superfamily DCC subclass member 3 (Putative neuronal cell adhesion molecule) IGDCC3 PUNC Homo sapiens (Human) 814 neuromuscular process controlling balance [GO:0050885] GO:0005887; GO:0050885 0 0 0 PF00041;PF07679; Q8N0N3 CHOYP_GNBPB3.1.1 m.55379 sp BGBP_PENMO 39.118 340 180 11 120 444 31 358 2.26E-68 224 BGBP_PENMO reviewed "Beta-1,3-glucan-binding protein (GBP)" 0 Penaeus monodon (Giant tiger prawn) 366 carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087] GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087 0 0 0 PF00722; Q91YE8 CHOYP_PHUM_PHUM596940.1.1 m.2151 sp SYNP2_MOUSE 48.276 87 43 1 1 85 1 87 2.26E-17 90.9 SYNP2_MOUSE reviewed Synaptopodin-2 (Myopodin) Synpo2 Mus musculus (Mouse) 1087 positive regulation of actin filament bundle assembly [GO:0032233] GO:0003779; GO:0005634; GO:0005925; GO:0015629; GO:0030018; GO:0032233; GO:0051371; GO:0071889 0 0 0 PF00595; Q99JL1 CHOYP_LOC100371058.1.3 m.20874 sp SPEF1_MOUSE 30.319 188 83 8 2 174 68 222 2.26E-12 66.6 SPEF1_MOUSE reviewed Sperm flagellar protein 1 Spef1 Mus musculus (Mouse) 234 0 GO:0005737; GO:0005930; GO:0031514 0 0 0 PF06294; Q9DCS2 CHOYP_LOC101068028.1.1 m.48693 sp CP013_MOUSE 48.438 192 96 2 30 220 1 190 2.26E-57 183 CP013_MOUSE reviewed UPF0585 protein C16orf13 homolog 0 Mus musculus (Mouse) 204 0 0 0 0 0 PF06080; Q9ESN6 CHOYP_TRIM3.52.58 m.53359 sp TRIM2_MOUSE 29.756 205 128 9 91 288 536 731 2.26E-13 73.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9FT69 CHOYP_RQSIM.1.1 m.61485 sp RQSIM_ARATH 34.682 173 97 6 19 186 140 301 2.26E-13 71.2 RQSIM_ARATH reviewed ATP-dependent DNA helicase Q-like SIM (EC 3.6.4.12) (RecQ-like protein SIM) (AtRecQsim) (Similar to RecQ protein) RECQSIM At5g27680 T1G16.10 Arabidopsis thaliana (Mouse-ear cress) 858 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0003677; GO:0005524; GO:0005634; GO:0005694; GO:0005737; GO:0006281; GO:0009378; GO:0043138; GO:0043140; GO:0046872 0 0 0 PF00270;PF00271;PF16124; Q9H0I2 CHOYP_BRAFLDRAFT_202836.1.1 m.10115 sp ENKD1_HUMAN 38.596 285 152 6 3 278 75 345 2.26E-52 177 ENKD1_HUMAN reviewed Enkurin domain-containing protein 1 ENKD1 C16orf48 UNQ6410/PRO21183 Homo sapiens (Human) 346 0 GO:0005881; GO:0015630 0 0 0 PF13864; Q9H0W7 CHOYP_LOC100570153.1.1 m.6546 sp THAP2_HUMAN 37.647 85 43 1 4 88 5 79 2.26E-09 60.1 THAP2_HUMAN reviewed THAP domain-containing protein 2 THAP2 Homo sapiens (Human) 228 0 GO:0003677; GO:0005730; GO:0046872 0 0 0 PF05485; Q9NDJ2 CHOYP_LOC101167297.1.1 m.37437 sp DOM_DROME 44.277 332 158 10 565 877 2006 2329 2.26E-73 276 DOM_DROME reviewed Helicase domino (EC 3.6.4.-) dom CG9696 Drosophila melanogaster (Fruit fly) 3198 "cell cycle [GO:0007049]; chromatin organization [GO:0006325]; dendrite guidance [GO:0070983]; dendrite morphogenesis [GO:0048813]; gene silencing [GO:0016458]; hemopoiesis [GO:0030097]; histone acetylation [GO:0016573]; histone exchange [GO:0043486]; instar larval or pupal development [GO:0002165]; male germ-line stem cell population maintenance [GO:0036098]; negative regulation of gene expression [GO:0010629]; negative regulation of hemocyte proliferation [GO:0035207]; neurogenesis [GO:0022008]; oogenesis [GO:0048477]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription, DNA-templated [GO:0006355]; sensory perception of pain [GO:0019233]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]; wing disc pattern formation [GO:0035222]" GO:0000123; GO:0000381; GO:0002165; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0006325; GO:0006351; GO:0006355; GO:0007049; GO:0008094; GO:0010629; GO:0010906; GO:0016458; GO:0016573; GO:0019233; GO:0022008; GO:0030097; GO:0035019; GO:0035207; GO:0035222; GO:0035267; GO:0036098; GO:0043486; GO:0045747; GO:0048477; GO:0048813; GO:0070983; GO:2000637 0 0 0 PF00271;PF07529;PF00176; Q9UH77 CHOYP_LOC101069892.1.1 m.22367 sp KLHL3_HUMAN 37.963 108 65 2 112 217 376 483 2.26E-12 68.9 KLHL3_HUMAN reviewed Kelch-like protein 3 KLHL3 KIAA1129 Homo sapiens (Human) 587 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005198; GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q9WTS8 CHOYP_ANGL2.1.1 m.33554 sp FCN1_RAT 44.231 260 130 9 115 372 89 335 2.26E-58 196 FCN1_RAT reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Rattus norvegicus (Rat) 335 cell surface pattern recognition receptor signaling pathway [GO:0002752]; G-protein coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; positive regulation of interleukin-8 secretion [GO:2000484] GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0045087; GO:0046872; GO:2000484 0 0 0 PF01391;PF00147; Q9WVE8 CHOYP_AAEL_AAEL001979.1.1 m.58086 sp PACN2_MOUSE 43.865 326 180 2 8 332 11 334 2.26E-102 322 PACN2_MOUSE reviewed Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) Pacsin2 Mus musculus (Mouse) 486 actin cytoskeleton organization [GO:0030036]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell projection morphogenesis [GO:0048858]; membrane tubulation [GO:0097320]; negative regulation of endocytosis [GO:0045806]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165] GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005856; GO:0005901; GO:0005911; GO:0005925; GO:0007165; GO:0008092; GO:0008289; GO:0019898; GO:0030036; GO:0030659; GO:0032587; GO:0036010; GO:0042802; GO:0043231; GO:0045806; GO:0048858; GO:0055038; GO:0070062; GO:0070300; GO:0070836; GO:0072584; GO:0097320 0 0 0 PF00611;PF00018; A4D263 CHOYP_LOC100367356.1.1 m.29181 sp CG072_HUMAN 33.714 350 211 7 87 427 96 433 2.27E-40 152 CG072_HUMAN reviewed Uncharacterized protein C7orf72 C7orf72 Homo sapiens (Human) 438 0 0 0 0 0 PF15073; B3EWZ6 CHOYP_BRAFLDRAFT_150688.1.1 m.2187 sp MLRP2_ACRMI 44.379 169 87 4 287 453 1392 1555 2.27E-36 147 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E9QAM5 CHOYP_LOC100369525.2.2 m.57727 sp HELZ2_MOUSE 40.72 528 269 17 78 582 2417 2923 2.27E-108 362 HELZ2_MOUSE reviewed Helicase with zinc finger domain 2 (EC 3.6.4.-) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) Helz2 Mus musculus (Mouse) 2947 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 H1AFJ5 CHOYP_LOC100891438.1.3 m.24390 sp SCNNA_NEOFS 23.708 561 365 10 112 630 23 562 2.27E-43 169 SCNNA_NEOFS reviewed Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA) scnn1a enacalpha Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri) 655 sodium ion transmembrane transport [GO:0035725] GO:0005929; GO:0015280; GO:0016324; GO:0034706; GO:0035725 0 0 0 PF00858; O01761 CHOYP_C1QT4.3.5 m.46405 sp UNC89_CAEEL 26.812 276 172 11 101 359 3255 3517 2.27E-10 68.2 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O14733 CHOYP_MP2K7.1.2 m.1886 sp MP2K7_HUMAN 62.222 405 142 4 3 405 2 397 2.27E-170 486 MP2K7_HUMAN reviewed Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2) MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4 Homo sapiens (Human) 419 activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular response to sorbitol [GO:0072709]; Fc-epsilon receptor signaling pathway [GO:0038095]; JNK cascade [GO:0007254]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; proteolysis in other organism [GO:0035897]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403] GO:0000287; GO:0004702; GO:0004708; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0006970; GO:0007165; GO:0007254; GO:0007257; GO:0008545; GO:0009408; GO:0009411; GO:0019899; GO:0019901; GO:0019903; GO:0032212; GO:0034612; GO:0035897; GO:0038095; GO:0043525; GO:0051403; GO:0051973; GO:0072709; GO:1904355 0 0 0 PF00069; O55043 CHOYP_ARHG7.1.5 m.1641 sp ARHG7_RAT 44.165 677 311 16 11 663 11 644 2.27E-169 501 ARHG7_RAT reviewed Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) Arhgef7 Pak3bp Pixb Rattus norvegicus (Rat) 646 astrocyte cell migration [GO:0043615]; lamellipodium assembly [GO:0030032]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264] GO:0001726; GO:0005085; GO:0005089; GO:0005737; GO:0005925; GO:0005938; GO:0007264; GO:0019901; GO:0030027; GO:0030032; GO:0030426; GO:0035023; GO:0043065; GO:0043615 0 0 0 PF16523;PF00169;PF00621;PF07653; O75179 CHOYP_LOC100641396.5.27 m.24209 sp ANR17_HUMAN 34.416 462 276 17 37 478 275 729 2.27E-50 189 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O94759 CHOYP_TRPM5.2.2 m.65289 sp TRPM2_HUMAN 25.911 494 287 13 538 979 620 1086 2.27E-31 137 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; O95490 CHOYP_LOC100890274.1.1 m.33227 sp AGRL2_HUMAN 22.055 730 480 27 289 993 427 1092 2.27E-38 160 AGRL2_HUMAN reviewed Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1) ADGRL2 KIAA0786 LEC1 LPHH1 LPHN2 Homo sapiens (Human) 1459 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0004930; GO:0007166; GO:0007186; GO:0016021; GO:0016524; GO:0030246 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; P08045 CHOYP_XFIN.3.4 m.18609 sp XFIN_XENLA 25.327 841 494 24 373 1127 505 1297 2.27E-55 215 XFIN_XENLA reviewed Zinc finger protein Xfin (Xenopus fingers protein) (Xfin) 0 Xenopus laevis (African clawed frog) 1350 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003723; GO:0005737; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; P0C7B7 CHOYP_LOC762549.1.2 m.39714 sp ELIC_DICCH 26.136 264 177 6 55 307 12 268 2.27E-15 80.1 ELIC_DICCH reviewed Cys-loop ligand-gated ion channel (ELIC) 0 Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) 321 0 GO:0005230; GO:0005886; GO:0016021 0 0 0 PF02931; P10079 CHOYP_LOC100634060.20.37 m.41800 sp FBP1_STRPU 54.974 191 86 0 277 467 214 404 2.27E-57 212 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P22807 CHOYP_NEMVEDRAFT_V1G197493.1.1 m.9554 sp SLOU_DROME 46.581 234 88 8 61 278 446 658 2.27E-42 157 SLOU_DROME reviewed Homeobox protein slou (Homeobox protein NK-1) (Protein slouch) (S59/2) slou NK1 S59 CG6534 Drosophila melanogaster (Fruit fly) 659 mesodermal cell fate specification [GO:0007501]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122] GO:0000122; GO:0005634; GO:0007501; GO:0007517; GO:0007521; GO:0043565 0 0 0 PF00046; P31646 CHOYP_SC6A8.1.1 m.33915 sp S6A13_RAT 41.93 601 307 8 40 635 10 573 2.27E-170 503 S6A13_RAT reviewed Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gat-2 Rattus norvegicus (Rat) 602 chemical synaptic transmission [GO:0007268]; neurotransmitter transport [GO:0006836] GO:0005328; GO:0005332; GO:0005887; GO:0006836; GO:0007268; GO:0042165; GO:0043005 0 0 0 PF00209; P32100 CHOYP_ISCW_ISCW004030.1.1 m.13862 sp RL7_DROME 68.707 147 45 1 5 150 106 252 2.27E-71 218 RL7_DROME reviewed 60S ribosomal protein L7 RpL7 CG4897 Drosophila melanogaster (Fruit fly) 252 "centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; pupariation [GO:0035073]" GO:0000022; GO:0000463; GO:0002181; GO:0003735; GO:0005840; GO:0007052; GO:0022625; GO:0035073; GO:0044822; GO:0051298 0 0 0 PF00327;PF08079; P42577 CHOYP_BRAFLDRAFT_114663.1.1 m.49867 sp FRIS_LYMST 62.5 72 26 1 10 81 67 137 2.27E-22 88.6 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P55214 CHOYP_CASP7.3.23 m.5586 sp CASP7_MESAU 31.902 163 84 4 21 183 83 218 2.27E-13 73.2 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q04164 CHOYP_CRIM1.1.3 m.5079 sp SAS_DROME 24.839 310 165 15 261 557 523 777 2.27E-06 55.1 SAS_DROME reviewed Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) 1693 axon guidance [GO:0007411]; instar larval development [GO:0002168] GO:0002168; GO:0004872; GO:0005887; GO:0007411; GO:0016324 0 0 0 PF00041; Q14980 CHOYP_TVAG_012450.3.8 m.19707 sp NUMA1_HUMAN 58.974 39 15 1 887 924 1904 1942 2.27E-08 62.4 NUMA1_HUMAN reviewed Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) 2115 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997] GO:0000132; GO:0000139; GO:0000922; GO:0005198; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005876; GO:0005938; GO:0006997; GO:0007067; GO:0016363; GO:0030425; GO:0043025; GO:0045177; GO:0051301; GO:0051321; GO:0060487; GO:0061673; GO:0070062; GO:0072686; GO:0097431 0 0 0 0 Q16534 CHOYP_LOC726528.1.2 m.13677 sp HLF_HUMAN 56.164 73 32 0 194 266 219 291 2.27E-19 88.6 HLF_HUMAN reviewed Hepatic leukemia factor HLF Homo sapiens (Human) 295 multicellular organism development [GO:0007275]; rhythmic process [GO:0048511]; skeletal muscle cell differentiation [GO:0035914]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000977; GO:0001077; GO:0003677; GO:0003690; GO:0005634; GO:0006366; GO:0007275; GO:0035914; GO:0048511 0 0 0 PF07716; Q3T0H0 CHOYP_LCMT1.1.1 m.56024 sp LCMT1_BOVIN 50 308 150 2 4 308 21 327 2.27E-106 316 LCMT1_BOVIN reviewed Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1) LCMT1 Bos taurus (Bovine) 332 C-terminal protein methylation [GO:0006481]; negative regulation of protein complex assembly [GO:0031333]; regulation of apoptotic process [GO:0042981]; regulation of glucose metabolic process [GO:0010906]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266] GO:0005829; GO:0006481; GO:0010906; GO:0018423; GO:0031333; GO:0042981; GO:0090266 0 0 0 PF04072; Q502M6 CHOYP_TVAG_451090.6.13 m.54139 sp ANR29_DANRE 39.326 178 108 0 12 189 43 220 2.27E-37 134 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q54KA7 CHOYP_TVAG_452670.2.2 m.45777 sp SECG_DICDI 32.086 187 124 2 2 187 259 443 2.27E-19 94.4 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5E9E1 CHOYP_PDLI7.1.1 m.61556 sp PDLI1_BOVIN 46.914 81 39 2 24 103 6 83 2.27E-13 75.9 PDLI1_BOVIN reviewed PDZ and LIM domain protein 1 (Elfin) PDLIM1 Bos taurus (Bovine) 328 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003713; GO:0005667; GO:0005737; GO:0005856; GO:0006355; GO:0008270 0 0 0 PF15936;PF00412;PF00595; Q5RBL0 CHOYP_BRAFLDRAFT_70406.1.1 m.20022 sp YIPF1_PONAB 45.745 282 127 6 32 290 5 283 2.27E-76 240 YIPF1_PONAB reviewed Protein YIPF1 (YIP1 family member 1) YIPF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 306 0 GO:0016021 0 0 0 PF04893; Q61686 CHOYP_CBX1.3.4 m.27106 sp CBX5_MOUSE 57.714 175 54 3 64 225 20 187 2.27E-61 193 CBX5_MOUSE reviewed Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) Cbx5 Hp1a Mus musculus (Mouse) 191 "negative regulation of transcription, DNA-templated [GO:0045892]" GO:0000118; GO:0000776; GO:0000784; GO:0000792; GO:0003682; GO:0005634; GO:0005720; GO:0005721; GO:0005730; GO:0010369; GO:0016605; GO:0017053; GO:0030674; GO:0035064; GO:0035097; GO:0042803; GO:0042826; GO:0045892; GO:0070491 0 0 0 PF00385;PF01393; Q69Z37 CHOYP_SAM9L.2.2 m.64218 sp SAM9L_MOUSE 30.675 163 100 5 347 504 169 323 2.27E-16 86.3 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6AXX3 CHOYP_contig_015674 m.18336 sp Z385D_RAT 37.313 67 40 2 75 140 44 109 2.27E-06 48.9 Z385D_RAT reviewed Zinc finger protein 385D (Zinc finger protein 659) Znf385d Znf659 Rattus norvegicus (Rat) 395 intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332] GO:0002039; GO:0003723; GO:0005634; GO:0008270; GO:0072332 0 0 0 0 Q6B9X6 CHOYP_LOC100372473.5.5 m.63574 sp VWKA_DICDI 28.814 177 114 5 5 180 121 286 2.27E-12 71.6 VWKA_DICDI reviewed Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) 625 contractile vacuole discharge [GO:0070177]; contractile vacuole organization [GO:0033298]; hypotonic response [GO:0006971]; mitotic cytokinesis [GO:0000281]; myosin II filament organization [GO:0031038]; peptidyl-serine modification [GO:0018209]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; regulation of sorocarp development [GO:0031156]; sorocarp morphogenesis [GO:0031288] GO:0000281; GO:0000331; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006971; GO:0018107; GO:0018209; GO:0031038; GO:0031156; GO:0031164; GO:0031288; GO:0033298; GO:0048471; GO:0070177 0 0 0 PF02816; Q6TMK8 CHOYP_SLMO2.1.1 m.1350 sp PLD3B_CRIGR 47.647 170 88 1 1 169 1 170 2.27E-54 174 PLD3B_CRIGR reviewed PRELI domain containing protein 3B (BCR/ABL-regulated protein) (Protein slowmo homolog 2) PRELID3B C20orf45 SLMO2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 195 0 0 0 0 0 PF04707; Q86XX4 CHOYP_FRAS1.3.4 m.22409 sp FRAS1_HUMAN 36.15 426 255 4 1 412 6 428 2.27E-81 276 FRAS1_HUMAN reviewed Extracellular matrix protein FRAS1 FRAS1 KIAA1500 Homo sapiens (Human) 4008 cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; palate development [GO:0060021]; protein transport [GO:0015031]; skin development [GO:0043588] GO:0002009; GO:0003338; GO:0005886; GO:0007154; GO:0015031; GO:0016021; GO:0030326; GO:0043588; GO:0046872; GO:0060021; GO:0061618 0 0 0 PF03160;PF00093; Q8HYJ4 CHOYP_ISCW_ISCW004236.5.5 m.51292 sp FUT5_PONPY 31.142 289 176 7 77 354 82 358 2.27E-31 125 FUT5_PONPY reviewed "Alpha-(1,3)-fucosyltransferase 5 (EC 2.4.1.65) (Fucosyltransferase 5) (Fucosyltransferase V) (Fuc-TV) (FucT-V) (Galactoside 3-L-fucosyltransferase)" FUT5 Pongo pygmaeus (Bornean orangutan) 374 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0017060; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q8IV45 CHOYP_UNC5C.1.1 m.62081 sp UN5CL_HUMAN 26.25 400 262 12 195 569 102 493 2.27E-25 113 UN5CL_HUMAN reviewed UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein) UNC5CL ZUD Homo sapiens (Human) 518 positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330]; signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0008233; GO:0016020; GO:0016021; GO:0043123; GO:0046330 0 0 0 PF00531;PF00791; Q8IYB1 CHOYP_NEMVEDRAFT_V1G196611.12.13 m.58360 sp M21D2_HUMAN 25.714 175 109 6 159 326 225 385 2.27E-07 56.6 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8MP06 CHOYP_LOC591085.1.1 m.63777 sp SNO1_TYRJA 37.069 116 71 1 2 117 22 135 2.27E-18 82.4 SNO1_TYRJA reviewed Senecionine N-oxygenase (SNO) (EC 1.14.13.101) sno1 Tyria jacobaeae (Cinnabar moth) 456 alkaloid metabolic process [GO:0009820]; oxidation-reduction process [GO:0055114]; protein homotetramerization [GO:0051289] GO:0004499; GO:0005576; GO:0009820; GO:0033784; GO:0050660; GO:0050661; GO:0051289; GO:0055114 0 0 0 PF00743; Q8N6G6 CHOYP_SMP_145890.1.1 m.47628 sp ATL1_HUMAN 32.081 346 212 11 179 510 670 1006 2.27E-38 157 ATL1_HUMAN reviewed ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) ADAMTSL1 ADAMTSR1 C9orf94 UNQ528/PRO1071 Homo sapiens (Human) 1762 protein O-linked fucosylation [GO:0036066] GO:0005578; GO:0005788; GO:0008237; GO:0008270; GO:0036066 0 0 0 PF07679;PF08686;PF00090; Q8VI56 CHOYP_LOC578599.2.8 m.20963 sp LRP4_MOUSE 26.207 870 574 24 108 944 514 1348 2.27E-83 304 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q8VIJ6 CHOYP_LOC593522.2.2 m.33859 sp SFPQ_MOUSE 53.986 276 127 0 61 336 283 558 2.27E-99 313 SFPQ_MOUSE reviewed "Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" Sfpq Psf Mus musculus (Mouse) 699 "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to DNA damage stimulus [GO:0006974]; chromosome organization [GO:0051276]; double-strand break repair via homologous recombination [GO:0000724]; histone H3 deacetylation [GO:0070932]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of sister chromatid cohesion [GO:0045876]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0000380; GO:0000724; GO:0000785; GO:0000976; GO:0000980; GO:0001047; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006974; GO:0016363; GO:0042382; GO:0042752; GO:0042754; GO:0042826; GO:0044212; GO:0044822; GO:0045876; GO:0045892; GO:0048511; GO:0051276; GO:0051726; GO:0070932; GO:0090575; GO:1902177 0 0 0 PF08075;PF00076; Q96PN6 CHOYP_LOC574069.1.1 m.45632 sp ADCYA_HUMAN 25.738 1422 883 40 339 1675 238 1571 2.27E-98 354 ADCYA_HUMAN reviewed Adenylate cyclase type 10 (EC 4.6.1.1) (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase) ADCY10 SAC Homo sapiens (Human) 1610 cAMP biosynthetic process [GO:0006171]; cellular response to inorganic substance [GO:0071241]; epithelial cilium movement [GO:0003351]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; spermatogenesis [GO:0007283] GO:0000287; GO:0003351; GO:0004016; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005856; GO:0005886; GO:0005929; GO:0006171; GO:0007283; GO:0030145; GO:0030424; GO:0030425; GO:0030426; GO:0035556; GO:0043025; GO:0043065; GO:0045177; GO:0045178; GO:0048471; GO:0071241; GO:0071890 0 0 0 PF00211; Q99M80 CHOYP_PTPRT.35.45 m.56875 sp PTPRT_MOUSE 34.791 549 328 12 612 1136 882 1424 2.27E-72 268 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BZK3 CHOYP_ISCW_ISCW012592.1.2 m.1530 sp NACP1_HUMAN 66.372 113 36 1 7 117 10 122 2.27E-43 144 NACP1_HUMAN reviewed Putative nascent polypeptide-associated complex subunit alpha-like protein (Alpha-NAC pseudogene 1) (NAC-alpha pseudogene 1) NACAP1 FKSG17 Homo sapiens (Human) 213 0 0 0 0 0 PF01849; Q9CWL2 CHOYP_LOC100749506.1.1 m.8950 sp CASZ1_MOUSE 48.968 339 145 6 304 638 380 694 2.27E-91 333 CASZ1_MOUSE reviewed Zinc finger protein castor homolog 1 (Castor-related protein) Casz1 Cst D4Ertd432e Kiaa3026 Mus musculus (Mouse) 1761 "central nervous system development [GO:0007417]; negative regulation of amacrine cell differentiation [GO:1902870]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinal cone cell fate commitment [GO:0060226]; regulation of transcription, DNA-templated [GO:0006355]; retinal bipolar neuron differentiation [GO:0060040]; retinal rod cell fate commitment [GO:0060223]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0007417; GO:0043231; GO:0045665; GO:0046872; GO:0060040; GO:0060223; GO:0060226; GO:1902870 0 0 0 0 Q9HCU4 CHOYP_FAT4.9.10 m.49153 sp CELR2_HUMAN 30.807 818 519 18 6 792 173 974 2.27E-95 330 CELR2_HUMAN reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) 2923 "dendrite morphogenesis [GO:0048813]; G-protein coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0007186; GO:0007283; GO:0016021; GO:0016055; GO:0021999; GO:0022407; GO:0048813; GO:0060071 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF12661;PF00053;PF02210; Q9JLI6 CHOYP_SCLY.2.3 m.12126 sp SCLY_MOUSE 54.938 162 71 1 1 160 270 431 2.27E-56 185 SCLY_MOUSE reviewed Selenocysteine lyase (mSCL) (EC 4.4.1.16) Scly Scl Mus musculus (Mouse) 432 lipid metabolic process [GO:0006629]; negative regulation of cellular response to oxidative stress [GO:1900408]; response to insulin [GO:0032868]; selenium compound metabolic process [GO:0001887] GO:0001887; GO:0005829; GO:0006629; GO:0009000; GO:0016740; GO:0032868; GO:1900408 0 0 0 PF00266; Q9QZI7 CHOYP_TSAP1.1.2 m.36103 sp TSAP1_RAT 41.667 72 38 1 31 102 219 286 2.27E-09 55.8 TSAP1_RAT reviewed tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) Trnau1ap Secp43 Trspap1 Rattus norvegicus (Rat) 287 selenocysteine incorporation [GO:0001514] GO:0000049; GO:0000166; GO:0001514; GO:0005634; GO:0005737 0 0 0 PF00076; Q9X248 CHOYP_LOC100704819.2.2 m.49100 sp FABG_THEMA 41.2 250 137 5 17 264 2 243 2.27E-53 176 FABG_THEMA reviewed 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) 246 fatty acid elongation [GO:0030497] GO:0004316; GO:0030497; GO:0050661; GO:0051287; GO:0102132 PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 0 A0JNC4 CHOYP_ELOV7.1.1 m.12230 sp ELOV7_BOVIN 57.692 260 101 5 5 255 11 270 2.28E-106 312 ELOV7_BOVIN reviewed Elongation of very long chain fatty acids protein 7 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL7) (ELOVL fatty acid elongase 7) (ELOVL FA elongase 7) (Very long chain 3-ketoacyl-CoA synthase 7) (Very long chain 3-oxoacyl-CoA synthase 7) ELOVL7 Bos taurus (Bovine) 281 "fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" GO:0005783; GO:0006636; GO:0009922; GO:0019367; GO:0030148; GO:0030176; GO:0034625; GO:0034626; GO:0035338; GO:0042761; GO:0102336; GO:0102337; GO:0102338 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03207}. 0 0 PF01151; A2VDU3 CHOYP_M3K7.2.4 m.17370 sp M3K7_BOVIN 75.85 294 67 3 1 294 42 331 2.28E-167 480 M3K7_BOVIN reviewed Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) MAP3K7 Bos taurus (Bovine) 579 "activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; histone H3 acetylation [GO:0043966]; I-kappaB phosphorylation [GO:0007252]; JNK cascade [GO:0007254]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of T cell cytokine production [GO:0002726]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000186; GO:0000187; GO:0000287; GO:0002726; GO:0004709; GO:0005524; GO:0005622; GO:0005671; GO:0005886; GO:0006351; GO:0006355; GO:0006915; GO:0007250; GO:0007252; GO:0007254; GO:0008385; GO:0032743; GO:0043123; GO:0043507; GO:0043966 0 0 0 PF07714; A4IF63 CHOYP_BRAFLDRAFT_71615.2.3 m.59566 sp TRIM2_BOVIN 25.352 142 105 1 146 286 602 743 2.28E-07 56.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_LOC101175583.1.1 m.32402 sp TRIM2_BOVIN 24.797 246 129 9 193 388 492 731 2.28E-09 62.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_87320.1.2 m.3763 sp TRIM2_AILME 25.185 270 171 10 243 496 488 742 2.28E-11 70.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O16277 CHOYP_LOC100635715.1.9 m.6278 sp H16_CAEEL 55.556 99 43 1 27 124 25 123 2.28E-25 100 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O23300 CHOYP_TRIADDRAFT_52755.1.1 m.64495 sp ECI3_ARATH 34.715 193 117 5 35 219 33 224 2.28E-26 104 ECI3_ARATH reviewed "Enoyl-CoA delta isomerase 3 (EC 5.3.3.8) (3-hydroxyacyl-CoA dehydratase 1) (Delta(3),Delta(2)-enoyl CoA isomerase 3) (AtECI3)" ECI3 HCD1 At4g14440 dl3260c Arabidopsis thaliana (Mouse-ear cress) 238 fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062]; response to karrikin [GO:0080167] GO:0004165; GO:0005634; GO:0005829; GO:0006635; GO:0009062; GO:0080167 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000305}. 0 0 PF00378; O43301 CHOYP_HS12A.28.33 m.61121 sp HS12A_HUMAN 29.841 315 207 4 14 320 365 673 2.28E-41 155 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75179 CHOYP_LOC593853.3.4 m.48570 sp ANR17_HUMAN 34.81 474 283 14 305 756 222 691 2.28E-54 207 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P04792 CHOYP_CRYAB.2.5 m.23200 sp HSPB1_HUMAN 37.234 94 57 2 46 138 89 181 2.28E-09 58.5 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P09481 CHOYP_LOC100368788.2.2 m.40886 sp ACHA3_CHICK 31.173 324 214 5 6 322 23 344 2.28E-52 185 ACHA3_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) 496 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; P21941 CHOYP_LOC101173335.3.4 m.41619 sp MATN1_HUMAN 29.341 334 187 13 15 328 120 424 2.28E-26 112 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P25067 CHOYP_CBLN13.8.9 m.58624 sp CO8A2_HUMAN 30.851 94 57 2 123 211 586 676 2.28E-06 51.2 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; P27473 CHOYP_BRAFLDRAFT_99019.8.8 m.62207 sp IFI44_PANTR 29.399 449 273 10 12 448 7 423 2.28E-51 184 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P43679 CHOYP_LOC581710.1.1 m.53405 sp ACHB3_CHICK 28.829 333 218 6 20 342 4 327 2.28E-32 131 ACHB3_CHICK reviewed Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Gallus gallus (Chicken) 455 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P45842 CHOYP_NEMVEDRAFT_V1G237122.6.6 m.53198 sp RL34_AEDAL 71.429 112 31 1 1 112 1 111 2.28E-49 156 RL34_AEDAL reviewed 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01199; P46791 CHOYP_RS2.5.10 m.29940 sp RS2_CRIGR 90.244 123 12 0 1 123 78 200 2.28E-77 230 RS2_CRIGR reviewed 40S ribosomal protein S2 (Fragment) RPS2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 202 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; P62248 CHOYP_LOC100119310.1.1 m.22032 sp MYDGF_BOVIN 38.519 135 73 3 29 154 41 174 2.28E-25 98.2 MYDGF_BOVIN reviewed Myeloid-derived growth factor (MYDGF) MYDGF Bos taurus (Bovine) 174 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001525; GO:0001934; GO:0001938; GO:0005576; GO:0005615; GO:0005793; GO:0006915; GO:0014068; GO:0043066; GO:0043410; GO:0045766; GO:0045944; GO:0051897; GO:0070062 0 0 0 PF10572; P97521 CHOYP_ISCW_ISCW022609.1.1 m.26988 sp MCAT_RAT 67.808 292 94 0 5 296 9 300 2.28E-150 426 MCAT_RAT reviewed Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (Solute carrier family 25 member 20) Slc25a20 Cact Rattus norvegicus (Rat) 301 translation [GO:0006412]; transport [GO:0006810] GO:0003735; GO:0005743; GO:0006412; GO:0006810; GO:0016021 0 0 0 PF00153; Q03650 CHOYP_DSPP.8.8 m.65418 sp CRAM_TRYBB 27.5 640 448 11 183 817 63 691 2.28E-21 103 CRAM_TRYBB reviewed "Cysteine-rich, acidic integral membrane protein" CRAM Trypanosoma brucei brucei 945 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021; GO:0020016 0 0 0 PF07016; Q12955 CHOYP_TVAG_168010.31.45 m.54524 sp ANK3_HUMAN 32.109 735 495 1 169 903 48 778 2.28E-117 399 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q5F339 CHOYP_LOC100897670.1.1 m.5436 sp CCHL_CHICK 64.257 249 52 5 12 228 28 271 2.28E-107 313 CCHL_CHICK reviewed Cytochrome c-type heme lyase (CCHL) (EC 4.4.1.17) (Holocytochrome c-type synthase) HCCS RCJMB04_37l21 Gallus gallus (Chicken) 273 0 GO:0004408; GO:0005743; GO:0046872 0 0 0 PF01265; Q5I4F9 CHOYP_AQP4.2.3 m.22105 sp AQP4_NOTAL 36.9 271 162 4 16 278 30 299 2.28E-51 174 AQP4_NOTAL reviewed Aquaporin-4 (AQP-4) AQP4 Notomys alexis (Spinifex hopping mouse) 326 0 GO:0005215; GO:0016021 0 0 cd00333; PF00230; Q6AXS0 CHOYP_LOC100448959.1.1 m.5342 sp NCKX6_RAT 47.794 136 67 2 51 182 18 153 2.28E-32 124 NCKX6_RAT reviewed "Sodium/potassium/calcium exchanger 6, mitochondrial (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)" Slc8b1 Nckx6 Nclx Slc24a6 Rattus norvegicus (Rat) 585 glucose homeostasis [GO:0042593]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; response to stimulus [GO:0050896] GO:0005432; GO:0005739; GO:0005743; GO:0005829; GO:0006851; GO:0030061; GO:0032592; GO:0042383; GO:0042593; GO:0042802; GO:0042803; GO:0050796; GO:0050896; GO:0051480; GO:0051560 0 0 0 PF01699; Q6JZS3 CHOYP_CYP1A.1.1 m.56350 sp CP1A1_ORYLA 40.278 144 78 4 50 187 16 157 2.28E-22 97.4 CP1A1_ORYLA reviewed Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) cyp1a1 cyp1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 521 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q6SZ65 CHOYP_OTP.1.1 m.29333 sp OTP_LYTVA 52.14 257 90 7 57 283 105 358 2.28E-62 203 OTP_LYTVA reviewed Homeobox protein orthopedia Otp Lytechinus variegatus (Green sea urchin) (Variegated urchin) 360 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046;PF03826; Q6ZPT1 CHOYP_KLH26.1.2 m.8792 sp KLHL9_MOUSE 28.519 270 171 7 78 342 348 600 2.28E-24 107 KLHL9_MOUSE reviewed Kelch-like protein 9 Klhl9 Kiaa1354 Mus musculus (Mouse) 617 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q80T91 CHOYP_PEAR1.15.16 m.64729 sp MEG11_MOUSE 38.211 246 133 11 174 419 426 652 2.28E-27 120 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8K0U4 CHOYP_BRAFLDRAFT_208436.3.32 m.22603 sp HS12A_MOUSE 32.473 465 247 12 19 438 56 498 2.28E-67 230 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8WTU2 CHOYP_BRAFLDRAFT_243719.2.2 m.54434 sp SRB4D_HUMAN 33.21 539 215 13 3 515 96 515 2.28E-68 233 SRB4D_HUMAN reviewed Scavenger receptor cysteine-rich domain-containing group B protein (Four scavenger receptor cysteine-rich domains-containing protein) (S4D-SRCRB) SSC4D SRCRB4D Homo sapiens (Human) 575 0 GO:0005044; GO:0016020; GO:0070062 0 0 0 PF00530; Q91YU8 CHOYP_PPAN-B.1.1 m.2112 sp SSF1_MOUSE 48.172 465 204 7 22 468 23 468 2.28E-152 448 SSF1_MOUSE reviewed Suppressor of SWI4 1 homolog (Ssf-1) (Peter Pan homolog) Ppan Ssf1 Mus musculus (Mouse) 470 regulation of cell growth by extracellular stimulus [GO:0001560]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0001560; GO:0005634; GO:0005730; GO:0019843; GO:0030687; GO:0044822 0 0 0 PF04427; Q92982 CHOYP_LOC100123713.1.3 m.14129 sp NINJ1_HUMAN 27.632 76 55 0 130 205 39 114 2.28E-06 49.7 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q99KF0 CHOYP_LOC100486738.2.2 m.64461 sp CAR14_MOUSE 22.438 771 481 30 6 712 15 732 2.28E-13 78.2 CAR14_MOUSE reviewed Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2) Card14 Bimp2 Mus musculus (Mouse) 999 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001934; GO:0005737; GO:0006915; GO:0033209; GO:0043066; GO:0050700; GO:0051092 0 0 0 PF00619; Q9CQX8 CHOYP_LOC101157864.2.2 m.28216 sp RT36_MOUSE 39.604 101 43 4 9 95 5 101 2.28E-10 56.2 RT36_MOUSE reviewed "28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt)" Mrps36 Mus musculus (Mouse) 102 2-oxoglutarate metabolic process [GO:0006103]; oxidation-reduction process [GO:0055114] GO:0005739; GO:0005763; GO:0006103; GO:0009353; GO:0055114 0 0 0 PF10937; Q9CXS4 CHOYP_NR1H4.2.2 m.54741 sp CENPV_MOUSE 62.5 128 47 1 8 134 125 252 2.28E-58 184 CENPV_MOUSE reviewed Centromere protein V (CENP-V) (Proline-rich protein 6) Cenpv Prr6 Mus musculus (Mouse) 252 ameboidal-type cell migration [GO:0001667]; cell division [GO:0051301]; centromere complex assembly [GO:0034508]; metabolic process [GO:0008152]; mitotic nuclear division [GO:0007067]; pericentric heterochromatin assembly [GO:0031508]; positive regulation of cytokinesis [GO:0032467]; regulation of chromosome organization [GO:0033044] GO:0000776; GO:0000777; GO:0001667; GO:0005634; GO:0005654; GO:0005737; GO:0007067; GO:0008152; GO:0015630; GO:0016846; GO:0031508; GO:0032467; GO:0033044; GO:0034508; GO:0051233; GO:0051301 0 0 0 PF04828; Q9DBQ9 CHOYP_LOC101238772.1.1 m.7032 sp SWT1_MOUSE 31.474 251 142 5 478 715 384 617 2.28E-23 109 SWT1_MOUSE reviewed Transcriptional protein SWT1 Swt1 Mus musculus (Mouse) 907 0 0 0 0 0 PF13638; Q9ESN6 CHOYP_BRAFLDRAFT_79377.7.30 m.23957 sp TRIM2_MOUSE 25.751 233 151 10 237 457 484 706 2.28E-10 66.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JLL3 CHOYP_LOC100485234.1.1 m.28068 sp TNR19_MOUSE 29.839 124 73 5 14 133 10 123 2.28E-06 52.8 TNR19_MOUSE reviewed Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer) Tnfrsf19 Taj Troy Mus musculus (Mouse) 416 hair follicle development [GO:0001942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330] GO:0001942; GO:0004872; GO:0005576; GO:0005886; GO:0016021; GO:0043123; GO:0046330 0 0 0 PF00020; Q9UGM3 CHOYP_DMBT1.12.34 m.24064 sp DMBT1_HUMAN 43.21 486 200 11 3 416 530 1011 2.28E-96 319 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UMZ3 CHOYP_PTPRQ.8.8 m.66937 sp PTPRQ_HUMAN 27.728 559 326 27 133 653 1785 2303 2.28E-34 144 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; Q9UPY8 CHOYP_MARE3.1.1 m.30069 sp MARE3_HUMAN 55.957 277 112 5 58 325 1 276 2.28E-105 312 MARE3_HUMAN reviewed Microtubule-associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End-binding protein 3) (EB3) (RP3) MAPRE3 Homo sapiens (Human) 281 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of microtubule plus-end binding [GO:1903033]; positive regulation of transcription, DNA-templated [GO:0045893]" GO:0005737; GO:0007067; GO:0008017; GO:0015630; GO:0030496; GO:0035371; GO:0042802; GO:0045737; GO:0045893; GO:0048471; GO:0051301; GO:1903033 0 0 0 PF00307;PF03271; Q9Y2C4 CHOYP_EXOG.1.1 m.15991 sp EXOG_HUMAN 56.067 239 101 2 53 288 64 301 2.28E-98 296 EXOG_HUMAN reviewed "Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)" EXOG ENDOGL1 ENDOGL2 ENGL Homo sapiens (Human) 368 0 GO:0003676; GO:0004519; GO:0005743; GO:0043234; GO:0046872 0 0 0 PF01223; Q9ZQ47 CHOYP_LOC100367312.12.13 m.43087 sp GRDP1_ARATH 37.762 286 166 4 5 282 15 296 2.28E-52 200 GRDP1_ARATH reviewed Glycine-rich domain-containing protein 1 (AtGRDP1) GRDP1 At2g22660 T9I22.10 Arabidopsis thaliana (Mouse-ear cress) 819 abscisic acid-activated signaling pathway [GO:0009738]; cellular response to osmotic stress [GO:0071470]; regulation of abscisic acid-activated signaling pathway [GO:0009787]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650] GO:0005198; GO:0005886; GO:0006979; GO:0009650; GO:0009738; GO:0009787; GO:0071470 0 0 0 PF07173; A6NJI9 CHOYP_LOC100370463.1.1 m.30276 sp LRC72_HUMAN 32.222 270 174 4 6 272 24 287 2.29E-44 154 LRC72_HUMAN reviewed Leucine-rich repeat-containing protein 72 LRRC72 Homo sapiens (Human) 287 melanocyte differentiation [GO:0030318] GO:0030318 0 0 0 0 A6NMZ7 CHOYP_COL6A6.2.2 m.65543 sp CO6A6_HUMAN 24 450 306 13 14 456 566 986 2.29E-25 119 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; B3EWY9 CHOYP_BRAFLDRAFT_129967.2.4 m.5568 sp MLP_ACRMI 27.684 1062 619 41 813 1815 394 1365 2.29E-96 350 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; D6REC4 CHOYP_BRAFLDRAFT_128345.1.1 m.9897 sp CFA99_HUMAN 42.296 331 189 2 309 637 12 342 2.29E-68 234 CFA99_HUMAN reviewed Cilia- and flagella-associated protein 99 CFAP99 Homo sapiens (Human) 459 0 GO:0042995 0 0 0 0 O60500 CHOYP_DGRI_GH23100.1.1 m.44142 sp NPHN_HUMAN 30.157 1018 645 25 25 1005 34 1022 2.29E-135 449 NPHN_HUMAN reviewed Nephrin (Renal glomerulus-specific cell adhesion receptor) NPHS1 NPHN Homo sapiens (Human) 1241 cell adhesion [GO:0007155]; excretion [GO:0007588]; glomerular basement membrane development [GO:0032836]; glomerular visceral epithelial cell development [GO:0072015]; JNK cascade [GO:0007254]; myoblast fusion [GO:0007520]; positive regulation of actin filament polymerization [GO:0030838]; protein localization to synapse [GO:0035418]; regulation of excretion [GO:0044062]; skeletal muscle tissue development [GO:0007519] GO:0005622; GO:0005886; GO:0005887; GO:0007155; GO:0007254; GO:0007519; GO:0007520; GO:0007588; GO:0017022; GO:0030838; GO:0032836; GO:0035418; GO:0036057; GO:0042995; GO:0044062; GO:0070062; GO:0072015 0 0 0 PF08205;PF00041;PF07686; P10039 CHOYP_BM1_33760.1.1 m.37089 sp TENA_CHICK 37.43 179 97 6 129 303 1580 1747 2.29E-21 99 TENA_CHICK reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) 1808 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041;PF12661; P10394 CHOYP_POL.1.1 m.35848 sp POL4_DROME 25.789 190 114 5 1 180 1065 1237 2.29E-10 63.5 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P23403 CHOYP_RS20.1.1 m.46300 sp RS20_XENLA 90.909 110 8 2 4 111 3 112 2.29E-64 194 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P23469 CHOYP_LOC579946.9.24 m.41011 sp PTPRE_HUMAN 33.445 598 337 19 1159 1718 115 689 2.29E-81 287 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P39022 CHOYP_RAD52.1.1 m.13822 sp RAD52_CHICK 64.362 188 67 0 2 189 25 212 2.29E-82 265 RAD52_CHICK reviewed DNA repair protein RAD52 homolog RAD52 Gallus gallus (Chicken) 422 DNA recombinase assembly [GO:0000730]; double-strand break repair via single-strand annealing [GO:0045002] GO:0000730; GO:0003677; GO:0005634; GO:0045002 0 0 0 PF04098; P41778 CHOYP_NAEGRDRAFT_79931.1.1 m.6690 sp PBX1_MOUSE 47.17 53 28 0 533 585 238 290 2.29E-08 60.5 PBX1_MOUSE reviewed Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) Pbx1 Pbx-1 Mus musculus (Mouse) 430 adrenal gland development [GO:0030325]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic hemopoiesis [GO:0035162]; embryonic limb morphogenesis [GO:0030326]; embryonic organ development [GO:0048568]; embryonic skeletal system development [GO:0048706]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; organ morphogenesis [GO:0009887]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proximal/distal pattern formation [GO:0009954]; regulation of cell proliferation [GO:0042127]; regulation of ossification [GO:0030278]; sex differentiation [GO:0007548]; spleen development [GO:0048536]; steroid biosynthetic process [GO:0006694]; thymus development [GO:0048538]; urogenital system development [GO:0001655] GO:0000978; GO:0001077; GO:0001655; GO:0001658; GO:0003677; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006694; GO:0007548; GO:0008284; GO:0009887; GO:0009952; GO:0009954; GO:0010971; GO:0030278; GO:0030325; GO:0030326; GO:0035162; GO:0042127; GO:0043433; GO:0043565; GO:0045665; GO:0045944; GO:0046982; GO:0048536; GO:0048538; GO:0048568; GO:0048706 0 0 0 PF00046;PF03792; P47911 CHOYP_LOC100186361.3.3 m.66600 sp RL6_MOUSE 63.5 200 69 2 153 351 100 296 2.29E-78 245 RL6_MOUSE reviewed 60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) Rpl6 Mus musculus (Mouse) 296 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; Q01528 CHOYP_HAAF.1.13 m.3331 sp HAAF_LIMPO 35.393 178 104 4 1 175 1 170 2.29E-32 118 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q12893 CHOYP_ISCW_ISCW018298.1.1 m.741 sp TM115_HUMAN 47.605 334 166 5 10 340 9 336 2.29E-100 303 TM115_HUMAN reviewed Transmembrane protein 115 (Placental protein 6) (Protein PL6) TMEM115 PL6 LUCA11.2 Homo sapiens (Human) 351 "ER to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of cell proliferation [GO:0008285]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005634; GO:0005794; GO:0006486; GO:0006888; GO:0006890; GO:0008285; GO:0015031; GO:0016021; GO:0032580; GO:0042802 0 0 0 PF08551; Q495T6 CHOYP_MMEL1.3.3 m.42931 sp MMEL1_HUMAN 37.83 682 400 10 117 780 87 762 2.29E-148 457 MMEL1_HUMAN reviewed "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) 779 0 GO:0004222; GO:0005576; GO:0016021; GO:0046872 0 0 cd08662; PF01431;PF05649; Q4VBI7 CHOYP_STX18.2.2 m.51179 sp STX18_DANRE 50.456 329 141 4 2 326 3 313 2.29E-108 321 STX18_DANRE reviewed Syntaxin-18 stx18 zgc:112326 Danio rerio (Zebrafish) (Brachydanio rerio) 314 "ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0005783; GO:0005789; GO:0006886; GO:0006888; GO:0006890; GO:0016021; GO:0031201; GO:0061025 0 0 0 PF10496; Q502M6 CHOYP_LOC100641729.5.10 m.32994 sp ANR29_DANRE 40.164 122 69 1 2 119 79 200 2.29E-24 97.4 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q502M6 CHOYP_TVAG_123950.8.31 m.32928 sp ANR29_DANRE 38.312 154 93 2 4 156 43 195 2.29E-28 109 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q58NQ4 CHOYP_LOC100882444.1.1 m.58415 sp FOXP1_CHICK 43.091 427 178 11 364 785 225 591 2.29E-91 308 FOXP1_CHICK reviewed Forkhead box protein P1 FOXP1 Gallus gallus (Chicken) 686 "cardiac muscle cell differentiation [GO:0055007]; immunoglobulin V(D)J recombination [GO:0033152]; interleukin-21 secretion [GO:0072619]; lung secretory cell differentiation [GO:0061140]; motor neuron axon guidance [GO:0008045]; negative regulation of lung goblet cell differentiation [GO:1901250]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pre-B cell differentiation [GO:0002329]; regulation of cardiac muscle cell proliferation [GO:0060043]; sarcomere organization [GO:0045214]; skeletal muscle tissue development [GO:0007519]; smooth muscle tissue development [GO:0048745]; T follicular helper cell differentiation [GO:0061470]; transcription, DNA-templated [GO:0006351]; ventral spinal cord development [GO:0021517]" GO:0000122; GO:0000978; GO:0000981; GO:0002053; GO:0002329; GO:0002639; GO:0003682; GO:0003705; GO:0005634; GO:0006351; GO:0007519; GO:0008045; GO:0021517; GO:0033152; GO:0045214; GO:0045893; GO:0045944; GO:0046872; GO:0048745; GO:0050679; GO:0055007; GO:0060043; GO:0061140; GO:0061470; GO:0072619; GO:1901250; GO:2000727 0 0 0 PF00250;PF16159; Q5BLD8 CHOYP_CG057.1.1 m.45913 sp MT21A_DANRE 52.229 157 74 1 15 170 53 209 2.29E-51 166 MT21A_DANRE reviewed Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (Methyltransferase-like protein 21A) mettl21a Fam119a zgc:110528 Danio rerio (Zebrafish) (Brachydanio rerio) 218 protein methylation [GO:0006479] GO:0005737; GO:0006479; GO:0016279 0 0 0 PF10294; Q60809 CHOYP_CNOT7.1.2 m.7497 sp CNOT7_MOUSE 78.467 274 55 2 11 280 12 285 2.29E-159 448 CNOT7_MOUSE reviewed CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1) (CAF-1) Cnot7 Caf1 Mus musculus (Mouse) 285 "cytoplasmic mRNA processing body assembly [GO:0033962]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene silencing by RNA [GO:0031047]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000175; GO:0000289; GO:0000290; GO:0000932; GO:0003723; GO:0004532; GO:0004535; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006417; GO:0008284; GO:0008285; GO:0010629; GO:0016020; GO:0030014; GO:0031047; GO:0033962; GO:0043928; GO:0045944; GO:0046872; GO:0060213; GO:0061014; GO:1900153 0 0 0 PF04857; Q60809 CHOYP_CNOT7.2.2 m.35719 sp CNOT7_MOUSE 78.467 274 55 2 11 280 12 285 2.29E-159 448 CNOT7_MOUSE reviewed CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1) (CAF-1) Cnot7 Caf1 Mus musculus (Mouse) 285 "cytoplasmic mRNA processing body assembly [GO:0033962]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene silencing by RNA [GO:0031047]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000175; GO:0000289; GO:0000290; GO:0000932; GO:0003723; GO:0004532; GO:0004535; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006417; GO:0008284; GO:0008285; GO:0010629; GO:0016020; GO:0030014; GO:0031047; GO:0033962; GO:0043928; GO:0045944; GO:0046872; GO:0060213; GO:0061014; GO:1900153 0 0 0 PF04857; Q67FQ3 CHOYP_ARH.1.2 m.5577 sp ARHB_XENLA 59.341 91 37 0 1 91 77 167 2.29E-30 117 ARHB_XENLA reviewed Low density lipoprotein receptor adapter protein 1-B (Autosomal recessive hypercholesterolemia protein homolog beta) (ARH beta) (xARH beta) ldlrap1-b Xenopus laevis (African clawed frog) 309 cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897] GO:0005737; GO:0006897; GO:0008203 0 0 0 PF00640; Q6DIP5 CHOYP_BRAFLDRAFT_105074.2.2 m.50867 sp EMAL4_XENTR 49.254 67 31 1 11 77 6 69 2.29E-07 52.4 EMAL4_XENTR reviewed Echinoderm microtubule-associated protein-like 4 (EMAP-4) eml4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 928 0 GO:0005737; GO:0005874 0 0 0 PF03451;PF00400; Q6R7G0 CHOYP_PMAR_PMAR027405.1.1 m.11717 sp Y068_OSHVF 20.864 671 442 16 22 606 25 692 2.29E-38 156 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6X936 CHOYP_KIRR1.1.1 m.8108 sp KIRR1_RAT 29.812 691 427 17 11 667 35 701 2.29E-81 278 KIRR1_RAT reviewed Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Kirrel Kirrel1 Neph1 Rattus norvegicus (Rat) 789 excretion [GO:0007588]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of actin filament polymerization [GO:0030838]; single organismal cell-cell adhesion [GO:0016337] GO:0001933; GO:0005911; GO:0007588; GO:0016021; GO:0016337; GO:0030838; GO:0031253; GO:0043198; GO:0045121; GO:0048471; GO:0070062 0 0 0 PF08205;PF07679; Q6ZRF8 CHOYP_LOC100374741.36.83 m.32975 sp RN207_HUMAN 20.976 205 147 6 2 204 103 294 2.29E-10 66.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7M3Y3 CHOYP_RN45S.4.5 m.43162 sp TNNI_CHLNI 68.067 119 34 2 240 354 159 277 2.29E-38 142 TNNI_CHLNI reviewed Troponin I (TnI) 0 Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) 292 0 GO:0005861; GO:0046872 0 0 0 PF00992; Q7TQP3 CHOYP_LOC100378392.1.1 m.49074 sp GP119_MOUSE 29.31 290 186 9 48 327 10 290 2.29E-32 126 GP119_MOUSE reviewed Glucose-dependent insulinotropic receptor (G-protein coupled receptor 119) Gpr119 Mus musculus (Mouse) 335 insulin secretion [GO:0030073] GO:0004930; GO:0005886; GO:0008289; GO:0016021; GO:0030073; GO:0031210; GO:0043235 0 0 0 PF00001; Q80WN9 CHOYP_MGC52827.1.1 m.21030 sp B4GT2_CRIGR 43.609 266 143 3 85 346 97 359 2.29E-74 238 B4GT2_CRIGR reviewed "Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2) (Beta4Gal-T2) (b4Gal-T2) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]" B4GALT2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 369 protein glycosylation [GO:0006486] GO:0003831; GO:0003945; GO:0004461; GO:0006486; GO:0016021; GO:0032580; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02709;PF13733; Q86UY8 CHOYP_LOC100376076.1.1 m.8740 sp NT5D3_HUMAN 51.339 448 213 2 66 509 80 526 2.29E-165 482 NT5D3_HUMAN reviewed 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase) NT5DC3 GNN TU12B1-TY Homo sapiens (Human) 548 0 GO:0005739; GO:0005829; GO:0008253; GO:0043235; GO:0046872 0 0 0 PF05761; Q86XE3 CHOYP_CG4662.1.1 m.44483 sp MICU3_HUMAN 48.529 408 174 5 92 470 129 529 2.29E-117 357 MICU3_HUMAN reviewed "Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)" MICU3 EFHA2 Homo sapiens (Human) 530 0 GO:0005509; GO:0005739; GO:0016021 0 0 0 PF13833; Q8C7M3 CHOYP_LOC100374741.28.83 m.31750 sp TRIM9_MOUSE 25.604 207 128 8 32 212 167 373 2.29E-07 57 TRIM9_MOUSE reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) Trim9 Kiaa0282 Mus musculus (Mouse) 817 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; synaptic vesicle exocytosis [GO:0016079] GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016079; GO:0016874; GO:0030054; GO:0030425; GO:0042803; GO:0043161 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643; Q8IDX6 CHOYP_LOC100199980.2.2 m.62744 sp RBP2A_PLAF7 40.541 148 65 5 361 490 2740 2882 2.29E-13 78.2 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8K211 CHOYP_LOC100371434.1.1 m.38875 sp COPT1_MOUSE 32.237 152 82 7 2 146 44 181 2.29E-08 54.7 COPT1_MOUSE reviewed High affinity copper uptake protein 1 (Copper transporter 1) (CTR1) (Solute carrier family 31 member 1) Slc31a1 Mus musculus (Mouse) 196 cellular copper ion homeostasis [GO:0006878]; cellular response to cisplatin [GO:0072719]; copper ion import [GO:0015677]; copper ion import into cell [GO:1902861]; drug transmembrane transport [GO:0006855] GO:0005770; GO:0005886; GO:0006855; GO:0006878; GO:0015088; GO:0015677; GO:0016021; GO:0043025; GO:0055037; GO:0072719; GO:1902861 0 0 0 PF04145; Q8QGW7 CHOYP_LOC100209491.1.2 m.7345 sp LITAF_CHICK 39.103 156 76 5 3 157 11 148 2.29E-20 84.7 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8QGW7 CHOYP_NEMVEDRAFT_V1G169772.1.2 m.30147 sp LITAF_CHICK 43.182 132 65 5 13 142 25 148 2.29E-21 86.7 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8VEG6 CHOYP_LOC100869625.1.1 m.52959 sp CNO6L_MOUSE 60.714 364 139 1 498 857 172 535 2.29E-160 483 CNO6L_MOUSE reviewed CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) Cnot6l Mus musculus (Mouse) 555 "gene silencing by RNA [GO:0031047]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000288; GO:0004535; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006397; GO:0008284; GO:0010606; GO:0030014; GO:0031047; GO:0046872; GO:0061157 0 0 0 PF03372;PF13855; Q96MG7 CHOYP_BRAFLDRAFT_226989.1.1 m.16995 sp NSE3_HUMAN 41.379 232 123 4 21 251 71 290 2.29E-50 170 NSE3_HUMAN reviewed Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) NSMCE3 HCA4 MAGEG1 NDNL2 Homo sapiens (Human) 304 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of protein ubiquitination [GO:0031398]; protein sumoylation [GO:0016925]; regulation of growth [GO:0040008] GO:0000781; GO:0005654; GO:0005737; GO:0006281; GO:0006310; GO:0016925; GO:0030915; GO:0031398; GO:0040008 0 0 0 PF01454; Q99020 CHOYP_ROAA.6.6 m.65751 sp ROAA_MOUSE 55.422 166 73 1 53 218 70 234 2.29E-56 187 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q9D7A8 CHOYP_BRAFLDRAFT_87849.1.1 m.8469 sp ARMC1_MOUSE 35.448 268 166 5 21 287 21 282 2.29E-51 173 ARMC1_MOUSE reviewed Armadillo repeat-containing protein 1 Armc1 Mus musculus (Mouse) 282 metal ion transport [GO:0030001] GO:0005634; GO:0005739; GO:0030001; GO:0046872 0 0 0 PF00514; Q9GKY8 CHOYP_LOC662408.1.1 m.44393 sp JPH1_RABIT 51.653 484 199 7 5 485 3 454 2.29E-150 458 JPH1_RABIT reviewed Junctophilin-1 (JP-1) (Junctophilin type 1) (Mitsugumin-72) (Mg72) JPH1 JP1 MG72 Oryctolagus cuniculus (Rabbit) 662 0 GO:0005886; GO:0016021; GO:0030314; GO:0033017 0 0 0 PF02493; Q9H8W5 CHOYP_BRAFLDRAFT_128153.5.5 m.64221 sp TRI45_HUMAN 34.783 92 51 4 52 138 135 222 2.29E-06 53.5 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9QXM0 CHOYP_ABHD2.2.2 m.32276 sp ABHD2_MOUSE 45.269 391 210 2 3 390 15 404 2.29E-118 362 ABHD2_MOUSE reviewed Monoacylglycerol lipase ABHD2 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 2) (Lung alpha/beta hydrolase 2) (MmLABH2) Abhd2 Labh-2 Labh2 Mus musculus (Mouse) 425 acrosome reaction [GO:0007340]; acylglycerol catabolic process [GO:0046464]; negative regulation of cell migration [GO:0030336]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; sperm capacitation [GO:0048240]; steroid hormone mediated signaling pathway [GO:0043401] GO:0001669; GO:0002080; GO:0003707; GO:0007340; GO:0009611; GO:0016021; GO:0030336; GO:0032570; GO:0036126; GO:0042562; GO:0043401; GO:0046464; GO:0047372; GO:0048240; GO:0097524 0 0 0 PF00561; A0A0R4IBK5 CHOYP_BRAFLDRAFT_106560.11.14 m.48029 sp R213A_DANRE 25.872 889 493 35 107 864 1898 2751 2.30E-50 197 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A4IF63 CHOYP_TRIM3.48.58 m.50765 sp TRIM2_BOVIN 36.364 88 54 2 20 106 621 707 2.30E-11 62 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6QQY2 CHOYP_LOC556381.1.1 m.45398 sp KLH13_BOVIN 29.577 142 90 3 129 270 388 519 2.30E-13 73.2 KLH13_BOVIN reviewed Kelch-like protein 13 KLHL13 Bos taurus (Bovine) 655 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; A7MCS3 CHOYP_BRAFLDRAFT_66659.1.2 m.2451 sp CP089_DANRE 23.823 361 225 6 21 376 23 338 2.30E-29 119 CP089_DANRE reviewed UPF0764 protein C16orf89 homolog 0 Danio rerio (Zebrafish) (Brachydanio rerio) 351 0 GO:0005576 0 0 0 PF15882; I3LM39 CHOYP_LOC100375194.7.7 m.58359 sp CGAS_PIG 28.022 182 107 7 61 223 305 481 2.30E-06 52.4 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O42603 CHOYP_LOC100680142.1.1 m.14913 sp CRFR2_XENLA 32.843 408 241 12 16 408 2 391 2.30E-57 202 CRFR2_XENLA reviewed Corticotropin-releasing factor receptor 2 (CRF-R-2) (CRF-R2) (CRFR-2) (Corticotropin-releasing hormone receptor 2) (CRH-R-2) (CRH-R2) crhr2 crf2 Xenopus laevis (African clawed frog) 413 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021 0 0 0 PF00002;PF02793; O76756 CHOYP_DYN1.2.3 m.30773 sp RS8_APIME 73.292 161 41 1 2 162 50 208 2.30E-80 239 RS8_APIME reviewed 40S ribosomal protein S8 RpS8 Apis mellifera (Honeybee) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; P0CT33 CHOYP_RQSIM.1.1 m.61486 sp TLH1_SCHPO 39.683 63 38 0 29 91 1467 1529 2.30E-09 56.2 TLH1_SCHPO reviewed ATP-dependent DNA helicase tlh1 (EC 3.6.4.12) (Sub-telomeric helicase RecQ homolog 1) (Fragment) tlh1 SPAC212.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1887 base-excision repair [GO:0006284]; cell aging [GO:0007569]; cellular response to gamma radiation [GO:0071480]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; replication fork processing [GO:0031297]; telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000731; GO:0000784; GO:0003677; GO:0005524; GO:0005654; GO:0005737; GO:0006284; GO:0006302; GO:0007569; GO:0008270; GO:0009378; GO:0031297; GO:0043140; GO:0071480 0 0 0 PF00270;PF00271; P29503 CHOYP_AGAP_AGAP001999.1.1 m.17856 sp NEUR_DROME 41.966 417 201 7 91 469 106 519 2.30E-110 352 NEUR_DROME reviewed Protein neuralized neur neu CG11988 Drosophila melanogaster (Fruit fly) 754 asymmetric cell division [GO:0008356]; brain morphogenesis [GO:0048854]; compound eye development [GO:0048749]; ectoderm development [GO:0007398]; germ-line stem cell population maintenance [GO:0030718]; imaginal disc-derived wing morphogenesis [GO:0007476]; inter-male aggressive behavior [GO:0002121]; lateral inhibition [GO:0046331]; locomotion involved in locomotory behavior [GO:0031987]; long-term memory [GO:0007616]; mesoderm development [GO:0007498]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; olfactory behavior [GO:0042048]; ovarian follicle cell development [GO:0030707]; peripheral nervous system development [GO:0007422]; positive regulation of Notch signaling pathway [GO:0045747]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; regulation of compound eye photoreceptor development [GO:0045314]; regulation of Notch signaling pathway [GO:0008593]; regulation of photoreceptor cell differentiation [GO:0046532]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]; startle response [GO:0001964]; ventral cord development [GO:0007419] GO:0000209; GO:0001964; GO:0002121; GO:0003677; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007219; GO:0007398; GO:0007399; GO:0007419; GO:0007422; GO:0007423; GO:0007476; GO:0007498; GO:0007616; GO:0008104; GO:0008270; GO:0008356; GO:0008593; GO:0016360; GO:0030707; GO:0030718; GO:0031987; GO:0042048; GO:0045314; GO:0045747; GO:0046331; GO:0046532; GO:0048471; GO:0048749; GO:0048854; GO:0051260; GO:0061630; GO:1901981 0 0 0 PF07177; P41383 CHOYP_RABGAP1.1.1 m.50533 sp TBA2_PATVU 97.908 239 5 0 5 243 214 452 2.30E-176 495 TBA2_PATVU reviewed Tubulin alpha-2/alpha-4 chain TUB2; TUB4 Patella vulgata (Common limpet) 452 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P54001 CHOYP_LOC100372889.1.2 m.37506 sp P4HA1_RAT 24.474 523 314 17 42 508 23 520 2.30E-22 103 P4HA1_RAT reviewed "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4ha1 P4ha Rattus norvegicus (Rat) 534 collagen fibril organization [GO:0030199]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401] GO:0004656; GO:0005506; GO:0005739; GO:0005788; GO:0016020; GO:0016222; GO:0016702; GO:0018401; GO:0030199; GO:0031418 0 0 0 PF13640;PF08336; P62155 CHOYP_CALM.42.50 m.56135 sp CALM_XENLA 90.265 113 11 0 1 113 37 149 2.30E-70 209 CALM_XENLA reviewed Calmodulin (CaM) calm1; calm2 Xenopus laevis (African clawed frog) 149 0 GO:0005102; GO:0005509 0 0 0 PF13499; Q0E908 CHOYP_BRAFLDRAFT_69505.2.4 m.27771 sp HIL_DROME 25.472 212 142 6 49 259 338 534 2.30E-17 84.7 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q12951 CHOYP_LOC100313609.1.1 m.14915 sp FOXI1_HUMAN 55.67 97 41 1 76 170 123 219 2.30E-31 122 FOXI1_HUMAN reviewed Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead-related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HFH-3) (HNF-3/fork-head homolog 3) FOXI1 FKHL10 FREAC6 Homo sapiens (Human) 378 embryo development [GO:0009790]; inner ear morphogenesis [GO:0042472]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0003700; GO:0005634; GO:0008301; GO:0009790; GO:0042472; GO:0043565; GO:0044212; GO:0045944 0 0 0 PF00250; Q15149 CHOYP_LOC100903812.1.1 m.65786 sp PLEC_HUMAN 24.715 263 177 7 203 452 829 1083 2.30E-14 81.6 PLEC_HUMAN reviewed Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) PLEC PLEC1 Homo sapiens (Human) 4684 hemidesmosome assembly [GO:0031581] GO:0005737; GO:0005829; GO:0005886; GO:0005903; GO:0005913; GO:0005925; GO:0008307; GO:0016528; GO:0030056; GO:0030506; GO:0031012; GO:0031581; GO:0042383; GO:0043034; GO:0044822; GO:0045111; GO:0070062; GO:0098641 0 0 0 PF00307;PF00681;PF03501; Q39575 CHOYP_LOC577805.4.4 m.55432 sp DYHG_CHLRE 28.347 829 507 12 567 1393 472 1215 2.30E-102 365 DYHG_CHLRE reviewed "Dynein gamma chain, flagellar outer arm" ODA2 ODA-2 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4485 cilium movement involved in cell motility [GO:0060294]; outer dynein arm assembly [GO:0036158] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0016887; GO:0030286; GO:0031514; GO:0036158; GO:0060294 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q3SX45 CHOYP_ASB2.3.3 m.65364 sp ASB2_BOVIN 30.622 209 116 7 591 773 150 355 2.30E-10 67.8 ASB2_BOVIN reviewed Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) 633 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q3UN58 CHOYP_RSRC2.1.1 m.14845 sp FAP20_MOUSE 31.25 144 80 4 71 212 60 186 2.30E-09 58.2 FAP20_MOUSE reviewed Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa) Faap20 Mus musculus (Mouse) 186 cellular response to DNA damage stimulus [GO:0006974]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985] GO:0005654; GO:0005694; GO:0006974; GO:0019985; GO:0030054; GO:0031593; GO:0036297; GO:0043130; GO:0043240; GO:0046872; GO:0070530 0 0 0 PF15751;PF15750; Q4KMD7 CHOYP_LOC100375897.1.2 m.14439 sp STPAP_DANRE 28.881 554 308 9 43 575 16 504 2.30E-65 239 STPAP_DANRE reviewed Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) tut1 rbm21 zgc:112254 Danio rerio (Zebrafish) (Brachydanio rerio) 797 mRNA polyadenylation [GO:0006378]; pre-mRNA cleavage required for polyadenylation [GO:0098789]; snRNA processing [GO:0016180] GO:0003723; GO:0003730; GO:0004652; GO:0005524; GO:0005730; GO:0006378; GO:0008270; GO:0016180; GO:0016607; GO:0050265; GO:0098789 0 0 0 PF03828;PF00076; Q5TZ51 CHOYP_LOC100905089.2.2 m.16614 sp MPV17_DANRE 36.571 175 108 2 1 172 1 175 2.30E-35 126 MPV17_DANRE reviewed Protein Mpv17 mpv17 zgc:63573 Danio rerio (Zebrafish) (Brachydanio rerio) 177 0 GO:0005743; GO:0016021 0 0 0 PF04117; Q5UQG7 CHOYP_YR826.1.1 m.62280 sp YR818_MIMIV 30.743 296 172 8 336 631 1388 1650 2.30E-37 153 YR818_MIMIV reviewed Putative serine/threonine-protein kinase/receptor R818 (EC 2.7.11.1) MIMI_R818 Acanthamoeba polyphaga mimivirus (APMV) 1651 cyclic nucleotide biosynthetic process [GO:0009190]; intracellular signal transduction [GO:0035556] GO:0004674; GO:0005524; GO:0009190; GO:0016021; GO:0016849; GO:0035556 0 0 0 PF00211;PF12849;PF07714; Q654D9 CHOYP_ISCW_ISCW000333.1.1 m.7456 sp CSTR1_ORYSJ 28.859 298 189 9 27 315 16 299 2.30E-29 118 CSTR1_ORYSJ reviewed CMP-sialic acid transporter 1 (CMP-SA-Tr 1) (CMP-Sia-Tr 1) (CMP-sialic acid transporter-like protein 1) (OsCSTLP1) CSTLP1 Os06g0523400 LOC_Os06g33210 OsJ_21524 OSJNBa0009J19.27 Oryza sativa subsp. japonica (Rice) 322 sialic acid transport [GO:0015739] GO:0000139; GO:0005351; GO:0015136; GO:0015739; GO:0016021 0 0 0 PF04142; Q66JG3 CHOYP_DMOJ_GI16866.1.1 m.10282 sp SYEM_XENTR 45.759 507 252 8 23 524 25 513 2.30E-151 446 SYEM_XENTR reviewed "Probable glutamate--tRNA ligase, mitochondrial (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS)" ears2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 516 glutamyl-tRNA aminoacylation [GO:0006424]; tRNA aminoacylation for mitochondrial protein translation [GO:0070127] GO:0000049; GO:0003723; GO:0004818; GO:0005524; GO:0005739; GO:0005759; GO:0006424; GO:0070127 0 0 0 PF00749; Q6B855 CHOYP_LOC101069588.1.1 m.34189 sp TKT_BOVIN 63.462 312 108 3 1 311 1 307 2.30E-141 416 TKT_BOVIN reviewed Transketolase (TK) (EC 2.2.1.1) TKT TKT1 Bos taurus (Bovine) 623 metabolic process [GO:0008152]; regulation of growth [GO:0040008] GO:0004802; GO:0008152; GO:0040008; GO:0046872 0 0 0 PF02779;PF02780;PF00456; Q6MG82 CHOYP_contig_047066 m.55375 sp PRRT1_RAT 41.497 147 71 4 72 208 159 300 2.30E-16 79 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6P823 CHOYP_BRAFLDRAFT_117811.1.1 m.27128 sp H33_XENTR 100 136 0 0 1 136 1 136 2.30E-95 273 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q6P823 CHOYP_BRAFLDRAFT_124122.1.1 m.61428 sp H33_XENTR 100 136 0 0 1 136 1 136 2.30E-95 273 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q6P823 CHOYP_H33.1.5 m.2724 sp H33_XENTR 100 136 0 0 1 136 1 136 2.30E-95 273 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q6P823 CHOYP_H33.2.5 m.12190 sp H33_XENTR 100 136 0 0 1 136 1 136 2.30E-95 273 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q6P823 CHOYP_H33.4.5 m.59687 sp H33_XENTR 100 136 0 0 1 136 1 136 2.30E-95 273 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q6P823 CHOYP_STK11.1.1 m.19140 sp H33_XENTR 100 136 0 0 1 136 1 136 2.30E-95 273 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q6TFL4 CHOYP_KLH24.2.6 m.24950 sp KLH24_HUMAN 27.818 550 367 10 49 595 66 588 2.30E-65 228 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q75JP5 CHOYP_TRIADDRAFT_51343.2.2 m.65118 sp Y2471_DICDI 26.237 465 279 21 3724 4166 595 1017 2.30E-17 94.4 Y2471_DICDI reviewed Calponin homology domain-containing protein DDB_G0272472 DDB_G0272472 Dictyostelium discoideum (Slime mold) 1508 0 0 0 0 0 PF00307; Q7TNF8 CHOYP_RIMB2.4.5 m.24234 sp RIMB1_MOUSE 31.544 913 499 25 1 865 237 1071 2.30E-103 367 RIMB1_MOUSE reviewed Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) Tspoap1 Bzrap1 Kiaa0612 Rbp1 Mus musculus (Mouse) 1846 0 GO:0005737; GO:0005739; GO:0030156 0 0 0 PF07653;PF14604; Q7W977 CHOYP_LOC100641267.2.2 m.57947 sp ECTD_BORPA 23.622 254 167 7 7 237 27 276 2.30E-14 75.1 ECTD_BORPA reviewed Ectoine dioxygenase (EC 1.14.11.-) (Ectoine hydroxylase) ectD BPP1891 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 308 ectoine catabolic process [GO:0042400] GO:0005506; GO:0016706; GO:0042400 0 0 0 PF05721; Q8CHS8 CHOYP_CNOT7.2.2 m.35718 sp VP37A_MOUSE 32.99 388 224 6 1 352 1 388 2.30E-58 197 VP37A_MOUSE reviewed Vacuolar protein sorting-associated protein 37A (Vps37A) (ESCRT-I complex subunit VPS37A) Vps37a Mus musculus (Mouse) 397 protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] GO:0000813; GO:0005654; GO:0005737; GO:0005813; GO:0015031; GO:0031902; GO:0043162; GO:0043231 0 0 0 PF07200; Q8VDN4 CHOYP_LOC100767201.1.1 m.20318 sp CCD92_MOUSE 32.639 288 162 12 15 275 16 298 2.30E-23 100 CCD92_MOUSE reviewed Coiled-coil domain-containing protein 92 Ccdc92 D5Bwg0834e Mus musculus (Mouse) 314 0 GO:0005814 0 0 0 0 Q91YD4 CHOYP_TRPM6.2.2 m.54017 sp TRPM2_MOUSE 27.607 489 278 14 606 1051 620 1075 2.30E-40 167 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q95M12 CHOYP_LOC100182585.2.2 m.24666 sp LGMN_BOVIN 46.667 435 219 7 34 465 5 429 2.30E-131 389 LGMN_BOVIN reviewed "Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)" LGMN PRSC1 Bos taurus (Bovine) 433 negative regulation of ERBB signaling pathway [GO:1901185]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; receptor catabolic process [GO:0032801]; renal system process [GO:0003014]; vacuolar protein processing [GO:0006624] GO:0003014; GO:0004197; GO:0005764; GO:0006508; GO:0006624; GO:0032801; GO:0051603; GO:1901185 0 0 0 PF01650; Q9C040 CHOYP_TRIM3.32.58 m.33665 sp TRIM2_HUMAN 34.437 151 83 3 6 156 12 146 2.30E-19 96.3 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9D7K5 CHOYP_AT5SL.1.1 m.43743 sp AT5SL_MOUSE 41.304 92 50 1 1 88 162 253 2.30E-14 69.7 AT5SL_MOUSE reviewed ATP synthase subunit s-like protein Atp5sl Mus musculus (Mouse) 258 0 GO:0005739 0 0 0 0 Q9NUV9 CHOYP_LOC570473.1.1 m.45974 sp GIMA4_HUMAN 39.925 268 149 4 72 339 30 285 2.30E-57 196 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9P2J9 CHOYP_PDP2.1.2 m.19324 sp PDP2_HUMAN 40.625 192 94 6 2 178 313 499 2.30E-30 118 PDP2_HUMAN reviewed "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2)" PDP2 KIAA1348 Homo sapiens (Human) 529 regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510] GO:0004724; GO:0004741; GO:0005759; GO:0010510; GO:0046872 0 0 0 PF00481; Q9U9K0 CHOYP_ADD.4.5 m.47341 sp ADD1_CAEEL 54 50 23 0 21 70 16 65 2.30E-11 61.6 ADD1_CAEEL reviewed Adducin-related protein 1 add-1 F39C12.2 Caenorhabditis elegans 732 barbed-end actin filament capping [GO:0051016]; long-term memory [GO:0007616]; memory [GO:0007613]; receptor localization to synapse [GO:0097120]; regulation of actin cytoskeleton reorganization [GO:2000249]; short-term memory [GO:0007614] GO:0005737; GO:0005856; GO:0005886; GO:0007613; GO:0007614; GO:0007616; GO:0014069; GO:0051015; GO:0051016; GO:0097120; GO:2000249 0 0 0 PF00596; Q9WU56 CHOYP_LOC100079978.1.1 m.18519 sp TRUA_MOUSE 47.397 365 183 4 33 393 57 416 2.30E-114 346 TRUA_MOUSE reviewed "tRNA pseudouridine synthase A, mitochondrial (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)" Pus1 MNCb-0873 Mus musculus (Mouse) 423 positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; tRNA pseudouridine synthesis [GO:0031119] GO:0005634; GO:0005667; GO:0005730; GO:0005739; GO:0009982; GO:0030374; GO:0031119; GO:0044822; GO:0045944 0 0 0 PF01416; Q9Z1L3 CHOYP_DEDD.1.1 m.12885 sp DEDD_MOUSE 51.125 311 128 3 17 323 22 312 2.30E-97 293 DEDD_MOUSE reviewed Death effector domain-containing protein (DEDPro1) Dedd Mus musculus (Mouse) 318 "decidualization [GO:0046697]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901837]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005730; GO:0005737; GO:0006351; GO:0007283; GO:0008625; GO:0042177; GO:0042981; GO:0046697; GO:1901837 0 0 0 PF01335; A4IGK3 CHOYP_LOC101167192.1.2 m.16723 sp CRBL2_XENTR 48.052 77 38 1 4 80 10 84 2.31E-17 80.1 CRBL2_XENTR reviewed cAMP-responsive element-binding protein-like 2 crebl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 118 "cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0030154; GO:0043565; GO:0045600; GO:0045893; GO:0046326; GO:0046889 0 0 0 PF07716; B3EWZ5 CHOYP_TRIADDRAFT_53234.1.1 m.53014 sp MLRP1_ACRMI 27.982 218 139 7 69 270 3083 3298 2.31E-15 84 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B7ZC32 CHOYP_LOC100374159.1.2 m.40777 sp KIF28_HUMAN 29.348 276 182 6 30 299 515 783 2.31E-33 138 KIF28_HUMAN reviewed Kinesin-like protein KIF28P (Kinesin-like protein 6) KIF28P KLP6 Homo sapiens (Human) 967 cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384] GO:0003777; GO:0005524; GO:0005622; GO:0005871; GO:0007005; GO:0007018; GO:0016887; GO:0030705; GO:0031966; GO:0072384 0 0 0 PF12423;PF00225; B8JK39 CHOYP_ITA8.2.3 m.58456 sp ITA9_MOUSE 23.099 1039 658 41 20 963 30 1022 2.31E-44 177 ITA9_MOUSE reviewed Integrin alpha-9 Itga9 Mus musculus (Mouse) 1036 cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]; neutrophil chemotaxis [GO:0030593]; wound healing [GO:0042060] GO:0007155; GO:0007229; GO:0009925; GO:0030593; GO:0034679; GO:0042060; GO:0046872 0 0 0 PF01839;PF08441; D2GXS7 CHOYP_BRAFLDRAFT_87295.1.9 m.13203 sp TRIM2_AILME 26.115 157 99 5 106 259 600 742 2.31E-06 52.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E7FAM5 CHOYP_BRAFLDRAFT_87325.7.11 m.31144 sp LIN41_DANRE 33 100 61 2 44 138 576 674 2.31E-07 52.4 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O95847 CHOYP_LOC100697793.6.6 m.63428 sp UCP4_HUMAN 55.208 96 37 2 21 110 22 117 2.31E-23 102 UCP4_HUMAN reviewed Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27) SLC25A27 UCP4 UNQ772/PRO1566 Homo sapiens (Human) 323 generation of precursor metabolites and energy [GO:0006091]; proton transport [GO:0015992]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005743; GO:0006091; GO:0006412; GO:0015992; GO:0016021 0 0 0 PF00153; P02556 CHOYP_LOC373275.4.7 m.47549 sp TBB_LYTPI 96.377 138 5 0 1 138 24 161 2.31E-99 286 TBB_LYTPI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Lytechinus pictus (Painted sea urchin) 177 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P22105 CHOYP_CRE_01395.2.2 m.44269 sp TENX_HUMAN 28.205 663 305 46 57 664 204 750 2.31E-34 144 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P27657 CHOYP_BRAFLDRAFT_236273.1.1 m.3873 sp LIPP_RAT 35.316 269 153 9 70 317 45 313 2.31E-38 145 LIPP_RAT reviewed Pancreatic triacylglycerol lipase (PL) (Pancreatic lipase) (EC 3.1.1.3) Pnlip Rattus norvegicus (Rat) 465 lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; post-embryonic development [GO:0009791]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005615; GO:0006629; GO:0009791; GO:0016042; GO:0016298; GO:0033993; GO:0043434; GO:0046872 0 0 0 PF00151;PF01477; P31674 CHOYP_ISCW_ISCW016148.5.6 m.63054 sp RS15_ORYSJ 81.356 118 22 0 1 118 37 154 2.31E-67 202 RS15_ORYSJ reviewed 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) 154 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00203; P35368 CHOYP_NPY2R.1.1 m.24885 sp ADA1B_HUMAN 25.507 345 215 13 38 370 44 358 2.31E-11 68.6 ADA1B_HUMAN reviewed Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) ADRA1B Homo sapiens (Human) 520 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell-cell signaling [GO:0007267]; cell proliferation [GO:0008283]; glucose homeostasis [GO:0042593]; G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001994]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of vasoconstriction [GO:0045907]; regulation of cardiac muscle contraction [GO:0055117] GO:0001994; GO:0004937; GO:0005634; GO:0005886; GO:0005887; GO:0007186; GO:0007188; GO:0007200; GO:0007204; GO:0007267; GO:0007275; GO:0008283; GO:0031965; GO:0035556; GO:0042593; GO:0043410; GO:0045907; GO:0045987; GO:0046982; GO:0055117; GO:0071880 0 0 0 PF00001; P60204 CHOYP_CALM.8.50 m.21412 sp CALM_EMENI 51.007 149 66 2 2 147 4 148 2.31E-41 138 CALM_EMENI reviewed Calmodulin (CaM) camA cam AN2047 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 149 regulation of cell cycle [GO:0051726]; spore germination [GO:0009847] GO:0001411; GO:0005509; GO:0009847; GO:0051726 0 0 0 PF13499; P62501 CHOYP_TSC22D1.1.1 m.12912 sp T22D1_RAT 72.84 81 22 0 47 127 24 104 2.31E-33 117 T22D1_RAT reviewed TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Tsc22d1 Tgfb1i4 Tsc22 Rattus norvegicus (Rat) 143 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351 0 0 0 PF01166; P62501 CHOYP_TSC22D3.1.1 m.134 sp T22D1_RAT 80.282 71 14 0 42 112 34 104 2.31E-32 114 T22D1_RAT reviewed TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Tsc22d1 Tgfb1i4 Tsc22 Rattus norvegicus (Rat) 143 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351 0 0 0 PF01166; P84316 CHOYP_EF-1A.1.9 m.5614 sp EF1A_HELZE 83.077 195 32 1 1 194 35 229 2.31E-116 339 EF1A_HELZE reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Helicoverpa zea (Corn earworm moth) (Heliothis zea) 413 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; P97608 CHOYP_BRAFLDRAFT_214348.2.2 m.59997 sp OPLA_RAT 58.58 169 67 1 5 173 8 173 2.31E-60 205 OPLA_RAT reviewed 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) Oplah Rattus norvegicus (Rat) 1288 glutathione metabolic process [GO:0006749] GO:0005524; GO:0005829; GO:0006749; GO:0017168 0 0 0 PF05378;PF01968;PF02538; Q13233 CHOYP_LOC100334486.1.1 m.55709 sp M3K1_HUMAN 38.425 635 348 9 9 618 288 904 2.31E-135 437 M3K1_HUMAN reviewed Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) MAP3K1 MAPKKK1 MEKK MEKK1 Homo sapiens (Human) 1512 apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; Fc-epsilon receptor signaling pathway [GO:0038095]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; protein phosphorylation [GO:0006468] GO:0002755; GO:0004672; GO:0004674; GO:0004702; GO:0004709; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006915; GO:0008270; GO:0019901; GO:0038095; GO:0071260 0 0 0 PF00069; Q15262 CHOYP_PTPRC.8.14 m.42347 sp PTPRK_HUMAN 30.22 546 347 13 25 547 904 1438 2.31E-71 252 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q28558 CHOYP_GBLP.7.7 m.66710 sp MTR1L_SHEEP 24.823 423 283 13 20 433 14 410 2.31E-27 118 MTR1L_SHEEP reviewed Melatonin-related receptor (G protein-coupled receptor 50) (H9) GPR50 Ovis aries (Sheep) 575 0 GO:0005886; GO:0008502; GO:0016021 0 0 0 PF00001; Q28C22 CHOYP_LOC752784.1.2 m.45560 sp OGFD2_XENTR 52.616 344 155 3 12 351 9 348 2.31E-130 379 OGFD2_XENTR reviewed 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-) ogfod2 TEgg127j14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 349 0 GO:0005506; GO:0016705; GO:0031418; GO:0051213 0 0 0 0 Q3SZ90 CHOYP_ISCW_ISCW019130.2.2 m.50937 sp RL13A_BOVIN 62.814 199 74 0 52 250 3 201 2.31E-90 268 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q3V2Q8 CHOYP_LOC100373038.1.1 m.20860 sp N42L1_MOUSE 43.689 103 57 1 73 174 40 142 2.31E-23 95.5 N42L1_MOUSE reviewed NEDD4-binding protein 2-like 1 N4bp2l1 Mus musculus (Mouse) 238 0 0 0 0 0 0 Q54KA7 CHOYP_AFUA_1G01020.2.50 m.735 sp SECG_DICDI 42.458 179 102 1 1 178 120 298 2.31E-34 130 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5BIM1 CHOYP_LOC100376121.4.6 m.29336 sp TRI45_BOVIN 25.478 157 114 2 12 166 133 288 2.31E-10 65.1 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5K651 CHOYP_LOC100368251.3.6 m.40053 sp SAMD9_HUMAN 35.294 136 74 4 402 535 182 305 2.31E-13 77 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q5R4M2 CHOYP_ULK4.3.3 m.24671 sp ULK4_PONAB 39.623 689 370 11 1 677 95 749 2.31E-162 503 ULK4_PONAB reviewed Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1275 0 GO:0004674; GO:0005524 0 0 0 PF00069; Q5RL51 CHOYP_LOC100713637.1.1 m.16691 sp GSTCD_MOUSE 33.381 704 352 19 22 705 25 631 2.31E-108 345 GSTCD_MOUSE reviewed Glutathione S-transferase C-terminal domain-containing protein Gstcd Mus musculus (Mouse) 634 0 GO:0005737; GO:0070062 0 0 0 PF14497;PF13679; Q6DG22 CHOYP_ADA.1.1 m.5625 sp ADA_DANRE 46.686 347 178 5 41 385 11 352 2.31E-104 315 ADA_DANRE reviewed Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) ada Danio rerio (Zebrafish) (Brachydanio rerio) 359 adenosine catabolic process [GO:0006154]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; nucleotide metabolic process [GO:0009117]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; T cell activation [GO:0042110] GO:0004000; GO:0005829; GO:0006154; GO:0008270; GO:0009117; GO:0009168; GO:0009897; GO:0030054; GO:0042110; GO:0043103; GO:0046103; GO:0060169; GO:0060205 0 0 0 PF00962; Q6R7G0 CHOYP_contig_006832 m.7796 sp Y068_OSHVF 20.703 512 338 13 25 470 29 538 2.31E-26 116 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q70CQ2 CHOYP_USP34.1.1 m.66316 sp UBP34_HUMAN 48.14 457 212 6 18 455 23 473 2.31E-135 457 UBP34_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) USP34 KIAA0570 KIAA0729 Homo sapiens (Human) 3546 "histone deubiquitination [GO:0016578]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; regulation of transcription, DNA-templated [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]" GO:0000124; GO:0004197; GO:0004843; GO:0005829; GO:0006355; GO:0006511; GO:0016055; GO:0016578; GO:0016579; GO:0071108; GO:0090263 0 0 0 PF00443; Q8SWR3 CHOYP_SPR.3.3 m.41740 sp SPR_DROME 38.333 360 209 7 32 386 84 435 2.31E-79 253 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q99715 CHOYP_COL12A1A.1.1 m.44893 sp COCA1_HUMAN 23.567 471 282 17 61 469 162 616 2.31E-13 76.6 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q99NH0 CHOYP_LOC753709.24.44 m.41548 sp ANR17_MOUSE 34.774 486 269 15 250 722 269 719 2.31E-57 216 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9H6T3 CHOYP_LOC577383.1.1 m.8364 sp RPAP3_HUMAN 37.221 403 219 11 128 508 274 664 2.31E-65 226 RPAP3_HUMAN reviewed RNA polymerase II-associated protein 3 RPAP3 Homo sapiens (Human) 665 0 GO:0097255 0 0 0 PF13877;PF00515;PF13176;PF13181; Q9HCF6 CHOYP_BRAFLDRAFT_70987.2.2 m.58284 sp TRPM3_HUMAN 27.832 715 434 24 143 802 514 1201 2.31E-64 239 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9IA95 CHOYP_SFRP4.1.1 m.61896 sp SFRP3_CHICK 46.931 277 127 6 34 309 27 284 2.31E-79 248 SFRP3_CHICK reviewed Secreted frizzled-related protein 3 (sFRP-3) (Frizzled-related protein 1) (FrzB-1) FRZB SFRP3 Gallus gallus (Chicken) 315 canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of Wnt signaling pathway [GO:0030178]; non-canonical Wnt signaling pathway [GO:0035567] GO:0004930; GO:0005576; GO:0007275; GO:0016021; GO:0017147; GO:0030154; GO:0030178; GO:0035567; GO:0042813; GO:0060070 0 0 0 PF01392;PF01759; Q9NUV9 CHOYP_LOC100149379.1.2 m.49251 sp GIMA4_HUMAN 34.868 304 189 3 29 329 28 325 2.31E-53 181 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9UIU6 CHOYP_LOC100373027.1.1 m.55904 sp SIX4_HUMAN 74.725 182 46 0 136 317 106 287 2.31E-97 310 SIX4_HUMAN reviewed Homeobox protein SIX4 (Sine oculis homeobox homolog 4) SIX4 Homo sapiens (Human) 781 "anatomical structure morphogenesis [GO:0009653]; embryonic cranial skeleton morphogenesis [GO:0048701]; fungiform papilla morphogenesis [GO:0061197]; generation of neurons [GO:0048699]; inner ear morphogenesis [GO:0042472]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; male sex differentiation [GO:0046661]; metanephric mesenchyme development [GO:0072075]; myoblast migration [GO:0051451]; myotome development [GO:0061055]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of satellite cell differentiation [GO:1902725]; negative regulation of transcription, DNA-templated [GO:0045892]; olfactory placode formation [GO:0030910]; pharyngeal system development [GO:0060037]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ureteric bud formation [GO:0072107]; protein localization to nucleus [GO:0034504]; regulation of branch elongation involved in ureteric bud branching [GO:0072095]; regulation of epithelial cell proliferation [GO:0050678]; regulation of protein localization [GO:0032880]; regulation of synaptic growth at neuromuscular junction [GO:0008582]; sarcomere organization [GO:0045214]; skeletal muscle fiber differentiation [GO:0098528]; skeletal muscle tissue development [GO:0007519]; thymus development [GO:0048538]; tongue development [GO:0043586]; trigeminal ganglion development [GO:0061551]" GO:0000978; GO:0001077; GO:0005634; GO:0005737; GO:0007519; GO:0008582; GO:0008584; GO:0009653; GO:0030238; GO:0030910; GO:0032880; GO:0034504; GO:0042472; GO:0043066; GO:0043524; GO:0043586; GO:0045214; GO:0045892; GO:0045893; GO:0046661; GO:0048538; GO:0048699; GO:0048701; GO:0050678; GO:0051451; GO:0060037; GO:0061055; GO:0061197; GO:0061551; GO:0072075; GO:0072095; GO:0072107; GO:0090190; GO:0098528; GO:1902725 0 0 0 PF00046;PF16878; Q9UTR8 CHOYP_ZFC3H1.2.2 m.16737 sp YLP3_SCHPO 42.857 77 43 1 1251 1326 579 655 2.31E-12 76.3 YLP3_SCHPO reviewed Protein red1 (RNA elimination defective protein 1) red1 SPAC1006.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 712 "negative regulation of meiotic cell cycle [GO:0051447]; nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts [GO:0033621]; regulation of heterochromatin domain assembly [GO:1902802]; regulation of heterochromatin island assembly [GO:1902801]; regulation of snoRNA processing [GO:1902796]" GO:0005634; GO:0016604; GO:0033621; GO:0046872; GO:0051447; GO:1902796; GO:1902801; GO:1902802; GO:1990251; GO:1990342; GO:1990345; GO:1990477 0 0 0 PF10650; Q9VCA2 CHOYP_AAEL_AAEL012443.1.1 m.51690 sp ORCT_DROME 35.599 559 323 6 1 548 1 533 2.31E-106 333 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9WTN5 CHOYP_LOC100714922.1.1 m.39817 sp TPC1_RAT 27.581 678 412 14 24 669 26 656 2.31E-60 219 TPC1_RAT reviewed Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1) Tpcn1 Tpc1 Rattus norvegicus (Rat) 817 membrane depolarization during action potential [GO:0086010] GO:0005245; GO:0005765; GO:0005886; GO:0010008; GO:0016021; GO:0072345; GO:0086010 0 0 0 PF00520; D3ZVM4 CHOYP_BRAFLDRAFT_77992.1.3 m.35147 sp LIN41_RAT 24.841 157 95 6 23 172 265 405 2.32E-06 53.9 LIN41_RAT reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) Trim71 Lin41 Rattus norvegicus (Rat) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; E6ZHJ8 CHOYP_FXL15.2.3 m.55263 sp FXL15_DICLA 40.541 259 154 0 28 286 12 270 2.32E-62 202 FXL15_DICLA reviewed F-box/LRR-repeat protein 15 fbxl15 DLA_Ib03740 DLA_Ib03750 Dicentrarchus labrax (European seabass) (Morone labrax) 292 bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000086; GO:0005737; GO:0009953; GO:0016567; GO:0019005; GO:0030282; GO:0030513; GO:0031146 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00646;PF13516; O00370 CHOYP_LOC100490320.2.2 m.36450 sp LORF2_HUMAN 32.44 336 221 4 2 333 555 888 2.32E-43 163 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O01393 CHOYP_LOC100533354.3.6 m.44257 sp UNC9_CAEEL 45.062 162 89 0 43 204 20 181 2.32E-46 160 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O43805 CHOYP_BRAFLDRAFT_57176.1.5 m.10287 sp SSNA1_HUMAN 34.507 142 68 2 18 159 3 119 2.32E-15 71.6 SSNA1_HUMAN reviewed Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa) SSNA1 NA14 Homo sapiens (Human) 119 ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; G2/M transition of mitotic cell cycle [GO:0000086]; intraciliary transport [GO:0042073] GO:0000086; GO:0005634; GO:0005813; GO:0005829; GO:0005886; GO:0036064; GO:0042073; GO:0042802; GO:0060830 0 0 0 0 O57592 CHOYP_RL7A.5.6 m.36021 sp RL7A_TAKRU 75.2 125 31 0 31 155 84 208 2.32E-65 203 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O70277 CHOYP_BRAFLDRAFT_205965.38.43 m.64635 sp TRIM3_RAT 25.503 149 107 3 247 392 596 743 2.32E-07 56.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75691 CHOYP_UTP20.4.4 m.27798 sp UTP20_HUMAN 54.701 117 53 0 37 153 909 1025 2.32E-34 129 UTP20_HUMAN reviewed Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) 2785 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of cell proliferation [GO:0008285]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0008285; GO:0030686; GO:0030688; GO:0032040; GO:0044822 0 0 0 PF07539; P10394 CHOYP_LOC100334180.1.1 m.14887 sp POL4_DROME 29.221 308 198 7 12 314 873 1165 2.32E-29 121 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P12276 CHOYP_FASN.1.4 m.2326 sp FAS_CHICK 71.512 172 48 1 2 172 570 741 2.32E-81 265 FAS_CHICK reviewed Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] FASN FAS Gallus gallus (Chicken) 2512 fatty acid biosynthetic process [GO:0006633]; lactate metabolic process [GO:0006089]; positive regulation of appetite [GO:0032100] GO:0003697; GO:0004312; GO:0004313; GO:0004314; GO:0004315; GO:0004316; GO:0004317; GO:0004319; GO:0004320; GO:0005623; GO:0006089; GO:0006633; GO:0016295; GO:0016296; GO:0031177; GO:0032100; GO:0047117; GO:0047451; GO:0102132 0 0 0 PF00698;PF00107;PF16197;PF00109;PF02801;PF08659;PF00550;PF14765;PF00975; P20273 CHOYP_LOC100880815.2.7 m.39528 sp CD22_HUMAN 23.473 622 404 22 24 603 18 609 2.32E-22 106 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P55043 CHOYP_LOC100865163.3.5 m.38890 sp RAD_RAT 42.442 172 81 4 163 324 89 252 2.32E-32 126 RAD_RAT reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) Rrad Rad Rattus norvegicus (Rat) 306 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; P82186 CHOYP_GUN.1.2 m.26883 sp GUN_MYTED 69.231 182 49 3 18 194 1 180 2.32E-89 263 GUN_MYTED reviewed "Endoglucanase (EC 3.2.1.4) (CMCase) (Cellulase) (Endo-1,4-beta-glucanase)" 0 Mytilus edulis (Blue mussel) 181 cellulose catabolic process [GO:0030245] GO:0008810; GO:0030245 0 0 0 0 Q03348 CHOYP_LOC100185528.1.1 m.39084 sp PTPRA_RAT 28.316 671 439 17 515 1154 129 788 2.32E-71 258 PTPRA_RAT reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) 796 oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714] GO:0004725; GO:0005886; GO:0016021; GO:0032403; GO:0043231; GO:0048709; GO:0048714 0 0 0 PF00102; Q11212 CHOYP_ACTA.1.2 m.13068 sp ACT_SPOLI 91.892 111 9 0 1 111 35 145 2.32E-68 213 ACT_SPOLI reviewed Actin (Fragment) 0 Spodoptera littoralis (Egyptian cotton leafworm) 164 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q1LUI2 CHOYP_HDDC2.1.1 m.11210 sp HDDC2_DANRE 55.801 181 78 1 23 203 1 179 2.32E-69 213 HDDC2_DANRE reviewed HD domain-containing protein 2 hddc2 si:ch211-208c9.2 zgc:112330 Danio rerio (Zebrafish) (Brachydanio rerio) 200 0 0 0 0 0 PF13023; Q4FZG9 CHOYP_LOC581594.2.3 m.34837 sp NUA4L_MOUSE 39.13 69 42 0 19 87 11 79 2.32E-12 60.5 NUA4L_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 Ndufa4l2 Mus musculus (Mouse) 87 hydrogen ion transmembrane transport [GO:1902600] GO:0005751; GO:0008137; GO:1902600 0 0 0 PF06522; Q5XJ85 CHOYP_MYD88.3.7 m.24221 sp MYD88_DANRE 41.176 136 73 4 6 137 149 281 2.32E-20 88.6 MYD88_DANRE reviewed Myeloid differentiation primary response protein MyD88 myd88 Danio rerio (Zebrafish) (Brachydanio rerio) 284 activation of innate immune response [GO:0002218]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil chemotaxis [GO:0030593]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; response to molecule of bacterial origin [GO:0002237] GO:0002218; GO:0002237; GO:0002755; GO:0005737; GO:0006954; GO:0030593; GO:0043123; GO:0045087; GO:1901532; GO:1901534 0 0 0 PF00531;PF01582; Q6AZD1 CHOYP_BRAFLDRAFT_260475.2.2 m.56061 sp T179A_DANRE 31.532 222 145 4 8 225 7 225 2.32E-28 110 T179A_DANRE reviewed Transmembrane protein 179 tmem179 si:dkey-85n7.1 zgc:101058 Danio rerio (Zebrafish) (Brachydanio rerio) 232 0 GO:0016021 0 0 0 0 Q6DHQ1 CHOYP_VSOP.1.1 m.25198 sp HVCN1_DANRE 44.149 188 101 1 40 227 52 235 2.32E-50 168 HVCN1_DANRE reviewed Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) hvcn1 zgc:92181 Danio rerio (Zebrafish) (Brachydanio rerio) 235 cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transport [GO:0015992] GO:0005887; GO:0015992; GO:0030171; GO:0071294; GO:0071467 0 0 0 PF00520; Q6DJI9 CHOYP_ZCRB1.1.1 m.40598 sp ZCRB1_XENLA 62.332 223 74 3 1 218 1 218 2.32E-85 254 ZCRB1_XENLA reviewed Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) zcrb1 Xenopus laevis (African clawed frog) 218 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005681; GO:0006397; GO:0008270; GO:0008380 0 0 0 PF00076;PF00098; Q6DRG1 CHOYP_LOC101168891.1.1 m.30839 sp RBM42_DANRE 52.321 237 98 4 215 438 168 402 2.32E-70 231 RBM42_DANRE reviewed RNA-binding protein 42 (RNA-binding motif protein 42) rbm42 Danio rerio (Zebrafish) (Brachydanio rerio) 402 lens development in camera-type eye [GO:0002088] GO:0000166; GO:0002088; GO:0003723; GO:0005634; GO:0005737 0 0 0 PF00076; Q6GLP4 CHOYP_LOC100124228.1.1 m.60788 sp RMD5A_XENLA 56.633 392 168 2 161 551 1 391 2.32E-165 478 RMD5A_XENLA reviewed Protein RMD5 homolog A rmnd5a Xenopus laevis (African clawed frog) 391 0 0 0 0 0 PF10607; Q6PFY8 CHOYP_TRI45.17.23 m.43262 sp TRI45_MOUSE 29.557 203 122 6 15 205 135 328 2.32E-12 68.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7ZWF4 CHOYP_LOC100900639.1.1 m.55430 sp RN145_DANRE 22.709 251 179 5 197 443 234 473 2.32E-08 60.1 RN145_DANRE reviewed RING finger protein 145 rnf145 zgc:56435 Danio rerio (Zebrafish) (Brachydanio rerio) 685 hemopoiesis [GO:0030097]; myeloid cell development [GO:0061515]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0008270; GO:0016021; GO:0030097; GO:0042787; GO:0043161; GO:0061515; GO:0061630 0 0 0 PF13705;PF13639; Q80TY5 CHOYP_LOC100735249.2.2 m.47735 sp VP13B_MOUSE 26.364 550 336 18 3 505 813 1340 2.32E-35 145 VP13B_MOUSE reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) 4013 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q8C525 CHOYP_NEMVEDRAFT_V1G199927.8.9 m.53791 sp M21D2_MOUSE 25 160 112 3 167 325 170 322 2.32E-07 57.4 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8C6L5 CHOYP_NEMVEDRAFT_V1G218264.11.14 m.51529 sp CGAS_MOUSE 22.823 333 211 12 26 334 170 480 2.32E-09 63.2 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8HXX6 CHOYP_LOC100699750.1.2 m.4691 sp SAP3_MACFA 29.677 155 92 4 1 146 5 151 2.32E-16 77.8 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8K0U4 CHOYP_HS12A.22.33 m.58621 sp HS12A_MOUSE 34.8 250 146 6 1 239 416 659 2.32E-34 134 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8R4F0 CHOYP_LOC100878904.1.1 m.26051 sp MCLN3_MOUSE 41.712 549 290 7 83 630 34 553 2.32E-149 446 MCLN3_MOUSE reviewed Mucolipin-3 Mcoln3 Mus musculus (Mouse) 553 auditory receptor cell differentiation [GO:0042491]; ion transport [GO:0006811]; locomotory behavior [GO:0007626] GO:0005737; GO:0005886; GO:0006811; GO:0007626; GO:0016021; GO:0042491 0 0 0 PF08016; Q9BQB6 CHOYP_DANA_GF24303.1.1 m.33642 sp VKOR1_HUMAN 54.762 84 38 0 12 95 11 94 2.32E-26 98.6 VKOR1_HUMAN reviewed "Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)" VKORC1 VKOR MSTP134 MSTP576 UNQ308/PRO351 Homo sapiens (Human) 163 blood coagulation [GO:0007596]; bone development [GO:0060348]; drug metabolic process [GO:0017144]; peptidyl-glutamic acid carboxylation [GO:0017187]; vitamin K metabolic process [GO:0042373] GO:0005789; GO:0007596; GO:0016021; GO:0017144; GO:0017187; GO:0042373; GO:0047057; GO:0048038; GO:0060348 0 0 0 PF07884; Q9H2H8 CHOYP_LOC100929997.1.1 m.23658 sp PPIL3_HUMAN 82.292 96 17 0 10 105 1 96 2.32E-58 180 PPIL3_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase-like 3 (PPIase) (EC 5.2.1.8) (Cyclophilin J) (CyPJ) (Cyclophilin-like protein PPIL3) (Rotamase PPIL3) PPIL3 Homo sapiens (Human) 161 "mRNA splicing, via spliceosome [GO:0000398]; protein folding [GO:0006457]" GO:0000398; GO:0003755; GO:0006457; GO:0071013 0 0 0 PF00160; Q9I6M5 CHOYP_LOC661308.1.1 m.63939 sp DAVD_PSEAE 44.792 96 53 0 40 135 2 97 2.32E-23 98.2 DAVD_PSEAE reviewed Glutarate-semialdehyde dehydrogenase DavD (EC 1.2.1.20) davD PA0265 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 483 gamma-aminobutyric acid catabolic process [GO:0009450]; L-lysine catabolic process [GO:0019477] GO:0004029; GO:0004777; GO:0009013; GO:0009450; GO:0019477; GO:0047949 0 0 0 PF00171; Q9LQV2 CHOYP_BRAFLDRAFT_99723.3.9 m.36431 sp RDR1_ARATH 38.748 751 411 16 82 805 369 1097 2.32E-139 456 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; Q9QZU4 CHOYP_BRAFLDRAFT_119296.10.16 m.46615 sp HRSL1_MOUSE 34.091 132 79 4 36 165 18 143 2.32E-18 81.6 HRSL1_MOUSE reviewed Phospholipid-metabolizing enzyme A-C1 (EC 2.3.1.-) (EC 3.1.1.-) (HRAS-like suppressor 1) (HRSL1) Hrasls Hrasrs Mus musculus (Mouse) 167 ether lipid metabolic process [GO:0046485]; lipid catabolic process [GO:0016042]; peroxisome organization [GO:0007031]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558] GO:0001558; GO:0004620; GO:0005641; GO:0005737; GO:0005777; GO:0007031; GO:0007265; GO:0016021; GO:0016042; GO:0016740; GO:0046485 0 0 0 PF04970; Q9UIF3 CHOYP_BRAFLDRAFT_123537.2.2 m.50531 sp TEKT2_HUMAN 59.42 414 152 2 1 413 1 399 2.32E-167 479 TEKT2_HUMAN reviewed Tektin-2 (Tektin-t) (Testicular tektin) (Testicular tektin B1-like protein) (TEKTB1) (Tektin-B1) TEKT2 Homo sapiens (Human) 430 inner dynein arm assembly [GO:0036159]; sperm motility [GO:0030317] GO:0005634; GO:0005737; GO:0005874; GO:0030317; GO:0031514; GO:0036159 0 0 0 0 A4IHD9 CHOYP_MED25.2.2 m.42845 sp MED25_XENTR 48.826 213 106 3 20 231 13 223 2.33E-65 235 MED25_XENTR reviewed Mediator of RNA polymerase II transcription subunit 25 (Mediator complex subunit 25) med25 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 805 "palate development [GO:0060021]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0060021 0 0 0 PF11232;PF11244;PF11235;PF11265; D2GXS7 CHOYP_LOC100374342.10.19 m.33807 sp TRIM2_AILME 22.727 220 148 6 143 355 490 694 2.33E-09 62.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D8VNS7 CHOYP_BRAFLDRAFT_125263.4.9 m.52342 sp FCNV1_CERRY 45.283 212 111 3 76 285 129 337 2.33E-56 187 FCNV1_CERRY reviewed Ryncolin-1 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; O00461 CHOYP_GOLI4.2.4 m.15493 sp GOLI4_HUMAN 25.606 289 179 5 3 256 4 291 2.33E-13 75.9 GOLI4_HUMAN reviewed "Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)" GOLIM4 GIMPC GOLPH4 GPP130 Homo sapiens (Human) 696 transport [GO:0006810] GO:0000139; GO:0005654; GO:0005794; GO:0005796; GO:0005801; GO:0006810; GO:0010008; GO:0016020; GO:0016021; GO:0030133; GO:0030139; GO:0032580 0 0 0 0 O15990 CHOYP_KARG.8.11 m.45498 sp KARG_LIOJA 68.208 173 54 1 1 173 167 338 2.33E-81 249 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O75581 CHOYP_LOC578656.6.15 m.33898 sp LRP6_HUMAN 24.176 728 476 23 36 727 96 783 2.33E-55 209 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; O95236 CHOYP_contig_041802 m.47909 sp APOL3_HUMAN 23.967 242 169 4 21 250 148 386 2.33E-11 66.6 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P10079 CHOYP_LOC100634060.29.37 m.63953 sp FBP1_STRPU 53.333 210 98 0 1 210 271 480 2.33E-66 230 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_LOC100640260.2.2 m.38067 sp FBP1_STRPU 51.22 492 240 0 266 757 214 705 2.33E-152 493 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P16157 CHOYP_LOC100639010.1.9 m.5039 sp ANK1_HUMAN 37.799 209 130 0 341 549 352 560 2.33E-32 136 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20273 CHOYP_CEACAM5.2.5 m.14585 sp CD22_HUMAN 30.769 195 122 9 224 410 234 423 2.33E-13 75.9 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P30599 CHOYP_DPSE_GA15416.1.2 m.56229 sp CHS2_USTMA 27.411 394 224 16 692 1025 542 933 2.33E-19 98.6 CHS2_USTMA reviewed Chitin synthase 2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 2) CHS2 UMAG_04290 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 1074 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0030659; GO:0071555 0 0 0 PF01644;PF08407;PF13632; P34743 CHOYP_TSN18.1.1 m.14982 sp BTG1_CHICK 44.211 95 49 2 1 91 76 170 2.33E-17 76.3 BTG1_CHICK reviewed Protein BTG1 (B-cell translocation gene 1 protein) BTG1 Gallus gallus (Chicken) 170 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663] GO:0005634; GO:0005737; GO:0008285; GO:0019899; GO:0045603; GO:0045663; GO:0045766; GO:2000271 0 0 0 PF07742; P48728 CHOYP_GCST.1.1 m.16047 sp GCST_HUMAN 59.896 384 150 3 22 404 23 403 2.33E-165 472 GCST_HUMAN reviewed "Aminomethyltransferase, mitochondrial (EC 2.1.2.10) (Glycine cleavage system T protein) (GCVT)" AMT GCST Homo sapiens (Human) 403 glycine catabolic process [GO:0006546]; glycine decarboxylation via glycine cleavage system [GO:0019464]; glyoxylate metabolic process [GO:0046487] GO:0004047; GO:0005739; GO:0005759; GO:0006546; GO:0008483; GO:0019464; GO:0046487 0 0 0 PF01571;PF08669; P61210 CHOYP_LOC100637317.1.4 m.21967 sp ARF1_LOCMI 58.791 182 71 2 1 182 1 178 2.33E-75 227 ARF1_LOCMI reviewed ADP-ribosylation factor 1 (lARF1) ARF1 Locusta migratoria (Migratory locust) 182 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; P62916 CHOYP_TF2B.1.1 m.40027 sp TF2B_RAT 75.079 317 76 2 1 317 1 314 2.33E-178 498 TF2B_RAT reviewed Transcription initiation factor IIB (General transcription factor TFIIB) (RNA polymerase II alpha initiation factor) Gtf2b Rattus norvegicus (Rat) 316 "DNA-templated transcription, initiation [GO:0006352]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006352; GO:0006355; GO:0008270 0 0 0 PF08271;PF00382; P70490 CHOYP_CRE-DIG-1.1.1 m.26794 sp MFGM_RAT 32.941 340 186 13 423 743 111 427 2.33E-41 164 MFGM_RAT reviewed Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (O-acetyl GD3 ganglioside synthase) (AGS) (SED1) Mfge8 Ags Rattus norvegicus (Rat) 427 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of cell proliferation [GO:0008284]; response to estrogen [GO:0043627]; single fertilization [GO:0007338] GO:0001525; GO:0005576; GO:0007155; GO:0007338; GO:0008284; GO:0016020; GO:0043627 0 0 0 PF00008;PF00754; Q04832 CHOYP_TTHERM_01091290.1.1 m.33533 sp HEXP_LEIMA 37.903 124 52 5 114 224 45 156 2.33E-17 83.2 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q0D289 CHOYP_LOC100865563.1.1 m.30981 sp CP052_DANRE 44.762 105 50 4 20 121 1 100 2.33E-20 84 CP052_DANRE reviewed Uncharacterized protein C16orf52 homolog zgc:153595 Danio rerio (Zebrafish) (Brachydanio rerio) 167 0 0 0 0 0 0 Q15063 CHOYP_BRAFLDRAFT_127065.1.7 m.4586 sp POSTN_HUMAN 30.034 293 180 8 5 290 92 366 2.33E-25 109 POSTN_HUMAN reviewed Periostin (PN) (Osteoblast-specific factor 2) (OSF-2) POSTN OSF2 Homo sapiens (Human) 836 bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-C motif) ligand 2 secretion [GO:1904209]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; skeletal system development [GO:0001501] GO:0001501; GO:0001666; GO:0001953; GO:0003073; GO:0005578; GO:0005615; GO:0005802; GO:0007155; GO:0008201; GO:0008593; GO:0009612; GO:0014850; GO:0014911; GO:0030198; GO:0031012; GO:0031594; GO:0032355; GO:0044344; GO:0046872; GO:0050839; GO:0071307; GO:0071356; GO:0071560; GO:1900025; GO:1904209; GO:1990138; GO:1990523 0 0 0 PF02469; Q17RM4 CHOYP_BRAFLDRAFT_89287.4.4 m.20760 sp CC142_HUMAN 33.835 266 152 7 78 337 417 664 2.33E-30 125 CC142_HUMAN reviewed Coiled-coil domain-containing protein 142 CCDC142 PSEC0243 Homo sapiens (Human) 750 0 0 0 0 0 0 Q54HH2 CHOYP_ACID_2317.1.1 m.25178 sp SRR_DICDI 36.615 325 193 6 11 326 3 323 2.33E-53 181 SRR_DICDI reviewed Probable serine racemase (EC 4.3.1.17) (EC 4.3.1.18) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (L-serine ammonia-lyase) (L-serine dehydratase) srr DDB_G0289463 Dictyostelium discoideum (Slime mold) 324 D-serine biosynthetic process [GO:0070179]; L-serine metabolic process [GO:0006563]; protein dehydration [GO:0018249] GO:0000287; GO:0003941; GO:0005524; GO:0005737; GO:0006563; GO:0008721; GO:0018249; GO:0030170; GO:0030378; GO:0070179 0 0 0 PF00291; Q54M77 CHOYP_LOC100370896.4.4 m.56380 sp ROCO8_DICDI 31.953 169 107 5 829 992 1689 1854 2.33E-20 101 ROCO8_DICDI reviewed Probable serine/threonine-protein kinase roco8 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 8) roco8 DDB_G0286127 Dictyostelium discoideum (Slime mold) 1867 small GTPase mediated signal transduction [GO:0007264] GO:0004674; GO:0005524; GO:0005525; GO:0005622; GO:0007264 0 0 0 PF16095;PF00610;PF13855;PF07714;PF08477; Q5HZP1 CHOYP_LOC100373317.1.1 m.16740 sp RNH2B_XENLA 41.497 294 165 6 28 315 12 304 2.33E-73 231 RNH2B_XENLA reviewed Ribonuclease H2 subunit B (RNase H2 subunit B) (Ribonuclease HI subunit B) rnaseh2b Xenopus laevis (African clawed frog) 306 RNA catabolic process [GO:0006401] GO:0005634; GO:0006401; GO:0032299 0 0 cd09270; PF09468; Q5XIK8 CHOYP_CCNB.2.2 m.16936 sp CTSL2_RAT 56.583 357 131 7 138 489 127 464 2.33E-129 386 CTSL2_RAT reviewed CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-) Ctdspl2 Rattus norvegicus (Rat) 465 0 GO:0004721 0 0 0 PF03031; Q6DN14 CHOYP_PHUM_PHUM335410.1.1 m.33405 sp MCTP1_HUMAN 26.163 344 216 12 465 791 265 587 2.33E-17 91.7 MCTP1_HUMAN reviewed Multiple C2 and transmembrane domain-containing protein 1 MCTP1 Homo sapiens (Human) 999 calcium-mediated signaling [GO:0019722] GO:0005509; GO:0005783; GO:0016021; GO:0019722 0 0 0 PF00168;PF08372; Q6NZK5 CHOYP_K1328.1.1 m.13528 sp K1328_MOUSE 37.566 189 98 6 26 213 13 182 2.33E-21 102 K1328_MOUSE reviewed Protein hinderin Kiaa1328 Mus musculus (Mouse) 612 0 0 0 0 0 PF15369; Q6P2X9 CHOYP_LOC100907430.1.1 m.59277 sp MOT12_XENTR 29.801 151 90 5 6 155 111 246 2.33E-08 59.3 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6RKD8 CHOYP_LOC101073980.1.1 m.31894 sp FLRT1_MOUSE 22.457 521 280 14 16 463 38 507 2.33E-20 97.8 FLRT1_MOUSE reviewed Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin leucine rich transmembrane protein 1) Flrt1 Mus musculus (Mouse) 674 cell adhesion [GO:0007155]; cytokine-mediated signaling pathway [GO:0019221]; dendrite development [GO:0016358]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965] GO:0004860; GO:0005104; GO:0005615; GO:0005789; GO:0005887; GO:0005911; GO:0005925; GO:0006469; GO:0007155; GO:0008543; GO:0016358; GO:0019221; GO:0030659; GO:0031410; GO:0032809; GO:0044306; GO:0046426; GO:0048471; GO:0051965; GO:1990138 0 0 0 PF13855;PF01462; Q6WYY1 CHOYP_PCDH9.2.5 m.34196 sp PC11X_PANPA 31.818 836 528 16 22 828 28 850 2.33E-114 387 PC11X_PANPA reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) PCDH11X PCDH11 PCDHX Pan paniscus (Pygmy chimpanzee) (Bonobo) 1347 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q6ZRF8 CHOYP_LOC100369014.7.9 m.47310 sp RN207_HUMAN 22.176 239 169 8 28 262 73 298 2.33E-08 60.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7T392 CHOYP_LOC100187278.2.2 m.60442 sp T179B_DANRE 24 200 137 6 19 216 18 204 2.33E-11 64.3 T179B_DANRE reviewed Transmembrane protein 179B tmem179b zgc:110591 Danio rerio (Zebrafish) (Brachydanio rerio) 219 0 GO:0016021 0 0 0 0 Q862Z3 CHOYP_NEMVEDRAFT_V1G214844.18.34 m.40421 sp UROM_CANLF 36.29 124 70 4 21 142 173 289 2.33E-12 72.4 UROM_CANLF reviewed "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" UMOD Canis lupus familiaris (Dog) (Canis familiaris) 642 0 GO:0000922; GO:0005509; GO:0005576; GO:0016323; GO:0016324; GO:0031225; GO:0060170; GO:0072372 0 0 0 PF07645;PF00100; Q86VQ0 CHOYP_LOC100372739.1.1 m.55428 sp LCA5_HUMAN 39.556 225 133 1 60 281 77 301 2.33E-36 150 LCA5_HUMAN reviewed Lebercilin (Leber congenital amaurosis 5 protein) LCA5 C6orf152 Homo sapiens (Human) 697 protein transport [GO:0015031] GO:0005737; GO:0005815; GO:0005929; GO:0015031; GO:0032403 0 0 0 PF15619; Q8BK67 CHOYP_BRAFLDRAFT_67459.2.2 m.56116 sp RCC2_MOUSE 57.176 425 180 1 52 474 93 517 2.33E-177 510 RCC2_MOUSE reviewed Protein RCC2 Rcc2 Kiaa1470 Mus musculus (Mouse) 520 activation of GTPase activity [GO:0090630]; cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; mitotic nuclear division [GO:0007067]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027] GO:0005634; GO:0005730; GO:0005874; GO:0005886; GO:0007067; GO:0007229; GO:0008017; GO:0010762; GO:0010971; GO:0019901; GO:0019904; GO:0030334; GO:0030496; GO:0031267; GO:0031901; GO:0034260; GO:0034506; GO:0044822; GO:0045184; GO:0048041; GO:0048365; GO:0051301; GO:0051895; GO:0051987; GO:0072356; GO:0090630; GO:1900025; GO:1900027; GO:1990023 0 0 0 PF00415; Q8INF0 CHOYP_BRAFLDRAFT_268816.1.1 m.17305 sp GCY8E_DROME 55.446 101 45 0 1 101 1 101 2.33E-33 124 GCY8E_DROME reviewed Soluble guanylate cyclase 88E (EC 4.6.1.2) Gyc88E CG4154 Drosophila melanogaster (Fruit fly) 947 cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; response to hypoxia [GO:0001666]; response to reactive oxygen species [GO:0000302]; signal transduction [GO:0007165] GO:0000302; GO:0001666; GO:0004383; GO:0005525; GO:0005886; GO:0006182; GO:0007165; GO:0008074; GO:0019825; GO:0019826; GO:0020037; GO:0035556; GO:0042803; GO:0046872; GO:0046982; GO:0070025; GO:0070026 0 0 0 PF00211;PF07700;PF07701; Q8K3K9 CHOYP_LOC100707408.1.1 m.5285 sp GIMA4_RAT 35.981 214 131 3 27 238 27 236 2.33E-39 143 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8VCQ3 CHOYP_NRBF2.1.1 m.43388 sp NRBF2_MOUSE 46.25 80 43 0 14 93 1 80 2.33E-15 77.8 NRBF2_MOUSE reviewed Nuclear receptor-binding factor 2 (NRBF-2) Nrbf2 Mus musculus (Mouse) 287 "autophagy [GO:0006914]; regulation of autophagy [GO:0010506]; regulation of lipid kinase activity [GO:0043550]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005667; GO:0005737; GO:0005776; GO:0006351; GO:0006357; GO:0006914; GO:0010506; GO:0016922; GO:0031410; GO:0034976; GO:0035032; GO:0043550 0 0 0 PF08961;PF17169; Q8VEM8 CHOYP_KIF2A.2.2 m.62688 sp MPCP_MOUSE 70.391 358 90 2 1 347 1 353 2.33E-177 499 MPCP_MOUSE reviewed "Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3)" Slc25a3 Mus musculus (Mouse) 357 translation [GO:0006412] GO:0003735; GO:0005634; GO:0005730; GO:0005739; GO:0005743; GO:0006412; GO:0015293; GO:0016020; GO:0016021; GO:0032403; GO:0043209; GO:0070062 0 0 0 PF00153; Q91X17 CHOYP_NEMVEDRAFT_V1G214844.2.34 m.2882 sp UROM_MOUSE 36.885 122 70 3 22 142 173 288 2.33E-16 79 UROM_MOUSE reviewed "Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form]" Umod Mus musculus (Mouse) 642 chemical homeostasis [GO:0048878]; excretion [GO:0007588]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; leukocyte cell-cell adhesion [GO:0007159]; metanephric ascending thin limb development [GO:0072218]; metanephric distal convoluted tubule development [GO:0072221]; metanephric thick ascending limb development [GO:0072233]; neutrophil migration [GO:1990266]; regulation of ion homeostasis [GO:2000021]; response to organic substance [GO:0010033] GO:0000922; GO:0005509; GO:0005615; GO:0005794; GO:0007157; GO:0007159; GO:0007588; GO:0010033; GO:0016323; GO:0016324; GO:0019864; GO:0031225; GO:0031410; GO:0045121; GO:0048878; GO:0060170; GO:0070062; GO:0072218; GO:0072221; GO:0072233; GO:0072372; GO:1990266; GO:2000021 0 0 0 PF12947;PF07645;PF00100; Q96CS7 CHOYP_LOC100545221.1.1 m.35076 sp PKHB2_HUMAN 35.47 234 117 8 4 217 1 220 2.33E-35 127 PKHB2_HUMAN reviewed Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2) PLEKHB2 EVT2 Homo sapiens (Human) 222 regulation of cell differentiation [GO:0045595] GO:0016021; GO:0045595; GO:0055038 0 0 0 PF00169; Q96IP4 CHOYP_LOC100369378.1.1 m.5392 sp FA46A_HUMAN 64.865 333 112 4 9 341 65 392 2.33E-149 433 FA46A_HUMAN reviewed Protein FAM46A (HBV X-transactivated gene 11 protein) (HBV XAg-transactivated protein 11) FAM46A C6orf37 XTP11 Homo sapiens (Human) 442 regulation of blood coagulation [GO:0030193]; regulation of gene expression [GO:0010468] GO:0010468; GO:0030193; GO:0044822 0 0 0 PF07984; Q96IP4 CHOYP_LOC100378790.1.1 m.43744 sp FA46A_HUMAN 64.865 333 112 4 9 341 65 392 2.33E-149 433 FA46A_HUMAN reviewed Protein FAM46A (HBV X-transactivated gene 11 protein) (HBV XAg-transactivated protein 11) FAM46A C6orf37 XTP11 Homo sapiens (Human) 442 regulation of blood coagulation [GO:0030193]; regulation of gene expression [GO:0010468] GO:0010468; GO:0030193; GO:0044822 0 0 0 PF07984; Q99719 CHOYP_SEPT5.1.2 m.11458 sp SEPT5_HUMAN 61.69 355 132 3 288 640 15 367 2.33E-160 468 SEPT5_HUMAN reviewed Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1) SEPT5 PNUTL1 Homo sapiens (Human) 369 cytokinesis [GO:0000910]; positive regulation of exocytosis [GO:0045921]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle targeting [GO:0016080] GO:0000910; GO:0003924; GO:0005198; GO:0005525; GO:0005856; GO:0005886; GO:0005938; GO:0008021; GO:0016080; GO:0017157; GO:0043195; GO:0045921; GO:2000300 0 0 cd01850; PF00735; Q99M80 CHOYP_PTPRT.37.45 m.57666 sp PTPRT_MOUSE 33.153 555 339 12 690 1218 882 1430 2.33E-70 262 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BXX0 CHOYP_EMIL2.1.1 m.22528 sp EMIL2_HUMAN 31.847 157 83 6 76 212 895 1047 2.33E-11 65.9 EMIL2_HUMAN reviewed EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) 1053 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030023; GO:0031012 0 0 0 PF00386;PF07546; Q9C0C7 CHOYP_BRAFLDRAFT_126632.1.1 m.11295 sp AMRA1_HUMAN 47.845 232 119 2 715 944 807 1038 2.33E-65 244 AMRA1_HUMAN reviewed Activating molecule in BECN1-regulated autophagy protein 1 AMBRA1 KIAA1736 Homo sapiens (Human) 1298 cell differentiation [GO:0030154]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of cell proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; neural tube development [GO:0021915]; parkin-mediated mitophagy in response to mitochondrial depolarization [GO:0061734]; positive regulation of mitophagy [GO:1903599]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of autophagosome assembly [GO:2000785] GO:0005737; GO:0005739; GO:0005741; GO:0005776; GO:0005829; GO:0005930; GO:0008285; GO:0016236; GO:0021915; GO:0030154; GO:0031625; GO:0043524; GO:0043552; GO:0045335; GO:0048471; GO:0061734; GO:0098779; GO:1903599; GO:2000785 0 0 0 0 Q9JJW6 CHOYP_LOC100375551.1.2 m.27489 sp ALRF2_MOUSE 45.29 276 90 5 1 274 1 217 2.33E-58 188 ALRF2_MOUSE reviewed Aly/REF export factor 2 (Alyref) (RNA and export factor-binding protein 2) Alyref2 Ref2 Refbp2 Mus musculus (Mouse) 218 mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; RNA splicing [GO:0008380] GO:0000166; GO:0003697; GO:0003723; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0051028 0 0 0 PF13865;PF00076; Q9NRA2 CHOYP_LOC100378615.2.2 m.53420 sp S17A5_HUMAN 41.797 512 258 10 1 501 8 490 2.33E-130 391 S17A5_HUMAN reviewed Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) 495 amino acid transport [GO:0006865]; anion transport [GO:0006820]; ion transport [GO:0006811]; sialic acid transport [GO:0015739] GO:0005351; GO:0005737; GO:0005765; GO:0005886; GO:0005887; GO:0006811; GO:0006820; GO:0006865; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0030054; GO:0030672 0 0 cd06174; PF07690; Q9VXX8 CHOYP_LOC100533258.1.6 m.4422 sp RL371_DROME 72.826 92 25 0 1 92 1 92 2.33E-44 141 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9VXX8 CHOYP_LOC100533258.3.6 m.13715 sp RL371_DROME 72.826 92 25 0 1 92 1 92 2.33E-44 141 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9VXX8 CHOYP_LOC100533258.6.6 m.48144 sp RL371_DROME 72.826 92 25 0 1 92 1 92 2.33E-44 141 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9Y5X5 CHOYP_LOC100378936.1.1 m.175 sp NPFF2_HUMAN 34.066 364 209 7 64 407 151 503 2.33E-53 189 NPFF2_HUMAN reviewed Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) 522 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; detection of abiotic stimulus [GO:0009582]; G-protein coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase activity [GO:0045761]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of MAPK cascade [GO:0043408]; response to peptide [GO:1901652] GO:0004930; GO:0005886; GO:0005887; GO:0007186; GO:0007268; GO:0008188; GO:0009582; GO:0015629; GO:0032870; GO:0042277; GO:0043408; GO:0045761; GO:1901652; GO:2000479 0 0 0 PF00001; Q9Z0Z5 CHOYP_S13A3.1.1 m.18310 sp S13A3_RAT 43.62 337 173 4 25 350 270 600 2.33E-85 272 S13A3_RAT reviewed Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (rNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) Slc13a3 Nadc3 Sdct2 Rattus norvegicus (Rat) 600 aspartate transport [GO:0015810]; citrate transport [GO:0015746]; dicarboxylic acid transport [GO:0006835]; succinate transport [GO:0015744] GO:0005310; GO:0005343; GO:0005887; GO:0006835; GO:0015137; GO:0015141; GO:0015183; GO:0015744; GO:0015746; GO:0015810; GO:0016020; GO:0016021; GO:0017153 0 0 0 PF00939; Q9Z2P6 CHOYP_LOC100907408.1.1 m.24444 sp SNP29_RAT 31.579 228 146 4 15 235 33 257 2.33E-27 108 SNP29_RAT reviewed Synaptosomal-associated protein 29 (SNAP-29) (Golgi SNARE of 32 kDa) (Gs32) (Soluble 29 kDa NSF attachment protein) (Vesicle-membrane fusion protein SNAP-29) Snap29 Rattus norvegicus (Rat) 257 autophagosome maturation [GO:0097352]; cilium assembly [GO:0042384]; protein transport [GO:0015031]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082] GO:0000139; GO:0000421; GO:0005484; GO:0005886; GO:0015031; GO:0016082; GO:0019905; GO:0020018; GO:0031201; GO:0031410; GO:0031629; GO:0042384; GO:0043195; GO:0097352 0 0 0 0 A4Q9F4 CHOYP_BRAFLDRAFT_86836.2.2 m.62709 sp TTL11_MOUSE 37.54 618 319 11 17 624 122 682 2.34E-135 416 TTL11_MOUSE reviewed Tubulin polyglutamylase TTLL11 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 11) Ttll11 Mus musculus (Mouse) 727 microtubule severing [GO:0051013]; protein polyglutamylation [GO:0018095] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0016874; GO:0018095; GO:0051013 0 0 0 PF03133; A8MXE2 CHOYP_DPSE_GA18536.1.2 m.35569 sp YI036_HUMAN 31.25 224 147 3 78 299 70 288 2.34E-27 113 YI036_HUMAN reviewed "Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC100288842 (EC 2.4.1.-) (Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC402377) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 pseudogene)" 0 Homo sapiens (Human) 369 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 0 0 0 PF01762; O00370 CHOYP_LOC100368926.5.5 m.55016 sp LORF2_HUMAN 27.136 199 137 5 6 199 693 888 2.34E-14 79.3 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O43301 CHOYP_LOC100223480.1.4 m.3123 sp HS12A_HUMAN 31.429 140 92 2 2 138 511 649 2.34E-17 80.5 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75581 CHOYP_LOC578599.1.8 m.12749 sp LRP6_HUMAN 24.971 873 587 23 117 968 100 925 2.34E-65 248 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; P08548 CHOYP_LOC100892567.4.8 m.32403 sp LIN1_NYCCO 28.718 195 123 6 24 210 441 627 2.34E-14 74.7 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P16157 CHOYP_LOC763941.4.4 m.64213 sp ANK1_HUMAN 38.202 267 165 0 33 299 248 514 2.34E-41 155 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P30151 CHOYP_EF1B.2.7 m.30853 sp EF1B_XENLA 64.8 125 37 2 14 131 66 190 2.34E-47 155 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P34147 CHOYP_LOC100367936.1.2 m.15564 sp RACA_DICDI 30.57 579 343 14 4 539 3 565 2.34E-67 232 RACA_DICDI reviewed Rho-related protein racA racA DDB_G0286555 Dictyostelium discoideum (Slime mold) 598 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0019901 0 0 0 PF00651;PF00071; P46088 CHOYP_LOC100374909.2.2 m.57748 sp GST_NOTSL 37.198 207 126 2 1 207 1 203 2.34E-39 137 GST_NOTSL reviewed Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma) 0 Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei) 203 0 GO:0004364; GO:0005737 0 0 0 PF14497;PF02798; P70031 CHOYP_CCKAR.4.6 m.43964 sp CCKAR_XENLA 40.153 391 210 6 34 405 65 450 2.34E-88 278 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; P98081 CHOYP_DAB2.1.1 m.22396 sp DAB_DROME 60.69 145 57 0 38 182 38 182 2.34E-52 202 DAB_DROME reviewed Protein disabled Dab CG9695 Drosophila melanogaster (Fruit fly) 2224 cellularization [GO:0007349]; clathrin-mediated endocytosis [GO:0072583]; compound eye photoreceptor development [GO:0042051]; dorsal closure [GO:0007391]; motor neuron axon guidance [GO:0008045]; neurogenesis [GO:0022008]; sevenless signaling pathway [GO:0045500]; synaptic vesicle endocytosis [GO:0048488] GO:0005118; GO:0005737; GO:0007349; GO:0007391; GO:0008045; GO:0017124; GO:0022008; GO:0030424; GO:0042051; GO:0042169; GO:0045202; GO:0045500; GO:0048488; GO:0072583 0 0 0 PF00640; Q29NV5 CHOYP_RM10.2.2 m.57337 sp RM10_DROPS 30.851 188 120 4 56 242 52 230 2.34E-24 100 RM10_DROPS reviewed "39S ribosomal protein L10, mitochondrial (L10mt) (MRP-L10)" mRpL10 GA11028 Drosophila pseudoobscura pseudoobscura (Fruit fly) 253 ribosome biogenesis [GO:0042254]; translation [GO:0006412] GO:0003735; GO:0005762; GO:0006412; GO:0030529; GO:0042254 0 0 0 PF00466; Q3BCR8 CHOYP_TPMT.1.1 m.23120 sp TPMT_PANTR 33.906 233 144 6 27 249 11 243 2.34E-35 129 TPMT_PANTR reviewed Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) TPMT Pan troglodytes (Chimpanzee) 245 nucleobase-containing compound metabolic process [GO:0006139] GO:0005737; GO:0006139; GO:0008119; GO:0070062 0 0 0 PF05724; Q3SX23 CHOYP_BRAFLDRAFT_67608.2.2 m.38354 sp LONP2_BOVIN 65.493 142 46 1 1 139 700 841 2.34E-56 191 LONP2_BOVIN reviewed "Lon protease homolog 2, peroxisomal (EC 3.4.21.-) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease)" LONP2 Bos taurus (Bovine) 852 misfolded or incompletely synthesized protein catabolic process [GO:0006515]; protein import into peroxisome matrix [GO:0016558]; protein processing [GO:0016485]; protein targeting to peroxisome [GO:0006625]; regulation of fatty acid beta-oxidation [GO:0031998] GO:0004176; GO:0004252; GO:0005524; GO:0005634; GO:0005782; GO:0006515; GO:0006625; GO:0016020; GO:0016485; GO:0016558; GO:0031998 0 0 0 PF00004;PF05362;PF02190; Q5E9N9 CHOYP_BRAFLDRAFT_124956.1.1 m.17700 sp APEX2_BOVIN 41.835 545 257 10 1 521 2 510 2.34E-145 430 APEX2_BOVIN reviewed DNA-(apurinic or apyrimidinic site) lyase 2 (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2) APEX2 Bos taurus (Bovine) 514 base-excision repair [GO:0006284]; cell cycle [GO:0007049]; DNA recombination [GO:0006310] GO:0003677; GO:0003906; GO:0005634; GO:0005739; GO:0006284; GO:0006310; GO:0007049; GO:0008270; GO:0008311 0 0 0 PF03372;PF06839; Q5ND28 CHOYP_CED1.16.29 m.40236 sp SREC_MOUSE 33.143 175 96 8 185 347 176 341 2.34E-14 79 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5R7L8 CHOYP_LOC100370656.3.3 m.53244 sp BL1S1_PONAB 65.517 116 40 0 1 116 29 144 2.34E-53 167 BL1S1_PONAB reviewed Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) BLOC1S1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 153 aerobic respiration [GO:0009060]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; lysosome localization [GO:0032418]; neuron projection development [GO:0031175]; peptidyl-lysine acetylation [GO:0018394] GO:0005758; GO:0005759; GO:0005769; GO:0005829; GO:0008089; GO:0009060; GO:0018394; GO:0031083; GO:0031175; GO:0032418; GO:0043234; GO:0048490; GO:1904115 0 0 0 PF06320; Q62925 CHOYP_M3K1.1.1 m.7202 sp M3K1_RAT 44.444 468 238 9 131 578 278 743 2.34E-120 391 M3K1_RAT reviewed Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Map3k1 Mekk Mekk1 Rattus norvegicus (Rat) 1493 activation of JNKK activity [GO:0007256]; activation of MAPKK activity [GO:0000186]; MAPK cascade [GO:0000165]; negative regulation of actin filament bundle assembly [GO:0032232]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to osmotic stress [GO:0006970] GO:0000165; GO:0000186; GO:0000209; GO:0004706; GO:0004709; GO:0004842; GO:0005524; GO:0005737; GO:0006468; GO:0006970; GO:0007256; GO:0008270; GO:0008432; GO:0016020; GO:0018105; GO:0031434; GO:0032232; GO:0042787; GO:0043065; GO:0043406; GO:0043507; GO:0045944; GO:0046625; GO:0046777; GO:0050434; GO:0051019; GO:0051259 0 0 0 PF00069; Q6P829 CHOYP_LOC725565.1.1 m.19064 sp NOSIP_XENTR 55.326 291 120 3 1 281 1 291 2.34E-116 339 NOSIP_XENTR reviewed Nitric oxide synthase-interacting protein (E3 ubiquitin-protein ligase NOSIP) (EC 6.3.2.-) nosip Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 298 multicellular organism development [GO:0007275]; regulation of nitric-oxide synthase activity [GO:0050999] GO:0005634; GO:0005737; GO:0007275; GO:0016874; GO:0050999 0 0 0 PF15906; Q7T102 CHOYP_BRAFLDRAFT_113848.1.1 m.24938 sp CCZ1_XENLA 53.863 466 200 9 8 465 13 471 2.34E-179 513 CCZ1_XENLA reviewed Vacuolar fusion protein CCZ1 homolog ccz1 Xenopus laevis (African clawed frog) 471 0 GO:0005765 0 0 0 PF08217; Q80SX5 CHOYP_LOC100902588.1.2 m.6509 sp OTOP2_MOUSE 33.333 108 66 1 395 502 94 195 2.34E-12 72.8 OTOP2_MOUSE reviewed Otopetrin-2 Otop2 Mus musculus (Mouse) 563 0 GO:0016021 0 0 0 PF03189; Q80TC5 CHOYP_LOC100489833.1.1 m.12617 sp POGK_MOUSE 39.459 185 109 2 2 184 410 593 2.34E-42 154 POGK_MOUSE reviewed Pogo transposable element with KRAB domain Pogk Kiaa1513 Mus musculus (Mouse) 607 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q86U86 CHOYP_PHUM_PHUM244090.1.1 m.41310 sp PB1_HUMAN 52.475 101 44 2 5 102 1588 1687 2.34E-27 107 PB1_HUMAN reviewed Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 "chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0003682; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0008285; GO:0016569; GO:0090544 0 0 0 PF01426;PF00439;PF00505; Q8CEE7 CHOYP_RDH13.3.3 m.44172 sp RDH13_MOUSE 41.975 324 172 6 21 333 5 323 2.34E-63 208 RDH13_MOUSE reviewed Retinol dehydrogenase 13 (EC 1.1.1.-) Rdh13 Mus musculus (Mouse) 334 eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842] GO:0005739; GO:0009644; GO:0010842; GO:0016491; GO:0042462 0 0 0 PF00106; Q920Q8 CHOYP_LOC100122211.1.1 m.56146 sp NS1BP_MOUSE 34.154 650 400 11 14 652 7 639 2.34E-121 379 NS1BP_MOUSE reviewed Influenza virus NS1A-binding protein homolog (NS1-BP) (NS1-binding protein homolog) (Kelch family protein Nd1-L) (ND1-L2) (Nd1-S) Ivns1abp Kiaa0850 Nd1 Nd1L Nd1S Ns1 Ns1bp Mus musculus (Mouse) 642 negative regulation of intrinsic apoptotic signaling pathway [GO:2001243] GO:0005634; GO:0005737; GO:0015629; GO:2001243 0 0 0 PF07707;PF00651;PF01344; Q96IG2 CHOYP_BRAFLDRAFT_121756.1.1 m.35388 sp FXL20_HUMAN 22.051 390 206 18 22 351 64 415 2.34E-06 53.1 FXL20_HUMAN reviewed F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) FBXL20 FBL2 Homo sapiens (Human) 436 behavioral fear response [GO:0001662] GO:0001662; GO:0005737 0 0 0 PF12937;PF13516; Q96M20 CHOYP_CSK21.2.2 m.28274 sp CNBD2_HUMAN 24.324 222 152 6 305 516 96 311 2.34E-08 61.2 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q99933 CHOYP_LOC100561123.26.28 m.57595 sp BAG1_HUMAN 36.842 171 107 1 43 213 170 339 2.34E-29 114 BAG1_HUMAN reviewed BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) BAG1 HAP Homo sapiens (Human) 345 apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; chaperone cofactor-dependent protein refolding [GO:0070389]; negative regulation of apoptotic process [GO:0043066]; regulation of cellular response to heat [GO:1900034] GO:0000774; GO:0005057; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007166; GO:0043066; GO:0070389; GO:1900034 0 0 0 PF02179;PF00240; Q99J23 CHOYP_BRAFLDRAFT_63587.1.2 m.17521 sp GHDC_MOUSE 29.329 566 330 11 37 601 36 532 2.34E-66 228 GHDC_MOUSE reviewed GH3 domain-containing protein Ghdc D11lgp1e Lgp1 Mus musculus (Mouse) 532 0 GO:0005635; GO:0005783; GO:0016020 0 0 0 PF03321; Q9C0C9 CHOYP_AAEL_AAEL006073.1.1 m.55923 sp UBE2O_HUMAN 42.493 353 155 3 1043 1348 929 1280 2.34E-76 281 UBE2O_HUMAN reviewed (E3-independent) E2 ubiquitin-conjugating enzyme (EC 2.3.2.24) (E2/E3 hybrid ubiquitin-protein ligase UBE2O) (Ubiquitin carrier protein O) (Ubiquitin-conjugating enzyme E2 O) (Ubiquitin-conjugating enzyme E2 of 230 kDa) (Ubiquitin-conjugating enzyme E2-230K) (Ubiquitin-protein ligase O) UBE2O KIAA1734 Homo sapiens (Human) 1292 "positive regulation of BMP signaling pathway [GO:0030513]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0004842; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006513; GO:0030513; GO:0031625; GO:0042147; GO:0044822; GO:0061630; GO:0061631; GO:0070534 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q9CX66 CHOYP_LOC100545511.1.1 m.19200 sp CL045_MOUSE 28.571 119 78 2 4 115 12 130 2.34E-07 51.6 CL045_MOUSE reviewed Uncharacterized protein C12orf45 homolog D10Wsu102e Mus musculus (Mouse) 185 0 0 0 0 0 PF15370; Q9H4B6 CHOYP_BRAFLDRAFT_117824.1.1 m.25899 sp SAV1_HUMAN 46.61 236 111 4 205 437 154 377 2.34E-63 220 SAV1_HUMAN reviewed Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) SAV1 WW45 Homo sapiens (Human) 383 hair follicle development [GO:0001942]; hippo signaling [GO:0035329]; intestinal epithelial cell differentiation [GO:0060575]; keratinocyte differentiation [GO:0030216]; lung epithelial cell differentiation [GO:0060487]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of epithelial cell proliferation [GO:0050680]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein stabilization [GO:0050821]; regulation of stem cell population maintenance [GO:2000036]; ventricular septum morphogenesis [GO:0060412] GO:0001942; GO:0005634; GO:0005737; GO:0005829; GO:0030216; GO:0035329; GO:0043065; GO:0045600; GO:0050680; GO:0050821; GO:0051091; GO:0060044; GO:0060412; GO:0060487; GO:0060575; GO:2000036 0 0 0 PF00397; Q9M0X9 CHOYP_contig_015554 m.18151 sp 4CLL7_ARATH 29.68 219 138 6 2 218 340 544 2.34E-16 80.9 4CLL7_ARATH reviewed 4-coumarate--CoA ligase-like 7 (EC 6.2.1.-) (4-coumarate--CoA ligase isoform 6) (At4CL6) 4CLL7 At4g05160 C17L7.80 Arabidopsis thaliana (Mouse-ear cress) 544 fatty acid biosynthetic process [GO:0006633]; jasmonic acid biosynthetic process [GO:0009695]; oxylipin biosynthetic process [GO:0031408] GO:0004321; GO:0005524; GO:0005777; GO:0006633; GO:0009695; GO:0016874; GO:0031408 0 0 0 PF00501;PF13193; Q9NU02 CHOYP_ANKRD5.2.2 m.38166 sp ANKE1_HUMAN 37.079 89 56 0 48 136 682 770 2.34E-14 72 ANKE1_HUMAN reviewed Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) ANKEF1 ANKRD5 Homo sapiens (Human) 776 0 GO:0005509 0 0 0 PF00023;PF12796; Q9NZJ4 CHOYP_BRAFLDRAFT_67666.3.6 m.37695 sp SACS_HUMAN 29.932 147 90 5 120 259 1868 2008 2.34E-11 67.4 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9ULJ7 CHOYP_LOC581927.9.27 m.31886 sp ANR50_HUMAN 31.494 616 358 20 573 1163 525 1101 2.34E-52 205 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VFD5 CHOYP_PERMA_0370.1.1 m.41998 sp FEM1A_DROME 34.135 208 94 7 818 1013 44 220 2.34E-16 87.4 FEM1A_DROME reviewed Protein fem-1 homolog CG6966 CG6966 Drosophila melanogaster (Fruit fly) 664 regulation of ubiquitin-protein transferase activity [GO:0051438] GO:0004842; GO:0051438 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF13606; Q9W6B4 CHOYP_TIMP2.3.3 m.49639 sp TIMP3_SCYTO 23.301 206 130 6 13 209 18 204 2.34E-08 55.8 TIMP3_SCYTO reviewed Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Scyliorhinus torazame (Cloudy catshark) 214 0 GO:0005578; GO:0008191; GO:0046872 0 0 0 PF00965; Q9Y2S2 CHOYP_DGRI_GH12278.1.1 m.5056 sp CRYL1_HUMAN 46.855 318 167 1 3 318 2 319 2.34E-100 300 CRYL1_HUMAN reviewed Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) CRYL1 CRY Homo sapiens (Human) 319 fatty acid metabolic process [GO:0006631]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640] GO:0003857; GO:0005634; GO:0005730; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0006631; GO:0019640; GO:0042803; GO:0050104; GO:0070062; GO:0070403 0 0 0 PF00725;PF02737; Q9Y6R7 CHOYP_LOC580187.4.4 m.52196 sp FCGBP_HUMAN 23.729 413 290 12 196 596 21 420 2.34E-18 93.6 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A7MBH5 CHOYP_BRAFLDRAFT_120788.1.1 m.48464 sp CC151_BOVIN 25.634 355 254 4 12 356 194 548 2.35E-23 104 CC151_BOVIN reviewed Coiled-coil domain-containing protein 151 CCDC151 Bos taurus (Bovine) 621 cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017] GO:0003341; GO:0005814; GO:0005929; GO:0005930; GO:0007368; GO:0036064; GO:0036158; GO:1902017 0 0 0 0 D2GXS7 CHOYP_TRIM2.55.59 m.60184 sp TRIM2_AILME 34.375 96 59 3 34 126 622 716 2.35E-08 54.3 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2YVK5 CHOYP_SI_CH211-125E6.14.2.2 m.55500 sp LECM_NOTSC 34.328 134 81 3 102 229 26 158 2.35E-17 79.3 LECM_NOTSC reviewed C-type lectin mannose-binding isoform (CTL) (Venom C-type lectin mannose binding isoform 1) 0 Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake) 158 0 GO:0005576; GO:0030246; GO:0046872 0 0 0 PF00059; D3YXG0 CHOYP_HSPG2.4.4 m.22596 sp HMCN1_MOUSE 26.208 1221 744 53 88 1262 521 1630 2.35E-65 250 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D4A1J4 CHOYP_BDH2.2.2 m.57286 sp BDH2_RAT 66.495 194 64 1 137 330 21 213 2.35E-89 270 BDH2_RAT reviewed 3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.-) (EC 1.1.1.30) (Dehydrogenase/reductase SDR family member 6) (R-beta-hydroxybutyrate dehydrogenase) Bdh2 Dhrs6 Rattus norvegicus (Rat) 245 heme metabolic process [GO:0042168]; iron ion homeostasis [GO:0055072]; siderophore biosynthetic process [GO:0019290] GO:0003858; GO:0005737; GO:0016628; GO:0019290; GO:0042168; GO:0055072 PATHWAY: Siderophore biosynthesis. 0 0 0 O15315 CHOYP_RAD51B.1.1 m.26879 sp RA51B_HUMAN 53.431 204 86 3 1 195 143 346 2.35E-65 209 RA51B_HUMAN reviewed DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1) RAD51B RAD51L1 REC2 Homo sapiens (Human) 384 blastocyst growth [GO:0001832]; blood coagulation [GO:0007596]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via homologous recombination [GO:0000724]; meiotic DNA recombinase assembly [GO:0000707]; mitotic recombination [GO:0006312]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; somite development [GO:0061053]; strand displacement [GO:0000732]; strand invasion [GO:0042148] GO:0000150; GO:0000707; GO:0000724; GO:0000731; GO:0000732; GO:0001832; GO:0003677; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0006281; GO:0006310; GO:0006312; GO:0007131; GO:0007596; GO:0008094; GO:0008284; GO:0010212; GO:0010971; GO:0033063; GO:0042148; GO:0061053 0 0 0 PF08423; O15553 CHOYP_TRIADDRAFT_23736.1.1 m.32258 sp MEFV_HUMAN 37.931 58 36 0 61 118 374 431 2.35E-06 48.5 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; P80416 CHOYP_CSTA.1.3 m.6422 sp CYTA_BOVIN 37.255 102 56 2 24 122 2 98 2.35E-17 74.3 CYTA_BOVIN reviewed "Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]" CSTA STF1 Bos taurus (Bovine) 98 0 GO:0004869; GO:0005737 0 0 0 PF00031; Q00194 CHOYP_LOC656479.1.1 m.26617 sp CNGA1_BOVIN 32.258 155 88 2 79 233 156 293 2.35E-18 86.7 CNGA1_BOVIN reviewed "cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)" CNGA1 CNCG CNCG1 Bos taurus (Bovine) 690 cation transport [GO:0006812]; regulation of membrane potential [GO:0042391]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0001750; GO:0005222; GO:0005223; GO:0005249; GO:0005887; GO:0006812; GO:0007601; GO:0030553; GO:0042391; GO:0042622; GO:0050896; GO:1902495 0 0 0 PF16526;PF00027;PF00520; Q1JQA5 CHOYP_BRAFLDRAFT_211853.1.1 m.18681 sp NENF_BOVIN 50.467 107 53 0 57 163 33 139 2.35E-34 122 NENF_BOVIN reviewed Neudesin (Neuron-derived neurotrophic factor) (SCIRP10-related protein) (Spinal cord injury-related protein 10) NENF Bos taurus (Bovine) 169 negative regulation of appetite [GO:0032099]; positive regulation of MAPK cascade [GO:0043410] GO:0005615; GO:0005654; GO:0012505; GO:0016020; GO:0032099; GO:0043410; GO:0046872 0 0 0 PF00173; Q1LZF1 CHOYP_PAX6.1.1 m.63129 sp PAX6_BOVIN 59.958 472 111 17 41 488 5 422 2.35E-171 491 PAX6_BOVIN reviewed Paired box protein Pax-6 (Oculorhombin) PAX6 Bos taurus (Bovine) 422 astrocyte differentiation [GO:0048708]; axon guidance [GO:0007411]; blood vessel development [GO:0001568]; cell fate determination [GO:0001709]; cerebral cortex regionalization [GO:0021796]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; cornea development in camera-type eye [GO:0061303]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; establishment of mitotic spindle orientation [GO:0000132]; eye photoreceptor cell development [GO:0042462]; forebrain anterior/posterior pattern specification [GO:0021797]; forebrain dorsal/ventral pattern formation [GO:0021798]; forebrain-midbrain boundary formation [GO:0021905]; glucose homeostasis [GO:0042593]; iris morphogenesis [GO:0061072]; keratinocyte differentiation [GO:0030216]; lacrimal gland development [GO:0032808]; lens development in camera-type eye [GO:0002088]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein phosphorylation [GO:0001933]; neuron migration [GO:0001764]; oligodendrocyte cell fate specification [GO:0021778]; pancreatic A cell development [GO:0003322]; pituitary gland development [GO:0021983]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of neuroblast proliferation [GO:0002052]; protein localization to organelle [GO:0033365]; regulation of asymmetric cell division [GO:0009786]; regulation of cell migration [GO:0030334]; regulation of timing of cell differentiation [GO:0048505]; regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment [GO:0021918]; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification [GO:0021912]; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification [GO:0021913]; response to wounding [GO:0009611]; retina development in camera-type eye [GO:0060041]; salivary gland morphogenesis [GO:0007435]; signal transduction involved in regulation of gene expression [GO:0023019]; smoothened signaling pathway [GO:0007224]; type B pancreatic cell differentiation [GO:0003309] GO:0000132; GO:0000790; GO:0000978; GO:0000979; GO:0001077; GO:0001227; GO:0001568; GO:0001709; GO:0001764; GO:0001933; GO:0002052; GO:0002088; GO:0003309; GO:0003322; GO:0003682; GO:0004842; GO:0005654; GO:0005737; GO:0007224; GO:0007411; GO:0007435; GO:0009611; GO:0009786; GO:0009950; GO:0021778; GO:0021796; GO:0021797; GO:0021798; GO:0021902; GO:0021905; GO:0021912; GO:0021913; GO:0021918; GO:0021983; GO:0023019; GO:0030216; GO:0030334; GO:0030858; GO:0032808; GO:0033365; GO:0042462; GO:0042593; GO:0045665; GO:0048505; GO:0048596; GO:0048708; GO:0050680; GO:0050768; GO:0060041; GO:0061072; GO:0061303; GO:2000178 0 0 0 PF00046;PF00292; Q20930 CHOYP_LOAG_00377.4.4 m.57745 sp MIG17_CAEEL 34.074 270 149 16 267 514 198 460 2.35E-29 126 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q24297 CHOYP_ISCW_ISCW012036.1.1 m.27987 sp RUXF_DROME 81.395 86 16 0 33 118 3 88 2.35E-48 152 RUXF_DROME reviewed Small nuclear ribonucleoprotein F (snRNP-F) (Membrane-associated protein Deb-B) (Sm protein F) (Sm-F) (SmF) SmF DebB CG16792 Drosophila melanogaster (Fruit fly) 88 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003723; GO:0005681; GO:0005685; GO:0005732; GO:0007052; GO:0030532; GO:0071011; GO:0071013 0 0 0 PF01423; Q503Q1 CHOYP_BRAFLDRAFT_204736.1.2 m.27864 sp MIEAP_DANRE 43.496 492 262 4 12 490 1 489 2.35E-134 400 MIEAP_DANRE reviewed Mitochondria-eating protein (Spermatogenesis-associated protein 18) spata18 mieap si:ch73-16a12.2 zgc:110352 Danio rerio (Zebrafish) (Brachydanio rerio) 490 cellular response to DNA damage stimulus [GO:0006974]; mitochondrial protein catabolic process [GO:0035694]; mitophagy by induced vacuole formation [GO:0035695] GO:0005737; GO:0005741; GO:0006974; GO:0035694; GO:0035695; GO:0043231 0 0 0 PF16026; Q503V3 CHOYP_LOC100376246.1.1 m.14101 sp CL049_DANRE 47.783 203 98 3 1 202 1 196 2.35E-60 190 CL049_DANRE reviewed UPF0454 protein C12orf49 homolog zgc:110063 Danio rerio (Zebrafish) (Brachydanio rerio) 199 0 GO:0005576 0 0 0 PF10218; Q5BIM1 CHOYP_LOC582347.1.2 m.24069 sp TRI45_BOVIN 22.414 232 175 4 1 228 122 352 2.35E-10 67 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5EA80 CHOYP_PGTA.1.1 m.43418 sp PGTA_BOVIN 46.154 572 288 9 1 561 1 563 2.35E-166 487 PGTA_BOVIN reviewed Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha) RABGGTA Bos taurus (Bovine) 567 protein geranylgeranylation [GO:0018344] GO:0004663; GO:0005968; GO:0008270; GO:0017137; GO:0018344 0 0 0 PF01239;PF07711; Q6AY22 CHOYP_LOC100183485.1.1 m.9978 sp SPAT1_RAT 38.947 190 109 4 697 885 246 429 2.35E-28 122 SPAT1_RAT reviewed Spermatogenesis-associated protein 1 Spata1 Rattus norvegicus (Rat) 444 0 0 0 0 0 PF15743; Q6AZB8 CHOYP_LOC100537368.2.2 m.31641 sp HARB1_DANRE 37.736 212 123 4 14 217 138 348 2.35E-42 149 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6ZNA1 CHOYP_ZNF624.1.1 m.45743 sp ZN836_HUMAN 28.767 511 300 15 894 1378 216 688 2.35E-40 166 ZN836_HUMAN reviewed Zinc finger protein 836 ZNF836 Homo sapiens (Human) 936 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q6ZUG5 CHOYP_LOC100373146.2.2 m.27802 sp YC006_HUMAN 40.338 414 232 5 525 930 2 408 2.35E-98 330 YC006_HUMAN reviewed Uncharacterized protein FLJ43738 0 Homo sapiens (Human) 572 0 0 0 0 0 0 Q70FJ1 CHOYP_LOC100186299.4.6 m.11837 sp AKAP9_MOUSE 33.619 467 283 8 1036 1501 1678 2118 2.35E-43 179 AKAP9_MOUSE reviewed A-kinase anchor protein 9 (AKAP-9) (Protein kinase A-anchoring protein 9) (PRKA9) Akap9 Kiaa0803 Mus musculus (Mouse) 3797 microtubule nucleation [GO:0007020]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] GO:0000242; GO:0005737; GO:0005794; GO:0005795; GO:0005813; GO:0007020; GO:0007165; GO:0007283; GO:0036064; GO:0060009 0 0 0 PF10495; Q7TPV2 CHOYP_BRAFLDRAFT_86714.1.1 m.20395 sp DZIP3_MOUSE 33.523 176 93 8 85 245 405 571 2.35E-10 68.9 DZIP3_MOUSE reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) 1204 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q86YH6 CHOYP_DLP1.1.1 m.40279 sp DLP1_HUMAN 48.603 358 173 7 27 377 42 395 2.35E-104 316 DLP1_HUMAN reviewed Decaprenyl-diphosphate synthase subunit 2 (EC 2.5.1.91) (All-trans-decaprenyl-diphosphate synthase subunit 2) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) PDSS2 C6orf210 DLP1 Homo sapiens (Human) 399 isoprenoid biosynthetic process [GO:0008299]; protein heterotetramerization [GO:0051290]; regulation of body fluid levels [GO:0050878]; ubiquinone biosynthetic process [GO:0006744] GO:0000010; GO:0005737; GO:0005759; GO:0006744; GO:0008299; GO:0046982; GO:0050347; GO:0050878; GO:0051290; GO:1990234 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. 0 0 PF00348; Q8C8H8 CHOYP_KY.1.5 m.9721 sp KY_MOUSE 26.477 491 328 14 64 543 145 613 2.35E-39 156 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.15.34 m.35542 sp VWDE_HUMAN 23.883 649 379 37 6 593 6 600 2.35E-16 88.6 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NDI1 CHOYP_LOC100122021.1.1 m.17105 sp EHBP1_HUMAN 59.459 148 60 0 200 347 441 588 2.35E-56 215 EHBP1_HUMAN reviewed EH domain-binding protein 1 EHBP1 KIAA0903 NACSIN Homo sapiens (Human) 1231 0 GO:0005737; GO:0005886 0 0 0 PF00307;PF12130;PF10358; Q8TCB0 CHOYP_SI_CH211-197G15.10.4.7 m.37219 sp IFI44_HUMAN 23.488 281 188 8 113 377 153 422 2.35E-06 53.1 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q90YV5 CHOYP_RL13.3.4 m.34510 sp RL13_ICTPU 60.606 66 26 0 1 66 146 211 2.35E-15 73.6 RL13_ICTPU reviewed 60S ribosomal protein L13 rpl13 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 211 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01294; Q96N64 CHOYP_BRAFLDRAFT_124247.1.1 m.46149 sp PWP2A_HUMAN 49.593 123 62 0 619 741 632 754 2.35E-35 147 PWP2A_HUMAN reviewed PWWP domain-containing protein 2A PWWP2A KIAA1935 MST101 Homo sapiens (Human) 755 0 0 0 0 0 PF00855; Q9EPR2 CHOYP_DPER_GL25215.1.1 m.5799 sp PG12A_MOUSE 41.837 98 53 3 11 105 88 184 2.35E-21 89.4 PG12A_MOUSE reviewed Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) Pla2g12a Pla2g12 Mus musculus (Mouse) 192 lipid catabolic process [GO:0016042] GO:0004623; GO:0005509; GO:0005576; GO:0005622; GO:0005783; GO:0005794; GO:0016042 0 0 0 PF06951; Q9JIX0 CHOYP_LOC100374772.1.4 m.30631 sp ENY2_MOUSE 84.946 93 14 0 8 100 8 100 2.35E-55 169 ENY2_MOUSE reviewed Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) Eny2 Mus musculus (Mouse) 101 "histone deubiquitination [GO:0016578]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of transcription, DNA-templated [GO:0045893]; protein transport [GO:0015031]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]" GO:0000124; GO:0003682; GO:0003713; GO:0005643; GO:0006357; GO:0006368; GO:0015031; GO:0016578; GO:0016973; GO:0030374; GO:0045893; GO:0061179; GO:0070390; GO:0071819 0 0 0 0 Q9JIX0 CHOYP_LOC100374772.4.4 m.66489 sp ENY2_MOUSE 84.946 93 14 0 8 100 8 100 2.35E-55 169 ENY2_MOUSE reviewed Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) Eny2 Mus musculus (Mouse) 101 "histone deubiquitination [GO:0016578]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of transcription, DNA-templated [GO:0045893]; protein transport [GO:0015031]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]" GO:0000124; GO:0003682; GO:0003713; GO:0005643; GO:0006357; GO:0006368; GO:0015031; GO:0016578; GO:0016973; GO:0030374; GO:0045893; GO:0061179; GO:0070390; GO:0071819 0 0 0 0 Q9PW71 CHOYP_LOC100369648.1.1 m.23419 sp DUS4_CHICK 43.548 310 154 4 8 302 12 315 2.35E-83 261 DUS4_CHICK reviewed Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) DUSP4 MKP2 Gallus gallus (Chicken) 375 dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; inactivation of MAPK activity [GO:0000188]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0000188; GO:0001706; GO:0004725; GO:0005634; GO:0008330; GO:0016311; GO:0016791; GO:0017017; GO:0035335; GO:0035970; GO:0070373; GO:1990439 0 0 0 PF00782;PF00581; Q9UPZ3 CHOYP_HPS5.1.1 m.28250 sp HPS5_HUMAN 32.543 464 292 9 4 458 13 464 2.35E-63 240 HPS5_HUMAN reviewed Hermansky-Pudlak syndrome 5 protein (Alpha-integrin-binding protein 63) (Ruby-eye protein 2 homolog) (Ru2) HPS5 AIBP63 KIAA1017 Homo sapiens (Human) 1129 blood coagulation [GO:0007596]; organelle organization [GO:0006996]; pigmentation [GO:0043473] GO:0006996; GO:0007596; GO:0031084; GO:0043473 0 0 0 0 Q9W2H1 CHOYP_ISCW_ISCW020476.1.1 m.60219 sp TM2D1_DROME 50 176 73 4 20 191 14 178 2.35E-52 168 TM2D1_DROME reviewed TM2 domain-containing protein CG10795 CG10795 Drosophila melanogaster (Fruit fly) 178 0 GO:0016021 0 0 0 PF05154; A0JNU3 CHOYP_LOC752844.2.4 m.5201 sp LPP60_MOUSE 58.974 39 16 0 59 97 430 468 2.36E-06 47.4 LPP60_MOUSE reviewed 60 kDa lysophospholipase (EC 3.1.1.5) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47)] Aspg Mus musculus (Mouse) 564 cellular amino acid metabolic process [GO:0006520]; lipid catabolic process [GO:0016042] GO:0003847; GO:0004067; GO:0004622; GO:0006520; GO:0016042 0 0 0 PF00710; A2AV25 CHOYP_TL5A.2.3 m.50563 sp FBCD1_MOUSE 53.241 216 91 4 39 245 239 453 2.36E-71 228 FBCD1_MOUSE reviewed Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) 459 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; B2RUP2 CHOYP_BAIP3.1.1 m.24878 sp UN13D_MOUSE 23.81 1092 742 30 169 1240 54 1075 2.36E-52 204 UN13D_MOUSE reviewed Protein unc-13 homolog D (Munc13-4) Unc13d Mus musculus (Mouse) 1085 defense response to virus [GO:0051607]; germinal center formation [GO:0002467]; granuloma formation [GO:0002432]; natural killer cell degranulation [GO:0043320]; phagocytosis [GO:0006909]; positive regulation of exocytosis [GO:0045921]; positive regulation of regulated secretory pathway [GO:1903307]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of mast cell degranulation [GO:0043304] GO:0002432; GO:0002467; GO:0005764; GO:0005770; GO:0006909; GO:0016020; GO:0017137; GO:0033093; GO:0043304; GO:0043320; GO:0045921; GO:0051607; GO:0055037; GO:0070382; GO:1900026; GO:1903307 0 0 0 PF00168;PF10540; H2QII6 CHOYP_PHUM_PHUM477850.1.1 m.19067 sp RBP2_PANTR 28.671 715 468 20 18 714 3 693 2.36E-77 291 RBP2_PANTR reviewed E3 SUMO-protein ligase RanBP2 (EC 6.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) RANBP2 NUP358 Pan troglodytes (Chimpanzee) 3224 mRNA transport [GO:0051028]; negative regulation of glucokinase activity [GO:0033132]; NLS-bearing protein import into nucleus [GO:0006607]; protein folding [GO:0006457]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis involved in cellular glucose homeostasis [GO:0090526] GO:0003723; GO:0003755; GO:0005643; GO:0005739; GO:0005875; GO:0006457; GO:0006607; GO:0008270; GO:0008536; GO:0016874; GO:0016925; GO:0031965; GO:0033132; GO:0042405; GO:0044615; GO:0051028; GO:0090526 PATHWAY: Protein modification; protein sumoylation. 0 0 PF12185;PF00160;PF00638;PF00641; O00237 CHOYP_RN103.1.1 m.60665 sp RN103_HUMAN 33.815 692 377 16 1 627 1 676 2.36E-108 344 RN103_HUMAN reviewed E3 ubiquitin-protein ligase RNF103 (EC 6.3.2.-) (KF-1) (hKF-1) (RING finger protein 103) (Zinc finger protein 103 homolog) (Zfp-103) RNF103 ZFP103 Homo sapiens (Human) 685 central nervous system development [GO:0007417]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005783; GO:0005789; GO:0007417; GO:0008270; GO:0016021; GO:0016567; GO:0016874; GO:0030433 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; O00341 CHOYP_LOC101064448.1.1 m.41152 sp EAA5_HUMAN 38.983 118 65 2 1 114 56 170 2.36E-19 85.1 EAA5_HUMAN reviewed Excitatory amino acid transporter 5 (Retinal glutamate transporter) (Solute carrier family 1 member 7) SLC1A7 EAAT5 Homo sapiens (Human) 560 dicarboxylic acid transport [GO:0006835]; glutamate secretion [GO:0014047]; ion transport [GO:0006811] GO:0005313; GO:0005314; GO:0005886; GO:0006811; GO:0006835; GO:0014047; GO:0015171; GO:0016021 0 0 0 PF00375; O42387 CHOYP_RS24.6.6 m.63686 sp RS24_TAKRU 81.818 99 18 0 1 99 13 111 2.36E-57 176 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O43736 CHOYP_BRAFLDRAFT_120146.1.1 m.26173 sp ITM2A_HUMAN 29.487 234 114 10 9 240 35 219 2.36E-14 74.7 ITM2A_HUMAN reviewed Integral membrane protein 2A (Protein E25) ITM2A UNQ603/PRO1189 Homo sapiens (Human) 263 negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399] GO:0001540; GO:0005794; GO:0005886; GO:0007399; GO:0016021; GO:0042985; GO:0070062 0 0 0 PF04089; O75095 CHOYP_MEGF6.36.59 m.43203 sp MEGF6_HUMAN 37.766 940 461 21 1276 2109 511 1432 2.36E-152 518 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75096 CHOYP_LOC101243071.1.2 m.34731 sp LRP4_HUMAN 24.079 814 531 32 15 794 591 1351 2.36E-38 161 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; O75382 CHOYP_BRAFLDRAFT_69798.3.22 m.27376 sp TRIM3_HUMAN 27.692 130 88 2 7 130 614 743 2.36E-10 61.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88873 CHOYP_GMEB1.1.1 m.8284 sp GMEB2_RAT 26.25 320 180 8 25 338 90 359 2.36E-27 118 GMEB2_RAT reviewed Glucocorticoid modulatory element-binding protein 2 (GMEB-2) Gmeb2 Rattus norvegicus (Rat) 529 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003713; GO:0005634; GO:0005737; GO:0006351; GO:0006357; GO:0046872 0 0 0 PF01342; O93209 CHOYP_LOC100493347.1.2 m.43222 sp POL_FFV 29.143 175 110 3 517 691 241 401 2.36E-08 62 POL_FFV reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Feline foamy virus (FFV) (Feline syncytial virus) 1156 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; P02434 CHOYP_R35A.1.1 m.5768 sp RL35A_XENLA 71.765 85 23 1 33 117 3 86 2.36E-37 125 RL35A_XENLA reviewed 60S ribosomal protein L35a (L32) rpl35a Xenopus laevis (African clawed frog) 110 translation [GO:0006412] GO:0000049; GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01247; P04323 CHOYP_LOC754648.3.3 m.54476 sp POL3_DROME 41.176 442 237 7 931 1360 194 624 2.36E-96 337 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P10079 CHOYP_BRAFLDRAFT_125860.1.1 m.21661 sp FBP1_STRPU 54.651 258 117 0 1 258 184 441 2.36E-85 286 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10394 CHOYP_LOC100535305.2.2 m.41418 sp POL4_DROME 26.144 306 211 5 123 419 893 1192 2.36E-29 124 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P16056 CHOYP_MET.1.2 m.48156 sp MET_MOUSE 31.01 1148 663 37 221 1295 247 1338 2.36E-137 458 MET_MOUSE reviewed Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) Met Mus musculus (Mouse) 1379 activation of MAPK activity [GO:0000187]; adult behavior [GO:0030534]; brain development [GO:0007420]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; chemical synaptic transmission [GO:0007268]; endothelial cell morphogenesis [GO:0001886]; excitatory postsynaptic potential [GO:0060079]; glucose homeostasis [GO:0042593]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; liver development [GO:0001889]; modulation of synaptic transmission [GO:0050804]; muscle cell migration [GO:0014812]; muscle organ development [GO:0007517]; myoblast proliferation [GO:0051450]; myotube differentiation [GO:0014902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of transforming growth factor beta production [GO:0071635]; placenta development [GO:0001890]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of glucose transport [GO:0010828]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777]; reactive oxygen species metabolic process [GO:0072593]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of interleukin-6 production [GO:0032675]; semaphorin-plexin signaling pathway [GO:0071526]; skeletal muscle tissue development [GO:0007519] GO:0000187; GO:0001886; GO:0001889; GO:0001890; GO:0004672; GO:0005008; GO:0005524; GO:0007268; GO:0007420; GO:0007517; GO:0007519; GO:0009925; GO:0009986; GO:0010629; GO:0010828; GO:0014812; GO:0014902; GO:0016020; GO:0016021; GO:0019903; GO:0030534; GO:0032675; GO:0042593; GO:0045944; GO:0046777; GO:0048012; GO:0048754; GO:0050804; GO:0050918; GO:0051450; GO:0055013; GO:0060048; GO:0060079; GO:0060665; GO:0071526; GO:0071635; GO:0072593; GO:0098794; GO:1900407; GO:1900745; GO:1901299; GO:2001028 0 0 0 PF07714;PF01437;PF01403;PF01833; P16157 CHOYP_TVAG_470020.8.8 m.61544 sp ANK1_HUMAN 35.623 626 374 1 87 683 32 657 2.36E-107 361 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20918 CHOYP_PLMN.3.11 m.25582 sp PLMN_MOUSE 37.534 373 190 13 22 359 98 462 2.36E-61 215 PLMN_MOUSE reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Mus musculus (Mouse) 812 blood coagulation [GO:0007596]; extracellular matrix disassembly [GO:0022617]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fibrinolysis [GO:0051918]; positive regulation of fibrinolysis [GO:0051919]; proteolysis involved in cellular protein catabolic process [GO:0051603]; tissue regeneration [GO:0042246]; tissue remodeling [GO:0048771]; trophoblast giant cell differentiation [GO:0060707] GO:0004252; GO:0005102; GO:0005576; GO:0005615; GO:0007596; GO:0009986; GO:0010812; GO:0016525; GO:0019897; GO:0019904; GO:0022617; GO:0031232; GO:0034185; GO:0042246; GO:0042730; GO:0043231; GO:0044218; GO:0045445; GO:0046716; GO:0048771; GO:0051603; GO:0051918; GO:0051919; GO:0060707; GO:0060716; GO:0070062; GO:0071674; GO:0072562 0 0 cd00190; PF00051;PF00024;PF00089; P27473 CHOYP_LOC101165968.3.7 m.49147 sp IFI44_PANTR 31.776 428 260 9 26 451 26 423 2.36E-58 202 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P50429 CHOYP_BRAFLDRAFT_206907.11.11 m.60959 sp ARSB_MOUSE 41.458 480 238 7 21 462 42 516 2.36E-130 391 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; Q01528 CHOYP_NEMVEDRAFT_V1G118229.1.1 m.2332 sp HAAF_LIMPO 44.643 56 31 0 99 154 114 169 2.36E-10 59.3 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q05722 CHOYP_COL12.3.3 m.50672 sp CO9A1_MOUSE 37.2 250 92 8 108 345 444 640 2.36E-16 84.3 CO9A1_MOUSE reviewed Collagen alpha-1(IX) chain Col9a1 Mus musculus (Mouse) 921 cartilage development [GO:0051216]; growth plate cartilage development [GO:0003417]; tissue homeostasis [GO:0001894] GO:0001894; GO:0003417; GO:0005578; GO:0005594; GO:0046872; GO:0051216 0 0 0 PF01391; Q08C93 CHOYP_LOC100729841.1.1 m.1851 sp ABD12_DANRE 42.857 315 177 2 58 371 65 377 2.36E-96 295 ABD12_DANRE reviewed Monoacylglycerol lipase ABHD12 (EC 3.1.1.23) (Abhydrolase domain-containing protein 12) abhd12 si:ch211-79l10.2 zgc:153367 Danio rerio (Zebrafish) (Brachydanio rerio) 382 acylglycerol catabolic process [GO:0046464] GO:0016021; GO:0046464; GO:0047372 0 0 0 PF12146; Q09324 CHOYP_LOC100372744.2.2 m.64789 sp GCNT1_MOUSE 37.875 367 205 8 84 432 55 416 2.36E-79 255 GCNT1_MOUSE reviewed "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)" Gcnt1 Mus musculus (Mouse) 428 cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; protein glycosylation [GO:0006486]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729] GO:0000139; GO:0003829; GO:0005615; GO:0005802; GO:0006486; GO:0009101; GO:0016021; GO:0031985; GO:0032868; GO:0048729; GO:0050901; GO:0060352; GO:0060993 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02485; Q14CB8 CHOYP_LOC660076.1.1 m.10495 sp RHG19_HUMAN 32.627 472 273 14 16 468 20 465 2.36E-52 190 RHG19_HUMAN reviewed Rho GTPase-activating protein 19 (Rho-type GTPase-activating protein 19) ARHGAP19 Homo sapiens (Human) 494 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005634; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00620; Q24151 CHOYP_STAT6.1.1 m.13324 sp STAT_DROME 28.239 301 167 11 233 524 430 690 2.36E-19 97.4 STAT_DROME reviewed Signal transducer and transcription activator (d-STAT) (Protein marelle) Stat92E MARE mrL Stat CG4257 Drosophila melanogaster (Fruit fly) 761 "blastoderm segmentation [GO:0007350]; border follicle cell migration [GO:0007298]; cell dedifferentiation [GO:0043697]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to X-ray [GO:0071481]; compound eye development [GO:0048749]; defense response [GO:0006952]; epithelial cell fate determination, open tracheal system [GO:0007425]; eye-antennal disc morphogenesis [GO:0007455]; germ-line stem cell division [GO:0042078]; germ-line stem cell population maintenance [GO:0030718]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; hindgut morphogenesis [GO:0007442]; humoral immune response [GO:0006959]; imaginal disc-derived wing morphogenesis [GO:0007476]; JAK-STAT cascade [GO:0007259]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; larval somatic muscle development [GO:0007526]; long-term memory [GO:0007616]; negative regulation of antimicrobial humoral response [GO:0008348]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of Wnt signaling pathway [GO:0030178]; nervous system development [GO:0007399]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell stalk formation [GO:0030713]; positive regulation of cell proliferation [GO:0008284]; positive regulation of defense response to virus by host [GO:0002230]; primary sex determination [GO:0007538]; regulation of JAK-STAT cascade [GO:0046425]; segment specification [GO:0007379]; sex determination [GO:0007530]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell division [GO:0017145]; stem cell population maintenance [GO:0019827]" GO:0001077; GO:0002230; GO:0003677; GO:0003700; GO:0004871; GO:0005634; GO:0005737; GO:0006952; GO:0006959; GO:0007259; GO:0007298; GO:0007350; GO:0007379; GO:0007399; GO:0007424; GO:0007425; GO:0007442; GO:0007455; GO:0007476; GO:0007526; GO:0007530; GO:0007538; GO:0007616; GO:0008284; GO:0008348; GO:0017145; GO:0019827; GO:0030097; GO:0030178; GO:0030713; GO:0030718; GO:0030720; GO:0035019; GO:0035167; GO:0035171; GO:0035172; GO:0042078; GO:0043697; GO:0046425; GO:0048103; GO:0048477; GO:0048749; GO:0071222; GO:0071481; GO:2000737 0 0 0 PF00017;PF01017;PF02864;PF02865; Q28727 CHOYP_LOC100119310.1.1 m.22031 sp NTCP2_RABIT 31.269 323 207 6 183 500 30 342 2.36E-45 165 NTCP2_RABIT reviewed "Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)" SLC10A2 NTCP2 Oryctolagus cuniculus (Rabbit) 347 0 GO:0005902; GO:0008508; GO:0016021; GO:0016324 0 0 0 PF01758; Q2T9V8 CHOYP_LOC100556247.1.3 m.18037 sp DTD1_BOVIN 68.269 104 33 0 1 104 45 148 2.36E-49 159 DTD1_BOVIN reviewed D-tyrosyl-tRNA(Tyr) deacylase 1 (EC 3.1.-.-) (DNA-unwinding element-binding protein B) (DUE-B) DTD1 HARS2 Bos taurus (Bovine) 209 D-amino acid catabolic process [GO:0019478]; DNA replication [GO:0006260]; tRNA metabolic process [GO:0006399] GO:0002161; GO:0003677; GO:0005634; GO:0005737; GO:0006260; GO:0006399; GO:0019478; GO:0046872; GO:0051500 0 0 cd00563; PF02580; Q5E9U9 CHOYP_LOC100377135.1.1 m.11135 sp NPRL2_BOVIN 47.368 380 192 3 4 380 6 380 2.36E-120 356 NPRL2_BOVIN reviewed Nitrogen permease regulator 2-like protein (NPR2-like protein) (Tumor suppressor candidate 4) NPRL2 TUSC4 Bos taurus (Bovine) 380 cellular response to amino acid starvation [GO:0034198]; negative regulation of kinase activity [GO:0033673]; negative regulation of TOR signaling [GO:0032007] GO:0004672; GO:0005096; GO:0032007; GO:0033673; GO:0034198; GO:1990130 0 0 0 PF06218; Q5F416 CHOYP_TIPIN.2.2 m.26890 sp TIPIN_CHICK 39.662 237 91 4 73 304 59 248 2.36E-45 162 TIPIN_CHICK reviewed TIMELESS-interacting protein TIPIN RCJMB04_3n6 Gallus gallus (Chicken) 283 cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint [GO:0000076]; intra-S DNA damage checkpoint [GO:0031573]; mitotic nuclear division [GO:0007067]; positive regulation of cell proliferation [GO:0008284]; replication fork protection [GO:0048478] GO:0000076; GO:0000790; GO:0005634; GO:0005737; GO:0007067; GO:0008284; GO:0031573; GO:0044770; GO:0048478; GO:0051301 0 0 0 PF07962; Q5RJ80 CHOYP_LOC100698649.1.8 m.5456 sp CAPR2_DANRE 34.091 132 79 5 178 305 785 912 2.36E-10 65.1 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5XIA3 CHOYP_LCMT2.1.1 m.43651 sp TYW4_RAT 38.5 200 117 4 56 249 480 679 2.36E-31 125 TYW4_RAT reviewed tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase) Lcmt2 Tyw4 Rattus norvegicus (Rat) 686 tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591] GO:0005829; GO:0008175; GO:0008757; GO:0030488; GO:0031591 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 PF04072; Q5ZIJ9 CHOYP_MIB1.4.4 m.64019 sp MIB2_CHICK 33.838 198 111 1 8 185 579 776 2.36E-31 127 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q80X90 CHOYP_LOC100741876.1.1 m.16203 sp FLNB_MOUSE 36.585 82 41 2 5 80 2525 2601 2.36E-07 52.4 FLNB_MOUSE reviewed Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) Flnb Mus musculus (Mouse) 2602 actin cytoskeleton organization [GO:0030036]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; skeletal muscle tissue development [GO:0007519] GO:0001725; GO:0003334; GO:0003382; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0005938; GO:0007519; GO:0030018; GO:0030036; GO:0042802; GO:0044822; GO:0070062 0 0 0 PF00307;PF00630; Q8EUM4 CHOYP_DNAJC4.1.2 m.18060 sp DNAJ_MYCPE 52.239 67 32 0 31 97 1 67 2.36E-15 78.6 DNAJ_MYCPE reviewed Chaperone protein DnaJ dnaJ MYPE8970 Mycoplasma penetrans (strain HF-2) 388 DNA replication [GO:0006260]; protein folding [GO:0006457]; response to heat [GO:0009408] GO:0005524; GO:0005737; GO:0006260; GO:0006457; GO:0008270; GO:0009408 0 0 cd06257; PF00226;PF01556;PF00684; Q8N539 CHOYP_BRAFLDRAFT_252169.2.6 m.20586 sp FBCD1_HUMAN 42.601 223 111 5 175 390 243 455 2.36E-45 166 FBCD1_HUMAN reviewed Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) 461 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q8N554 CHOYP_ZN454.1.1 m.2031 sp ZN276_HUMAN 28.906 128 86 2 979 1106 427 549 2.36E-16 87.8 ZN276_HUMAN reviewed Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477) ZNF276 CENP-Z ZFP276 ZNF477 Homo sapiens (Human) 614 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000776; GO:0000777; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF07776; Q8UWA5 CHOYP_CAH2.1.1 m.42306 sp CAH2_TRIHK 48.837 258 121 5 85 335 5 258 2.36E-81 251 CAH2_TRIHK reviewed Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) ca2 Tribolodon hakonensis (Big-scaled redfin) (Leuciscus hakonensis) 260 one-carbon metabolic process [GO:0006730] GO:0004089; GO:0005737; GO:0005886; GO:0006730; GO:0008270 0 0 0 PF00194; Q92113 CHOYP_LOC100371043.1.5 m.14137 sp CP17A_SQUAC 34.591 477 294 8 72 538 31 499 2.36E-92 294 CP17A_SQUAC reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) 509 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q922J3 CHOYP_LOC100889898.1.1 m.28080 sp CLIP1_MOUSE 38.272 81 46 2 56 136 211 287 2.36E-08 58.5 CLIP1_MOUSE reviewed CAP-Gly domain-containing linker protein 1 (Restin) Clip1 Kiaa4046 Rsn Mus musculus (Mouse) 1391 microtubule bundle formation [GO:0001578]; positive regulation of microtubule polymerization [GO:0031116]; protein transport into plasma membrane raft [GO:0044861] GO:0001578; GO:0001726; GO:0005635; GO:0005737; GO:0005813; GO:0005874; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0030659; GO:0031116; GO:0035371; GO:0044354; GO:0044861; GO:0051010; GO:1990752 0 0 0 PF01302;PF16641; Q99L45 CHOYP_LOC100199030.1.1 m.20309 sp IF2B_MOUSE 50.407 246 98 7 7 232 5 246 2.36E-45 157 IF2B_MOUSE reviewed Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) Eif2s2 Mus musculus (Mouse) 331 in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584] GO:0001701; GO:0002176; GO:0003743; GO:0005737; GO:0008584; GO:0044822; GO:0046872 0 0 0 PF01873; Q9BRZ2 CHOYP_BRAFLDRAFT_75885.5.7 m.45860 sp TRI56_HUMAN 25.789 190 125 6 1 180 94 277 2.36E-10 67 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9ESN6 CHOYP_BRAFLDRAFT_88222.1.6 m.32539 sp TRIM2_MOUSE 29.05 179 110 8 267 439 539 706 2.36E-08 60.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_SIL1.2.2 m.43076 sp TRIM2_MOUSE 28.342 187 125 6 360 541 554 736 2.36E-11 70.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9M9E8 CHOYP_LOC100367039.1.1 m.36512 sp FB92_ARATH 26.692 266 175 6 96 354 126 378 2.36E-20 97.1 FB92_ARATH reviewed F-box protein At1g78280 At1g78280 F3F9.18 Arabidopsis thaliana (Mouse-ear cress) 943 0 GO:0005829 0 0 0 PF01636;PF00646; Q9R1R2 CHOYP_LOC100368020.16.29 m.31965 sp TRIM3_MOUSE 25 120 85 2 57 176 110 224 2.36E-06 52.4 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_205965.13.43 m.32896 sp TRIM2_BOVIN 23.077 143 109 1 32 174 602 743 2.37E-08 56.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6QQL5 CHOYP_LOC100373620.1.1 m.55686 sp CB073_BOVIN 32.639 144 79 5 87 229 54 180 2.37E-09 60.8 CB073_BOVIN reviewed Uncharacterized protein C2orf73 homolog 0 Bos taurus (Bovine) 290 0 0 0 0 0 PF15667; A8WGF7 CHOYP_SPNS1.1.1 m.25402 sp SPNS1_XENTR 55.246 467 191 5 104 562 53 509 2.37E-168 491 SPNS1_XENTR reviewed Protein spinster homolog 1 spns1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 526 locomotion [GO:0040011]; sphingosine-1-phosphate signaling pathway [GO:0003376]; transmembrane transport [GO:0055085] GO:0003376; GO:0005743; GO:0005765; GO:0016021; GO:0031982; GO:0040011; GO:0046624; GO:0055085 0 0 cd06174; PF07690; O35426 CHOYP_XBP1.2.4 m.35638 sp XBP1_MOUSE 43.503 177 78 5 6 163 15 188 2.37E-29 118 XBP1_MOUSE reviewed "X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" Xbp1 Treb5 Mus musculus (Mouse) 267 "adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; autophagy [GO:0006914]; cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation [GO:0002070]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein destabilization [GO:0031648]; protein transport [GO:0015031]; regulation of autophagy [GO:0010506]; regulation of protein stability [GO:0031647]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]" GO:0000122; GO:0000977; GO:0000981; GO:0001047; GO:0001085; GO:0001158; GO:0001525; GO:0001889; GO:0001934; GO:0001935; GO:0002070; GO:0002639; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006351; GO:0006357; GO:0006366; GO:0006511; GO:0006629; GO:0006914; GO:0006990; GO:0007517; GO:0010506; GO:0010508; GO:0010832; GO:0014065; GO:0015031; GO:0016049; GO:0030176; GO:0030968; GO:0031017; GO:0031062; GO:0031490; GO:0031647; GO:0031648; GO:0031670; GO:0032008; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035924; GO:0036312; GO:0042149; GO:0042593; GO:0042632; GO:0042826; GO:0042993; GO:0043066; GO:0043565; GO:0044212; GO:0044389; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051024; GO:0055089; GO:0055092; GO:0060612; GO:0060691; GO:0070059; GO:0071222; GO:0071230; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:1900100; GO:1900102; GO:1900103; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1990418; GO:2000347; GO:2000353; GO:2000778 0 0 0 PF07716; O70277 CHOYP_BRAFLDRAFT_87327.10.13 m.46274 sp TRIM3_RAT 26.316 152 107 3 35 182 593 743 2.37E-09 59.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P32198 CHOYP_CPT1A.1.1 m.53984 sp CPT1A_RAT 36.711 681 385 20 63 712 100 765 2.37E-118 375 CPT1A_RAT reviewed "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" Cpt1a Cpt-1 Cpt1 Rattus norvegicus (Rat) 773 carnitine metabolic process [GO:0009437]; cellular response to fatty acid [GO:0071398]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; glucose metabolic process [GO:0006006]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; protein homooligomerization [GO:0051260]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of fatty acid oxidation [GO:0046320]; regulation of insulin secretion [GO:0050796]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; transport [GO:0006810]; triglyceride metabolic process [GO:0006641] GO:0001676; GO:0004095; GO:0005739; GO:0005741; GO:0005743; GO:0006006; GO:0006635; GO:0006641; GO:0006810; GO:0009437; GO:0014070; GO:0016021; GO:0030855; GO:0031307; GO:0031998; GO:0032000; GO:0042493; GO:0042755; GO:0042802; GO:0043231; GO:0046320; GO:0050796; GO:0051260; GO:0071398; GO:1990698 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00755;PF16484; P70193 CHOYP_CAOG_07758.1.2 m.27528 sp LRIG1_MOUSE 25.16 469 269 11 114 576 124 516 2.37E-18 94.4 LRIG1_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) Lrig1 Mus musculus (Mouse) 1091 innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605] GO:0007605; GO:0016021; GO:0032474; GO:0060384 0 0 0 PF07679;PF13855;PF01463;PF01462; Q08420 CHOYP_LOC100083074.1.1 m.1592 sp SODE_RAT 24.176 182 118 6 49 216 48 223 2.37E-09 58.9 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q09506 CHOYP_ISCW_ISCW004725.1.1 m.9722 sp YQI7_CAEEL 46.825 126 59 1 3 128 5 122 2.37E-35 122 YQI7_CAEEL reviewed Uncharacterized protein C45G9.7 C45G9.7 Caenorhabditis elegans 124 regulation of Wnt signaling pathway [GO:0030111]; Rho protein signal transduction [GO:0007266] GO:0005622; GO:0007266; GO:0030111 0 0 0 PF00595; Q28DR4 CHOYP_LOC100903522.1.3 m.2296 sp H4_XENTR 100 103 0 0 1 103 1 103 2.37E-67 200 H4_XENTR reviewed Histone H4 TGas006m08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 103 "DNA-templated transcription, initiation [GO:0006352]; nucleosome assembly [GO:0006334]" GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0006352 0 0 0 0 Q3SZ85 CHOYP_BRAFLDRAFT_274939.1.1 m.10568 sp PTRD1_BOVIN 56.78 118 49 1 3 118 23 140 2.37E-37 126 PTRD1_BOVIN reviewed Putative peptidyl-tRNA hydrolase PTRHD1 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase domain-containing protein 1) PTRHD1 Bos taurus (Bovine) 140 0 GO:0004045; GO:0070062 0 0 0 PF01981; Q3TBT3 CHOYP_TMEM173.2.5 m.40525 sp STING_MOUSE 30.769 208 134 3 194 399 153 352 2.37E-29 121 STING_MOUSE reviewed Stimulator of interferon genes protein (mSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (MMITA) (Transmembrane protein 173) Tmem173 Eris Mita Mpys Sting Mus musculus (Mouse) 378 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0006915; GO:0008134; GO:0016021; GO:0019901; GO:0031625; GO:0032092; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042802; GO:0042803; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; Q502M6 CHOYP_TVAG_123950.23.31 m.54148 sp ANR29_DANRE 39.153 189 115 0 17 205 31 219 2.37E-38 137 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q567Y6 CHOYP_NEMVEDRAFT_V1G167835.1.1 m.6190 sp IFT22_DANRE 49.462 186 89 2 1 181 1 186 2.37E-63 196 IFT22_DANRE reviewed Intraflagellar transport protein 22 homolog (Rab-like protein 5) ift22 rabl5 zgc:110645 Danio rerio (Zebrafish) (Brachydanio rerio) 187 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0030992 0 0 0 PF08477; Q58DA6 CHOYP_LOC100372949.1.1 m.9344 sp S35A2_BOVIN 52.252 333 156 2 21 352 9 339 2.37E-106 320 S35A2_BOVIN reviewed UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT) SLC35A2 Bos taurus (Bovine) 393 0 GO:0000139; GO:0005351; GO:0016021 0 0 0 PF04142; Q5BJE1 CHOYP_LOC582005.1.1 m.9850 sp CC178_HUMAN 28.632 234 126 5 72 303 82 276 2.37E-17 90.9 CC178_HUMAN reviewed Coiled-coil domain-containing protein 178 CCDC178 C18orf34 Homo sapiens (Human) 867 0 0 0 0 0 0 Q5RFR0 CHOYP_BRAFLDRAFT_125389.1.1 m.62938 sp TTPAL_PONAB 45.583 283 153 1 20 301 18 300 2.37E-83 258 TTPAL_PONAB reviewed Alpha-tocopherol transfer protein-like TTPAL Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 342 0 GO:0005215; GO:0005622; GO:0016020 0 0 0 PF00650;PF03765; Q5SVQ8 CHOYP_ZBT41.1.1 m.47785 sp ZBT41_HUMAN 23.294 674 422 23 24 641 82 716 2.37E-21 103 ZBT41_HUMAN reviewed Zinc finger and BTB domain-containing protein 41 ZBTB41 FRBZ1 Homo sapiens (Human) 909 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF13912; Q5VTB9 CHOYP_RNF220A.1.1 m.12204 sp RN220_HUMAN 46.746 169 68 4 54 220 302 450 2.37E-29 118 RN220_HUMAN reviewed E3 ubiquitin-protein ligase RNF220 (EC 6.3.2.-) (RING finger protein 220) RNF220 C1orf164 Homo sapiens (Human) 566 positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0016874; GO:0051865; GO:0061630; GO:0090263 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15926; Q61555 CHOYP_BRAFLDRAFT_98740.2.7 m.36670 sp FBN2_MOUSE 37.453 267 126 12 60 303 1193 1441 2.37E-28 118 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q6NZJ6 CHOYP_BRAFLDRAFT_277494.1.3 m.54113 sp IF4G1_MOUSE 41.849 595 271 16 422 961 382 956 2.37E-105 366 IF4G1_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) Eif4g1 Mus musculus (Mouse) 1600 behavioral fear response [GO:0001662]; positive regulation of neuron differentiation [GO:0045666]; regulation of translational initiation [GO:0006446] GO:0001662; GO:0003743; GO:0005737; GO:0006446; GO:0008190; GO:0016020; GO:0044822; GO:0045666 0 0 0 PF02847;PF02854;PF02020; Q6PBN2 CHOYP_AIDA.2.2 m.38735 sp AIDA_DANRE 49.434 265 125 3 19 275 33 296 2.37E-78 242 AIDA_DANRE reviewed "Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)" aida zgc:73327 Danio rerio (Zebrafish) (Brachydanio rerio) 303 determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; regulation of protein homodimerization activity [GO:0043496] GO:0009953; GO:0016020; GO:0035091; GO:0043496; GO:0043508; GO:0046329; GO:0048264; GO:2000016 0 0 0 PF14186;PF08910; Q6VVW5 CHOYP_LOC100374171.1.1 m.51669 sp ANPRB_MOUSE 44.444 621 288 14 1 616 468 1036 2.37E-163 501 ANPRB_MOUSE reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) Npr2 Mus musculus (Mouse) 1047 bone development [GO:0060348]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168]; single organism reproductive process [GO:0044702] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007168; GO:0008074; GO:0016941; GO:0017046; GO:0035556; GO:0042562; GO:0042802; GO:0044702; GO:0051447; GO:0060348; GO:0097011; GO:1900194 0 0 0 PF01094;PF00211;PF07714; Q6Y685 CHOYP_TACC1.2.2 m.53512 sp TACC1_MOUSE 47.917 192 94 2 414 599 580 771 2.37E-45 175 TACC1_MOUSE reviewed Transforming acidic coiled-coil-containing protein 1 Tacc1 Mus musculus (Mouse) 774 cell cycle [GO:0007049]; cell division [GO:0051301]; cell proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; interkinetic nuclear migration [GO:0022027]; microtubule cytoskeleton organization [GO:0000226]; neurogenesis [GO:0022008]; regulation of microtubule-based process [GO:0032886] GO:0000226; GO:0005634; GO:0005737; GO:0005815; GO:0007049; GO:0008283; GO:0015630; GO:0019904; GO:0021987; GO:0022008; GO:0022027; GO:0030496; GO:0032886; GO:0045111; GO:0051301 0 0 0 PF05010; Q7ZXX1 CHOYP_CADM2.2.2 m.50428 sp CADM3_XENLA 29.114 237 130 10 126 360 99 299 2.37E-10 66.2 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q803E1 CHOYP_LOC100878601.1.1 m.15486 sp NCBP3_DANRE 39.394 99 60 0 226 324 111 209 2.37E-17 90.5 NCBP3_DANRE reviewed Nuclear cap-binding protein subunit 3 ncbp3 zgc:55870 Danio rerio (Zebrafish) (Brachydanio rerio) 694 7-methylguanosine mRNA capping [GO:0006370]; mRNA transport [GO:0051028] GO:0000166; GO:0000340; GO:0003729; GO:0005634; GO:0005737; GO:0006370; GO:0051028 0 0 0 PF10309; Q8VCM4 CHOYP_LIPT.1.1 m.6624 sp LIPT_MOUSE 40.517 348 189 8 11 352 2 337 2.37E-82 259 LIPT_MOUSE reviewed "Lipoyltransferase 1, mitochondrial (EC 2.3.1.-) (Lipoate biosynthesis protein) (Lipoate-protein ligase) (Lipoyl ligase)" Lipt1 Mus musculus (Mouse) 373 protein lipoylation [GO:0009249] GO:0005739; GO:0009249; GO:0016746 PATHWAY: Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2. 0 0 0 Q8WZ42 CHOYP_LOC575058.1.1 m.9533 sp TITIN_HUMAN 34.146 287 180 5 664 946 4849 5130 2.37E-35 150 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q99M80 CHOYP_PTPRT.45.45 m.63207 sp PTPRT_MOUSE 31.358 692 423 18 322 970 771 1453 2.37E-86 307 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN4 CHOYP_C1QL2.11.32 m.5932 sp C1QL3_MOUSE 29.565 115 76 2 213 326 143 253 2.37E-06 51.6 C1QL3_MOUSE reviewed Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) 255 regulation of synapse organization [GO:0050807] GO:0005576; GO:0005581; GO:0050807 0 0 0 PF00386;PF01391; Q9HB90 CHOYP_AAEL_AAEL005197.1.1 m.59507 sp RRAGC_HUMAN 71.951 328 86 3 38 362 59 383 2.37E-172 488 RRAGC_HUMAN reviewed Ras-related GTP-binding protein C (Rag C) (RagC) (GTPase-interacting protein 2) (TIB929) RRAGC Homo sapiens (Human) 399 "apoptotic process [GO:0006915]; cell cycle arrest [GO:0007050]; cell growth [GO:0016049]; cellular protein localization [GO:0034613]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; macroautophagy [GO:0016236]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of TORC1 signaling [GO:1903432]; regulation of TOR signaling [GO:0032006]; response to amino acid [GO:0043200]; RNA splicing [GO:0008380]; small GTPase mediated signal transduction [GO:0007264]; transcription, DNA-templated [GO:0006351]" GO:0000287; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005764; GO:0005829; GO:0006351; GO:0006915; GO:0007050; GO:0007264; GO:0008380; GO:0010506; GO:0016049; GO:0016236; GO:0019003; GO:0032006; GO:0032008; GO:0034198; GO:0034448; GO:0034613; GO:0043200; GO:0043231; GO:0046982; GO:0071230; GO:1903432; GO:1990131 0 0 0 PF04670; Q9HCU5 CHOYP_ZGC_92203.1.1 m.55468 sp PREB_HUMAN 38.596 399 220 12 4 388 1 388 2.37E-81 259 PREB_HUMAN reviewed Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12) PREB SEC12 Homo sapiens (Human) 417 "COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; IRE1-mediated unfolded protein response [GO:0036498]; protein exit from endoplasmic reticulum [GO:0032527]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000139; GO:0003677; GO:0005085; GO:0005090; GO:0005634; GO:0005789; GO:0006351; GO:0006355; GO:0006888; GO:0016020; GO:0030176; GO:0032527; GO:0036498; GO:0048208; GO:0070971 0 0 0 PF00400; Q9I925 CHOYP_FUCL7.1.1 m.20306 sp FUCL7_ANGJA 27.219 169 100 5 5 156 21 183 2.37E-07 51.6 FUCL7_ANGJA reviewed Fucolectin-7 0 Anguilla japonica (Japanese eel) 189 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9NQ86 CHOYP_LOC100373444.23.79 m.27899 sp TRI36_HUMAN 28.689 122 74 4 5 118 149 265 2.37E-07 55.8 TRI36_HUMAN reviewed E3 ubiquitin-protein ligase TRIM36 (EC 6.3.2.-) (RING finger protein 98) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) TRIM36 RBCC728 RNF98 Homo sapiens (Human) 728 acrosome reaction [GO:0007340]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726] GO:0000209; GO:0001669; GO:0004842; GO:0005829; GO:0005856; GO:0007340; GO:0008270; GO:0016874; GO:0051726; GO:0070062 0 0 0 PF00041;PF00643;PF13445; Q9R1R2 CHOYP_BRAFLDRAFT_82426.4.20 m.32669 sp TRIM3_MOUSE 24.354 271 178 12 300 555 486 744 2.37E-08 60.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UM73 CHOYP_ALK.1.2 m.9473 sp ALK_HUMAN 59.615 312 125 1 7 318 1088 1398 2.37E-128 409 ALK_HUMAN reviewed ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) ALK Homo sapiens (Human) 1620 activation of MAPK activity [GO:0000187]; cell proliferation [GO:0008283]; neuron development [GO:0048666]; phosphorylation [GO:0016310]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000187; GO:0004704; GO:0004713; GO:0004714; GO:0005524; GO:0005622; GO:0005887; GO:0007165; GO:0007169; GO:0008283; GO:0016310; GO:0042802; GO:0042981; GO:0043234; GO:0046777; GO:0048666; GO:0051092; GO:0070062 0 0 cd06263; PF00629;PF07714; Q9Y394 CHOYP_PHUM_PHUM490940.1.1 m.63934 sp DHRS7_HUMAN 48.986 296 148 3 27 320 29 323 2.37E-91 278 DHRS7_HUMAN reviewed Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) 339 0 GO:0016020; GO:0016491 0 0 0 PF00106; A0JM12 CHOYP_PTPRU.1.2 m.23417 sp MEG10_XENTR 36.744 215 109 12 159 369 347 538 2.38E-19 94 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AX52 CHOYP_CO6A5.6.6 m.56701 sp CO6A4_MOUSE 30.328 244 149 7 1 238 854 1082 2.38E-21 95.9 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A2VDZ3 CHOYP_MEF2C.1.1 m.35507 sp MEF2A_BOVIN 44.091 440 157 20 1 382 1 409 2.38E-81 262 MEF2A_BOVIN reviewed Myocyte-specific enhancer factor 2A MEF2A Bos taurus (Bovine) 492 apoptotic process [GO:0006915]; cardiac conduction [GO:0061337]; cellular response to calcium ion [GO:0071277]; dendrite morphogenesis [GO:0048813]; ERK5 cascade [GO:0070375]; MAPK cascade [GO:0000165]; mitochondrial genome maintenance [GO:0000002]; mitochondrion distribution [GO:0048311]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; ventricular cardiac myofibril assembly [GO:0055005] GO:0000002; GO:0000122; GO:0000165; GO:0000790; GO:0000977; GO:0000978; GO:0000981; GO:0001077; GO:0001105; GO:0003682; GO:0003705; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006915; GO:0033613; GO:0035035; GO:0042826; GO:0045944; GO:0046332; GO:0048311; GO:0048813; GO:0055005; GO:0061337; GO:0070375; GO:0071277 0 0 0 PF12347;PF00319; A3DH97 CHOYP_BRAFLDRAFT_81364.2.3 m.30348 sp RSGI6_CLOTH 31.2 375 240 7 177 545 375 737 2.38E-49 186 RSGI6_CLOTH reviewed "Anti-sigma-I factor RsgI6 (Endo-1,4-beta-xylanase) (EC 3.2.1.8)" rsgI6 Cthe_2119 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 760 xylan catabolic process [GO:0045493] GO:0005886; GO:0016021; GO:0031176; GO:0045493 PATHWAY: Glycan degradation; xylan degradation. {ECO:0000255|PROSITE-ProRule:PRU01096}. 0 0 PF00331;PF12791; A6NMZ7 CHOYP_SMP_159780.2.2 m.66794 sp CO6A6_HUMAN 27.473 182 118 4 959 1139 910 1078 2.38E-11 72.4 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; A7RNG8 CHOYP_LOC591283.1.1 m.46567 sp CCD22_NEMVE 52.286 503 229 6 5 499 140 639 2.38E-179 521 CCD22_NEMVE reviewed Coiled-coil domain-containing protein 22 homolog v1g180167 Nematostella vectensis (Starlet sea anemone) 644 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060] GO:0097602; GO:2000060 0 0 0 0 D3YXG0 CHOYP_LOC100161316.1.2 m.13604 sp HMCN1_MOUSE 25.615 488 275 20 59 483 2488 2950 2.38E-20 100 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E9Q784 CHOYP_LOC100568158.1.1 m.25977 sp ZC3HD_MOUSE 31.088 193 116 6 1426 1611 1546 1728 2.38E-21 105 ZC3HD_MOUSE reviewed Zinc finger CCCH domain-containing protein 13 Zc3h13 Mus musculus (Mouse) 1729 0 GO:0005654; GO:0016607; GO:0044822; GO:0046872 0 0 0 PF00642; O00214 CHOYP_BRAFLDRAFT_126856.3.3 m.58436 sp LEG8_HUMAN 39.416 137 77 2 63 199 185 315 2.38E-27 108 LEG8_HUMAN reviewed Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) LGALS8 Homo sapiens (Human) 317 xenophagy [GO:0098792] GO:0005615; GO:0005829; GO:0016020; GO:0030246; GO:0070062; GO:0098792 0 0 0 PF00337; O00370 CHOYP_LOC100537145.1.3 m.17301 sp LORF2_HUMAN 28.511 235 158 6 2 228 656 888 2.38E-19 92 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O15553 CHOYP_BRAFLDRAFT_88223.13.22 m.53285 sp MEFV_HUMAN 20.395 152 98 2 18 169 372 500 2.38E-06 53.9 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; O17320 CHOYP_LOC100533345.1.2 m.44847 sp ACT_CRAGI 90.323 62 6 0 44 105 1 62 2.38E-33 123 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O43736 CHOYP_LOC100357336.1.1 m.23582 sp ITM2A_HUMAN 29.06 234 115 10 35 266 35 219 2.38E-13 72 ITM2A_HUMAN reviewed Integral membrane protein 2A (Protein E25) ITM2A UNQ603/PRO1189 Homo sapiens (Human) 263 negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399] GO:0001540; GO:0005794; GO:0005886; GO:0007399; GO:0016021; GO:0042985; GO:0070062 0 0 0 PF04089; P50482 CHOYP_LOC100898717.1.3 m.25016 sp SL9A2_RABIT 35.085 761 436 18 53 795 73 793 2.38E-128 406 SL9A2_RABIT reviewed Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) SLC9A2 NHE2 Oryctolagus cuniculus (Rabbit) 809 regulation of pH [GO:0006885] GO:0006885; GO:0015385; GO:0016021 0 0 0 PF00999;PF16644; P56377 CHOYP_LOC659702.1.1 m.7231 sp AP1S2_HUMAN 83.439 157 26 0 2 158 1 157 2.38E-94 273 AP1S2_HUMAN reviewed AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) AP1S2 DC22 Homo sapiens (Human) 157 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular protein transport [GO:0006886]; regulation of defense response to virus by virus [GO:0050690]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0005765; GO:0005794; GO:0005829; GO:0005905; GO:0006886; GO:0008565; GO:0016192; GO:0019886; GO:0030119; GO:0030659; GO:0030669; GO:0032588; GO:0043231; GO:0050690 0 0 0 PF01217; P61799 CHOYP_LOC592796.2.2 m.63824 sp APTX_DANRE 61.392 158 54 4 28 181 146 300 2.38E-61 197 APTX_DANRE reviewed Aprataxin (EC 3.-.-.-) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) aptx Danio rerio (Zebrafish) (Brachydanio rerio) 324 DNA repair [GO:0006281] GO:0003677; GO:0005654; GO:0005730; GO:0006281; GO:0033699; GO:0046872 0 0 0 PF16278; P71359 CHOYP_LOC100370129.1.4 m.6950 sp RECQ_HAEIN 28.14 430 243 13 7 407 14 406 2.38E-41 157 RECQ_HAEIN reviewed ATP-dependent DNA helicase RecQ (EC 3.6.4.12) recQ HI_0728 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 619 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; SOS response [GO:0009432] GO:0003677; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0009378; GO:0009432; GO:0043140; GO:0043590 0 0 0 PF00270;PF00271;PF00570;PF16124;PF09382; P77735 CHOYP_LOC100366708.1.1 m.19335 sp YAJO_ECOLI 31.818 308 188 7 3 300 6 301 2.38E-39 145 YAJO_ECOLI reviewed Uncharacterized oxidoreductase YajO (EC 1.-.-.-) yajO b0419 JW0409 Escherichia coli (strain K12) 324 thiamine metabolic process [GO:0006772] GO:0005829; GO:0006772; GO:0016491 0 0 cd06660; PF00248; Q03249 CHOYP_LOC100693867.1.1 m.27278 sp GALT_MOUSE 63.768 345 125 0 2 346 22 366 2.38E-170 482 GALT_MOUSE reviewed Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (EC 2.7.7.12) (UDP-glucose--hexose-1-phosphate uridylyltransferase) Galt Mus musculus (Mouse) 379 galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623] GO:0005794; GO:0006012; GO:0008108; GO:0008270; GO:0033499; GO:0061623 PATHWAY: Carbohydrate metabolism; galactose metabolism. 0 0 PF02744;PF01087; Q05695 CHOYP_LOC101160163.2.2 m.44944 sp L1CAM_RAT 23.347 484 314 20 39 501 48 495 2.38E-21 103 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q0VC74 CHOYP_TMLH.1.1 m.46297 sp TMLH_BOVIN 45.232 367 193 4 92 452 56 420 2.38E-119 358 TMLH_BOVIN reviewed "Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD)" TMLHE Bos taurus (Bovine) 421 carnitine biosynthetic process [GO:0045329] GO:0005506; GO:0005759; GO:0031418; GO:0045329; GO:0050353 PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis. 0 0 PF06155;PF02668; Q10901 CHOYP_LOC101170755.1.1 m.1878 sp EAA1_CAEEL 32.851 484 316 2 4 479 8 490 2.38E-95 300 EAA1_CAEEL reviewed Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) glt-1 C12D12.2 Caenorhabditis elegans 503 0 GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0042995 0 0 0 PF00375; Q13310 CHOYP_LOC100370010.3.5 m.19118 sp PABP4_HUMAN 48.649 74 24 3 2 66 401 469 2.38E-10 61.2 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q32PA9 CHOYP_LOC100563952.1.1 m.30232 sp FKBP2_BOVIN 70.345 145 38 3 1 145 1 140 2.38E-64 196 FKBP2_BOVIN reviewed Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (FK506-binding protein 2) (FKBP-2) (Rotamase) FKBP2 Bos taurus (Bovine) 140 chaperone-mediated protein folding [GO:0061077] GO:0003755; GO:0005528; GO:0005789; GO:0061077 0 0 0 PF00254; Q3UWZ0 CHOYP_BRCA1.1.1 m.19169 sp TRI75_MOUSE 28.788 132 93 1 38 169 4 134 2.38E-12 67.8 TRI75_MOUSE reviewed Tripartite motif-containing protein 75 Trim75 Gm794 Mus musculus (Mouse) 467 0 GO:0005622; GO:0008270 0 0 0 PF13765;PF00622;PF00643; Q5ND28 CHOYP_contig_018632 m.21869 sp SREC_MOUSE 33.143 175 96 8 100 262 176 341 2.38E-14 77.8 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q60596 CHOYP_LOC591797.1.3 m.11526 sp XRCC1_MOUSE 41.529 667 310 22 1 624 1 630 2.38E-148 446 XRCC1_MOUSE reviewed DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) Xrcc1 Xrcc-1 Mus musculus (Mouse) 631 base-excision repair [GO:0006284]; DNA repair [GO:0006281]; hippocampus development [GO:0021766]; single strand break repair [GO:0000012] GO:0000012; GO:0003684; GO:0005634; GO:0006281; GO:0006284; GO:0019899; GO:0021766 0 0 0 PF00533;PF16589;PF01834; Q68ED3 CHOYP_PAPD5.1.1 m.58103 sp PAPD5_MOUSE 56.154 130 49 4 3 126 319 446 2.38E-37 137 PAPD5_MOUSE reviewed Non-canonical poly(A) RNA polymerase PAPD5 (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2) Papd5 Mus musculus (Mouse) 633 cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; mitotic nuclear division [GO:0007067]; mRNA processing [GO:0006397]; rRNA processing [GO:0006364] GO:0003677; GO:0003887; GO:0004652; GO:0005730; GO:0005737; GO:0006364; GO:0006397; GO:0007067; GO:0044822; GO:0046872; GO:0051301; GO:0071044 0 0 0 PF01909;PF03828; Q6H236 CHOYP_LOC101426183.1.1 m.53924 sp PEG3_BOVIN 42.994 314 142 19 278 558 1254 1563 2.38E-16 86.7 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6NS09 CHOYP_TM45B.1.1 m.56566 sp TM45B_XENLA 37.143 245 133 5 1 235 1 234 2.38E-45 157 TM45B_XENLA reviewed Transmembrane protein 45B tmem45b Xenopus laevis (African clawed frog) 280 0 GO:0016021 0 0 0 PF04819; Q6PFY8 CHOYP_TRI45.23.23 m.64012 sp TRI45_MOUSE 28.634 227 142 5 19 233 103 321 2.38E-14 76.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7G0 CHOYP_ABHV_ORF102.1.1 m.51670 sp Y068_OSHVF 20.67 537 354 9 155 625 13 543 2.38E-27 120 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6XIM8 CHOYP_PP1A.1.1 m.25949 sp RS15A_DROYA 83.486 109 18 0 21 129 1 109 2.38E-62 201 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q70LM4 CHOYP_CHRO_3730.1.1 m.28464 sp LGRD_BREPA 28.354 1051 646 30 54 1078 4044 5013 2.38E-97 345 LGRD_BREPA reviewed Linear gramicidin synthase subunit D [Includes: ATP-dependent D-leucine adenylase (D-LeuA) (D-leucine activase); Leucine racemase [ATP-hydrolyzing] (EC 5.1.1.-); ATP-dependent tryptophan adenylase (TrpA) (Tryptophan activase); ATP-dependent glycine adenylase (GlyA) (Glycine activase); Linear gramicidin--PCP reductase (EC 1.-.-.-)] lgrD Brevibacillus parabrevis 5085 antibiotic biosynthetic process [GO:0017000] GO:0016491; GO:0016853; GO:0016874; GO:0017000; GO:0031177 0 0 cd05235; PF00501;PF13193;PF00668;PF07993;PF00550; Q86V25 CHOYP_VASH1.1.1 m.47048 sp VASH2_HUMAN 48.529 340 163 4 34 372 27 355 2.38E-111 332 VASH2_HUMAN reviewed Vasohibin-2 (Vasohibin-like protein) VASH2 VASHL Homo sapiens (Human) 355 positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938] GO:0001938; GO:0005576; GO:0005737; GO:0045766 0 0 0 PF14822; Q89YT0 CHOYP_TRIADDRAFT_21078.2.2 m.64279 sp END4_BACTN 51.613 279 131 2 463 741 2 276 2.38E-102 318 END4_BACTN reviewed Probable endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV) nfo BT_4651 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) 277 base-excision repair [GO:0006284] GO:0003677; GO:0003906; GO:0006284; GO:0008081; GO:0008270; GO:0008833 0 0 0 PF01261; Q8C8H8 CHOYP_KY.2.5 m.10560 sp KY_MOUSE 22.892 415 269 11 36 416 157 554 2.38E-20 97.1 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8SPK0 CHOYP_BRAFLDRAFT_58592.1.2 m.1729 sp CP4AP_PIG 36.534 479 286 6 26 497 35 502 2.38E-106 329 CP4AP_PIG reviewed Cytochrome P450 4A25 (CYPIVA25) (Fatty acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.13.205) CYP4A25 Sus scrofa (Pig) 504 0 GO:0004497; GO:0005506; GO:0005789; GO:0016021; GO:0016705; GO:0020037 0 0 0 PF00067; Q91W63 CHOYP_LOC100895171.1.1 m.11811 sp NRK1_MOUSE 38.83 188 108 5 7 191 4 187 2.38E-39 136 NRK1_MOUSE reviewed Nicotinamide riboside kinase 1 (NRK 1) (NmR-K 1) (EC 2.7.1.22) (Nicotinic acid riboside kinase 1) (EC 2.7.1.173) (Ribosylnicotinamide kinase 1) (RNK 1) (Ribosylnicotinic acid kinase 1) Nmrk1 Nrk1 Mus musculus (Mouse) 195 NAD biosynthetic process [GO:0009435] GO:0005524; GO:0009435; GO:0046872; GO:0050262 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis. {ECO:0000250|UniProtKB:Q9NWW6}. 0 0 0 Q969H0 CHOYP_BRAFLDRAFT_93676.1.1 m.17032 sp FBXW7_HUMAN 29.841 315 205 6 65 373 347 651 2.38E-42 160 FBXW7_HUMAN reviewed F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) 707 cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; lipid homeostasis [GO:0055088]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1903146]; regulation of protein localization [GO:0032880]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; vasculature development [GO:0001944]; viral process [GO:0016032] GO:0000209; GO:0001944; GO:0004842; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006974; GO:0007062; GO:0010868; GO:0010883; GO:0016032; GO:0016567; GO:0019005; GO:0030332; GO:0030674; GO:0031146; GO:0031398; GO:0031625; GO:0032876; GO:0032880; GO:0034644; GO:0042802; GO:0043234; GO:0045741; GO:0045746; GO:0050816; GO:0050821; GO:0051443; GO:0055088; GO:0070374; GO:0097027; GO:1901800; GO:1902806; GO:1903146; GO:1903378; GO:1903955; GO:1990452; GO:2000060; GO:2000346; GO:2000639 0 0 0 PF12937;PF00400; Q96IG2 CHOYP_BRAFLDRAFT_67760.1.1 m.48015 sp FXL20_HUMAN 30.508 236 153 4 196 426 144 373 2.38E-25 112 FXL20_HUMAN reviewed F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) FBXL20 FBL2 Homo sapiens (Human) 436 behavioral fear response [GO:0001662] GO:0001662; GO:0005737 0 0 0 PF12937;PF13516; Q9BYV9 CHOYP_LOC100167826.1.2 m.13080 sp BACH2_HUMAN 26.718 131 88 4 6 131 13 140 2.38E-07 58.2 BACH2_HUMAN reviewed Transcription regulator protein BACH2 (BTB and CNC homolog 2) BACH2 Homo sapiens (Human) 841 protein ubiquitination [GO:0016567]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000980; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006366; GO:0016567; GO:0031463 0 0 0 PF00651;PF03131; Q9GNE2 CHOYP_DMOJ_GI20545.1.1 m.61051 sp RL23_AEDAE 90.385 104 10 0 30 133 1 104 2.38E-63 192 RL23_AEDAE reviewed 60S ribosomal protein L23 (AeRpL17A) (L17A) RpL23-A RpL17A AAEL013097; RpL23-B AAEL013583; RpL23-C AAEL015006 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 140 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00238; Q9JLC8 CHOYP_SACS.12.17 m.53659 sp SACS_MOUSE 29.845 965 566 32 31 924 90 1014 2.38E-99 346 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9MBF8 CHOYP_LOC100376274.6.7 m.47649 sp DYH1B_CHLRE 26.418 670 445 13 633 1284 2818 3457 2.38E-63 245 DYH1B_CHLRE reviewed "Dynein-1-beta heavy chain, flagellar inner arm I1 complex (1-beta DHC) (Dynein-1, subspecies f)" DHC10 IDA2 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4513 cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005930; GO:0008017; GO:0016887; GO:0031514; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q9UJT9 CHOYP_FBXL7.1.3 m.11518 sp FBXL7_HUMAN 54.762 378 170 1 252 628 114 491 2.38E-153 454 FBXL7_HUMAN reviewed F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) 491 cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000086; GO:0000151; GO:0004842; GO:0005737; GO:0005813; GO:0006511; GO:0007067; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q9ULJ7 CHOYP_LOC581927.18.27 m.46536 sp ANR50_HUMAN 31.979 566 330 17 591 1105 552 1113 2.38E-52 204 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VFK6 CHOYP_LOC101237965.4.4 m.65256 sp KMT5A_DROME 40.476 126 67 4 57 177 555 677 2.38E-16 79.7 KMT5A_DROME reviewed Histone-lysine N-methyltransferase pr-set7 (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (dSET8) pr-set7 KMT5A CG3307 Drosophila melanogaster (Fruit fly) 691 "cell division [GO:0051301]; chromosome condensation [GO:0030261]; DNA damage checkpoint [GO:0000077]; histone H4-K20 monomethylation [GO:0034771]; histone methylation [GO:0016571]; mitotic nuclear division [GO:0007067]; negative regulation of histone acetylation [GO:0035067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000077; GO:0005634; GO:0005700; GO:0006351; GO:0006355; GO:0007067; GO:0016571; GO:0030261; GO:0034771; GO:0035067; GO:0042799; GO:0051301 0 0 0 PF00856; Q9W5U2 CHOYP_LOC580404.1.3 m.7047 sp CHIT3_DROME 26.556 241 134 9 3 212 560 788 2.38E-12 68.9 CHIT3_DROME reviewed Probable chitinase 3 (EC 3.2.1.14) (Probable chitinase 1) Cht3 Cht1 CG18140 Drosophila melanogaster (Fruit fly) 2286 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0006032; GO:0008061 0 0 0 PF01607;PF00704; Q9WTP6 CHOYP_BRAFLDRAFT_115743.1.1 m.61177 sp KAD2_MOUSE 69.863 219 66 0 17 235 10 228 2.38E-117 338 KAD2_MOUSE reviewed "Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]" Ak2 Mus musculus (Mouse) 239 ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; brain development [GO:0007420]; dATP metabolic process [GO:0046060]; liver development [GO:0001889]; oxidative phosphorylation [GO:0006119]; response to thyroid hormone [GO:0097066] GO:0001889; GO:0004017; GO:0005524; GO:0005739; GO:0005743; GO:0005758; GO:0005829; GO:0006119; GO:0006172; GO:0007420; GO:0036126; GO:0046033; GO:0046060; GO:0070062; GO:0097066; GO:0097226 0 0 cd01428; PF05191; Q9WV92 CHOYP_E41L1.1.1 m.40410 sp E41L3_MOUSE 57.925 347 140 4 61 406 113 454 2.38E-133 436 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; A1L2Y1 CHOYP_UCP2.3.3 m.14562 sp FSIP1_XENLA 33.775 302 159 10 166 454 159 432 2.39E-25 113 FSIP1_XENLA reviewed Fibrous sheath-interacting protein 1 fsip1 Xenopus laevis (African clawed frog) 459 0 0 0 0 0 PF15554; E1C2Z0 CHOYP_MMS22.1.1 m.15823 sp MMS22_CHICK 25.458 1037 657 28 185 1130 217 1228 2.39E-88 314 MMS22_CHICK reviewed Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like) MMS22L Gallus gallus (Chicken) 1243 double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297] GO:0000724; GO:0031297; GO:0043596 0 0 0 PF14911;PF14910; E7EYQ9 CHOYP_LOC591901.3.3 m.48421 sp TM216_DANRE 43.262 141 79 1 6 146 21 160 2.39E-31 112 TM216_DANRE reviewed Transmembrane protein 216 tmem216 Danio rerio (Zebrafish) (Brachydanio rerio) 160 cilium assembly [GO:0042384] GO:0005737; GO:0005856; GO:0016021; GO:0042384; GO:0042995 0 0 0 PF09799; O01761 CHOYP_TITIN.9.19 m.36452 sp UNC89_CAEEL 24.697 413 275 16 187 586 4296 4685 2.39E-10 69.3 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O14975 CHOYP_BRAFLDRAFT_102226.1.1 m.48829 sp S27A2_HUMAN 39.735 604 346 10 27 625 27 617 2.39E-145 437 S27A2_HUMAN reviewed "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) 620 bile acid biosynthetic process [GO:0006699]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; very long-chain fatty acid catabolic process [GO:0042760] GO:0001561; GO:0001676; GO:0004467; GO:0005102; GO:0005524; GO:0005739; GO:0005778; GO:0005779; GO:0005788; GO:0005789; GO:0006635; GO:0006699; GO:0015245; GO:0019899; GO:0030176; GO:0031957; GO:0042760; GO:0044539; GO:0050197; GO:0070062; GO:0070251; GO:0097089; GO:0102391 0 0 0 PF00501;PF13193; O75096 CHOYP_LRP4.1.5 m.274 sp LRP4_HUMAN 26.036 941 602 36 68 973 482 1363 2.39E-60 233 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; O75179 CHOYP_LOC753709.2.44 m.3328 sp ANR17_HUMAN 34.772 394 211 12 10 359 298 689 2.39E-44 167 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O95236 CHOYP_LOC101161888.1.1 m.45908 sp APOL3_HUMAN 22.383 277 177 9 41 311 149 393 2.39E-06 52.4 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P04352 CHOYP_CALM.25.50 m.33713 sp CALM_CHLRE 63.265 147 54 0 2 148 6 152 2.39E-67 204 CALM_CHLRE reviewed Calmodulin (CaM) 0 Chlamydomonas reinhardtii (Chlamydomonas smithii) 163 0 GO:0005509 0 0 0 PF13499; P04755 CHOYP_LOC100533245.3.6 m.31983 sp ACH3_DROME 48.179 357 169 6 1 349 168 516 2.39E-91 286 ACH3_DROME reviewed Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) nAChRbeta1 Acr64B AcrD ard nAcRbeta-64B CG11348 Drosophila melanogaster (Fruit fly) 521 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P08472 CHOYP_BRAFLDRAFT_91441.1.1 m.47971 sp M130_STRPU 29.111 371 203 13 220 563 400 737 2.39E-26 117 M130_STRPU reviewed Mesenchyme-specific cell surface glycoprotein (MSP130) 0 Strongylocentrotus purpuratus (Purple sea urchin) 779 0 GO:0005886; GO:0031225 0 0 0 0 P16330 CHOYP_SMP_147600.1.1 m.18072 sp CN37_MOUSE 29.243 383 238 12 89 458 30 392 2.39E-42 158 CN37_MOUSE reviewed "2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)" Cnp Cnp1 Mus musculus (Mouse) 420 adult locomotory behavior [GO:0008344]; aging [GO:0007568]; axonogenesis [GO:0007409]; cyclic nucleotide catabolic process [GO:0009214]; forebrain development [GO:0030900]; microtubule cytoskeleton organization [GO:0000226]; oligodendrocyte differentiation [GO:0048709]; regulation of mitochondrial membrane permeability [GO:0046902]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; substantia nigra development [GO:0021762] GO:0000226; GO:0003723; GO:0004113; GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005741; GO:0005743; GO:0005874; GO:0005886; GO:0005902; GO:0007409; GO:0007568; GO:0008344; GO:0009214; GO:0009636; GO:0016020; GO:0021762; GO:0030551; GO:0030900; GO:0031143; GO:0032496; GO:0035748; GO:0035749; GO:0042470; GO:0043209; GO:0046902; GO:0048471; GO:0048709; GO:0070062 0 0 0 PF05881; P41996 CHOYP_BRAFLDRAFT_125880.1.3 m.7081 sp CPG2_CAEEL 30.172 116 78 2 17 130 243 357 2.39E-06 48.9 CPG2_CAEEL reviewed Chondroitin proteoglycan-2 (Cytokinesis protein B0280.5) cpg-2 B0280.5 Caenorhabditis elegans 524 chitin metabolic process [GO:0006030]; eggshell formation [GO:0030703]; embryo development [GO:0009790]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465] GO:0000281; GO:0005576; GO:0006030; GO:0008061; GO:0009790; GO:0030703; GO:0032465 0 0 0 PF01607; P50882 CHOYP_RL9.5.6 m.63453 sp RL9_DROME 71.505 186 52 1 18 202 1 186 2.39E-93 273 RL9_DROME reviewed 60S ribosomal protein L9 RpL9 M(2)32D CG6141 Drosophila melanogaster (Fruit fly) 190 centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052] GO:0000022; GO:0002181; GO:0003723; GO:0003735; GO:0005840; GO:0007052; GO:0019843; GO:0022625; GO:0051298 0 0 0 PF00347; P55866 CHOYP_CASP10.3.7 m.34986 sp CASP3_XENLA 30.968 155 95 6 215 357 40 194 2.39E-11 67.8 CASP3_XENLA reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (xCPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] casp3 Xenopus laevis (African clawed frog) 282 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q19673 CHOYP_CBR-TYR-2.1.2 m.10859 sp TYR3_CAEEL 37.134 307 160 10 212 497 107 401 2.39E-55 206 TYR3_CAEEL reviewed Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans 693 0 GO:0004497; GO:0046872 0 0 0 PF01549;PF00264; Q1JP73 CHOYP_CI064.1.1 m.9517 sp CI064_BOVIN 54.412 340 154 1 7 346 3 341 2.39E-136 394 CI064_BOVIN reviewed UPF0553 protein C9orf64 homolog 0 Bos taurus (Bovine) 341 0 0 0 0 0 PF10343; Q3UMR0 CHOYP_LOC590633.1.1 m.32259 sp ANR27_MOUSE 25.815 399 253 12 28 420 6 367 2.39E-20 99 ANR27_MOUSE reviewed Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein) (VPS9-ankyrin-repeat protein) Ankrd27 Varp Mus musculus (Mouse) 1048 "early endosome to late endosome transport [GO:0045022]; endosome to melanosome transport [GO:0035646]; negative regulation of SNARE complex assembly [GO:0035544]; neuron projection morphogenesis [GO:0048812]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0000149; GO:0005085; GO:0005096; GO:0005737; GO:0005764; GO:0005769; GO:0005770; GO:0005829; GO:0005886; GO:0015031; GO:0016020; GO:0017137; GO:0030133; GO:0030659; GO:0035544; GO:0035646; GO:0042470; GO:0043005; GO:0043547; GO:0045022; GO:0048812; GO:0050775; GO:0097422; GO:1990126 0 0 0 PF00023;PF12796;PF02204; Q4R544 CHOYP_TVAG_423260.1.1 m.31704 sp ASB8_MACFA 34.167 120 77 2 335 454 57 174 2.39E-10 64.7 ASB8_MACFA reviewed Ankyrin repeat and SOCS box protein 8 (ASB-8) ASB8 QccE-19709 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 288 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005737; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q502K3 CHOYP_AASI_0703.2.2 m.61393 sp ANR52_DANRE 33.775 302 176 6 730 1023 22 307 2.39E-34 146 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q502M6 CHOYP_AFUA_1G01020.32.50 m.42722 sp ANR29_DANRE 38.095 168 104 0 1 168 45 212 2.39E-32 120 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q56YT0 CHOYP_LOC100198324.1.6 m.5952 sp LAC3_ARATH 25.849 383 192 11 30 375 239 566 2.39E-18 90.5 LAC3_ARATH reviewed Laccase-3 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 3) (Diphenol oxidase 3) (Urishiol oxidase 3) LAC3 At2g30210 T9D9.2 Arabidopsis thaliana (Mouse-ear cress) 570 lignin catabolic process [GO:0046274] GO:0005507; GO:0016722; GO:0046274; GO:0048046; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q5G267 CHOYP_BRAFLDRAFT_68915.5.7 m.20063 sp NETR_MACMU 43.467 375 194 6 12 373 226 595 2.39E-96 308 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5G268 CHOYP_LOC373214.1.1 m.21876 sp NETR_NOMLE 47.418 213 108 3 645 857 279 487 2.39E-49 194 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5YCC5 CHOYP_BRAFLDRAFT_199751.2.2 m.41403 sp TMC7_CHICK 29.014 710 451 17 124 817 40 712 2.39E-90 303 TMC7_CHICK reviewed Transmembrane channel-like protein 7 Tmc7 Gallus gallus (Chicken) 735 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q6AYD3 CHOYP_LOC100370552.1.2 m.25477 sp PA2G4_RAT 63.67 267 96 1 496 761 98 364 2.39E-116 360 PA2G4_RAT reviewed Proliferation-associated protein 2G4 Pa2g4 Rattus norvegicus (Rat) 394 "negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005654; GO:0005730; GO:0005737; GO:0006351; GO:0006364; GO:0006417; GO:0016020; GO:0030529; GO:0043066; GO:0044822; GO:0045597; GO:0045892; GO:0070062 0 0 0 PF00557; Q6DGV7 CHOYP_BRAFLDRAFT_206123.2.2 m.11479 sp M17L2_DANRE 42.778 180 96 3 1 179 13 186 2.39E-44 148 M17L2_DANRE reviewed Mpv17-like protein 2 mpv17l2 zgc:92754 Danio rerio (Zebrafish) (Brachydanio rerio) 199 0 GO:0005743; GO:0016021 0 0 0 PF04117; Q6P8C8 CHOYP_ARL8A.1.1 m.12151 sp ARL8A_XENTR 90.811 185 17 0 39 223 1 185 2.39E-126 357 ARL8A_XENTR reviewed ADP-ribosylation factor-like protein 8A (ADP-ribosylation factor-like protein 10B) arl8a arl10b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 186 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005765; GO:0007059; GO:0007067; GO:0007264; GO:0031902; GO:0051301 0 0 0 PF00025; Q6ZRF8 CHOYP_LOC100888740.2.2 m.39560 sp RN207_HUMAN 23.176 233 158 8 36 257 111 333 2.39E-07 56.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q866E7 CHOYP_FUT2.3.5 m.34163 sp FUT1_AOTNA 28.689 366 214 12 18 358 10 353 2.39E-36 138 FUT1_AOTNA reviewed "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Aotus nancymaae (Ma's night monkey) 366 protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q8BLY1 CHOYP_LOC100374767.3.3 m.12933 sp SMOC1_MOUSE 30.847 295 164 7 307 572 175 458 2.39E-32 133 SMOC1_MOUSE reviewed SPARC-related modular calcium-binding protein 1 (SPARC-related gene protein) (Secreted modular calcium-binding protein 1) (SMOC-1) Smoc1 Srg Mus musculus (Mouse) 463 cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; eye development [GO:0001654]; limb development [GO:0060173]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of osteoblast differentiation [GO:0045667]; signal transduction [GO:0007165] GO:0001654; GO:0005509; GO:0005604; GO:0007165; GO:0010811; GO:0030154; GO:0030198; GO:0045667; GO:0050840; GO:0060173 0 0 0 PF07648;PF10591;PF00086; Q8CIW6 CHOYP_LOC101171246.1.1 m.31539 sp S26A6_MOUSE 33.63 562 346 8 14 569 22 562 2.39E-97 317 S26A6_MOUSE reviewed Solute carrier family 26 member 6 (Anion exchange transporter) (Chloride-formate exchanger) (Pendrin-L1) (Pendrin-like protein 1) (Putative anion transporter-1) (Pat-1) Slc26a6 Cfex Pat1 Mus musculus (Mouse) 758 angiotensin-activated signaling pathway [GO:0038166]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to fructose stimulus [GO:0071332]; cellular response to interferon-gamma [GO:0071346]; chloride transport [GO:0006821]; epithelial fluid transport [GO:0042045]; formate transport [GO:0015724]; intestinal absorption [GO:0050892]; intracellular pH elevation [GO:0051454]; mannitol transport [GO:0015797]; oxalate transport [GO:0019532]; oxalic acid secretion [GO:0046724]; positive regulation of dipeptide transmembrane transport [GO:2001150]; protein kinase C signaling [GO:0070528]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]; sulfate transport [GO:0008272]; transepithelial chloride transport [GO:0030321]; transepithelial transport [GO:0070633] GO:0005254; GO:0005622; GO:0005783; GO:0005886; GO:0005887; GO:0006821; GO:0008271; GO:0008272; GO:0012506; GO:0015106; GO:0015108; GO:0015116; GO:0015301; GO:0015499; GO:0015562; GO:0015659; GO:0015660; GO:0015701; GO:0015724; GO:0015797; GO:0016020; GO:0016021; GO:0016323; GO:0016324; GO:0019531; GO:0019532; GO:0030165; GO:0030321; GO:0030659; GO:0031526; GO:0031988; GO:0034707; GO:0038166; GO:0042045; GO:0042391; GO:0046724; GO:0048240; GO:0050892; GO:0051453; GO:0051454; GO:0070528; GO:0070633; GO:0071320; GO:0071332; GO:0071346; GO:0097225; GO:2001150 0 0 0 PF01740;PF00916; Q8JFQ4 CHOYP_NEMVEDRAFT_V1G244307.1.1 m.17681 sp RDM1_CHICK 31.399 293 162 10 10 283 3 275 2.39E-31 121 RDM1_CHICK reviewed RAD52 motif-containing protein 1 RDM1 Gallus gallus (Chicken) 277 DNA recombination [GO:0006310]; DNA repair [GO:0006281] GO:0000166; GO:0003677; GO:0003723; GO:0005730; GO:0005737; GO:0006281; GO:0006310 0 0 0 PF04098;PF00076; Q8R5G2 CHOYP_MUTYH.1.1 m.16534 sp MUTYH_RAT 50.862 464 204 7 19 468 51 504 2.39E-157 459 MUTYH_RAT reviewed Adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (rMYH) Mutyh Myh Rattus norvegicus (Rat) 516 base-excision repair [GO:0006284]; response to oxidative stress [GO:0006979] GO:0003677; GO:0005634; GO:0005739; GO:0006284; GO:0006979; GO:0019104; GO:0046872; GO:0051539 0 0 cd03431;cd00056; PF00633;PF00730;PF14815; Q8TCB0 CHOYP_BRAFLDRAFT_99019.4.8 m.33371 sp IFI44_HUMAN 26.621 293 177 11 23 312 24 281 2.39E-23 102 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q96AB6 CHOYP_RSSA.10.10 m.65717 sp NTAN1_HUMAN 39.286 308 185 2 1 308 1 306 2.39E-81 251 NTAN1_HUMAN reviewed Protein N-terminal asparagine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal asparagine amidohydrolase) (PNAA) (Protein NH2-terminal asparagine deamidase) (PNAD) (Protein N-terminal Asn amidase) (Protein N-terminal asparagine amidase) (Protein NTN-amidase) NTAN1 Homo sapiens (Human) 310 adult locomotory behavior [GO:0008344]; memory [GO:0007613] GO:0005634; GO:0005737; GO:0007613; GO:0008344; GO:0008418 0 0 0 PF14736; Q96BD5 CHOYP_PHF21A.1.1 m.27494 sp PF21A_HUMAN 39.931 288 138 7 191 447 344 627 2.39E-59 209 PF21A_HUMAN reviewed PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) PHF21A BHC80 KIAA1696 BM-006 Homo sapiens (Human) 680 "blood coagulation [GO:0007596]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000122; GO:0000977; GO:0003682; GO:0003712; GO:0004407; GO:0005654; GO:0006351; GO:0006355; GO:0007596; GO:0008270; GO:0042393; GO:1990391 0 0 0 PF00628; Q9BRZ2 CHOYP_LOC100376608.1.4 m.31518 sp TRI56_HUMAN 35.931 231 135 4 3 225 9 234 2.39E-41 152 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9CYB0 CHOYP_ROA3.2.2 m.11067 sp TRI13_MOUSE 22.491 289 184 8 6 278 1 265 2.39E-15 82 TRI13_MOUSE reviewed E3 ubiquitin-protein ligase TRIM13 (EC 6.3.2.-) (Putative tumor suppressor RFP2) (Ret finger protein 2) (Tripartite motif-containing protein 13) Trim13 Rfp2 Mus musculus (Mouse) 407 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; innate immune response [GO:0045087]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell death [GO:0010942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; response to gamma radiation [GO:0010332] GO:0004842; GO:0004871; GO:0005737; GO:0005789; GO:0008270; GO:0010332; GO:0010942; GO:0016021; GO:0016239; GO:0016874; GO:0030433; GO:0032897; GO:0043123; GO:0043161; GO:0045087; GO:0051092; GO:0051865; GO:0097038; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q9D7K2 CHOYP_TEN1L.1.1 m.18251 sp TEN1L_MOUSE 35.772 123 73 3 3 120 2 123 2.39E-17 76.3 TEN1L_MOUSE reviewed CST complex subunit TEN1 (Protein telomeric pathways with STN1 homolog) (Telomere length regulation protein TEN1 homolog) Ten1 Mus musculus (Mouse) 161 negative regulation of telomerase activity [GO:0051974]; regulation of telomere maintenance via telomere lengthening [GO:1904356] GO:0000784; GO:0003697; GO:0005634; GO:0010521; GO:0042162; GO:0051974; GO:1904356; GO:1990879 0 0 0 PF15490; Q9JLV6 CHOYP_LOC100707367.1.1 m.16292 sp PNKP_MOUSE 54.011 374 170 2 272 643 146 519 2.39E-150 448 PNKP_MOUSE reviewed Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] Pnkp Mus musculus (Mouse) 522 "dephosphorylation [GO:0016311]; DNA 3' dephosphorylation involved in DNA repair [GO:0098504]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; nucleotide phosphorylation [GO:0046939]; polynucleotide 3' dephosphorylation [GO:0098506]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; response to oxidative stress [GO:0006979]" GO:0003690; GO:0005524; GO:0005634; GO:0005730; GO:0006281; GO:0006979; GO:0016020; GO:0016311; GO:0019201; GO:0032212; GO:0042769; GO:0046403; GO:0046404; GO:0046939; GO:0051973; GO:0098504; GO:0098506; GO:1904355 0 0 0 PF08645; Q9NZM3 CHOYP_ITSN1.2.4 m.5898 sp ITSN2_HUMAN 42.662 293 119 7 3 259 762 1041 2.39E-62 219 ITSN2_HUMAN reviewed Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein) ITSN2 KIAA1256 SH3D1B SWAP Homo sapiens (Human) 1697 endocytosis [GO:0006897]; positive regulation of dendrite extension [GO:1903861]; regulation of Rho protein signal transduction [GO:0035023] GO:0005070; GO:0005089; GO:0005509; GO:0005737; GO:0005813; GO:0006897; GO:0035023; GO:0070062; GO:1903861 0 0 0 PF00168;PF12763;PF16652;PF00621;PF00018;PF07653;PF14604; Q9U641 CHOYP_BRAFLDRAFT_127853.1.1 m.26753 sp CMFB_DICDI 50.82 427 197 5 51 466 81 505 2.39E-137 407 CMFB_DICDI reviewed Conditioned medium factor receptor 1 cmfB cmfr1 DDB_G0289157 Dictyostelium discoideum (Slime mold) 510 0 GO:0016021; GO:0016491; GO:0071949 0 0 0 PF01494; Q9VCA2 CHOYP_ORCT.1.6 m.27926 sp ORCT_DROME 44.465 533 276 5 1 529 1 517 2.39E-145 433 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9VR59 CHOYP_LOC100863008.1.2 m.12164 sp VIP1_DROME 56.333 300 131 0 1 300 630 929 2.39E-109 369 VIP1_DROME reviewed Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.21) (EC 2.7.4.24) (InsP6 and PP-IP5 kinase) l(1)G0196 CG14616 Drosophila melanogaster (Fruit fly) 1696 inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958] GO:0000827; GO:0000828; GO:0000829; GO:0000832; GO:0005524; GO:0005829; GO:0006020; GO:0032958; GO:0033857; GO:0052723; GO:0052724 0 0 cd07061; PF00328; Q9WTQ7 CHOYP_LOC664422.1.1 m.25505 sp GA45G_RAT 35.606 132 68 4 49 174 23 143 2.39E-14 70.1 GA45G_RAT reviewed Growth arrest and DNA damage-inducible protein GADD45 gamma Gadd45g Rattus norvegicus (Rat) 159 activation of MAPKKK activity [GO:0000185]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]; response to stress [GO:0006950] GO:0000185; GO:0005634; GO:0005737; GO:0006915; GO:0006950; GO:0007275; GO:0030154; GO:0043065; GO:0046330; GO:0051726; GO:1900745 0 0 0 PF01248; A4IF63 CHOYP_LOC100376214.2.11 m.32617 sp TRIM2_BOVIN 26.57 207 146 3 215 417 540 744 2.40E-15 81.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZD32 CHOYP_ISCW_ISCW005933.1.1 m.10948 sp CHD5_RAT 52.778 72 33 1 36 107 125 195 2.40E-18 83.6 CHD5_RAT reviewed Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) Chd5 Rattus norvegicus (Rat) 1948 "cerebral cortex neuron differentiation [GO:0021895]; histone H3-K27 trimethylation [GO:0098532]; histone H4 acetylation [GO:0043967]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription involved in cell fate commitment [GO:0060850]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000792; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0006366; GO:0008026; GO:0008270; GO:0016581; GO:0021895; GO:0035093; GO:0043967; GO:0060850; GO:0061628; GO:0098532; GO:1901798 0 0 0 PF08074;PF08073;PF00385;PF06461;PF06465;PF00271;PF00628;PF00176; E9QHE3 CHOYP_BRAFLDRAFT_117193.1.2 m.8546 sp RN207_DANRE 43.952 587 320 4 3 582 1 585 2.40E-173 513 RN207_DANRE reviewed RING finger protein 207 rnf207b rnf207 Danio rerio (Zebrafish) (Brachydanio rerio) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0005737; GO:0008270; GO:0055117; GO:0086019; GO:1901207; GO:1903762; GO:1903954 0 0 0 PF03915;PF00643; H2A0L0 CHOYP_TYRO1.6.6 m.44318 sp TYRO1_PINMG 30 430 244 18 3 411 7 400 2.40E-33 137 TYRO1_PINMG reviewed Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 492 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; O07552 CHOYP_LOC100180855.4.4 m.66721 sp NHAX_BACSU 34.314 102 62 2 45 146 70 166 2.40E-10 58.9 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O70277 CHOYP_BRAFLDRAFT_79377.11.30 m.32865 sp TRIM3_RAT 24.424 217 151 7 327 538 536 744 2.40E-07 57.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O76463 CHOYP_PHUM_PHUM328150.1.1 m.8592 sp NFT1_CAEEL 50.58 431 207 5 37 466 13 438 2.40E-149 436 NFT1_CAEEL reviewed "Nitrilase and fragile histidine triad fusion protein NitFhit [Includes: Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Diadenosine 5',5'''-P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase); Nitrilase homolog (EC 3.5.-.-)]" nft-1 Y56A3A.13 Caenorhabditis elegans 440 nucleobase-containing compound metabolic process [GO:0006139] GO:0000166; GO:0006139; GO:0016810; GO:0047710 0 0 0 PF00795;PF01230; O96064 CHOYP_MYSP.7.9 m.42321 sp MYSP_MYTGA 65.672 67 23 0 29 95 724 790 2.40E-17 79.7 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P04323 CHOYP_contig_031514 m.36002 sp POL3_DROME 40.773 466 265 4 102 561 163 623 2.40E-112 366 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P10394 CHOYP_LOC100708199.4.6 m.33490 sp POL4_DROME 28.058 139 92 2 10 141 1085 1222 2.40E-09 57.8 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P14248 CHOYP_CLUG_04850.4.4 m.66990 sp RPB1_PLAFD 30.534 131 86 2 139 264 2259 2389 2.40E-07 56.2 RPB1_PLAFD reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) RPII Plasmodium falciparum (isolate CDC / Honduras) 2452 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005665; GO:0006366; GO:0046872 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; P18106 CHOYP_LOC100740500.1.1 m.62319 sp FER_DROME 46.602 103 53 1 183 285 955 1055 2.40E-21 102 FER_DROME reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) FER fps Fps85D HD-179 CG8874 Drosophila melanogaster (Fruit fly) 1325 "actin filament bundle assembly [GO:0051017]; axon guidance [GO:0007411]; dorsal closure [GO:0007391]; dorsal closure, amnioserosa morphology change [GO:0046664]; dorsal closure, elongation of leading edge cells [GO:0007394]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]" GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005543; GO:0005886; GO:0005912; GO:0006468; GO:0007169; GO:0007391; GO:0007394; GO:0007411; GO:0019898; GO:0031234; GO:0038083; GO:0042127; GO:0045087; GO:0046664; GO:0051017 0 0 0 PF00611;PF07714;PF00017; P20273 CHOYP_LOC100880815.4.7 m.51208 sp CD22_HUMAN 26.514 479 282 23 137 586 257 694 2.40E-24 113 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P29590 CHOYP_BRAFLDRAFT_83265.2.2 m.52981 sp PML_HUMAN 31.25 192 99 11 5 183 45 216 2.40E-13 77.4 PML_HUMAN reviewed Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) 882 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006915; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0016925; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045892; GO:0045930; GO:0046982; GO:0048146; GO:0048384; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060333; GO:0060444; GO:0070059; GO:0071353; GO:0090398; GO:0097191; GO:1901796; GO:1902187; GO:1904816; GO:2000059; GO:2000779; GO:2001238 0 0 0 PF12126;PF00643; P50464 CHOYP_LOC658646.1.1 m.50632 sp UNC97_CAEEL 63.636 341 120 2 64 400 4 344 2.40E-165 470 UNC97_CAEEL reviewed LIM domain-containing protein unc-97 (PINCH homolog) (Uncoordinated protein 97) unc-97 F14D12.2 Caenorhabditis elegans 348 cell-cell junction organization [GO:0045216]; muscle organ development [GO:0007517]; sensory perception of mechanical stimulus [GO:0050954] GO:0005634; GO:0005654; GO:0005912; GO:0007517; GO:0008270; GO:0009925; GO:0017022; GO:0031430; GO:0045216; GO:0050954; GO:0055120 0 0 0 PF00412; P57695 CHOYP_LOC100533288.1.1 m.27023 sp GLRA1_BOVIN 45.251 179 93 3 3 180 84 258 2.40E-51 173 GLRA1_BOVIN reviewed Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) GLRA1 Bos taurus (Bovine) 457 "acrosome reaction [GO:0007340]; action potential [GO:0001508]; adult walking behavior [GO:0007628]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; inhibitory postsynaptic potential [GO:0060080]; ion transport [GO:0006811]; muscle contraction [GO:0006936]; negative regulation of transmission of nerve impulse [GO:0051970]; neuromuscular process controlling posture [GO:0050884]; neuropeptide signaling pathway [GO:0007218]; positive regulation of acrosome reaction [GO:2000344]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; response to alcohol [GO:0097305]; response to amino acid [GO:0043200]; righting reflex [GO:0060013]; startle response [GO:0001964]; synaptic transmission, glycinergic [GO:0060012]; visual perception [GO:0007601]" GO:0001508; GO:0001964; GO:0002087; GO:0005887; GO:0006811; GO:0006821; GO:0006936; GO:0007218; GO:0007340; GO:0007601; GO:0007628; GO:0008270; GO:0009897; GO:0016594; GO:0016934; GO:0022824; GO:0030054; GO:0030425; GO:0030977; GO:0034707; GO:0043005; GO:0043025; GO:0043200; GO:0043204; GO:0043231; GO:0045202; GO:0045211; GO:0050884; GO:0051970; GO:0060012; GO:0060013; GO:0060077; GO:0060080; GO:0071230; GO:0071294; GO:0071361; GO:0097305; GO:2000344 0 0 0 PF02931;PF02932; P85971 CHOYP_LOC100371875.1.1 m.29467 sp 6PGL_RAT 47.791 249 119 5 1 240 1 247 2.40E-71 221 6PGL_RAT reviewed 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) Pgls Rattus norvegicus (Rat) 257 "carbohydrate metabolic process [GO:0005975]; pentose-phosphate shunt, oxidative branch [GO:0009051]" GO:0005737; GO:0005975; GO:0009051; GO:0017057; GO:0048029 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. {ECO:0000250|UniProtKB:O95336}. 0 cd01400; PF01182; Q06577 CHOYP_MSB_A0291.1.1 m.50314 sp HP27_TAMSI 30.579 121 80 4 215 333 96 214 2.40E-06 51.2 HP27_TAMSI reviewed Hibernation-associated plasma protein HP-27 (Hibernator-specific blood complex 27 kDa subunit) 0 Tamias sibiricus (Siberian chipmunk) (Eutamias sibiricus) 215 hibernation [GO:0042750] GO:0005576; GO:0005581; GO:0042750 0 0 0 PF00386;PF01391; Q28IB1 CHOYP_ISCW_ISCW010912.1.1 m.11632 sp NUDC1_XENTR 33.475 236 148 5 2 231 162 394 2.40E-31 124 NUDC1_XENTR reviewed NudC domain-containing protein 1 nudcd1 TEgg071c06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 586 0 GO:0005634; GO:0005737 0 0 0 PF04969; Q2YDC9 CHOYP_BRAFLDRAFT_79292.1.2 m.15891 sp PDCD2_BOVIN 48.503 167 72 2 10 167 9 170 2.40E-46 157 PDCD2_BOVIN reviewed Programmed cell death protein 2 PDCD2 Bos taurus (Bovine) 344 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; regulation of hematopoietic progenitor cell differentiation [GO:1901532] GO:0003677; GO:0005634; GO:0005737; GO:0006915; GO:0006919; GO:0046872; GO:0070062; GO:1901532; GO:1902035 0 0 0 PF04194;PF01753; Q3U1D0 CHOYP_LOC100546460.1.1 m.16525 sp LINES_MOUSE 25.532 282 166 8 3 253 350 618 2.40E-16 84 LINES_MOUSE reviewed Protein Lines homolog 1 (Protein Lines homolog 2) (Wnt-signaling molecule Lines homolog 1) Lins1 Lins Lins2 Wins2 Mus musculus (Mouse) 764 cognition [GO:0050890] GO:0050890 0 0 0 PF14695;PF14694; Q497Q6 CHOYP_LOC100372845.1.3 m.7734 sp F228B_MOUSE 26.087 230 138 4 74 299 24 225 2.40E-19 88.6 F228B_MOUSE reviewed Protein FAM228B Fam228b Mus musculus (Mouse) 232 0 0 0 0 0 0 Q4PMB3 CHOYP_RS4.1.11 m.10005 sp RS4_IXOSC 73.846 260 67 1 18 277 3 261 2.40E-138 393 RS4_IXOSC reviewed 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) 262 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q4R6I1 CHOYP_contig_050449 m.60020 sp GIN1_MACFA 36.364 55 33 1 9 61 62 116 2.40E-06 48.1 GIN1_MACFA reviewed Gypsy retrotransposon integrase-like protein 1 (GIN-1) GIN1 QtsA-18003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 522 DNA integration [GO:0015074] GO:0003676; GO:0015074 0 0 0 0 Q5RCR5 CHOYP_SUMF2.1.1 m.40604 sp SUMF2_PONAB 49.632 272 129 3 49 319 30 294 2.40E-90 276 SUMF2_PONAB reviewed Sulfatase-modifying factor 2 (C-alpha-formylglycine-generating enzyme 2) SUMF2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 301 0 GO:0005788; GO:0046872 0 0 0 PF03781; Q69ZS0 CHOYP_PDZRN3.1.1 m.18229 sp PZRN3_MOUSE 38.392 659 308 27 2 613 210 817 2.40E-90 312 PZRN3_MOUSE reviewed E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) Pdzrn3 Kiaa1095 Semcap3 Mus musculus (Mouse) 1063 neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] GO:0004842; GO:0007528; GO:0008270; GO:0016567; GO:0016874; GO:0031594; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00595; Q6AYP6 CHOYP_BRAFLDRAFT_128825.1.1 m.10785 sp SAXO1_RAT 30.268 261 140 14 70 318 151 381 2.40E-08 59.7 SAXO1_RAT reviewed Stabilizer of axonemal microtubules 1 Saxo1 Fam154a Rattus norvegicus (Rat) 462 cell projection organization [GO:0030030]; cellular response to cold [GO:0070417]; cold acclimation [GO:0009631]; positive regulation of cilium assembly [GO:0045724] GO:0005814; GO:0005879; GO:0008017; GO:0009631; GO:0030030; GO:0031512; GO:0036064; GO:0036126; GO:0045724; GO:0070417 0 0 0 0 Q6PCL0 CHOYP_TBX3-B.1.1 m.46126 sp TBX2B_XENLA 63.284 335 110 6 13 336 11 343 2.40E-135 415 TBX2B_XENLA reviewed T-box transcription factor TBX2-B (T-box protein 2-B) tbx2-b Xenopus laevis (African clawed frog) 691 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351 0 0 0 PF00907;PF12598; Q6PFY8 CHOYP_LOC100373444.75.79 m.61658 sp TRI45_MOUSE 29.032 248 155 6 5 239 127 366 2.40E-14 79.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7J1 CHOYP_Y028.1.1 m.30886 sp Y033_OSHVF 99.187 123 1 0 1 123 174 296 2.40E-86 256 Y033_OSHVF reviewed Uncharacterized protein ORF33 ORF33 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 296 0 0 0 0 0 0 Q80YE2 CHOYP_BRAFLDRAFT_117676.1.1 m.13577 sp T53I1_RAT 30.702 228 141 6 25 244 20 238 2.40E-18 84.3 T53I1_RAT reviewed Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (Thymus-expressed acidic protein) (TEAP) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) Trp53inp1 Sip Rattus norvegicus (Rat) 239 "apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000045; GO:0005634; GO:0005776; GO:0005829; GO:0006351; GO:0006915; GO:0008285; GO:0010508; GO:0016209; GO:0016605; GO:0030336; GO:0031410; GO:0045893; GO:0048102 0 0 0 PF14839; Q8ICR0 CHOYP_BRAFLDRAFT_76536.1.2 m.365 sp CDPK2_PLAF7 25.481 208 146 5 748 951 93 295 2.40E-09 64.7 CDPK2_PLAF7 reviewed Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2) CPK2 CDPK2 MAL6P1.108 PFF0520w Plasmodium falciparum (isolate 3D7) 509 intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0009931; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; Q8IYJ2 CHOYP_LOC100893805.1.1 m.47273 sp CJ067_HUMAN 39.063 64 39 0 108 171 423 486 2.40E-08 58.5 CJ067_HUMAN reviewed "Uncharacterized protein C10orf67, mitochondrial" C10orf67 LINC01552 Homo sapiens (Human) 551 0 GO:0005739 0 0 0 PF15821;PF15852; Q8K2R5 CHOYP_ZFP28.1.1 m.719 sp ZN668_MOUSE 25.806 403 230 16 208 566 18 395 2.40E-23 108 ZN668_MOUSE reviewed Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q8MJS1 CHOYP_DVIR_GJ15619.2.2 m.65678 sp I12R2_PIG 23.679 511 323 28 221 712 202 664 2.40E-07 58.5 I12R2_PIG reviewed Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2) IL12RB2 Sus scrofa (Pig) 861 0 GO:0004896; GO:0016021 0 0 0 PF00041;PF06328; Q8NBN7 CHOYP_RDH13.1.3 m.10434 sp RDH13_HUMAN 52.091 263 122 3 75 333 9 271 2.40E-81 253 RDH13_HUMAN reviewed Retinol dehydrogenase 13 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 7C member 3) RDH13 SDR7C3 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) 331 eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842] GO:0005743; GO:0009644; GO:0010842; GO:0016491; GO:0042462; GO:0052650 0 0 0 PF00106; Q8TC57 CHOYP_M1AP.1.1 m.46301 sp M1AP_HUMAN 30.972 494 311 6 11 499 17 485 2.40E-75 250 M1AP_HUMAN reviewed Meiosis 1 arrest protein (Meiosis 1-arresting protein) (Meiosis 1-associated protein) (Spermatogenesis-associated protein 37) M1AP C2orf65 SPATA37 Homo sapiens (Human) 530 cell differentiation [GO:0030154]; chromatin assembly [GO:0031497]; female gamete generation [GO:0007292]; male meiosis chromosome separation [GO:0051308]; meiosis I [GO:0007127]; RNA processing [GO:0006396]; spermatogenesis [GO:0007283] GO:0005737; GO:0006396; GO:0007127; GO:0007283; GO:0007292; GO:0016021; GO:0030154; GO:0031497; GO:0051308 0 0 0 0 Q8TCU4 CHOYP_BRAFLDRAFT_97626.1.1 m.26304 sp ALMS1_HUMAN 25.806 217 119 4 2580 2793 3983 4160 2.40E-14 84 ALMS1_HUMAN reviewed Alstrom syndrome protein 1 ALMS1 KIAA0328 Homo sapiens (Human) 4167 endosomal transport [GO:0016197]; G2/M transition of mitotic cell cycle [GO:0000086]; regulation of stress fiber assembly [GO:0051492] GO:0000086; GO:0000922; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0005929; GO:0016197; GO:0051492 0 0 0 PF15309; Q91WM2 CHOYP_BRAFLDRAFT_279146.1.1 m.18142 sp CECR5_MOUSE 42.857 413 195 6 32 431 34 418 2.40E-113 342 CECR5_MOUSE reviewed Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) 419 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q921X9 CHOYP_LOC100372340.1.3 m.9116 sp PDIA5_MOUSE 44.489 499 258 8 43 527 7 500 2.40E-138 421 PDIA5_MOUSE reviewed Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) Pdia5 Pdir Mus musculus (Mouse) 517 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005783; GO:0005788; GO:0006457; GO:0034976; GO:0045454 0 0 0 PF00085; Q96MM6 CHOYP_LOC100488894.2.5 m.21667 sp HS12B_HUMAN 25.506 247 150 10 11 239 455 685 2.40E-15 78.2 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99PT3 CHOYP_RAA1E.1.1 m.16615 sp IN80B_MOUSE 36.364 275 139 7 121 359 84 358 2.40E-29 119 IN80B_MOUSE reviewed INO80 complex subunit B (High mobility group AT-hook 1-like 4) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) Ino80b Hmga1l4 Papa1 Znhit4 Mus musculus (Mouse) 375 "chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006281; GO:0006310; GO:0006338; GO:0006351; GO:0006355; GO:0031011; GO:0046872 0 0 0 PF04795;PF04438; Q9DC07 CHOYP_LOC663855.2.5 m.747 sp LNEBL_MOUSE 36.986 292 135 6 1 281 1 254 2.40E-54 180 LNEBL_MOUSE reviewed LIM zinc-binding domain-containing Nebulette (Actin-binding Z-disk protein) Nebl Lnebl Mus musculus (Mouse) 270 0 GO:0005737; GO:0008270 0 0 0 PF00412;PF00880;PF14604; Q9R1R2 CHOYP_LOC100645486.1.1 m.24567 sp TRIM3_MOUSE 26.273 746 449 18 15 675 13 742 2.40E-68 241 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U943 CHOYP_ISCW_ISCW009032.1.1 m.6092 sp APLP_LOCMI 27.536 207 141 4 685 882 2698 2904 2.40E-14 81.6 APLP_LOCMI reviewed Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] 0 Locusta migratoria (Migratory locust) 3380 Wnt signaling pathway [GO:0016055] GO:0005319; GO:0005576; GO:0008289; GO:0016055 0 0 0 PF08742;PF06448;PF09172;PF01347;PF00094; Q9WV26 CHOYP_CLTR1.1.2 m.1661 sp AGTR1_CAVPO 25.382 327 187 12 47 334 42 350 2.40E-09 62 AGTR1_CAVPO reviewed Type-1 angiotensin II receptor (Angiotensin II type-1 receptor) (AT1) AGTR1 Cavia porcellus (Guinea pig) 359 calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; kidney development [GO:0001822]; positive regulation of cellular protein metabolic process [GO:0032270]; positive regulation of cholesterol esterification [GO:0010873]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482]; positive regulation of phospholipase A2 activity [GO:0032430]; regulation of vasoconstriction [GO:0019229]; Rho protein signal transduction [GO:0007266] GO:0001596; GO:0001822; GO:0004945; GO:0005829; GO:0005886; GO:0007266; GO:0010873; GO:0016021; GO:0019229; GO:0019722; GO:0032270; GO:0032430; GO:0051482; GO:0060326 0 0 0 PF00001; Q9Y2C9 CHOYP_BRAFLDRAFT_87578.3.3 m.45585 sp TLR6_HUMAN 32.075 106 71 1 94 199 641 745 2.40E-07 57.4 TLR6_HUMAN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) 796 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0038124; GO:0042088; GO:0042496; GO:0042742; GO:0043123; GO:0043507; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; Q9Y5Y3 CHOYP_LOC100373904.1.1 m.4756 sp GPR45_HUMAN 37.135 342 206 2 30 366 26 363 2.40E-71 230 GPR45_HUMAN reviewed Probable G-protein coupled receptor 45 (PSP24-1) (PSP24-alpha) GPR45 Homo sapiens (Human) 372 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; O08848 CHOYP_RO60.1.6 m.24126 sp RO60_MOUSE 30.246 529 337 13 4 523 28 533 2.41E-73 246 RO60_MOUSE reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0034336; GO:0046872; GO:0060271 0 0 0 PF05731; O08863 CHOYP_LOC100741028.1.4 m.34926 sp BIRC3_MOUSE 29.609 358 197 9 736 1049 254 600 2.41E-46 180 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; O14756 CHOYP_H17B6.1.1 m.55928 sp H17B6_HUMAN 40 320 183 6 20 334 1 316 2.41E-68 219 H17B6_HUMAN reviewed 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.239) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6) HSD17B6 RODH SDR9C6 Homo sapiens (Human) 317 androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; steroid metabolic process [GO:0008202] GO:0003824; GO:0004303; GO:0004745; GO:0005622; GO:0005783; GO:0006702; GO:0006710; GO:0008202; GO:0009055; GO:0016491; GO:0031901; GO:0047035 0 0 0 PF00106; O15040 CHOYP_BRAFLDRAFT_216841.2.4 m.42281 sp TCPR2_HUMAN 33.333 624 378 15 744 1339 798 1411 2.41E-98 348 TCPR2_HUMAN reviewed Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) 1411 autophagy [GO:0006914] GO:0006914 0 0 0 PF06462; O43301 CHOYP_BRAFLDRAFT_242762.3.8 m.20476 sp HS12A_HUMAN 30.612 245 140 7 39 275 451 673 2.41E-25 108 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O70277 CHOYP_LOC100369333.16.32 m.32970 sp TRIM3_RAT 24.901 253 169 9 309 554 506 744 2.41E-10 67 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70511 CHOYP_LOC100641396.3.27 m.3920 sp ANK3_RAT 30.182 550 357 19 5 533 240 783 2.41E-43 169 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O75382 CHOYP_BRAFLDRAFT_102380.5.11 m.33021 sp TRIM3_HUMAN 23.396 265 184 9 110 363 486 742 2.41E-09 62.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O89094 CHOYP_CASP7.8.23 m.23670 sp CASPE_MOUSE 27.273 220 121 9 47 255 41 232 2.41E-12 68.9 CASPE_MOUSE reviewed "Caspase-14 (CASP-14) (EC 3.4.22.-) (Mini-ICE) (MICE) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]" Casp14 Mus musculus (Mouse) 257 cornification [GO:0070268] GO:0005634; GO:0005737; GO:0008233; GO:0045095; GO:0070062; GO:0070268; GO:0097153 0 0 0 0 P01130 CHOYP_LDLR.5.7 m.38150 sp LDLR_HUMAN 59.091 66 26 1 75 139 80 145 2.41E-18 83.6 LDLR_HUMAN reviewed Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899] GO:0001618; GO:0001948; GO:0002020; GO:0004872; GO:0005041; GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005887; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0008203; GO:0009897; GO:0009986; GO:0010008; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0030669; GO:0032050; GO:0034362; GO:0034383; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0070508; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P06731 CHOYP_CEAM5.3.6 m.49578 sp CEAM5_HUMAN 25.141 354 213 15 9 359 200 504 2.41E-14 79 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; P10155 CHOYP_LOC100377747.1.3 m.22462 sp RO60_HUMAN 45.366 205 105 3 24 226 5 204 2.41E-59 198 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P20072 CHOYP_LOC100367736.2.2 m.66862 sp ANXA7_BOVIN 57.235 311 133 0 4 314 153 463 2.41E-129 379 ANXA7_BOVIN reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 Bos taurus (Bovine) 463 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005509; GO:0005544; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0030855; GO:0035176; GO:0042584; GO:0042802; GO:0044822; GO:0048306; GO:0070062 0 0 0 PF00191; P20825 CHOYP_POL4.2.4 m.35980 sp POL2_DROME 40.367 327 182 7 4 323 361 681 2.41E-63 234 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P22448 CHOYP_RARB.3.3 m.54034 sp RARB_CHICK 57.465 355 130 2 78 429 83 419 2.41E-144 422 RARB_CHICK reviewed Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2) RARB NR1B2 Gallus gallus (Chicken) 455 "beak morphogenesis [GO:0071729]; embryonic digestive tract development [GO:0048566]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration [GO:0070660]; limb morphogenesis [GO:0035108]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to retinoic acid [GO:0032526]; retinal pigment epithelium development [GO:0003406]; striatum development [GO:0021756]; transcription, DNA-templated [GO:0006351]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]" GO:0000122; GO:0000977; GO:0001657; GO:0002068; GO:0003148; GO:0003406; GO:0003417; GO:0003707; GO:0003708; GO:0005623; GO:0005654; GO:0006351; GO:0008270; GO:0008284; GO:0008285; GO:0021756; GO:0032331; GO:0032526; GO:0035108; GO:0035116; GO:0035264; GO:0043065; GO:0043066; GO:0045944; GO:0048048; GO:0048471; GO:0048566; GO:0055012; GO:0070660; GO:0071729 0 0 0 PF00104;PF00105; P23469 CHOYP_MEG10.83.91 m.61586 sp PTPRE_HUMAN 33.392 572 320 19 804 1337 115 663 2.41E-75 268 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P33215 CHOYP_NEDD1.1.1 m.10741 sp NEDD1_MOUSE 35.371 687 381 17 5 660 6 660 2.41E-120 375 NEDD1_MOUSE reviewed Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) Nedd1 Nedd-1 Mus musculus (Mouse) 660 cell division [GO:0051301]; microtubule depolymerization [GO:0007019]; microtubule polymerization or depolymerization [GO:0031109]; mitotic nuclear division [GO:0007067]; protein localization to centrosome [GO:0071539]; regulation of establishment of protein localization [GO:0070201] GO:0000242; GO:0000922; GO:0000924; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0007019; GO:0007067; GO:0031109; GO:0036064; GO:0045177; GO:0051301; GO:0070201; GO:0071539 0 0 0 PF00400; P35979 CHOYP_LOC100908688.1.5 m.30293 sp RL12_MOUSE 69.492 118 36 0 3 120 46 163 2.41E-56 175 RL12_MOUSE reviewed 60S ribosomal protein L12 Rpl12 Mus musculus (Mouse) 165 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022625; GO:0044822; GO:0070062 0 0 cd00349; PF00298;PF03946; P41116 CHOYP_LOC100207178.1.1 m.22937 sp RL8_XENLA 80.859 256 49 0 1 256 1 256 2.41E-151 425 RL8_XENLA reviewed 60S ribosomal protein L8 rpl8 Xenopus laevis (African clawed frog) 257 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934; GO:0019843 0 0 0 PF00181;PF03947; P46012 CHOYP_LOC587946.1.1 m.5037 sp YKI5_CAEEL 35.915 142 73 6 6 131 3 142 2.41E-12 73.6 YKI5_CAEEL reviewed Uncharacterized protein C01G6.5 C01G6.5 Caenorhabditis elegans 952 0 0 0 0 0 PF00498; P48544 CHOYP_LOC100875023.1.1 m.53883 sp KCNJ5_HUMAN 48.593 391 172 6 71 458 46 410 2.41E-132 391 KCNJ5_HUMAN reviewed "G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)" KCNJ5 GIRK4 Homo sapiens (Human) 419 potassium ion import [GO:0010107]; potassium ion transport [GO:0006813] GO:0005886; GO:0006813; GO:0008076; GO:0009897; GO:0010107; GO:0015467; GO:0030315 0 0 0 PF01007; P62083 CHOYP_RS7.8.9 m.63523 sp RS7_RAT 84.81 158 22 2 1 156 2 159 2.41E-91 266 RS7_RAT reviewed 40S ribosomal protein S7 (S8) Rps7 Rattus norvegicus (Rat) 194 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0003735; GO:0005815; GO:0006364; GO:0006412; GO:0008266; GO:0022627; GO:0030686; GO:0032040; GO:0042274 0 0 0 PF01251; P81942 CHOYP_GSTP1.2.2 m.30099 sp GSTP1_BUFBU 47.805 205 104 1 6 207 5 209 2.41E-59 188 GSTP1_BUFBU reviewed Glutathione S-transferase P 1 (EC 2.5.1.18) (BBGSTP1-1) (GST class-pi) 0 Bufo bufo (European toad) 210 metabolic process [GO:0008152] GO:0004364; GO:0005634; GO:0005739; GO:0008152 0 0 0 PF14497;PF02798; Q04799 CHOYP_FMO5.6.6 m.47993 sp FMO5_RABIT 54.077 233 106 1 98 330 236 467 2.41E-76 246 FMO5_RABIT reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (FMO 1C1) (FMO form 3) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Oryctolagus cuniculus (Rabbit) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; Q08BL7 CHOYP_LOC585085.1.1 m.55307 sp GLCTK_DANRE 41.245 514 278 6 66 576 9 501 2.41E-131 396 GLCTK_DANRE reviewed Glycerate kinase (EC 2.7.1.31) glyctk zgc:153346 Danio rerio (Zebrafish) (Brachydanio rerio) 502 protein phosphorylation [GO:0006468] GO:0005524; GO:0005737; GO:0006468; GO:0008887 0 0 0 PF13660;PF05161; Q14162 CHOYP_CELE_Y64G10A.7.1.4 m.15634 sp SREC_HUMAN 29.553 291 132 13 1 261 140 387 2.41E-17 85.1 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q15637 CHOYP_RPC1.1.1 m.16568 sp SF01_HUMAN 67.665 334 96 3 62 394 15 337 2.41E-155 464 SF01_HUMAN reviewed Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162) SF1 ZFM1 ZNF162 Homo sapiens (Human) 639 "Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of smooth muscle cell proliferation [GO:0048662]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription, DNA-templated [GO:0006355]; spliceosomal complex assembly [GO:0000245]; transcription, DNA-templated [GO:0006351]" GO:0000245; GO:0000389; GO:0000398; GO:0003714; GO:0003723; GO:0005634; GO:0005654; GO:0005681; GO:0005840; GO:0006351; GO:0006355; GO:0008270; GO:0030238; GO:0033327; GO:0042802; GO:0044822; GO:0048662; GO:0050810 0 0 0 PF00013;PF16275;PF00098; Q3T168 CHOYP_SIP.1.1 m.5724 sp CYBP_BOVIN 40 205 109 5 5 202 7 204 2.41E-34 125 CYBP_BOVIN reviewed Calcyclin-binding protein (CacyBP) CACYBP Bos taurus (Bovine) 230 0 GO:0005641; GO:0005654; GO:0030877; GO:0070062 0 0 0 PF04969;PF05002;PF09032; Q4GZT3 CHOYP_LOC100198291.1.1 m.66169 sp PKD2_BOVIN 24.583 240 176 1 1 240 474 708 2.41E-18 89.7 PKD2_BOVIN reviewed Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2) PKD2 TRPP2 Bos taurus (Bovine) 970 "aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell cycle arrest [GO:0007050]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; heart looping [GO:0001947]; JAK-STAT cascade [GO:0007259]; mesonephric duct development [GO:0072177]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric smooth muscle tissue development [GO:0072208]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cAMP metabolic process [GO:0030814]; regulation of cell proliferation [GO:0042127]; renal artery morphogenesis [GO:0061441]; spinal cord development [GO:0021510]" GO:0001658; GO:0001892; GO:0001947; GO:0002133; GO:0003127; GO:0005245; GO:0005248; GO:0005262; GO:0005267; GO:0005509; GO:0005887; GO:0005911; GO:0007050; GO:0007259; GO:0009925; GO:0016020; GO:0021510; GO:0021915; GO:0030027; GO:0030814; GO:0031512; GO:0031513; GO:0031587; GO:0031659; GO:0031941; GO:0035502; GO:0035904; GO:0036064; GO:0042127; GO:0042994; GO:0045180; GO:0045429; GO:0045944; GO:0048763; GO:0050982; GO:0060170; GO:0060315; GO:0060674; GO:0061441; GO:0070062; GO:0071158; GO:0071458; GO:0071464; GO:0071470; GO:0071498; GO:0071556; GO:0071910; GO:0072075; GO:0072177; GO:0072208; GO:0072214; GO:0072218; GO:0072219; GO:0072235; GO:0072284; GO:0072686; GO:2000134 0 0 0 PF08016; Q4R8G6 CHOYP_NEMVEDRAFT_V1G210850.1.1 m.45130 sp MEIOB_MACFA 38.445 463 265 8 62 519 13 460 2.41E-98 308 MEIOB_MACFA reviewed Meiosis-specific with OB domain-containing protein (EC 3.1.-.-) MEIOB QtsA-12515 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 471 double-strand break repair via homologous recombination [GO:0000724]; female meiosis I [GO:0007144]; fertilization [GO:0009566]; male meiosis [GO:0007140]; resolution of meiotic recombination intermediates [GO:0000712]; synapsis [GO:0007129] GO:0000712; GO:0000724; GO:0003682; GO:0003697; GO:0005634; GO:0005694; GO:0005737; GO:0007129; GO:0007140; GO:0007144; GO:0008310; GO:0009566 0 0 0 PF16900; Q561R0 CHOYP_BRAFLDRAFT_131834.1.1 m.29489 sp MZB1_RAT 36.364 165 96 4 53 210 26 188 2.41E-28 108 MZB1_RAT reviewed Marginal zone B- and B1-cell-specific protein (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein) Mzb1 Pacap Rattus norvegicus (Rat) 188 integrin activation [GO:0033622]; negative regulation of glucose import in response to insulin stimulus [GO:2001274]; positive regulation of cell proliferation [GO:0008284]; positive regulation of immunoglobulin biosynthetic process [GO:0002642]; regulation of B cell proliferation [GO:0030888]; regulation of cell proliferation [GO:0042127] GO:0002642; GO:0005576; GO:0005788; GO:0008284; GO:0030888; GO:0033622; GO:0034663; GO:0042127; GO:2001274 0 0 0 PF11938; Q64512 CHOYP_PTP.1.1 m.7249 sp PTN13_MOUSE 33.11 598 342 17 2007 2554 1851 2440 2.41E-68 261 PTN13_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (PTP36) (Protein tyrosine phosphatase DPZPTP) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) Ptpn13 Ptp14 Mus musculus (Mouse) 2453 peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066] GO:0004725; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0006470; GO:0014066; GO:0030027; GO:0030496; GO:0035335; GO:0036312; GO:0070062 0 0 0 PF09380;PF00373;PF09379;PF00595;PF00102; Q6DIB5 CHOYP_contig_018688 m.21935 sp MEG10_MOUSE 37.24 384 210 18 1 377 240 599 2.41E-47 176 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6PFY8 CHOYP_LOC100368020.29.29 m.60179 sp TRI45_MOUSE 27.673 159 99 5 11 154 133 290 2.41E-06 49.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q86XE3 CHOYP_AGAP_AGAP004179.1.1 m.33303 sp MICU3_HUMAN 47.654 405 155 5 68 419 129 529 2.41E-116 353 MICU3_HUMAN reviewed "Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)" MICU3 EFHA2 Homo sapiens (Human) 530 0 GO:0005509; GO:0005739; GO:0016021 0 0 0 PF13833; Q8IN94 CHOYP_LOC100883763.1.1 m.4011 sp OSA_DROME 38.684 760 370 16 1884 2566 1768 2508 2.41E-136 483 OSA_DROME reviewed Trithorax group protein osa (Protein eyelid) osa eld CG7467 Drosophila melanogaster (Fruit fly) 2716 "adult chitin-containing cuticle pigmentation [GO:0048085]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; negative regulation of neuroblast proliferation [GO:0007406]; neuroblast fate commitment [GO:0014017]; neurogenesis [GO:0022008]; photoreceptor cell differentiation [GO:0046530]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; segment specification [GO:0007379]; sensory perception of pain [GO:0019233]; transcription, DNA-templated [GO:0006351]; wing disc dorsal/ventral pattern formation [GO:0048190]; Wnt signaling pathway [GO:0016055]" GO:0003677; GO:0005634; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0006357; GO:0007379; GO:0007406; GO:0007476; GO:0007480; GO:0008586; GO:0008587; GO:0014017; GO:0016055; GO:0016569; GO:0019233; GO:0022008; GO:0035060; GO:0042058; GO:0045893; GO:0046530; GO:0048085; GO:0048190 0 0 0 PF01388;PF12031; Q8VCM3 CHOYP_LOC763340.1.1 m.60271 sp ZFY21_MOUSE 46.053 228 110 7 6 227 12 232 2.41E-58 187 ZFY21_MOUSE reviewed Zinc finger FYVE domain-containing protein 21 Zfyve21 Mus musculus (Mouse) 234 0 GO:0005768; GO:0005925; GO:0016023; GO:0046872 0 0 0 PF01363;PF16696; Q90Z12 CHOYP_HES1.2.3 m.27001 sp HES4A_XENLA 39.145 304 126 9 20 321 35 281 2.41E-51 174 HES4A_XENLA reviewed Transcription factor HES-4-A (Hairy and enhancer of split 4-A) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2a) hes4-a hairy2 hairy2a Xenopus laevis (African clawed frog) 281 "BMP signaling pathway [GO:0030509]; cell proliferation [GO:0008283]; floor plate development [GO:0033504]; lens development in camera-type eye [GO:0002088]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural crest formation [GO:0014029]; prechordal plate formation [GO:0021501]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002088; GO:0005634; GO:0006351; GO:0008283; GO:0014029; GO:0021501; GO:0030509; GO:0033504; GO:0043066; GO:0043425; GO:0043565; GO:0045892 0 0 0 PF07527;PF00010; Q96GP6 CHOYP_BRAFLDRAFT_224574.13.18 m.47524 sp SREC2_HUMAN 39.336 211 111 8 201 407 236 433 2.41E-28 121 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9DCL2 CHOYP_NEMVEDRAFT_V1G246622.1.1 m.24513 sp FA96A_MOUSE 66.667 117 38 1 20 135 40 156 2.41E-50 160 FA96A_MOUSE reviewed MIP18 family protein FAM96A Fam96a Mus musculus (Mouse) 160 chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226] GO:0005634; GO:0005654; GO:0005737; GO:0007059; GO:0016226; GO:0046872 0 0 0 PF01883; Q9TU34 CHOYP_TRIADDRAFT_55241.1.1 m.41679 sp ITPR1_BOVIN 22.881 1534 900 50 29 1366 5 1451 2.41E-74 281 ITPR1_BOVIN reviewed "Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)" ITPR1 Bos taurus (Bovine) 2709 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; release of sequestered calcium ion into cytosol [GO:0051209] GO:0005220; GO:0005789; GO:0005791; GO:0015278; GO:0016021; GO:0030141; GO:0030658; GO:0035091; GO:0051209; GO:0070059 0 0 0 PF08709;PF00520;PF02815;PF08454;PF01365; Q9Y259 CHOYP_CHKA.1.1 m.25454 sp CHKB_HUMAN 43.094 362 199 2 46 407 31 385 2.41E-110 332 CHKB_HUMAN reviewed Choline/ethanolamine kinase (Choline kinase beta) (CK) (CKB) (EC 2.7.1.32) (Choline kinase-like protein) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (Ethanolamine kinase beta) (EKB) (choline/ethanolamine kinase beta) (CKEKB) CHKB CHETK CHKL Homo sapiens (Human) 395 phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646] GO:0004103; GO:0004305; GO:0005524; GO:0005829; GO:0006646; GO:0006656 PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. 0 0 0 Q9Y7M3 CHOYP_LOC100367312.7.13 m.37567 sp YNT3_SCHPO 38.961 77 43 2 45 119 144 218 2.41E-09 59.3 YNT3_SCHPO reviewed FYVE-type zinc finger-containing protein C9B6.03 SPBC9B6.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 293 endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; Golgi to endosome transport [GO:0006895]; Golgi to vacuole transport [GO:0006896]; vacuole inheritance [GO:0000011] GO:0000011; GO:0000324; GO:0005829; GO:0006895; GO:0006896; GO:0006897; GO:0010009; GO:0017137; GO:0034058; GO:0046872 0 0 0 PF01363; A2BG43 CHOYP_LOC100377267.1.1 m.49876 sp GLTP_DANRE 32.487 197 127 3 25 216 11 206 2.42E-31 116 GLTP_DANRE reviewed Glycolipid transfer protein (GLTP) gltp si:dkey-234h16.2 Danio rerio (Zebrafish) (Brachydanio rerio) 209 0 GO:0005737; GO:0017089; GO:0051861 0 0 0 PF08718; A7MBP4 CHOYP_LOC590756.1.6 m.19283 sp IFT46_DANRE 65.476 252 76 2 141 392 143 383 2.42E-110 331 IFT46_DANRE reviewed Intraflagellar transport protein 46 homolog ift46 Danio rerio (Zebrafish) (Brachydanio rerio) 384 cilium assembly [GO:0042384]; determination of ventral identity [GO:0048264]; intraciliary transport [GO:0042073]; pronephros development [GO:0048793]; retina development in camera-type eye [GO:0060041] GO:0005737; GO:0005813; GO:0030992; GO:0036064; GO:0042073; GO:0042384; GO:0048264; GO:0048793; GO:0060041 0 0 0 PF12317; D2GXS7 CHOYP_BRAFLDRAFT_69765.7.23 m.32764 sp TRIM2_AILME 32.075 106 68 3 23 125 627 731 2.42E-09 57.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15360 CHOYP_FANCA.1.1 m.16219 sp FANCA_HUMAN 36.91 466 265 10 1 450 338 790 2.42E-80 290 FANCA_HUMAN reviewed Fanconi anemia group A protein (Protein FACA) FANCA FAA FACA FANCH Homo sapiens (Human) 1455 DNA repair [GO:0006281]; female gonad development [GO:0008585]; interstrand cross-link repair [GO:0036297]; male gonad development [GO:0008584]; male meiosis [GO:0007140]; protein complex assembly [GO:0006461]; regulation of cell proliferation [GO:0042127] GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006461; GO:0007140; GO:0008584; GO:0008585; GO:0036297; GO:0042127; GO:0043240 0 0 0 PF03511;PF15865; P02259 CHOYP_LOC100635715.4.9 m.11453 sp H5_CHICK 42 150 74 4 29 171 1 144 2.42E-22 93.2 H5_CHICK reviewed Histone H5 0 Gallus gallus (Chicken) 190 chromosome condensation [GO:0030261]; nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0030261 0 0 0 PF00538; P09917 CHOYP_LOC584481.1.10 m.1503 sp LOX5_HUMAN 31.424 681 433 15 3 659 4 674 2.42E-108 345 LOX5_HUMAN reviewed Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase) (EC 1.13.11.34) ALOX5 LOG5 Homo sapiens (Human) 674 acute inflammatory response [GO:0002526]; arachidonic acid metabolic process [GO:0019369]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; leukotriene production involved in inflammatory response [GO:0002540]; lipoxin metabolic process [GO:2001300]; lipoxygenase pathway [GO:0019372]; positive regulation of vasoconstriction [GO:0045907]; response to hyperoxia [GO:0055093]; response to nutrient [GO:0007584]; sensory perception of pain [GO:0019233] GO:0002526; GO:0002540; GO:0004051; GO:0005506; GO:0005615; GO:0005635; GO:0005641; GO:0005829; GO:0006691; GO:0007584; GO:0016363; GO:0019233; GO:0019369; GO:0019370; GO:0019372; GO:0030425; GO:0031965; GO:0042383; GO:0045907; GO:0055093; GO:2001300 PATHWAY: Lipid metabolism; leukotriene A4 biosynthesis. 0 0 PF00305;PF01477; P13520 CHOYP_contig_018916 m.22175 sp VOLD_BPP2 26.627 169 104 5 345 502 296 455 2.42E-07 57 VOLD_BPP2 reviewed Overcoming lysogenization defect protein old Enterobacteria phage P2 (Bacteriophage P2) 586 0 0 0 0 0 0 P21328 CHOYP_LOC100892567.7.8 m.51724 sp RTJK_DROME 22.474 881 583 29 142 962 6 846 2.42E-42 171 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P23286 CHOYP_CDPKM.1.1 m.58179 sp CALM_CANAX 37.762 143 82 4 1 137 1 142 2.42E-21 86.7 CALM_CANAX reviewed Calmodulin (CaM) CMD1 Candida albicans (Yeast) 149 0 GO:0005509 0 0 0 PF13499; P28715 CHOYP_LOC101173290.1.1 m.43300 sp ERCC5_HUMAN 43.511 393 192 7 503 882 644 1019 2.42E-87 308 ERCC5_HUMAN reviewed DNA repair protein complementing XP-G cells (EC 3.1.-.-) (DNA excision repair protein ERCC-5) (Xeroderma pigmentosum group G-complementing protein) ERCC5 ERCM2 XPG XPGC Homo sapiens (Human) 1186 "negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; response to UV [GO:0009411]; response to UV-C [GO:0010225]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]" GO:0000405; GO:0003690; GO:0003697; GO:0004520; GO:0005634; GO:0005654; GO:0006283; GO:0006293; GO:0006294; GO:0006295; GO:0006296; GO:0009411; GO:0009650; GO:0010225; GO:0033683; GO:0042803; GO:0043066; GO:0046872; GO:0047485 0 0 0 PF00867;PF00752; P46952 CHOYP_LOC582154.1.1 m.58922 sp 3HAO_HUMAN 53.191 282 126 3 52 333 10 285 2.42E-105 313 3HAO_HUMAN reviewed "3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) (3-hydroxyanthranilate oxygenase) (3-HAO) (3-hydroxyanthranilic acid dioxygenase) (HAD)" HAAO Homo sapiens (Human) 286 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; anthranilate metabolic process [GO:0043420]; neuron cellular homeostasis [GO:0070050]; quinolinate biosynthetic process [GO:0019805]; quinolinate metabolic process [GO:0046874]; response to cadmium ion [GO:0046686]; response to zinc ion [GO:0010043]; tryptophan catabolic process [GO:0006569] GO:0000334; GO:0005829; GO:0006569; GO:0008198; GO:0009055; GO:0010043; GO:0019805; GO:0034354; GO:0043420; GO:0046686; GO:0046874; GO:0070050; GO:0070062 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. {ECO:0000255|HAMAP-Rule:MF_03019}. 0 0 PF06052; P48166 CHOYP_RPL36A.1.1 m.24724 sp RL36A_CAEEL 78.302 106 22 1 15 120 1 105 2.42E-54 169 RL36A_CAEEL reviewed Ribosomal protein L36.A (60S ribosomal protein L44) (L41) rpl-36.A rpl-41 C09H10.2 Caenorhabditis elegans 105 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00935; P49069 CHOYP_CAMLG.1.1 m.18803 sp CAMLG_HUMAN 26.736 288 163 13 7 277 28 284 2.42E-10 63.5 CAMLG_HUMAN reviewed Calcium signal-modulating cyclophilin ligand (CAML) CAMLG CAML Homo sapiens (Human) 296 defense response [GO:0006952]; epidermal growth factor receptor signaling pathway [GO:0007173]; receptor recycling [GO:0001881]; signal transduction [GO:0007165]; viral process [GO:0016032] GO:0001881; GO:0005783; GO:0006952; GO:0007165; GO:0007173; GO:0016020; GO:0016021; GO:0016032 0 0 0 PF14963; P62278 CHOYP_RS13.2.5 m.20383 sp RS13_RAT 89.286 112 12 0 2 113 39 150 2.42E-71 212 RS13_RAT reviewed 40S ribosomal protein S13 Rps13 Rattus norvegicus (Rat) 151 translation [GO:0006412] GO:0003735; GO:0005730; GO:0006412; GO:0022627; GO:0070181; GO:1990932 0 0 cd00353; PF08069;PF00312; P80146 CHOYP_LOC576248.1.1 m.262 sp SEPR_THESR 46.015 389 180 7 22 385 24 407 2.42E-94 291 SEPR_THESR reviewed Extracellular serine proteinase (EC 3.4.21.-) 0 Thermus sp. (strain Rt41A) 410 0 GO:0004252; GO:0005576 0 0 0 PF05922;PF00082; Q05516 CHOYP_ZN572.1.1 m.12503 sp ZBT16_HUMAN 26.012 173 115 5 337 504 428 592 2.42E-08 61.6 ZBT16_HUMAN reviewed Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF) ZBTB16 PLZF ZNF145 Homo sapiens (Human) 673 "anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cartilage development [GO:0051216]; central nervous system development [GO:0007417]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic pattern specification [GO:0009880]; forelimb morphogenesis [GO:0035136]; hemopoiesis [GO:0030097]; male germ-line stem cell asymmetric division [GO:0048133]; mesonephros development [GO:0001823]; myeloid cell differentiation [GO:0030099]; negative regulation of cell proliferation [GO:0008285]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of ossification [GO:0045778]; positive regulation of transcription, DNA-templated [GO:0045893]; protein localization to nucleus [GO:0034504]; protein ubiquitination [GO:0016567]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000980; GO:0001206; GO:0001823; GO:0003677; GO:0005634; GO:0005730; GO:0005829; GO:0005886; GO:0006351; GO:0006915; GO:0007417; GO:0008285; GO:0009880; GO:0009952; GO:0016567; GO:0016604; GO:0016605; GO:0016607; GO:0017053; GO:0030097; GO:0030099; GO:0032332; GO:0034504; GO:0035116; GO:0035136; GO:0042733; GO:0042802; GO:0042803; GO:0043065; GO:0045600; GO:0045638; GO:0045778; GO:0045892; GO:0045893; GO:0046872; GO:0048133; GO:0051138; GO:0051216; GO:0061036 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00651;PF13912; Q06852 CHOYP_NEMVEDRAFT_V1G208691.5.10 m.23857 sp SLAP1_CLOTH 58.242 273 82 20 2 249 1437 1702 2.42E-15 79.7 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q06852 CHOYP_NEMVEDRAFT_V1G208691.7.10 m.41858 sp SLAP1_CLOTH 54.695 426 133 31 1008 1381 1499 1916 2.42E-30 135 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q07553 CHOYP_LOC100370187.1.1 m.8872 sp GCY3E_DROME 54.26 223 100 1 389 611 828 1048 2.42E-73 259 GCY3E_DROME reviewed Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) 1163 cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; signal transduction [GO:0007165] GO:0004383; GO:0004872; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007165; GO:0008074; GO:0019934 0 0 0 PF01094;PF00211;PF07714; Q09324 CHOYP_LOC100375210.1.3 m.3499 sp GCNT1_MOUSE 36.243 378 206 8 121 466 42 416 2.42E-68 228 GCNT1_MOUSE reviewed "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)" Gcnt1 Mus musculus (Mouse) 428 cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; protein glycosylation [GO:0006486]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729] GO:0000139; GO:0003829; GO:0005615; GO:0005802; GO:0006486; GO:0009101; GO:0016021; GO:0031985; GO:0032868; GO:0048729; GO:0050901; GO:0060352; GO:0060993 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02485; Q3U2J5 CHOYP_LOC100892187.1.1 m.12761 sp CMKMT_MOUSE 45.329 289 152 4 31 314 36 323 2.42E-88 270 CMKMT_MOUSE reviewed Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) Camkmt Clnmt Mus musculus (Mouse) 323 mitochondrion organization [GO:0007005]; peptidyl-lysine methylation [GO:0018022] GO:0005634; GO:0005794; GO:0007005; GO:0018022; GO:0018025 0 0 0 PF10294; Q4KLT0 CHOYP_RNF217.1.1 m.57306 sp RN217_XENLA 42.143 280 152 6 93 369 3 275 2.42E-66 221 RN217_XENLA reviewed Probable E3 ubiquitin-protein ligase RNF217 (EC 6.3.2.-) (RING finger protein 217) rnf217 Xenopus laevis (African clawed frog) 282 0 GO:0004842; GO:0016021; GO:0016874; GO:0046872 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; Q5BIM1 CHOYP_LOC100376215.19.19 m.53333 sp TRI45_BOVIN 24.686 239 142 11 4 209 127 360 2.42E-08 59.7 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5I0K7 CHOYP_BRAFLDRAFT_115464.1.2 m.22826 sp ALG13_RAT 55.782 147 60 3 21 164 5 149 2.42E-48 159 ALG13_RAT reviewed UDP-N-acetylglucosamine transferase subunit ALG13 homolog (EC 2.4.1.141) (Glycosyltransferase 28 domain-containing protein 1) Alg13 Glt28d1 Rattus norvegicus (Rat) 165 0 GO:0004577; GO:0005783 0 0 0 PF04101; Q5U538 CHOYP_LOC100569317.1.1 m.37609 sp HARB1_XENLA 32.039 103 68 1 37 137 39 141 2.42E-10 60.1 HARB1_XENLA reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 Xenopus laevis (African clawed frog) 347 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q5YCC5 CHOYP_TMC7.1.1 m.27541 sp TMC7_CHICK 36.082 97 58 1 81 177 618 710 2.42E-13 70.5 TMC7_CHICK reviewed Transmembrane channel-like protein 7 Tmc7 Gallus gallus (Chicken) 735 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q5ZIJ9 CHOYP_BRAFLDRAFT_120990.4.18 m.22274 sp MIB2_CHICK 35.065 77 43 1 654 723 9 85 2.42E-06 55.1 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6AYD3 CHOYP_LOC100370552.2.2 m.59438 sp PA2G4_RAT 61.773 361 136 2 22 381 5 364 2.42E-163 467 PA2G4_RAT reviewed Proliferation-associated protein 2G4 Pa2g4 Rattus norvegicus (Rat) 394 "negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005654; GO:0005730; GO:0005737; GO:0006351; GO:0006364; GO:0006417; GO:0016020; GO:0030529; GO:0043066; GO:0044822; GO:0045597; GO:0045892; GO:0070062 0 0 0 PF00557; Q6DEL1 CHOYP_S38A7.1.1 m.2800 sp S38A7_DANRE 42.857 441 235 6 9 443 28 457 2.42E-114 347 S38A7_DANRE reviewed Putative sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7) slc38a7 zgc:100802 Danio rerio (Zebrafish) (Brachydanio rerio) 465 asparagine transport [GO:0006867]; aspartate transport [GO:0015810]; L-alanine transport [GO:0015808]; L-serine transport [GO:0015825]; sodium ion transport [GO:0006814] GO:0005290; GO:0005313; GO:0006814; GO:0006867; GO:0015180; GO:0015182; GO:0015183; GO:0015186; GO:0015190; GO:0015191; GO:0015194; GO:0015808; GO:0015810; GO:0015825; GO:0016021 0 0 0 PF01490; Q6GMN2 CHOYP_BAIP2.1.1 m.5112 sp BAIP2_RAT 28.351 582 296 16 1 513 3 532 2.42E-57 202 BAIP2_RAT reviewed Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53) Baiap2 Rattus norvegicus (Rat) 535 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; dendrite development [GO:0016358]; insulin receptor signaling pathway [GO:0008286]; plasma membrane organization [GO:0007009]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of synaptic plasticity [GO:0048167]; response to bacterium [GO:0009617] GO:0001726; GO:0005829; GO:0005886; GO:0007009; GO:0008093; GO:0008286; GO:0008360; GO:0009617; GO:0014069; GO:0015629; GO:0016358; GO:0030141; GO:0030165; GO:0030175; GO:0030838; GO:0032956; GO:0043025; GO:0043197; GO:0048167; GO:0051017; GO:0051764; GO:0061003; GO:0070062; GO:0070064; GO:2000251 0 0 0 PF08397;PF14604; Q6R7G8 CHOYP_BRAFLDRAFT_63291.1.1 m.18888 sp Y057_OSHVF 23.684 152 113 1 170 318 117 268 2.42E-10 64.3 Y057_OSHVF reviewed Putative transmembrane protein ORF57 ORF57 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 316 0 GO:0016021; GO:0033644 0 0 0 PF05934; Q8BV79 CHOYP_LOC100513756.1.1 m.54304 sp TRNK1_MOUSE 23.063 555 348 22 43 548 2291 2815 2.42E-14 81.3 TRNK1_MOUSE reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1) Trank1 Gm187 Kiaa0342 Lba1 Mus musculus (Mouse) 2999 0 0 0 0 0 0 Q8C0D5 CHOYP_ND4.1.5 m.1954 sp EFL1_MOUSE 56.725 171 67 1 21 184 925 1095 2.42E-58 200 EFL1_MOUSE reviewed Elongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A) Efl1 Eftud1 Mus musculus (Mouse) 1127 mature ribosome assembly [GO:0042256] GO:0003924; GO:0005525; GO:0005622; GO:0042256; GO:0043022 0 0 0 PF00679;PF14492; Q8IZJ3 CHOYP_LOC100372598.1.2 m.5543 sp CPMD8_HUMAN 31.507 146 94 4 89 233 951 1091 2.42E-14 77.4 CPMD8_HUMAN reviewed C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) 1885 0 GO:0004867; GO:0005615; GO:0005886 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF07648;PF12248;PF10569; Q8N6F8 CHOYP_BRAFLDRAFT_126943.2.3 m.13518 sp WBS27_HUMAN 31.633 196 128 5 46 238 1 193 2.42E-27 108 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q8NBN7 CHOYP_LOC100699974.1.1 m.56493 sp RDH13_HUMAN 55.591 313 134 3 61 372 11 319 2.42E-109 326 RDH13_HUMAN reviewed Retinol dehydrogenase 13 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 7C member 3) RDH13 SDR7C3 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) 331 eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842] GO:0005743; GO:0009644; GO:0010842; GO:0016491; GO:0042462; GO:0052650 0 0 0 PF00106; Q8UUG8 CHOYP_BRS3.1.1 m.23411 sp 5HT2B_TETFL 24.457 368 251 14 27 375 26 385 2.42E-09 62.4 5HT2B_TETFL reviewed 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) htr2b Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) 471 behavior [GO:0007610]; embryonic morphogenesis [GO:0048598]; heart development [GO:0007507]; regulation of behavior [GO:0050795]; serotonin uptake [GO:0051610]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310] GO:0001587; GO:0005887; GO:0006939; GO:0007507; GO:0007610; GO:0030054; GO:0030285; GO:0030594; GO:0042310; GO:0043005; GO:0048598; GO:0050795; GO:0051610 0 0 0 PF00001; Q8VI56 CHOYP_LOC578599.3.8 m.22632 sp LRP4_MOUSE 26.644 867 574 28 121 957 514 1348 2.42E-80 293 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q96RU3 CHOYP_LOC100122293.2.2 m.61265 sp FNBP1_HUMAN 36.635 636 317 8 1 579 1 607 2.42E-129 395 FNBP1_HUMAN reviewed Formin-binding protein 1 (Formin-binding protein 17) (hFBP17) FNBP1 FBP17 KIAA0554 Homo sapiens (Human) 617 endocytosis [GO:0006897]; vesicle-mediated transport [GO:0016192] GO:0005086; GO:0005764; GO:0005802; GO:0005856; GO:0005886; GO:0005905; GO:0005938; GO:0006897; GO:0008289; GO:0016023; GO:0016192; GO:0042802 0 0 0 PF00611;PF14604; Q96RW7 CHOYP_BRAFLDRAFT_68242.2.3 m.26345 sp HMCN1_HUMAN 41.156 294 169 4 26 318 4524 4814 2.42E-70 257 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9C040 CHOYP_BRAFLDRAFT_73101.1.4 m.3240 sp TRIM2_HUMAN 24.757 206 137 6 125 326 516 707 2.42E-07 55.8 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9D5I4 CHOYP_TCTEX1D1.2.2 m.58260 sp TC1D1_MOUSE 33.058 121 79 1 94 214 55 173 2.42E-17 79.3 TC1D1_MOUSE reviewed Tctex1 domain-containing protein 1 Tctex1d1 Mus musculus (Mouse) 173 0 0 0 0 0 PF03645; Q9UBI4 CHOYP_NEMVEDRAFT_V1G209966.1.1 m.26142 sp STML1_HUMAN 32.479 351 224 4 74 420 54 395 2.42E-61 207 STML1_HUMAN reviewed Stomatin-like protein 1 (SLP-1) (EPB72-like protein 1) (Protein unc-24 homolog) (Stomatin-related protein) (STORP) STOML1 SLP1 UNC24 MSTP019 Homo sapiens (Human) 398 0 GO:0016021 0 0 0 PF01145;PF02036; Q9W141 CHOYP_ISCW_ISCW016254.1.5 m.37315 sp ATPK_DROME 31.429 105 72 0 28 132 3 107 2.42E-13 64.7 ATPK_DROME reviewed "Putative ATP synthase subunit f, mitochondrial" CG4692 Drosophila melanogaster (Fruit fly) 107 ATP biosynthetic process [GO:0006754]; lateral inhibition [GO:0046331]; proton transport [GO:0015992] GO:0005739; GO:0005811; GO:0006754; GO:0015992; GO:0031966; GO:0045263; GO:0046331 0 0 0 PF10206; Q9ZQ47 CHOYP_LOC100367312.8.13 m.38496 sp GRDP1_ARATH 40.244 246 138 5 1 237 48 293 2.42E-50 191 GRDP1_ARATH reviewed Glycine-rich domain-containing protein 1 (AtGRDP1) GRDP1 At2g22660 T9I22.10 Arabidopsis thaliana (Mouse-ear cress) 819 abscisic acid-activated signaling pathway [GO:0009738]; cellular response to osmotic stress [GO:0071470]; regulation of abscisic acid-activated signaling pathway [GO:0009787]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650] GO:0005198; GO:0005886; GO:0006979; GO:0009650; GO:0009738; GO:0009787; GO:0071470 0 0 0 PF07173; A2AL36 CHOYP_CNTRL.1.1 m.8381 sp CNTRL_MOUSE 30.615 1349 742 35 77 1342 76 1313 2.43E-135 479 CNTRL_MOUSE reviewed Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) Cntrl Cep1 Cep110 Mus musculus (Mouse) 2334 aorta development [GO:0035904]; cardiac septum development [GO:0003279]; cell division [GO:0051301]; coronary vasculature development [GO:0060976]; mitotic cell cycle [GO:0000278]; ventricular septum development [GO:0003281] GO:0000278; GO:0003279; GO:0003281; GO:0005737; GO:0005813; GO:0016020; GO:0035904; GO:0048471; GO:0051301; GO:0060976; GO:0097431 0 0 0 0 A4IF63 CHOYP_LOC100376214.11.11 m.57760 sp TRIM2_BOVIN 29.167 144 98 3 695 835 602 744 2.43E-08 62 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O01814 CHOYP_FABPL.1.1 m.22046 sp FABP5_CAEEL 32.52 123 82 1 7 128 5 127 2.43E-13 65.9 FABP5_CAEEL reviewed Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans 136 0 GO:0005215; GO:0005504; GO:0005634; GO:0048471 0 0 0 PF00061; O57382 CHOYP_BRAFLDRAFT_66659.1.2 m.2455 sp TLL2_XENLA 36.111 72 45 1 3 73 195 266 2.43E-06 47.8 TLL2_XENLA reviewed Tolloid-like protein 2 (EC 3.4.24.-) (Metalloprotease xolloid) (Xenopus tolloid) tll2 xld Xenopus laevis (African clawed frog) 1019 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0004222; GO:0005509; GO:0005576; GO:0007275; GO:0008270; GO:0030154 0 0 0 PF01400;PF00431;PF00008; O70277 CHOYP_BRAFLDRAFT_85511.20.23 m.60524 sp TRIM3_RAT 25.103 243 148 10 325 554 523 744 2.43E-09 63.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P20480 CHOYP_KIF2.2.2 m.57868 sp NCD_DROME 41.892 370 185 9 266 621 315 668 2.43E-72 249 NCD_DROME reviewed Protein claret segregational ncd CA(ND) CG7831 Drosophila melanogaster (Fruit fly) 700 cell division [GO:0051301]; centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; chromosome segregation [GO:0007059]; distributive segregation [GO:0032837]; meiotic spindle organization [GO:0000212]; microtubule-based movement [GO:0007018]; microtubule bundle formation [GO:0001578]; minus-end directed microtubule sliding [GO:0031534]; mitotic centrosome separation [GO:0007100]; mitotic spindle assembly [GO:0090307]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; regulation of mitotic spindle assembly [GO:1901673]; regulation of mitotic spindle elongation [GO:0032888]; spindle assembly involved in female meiosis [GO:0007056]; spindle assembly involved in meiosis [GO:0090306]; spindle organization [GO:0007051] GO:0000022; GO:0000212; GO:0001578; GO:0003777; GO:0005524; GO:0005634; GO:0005813; GO:0005819; GO:0005829; GO:0005871; GO:0007018; GO:0007051; GO:0007052; GO:0007056; GO:0007059; GO:0007100; GO:0008569; GO:0016887; GO:0031534; GO:0032837; GO:0032888; GO:0042803; GO:0051028; GO:0051297; GO:0051298; GO:0051301; GO:0072687; GO:0090306; GO:0090307; GO:1901673; GO:1990498 0 0 0 PF00225; P24081 CHOYP_LOC100889156.5.10 m.22696 sp AN_NPVOP 25.551 227 134 9 39 243 36 249 2.43E-07 55.1 AN_NPVOP reviewed Alkaline nuclease (AN) (EC 3.1.-.-) ALK-EXO ORF131 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) 424 0 GO:0003677; GO:0004519; GO:0004527; GO:0042025 0 0 0 PF01771; P28828 CHOYP_PTPRT.39.45 m.60308 sp PTPRM_MOUSE 39.383 551 322 7 741 1282 903 1450 2.43E-122 417 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P33174 CHOYP_LOC576465.1.1 m.55907 sp KIF4_MOUSE 35.549 346 199 6 5 330 8 349 2.43E-57 214 KIF4_MOUSE reviewed Chromosome-associated kinesin KIF4 (Chromokinesin) Kif4 Kif4a Kns4 Mus musculus (Mouse) 1231 microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256] GO:0000281; GO:0003677; GO:0005524; GO:0005654; GO:0005694; GO:0005829; GO:0005871; GO:0005874; GO:0007018; GO:0008574; GO:0016020; GO:0030496; GO:0051256 0 0 0 PF00225; P50464 CHOYP_LOC100123629.1.1 m.841 sp UNC97_CAEEL 62.147 354 119 4 32 380 1 344 2.43E-165 469 UNC97_CAEEL reviewed LIM domain-containing protein unc-97 (PINCH homolog) (Uncoordinated protein 97) unc-97 F14D12.2 Caenorhabditis elegans 348 cell-cell junction organization [GO:0045216]; muscle organ development [GO:0007517]; sensory perception of mechanical stimulus [GO:0050954] GO:0005634; GO:0005654; GO:0005912; GO:0007517; GO:0008270; GO:0009925; GO:0017022; GO:0031430; GO:0045216; GO:0050954; GO:0055120 0 0 0 PF00412; P86397 CHOYP_LOC754233.1.1 m.1209 sp HTD2_HUMAN 42.963 135 77 0 29 163 32 166 2.43E-36 126 HTD2_HUMAN reviewed "Hydroxyacyl-thioester dehydratase type 2, mitochondrial (HsHTD2) (EC 4.2.1.-) (3-hydroxyacyl-[acyl-carrier-protein] dehydratase)" RPP14 Homo sapiens (Human) 168 fatty acid metabolic process [GO:0006631] GO:0005730; GO:0005737; GO:0005739; GO:0006631; GO:0016829 0 0 0 PF01575; Q01528 CHOYP_HAAF.11.13 m.44366 sp HAAF_LIMPO 42.197 173 95 3 55 226 1 169 2.43E-40 139 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q13889 CHOYP_TF2H3.1.1 m.11146 sp TF2H3_HUMAN 41.221 131 65 5 1 124 19 144 2.43E-21 90.9 TF2H3_HUMAN reviewed General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit) GTF2H3 Homo sapiens (Human) 308 "7-methylguanosine mRNA capping [GO:0006370]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; phosphorylation of RNA polymerase II C-terminal domain [GO:0070816]; termination of RNA polymerase I transcription [GO:0006363]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription initiation from RNA polymerase I promoter [GO:0006361]" GO:0000439; GO:0000717; GO:0003684; GO:0003700; GO:0005654; GO:0005675; GO:0006281; GO:0006283; GO:0006289; GO:0006293; GO:0006294; GO:0006295; GO:0006296; GO:0006361; GO:0006362; GO:0006363; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0008135; GO:0033683; GO:0046872; GO:0047485; GO:0070816; GO:0070911 0 0 0 PF03850; Q14162 CHOYP_NEMVEDRAFT_V1G188423.1.1 m.44093 sp SREC_HUMAN 32.895 228 124 13 37 249 125 338 2.43E-15 81.6 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q1MSJ5 CHOYP_CSPP1.7.14 m.39994 sp CSPP1_HUMAN 30.353 1163 587 42 410 1410 124 1225 2.43E-54 212 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q25379 CHOYP_ACT1.1.7 m.18260 sp ACT3_LYTPI 83.019 106 18 0 1 106 24 129 2.43E-57 178 ACT3_LYTPI reviewed "Actin, cytoskeletal 3 (LPC3) (Fragment)" 0 Lytechinus pictus (Painted sea urchin) 172 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q2FXL6 CHOYP_NEMVEDRAFT_V1G242153.4.4 m.60071 sp Y1819_STAA8 31.818 154 85 5 12 160 5 143 2.43E-11 61.6 Y1819_STAA8 reviewed Putative universal stress protein SAOUHSC_01819 SAOUHSC_01819 Staphylococcus aureus (strain NCTC 8325) 166 response to stress [GO:0006950] GO:0005737; GO:0006950 0 0 0 PF00582; Q2YDJ8 CHOYP_contig_003237 m.3618 sp KMT5A_BOVIN 32.54 126 66 4 54 162 226 349 2.43E-14 73.2 KMT5A_BOVIN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A SETD8 Bos taurus (Bovine) 352 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0005634; GO:0005694; GO:0006351; GO:0007067; GO:0016279; GO:0018024; GO:0018026; GO:0043516; GO:0051301 0 0 0 PF00856; Q3UH93 CHOYP_PLXD1.1.1 m.19643 sp PLXD1_MOUSE 30.645 248 145 9 3 244 903 1129 2.43E-18 87.8 PLXD1_MOUSE reviewed Plexin-D1 Plxnd1 Mus musculus (Mouse) 1925 angiogenesis [GO:0001525]; aorta development [GO:0035904]; branchiomotor neuron axon guidance [GO:0021785]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; dichotomous subdivision of terminal units involved in salivary gland branching [GO:0060666]; endothelial cell migration [GO:0043542]; outflow tract morphogenesis [GO:0003151]; patterning of blood vessels [GO:0001569]; positive regulation of protein binding [GO:0032092]; regulation of angiogenesis [GO:0045765]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; synapse assembly [GO:0007416] GO:0001525; GO:0001569; GO:0002116; GO:0003151; GO:0003279; GO:0005886; GO:0005887; GO:0007416; GO:0017154; GO:0019904; GO:0021785; GO:0030027; GO:0030334; GO:0032092; GO:0035904; GO:0043542; GO:0045765; GO:0048841; GO:0060666; GO:0060976; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q4UMH6 CHOYP_AASI_1435.18.35 m.41280 sp Y381_RICFE 32.287 223 146 2 95 317 900 1117 2.43E-28 120 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q4UMH6 CHOYP_LOC755594.2.6 m.51265 sp Y381_RICFE 27.541 305 208 6 1035 1338 683 975 2.43E-23 111 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q502K3 CHOYP_LOC578974.1.11 m.4371 sp ANR52_DANRE 29.948 965 573 16 4 870 33 992 2.43E-112 372 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q5E9E1 CHOYP_PDLI1.2.2 m.2094 sp PDLI1_BOVIN 35.882 340 156 8 11 313 3 317 2.43E-54 183 PDLI1_BOVIN reviewed PDZ and LIM domain protein 1 (Elfin) PDLIM1 Bos taurus (Bovine) 328 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003713; GO:0005667; GO:0005737; GO:0005856; GO:0006355; GO:0008270 0 0 0 PF15936;PF00412;PF00595; Q5TZ24 CHOYP_LOC100179142.1.1 m.26402 sp MOXD1_DANRE 39.915 471 270 8 10 477 26 486 2.43E-114 355 MOXD1_DANRE reviewed DBH-like monooxygenase protein 1 homolog (EC 1.14.17.-) moxd1 si:ch211-193l17.1 si:dkey-266k12.5 si:dkeyp-119b4.5 Danio rerio (Zebrafish) (Brachydanio rerio) 614 0 GO:0005507; GO:0005789; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q62638 CHOYP_GSLG1.1.3 m.31146 sp GSLG1_RAT 44.581 406 211 5 2 406 304 696 2.43E-122 384 GSLG1_RAT reviewed Golgi apparatus protein 1 (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) Glg1 Esl1 Mg160 Rattus norvegicus (Rat) 1171 intracellular protein transport [GO:0006886] GO:0000139; GO:0005797; GO:0006886; GO:0016021; GO:0017134; GO:0043231 0 0 0 PF00839; Q642H2 CHOYP_DMOJ_GI18265.1.1 m.36511 sp CRBL2_DANRE 48.438 64 31 1 4 67 10 71 2.43E-13 63.9 CRBL2_DANRE reviewed cAMP-responsive element-binding protein-like 2 crebl2 zgc:92620 Danio rerio (Zebrafish) (Brachydanio rerio) 119 "cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0030154; GO:0043565; GO:0045600; GO:0045893; GO:0046326; GO:0046889 0 0 0 PF07716; Q6P9Z4 CHOYP_LOC655478.1.1 m.25203 sp FEM1A_DANRE 26.712 584 388 18 69 631 53 617 2.43E-48 182 FEM1A_DANRE reviewed Protein fem-1 homolog A (FEM1a) (FEM1-alpha) fem1a zgc:63483 Danio rerio (Zebrafish) (Brachydanio rerio) 617 regulation of ubiquitin-protein transferase activity [GO:0051438] GO:0004842; GO:0005737; GO:0051438 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q8BYF6 CHOYP_BRAFLDRAFT_213839.1.2 m.25606 sp SC5A8_MOUSE 43.038 553 297 9 7 546 9 556 2.43E-151 454 SC5A8_MOUSE reviewed Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (Solute carrier family 5 member 8) Slc5a8 Smct Smct1 Mus musculus (Mouse) 611 apoptotic process [GO:0006915]; sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0006915; GO:0015293; GO:0016324; GO:0070062 0 0 0 PF00474; Q8CFF0 CHOYP_NAEGRDRAFT_81435.1.2 m.22968 sp PAR11_MOUSE 29.386 228 97 8 1 207 144 328 2.43E-18 84.7 PAR11_MOUSE reviewed Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) Parp11 Mus musculus (Mouse) 331 cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; nuclear envelope organization [GO:0006998]; protein transport [GO:0015031]; spermatogenesis [GO:0007283] GO:0003950; GO:0005635; GO:0005643; GO:0006998; GO:0007283; GO:0015031; GO:0030154; GO:0051028 0 0 0 PF00644;PF02825; Q8K0U4 CHOYP_NEMVEDRAFT_V1G212312.2.5 m.45586 sp HS12A_MOUSE 30.376 665 387 17 711 1303 13 673 2.43E-80 282 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q99M80 CHOYP_MEGF11.4.11 m.34637 sp PTPRT_MOUSE 31.876 709 430 17 781 1449 758 1453 2.43E-84 308 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9NXB0 CHOYP_LOC100220405.1.1 m.50564 sp MKS1_HUMAN 46.923 130 69 0 1 130 425 554 2.43E-32 122 MKS1_HUMAN reviewed Meckel syndrome type 1 protein MKS1 Homo sapiens (Human) 559 "branching morphogenesis of an epithelial tube [GO:0048754]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; common bile duct development [GO:0061009]; determination of left/right symmetry [GO:0007368]; embryonic brain development [GO:1990403]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial structure maintenance [GO:0010669]; head development [GO:0060322]; inner ear receptor stereocilium organization [GO:0060122]; motile primary cilium assembly [GO:1903887]; neural tube closure [GO:0001843]; nonmotile primary cilium assembly [GO:0035058]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901620]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]" GO:0001843; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0007368; GO:0010669; GO:0016020; GO:0035058; GO:0036038; GO:0036064; GO:0042384; GO:0042733; GO:0048706; GO:0048754; GO:0060122; GO:0060271; GO:0060322; GO:0060828; GO:0061009; GO:1901620; GO:1903887; GO:1990403; GO:2000095 0 0 0 PF07162; Q9UGU5 CHOYP_HMGXB4.1.2 m.26633 sp HMGX4_HUMAN 65.934 91 31 0 65 155 511 601 2.43E-34 129 HMGX4_HUMAN reviewed HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) HMGXB4 HMG2L1 HMGBCG Homo sapiens (Human) 601 endosome to lysosome transport [GO:0008333]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0003677; GO:0008333; GO:0016055; GO:0016589; GO:0030178 0 0 0 PF13775;PF00505; Q9VVE5 CHOYP_MSI2H.1.3 m.7627 sp MSIR6_DROME 53.05 377 117 9 19 387 23 347 2.43E-116 347 MSIR6_DROME reviewed RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) 369 stem cell development [GO:0048864] GO:0000166; GO:0003727; GO:0005737; GO:0005844; GO:0008266; GO:0048864 0 0 0 PF00076; Q9WTS8 CHOYP_BRAFLDRAFT_205632.1.1 m.58150 sp FCN1_RAT 43.709 151 78 3 1 150 161 305 2.43E-29 113 FCN1_RAT reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Rattus norvegicus (Rat) 335 cell surface pattern recognition receptor signaling pathway [GO:0002752]; G-protein coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; positive regulation of interleukin-8 secretion [GO:2000484] GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0045087; GO:0046872; GO:2000484 0 0 0 PF01391;PF00147; Q9ZPX1 CHOYP_LOC100373889.2.4 m.30220 sp ARF5_ARATH 35.152 165 99 4 68 232 17 173 2.43E-25 101 ARF5_ARATH reviewed ADP-ribosylation factor-like protein 2 (Protein ARF-like 2) (Protein HALLIMASCH) (Protein TITAN 5) ARL2 HAL TTN5 At2g18390 T30D6.10 Arabidopsis thaliana (Mouse-ear cress) 185 embryo development ending in seed dormancy [GO:0009793]; embryo sac cellularization [GO:0009558]; endosperm development [GO:0009960]; small GTPase mediated signal transduction [GO:0007264]; tubulin complex assembly [GO:0007021] GO:0005525; GO:0005737; GO:0007021; GO:0007264; GO:0009558; GO:0009793; GO:0009960 0 0 0 PF00025; A6QQ68 CHOYP_LOC100372845.3.3 m.48863 sp F228B_BOVIN 29.004 231 151 4 74 298 20 243 2.44E-26 109 F228B_BOVIN reviewed Protein FAM228B FAM228B Bos taurus (Bovine) 264 0 0 0 0 0 0 B0JZG0 CHOYP_LOC100486632.2.2 m.58610 sp S23A2_XENTR 43.609 532 289 5 5 529 112 639 2.44E-157 466 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; C0HBB2 CHOYP_BRAFLDRAFT_85896.1.1 m.38692 sp GLMP_SALSA 29.016 386 250 12 64 445 30 395 2.44E-48 174 GLMP_SALSA reviewed Glycosylated lysosomal membrane protein (Lysosomal protein NCU-G1) glmp Salmo salar (Atlantic salmon) 406 0 GO:0005764; GO:0005765; GO:0016021 0 0 0 PF15065; D3KCC4 CHOYP_CP2CN.1.1 m.20208 sp CRNS1_CHICK 29.693 522 330 12 35 532 48 556 2.44E-50 189 CRNS1_CHICK reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 Gallus gallus (Chicken) 930 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 O42387 CHOYP_RPS24.5.8 m.21704 sp RS24_TAKRU 80.315 127 25 0 42 168 4 130 2.44E-71 214 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O43808 CHOYP_PM34.1.1 m.11704 sp PM34_HUMAN 51.299 308 137 5 17 317 1 302 2.44E-100 300 PM34_HUMAN reviewed Peroxisomal membrane protein PMP34 (34 kDa peroxisomal membrane protein) (Solute carrier family 25 member 17) SLC25A17 PMP34 Homo sapiens (Human) 307 ATP transport [GO:0015867]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; fatty acid transport [GO:0015908]; translation [GO:0006412] GO:0000295; GO:0001561; GO:0003735; GO:0005347; GO:0005739; GO:0005777; GO:0005778; GO:0005779; GO:0006412; GO:0006635; GO:0015217; GO:0015228; GO:0015230; GO:0015867; GO:0015908; GO:0016020; GO:0043231; GO:0044610; GO:0051087; GO:0051724; GO:0080122 0 0 0 PF00153; O75382 CHOYP_BRAFLDRAFT_213581.2.2 m.47118 sp TRIM3_HUMAN 26.852 108 77 1 168 275 622 727 2.44E-06 52.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02594 CHOYP_LOC659206.1.6 m.3537 sp CALM_ELEEL 95.455 88 4 0 1 88 27 114 2.44E-57 177 CALM_ELEEL reviewed Calmodulin (CaM) calm Electrophorus electricus (Electric eel) (Gymnotus electricus) 149 0 GO:0005509 0 0 0 PF13499; P18503 CHOYP_BRAFLDRAFT_76550.7.21 m.48034 sp CAS4_EPHMU 31.746 126 72 3 60 185 202 313 2.44E-06 51.2 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P48809 CHOYP_AAEL_AAEL008257.2.3 m.36861 sp RB27C_DROME 49.2 250 102 5 12 254 1 232 2.44E-69 231 RB27C_DROME reviewed Heterogeneous nuclear ribonucleoprotein 27C (Hrb27-C) (HRP48.1) (hnRNP 48) Hrb27C hrp48 Rbp7 CG10377 Drosophila melanogaster (Fruit fly) 421 "axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; lateral inhibition [GO:0046331]; negative regulation of oskar mRNA translation [GO:0007319]; pole plasm oskar mRNA localization [GO:0045451]; positive regulation of translation [GO:0045727]; regulation of mRNA splicing, via spliceosome [GO:0048024]" GO:0000166; GO:0003697; GO:0003729; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0007298; GO:0007319; GO:0007411; GO:0030529; GO:0043186; GO:0043234; GO:0045451; GO:0045727; GO:0046331; GO:0048024; GO:0048027 0 0 0 PF00076; P59722 CHOYP_LOC100377307.1.1 m.7485 sp EGLN1_RAT 46.93 228 111 4 140 367 112 329 2.44E-68 223 EGLN1_RAT reviewed Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (Fragment) Egln1 Rattus norvegicus (Rat) 338 negative regulation of CAMKK-AMPK signaling cascade [GO:1905290]; negative regulation of cAMP catabolic process [GO:0030821]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron death [GO:1901216]; regulation of angiogenesis [GO:0045765]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731] GO:0001666; GO:0005506; GO:0005634; GO:0005829; GO:0019899; GO:0030821; GO:0031418; GO:0031543; GO:0043065; GO:0043433; GO:0045765; GO:0051344; GO:0071731; GO:1901216; GO:1905290 0 0 0 PF13640; P81908 CHOYP_ISCW_ISCW012339.1.1 m.7476 sp CHLE_HORSE 39.68 562 309 10 21 570 3 546 2.44E-136 412 CHLE_HORSE reviewed Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (EQ-BCHE) (Pseudocholinesterase) BCHE Equus caballus (Horse) 574 0 GO:0003990; GO:0004104; GO:0005615; GO:0052689 0 0 0 PF08674;PF00135; P86854 CHOYP_PLC.3.5 m.7658 sp PLCL_MYTGA 29.87 154 98 2 7 159 12 156 2.44E-24 95.9 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q071E0 CHOYP_LOC100892236.7.7 m.58417 sp KT5AA_DANRE 38.129 139 76 4 43 172 207 344 2.44E-18 85.5 KT5AA_DANRE reviewed N-lysine methyltransferase KMT5A-A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A-A) (EC 2.1.1.43) (Lysine-specific methylase 5A-A) (SET domain-containing protein 8-A) kmt5aa set8a setd8 setd8a zgc:153719 Danio rerio (Zebrafish) (Brachydanio rerio) 344 "cell division [GO:0051301]; dorsal/ventral pattern formation [GO:0009953]; mitotic nuclear division [GO:0007067]; positive regulation of gene expression [GO:0010628]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007067; GO:0009953; GO:0010628; GO:0018024; GO:0051301 0 0 0 PF00856; Q09003 CHOYP_COIL.1.1 m.18070 sp COIL_XENLA 24.952 525 303 19 4 457 1 505 2.44E-22 103 COIL_XENLA reviewed Coilin (Sphere organelles protein SPH-1) (Sphere protein 1) coil sph1 Xenopus laevis (African clawed frog) 536 0 GO:0071601 0 0 0 PF15862; Q12955 CHOYP_BRAFLDRAFT_100807.1.1 m.50437 sp ANK3_HUMAN 32.026 153 96 3 113 265 48 192 2.44E-15 80.5 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q24799 CHOYP_ISCW_ISCW021202.1.2 m.11949 sp MYPH_ECHGR 42.458 179 90 3 38 208 17 190 2.44E-37 131 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q28824 CHOYP_TITIN.19.19 m.66289 sp MYLK_BOVIN 37.045 880 452 15 817 1669 355 1159 2.44E-176 566 MYLK_BOVIN reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK Bos taurus (Bovine) 1176 positive regulation of cell migration [GO:0030335]; smooth muscle contraction [GO:0006939] GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0006939; GO:0030027; GO:0030335; GO:0032154; GO:0046872 0 0 0 PF00041;PF07679;PF00069; Q29548 CHOYP_LOC664571.1.1 m.52989 sp HEXB_PIG 40.481 499 246 12 92 576 67 528 2.44E-118 365 HEXB_PIG reviewed Beta-hexosaminidase subunit beta (EC 3.2.1.52) (65 kDa epididymal boar protein) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (N-acetyl-beta-glucosaminidase subunit beta) HEXB Sus scrofa (Pig) 531 carbohydrate metabolic process [GO:0005975] GO:0004563; GO:0005764; GO:0005975 0 0 0 PF00728;PF14845; Q2IBG7 CHOYP_MET.2.2 m.54710 sp MET_EULMM 28.835 1356 770 52 45 1280 63 1343 2.44E-129 436 MET_EULMM reviewed Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Eulemur macaco macaco (Black lemur) 1382 positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; semaphorin-plexin signaling pathway [GO:0071526]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0016021; GO:0050918; GO:0071526; GO:2001028 0 0 0 PF07714;PF01403;PF01833; Q2T9Z6 CHOYP_LOC577287.1.2 m.26577 sp CC175_BOVIN 22.171 654 461 11 13 642 46 675 2.44E-09 64.7 CC175_BOVIN reviewed Coiled-coil domain-containing protein 175 CCDC175 Bos taurus (Bovine) 724 0 0 0 0 0 0 Q3UHU5 CHOYP_PHUM_PHUM454570.1.1 m.28665 sp MTCL1_MOUSE 32.641 337 171 8 512 845 337 620 2.44E-28 129 MTCL1_MOUSE reviewed Microtubule cross-linking factor 1 (Coiled-coil domain-containing protein 165) (PAR-1-interacting protein) (SOGA family member 2) Mtcl1 Ccdc165 Kiaa0802 Soga2 Mus musculus (Mouse) 1945 establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; microtubule bundle formation [GO:0001578]; positive regulation of microtubule motor activity [GO:2000576]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of autophagy [GO:0010506] GO:0000922; GO:0001578; GO:0005615; GO:0005737; GO:0005856; GO:0008017; GO:0010506; GO:0016324; GO:0016327; GO:0016328; GO:0030496; GO:0042803; GO:0044822; GO:0045197; GO:0090314; GO:0097427; GO:2000576 0 0 0 PF14818;PF11365; Q3ZBR5 CHOYP_TTC1.1.2 m.53162 sp TTC1_BOVIN 48.148 270 121 2 4 254 22 291 2.44E-79 243 TTC1_BOVIN reviewed Tetratricopeptide repeat protein 1 (TPR repeat protein 1) TTC1 Bos taurus (Bovine) 292 0 GO:0005778 0 0 0 PF00515; Q4R4Z9 CHOYP_THERJR_2510.1.1 m.38407 sp ACSF2_MACFA 24.329 559 361 22 21 549 76 602 2.44E-32 135 ACSF2_MACFA reviewed "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" ACSF2 QnpA-14939 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 618 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005739; GO:0006631; GO:0016874 0 0 0 PF00501;PF13193; Q4R744 CHOYP_LOC753178.2.2 m.60569 sp HEAT9_MACFA 28.44 327 222 7 767 1088 142 461 2.44E-26 119 HEAT9_MACFA reviewed Protein HEATR9 (HEAT repeat-containing protein 9) HEATR9 QtsA-16377 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 570 0 0 0 0 0 0 Q502K3 CHOYP_AFUA_1G01020.23.50 m.32933 sp ANR52_DANRE 33.555 301 185 3 1 286 64 364 2.44E-43 161 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q5I0P2 CHOYP_CPIPJ_CPIJ016638.1.1 m.25816 sp GCSH_RAT 58.974 117 48 0 29 145 36 152 2.44E-43 144 GCSH_RAT reviewed "Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)" Gcsh Rattus norvegicus (Rat) 170 glycine decarboxylation via glycine cleavage system [GO:0019464] GO:0004047; GO:0005739; GO:0005960; GO:0019464; GO:0019899 0 0 cd06848; 0 Q5RC07 CHOYP_LOC100744369.1.1 m.56679 sp ES8L2_PONAB 32.673 101 60 2 9 102 457 556 2.44E-10 59.3 ES8L2_PONAB reviewed Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2) EPS8L2 EPS8R2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 716 0 GO:0005737 0 0 0 PF08416;PF00018; Q5SNQ7 CHOYP_LOC100545103.1.1 m.40160 sp SRAC1_DANRE 45.785 522 273 5 72 589 137 652 2.44E-154 461 SRAC1_DANRE reviewed Protein SERAC1 (Serine active site-containing protein 1) serac1 Danio rerio (Zebrafish) (Brachydanio rerio) 658 phospholipid biosynthetic process [GO:0008654] GO:0005739; GO:0005783; GO:0008654; GO:0016021 0 0 0 0 Q66JA6 CHOYP_CAB45.1.1 m.64493 sp CAB45_XENLA 40.118 339 192 5 15 345 23 358 2.44E-70 226 CAB45_XENLA reviewed 45 kDa calcium-binding protein (Cab45) (Stromal cell-derived factor 4) (SDF-4) sdf4 cab45 Xenopus laevis (African clawed frog) 360 0 GO:0005509; GO:0005796 0 0 0 PF13202;PF13499; Q719N3 CHOYP_LOC659403.1.1 m.8243 sp PAQRB_RAT 44.978 229 125 1 13 240 7 235 2.44E-61 195 PAQRB_RAT reviewed Monocyte to macrophage differentiation factor (Macrophage/microglia activation-associated factor) (MAF) (Progestin and adipoQ receptor family member XI) Mmd Maf Paqr11 Rattus norvegicus (Rat) 238 cytolysis [GO:0019835]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase activity [GO:0045860]; regulation of protein localization [GO:0032880] GO:0004672; GO:0005765; GO:0005794; GO:0016021; GO:0019835; GO:0031902; GO:0032880; GO:0045666; GO:0045860 0 0 0 PF03006; Q7TNS2 CHOYP_BRAFLDRAFT_283990.4.4 m.46989 sp MIC10_MOUSE 58.065 62 26 0 23 84 2 63 2.44E-20 80.5 MIC10_MOUSE reviewed MICOS complex subunit Mic10 (Mitochondrial inner membrane organizing system protein 1) Minos1 Mic10 Mus musculus (Mouse) 76 0 GO:0005739; GO:0005743; GO:0016021 0 0 0 PF04418; Q7TSW6 CHOYP_LOC100371786.1.1 m.60610 sp STIMA_RAT 46.748 246 124 3 29 274 26 264 2.44E-79 244 STIMA_RAT reviewed Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (STIMATE) (Transmembrane protein 110) Tmem110 Rattus norvegicus (Rat) 288 activation of store-operated calcium channel activity [GO:0032237]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; positive regulation of NFAT protein import into nucleus [GO:0051533] GO:0005246; GO:0005789; GO:0016021; GO:0032237; GO:0032541; GO:0035584; GO:0051533 0 0 0 PF12400; Q7Z408 CHOYP_SVEP1.1.8 m.21430 sp CSMD2_HUMAN 33.178 214 134 6 291 504 2737 2941 2.44E-23 108 CSMD2_HUMAN reviewed CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2) CSMD2 KIAA1884 Homo sapiens (Human) 3487 0 GO:0005886; GO:0016021 0 0 0 PF00431;PF00084; Q80U95 CHOYP_LOC577892.1.2 m.522 sp UBE3C_MOUSE 27.206 272 181 7 5 267 88 351 2.44E-21 96.7 UBE3C_MOUSE reviewed Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) Ube3c Kiaa0010 Kiaa10 Mus musculus (Mouse) 1083 protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0004842; GO:0005634; GO:0005737; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q86VX2 CHOYP_BRAFLDRAFT_108193.2.2 m.37878 sp COMD7_HUMAN 51.613 186 90 0 30 215 12 197 2.44E-64 201 COMD7_HUMAN reviewed COMM domain-containing protein 7 COMMD7 C20orf92 Homo sapiens (Human) 200 "negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" GO:0006351; GO:0016023; GO:0032088; GO:0033209; GO:0043231; GO:0045892; GO:0051059; GO:0070062 0 0 0 PF07258; Q8BG51 CHOYP_BRAFLDRAFT_93126.1.3 m.5722 sp MIRO1_MOUSE 50.725 345 137 4 1 341 310 625 2.44E-114 348 MIRO1_MOUSE reviewed Mitochondrial Rho GTPase 1 (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1) Rhot1 Arht1 Mus musculus (Mouse) 631 cellular homeostasis [GO:0019725]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrion transport along microtubule [GO:0047497]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005509; GO:0005525; GO:0005739; GO:0007264; GO:0016020; GO:0019725; GO:0031307; GO:0047497; GO:0097345 0 0 0 PF08355;PF08356;PF00071; Q8IWX5 CHOYP_SGPP2.1.1 m.8387 sp SGPP2_HUMAN 35.516 397 233 6 17 391 3 398 2.44E-75 242 SGPP2_HUMAN reviewed Sphingosine-1-phosphate phosphatase 2 (SPPase2) (Spp2) (hSPP2) (EC 3.1.3.-) (Sphingosine-1-phosphatase 2) SGPP2 Homo sapiens (Human) 399 sphingolipid biosynthetic process [GO:0030148]; sphingosine metabolic process [GO:0006670] GO:0005783; GO:0005789; GO:0006670; GO:0016021; GO:0030148; GO:0042392; GO:0070780 0 0 0 PF01569; Q8K0H5 CHOYP_BRAFLDRAFT_128646.1.1 m.11237 sp TAF10_MOUSE 71.901 121 28 3 44 161 100 217 2.44E-55 176 TAF10_MOUSE reviewed Transcription initiation factor TFIID subunit 10 (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30) (mTAFII30) Taf10 Taf2h Tafii30 Mus musculus (Mouse) 218 "apoptotic process [GO:0006915]; cellular protein complex assembly [GO:0043623]; DNA-templated transcription, initiation [GO:0006352]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte differentiation [GO:0070365]; histone deubiquitination [GO:0016578]; histone H3 acetylation [GO:0043966]; liver development [GO:0001889]; multicellular organism growth [GO:0035264]; protein homooligomerization [GO:0051260]; regulation of DNA binding [GO:0051101]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000082; GO:0000125; GO:0001889; GO:0003677; GO:0003713; GO:0005634; GO:0005669; GO:0005737; GO:0006352; GO:0006355; GO:0006367; GO:0006915; GO:0010468; GO:0016578; GO:0019899; GO:0030331; GO:0030914; GO:0033276; GO:0035264; GO:0043623; GO:0043966; GO:0048471; GO:0051101; GO:0051260; GO:0070063; GO:0070365 0 0 cd07982; PF03540; Q8K0U4 CHOYP_ISCW_ISCW012626.4.4 m.65568 sp HS12A_MOUSE 29.396 381 215 9 15 346 56 431 2.44E-45 167 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8ND71 CHOYP_GIMAP9.1.1 m.45953 sp GIMA8_HUMAN 26.923 182 125 5 19 197 250 426 2.44E-09 60.5 GIMA8_HUMAN reviewed GTPase IMAP family member 8 (Immune-associated nucleotide-binding protein 9) (IAN-9) (Protein IanT) GIMAP8 IAN9 IANT Homo sapiens (Human) 665 regulation of T cell apoptotic process [GO:0070232] GO:0005525; GO:0005654; GO:0005737; GO:0005739; GO:0005783; GO:0005794; GO:0005829; GO:0070232 0 0 0 PF04548; Q8NI08 CHOYP_LOC655529.3.3 m.65687 sp NCOA7_HUMAN 49.518 311 138 5 684 988 644 941 2.44E-89 309 NCOA7_HUMAN reviewed Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 Homo sapiens (Human) 942 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005622; GO:0005634; GO:0006351; GO:0030374; GO:0035257; GO:0045944 0 0 0 PF01476;PF07534; Q9BUJ2 CHOYP_LOC578672.1.2 m.29847 sp HNRL1_HUMAN 44.104 653 311 11 4 647 1 608 2.44E-159 491 HNRL1_HUMAN reviewed Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5) HNRNPUL1 E1BAP5 HNRPUL1 Homo sapiens (Human) 856 "mRNA splicing, via spliceosome [GO:0000398]; regulation of transcription, DNA-templated [GO:0006355]; response to virus [GO:0009615]; RNA processing [GO:0006396]; transcription, DNA-templated [GO:0006351]" GO:0000398; GO:0003723; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0006396; GO:0009615; GO:0019899; GO:0030529; GO:0044822 0 0 0 PF02037;PF00622; Q9CZJ0 CHOYP_MPPD2.1.3 m.25946 sp MPPD2_MOUSE 45.69 232 115 4 3 226 9 237 2.44E-61 196 MPPD2_MOUSE reviewed Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Metallophosphoesterase domain-containing protein 2) Mpped2 Mus musculus (Mouse) 294 0 GO:0016787; GO:0046872 0 0 0 PF00149; Q9HAR2 CHOYP_LPHN3.3.4 m.44721 sp AGRL3_HUMAN 35.441 680 386 22 265 906 453 1117 2.44E-122 408 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9HBI1 CHOYP_PARVB.1.2 m.43895 sp PARVB_HUMAN 68.768 349 107 1 13 361 16 362 2.44E-171 484 PARVB_HUMAN reviewed Beta-parvin (Affixin) PARVB CGI-56 Homo sapiens (Human) 364 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell projection assembly [GO:0030031]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; lamellipodium assembly [GO:0030032] GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0007155; GO:0030018; GO:0030027; GO:0030031; GO:0030032; GO:0031532; GO:0071963 0 0 0 PF00307; Q9MYN5 CHOYP_CDKN3.1.1 m.44295 sp CDKN3_PIG 50 188 94 0 19 206 10 197 2.44E-64 201 CDKN3_PIG reviewed Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Kinase-associated phosphatase) CDKN3 KAP Sus scrofa (Pig) 212 cell cycle arrest [GO:0007050]; G1/S transition of mitotic cell cycle [GO:0000082] GO:0000082; GO:0004722; GO:0004725; GO:0005634; GO:0005737; GO:0007050; GO:0008138; GO:0048471 0 0 0 PF05706; Q9ULJ7 CHOYP_TVAG_020440.18.21 m.54152 sp ANR50_HUMAN 34.739 403 258 1 1 398 676 1078 2.44E-63 223 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A0JM12 CHOYP_CELE_Y64G10A.7.3.4 m.53262 sp MEG10_XENTR 36.226 265 149 13 143 405 310 556 2.45E-28 120 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2TLM1 CHOYP_PHUM_PHUM353470.1.1 m.63458 sp RPIA_PIG 63.248 234 85 1 31 264 70 302 2.45E-103 306 RPIA_PIG reviewed Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase) RPIA Sus scrofa (Pig) 306 "pentose-phosphate shunt, non-oxidative branch [GO:0009052]" GO:0004751; GO:0009052 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. {ECO:0000250|UniProtKB:P49247}. 0 cd01398; PF06026; A3KNS9 CHOYP_MED7.1.1 m.48812 sp ARAID_DANRE 35.78 218 124 8 9 217 16 226 2.45E-27 107 ARAID_DANRE reviewed All-trans retinoic acid-induced differentiation factor (Apoptosis-related protein 3) (APR-3) atraid apr3 si:ch211-101l18.3 Danio rerio (Zebrafish) (Brachydanio rerio) 230 cell differentiation [GO:0030154]; negative regulation of cyclin catabolic process [GO:2000599]; negative regulation of osteoblast proliferation [GO:0033689]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of gene expression [GO:0010468] GO:0005635; GO:0005886; GO:0010468; GO:0016021; GO:0030154; GO:0030501; GO:0033689; GO:0045669; GO:0048471; GO:2000599 0 0 0 0 D2GXS7 CHOYP_contig_020829 m.23972 sp TRIM2_AILME 23.776 143 105 3 46 185 602 743 2.45E-07 53.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZQG6 CHOYP_TRIM2.28.59 m.34750 sp TRIM2_RAT 24.595 370 211 12 11 346 20 355 2.45E-13 74.7 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O46160 CHOYP_RL3.4.7 m.41935 sp RL14_LUMRU 66.667 132 44 0 4 135 5 136 2.45E-60 186 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O75496 CHOYP_LOC100313617.1.1 m.18024 sp GEMI_HUMAN 37.5 120 58 3 83 192 48 160 2.45E-15 75.5 GEMI_HUMAN reviewed Geminin GMNN Homo sapiens (Human) 209 "cell cycle [GO:0007049]; negative regulation of cell cycle [GO:0045786]; negative regulation of DNA replication [GO:0008156]; negative regulation of transcription, DNA-templated [GO:0045892]; organ morphogenesis [GO:0009887]; protein complex assembly [GO:0006461]" GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006461; GO:0007049; GO:0008156; GO:0009887; GO:0042826; GO:0045786; GO:0045892 0 0 0 PF07412; O88572 CHOYP_LRP6.6.6 m.62495 sp LRP6_MOUSE 32.075 265 170 4 26 288 327 583 2.45E-35 147 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; O95257 CHOYP_LOC101074436.1.1 m.59220 sp GA45G_HUMAN 37.168 113 68 2 12 122 14 125 2.45E-22 89.7 GA45G_HUMAN reviewed Growth arrest and DNA damage-inducible protein GADD45 gamma (Cytokine-responsive protein CR6) (DNA damage-inducible transcript 2 protein) (DDIT-2) GADD45G CR6 DDIT2 Homo sapiens (Human) 159 activation of MAPKKK activity [GO:0000185]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]; response to stress [GO:0006950] GO:0000185; GO:0005634; GO:0005737; GO:0006915; GO:0006950; GO:0007275; GO:0030154; GO:0043065; GO:0046330; GO:0051726; GO:1900745 0 0 0 PF01248; P02553 CHOYP_LOC584364.2.2 m.57790 sp TBA_LYTPI 98.667 150 2 0 1 150 12 161 2.45E-109 310 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P10079 CHOYP_NEMVEDRAFT_V1G100228.1.1 m.6071 sp FBP1_STRPU 50.292 171 85 0 1 171 343 513 2.45E-49 173 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10394 CHOYP_LOC100330808.2.2 m.52600 sp POL4_DROME 34.361 227 142 3 4 227 968 1190 2.45E-32 127 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P20241 CHOYP_DPSE_GA14061.1.1 m.18868 sp NRG_DROME 31.284 553 351 12 22 570 516 1043 2.45E-69 247 NRG_DROME reviewed Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) 1302 "axon ensheathment [GO:0008366]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell adhesion involved in heart morphogenesis [GO:0061343]; central complex development [GO:0048036]; dendrite morphogenesis [GO:0048813]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of glial blood-brain barrier [GO:0060857]; female courtship behavior [GO:0008050]; imaginal disc morphogenesis [GO:0007560]; male courtship behavior [GO:0008049]; melanotic encapsulation of foreign target [GO:0035011]; motor neuron axon guidance [GO:0008045]; mushroom body development [GO:0016319]; nerve maturation [GO:0021682]; neuron cell-cell adhesion [GO:0007158]; neuron projection morphogenesis [GO:0048812]; photoreceptor cell axon guidance [GO:0072499]; regulation of female receptivity [GO:0045924]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; synapse organization [GO:0050808]" GO:0005509; GO:0005886; GO:0005918; GO:0005919; GO:0005923; GO:0007158; GO:0007173; GO:0007409; GO:0007560; GO:0008045; GO:0008049; GO:0008050; GO:0008366; GO:0016021; GO:0016319; GO:0016328; GO:0019991; GO:0021682; GO:0030175; GO:0035011; GO:0035151; GO:0045924; GO:0048036; GO:0048675; GO:0048812; GO:0048813; GO:0050808; GO:0060857; GO:0061343; GO:0072499 0 0 0 PF13882;PF00041;PF07679;PF00047; P20695 CHOYP_BRAFLDRAFT_113696.1.1 m.54166 sp IFRD1_RAT 48.905 411 197 7 22 424 38 443 2.45E-117 353 IFRD1_RAT reviewed Interferon-related developmental regulator 1 (IRPR) (Nerve growth factor-inducible protein PC4) Ifrd1 Pc4 Rattus norvegicus (Rat) 449 glial cell proliferation [GO:0014009]; muscle cell differentiation [GO:0042692]; neuroblast proliferation [GO:0007405]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0005634; GO:0005737; GO:0005886; GO:0007405; GO:0014009; GO:0042692; GO:0045944; GO:0051091; GO:0061629 0 0 0 PF05004;PF04836; P24014 CHOYP_SLIT1.5.5 m.58713 sp SLIT_DROME 35.537 121 70 2 1 120 194 307 2.45E-15 77.8 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P25023 CHOYP_LOC101075438.1.1 m.25718 sp BKRB2_RAT 22.84 324 206 11 33 342 62 355 2.45E-07 55.5 BKRB2_RAT reviewed B2 bradykinin receptor (B2R) (BK-2 receptor) Bdkrb2 Rattus norvegicus (Rat) 396 acute inflammatory response to antigenic stimulus [GO:0002438]; cellular response to hypoxia [GO:0071456]; maintenance of blood-brain barrier [GO:0035633]; negative regulation of blood pressure [GO:0045776]; negative regulation of cell proliferation [GO:0008285]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to drug [GO:0042493]; sensory perception of pain [GO:0019233]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310] GO:0002438; GO:0004947; GO:0005886; GO:0006939; GO:0007204; GO:0008285; GO:0016021; GO:0019233; GO:0031698; GO:0035633; GO:0042310; GO:0042493; GO:0045776; GO:0071456 0 0 0 PF00001; P59889 CHOYP_F55F8.9.1.1 m.64216 sp S39A1_DANRE 35.811 148 92 2 241 387 156 301 2.45E-22 99.4 S39A1_DANRE reviewed Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1) slc39a1 zip1 sb:cb629 zgc:111852 Danio rerio (Zebrafish) (Brachydanio rerio) 302 zinc II ion transmembrane transport [GO:0071577]; zinc II ion transport [GO:0006829] GO:0005385; GO:0005886; GO:0006829; GO:0008270; GO:0016021; GO:0071577 0 0 0 PF02535; P62248 CHOYP_LOC101040300.2.2 m.16480 sp MYDGF_BOVIN 37.984 129 70 3 49 168 41 168 2.45E-23 94 MYDGF_BOVIN reviewed Myeloid-derived growth factor (MYDGF) MYDGF Bos taurus (Bovine) 174 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001525; GO:0001934; GO:0001938; GO:0005576; GO:0005615; GO:0005793; GO:0006915; GO:0014068; GO:0043066; GO:0043410; GO:0045766; GO:0045944; GO:0051897; GO:0070062 0 0 0 PF10572; P74897 CHOYP_NEMVEDRAFT_V1G241459.1.1 m.54504 sp YQA3_THEAQ 38.824 85 52 0 29 113 53 137 2.45E-11 59.7 YQA3_THEAQ reviewed Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) 0 Thermus aquaticus 137 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P82596 CHOYP_CLEC10A.1.3 m.5553 sp PLC_HALLA 33.645 107 63 3 14 119 29 128 2.45E-14 68.6 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; P82596 CHOYP_LOC100183059.4.4 m.49546 sp PLC_HALLA 33.071 127 75 3 254 380 12 128 2.45E-15 76.3 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q05974 CHOYP_RAB1A.2.3 m.25630 sp RAB1A_LYMST 68.5 200 59 2 1 197 4 202 2.45E-97 283 RAB1A_LYMST reviewed Ras-related protein Rab-1A RAB1A Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 205 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005783; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00071; Q0KIA2 CHOYP_ENPL.1.4 m.1126 sp Y9801_DROME 45.679 243 129 2 43 282 225 467 2.45E-63 223 Y9801_DROME reviewed PP2C-like domain-containing protein CG9801 CG9801 Drosophila melanogaster (Fruit fly) 709 0 GO:0003824 0 0 0 0 Q0V9R3 CHOYP_DI3L2.1.1 m.61980 sp DI3L2_XENTR 57.416 418 178 0 1 418 414 831 2.45E-175 514 DI3L2_XENTR reviewed DIS3-like exonuclease 2 (EC 3.1.13.-) dis3l2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 834 "cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic nuclear division [GO:0007067]; mRNA catabolic process [GO:0006402]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; stem cell population maintenance [GO:0019827]" GO:0000175; GO:0000176; GO:0000177; GO:0000291; GO:0000932; GO:0003723; GO:0005737; GO:0006364; GO:0006402; GO:0007067; GO:0010587; GO:0016075; GO:0019827; GO:0034427; GO:0046872; GO:0051301; GO:1990074 0 0 0 0 Q13439 CHOYP_GOLGA4.2.3 m.23648 sp GOGA4_HUMAN 36.607 112 57 5 1 103 2119 2225 2.45E-15 73.2 GOGA4_HUMAN reviewed Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) GOLGA4 Homo sapiens (Human) 2230 Golgi to plasma membrane protein transport [GO:0043001]; positive regulation of axon extension [GO:0045773]; protein targeting to Golgi [GO:0000042]; vesicle-mediated transport [GO:0016192] GO:0000042; GO:0000139; GO:0005654; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0016192; GO:0043001; GO:0043231; GO:0045773; GO:0051020; GO:0070062 0 0 0 PF01465; Q2KIJ2 CHOYP_LOC100549524.1.1 m.44193 sp MET18_BOVIN 38.819 237 114 3 80 290 126 357 2.45E-53 181 MET18_BOVIN reviewed Histidine protein methyltransferase 1 homolog (Methyltransferase-like protein 18) (EC 2.1.1.-) METTL18 Bos taurus (Bovine) 373 0 GO:0008168 0 0 0 PF10294; Q3ZBG9 CHOYP_LOC100377321.1.1 m.57245 sp PLS2_BOVIN 50 274 121 6 43 314 34 293 2.45E-85 261 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q5GLH2 CHOYP_TRIB2.1.1 m.227 sp TRIB2_BOVIN 55.172 348 142 8 1 340 1 342 2.45E-128 373 TRIB2_BOVIN reviewed Tribbles homolog 2 (TRB-2) TRIB2 Bos taurus (Bovine) 343 negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-10 biosynthetic process [GO:0045081]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405] GO:0004860; GO:0005634; GO:0005737; GO:0005856; GO:0031434; GO:0032436; GO:0043405; GO:0045081; GO:0045599; GO:0055106 0 0 0 PF00069; Q5ZLH0 CHOYP_AAEL_AAEL001706.1.1 m.43821 sp NXT2_CHICK 44.118 102 57 0 1 102 1 102 2.45E-31 110 NXT2_CHICK reviewed NTF2-related export protein 2 NXT2 RCJMB04_6d20 Gallus gallus (Chicken) 141 mRNA transport [GO:0051028]; protein transport [GO:0015031] GO:0005634; GO:0005737; GO:0015031; GO:0048471; GO:0051028 0 0 cd00780; PF02136; Q6GLQ4 CHOYP_PPP1R10.1.1 m.62373 sp PP1RA_XENLA 42.322 267 136 6 27 284 382 639 2.45E-44 167 PP1RA_XENLA reviewed Serine/threonine-protein phosphatase 1 regulatory subunit 10 ppp1r10 Xenopus laevis (African clawed frog) 819 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004864; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF08711; Q6R7F0 CHOYP_Y077.1.1 m.27641 sp Y079_OSHVF 100 146 0 0 1 146 1 146 2.45E-103 294 Y079_OSHVF reviewed Uncharacterized protein ORF79 ORF79 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 146 0 0 0 0 0 0 Q80U59 CHOYP_KIAA0232.1.1 m.50911 sp K0232_MOUSE 38.854 157 91 3 10 164 30 183 2.45E-16 89 K0232_MOUSE reviewed Uncharacterized protein KIAA0232 Kiaa0232 D5Ertd579e Mus musculus (Mouse) 1396 0 GO:0005524 0 0 0 PF15376; Q8N0N3 CHOYP_KMO.1.2 m.17497 sp BGBP_PENMO 50.568 352 157 9 43 390 24 362 2.45E-119 353 BGBP_PENMO reviewed "Beta-1,3-glucan-binding protein (GBP)" 0 Penaeus monodon (Giant tiger prawn) 366 carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087] GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087 0 0 0 PF00722; Q8N0N9 CHOYP_ODH.2.2 m.16624 sp ODH_HALDH 56.436 404 167 4 1 398 1 401 2.45E-163 467 ODH_HALDH reviewed Opine dehydrogenase (EC 1.5.1.-) tadh Haliotis discus hannai (Japanese abalone) 405 0 GO:0008677; GO:0050662 0 0 0 PF02558;PF02317; Q96M20 CHOYP_LOC100367077.1.1 m.62247 sp CNBD2_HUMAN 24.324 222 152 6 305 516 96 311 2.45E-08 61.2 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96MM6 CHOYP_LOC100699432.1.1 m.32144 sp HS12B_HUMAN 30.727 550 322 10 8 509 50 588 2.45E-82 275 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9CZJ2 CHOYP_HS12B.9.14 m.56389 sp HS12B_MOUSE 31.1 209 134 4 1 199 477 685 2.45E-28 114 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D844 CHOYP_DNAJC4.2.2 m.19500 sp DNJC4_MOUSE 52.083 48 20 1 35 79 39 86 2.45E-07 52.8 DNJC4_MOUSE reviewed DnaJ homolog subfamily C member 4 (Multiple endocrine neoplasia type 1 candidate protein number 18 homolog) Dnajc4 Mcg18 Mus musculus (Mouse) 244 0 GO:0005739; GO:0016021 0 0 cd06257; PF00226; Q9ESN6 CHOYP_BRAFLDRAFT_79377.21.30 m.53309 sp TRIM2_MOUSE 27.419 186 111 5 172 347 536 707 2.45E-10 65.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H939 CHOYP_BRAFLDRAFT_226416.1.1 m.56984 sp PPIP2_HUMAN 29.514 288 197 3 1 286 1 284 2.45E-34 130 PPIP2_HUMAN reviewed Proline-serine-threonine phosphatase-interacting protein 2 (PEST phosphatase-interacting protein 2) PSTPIP2 Homo sapiens (Human) 334 cell migration [GO:0016477]; cytoskeleton organization [GO:0007010] GO:0005829; GO:0005856; GO:0007010; GO:0016020; GO:0016477 0 0 0 PF00611; Q9NQP4 CHOYP_LOC100564354.1.1 m.46361 sp PFD4_HUMAN 57.851 121 50 1 11 130 12 132 2.45E-44 144 PFD4_HUMAN reviewed Prefoldin subunit 4 (Protein C-1) PFDN4 PFD4 Homo sapiens (Human) 134 protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006457; GO:0016272; GO:0051087 0 0 0 PF01920; Q9U221 CHOYP_BRAFLDRAFT_287444.2.5 m.7401 sp UNG_CAEEL 55.31 226 98 2 94 318 57 280 2.45E-87 266 UNG_CAEEL reviewed Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung-1 Y56A3A.29 Caenorhabditis elegans 282 base-excision repair [GO:0006284] GO:0004844; GO:0005634; GO:0005739; GO:0006284 0 0 cd10027; PF03167; Q9UKN7 CHOYP_LOC100901924.3.3 m.63996 sp MYO15_HUMAN 30.597 938 544 20 205 1098 2645 3519 2.45E-140 473 MYO15_HUMAN reviewed Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) 3530 inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0007626; GO:0016459; GO:0032420; GO:0042472; GO:0070062 0 0 0 PF00373;PF00612;PF00063;PF00784;PF07653; Q9XWD6 CHOYP_PEAR1.2.16 m.16010 sp CED1_CAEEL 37.021 235 129 11 184 416 591 808 2.45E-24 110 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; Q9Y5K3 CHOYP_ISCW_ISCW012957.1.2 m.51659 sp PCY1B_HUMAN 54.514 288 111 4 63 334 38 321 2.45E-114 340 PCY1B_HUMAN reviewed Choline-phosphate cytidylyltransferase B (EC 2.7.7.15) (CCT-beta) (CTP:phosphocholine cytidylyltransferase B) (CCT B) (CT B) (Phosphorylcholine transferase B) PCYT1B CCTB Homo sapiens (Human) 369 ovarian follicle development [GO:0001541]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid biosynthetic process [GO:0008654]; spermatogenesis [GO:0007283] GO:0001541; GO:0004105; GO:0005737; GO:0005789; GO:0006656; GO:0007283; GO:0008654 PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. {ECO:0000250|UniProtKB:P19836}. 0 0 PF01467; B2RU80 CHOYP_ALDH2.3.3 m.25045 sp PTPRB_MOUSE 43.836 292 145 8 2 288 1707 1984 2.46E-74 252 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; E1BD59 CHOYP_BRAFLDRAFT_82868.1.5 m.3498 sp TRI56_BOVIN 31.438 299 150 10 29 310 9 269 2.46E-31 133 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; G3X912 CHOYP_C14H1ORF124.1.1 m.18392 sp SPRTN_MOUSE 41.418 536 253 14 1 526 1 485 2.46E-125 379 SPRTN_MOUSE reviewed SprT-like domain-containing protein Spartan (Protein with SprT-like domain at the N terminus) (Spartan) Sprtn Gm505 Mus musculus (Mouse) 497 cellular response to DNA damage stimulus [GO:0006974]; positive regulation of protein ubiquitination [GO:0031398]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] GO:0003677; GO:0005634; GO:0005654; GO:0005694; GO:0006974; GO:0009411; GO:0016607; GO:0019985; GO:0031398; GO:0043130; GO:0046872; GO:0070530 0 0 0 PF10263; O00461 CHOYP_GOLI4.1.4 m.1816 sp GOLI4_HUMAN 26.289 194 117 2 3 170 4 197 2.46E-11 68.2 GOLI4_HUMAN reviewed "Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)" GOLIM4 GIMPC GOLPH4 GPP130 Homo sapiens (Human) 696 transport [GO:0006810] GO:0000139; GO:0005654; GO:0005794; GO:0005796; GO:0005801; GO:0006810; GO:0010008; GO:0016020; GO:0016021; GO:0030133; GO:0030139; GO:0032580 0 0 0 0 O16277 CHOYP_LOC100885792.3.3 m.55532 sp H16_CAEEL 47.917 96 48 2 26 119 15 110 2.46E-20 85.9 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O42384 CHOYP_AAEL_AAEL001606.1.1 m.40133 sp 5H1AB_TAKRU 23.045 243 148 9 4 218 10 241 2.46E-06 52.4 5H1AB_TAKRU reviewed 5-hydroxytryptamine receptor 1A-beta (5-HT-1A-beta) (5-HT1A-beta) (F1B) (Serotonin receptor 1A-beta) htr1a-B Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 416 adenylate cyclase-inhibiting serotonin receptor signaling pathway [GO:0007198]; behavior [GO:0007610]; cell proliferation [GO:0008283]; regulation of behavior [GO:0050795]; regulation of hormone secretion [GO:0046883]; serotonin receptor signaling pathway [GO:0007210]; vasoconstriction [GO:0042310] GO:0004993; GO:0005887; GO:0007198; GO:0007210; GO:0007610; GO:0008283; GO:0042310; GO:0046883; GO:0050795 0 0 0 PF00001; O70244 CHOYP_LOC101079407.1.1 m.28490 sp CUBN_RAT 29.057 265 151 10 27 283 1736 1971 2.46E-18 90.9 CUBN_RAT reviewed Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) 3623 cholesterol metabolic process [GO:0008203]; cobalamin transport [GO:0015889]; hemoglobin import [GO:0020028]; in utero embryonic development [GO:0001701]; protein homotrimerization [GO:0070207]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to nutrient [GO:0007584]; vitamin metabolic process [GO:0006766] GO:0001701; GO:0004872; GO:0005509; GO:0005765; GO:0005905; GO:0006766; GO:0006898; GO:0007584; GO:0008203; GO:0010008; GO:0015031; GO:0015235; GO:0015889; GO:0016020; GO:0020028; GO:0030135; GO:0030492; GO:0030666; GO:0031419; GO:0031526; GO:0042802; GO:0043202; GO:0043234; GO:0070207 0 0 0 PF00431;PF00008;PF12947;PF07645; O93603 CHOYP_TRHR.1.1 m.55917 sp TRFR_CHICK 29.878 164 112 2 8 168 18 181 2.46E-11 67.8 TRFR_CHICK reviewed Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Gallus gallus (Chicken) 395 0 GO:0004997; GO:0005886; GO:0016021 0 0 0 PF00001; P10394 CHOYP_LOC100708199.2.6 m.14407 sp POL4_DROME 27.98 990 599 20 296 1215 287 1232 2.46E-117 401 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P16924 CHOYP_LOC100369718.1.1 m.22116 sp P4HA1_CHICK 31.876 549 313 15 15 537 1 514 2.46E-68 232 P4HA1_CHICK reviewed "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 P4HA Gallus gallus (Chicken) 516 0 GO:0004656; GO:0005506; GO:0005788; GO:0016702; GO:0031418 0 0 0 PF13640;PF08336; P24733 CHOYP_ISCW_ISCW001340.1.1 m.1983 sp MYS_ARGIR 76.471 136 32 0 1 136 77 212 2.46E-67 226 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P41386 CHOYP_contig_015657 m.18313 sp TBB_HALDI 88.235 119 12 1 5 123 77 193 2.46E-69 214 TBB_HALDI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Haliotis discus (Abalone) (Nordotis discus) 341 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P45962 CHOYP_LOC585748.1.1 m.29341 sp KLP3_CAEEL 42.394 401 210 5 426 814 174 565 2.46E-91 302 KLP3_CAEEL reviewed Kinesin-like protein klp-3 klp-3 T09A5.2 Caenorhabditis elegans 598 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018]; neurogenesis [GO:0022008] GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0008574; GO:0022008; GO:0030030 0 0 0 PF00225; P48159 CHOYP_RL23.3.11 m.7669 sp RL23_DROME 90.714 140 13 0 21 160 1 140 2.46E-89 259 RL23_DROME reviewed 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) 140 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0006412; GO:0007052; GO:0017022; GO:0022008; GO:0022625; GO:0070180 0 0 0 PF00238; P82198 CHOYP_BRAFLDRAFT_127065.5.7 m.28848 sp BGH3_MOUSE 34.074 270 161 6 28 294 379 634 2.46E-31 126 BGH3_MOUSE reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) Tgfbi Mus musculus (Mouse) 683 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198] GO:0001525; GO:0002062; GO:0005518; GO:0005578; GO:0005604; GO:0005615; GO:0005802; GO:0007155; GO:0008283; GO:0030198; GO:0050839; GO:0050840; GO:0070062 0 0 0 PF02469; P98092 CHOYP_BRAFLDRAFT_118602.4.5 m.26803 sp HMCT_BOMMO 26.946 167 100 5 53 204 613 772 2.46E-08 58.2 HMCT_BOMMO reviewed Hemocytin (Humoral lectin) 0 Bombyx mori (Silk moth) 3133 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF08742;PF00754;PF01826;PF00094; Q13489 CHOYP_PIAP.3.3 m.66512 sp BIRC3_HUMAN 38.372 86 51 1 77 162 521 604 2.46E-13 69.7 BIRC3_HUMAN reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 MIHC RNF49 Homo sapiens (Human) 604 cell surface receptor signaling pathway [GO:0007166]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; protein heterooligomerization [GO:0051291]; regulation of apoptotic process [GO:0042981]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; spermatogenesis [GO:0007283]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007166; GO:0007249; GO:0007283; GO:0008270; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0031398; GO:0033209; GO:0034121; GO:0035666; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043234; GO:0045088; GO:0045121; GO:0050727; GO:0051291; GO:0060544; GO:0060546; GO:0070424; GO:1990001; GO:2000116 0 0 0 PF00653;PF00619; Q3TAS6 CHOYP_EMC10.1.1 m.11646 sp EMC10_MOUSE 36.765 204 117 6 42 237 45 244 2.46E-36 132 EMC10_MOUSE reviewed ER membrane protein complex subunit 10 (Hematopoietic signal peptide-containing membrane domain-containing protein 1) Emc10 Hsm1 Inm02 Mus musculus (Mouse) 258 0 GO:0005576; GO:0016021; GO:0072546 0 0 0 0 Q3U3W5 CHOYP_LOC101079919.1.1 m.35192 sp ANM9_MOUSE 32.057 836 472 19 10 768 28 844 2.46E-115 372 ANM9_MOUSE reviewed Putative protein arginine N-methyltransferase 9 (Putative protein arginine N-methyltransferase 10) (EC 2.1.1.-) Prmt9 Prmt10 Mus musculus (Mouse) 846 protein methylation [GO:0006479] GO:0006479; GO:0008168 0 0 0 0 Q4ZHG4 CHOYP_BRAFLDRAFT_87896.1.1 m.48667 sp FNDC1_HUMAN 39.516 124 70 3 222 344 1772 1891 2.46E-22 102 FNDC1_HUMAN reviewed Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) FNDC1 FNDC2 KIAA1866 MEL4B3 Homo sapiens (Human) 1894 0 GO:0005576; GO:0005654 0 0 0 PF00041; Q5ZLC6 CHOYP_ANR10.2.2 m.49232 sp ANR10_CHICK 36.426 291 152 5 8 288 7 274 2.46E-50 175 ANR10_CHICK reviewed Ankyrin repeat domain-containing protein 10 ANKRD10 RCJMB04_6l10 Gallus gallus (Chicken) 414 regulation of canonical Wnt signaling pathway [GO:0060828] GO:0060828 0 0 0 PF12796; Q66XS7 CHOYP_LOC100694882.1.2 m.10838 sp NDUS4_GEKJA 68.493 73 23 0 76 148 49 121 2.46E-32 115 NDUS4_GEKJA reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit)" NDUFS4 GekBS037P Gekko japonicus (Schlegel's Japanese gecko) 175 brain development [GO:0007420]; cAMP-mediated signaling [GO:0019933]; cellular respiration [GO:0045333]; electron transport chain [GO:0022900]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of fibroblast proliferation [GO:0048146]; reactive oxygen species metabolic process [GO:0072593]; response to cAMP [GO:0051591] GO:0005747; GO:0007420; GO:0016651; GO:0019933; GO:0022900; GO:0032981; GO:0045333; GO:0048146; GO:0051591; GO:0072593 0 0 0 PF04800; Q6PFY8 CHOYP_BRAFLDRAFT_86897.3.3 m.61656 sp TRI45_MOUSE 25.362 138 89 2 3 133 191 321 2.46E-07 54.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6V0K7 CHOYP_LOC794334.1.1 m.50146 sp OIT3_RAT 32.203 118 74 3 39 150 22 139 2.46E-11 67 OIT3_RAT reviewed Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) Oit3 Lzp Rattus norvegicus (Rat) 546 0 GO:0005509; GO:0005635 0 0 0 PF00100; Q8I7J4 CHOYP_CRE-COQ-2.1.1 m.5629 sp COQ2_CAEEL 50 64 23 2 109 172 37 91 2.46E-12 67 COQ2_CAEEL reviewed "4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)" coq-2 F57B9.4 Caenorhabditis elegans 356 isoprenoid biosynthetic process [GO:0008299]; ubiquinone biosynthetic process [GO:0006744] GO:0002083; GO:0006744; GO:0008299; GO:0031305; GO:0047293 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03189}. 0 0 PF01040; Q8I8V0 CHOYP_NEMVEDRAFT_V1G222546.1.1 m.45024 sp TAD2B_DROME 49.194 124 61 1 10 131 9 132 2.46E-38 140 TAD2B_DROME reviewed Transcriptional adapter 2B (dADA2b) Ada2b Ada2S CG9638 Drosophila melanogaster (Fruit fly) 555 "axon target recognition [GO:0007412]; chromatin remodeling [GO:0006338]; histone H3 acetylation [GO:0043966]; positive regulation of histone acetylation [GO:0035066]; regulation of terminal button organization [GO:2000331]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; wing disc pattern formation [GO:0035222]" GO:0000124; GO:0003677; GO:0003682; GO:0003700; GO:0003713; GO:0005634; GO:0005700; GO:0006338; GO:0006351; GO:0006355; GO:0006357; GO:0007412; GO:0008270; GO:0035066; GO:0035222; GO:0043966; GO:2000331 0 0 0 PF00249;PF00569; Q8NEU8 CHOYP_DP13A.1.3 m.905 sp DP13B_HUMAN 37.625 699 335 13 2 648 3 652 2.46E-146 444 DP13B_HUMAN reviewed "DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)" APPL2 DIP13B Homo sapiens (Human) 664 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; signal transduction [GO:0007165] GO:0005634; GO:0005737; GO:0007049; GO:0007165; GO:0008283; GO:0010008; GO:0031901; GO:0070062 0 0 0 PF00169;PF00640; Q8R143 CHOYP_LOC100375022.1.1 m.3034 sp PTTG_MOUSE 53.333 135 60 2 62 195 42 174 2.46E-32 117 PTTG_MOUSE reviewed Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor) Pttg1ip Mus musculus (Mouse) 174 "negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]" GO:0002039; GO:0005634; GO:0005737; GO:0005886; GO:0006606; GO:0016020; GO:0016021; GO:0031398; GO:0043518; GO:0070062; GO:1902254; GO:1903364 0 0 0 0 Q8TCT0 CHOYP_LCB4.1.1 m.56414 sp CERK1_HUMAN 34.632 231 147 3 54 280 81 311 2.46E-39 152 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q8TDM6 CHOYP_DLG5A.1.1 m.12202 sp DLG5_HUMAN 35.63 595 354 8 1401 1976 1334 1918 2.46E-106 382 DLG5_HUMAN reviewed Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) DLG5 KIAA0583 PDLG Homo sapiens (Human) 1919 apical protein localization [GO:0045176]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; intracellular signal transduction [GO:0035556]; metanephric collecting duct development [GO:0072205]; midbrain development [GO:0030901]; negative regulation of cell proliferation [GO:0008285]; polarized epithelial cell differentiation [GO:0030859]; protein complex assembly [GO:0006461]; protein localization to adherens junction [GO:0071896]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; single organismal cell-cell adhesion [GO:0016337]; zonula adherens assembly [GO:0045186] GO:0005737; GO:0005886; GO:0005913; GO:0006461; GO:0007165; GO:0008013; GO:0008092; GO:0008285; GO:0016337; GO:0030159; GO:0030859; GO:0030901; GO:0035556; GO:0042981; GO:0045176; GO:0045186; GO:0045197; GO:0060441; GO:0071896; GO:0072205 0 0 0 PF00625;PF00595;PF04822; Q90YR8 CHOYP_RS6.11.12 m.49599 sp RS6_ICTPU 87.654 81 10 0 1 81 1 81 2.46E-48 157 RS6_ICTPU reviewed 40S ribosomal protein S6 rps6 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 249 glucose homeostasis [GO:0042593]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0006412; GO:0022627; GO:0042593; GO:0048471 0 0 0 PF01092; Q9BE18 CHOYP_DICPUDRAFT_76009.1.1 m.13965 sp MAGE1_MACFA 26.829 328 210 5 1185 1500 58 367 2.46E-12 75.9 MAGE1_MACFA reviewed Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (MAGE-E1 antigen) MAGEE1 QflA-10248 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 957 0 GO:0005634; GO:0005886; GO:0030425; GO:0045211; GO:0048471 0 0 0 PF01454; Q9BU19 CHOYP_MC28_D181.1.1 m.45044 sp ZN692_HUMAN 46.939 49 26 0 102 150 13 61 2.46E-07 56.2 ZN692_HUMAN reviewed Zinc finger protein 692 ZNF692 Homo sapiens (Human) 519 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q9BZA8 CHOYP_PCDH7.3.3 m.56226 sp PC11Y_HUMAN 34.363 777 485 12 3 767 41 804 2.46E-119 401 PC11Y_HUMAN reviewed Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22) PCDH11Y PCDH11 PCDH22 PCDHY Homo sapiens (Human) 1340 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q9CZJ2 CHOYP_HS12A.13.33 m.40649 sp HS12B_MOUSE 28.019 621 363 22 237 782 61 672 2.46E-61 223 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9ESN3 CHOYP_LOC101078808.1.1 m.49520 sp TMM8A_MOUSE 29.076 736 450 24 54 766 54 740 2.46E-76 266 TMM8A_MOUSE reviewed Transmembrane protein 8A (M83 protein) (Transmembrane protein 8) Tmem8a Tmem8 Mus musculus (Mouse) 769 cell adhesion [GO:0007155] GO:0005765; GO:0005886; GO:0005887; GO:0007155; GO:0070062 0 0 0 PF12036; Q9H251 CHOYP_LOC100372197.2.3 m.41730 sp CAD23_HUMAN 26.937 271 179 7 39 302 899 1157 2.46E-14 77.8 CAD23_HUMAN reviewed Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) 3354 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0005509; GO:0005886; GO:0006816; GO:0007156; GO:0007601; GO:0007605; GO:0007626; GO:0016020; GO:0016021; GO:0016339; GO:0032420; GO:0045494; GO:0050896; GO:0050953; GO:0050957; GO:0051480; GO:0060122 0 0 0 PF00028; Q9JK66 CHOYP_PRKN2.1.1 m.54903 sp PRKN2_RAT 41.578 469 209 10 6 417 3 463 2.46E-113 343 PRKN2_RAT reviewed E3 ubiquitin-protein ligase parkin (EC 6.3.2.-) Park2 Prkn Rattus norvegicus (Rat) 465 "adult locomotory behavior [GO:0008344]; aggresome assembly [GO:0070842]; cellular protein modification process [GO:0006464]; cellular response to manganese ion [GO:0071287]; cellular response to toxic substance [GO:0097237]; mitochondrial fission [GO:0000266]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000422]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of glucokinase activity [GO:0033132]; negative regulation of insulin secretion [GO:0046676]; negative regulation of JNK cascade [GO:0046329]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron death [GO:1901215]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; neuron cellular homeostasis [GO:0070050]; neuron maturation [GO:0042551]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of DNA binding [GO:0043388]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein K6-linked ubiquitination [GO:0085020]; protein localization to mitochondrion [GO:0070585]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of mitochondrion organization [GO:0010821]; response to corticosterone [GO:0051412]; response to drug [GO:0042493]; response to endoplasmic reticulum stress [GO:0034976]; response to oxidative stress [GO:0006979]; response to unfolded protein [GO:0006986]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]; zinc ion homeostasis [GO:0055069]" GO:0000139; GO:0000151; GO:0000209; GO:0000266; GO:0000422; GO:0000976; GO:0001664; GO:0001933; GO:0004842; GO:0005622; GO:0005634; GO:0005737; GO:0005739; GO:0005783; GO:0005789; GO:0005829; GO:0006351; GO:0006464; GO:0006511; GO:0006513; GO:0006979; GO:0006986; GO:0007005; GO:0008021; GO:0008344; GO:0010506; GO:0010636; GO:0010637; GO:0010821; GO:0010918; GO:0014069; GO:0016235; GO:0016567; GO:0016874; GO:0019901; GO:0030054; GO:0030165; GO:0030425; GO:0030672; GO:0031410; GO:0031624; GO:0032403; GO:0032436; GO:0033132; GO:0034976; GO:0035774; GO:0042493; GO:0042551; GO:0042787; GO:0042802; GO:0042981; GO:0043005; GO:0043123; GO:0043130; GO:0043161; GO:0043388; GO:0043524; GO:0045121; GO:0045202; GO:0045211; GO:0045944; GO:0046329; GO:0046676; GO:0046872; GO:0051412; GO:0051646; GO:0051865; GO:0051967; GO:0055069; GO:0061630; GO:0070050; GO:0070534; GO:0070585; GO:0070842; GO:0070936; GO:0070979; GO:0071287; GO:0085020; GO:0090141; GO:0090201; GO:0090258; GO:0090394; GO:0097237; GO:0097602; GO:1900407; GO:1901215; GO:1902236; GO:1903204; GO:1903265; GO:1903377; GO:1903427; GO:1990444; GO:1990452; GO:2000378; GO:2001171 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485;PF00240; Q9UGM3 CHOYP_DMBT1.22.34 m.45432 sp DMBT1_HUMAN 40.841 666 311 16 19 608 484 1142 2.46E-131 451 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9VCA8 CHOYP_LOC100637968.8.12 m.46383 sp ANKHM_DROME 33.14 344 208 13 16 343 619 956 2.46E-39 152 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VGZ0 CHOYP_BRAFLDRAFT_91869.1.1 m.2161 sp C12E1_DROME 34.737 95 51 3 31 121 27 114 2.46E-11 63.2 C12E1_DROME reviewed "Probable cytochrome P450 12e1, mitochondrial (EC 1.14.-.-) (CYPXIIE1)" Cyp12e1 CG14680 Drosophila melanogaster (Fruit fly) 522 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037; GO:0031966 0 0 0 PF00067; Q9Y5A7 CHOYP_LOC583762.1.1 m.60728 sp NUB1_HUMAN 35.42 607 345 10 45 627 10 593 2.46E-106 337 NUB1_HUMAN reviewed NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) NUB1 NYREN18 Homo sapiens (Human) 615 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; response to interferon-gamma [GO:0034341]; response to tumor necrosis factor [GO:0034612]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005634; GO:0006511; GO:0016567; GO:0032436; GO:0034341; GO:0034612 0 0 0 PF00627; Q9Y6R7 CHOYP_STAUR_2903.1.1 m.49332 sp FCGBP_HUMAN 21.93 342 239 9 83 409 20 348 2.46E-13 76.6 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; Q9YIC0 CHOYP_EF1A1.1.1 m.50593 sp EF1A_ORYLA 82.609 299 39 1 1 299 102 387 2.46E-180 509 EF1A_ORYLA reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; D2GXS7 CHOYP_BRAFLDRAFT_67264.4.6 m.42082 sp TRIM2_AILME 23.973 146 105 3 412 555 602 743 2.47E-08 60.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_84664.1.7 m.3969 sp TRIM2_AILME 26.036 169 113 4 249 407 578 744 2.47E-07 56.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O01369 CHOYP_RPS27L.1.1 m.21536 sp QCR7_FASHE 39.175 97 59 0 15 111 25 121 2.47E-19 80.1 QCR7_FASHE reviewed Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) UBCRBP Fasciola hepatica (Liver fluke) 130 "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" GO:0005750; GO:0006122 0 0 0 PF02271; O02350 CHOYP_LOC590567.1.1 m.29483 sp CBPA1_ANOGA 39.173 411 234 7 8 412 19 419 2.47E-106 323 CBPA1_ANOGA reviewed Zinc carboxypeptidase A 1 (EC 3.4.17.-) (AgCP) AGAP009593 Anopheles gambiae (African malaria mosquito) 433 digestion [GO:0007586] GO:0004181; GO:0005615; GO:0007586; GO:0008270 0 0 0 PF00246;PF02244; O14511 CHOYP_LOC101164582.2.2 m.64299 sp NRG2_HUMAN 30.357 280 158 11 36 300 124 381 2.47E-25 109 NRG2_HUMAN reviewed "Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]" NRG2 NTAK Homo sapiens (Human) 850 animal organ development [GO:0048513]; ERBB2 signaling pathway [GO:0038128]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; phosphatidylinositol-mediated signaling [GO:0048015]; regulation of cell motility [GO:2000145]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; signal transduction [GO:0007165] GO:0000165; GO:0004713; GO:0005088; GO:0005102; GO:0005576; GO:0005615; GO:0005622; GO:0005886; GO:0007165; GO:0014066; GO:0016021; GO:0035556; GO:0038128; GO:0046934; GO:0048015; GO:0048513; GO:2000145 0 0 0 PF07679;PF02158; O17320 CHOYP_ACT3.3.3 m.66910 sp ACT_CRAGI 100 91 0 0 1 91 1 91 2.47E-61 194 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O73689 CHOYP_ZIC1.2.2 m.10870 sp ZIC1_XENLA 50.63 397 152 12 2 377 37 410 2.47E-120 362 ZIC1_XENLA reviewed Zinc finger protein ZIC 1 (XZic1) (XlZic1) (ODD-paired-like) (Xopl) (ZIC-related protein 1) (ZIC-r1) (Zinc finger protein of the cerebellum 1) zic1 opl Xenopus laevis (African clawed frog) 443 "dorsal/ventral neural tube patterning [GO:0021904]; neural crest cell differentiation [GO:0014033]; neural crest cell fate commitment [GO:0014034]; neural crest formation [GO:0014029]; neural plate development [GO:0001840]; neurogenesis [GO:0022008]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0001840; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0014029; GO:0014033; GO:0014034; GO:0016055; GO:0021904; GO:0022008; GO:0030177; GO:0042307; GO:0045893; GO:0045944; GO:0046872 0 0 0 PF00096; P02552 CHOYP_LOC585338.1.2 m.19090 sp TBA1_CHICK 98.387 62 1 0 1 62 164 225 2.47E-36 130 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P16157 CHOYP_TVAG_020440.9.21 m.21067 sp ANK1_HUMAN 39.067 343 209 0 4 346 255 597 2.47E-61 215 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20693 CHOYP_FCER2.2.9 m.2815 sp FCER2_MOUSE 40.69 145 77 5 38 180 189 326 2.47E-23 100 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P28827 CHOYP_PTPRM.7.15 m.45491 sp PTPRM_HUMAN 35.097 718 412 17 644 1323 731 1432 2.47E-115 398 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P34371 CHOYP_NEMVEDRAFT_V1G198958.2.6 m.26851 sp BAT42_CAEEL 24.409 127 87 3 3 126 214 334 2.47E-07 53.9 BAT42_CAEEL reviewed BTB and MATH domain-containing protein 42 bath-42 C50C3.8 Caenorhabditis elegans 410 protein ubiquitination [GO:0016567] GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00651; P58283 CHOYP_LOC100142249.1.1 m.55762 sp RN216_MOUSE 39.056 233 135 5 558 785 471 701 2.47E-42 170 RN216_MOUSE reviewed E3 ubiquitin-protein ligase RNF216 (EC 6.3.2.-) (RING finger protein 216) (Triad domain-containing protein 3) (UbcM4-interacting protein 83) (Ubiquitin-conjugating enzyme 7-interacting protein 1) Rnf216 Triad3 Ubce7ip1 Uip83 Zin Mus musculus (Mouse) 853 apoptotic process [GO:0006915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein linear polyubiquitination [GO:0097039]; regulation of defense response to virus by host [GO:0050691]; regulation of interferon-beta production [GO:0032648] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0006915; GO:0016874; GO:0032648; GO:0043130; GO:0043161; GO:0046872; GO:0050691; GO:0061630; GO:0070936; GO:0097039 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 P82596 CHOYP_LEC3.1.1 m.31054 sp PLC_HALLA 33.577 137 86 4 28 164 1 132 2.47E-22 90.5 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; P84336 CHOYP_ACTB.2.3 m.24136 sp ACTB_CAMDR 49.049 263 115 1 22 265 2 264 2.47E-88 270 ACTB_CAMDR reviewed "Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]" ACTB Camelus dromedarius (Dromedary) (Arabian camel) 375 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; P86854 CHOYP_CLC10.5.5 m.18472 sp PLCL_MYTGA 32.215 149 95 5 5 149 10 156 2.47E-21 87.8 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P91850 CHOYP_DANA_GF24843.1.2 m.17022 sp MIFH_BRUMA 42.982 114 63 2 94 205 2 115 2.47E-24 95.5 MIFH_BRUMA reviewed Macrophage migration inhibitory factor homolog (Bm-MIF-1) (BmMIF) (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) Bm1_28435 BMBAC01P19.1 Brugia malayi (Filarial nematode worm) 115 0 GO:0004167; GO:0005615; GO:0050178 0 0 0 PF01187; Q3KP44 CHOYP_ANKRD55.1.1 m.6587 sp ANR55_HUMAN 47.077 325 164 2 67 388 31 350 2.47E-90 298 ANR55_HUMAN reviewed Ankyrin repeat domain-containing protein 55 ANKRD55 Homo sapiens (Human) 614 0 0 0 0 0 PF12796; Q3SZ90 CHOYP_CHAT.1.1 m.36653 sp RL13A_BOVIN 58.537 123 51 0 1 123 79 201 2.47E-48 156 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q3SZ90 CHOYP_EPN4.2.3 m.66031 sp RL13A_BOVIN 58.537 123 51 0 1 123 79 201 2.47E-48 156 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q3SZ90 CHOYP_RL13A.1.3 m.25931 sp RL13A_BOVIN 58.537 123 51 0 1 123 79 201 2.47E-48 156 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q460N5 CHOYP_BRAFLDRAFT_74874.6.9 m.53650 sp PAR14_HUMAN 28.84 586 378 12 9 581 715 1274 2.47E-61 224 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5I2E5 CHOYP_FCN2.1.2 m.4038 sp FCN2_BOVIN 49.73 185 82 5 156 339 121 295 2.47E-49 171 FCN2_BOVIN reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) 329 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0046872 0 0 0 PF01391;PF00147; Q5ZJB4 CHOYP_IKKA.2.6 m.21762 sp IKKA_CHICK 33.651 315 174 8 2 291 454 758 2.47E-42 158 IKKA_CHICK reviewed Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) CHUK IKKA RCJMB04_19h23 Gallus gallus (Chicken) 759 cellular response to tumor necrosis factor [GO:0071356]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0008384; GO:0042803; GO:0045944; GO:0046982; GO:0071356 0 0 0 PF12179;PF00069; Q60953 CHOYP_LOC100369333.29.32 m.54497 sp PML_MOUSE 22.597 385 242 12 5 377 51 391 2.47E-19 97.4 PML_MOUSE reviewed Protein PML Pml Mus musculus (Mouse) 885 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell aging [GO:0007569]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of interleukin-1 secretion [GO:0050711]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0007569; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045345; GO:0045892; GO:0045944; GO:0046332; GO:0048146; GO:0048384; GO:0050711; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060444; GO:0070059; GO:0071353; GO:0072332; GO:0090398; GO:0097191; GO:1902187; GO:2000059; GO:2000779; GO:2001235; GO:2001238 0 0 0 PF12126;PF00643; Q86TC9 CHOYP_TITIN.3.19 m.12102 sp MYPN_HUMAN 25.828 302 183 6 134 427 267 535 2.47E-19 94.4 MYPN_HUMAN reviewed Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) 1320 sarcomere organization [GO:0045214] GO:0005634; GO:0008092; GO:0017124; GO:0030018; GO:0031674; GO:0045214; GO:0051371 0 0 0 PF07679; Q8K0U4 CHOYP_BRAFLDRAFT_208293.16.20 m.61632 sp HS12A_MOUSE 32.263 654 358 16 20 617 50 674 2.47E-97 315 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N0Z6 CHOYP_LOC100370957.1.1 m.22435 sp TTC5_HUMAN 52.57 428 201 2 4 429 13 440 2.47E-155 449 TTC5_HUMAN reviewed Tetratricopeptide repeat protein 5 (TPR repeat protein 5) (Stress-responsive activator of p300) (Strap) TTC5 Homo sapiens (Human) 440 DNA repair [GO:0006281]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of signal transduction by p53 class mediator [GO:1901796] GO:0003677; GO:0003682; GO:0005654; GO:0005737; GO:0006281; GO:0045944; GO:1901796 0 0 0 PF16669; Q8N2E2 CHOYP_BRAFLDRAFT_99629.4.4 m.54844 sp VWDE_HUMAN 44.737 76 35 4 1 73 1321 1392 2.47E-06 54.7 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NFG4 CHOYP_FLCN.1.1 m.65771 sp FLCN_HUMAN 41.522 578 284 12 1 531 1 571 2.47E-148 441 FLCN_HUMAN reviewed Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein) FLCN BHD Homo sapiens (Human) 579 cell-cell junction assembly [GO:0007043]; hemopoiesis [GO:0030097]; in utero embryonic development [GO:0001701]; negative regulation of ATP biosynthetic process [GO:2001170]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation involved in kidney development [GO:1901723]; negative regulation of energy homeostasis [GO:2000506]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of mitochondrion organization [GO:0010823]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of cell adhesion [GO:0045785]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of cytokinesis [GO:0032465]; regulation of histone acetylation [GO:0035065]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; regulation of TOR signaling [GO:0032006]; TOR signaling [GO:0031929] GO:0000122; GO:0001701; GO:0001932; GO:0001934; GO:0005085; GO:0005634; GO:0005737; GO:0005764; GO:0005886; GO:0007043; GO:0010508; GO:0010629; GO:0010823; GO:0030097; GO:0030308; GO:0030336; GO:0030511; GO:0031929; GO:0032006; GO:0032007; GO:0032008; GO:0032403; GO:0032465; GO:0035024; GO:0035065; GO:0043065; GO:0045785; GO:0045944; GO:0051898; GO:0070373; GO:0072372; GO:1900181; GO:1901723; GO:2000506; GO:2000973; GO:2001170 0 0 0 PF16692; Q8R2K1 CHOYP_LOC100377200.2.2 m.33666 sp FUCM_MOUSE 61.111 144 55 1 20 163 4 146 2.47E-60 187 FUCM_MOUSE reviewed Fucose mutarotase (EC 5.1.3.29) Fuom Le51 Mus musculus (Mouse) 153 female mating behavior [GO:0060180]; fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]; negative regulation of neuron differentiation [GO:0045665] GO:0006004; GO:0016857; GO:0036065; GO:0042806; GO:0045665; GO:0060180 0 0 0 PF05025; Q8VIK5 CHOYP_CED1.28.29 m.65646 sp PEAR1_MOUSE 31.674 221 114 13 159 351 94 305 2.47E-11 69.7 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q92197 CHOYP_LOC100647512.1.3 m.5829 sp CHSC_ASPFU 26.014 419 235 16 835 1179 355 772 2.47E-21 104 CHSC_ASPFU reviewed Chitin synthase C (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase C) (Class-III chitin synthase C) chsC AFUA_5G00760 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) 893 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0071555 0 0 0 PF01644;PF08407; Q92804 CHOYP_LOC100879389.2.2 m.63959 sp RBP56_HUMAN 38.462 377 162 12 12 338 28 384 2.47E-49 179 RBP56_HUMAN reviewed TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) TAF15 RBP56 TAF2N Homo sapiens (Human) 592 "positive regulation of transcription, DNA-templated [GO:0045893]" GO:0000166; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0044822; GO:0045893 0 0 0 PF00076;PF00641; Q96ER3 CHOYP_LOC100718468.1.1 m.11334 sp SAAL1_HUMAN 32.515 489 253 12 38 494 2 445 2.47E-71 239 SAAL1_HUMAN reviewed Protein SAAL1 SAAL1 Homo sapiens (Human) 474 0 GO:0005615 0 0 0 0 Q96LU5 CHOYP_IMP2L.1.1 m.56822 sp IMP1L_HUMAN 43.651 126 66 2 29 149 30 155 2.47E-29 108 IMP1L_HUMAN reviewed Mitochondrial inner membrane protease subunit 1 (EC 3.4.21.-) (IMP1-like protein) IMMP1L Homo sapiens (Human) 166 mitochondrial respiratory chain complex assembly [GO:0033108]; protein processing involved in protein targeting to mitochondrion [GO:0006627]; signal peptide processing [GO:0006465] GO:0004252; GO:0005739; GO:0006465; GO:0006627; GO:0033108; GO:0042720 0 0 0 PF00717; Q96XY5 CHOYP_PAR14.11.17 m.52138 sp Y2383_SULTO 43.243 148 79 1 701 848 1 143 2.47E-34 132 Y2383_SULTO reviewed Uncharacterized protein STK_23830 STK_23830 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 182 0 0 0 0 0 PF01661; Q9BRJ6 CHOYP_NEMVEDRAFT_V1G238825.1.1 m.4702 sp CG050_HUMAN 40 125 62 2 119 230 50 174 2.47E-25 101 CG050_HUMAN reviewed Uncharacterized protein C7orf50 C7orf50 FP15621 Homo sapiens (Human) 194 0 GO:0044822 0 0 0 PF10180; Q9CR48 CHOYP_LOC100576447.1.2 m.3657 sp DRAM2_MOUSE 36.842 228 135 5 6 228 8 231 2.47E-41 146 DRAM2_MOUSE reviewed DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) Dram2 Tmem77 Mus musculus (Mouse) 267 apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601] GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006914; GO:0006915; GO:0007601; GO:0010506; GO:0016021; GO:0016324; GO:0043231; GO:0045494 0 0 0 PF10277; Q9CYB0 CHOYP_LOC101072704.1.1 m.6613 sp TRI13_MOUSE 22.491 289 184 8 6 278 1 265 2.47E-15 82 TRI13_MOUSE reviewed E3 ubiquitin-protein ligase TRIM13 (EC 6.3.2.-) (Putative tumor suppressor RFP2) (Ret finger protein 2) (Tripartite motif-containing protein 13) Trim13 Rfp2 Mus musculus (Mouse) 407 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; innate immune response [GO:0045087]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell death [GO:0010942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; response to gamma radiation [GO:0010332] GO:0004842; GO:0004871; GO:0005737; GO:0005789; GO:0008270; GO:0010332; GO:0010942; GO:0016021; GO:0016239; GO:0016874; GO:0030433; GO:0032897; GO:0043123; GO:0043161; GO:0045087; GO:0051092; GO:0051865; GO:0097038; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q9IBD8 CHOYP_PTPRT.29.45 m.52800 sp PTPRC_CYPCA 37.402 254 145 6 342 589 581 826 2.47E-43 170 PTPRC_CYPCA reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45) ptprc Cyprinus carpio (Common carp) 1216 T cell receptor signaling pathway [GO:0050852] GO:0004725; GO:0016021; GO:0050852 0 0 0 PF00102; Q9P802 CHOYP_CAOG_01448.1.1 m.48639 sp MIS18_SCHPO 37.383 107 63 2 38 143 14 117 2.47E-14 74.3 MIS18_SCHPO reviewed Kinetochore protein mis18 mis18 SPCC970.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 194 cell division [GO:0051301]; CENP-A containing chromatin organization [GO:0061641]; kinetochore assembly [GO:0051382]; mitotic sister chromatid segregation [GO:0000070] GO:0000070; GO:0000778; GO:0005737; GO:0046872; GO:0051301; GO:0051382; GO:0061641; GO:0098654 0 0 0 PF03226; Q9U489 CHOYP_BRAFLDRAFT_69798.19.22 m.59758 sp LIN41_CAEEL 31.068 103 59 4 251 345 859 957 2.47E-06 53.1 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9UHJ6 CHOYP_SHPK.1.1 m.18243 sp SHPK_HUMAN 43.925 321 168 3 1 315 152 466 2.47E-93 288 SHPK_HUMAN reviewed Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase-like protein) SHPK CARKL Homo sapiens (Human) 478 "carbohydrate metabolic process [GO:0005975]; cellular response to interleukin-13 [GO:0035963]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; phosphorylation [GO:0016310]; regulation of inflammatory response [GO:0050727]; regulation of macrophage activation [GO:0043030]" GO:0005524; GO:0005737; GO:0005975; GO:0009052; GO:0016310; GO:0035963; GO:0043030; GO:0050277; GO:0050727; GO:0071222; GO:0071353 0 0 0 PF00370; Q9VZW5 CHOYP_LOC100902568.1.1 m.31344 sp FMAR_DROME 28.011 357 212 11 2 332 118 455 2.47E-30 124 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; A4IGL7 CHOYP_BRAFLDRAFT_125550.4.5 m.38690 sp PXDN_XENTR 34.286 595 339 16 127 686 726 1303 2.48E-98 334 PXDN_XENTR reviewed Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1457 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF03098;PF07679;PF13855;PF00093; B1AR13 CHOYP_AGAP_AGAP004885.1.1 m.29831 sp CISD3_MOUSE 33.813 139 82 3 8 146 1 129 2.48E-21 86.7 CISD3_MOUSE reviewed "CDGSH iron-sulfur domain-containing protein 3, mitochondrial (Melanoma nuclear protein 13)" Cisd3 Mel-13 Mel13 Mus musculus (Mouse) 137 0 GO:0005739; GO:0046872; GO:0051537 0 0 0 PF09360; B6VQA1 CHOYP_LOC100877118.1.1 m.39719 sp DIMM_DROME 72.368 76 20 1 82 156 143 218 2.48E-29 115 DIMM_DROME reviewed Protein dimmed dimm CG8667 Drosophila melanogaster (Fruit fly) 390 "neuroendocrine cell differentiation [GO:0061101]; positive regulation of hormone secretion [GO:0046887]; positive regulation of peptide secretion [GO:0002793]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]" GO:0002793; GO:0003677; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007419; GO:0045944; GO:0046887; GO:0061101 0 0 0 PF00010; D2GXS7 CHOYP_LOC100369014.3.9 m.32782 sp TRIM2_AILME 23.361 244 171 7 37 269 492 730 2.48E-06 52 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P09478 CHOYP_LOC100533250.1.2 m.31963 sp ACH1_DROME 48.052 539 206 7 21 497 20 546 2.48E-173 503 ACH1_DROME reviewed Acetylcholine receptor subunit alpha-like 1 (Nicotinic acetylcholine receptor alpha 1) nAChRalpha1 Acr96Aa AcrB als nAcRalpha-96Aa CG5610 Drosophila melanogaster (Fruit fly) 567 "cation transport [GO:0006812]; neuromuscular synaptic transmission [GO:0007274]; response to insecticide [GO:0017085]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0006812; GO:0007165; GO:0007271; GO:0007274; GO:0017085; GO:0030054; GO:0035094; GO:0045211 0 0 0 PF02931;PF02932; P61258 CHOYP_ISCW_ISCW022029.1.1 m.9014 sp PCNA_MACFA 72.201 259 72 0 1 259 1 259 2.48E-144 407 PCNA_MACFA reviewed Proliferating cell nuclear antigen (PCNA) PCNA Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 261 DNA replication [GO:0006260]; positive regulation of deoxyribonuclease activity [GO:0032077]; regulation of DNA replication [GO:0006275]; translesion synthesis [GO:0019985] GO:0003677; GO:0006260; GO:0006275; GO:0019985; GO:0030337; GO:0032077; GO:0070557 0 0 0 PF02747;PF00705; P78417 CHOYP_GSTO1.1.2 m.14745 sp GSTO1_HUMAN 43.568 241 126 5 3 237 5 241 2.48E-62 198 GSTO1_HUMAN reviewed Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) GSTO1 GSTTLP28 Homo sapiens (Human) 241 cellular response to arsenic-containing substance [GO:0071243]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; L-ascorbic acid biosynthetic process [GO:0019853]; L-ascorbic acid metabolic process [GO:0019852]; methylation [GO:0032259]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014810]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; xenobiotic catabolic process [GO:0042178] GO:0004364; GO:0005604; GO:0005737; GO:0005829; GO:0006749; GO:0010880; GO:0010881; GO:0014810; GO:0016491; GO:0019852; GO:0019853; GO:0030424; GO:0031965; GO:0032259; GO:0042178; GO:0043209; GO:0044297; GO:0045174; GO:0050610; GO:0060315; GO:0060316; GO:0070062; GO:0071243; GO:1901687 0 0 0 PF14497;PF13417; Q05722 CHOYP_CLJU_C04260.1.1 m.57979 sp CO9A1_MOUSE 37.132 272 99 11 114 369 428 643 2.48E-17 87.4 CO9A1_MOUSE reviewed Collagen alpha-1(IX) chain Col9a1 Mus musculus (Mouse) 921 cartilage development [GO:0051216]; growth plate cartilage development [GO:0003417]; tissue homeostasis [GO:0001894] GO:0001894; GO:0003417; GO:0005578; GO:0005594; GO:0046872; GO:0051216 0 0 0 PF01391; Q09128 CHOYP_LOC101175691.1.1 m.55537 sp CP24A_RAT 34.829 468 295 5 63 526 53 514 2.48E-101 317 CP24A_RAT reviewed "1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)" Cyp24a1 Cyp24 Rattus norvegicus (Rat) 514 osteoblast differentiation [GO:0001649]; response to vitamin D [GO:0033280]; vitamin D catabolic process [GO:0042369]; vitamin D metabolic process [GO:0042359] GO:0001649; GO:0005506; GO:0005654; GO:0005739; GO:0005886; GO:0008403; GO:0020037; GO:0030342; GO:0033280; GO:0042359; GO:0042369 0 0 0 PF00067; Q12542 CHOYP_LOC100206475.4.16 m.23178 sp LAC2_AGABI 31.122 588 263 20 102 668 22 488 2.48E-57 207 LAC2_AGABI reviewed Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Laccase II) (Urishiol oxidase 2) lcc2 Agaricus bisporus (White button mushroom) 520 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q13163 CHOYP_MP2K5.1.1 m.45311 sp MP2K5_HUMAN 48.472 458 199 6 1 450 12 440 2.48E-144 422 MP2K5_HUMAN reviewed Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) MAP2K5 MEK5 MKK5 PRKMK5 Homo sapiens (Human) 448 activation of MAPK activity [GO:0000187]; cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; ERK5 cascade [GO:0070375]; heart development [GO:0007507]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of interleukin-8 biosynthetic process [GO:0045415]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; signal transduction [GO:0007165] GO:0000122; GO:0000187; GO:0004672; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0007165; GO:0007507; GO:0030307; GO:0032088; GO:0034115; GO:0043154; GO:0045415; GO:0045944; GO:0046872; GO:0050679; GO:0051247; GO:0060761; GO:0070375; GO:0071363; GO:0071499; GO:0090051; GO:2000342; GO:2001240 0 0 0 PF00564;PF00069; Q14162 CHOYP_MEG10.25.91 m.33161 sp SREC_HUMAN 30.481 187 106 8 151 322 150 327 2.48E-11 69.3 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q1LZ53 CHOYP_DNM3A.1.1 m.44060 sp DNM3A_RAT 36.198 605 323 17 12 572 320 905 2.48E-117 372 DNM3A_RAT reviewed DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) Dnmt3a Rattus norvegicus (Rat) 908 "aging [GO:0007568]; cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; DNA methylation [GO:0006306]; DNA methylation involved in embryo development [GO:0043045]; DNA methylation involved in gamete generation [GO:0043046]; DNA methylation on cytosine [GO:0032776]; DNA methylation on cytosine within a CG sequence [GO:0010424]; hepatocyte apoptotic process [GO:0097284]; hypermethylation of CpG island [GO:0044027]; methylation-dependent chromatin silencing [GO:0006346]; mitotic cell cycle [GO:0000278]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of cell death [GO:0010942]; regulation of gene expression by genetic imprinting [GO:0006349]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethioninamine metabolic process [GO:0046499]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000278; GO:0000775; GO:0000791; GO:0001741; GO:0003677; GO:0003682; GO:0003886; GO:0005634; GO:0005654; GO:0005720; GO:0005737; GO:0006306; GO:0006346; GO:0006349; GO:0006351; GO:0007283; GO:0007568; GO:0009636; GO:0010212; GO:0010288; GO:0010424; GO:0010942; GO:0016363; GO:0030182; GO:0031667; GO:0032355; GO:0032776; GO:0033189; GO:0042220; GO:0042493; GO:0043045; GO:0043046; GO:0044027; GO:0045322; GO:0045471; GO:0046498; GO:0046499; GO:0046872; GO:0051718; GO:0071230; GO:0071361; GO:0071456; GO:0097284 0 0 0 PF00145;PF00855; Q28J59 CHOYP_BRAFLDRAFT_239751.2.3 m.36889 sp F221A_XENTR 57.045 291 106 4 7 297 3 274 2.48E-118 346 F221A_XENTR reviewed Protein FAM221A fam221a TNeu087m24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 295 0 0 0 0 0 PF14753; Q3TBT3 CHOYP_TMEM173.4.5 m.56469 sp STING_MOUSE 31.949 313 201 4 52 363 38 339 2.48E-45 162 STING_MOUSE reviewed Stimulator of interferon genes protein (mSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (MMITA) (Transmembrane protein 173) Tmem173 Eris Mita Mpys Sting Mus musculus (Mouse) 378 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0006915; GO:0008134; GO:0016021; GO:0019901; GO:0031625; GO:0032092; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042802; GO:0042803; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; Q3UWZ0 CHOYP_BRAFLDRAFT_88218.5.8 m.41642 sp TRI75_MOUSE 32.54 126 72 4 19 132 94 218 2.48E-07 56.6 TRI75_MOUSE reviewed Tripartite motif-containing protein 75 Trim75 Gm794 Mus musculus (Mouse) 467 0 GO:0005622; GO:0008270 0 0 0 PF13765;PF00622;PF00643; Q4V817 CHOYP_LOC764611.1.1 m.48336 sp CB068_XENLA 35.075 134 66 3 7 120 15 147 2.48E-15 70.9 CB068_XENLA reviewed UPF0561 protein C2orf68 homolog 0 Xenopus laevis (African clawed frog) 151 0 0 0 0 0 PF10573; Q5U220 CHOYP_LOC100373432.1.1 m.27024 sp TM254_RAT 36.207 116 70 3 5 116 8 123 2.48E-13 64.3 TM254_RAT reviewed Transmembrane protein 254 Tmem254 Rattus norvegicus (Rat) 123 0 GO:0016021 0 0 0 PF14934; Q6DIB5 CHOYP_LOC101072623.2.4 m.2634 sp MEG10_MOUSE 36.437 247 131 11 191 425 433 665 2.48E-25 114 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6P8C4 CHOYP_NHP2.1.1 m.57624 sp NHP2_XENTR 52.703 148 68 2 8 155 3 148 2.48E-49 158 NHP2_XENTR reviewed H/ACA ribonucleoprotein complex subunit 2-like protein (Nucleolar protein family A member 2-like protein) (snoRNP protein NHP2-like protein) nhp2 nola2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 149 cleavage involved in rRNA processing [GO:0000469]; maturation of LSU-rRNA [GO:0000470]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; translation [GO:0006412] GO:0000469; GO:0000470; GO:0005732; GO:0006412; GO:0030515; GO:0031118; GO:0031120; GO:0031429; GO:0034513 0 0 0 PF01248; Q6PB03 CHOYP_LOC659617.1.1 m.23473 sp PLD3_XENLA 52.696 408 182 7 71 474 78 478 2.48E-143 423 PLD3_XENLA reviewed Phospholipase D3 (PLD 3) (EC 3.1.4.4) (Choline phosphatase 3) (Phosphatidylcholine-hydrolyzing phospholipase D3) pld3 Xenopus laevis (African clawed frog) 493 lipid catabolic process [GO:0016042] GO:0004630; GO:0005789; GO:0016021; GO:0016042; GO:0070290 0 0 0 PF00614;PF13918; Q6TLE4 CHOYP_LOC100891486.2.2 m.59215 sp MMGT1_DANRE 50 104 51 1 19 122 5 107 2.48E-27 100 MMGT1_DANRE reviewed Membrane magnesium transporter 1 (ER membrane protein complex subunit 5) (Transmembrane protein 32) mmgt1 emc5 tmem32 zgc:92918 Danio rerio (Zebrafish) (Brachydanio rerio) 130 cation transmembrane transport [GO:0098655]; magnesium ion transport [GO:0015693] GO:0000139; GO:0005769; GO:0005794; GO:0005886; GO:0015095; GO:0015693; GO:0016021; GO:0022890; GO:0031901; GO:0072546; GO:0098655 0 0 0 PF10270; Q6YHK3 CHOYP_TRIADDRAFT_55768.1.2 m.4475 sp CD109_HUMAN 32.824 131 68 5 3 121 245 367 2.48E-08 54.3 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q6ZRF8 CHOYP_LOC100374974.12.16 m.47308 sp RN207_HUMAN 25 192 131 5 2 191 114 294 2.48E-10 66.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7SZT7 CHOYP_LOC659897.1.1 m.56562 sp ELAV4_XENLA 58.289 374 114 5 55 401 38 396 2.48E-144 419 ELAV4_XENLA reviewed ELAV-like protein 4 (Protein ElrD) elavl4 elrD Xenopus laevis (African clawed frog) 400 multicellular organism development [GO:0007275] GO:0000166; GO:0003723; GO:0007275; GO:0030529 0 0 0 PF00076; Q86IV5 CHOYP_BRAFLDRAFT_117811.1.1 m.27127 sp CTNA_DICDI 38.073 218 123 3 47 263 17 223 2.48E-41 145 CTNA_DICDI reviewed Countin-1 ctnA DDB_G0274597 Dictyostelium discoideum (Slime mold) 258 actin filament polymerization [GO:0030041]; cell motility [GO:0048870]; glucose homeostasis [GO:0042593]; multicellular organism development [GO:0007275]; negative regulation of aggregate size involved in sorocarp development [GO:0031158]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cGMP biosynthetic process [GO:0030827]; regulation of glucose-6-phosphatase activity [GO:0032114]; regulation of glycolytic process [GO:0006110] GO:0004871; GO:0005576; GO:0006110; GO:0007162; GO:0007275; GO:0030041; GO:0030827; GO:0031158; GO:0032114; GO:0042593; GO:0048870 0 0 0 0 Q8BTI8 CHOYP_LOC100372992.1.2 m.15611 sp SRRM2_MOUSE 54.206 214 90 6 50 261 1 208 2.48E-55 195 SRRM2_MOUSE reviewed Serine/arginine repetitive matrix protein 2 Srrm2 Kiaa0324 Mus musculus (Mouse) 2703 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0006397; GO:0008380; GO:0015030; GO:0016607; GO:0044822; GO:0071013 0 0 0 PF08312; Q8IWZ3 CHOYP_LOC583072.12.25 m.46533 sp ANKH1_HUMAN 31.498 327 172 13 580 870 349 659 2.48E-24 114 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8K0U4 CHOYP_BRAFLDRAFT_208293.20.20 m.66263 sp HS12A_MOUSE 29.73 629 359 16 2 569 68 674 2.48E-79 266 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N801 CHOYP_ITIH3.1.3 m.21736 sp CB061_HUMAN 40.465 215 112 8 69 276 37 242 2.48E-39 140 CB061_HUMAN reviewed Uncharacterized protein C2orf61 C2orf61 Homo sapiens (Human) 248 0 0 0 0 0 PF07004; Q8N801 CHOYP_LOC575504.1.1 m.59770 sp CB061_HUMAN 40.465 215 112 8 69 276 37 242 2.48E-39 140 CB061_HUMAN reviewed Uncharacterized protein C2orf61 C2orf61 Homo sapiens (Human) 248 0 0 0 0 0 PF07004; Q91V57 CHOYP_BRAFLDRAFT_219059.1.1 m.40578 sp CHIN_MOUSE 48.918 462 228 5 23 484 5 458 2.48E-162 471 CHIN_MOUSE reviewed N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) Chn1 Arhgap2 Mus musculus (Mouse) 459 ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; regulation of axonogenesis [GO:0050770]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0005737; GO:0008045; GO:0035556; GO:0043087; GO:0046872; GO:0046875; GO:0048013; GO:0050770; GO:0051056 0 0 0 PF00130;PF00620;PF00017; Q9ESN6 CHOYP_BRAFLDRAFT_69764.2.19 m.13474 sp TRIM2_MOUSE 30.392 204 127 8 97 293 536 731 2.48E-15 79.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HCU4 CHOYP_BRAFLDRAFT_133692.4.4 m.60767 sp CELR2_HUMAN 24.293 601 393 23 167 728 377 954 2.48E-21 104 CELR2_HUMAN reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) 2923 "dendrite morphogenesis [GO:0048813]; G-protein coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0007186; GO:0007283; GO:0016021; GO:0016055; GO:0021999; GO:0022407; GO:0048813; GO:0060071 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF12661;PF00053;PF02210; Q9JMG6 CHOYP_BRAFLDRAFT_130806.1.2 m.40021 sp TFPT_RAT 41.27 63 37 0 41 103 81 143 2.48E-13 71.2 TFPT_RAT reviewed TCF3 fusion partner homolog (Protein amida) Tfpt Amida Rattus norvegicus (Rat) 259 "apoptotic process [GO:0006915]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; positive regulation of apoptotic process [GO:0043065]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005737; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0006915; GO:0008584; GO:0019901; GO:0043065; GO:0046982 0 0 0 0 Q9NFT7 CHOYP_LOC657694.1.1 m.34526 sp HXK2_DROME 46.272 456 243 2 34 487 24 479 2.48E-152 446 HXK2_DROME reviewed Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) 486 cellular glucose homeostasis [GO:0001678]; fructose metabolic process [GO:0006000]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; mannose metabolic process [GO:0006013] GO:0001678; GO:0004340; GO:0004396; GO:0005524; GO:0005536; GO:0005829; GO:0006000; GO:0006006; GO:0006013; GO:0006096; GO:0008865; GO:0019158 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF00349;PF03727; Q9NGC3 CHOYP_CEG1A.3.6 m.28094 sp CEG1A_DROME 40.863 695 315 15 315 915 288 980 2.48E-146 462 CEG1A_DROME reviewed Centaurin-gamma-1A CenG1A CG31811 Drosophila melanogaster (Fruit fly) 995 medium-term memory [GO:0072375]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005096; GO:0005525; GO:0005622; GO:0007264; GO:0016020; GO:0043087; GO:0043547; GO:0046872; GO:0072375 0 0 0 PF01412;PF00071; Q9NRG9 CHOYP_LOC100366577.1.2 m.17884 sp AAAS_HUMAN 47.195 517 257 6 7 511 4 516 2.48E-164 479 AAAS_HUMAN reviewed Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) 546 fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; learning [GO:0007612]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of nucleocytoplasmic transport [GO:0046822]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005813; GO:0006406; GO:0006409; GO:0006913; GO:0007077; GO:0007612; GO:0009566; GO:0010827; GO:0015031; GO:0016020; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031965; GO:0046822; GO:0075733; GO:1900034 0 0 0 PF00400; Q9UBI4 CHOYP_LOC579579.1.1 m.51538 sp STML1_HUMAN 32.479 351 224 4 74 420 54 395 2.48E-61 207 STML1_HUMAN reviewed Stomatin-like protein 1 (SLP-1) (EPB72-like protein 1) (Protein unc-24 homolog) (Stomatin-related protein) (STORP) STOML1 SLP1 UNC24 MSTP019 Homo sapiens (Human) 398 0 GO:0016021 0 0 0 PF01145;PF02036; Q9Y219 CHOYP_BRAFLDRAFT_64071.33.35 m.52349 sp JAG2_HUMAN 41.667 60 35 0 4339 4398 353 412 2.48E-08 64.7 JAG2_HUMAN reviewed Protein jagged-2 (Jagged2) (hJ2) JAG2 Homo sapiens (Human) 1238 auditory receptor cell fate commitment [GO:0009912]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; epithelial cell apoptotic process involved in palatal shelf morphogenesis [GO:1990134]; gamma-delta T cell differentiation [GO:0042492]; in utero embryonic development [GO:0001701]; morphogenesis of embryonic epithelium [GO:0016331]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of cell proliferation [GO:0042127]; respiratory system process [GO:0003016]; skeletal system development [GO:0001501]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]; thymic T cell selection [GO:0045061] GO:0001501; GO:0001701; GO:0003016; GO:0005112; GO:0005509; GO:0005886; GO:0005887; GO:0007049; GO:0007219; GO:0007220; GO:0007283; GO:0008083; GO:0009912; GO:0016331; GO:0030154; GO:0030155; GO:0030217; GO:0030334; GO:0042127; GO:0042475; GO:0042492; GO:0045061; GO:0045747; GO:1990134 0 0 0 PF01414;PF00008;PF07645;PF12661;PF07657; Q9Y2M2 CHOYP_NEMVEDRAFT_V1G100491.1.1 m.7381 sp SSUH2_HUMAN 32.659 346 221 4 53 394 16 353 2.48E-60 202 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 B0XK69 CHOYP_SDHF2.1.1 m.229 sp SDHF2_CULQU 50.303 165 64 3 11 167 5 159 2.49E-49 159 SDHF2_CULQU reviewed "Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)" CPIJ019830 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) 159 "mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; protein-FAD linkage [GO:0018293]" GO:0005739; GO:0005759; GO:0006121; GO:0018293 0 0 0 PF03937; B5XBI1 CHOYP_BRAFLDRAFT_73148.1.1 m.19187 sp IF43A_SALSA 58 100 42 0 26 125 101 200 2.49E-33 118 IF43A_SALSA reviewed Intraflagellar transport protein 43 homolog A ift43a Salmo salar (Atlantic salmon) 207 cilium morphogenesis [GO:0060271]; intraciliary retrograde transport [GO:0035721] GO:0005929; GO:0030991; GO:0035721; GO:0060271 0 0 0 PF15305; D3YXG0 CHOYP_BRAFLDRAFT_88566.10.11 m.30321 sp HMCN1_MOUSE 34.465 383 201 16 5 361 4510 4868 2.49E-42 165 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O01814 CHOYP_FABP2.2.2 m.38813 sp FABP5_CAEEL 33.333 117 77 1 7 122 5 121 2.49E-13 65.1 FABP5_CAEEL reviewed Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans 136 0 GO:0005215; GO:0005504; GO:0005634; GO:0048471 0 0 0 PF00061; O35276 CHOYP_MUC5AC.1.2 m.17430 sp NRP2_RAT 43.226 155 80 4 3151 3298 277 430 2.49E-26 123 NRP2_RAT reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) Nrp2 Rattus norvegicus (Rat) 925 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; heart development [GO:0007507]; negative chemotaxis [GO:0050919]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649] GO:0001525; GO:0005021; GO:0007411; GO:0007507; GO:0008201; GO:0016021; GO:0017154; GO:0021612; GO:0021649; GO:0021828; GO:0030424; GO:0036486; GO:0046872; GO:0048846; GO:0050919; GO:0061549; GO:0061551; GO:0097374; GO:0097490; GO:0097491; GO:1901166; GO:1902285; GO:1903375; GO:1904835 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O35309 CHOYP_BRAFLDRAFT_74874.5.9 m.47033 sp NMI_MOUSE 30.556 144 85 4 392 522 160 301 2.49E-07 56.2 NMI_MOUSE reviewed N-myc-interactor (Nmi) (N-myc and STAT interactor) Nmi Mus musculus (Mouse) 314 interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha biosynthetic process [GO:0045355]; negative regulation of interferon-beta biosynthetic process [GO:0045358]; negative regulation of type I interferon production [GO:0032480]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003712; GO:0005654; GO:0005737; GO:0006366; GO:0032480; GO:0045355; GO:0045358; GO:0045824; GO:0060333; GO:1902524 0 0 0 PF07334;PF07292; O43301 CHOYP_HS12A.15.33 m.46723 sp HS12A_HUMAN 33.025 648 360 17 27 621 48 674 2.49E-97 315 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O54890 CHOYP_ITB1.2.4 m.24270 sp ITB3_MOUSE 35.433 762 452 23 27 766 38 781 2.49E-154 472 ITB3_MOUSE reviewed Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) Itgb3 Mus musculus (Mouse) 787 activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cell adhesion mediated by integrin [GO:0033627]; cell growth [GO:0016049]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell projection morphogenesis [GO:0048858]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045715]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of extracellular matrix organization [GO:1903053]; regulation of protein tyrosine kinase activity [GO:0061097]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; viral entry into host cell [GO:0046718] GO:0001938; GO:0001954; GO:0001968; GO:0002020; GO:0003756; GO:0004872; GO:0005178; GO:0005634; GO:0005886; GO:0005925; GO:0007044; GO:0007160; GO:0007229; GO:0008305; GO:0009897; GO:0009986; GO:0010595; GO:0010628; GO:0010745; GO:0010763; GO:0010888; GO:0014909; GO:0016049; GO:0016324; GO:0016477; GO:0019899; GO:0030168; GO:0030334; GO:0030335; GO:0031258; GO:0031527; GO:0031528; GO:0031589; GO:0032147; GO:0032369; GO:0032587; GO:0032956; GO:0033627; GO:0033690; GO:0034113; GO:0034446; GO:0034679; GO:0034683; GO:0035867; GO:0036120; GO:0038027; GO:0042470; GO:0042802; GO:0043184; GO:0043235; GO:0045672; GO:0045715; GO:0045780; GO:0046718; GO:0048008; GO:0048146; GO:0048858; GO:0050731; GO:0050748; GO:0050839; GO:0050840; GO:0050919; GO:0060055; GO:0061097; GO:0070062; GO:0070527; GO:0071133; GO:1900026; GO:1903053; GO:2000406 0 0 0 PF07974;PF08725;PF07965;PF00362; O70277 CHOYP_BRAFLDRAFT_87340.4.6 m.52738 sp TRIM3_RAT 26.712 146 103 3 41 183 599 743 2.49E-10 64.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88281 CHOYP_LOC579946.11.24 m.42367 sp MEGF6_RAT 31.362 947 551 41 219 1148 546 1410 2.49E-83 307 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O94827 CHOYP_PLEKHG5.1.3 m.11095 sp PKHG5_HUMAN 28.881 277 131 8 56 330 12 224 2.49E-22 101 PKHG5_HUMAN reviewed Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720) PLEKHG5 KIAA0720 Homo sapiens (Human) 1062 endothelial cell chemotaxis [GO:0035767]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004871; GO:0005085; GO:0005089; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0030027; GO:0030139; GO:0035023; GO:0035767; GO:0043065; GO:0043123; GO:0048471; GO:0051056 0 0 0 PF00621; O96790 CHOYP_IOV7.1.1 m.35982 sp DPGN_DIPMA 37.931 203 92 7 53 222 128 329 2.49E-29 115 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P04630 CHOYP_CDPK5.1.1 m.6214 sp CALL_CAEEL 35.606 132 78 2 71 195 25 156 2.49E-19 83.6 CALL_CAEEL reviewed Calmodulin-like protein cal-1 cmd-1 C13C12.1 Caenorhabditis elegans 161 0 GO:0005509 0 0 0 PF13499; P06276 CHOYP_LOC100371735.1.1 m.33649 sp CHLE_HUMAN 38.739 333 181 9 1 322 10 330 2.49E-57 202 CHLE_HUMAN reviewed Cholinesterase (EC 3.1.1.8) (Acylcholine acylhydrolase) (Butyrylcholine esterase) (Choline esterase II) (Pseudocholinesterase) BCHE CHE1 Homo sapiens (Human) 602 choline metabolic process [GO:0019695]; cocaine metabolic process [GO:0050783]; learning [GO:0007612]; negative regulation of cell proliferation [GO:0008285]; negative regulation of synaptic transmission [GO:0050805]; neuroblast differentiation [GO:0014016]; response to alkaloid [GO:0043279]; response to drug [GO:0042493]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384] GO:0001540; GO:0003824; GO:0003990; GO:0004104; GO:0005576; GO:0005641; GO:0005788; GO:0007612; GO:0008285; GO:0014016; GO:0016020; GO:0016788; GO:0019695; GO:0019899; GO:0033265; GO:0042493; GO:0042802; GO:0043279; GO:0050783; GO:0050805; GO:0051384; GO:0051593; GO:0072562 0 0 0 PF08674;PF00135; P12111 CHOYP_LOC100486063.5.9 m.39538 sp CO6A3_HUMAN 23.034 1615 1014 57 358 1904 27 1480 2.49E-84 313 CO6A3_HUMAN reviewed Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) 3177 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; muscle organ development [GO:0007517] GO:0004867; GO:0005576; GO:0005578; GO:0005589; GO:0005615; GO:0005788; GO:0007155; GO:0007517; GO:0030198; GO:0030574; GO:0031012; GO:0042383; GO:0070062; GO:1903561 0 0 0 PF01391;PF00014;PF00092; P12426 CHOYP_LOC583890.1.1 m.14405 sp APT_DROME 56.25 176 77 0 2 177 7 182 2.49E-61 191 APT_DROME reviewed Adenine phosphoribosyltransferase (APRT) (EC 2.4.2.7) Aprt CG18315 Drosophila melanogaster (Fruit fly) 182 adenine salvage [GO:0006168]; AMP salvage [GO:0044209] GO:0003999; GO:0005737; GO:0006168; GO:0044209 PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. 0 cd06223; PF00156; P12804 CHOYP_ANGP1.1.1 m.20178 sp FGL2_MOUSE 43.913 230 107 7 79 291 203 427 2.49E-50 174 FGL2_MOUSE reviewed Fibroleukin (Cytotoxic T-lymphocyte-specific protein) (Fibrinogen-like protein 2) (Prothrombinase) Fgl2 Fiblp Mus musculus (Mouse) 432 cytolysis [GO:0019835] GO:0008233; GO:0019835; GO:0070062 0 0 0 PF00147; P16157 CHOYP_TVAG_451090.11.13 m.64632 sp ANK1_HUMAN 37.591 274 171 0 1 274 283 556 2.49E-49 178 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P49355 CHOYP_FNTB.1.1 m.45546 sp FNTB_BOVIN 60 395 153 1 23 417 32 421 2.49E-168 482 FNTB_BOVIN reviewed Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) FNTB Bos taurus (Bovine) 437 negative regulation of cell proliferation [GO:0008285]; positive regulation of fibroblast proliferation [GO:0048146]; protein farnesylation [GO:0018343]; wound healing [GO:0042060] GO:0004311; GO:0004660; GO:0005965; GO:0008270; GO:0008285; GO:0018343; GO:0042060; GO:0048146 0 0 cd02893; PF00432; P70555 CHOYP_LOC658472.1.1 m.40565 sp PTH2R_RAT 29.845 258 160 7 13 262 12 256 2.49E-38 143 PTH2R_RAT reviewed Parathyroid hormone 2 receptor (PTH2 receptor) Pth2r Pthr2 Rattus norvegicus (Rat) 546 cell surface receptor signaling pathway [GO:0007166] GO:0004991; GO:0005886; GO:0007166; GO:0016021 0 0 0 PF00002;PF02793; Q01484 CHOYP_LOC100638883.3.3 m.36218 sp ANK2_HUMAN 32.338 201 135 1 260 460 586 785 2.49E-26 116 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q01520 CHOYP_EF1A1.1.1 m.50596 sp EF1A_PODAS 78.333 60 13 0 31 90 384 443 2.49E-24 99.4 EF1A_PODAS reviewed Elongation factor 1-alpha (EF-1-alpha) TEF AS4 Podospora anserina (Pleurage anserina) 460 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q11131 CHOYP_LOC100213495.2.2 m.51531 sp FUT7_MOUSE 33.333 114 63 4 78 186 121 226 2.49E-10 62 FUT7_MOUSE reviewed "Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase)" Fut7 Mus musculus (Mouse) 389 "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; leukocyte migration involved in immune response [GO:0002522]; protein glycosylation [GO:0006486]" GO:0002361; GO:0002522; GO:0006486; GO:0008417; GO:0016020; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q27874 CHOYP_PAT3.2.4 m.37275 sp PAT3_CAEEL 35.779 777 445 20 28 773 50 803 2.49E-143 449 PAT3_CAEEL reviewed Integrin beta pat-3 (Paralyzed arrest at two-fold protein 3) pat-3 ZK1058.2 Caenorhabditis elegans 809 cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]; muscle cell development [GO:0055001]; positive regulation of distal tip cell migration [GO:1903356]; positive regulation of locomotion [GO:0040017]; positive regulation of myosin II filament organization [GO:1904901]; positive regulation of ovulation [GO:0060279]; positive regulation of smooth muscle contraction [GO:0045987]; regulation of actin cytoskeleton organization [GO:0032956] GO:0007155; GO:0007229; GO:0008305; GO:0009986; GO:0031430; GO:0032956; GO:0040017; GO:0043005; GO:0043025; GO:0045987; GO:0055001; GO:0055120; GO:0060279; GO:1903356; GO:1904901 0 0 0 PF07974;PF08725;PF07965;PF00362; Q3SWT1 CHOYP_SOSB1.1.2 m.1668 sp SOSB1_RAT 52.632 114 52 1 1 114 40 151 2.49E-35 125 SOSB1_RAT reviewed SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) Nabp2 Obfc2b Ssb1 Rattus norvegicus (Rat) 211 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle checkpoint [GO:0007093]; response to ionizing radiation [GO:0010212] GO:0000724; GO:0003697; GO:0005634; GO:0006281; GO:0006974; GO:0007093; GO:0010212; GO:0070876 0 0 0 PF01336; Q3T0Y3 CHOYP_LOC100552374.1.1 m.21979 sp ST1B1_BOVIN 30.897 301 176 9 5 293 13 293 2.49E-37 137 ST1B1_BOVIN reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) 296 epithelial cell differentiation [GO:0030855]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005737; GO:0006805; GO:0008202; GO:0009812; GO:0030855; GO:0042403; GO:0051923 0 0 0 PF00685; Q4FZX0 CHOYP_LCHN.2.2 m.62586 sp LCHN_XENLA 60.154 389 152 1 188 573 46 434 2.49E-156 457 LCHN_XENLA reviewed Protein LCHN lchn Xenopus laevis (African clawed frog) 434 0 0 0 0 0 PF09804; Q4ZHG4 CHOYP_contig_032289 m.36887 sp FNDC1_HUMAN 41.406 128 71 3 198 324 1767 1891 2.49E-20 99.8 FNDC1_HUMAN reviewed Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein) FNDC1 FNDC2 KIAA1866 MEL4B3 Homo sapiens (Human) 1894 0 GO:0005576; GO:0005654 0 0 0 PF00041; Q5R5M4 CHOYP_BRAFLDRAFT_92063.2.2 m.33486 sp MOT9_PONAB 24.419 172 124 3 23 193 327 493 2.49E-12 68.6 MOT9_PONAB reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 509 0 GO:0005886; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q5UR67 CHOYP_NEK5.1.1 m.45205 sp RIBX_MIMIV 43.293 164 82 4 308 460 2 165 2.49E-31 122 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5ZK82 CHOYP_LOC100351251.1.1 m.9163 sp MPPE1_CHICK 45.833 360 184 5 24 376 20 375 2.49E-118 352 MPPE1_CHICK reviewed Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5) MPPE1 PGAP5 RCJMB04_12i13 Gallus gallus (Chicken) 398 ER to Golgi vesicle-mediated transport [GO:0006888]; GPI anchor biosynthetic process [GO:0006506] GO:0005654; GO:0005793; GO:0005794; GO:0005801; GO:0006506; GO:0006888; GO:0008081; GO:0016021; GO:0030145; GO:0033116; GO:0034235; GO:0070971 0 0 0 PF00149; Q60414 CHOYP_LOC591797.2.3 m.33686 sp NTCP2_CRIGR 32.333 300 197 3 139 436 30 325 2.49E-39 148 NTCP2_CRIGR reviewed "Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2)" SLC10A2 NTCP2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 348 0 GO:0008508; GO:0016021; GO:0016324 0 0 0 PF01758; Q6GNV7 CHOYP_TRIADDRAFT_60867.2.3 m.37598 sp DIRC2_XENLA 36.559 93 59 0 39 131 201 293 2.49E-14 71.6 DIRC2_XENLA reviewed Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) 456 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6P011 CHOYP_BRAFLDRAFT_126700.1.2 m.17812 sp EMC4_DANRE 54.438 169 73 3 6 172 21 187 2.49E-62 193 EMC4_DANRE reviewed ER membrane protein complex subunit 4 (Transmembrane protein 85) emc4 tmem85 zgc:77852 Danio rerio (Zebrafish) (Brachydanio rerio) 189 0 GO:0016021; GO:0072546 0 0 0 PF06417; Q6ZRF8 CHOYP_LOC100376608.3.4 m.51379 sp RN207_HUMAN 24.352 193 135 4 225 416 114 296 2.49E-10 67.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_LOC100378676.3.8 m.43012 sp RN207_HUMAN 22.973 222 155 7 16 235 103 310 2.49E-11 69.3 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8JZP3 CHOYP_KLHL2.1.3 m.45403 sp KLHL2_MOUSE 24.26 169 109 4 3 156 166 330 2.49E-09 61.6 KLHL2_MOUSE reviewed Kelch-like protein 2 Klhl2 Mus musculus (Mouse) 593 protein ubiquitination [GO:0016567] GO:0001725; GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0031463; GO:0042803 0 0 0 PF07707;PF00651;PF01344; Q8NFW1 CHOYP_LOC100931725.1.1 m.22065 sp COMA1_HUMAN 44.67 197 98 7 30 221 29 219 2.49E-36 139 COMA1_HUMAN reviewed Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) 1626 0 GO:0005576; GO:0005578; GO:0005581; GO:0005788 0 0 0 PF01391;PF00092; Q8TEW0 CHOYP_LOC100371218.1.3 m.21168 sp PARD3_HUMAN 39.516 744 369 21 3 725 1 684 2.49E-125 428 PARD3_HUMAN reviewed Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) 1356 asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell cycle [GO:0007049]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein complex assembly [GO:0006461]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein targeting to membrane [GO:0006612]; regulation of cellular localization [GO:0060341]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005546; GO:0005547; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005923; GO:0005938; GO:0006461; GO:0006612; GO:0007049; GO:0007163; GO:0007179; GO:0007205; GO:0007409; GO:0008356; GO:0010801; GO:0012505; GO:0022011; GO:0030054; GO:0031643; GO:0032266; GO:0033269; GO:0043025; GO:0043234; GO:0044295; GO:0060341; GO:0070830; GO:0090162 0 0 0 PF12053;PF00595; Q9CZP0 CHOYP_LOC100883090.1.1 m.49181 sp UFSP1_MOUSE 44.624 186 93 4 16 195 11 192 2.49E-44 149 UFSP1_MOUSE reviewed Ufm1-specific protease 1 (UfSP1) (EC 3.4.22.-) Ufsp1 D5Ertd655e Mus musculus (Mouse) 217 0 GO:0016790; GO:0070062; GO:0071567 0 0 0 PF07910; Q9HBM0 CHOYP_VEZT.3.3 m.56924 sp VEZA_HUMAN 29.773 440 261 15 1 409 179 601 2.49E-37 150 VEZA_HUMAN reviewed Vezatin VEZT Homo sapiens (Human) 779 single organismal cell-cell adhesion [GO:0016337] GO:0001669; GO:0005654; GO:0005737; GO:0005886; GO:0005912; GO:0016021; GO:0016337 0 0 0 PF12632; Q9NL98 CHOYP_ISCW_ISCW010532.4.4 m.62265 sp PRDX_ASCSU 74.359 195 50 0 1 195 1 195 2.49E-109 313 PRDX_ASCSU reviewed Peroxiredoxin (EC 1.11.1.15) (AsPrx) (Thioredoxin peroxidase) 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 195 cell redox homeostasis [GO:0045454]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005737; GO:0006979; GO:0008379; GO:0016209; GO:0045454 0 0 0 PF10417;PF00578; Q9NY25 CHOYP_NEMVEDRAFT_V1G154303.1.1 m.3521 sp CLC5A_HUMAN 28.125 128 79 4 17 143 70 185 2.49E-10 59.3 CLC5A_HUMAN reviewed C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) CLEC5A CLECSF5 MDL1 Homo sapiens (Human) 188 cellular defense response [GO:0006968]; innate immune response [GO:0045087]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myeloid cell apoptotic process [GO:0033033]; osteoblast development [GO:0002076]; positive regulation of cytokine secretion [GO:0050715]; signal transduction [GO:0007165] GO:0001618; GO:0002076; GO:0005886; GO:0005887; GO:0006968; GO:0007165; GO:0009986; GO:0030099; GO:0030246; GO:0033033; GO:0043066; GO:0045087; GO:0050715 0 0 0 PF00059; Q9VCA8 CHOYP_LOC100640442.8.10 m.64062 sp ANKHM_DROME 33.884 484 292 17 511 969 543 1023 2.49E-53 207 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VDT6 CHOYP_LOC656536.1.1 m.19361 sp MRM2_DROME 44.7 217 120 0 28 244 34 250 2.49E-61 196 MRM2_DROME reviewed "rRNA methyltransferase 2, mitochondrial (EC 2.1.1.-) (rRNA (uridine-2'-O)-methyltransferase)" CG11447 Drosophila melanogaster (Fruit fly) 250 enzyme-directed rRNA 2'-O-methylation [GO:0000453] GO:0000453; GO:0005739; GO:0008650 0 0 0 PF01728; A9VFD6 CHOYP_LOC100889562.1.1 m.27158 sp MTNK_BACWK 34.637 358 215 7 42 388 32 381 2.50E-53 184 MTNK_BACWK reviewed Methylthioribose kinase (MTR kinase) (EC 2.7.1.100) mtnK BcerKBAB4_3862 Bacillus weihenstephanensis (strain KBAB4) 392 L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; L-methionine biosynthetic process from S-adenosylmethionine [GO:0019284] GO:0005524; GO:0019284; GO:0019509; GO:0046522 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 2/2. {ECO:0000255|HAMAP-Rule:MF_01683}. 0 0 PF01636; B1WAX6 CHOYP_NEMVEDRAFT_V1G242088.2.2 m.50022 sp TIGAR_XENTR 43.885 139 75 3 31 167 12 149 2.50E-27 110 TIGAR_XENTR reviewed "Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator)" tigar Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 275 "apoptotic process [GO:0006915]; autophagy [GO:0006914]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 2,6-bisphosphate metabolic process [GO:0006003]" GO:0004083; GO:0004331; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0006003; GO:0006914; GO:0006915; GO:0016791; GO:0030388 0 0 cd07067; PF00300; D3ZD32 CHOYP_CHD5.1.2 m.18513 sp CHD5_RAT 50 72 35 1 90 161 125 195 2.50E-16 79 CHD5_RAT reviewed Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5) Chd5 Rattus norvegicus (Rat) 1948 "cerebral cortex neuron differentiation [GO:0021895]; histone H3-K27 trimethylation [GO:0098532]; histone H4 acetylation [GO:0043967]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; regulation of transcription involved in cell fate commitment [GO:0060850]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000792; GO:0003677; GO:0003682; GO:0005524; GO:0005634; GO:0006366; GO:0008026; GO:0008270; GO:0016581; GO:0021895; GO:0035093; GO:0043967; GO:0060850; GO:0061628; GO:0098532; GO:1901798 0 0 0 PF08074;PF08073;PF00385;PF06461;PF06465;PF00271;PF00628;PF00176; O07552 CHOYP_LOC754102.1.1 m.57575 sp NHAX_BACSU 25.466 161 102 4 8 151 7 166 2.50E-10 59.3 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O54879 CHOYP_CNOT1.1.1 m.12106 sp HMGB3_MOUSE 40.909 154 75 5 2 142 24 174 2.50E-22 91.7 HMGB3_MOUSE reviewed High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) Hmgb3 Hmg2a Hmg4 Mus musculus (Mouse) 200 "DNA geometric change [GO:0032392]; innate immune response [GO:0045087]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000400; GO:0003677; GO:0003723; GO:0005634; GO:0005694; GO:0005737; GO:0006351; GO:0006355; GO:0008301; GO:0032392; GO:0045087; GO:0045578; GO:0045638 0 0 0 PF00505;PF09011; O54879 CHOYP_LOC100912369.1.1 m.26620 sp HMGB3_MOUSE 40.909 154 75 5 2 142 24 174 2.50E-22 91.7 HMGB3_MOUSE reviewed High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) Hmgb3 Hmg2a Hmg4 Mus musculus (Mouse) 200 "DNA geometric change [GO:0032392]; innate immune response [GO:0045087]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000400; GO:0003677; GO:0003723; GO:0005634; GO:0005694; GO:0005737; GO:0006351; GO:0006355; GO:0008301; GO:0032392; GO:0045087; GO:0045578; GO:0045638 0 0 0 PF00505;PF09011; P04323 CHOYP_LOC578054.6.7 m.65021 sp POL3_DROME 41.553 438 241 7 1044 1473 193 623 2.50E-94 333 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P04755 CHOYP_LOC100533245.4.6 m.36947 sp ACH3_DROME 48.4 500 219 9 26 493 24 516 2.50E-144 427 ACH3_DROME reviewed Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) nAChRbeta1 Acr64B AcrD ard nAcRbeta-64B CG11348 Drosophila melanogaster (Fruit fly) 521 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P07768 CHOYP_SI.1.1 m.23110 sp SUIS_RABIT 37.179 78 42 3 10 85 914 986 2.50E-09 57 SUIS_RABIT reviewed "Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)]" SI Oryctolagus cuniculus (Rabbit) 1827 carbohydrate metabolic process [GO:0005975] GO:0004574; GO:0004575; GO:0005975; GO:0016021; GO:0016324; GO:0030246 0 0 cd00111; PF01055;PF16863;PF00088; P0AF48 CHOYP_LOC100199222.1.1 m.17588 sp YJBQ_ECOLI 44.526 137 76 0 9 145 1 137 2.50E-46 150 YJBQ_ECOLI reviewed UPF0047 protein YjbQ yjbQ b4056 JW4017 Escherichia coli (strain K12) 138 0 0 0 0 0 PF01894; P18700 CHOYP_LOC100367715.1.1 m.65921 sp TBB_STRPU 94.545 110 6 0 1 110 78 187 2.50E-73 222 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P20693 CHOYP_BRAFLDRAFT_66146.1.1 m.16416 sp FCER2_MOUSE 33.333 153 82 6 95 241 193 331 2.50E-15 77.4 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P29694 CHOYP_EF1G.2.3 m.50676 sp EF1G_RABIT 60.638 188 65 3 8 187 251 437 2.50E-79 245 EF1G_RABIT reviewed Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) EEF1G Oryctolagus cuniculus (Rabbit) 437 0 GO:0003746 0 0 0 PF00647;PF00043;PF02798; P31696 CHOYP_PHUM_PHUM498630.2.3 m.47217 sp AGRIN_CHICK 33.508 764 450 22 881 1607 1326 2068 2.50E-115 408 AGRIN_CHICK reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Gallus gallus (Chicken) 2081 actin cytoskeleton reorganization [GO:0031532]; brain development [GO:0007420]; cell differentiation [GO:0030154]; extracellular matrix organization [GO:0030198]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; nervous system development [GO:0007399]; neuromuscular junction development [GO:0007528]; neuron cell-cell adhesion [GO:0007158]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113] GO:0002162; GO:0004708; GO:0004714; GO:0004872; GO:0005509; GO:0005539; GO:0005576; GO:0005605; GO:0005622; GO:0005886; GO:0007158; GO:0007213; GO:0007399; GO:0007420; GO:0007528; GO:0008201; GO:0016021; GO:0030054; GO:0030154; GO:0030198; GO:0030297; GO:0030424; GO:0030548; GO:0031012; GO:0031532; GO:0031594; GO:0033691; GO:0035374; GO:0043005; GO:0043113; GO:0043236; GO:0043237; GO:0043395; GO:0043547; GO:0045121; GO:0045202; GO:0045887; GO:0045944; GO:0050840; GO:0051491 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF03146;PF01390; P42297 CHOYP_LOC100174996.1.1 m.27300 sp YXIE_BACSU 27.586 145 97 4 4 141 5 148 2.50E-09 55.5 YXIE_BACSU reviewed Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) 148 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P62510 CHOYP_ERR3.1.1 m.25316 sp ERR3_RAT 52.035 344 153 6 99 440 123 456 2.50E-117 353 ERR3_RAT reviewed Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3) Esrrg Errg Nr3b3 Rattus norvegicus (Rat) 458 "positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000977; GO:0001228; GO:0003707; GO:0003708; GO:0005496; GO:0005634; GO:0006355; GO:0008270; GO:0045893; GO:0050682 0 0 0 PF00104;PF00105; P70318 CHOYP_LOC659024.1.2 m.31136 sp TIAR_MOUSE 52.105 380 148 8 1 378 1 348 2.50E-118 352 TIAR_MOUSE reviewed Nucleolysin TIAR (TIA-1-related protein) Tial1 Mus musculus (Mouse) 392 apoptotic process [GO:0006915]; germ cell development [GO:0007281]; positive regulation of cell proliferation [GO:0008284]; stem cell division [GO:0017145] GO:0000166; GO:0005634; GO:0005737; GO:0006915; GO:0007281; GO:0008284; GO:0010494; GO:0017091; GO:0017145; GO:0044822; GO:0070062 0 0 0 PF00076; Q04786 CHOYP_NEMVEDRAFT_V1G201552.1.6 m.2876 sp HEX_VIBVL 35.584 874 479 25 186 1013 7 842 2.50E-158 496 HEX_VIBVL reviewed Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus 847 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; Q27421 CHOYP_GOGB1.1.2 m.26408 sp OSP_DROME 55.422 166 62 3 5 160 39 202 2.50E-51 204 OSP_DROME reviewed Protein outspread osp CG3479 Drosophila melanogaster (Fruit fly) 1566 0 0 0 0 0 PF00169; Q460N3 CHOYP_PARP14.18.22 m.53663 sp PAR15_HUMAN 27.273 187 130 3 532 714 75 259 2.50E-16 87 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q460N5 CHOYP_PAR15.5.6 m.60633 sp PAR14_HUMAN 27.504 589 379 14 66 632 809 1371 2.50E-51 200 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4R5P1 CHOYP_RAB8A.1.3 m.5988 sp RAB8A_MACFA 76.382 199 45 2 14 211 10 207 2.50E-109 315 RAB8A_MACFA reviewed Ras-related protein Rab-8A RAB8A QccE-11745 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 207 axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0042384]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005794; GO:0005814; GO:0005886; GO:0005929; GO:0007264; GO:0007409; GO:0015031; GO:0017137; GO:0019003; GO:0030670; GO:0032869; GO:0042384; GO:0045335; GO:0055038; GO:0072659 0 0 0 PF00071; Q4R7U0 CHOYP_LOC100078129.1.1 m.5013 sp TMC7_MACFA 32.682 563 314 14 24 575 49 557 2.50E-93 304 TMC7_MACFA reviewed Transmembrane channel-like protein 7 TMC7 QtsA-14390 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 723 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q54KA7 CHOYP_AFUA_1G01020.39.50 m.54484 sp SECG_DICDI 35.048 311 185 3 1 295 218 527 2.50E-46 170 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5RA42 CHOYP_LOC100117365.1.1 m.37817 sp IF1AX_PONAB 74.286 105 16 2 1 105 36 129 2.50E-46 148 IF1AX_PONAB reviewed "Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)" EIF1AX Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 144 0 GO:0003743; GO:0044822 0 0 0 PF01176; Q5RE33 CHOYP_LOC101075808.1.1 m.17712 sp REEP5_PONAB 55.429 175 74 1 13 183 6 180 2.50E-69 213 REEP5_PONAB reviewed Receptor expression-enhancing protein 5 (Polyposis locus protein 1 homolog) REEP5 DP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 189 0 GO:0016021 0 0 0 PF03134; Q6DE37 CHOYP_LOC658303.1.1 m.27612 sp GXLT2_XENLA 47.238 362 167 5 30 378 55 405 2.50E-114 342 GXLT2_XENLA reviewed Glucoside xylosyltransferase 2 (EC 2.4.2.n2) (Glycosyltransferase 8 domain-containing protein 4) gxylt2 glt8d4 Xenopus laevis (African clawed frog) 423 O-glycan processing [GO:0016266] GO:0016021; GO:0016266; GO:0035252 0 0 0 PF01501; Q6GLQ4 CHOYP_PP1RA.1.1 m.9915 sp PP1RA_XENLA 42.481 266 135 6 498 754 382 638 2.50E-42 169 PP1RA_XENLA reviewed Serine/threonine-protein phosphatase 1 regulatory subunit 10 ppp1r10 Xenopus laevis (African clawed frog) 819 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004864; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF08711; Q6INI7 CHOYP_NIT2B.1.1 m.18389 sp NIT2B_XENLA 71.863 263 74 0 1 263 4 266 2.50E-148 418 NIT2B_XENLA reviewed Omega-amidase NIT2-B (EC 3.5.1.3) (Nitrilase homolog 2) nit2b Xenopus laevis (African clawed frog) 276 nitrogen compound metabolic process [GO:0006807] GO:0005737; GO:0006807; GO:0050152 0 0 0 PF00795; Q7Z5L3 CHOYP_LRRX1.6.11 m.41895 sp C1QL2_HUMAN 36.601 153 76 5 578 723 149 287 2.50E-14 77.4 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q8C9A2 CHOYP_LOC100376351.1.1 m.14820 sp ENDOV_MOUSE 51.055 237 110 4 55 290 17 248 2.50E-83 257 ENDOV_MOUSE reviewed Endonuclease V (EC 3.1.26.-) Endov Mus musculus (Mouse) 338 DNA repair [GO:0006281] GO:0000287; GO:0003727; GO:0005730; GO:0005737; GO:0006281; GO:0016888; GO:0016891; GO:0043566 0 0 cd06559; PF04493; Q8CD19 CHOYP_BRAFLDRAFT_76662.1.3 m.36720 sp LANC3_MOUSE 44 425 214 7 3 414 5 418 2.50E-114 343 LANC3_MOUSE reviewed LanC-like protein 3 Lancl3 Mus musculus (Mouse) 420 signal transduction [GO:0007165] GO:0003824; GO:0005886; GO:0007165 0 0 0 PF05147; Q8CH02 CHOYP_A4.3.3 m.22262 sp SUGP1_MOUSE 45.885 401 158 7 654 1003 251 643 2.50E-107 350 SUGP1_MOUSE reviewed SURP and G-patch domain-containing protein 1 (Splicing factor 4) Sugp1 Sf4 Mus musculus (Mouse) 643 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0008380; GO:0044822 0 0 0 PF01585;PF01805; Q8MPM1 CHOYP_GELS2.1.2 m.25226 sp GELS2_LUMTE 40.594 101 55 2 3 101 251 348 2.50E-19 84.7 GELS2_LUMTE reviewed Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) 366 actin filament capping [GO:0051693] GO:0005737; GO:0005856; GO:0051693 0 0 0 PF00626; Q8N5A5 CHOYP_LOC100183847.2.2 m.17646 sp ZGPAT_HUMAN 33.624 574 321 14 1 557 1 531 2.50E-90 290 ZGPAT_HUMAN reviewed Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) ZGPAT GPATC6 GPATCH6 KIAA1847 ZC3H9 ZC3HDC9 ZIP Homo sapiens (Human) 531 "negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000978; GO:0001078; GO:0003700; GO:0005634; GO:0006351; GO:0007175; GO:0043565; GO:0045892; GO:0046872 0 0 0 PF01585; Q8N5A5 CHOYP_LOC100183847.2.2 m.17647 sp ZGPAT_HUMAN 33.624 574 321 14 1 557 1 531 2.50E-90 290 ZGPAT_HUMAN reviewed Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein) ZGPAT GPATC6 GPATCH6 KIAA1847 ZC3H9 ZC3HDC9 ZIP Homo sapiens (Human) 531 "negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000978; GO:0001078; GO:0003700; GO:0005634; GO:0006351; GO:0007175; GO:0043565; GO:0045892; GO:0046872 0 0 0 PF01585; Q8NEF3 CHOYP_CC112.2.2 m.45019 sp CC112_HUMAN 52.778 108 51 0 3 110 335 442 2.50E-31 117 CC112_HUMAN reviewed Coiled-coil domain-containing protein 112 (Mutated in bladder cancer protein 1) CCDC112 MBC1 Homo sapiens (Human) 446 0 0 0 0 0 0 Q8WZ60 CHOYP_BTBD1.1.1 m.23657 sp KLHL6_HUMAN 45.455 55 29 1 46 99 197 251 2.50E-07 50.8 KLHL6_HUMAN reviewed Kelch-like protein 6 KLHL6 Homo sapiens (Human) 621 B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467] GO:0002467; GO:0050853 0 0 0 PF07707;PF00651;PF01344; Q90YS3 CHOYP_contig_052259 m.62598 sp RS2_ICTPU 82.353 119 21 0 45 163 32 150 2.50E-63 199 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q99NH0 CHOYP_LOC762964.10.10 m.64199 sp ANR17_MOUSE 30.603 464 249 16 154 609 232 630 2.50E-37 152 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9D1D4 CHOYP_TMEDA.1.2 m.42794 sp TMEDA_MOUSE 69.652 201 55 2 10 206 21 219 2.50E-97 285 TMEDA_MOUSE reviewed Transmembrane emp24 domain-containing protein 10 (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1) Tmed10 Tmp21 Mus musculus (Mouse) 219 "COPI-coated vesicle budding [GO:0035964]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; kidney development [GO:0001822]; protein oligomerization [GO:0051259]; regulated exocytosis [GO:0045055]; regulation of beta-amyloid formation [GO:1902003]; response to alkaloid [GO:0043279]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle targeting, to, from or within Golgi [GO:0048199]" GO:0000139; GO:0001822; GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0005801; GO:0005886; GO:0006886; GO:0006890; GO:0007030; GO:0016021; GO:0019905; GO:0030137; GO:0030140; GO:0030658; GO:0030667; GO:0033116; GO:0035964; GO:0042470; GO:0042589; GO:0043279; GO:0045055; GO:0048199; GO:0051259; GO:0070062; GO:0070765; GO:1902003 0 0 0 PF01105; Q9ESN6 CHOYP_LOC100374741.64.83 m.53324 sp TRIM2_MOUSE 26.087 230 153 6 294 519 514 730 2.50E-11 70.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H477 CHOYP_RBSK.1.1 m.17187 sp RBSK_HUMAN 49.834 301 150 1 26 325 22 322 2.50E-98 296 RBSK_HUMAN reviewed Ribokinase (RK) (EC 2.7.1.15) RBKS RBSK Homo sapiens (Human) 322 D-ribose catabolic process [GO:0019303] GO:0004747; GO:0005524; GO:0005634; GO:0005737; GO:0019303; GO:0046872; GO:0070062 PATHWAY: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03215}. 0 cd01174; PF00294; Q9JLC4 CHOYP_NEMVEDRAFT_V1G245806.1.1 m.55229 sp SORC1_MOUSE 31.02 980 612 29 79 1032 157 1098 2.50E-136 446 SORC1_MOUSE reviewed VPS10 domain-containing receptor SorCS1 (mSorCS) Sorcs1 Sorcs Mus musculus (Mouse) 1167 0 GO:0016020; GO:0016021 0 0 0 PF00801;PF15902;PF15901; Q9P2F6 CHOYP_NEMVEDRAFT_V1G209966.1.1 m.26141 sp RHG20_HUMAN 35.458 612 353 14 411 1003 38 626 2.50E-99 352 RHG20_HUMAN reviewed Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) 1191 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00788;PF00620; Q9ULJ7 CHOYP_LOC753709.34.44 m.59592 sp ANR50_HUMAN 30.933 611 398 19 127 715 494 1102 2.50E-58 218 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A4QNN3 CHOYP_LOC100377876.1.2 m.48889 sp UBP30_XENTR 36.285 463 227 12 66 498 80 504 2.51E-74 246 UBP30_XENTR reviewed Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) usp30 TEgg099b09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 519 mitochondrial fusion [GO:0008053]; mitophagy [GO:0000422]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000422; GO:0004197; GO:0004843; GO:0005739; GO:0005741; GO:0006511; GO:0008053; GO:0016021; GO:0016579; GO:0035871; GO:0044313 0 0 0 PF00443; A6H782 CHOYP_TEKT5.1.1 m.60031 sp TEKT3_BOVIN 55.839 274 121 0 44 317 216 489 2.51E-107 324 TEKT3_BOVIN reviewed Tektin-3 TEKT3 Bos taurus (Bovine) 490 cilium morphogenesis [GO:0060271]; regulation of fertilization [GO:0080154]; sperm motility [GO:0030317] GO:0002080; GO:0005874; GO:0030317; GO:0036126; GO:0060271; GO:0080154 0 0 0 0 A6NNF4 CHOYP_LOC571721.2.3 m.53122 sp ZN726_HUMAN 28.926 605 371 14 550 1150 156 705 2.51E-54 206 ZN726_HUMAN reviewed Zinc finger protein 726 ZNF726 Homo sapiens (Human) 738 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; O60218 CHOYP_CRE_18961.1.1 m.30942 sp AK1BA_HUMAN 52.632 114 54 0 6 119 3 116 2.51E-32 119 AK1BA_HUMAN reviewed Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) AKR1B10 AKR1B11 Homo sapiens (Human) 316 cellular aldehyde metabolic process [GO:0006081]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202] GO:0001523; GO:0001758; GO:0004033; GO:0005764; GO:0005829; GO:0006081; GO:0007586; GO:0008202; GO:0016488; GO:0044597; GO:0044598; GO:0045550; GO:0047718; GO:0070062 0 0 cd06660; PF00248; O75179 CHOYP_LOC583072.5.25 m.32530 sp ANR17_HUMAN 28.545 536 327 19 73 592 222 717 2.51E-38 156 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_TRIM2.29.59 m.35687 sp TRIM3_HUMAN 22.095 783 461 29 10 739 22 708 2.51E-14 80.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O95864 CHOYP_FADS2.2.2 m.50697 sp FADS2_HUMAN 50.877 114 42 2 1 100 1 114 2.51E-31 117 FADS2_HUMAN reviewed Fatty acid desaturase 2 (EC 1.14.19.3) (Acyl-CoA 6-desaturase) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) FADS2 Homo sapiens (Human) 444 alpha-linolenic acid metabolic process [GO:0036109]; linoleic acid metabolic process [GO:0043651]; unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005789; GO:0005887; GO:0006636; GO:0016020; GO:0016213; GO:0036109; GO:0043651 PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. 0 0 PF00173;PF00487; P10586 CHOYP_PTPRC.14.14 m.62305 sp PTPRF_HUMAN 39.506 243 137 6 74 310 1332 1570 2.51E-48 177 PTPRF_HUMAN reviewed Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) PTPRF LAR Homo sapiens (Human) 1907 cell adhesion [GO:0007155]; cell migration [GO:0016477]; chemical synaptic transmission [GO:0007268]; negative regulation of receptor binding [GO:1900121]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0004725; GO:0005001; GO:0005886; GO:0005887; GO:0007155; GO:0007185; GO:0007268; GO:0008201; GO:0016477; GO:0031102; GO:0035335; GO:0035373; GO:0043005; GO:0043025; GO:0048679; GO:0070062; GO:1900121 0 0 0 PF00041;PF07679;PF00102; P29693 CHOYP_LOC100185469.2.2 m.49998 sp EF1D_XENLA 68.478 92 29 0 4 95 148 239 2.51E-41 140 EF1D_XENLA reviewed Elongation factor 1-delta (EF-1-delta) (P36) eef1d Xenopus laevis (African clawed frog) 265 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P52333 CHOYP_MONBRDRAFT_44336.2.2 m.45666 sp JAK3_HUMAN 28.405 602 371 19 977 1552 524 1091 2.51E-56 218 JAK3_HUMAN reviewed Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) JAK3 Homo sapiens (Human) 1124 adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; cell migration [GO:0016477]; enzyme linked receptor protein signaling pathway [GO:0007167]; innate immune response [GO:0045087]; interleukin-4-mediated signaling pathway [GO:0035771]; intracellular signal transduction [GO:0035556]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; MAPK cascade [GO:0000165]; negative regulation of dendritic cell cytokine production [GO:0002731]; negative regulation of FasL biosynthetic process [GO:0045221]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of thymocyte apoptotic process [GO:0070244]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of immune response [GO:0050778]; positive regulation of T cell proliferation [GO:0042102]; protein phosphorylation [GO:0006468]; regulation of T cell apoptotic process [GO:0070232]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-9 [GO:0071104]; STAT protein import into nucleus [GO:0007262]; T cell homeostasis [GO:0043029]; tyrosine phosphorylation of Stat5 protein [GO:0042506]; tyrosine phosphorylation of STAT protein [GO:0007260] GO:0000165; GO:0002250; GO:0002731; GO:0004713; GO:0004715; GO:0005088; GO:0005102; GO:0005524; GO:0005829; GO:0005856; GO:0006468; GO:0007167; GO:0007204; GO:0007260; GO:0007262; GO:0012505; GO:0016477; GO:0018108; GO:0019903; GO:0030183; GO:0031234; GO:0032693; GO:0032695; GO:0035556; GO:0035771; GO:0038083; GO:0042102; GO:0042104; GO:0042506; GO:0043029; GO:0045087; GO:0045221; GO:0045626; GO:0050778; GO:0050868; GO:0051928; GO:0060397; GO:0070232; GO:0070244; GO:0070669; GO:0070670; GO:0070672; GO:0071104 0 0 0 PF07714; P86221 CHOYP_TUB1.1.1 m.3493 sp TBB4B_MESAU 98.684 152 2 0 1 152 1 152 2.51E-110 318 TBB4B_MESAU reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) 290 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091; Q03348 CHOYP_LOC101166342.1.1 m.54301 sp PTPRA_RAT 26.933 375 242 15 53 401 127 495 2.51E-30 127 PTPRA_RAT reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) 796 oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714] GO:0004725; GO:0005886; GO:0016021; GO:0032403; GO:0043231; GO:0048709; GO:0048714 0 0 0 PF00102; Q03348 CHOYP_PTPRA.16.22 m.53470 sp PTPRA_RAT 29.167 744 471 22 368 1085 81 794 2.51E-81 285 PTPRA_RAT reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) 796 oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714] GO:0004725; GO:0005886; GO:0016021; GO:0032403; GO:0043231; GO:0048709; GO:0048714 0 0 0 PF00102; Q3V0L5 CHOYP_BRAFLDRAFT_125356.1.3 m.14090 sp LRC43_MOUSE 34.674 522 287 12 11 497 27 529 2.51E-69 243 LRC43_MOUSE reviewed Leucine-rich repeat-containing protein 43 Lrrc43 Gm1061 Mus musculus (Mouse) 667 0 0 0 0 0 0 Q502K2 CHOYP_SAMH1.1.12 m.2732 sp SAMH1_DANRE 55.187 482 197 6 57 520 93 573 2.51E-178 518 SAMH1_DANRE reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) 622 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966;PF07647; Q502M6 CHOYP_TVAG_451090.2.13 m.21063 sp ANR29_DANRE 37.931 116 72 0 1 116 92 207 2.51E-21 89 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q58CP0 CHOYP_LOC100371176.1.1 m.33995 sp IDH3G_BOVIN 58.772 342 139 2 43 383 43 383 2.51E-150 434 IDH3G_BOVIN reviewed "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma)" IDH3G Bos taurus (Bovine) 392 isocitrate metabolic process [GO:0006102]; tricarboxylic acid cycle [GO:0006099] GO:0000287; GO:0004449; GO:0005524; GO:0005654; GO:0005730; GO:0005739; GO:0006099; GO:0006102; GO:0051287 0 0 0 PF00180; Q5EAR5 CHOYP_BRAFLDRAFT_202318.1.1 m.4331 sp TRPT1_DANRE 48.404 188 90 4 1 184 40 224 2.51E-55 189 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q5EB73 CHOYP_NEMVEDRAFT_V1G81504.1.1 m.62038 sp TM246_RAT 30.89 382 246 8 18 394 27 395 2.51E-47 169 TM246_RAT reviewed Transmembrane protein 246 Tmem246 Rattus norvegicus (Rat) 403 0 GO:0016021 0 0 0 0 Q5RHP9 CHOYP_LOC100179357.2.6 m.16786 sp ERIC3_HUMAN 34.956 452 219 10 1 432 1 397 2.51E-67 255 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q61555 CHOYP_BRAFLDRAFT_88050.2.2 m.57970 sp FBN2_MOUSE 38.851 296 161 9 73 360 1205 1488 2.51E-47 176 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q6INQ6 CHOYP_SLC25A46.1.1 m.23076 sp S246A_XENLA 34.737 95 54 2 22 109 60 153 2.51E-11 62.4 S246A_XENLA reviewed Solute carrier family 25 member 46-A slc25a46-a Xenopus laevis (African clawed frog) 417 mitochondrial membrane fission [GO:0090149]; transport [GO:0006810] GO:0005741; GO:0006810; GO:0016021; GO:0090149 0 0 0 PF00153; Q6P7Q4 CHOYP_GLO1.1.1 m.32382 sp LGUL_RAT 68.927 177 55 0 2 178 7 183 2.51E-95 277 LGUL_RAT reviewed Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase) Glo1 Rattus norvegicus (Rat) 184 carbohydrate metabolic process [GO:0005975]; glutathione metabolic process [GO:0006749]; methylglyoxal metabolic process [GO:0009438]; negative regulation of apoptotic process [GO:0043066]; osteoclast differentiation [GO:0030316]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0004462; GO:0005975; GO:0006357; GO:0006749; GO:0008270; GO:0009438; GO:0030316; GO:0043066; GO:0070062 PATHWAY: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2. 0 0 PF00903; Q6PK81 CHOYP_LOC100892461.2.2 m.55369 sp ZN773_HUMAN 42.035 226 126 5 461 685 214 435 2.51E-47 177 ZN773_HUMAN reviewed Zinc finger protein 773 (Zinc finger protein 419B) ZNF773 ZNF419B Homo sapiens (Human) 442 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q7Z5L3 CHOYP_LOC100378602.1.1 m.44262 sp C1QL2_HUMAN 31.061 132 83 3 293 422 160 285 2.51E-08 58.5 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q7ZUB3 CHOYP_LOC100867334.1.1 m.33475 sp TSN31_DANRE 48.43 223 104 2 1 223 1 212 2.51E-70 216 TSN31_DANRE reviewed Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence homolog) tspan31 sas zgc:56710 Danio rerio (Zebrafish) (Brachydanio rerio) 212 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q7ZUW2 CHOYP_HYOU1.1.3 m.163 sp HYOU1_DANRE 41.018 334 170 7 4 313 433 763 2.51E-57 202 HYOU1_DANRE reviewed Hypoxia up-regulated protein 1 hyou1 Danio rerio (Zebrafish) (Brachydanio rerio) 980 0 GO:0005524; GO:0005788 0 0 0 PF00012; Q7ZVP8 CHOYP_ISCW_ISCW018083.1.1 m.1650 sp TM38B_DANRE 32.74 281 177 4 8 286 11 281 2.51E-53 178 TM38B_DANRE reviewed Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B) tmem38b zgc:55815 Danio rerio (Zebrafish) (Brachydanio rerio) 289 0 GO:0005267; GO:0005789; GO:0016021 0 0 0 PF05197; Q7ZYA5 CHOYP_LOC100373584.1.1 m.6647 sp PRKAA_XENLA 37.654 324 147 7 6 320 28 305 2.51E-60 198 PRKAA_XENLA reviewed Interferon-inducible double-stranded RNA-dependent protein kinase activator A homolog A prkra-a prkra Xenopus laevis (African clawed frog) 309 production of siRNA involved in RNA interference [GO:0030422] GO:0003725; GO:0005634; GO:0005737; GO:0008047; GO:0030422; GO:0048471 0 0 0 PF00035;PF16482; Q8BRK8 CHOYP_AGAP_AGAP002686.1.1 m.5987 sp AAPK2_MOUSE 52.885 104 47 1 1 102 244 347 2.51E-32 121 AAPK2_MOUSE reviewed 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) Prkaa2 Mus musculus (Mouse) 552 "autophagy [GO:0006914]; cellular response to drug [GO:0035690]; cellular response to glucose starvation [GO:0042149]; cellular response to nutrient levels [GO:0031669]; cellular response to prostaglandin E stimulus [GO:0071380]; cholesterol biosynthetic process [GO:0006695]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; lipid biosynthetic process [GO:0008610]; membrane organization [GO:0061024]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of TOR signaling [GO:0032007]; positive regulation of autophagy [GO:0010508]; positive regulation of glycolytic process [GO:0045821]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of energy homeostasis [GO:2000505]; regulation of gene expression [GO:0010468]; regulation of macroautophagy [GO:0016241]; regulation of transcription, DNA-templated [GO:0006355]; response to muscle activity [GO:0014850]; response to stress [GO:0006950]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0003682; GO:0004674; GO:0004679; GO:0004712; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006468; GO:0006633; GO:0006695; GO:0006914; GO:0006950; GO:0007005; GO:0008610; GO:0010468; GO:0010508; GO:0014850; GO:0016055; GO:0016241; GO:0031588; GO:0031669; GO:0032007; GO:0035174; GO:0035690; GO:0042149; GO:0042593; GO:0042752; GO:0043066; GO:0045821; GO:0046872; GO:0047322; GO:0048511; GO:0050405; GO:0055089; GO:0061024; GO:0071380; GO:2000505 0 0 0 PF16579;PF00069; Q92193 CHOYP_ACT2.1.3 m.10933 sp ACT_CRAVI 97.196 107 3 0 1 107 36 142 2.51E-71 216 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q99973 CHOYP_BRAFLDRAFT_128562.3.4 m.56347 sp TEP1_HUMAN 27.374 1432 893 42 4 1378 1281 2622 2.51E-130 450 TEP1_HUMAN reviewed Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) 2627 telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000781; GO:0002039; GO:0003720; GO:0003723; GO:0005524; GO:0005697; GO:0005737; GO:0016363; GO:0019899; GO:0030529; GO:0070034 0 0 0 PF13271;PF05386;PF05731;PF00400; Q9CY58 CHOYP_LOC100661020.2.5 m.23368 sp PAIRB_MOUSE 55.769 52 21 1 1 52 287 336 2.51E-08 54.3 PAIRB_MOUSE reviewed Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1) Serbp1 Pairbp1 Mus musculus (Mouse) 407 regulation of apoptotic process [GO:0042981] GO:0003730; GO:0005634; GO:0005737; GO:0005886; GO:0016020; GO:0042981; GO:0044822; GO:0048471; GO:0070062 0 0 0 PF04774;PF16174; Q9TT89 CHOYP_PTL.1.1 m.12143 sp HXB7_BOVIN 45 180 87 4 82 259 39 208 2.51E-39 139 HXB7_BOVIN reviewed Homeobox protein Hox-B7 HOXB7 Bos taurus (Bovine) 217 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007275; GO:0043565 0 0 0 PF00046; Q9UIF8 CHOYP_BRAFLDRAFT_122791.3.6 m.14084 sp BAZ2B_HUMAN 37.977 603 311 12 505 1047 663 1262 2.51E-104 377 BAZ2B_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00439;PF02791;PF01429;PF00628;PF15613; Q9VCA8 CHOYP_LOC100641396.26.27 m.64066 sp ANKHM_DROME 31.863 408 232 11 9 371 619 1025 2.51E-40 155 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VHP0 CHOYP_LOC100369346.1.1 m.31188 sp DDX3_DROME 55.357 56 19 2 15 64 1 56 2.51E-06 49.3 DDX3_DROME reviewed ATP-dependent RNA helicase bel (EC 3.6.4.13) (Protein belle) bel CG9748 Drosophila melanogaster (Fruit fly) 798 ecdysone-mediated induction of salivary gland cell autophagic cell death [GO:0035072]; instar larval development [GO:0002168]; mitotic sister chromatid segregation [GO:0000070]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468]; RNA interference [GO:0016246]; RNA secondary structure unwinding [GO:0010501]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; translational initiation [GO:0006413] GO:0000070; GO:0002168; GO:0003723; GO:0004004; GO:0005524; GO:0005737; GO:0005811; GO:0005829; GO:0005875; GO:0006413; GO:0007283; GO:0007286; GO:0010468; GO:0010501; GO:0016246; GO:0016442; GO:0035072; GO:0043025; GO:0043186; GO:0048477 0 0 0 PF00270;PF00271; Q9Y2C9 CHOYP_BRAFLDRAFT_89683.4.5 m.36721 sp TLR6_HUMAN 36.792 106 64 3 55 159 642 745 2.51E-08 60.1 TLR6_HUMAN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) 796 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0038124; GO:0042088; GO:0042496; GO:0042742; GO:0043123; GO:0043507; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; E9Q555 CHOYP_BRAFLDRAFT_108418.1.2 m.22801 sp RN213_MOUSE 23.77 366 232 15 227 569 984 1325 2.52E-12 73.9 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O15990 CHOYP_KARG.3.11 m.2495 sp KARG_LIOJA 64.655 116 41 0 1 116 167 282 2.52E-49 163 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O17320 CHOYP_ACA1_328780.1.1 m.64130 sp ACT_CRAGI 99.038 104 1 0 7 110 273 376 2.52E-71 219 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O75382 CHOYP_BRAFLDRAFT_87319.1.5 m.33127 sp TRIM3_HUMAN 27.35 117 79 2 35 146 579 694 2.52E-08 55.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_TRIM3.12.58 m.20545 sp TRIM3_HUMAN 28.226 124 84 3 152 272 623 744 2.52E-07 55.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75691 CHOYP_IM_7159098.1.1 m.1576 sp UTP20_HUMAN 32.862 283 184 4 3 284 184 461 2.52E-39 150 UTP20_HUMAN reviewed Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) 2785 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of cell proliferation [GO:0008285]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0008285; GO:0030686; GO:0030688; GO:0032040; GO:0044822 0 0 0 PF07539; P0CT40 CHOYP_LOC100494190.1.1 m.51116 sp TF29_SCHPO 26.881 904 565 26 419 1256 369 1242 2.52E-79 290 TF29_SCHPO reviewed Transposon Tf2-9 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-9 SPBC9B6.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0005737; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; Q05120 CHOYP_contig_043069 m.49719 sp UBIL_NPVOP 35.385 65 37 1 47 111 18 77 2.52E-06 45.4 UBIL_NPVOP reviewed Ubiquitin-like protein V-UBI ORF25 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) 93 modulation by virus of host protein ubiquitination [GO:0039648] GO:0039648 0 0 0 PF00240; Q149M9 CHOYP_LOC100378314.2.3 m.29347 sp NWD1_HUMAN 33.598 378 224 10 1 358 538 908 2.52E-55 198 NWD1_HUMAN reviewed NACHT domain- and WD repeat-containing protein 1 NWD1 Homo sapiens (Human) 1564 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; Q3KQ80 CHOYP_LOC100178916.1.1 m.26391 sp STPG1_XENLA 44.586 314 170 4 47 359 40 350 2.52E-81 254 STPG1_XENLA reviewed O(6)-methylguanine-induced apoptosis 2 (MAPO2) (Sperm-tail PG-rich repeat-containing protein 1) stpg1 Xenopus laevis (African clawed frog) 352 apoptotic process [GO:0006915] GO:0005634; GO:0005737; GO:0006915 0 0 0 PF07004; Q460N3 CHOYP_PAR15.4.6 m.57975 sp PAR15_HUMAN 41.892 148 81 4 224 368 478 623 2.52E-24 107 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_LOC100906063.2.3 m.55616 sp SVEP1_HUMAN 30.337 178 108 3 152 329 945 1106 2.52E-16 86.7 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q58EG3 CHOYP_PVRL1.2.3 m.3934 sp NECT3_DANRE 24.419 344 208 20 2 331 21 326 2.52E-09 63.2 NECT3_DANRE reviewed Nectin-3-like protein (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3-like) nectin3 pvrl3l si:dkey-62a13.5 zgc:113035 Danio rerio (Zebrafish) (Brachydanio rerio) 574 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0042803; GO:0050839 0 0 0 PF08205;PF07686; Q5PQ50 CHOYP_NUDT19.1.1 m.12866 sp NUD19_XENLA 38.4 375 192 10 36 397 1 349 2.52E-81 258 NUD19_XENLA reviewed Nucleoside diphosphate-linked moiety X motif 19 (Nudix motif 19) (EC 3.6.1.-) nudt19 Xenopus laevis (African clawed frog) 380 0 GO:0005777; GO:0016787; GO:0046872 0 0 0 0 Q5XK91 CHOYP_BRAFLDRAFT_125263.8.9 m.58995 sp FBCDB_XENLA 31.818 352 193 10 21 333 110 453 2.52E-51 179 FBCDB_XENLA reviewed Fibrinogen C domain-containing protein 1-B fibcd1-b Xenopus laevis (African clawed frog) 457 0 GO:0008061; GO:0016021; GO:0046872 0 0 0 PF00147; Q5ZJP7 CHOYP_BRAFLDRAFT_67583.1.1 m.9465 sp KCTD7_CHICK 33.193 238 143 5 27 250 45 280 2.52E-37 137 KCTD7_CHICK reviewed BTB/POZ domain-containing protein KCTD7 KCTD7 RCJMB04_16j10 Gallus gallus (Chicken) 289 protein homooligomerization [GO:0051260] GO:0005829; GO:0005886; GO:0051260 0 0 0 PF02214; Q62283 CHOYP_BRAFLDRAFT_265104.1.1 m.4645 sp TSN7_MOUSE 40.316 253 140 4 19 265 2 249 2.52E-64 204 TSN7_MOUSE reviewed Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (PE31) (TALLA homolog) (Transmembrane 4 superfamily member 2) (CD antigen CD231) Tspan7 Mxs1 Tm4sf2 Mus musculus (Mouse) 249 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q6Y1S1 CHOYP_BRAFLDRAFT_68270.4.6 m.34076 sp MYD88_RAT 24.155 207 137 9 559 753 98 296 2.52E-06 53.5 MYD88_RAT reviewed Myeloid differentiation primary response protein MyD88 Myd88 Rattus norvegicus (Rat) 296 cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; establishment of endothelial intestinal barrier [GO:0090557]; immunoglobulin mediated immune response [GO:0016064]; induced systemic resistance [GO:0009682]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000338]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil migration [GO:1902622]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063]; type I interferon biosynthetic process [GO:0045351] GO:0002238; GO:0002755; GO:0005102; GO:0005121; GO:0005149; GO:0005829; GO:0005886; GO:0006954; GO:0007254; GO:0008063; GO:0009615; GO:0009682; GO:0014069; GO:0016064; GO:0019221; GO:0031663; GO:0032494; GO:0032740; GO:0032747; GO:0032755; GO:0032760; GO:0043066; GO:0043123; GO:0043234; GO:0044130; GO:0045080; GO:0045351; GO:0046330; GO:0048661; GO:0050671; GO:0050727; GO:0050830; GO:0051092; GO:0090557; GO:1902622; GO:2000338; GO:2000341 0 0 0 PF00531;PF01582; Q7ZWA3 CHOYP_BIVM.3.3 m.63238 sp RBMX_DANRE 40.856 257 101 9 4 244 2 223 2.52E-29 121 RBMX_DANRE reviewed "RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G)" rbmx Danio rerio (Zebrafish) (Brachydanio rerio) 379 "cellular response to interleukin-1 [GO:0071347]; membrane protein ectodomain proteolysis [GO:0006509]; mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000166; GO:0000381; GO:0001047; GO:0003682; GO:0003723; GO:0003729; GO:0005634; GO:0005719; GO:0006366; GO:0006397; GO:0006509; GO:0007275; GO:0008380; GO:0044530; GO:0045944; GO:0048025; GO:0048026; GO:0051260; GO:0070062; GO:0071013; GO:0071347 0 0 0 PF08081;PF00076; Q90YS3 CHOYP_BRAFLDRAFT_275374.3.3 m.55251 sp RS2_ICTPU 79.412 102 18 1 5 103 173 274 2.52E-51 165 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q96RW7 CHOYP_DSIM_GD20989.1.1 m.15661 sp HMCN1_HUMAN 30.435 138 75 4 60 193 2396 2516 2.52E-09 61.2 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9ESN6 CHOYP_LOC100376883.1.1 m.53360 sp TRIM2_MOUSE 23.629 237 156 9 251 475 484 707 2.52E-09 63.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9P2R3 CHOYP_LOC100372945.1.2 m.36022 sp ANFY1_HUMAN 48.993 149 74 2 2 149 1 148 2.52E-42 152 ANFY1_HUMAN reviewed Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif) ANKFY1 ANKHZN KIAA1255 Homo sapiens (Human) 1169 "endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; endosome localization [GO:0032439]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005765; GO:0005769; GO:0005829; GO:0006897; GO:0010008; GO:0016020; GO:0017137; GO:0032439; GO:0034058; GO:0042147; GO:0044354; GO:0046872; GO:0048549; GO:0070062; GO:0090160; GO:1901981 0 0 0 PF00023;PF12796;PF00651;PF01363; Q9Z2E3 CHOYP_PHUM_PHUM319520.1.1 m.49853 sp ERN2_MOUSE 28.729 362 213 19 1523 1860 559 899 2.52E-24 115 ERN2_MOUSE reviewed Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (Ire1-beta) (IRE1b) (mIre1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] Ern2 Ire2 Mus musculus (Mouse) 911 "activation of JUN kinase activity [GO:0007257]; activation of signaling protein activity involved in unfolded protein response [GO:0006987]; apoptotic chromosome condensation [GO:0030263]; cell cycle arrest [GO:0007050]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mRNA processing [GO:0006397]; negative regulation of transcription, DNA-templated [GO:0045892]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; response to endoplasmic reticulum stress [GO:0034976]; rRNA catabolic process [GO:0016075]; transcription, DNA-templated [GO:0006351]" GO:0000287; GO:0004519; GO:0004540; GO:0004674; GO:0005524; GO:0006351; GO:0006355; GO:0006397; GO:0006468; GO:0006987; GO:0007050; GO:0007257; GO:0016021; GO:0016075; GO:0030263; GO:0034976; GO:0045892; GO:0070059; GO:1990604 0 0 0 PF00069;PF06479; A2ASS6 CHOYP_PHUM_PHUM226120.5.7 m.43552 sp TITIN_MOUSE 24.561 1767 1047 45 582 2309 7150 8669 2.53E-111 404 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A4IF63 CHOYP_BRAFLDRAFT_88223.7.22 m.33030 sp TRIM2_BOVIN 26.337 243 162 10 303 533 484 721 2.53E-09 63.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_ARF6.1.2 m.3975 sp CRNS1_HUMAN 49.153 118 55 3 1 117 644 757 2.53E-26 107 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 B2RU80 CHOYP_PTPRQ.4.8 m.23171 sp PTPRB_MOUSE 24.633 613 395 27 9 595 1232 1803 2.53E-26 118 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; E7FAM5 CHOYP_NEMVEDRAFT_V1G212280.3.3 m.30224 sp LIN41_DANRE 24.936 389 231 12 21 359 59 436 2.53E-23 109 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O02776 CHOYP_PARG.1.1 m.24813 sp PARG_BOVIN 43.91 624 305 13 40 638 333 936 2.53E-157 483 PARG_BOVIN reviewed Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) PARG Bos taurus (Bovine) 977 ATP generation from poly-ADP-D-ribose [GO:1990966]; carbohydrate metabolic process [GO:0005975] GO:0004649; GO:0005634; GO:0005975; GO:1990966 0 0 0 PF05028; O54890 CHOYP_PAT3.3.4 m.52627 sp ITB3_MOUSE 34.095 613 364 17 8 606 196 782 2.53E-110 356 ITB3_MOUSE reviewed Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) Itgb3 Mus musculus (Mouse) 787 activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cell adhesion mediated by integrin [GO:0033627]; cell growth [GO:0016049]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell projection morphogenesis [GO:0048858]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045715]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of extracellular matrix organization [GO:1903053]; regulation of protein tyrosine kinase activity [GO:0061097]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; viral entry into host cell [GO:0046718] GO:0001938; GO:0001954; GO:0001968; GO:0002020; GO:0003756; GO:0004872; GO:0005178; GO:0005634; GO:0005886; GO:0005925; GO:0007044; GO:0007160; GO:0007229; GO:0008305; GO:0009897; GO:0009986; GO:0010595; GO:0010628; GO:0010745; GO:0010763; GO:0010888; GO:0014909; GO:0016049; GO:0016324; GO:0016477; GO:0019899; GO:0030168; GO:0030334; GO:0030335; GO:0031258; GO:0031527; GO:0031528; GO:0031589; GO:0032147; GO:0032369; GO:0032587; GO:0032956; GO:0033627; GO:0033690; GO:0034113; GO:0034446; GO:0034679; GO:0034683; GO:0035867; GO:0036120; GO:0038027; GO:0042470; GO:0042802; GO:0043184; GO:0043235; GO:0045672; GO:0045715; GO:0045780; GO:0046718; GO:0048008; GO:0048146; GO:0048858; GO:0050731; GO:0050748; GO:0050839; GO:0050840; GO:0050919; GO:0060055; GO:0061097; GO:0070062; GO:0070527; GO:0071133; GO:1900026; GO:1903053; GO:2000406 0 0 0 PF07974;PF08725;PF07965;PF00362; O73853 CHOYP_LOC100371043.3.5 m.24648 sp CP17A_ICTPU 34.728 478 296 8 31 499 31 501 2.53E-88 283 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; P08548 CHOYP_LIN1.1.3 m.7595 sp LIN1_NYCCO 29.228 479 311 12 98 565 385 846 2.53E-40 164 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P16157 CHOYP_LOC754035.2.6 m.36582 sp ANK1_HUMAN 32.696 575 363 4 168 720 90 662 2.53E-86 301 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17560 CHOYP_BRAFLDRAFT_87662.1.1 m.5474 sp RENBP_PIG 51.654 393 187 2 41 430 8 400 2.53E-151 437 RENBP_PIG reviewed N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP) RENBP Sus scrofa (Pig) 402 N-acetylglucosamine metabolic process [GO:0006044]; N-acetylneuraminate catabolic process [GO:0019262] GO:0004866; GO:0006044; GO:0019262; GO:0050121 PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. 0 0 0 P27600 CHOYP_LOC100371005.1.2 m.2527 sp GNA12_MOUSE 65.294 340 116 1 29 366 40 379 2.53E-163 464 GNA12_MOUSE reviewed Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) Gna12 Gna-12 Mus musculus (Mouse) 379 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell differentiation [GO:0030154]; embryonic digit morphogenesis [GO:0042733]; G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]; response to drug [GO:0042493]; Rho protein signal transduction [GO:0007266] GO:0001701; GO:0003924; GO:0004871; GO:0005525; GO:0005834; GO:0005925; GO:0007186; GO:0007188; GO:0007266; GO:0008360; GO:0010762; GO:0030154; GO:0031526; GO:0031683; GO:0031752; GO:0032006; GO:0032434; GO:0035556; GO:0042493; GO:0042733; GO:0046872 0 0 0 PF00503; P35475 CHOYP_IDUA.3.3 m.40389 sp IDUA_HUMAN 55.655 336 142 3 1 336 118 446 2.53E-123 371 IDUA_HUMAN reviewed Alpha-L-iduronidase (EC 3.2.1.76) IDUA Homo sapiens (Human) 653 chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate catabolic process [GO:0030209]; disaccharide metabolic process [GO:0005984]; glycosaminoglycan catabolic process [GO:0006027] GO:0003940; GO:0005984; GO:0006027; GO:0030135; GO:0030207; GO:0030209; GO:0043202; GO:0070062 0 0 0 PF01229; P35951 CHOYP_BRAFLDRAFT_125735.3.3 m.60824 sp LDLR_MOUSE 59.677 62 24 1 55 115 80 141 2.53E-17 79.7 LDLR_MOUSE reviewed Low-density lipoprotein receptor (LDL receptor) Ldlr Mus musculus (Mouse) 862 cellular response to fatty acid [GO:0071398]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; lipoprotein metabolic process [GO:0042157]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of gene expression [GO:0010629]; phospholipid transport [GO:0015914]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001948; GO:0002020; GO:0005041; GO:0005509; GO:0005764; GO:0005768; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005905; GO:0006629; GO:0008203; GO:0009897; GO:0009986; GO:0010628; GO:0010629; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016021; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0034362; GO:0034383; GO:0042157; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0050729; GO:0070508; GO:0071398; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P46023 CHOYP_LOC584366.1.1 m.23594 sp GR101_LYMST 35.98 403 249 5 1 399 644 1041 2.53E-77 263 GR101_LYMST reviewed G-protein coupled receptor GRL101 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 1115 0 GO:0005886; GO:0016021; GO:0016500 0 0 0 PF00001;PF00057;PF12799;PF13855; P55214 CHOYP_LOC100068258.1.1 m.37406 sp CASP7_MESAU 44.981 269 135 6 11 275 17 276 2.53E-70 228 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 P57103 CHOYP_BRAFLDRAFT_78683.3.4 m.48597 sp NAC3_HUMAN 33.333 957 465 27 20 887 49 921 2.53E-140 443 NAC3_HUMAN reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) SLC8A3 NCX3 Homo sapiens (Human) 927 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; ion transport [GO:0006811]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005886; GO:0005887; GO:0006811; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0016528; GO:0021537; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1903779; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; P70610 CHOYP_LOC100549486.1.1 m.54965 sp DOC2B_RAT 62.385 327 109 2 325 637 79 405 2.53E-139 415 DOC2B_RAT reviewed Double C2-like domain-containing protein beta (Doc2-beta) Doc2b Rattus norvegicus (Rat) 412 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; exocytosis [GO:0006887]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of insulin secretion [GO:0032024]; positive regulation of vesicle fusion [GO:0031340]; protein localization [GO:0008104] GO:0005509; GO:0005544; GO:0005737; GO:0005886; GO:0006887; GO:0008104; GO:0019905; GO:0030276; GO:0031340; GO:0032024; GO:0045956; GO:0048791; GO:0098793 0 0 0 PF00168; P82198 CHOYP_ANT_25430.1.2 m.612 sp BGH3_MOUSE 26.04 553 333 23 219 750 138 635 2.53E-22 107 BGH3_MOUSE reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) Tgfbi Mus musculus (Mouse) 683 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198] GO:0001525; GO:0002062; GO:0005518; GO:0005578; GO:0005604; GO:0005615; GO:0005802; GO:0007155; GO:0008283; GO:0030198; GO:0050839; GO:0050840; GO:0070062 0 0 0 PF02469; Q13263 CHOYP_LOC100636374.4.4 m.62898 sp TIF1B_HUMAN 25.767 163 106 5 10 157 153 315 2.53E-09 58.2 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q24K15 CHOYP_ANGP2.5.5 m.59867 sp ANGP4_BOVIN 41.475 217 120 4 79 291 283 496 2.53E-55 189 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q29L43 CHOYP_LOC100878853.1.1 m.37993 sp MON2_DROPS 54.575 306 129 4 2 303 475 774 2.53E-98 322 MON2_DROPS reviewed Protein MON2 homolog mon2 GA16450 Drosophila pseudoobscura pseudoobscura (Fruit fly) 1701 protein transport [GO:0015031] GO:0015031 0 0 0 PF16213;PF09324;PF16206;PF12783; Q60648 CHOYP_LOC100547490.1.1 m.5822 sp SAP3_MOUSE 25.843 178 114 6 43 217 28 190 2.53E-10 61.2 SAP3_MOUSE reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) 193 ganglioside catabolic process [GO:0006689]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; neurological system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; positive regulation of hydrolase activity [GO:0051345] GO:0004563; GO:0005319; GO:0005739; GO:0005764; GO:0005889; GO:0006689; GO:0007611; GO:0008047; GO:0009313; GO:0009898; GO:0016004; GO:0019915; GO:0032428; GO:0045179; GO:0050877; GO:0050885; GO:0051345; GO:0070062 0 0 0 PF02221; Q68EV6 CHOYP_LOC101071891.2.2 m.49758 sp RM28_XENLA 47.032 219 107 4 41 257 24 235 2.53E-57 190 RM28_XENLA reviewed "39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28)" mrpl28 Xenopus laevis (African clawed frog) 253 0 GO:0003735; GO:0005739; GO:0005840 0 0 0 PF00830; Q6Q899 CHOYP_IFIH1.9.14 m.54678 sp DDX58_MOUSE 34.746 708 415 19 511 1196 242 924 2.53E-108 365 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6UXB8 CHOYP_GLIPR1.1.3 m.6569 sp PI16_HUMAN 34.706 170 92 7 49 207 36 197 2.53E-20 97.8 PI16_HUMAN reviewed Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 Homo sapiens (Human) 463 0 GO:0016021; GO:0030414; GO:0070062 0 0 0 PF00188; Q7Z3K6 CHOYP_PHUM_PHUM361660.1.1 m.63423 sp MIER3_HUMAN 46.991 349 163 11 1 340 28 363 2.53E-87 281 MIER3_HUMAN reviewed Mesoderm induction early response protein 3 (Mi-er3) MIER3 Homo sapiens (Human) 550 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01448;PF00249; Q7ZYG4 CHOYP_LOC100366488.1.1 m.56518 sp OSTF1_XENLA 55.172 203 86 2 18 215 12 214 2.53E-79 239 OSTF1_XENLA reviewed Osteoclast-stimulating factor 1 ostf1 Xenopus laevis (African clawed frog) 214 0 GO:0005737 0 0 0 PF12796;PF00018; Q80VI1 CHOYP_LOC100567036.2.2 m.36206 sp TRI56_MOUSE 21.935 310 196 10 35 326 17 298 2.53E-16 85.9 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q811D2 CHOYP_LOC100371645.2.2 m.50650 sp ANR26_MOUSE 25.894 699 425 14 488 1170 648 1269 2.53E-39 164 ANR26_MOUSE reviewed Ankyrin repeat domain-containing protein 26 Ankrd26 Kiaa1074 Mus musculus (Mouse) 1581 glucose homeostasis [GO:0042593]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of multicellular organism growth [GO:0040015]; negative regulation of organ growth [GO:0046621]; regulation of fatty acid metabolic process [GO:0019217]; regulation of feeding behavior [GO:0060259]; regulation of lipid metabolic process [GO:0019216] GO:0005813; GO:0019216; GO:0019217; GO:0040015; GO:0042593; GO:0045599; GO:0046621; GO:0046627; GO:0060259; GO:0070373 0 0 0 PF12796;PF12001; Q8K0U4 CHOYP_BRAFLDRAFT_57788.7.10 m.47618 sp HS12A_MOUSE 34.839 310 150 8 8 271 49 352 2.53E-49 175 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8R000 CHOYP_OSTA.1.1 m.11011 sp OSTA_MOUSE 29.893 281 191 3 31 311 48 322 2.53E-26 109 OSTA_MOUSE reviewed Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha) Slc51a Osta Mus musculus (Mouse) 340 bile acid and bile salt transport [GO:0015721]; transport [GO:0006810] GO:0005215; GO:0005789; GO:0005886; GO:0006810; GO:0015721; GO:0016021; GO:0042803; GO:0043234; GO:0046982 0 0 0 PF03619; Q8TCT0 CHOYP_CERK.2.2 m.62896 sp CERK1_HUMAN 34.199 231 148 3 54 280 81 311 2.53E-39 152 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q9CQY2 CHOYP_RAM.1.1 m.61317 sp RAM_MOUSE 37.079 89 47 1 41 120 4 92 2.53E-08 53.9 RAM_MOUSE reviewed RNMT-activating mini protein (RAM) (Protein FAM103A1) Fam103a1 Mus musculus (Mouse) 119 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031] GO:0003723; GO:0005634; GO:0005845; GO:0006370; GO:0032259; GO:0036031; GO:0044822 0 0 0 PF15320; Q9CR98 CHOYP_LOC100118377.1.1 m.62623 sp F136A_MOUSE 29.412 119 76 2 1 113 16 132 2.53E-15 70.1 F136A_MOUSE reviewed Protein FAM136A Fam136a Mus musculus (Mouse) 138 0 GO:0005737; GO:0005739 0 0 0 PF05811; Q9I8C7 CHOYP_ACHA9.2.3 m.36703 sp ACH10_CHICK 35.125 279 174 5 1 276 165 439 2.53E-53 182 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9P215 CHOYP_LOC101169293.4.4 m.19717 sp POGK_HUMAN 38.76 129 75 3 258 383 197 324 2.53E-18 91.3 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9QZR8 CHOYP_BRAFLDRAFT_125231.1.1 m.52559 sp PDZD2_RAT 33.445 299 145 9 623 913 542 794 2.53E-28 127 PDZD2_RAT reviewed PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Plakophilin-related armadillo repeat protein-interacting PDZ protein) [Cleaved into: Processed PDZ domain-containing protein 2] Pdzd2 Papin Pdzk3 Pin1 Rattus norvegicus (Rat) 2766 cell adhesion [GO:0007155]; intracellular signal transduction [GO:0035556] GO:0005576; GO:0005634; GO:0005737; GO:0005783; GO:0005911; GO:0007155; GO:0014069; GO:0035556; GO:0043005; GO:0045177 0 0 0 PF00595; Q9UPS8 CHOYP_ANKRD7.1.3 m.11623 sp ANR26_HUMAN 27.835 1067 630 23 1306 2305 716 1709 2.53E-69 263 ANR26_HUMAN reviewed Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) 1709 0 GO:0005813 0 0 0 PF00023;PF12796;PF12001; Q9Y2Q0 CHOYP_TSP_05176.1.1 m.16510 sp AT8A1_HUMAN 52.874 174 78 2 1 173 947 1117 2.53E-54 191 AT8A1_HUMAN reviewed Phospholipid-transporting ATPase IA (EC 3.6.3.1) (ATPase class I type 8A member 1) (Chromaffin granule ATPase II) (P4-ATPase flippase complex alpha subunit ATP8A1) ATP8A1 ATPIA Homo sapiens (Human) 1164 Golgi vesicle budding [GO:0048194]; ion transmembrane transport [GO:0034220]; learning [GO:0007612]; phospholipid translocation [GO:0045332]; positive regulation of cell migration [GO:0030335]; positive regulation of phospholipid translocation [GO:0061092] GO:0000139; GO:0000287; GO:0004012; GO:0005524; GO:0005783; GO:0005794; GO:0005802; GO:0005886; GO:0007612; GO:0016020; GO:0016021; GO:0019829; GO:0030335; GO:0034220; GO:0042584; GO:0043231; GO:0045332; GO:0048194; GO:0061092; GO:0070062 0 0 0 PF00122;PF16212;PF16209; B3EWY9 CHOYP_LOC100182237.1.2 m.5177 sp MLP_ACRMI 27.82 1064 623 35 200 1204 388 1365 2.54E-98 354 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B8I6E7 CHOYP_OSA.2.2 m.42665 sp IF2_CLOCE 38.406 138 85 0 34 171 307 444 2.54E-14 81.6 IF2_CLOCE reviewed Translation initiation factor IF-2 infB Ccel_0457 Clostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) 1161 0 GO:0003743; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF11987;PF04760; D3YXG0 CHOYP_LOC100880815.5.7 m.54594 sp HMCN1_MOUSE 25.866 491 299 20 61 519 3876 4333 2.54E-25 117 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E1BJS7 CHOYP_BRAFLDRAFT_88223.8.22 m.33067 sp LIN41_BOVIN 21.488 484 318 19 66 516 278 732 2.54E-07 57.4 LIN41_BOVIN reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Bos taurus (Bovine) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; H3BS89 CHOYP_LOC100118354.2.4 m.44636 sp T178B_HUMAN 20.652 276 152 5 20 235 4 272 2.54E-07 54.7 T178B_HUMAN reviewed Transmembrane protein 178B TMEM178B Homo sapiens (Human) 294 0 GO:0016021 0 0 0 PF13903; O13395 CHOYP_LOC100641628.3.3 m.60557 sp CHS6_USTMA 31.835 267 140 10 197 431 526 782 2.54E-22 106 CHS6_USTMA reviewed Chitin synthase 6 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 6) (Class-V chitin synthase 6) CHS6 UMAG_10367 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 1180 cell wall organization [GO:0071555] GO:0003677; GO:0004100; GO:0005886; GO:0016021; GO:0030659; GO:0071555 0 0 0 PF00173;PF08766; P08021 CHOYP_FMRF.4.4 m.62077 sp FMRF_APLCA 33.667 300 141 20 126 408 243 501 2.54E-08 59.7 FMRF_APLCA reviewed FMRF-amide neuropeptides [Cleaved into: FLRF-amide; FMRF-amide] 0 Aplysia californica (California sea hare) 597 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF01581; P08478 CHOYP_AMDA.1.1 m.27066 sp AMDA_XENLA 49.206 315 140 10 63 369 400 702 2.54E-87 286 AMDA_XENLA reviewed Peptidyl-glycine alpha-amidating monooxygenase A (PAM-A) (Peptide C-terminal alpha-amidating enzyme I) (AE-I) (Peptidyl-glycine alpha-amidating monooxygenase I) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase A (PHM-A) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase A (EC 4.3.2.5) (Peptidylamidoglycolate lyase-A) (PAL-A)] pam-a Xenopus laevis (African clawed frog) 935 peptide metabolic process [GO:0006518] GO:0004504; GO:0004598; GO:0005507; GO:0006518; GO:0016021; GO:0030658 0 0 0 PF03712;PF01082;PF01436; P16912 CHOYP_LOC661839.1.1 m.61042 sp KDC2_DROME 64.968 314 110 0 30 343 270 583 2.54E-158 458 KDC2_DROME reviewed Protein kinase DC2 (EC 2.7.11.1) Pka-C3 DC2 CG6117 Drosophila melanogaster (Fruit fly) 583 imaginal disc-derived wing morphogenesis [GO:0007476]; protein phosphorylation [GO:0006468] GO:0004674; GO:0004691; GO:0005524; GO:0005952; GO:0006468; GO:0007476 0 0 0 PF00069; P29030 CHOYP_COCA1.3.6 m.49360 sp CHIT_BRUMA 48.98 49 25 0 327 375 451 499 2.54E-09 62.4 CHIT_BRUMA reviewed Endochitinase (EC 3.2.1.14) (MF1 antigen) 0 Brugia malayi (Filarial nematode worm) 504 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0006032; GO:0008061 0 0 0 PF01607;PF00704; P39021 CHOYP_LOC556898.1.1 m.6234 sp MEOX2_XENLA 57.143 133 47 2 104 232 115 241 2.54E-38 139 MEOX2_XENLA reviewed Homeobox protein MOX-2 meox2 mox2 Xenopus laevis (African clawed frog) 298 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007275; GO:0016607; GO:0043565 0 0 0 PF00046; P79960 CHOYP_NPY6R.1.1 m.25680 sp APJA_XENLA 27.362 307 185 10 20 306 36 324 2.54E-09 61.2 APJA_XENLA reviewed Apelin receptor A (Angiotensin receptor-like 1a) (xAngio1) (Angiotensin receptor-related protein A) (G-protein coupled receptor APJ-A) (APJa) (Mesenchyme-associated serpentine receptor) (x-MSR) aplnr-a agtrl1 agtrl1-a agtrl1a angio1 msr Xenopus laevis (African clawed frog) 362 angiogenesis [GO:0001525]; apelin receptor signaling pathway [GO:0060183]; blood vessel development [GO:0001568]; cell differentiation [GO:0030154]; gastrulation [GO:0007369]; heart development [GO:0007507]; patterning of blood vessels [GO:0001569] GO:0001525; GO:0001568; GO:0001569; GO:0004945; GO:0005737; GO:0005886; GO:0007369; GO:0007507; GO:0016021; GO:0030154; GO:0060182; GO:0060183 0 0 0 PF00001; P86734 CHOYP_LOC100370897.1.5 m.5333 sp EPDR1_HALAI 28.218 202 121 11 30 210 1 199 2.54E-06 50.1 EPDR1_HALAI reviewed Ependymin-related protein 1 Sometsuke Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) 200 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00811; P98187 CHOYP_BRAFLDRAFT_61250.6.14 m.39604 sp CP4F8_HUMAN 38.144 485 272 9 19 485 20 494 2.54E-117 357 CP4F8_HUMAN reviewed Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016021; GO:0018685; GO:0019825; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q06348 CHOYP_LOC100547648.1.1 m.1248 sp PRRX2_MOUSE 48.583 247 76 10 32 266 30 237 2.54E-47 161 PRRX2_MOUSE reviewed Paired mesoderm homeobox protein 2 (PRX-2) (Homeobox protein S8) Prrx2 Prx2 S8 Mus musculus (Mouse) 247 "artery morphogenesis [GO:0048844]; cartilage development [GO:0051216]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system morphogenesis [GO:0048704]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of transcription, DNA-templated [GO:0006355]" GO:0002053; GO:0005634; GO:0006355; GO:0030326; GO:0042472; GO:0042474; GO:0043565; GO:0045880; GO:0048701; GO:0048704; GO:0048844; GO:0051216; GO:0071837 0 0 0 PF00046;PF03826; Q08347 CHOYP_DALK_0128.1.1 m.49633 sp BDS1_YEAST 26.592 534 376 9 60 583 102 629 2.54E-58 209 BDS1_YEAST reviewed Alkyl/aryl-sulfatase BDS1 (EC 3.1.6.-) (Bacterially-derived sulfatase 1) BDS1 YOL164W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 646 dodecyl sulfate metabolic process [GO:0018909] GO:0004065; GO:0018741; GO:0018909; GO:0046872 0 0 0 PF14864;PF14863;PF00753; Q08347 CHOYP_LOC100207466.1.1 m.4973 sp BDS1_YEAST 28.651 541 358 13 58 580 100 630 2.54E-66 231 BDS1_YEAST reviewed Alkyl/aryl-sulfatase BDS1 (EC 3.1.6.-) (Bacterially-derived sulfatase 1) BDS1 YOL164W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 646 dodecyl sulfate metabolic process [GO:0018909] GO:0004065; GO:0018741; GO:0018909; GO:0046872 0 0 0 PF14864;PF14863;PF00753; Q13231 CHOYP_CHIT3.1.1 m.16286 sp CHIT1_HUMAN 46.362 481 212 10 182 654 23 465 2.54E-143 432 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q2VLG6 CHOYP_LOC762897.1.3 m.30337 sp C163A_CANLF 40.991 222 112 6 249 465 157 364 2.54E-38 152 C163A_CANLF reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis lupus familiaris (Dog) (Canis familiaris) 1133 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q3ZAV0 CHOYP_CCDC60.1.1 m.49941 sp CCD60_RAT 26.034 580 315 23 146 707 44 527 2.54E-34 141 CCD60_RAT reviewed Coiled-coil domain-containing protein 60 Ccdc60 Rattus norvegicus (Rat) 542 0 0 0 0 0 PF15769; Q40588 CHOYP_LOC100198324.3.6 m.57752 sp ASO_TOBAC 26.61 590 320 22 92 652 45 550 2.54E-46 176 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q460N5 CHOYP_LOC100367414.1.7 m.21233 sp PAR14_HUMAN 26.544 1895 1247 48 593 2455 19 1800 2.54E-170 577 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q497B2 CHOYP_TMEM45A.1.1 m.10963 sp TM45B_RAT 37.662 231 125 6 1 218 1 225 2.54E-40 144 TM45B_RAT reviewed Transmembrane protein 45B Tmem45b Rattus norvegicus (Rat) 278 0 GO:0016021 0 0 0 PF04819; Q4U4S6 CHOYP_LOC101345275.1.1 m.1797 sp XIRP2_MOUSE 71.875 32 9 0 136 167 3301 3332 2.54E-09 59.3 XIRP2_MOUSE reviewed Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Myogenic MEF2-activated Xin-related protein) (Myomaxin) (mXinbeta) Xirp2 Cmya3 Xin2 Mus musculus (Mouse) 3784 actin cytoskeleton organization [GO:0030036]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; ventricular septum development [GO:0003281] GO:0003281; GO:0008270; GO:0030018; GO:0030036; GO:0030054; GO:0045216; GO:0051393; GO:0055008 0 0 0 PF00412;PF08043; Q53GL7 CHOYP_LOC100368410.2.2 m.44510 sp PAR10_HUMAN 35.714 70 43 1 311 380 1 68 2.54E-07 56.6 PAR10_HUMAN reviewed Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 Homo sapiens (Human) 1025 "negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein import into nucleus, translocation [GO:0033159]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; negative regulation of viral genome replication [GO:0045071]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; regulation of chromatin assembly [GO:0010847]" GO:0003950; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0006471; GO:0010629; GO:0010847; GO:0032088; GO:0033159; GO:0045071; GO:0048147; GO:0070212; GO:0070213; GO:0070530; GO:1900045 0 0 0 PF00644; Q5BJ65 CHOYP_H2AV.1.7 m.12182 sp H2AV_XENTR 97.656 128 3 0 1 128 1 128 2.54E-84 245 H2AV_XENTR reviewed Histone H2A.V (H2A.F/Z) h2afv TGas096d24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 chromatin silencing [GO:0006342] GO:0000786; GO:0000790; GO:0003677; GO:0006342 0 0 0 PF00125;PF16211; Q5M823 CHOYP_TAD2A.1.1 m.27478 sp NUDC2_RAT 54.605 152 69 0 2 153 3 154 2.54E-59 184 NUDC2_RAT reviewed NudC domain-containing protein 2 Nudcd2 Rattus norvegicus (Rat) 157 0 GO:0000777; GO:0000922; GO:0005737; GO:0005815; GO:0070062 0 0 0 PF04969; Q62805 CHOYP_LOC567820.1.1 m.51203 sp GALR1_RAT 22.802 364 226 13 2 340 13 346 2.54E-07 55.8 GALR1_RAT reviewed Galanin receptor type 1 (GAL1-R) (GALR-1) Galr1 Galnr Galnr1 Rattus norvegicus (Rat) 346 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of adenylate cyclase activity [GO:0007194]; positive regulation of cortisol secretion [GO:0051464]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0004966; GO:0005886; GO:0005887; GO:0007186; GO:0007189; GO:0007194; GO:0007204; GO:0016021; GO:0017046; GO:0042923; GO:0045944; GO:0051464 0 0 0 PF00001; Q6PFY8 CHOYP_LOC100369333.10.32 m.32522 sp TRI45_MOUSE 29.412 204 124 5 5 196 127 322 2.54E-12 72.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6Q899 CHOYP_LOC100378083.2.3 m.31711 sp DDX58_MOUSE 29.619 709 428 22 877 1552 223 893 2.54E-56 216 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q8N6D5 CHOYP_AN8019.2.1.1 m.27468 sp ANR29_HUMAN 39.2 125 75 1 3 126 57 181 2.54E-22 92 ANR29_HUMAN reviewed Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) 301 0 0 0 0 0 PF00023;PF12796; Q8NFU7 CHOYP_LOC100184254.1.1 m.11787 sp TET1_HUMAN 46.032 63 32 1 64 126 586 646 2.54E-08 61.2 TET1_HUMAN reviewed Methylcytosine dioxygenase TET1 (EC 1.14.11.n2) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) TET1 CXXC6 KIAA1676 LCX Homo sapiens (Human) 2136 "covalent chromatin modification [GO:0016569]; DNA demethylation [GO:0080111]; inner cell mass cell differentiation [GO:0001826]; negative regulation of methylation-dependent chromatin silencing [GO:0090310]; positive regulation of cell proliferation [GO:0008284]; positive regulation of histone methylation [GO:0031062]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein O-linked glycosylation [GO:0006493]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]" GO:0001826; GO:0005506; GO:0005634; GO:0006351; GO:0006493; GO:0008270; GO:0008284; GO:0016569; GO:0019827; GO:0031062; GO:0043566; GO:0045944; GO:0070579; GO:0080111; GO:0090310 0 0 0 PF12851;PF02008; Q8R143 CHOYP_PTTG1IP.1.1.1 m.57613 sp PTTG_MOUSE 53.333 135 60 2 62 195 42 174 2.54E-32 117 PTTG_MOUSE reviewed Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor) Pttg1ip Mus musculus (Mouse) 174 "negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]" GO:0002039; GO:0005634; GO:0005737; GO:0005886; GO:0006606; GO:0016020; GO:0016021; GO:0031398; GO:0043518; GO:0070062; GO:1902254; GO:1903364 0 0 0 0 Q8WPJ2 CHOYP_MANA.3.3 m.29185 sp MANA_MYTED 49.457 368 175 4 28 394 2 359 2.54E-130 382 MANA_MYTED reviewed "Mannan endo-1,4-beta-mannosidase (EC 3.2.1.78) (Beta-mannanase) (Endo-beta-1,4-mannanase) (Man5A) (ManA)" 0 Mytilus edulis (Blue mussel) 367 mannan catabolic process [GO:0046355] GO:0016985; GO:0046355 0 0 0 PF00150; Q96MM6 CHOYP_BRAFLDRAFT_57788.3.10 m.31620 sp HS12B_HUMAN 34.621 647 349 18 7 594 54 685 2.54E-110 348 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_HS12A.17.33 m.51100 sp HS12B_HUMAN 27.813 640 381 16 38 610 60 685 2.54E-75 257 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99315 CHOYP_contig_032011 m.36492 sp YG31B_YEAST 50 128 63 1 338 465 616 742 2.54E-32 134 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9CW79 CHOYP_LOC100888300.2.2 m.24807 sp GOGA1_MOUSE 27.815 755 417 22 1 712 1 670 2.54E-45 178 GOGA1_MOUSE reviewed Golgin subfamily A member 1 (Golgin-97) Golga1 Mus musculus (Mouse) 758 protein targeting to Golgi [GO:0000042] GO:0000042; GO:0005794; GO:0005802; GO:0032580; GO:0043231; GO:0048471 0 0 0 PF01465; Q9GL24 CHOYP_CTSL2.1.2 m.2936 sp CATL1_CANLF 51.119 268 126 5 1 266 1 265 2.54E-96 291 CATL1_CANLF reviewed Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] CTSL CTSL1 Canis lupus familiaris (Dog) (Canis familiaris) 333 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0051603 0 0 0 PF08246;PF00112; Q9NLA3 CHOYP_LOC100215712.1.2 m.17662 sp ANO39_PATPE 34.066 91 54 1 104 188 2 92 2.54E-07 53.1 ANO39_PATPE reviewed Nucleoplasmin-like protein ANO39 (39 kDa oocyte-expressed nucleolar protein) (Nucleic acid-associated protein 36) (Nucleic acid-binding nuclear protein) (NAAP) (NAAP1) (NAAP2) 0 Patiria pectinifera (Starfish) (Asterina pectinifera) 346 mitotic nuclear division [GO:0007067]; oocyte maturation [GO:0001556] GO:0001556; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007067 0 0 0 PF16276;PF03066; Q9U3W6 CHOYP_NEMVEDRAFT_V1G218914.3.4 m.55337 sp MAB21_DROME 25.61 164 104 5 174 328 185 339 2.54E-07 57 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; Q9ULX7 CHOYP_LOC100375427.1.1 m.6282 sp CAH14_HUMAN 40.417 240 135 6 68 305 15 248 2.54E-48 177 CAH14_HUMAN reviewed Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV) CA14 UNQ690/PRO1335 Homo sapiens (Human) 337 bicarbonate transport [GO:0015701] GO:0004089; GO:0005886; GO:0015701; GO:0016021; GO:0046872 0 0 0 PF00194; Q9VEG6 CHOYP_LOC100646933.1.1 m.42867 sp PERC_DROME 37.097 558 328 10 246 793 225 769 2.54E-102 340 PERC_DROME reviewed Chorion peroxidase (EC 1.11.1.7) (Peroxinectin-related protein) (Dpxt) Pxt CG7660 Drosophila melanogaster (Fruit fly) 809 chorion-containing eggshell formation [GO:0007304]; eggshell chorion assembly [GO:0007306]; hydrogen peroxide catabolic process [GO:0042744]; hydrogen peroxide metabolic process [GO:0042743]; ovarian follicle cell development [GO:0030707]; prostaglandin biosynthetic process [GO:0001516]; response to oxidative stress [GO:0006979] GO:0001516; GO:0004601; GO:0004666; GO:0005615; GO:0005875; GO:0006979; GO:0007304; GO:0007306; GO:0020037; GO:0030707; GO:0042743; GO:0042744; GO:0046872 0 0 0 PF03098; Q9VZZ9 CHOYP_CPIPJ_CPIJ002084.1.1 m.41135 sp DOS_DROME 39.259 135 62 5 9 139 6 124 2.54E-20 89.7 DOS_DROME reviewed Protein daughter of sevenless dos CG1044 Drosophila melanogaster (Fruit fly) 878 "anterior/posterior axis specification, embryo [GO:0008595]; antimicrobial humoral response [GO:0019730]; photoreceptor cell development [GO:0042461]; regulation of Ras protein signal transduction [GO:0046578]; sevenless signaling pathway [GO:0045500]; torso signaling pathway [GO:0008293]; wing disc development [GO:0035220]" GO:0005070; GO:0005737; GO:0005886; GO:0008293; GO:0008595; GO:0019730; GO:0035220; GO:0042169; GO:0042461; GO:0045500; GO:0046578 0 0 0 PF00169; Q9XSK2 CHOYP_BRAFLDRAFT_124708.1.2 m.18355 sp CD63_BOVIN 31.429 140 91 3 32 171 103 237 2.54E-20 87.4 CD63_BOVIN reviewed CD63 antigen (CD antigen CD63) CD63 Bos taurus (Bovine) 237 cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endosome to melanosome transport [GO:0035646]; pigment granule maturation [GO:0048757]; positive regulation of endocytosis [GO:0045807]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005765; GO:0005887; GO:0007155; GO:0007160; GO:0007166; GO:0012505; GO:0015031; GO:0016477; GO:0031226; GO:0031902; GO:0035646; GO:0042470; GO:0045807; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2001046 0 0 0 PF00335; Q9Z1X9 CHOYP_LOC100374877.1.1 m.31097 sp CDC45_MOUSE 54.023 87 40 0 1 87 12 98 2.54E-28 110 CDC45_MOUSE reviewed Cell division control protein 45 homolog (PORC-PI-1) Cdc45 Cdc45l Cdc45l2 Mus musculus (Mouse) 566 DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; mitotic DNA replication preinitiation complex assembly [GO:1902977]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267]; regulation of chromatin silencing at telomere [GO:0031938] GO:0000727; GO:0003682; GO:0003688; GO:0003697; GO:0005634; GO:0005656; GO:0005813; GO:0006267; GO:0006270; GO:0031261; GO:0031298; GO:0031938; GO:0043138; GO:1900087; GO:1902977 0 0 0 PF02724; A4IGL7 CHOYP_HMCN1.44.44 m.67044 sp PXDN_XENTR 27.966 354 217 15 7 355 287 607 2.55E-29 124 PXDN_XENTR reviewed Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1457 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF03098;PF07679;PF13855;PF00093; A7X3Z7 CHOYP_NEMVEDRAFT_V1G238062.6.6 m.42189 sp LECM2_ERYPO 32.5 160 96 7 7 159 4 158 2.55E-17 79.3 LECM2_ERYPO reviewed C-type lectin lectoxin-Lio2 (CTL) 0 Erythrolamprus poecilogyrus (Water snake) (Liophis poecilogyrus) 163 0 GO:0005576; GO:0030246; GO:0046872 0 0 0 PF00059; A8QMS7 CHOYP_MYD88.2.7 m.21423 sp MYD88_TAKRU 35.017 297 168 9 15 307 13 288 2.55E-48 167 MYD88_TAKRU reviewed Myeloid differentiation primary response protein MyD88 myd88 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 288 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0002755; GO:0005737; GO:0006954; GO:0043123; GO:0045087 0 0 0 PF00531;PF01582; B3A0R6 CHOYP_ELDP2.1.2 m.39081 sp ELDP1_LOTGI 23.8 521 311 23 3 503 6 460 2.55E-24 110 ELDP1_LOTGI reviewed EGF-like domain-containing protein 1 (Uncharacterized shell protein 17) (LUSP-17) 0 Lottia gigantea (Giant owl limpet) 513 0 GO:0005576 0 0 0 0 O15050 CHOYP_TRANK1.3.9 m.21688 sp TRNK1_HUMAN 24.422 389 252 12 405 757 423 805 2.55E-14 81.3 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O17185 CHOYP_LOC100120322.1.3 m.1079 sp SUP9_CAEEL 60.39 308 110 4 1 306 1 298 2.55E-122 358 SUP9_CAEEL reviewed Two pore potassium channel protein sup-9 (Suppressor of unc-93 protein 9) (n2P38) sup-9 F34D6.3 Caenorhabditis elegans 329 potassium ion transport [GO:0006813]; regulation of muscle contraction [GO:0006937]; stabilization of membrane potential [GO:0030322] GO:0005267; GO:0005887; GO:0006813; GO:0006937; GO:0022841; GO:0030322; GO:0036195; GO:0055120 0 0 0 PF07885; O17185 CHOYP_LOC100120322.3.3 m.52428 sp SUP9_CAEEL 60.39 308 110 4 1 306 1 298 2.55E-122 358 SUP9_CAEEL reviewed Two pore potassium channel protein sup-9 (Suppressor of unc-93 protein 9) (n2P38) sup-9 F34D6.3 Caenorhabditis elegans 329 potassium ion transport [GO:0006813]; regulation of muscle contraction [GO:0006937]; stabilization of membrane potential [GO:0030322] GO:0005267; GO:0005887; GO:0006813; GO:0006937; GO:0022841; GO:0030322; GO:0036195; GO:0055120 0 0 0 PF07885; O75382 CHOYP_TRIM2.37.59 m.42012 sp TRIM3_HUMAN 24.632 272 174 13 86 340 486 743 2.55E-07 55.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88799 CHOYP_NEMVEDRAFT_V1G119771.1.1 m.13302 sp ZAN_MOUSE 33.493 209 129 3 35 234 798 1005 2.55E-11 68.2 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; P08953 CHOYP_AGAP_AGAP013027.1.1 m.25072 sp TOLL_DROME 39.344 183 97 7 11 188 824 997 2.55E-28 126 TOLL_DROME reviewed Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) 1097 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cell adhesion [GO:0007155]; defense response [GO:0006952]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; dorsal/ventral axis specification [GO:0009950]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; mitotic cytokinesis [GO:0000281]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; regulation of hemocyte differentiation [GO:0045610]; regulation of melanization defense response [GO:0035007]; response to bacterium [GO:0009617]; response to fungus [GO:0009620]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]; zygotic specification of dorsal/ventral axis [GO:0007352] GO:0000281; GO:0002229; GO:0004888; GO:0005737; GO:0005769; GO:0005886; GO:0006952; GO:0006955; GO:0006963; GO:0006967; GO:0007155; GO:0007352; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009617; GO:0009620; GO:0009880; GO:0009897; GO:0009950; GO:0009986; GO:0016021; GO:0016201; GO:0019730; GO:0019732; GO:0019955; GO:0030097; GO:0032154; GO:0035007; GO:0035172; GO:0042802; GO:0043234; GO:0045087; GO:0045610; GO:0045944; GO:0050830; GO:0050832; GO:0070976; GO:1902875 0 0 0 PF00560;PF13306;PF13855;PF01462;PF01582; P14618 CHOYP_LOC100371005.1.2 m.2526 sp KPYM_HUMAN 46.109 514 270 5 5 513 20 531 2.55E-158 464 KPYM_HUMAN reviewed Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) (Opa-interacting protein 3) (OIP-3) (Pyruvate kinase 2/3) (Pyruvate kinase muscle isozyme) (Thyroid hormone-binding protein 1) (THBP1) (Tumor M2-PK) (p58) PKM OIP3 PK2 PK3 PKM2 Homo sapiens (Human) 531 ATP biosynthetic process [GO:0006754]; canonical glycolysis [GO:0061621]; liver development [GO:0001889]; organ regeneration [GO:0031100]; programmed cell death [GO:0012501]; pyruvate biosynthetic process [GO:0042866]; response to gravity [GO:0009629]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; response to muscle inactivity [GO:0014870]; response to nutrient [GO:0007584]; skeletal muscle tissue regeneration [GO:0043403] GO:0000287; GO:0001666; GO:0001889; GO:0004743; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0005913; GO:0005929; GO:0006754; GO:0007584; GO:0009629; GO:0012501; GO:0014870; GO:0016301; GO:0023026; GO:0030955; GO:0031012; GO:0031100; GO:0031982; GO:0032868; GO:0042866; GO:0043209; GO:0043403; GO:0043531; GO:0044822; GO:0061621; GO:0070062; GO:0098641; GO:1903561 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. 0 0 PF00224;PF02887; P26652 CHOYP_TIMP3.8.9 m.48560 sp TIMP3_CHICK 32.447 188 109 8 20 203 22 195 2.55E-19 85.5 TIMP3_CHICK reviewed Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) 212 negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] GO:0002020; GO:0005578; GO:0005615; GO:0008191; GO:0010033; GO:0043086; GO:0046872; GO:0051045 0 0 0 PF00965; P40240 CHOYP_PHUM_PHUM332960.1.1 m.30377 sp CD9_MOUSE 29.412 272 144 5 1 272 1 224 2.55E-28 111 CD9_MOUSE reviewed CD9 antigen (CD antigen CD9) Cd9 Mus musculus (Mouse) 226 brain development [GO:0007420]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane [GO:0007342]; movement of cell or subcellular component [GO:0006928]; negative regulation of cell proliferation [GO:0008285]; oligodendrocyte development [GO:0014003]; paranodal junction assembly [GO:0030913]; receptor internalization [GO:0031623]; response to water deprivation [GO:0009414] GO:0005615; GO:0005886; GO:0005887; GO:0005925; GO:0006928; GO:0007155; GO:0007166; GO:0007342; GO:0007420; GO:0008285; GO:0009414; GO:0009897; GO:0014003; GO:0016020; GO:0016324; GO:0030913; GO:0031623; GO:0070062; GO:0071404; GO:1903561 0 0 0 PF00335; P62264 CHOYP_RS14.3.6 m.23057 sp RS14_MOUSE 89.13 138 14 1 15 151 3 140 2.55E-87 254 RS14_MOUSE reviewed 40S ribosomal protein S14 Rps14 Mus musculus (Mouse) 151 "erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]" GO:0000028; GO:0000122; GO:0000462; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005739; GO:0005925; GO:0006412; GO:0016020; GO:0022627; GO:0030218; GO:0030490; GO:0044822; GO:0045182; GO:0048027; GO:0070062; GO:0070181 0 0 0 PF00411; P98174 CHOYP_FGD1.2.2 m.34381 sp FGD1_HUMAN 42.857 553 286 10 544 1071 371 918 2.55E-132 429 FGD1_HUMAN reviewed "FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF) (Zinc finger FYVE domain-containing protein 3)" FGD1 FGDY ZFYVE3 Homo sapiens (Human) 961 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; multicellular organism development [GO:0007275]; organ morphogenesis [GO:0009887]; positive regulation of apoptotic process [GO:0043065]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0001726; GO:0005085; GO:0005089; GO:0005737; GO:0005794; GO:0005829; GO:0005856; GO:0007010; GO:0007165; GO:0007275; GO:0008360; GO:0009887; GO:0030027; GO:0030036; GO:0031267; GO:0035023; GO:0043065; GO:0043087; GO:0046847; GO:0046872; GO:0051056 0 0 0 PF01363;PF00169;PF00621; Q03601 CHOYP_BRAFLDRAFT_71595.1.4 m.13219 sp NHL1_CAEEL 29.358 109 67 3 56 154 772 880 2.55E-08 56.2 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q0VFN8 CHOYP_LOC100370453.1.1 m.48521 sp CF157_XENTR 45.328 503 244 9 1 495 1 480 2.55E-119 365 CF157_XENTR reviewed Cilia- and flagella-associated protein 157 cfap157 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 519 0 0 0 0 0 0 Q1LXZ7 CHOYP_IQCH.1.1 m.12658 sp IQCH_DANRE 29.665 209 106 7 9 213 9 180 2.55E-15 77.4 IQCH_DANRE reviewed IQ motif-containing protein H iqch si:dkey-246a16.2 Danio rerio (Zebrafish) (Brachydanio rerio) 1059 0 0 0 0 0 0 Q1ZXD6 CHOYP_BRAFLDRAFT_129004.8.15 m.42456 sp ROCO5_DICDI 28 175 94 7 486 657 1344 1489 2.55E-06 54.7 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q4R684 CHOYP_LOC100632148.1.1 m.14428 sp AMZ2_MACFA 31.627 332 145 12 43 352 41 312 2.55E-34 133 AMZ2_MACFA reviewed Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) AMZ2 QtsA-18820 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 360 0 GO:0008237; GO:0008270 0 0 cd11375; PF07998; Q54KD0 CHOYP_BRAFLDRAFT_122847.2.2 m.53154 sp Y7407_DICDI 25.965 1036 613 30 1247 2158 367 1372 2.55E-92 337 Y7407_DICDI reviewed TPR repeat-containing protein DDB_G0287407 DDB_G0287407 Dictyostelium discoideum (Slime mold) 1663 0 0 0 0 0 PF13271; Q5F489 CHOYP_LOC100372715.1.1 m.41763 sp TAF3_CHICK 49.612 129 65 0 1 129 1 129 2.55E-38 159 TAF3_CHICK reviewed Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) TAF3 RCJMB04_2c9 Gallus gallus (Chicken) 930 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF07524;PF00628; Q62193 CHOYP_RFA2.1.1 m.6290 sp RFA2_MOUSE 43.59 273 142 6 1 265 1 269 2.55E-74 230 RFA2_MOUSE reviewed Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) Rpa2 Rpa34 Mus musculus (Mouse) 270 base-excision repair [GO:0006284]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; mitotic G1 DNA damage checkpoint [GO:0031571]; nucleotide-excision repair [GO:0006289]; regulation of DNA damage checkpoint [GO:2000001]; regulation of double-strand break repair via homologous recombination [GO:0010569]; telomere maintenance [GO:0000723] GO:0000723; GO:0000724; GO:0000784; GO:0000785; GO:0003677; GO:0003684; GO:0003697; GO:0005634; GO:0005654; GO:0005662; GO:0006260; GO:0006284; GO:0006289; GO:0006298; GO:0010569; GO:0016605; GO:0019899; GO:0019903; GO:0031571; GO:0031625; GO:2000001 0 0 0 PF08784; Q6ZSS7 CHOYP_AAEL_AAEL011465.1.1 m.14754 sp MFSD6_HUMAN 42.857 77 44 0 15 91 64 140 2.55E-12 71.2 MFSD6_HUMAN reviewed Major facilitator superfamily domain-containing protein 6 (Macrophage MHC class I receptor 2 homolog) MFSD6 MMR2 Homo sapiens (Human) 791 0 GO:0016020; GO:0016021 0 0 cd06174; PF12832; Q75WF2 CHOYP_BM1_30865.1.1 m.35050 sp DNA2_ACAPL 30.925 346 212 9 74 395 7 349 2.55E-44 160 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q868Z9 CHOYP_DPSE_GA17283.3.3 m.59446 sp PPN_DROME 29.321 839 399 27 34 761 1611 2366 2.55E-78 290 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q8CIW5 CHOYP_PEO1.1.1 m.14775 sp PEO1_MOUSE 25.547 274 162 11 9 270 60 303 2.55E-10 63.9 PEO1_MOUSE reviewed "Twinkle protein, mitochondrial (EC 3.6.4.12) (Progressive external ophthalmoplegia 1 protein homolog) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase)" Peo1 Mus musculus (Mouse) 685 cellular response to glucose stimulus [GO:0071333]; DNA unwinding involved in DNA replication [GO:0006268]; mitochondrial DNA replication [GO:0006264]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; transcription from mitochondrial promoter [GO:0006390] GO:0002020; GO:0003678; GO:0003697; GO:0005524; GO:0005739; GO:0006264; GO:0006268; GO:0006390; GO:0034214; GO:0042645; GO:0043139; GO:0051260; GO:0071333 0 0 0 0 Q8VHT8 CHOYP_GTF3A.1.1 m.2567 sp TF3A_RAT 44.966 298 153 6 33 325 35 326 2.55E-71 232 TF3A_RAT reviewed Transcription factor IIIA (TFIIIA) Gtf3a Rattus norvegicus (Rat) 363 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0003723; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096; Q8WNR9 CHOYP_LOC100555907.1.1 m.27452 sp CYTA_FELCA 33.784 74 43 2 26 99 2 69 2.55E-09 53.9 CYTA_FELCA reviewed "Cystatin-A (allergen Fel d 3) [Cleaved into: Cystatin-A, N-terminally processed]" CSTA Felis catus (Cat) (Felis silvestris catus) 98 0 GO:0004869; GO:0005737 0 0 0 PF00031; Q93104 CHOYP_E_R_.1.1 m.63122 sp ERH_AEDAE 77 100 23 0 1 100 1 100 2.55E-57 174 ERH_AEDAE reviewed Enhancer of rudimentary homolog 0 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 103 cell cycle [GO:0007049]; positive regulation of Notch signaling pathway [GO:0045747]; pyrimidine nucleotide biosynthetic process [GO:0006221] GO:0006221; GO:0007049; GO:0045747 0 0 0 PF01133; Q94126 CHOYP_LOC100378028.1.1 m.7463 sp CES2_CAEEL 53.947 76 35 0 164 239 102 177 2.55E-18 83.6 CES2_CAEEL reviewed Cell death specification protein 2 ces-2 ZK909.4 Caenorhabditis elegans 211 apoptotic process [GO:0006915]; multicellular organism development [GO:0007275]; positive regulation of programmed cell death [GO:0043068] GO:0000977; GO:0001012; GO:0001077; GO:0003700; GO:0005634; GO:0006915; GO:0007275; GO:0043068; GO:0043565 0 0 0 PF07716; Q96GM8 CHOYP_BRAFLDRAFT_287482.1.1 m.8446 sp TOE1_HUMAN 37.773 503 220 13 16 465 42 504 2.55E-106 328 TOE1_HUMAN reviewed Target of EGR1 protein 1 TOE1 Homo sapiens (Human) 510 "RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]" GO:0000175; GO:0003676; GO:0004535; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0015030; GO:0016607; GO:0046872; GO:0090503 0 0 0 PF04857;PF00642; Q9CYL5 CHOYP_BRAFLDRAFT_86052.1.1 m.25460 sp GAPR1_MOUSE 48 150 70 4 24 171 9 152 2.55E-38 139 GAPR1_MOUSE reviewed Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) Glipr2 Gapr1 Mus musculus (Mouse) 154 positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374 0 0 0 PF00188; Q9EPR2 CHOYP_LOC100116717.2.2 m.30034 sp PG12A_MOUSE 35.329 167 101 5 18 180 21 184 2.55E-26 105 PG12A_MOUSE reviewed Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) Pla2g12a Pla2g12 Mus musculus (Mouse) 192 lipid catabolic process [GO:0016042] GO:0004623; GO:0005509; GO:0005576; GO:0005622; GO:0005783; GO:0005794; GO:0016042 0 0 0 PF06951; Q9ESN6 CHOYP_TRIM2.5.59 m.8080 sp TRIM2_MOUSE 27.376 263 156 11 41 282 489 737 2.55E-15 79.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM3.54.58 m.60177 sp TRIM2_MOUSE 29.902 204 128 8 77 273 536 731 2.55E-10 64.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y5H6 CHOYP_PCDHGA11.1.1 m.4782 sp PCDA8_HUMAN 35.185 162 100 3 87 248 189 345 2.55E-22 100 PCDA8_HUMAN reviewed Protocadherin alpha-8 (PCDH-alpha-8) PCDHA8 Homo sapiens (Human) 950 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] GO:0005509; GO:0005887; GO:0007155; GO:0007156; GO:0007399 0 0 0 PF00028;PF08266;PF15974; A2VDR2 CHOYP_BRAFLDRAFT_69053.1.1 m.35992 sp ACBD6_BOVIN 40.586 239 136 2 16 249 42 279 2.56E-60 194 ACBD6_BOVIN reviewed Acyl-CoA-binding domain-containing protein 6 ACBD6 Bos taurus (Bovine) 282 0 GO:0000062; GO:0005737; GO:0008289 0 0 0 PF00887;PF12796; G3V801 CHOYP_BRAFLDRAFT_243719.1.2 m.39163 sp NETR_RAT 50.714 140 66 3 335 473 165 302 2.56E-40 157 NETR_RAT reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) Prss12 Rattus norvegicus (Rat) 761 exocytosis [GO:0006887]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006887; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195 0 0 cd00190; PF00051;PF00530;PF00089; O08863 CHOYP_BIRC3.6.7 m.56198 sp BIRC3_MOUSE 49.231 65 29 2 53 117 540 600 2.56E-13 68.2 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; O35586 CHOYP_BRAFLDRAFT_76431.2.2 m.61957 sp IDI1_MESAU 60.894 179 67 1 42 220 10 185 2.56E-76 233 IDI1_MESAU reviewed Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1) IDI1 Mesocricetus auratus (Golden hamster) 227 cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isoprenoid biosynthetic process [GO:0008299] GO:0004452; GO:0005777; GO:0006695; GO:0008299; GO:0016787; GO:0046872; GO:0050992 PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. 0 cd02885; PF00293; O43301 CHOYP_LOC100372773.7.9 m.63633 sp HS12A_HUMAN 27.527 643 374 20 52 621 49 672 2.56E-62 221 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P04464 CHOYP_CALM.34.50 m.49651 sp CALM_WHEAT 54.676 139 62 1 20 158 12 149 2.56E-45 148 CALM_WHEAT reviewed Calmodulin (CaM) 0 Triticum aestivum (Wheat) 149 0 GO:0005509 0 0 0 PF13499; P16157 CHOYP_contig_028913 m.32845 sp ANK1_HUMAN 34.688 320 183 4 81 396 206 503 2.56E-47 177 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17978 CHOYP_BRAFLDRAFT_241726.4.22 m.3766 sp VGB_STAAU 25.743 202 125 8 9 193 89 282 2.56E-08 57 VGB_STAAU reviewed Virginiamycin B lyase (EC 4.2.99.-) (Streptogramin B lyase) vgb vgh Staphylococcus aureus 299 antibiotic catabolic process [GO:0017001]; response to antibiotic [GO:0046677] GO:0000287; GO:0016835; GO:0017001; GO:0046677 0 0 0 0 P21333 CHOYP_LOC100204838.1.1 m.4047 sp FLNA_HUMAN 27.21 1165 729 35 9 1093 29 1154 2.56E-90 323 FLNA_HUMAN reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) FLNA FLN FLN1 Homo sapiens (Human) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; cell junction assembly [GO:0034329]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; establishment of protein localization [GO:0045184]; mitotic spindle assembly [GO:0090307]; mRNA transcription from RNA polymerase II promoter [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001664; GO:0001948; GO:0002576; GO:0004871; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005884; GO:0005886; GO:0005911; GO:0005913; GO:0005925; GO:0007195; GO:0008134; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030168; GO:0030334; GO:0030863; GO:0031012; GO:0031267; GO:0031523; GO:0031532; GO:0034329; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042789; GO:0042803; GO:0042993; GO:0043025; GO:0043066; GO:0043113; GO:0043123; GO:0043198; GO:0043433; GO:0044319; GO:0044822; GO:0045184; GO:0048365; GO:0048471; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:0097440; GO:0098641; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; P22129 CHOYP_RB11B.1.1 m.22118 sp RB11B_DIPOM 58.411 214 77 2 1 202 1 214 2.56E-88 261 RB11B_DIPOM reviewed Ras-related protein Rab-11B (ORA3) 0 Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) 218 "cellular response to acidic pH [GO:0071468]; constitutive secretory pathway [GO:0045054]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; melanosome transport [GO:0032402]; receptor recycling [GO:0001881]; regulated exocytosis [GO:0045055]; regulation of anion transport [GO:0044070]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to plasma membrane [GO:1990126]; small GTPase mediated signal transduction [GO:0007264]; transferrin transport [GO:0033572]" GO:0001881; GO:0003924; GO:0005525; GO:0007264; GO:0008021; GO:0019003; GO:0030054; GO:0030670; GO:0030672; GO:0032402; GO:0033572; GO:0035773; GO:0044070; GO:0045054; GO:0045055; GO:0045335; GO:0055038; GO:0071468; GO:1990126; GO:2000008; GO:2001135 0 0 0 PF00071; P27089 CHOYP_XPA.1.1 m.61554 sp XPA_CHICK 52.107 261 117 6 7 264 5 260 2.56E-73 228 XPA_CHICK reviewed DNA repair protein complementing XP-A cells homolog (Xeroderma pigmentosum group A-complementing protein homolog) XPA XPAC Gallus gallus (Chicken) 267 "base-excision repair [GO:0006284]; DNA repair [GO:0006281]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; UV-damage excision repair [GO:0070914]" GO:0000110; GO:0000715; GO:0003684; GO:0005654; GO:0006281; GO:0006284; GO:0033683; GO:0046872; GO:0070914; GO:1901255 0 0 0 PF05181;PF01286; P27671 CHOYP_LOC574811.2.2 m.44768 sp RGRF1_MOUSE 71.377 276 77 2 1 274 243 518 2.56E-128 399 RGRF1_MOUSE reviewed Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (CDC25Mm) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25) Rasgrf1 Cdc25 Grf1 Mus musculus (Mouse) 1262 activation of GTPase activity [GO:0090630]; cell proliferation [GO:0008283]; neuron projection development [GO:0031175]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310]; regulation of Rac protein signal transduction [GO:0035020]; regulation of Ras protein signal transduction [GO:0046578]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic plasticity [GO:0048167]; small GTPase mediated signal transduction [GO:0007264] GO:0005089; GO:0005829; GO:0007264; GO:0008283; GO:0030426; GO:0031175; GO:0035020; GO:0035023; GO:0035254; GO:0043547; GO:0046578; GO:0046579; GO:0048167; GO:0048168; GO:0090630; GO:2000310 0 0 0 PF00169;PF00617;PF00618;PF00621; P37889 CHOYP_FBLN2.1.1 m.25187 sp FBLN2_MOUSE 35.673 869 410 30 21 809 418 1217 2.56E-134 432 FBLN2_MOUSE reviewed Fibulin-2 (FIBL-2) Fbln2 Mus musculus (Mouse) 1221 positive regulation of cell-substrate adhesion [GO:0010811] GO:0005509; GO:0005578; GO:0010811; GO:0031012; GO:0050840; GO:0070062; GO:1903561 0 0 0 PF01821;PF12662;PF07645; P40237 CHOYP_LOC100370603.1.1 m.51092 sp CD82_MOUSE 25.287 261 160 9 22 275 26 258 2.56E-13 71.6 CD82_MOUSE reviewed CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82) Cd82 Kai1 Mus musculus (Mouse) 266 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166; GO:0070062 0 0 0 PF00335; P41436 CHOYP_IAP1.4.4 m.56082 sp IAP_GVCPM 48.421 95 49 0 211 305 100 194 2.56E-26 108 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P48597 CHOYP_IF4E.1.1 m.56823 sp IF4E_XENLA 66.832 202 67 0 14 215 12 213 2.56E-103 300 IF4E_XENLA reviewed Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) eif4e Xenopus laevis (African clawed frog) 213 regulation of translation [GO:0006417] GO:0003743; GO:0005845; GO:0006417; GO:0016281; GO:0043234 0 0 0 PF01652; P61354 CHOYP_LOC100222774.1.1 m.56992 sp RL27_RAT 81.818 132 24 0 1 132 5 136 2.56E-76 225 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; P86854 CHOYP_MRC1.2.4 m.22571 sp PLCL_MYTGA 23.81 126 88 4 29 153 30 148 2.56E-08 53.5 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q09575 CHOYP_LOC578054.5.7 m.28465 sp YRD6_CAEEL 30.328 244 156 5 463 705 775 1005 2.56E-28 125 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q11212 CHOYP_ACTC.4.6 m.25287 sp ACT_SPOLI 65.385 78 20 2 2 79 7 77 2.56E-24 93.2 ACT_SPOLI reviewed Actin (Fragment) 0 Spodoptera littoralis (Egyptian cotton leafworm) 164 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q13231 CHOYP_LOC100368238.1.1 m.7505 sp CHIT1_HUMAN 41.887 530 230 9 12 537 10 465 2.56E-137 416 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q15648 CHOYP_LOC658743.1.1 m.13717 sp MED1_HUMAN 36.973 522 304 13 33 537 20 533 2.56E-87 320 MED1_HUMAN reviewed Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2 Homo sapiens (Human) 1581 "androgen biosynthetic process [GO:0006702]; androgen receptor signaling pathway [GO:0030521]; angiogenesis [GO:0001525]; brain development [GO:0007420]; cell morphogenesis [GO:0000902]; cellular lipid metabolic process [GO:0044255]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to steroid hormone stimulus [GO:0071383]; cellular response to thyroid hormone stimulus [GO:0097067]; embryonic heart tube development [GO:0035050]; embryonic hemopoiesis [GO:0035162]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic placenta development [GO:0001892]; enucleate erythrocyte development [GO:0048822]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; ERK1 and ERK2 cascade [GO:0070371]; erythrocyte development [GO:0048821]; fat cell differentiation [GO:0045444]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; keratinocyte differentiation [GO:0030216]; lactation [GO:0007595]; lens development in camera-type eye [GO:0002088]; liver development [GO:0001889]; mammary gland branching involved in pregnancy [GO:0060745]; mammary gland branching involved in thelarche [GO:0060744]; megakaryocyte development [GO:0035855]; monocyte differentiation [GO:0030224]; mRNA transcription from RNA polymerase II promoter [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; organ regeneration [GO:0031100]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of G0 to G1 transition [GO:0070318]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of interferon-gamma-mediated signaling pathway [GO:0060335]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of mammary gland epithelial cell proliferation [GO:0033601]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of receptor activity [GO:2000273]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle [GO:0051726]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription from RNA polymerase I promoter [GO:0006356]; regulation of vitamin D receptor signaling pathway [GO:0070562]; retinal pigment epithelium development [GO:0003406]; thyroid hormone generation [GO:0006590]; thyroid hormone mediated signaling pathway [GO:0002154]; transcription initiation from RNA polymerase II promoter [GO:0006367]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0000151; GO:0000785; GO:0000902; GO:0000978; GO:0000981; GO:0001047; GO:0001104; GO:0001525; GO:0001889; GO:0001892; GO:0002088; GO:0002154; GO:0003222; GO:0003406; GO:0003682; GO:0003712; GO:0003713; GO:0004872; GO:0005634; GO:0005654; GO:0005730; GO:0006356; GO:0006367; GO:0006590; GO:0006702; GO:0007420; GO:0007595; GO:0008134; GO:0010628; GO:0010839; GO:0016020; GO:0016592; GO:0016922; GO:0030216; GO:0030224; GO:0030331; GO:0030374; GO:0030375; GO:0030518; GO:0030521; GO:0031100; GO:0031490; GO:0032993; GO:0033148; GO:0033160; GO:0033601; GO:0035050; GO:0035116; GO:0035162; GO:0035257; GO:0035357; GO:0035729; GO:0035855; GO:0036033; GO:0042789; GO:0042809; GO:0042974; GO:0042975; GO:0043066; GO:0044255; GO:0045444; GO:0045618; GO:0045648; GO:0045665; GO:0045893; GO:0045944; GO:0046966; GO:0048821; GO:0048822; GO:0050693; GO:0051726; GO:0060335; GO:0060744; GO:0060745; GO:0060750; GO:0061630; GO:0070318; GO:0070371; GO:0070562; GO:0071364; GO:0071383; GO:0097067; GO:2000273; GO:2000347; GO:2001141 0 0 0 PF10744; Q1W374 CHOYP_BRAFLDRAFT_113552.1.1 m.29171 sp PMM_WHEAT 57.085 247 104 1 17 263 1 245 2.56E-107 313 PMM_WHEAT reviewed Phosphomannomutase (EC 5.4.2.8) (TaPMM) 0 Triticum aestivum (Wheat) 249 GDP-mannose biosynthetic process [GO:0009298] GO:0004615; GO:0005737; GO:0009298 PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2. 0 0 PF03332; Q1XI86 CHOYP_PCYB_111030.1.2 m.2990 sp IMPG2_CHICK 25.413 303 185 15 127 414 1055 1331 2.56E-06 54.7 IMPG2_CHICK reviewed Interphotoreceptor matrix proteoglycan 2 (Sialoprotein associated with cones and rods proteoglycan) (Spacrcan) IMPG2 Gallus gallus (Chicken) 1423 visual perception [GO:0007601] GO:0005201; GO:0005540; GO:0007601; GO:0008201; GO:0016021; GO:0033165 0 0 0 PF01390; Q3T0S0 CHOYP_BRAFLDRAFT_78425.1.1 m.10136 sp TM128_BOVIN 30.939 181 108 5 17 197 1 164 2.56E-24 96.7 TM128_BOVIN reviewed Transmembrane protein 128 TMEM128 Bos taurus (Bovine) 165 0 GO:0016021 0 0 0 0 Q7TPQ3 CHOYP_BRAFLDRAFT_125252.1.1 m.14950 sp SHPRH_MOUSE 46.094 128 65 1 56 183 267 390 2.56E-24 111 SHPRH_MOUSE reviewed "E3 ubiquitin-protein ligase SHPRH (EC 3.6.4.-) (EC 6.3.2.-) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)" Shprh Mus musculus (Mouse) 1674 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; nucleosome assembly [GO:0006334]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0000786; GO:0003677; GO:0004386; GO:0004842; GO:0005524; GO:0005634; GO:0006281; GO:0006334; GO:0006974; GO:0008270; GO:0016874; GO:0031625 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00271;PF00538;PF00176; Q86QH9 CHOYP_YBEY.1.1 m.48437 sp H1L1_OSTED 67.327 101 27 3 87 186 24 119 2.56E-33 124 H1L1_OSTED reviewed Sperm-specific H1/protamine-like protein type 1 [Cleaved into: Sperm-specific protein OE1 (Sperm-specific linker histone H1-like protein OE1); Sperm-specific protein OE3 (Protamine-like OS3)] 0 Ostrea edulis (Native oyster) (European flat oyster) 202 cell differentiation [GO:0030154]; chromosome condensation [GO:0030261]; multicellular organism development [GO:0007275]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0007275; GO:0007283; GO:0030154; GO:0030261 0 0 0 PF00538; Q8MQJ9 CHOYP_contig_040708 m.46264 sp BRAT_DROME 25.434 173 107 7 52 216 788 946 2.56E-07 53.9 BRAT_DROME reviewed Brain tumor protein brat CG10719 Drosophila melanogaster (Fruit fly) 1037 asymmetric cell division [GO:0008356]; asymmetric neuroblast division resulting in ganglion mother cell formation [GO:0055060]; axon guidance [GO:0007411]; brain development [GO:0007420]; ganglion mother cell fate determination [GO:0007402]; negative regulation of cell proliferation [GO:0008285]; negative regulation of neuroblast proliferation [GO:0007406]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; oogenesis [GO:0048477]; phagocytosis [GO:0006909]; regulation of neurogenesis [GO:0050767]; regulation of synaptic growth at neuromuscular junction [GO:0008582]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of translation [GO:0006417]; rRNA transcription [GO:0009303]; segmentation [GO:0035282]; ventral cord development [GO:0007419] GO:0005737; GO:0006417; GO:0006909; GO:0007400; GO:0007402; GO:0007405; GO:0007406; GO:0007411; GO:0007419; GO:0007420; GO:0008270; GO:0008285; GO:0008356; GO:0008582; GO:0009303; GO:0022008; GO:0030182; GO:0030371; GO:0035282; GO:0043025; GO:0045182; GO:0048477; GO:0050767; GO:0055060; GO:1900242 0 0 0 PF01436;PF00643; Q93015 CHOYP_LOC100498314.1.1 m.18667 sp NAT6_HUMAN 41.892 148 83 1 7 151 65 212 2.56E-41 144 NAT6_HUMAN reviewed N-acetyltransferase 6 (EC 2.3.1.-) (Protein fusion-2) (Protein fus-2) NAT6 FUS2 Homo sapiens (Human) 286 0 GO:0005737; GO:0008080 0 0 0 PF00583; Q96RW7 CHOYP_HMCN1.34.44 m.58941 sp HMCN1_HUMAN 25.508 1525 910 64 8 1463 639 2006 2.56E-86 319 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9EPB1 CHOYP_BRAFLDRAFT_128878.1.1 m.42339 sp DPP2_RAT 52.009 448 213 2 25 471 41 487 2.56E-170 491 DPP2_RAT reviewed Dipeptidyl peptidase 2 (EC 3.4.14.2) (Dipeptidyl aminopeptidase II) (Dipeptidyl peptidase 7) (Dipeptidyl peptidase II) (DPP II) (Quiescent cell proline dipeptidase) Dpp7 Dpp2 Rattus norvegicus (Rat) 500 proteolysis [GO:0006508] GO:0004185; GO:0005764; GO:0005794; GO:0005829; GO:0006508; GO:0008239; GO:0016023; GO:0031982; GO:0070062 0 0 0 PF05577; Q9ESN6 CHOYP_TRIM3.8.58 m.8078 sp TRIM2_MOUSE 25.778 225 149 8 214 428 489 705 2.56E-09 62.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9R0A8 CHOYP_LOC100374365.2.2 m.36964 sp HAUS1_RAT 30.483 269 186 1 45 312 10 278 2.56E-38 139 HAUS1_RAT reviewed HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) Haus1 Ccdc5 Rattus norvegicus (Rat) 278 cell division [GO:0051301]; centrosome organization [GO:0051297]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0000922; GO:0005737; GO:0005815; GO:0005874; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 0 Q9UMX1 CHOYP_LOC100313743.1.2 m.31178 sp SUFU_HUMAN 70.192 104 27 1 23 126 62 161 2.56E-44 153 SUFU_HUMAN reviewed Suppressor of fused homolog (SUFUH) SUFU UNQ650/PRO1280 Homo sapiens (Human) 484 "aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; cytoplasmic sequestering of transcription factor [GO:0042994]; heart looping [GO:0001947]; multicellular organism development [GO:0007275]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of transcription factor import into nucleus [GO:0042992]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube closure [GO:0001843]; proteolysis [GO:0006508]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; skin development [GO:0043588]; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [GO:0021776]; smoothened signaling pathway involved in ventral spinal cord interneuron specification [GO:0021775]; ventricular septum development [GO:0003281]" GO:0000122; GO:0001501; GO:0001843; GO:0001947; GO:0003281; GO:0003714; GO:0004871; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006355; GO:0006508; GO:0007165; GO:0007275; GO:0008134; GO:0019901; GO:0021775; GO:0021776; GO:0035904; GO:0042992; GO:0042994; GO:0043433; GO:0043588; GO:0045668; GO:0045879; GO:0060976; GO:0072372; GO:0097542; GO:0097546; GO:1901621; GO:2000059 0 0 0 PF05076;PF12470; Q9XWD6 CHOYP_MEG10.39.91 m.40348 sp CED1_CAEEL 44.186 86 42 4 80 164 679 759 2.56E-10 61.6 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; A0JPI9 CHOYP_LOC100372392.6.8 m.56267 sp LR74A_RAT 31.07 486 306 8 93 571 5 468 2.57E-73 245 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A2AJ76 CHOYP_LOC590125.4.7 m.40449 sp HMCN2_MOUSE 37.838 148 71 10 10 146 4653 4790 2.57E-17 83.2 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A4IIK1 CHOYP_BRAFLDRAFT_75632.1.1 m.60676 sp MFHA1_XENTR 26.589 944 596 25 102 1005 88 974 2.57E-78 283 MFHA1_XENTR reviewed Malignant fibrous histiocytoma-amplified sequence 1 homolog mfhas1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 997 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF16095;PF13855;PF08477; A5PLK2 CHOYP_BRAFLDRAFT_233674.1.1 m.66738 sp LHPP_DANRE 58.755 257 104 1 8 262 11 267 2.57E-110 322 LHPP_DANRE reviewed Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (EC 3.1.3.-) (EC 3.6.1.1) lhpp zgc:165670 Danio rerio (Zebrafish) (Brachydanio rerio) 270 phosphate-containing compound metabolic process [GO:0006796]; protein dephosphorylation [GO:0006470] GO:0000287; GO:0004427; GO:0005634; GO:0005829; GO:0006470; GO:0006796; GO:0008969 0 0 0 PF13344; A6QP70 CHOYP_BRAFLDRAFT_276577.1.1 m.9360 sp SGCB_BOVIN 29.553 291 172 10 18 295 28 298 2.57E-27 111 SGCB_BOVIN reviewed Beta-sarcoglycan (Beta-SG) SGCB Bos taurus (Bovine) 317 cardiac muscle cell development [GO:0055013]; membrane organization [GO:0061024]; muscle fiber development [GO:0048747]; muscle organ development [GO:0007517]; vascular smooth muscle cell development [GO:0097084] GO:0005737; GO:0005856; GO:0007517; GO:0016012; GO:0016021; GO:0042383; GO:0048747; GO:0055013; GO:0061024; GO:0097084 0 0 0 PF04790; B1AQJ2 CHOYP_USP36.2.2 m.48544 sp UBP36_MOUSE 42.623 549 257 9 12 532 3 521 2.57E-137 446 UBP36_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) Usp36 Kiaa1453 Mus musculus (Mouse) 1098 positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; regulation of mitophagy [GO:1903146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005634; GO:0005730; GO:0006511; GO:0016579; GO:0044822; GO:1903146; GO:1903955 0 0 0 PF00443; B9EQ30 CHOYP_LOC100376200.1.1 m.19157 sp SOSSC_SALSA 47.17 106 49 3 10 114 1 100 2.57E-23 89.7 SOSSC_SALSA reviewed SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) inip ssbip1 Salmo salar (Atlantic salmon) 107 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; response to ionizing radiation [GO:0010212] GO:0005634; GO:0006281; GO:0006974; GO:0010212; GO:0070876 0 0 0 PF15925; O08893 CHOYP_CALCR.6.6 m.62289 sp CALCR_CAVPO 36.243 378 222 12 11 383 45 408 2.57E-76 248 CALCR_CAVPO reviewed Calcitonin receptor (CT-R) CALCR Cavia porcellus (Guinea pig) 478 cell surface receptor signaling pathway [GO:0007166] GO:0004948; GO:0005886; GO:0007166; GO:0016021 0 0 0 PF00002;PF02793; O14522 CHOYP_PTPRT.33.45 m.55483 sp PTPRT_HUMAN 26.769 325 221 7 1 311 1119 1440 2.57E-22 101 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O16011 CHOYP_LOC100165326.1.1 m.45448 sp MBL_DROME 54.438 169 45 6 1 169 1 137 2.57E-50 167 MBL_DROME reviewed Protein muscleblind (Protein mindmelt) mbl mm CG33197 Drosophila melanogaster (Fruit fly) 297 "apoptotic process [GO:0006915]; compound eye photoreceptor cell differentiation [GO:0001751]; embryo development [GO:0009790]; eye development [GO:0001654]; imaginal disc-derived wing morphogenesis [GO:0007476]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; peripheral nervous system development [GO:0007422]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of female receptivity [GO:0045924]; regulation of gene expression [GO:0010468]; response to stimulus [GO:0050896]; rhabdomere development [GO:0042052]; somatic muscle development [GO:0007525]; visual perception [GO:0007601]" GO:0000381; GO:0001654; GO:0001751; GO:0003676; GO:0003677; GO:0005634; GO:0005737; GO:0006915; GO:0007422; GO:0007476; GO:0007517; GO:0007525; GO:0007601; GO:0009790; GO:0010468; GO:0030018; GO:0031673; GO:0042052; GO:0045924; GO:0046716; GO:0046872; GO:0048471; GO:0050896 0 0 0 0 P00748 CHOYP_CFAI.1.1 m.51561 sp FA12_HUMAN 27.957 279 150 14 163 400 336 604 2.57E-14 81.6 FA12_HUMAN reviewed Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)] F12 Homo sapiens (Human) 615 "blood coagulation, intrinsic pathway [GO:0007597]; Factor XII activation [GO:0002542]; fibrinolysis [GO:0042730]; innate immune response [GO:0045087]; plasma kallikrein-kinin cascade [GO:0002353]; positive regulation of blood coagulation [GO:0030194]; positive regulation of fibrinolysis [GO:0051919]; positive regulation of plasminogen activation [GO:0010756]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; response to misfolded protein [GO:0051788]; zymogen activation [GO:0031638]" GO:0002353; GO:0002542; GO:0004252; GO:0005509; GO:0005576; GO:0005615; GO:0005886; GO:0007597; GO:0010756; GO:0016485; GO:0016540; GO:0030194; GO:0031638; GO:0042730; GO:0045087; GO:0051787; GO:0051788; GO:0051919; GO:0070062 0 0 cd00062;cd00190; PF00008;PF00039;PF00040;PF00051;PF00089; P02553 CHOYP_DERE_GG14119.1.1 m.39864 sp TBA_LYTPI 97.561 82 2 0 48 129 57 138 2.57E-51 174 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P23754 CHOYP_H2B4.1.1 m.14916 sp H2B_EMENI 64.486 107 38 0 33 139 31 137 2.57E-45 147 H2B_EMENI reviewed Histone H2B htbA htb1 AN3469 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 140 nucleosome assembly [GO:0006334] GO:0000788; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00125; P86854 CHOYP_LOC100199985.1.1 m.28849 sp PLCL_MYTGA 33.784 148 93 5 1 146 12 156 2.57E-23 92.8 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q08420 CHOYP_LOC101169658.3.3 m.46969 sp SODE_RAT 24.862 181 116 6 20 186 48 222 2.57E-10 60.8 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q13310 CHOYP_LOC100370010.2.5 m.14471 sp PABP4_HUMAN 51.724 203 79 4 4 197 431 623 2.57E-41 150 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q1MSJ5 CHOYP_CSPP1.3.14 m.12753 sp CSPP1_HUMAN 33.85 709 370 22 571 1212 549 1225 2.57E-49 195 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q26481 CHOYP_RL5.4.4 m.63060 sp RL5_STYCL 76.552 290 67 1 1 290 1 289 2.57E-164 464 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q28623 CHOYP_SLMAP.8.8 m.65531 sp SLMAP_RABIT 60.471 382 141 4 16 390 3 381 2.57E-146 457 SLMAP_RABIT reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP SLAP Oryctolagus cuniculus (Rabbit) 771 muscle contraction [GO:0006936] GO:0005615; GO:0005737; GO:0005815; GO:0006936; GO:0016021; GO:0042383 0 0 0 PF00498; Q32PI1 CHOYP_VRK1.1.1 m.10917 sp VRK1_BOVIN 49.507 406 192 5 1 403 1 396 2.57E-139 409 VRK1_BOVIN reviewed Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) VRK1 Bos taurus (Bovine) 396 cell division [GO:0051301]; Golgi disassembly [GO:0090166]; mitotic nuclear division [GO:0007067]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005795; GO:0005819; GO:0006468; GO:0007067; GO:0008360; GO:0018105; GO:0046777; GO:0051301; GO:0090166 0 0 0 PF00069; Q53G44 CHOYP_LOC100377780.7.11 m.50971 sp IF44L_HUMAN 27.293 458 296 11 5 454 7 435 2.57E-48 175 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5E9P3 CHOYP_MC5R.2.2 m.46391 sp S1PR1_BOVIN 24.702 336 202 16 68 383 51 355 2.57E-12 72 S1PR1_BOVIN reviewed Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) S1PR1 EDG1 Bos taurus (Bovine) 382 actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; brain development [GO:0007420]; cardiac muscle tissue growth involved in heart morphogenesis [GO:0003245]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; heart trabecula morphogenesis [GO:0061384]; lamellipodium assembly [GO:0030032]; positive regulation of cell proliferation [GO:0008284]; regulation of bone mineralization [GO:0030500]; regulation of bone resorption [GO:0045124]; regulation of cell adhesion [GO:0030155]; sphingosine-1-phosphate signaling pathway [GO:0003376]; T cell migration [GO:0072678] GO:0001525; GO:0001955; GO:0003245; GO:0003376; GO:0005768; GO:0006935; GO:0007193; GO:0007420; GO:0008284; GO:0009897; GO:0016021; GO:0016477; GO:0030032; GO:0030155; GO:0030500; GO:0031226; GO:0031532; GO:0038036; GO:0045121; GO:0045124; GO:0061384; GO:0072678 0 0 0 PF00001; Q5R6Q2 CHOYP_LOC100367266.1.1 m.10803 sp STX6_PONAB 52.72 239 107 1 1 233 1 239 2.57E-91 272 STX6_PONAB reviewed Syntaxin-6 STX6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 255 Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025] GO:0000139; GO:0006886; GO:0016021; GO:0048193; GO:0061025 0 0 0 PF05739;PF09177; Q6H236 CHOYP_contig_014406 m.16502 sp PEG3_BOVIN 43.548 248 104 16 56 282 1292 1524 2.57E-10 64.7 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q8IDX6 CHOYP_ENS.3.3 m.61984 sp RBP2A_PLAF7 42.748 131 57 4 631 748 2740 2865 2.57E-09 65.5 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8K2J9 CHOYP_BTBD6.2.6 m.18294 sp BTBD6_MOUSE 35.811 444 254 10 8 445 64 482 2.57E-81 262 BTBD6_MOUSE reviewed BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) 488 0 GO:0000932 0 0 0 PF07707;PF00651;PF08005; Q91XN4 CHOYP_MGC81574.1.1 m.8983 sp BAMBI_RAT 33.333 216 120 10 12 225 12 205 2.57E-28 112 BAMBI_RAT reviewed BMP and activin membrane-bound inhibitor homolog (Kinase-deficient TGFbeta superfamily receptor subunit) Bambi Rattus norvegicus (Rat) 260 "cell migration [GO:0016477]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of cell proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell shape [GO:0008360]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0005737; GO:0005886; GO:0007179; GO:0008284; GO:0008360; GO:0010718; GO:0016021; GO:0016477; GO:0030512; GO:0032092; GO:0035413; GO:0045893; GO:0090263 0 0 0 PF06211; Q95KU9 CHOYP_contig_019956 m.23217 sp NEMO_BOVIN 32.039 103 68 2 20 122 237 337 2.57E-06 49.3 NEMO_BOVIN reviewed NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) IKBKG NEMO Bos taurus (Bovine) 419 "cellular response to DNA damage stimulus [GO:0006974]; establishment of vesicle localization [GO:0051650]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000922; GO:0005634; GO:0006351; GO:0006974; GO:0008385; GO:0042803; GO:0043123; GO:0045944; GO:0046872; GO:0046982; GO:0051092; GO:0051650; GO:0070530; GO:0072686 0 0 0 PF16516;PF11577; Q96MM6 CHOYP_HSPA12A.18.27 m.54182 sp HS12B_HUMAN 35.016 634 341 16 5 577 61 684 2.57E-118 369 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q98880 CHOYP_BRAFLDRAFT_64442.2.2 m.47652 sp ACHA_DANRE 25.547 274 171 12 70 325 46 304 2.57E-11 68.9 ACHA_DANRE reviewed Acetylcholine receptor subunit alpha chrna1 nic1 Danio rerio (Zebrafish) (Brachydanio rerio) 456 "chondrocyte intercalation involved in growth plate cartilage morphogenesis [GO:0003428]; membrane repolarization [GO:0086009]; motor neuron axon guidance [GO:0008045]; neuromuscular synaptic transmission [GO:0007274]; receptor clustering [GO:0043113]; regulation of axon extension [GO:0030516]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; skeletal muscle fiber development [GO:0048741]; skeletal system morphogenesis [GO:0048705]; synaptic transmission, cholinergic [GO:0007271]" GO:0003428; GO:0004889; GO:0005261; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008045; GO:0030054; GO:0030516; GO:0035094; GO:0043113; GO:0045211; GO:0048705; GO:0048741; GO:0086009 0 0 0 PF02931;PF02932; Q9D4H2 CHOYP_BRAFLDRAFT_96606.1.1 m.8508 sp GCC1_MOUSE 35.828 628 357 8 116 715 164 773 2.57E-96 318 GCC1_MOUSE reviewed GRIP and coiled-coil domain-containing protein 1 (Golgi coiled-coil protein 1) Gcc1 Mus musculus (Mouse) 778 protein targeting to Golgi [GO:0000042] GO:0000042; GO:0000139; GO:0005737; GO:0005794; GO:0005886 0 0 0 PF01465; Q9DC29 CHOYP_ABCB6.2.3 m.11345 sp ABCB6_MOUSE 68.421 209 66 0 1 209 552 760 2.57E-90 286 ABCB6_MOUSE reviewed "ATP-binding cassette sub-family B member 6, mitochondrial" Abcb6 Mus musculus (Mouse) 842 brain development [GO:0007420]; cellular iron ion homeostasis [GO:0006879]; heme transport [GO:0015886]; porphyrin-containing compound biosynthetic process [GO:0006779]; skin development [GO:0043588]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0000139; GO:0005524; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005768; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0006779; GO:0006810; GO:0006879; GO:0007420; GO:0010008; GO:0015439; GO:0015562; GO:0015886; GO:0016021; GO:0020037; GO:0031307; GO:0042626; GO:0043588; GO:0055085; GO:0070062 0 0 0 PF00664;PF00005;PF16185; Q9DFQ7 CHOYP_LOC660560.2.4 m.40915 sp RL24_GILMI 68.354 158 43 2 22 175 1 155 2.57E-68 208 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9GZV8 CHOYP_LOC100373135.1.1 m.9931 sp PRD14_HUMAN 57.596 441 147 8 49 473 152 568 2.57E-171 496 PRD14_HUMAN reviewed PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14) PRDM14 Homo sapiens (Human) 571 "cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; germ cell development [GO:0007281]; germ-line stem cell population maintenance [GO:0030718]; histone H3-R26 methylation [GO:0034972]; homeostasis of number of cells within a tissue [GO:0048873]; inactivation of paternal X chromosome [GO:0060817]; inner cell mass cell fate commitment [GO:0001827]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of DNA methylation [GO:0044030]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000902; GO:0001708; GO:0001827; GO:0003723; GO:0005654; GO:0006351; GO:0007281; GO:0007566; GO:0008168; GO:0009566; GO:0030718; GO:0031490; GO:0034972; GO:0035019; GO:0040037; GO:0044030; GO:0046872; GO:0048873; GO:0060817 0 0 0 PF00096; Q9HBL0 CHOYP_TENS3.4.4 m.60095 sp TENS1_HUMAN 46.175 366 171 5 8 348 6 370 2.57E-107 375 TENS1_HUMAN reviewed Tensin-1 TNS1 TNS Homo sapiens (Human) 1735 cell-substrate junction assembly [GO:0007044]; fibroblast migration [GO:0010761] GO:0005737; GO:0005856; GO:0005925; GO:0007044; GO:0009986; GO:0010761; GO:0044822 0 0 0 PF08416;PF10409;PF00017; Q9NUV9 CHOYP_LOC101164984.2.2 m.65106 sp GIMA4_HUMAN 39.453 256 151 2 15 269 16 268 2.57E-52 180 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9U221 CHOYP_BRAFLDRAFT_287444.3.5 m.17690 sp UNG_CAEEL 59.777 179 69 2 4 181 103 279 2.57E-75 230 UNG_CAEEL reviewed Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung-1 Y56A3A.29 Caenorhabditis elegans 282 base-excision repair [GO:0006284] GO:0004844; GO:0005634; GO:0005739; GO:0006284 0 0 cd10027; PF03167; Q9V5N8 CHOYP_LOC100204612.1.2 m.46968 sp STAN_DROME 28.814 531 309 20 3 492 663 1165 2.57E-31 132 STAN_DROME reviewed Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) 3579 "axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Wnt signaling pathway [GO:0030178]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; positive regulation of Wnt signaling pathway [GO:0030177]; R3/R4 cell fate commitment [GO:0007464]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of establishment of planar polarity [GO:0090175]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" GO:0001736; GO:0001738; GO:0004872; GO:0004888; GO:0004930; GO:0005057; GO:0005509; GO:0005887; GO:0005911; GO:0007156; GO:0007164; GO:0007165; GO:0007367; GO:0007409; GO:0007411; GO:0007464; GO:0016021; GO:0016055; GO:0016318; GO:0016319; GO:0016339; GO:0016358; GO:0019233; GO:0030177; GO:0030178; GO:0035159; GO:0042067; GO:0045746; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:0090175; GO:1902669 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9VCA8 CHOYP_LOC584964.1.1 m.64056 sp ANKHM_DROME 32.208 385 231 11 139 509 588 956 2.57E-45 175 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VD44 CHOYP_MTR_005S0002.1.1 m.13569 sp GLD2A_DROME 42.638 326 177 5 141 458 936 1259 2.57E-78 268 GLD2A_DROME reviewed Poly(A) RNA polymerase gld-2 homolog A (DmGLD2) (EC 2.7.7.19) Gld2 CG5732 Drosophila melanogaster (Fruit fly) 1364 long-term memory [GO:0007616]; mRNA processing [GO:0006397]; RNA polyadenylation [GO:0043631] GO:0003723; GO:0004652; GO:0005524; GO:0005654; GO:0005737; GO:0006397; GO:0007616; GO:0043005; GO:0043631; GO:0046872 0 0 0 PF03828; Q9Y493 CHOYP_NEMVEDRAFT_V1G214844.33.34 m.60752 sp ZAN_HUMAN 35.156 256 165 1 1661 1915 535 790 2.57E-19 100 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A0MGZ7 CHOYP_H6ST2.1.1 m.11151 sp H6ST3_DANRE 56.207 290 124 2 56 344 77 364 2.58E-119 354 H6ST3_DANRE reviewed Heparan-sulfate 6-O-sulfotransferase 3 (HS 6-OST-3) (EC 2.8.2.-) hs6st3 Danio rerio (Zebrafish) (Brachydanio rerio) 419 "heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]" GO:0015015; GO:0016021; GO:0017095 0 0 0 PF03567; D2GXS7 CHOYP_BRAFLDRAFT_241726.3.22 m.3760 sp TRIM2_AILME 24.627 268 164 8 24 268 492 744 2.58E-10 63.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F1R6N4 CHOYP_ECHD1.1.1 m.43890 sp ECHD1_DANRE 43.496 246 134 3 53 294 43 287 2.58E-61 199 ECHD1_DANRE reviewed Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) (EC 4.1.1.41) echdc1 Danio rerio (Zebrafish) (Brachydanio rerio) 302 metabolic process [GO:0008152] GO:0004492; GO:0005829; GO:0008152; GO:0016831 0 0 0 PF00378; O08863 CHOYP_IAP2.5.5 m.66580 sp BIRC3_MOUSE 29.33 358 195 10 584 893 253 600 2.58E-40 161 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; O96064 CHOYP_LOC100373653.2.3 m.43043 sp MYSP_MYTGA 78.992 119 25 0 61 179 395 513 2.58E-40 148 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P04323 CHOYP_LOC580404.1.3 m.7046 sp POL3_DROME 38.869 566 317 11 494 1045 73 623 2.58E-104 354 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P08548 CHOYP_LOC100555596.1.2 m.11498 sp LIN1_NYCCO 30.591 389 258 5 5 387 446 828 2.58E-47 176 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P09481 CHOYP_DWIL_GK15031.1.1 m.56520 sp ACHA3_CHICK 29.773 309 196 11 33 329 28 327 2.58E-24 107 ACHA3_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) 496 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; P17248 CHOYP_SYWC.1.5 m.20736 sp SYWC_BOVIN 73.034 178 48 0 2 179 298 475 2.58E-94 285 SYWC_BOVIN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS Bos taurus (Bovine) 476 regulation of angiogenesis [GO:0045765]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0006436; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P27657 CHOYP_BRAFLDRAFT_224784.1.2 m.20836 sp LIPP_RAT 37.607 234 132 8 102 321 80 313 2.58E-37 142 LIPP_RAT reviewed Pancreatic triacylglycerol lipase (PL) (Pancreatic lipase) (EC 3.1.1.3) Pnlip Rattus norvegicus (Rat) 465 lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; post-embryonic development [GO:0009791]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005615; GO:0006629; GO:0009791; GO:0016042; GO:0016298; GO:0033993; GO:0043434; GO:0046872 0 0 0 PF00151;PF01477; P57088 CHOYP_CDC42.11.11 m.60003 sp TMM33_HUMAN 57.2 250 99 2 18 266 5 247 2.58E-105 308 TMM33_HUMAN reviewed Transmembrane protein 33 (Protein DB83) (SHINC-3) TMEM33 DB83 Homo sapiens (Human) 247 cellular protein localization [GO:0034613]; nuclear pore complex assembly [GO:0051292]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of endoplasmic reticulum tubular network organization [GO:1903371]; response to endoplasmic reticulum stress [GO:0034976] GO:0005635; GO:0005643; GO:0005783; GO:0005789; GO:0017056; GO:0030176; GO:0034613; GO:0034976; GO:0042470; GO:0051292; GO:0070062; GO:1903371; GO:1903896; GO:1903899 0 0 0 PF03661; Q0VFM0 CHOYP_BRAFLDRAFT_114510.1.1 m.52252 sp ZFPL1_XENTR 45.968 372 138 12 1 361 1 320 2.58E-103 310 ZFPL1_XENTR reviewed Zinc finger protein-like 1 zfpl1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 320 vesicle-mediated transport [GO:0016192] GO:0005794; GO:0008270; GO:0016021; GO:0016192 0 0 0 0 Q11118 CHOYP_BRAFLDRAFT_122389.1.1 m.15498 sp WOS2_SCHPO 38.323 167 84 6 36 192 12 169 2.58E-32 118 WOS2_SCHPO reviewed Protein wos2 (p21) wos2 SPAC9E9.13 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 186 cell cycle [GO:0007049] GO:0005634; GO:0005829; GO:0007049 0 0 0 PF04969; Q14162 CHOYP_LOC101068272.1.3 m.40396 sp SREC_HUMAN 38.182 165 80 9 47 194 141 300 2.58E-16 85.1 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q17PI0 CHOYP_EFTS.2.2 m.66393 sp EFTS_AEDAE 43.369 279 146 6 23 293 20 294 2.58E-70 223 EFTS_AEDAE reviewed "Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt)" AAEL000331 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 307 0 GO:0003746; GO:0005739 0 0 0 PF00889; Q19673 CHOYP_CBR-TYR-2.2.2 m.30810 sp TYR3_CAEEL 37.134 307 160 10 336 621 107 401 2.58E-55 207 TYR3_CAEEL reviewed Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans 693 0 GO:0004497; GO:0046872 0 0 0 PF01549;PF00264; Q27J81 CHOYP_INF2.3.5 m.13728 sp INF2_HUMAN 40.333 300 175 4 13 311 27 323 2.58E-53 207 INF2_HUMAN reviewed Inverted formin-2 (HBEBP2-binding protein C) INF2 C14orf151 C14orf173 Homo sapiens (Human) 1249 actin cytoskeleton organization [GO:0030036]; regulation of mitochondrial fission [GO:0090140] GO:0030036; GO:0048471; GO:0090140 0 0 0 PF06367;PF06371;PF02181;PF02205; Q4UMH6 CHOYP_TVAG_291510.3.9 m.18911 sp Y381_RICFE 22.481 516 343 16 11 505 673 1152 2.58E-14 80.5 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q53G44 CHOYP_LOC100377780.5.11 m.46180 sp IF44L_HUMAN 31.532 444 264 6 25 462 26 435 2.58E-54 191 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5RD69 CHOYP_AGAP_AGAP005942.3.3 m.27180 sp TICN3_PONAB 32.432 111 55 3 58 160 277 375 2.58E-09 60.1 TICN3_PONAB reviewed "Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)" SPOCK3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 436 signal transduction [GO:0007165] GO:0005509; GO:0005578; GO:0007165; GO:0008191 0 0 0 PF07648;PF10591;PF00086; Q5VYX0 CHOYP_BRAFLDRAFT_72357.1.1 m.59063 sp RNLS_HUMAN 46.334 341 179 3 6 345 1 338 2.58E-101 305 RNLS_HUMAN reviewed Renalase (EC 1.6.3.5) (Monoamine oxidase-C) (MAO-C) RNLS C10orf59 Homo sapiens (Human) 342 response to epinephrine [GO:0071871]; response to ischemia [GO:0002931]; response to salt [GO:1902074] GO:0002931; GO:0005615; GO:0016491; GO:0071871; GO:1902074 0 0 0 PF01593; Q5YCC5 CHOYP_LOC100183991.1.1 m.6326 sp TMC7_CHICK 36.115 659 391 9 56 705 89 726 2.58E-133 416 TMC7_CHICK reviewed Transmembrane channel-like protein 7 Tmc7 Gallus gallus (Chicken) 735 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q6DFV8 CHOYP_BRAFLDRAFT_80496.9.10 m.58668 sp VWDE_MOUSE 24.495 396 255 17 481 863 267 631 2.58E-17 91.7 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6DIR8 CHOYP_LOC100563071.1.1 m.18160 sp PALD_XENTR 37.167 826 501 10 41 859 57 871 2.58E-178 539 PALD_XENTR reviewed Paladin pald1 pald TGas002h03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 872 0 GO:0004725; GO:0005634; GO:0005737; GO:0005829 0 0 0 0 Q6P0D0 CHOYP_QKIA.1.1 m.8934 sp QKIA_DANRE 76.596 47 10 1 1 46 167 213 2.58E-15 72.8 QKIA_DANRE reviewed Protein quaking-A (zqk) qkia qk Danio rerio (Zebrafish) (Brachydanio rerio) 341 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; regulation of smoothened signaling pathway [GO:0008589]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]; skeletal muscle tissue development [GO:0007519] GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0006417; GO:0007519; GO:0008380; GO:0008589; GO:0030154; GO:0051028; GO:0070935 0 0 0 PF00013;PF16551;PF16544; Q6RUV5 CHOYP_RAC1.1.3 m.20871 sp RAC1_RAT 89.583 192 19 1 1 191 1 192 2.58E-128 361 RAC1_RAT reviewed Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) 192 "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure arrangement [GO:0048532]; auditory receptor cell morphogenesis [GO:0002093]; axon guidance [GO:0007411]; bone resorption [GO:0045453]; cell-cell junction organization [GO:0045216]; cell motility [GO:0048870]; cell proliferation [GO:0008283]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex GABAergic interneuron development [GO:0021894]; cerebral cortex radially oriented cell migration [GO:0021799]; chemotaxis [GO:0006935]; cochlea morphogenesis [GO:0090103]; dendrite morphogenesis [GO:0048813]; dopaminergic neuron differentiation [GO:0071542]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; engulfment of apoptotic cell [GO:0043652]; epithelial cell morphogenesis [GO:0003382]; G-protein coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; hyperosmotic response [GO:0006972]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; mast cell chemotaxis [GO:0002551]; negative regulation of interleukin-23 production [GO:0032707]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of DNA replication [GO:0045740]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane [GO:0072659]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; regulation of cell size [GO:0008361]; regulation of fibroblast migration [GO:0010762]; regulation of neuron maturation [GO:0014041]; regulation of respiratory burst [GO:0060263]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000139; GO:0001891; GO:0001934; GO:0002093; GO:0002551; GO:0003382; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005802; GO:0005829; GO:0005884; GO:0005925; GO:0006935; GO:0006972; GO:0007015; GO:0007186; GO:0007411; GO:0008283; GO:0008361; GO:0010592; GO:0010762; GO:0014041; GO:0016020; GO:0016601; GO:0017137; GO:0019897; GO:0019901; GO:0021799; GO:0021831; GO:0021894; GO:0030027; GO:0030032; GO:0030036; GO:0030041; GO:0030334; GO:0030838; GO:0031410; GO:0031901; GO:0032587; GO:0032707; GO:0034446; GO:0036464; GO:0042470; GO:0042826; GO:0043552; GO:0043652; GO:0045216; GO:0045453; GO:0045740; GO:0048532; GO:0048813; GO:0048870; GO:0048873; GO:0051022; GO:0051496; GO:0051668; GO:0051894; GO:0051932; GO:0060071; GO:0060263; GO:0070062; GO:0071260; GO:0071526; GO:0071542; GO:0072659; GO:0090023; GO:0090103; GO:0097178; GO:1900026 0 0 0 PF00071; Q6XKE6 CHOYP_LOC100486317.4.5 m.54767 sp POLG_PVCV2 22.432 370 258 10 190 554 1460 1805 2.58E-10 67.4 POLG_PVCV2 reviewed Genome polyprotein [Cleaved into: Movement protein (MP); Capsid protein (CP); Aspartic protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49)] 0 Petunia vein clearing virus (isolate Hohn) (PVCV) 2180 "transport of virus in host, cell to cell [GO:0046740]" GO:0003677; GO:0003964; GO:0004190; GO:0004519; GO:0008270; GO:0046740 0 0 0 PF01107;PF00078;PF00098; Q70FJ1 CHOYP_TVAG_193760.2.4 m.32882 sp AKAP9_MOUSE 34.286 455 283 7 1478 1930 1678 2118 2.58E-45 186 AKAP9_MOUSE reviewed A-kinase anchor protein 9 (AKAP-9) (Protein kinase A-anchoring protein 9) (PRKA9) Akap9 Kiaa0803 Mus musculus (Mouse) 3797 microtubule nucleation [GO:0007020]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] GO:0000242; GO:0005737; GO:0005794; GO:0005795; GO:0005813; GO:0007020; GO:0007165; GO:0007283; GO:0036064; GO:0060009 0 0 0 PF10495; Q8IVG5 CHOYP_LOC100368251.2.6 m.34415 sp SAM9L_HUMAN 25.477 1519 932 61 779 2199 164 1580 2.58E-87 321 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8NFD2 CHOYP_LOC756750.1.1 m.21064 sp ANKK1_HUMAN 38.158 152 93 1 806 956 369 520 2.58E-21 103 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8WXB1 CHOYP_MT21A.1.1 m.15450 sp MT21A_HUMAN 50.467 214 104 2 65 276 1 214 2.58E-71 221 MT21A_HUMAN reviewed Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A) METTL21A FAM119A HCA557B Homo sapiens (Human) 218 peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479] GO:0005737; GO:0006479; GO:0016279; GO:0018022; GO:0030544; GO:0051117 0 0 0 PF10294; Q8WZ42 CHOYP_TTN.1.9 m.6052 sp TITIN_HUMAN 32.624 141 94 1 84 224 1439 1578 2.58E-15 82 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q91312 CHOYP_TSP_11071.1.1 m.15125 sp CRYAB_LITCT 31.875 160 98 5 44 194 8 165 2.58E-17 78.6 CRYAB_LITCT reviewed Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 173 0 GO:0005212; GO:0042803; GO:0046872 0 0 0 PF00525;PF00011; Q9ESN6 CHOYP_TRIM2.17.59 m.32440 sp TRIM2_MOUSE 29.508 183 105 9 76 249 536 703 2.58E-07 54.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NU22 CHOYP_MDN1.5.8 m.7465 sp MDN1_HUMAN 42.5 400 206 4 1 396 2036 2415 2.58E-88 300 MDN1_HUMAN reviewed Midasin (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) 5596 protein complex assembly [GO:0006461]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0006461; GO:0016020; GO:0016887; GO:0045111; GO:0051082 0 0 0 PF07728; Q9UKK9 CHOYP_LOC100691676.1.1 m.64226 sp NUDT5_HUMAN 51.777 197 93 2 2 196 9 205 2.58E-71 218 NUDT5_HUMAN reviewed ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.-) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H) NUDT5 NUDIX5 HSPC115 Homo sapiens (Human) 219 ATP generation from poly-ADP-D-ribose [GO:1990966]; chromatin remodeling [GO:0006338]; D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule catabolic process [GO:0034656]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191] GO:0000287; GO:0005622; GO:0005634; GO:0005829; GO:0006338; GO:0009117; GO:0009191; GO:0016779; GO:0019144; GO:0019303; GO:0030515; GO:0034656; GO:0042803; GO:0044715; GO:0047631; GO:0070062; GO:1990966 0 0 0 PF00293; Q9ULT8 CHOYP_BRAFLDRAFT_120990.18.18 m.61785 sp HECD1_HUMAN 57.895 57 21 2 646 700 1277 1332 2.58E-10 68.9 HECD1_HUMAN reviewed E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1) HECTD1 KIAA1131 Homo sapiens (Human) 2610 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005737; GO:0016874; GO:0042787; GO:0046872 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF00632;PF06701;PF07738; Q9VUI3 CHOYP_LOC100366749.1.1 m.7586 sp EMAL_DROME 31.05 219 136 9 73 287 167 374 2.58E-14 79.7 EMAL_DROME reviewed Echinoderm microtubule-associated protein-like CG42247 DCX-EMAP CG42247 Drosophila melanogaster (Fruit fly) 1076 adult locomotory behavior [GO:0008344]; intracellular signal transduction [GO:0035556]; melanotic encapsulation of foreign target [GO:0035011]; sensory perception of sound [GO:0007605] GO:0005737; GO:0005874; GO:0007605; GO:0008017; GO:0008344; GO:0035011; GO:0035556; GO:0071683 0 0 cd01617; PF03607;PF03451;PF00400; A2AX52 CHOYP_BRAFLDRAFT_90332.4.4 m.26637 sp CO6A4_MOUSE 22.9 869 557 24 6 834 409 1204 2.59E-41 172 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A5YM72 CHOYP_LOC100733118.1.1 m.46191 sp CRNS1_HUMAN 33.094 837 523 13 128 937 1 827 2.59E-144 452 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A7M7B9 CHOYP_LOC763904.2.2 m.30733 sp NTH_CHICK 62.249 249 85 2 73 319 38 279 2.59E-112 330 NTH_CHICK reviewed Endonuclease III-like protein 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycoslyase/AP lyase) NTHL1 Gallus gallus (Chicken) 281 "base-excision repair, AP site formation [GO:0006285]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792]" GO:0000703; GO:0002230; GO:0003690; GO:0005634; GO:0005739; GO:0006285; GO:0006296; GO:0046872; GO:0051539; GO:0098779; GO:0098792 0 0 cd00056; PF00633;PF00730; O01761 CHOYP_OBSCN.2.2 m.40322 sp UNC89_CAEEL 34.409 93 59 2 41 132 5593 5684 2.59E-11 69.3 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O70277 CHOYP_LOC100369333.7.32 m.27898 sp TRIM3_RAT 33.962 106 66 3 43 145 627 731 2.59E-10 60.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_110072.2.8 m.3556 sp TRIM3_HUMAN 24.314 255 152 12 288 518 469 706 2.59E-08 60.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88799 CHOYP_LOC100640167.1.1 m.43324 sp ZAN_MOUSE 29.707 478 284 16 1395 1830 543 1010 2.59E-09 67 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; P02552 CHOYP_BRAFLDRAFT_58035.2.2 m.65815 sp TBA1_CHICK 91.346 104 9 0 1 104 162 265 2.59E-60 194 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P0CB05 CHOYP_CEP63.2.2 m.35715 sp CEP63_CHICK 30.83 759 450 17 145 882 4 708 2.59E-79 275 CEP63_CHICK reviewed Centrosomal protein of 63 kDa (Cep63) CEP63 Gallus gallus (Chicken) 711 cell division [GO:0051301]; centriole replication [GO:0007099]; de novo centriole assembly [GO:0098535]; DNA damage checkpoint [GO:0000077]; mitotic nuclear division [GO:0007067]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225] GO:0000077; GO:0000922; GO:0005813; GO:0005814; GO:0007067; GO:0007099; GO:0042770; GO:0051225; GO:0051301; GO:0098535 0 0 0 PF17045; P10079 CHOYP_LOC575027.3.6 m.37536 sp FBP1_STRPU 54.148 229 103 2 110 338 330 556 2.59E-68 246 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P16157 CHOYP_LOC753709.32.44 m.58258 sp ANK1_HUMAN 28.974 780 459 26 29 753 47 786 2.59E-57 217 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_LOC753709.33.44 m.59575 sp ANK1_HUMAN 30.168 716 473 24 12 706 77 786 2.59E-59 221 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P21912 CHOYP_DHSB.1.1 m.3993 sp SDHB_HUMAN 77.395 261 54 2 29 289 23 278 2.59E-152 430 SDHB_HUMAN reviewed "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)" SDHB SDH SDH1 Homo sapiens (Human) 280 aerobic respiration [GO:0009060]; respiratory electron transport chain [GO:0022904]; succinate metabolic process [GO:0006105]; tricarboxylic acid cycle [GO:0006099] GO:0005654; GO:0005739; GO:0005743; GO:0005749; GO:0005886; GO:0006099; GO:0006105; GO:0008177; GO:0009055; GO:0009060; GO:0022904; GO:0046872; GO:0048039; GO:0051537; GO:0051538; GO:0051539; GO:0070062 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. 0 cd00207; PF13085; P62919 CHOYP_RL8.2.10 m.14506 sp RL8_RAT 81.013 158 30 0 1 158 1 158 2.59E-92 272 RL8_RAT reviewed 60S ribosomal protein L8 Rpl8 Rattus norvegicus (Rat) 257 cellular response to nerve growth factor stimulus [GO:1990090]; cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0022625; GO:1990090; GO:1990932 0 0 0 PF00181;PF03947; P90689 CHOYP_ACTC.3.6 m.21573 sp ACT_BRUMA 93.651 63 4 0 1 63 1 63 2.59E-36 129 ACT_BRUMA reviewed Actin 0 Brugia malayi (Filarial nematode worm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P97478 CHOYP_LOC100377736.1.1 m.251 sp COQ7_MOUSE 65.909 176 60 0 20 195 42 217 2.59E-84 251 COQ7_MOUSE reviewed "5-demethoxyubiquinone hydroxylase, mitochondrial (DMQ hydroxylase) (EC 1.14.13.-) (Timing protein clk-1 homolog) (Ubiquinone biosynthesis monooxygenase COQ7)" Coq7 Mus musculus (Mouse) 217 age-dependent response to oxidative stress [GO:0001306]; cellular response to oxidative stress [GO:0034599]; determination of adult lifespan [GO:0008340]; in utero embryonic development [GO:0001701]; mitochondrial ATP synthesis coupled electron transport [GO:0042775]; mitochondrion morphogenesis [GO:0070584]; neural tube formation [GO:0001841]; neurogenesis [GO:0022008]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979]; ubiquinone biosynthetic process [GO:0006744] GO:0001306; GO:0001701; GO:0001841; GO:0005634; GO:0005739; GO:0006744; GO:0006979; GO:0008340; GO:0016709; GO:0022008; GO:0022904; GO:0031314; GO:0034599; GO:0042775; GO:0046872; GO:0070584 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03194}. 0 cd01042; PF03232; Q01484 CHOYP_LOC583072.18.25 m.54526 sp ANK2_HUMAN 32.006 703 407 4 160 791 83 785 2.59E-103 354 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q14919 CHOYP_NC2A.1.1 m.22786 sp NC2A_HUMAN 54.14 157 68 1 16 168 1 157 2.59E-48 164 NC2A_HUMAN reviewed Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) DRAP1 Homo sapiens (Human) 205 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003700; GO:0003714; GO:0005634; GO:0006351; GO:0042802 0 0 0 PF00808; Q25379 CHOYP_A1.1.1 m.38446 sp ACT3_LYTPI 89.231 65 7 0 1 65 24 88 2.59E-35 122 ACT3_LYTPI reviewed "Actin, cytoskeletal 3 (LPC3) (Fragment)" 0 Lytechinus pictus (Painted sea urchin) 172 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q32M45 CHOYP_DYAK_GE25120.2.2 m.25181 sp ANO4_HUMAN 33.232 328 182 13 18 329 43 349 2.59E-42 159 ANO4_HUMAN reviewed Anoctamin-4 (Transmembrane protein 16D) ANO4 TMEM16D Homo sapiens (Human) 955 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transport [GO:0006821]; ion transmembrane transport [GO:0034220] GO:0005229; GO:0005622; GO:0005886; GO:0006821; GO:0016021; GO:0017128; GO:0034220; GO:0061589; GO:0061590; GO:0061591 0 0 0 PF16178;PF04547; Q4PM12 CHOYP_RL36.2.8 m.12256 sp RL36_IXOSC 58.095 105 42 1 1 105 1 103 2.59E-39 130 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q6DFF6 CHOYP_KLH20.1.2 m.42996 sp KLH20_XENLA 29.967 614 364 12 9 615 1 555 2.59E-72 248 KLH20_XENLA reviewed Kelch-like protein 20 klhl20 Xenopus laevis (African clawed frog) 604 Golgi to endosome transport [GO:0006895]; negative regulation of apoptotic process [GO:0043066]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K33-linked ubiquitination [GO:1990390]; protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005802; GO:0005829; GO:0006895; GO:0015031; GO:0016567; GO:0016605; GO:0019964; GO:0031463; GO:0043066; GO:0043161; GO:0048471; GO:1990390 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6DIB5 CHOYP_LOC100543109.1.1 m.45120 sp MEG10_MOUSE 39.024 246 130 13 170 414 344 570 2.59E-27 120 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q7W977 CHOYP_BRAFLDRAFT_84643.1.1 m.40975 sp ECTD_BORPA 23.043 230 159 6 4 218 28 254 2.59E-10 63.2 ECTD_BORPA reviewed Ectoine dioxygenase (EC 1.14.11.-) (Ectoine hydroxylase) ectD BPP1891 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 308 ectoine catabolic process [GO:0042400] GO:0005506; GO:0016706; GO:0042400 0 0 0 PF05721; Q7Z3F1 CHOYP_LOC661299.1.1 m.51706 sp GP155_HUMAN 35.621 918 488 19 4 915 29 849 2.59E-169 518 GP155_HUMAN reviewed Integral membrane protein GPR155 (G-protein coupled receptor PGR22) GPR155 PGR22 Homo sapiens (Human) 870 cognition [GO:0050890]; intracellular signal transduction [GO:0035556]; transmembrane transport [GO:0055085] GO:0005622; GO:0016021; GO:0035556; GO:0050890; GO:0055085; GO:0070062 0 0 0 PF00610;PF03547; Q895K2 CHOYP_LOC100377759.1.15 m.47 sp DPO3_CLOTE 28.902 173 96 9 65 233 398 547 2.59E-06 53.1 DPO3_CLOTE reviewed DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC CTC_01271 Clostridium tetani (strain Massachusetts / E88) 1427 DNA-dependent DNA replication [GO:0006261] GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 0 0 0 PF11490;PF07733;PF14579;PF02811;PF00929;PF01336; Q8AYS7 CHOYP_LOC576953.1.1 m.7037 sp CENPI_CHICK 31.497 708 447 13 5 696 52 737 2.59E-107 346 CENPI_CHICK reviewed Centromere protein I (CENP-I) CENPI Gallus gallus (Chicken) 753 centromere complex assembly [GO:0034508] GO:0000776; GO:0005634; GO:0005737; GO:0034508 0 0 0 PF07778; Q8CHP8 CHOYP_LOC100375890.1.1 m.10490 sp PGP_MOUSE 38.486 317 173 5 13 315 7 315 2.59E-71 227 PGP_MOUSE reviewed Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) Pgp Mus musculus (Mouse) 321 dephosphorylation [GO:0016311]; glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721]; peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0000121; GO:0000287; GO:0004725; GO:0005829; GO:0006114; GO:0006650; GO:0008967; GO:0016311; GO:0035335; GO:0043136; GO:0045721; GO:0098519 0 0 0 PF13344; Q8IW45 CHOYP_PC11X.1.2 m.24796 sp NNRD_HUMAN 56.229 297 125 1 40 336 54 345 2.59E-117 345 NNRD_HUMAN reviewed ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) NAXD CARKD Homo sapiens (Human) 347 nicotinamide metabolic process [GO:0006769]; nicotinamide nucleotide metabolic process [GO:0046496] GO:0005524; GO:0005759; GO:0006769; GO:0046496; GO:0047453; GO:0052855 0 0 cd01171; PF01256; Q8K3K9 CHOYP_GIMA4.4.7 m.42250 sp GIMA4_RAT 31.179 263 150 10 21 274 1 241 2.59E-26 108 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8TCB0 CHOYP_LOC100377780.10.11 m.57495 sp IFI44_HUMAN 33.793 145 96 0 4 148 279 423 2.59E-19 86.7 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q92538 CHOYP_GBF1.1.1 m.22858 sp GBF1_HUMAN 62.5 112 36 3 7 112 1607 1718 2.59E-34 134 GBF1_HUMAN reviewed Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1) GBF1 KIAA0248 Homo sapiens (Human) 1859 "cell activation involved in immune response [GO:0002263]; COPI coating of Golgi vesicle [GO:0048205]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of monopolar cell polarity [GO:0061162]; Golgi disassembly [GO:0090166]; Golgi organization [GO:0007030]; Golgi to endosome transport [GO:0006895]; neutrophil chemotaxis [GO:0030593]; post-Golgi vesicle-mediated transport [GO:0006892]; protein localization to endoplasmic reticulum exit site [GO:0070973]; protein localization to endoplasmic reticulum tubular network [GO:1903420]; protein localization to Golgi apparatus [GO:0034067]; protein transport [GO:0015031]; reactive oxygen species biosynthetic process [GO:1903409]; regulation of ARF protein signal transduction [GO:0032012]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; viral process [GO:0016032]" GO:0000139; GO:0002263; GO:0005085; GO:0005086; GO:0005547; GO:0005739; GO:0005777; GO:0005788; GO:0005793; GO:0005794; GO:0005795; GO:0005801; GO:0005802; GO:0005811; GO:0005829; GO:0006888; GO:0006890; GO:0006892; GO:0006895; GO:0007030; GO:0007346; GO:0015031; GO:0016020; GO:0016032; GO:0030593; GO:0031252; GO:0032012; GO:0034067; GO:0042147; GO:0048205; GO:0061162; GO:0070973; GO:0080025; GO:0090166; GO:0097111; GO:1903409; GO:1903420; GO:2000008 0 0 0 PF01369;PF12783; Q95J53 CHOYP_LOC100370504.1.2 m.17506 sp BTBDG_MACFA 32.823 588 289 10 76 661 4 487 2.59E-95 306 BTBDG_MACFA reviewed BTB/POZ domain-containing protein 16 BTBD16 QnpA-11731 QtsA-17449 QtsA-17837 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 504 0 0 0 0 0 0 Q99575 CHOYP_LOC100369630.1.1 m.38718 sp POP1_HUMAN 34.84 686 375 15 52 708 70 712 2.59E-116 383 POP1_HUMAN reviewed Ribonucleases P/MRP protein subunit POP1 (hPOP1) (EC 3.1.26.5) POP1 KIAA0061 Homo sapiens (Human) 1024 tRNA 5'-leader removal [GO:0001682]; tRNA catabolic process [GO:0016078]; tRNA processing [GO:0008033] GO:0000171; GO:0000172; GO:0001682; GO:0004526; GO:0005615; GO:0005654; GO:0005655; GO:0008033; GO:0016078; GO:0044822 0 0 0 PF06978;PF08170; Q9BY27 CHOYP_DGC6L.1.1 m.47994 sp DGC6L_HUMAN 50 180 88 1 36 215 9 186 2.59E-47 158 DGC6L_HUMAN reviewed Protein DGCR6L (DiGeorge syndrome critical region 6-like protein) DGCR6L Homo sapiens (Human) 220 0 GO:0005634 0 0 0 PF07324; Q9Y6R7 CHOYP_LOC580187.3.4 m.42474 sp FCGBP_HUMAN 23.515 404 272 12 166 551 36 420 2.59E-17 90.1 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; C7G0B5 CHOYP_PIF.3.6 m.18904 sp PIF_PINFU 32.576 264 137 7 69 298 255 511 2.60E-30 127 PIF_PINFU reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 1007 chitin metabolic process [GO:0006030] GO:0005578; GO:0006030; GO:0008061 0 0 0 PF00092; D2GXS7 CHOYP_BRAFLDRAFT_89819.1.4 m.3221 sp TRIM2_AILME 36.585 82 50 2 38 118 623 703 2.60E-07 50.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_LOC100373444.36.79 m.33465 sp TRIM2_AILME 25.591 254 162 7 309 552 506 742 2.60E-13 76.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14522 CHOYP_PTPRA.4.22 m.15973 sp PTPRT_HUMAN 32.422 512 325 8 6 500 924 1431 2.60E-72 253 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O15990 CHOYP_KARG.8.11 m.45500 sp KARG_LIOJA 63.871 155 55 1 26 179 1 155 2.60E-64 204 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O75382 CHOYP_BRAFLDRAFT_205965.43.43 m.66336 sp TRIM3_HUMAN 26.974 152 101 7 36 182 597 743 2.60E-06 52.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P07314 CHOYP_LOC580355.1.1 m.29389 sp GGT1_RAT 37.75 551 317 16 73 613 27 561 2.60E-109 343 GGT1_RAT reviewed Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] Ggt1 Ggt Rattus norvegicus (Rat) 568 aging [GO:0007568]; cellular response to oxidative stress [GO:0034599]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; peptide modification [GO:0031179]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; zymogen activation [GO:0031638] GO:0003840; GO:0005615; GO:0005886; GO:0005887; GO:0006536; GO:0006750; GO:0006751; GO:0007568; GO:0031179; GO:0031638; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374 PATHWAY: Sulfur metabolism; glutathione metabolism. 0 0 PF01019; P12812 CHOYP_HSP21.4.1.1 m.8171 sp P40_SCHMA 27.647 170 97 2 87 230 64 233 2.60E-13 74.3 P40_SCHMA reviewed Major egg antigen (p40) 0 Schistosoma mansoni (Blood fluke) 354 0 0 0 0 0 PF00011; P20825 CHOYP_LOC100695950.6.6 m.35321 sp POL2_DROME 37.698 504 291 7 48 545 141 627 2.60E-97 323 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P55202 CHOYP_TRIADDRAFT_30655.1.1 m.7975 sp ANPRB_ANGJA 34.816 1034 581 23 88 1103 84 1042 2.60E-179 567 ANPRB_ANGJA reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) npr2 Anguilla japonica (Japanese eel) 1050 intracellular signal transduction [GO:0035556]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005622; GO:0005886; GO:0005887; GO:0007168; GO:0016941; GO:0035556 0 0 0 PF01094;PF00211;PF07714; P86788 CHOYP_GIGA5.3.4 m.17227 sp GIGA5_CRAGI 93.333 75 4 1 246 320 40 113 2.60E-42 145 GIGA5_CRAGI reviewed Gigasin-5 (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 113 0 0 0 0 0 0 Q10725 CHOYP_LOC101158498.1.1 m.56779 sp FSDH_RALPI 32 275 179 6 6 278 5 273 2.60E-37 137 FSDH_RALPI reviewed Phenylserine dehydratase (EC 4.2.1.-) psdht Ralstonia pickettii (Burkholderia pickettii) 326 0 GO:0016829 0 0 0 PF00291; Q20758 CHOYP_BRAFLDRAFT_86801.1.1 m.27108 sp ARL1_CAEEL 75.556 180 44 0 1 180 1 180 2.60E-99 287 ARL1_CAEEL reviewed ADP-ribosylation factor-like protein 1 arl-1 F54C9.10 Caenorhabditis elegans 180 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q283Q6 CHOYP_BRAFLDRAFT_126369.1.1 m.7981 sp DBF4B_XENLA 26.937 271 182 5 10 266 24 292 2.60E-22 105 DBF4B_XENLA reviewed Protein DBF4 homolog B (Dbf4-related factor 1) (XDrf1) dbf4b drf1 Xenopus laevis (African clawed frog) 784 cell cycle [GO:0007049]; multicellular organism development [GO:0007275] GO:0003676; GO:0005634; GO:0007049; GO:0007275; GO:0008270 0 0 0 PF07535; Q2TAK8 CHOYP_SALIVA_1456.1.1 m.19330 sp MUM1_HUMAN 26.582 316 197 15 824 1130 414 703 2.60E-09 65.1 MUM1_HUMAN reviewed PWWP domain-containing protein MUM1 (Mutated melanoma-associated antigen 1) (MUM-1) (Protein expandere) MUM1 EXPAND1 Homo sapiens (Human) 710 chromatin organization [GO:0006325]; DNA repair [GO:0006281] GO:0005634; GO:0005737; GO:0006281; GO:0006325; GO:0031491 0 0 0 0 Q55CD9 CHOYP_LOC100634472.2.3 m.17596 sp NDH_DICDI 42.548 416 225 6 29 434 40 451 2.60E-106 325 NDH_DICDI reviewed Probable NADH dehydrogenase (EC 1.6.-.-) DDB_G0270104 Dictyostelium discoideum (Slime mold) 451 0 GO:0016491 0 0 0 PF07992; Q5BK68 CHOYP_SNPC3.1.1 m.7230 sp SNPC3_RAT 41.964 336 179 6 45 378 81 402 2.60E-83 262 SNPC3_RAT reviewed snRNA-activating protein complex subunit 3 (SNAPc subunit 3) (Small nuclear RNA-activating complex polypeptide 3) Snapc3 Rattus norvegicus (Rat) 407 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF12251; Q5JVG2 CHOYP_ZN891.1.1 m.17485 sp ZN484_HUMAN 28.505 214 121 11 366 568 608 800 2.60E-10 67 ZN484_HUMAN reviewed Zinc finger protein 484 ZNF484 Homo sapiens (Human) 852 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q5K651 CHOYP_SAM9L.1.2 m.51914 sp SAMD9_HUMAN 31.818 198 105 6 64 258 182 352 2.60E-17 90.1 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q5R8L2 CHOYP_PSC.1.1 m.7576 sp BMI1_PONAB 56.485 239 91 5 1 238 1 227 2.60E-80 266 BMI1_PONAB reviewed Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) BMI1 PCGF4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 326 "brain development [GO:0007420]; DNA methylation [GO:0006306]; embryonic skeletal system morphogenesis [GO:0048704]; histone acetylation [GO:0016573]; histone ubiquitination [GO:0016574]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; rostrocaudal neural tube patterning [GO:0021903]; somatic stem cell division [GO:0048103]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000151; GO:0000792; GO:0001701; GO:0005737; GO:0006306; GO:0006351; GO:0006959; GO:0007420; GO:0008270; GO:0016573; GO:0016574; GO:0016604; GO:0021903; GO:0030890; GO:0031519; GO:0033092; GO:0043565; GO:0045814; GO:0048103; GO:0048704; GO:0051443; GO:0097027; GO:1990841; GO:2001234 0 0 0 PF16207; Q5RBQ7 CHOYP_CDO1.2.4 m.35631 sp CDO1_PONAB 44.828 174 90 1 39 212 29 196 2.60E-46 154 CDO1_PONAB reviewed Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) CDO1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 200 taurine biosynthetic process [GO:0042412] GO:0005506; GO:0005829; GO:0017172; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. 0 0 PF05995; Q5T6F2 CHOYP_BRAFLDRAFT_125234.2.2 m.19033 sp UBAP2_HUMAN 40.613 261 98 18 1034 1260 792 1029 2.60E-23 112 UBAP2_HUMAN reviewed Ubiquitin-associated protein 2 (UBAP-2) UBAP2 KIAA1491 Homo sapiens (Human) 1119 0 GO:0005913; GO:0044822; GO:0098641 0 0 0 PF12478; Q5ZJI9 CHOYP_UBAC1.1.1 m.51119 sp UBAC1_CHICK 43.237 414 207 7 39 435 1 403 2.60E-106 323 UBAC1_CHICK reviewed Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (E3 ubiquitin-protein ligase subunit KPC2) (Kip1 ubiquitination-promoting complex protein 2) UBAC1 KPC2 UBADC1 RCJMB04_17l24 Gallus gallus (Chicken) 408 protein ubiquitination [GO:0016567] GO:0005737; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00627; Q7YT83 CHOYP_LOC764722.1.3 m.16471 sp TX31_CONTE 38.38 284 142 10 122 386 27 296 2.60E-49 175 TX31_CONTE reviewed Cysteine-rich venom protein (CRVP) (EC 3.4.-.-) (Substrate-specific endoprotease Tex31) 0 Conus textile (Cloth-of-gold cone) 300 0 GO:0005576; GO:0008233 0 0 0 PF00188; Q8BTY2 CHOYP_DWIL_GK24730.1.1 m.50460 sp S4A7_MOUSE 35.821 201 119 7 33 227 88 284 2.60E-27 113 S4A7_MOUSE reviewed Sodium bicarbonate cotransporter 3 (Solute carrier family 4 member 7) Slc4a7 Nbc3 Mus musculus (Mouse) 1034 anion transmembrane transport [GO:0098656]; auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; camera-type eye photoreceptor cell differentiation [GO:0060219]; cochlear nucleus development [GO:0021747]; regulation of intracellular pH [GO:0051453]; retinal cell programmed cell death [GO:0046666]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; sodium ion transport [GO:0006814]; visual perception [GO:0007601] GO:0005452; GO:0005737; GO:0005886; GO:0005887; GO:0006814; GO:0007601; GO:0008509; GO:0015293; GO:0015701; GO:0016323; GO:0016324; GO:0021747; GO:0032420; GO:0046666; GO:0051453; GO:0060117; GO:0060219; GO:0061299; GO:0098656 0 0 0 PF07565;PF00955; Q921X9 CHOYP_LOC100372340.3.3 m.59986 sp PDIA5_MOUSE 39.645 338 182 10 15 346 180 501 2.60E-63 213 PDIA5_MOUSE reviewed Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) Pdia5 Pdir Mus musculus (Mouse) 517 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005783; GO:0005788; GO:0006457; GO:0034976; GO:0045454 0 0 0 PF00085; Q924H0 CHOYP_LOC100167869.1.1 m.8286 sp NPFF2_MOUSE 27.442 215 138 7 53 254 62 271 2.60E-10 65.5 NPFF2_MOUSE reviewed Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor) Npffr2 Gpr74 Npff2 Mus musculus (Mouse) 417 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; G-protein coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase activity [GO:0045761]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of MAPK cascade [GO:0043408]; response to peptide [GO:1901652] GO:0005886; GO:0005887; GO:0007186; GO:0007268; GO:0008188; GO:0015629; GO:0032870; GO:0042277; GO:0043408; GO:0045761; GO:1901652; GO:2000479 0 0 0 PF00001; Q96DM1 CHOYP_LOC100661020.2.5 m.23367 sp PGBD4_HUMAN 28.215 521 313 14 83 565 87 584 2.60E-58 207 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q96PE2 CHOYP_LOC540026.1.1 m.37906 sp ARHGH_HUMAN 37.647 170 103 2 28 195 1065 1233 2.60E-35 134 ARHGH_HUMAN reviewed Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) ARHGEF17 KIAA0337 TEM4 Homo sapiens (Human) 2063 actin cytoskeleton organization [GO:0030036]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005085; GO:0005089; GO:0005829; GO:0030036; GO:0035023; GO:0043065; GO:0051056 0 0 0 PF00621; Q96RW7 CHOYP_BRAFLDRAFT_236936.3.6 m.29228 sp HMCN1_HUMAN 47.719 285 148 1 63 346 4585 4869 2.60E-78 266 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BQC6 CHOYP_MRP63.1.1 m.28271 sp RT63_HUMAN 35.417 96 59 2 25 120 9 101 2.60E-07 48.5 RT63_HUMAN reviewed "Ribosomal protein 63, mitochondrial (hMRP63) (Mitochondrial ribosomal protein 63) (Mitochondrial ribosomal protein L57)" MRPL57 MRP63 Homo sapiens (Human) 102 mitochondrial translation [GO:0032543] GO:0003735; GO:0005761; GO:0032543 0 0 0 PF14978; Q9D882 CHOYP_RS3A.2.15 m.2684 sp CJ035_MOUSE 37 100 44 3 1 90 1 91 2.60E-11 59.7 CJ035_MOUSE reviewed Uncharacterized protein C10orf35 homolog 0 Mus musculus (Mouse) 120 0 GO:0016021 0 0 0 PF15378; Q9D882 CHOYP_RS3A.3.15 m.3698 sp CJ035_MOUSE 37 100 44 3 1 90 1 91 2.60E-11 59.7 CJ035_MOUSE reviewed Uncharacterized protein C10orf35 homolog 0 Mus musculus (Mouse) 120 0 GO:0016021 0 0 0 PF15378; Q9NSN8 CHOYP_LOC659142.1.1 m.38860 sp SNTG1_HUMAN 37.702 496 270 6 3 465 9 498 2.60E-109 336 SNTG1_HUMAN reviewed Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4) SNTG1 Homo sapiens (Human) 517 cell communication [GO:0007154]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005198; GO:0005634; GO:0005737; GO:0005856; GO:0007154; GO:0008022; GO:0016013; GO:0032587; GO:0098779; GO:0098792 0 0 0 PF00595; Q9TT91 CHOYP_LOC100017943.1.1 m.54590 sp MKRN1_MACEU 44.388 392 204 5 11 392 51 438 2.60E-117 353 MKRN1_MACEU reviewed E3 ubiquitin-protein ligase makorin-1 (EC 6.3.2.-) MKRN1 Macropus eugenii (Tammar wallaby) 478 protein ubiquitination [GO:0016567] GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15815;PF00097;PF00642; Q9UMZ3 CHOYP_PTPRQ.3.8 m.23139 sp PTPRQ_HUMAN 26.554 354 212 16 8 328 97 435 2.60E-08 59.3 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; A0A0R4IBK5 CHOYP_contig_045459 m.52869 sp R213A_DANRE 19.658 585 361 23 89 656 221 713 2.61E-06 55.5 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A8MXQ7 CHOYP_BRAFLDRAFT_128799.1.1 m.29183 sp YH010_HUMAN 40.76 579 296 5 26 577 42 600 2.61E-134 407 YH010_HUMAN reviewed Putative IQ motif and ankyrin repeat domain-containing protein LOC642574 0 Homo sapiens (Human) 604 0 0 0 0 0 0 B4F6U4 CHOYP_BRAFLDRAFT_125682.1.1 m.55357 sp PRD10_XENTR 42.829 516 236 11 792 1296 548 1015 2.61E-123 415 PRD10_XENTR reviewed PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) prdm10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1173 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008168; GO:0046872 0 0 0 PF13912; D2GXS7 CHOYP_BRAFLDRAFT_63298.1.6 m.23976 sp TRIM2_AILME 32.432 111 69 4 59 166 625 732 2.61E-09 58.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2A0N4 CHOYP_PIF.1.6 m.7810 sp PIF_PINMG 27.835 291 166 8 445 700 258 539 2.61E-22 106 PIF_PINMG reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada margaritifera (Black-lipped pearl oyster) 1014 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607;PF00092; I3LM39 CHOYP_LOC100375194.6.7 m.53438 sp CGAS_PIG 26.531 196 118 8 202 376 294 484 2.61E-07 57.4 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O01725 CHOYP_RLA2.2.9 m.14455 sp RLA2_BRAFL 65.517 58 20 0 3 60 1 58 2.61E-20 82 RLA2_BRAFL reviewed 60S acidic ribosomal protein P2 0 Branchiostoma floridae (Florida lancelet) (Amphioxus) 116 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O01761 CHOYP_CRE-UNC-89.2.3 m.57007 sp UNC89_CAEEL 25.496 353 208 15 6 332 4542 4865 2.61E-09 65.5 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O43301 CHOYP_LOC100372773.6.9 m.57026 sp HS12A_HUMAN 27.925 641 369 20 10 574 48 671 2.61E-62 220 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O50655 CHOYP_LOC100632495.6.11 m.15023 sp XERD_SELRU 26.299 308 206 8 51 347 42 339 2.61E-17 85.1 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O60242 CHOYP_LOC100702950.2.4 m.3502 sp AGRB3_HUMAN 24.704 676 405 19 255 864 524 1161 2.61E-53 207 AGRB3_HUMAN reviewed Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) ADGRB3 BAI3 KIAA0550 Homo sapiens (Human) 1522 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; myoblast fusion [GO:0007520]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965]; regulation of dendrite morphogenesis [GO:0048814] GO:0004930; GO:0005096; GO:0005886; GO:0007166; GO:0007186; GO:0007520; GO:0016021; GO:0016525; GO:0048814; GO:0051965 0 0 0 PF00002;PF16489;PF01825;PF02793;PF00090; O75382 CHOYP_BRAFLDRAFT_69764.16.19 m.53316 sp TRIM3_HUMAN 22.619 336 223 9 36 352 427 744 2.61E-10 65.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75581 CHOYP_LRP1.1.5 m.6411 sp LRP6_HUMAN 25.665 865 583 30 158 996 100 930 2.61E-73 271 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; O88281 CHOYP_MEGF6.19.59 m.31775 sp MEGF6_RAT 37.791 344 154 16 195 494 867 1194 2.61E-41 162 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P41594 CHOYP_LOC100374272.4.6 m.54652 sp GRM5_HUMAN 23.093 485 329 15 538 997 29 494 2.61E-33 144 GRM5_HUMAN reviewed Metabotropic glutamate receptor 5 (mGluR5) GRM5 GPRC1E MGLUR5 Homo sapiens (Human) 1212 "chemical synaptic transmission [GO:0007268]; cognition [GO:0050890]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; learning [GO:0007612]; locomotory behavior [GO:0007626]; phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [GO:0007206]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0004930; GO:0005737; GO:0005886; GO:0005887; GO:0007205; GO:0007206; GO:0007216; GO:0007268; GO:0007612; GO:0007626; GO:0008066; GO:0014069; GO:0043005; GO:0048169; GO:0050890; GO:0051966; GO:0070062 0 0 0 PF00003;PF01094;PF10606;PF07562; P48166 CHOYP_CPIPJ_CPIJ007723.1.4 m.5854 sp RL36A_CAEEL 77.885 104 22 1 31 134 3 105 2.61E-52 163 RL36A_CAEEL reviewed Ribosomal protein L36.A (60S ribosomal protein L44) (L41) rpl-36.A rpl-41 C09H10.2 Caenorhabditis elegans 105 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00935; P84082 CHOYP_ARF2.2.3 m.48909 sp ARF2_RAT 92.208 154 12 0 1 154 1 154 2.61E-104 299 ARF2_RAT reviewed ADP-ribosylation factor 2 Arf2 Rattus norvegicus (Rat) 181 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; P86854 CHOYP_LOC101067775.1.1 m.66528 sp PLCL_MYTGA 29.412 136 86 5 125 259 30 156 2.61E-13 68.9 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P86854 CHOYP_LOC101240010.1.1 m.37815 sp PLCL_MYTGA 23.387 124 91 3 123 244 26 147 2.61E-08 55.1 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q01105 CHOYP_LOC101067281.2.2 m.62002 sp SET_HUMAN 77.83 212 46 1 42 252 24 235 2.61E-116 338 SET_HUMAN reviewed Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) 290 "DNA replication [GO:0006260]; negative regulation of histone acetylation [GO:0035067]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of mRNA stability [GO:0043488]; viral process [GO:0016032]" GO:0003677; GO:0004864; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0006260; GO:0006334; GO:0006337; GO:0006913; GO:0008601; GO:0016032; GO:0035067; GO:0042393; GO:0043234; GO:0043488; GO:0043524; GO:0045892; GO:0048471 0 0 0 PF00956; Q15468 CHOYP_LOC100368156.1.1 m.6837 sp STIL_HUMAN 39.588 437 237 9 29 447 18 445 2.61E-83 303 STIL_HUMAN reviewed SCL-interrupting locus protein (TAL-1-interrupting locus protein) STIL SIL Homo sapiens (Human) 1287 cell proliferation [GO:0008283]; centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; smoothened signaling pathway [GO:0007224] GO:0000578; GO:0001701; GO:0001843; GO:0001947; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0007052; GO:0007224; GO:0007368; GO:0008283; GO:0021915; GO:0030900; GO:0030903; GO:0033504; GO:0035264; GO:0043066; GO:0046599; GO:0051298; GO:0071539 0 0 0 PF15253; Q1RMK1 CHOYP_BRAFLDRAFT_57402.3.3 m.26347 sp FA92B_BOVIN 48.198 222 113 1 179 400 4 223 2.61E-71 231 FA92B_BOVIN reviewed Protein FAM92B FAM92B Bos taurus (Bovine) 288 0 0 0 0 0 PF06730; Q460N5 CHOYP_LOC100928016.2.6 m.36840 sp PAR14_HUMAN 26.121 379 237 7 1 376 798 1136 2.61E-29 124 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q503L9 CHOYP_LOC100633077.3.4 m.12059 sp NXN_DANRE 49.541 109 55 0 4 112 175 283 2.61E-34 125 NXN_DANRE reviewed Nucleoredoxin (EC 1.8.1.8) nxn zgc:110449 Danio rerio (Zebrafish) (Brachydanio rerio) 418 cardiovascular system development [GO:0072358]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005829; GO:0016055; GO:0030154; GO:0030178; GO:0031397; GO:0045454; GO:0047134; GO:0072358 0 0 0 PF13905; Q54KA7 CHOYP_TVAG_375250.1.1 m.32962 sp SECG_DICDI 34.156 243 126 1 1 209 222 464 2.61E-38 143 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5R788 CHOYP_LOC724467.1.1 m.38548 sp ISCA2_PONAB 44.872 156 79 2 35 186 1 153 2.61E-45 149 ISCA2_PONAB reviewed "Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1)" ISCA2 HBLD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 154 iron-sulfur cluster assembly [GO:0016226] GO:0005198; GO:0005739; GO:0016226; GO:0046872; GO:0051536 0 0 0 PF01521; Q5RJ80 CHOYP_LOC101165018.4.5 m.49711 sp CAPR2_DANRE 32.576 132 69 5 255 375 785 907 2.61E-08 59.3 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q63369 CHOYP_NFKB1.1.1 m.40096 sp NFKB1_RAT 26.344 186 117 8 245 424 78 249 2.61E-06 53.5 NFKB1_RAT reviewed Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment) Nfkb1 Rattus norvegicus (Rat) 522 "cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to carbohydrate stimulus [GO:0071322]; cellular response to cytokine stimulus [GO:0071345]; cellular response to diterpene [GO:1904630]; cellular response to glucoside [GO:1904632]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to organic cyclic compound [GO:0071407]; cellular response to peptide [GO:1901653]; cellular response to tumor necrosis factor [GO:0071356]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of gene expression [GO:0010628]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895]; response to bacterium [GO:0009617]; response to copper ion [GO:0046688]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000976; GO:0000977; GO:0000981; GO:0003677; GO:0003682; GO:0003690; GO:0003700; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006954; GO:0006979; GO:0007249; GO:0009617; GO:0010628; GO:0014070; GO:0031072; GO:0033256; GO:0038061; GO:0042803; GO:0043005; GO:0043066; GO:0043234; GO:0043565; GO:0045087; GO:0046688; GO:0046982; GO:0071222; GO:0071322; GO:0071345; GO:0071347; GO:0071356; GO:0071407; GO:1901653; GO:1902895; GO:1904630; GO:1904632; GO:1990416; GO:2000637 0 0 0 PF12796;PF00531; Q6DGP2 CHOYP_BRAFLDRAFT_238139.1.1 m.12224 sp SYF2_DANRE 64.929 211 74 0 20 230 28 238 2.61E-94 278 SYF2_DANRE reviewed Pre-mRNA-splicing factor syf2 syf2 zgc:92835 Danio rerio (Zebrafish) (Brachydanio rerio) 238 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0000974; GO:0071010; GO:0071012; GO:0071013; GO:0071014 0 0 0 PF08231; Q6INX1 CHOYP_TMM98.1.1 m.51750 sp TMM98_XENLA 51.852 216 101 1 1 216 1 213 2.61E-69 215 TMM98_XENLA reviewed Transmembrane protein 98 tmem98 Xenopus laevis (African clawed frog) 226 0 GO:0016021 0 0 0 0 Q6P3S1 CHOYP_LOC100878846.1.1 m.56155 sp DEN1B_HUMAN 41.818 495 250 6 1 473 1 479 2.61E-131 416 DEN1B_HUMAN reviewed DENN domain-containing protein 1B (Connecdenn 2) (Protein FAM31B) DENND1B C1orf218 FAM31B Homo sapiens (Human) 775 endocytic recycling [GO:0032456]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell cytokine production [GO:0035745] GO:0005829; GO:0015031; GO:0017112; GO:0030136; GO:0032456; GO:0035745; GO:0050776; GO:0050852 0 0 0 PF03455;PF02141;PF03456; Q6PCN3 CHOYP_LOC100908717.1.1 m.45624 sp TTBK1_MOUSE 63.687 358 118 2 8 363 22 369 2.61E-158 509 TTBK1_MOUSE reviewed Tau-tubulin kinase 1 (EC 2.7.11.1) Ttbk1 Mus musculus (Mouse) 1308 peptidyl-serine phosphorylation [GO:0018105]; regulation of cell shape [GO:0008360]; substantia nigra development [GO:0021762] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0008360; GO:0018105; GO:0021762 0 0 0 PF00069; Q6ZUJ8 CHOYP_PIK3AP1.1.1 m.43157 sp BCAP_HUMAN 28.346 127 86 2 2 123 266 392 2.61E-11 65.1 BCAP_HUMAN reviewed Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Homo sapiens (Human) 805 negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] GO:0005829; GO:0005886; GO:0014068; GO:0016020; GO:0034122; GO:0034123; GO:0034134; GO:0034142; GO:0034154; GO:0034162; GO:0036312; GO:0050727 0 0 0 PF14545; Q8BGM5 CHOYP_BEST1.1.1 m.3044 sp BEST2_MOUSE 51.142 219 104 2 21 236 161 379 2.61E-68 233 BEST2_MOUSE reviewed Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1) Best2 Vmd2l1 Mus musculus (Mouse) 508 chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; membrane depolarization [GO:0051899]; sensory perception of smell [GO:0007608] GO:0005254; GO:0005887; GO:0005929; GO:0006821; GO:0007608; GO:0034707; GO:0051899; GO:1902476 0 0 0 PF01062; Q8C206 CHOYP_NEMVEDRAFT_V1G202568.1.1 m.54783 sp GP157_MOUSE 31.95 241 133 4 129 350 79 307 2.61E-22 99.4 GP157_MOUSE reviewed Probable G-protein coupled receptor 157 Gpr157 Mus musculus (Mouse) 330 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021 0 0 0 PF00002; Q8C9W3 CHOYP_ATS16.4.4 m.59385 sp ATS2_MOUSE 23.545 773 458 33 97 796 123 835 2.61E-43 175 ATS2_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) Adamts2 Mus musculus (Mouse) 1213 collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; lung development [GO:0030324]; protein processing [GO:0016485]; skin development [GO:0043588]; spermatogenesis [GO:0007283] GO:0004222; GO:0005578; GO:0007283; GO:0008233; GO:0008270; GO:0016485; GO:0030199; GO:0030324; GO:0030574; GO:0043588 0 0 0 PF05986;PF01562;PF01421;PF00090; Q8JIS3 CHOYP_BRAFLDRAFT_200527.1.1 m.602 sp DER_CHICK 55.983 234 103 0 1 234 10 243 2.61E-90 269 DER_CHICK reviewed D-erythrulose reductase (EC 1.1.1.162) (Probable L-xylulose reductase) (XR) (EC 1.1.1.10) DER Gallus gallus (Chicken) 246 D-xylose metabolic process [GO:0042732] GO:0005737; GO:0042732; GO:0047880; GO:0050038 0 0 0 0 Q8WQI5 CHOYP_LOC100204649.1.1 m.19920 sp RS8_SPOFR 65.865 208 71 0 3 210 1 208 2.61E-100 292 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q91WM2 CHOYP_CECR5.1.1 m.40220 sp CECR5_MOUSE 46.951 164 80 2 1 161 193 352 2.61E-46 160 CECR5_MOUSE reviewed Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) 419 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q96GP6 CHOYP_MEGF6.20.59 m.32515 sp SREC2_HUMAN 40 150 84 5 187 336 236 379 2.61E-18 89.7 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9BRZ2 CHOYP_LOC100367973.1.3 m.41476 sp TRI56_HUMAN 23.86 285 170 9 16 275 16 278 2.61E-15 80.5 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9NQV7 CHOYP_LOC100186221.1.1 m.10713 sp PRDM9_HUMAN 29.353 201 134 5 97 293 171 367 2.61E-19 93.6 PRDM9_HUMAN reviewed Histone-lysine N-methyltransferase PRDM9 (EC 2.1.1.43) (PR domain zinc finger protein 9) (PR domain-containing protein 9) PRDM9 PFM6 Homo sapiens (Human) 894 "meiotic gene conversion [GO:0006311]; positive regulation of reciprocal meiotic recombination [GO:0010845]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005654; GO:0005694; GO:0006311; GO:0006351; GO:0006355; GO:0010845; GO:0018024; GO:0046872 0 0 cd07765; PF01352;PF00856;PF09514;PF00096;PF13912; Q9NYT6 CHOYP_ZN510.1.1 m.28582 sp ZN226_HUMAN 37.688 199 112 3 387 579 362 554 2.61E-35 145 ZN226_HUMAN reviewed Zinc finger protein 226 ZNF226 Homo sapiens (Human) 803 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q9R1R2 CHOYP_BRAFLDRAFT_205965.26.43 m.46277 sp TRIM3_MOUSE 25.161 155 110 3 29 181 593 743 2.61E-09 59.7 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9WVR6 CHOYP_LAT1.1.2 m.29718 sp LAT2_RAT 45.344 494 262 4 4 490 7 499 2.61E-141 419 LAT2_RAT reviewed Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (Solute carrier family 7 member 8) Slc7a8 Lat2 Lat4 Rattus norvegicus (Rat) 533 neutral amino acid transport [GO:0015804] GO:0005737; GO:0005887; GO:0015101; GO:0015171; GO:0015175; GO:0015179; GO:0015297; GO:0015804; GO:0016323; GO:0019534; GO:0042605; GO:0070062 0 0 0 PF13520; B5X5D0 CHOYP_LOC100378844.2.4 m.11592 sp CI116_SALSA 40 110 65 1 10 118 5 114 2.62E-25 95.9 CI116_SALSA reviewed UPF0691 protein C9orf116 homolog 0 Salmo salar (Atlantic salmon) 141 0 0 0 0 0 0 D3Z813 CHOYP_ISCW_ISCW007017.1.1 m.21847 sp S38AB_RAT 45.558 439 230 4 33 471 19 448 2.62E-127 380 S38AB_RAT reviewed Putative sodium-coupled neutral amino acid transporter 11 (Solute carrier family 38 member 11) Slc38a11 Rattus norvegicus (Rat) 453 amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; sodium ion transport [GO:0006814] GO:0003333; GO:0005783; GO:0006814; GO:0006865; GO:0015171; GO:0016021 0 0 0 PF01490; D3ZTX0 CHOYP_TMED7.3.3 m.62433 sp TMED7_RAT 41.146 192 107 3 31 221 34 220 2.62E-48 161 TMED7_RAT reviewed Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) Tmed7 Rattus norvegicus (Rat) 226 protein transport [GO:0015031] GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0012507; GO:0015031; GO:0016021; GO:0030663; GO:0033116; GO:0070062 0 0 0 PF01105; O13395 CHOYP_DGRI_GH22622.1.1 m.41607 sp CHS6_USTMA 32.804 189 113 6 307 482 560 747 2.62E-16 85.9 CHS6_USTMA reviewed Chitin synthase 6 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 6) (Class-V chitin synthase 6) CHS6 UMAG_10367 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 1180 cell wall organization [GO:0071555] GO:0003677; GO:0004100; GO:0005886; GO:0016021; GO:0030659; GO:0071555 0 0 0 PF00173;PF08766; P03354 CHOYP_contig_020522 m.23700 sp POL_RSVP 31.461 89 53 2 121 204 504 589 2.62E-06 51.2 POL_RSVP reviewed Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27; p3; Nucleocapsid protein p12; Protease p15 (EC 3.4.23.-); Reverse transcriptase beta-subunit (RT-beta) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Reverse transcriptase alpha-subunit (RT-alpha) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (pp32); p4] gag-pro-pol Rous sarcoma virus (strain Prague C) (RSV-PrC) 1603 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0005198; GO:0006310; GO:0008270; GO:0015074; GO:0019013; GO:0046718; GO:0075713 0 0 0 PF00607;PF00552;PF02022;PF02813;PF00665;PF00077;PF00078;PF06817;PF00098; P09889 CHOYP_PPA5.1.1 m.36087 sp PPA5_PIG 49.505 303 145 6 35 335 34 330 2.62E-101 305 PPA5_PIG reviewed Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase) (Uteroferrin) (UF) ACP5 Sus scrofa (Pig) 340 ion transport [GO:0006811]; iron ion homeostasis [GO:0055072] GO:0003993; GO:0005576; GO:0006811; GO:0008198; GO:0008199; GO:0055072 0 0 0 PF00149; P11678 CHOYP_LOC100160088.1.1 m.66599 sp PERE_HUMAN 37.669 592 311 16 237 793 145 713 2.62E-120 381 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P28648 CHOYP_AGAP_AGAP004861.2.2 m.54567 sp CD63_RAT 32.195 205 107 10 83 282 57 234 2.62E-15 76.6 CD63_RAT reviewed CD63 antigen (Mast cell antigen AD1) (CD antigen CD63) Cd63 Rattus norvegicus (Rat) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigment granule maturation [GO:0048757]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endocytosis [GO:0045807]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005737; GO:0005764; GO:0005765; GO:0005886; GO:0005887; GO:0007160; GO:0007166; GO:0010633; GO:0012505; GO:0015031; GO:0016021; GO:0016477; GO:0030658; GO:0030855; GO:0031226; GO:0031902; GO:0032403; GO:0035646; GO:0042470; GO:0043234; GO:0045785; GO:0045807; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2001046 0 0 0 PF00335; P35408 CHOYP_PE2R3.2.2 m.61864 sp PE2R4_HUMAN 24.599 374 231 9 3 329 2 371 2.62E-28 117 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; Q008S8 CHOYP_LOC100369302.3.3 m.65811 sp ECT2L_HUMAN 45.609 353 187 3 807 1159 556 903 2.62E-91 317 ECT2L_HUMAN reviewed Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH) ECT2L C6orf91 LFDH Homo sapiens (Human) 904 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF14252;PF12937;PF00621; Q0IHB8 CHOYP_BRAFLDRAFT_124882.1.1 m.66683 sp OSR2B_XENLA 82.979 94 16 0 186 279 161 254 2.62E-51 172 OSR2B_XENLA reviewed Protein odd-skipped-related 2-B osr2-b osr2 Xenopus laevis (African clawed frog) 271 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pronephros development [GO:0048793]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003676; GO:0005634; GO:0006351; GO:0045892; GO:0046872; GO:0048793 0 0 0 0 Q3THS6 CHOYP_METK2.2.3 m.38600 sp METK2_MOUSE 74.118 255 66 0 36 290 16 270 2.62E-143 413 METK2_MOUSE reviewed S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) Mat2a Mus musculus (Mouse) 395 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0005829; GO:0006556; GO:0006730; GO:0046872; GO:0048269 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q5BIM1 CHOYP_BRAFLDRAFT_82869.6.6 m.66092 sp TRI45_BOVIN 23.59 195 124 4 12 204 133 304 2.62E-09 62 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5BJ68 CHOYP_BRAFLDRAFT_120433.1.1 m.66614 sp NB5R2_XENTR 62.976 289 105 2 11 299 9 295 2.62E-139 399 NB5R2_XENTR reviewed NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2) cyb5r2 TNeu132f07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 304 response to yeast [GO:0001878]; sterol biosynthetic process [GO:0016126] GO:0001878; GO:0004128; GO:0005739; GO:0016021; GO:0016126; GO:0071949 0 0 0 PF00970;PF00175; Q5BK24 CHOYP_LOC101319591.1.1 m.7084 sp CH076_RAT 36.923 130 79 2 3 131 8 135 2.62E-17 80.1 CH076_RAT reviewed Uncharacterized protein C8orf76 homolog 0 Rattus norvegicus (Rat) 374 0 0 0 0 0 0 Q5BK63 CHOYP_NDUA9.1.1 m.58478 sp NDUA9_RAT 39.412 340 174 6 171 502 55 370 2.62E-71 234 NDUA9_RAT reviewed "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Sperm flagella protein 3)" Ndufa9 Rattus norvegicus (Rat) 377 response to glucose [GO:0009749]; ubiquinone-6 biosynthetic process [GO:1901006] GO:0003954; GO:0005739; GO:0005747; GO:0005759; GO:0009749; GO:1901006 0 0 0 PF05368; Q5XHB2 CHOYP_PSMC6.1.1 m.13889 sp DUS22_XENTR 55.294 170 76 0 1 170 1 170 2.62E-67 211 DUS22_XENTR reviewed Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) dusp22 TEgg009e03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 209 positive regulation of JNK cascade [GO:0046330]; regulation of cell proliferation [GO:0042127]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0004725; GO:0005634; GO:0005737; GO:0007179; GO:0008138; GO:0042127; GO:0046330 0 0 0 PF00782; Q6DGQ4 CHOYP_LOC100374696.1.1 m.18701 sp CP087_DANRE 29.412 170 87 4 12 179 10 148 2.62E-10 59.7 CP087_DANRE reviewed UPF0547 protein C16orf87 homolog zgc:92818 Danio rerio (Zebrafish) (Brachydanio rerio) 152 0 0 0 0 0 PF10571; Q6NUA7 CHOYP_SIL1.1.2 m.23760 sp SIL1_XENLA 34.974 386 229 7 62 441 38 407 2.62E-65 221 SIL1_XENLA reviewed Nucleotide exchange factor SIL1 sil1 Xenopus laevis (African clawed frog) 456 protein transport [GO:0015031] GO:0005788; GO:0015031 0 0 0 0 Q6Q899 CHOYP_IFIH1.3.14 m.24387 sp DDX58_MOUSE 29.839 496 305 16 135 612 14 484 2.62E-45 176 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6ZNE5 CHOYP_BAKOR.2.2 m.35514 sp BAKOR_HUMAN 36.268 477 273 13 13 468 21 487 2.62E-77 253 BAKOR_HUMAN reviewed Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) ATG14 ATG14L KIAA0831 Homo sapiens (Human) 492 autophagosome assembly [GO:0000045]; cellular response to glucose starvation [GO:0042149]; cellular response to starvation [GO:0009267]; endosome to lysosome transport [GO:0008333]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of autophagy [GO:0010508]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein phosphorylation [GO:0001934]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of protein complex stability [GO:0061635]; regulation of protein phosphorylation [GO:0001932]; regulation of triglyceride metabolic process [GO:0090207] GO:0000045; GO:0000421; GO:0001932; GO:0001933; GO:0001934; GO:0005634; GO:0005737; GO:0005776; GO:0005789; GO:0005829; GO:0005930; GO:0008333; GO:0009267; GO:0010508; GO:0010608; GO:0016236; GO:0034045; GO:0035032; GO:0042149; GO:0043552; GO:0044233; GO:0045335; GO:0061635; GO:0090207; GO:0097629; GO:0097632; GO:0098779 0 0 0 PF10186; Q6ZV65 CHOYP_LOC100889336.1.1 m.18327 sp FA47E_HUMAN 33.083 133 88 1 116 248 228 359 2.62E-14 76.3 FA47E_HUMAN reviewed Protein FAM47E FAM47E Homo sapiens (Human) 393 0 0 0 0 0 PF14642; Q80V70 CHOYP_BRAFLDRAFT_224636.1.1 m.56282 sp MEGF6_MOUSE 44.898 49 26 1 33 81 1359 1406 2.62E-07 57 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q810U3 CHOYP_PGBM.2.3 m.44777 sp NFASC_MOUSE 26.247 381 227 17 269 638 261 598 2.62E-19 97.1 NFASC_MOUSE reviewed Neurofascin Nfasc Mus musculus (Mouse) 1240 axon guidance [GO:0007411]; clustering of voltage-gated sodium channels [GO:0045162]; paranodal junction assembly [GO:0030913]; peripheral nervous system development [GO:0007422]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein targeting to plasma membrane [GO:0072661]; synapse organization [GO:0050808]; transmission of nerve impulse [GO:0019226] GO:0002175; GO:0005622; GO:0005886; GO:0005925; GO:0007411; GO:0007422; GO:0016021; GO:0019226; GO:0030424; GO:0030913; GO:0033010; GO:0033268; GO:0033270; GO:0043194; GO:0043209; GO:0045162; GO:0050808; GO:0070062; GO:0071205; GO:0072661; GO:0086080; GO:0097454 0 0 0 PF13882;PF00041;PF07679;PF00047; Q8CIR4 CHOYP_SMP_173720.3.3 m.58574 sp TRPM6_MOUSE 27.006 1159 622 30 11 1033 41 1111 2.62E-115 396 TRPM6_MOUSE reviewed Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) Trpm6 Mus musculus (Mouse) 2028 metal ion transport [GO:0030001]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636] GO:0004674; GO:0005261; GO:0005262; GO:0005524; GO:0009636; GO:0016021; GO:0016324; GO:0030001; GO:0031526; GO:0046872; GO:0051262 0 0 0 PF02816;PF00520;PF16519; Q8IVG5 CHOYP_LOC100367581.1.3 m.10754 sp SAM9L_HUMAN 23.486 941 577 35 15 885 716 1583 2.62E-40 166 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8R1F0 CHOYP_PAM.1.1 m.27520 sp L10K_MOUSE 39.56 91 52 1 11 101 1 88 2.62E-13 63.5 L10K_MOUSE reviewed Leydig cell tumor 10 kDa protein homolog D8Ertd738e Mus musculus (Mouse) 94 0 0 0 0 0 PF09495; Q8WQI5 CHOYP_RS8.5.14 m.32289 sp RS8_SPOFR 63.736 91 31 1 129 219 120 208 2.62E-31 116 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q8WTR4 CHOYP_GDPD5.1.1 m.6143 sp GDPD5_HUMAN 35.762 604 366 7 12 607 1 590 2.62E-131 404 GDPD5_HUMAN reviewed Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2) GDPD5 GDE2 PP6037 PP9363 UNQ1850/PRO3580 Homo sapiens (Human) 605 cerebral cortex neuron differentiation [GO:0021895]; lipid metabolic process [GO:0006629]; negative regulation of Notch signaling pathway [GO:0045746]; neuron projection development [GO:0031175]; positive regulation of cell cycle [GO:0045787]; positive regulation of neuron differentiation [GO:0045666]; regulation of timing of cell differentiation [GO:0048505]; spinal cord motor neuron differentiation [GO:0021522] GO:0006629; GO:0008889; GO:0016021; GO:0021522; GO:0021895; GO:0030424; GO:0030426; GO:0031175; GO:0043025; GO:0045666; GO:0045746; GO:0045787; GO:0047389; GO:0048505; GO:0097038 0 0 0 PF03009; Q96DM1 CHOYP_LOC100661020.1.5 m.12492 sp PGBD4_HUMAN 26.799 403 261 12 1 382 192 581 2.62E-30 125 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9CRB3 CHOYP_LOC101373190.1.1 m.16097 sp HIUH_MOUSE 51.327 113 52 3 111 221 7 118 2.62E-30 111 HIUH_MOUSE reviewed 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein) Urah Mus musculus (Mouse) 118 purine nucleobase metabolic process [GO:0006144]; urate catabolic process [GO:0019628] GO:0005739; GO:0005777; GO:0006144; GO:0016787; GO:0019628; GO:0033971 PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. 0 0 PF00576; Q9DBB9 CHOYP_LOC100892728.1.1 m.33341 sp CPN2_MOUSE 27.149 442 259 16 28 460 22 409 2.62E-20 97.8 CPN2_MOUSE reviewed Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) Cpn2 Mus musculus (Mouse) 547 0 GO:0070062; GO:0072562 0 0 0 PF13855; Q9ESN6 CHOYP_contig_028470 m.32415 sp TRIM2_MOUSE 27.234 235 142 11 178 401 515 731 2.62E-08 59.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JKM7 CHOYP_LOC100052585.1.1 m.55922 sp RAB37_MOUSE 69.11 191 59 0 3 193 31 221 2.62E-97 284 RAB37_MOUSE reviewed Ras-related protein Rab-37 Rab37 Mus musculus (Mouse) 223 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005793; GO:0007264; GO:0015031; GO:0030141 0 0 0 PF00071; Q9QWT9 CHOYP_KIF2.1.2 m.46179 sp KIFC1_MOUSE 34.101 217 103 6 224 406 231 441 2.62E-24 108 KIFC1_MOUSE reviewed Kinesin-like protein KIFC1 Kifc1 Kifc4 Kifc5a Kifc5b Mus musculus (Mouse) 674 cell division [GO:0051301]; minus-end-directed vesicle transport along microtubule [GO:0072382]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; negative regulation of centrosome duplication [GO:0010826]; vesicle transport along microtubule [GO:0047496] GO:0003777; GO:0005524; GO:0005634; GO:0005769; GO:0005871; GO:0005874; GO:0007080; GO:0008569; GO:0010826; GO:0016020; GO:0030139; GO:0031616; GO:0047496; GO:0051301; GO:0072382; GO:0072686; GO:0090307 0 0 0 PF00225; Q9QYP1 CHOYP_LOC578599.4.8 m.37368 sp LRP4_RAT 29.391 575 378 16 32 589 785 1348 2.62E-60 224 LRP4_RAT reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0034185; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q9UGM3 CHOYP_TRIADDRAFT_52608.2.2 m.66746 sp DMBT1_HUMAN 45.327 214 104 6 2022 2227 494 702 2.62E-43 179 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UUH0 CHOYP_LOC763638.1.1 m.24748 sp YKIC_SCHPO 28.889 180 116 6 116 286 43 219 2.62E-14 77.8 YKIC_SCHPO reviewed Uncharacterized protein C630.12 SPAC630.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 422 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0005783; GO:0005789; GO:0006888; GO:0016021; GO:0016787 0 0 0 PF00149; A2BD94 CHOYP_LOC100377168.3.3 m.64524 sp FB31B_XENLA 29.825 456 241 11 12 409 62 496 2.63E-50 180 FB31B_XENLA reviewed F-box only protein 31-B fbxo31-b Xenopus laevis (African clawed frog) 523 cellular response to DNA damage stimulus [GO:0006974]; mitotic G1 DNA damage checkpoint [GO:0031571]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0006974; GO:0008054; GO:0016567; GO:0019005; GO:0031146; GO:0031571 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; A3KQA5 CHOYP_BRAFLDRAFT_275083.1.2 m.30833 sp ODF3B_DANRE 54.237 236 105 2 7 242 15 247 2.63E-78 239 ODF3B_DANRE reviewed Outer dense fiber protein 3-B (Outer dense fiber of sperm tails protein 3-B) (Outer dense fiber protein 3-like) odf3b odf3 odf3l si:dkey-238c7.9 si:dkeyp-1h4.4 zgc:63985 Danio rerio (Zebrafish) (Brachydanio rerio) 257 0 GO:0005737 0 0 0 PF07004; A3RLT6 CHOYP_RSSA.8.10 m.48913 sp RSSA_PINFU 92.857 182 13 0 5 186 1 182 2.63E-116 336 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A4FUP9 CHOYP_GL1D1.3.3 m.57117 sp GL1D1_MOUSE 37.445 227 140 2 1 227 117 341 2.63E-49 167 GL1D1_MOUSE reviewed Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) Glt1d1 Mus musculus (Mouse) 346 0 GO:0005576; GO:0005737; GO:0016757 0 0 0 PF00534; A8Y1P7 CHOYP_BETA4GALNACTA.1.2 m.35036 sp BRE4_CAEBR 44.074 270 147 2 45 310 96 365 2.63E-74 236 BRE4_CAEBR reviewed "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 CBG22165 Caenorhabditis briggsae 384 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0016757; GO:0046872 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9GUM2}. 0 0 PF02709;PF13733; F1LMN3 CHOYP_E2F7.1.2 m.11637 sp E2F8_RAT 41.646 401 180 11 133 506 56 429 2.63E-76 270 E2F8_RAT reviewed Transcription factor E2F8 (E2F-8) E2f8 Rattus norvegicus (Rat) 860 "cell cycle comprising mitosis without cytokinesis [GO:0033301]; chorionic trophoblast cell differentiation [GO:0060718]; hepatocyte differentiation [GO:0070365]; negative regulation of cytokinesis [GO:0032466]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; placenta development [GO:0001890]; positive regulation of DNA endoreduplication [GO:0032877]; sprouting angiogenesis [GO:0002040]; transcription, DNA-templated [GO:0006351]; trophoblast giant cell differentiation [GO:0060707]" GO:0000122; GO:0001890; GO:0002040; GO:0003677; GO:0003700; GO:0003714; GO:0005634; GO:0005667; GO:0006351; GO:0032466; GO:0032877; GO:0033301; GO:0060707; GO:0060718; GO:0070365 0 0 0 PF02319; F4KD71 CHOYP_LOC100367180.1.1 m.21019 sp DUR3_ARATH 29.238 407 263 6 51 440 41 439 2.63E-41 164 DUR3_ARATH reviewed Urea-proton symporter DUR3 (AtDUR3) (High-affinity urea active transporter DUR3) DUR3 At5g45380 MFC19.5 Arabidopsis thaliana (Mouse-ear cress) 704 urea transmembrane transport [GO:0071918] GO:0005887; GO:0015204; GO:0015293; GO:0071918 0 0 0 PF00474; O00625 CHOYP_LOC584062.1.1 m.62279 sp PIR_HUMAN 51.579 285 136 2 2 285 3 286 2.63E-105 311 PIR_HUMAN reviewed "Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)" PIR Homo sapiens (Human) 290 "monocyte differentiation [GO:0030224]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003712; GO:0005634; GO:0005737; GO:0006355; GO:0006366; GO:0008127; GO:0030224; GO:0046872 PATHWAY: Flavonoid metabolism; quercetin degradation. 0 0 PF02678;PF05726; O15990 CHOYP_LOC101174856.1.1 m.47586 sp KARG_LIOJA 61.682 214 81 1 26 238 1 214 2.63E-90 273 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O43402 CHOYP_BRAFLDRAFT_260197.1.1 m.8081 sp EMC8_HUMAN 40.976 205 107 3 8 200 1 203 2.63E-51 167 EMC8_HUMAN reviewed ER membrane protein complex subunit 8 (Neighbor of COX4) (Protein FAM158B) EMC8 C16orf2 C16orf4 COX4AL COX4NB FAM158B NOC4 Homo sapiens (Human) 210 0 GO:0005634; GO:0005737; GO:0005739; GO:0016020; GO:0072546 0 0 cd08060; PF03665; P17972 CHOYP_KCNC4.5.5 m.61308 sp KCNAW_DROME 30.435 437 264 9 9 419 14 436 2.63E-57 199 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P41824 CHOYP_LOC411194.1.1 m.8501 sp YBOXH_APLCA 76.033 121 19 1 1 111 1 121 2.63E-58 188 YBOXH_APLCA reviewed Y-box factor homolog (APY1) 0 Aplysia californica (California sea hare) 253 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355 0 0 cd04458; PF00313; P59222 CHOYP_MEGF6.59.59 m.67005 sp SREC2_MOUSE 40.404 99 57 2 195 293 227 323 2.63E-14 76.6 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; Q03168 CHOYP_LOC100371142.1.1 m.5611 sp ASPP_AEDAE 62.5 240 88 1 21 260 147 384 2.63E-108 321 ASPP_AEDAE reviewed Lysosomal aspartic protease (EC 3.4.23.-) AAEL006169 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 387 0 GO:0004190; GO:0005764 0 0 0 PF00026; Q03412 CHOYP_LOC100533356.4.6 m.41054 sp UNC7_CAEEL 42.276 123 71 0 25 147 138 260 2.63E-27 108 UNC7_CAEEL reviewed Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans 522 gap junction assembly [GO:0016264]; ion transmembrane transport [GO:0034220]; locomotion [GO:0040011]; oviposition [GO:0018991]; regulation of pharyngeal pumping [GO:0043051]; response to anesthetic [GO:0072347] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0016264; GO:0018991; GO:0032589; GO:0034220; GO:0040011; GO:0043051; GO:0055077; GO:0072347 0 0 0 PF00876; Q03601 CHOYP_BRAFLDRAFT_71598.2.10 m.13212 sp NHL1_CAEEL 25 160 107 5 76 226 725 880 2.63E-06 52.4 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q04787 CHOYP_BRAFLDRAFT_125486.1.1 m.18492 sp BSH_DROME 59.701 67 27 0 137 203 273 339 2.63E-17 85.1 BSH_DROME reviewed Brain-specific homeobox protein bsh CG10604 Drosophila melanogaster (Fruit fly) 429 "brain development [GO:0007420]; neuron fate commitment [GO:0048663]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0007420; GO:0043565; GO:0048663 0 0 0 PF00046; Q16819 CHOYP_MEP1B.3.4 m.27785 sp MEP1A_HUMAN 22.636 349 226 15 75 402 107 432 2.63E-18 90.9 MEP1A_HUMAN reviewed Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha) (PABA peptide hydrolase) (PPH alpha) MEP1A Homo sapiens (Human) 746 digestion [GO:0007586] GO:0004222; GO:0005615; GO:0005887; GO:0007586; GO:0008270; GO:0017090; GO:0070062 0 0 cd06263; PF01400;PF00008;PF00629; Q28DL4 CHOYP_LOC100372970.1.1 m.63357 sp TRAF6_XENTR 31.987 594 321 14 7 598 23 535 2.63E-88 288 TRAF6_XENTR reviewed TNF receptor-associated factor 6 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6 TNeu045k15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 558 immune response [GO:0006955]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] GO:0004842; GO:0005737; GO:0006955; GO:0007165; GO:0008270; GO:0016874; GO:0042981; GO:0070534 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02176; Q3SZ21 CHOYP_LOC100370537.1.1 m.10589 sp RPP30_BOVIN 38.71 248 133 6 3 246 4 236 2.63E-44 154 RPP30_BOVIN reviewed Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2) RPP30 RNASEP2 Bos taurus (Bovine) 268 "RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; tRNA processing [GO:0008033]" GO:0003723; GO:0004526; GO:0005655; GO:0008033; GO:0090502 0 0 0 PF01876; Q497V6 CHOYP_ISCW_ISCW000975.1.1 m.49723 sp BAHD1_MOUSE 39.544 263 146 8 571 824 513 771 2.63E-44 175 BAHD1_MOUSE reviewed Bromo adjacent homology domain-containing 1 protein (BAH domain-containing protein 1) Bahd1 Gm117 Kiaa0945 Mus musculus (Mouse) 772 "chromatin silencing [GO:0006342]; covalent chromatin modification [GO:0016569]; heterochromatin assembly [GO:0031507]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0000785; GO:0000976; GO:0003682; GO:0005654; GO:0005677; GO:0006342; GO:0006351; GO:0016569; GO:0031507; GO:0045892 0 0 0 PF01426; Q58DT1 CHOYP_RPL7.1.2 m.5542 sp RL7_BOVIN 54.762 84 38 0 13 96 9 92 2.63E-19 83.2 RL7_BOVIN reviewed 60S ribosomal protein L7 RPL7 Bos taurus (Bovine) 248 "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" GO:0000463; GO:0002181; GO:0003735; GO:0022625; GO:0044822 0 0 0 PF00327;PF08079; Q5I0K7 CHOYP_LOC100636340.1.4 m.5144 sp ALG13_RAT 55.556 144 63 1 17 159 5 148 2.63E-49 159 ALG13_RAT reviewed UDP-N-acetylglucosamine transferase subunit ALG13 homolog (EC 2.4.1.141) (Glycosyltransferase 28 domain-containing protein 1) Alg13 Glt28d1 Rattus norvegicus (Rat) 165 0 GO:0004577; GO:0005783 0 0 0 PF04101; Q5RJY2 CHOYP_LOC100537259.2.2 m.57231 sp G2E3_MOUSE 23.592 373 241 16 19 377 343 685 2.63E-07 56.2 G2E3_MOUSE reviewed G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) G2e3 Kiaa1333 Mus musculus (Mouse) 716 apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0001824; GO:0005730; GO:0005737; GO:0006915; GO:0008270; GO:0016874; GO:0061630; GO:2001243 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q5TGI4 CHOYP_LOC101164614.2.2 m.54369 sp SAMD5_HUMAN 43.312 157 83 3 1 155 1 153 2.63E-32 127 SAMD5_HUMAN reviewed Sterile alpha motif domain-containing protein 5 (SAM domain-containing protein 5) SAMD5 SAMDC1 Homo sapiens (Human) 173 0 0 0 0 0 PF00536; Q5XI63 CHOYP_CTK2.2.3 m.51997 sp KIFC1_RAT 41.388 389 173 11 285 630 316 692 2.63E-75 257 KIFC1_RAT reviewed Kinesin-like protein KIFC1 (Kinesin-related protein 1) Kifc1 Krp1 Rattus norvegicus (Rat) 693 cell division [GO:0051301]; microtubule-based movement [GO:0007018]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; spermatogenesis [GO:0007283] GO:0003777; GO:0005524; GO:0005634; GO:0005769; GO:0005815; GO:0005819; GO:0005871; GO:0005874; GO:0007018; GO:0007080; GO:0007283; GO:0016020; GO:0016887; GO:0051301; GO:0090307 0 0 0 PF00225; Q64516 CHOYP_BRAFLDRAFT_224325.1.3 m.26136 sp GLPK_MOUSE 65 100 35 0 1 100 417 516 2.63E-26 103 GLPK_MOUSE reviewed Glycerol kinase (GK) (Glycerokinase) (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) Gk Gyk Mus musculus (Mouse) 559 glucose homeostasis [GO:0042593]; glycerol-3-phosphate biosynthetic process [GO:0046167]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; regulation of fatty acid metabolic process [GO:0019217]; response to cold [GO:0009409]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; triglyceride metabolic process [GO:0006641] GO:0004370; GO:0005524; GO:0005634; GO:0005739; GO:0005741; GO:0005829; GO:0006071; GO:0006641; GO:0009409; GO:0019217; GO:0019563; GO:0042493; GO:0042593; GO:0045471; GO:0046167; GO:0070062 PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. 0 0 PF02782;PF00370; Q6BWA5 CHOYP_LOC100367353.1.1 m.32092 sp IPYR_DEBHA 61.111 288 105 4 55 340 1 283 2.63E-128 371 IPYR_DEBHA reviewed Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) IPP1 DEHA2B13090g Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) 287 phosphate-containing compound metabolic process [GO:0006796] GO:0000287; GO:0004427; GO:0005634; GO:0005737; GO:0006796 0 0 cd00412; PF00719; Q6P9T8 CHOYP_LOC100367715.1.1 m.65919 sp TBB4B_RAT 96.078 102 4 0 1 102 73 174 2.63E-67 212 TBB4B_RAT reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Rattus norvegicus (Rat) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q6P9T8 CHOYP_LOC101242512.1.1 m.48607 sp TBB4B_RAT 96.078 102 4 0 1 102 73 174 2.63E-67 212 TBB4B_RAT reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Rattus norvegicus (Rat) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q6PAM1 CHOYP_LOC100371254.1.1 m.1838 sp TXLNA_MOUSE 45.349 430 197 7 380 775 128 553 2.63E-95 311 TXLNA_MOUSE reviewed Alpha-taxilin Txlna Txln Mus musculus (Mouse) 554 B cell activation [GO:0042113]; exocytosis [GO:0006887]; mitophagy in response to mitochondrial depolarization [GO:0098779] GO:0005737; GO:0006887; GO:0016020; GO:0042113; GO:0098779 0 0 0 PF09728; Q6YV88 CHOYP_LOC100367956.2.2 m.62045 sp C71Z7_ORYSJ 29.365 126 79 2 15 130 8 133 2.63E-15 74.3 C71Z7_ORYSJ reviewed Ent-cassadiene C2-hydroxylase (EC 1.14.13.-) (Cytochrome P450 71Z7) CYP71Z7 Os02g0570700 LOC_Os02g36190 OsJ_07207 OSJNBa0008E01.37 P0689H05.7 Oryza sativa subsp. japonica (Rice) 518 diterpenoid biosynthetic process [GO:0016102]; oxidation-reduction process [GO:0055114]; secondary metabolite biosynthetic process [GO:0044550] GO:0005506; GO:0016020; GO:0016021; GO:0016102; GO:0016709; GO:0020037; GO:0044550; GO:0055114 0 0 0 PF00067; Q6ZRF8 CHOYP_LOC100373444.73.79 m.60857 sp RN207_HUMAN 22.162 185 122 7 29 206 114 283 2.63E-09 62.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_TVAG_127540.1.10 m.21803 sp RN207_HUMAN 21.078 204 147 6 23 224 103 294 2.63E-08 59.7 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7LHG5 CHOYP_YG31B.1.3 m.6174 sp YI31B_YEAST 29.017 1251 748 33 47 1250 311 1468 2.63E-125 428 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q7Z412 CHOYP_PEX26.1.1 m.27817 sp PEX26_HUMAN 33.058 121 79 1 57 175 50 170 2.63E-14 75.1 PEX26_HUMAN reviewed Peroxisome assembly protein 26 (Peroxin-26) PEX26 Homo sapiens (Human) 305 protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome membrane [GO:0045046] GO:0005777; GO:0005779; GO:0008022; GO:0016558; GO:0032403; GO:0045046; GO:0051117 0 0 0 PF07163; Q8IZT8 CHOYP_HS3S5.1.1 m.8536 sp HS3S5_HUMAN 50.896 279 129 1 90 368 76 346 2.63E-96 293 HS3S5_HUMAN reviewed Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5) HS3ST5 3OST5 HS3OST5 Homo sapiens (Human) 346 "glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]" GO:0000139; GO:0006024; GO:0006477; GO:0008467; GO:0015015; GO:0016021; GO:0046596; GO:0050656; GO:0050819 0 0 0 PF00685; Q8NEG5 CHOYP_LOC100371610.2.2 m.45179 sp ZSWM2_HUMAN 40.404 396 198 10 2 389 71 436 2.63E-92 306 ZSWM2_HUMAN reviewed E3 ubiquitin-protein ligase ZSWIM2 (EC 6.3.2.-) (MEKK1-related protein X) (MEX) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) ZSWIM2 ZZZ2 Homo sapiens (Human) 633 apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0006915; GO:0008270; GO:0016874; GO:0061630; GO:1902043 0 0 0 PF04434;PF13639;PF00569; Q8R0Z6 CHOYP_BRAFLDRAFT_252169.1.6 m.7998 sp ANGL6_MOUSE 41.111 180 91 5 5 176 281 453 2.63E-38 139 ANGL6_MOUSE reviewed Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) Angptl6 Agf Mus musculus (Mouse) 457 angiogenesis [GO:0001525]; cell differentiation [GO:0030154] GO:0001525; GO:0030141; GO:0030154; GO:0070062 0 0 0 PF00147; Q8R5C8 CHOYP_ZMY11.1.1 m.3621 sp ZMY11_MOUSE 37.405 655 352 10 1 650 1 602 2.63E-140 425 ZMY11_MOUSE reviewed Zinc finger MYND domain-containing protein 11 Zmynd11 Mus musculus (Mouse) 602 "covalent chromatin modification [GO:0016569]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of transcription elongation from RNA polymerase II promoter [GO:0034243]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0003682; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0006351; GO:0008270; GO:0016569; GO:0034243; GO:0035064; GO:0042393; GO:0043124; GO:0046329; GO:2001237 0 0 0 PF00439;PF00855; Q8VIJ6 CHOYP_SFPQ.1.1 m.15746 sp SFPQ_MOUSE 53.986 276 127 0 137 412 283 558 2.63E-99 317 SFPQ_MOUSE reviewed "Splicing factor, proline- and glutamine-rich (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)" Sfpq Psf Mus musculus (Mouse) 699 "alternative mRNA splicing, via spliceosome [GO:0000380]; cellular response to DNA damage stimulus [GO:0006974]; chromosome organization [GO:0051276]; double-strand break repair via homologous recombination [GO:0000724]; histone H3 deacetylation [GO:0070932]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of sister chromatid cohesion [GO:0045876]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0000380; GO:0000724; GO:0000785; GO:0000976; GO:0000980; GO:0001047; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006974; GO:0016363; GO:0042382; GO:0042752; GO:0042754; GO:0042826; GO:0044212; GO:0044822; GO:0045876; GO:0045892; GO:0048511; GO:0051276; GO:0051726; GO:0070932; GO:0090575; GO:1902177 0 0 0 PF08075;PF00076; Q8WPW2 CHOYP_NEMVEDRAFT_V1G194582.1.2 m.11442 sp PDX1_SUBDO 74.909 275 69 0 25 299 13 287 2.63E-153 435 PDX1_SUBDO reviewed Pyridoxal 5'-phosphate synthase subunit SNZERR (PLP synthase subunit SNZERR) (EC 4.3.3.6) (Ethylene response protein) (PDX1) SNZERR ERR Suberites domuncula (Sponge) 306 pyridoxal phosphate biosynthetic process [GO:0042823]; vitamin B6 biosynthetic process [GO:0042819] GO:0036381; GO:0042819; GO:0042823 PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. 0 cd04727; 0 Q92038 CHOYP_ACOD.1.8 m.3403 sp ACOD_CYPCA 66.977 215 70 1 2 215 109 323 2.63E-102 301 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; Q967D7 CHOYP_HMCN1.15.44 m.34725 sp TUTL_DROME 25.694 432 247 20 235 624 188 587 2.63E-10 69.3 TUTL_DROME reviewed Protein turtle tutl CG15427 Drosophila melanogaster (Fruit fly) 1531 adult locomotory behavior [GO:0008344]; axonal defasciculation [GO:0007414]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite self-avoidance [GO:0070593]; flight behavior [GO:0007629]; larval behavior [GO:0030537]; lateral inhibition [GO:0046331]; mechanosensory behavior [GO:0007638]; R7 cell development [GO:0045467]; regulation of dendrite morphogenesis [GO:0048814]; sensory perception of pain [GO:0019233]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007411; GO:0007414; GO:0007629; GO:0007638; GO:0008039; GO:0008344; GO:0016199; GO:0019233; GO:0030537; GO:0045467; GO:0046331; GO:0048814; GO:0070593; GO:0098632 0 0 0 PF00041;PF07679;PF07686; Q96HH6 CHOYP_TMM19.1.1 m.53705 sp TMM19_HUMAN 52.107 261 122 2 3 263 19 276 2.63E-91 276 TMM19_HUMAN reviewed Transmembrane protein 19 TMEM19 Homo sapiens (Human) 336 0 GO:0016021 0 0 0 PF01940; Q9DAN9 CHOYP_NEMVEDRAFT_V1G240545.1.3 m.49183 sp CQ105_MOUSE 36.429 140 88 1 16 155 23 161 2.63E-23 95.1 CQ105_MOUSE reviewed Uncharacterized protein C17orf105 homolog 0 Mus musculus (Mouse) 164 0 0 0 0 0 PF13879; Q9LQV2 CHOYP_BRAFLDRAFT_99723.7.9 m.59759 sp RDR1_ARATH 33.554 757 440 24 361 1078 372 1104 2.63E-98 347 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; Q9SKC3 CHOYP_NEMVEDRAFT_V1G244727.1.1 m.35118 sp ARI9_ARATH 31.111 225 122 10 566 783 127 325 2.63E-26 118 ARI9_ARATH reviewed Probable E3 ubiquitin-protein ligase ARI9 (EC 6.3.2.-) (ARIADNE-like protein ARI9) (Protein ariadne homolog 9) ARI9 At2g31770 F20M17.19 Arabidopsis thaliana (Mouse-ear cress) 543 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005737; GO:0008270; GO:0016874; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; Q9UA35 CHOYP_NEMVEDRAFT_V1G135437.2.2 m.27450 sp S28A3_EPTST 51.899 395 159 4 1 394 244 608 2.63E-135 405 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; Q9ULK2 CHOYP_AT7L1.1.1 m.35655 sp AT7L1_HUMAN 34.921 252 109 8 365 599 288 501 2.63E-25 116 AT7L1_HUMAN reviewed Ataxin-7-like protein 1 (Ataxin-7-like protein 4) ATXN7L1 ATXN7L4 KIAA1218 Homo sapiens (Human) 861 0 0 0 0 0 PF08313; Q9VCU9 CHOYP_DICER.1.3 m.9936 sp DCR1_DROME 50.613 571 225 8 424 974 1707 2240 2.63E-161 527 DCR1_DROME reviewed Endoribonuclease Dcr-1 (Protein dicer-1) (EC 3.1.26.-) Dcr-1 CG4792 Drosophila melanogaster (Fruit fly) 2249 "apoptotic DNA fragmentation [GO:0006309]; dendrite morphogenesis [GO:0048813]; dsRNA transport [GO:0033227]; germarium-derived female germ-line cyst formation [GO:0030727]; germarium-derived oocyte fate determination [GO:0007294]; germ-line stem cell division [GO:0042078]; mitotic cell cycle, embryonic [GO:0045448]; pole cell formation [GO:0007279]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; production of siRNA involved in RNA interference [GO:0030422]; response to starvation [GO:0042594]; RNA interference [GO:0016246]; segment polarity determination [GO:0007367]; siRNA loading onto RISC involved in RNA interference [GO:0035087]" GO:0003725; GO:0003727; GO:0004386; GO:0004525; GO:0004530; GO:0005524; GO:0005737; GO:0006309; GO:0007279; GO:0007294; GO:0007367; GO:0016246; GO:0016442; GO:0016443; GO:0030422; GO:0030727; GO:0031054; GO:0033227; GO:0035087; GO:0035196; GO:0042078; GO:0042594; GO:0045448; GO:0046872; GO:0048813; GO:0070883 0 0 cd00593; PF03368;PF00271;PF02170;PF00636; Q9VQG2 CHOYP_BRAFLDRAFT_123275.1.1 m.4993 sp APH1_DROME 56.574 251 95 3 15 265 1 237 2.63E-86 260 APH1_DROME reviewed Gamma-secretase subunit Aph-1 (Presenilin-stabilization factor) aph-1 PSF CG2855 Drosophila melanogaster (Fruit fly) 238 Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; protein processing [GO:0016485]; regulation of Notch signaling pathway [GO:0008593] GO:0004175; GO:0005770; GO:0005887; GO:0007219; GO:0008593; GO:0016485; GO:0043085; GO:0055037; GO:0070765 0 0 0 PF06105; Q9Y2C9 CHOYP_TLR1.3.3 m.60214 sp TLR6_HUMAN 23.182 440 298 18 175 597 352 768 2.63E-18 92.8 TLR6_HUMAN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) 796 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0038124; GO:0042088; GO:0042496; GO:0042742; GO:0043123; GO:0043507; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; Q9Y6R7 CHOYP_CYCMA_4407.2.4 m.20232 sp FCGBP_HUMAN 23.547 327 223 11 103 416 36 348 2.63E-12 73.6 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; Q9Z0R4 CHOYP_LOC100368708.1.1 m.44939 sp ITSN1_MOUSE 56.216 185 81 0 47 231 1216 1400 2.63E-68 230 ITSN1_MOUSE reviewed Intersectin-1 (EH and SH3 domains protein 1) Itsn1 Ese1 Itsn Mus musculus (Mouse) 1714 endocytosis [GO:0006897]; ephrin receptor signaling pathway [GO:0048013]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264] GO:0005089; GO:0005509; GO:0005829; GO:0005886; GO:0005905; GO:0006897; GO:0007264; GO:0019209; GO:0030027; GO:0030054; GO:0030139; GO:0032947; GO:0035023; GO:0043005; GO:0043524; GO:0045202; GO:0048013; GO:0051897; GO:0070064 0 0 0 PF00168;PF12763;PF16652;PF00621;PF00018;PF14604; A4IF63 CHOYP_BRAFLDRAFT_241726.15.22 m.33099 sp TRIM2_BOVIN 23.786 206 150 3 2 202 541 744 2.64E-07 53.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; C3YWU0 CHOYP_LOC660225.1.1 m.35196 sp FUCO_BRAFL 50.463 432 208 5 27 455 17 445 2.64E-161 466 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; E9Q555 CHOYP_BRAFLDRAFT_108419.1.3 m.18368 sp RN213_MOUSE 45.559 349 163 5 48 379 2909 3247 2.64E-86 289 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O00602 CHOYP_BRAFLDRAFT_88596.2.2 m.37631 sp FCN1_HUMAN 48.108 185 89 3 303 483 144 325 2.64E-48 172 FCN1_HUMAN reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) FCN1 FCNM Homo sapiens (Human) 326 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of interleukin-8 secretion [GO:2000484]; protein localization to cell surface [GO:0034394]; recognition of apoptotic cell [GO:0043654]" GO:0001664; GO:0001867; GO:0002752; GO:0004252; GO:0005576; GO:0005581; GO:0006956; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0033691; GO:0034394; GO:0043654; GO:0046597; GO:0046872; GO:2000484 0 0 0 PF01391;PF00147; O42976 CHOYP_LOC101163257.1.1 m.58647 sp YGZ7_SCHPO 40.171 117 69 1 23 138 199 315 2.64E-25 112 YGZ7_SCHPO reviewed Uncharacterized membrane protein C20F10.07 SPBC20F10.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 764 0 GO:0005737; GO:0016021 0 0 0 PF16016;PF02893; O43826 CHOYP_SLC37A4.1.1 m.53720 sp G6PT1_HUMAN 39.231 390 232 2 8 394 10 397 2.64E-88 278 G6PT1_HUMAN reviewed Glucose-6-phosphate exchanger SLC37A4 (Glucose-5-phosphate transporter) (Glucose-6-phosphate translocase) (Solute carrier family 37 member 4) (Transformation-related gene 19 protein) (TRG-19) SLC37A4 G6PT G6PT1 PRO0685 TRG19 Homo sapiens (Human) 429 glucose-6-phosphate transport [GO:0015760]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glucose transport [GO:0015758]; mitophagy in response to mitochondrial depolarization [GO:0098779]; phosphate ion transmembrane transport [GO:0035435]; positive regulation of defense response to virus by host [GO:0002230]; transport [GO:0006810]; xenophagy [GO:0098792] GO:0002230; GO:0005215; GO:0005783; GO:0005789; GO:0006006; GO:0006810; GO:0015152; GO:0015758; GO:0015760; GO:0016020; GO:0016021; GO:0030176; GO:0035435; GO:0042593; GO:0061513; GO:0098779; GO:0098792 0 0 cd06174; PF07690; O88307 CHOYP_UNC52.1.1 m.52711 sp SORL_MOUSE 49.606 127 60 3 99 221 1078 1204 2.64E-29 123 SORL_MOUSE reviewed Sortilin-related receptor (Gp250) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) Sorl1 Mus musculus (Mouse) 2215 cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897]; lipid transport [GO:0006869]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of beta-amyloid formation [GO:1902430]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein oligomerization [GO:0032460]; negative regulation of tau-protein kinase activity [GO:1902948]; positive regulation of choline O-acetyltransferase activity [GO:1902771]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to Golgi [GO:0000042]; protein targeting to lysosome [GO:0006622]; regulation of smooth muscle cell migration [GO:0014910] GO:0000042; GO:0001540; GO:0005615; GO:0005641; GO:0005768; GO:0005769; GO:0005783; GO:0005794; GO:0005802; GO:0006605; GO:0006622; GO:0006869; GO:0006892; GO:0006897; GO:0008203; GO:0014910; GO:0016020; GO:0016021; GO:0030169; GO:0030306; GO:0031985; GO:0032091; GO:0032460; GO:0034362; GO:0043407; GO:0045053; GO:0045732; GO:0048471; GO:0050768; GO:0051604; GO:0055037; GO:0070062; GO:0070863; GO:1901215; GO:1902430; GO:1902771; GO:1902948; GO:1902953; GO:1902955; GO:1902960; GO:1902963; GO:1902966; GO:1902997; GO:2001137 0 0 0 PF00041;PF00057;PF00058;PF15902;PF15901; O93530 CHOYP_BRAFLDRAFT_72852.1.2 m.36453 sp WRN_XENLA 28.777 417 236 15 2 387 502 888 2.64E-36 144 WRN_XENLA reviewed Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-) (Focus-forming activity 1) (FFA-1) wrn ffa1 Xenopus laevis (African clawed frog) 1436 DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] GO:0000287; GO:0003677; GO:0005524; GO:0005634; GO:0006259; GO:0006260; GO:0006281; GO:0006310; GO:0008408; GO:0030145; GO:0043140 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; P0C218 CHOYP_DDX20.2.3 m.17436 sp DDX20_DANRE 64.111 287 99 1 2 284 3 289 2.64E-128 387 DDX20_DANRE reviewed Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (DEAD box protein 20) ddx20 Danio rerio (Zebrafish) (Brachydanio rerio) 761 RNA secondary structure unwinding [GO:0010501]; spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0003677; GO:0004004; GO:0005524; GO:0005634; GO:0005829; GO:0010501; GO:0032797; GO:0034719 0 0 0 PF00270;PF00271; P50554 CHOYP_LOC656992.2.3 m.29928 sp GABT_RAT 49.462 465 235 0 24 488 28 492 2.64E-170 492 GABT_RAT reviewed "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) [Cleaved into: 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform]" Abat Gabat Rattus norvegicus (Rat) 500 aging [GO:0007568]; behavioral response to cocaine [GO:0048148]; cerebellum development [GO:0021549]; copulation [GO:0007620]; exploration behavior [GO:0035640]; gamma-aminobutyric acid biosynthetic process [GO:0009449]; gamma-aminobutyric acid catabolic process [GO:0009450]; locomotory behavior [GO:0007626]; negative regulation of blood pressure [GO:0045776]; negative regulation of dopamine secretion [GO:0033602]; negative regulation of gamma-aminobutyric acid secretion [GO:0014053]; negative regulation of platelet aggregation [GO:0090331]; neurotransmitter catabolic process [GO:0042135]; positive regulation of aspartate secretion [GO:1904450]; positive regulation of dopamine metabolic process [GO:0045964]; positive regulation of heat generation [GO:0031652]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of prolactin secretion [GO:1902722]; positive regulation of uterine smooth muscle contraction [GO:0070474]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to nicotine [GO:0035094] GO:0001666; GO:0003867; GO:0005739; GO:0005759; GO:0007568; GO:0007620; GO:0007626; GO:0009449; GO:0009450; GO:0010039; GO:0014053; GO:0021549; GO:0030170; GO:0031652; GO:0032024; GO:0032144; GO:0032145; GO:0033602; GO:0035094; GO:0035640; GO:0042135; GO:0042220; GO:0042493; GO:0042802; GO:0042803; GO:0043005; GO:0045471; GO:0045776; GO:0045964; GO:0046872; GO:0047298; GO:0048148; GO:0051536; GO:0070062; GO:0070474; GO:0090331; GO:0097151; GO:1902722; GO:1904450 0 0 cd00610; PF00202; P51955 CHOYP_NEK2.1.3 m.17590 sp NEK2_HUMAN 58.708 356 133 3 14 356 1 355 2.64E-149 434 NEK2_HUMAN reviewed Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) NEK2 NEK2A NLK1 Homo sapiens (Human) 445 blastocyst development [GO:0001824]; cell division [GO:0051301]; centrosome separation [GO:0051299]; chromosome segregation [GO:0007059]; G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; negative regulation of centriole-centriole cohesion [GO:1903126]; negative regulation of DNA binding [GO:0043392]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225] GO:0000070; GO:0000086; GO:0000776; GO:0000777; GO:0000794; GO:0000922; GO:0001824; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0005813; GO:0005829; GO:0005874; GO:0006468; GO:0007059; GO:0007067; GO:0007088; GO:0019903; GO:0030496; GO:0032212; GO:0043234; GO:0043392; GO:0046602; GO:0046777; GO:0046872; GO:0051225; GO:0051299; GO:0051301; GO:0051321; GO:0051973; GO:0051988; GO:0090307; GO:1903126; GO:1904355 0 0 0 PF00069; P68143 CHOYP_ACT2.1.3 m.10934 sp ACTB_OREMO 98.148 108 2 0 1 108 227 334 2.64E-72 222 ACTB_OREMO reviewed "Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]" actb Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica) 375 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; P77735 CHOYP_LOC587705.1.2 m.11702 sp YAJO_ECOLI 39.118 340 178 9 37 368 1 319 2.64E-62 206 YAJO_ECOLI reviewed Uncharacterized oxidoreductase YajO (EC 1.-.-.-) yajO b0419 JW0409 Escherichia coli (strain K12) 324 thiamine metabolic process [GO:0006772] GO:0005829; GO:0006772; GO:0016491 0 0 cd06660; PF00248; P81134 CHOYP_BRAFLDRAFT_280496.1.1 m.27628 sp RENR_BOVIN 31.268 355 236 4 16 366 1 351 2.64E-60 201 RENR_BOVIN reviewed Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (V-ATPase M8.9 subunit) ATP6AP2 ATP6IP2 Bos taurus (Bovine) 351 0 GO:0004872; GO:0016021 0 0 0 PF07850; P86854 CHOYP_NEMVEDRAFT_V1G238062.4.6 m.29849 sp PLCL_MYTGA 30 160 96 4 11 163 6 156 2.64E-22 90.9 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q01538 CHOYP_LOC101167938.1.1 m.27316 sp MYT1_HUMAN 48.78 205 67 5 183 381 439 611 2.64E-50 188 MYT1_HUMAN reviewed Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1 Homo sapiens (Human) 1121 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0007399; GO:0008270; GO:0030154 0 0 0 PF08474;PF01530; Q01887 CHOYP_LOC100703289.1.1 m.53586 sp RYK_MOUSE 41.876 597 283 10 23 605 48 594 2.64E-159 472 RYK_MOUSE reviewed Tyrosine-protein kinase RYK (EC 2.7.10.1) (Kinase VIK) (Met-related kinase) (NYK-R) Ryk Mrk Mus musculus (Mouse) 594 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; chemorepulsion of axon [GO:0061643]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative chemotaxis [GO:0050919]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; planar cell polarity pathway involved in axon guidance [GO:1904938]; positive regulation of MAPK cascade [GO:0043410]; skeletal system morphogenesis [GO:0048705]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953] GO:0004672; GO:0004888; GO:0005109; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0007409; GO:0007411; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0022038; GO:0030182; GO:0031175; GO:0036518; GO:0042813; GO:0043410; GO:0048705; GO:0048843; GO:0050919; GO:0061643; GO:0071679; GO:1904938; GO:1904948; GO:1904953 0 0 0 PF07714;PF02019; Q14980 CHOYP_LOC100377654.1.1 m.19764 sp NUMA1_HUMAN 58.974 39 15 1 486 523 1904 1942 2.64E-08 60.8 NUMA1_HUMAN reviewed Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) 2115 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997] GO:0000132; GO:0000139; GO:0000922; GO:0005198; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005876; GO:0005938; GO:0006997; GO:0007067; GO:0016363; GO:0030425; GO:0043025; GO:0045177; GO:0051301; GO:0051321; GO:0060487; GO:0061673; GO:0070062; GO:0072686; GO:0097431 0 0 0 0 Q29RZ4 CHOYP_ZNF91.4.4 m.12293 sp ZNF2_BOVIN 32.883 222 114 5 582 781 186 394 2.64E-23 107 ZNF2_BOVIN reviewed Zinc finger protein 2 ZNF2 Bos taurus (Bovine) 425 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13465; Q3TLP5 CHOYP_AUHM.2.2 m.44102 sp ECHD2_MOUSE 54.887 266 120 0 69 334 30 295 2.64E-100 300 ECHD2_MOUSE reviewed "Enoyl-CoA hydratase domain-containing protein 2, mitochondrial" Echdc2 D4Ertd765e Mus musculus (Mouse) 296 fatty acid beta-oxidation [GO:0006635] GO:0004300; GO:0005739; GO:0006635 0 0 0 PF00378; Q5ND28 CHOYP_MEG11.14.25 m.46434 sp SREC_MOUSE 35.955 178 106 6 36 213 247 416 2.64E-20 93.2 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RJ80 CHOYP_LOC101165018.1.5 m.161 sp CAPR2_DANRE 32.727 165 84 6 233 379 756 911 2.64E-11 68.9 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5VU97 CHOYP_CAHD1.5.6 m.53893 sp CAHD1_HUMAN 26.031 849 558 33 2 802 237 1063 2.64E-63 236 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6UXB8 CHOYP_GLIPR1.3.3 m.30841 sp PI16_HUMAN 34.706 170 92 7 48 206 36 197 2.64E-20 97.8 PI16_HUMAN reviewed Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 Homo sapiens (Human) 463 0 GO:0016021; GO:0030414; GO:0070062 0 0 0 PF00188; Q6V0I7 CHOYP_LOC100377212.1.1 m.20023 sp FAT4_HUMAN 26.93 1140 723 44 751 1837 2034 3116 2.64E-62 241 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q8VIK5 CHOYP_MEGF6.41.59 m.46752 sp PEAR1_MOUSE 37.004 227 128 9 107 332 480 692 2.64E-31 130 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q921J2 CHOYP_LOC100533537.1.1 m.36 sp RHEB_MOUSE 59.341 182 72 2 1 181 1 181 2.64E-77 231 RHEB_MOUSE reviewed GTP-binding protein Rheb (Ras homolog enriched in brain) Rheb Mus musculus (Mouse) 184 positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of TOR signaling [GO:0032008]; regulation of TOR signaling [GO:0032006]; regulation of type B pancreatic cell development [GO:2000074]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0005525; GO:0005681; GO:0005789; GO:0005829; GO:0007264; GO:0019901; GO:0032006; GO:0032008; GO:0046872; GO:0048714; GO:0070062; GO:2000074 0 0 0 PF00071; Q98943 CHOYP_BRAFLDRAFT_129004.6.15 m.34881 sp CASP2_CHICK 30.556 108 75 0 240 347 3 110 2.64E-08 60.5 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9BWL3 CHOYP_CA043.1.1 m.61477 sp CA043_HUMAN 37.629 194 89 7 7 178 8 191 2.64E-25 103 CA043_HUMAN reviewed Uncharacterized protein C1orf43 (Hepatitis C virus NS5A-transactivated protein 4) (HCV NS5A-transactivated protein 4) (Protein NICE-3) (S863-3) C1orf43 NICE3 NS5ATP4 HSPC012 Homo sapiens (Human) 253 0 GO:0016021; GO:0016491 0 0 0 PF07406; Q9DC58 CHOYP_NEMVEDRAFT_V1G123078.1.1 m.54650 sp DRAM1_MOUSE 30.488 246 142 6 8 246 3 226 2.64E-19 87.8 DRAM1_MOUSE reviewed DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) Dram1 Dram Mus musculus (Mouse) 238 apoptotic process [GO:0006915]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506] GO:0005737; GO:0005764; GO:0005765; GO:0006914; GO:0006915; GO:0010506; GO:0016021 0 0 0 PF10277; Q9DG68 CHOYP_LOC100370010.5.5 m.40352 sp RLA0_RANSY 71.273 275 79 0 1 275 1 275 2.64E-147 419 RLA0_RANSY reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) 315 ribosome biogenesis [GO:0042254] GO:0005840; GO:0042254 0 0 0 PF00466; Q9ESN6 CHOYP_LOC100373444.39.79 m.34938 sp TRIM2_MOUSE 28.571 224 137 10 138 356 536 741 2.64E-11 68.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9P2E3 CHOYP_LOC663650.1.1 m.20065 sp ZNFX1_HUMAN 37.569 181 105 4 61 241 1734 1906 2.64E-32 127 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9QYI4 CHOYP_BRAFLDRAFT_209304.2.2 m.63768 sp DJB12_MOUSE 45.55 382 178 8 19 380 1 372 2.64E-108 325 DJB12_MOUSE reviewed DnaJ homolog subfamily B member 12 (mDj10) Dnajb12 Mus musculus (Mouse) 376 0 GO:0016020; GO:0016021 0 0 cd06257; PF00226;PF09320; Q9QZB9 CHOYP_LOC752555.1.1 m.4461 sp DCTN5_MOUSE 82.386 176 31 0 1 176 1 176 2.64E-109 313 DCTN5_MOUSE reviewed Dynactin subunit 5 (Dynactin subunit p25) Dctn5 Mus musculus (Mouse) 182 aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; ventricular septum development [GO:0003281] GO:0000777; GO:0003281; GO:0005654; GO:0005737; GO:0005813; GO:0031965; GO:0035904; GO:0060976 0 0 0 PF00132; Q9WVH0 CHOYP_RS13.1.5 m.16029 sp RS13_CRIGR 82.407 108 19 0 9 116 43 150 2.64E-62 189 RS13_CRIGR reviewed 40S ribosomal protein S13 RPS13 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 151 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00353; PF08069;PF00312; Q9WVK3 CHOYP_PECR.1.1 m.58859 sp PECR_RAT 55.474 274 119 2 24 295 9 281 2.64E-107 317 PECR_RAT reviewed "Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (PX-2,4-DCR1) (Peroxisomal 2,4-dienoyl-CoA reductase) (RLF98)" Pecr Rattus norvegicus (Rat) 303 fatty acid biosynthetic process [GO:0006633]; oxidation-reduction process [GO:0055114]; phytol metabolic process [GO:0033306] GO:0005739; GO:0005777; GO:0005778; GO:0006633; GO:0019166; GO:0033306; GO:0043231; GO:0055114 PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 0 Q9Y6J0 CHOYP_CABIN1.1.1 m.15905 sp CABIN_HUMAN 40.428 935 499 21 512 1408 391 1305 2.64E-180 614 CABIN_HUMAN reviewed Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) CABIN1 KIAA0330 Homo sapiens (Human) 2220 cell surface receptor signaling pathway [GO:0007166]; covalent chromatin modification [GO:0016569]; DNA replication-independent nucleosome assembly [GO:0006336]; negative regulation of cell death [GO:0060548]; response to activity [GO:0014823] GO:0004864; GO:0005634; GO:0005654; GO:0005737; GO:0006336; GO:0007166; GO:0014823; GO:0016235; GO:0016569; GO:0060548 0 0 cd13839; PF09047; A0JM12 CHOYP_MEG10.21.91 m.25805 sp MEG10_XENTR 38.739 222 122 9 204 425 142 349 2.65E-28 121 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A7LCJ2 CHOYP_LOC100893270.1.3 m.15658 sp PA2_URTCR 36.752 117 68 4 17 130 31 144 2.65E-17 76.3 PA2_URTCR reviewed Phospholipase A2 A2-actitoxin-Ucs2a (A2-AITX-Ucs2a) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (UcPLA2) 0 Urticina crassicornis (Mottled anemone) (Tealia crassicornis) 155 lipid catabolic process [GO:0016042] GO:0004623; GO:0005509; GO:0005576; GO:0016042; GO:0042151 0 0 0 PF00068; E9Q349 CHOYP_LOC100022509.1.1 m.18000 sp WDR25_MOUSE 37.69 329 194 8 185 509 212 533 2.65E-69 234 WDR25_MOUSE reviewed WD repeat-containing protein 25 Wdr25 Mus musculus (Mouse) 535 0 0 0 0 0 PF00400; F7H9X2 CHOYP_BRAFLDRAFT_205965.7.43 m.17213 sp TRIM2_CALJA 23.776 143 104 3 94 232 602 743 2.65E-06 51.6 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_LOC754047.1.3 m.38988 sp ANR17_HUMAN 30.568 458 240 16 190 634 236 628 2.65E-32 140 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P04183 CHOYP_LOC100368622.1.1 m.24511 sp KITH_HUMAN 62.319 207 76 2 145 350 17 222 2.65E-84 258 KITH_HUMAN reviewed "Thymidine kinase, cytosolic (EC 2.7.1.21)" TK1 Homo sapiens (Human) 234 digestive tract development [GO:0048565]; DNA biosynthetic process [GO:0071897]; DNA metabolic process [GO:0006259]; fetal process involved in parturition [GO:0060138]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; protein homotetramerization [GO:0051289]; pyrimidine nucleoside salvage [GO:0043097]; response to copper ion [GO:0046688]; response to cortisol [GO:0051414]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636]; skeletal muscle cell proliferation [GO:0014856]; thymidine metabolic process [GO:0046104] GO:0001889; GO:0004797; GO:0005524; GO:0005829; GO:0006139; GO:0006259; GO:0008270; GO:0009636; GO:0014856; GO:0019206; GO:0031667; GO:0042802; GO:0043097; GO:0046104; GO:0046688; GO:0048565; GO:0051289; GO:0051414; GO:0060138; GO:0071897 0 0 0 PF00265; P08021 CHOYP_FMRF.3.4 m.47754 sp FMRF_APLCA 56.742 356 61 21 2 305 133 447 2.65E-71 234 FMRF_APLCA reviewed FMRF-amide neuropeptides [Cleaved into: FLRF-amide; FMRF-amide] 0 Aplysia californica (California sea hare) 597 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF01581; P15056 CHOYP_BRAF.1.3 m.6010 sp BRAF_HUMAN 41.228 342 125 8 1 277 205 535 2.65E-65 220 BRAF_HUMAN reviewed Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF BRAF1 RAFB1 Homo sapiens (Human) 766 "CD4-positive, alpha-beta T cell differentiation [GO:0043367]; cellular response to calcium ion [GO:0071277]; cellular response to drug [GO:0035690]; establishment of protein localization to membrane [GO:0090150]; face development [GO:0060324]; glucose transport [GO:0015758]; head morphogenesis [GO:0060323]; long-term synaptic potentiation [GO:0060291]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; organ morphogenesis [GO:0009887]; positive regulation of axonogenesis [GO:0050772]; positive regulation of axon regeneration [GO:0048680]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive T cell selection [GO:0043368]; protein heterooligomerization [GO:0051291]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; response to cAMP [GO:0051591]; response to peptide hormone [GO:0043434]; somatic stem cell population maintenance [GO:0035019]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; visual learning [GO:0008542]" GO:0000165; GO:0002318; GO:0004672; GO:0004674; GO:0004709; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006468; GO:0008542; GO:0009887; GO:0010628; GO:0010764; GO:0015758; GO:0030878; GO:0033138; GO:0035019; GO:0035690; GO:0042127; GO:0042802; GO:0043005; GO:0043066; GO:0043231; GO:0043367; GO:0043368; GO:0043434; GO:0043524; GO:0044297; GO:0048538; GO:0048680; GO:0050772; GO:0051291; GO:0051496; GO:0051591; GO:0060291; GO:0060323; GO:0060324; GO:0070374; GO:0071277; GO:0090150; GO:1900026; GO:2000301; GO:2000352 0 0 0 PF00130;PF07714;PF02196; P35559 CHOYP_IDE.3.3 m.67035 sp IDE_RAT 56.597 288 124 1 3 290 43 329 2.65E-109 347 IDE_RAT reviewed Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) Ide Rattus norvegicus (Rat) 1019 beta-amyloid metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular protein catabolic process [GO:0044257]; determination of adult lifespan [GO:0008340]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; negative regulation of proteolysis [GO:0045861]; peptide catabolic process [GO:0043171]; positive regulation of protein oligomerization [GO:0032461]; protein heterooligomerization [GO:0051291]; protein homotetramerization [GO:0051289]; protein processing [GO:0016485]; proteolysis involved in cellular protein catabolic process [GO:0051603]; ubiquitin homeostasis [GO:0010992] GO:0001540; GO:0001948; GO:0004222; GO:0005524; GO:0005615; GO:0005634; GO:0005654; GO:0005739; GO:0005782; GO:0005829; GO:0005886; GO:0008233; GO:0008270; GO:0008340; GO:0009986; GO:0010815; GO:0010992; GO:0016485; GO:0016887; GO:0017046; GO:0031597; GO:0031626; GO:0032461; GO:0042447; GO:0042803; GO:0043171; GO:0043559; GO:0044257; GO:0045861; GO:0050435; GO:0051289; GO:0051291; GO:0051603; GO:1901143 0 0 0 PF00675;PF05193;PF16187; P62755 CHOYP_RS6.7.12 m.34911 sp RS6_RAT 86.014 143 20 0 1 143 1 143 2.65E-91 268 RS6_RAT reviewed 40S ribosomal protein S6 Rps6 Rattus norvegicus (Rat) 249 cellular response to ethanol [GO:0071361]; glucose homeostasis [GO:0042593]; negative regulation of bicellular tight junction assembly [GO:1903347]; response to insulin [GO:0032868]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0000028; GO:0003729; GO:0003735; GO:0006364; GO:0006412; GO:0022627; GO:0032868; GO:0042593; GO:0071361; GO:1903347 0 0 0 PF01092; P82928 CHOYP_MRPS28.1.1 m.29259 sp RT28_BOVIN 38.125 160 76 4 33 191 51 188 2.65E-24 97.4 RT28_BOVIN reviewed "28S ribosomal protein S28, mitochondrial (MRP-S28) (S28mt)" MRPS28 Bos taurus (Bovine) 189 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0005743; GO:0005763; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF10246; Q2NL00 CHOYP_BRAFLDRAFT_123804.1.1 m.4541 sp GSTT1_BOVIN 39.056 233 137 4 27 256 1 231 2.65E-54 178 GSTT1_BOVIN reviewed Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) GSTT1 Bos taurus (Bovine) 240 glutathione metabolic process [GO:0006749] GO:0004364; GO:0005737; GO:0006749 0 0 0 PF00043;PF02798; Q3HNM7 CHOYP_BRAFLDRAFT_74076.1.1 m.7696 sp INSC_MOUSE 37.573 511 305 6 22 522 73 579 2.65E-100 317 INSC_MOUSE reviewed Protein inscuteable homolog (Minsc) Insc Mus musculus (Mouse) 579 establishment of mitotic spindle orientation [GO:0000132]; lung epithelial cell differentiation [GO:0060487]; nervous system development [GO:0007399] GO:0000132; GO:0005938; GO:0007399; GO:0045177; GO:0060487 0 0 0 PF16748; Q3SWT4 CHOYP_IWS1.1.1 m.13972 sp IWS1_RAT 51.671 389 161 4 351 736 400 764 2.65E-121 384 IWS1_RAT reviewed Protein IWS1 homolog (IWS1-like protein) Iws1 Iws1l Rattus norvegicus (Rat) 764 "mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; regulation of histone H3-K36 trimethylation [GO:2001253]; regulation of histone H4 acetylation [GO:0090239]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0010793; GO:0050684; GO:0051028; GO:0090239; GO:2001253 0 0 0 PF08711; Q5RF96 CHOYP_BRAFLDRAFT_127523.1.1 m.56004 sp SPCS1_PONAB 52.874 87 41 0 9 95 3 89 2.65E-31 109 SPCS1_PONAB reviewed Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) SPCS1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 102 signal peptide processing [GO:0006465] GO:0005787; GO:0006465; GO:0008233; GO:0016021; GO:0031090 0 0 0 PF06645; Q5RFS1 CHOYP_LOC100085158.1.1 m.240 sp ASB11_PONAB 28.185 259 164 7 14 260 72 320 2.65E-14 75.1 ASB11_PONAB reviewed Ankyrin repeat and SOCS box protein 11 (ASB-11) ASB11 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 323 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q6DFV8 CHOYP_NEMVEDRAFT_V1G214844.20.34 m.44765 sp VWDE_MOUSE 24.066 482 311 24 51 503 60 515 2.65E-11 71.6 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6PFY8 CHOYP_LOC100486775.1.1 m.32166 sp TRI45_MOUSE 19.934 301 212 8 13 293 135 426 2.65E-07 55.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7G0 CHOYP_Y068.1.6 m.6689 sp Y068_OSHVF 24.034 466 309 8 86 512 155 614 2.65E-36 146 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q8BYH3 CHOYP_TRM13.1.1 m.16853 sp TRM13_MOUSE 33.524 525 260 9 21 528 16 468 2.65E-89 285 TRM13_MOUSE reviewed tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76) Trmt13 Ccdc76 Mus musculus (Mouse) 481 tRNA methylation [GO:0030488] GO:0008175; GO:0030488; GO:0046872 0 0 0 PF05206;PF11722;PF05253; Q8CDF7 CHOYP_ISCW_ISCW022591.1.1 m.25413 sp EXD1_MOUSE 46.739 92 46 3 29 119 155 244 2.65E-12 72.4 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q96LY2 CHOYP_LOC100377585.3.3 m.63265 sp CC74B_HUMAN 53.448 58 27 0 49 106 41 98 2.65E-10 64.7 CC74B_HUMAN reviewed Coiled-coil domain-containing protein 74B CCDC74B Homo sapiens (Human) 380 0 0 0 0 0 PF14917; Q9BWH6 CHOYP_RPAP1.2.4 m.40002 sp RPAP1_HUMAN 37.956 411 237 8 27 430 976 1375 2.65E-75 259 RPAP1_HUMAN reviewed RNA polymerase II-associated protein 1 RPAP1 KIAA1403 Homo sapiens (Human) 1393 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0006366 0 0 0 PF08620;PF08621; Q9CQZ5 CHOYP_LOC101070737.1.3 m.1746 sp NDUA6_MOUSE 53.608 97 45 0 21 117 21 117 2.65E-31 110 NDUA6_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (NADH-ubiquinone oxidoreductase B14 subunit) Ndufa6 Mus musculus (Mouse) 131 oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005747; GO:0006979; GO:0031966; GO:0055114 0 0 0 PF05347; Q9JJT0 CHOYP_RCL1.1.1 m.7474 sp RCL1_MOUSE 65.84 363 117 3 7 368 8 364 2.65E-172 487 RCL1_MOUSE reviewed RNA 3'-terminal phosphate cyclase-like protein Rcl1 Rnac Mus musculus (Mouse) 373 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; rRNA processing [GO:0006364]" GO:0000447; GO:0000480; GO:0003723; GO:0004521; GO:0005730; GO:0006364 0 0 cd00875; PF01137;PF05189; Q9SQK3 CHOYP_LOC581491.1.2 m.56127 sp EM506_ARATH 43.243 74 41 1 93 166 165 237 2.65E-10 61.2 EM506_ARATH reviewed "Ankyrin repeat domain-containing protein EMB506, chloroplastic (Protein EMBRYO DEFECTIVE 506)" EMB506 At5g40160 MSN9.60 Arabidopsis thaliana (Mouse-ear cress) 315 0 GO:0009507 0 0 0 PF12796; Q9U3W6 CHOYP_NEMVEDRAFT_V1G199927.9.9 m.55338 sp MAB21_DROME 23.171 164 114 3 155 312 186 343 2.65E-06 52.8 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; Q9Y6Y1 CHOYP_CMTA1.2.2 m.42751 sp CMTA1_HUMAN 42.471 259 122 11 412 663 1391 1629 2.65E-40 166 CMTA1_HUMAN reviewed Calmodulin-binding transcription activator 1 CAMTA1 KIAA0833 MSTP023 Homo sapiens (Human) 1673 neuromuscular process controlling balance [GO:0050885]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001077; GO:0005634; GO:0005737; GO:0043565; GO:0045944; GO:0050885 0 0 0 PF03859;PF00612;PF01833; A3RLT6 CHOYP_CUL3B.1.1 m.61644 sp RSSA_PINFU 83.959 293 42 5 34 324 1 290 2.66E-166 468 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A4QP81 CHOYP_FRRS1.3.3 m.43299 sp FRRS1_DANRE 35.119 168 93 7 6 169 11 166 2.66E-16 80.1 FRRS1_DANRE reviewed Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 zgc:163022 Danio rerio (Zebrafish) (Brachydanio rerio) 573 0 GO:0016021; GO:0016491 0 0 cd08544; PF03351;PF02014; A6BM72 CHOYP_BRAFLDRAFT_224574.15.18 m.50768 sp MEG11_HUMAN 38.411 302 163 14 7 303 240 523 2.66E-40 153 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; B0BN95 CHOYP_LOC101240925.1.1 m.24271 sp HARB1_RAT 36.842 228 141 2 33 260 27 251 2.66E-42 150 HARB1_RAT reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Rattus norvegicus (Rat) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; B5DF93 CHOYP_BRAFLDRAFT_119484.3.3 m.66434 sp PATL1_RAT 38.947 380 204 11 547 910 399 766 2.66E-59 220 PATL1_RAT reviewed Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) Patl1 Rattus norvegicus (Rat) 770 cytoplasmic mRNA processing body assembly [GO:0033962]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290] GO:0000290; GO:0000932; GO:0003723; GO:0008266; GO:0016605; GO:0016607; GO:0030014; GO:0033962; GO:0034046; GO:0044822 0 0 0 PF09770; O15117 CHOYP_contig_017721 m.20744 sp FYB_HUMAN 50.98 51 24 1 32 82 521 570 2.66E-10 58.5 FYB_HUMAN reviewed FYN-binding protein (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) FYB SLAP130 Homo sapiens (Human) 783 immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; NLS-bearing protein import into nucleus [GO:0006607]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852] GO:0005102; GO:0005634; GO:0005829; GO:0005886; GO:0006468; GO:0006607; GO:0006955; GO:0007165; GO:0015629; GO:0030054; GO:0035556; GO:0050852; GO:0072659 0 0 0 PF14603;PF07653; O88696 CHOYP_NEMVEDRAFT_V1G192713.1.1 m.16224 sp CLPP_MOUSE 64.021 189 68 0 24 212 52 240 2.66E-89 267 CLPP_MOUSE reviewed "ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp)" Clpp Mus musculus (Mouse) 272 misfolded or incompletely synthesized protein catabolic process [GO:0006515]; protein homooligomerization [GO:0051260]; proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004252; GO:0005739; GO:0005759; GO:0006515; GO:0009368; GO:0051260; GO:0051603 0 0 0 PF00574; P13418 CHOYP_RSRNAV_ORF-2.1.1 m.4518 sp POLS_CRPVC 23.412 803 491 26 10 725 63 828 2.66E-29 129 POLS_CRPVC reviewed Structural polyprotein [Cleaved into: Capsid protein 1 (CP1); Capsid protein 4 (CP4); Capsid protein 2 (CP2); Capsid protein 3 (CP3)] 0 Cricket paralysis virus (isolate Teleogryllus commodus/Australia/CrPVVIC/1968) (CrPV) 895 0 GO:0005198; GO:0019028; GO:0030430 0 0 cd00205; PF08762;PF11492;PF00073; P13608 CHOYP_NEMVEDRAFT_V1G210164.1.1 m.60943 sp PGCA_BOVIN 32.593 135 73 6 114 243 2158 2279 2.66E-14 75.5 PGCA_BOVIN reviewed Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) 2364 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005576; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; P20007 CHOYP_PCK1.1.1 m.15798 sp PCKG_DROME 56.391 133 58 0 41 173 40 172 2.66E-49 171 PCKG_DROME reviewed Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) Pepck ZDF4 CG17725 Drosophila melanogaster (Fruit fly) 647 gluconeogenesis [GO:0006094] GO:0004613; GO:0005525; GO:0006094; GO:0046872 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. 0 0 PF00821; P22105 CHOYP_LOC579946.6.24 m.39530 sp TENX_HUMAN 30.13 385 178 31 9 334 328 680 2.66E-25 111 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P36241 CHOYP_LOC100377332.2.2 m.47444 sp RL19_DROME 59.036 83 33 1 8 90 85 166 2.66E-24 95.1 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P54145 CHOYP_NEMVEDRAFT_V1G173932.2.3 m.37158 sp AMT1_CAEEL 34.038 426 248 7 17 410 41 465 2.66E-61 211 AMT1_CAEEL reviewed Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans 534 ammonium transmembrane transport [GO:0072488]; nitrogen utilization [GO:0019740]; organic cation transport [GO:0015695] GO:0005887; GO:0008519; GO:0015695; GO:0019740; GO:0072488 0 0 0 PF00909; P56558 CHOYP_OGT1.2.3 m.50803 sp OGT1_RAT 85.976 164 23 0 3 166 4 167 2.66E-95 301 OGT1_RAT reviewed UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) Ogt Rattus norvegicus (Rat) 1036 apoptotic process [GO:0006915]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to toxic substance [GO:0097237]; circadian regulation of gene expression [GO:0032922]; forebrain development [GO:0030900]; glucosamine metabolic process [GO:0006041]; histone H3-K4 trimethylation [GO:0080182]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; intracellular distribution of mitochondria [GO:0048312]; negative regulation of cell death [GO:0060548]; negative regulation of cellular response to hypoxia [GO:1900038]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of protein ubiquitination [GO:0031397]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of cell size [GO:0045793]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K27 methylation [GO:0061087]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of proteolysis [GO:0045862]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein heterotrimerization [GO:0070208]; protein homotrimerization [GO:0070207]; protein O-linked glycosylation [GO:0006493]; regulation of gluconeogenesis involved in cellular glucose homeostasis [GO:0090526]; regulation of glycolytic process [GO:0006110] GO:0000123; GO:0000791; GO:0001933; GO:0001934; GO:0005547; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006041; GO:0006110; GO:0006493; GO:0006915; GO:0008134; GO:0010628; GO:0010801; GO:0016262; GO:0019904; GO:0030900; GO:0031397; GO:0032869; GO:0032922; GO:0033137; GO:0042277; GO:0042588; GO:0043005; GO:0043025; GO:0043981; GO:0043982; GO:0043984; GO:0045793; GO:0045862; GO:0045944; GO:0048015; GO:0048029; GO:0048312; GO:0060548; GO:0061087; GO:0070207; GO:0070208; GO:0071222; GO:0071333; GO:0080182; GO:0090315; GO:0090526; GO:0097237; GO:0097363; GO:1900038; GO:1900182; GO:1903428 PATHWAY: Protein modification; protein glycosylation. 0 0 PF13844;PF00515;PF13414;PF13181; P83877 CHOYP_TXN4A.1.2 m.59542 sp TXN4A_MOUSE 85.915 142 20 0 1 142 1 142 2.66E-93 268 TXN4A_MOUSE reviewed Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD) Txnl4a Dim1 Txnl4 Mus musculus (Mouse) 142 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; spliceosomal complex assembly [GO:0000245] GO:0000245; GO:0005634; GO:0005681; GO:0005682; GO:0005737; GO:0007067; GO:0046540; GO:0051301 0 0 0 PF02966; P83877 CHOYP_TXN4A.2.2 m.59596 sp TXN4A_MOUSE 85.915 142 20 0 1 142 1 142 2.66E-93 268 TXN4A_MOUSE reviewed Thioredoxin-like protein 4A (DIM1 protein homolog) (Spliceosomal U5 snRNP-specific 15 kDa protein) (Thioredoxin-like U5 snRNP protein U5-15kD) Txnl4a Dim1 Txnl4 Mus musculus (Mouse) 142 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; spliceosomal complex assembly [GO:0000245] GO:0000245; GO:0005634; GO:0005681; GO:0005682; GO:0005737; GO:0007067; GO:0046540; GO:0051301 0 0 0 PF02966; Q11118 CHOYP_LOC100377422.1.2 m.54122 sp WOS2_SCHPO 37.736 159 80 6 10 150 12 169 2.66E-28 106 WOS2_SCHPO reviewed Protein wos2 (p21) wos2 SPAC9E9.13 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 186 cell cycle [GO:0007049] GO:0005634; GO:0005829; GO:0007049 0 0 0 PF04969; Q14152 CHOYP_contig_015148 m.17556 sp EIF3A_HUMAN 48.387 62 32 0 58 119 611 672 2.66E-07 50.8 EIF3A_HUMAN reviewed Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) EIF3A EIF3S10 KIAA0139 Homo sapiens (Human) 1382 formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; IRES-dependent viral translational initiation [GO:0075522]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral translational termination-reinitiation [GO:0075525] GO:0001731; GO:0001732; GO:0003743; GO:0005198; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005852; GO:0006413; GO:0006446; GO:0016020; GO:0016282; GO:0033290; GO:0044822; GO:0071541; GO:0075522; GO:0075525 0 0 0 PF01399; Q28709 CHOYP_SODM.2.2 m.62946 sp CD63_RABIT 34.091 132 78 3 46 171 110 238 2.66E-22 92.4 CD63_RABIT reviewed CD63 antigen (CD antigen CD63) CD63 Oryctolagus cuniculus (Rabbit) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; endosome to melanosome transport [GO:0035646]; pigment granule maturation [GO:0048757]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005765; GO:0007160; GO:0015031; GO:0016021; GO:0016477; GO:0031226; GO:0031902; GO:0035646; GO:0042470; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2001046 0 0 0 PF00335; Q2PZL6 CHOYP_FAT4.2.10 m.2621 sp FAT4_MOUSE 28.106 2487 1521 92 237 2621 120 2441 2.66E-179 626 FAT4_MOUSE reviewed Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0008543; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072006; GO:0072137; GO:0072307 0 0 0 PF00028;PF00008;PF07645;PF12661;PF02210; Q32P51 CHOYP_ROA3.1.2 m.10506 sp RA1L2_HUMAN 58.427 89 34 1 37 125 9 94 2.66E-26 103 RA1L2_HUMAN reviewed Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2) HNRNPA1L2 HNRNPA1L Homo sapiens (Human) 320 mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0051028 0 0 0 PF11627;PF00076; Q3UZZ6 CHOYP_LOC100341088.1.1 m.20236 sp ST1D1_MOUSE 32.62 187 108 6 21 196 19 198 2.66E-28 111 ST1D1_MOUSE reviewed Sulfotransferase 1 family member D1 (ST1D1) (EC 2.8.2.-) (Amine N-sulfotransferase) (SULT-N) (Dopamine sulfotransferase Sult1d1) (Tyrosine-ester sulfotransferase) Sult1d1 St1d1 Mus musculus (Mouse) 295 catecholamine metabolic process [GO:0006584]; lipid metabolic process [GO:0006629]; sulfate assimilation [GO:0000103]; sulfation [GO:0051923] GO:0000103; GO:0004062; GO:0005737; GO:0006584; GO:0006629; GO:0008146; GO:0051923 0 0 0 PF00685; Q497B8 CHOYP_BRAFLDRAFT_129074.1.1 m.25032 sp KDM8_RAT 28.283 297 172 7 5 267 124 413 2.66E-25 110 KDM8_RAT reviewed Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) Kdm8 Jmjd5 Rattus norvegicus (Rat) 414 "G2/M transition of mitotic cell cycle [GO:0000086]; histone H3-K36 demethylation [GO:0070544]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0003682; GO:0005634; GO:0006351; GO:0045893; GO:0046872; GO:0051864; GO:0070544 0 0 0 0 Q5I7G2 CHOYP_NR2.1.1 m.42974 sp RXR_LYMST 34.336 399 210 5 115 504 74 429 2.66E-71 236 RXR_LYMST reviewed Retinoic acid receptor RXR (Retinoid X receptor) (LymRXR) RXR Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 436 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0005737; GO:0006351; GO:0007275; GO:0008270; GO:0016020; GO:0016918; GO:0030424; GO:0030426; GO:0043565 0 0 0 PF00104;PF00105; Q5R5Y3 CHOYP_ISCW_ISCW003730.1.1 m.14606 sp B3GT2_PONAB 35.273 275 167 7 52 317 128 400 2.66E-51 177 B3GT2_PONAB reviewed "Beta-1,3-galactosyltransferase 2 (Beta-1,3-GalTase 2) (Beta3Gal-T2) (Beta3GalT2) (EC 2.4.1.-) (UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2)" B3GALT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 422 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q60787 CHOYP_LCP2.9.14 m.26687 sp LCP2_MOUSE 30.568 229 133 6 474 686 305 523 2.66E-19 95.5 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q64459 CHOYP_LOC100658511.1.1 m.46906 sp CP3AB_MOUSE 32.5 160 103 4 2 160 7 162 2.66E-20 95.1 CP3AB_MOUSE reviewed Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (Cytochrome P-450IIIAM1) (Cytochrome P-450UT) Cyp3a11 Cyp3a-11 Mus musculus (Mouse) 504 0 GO:0004497; GO:0005506; GO:0005789; GO:0016491; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q6DG38 CHOYP_PHUM_PHUM419710.1.1 m.44424 sp GPAT3_DANRE 56.329 158 68 1 1 157 170 327 2.66E-61 199 GPAT3_DANRE reviewed Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) gpat3 agpat9 si:ch211-85e10.5 zgc:91857 Danio rerio (Zebrafish) (Brachydanio rerio) 449 CDP-diacylglycerol biosynthetic process [GO:0016024]; triglyceride biosynthetic process [GO:0019432] GO:0003841; GO:0004366; GO:0005789; GO:0016021; GO:0016024; GO:0019432 PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.; PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. 0 0 PF01553; Q6XPS3 CHOYP_LOC752773.1.2 m.54742 sp TPTE2_HUMAN 44.762 420 208 8 160 573 118 519 2.66E-124 379 TPTE2_HUMAN reviewed "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)" TPTE2 TPIP Homo sapiens (Human) 522 phosphatidylinositol biosynthetic process [GO:0006661] GO:0000139; GO:0004725; GO:0005789; GO:0006661; GO:0008138; GO:0016021; GO:0016314; GO:0051800 0 0 0 PF00782;PF10409; Q7Z5L3 CHOYP_C1QT6.1.1 m.65308 sp C1QL2_HUMAN 33.333 132 80 3 18 147 160 285 2.66E-13 68.6 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q8BP86 CHOYP_LOC100546924.1.2 m.34506 sp SNPC4_MOUSE 34.052 464 258 10 87 546 79 498 2.66E-65 248 SNPC4_MOUSE reviewed snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Snapc4 Mus musculus (Mouse) 1333 "regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase III promoter [GO:0042796]; snRNA transcription from RNA polymerase II promoter [GO:0042795]" GO:0003677; GO:0006355; GO:0019185; GO:0042795; GO:0042796 0 0 0 0 Q8CIR4 CHOYP_SMP_173720.2.3 m.52988 sp TRPM6_MOUSE 27.181 1284 689 37 85 1217 7 1195 2.66E-118 414 TRPM6_MOUSE reviewed Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) Trpm6 Mus musculus (Mouse) 2028 metal ion transport [GO:0030001]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636] GO:0004674; GO:0005261; GO:0005262; GO:0005524; GO:0009636; GO:0016021; GO:0016324; GO:0030001; GO:0031526; GO:0046872; GO:0051262 0 0 0 PF02816;PF00520;PF16519; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.27.34 m.56721 sp VWDE_HUMAN 24.922 638 390 33 15 607 8 601 2.66E-16 88.6 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NDI1 CHOYP_EHBP1.1.2 m.3418 sp EHBP1_HUMAN 45.075 599 262 10 2 546 3 588 2.66E-152 488 EHBP1_HUMAN reviewed EH domain-binding protein 1 EHBP1 KIAA0903 NACSIN Homo sapiens (Human) 1231 0 GO:0005737; GO:0005886 0 0 0 PF00307;PF12130;PF10358; Q8WQI5 CHOYP_RS8.8.14 m.44842 sp RS8_SPOFR 72.34 188 50 1 4 191 21 206 2.66E-91 282 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q99M80 CHOYP_PTN11.1.4 m.20947 sp PTPRT_MOUSE 33.24 358 192 11 285 597 714 1069 2.66E-43 170 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BWH6 CHOYP_RPAP1.4.4 m.51261 sp RPAP1_HUMAN 34.735 452 260 10 63 497 889 1322 2.66E-69 244 RPAP1_HUMAN reviewed RNA polymerase II-associated protein 1 RPAP1 KIAA1403 Homo sapiens (Human) 1393 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0006366 0 0 0 PF08620;PF08621; Q9ERH6 CHOYP_LOC100708199.6.6 m.57029 sp MOAP1_MOUSE 28.125 128 87 2 110 232 166 293 2.66E-08 58.9 MOAP1_MOUSE reviewed Modulator of apoptosis 1 (MAP-1) Moap1 Mus musculus (Mouse) 352 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of apoptotic process [GO:0043065]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; regulation of apoptotic process [GO:0042981] GO:0001844; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0006915; GO:0008625; GO:0008630; GO:0031625; GO:0042981; GO:0043065; GO:0090200; GO:0097190; GO:0097192 0 0 0 PF14893; Q9N1T2 CHOYP_RPGRB.1.1 m.59104 sp RPGR_CANLF 42.946 482 231 13 9 471 8 464 2.66E-115 378 RPGR_CANLF reviewed X-linked retinitis pigmentosa GTPase regulator RPGR Canis lupus familiaris (Dog) (Canis familiaris) 1003 cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005085; GO:0005794; GO:0005813; GO:0007601; GO:0036064; GO:0036126; GO:0042073; GO:0042384; GO:0050896 0 0 0 PF00415; Q9WWW2 CHOYP_LOC100646609.1.1 m.54207 sp ALKJ_PSEPU 37.391 575 292 19 86 641 2 527 2.66E-100 320 ALKJ_PSEPU reviewed Alcohol dehydrogenase [acceptor] (EC 1.1.99.-) alkJ Pseudomonas putida (Arthrobacter siderocapsulatus) 552 0 GO:0005886; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; D3ZAT9 CHOYP_LOC100377010.6.16 m.36315 sp FAXC_RAT 35.827 254 148 5 31 275 87 334 2.67E-49 171 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; O13356 CHOYP_LOC100212386.2.2 m.34813 sp CHS1_CRYNH 31.541 279 147 10 313 559 585 851 2.67E-22 107 CHS1_CRYNH reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) (Class-IV chitin synthase 1) CHS1 CNAG_03099 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 1236 cell wall organization [GO:0071555] GO:0004100; GO:0005886; GO:0016021; GO:0071555 0 0 0 0 O43734 CHOYP_TRAF3IP3.1.1 m.55725 sp CIKS_HUMAN 33.099 142 84 6 366 505 410 542 2.67E-15 82.4 CIKS_HUMAN reviewed Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 Homo sapiens (Human) 574 B cell apoptotic process [GO:0001783]; humoral immune response [GO:0006959]; immunoglobulin secretion [GO:0048305]; intracellular signal transduction [GO:0035556]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0001783; GO:0002230; GO:0005622; GO:0006959; GO:0035556; GO:0043123; GO:0048305 0 0 0 PF08357; O60285 CHOYP_NUAK1.1.1 m.8910 sp NUAK1_HUMAN 63.197 269 99 0 27 295 45 313 2.67E-123 380 NUAK1_HUMAN reviewed NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1) NUAK1 ARK5 KIAA0537 OMPHK1 Homo sapiens (Human) 661 cell adhesion [GO:0007155]; cellular response to DNA damage stimulus [GO:0006974]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of cell adhesion [GO:0030155]; regulation of cell proliferation [GO:0042127]; regulation of cellular senescence [GO:2000772]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of signal transduction by p53 class mediator [GO:1901796] GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006468; GO:0006974; GO:0007155; GO:0015630; GO:0030155; GO:0035507; GO:0035556; GO:0042127; GO:0046872; GO:1901796; GO:2000772 0 0 0 PF00069; O75382 CHOYP_BRAFLDRAFT_109858.1.6 m.388 sp TRIM3_HUMAN 22.072 222 150 7 258 469 536 744 2.67E-07 57 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75901 CHOYP_LOC100373782.1.1 m.64834 sp RASF9_HUMAN 29.48 346 202 9 10 322 28 364 2.67E-25 111 RASF9_HUMAN reviewed Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor) RASSF9 PAMCI PCIP1 Homo sapiens (Human) 435 endosomal transport [GO:0016197]; protein targeting [GO:0006605]; signal transduction [GO:0007165] GO:0005215; GO:0005768; GO:0005829; GO:0006605; GO:0007165; GO:0012510; GO:0016197; GO:0070062 0 0 0 0 P16157 CHOYP_LOC579825.1.1 m.33754 sp ANK1_HUMAN 33.472 723 432 6 762 1453 82 786 2.67E-103 369 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_LOC755512.5.5 m.54160 sp ANK1_HUMAN 37.079 267 168 0 8 274 241 507 2.67E-46 169 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P27473 CHOYP_SI_CH211-197G15.7.2.3 m.54987 sp IFI44_PANTR 30.82 451 269 11 23 466 24 438 2.67E-55 193 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P51522 CHOYP_ZN227.2.3 m.24342 sp ZNF83_HUMAN 33.681 383 228 8 192 569 122 483 2.67E-48 181 ZNF83_HUMAN reviewed Zinc finger protein 83 (Zinc finger protein 816B) (Zinc finger protein HPF1) ZNF83 ZNF816B Homo sapiens (Human) 516 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q15149 CHOYP_LOC100881043.1.1 m.65033 sp PLEC_HUMAN 20.41 1269 695 46 322 1430 3441 4554 2.67E-13 80.5 PLEC_HUMAN reviewed Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) PLEC PLEC1 Homo sapiens (Human) 4684 hemidesmosome assembly [GO:0031581] GO:0005737; GO:0005829; GO:0005886; GO:0005903; GO:0005913; GO:0005925; GO:0008307; GO:0016528; GO:0030056; GO:0030506; GO:0031012; GO:0031581; GO:0042383; GO:0043034; GO:0044822; GO:0045111; GO:0070062; GO:0098641 0 0 0 PF00307;PF00681;PF03501; Q1L673 CHOYP_ISCW_ISCW009328.1.2 m.17343 sp VDRB_DANRE 31.043 422 229 13 62 444 22 420 2.67E-56 194 VDRB_DANRE reviewed "Vitamin D3 receptor B (VDR-B) (1,25-dihydroxyvitamin D3 receptor B) (Nuclear receptor subfamily 1 group I member 1-B)" vdrb nr1i1b gb:dq017633 Danio rerio (Zebrafish) (Brachydanio rerio) 422 "heart jogging [GO:0003146]; heart looping [GO:0001947]; transcription, DNA-templated [GO:0006351]" GO:0001947; GO:0003146; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0008434; GO:0043565 0 0 0 PF00104;PF00105; Q3T0L7 CHOYP_RL28.1.2 m.5740 sp RL28_BOVIN 55.952 84 37 0 12 95 10 93 2.67E-28 102 RL28_BOVIN reviewed 60S ribosomal protein L28 RPL28 Bos taurus (Bovine) 137 positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022625; GO:0030425; GO:0036464; GO:0044297; GO:0044822; GO:0070062; GO:1903146; GO:1903955 0 0 0 PF01778; Q3U3C9 CHOYP_BRAFLDRAFT_118796.1.1 m.63891 sp GSE1_MOUSE 32.911 79 53 0 595 673 1118 1196 2.67E-07 57.8 GSE1_MOUSE reviewed Genetic suppressor element 1 Gse1 Kiaa0182 Mus musculus (Mouse) 1213 0 0 0 0 0 PF12540; Q460N3 CHOYP_PARP9.1.1 m.61223 sp PAR15_HUMAN 25.725 276 186 7 936 1195 104 376 2.67E-18 95.1 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q502M6 CHOYP_TVAG_123950.2.31 m.21057 sp ANR29_DANRE 37.423 163 102 0 3 165 53 215 2.67E-28 112 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q55EH8 CHOYP_DMOJ_GI22239.1.1 m.6936 sp ABCGN_DICDI 45.968 248 128 2 3 250 4 245 2.67E-73 240 ABCGN_DICDI reviewed ABC transporter G family member 23 (ABC transporter ABCG.23) abcG23 DDB_G0269026 Dictyostelium discoideum (Slime mold) 701 transport [GO:0006810] GO:0005524; GO:0006810; GO:0016021; GO:0016887 0 0 0 PF00005; Q5RCG9 CHOYP_PFD3.1.1 m.56418 sp PFD3_PONAB 66.061 165 56 0 44 208 23 187 2.67E-78 236 PFD3_PONAB reviewed Prefoldin subunit 3 (Von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) VBP1 PFDN3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 197 protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0006457; GO:0016272 0 0 0 PF02996; Q5W9T5 CHOYP_GRPR.1.1 m.25832 sp OPR_OCTVU 21.994 341 237 10 22 351 40 362 2.67E-11 67.8 OPR_OCTVU reviewed Octopressin receptor OPR OTR Octopus vulgaris (Common octopus) 419 G-protein coupled receptor signaling pathway [GO:0007186] GO:0004930; GO:0005000; GO:0005886; GO:0007186; GO:0016021 0 0 0 PF00001; Q8C6L5 CHOYP_NEMVEDRAFT_V1G218264.2.14 m.3604 sp CGAS_MOUSE 26.144 153 99 3 196 334 328 480 2.67E-07 57 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8NHH1 CHOYP_BRAFLDRAFT_86836.1.2 m.27736 sp TTL11_HUMAN 41.653 629 286 9 34 659 196 746 2.67E-161 489 TTL11_HUMAN reviewed Tubulin polyglutamylase TTLL11 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 11) TTLL11 C9orf20 Homo sapiens (Human) 800 microtubule severing [GO:0051013]; protein polyglutamylation [GO:0018095] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0016874; GO:0018095; GO:0051013 0 0 0 PF03133; Q8TER0 CHOYP_LOC574757.7.9 m.49416 sp SNED1_HUMAN 48.473 262 132 2 29 289 22 281 2.67E-69 258 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q96GP6 CHOYP_LOC579946.18.24 m.53554 sp SREC2_HUMAN 40.594 101 58 2 218 318 250 348 2.67E-15 80.5 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q99K01 CHOYP_PDXDC1.1.1 m.11298 sp PDXD1_MOUSE 37.337 766 389 12 123 881 11 692 2.67E-169 515 PDXD1_MOUSE reviewed Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) Pdxdc1 Mus musculus (Mouse) 787 carboxylic acid metabolic process [GO:0019752] GO:0005794; GO:0016831; GO:0019752; GO:0030170; GO:0043231 0 0 0 PF00282; Q9EQ06 CHOYP_LOC100377066.1.2 m.18381 sp DHB11_MOUSE 42.857 266 152 0 23 288 17 282 2.67E-79 246 DHB11_MOUSE reviewed Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8) Hsd17b11 Dhrs8 Pan1b Mus musculus (Mouse) 298 androgen catabolic process [GO:0006710]; steroid biosynthetic process [GO:0006694] GO:0004303; GO:0005576; GO:0005737; GO:0005811; GO:0006694; GO:0006710; GO:0016229; GO:0043231 0 0 0 PF00106; Q9LQV2 CHOYP_BRAFLDRAFT_99723.5.9 m.47251 sp RDR1_ARATH 39.148 751 408 16 372 1095 369 1097 2.67E-138 457 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; Q9UBU6 CHOYP_LOC100875027.1.1 m.1255 sp FA8A1_HUMAN 29.341 334 161 10 5 283 94 407 2.67E-35 134 FA8A1_HUMAN reviewed Protein FAM8A1 (Autosomal highly conserved protein) FAM8A1 AHCP Homo sapiens (Human) 413 0 GO:0016021 0 0 0 PF06271; Q9XWD6 CHOYP_LOC100701872.6.7 m.55491 sp CED1_CAEEL 38.034 234 126 11 129 360 593 809 2.67E-25 113 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; A4IGL7 CHOYP_BRAFLDRAFT_79792.2.2 m.31520 sp PXDN_XENTR 27.354 223 146 6 8 228 292 500 2.68E-15 79.7 PXDN_XENTR reviewed Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1457 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF03098;PF07679;PF13855;PF00093; A5PKK7 CHOYP_GORAB.2.2 m.66930 sp GORAB_BOVIN 31.14 228 94 7 3 184 4 214 2.68E-19 87 GORAB_BOVIN reviewed RAB6-interacting golgin (N-terminal kinase-like-binding protein 1) (NTKL-BP1) (NTKL-binding protein 1) (SCY1-like 1-binding protein 1) (SCYL1-BP1) (SCYL1-binding protein 1) GORAB SCYL1BP1 Bos taurus (Bovine) 370 0 GO:0005794 0 0 0 PF04949; A6H603 CHOYP_LOC100366460.1.2 m.31783 sp NWD1_MOUSE 29.122 934 597 23 101 1013 1 890 2.68E-100 350 NWD1_MOUSE reviewed NACHT domain- and WD repeat-containing protein 1 Nwd1 Mus musculus (Mouse) 1563 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; A9JS71 CHOYP_LOC100695307.1.1 m.51209 sp ECHD3_XENLA 62.698 252 92 1 40 289 42 293 2.68E-117 342 ECHD3_XENLA reviewed "Enoyl-CoA hydratase domain-containing protein 3, mitochondrial" echdc3 Xenopus laevis (African clawed frog) 294 metabolic process [GO:0008152] GO:0003824; GO:0005739; GO:0008152 0 0 0 PF00378; B3EWZ5 CHOYP_LOC100183059.1.4 m.2977 sp MLRP1_ACRMI 31.633 196 98 7 193 384 1123 1286 2.68E-17 89.7 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E1BD59 CHOYP_NEMVEDRAFT_V1G217091.2.4 m.33885 sp TRI56_BOVIN 24.627 268 178 8 6 262 9 263 2.68E-15 82.4 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; E1BLZ4 CHOYP_BRAFLDRAFT_65850.1.1 m.8417 sp ZFY26_BOVIN 35.517 977 524 21 14 965 1605 2500 2.68E-167 545 ZFY26_BOVIN reviewed Zinc finger FYVE domain-containing protein 26 ZFYVE26 Bos taurus (Bovine) 2515 cytokinesis [GO:0000910]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0000910; GO:0005765; GO:0005813; GO:0030496; GO:0032266; GO:0046872 0 0 0 PF01363; E7FAM5 CHOYP_LOC100373444.43.79 m.37746 sp LIN41_DANRE 20.124 646 390 22 12 552 151 775 2.68E-11 70.1 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; E9Q9A9 CHOYP_LOC100770794.1.1 m.66066 sp OAS2_MOUSE 29.217 332 200 8 7 305 379 708 2.68E-37 144 OAS2_MOUSE reviewed "2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (2',5'-oligoadenylate synthetase-like 11)" Oas2 oasl11 Mus musculus (Mouse) 742 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; protein glycosylation [GO:0006486]; protein myristoylation [GO:0018377]; purine nucleotide biosynthetic process [GO:0006164]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401] GO:0001730; GO:0003725; GO:0005524; GO:0005634; GO:0005739; GO:0005783; GO:0006164; GO:0006401; GO:0006486; GO:0008270; GO:0009615; GO:0016020; GO:0018377; GO:0045087; GO:0048471; GO:0051607 0 0 0 PF01909;PF10421; O07552 CHOYP_SMP_001000.1.1 m.39561 sp NHAX_BACSU 26.087 161 104 5 12 158 7 166 2.68E-10 59.3 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O43312 CHOYP_MTSSL.1.1 m.48209 sp MTSS1_HUMAN 56.845 336 120 5 1 317 1 330 2.68E-117 376 MTSS1_HUMAN reviewed Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) 755 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; movement of cell or subcellular component [GO:0006928]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of defense response to virus by host [GO:0002230]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; xenophagy [GO:0098792] GO:0001726; GO:0002230; GO:0003785; GO:0005102; GO:0005737; GO:0006928; GO:0007009; GO:0007155; GO:0007169; GO:0015629; GO:0030035; GO:0030036; GO:0030139; GO:0042802; GO:0050680; GO:0061333; GO:0071498; GO:0072102; GO:0072160; GO:0098792; GO:2001013 0 0 0 PF08397;PF02205; O75311 CHOYP_GLRA3.2.2 m.55944 sp GLRA3_HUMAN 38.725 408 209 8 45 430 63 451 2.68E-99 307 GLRA3_HUMAN reviewed Glycine receptor subunit alpha-3 GLRA3 Homo sapiens (Human) 464 "chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; protein homooligomerization [GO:0051260]; response to amino acid [GO:0043200]; synaptic transmission, glycinergic [GO:0060012]" GO:0005886; GO:0005887; GO:0007218; GO:0016594; GO:0016934; GO:0016935; GO:0022852; GO:0030054; GO:0030425; GO:0034220; GO:0043200; GO:0043204; GO:0045211; GO:0046872; GO:0051260; GO:0060012; GO:1902476 0 0 0 PF02931;PF02932; P18948 CHOYP_BRAFLDRAFT_70363.1.1 m.19835 sp VIT6_CAEEL 21.743 1067 704 26 28 1066 33 996 2.68E-53 211 VIT6_CAEEL reviewed Vitellogenin-6 vit-6 K07H8.6 Caenorhabditis elegans 1651 0 GO:0005319; GO:0005576; GO:0045735 0 0 0 PF09172;PF01347;PF00094; P24775 CHOYP_LOC100368303.1.1 m.9992 sp RET4B_ONCMY 25.424 177 124 7 28 200 1 173 2.68E-06 49.3 RET4B_ONCMY reviewed Retinol-binding protein 4-B (Plasma retinol-binding protein 2) (PRBP-2) (Plasma retinol-binding protein II) (PRBP-II) rbp4b Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 176 0 GO:0005215; GO:0005615; GO:0019841; GO:0060417 0 0 0 PF00061; P55142 CHOYP_PMAR_PMAR003946.2.2 m.31102 sp GRXC6_ORYSJ 44.681 94 45 2 11 104 10 96 2.68E-21 84 GRXC6_ORYSJ reviewed Glutaredoxin-C6 (Glutaredoxin-C2 homolog 1) GRXC6 RASC8 Os04g0508300 LOC_Os04g42930 OsJ_15409 OSJNBa0043L24.17 Oryza sativa subsp. japonica (Rice) 112 cell redox homeostasis [GO:0045454] GO:0005737; GO:0009055; GO:0015035; GO:0045454 0 0 0 PF00462; P80646 CHOYP_CTRA.2.2 m.26708 sp CTRB_GADMO 39.827 231 132 6 283 510 16 242 2.68E-49 172 CTRB_GADMO reviewed Chymotrypsin B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B] 0 Gadus morhua (Atlantic cod) 245 digestion [GO:0007586] GO:0004252; GO:0005615; GO:0007586 0 0 cd00190; PF00089; Q24307 CHOYP_IAP2.1.5 m.4148 sp DIAP2_DROME 48.333 60 31 0 289 348 437 496 2.68E-12 71.2 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q29L80 CHOYP_LOC100890512.1.1 m.36423 sp PITH1_DROPS 53.731 201 88 3 4 201 3 201 2.68E-67 208 PITH1_DROPS reviewed PITH domain-containing protein GA19395 GA19395 Drosophila pseudoobscura pseudoobscura (Fruit fly) 211 0 0 0 0 0 PF06201; Q497Q6 CHOYP_LOC582953.1.1 m.12150 sp F228B_MOUSE 31.461 178 116 2 29 202 50 225 2.68E-24 99.4 F228B_MOUSE reviewed Protein FAM228B Fam228b Mus musculus (Mouse) 232 0 0 0 0 0 0 Q52KI8 CHOYP_LOC588572.1.2 m.17892 sp SRRM1_MOUSE 63.804 163 56 2 2 164 1 160 2.68E-59 224 SRRM1_MOUSE reviewed Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101) Srrm1 Pop101 Mus musculus (Mouse) 946 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0003677; GO:0005681; GO:0016363; GO:0016607 0 0 0 PF01480; Q58A42 CHOYP_LOC100372842.1.1 m.26583 sp DD3_DICDI 34.557 654 301 22 19 662 21 557 2.68E-95 310 DD3_DICDI reviewed Protein DD3-3 DD3-3 DDB_G0283095 Dictyostelium discoideum (Slime mold) 616 0 GO:0016021 0 0 0 0 Q5PQL3 CHOYP_SPPL2.1.1 m.38023 sp SPP2B_RAT 38.043 92 54 2 41 131 35 124 2.68E-11 62.8 SPP2B_RAT reviewed Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) Sppl2b Rattus norvegicus (Rat) 577 membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; signal peptide processing [GO:0006465] GO:0000139; GO:0005654; GO:0005765; GO:0005813; GO:0005886; GO:0006465; GO:0006509; GO:0010008; GO:0015629; GO:0016020; GO:0030660; GO:0031293; GO:0033619; GO:0042500; GO:0042803; GO:0050776; GO:0071458; GO:0071556 0 0 0 PF02225;PF04258; Q5R5M4 CHOYP_DVIR_GJ11733.1.1 m.17755 sp MOT9_PONAB 24.419 172 124 3 12 182 327 493 2.68E-12 68.2 MOT9_PONAB reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 509 0 GO:0005886; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q5RKZ7 CHOYP_BRAFLDRAFT_118735.1.1 m.6990 sp MOCS1_MOUSE 65.455 330 111 1 52 381 58 384 2.68E-164 477 MOCS1_MOUSE reviewed Molybdenum cofactor biosynthesis protein 1 [Includes: Cyclic pyranopterin monophosphate synthase (EC 4.1.99.18) (Molybdenum cofactor biosynthesis protein A); Cyclic pyranopterin monophosphate synthase accessory protein (Molybdenum cofactor biosynthesis protein C)] Mocs1 Mus musculus (Mouse) 636 molybdopterin cofactor biosynthetic process [GO:0032324]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0005525; GO:0006777; GO:0019008; GO:0032324; GO:0046872; GO:0051539; GO:0061597 PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. 0 cd01420; PF01967;PF06463;PF04055; Q5ZKX6 CHOYP_UBE2F.1.1 m.7146 sp UBE2F_CHICK 64.13 184 64 1 1 182 1 184 2.68E-87 257 UBE2F_CHICK reviewed NEDD8-conjugating enzyme UBE2F (EC 6.3.2.-) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (Ubiquitin-conjugating enzyme E2 F) UBE2F RCJMB04_8m10 Gallus gallus (Chicken) 185 postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; protein neddylation [GO:0045116] GO:0005524; GO:0005634; GO:0005737; GO:0006301; GO:0016874; GO:0019788; GO:0031625; GO:0045116; GO:0061630; GO:0070534 PATHWAY: Protein modification; protein neddylation. 0 0 PF00179; Q6MG64 CHOYP_LOC100700958.1.1 m.49341 sp VWA7_RAT 25.359 627 377 21 44 642 40 603 2.68E-37 152 VWA7_RAT reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) 892 0 GO:0005576 0 0 0 0 Q6NRD5 CHOYP_DWIL_GK23167.1.1 m.4845 sp EXD1_XENLA 26.484 219 144 7 7 219 85 292 2.68E-10 65.9 EXD1_XENLA reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) exd1 exdl1 Xenopus laevis (African clawed frog) 444 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q7PCJ9 CHOYP_BRAFLDRAFT_285620.1.6 m.2457 sp SAT2_PIG 33.108 148 86 4 1 138 24 168 2.68E-20 84.7 SAT2_PIG reviewed Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) SAT2 SSAT2 Sus scrofa (Pig) 170 putrescine catabolic process [GO:0009447] GO:0004145; GO:0005737; GO:0009447 PATHWAY: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. 0 0 PF00583; Q7TPQ9 CHOYP_ARRD3.2.2 m.64983 sp ARRD3_MOUSE 28.667 300 196 7 15 305 23 313 2.68E-26 112 ARRD3_MOUSE reviewed Arrestin domain-containing protein 3 Arrdc3 Kiaa1376 Mus musculus (Mouse) 414 fat pad development [GO:0060613]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of multicellular organismal metabolic process [GO:0044252]; positive regulation of adrenergic receptor signaling pathway [GO:0071879]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; skin development [GO:0043588]; temperature homeostasis [GO:0001659] GO:0001659; GO:0005764; GO:0005768; GO:0005769; GO:0005886; GO:0031651; GO:0031699; GO:0043588; GO:0044252; GO:0051443; GO:0060613; GO:0071879; GO:0090327 0 0 0 PF02752;PF00339; Q7Z5L3 CHOYP_LOC100693484.1.1 m.5989 sp C1QL2_HUMAN 29.358 109 69 3 67 173 160 262 2.68E-07 52.4 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q8IYB1 CHOYP_NEMVEDRAFT_V1G196611.8.13 m.32810 sp M21D2_HUMAN 25.301 166 104 5 12 170 233 385 2.68E-06 53.5 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8N2E2 CHOYP_BRAFLDRAFT_67520.2.2 m.34594 sp VWDE_HUMAN 27.596 366 219 8 5507 5830 730 1091 2.68E-33 147 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8VC31 CHOYP_LOC100708024.1.2 m.7177 sp CCDC9_MOUSE 44.737 114 57 2 289 400 186 295 2.68E-19 95.9 CCDC9_MOUSE reviewed Coiled-coil domain-containing protein 9 Ccdc9 Mus musculus (Mouse) 543 0 GO:0044822 0 0 0 PF15266; Q92968 CHOYP_LOC594428.1.1 m.58283 sp PEX13_HUMAN 49.527 317 150 6 61 374 52 361 2.68E-93 291 PEX13_HUMAN reviewed Peroxisomal membrane protein PEX13 (Peroxin-13) PEX13 Homo sapiens (Human) 403 "cerebral cortex cell migration [GO:0021795]; fatty acid alpha-oxidation [GO:0001561]; locomotory behavior [GO:0007626]; microtubule-based peroxisome localization [GO:0060152]; mitophagy in response to mitochondrial depolarization [GO:0098779]; neuron migration [GO:0001764]; positive regulation of defense response to virus by host [GO:0002230]; protein import into peroxisome matrix, docking [GO:0016560]; suckling behavior [GO:0001967]; xenophagy [GO:0098792]" GO:0001561; GO:0001764; GO:0001967; GO:0002230; GO:0005777; GO:0005778; GO:0005779; GO:0007626; GO:0016020; GO:0016560; GO:0021795; GO:0043231; GO:0060152; GO:0098779; GO:0098792 0 0 0 PF04088;PF14604; Q99M80 CHOYP_PTPRT.6.45 m.24275 sp PTPRT_MOUSE 31.608 715 432 17 454 1125 753 1453 2.68E-81 295 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BXW7 CHOYP_LOC100183583.2.2 m.42823 sp CECR5_HUMAN 42.453 106 58 1 2 107 116 218 2.68E-22 95.1 CECR5_HUMAN reviewed Cat eye syndrome critical region protein 5 CECR5 Homo sapiens (Human) 423 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q9CR48 CHOYP_DRAM2.2.2 m.56235 sp DRAM2_MOUSE 30.579 242 149 6 37 268 4 236 2.68E-17 83.2 DRAM2_MOUSE reviewed DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) Dram2 Tmem77 Mus musculus (Mouse) 267 apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601] GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006914; GO:0006915; GO:0007601; GO:0010506; GO:0016021; GO:0016324; GO:0043231; GO:0045494 0 0 0 PF10277; Q9H8L6 CHOYP_contig_000538 m.544 sp MMRN2_HUMAN 40.506 79 44 2 85 163 819 894 2.68E-06 50.1 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; A0A0R4IBK5 CHOYP_RNF213.1.4 m.3459 sp R213A_DANRE 28.746 654 424 15 21 667 4580 5198 2.69E-72 259 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A1L4H1 CHOYP_LOC762897.2.3 m.31729 sp SRCRL_HUMAN 42.273 220 115 6 398 611 190 403 2.69E-39 163 SRCRL_HUMAN reviewed Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D) SSC5D Homo sapiens (Human) 1573 defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; negative regulation of interleukin-8 secretion [GO:2000483] GO:0001968; GO:0005044; GO:0005615; GO:0005622; GO:0005737; GO:0007275; GO:0016020; GO:0031012; GO:0042494; GO:0043236; GO:0045087; GO:0050829; GO:0050830; GO:0050840; GO:2000483 0 0 0 PF00530; A7MB10 CHOYP_LOC100722009.1.1 m.1890 sp RRP5_BOVIN 37.179 78 48 1 1 78 728 804 2.69E-10 60.8 RRP5_BOVIN reviewed Protein RRP5 homolog (Programmed cell death protein 11) PDCD11 Bos taurus (Bovine) 1874 mRNA processing [GO:0006397]; rRNA processing [GO:0006364] GO:0003723; GO:0005730; GO:0006364; GO:0006397; GO:0032040 0 0 0 PF00575;PF05843; D2GXS7 CHOYP_BRAFLDRAFT_79421.1.3 m.20235 sp TRIM2_AILME 23.448 145 106 2 114 255 602 744 2.69E-06 52.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43301 CHOYP_BRAFLDRAFT_208436.8.32 m.36574 sp HS12A_HUMAN 34.416 616 330 16 9 564 56 657 2.69E-107 340 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O70277 CHOYP_TRIM3.34.58 m.36768 sp TRIM3_RAT 24.074 270 172 7 301 559 495 742 2.69E-09 63.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P00529 CHOYP_CPIPJ_CPIJ011455.1.1 m.50498 sp ROS_AVISU 59.756 82 33 0 1 82 291 372 2.69E-29 113 ROS_AVISU reviewed Tyrosine-protein kinase transforming protein ros (EC 2.7.10.1) V-ROS UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2)) 402 transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0016020 0 0 0 PF07714; P13608 CHOYP_LECG.4.4 m.45164 sp PGCA_BOVIN 35.766 137 66 4 47 183 2161 2275 2.69E-18 87.4 PGCA_BOVIN reviewed Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Bos taurus (Bovine) 2364 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005576; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; P15308 CHOYP_RS10.1.5 m.853 sp B4_XENLA 41.791 67 32 1 1 67 47 106 2.69E-08 55.1 B4_XENLA reviewed Protein B4 (Histone H1-like protein) (Linker histone B4) b4 Xenopus laevis (African clawed frog) 273 multicellular organism development [GO:0007275]; nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0007275 0 0 0 PF00538; P23286 CHOYP_CALM.35.50 m.49987 sp CALM_CANAX 38.211 123 65 4 12 129 19 135 2.69E-18 79 CALM_CANAX reviewed Calmodulin (CaM) CMD1 Candida albicans (Yeast) 149 0 GO:0005509 0 0 0 PF13499; P24014 CHOYP_SLIT2.3.3 m.58710 sp SLIT_DROME 32.487 197 96 3 24 195 543 727 2.69E-24 106 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P35033 CHOYP_BRAFLDRAFT_277744.2.2 m.28858 sp TRY3_SALSA 46.809 235 109 6 67 299 16 236 2.69E-64 205 TRY3_SALSA reviewed Trypsin-3 (EC 3.4.21.4) (Trypsin III) (Fragment) 0 Salmo salar (Atlantic salmon) 238 digestion [GO:0007586] GO:0004252; GO:0005615; GO:0007586; GO:0046872 0 0 cd00190; PF00089; P43301 CHOYP_EGR1.1.1 m.62655 sp EGR3_RAT 75.373 134 33 0 413 546 251 384 2.69E-67 226 EGR3_RAT reviewed Early growth response protein 3 (EGR-3) Egr3 Egr-3 Rattus norvegicus (Rat) 387 "cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endothelial cell chemotaxis [GO:0035767]; negative regulation of apoptotic process [GO:0043066]; neuromuscular synaptic transmission [GO:0007274]; peripheral nervous system development [GO:0007422]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of T cell differentiation in thymus [GO:0033089]; regulation of gamma-delta T cell differentiation [GO:0045586]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001938; GO:0002042; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007274; GO:0007422; GO:0033089; GO:0035767; GO:0035924; GO:0043066; GO:0044344; GO:0045586; GO:0046872 0 0 0 PF11928; P54680 CHOYP_LOC100369889.1.1 m.26357 sp FIMB_DICDI 38.158 76 44 1 148 223 9 81 2.69E-07 54.3 FIMB_DICDI reviewed Fimbrin fimA DDB_G0277855 Dictyostelium discoideum (Slime mold) 610 actin filament bundle assembly [GO:0051017]; sexual reproduction [GO:0019953] GO:0001891; GO:0005509; GO:0019953; GO:0030027; GO:0031252; GO:0045335; GO:0051015; GO:0051017 0 0 0 PF00307;PF13499; P56656 CHOYP_BRAFLDRAFT_57483.2.2 m.36626 sp CP239_MOUSE 38.494 478 278 6 16 484 20 490 2.69E-110 338 CP239_MOUSE reviewed Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39) Cyp2c39 Mus musculus (Mouse) 490 epoxygenase P450 pathway [GO:0019373] GO:0004497; GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019373; GO:0020037; GO:0031090; GO:0034875; GO:0070330 0 0 0 PF00067; P62752 CHOYP_KI15A.1.1 m.13673 sp RL23A_RAT 71.579 95 27 0 49 143 31 125 2.69E-38 130 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P86947 CHOYP_VRP.1.4 m.12336 sp VRP_PINMA 42.276 123 62 4 1 120 99 215 2.69E-06 47.8 VRP_PINMA reviewed Valine-rich protein (Alveolin-like protein) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 238 0 GO:0005576 0 0 0 0 P97411 CHOYP_LOC100373653.1.3 m.37870 sp ICA69_MOUSE 47.177 496 189 7 6 495 41 469 2.69E-140 415 ICA69_MOUSE reviewed Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) Ica1 Icap69 Mus musculus (Mouse) 478 neurotransmitter transport [GO:0006836]; regulation of insulin secretion [GO:0050796]; regulation of neurotransmitter secretion [GO:0046928]; regulation of protein homodimerization activity [GO:0043496] GO:0000139; GO:0005737; GO:0005794; GO:0005795; GO:0005829; GO:0006836; GO:0030054; GO:0030425; GO:0030667; GO:0030672; GO:0043496; GO:0046928; GO:0048471; GO:0050796 0 0 0 PF06456;PF04629; Q03601 CHOYP_GSPATT00039318001.1.1 m.3114 sp NHL1_CAEEL 31.008 129 77 4 727 848 772 895 2.69E-08 63.2 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q09575 CHOYP_LOC100372999.3.3 m.53718 sp YRD6_CAEEL 32.231 363 213 7 8 343 668 1024 2.69E-53 197 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q0V8E4 CHOYP_ASND1.1.1 m.29488 sp ASND1_BOVIN 44.411 671 285 20 1 626 1 628 2.69E-161 479 ASND1_BOVIN reviewed Asparagine synthetase domain-containing protein 1 ASNSD1 Bos taurus (Bovine) 640 asparagine biosynthetic process [GO:0006529]; glutamine metabolic process [GO:0006541] GO:0004066; GO:0005829; GO:0006529; GO:0006541; GO:0042803 0 0 cd01991; PF00733;PF13537; Q29116 CHOYP_LOC100367879.3.3 m.58996 sp TENA_PIG 41.597 238 132 4 96 330 1500 1733 2.69E-49 180 TENA_PIG reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) 1746 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041; Q32NU8 CHOYP_LOC585718.1.2 m.37839 sp TTC25_XENLA 46.753 77 41 0 12 88 7 83 2.69E-15 73.9 TTC25_XENLA reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Xenopus laevis (African clawed frog) 531 0 0 0 0 0 PF13181; Q5BIM1 CHOYP_BRAFLDRAFT_88224.7.11 m.43249 sp TRI45_BOVIN 22.099 543 331 21 14 498 27 535 2.69E-14 79.7 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5BIM1 CHOYP_TRI36.3.3 m.48252 sp TRI45_BOVIN 28.058 278 169 9 1 262 122 384 2.69E-14 77.8 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5HY98 CHOYP_LOC100888889.1.1 m.14397 sp ZN766_HUMAN 38.037 163 96 4 392 552 243 402 2.69E-22 104 ZN766_HUMAN reviewed Zinc finger protein 766 ZNF766 Homo sapiens (Human) 468 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q62210 CHOYP_BIRC2.3.13 m.20767 sp BIRC2_MOUSE 28.371 356 205 11 208 521 265 612 2.69E-34 140 BIRC2_MOUSE reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (Inhibitor of apoptosis protein 2) (mIAP2) Birc2 Mus musculus (Mouse) 612 "inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0009898; GO:0016740; GO:0016874; GO:0034121; GO:0035631; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0060546; GO:0070266; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000377 0 0 0 PF00653;PF00619; Q6DIB5 CHOYP_MEG10.47.91 m.45614 sp MEG10_MOUSE 39.583 192 102 10 1 192 177 354 2.69E-26 109 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6P1C6 CHOYP_BRAFLDRAFT_88471.1.1 m.24412 sp LRIG3_MOUSE 31 200 126 5 1 196 346 537 2.69E-19 89.4 LRIG3_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) Lrig3 Kiaa3016 Mus musculus (Mouse) 1117 otolith morphogenesis [GO:0032474] GO:0005615; GO:0005886; GO:0016021; GO:0030659; GO:0032474 0 0 0 PF07679;PF13855; Q6PFY8 CHOYP_TRI45.9.23 m.32805 sp TRI45_MOUSE 30.396 227 138 6 49 263 103 321 2.69E-17 88.2 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7K8 CHOYP_Y015.1.1 m.30135 sp Y015_OSHVF 99.533 214 1 0 1 214 1 214 2.69E-161 446 Y015_OSHVF reviewed Uncharacterized protein ORF15 ORF15 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 214 0 0 0 0 0 0 Q868Z9 CHOYP_PPN.3.4 m.50209 sp PPN_DROME 34.426 671 315 17 750 1312 1490 2143 2.69E-99 362 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q8NBI5 CHOYP_LOC100692345.1.1 m.42154 sp S43A3_HUMAN 26.415 424 237 13 10 399 9 391 2.69E-37 144 S43A3_HUMAN reviewed Solute carrier family 43 member 3 (Protein FOAP-13) SLC43A3 PSEC0252 Homo sapiens (Human) 491 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 0 PF07690; Q8NHV1 CHOYP_LOC101165124.2.2 m.59109 sp GIMA7_HUMAN 33.755 237 137 4 360 591 1 222 2.69E-39 150 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8TBH0 CHOYP_LOC591882.1.1 m.41063 sp ARRD2_HUMAN 28.125 224 139 8 5 216 8 221 2.69E-14 74.3 ARRD2_HUMAN reviewed Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) 407 signal transduction [GO:0007165] GO:0005886; GO:0007165; GO:0031410 0 0 0 PF02752;PF00339; Q92630 CHOYP_LOC579475.2.2 m.30967 sp DYRK2_HUMAN 57.534 73 31 0 142 214 153 225 2.69E-22 97.4 DYRK2_HUMAN reviewed Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) DYRK2 Homo sapiens (Human) 601 cellular response to DNA damage stimulus [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of NFAT protein import into nucleus [GO:0051534]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; smoothened signaling pathway [GO:0007224] GO:0000151; GO:0000287; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0006974; GO:0007224; GO:0030145; GO:0030529; GO:0042771; GO:0043130; GO:0045725; GO:0051534; GO:1901796 0 0 0 PF00069; Q9CRC3 CHOYP_AAEL_AAEL009675.1.1 m.61831 sp CO040_MOUSE 48.819 127 56 3 47 167 1 124 2.69E-29 107 CO040_MOUSE reviewed UPF0235 protein C15orf40 homolog 0 Mus musculus (Mouse) 126 0 0 0 0 0 PF02594; Q9CY57 CHOYP_CHTOP.1.1 m.35404 sp CHTOP_MOUSE 63.889 36 9 1 223 258 212 243 2.69E-07 53.5 CHTOP_MOUSE reviewed Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) Chtop Fop MNCb-1706 Mus musculus (Mouse) 249 "mRNA export from nucleus [GO:0006406]; positive regulation of ATPase activity [GO:0032781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of helicase activity [GO:0051096]; positive regulation of histone methylation [GO:0031062]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000346; GO:0005730; GO:0006351; GO:0006355; GO:0006406; GO:0008284; GO:0008327; GO:0016607; GO:0031062; GO:0032781; GO:0044822; GO:0051096 0 0 0 PF13865; Q9H1I8 CHOYP_ASCC2.1.1 m.34978 sp ASCC2_HUMAN 41.828 777 394 23 1 746 1 750 2.69E-176 526 ASCC2_HUMAN reviewed Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100) ASCC2 ASC1P100 Homo sapiens (Human) 757 "DNA dealkylation involved in DNA repair [GO:0006307]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0005667; GO:0006307; GO:0006351; GO:0006355 0 0 0 PF02845; Q9HCK4 CHOYP_ROBO2.1.1 m.64775 sp ROBO2_HUMAN 37.732 917 513 20 1 890 3 888 2.69E-174 564 ROBO2_HUMAN reviewed Roundabout homolog 2 ROBO2 KIAA1568 Homo sapiens (Human) 1378 apoptotic process involved in luteolysis [GO:0061364]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; cellular response to hormone stimulus [GO:0032870]; central nervous system development [GO:0007417]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; negative regulation of synapse assembly [GO:0051964]; olfactory bulb interneuron development [GO:0021891]; positive regulation of axonogenesis [GO:0050772]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657] GO:0001656; GO:0001657; GO:0007156; GO:0007411; GO:0007417; GO:0007420; GO:0008046; GO:0009986; GO:0016021; GO:0016199; GO:0021891; GO:0030673; GO:0031290; GO:0032870; GO:0035385; GO:0042802; GO:0050772; GO:0050925; GO:0051964; GO:0061364; GO:0070062 0 0 0 PF00041;PF07679; Q9JLC8 CHOYP_LOC558150.3.4 m.47821 sp SACS_MOUSE 24.123 456 291 13 1 421 3586 4021 2.69E-17 88.6 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9R0P6 CHOYP_LOC100370285.1.1 m.9643 sp SC11A_MOUSE 86.592 179 24 0 29 207 1 179 2.69E-106 306 SC11A_MOUSE reviewed Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) (Sid 2895) Sec11a Sec11l1 Sid2895 Spc18 Mus musculus (Mouse) 179 signal peptide processing [GO:0006465] GO:0005789; GO:0006465; GO:0008236; GO:0016021; GO:0031090; GO:0070062 0 0 0 PF00717; Q9UBC2 CHOYP_EP15R.1.1 m.14260 sp EP15R_HUMAN 38.92 889 394 26 748 1528 14 861 2.69E-163 518 EP15R_HUMAN reviewed Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) EPS15L1 EPS15R Homo sapiens (Human) 864 endocytosis [GO:0006897]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059] GO:0005509; GO:0005634; GO:0005886; GO:0005913; GO:0006897; GO:0016020; GO:0030132; GO:0042059; GO:0098641 0 0 0 PF12763; Q9Z2A5 CHOYP_ATE1.3.3 m.63570 sp ATE1_MOUSE 45.139 144 74 2 69 208 194 336 2.69E-34 130 ATE1_MOUSE reviewed Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) Ate1 Mus musculus (Mouse) 516 protein arginylation [GO:0016598] GO:0004057; GO:0005634; GO:0005737; GO:0016598 0 0 0 PF04377;PF04376; A1L1V4 CHOYP_LOC100876792.1.1 m.45920 sp LOL2B_DANRE 42.706 377 198 7 594 958 371 741 2.70E-88 301 LOL2B_DANRE reviewed Lysyl oxidase homolog 2B (EC 1.4.3.13) (Lysyl oxidase-like protein 2B) loxl2b si:dkeyp-32b1.1 zgc:158414 Danio rerio (Zebrafish) (Brachydanio rerio) 762 "collagen fibril organization [GO:0030199]; covalent chromatin modification [GO:0016569]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of chondrocyte differentiation [GO:0032332]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; transcription, DNA-templated [GO:0006351]" GO:0001666; GO:0001837; GO:0001935; GO:0002040; GO:0004720; GO:0005044; GO:0005507; GO:0005604; GO:0005634; GO:0005694; GO:0006351; GO:0016020; GO:0016569; GO:0030199; GO:0032332; GO:0043542; GO:0045892 0 0 0 PF01186;PF00530; A1L4L8 CHOYP_CBR-LET-2.1.2 m.37501 sp PL8L1_HUMAN 36.283 113 71 1 4 116 46 157 2.70E-20 84 PL8L1_HUMAN reviewed PLAC8-like protein 1 PLAC8L1 Homo sapiens (Human) 177 0 0 0 0 0 PF04749; A1L4L8 CHOYP_LOC100373752.1.4 m.23401 sp PL8L1_HUMAN 36.283 113 71 1 4 116 46 157 2.70E-20 84 PL8L1_HUMAN reviewed PLAC8-like protein 1 PLAC8L1 Homo sapiens (Human) 177 0 0 0 0 0 PF04749; A2AJ88 CHOYP_PNPLA7.1.1 m.29838 sp PLPL7_MOUSE 32.558 258 131 7 1 235 282 519 2.70E-24 104 PLPL7_MOUSE reviewed Patatin-like phospholipase domain-containing protein 7 (EC 3.1.1.-) (Neuropathy target esterase-related esterase) (NRE) (NTE-related esterase) Pnpla7 Mus musculus (Mouse) 1352 developmental process [GO:0032502]; glycerophospholipid catabolic process [GO:0046475] GO:0004622; GO:0005765; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0031966; GO:0032502; GO:0046475 0 0 0 PF00027;PF01734; H2A0L8 CHOYP_FND2.2.4 m.19974 sp FND2_PINMG 51.852 162 78 0 2 163 358 519 2.70E-52 179 FND2_PINMG reviewed Fibronectin type III domain-containing protein 2 0 Pinctada margaritifera (Black-lipped pearl oyster) 624 0 GO:0005576 0 0 0 PF00041; O02389 CHOYP_TPM.6.19 m.12415 sp TPM_CHLNI 68.421 152 48 0 48 199 82 233 2.70E-58 188 TPM_CHLNI reviewed Tropomyosin 0 Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) 284 0 0 0 0 0 PF00261; O16011 CHOYP_DSEC_GM21767.1.1 m.63020 sp MBL_DROME 46.725 229 71 10 1 228 1 179 2.70E-49 170 MBL_DROME reviewed Protein muscleblind (Protein mindmelt) mbl mm CG33197 Drosophila melanogaster (Fruit fly) 297 "apoptotic process [GO:0006915]; compound eye photoreceptor cell differentiation [GO:0001751]; embryo development [GO:0009790]; eye development [GO:0001654]; imaginal disc-derived wing morphogenesis [GO:0007476]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; peripheral nervous system development [GO:0007422]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of female receptivity [GO:0045924]; regulation of gene expression [GO:0010468]; response to stimulus [GO:0050896]; rhabdomere development [GO:0042052]; somatic muscle development [GO:0007525]; visual perception [GO:0007601]" GO:0000381; GO:0001654; GO:0001751; GO:0003676; GO:0003677; GO:0005634; GO:0005737; GO:0006915; GO:0007422; GO:0007476; GO:0007517; GO:0007525; GO:0007601; GO:0009790; GO:0010468; GO:0030018; GO:0031673; GO:0042052; GO:0045924; GO:0046716; GO:0046872; GO:0048471; GO:0050896 0 0 0 0 O42574 CHOYP_ISCW_ISCW009595.1.2 m.25596 sp ADRB1_XENLA 29.762 336 200 10 45 354 15 340 2.70E-34 138 ADRB1_XENLA reviewed Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) (x-BETA1AR) adrb1 Xenopus laevis (African clawed frog) 385 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of GTPase activity [GO:0043547]; positive regulation of heart contraction [GO:0045823] GO:0004940; GO:0005057; GO:0005088; GO:0005769; GO:0005886; GO:0016021; GO:0030819; GO:0043547; GO:0043950; GO:0045823; GO:0071880 0 0 0 PF00001; O70277 CHOYP_BRAFLDRAFT_71595.4.4 m.52748 sp TRIM3_RAT 26.829 123 86 3 60 179 622 743 2.70E-08 56.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P10994 CHOYP_ACT.22.27 m.58204 sp ACTS_PLEWA 80 115 23 0 1 115 11 125 2.70E-70 209 ACTS_PLEWA reviewed "Actin, alpha skeletal muscle (Fragment)" 0 Pleurodeles waltl (Iberian ribbed newt) 125 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P12451 CHOYP_LOC100634483.1.1 m.17092 sp POL_HV2SB 25.194 258 166 12 264 500 597 848 2.70E-07 58.5 POL_HV2SB reviewed Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.47) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] gag-pol Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2) 1462 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; suppression by virus of host gene expression [GO:0039657]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]; viral release from host cell [GO:0019076] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004533; GO:0005198; GO:0006310; GO:0008270; GO:0008289; GO:0015074; GO:0019013; GO:0019076; GO:0020002; GO:0039657; GO:0042025; GO:0046718; GO:0055036; GO:0072494; GO:0075713; GO:0075732 0 0 0 PF00540;PF00607;PF00552;PF02022;PF00075;PF00665;PF00077;PF00078;PF06815;PF06817;PF00098; P16157 CHOYP_AFUA_1G01020.14.50 m.23832 sp ANK1_HUMAN 33.764 696 435 7 44 719 82 771 2.70E-93 322 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P30568 CHOYP_FAF2.1.1 m.54271 sp GSTA_PLEPL 45.872 218 115 3 1 217 1 216 2.70E-64 202 GSTA_PLEPL reviewed Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta) 0 Pleuronectes platessa (European plaice) 225 0 GO:0004364; GO:0005737 0 0 0 PF14497;PF13417; P42577 CHOYP_FRIS.1.11 m.19612 sp FRIS_LYMST 84 100 16 0 1 100 1 100 2.70E-59 183 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P59083 CHOYP_LOC100366766.1.1 m.56292 sp PHP14_PIG 48.387 124 56 2 17 134 5 126 2.70E-36 124 PHP14_PIG reviewed 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) PHPT1 PHP14 Sus scrofa (Pig) 126 peptidyl-histidine dephosphorylation [GO:0035971] GO:0004721; GO:0005829; GO:0008969; GO:0035971 0 0 0 0 Q01484 CHOYP_LOC753709.3.44 m.10352 sp ANK2_HUMAN 31.412 347 200 9 4 340 134 452 2.70E-35 143 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q06520 CHOYP_ST1B1.2.4 m.41256 sp ST2A1_HUMAN 29.798 198 121 8 10 197 4 193 2.70E-20 89 ST2A1_HUMAN reviewed Bile salt sulfotransferase (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (ST2A3) (Sulfotransferase 2A1) (ST2A1) SULT2A1 HST STD Homo sapiens (Human) 285 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; bile acid catabolic process [GO:0030573]; digestion [GO:0007586]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923] GO:0004062; GO:0004304; GO:0005737; GO:0005829; GO:0007586; GO:0008146; GO:0008202; GO:0030573; GO:0047704; GO:0050294; GO:0050427; GO:0051923 0 0 0 PF00685; Q0VAA2 CHOYP_NEMVEDRAFT_V1G212934.1.1 m.27538 sp LR74A_HUMAN 33.43 344 209 5 119 461 46 370 2.70E-43 165 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q148E1 CHOYP_APOP1.1.1 m.7221 sp APOP1_BOVIN 48.201 139 69 1 51 186 45 183 2.70E-40 138 APOP1_BOVIN reviewed "Apoptogenic protein 1, mitochondrial (APOP-1)" APOPT1 APOP1 Bos taurus (Bovine) 192 intrinsic apoptotic signaling pathway [GO:0097193]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of smooth muscle cell apoptotic process [GO:0034393] GO:0005739; GO:0034393; GO:0043280; GO:0090200; GO:0097193 0 0 0 PF10231; Q24307 CHOYP_BIRC7.4.5 m.33631 sp DIAP2_DROME 23.81 441 267 12 40 449 95 497 2.70E-27 117 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q25010 CHOYP_ACTA.1.2 m.13067 sp ACT3A_HELAM 83.516 273 24 2 4 276 97 348 2.70E-163 464 ACT3A_HELAM reviewed "Actin, cytoplasmic A3a" actA3a Helicoverpa armigera (Cotton bollworm) (Heliothis armigera) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q2KI52 CHOYP_BRAFLDRAFT_79227.1.1 m.15952 sp HYLS1_BOVIN 37.054 224 100 8 117 301 82 303 2.70E-27 111 HYLS1_BOVIN reviewed Hydrolethalus syndrome protein 1 homolog HYLS1 Bos taurus (Bovine) 314 0 GO:0005634; GO:0005737; GO:0005813; GO:0005886 0 0 0 PF15311; Q4ZJM9 CHOYP_LOC100698439.2.2 m.44695 sp C1QL4_MOUSE 35.484 93 57 2 13 103 123 214 2.70E-08 53.1 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q566U4 CHOYP_LOC100709900.1.1 m.46464 sp KFA_DANRE 36.301 292 182 2 6 297 4 291 2.70E-74 233 KFA_DANRE reviewed Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) afmid zgc:112472 Danio rerio (Zebrafish) (Brachydanio rerio) 293 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0004061; GO:0005634; GO:0005829; GO:0019441; GO:0034354 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03014}. 0 0 PF07859; Q5UQ88 CHOYP_ZYRO0F11880G.1.1 m.7082 sp UBC3_MIMIV 40.645 155 81 6 145 288 396 550 2.70E-10 64.7 UBC3_MIMIV reviewed Probable ubiquitin-conjugating enzyme E2 R521 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R521) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) MIMI_R521 Acanthamoeba polyphaga mimivirus (APMV) 1441 protein ubiquitination [GO:0016567] GO:0005524; GO:0016021; GO:0016567; GO:0016740 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q5UR67 CHOYP_contig_051394 m.61415 sp RIBX_MIMIV 46.061 165 78 3 332 485 2 166 2.70E-34 130 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5ZKJ4 CHOYP_LOC100010019.1.1 m.12828 sp FGOP2_CHICK 58.242 182 73 2 1 179 3 184 2.70E-66 207 FGOP2_CHICK reviewed FGFR1 oncogene partner 2 homolog FGFR1OP2 RCJMB04_10g7 Gallus gallus (Chicken) 217 wound healing [GO:0042060] GO:0005737; GO:0042060 0 0 0 PF05769; Q66KY3 CHOYP_DANA_GF15955.1.1 m.44177 sp CUTA_XENLA 55.769 104 46 0 77 180 46 149 2.70E-35 124 CUTA_XENLA reviewed Protein CutA homolog cuta Xenopus laevis (African clawed frog) 151 response to metal ion [GO:0010038] GO:0010038 0 0 0 PF03091; Q6P9K8 CHOYP_ACA1_126310.1.1 m.15443 sp CSKI1_MOUSE 39.286 112 52 2 281 380 114 221 2.70E-15 81.3 CSKI1_MOUSE reviewed Caskin-1 (CASK-interacting protein 1) Caskin1 Kiaa1306 Mus musculus (Mouse) 1431 signal transduction [GO:0007165] GO:0005737; GO:0007165 0 0 0 PF12796;PF16632;PF00536;PF07653; Q6XIM8 CHOYP_RS15A.9.11 m.37727 sp RS15A_DROYA 85.271 129 17 1 1 127 1 129 2.70E-79 233 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q7Z6M2 CHOYP_LOC100376767.1.1 m.49886 sp FBX33_HUMAN 27.846 492 269 16 43 469 67 537 2.70E-40 155 FBX33_HUMAN reviewed F-box only protein 33 FBXO33 FBX33 Homo sapiens (Human) 555 protein ubiquitination [GO:0016567] GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; Q86WZ6 CHOYP_ZN184.2.4 m.13566 sp ZN227_HUMAN 41.818 385 224 0 451 835 406 790 2.70E-93 315 ZN227_HUMAN reviewed Zinc finger protein 227 ZNF227 Homo sapiens (Human) 799 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q8I7P9 CHOYP_CRE_23798.1.1 m.1744 sp POL5_DROME 41.117 197 104 3 1 186 289 484 2.70E-41 151 POL5_DROME reviewed Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1003 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003676; GO:0003964; GO:0004519; GO:0005634; GO:0006313; GO:0008233; GO:0015074 0 0 0 PF00665;PF00078; Q8K1C7 CHOYP_LOC409131.1.2 m.52387 sp MOT14_MOUSE 30.769 520 315 9 35 548 31 511 2.70E-73 245 MOT14_MOUSE reviewed Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) Slc16a14 Mct14 Mus musculus (Mouse) 512 0 GO:0005886; GO:0008028; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q90Z00 CHOYP_BRAFLDRAFT_86594.1.1 m.38765 sp FGR1A_DANRE 42.296 331 152 5 1 329 489 782 2.70E-77 260 FGR1A_DANRE reviewed Fibroblast growth factor receptor 1-A (FGFR-1-A) (bFGF-R-1-A) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1-A) fgfr1a fgfr1 si:ch211-198o12.1 Danio rerio (Zebrafish) (Brachydanio rerio) 810 anatomical structure homeostasis [GO:0060249]; cardiac muscle tissue development [GO:0048738]; dorsal/ventral pattern formation [GO:0009953]; fibroblast growth factor receptor signaling pathway [GO:0008543]; fin regeneration [GO:0031101]; liver development [GO:0001889]; negative regulation of endodermal cell fate specification [GO:0042664]; olfactory nerve formation [GO:0021628]; olfactory placode morphogenesis [GO:0071699]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell proliferation [GO:0008284]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phospholipase C activity [GO:0010863]; post-anal tail morphogenesis [GO:0036342]; posterior lateral line development [GO:0048916]; response to ethanol [GO:0045471]; skin morphogenesis [GO:0043589] GO:0001889; GO:0005007; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0005887; GO:0008201; GO:0008284; GO:0008543; GO:0009953; GO:0010863; GO:0016023; GO:0017134; GO:0018108; GO:0021628; GO:0031101; GO:0036342; GO:0042664; GO:0043406; GO:0043589; GO:0045471; GO:0048738; GO:0048916; GO:0060249; GO:0071699 0 0 0 PF07679;PF07714; Q95VY2 CHOYP_SF3A1.1.3 m.41532 sp TCTP_BRABE 51.149 174 80 3 21 194 1 169 2.70E-56 178 TCTP_BRABE reviewed Translationally-controlled tumor protein homolog (TCTP) 0 Branchiostoma belcheri (Amphioxus) 169 0 GO:0005737 0 0 0 PF00838; Q9BXW9 CHOYP_FANCD2.1.1 m.19557 sp FACD2_HUMAN 42.069 435 230 9 20 443 16 439 2.70E-100 330 FACD2_HUMAN reviewed Fanconi anemia group D2 protein (Protein FACD2) FANCD2 FACD Homo sapiens (Human) 1451 gamete generation [GO:0007276]; interstrand cross-link repair [GO:0036297]; response to gamma radiation [GO:0010332]; synapsis [GO:0007129] GO:0000793; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007129; GO:0007276; GO:0010332; GO:0036297; GO:0070182 0 0 0 PF14631; Q9H9E1 CHOYP_ANRA2.1.1 m.10771 sp ANRA2_HUMAN 41.921 229 120 3 43 259 82 309 2.70E-50 170 ANRA2_HUMAN reviewed Ankyrin repeat family A protein 2 (RFXANK-like protein 2) ANKRA2 ANKRA Homo sapiens (Human) 313 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0003712; GO:0005634; GO:0005829; GO:0005856; GO:0006357; GO:0016020; GO:0030169 0 0 0 PF12796; Q9W6Z2 CHOYP_PHUM_PHUM375280.2.2 m.56484 sp TBPL1_XENLA 63.372 172 63 0 47 218 9 180 2.70E-76 233 TBPL1_XENLA reviewed TATA box-binding protein-like protein 1 (TBP-like protein 1) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (xlTLF) tbpl1 tlf trf2 Xenopus laevis (African clawed frog) 186 "DNA-templated transcription, initiation [GO:0006352]; embryo development [GO:0009790]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003677; GO:0005634; GO:0005737; GO:0006352; GO:0006355; GO:0006366; GO:0009790 0 0 cd04517; PF00352; A1L253 CHOYP_BRAFLDRAFT_130640.1.1 m.36722 sp F149B_DANRE 31.653 496 270 20 128 581 89 557 2.71E-39 157 F149B_DANRE reviewed Protein FAM149B1 fam149b1 zgc:158651 Danio rerio (Zebrafish) (Brachydanio rerio) 644 0 0 0 0 0 PF12516; D3YXG0 CHOYP_LOC100210677.7.8 m.42871 sp HMCN1_MOUSE 47.801 341 178 0 882 1222 4527 4867 2.71E-98 351 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; D8VNS8 CHOYP_BRAFLDRAFT_59661.4.6 m.60012 sp FCNV2_CERRY 53.548 155 68 2 89 242 130 281 2.71E-51 173 FCNV2_CERRY reviewed Ryncolin-2 0 Cerberus rynchops (Dog-faced water snake) 347 0 GO:0005576 0 0 0 PF01391;PF00147; G5E8K5 CHOYP_AASI_1435.32.35 m.63684 sp ANK3_MOUSE 23.077 351 234 9 272 618 305 623 2.71E-18 93.2 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; H2A0L0 CHOYP_TYRO1.5.6 m.44175 sp TYRO1_PINMG 27.934 426 243 16 15 405 11 407 2.71E-31 131 TYRO1_PINMG reviewed Tyrosinase-like protein 1 (EC 1.14.18.-) (Tyrosinase 1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 492 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; O14514 CHOYP_CELR2.2.8 m.2728 sp BAI1_HUMAN 25.068 738 480 21 160 854 488 1195 2.71E-57 219 BAI1_HUMAN reviewed Brain-specific angiogenesis inhibitor 1 BAI1 Homo sapiens (Human) 1584 axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell proliferation [GO:0008285]; peripheral nervous system development [GO:0007422]; positive regulation of synapse assembly [GO:0051965]; signal transduction [GO:0007165] GO:0004930; GO:0005886; GO:0005887; GO:0005911; GO:0007155; GO:0007165; GO:0007166; GO:0007186; GO:0007409; GO:0007422; GO:0008285; GO:0014069; GO:0016021; GO:0016525; GO:0051965 0 0 0 PF00002;PF16489;PF01825;PF02793;PF00090; O17320 CHOYP_ACT.16.27 m.44915 sp ACT_CRAGI 98.039 102 2 0 1 102 244 345 2.71E-67 212 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P02877 CHOYP_HEVE.1.1 m.25859 sp HEVE_HEVBR 98.529 204 3 0 5 208 1 204 2.71E-149 415 HEVE_HEVBR reviewed Pro-hevein (Major hevein) [Cleaved into: Hevein (allergen Hev b 6); Win-like protein] HEV1 Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis) 204 defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832] GO:0008061; GO:0042742; GO:0050832 0 0 0 PF00967;PF00187; P04323 CHOYP_LOC100329443.1.1 m.17912 sp POL3_DROME 49.457 184 88 3 2 185 446 624 2.71E-45 162 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P05099 CHOYP_LOC100636433.1.4 m.4574 sp MATN1_CHICK 28.649 185 127 2 179 362 269 449 2.71E-15 83.2 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P09206 CHOYP_LOC373275.5.7 m.49534 sp TBB3_CHICK 51.389 144 43 4 6 144 53 174 2.71E-26 106 TBB3_CHICK reviewed Tubulin beta-3 chain (Beta-tubulin class-IV) 0 Gallus gallus (Chicken) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P09892 CHOYP_contig_038478 m.43530 sp SCP_APLCA 30.952 126 64 6 3 120 5 115 2.71E-06 46.6 SCP_APLCA reviewed Small cardioactive peptides [Cleaved into: Small cardioactive peptide B (SCP B); Small cardioactive peptide A (SCP A)] 0 Aplysia californica (California sea hare) 136 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 0 P0AGE8 CHOYP_TRIADDRAFT_64314.2.2 m.54695 sp CHRR_SHIFL 28.426 197 125 6 35 227 4 188 2.71E-08 55.5 CHRR_SHIFL reviewed Chromate reductase (CHRR) (EC 1.6.5.2) (NAD(P)H dehydrogenase (quinone)) chrR yieF SF3747 S4025 Shigella flexneri 188 0 GO:0003955 0 0 0 PF03358; P10079 CHOYP_LOC575027.4.6 m.37963 sp FBP1_STRPU 54.81 343 153 2 110 452 216 556 2.71E-114 369 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P13497 CHOYP_LOC100176320.1.1 m.50999 sp BMP1_HUMAN 27.869 122 80 2 154 272 743 859 2.71E-07 57 BMP1_HUMAN reviewed Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) BMP1 PCOLC Homo sapiens (Human) 986 BMP signaling pathway [GO:0030509]; cartilage condensation [GO:0001502]; cell development [GO:0048468]; extracellular matrix disassembly [GO:0022617]; lipoprotein metabolic process [GO:0042157]; multicellular organism development [GO:0007275]; ossification [GO:0001503]; positive regulation of cartilage development [GO:0061036]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of MAPK cascade [GO:0043408]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395] GO:0001501; GO:0001502; GO:0001503; GO:0004222; GO:0004252; GO:0005125; GO:0005160; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005794; GO:0006508; GO:0007275; GO:0008233; GO:0008237; GO:0008270; GO:0010862; GO:0022617; GO:0030509; GO:0031988; GO:0042157; GO:0042981; GO:0043408; GO:0048468; GO:0060395; GO:0061036 0 0 0 PF01400;PF00431;PF07645; P15428 CHOYP_PGDH.5.5 m.66725 sp PGDH_HUMAN 41.502 253 133 2 2 239 3 255 2.71E-61 196 PGDH_HUMAN reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) (Short chain dehydrogenase/reductase family 36C member 1) HPGD PGDH1 SDR36C1 Homo sapiens (Human) 266 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; lipoxin metabolic process [GO:2001300]; lipoxygenase pathway [GO:0019372]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005654; GO:0005737; GO:0005829; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0019372; GO:0030728; GO:0042803; GO:0045786; GO:0051287; GO:0070062; GO:0070403; GO:0070493; GO:0097070; GO:2001300 0 0 0 PF00106; P18433 CHOYP_MEGF6.32.59 m.41698 sp PTPRA_HUMAN 33.081 396 211 11 504 889 136 487 2.71E-54 206 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P22674 CHOYP_LOC100562732.1.1 m.14830 sp CCNO_HUMAN 39.691 194 116 1 115 308 94 286 2.71E-37 140 CCNO_HUMAN reviewed Cyclin-O CCNO Homo sapiens (Human) 350 base-excision repair [GO:0006284]; cell cycle [GO:0007049]; cell division [GO:0051301]; cilium assembly [GO:0042384]; multi-ciliated epithelial cell differentiation [GO:1903251]; response to drug [GO:0042493] GO:0004844; GO:0005654; GO:0005737; GO:0006284; GO:0007049; GO:0042384; GO:0042493; GO:0051301; GO:1903251 0 0 0 PF02984;PF00134; P22770 CHOYP_LOC101363826.1.1 m.22258 sp ACHA7_CHICK 28.92 287 195 3 28 309 33 315 2.71E-44 162 ACHA7_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 Gallus gallus (Chicken) 502 "activation of MAPK activity [GO:0000187]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; cognition [GO:0050890]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0000187; GO:0001540; GO:0001666; GO:0004889; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0030054; GO:0030424; GO:0030425; GO:0032720; GO:0035094; GO:0042166; GO:0042803; GO:0043204; GO:0045211; GO:0045766; GO:0050890 0 0 0 PF02931;PF02932; P27080 CHOYP_LOC100633390.1.5 m.9939 sp ADT_CHLRE 45.296 287 156 1 36 322 12 297 2.71E-86 265 ADT_CHLRE reviewed "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" ABT Chlamydomonas reinhardtii (Chlamydomonas smithii) 308 transmembrane transport [GO:0055085] GO:0005215; GO:0005743; GO:0016021; GO:0055085 0 0 0 PF00153; P33609 CHOYP_contig_056314 m.66867 sp DPOLA_MOUSE 31.667 120 70 5 7 126 120 227 2.71E-06 49.7 DPOLA_MOUSE reviewed DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) Pola1 Pola Mus musculus (Mouse) 1465 cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair via nonhomologous end joining [GO:0006303]; lagging strand elongation [GO:0006273]; leading strand elongation [GO:0006272] GO:0000166; GO:0000785; GO:0001882; GO:0003677; GO:0003682; GO:0003887; GO:0003896; GO:0005634; GO:0005635; GO:0005654; GO:0005658; GO:0005730; GO:0005737; GO:0006260; GO:0006270; GO:0006271; GO:0006272; GO:0006273; GO:0006303; GO:0008283; GO:0008408; GO:0016363; GO:0019901; GO:0046872; GO:0046982; GO:0051539 0 0 0 PF12254;PF00136;PF03104;PF08996; P80601 CHOYP_BRAFLDRAFT_118789.1.3 m.21275 sp UK114_CAPHI 68.182 132 42 0 35 166 1 132 2.71E-59 184 UK114_CAPHI reviewed Ribonuclease UK114 (EC 3.1.-.-) (14.3 kDa perchloric acid soluble protein) (14.5 kDa translational inhibitor protein) (UK114 antigen) HRSP12 Capra hircus (Goat) 137 0 GO:0004519; GO:0009986 0 0 0 PF01042; Q0IHY5 CHOYP_LOC100367640.1.1 m.22070 sp EMC7_XENTR 48.876 178 91 0 77 254 38 215 2.71E-61 196 EMC7_XENTR reviewed ER membrane protein complex subunit 7 emc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 237 0 GO:0016021; GO:0072546 0 0 0 PF09430; Q14790 CHOYP_BRAFLDRAFT_194931.1.1 m.46966 sp CASP8_HUMAN 45.85 253 128 5 490 735 226 476 2.71E-56 202 CASP8_HUMAN reviewed Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) 479 activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cell surface receptor signaling pathway [GO:0007166]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; death-inducing signaling complex assembly [GO:0071550]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; macrophage differentiation [GO:0030225]; natural killer cell activation [GO:0030101]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of proteolysis [GO:0045862]; protein heterooligomerization [GO:0051291]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of necrotic cell death [GO:0010939]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to cold [GO:0009409]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process [GO:0039650]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell activation [GO:0042110]; TRAIL-activated apoptotic signaling pathway [GO:0036462]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] GO:0004197; GO:0005654; GO:0005737; GO:0005739; GO:0005741; GO:0005815; GO:0005829; GO:0005856; GO:0006508; GO:0006915; GO:0006919; GO:0006921; GO:0007166; GO:0008233; GO:0008234; GO:0009409; GO:0010803; GO:0010939; GO:0030101; GO:0030225; GO:0031264; GO:0031265; GO:0031625; GO:0032025; GO:0032355; GO:0032496; GO:0034612; GO:0035666; GO:0035877; GO:0036462; GO:0039650; GO:0042110; GO:0042113; GO:0042802; GO:0043005; GO:0043123; GO:0043124; GO:0044297; GO:0045121; GO:0045471; GO:0045651; GO:0045862; GO:0046677; GO:0051291; GO:0051603; GO:0060715; GO:0070423; GO:0071260; GO:0071407; GO:0071550; GO:0097110; GO:0097153; GO:0097190; GO:0097191; GO:0097194; GO:0097199; GO:0097202; GO:0097296; GO:0097342; GO:1900740; GO:1902041; GO:1902042 0 0 0 PF01335; Q4R707 CHOYP_SPIRE1.1.1 m.50253 sp SPIR1_MACFA 39.817 437 207 9 204 586 37 471 2.71E-85 283 SPIR1_MACFA reviewed Protein spire homolog 1 SPIRE1 QtsA-16668 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 584 actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005829; GO:0005856; GO:0005886; GO:0005938; GO:0015031; GO:0016192; GO:0030036; GO:0030659; GO:0036089; GO:0040038; GO:0045010; GO:0046907; GO:0048471; GO:0051295; GO:0070649 0 0 0 PF16474; Q504N0 CHOYP_LOC100746520.1.1 m.29979 sp CBPA2_MOUSE 38.584 438 239 9 12 446 3 413 2.71E-101 311 CBPA2_MOUSE reviewed Carboxypeptidase A2 (EC 3.4.17.15) Cpa2 Mus musculus (Mouse) 417 0 GO:0004180; GO:0004181; GO:0005576; GO:0005615; GO:0008270 0 0 0 PF00246;PF02244; Q5G265 CHOYP_LOC100633732.1.3 m.2232 sp NETR_SAGLB 45.018 271 137 5 1 263 304 570 2.71E-73 243 NETR_SAGLB reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Saguinus labiatus (Red-chested mustached tamarin) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5ZIJ9 CHOYP_MIB2.4.6 m.43287 sp MIB2_CHICK 34.464 914 529 14 1 892 9 874 2.71E-175 536 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q68LP1 CHOYP_MIB2.1.6 m.6006 sp MIB2_RAT 30.46 174 99 4 5 166 321 484 2.71E-18 84.3 MIB2_RAT reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (RBSC-skeletrophin/dystrophin-like polypeptide) Mib2 Rattus norvegicus (Rat) 971 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0005768; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6DFJ6 CHOYP_IKK-EPSILON.1.3 m.25674 sp TBK1_XENLA 33.187 455 275 7 15 454 1 441 2.71E-77 266 TBK1_XENLA reviewed Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) tbk1 Xenopus laevis (African clawed frog) 725 innate immune response [GO:0045087] GO:0004674; GO:0005524; GO:0005737; GO:0045087 0 0 0 PF00069; Q6IR42 CHOYP_LOC100879901.1.1 m.46056 sp ZCPW1_MOUSE 35.573 253 155 4 417 667 175 421 2.71E-37 153 ZCPW1_MOUSE reviewed Zinc finger CW-type PWWP domain protein 1 Zcwpw1 Gm1053 Mus musculus (Mouse) 630 0 GO:0008270 0 0 0 PF00855;PF07496; Q6PAF4 CHOYP_LOC100373071.2.2 m.43112 sp NSE1_XENLA 40.586 239 133 3 3 241 4 233 2.71E-58 198 NSE1_XENLA reviewed Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 6.3.2.-) nsmce1 Xenopus laevis (African clawed frog) 270 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of response to DNA damage stimulus [GO:2001022] GO:0000781; GO:0004842; GO:0005634; GO:0006281; GO:0006310; GO:0016874; GO:0030915; GO:0046872; GO:2001022 0 0 0 PF07574;PF08746; Q6R5N8 CHOYP_LOC100222593.1.1 m.31345 sp TLR13_MOUSE 24.872 784 486 32 36 748 226 977 2.71E-30 132 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q8IVU9 CHOYP_LOC100378886.2.2 m.22950 sp CJ107_HUMAN 34.259 216 116 3 86 286 3 207 2.71E-31 120 CJ107_HUMAN reviewed Uncharacterized protein C10orf107 C10orf107 Homo sapiens (Human) 208 0 0 0 0 0 PF14769; Q8WZ42 CHOYP_TITIN.13.19 m.52186 sp TITIN_HUMAN 30.172 1624 928 42 45 1584 942 2443 2.71E-173 609 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q92982 CHOYP_NINJ2.1.1 m.30699 sp NINJ1_HUMAN 40 110 65 1 10 118 32 141 2.71E-21 85.9 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q99NH0 CHOYP_AASI_1435.2.35 m.17918 sp ANR17_MOUSE 30.788 406 245 13 76 448 248 650 2.71E-35 143 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BWV1 CHOYP_BOC.1.1 m.27955 sp BOC_HUMAN 26.367 713 445 24 3 671 17 693 2.71E-49 194 BOC_HUMAN reviewed Brother of CDO (Protein BOC) BOC UNQ604/PRO1190 Homo sapiens (Human) 1114 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; smoothened signaling pathway [GO:0007224] GO:0005886; GO:0005887; GO:0007155; GO:0007224; GO:0007411; GO:0044295; GO:0045663; GO:0051149; GO:0098779 0 0 0 PF00041;PF07679;PF00047; Q9D4B2 CHOYP_TTC25.1.1 m.55748 sp TTC25_MOUSE 39.462 223 135 0 599 821 271 493 2.71E-44 174 TTC25_MOUSE reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) Ttc25 Mus musculus (Mouse) 624 0 GO:0005737 0 0 0 PF13181; Q9DAT2 CHOYP_LOC588659.1.1 m.13872 sp MRGBP_MOUSE 38.889 180 91 6 86 253 31 203 2.71E-28 109 MRGBP_MOUSE reviewed MRG/MORF4L-binding protein (MRG-binding protein) Mrgbp Mus musculus (Mouse) 204 "histone acetylation [GO:0016573]; regulation of growth [GO:0040008]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006357; GO:0016573; GO:0035267; GO:0040008 0 0 0 PF07904; Q9GZT4 CHOYP_DAR1.2.4 m.29583 sp SRR_HUMAN 46.97 330 156 8 1 321 1 320 2.71E-94 286 SRR_HUMAN reviewed Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) SRR Homo sapiens (Human) 340 aging [GO:0007568]; brain development [GO:0007420]; D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; pyruvate biosynthetic process [GO:0042866]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to morphine [GO:0043278]; serine family amino acid metabolic process [GO:0009069] GO:0000287; GO:0003941; GO:0005509; GO:0005524; GO:0005737; GO:0005886; GO:0006563; GO:0007420; GO:0007568; GO:0008721; GO:0009069; GO:0016594; GO:0018114; GO:0030165; GO:0030170; GO:0030378; GO:0032496; GO:0042493; GO:0042803; GO:0042866; GO:0043025; GO:0043278; GO:0045177; GO:0051289; GO:0070178; GO:0070179 0 0 0 PF00291; Q9H853 CHOYP_TBA1.7.9 m.44113 sp TBA4B_HUMAN 84.337 83 13 0 15 97 137 219 2.71E-42 141 TBA4B_HUMAN reviewed Putative tubulin-like protein alpha-4B (Alpha-tubulin 4B) TUBA4B TUBA4 Homo sapiens (Human) 241 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091; Q9R1R2 CHOYP_BRAFLDRAFT_205965.24.43 m.46263 sp TRIM3_MOUSE 27.215 158 100 5 106 257 595 743 2.71E-09 63.9 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UGM3 CHOYP_DMBT1.23.34 m.47538 sp DMBT1_HUMAN 41.532 679 291 14 3 585 186 854 2.71E-137 456 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9VAQ5 CHOYP_BRAFLDRAFT_225323.1.1 m.38605 sp DIM1_DROME 72.222 306 85 0 1 306 1 306 2.71E-170 477 DIM1_DROME reviewed "Probable dimethyladenosine transferase (EC 2.1.1.183) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)" CG11837 Drosophila melanogaster (Fruit fly) 306 neurogenesis [GO:0022008]; sleep [GO:0030431] GO:0000179; GO:0003723; GO:0005730; GO:0005759; GO:0022008; GO:0030431; GO:0052909 0 0 0 PF00398; Q9VMY1 CHOYP_LOC100879807.1.1 m.14598 sp RM24_DROME 40.86 186 99 4 65 245 68 247 2.71E-35 129 RM24_DROME reviewed "Probable 39S ribosomal protein L24, mitochondrial (L24mt) (MRP-L24)" mRpL24 CG8849 Drosophila melanogaster (Fruit fly) 247 sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005762; GO:0006412; GO:0019233 0 0 0 PF00467;PF17136; A2AX52 CHOYP_LOC100030437.2.3 m.17964 sp CO6A4_MOUSE 23.4 547 367 13 252 787 202 707 2.72E-42 171 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A2TJ54 CHOYP_BRAFLDRAFT_220284.1.1 m.29545 sp CLN5_SHEEP 50.987 304 137 6 36 332 54 352 2.72E-106 318 CLN5_SHEEP reviewed Ceroid-lipofuscinosis neuronal protein 5 (Protein CLN5) CLN5 Ovis aries (Sheep) 361 glycosylation [GO:0070085]; neurogenesis [GO:0022008]; signal peptide processing [GO:0006465] GO:0005537; GO:0005764; GO:0006465; GO:0022008; GO:0070085 0 0 0 PF15014; A4IF63 CHOYP_LOC100375551.2.2 m.63719 sp TRIM2_BOVIN 24.034 233 164 4 308 538 523 744 2.72E-09 63.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8Y1P7 CHOYP_LOC100906882.1.1 m.5196 sp BRE4_CAEBR 42.545 275 154 2 30 300 92 366 2.72E-74 235 BRE4_CAEBR reviewed "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 CBG22165 Caenorhabditis briggsae 384 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0016757; GO:0046872 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9GUM2}. 0 0 PF02709;PF13733; D2GXS7 CHOYP_LOC100374741.5.83 m.3229 sp TRIM2_AILME 22.368 228 117 6 294 500 468 656 2.72E-08 60.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15519 CHOYP_RL23A.1.6 m.848 sp CFLAR_HUMAN 33.663 202 110 4 23 222 3 182 2.72E-16 81.6 CFLAR_HUMAN reviewed CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] CFLAR CASH CASP8AP1 CLARP MRIT Homo sapiens (Human) 480 apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of myoblast fusion [GO:1901740]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of necroptotic process [GO:0060544]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; skeletal muscle atrophy [GO:0014732]; skeletal muscle tissue development [GO:0007519]; skeletal muscle tissue regeneration [GO:0043403]; skeletal myofibril assembly [GO:0014866]; viral process [GO:0016032] GO:0002020; GO:0005737; GO:0005829; GO:0006915; GO:0007519; GO:0008047; GO:0014732; GO:0014842; GO:0014866; GO:0016032; GO:0031264; GO:0031265; GO:0043066; GO:0043123; GO:0043403; GO:0045121; GO:0051092; GO:0060544; GO:0097194; GO:0097200; GO:0097342; GO:1901740; GO:1902041; GO:1902042; GO:2001237 0 0 0 PF01335; O15973 CHOYP_BRAFLDRAFT_121525.1.1 m.59431 sp OPSD1_MIZYE 21.354 384 222 11 6 377 50 365 2.72E-16 84 OPSD1_MIZYE reviewed "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 499 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0004930; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; O75382 CHOYP_BRAFLDRAFT_87325.2.11 m.399 sp TRIM3_HUMAN 22.878 271 183 12 39 295 486 744 2.72E-07 55.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88281 CHOYP_MEGF6.57.59 m.61848 sp MEGF6_RAT 38.286 350 155 16 182 487 866 1198 2.72E-43 173 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O95149 CHOYP_LOC100086964.1.1 m.44646 sp SPN1_HUMAN 41.509 106 57 2 1 105 1 102 2.72E-18 81.6 SPN1_HUMAN reviewed Snurportin-1 (RNA U transporter 1) SNUPN RNUT1 SPN1 Homo sapiens (Human) 360 nuclear import [GO:0051170]; protein import into nucleus [GO:0006606]; snRNA import into nucleus [GO:0061015]; spliceosomal snRNP assembly [GO:0000387] GO:0000339; GO:0000387; GO:0005643; GO:0005829; GO:0006606; GO:0008565; GO:0051170; GO:0061015; GO:0070062 0 0 0 PF11538; P08548 CHOYP_DDB_G0292452.1.1 m.22166 sp LIN1_NYCCO 30.833 120 83 0 29 148 594 713 2.72E-11 63.9 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P32004 CHOYP_CNTN5.2.5 m.34361 sp L1CAM_HUMAN 25.432 405 244 18 40 417 48 421 2.72E-22 105 L1CAM_HUMAN reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) L1CAM CAML1 MIC5 Homo sapiens (Human) 1257 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; leukocyte migration [GO:0050900]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773] GO:0005886; GO:0005925; GO:0006935; GO:0007155; GO:0007399; GO:0007411; GO:0009986; GO:0016021; GO:0044295; GO:0045773; GO:0050900 0 0 0 PF13882;PF00041;PF07679; P52503 CHOYP_ACT3A.1.1 m.25943 sp NDUS6_MOUSE 46.903 113 56 3 1 111 1 111 2.72E-27 100 NDUS6_MOUSE reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)" Ndufs6 Ip13 Mus musculus (Mouse) 116 "cardiovascular system development [GO:0072358]; fatty acid metabolic process [GO:0006631]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrion morphogenesis [GO:0070584]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; muscle contraction [GO:0006936]; reproductive system development [GO:0061458]; respiratory electron transport chain [GO:0022904]" GO:0005739; GO:0005747; GO:0006120; GO:0006631; GO:0006936; GO:0010259; GO:0022904; GO:0035264; GO:0061458; GO:0070584; GO:0072358 0 0 0 PF10276; P52503 CHOYP_ANXA7.2.4 m.30575 sp NDUS6_MOUSE 46.903 113 56 3 1 111 1 111 2.72E-27 100 NDUS6_MOUSE reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)" Ndufs6 Ip13 Mus musculus (Mouse) 116 "cardiovascular system development [GO:0072358]; fatty acid metabolic process [GO:0006631]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrion morphogenesis [GO:0070584]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; muscle contraction [GO:0006936]; reproductive system development [GO:0061458]; respiratory electron transport chain [GO:0022904]" GO:0005739; GO:0005747; GO:0006120; GO:0006631; GO:0006936; GO:0010259; GO:0022904; GO:0035264; GO:0061458; GO:0070584; GO:0072358 0 0 0 PF10276; P52503 CHOYP_LOC100159370.1.1 m.14589 sp NDUS6_MOUSE 46.903 113 56 3 1 111 1 111 2.72E-27 100 NDUS6_MOUSE reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)" Ndufs6 Ip13 Mus musculus (Mouse) 116 "cardiovascular system development [GO:0072358]; fatty acid metabolic process [GO:0006631]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrion morphogenesis [GO:0070584]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; muscle contraction [GO:0006936]; reproductive system development [GO:0061458]; respiratory electron transport chain [GO:0022904]" GO:0005739; GO:0005747; GO:0006120; GO:0006631; GO:0006936; GO:0010259; GO:0022904; GO:0035264; GO:0061458; GO:0070584; GO:0072358 0 0 0 PF10276; P52503 CHOYP_NEMVEDRAFT_V1G169611.1.1 m.25716 sp NDUS6_MOUSE 46.903 113 56 3 1 111 1 111 2.72E-27 100 NDUS6_MOUSE reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit)" Ndufs6 Ip13 Mus musculus (Mouse) 116 "cardiovascular system development [GO:0072358]; fatty acid metabolic process [GO:0006631]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrion morphogenesis [GO:0070584]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; muscle contraction [GO:0006936]; reproductive system development [GO:0061458]; respiratory electron transport chain [GO:0022904]" GO:0005739; GO:0005747; GO:0006120; GO:0006631; GO:0006936; GO:0010259; GO:0022904; GO:0035264; GO:0061458; GO:0070584; GO:0072358 0 0 0 PF10276; P55210 CHOYP_CASP7.23.23 m.66824 sp CASP7_HUMAN 31.304 230 125 9 63 274 87 301 2.72E-20 92 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P80311 CHOYP_LOC100374495.1.1 m.55368 sp PPIB_BOVIN 50.246 203 90 3 1 203 24 215 2.72E-56 181 PPIB_BOVIN reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Bos taurus (Bovine) 216 bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of multicellular organism growth [GO:0040018]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821] GO:0000413; GO:0003755; GO:0005634; GO:0005788; GO:0005925; GO:0016020; GO:0032403; GO:0032991; GO:0034663; GO:0040018; GO:0042277; GO:0042470; GO:0044822; GO:0044829; GO:0048471; GO:0050821; GO:0060348; GO:0061077; GO:0070062 0 0 0 PF00160; P83425 CHOYP_LOC100693208.5.8 m.5469 sp HIP_MYTED 36 100 63 1 137 235 82 181 2.72E-09 59.7 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P98158 CHOYP_LOC578599.4.8 m.37369 sp LRP2_RAT 30.588 255 166 5 20 267 1492 1742 2.72E-28 119 LRP2_RAT reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) 4660 aging [GO:0007568]; endosomal transport [GO:0016197]; hemoglobin import [GO:0020028]; hormone secretion [GO:0046879]; lipoprotein transport [GO:0042953]; negative regulation of endopeptidase activity [GO:0010951]; organ regeneration [GO:0031100]; receptor-mediated endocytosis [GO:0006898]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; transcytosis [GO:0045056]; vitamin metabolic process [GO:0006766] GO:0004872; GO:0005509; GO:0005615; GO:0005737; GO:0005768; GO:0005903; GO:0005905; GO:0006766; GO:0006898; GO:0007568; GO:0010165; GO:0010951; GO:0016020; GO:0016021; GO:0016197; GO:0016324; GO:0020028; GO:0030165; GO:0030492; GO:0031100; GO:0031526; GO:0032403; GO:0032526; GO:0033280; GO:0042493; GO:0042562; GO:0042953; GO:0043234; GO:0045056; GO:0045121; GO:0046879; GO:0050750 0 0 0 PF12662;PF07645;PF00057;PF00058; Q02290 CHOYP_LOC101426183.1.1 m.53925 sp XYNB_NEOPA 24.908 273 193 3 3 270 459 724 2.72E-18 89.4 XYNB_NEOPA reviewed "Endo-1,4-beta-xylanase B (Xylanase B) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase B)" xynB Neocallimastix patriciarum (Rumen fungus) 860 xylan catabolic process [GO:0045493] GO:0005576; GO:0030248; GO:0031176; GO:0045493 PATHWAY: Glycan degradation; xylan degradation. 0 0 PF00734;PF00331; Q06577 CHOYP_C1QT4.4.5 m.50539 sp HP27_TAMSI 30.952 126 76 3 222 340 93 214 2.72E-10 63.9 HP27_TAMSI reviewed Hibernation-associated plasma protein HP-27 (Hibernator-specific blood complex 27 kDa subunit) 0 Tamias sibiricus (Siberian chipmunk) (Eutamias sibiricus) 215 hibernation [GO:0042750] GO:0005576; GO:0005581; GO:0042750 0 0 0 PF00386;PF01391; Q06852 CHOYP_NEMVEDRAFT_V1G143109.2.2 m.53088 sp SLAP1_CLOTH 55.556 423 134 32 884 1257 1499 1916 2.72E-33 144 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0IIF0 CHOYP_BRAFLDRAFT_57823.1.1 m.12651 sp ILKAP_BOVIN 49.051 369 171 5 1 352 1 369 2.72E-122 360 ILKAP_BOVIN reviewed Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16) ILKAP Bos taurus (Bovine) 370 0 GO:0004722; GO:0005737; GO:0046872 0 0 0 PF00481; Q14766 CHOYP_NEMVEDRAFT_V1G32913.1.1 m.65240 sp LTBP1_HUMAN 32.813 256 132 13 6 240 1013 1249 2.72E-24 107 LTBP1_HUMAN reviewed Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) LTBP1 Homo sapiens (Human) 1721 aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; ventricular septum development [GO:0003281] GO:0001527; GO:0003281; GO:0005024; GO:0005509; GO:0005576; GO:0005578; GO:0031012; GO:0035583; GO:0035904; GO:0043234; GO:0050431; GO:0050436; GO:0060976 0 0 0 PF12662;PF07645;PF00683; Q17QK9 CHOYP_BRAFLDRAFT_225211.1.1 m.14895 sp NAA60_BOVIN 56 225 99 0 1 225 1 225 2.72E-91 271 NAA60_BOVIN reviewed N-alpha-acetyltransferase 60 (EC 2.3.1.48) (EC 2.3.1.88) (N-acetyltransferase 15) (NatF catalytic subunit) NAA60 NAT15 Bos taurus (Bovine) 242 cell proliferation [GO:0008283]; chromosome segregation [GO:0007059]; histone H4 acetylation [GO:0043967]; N-terminal peptidyl-methionine acetylation [GO:0017196]; nucleosome assembly [GO:0006334] GO:0000139; GO:0004596; GO:0006334; GO:0007059; GO:0008283; GO:0010485; GO:0017196; GO:0043967 0 0 0 PF00583; Q17QK9 CHOYP_NAA60.1.1 m.55747 sp NAA60_BOVIN 56 225 99 0 1 225 1 225 2.72E-91 271 NAA60_BOVIN reviewed N-alpha-acetyltransferase 60 (EC 2.3.1.48) (EC 2.3.1.88) (N-acetyltransferase 15) (NatF catalytic subunit) NAA60 NAT15 Bos taurus (Bovine) 242 cell proliferation [GO:0008283]; chromosome segregation [GO:0007059]; histone H4 acetylation [GO:0043967]; N-terminal peptidyl-methionine acetylation [GO:0017196]; nucleosome assembly [GO:0006334] GO:0000139; GO:0004596; GO:0006334; GO:0007059; GO:0008283; GO:0010485; GO:0017196; GO:0043967 0 0 0 PF00583; Q3SWX9 CHOYP_BRAFLDRAFT_275667.1.1 m.17354 sp RAD21_BOVIN 43.777 233 116 5 2 224 237 464 2.72E-37 146 RAD21_BOVIN reviewed Double-strand-break repair protein rad21 homolog RAD21 Bos taurus (Bovine) 630 apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168] GO:0000775; GO:0000785; GO:0001228; GO:0005654; GO:0006281; GO:0006915; GO:0007059; GO:0007067; GO:0016020; GO:0034991; GO:0051301; GO:0071168 0 0 0 PF04824;PF04825; Q53G44 CHOYP_RS4.5.11 m.30051 sp IF44L_HUMAN 41.667 84 49 0 5 88 350 433 2.72E-09 55.8 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5UNS9 CHOYP_CO4A1.2.2 m.42952 sp COLL7_MIMIV 46.552 232 124 0 113 344 666 897 2.72E-40 162 COLL7_MIMIV reviewed Collagen-like protein 7 MIMI_L669 Acanthamoeba polyphaga mimivirus (APMV) 1937 0 GO:0019012 0 0 0 PF01391; Q6GLJ1 CHOYP_BRAFLDRAFT_84585.1.1 m.15960 sp BTBDH_XENLA 25.974 462 296 12 17 458 27 462 2.72E-38 148 BTBDH_XENLA reviewed BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) 470 0 GO:0005576 0 0 0 PF07707;PF00651; Q6ZRF8 CHOYP_LOC100369754.5.10 m.43015 sp RN207_HUMAN 23.348 227 146 8 22 230 117 333 2.72E-07 57.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7T2H2 CHOYP_FGRL1.1.2 m.30547 sp FGRL1_CHICK 45.078 386 207 4 25 406 13 397 2.72E-110 339 FGRL1_CHICK reviewed Fibroblast growth factor receptor-like 1 FGFRL1 Gallus gallus (Chicken) 487 cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; heart valve morphogenesis [GO:0003179]; negative regulation of cell proliferation [GO:0008285]; protein homooligomerization [GO:0051260]; skeletal system development [GO:0001501]; ventricular septum morphogenesis [GO:0060412] GO:0001501; GO:0003179; GO:0005007; GO:0005794; GO:0005886; GO:0008201; GO:0008285; GO:0016021; GO:0030133; GO:0044291; GO:0051260; GO:0060412; GO:0098742 0 0 0 PF07679; Q86TX2 CHOYP_ACOT1.1.1 m.23846 sp ACOT1_HUMAN 37.931 406 233 9 16 412 16 411 2.72E-81 259 ACOT1_HUMAN reviewed Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.2) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) ACOT1 CTE1 Homo sapiens (Human) 421 acyl-CoA metabolic process [GO:0006637]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; very long-chain fatty acid metabolic process [GO:0000038] GO:0000038; GO:0001676; GO:0005829; GO:0006637; GO:0016290; GO:0035338; GO:0047617; GO:0052689 0 0 0 PF08840;PF04775; Q96L03 CHOYP_LOC576665.2.2 m.56832 sp SPT17_HUMAN 37.741 363 212 6 1 352 1 360 2.72E-77 244 SPT17_HUMAN reviewed Spermatogenesis-associated protein 17 SPATA17 Homo sapiens (Human) 361 0 GO:0005737 0 0 0 PF00612; Q96LQ0 CHOYP_LOC575437.1.1 m.45579 sp PPR36_HUMAN 29.95 404 238 9 21 409 7 380 2.72E-47 171 PPR36_HUMAN reviewed Protein phosphatase 1 regulatory subunit 36 PPP1R36 C14orf50 Homo sapiens (Human) 422 negative regulation of phosphatase activity [GO:0010923] GO:0004864; GO:0010923; GO:0019902 0 0 0 PF14895; Q9C040 CHOYP_ZF_BBOX_RING_-1.9.10 m.57514 sp TRIM2_HUMAN 25.333 225 157 5 269 490 525 741 2.72E-10 66.6 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9R0I6 CHOYP_TIAP2.3.13 m.29294 sp XIAP_RAT 33.594 128 75 3 273 400 366 483 2.72E-16 84 XIAP_RAT reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (rIAP-3) (rIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Api3 Birc4 Rattus norvegicus (Rat) 496 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] GO:0002020; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0008270; GO:0016055; GO:0016874; GO:0043027; GO:0043066; GO:0043234; GO:0043524; GO:0048471; GO:0090263; GO:0097110; GO:1990001 0 0 0 PF00653; Q9U489 CHOYP_LOC100213744.3.19 m.2322 sp LIN41_CAEEL 25.926 216 129 8 54 256 806 1003 2.72E-06 52 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9W636 CHOYP_DPF2.2.2 m.30875 sp REQUB_XENLA 81.308 107 20 0 36 142 247 353 2.72E-62 198 REQUB_XENLA reviewed Zinc finger protein ubi-d4 B (Apoptosis response zinc finger protein B) (Protein requiem B) (xReq B) (Fragment) req-b req2 Xenopus laevis (African clawed frog) 366 "apoptotic process [GO:0006915]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006915; GO:0008270 0 0 0 PF00628;PF14051; A4IF63 CHOYP_BRAFLDRAFT_87327.7.13 m.39254 sp TRIM2_BOVIN 25.806 155 100 4 31 181 600 743 2.73E-08 59.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O18783 CHOYP_PLMN.7.11 m.37204 sp PLMN_MACEU 36.224 588 270 22 457 975 4 555 2.73E-83 289 PLMN_MACEU reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macropus eugenii (Tammar wallaby) 806 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; O35226 CHOYP_LOC658092.2.2 m.60941 sp PSMD4_MOUSE 61.417 381 135 6 28 408 1 369 2.73E-151 436 PSMD4_MOUSE reviewed 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Multiubiquitin chain-binding protein) Psmd4 Mcb1 Mus musculus (Mouse) 376 proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0000502; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0008540; GO:0022624; GO:0031593; GO:0042802; GO:0043161; GO:0043248; GO:0044822 0 0 0 PF02809;PF13519; O43301 CHOYP_HSPA12A.11.27 m.36227 sp HS12A_HUMAN 30.137 584 339 20 401 924 12 586 2.73E-64 233 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_67265.1.1 m.3238 sp TRIM3_RAT 27.5 120 83 3 70 186 625 743 2.73E-07 53.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_71598.9.10 m.46253 sp TRIM3_RAT 26.316 152 107 3 37 184 593 743 2.73E-10 62 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75665 CHOYP_OFD1.1.1 m.29513 sp OFD1_HUMAN 32.175 777 448 17 7 768 12 724 2.73E-99 338 OFD1_HUMAN reviewed Oral-facial-digital syndrome 1 protein (Protein 71-7A) OFD1 CXorf5 Homo sapiens (Human) 1012 cilium morphogenesis [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; G2/M transition of mitotic cell cycle [GO:0000086] GO:0000086; GO:0005634; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0015630; GO:0016020; GO:0034451; GO:0036064; GO:0042802; GO:0043014; GO:0043015; GO:0060271; GO:0060287 0 0 0 PF16045; P09815 CHOYP_contig_005902 m.6752 sp ICEN_PSEFL 38.585 311 191 0 2 312 229 539 2.73E-17 86.3 ICEN_PSEFL reviewed Ice nucleation protein inaW Pseudomonas fluorescens 1210 0 GO:0009279; GO:0050825 0 0 0 PF00818; P0C7P0 CHOYP_ISCW_ISCW015396.1.1 m.41840 sp CISD3_HUMAN 44.318 88 42 4 25 110 41 123 2.73E-16 72.4 CISD3_HUMAN reviewed "CDGSH iron-sulfur domain-containing protein 3, mitochondrial (MitoNEET-related protein 2) (Miner2)" CISD3 Homo sapiens (Human) 127 0 GO:0005739; GO:0046872; GO:0051537 0 0 0 PF09360; P10079 CHOYP_DYAK_GE18383.1.1 m.31760 sp FBP1_STRPU 42.653 490 267 8 2360 2840 450 934 2.73E-106 372 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P18433 CHOYP_PTPRA.17.22 m.56651 sp PTPRA_HUMAN 30.015 683 444 19 342 1004 133 801 2.73E-80 281 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P23469 CHOYP_PTPRM.11.15 m.52054 sp PTPRE_HUMAN 31.177 603 378 16 574 1152 101 690 2.73E-77 273 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P42325 CHOYP_ASB3.1.1 m.51103 sp NCAH_DROME 41.969 193 100 4 1 185 1 189 2.73E-47 155 NCAH_DROME reviewed Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) 190 0 GO:0005509 0 0 0 PF00036;PF13499; P42325 CHOYP_NCAH.2.5 m.19892 sp NCAH_DROME 41.969 193 100 4 1 185 1 189 2.73E-47 155 NCAH_DROME reviewed Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) 190 0 GO:0005509 0 0 0 PF00036;PF13499; P86179 CHOYP_BRAFLDRAFT_67261.1.2 m.16694 sp CSL3_ONCKE 41.451 193 102 5 31 215 6 195 2.73E-37 131 CSL3_ONCKE reviewed L-rhamnose-binding lectin CSL3 0 Oncorhynchus keta (Chum salmon) (Salmo keta) 195 0 GO:0001674; GO:0005534; GO:0005623; GO:0005737; GO:0033296; GO:0042564; GO:0042803; GO:0060473; GO:1903777 0 0 0 PF02140; Q0P5B7 CHOYP_AAAD.1.4 m.4678 sp AAAD_BOVIN 31.188 404 236 17 56 442 8 386 2.73E-39 149 AAAD_BOVIN reviewed Arylacetamide deacetylase (EC 3.1.1.3) AADAC Bos taurus (Bovine) 399 metabolic process [GO:0008152]; positive regulation of triglyceride catabolic process [GO:0010898] GO:0004806; GO:0005789; GO:0008152; GO:0010898; GO:0016021; GO:0017171; GO:0031090 0 0 0 PF07859; Q14135 CHOYP_XBP1.1.4 m.28928 sp VGLL4_HUMAN 30.032 313 146 12 1 296 1 257 2.73E-15 78.6 VGLL4_HUMAN reviewed Transcription cofactor vestigial-like protein 4 (Vgl-4) VGLL4 KIAA0121 Homo sapiens (Human) 290 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF15245; Q2F637 CHOYP_14332.1.2 m.5643 sp 1433Z_BOMMO 66.031 262 74 2 19 280 1 247 2.73E-119 344 1433Z_BOMMO reviewed 14-3-3 protein zeta 14-3-3zeta Bombyx mori (Silk moth) 247 0 GO:0005737 0 0 0 PF00244; Q4QQM4 CHOYP_TP53I11.2.2 m.25168 sp P5I11_MOUSE 41.808 177 97 4 53 223 9 185 2.73E-36 129 P5I11_MOUSE reviewed Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) 189 0 GO:0016021 0 0 0 PF14936; Q4UKJ3 CHOYP_CNPV309.1.1 m.4465 sp Y1087_RICFE 41.429 70 41 0 575 644 22 91 2.73E-06 50.1 Y1087_RICFE reviewed Putative ankyrin repeat protein RF_1087 RF_1087 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 124 0 0 0 0 0 PF12796; Q5FVR2 CHOYP_NEMVEDRAFT_V1G241446.2.2 m.47394 sp TYPH_RAT 47.087 412 211 5 2 407 42 452 2.73E-118 357 TYPH_RAT reviewed Thymidine phosphorylase (TP) (EC 2.4.2.4) (TdRPase) Tymp Ecgf1 Rattus norvegicus (Rat) 476 pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; pyrimidine nucleotide metabolic process [GO:0006220] GO:0004645; GO:0005829; GO:0006206; GO:0006213; GO:0006220; GO:0009032; GO:0016154 PATHWAY: Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. 0 0 PF02885;PF00591;PF07831; Q60431 CHOYP_LOC100695417.1.2 m.4008 sp CASP3_MESAU 33.742 163 84 5 45 206 34 173 2.73E-15 79.3 CASP3_MESAU reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q69ZQ1 CHOYP_LOC100369529.1.1 m.13916 sp K1161_MOUSE 41.361 573 307 15 113 664 148 712 2.73E-144 440 K1161_MOUSE reviewed Uncharacterized family 31 glucosidase KIAA1161 (EC 3.2.1.-) Kiaa1161 Mus musculus (Mouse) 716 carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of protein kinase B signaling [GO:0051897]; skeletal muscle fiber development [GO:0048741] GO:0004553; GO:0005975; GO:0016021; GO:0031965; GO:0043568; GO:0048741; GO:0051897 0 0 0 PF01055; Q8BUV8 CHOYP_SMAG1.1.1 m.54363 sp GP107_MOUSE 42.984 563 255 14 16 572 33 535 2.73E-152 452 GP107_MOUSE reviewed Protein GPR107 Gpr107 Kiaa1624 Mus musculus (Mouse) 551 clathrin-mediated endocytosis [GO:0072583] GO:0005769; GO:0005794; GO:0016021; GO:0030136; GO:0032050; GO:0072583 0 0 0 PF06814; Q8BZG5 CHOYP_LOC101174860.1.1 m.1111 sp RRNAD_MOUSE 47.085 223 107 4 442 663 248 460 2.73E-53 193 RRNAD_MOUSE reviewed Protein RRNAD1 Rrnad1 Mus musculus (Mouse) 475 0 GO:0016021 0 0 0 PF13679; Q8K0U4 CHOYP_HSPA12A.19.27 m.54978 sp HS12A_MOUSE 33 300 191 7 5 299 379 673 2.73E-42 157 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8VDR5 CHOYP_LOC100077808.1.1 m.16427 sp CE028_MOUSE 44.186 172 85 3 25 190 30 196 2.73E-35 127 CE028_MOUSE reviewed Transmembrane protein C5orf28 homolog Gm7120 Mus musculus (Mouse) 215 0 GO:0016021 0 0 0 0 Q91145 CHOYP_LOC100709262.2.2 m.61235 sp COCA1_NOTVI 40.23 174 98 5 24 195 626 795 2.73E-30 120 COCA1_NOTVI reviewed Collagen alpha-1(XII) chain (Fragment) 0 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) 929 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF00041;PF00092; Q9BUE0 CHOYP_MED18.1.1 m.28719 sp MED18_HUMAN 55.959 193 79 4 18 209 20 207 2.73E-69 213 MED18_HUMAN reviewed Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b) MED18 Homo sapiens (Human) 208 termination of RNA polymerase II transcription [GO:0006369] GO:0001104; GO:0006369; GO:0016592; GO:0070847 0 0 0 PF09637; Q9BYE9 CHOYP_CDHR2.2.3 m.12163 sp CDHR2_HUMAN 40 85 49 1 17 99 14 98 2.73E-10 58.5 CDHR2_HUMAN reviewed Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24) CDHR2 PCDH24 PCLKC Homo sapiens (Human) 1310 cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532] GO:0005509; GO:0005903; GO:0007156; GO:0016324; GO:0030054; GO:0030855; GO:0031526; GO:0031528; GO:0032532; GO:0044214; GO:0044331; GO:0050839; GO:0060243; GO:0070062; GO:0090675 0 0 0 PF00028; Q9ESN6 CHOYP_TRIM3.53.58 m.60176 sp TRIM2_MOUSE 24.706 255 169 11 31 270 485 731 2.73E-08 58.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H0J9 CHOYP_PARP12.2.2 m.58090 sp PAR12_HUMAN 25.581 215 145 6 46 253 10 216 2.73E-16 81.6 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9H8W5 CHOYP_LOC100077534.1.1 m.23888 sp TRI45_HUMAN 22.372 371 242 13 16 367 135 478 2.73E-09 63.5 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9R0M5 CHOYP_LOC100371654.1.1 m.14188 sp TPK1_MOUSE 47.521 242 120 3 8 247 7 243 2.73E-76 234 TPK1_MOUSE reviewed Thiamin pyrophosphokinase 1 (mTPK1) (EC 2.7.6.2) (Thiamine pyrophosphokinase 1) Tpk1 Mus musculus (Mouse) 243 thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772] GO:0004788; GO:0005524; GO:0006772; GO:0009229; GO:0016301; GO:0030975 PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1. 0 cd07995; PF04265;PF04263; A0A1F4 CHOYP_BRAFLDRAFT_64392.2.2 m.29142 sp EYS_DROME 46.154 78 41 1 262 338 299 376 2.74E-14 81.3 EYS_DROME reviewed Protein eyes shut (Protein spacemaker) eys spam CG33955 Drosophila melanogaster (Fruit fly) 2176 cell morphogenesis [GO:0000902]; rhabdomere development [GO:0042052]; temperature compensation of the circadian clock [GO:0010378] GO:0000902; GO:0005201; GO:0005509; GO:0005576; GO:0005615; GO:0009986; GO:0010378; GO:0016021; GO:0031513; GO:0042052 0 0 0 PF00008;PF02210; A1A5V9 CHOYP_LOC587346.1.1 m.17791 sp ELP5_DANRE 30.717 293 195 4 2 291 1 288 2.74E-35 132 ELP5_DANRE reviewed Elongator complex protein 5 (Dermal papilla-derived protein 6 homolog) (Retinoic acid-induced protein 12) elp5 derp6 Rai12 zgc:158278 zgc:158285 Danio rerio (Zebrafish) (Brachydanio rerio) 296 "positive regulation of cell migration [GO:0030335]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0030335; GO:0033588 0 0 0 PF10483; A2BD94 CHOYP_LOC581164.1.1 m.44096 sp FB31B_XENLA 30.408 319 184 7 15 326 62 349 2.74E-37 144 FB31B_XENLA reviewed F-box only protein 31-B fbxo31-b Xenopus laevis (African clawed frog) 523 cellular response to DNA damage stimulus [GO:0006974]; mitotic G1 DNA damage checkpoint [GO:0031571]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0006974; GO:0008054; GO:0016567; GO:0019005; GO:0031146; GO:0031571 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; A5D6V4 CHOYP_BRAFLDRAFT_90803.1.1 m.22272 sp TM17B_DANRE 48.634 183 92 2 25 205 7 189 2.74E-55 177 TM17B_DANRE reviewed Transmembrane protein 17B Tmem17b zgc:163141 Danio rerio (Zebrafish) (Brachydanio rerio) 191 cilium assembly [GO:0042384]; smoothened signaling pathway [GO:0007224] GO:0007224; GO:0016021; GO:0035869; GO:0036038; GO:0042384; GO:0060170 0 0 0 PF09799; A8MU46 CHOYP_CG34417.2.2 m.28251 sp SMTL1_HUMAN 55.705 149 60 2 1654 1800 302 446 2.74E-48 183 SMTL1_HUMAN reviewed Smoothelin-like protein 1 SMTNL1 Homo sapiens (Human) 457 negative regulation of vasodilation [GO:0045908]; positive regulation of vasoconstriction [GO:0045907] GO:0005634; GO:0005737; GO:0031430; GO:0031674; GO:0043292; GO:0045907; GO:0045908 0 0 0 PF00307; B0FXQ5 CHOYP_LOC100376720.1.1 m.47672 sp WDY_DROAN 24.977 1105 644 34 67 1144 35 981 2.74E-77 281 WDY_DROAN reviewed WD repeat-containing protein on Y chromosome (WD40 Y) WDY Drosophila ananassae (Fruit fly) 1064 0 0 0 0 0 PF00400; B3EWZ5 CHOYP_NEMVEDRAFT_V1G198667.4.15 m.15415 sp MLRP1_ACRMI 32.692 780 414 30 12 745 760 1474 2.74E-93 323 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E9Q4Z2 CHOYP_ACACA.2.7 m.26843 sp ACACB_MOUSE 66.58 386 112 6 5 381 148 525 2.74E-167 520 ACACB_MOUSE reviewed Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)] Acacb Acc2 Accb Mus musculus (Mouse) 2448 acetyl-CoA metabolic process [GO:0006084]; energy homeostasis [GO:0097009]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; negative regulation of catalytic activity [GO:0043086]; negative regulation of fatty acid beta-oxidation [GO:0031999]; negative regulation of fatty acid oxidation [GO:0046322]; negative regulation of gene expression [GO:0010629]; negative regulation of lipid catabolic process [GO:0050995]; positive regulation of heart growth [GO:0060421]; positive regulation of lipid storage [GO:0010884]; protein homotetramerization [GO:0051289]; regulation of glucose metabolic process [GO:0010906]; response to nutrient levels [GO:0031667] GO:0003989; GO:0004075; GO:0005524; GO:0005634; GO:0005739; GO:0006084; GO:0006633; GO:0010629; GO:0010884; GO:0010906; GO:0012505; GO:0016020; GO:0031667; GO:0031999; GO:0043086; GO:0046322; GO:0046872; GO:0050995; GO:0051289; GO:0060421; GO:0097009; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; O00370 CHOYP_LOC100892427.2.2 m.35357 sp LORF2_HUMAN 29.508 122 86 0 6 127 7 128 2.74E-13 68.9 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O00468 CHOYP_CGD4_750.1.1 m.29180 sp AGRIN_HUMAN 27.941 136 85 4 40 169 629 757 2.74E-06 49.7 AGRIN_HUMAN reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Homo sapiens (Human) 2067 clustering of voltage-gated sodium channels [GO:0045162]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0001523; GO:0002162; GO:0005200; GO:0005509; GO:0005576; GO:0005605; GO:0005737; GO:0005796; GO:0005886; GO:0006024; GO:0006027; GO:0007165; GO:0007213; GO:0016021; GO:0030054; GO:0030198; GO:0030203; GO:0031012; GO:0033691; GO:0035374; GO:0043113; GO:0043202; GO:0043236; GO:0043395; GO:0043547; GO:0045162; GO:0045202; GO:0045887; GO:0045944; GO:0050808; GO:0051491; GO:0070062 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF03146;PF01390; O46581 CHOYP_DMOJ_GI15072.1.1 m.5418 sp COX41_THEGE 32.374 139 83 4 73 205 10 143 2.74E-18 81.3 COX41_THEGE reviewed "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) (Fragment)" COX4I1 COX4 Theropithecus gelada (Gelada baboon) 144 0 GO:0004129; GO:0005743 0 0 cd00922; PF02936; O61231 CHOYP_RL10.3.3 m.56946 sp RL10_DROME 75.781 128 31 0 1 128 87 214 2.74E-69 210 RL10_DROME reviewed 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0043025; GO:0051297; GO:0051298 0 0 cd01433; PF00252; O70165 CHOYP_BRAFLDRAFT_86061.10.13 m.52540 sp FCN1_MOUSE 43.946 223 115 5 35 252 115 332 2.74E-52 176 FCN1_MOUSE reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Mus musculus (Mouse) 334 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 secretion [GO:2000484]" GO:0001867; GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0046872; GO:0097367; GO:2000484 0 0 0 PF01391;PF00147; O75179 CHOYP_LOC587475.3.3 m.60916 sp ANR17_HUMAN 32.321 560 328 18 14 557 193 717 2.74E-57 211 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O96133 CHOYP_BRAFLDRAFT_120966.1.3 m.28058 sp YB145_PLAF7 29.762 84 59 0 38 121 1285 1368 2.74E-07 55.8 YB145_PLAF7 reviewed Uncharacterized protein PFB0145c PFB0145c Plasmodium falciparum (isolate 3D7) 1979 0 GO:0005737; GO:0016020 0 0 0 0 P10394 CHOYP_contig_032808 m.37483 sp POL4_DROME 31.652 932 562 17 260 1133 276 1190 2.74E-134 443 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P10994 CHOYP_CYI.1.1 m.57969 sp ACTS_PLEWA 76.238 101 16 1 1 101 33 125 2.74E-53 165 ACTS_PLEWA reviewed "Actin, alpha skeletal muscle (Fragment)" 0 Pleurodeles waltl (Iberian ribbed newt) 125 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P14133 CHOYP_LOC584333.1.1 m.42540 sp ASO_CUCSA 39.773 176 79 7 88 251 53 213 2.74E-29 127 ASO_CUCSA reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) 0 Cucumis sativus (Cucumber) 587 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P17644 CHOYP_LOC577316.1.1 m.48711 sp ACH2_DROME 34.16 363 224 5 36 388 41 398 2.74E-68 232 ACH2_DROME reviewed Acetylcholine receptor subunit alpha-like 2 (Nicotinic acetylcholine receptor alpha 2) nAChRalpha2 Acr96Ab AcrE nAcRalpha-96Ab sad CG6844 Drosophila melanogaster (Fruit fly) 576 "cation transport [GO:0006812]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0006812; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211 0 0 0 PF02931;PF02932; P41737 CHOYP_LRCH3.4.4 m.63279 sp LRCH1_FELCA 59.677 124 50 0 318 441 122 245 2.74E-45 160 LRCH1_FELCA reviewed Leucine-rich repeat and calponin homology domain-containing protein 1 (Neuronal protein) (Fragment) 0 Felis catus (Cat) (Felis silvestris catus) 251 0 0 0 0 0 PF00307; P46530 CHOYP_NOTCH.2.6 m.3877 sp NOTC1_DANRE 35.714 154 84 6 663 814 566 706 2.74E-11 72.4 NOTC1_DANRE reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1a notch Danio rerio (Zebrafish) (Brachydanio rerio) 2437 "angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; dorsal aorta development [GO:0035907]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; habenula development [GO:0021986]; hematopoietic progenitor cell differentiation [GO:0002244]; hypochord development [GO:0055016]; negative regulation of neurogenesis [GO:0050768]; neural plate development [GO:0001840]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; pancreas development [GO:0031016]; peripheral nervous system neuron axonogenesis [GO:0048936]; positive regulation of mesodermal cell fate specification [GO:0048337]; regulation of endodermal cell fate specification [GO:0042663]; regulation of receptor-mediated endocytosis [GO:0048259]; regulation of transcription, DNA-templated [GO:0006355]; somatic motor neuron differentiation [GO:0021523]; somitogenesis [GO:0001756]; spinal cord radial glial cell differentiation [GO:0021531]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron differentiation [GO:0021514]" GO:0001525; GO:0001756; GO:0001840; GO:0002244; GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0007219; GO:0007368; GO:0009952; GO:0016021; GO:0021514; GO:0021523; GO:0021531; GO:0021986; GO:0031016; GO:0031017; GO:0035907; GO:0042663; GO:0048259; GO:0048337; GO:0048699; GO:0048936; GO:0050768; GO:0055016; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P82596 CHOYP_NEMVEDRAFT_V1G196785.1.1 m.30084 sp PLC_HALLA 40.909 132 72 3 21 151 2 128 2.74E-25 97.8 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q0VCN3 CHOYP_LOC100376429.1.1 m.24844 sp IFT27_BOVIN 54.396 182 83 0 5 186 4 185 2.74E-73 222 IFT27_BOVIN reviewed Intraflagellar transport protein 27 homolog (IFT27) (Putative GTP-binding protein RAY-like) (Rab-like protein 4) IFT27 RABL4 RAYL Bos taurus (Bovine) 186 intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]; small GTPase mediated signal transduction [GO:0007264]; smoothened signaling pathway [GO:0007224] GO:0005525; GO:0005622; GO:0005929; GO:0006886; GO:0007224; GO:0007264; GO:0030992; GO:0042073 0 0 0 PF00071; Q11002 CHOYP_PHUM_PHUM216240.1.1 m.9796 sp CANA_DROME 41.752 491 263 8 73 553 76 553 2.74E-127 395 CANA_DROME reviewed Calpain-A (EC 3.4.22.-) (Calcium-activated neutral proteinase A) (CANP A) [Cleaved into: Calpain-A catalytic subunit] CalpA CG7563 Drosophila melanogaster (Fruit fly) 828 BMP signaling pathway involved in spinal cord dorsal/ventral patterning [GO:0021919]; cuticle development [GO:0042335]; defense response to fungus [GO:0050832]; determination of adult lifespan [GO:0008340]; dorsal/ventral pattern formation [GO:0009953]; phagocytosis [GO:0006909]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508] GO:0004198; GO:0005509; GO:0005622; GO:0005737; GO:0006508; GO:0006909; GO:0008340; GO:0009953; GO:0015629; GO:0016540; GO:0021919; GO:0042335; GO:0043025; GO:0050832 0 0 0 PF01067;PF00648; Q28864 CHOYP_LOC100905729.3.3 m.58833 sp TFPI1_MACMU 37.838 74 46 0 32 105 39 112 2.74E-13 68.9 TFPI1_MACMU reviewed Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI TFPI1 Macaca mulatta (Rhesus macaque) 304 blood coagulation [GO:0007596] GO:0004867; GO:0005615; GO:0007596; GO:0009986 0 0 0 PF00014; Q29RP8 CHOYP_LOC663776.1.1 m.66113 sp KMT5B_BOVIN 52.812 320 109 7 23 312 55 362 2.74E-104 330 KMT5B_BOVIN reviewed Histone-lysine N-methyltransferase KMT5B (EC 2.1.1.43) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) KMT5B SUV420H1 Bos taurus (Bovine) 393 "histone H4-K20 trimethylation [GO:0034773]; muscle organ development [GO:0007517]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007517; GO:0018024; GO:0034773; GO:0042799 0 0 0 PF00856; Q2QUN2 CHOYP_LOC100206475.5.16 m.29989 sp LAC24_ORYSJ 27.474 586 311 18 96 637 42 557 2.74E-57 208 LAC24_ORYSJ reviewed Laccase-24 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 24) (Diphenol oxidase 24) (Urishiol oxidase 24) LAC24 Os12g0258700 LOC_Os12g15680 OsJ_016843 OsJ_17624 Oryza sativa subsp. japonica (Rice) 579 lignin catabolic process [GO:0046274] GO:0005507; GO:0016722; GO:0046274; GO:0048046; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q3UDP0 CHOYP_NEMVEDRAFT_V1G242282.1.1 m.59797 sp WDR41_MOUSE 28.696 460 277 16 12 441 11 449 2.74E-47 172 WDR41_MOUSE reviewed WD repeat-containing protein 41 Wdr41 Mus musculus (Mouse) 460 0 GO:0005765 0 0 0 PF00400; Q3UI66 CHOYP_LOC100494757.1.1 m.63649 sp CCD34_MOUSE 33.562 292 163 8 29 317 58 321 2.74E-24 105 CCD34_MOUSE reviewed Coiled-coil domain-containing protein 34 Ccdc34 Mus musculus (Mouse) 367 0 0 0 0 0 0 Q3UVD5 CHOYP_SOX2.2.2 m.61088 sp LGR6_MOUSE 28.329 413 223 11 4 379 8 384 2.74E-29 126 LGR6_MOUSE reviewed Leucine-rich repeat-containing G-protein coupled receptor 6 Lgr6 Mus musculus (Mouse) 967 positive regulation of cell migration [GO:0030335]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt signaling pathway [GO:0016055] GO:0005886; GO:0016021; GO:0016055; GO:0016500; GO:0030177; GO:0030335; GO:0031982 0 0 0 PF13855; Q460N5 CHOYP_PARP14.12.22 m.48511 sp PAR14_HUMAN 29.362 235 142 5 133 358 1029 1248 2.74E-18 94.7 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q54TD8 CHOYP_WDR5.3.3 m.23236 sp BOP1_DICDI 30.488 82 57 0 31 112 478 559 2.74E-08 53.9 BOP1_DICDI reviewed Ribosome biogenesis protein BOP1 homolog DDB_G0281839 Dictyostelium discoideum (Slime mold) 833 "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]" GO:0000463; GO:0000466; GO:0005654; GO:0005730; GO:0006364; GO:0030687; GO:0042273; GO:0043021; GO:0070545 0 0 0 PF08145;PF00400; Q5F478 CHOYP_CDC23.1.1 m.6464 sp ANR44_CHICK 29.717 212 125 4 32 242 243 431 2.74E-20 95.5 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5F478 CHOYP_TSP_04318.1.1 m.55742 sp ANR44_CHICK 29.717 212 125 4 32 242 243 431 2.74E-20 95.5 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5R1S9 CHOYP_CAF1B.2.4 m.38999 sp CAF1B_CHICK 57.616 151 61 2 1 148 1 151 2.74E-54 182 CAF1B_CHICK reviewed Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) CHAF1B CAF1P60 RCJMB04_5h12 Gallus gallus (Chicken) 566 "cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006260; GO:0006281; GO:0006334; GO:0006351; GO:0006355; GO:0007049; GO:0031497; GO:0033186; GO:0042393 0 0 0 PF15512;PF00400; Q5R1S9 CHOYP_CAF1B.3.4 m.40993 sp CAF1B_CHICK 57.616 151 61 2 1 148 1 151 2.74E-54 182 CAF1B_CHICK reviewed Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) CHAF1B CAF1P60 RCJMB04_5h12 Gallus gallus (Chicken) 566 "cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006260; GO:0006281; GO:0006334; GO:0006351; GO:0006355; GO:0007049; GO:0031497; GO:0033186; GO:0042393 0 0 0 PF15512;PF00400; Q5R4C3 CHOYP_TM50B.1.1 m.25659 sp TM50B_PONAB 67.296 159 49 2 1 158 1 157 2.74E-74 222 TM50B_PONAB reviewed Transmembrane protein 50B TMEM50B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 158 0 GO:0016021 0 0 0 PF05255; Q5REB1 CHOYP_MPPD2.3.3 m.44182 sp MPPD2_PONAB 55.981 209 90 2 1 208 85 292 2.74E-77 237 MPPD2_PONAB reviewed Metallophosphoesterase MPPED2 (EC 3.1.-.-) (Metallophosphoesterase domain-containing protein 2) MPPED2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 294 0 GO:0016787; GO:0046872 0 0 0 PF00149; Q5TAA0 CHOYP_BRAFLDRAFT_68270.2.6 m.23511 sp TTC22_HUMAN 26.933 375 220 19 5 352 143 490 2.74E-06 53.9 TTC22_HUMAN reviewed Tetratricopeptide repeat protein 22 (TPR repeat protein 22) TTC22 Homo sapiens (Human) 569 0 0 0 0 0 0 Q68Y56 CHOYP_TLR22.3.3 m.60735 sp TLR4_PIG 24.142 787 502 33 3 747 31 764 2.74E-19 96.7 TLR4_PIG reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Sus scrofa (Pig) 841 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0001530; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005887; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13855;PF01582; Q6A065 CHOYP_contig_024154 m.27435 sp CE170_MOUSE 29.752 121 76 2 996 1111 1381 1497 2.74E-06 55.8 CE170_MOUSE reviewed Centrosomal protein of 170 kDa (Cep170) Cep170 Kiaa0470 Mus musculus (Mouse) 1588 0 GO:0005737; GO:0005813; GO:0005814; GO:0005819; GO:0005874; GO:0031965 0 0 0 PF15308;PF00498; Q6DJ08 CHOYP_S2538.2.2 m.22854 sp S2538_XENTR 51.111 135 65 1 7 140 86 220 2.74E-39 137 S2538_XENTR reviewed Solute carrier family 25 member 38 slc25a38 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 302 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; translation [GO:0006412] GO:0003735; GO:0005215; GO:0005743; GO:0006412; GO:0006783; GO:0016021; GO:0030218 0 0 0 PF00153; Q7JQD3 CHOYP_LOC100533528.2.2 m.26125 sp GELS1_LUMTE 54.595 370 158 5 19 385 5 367 2.74E-135 394 GELS1_LUMTE reviewed Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) 367 actin filament capping [GO:0051693]; actin filament fragmentation [GO:0030043]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; multicellular organism development [GO:0007275] GO:0003779; GO:0005509; GO:0005737; GO:0005856; GO:0007275; GO:0030041; GO:0030043; GO:0045010; GO:0051014; GO:0051693 0 0 0 PF00626; Q7Z408 CHOYP_SVEP1.4.8 m.31599 sp CSMD2_HUMAN 34.483 116 66 4 182 291 2841 2952 2.74E-11 69.3 CSMD2_HUMAN reviewed CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2) CSMD2 KIAA1884 Homo sapiens (Human) 3487 0 GO:0005886; GO:0016021 0 0 0 PF00431;PF00084; Q80V70 CHOYP_MEG10.23.91 m.32366 sp MEGF6_MOUSE 27.672 524 299 16 7 514 675 1134 2.74E-38 153 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q865F1 CHOYP_BRAFLDRAFT_123736.1.1 m.48671 sp MTP_PIG 27.039 895 599 19 13 870 1 878 2.74E-107 354 MTP_PIG reviewed Microsomal triglyceride transfer protein large subunit MTTP MTP Sus scrofa (Pig) 894 phospholipid transport [GO:0015914]; plasma lipoprotein particle assembly [GO:0034377]; triglyceride transport [GO:0034197] GO:0005548; GO:0005783; GO:0008289; GO:0015914; GO:0034197; GO:0034377; GO:0046982 0 0 0 PF01347; Q8K337 CHOYP_LOC101170302.1.1 m.22185 sp I5P2_MOUSE 41.27 693 370 11 287 965 323 992 2.74E-163 508 I5P2_MOUSE reviewed "Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (Inositol polyphosphate-5-phosphatase B) (Phosphoinositide 5-phosphatase) (5PTase)" Inpp5b Mus musculus (Mouse) 993 in utero embryonic development [GO:0001701]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of protein processing [GO:0070613]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; sperm motility [GO:0030317] GO:0001701; GO:0004439; GO:0004445; GO:0005737; GO:0005793; GO:0005829; GO:0007165; GO:0007283; GO:0016020; GO:0016021; GO:0030317; GO:0030670; GO:0031901; GO:0046856; GO:0046872; GO:0052658; GO:0070613 0 0 0 PF03372;PF16776;PF00620; Q8R2K1 CHOYP_LOC100377200.1.2 m.19811 sp FUCM_MOUSE 50 144 48 2 3 123 4 146 2.74E-41 137 FUCM_MOUSE reviewed Fucose mutarotase (EC 5.1.3.29) Fuom Le51 Mus musculus (Mouse) 153 female mating behavior [GO:0060180]; fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]; negative regulation of neuron differentiation [GO:0045665] GO:0006004; GO:0016857; GO:0036065; GO:0042806; GO:0045665; GO:0060180 0 0 0 PF05025; Q92193 CHOYP_ACT2.2.3 m.14618 sp ACT_CRAVI 76.316 114 4 1 1 114 107 197 2.74E-52 168 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96NG3 CHOYP_LOC100179722.1.1 m.20320 sp TTC25_HUMAN 36.726 226 143 0 283 508 273 498 2.74E-39 155 TTC25_HUMAN reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) TTC25 Homo sapiens (Human) 672 0 GO:0005737 0 0 0 PF13181; Q9BRZ2 CHOYP_NEMVEDRAFT_V1G217091.4.4 m.60357 sp TRI56_HUMAN 25.185 270 174 11 6 262 9 263 2.74E-14 79 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9DBX3 CHOYP_SUSD2.1.1 m.66035 sp SUSD2_MOUSE 31.729 665 390 25 8 642 182 812 2.74E-82 280 SUSD2_MOUSE reviewed Sushi domain-containing protein 2 Susd2 Mus musculus (Mouse) 820 immune response [GO:0006955]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782] GO:0005044; GO:0005886; GO:0006955; GO:0016021; GO:0030247; GO:0051782; GO:0070062; GO:1902807 0 0 0 PF03782;PF01033;PF00084;PF00094; Q9UGM3 CHOYP_TRIADDRAFT_52608.1.2 m.25467 sp DMBT1_HUMAN 45.327 214 104 6 2022 2227 494 702 2.74E-43 179 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9USQ7 CHOYP_LOC100744165.1.1 m.7204 sp DPH6_SCHPO 40.07 569 298 17 1 558 1 537 2.74E-119 372 DPH6_SCHPO reviewed Diphthine--ammonia ligase (EC 6.3.1.14) (Diphthamide synthase) (Diphthamide synthetase) mug71 SPBC577.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 606 meiotic cell cycle [GO:0051321]; peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183] GO:0005524; GO:0005634; GO:0005829; GO:0017178; GO:0017183; GO:0051321 PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. 0 cd01994; PF01902;PF01042; Q9VEU1 CHOYP_CAD89.1.1 m.14552 sp CAD89_DROME 27.576 330 200 13 12 315 25 341 2.74E-14 80.1 CAD89_DROME reviewed Cadherin-89D Cad89D CG14900 Drosophila melanogaster (Fruit fly) 2240 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005887; GO:0007156; GO:0016339; GO:0044331 0 0 0 PF00028; Q9VXY2 CHOYP_LOC663968.1.1 m.38633 sp MADD_DROME 54.248 153 68 2 151 303 1147 1297 2.74E-49 182 MADD_DROME reviewed MAP kinase-activating death domain protein (Rab3 guanyl-nucleotide exchange factor) Rab3-GEF CG5627 Drosophila melanogaster (Fruit fly) 2084 activation of MAPK activity [GO:0000187]; apoptotic process [GO:0006915]; neurotransmitter secretion [GO:0007269]; regulation of cell cycle [GO:0051726]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Rab protein signal transduction [GO:0032483]; vesicle-mediated transport [GO:0016192] GO:0000187; GO:0006915; GO:0007269; GO:0008021; GO:0016021; GO:0016192; GO:0017112; GO:0032483; GO:0051726; GO:1902041 0 0 0 PF02141;PF03456; A4IF63 CHOYP_BRAFLDRAFT_87270.2.2 m.60879 sp TRIM2_BOVIN 26.57 207 143 7 214 414 540 743 2.75E-09 62.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7SLZ2 CHOYP_STING.1.3 m.47789 sp STING_NEMVE 28.289 152 99 5 156 301 175 322 2.75E-08 58.5 STING_NEMVE reviewed Stimulator of interferon genes protein (STING) v1g246111 Nematostella vectensis (Starlet sea anemone) 377 activation of innate immune response [GO:0002218]; positive regulation of type I interferon production [GO:0032481] GO:0002218; GO:0005789; GO:0016021; GO:0032481; GO:0035438; GO:0061507 0 0 0 PF15009; B0BNE5 CHOYP_BRAFLDRAFT_79044.2.2 m.62650 sp ESTD_RAT 73.214 280 75 0 42 321 1 280 2.75E-161 454 ESTD_RAT reviewed S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) Esd Rattus norvegicus (Rat) 282 formaldehyde catabolic process [GO:0046294] GO:0016023; GO:0018738; GO:0046294; GO:0052689 0 0 0 PF00756; B3EWZ5 CHOYP_LOC100120262.2.2 m.27535 sp MLRP1_ACRMI 40.994 161 91 3 379 537 1648 1806 2.75E-30 130 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; C9JTQ0 CHOYP_CBWD1.1.1 m.6824 sp ANR63_HUMAN 35.032 157 99 3 49 203 18 173 2.75E-20 95.1 ANR63_HUMAN reviewed Ankyrin repeat domain-containing protein 63 ANKRD63 Homo sapiens (Human) 380 0 0 0 0 0 PF12796; G5EFM9 CHOYP_LOC100893147.1.1 m.48000 sp NEKL3_CAEEL 27.225 191 131 5 115 298 88 277 2.75E-11 66.6 NEKL3_CAEEL reviewed Serine/threonine-protein kinase nekl-3 (EC 2.7.11.1) (Molting protein MLT-1) (Never in mitosis A kinase-like 3) (NimA kinase-like 3) nekl-3 mlt-1 F19H6.1 Caenorhabditis elegans 302 gonad development [GO:0008406]; molting cycle [GO:0042303]; multicellular organism growth [GO:0035264] GO:0004674; GO:0005524; GO:0005737; GO:0008406; GO:0016324; GO:0035264; GO:0042303; GO:0046872 0 0 0 PF00069; O00748 CHOYP_LOC100770313.1.1 m.3513 sp EST2_HUMAN 32.082 586 334 18 16 580 12 554 2.75E-83 273 EST2_HUMAN reviewed Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) CES2 ICE Homo sapiens (Human) 559 catabolic process [GO:0009056]; xenobiotic metabolic process [GO:0006805] GO:0005615; GO:0005783; GO:0005788; GO:0006805; GO:0009056; GO:0047374; GO:0052689 0 0 0 PF00135; P02595 CHOYP_CALM.48.50 m.59909 sp CALM_PATSP 35 140 88 2 97 234 8 146 2.75E-17 79 CALM_PATSP reviewed Calmodulin (CaM) 0 Patinopecten sp. (Scallop) 149 0 GO:0005509 0 0 0 PF13499; P0C0T0 CHOYP_LITAF.1.1 m.10983 sp LITAF_RAT 42.609 115 51 3 21 131 58 161 2.75E-23 91.7 LITAF_RAT reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Estrogen-enhanced transcript protein 1) (Eet-1) Litaf Rattus norvegicus (Rat) 161 "aging [GO:0007568]; apoptotic process [GO:0006915]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of cytokine production [GO:0001817]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001817; GO:0004871; GO:0005576; GO:0005654; GO:0005765; GO:0005794; GO:0005886; GO:0006351; GO:0006355; GO:0006915; GO:0007568; GO:0042347; GO:0043123; GO:0050699; GO:0071222 0 0 0 PF10601; P28827 CHOYP_PTPRM.1.15 m.2929 sp PTPRM_HUMAN 34.694 735 436 14 505 1203 723 1449 2.75E-123 418 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P41436 CHOYP_BIRC3.7.7 m.66659 sp IAP_GVCPM 45.238 84 44 2 74 157 102 183 2.75E-17 79.3 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P41824 CHOYP_YBOXH.3.4 m.18818 sp YBOXH_APLCA 68.75 80 15 1 1 80 52 121 2.75E-30 110 YBOXH_APLCA reviewed Y-box factor homolog (APY1) 0 Aplysia californica (California sea hare) 253 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355 0 0 cd04458; PF00313; P78524 CHOYP_ST5.1.1 m.54184 sp ST5_HUMAN 35.849 477 272 6 557 1008 666 1133 2.75E-89 313 ST5_HUMAN reviewed Suppression of tumorigenicity 5 protein (DENN domain-containing protein 2B) (HeLa tumor suppression 1) ST5 DENND2B HTS1 Homo sapiens (Human) 1137 positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0017112; GO:0070374 0 0 0 PF03455;PF02141;PF03456; Q07343 CHOYP_PDE4D.1.1 m.50857 sp PDE4B_HUMAN 57.565 271 107 4 52 320 159 423 2.75E-100 313 PDE4B_HUMAN reviewed "cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32)" PDE4B DPDE4 Homo sapiens (Human) 736 cAMP catabolic process [GO:0006198]; cellular response to drug [GO:0035690]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to lipopolysaccharide [GO:0071222]; leukocyte migration [GO:0050900]; negative regulation of relaxation of cardiac muscle [GO:1901898]; neutrophil chemotaxis [GO:0030593]; neutrophil homeostasis [GO:0001780]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-2 production [GO:0032743]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of high voltage-gated calcium channel activity [GO:1901841]; T cell receptor signaling pathway [GO:0050852] GO:0000930; GO:0001780; GO:0004115; GO:0005813; GO:0005829; GO:0006198; GO:0008021; GO:0014069; GO:0016020; GO:0030018; GO:0030552; GO:0030593; GO:0032729; GO:0032743; GO:0035690; GO:0043197; GO:0044325; GO:0046872; GO:0050852; GO:0050900; GO:0071222; GO:0071872; GO:0071944; GO:0086004; GO:1901841; GO:1901898 "PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." 0 0 PF00233; Q24246 CHOYP_DIC.1.1 m.37693 sp DYIN_DROME 32.275 189 120 5 3 187 2 186 2.75E-11 65.5 DYIN_DROME reviewed "Cytoplasmic dynein 1 intermediate chain (DH IC) (Dynein intermediate chain, cytosolic) (Protein short wing)" sw Cdic Dic19B CG18000 Drosophila melanogaster (Fruit fly) 663 axo-dendritic transport [GO:0008088]; cellularization [GO:0007349]; centrosome localization [GO:0051642]; eye photoreceptor cell differentiation [GO:0001754]; microtubule-based movement [GO:0007018]; microtubule cytoskeleton organization [GO:0000226]; protein localization to kinetochore [GO:0034501]; sperm individualization [GO:0007291]; spindle organization [GO:0007051] GO:0000226; GO:0001754; GO:0003774; GO:0005765; GO:0005868; GO:0005874; GO:0005875; GO:0007018; GO:0007051; GO:0007291; GO:0007349; GO:0008088; GO:0031965; GO:0034501; GO:0043005; GO:0045503; GO:0045504; GO:0051642; GO:0070840 0 0 0 PF11540; Q2KJC3 CHOYP_MPEG1.2.5 m.18288 sp MPEG1_BOVIN 34.453 685 397 17 49 719 45 691 2.75E-126 395 MPEG1_BOVIN reviewed Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Bos taurus (Bovine) 717 0 GO:0016021 0 0 0 PF01823; Q3T0Q8 CHOYP_UT14A.1.1 m.44047 sp UT14A_BOVIN 44.286 350 185 3 13 354 30 377 2.75E-70 249 UT14A_BOVIN reviewed U3 small nucleolar RNA-associated protein 14 homolog A UTP14A Bos taurus (Bovine) 770 maturation of SSU-rRNA [GO:0030490] GO:0005730; GO:0030490; GO:0032040 0 0 0 PF04615; Q49B93 CHOYP_LOC100313639.2.3 m.22150 sp SC5AC_MOUSE 30.498 482 314 11 4 479 123 589 2.75E-57 203 SC5AC_MOUSE reviewed Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) Slc5a12 Smct2 Mus musculus (Mouse) 619 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015129; GO:0015293; GO:0015355; GO:0016324; GO:0070062 0 0 0 PF00474; Q575S8 CHOYP_PHUM_PHUM323880.4.4 m.48656 sp CYGB2_DANRE 29.054 148 101 3 35 179 19 165 2.75E-18 80.9 CYGB2_DANRE reviewed Cytoglobin-2 cygb2 cygb-2 Danio rerio (Zebrafish) (Brachydanio rerio) 179 0 GO:0005344; GO:0005506; GO:0005737; GO:0019825; GO:0020037; GO:0098809 0 0 0 PF00042; Q5R4J5 CHOYP_LOC100376714.1.3 m.10200 sp SYT1_PONAB 38.745 271 157 4 18 285 141 405 2.75E-66 215 SYT1_PONAB reviewed Synaptotagmin-1 (Synaptotagmin I) (SytI) SYT1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 419 cell differentiation [GO:0030154] GO:0016021; GO:0030054; GO:0030154; GO:0030672; GO:0042584; GO:0046872 0 0 0 PF00168; Q5RE15 CHOYP_LOC100372505.1.2 m.10261 sp PSMD8_PONAB 64.906 265 92 1 2 265 25 289 2.75E-119 345 PSMD8_PONAB reviewed 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (Fragment) PSMD8 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 289 proteolysis [GO:0006508] GO:0005838; GO:0006508; GO:0022624 0 0 0 PF10075; Q5Y4N8 CHOYP_BRAFLDRAFT_88050.1.2 m.21153 sp AGRE1_RAT 36.196 326 157 13 422 709 42 354 2.75E-43 172 AGRE1_RAT reviewed Adhesion G protein-coupled receptor E2 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor) Adgre1 Emr1 Rattus norvegicus (Rat) 932 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] GO:0002250; GO:0004930; GO:0005509; GO:0007166; GO:0009897; GO:0016021 0 0 0 PF00002;PF12662;PF07645;PF01825; Q5ZIJ9 CHOYP_LOC100701493.1.1 m.20768 sp MIB2_CHICK 33.333 336 184 4 1 309 493 815 2.75E-50 187 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q5ZKF6 CHOYP_5NT3B.1.1 m.50865 sp 5NT3B_CHICK 46.914 243 129 0 28 270 1 243 2.75E-79 244 5NT3B_CHICK reviewed 7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase) NT5C3B NT5C3L RCJMB04_11c18 Gallus gallus (Chicken) 289 nucleotide metabolic process [GO:0009117] GO:0000166; GO:0000287; GO:0005737; GO:0008253; GO:0009117 0 0 0 PF05822; Q63931 CHOYP_LOC100204399.1.1 m.53628 sp CCKAR_CAVPO 21.905 420 231 16 25 419 33 380 2.75E-08 59.3 CCKAR_CAVPO reviewed Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Cavia porcellus (Guinea pig) 430 0 GO:0004951; GO:0005886; GO:0016021 0 0 0 PF00001;PF09193; Q67XW5 CHOYP_MYCGRDRAFT_89575.2.12 m.13047 sp UBP18_ARATH 46.774 62 24 2 76 133 52 108 2.75E-06 53.5 UBP18_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (Deubiquitinating enzyme 18) (AtUBP18) (Ubiquitin thioesterase 18) (Ubiquitin-specific-processing protease 18) UBP18 At4g31670 F28M20.140 Arabidopsis thaliana (Mouse-ear cress) 631 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016021; GO:0016579; GO:0036459; GO:0046872 0 0 0 PF00443;PF01753; Q6QD59 CHOYP_LOC100374003.2.2 m.17718 sp SEC20_MOUSE 46.429 224 119 1 2 225 3 225 2.75E-52 171 SEC20_MOUSE reviewed Vesicle transport protein SEC20 Bnip1 Sec20 Sec20l Mus musculus (Mouse) 228 apoptotic process [GO:0006915]; autophagy [GO:0006914]; endoplasmic reticulum membrane fusion [GO:0016320]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0005484; GO:0005635; GO:0005737; GO:0005739; GO:0005783; GO:0005789; GO:0006914; GO:0006915; GO:0007029; GO:0015031; GO:0016021; GO:0016192; GO:0016320; GO:0031201; GO:0043231 0 0 0 PF03908; Q6RUV5 CHOYP_RAC1.3.3 m.57018 sp RAC1_RAT 89.583 192 19 1 15 205 1 192 2.75E-128 362 RAC1_RAT reviewed Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) 192 "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure arrangement [GO:0048532]; auditory receptor cell morphogenesis [GO:0002093]; axon guidance [GO:0007411]; bone resorption [GO:0045453]; cell-cell junction organization [GO:0045216]; cell motility [GO:0048870]; cell proliferation [GO:0008283]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex GABAergic interneuron development [GO:0021894]; cerebral cortex radially oriented cell migration [GO:0021799]; chemotaxis [GO:0006935]; cochlea morphogenesis [GO:0090103]; dendrite morphogenesis [GO:0048813]; dopaminergic neuron differentiation [GO:0071542]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; engulfment of apoptotic cell [GO:0043652]; epithelial cell morphogenesis [GO:0003382]; G-protein coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; hyperosmotic response [GO:0006972]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; mast cell chemotaxis [GO:0002551]; negative regulation of interleukin-23 production [GO:0032707]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of DNA replication [GO:0045740]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane [GO:0072659]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; regulation of cell size [GO:0008361]; regulation of fibroblast migration [GO:0010762]; regulation of neuron maturation [GO:0014041]; regulation of respiratory burst [GO:0060263]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000139; GO:0001891; GO:0001934; GO:0002093; GO:0002551; GO:0003382; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005802; GO:0005829; GO:0005884; GO:0005925; GO:0006935; GO:0006972; GO:0007015; GO:0007186; GO:0007411; GO:0008283; GO:0008361; GO:0010592; GO:0010762; GO:0014041; GO:0016020; GO:0016601; GO:0017137; GO:0019897; GO:0019901; GO:0021799; GO:0021831; GO:0021894; GO:0030027; GO:0030032; GO:0030036; GO:0030041; GO:0030334; GO:0030838; GO:0031410; GO:0031901; GO:0032587; GO:0032707; GO:0034446; GO:0036464; GO:0042470; GO:0042826; GO:0043552; GO:0043652; GO:0045216; GO:0045453; GO:0045740; GO:0048532; GO:0048813; GO:0048870; GO:0048873; GO:0051022; GO:0051496; GO:0051668; GO:0051894; GO:0051932; GO:0060071; GO:0060263; GO:0070062; GO:0071260; GO:0071526; GO:0071542; GO:0072659; GO:0090023; GO:0090103; GO:0097178; GO:1900026 0 0 0 PF00071; Q80VI1 CHOYP_LOC100373444.37.79 m.33884 sp TRI56_MOUSE 42.373 59 26 1 12 70 17 67 2.75E-09 56.6 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q8NFD2 CHOYP_TVAG_388180.5.8 m.32974 sp ANKK1_HUMAN 37.607 117 57 1 46 162 394 494 2.75E-16 78.6 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8TDB6 CHOYP_LOC100060632.3.3 m.64890 sp DTX3L_HUMAN 48.416 221 104 5 606 819 522 739 2.75E-57 213 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q91312 CHOYP_LOC658864.1.1 m.50920 sp CRYAB_LITCT 31.875 160 98 5 44 194 8 165 2.75E-17 78.6 CRYAB_LITCT reviewed Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 173 0 GO:0005212; GO:0042803; GO:0046872 0 0 0 PF00525;PF00011; Q9BX68 CHOYP_LOC100691034.2.2 m.21641 sp HINT2_HUMAN 68.504 127 39 1 65 190 37 163 2.75E-59 185 HINT2_HUMAN reviewed "Histidine triad nucleotide-binding protein 2, mitochondrial (HINT-2) (EC 3.-.-.-) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein)" HINT2 Homo sapiens (Human) 163 apoptotic process [GO:0006915]; steroid biosynthetic process [GO:0006694] GO:0000166; GO:0005730; GO:0005739; GO:0006694; GO:0006915; GO:0016787 0 0 0 PF01230; Q9NJV4 CHOYP_LOAG_05095.1.2 m.42565 sp ACT1_NAEPR 29.101 378 241 9 1874 2239 3 365 2.75E-45 172 ACT1_NAEPR reviewed Actin-1 ACT1 Naegleria pringsheimi (Amoeba) 374 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9NQM4 CHOYP_LOC756974.1.1 m.16884 sp PIHD3_HUMAN 41.622 185 104 3 8 191 32 213 2.75E-43 146 PIHD3_HUMAN reviewed Protein PIH1D3 (PIH1 domain-containing protein 3) (Sarcoma antigen NY-SAR-97) PIH1D3 CXorf41 Homo sapiens (Human) 214 axonemal dynein complex assembly [GO:0070286]; sperm motility [GO:0030317] GO:0005737; GO:0030317; GO:0051087; GO:0070286 0 0 0 0 Q9QUN7 CHOYP_LOC491698.1.1 m.58609 sp TLR2_MOUSE 39.806 103 56 4 14 112 641 741 2.75E-10 65.1 TLR2_MOUSE reviewed Toll-like receptor 2 (CD antigen CD282) Tlr2 Mus musculus (Mouse) 784 cell surface pattern recognition receptor signaling pathway [GO:0002752]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to peptidoglycan [GO:0071224]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; chloramphenicol transport [GO:0042892]; cytokine secretion involved in immune response [GO:0002374]; defense response to Gram-positive bacterium [GO:0050830]; detection of diacyl bacterial lipopeptide [GO:0042496]; detection of triacyl bacterial lipopeptide [GO:0042495]; I-kappaB phosphorylation [GO:0007252]; induction by symbiont of defense-related host nitric oxide production [GO:0052063]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-10 production [GO:0032613]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-17 production [GO:0032700]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of xenophagy [GO:1904417]; regulation of dendritic cell cytokine production [GO:0002730]; response to bacterium [GO:0009617]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; toll-like receptor 2 signaling pathway [GO:0034134] GO:0001530; GO:0002238; GO:0002374; GO:0002687; GO:0002730; GO:0002752; GO:0002755; GO:0004872; GO:0004888; GO:0005737; GO:0005794; GO:0005886; GO:0006954; GO:0007252; GO:0008329; GO:0009617; GO:0009897; GO:0009986; GO:0010628; GO:0016021; GO:0030177; GO:0030670; GO:0031226; GO:0032494; GO:0032613; GO:0032695; GO:0032700; GO:0032722; GO:0032728; GO:0032735; GO:0032741; GO:0032755; GO:0032757; GO:0032760; GO:0034123; GO:0034134; GO:0035325; GO:0035354; GO:0035355; GO:0042346; GO:0042495; GO:0042496; GO:0042497; GO:0042498; GO:0042535; GO:0042834; GO:0042892; GO:0044130; GO:0045087; GO:0045121; GO:0045429; GO:0045944; GO:0046982; GO:0050715; GO:0050729; GO:0050830; GO:0051092; GO:0051770; GO:0052063; GO:0060907; GO:0070374; GO:0070891; GO:0071221; GO:0071223; GO:0071224; GO:0071726; GO:0071727; GO:1901224; GO:1904417 0 0 0 PF13516;PF13855;PF01582; Q9WV48 CHOYP_LOC581773.1.1 m.56865 sp SHAN1_RAT 57.143 98 38 2 578 674 662 756 2.75E-24 115 SHAN1_RAT reviewed SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon) Shank1 Rattus norvegicus (Rat) 2167 adult behavior [GO:0030534]; associative learning [GO:0008306]; cytoskeletal anchoring at plasma membrane [GO:0007016]; dendritic spine morphogenesis [GO:0060997]; determination of affect [GO:0050894]; habituation [GO:0046959]; long-term memory [GO:0007616]; negative regulation of actin filament bundle assembly [GO:0032232]; neuromuscular process controlling balance [GO:0050885]; olfactory behavior [GO:0042048]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein complex assembly [GO:0006461]; protein localization to synapse [GO:0035418]; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311]; righting reflex [GO:0060013]; social behavior [GO:0035176]; synapse maturation [GO:0060074]; vocalization behavior [GO:0071625] GO:0005622; GO:0005737; GO:0005886; GO:0006461; GO:0007016; GO:0007616; GO:0008022; GO:0008306; GO:0008328; GO:0014069; GO:0017124; GO:0030054; GO:0030159; GO:0030160; GO:0030425; GO:0030534; GO:0031877; GO:0032232; GO:0032403; GO:0035176; GO:0035255; GO:0035418; GO:0042048; GO:0042802; GO:0043005; GO:0043197; GO:0045202; GO:0045211; GO:0046959; GO:0050885; GO:0050894; GO:0060013; GO:0060074; GO:0060076; GO:0060997; GO:0060999; GO:0071532; GO:0071625; GO:0097110; GO:2000311; GO:2000463 0 0 0 PF12796;PF16511;PF00595;PF00536;PF07653; A6BM72 CHOYP_BRAFLDRAFT_224574.8.18 m.33831 sp MEG11_HUMAN 36.7 297 166 13 32 323 372 651 2.76E-41 157 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; O42184 CHOYP_CLIP1.2.2 m.25060 sp CLIP1_CHICK 28.722 665 326 22 326 953 858 1411 2.76E-37 155 CLIP1_CHICK reviewed CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 170) (CLIP-170) (Restin) CLIP1 RSN Gallus gallus (Chicken) 1433 transport [GO:0006810] GO:0001726; GO:0005874; GO:0006810; GO:0030659; GO:0046872 0 0 0 PF01302;PF16641; O43741 CHOYP_PRKAB2.1.1 m.12513 sp AAKB2_HUMAN 59.817 219 85 2 51 269 57 272 2.76E-87 263 AAKB2_HUMAN reviewed 5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2) PRKAB2 Homo sapiens (Human) 272 carnitine shuttle [GO:0006853]; cell cycle arrest [GO:0007050]; fatty acid biosynthetic process [GO:0006633]; macroautophagy [GO:0016236]; protein phosphorylation [GO:0006468]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of protein kinase activity [GO:0045859]; regulation of signal transduction by p53 class mediator [GO:1901796]; signal transduction [GO:0007165] GO:0005654; GO:0005829; GO:0005952; GO:0006468; GO:0006633; GO:0006853; GO:0007050; GO:0007165; GO:0016236; GO:0031588; GO:0042304; GO:0042802; GO:0045859; GO:1901796 0 0 0 PF16561;PF04739; O54862 CHOYP_MBTPS2.1.1 m.7694 sp MBTP2_CRIGR 41.616 495 265 3 14 485 14 507 2.76E-139 413 MBTP2_CRIGR reviewed Membrane-bound transcription factor site-2 protease (EC 3.4.24.85) (Endopeptidase S2P) (Sterol regulatory element-binding proteins intramembrane protease) (SREBPs intramembrane protease) MBTPS2 S2P Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 510 cholesterol metabolic process [GO:0008203]; membrane protein intracellular domain proteolysis [GO:0031293]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; response to endoplasmic reticulum stress [GO:0034976] GO:0004222; GO:0005737; GO:0008203; GO:0016021; GO:0031293; GO:0034976; GO:0046872; GO:0051091; GO:1990440 0 0 0 PF02163; O70497 CHOYP_BRAFLDRAFT_86061.1.13 m.15726 sp FCN2_MOUSE 53.237 139 63 2 80 217 128 265 2.76E-42 148 FCN2_MOUSE reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Mus musculus (Mouse) 314 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of interleukin-8 secretion [GO:2000484]; protein localization to cell surface [GO:0034394]; recognition of apoptotic cell [GO:0043654]" GO:0001664; GO:0001867; GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0033691; GO:0034394; GO:0043654; GO:0046597; GO:0046872; GO:0097367; GO:2000484 0 0 0 PF01391;PF00147; P13798 CHOYP_LOC100491896.1.1 m.15901 sp ACPH_HUMAN 52.8 125 59 0 1 125 538 662 2.76E-39 142 ACPH_HUMAN reviewed Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH) APEH D3F15S2 D3S48E DNF15S2 Homo sapiens (Human) 732 beta-amyloid metabolic process [GO:0050435]; proteolysis [GO:0006508]; translational termination [GO:0006415] GO:0004252; GO:0005737; GO:0005829; GO:0006415; GO:0006508; GO:0008242; GO:0031965; GO:0044822; GO:0050435; GO:0070062 0 0 0 PF00326; P18433 CHOYP_PTPRA.7.22 m.34306 sp PTPRA_HUMAN 29.667 691 453 19 404 1075 124 800 2.76E-78 277 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P29594 CHOYP_CASP2.5.5 m.35953 sp CASP2_MOUSE 27.387 398 246 9 40 408 65 448 2.76E-38 146 CASP2_MOUSE reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] Casp2 Ich1 Nedd-2 Nedd2 Mus musculus (Mouse) 452 "aging [GO:0007568]; apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; luteolysis [GO:0001554]; negative regulation of apoptotic process [GO:0043066]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]" GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0006977; GO:0007420; GO:0007568; GO:0016020; GO:0016485; GO:0019904; GO:0035234; GO:0043065; GO:0043066; GO:0043525; GO:0071260; GO:0097153; GO:0097190; GO:0097192; GO:2001235 0 0 0 PF00619; Q03601 CHOYP_BRAFLDRAFT_69765.23.23 m.64597 sp NHL1_CAEEL 29.348 92 58 2 186 270 789 880 2.76E-06 52 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q24K15 CHOYP_LOC100543236.1.2 m.20322 sp ANGP4_BOVIN 41.045 134 74 3 78 209 283 413 2.76E-30 119 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q29RK9 CHOYP_MOB3B.2.2 m.22493 sp MOB3B_BOVIN 73.239 213 57 0 23 235 4 216 2.76E-125 356 MOB3B_BOVIN reviewed MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) MOB3B MOBKL2B Bos taurus (Bovine) 216 0 GO:0046872 0 0 0 PF03637; Q460N5 CHOYP_GSPATT00018498001.2.2 m.52082 sp PAR14_HUMAN 32.886 149 88 4 2552 2696 789 929 2.76E-12 77 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4ZJM9 CHOYP_LOC100561667.4.4 m.59904 sp C1QL4_MOUSE 35.294 136 73 6 45 176 109 233 2.76E-11 63.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q6AY78 CHOYP_LOC100177728.1.1 m.8677 sp S22AI_RAT 40.107 374 209 3 51 413 9 378 2.76E-84 266 S22AI_RAT reviewed Solute carrier family 22 member 18 (Organic cation transporter-like protein 2) (ORCTL-2) Slc22a18 Orctl2 Tssc5 Rattus norvegicus (Rat) 404 ion transport [GO:0006811] GO:0006811; GO:0015293; GO:0016021; GO:0016324 0 0 cd06174; PF07690; Q6KEQ9 CHOYP_CAD1.1.2 m.29573 sp PC11X_PIG 34.13 753 473 11 16 754 14 757 2.76E-121 400 PC11X_PIG reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) PCDH11X PCDH11 PCDHX Sus scrofa (Pig) 1117 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q7ZTZ2 CHOYP_RLP24.2.2 m.51354 sp RLP24_DANRE 72.393 163 42 2 29 190 1 161 2.76E-82 243 RLP24_DANRE reviewed Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) rsl24d1 zgc:56202 Danio rerio (Zebrafish) (Brachydanio rerio) 161 assembly of large subunit precursor of preribosome [GO:1902626]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625; GO:1902626 0 0 cd00472; PF01246; Q7ZV90 CHOYP_CHGG_05501.1.1 m.156 sp PIF1_DANRE 45 60 23 2 35 94 538 587 2.76E-06 49.7 PIF1_DANRE reviewed ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) pif1 zgc:56161 Danio rerio (Zebrafish) (Brachydanio rerio) 639 DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial genome maintenance [GO:0000002]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; telomere maintenance [GO:0000723] GO:0000002; GO:0000723; GO:0003677; GO:0005524; GO:0005634; GO:0005657; GO:0005739; GO:0006260; GO:0006281; GO:0006310; GO:0010521; GO:0032211; GO:0032508; GO:0043141; GO:0044806; GO:0051974 0 0 0 PF05970; Q7ZV90 CHOYP_LOC100890415.1.2 m.37242 sp PIF1_DANRE 29.067 375 194 15 6 368 303 617 2.76E-23 105 PIF1_DANRE reviewed ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) pif1 zgc:56161 Danio rerio (Zebrafish) (Brachydanio rerio) 639 DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; G-quadruplex DNA unwinding [GO:0044806]; mitochondrial genome maintenance [GO:0000002]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; telomere maintenance [GO:0000723] GO:0000002; GO:0000723; GO:0003677; GO:0005524; GO:0005634; GO:0005657; GO:0005739; GO:0006260; GO:0006281; GO:0006310; GO:0010521; GO:0032211; GO:0032508; GO:0043141; GO:0044806; GO:0051974 0 0 0 PF05970; Q8VIG3 CHOYP_LOC100375551.2.2 m.63720 sp RSPH1_MOUSE 66.667 213 71 0 17 229 17 229 2.76E-93 279 RSPH1_MOUSE reviewed Radial spoke head 1 homolog (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) Rsph1 Tsga2 Mus musculus (Mouse) 301 axoneme assembly [GO:0035082]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] GO:0000794; GO:0001520; GO:0005634; GO:0005737; GO:0005829; GO:0007286; GO:0031514; GO:0035082; GO:0036126; GO:0051321; GO:0072687 0 0 0 PF02493; Q99M80 CHOYP_PTPRA.20.22 m.59249 sp PTPRT_MOUSE 43.75 256 141 2 408 661 902 1156 2.76E-56 211 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BV23 CHOYP_ABH6B.1.1 m.24436 sp ABHD6_HUMAN 35.604 323 187 9 10 329 19 323 2.76E-64 210 ABHD6_HUMAN reviewed Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) ABHD6 Homo sapiens (Human) 337 acylglycerol catabolic process [GO:0046464]; long term synaptic depression [GO:0060292]; negative regulation of cell migration [GO:0030336]; phospholipid catabolic process [GO:0009395]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of endocannabinoid signaling pathway [GO:2000124] GO:0004620; GO:0005739; GO:0005886; GO:0009395; GO:0016021; GO:0030336; GO:0032281; GO:0046464; GO:0046889; GO:0047372; GO:0060292; GO:0070062; GO:2000124 0 0 0 PF00561; Q9ESN6 CHOYP_BRAFLDRAFT_242376.1.1 m.3236 sp TRIM2_MOUSE 27.801 241 151 12 67 298 506 732 2.76E-08 58.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9I9M5 CHOYP_BRAFLDRAFT_278500.1.1 m.18087 sp FZD1_XENLA 63.194 144 48 2 28 168 46 187 2.76E-57 194 FZD1_XENLA reviewed Frizzled-1 (Fz-1) (Xfz1) fzd1 fz1 Xenopus laevis (African clawed frog) 559 multicellular organism development [GO:0007275] GO:0004930; GO:0005886; GO:0007275; GO:0016021; GO:0042813 0 0 0 PF01534;PF01392; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G199235.13.15 m.57447 sp SACS_HUMAN 24.36 977 627 30 1 947 2608 3502 2.76E-69 258 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9P1Z9 CHOYP_LOC100369255.3.3 m.52809 sp CC180_HUMAN 32.815 579 381 3 1 578 202 773 2.76E-95 343 CC180_HUMAN reviewed Coiled-coil domain-containing protein 180 CCDC180 C9orf174 KIAA1529 Homo sapiens (Human) 1646 0 GO:0016021; GO:0070062 0 0 0 PF14643;PF14644; Q9R1R2 CHOYP_LOC100213744.18.19 m.54043 sp TRIM3_MOUSE 23.502 217 136 7 63 262 491 694 2.76E-06 51.6 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A0JM12 CHOYP_MEG10.32.91 m.35015 sp MEG10_XENTR 34.241 257 136 10 176 413 593 835 2.77E-24 112 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A6NE52 CHOYP_LOC100377114.1.1 m.17576 sp WDR97_HUMAN 24.792 843 546 21 46 844 76 874 2.77E-81 300 WDR97_HUMAN reviewed WD repeat-containing protein 97 WDR97 KIAA1875 Homo sapiens (Human) 1622 generation of catalytic spliceosome for second transesterification step [GO:0000350] GO:0000350; GO:0071013 0 0 0 PF00400; A7SG73 CHOYP_BRAFLDRAFT_232705.1.2 m.13912 sp NADC_NEMVE 61.21 281 109 0 39 319 9 289 2.77E-123 358 NADC_NEMVE reviewed Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (Fragment) qprt v1g117116 Nematostella vectensis (Starlet sea anemone) 289 NAD biosynthetic process [GO:0009435]; quinolinate catabolic process [GO:0034213] GO:0004514; GO:0005737; GO:0009435; GO:0034213 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1. 0 0 PF01729;PF02749; B2RRE7 CHOYP_PHYPADRAFT_165219.1.1 m.47393 sp OTUD4_MOUSE 29.104 134 73 3 268 396 39 155 2.77E-11 69.3 OTUD4_MOUSE reviewed OTU domain-containing protein 4 (EC 3.4.19.12) Otud4 Kiaa1046 Mus musculus (Mouse) 1107 protein K48-linked deubiquitination [GO:0071108] GO:0004843; GO:0044822; GO:0071108 0 0 0 PF02338; B3EWZ6 CHOYP_SI_CH211-106H4.4.1.1 m.58540 sp MLRP2_ACRMI 29.375 160 104 5 115 268 1390 1546 2.77E-14 76.3 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D2GXS7 CHOYP_LOC100373888.4.9 m.36545 sp TRIM2_AILME 25.746 268 152 12 149 399 506 743 2.77E-07 56.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2A0M0 CHOYP_NRP.3.4 m.40291 sp NRP_PINMG 23.2 250 150 9 48 290 467 681 2.77E-13 73.6 NRP_PINMG reviewed Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 686 0 GO:0005576 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_109857.14.15 m.65062 sp TRIM3_RAT 25.306 245 161 10 178 410 510 744 2.77E-08 59.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75112 CHOYP_ISCW_ISCW000210.4.4 m.38490 sp LDB3_HUMAN 41.237 97 47 4 13 105 12 102 2.77E-11 69.7 LDB3_HUMAN reviewed LIM domain-binding protein 3 (Protein cypher) (Z-band alternatively spliced PDZ-motif protein) LDB3 KIAA0613 ZASP Homo sapiens (Human) 727 sarcomere organization [GO:0045214] GO:0005856; GO:0008092; GO:0008270; GO:0030018; GO:0031143; GO:0045214; GO:0048471 0 0 0 PF15936;PF00412;PF00595; O75382 CHOYP_LOC100374342.14.19 m.53843 sp TRIM3_HUMAN 23.585 212 133 8 343 541 536 731 2.77E-08 60.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P04630 CHOYP_LOC585888.1.1 m.34050 sp CALL_CAEEL 31.159 138 87 3 360 494 22 154 2.77E-10 63.2 CALL_CAEEL reviewed Calmodulin-like protein cal-1 cmd-1 C13C12.1 Caenorhabditis elegans 161 0 GO:0005509 0 0 0 PF13499; P06603 CHOYP_TBA1.9.9 m.66132 sp TBA1_DROME 96.377 138 5 0 1 138 201 338 2.77E-94 283 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P11167 CHOYP_AGAP_AGAP007340.1.2 m.2953 sp GTR1_RAT 43.724 478 257 5 38 515 4 469 2.77E-144 427 GTR1_RAT reviewed "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)" Slc2a1 Glut-1 Glut1 Rattus norvegicus (Rat) 492 cellular response to glucose starvation [GO:0042149]; dehydroascorbic acid transport [GO:0070837]; glucose transport [GO:0015758]; protein complex assembly [GO:0006461]; response to osmotic stress [GO:0006970]; xenobiotic transport [GO:0042908] GO:0001939; GO:0005351; GO:0005355; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005901; GO:0005911; GO:0006461; GO:0006970; GO:0015758; GO:0016021; GO:0016323; GO:0016324; GO:0019900; GO:0030496; GO:0030864; GO:0033300; GO:0042149; GO:0042470; GO:0042908; GO:0042910; GO:0043621; GO:0055056; GO:0070062; GO:0070837; GO:0072562 0 0 cd06174; PF00083; P16157 CHOYP_LOC581927.24.27 m.59576 sp ANK1_HUMAN 30.592 693 440 22 353 1017 82 761 2.77E-55 214 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18433 CHOYP_LOC578838.1.1 m.42127 sp PTPRA_HUMAN 29.571 700 441 25 450 1130 119 785 2.77E-74 266 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P24367 CHOYP_PPIB.3.4 m.40801 sp PPIB_CHICK 51.892 185 78 3 29 213 33 206 2.77E-56 181 PPIB_CHICK reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207 chaperone-mediated protein folding [GO:0061077]; protein peptidyl-prolyl isomerization [GO:0000413] GO:0000413; GO:0003755; GO:0005788; GO:0032403; GO:0032991; GO:0042277; GO:0042470; GO:0061077 0 0 0 PF00160; P35950 CHOYP_BRAFLDRAFT_134943.1.1 m.4732 sp LDLR_CRIGR 57.5 40 17 0 151 190 80 119 2.77E-08 57 LDLR_CRIGR reviewed Low-density lipoprotein receptor (LDL receptor) LDLR LDLA I79_005860 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 862 cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897]; lipid transport [GO:0006869] GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005905; GO:0006869; GO:0006897; GO:0008203; GO:0009986; GO:0016021; GO:0034362 0 0 0 PF07645;PF00057;PF00058; P40305 CHOYP_LOC101242540.2.2 m.50260 sp IFI27_HUMAN 44.915 118 49 3 133 245 11 117 2.77E-16 76.6 IFI27_HUMAN reviewed "Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a))" IFI27 Homo sapiens (Human) 119 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of protein export from nucleus [GO:0046825]; type I interferon signaling pathway [GO:0060337] GO:0000122; GO:0001102; GO:0005521; GO:0005637; GO:0005739; GO:0005741; GO:0006919; GO:0016021; GO:0046825; GO:0060337; GO:0097190 0 0 0 PF06140; P48382 CHOYP_LOC100769524.1.1 m.51788 sp RFX5_HUMAN 41.441 222 119 6 50 266 34 249 2.77E-46 181 RFX5_HUMAN reviewed DNA-binding protein RFX5 (Regulatory factor X 5) RFX5 Homo sapiens (Human) 616 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000978; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006357 0 0 0 PF14621;PF02257; P62868 CHOYP_MGC89853.5.7 m.29405 sp UBIM_MUSSI 47.297 74 37 1 1 72 1 74 2.77E-16 70.5 UBIM_MUSSI reviewed Ubiquitin-like protein FUBI Fau Mus spicilegus (Steppe mouse) 74 0 0 0 0 0 PF00240; P98109 CHOYP_LOC100498354.1.1 m.58863 sp LYAM3_SHEEP 30.049 203 133 4 287 480 185 387 2.77E-24 110 LYAM3_SHEEP reviewed P-selectin (CD62 antigen-like family member P) (CD62P antigen) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62) SELP Ovis aries (Sheep) 769 cell adhesion [GO:0007155] GO:0007155; GO:0016021; GO:0030246 0 0 0 PF00059;PF00084; Q02357 CHOYP_TVAG_099270.3.6 m.54132 sp ANK1_MOUSE 26.549 226 142 5 657 879 501 705 2.77E-17 91.3 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q03958 CHOYP_NEMVEDRAFT_V1G248362.1.1 m.62940 sp PFD6_MOUSE 57.258 124 50 3 1 122 1 123 2.77E-38 128 PFD6_MOUSE reviewed Prefoldin subunit 6 (Protein Ke2) Pfdn6 H2-Ke2 Pfd6 Mus musculus (Mouse) 127 chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0006457; GO:0016272; GO:0051087; GO:0051131 0 0 0 PF01920; Q1RML7 CHOYP_LOC100377801.1.1 m.10929 sp MAK16_BOVIN 62.791 301 101 5 1 295 1 296 2.77E-120 350 MAK16_BOVIN reviewed Protein MAK16 homolog MAK16 Bos taurus (Bovine) 298 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0003676; GO:0005730; GO:0030687; GO:0044822 0 0 0 PF04874;PF01778; Q32PF0 CHOYP_LOC100720883.1.1 m.16331 sp TM201_BOVIN 46.341 164 78 3 18 173 25 186 2.77E-45 168 TM201_BOVIN reviewed Transmembrane protein 201 TMEM201 Bos taurus (Bovine) 393 nuclear migration along microtubule [GO:0030473] GO:0005521; GO:0016021; GO:0030473; GO:0031965; GO:0051015 0 0 0 PF10476;PF09779; Q3SWX9 CHOYP_RAD21.2.2 m.50047 sp RAD21_BOVIN 52.784 485 201 9 1 470 1 472 2.77E-146 441 RAD21_BOVIN reviewed Double-strand-break repair protein rad21 homolog RAD21 Bos taurus (Bovine) 630 apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168] GO:0000775; GO:0000785; GO:0001228; GO:0005654; GO:0006281; GO:0006915; GO:0007059; GO:0007067; GO:0016020; GO:0034991; GO:0051301; GO:0071168 0 0 0 PF04824;PF04825; Q502G5 CHOYP_CA050.2.2 m.50118 sp CA050_DANRE 57.463 134 55 1 6 139 56 187 2.77E-52 167 CA050_DANRE reviewed Uncharacterized protein C1orf50 homolog zgc:112255 Danio rerio (Zebrafish) (Brachydanio rerio) 189 0 0 0 0 0 PF10504; Q5F478 CHOYP_ANK2.8.8 m.62382 sp ANR44_CHICK 31.683 202 117 5 47 228 76 276 2.77E-16 83.6 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5SQN1 CHOYP_LOC100370974.1.1 m.4153 sp SNP47_HUMAN 27.494 451 285 11 3 440 42 463 2.77E-42 158 SNP47_HUMAN reviewed Synaptosomal-associated protein 47 (SNAP-47) (Epididymis luminal protein 170) (Synaptosomal-associated 47 kDa protein) SNAP47 C1orf142 HEL170 SVAP1 Homo sapiens (Human) 464 long-term synaptic potentiation [GO:0060291]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082] GO:0005484; GO:0005886; GO:0012505; GO:0016082; GO:0019905; GO:0030425; GO:0031201; GO:0031629; GO:0043025; GO:0048471; GO:0060291; GO:0098793 0 0 0 PF02893; Q62158 CHOYP_TVAG_127540.4.10 m.42416 sp TRI27_MOUSE 34.524 84 50 2 41 120 70 152 2.77E-06 48.9 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q6DFF9 CHOYP_BRAFLDRAFT_210487.1.1 m.37416 sp MABP1_XENLA 69.93 143 43 0 16 158 40 182 2.77E-67 224 MABP1_XENLA reviewed Mitogen-activated protein kinase-binding protein 1 mapkbp1 Xenopus laevis (African clawed frog) 1580 0 0 0 0 0 PF00400; Q6GNV7 CHOYP_TRIADDRAFT_60867.3.3 m.61503 sp DIRC2_XENLA 33.983 462 270 6 20 477 24 454 2.77E-77 252 DIRC2_XENLA reviewed Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) 456 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6P7L4 CHOYP_SC22B.1.1 m.62900 sp SC22B_XENTR 68.224 214 66 1 1 214 1 212 2.77E-111 320 SC22B_XENTR reviewed Vesicle-trafficking protein SEC22b (SEC22 vesicle-trafficking protein homolog B) (SEC22-like protein 1) sec22b sec22l1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 215 ER to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; vesicle fusion with Golgi apparatus [GO:0048280] GO:0000139; GO:0000149; GO:0005484; GO:0005789; GO:0006888; GO:0015031; GO:0016021; GO:0031201; GO:0033116; GO:0048280 0 0 0 PF13774;PF00957; Q8BP56 CHOYP_BRAFLDRAFT_261940.2.2 m.53422 sp ATHL1_MOUSE 36.703 643 396 7 66 697 9 651 2.77E-144 442 ATHL1_MOUSE reviewed Acid trehalase-like protein 1 (EC 3.2.1.-) Athl1 Mus musculus (Mouse) 690 carbohydrate metabolic process [GO:0005975] GO:0005618; GO:0005975; GO:0016787; GO:0016798 0 0 0 PF03632; Q8N4L8 CHOYP_LOC100366431.1.1 m.7510 sp CCD24_HUMAN 30.579 242 140 6 15 250 7 226 2.77E-19 90.9 CCD24_HUMAN reviewed Coiled-coil domain-containing protein 24 CCDC24 Homo sapiens (Human) 307 0 0 0 0 0 PF15669; Q8R1G6 CHOYP_PDLI2.3.3 m.41785 sp PDLI2_MOUSE 36.082 97 58 2 3 99 37 129 2.77E-07 55.8 PDLI2_MOUSE reviewed PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) Pdlim2 Mus musculus (Mouse) 349 0 GO:0001725; GO:0005925; GO:0008270; GO:0015629; GO:0030864; GO:0070062 0 0 0 PF15936;PF00412;PF00595; Q8VIJ8 CHOYP_LOC101174104.1.1 m.25373 sp NPRL3_MOUSE 45.61 467 222 9 4 456 111 559 2.77E-123 374 NPRL3_MOUSE reviewed Nitrogen permease regulator 3-like protein (Alpha-globin regulatory element-containing gene protein) Nprl3 Mare Mus musculus (Mouse) 569 aorta morphogenesis [GO:0035909]; cardiac muscle tissue development [GO:0048738]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TOR signaling [GO:0032007]; palate development [GO:0060021]; ventricular septum development [GO:0003281] GO:0003281; GO:0005096; GO:0032007; GO:0034198; GO:0035909; GO:0048738; GO:0060021; GO:1990130 0 0 0 PF03666; Q8WW12 CHOYP_PCNP.1.1 m.57914 sp PCNP_HUMAN 47.368 133 53 3 46 176 58 175 2.77E-32 117 PCNP_HUMAN reviewed PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) PCNP Homo sapiens (Human) 178 cell cycle [GO:0007049]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] GO:0005634; GO:0007049; GO:0016567; GO:0043161 0 0 0 PF15473; Q95LD9 CHOYP_SS.1.1 m.53185 sp AHR_DELLE 46.115 399 184 8 2 374 10 403 2.77E-109 357 AHR_DELLE reviewed Aryl hydrocarbon receptor (Ah receptor) (AhR) AHR Delphinapterus leucas (Beluga whale) 845 "cell cycle [GO:0007049]; circadian regulation of gene expression [GO:0032922]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; response to xenobiotic stimulus [GO:0009410]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0004874; GO:0005634; GO:0005737; GO:0006351; GO:0007049; GO:0009410; GO:0032922; GO:0034751; GO:0045892; GO:0045893; GO:0070888 0 0 0 PF00010;PF00989;PF08447; Q99M80 CHOYP_PTPRA.9.22 m.46545 sp PTPRT_MOUSE 30.836 694 432 17 448 1101 768 1453 2.77E-83 300 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99M80 CHOYP_PTPRE.14.19 m.49805 sp PTPRT_MOUSE 33.149 543 311 13 283 780 760 1295 2.77E-74 270 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9D9I4 CHOYP_BRAFLDRAFT_121942.1.2 m.9973 sp TBC20_MOUSE 51.955 179 86 0 38 216 30 208 2.77E-58 191 TBC20_MOUSE reviewed TBC1 domain family member 20 Tbc1d20 Mus musculus (Mouse) 402 acrosome assembly [GO:0001675]; camera-type eye development [GO:0043010]; cargo loading into COPII-coated vesicle [GO:0090110]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; lipid particle organization [GO:0034389]; male gonad development [GO:0008584]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of GTPase activity [GO:0043547]; seminiferous tubule development [GO:0072520]; spermatogenesis [GO:0007283]; virion assembly [GO:0019068] GO:0001675; GO:0002088; GO:0005096; GO:0005783; GO:0005789; GO:0006888; GO:0007030; GO:0007283; GO:0008584; GO:0017137; GO:0019068; GO:0030173; GO:0031965; GO:0034389; GO:0043010; GO:0043547; GO:0044829; GO:0046726; GO:0070309; GO:0072520; GO:0090110; GO:1902953 0 0 0 PF00566; Q9DCR2 CHOYP_LOC100118502.1.1 m.57420 sp AP3S1_MOUSE 80.105 191 31 1 1 184 1 191 2.77E-111 318 AP3S1_MOUSE reviewed AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) Ap3s1 Mus musculus (Mouse) 193 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005802; GO:0006886; GO:0008089; GO:0008565; GO:0016020; GO:0016192; GO:0030123; GO:0030659; GO:0043231; GO:0048490; GO:1904115 0 0 0 PF01217; Q9R085 CHOYP_UBP15.3.4 m.53546 sp UBP15_RAT 50 226 111 2 20 245 7 230 2.77E-61 219 UBP15_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin carboxyl-terminal hydrolase of 109 kDa) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) Usp15 ubp109 Rattus norvegicus (Rat) 952 BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; protein deubiquitination [GO:0016579]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004197; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0007179; GO:0016579; GO:0030509; GO:0035520; GO:0035616; GO:0060389 0 0 0 PF06337;PF14836;PF00443;PF14533; Q9UKN5 CHOYP_PRDM4.1.1 m.16677 sp PRDM4_HUMAN 31.818 418 238 12 468 854 353 754 2.77E-55 208 PRDM4_HUMAN reviewed PR domain zinc finger protein 4 (EC 2.1.1.-) (PR domain-containing protein 4) PRDM4 PFM1 Homo sapiens (Human) 801 "cell proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; cellular response to nutrient [GO:0031670]; histone H4-R3 methylation [GO:0043985]; negative regulation of cell growth [GO:0030308]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003677; GO:0005737; GO:0006355; GO:0006366; GO:0007165; GO:0008168; GO:0008270; GO:0008283; GO:0030308; GO:0031670; GO:0035097; GO:0043985; GO:0071363; GO:1990226 0 0 0 PF00096; Q9Y6F1 CHOYP_BRAFLDRAFT_203655.2.2 m.20185 sp PARP3_HUMAN 53.55 493 210 11 53 533 47 532 2.77E-156 459 PARP3_HUMAN reviewed Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) PARP3 ADPRT3 ADPRTL3 Homo sapiens (Human) 533 DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; lagging strand elongation [GO:0006273]; positive regulation of DNA ligation [GO:0051106]; protein ADP-ribosylation [GO:0006471]; protein localization to site of double-strand break [GO:1990166]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723] GO:0000723; GO:0003824; GO:0003910; GO:0003950; GO:0005634; GO:0005737; GO:0005814; GO:0006273; GO:0006281; GO:0006302; GO:0006471; GO:0035861; GO:0051103; GO:0051106; GO:0060236; GO:1990166 0 0 0 PF00644;PF02877;PF05406; A2AX52 CHOYP_LOC100030437.1.3 m.5994 sp CO6A4_MOUSE 24.437 577 390 12 56 616 34 580 2.78E-44 175 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A2RT62 CHOYP_PHUM_PHUM041660.1.1 m.38460 sp FXL16_MOUSE 57.403 385 161 1 87 468 95 479 2.78E-158 460 FXL16_MOUSE reviewed F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) Fbxl16 Mus musculus (Mouse) 479 0 GO:0005737 0 0 0 PF13516; A2VDD2 CHOYP_LOC100375714.2.2 m.46486 sp TC1DB_XENLA 37.5 120 72 1 29 148 40 156 2.78E-23 92.8 TC1DB_XENLA reviewed Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) 176 0 0 0 0 0 PF03645; A4IF63 CHOYP_BRAFLDRAFT_87292.2.6 m.20560 sp TRIM2_BOVIN 24.667 150 108 3 39 184 595 743 2.78E-08 56.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B0S5Y3 CHOYP_BRAFLDRAFT_92596.1.1 m.59952 sp S5A3A_DANRE 44.068 472 222 9 55 518 5 442 2.78E-114 348 S5A3A_DANRE reviewed "Solute carrier family 52, riboflavin transporter, member 3-A (Riboflavin transporter 2-A) (RFT2-A)" slc52a3a rft2a si:dkeyp-53e12.7 zgc:136909 Danio rerio (Zebrafish) (Brachydanio rerio) 448 0 GO:0005887; GO:0032217 0 0 0 PF06237; B5FZ19 CHOYP_EIF3I.1.1 m.56504 sp EIF3I_TAEGU 70.062 324 94 1 27 347 1 324 2.78E-177 497 EIF3I_TAEGU reviewed Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (eIF-3-beta) (eIF3 p36) EIF3I EIF3S2 Taeniopygia guttata (Zebra finch) (Poephila guttata) 325 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0003743; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF00400; D3ZF92 CHOYP_LOC101156914.1.1 m.30383 sp TNR21_RAT 28.188 149 95 5 36 177 70 213 2.78E-06 53.5 TNR21_RAT reviewed Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358) Tnfrsf21 Dr6 Rattus norvegicus (Rat) 655 adaptive immune response [GO:0002250]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response [GO:0006954]; myelination [GO:0042552]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of interleukin-10 secretion [GO:2001180]; negative regulation of interleukin-13 secretion [GO:2000666]; negative regulation of interleukin-5 secretion [GO:2000663]; negative regulation of myelination [GO:0031642]; negative regulation of T cell proliferation [GO:0042130]; neuron apoptotic process [GO:0051402]; oligodendrocyte apoptotic process [GO:0097252]; regulation of apoptotic process [GO:0042981]; regulation of cell proliferation [GO:0042127]; regulation of oligodendrocyte differentiation [GO:0048713]; response to lipopolysaccharide [GO:0032496]; T cell receptor signaling pathway [GO:0050852] GO:0001783; GO:0002250; GO:0005031; GO:0005887; GO:0006954; GO:0006955; GO:0006959; GO:0030424; GO:0030889; GO:0031226; GO:0031642; GO:0032496; GO:0042127; GO:0042130; GO:0042552; GO:0042981; GO:0048713; GO:0050852; GO:0051402; GO:0097190; GO:0097252; GO:2000663; GO:2000666; GO:2001180 0 0 0 PF00531;PF00020; D9IQ16 CHOYP_NEMVEDRAFT_V1G218972.1.2 m.40326 sp GXN_ACRMI 26.102 295 177 8 132 400 53 332 2.78E-18 89.4 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 F1Q4S1 CHOYP_ATP9B.2.2 m.37807 sp ATP9B_DANRE 44.167 120 55 4 14 128 22 134 2.78E-20 89 ATP9B_DANRE reviewed Probable phospholipid-transporting ATPase IIB (EC 3.6.3.1) (ATPase class II type 9B) atp9b Danio rerio (Zebrafish) (Brachydanio rerio) 1125 "endocytosis [GO:0006897]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000287; GO:0004012; GO:0005524; GO:0005768; GO:0005802; GO:0005886; GO:0006890; GO:0006897; GO:0016021 0 0 0 PF00122;PF16212;PF16209; O12947 CHOYP_EF-1A.1.9 m.5613 sp ICMT_XENLA 43.415 205 109 1 15 219 4 201 2.78E-49 166 ICMT_XENLA reviewed Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Farnesyl cysteine carboxyl methyltransferase) (FCMT) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) icmt Xenopus laevis (African clawed frog) 288 0 GO:0004671; GO:0005789; GO:0016021 0 0 0 PF04140; O15990 CHOYP_KARG.4.11 m.5400 sp KARG_LIOJA 64.286 126 44 1 22 147 146 270 2.78E-51 169 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O17583 CHOYP_LOC100868101.1.1 m.57213 sp LIN10_CAEEL 67.332 401 110 4 775 1158 585 981 2.78E-180 558 LIN10_CAEEL reviewed Protein lin-10 (Abnormal cell lineage protein 10) lin-10 C09H6.2 Caenorhabditis elegans 982 asymmetric protein localization [GO:0008105]; nervous system development [GO:0007399]; neuron-neuron synaptic transmission [GO:0007270]; positive regulation of vulval development [GO:0040026]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to early endosome [GO:1902946]; receptor localization to synapse [GO:0097120]; sensory perception of touch [GO:0050975]; transport [GO:0006810] GO:0000138; GO:0005737; GO:0005794; GO:0005886; GO:0006810; GO:0007270; GO:0007399; GO:0008105; GO:0017137; GO:0030054; GO:0030140; GO:0030425; GO:0032580; GO:0040026; GO:0043005; GO:0043025; GO:0045202; GO:0050975; GO:0097120; GO:1902946; GO:1903361 0 0 0 PF00595;PF00640; O42387 CHOYP_RS24.1.6 m.1042 sp RS24_TAKRU 81.452 124 23 0 5 128 4 127 2.78E-71 212 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O60462 CHOYP_NRP2.8.8 m.65376 sp NRP2_HUMAN 29.707 239 141 10 62 287 49 273 2.78E-20 95.9 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O70277 CHOYP_BRAFLDRAFT_87336.5.9 m.27374 sp TRIM3_RAT 27.559 127 85 3 4 128 622 743 2.78E-09 57.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O93327 CHOYP_BRAFLDRAFT_276131.1.1 m.46672 sp H2AY_CHICK 53.96 202 89 2 3 200 170 371 2.78E-73 228 H2AY_CHICK reviewed Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) H2AFY Gallus gallus (Chicken) 372 "chromatin silencing [GO:0006342]; covalent chromatin modification [GO:0016569]; dosage compensation [GO:0007549]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of histone H3-K27 methylation [GO:0061086]; negative regulation of histone H3-K4 methylation [GO:0051572]; negative regulation of histone phosphorylation [GO:0033128]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of keratinocyte differentiation [GO:0045618]; regulation of histone methylation [GO:0031060]; regulation of lipid metabolic process [GO:0019216]" GO:0000122; GO:0000182; GO:0000784; GO:0000786; GO:0000790; GO:0000793; GO:0000979; GO:0003677; GO:0005721; GO:0005730; GO:0006334; GO:0006342; GO:0007549; GO:0010385; GO:0016569; GO:0019216; GO:0030291; GO:0031060; GO:0031490; GO:0033128; GO:0035098; GO:0045618; GO:0045815; GO:0051572; GO:0061086; GO:0070062; GO:0071169; GO:1901837; GO:1902750 0 0 0 PF00125;PF16211;PF01661; P16157 CHOYP_TVAG_451090.3.13 m.23361 sp ANK1_HUMAN 38.095 273 169 0 1 273 226 498 2.78E-50 181 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20397 CHOYP_NUCL.2.2 m.21719 sp NUCL_XENLA 33.929 336 146 6 42 321 171 486 2.78E-29 123 NUCL_XENLA reviewed Nucleolin (Protein C23) ncl Xenopus laevis (African clawed frog) 651 0 GO:0000166; GO:0003677; GO:0003723; GO:0005730 0 0 0 PF00076; P30602 CHOYP_KKV.1.1 m.13427 sp CHS3_EXODE 26.316 418 234 18 601 944 366 783 2.78E-20 101 CHS3_EXODE reviewed Chitin synthase 3 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 3) (Class-III chitin synthase 3) CHS3 Exophiala dermatitidis (Black yeast) (Wangiella dermatitidis) 885 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0071555 0 0 0 PF01644;PF08407; P36975 CHOYP_LOC100533400.3.4 m.28214 sp SNP25_DROME 58.706 201 78 2 18 216 15 212 2.78E-77 234 SNP25_DROME reviewed Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) Snap25 CG40452 Drosophila melanogaster (Fruit fly) 212 Golgi to plasma membrane transport [GO:0006893]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] GO:0000149; GO:0005484; GO:0005737; GO:0005886; GO:0006893; GO:0006906; GO:0007269; GO:0007274; GO:0016020; GO:0016081; GO:0016082; GO:0016192; GO:0019905; GO:0030054; GO:0031201; GO:0031629; GO:0043195; GO:0048172; GO:0048489 0 0 0 PF00835; P49013 CHOYP_LOC100634060.5.37 m.15781 sp FBP3_STRPU 52.459 183 87 0 1 183 241 423 2.78E-58 194 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P58365 CHOYP_LOC100114931.1.1 m.4848 sp CAD23_RAT 31.074 605 377 19 86 685 87 656 2.78E-67 248 CAD23_RAT reviewed Cadherin-23 (Otocadherin) Cdh23 Rattus norvegicus (Rat) 3317 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0005509; GO:0005886; GO:0007156; GO:0007605; GO:0007626; GO:0016021; GO:0032420; GO:0045177; GO:0047485; GO:0060122 0 0 0 PF00028; P62890 CHOYP_LOC659206.5.6 m.39119 sp RL30_RAT 82.301 113 20 0 72 184 1 113 2.78E-65 199 RL30_RAT reviewed 60S ribosomal protein L30 Rpl30 Rattus norvegicus (Rat) 115 liver regeneration [GO:0097421]; positive regulation of selenocysteine incorporation [GO:1904571]; selenocysteine metabolic process [GO:0016259]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005829; GO:0005840; GO:0005925; GO:0006412; GO:0016020; GO:0016259; GO:0022625; GO:0035368; GO:0070062; GO:0097421; GO:1904571 0 0 0 PF01248; P79942 CHOYP_LOC100556517.1.1 m.22221 sp NOCT_XENLA 44.548 321 164 7 7 320 67 380 2.78E-87 270 NOCT_XENLA reviewed Nocturnin (EC 3.1.13.4) (Carbon catabolite repression 4-like protein) (Circadian deadenylase NOC) (Rhythmic message 1) (RM1) noct ccrn4l Xenopus laevis (African clawed frog) 388 mRNA processing [GO:0006397]; rhythmic process [GO:0048511] GO:0004535; GO:0006397; GO:0046872; GO:0048511 0 0 0 PF03372; Q0P4P2 CHOYP_LOC100543236.2.2 m.66500 sp FBCD1_XENTR 42.478 226 120 4 68 286 230 452 2.78E-55 188 FBCD1_XENTR reviewed Fibrinogen C domain-containing protein 1 fibcd1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 457 0 GO:0008061; GO:0016021; GO:0046872 0 0 0 PF00147; Q29K06 CHOYP_GTPBA.1.1 m.60956 sp GTPBA_DROPS 44.384 365 194 4 90 446 10 373 2.78E-87 275 GTPBA_DROPS reviewed GTP-binding protein 10 homolog GA10450 Drosophila pseudoobscura pseudoobscura (Fruit fly) 383 ribosome biogenesis [GO:0042254] GO:0000287; GO:0003924; GO:0005525; GO:0005730; GO:0042254 0 0 0 PF01018;PF01926; Q2KHM9 CHOYP_LOC100377435.1.1 m.46017 sp MOONR_HUMAN 31.496 381 200 11 5 365 31 370 2.78E-31 136 MOONR_HUMAN reviewed Protein moonraker (MNR) KIAA0753 MNR Homo sapiens (Human) 967 centriole replication [GO:0007099]; protein localization to centrosome [GO:0071539] GO:0005737; GO:0005813; GO:0007099; GO:0034451; GO:0071539 0 0 0 PF15718; Q3ULM6 CHOYP_LOC100891926.1.1 m.2934 sp USPL1_MOUSE 29.279 222 132 9 6 205 46 264 2.78E-12 68.2 USPL1_MOUSE reviewed SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) Uspl1 Mus musculus (Mouse) 1089 Cajal body organization [GO:0030576]; cell proliferation [GO:0008283]; protein desumoylation [GO:0016926] GO:0005615; GO:0008283; GO:0015030; GO:0016926; GO:0030576; GO:0032183; GO:0070140 0 0 0 PF15509;PF15499; Q5YCC5 CHOYP_BRAFLDRAFT_199751.1.2 m.23055 sp TMC7_CHICK 36.294 653 390 9 116 759 91 726 2.78E-131 410 TMC7_CHICK reviewed Transmembrane channel-like protein 7 Tmc7 Gallus gallus (Chicken) 735 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q78ZA7 CHOYP_CPNE8.2.2 m.58380 sp NP1L4_MOUSE 63.345 281 93 3 50 329 27 298 2.78E-113 336 NP1L4_MOUSE reviewed Nucleosome assembly protein 1-like 4 Nap1l4 Mus musculus (Mouse) 375 nucleosome assembly [GO:0006334] GO:0005634; GO:0006334; GO:0044822 0 0 0 PF00956; Q8BJ56 CHOYP_LOC100865198.1.1 m.48508 sp PLPL2_MOUSE 43.108 399 204 6 45 441 9 386 2.78E-104 328 PLPL2_MOUSE reviewed Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Desnutrin) Pnpla2 Atgl Mus musculus (Mouse) 486 lipid homeostasis [GO:0055088]; lipid particle organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of sequestering of triglyceride [GO:0010891]; positive regulation of triglyceride catabolic process [GO:0010898]; triglyceride catabolic process [GO:0019433] GO:0004806; GO:0005811; GO:0005829; GO:0005886; GO:0010891; GO:0010898; GO:0016020; GO:0016021; GO:0019433; GO:0019915; GO:0034389; GO:0055088 PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. 0 0 PF01734; Q93XW5 CHOYP_CHLREDRAFT_64643.1.1 m.35271 sp NSP5_ARATH 32.515 163 103 4 5 166 4 160 2.78E-22 94.4 NSP5_ARATH reviewed Nitrile-specifier protein 5 (AtNSP5) NSP5 At5g48180 MIF21.7 Arabidopsis thaliana (Mouse-ear cress) 326 glucosinolate catabolic process [GO:0019762]; nitrile biosynthetic process [GO:0080028] GO:0005829; GO:0019762; GO:0080028 0 0 0 PF01344; Q99NH0 CHOYP_LOC754728.1.6 m.7352 sp ANR17_MOUSE 29.936 471 282 16 351 807 248 684 2.78E-41 167 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BVR0 CHOYP_LOC100370069.7.14 m.52310 sp HRC23_HUMAN 42.667 75 38 2 288 360 591 662 2.78E-07 56.6 HRC23_HUMAN reviewed Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) 1158 0 GO:0004842; GO:0046872 0 0 0 PF06701; Q9JKL7 CHOYP_LOC100370236.1.3 m.7766 sp SREK1_RAT 57.333 150 63 1 136 284 41 190 2.78E-51 188 SREK1_RAT reviewed "Splicing regulatory glutamine/lysine-rich protein 1 (SR-related protein of 86 kDa) (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12)" Srek1 Sfrs12 Srrp86 Rattus norvegicus (Rat) 494 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0003676; GO:0005681; GO:0006397; GO:0008380 0 0 0 PF00076; Q9MYM7 CHOYP_LOC100879808.1.1 m.54411 sp B3GT1_PONPY 32.941 170 109 3 75 240 79 247 2.78E-29 115 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9R1R2 CHOYP_BRAFLDRAFT_99973.6.8 m.52734 sp TRIM3_MOUSE 28.455 123 84 3 30 149 622 743 2.78E-08 55.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UHN1 CHOYP_POLG2.1.1 m.16377 sp DPOG2_HUMAN 28.281 442 233 10 2 380 59 479 2.78E-44 162 DPOG2_HUMAN reviewed "DNA polymerase subunit gamma-2, mitochondrial (EC 2.7.7.7) (DNA polymerase gamma accessory 55 kDa subunit) (p55) (Mitochondrial DNA polymerase accessory subunit) (MtPolB) (PolG-beta)" POLG2 MTPOLB Homo sapiens (Human) 485 DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; glycyl-tRNA aminoacylation [GO:0006426]; in utero embryonic development [GO:0001701]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; respiratory electron transport chain [GO:0022904] GO:0000262; GO:0001701; GO:0003677; GO:0003887; GO:0004820; GO:0005759; GO:0006260; GO:0006261; GO:0006281; GO:0006426; GO:0007005; GO:0022904; GO:0032042; GO:0042645; GO:0070062; GO:0070584 0 0 0 PF03129; A8E5W8 CHOYP_LOC581387.1.1 m.56997 sp F166B_XENTR 26.49 302 168 11 23 291 17 297 2.79E-19 89.4 F166B_XENTR reviewed Protein FAM166B fam166b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 306 0 0 0 0 0 PF10629; B3A0P4 CHOYP_USP26.1.1 m.27285 sp USP26_LOTGI 33.858 127 74 3 369 492 50 169 2.79E-18 85.5 USP26_LOTGI reviewed Uncharacterized shell protein 26 (BMSP-like protein) (Fragment) 0 Lottia gigantea (Giant owl limpet) 173 0 GO:0005576 0 0 0 0 O42401 CHOYP_BRAFLDRAFT_99629.3.4 m.45204 sp MATN3_CHICK 29.221 154 98 7 2 149 79 227 2.79E-09 63.9 MATN3_CHICK reviewed Matrilin-3 MATN3 Gallus gallus (Chicken) 452 0 GO:0005509; GO:0005578 0 0 0 PF07645;PF10393;PF00092; O46470 CHOYP_LOC655987.1.3 m.18926 sp RGS7_BOVIN 58.333 408 158 5 9 412 58 457 2.79E-171 491 RGS7_BOVIN reviewed Regulator of G-protein signaling 7 (RGS7) RGS7 Bos taurus (Bovine) 469 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968] GO:0004871; GO:0005096; GO:0005737; GO:0005829; GO:0005834; GO:0005886; GO:0007186; GO:0009968; GO:0035556 0 0 cd00068; PF00610;PF00631;PF00615; O75445 CHOYP_BRAFLDRAFT_121500.1.1 m.14277 sp USH2A_HUMAN 37.021 235 147 1 1 235 2922 3155 2.79E-45 165 USH2A_HUMAN reviewed Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF02210;PF00055; O94273 CHOYP_PPIB.2.4 m.40019 sp PPIB_SCHPO 47.12 191 90 3 5 195 8 187 2.79E-54 176 PPIB_SCHPO reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin 4) (Rotamase B) cyp4 SPBP8B7.25 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 201 protein folding [GO:0006457] GO:0003755; GO:0005783; GO:0005788; GO:0005794; GO:0006457; GO:0042277 0 0 0 PF00160; P41777 CHOYP_LOC100117990.2.2 m.63595 sp NOLC1_RAT 70.37 81 24 0 650 730 624 704 2.79E-31 134 NOLC1_RAT reviewed Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) Nolc1 Rattus norvegicus (Rat) 704 "box H/ACA snoRNA metabolic process [GO:0033979]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of protein import into nucleus [GO:0042306]; response to osmotic stress [GO:0006970]" GO:0003700; GO:0005524; GO:0005525; GO:0005654; GO:0005730; GO:0005737; GO:0006970; GO:0008134; GO:0008139; GO:0008284; GO:0019904; GO:0033979; GO:0034512; GO:0034513; GO:0042306; GO:0045893 0 0 0 PF05022; P51523 CHOYP_XFIN.2.4 m.9976 sp ZNF84_HUMAN 25.503 298 156 13 211 469 263 533 2.79E-08 60.8 ZNF84_HUMAN reviewed Zinc finger protein 84 (Zinc finger protein HPF2) ZNF84 Homo sapiens (Human) 738 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 cd07765; PF01352;PF00096;PF13912; P56079 CHOYP_DANA_GF23961.1.1 m.1800 sp CDSA_DROME 59.848 264 87 3 1 245 1 264 2.79E-112 332 CDSA_DROME reviewed "Phosphatidate cytidylyltransferase, photoreceptor-specific (EC 2.7.7.41) (CDP-DAG synthase) (CDP-DG synthase) (CDP-diacylglycerol synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase)" CdsA CG7962 Drosophila melanogaster (Fruit fly) 447 "CDP-diacylglycerol biosynthetic process [GO:0016024]; cell growth [GO:0016049]; lipid storage [GO:0019915]; phosphatidylglycerol biosynthetic process [GO:0006655]; phototransduction [GO:0007602]; regulation of lipid storage [GO:0010883]; rhodopsin mediated signaling pathway [GO:0016056]; terminal branching, open tracheal system [GO:0007430]; thermotaxis [GO:0043052]; trachea morphogenesis [GO:0060439]; visual perception [GO:0007601]" GO:0004605; GO:0005789; GO:0005886; GO:0006655; GO:0007430; GO:0007601; GO:0007602; GO:0010883; GO:0016021; GO:0016024; GO:0016049; GO:0016056; GO:0019915; GO:0043052; GO:0060439 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. 0 0 0 P61129 CHOYP_ZC3H4.1.1 m.57516 sp ZC3H6_HUMAN 30.097 515 249 21 450 903 277 741 2.79E-37 157 ZC3H6_HUMAN reviewed Zinc finger CCCH domain-containing protein 6 ZC3H6 KIAA2035 ZC3HDC6 Homo sapiens (Human) 1189 0 GO:0046872 0 0 0 PF00642; P62752 CHOYP_RLA0.7.7 m.66734 sp RL23A_RAT 62.264 53 20 0 62 114 29 81 2.79E-12 62.8 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; Q14432 CHOYP_PDE3A.2.3 m.23023 sp PDE3A_HUMAN 43.373 166 73 5 29 180 620 778 2.79E-34 132 PDE3A_HUMAN reviewed "cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)" PDE3A Homo sapiens (Human) 1141 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933]; cellular response to cGMP [GO:0071321]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP-mediated signaling [GO:0019934]; diterpenoid metabolic process [GO:0016101]; lipid metabolic process [GO:0006629]; negative regulation of apoptotic process [GO:0043066]; negative regulation of vascular permeability [GO:0043116]; oocyte maturation [GO:0001556]; positive regulation of oocyte development [GO:0060282]; positive regulation of vascular permeability [GO:0043117]; regulation of meiotic nuclear division [GO:0040020]; response to cAMP [GO:0051591]; response to drug [GO:0042493] GO:0001556; GO:0004115; GO:0004119; GO:0005829; GO:0006198; GO:0006629; GO:0016021; GO:0016101; GO:0019933; GO:0019934; GO:0030552; GO:0040020; GO:0042493; GO:0043066; GO:0043116; GO:0043117; GO:0046872; GO:0047555; GO:0051591; GO:0060282; GO:0071321; GO:0071560 0 0 0 PF00233; Q3KPT0 CHOYP_LOC100375592.5.6 m.59283 sp CC169_XENLA 44.828 145 78 2 16 160 17 159 2.79E-32 119 CC169_XENLA reviewed Coiled-coil domain-containing protein 169 ccdc169 Xenopus laevis (African clawed frog) 214 0 0 0 0 0 PF15372; Q3T0C9 CHOYP_LOC100182131.1.1 m.26023 sp SYJ2B_BOVIN 43.662 142 60 4 31 172 21 142 2.79E-24 95.5 SYJ2B_BOVIN reviewed Synaptojanin-2-binding protein (Activin receptor-interacting protein 2) (Mitochondrial outer membrane protein 25) SYNJ2BP ARIP2 OMP25 Bos taurus (Bovine) 145 endocytosis [GO:0006897]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sprouting angiogenesis [GO:1903671]; regulation of Notch signaling pathway [GO:0008593] GO:0001937; GO:0005741; GO:0006897; GO:0008593; GO:0010596; GO:0016021; GO:0016525; GO:0048471; GO:0070373; GO:1903671 0 0 0 PF00595; Q460N5 CHOYP_BRAFLDRAFT_74874.9.9 m.63747 sp PAR14_HUMAN 20.27 592 426 12 219 790 189 754 2.79E-14 81.3 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4R5Y0 CHOYP_BRAFLDRAFT_123540.1.1 m.10582 sp CK001_MACFA 41.727 139 69 2 1 139 19 145 2.79E-31 112 CK001_MACFA reviewed UPF0686 protein C11orf1 homolog QtsA-19889 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 150 0 GO:0005634 0 0 0 PF06608; Q5BIM1 CHOYP_BRAFLDRAFT_83265.1.2 m.36902 sp TRI45_BOVIN 23.824 340 216 9 35 341 37 366 2.79E-19 94.7 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5R8E2 CHOYP_LOC100369926.5.6 m.55530 sp KLC3_PONAB 27.815 151 104 5 444 592 262 409 2.79E-07 57.4 KLC3_PONAB reviewed Kinesin light chain 3 KLC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 504 0 GO:0003777; GO:0005737; GO:0005871; GO:0005874 0 0 0 0 Q60787 CHOYP_LCP2.4.14 m.15732 sp LCP2_MOUSE 36.296 135 83 2 446 577 389 523 2.79E-19 94.7 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q7T3B2 CHOYP_BRAFLDRAFT_270304.1.1 m.29206 sp HRG1A_DANRE 33.333 132 85 3 31 161 8 137 2.79E-17 77.4 HRG1A_DANRE reviewed Heme transporter hrg1-A (zHRG-1) (Heme-responsive gene 1 protein homolog A) (HRG-1A) (Solute carrier family 48 member 1-B) slc48a1b hrg1a zgc:63994 Danio rerio (Zebrafish) (Brachydanio rerio) 144 erythrocyte development [GO:0048821] GO:0005765; GO:0010008; GO:0015232; GO:0016021; GO:0048821 0 0 0 PF16954; Q7TNC8 CHOYP_GLRA1.1.1 m.31710 sp GLRA2_MOUSE 39.43 421 217 8 35 435 39 441 2.79E-97 302 GLRA2_MOUSE reviewed Glycine receptor subunit alpha-2 Glra2 Mus musculus (Mouse) 452 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; response to amino acid [GO:0043200]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0007218; GO:0007416; GO:0016594; GO:0016934; GO:0021510; GO:0022852; GO:0030054; GO:0034220; GO:0034707; GO:0042995; GO:0043200; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; Q7XA86 CHOYP_LOC590681.2.2 m.53138 sp ZDH11_ARATH 33.465 254 139 7 46 280 63 305 2.79E-30 120 ZDH11_ARATH reviewed Protein S-acyltransferase 10 (EC 2.3.1.225) (Probable palmitoyltransferase At3g51390) (Zinc finger DHHC domain-containing protein At3g51390) PAT10 At3g51390 F26O13.30 Arabidopsis thaliana (Mouse-ear cress) 340 0 GO:0005774; GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q80ZA4 CHOYP_BRAFLDRAFT_118430.2.2 m.44188 sp PKHL1_MOUSE 26.718 262 176 8 4 258 3918 4170 2.79E-08 60.8 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8R4E0 CHOYP_IRF1.1.3 m.52606 sp IRF2_SIGHI 50.435 115 53 1 121 231 2 116 2.79E-36 144 IRF2_SIGHI reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Sigmodon hispidus (Hispid cotton rat) 349 "cell proliferation [GO:0008283]; transcription, DNA-templated [GO:0006351]" GO:0000975; GO:0003700; GO:0005634; GO:0006351; GO:0008283 0 0 0 PF00605; Q8VIP2 CHOYP_MLXIP.2.3 m.14630 sp MLXPL_RAT 63.776 196 71 0 695 890 661 856 2.79E-74 264 MLXPL_RAT reviewed Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) Mlxipl Wbscr14 Rattus norvegicus (Rat) 865 "cellular response to glucose stimulus [GO:0071333]; energy reserve metabolic process [GO:0006112]; fatty acid homeostasis [GO:0055089]; regulation of energy homeostasis [GO:2000505]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to glucose [GO:0009749]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006110; GO:0006112; GO:0006351; GO:0006357; GO:0009749; GO:0019901; GO:0035538; GO:0042304; GO:0043565; GO:0055089; GO:0071333; GO:2000505 0 0 0 PF00010; Q96I25 CHOYP_SPF45.1.1 m.22111 sp SPF45_HUMAN 48.182 440 150 14 1 404 1 398 2.79E-102 312 SPF45_HUMAN reviewed Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) RBM17 SPF45 Homo sapiens (Human) 401 "alternative mRNA splicing, via spliceosome [GO:0000380]" GO:0000166; GO:0000380; GO:0003723; GO:0005681 0 0 0 PF01585;PF00076; Q9BU19 CHOYP_LOC417340.1.1 m.60346 sp ZN692_HUMAN 45.098 51 28 0 200 250 11 61 2.79E-07 56.6 ZN692_HUMAN reviewed Zinc finger protein 692 ZNF692 Homo sapiens (Human) 519 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q9CZJ2 CHOYP_LOC100372773.8.9 m.64045 sp HS12B_MOUSE 24.146 439 264 11 1 378 237 667 2.79E-25 111 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D7M8 CHOYP_LOC100711617.1.1 m.9209 sp RPB4_MOUSE 75.342 146 32 1 1 146 1 142 2.79E-75 223 RPB4_MOUSE reviewed DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) Polr2d Mus musculus (Mouse) 142 "mRNA export from nucleus in response to heat stress [GO:0031990]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; piRNA metabolic process [GO:0034587]; positive regulation of translational initiation [GO:0045948]; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [GO:0034402]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000166; GO:0000288; GO:0000932; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0006366; GO:0006367; GO:0031369; GO:0031990; GO:0034402; GO:0034587; GO:0045948 0 0 0 PF03874; Q9UDR5 CHOYP_LOC100906268.1.2 m.32482 sp AASS_HUMAN 47.493 379 198 1 16 393 481 859 2.79E-119 370 AASS_HUMAN reviewed "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Homo sapiens (Human) 926 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine catabolic process [GO:0006554]; protein tetramerization [GO:0051262] GO:0005739; GO:0005759; GO:0006554; GO:0033512; GO:0043231; GO:0047130; GO:0047131; GO:0051262 PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.; PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. 0 0 PF05222;PF16653;PF03435; A4IF63 CHOYP_LOC100373444.55.79 m.52378 sp TRIM2_BOVIN 25.726 241 128 7 338 528 468 707 2.80E-14 79.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B1AWJ5 CHOYP_LOC100560017.1.2 m.5714 sp TMM8B_MOUSE 49.565 230 114 2 13 241 205 433 2.80E-67 219 TMM8B_MOUSE reviewed Transmembrane protein 8B (Protein NGX6) Tmem8b Mus musculus (Mouse) 472 cell-matrix adhesion [GO:0007160]; regulation of growth [GO:0040008] GO:0005634; GO:0005739; GO:0005783; GO:0005886; GO:0007160; GO:0009986; GO:0016021; GO:0040008 0 0 0 PF12036; D2GXS7 CHOYP_BRAFLDRAFT_205965.23.43 m.45026 sp TRIM2_AILME 28.8 125 86 2 68 192 622 743 2.80E-09 62 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E9Q555 CHOYP_RN213.5.13 m.34256 sp RN213_MOUSE 25.147 680 457 17 60 723 4496 5139 2.80E-55 209 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O43301 CHOYP_BRAFLDRAFT_208436.31.32 m.64885 sp HS12A_HUMAN 28.056 638 376 18 14 581 48 672 2.80E-68 236 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O70277 CHOYP_LOC100368020.25.29 m.47068 sp TRIM3_RAT 23.016 126 95 2 56 181 115 238 2.80E-07 52.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75175 CHOYP_LOC100049807.1.1 m.52322 sp CNOT3_HUMAN 60.687 262 73 6 461 721 520 752 2.80E-98 322 CNOT3_HUMAN reviewed CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) CNOT3 KIAA0691 LENG2 NOT3 Homo sapiens (Human) 753 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; gene silencing by RNA [GO:0031047]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; trophectodermal cell differentiation [GO:0001829]" GO:0000288; GO:0000289; GO:0000932; GO:0001829; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0006977; GO:0017148; GO:0030014; GO:0030015; GO:0031047; GO:2000036 0 0 0 PF04153;PF04065; O75382 CHOYP_BRAFLDRAFT_71595.2.4 m.36031 sp TRIM3_HUMAN 23.166 259 183 9 328 576 480 732 2.80E-09 63.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P07898 CHOYP_ASGR1.2.2 m.26608 sp PGCA_CHICK 34.328 134 78 5 18 147 1891 2018 2.80E-18 84 PGCA_CHICK reviewed Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Gallus gallus (Chicken) 2109 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; P16157 CHOYP_LOC578679.2.6 m.21464 sp ANK1_HUMAN 33.177 639 398 1 415 1024 82 720 2.80E-101 355 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20735 CHOYP_GGT1.2.2 m.64336 sp GGT1_PIG 45.656 541 283 8 82 620 37 568 2.80E-163 481 GGT1_PIG reviewed Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] GGT1 GGT Sus scrofa (Pig) 568 glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; zymogen activation [GO:0031638] GO:0003840; GO:0005886; GO:0006536; GO:0006750; GO:0006751; GO:0016021; GO:0031638; GO:0036374 PATHWAY: Sulfur metabolism; glutathione metabolism. 0 0 PF01019; P22680 CHOYP_LOC100565509.1.1 m.59171 sp CP7A1_HUMAN 30.426 516 310 15 1 481 1 502 2.80E-65 222 CP7A1_HUMAN reviewed Cholesterol 7-alpha-monooxygenase (EC 1.14.14.23) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cytochrome P450 7A1) CYP7A1 CYP7 Homo sapiens (Human) 504 bile acid biosynthetic process [GO:0006699]; cellular response to cholesterol [GO:0071397]; cellular response to glucose stimulus [GO:0071333]; cholesterol catabolic process [GO:0006707]; cholesterol homeostasis [GO:0042632]; regulation of bile acid biosynthetic process [GO:0070857]; sterol metabolic process [GO:0016125] GO:0005506; GO:0005789; GO:0006699; GO:0006707; GO:0008123; GO:0016125; GO:0020037; GO:0031090; GO:0042632; GO:0043231; GO:0070857; GO:0071333; GO:0071397 PATHWAY: Lipid metabolism; bile acid biosynthesis. 0 0 PF00067; Q13263 CHOYP_TRI45.12.23 m.33388 sp TIF1B_HUMAN 24.39 164 110 3 2 162 143 295 2.80E-08 55.8 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q15154 CHOYP_LOC581113.1.2 m.5767 sp PCM1_HUMAN 43.243 74 36 3 106 179 195 262 2.80E-08 58.2 PCM1_HUMAN reviewed Pericentriolar material 1 protein (PCM-1) (hPCM-1) PCM1 Homo sapiens (Human) 2024 centrosome organization [GO:0051297]; cilium assembly [GO:0042384]; cytoplasmic microtubule organization [GO:0031122]; G2/M transition of mitotic cell cycle [GO:0000086]; interkinetic nuclear migration [GO:0022027]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; microtubule anchoring [GO:0034453]; microtubule anchoring at centrosome [GO:0034454]; negative regulation of neurogenesis [GO:0050768]; neuronal stem cell population maintenance [GO:0097150]; neuron migration [GO:0001764]; nonmotile primary cilium assembly [GO:0035058]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to centrosome [GO:0071539] GO:0000086; GO:0000242; GO:0001764; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0016020; GO:0022027; GO:0031122; GO:0031965; GO:0034451; GO:0034453; GO:0034454; GO:0035058; GO:0035735; GO:0035869; GO:0036064; GO:0042384; GO:0042802; GO:0043234; GO:0050768; GO:0051297; GO:0071539; GO:0090316; GO:0097150 0 0 0 PF15717; Q1ZXD6 CHOYP_ROCO6.1.1 m.59689 sp ROCO5_DICDI 25.74 338 201 13 411 743 1337 1629 2.80E-15 85.5 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q24119 CHOYP_TRH.1.1 m.56051 sp TRH_DROME 50.439 456 176 5 65 474 79 530 2.80E-133 429 TRH_DROME reviewed Protein trachealess trh CG6883 Drosophila melanogaster (Fruit fly) 1022 "dendrite morphogenesis [GO:0048813]; epithelial cell fate determination, open tracheal system [GO:0007425]; epithelial tube formation [GO:0072175]; lateral inhibition [GO:0046331]; limb development [GO:0060173]; Malpighian tubule morphogenesis [GO:0007443]; open tracheal system development [GO:0007424]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; salivary gland development [GO:0007431]; salivary gland morphogenesis [GO:0007435]; spiracle morphogenesis, open tracheal system [GO:0035277]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000981; GO:0003700; GO:0005634; GO:0006366; GO:0007424; GO:0007425; GO:0007431; GO:0007435; GO:0007443; GO:0035277; GO:0043565; GO:0045944; GO:0046331; GO:0046982; GO:0048813; GO:0060173; GO:0072175 0 0 0 PF00989;PF08447; Q24K15 CHOYP_BRAFLDRAFT_59661.2.6 m.20671 sp ANGP4_BOVIN 40.789 228 125 6 240 464 275 495 2.80E-55 194 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q3ZCL5 CHOYP_LOC100373374.1.1 m.7546 sp ARFP2_BOVIN 52.77 343 136 3 12 354 23 339 2.80E-113 335 ARFP2_BOVIN reviewed Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) ARFIP2 Bos taurus (Bovine) 341 regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; ruffle organization [GO:0031529] GO:0005737; GO:0031529; GO:0034315 0 0 0 PF06456; Q460N5 CHOYP_LOC101170686.1.1 m.14516 sp PAR14_HUMAN 28.462 130 86 1 273 402 1013 1135 2.80E-12 72.4 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4GXU6 CHOYP_RS4.8.11 m.43599 sp RS4_CARGR 81.443 97 18 0 15 111 3 99 2.80E-51 166 RS4_CARGR reviewed 40S ribosomal protein S4 RpS4 Carabus granulatus (Ground beetle) 261 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q5R611 CHOYP_BRAFLDRAFT_119296.12.16 m.50238 sp HRSL3_PONAB 32.68 153 95 3 22 173 2 147 2.80E-18 80.5 HRSL3_PONAB reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) PLA2G16 HRASLS3 HREV107 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 162 lipid catabolic process [GO:0016042] GO:0004623; GO:0008970; GO:0016021; GO:0016042; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; Q5U5M8 CHOYP_ISCW_ISCW004420.3.8 m.10516 sp BL1S3_MOUSE 27.684 177 108 4 7 172 13 180 2.80E-08 54.7 BL1S3_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) (Reduced pigmentation protein) Bloc1s3 Blos3 Rp Mus musculus (Mouse) 195 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to drug [GO:0042493]; secretion of lysosomal enzymes [GO:0033299] GO:0001654; GO:0005737; GO:0005829; GO:0007596; GO:0008089; GO:0008320; GO:0016197; GO:0030133; GO:0030168; GO:0031083; GO:0031175; GO:0032402; GO:0032438; GO:0032816; GO:0033299; GO:0035646; GO:0042493; GO:0043473; GO:0048066; GO:0048490; GO:0060155; GO:1904115 0 0 0 PF15753; Q6P5M2 CHOYP_WDR61.2.2 m.28594 sp WDR61_DANRE 73.026 304 82 0 15 318 1 304 2.80E-170 477 WDR61_DANRE reviewed WD repeat-containing protein 61 wdr61 zgc:77675 Danio rerio (Zebrafish) (Brachydanio rerio) 305 positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0005634; GO:0005737; GO:0016593; GO:0032968; GO:0035327; GO:0045944; GO:0055087 0 0 0 PF00400; Q7TPD3 CHOYP_DVIR_GJ19783.1.3 m.13425 sp ROBO2_MOUSE 28.235 170 107 9 4 164 152 315 2.80E-07 55.5 ROBO2_MOUSE reviewed Roundabout homolog 2 Robo2 Kiaa1568 Mus musculus (Mouse) 1470 axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; brain development [GO:0007420]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; metanephros development [GO:0001656]; negative regulation of negative chemotaxis [GO:0050925]; olfactory bulb interneuron development [GO:0021891]; positive regulation of axonogenesis [GO:0050772]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; ureteric bud development [GO:0001657] GO:0001656; GO:0001657; GO:0005886; GO:0007156; GO:0007411; GO:0007420; GO:0009986; GO:0016021; GO:0016199; GO:0021891; GO:0030673; GO:0031290; GO:0035385; GO:0042802; GO:0050772; GO:0050925; GO:0070062 0 0 0 PF00041;PF07679; Q80ZF8 CHOYP_LOC101077846.1.2 m.35599 sp AGRB3_MOUSE 25.436 688 405 19 237 856 514 1161 2.80E-54 210 AGRB3_MOUSE reviewed Adhesion G protein-coupled receptor B3 (Brain-specific angiogenesis inhibitor 3) Adgrb3 Bai3 Mus musculus (Mouse) 1522 cell surface receptor signaling pathway [GO:0007166]; maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; myoblast fusion [GO:0007520]; negative regulation of angiogenesis [GO:0016525]; neuron remodeling [GO:0016322]; positive regulation of synapse assembly [GO:0051965]; regulation of dendrite morphogenesis [GO:0048814] GO:0004930; GO:0005096; GO:0005886; GO:0007166; GO:0007520; GO:0016021; GO:0016322; GO:0016525; GO:0043083; GO:0048814; GO:0051965; GO:0061743; GO:0098794; GO:0099558 0 0 0 PF00002;PF16489;PF01825;PF02793;PF00090; Q8IT98 CHOYP_RS18.4.11 m.20898 sp RS18_ARGIR 90.132 152 15 0 1 152 1 152 2.80E-103 295 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8N8K9 CHOYP_LOC100769984.2.2 m.47977 sp K1958_HUMAN 25.279 269 185 9 72 329 419 682 2.80E-13 75.5 K1958_HUMAN reviewed Uncharacterized protein KIAA1958 KIAA1958 Homo sapiens (Human) 716 0 GO:0000981; GO:0003677; GO:0005654; GO:0005737 0 0 0 PF12012; Q8NFD2 CHOYP_LOC100641729.8.10 m.49233 sp ANKK1_HUMAN 38.931 131 80 0 252 382 396 526 2.80E-21 99.4 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8TCU5 CHOYP_LOC657839.1.1 m.40384 sp NMD3A_HUMAN 33.333 492 312 9 43 521 473 961 2.80E-87 294 NMD3A_HUMAN reviewed "Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)" GRIN3A KIAA1973 Homo sapiens (Human) 1115 calcium ion transport [GO:0006816]; dendrite development [GO:0016358]; prepulse inhibition [GO:0060134]; response to ethanol [GO:0045471] GO:0004972; GO:0005234; GO:0005262; GO:0006816; GO:0014069; GO:0016020; GO:0016021; GO:0016358; GO:0016594; GO:0017146; GO:0030054; GO:0042802; GO:0043005; GO:0043025; GO:0045202; GO:0045211; GO:0045471; GO:0051721; GO:0060134 0 0 0 PF00060;PF10613; Q91XQ5 CHOYP_CHST15.1.3 m.16211 sp CHSTF_MOUSE 34.591 318 184 6 230 527 245 558 2.80E-52 189 CHSTF_MOUSE reviewed Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) Chst15 Brag Galnac4s6st Kiaa0598 Mus musculus (Mouse) 561 hexose biosynthetic process [GO:0019319] GO:0000139; GO:0016021; GO:0019319; GO:0050656; GO:0050659 0 0 0 0 Q95LL8 CHOYP_LOC100376902.1.1 m.20391 sp EFC12_MACFA 27.5 200 115 7 35 226 25 202 2.80E-09 60.1 EFC12_MACFA reviewed EF-hand calcium-binding domain-containing protein 12 EFCAB12 QtsA-20224 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 569 0 GO:0005509 0 0 0 0 Q96RW7 CHOYP_DVIR_GJ19783.2.3 m.23905 sp HMCN1_HUMAN 25.371 741 448 31 74 748 2048 2749 2.80E-32 141 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99PU7 CHOYP_BAP1.1.1 m.43607 sp BAP1_MOUSE 49.016 508 199 14 1 451 1 505 2.80E-145 440 BAP1_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4) Bap1 Kiaa0272 Mus musculus (Mouse) 728 monoubiquitinated histone H2A deubiquitination [GO:0035522]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of cell proliferation [GO:0008285]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; regulation of cell cycle [GO:0051726]; regulation of cell growth [GO:0001558]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001558; GO:0003682; GO:0004843; GO:0005634; GO:0005654; GO:0005737; GO:0006511; GO:0008285; GO:0016579; GO:0035517; GO:0035520; GO:0035522; GO:0051726; GO:0071108; GO:1903955 0 0 0 PF01088; Q9ESN6 CHOYP_LOC100373444.29.79 m.32651 sp TRIM2_MOUSE 23.832 214 118 8 172 341 490 702 2.80E-06 52.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JK81 CHOYP_LOC100698240.1.4 m.1242 sp MYG1_MOUSE 59.587 339 134 2 2 337 27 365 2.80E-149 428 MYG1_MOUSE reviewed "UPF0160 protein MYG1, mitochondrial (Protein Gamm1)" Myg1 Mus musculus (Mouse) 380 locomotory exploration behavior [GO:0035641] GO:0005634; GO:0005654; GO:0005739; GO:0035641; GO:0070062 0 0 0 PF03690; Q9JK81 CHOYP_LOC100698240.2.4 m.14965 sp MYG1_MOUSE 59.587 339 134 2 2 337 27 365 2.80E-149 428 MYG1_MOUSE reviewed "UPF0160 protein MYG1, mitochondrial (Protein Gamm1)" Myg1 Mus musculus (Mouse) 380 locomotory exploration behavior [GO:0035641] GO:0005634; GO:0005654; GO:0005739; GO:0035641; GO:0070062 0 0 0 PF03690; Q9VN14 CHOYP_LOC100902807.2.4 m.17669 sp CONT_DROME 34.328 1072 642 25 153 1200 323 1356 2.80E-176 561 CONT_DROME reviewed Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) 1390 axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nerve maturation [GO:0021682]; septate junction assembly [GO:0019991] GO:0005886; GO:0005918; GO:0008366; GO:0019991; GO:0021682; GO:0031225; GO:0045197; GO:0060857; GO:0061343 0 0 0 PF00041;PF00047;PF00059; A1ZA47 CHOYP_SMP_006860.2.1.4 m.8660 sp ZASP_DROME 39.655 116 67 2 1 114 1 115 2.81E-20 90.1 ZASP_DROME reviewed PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) 2194 muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952] GO:0001725; GO:0001952; GO:0003779; GO:0005915; GO:0005925; GO:0005927; GO:0008270; GO:0015629; GO:0016323; GO:0030018; GO:0030239; GO:0031252; GO:0045177; GO:0045178; GO:0051371; GO:0061061 0 0 0 PF15936;PF00412;PF00595; A4IF63 CHOYP_LOC100374741.80.83 m.64698 sp TRIM2_BOVIN 26.786 224 134 8 221 431 536 742 2.81E-10 66.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B3EWZ3 CHOYP_LOC100210677.2.8 m.3988 sp CADN_ACRMI 41.86 430 214 6 439 865 167 563 2.81E-90 325 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; B6RSP1 CHOYP_LOC593558.3.4 m.36843 sp PKHA7_DANRE 38.577 267 128 4 1 239 1 259 2.81E-49 196 PKHA7_DANRE reviewed Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) (Heart adapter protein 1) plekha7 hadp1 Danio rerio (Zebrafish) (Brachydanio rerio) 1197 cardiac muscle cell differentiation [GO:0055007]; epithelial cell-cell adhesion [GO:0090136]; regulation of heart contraction [GO:0008016]; zonula adherens maintenance [GO:0045218] GO:0005737; GO:0005813; GO:0005915; GO:0008016; GO:0045218; GO:0055007; GO:0070097; GO:0090136 0 0 0 PF00169;PF00397; O08848 CHOYP_VATG.1.2 m.4408 sp RO60_MOUSE 29.897 97 68 0 4 100 24 120 2.81E-09 55.8 RO60_MOUSE reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0034336; GO:0046872; GO:0060271 0 0 0 PF05731; O42115 CHOYP_PHUM_PHUM165720.1.1 m.32029 sp ARX_DANRE 52.222 90 38 2 8 93 184 272 2.81E-22 97.1 ARX_DANRE reviewed Aristaless-related homeobox protein (ARX) arx Danio rerio (Zebrafish) (Brachydanio rerio) 453 "neuron development [GO:0048666]; pancreatic A cell development [GO:0003322]; regulation of transcription, DNA-templated [GO:0006355]; subthalamus development [GO:0021539]; transcription, DNA-templated [GO:0006351]" GO:0003322; GO:0005634; GO:0006351; GO:0006355; GO:0021539; GO:0043565; GO:0048666 0 0 0 PF00046;PF03826; P04323 CHOYP_LOC578054.7.7 m.65402 sp POL3_DROME 39.914 466 262 7 1077 1531 165 623 2.81E-94 333 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P10079 CHOYP_LOC100632098.9.13 m.38437 sp FBP1_STRPU 51.494 435 211 0 1 435 430 864 2.81E-143 438 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P25228 CHOYP_LOC100533330.2.2 m.6070 sp RAB3_DROME 85.906 149 21 0 1 149 1 149 2.81E-91 266 RAB3_DROME reviewed Ras-related protein Rab-3 Rab3 CG7576 Drosophila melanogaster (Fruit fly) 220 cytoskeletal matrix organization at active zone [GO:0048789]; exocytosis [GO:0006887]; maintenance of presynaptic active zone structure [GO:0048790]; neurotransmitter secretion [GO:0007269]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; regulation of synaptic vesicle fusion to presynaptic membrane [GO:0031630]; vesicle-mediated transport [GO:0016192] GO:0003924; GO:0005525; GO:0006887; GO:0007269; GO:0008021; GO:0015031; GO:0016192; GO:0030054; GO:0031630; GO:0031982; GO:0032482; GO:0045202; GO:0048172; GO:0048786; GO:0048789; GO:0048790 0 0 0 PF00071; P33450 CHOYP_NEMVEDRAFT_V1G122785.1.1 m.57840 sp FAT_DROME 25.748 936 633 29 13 919 2778 3680 2.81E-51 202 FAT_DROME reviewed Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito] ft CG3352 Drosophila melanogaster (Fruit fly) 5147 "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell morphogenesis involved in differentiation [GO:0000904]; cell proliferation [GO:0008283]; equator specification [GO:0045317]; establishment of body hair planar orientation [GO:0048105]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of Wnt signaling pathway [GO:0030178]; ommatidial rotation [GO:0016318]; peptide cross-linking [GO:0018149]; pupal development [GO:0035209]; regulation of growth [GO:0040008]; regulation of imaginal disc growth [GO:0045570]; regulation of organ growth [GO:0046620]; regulation of protein localization [GO:0032880]; regulation of tube length, open tracheal system [GO:0035159]; single organismal cell-cell adhesion [GO:0016337]; tissue development [GO:0009888]; wing disc development [GO:0035220]" GO:0000904; GO:0001736; GO:0001737; GO:0004872; GO:0005509; GO:0005739; GO:0005887; GO:0007156; GO:0007157; GO:0007164; GO:0007446; GO:0007447; GO:0007476; GO:0008283; GO:0008285; GO:0009888; GO:0010629; GO:0016021; GO:0016318; GO:0016324; GO:0016336; GO:0016337; GO:0016339; GO:0018149; GO:0030178; GO:0032880; GO:0035159; GO:0035209; GO:0035220; GO:0035329; GO:0040008; GO:0042067; GO:0044331; GO:0045198; GO:0045296; GO:0045317; GO:0045570; GO:0045571; GO:0045926; GO:0046620; GO:0048105; GO:0050839; GO:0090176 0 0 0 PF00028;PF00008;PF00054;PF02210; P59222 CHOYP_MEG10.40.91 m.40809 sp SREC2_MOUSE 43.443 122 61 6 185 305 311 425 2.81E-17 87.4 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P78314 CHOYP_3BP2.1.3 m.3359 sp 3BP2_HUMAN 28.261 138 84 5 11 141 10 139 2.81E-08 58.9 3BP2_HUMAN reviewed SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) 561 signal transduction [GO:0007165] GO:0005070; GO:0007165 0 0 0 PF00169;PF00017; Q0IHI4 CHOYP_PPIB.3.4 m.40802 sp TIPIN_XENLA 37.113 97 57 2 6 102 10 102 2.81E-10 59.7 TIPIN_XENLA reviewed TIMELESS-interacting protein (XTipin) tipin Xenopus laevis (African clawed frog) 360 cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint [GO:0000076]; intra-S DNA damage checkpoint [GO:0031573]; mitotic nuclear division [GO:0007067]; positive regulation of cell proliferation [GO:0008284]; replication fork protection [GO:0048478] GO:0000076; GO:0000790; GO:0005634; GO:0005737; GO:0007067; GO:0008284; GO:0031573; GO:0044770; GO:0048478; GO:0051301 0 0 0 PF07962; Q2EY13 CHOYP_BRAFLDRAFT_78749.5.5 m.65281 sp PRTGB_DANRE 24.837 306 189 15 317 603 124 407 2.81E-06 54.3 PRTGB_DANRE reviewed Protogenin B (Fragment) prtgb Danio rerio (Zebrafish) (Brachydanio rerio) 1069 multicellular organism development [GO:0007275] GO:0007275; GO:0016021 0 0 0 PF00041;PF07679; Q2M2T5 CHOYP_LOC100890106.1.1 m.40543 sp COMD1_BOVIN 39.326 178 105 2 13 190 7 181 2.81E-48 158 COMD1_BOVIN reviewed COMM domain-containing protein 1 COMMD1 Bos taurus (Bovine) 188 "copper ion homeostasis [GO:0055070]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of sodium ion transmembrane transport [GO:1902306]; positive regulation of protein ubiquitination [GO:0031398]; protein transport [GO:0015031]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; transcription, DNA-templated [GO:0006351]" GO:0005507; GO:0005634; GO:0005737; GO:0005768; GO:0005769; GO:0006351; GO:0010008; GO:0015031; GO:0016023; GO:0031398; GO:0031462; GO:0032088; GO:0032434; GO:0055037; GO:0055070; GO:1902306; GO:2000009 0 0 0 PF07258; Q4ZJM9 CHOYP_C1QL2.32.32 m.64434 sp C1QL4_MOUSE 34.314 102 63 2 54 153 113 212 2.81E-09 57.8 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q502W6 CHOYP_BRAFLDRAFT_117157.1.3 m.7944 sp VWA3B_HUMAN 40.353 679 394 5 69 741 27 700 2.81E-165 528 VWA3B_HUMAN reviewed von Willebrand factor A domain-containing protein 3B VWA3B Homo sapiens (Human) 1294 0 0 0 0 0 PF15057;PF13768; Q6GLA1 CHOYP_MSD4.1.1 m.37792 sp MSD4_XENTR 35.443 79 50 1 4 82 6 83 2.81E-07 50.1 MSD4_XENTR reviewed Myb/SANT-like DNA-binding domain-containing protein 4 msantd4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 408 0 0 0 0 0 PF13873; Q6ZNA5 CHOYP_LOC100370941.1.1 m.59883 sp FRRS1_HUMAN 33.903 351 202 8 38 372 198 534 2.81E-55 196 FRRS1_HUMAN reviewed Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 SDFR2 SDR2 Homo sapiens (Human) 592 0 GO:0000293; GO:0016021; GO:0046872 0 0 cd08544; PF03351;PF02014; Q87040 CHOYP_LOC100494384.1.1 m.24356 sp POL_SFVCP 23.355 304 200 9 141 444 200 470 2.81E-08 60.8 POL_SFVCP reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Simian foamy virus (isolate chimpanzee) (SFVcpz) 1146 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; Q8C525 CHOYP_LOC100377311.13.14 m.57319 sp M21D2_MOUSE 22.874 341 223 10 45 379 28 334 2.81E-16 85.1 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8WV92 CHOYP_LOC589308.1.1 m.30128 sp MITD1_HUMAN 55.696 237 104 1 10 246 13 248 2.81E-99 293 MITD1_HUMAN reviewed MIT domain-containing protein 1 MITD1 Homo sapiens (Human) 249 cell separation after cytokinesis [GO:0000920]; mitotic cytokinesis [GO:0000281]; negative regulation of protein binding [GO:0032091]; transport [GO:0006810] GO:0000281; GO:0000920; GO:0006810; GO:0019898; GO:0019904; GO:0030496; GO:0031902; GO:0032091; GO:0035091; GO:0042803; GO:0043231; GO:0070062 0 0 0 PF04212;PF16565; Q9BYV9 CHOYP_LOC100167826.2.2 m.36729 sp BACH2_HUMAN 26.718 131 88 4 6 131 13 140 2.81E-07 57.8 BACH2_HUMAN reviewed Transcription regulator protein BACH2 (BTB and CNC homolog 2) BACH2 Homo sapiens (Human) 841 protein ubiquitination [GO:0016567]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000980; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006366; GO:0016567; GO:0031463 0 0 0 PF00651;PF03131; Q9JK41 CHOYP_DPSE_GA20368.1.1 m.6272 sp COPT1_RAT 32.877 146 76 2 2 125 29 174 2.81E-13 67.8 COPT1_RAT reviewed High affinity copper uptake protein 1 (Copper transporter 1) (rCTR1) (Liver regeneration-related protein LRRGT00200) (Solute carrier family 31 member 1) Slc31a1 Copt1 Ctr1 Rattus norvegicus (Rat) 187 cellular copper ion homeostasis [GO:0006878]; cellular response to cisplatin [GO:0072719]; copper ion import [GO:0015677]; copper ion import into cell [GO:1902861]; drug transmembrane transport [GO:0006855] GO:0005375; GO:0005737; GO:0005770; GO:0005886; GO:0006855; GO:0006878; GO:0015088; GO:0015677; GO:0016021; GO:0043025; GO:0055037; GO:0072719; GO:1902861 0 0 0 PF04145; Q9JLC8 CHOYP_LOC100024323.1.1 m.53221 sp SACS_MOUSE 28.292 1686 1073 48 105 1708 90 1721 2.81E-166 572 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9N0C5 CHOYP_TK2.1.1 m.11341 sp KITM_MACFA 52.195 205 98 0 57 261 52 256 2.81E-78 240 KITM_MACFA reviewed "Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)" TK2 QccE-13136 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 265 DNA biosynthetic process [GO:0071897] GO:0004797; GO:0005524; GO:0005739; GO:0071897 0 0 0 PF01712; Q9R1R2 CHOYP_BRAFLDRAFT_71752.1.4 m.32465 sp TRIM3_MOUSE 25 180 123 7 197 373 536 706 2.81E-06 52.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9U505 CHOYP_LOC100914229.1.1 m.22003 sp AT5G_MANSE 63.636 132 35 3 1 122 1 129 2.81E-45 146 AT5G_MANSE reviewed "ATP synthase lipid-binding protein, mitochondrial (ATPase protein 9) (ATPase subunit c)" 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 131 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0008289; GO:0015078; GO:0015986; GO:0015991; GO:0016021; GO:0031966; GO:0045263 0 0 0 PF00137; D2GXS7 CHOYP_BRAFLDRAFT_79377.3.30 m.13483 sp TRIM2_AILME 35.802 81 50 2 29 108 627 706 2.82E-08 53.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2A0K6 CHOYP_VRP.4.4 m.66571 sp VRP_PINMG 44.082 245 122 5 26 266 1 234 2.82E-37 139 VRP_PINMG reviewed Valine-rich protein (Alveoline-like protein) 0 Pinctada margaritifera (Black-lipped pearl oyster) 238 0 GO:0005576 0 0 0 0 O15034 CHOYP_RIMB1.2.5 m.36772 sp RIMB2_HUMAN 37.634 465 237 10 748 1204 167 586 2.82E-75 276 RIMB2_HUMAN reviewed RIMS-binding protein 2 (RIM-BP2) RIMBP2 KIAA0318 RBP2 Homo sapiens (Human) 1052 negative regulation of phosphatase activity [GO:0010923] GO:0005886; GO:0010923; GO:0030054; GO:0045202 0 0 0 PF07653;PF14604; O15050 CHOYP_BRAFLDRAFT_118709.4.4 m.64071 sp TRNK1_HUMAN 34.348 920 503 16 1 848 984 1874 2.82E-157 515 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_88222.2.6 m.32706 sp TRIM3_RAT 25.926 189 109 6 14 187 515 687 2.82E-07 53.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_DAPLE.3.3 m.59589 sp TRIM3_RAT 27.068 133 87 4 14 139 614 743 2.82E-07 52.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC101169131.2.2 m.32499 sp TRIM3_RAT 28.095 210 131 9 131 328 506 707 2.82E-11 68.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_MEG11.16.25 m.47144 sp MEGF6_HUMAN 41.935 62 31 3 32 89 696 756 2.82E-06 52.8 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P09324 CHOYP_SRC1.1.1 m.63625 sp YES_CHICK 52.361 487 218 9 18 499 58 535 2.82E-172 499 YES_CHICK reviewed Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) YES1 YES Gallus gallus (Chicken) 541 cell differentiation [GO:0030154]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ephrin receptor signaling pathway [GO:0048013]; glucose transport [GO:0015758]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell proliferation [GO:0042127]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004715; GO:0005102; GO:0005524; GO:0005794; GO:0005815; GO:0005829; GO:0005884; GO:0005925; GO:0007169; GO:0015758; GO:0030154; GO:0031234; GO:0036120; GO:0038083; GO:0042127; GO:0045087; GO:0045944; GO:0048013; GO:0050731; GO:0070062; GO:0071300; GO:0071560 0 0 0 PF07714;PF00017;PF00018; P11678 CHOYP_BRAFLDRAFT_125550.2.5 m.17898 sp PERE_HUMAN 33.468 741 418 23 1 694 1 713 2.82E-116 368 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P20825 CHOYP_LOC100894010.5.6 m.35545 sp POL2_DROME 36.364 297 166 5 158 433 101 395 2.82E-44 169 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P27473 CHOYP_BRAFLDRAFT_91636.4.11 m.45350 sp IFI44_PANTR 27.891 441 263 14 23 449 24 423 2.82E-46 169 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P42573 CHOYP_LOC100185724.1.2 m.4030 sp CED3_CAEEL 34.694 147 62 7 221 352 232 359 2.82E-09 62.8 CED3_CAEEL reviewed Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 C48D1.2 Caenorhabditis elegans 503 apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; embryo development ending in birth or egg hatching [GO:0009792]; execution phase of apoptosis [GO:0097194]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; regulation of apoptotic process [GO:0042981]; regulation of cell adhesion [GO:0030155] GO:0004175; GO:0004197; GO:0005737; GO:0006915; GO:0009792; GO:0012501; GO:0016020; GO:0016540; GO:0030155; GO:0030163; GO:0042802; GO:0042981; GO:0048471; GO:0097194; GO:0097200; GO:1902742 0 0 0 PF00619; Q04202 CHOYP_LOC101238723.1.2 m.2695 sp TCB2_CAEBR 29.204 113 67 4 139 245 57 162 2.82E-06 50.8 TCB2_CAEBR reviewed Transposable element Tcb2 transposase 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; Q0IH24 CHOYP_NEMVEDRAFT_V1G125875.1.3 m.11371 sp SPEF1_XENLA 41.772 237 118 3 15 245 4 226 2.82E-49 164 SPEF1_XENLA reviewed Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) 229 0 GO:0005737; GO:0005930 0 0 0 PF06294; Q15424 CHOYP_LOC100540564.1.1 m.9507 sp SAFB1_HUMAN 80.612 98 19 0 128 225 389 486 2.82E-49 178 SAFB1_HUMAN reviewed Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) SAFB HAP HET SAFB1 Homo sapiens (Human) 915 "chromatin organization [GO:0006325]; growth [GO:0040007]; hormone metabolic process [GO:0042445]; intracellular estrogen receptor signaling pathway [GO:0030520]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of mRNA processing [GO:0050684]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0001047; GO:0003682; GO:0003690; GO:0005634; GO:0005654; GO:0006325; GO:0006351; GO:0030520; GO:0040007; GO:0042445; GO:0043565; GO:0044822; GO:0045944; GO:0050684 0 0 0 PF00076;PF02037; Q15477 CHOYP_SKIV2L.2.4 m.7861 sp SKIV2_HUMAN 67.38 187 61 0 39 225 550 736 2.82E-85 278 SKIV2_HUMAN reviewed Helicase SKI2W (Ski2) (EC 3.6.4.-) (Helicase-like protein) (HLP) SKIV2L DDX13 SKI2W SKIV2 W Homo sapiens (Human) 1246 RNA catabolic process [GO:0006401] GO:0003723; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0006401; GO:0055087 0 0 0 PF00270;PF08148;PF00271;PF13234; Q25414 CHOYP_5HTR.1.1 m.64867 sp 5HTR_LYMST 52.358 424 145 8 39 411 89 506 2.82E-142 418 5HTR_LYMST reviewed 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 509 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q4R8M9 CHOYP_BRAFLDRAFT_124130.1.3 m.6834 sp GTSF1_MACFA 43.421 76 41 1 8 81 10 85 2.82E-15 75.5 GTSF1_MACFA reviewed Gametocyte-specific factor 1 (Protein FAM112B) GTSF1 FAM112B QtsA-12026 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 167 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0005737; GO:0007283; GO:0030154; GO:0046872 0 0 0 PF05253; Q4R8V8 CHOYP_BRAFLDRAFT_120008.1.1 m.12083 sp CP100_MACFA 51.429 105 51 0 1 105 503 607 2.82E-25 101 CP100_MACFA reviewed Cilia- and flagella-associated protein 100 (Coiled-coil domain-containing protein 37) CFAP100 CCDC37 QtsA-11340 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 608 0 0 0 0 0 PF13863; Q5PQR5 CHOYP_ISCW_ISCW000262.1.1 m.25757 sp IMP4_RAT 62.42 157 59 0 12 168 12 168 2.82E-74 228 IMP4_RAT reviewed U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) Imp4 Rattus norvegicus (Rat) 291 rRNA processing [GO:0006364] GO:0006364; GO:0030515; GO:0032040; GO:0034457; GO:0042134 0 0 0 PF04427; Q5XGI5 CHOYP_LOC100372814.1.1 m.11783 sp WDR83_XENTR 59.386 293 118 1 12 304 13 304 2.82E-132 381 WDR83_XENTR reviewed WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1) wdr83 morg1 TGas070i04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 314 0 GO:0005737 0 0 0 PF00400; Q61532 CHOYP_LOC100377214.1.1 m.11174 sp MK06_MOUSE 54.79 334 143 4 16 346 13 341 2.82E-119 377 MK06_MOUSE reviewed Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) Mapk6 Erk3 Prkm4 Prkm6 Mus musculus (Mouse) 720 cell cycle [GO:0007049]; positive regulation of dendritic spine development [GO:0060999]; protein phosphorylation [GO:0006468] GO:0004672; GO:0004707; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007049; GO:0019901; GO:0032156; GO:0043234; GO:0046982; GO:0060999 0 0 0 PF00069; Q64337 CHOYP_NEMVEDRAFT_V1G239529.1.2 m.20849 sp SQSTM_MOUSE 34 100 53 1 1 87 1 100 2.82E-07 56.6 SQSTM_MOUSE reviewed Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62) Sqstm1 A170 STAP Mus musculus (Mouse) 442 apoptotic process [GO:0006915]; autophagy [GO:0006914]; cell differentiation [GO:0030154]; immune system process [GO:0002376]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein phosphorylation [GO:0001934]; protein heterooligomerization [GO:0051291]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of protein complex stability [GO:0061635]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000122; GO:0000407; GO:0000932; GO:0001934; GO:0002376; GO:0003712; GO:0005080; GO:0005737; GO:0005770; GO:0005776; GO:0005783; GO:0006511; GO:0006914; GO:0006915; GO:0008270; GO:0016234; GO:0016235; GO:0016236; GO:0016239; GO:0016605; GO:0019901; GO:0030154; GO:0031410; GO:0031625; GO:0042169; GO:0042802; GO:0043122; GO:0043130; GO:0044130; GO:0044753; GO:0044754; GO:0051291; GO:0061635; GO:0070062; GO:0070530; GO:0097225; GO:0098779 0 0 0 PF00564;PF00569; Q6DFQ7 CHOYP_LOC100376630.1.1 m.58724 sp TM198_XENTR 38.929 280 161 2 49 318 25 304 2.82E-66 215 TM198_XENTR reviewed Transmembrane protein 198 tmem198 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 342 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005886; GO:0007275; GO:0012506; GO:0016021; GO:0016023; GO:0016055 0 0 0 PF13886; Q6GNM0 CHOYP_LOC100691474.1.1 m.152 sp NRM_XENLA 28.108 185 114 6 51 221 78 257 2.82E-10 62.4 NRM_XENLA reviewed Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) nrm Xenopus laevis (African clawed frog) 285 0 GO:0005635; GO:0005637; GO:0016021 0 0 0 0 Q6NVE9 CHOYP_PPTC7.1.1 m.6671 sp PPTC7_MOUSE 59.925 267 105 1 36 302 42 306 2.82E-111 327 PPTC7_MOUSE reviewed Protein phosphatase PTC7 homolog (EC 3.1.3.16) (T-cell activation protein phosphatase 2C) (TA-PP2C) Pptc7 Tapp2c Mus musculus (Mouse) 310 0 GO:0004721; GO:0005739; GO:0046872 0 0 0 PF07228; Q6P9U1 CHOYP_NUD22.1.1 m.16809 sp NUD22_RAT 45.993 287 142 6 5 286 6 284 2.82E-78 243 NUD22_RAT reviewed Nucleoside diphosphate-linked moiety X motif 22 (Nudix motif 22) Nudt22 Rattus norvegicus (Rat) 308 0 GO:0005654; GO:0016787 0 0 0 0 Q6VVD7 CHOYP_SOX8.1.1 m.27059 sp SOX8_XENLA 56.538 260 92 11 46 293 58 308 2.82E-75 246 SOX8_XENLA reviewed Transcription factor Sox-8 sox8 Xenopus laevis (African clawed frog) 459 "neural crest formation [GO:0014029]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0005634; GO:0006351; GO:0014029 0 0 0 PF00505;PF12444; Q7SXE4 CHOYP_BRAFLDRAFT_154839.1.1 m.13878 sp GOGA5_DANRE 41.318 789 393 18 1 753 1 755 2.82E-162 491 GOGA5_DANRE reviewed Golgin subfamily A member 5 (Golgin-84) golga5 Danio rerio (Zebrafish) (Brachydanio rerio) 760 "Golgi organization [GO:0007030]; Golgi vesicle transport [GO:0048193]; retrograde transport, vesicle recycling within Golgi [GO:0000301]" GO:0000139; GO:0000301; GO:0005794; GO:0007030; GO:0016021; GO:0031985; GO:0042803; GO:0048193 0 0 0 PF09787; Q7Z442 CHOYP_LOC100378512.3.6 m.43700 sp PK1L2_HUMAN 24.958 589 396 9 2 587 1855 2400 2.82E-55 206 PK1L2_HUMAN reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) PKD1L2 KIAA1879 PC1L2 Homo sapiens (Human) 2459 detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q80YV2 CHOYP_NIPA.1.1 m.13987 sp NIPA_MOUSE 32.646 291 172 6 55 333 71 349 2.82E-36 145 NIPA_MOUSE reviewed Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (mNIPA) (Zinc finger C3HC-type protein 1) Zc3hc1 Nipa Mus musculus (Mouse) 501 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; protein ubiquitination [GO:0016567] GO:0005634; GO:0007067; GO:0008270; GO:0016567; GO:0019901; GO:0031965; GO:0051301; GO:2001240 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF08600;PF07967; Q8CHW1 CHOYP_LOC100376482.3.7 m.10316 sp THAP1_MOUSE 41.573 89 37 4 14 100 5 80 2.82E-09 61.2 THAP1_MOUSE reviewed THAP domain-containing protein 1 Thap1 Mus musculus (Mouse) 210 "cell cycle [GO:0007049]; endothelial cell proliferation [GO:0001935]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001935; GO:0005634; GO:0005730; GO:0006351; GO:0006355; GO:0007049; GO:0007346; GO:0008270; GO:0016605; GO:0042802; GO:0043231; GO:0043565 0 0 0 PF05485; Q8JZL3 CHOYP_LOC100705726.1.1 m.17900 sp THTPA_MOUSE 39.444 180 94 4 239 405 6 183 2.82E-29 116 THTPA_MOUSE reviewed Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28) Thtpa Mus musculus (Mouse) 224 dephosphorylation [GO:0016311]; thiamine diphosphate metabolic process [GO:0042357]; thiamine metabolic process [GO:0006772] GO:0000287; GO:0005737; GO:0006772; GO:0016311; GO:0042357; GO:0050333 0 0 0 PF01928; Q98943 CHOYP_LOC100892193.5.5 m.62378 sp CASP2_CHICK 28.238 386 250 8 57 421 40 419 2.82E-39 149 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9CQ66 CHOYP_LOC100636687.1.1 m.37541 sp TC1D2_MOUSE 37.607 117 71 1 99 213 26 142 2.82E-21 89 TC1D2_MOUSE reviewed Tctex1 domain-containing protein 2 Tctex1d2 Mus musculus (Mouse) 144 0 0 0 0 0 PF03645; Q9CZJ2 CHOYP_HSPA12A.27.27 m.65384 sp HS12B_MOUSE 29.291 635 374 19 1094 1661 59 685 2.82E-72 260 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9NUQ2 CHOYP_AGPAT5.1.1 m.30215 sp PLCE_HUMAN 40.054 367 214 4 23 387 2 364 2.82E-107 322 PLCE_HUMAN reviewed 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon) AGPAT5 Homo sapiens (Human) 364 CDP-diacylglycerol biosynthetic process [GO:0016024]; hematopoietic progenitor cell differentiation [GO:0002244]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; triglyceride biosynthetic process [GO:0019432] GO:0002244; GO:0003841; GO:0005635; GO:0005739; GO:0005741; GO:0005789; GO:0006654; GO:0008654; GO:0016021; GO:0016024; GO:0019432 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. 0 0 PF16076;PF01553; Q9PRL8 CHOYP_ACBP.2.4 m.21659 sp ACBP_CHICK 71.951 82 23 0 23 104 5 86 2.82E-38 126 ACBP_CHICK reviewed Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) DBI Gallus gallus (Chicken) 86 transport [GO:0006810] GO:0000062; GO:0005783; GO:0005794; GO:0006810; GO:0008289 0 0 0 PF00887; Q9QYK7 CHOYP_RNF11.2.2 m.48161 sp RNF11_MOUSE 65 160 40 4 26 175 1 154 2.82E-66 202 RNF11_MOUSE reviewed RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669) Rnf11 N4wbp2 Sid1669 Mus musculus (Mouse) 154 protein autoubiquitination [GO:0051865]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0004842; GO:0005634; GO:0005769; GO:0006511; GO:0008270; GO:0042787; GO:0051865; GO:0055037; GO:0070062 0 0 0 PF13639; Q9QYZ9 CHOYP_PRS33.1.1 m.4196 sp PRS30_MOUSE 31.529 314 154 13 6 303 8 276 2.82E-33 127 PRS30_MOUSE reviewed Serine protease 30 (EC 3.4.21.-) (Distal intestinal serine protease) (Transmembrane serine protease 8) Prss30 Disp Tmprss8 Mus musculus (Mouse) 310 proteolysis [GO:0006508]; sodium ion transport [GO:0006814] GO:0004252; GO:0005886; GO:0006508; GO:0006814; GO:0008236; GO:0017080; GO:0031225 0 0 cd00190; PF00089; Q9UGM3 CHOYP_PRSS12.1.1 m.3344 sp DMBT1_HUMAN 54.455 101 43 2 241 339 363 462 2.82E-25 110 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9ULI1 CHOYP_LOC763845.1.1 m.35345 sp NWD2_HUMAN 24.617 914 608 21 502 1364 147 1030 2.82E-69 263 NWD2_HUMAN reviewed NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 0 0 0 0 0 PF13271; Q9ULJ7 CHOYP_LOC100641396.13.27 m.39264 sp ANR50_HUMAN 31.466 607 353 22 732 1310 531 1102 2.82E-43 176 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VXX8 CHOYP_RL371.2.2 m.56675 sp RL371_DROME 75.581 86 21 0 40 125 1 86 2.82E-42 137 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9X248 CHOYP_LOC101161976.1.1 m.43986 sp FABG_THEMA 39.676 247 139 4 27 269 3 243 2.82E-47 160 FABG_THEMA reviewed 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) (3-ketoacyl-acyl carrier protein reductase) (Beta-Ketoacyl-acyl carrier protein reductase) (Beta-ketoacyl-ACP reductase) fabG TM_1724 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) 246 fatty acid elongation [GO:0030497] GO:0004316; GO:0030497; GO:0050661; GO:0051287; GO:0102132 PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 0 Q9Y394 CHOYP_BRAFLDRAFT_216841.3.4 m.55407 sp DHRS7_HUMAN 48.986 296 148 3 27 320 29 323 2.82E-91 278 DHRS7_HUMAN reviewed Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) 339 0 GO:0016020; GO:0016491 0 0 0 PF00106; Q9Z0H0 CHOYP_LOC100367914.1.1 m.8454 sp CDC7_MOUSE 41.935 527 221 8 78 520 34 559 2.82E-121 370 CDC7_MOUSE reviewed Cell division cycle 7-related protein kinase (CDC7-related kinase) (muCdc7) (EC 2.7.11.1) Cdc7 Cdc7l1 Mus musculus (Mouse) 564 cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; peptidyl-serine phosphorylation [GO:0018105]; phagocytosis [GO:0006909]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; regulation of cell shape [GO:0008360] GO:0000727; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006270; GO:0006909; GO:0008284; GO:0008360; GO:0010571; GO:0010971; GO:0015630; GO:0016301; GO:0018105; GO:0044770; GO:0045171; GO:0046872; GO:0051301 0 0 0 PF00069; A4IF63 CHOYP_BRAFLDRAFT_87285.4.8 m.52672 sp TRIM2_BOVIN 24.837 153 110 3 533 681 589 740 2.83E-07 57.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5D8M0 CHOYP_ISCW_ISCW020529.1.1 m.14794 sp TYDP2_XENLA 40 355 187 6 13 344 19 370 2.83E-83 259 TYDP2_XENLA reviewed Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (TRAF and TNF receptor-associated protein homolog) tdp2 ttrap Xenopus laevis (African clawed frog) 371 double-strand break repair [GO:0006302] GO:0000287; GO:0003697; GO:0004518; GO:0006302; GO:0016605; GO:0030145; GO:0070260 0 0 0 PF03372; B0BLU1 CHOYP_RS3.1.7 m.3662 sp RN168_XENTR 44.271 192 93 3 1 178 7 198 2.83E-39 157 RN168_XENTR reviewed E3 ubiquitin-protein ligase RNF168 (EC 6.3.2.-) (RING finger protein 168) rnf168 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 535 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone H2A-K13 ubiquitination [GO:0036351]; histone H2A-K15 ubiquitination [GO:0036352]; histone H2A K63-linked ubiquitination [GO:0070535]; histone H2A monoubiquitination [GO:0035518]; isotype switching [GO:0045190]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0003682; GO:0004842; GO:0005634; GO:0006302; GO:0006511; GO:0006974; GO:0008270; GO:0010212; GO:0016567; GO:0016874; GO:0034244; GO:0035518; GO:0035861; GO:0036351; GO:0036352; GO:0042393; GO:0043130; GO:0045190; GO:0045739; GO:0070530; GO:0070534; GO:0070535 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00097; E1BD59 CHOYP_TRIM56.1.2 m.24652 sp TRI56_BOVIN 27.073 410 262 10 16 399 56 454 2.83E-34 139 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O15992 CHOYP_MONBRDRAFT_34875.1.1 m.20826 sp KARG_ANTJA 48.563 348 161 7 44 385 377 712 2.83E-100 316 KARG_ANTJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Anthopleura japonica (Sea anemone) 715 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O70279 CHOYP_BRAFLDRAFT_164902.1.1 m.25687 sp DGC14_MOUSE 44.301 465 226 13 26 480 38 479 2.83E-113 345 DGC14_MOUSE reviewed Protein DGCR14 (DiGeorge syndrome critical region 14 homolog) (ES2 protein) (Expressed sequence 2 embryonic lethal) Dgcr14 Dgsi Es2 Es2el Mus musculus (Mouse) 479 mRNA processing [GO:0006397]; nervous system development [GO:0007399]; RNA splicing [GO:0008380] GO:0005634; GO:0006397; GO:0007399; GO:0008380; GO:0071013 0 0 0 PF09751; P05186 CHOYP_PPBT.3.4 m.27614 sp PPBT_HUMAN 50 504 231 9 14 501 7 505 2.83E-164 479 PPBT_HUMAN reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Homo sapiens (Human) 524 cellular response to organic cyclic compound [GO:0071407]; cementum mineralization [GO:0071529]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; osteoblast differentiation [GO:0001649]; response to antibiotic [GO:0046677]; response to glucocorticoid [GO:0051384]; response to lipopolysaccharide [GO:0032496]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501] GO:0001501; GO:0001649; GO:0001958; GO:0003006; GO:0004035; GO:0005578; GO:0005615; GO:0005886; GO:0016020; GO:0016021; GO:0016462; GO:0031225; GO:0032496; GO:0033280; GO:0046677; GO:0046872; GO:0051384; GO:0065010; GO:0070062; GO:0071407; GO:0071529 0 0 0 PF00245; P06867 CHOYP_PLMN.4.11 m.29150 sp PLMN_PIG 37.422 481 212 20 695 1115 108 559 2.83E-74 266 PLMN_PIG reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Sus scrofa (Pig) 809 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P15146 CHOYP_LOC100711676.1.1 m.24364 sp MTAP2_RAT 51.923 156 66 3 638 784 1652 1807 2.83E-37 155 MTAP2_RAT reviewed Microtubule-associated protein 2 (MAP-2) Map2 Mtap2 Rattus norvegicus (Rat) 1861 central nervous system neuron development [GO:0021954]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570] GO:0000226; GO:0001578; GO:0005790; GO:0005791; GO:0005874; GO:0005875; GO:0008017; GO:0021954; GO:0030425; GO:0031175; GO:0032355; GO:0032570; GO:0043005; GO:0043025; GO:0043234 0 0 0 PF08377;PF00418; P24668 CHOYP_NEMVEDRAFT_V1G238307.1.1 m.28471 sp MPRD_MOUSE 36.937 111 64 3 124 228 136 246 2.83E-12 68.2 MPRD_MOUSE reviewed Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6pr 46mpr Mus musculus (Mouse) 278 intracellular protein transport [GO:0006886]; secretion of lysosomal enzymes [GO:0033299] GO:0005537; GO:0005765; GO:0005768; GO:0005770; GO:0005802; GO:0006886; GO:0015578; GO:0016020; GO:0016021; GO:0033299; GO:0048471 0 0 0 PF02157; P35858 CHOYP_LOC100892941.1.1 m.12612 sp ALS_HUMAN 28.028 578 348 4 144 704 77 603 2.83E-56 209 ALS_HUMAN reviewed Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Homo sapiens (Human) 605 cell adhesion [GO:0007155]; cellular protein metabolic process [GO:0044267]; signal transduction [GO:0007165] GO:0005520; GO:0005576; GO:0005615; GO:0005654; GO:0007155; GO:0007165; GO:0042567; GO:0044267; GO:0070062 0 0 0 PF13855;PF01462; P82931 CHOYP_RT06.1.1 m.1897 sp RT06_BOVIN 34.513 113 66 3 1 112 1 106 2.83E-15 72 RT06_BOVIN reviewed "28S ribosomal protein S6, mitochondrial (MRP-S6) (S6mt)" MRPS6 RPMS6 Bos taurus (Bovine) 124 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005763; GO:0032543; GO:0070124; GO:0070125; GO:0070181 0 0 0 PF01250; Q02290 CHOYP_contig_042082 m.48338 sp XYNB_NEOPA 25.217 230 163 6 75 295 390 619 2.83E-15 80.9 XYNB_NEOPA reviewed "Endo-1,4-beta-xylanase B (Xylanase B) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase B)" xynB Neocallimastix patriciarum (Rumen fungus) 860 xylan catabolic process [GO:0045493] GO:0005576; GO:0030248; GO:0031176; GO:0045493 PATHWAY: Glycan degradation; xylan degradation. 0 0 PF00734;PF00331; Q0P4F7 CHOYP_ACSF2.2.4 m.30204 sp ACSF2_DANRE 27.74 584 360 18 5 558 53 604 2.83E-46 174 ACSF2_DANRE reviewed "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) 606 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005739; GO:0006631; GO:0016874 0 0 0 PF00501;PF13193; Q0VAA2 CHOYP_LOC100187037.1.1 m.55673 sp LR74A_HUMAN 33.028 436 271 6 161 593 66 483 2.83E-67 231 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q10S72 CHOYP_contig_042076 m.48327 sp 4CLL4_ORYSJ 27.616 344 221 11 101 431 195 523 2.83E-28 121 4CLL4_ORYSJ reviewed 4-coumarate--CoA ligase-like 4 (EC 6.2.1.-) 4CLL4 Os03g0132000 LOC_Os03g04000 OsJ_09299 Oryza sativa subsp. japonica (Rice) 552 metabolic process [GO:0008152] GO:0005524; GO:0008152; GO:0016874 0 0 0 PF00501;PF13193; Q12955 CHOYP_TVAG_313830.3.4 m.40014 sp ANK3_HUMAN 31.429 350 219 7 7 353 469 800 2.83E-35 141 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q16TM5 CHOYP_LOC590235.1.1 m.49618 sp BND7A_AEDAE 80.412 97 19 0 3 99 189 285 2.83E-42 142 BND7A_AEDAE reviewed Band 7 protein AAEL010189 AAEL010189 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 297 0 GO:0016021 0 0 0 PF01145; Q26636 CHOYP_LOC100197138.1.1 m.52180 sp CATL_SARPE 63.687 179 65 0 28 206 160 338 2.83E-83 253 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q3T042 CHOYP_LOC575793.1.2 m.34690 sp NOB1_BOVIN 48.052 231 101 4 272 484 178 407 2.83E-65 220 NOB1_BOVIN reviewed RNA-binding protein NOB1 NOB1 Bos taurus (Bovine) 413 cleavage involved in rRNA processing [GO:0000469]; maturation of SSU-rRNA [GO:0030490] GO:0000469; GO:0004521; GO:0005634; GO:0030490; GO:0030688; GO:0046872 0 0 0 PF08772;PF17146;PF15017; Q5BIM1 CHOYP_LOC100374741.59.83 m.53299 sp TRI45_BOVIN 30.556 144 77 7 10 131 135 277 2.83E-07 56.6 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5F339 CHOYP_CCHL.2.2 m.66608 sp CCHL_CHICK 60.289 277 85 6 3 261 2 271 2.83E-110 322 CCHL_CHICK reviewed Cytochrome c-type heme lyase (CCHL) (EC 4.4.1.17) (Holocytochrome c-type synthase) HCCS RCJMB04_37l21 Gallus gallus (Chicken) 273 0 GO:0004408; GO:0005743; GO:0046872 0 0 0 PF01265; Q5R630 CHOYP_BRAFLDRAFT_72035.1.1 m.48832 sp NECP1_PONAB 55.088 285 104 6 25 300 6 275 2.83E-98 293 NECP1_PONAB reviewed Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) NECAP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 275 endocytosis [GO:0006897]; protein transport [GO:0015031] GO:0005886; GO:0006897; GO:0015031; GO:0030665 0 0 cd13228; PF07933; Q5RBR8 CHOYP_EIF4H.1.3 m.2169 sp IF4H_PONAB 64.286 126 41 2 20 143 29 152 2.83E-42 144 IF4H_PONAB reviewed Eukaryotic translation initiation factor 4H (eIF-4H) EIF4H Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 228 0 GO:0000166; GO:0003743; GO:0048471 0 0 0 PF00076; Q5RJ80 CHOYP_LOC101066767.1.2 m.5406 sp CAPR2_DANRE 32.031 128 84 3 238 363 785 911 2.83E-11 68.6 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5U5C5 CHOYP_PRP31.5.6 m.50383 sp PRP31_XENLA 71.585 183 52 0 1 183 307 489 2.83E-76 241 PRP31_XENLA reviewed U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Xenopus laevis (African clawed frog) 498 spliceosomal tri-snRNP complex assembly [GO:0000244] GO:0000244; GO:0003723; GO:0005681; GO:0046540; GO:0071339 0 0 0 PF01798;PF09785; Q5XIS2 CHOYP_DSIM_GD25210.1.1 m.29275 sp CPTP_RAT 35.714 210 128 2 41 243 7 216 2.83E-43 148 CPTP_RAT reviewed Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP) Cptp Gltpd1 Rattus norvegicus (Rat) 216 ceramide 1-phosphate transport [GO:1902389] GO:0005543; GO:0005548; GO:0005640; GO:0005730; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0017089; GO:0051861; GO:1902387; GO:1902388; GO:1902389 0 0 0 PF08718; Q63505 CHOYP_LOC100875552.1.1 m.6469 sp TF3C1_RAT 28.443 1002 598 29 529 1435 610 1587 2.83E-85 316 TF3C1_RAT reviewed General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha) Gtf3c1 Rattus norvegicus (Rat) 2148 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351 0 0 0 PF04182; Q66IC8 CHOYP_LOC100371143.1.1 m.27046 sp TC1D1_DANRE 33.333 165 106 3 19 183 13 173 2.83E-27 103 TC1D1_DANRE reviewed Tctex1 domain-containing protein 1 tctex1d1 zgc:101774 Danio rerio (Zebrafish) (Brachydanio rerio) 173 0 0 0 0 0 PF03645; Q6AYR9 CHOYP_TSN18.1.1 m.14981 sp TSN1_RAT 25.475 263 165 7 6 263 3 239 2.83E-11 65.1 TSN1_RAT reviewed Tetraspanin-1 (Tspan-1) Tspan1 Rattus norvegicus (Rat) 241 cell migration [GO:0016477]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of endocytosis [GO:0045807]; protein stabilization [GO:0050821] GO:0005765; GO:0005887; GO:0007166; GO:0008283; GO:0016477; GO:0045807; GO:0048471; GO:0050821; GO:0070062 0 0 0 PF00335; Q6NRX3 CHOYP_ZNF710.2.2 m.40759 sp ADIPB_XENLA 38.843 121 56 2 147 249 401 521 2.83E-14 77 ADIPB_XENLA reviewed Afadin- and alpha-actinin-binding protein B (ADIP-B) (Afadin DIL domain-interacting protein B) (SSX2-interacting protein B) ssx2ip-b ssx2ip Xenopus laevis (African clawed frog) 545 cell adhesion [GO:0007155]; centrosome organization [GO:0051297] GO:0005874; GO:0005912; GO:0007155; GO:0034451; GO:0051011; GO:0051297 0 0 0 PF11559; Q8BN57 CHOYP_LOC100699161.1.1 m.35140 sp CC033_MOUSE 25.359 209 149 5 6 210 16 221 2.83E-15 76.6 CC033_MOUSE reviewed Protein C3orf33 homolog 0 Mus musculus (Mouse) 294 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; regulation of MAPK cascade [GO:0043408]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090] GO:0005615; GO:0016021; GO:0043408; GO:0051090; GO:0070373 0 0 0 0 Q8N2G6 CHOYP_LOC100746981.1.1 m.48823 sp ZCH24_HUMAN 53.909 243 90 7 31 259 6 240 2.83E-78 239 ZCH24_HUMAN reviewed Zinc finger CCHC domain-containing protein 24 ZCCHC24 C10orf56 Homo sapiens (Human) 241 0 GO:0008270; GO:0044822 0 0 0 PF17180;PF13696; Q8N556 CHOYP_BRAFLDRAFT_118464.1.1 m.62863 sp AFAP1_HUMAN 28.814 118 79 3 587 703 352 465 2.83E-08 61.6 AFAP1_HUMAN reviewed Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110) AFAP1 AFAP Homo sapiens (Human) 730 regulation of cytoskeleton organization [GO:0051493]; regulation of signal transduction [GO:0009966] GO:0005737; GO:0005856; GO:0005925; GO:0009966; GO:0051493 0 0 0 PF00169; Q91XF0 CHOYP_LOC100701105.1.1 m.56657 sp PNPO_MOUSE 51.948 231 108 2 26 255 33 261 2.83E-88 265 PNPO_MOUSE reviewed Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) Pnpo Mus musculus (Mouse) 261 mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; pyridoxal phosphate biosynthetic process [GO:0042823]; pyridoxine biosynthetic process [GO:0008615]; xenophagy [GO:0098792] GO:0002230; GO:0004733; GO:0005654; GO:0005737; GO:0008615; GO:0010181; GO:0042823; GO:0070062; GO:0098779; GO:0098792 PATHWAY: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.; PATHWAY: Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1. 0 0 PF10590;PF01243; Q91ZY8 CHOYP_TRIM40.1.1 m.37561 sp TRIM9_RAT 30.508 118 56 7 10 107 165 276 2.83E-06 52.8 TRIM9_RAT reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (SNAP-25-interacting RING finger protein) (Tripartite motif-containing protein 9) Trim9 Spring Rattus norvegicus (Rat) 710 negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of SNARE complex assembly [GO:0035544]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; synaptic vesicle exocytosis [GO:0016079] GO:0000149; GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016079; GO:0016874; GO:0030054; GO:0030425; GO:0035544; GO:0043161; GO:0045955 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643; Q96PE2 CHOYP_LOC658611.1.1 m.11239 sp ARHGH_HUMAN 46.847 333 168 4 1290 1617 1735 2063 2.83E-87 320 ARHGH_HUMAN reviewed Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4) ARHGEF17 KIAA0337 TEM4 Homo sapiens (Human) 2063 actin cytoskeleton organization [GO:0030036]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005085; GO:0005089; GO:0005829; GO:0030036; GO:0035023; GO:0043065; GO:0051056 0 0 0 PF00621; Q9BXM0 CHOYP_contig_039831 m.45008 sp PRAX_HUMAN 23.897 272 190 6 6 271 508 768 2.83E-11 67.4 PRAX_HUMAN reviewed Periaxin PRX KIAA1620 Homo sapiens (Human) 1461 axon ensheathment [GO:0008366]; nerve development [GO:0021675] GO:0005634; GO:0005737; GO:0005886; GO:0008366; GO:0021675; GO:0030054; GO:0043209 0 0 0 0 Q9D0S4 CHOYP_LOC100749690.1.2 m.7466 sp NEUL2_MOUSE 41.007 278 132 10 2 263 24 285 2.83E-58 190 NEUL2_MOUSE reviewed Neuralized-like protein 2 Neurl2 Ozz Mus musculus (Mouse) 285 intracellular signal transduction [GO:0035556]; myofibril assembly [GO:0030239]; protein ubiquitination [GO:0016567]; sarcomere organization [GO:0045214] GO:0005927; GO:0016567; GO:0030239; GO:0030891; GO:0035556; GO:0045214 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07177;PF07525; Q9DC61 CHOYP_MPPA.2.2 m.18272 sp MPPA_MOUSE 53.58 433 196 2 2 434 83 510 2.83E-162 470 MPPA_MOUSE reviewed Mitochondrial-processing peptidase subunit alpha (EC 3.4.24.64) (Alpha-MPP) (P-55) Pmpca Inpp5e Mus musculus (Mouse) 524 protein processing involved in protein targeting to mitochondrion [GO:0006627] GO:0004222; GO:0005615; GO:0005739; GO:0005743; GO:0005759; GO:0006627; GO:0008270 0 0 0 PF00675;PF05193; Q9H2B2 CHOYP_SYT4.1.1 m.62593 sp SYT4_HUMAN 44.258 418 207 11 20 422 16 422 2.83E-106 323 SYT4_HUMAN reviewed Synaptotagmin-4 (Synaptotagmin IV) (SytIV) SYT4 KIAA1342 Homo sapiens (Human) 425 brain development [GO:0007420]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; negative regulation of vesicle fusion [GO:0031339]; positive regulation of dendrite extension [GO:1903861]; vesicle fusion [GO:0006906] GO:0001786; GO:0005886; GO:0006906; GO:0007420; GO:0016021; GO:0019905; GO:0030054; GO:0030276; GO:0030672; GO:0031045; GO:0031339; GO:0043005; GO:0043231; GO:0046872; GO:0048471; GO:0048791; GO:1903861 0 0 0 PF00168; Q9Z336 CHOYP_LOC100370790.1.1 m.9845 sp DYLT1_RAT 85.841 113 16 0 1 113 1 113 2.83E-70 208 DYLT1_RAT reviewed Dynein light chain Tctex-type 1 (Activator of G-protein signaling 2) (AGS2) (T-complex testis-specific protein 1 homolog) Dynlt1 Tctel1 Tctex-1 Tctex1 Rattus norvegicus (Rat) 113 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; intracellular protein transport [GO:0006886]; intracellular transport of viral protein in host cell [GO:0019060]; mitotic nuclear division [GO:0007067]; negative regulation of neurogenesis [GO:0050768]; neuron projection morphogenesis [GO:0048812]; regulation of cytoskeleton organization [GO:0051493]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; regulation of GTPase activity [GO:0043087] GO:0000132; GO:0003774; GO:0005794; GO:0005819; GO:0005868; GO:0005874; GO:0006886; GO:0007067; GO:0008277; GO:0019060; GO:0043087; GO:0043657; GO:0048812; GO:0050768; GO:0051301; GO:0051493 0 0 0 PF03645; A4IF63 CHOYP_BRAFLDRAFT_69764.8.19 m.32691 sp TRIM2_BOVIN 26.291 213 125 7 200 396 492 688 2.84E-10 65.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E7F568 CHOYP_LOC100487213.3.4 m.57977 sp COBL_DANRE 26.957 230 141 6 55 280 59 265 2.84E-14 81.6 COBL_DANRE reviewed Protein cordon-bleu cobl Danio rerio (Zebrafish) (Brachydanio rerio) 1343 actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; auditory receptor cell stereocilium organization [GO:0060088]; cilium morphogenesis [GO:0060271]; heart jogging [GO:0003146]; heart looping [GO:0001947] GO:0001726; GO:0001947; GO:0003146; GO:0003785; GO:0005829; GO:0005856; GO:0005886; GO:0030041; GO:0051639; GO:0060088; GO:0060271 0 0 0 PF09469;PF02205; P04323 CHOYP_LOC100535270.2.4 m.9251 sp POL3_DROME 41.099 455 239 10 4 448 193 628 2.84E-99 327 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P08004 CHOYP_LOC100907845.2.3 m.23111 sp CHS1_YEAST 25.845 414 244 15 890 1251 570 972 2.84E-19 99 CHS1_YEAST reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) CHS1 YNL192W N1404 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1131 cell separation after cytokinesis [GO:0000920]; cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0000920; GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0045009; GO:0071555 0 0 0 PF01644;PF08407; P14314 CHOYP_PRKCSH.1.1 m.28109 sp GLU2B_HUMAN 40.323 496 255 4 39 495 14 507 2.84E-125 380 GLU2B_HUMAN reviewed Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) PRKCSH G19P1 Homo sapiens (Human) 528 intracellular signal transduction [GO:0035556]; N-glycan processing [GO:0006491]; protein folding [GO:0006457] GO:0005080; GO:0005509; GO:0005622; GO:0005783; GO:0005788; GO:0006457; GO:0006491; GO:0035556; GO:0044325; GO:0051219 PATHWAY: Glycan metabolism; N-glycan metabolism. 0 0 PF13202;PF12999;PF13015; P30884 CHOYP_BMP4.1.2 m.17479 sp BMP2B_XENLA 29.508 183 108 9 141 312 226 398 2.84E-12 70.1 BMP2B_XENLA reviewed Bone morphogenetic protein 2-B (BMP-2-II) bmp2-b Xenopus laevis (African clawed frog) 398 cartilage development [GO:0051216]; cell differentiation [GO:0030154]; growth [GO:0040007]; ossification [GO:0001503] GO:0001503; GO:0005615; GO:0030154; GO:0040007; GO:0051216 0 0 0 PF00019;PF00688; P49907 CHOYP_LOC100304446.1.2 m.23047 sp SEPP1_BOVIN 32.759 116 72 4 1 110 61 176 2.84E-11 63.9 SEPP1_BOVIN reviewed Selenoprotein P (SeP) (Selenoprotein P-like protein) SEPP1 SELP Bos taurus (Bovine) 402 0 GO:0005576 0 0 0 PF04593;PF04592; P98187 CHOYP_CAOG_02976.1.2 m.41291 sp CP4F8_HUMAN 29.245 424 266 10 122 517 101 518 2.84E-46 172 CP4F8_HUMAN reviewed Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016021; GO:0018685; GO:0019825; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q06852 CHOYP_LOC100535301.4.5 m.41861 sp SLAP1_CLOTH 52.529 257 78 18 1 221 1471 1719 2.84E-14 80.9 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q14790 CHOYP_CASPA.1.1 m.24484 sp CASP8_HUMAN 28.22 528 306 16 14 525 7 477 2.84E-50 182 CASP8_HUMAN reviewed Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] CASP8 MCH5 Homo sapiens (Human) 479 activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cell surface receptor signaling pathway [GO:0007166]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; death-inducing signaling complex assembly [GO:0071550]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; macrophage differentiation [GO:0030225]; natural killer cell activation [GO:0030101]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of proteolysis [GO:0045862]; protein heterooligomerization [GO:0051291]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of necrotic cell death [GO:0010939]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to cold [GO:0009409]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process [GO:0039650]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell activation [GO:0042110]; TRAIL-activated apoptotic signaling pathway [GO:0036462]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] GO:0004197; GO:0005654; GO:0005737; GO:0005739; GO:0005741; GO:0005815; GO:0005829; GO:0005856; GO:0006508; GO:0006915; GO:0006919; GO:0006921; GO:0007166; GO:0008233; GO:0008234; GO:0009409; GO:0010803; GO:0010939; GO:0030101; GO:0030225; GO:0031264; GO:0031265; GO:0031625; GO:0032025; GO:0032355; GO:0032496; GO:0034612; GO:0035666; GO:0035877; GO:0036462; GO:0039650; GO:0042110; GO:0042113; GO:0042802; GO:0043005; GO:0043123; GO:0043124; GO:0044297; GO:0045121; GO:0045471; GO:0045651; GO:0045862; GO:0046677; GO:0051291; GO:0051603; GO:0060715; GO:0070423; GO:0071260; GO:0071407; GO:0071550; GO:0097110; GO:0097153; GO:0097190; GO:0097191; GO:0097194; GO:0097199; GO:0097202; GO:0097296; GO:0097342; GO:1900740; GO:1902041; GO:1902042 0 0 0 PF01335; Q1PSW8 CHOYP_BRAFLDRAFT_87327.2.13 m.23913 sp LIN41_MOUSE 27.465 142 87 4 87 216 697 834 2.84E-06 52 LIN41_MOUSE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to organic substance [GO:0071310]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of protein metabolic process [GO:0051246]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0017148; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051246; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0071310; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q24372 CHOYP_OBCAM.1.1 m.32050 sp LACH_DROME 27.488 211 127 8 60 262 79 271 2.84E-14 76.3 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q2YGT9 CHOYP_BRAFLDRAFT_114734.3.8 m.15141 sp RL6_PIG 58.491 106 41 1 5 110 182 284 2.84E-33 119 RL6_PIG reviewed 60S ribosomal protein L6 RPL6 Sus scrofa (Pig) 284 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; Q460N5 CHOYP_PARP14.20.22 m.60233 sp PAR14_HUMAN 34.545 165 103 3 357 517 1027 1190 2.84E-18 93.6 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q54AX6 CHOYP_LOC100367326.1.1 m.56732 sp CLCA_DICDI 32.651 830 449 19 127 894 82 863 2.84E-119 387 CLCA_DICDI reviewed Chloride channel protein A clcA DDB_G0294096 Dictyostelium discoideum (Slime mold) 863 0 GO:0005247; GO:0034707 0 0 0 PF00571;PF00654; Q566C8 CHOYP_ANR54.2.2 m.30660 sp ANR54_RAT 62.195 82 31 0 105 186 104 185 2.84E-28 110 ANR54_RAT reviewed Ankyrin repeat domain-containing protein 54 Ankrd54 Rattus norvegicus (Rat) 299 positive regulation of erythrocyte differentiation [GO:0045648]; regulation of intracellular signal transduction [GO:1902531] GO:0005634; GO:0005737; GO:0030496; GO:0045648; GO:1902531 0 0 0 0 Q5ND28 CHOYP_SCARF1.3.7 m.28859 sp SREC_MOUSE 40.952 105 56 4 187 289 214 314 2.84E-13 75.1 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q60980 CHOYP_LOC660309.2.2 m.61683 sp KLF3_MOUSE 82.418 91 16 0 123 213 251 341 2.84E-52 174 KLF3_MOUSE reviewed Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) Klf3 Bklf Mus musculus (Mouse) 344 "cellular response to peptide [GO:1901653]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872; GO:1901653 0 0 0 PF00096; Q66JY6 CHOYP_LOC100878599.1.1 m.11080 sp ARG39_MOUSE 34.32 338 205 7 36 366 14 341 2.84E-43 161 ARG39_MOUSE reviewed Rho guanine nucleotide exchange factor 39 Arhgef39 Mus musculus (Mouse) 344 positive regulation of cell migration [GO:0030335]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005886; GO:0030335; GO:0035023 0 0 0 PF00621; Q6AXK4 CHOYP_LOC100373186.1.1 m.58981 sp BABA1_DANRE 40.26 231 131 5 71 296 129 357 2.84E-56 189 BABA1_DANRE reviewed BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) babam1 merit40 nba1 Zgc:100909 Danio rerio (Zebrafish) (Brachydanio rerio) 370 cell division [GO:0051301]; covalent chromatin modification [GO:0016569]; double-strand break repair [GO:0006302]; G2 DNA damage checkpoint [GO:0031572]; mitotic nuclear division [GO:0007067]; positive regulation of DNA repair [GO:0045739]; protein K63-linked deubiquitination [GO:0070536]; response to ionizing radiation [GO:0010212] GO:0005634; GO:0005737; GO:0006302; GO:0007067; GO:0010212; GO:0016569; GO:0031572; GO:0045739; GO:0051301; GO:0070531; GO:0070536; GO:0070552 0 0 0 0 Q6IRN2 CHOYP_HOW.1.5 m.1237 sp QKIB_XENLA 55.09 334 136 6 3 328 5 332 2.84E-117 345 QKIB_XENLA reviewed Protein quaking-B qki-b Xenopus laevis (African clawed frog) 342 cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism development [GO:0007275]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380] GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0006417; GO:0007275; GO:0008380; GO:0030154; GO:0051028 0 0 0 PF00013;PF16551;PF16544; Q6PFY8 CHOYP_BRAFLDRAFT_88217.11.14 m.53365 sp TRI45_MOUSE 24.549 277 188 12 4 265 127 397 2.84E-09 62 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PFY8 CHOYP_LOC100373444.63.79 m.59147 sp TRI45_MOUSE 26.012 173 112 7 5 170 129 292 2.84E-06 52.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PFY8 CHOYP_TRI46.3.3 m.64791 sp TRI45_MOUSE 29.064 203 130 5 13 206 127 324 2.84E-13 73.9 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6UPE0 CHOYP_LOC100651467.1.2 m.8880 sp CHDH_RAT 35.49 572 312 13 73 627 46 577 2.84E-88 290 CHDH_RAT reviewed "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) 599 glycine betaine biosynthetic process from choline [GO:0019285] GO:0005743; GO:0008812; GO:0019285; GO:0050660 PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. 0 0 PF05199;PF00732; Q6ZRF8 CHOYP_LOC100374974.8.16 m.32642 sp RN207_HUMAN 19.792 192 141 5 1 190 114 294 2.84E-08 59.3 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7Z5L3 CHOYP_C1QL4.10.10 m.66986 sp C1QL2_HUMAN 33.077 130 82 3 61 187 157 284 2.84E-12 66.6 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q86UT8 CHOYP_LOC101168960.1.1 m.7703 sp CCD84_HUMAN 35.152 330 192 7 24 338 5 327 2.84E-44 163 CCD84_HUMAN reviewed Coiled-coil domain-containing protein 84 CCDC84 DLNB14 Homo sapiens (Human) 332 0 0 0 0 0 PF14968; Q8BMU0 CHOYP_ZNF76.1.1 m.8685 sp ZNF76_MOUSE 54.47 481 160 11 100 563 1 439 2.84E-169 500 ZNF76_MOUSE reviewed Zinc finger protein 76 (Zinc finger protein 523) Znf76 Zfp523 Mus musculus (Mouse) 568 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q8CGE9 CHOYP_RGS12B.1.1 m.53632 sp RGS12_MOUSE 33.563 581 314 17 852 1388 708 1260 2.84E-75 280 RGS12_MOUSE reviewed Regulator of G-protein signaling 12 (RGS12) Rgs12 Mus musculus (Mouse) 1381 termination of G-protein coupled receptor signaling pathway [GO:0038032] GO:0005057; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0030054; GO:0030425; GO:0030695; GO:0038032; GO:0043025; GO:0043234; GO:0045202; GO:0097440 0 0 0 PF02188;PF00595;PF02196;PF00615; Q8IZR5 CHOYP_LOC100368692.2.2 m.48945 sp CKLF4_HUMAN 30.058 173 111 5 2 168 24 192 2.84E-12 66.2 CKLF4_HUMAN reviewed CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4) CMTM4 CKLFSF4 Homo sapiens (Human) 234 chemotaxis [GO:0006935] GO:0005615; GO:0006935; GO:0016021 0 0 0 PF01284; Q8JHV9 CHOYP_BIRC7.1.5 m.3111 sp BIR7A_XENLA 27.715 267 169 6 78 324 139 401 2.84E-33 129 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8JHZ8 CHOYP_NEMVEDRAFT_V1G51544.1.1 m.25521 sp PALD_CHICK 33.333 126 78 3 5 129 574 694 2.84E-10 60.8 PALD_CHICK reviewed Paladin PALD1 PALD RCJMB04_11g7 Gallus gallus (Chicken) 868 0 GO:0004725; GO:0005634; GO:0005737; GO:0005829 0 0 0 0 Q8N2E2 CHOYP_LOC100376067.3.3 m.62991 sp VWDE_HUMAN 32.993 294 151 14 218 503 1331 1586 2.84E-17 90.1 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8QFR2 CHOYP_LOC100556463.1.1 m.25818 sp HIRA_XENLA 40.566 212 122 4 15 224 677 886 2.84E-47 171 HIRA_XENLA reviewed Protein HIRA hira hira-a Xenopus laevis (African clawed frog) 1013 "chromatin modification [GO:0016568]; covalent chromatin modification [GO:0016569]; DNA replication-independent nucleosome assembly [GO:0006336]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006336; GO:0006351; GO:0006355; GO:0016568; GO:0016569 0 0 0 PF07569;PF09453;PF00400; Q8TCU4 CHOYP_DPSE_GA28568.3.9 m.19206 sp ALMS1_HUMAN 25.806 217 119 4 2604 2817 3983 4160 2.84E-14 83.6 ALMS1_HUMAN reviewed Alstrom syndrome protein 1 ALMS1 KIAA0328 Homo sapiens (Human) 4167 endosomal transport [GO:0016197]; G2/M transition of mitotic cell cycle [GO:0000086]; regulation of stress fiber assembly [GO:0051492] GO:0000086; GO:0000922; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0005929; GO:0016197; GO:0051492 0 0 0 PF15309; Q8VHS2 CHOYP_LOC100376421.4.4 m.57359 sp CRUM1_MOUSE 40.476 84 34 3 572 653 155 224 2.84E-08 61.2 CRUM1_MOUSE reviewed Protein crumbs homolog 1 Crb1 Mus musculus (Mouse) 1405 eye photoreceptor cell development [GO:0042462]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009] GO:0005509; GO:0005886; GO:0005902; GO:0007009; GO:0016021; GO:0042462; GO:0061024 0 0 0 PF00008;PF12661;PF02210; Q96BZ8 CHOYP_LOC100375896.2.2 m.54014 sp LENG1_HUMAN 39.55 311 133 11 1 303 1 264 2.84E-45 157 LENG1_HUMAN reviewed Leukocyte receptor cluster member 1 LENG1 Homo sapiens (Human) 264 0 0 0 0 0 PF10197; Q96MM6 CHOYP_BRAFLDRAFT_208436.30.32 m.61782 sp HS12B_HUMAN 35.229 633 335 17 73 640 64 686 2.84E-119 373 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q98943 CHOYP_CASP2.3.5 m.17601 sp CASP2_CHICK 34.483 87 57 0 131 217 7 93 2.84E-06 53.1 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q99M80 CHOYP_PTN11.2.4 m.37359 sp PTPRT_MOUSE 34.743 331 146 10 367 643 755 1069 2.84E-42 168 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9EP82 CHOYP_LOC101063181.1.1 m.12864 sp WDR4_MOUSE 36.62 355 197 8 45 387 45 383 2.84E-57 196 WDR4_MOUSE reviewed tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (WD repeat-containing protein 4) Wdr4 Mus musculus (Mouse) 413 RNA (guanine-N7)-methylation [GO:0036265]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400] GO:0005634; GO:0005654; GO:0005737; GO:0006400; GO:0030488; GO:0036265 PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03056}. 0 0 PF00400; Q9NLA3 CHOYP_LOC100215712.2.2 m.66966 sp ANO39_PATPE 43.548 62 35 0 1 62 57 118 2.84E-10 61.2 ANO39_PATPE reviewed Nucleoplasmin-like protein ANO39 (39 kDa oocyte-expressed nucleolar protein) (Nucleic acid-associated protein 36) (Nucleic acid-binding nuclear protein) (NAAP) (NAAP1) (NAAP2) 0 Patiria pectinifera (Starfish) (Asterina pectinifera) 346 mitotic nuclear division [GO:0007067]; oocyte maturation [GO:0001556] GO:0001556; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007067 0 0 0 PF16276;PF03066; Q9ULJ7 CHOYP_LOC755521.5.28 m.32618 sp ANR50_HUMAN 32.198 646 365 24 722 1336 500 1103 2.84E-58 225 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A4IF63 CHOYP_BRAFLDRAFT_124722.2.3 m.32512 sp TRIM2_BOVIN 23.913 230 128 5 74 281 490 694 2.85E-13 73.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B0UZC8 CHOYP_COX1.1.15 m.3193 sp VWC2L_DANRE 36.458 96 58 3 30 124 112 205 2.85E-10 59.3 VWC2L_DANRE reviewed von Willebrand factor C domain-containing protein 2-like vwc2l si:ch211-207d8.1 Danio rerio (Zebrafish) (Brachydanio rerio) 223 nervous system development [GO:0007399] GO:0005576; GO:0007399; GO:0030054; GO:0045202 0 0 0 PF00093; B2RXS4 CHOYP_PLXB2.1.2 m.799 sp PLXB2_MOUSE 21.992 482 288 26 42 480 34 470 2.85E-06 53.9 PLXB2_MOUSE reviewed Plexin-B2 Plxnb2 Mus musculus (Mouse) 1842 brain development [GO:0007420]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0001843; GO:0001932; GO:0002116; GO:0005887; GO:0007162; GO:0007405; GO:0007420; GO:0008360; GO:0009986; GO:0017154; GO:0043087; GO:0050772; GO:0070062; GO:0071526; GO:1902287; GO:2001222 0 0 0 PF08337;PF01437;PF01403;PF01833; B3EWZ3 CHOYP_LOC100210677.1.8 m.2859 sp CADN_ACRMI 42.494 433 236 5 299 722 143 571 2.85E-96 331 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; B4U7S7 CHOYP_LOC100678100.1.1 m.14602 sp Y501_HYDS0 29.675 246 161 5 72 312 1 239 2.85E-26 107 Y501_HYDS0 reviewed Probable transcriptional regulatory protein HY04AAS1_0501 HY04AAS1_0501 Hydrogenobaculum sp. (strain Y04AAS1) 249 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005737; GO:0006351; GO:0006355 0 0 0 PF01709; D2GXS7 CHOYP_BRAFLDRAFT_77992.2.3 m.40293 sp TRIM2_AILME 28.378 148 78 5 15 147 22 156 2.85E-13 70.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E7F568 CHOYP_LOC100487213.4.4 m.58639 sp COBL_DANRE 26.957 230 141 6 68 293 59 265 2.85E-14 82 COBL_DANRE reviewed Protein cordon-bleu cobl Danio rerio (Zebrafish) (Brachydanio rerio) 1343 actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; auditory receptor cell stereocilium organization [GO:0060088]; cilium morphogenesis [GO:0060271]; heart jogging [GO:0003146]; heart looping [GO:0001947] GO:0001726; GO:0001947; GO:0003146; GO:0003785; GO:0005829; GO:0005856; GO:0005886; GO:0030041; GO:0051639; GO:0060088; GO:0060271 0 0 0 PF09469;PF02205; O01761 CHOYP_LOC576983.1.1 m.8601 sp UNC89_CAEEL 29.542 677 429 14 360 1016 6275 6923 2.85E-72 273 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O14522 CHOYP_PTPRT.12.45 m.39573 sp PTPRT_HUMAN 28.627 765 475 21 371 1078 690 1440 2.85E-79 288 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O81884 CHOYP_BRAFLDRAFT_67662.1.1 m.3006 sp GALDH_ARATH 45.659 311 157 7 6 311 9 312 2.85E-91 278 GALDH_ARATH reviewed L-galactose dehydrogenase (At-GalDH) (L-GalDH) (EC 1.1.1.316) LGALDH At4g33670 T16L1.160 Arabidopsis thaliana (Mouse-ear cress) 319 galactose metabolic process [GO:0006012]; L-ascorbic acid biosynthetic process [GO:0019853] GO:0005829; GO:0006012; GO:0010349; GO:0019853 0 0 cd06660; PF00248; P08913 CHOYP_LOC100373264.1.2 m.35583 sp ADA2A_HUMAN 35.32 453 256 8 7 437 11 448 2.85E-94 294 ADA2A_HUMAN reviewed Alpha-2A adrenergic receptor (Alpha-2 adrenergic receptor subtype C10) (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) ADRA2A ADRA2R ADRAR Homo sapiens (Human) 450 actin cytoskeleton organization [GO:0030036]; activation of MAPK activity by adrenergic receptor signaling pathway [GO:0071883]; activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; acute inflammatory response [GO:0002526]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting adrenergic receptor signaling pathway [GO:0071881]; cellular response to hormone stimulus [GO:0032870]; DNA replication [GO:0006260]; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway [GO:0035625]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; G-protein coupled receptor signaling pathway [GO:0007186]; intestinal absorption [GO:0050892]; movement of cell or subcellular component [GO:0006928]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of adrenergic receptor signaling pathway [GO:0071878]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of calcium ion transmembrane transporter activity [GO:1901020]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of insulin secretion [GO:0046676]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of norepinephrine secretion [GO:0010700]; negative regulation of uterine smooth muscle contraction [GO:0070473]; phospholipase C-activating adrenergic receptor signaling pathway [GO:0071882]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of vasodilation [GO:0045909]; positive regulation of wound healing [GO:0090303]; Ras protein signal transduction [GO:0007265]; regulation of insulin secretion [GO:0050796]; regulation of vasoconstriction [GO:0019229]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; thermoception [GO:0050955] GO:0001819; GO:0002526; GO:0004938; GO:0005737; GO:0005886; GO:0005887; GO:0006260; GO:0006928; GO:0007165; GO:0007186; GO:0007194; GO:0007265; GO:0007266; GO:0007565; GO:0008284; GO:0010700; GO:0016323; GO:0019229; GO:0019901; GO:0030036; GO:0030168; GO:0030335; GO:0030818; GO:0031692; GO:0031696; GO:0031996; GO:0032147; GO:0032148; GO:0032795; GO:0032811; GO:0032870; GO:0035625; GO:0042593; GO:0042803; GO:0043235; GO:0043268; GO:0043406; GO:0045202; GO:0045741; GO:0045909; GO:0045955; GO:0046676; GO:0046982; GO:0050796; GO:0050892; GO:0050955; GO:0050995; GO:0051044; GO:0051379; GO:0051380; GO:0051926; GO:0061179; GO:0070473; GO:0071878; GO:0071880; GO:0071881; GO:0071882; GO:0071883; GO:0090303; GO:1901020 0 0 0 PF00001; P10994 CHOYP_ACT.6.27 m.15626 sp ACTS_PLEWA 92.308 104 8 0 1 104 11 114 2.85E-70 208 ACTS_PLEWA reviewed "Actin, alpha skeletal muscle (Fragment)" 0 Pleurodeles waltl (Iberian ribbed newt) 125 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P16157 CHOYP_AASI_1435.19.35 m.43184 sp ANK1_HUMAN 34.522 785 475 5 1 784 36 782 2.85E-111 377 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20693 CHOYP_FCER2.6.9 m.5966 sp FCER2_MOUSE 35.714 126 74 5 8 129 168 290 2.85E-15 73.9 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P32018 CHOYP_LOC100369879.3.3 m.59095 sp COEA1_CHICK 34.395 157 102 1 25 181 154 309 2.85E-21 104 COEA1_CHICK reviewed Collagen alpha-1(XIV) chain (Undulin) COL14A1 Gallus gallus (Chicken) 1888 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00041;PF00092; P34257 CHOYP_LOC100632850.1.1 m.15093 sp TC3A_CAEEL 26.894 264 178 8 85 343 76 329 2.85E-17 84.7 TC3A_CAEEL reviewed Transposable element Tc3 transposase tc3a B0303.5 Caenorhabditis elegans 329 "developmental process [GO:0032502]; DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074; GO:0032502 0 0 0 PF11427;PF01498; P50133 CHOYP_LOC100718340.1.1 m.48965 sp PTH1R_PIG 33.713 439 271 7 21 447 95 525 2.85E-79 261 PTH1R_PIG reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Sus scrofa (Pig) 585 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular calcium ion homeostasis [GO:0006874]; chondrocyte differentiation [GO:0002062]; negative regulation of cell proliferation [GO:0008285]; osteoblast development [GO:0002076]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cell proliferation [GO:0008284] GO:0002062; GO:0002076; GO:0004991; GO:0005622; GO:0005887; GO:0006874; GO:0007166; GO:0007188; GO:0007189; GO:0007200; GO:0008284; GO:0008285; GO:0017046; GO:0030282; GO:0043621; GO:0045453; GO:0048469; GO:0070062 0 0 0 PF00002;PF02793; P86789 CHOYP_BRAFLDRAFT_93710.1.1 m.28625 sp GIGA6_CRAGI 41.365 249 143 3 30 276 33 280 2.85E-53 186 GIGA6_CRAGI reviewed Gigasin-6 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 302 0 GO:0016021 0 0 0 PF00144; P86854 CHOYP_COLEC12.1.2 m.2785 sp PLCL_MYTGA 32.68 153 93 5 5 149 6 156 2.85E-23 92.4 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q03412 CHOYP_LOC100533354.2.6 m.36737 sp UNC7_CAEEL 40.789 380 212 4 99 471 128 501 2.85E-101 316 UNC7_CAEEL reviewed Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans 522 gap junction assembly [GO:0016264]; ion transmembrane transport [GO:0034220]; locomotion [GO:0040011]; oviposition [GO:0018991]; regulation of pharyngeal pumping [GO:0043051]; response to anesthetic [GO:0072347] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0016264; GO:0018991; GO:0032589; GO:0034220; GO:0040011; GO:0043051; GO:0055077; GO:0072347 0 0 0 PF00876; Q0VC00 CHOYP_ABHD3.1.1 m.46364 sp ABHD3_BOVIN 49.227 388 193 4 21 406 20 405 2.85E-138 404 ABHD3_BOVIN reviewed Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3) ABHD3 Bos taurus (Bovine) 411 lipid metabolic process [GO:0006629]; phosphatidylcholine metabolic process [GO:0046470] GO:0004623; GO:0006629; GO:0008970; GO:0016021; GO:0046470; GO:0052739; GO:0052740 0 0 0 PF00561; Q11212 CHOYP_CYIIB.2.2 m.64545 sp ACT_SPOLI 95.588 68 3 0 25 92 71 138 2.85E-43 142 ACT_SPOLI reviewed Actin (Fragment) 0 Spodoptera littoralis (Egyptian cotton leafworm) 164 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q12955 CHOYP_TVAG_168010.7.45 m.22445 sp ANK3_HUMAN 34.114 299 168 2 1 270 125 423 2.85E-45 166 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q1MSJ5 CHOYP_CSPP1.10.14 m.50197 sp CSPP1_HUMAN 33.936 719 364 24 661 1310 549 1225 2.85E-49 195 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q28C22 CHOYP_OGFD2.1.1 m.35834 sp OGFD2_XENTR 58.427 178 67 2 36 209 174 348 2.85E-69 218 OGFD2_XENTR reviewed 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-) ogfod2 TEgg127j14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 349 0 GO:0005506; GO:0016705; GO:0031418; GO:0051213 0 0 0 0 Q2KI83 CHOYP_DNAJC17.1.1 m.47182 sp DJC17_BOVIN 47.634 317 142 5 9 322 6 301 2.85E-87 267 DJC17_BOVIN reviewed DnaJ homolog subfamily C member 17 DNAJC17 Bos taurus (Bovine) 304 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; toxin transport [GO:1901998]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006351; GO:1901998 0 0 cd06257; PF00226;PF00076; Q3SX45 CHOYP_LOC755521.24.28 m.56887 sp ASB2_BOVIN 37.864 103 58 2 3 105 280 376 2.85E-14 70.9 ASB2_BOVIN reviewed Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) 633 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q3T100 CHOYP_LOC100690646.1.1 m.21213 sp MGST3_BOVIN 43.411 129 66 2 8 129 4 132 2.85E-31 112 MGST3_BOVIN reviewed Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) MGST3 Bos taurus (Bovine) 152 0 GO:0004364; GO:0004602; GO:0005635; GO:0005783; GO:0005789; GO:0016021; GO:0031090; GO:0070062 0 0 0 PF01124; Q460N5 CHOYP_PAR14.3.17 m.27932 sp PAR14_HUMAN 32.898 459 290 9 13 470 1359 1800 2.85E-68 240 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q502K3 CHOYP_LOC764589.1.1 m.13312 sp ANR52_DANRE 32.53 249 162 4 17 262 87 332 2.85E-24 108 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q5F359 CHOYP_LOC100892925.2.2 m.63134 sp TPPC5_CHICK 55.725 131 58 0 2 132 3 133 2.85E-53 169 TPPC5_CHICK reviewed Trafficking protein particle complex subunit 5 TRAPPC5 RCJMB04_33f11 Gallus gallus (Chicken) 188 vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005794; GO:0016192 0 0 cd14943; PF04051; Q5ND28 CHOYP_LOC101175571.1.1 m.62257 sp SREC_MOUSE 29.67 91 42 1 37 105 29 119 2.85E-06 53.1 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5QJC4 CHOYP_DCLRE1A.1.2 m.16626 sp DCR1A_CHICK 55.294 340 150 2 695 1033 626 964 2.85E-133 431 DCR1A_CHICK reviewed DNA cross-link repair 1A protein (SNM1 homolog A) (chSNM1A) DCLRE1A SNM1A Gallus gallus (Chicken) 972 "DNA repair [GO:0006281]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; protection from non-homologous end joining at telomere [GO:0031848]" GO:0000715; GO:0000784; GO:0003684; GO:0005654; GO:0006281; GO:0006303; GO:0031848; GO:0035312; GO:0036297 0 0 0 PF07522; Q5T5Y3 CHOYP_LOC100943158.1.1 m.8683 sp CAMP1_HUMAN 31.762 976 527 33 14 922 18 921 2.85E-95 345 CAMP1_HUMAN reviewed Calmodulin-regulated spectrin-associated protein 1 CAMSAP1 Homo sapiens (Human) 1602 cytoskeleton organization [GO:0007010]; neuron projection development [GO:0031175]; regulation of cell morphogenesis [GO:0022604] GO:0005516; GO:0005737; GO:0005874; GO:0007010; GO:0008017; GO:0022604; GO:0030507; GO:0031175 0 0 0 PF17095;PF11971;PF08683; Q5ZIJ9 CHOYP_BRAFLDRAFT_120990.5.18 m.37188 sp MIB2_CHICK 35.065 77 43 1 644 713 9 85 2.85E-06 55.1 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q64512 CHOYP_LOC100537667.1.1 m.15595 sp PTN13_MOUSE 33.11 598 342 17 1073 1620 1851 2440 2.85E-68 259 PTN13_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (PTP36) (Protein tyrosine phosphatase DPZPTP) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) Ptpn13 Ptp14 Mus musculus (Mouse) 2453 peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066] GO:0004725; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0006470; GO:0014066; GO:0030027; GO:0030496; GO:0035335; GO:0036312; GO:0070062 0 0 0 PF09380;PF00373;PF09379;PF00595;PF00102; Q6DRD9 CHOYP_LOC101163682.1.1 m.10220 sp ABHDB_DANRE 43.956 273 145 4 36 307 51 316 2.85E-78 244 ABHDB_DANRE reviewed Protein ABHD11 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein homolog) abhd11 wbscr21 Danio rerio (Zebrafish) (Brachydanio rerio) 317 0 GO:0016787 0 0 0 PF00561; Q6NS60 CHOYP_FBX41.1.2 m.17992 sp FBX41_MOUSE 46.599 294 157 0 11 304 547 840 2.85E-87 281 FBX41_MOUSE reviewed F-box only protein 41 Fbxo41 D6Ertd538e Kiaa1940 Mus musculus (Mouse) 873 0 0 0 0 0 PF12937; Q6NWZ9 CHOYP_CDO1.1.4 m.26663 sp CDO1_DANRE 56.15 187 81 1 21 207 6 191 2.85E-81 244 CDO1_DANRE reviewed Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) cdo1 Danio rerio (Zebrafish) (Brachydanio rerio) 201 "L-cysteine catabolic process to pyruvate, using cysteine dioxygenase [GO:0019451]; sulfur amino acid biosynthetic process [GO:0000097]; taurine biosynthetic process [GO:0042412]" GO:0000097; GO:0005506; GO:0005829; GO:0017172; GO:0019451; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. 0 0 PF05995; Q6PFX9 CHOYP_TNKS1.2.5 m.18807 sp TNKS1_MOUSE 76.627 338 67 3 4 329 678 1015 2.85E-170 511 TNKS1_MOUSE reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) 1320 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; Q6ZRF8 CHOYP_LOC100370588.7.19 m.24875 sp RN207_HUMAN 24.878 205 139 6 16 218 103 294 2.85E-14 75.5 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q710D3 CHOYP_UN93A.1.3 m.43804 sp UN93A_MOUSE 38.272 243 131 6 76 312 3 232 2.85E-40 149 UN93A_MOUSE reviewed Protein unc-93 homolog A (Unc-93A) Unc93a Mus musculus (Mouse) 458 0 GO:0005886; GO:0016021 0 0 cd06174; PF05978; Q80VI1 CHOYP_LOC100370907.3.3 m.36832 sp TRI56_MOUSE 24.719 267 166 9 18 272 19 262 2.85E-13 75.5 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q8C6K9 CHOYP_LOC100538229.1.1 m.22608 sp CO6A6_MOUSE 21.777 799 541 30 130 897 429 1174 2.85E-29 131 CO6A6_MOUSE reviewed Collagen alpha-6(VI) chain Col6a6 Mus musculus (Mouse) 2265 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; Q8IZ41 CHOYP_LOC580444.2.2 m.59920 sp RASEF_HUMAN 34.697 758 429 17 11 737 16 738 2.85E-119 378 RASEF_HUMAN reviewed Ras and EF-hand domain-containing protein (Ras-related protein Rab-45) RASEF RAB45 Homo sapiens (Human) 740 small GTPase mediated signal transduction [GO:0007264] GO:0005509; GO:0005525; GO:0007264; GO:0048471 0 0 0 PF13499;PF00071; Q8VHE0 CHOYP_BRAFLDRAFT_284846.1.2 m.3406 sp SEC63_MOUSE 39.771 699 370 19 81 759 74 741 2.85E-144 445 SEC63_MOUSE reviewed Translocation protein SEC63 homolog Sec63 Sec63l Mus musculus (Mouse) 760 liver development [GO:0001889]; multicellular organism aging [GO:0010259]; nitrogen compound metabolic process [GO:0006807]; posttranslational protein targeting to membrane [GO:0006620]; renal system development [GO:0072001]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0001889; GO:0005789; GO:0006614; GO:0006620; GO:0006807; GO:0010259; GO:0016020; GO:0016021; GO:0044822; GO:0072001 0 0 cd06257; PF00226;PF02889; Q8W485 CHOYP_LOC101163250.2.3 m.45427 sp Y5010_ARATH 42.609 115 66 0 35 149 74 188 2.85E-25 99.8 Y5010_ARATH reviewed "Uncharacterized protein At5g50100, mitochondrial" At5g50100 MPF21.11 Arabidopsis thaliana (Mouse-ear cress) 214 0 GO:0005739 0 0 0 PF04134; Q96AQ1 CHOYP_LOC100377585.2.3 m.33632 sp CC74A_HUMAN 53.448 58 27 0 69 126 41 98 2.85E-10 64.7 CC74A_HUMAN reviewed Coiled-coil domain-containing protein 74A CCDC74A Homo sapiens (Human) 378 0 0 0 0 0 PF14917; Q99315 CHOYP_contig_006627 m.7544 sp YG31B_YEAST 31.698 795 473 19 246 1028 586 1322 2.85E-109 381 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9CWB7 CHOYP_LOC100552902.1.1 m.27456 sp YD286_MOUSE 56.322 87 38 0 25 111 25 111 2.85E-32 112 YD286_MOUSE reviewed Glutaredoxin-like protein C5orf63 homolog 0 Mus musculus (Mouse) 115 oxidation-reduction process [GO:0055114] GO:0005739; GO:0055114 0 0 0 PF05768; Q9GRC0 CHOYP_LOC100375530.1.1 m.19120 sp MOS_PATPE 50 266 126 4 56 318 65 326 2.85E-84 261 MOS_PATPE reviewed Serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) mos Patiria pectinifera (Starfish) (Asterina pectinifera) 351 female gamete generation [GO:0007292]; female meiosis II [GO:0007147]; negative regulation of mitotic cell cycle [GO:0045930] GO:0004709; GO:0005524; GO:0005622; GO:0007147; GO:0007292; GO:0045930 0 0 0 PF00069; Q9NUV9 CHOYP_LOC100148751.1.1 m.20021 sp GIMA4_HUMAN 40.989 283 135 7 214 479 18 285 2.85E-62 212 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9UA35 CHOYP_LOC574602.1.1 m.44079 sp S28A3_EPTST 42.402 533 275 8 101 607 128 654 2.85E-134 410 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; Q9VFR0 CHOYP_LOC100369270.1.1 m.27019 sp BCCIP_DROME 40.873 252 139 5 62 304 41 291 2.85E-61 199 BCCIP_DROME reviewed Protein BCCIP homolog CG9286 Drosophila melanogaster (Fruit fly) 297 regulation of protein kinase activity [GO:0045859] GO:0019887; GO:0045859 0 0 0 PF13862; A0JM12 CHOYP_MEGF6.10.59 m.23811 sp MEG10_XENTR 41.441 222 111 11 186 402 616 823 2.86E-32 132 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; B2RX88 CHOYP_CSPP1.2.14 m.11075 sp CSPP1_MOUSE 34.483 725 370 24 887 1559 498 1169 2.86E-56 218 CSPP1_MOUSE reviewed Centrosome and spindle pole associated protein 1 Cspp1 Cspp Mus musculus (Mouse) 1205 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 B3EWY9 CHOYP_contig_050919 m.60703 sp MLP_ACRMI 27.528 1068 621 38 824 1828 388 1365 2.86E-95 347 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; D2X5V5 CHOYP_MSMB.3.5 m.27121 sp MSMB_DORPE 34.524 84 44 3 25 107 7 80 2.86E-07 50.4 MSMB_DORPE reviewed Beta-microseminoprotein (Beta-MSP) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 91 behavior [GO:0007610] GO:0005576; GO:0007610 0 0 0 0 E1BD59 CHOYP_BRAFLDRAFT_88224.6.11 m.39213 sp TRI56_BOVIN 25.67 261 158 8 12 248 14 262 2.86E-12 69.3 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O18334 CHOYP_NAEGRDRAFT_59420.2.2 m.55920 sp RAB6_DROME 35.681 213 130 3 3 214 1 207 2.86E-44 149 RAB6_DROME reviewed Ras-related protein Rab6 (Protein warthog) Rab6 wrt CG6601 Drosophila melanogaster (Fruit fly) 208 "axon guidance [GO:0007411]; compound eye morphogenesis [GO:0001745]; defense response to fungus [GO:0050832]; exocytosis [GO:0006887]; germarium-derived egg chamber formation [GO:0007293]; intra-Golgi vesicle-mediated transport [GO:0006891]; oocyte microtubule cytoskeleton polarization [GO:0008103]; photoreceptor cell maintenance [GO:0045494]; phototransduction [GO:0007602]; pole plasm oskar mRNA localization [GO:0045451]; R7 cell development [GO:0045467]; Rab protein signal transduction [GO:0032482]; regulation of postsynaptic membrane potential [GO:0060078]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle-mediated transport [GO:0016192]" GO:0000139; GO:0001745; GO:0003924; GO:0005525; GO:0005794; GO:0005829; GO:0006887; GO:0006890; GO:0006891; GO:0007293; GO:0007411; GO:0007602; GO:0008103; GO:0016023; GO:0016192; GO:0030054; GO:0031982; GO:0032482; GO:0042147; GO:0043025; GO:0043204; GO:0045202; GO:0045451; GO:0045467; GO:0045494; GO:0050832; GO:0060078 0 0 0 PF00071; O42249 CHOYP_GBLP.5.7 m.41211 sp GBLP_ORENI 83.163 196 33 0 1 196 5 200 2.86E-121 349 GBLP_ORENI reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 317 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:2000114; GO:2000543 0 0 0 PF00400; O50655 CHOYP_LOC100372191.1.1 m.24533 sp XERD_SELRU 23.158 285 199 5 161 439 47 317 2.86E-14 77.4 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O70277 CHOYP_BRAFLDRAFT_87336.6.9 m.42094 sp TRIM3_RAT 25.397 126 88 2 23 146 622 743 2.86E-08 55.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75410 CHOYP_TACC1.1.2 m.12149 sp TACC1_HUMAN 36.897 290 171 4 341 620 515 802 2.86E-45 175 TACC1_HUMAN reviewed Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1) TACC1 KIAA1103 Homo sapiens (Human) 805 cell cycle [GO:0007049]; cell division [GO:0051301]; cell proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005634; GO:0005737; GO:0005815; GO:0007049; GO:0008283; GO:0015630; GO:0016020; GO:0021987; GO:0030496; GO:0045111; GO:0051301 0 0 0 PF05010; P05539 CHOYP_LOC100377392.2.4 m.21904 sp CO2A1_RAT 46.512 215 87 4 78 265 732 945 2.86E-23 102 CO2A1_RAT reviewed Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] Col2a1 Rattus norvegicus (Rat) 1419 cartilage development [GO:0051216]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to retinoic acid [GO:0071300]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin E [GO:0071306]; chondrocyte differentiation [GO:0002062]; growth plate cartilage development [GO:0003417]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to X-ray [GO:0010165] GO:0002062; GO:0003417; GO:0005201; GO:0005585; GO:0005737; GO:0009612; GO:0010165; GO:0046872; GO:0051216; GO:0060351; GO:0071260; GO:0071300; GO:0071306; GO:0071316; GO:0071356; GO:0071374; GO:0071375; GO:0071774 0 0 0 PF01410;PF01391; P07291 CHOYP_HNRPR.1.2 m.44126 sp MLE_ARGIR 69.231 143 43 1 1 143 1 142 2.86E-63 196 MLE_ARGIR reviewed "Myosin essential light chain, striated adductor muscle (E-LC) (Sulfhydryl light chain) (SHLC)" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 157 0 GO:0005509; GO:0016459 0 0 0 PF13499; P09478 CHOYP_LOC100533249.1.1 m.29888 sp ACH1_DROME 48.614 541 211 7 1 482 13 545 2.86E-176 509 ACH1_DROME reviewed Acetylcholine receptor subunit alpha-like 1 (Nicotinic acetylcholine receptor alpha 1) nAChRalpha1 Acr96Aa AcrB als nAcRalpha-96Aa CG5610 Drosophila melanogaster (Fruit fly) 567 "cation transport [GO:0006812]; neuromuscular synaptic transmission [GO:0007274]; response to insecticide [GO:0017085]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0006812; GO:0007165; GO:0007271; GO:0007274; GO:0017085; GO:0030054; GO:0035094; GO:0045211 0 0 0 PF02931;PF02932; P10079 CHOYP_TRIADDRAFT_26633.6.6 m.58447 sp FBP1_STRPU 53.226 310 145 0 553 862 210 519 2.86E-92 327 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P16157 CHOYP_LOC579631.4.4 m.52986 sp ANK1_HUMAN 30.717 586 382 6 397 981 139 701 2.86E-71 263 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P24539 CHOYP_AT5F1.1.1 m.12896 sp AT5F1_HUMAN 29.902 204 135 4 54 254 53 251 2.86E-23 98.2 AT5F1_HUMAN reviewed "ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)" ATP5F1 Homo sapiens (Human) 256 ATP biosynthetic process [GO:0006754]; ATP synthesis coupled proton transport [GO:0015986]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; substantia nigra development [GO:0021762] GO:0000276; GO:0005634; GO:0005654; GO:0005739; GO:0005743; GO:0005753; GO:0005759; GO:0006754; GO:0015078; GO:0015986; GO:0016020; GO:0021762; GO:0022857; GO:0042776; GO:0043209; GO:0070062 0 0 0 PF05405; P98170 CHOYP_LOC100079889.1.1 m.50724 sp XIAP_HUMAN 29.651 172 99 6 10 164 17 183 2.86E-10 63.5 XIAP_HUMAN reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) XIAP API3 BIRC4 IAP3 Homo sapiens (Human) 497 cellular response to DNA damage stimulus [GO:0006974]; copper ion homeostasis [GO:0055070]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006974; GO:0008270; GO:0016055; GO:0016874; GO:0030510; GO:0031398; GO:0042127; GO:0042802; GO:0043027; GO:0043066; GO:0043154; GO:0045088; GO:0050727; GO:0055070; GO:0061630; GO:0070424; GO:0090263; GO:1902530; GO:1990001 0 0 0 PF00653; Q01528 CHOYP_HAAF.9.13 m.40855 sp HAAF_LIMPO 39.884 173 99 3 1 172 1 169 2.86E-37 129 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q03601 CHOYP_BRAFLDRAFT_87336.1.9 m.13208 sp NHL1_CAEEL 32.143 112 64 4 84 186 772 880 2.86E-09 58.9 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q08BY5 CHOYP_LOC753089.1.1 m.29353 sp JMJD4_DANRE 61.765 238 90 1 1 237 112 349 2.86E-108 325 JMJD4_DANRE reviewed JmjC domain-containing protein 4 (Jumonji domain-containing protein 4) jmjd4 zgc:153974 Danio rerio (Zebrafish) (Brachydanio rerio) 422 0 0 0 0 0 0 Q08CX1 CHOYP_LOC580444.1.2 m.9066 sp RASEF_XENTR 36.827 706 361 19 23 691 30 687 2.86E-111 356 RASEF_XENTR reviewed Ras and EF-hand domain-containing protein rasef Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 722 small GTPase mediated signal transduction [GO:0007264] GO:0005509; GO:0005525; GO:0007264; GO:0048471 0 0 0 PF13499;PF00071; Q13772 CHOYP_NCOA4.1.1 m.5549 sp NCOA4_HUMAN 26.115 471 237 22 5 429 24 429 2.86E-21 101 NCOA4_HUMAN reviewed Nuclear receptor coactivator 4 (NCoA-4) (Androgen receptor coactivator 70 kDa protein) (70 kDa AR-activator) (70 kDa androgen receptor coactivator) (Androgen receptor-associated protein of 70 kDa) (Ret-activating protein ELE1) NCOA4 ARA70 ELE1 RFG Homo sapiens (Human) 614 "androgen receptor signaling pathway [GO:0030521]; male gonad development [GO:0008584]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0006351; GO:0008584; GO:0030521; GO:0045893; GO:0050681 0 0 0 PF12489; Q2PC93 CHOYP_LOC100497129.4.8 m.38516 sp SSPO_CHICK 40.063 317 168 10 1 307 1283 1587 2.86E-53 212 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q460N5 CHOYP_PARP14.1.22 m.3018 sp PAR14_HUMAN 28.324 346 207 10 8 313 795 1139 2.86E-25 109 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5SZI1 CHOYP_LOC100377643.1.1 m.56881 sp LRAD2_HUMAN 27.041 196 110 9 40 219 35 213 2.86E-07 55.1 LRAD2_HUMAN reviewed Low-density lipoprotein receptor class A domain-containing protein 2 LDLRAD2 Homo sapiens (Human) 272 0 GO:0016021 0 0 0 PF00057; Q5UPG5 CHOYP_V162.1.1 m.3019 sp YL093_MIMIV 27.675 271 179 6 55 317 157 418 2.86E-20 95.9 YL093_MIMIV reviewed Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) 421 0 0 0 0 0 PF00023;PF12796; Q6GMN2 CHOYP_BAIAP2A.1.1 m.2948 sp BAIP2_RAT 35.521 259 158 3 1 257 3 254 2.86E-41 160 BAIP2_RAT reviewed Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53) Baiap2 Rattus norvegicus (Rat) 535 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; dendrite development [GO:0016358]; insulin receptor signaling pathway [GO:0008286]; plasma membrane organization [GO:0007009]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of synaptic plasticity [GO:0048167]; response to bacterium [GO:0009617] GO:0001726; GO:0005829; GO:0005886; GO:0007009; GO:0008093; GO:0008286; GO:0008360; GO:0009617; GO:0014069; GO:0015629; GO:0016358; GO:0030141; GO:0030165; GO:0030175; GO:0030838; GO:0032956; GO:0043025; GO:0043197; GO:0048167; GO:0051017; GO:0051764; GO:0061003; GO:0070062; GO:0070064; GO:2000251 0 0 0 PF08397;PF14604; Q6V0I7 CHOYP_LOC100372197.1.3 m.41593 sp FAT4_HUMAN 30.196 1222 757 39 79 1241 423 1607 2.86E-109 390 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q7T3F7 CHOYP_CHRD1.1.1 m.42143 sp CHRD1_DANRE 53.292 319 139 5 5 317 3 317 2.86E-111 329 CHRD1_DANRE reviewed Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (Morgana) chordc1 zgc:63894 Danio rerio (Zebrafish) (Brachydanio rerio) 341 regulation of centrosome duplication [GO:0010824] GO:0010824; GO:0046872 0 0 0 PF04968;PF04969; Q8BMB3 CHOYP_BRAFLDRAFT_265613.2.2 m.36998 sp IF4E2_MOUSE 66.514 218 69 1 40 253 5 222 2.86E-111 323 IF4E2_MOUSE reviewed Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (eIF4E-2) (mRNA cap-binding protein type 2) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) Eif4e2 Eif4el3 Mus musculus (Mouse) 245 in utero embryonic development [GO:0001701]; negative regulation of translation [GO:0017148] GO:0001701; GO:0003743; GO:0005737; GO:0005845; GO:0017148; GO:0031625; GO:0044822 0 0 0 PF01652; Q8BZ25 CHOYP_TVAG_020440.12.21 m.32732 sp ANKK1_MOUSE 34.926 272 177 0 1 272 427 698 2.86E-47 171 ANKK1_MOUSE reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) 745 0 GO:0004674; GO:0005524 0 0 0 PF00023;PF12796;PF07714; Q8NE00 CHOYP_BRAFLDRAFT_266463.2.2 m.52563 sp TM104_HUMAN 50.877 513 229 10 1 510 1 493 2.86E-164 477 TM104_HUMAN reviewed Transmembrane protein 104 TMEM104 Homo sapiens (Human) 496 0 GO:0016021 0 0 0 PF01490; Q8VHE6 CHOYP_TRIADDRAFT_56463.1.2 m.20951 sp DYH5_MOUSE 29.026 1037 653 24 957 1962 2174 3158 2.86E-138 493 DYH5_MOUSE reviewed "Dynein heavy chain 5, axonemal (Axonemal beta dynein heavy chain 5) (mDNAH5) (Ciliary dynein heavy chain 5)" Dnah5 Dnahc5 Mus musculus (Mouse) 4621 cilium assembly [GO:0042384]; cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; lateral ventricle development [GO:0021670]; outer dynein arm assembly [GO:0036158]; sperm motility [GO:0030317] GO:0003341; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0005930; GO:0007368; GO:0007507; GO:0016887; GO:0021670; GO:0030317; GO:0036157; GO:0036158; GO:0042384 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q8VHS2 CHOYP_BRAFLDRAFT_64071.1.35 m.3422 sp CRUM1_MOUSE 45.783 83 29 3 4919 4999 154 222 2.86E-09 67.8 CRUM1_MOUSE reviewed Protein crumbs homolog 1 Crb1 Mus musculus (Mouse) 1405 eye photoreceptor cell development [GO:0042462]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009] GO:0005509; GO:0005886; GO:0005902; GO:0007009; GO:0016021; GO:0042462; GO:0061024 0 0 0 PF00008;PF12661;PF02210; Q91WF7 CHOYP_FIG4.2.2 m.66999 sp FIG4_MOUSE 65 140 49 0 1 140 490 629 2.86E-63 212 FIG4_MOUSE reviewed "Polyphosphoinositide phosphatase (EC 3.1.3.-) (Phosphatidylinositol 3,5-bisphosphate 5-phosphatase) (SAC domain-containing protein 3)" Fig4 Kiaa0274 Sac3 Mus musculus (Mouse) 907 locomotory behavior [GO:0007626]; myelin assembly [GO:0032288]; negative regulation of myelination [GO:0031642]; neuron development [GO:0048666]; phosphatidylinositol metabolic process [GO:0046488]; pigmentation [GO:0043473]; positive regulation of neuron projection development [GO:0010976]; vacuole organization [GO:0007033] GO:0004438; GO:0005783; GO:0005794; GO:0007033; GO:0007626; GO:0010008; GO:0010976; GO:0031642; GO:0032288; GO:0034593; GO:0043473; GO:0043812; GO:0046488; GO:0048666; GO:0055037 0 0 0 PF02383; Q92752 CHOYP_IRF1.3.3 m.59044 sp TENR_HUMAN 23.193 664 428 27 284 932 332 928 2.86E-11 71.6 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q95KE5 CHOYP_LOC657466.1.1 m.38710 sp RM43_BOVIN 41.176 136 80 0 111 246 1 136 2.86E-29 112 RM43_BOVIN reviewed "39S ribosomal protein L43, mitochondrial (L43mt) (MRP-L43) (Retina-specific 15.7 kDa protein)" MRPL43 Bos taurus (Bovine) 159 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005762; GO:0070124; GO:0070125 0 0 0 PF05047; Q95WA0 CHOYP_LOC585872.4.6 m.52326 sp RL26_LITLI 80.851 141 25 1 1 139 1 141 2.86E-79 233 RL26_LITLI reviewed 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) 144 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 0 PF00467;PF16906; Q9C040 CHOYP_BRAFLDRAFT_69798.12.22 m.45951 sp TRIM2_HUMAN 22.719 537 287 21 106 572 118 596 2.86E-11 70.1 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9D722 CHOYP_BRAFLDRAFT_284112.1.1 m.11617 sp OSER1_MOUSE 60.976 41 14 1 277 315 250 290 2.86E-08 57.8 OSER1_MOUSE reviewed Oxidative stress-responsive serine-rich protein 1 (Oxidative stress-responsive protein 1) (Peroxide-inducible transcript 1 protein) Oser1 Mus musculus (Mouse) 291 cellular response to hydrogen peroxide [GO:0070301] GO:0070301 0 0 0 PF05604; Q9D722 CHOYP_RL8.8.10 m.59039 sp OSER1_MOUSE 60.976 41 14 1 277 315 250 290 2.86E-08 57.8 OSER1_MOUSE reviewed Oxidative stress-responsive serine-rich protein 1 (Oxidative stress-responsive protein 1) (Peroxide-inducible transcript 1 protein) Oser1 Mus musculus (Mouse) 291 cellular response to hydrogen peroxide [GO:0070301] GO:0070301 0 0 0 PF05604; Q9EQ32 CHOYP_BRAFLDRAFT_118043.1.1 m.26278 sp BCAP_MOUSE 25.592 211 128 8 247 439 267 466 2.86E-06 55.1 BCAP_MOUSE reviewed Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) Pik3ap1 Bcap Mus musculus (Mouse) 811 negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] GO:0005737; GO:0005829; GO:0005886; GO:0014068; GO:0016020; GO:0034122; GO:0034123; GO:0034134; GO:0034142; GO:0034154; GO:0034162; GO:0036312; GO:0042802; GO:0050727 0 0 0 PF14545; Q9HC84 CHOYP_TVAG_198570.7.8 m.59638 sp MUC5B_HUMAN 30.108 186 110 5 562 735 3388 3565 2.86E-09 66.6 MUC5B_HUMAN reviewed "Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin)" MUC5B MUC5 Homo sapiens (Human) 5762 defense response to bacterium [GO:0042742]; O-glycan processing [GO:0016266]; regulation of macrophage activation [GO:0043030] GO:0005615; GO:0005796; GO:0016266; GO:0042742; GO:0043030; GO:0043231; GO:0070062 0 0 0 PF08742;PF13330;PF01826;PF00093;PF00094; A6QLU6 CHOYP_GP133.2.2 m.48064 sp AGRD1_BOVIN 27.154 534 315 17 16 510 350 848 2.87E-47 181 AGRD1_BOVIN reviewed Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) ADGRD1 GPR133 Bos taurus (Bovine) 902 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579] GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0010579; GO:0016021 0 0 0 PF00002;PF01825; B5DGL6 CHOYP_RS3A.1.15 m.2270 sp RS3A_SALSA 78.226 124 22 1 1 124 22 140 2.87E-67 206 RS3A_SALSA reviewed 40S ribosomal protein S3a rps3a Salmo salar (Atlantic salmon) 266 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; C7G0B5 CHOYP_PIF.5.6 m.44293 sp PIF_PINFU 26.575 508 339 10 586 1066 26 526 2.87E-51 200 PIF_PINFU reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 1007 chitin metabolic process [GO:0006030] GO:0005578; GO:0006030; GO:0008061 0 0 0 PF00092; D3KCC4 CHOYP_CARNS1.4.6 m.40249 sp CRNS1_CHICK 40.909 66 39 0 41 106 54 119 2.87E-07 51.6 CRNS1_CHICK reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 Gallus gallus (Chicken) 930 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_69798.4.22 m.32469 sp TRIM3_RAT 25.161 155 110 3 37 189 593 743 2.87E-07 53.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P11928 CHOYP_BRAFLDRAFT_66571.1.1 m.16030 sp OAS1A_MOUSE 41.935 93 47 2 75 163 5 94 2.87E-12 68.2 OAS1A_MOUSE reviewed 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) 367 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral process [GO:0048525]; purine nucleotide biosynthetic process [GO:0006164]; response to virus [GO:0009615] GO:0001730; GO:0003725; GO:0005524; GO:0005634; GO:0005739; GO:0005783; GO:0006164; GO:0009615; GO:0045087; GO:0046872; GO:0048525; GO:0051607 0 0 0 PF01909;PF10421; P18754 CHOYP_LOC754700.1.2 m.19280 sp RCC1_HUMAN 50 322 155 5 21 340 20 337 2.87E-102 310 RCC1_HUMAN reviewed Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) RCC1 CHC1 Homo sapiens (Human) 421 cell division [GO:0051301]; chromosome segregation [GO:0007059]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]; viral process [GO:0016032] GO:0000082; GO:0000790; GO:0000794; GO:0003682; GO:0005087; GO:0005634; GO:0005654; GO:0005737; GO:0007052; GO:0007059; GO:0007067; GO:0007088; GO:0016032; GO:0031492; GO:0031965; GO:0042393; GO:0051225; GO:0051301 0 0 0 PF00415; P59722 CHOYP_BRAFLDRAFT_117719.3.3 m.61062 sp EGLN1_RAT 64.407 118 40 2 1 118 214 329 2.87E-46 167 EGLN1_RAT reviewed Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (Fragment) Egln1 Rattus norvegicus (Rat) 338 negative regulation of CAMKK-AMPK signaling cascade [GO:1905290]; negative regulation of cAMP catabolic process [GO:0030821]; negative regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051344]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron death [GO:1901216]; regulation of angiogenesis [GO:0045765]; response to hypoxia [GO:0001666]; response to nitric oxide [GO:0071731] GO:0001666; GO:0005506; GO:0005634; GO:0005829; GO:0019899; GO:0030821; GO:0031418; GO:0031543; GO:0043065; GO:0043433; GO:0045765; GO:0051344; GO:0071731; GO:1901216; GO:1905290 0 0 0 PF13640; Q06806 CHOYP_LOC101072623.3.4 m.32295 sp TIE1_MOUSE 32.584 89 56 3 37 122 244 331 2.87E-08 58.2 TIE1_MOUSE reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) 1134 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; response to retinoic acid [GO:0032526]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001701; GO:0004714; GO:0005524; GO:0005886; GO:0016021; GO:0016525; GO:0030336; GO:0032526; GO:0045026 0 0 0 PF00041;PF00047;PF07714; Q06852 CHOYP_GSPATT00029150001.2.2 m.26558 sp SLAP1_CLOTH 57.595 316 79 24 133 396 1388 1700 2.87E-24 112 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q08C33 CHOYP_BRAFLDRAFT_264316.1.1 m.29655 sp ISOC1_DANRE 54.737 190 84 1 8 197 92 279 2.87E-75 230 ISOC1_DANRE reviewed Isochorismatase domain-containing protein 1 isoc1 zgc:153699 Danio rerio (Zebrafish) (Brachydanio rerio) 283 metabolic process [GO:0008152] GO:0003824; GO:0005737; GO:0008152 0 0 0 PF00857; Q2PZL6 CHOYP_LOC660465.2.2 m.29540 sp FAT4_MOUSE 29.19 531 302 16 5 515 1797 2273 2.87E-44 171 FAT4_MOUSE reviewed Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0008543; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072006; GO:0072137; GO:0072307 0 0 0 PF00028;PF00008;PF07645;PF12661;PF02210; Q2T9P4 CHOYP_NASP.3.4 m.18758 sp NASP_BOVIN 38.889 90 52 3 2 90 24 111 2.87E-10 58.5 NASP_BOVIN reviewed Nuclear autoantigenic sperm protein (NASP) NASP Bos taurus (Bovine) 777 blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone exchange [GO:0043486]; protein transport [GO:0015031] GO:0000790; GO:0001824; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006335; GO:0006336; GO:0007049; GO:0008283; GO:0015031; GO:0043234; GO:0043486; GO:0051879 0 0 0 PF10516; Q502M6 CHOYP_LOC100633999.1.1 m.21840 sp ANR29_DANRE 38.172 186 115 0 7 192 43 228 2.87E-37 134 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5NBU5 CHOYP_LOC100548823.1.1 m.45956 sp FBX39_MOUSE 24.257 404 281 10 7 397 14 405 2.87E-32 130 FBX39_MOUSE reviewed F-box only protein 39 Fbxo39 Mus musculus (Mouse) 443 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0019005; GO:0031146 0 0 0 PF12937; Q5PQR5 CHOYP_BRAFLDRAFT_279143.1.1 m.50630 sp IMP4_RAT 65.95 279 94 1 23 301 12 289 2.87E-143 407 IMP4_RAT reviewed U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) Imp4 Rattus norvegicus (Rat) 291 rRNA processing [GO:0006364] GO:0006364; GO:0030515; GO:0032040; GO:0034457; GO:0042134 0 0 0 PF04427; Q5XHC1 CHOYP_LOC591073.1.1 m.50375 sp CD047_XENLA 53.205 312 127 5 27 331 4 303 2.87E-104 310 CD047_XENLA reviewed UPF0602 protein C4orf47 homolog 0 Xenopus laevis (African clawed frog) 307 0 GO:0005737; GO:0005813 0 0 0 PF15239; Q62656 CHOYP_PTPRZ.3.9 m.21034 sp PTPRZ_RAT 32.053 599 358 15 491 1047 1700 2291 2.87E-77 282 PTPRZ_RAT reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (3F8 chondroitin sulfate proteoglycan) (3H1 keratan sulfate proteoglycan) (Phosphacan) Ptprz1 Ptprz Ptpz Rattus norvegicus (Rat) 2316 axonal fasciculation [GO:0007413]; brain development [GO:0007420]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; neuron development [GO:0048666]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of cell migration [GO:0030335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; protein dephosphorylation [GO:0006470]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0004725; GO:0005615; GO:0005737; GO:0006470; GO:0007413; GO:0007420; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0010976; GO:0016020; GO:0016021; GO:0016791; GO:0017134; GO:0021766; GO:0030027; GO:0030175; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048666; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; Q69Z37 CHOYP_LOC100367242.1.2 m.48297 sp SAM9L_MOUSE 25.277 1084 708 38 57 1101 168 1188 2.87E-70 265 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6DDL7 CHOYP_UNC93A.1.2 m.15480 sp UN93A_XENLA 30.925 346 209 6 189 528 2 323 2.87E-38 150 UN93A_XENLA reviewed Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) 460 0 GO:0016021 0 0 cd06174; PF05978; Q6DFV8 CHOYP_VWDE.12.13 m.48819 sp VWDE_MOUSE 29.722 360 215 16 1 345 298 634 2.87E-33 141 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6QMZ4 CHOYP_LOC100186361.1.3 m.17830 sp RL6_CHILA 65.152 66 20 2 1 65 112 175 2.87E-17 78.6 RL6_CHILA reviewed 60S ribosomal protein L6 RPL6 Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) 288 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01159;PF03868; Q7L2H7 CHOYP_MABP1.1.2 m.21699 sp EIF3M_HUMAN 52.8 375 173 2 7 381 1 371 2.87E-141 409 EIF3M_HUMAN reviewed Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1) EIF3M HFLB5 PCID1 GA17 PNAS-125 Homo sapiens (Human) 374 cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0002183; GO:0003743; GO:0005829; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290; GO:0071541 0 0 0 PF01399; Q8AYG3 CHOYP_TTK.1.1 m.6202 sp TTK_DANRE 49.371 318 137 9 450 759 616 917 2.87E-88 302 TTK_DANRE reviewed Dual specificity protein kinase Ttk (EC 2.7.12.1) (Mitotic checkpoint serine/threonine-protein kinase Mps1) (Monopolar spindle protein 1) (Protein nightcap) ttk mps1 ncp Danio rerio (Zebrafish) (Brachydanio rerio) 982 anatomical structure homeostasis [GO:0060249]; cell division [GO:0051301]; chromosome separation [GO:0051304]; embryo development [GO:0009790]; female meiosis chromosome segregation [GO:0016321]; fin regeneration [GO:0031101]; male meiosis chromosome segregation [GO:0007060]; mitotic cell cycle checkpoint [GO:0007093]; tissue regeneration [GO:0042246] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0007060; GO:0007093; GO:0009790; GO:0016321; GO:0031101; GO:0042246; GO:0046872; GO:0051301; GO:0051304; GO:0060249 0 0 0 PF00069; Q8BGW8 CHOYP_SI_DKEYP-93D12.1.1.1 m.615 sp VGLL2_MOUSE 39.831 118 58 4 66 171 66 182 2.87E-14 74.7 VGLL2_MOUSE reviewed Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1) Vgll2 Vgl2 Vito1 Mus musculus (Mouse) 322 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; skeletal muscle tissue development [GO:0007519]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005737; GO:0006351; GO:0007519; GO:0008022; GO:0045944 0 0 0 PF07545; Q8BLA8 CHOYP_LOC100372296.1.1 m.30211 sp TRPA1_MOUSE 29.293 297 198 4 14 306 788 1076 2.87E-33 133 TRPA1_MOUSE reviewed Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) Trpa1 Anktm1 Mus musculus (Mouse) 1125 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to drug [GO:0042493]; response to hydrogen peroxide [GO:0042542]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; response to pain [GO:0048265]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955] GO:0005216; GO:0005262; GO:0005887; GO:0006816; GO:0007166; GO:0009409; GO:0010033; GO:0014070; GO:0015267; GO:0015278; GO:0016021; GO:0019233; GO:0032421; GO:0042493; GO:0042542; GO:0048265; GO:0050955; GO:0050966; GO:0050968; GO:0051289; GO:0070588; GO:0097604 0 0 0 PF12796;PF00520; Q91ZW8 CHOYP_CLC4M.2.2 m.42922 sp C209D_MOUSE 37.121 132 76 3 25 154 102 228 2.87E-18 81.3 C209D_MOUSE reviewed CD209 antigen-like protein D (DC-SIGN-related protein 3) (DC-SIGNR3) (CD antigen CD209) Cd209d Mus musculus (Mouse) 237 defense response to bacterium [GO:0042742]; endocytosis [GO:0006897]; positive regulation of cytokine secretion [GO:0050715] GO:0005537; GO:0006897; GO:0016021; GO:0042742; GO:0042803; GO:0046872; GO:0050715 0 0 0 PF00059; Q924T2 CHOYP_LOC100232691.1.1 m.15025 sp RT02_MOUSE 55.288 208 92 1 99 306 61 267 2.87E-80 248 RT02_MOUSE reviewed "28S ribosomal protein S2, mitochondrial (MRP-S2) (S2mt)" Mrps2 Mus musculus (Mouse) 291 mitochondrial translation [GO:0032543]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; translation [GO:0006412]; xenophagy [GO:0098792] GO:0002230; GO:0003735; GO:0005739; GO:0005763; GO:0006412; GO:0032543; GO:0098779; GO:0098792 0 0 cd01425; PF00318; Q93129 CHOYP_LOC101072885.1.1 m.63778 sp ACTC_BRABE 94.672 244 13 0 2 245 1 244 2.87E-174 489 ACTC_BRABE reviewed "Actin, cytoplasmic (BbCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma belcheri (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9BY84 CHOYP_LOC100366454.1.1 m.26151 sp DUS16_HUMAN 52.358 212 92 3 13 221 96 301 2.87E-70 232 DUS16_HUMAN reviewed Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) DUSP16 KIAA1700 MKP7 Homo sapiens (Human) 665 "dephosphorylation [GO:0016311]; inactivation of MAPK activity [GO:0000188]; MAPK export from nucleus [GO:0045204]; MAPK phosphatase export from nucleus, leptomycin B sensitive [GO:0045209]" GO:0000188; GO:0004721; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016023; GO:0016311; GO:0016791; GO:0017017; GO:0045204; GO:0045209 0 0 0 PF00782;PF00581; Q9DB15 CHOYP_LOC100377184.1.1 m.16090 sp RM12_MOUSE 44.767 172 86 2 38 201 31 201 2.87E-36 128 RM12_MOUSE reviewed "39S ribosomal protein L12, mitochondrial (L12mt) (MRP-L12)" Mrpl12 Rpml12 Mus musculus (Mouse) 201 "positive regulation of transcription, DNA-templated [GO:0045893]; transcription from mitochondrial promoter [GO:0006390]; translation [GO:0006412]" GO:0003735; GO:0005739; GO:0005761; GO:0005762; GO:0006390; GO:0006412; GO:0045893 0 0 cd00387; PF00542;PF16320; Q9H2A9 CHOYP_LOC100890714.1.1 m.6897 sp CHST8_HUMAN 27.344 256 163 7 79 318 153 401 2.87E-18 90.1 CHST8_HUMAN reviewed Carbohydrate sulfotransferase 8 (EC 2.8.2.-) (GalNAc-4-O-sulfotransferase 1) (GalNAc-4-ST1) (GalNAc4ST-1) (N-acetylgalactosamine-4-O-sulfotransferase 1) CHST8 Homo sapiens (Human) 424 carbohydrate biosynthetic process [GO:0016051]; central nervous system development [GO:0007417]; hormone biosynthetic process [GO:0042446]; proteoglycan biosynthetic process [GO:0030166]; sulfur compound metabolic process [GO:0006790] GO:0000139; GO:0001537; GO:0006790; GO:0007417; GO:0016021; GO:0016051; GO:0030166; GO:0042446 0 0 0 PF03567; Q9HCX4 CHOYP_TRPC4.1.1 m.9499 sp TRPC7_HUMAN 35.606 264 123 11 1 257 617 840 2.87E-40 155 TRPC7_HUMAN reviewed Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7) TRPC7 TRP7 Homo sapiens (Human) 862 calcium ion transmembrane transport [GO:0070588]; manganese ion transport [GO:0006828]; platelet activation [GO:0030168]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338] GO:0005262; GO:0005635; GO:0005801; GO:0005886; GO:0005887; GO:0006828; GO:0007338; GO:0015279; GO:0030168; GO:0048471; GO:0051480; GO:0070588 0 0 0 PF12796;PF00520;PF08344; Q9QXA5 CHOYP_LSM4.1.3 m.2601 sp LSM4_MOUSE 85.149 101 8 2 1 101 1 94 2.87E-58 179 LSM4_MOUSE reviewed U6 snRNA-associated Sm-like protein LSm4 Lsm4 Mus musculus (Mouse) 137 cytoplasmic mRNA processing body assembly [GO:0033962]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of defense response to virus by host [GO:0002230]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; xenophagy [GO:0098792] GO:0000245; GO:0000387; GO:0000932; GO:0000956; GO:0002230; GO:0005654; GO:0005681; GO:0005688; GO:0005737; GO:0017070; GO:0033962; GO:0044822; GO:0097526; GO:0098779; GO:0098792 0 0 0 PF01423; Q9UKX7 CHOYP_NUP50.1.1 m.17104 sp NUP50_HUMAN 49.412 170 68 5 547 701 292 458 2.87E-37 149 NUP50_HUMAN reviewed Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) NUP50 NPAP60L PRO1146 Homo sapiens (Human) 468 gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; protein import into nucleus [GO:0006606]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005643; GO:0005654; GO:0005737; GO:0006406; GO:0006409; GO:0006606; GO:0007077; GO:0008536; GO:0010827; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031965; GO:0075733; GO:1900034 0 0 0 PF08911;PF00638; Q9V0D5 CHOYP_LOC101069440.2.3 m.16645 sp MDH_PYRAB 40.055 362 191 10 4 352 9 357 2.87E-74 237 MDH_PYRAB reviewed Malate dehydrogenase (EC 1.1.1.37) mdh PYRAB08550 PAB1791 Pyrococcus abyssi (strain GE5 / Orsay) 362 tricarboxylic acid cycle [GO:0006099] GO:0005737; GO:0006099; GO:0030060 0 0 0 PF02615; A4IF63 CHOYP_BRAFLDRAFT_87294.6.6 m.64622 sp TRIM2_BOVIN 31.068 103 69 1 25 125 627 729 2.88E-08 54.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6H619 CHOYP_LOC100476601.1.1 m.9343 sp PHRF1_MOUSE 35.447 615 312 19 41 617 23 590 2.88E-74 278 PHRF1_MOUSE reviewed PHD and RING finger domain-containing protein 1 Phrf1 Kiaa1542 Mus musculus (Mouse) 1682 mRNA processing [GO:0006397]; transcription from RNA polymerase II promoter [GO:0006366] GO:0006366; GO:0006397; GO:0008270; GO:0016020; GO:0070063 0 0 0 PF00628;PF13639; A6QLU6 CHOYP_GP133.1.2 m.42683 sp AGRD1_BOVIN 43.299 97 49 2 1 93 754 848 2.88E-17 83.2 AGRD1_BOVIN reviewed Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) ADGRD1 GPR133 Bos taurus (Bovine) 902 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579] GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0010579; GO:0016021 0 0 0 PF00002;PF01825; O88281 CHOYP_LOC101160063.3.4 m.4839 sp MEGF6_RAT 39.106 179 87 7 209 374 767 936 2.88E-23 105 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P08635 CHOYP_OLAH.1.2 m.1254 sp SAST_RAT 39.6 250 143 3 3 249 13 257 2.88E-62 199 SAST_RAT reviewed "S-acyl fatty acid synthase thioesterase, medium chain (EC 3.1.2.14) (Oleoyl-ACP hydrolase) (Thioesterase II) (Thioesterase domain-containing protein 1)" Olah Mch Thedc1 Rattus norvegicus (Rat) 263 fatty acid biosynthetic process [GO:0006633]; lipid biosynthetic process [GO:0008610]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338] GO:0004320; GO:0005829; GO:0006633; GO:0008610; GO:0016295; GO:0016296; GO:0016297; GO:0035338 0 0 0 PF00975; P21613 CHOYP_KHC1.1.2 m.50292 sp KINH_DORPE 70.455 88 21 2 15 102 849 931 2.88E-30 119 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P42577 CHOYP_FRIS.11.11 m.66639 sp FRIS_LYMST 83.846 130 21 0 1 130 1 130 2.88E-78 231 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P50901 CHOYP_HXD3.1.1 m.40287 sp HOX3_BRAFL 67.241 116 23 3 105 220 97 197 2.88E-40 151 HOX3_BRAFL reviewed Homeobox protein HOX3 0 Branchiostoma floridae (Florida lancelet) (Amphioxus) 411 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007275; GO:0043565 0 0 0 PF00046; P51957 CHOYP_NEK5.1.1 m.45206 sp NEK4_HUMAN 47.531 162 79 3 1 161 129 285 2.88E-41 157 NEK4_HUMAN reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) 841 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; P57102 CHOYP_HAND1.1.1 m.10874 sp HAND2_DANRE 49.315 219 81 7 12 217 6 207 2.88E-54 175 HAND2_DANRE reviewed "Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)" hand2 dhand Danio rerio (Zebrafish) (Brachydanio rerio) 208 "cardiac muscle cell differentiation [GO:0055007]; cardioblast differentiation [GO:0010002]; cardiocyte differentiation [GO:0035051]; cardiogenic plate morphogenesis [GO:0003142]; determination of intestine left/right asymmetry [GO:0071908]; embryonic heart tube formation [GO:0003144]; embryonic pectoral fin morphogenesis [GO:0035118]; embryonic viscerocranium morphogenesis [GO:0048703]; heart contraction [GO:0060047]; heart morphogenesis [GO:0003007]; noradrenergic neuron differentiation [GO:0003357]; polarized epithelial cell differentiation [GO:0030859]; proepicardium development [GO:0003342]; regulation of transcription, DNA-templated [GO:0006355]; sympathetic nervous system development [GO:0048485]; thyroid gland development [GO:0030878]; transcription, DNA-templated [GO:0006351]" GO:0003007; GO:0003142; GO:0003144; GO:0003342; GO:0003357; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0010002; GO:0030859; GO:0030878; GO:0035051; GO:0035118; GO:0048485; GO:0048703; GO:0055007; GO:0060047; GO:0071908 0 0 0 PF00010; P83299 CHOYP_CAH1.1.2 m.24247 sp CAH1_CHIHA 44.403 268 135 9 24 288 3 259 2.88E-65 208 CAH1_CHIHA reviewed Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase I) (CA-I) (Ice-CA) ca1 Chionodraco hamatus (Antarctic teleost icefish) (Chaenichthys rhinoceratus hamatus) 259 one-carbon metabolic process [GO:0006730] GO:0004089; GO:0005737; GO:0006730; GO:0008270 0 0 0 PF00194; Q06730 CHOYP_XFIN.4.4 m.54847 sp ZN33A_HUMAN 21.337 389 235 14 36 379 323 685 2.88E-08 61.6 ZN33A_HUMAN reviewed Zinc finger protein 33A (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK) (Zinc finger protein 11A) (Zinc finger protein KOX31) ZNF33A KIAA0065 KOX31 ZNF11 ZNF11A ZNF33 Homo sapiens (Human) 810 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q28GL6 CHOYP_LOC100562491.1.1 m.13197 sp S7A6O_XENTR 26.543 324 161 13 227 538 3 261 2.88E-08 59.3 S7A6O_XENTR reviewed Probable RNA polymerase II nuclear localization protein SLC7A6OS (Solute carrier family 7 member 6 opposite strand transcript homolog) slc7a6os TEgg029j19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 314 midbrain-hindbrain boundary structural organization [GO:0021552]; protein transport [GO:0015031]; somite development [GO:0061053] GO:0005634; GO:0005737; GO:0015031; GO:0021552; GO:0061053 0 0 0 PF08574; Q54NE6 CHOYP_GPMA.1.1 m.35689 sp PGAM_DICDI 67.611 247 80 0 4 250 3 249 2.88E-122 350 PGAM_DICDI reviewed Probable phosphoglycerate mutase (EC 3.1.3.13) (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM) (dPGM) gpmA pgam DDB_G0285311 Dictyostelium discoideum (Slime mold) 249 gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; regulation of pentose-phosphate shunt [GO:0043456] GO:0004082; GO:0004083; GO:0004619; GO:0005829; GO:0006094; GO:0006096; GO:0043456; GO:0045335; GO:0046538 0 0 cd07067; PF00300; Q568R1 CHOYP_NSRP1.1.1 m.4860 sp NSRP1_DANRE 41.573 89 36 2 1 87 150 224 2.88E-09 60.5 NSRP1_DANRE reviewed Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) nsrp1 ccdc55 wu:fc14d05 zgc:152777 Danio rerio (Zebrafish) (Brachydanio rerio) 516 0 0 0 0 0 PF09745; Q5FWF7 CHOYP_FBXO48.1.1 m.33501 sp FBX48_HUMAN 31.852 135 87 1 2 136 26 155 2.88E-22 89 FBX48_HUMAN reviewed F-box only protein 48 FBXO48 FBX48 Homo sapiens (Human) 155 0 0 0 0 0 PF12937; Q5U4U6 CHOYP_T23O.1.6 m.26261 sp T23O_XENLA 38.8 250 136 5 1 234 135 383 2.88E-50 172 T23O_XENLA reviewed "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" tdo2 Xenopus laevis (African clawed frog) 406 tryptophan catabolic process to kynurenine [GO:0019441] GO:0004833; GO:0019441; GO:0020037; GO:0046872 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}. 0 0 PF03301; Q5ZKF6 CHOYP_5NT3.1.1 m.24925 sp 5NT3B_CHICK 49.474 285 144 0 4 288 2 286 2.88E-97 290 5NT3B_CHICK reviewed 7-methylguanosine phosphate-specific 5'-nucleotidase (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3B) (Cytosolic 5'-nucleotidase III-like protein) (cN-III-like protein) (EC 3.1.3.5) (N(7)-methylguanylate 5'-phosphatase) NT5C3B NT5C3L RCJMB04_11c18 Gallus gallus (Chicken) 289 nucleotide metabolic process [GO:0009117] GO:0000166; GO:0000287; GO:0005737; GO:0008253; GO:0009117 0 0 0 PF05822; Q5ZML3 CHOYP_ISCW_ISCW014398.1.3 m.15839 sp SRSF1_CHICK 74.566 173 35 2 4 175 13 177 2.88E-73 224 SRSF1_CHICK reviewed "Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1)" SRSF1 SFRS1 RCJMB04_1l5 Gallus gallus (Chicken) 257 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005737; GO:0006397; GO:0008380; GO:0016607 0 0 0 PF00076; Q689D1 CHOYP_TLR2.6.7 m.54975 sp TLR2_CANLF 26.786 784 431 36 64 759 55 783 2.88E-40 162 TLR2_CANLF reviewed Toll-like receptor 2 (CD antigen CD282) TLR2 Canis lupus familiaris (Dog) (Canis familiaris) 785 cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of inflammatory response [GO:0050729]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0006954; GO:0016021; GO:0030670; GO:0031226; GO:0034134; GO:0045087; GO:0045121; GO:0050707; GO:0050729; GO:0071726; GO:0071727 0 0 0 PF13855;PF01463;PF01582; Q69Z37 CHOYP_LOC100368821.1.7 m.4193 sp SAM9L_MOUSE 27.657 781 487 29 6 755 386 1119 2.88E-55 212 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6DRP4 CHOYP_CCM2.1.1 m.31917 sp CCM2_DANRE 30.372 349 192 10 75 383 62 399 2.88E-37 144 CCM2_DANRE reviewed Cerebral cavernous malformations protein 2 homolog (Malcavernin) (Valentine) ccm2 vtn Danio rerio (Zebrafish) (Brachydanio rerio) 455 anterior/posterior axis specification [GO:0009948]; cell-cell junction assembly [GO:0007043]; heart contraction [GO:0060047]; heart development [GO:0007507]; vasculogenesis [GO:0001570] GO:0001570; GO:0005737; GO:0007043; GO:0007507; GO:0009948; GO:0060047 0 0 cd13516; PF16545; Q6P963 CHOYP_BRAFLDRAFT_104472.1.1 m.16220 sp GLO2_DANRE 57.86 299 120 3 21 315 3 299 2.88E-127 368 GLO2_DANRE reviewed "Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)" hagh zgc:73161 Danio rerio (Zebrafish) (Brachydanio rerio) 303 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] GO:0004416; GO:0005759; GO:0019243; GO:0046872 0 0 0 PF16123;PF00753; Q8BX70 CHOYP_BRAFLDRAFT_88208.3.3 m.34799 sp VP13C_MOUSE 29.732 1342 792 33 2121 3416 2475 3711 2.88E-144 512 VP13C_MOUSE reviewed Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) 3748 mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0005741; GO:0005829; GO:0006623; GO:0007005; GO:0019898; GO:0045053; GO:0070062; GO:1905090 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q8K0U4 CHOYP_HS12A.5.33 m.25567 sp HS12A_MOUSE 34.672 473 248 11 2 419 196 662 2.88E-74 248 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8WPJ2 CHOYP_MANA.1.3 m.1054 sp MANA_MYTED 37.538 325 174 9 4 327 61 357 2.88E-64 211 MANA_MYTED reviewed "Mannan endo-1,4-beta-mannosidase (EC 3.2.1.78) (Beta-mannanase) (Endo-beta-1,4-mannanase) (Man5A) (ManA)" 0 Mytilus edulis (Blue mussel) 367 mannan catabolic process [GO:0046355] GO:0016985; GO:0046355 0 0 0 PF00150; Q9BPU9 CHOYP_BRAFLDRAFT_87511.1.1 m.40371 sp B9D2_HUMAN 70.857 175 51 0 1 175 1 175 2.88E-97 281 B9D2_HUMAN reviewed B9 domain-containing protein 2 (MKS1-related protein 2) B9D2 MKSR2 Homo sapiens (Human) 175 cilium assembly [GO:0042384]; sister chromatid cohesion [GO:0007062] GO:0005634; GO:0005813; GO:0005829; GO:0007062; GO:0016020; GO:0036038; GO:0036064; GO:0042384; GO:0043015 0 0 0 PF07162; Q9BQS2 CHOYP_LOC100377666.1.1 m.14681 sp SYT15_HUMAN 44.127 315 170 2 97 409 105 415 2.88E-90 283 SYT15_HUMAN reviewed Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV) SYT15 Homo sapiens (Human) 421 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019905; GO:0030276; GO:0048791; GO:0098793 0 0 0 PF00168; Q9H2M3 CHOYP_LOC100371248.2.2 m.48460 sp BHMT2_HUMAN 35.276 326 184 8 30 345 9 317 2.88E-51 178 BHMT2_HUMAN reviewed S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 Homo sapiens (Human) 363 L-methionine salvage [GO:0071267]; S-adenosylmethionine metabolic process [GO:0046500]; S-methylmethionine metabolic process [GO:0033477]; sulfur amino acid metabolic process [GO:0000096] GO:0000096; GO:0005829; GO:0008270; GO:0033477; GO:0046500; GO:0061627; GO:0070062; GO:0071267 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. 0 0 PF02574; Q9LZK5 CHOYP_RS27L.2.4 m.13064 sp DNJ19_ARATH 34.043 94 54 1 29 114 3 96 2.88E-10 63.9 DNJ19_ARATH reviewed DnaJ protein ERDJ3B (Chaperone protein dnaJ 19) (AtDjB19) (AtJ19) (Endoplasmic reticulum dnaJ domain-containing protein 3B) (AtERdj3B) (Protein SCJ1 homolog ERDJ3B) ERDJ3B B19 At3g62600 F26K9.30 Arabidopsis thaliana (Mouse-ear cress) 346 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response [GO:0052033]; protein folding [GO:0006457] GO:0005783; GO:0005788; GO:0005886; GO:0006457; GO:0052033 0 0 cd06257; PF00226;PF01556; Q9UBS8 CHOYP_LOC100375328.1.1 m.62160 sp RNF14_HUMAN 45.57 474 222 7 2 447 3 468 2.88E-137 405 RNF14_HUMAN reviewed E3 ubiquitin-protein ligase RNF14 (EC 6.3.2.-) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) (Triad2 protein) RNF14 ARA54 HRIHFB2038 Homo sapiens (Human) 474 "androgen receptor signaling pathway [GO:0030521]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription, DNA-templated [GO:0045893]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000209; GO:0003713; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006357; GO:0007165; GO:0008270; GO:0016567; GO:0016874; GO:0019787; GO:0030521; GO:0031624; GO:0032436; GO:0042787; GO:0045893; GO:0050681; GO:0060765; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485;PF05773; Q9WV92 CHOYP_41.3.3 m.44367 sp E41L3_MOUSE 57.637 347 141 4 56 401 113 454 2.88E-135 427 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; A0JM23 CHOYP_INSI2.1.1 m.59454 sp NPHP3_XENTR 24.766 214 145 4 5 204 1082 1293 2.89E-08 59.7 NPHP3_XENTR reviewed Nephrocystin-3 nphp3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1311 "cilium morphogenesis [GO:0060271]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; Wnt signaling pathway [GO:0016055]" GO:0005929; GO:0016055; GO:0060271; GO:0072372; GO:0090090; GO:2000095 0 0 0 PF13176; A4IF63 CHOYP_BRAFLDRAFT_87306.3.4 m.23955 sp TRIM2_BOVIN 28.455 123 83 3 134 252 622 743 2.89E-08 58.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6BM72 CHOYP_BRAFLDRAFT_224574.3.18 m.20799 sp MEG11_HUMAN 40.65 123 59 6 38 155 228 341 2.89E-15 75.1 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; F7D3V9 CHOYP_PHUM_PHUM061060.1.1 m.1693 sp LGR5_XENTR 33.879 856 505 7 23 875 29 826 2.89E-144 463 LGR5_XENTR reviewed Leucine-rich repeat-containing G-protein coupled receptor 5 lgr5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 902 G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of canonical Wnt signaling pathway [GO:0090263] GO:0004888; GO:0005887; GO:0007186; GO:0032588; GO:0090263 0 0 0 PF13855; G5EBR3 CHOYP_LOC100533289.3.6 m.27843 sp GLUCL_CAEEL 28.272 382 228 6 36 374 76 454 2.89E-48 172 GLUCL_CAEEL reviewed Glutamate-gated chloride channel alpha (Avermectin-sensitive glutamate-gated chloride channel GluCl alpha) (GluCl alpha) glc-1 F11A5.10 Caenorhabditis elegans 461 chloride transmembrane transport [GO:1902476]; locomotion involved in locomotory behavior [GO:0031987]; protein oligomerization [GO:0051259] GO:0005887; GO:0008068; GO:0016595; GO:0030054; GO:0031987; GO:0045211; GO:0051259; GO:1902476 0 0 0 PF02931;PF02932; O00370 CHOYP_LOC100536107.1.2 m.21299 sp LORF2_HUMAN 29.078 282 196 3 7 286 595 874 2.89E-28 120 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O54873 CHOYP_AIMP1.1.1 m.16360 sp AIMP1_CRIGR 48.101 316 152 4 5 316 52 359 2.89E-92 281 AIMP1_CRIGR reviewed Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)] AIMP1 SCYE1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 359 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; glucose metabolic process [GO:0006006]; inflammatory response [GO:0006954]; translation [GO:0006412] GO:0000049; GO:0001525; GO:0005615; GO:0005634; GO:0005783; GO:0005794; GO:0005829; GO:0006006; GO:0006412; GO:0006915; GO:0006954; GO:0007155; GO:0030133 0 0 0 PF01588; O70277 CHOYP_LOC100891477.1.1 m.20456 sp TRIM3_RAT 30.657 137 89 3 52 186 110 242 2.89E-08 60.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P21329 CHOYP_LOC100561123.13.28 m.13063 sp RTJK_DROFU 24.841 314 193 12 3 295 541 832 2.89E-15 82.4 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P83088 CHOYP_FUCTA.1.4 m.9618 sp FUCTC_DROME 29.315 365 207 16 63 387 64 417 2.89E-35 137 FUCTC_DROME reviewed "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) 425 protein glycosylation [GO:0006486] GO:0006486; GO:0008417; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q06033 CHOYP_BRAFLDRAFT_215239.1.3 m.1232 sp ITIH3_HUMAN 35.367 885 512 22 37 901 44 888 2.89E-156 484 ITIH3_HUMAN reviewed Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH3 Homo sapiens (Human) 890 hyaluronan metabolic process [GO:0030212]; platelet degranulation [GO:0002576] GO:0002576; GO:0004866; GO:0004867; GO:0005576; GO:0030212; GO:0031089; GO:0070062 0 0 0 PF06668;PF08487;PF00092; Q15155 CHOYP_NOMO1.1.2 m.22715 sp NOMO1_HUMAN 43.949 157 88 0 2 158 351 507 2.89E-39 144 NOMO1_HUMAN reviewed Nodal modulator 1 (pM5 protein) NOMO1 PM5 Homo sapiens (Human) 1222 0 GO:0016020; GO:0016021; GO:0030246 0 0 0 0 Q27433 CHOYP_MEC2.4.4 m.63678 sp MEC2_CAEEL 65.357 280 97 0 3 282 90 369 2.89E-128 376 MEC2_CAEEL reviewed Mechanosensory protein 2 mec-2 F14D12.4 Caenorhabditis elegans 481 mechanosensory behavior [GO:0007638]; response to mechanical stimulus [GO:0009612] GO:0007638; GO:0009612; GO:0015485; GO:0016021; GO:0032589; GO:0043005 0 0 0 PF01145; Q3UHX9 CHOYP_CI114.1.1 m.19106 sp CI114_MOUSE 60 360 135 4 46 399 17 373 2.89E-148 428 CI114_MOUSE reviewed Putative methyltransferase C9orf114 homolog (EC 2.1.1.-) D2Wsu81e Mus musculus (Mouse) 385 cell cycle [GO:0007049]; cell division [GO:0051301] GO:0000777; GO:0007049; GO:0008168; GO:0044822; GO:0051301 0 0 0 PF02598; Q5G267 CHOYP_LOC610335.1.1 m.42552 sp NETR_MACMU 46.396 222 104 3 796 1011 279 491 2.89E-56 214 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5R611 CHOYP_BRAFLDRAFT_119296.7.16 m.30417 sp HRSL3_PONAB 31.928 166 97 4 11 168 2 159 2.89E-21 87.8 HRSL3_PONAB reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) PLA2G16 HRASLS3 HREV107 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 162 lipid catabolic process [GO:0016042] GO:0004623; GO:0008970; GO:0016021; GO:0016042; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; Q60HD2 CHOYP_ATLA2.1.2 m.49539 sp ATLA1_MACFA 39.573 422 235 9 27 442 24 431 2.89E-101 317 ATLA1_MACFA reviewed Atlastin-1 (EC 3.6.5.-) ATL1 QflA-10403 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; protein homooligomerization [GO:0051260] GO:0000137; GO:0000139; GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0005794; GO:0007029; GO:0007409; GO:0016021; GO:0030424; GO:0042802; GO:0051260 0 0 0 PF02263; Q7M3S9 CHOYP_BRAFLDRAFT_203130.1.1 m.40112 sp RNGB_DICDI 37.313 67 40 1 69 135 878 942 2.89E-06 48.5 RNGB_DICDI reviewed RING finger protein B (Protein rngB) rngB DDB_G0268860 Dictyostelium discoideum (Slime mold) 943 0 GO:0005737; GO:0008270 0 0 0 PF01344; Q7SYC9 CHOYP_CTL4.1.1 m.60609 sp CTL2_DANRE 35.366 246 136 5 7 245 2 231 2.89E-45 164 CTL2_DANRE reviewed Choline transporter-like protein 2 (Solute carrier family 44 member 2) slc44a2 ctl2 zgc:63569 Danio rerio (Zebrafish) (Brachydanio rerio) 697 0 GO:0016021 0 0 0 PF04515; Q8IT98 CHOYP_RS18.3.11 m.19759 sp RS18_ARGIR 90.654 107 10 0 1 107 42 148 2.89E-70 210 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8IWW6 CHOYP_RHG12.1.2 m.15932 sp RHG12_HUMAN 32.417 873 470 29 30 831 21 844 2.89E-110 360 RHG12_HUMAN reviewed Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) ARHGAP12 Homo sapiens (Human) 846 morphogenesis of an epithelial sheet [GO:0002011]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0002011; GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00169;PF00620;PF14604; Q8Q0U0 CHOYP_SMP_166010.1.1 m.40671 sp Y045_METMA 31.228 285 188 4 56 339 74 351 2.89E-27 114 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q923L3 CHOYP_LOC100498354.1.1 m.58864 sp CSMD1_MOUSE 29.63 162 104 4 19 177 2734 2888 2.89E-18 85.1 CSMD1_MOUSE reviewed CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) Csmd1 Mus musculus (Mouse) 3564 glucose homeostasis [GO:0042593]; startle response [GO:0001964] GO:0001964; GO:0016021; GO:0042593 0 0 0 PF00431;PF00084; Q969R8 CHOYP_ITFG2.1.1 m.6319 sp ITFG2_HUMAN 46.279 430 207 8 22 428 2 430 2.89E-128 381 ITFG2_HUMAN reviewed Integrin-alpha FG-GAP repeat-containing protein 2 ITFG2 Homo sapiens (Human) 447 germinal center B cell differentiation [GO:0002314] GO:0002314; GO:0005654; GO:0005829 0 0 0 PF15907; Q96LI9 CHOYP_LOC100377974.1.1 m.6543 sp CX058_HUMAN 41.414 297 169 3 88 384 35 326 2.89E-76 243 CX058_HUMAN reviewed Putative uncharacterized protein CXorf58 CXorf58 Homo sapiens (Human) 332 0 0 0 0 0 0 Q9D032 CHOYP_SSDP.1.1 m.47616 sp SSBP3_MOUSE 54.567 416 109 19 10 400 1 361 2.89E-82 261 SSBP3_MOUSE reviewed Single-stranded DNA-binding protein 3 (Lck-associated signal transducer) (Sequence-specific single-stranded-DNA-binding protein) Ssbp3 Last Ssdp1 Mus musculus (Mouse) 388 "head development [GO:0060322]; head morphogenesis [GO:0060323]; hematopoietic progenitor cell differentiation [GO:0002244]; midbrain-hindbrain boundary initiation [GO:0021547]; positive regulation of anterior head development [GO:2000744]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; prechordal plate formation [GO:0021501]; protein complex assembly [GO:0006461]; transcription, DNA-templated [GO:0006351]" GO:0002244; GO:0003697; GO:0005634; GO:0006351; GO:0006461; GO:0008284; GO:0021501; GO:0021547; GO:0043234; GO:0045893; GO:0045944; GO:0060322; GO:0060323; GO:2000744 0 0 0 0 Q9DA42 CHOYP_LOC577148.1.1 m.56345 sp CT085_MOUSE 39.416 137 80 3 1 136 1 135 2.89E-26 98.6 CT085_MOUSE reviewed Uncharacterized protein C20orf85 homolog 0 Mus musculus (Mouse) 136 0 0 0 0 0 PF14945; Q9U943 CHOYP_APLP.2.2 m.55987 sp APLP_LOCMI 30.035 1142 708 26 22 1106 9 1116 2.89E-130 468 APLP_LOCMI reviewed Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] 0 Locusta migratoria (Migratory locust) 3380 Wnt signaling pathway [GO:0016055] GO:0005319; GO:0005576; GO:0008289; GO:0016055 0 0 0 PF08742;PF06448;PF09172;PF01347;PF00094; A5PLI4 CHOYP_LOC100371209.1.1 m.49090 sp LR2BP_DANRE 47.826 345 178 2 39 383 1 343 2.90E-108 324 LR2BP_DANRE reviewed LRP2-binding protein lrp2bp zgc:165631 Danio rerio (Zebrafish) (Brachydanio rerio) 343 0 GO:0005737 0 0 0 PF08238; D2GXS7 CHOYP_BRAFLDRAFT_87287.1.1 m.32598 sp TRIM2_AILME 23.451 226 158 6 63 280 488 706 2.90E-08 58.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZVM4 CHOYP_BRAFLDRAFT_93989.5.5 m.64715 sp LIN41_RAT 20.313 576 343 20 15 492 199 756 2.90E-08 60.1 LIN41_RAT reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) Trim71 Lin41 Rattus norvegicus (Rat) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; E1BD59 CHOYP_LOC100368204.1.3 m.13 sp TRI56_BOVIN 22.403 308 198 10 9 289 1 294 2.90E-12 73.6 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; H2A0M7 CHOYP_PLSP.3.5 m.43196 sp PLSP_PINMG 41.609 721 369 21 7 694 8 709 2.90E-135 424 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O75095 CHOYP_MEGF6.54.59 m.57464 sp MEGF6_HUMAN 41.935 62 32 2 36 97 567 624 2.90E-07 56.2 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O88801 CHOYP_HOMER2.1.1 m.43723 sp HOME2_RAT 70.543 129 37 1 23 150 3 131 2.90E-62 197 HOME2_RAT reviewed Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2) Homer2 Vesl2 Rattus norvegicus (Rat) 354 sensory perception of sound [GO:0007605] GO:0005730; GO:0005737; GO:0007605; GO:0014069; GO:0019904; GO:0030054; GO:0030425; GO:0032426; GO:0035254; GO:0035256; GO:0042803; GO:0043025; GO:0045211; GO:0046982 0 0 0 PF00568; P20273 CHOYP_LOC100880815.3.7 m.45911 sp CD22_HUMAN 25.941 478 289 22 18 470 257 694 2.90E-24 112 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P32542 CHOYP_CBG17454.1.2 m.13847 sp POL_EIAVC 26.935 323 190 13 332 640 215 505 2.90E-11 71.6 POL_EIAVC reviewed Pol polyprotein [Cleaved into: Protease (Retropepsin) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Equine infectious anemia virus (isolate CL22) (EIAV) 1146 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; dUTP metabolic process [GO:0046080]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003964; GO:0004190; GO:0004523; GO:0004533; GO:0006310; GO:0008270; GO:0015074; GO:0046080; GO:0046718; GO:0075713 0 0 cd07557; PF00692;PF00552;PF02022;PF00075;PF00665;PF00077;PF00078;PF06815;PF06817; P34088 CHOYP_RAG1.1.1 m.49203 sp RAG1_RABIT 29.008 131 67 5 20 128 102 228 2.90E-06 50.8 RAG1_RABIT reviewed V(D)J recombination-activating protein 1 (RAG-1) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 6.3.2.-)] RAG1 Oryctolagus cuniculus (Rabbit) 1042 B cell differentiation [GO:0030183]; histone monoubiquitination [GO:0010390]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; T cell differentiation in thymus [GO:0033077]; V(D)J recombination [GO:0033151] GO:0002331; GO:0004519; GO:0004842; GO:0005634; GO:0008270; GO:0010390; GO:0016874; GO:0030183; GO:0033077; GO:0033151; GO:0042393; GO:0042803; GO:0043565; GO:0046872; GO:0051865; GO:0061630 0 0 0 PF12940;PF10426; P49582 CHOYP_ACHD.2.2 m.51507 sp ACHA7_MOUSE 27.703 296 202 6 32 320 29 319 2.90E-32 130 ACHA7_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-7 Chrna7 Acra7 Mus musculus (Mouse) 502 "activation of MAPK activity [GO:0000187]; associative learning [GO:0008306]; B cell activation [GO:0042113]; behavioral response to ethanol [GO:0048149]; behavioral response to nicotine [GO:0035095]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; cognition [GO:0050890]; endocytosis [GO:0006897]; generation of ovulation cycle rhythm [GO:0060112]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; memory [GO:0007613]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; ovulation cycle [GO:0042698]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure [GO:0001988]; regulation of inflammatory response [GO:0050727]; regulation of membrane potential [GO:0042391]; regulation of norepinephrine secretion [GO:0014061]; regulation of synaptic transmission, dopaminergic [GO:0032225]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; sperm motility [GO:0030317]; synaptic transmission, cholinergic [GO:0007271]; T cell activation [GO:0042110]" GO:0000187; GO:0001540; GO:0001666; GO:0001988; GO:0004889; GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0006874; GO:0006897; GO:0007165; GO:0007271; GO:0007613; GO:0008284; GO:0008306; GO:0009897; GO:0014061; GO:0015464; GO:0015643; GO:0016020; GO:0016324; GO:0017081; GO:0022848; GO:0030054; GO:0030317; GO:0030673; GO:0032094; GO:0032225; GO:0032691; GO:0032715; GO:0032720; GO:0034220; GO:0035094; GO:0035095; GO:0042110; GO:0042113; GO:0042166; GO:0042391; GO:0042698; GO:0042803; GO:0045211; GO:0045471; GO:0045766; GO:0048149; GO:0050727; GO:0050728; GO:0050890; GO:0060112 0 0 0 PF02931;PF02932; P49614 CHOYP_HEXB.1.1 m.9750 sp HEXB_FELCA 50.307 163 80 1 1 163 368 529 2.90E-53 179 HEXB_FELCA reviewed Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (N-acetyl-beta-glucosaminidase subunit beta) HEXB Felis catus (Cat) (Felis silvestris catus) 531 carbohydrate metabolic process [GO:0005975] GO:0004563; GO:0005764; GO:0005975 0 0 0 PF00728;PF14845; P80311 CHOYP_DVIR_GJ21252.1.1 m.10086 sp PPIB_BOVIN 68.72 211 56 3 1 206 11 216 2.90E-96 282 PPIB_BOVIN reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Bos taurus (Bovine) 216 bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of multicellular organism growth [GO:0040018]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821] GO:0000413; GO:0003755; GO:0005634; GO:0005788; GO:0005925; GO:0016020; GO:0032403; GO:0032991; GO:0034663; GO:0040018; GO:0042277; GO:0042470; GO:0044822; GO:0044829; GO:0048471; GO:0050821; GO:0060348; GO:0061077; GO:0070062 0 0 0 PF00160; Q01415 CHOYP_GALK2.2.2 m.23258 sp GALK2_HUMAN 57.798 109 45 1 2 110 90 197 2.90E-32 120 GALK2_HUMAN reviewed N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2) GALK2 GK2 Homo sapiens (Human) 458 carbohydrate metabolic process [GO:0005975]; galactose metabolic process [GO:0006012] GO:0004335; GO:0005524; GO:0005737; GO:0005975; GO:0006012; GO:0033858 0 0 0 PF10509;PF08544;PF00288; Q05793 CHOYP_PHUM_PHUM498630.1.3 m.6781 sp PGBM_MOUSE 31.285 179 110 2 199 377 3233 3398 2.90E-21 99.8 PGBM_MOUSE reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) [Cleaved into: Endorepellin; LG3 peptide] Hspg2 Mus musculus (Mouse) 3707 angiogenesis [GO:0001525]; brain development [GO:0007420]; cardiac muscle tissue development [GO:0048738]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; chondrocyte differentiation [GO:0002062]; embryonic skeletal system morphogenesis [GO:0048704]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; protein localization [GO:0008104] GO:0001525; GO:0001958; GO:0002020; GO:0002062; GO:0005509; GO:0005576; GO:0005578; GO:0005604; GO:0005605; GO:0005615; GO:0005796; GO:0005925; GO:0006024; GO:0007420; GO:0008022; GO:0008104; GO:0030198; GO:0031012; GO:0048704; GO:0048738; GO:0060351; GO:0070062 0 0 0 PF00008;PF07679;PF00052;PF00053;PF00054;PF00057; Q05A13 CHOYP_LOC100556847.1.1 m.40539 sp S16C6_MOUSE 54.404 193 79 4 5 193 1 188 2.90E-66 209 S16C6_MOUSE reviewed Short-chain dehydrogenase/reductase family 16C member 6 (EC 1.1.1.-) Sdr16c6 Mus musculus (Mouse) 316 0 GO:0016491 0 0 0 PF00106; Q0P5D1 CHOYP_LOC100177979.1.2 m.31024 sp CC153_BOVIN 28.902 173 114 3 1 167 1 170 2.90E-13 68.2 CC153_BOVIN reviewed Coiled-coil domain-containing protein 153 CCDC153 Bos taurus (Bovine) 204 0 0 0 0 0 0 Q1LWJ6 CHOYP_LOC100373090.1.1 m.52283 sp ARPIN_DANRE 50.655 229 107 2 25 250 1 226 2.90E-73 225 ARPIN_DANRE reviewed Arpin arpin zgc:112432 Danio rerio (Zebrafish) (Brachydanio rerio) 226 directional locomotion [GO:0033058]; negative regulation of cell migration [GO:0030336] GO:0030027; GO:0030336; GO:0033058 0 0 0 PF10574; Q3SXM5 CHOYP_LOC100371253.1.1 m.16290 sp HSDL1_HUMAN 52.615 325 154 0 5 329 1 325 2.90E-127 370 HSDL1_HUMAN reviewed Inactive hydroxysteroid dehydrogenase-like protein 1 (Short chain dehydrogenase/reductase family 12C member 3) HSDL1 SDR12C3 Homo sapiens (Human) 330 0 GO:0005739 0 0 0 PF00106; Q4ZJM9 CHOYP_C1QL4.4.10 m.27527 sp C1QL4_MOUSE 33.333 141 77 6 155 293 110 235 2.90E-07 53.9 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q51330 CHOYP_LOC585136.1.1 m.31968 sp OXLT_OXAFO 21.662 397 263 4 61 457 45 393 2.90E-18 90.1 OXLT_OXAFO reviewed Oxalate:formate antiporter (OFA) (Oxalate:formate antiport protein) (Oxalate:formate exchange protein) oxlT Oxalobacter formigenes 418 ion transport [GO:0006811] GO:0005886; GO:0006811; GO:0015297; GO:0016021 0 0 cd06174; PF07690; Q58D94 CHOYP_TALDO.2.2 m.43332 sp MKNK1_BOVIN 51.707 205 83 3 1 204 210 399 2.90E-66 213 MKNK1_BOVIN reviewed MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) MKNK1 Bos taurus (Bovine) 420 intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; regulation of translation [GO:0006417] GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006417; GO:0009931; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF00069; Q5HZZ6 CHOYP_MED8B.1.1 m.7004 sp MED8A_XENLA 47.794 272 114 4 2 249 1 268 2.90E-73 227 MED8A_XENLA reviewed Mediator of RNA polymerase II transcription subunit 8-A (Mediator complex subunit 8-A) med8-a Xenopus laevis (African clawed frog) 268 "protein ubiquitination [GO:0016567]; transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016567; GO:0016592 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF10232; Q5I0P2 CHOYP_RTTN.1.3 m.9026 sp GCSH_RAT 58.333 132 55 0 32 163 36 167 2.90E-50 162 GCSH_RAT reviewed "Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)" Gcsh Rattus norvegicus (Rat) 170 glycine decarboxylation via glycine cleavage system [GO:0019464] GO:0004047; GO:0005739; GO:0005960; GO:0019464; GO:0019899 0 0 cd06848; 0 Q63072 CHOYP_BST1.1.1 m.5015 sp BST1_RAT 29.134 254 169 6 24 276 48 291 2.90E-29 116 BST1_RAT reviewed ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPr hydrolase 2) (CD antigen CD157) Bst1 Rattus norvegicus (Rat) 319 positive regulation of B cell proliferation [GO:0030890] GO:0003953; GO:0005886; GO:0016740; GO:0016849; GO:0030890; GO:0031225; GO:0050135 0 0 0 PF02267; Q68CP4 CHOYP_HGSNAT.1.2 m.32165 sp HGNAT_HUMAN 38.721 594 317 15 75 648 94 660 2.90E-125 388 HGNAT_HUMAN reviewed Heparan-alpha-glucosaminide N-acetyltransferase (EC 2.3.1.78) (Transmembrane protein 76) HGSNAT TMEM76 Homo sapiens (Human) 663 glycosaminoglycan catabolic process [GO:0006027]; lysosomal transport [GO:0007041]; protein oligomerization [GO:0051259] GO:0005765; GO:0006027; GO:0007041; GO:0015019; GO:0016021; GO:0016746; GO:0051259 0 0 0 PF07786; Q6AXS9 CHOYP_FAM101B.1.1 m.29700 sp F101B_RAT 27.132 129 93 1 1 129 87 214 2.90E-09 57.8 F101B_RAT reviewed Filamin-interacting protein FAM101B (Protein FAM101B) (Regulator of filamin protein B) (RefilinB) Fam101b Rattus norvegicus (Rat) 216 actin filament bundle organization [GO:0061572]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte development [GO:0061182]; skeletal system morphogenesis [GO:0048705] GO:0001837; GO:0005737; GO:0032432; GO:0048705; GO:0061182; GO:0061572; GO:1900158 0 0 0 PF15068; Q6AYR2 CHOYP_LOC413005.1.1 m.63172 sp NDRG3_RAT 44.282 341 162 6 16 351 1 318 2.90E-87 271 NDRG3_RAT reviewed Protein NDRG3 (N-myc downstream-regulated gene 3 protein) Ndrg3 Ndr3 Rattus norvegicus (Rat) 375 signal transduction [GO:0007165] GO:0005737; GO:0007165 0 0 0 PF03096; Q6P1D7 CHOYP_PABP4.3.6 m.35372 sp SLX4_MOUSE 31.858 226 119 6 257 447 1328 1553 2.90E-22 103 SLX4_MOUSE reviewed Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12) Slx4 Btbd12 Mus musculus (Mouse) 1565 DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; nucleotide-excision repair [GO:0006289]; positive regulation of t-circle formation [GO:1904431]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; t-circle formation [GO:0090656] GO:0000724; GO:0000784; GO:0000790; GO:0005654; GO:0005737; GO:0006260; GO:0006281; GO:0006289; GO:0008047; GO:0008821; GO:0010792; GO:0017108; GO:0030054; GO:0033557; GO:0048257; GO:0048476; GO:0070522; GO:0072429; GO:0090656; GO:1904431 0 0 0 PF00651;PF09494; Q7YQK3 CHOYP_SLC31.4.5 m.43503 sp 4F2_RABIT 36 125 65 3 39 162 61 171 2.90E-19 90.9 4F2_RABIT reviewed 4F2 cell-surface antigen heavy chain (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98) SLC3A2 Oryctolagus cuniculus (Rabbit) 529 carbohydrate metabolic process [GO:0005975]; leucine import [GO:0060356]; tryptophan transport [GO:0015827] GO:0003824; GO:0005975; GO:0015175; GO:0015827; GO:0016021; GO:0016324; GO:0042470; GO:0060356 0 0 0 PF00128;PF16028; Q7ZV68 CHOYP_VPS29.1.1 m.3627 sp VPS29_DANRE 87.912 182 22 0 25 206 1 182 2.90E-122 346 VPS29_DANRE reviewed Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29) vps29 zK83d9.2-001 Danio rerio (Zebrafish) (Brachydanio rerio) 182 "intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005768; GO:0005829; GO:0006886; GO:0010008; GO:0030904; GO:0042147; GO:0046872 0 0 0 PF12850; Q8C8V1 CHOYP_LOC100366838.1.1 m.22440 sp ZXDC_MOUSE 47.078 308 149 5 427 726 176 477 2.90E-91 313 ZXDC_MOUSE reviewed Zinc finger protein ZXDC Zxdc Mus musculus (Mouse) 858 "positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0003700; GO:0005634; GO:0006351; GO:0030275; GO:0045893; GO:0046872; GO:0070742 0 0 0 0 Q8K2Y0 CHOYP_RN219.1.3 m.10641 sp RN219_MOUSE 46.748 246 121 2 14 249 9 254 2.90E-65 237 RN219_MOUSE reviewed RING finger protein 219 Rnf219 Mus musculus (Mouse) 722 "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" GO:0008270; GO:0048026 0 0 0 0 Q8YA32 CHOYP_LOC100890653.1.1 m.13755 sp INLI_LISMO 26.301 346 207 14 525 859 314 622 2.90E-09 65.1 INLI_LISMO reviewed Internalin-I inlI lmo0333 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) 1778 0 GO:0005576; GO:0005618 0 0 0 PF12799;PF13855;PF08191;PF06458; Q92752 CHOYP_FGL2.4.9 m.51501 sp TENR_HUMAN 46.33 218 108 7 85 298 1130 1342 2.90E-54 193 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q96DY2 CHOYP_LOC100376807.1.1 m.22568 sp IQCD_HUMAN 37.011 435 228 7 46 478 32 422 2.90E-78 254 IQCD_HUMAN reviewed IQ domain-containing protein D IQCD Homo sapiens (Human) 449 0 0 0 0 0 PF00612; Q96MM6 CHOYP_LOC100899882.1.3 m.27725 sp HS12B_HUMAN 28.771 643 378 14 40 620 61 685 2.90E-91 299 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99M80 CHOYP_PTPRE.6.19 m.28070 sp PTPRT_MOUSE 30.069 725 441 16 408 1097 760 1453 2.90E-85 306 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9CWU9 CHOYP_BRAFLDRAFT_114714.1.1 m.36377 sp NUP37_MOUSE 38.08 323 187 6 10 327 9 323 2.90E-70 224 NUP37_MOUSE reviewed Nucleoporin Nup37 (Nup107-160 subcomplex subunit Nup37) Nup37 Mus musculus (Mouse) 326 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; mRNA transport [GO:0051028]; protein transport [GO:0015031] GO:0000777; GO:0005634; GO:0005654; GO:0007059; GO:0007067; GO:0015031; GO:0031080; GO:0051028; GO:0051301 0 0 0 PF00400; Q9CZ15 CHOYP_BRAFLDRAFT_120278.2.2 m.33989 sp PSF1_MOUSE 60.317 126 49 1 33 157 26 151 2.90E-52 167 PSF1_MOUSE reviewed DNA replication complex GINS protein PSF1 (GINS complex subunit 1) Gins1 Psf1 Mus musculus (Mouse) 196 DNA replication [GO:0006260]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; inner cell mass cell proliferation [GO:0001833] GO:0000811; GO:0001833; GO:0005634; GO:0005737; GO:0006260; GO:0043138; GO:1902983 0 0 cd11710; 0 Q9HAR2 CHOYP_LPLT1.1.1 m.21953 sp AGRL3_HUMAN 30.101 691 400 22 269 903 483 1146 2.90E-69 256 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9MYW3 CHOYP_TLR4.2.4 m.37154 sp TLR4_HORSE 35.928 167 90 7 319 469 676 841 2.90E-21 101 TLR4_HORSE reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Equus caballus (Horse) 843 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0001530; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005887; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13516;PF13855;PF01582; Q9UIF8 CHOYP_BRAFLDRAFT_122791.4.6 m.14388 sp BAZ2B_HUMAN 40.748 535 277 10 550 1047 731 1262 2.90E-107 387 BAZ2B_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00439;PF02791;PF01429;PF00628;PF15613; Q9UJT9 CHOYP_FBXL7.2.3 m.14083 sp FBXL7_HUMAN 51.807 166 80 0 226 391 114 279 2.90E-55 192 FBXL7_HUMAN reviewed F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) 491 cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000086; GO:0000151; GO:0004842; GO:0005737; GO:0005813; GO:0006511; GO:0007067; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q9VFB2 CHOYP_RT10.1.4 m.2099 sp RT10_DROME 45.89 146 72 2 55 195 25 168 2.90E-36 134 RT10_DROME reviewed "28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt)" mRpS10 CG4247 Drosophila melanogaster (Fruit fly) 173 sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005763; GO:0006412; GO:0019233 0 0 0 PF00338; Q9VXE5 CHOYP_ISCW_ISCW022207.1.1 m.22824 sp PAKM_DROME 77.143 105 24 0 13 117 535 639 2.90E-50 171 PAKM_DROME reviewed Serine/threonine-protein kinase PAK mbt (EC 2.7.11.1) (Protein mushroom bodies tiny) (p21-activated kinase-related protein) mbt CG18582 Drosophila melanogaster (Fruit fly) 639 activation of MAPK activity [GO:0000187]; compound eye development [GO:0048749]; compound eye photoreceptor cell differentiation [GO:0001751]; cytoskeleton organization [GO:0007010]; Golgi organization [GO:0007030]; lateral inhibition [GO:0046331]; mushroom body development [GO:0016319]; negative regulation of cell size [GO:0045792]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of compound eye photoreceptor development [GO:0045315]; protein phosphorylation [GO:0006468]; regulation of cell-cell adhesion mediated by cadherin [GO:2000047] GO:0000187; GO:0001751; GO:0004672; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005886; GO:0005912; GO:0005913; GO:0006468; GO:0007010; GO:0007030; GO:0016319; GO:0017048; GO:0018105; GO:0045315; GO:0045792; GO:0046331; GO:0048749; GO:2000047 0 0 0 PF00786;PF00069; Q9Y3Z3 CHOYP_SAMH1.10.12 m.55275 sp SAMH1_HUMAN 55.159 504 208 7 515 1004 116 615 2.90E-178 536 SAMH1_HUMAN reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) SAMHD1 MOP5 Homo sapiens (Human) 626 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; immune response [GO:0006955]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; type I interferon signaling pathway [GO:0060337] GO:0003676; GO:0003723; GO:0005622; GO:0005634; GO:0005654; GO:0005886; GO:0006203; GO:0006955; GO:0008270; GO:0008832; GO:0032567; GO:0045088; GO:0046061; GO:0051289; GO:0051607; GO:0060337 0 0 0 PF01966;PF07647; A4IF63 CHOYP_contig_041290 m.47084 sp TRIM2_BOVIN 31.481 108 68 4 41 145 627 731 2.91E-06 49.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; I1VZH0 CHOYP_BRAFLDRAFT_117133.2.2 m.63232 sp RN207_RABIT 23.153 203 141 6 1 201 105 294 2.91E-09 61.2 RN207_RABIT reviewed RING finger protein 207 RNF207 Oryctolagus cuniculus (Rabbit) 594 0 GO:0005737; GO:0008270 0 0 0 PF00643; O00468 CHOYP_AGRIN.5.5 m.63560 sp AGRIN_HUMAN 55.682 88 35 2 13 98 1969 2054 2.91E-24 99.4 AGRIN_HUMAN reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Homo sapiens (Human) 2067 clustering of voltage-gated sodium channels [GO:0045162]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0001523; GO:0002162; GO:0005200; GO:0005509; GO:0005576; GO:0005605; GO:0005737; GO:0005796; GO:0005886; GO:0006024; GO:0006027; GO:0007165; GO:0007213; GO:0016021; GO:0030054; GO:0030198; GO:0030203; GO:0031012; GO:0033691; GO:0035374; GO:0043113; GO:0043202; GO:0043236; GO:0043395; GO:0043547; GO:0045162; GO:0045202; GO:0045887; GO:0045944; GO:0050808; GO:0051491; GO:0070062 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF03146;PF01390; O02827 CHOYP_TITIN.1.19 m.2117 sp MYLK_SHEEP 36.607 112 70 1 384 495 311 421 2.91E-15 82.4 MYLK_SHEEP reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] (Fragment)" MYLK Ovis aries (Sheep) 438 0 GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0030027; GO:0032154; GO:0046872 0 0 0 PF07679;PF00069; O18334 CHOYP_LOC100178081.1.1 m.56365 sp RAB6_DROME 88.462 208 22 2 3 209 2 208 2.91E-133 375 RAB6_DROME reviewed Ras-related protein Rab6 (Protein warthog) Rab6 wrt CG6601 Drosophila melanogaster (Fruit fly) 208 "axon guidance [GO:0007411]; compound eye morphogenesis [GO:0001745]; defense response to fungus [GO:0050832]; exocytosis [GO:0006887]; germarium-derived egg chamber formation [GO:0007293]; intra-Golgi vesicle-mediated transport [GO:0006891]; oocyte microtubule cytoskeleton polarization [GO:0008103]; photoreceptor cell maintenance [GO:0045494]; phototransduction [GO:0007602]; pole plasm oskar mRNA localization [GO:0045451]; R7 cell development [GO:0045467]; Rab protein signal transduction [GO:0032482]; regulation of postsynaptic membrane potential [GO:0060078]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle-mediated transport [GO:0016192]" GO:0000139; GO:0001745; GO:0003924; GO:0005525; GO:0005794; GO:0005829; GO:0006887; GO:0006890; GO:0006891; GO:0007293; GO:0007411; GO:0007602; GO:0008103; GO:0016023; GO:0016192; GO:0030054; GO:0031982; GO:0032482; GO:0042147; GO:0043025; GO:0043204; GO:0045202; GO:0045451; GO:0045467; GO:0045494; GO:0050832; GO:0060078 0 0 0 PF00071; O50655 CHOYP_LOC100373761.1.3 m.295 sp XERD_SELRU 24.671 304 205 8 150 442 34 324 2.91E-07 55.8 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; P0CP41 CHOYP_NUF2.1.1 m.48851 sp NUF2_CRYNB 23.274 391 249 10 7 366 14 384 2.91E-20 96.3 NUF2_CRYNB reviewed Probable kinetochore protein NUF2 NUF2 CNBA6390 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) 467 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005634; GO:0007067; GO:0051301 0 0 0 PF03800; P10079 CHOYP_TRIADDRAFT_26633.2.6 m.34479 sp FBP1_STRPU 50.524 477 236 0 378 854 214 690 2.91E-150 472 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P16035 CHOYP_TIMP2.1.3 m.38750 sp TIMP2_HUMAN 33.684 190 101 10 18 190 24 205 2.91E-18 82.4 TIMP2_HUMAN reviewed Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2) TIMP2 Homo sapiens (Human) 220 aging [GO:0007568]; central nervous system development [GO:0007417]; extracellular matrix disassembly [GO:0022617]; negative regulation of cell proliferation [GO:0008285]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron differentiation [GO:0045666]; regulation of Rap protein signal transduction [GO:0032487]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to hormone [GO:0009725] GO:0002020; GO:0005576; GO:0005578; GO:0005615; GO:0007417; GO:0007568; GO:0008191; GO:0008285; GO:0009725; GO:0009986; GO:0022617; GO:0030426; GO:0031012; GO:0032487; GO:0034097; GO:0042493; GO:0043025; GO:0043410; GO:0045666; GO:0045762; GO:0045930; GO:0046580; GO:0046872; GO:0051045; GO:0070062 0 0 0 PF00965; P21369 CHOYP_BRAFLDRAFT_84072.1.1 m.44340 sp PNCA_ECOLI 38.942 208 109 3 96 303 5 194 2.91E-40 144 PNCA_ECOLI reviewed Pyrazinamidase/nicotinamidase (PZAase) (EC 3.5.1.-) (EC 3.5.1.19) (Nicotine deamidase) (NAMase) pncA nam ydjB b1768 JW1757 Escherichia coli (strain K12) 213 NAD metabolic process [GO:0019674]; nicotinamide metabolic process [GO:0006769]; pyridine nucleotide biosynthetic process [GO:0019363] GO:0005737; GO:0005829; GO:0006769; GO:0008936; GO:0019363; GO:0019674; GO:0046872 PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1. 0 0 PF00857; P31649 CHOYP_LOAG_08466.1.1 m.58954 sp S6A13_MOUSE 24.046 603 369 26 9 587 48 585 2.91E-22 104 S6A13_MOUSE reviewed Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Sodium- and chloride-dependent GABA transporter 3) (GAT-3) (Solute carrier family 6 member 13) Slc6a13 Gabt2 Gabt3 Gat-3 Gat2 Gat3 Mus musculus (Mouse) 602 chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid transport [GO:0015812]; neurotransmitter transport [GO:0006836] GO:0005328; GO:0005332; GO:0005887; GO:0006836; GO:0007268; GO:0015812; GO:0042165; GO:0043005; GO:0070062 0 0 0 PF00209; P54145 CHOYP_LOC100313550.2.2 m.35436 sp AMT1_CAEEL 34.889 407 242 7 12 399 32 434 2.91E-66 224 AMT1_CAEEL reviewed Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans 534 ammonium transmembrane transport [GO:0072488]; nitrogen utilization [GO:0019740]; organic cation transport [GO:0015695] GO:0005887; GO:0008519; GO:0015695; GO:0019740; GO:0072488 0 0 0 PF00909; Q03601 CHOYP_BRAFLDRAFT_87279.8.10 m.46258 sp NHL1_CAEEL 30.357 112 66 4 18 120 772 880 2.91E-08 54.3 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q0PV50 CHOYP_TLR3.3.6 m.34924 sp TLR3_BOSTR 27.376 263 163 12 246 490 472 724 2.91E-08 60.5 TLR3_BOSTR reviewed Toll-like receptor 3 (CD antigen CD283) TLR3 Boselaphus tragocamelus (Nilgai) 904 defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138] GO:0002756; GO:0003725; GO:0004888; GO:0005769; GO:0005789; GO:0006954; GO:0010008; GO:0016021; GO:0032722; GO:0034138; GO:0043330; GO:0045087; GO:0050729; GO:0051607 0 0 0 PF13516;PF13855;PF01582; Q25145 CHOYP_TPM.8.19 m.19443 sp TPM_HALRU 61.635 159 61 0 8 166 125 283 2.91E-54 176 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q32KV4 CHOYP_LOC100372607.1.1 m.49009 sp DC2L1_BOVIN 49.419 344 167 2 10 347 6 348 2.91E-125 366 DC2L1_BOVIN reviewed Cytoplasmic dynein 2 light intermediate chain 1 DYNC2LI1 Bos taurus (Bovine) 351 cilium assembly [GO:0042384]; determination of left/right symmetry [GO:0007368] GO:0003774; GO:0005737; GO:0005874; GO:0005930; GO:0007368; GO:0030286; GO:0030990; GO:0031512; GO:0036064; GO:0042384; GO:0045177; GO:0045504; GO:0072372 0 0 0 PF05783; Q32L96 CHOYP_PHIPL.1.1 m.56489 sp PHIPL_BOVIN 29.452 146 87 6 168 303 112 251 2.91E-06 51.6 PHIPL_BOVIN reviewed Phytanoyl-CoA hydroxylase interacting protein-like PHYHIPL Bos taurus (Bovine) 376 0 GO:0005739 0 0 0 PF00041; Q460N5 CHOYP_PAR14.10.17 m.51485 sp PAR14_HUMAN 29.353 603 377 17 4 588 901 1472 2.91E-63 229 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_LOC100639847.1.1 m.29011 sp SVEP1_HUMAN 30.345 145 84 7 120 260 2792 2923 2.91E-06 53.1 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5EBP3 CHOYP_BRAFLDRAFT_124905.1.1 m.14920 sp ARMC5_MOUSE 27.419 310 202 7 61 355 115 416 2.91E-22 107 ARMC5_MOUSE reviewed Armadillo repeat-containing protein 5 Armc5 Mus musculus (Mouse) 926 0 GO:0005737 0 0 0 PF00651; Q5ZJL7 CHOYP_LOC100554400.1.1 m.9474 sp DDB2_CHICK 46.173 392 201 4 123 507 111 499 2.91E-121 368 DDB2_CHICK reviewed DNA damage-binding protein 2 (Damage-specific DNA-binding protein 2) DDB2 RCJMB04_17d21 Gallus gallus (Chicken) 507 histone H2A monoubiquitination [GO:0035518]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; pyrimidine dimer repair [GO:0006290]; UV-damage excision repair [GO:0070914] GO:0000209; GO:0003684; GO:0004842; GO:0005654; GO:0006290; GO:0030054; GO:0031465; GO:0035518; GO:0051865; GO:0070914 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q63ZH8 CHOYP_DGRI_GH20300.1.1 m.57587 sp F136A_XENLA 35.036 137 86 1 13 149 3 136 2.91E-25 96.7 F136A_XENLA reviewed Protein FAM136A fam136a Xenopus laevis (African clawed frog) 138 0 0 0 0 0 PF05811; Q6P1C1 CHOYP_IPPK.1.2 m.23049 sp IPPK_MOUSE 36.774 155 93 3 122 276 308 457 2.91E-22 99 IPPK_MOUSE reviewed "Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)" Ippk Mus musculus (Mouse) 489 inositol phosphate biosynthetic process [GO:0032958]; inositol phosphorylation [GO:0052746]; mitophagy in response to mitochondrial depolarization [GO:0098779] GO:0005524; GO:0005622; GO:0005634; GO:0005737; GO:0032958; GO:0035299; GO:0052746; GO:0098779 0 0 0 PF06090; Q7KM13 CHOYP_LOC100141592.1.1 m.40962 sp HEY_DROME 38.983 118 64 2 48 165 107 216 2.91E-20 96.3 HEY_DROME reviewed Hairy/enhancer-of-split related with YRPW motif protein Hey Hesr-1 CG11194 Drosophila melanogaster (Fruit fly) 425 "negative regulation of Notch signaling pathway [GO:0045746]; neuron fate determination [GO:0048664]; Notch signaling pathway [GO:0007219]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007219; GO:0045746; GO:0048664 0 0 0 PF07527;PF00010; Q7W977 CHOYP_BRAFLDRAFT_86765.1.1 m.54066 sp ECTD_BORPA 23.482 247 173 5 4 236 28 272 2.91E-13 72 ECTD_BORPA reviewed Ectoine dioxygenase (EC 1.14.11.-) (Ectoine hydroxylase) ectD BPP1891 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 308 ectoine catabolic process [GO:0042400] GO:0005506; GO:0016706; GO:0042400 0 0 0 PF05721; Q80V03 CHOYP_ADCK5.2.2 m.46507 sp ADCK5_MOUSE 51.639 366 171 1 1 360 207 572 2.91E-126 378 ADCK5_MOUSE reviewed Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-) Adck5 Mus musculus (Mouse) 582 0 GO:0004674; GO:0005739; GO:0016021 0 0 0 PF03109; Q8C6K9 CHOYP_COL6A4.2.2 m.64224 sp CO6A6_MOUSE 21.958 337 238 8 145 474 265 583 2.91E-13 76.3 CO6A6_MOUSE reviewed Collagen alpha-6(VI) chain Col6a6 Mus musculus (Mouse) 2265 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; Q8R238 CHOYP_LOC100367535.2.2 m.45982 sp SDSL_MOUSE 47.302 315 165 1 1 314 1 315 2.91E-92 280 SDSL_MOUSE reviewed Serine dehydratase-like (EC 4.3.1.17) (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (SDH) Sdsl Sds Mus musculus (Mouse) 329 0 GO:0003941; GO:0004794; GO:0005739; GO:0030170; GO:0070062 0 0 0 PF00291; Q8VDH1 CHOYP_LOC100373655.1.1 m.66117 sp FBX21_MOUSE 31.746 126 79 3 110 233 487 607 2.91E-12 68.9 FBX21_MOUSE reviewed F-box only protein 21 Fbxo21 Fbx21 Kiaa0875 Mus musculus (Mouse) 627 protein ubiquitination [GO:0016567] GO:0000151; GO:0003677; GO:0016567 0 0 0 PF13369;PF08755; Q9QXE5 CHOYP_PRSS16.1.1 m.15787 sp TSSP_MOUSE 37.374 99 60 1 13 109 195 293 2.91E-15 73.2 TSSP_MOUSE reviewed Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16) Prss16 Tssp Mus musculus (Mouse) 509 proteolysis [GO:0006508] GO:0004185; GO:0005764; GO:0005768; GO:0006508; GO:0008239; GO:0016023 0 0 0 PF05577; Q9R1R2 CHOYP_contig_017451 m.20477 sp TRIM3_MOUSE 28.333 120 83 2 63 180 625 743 2.91E-09 59.3 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UV68 CHOYP_SMB_G3331.1.1 m.3792 sp XYNC_NEOPA 40 80 47 1 307 385 350 429 2.91E-08 58.9 XYNC_NEOPA reviewed "Endo-1,4-beta-xylanase C (Xylanase C) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase C)" xynC Neocallimastix patriciarum (Rumen fungus) 485 xylan catabolic process [GO:0045493] GO:0005576; GO:0030248; GO:0031176; GO:0045493 PATHWAY: Glycan degradation; xylan degradation. 0 0 PF00734;PF00457; Q9Y493 CHOYP_PMAR_PMAR018493.1.1 m.41713 sp ZAN_HUMAN 27.119 177 126 1 22 195 838 1014 2.91E-09 60.1 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; Q9YGL1 CHOYP_LOC100488624.1.1 m.50562 sp SPD1B_XENLA 56.281 199 79 3 106 298 56 252 2.91E-68 218 SPD1B_XENLA reviewed Speedy protein 1-B (Spy1-B) (Protein Ls27) (Rapid inducer of G2/M progression in oocytes B) (RINGO-B) (XSpy1-B) (p33 ringo-B) (xRINGO-B) spdya-b ls27 spdy1 spy1 Xenopus laevis (African clawed frog) 298 activation of MAPK activity [GO:0000187]; meiotic G2/MI transition [GO:0008315]; mRNA polyadenylation [GO:0006378]; multicellular organism development [GO:0007275]; oocyte maturation [GO:0001556]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of meiotic cell cycle [GO:0051446] GO:0000187; GO:0001556; GO:0005634; GO:0006378; GO:0007275; GO:0008315; GO:0019901; GO:0030332; GO:0045737; GO:0051446 0 0 0 PF11357; A0JM12 CHOYP_BRAFLDRAFT_89663.2.2 m.43009 sp MEG10_XENTR 40 110 59 5 1 109 693 796 2.92E-12 65.1 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A0JPF9 CHOYP_LOC101160346.1.1 m.17515 sp ISPD_DANRE 51.653 242 113 1 7 244 62 303 2.92E-75 244 ISPD_DANRE reviewed Isoprenoid synthase domain-containing protein (EC 2.7.7.-) (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) ispd zgc:154151 Danio rerio (Zebrafish) (Brachydanio rerio) 462 brain morphogenesis [GO:0048854]; isoprenoid biosynthetic process [GO:0008299]; muscle fiber development [GO:0048747]; protein O-linked mannosylation [GO:0035269]; regulation of protein glycosylation [GO:0060049] GO:0008299; GO:0035269; GO:0048747; GO:0048854; GO:0050518; GO:0060049 PATHWAY: Protein modification; protein glycosylation. 0 cd02516; PF01128; A4IF63 CHOYP_BRAFLDRAFT_211053.2.2 m.53288 sp TRIM2_BOVIN 33.333 120 74 4 35 151 627 743 2.92E-09 57.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_CARNS1.6.6 m.64240 sp CRNS1_HUMAN 36.111 180 106 5 28 198 65 244 2.92E-14 74.3 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 B0V207 CHOYP_F16A2.3.3 m.62953 sp F16A2_DANRE 44.444 603 256 14 1 548 1 579 2.92E-148 474 F16A2_DANRE reviewed FTS and Hook-interacting protein homolog (FHIP) (Protein FAM160A2) fam160a2 si:ch211-39h10.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1124 early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein transport [GO:0015031] GO:0005829; GO:0007032; GO:0007040; GO:0008333; GO:0015031; GO:0045022; GO:0070695 0 0 0 PF10257; O14490 CHOYP_DLGP1.2.3 m.26037 sp DLGP1_HUMAN 44.737 114 62 1 124 237 790 902 2.92E-26 112 DLGP1_HUMAN reviewed Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) DLGAP1 DAP1 GKAP Homo sapiens (Human) 977 chemical synaptic transmission [GO:0007268] GO:0007268; GO:0014069; GO:0030054; GO:0045211 0 0 0 PF03359; O60879 CHOYP_LOC100539769.1.1 m.36990 sp DIAP2_HUMAN 48.438 192 93 2 52 239 622 811 2.92E-49 176 DIAP2_HUMAN reviewed Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) DIAPH2 DIA Homo sapiens (Human) 1101 actin filament organization [GO:0007015]; cytokinesis [GO:0000910]; female gamete generation [GO:0007292]; multicellular organism development [GO:0007275]; oogenesis [GO:0048477] GO:0000910; GO:0005102; GO:0005730; GO:0005739; GO:0005769; GO:0005794; GO:0005829; GO:0007015; GO:0007275; GO:0007292; GO:0043231; GO:0048477 0 0 0 PF06345;PF06367;PF06371;PF02181; O70277 CHOYP_BRAFLDRAFT_87279.1.10 m.3224 sp TRIM3_RAT 27.731 119 82 2 50 164 625 743 2.92E-09 58.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P04114 CHOYP_LOC100199505.1.2 m.19947 sp APOB_HUMAN 25.425 999 642 38 36 981 115 1063 2.92E-59 233 APOB_HUMAN reviewed Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)] APOB Homo sapiens (Human) 4563 artery morphogenesis [GO:0048844]; cellular protein catabolic process [GO:0044257]; cellular response to prostaglandin stimulus [GO:0071379]; cellular response to tumor necrosis factor [GO:0071356]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; leukocyte migration [GO:0050900]; lipoprotein biosynthetic process [GO:0042158]; lipoprotein catabolic process [GO:0042159]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; low-density lipoprotein particle clearance [GO:0034383]; low-density lipoprotein particle remodeling [GO:0034374]; nervous system development [GO:0007399]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; post-embryonic development [GO:0009791]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol biosynthetic process [GO:0045540]; response to carbohydrate [GO:0009743]; response to lipopolysaccharide [GO:0032496]; response to selenium ion [GO:0010269]; response to virus [GO:0009615]; retinoid metabolic process [GO:0001523]; spermatogenesis [GO:0007283]; sperm motility [GO:0030317]; triglyceride catabolic process [GO:0019433]; triglyceride mobilization [GO:0006642]; very-low-density lipoprotein particle assembly [GO:0034379] GO:0001523; GO:0001701; GO:0005543; GO:0005576; GO:0005615; GO:0005737; GO:0005769; GO:0005788; GO:0005789; GO:0005794; GO:0005829; GO:0005886; GO:0006642; GO:0006898; GO:0007283; GO:0007399; GO:0008201; GO:0008203; GO:0009566; GO:0009615; GO:0009743; GO:0009791; GO:0010008; GO:0010269; GO:0010628; GO:0010744; GO:0010884; GO:0010886; GO:0015629; GO:0017127; GO:0019433; GO:0030301; GO:0030317; GO:0030669; GO:0031904; GO:0032496; GO:0033344; GO:0034359; GO:0034360; GO:0034361; GO:0034362; GO:0034363; GO:0034374; GO:0034379; GO:0034383; GO:0035473; GO:0042157; GO:0042158; GO:0042159; GO:0042627; GO:0042632; GO:0042953; GO:0043025; GO:0043231; GO:0044257; GO:0045540; GO:0048844; GO:0050750; GO:0050900; GO:0070062; GO:0070971; GO:0071356; GO:0071379; GO:0071682 0 0 0 PF12491;PF06448;PF09172;PF01347; P04323 CHOYP_LOC754701.7.7 m.39543 sp POL3_DROME 41.553 438 241 7 783 1212 193 623 2.92E-95 332 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P05539 CHOYP_contig_018758 m.22015 sp CO2A1_RAT 46.512 215 87 4 78 265 732 945 2.92E-23 102 CO2A1_RAT reviewed Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] Col2a1 Rattus norvegicus (Rat) 1419 cartilage development [GO:0051216]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to retinoic acid [GO:0071300]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin E [GO:0071306]; chondrocyte differentiation [GO:0002062]; growth plate cartilage development [GO:0003417]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to X-ray [GO:0010165] GO:0002062; GO:0003417; GO:0005201; GO:0005585; GO:0005737; GO:0009612; GO:0010165; GO:0046872; GO:0051216; GO:0060351; GO:0071260; GO:0071300; GO:0071306; GO:0071316; GO:0071356; GO:0071374; GO:0071375; GO:0071774 0 0 0 PF01410;PF01391; P08962 CHOYP_LOC100377233.1.1 m.30409 sp CD63_HUMAN 36.019 211 131 3 2 212 3 209 2.92E-39 139 CD63_HUMAN reviewed CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) CD63 MLA1 TSPAN30 Homo sapiens (Human) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cellular protein localization [GO:0034613]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigment granule maturation [GO:0048757]; platelet degranulation [GO:0002576]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of rubidium ion transport [GO:2000680]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0002576; GO:0005615; GO:0005765; GO:0005886; GO:0005887; GO:0007160; GO:0009986; GO:0010008; GO:0010633; GO:0015031; GO:0016477; GO:0030855; GO:0031088; GO:0031226; GO:0031902; GO:0031904; GO:0032585; GO:0034613; GO:0035646; GO:0042470; GO:0043234; GO:0045785; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2000680; GO:2001046 0 0 0 PF00335; P12804 CHOYP_LOC101156984.2.2 m.22955 sp FGL2_MOUSE 40.304 263 126 8 50 282 166 427 2.92E-55 187 FGL2_MOUSE reviewed Fibroleukin (Cytotoxic T-lymphocyte-specific protein) (Fibrinogen-like protein 2) (Prothrombinase) Fgl2 Fiblp Mus musculus (Mouse) 432 cytolysis [GO:0019835] GO:0008233; GO:0019835; GO:0070062 0 0 0 PF00147; P15989 CHOYP_LOC100709262.1.2 m.17960 sp CO6A3_CHICK 24.879 824 562 22 291 1098 35 817 2.92E-62 239 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P23381 CHOYP_LCHN.1.2 m.59463 sp SYWC_HUMAN 73.684 171 45 0 21 191 81 251 2.92E-91 277 SYWC_HUMAN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS IFI53 WRS Homo sapiens (Human) 471 angiogenesis [GO:0001525]; negative regulation of cell proliferation [GO:0008285]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0001525; GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006412; GO:0006418; GO:0006436; GO:0008285; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P25067 CHOYP_COL8A1.1.1 m.66153 sp CO8A2_HUMAN 34.259 108 68 2 73 178 592 698 2.92E-12 67.4 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; P30122 CHOYP_SI_CH211-93F2.1.4.4 m.64437 sp CEL_BOVIN 31.681 464 266 18 2 441 148 584 2.92E-58 207 CEL_BOVIN reviewed Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) (Fragment) CEL Bos taurus (Bovine) 597 lipid catabolic process [GO:0016042]; modulation of synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; synapse assembly [GO:0007416] GO:0004771; GO:0004806; GO:0004872; GO:0005576; GO:0005737; GO:0005887; GO:0007158; GO:0007416; GO:0009986; GO:0016042; GO:0042043; GO:0045202; GO:0050804; GO:0052689 0 0 0 PF00135; P46530 CHOYP_LOC100634060.23.37 m.51153 sp NOTC1_DANRE 45.736 129 69 1 389 517 1098 1225 2.92E-29 126 NOTC1_DANRE reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1a notch Danio rerio (Zebrafish) (Brachydanio rerio) 2437 "angiogenesis [GO:0001525]; anterior/posterior pattern specification [GO:0009952]; cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; dorsal aorta development [GO:0035907]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; habenula development [GO:0021986]; hematopoietic progenitor cell differentiation [GO:0002244]; hypochord development [GO:0055016]; negative regulation of neurogenesis [GO:0050768]; neural plate development [GO:0001840]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; pancreas development [GO:0031016]; peripheral nervous system neuron axonogenesis [GO:0048936]; positive regulation of mesodermal cell fate specification [GO:0048337]; regulation of endodermal cell fate specification [GO:0042663]; regulation of receptor-mediated endocytosis [GO:0048259]; regulation of transcription, DNA-templated [GO:0006355]; somatic motor neuron differentiation [GO:0021523]; somitogenesis [GO:0001756]; spinal cord radial glial cell differentiation [GO:0021531]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron differentiation [GO:0021514]" GO:0001525; GO:0001756; GO:0001840; GO:0002244; GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0007219; GO:0007368; GO:0009952; GO:0016021; GO:0021514; GO:0021523; GO:0021531; GO:0021986; GO:0031016; GO:0031017; GO:0035907; GO:0042663; GO:0048259; GO:0048337; GO:0048699; GO:0048936; GO:0050768; GO:0055016; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P55214 CHOYP_CASP7.2.23 m.5415 sp CASP7_MESAU 32.418 182 95 8 5 179 61 221 2.92E-15 75.9 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 P97739 CHOYP_BRAFLDRAFT_223369.1.1 m.29420 sp ECE1_CAVPO 27.54 748 497 16 31 773 47 754 2.92E-100 329 ECE1_CAVPO reviewed Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) ECE1 Cavia porcellus (Guinea pig) 754 protein processing [GO:0016485] GO:0004222; GO:0005886; GO:0016021; GO:0016485; GO:0046872 0 0 cd08662; PF01431;PF05649; Q00194 CHOYP_BRAFLDRAFT_73083.1.1 m.36823 sp CNGA1_BOVIN 33.333 159 89 3 96 254 156 297 2.92E-19 90.1 CNGA1_BOVIN reviewed "cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)" CNGA1 CNCG CNCG1 Bos taurus (Bovine) 690 cation transport [GO:0006812]; regulation of membrane potential [GO:0042391]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0001750; GO:0005222; GO:0005223; GO:0005249; GO:0005887; GO:0006812; GO:0007601; GO:0030553; GO:0042391; GO:0042622; GO:0050896; GO:1902495 0 0 0 PF16526;PF00027;PF00520; Q02858 CHOYP_BRAFLDRAFT_85562.4.4 m.42165 sp TIE2_MOUSE 22.154 325 197 10 777 1081 673 961 2.92E-12 75.1 TIE2_MOUSE reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b) Tek Hyk Tie-2 Tie2 Mus musculus (Mouse) 1122 angiogenesis [GO:0001525]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; patterning of blood vessels [GO:0001569]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cytokine secretion involved in immune response [GO:0002741]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of endothelial cell proliferation [GO:0001936]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of NIK/NF-kappaB signaling [GO:1901222]; response to retinoic acid [GO:0032526]; single organismal cell-cell adhesion [GO:0016337]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570] GO:0001525; GO:0001569; GO:0001570; GO:0001934; GO:0001935; GO:0001936; GO:0002040; GO:0002741; GO:0004713; GO:0004714; GO:0004872; GO:0005524; GO:0005576; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007160; GO:0007169; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016021; GO:0016323; GO:0016324; GO:0016337; GO:0016525; GO:0018108; GO:0030097; GO:0030334; GO:0030949; GO:0032526; GO:0032878; GO:0033138; GO:0034446; GO:0042307; GO:0043066; GO:0043552; GO:0045121; GO:0045765; GO:0045766; GO:0045785; GO:0046777; GO:0048014; GO:0048471; GO:0050900; GO:0051259; GO:0051894; GO:0051897; GO:0060347; GO:0070374; GO:1901222; GO:1902533; GO:2000251; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q08420 CHOYP_LOC100698842.1.1 m.40947 sp SODE_RAT 29.054 148 96 7 25 171 48 187 2.92E-09 57.8 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q08DP1 CHOYP_TM10B.1.1 m.25206 sp TM10B_BOVIN 41.045 268 148 2 59 324 54 313 2.92E-63 206 TM10B_BOVIN reviewed tRNA methyltransferase 10 homolog B (EC 2.1.1.-) (RNA (guanine-9-)-methyltransferase domain-containing protein 3) TRMT10B RG9MTD3 Bos taurus (Bovine) 316 0 GO:0008168 0 0 0 PF01746; Q1HG43 CHOYP_LOC100367809.1.2 m.38594 sp DOXA1_HUMAN 33.724 341 202 8 18 348 10 336 2.92E-49 173 DOXA1_HUMAN reviewed Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) 343 hydrogen peroxide metabolic process [GO:0042743]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609] GO:0005789; GO:0005886; GO:0015031; GO:0016020; GO:0016021; GO:0042743; GO:0045666; GO:0050727; GO:2000379; GO:2000609 0 0 0 PF10204; Q28EW0 CHOYP_LOC100706133.1.1 m.56708 sp TM87A_XENTR 44.894 568 254 14 10 568 24 541 2.92E-156 461 TM87A_XENTR reviewed Transmembrane protein 87A tmem87a TGas047b06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 541 0 GO:0016021 0 0 0 PF06814; Q460N5 CHOYP_PARP14.22.22 m.65230 sp PAR14_HUMAN 27.017 533 348 16 1 515 862 1371 2.92E-46 179 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5BIM1 CHOYP_LOC100632153.3.6 m.34201 sp TRI45_BOVIN 24.671 304 180 12 18 289 29 315 2.92E-12 73.2 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6DIB5 CHOYP_MEG11.17.25 m.51078 sp MEG10_MOUSE 38.835 103 55 4 4 106 568 662 2.92E-11 63.5 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6XIM8 CHOYP_RS15A.10.11 m.38088 sp RS15A_DROYA 76.404 89 21 0 4 92 31 119 2.92E-48 152 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q8C525 CHOYP_NEMVEDRAFT_V1G196611.5.13 m.24267 sp M21D2_MOUSE 25.143 175 119 5 59 232 159 322 2.92E-07 56.6 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8MPM1 CHOYP_LOC100642024.2.2 m.49267 sp GELS2_LUMTE 57.568 370 150 4 1 367 1 366 2.92E-150 431 GELS2_LUMTE reviewed Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) 366 actin filament capping [GO:0051693] GO:0005737; GO:0005856; GO:0051693 0 0 0 PF00626; Q8ND56 CHOYP_LS14A.2.3 m.10984 sp LS14A_HUMAN 41.667 480 211 12 1 450 1 441 2.92E-71 240 LS14A_HUMAN reviewed Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) LSM14A C19orf13 FAM61A RAP55 RAP55A Homo sapiens (Human) 463 cytoplasmic mRNA processing body assembly [GO:0033962]; multicellular organism development [GO:0007275]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of translation [GO:0006417]; RIG-I signaling pathway [GO:0039529] GO:0000932; GO:0003690; GO:0003725; GO:0003727; GO:0005737; GO:0006417; GO:0007275; GO:0010494; GO:0033962; GO:0039529; GO:0043231; GO:0044822; GO:0060340 0 0 0 PF09532;PF12701; Q98ST7 CHOYP_ACDOPBH.9.9 m.63296 sp MOXD1_CHICK 30.11 362 229 13 175 517 189 545 2.92E-37 149 MOXD1_CHICK reviewed DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X) MOXD1 DBHR MOX Gallus gallus (Chicken) 614 0 GO:0005507; GO:0005789; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q9TU19 CHOYP_LOC100375699.1.2 m.19738 sp NPHP1_CANLF 38.739 555 318 5 237 791 26 558 2.92E-129 400 NPHP1_CANLF reviewed Nephrocystin-1 (Fragment) NPHP1 NPH1 Canis lupus familiaris (Dog) (Canis familiaris) 565 cell differentiation [GO:0030154]; cell projection organization [GO:0030030]; spermatogenesis [GO:0007283] GO:0005737; GO:0005856; GO:0005911; GO:0005912; GO:0005923; GO:0005929; GO:0007283; GO:0030030; GO:0030154 0 0 0 PF00018; Q9U489 CHOYP_BRAFLDRAFT_241726.18.22 m.46272 sp LIN41_CAEEL 27.059 170 103 7 41 204 812 966 2.92E-06 51.2 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9UDX3 CHOYP_S14L2.1.1 m.8313 sp S14L4_HUMAN 61.905 105 39 1 13 116 283 387 2.92E-39 139 S14L4_HUMAN reviewed SEC14-like protein 4 (Tocopherol-associated protein 3) SEC14L4 TAP3 Homo sapiens (Human) 406 0 GO:0005215; GO:0005622; GO:0008289; GO:0016021 0 0 0 PF00650; Q9VSL3 CHOYP_GSTO1.2.2 m.26202 sp SEPIA_DROME 34.653 101 64 2 14 112 138 238 2.92E-13 66.6 SEPIA_DROME reviewed Pyrimidodiazepine synthase (EC 1.5.4.1) (Protein sepia) se CG6781 Drosophila melanogaster (Fruit fly) 243 eye pigment biosynthetic process [GO:0006726]; glutathione metabolic process [GO:0006749]; pteridine biosynthetic process [GO:0006728] GO:0004364; GO:0004734; GO:0005737; GO:0006726; GO:0006728; GO:0006749; GO:0016782; GO:0042803; GO:0045174 0 0 0 PF13417; A4IF63 CHOYP_LOC100373444.72.79 m.60850 sp TRIM2_BOVIN 23.297 279 194 10 307 573 472 742 2.93E-13 76.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7RR34 CHOYP_LOC100185443.1.1 m.60976 sp FLTOP_NEMVE 55.435 92 41 0 1 92 1 92 2.93E-32 119 FLTOP_NEMVE reviewed Protein Flattop homolog (Cilia- and flagella-associated protein 126) v1g200856 Nematostella vectensis (Starlet sea anemone) 169 cilium organization [GO:0044782] GO:0005737; GO:0016324; GO:0036064; GO:0044782; GO:0072372 0 0 0 0 B2RX88 CHOYP_CSPP1.13.14 m.63987 sp CSPP1_MOUSE 32.759 754 368 26 140 836 498 1169 2.93E-52 201 CSPP1_MOUSE reviewed Centrosome and spindle pole associated protein 1 Cspp1 Cspp Mus musculus (Mouse) 1205 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 D3YXG0 CHOYP_AAEL_AAEL003853.2.2 m.61199 sp HMCN1_MOUSE 25.355 493 320 23 127 597 3793 4259 2.93E-17 91.3 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; F1LZF0 CHOYP_KLHL3.1.1 m.45406 sp KLHL2_RAT 25.726 241 163 7 139 375 22 250 2.93E-21 99 KLHL2_RAT reviewed Kelch-like protein 2 (Mayven) Klhl2 Rattus norvegicus (Rat) 593 protein ubiquitination [GO:0016567] GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0031463 0 0 0 PF07707;PF00651;PF01344; G5E8F4 CHOYP_FPGT.1.1 m.57120 sp FPGT_MOUSE 40.468 598 313 11 24 612 15 578 2.93E-138 418 FPGT_MOUSE reviewed Fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) (GDP-L-fucose diphosphorylase) (GDP-L-fucose pyrophosphorylase) Fpgt Mus musculus (Mouse) 590 0 GO:0005525; GO:0005737; GO:0047341 0 0 0 PF07959; O15084 CHOYP_ANR28.2.3 m.26222 sp ANR28_HUMAN 55.172 116 51 1 2 116 849 964 2.93E-32 123 ANR28_HUMAN reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) ANKRD28 KIAA0379 Homo sapiens (Human) 1053 COPII vesicle coating [GO:0048208] GO:0000139; GO:0005654; GO:0005829; GO:0048208 0 0 0 PF00023;PF12796; O70277 CHOYP_BRAFLDRAFT_87272.3.6 m.42010 sp TRIM3_RAT 28.571 119 81 3 63 178 625 742 2.93E-07 53.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_LOC100374741.52.83 m.47075 sp TRIM3_HUMAN 21.387 519 327 16 82 561 115 591 2.93E-13 76.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P11118 CHOYP_CALM.3.50 m.2874 sp CALM_EUGGR 46.218 119 61 1 103 221 31 146 2.93E-27 105 CALM_EUGGR reviewed Calmodulin (CaM) 0 Euglena gracilis 149 0 GO:0005509 0 0 0 PF13499; P18445 CHOYP_LOC100533291.7.7 m.42454 sp RL27A_RAT 75.676 148 35 1 30 176 1 148 2.93E-78 232 RL27A_RAT reviewed 60S ribosomal protein L27a Rpl27a Rattus norvegicus (Rat) 148 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00828; P24367 CHOYP_PPIB.4.4 m.63702 sp PPIB_CHICK 66.854 178 59 0 37 214 25 202 2.93E-84 251 PPIB_CHICK reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207 chaperone-mediated protein folding [GO:0061077]; protein peptidyl-prolyl isomerization [GO:0000413] GO:0000413; GO:0003755; GO:0005788; GO:0032403; GO:0032991; GO:0042277; GO:0042470; GO:0061077 0 0 0 PF00160; P42573 CHOYP_CED3.1.1 m.44803 sp CED3_CAEEL 28.411 535 282 17 1 474 2 496 2.93E-37 146 CED3_CAEEL reviewed Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 C48D1.2 Caenorhabditis elegans 503 apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; embryo development ending in birth or egg hatching [GO:0009792]; execution phase of apoptosis [GO:0097194]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; regulation of apoptotic process [GO:0042981]; regulation of cell adhesion [GO:0030155] GO:0004175; GO:0004197; GO:0005737; GO:0006915; GO:0009792; GO:0012501; GO:0016020; GO:0016540; GO:0030155; GO:0030163; GO:0042802; GO:0042981; GO:0048471; GO:0097194; GO:0097200; GO:1902742 0 0 0 PF00619; P57788 CHOYP_LOC561627.1.1 m.25119 sp MOT4_CHICK 26.797 459 317 9 3 452 20 468 2.93E-46 171 MOT4_CHICK reviewed Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3) SLC16A3 MCT4 Gallus gallus (Chicken) 473 0 GO:0005887; GO:0008028; GO:0015129; GO:0015293; GO:0015629; GO:0031965; GO:0044822 0 0 cd06174; PF07690; P70684 CHOYP_HPGD.3.3 m.60098 sp PGDH_CAVPO 33.333 99 62 1 1 95 156 254 2.93E-13 66.6 PGDH_CAVPO reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) 265 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; P79102 CHOYP_NEMVEDRAFT_V1G190607.1.1 m.56172 sp CP3AS_BOVIN 29.175 497 337 9 19 513 13 496 2.93E-65 223 CP3AS_BOVIN reviewed Cytochrome P450 3A28 (EC 1.14.14.1) (CYPIIIA28) CYP3A28 Bos taurus (Bovine) 507 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q09654 CHOYP_LOC100374741.13.83 m.17527 sp TRI23_CAEEL 26.291 213 123 7 20 211 115 314 2.93E-07 55.8 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q3L254 CHOYP_WNT7B.2.2 m.54851 sp WNT7B_CHICK 64.264 333 115 3 45 375 19 349 2.93E-160 456 WNT7B_CHICK reviewed Protein Wnt-7b WNT7B Gallus gallus (Chicken) 349 cell fate commitment [GO:0045165]; lens fiber cell development [GO:0070307]; neuron differentiation [GO:0030182]; Wnt signaling pathway [GO:0016055] GO:0005109; GO:0005578; GO:0005615; GO:0016055; GO:0030182; GO:0045165; GO:0070307 0 0 0 PF00110; Q5BJI9 CHOYP_LOC101063838.1.1 m.50540 sp SPCS2_DANRE 60.963 187 73 0 29 215 13 199 2.93E-82 246 SPCS2_DANRE reviewed Probable signal peptidase complex subunit 2 (EC 3.4.-.-) (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) spcs2 zgc:110364 Danio rerio (Zebrafish) (Brachydanio rerio) 201 protein targeting to ER [GO:0045047]; signal peptide processing [GO:0006465] GO:0005787; GO:0006465; GO:0008233; GO:0016021; GO:0031090; GO:0045047 0 0 0 PF06703; Q5SZD4 CHOYP_LOC566887.1.1 m.45765 sp GLYL3_HUMAN 24.803 254 147 9 43 274 41 272 2.93E-09 60.1 GLYL3_HUMAN reviewed Glycine N-acyltransferase-like protein 3 (EC 2.3.1.-) GLYATL3 C6orf140 Homo sapiens (Human) 288 0 GO:0005739; GO:0047961 0 0 0 PF08444;PF06021; Q5ZIF1 CHOYP_APMAP.1.1 m.51836 sp APMAP_CHICK 45.542 415 219 5 1 410 1 413 2.93E-123 366 APMAP_CHICK reviewed Adipocyte plasma membrane-associated protein APMAP RCJMB04_27f14 Gallus gallus (Chicken) 415 biosynthetic process [GO:0009058] GO:0004064; GO:0005783; GO:0009058; GO:0009986; GO:0016020; GO:0016021; GO:0016788; GO:0016844; GO:0070062 0 0 0 PF03088; Q6INU7 CHOYP_AAEL_AAEL006322.1.3 m.6165 sp FRRS1_XENLA 29.595 642 370 21 7 626 8 589 2.93E-90 294 FRRS1_XENLA reviewed Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) 590 0 GO:0016021; GO:0016491 0 0 cd08544; PF03188;PF03351;PF02014; Q7L0X2 CHOYP_BRAFLDRAFT_117750.1.1 m.12162 sp ERIP6_HUMAN 32.941 425 239 12 216 628 238 628 2.93E-53 197 ERIP6_HUMAN reviewed Glutamate-rich protein 6 (Protein FAM194A) ERICH6 C3orf44 FAM194A Homo sapiens (Human) 663 0 0 0 0 0 PF14977; Q8QGW7 CHOYP_NEMVEDRAFT_V1G129909.2.9 m.5371 sp LITAF_CHICK 49.02 102 46 2 32 131 51 148 2.93E-24 94 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q90YI5 CHOYP_TIM8A.1.1 m.4787 sp TIM8A_TAKRU 54.054 74 34 0 28 101 7 80 2.93E-22 86.3 TIM8A_TAKRU reviewed Mitochondrial import inner membrane translocase subunit Tim8 A timm8a ddp tim8a Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 90 protein transport [GO:0015031] GO:0005743; GO:0015031; GO:0046872 0 0 0 PF02953; Q91240 CHOYP_LOC373275.2.7 m.14501 sp TBB_PSEAM 98.462 65 1 0 1 65 202 266 2.93E-41 144 TBB_PSEAM reviewed Tubulin beta chain (Beta-tubulin) 0 Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q91754 CHOYP_GCKR.1.1 m.51743 sp GCKR_XENLA 40.339 590 321 10 2 571 27 605 2.93E-154 459 GCKR_XENLA reviewed Glucokinase regulatory protein (Glucokinase regulator) gckr Xenopus laevis (African clawed frog) 619 carbohydrate metabolic process [GO:0005975]; negative regulation of glucokinase activity [GO:0033132] GO:0005654; GO:0005737; GO:0005975; GO:0030246; GO:0033132; GO:0070095 0 0 0 0 Q9D9R9 CHOYP_NEMVEDRAFT_V1G214844.22.34 m.54623 sp F186A_MOUSE 39.806 412 164 23 1242 1602 588 966 2.93E-25 119 F186A_MOUSE reviewed Protein FAM186A FAM186A Gm920 Mus musculus (Mouse) 1790 0 0 0 0 0 0 Q9DBU3 CHOYP_RIOK3.1.1 m.54195 sp RIOK3_MOUSE 54.357 482 195 8 44 514 23 490 2.93E-177 515 RIOK3_MOUSE reviewed Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) Riok3 Mus musculus (Mouse) 519 0 GO:0004674; GO:0005524; GO:0046872 0 0 0 0 Q9H0E2 CHOYP_TOLIP.1.1 m.57590 sp TOLIP_HUMAN 53.659 287 106 7 49 325 4 273 2.93E-93 281 TOLIP_HUMAN reviewed Toll-interacting protein TOLLIP Homo sapiens (Human) 274 autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; epithelial cell differentiation [GO:0030855]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; leukocyte activation [GO:0045321]; phosphorylation [GO:0016310]; positive regulation of protein sumoylation [GO:0033235]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165] GO:0004871; GO:0005737; GO:0005829; GO:0006914; GO:0006954; GO:0007165; GO:0007267; GO:0016310; GO:0016604; GO:0019900; GO:0030855; GO:0033235; GO:0035325; GO:0035556; GO:0036010; GO:0045087; GO:0045092; GO:0045321; GO:0045323; GO:0048471; GO:0070062 0 0 0 PF00168;PF02845; Q9H8W5 CHOYP_TRI45.8.23 m.32423 sp TRI45_HUMAN 23.81 273 184 10 5 260 128 393 2.93E-11 68.9 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9NBX4 CHOYP_MYO3AL.1.1 m.8125 sp RTXE_DROME 36.885 122 76 1 28 148 440 561 2.93E-15 75.1 RTXE_DROME reviewed Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) 908 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; A0JM12 CHOYP_LOC763793.2.7 m.24286 sp MEG10_XENTR 36.819 679 369 32 3 662 122 759 2.94E-88 301 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; O00370 CHOYP_LOC580961.2.2 m.35210 sp LORF2_HUMAN 22.74 365 265 9 3 358 492 848 2.94E-14 80.9 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O35115 CHOYP_SMP_048560.1.2 m.58825 sp FHL2_RAT 50.424 236 109 1 45 280 3 230 2.94E-86 262 FHL2_RAT reviewed Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) Fhl2 Dral Slim3 Rattus norvegicus (Rat) 279 "atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; transcription, DNA-templated [GO:0006351]; ventricular cardiac muscle cell development [GO:0055015]" GO:0000122; GO:0001649; GO:0005634; GO:0005925; GO:0006351; GO:0008134; GO:0008270; GO:0009725; GO:0015629; GO:0030018; GO:0031430; GO:0043066; GO:0055014; GO:0055015; GO:0060347 0 0 0 PF00412; O75382 CHOYP_BRAFLDRAFT_87295.3.9 m.32819 sp TRIM3_HUMAN 22.963 135 89 3 113 245 622 743 2.94E-06 52 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P16444 CHOYP_LOC100876551.1.1 m.4580 sp DPEP1_HUMAN 49.459 370 173 5 126 494 23 379 2.94E-126 377 DPEP1_HUMAN reviewed Dipeptidase 1 (EC 3.4.13.19) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP) DPEP1 MDP RDP Homo sapiens (Human) 411 antibiotic metabolic process [GO:0016999]; cellular lactam catabolic process [GO:0072340]; cellular response to calcium ion [GO:0071277]; cellular response to drug [GO:0035690]; cellular response to nitric oxide [GO:0071732]; glutathione metabolic process [GO:0006749]; homocysteine metabolic process [GO:0050667]; leukotriene metabolic process [GO:0006691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; xenobiotic metabolic process [GO:0006805] GO:0005615; GO:0005886; GO:0006691; GO:0006749; GO:0006805; GO:0008235; GO:0008239; GO:0008270; GO:0016324; GO:0016805; GO:0016999; GO:0030336; GO:0031225; GO:0031528; GO:0034235; GO:0035690; GO:0043027; GO:0043066; GO:0043154; GO:0045177; GO:0050667; GO:0070062; GO:0070573; GO:0071277; GO:0071732; GO:0072340; GO:0072341 0 0 0 PF01244; P16924 CHOYP_P4HA1.1.5 m.11629 sp P4HA1_CHICK 30.586 546 297 14 23 524 3 510 2.94E-60 210 P4HA1_CHICK reviewed "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1)" P4HA1 P4HA Gallus gallus (Chicken) 516 0 GO:0004656; GO:0005506; GO:0005788; GO:0016702; GO:0031418 0 0 0 PF13640;PF08336; P36241 CHOYP_contig_039811 m.44996 sp RL19_DROME 79.429 175 36 0 1 175 11 185 2.94E-88 263 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P41824 CHOYP_YBOX1.1.1 m.20797 sp YBOXH_APLCA 78.571 98 21 0 30 127 27 124 2.94E-47 162 YBOXH_APLCA reviewed Y-box factor homolog (APY1) 0 Aplysia californica (California sea hare) 253 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355 0 0 cd04458; PF00313; P48166 CHOYP_LOC100180220.1.3 m.34672 sp RL36A_CAEEL 77.885 104 22 1 15 118 3 105 2.94E-52 162 RL36A_CAEEL reviewed Ribosomal protein L36.A (60S ribosomal protein L44) (L41) rpl-36.A rpl-41 C09H10.2 Caenorhabditis elegans 105 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00935; P51612 CHOYP_XPC.1.1 m.17473 sp XPC_MOUSE 39.974 773 402 17 393 1115 138 898 2.94E-168 523 XPC_MOUSE reviewed DNA repair protein complementing XP-C cells homolog (Xeroderma pigmentosum group C-complementing protein homolog) (p125) Xpc Mus musculus (Mouse) 930 "cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; intra-S DNA damage checkpoint [GO:0031573]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to auditory stimulus [GO:0010996]; response to drug [GO:0042493]; response to UV-B [GO:0010224]; UV-damage excision repair [GO:0070914]" GO:0000111; GO:0000715; GO:0003684; GO:0003697; GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006281; GO:0006289; GO:0006298; GO:0006974; GO:0010224; GO:0010996; GO:0031573; GO:0042493; GO:0070062; GO:0070914; GO:0071942; GO:1901990 0 0 0 PF10403;PF10404;PF10405;PF03835; P53486 CHOYP_LOC100890099.1.1 m.11505 sp ACTB3_TAKRU 82.857 280 10 1 1 280 119 360 2.94E-166 468 ACTB3_TAKRU reviewed "Actin, cytoplasmic 3 (Beta-actin C) [Cleaved into: Actin, cytoplasmic 3, N-terminally processed]" actbc Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P91931 CHOYP_LOC100898038.2.2 m.65973 sp DCAM_DROME 52.239 134 62 2 8 140 8 140 2.94E-40 141 DCAM_DROME reviewed S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] SamDC CG5029 Drosophila melanogaster (Fruit fly) 347 defense response to Gram-negative bacterium [GO:0050829]; S-adenosylmethioninamine biosynthetic process [GO:0006557]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597] GO:0004014; GO:0005829; GO:0006557; GO:0006597; GO:0008295; GO:0050829 PATHWAY: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. 0 0 PF01536; Q13310 CHOYP_PABP4.1.6 m.6069 sp PABP4_HUMAN 41.688 391 184 7 11 399 58 406 2.94E-83 270 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q54KA7 CHOYP_AFUA_1G01020.13.50 m.23829 sp SECG_DICDI 36.901 355 223 1 1 354 173 527 2.94E-60 212 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q571G4 CHOYP_LOC100377596.1.1 m.7350 sp LIN54_MOUSE 50.734 477 151 10 319 778 334 743 2.94E-132 413 LIN54_MOUSE reviewed Protein lin-54 homolog Lin54 Kiaa2037 Mus musculus (Mouse) 749 "cell cycle [GO:0007049]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007049 0 0 0 PF03638; Q5DW34 CHOYP_LOC100871691.1.1 m.55692 sp EHMT1_MOUSE 25.763 295 187 13 152 439 705 974 2.94E-09 63.5 EHMT1_MOUSE reviewed Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) 1296 "chromatin modification [GO:0016568]; DNA methylation [GO:0006306]; embryo development [GO:0009790]; histone methylation [GO:0016571]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; response to fungicide [GO:0060992]" GO:0000122; GO:0002039; GO:0005634; GO:0005654; GO:0005694; GO:0006306; GO:0008168; GO:0008270; GO:0009790; GO:0016279; GO:0016568; GO:0016571; GO:0018024; GO:0018026; GO:0018027; GO:0045892; GO:0046974; GO:0046976; GO:0060992; GO:0070742 0 0 0 PF12796;PF05033;PF00856; Q5R9W6 CHOYP_TAF13.3.3 m.63480 sp TAF13_PONAB 73.469 98 26 0 22 119 27 124 2.94E-51 160 TAF13_PONAB reviewed Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18) TAF13 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 124 "regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0005634; GO:0006355; GO:0006366 0 0 cd07978; PF02269; Q5XKE0 CHOYP_LOAG_01021.3.4 m.54619 sp MYPC2_MOUSE 23.315 356 229 12 60 404 308 630 2.94E-07 58.2 MYPC2_MOUSE reviewed "Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)" Mybpc2 Mus musculus (Mouse) 1136 cell adhesion [GO:0007155]; muscle contraction [GO:0006936] GO:0005200; GO:0005856; GO:0006936; GO:0007155; GO:0032982 0 0 0 PF00041;PF07679; Q5ZIT5 CHOYP_BRAFLDRAFT_131227.1.1 m.24973 sp RAB10_CHICK 79 200 41 1 1 199 1 200 2.94E-113 324 RAB10_CHICK reviewed Ras-related protein Rab-10 RAB10 RCJMB04_23k10 Gallus gallus (Chicken) 200 axonogenesis [GO:0007409]; basolateral protein localization [GO:0061467]; cellular response to insulin stimulus [GO:0032869]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; polarized epithelial cell differentiation [GO:0030859]; protein localization to plasma membrane [GO:0072659]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005768; GO:0005789; GO:0005794; GO:0005802; GO:0006893; GO:0007264; GO:0007409; GO:0016192; GO:0016197; GO:0019003; GO:0030670; GO:0030859; GO:0032593; GO:0032869; GO:0043001; GO:0045200; GO:0055037; GO:0055038; GO:0061467; GO:0071782; GO:0071786; GO:0072372; GO:0072659; GO:0097051 0 0 0 PF00071; Q6DIR5 CHOYP_TES.1.1 m.1577 sp TES_XENTR 35.904 415 212 6 65 442 22 419 2.94E-88 278 TES_XENTR reviewed Testin tes TNeu019j18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 422 neural crest cell migration [GO:0001755]; regulation of cell proliferation [GO:0042127] GO:0001755; GO:0005737; GO:0005925; GO:0005938; GO:0008270; GO:0042127 0 0 cd09829; PF00412;PF06297; Q6NZG4 CHOYP_RGD1559690.1.1 m.6208 sp DDIAS_MOUSE 32.8 125 78 2 7 126 7 130 2.94E-16 85.9 DDIAS_MOUSE reviewed DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein) Ddias Noxin Mus musculus (Mouse) 898 apoptotic process [GO:0006915]; cellular response to cytokine stimulus [GO:0071345]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to hydroperoxide [GO:0071447]; cellular response to UV [GO:0034644]; hemopoiesis [GO:0030097]; mitotic cell cycle arrest [GO:0071850]; negative regulation of fibroblast apoptotic process [GO:2000270]; spermatid development [GO:0007286] GO:0005634; GO:0005737; GO:0006915; GO:0006974; GO:0007286; GO:0030097; GO:0034644; GO:0071345; GO:0071447; GO:0071480; GO:0071850; GO:2000270 0 0 0 PF08646; Q8K0U4 CHOYP_BRAFLDRAFT_208436.27.32 m.61231 sp HS12A_MOUSE 31.769 554 306 14 37 531 29 569 2.94E-83 275 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N6D5 CHOYP_LOC100369901.1.2 m.9586 sp ANR29_HUMAN 50.177 283 141 0 33 315 3 285 2.94E-89 272 ANR29_HUMAN reviewed Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) 301 0 0 0 0 0 PF00023;PF12796; Q96LY2 CHOYP_LOC100377585.1.3 m.10554 sp CC74B_HUMAN 53.448 58 27 0 69 126 41 98 2.94E-10 64.7 CC74B_HUMAN reviewed Coiled-coil domain-containing protein 74B CCDC74B Homo sapiens (Human) 380 0 0 0 0 0 PF14917; Q96MM6 CHOYP_ISCW_ISCW012626.2.4 m.37021 sp HS12B_HUMAN 31.719 640 355 14 9 579 60 686 2.94E-102 327 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9MZD1 CHOYP_LOC574944.1.1 m.42985 sp S17A5_SHEEP 48.276 174 82 4 8 173 2 175 2.94E-42 150 S17A5_SHEEP reviewed Sialin (Membrane glycoprotein SP55) (Sodium/sialic acid cotransporter) (Solute carrier family 17 member 5) SLC17A5 Ovis aries (Sheep) 495 0 GO:0005765; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q9W770 CHOYP_LOC100313594.1.1 m.11218 sp SPON1_CHICK 31.561 602 331 19 56 637 65 605 2.94E-82 279 SPON1_CHICK reviewed Spondin-1 (F-spondin) SPON1 Gallus gallus (Chicken) 802 cell adhesion [GO:0007155] GO:0005578; GO:0007155; GO:0046872 0 0 cd08544; PF02014;PF06468;PF00090; B4GAN3 CHOYP_LOC100871317.1.1 m.54165 sp QVR_DROPE 33.846 130 79 4 3 128 7 133 2.95E-13 66.2 QVR_DROPE reviewed Protein quiver (Protein sleepless) qvr sss GL11411 Drosophila persimilis (Fruit fly) 160 "positive regulation of voltage-gated potassium channel activity [GO:1903818]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of synaptic transmission, cholinergic [GO:0032222]; rhythmic process [GO:0048511]; sleep [GO:0030431]" GO:0005886; GO:0030431; GO:0031225; GO:0032222; GO:0034235; GO:0045187; GO:0048511; GO:1903818 0 0 0 PF17064; D2GXS7 CHOYP_BRAFLDRAFT_92727.4.17 m.27365 sp TRIM2_AILME 24.476 143 105 2 12 152 602 743 2.95E-08 56.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E9Q557 CHOYP_TVAG_012450.7.8 m.63509 sp DESP_MOUSE 24.468 470 282 15 361 807 1391 1810 2.95E-07 58.9 DESP_MOUSE reviewed Desmoplakin (DP) Dsp Mus musculus (Mouse) 2883 adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; desmosome organization [GO:0002934]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein localization to adherens junction [GO:0071896]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; single organismal cell-cell adhesion [GO:0016337]; skin development [GO:0043588]; ventricular compact myocardium morphogenesis [GO:0003223]; wound healing [GO:0042060] GO:0001533; GO:0002934; GO:0003223; GO:0005080; GO:0005198; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0005916; GO:0014704; GO:0016020; GO:0016323; GO:0016337; GO:0018149; GO:0030057; GO:0030216; GO:0030674; GO:0034332; GO:0042060; GO:0043588; GO:0044822; GO:0045104; GO:0045109; GO:0070062; GO:0071896; GO:0086073; GO:0086091; GO:0097110; GO:0098911 0 0 0 PF00681; H2A0K6 CHOYP_VRP.2.4 m.18914 sp VRP_PINMG 44.167 240 119 5 1 236 1 229 2.95E-35 135 VRP_PINMG reviewed Valine-rich protein (Alveoline-like protein) 0 Pinctada margaritifera (Black-lipped pearl oyster) 238 0 GO:0005576 0 0 0 0 O95045 CHOYP_LOC100646810.1.1 m.25033 sp UPP2_HUMAN 54.422 294 130 3 20 312 27 317 2.95E-110 325 UPP2_HUMAN reviewed Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3) UPP2 Homo sapiens (Human) 317 nucleoside metabolic process [GO:0009116]; nucleotide catabolic process [GO:0009166]; pyrimidine nucleoside catabolic process [GO:0046135]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]; uridine metabolic process [GO:0046108] GO:0004850; GO:0005829; GO:0009116; GO:0009166; GO:0043097; GO:0044206; GO:0045098; GO:0046108; GO:0046135 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. 0 0 PF01048; P22105 CHOYP_MEGF6.23.59 m.34454 sp TENX_HUMAN 33.333 117 72 6 179 291 235 349 2.95E-10 64.7 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P23511 CHOYP_LOC100906398.1.1 m.62434 sp NFYA_HUMAN 69.663 89 25 1 297 383 237 325 2.95E-33 130 NFYA_HUMAN reviewed Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) NFYA Homo sapiens (Human) 347 "positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; rhythmic process [GO:0048511]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0001046; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0006366; GO:0016602; GO:0032993; GO:0045893; GO:0048511 0 0 0 PF02045; P27609 CHOYP_LOC101072697.1.1 m.41896 sp HMEN_BOMMO 65.753 146 41 1 81 226 229 365 2.95E-58 191 HMEN_BOMMO reviewed Segmentation polarity homeobox protein engrailed en Bombyx mori (Silk moth) 372 "regulation of transcription, DNA-templated [GO:0006355]; segment polarity determination [GO:0007367]" GO:0005634; GO:0006355; GO:0007367; GO:0043565 0 0 0 PF10525;PF00046; P27701 CHOYP_LOC100374248.3.5 m.25423 sp CD82_HUMAN 26.616 263 168 6 113 374 24 262 2.95E-21 95.5 CD82_HUMAN reviewed CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) CD82 KAI1 SAR2 ST6 TSPAN27 Homo sapiens (Human) 267 cell surface receptor signaling pathway [GO:0007166] GO:0005886; GO:0005887; GO:0007166; GO:0070062 0 0 0 PF00335; P53563 CHOYP_contig_055376 m.66049 sp B2CL1_RAT 33.019 106 60 4 620 716 90 193 2.95E-06 52.8 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; P74148 CHOYP_LOC100177679.1.1 m.54177 sp Y1388_SYNY3 28.824 170 104 6 11 180 2 154 2.95E-13 67.4 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P86986 CHOYP_IMSP5.2.2 m.17779 sp IMSP5_RUDPH 28.682 129 89 1 1 129 1 126 2.95E-09 54.7 IMSP5_RUDPH reviewed Insoluble matrix shell protein 5 (IMSP5) 0 Ruditapes philippinarum (Japanese littleneck clam) (Venerupis philippinarum) 135 0 GO:0005509; GO:0005576 0 0 0 PF13202; Q02645 CHOYP_ADD.2.5 m.15081 sp HTS_DROME 46.037 593 276 10 33 597 26 602 2.95E-177 542 HTS_DROME reviewed Protein hu-li tai shao (Adducin-like protein) hts CG9325 Drosophila melanogaster (Fruit fly) 1156 "actin filament bundle organization [GO:0061572]; adult somatic muscle development [GO:0007527]; axon guidance [GO:0007411]; centrosome organization [GO:0051297]; cystoblast division [GO:0007282]; female germ-line cyst formation [GO:0048135]; female germline ring canal formation, actin assembly [GO:0008302]; fusome organization [GO:0045478]; germarium-derived oocyte fate determination [GO:0007294]; germ-line cyst formation [GO:0048134]; locomotion involved in locomotory behavior [GO:0031987]; meiotic spindle organization [GO:0000212]; neuron cellular homeostasis [GO:0070050]; oogenesis [GO:0048477]; ovarian fusome organization [GO:0030723]; photoreceptor cell axon guidance [GO:0072499]; sarcomere organization [GO:0045214]; spectrosome organization [GO:0030721]; testicular fusome organization [GO:0030724]" GO:0000212; GO:0005737; GO:0005811; GO:0005856; GO:0005886; GO:0007282; GO:0007294; GO:0007411; GO:0007527; GO:0008302; GO:0016328; GO:0030721; GO:0030723; GO:0030724; GO:0031987; GO:0035183; GO:0045169; GO:0045170; GO:0045172; GO:0045214; GO:0045478; GO:0048134; GO:0048135; GO:0048477; GO:0051297; GO:0061572; GO:0070050; GO:0072499 0 0 0 PF00596; Q13637 CHOYP_LOC100370154.1.2 m.27385 sp RAB32_HUMAN 70.476 210 58 2 29 238 20 225 2.95E-106 308 RAB32_HUMAN reviewed Ras-related protein Rab-32 RAB32 Homo sapiens (Human) 225 antigen processing and presentation [GO:0019882]; endosome to melanosome transport [GO:0035646]; melanosome assembly [GO:1903232]; phagosome maturation [GO:0090382]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005769; GO:0005783; GO:0005802; GO:0007264; GO:0016020; GO:0019882; GO:0030670; GO:0030742; GO:0035646; GO:0035650; GO:0035651; GO:0036461; GO:0042470; GO:0044233; GO:0045335; GO:0090382; GO:1903232 0 0 0 PF00071; Q16G71 CHOYP_LOC100647975.2.2 m.46556 sp MED10_AEDAE 69.231 130 39 1 5 134 2 130 2.95E-62 189 MED10_AEDAE reviewed Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) MED10 AAEL014501 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 130 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592 0 0 0 PF09748; Q566M8 CHOYP_RN150.1.1 m.52884 sp RN150_DANRE 37.561 410 219 8 34 432 14 397 2.95E-78 253 RN150_DANRE reviewed RING finger protein 150 rnf150 zgc:92168 Danio rerio (Zebrafish) (Brachydanio rerio) 419 0 GO:0008270; GO:0016021 0 0 0 PF13639; Q566S6 CHOYP_LOC100114305.1.1 m.43102 sp DRS7B_DANRE 51.648 273 130 1 15 285 18 290 2.95E-90 273 DRS7B_DANRE reviewed Dehydrogenase/reductase SDR family member 7B (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 32C member 1) dhrs7b sdr32c1 zgc:112518 Danio rerio (Zebrafish) (Brachydanio rerio) 309 0 GO:0005789; GO:0016021; GO:0016491 0 0 0 PF00106; Q58728 CHOYP_SDK2.1.1 m.7298 sp Y1332_METJA 59.184 49 19 1 121 169 3 50 2.95E-10 60.8 Y1332_METJA reviewed Uncharacterized GTP-binding protein MJ1332 MJ1332 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 393 0 GO:0005525 0 0 0 PF01926;PF08438;PF02824; Q58DU5 CHOYP_BRAFLDRAFT_264234.1.2 m.5174 sp PSA3_BOVIN 74.118 255 66 0 75 329 1 255 2.95E-142 405 PSA3_BOVIN reviewed Proteasome subunit alpha type-3 (EC 3.4.25.1) PSMA3 Bos taurus (Bovine) 255 ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0006511; GO:0019773; GO:0070062 0 0 0 PF00227;PF10584; Q5R4N7 CHOYP_REV1.1.1 m.20234 sp REV1_PONAB 44.783 230 95 9 12 233 7 212 2.95E-45 169 REV1_PONAB reviewed DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase) REV1 REV1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1250 error-prone translesion synthesis [GO:0042276] GO:0003684; GO:0005634; GO:0016779; GO:0042276; GO:0046872 0 0 0 PF16589;PF00817;PF11799;PF16727; Q5RHP9 CHOYP_LOC100377578.1.1 m.63575 sp ERIC3_HUMAN 48.12 133 61 4 1 130 1 128 2.95E-33 126 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q5UR67 CHOYP_STERM_3136.1.1 m.53972 sp RIBX_MIMIV 39.726 146 83 2 318 458 22 167 2.95E-24 102 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q60675 CHOYP_LOC100863461.1.1 m.36477 sp LAMA2_MOUSE 27.327 333 220 9 5 326 2768 3089 2.95E-29 128 LAMA2_MOUSE reviewed Laminin subunit alpha-2 (Laminin M chain) (Laminin-12 subunit alpha) (Laminin-2 subunit alpha) (Laminin-4 subunit alpha) (Merosin heavy chain) Lama2 Mus musculus (Mouse) 3118 "axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; myelination in peripheral nervous system [GO:0022011]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; regulation of cell adhesion [GO:0030155]; regulation of cell migration [GO:0030334]; regulation of embryonic development [GO:0045995]" GO:0005576; GO:0005604; GO:0005605; GO:0007155; GO:0007411; GO:0022011; GO:0030155; GO:0030198; GO:0030334; GO:0032224; GO:0042383; GO:0043197; GO:0045995; GO:0070062 0 0 0 PF00052;PF00053;PF00054;PF02210;PF06008;PF06009;PF00055; Q6ZWR6 CHOYP_LOC100369255.3.3 m.52810 sp SYNE1_MOUSE 27.619 210 151 1 38 246 526 735 2.95E-25 107 SYNE1_MOUSE reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Syne1 Mus musculus (Mouse) 8799 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q7LFX5 CHOYP_CHST15.2.3 m.19629 sp CHSTF_HUMAN 41.287 373 206 5 115 478 191 559 2.95E-100 315 CHSTF_HUMAN reviewed Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) CHST15 BRAG GALNAC4S6ST KIAA0598 Homo sapiens (Human) 561 chondroitin sulfate biosynthetic process [GO:0030206]; hexose biosynthetic process [GO:0019319] GO:0000139; GO:0016021; GO:0019319; GO:0030206; GO:0050656; GO:0050659 0 0 0 0 Q7ZWY2 CHOYP_BRAFLDRAFT_287356.1.1 m.25008 sp PIHD1_XENLA 48.845 303 132 5 3 299 11 296 2.95E-101 301 PIHD1_XENLA reviewed PIH1 domain-containing protein 1 pih1d1 Xenopus laevis (African clawed frog) 297 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355 0 0 0 PF08190; Q865F7 CHOYP_BRAFLDRAFT_120908.1.1 m.5866 sp FABPH_MYOLU 34.074 135 84 2 6 139 1 131 2.95E-21 85.9 FABPH_MYOLU reviewed "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP)" FABP3 Myotis lucifugus (Little brown bat) 133 hibernation [GO:0042750] GO:0005215; GO:0005737; GO:0008289; GO:0042750 0 0 0 PF00061; Q86XL3 CHOYP_LOC100728743.1.1 m.53572 sp ANKL2_HUMAN 44.66 412 205 6 7 402 214 618 2.95E-110 367 ANKL2_HUMAN reviewed Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) ANKLE2 KIAA0692 LEM4 Homo sapiens (Human) 938 cell division [GO:0051301]; central nervous system development [GO:0007417]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of catalytic activity [GO:0050790] GO:0005789; GO:0007067; GO:0007084; GO:0007417; GO:0008601; GO:0016020; GO:0030176; GO:0035307; GO:0042326; GO:0043066; GO:0050790; GO:0051301; GO:0051721 0 0 0 PF01693;PF03020; Q8CDI7 CHOYP_LOC586463.1.1 m.20323 sp CC150_MOUSE 31.208 298 205 0 85 382 768 1065 2.95E-33 137 CC150_MOUSE reviewed Coiled-coil domain-containing protein 150 Ccdc150 Mus musculus (Mouse) 1110 0 0 0 0 0 0 Q8K4G1 CHOYP_LOC100635497.1.3 m.2616 sp LTBP4_MOUSE 36.533 375 175 16 2 363 744 1068 2.95E-47 175 LTBP4_MOUSE reviewed Latent-transforming growth factor beta-binding protein 4 (LTBP-4) Ltbp4 Mus musculus (Mouse) 1666 hormone secretion [GO:0046879]; regulation of proteolysis [GO:0030162]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005509; GO:0005578; GO:0005615; GO:0007179; GO:0030162; GO:0031012; GO:0046879; GO:0050431; GO:0070062 0 0 0 PF07645;PF00683; Q8VIK5 CHOYP_LOC101155369.1.1 m.39828 sp PEAR1_MOUSE 36.43 409 226 20 1 399 264 648 2.95E-50 186 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q92197 CHOYP_CHS1.1.4 m.4755 sp CHSC_ASPFU 26.667 420 235 15 808 1155 354 772 2.95E-22 108 CHSC_ASPFU reviewed Chitin synthase C (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase C) (Class-III chitin synthase C) chsC AFUA_5G00760 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) 893 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0071555 0 0 0 PF01644;PF08407; Q96BD0 CHOYP_SLCO4A1.2.4 m.25917 sp SO4A1_HUMAN 50.22 227 97 5 11 223 52 276 2.95E-57 196 SO4A1_HUMAN reviewed Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) SLCO4A1 OATP1 OATP4A1 OATPE SLC21A12 Homo sapiens (Human) 722 sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327] GO:0005886; GO:0005887; GO:0015347; GO:0015349; GO:0042403; GO:0043252; GO:0070327 0 0 cd06174; PF07648;PF03137; Q9CPV5 CHOYP_LOC575648.1.1 m.14604 sp PMF1_MOUSE 34.307 137 87 1 53 189 54 187 2.95E-20 87.8 PMF1_MOUSE reviewed Polyamine-modulated factor 1 (PMF-1) Pmf1 Mus musculus (Mouse) 202 "cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000444; GO:0003713; GO:0005654; GO:0006351; GO:0006355; GO:0007059; GO:0007067; GO:0043522; GO:0051301 0 0 0 PF03980; Q9EQG6 CHOYP_TVAG_096770.1.2 m.3227 sp KDIS_RAT 35.659 258 155 8 829 1079 70 323 2.95E-27 124 KDIS_RAT reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) Kidins220 Arms Rattus norvegicus (Rat) 1762 activation of MAPKK activity [GO:0000186]; cellular response to nerve growth factor stimulus [GO:1990090]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976] GO:0000186; GO:0005770; GO:0005829; GO:0010976; GO:0016021; GO:0019887; GO:0019901; GO:0030165; GO:0038180; GO:0043234; GO:1990090 0 0 0 PF12796;PF07693; Q9ES88 CHOYP_LOC101073750.1.1 m.56181 sp S13A2_MOUSE 43.455 573 288 13 39 599 35 583 2.95E-139 422 S13A2_MOUSE reviewed Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) Slc13a2 Nadc1 Sdct1 Mus musculus (Mouse) 586 0 GO:0005887; GO:0015361; GO:0070062 0 0 0 PF00939; Q9HC56 CHOYP_PCDH9.5.5 m.59487 sp PCDH9_HUMAN 32.628 803 497 22 8 796 6 778 2.95E-101 350 PCDH9_HUMAN reviewed Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0030426; GO:0030900; GO:0044291 0 0 0 PF00028;PF08266;PF08374; Q9NUV9 CHOYP_ZGC_113625.2.2 m.57655 sp GIMA4_HUMAN 37.338 308 169 7 51 346 31 326 2.95E-55 186 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9QXM1 CHOYP_JMY.1.1 m.4198 sp JMY_MOUSE 31.368 475 313 4 62 525 219 691 2.95E-71 251 JMY_MOUSE reviewed Junction-mediating and -regulatory protein Jmy Mus musculus (Mouse) 983 'de novo' actin filament nucleation [GO:0070060]; actin polymerization-dependent cell motility [GO:0070358]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell cycle arrest [GO:0007050]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0003713; GO:0005634; GO:0005737; GO:0005856; GO:0006281; GO:0006357; GO:0007050; GO:0031252; GO:0034314; GO:0043065; GO:0043620; GO:0051091; GO:0070060; GO:0070358; GO:0072332 0 0 0 PF15871;PF15920; Q9VCA8 CHOYP_LOC100637968.4.12 m.20487 sp ANKHM_DROME 35.254 295 170 11 33 314 622 908 2.95E-35 139 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9W735 CHOYP_LOC100374504.2.2 m.56927 sp PRM1A_DANRE 27.566 867 562 24 8 851 3 826 2.95E-95 321 PRM1A_DANRE reviewed Prominin-1-A (Prominin-like protein 1) prom1a proml1 Danio rerio (Zebrafish) (Brachydanio rerio) 826 0 GO:0005783; GO:0005793; GO:0005886; GO:0016021; GO:0016324; GO:0031528 0 0 0 PF05478; Q9WTP7 CHOYP_BRAFLDRAFT_61507.1.1 m.52347 sp KAD3_MOUSE 63.208 212 78 0 28 239 5 216 2.95E-97 286 KAD3_MOUSE reviewed "GTP:AMP phosphotransferase AK3, mitochondrial (EC 2.7.4.10) (Adenylate kinase 3) (AK 3) (Adenylate kinase 3 alpha-like 1)" Ak3 Ak3l Ak3l1 Akl3l Mus musculus (Mouse) 227 ADP biosynthetic process [GO:0006172]; AMP metabolic process [GO:0046033]; GTP metabolic process [GO:0046039]; ITP metabolic process [GO:0046041]; UTP metabolic process [GO:0046051] GO:0004017; GO:0005524; GO:0005525; GO:0005739; GO:0005759; GO:0006172; GO:0046033; GO:0046039; GO:0046041; GO:0046051; GO:0046899 0 0 cd01428; PF05191; Q9Z1L5 CHOYP_CA2D3.1.1 m.41662 sp CA2D3_MOUSE 32.3 1161 621 36 58 1180 35 1068 2.95E-162 514 CA2D3_MOUSE reviewed Voltage-dependent calcium channel subunit alpha-2/delta-3 (Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3] Cacna2d3 Mus musculus (Mouse) 1091 calcium ion transmembrane transport [GO:0070588]; regulation of calcium ion transport [GO:0051924] GO:0005244; GO:0005246; GO:0005262; GO:0005891; GO:0046872; GO:0051924; GO:0070588 0 0 0 PF08473;PF13768;PF08399; B7U179 CHOYP_NEMVEDRAFT_V1G248552.1.1 m.39777 sp ABAP1_ARATH 25.688 109 81 0 6 114 561 669 2.96E-10 63.2 ABAP1_ARATH reviewed ARMADILLO BTB ARABIDOPSIS PROTEIN 1 (ABAP1) ABAP1 At5g13060 T19L5.20 Arabidopsis thaliana (Mouse-ear cress) 737 DNA-dependent DNA replication [GO:0006261]; negative regulation of cell proliferation [GO:0008285]; negative regulation of DNA-dependent DNA replication [GO:2000104]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127] GO:0005634; GO:0005737; GO:0006261; GO:0008285; GO:0016567; GO:0031261; GO:0042127; GO:2000104 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00514;PF00651; C5BMZ8 CHOYP_TOL2_C08810.1.1 m.6377 sp BIOHC_TERTT 26.606 218 115 9 7 204 303 495 2.96E-12 70.1 BIOHC_TERTT reviewed Biotin biosynthesis bifunctional protein BioHC [Includes: Carboxylesterase BioH (EC 3.1.1.1) (Biotin synthesis protein BioH); Malonyl-[acyl-carrier protein] O-methyltransferase (Malonyl-ACP O-methyltransferase) (EC 2.1.1.197) (Biotin synthesis protein BioC)] bioC TERTU_0492 Teredinibacter turnerae (strain ATCC 39867 / T7901) 570 biotin biosynthetic process [GO:0009102] GO:0009102; GO:0010340; GO:0052689 PATHWAY: Cofactor biosynthesis; biotin biosynthesis. 0 0 PF12697;PF08241; D2GXS7 CHOYP_BRAFLDRAFT_88217.13.14 m.61722 sp TRIM2_AILME 31.41 156 98 4 351 500 578 730 2.96E-11 69.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14795 CHOYP_AGAP_AGAP000065.1.1 m.15468 sp UN13B_HUMAN 66.406 128 33 4 84 209 406 525 2.96E-48 172 UN13B_HUMAN reviewed Protein unc-13 homolog B (Munc13-2) (munc13) UNC13B UNC13 Homo sapiens (Human) 1591 "apoptotic process [GO:0006915]; chemical synaptic transmission [GO:0007268]; excretion [GO:0007588]; glutamate secretion [GO:0014047]; innervation [GO:0060384]; intracellular signal transduction [GO:0035556]; neuromuscular junction development [GO:0007528]; neurotransmitter secretion [GO:0007269]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic vesicle priming [GO:0010808]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; signal transduction [GO:0007165]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle docking [GO:0016081]; synaptic vesicle priming [GO:0016082]" GO:0004871; GO:0004872; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0006915; GO:0007165; GO:0007268; GO:0007269; GO:0007528; GO:0007588; GO:0010808; GO:0014047; GO:0016081; GO:0016082; GO:0019992; GO:0030054; GO:0031594; GO:0035249; GO:0035556; GO:0043195; GO:0046872; GO:0048172; GO:0048786; GO:0060384; GO:0097151 0 0 0 PF00130;PF00168;PF06292;PF10540; O18276 CHOYP_BRAFLDRAFT_206516.1.1 m.8378 sp GBRB_CAEEL 26.829 123 86 2 62 180 74 196 2.96E-09 58.5 GBRB_CAEEL reviewed Gamma-aminobutyric acid receptor subunit beta (GABA(A) receptor subunit beta) gab-1 ZC482.1 Caenorhabditis elegans 550 chemical synaptic transmission [GO:0007268]; ion transport [GO:0006811] GO:0004890; GO:0005230; GO:0005254; GO:0006811; GO:0007268; GO:0030054; GO:0034707; GO:0045202; GO:0045211; GO:1902711 0 0 0 PF02931;PF02932; O18973 CHOYP_RABX5.2.2 m.44995 sp RABX5_BOVIN 47.938 388 189 7 37 416 106 488 2.96E-121 365 RABX5_BOVIN reviewed Rab5 GDP/GTP exchange factor (Rabex-5) RABGEF1 RABEX5 Bos taurus (Bovine) 492 endocytosis [GO:0006897]; protein transport [GO:0015031] GO:0003677; GO:0005769; GO:0006897; GO:0008270; GO:0015031; GO:0055037 0 0 0 PF02204;PF01754; O57460 CHOYP_LOC100898124.1.1 m.49610 sp TLL1_DANRE 23.675 283 188 11 103 375 350 614 2.96E-08 59.7 TLL1_DANRE reviewed Dorsal-ventral patterning tolloid-like protein 1 (EC 3.4.24.-) (Mini fin protein) tll1 mfn tld tolloid Danio rerio (Zebrafish) (Brachydanio rerio) 1022 blood vessel development [GO:0001568]; determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; embryonic caudal fin morphogenesis [GO:0035124]; embryonic hemopoiesis [GO:0035162]; endothelial cell development [GO:0001885]; mesoderm formation [GO:0001707]; positive regulation of BMP signaling pathway [GO:0030513]; post-anal tail morphogenesis [GO:0036342]; proteolysis [GO:0006508] GO:0001568; GO:0001707; GO:0001885; GO:0004222; GO:0005509; GO:0005576; GO:0006508; GO:0008233; GO:0008237; GO:0008270; GO:0009953; GO:0030513; GO:0035124; GO:0035162; GO:0036342; GO:0048264 0 0 0 PF01400;PF00431; O75382 CHOYP_TRIM3.25.58 m.32741 sp TRIM3_HUMAN 24.723 271 176 9 205 459 486 744 2.96E-10 66.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06782 CHOYP_CHRO.50305.1.1 m.45648 sp SNF1_YEAST 31.364 220 123 4 255 462 43 246 2.96E-20 98.6 SNF1_YEAST reviewed Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) SNF1 CAT1 CCR1 GLC2 PAS14 YDR477W D8035.20 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 633 carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; cellular response to nitrogen starvation [GO:0006995]; fungal-type cell wall assembly [GO:0071940]; intracellular signal transduction [GO:0035556]; invasive growth in response to glucose limitation [GO:0001403]; negative regulation of translation [GO:0017148]; positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [GO:1900436]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of macroautophagy [GO:0016239]; protein phosphorylation [GO:0006468]; pseudohyphal growth [GO:0007124]; replicative cell aging [GO:0001302]; response to unfolded protein [GO:0006986]; single-species surface biofilm formation [GO:0090606] GO:0000324; GO:0001302; GO:0001403; GO:0004674; GO:0004679; GO:0005086; GO:0005524; GO:0005634; GO:0005641; GO:0005737; GO:0005975; GO:0006468; GO:0006986; GO:0006995; GO:0007124; GO:0007155; GO:0016239; GO:0017148; GO:0031588; GO:0031965; GO:0035556; GO:0045722; GO:0071940; GO:0090606; GO:1900436 0 0 cd14334; PF16579;PF00069;PF08587; P0DO97 CHOYP_LOC579454.1.1 m.10488 sp CC192_HUMAN 32.022 178 113 4 96 271 82 253 2.96E-06 52.8 CC192_HUMAN reviewed Coiled-coil domain-containing protein 192 CCDC192 LINC01183 Homo sapiens (Human) 292 0 0 0 0 0 0 P16157 CHOYP_LOC762964.5.10 m.39357 sp ANK1_HUMAN 29.895 475 272 7 20 458 139 588 2.96E-51 190 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22105 CHOYP_LOC100641827.2.2 m.37752 sp TENX_HUMAN 43.519 216 110 7 109 317 4021 4231 2.96E-57 202 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P52786 CHOYP_CP2J5.1.1 m.38461 sp CP2J1_RABIT 28.513 491 323 10 9 483 21 499 2.96E-53 190 CP2J1_RABIT reviewed Cytochrome P450 2J1 (EC 1.14.14.1) (CYPIIJ1) (Cytochrome P-450IB) CYP2J1 Oryctolagus cuniculus (Rabbit) 501 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P61354 CHOYP_LOC100373506.8.8 m.50244 sp RL27_RAT 77.778 90 20 0 4 93 32 121 2.96E-47 150 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; P62332 CHOYP_ARF6.1.2 m.3974 sp ARF6_RAT 94.286 175 10 0 1 175 1 175 2.96E-124 349 ARF6_RAT reviewed ADP-ribosylation factor 6 Arf6 Rattus norvegicus (Rat) 175 actin cytoskeleton organization [GO:0030036]; cortical actin cytoskeleton organization [GO:0030866]; establishment of epithelial cell polarity [GO:0090162]; hepatocyte apoptotic process [GO:0097284]; liver development [GO:0001889]; myeloid cell apoptotic process [GO:0033028]; negative regulation of dendrite development [GO:2000171]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; protein localization to cell surface [GO:0034394]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of Rac protein signal transduction [GO:0035020]; ruffle organization [GO:0031529]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0001726; GO:0001889; GO:0005525; GO:0005769; GO:0005794; GO:0005886; GO:0005925; GO:0005938; GO:0007264; GO:0015031; GO:0016192; GO:0030036; GO:0030139; GO:0030838; GO:0030866; GO:0031527; GO:0031529; GO:0033028; GO:0034394; GO:0035020; GO:0036010; GO:0043209; GO:0051489; GO:0055037; GO:0055038; GO:0060998; GO:0070062; GO:0090004; GO:0090162; GO:0097284; GO:2000171 0 0 0 PF00025; P62332 CHOYP_ARF6.2.2 m.10048 sp ARF6_RAT 94.286 175 10 0 1 175 1 175 2.96E-124 349 ARF6_RAT reviewed ADP-ribosylation factor 6 Arf6 Rattus norvegicus (Rat) 175 actin cytoskeleton organization [GO:0030036]; cortical actin cytoskeleton organization [GO:0030866]; establishment of epithelial cell polarity [GO:0090162]; hepatocyte apoptotic process [GO:0097284]; liver development [GO:0001889]; myeloid cell apoptotic process [GO:0033028]; negative regulation of dendrite development [GO:2000171]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; protein localization to cell surface [GO:0034394]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; regulation of dendritic spine development [GO:0060998]; regulation of filopodium assembly [GO:0051489]; regulation of Rac protein signal transduction [GO:0035020]; ruffle organization [GO:0031529]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0001726; GO:0001889; GO:0005525; GO:0005769; GO:0005794; GO:0005886; GO:0005925; GO:0005938; GO:0007264; GO:0015031; GO:0016192; GO:0030036; GO:0030139; GO:0030838; GO:0030866; GO:0031527; GO:0031529; GO:0033028; GO:0034394; GO:0035020; GO:0036010; GO:0043209; GO:0051489; GO:0055037; GO:0055038; GO:0060998; GO:0070062; GO:0090004; GO:0090162; GO:0097284; GO:2000171 0 0 0 PF00025; Q02427 CHOYP_LOC100680210.1.1 m.5750 sp RBP1_DROME 70.886 79 23 0 38 116 3 81 2.96E-37 129 RBP1_DROME reviewed RNA-binding protein 1 Rbp1 Rbp11 CG17136 Drosophila melanogaster (Fruit fly) 144 "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of gene expression [GO:0010468]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0000398; GO:0001178; GO:0003729; GO:0005634; GO:0006376; GO:0008380; GO:0010468; GO:0031440; GO:0035327; GO:0045292 0 0 0 PF00076; Q10901 CHOYP_AAAT.1.1 m.43421 sp EAA1_CAEEL 36.752 468 275 5 22 483 16 468 2.96E-103 321 EAA1_CAEEL reviewed Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) glt-1 C12D12.2 Caenorhabditis elegans 503 0 GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0042995 0 0 0 PF00375; Q13023 CHOYP_LOC100747581.1.1 m.9744 sp AKAP6_HUMAN 23.79 248 151 9 119 339 961 1197 2.96E-08 62 AKAP6_HUMAN reviewed A-kinase anchor protein 6 (AKAP-6) (A-kinase anchor protein 100 kDa) (AKAP 100) (Protein kinase A-anchoring protein 6) (PRKA6) (mAKAP) AKAP6 AKAP100 KIAA0311 Homo sapiens (Human) 2319 action potential [GO:0001508]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cytokine stimulus [GO:0071345]; intracellular signal transduction [GO:0035556]; negative regulation of cAMP biosynthetic process [GO:0030818]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell growth [GO:0030307]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of potassium ion transmembrane transport [GO:1901381]; positive regulation of protein phosphatase type 2B activity [GO:0032514]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; protein targeting [GO:0006605]; regulation of membrane repolarization [GO:0060306]; regulation of protein kinase A signaling [GO:0010738]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880] GO:0001508; GO:0005635; GO:0005737; GO:0005901; GO:0006605; GO:0008179; GO:0010738; GO:0010880; GO:0014701; GO:0014704; GO:0016529; GO:0019933; GO:0030307; GO:0030315; GO:0030818; GO:0031965; GO:0032514; GO:0032947; GO:0034237; GO:0034704; GO:0035556; GO:0043495; GO:0044325; GO:0048471; GO:0051018; GO:0051281; GO:0051533; GO:0060306; GO:0060316; GO:0061051; GO:0070886; GO:0071320; GO:0071345; GO:1901381; GO:1902261 0 0 0 0 Q3MHZ8 CHOYP_LOC100186936.2.2 m.33292 sp LEG9_BOVIN 38.123 341 165 10 1 306 25 354 2.96E-60 199 LEG9_BOVIN reviewed Galectin-9 (Gal-9) LGALS9 Bos taurus (Bovine) 355 immune system process [GO:0002376] GO:0002376; GO:0005576; GO:0005634; GO:0005737; GO:0030246 0 0 0 PF00337; Q4R9E0 CHOYP_LOC100313750.1.2 m.2580 sp TECT3_MACFA 30.149 335 168 16 367 693 308 584 2.96E-29 127 TECT3_MACFA reviewed Tectonic-3 TCTN3 TECT3 QtsA-10216 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 608 apoptotic process [GO:0006915]; cilium morphogenesis [GO:0060271]; smoothened signaling pathway [GO:0007224] GO:0006915; GO:0007224; GO:0016021; GO:0060271 0 0 0 PF07773; Q58DK5 CHOYP_HEM2.1.1 m.6789 sp HEM2_BOVIN 65.854 328 112 0 1 328 1 328 2.96E-170 479 HEM2_BOVIN reviewed Delta-aminolevulinic acid dehydratase (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) ALAD Bos taurus (Bovine) 329 cellular response to interleukin-4 [GO:0071353]; heme biosynthetic process [GO:0006783]; protein homooligomerization [GO:0051260]; protoporphyrinogen IX biosynthetic process [GO:0006782] GO:0004655; GO:0005634; GO:0005829; GO:0006782; GO:0006783; GO:0008270; GO:0032791; GO:0051260; GO:0070062; GO:0071353 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. 0 0 PF00490; Q5RFE6 CHOYP_THNS2.1.1 m.27131 sp THNS2_PONAB 49.474 475 234 3 1 471 1 473 2.96E-173 498 THNS2_PONAB reviewed Threonine synthase-like 2 (TSH2) (EC 4.2.3.-) THNSL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 484 0 GO:0016829 0 0 0 PF00291;PF14821; Q5U2U0 CHOYP_CLPX.1.2 m.12748 sp CLPX_RAT 41.873 566 260 15 51 563 55 604 2.96E-120 372 CLPX_RAT reviewed "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial" Clpx Rattus norvegicus (Rat) 633 protein catabolic process [GO:0030163]; protein folding [GO:0006457]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004176; GO:0005524; GO:0005654; GO:0005743; GO:0005759; GO:0006457; GO:0006508; GO:0009368; GO:0009841; GO:0016504; GO:0030163; GO:0042645; GO:0046872; GO:0051603 0 0 0 PF07724;PF10431; Q5VZK9 CHOYP_LR16A.2.3 m.41105 sp CARL1_HUMAN 42.515 334 189 2 57 390 14 344 2.96E-83 280 CARL1_HUMAN reviewed "F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)" LRRC16A CARMIL CARMIL1 LRRC16 Homo sapiens (Human) 1371 actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; barbed-end actin filament uncapping [GO:0051638]; blood coagulation [GO:0007596]; cell migration [GO:0016477]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415] GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007015; GO:0007596; GO:0016477; GO:0030027; GO:0030032; GO:0030335; GO:0030838; GO:0031252; GO:0031529; GO:0031941; GO:0032403; GO:0044351; GO:0044354; GO:0046415; GO:0051496; GO:0051638; GO:0051639; GO:0070062; GO:1900026; GO:1902745; GO:2000813 0 0 0 PF16000;PF13516; Q6RKD8 CHOYP_PHUM_PHUM136240.1.1 m.64301 sp FLRT1_MOUSE 29.915 117 76 4 2 116 271 383 2.96E-06 50.1 FLRT1_MOUSE reviewed Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin leucine rich transmembrane protein 1) Flrt1 Mus musculus (Mouse) 674 cell adhesion [GO:0007155]; cytokine-mediated signaling pathway [GO:0019221]; dendrite development [GO:0016358]; fibroblast growth factor receptor signaling pathway [GO:0008543]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965] GO:0004860; GO:0005104; GO:0005615; GO:0005789; GO:0005887; GO:0005911; GO:0005925; GO:0006469; GO:0007155; GO:0008543; GO:0016358; GO:0019221; GO:0030659; GO:0031410; GO:0032809; GO:0044306; GO:0046426; GO:0048471; GO:0051965; GO:1990138 0 0 0 PF13855;PF01462; Q7T0W1 CHOYP_BRAFLDRAFT_113602.1.1 m.10824 sp BOP1A_XENLA 64.655 348 112 3 1 348 392 728 2.96E-167 486 BOP1A_XENLA reviewed Ribosome biogenesis protein bop1-A (Block of proliferation 1 protein A) bop1-a Xenopus laevis (African clawed frog) 728 "maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; regulation of cell cycle [GO:0051726]" GO:0000463; GO:0000466; GO:0005654; GO:0030687; GO:0043021; GO:0051726; GO:0070545 0 0 0 PF08145;PF00400; Q80T91 CHOYP_MEGF6.50.59 m.51660 sp MEG11_MOUSE 37.883 359 194 17 196 552 146 477 2.96E-49 188 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8C3X2 CHOYP_LOC100671315.1.1 m.2758 sp CC90B_MOUSE 39.614 207 104 2 98 286 50 253 2.96E-38 138 CC90B_MOUSE reviewed "Coiled-coil domain-containing protein 90B, mitochondrial" Ccdc90b Mus musculus (Mouse) 256 0 GO:0005739; GO:0016021; GO:0031966 0 0 0 PF07798; Q8IRC7 CHOYP_AWH.1.2 m.9933 sp AWH_DROME 65.566 212 68 1 38 244 1 212 2.96E-98 292 AWH_DROME reviewed LIM/homeobox protein Awh (Protein arrowhead) Awh CG1072 Drosophila melanogaster (Fruit fly) 275 "compound eye development [GO:0048749]; imaginal disc development [GO:0007444]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0007444; GO:0008270; GO:0010468; GO:0048749 0 0 0 PF00046;PF00412; Q8IWZ3 CHOYP_LOC100641396.11.27 m.37678 sp ANKH1_HUMAN 32.724 492 275 16 7 481 242 694 2.96E-46 177 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8R2L5 CHOYP_NEMVEDRAFT_V1G198846.1.1 m.25649 sp RT18C_MOUSE 49.438 89 37 2 157 245 57 137 2.96E-18 81.6 RT18C_MOUSE reviewed "28S ribosomal protein S18c, mitochondrial (MRP-S18-c) (Mrps18-c) (S18mt-c) (28S ribosomal protein S18-1, mitochondrial) (MRP-S18-1)" Mrps18c Mus musculus (Mouse) 143 mitochondrial translation [GO:0032543] GO:0003735; GO:0005739; GO:0005763; GO:0022627; GO:0032543 0 0 0 PF01084; Q9I7U4 CHOYP_LOC100367089.1.4 m.1389 sp TITIN_DROME 26.26 655 373 21 102 663 16499 17136 2.96E-39 164 TITIN_DROME reviewed Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) 18141 cell division [GO:0051301]; locomotion [GO:0040011]; mesoderm development [GO:0007498]; mitotic chromosome condensation [GO:0007076]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; regulation of hemocyte proliferation [GO:0035206]; sarcomere organization [GO:0045214]; sensory perception of pain [GO:0019233]; sister chromatid cohesion [GO:0007062]; skeletal muscle tissue development [GO:0007519]; somatic muscle development [GO:0007525]; visceral muscle development [GO:0007522] GO:0000794; GO:0003779; GO:0005863; GO:0005875; GO:0007062; GO:0007076; GO:0007498; GO:0007517; GO:0007519; GO:0007520; GO:0007522; GO:0007525; GO:0008307; GO:0016203; GO:0019233; GO:0030017; GO:0030018; GO:0031674; GO:0035206; GO:0040011; GO:0045214; GO:0051301 0 0 0 PF06582;PF00041;PF07679;PF00018; Q9NTG1 CHOYP_LOC100368614.2.3 m.31971 sp PKDRE_HUMAN 24.938 1215 782 31 2681 3833 1096 2242 2.96E-98 360 PKDRE_HUMAN reviewed Polycystic kidney disease and receptor for egg jelly-related protein (PKD and REJ homolog) PKDREJ Homo sapiens (Human) 2253 acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0007340; GO:0016020; GO:0016021; GO:0050982 0 0 0 PF08016;PF01477;PF02010; Q9VFB2 CHOYP_RT10.4.4 m.65184 sp RT10_DROME 45.89 146 72 2 48 188 25 168 2.96E-36 134 RT10_DROME reviewed "28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt)" mRpS10 CG4247 Drosophila melanogaster (Fruit fly) 173 sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005763; GO:0006412; GO:0019233 0 0 0 PF00338; Q9Y2I1 CHOYP_NISCH.2.2 m.26901 sp NISCH_HUMAN 49.451 91 46 0 1 91 382 472 2.96E-20 90.1 NISCH_HUMAN reviewed Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) NISCH IRAS KIAA0975 Homo sapiens (Human) 1504 "actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; glucose metabolic process [GO:0006006]; negative regulation of cell migration [GO:0030336]; norepinephrine secretion [GO:0048243]; Rac protein signal transduction [GO:0016601]; regulation of blood pressure [GO:0008217]; regulation of synaptic transmission, GABAergic [GO:0032228]" GO:0005769; GO:0005829; GO:0005886; GO:0006006; GO:0006915; GO:0008217; GO:0016020; GO:0016601; GO:0030036; GO:0030336; GO:0032228; GO:0035091; GO:0042802; GO:0048243; GO:0055037 0 0 0 PF00787; A4IF63 CHOYP_BRAFLDRAFT_87288.3.5 m.20525 sp TRIM2_BOVIN 35.366 82 51 2 27 107 627 707 2.97E-07 50.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6H584 CHOYP_LOC100709262.2.2 m.61238 sp CO6A5_MOUSE 35.345 116 67 5 14 126 930 1040 2.97E-11 62.8 CO6A5_MOUSE reviewed Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) Col6a5 Col29a1 Gm7455 Mus musculus (Mouse) 2640 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; D3ZVM4 CHOYP_LOC100374741.19.83 m.20585 sp LIN41_RAT 20.063 638 345 24 25 518 199 815 2.97E-10 66.6 LIN41_RAT reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) Trim71 Lin41 Rattus norvegicus (Rat) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; E1C7T6 CHOYP_TRIADDRAFT_56963.1.1 m.16322 sp TYW5_CHICK 29.787 235 138 7 84 295 26 256 2.97E-16 82.8 TYW5_CHICK reviewed tRNA wybutosine-synthesizing protein 5 (EC 1.14.11.42) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase) TYW5 Gallus gallus (Chicken) 318 wybutosine biosynthetic process [GO:0031591] GO:0000049; GO:0005506; GO:0016706; GO:0031591; GO:0042803 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 0 O18334 CHOYP_RAB6B.1.1 m.24945 sp RAB6_DROME 87.006 177 21 2 1 176 33 208 2.97E-109 313 RAB6_DROME reviewed Ras-related protein Rab6 (Protein warthog) Rab6 wrt CG6601 Drosophila melanogaster (Fruit fly) 208 "axon guidance [GO:0007411]; compound eye morphogenesis [GO:0001745]; defense response to fungus [GO:0050832]; exocytosis [GO:0006887]; germarium-derived egg chamber formation [GO:0007293]; intra-Golgi vesicle-mediated transport [GO:0006891]; oocyte microtubule cytoskeleton polarization [GO:0008103]; photoreceptor cell maintenance [GO:0045494]; phototransduction [GO:0007602]; pole plasm oskar mRNA localization [GO:0045451]; R7 cell development [GO:0045467]; Rab protein signal transduction [GO:0032482]; regulation of postsynaptic membrane potential [GO:0060078]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle-mediated transport [GO:0016192]" GO:0000139; GO:0001745; GO:0003924; GO:0005525; GO:0005794; GO:0005829; GO:0006887; GO:0006890; GO:0006891; GO:0007293; GO:0007411; GO:0007602; GO:0008103; GO:0016023; GO:0016192; GO:0030054; GO:0031982; GO:0032482; GO:0042147; GO:0043025; GO:0043204; GO:0045202; GO:0045451; GO:0045467; GO:0045494; GO:0050832; GO:0060078 0 0 0 PF00071; O73853 CHOYP_LOC100371043.5.5 m.49018 sp CP17A_ICTPU 33.724 427 256 9 31 448 31 439 2.97E-73 242 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; P02553 CHOYP_TBA.2.6 m.22413 sp TBA_LYTPI 52.941 136 20 4 41 170 4 101 2.97E-36 126 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P58365 CHOYP_CAD23.1.1 m.3802 sp CAD23_RAT 33.017 633 384 22 1 613 2109 2721 2.97E-62 227 CAD23_RAT reviewed Cadherin-23 (Otocadherin) Cdh23 Rattus norvegicus (Rat) 3317 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0005509; GO:0005886; GO:0007156; GO:0007605; GO:0007626; GO:0016021; GO:0032420; GO:0045177; GO:0047485; GO:0060122 0 0 0 PF00028; P62083 CHOYP_RS7.3.9 m.17929 sp RS7_RAT 83.929 168 25 2 26 191 1 168 2.97E-97 284 RS7_RAT reviewed 40S ribosomal protein S7 (S8) Rps7 Rattus norvegicus (Rat) 194 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0003735; GO:0005815; GO:0006364; GO:0006412; GO:0008266; GO:0022627; GO:0030686; GO:0032040; GO:0042274 0 0 0 PF01251; P80601 CHOYP_BRAFLDRAFT_118789.3.3 m.62894 sp UK114_CAPHI 69.291 127 39 0 19 145 6 132 2.97E-58 180 UK114_CAPHI reviewed Ribonuclease UK114 (EC 3.1.-.-) (14.3 kDa perchloric acid soluble protein) (14.5 kDa translational inhibitor protein) (UK114 antigen) HRSP12 Capra hircus (Goat) 137 0 GO:0004519; GO:0009986 0 0 0 PF01042; Q02357 CHOYP_TVAG_067900.7.7 m.54138 sp ANK1_MOUSE 34.387 253 143 4 136 386 198 429 2.97E-29 123 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q0DV28 CHOYP_BRAFLDRAFT_130981.1.3 m.3345 sp ARK1_ORYSJ 28.188 149 97 3 8 154 701 841 2.97E-06 52.8 ARK1_ORYSJ reviewed Armadillo repeat-containing kinesin-like protein 1 Os03g0152900 LOC_Os03g05820 Oryza sativa subsp. japonica (Rice) 945 cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; protein localization [GO:0008104]; regulation of microtubule-based process [GO:0032886]; root development [GO:0048364] GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0008104; GO:0008574; GO:0030705; GO:0032886; GO:0048364 0 0 0 PF00514;PF00225; Q13702 CHOYP_RAPSN.1.1 m.43382 sp RAPSN_HUMAN 34.642 433 251 8 1 425 1 409 2.97E-74 241 RAPSN_HUMAN reviewed 43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein) (RING finger protein 205) RAPSN RNF205 Homo sapiens (Human) 412 "chemical synaptic transmission [GO:0007268]; positive regulation of neuromuscular synaptic transmission [GO:1900075]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of postsynaptic membrane organization [GO:1901626]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synaptic transmission, cholinergic [GO:0007271]" GO:0005794; GO:0005856; GO:0007268; GO:0007271; GO:0008270; GO:0030054; GO:0031594; GO:0033130; GO:0043525; GO:0045211; GO:0071340; GO:1900075; GO:1901626 0 0 0 PF10579;PF13639; Q14160 CHOYP_BRAFLDRAFT_126447.2.3 m.7140 sp SCRIB_HUMAN 31.25 160 103 2 262 421 34 186 2.97E-10 67 SCRIB_HUMAN reviewed Protein scribble homolog (Scribble) (hScrib) (Protein LAP4) SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL Homo sapiens (Human) 1630 activation of GTPase activity [GO:0090630]; apoptotic process involved in morphogenesis [GO:0060561]; astrocyte cell migration [GO:0043615]; asymmetric protein localization [GO:0008105]; auditory receptor cell stereocilium organization [GO:0060088]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cochlear nucleus development [GO:0021747]; establishment of apical/basal cell polarity [GO:0035089]; mammary gland duct morphogenesis [GO:0060603]; negative regulation of mitotic cell cycle [GO:0045930]; neural tube closure [GO:0001843]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; positive regulation of receptor recycling [GO:0001921]; protein localization to adherens junction [GO:0071896]; single organismal cell-cell adhesion [GO:0016337]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle targeting [GO:0016080]; viral process [GO:0016032]; wound healing [GO:0042060] GO:0001843; GO:0001921; GO:0005654; GO:0005737; GO:0005886; GO:0005911; GO:0005913; GO:0008105; GO:0008283; GO:0016032; GO:0016080; GO:0016323; GO:0016337; GO:0016477; GO:0021747; GO:0030027; GO:0030054; GO:0034750; GO:0035089; GO:0035748; GO:0042060; GO:0043065; GO:0043615; GO:0045930; GO:0048488; GO:0050918; GO:0060088; GO:0060561; GO:0060603; GO:0070062; GO:0071896; GO:0090630; GO:0098641; GO:0098793 0 0 0 PF13855;PF00595; Q16RX1 CHOYP_MED21.1.1 m.6955 sp MED21_AEDAE 65.414 133 46 0 1 133 1 133 2.97E-57 177 MED21_AEDAE reviewed Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) MED21 AAEL010797 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 141 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11221; Q26636 CHOYP_LOC575203.4.6 m.16405 sp CATL_SARPE 62.121 264 91 4 1 256 77 339 2.97E-117 342 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q28FY0 CHOYP_LOC586953.1.1 m.19600 sp TILB_XENTR 52.34 470 211 5 1 458 1 469 2.97E-160 464 TILB_XENTR reviewed Protein tilB homolog (Leucine-rich repeat-containing protein 6) lrrc6 TGas012h22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 470 cilium movement [GO:0003341] GO:0003341; GO:0005737; GO:0005929 0 0 0 0 Q2HJ56 CHOYP_BRAFLDRAFT_275517.1.1 m.9720 sp PWP1_BOVIN 46.234 478 228 7 4 464 7 472 2.97E-144 427 PWP1_BOVIN reviewed Periodic tryptophan protein 1 homolog PWP1 Bos taurus (Bovine) 500 0 GO:0005730; GO:0005794 0 0 0 PF00400; Q54DF2 CHOYP_LOC582059.1.1 m.62235 sp MRKA_DICDI 40.684 263 143 7 23 279 106 361 2.97E-55 195 MRKA_DICDI reviewed Probable serine/threonine-protein kinase MARK-A (EC 2.7.11.1) mrkA DDB_G0292304 Dictyostelium discoideum (Slime mold) 1060 establishment of cell polarity [GO:0030010]; microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0004674; GO:0005524; GO:0030010 0 0 0 PF02149;PF00069; Q5XI68 CHOYP_BRAFLDRAFT_68934.2.2 m.62962 sp NC2B_RAT 71.127 142 41 0 4 145 1 142 2.97E-68 207 NC2B_RAT reviewed Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) Dr1 Rattus norvegicus (Rat) 176 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF00808; Q6NZQ8 CHOYP_ISCW_ISCW008178.1.1 m.18990 sp MARH1_MOUSE 27.136 199 129 4 15 212 49 232 2.97E-13 70.9 MARH1_MOUSE reviewed E3 ubiquitin-protein ligase MARCH1 (EC 6.3.2.-) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) 1-Mar Mus musculus (Mouse) 289 antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0002495; GO:0004842; GO:0005764; GO:0005765; GO:0005768; GO:0005789; GO:0005886; GO:0006955; GO:0008270; GO:0016021; GO:0016874; GO:0030659; GO:0031901; GO:0031902; GO:0032588; GO:0042287; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q6NZQ8 CHOYP_LOC594533.1.1 m.58831 sp MARH1_MOUSE 27.136 199 129 4 15 212 49 232 2.97E-13 70.9 MARH1_MOUSE reviewed E3 ubiquitin-protein ligase MARCH1 (EC 6.3.2.-) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) 1-Mar Mus musculus (Mouse) 289 antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0002495; GO:0004842; GO:0005764; GO:0005765; GO:0005768; GO:0005789; GO:0005886; GO:0006955; GO:0008270; GO:0016021; GO:0016874; GO:0030659; GO:0031901; GO:0031902; GO:0032588; GO:0042287; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q6PAT0 CHOYP_LOC100018548.1.1 m.12983 sp ADAT3_MOUSE 34.317 271 161 5 11 268 29 295 2.97E-45 158 ADAT3_MOUSE reviewed Probable inactive tRNA-specific adenosine deaminase-like protein 3 (tRNA-specific adenosine-34 deaminase subunit ADAT3) Adat3 Mus musculus (Mouse) 349 RNA modification [GO:0009451]; tRNA processing [GO:0008033] GO:0003824; GO:0005829; GO:0008033; GO:0008270; GO:0009451 0 0 0 PF00383; Q6PAY6 CHOYP_PROD2.3.3 m.66841 sp PROD2_XENLA 43.772 281 155 2 1 281 173 450 2.97E-78 248 PROD2_XENLA reviewed Probable proline dehydrogenase 2 (EC 1.5.5.2) (Probable proline oxidase 2) prodh2 Xenopus laevis (African clawed frog) 466 proline catabolic process to glutamate [GO:0010133] GO:0004657; GO:0010133 PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2. 0 0 PF01619; Q6Q899 CHOYP_IFIH1.1.14 m.2408 sp DDX58_MOUSE 28.712 916 562 31 222 1084 20 897 2.97E-93 322 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6R5N8 CHOYP_BRAFLDRAFT_82677.1.1 m.61490 sp TLR13_MOUSE 26.625 323 191 10 47 343 673 975 2.97E-26 113 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q8CH87 CHOYP_LOC100370094.1.1 m.21314 sp GCNT3_RAT 30.458 371 220 10 92 431 68 431 2.97E-54 190 GCNT3_RAT reviewed "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (EC 2.4.1.102) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M) (dI/C2/C4GnT) (dIGnT)" Gcnt3 Rattus norvegicus (Rat) 437 immunoglobulin production in mucosal tissue [GO:0002426]; intestinal absorption [GO:0050892]; kidney morphogenesis [GO:0060993]; protein glycosylation [GO:0006486]; tissue morphogenesis [GO:0048729] GO:0000139; GO:0002426; GO:0003829; GO:0006486; GO:0008109; GO:0016021; GO:0047225; GO:0048729; GO:0050892; GO:0060993; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02485; Q8VIK1 CHOYP_LOC100701172.1.1 m.12959 sp SNR25_MOUSE 60.976 123 48 0 67 189 1 123 2.97E-49 158 SNR25_MOUSE reviewed U11/U12 small nuclear ribonucleoprotein 25 kDa protein (U11/U12 snRNP 25 kDa protein) Snrnp25 Mus musculus (Mouse) 123 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005634; GO:0005654; GO:0005689; GO:0005737; GO:0006397; GO:0008380; GO:0045171 0 0 0 0 Q92752 CHOYP_LOC100632478.2.2 m.61869 sp TENR_HUMAN 42.149 121 65 3 1 121 1211 1326 2.97E-25 103 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q96DM1 CHOYP_LOC101358792.2.2 m.48971 sp PGBD4_HUMAN 27.564 156 108 1 79 229 88 243 2.97E-11 65.9 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9D7H3 CHOYP_RTCA.1.1 m.16391 sp RTCA_MOUSE 55.903 288 125 1 38 323 4 291 2.97E-113 335 RTCA_MOUSE reviewed RNA 3'-terminal phosphate cyclase (RNA cyclase) (RNA-3'-phosphate cyclase) (EC 6.5.1.4) (RNA terminal phosphate cyclase domain-containing protein 1) RtcA Rpc1 Rtcd1 Mus musculus (Mouse) 366 RNA processing [GO:0006396] GO:0003723; GO:0003963; GO:0005524; GO:0005634; GO:0005654; GO:0006396; GO:0044822 0 0 0 PF01137;PF05189; Q9ERD9 CHOYP_BRAFLDRAFT_126354.1.1 m.33420 sp I23O1_RAT 40.051 392 223 6 9 391 16 404 2.97E-95 293 I23O1_RAT reviewed "Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)" Ido1 Ido Indo Rattus norvegicus (Rat) 407 immune system process [GO:0002376]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0002376; GO:0005829; GO:0016597; GO:0019441; GO:0019825; GO:0020037; GO:0033754; GO:0046872 0 0 0 PF01231; Q9NQT5 CHOYP_EXOS3.1.1 m.10596 sp EXOS3_HUMAN 47.036 253 108 3 10 237 24 275 2.97E-79 242 EXOS3_HUMAN reviewed Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10) EXOSC3 RRP40 CGI-102 Homo sapiens (Human) 275 "CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; isotype switching [GO:0045190]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [GO:0071049]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; regulation of mRNA stability [GO:0043488]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]" GO:0000175; GO:0000176; GO:0000177; GO:0000178; GO:0000467; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0034427; GO:0034475; GO:0035327; GO:0043488; GO:0043928; GO:0045006; GO:0045190; GO:0045830; GO:0071034; GO:0071035; GO:0071038; GO:0071049; GO:0071051 0 0 0 PF15985; Q9Z0T0 CHOYP_LOC101064328.2.3 m.57090 sp TPMT_RAT 33.484 221 140 5 27 240 19 239 2.97E-34 125 TPMT_RAT reviewed Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) Tpmt Rattus norvegicus (Rat) 240 nucleobase-containing compound metabolic process [GO:0006139]; response to organic cyclic compound [GO:0014070]; response to testosterone [GO:0033574] GO:0005737; GO:0006139; GO:0008119; GO:0014070; GO:0033574 0 0 0 PF05724; A2BE28 CHOYP_LOC100377803.1.1 m.13103 sp LAS1L_MOUSE 32.941 170 107 3 19 188 11 173 2.98E-22 104 LAS1L_MOUSE reviewed Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog) Las1l Mus musculus (Mouse) 776 chromatin organization [GO:0006325]; endonucleolytic cleavage involved in rRNA processing [GO:0000478]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0000478; GO:0005654; GO:0005730; GO:0005737; GO:0005815; GO:0006325; GO:0016020; GO:0030687; GO:0044822; GO:0071339 0 0 0 PF04031; A3RLT6 CHOYP_RSSA.4.10 m.29392 sp RSSA_PINFU 77.474 293 60 6 1 290 1 290 2.98E-146 416 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; E7F568 CHOYP_LOC100487213.2.4 m.53374 sp COBL_DANRE 26.957 230 141 6 68 293 59 265 2.98E-14 82 COBL_DANRE reviewed Protein cordon-bleu cobl Danio rerio (Zebrafish) (Brachydanio rerio) 1343 actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; auditory receptor cell stereocilium organization [GO:0060088]; cilium morphogenesis [GO:0060271]; heart jogging [GO:0003146]; heart looping [GO:0001947] GO:0001726; GO:0001947; GO:0003146; GO:0003785; GO:0005829; GO:0005856; GO:0005886; GO:0030041; GO:0051639; GO:0060088; GO:0060271 0 0 0 PF09469;PF02205; O45782 CHOYP_LOC100159260.1.1 m.36012 sp ARD17_CAEEL 26.756 299 201 10 15 305 6 294 2.98E-15 79.3 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; O70201 CHOYP_LOC100368744.1.1 m.7782 sp BIRC5_MOUSE 51.163 129 62 1 10 138 10 137 2.98E-42 139 BIRC5_MOUSE reviewed Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) (TIAP) Birc5 Api4 Iap4 Mus musculus (Mouse) 140 "cell division [GO:0051301]; chromosome segregation [GO:0007059]; cytokinesis [GO:0000910]; establishment of chromosome localization [GO:0051303]; G2/M transition of mitotic cell cycle [GO:0000086]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of mitotic cell cycle [GO:0045931]; protein complex localization [GO:0031503]; protein phosphorylation [GO:0006468]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of mitotic cell cycle [GO:0007346]; regulation of signal transduction [GO:0009966]; regulation of type B pancreatic cell proliferation [GO:0061469]; spindle checkpoint [GO:0031577]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0000226; GO:0000228; GO:0000775; GO:0000777; GO:0000910; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005814; GO:0005829; GO:0005876; GO:0005881; GO:0006351; GO:0006468; GO:0007059; GO:0007346; GO:0008017; GO:0008270; GO:0008536; GO:0009966; GO:0015631; GO:0019899; GO:0030496; GO:0031021; GO:0031503; GO:0031536; GO:0031577; GO:0032133; GO:0042802; GO:0042803; GO:0043027; GO:0043066; GO:0043154; GO:0043524; GO:0045892; GO:0045931; GO:0048037; GO:0051087; GO:0051301; GO:0051303; GO:0061178; GO:0061469; GO:0090307; GO:1990001 0 0 0 PF00653; O70277 CHOYP_NEMVEDRAFT_V1G160199.1.2 m.31962 sp TRIM3_RAT 25 216 149 6 298 508 537 744 2.98E-08 60.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_205965.14.43 m.37222 sp TRIM3_HUMAN 25.543 184 115 6 646 819 540 711 2.98E-06 54.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88456 CHOYP_CPNS1.1.1 m.5992 sp CPNS1_MOUSE 31.933 119 77 2 3 120 154 269 2.98E-14 69.7 CPNS1_MOUSE reviewed Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit) Capns1 Capn4 Mus musculus (Mouse) 269 0 GO:0004198; GO:0005509; GO:0005737; GO:0005829; GO:0005886; GO:0016020; GO:0070062 0 0 0 PF13833; O97758 CHOYP_ZO1.1.1 m.12165 sp ZO1_CANLF 69.6 125 34 2 96 220 1602 1722 2.98E-49 175 ZO1_CANLF reviewed Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Canis lupus familiaris (Dog) (Canis familiaris) 1769 bicellular tight junction assembly [GO:0070830]; cellular response to calcium ion [GO:0071277] GO:0005886; GO:0005911; GO:0005921; GO:0005923; GO:0009986; GO:0031410; GO:0070830; GO:0071277 0 0 0 PF00625;PF00595;PF07653;PF00791; P08537 CHOYP_TBB.5.7 m.60067 sp TBA_XENLA 96.45 169 6 0 1 169 1 169 2.98E-120 350 TBA_XENLA reviewed Tubulin alpha chain [Cleaved into: Detyrosinated tubulin alpha chain] tuba tuba1 Xenopus laevis (African clawed frog) 449 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P16157 CHOYP_TVAG_168010.12.45 m.33570 sp ANK1_HUMAN 30.76 816 481 12 6 791 25 786 2.98E-91 319 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18731 CHOYP_LOC101070806.1.1 m.57410 sp ZG62_XENLA 33.155 187 101 4 654 840 3 165 2.98E-21 95.5 ZG62_XENLA reviewed Gastrula zinc finger protein XlCGF62.1 (Fragment) 0 Xenopus laevis (African clawed frog) 169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; P22909 CHOYP_contig_022716 m.25960 sp ADA2A_RAT 27.143 140 89 5 251 381 303 438 2.98E-08 58.9 ADA2A_RAT reviewed Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Alpha-2D adrenergic receptor) (CA2-47) Adra2a Rattus norvegicus (Rat) 450 acute inflammatory response [GO:0002526]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; DNA replication [GO:0006260]; female pregnancy [GO:0007565]; glucose homeostasis [GO:0042593]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of uterine smooth muscle contraction [GO:0070473]; platelet activation [GO:0030168]; positive regulation of vasodilation [GO:0045909]; regulation of vasoconstriction [GO:0019229]; signal transduction [GO:0007165]; thermoception [GO:0050955] GO:0002526; GO:0004938; GO:0005737; GO:0005886; GO:0005887; GO:0006260; GO:0007165; GO:0007186; GO:0007565; GO:0019229; GO:0030168; GO:0042593; GO:0045202; GO:0045909; GO:0045955; GO:0050955; GO:0061179; GO:0070473; GO:0071880 0 0 0 PF00001; P26810 CHOYP_contig_017900 m.20936 sp POL_MLVF5 33.645 214 131 5 5 214 883 1089 2.98E-27 112 POL_MLVF5 reviewed Pol polyprotein [Cleaved into: Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Friend murine leukemia virus (isolate 57) (FrMLV) 1204 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003676; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00075;PF00665;PF00077;PF00078; P28648 CHOYP_BRAFLDRAFT_124708.2.2 m.36045 sp CD63_RAT 38.333 240 144 3 2 241 3 238 2.98E-53 174 CD63_RAT reviewed CD63 antigen (Mast cell antigen AD1) (CD antigen CD63) Cd63 Rattus norvegicus (Rat) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigment granule maturation [GO:0048757]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endocytosis [GO:0045807]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005737; GO:0005764; GO:0005765; GO:0005886; GO:0005887; GO:0007160; GO:0007166; GO:0010633; GO:0012505; GO:0015031; GO:0016021; GO:0016477; GO:0030658; GO:0030855; GO:0031226; GO:0031902; GO:0032403; GO:0035646; GO:0042470; GO:0043234; GO:0045785; GO:0045807; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2001046 0 0 0 PF00335; P38542 CHOYP_RAN.1.3 m.3467 sp RAN_BRUMA 92.121 165 13 0 2 166 4 168 2.98E-113 323 RAN_BRUMA reviewed GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Bm1_44725 Brugia malayi (Filarial nematode worm) 215 intracellular protein transport [GO:0006886]; nucleocytoplasmic transport [GO:0006913]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0006886; GO:0006913; GO:0007264 0 0 0 PF00071; P82596 CHOYP_LOC100183059.2.4 m.15412 sp PLC_HALLA 30.464 151 91 4 241 391 2 138 2.98E-17 81.6 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q09575 CHOYP_LOC100372741.2.3 m.34229 sp YRD6_CAEEL 29.87 308 194 9 292 596 717 1005 2.98E-30 131 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q15024 CHOYP_EXOS7.1.1 m.3323 sp EXOS7_HUMAN 62.414 290 108 1 35 323 1 290 2.98E-128 370 EXOS7_HUMAN reviewed Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8) EXOSC7 KIAA0116 RRP42 Homo sapiens (Human) 291 "exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; regulation of mRNA stability [GO:0043488]; RNA catabolic process [GO:0006401]; rRNA processing [GO:0006364]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" GO:0000175; GO:0000176; GO:0000177; GO:0000178; GO:0000467; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006364; GO:0006401; GO:0017091; GO:0034427; GO:0034473; GO:0034475; GO:0034476; GO:0043488; GO:0043928; GO:0071028; GO:0071035; GO:0071038; GO:0071042 0 0 0 PF01138;PF03725; Q29496 CHOYP_CP3AL.1.1 m.47222 sp CP3AO_SHEEP 38.983 177 104 4 1 176 1 174 2.98E-34 129 CP3AO_SHEEP reviewed Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) 503 0 GO:0004497; GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q2KHZ4 CHOYP_LOC100704237.2.2 m.20804 sp MIA40_BOVIN 36.62 142 83 3 1 141 1 136 2.98E-25 97.1 MIA40_BOVIN reviewed Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) CHCHD4 MIA40 Bos taurus (Bovine) 137 'de novo' posttranslational protein folding [GO:0051084]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation by protein folding [GO:0022417] GO:0005758; GO:0015035; GO:0022417; GO:0045041; GO:0051084 0 0 0 PF06747; Q2QAV0 CHOYP_EIN_093700.1.1 m.45857 sp TIO_ARATH 30.256 195 117 7 72 257 18 202 2.98E-16 83.6 TIO_ARATH reviewed Serine/threonine-protein kinase TIO (EC 2.7.11.1) (Fused homolog) (AtFUSED) (Protein TWO-IN-ONE) (AtTIO) TIO FU At1g50240 At1g50230 F14I3.15 Arabidopsis thaliana (Mouse-ear cress) 1322 cytokinesis by cell plate formation [GO:0000911]; embryo sac cellularization [GO:0009558] GO:0000911; GO:0004674; GO:0005524; GO:0005856; GO:0009524; GO:0009558 0 0 0 PF00069; Q3SZ45 CHOYP_LOC100562697.1.1 m.27375 sp SDF2_BOVIN 63.043 184 68 0 31 214 17 200 2.98E-81 244 SDF2_BOVIN reviewed Stromal cell-derived factor 2 (SDF-2) SDF2 Bos taurus (Bovine) 211 cell wall mannoprotein biosynthetic process [GO:0000032]; chain elongation of O-linked mannose residue [GO:0044845]; multicellular organism development [GO:0007275]; protein O-linked mannosylation [GO:0035269]; regulation of endoplasmic reticulum unfolded protein response [GO:1900101] GO:0000032; GO:0005576; GO:0007275; GO:0031502; GO:0035269; GO:0044845; GO:1900101 0 0 0 PF02815; Q7Z2W7 CHOYP_TRPM4C.2.3 m.59452 sp TRPM8_HUMAN 23.252 658 383 20 397 1000 461 1050 2.98E-38 159 TRPM8_HUMAN reviewed Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) 1104 calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955] GO:0005262; GO:0005789; GO:0005886; GO:0006874; GO:0009409; GO:0009897; GO:0016021; GO:0016048; GO:0045121; GO:0050955; GO:0051289; GO:0070207; GO:0070588 0 0 0 PF00520; Q7ZV00 CHOYP_OTU6B.1.2 m.31547 sp OTU6B_DANRE 45.675 289 149 3 4 291 5 286 2.98E-82 253 OTU6B_DANRE reviewed OTU domain-containing protein 6B (EC 3.4.19.12) otud6b zgc:56305 Danio rerio (Zebrafish) (Brachydanio rerio) 293 0 GO:0036459 0 0 0 PF02338; Q8IRC7 CHOYP_AWH.2.2 m.14555 sp AWH_DROME 58.621 203 79 1 48 245 4 206 2.98E-83 254 AWH_DROME reviewed LIM/homeobox protein Awh (Protein arrowhead) Awh CG1072 Drosophila melanogaster (Fruit fly) 275 "compound eye development [GO:0048749]; imaginal disc development [GO:0007444]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0007444; GO:0008270; GO:0010468; GO:0048749 0 0 0 PF00046;PF00412; Q8VI56 CHOYP_LOC578656.13.15 m.59800 sp LRP4_MOUSE 27.199 864 573 26 108 944 514 1348 2.98E-85 309 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q91312 CHOYP_SMP_164730.1.1 m.50232 sp CRYAB_LITCT 36.667 120 72 3 9 126 48 165 2.98E-18 79 CRYAB_LITCT reviewed Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 173 0 GO:0005212; GO:0042803; GO:0046872 0 0 0 PF00525;PF00011; Q96RW7 CHOYP_LOC101172646.1.2 m.29245 sp HMCN1_HUMAN 44.776 67 32 2 95 159 4622 4685 2.98E-13 70.1 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99M80 CHOYP_PTPRE.19.19 m.63504 sp PTPRT_MOUSE 42.969 256 143 2 336 589 902 1156 2.98E-56 209 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99PP7 CHOYP_TRI33.2.8 m.14668 sp TRI33_MOUSE 34.925 398 234 8 14 408 138 513 2.98E-61 230 TRI33_MOUSE reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Trim33 Kiaa1113 Mus musculus (Mouse) 1142 "negative regulation of BMP signaling pathway [GO:0030514]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q9CQL5 CHOYP_LOC100908121.1.1 m.11372 sp RM18_MOUSE 39.855 138 83 0 46 183 37 174 2.98E-30 112 RM18_MOUSE reviewed "39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18)" Mrpl18 Mus musculus (Mouse) 180 rRNA import into mitochondrion [GO:0035928]; translation [GO:0006412] GO:0003735; GO:0005615; GO:0005739; GO:0005840; GO:0006412; GO:0008097; GO:0035928 0 0 0 PF00861; Q9CZJ2 CHOYP_HS12A.9.33 m.37610 sp HS12B_MOUSE 36.551 632 332 15 20 591 61 683 2.98E-124 384 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9FMB4 CHOYP_MTR_7G016900.1.1 m.39323 sp AUG5_ARATH 23.251 529 310 16 11 454 12 529 2.98E-16 86.7 AUG5_ARATH reviewed AUGMIN subunit 5 AUG5 At5g38880 K15E6.9 Arabidopsis thaliana (Mouse-ear cress) 796 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0005876; GO:0007067; GO:0009524; GO:0051011; GO:0051225; GO:0051301; GO:0070652 0 0 0 PF14817; Q9H0U3 CHOYP_TUSC3.1.1 m.40571 sp MAGT1_HUMAN 61.875 320 122 0 23 342 14 333 2.98E-153 436 MAGT1_HUMAN reviewed Magnesium transporter protein 1 (MagT1) (Implantation-associated protein) (IAP) MAGT1 IAG2 PSEC0084 UNQ628/PRO1244 Homo sapiens (Human) 335 cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085] GO:0005886; GO:0005887; GO:0006487; GO:0008250; GO:0015095; GO:0015693; GO:0016020; GO:0018279; GO:0050890; GO:0055085 0 0 0 PF04756; Q9H8W5 CHOYP_BRAFLDRAFT_88224.11.11 m.61931 sp TRI45_HUMAN 23.939 330 200 11 17 304 27 347 2.98E-10 66.6 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9I9M5 CHOYP_LOC101165060.1.1 m.55042 sp FZD1_XENLA 59.868 152 54 3 22 168 38 187 2.98E-57 194 FZD1_XENLA reviewed Frizzled-1 (Fz-1) (Xfz1) fzd1 fz1 Xenopus laevis (African clawed frog) 559 multicellular organism development [GO:0007275] GO:0004930; GO:0005886; GO:0007275; GO:0016021; GO:0042813 0 0 0 PF01534;PF01392; Q9SZJ2 CHOYP_LOC100367312.13.13 m.64892 sp GRDP2_ARATH 40.071 282 160 4 55 328 15 295 2.98E-56 210 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; Q9VIU7 CHOYP_BRAFLDRAFT_276832.1.2 m.7666 sp DPM1_DROME 28.676 136 76 6 257 375 7 138 2.98E-08 58.2 DPM1_DROME reviewed Probable dolichol-phosphate mannosyltransferase (DPM synthase) (Dolichol-phosphate mannose synthase) (EC 2.4.1.83) (Dolichyl-phosphate beta-D-mannosyltransferase) (Mannose-P-dolichol synthase) (MPD synthase) CG10166 Drosophila melanogaster (Fruit fly) 241 dolichol metabolic process [GO:0019348]; GPI anchor biosynthetic process [GO:0006506]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein O-linked mannosylation [GO:0035269] GO:0004169; GO:0004582; GO:0005789; GO:0006486; GO:0006487; GO:0006506; GO:0019348; GO:0035269 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535; Q9VS34 CHOYP_LOC100203649.1.1 m.23122 sp RL18_DROME 67.914 187 60 0 8 194 1 187 2.98E-88 260 RL18_DROME reviewed 60S ribosomal protein L18 RpL18 CG8615 Drosophila melanogaster (Fruit fly) 188 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; translation [GO:0006412] GO:0000022; GO:0003723; GO:0003735; GO:0005840; GO:0006412; GO:0007052; GO:0022625 0 0 0 PF17135; Q9XWB9 CHOYP_LOC101236379.1.2 m.22738 sp BAT36_CAEEL 31.683 101 67 2 55 154 157 256 2.98E-07 54.3 BAT36_CAEEL reviewed BTB and MATH domain-containing protein 36 bath-36 Y75B12B.4 Caenorhabditis elegans 320 0 0 0 0 0 PF00651;PF00917; A2AX52 CHOYP_LOC100486063.6.9 m.44250 sp CO6A4_MOUSE 24.98 1245 803 38 921 2135 34 1177 2.99E-90 332 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A6X391 CHOYP_NEMVEDRAFT_V1G197278.1.1 m.45568 sp DEACT_OCHA4 35.989 364 211 10 39 399 26 370 2.99E-53 186 DEACT_OCHA4 reviewed Deacetylase Oant_2987 (EC 3.1.1.-) Oant_2987 Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168) 402 0 GO:0016810; GO:0046872; GO:0052689 0 0 0 PF01979; D3YXG0 CHOYP_LOC100707926.3.4 m.44638 sp HMCN1_MOUSE 23.423 333 192 15 116 401 2635 2951 2.99E-10 66.2 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O08623 CHOYP_LOC100376279.1.1 m.11154 sp SQSTM_RAT 55.556 45 20 0 66 110 387 431 2.99E-09 56.6 SQSTM_RAT reviewed Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62) Sqstm1 Zip Rattus norvegicus (Rat) 439 apoptotic process [GO:0006915]; autophagy [GO:0006914]; cell differentiation [GO:0030154]; immune system process [GO:0002376]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein phosphorylation [GO:0001934]; protein heterooligomerization [GO:0051291]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of protein complex stability [GO:0061635]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000407; GO:0000932; GO:0001934; GO:0002376; GO:0005080; GO:0005770; GO:0005776; GO:0005783; GO:0006511; GO:0006914; GO:0006915; GO:0008270; GO:0016235; GO:0016236; GO:0016239; GO:0016605; GO:0030154; GO:0031410; GO:0042169; GO:0042803; GO:0043122; GO:0043130; GO:0044130; GO:0044753; GO:0044754; GO:0051291; GO:0061635; GO:0070062; GO:0097225; GO:0098779 0 0 0 PF00564;PF00569; O45782 CHOYP_LOC100496973.7.8 m.61763 sp ARD17_CAEEL 32.923 325 192 7 1 313 1 311 2.99E-48 181 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; O70277 CHOYP_contig_044898 m.52088 sp TRIM3_RAT 24.615 130 91 3 229 351 614 743 2.99E-06 53.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75592 CHOYP_MYCBP2.1.1 m.27071 sp MYCB2_HUMAN 45.299 234 115 3 33 259 156 383 2.99E-55 194 MYCB2_HUMAN reviewed E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) 4640 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016020; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF00630;PF08005;PF00415;PF08239;PF13639; P45447 CHOYP_LOC100377194.2.2 m.16185 sp E78C_DROME 91.667 84 7 0 108 191 360 443 2.99E-51 182 E78C_DROME reviewed Ecdysone-induced protein 78C (DR-78) (Nuclear receptor subfamily 1 group E member 1) Eip78C NR1E1 CG18023 Drosophila melanogaster (Fruit fly) 862 "negative regulation of transcription, DNA-templated [GO:0045892]; regulation of glucose metabolic process [GO:0010906]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0010906; GO:0043565; GO:0045892 0 0 0 PF00104;PF00105; P49230 CHOYP_PROF.1.2 m.38478 sp PROF_ENTHI 34 100 65 1 24 122 22 121 2.99E-11 59.7 PROF_ENTHI reviewed Profilin 0 Entamoeba histolytica 130 0 GO:0005737; GO:0005856 0 0 0 PF00235; P49652 CHOYP_TVAG_216960.1.4 m.14961 sp P2RY1_MELGA 29.452 146 91 5 27 166 43 182 2.99E-07 55.1 P2RY1_MELGA reviewed P2Y purinoceptor 1 (P2Y1) (6H1 orphan receptor) (ATP receptor) (Purinergic receptor) P2RY1 Meleagris gallopavo (Common turkey) 362 cellular response to organic cyclic compound [GO:0071407]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; platelet activation [GO:0030168]; positive regulation of ion transport [GO:0043270]; relaxation of muscle [GO:0090075] GO:0005886; GO:0007200; GO:0009986; GO:0016021; GO:0030168; GO:0043270; GO:0045028; GO:0071407; GO:0090075 0 0 0 PF00001; P56407 CHOYP_LOC580883.1.1 m.1785 sp HM09_CAEEL 76.923 65 15 0 143 207 66 130 2.99E-27 107 HM09_CAEEL reviewed Homeobox protein ceh-9 ceh-9 Y65B4BR.9 Caenorhabditis elegans 147 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; P62972 CHOYP_LOC100190730.1.2 m.8882 sp UBIQP_XENLA 100 123 0 0 1 123 16 138 2.99E-84 246 UBIQP_XENLA reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Xenopus laevis (African clawed frog) 167 0 GO:0005634; GO:0005737 0 0 0 PF00240; Q25490 CHOYP_LS14A.3.3 m.12694 sp APLP_MANSE 24.409 254 157 9 28 260 643 882 2.99E-08 61.6 APLP_MANSE reviewed Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 3305 Wnt signaling pathway [GO:0016055] GO:0005319; GO:0005576; GO:0008289; GO:0016055 0 0 0 PF06448;PF09172;PF01347;PF00094; Q27421 CHOYP_GOGB1.2.2 m.66418 sp OSP_DROME 55.422 166 62 3 5 160 39 202 2.99E-51 204 OSP_DROME reviewed Protein outspread osp CG3479 Drosophila melanogaster (Fruit fly) 1566 0 0 0 0 0 PF00169; Q2TBL4 CHOYP_RPC3.2.3 m.7940 sp RPC3_BOVIN 43.883 515 238 9 5 474 1 509 2.99E-141 419 RPC3_BOVIN reviewed DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) POLR3C Bos taurus (Bovine) 533 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003677; GO:0003899; GO:0005666; GO:0006383; GO:0032728; GO:0045087; GO:0045089; GO:0051607 0 0 0 PF08221;PF05645; Q3SWZ4 CHOYP_EXOS9.1.1 m.12468 sp EXOS9_BOVIN 59.829 351 138 1 1 351 1 348 2.99E-148 431 EXOS9_BOVIN reviewed Exosome complex component RRP45 (Exosome component 9) EXOSC9 Bos taurus (Bovine) 440 "exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" GO:0000176; GO:0000177; GO:0000178; GO:0000228; GO:0000467; GO:0005654; GO:0005730; GO:0017091; GO:0034427; GO:0034473; GO:0034475; GO:0034476; GO:0043928; GO:0071028; GO:0071035; GO:0071038; GO:0071042 0 0 cd11368; PF01138;PF03725; Q4R5M4 CHOYP_YIPF5.2.2 m.43959 sp YIPF5_MACFA 56.031 257 109 2 38 290 1 257 2.99E-93 279 YIPF5_MACFA reviewed Protein YIPF5 (YIP1 family member 5) YIPF5 QccE-13521 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 257 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0015031; GO:0016021; GO:0016192; GO:0030134; GO:0032580 0 0 0 PF04893; Q505J9 CHOYP_ATAD1.1.1 m.49189 sp ATAD1_RAT 51.989 352 162 3 21 371 2 347 2.99E-129 378 ATAD1_RAT reviewed ATPase family AAA domain-containing protein 1 (EC 3.6.1.3) (Thorase) Atad1 Npg6 Rattus norvegicus (Rat) 361 "cytoplasmic microtubule organization [GO:0031122]; learning [GO:0007612]; memory [GO:0007613]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; positive regulation of receptor internalization [GO:0002092]" GO:0002092; GO:0005524; GO:0005634; GO:0005777; GO:0007612; GO:0007613; GO:0008568; GO:0016887; GO:0030054; GO:0031122; GO:0045211; GO:0051967 0 0 0 PF00004; Q58DN7 CHOYP_ACSF3.1.1 m.14825 sp ACSF3_BOVIN 44.139 546 279 9 62 595 43 574 2.99E-154 458 ACSF3_BOVIN reviewed "Acyl-CoA synthetase family member 3, mitochondrial (EC 6.2.1.-)" ACSF3 Bos taurus (Bovine) 586 fatty acid biosynthetic process [GO:0006633]; malonate catabolic process [GO:0090410] GO:0005524; GO:0005739; GO:0006633; GO:0090409; GO:0090410 0 0 0 PF00501;PF13193; Q5JXM2 CHOYP_LOC100373794.5.5 m.63163 sp MET24_HUMAN 25.63 238 144 8 335 542 131 365 2.99E-11 68.6 MET24_HUMAN reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) METTL24 C6orf186 Homo sapiens (Human) 366 0 GO:0005576; GO:0008168 0 0 0 PF13383; Q6P0F9 CHOYP_LOC100376695.2.2 m.36384 sp INS1A_DANRE 39.529 425 185 18 1 400 1 378 2.99E-70 229 INS1A_DANRE reviewed Insulinoma-associated protein 1a (Insulinoma-associated 1-like protein a) (Zinc finger protein IA-1a) insm1a Danio rerio (Zebrafish) (Brachydanio rerio) 383 "cell dedifferentiation [GO:0043697]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pancreatic A cell differentiation [GO:0003310]; regulation of cell cycle process [GO:0010564]; retinal cone cell differentiation [GO:0042670]; retinal rod cell differentiation [GO:0060221]; sensory epithelium regeneration [GO:0070654]; transcription, DNA-templated [GO:0006351]; transdifferentiation [GO:0060290]; type B pancreatic cell differentiation [GO:0003309]" GO:0000122; GO:0001047; GO:0003309; GO:0003310; GO:0003700; GO:0005634; GO:0006351; GO:0010564; GO:0017053; GO:0031490; GO:0042670; GO:0043565; GO:0043697; GO:0045892; GO:0046872; GO:0060221; GO:0060290; GO:0070654 0 0 0 0 Q6R7G0 CHOYP_Y068.2.6 m.10224 sp Y068_OSHVF 23.015 617 397 13 418 966 25 631 2.99E-40 163 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6XIM8 CHOYP_RS15A.8.11 m.31042 sp RS15A_DROYA 85.217 115 17 0 1 115 1 115 2.99E-72 214 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q7TT16 CHOYP_LOC100368588.1.1 m.64173 sp IPMK_MOUSE 33.687 377 196 6 49 373 22 396 2.99E-66 218 IPMK_MOUSE reviewed "Inositol polyphosphate multikinase (EC 2.7.1.151) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)" Ipmk Impk Mus musculus (Mouse) 396 inositol phosphate biosynthetic process [GO:0032958]; neural tube formation [GO:0001841] GO:0000823; GO:0000824; GO:0001841; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0008440; GO:0032958 0 0 0 PF03770; Q80SX5 CHOYP_LOC100902588.2.2 m.55627 sp OTOP2_MOUSE 23.518 523 289 17 348 804 83 560 2.99E-25 114 OTOP2_MOUSE reviewed Otopetrin-2 Otop2 Mus musculus (Mouse) 563 0 GO:0016021 0 0 0 PF03189; Q811F1 CHOYP_ZN521.3.3 m.15324 sp ZBT41_MOUSE 24.074 270 168 9 527 778 347 597 2.99E-07 58.5 ZBT41_MOUSE reviewed Zinc finger and BTB domain-containing protein 41 Zbtb41 Mus musculus (Mouse) 908 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF13912; Q8K480 CHOYP_LOC100879487.2.3 m.32793 sp MFRP_MOUSE 38.462 104 56 3 171 267 265 367 2.99E-11 66.6 MFRP_MOUSE reviewed Membrane frizzled-related protein (Membrane-type frizzled-related protein) Mfrp Mus musculus (Mouse) 584 eye photoreceptor cell development [GO:0042462]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] GO:0007601; GO:0016021; GO:0016324; GO:0042462; GO:0060041 0 0 0 PF00431;PF01392;PF00057; Q8R1F0 CHOYP_LOC100378819.1.1 m.20252 sp L10K_MOUSE 40 90 51 1 23 112 1 87 2.99E-13 63.5 L10K_MOUSE reviewed Leydig cell tumor 10 kDa protein homolog D8Ertd738e Mus musculus (Mouse) 94 0 0 0 0 0 PF09495; Q924X7 CHOYP_STK33.1.1 m.8044 sp STK33_MOUSE 54.754 305 133 3 12 312 96 399 2.99E-114 346 STK33_MOUSE reviewed Serine/threonine-protein kinase 33 (EC 2.7.11.1) Stk33 Mus musculus (Mouse) 491 protein autophosphorylation [GO:0046777] GO:0004674; GO:0005524; GO:0046777; GO:0048471 0 0 0 PF00069; Q96MM6 CHOYP_BRAFLDRAFT_208293.6.20 m.36168 sp HS12B_HUMAN 34.913 633 345 13 12 584 61 686 2.99E-114 358 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_242762.5.8 m.22699 sp HS12B_HUMAN 28.512 484 280 15 8 436 61 533 2.99E-49 181 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MM6 CHOYP_HS12A.1.33 m.779 sp HS12B_HUMAN 23.591 479 281 19 3 407 61 528 2.99E-14 79 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96XY5 CHOYP_LOC100928016.5.6 m.50449 sp Y2383_SULTO 45.185 135 69 1 192 326 1 130 2.99E-34 129 Y2383_SULTO reviewed Uncharacterized protein STK_23830 STK_23830 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 182 0 0 0 0 0 PF01661; Q99N85 CHOYP_DSEC_GM26335.1.1 m.26661 sp RT18A_MOUSE 40.777 103 52 3 29 129 39 134 2.99E-19 82.4 RT18A_MOUSE reviewed "28S ribosomal protein S18a, mitochondrial (MRP-S18-a) (Mrps18a) (S18mt-a) (28S ribosomal protein S18-3, mitochondrial) (MRP-S18-3)" Mrps18a Mus musculus (Mouse) 196 mitochondrial translation [GO:0032543] GO:0003735; GO:0005739; GO:0005763; GO:0022627; GO:0032543 0 0 0 PF01084; Q9VCA8 CHOYP_LOC100641729.9.10 m.53920 sp ANKHM_DROME 47.2 125 62 3 11 131 620 744 2.99E-24 100 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; D2GXS7 CHOYP_LOC100373444.16.79 m.20625 sp TRIM2_AILME 24.434 221 147 5 322 534 536 744 3.00E-08 60.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_BRAFLDRAFT_85664.4.10 m.27079 sp HMCN1_MOUSE 38.01 392 224 10 277 654 4483 4869 3.00E-68 251 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; F6ZQ54 CHOYP_LOC101077612.1.1 m.24160 sp TRI13_XENTR 22.051 195 132 5 4 194 78 256 3.00E-06 50.8 TRI13_XENTR reviewed Tripartite motif containing 13 trim13 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 408 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; O14832 CHOYP_LOC100690874.2.2 m.63411 sp PAHX_HUMAN 60.486 329 122 3 2 326 7 331 3.00E-152 433 PAHX_HUMAN reviewed "Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)" PHYH PAHX Homo sapiens (Human) 338 fatty acid alpha-oxidation [GO:0001561]; isoprenoid metabolic process [GO:0006720]; methyl-branched fatty acid metabolic process [GO:0097089] GO:0001561; GO:0005739; GO:0005777; GO:0005782; GO:0006720; GO:0031418; GO:0046872; GO:0048037; GO:0048244; GO:0097089 PATHWAY: Lipid metabolism; fatty acid metabolism. 0 0 PF05721; O73881 CHOYP_U184.1.1 m.6612 sp CI016_TAKRU 40.909 66 33 1 46 111 12 71 3.00E-08 51.2 CI016_TAKRU reviewed UPF0184 protein C9orf16 homolog EST00098 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 108 0 0 0 0 0 PF03670; O96064 CHOYP_MYSP.9.9 m.49632 sp MYSP_MYTGA 55.128 156 45 1 1 156 28 158 3.00E-45 160 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P05450 CHOYP_contig_039058 m.44237 sp YAT7_RHOBL 26.263 99 70 1 13 108 8 106 3.00E-07 48.1 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P35953 CHOYP_PHUM_PHUM066670.3.3 m.58849 sp VLDLR_RABIT 40.767 287 150 7 28 297 33 316 3.00E-49 181 VLDLR_RABIT reviewed Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) VLDLR Oryctolagus cuniculus (Rabbit) 873 cholesterol metabolic process [GO:0008203]; dendrite morphogenesis [GO:0048813]; lipid transport [GO:0006869]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dendrite development [GO:1900006]; positive regulation of protein kinase activity [GO:0045860]; ventral spinal cord development [GO:0021517]; very-low-density lipoprotein particle clearance [GO:0034447] GO:0000122; GO:0001948; GO:0005509; GO:0005905; GO:0006869; GO:0008203; GO:0016021; GO:0021517; GO:0030229; GO:0034189; GO:0034361; GO:0034437; GO:0034447; GO:0038025; GO:0043235; GO:0045860; GO:0048813; GO:1900006 0 0 0 PF07645;PF00057;PF00058; P36404 CHOYP_LOC100370080.1.1 m.14971 sp ARL2_HUMAN 86.413 184 25 0 1 184 1 184 3.00E-117 332 ARL2_HUMAN reviewed ADP-ribosylation factor-like protein 2 ARL2 Homo sapiens (Human) 184 bicellular tight junction assembly [GO:0070830]; cell cycle [GO:0007049]; centrosome organization [GO:0051297]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of GTPase activity [GO:0034260]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of microtubule polymerization [GO:0031116]; regulation of insulin secretion [GO:0050796]; regulation of microtubule polymerization [GO:0031113]; small GTPase mediated signal transduction [GO:0007264]; tubulin complex assembly [GO:0007021] GO:0003924; GO:0005095; GO:0005525; GO:0005634; GO:0005758; GO:0005759; GO:0005813; GO:0005829; GO:0007021; GO:0007049; GO:0007264; GO:0010811; GO:0016328; GO:0031113; GO:0031116; GO:0034260; GO:0050796; GO:0051297; GO:0051457; GO:0070062; GO:0070830 0 0 0 PF00025; P42232 CHOYP_STAT1.1.2 m.1003 sp STA5B_MOUSE 22.063 698 418 26 41 681 29 657 3.00E-22 107 STA5B_MOUSE reviewed Signal transducer and activator of transcription 5B Stat5b Mus musculus (Mouse) 786 2-oxoglutarate metabolic process [GO:0006103]; acute-phase response [GO:0006953]; allantoin metabolic process [GO:0000255]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hormone stimulus [GO:0032870]; citrate metabolic process [GO:0006101]; creatine metabolic process [GO:0006600]; creatinine metabolic process [GO:0046449]; cytokine-mediated signaling pathway [GO:0019221]; development of secondary female sexual characteristics [GO:0046543]; development of secondary male sexual characteristics [GO:0046544]; fatty acid metabolic process [GO:0006631]; female pregnancy [GO:0007565]; isoleucine metabolic process [GO:0006549]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; lactation [GO:0007595]; lipid storage [GO:0019915]; liver development [GO:0001889]; luteinization [GO:0001553]; mast cell migration [GO:0097531]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; oxaloacetate metabolic process [GO:0006107]; Peyer's patch development [GO:0048541]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cellular component movement [GO:0051272]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 biosynthetic process [GO:0045086]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; progesterone metabolic process [GO:0042448]; prolactin signaling pathway [GO:0038161]; regulation of cell adhesion [GO:0030155]; regulation of epithelial cell differentiation [GO:0030856]; regulation of multicellular organism growth [GO:0040014]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to lipopolysaccharide [GO:0032496]; sex differentiation [GO:0007548]; succinate metabolic process [GO:0006105]; taurine metabolic process [GO:0019530]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; valine metabolic process [GO:0006573] GO:0000255; GO:0000979; GO:0001077; GO:0001553; GO:0001666; GO:0001779; GO:0001889; GO:0003677; GO:0003682; GO:0004871; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006101; GO:0006103; GO:0006105; GO:0006107; GO:0006357; GO:0006549; GO:0006573; GO:0006600; GO:0006631; GO:0006953; GO:0007259; GO:0007548; GO:0007565; GO:0007595; GO:0008284; GO:0019218; GO:0019221; GO:0019530; GO:0019903; GO:0019915; GO:0030155; GO:0030856; GO:0032355; GO:0032496; GO:0032819; GO:0032825; GO:0032870; GO:0033077; GO:0035259; GO:0038161; GO:0040014; GO:0040018; GO:0042104; GO:0042448; GO:0043029; GO:0043066; GO:0045086; GO:0045471; GO:0045579; GO:0045588; GO:0045621; GO:0045647; GO:0045648; GO:0045931; GO:0045944; GO:0045954; GO:0046449; GO:0046543; GO:0046544; GO:0046983; GO:0048541; GO:0048661; GO:0050729; GO:0051272; GO:0060397; GO:0070669; GO:0070670; GO:0070672; GO:0071363; GO:0071364; GO:0097531 0 0 0 PF00017;PF01017;PF02864;PF02865; P42577 CHOYP_FRIS.9.11 m.53960 sp FRIS_LYMST 83.626 171 28 0 1 171 1 171 3.00E-105 301 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P49013 CHOYP_TRIADDRAFT_26633.1.6 m.15519 sp FBP3_STRPU 47.345 226 105 4 1 225 183 395 3.00E-51 186 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P51810 CHOYP_LOC100679934.1.1 m.24956 sp GP143_HUMAN 27.642 246 163 6 76 309 70 312 3.00E-26 111 GP143_HUMAN reviewed G-protein coupled receptor 143 (Ocular albinism type 1 protein) GPR143 OA1 Homo sapiens (Human) 404 calcium-mediated signaling using intracellular calcium source [GO:0035584]; eye pigment biosynthetic process [GO:0006726]; G-protein coupled receptor signaling pathway [GO:0007186]; melanosome localization [GO:0032400]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; phosphatidylinositol-mediated signaling [GO:0048015]; regulation of calcium-mediated signaling [GO:0050848]; regulation of melanosome organization [GO:1903056]; regulation of melanosome transport [GO:1902908]; signal transduction [GO:0007165]; visual perception [GO:0007601] GO:0004930; GO:0005737; GO:0005765; GO:0005794; GO:0005886; GO:0006726; GO:0007165; GO:0007186; GO:0007601; GO:0016020; GO:0016021; GO:0016324; GO:0032400; GO:0032402; GO:0032438; GO:0033162; GO:0035240; GO:0035584; GO:0035643; GO:0042470; GO:0048015; GO:0050848; GO:0072544; GO:0072545; GO:1902908; GO:1903056 0 0 0 PF02101; P56962 CHOYP_STX17.1.1 m.116 sp STX17_HUMAN 38.361 305 160 6 32 318 6 300 3.00E-54 182 STX17_HUMAN reviewed Syntaxin-17 STX17 Homo sapiens (Human) 302 autophagosome maturation [GO:0097352]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to pre-autophagosomal structure [GO:0034497]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000149; GO:0000421; GO:0005484; GO:0005739; GO:0005789; GO:0005793; GO:0005829; GO:0006886; GO:0006888; GO:0006906; GO:0007030; GO:0012507; GO:0016021; GO:0019903; GO:0030134; GO:0030868; GO:0031201; GO:0033116; GO:0034497; GO:0044233; GO:0048278; GO:0097111; GO:0097352 0 0 0 0 Q01484 CHOYP_TVAG_470020.3.8 m.24384 sp ANK2_HUMAN 32.867 286 155 1 2 250 54 339 3.00E-46 168 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q0P4C4 CHOYP_LOC101482309.1.1 m.35844 sp DCAKD_DANRE 50 230 114 1 17 246 1 229 3.00E-75 230 DCAKD_DANRE reviewed Dephospho-CoA kinase domain-containing protein dcakd zgc:153150 Danio rerio (Zebrafish) (Brachydanio rerio) 229 coenzyme A biosynthetic process [GO:0015937] GO:0004140; GO:0005524; GO:0015937 0 0 cd02022; PF01121; Q2EMV9 CHOYP_LOC100367414.6.7 m.61300 sp PAR14_MOUSE 21.014 414 292 11 644 1036 460 859 3.00E-09 65.1 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q562C7 CHOYP_K0020.1.1 m.1673 sp PUM3_RAT 45.577 520 279 3 969 1484 128 647 3.00E-155 489 PUM3_RAT reviewed Pumilio homolog 3 Pum3 Rattus norvegicus (Rat) 647 regulation of protein ADP-ribosylation [GO:0010835]; regulation of translation [GO:0006417] GO:0003677; GO:0003729; GO:0005654; GO:0005694; GO:0005730; GO:0006417; GO:0010835 0 0 0 PF08144; Q5GH73 CHOYP_BRAFLDRAFT_110042.1.2 m.4116 sp XKR6_HUMAN 25.622 402 246 7 83 442 114 504 3.00E-27 118 XKR6_HUMAN reviewed XK-related protein 6 XKR6 C8orf21 C8orf5 C8orf7 XRG6 Homo sapiens (Human) 641 0 GO:0016020; GO:0016021 0 0 0 PF09815; Q5I0S6 CHOYP_ATG3.1.1 m.25570 sp ATG3_XENTR 66.975 324 93 5 1 322 1 312 3.00E-151 429 ATG3_XENTR reviewed Ubiquitin-like-conjugating enzyme ATG3 (EC 6.3.2.-) (Autophagy-related protein 3) (APG3-like) atg3 apg3l TEgg015l06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 312 autophagosome assembly [GO:0000045]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitophagy [GO:0000422]; nucleophagy [GO:0044804]; protein transport [GO:0015031] GO:0000045; GO:0000153; GO:0000422; GO:0005829; GO:0015031; GO:0016874; GO:0019776; GO:0019777; GO:0043653; GO:0044804 0 0 0 PF03987;PF10381;PF03986; Q5ZLF0 CHOYP_F10A1.1.4 m.11460 sp F10A1_CHICK 57.358 265 109 3 20 284 4 264 3.00E-96 293 F10A1_CHICK reviewed Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) ST13 FAM10A1 RCJMB04_6h13 Gallus gallus (Chicken) 361 0 GO:0005737 0 0 0 PF13181; Q5ZMD4 CHOYP_BRAFLDRAFT_109857.12.15 m.50263 sp TRI59_CHICK 32.653 98 60 3 58 155 8 99 3.00E-07 54.7 TRI59_CHICK reviewed Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) 408 cilium assembly [GO:0042384] GO:0005783; GO:0005789; GO:0005813; GO:0005929; GO:0008270; GO:0016021; GO:0030992; GO:0042384 0 0 0 PF00643;PF13445; Q6UVM3 CHOYP_ISCW_ISCW002159.1.1 m.764 sp KCNT2_HUMAN 44.382 178 99 0 1 178 257 434 3.00E-51 181 KCNT2_HUMAN reviewed Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Homo sapiens (Human) 1135 0 GO:0005249; GO:0005524; GO:0008076; GO:0015269 0 0 0 PF03493;PF07885; Q6ZNB5 CHOYP_BRAFLDRAFT_123617.1.1 m.6682 sp TRC2L_HUMAN 41.964 112 64 1 1 111 1 112 3.00E-23 99 TRC2L_HUMAN reviewed Putative short transient receptor potential channel 2-like protein (TrpC2-like protein) 0 Homo sapiens (Human) 142 single strand break repair [GO:0000012] GO:0000012; GO:0003684; GO:0005634 0 0 0 PF01834; Q8AWF2 CHOYP_NACA.7.9 m.62590 sp NACA_ORENI 74.324 148 30 3 65 204 1 148 3.00E-57 183 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q8HXX6 CHOYP_BRAFLDRAFT_124972.2.5 m.4101 sp SAP3_MACFA 33.526 173 103 4 126 287 16 187 3.00E-29 112 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8IDX6 CHOYP_contig_003937 m.4490 sp RBP2A_PLAF7 44.382 178 95 4 207 383 2704 2878 3.00E-17 91.3 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8QGW7 CHOYP_NEMVEDRAFT_V1G129909.9.9 m.66769 sp LITAF_CHICK 44.348 115 53 3 20 128 39 148 3.00E-24 93.6 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q91WJ8 CHOYP_BRAFLDRAFT_124476.3.4 m.48507 sp FUBP1_MOUSE 50 86 43 0 2 87 96 181 3.00E-22 92.8 FUBP1_MOUSE reviewed Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) Fubp1 D3Ertd330e Mus musculus (Mouse) 651 cell growth [GO:0016049]; hematopoietic stem cell proliferation [GO:0071425]; positive regulation of gene expression [GO:0010628]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; stem cell division [GO:0017145] GO:0001205; GO:0003677; GO:0005634; GO:0005654; GO:0006357; GO:0010628; GO:0016049; GO:0017145; GO:0044822; GO:0071425 0 0 0 PF09005;PF00013; Q92838 CHOYP_LOC100877826.3.4 m.40850 sp EDA_HUMAN 30.508 118 75 5 24 138 273 386 3.00E-07 51.6 EDA_HUMAN reviewed "Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]" EDA ED1 EDA2 Homo sapiens (Human) 391 cell differentiation [GO:0030154]; cell-matrix adhesion [GO:0007160]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; hair follicle placode formation [GO:0060789]; immune response [GO:0006955]; odontogenesis of dentin-containing tooth [GO:0042475]; pigmentation [GO:0043473]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of NIK/NF-kappaB signaling [GO:1901222]; salivary gland cavitation [GO:0060662]; trachea gland development [GO:0061153]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0005102; GO:0005123; GO:0005576; GO:0005581; GO:0005789; GO:0005856; GO:0005886; GO:0005887; GO:0006955; GO:0007160; GO:0010467; GO:0010628; GO:0016020; GO:0016021; GO:0019221; GO:0030154; GO:0033209; GO:0038177; GO:0042346; GO:0042475; GO:0043231; GO:0043473; GO:0045177; GO:0051092; GO:0060662; GO:0060789; GO:0061153; GO:0090263; GO:1901222 0 0 0 PF00229; Q969T9 CHOYP_LOC589108.2.2 m.48073 sp WBP2_HUMAN 50 160 76 4 78 234 1 159 3.00E-40 145 WBP2_HUMAN reviewed WW domain-binding protein 2 (WBP-2) WBP2 Homo sapiens (Human) 261 "cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization [GO:0045184]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000790; GO:0000979; GO:0001105; GO:0031490; GO:0045184; GO:0045815; GO:0045944; GO:0071391; GO:0071442 0 0 0 PF02893; Q9BZE3 CHOYP_BARH1.1.1 m.22107 sp BARH1_HUMAN 49.187 246 93 9 61 298 83 304 3.00E-52 177 BARH1_HUMAN reviewed BarH-like 1 homeobox protein BARHL1 FKSG31 Homo sapiens (Human) 327 midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sensory perception of sound [GO:0007605] GO:0000977; GO:0001077; GO:0001228; GO:0001764; GO:0005634; GO:0006357; GO:0007605; GO:0030901; GO:0043524 0 0 0 PF00046; Q9JIP0 CHOYP_TRPV5.3.3 m.52263 sp TRPV5_RAT 26.873 614 338 19 65 655 73 598 3.00E-36 150 TRPV5_RAT reviewed Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transporter 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) Trpv5 Cat2 Ecac Ecac1 Rattus norvegicus (Rat) 723 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein tetramerization [GO:0051262] GO:0005262; GO:0005887; GO:0006816; GO:0016324; GO:0051262; GO:0060402 0 0 0 PF12796;PF00520; Q9R0W9 CHOYP_LOC100313543.1.2 m.53013 sp ACHA6_MOUSE 29.254 335 213 9 24 346 21 343 3.00E-38 147 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; A2RUV0 CHOYP_LOC100366518.4.6 m.40074 sp NOTC1_XENTR 43.312 314 170 6 1 308 179 490 3.01E-64 242 NOTC1_XENTR reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 2522 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001525; GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; A7MBB8 CHOYP_LOC100891444.1.1 m.4810 sp DOK2_BOVIN 24.506 253 144 8 4 223 5 243 3.01E-06 54.3 DOK2_BOVIN reviewed Docking protein 2 (Downstream of tyrosine kinase 2) DOK2 Bos taurus (Bovine) 413 Ras protein signal transduction [GO:0007265]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005057; GO:0005622; GO:0007169; GO:0007265 0 0 0 PF02174;PF00169; O89094 CHOYP_LOC100632618.3.3 m.35314 sp CASPE_MOUSE 28.205 195 109 7 68 251 58 232 3.01E-13 71.6 CASPE_MOUSE reviewed "Caspase-14 (CASP-14) (EC 3.4.22.-) (Mini-ICE) (MICE) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]" Casp14 Mus musculus (Mouse) 257 cornification [GO:0070268] GO:0005634; GO:0005737; GO:0008233; GO:0045095; GO:0070062; GO:0070268; GO:0097153 0 0 0 0 P22105 CHOYP_BM1_57400.1.7 m.2960 sp TENX_HUMAN 26.929 635 263 46 54 614 243 750 3.01E-24 113 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P23023 CHOYP_DMRT1.1.1 m.48996 sp DSX_DROME 46 50 23 1 16 61 44 93 3.01E-07 55.1 DSX_DROME reviewed Protein doublesex dsx CG11094 Drosophila melanogaster (Fruit fly) 549 "axon midline choice point recognition [GO:0016199]; central nervous system development [GO:0007417]; courtship behavior [GO:0007619]; female analia development [GO:0045497]; female sex differentiation [GO:0046660]; female somatic sex determination [GO:0019101]; genital disc development [GO:0035215]; genital disc morphogenesis [GO:0007483]; genital disc sexually dimorphic development [GO:0035263]; imaginal disc-derived female genitalia development [GO:0007486]; imaginal disc-derived male genitalia development [GO:0007485]; male analia development [GO:0045496]; male courtship behavior [GO:0008049]; male courtship behavior, veined wing generated song production [GO:0045433]; male sex differentiation [GO:0046661]; male somatic sex determination [GO:0019102]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of developmental pigmentation [GO:0048086]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of imaginal disc growth [GO:0045570]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sex comb development [GO:0045498]; sex determination [GO:0007530]; sex differentiation [GO:0007548]; sex-specific pigmentation [GO:0048071]; somatic sex determination [GO:0018993]; spermatogenesis [GO:0007283]" GO:0000122; GO:0000398; GO:0000987; GO:0001077; GO:0001078; GO:0003677; GO:0003700; GO:0003729; GO:0005634; GO:0006355; GO:0006357; GO:0007283; GO:0007417; GO:0007483; GO:0007485; GO:0007486; GO:0007530; GO:0007548; GO:0007619; GO:0008049; GO:0016199; GO:0018993; GO:0019101; GO:0019102; GO:0035215; GO:0035263; GO:0042803; GO:0045433; GO:0045496; GO:0045497; GO:0045498; GO:0045570; GO:0045892; GO:0045893; GO:0045944; GO:0046660; GO:0046661; GO:0046872; GO:0048071; GO:0048086 0 0 0 PF00751;PF08828; P24668 CHOYP_LOC100882726.1.1 m.61695 sp MPRD_MOUSE 34.375 128 80 2 109 232 119 246 3.01E-13 70.9 MPRD_MOUSE reviewed Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6pr 46mpr Mus musculus (Mouse) 278 intracellular protein transport [GO:0006886]; secretion of lysosomal enzymes [GO:0033299] GO:0005537; GO:0005765; GO:0005768; GO:0005770; GO:0005802; GO:0006886; GO:0015578; GO:0016020; GO:0016021; GO:0033299; GO:0048471 0 0 0 PF02157; P29973 CHOYP_NEMVEDRAFT_V1G81021.1.1 m.58060 sp CNGA1_HUMAN 43.975 473 240 6 103 571 158 609 3.01E-135 423 CNGA1_HUMAN reviewed "cGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)" CNGA1 CNCG CNCG1 Homo sapiens (Human) 690 regulation of membrane potential [GO:0042391]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; rhodopsin mediated signaling pathway [GO:0016056]; transport [GO:0006810]; visual perception [GO:0007601] GO:0005222; GO:0005223; GO:0005249; GO:0005886; GO:0005887; GO:0006810; GO:0007601; GO:0016056; GO:0022400; GO:0030553; GO:0042391; GO:0042622 0 0 0 PF16526;PF00027;PF00520; P52164 CHOYP_LOC664267.1.1 m.50587 sp MAX_RAT 53.073 179 49 5 11 179 3 156 3.01E-49 159 MAX_RAT reviewed Protein max (Myc-associated factor X) Max Rattus norvegicus (Rat) 160 "cellular response to peptide hormone stimulus [GO:0071375]; cellular response to starvation [GO:0009267]; negative regulation of gene expression [GO:0010629]; neuron apoptotic process [GO:0051402]; protein complex assembly [GO:0006461]; regulation of transcription, DNA-templated [GO:0006355]; response to axon injury [GO:0048678]; response to insulin [GO:0032868]; response to organonitrogen compound [GO:0010243]; retina development in camera-type eye [GO:0060041]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0000983; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006461; GO:0009267; GO:0010243; GO:0010629; GO:0016605; GO:0030425; GO:0032403; GO:0032868; GO:0042803; GO:0043565; GO:0046982; GO:0048678; GO:0051402; GO:0060041; GO:0071339; GO:0071375 0 0 0 PF00010; P61255 CHOYP_LOC585872.6.6 m.65415 sp RL26_MOUSE 80.714 140 26 1 17 155 1 140 3.01E-80 237 RL26_MOUSE reviewed 60S ribosomal protein L26 (Silica-induced gene 20 protein) (SIG-20) Rpl26 Mus musculus (Mouse) 145 cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0002181; GO:0003735; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0044822; GO:0070062 0 0 0 PF00467;PF16906; P86786 CHOYP_LOC100377195.2.2 m.61720 sp GIGA3_CRAGI 45.05 202 111 0 357 558 2 203 3.01E-58 199 GIGA3_CRAGI reviewed Gigasin-3a (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 284 0 0 0 0 0 0 Q01528 CHOYP_HAAF.4.13 m.13669 sp HAAF_LIMPO 38.462 169 97 4 6 171 4 168 3.01E-37 129 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q0IIZ5 CHOYP_TCTP.2.2 m.20356 sp KBP_XENTR 36.885 122 58 2 1 103 16 137 3.01E-17 78.6 KBP_XENTR reviewed KIF1-binding protein Kif1bp kbp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 616 central nervous system projection neuron axonogenesis [GO:0021952]; efferent axon development in posterior lateral line nerve [GO:0048929]; enteric nervous system development [GO:0048484]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial transport [GO:0006839]; nervous system development [GO:0007399]; neuron projection maintenance [GO:1990535] GO:0000226; GO:0005739; GO:0005856; GO:0006839; GO:0007399; GO:0019894; GO:0021952; GO:0048484; GO:0048929; GO:1990535 0 0 0 PF12309; Q0P5A1 CHOYP_LOC100366786.1.2 m.11671 sp DCTN3_BOVIN 36.667 180 105 2 9 188 10 180 3.01E-37 130 DCTN3_BOVIN reviewed Dynactin subunit 3 DCTN3 Bos taurus (Bovine) 186 cytokinesis [GO:0000910]; microtubule-based process [GO:0007017]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0000910; GO:0005813; GO:0005819; GO:0005869; GO:0007017; GO:0007067; GO:0030496; GO:0032154; GO:0048471 0 0 0 PF07426; Q21828 CHOYP_CRE_20365.3.3 m.62302 sp MPC1_CAEEL 57.407 108 45 1 6 113 20 126 3.01E-41 137 MPC1_CAEEL reviewed Probable mitochondrial pyruvate carrier 1 (MPC1) R07E5.13 Caenorhabditis elegans 137 mitochondrial pyruvate transport [GO:0006850] GO:0005743; GO:0006850; GO:0016021 0 0 0 PF03650; Q29471 CHOYP_BRAFLDRAFT_78683.3.4 m.48596 sp ANX13_CANLF 34.091 308 200 2 657 962 9 315 3.01E-56 200 ANX13_CANLF reviewed Annexin A13 (Annexin XIII) (Annexin-13) (Intestine-specific annexin) (ISA) ANXA13 ANX13 Canis lupus familiaris (Dog) (Canis familiaris) 316 negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998] GO:0001786; GO:0005509; GO:0005544; GO:0005615; GO:0005654; GO:0005886; GO:0016023; GO:0016323; GO:0016324; GO:0042997; GO:0042998; GO:0045121; GO:0070062; GO:0070382; GO:1901611 0 0 0 PF00191; Q3SYR7 CHOYP_SVEP1.5.8 m.35493 sp RL9_BOVIN 64.516 62 21 1 53 113 97 158 3.01E-20 84 RL9_BOVIN reviewed 60S ribosomal protein L9 RPL9 Bos taurus (Bovine) 192 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003723; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00347; Q3ULZ2 CHOYP_BRAFLDRAFT_122887.1.1 m.62170 sp FHDC1_MOUSE 35.714 406 251 6 523 925 95 493 3.01E-75 278 FHDC1_MOUSE reviewed FH2 domain-containing protein 1 Fhdc1 Kiaa1727 Mus musculus (Mouse) 1149 0 0 0 0 0 PF02181; Q5TYV4 CHOYP_SPE39.1.1 m.23443 sp SPE39_DANRE 37.426 505 280 9 7 497 1 483 3.01E-93 294 SPE39_DANRE reviewed Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) vipas39 spe39 vipar si:ch211-20b12.1 Danio rerio (Zebrafish) (Brachydanio rerio) 483 "cell differentiation [GO:0030154]; hepaticobiliary system development [GO:0061008]; intracellular protein transport [GO:0006886]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0005769; GO:0005770; GO:0006351; GO:0006355; GO:0006886; GO:0007283; GO:0016023; GO:0030154; GO:0055037; GO:0061008 0 0 0 PF04840; Q96M20 CHOYP_LOC101242145.1.1 m.48268 sp CNBD2_HUMAN 25.106 235 169 4 389 622 64 292 3.01E-17 89.7 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96WV6 CHOYP_contig_036780 m.41389 sp YHU2_SCHPO 28.931 318 205 4 16 315 1244 1558 3.01E-18 89 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q9JJ25 CHOYP_BRAFLDRAFT_71616.1.3 m.658 sp MEFV_RAT 26.531 147 83 3 18 163 443 565 3.01E-06 53.1 MEFV_RAT reviewed Pyrin (Marenostrin) Mefv Rattus norvegicus (Rat) 750 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; response to interferon-gamma [GO:0034341]; response to lipopolysaccharide [GO:0032496]; response to silicon dioxide [GO:0034021] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032496; GO:0034021; GO:0034341; GO:1900016; GO:1900226 0 0 0 PF02758;PF00643; Q9NUV9 CHOYP_GIMAP4.1.4 m.22209 sp GIMA4_HUMAN 41.071 280 156 4 94 370 28 301 3.01E-60 204 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9SN68 CHOYP_TVAG_169740.1.1 m.43757 sp RAF2B_ARATH 41.053 190 109 2 13 201 11 198 3.01E-46 154 RAF2B_ARATH reviewed Ras-related protein RABF2b (AtRABF2b) (Ras-related protein Ara-7) (Ras-related protein Rab5B) (AtRab5B) RABF2B ARA-7 RAB5B At4g19640 F24J7.190 Arabidopsis thaliana (Mouse-ear cress) 200 endocytosis [GO:0006897]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005768; GO:0005769; GO:0005783; GO:0005886; GO:0006897; GO:0007264; GO:0030139; GO:0031901 0 0 0 PF00071; Q9ULJ7 CHOYP_LOC755521.28.28 m.67022 sp ANR50_HUMAN 38.813 219 134 0 4 222 719 937 3.01E-40 149 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VUL9 CHOYP_ISCW_ISCW004236.3.5 m.11201 sp FUCTA_DROME 36.066 305 164 14 87 381 188 471 3.01E-42 158 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q9Y2M2 CHOYP_BRAFLDRAFT_276314.2.3 m.51656 sp SSUH2_HUMAN 32.827 329 201 5 47 370 39 352 3.01E-63 208 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 A3KPW9 CHOYP_BAG6.1.1 m.2349 sp BAG6_DANRE 29.6 125 83 2 396 515 734 858 3.02E-11 70.1 BAG6_DANRE reviewed Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3) Bag6 Bat3 si:ch211-215a10.6 Danio rerio (Zebrafish) (Brachydanio rerio) 1160 brain development [GO:0007420]; covalent chromatin modification [GO:0016569]; embryo development [GO:0009790]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; transport [GO:0006810]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001822; GO:0005634; GO:0005829; GO:0006511; GO:0006810; GO:0007130; GO:0007283; GO:0007420; GO:0009790; GO:0016569; GO:0018393; GO:0030324; GO:0031593; GO:0032435; GO:0042771; GO:0042981; GO:0043022; GO:0045861; GO:0050821; GO:0070059; GO:0070628; GO:0071816; GO:0071818 0 0 0 PF12057;PF00240; F6QEU4 CHOYP_BRAFLDRAFT_82868.2.5 m.39030 sp LIN41_XENTR 25.941 239 128 10 12 214 146 371 3.02E-09 62 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O14975 CHOYP_S27A4.1.2 m.5860 sp S27A2_HUMAN 41.28 453 247 7 1 446 61 501 3.02E-110 341 S27A2_HUMAN reviewed "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) 620 bile acid biosynthetic process [GO:0006699]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; very long-chain fatty acid catabolic process [GO:0042760] GO:0001561; GO:0001676; GO:0004467; GO:0005102; GO:0005524; GO:0005739; GO:0005778; GO:0005779; GO:0005788; GO:0005789; GO:0006635; GO:0006699; GO:0015245; GO:0019899; GO:0030176; GO:0031957; GO:0042760; GO:0044539; GO:0050197; GO:0070062; GO:0070251; GO:0097089; GO:0102391 0 0 0 PF00501;PF13193; O15381 CHOYP_PHUM_PHUM563970.1.1 m.13515 sp NVL_HUMAN 66.077 339 112 2 673 1009 517 854 3.02E-146 460 NVL_HUMAN reviewed Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) NVL Homo sapiens (Human) 856 positive regulation of telomerase activity [GO:0051973]; ribosome biogenesis [GO:0042254] GO:0005524; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0005739; GO:0016020; GO:0042254; GO:0044822; GO:0051973; GO:1990275 0 0 0 PF00004;PF16725; O43736 CHOYP_CG3662.1.2 m.22861 sp ITM2A_HUMAN 36.364 110 62 3 5 112 116 219 3.02E-14 71.2 ITM2A_HUMAN reviewed Integral membrane protein 2A (Protein E25) ITM2A UNQ603/PRO1189 Homo sapiens (Human) 263 negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399] GO:0001540; GO:0005794; GO:0005886; GO:0007399; GO:0016021; GO:0042985; GO:0070062 0 0 0 PF04089; O70277 CHOYP_BRAFLDRAFT_87327.4.13 m.32980 sp TRIM3_RAT 26.829 123 85 3 129 247 622 743 3.02E-07 55.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O73746 CHOYP_TIMP3.5.9 m.39776 sp TIMP3_XENLA 33.962 106 63 4 9 113 12 111 3.02E-06 48.5 TIMP3_XENLA reviewed Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) timp3 Xenopus laevis (African clawed frog) 214 0 GO:0005578; GO:0008191; GO:0046872 0 0 0 PF00965; P16157 CHOYP_LOC583072.15.25 m.53381 sp ANK1_HUMAN 30.126 634 425 6 714 1346 171 787 3.02E-77 286 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22856 CHOYP_DICPUDRAFT_84282.1.1 m.49375 sp VL96_IRV1 30.178 169 89 4 374 526 595 750 3.02E-11 72 VL96_IRV1 reviewed Putative ubiquitin thioesterase L96 (EC 3.4.19.12) L96 Tipula iridescent virus (TIV) (Insect iridescent virus type 1) 867 "DNA-templated transcription, termination [GO:0006353]; viral release from host cell [GO:0019076]" GO:0003677; GO:0006353; GO:0019076; GO:0036459 0 0 0 PF02338; P48032 CHOYP_TIMP2B.1.1 m.29629 sp TIMP3_RAT 30.303 132 85 4 4 132 8 135 3.02E-08 55.1 TIMP3_RAT reviewed Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) Timp3 Timp-3 Rattus norvegicus (Rat) 211 aging [GO:0007568]; central nervous system development [GO:0007417]; negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of proteolysis [GO:0045861]; response to amino acid [GO:0043200]; response to estrogen [GO:0043627]; response to folic acid [GO:0051593]; response to hormone [GO:0009725]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; tissue regeneration [GO:0042246] GO:0002020; GO:0005578; GO:0005615; GO:0005737; GO:0007417; GO:0007568; GO:0008191; GO:0009612; GO:0009725; GO:0010033; GO:0014070; GO:0042246; GO:0043086; GO:0043200; GO:0043627; GO:0045861; GO:0046872; GO:0051045; GO:0051593 0 0 0 PF00965; P55210 CHOYP_XCASPASE-7.2.4 m.41180 sp CASP7_HUMAN 29.344 259 137 12 12 248 67 301 3.02E-16 79.7 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P62494 CHOYP_BRAFLDRAFT_266781.1.2 m.24881 sp RB11A_RAT 88.785 214 23 1 1 214 1 213 3.02E-139 391 RB11A_RAT reviewed Ras-related protein Rab-11A (Rab-11) (24KG) Rab11a Rab11 Rattus norvegicus (Rat) 216 astral microtubule organization [GO:0030953]; cytokinesis [GO:0000910]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of multivesicular body size [GO:0010796]; regulation of protein transport [GO:0051223]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264] GO:0000910; GO:0000922; GO:0003924; GO:0005525; GO:0005739; GO:0005771; GO:0005802; GO:0005813; GO:0005828; GO:0005886; GO:0006887; GO:0007080; GO:0007264; GO:0010634; GO:0010796; GO:0010971; GO:0015031; GO:0030133; GO:0030424; GO:0030953; GO:0031175; GO:0032154; GO:0032402; GO:0036258; GO:0043234; GO:0045335; GO:0045773; GO:0048169; GO:0048471; GO:0051223; GO:0055037; GO:0055038; GO:0060627; GO:0070062; GO:0072594; GO:0072659; GO:0090150; GO:0090307; GO:1990182 0 0 0 PF00071; P62494 CHOYP_BRAFLDRAFT_266781.2.2 m.44660 sp RB11A_RAT 88.785 214 23 1 1 214 1 213 3.02E-139 391 RB11A_RAT reviewed Ras-related protein Rab-11A (Rab-11) (24KG) Rab11a Rab11 Rattus norvegicus (Rat) 216 astral microtubule organization [GO:0030953]; cytokinesis [GO:0000910]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanosome transport [GO:0032402]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of multivesicular body size [GO:0010796]; regulation of protein transport [GO:0051223]; regulation of vesicle-mediated transport [GO:0060627]; small GTPase mediated signal transduction [GO:0007264] GO:0000910; GO:0000922; GO:0003924; GO:0005525; GO:0005739; GO:0005771; GO:0005802; GO:0005813; GO:0005828; GO:0005886; GO:0006887; GO:0007080; GO:0007264; GO:0010634; GO:0010796; GO:0010971; GO:0015031; GO:0030133; GO:0030424; GO:0030953; GO:0031175; GO:0032154; GO:0032402; GO:0036258; GO:0043234; GO:0045335; GO:0045773; GO:0048169; GO:0048471; GO:0051223; GO:0055037; GO:0055038; GO:0060627; GO:0070062; GO:0072594; GO:0072659; GO:0090150; GO:0090307; GO:1990182 0 0 0 PF00071; P81942 CHOYP_LOC100378099.1.1 m.22677 sp GSTP1_BUFBU 47.317 205 105 1 6 207 5 209 3.02E-58 185 GSTP1_BUFBU reviewed Glutathione S-transferase P 1 (EC 2.5.1.18) (BBGSTP1-1) (GST class-pi) 0 Bufo bufo (European toad) 210 metabolic process [GO:0008152] GO:0004364; GO:0005634; GO:0005739; GO:0008152 0 0 0 PF14497;PF02798; Q14162 CHOYP_LOC101068272.3.3 m.48286 sp SREC_HUMAN 33.835 133 68 6 36 155 213 338 3.02E-11 67 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q14656 CHOYP_LOC100375233.1.1 m.17835 sp TM187_HUMAN 35.918 245 146 4 6 250 7 240 3.02E-43 150 TM187_HUMAN reviewed Transmembrane protein 187 (Protein ITBA1) TMEM187 CXorf12 DXS9878E ITBA1 Homo sapiens (Human) 261 0 GO:0016021; GO:0030133 0 0 0 PF15100; Q20758 CHOYP_SMP_088650.1.3 m.10770 sp ARL1_CAEEL 44.118 170 95 0 10 179 1 170 3.02E-47 155 ARL1_CAEEL reviewed ADP-ribosylation factor-like protein 1 arl-1 F54C9.10 Caenorhabditis elegans 180 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q24498 CHOYP_RYR2.1.1 m.2913 sp RYR_DROME 74 150 38 1 10 158 29 178 3.02E-72 239 RYR_DROME reviewed Ryanodine receptor (Ryanodine receptor 44F) RyR dry Rya-r44F CG10844 Drosophila melanogaster (Fruit fly) 5127 calcium ion transport [GO:0006816]; heart contraction [GO:0060047]; multicellular organism development [GO:0007275]; muscle contraction [GO:0006936]; regulation of hemocyte proliferation [GO:0035206]; response to anesthetic [GO:0072347] GO:0005219; GO:0005875; GO:0006816; GO:0006936; GO:0007275; GO:0016021; GO:0033017; GO:0035206; GO:0060047; GO:0072347 0 0 0 PF08709;PF00520;PF02815;PF08454;PF06459;PF01365;PF02026;PF00622; Q24K15 CHOYP_LOC100313602.2.2 m.46627 sp ANGP4_BOVIN 37.054 224 118 6 108 321 285 495 3.02E-38 144 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q460N5 CHOYP_PARP14.13.22 m.51246 sp PAR14_HUMAN 35.714 182 112 3 96 275 798 976 3.02E-28 120 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q502M6 CHOYP_LOC754035.6.6 m.61137 sp ANR29_DANRE 38.406 138 85 0 15 152 47 184 3.02E-26 103 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5F477 CHOYP_BRAFLDRAFT_242424.2.2 m.31851 sp LDAH_CHICK 42.857 322 163 5 5 305 3 324 3.02E-84 259 LDAH_CHICK reviewed Lipid droplet-associated hydrolase (EC 3.1.1.-) (Lipid droplet-associated serine hydrolase) LDAH RCJMB04_2g19 Gallus gallus (Chicken) 324 lipid storage [GO:0019915] GO:0005783; GO:0005811; GO:0016298; GO:0019915 0 0 0 0 Q7TSU7 CHOYP_DVIR_GJ19783.3.3 m.49476 sp KIRR2_MOUSE 23.567 314 217 9 111 411 91 394 3.02E-17 90.5 KIRR2_MOUSE reviewed Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) Kirrel2 Neph3 Mus musculus (Mouse) 700 negative regulation of protein phosphorylation [GO:0001933]; single organismal cell-cell adhesion [GO:0016337] GO:0001933; GO:0005886; GO:0005911; GO:0016021; GO:0016337; GO:0036057 0 0 0 PF08205;PF07679; Q86Y13 CHOYP_LOC100372716.9.10 m.54717 sp DZIP3_HUMAN 26.846 149 102 3 22 164 393 540 3.02E-06 55.5 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8IVG5 CHOYP_BRAFLDRAFT_131039.9.9 m.57043 sp SAM9L_HUMAN 31.405 121 73 4 60 170 687 807 3.02E-08 61.2 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q8TC21 CHOYP_ZN583.2.2 m.62430 sp ZN596_HUMAN 36.652 221 133 2 8 227 287 501 3.02E-39 153 ZN596_HUMAN reviewed Zinc finger protein 596 ZNF596 Homo sapiens (Human) 504 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q91YD4 CHOYP_TRPM2.6.12 m.36669 sp TRPM2_MOUSE 22.343 734 458 25 1 665 196 886 3.02E-35 147 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q9BQS2 CHOYP_SYT15.1.1 m.22060 sp SYT15_HUMAN 35.948 306 184 6 152 453 123 420 3.02E-54 189 SYT15_HUMAN reviewed Synaptotagmin-15 (Chr10Syt) (Synaptotagmin XV) (SytXV) SYT15 Homo sapiens (Human) 421 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019905; GO:0030276; GO:0048791; GO:0098793 0 0 0 PF00168; Q9GJT6 CHOYP_LOC101067849.1.1 m.38733 sp SC6A3_MACFA 50 104 47 3 103 205 16 115 3.02E-22 99.4 SC6A3_MACFA reviewed Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3) SLC6A3 DAT1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 620 dopamine transport [GO:0015872] GO:0005329; GO:0005330; GO:0005887; GO:0015872; GO:0046872 0 0 0 PF00209; Q9QYP1 CHOYP_LOC100374813.1.2 m.35099 sp LRP4_RAT 31.973 294 194 5 84 375 1353 1642 3.02E-42 168 LRP4_RAT reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) Lrp4 Megf7 Rattus norvegicus (Rat) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0034185; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; A8Y5U1 CHOYP_CZH5ORF51.1.1 m.25147 sp CE051_DANRE 39.091 220 121 5 70 282 63 276 3.03E-41 146 CE051_DANRE reviewed UPF0600 protein C5orf51 homolog si:dkey-46a10.3 wu:fd42g01 Danio rerio (Zebrafish) (Brachydanio rerio) 276 0 0 0 0 0 0 A9ULZ2 CHOYP_LOC100560580.1.2 m.9193 sp BIR7B_XENLA 29.973 377 177 10 24 391 46 344 3.03E-50 175 BIR7B_XENLA reviewed Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) 345 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; D4AR77 CHOYP_LOC100893261.2.3 m.49437 sp A6907_ARTBC 24.289 457 274 20 60 472 83 511 3.03E-12 72.8 A6907_ARTBC reviewed Uncharacterized secreted protein ARB_06907 ARB_06907 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) 930 0 GO:0005576; GO:0008236 0 0 0 PF00326; E7F568 CHOYP_LOC100487213.1.4 m.23247 sp COBL_DANRE 26.957 230 141 6 68 293 59 265 3.03E-14 81.6 COBL_DANRE reviewed Protein cordon-bleu cobl Danio rerio (Zebrafish) (Brachydanio rerio) 1343 actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; auditory receptor cell stereocilium organization [GO:0060088]; cilium morphogenesis [GO:0060271]; heart jogging [GO:0003146]; heart looping [GO:0001947] GO:0001726; GO:0001947; GO:0003146; GO:0003785; GO:0005829; GO:0005856; GO:0005886; GO:0030041; GO:0051639; GO:0060088; GO:0060271 0 0 0 PF09469;PF02205; O70277 CHOYP_BRAFLDRAFT_109857.1.15 m.3214 sp TRIM3_RAT 26.829 123 85 3 121 239 622 743 3.03E-07 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P02637 CHOYP_SCP.6.12 m.50694 sp SCP_MIZYE 51.705 176 82 3 23 198 2 174 3.03E-59 186 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P19477 CHOYP_BRAFLDRAFT_86061.8.13 m.50941 sp FIBA_PARPA 45.192 104 57 0 72 175 50 153 3.03E-24 98.6 FIBA_PARPA reviewed Fibrinogen-like protein A (FREP-A) 0 Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) 282 0 0 0 0 0 PF00147; P23206 CHOYP_LOC100023678.1.1 m.39546 sp COAA1_BOVIN 45.752 153 63 4 116 255 305 450 3.03E-16 83.2 COAA1_BOVIN reviewed Collagen alpha-1(X) chain COL10A1 Bos taurus (Bovine) 674 0 GO:0005576; GO:0005578; GO:0005581 0 0 0 PF00386;PF01391; P26652 CHOYP_RS23.2.9 m.19906 sp TIMP3_CHICK 30.682 176 108 7 43 206 22 195 3.03E-15 74.3 TIMP3_CHICK reviewed Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) 212 negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] GO:0002020; GO:0005578; GO:0005615; GO:0008191; GO:0010033; GO:0043086; GO:0046872; GO:0051045 0 0 0 PF00965; P29503 CHOYP_NEU1B.1.1 m.59912 sp NEUR_DROME 46.341 164 87 1 66 229 357 519 3.03E-49 180 NEUR_DROME reviewed Protein neuralized neur neu CG11988 Drosophila melanogaster (Fruit fly) 754 asymmetric cell division [GO:0008356]; brain morphogenesis [GO:0048854]; compound eye development [GO:0048749]; ectoderm development [GO:0007398]; germ-line stem cell population maintenance [GO:0030718]; imaginal disc-derived wing morphogenesis [GO:0007476]; inter-male aggressive behavior [GO:0002121]; lateral inhibition [GO:0046331]; locomotion involved in locomotory behavior [GO:0031987]; long-term memory [GO:0007616]; mesoderm development [GO:0007498]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; olfactory behavior [GO:0042048]; ovarian follicle cell development [GO:0030707]; peripheral nervous system development [GO:0007422]; positive regulation of Notch signaling pathway [GO:0045747]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; regulation of compound eye photoreceptor development [GO:0045314]; regulation of Notch signaling pathway [GO:0008593]; regulation of photoreceptor cell differentiation [GO:0046532]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]; startle response [GO:0001964]; ventral cord development [GO:0007419] GO:0000209; GO:0001964; GO:0002121; GO:0003677; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007219; GO:0007398; GO:0007399; GO:0007419; GO:0007422; GO:0007423; GO:0007476; GO:0007498; GO:0007616; GO:0008104; GO:0008270; GO:0008356; GO:0008593; GO:0016360; GO:0030707; GO:0030718; GO:0031987; GO:0042048; GO:0045314; GO:0045747; GO:0046331; GO:0046532; GO:0048471; GO:0048749; GO:0048854; GO:0051260; GO:0061630; GO:1901981 0 0 0 PF07177; P35570 CHOYP_BRAFLDRAFT_124878.1.1 m.55561 sp IRS1_RAT 43.874 253 109 5 30 249 11 263 3.03E-57 221 IRS1_RAT reviewed Insulin receptor substrate 1 (IRS-1) (pp185) Irs1 Irs-1 Rattus norvegicus (Rat) 1235 aging [GO:0007568]; cellular response to angiotensin [GO:1904385]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to radiation [GO:0071478]; insulin-like growth factor receptor signaling pathway [GO:0048009]; insulin receptor signaling pathway [GO:0008286]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin secretion [GO:0046676]; negative regulation of somatostatin secretion [GO:0090275]; positive regulation of glucagon secretion [GO:0070094]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphorylation [GO:0042327]; protein heterooligomerization [GO:0051291]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to peptide hormone [GO:0043434] GO:0005068; GO:0005080; GO:0005158; GO:0005159; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005899; GO:0007568; GO:0008286; GO:0014823; GO:0019901; GO:0019904; GO:0031000; GO:0042169; GO:0042327; GO:0043231; GO:0043434; GO:0043548; GO:0043552; GO:0046627; GO:0046628; GO:0046676; GO:0048009; GO:0051291; GO:0060397; GO:0070094; GO:0071478; GO:0090275; GO:1904385; GO:1990416 0 0 cd01204; PF02174;PF00169; P43006 CHOYP_EAA2.2.3 m.45212 sp EAA2_MOUSE 33.008 512 308 7 43 523 35 542 3.03E-88 285 EAA2_MOUSE reviewed Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Slc1a2 Eaat2 Glt1 Mus musculus (Mouse) 572 adult behavior [GO:0030534]; anion transmembrane transport [GO:0098656]; cellular response to extracellular stimulus [GO:0031668]; D-aspartate import [GO:0070779]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0089711]; L-glutamate transport [GO:0015813]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; positive regulation of glucose import [GO:0046326]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; telencephalon development [GO:0021537]; visual behavior [GO:0007632] GO:0005313; GO:0005886; GO:0005887; GO:0007399; GO:0007632; GO:0008509; GO:0009416; GO:0009611; GO:0009986; GO:0010259; GO:0015501; GO:0015813; GO:0021537; GO:0030424; GO:0030534; GO:0030673; GO:0031668; GO:0035264; GO:0042493; GO:0043200; GO:0046326; GO:0051938; GO:0070779; GO:0089711; GO:0098656 0 0 0 PF00375; P46023 CHOYP_GR101.1.3 m.24739 sp GR101_LYMST 35.972 720 384 13 730 1387 370 1074 3.03E-124 419 GR101_LYMST reviewed G-protein coupled receptor GRL101 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 1115 0 GO:0005886; GO:0016021; GO:0016500 0 0 0 PF00001;PF00057;PF12799;PF13855; P50430 CHOYP_BRAFLDRAFT_206907.9.11 m.46928 sp ARSB_RAT 42.6 500 244 8 37 499 32 525 3.03E-132 396 ARSB_RAT reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb Rattus norvegicus (Rat) 528 autophagy [GO:0006914]; central nervous system development [GO:0007417]; colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005791; GO:0005794; GO:0006914; GO:0007417; GO:0007584; GO:0008152; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0043627; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; P83088 CHOYP_TSP_00082.1.1 m.58886 sp FUCTC_DROME 30.065 306 158 14 52 321 99 384 3.03E-29 120 FUCTC_DROME reviewed "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) 425 protein glycosylation [GO:0006486] GO:0006486; GO:0008417; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; P86854 CHOYP_CLEC4E.1.1 m.44858 sp PLCL_MYTGA 28.125 160 106 5 2 159 4 156 3.03E-10 58.5 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q04164 CHOYP_KCP.1.13 m.5090 sp SAS_DROME 25.455 220 111 10 127 336 532 708 3.03E-08 60.1 SAS_DROME reviewed Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) 1693 axon guidance [GO:0007411]; instar larval development [GO:0002168] GO:0002168; GO:0004872; GO:0005887; GO:0007411; GO:0016324 0 0 0 PF00041; Q4LDE5 CHOYP_LOC580251.3.5 m.37694 sp SVEP1_HUMAN 25.532 188 130 6 33 215 644 826 3.03E-09 60.5 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5R4R9 CHOYP_LOC661955.1.1 m.37858 sp NDUF4_PONAB 26.111 180 120 6 1 173 1 174 3.03E-11 62.8 NDUF4_PONAB reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa homolog) (Protein HRPAP20) NDUFAF4 HRPAP20 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 175 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005739; GO:0016020; GO:0032981 0 0 0 PF06784; Q6DK93 CHOYP_LOC100178777.1.1 m.40771 sp CNFN_XENTR 35.455 110 59 4 171 276 5 106 3.03E-11 62.4 CNFN_XENTR reviewed Cornifelin homolog cnfn TNeu057a17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 111 0 0 0 0 0 PF04749; Q6NWZ9 CHOYP_CDO1.1.4 m.26664 sp CDO1_DANRE 56.15 187 81 1 21 207 6 191 3.03E-82 246 CDO1_DANRE reviewed Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) cdo1 Danio rerio (Zebrafish) (Brachydanio rerio) 201 "L-cysteine catabolic process to pyruvate, using cysteine dioxygenase [GO:0019451]; sulfur amino acid biosynthetic process [GO:0000097]; taurine biosynthetic process [GO:0042412]" GO:0000097; GO:0005506; GO:0005829; GO:0017172; GO:0019451; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. 0 0 PF05995; Q6NYE2 CHOYP_BRAFLDRAFT_67459.1.2 m.1461 sp RCC2_DANRE 56.637 113 49 0 1 113 380 492 3.03E-38 137 RCC2_DANRE reviewed Protein RCC2 homolog rcc2 zgc:77115 Danio rerio (Zebrafish) (Brachydanio rerio) 495 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; neural crest cell migration [GO:0001755] GO:0001755; GO:0005730; GO:0007067; GO:0051301 0 0 0 PF00415; Q7ZXT3 CHOYP_LOC100374995.3.3 m.61282 sp EDC4_XENLA 44.444 63 33 1 115 177 74 134 3.03E-10 61.6 EDC4_XENLA reviewed Enhancer of mRNA-decapping protein 4 edc4 Xenopus laevis (African clawed frog) 1391 0 GO:0000932; GO:0005634 0 0 0 PF16529; Q80XI3 CHOYP_IF4G3.1.1 m.61314 sp IF4G3_MOUSE 40.722 803 378 18 1 736 807 1578 3.03E-171 535 IF4G3_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Eif4g3 Mus musculus (Mouse) 1579 positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283] GO:0001934; GO:0003743; GO:0007283; GO:0044822; GO:0045727; GO:0060903 0 0 0 PF02847;PF02854;PF02020; Q86YI8 CHOYP_LOC100369478.1.1 m.54657 sp PHF13_HUMAN 68.421 76 23 1 98 172 222 297 3.03E-32 120 PHF13_HUMAN reviewed PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1) PHF13 Homo sapiens (Human) 300 cell division [GO:0051301]; chromosome segregation [GO:0007059]; covalent chromatin modification [GO:0016569]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076] GO:0000278; GO:0003682; GO:0005634; GO:0005654; GO:0007059; GO:0007076; GO:0008270; GO:0016569; GO:0035064; GO:0051301 0 0 0 PF00628; Q8AWF2 CHOYP_NACA.8.9 m.64138 sp NACA_ORENI 71.622 222 44 5 16 225 1 215 3.03E-85 254 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q8CI78 CHOYP_PHUM_PHUM214100.1.1 m.14345 sp RMND1_MOUSE 35.664 286 171 6 101 381 172 449 3.03E-50 178 RMND1_MOUSE reviewed Required for meiotic nuclear division protein 1 homolog Rmnd1 Mus musculus (Mouse) 450 positive regulation of mitochondrial translation [GO:0070131]; translation [GO:0006412] GO:0005739; GO:0006412; GO:0070131 0 0 0 PF02582; Q8WZ42 CHOYP_LOC658092.2.2 m.60940 sp TITIN_HUMAN 30.303 198 132 3 664 861 6 197 3.03E-17 92.4 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q96GP6 CHOYP_LOC100707338.2.5 m.20842 sp SREC2_HUMAN 37.363 182 107 6 163 344 245 419 3.03E-27 116 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9BXX0 CHOYP_C1QL2.27.32 m.53618 sp EMIL2_HUMAN 31.469 143 83 4 260 389 907 1047 3.03E-07 56.2 EMIL2_HUMAN reviewed EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) 1053 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030023; GO:0031012 0 0 0 PF00386;PF07546; Q9BYB0 CHOYP_SHANK2.1.1 m.41270 sp SHAN3_HUMAN 51.399 393 182 4 55 440 8 398 3.03E-118 418 SHAN3_HUMAN reviewed SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) SHANK3 KIAA1650 PROSAP2 PSAP2 Homo sapiens (Human) 1731 "adult behavior [GO:0030534]; AMPA glutamate receptor clustering [GO:0097113]; brain morphogenesis [GO:0048854]; dendritic spine morphogenesis [GO:0060997]; guanylate kinase-associated protein clustering [GO:0097117]; learning [GO:0007612]; MAPK cascade [GO:0000165]; memory [GO:0007613]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of cell volume [GO:0045794]; NMDA glutamate receptor clustering [GO:0097114]; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000969]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of glutamate receptor signaling pathway [GO:1900451]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of synapse structural plasticity [GO:0051835]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density assembly [GO:0097107]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of long term synaptic depression [GO:1900452]; regulation of long-term synaptic potentiation [GO:1900271]; social behavior [GO:0035176]; striatal medium spiny neuron differentiation [GO:0021773]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]; vocal learning [GO:0042297]" GO:0000165; GO:0005737; GO:0005886; GO:0007416; GO:0007612; GO:0007613; GO:0008022; GO:0008270; GO:0014069; GO:0017124; GO:0021773; GO:0030054; GO:0030160; GO:0030534; GO:0032232; GO:0035176; GO:0035255; GO:0042297; GO:0042802; GO:0043005; GO:0043197; GO:0044309; GO:0045211; GO:0045794; GO:0048170; GO:0048854; GO:0051835; GO:0051968; GO:0060170; GO:0060997; GO:0060999; GO:0061001; GO:0071625; GO:0097107; GO:0097110; GO:0097113; GO:0097114; GO:0097117; GO:1900271; GO:1900273; GO:1900451; GO:1900452; GO:2000463; GO:2000969 0 0 0 PF12796;PF16511;PF00595;PF00536;PF07653; Q9CQP2 CHOYP_BRAFLDRAFT_279668.1.1 m.21404 sp TPPC2_MOUSE 72.143 140 37 1 1 140 1 138 3.03E-73 218 TPPC2_MOUSE reviewed Trafficking protein particle complex subunit 2 (Sedlin) Trappc2 Sedl Mus musculus (Mouse) 140 "ER to Golgi vesicle-mediated transport [GO:0006888]; regulation of transcription, DNA-templated [GO:0006355]; skeletal system development [GO:0001501]; transcription, DNA-templated [GO:0006351]" GO:0001501; GO:0005634; GO:0005783; GO:0005794; GO:0006351; GO:0006355; GO:0006888; GO:0008134; GO:0030008; GO:0044325; GO:0048471 0 0 0 PF04628; Q9DFR6 CHOYP_SRC1.1.1 m.63626 sp RS13_GILMI 90.741 108 10 0 6 113 1 108 3.03E-69 207 RS13_GILMI reviewed 40S ribosomal protein S13 rps13 Gillichthys mirabilis (Long-jawed mudsucker) 151 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00353; PF08069;PF00312; A2RUV0 CHOYP_AGAP_AGAP002739.3.5 m.47030 sp NOTC1_XENTR 32.357 649 350 22 144 734 242 859 3.04E-67 257 NOTC1_XENTR reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 2522 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001525; GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; O43301 CHOYP_LOC100207121.2.9 m.36465 sp HS12A_HUMAN 25.477 577 306 18 378 890 2 518 3.04E-40 162 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O60462 CHOYP_NRP2.5.8 m.47288 sp NRP2_HUMAN 29.958 237 137 11 86 309 45 265 3.04E-19 93.6 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O70277 CHOYP_contig_045361 m.52729 sp TRIM3_RAT 25.833 120 84 3 58 173 625 743 3.04E-06 50.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_102372.2.2 m.53851 sp TRIM3_HUMAN 26.222 225 141 10 129 342 534 744 3.04E-08 58.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O93430 CHOYP_HYOU1.3.3 m.28441 sp GLRA1_DANRE 23.775 408 261 12 16 395 45 430 3.04E-31 127 GLRA1_DANRE reviewed Glycine receptor subunit alphaZ1 glra1 Danio rerio (Zebrafish) (Brachydanio rerio) 444 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; central nervous system development [GO:0007417]; ion transport [GO:0006811]; neuropeptide signaling pathway [GO:0007218]; protein homooligomerization [GO:0051260]; regulation of neuron differentiation [GO:0045664]; response to amino acid [GO:0043200]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0006811; GO:0007218; GO:0007417; GO:0008270; GO:0016021; GO:0016594; GO:0016934; GO:0022824; GO:0030054; GO:0030425; GO:0034707; GO:0043200; GO:0043204; GO:0045211; GO:0045664; GO:0051260; GO:0060012; GO:0071230; GO:0071294; GO:0071361 0 0 0 PF02931;PF02932; P01040 CHOYP_CYTA.1.1 m.10540 sp CYTA_HUMAN 38 100 54 2 10 106 4 98 3.04E-16 71.2 CYTA_HUMAN reviewed "Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]" CSTA STF1 STFA Homo sapiens (Human) 98 keratinocyte differentiation [GO:0030216]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; peptide cross-linking [GO:0018149]; single organismal cell-cell adhesion [GO:0016337] GO:0001533; GO:0002020; GO:0004869; GO:0005198; GO:0005615; GO:0005634; GO:0005737; GO:0010466; GO:0016337; GO:0018149; GO:0030216; GO:0030674; GO:0031012; GO:0045861; GO:0070062 0 0 0 PF00031; P27657 CHOYP_PNLIPRP3.2.3 m.54774 sp LIPP_RAT 36.688 308 165 8 436 716 42 346 3.04E-48 180 LIPP_RAT reviewed Pancreatic triacylglycerol lipase (PL) (Pancreatic lipase) (EC 3.1.1.3) Pnlip Rattus norvegicus (Rat) 465 lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; post-embryonic development [GO:0009791]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005615; GO:0006629; GO:0009791; GO:0016042; GO:0016298; GO:0033993; GO:0043434; GO:0046872 0 0 0 PF00151;PF01477; P50430 CHOYP_LOC100375292.1.1 m.20844 sp ARSB_RAT 41.509 477 236 7 19 457 34 505 3.04E-126 387 ARSB_RAT reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb Rattus norvegicus (Rat) 528 autophagy [GO:0006914]; central nervous system development [GO:0007417]; colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005791; GO:0005794; GO:0006914; GO:0007417; GO:0007584; GO:0008152; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0043627; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; P70193 CHOYP_CAOG_03185.1.1 m.60277 sp LRIG1_MOUSE 26.328 433 266 11 152 580 133 516 3.04E-19 96.7 LRIG1_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) Lrig1 Mus musculus (Mouse) 1091 innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605] GO:0007605; GO:0016021; GO:0032474; GO:0060384 0 0 0 PF07679;PF13855;PF01463;PF01462; P74148 CHOYP_NEMVEDRAFT_V1G244537.3.3 m.12978 sp Y1388_SYNY3 22 150 110 1 7 149 5 154 3.04E-08 53.1 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P78318 CHOYP_LOC100694272.1.1 m.19247 sp IGBP1_HUMAN 33.531 337 211 5 20 355 15 339 3.04E-55 187 IGBP1_HUMAN reviewed Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16) IGBP1 IBP1 Homo sapiens (Human) 339 B cell activation [GO:0042113]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of protein dephosphorylation [GO:0035308]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of microtubule-based movement [GO:0060632]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165] GO:0000122; GO:0005737; GO:0005829; GO:0005874; GO:0007165; GO:0008601; GO:0032873; GO:0034612; GO:0035306; GO:0035308; GO:0042113; GO:0043154; GO:0045944; GO:0051721; GO:0060632; GO:0070555; GO:2001234 0 0 0 PF04177; Q008S8 CHOYP_LOC100369302.1.3 m.6808 sp ECT2L_HUMAN 45.609 353 187 3 779 1131 556 903 3.04E-91 316 ECT2L_HUMAN reviewed Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH) ECT2L C6orf91 LFDH Homo sapiens (Human) 904 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF14252;PF12937;PF00621; Q0VCA9 CHOYP_ISCW_ISCW011849.1.2 m.7521 sp TMED6_BOVIN 30.5 200 133 3 52 246 41 239 3.04E-21 92 TMED6_BOVIN reviewed Transmembrane emp24 domain-containing protein 6 (p24 family protein gamma-5) (p24gamma5) TMED6 Bos taurus (Bovine) 240 transport [GO:0006810] GO:0005789; GO:0006810; GO:0016021 0 0 0 PF01105; Q14624 CHOYP_LOC100692402.2.2 m.49856 sp ITIH4_HUMAN 36.661 641 346 13 35 659 35 631 3.04E-124 401 ITIH4_HUMAN reviewed Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) 930 acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; platelet degranulation [GO:0002576]; response to cytokine [GO:0034097] GO:0002576; GO:0004866; GO:0004867; GO:0005576; GO:0005886; GO:0006953; GO:0030212; GO:0031089; GO:0034097; GO:0070062; GO:0072562 0 0 0 PF06668;PF08487;PF00092; Q17RS7 CHOYP_GEN1.1.1 m.17676 sp GEN_HUMAN 43.992 491 205 8 1 428 1 484 3.04E-124 402 GEN_HUMAN reviewed Flap endonuclease GEN homolog 1 (EC 3.1.-.-) GEN1 Homo sapiens (Human) 908 double-strand break repair via homologous recombination [GO:0000724]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; resolution of mitotic recombination intermediates [GO:0071140]; resolution of recombination intermediates [GO:0071139] GO:0000724; GO:0003677; GO:0004520; GO:0005654; GO:0005813; GO:0008821; GO:0010824; GO:0046872; GO:0070062; GO:0071139; GO:0071140; GO:0090267 0 0 0 PF00867;PF00752; Q4R7Y5 CHOYP_DNJ6A.1.1 m.37366 sp DNJB6_MACFA 55.556 72 31 1 54 125 164 234 3.04E-15 72.4 DNJB6_MACFA reviewed DnaJ homolog subfamily B member 6 DNAJB6 QtsA-14076 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 241 0 GO:0005634; GO:0030018; GO:0048471 0 0 cd06257; PF00226; Q53G44 CHOYP_BRAFLDRAFT_91636.1.11 m.28449 sp IF44L_HUMAN 40.678 295 164 5 198 488 146 433 3.04E-60 207 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5ZM41 CHOYP_TEX10.3.3 m.52274 sp TEX10_CHICK 28.307 703 438 17 1 647 59 751 3.04E-66 238 TEX10_CHICK reviewed Testis-expressed sequence 10 protein homolog TEX10 RCJMB04_3d16 Gallus gallus (Chicken) 927 maturation of LSU-rRNA [GO:0000470]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000470; GO:0003682; GO:0005730; GO:0016021; GO:0030174; GO:0030687; GO:0031965; GO:0071339; GO:0097344 0 0 0 PF12333; Q63598 CHOYP_FIM.1.1 m.37220 sp PLST_RAT 57.447 470 181 9 72 527 165 629 3.04E-179 521 PLST_RAT reviewed Plastin-3 (T-plastin) Pls3 Rattus norvegicus (Rat) 630 auditory receptor cell differentiation [GO:0042491] GO:0005509; GO:0005737; GO:0032420; GO:0042491 0 0 0 PF00307;PF13499; Q66KC4 CHOYP_LOC100376464.1.1 m.29874 sp HSDL2_XENTR 36.162 271 164 6 5 271 14 279 3.04E-47 166 HSDL2_XENTR reviewed Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) hsdl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 417 0 GO:0005777; GO:0016491 0 0 0 PF00106;PF02036; Q6DIB5 CHOYP_MEG10.59.91 m.48287 sp MEG10_MOUSE 28.222 450 249 22 1 411 510 924 3.04E-24 108 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6PAF4 CHOYP_LOC100373071.1.2 m.40702 sp NSE1_XENLA 40.167 239 134 3 3 241 4 233 3.04E-60 197 NSE1_XENLA reviewed Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 6.3.2.-) nsmce1 Xenopus laevis (African clawed frog) 270 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of response to DNA damage stimulus [GO:2001022] GO:0000781; GO:0004842; GO:0005634; GO:0006281; GO:0006310; GO:0016874; GO:0030915; GO:0046872; GO:2001022 0 0 0 PF07574;PF08746; Q6PFY8 CHOYP_LOC100369333.24.32 m.48906 sp TRI45_MOUSE 25.837 209 136 8 1 196 118 320 3.04E-08 59.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q80T91 CHOYP_MEG10.72.91 m.55479 sp MEG11_MOUSE 37.188 320 180 14 164 481 352 652 3.04E-37 149 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8JHV9 CHOYP_TIAP2.7.13 m.51386 sp BIR7A_XENLA 29.054 444 235 11 481 923 36 400 3.04E-50 186 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8N6D5 CHOYP_LOC755521.22.28 m.54144 sp ANR29_HUMAN 35.909 220 140 1 15 234 49 267 3.04E-39 140 ANR29_HUMAN reviewed Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) 301 0 0 0 0 0 PF00023;PF12796; Q8TAD8 CHOYP_SNIP1.1.1 m.16448 sp SNIP1_HUMAN 52.648 321 130 9 81 384 65 380 3.04E-93 288 SNIP1_HUMAN reviewed Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) SNIP1 Homo sapiens (Human) 396 "I-kappaB kinase/NF-kappaB signaling [GO:0007249]; positive regulation of protein targeting to mitochondrion [GO:1903955]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005654; GO:0005737; GO:0006355; GO:0007249; GO:0035196; GO:0044822; GO:1903955 0 0 0 PF00498; Q8VD46 CHOYP_NEMVEDRAFT_V1G199674.1.1 m.11040 sp ASZ1_MOUSE 29.73 481 317 10 52 530 8 469 3.04E-53 191 ASZ1_MOUSE reviewed "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" Asz1 Gasz Mus musculus (Mouse) 475 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; male meiosis [GO:0007140]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0004871; GO:0005737; GO:0005829; GO:0007140; GO:0007275; GO:0007281; GO:0007283; GO:0031047; GO:0034587; GO:0043046; GO:0071546 0 0 0 PF12796;PF07647; Q90610 CHOYP_PTPRS.1.1 m.6451 sp NEO1_CHICK 30.45 289 191 5 469 751 526 810 3.04E-27 123 NEO1_CHICK reviewed Neogenin (Fragment) 0 Gallus gallus (Chicken) 1443 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; iron ion homeostasis [GO:0055072]; positive regulation of BMP signaling pathway [GO:0030513] GO:0004872; GO:0005887; GO:0007155; GO:0007411; GO:0030513; GO:0055072 0 0 0 PF00041;PF07679;PF13895;PF06583; Q96MM6 CHOYP_HSPA12A.22.27 m.57413 sp HS12B_HUMAN 32.566 304 188 7 1 293 363 660 3.04E-46 168 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96MY1 CHOYP_NOL4.1.1 m.56298 sp NOL4L_HUMAN 45.679 324 90 11 334 633 175 436 3.04E-65 224 NOL4L_HUMAN reviewed Nucleolar protein 4-like NOL4L C20orf112 C20orf113 Homo sapiens (Human) 436 0 GO:0005654; GO:0005737 0 0 0 0 Q99M80 CHOYP_LOC101384981.1.1 m.53468 sp PTPRT_MOUSE 32.892 529 298 13 340 821 759 1277 3.04E-65 241 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BRZ2 CHOYP_BRAFLDRAFT_70065.1.1 m.38238 sp TRI56_HUMAN 27.027 148 85 5 14 149 18 154 3.04E-08 55.5 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9EPS3 CHOYP_LOC100370244.4.4 m.57640 sp GLCE_MOUSE 42.605 622 314 11 3 591 7 618 3.04E-174 510 GLCE_MOUSE reviewed D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin sulfate C5-epimerase) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) Glce Mus musculus (Mouse) 618 glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] GO:0000139; GO:0005794; GO:0006024; GO:0015012; GO:0016021; GO:0016857; GO:0030210; GO:0047464; GO:0050379 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis. 0 0 PF06662; Q9VCA8 CHOYP_LOC764549.1.3 m.25819 sp ANKHM_DROME 30.035 283 185 8 1 275 757 1034 3.04E-25 110 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9Z0V8 CHOYP_ARF2.2.3 m.48908 sp TI17A_MOUSE 50.602 166 75 2 1 164 1 161 3.04E-53 170 TI17A_MOUSE reviewed Mitochondrial import inner membrane translocase subunit Tim17-A (Inner membrane preprotein translocase Tim17a) Timm17a Tim17a Mus musculus (Mouse) 171 protein import into mitochondrial matrix [GO:0030150] GO:0005654; GO:0005739; GO:0005743; GO:0005744; GO:0015450; GO:0030150; GO:0031305 0 0 0 PF02466; A2ASS6 CHOYP_TTN.2.9 m.17508 sp TITIN_MOUSE 26.287 544 336 20 119 647 6966 7459 3.05E-29 129 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A2T737 CHOYP_EHF.1.1 m.61007 sp EHF_PANTR 34.752 141 81 3 166 303 167 299 3.05E-17 84 EHF_PANTR reviewed ETS homologous factor (ETS domain-containing transcription factor) EHF Pan troglodytes (Chimpanzee) 300 cell differentiation [GO:0030154]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000978; GO:0000981; GO:0001077; GO:0005634; GO:0005654; GO:0005794; GO:0006357; GO:0030154; GO:0030855; GO:0050673 0 0 0 PF00178;PF02198; B2GV05 CHOYP_RBM10.1.2 m.55985 sp RBM5_RAT 41.781 146 70 5 124 268 62 193 3.05E-19 90.9 RBM5_RAT reviewed RNA-binding protein 5 (RNA-binding motif protein 5) Rbm5 Rattus norvegicus (Rat) 815 "apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal complex assembly [GO:0000245]" GO:0000166; GO:0000245; GO:0000381; GO:0003729; GO:0005634; GO:0005654; GO:0005681; GO:0006915; GO:0008270; GO:0043065 0 0 0 PF01585;PF00076;PF00641; D2GXS7 CHOYP_BRAFLDRAFT_79377.2.30 m.8480 sp TRIM2_AILME 23.776 143 106 2 13 153 602 743 3.05E-07 55.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O02467 CHOYP_LOC100697862.1.1 m.27738 sp ASPG_SPOFR 55 320 140 3 34 351 3 320 3.05E-119 350 ASPG_SPOFR reviewed N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] (Fragment) 0 Spodoptera frugiperda (Fall armyworm) 320 0 GO:0003948; GO:0005764; GO:0008233 0 0 0 PF01112; O02824 CHOYP_LOC100554316.1.1 m.36041 sp ADA1A_RABIT 46.825 252 127 4 1 249 114 361 3.05E-74 239 ADA1A_RABIT reviewed Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) ADRA1A ADRA1C Oryctolagus cuniculus (Rabbit) 466 positive regulation of MAPK cascade [GO:0043410]; regulation of cardiac muscle contraction [GO:0055117]; regulation of vasoconstriction [GO:0019229] GO:0004937; GO:0005634; GO:0005886; GO:0016021; GO:0019229; GO:0031965; GO:0043410; GO:0046982; GO:0055117 0 0 0 PF00001; O14513 CHOYP_LOC100372012.1.1 m.36569 sp NCKP5_HUMAN 46.988 249 119 5 25 269 30 269 3.05E-47 191 NCKP5_HUMAN reviewed Nck-associated protein 5 (NAP-5) (Peripheral clock protein) NCKAP5 ERIH NAP5 Homo sapiens (Human) 1909 0 0 0 0 0 PF15246; O55135 CHOYP_IF6.1.1 m.22685 sp IF6_MOUSE 84.016 244 39 0 1 244 1 244 3.05E-151 424 IF6_MOUSE reviewed Eukaryotic translation initiation factor 6 (eIF-6) (B4 integrin interactor) (CAB) (p27(BBP)) Eif6 Itgb4bp Mus musculus (Mouse) 245 assembly of large subunit precursor of preribosome [GO:1902626]; gene silencing by miRNA [GO:0035195]; maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470]; mature ribosome assembly [GO:0042256]; miRNA mediated inhibition of translation [GO:0035278]; positive regulation of translation [GO:0045727]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to insulin [GO:0032868]; ribosomal subunit export from nucleus [GO:0000054] GO:0000054; GO:0000460; GO:0000470; GO:0003743; GO:0005634; GO:0005638; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005882; GO:0006110; GO:0030687; GO:0032868; GO:0035195; GO:0035278; GO:0042256; GO:0042304; GO:0043022; GO:0043023; GO:0045652; GO:0045727; GO:0070062; GO:1902626; GO:2000377 0 0 cd00527; PF01912; O70277 CHOYP_BRAFLDRAFT_67264.3.6 m.33010 sp TRIM3_RAT 26.984 126 86 3 195 318 622 743 3.05E-07 56.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_TRIM2.15.59 m.28135 sp TRIM3_HUMAN 23.827 277 172 12 18 273 486 744 3.05E-08 57.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0C6B8 CHOYP_LOC100367084.20.22 m.60073 sp SVEP1_RAT 24.854 684 413 22 116 712 436 1105 3.05E-30 134 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P41041 CHOYP_CALM.9.50 m.21996 sp CALM_PNECA 72.222 144 40 0 10 153 5 148 3.05E-70 213 CALM_PNECA reviewed Calmodulin (CaM) 0 Pneumocystis carinii 151 0 GO:0005509 0 0 0 PF13499; P46425 CHOYP_BRAFLDRAFT_131621.1.1 m.56341 sp GSTP2_MOUSE 27.801 241 129 7 1 229 1 208 3.05E-21 90.9 GSTP2_MOUSE reviewed Glutathione S-transferase P 2 (Gst P2) (EC 2.5.1.18) (GST YF-YF) (GST class-pi) (GST-piA) Gstp2 Gstpia Mus musculus (Mouse) 210 glutathione metabolic process [GO:0006749] GO:0004364; GO:0005615; GO:0005622; GO:0005737; GO:0005739; GO:0006749; GO:0031982; GO:0035730; GO:0035731; GO:0070062; GO:0097057 0 0 0 PF14497;PF02798; P55210 CHOYP_XCASPASE-7.1.4 m.26576 sp CASP7_HUMAN 42.23 296 153 4 7 294 17 302 3.05E-74 233 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 Q0E908 CHOYP_LOC100875804.1.1 m.48412 sp HIL_DROME 30.277 469 288 12 101 549 335 784 3.05E-52 199 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q14657 CHOYP_LOC100536597.1.1 m.52329 sp LAGE3_HUMAN 47.368 76 40 0 36 111 65 140 3.05E-20 82.8 LAGE3_HUMAN reviewed EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) LAGE3 DXS9879E ESO3 ITBA2 Homo sapiens (Human) 143 tRNA processing [GO:0008033] GO:0005634; GO:0008033 0 0 0 PF09341; Q1HG43 CHOYP_LOC576350.1.2 m.22910 sp DOXA1_HUMAN 34.967 306 180 6 31 331 10 301 3.05E-49 174 DOXA1_HUMAN reviewed Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) 343 hydrogen peroxide metabolic process [GO:0042743]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609] GO:0005789; GO:0005886; GO:0015031; GO:0016020; GO:0016021; GO:0042743; GO:0045666; GO:0050727; GO:2000379; GO:2000609 0 0 0 PF10204; Q5E936 CHOYP_TXD12.1.1 m.18602 sp TXD12_BOVIN 49.419 172 81 2 1 168 3 172 3.05E-49 159 TXD12_BOVIN reviewed Thioredoxin domain-containing protein 12 (EC 1.8.4.2) TXNDC12 Bos taurus (Bovine) 172 cell redox homeostasis [GO:0045454]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236] GO:0005788; GO:0015037; GO:0019153; GO:0045454; GO:1902236 0 0 0 0 Q5M9N0 CHOYP_CCDC158.1.1 m.42581 sp CD158_HUMAN 25.82 488 313 8 2 465 651 1113 3.05E-30 128 CD158_HUMAN reviewed Coiled-coil domain-containing protein 158 CCDC158 Homo sapiens (Human) 1113 0 0 0 0 0 PF15921; Q5U3U7 CHOYP_BRAFLDRAFT_232648.1.1 m.25539 sp NLS1A_DANRE 43.386 189 102 3 1 184 341 529 3.05E-42 152 NLS1A_DANRE reviewed Sodium-dependent lysophosphatidylcholine symporter 1-A (NLS1-A) (Sodium-dependent LPC symporter 1-A) (Major facilitator superfamily domain-containing protein 2A-A) mfsd2aa mfsd2a nls1a zgc:101615 Danio rerio (Zebrafish) (Brachydanio rerio) 532 establishment of blood-brain barrier [GO:0060856]; fatty acid transport [GO:0015908]; lipid transport across blood brain barrier [GO:1990379]; lysophospholipid transport [GO:0051977]; maintenance of blood-brain barrier [GO:0035633]; transcytosis [GO:0045056] GO:0005548; GO:0005789; GO:0005887; GO:0015293; GO:0015908; GO:0035633; GO:0045056; GO:0051977; GO:0060856; GO:1990379 0 0 0 0 Q6DHR8 CHOYP_LOC100375768.1.1 m.25334 sp NGBR_DANRE 37.037 216 130 3 48 261 63 274 3.05E-45 156 NGBR_DANRE reviewed "Dehydrodolichyl diphosphate synthase complex subunit nus1 (EC 2.5.1.87) (Di-trans,poly-cis-decaprenylcistransferase) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog)" nus1 ngbr si:ch211-102b16.1 zgc:92136 Danio rerio (Zebrafish) (Brachydanio rerio) 274 protein glycosylation [GO:0006486]; sprouting angiogenesis [GO:0002040] GO:0002040; GO:0005789; GO:0006486; GO:0016021; GO:0016765 PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}. 0 0 PF01255; Q6KAU4 CHOYP_LOC100077534.1.1 m.23889 sp MB12B_MOUSE 35.106 282 148 8 7 276 47 305 3.05E-40 144 MB12B_MOUSE reviewed Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) Mvb12b Fam125b Mus musculus (Mouse) 317 positive regulation of viral process [GO:0048524]; protein transport [GO:0015031]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; virus maturation [GO:0019075] GO:0000813; GO:0005634; GO:0005769; GO:0005770; GO:0005829; GO:0005886; GO:0008289; GO:0015031; GO:0019075; GO:0031902; GO:0031982; GO:0042058; GO:0048524; GO:0070062 0 0 0 PF10240; Q6XZB0 CHOYP_PHUM_PHUM046940.1.1 m.37002 sp LIPI_HUMAN 42.739 241 127 7 445 677 40 277 3.05E-46 174 LIPI_HUMAN reviewed Lipase member I (LIPI) (EC 3.1.1.-) (Cancer/testis antigen 17) (CT17) (LPD lipase) (Membrane-associated phosphatidic acid-selective phospholipase A1-beta) (mPA-PLA1 beta) LIPI LPDL PRED5 Homo sapiens (Human) 460 lipid catabolic process [GO:0016042]; lipid digestion [GO:0044241] GO:0004620; GO:0005576; GO:0005615; GO:0005886; GO:0008201; GO:0016042; GO:0044241; GO:0052689 0 0 0 PF00151; Q6ZNB7 CHOYP_ALKMO.1.1 m.30183 sp ALKMO_HUMAN 54.374 423 186 2 19 440 15 431 3.05E-159 460 ALKMO_HUMAN reviewed Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195) AGMO TMEM195 Homo sapiens (Human) 445 ether lipid metabolic process [GO:0046485]; fatty acid biosynthetic process [GO:0006633]; membrane lipid metabolic process [GO:0006643]; triglyceride biosynthetic process [GO:0019432] GO:0005506; GO:0005783; GO:0005789; GO:0006633; GO:0006643; GO:0016021; GO:0019432; GO:0046485; GO:0050479 0 0 0 PF04116; Q8HYW0 CHOYP_FA13A.2.2 m.34224 sp FA13A_BOVIN 34.722 504 246 17 571 1036 234 692 3.05E-61 226 FA13A_BOVIN reviewed Protein FAM13A (Protein Precm1) FAM13A FAM13A1 PRECM1 Bos taurus (Bovine) 697 0 0 0 0 0 0 Q8WV16 CHOYP_DCAF4.1.1 m.3674 sp DCAF4_HUMAN 26.86 484 326 15 26 491 19 492 3.05E-37 146 DCAF4_HUMAN reviewed DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) DCAF4 WDR21 WDR21A Homo sapiens (Human) 495 protein ubiquitination [GO:0016567] GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q96KG7 CHOYP_LOC100707338.1.5 m.2633 sp MEG10_HUMAN 37.917 240 121 11 197 424 128 351 3.05E-27 119 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q99PT3 CHOYP_LOC101061686.1.1 m.59067 sp IN80B_MOUSE 36.364 275 139 7 100 338 84 358 3.05E-30 121 IN80B_MOUSE reviewed INO80 complex subunit B (High mobility group AT-hook 1-like 4) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) Ino80b Hmga1l4 Papa1 Znhit4 Mus musculus (Mouse) 375 "chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006281; GO:0006310; GO:0006338; GO:0006351; GO:0006355; GO:0031011; GO:0046872 0 0 0 PF04795;PF04438; Q9DFQ7 CHOYP_BRAFLDRAFT_273508.2.4 m.10827 sp RL24_GILMI 69.492 118 29 2 2 115 43 157 3.05E-42 139 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9ESN6 CHOYP_BRAFLDRAFT_88223.3.22 m.20538 sp TRIM2_MOUSE 28.409 176 113 6 301 471 536 703 3.05E-10 66.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC592222.1.2 m.32718 sp TRIM2_MOUSE 25.309 162 114 4 118 274 547 706 3.05E-08 58.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM3.51.58 m.53329 sp TRIM2_MOUSE 29.767 215 136 8 92 299 536 742 3.05E-14 76.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAR2 CHOYP_LOC100702950.4.4 m.39315 sp AGRL3_HUMAN 26.806 623 382 24 34 615 566 1155 3.05E-49 189 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9IA76 CHOYP_RL31.2.2 m.29424 sp RL31_PAROL 72.131 122 34 0 1 122 1 122 3.05E-62 189 RL31_PAROL reviewed 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) 124 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00463; PF01198; Q9JM83 CHOYP_LOC764291.1.1 m.29907 sp CALM4_MOUSE 29.688 64 45 0 63 126 85 148 3.05E-06 48.1 CALM4_MOUSE reviewed Calmodulin-4 (Calcium-binding protein Dd112) Calm4 Dd112 Mus musculus (Mouse) 148 0 GO:0005509; GO:0070062 0 0 0 PF13499; Q9Y493 CHOYP_NEMVEDRAFT_V1G214844.24.34 m.54633 sp ZAN_HUMAN 35.156 256 165 1 1624 1878 535 790 3.05E-19 100 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A2AX52 CHOYP_COSA1.1.1 m.40255 sp CO6A4_MOUSE 26.733 202 130 8 25 219 224 414 3.06E-06 54.7 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; E1BD59 CHOYP_NEMVEDRAFT_V1G193373.2.2 m.46579 sp TRI56_BOVIN 23.427 286 176 8 11 275 14 277 3.06E-12 70.1 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O00370 CHOYP_RTJK.2.3 m.35835 sp LORF2_HUMAN 27.957 186 120 4 166 344 450 628 3.06E-13 74.3 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O43174 CHOYP_CP26A.1.1 m.9958 sp CP26A_HUMAN 40.162 493 267 9 19 493 5 487 3.06E-117 357 CP26A_HUMAN reviewed Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) CYP26A1 CYP26 P450RAI1 Homo sapiens (Human) 497 negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805] GO:0001972; GO:0005506; GO:0005789; GO:0006766; GO:0006805; GO:0008401; GO:0016709; GO:0019825; GO:0020037; GO:0031090; GO:0034653; GO:0042573; GO:0048387 0 0 0 PF00067; O94759 CHOYP_LOC100704039.1.1 m.21695 sp TRPM2_HUMAN 25.911 494 287 13 528 969 620 1086 3.06E-31 136 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; P15291 CHOYP_LOC100160869.1.2 m.44726 sp B4GT1_HUMAN 54.335 173 76 1 77 246 222 394 3.06E-60 198 B4GT1_HUMAN reviewed "Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1] [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthase); Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)]" B4GALT1 GGTB2 Homo sapiens (Human) 398 acute inflammatory response [GO:0002526]; angiogenesis involved in wound healing [GO:0060055]; binding of sperm to zona pellucida [GO:0007339]; branching morphogenesis of an epithelial tube [GO:0048754]; cell adhesion [GO:0007155]; development of secondary sexual characteristics [GO:0045136]; epithelial cell development [GO:0002064]; extracellular matrix organization [GO:0030198]; galactose metabolic process [GO:0006012]; keratan sulfate biosynthetic process [GO:0018146]; lactose biosynthetic process [GO:0005989]; leukocyte migration [GO:0050900]; mammary gland development [GO:0030879]; negative regulation of cell proliferation [GO:0008285]; oligosaccharide biosynthetic process [GO:0009312]; penetration of zona pellucida [GO:0007341]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; protein N-linked glycosylation [GO:0006487]; regulation of acrosome reaction [GO:0060046]; regulation of cellular component movement [GO:0051270] GO:0000138; GO:0000139; GO:0002064; GO:0002526; GO:0003831; GO:0003945; GO:0004461; GO:0005615; GO:0005794; GO:0005886; GO:0005989; GO:0006012; GO:0006487; GO:0007155; GO:0007339; GO:0007341; GO:0008285; GO:0008378; GO:0009312; GO:0009897; GO:0016020; GO:0016021; GO:0016323; GO:0018146; GO:0030057; GO:0030112; GO:0030145; GO:0030175; GO:0030198; GO:0030879; GO:0031526; GO:0032580; GO:0035250; GO:0042803; GO:0043014; GO:0045136; GO:0048487; GO:0048754; GO:0050900; GO:0051270; GO:0060046; GO:0060054; GO:0060055; GO:0060058; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02709;PF13733; P23414 CHOYP_AGAP_AGAP002972.1.1 m.62585 sp ACH1_SCHGR 29.032 310 199 4 28 319 27 333 3.06E-40 153 ACH1_SCHGR reviewed Acetylcholine receptor subunit alpha-L1 0 Schistocerca gregaria (Desert locust) 557 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; P34641 CHOYP_ISCW_ISCW010958.1.1 m.67057 sp CED11_CAEEL 41.818 55 29 1 14 68 595 646 3.06E-08 55.5 CED11_CAEEL reviewed Protein ced-11 (Cell death protein 11) ced-11 ZK512.3 Caenorhabditis elegans 1418 apoptotic process [GO:0006915] GO:0006915; GO:0016021 0 0 0 0 P58308 CHOYP_LOC762961.1.5 m.36558 sp OX2R_MOUSE 22.581 372 220 10 33 392 62 377 3.06E-11 68.6 OX2R_MOUSE reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P70227 CHOYP_LOC100375107.2.4 m.15902 sp ITPR3_MOUSE 21.692 1489 921 44 1 1306 4 1430 3.06E-66 254 ITPR3_MOUSE reviewed "Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)" Itpr3 Mus musculus (Mouse) 2670 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cellular response to cAMP [GO:0071320]; G-protein coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917] GO:0000822; GO:0005220; GO:0005509; GO:0005634; GO:0005640; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005829; GO:0005886; GO:0005887; GO:0006816; GO:0007186; GO:0007613; GO:0015278; GO:0016020; GO:0030425; GO:0035091; GO:0043025; GO:0043209; GO:0043235; GO:0043533; GO:0048471; GO:0050913; GO:0050916; GO:0050917; GO:0051260; GO:0051291; GO:0051592; GO:0060291; GO:0060402; GO:0070679; GO:0071320 0 0 0 PF08709;PF00520;PF02815;PF08454;PF01365; P91926 CHOYP_LOC100366818.1.1 m.41118 sp AP2A_DROME 81.579 114 21 0 1 114 44 157 3.06E-60 202 AP2A_DROME reviewed AP-2 complex subunit alpha (Alpha-adaptin) AP-2alpha CG4260 Drosophila melanogaster (Fruit fly) 940 asymmetric cell division [GO:0008356]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; neurogenesis [GO:0022008]; neurotransmitter secretion [GO:0007269]; ovarian follicle cell development [GO:0030707]; positive regulation of endocytosis [GO:0045807]; protein localization [GO:0008104]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; sensory perception of pain [GO:0019233]; synaptic vesicle coating [GO:0016183]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle transport [GO:0048489]; vesicle coating [GO:0006901] GO:0005886; GO:0005905; GO:0006886; GO:0006897; GO:0006901; GO:0007269; GO:0008021; GO:0008104; GO:0008356; GO:0008565; GO:0015031; GO:0016183; GO:0019233; GO:0022008; GO:0030100; GO:0030122; GO:0030135; GO:0030707; GO:0045807; GO:0048488; GO:0048489 0 0 0 PF01602;PF02296;PF02883; Q0E908 CHOYP_BRAFLDRAFT_92367.4.4 m.59498 sp HIL_DROME 21.81 431 262 16 330 713 328 730 3.06E-14 81.6 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q0E908 CHOYP_LOC100901500.2.3 m.52593 sp HIL_DROME 27.862 463 284 13 2 431 369 814 3.06E-42 167 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q12802 CHOYP_AKP13.3.5 m.29354 sp AKP13_HUMAN 31.926 758 422 26 1013 1726 1971 2678 3.06E-85 316 AKP13_HUMAN reviewed A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) 2813 adrenergic receptor signaling pathway [GO:0071875]; adrenergic receptor signaling pathway involved in heart process [GO:0086023]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; nuclear export [GO:0051168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cardiac muscle hypertrophy [GO:0010611]; regulation of glucocorticoid mediated signaling pathway [GO:1900169]; regulation of protein kinase activity [GO:0045859]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004691; GO:0004871; GO:0005078; GO:0005085; GO:0005089; GO:0005634; GO:0005737; GO:0005829; GO:0005938; GO:0007186; GO:0007507; GO:0010611; GO:0016020; GO:0017048; GO:0032947; GO:0035025; GO:0035556; GO:0043065; GO:0043123; GO:0045859; GO:0046872; GO:0048471; GO:0051018; GO:0051056; GO:0051168; GO:0055007; GO:0060297; GO:0060348; GO:0071875; GO:0086023; GO:1900169 0 0 0 PF00169;PF00621;PF10522; Q20363 CHOYP_TSP_09282.1.1 m.18814 sp SIP1_CAEEL 31.169 77 53 0 45 121 49 125 3.06E-08 52.4 SIP1_CAEEL reviewed Stress-induced protein 1 sip-1 F43D9.4 Caenorhabditis elegans 159 determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; multicellular organismal protein metabolic process [GO:0044268]; response to heat [GO:0009408] GO:0005829; GO:0008340; GO:0009408; GO:0009792; GO:0044268; GO:0051082 0 0 0 PF00011; Q26619 CHOYP_KAPR.3.3 m.59092 sp KAPR_STRPU 57.682 371 144 5 1 366 1 363 3.06E-145 418 KAPR_STRPU reviewed cAMP-dependent protein kinase type II regulatory subunit 0 Strongylocentrotus purpuratus (Purple sea urchin) 369 0 GO:0005952; GO:0008603; GO:0030552 0 0 0 PF00027;PF02197; Q38871 CHOYP_LOC100371068.1.1 m.30925 sp CDPK5_ARATH 40.909 66 39 0 122 187 405 470 3.06E-07 55.5 CDPK5_ARATH reviewed Calcium-dependent protein kinase 5 (EC 2.7.11.1) (Calmodulin-domain protein kinase CDPK isoform 5) CPK5 At4g35310 F23E12.130 Arabidopsis thaliana (Mouse-ear cress) 556 abscisic acid-activated signaling pathway [GO:0009738]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; response to abscisic acid [GO:0009737] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005829; GO:0005886; GO:0009737; GO:0009738; GO:0009931; GO:0016020; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; Q5E9P6 CHOYP_LOC100699837.1.1 m.54956 sp BSCL2_BOVIN 37.604 359 192 8 12 350 12 358 3.06E-77 245 BSCL2_BOVIN reviewed Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog) BSCL2 Bos taurus (Bovine) 394 fat cell differentiation [GO:0045444]; lipid catabolic process [GO:0016042]; lipid particle organization [GO:0034389]; lipid storage [GO:0019915]; negative regulation of lipid catabolic process [GO:0050995] GO:0016042; GO:0019915; GO:0030176; GO:0034389; GO:0045444; GO:0050995 0 0 0 PF06775; Q5EAR5 CHOYP_BRAFLDRAFT_265162.1.3 m.58969 sp TRPT1_DANRE 50.732 205 94 4 242 442 23 224 3.06E-62 212 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q5K651 CHOYP_LOC100368821.2.7 m.37016 sp SAMD9_HUMAN 25.242 931 593 33 1 880 305 1183 3.06E-58 223 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q642H7 CHOYP_PHUM_PHUM060390.1.1 m.12993 sp RIC8A_DANRE 40.183 545 285 11 2 522 3 530 3.06E-123 375 RIC8A_DANRE reviewed Synembryn-A (Protein Ric-8A) ric8a zgc:92294 Danio rerio (Zebrafish) (Brachydanio rerio) 548 G-protein coupled receptor signaling pathway [GO:0007186] GO:0001965; GO:0005085; GO:0005096; GO:0005737; GO:0005886; GO:0007186 0 0 0 PF10165; Q6DEB4 CHOYP_UBQL4.1.1 m.37429 sp AR19A_XENLA 55.556 90 35 3 32 120 31 116 3.06E-20 82.4 AR19A_XENLA reviewed cAMP-regulated phosphoprotein 19-A (ARPP-19-A) arpp19-a arpp19 Xenopus laevis (African clawed frog) 117 cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067] GO:0000086; GO:0004864; GO:0005654; GO:0005737; GO:0007067; GO:0008601; GO:0019212; GO:0019901; GO:0051301; GO:0051721 0 0 0 PF04667; Q6P8Y1 CHOYP_CAPSLB.1.1 m.58887 sp CAPSL_MOUSE 59.135 208 85 0 122 329 1 208 3.06E-92 276 CAPSL_MOUSE reviewed Calcyphosin-like protein Capsl Mus musculus (Mouse) 208 0 GO:0005509; GO:0005737 0 0 0 PF13499; Q6TCH7 CHOYP_BRAFLDRAFT_62482.1.1 m.38826 sp PAQR3_HUMAN 48.029 279 144 1 48 325 26 304 3.06E-92 280 PAQR3_HUMAN reviewed Progestin and adipoQ receptor family member 3 (Progestin and adipoQ receptor family member III) (Raf kinase trapping to Golgi) (RKTG) PAQR3 Homo sapiens (Human) 311 MAPK cascade [GO:0000165]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuron projection development [GO:0010977]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein phosphorylation [GO:0001933]; protein localization to Golgi apparatus [GO:0034067] GO:0000139; GO:0000165; GO:0001933; GO:0004872; GO:0005794; GO:0010977; GO:0016021; GO:0033137; GO:0034067; GO:0043407 0 0 0 PF03006; Q80YX1 CHOYP_LOC100374909.2.2 m.57749 sp TENA_MOUSE 43.119 109 57 3 1 109 1994 2097 3.06E-23 96.3 TENA_MOUSE reviewed Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) 2110 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] GO:0001649; GO:0001968; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; Q8BMQ3 CHOYP_LOC100378553.1.1 m.7444 sp BNC2_MOUSE 63.978 186 65 2 5 190 137 320 3.06E-73 265 BNC2_MOUSE reviewed Zinc finger protein basonuclin-2 Bnc2 Mus musculus (Mouse) 1127 "endochondral bone growth [GO:0003416]; mesenchyme development [GO:0060485]; palate development [GO:0060021]; regulation of transcription, DNA-templated [GO:0006355]; tongue development [GO:0043586]; transcription, DNA-templated [GO:0006351]" GO:0003416; GO:0003677; GO:0005634; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0043586; GO:0046872; GO:0060021; GO:0060485 0 0 0 0 Q8ITC3 CHOYP_RS19.2.12 m.5478 sp RS19_ARGIR 74.016 127 32 1 40 166 1 126 3.06E-67 204 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8N6G6 CHOYP_LOC100169530.1.1 m.51833 sp ATL1_HUMAN 29.622 476 286 9 183 613 301 772 3.06E-56 209 ATL1_HUMAN reviewed ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) ADAMTSL1 ADAMTSR1 C9orf94 UNQ528/PRO1071 Homo sapiens (Human) 1762 protein O-linked fucosylation [GO:0036066] GO:0005578; GO:0005788; GO:0008237; GO:0008270; GO:0036066 0 0 0 PF07679;PF08686;PF00090; Q8N7Z5 CHOYP_ANR31.1.1 m.61075 sp ANR31_HUMAN 40.385 104 62 0 49 152 1148 1251 3.06E-13 77.8 ANR31_HUMAN reviewed Putative ankyrin repeat domain-containing protein 31 ANKRD31 Homo sapiens (Human) 1873 0 0 0 0 0 PF00023;PF12796; Q91770 CHOYP_NOT.1.1 m.33646 sp NOT2_XENLA 72.84 81 20 1 151 229 128 208 3.06E-33 124 NOT2_XENLA reviewed Homeobox protein not2 (Xnot-2) (Xnot2) not2 Xenopus laevis (African clawed frog) 233 "negative regulation of transcription, DNA-templated [GO:0045892]; notochord formation [GO:0014028]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0014028; GO:0043565; GO:0045892 0 0 0 PF00046; Q963B6 CHOYP_LOC100204815.1.1 m.20718 sp RL10A_SPOFR 75.355 211 52 0 17 227 1 211 3.06E-107 310 RL10A_SPOFR reviewed 60S ribosomal protein L10a RpL10A Spodoptera frugiperda (Fall armyworm) 217 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015934 0 0 cd00403; PF00687; Q96RW7 CHOYP_LOC100210677.6.8 m.38968 sp HMCN1_HUMAN 47.661 342 179 0 604 945 4528 4869 3.06E-98 349 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96S53 CHOYP_LOC100114427.1.1 m.22897 sp TESK2_HUMAN 64.706 51 18 0 45 95 41 91 3.06E-14 70.9 TESK2_HUMAN reviewed Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) TESK2 Homo sapiens (Human) 571 actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] GO:0004672; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0007283; GO:0030036; GO:0046872; GO:0048041 0 0 0 PF07714; Q99NH0 CHOYP_AASI_0340.2.2 m.49744 sp ANR17_MOUSE 36.905 252 141 10 174 417 401 642 3.06E-27 118 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q99NH0 CHOYP_LOC753709.4.44 m.17072 sp ANR17_MOUSE 33.525 522 316 18 349 849 209 720 3.06E-55 211 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9DFQ7 CHOYP_RL24.6.9 m.43124 sp RL24_GILMI 68.103 116 30 2 2 113 43 155 3.06E-40 134 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9JLF6 CHOYP_NEMVEDRAFT_V1G97278.2.2 m.63646 sp TGM1_MOUSE 38.705 695 402 13 72 758 107 785 3.06E-152 467 TGM1_MOUSE reviewed Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) Tgm1 Mus musculus (Mouse) 815 keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; organ morphogenesis [GO:0009887]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838]; protein metabolic process [GO:0019538] GO:0003810; GO:0005913; GO:0009887; GO:0010838; GO:0018149; GO:0019538; GO:0030216; GO:0031224; GO:0031424; GO:0045787; GO:0046872; GO:0070062 0 0 0 PF00927;PF01841;PF00868; Q9QY93 CHOYP_ZGC_73273.1.1 m.18633 sp DCTP1_MOUSE 53.846 130 57 1 19 148 16 142 3.06E-45 149 DCTP1_MOUSE reviewed dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21-C6) (XTP3-transactivated gene A protein homolog) Dctpp1 Tdrg-TL1 Mus musculus (Mouse) 170 nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate catabolic process [GO:0009143]; protein homotetramerization [GO:0051289] GO:0000287; GO:0005829; GO:0009143; GO:0015949; GO:0016462; GO:0032556; GO:0042802; GO:0047429; GO:0047840; GO:0051289 0 0 cd11537; PF12643; Q9V576 CHOYP_DGRI_GH21309.1.1 m.48524 sp WUN_DROME 42.105 266 135 5 3 249 84 349 3.06E-71 228 WUN_DROME reviewed Putative phosphatidate phosphatase (EC 3.1.3.4) (Germ cell guidance factor) (Phosphatidic acid phosphatase type 2) (Protein wunen) wun CG8804 Drosophila melanogaster (Fruit fly) 379 defense response to Gram-negative bacterium [GO:0050829]; dephosphorylation [GO:0016311]; ectopic germ cell programmed cell death [GO:0035234]; embryonic pattern specification [GO:0009880]; germ cell migration [GO:0008354]; germ cell repulsion [GO:0035233]; negative regulation of innate immune response [GO:0045824]; open tracheal system development [GO:0007424]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; pole cell migration [GO:0007280]; septate junction assembly [GO:0019991]; signal transduction [GO:0007165] GO:0005887; GO:0005918; GO:0006644; GO:0007165; GO:0007280; GO:0007424; GO:0008195; GO:0008354; GO:0009880; GO:0016311; GO:0016791; GO:0019991; GO:0035233; GO:0035234; GO:0042577; GO:0042803; GO:0045177; GO:0045824; GO:0046839; GO:0050829 0 0 0 PF01569; Q9Y264 CHOYP_BRAFLDRAFT_125263.6.9 m.52537 sp ANGP4_HUMAN 37.299 311 173 10 66 362 198 500 3.06E-56 194 ANGP4_HUMAN reviewed Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) ANGPT4 ANG3 ANG4 Homo sapiens (Human) 503 angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] GO:0001525; GO:0005576; GO:0005615; GO:0007219; GO:0010595; GO:0016525; GO:0030297; GO:0030971; GO:0043066; GO:0043536; GO:0043537; GO:0045766; GO:0050731; GO:0050900; GO:0071456 0 0 0 PF00147; Q9Y493 CHOYP_BRAFLDRAFT_90332.2.4 m.5972 sp ZAN_HUMAN 36.742 264 108 4 276 518 570 795 3.06E-13 76.6 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; Q9Y5E5 CHOYP_contig_018406 m.21579 sp PCDB4_HUMAN 27.049 366 236 16 456 798 193 550 3.06E-18 93.6 PCDB4_HUMAN reviewed Protocadherin beta-4 (PCDH-beta-4) PCDHB4 Homo sapiens (Human) 795 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416] GO:0005509; GO:0005737; GO:0005886; GO:0005887; GO:0007155; GO:0007156; GO:0007268; GO:0007399; GO:0007416; GO:0016021; GO:0016339; GO:0045111 0 0 0 PF00028;PF08266;PF16492; F7H9X2 CHOYP_LOC100374981.6.16 m.32594 sp TRIM2_CALJA 23.134 268 184 7 334 590 488 744 3.07E-10 67 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_MEGF6.48.59 m.51016 sp MEGF6_HUMAN 35.871 867 461 33 154 958 597 1430 3.07E-104 360 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P16157 CHOYP_LOC755521.24.28 m.56886 sp ANK1_HUMAN 37.41 139 87 0 4 142 636 774 3.07E-24 100 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20825 CHOYP_contig_017900 m.20939 sp POL2_DROME 41.237 97 50 2 4 95 221 315 3.07E-16 77.4 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P38584 CHOYP_TTL.1.1 m.21690 sp TTL_BOVIN 53.699 365 163 5 1 364 1 360 3.07E-130 381 TTL_BOVIN reviewed Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25) TTL Bos taurus (Bovine) 377 cellular protein modification process [GO:0006464] GO:0004835; GO:0005524; GO:0006464 0 0 0 PF03133; P43935 CHOYP_LOC734029.1.2 m.26565 sp Y077_HAEIN 35.789 190 118 2 247 436 84 269 3.07E-29 119 Y077_HAEIN reviewed Uncharacterized protein HI_0077 HI_0077 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 288 0 0 0 0 0 PF04305; P49001 CHOYP_BMP4.2.2 m.35798 sp BMP2_RAT 46.053 380 171 10 41 418 46 393 3.07E-110 332 BMP2_RAT reviewed Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A) Bmp2 Bmp-2 Rattus norvegicus (Rat) 393 BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to mechanical stimulus [GO:0071260]; growth [GO:0040007]; mesenchymal cell differentiation [GO:0048762]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; ossification [GO:0001503]; ovulation cycle [GO:0042698]; positive regulation of neurogenesis [GO:0050769]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of MAPK cascade [GO:0043408]; response to mechanical stimulus [GO:0009612]; response to retinoic acid [GO:0032526]; SMAD protein signal transduction [GO:0060395] GO:0000122; GO:0001503; GO:0005102; GO:0005125; GO:0005160; GO:0005615; GO:0005737; GO:0008083; GO:0009612; GO:0010862; GO:0019904; GO:0030509; GO:0031988; GO:0032526; GO:0040007; GO:0042698; GO:0042803; GO:0042981; GO:0043234; GO:0043408; GO:0045944; GO:0048762; GO:0050769; GO:0051216; GO:0060395; GO:0070700; GO:0071260; GO:0071773 0 0 0 PF00019;PF00688; P52333 CHOYP_LOC100704264.1.1 m.49420 sp JAK3_HUMAN 28.405 602 371 19 806 1381 524 1091 3.07E-56 217 JAK3_HUMAN reviewed Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) JAK3 Homo sapiens (Human) 1124 adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; cell migration [GO:0016477]; enzyme linked receptor protein signaling pathway [GO:0007167]; innate immune response [GO:0045087]; interleukin-4-mediated signaling pathway [GO:0035771]; intracellular signal transduction [GO:0035556]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; MAPK cascade [GO:0000165]; negative regulation of dendritic cell cytokine production [GO:0002731]; negative regulation of FasL biosynthetic process [GO:0045221]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of thymocyte apoptotic process [GO:0070244]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of immune response [GO:0050778]; positive regulation of T cell proliferation [GO:0042102]; protein phosphorylation [GO:0006468]; regulation of T cell apoptotic process [GO:0070232]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to interleukin-9 [GO:0071104]; STAT protein import into nucleus [GO:0007262]; T cell homeostasis [GO:0043029]; tyrosine phosphorylation of Stat5 protein [GO:0042506]; tyrosine phosphorylation of STAT protein [GO:0007260] GO:0000165; GO:0002250; GO:0002731; GO:0004713; GO:0004715; GO:0005088; GO:0005102; GO:0005524; GO:0005829; GO:0005856; GO:0006468; GO:0007167; GO:0007204; GO:0007260; GO:0007262; GO:0012505; GO:0016477; GO:0018108; GO:0019903; GO:0030183; GO:0031234; GO:0032693; GO:0032695; GO:0035556; GO:0035771; GO:0038083; GO:0042102; GO:0042104; GO:0042506; GO:0043029; GO:0045087; GO:0045221; GO:0045626; GO:0050778; GO:0050868; GO:0051928; GO:0060397; GO:0070232; GO:0070244; GO:0070669; GO:0070670; GO:0070672; GO:0071104 0 0 0 PF07714; P62744 CHOYP_AP2S1.1.1 m.61530 sp AP2S1_RAT 95.775 142 6 0 1 142 1 142 3.07E-98 281 AP2S1_RAT reviewed AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma-adaptin 3b) (Sigma2-adaptin) Ap2s1 Ap17 Claps2 Rattus norvegicus (Rat) 142 endocytosis [GO:0006897]; intracellular protein transport [GO:0006886] GO:0005794; GO:0005886; GO:0006886; GO:0006897; GO:0008565; GO:0030121; GO:0030122 0 0 0 PF01217; Q01528 CHOYP_PROM1.3.3 m.58804 sp HAAF_LIMPO 40.237 169 94 4 6 171 4 168 3.07E-39 134 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q07076 CHOYP_ANXA7.1.4 m.4514 sp ANXA7_MOUSE 50.864 405 155 6 489 891 101 463 3.07E-122 381 ANXA7_MOUSE reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) Anxa7 Anx7 Mus musculus (Mouse) 463 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; membrane fusion [GO:0061025]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to calcium ion [GO:0051592]; response to organic cyclic compound [GO:0014070]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005178; GO:0005509; GO:0005544; GO:0005634; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0014070; GO:0016020; GO:0030855; GO:0031982; GO:0035176; GO:0042584; GO:0044822; GO:0048306; GO:0051592; GO:0061025; GO:0070062 0 0 0 PF00191; Q14BN4 CHOYP_SLMAP.7.8 m.63578 sp SLMAP_HUMAN 50.992 504 220 7 16 499 3 499 3.07E-146 459 SLMAP_HUMAN reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) 828 muscle contraction [GO:0006936] GO:0005790; GO:0005815; GO:0005887; GO:0006936; GO:0042383 0 0 0 PF00498; Q26481 CHOYP_RL5.2.4 m.35029 sp RL5_STYCL 76.271 295 69 1 10 304 1 294 3.07E-169 474 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q28740 CHOYP_OBSCN.1.2 m.24602 sp BASI_RABIT 27.461 193 123 7 190 372 82 267 3.07E-12 69.7 BASI_RABIT reviewed Basigin (CD antigen CD147) BSG Oryctolagus cuniculus (Rabbit) 270 protein targeting to plasma membrane [GO:0072661] GO:0005537; GO:0005887; GO:0042470; GO:0072661 0 0 0 0 Q3KQ77 CHOYP_EFCAB1.1.1 m.43342 sp EFCB1_XENLA 61.453 179 65 2 26 200 19 197 3.07E-76 231 EFCB1_XENLA reviewed EF-hand calcium-binding domain-containing protein 1 efcab1 Xenopus laevis (African clawed frog) 208 0 GO:0005509 0 0 0 PF13499; Q4LDE5 CHOYP_LOC100367084.15.22 m.52853 sp SVEP1_HUMAN 24.709 688 418 19 156 759 435 1106 3.07E-38 159 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4UMH6 CHOYP_TVAG_452670.1.2 m.21539 sp Y381_RICFE 26.613 372 223 13 294 640 638 984 3.07E-18 93.6 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5R833 CHOYP_ACO13.1.1 m.30659 sp ACO13_PONAB 58.333 132 55 0 31 162 8 139 3.07E-50 160 ACO13_PONAB reviewed "Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Thioesterase superfamily member 2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]" ACOT13 THEM2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 140 0 GO:0005634; GO:0005739; GO:0005819; GO:0005829; GO:0016787 0 0 0 PF03061; Q5ZLA6 CHOYP_MYO1C.3.3 m.38308 sp MYO1C_CHICK 50.714 140 69 0 1 140 675 814 3.07E-41 149 MYO1C_CHICK reviewed Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb) MYO1C RCJMB04_6o17 Gallus gallus (Chicken) 1028 0 GO:0001726; GO:0003774; GO:0005524; GO:0016023; GO:0016459; GO:0060171 0 0 0 PF00063;PF06017; Q640V9 CHOYP_LOC580466.2.2 m.61336 sp TATD1_XENLA 63.396 265 95 1 10 274 2 264 3.07E-125 361 TATD1_XENLA reviewed Putative deoxyribonuclease TATDN1 (EC 3.1.21.-) tatdn1 Xenopus laevis (African clawed frog) 297 0 GO:0005634; GO:0016888; GO:0046872 0 0 0 PF01026; Q66II5 CHOYP_T3HPD.1.2 m.24627 sp T3HPD_XENTR 53.614 332 153 1 9 339 17 348 3.07E-131 381 T3HPD_XENTR reviewed Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-L-proline dehydratase) l3hypdh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 348 metabolic process [GO:0008152] GO:0008152; GO:0016836; GO:0050346 0 0 0 PF05544; Q7T3Q2 CHOYP_CRIM1.3.3 m.8057 sp CRIM1_DANRE 37.514 885 448 22 19 816 9 875 3.07E-165 513 CRIM1_DANRE reviewed Cysteine-rich motor neuron 1 protein (CRIM-1) crim1 Danio rerio (Zebrafish) (Brachydanio rerio) 1027 blood vessel development [GO:0001568]; notochord morphogenesis [GO:0048570]; regulation of cell growth [GO:0001558]; somitogenesis [GO:0001756] GO:0001558; GO:0001568; GO:0001756; GO:0004867; GO:0005576; GO:0016021; GO:0048570 0 0 0 PF02822;PF00219;PF00093; Q7Z4M0 CHOYP_R114L.1.1 m.49434 sp RE114_HUMAN 25.306 245 127 9 9 201 21 261 3.07E-13 69.7 RE114_HUMAN reviewed Meiotic recombination protein REC114 REC114 C15orf60 Homo sapiens (Human) 266 DNA recombination [GO:0006310]; meiotic cell cycle [GO:0051321] GO:0006310; GO:0051321 0 0 0 PF15165; Q8CE72 CHOYP_LOC100894098.1.1 m.18656 sp CE042_MOUSE 29.027 627 382 15 1 585 21 626 3.07E-62 228 CE042_MOUSE reviewed Uncharacterized protein C5orf42 homolog 0 Mus musculus (Mouse) 3214 cardiac septum development [GO:0003279]; cerebellum development [GO:0021549]; cilium assembly [GO:0042384]; coronary vasculature development [GO:0060976]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; heart development [GO:0007507]; kidney development [GO:0001822]; palate development [GO:0060021]; protein localization to ciliary transition zone [GO:1904491]; ventricular septum development [GO:0003281] GO:0001736; GO:0001822; GO:0003279; GO:0003281; GO:0007507; GO:0016021; GO:0021549; GO:0035869; GO:0042384; GO:0042733; GO:0060021; GO:0060976; GO:1904491 0 0 0 PF15392; Q8IV33 CHOYP_BRAFLDRAFT_67683.1.1 m.4856 sp K0825_HUMAN 34.043 376 217 9 47 412 478 832 3.07E-52 191 K0825_HUMAN reviewed Uncharacterized protein KIAA0825 KIAA0825 C5orf36 Homo sapiens (Human) 1275 0 0 0 0 0 PF14906; Q8IWZ3 CHOYP_LOC100637968.5.12 m.32613 sp ANKH1_HUMAN 31.628 430 271 15 328 741 212 634 3.07E-35 148 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.11.34 m.31281 sp VWDE_HUMAN 27.248 367 239 14 1138 1485 749 1106 3.07E-19 98.6 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8R151 CHOYP_ZNFX1.11.12 m.63397 sp ZNFX1_MOUSE 41.627 418 230 5 2 418 1502 1906 3.07E-104 342 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8TE57 CHOYP_ATS16.2.4 m.14579 sp ATS16_HUMAN 31.501 946 533 27 31 889 69 986 3.07E-121 413 ATS16_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) ADAMTS16 KIAA2029 Homo sapiens (Human) 1224 branching involved in ureteric bud morphogenesis [GO:0001658]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] GO:0001658; GO:0003073; GO:0004222; GO:0005578; GO:0008270; GO:1902017 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q8WZ42 CHOYP_LOC100367089.1.4 m.1388 sp TITIN_HUMAN 34.783 92 60 0 1609 1700 104 195 3.07E-09 66.2 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q91ZT9 CHOYP_LOC100185060.2.2 m.18100 sp ASB8_MOUSE 39.024 164 93 5 157 318 35 193 3.07E-21 98.6 ASB8_MOUSE reviewed Ankyrin repeat and SOCS box protein 8 (ASB-8) Asb8 Mus musculus (Mouse) 288 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005737; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q96AH0 CHOYP_SOSB1.2.2 m.10758 sp SOSB2_HUMAN 46.89 209 94 5 8 214 11 204 3.07E-54 175 SOSB2_HUMAN reviewed SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2) NABP1 OBFC2A SSB2 Homo sapiens (Human) 204 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; mitotic cell cycle checkpoint [GO:0007093]; response to ionizing radiation [GO:0010212]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0000724; GO:0000784; GO:0003697; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006974; GO:0007093; GO:0010212; GO:0042795; GO:0070876 0 0 0 0 Q9H4G4 CHOYP_ISCW_ISCW019177.1.4 m.20847 sp GAPR1_HUMAN 46.957 115 55 3 24 138 9 117 3.07E-27 103 GAPR1_HUMAN reviewed Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) 154 positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374 0 0 0 PF00188; Q9LDH0 CHOYP_RCOM_0046280.1.1 m.65577 sp XYLT_ARATH 24.44 491 251 17 47 449 67 525 3.07E-25 112 XYLT_ARATH reviewed "Beta-(1,2)-xylosyltransferase (EC 2.4.2.38)" XYLT At5g55500 MTE17.21 Arabidopsis thaliana (Mouse-ear cress) 534 "posttranslational protein targeting to membrane, translocation [GO:0031204]; protein N-linked glycosylation [GO:0006487]" GO:0000139; GO:0005794; GO:0005797; GO:0006487; GO:0016021; GO:0031204; GO:0032580; GO:0042285; GO:0050513 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04577; Q9U639 CHOYP_BRAFLDRAFT_114843.1.2 m.14730 sp HSP7D_MANSE 87.097 93 12 0 1 93 314 406 3.07E-49 167 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9UL36 CHOYP_BRAFLDRAFT_98113.1.1 m.46999 sp ZN236_HUMAN 38.37 920 400 30 1065 1867 964 1833 3.07E-147 504 ZN236_HUMAN reviewed Zinc finger protein 236 ZNF236 Homo sapiens (Human) 1845 "cellular response to glucose stimulus [GO:0071333]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872; GO:0071333 0 0 0 PF00096;PF13912; B3A0Q9 CHOYP_IBP1.1.1 m.1039 sp PLSLP_LOTGI 38.462 91 54 2 9 97 12 102 3.08E-08 51.2 PLSLP_LOTGI reviewed Perlustrin-like protein 0 Lottia gigantea (Giant owl limpet) 121 regulation of cell growth [GO:0001558] GO:0001558; GO:0005576 0 0 0 0 D3ZAT9 CHOYP_LOC100377010.13.16 m.57298 sp FAXC_RAT 35.019 257 146 6 31 275 87 334 3.08E-50 173 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; I3LM39 CHOYP_NEMVEDRAFT_V1G196611.1.13 m.3128 sp CGAS_PIG 27.586 174 95 8 109 258 318 484 3.08E-06 53.5 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O95260 CHOYP_LOC100541056.1.1 m.11424 sp ATE1_HUMAN 47.093 516 221 9 22 490 8 518 3.08E-151 444 ATE1_HUMAN reviewed Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) ATE1 Homo sapiens (Human) 518 protein arginylation [GO:0016598] GO:0004057; GO:0005634; GO:0005737; GO:0016598 0 0 0 PF04377;PF04376; P02434 CHOYP_BRAFLDRAFT_277091.2.3 m.33938 sp RL35A_XENLA 71.56 109 30 1 44 152 3 110 3.08E-51 161 RL35A_XENLA reviewed 60S ribosomal protein L35a (L32) rpl35a Xenopus laevis (African clawed frog) 110 translation [GO:0006412] GO:0000049; GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01247; P09874 CHOYP_BRAFLDRAFT_203655.1.2 m.12 sp PARP1_HUMAN 42.609 115 60 2 1 114 696 805 3.08E-23 96.3 PARP1_HUMAN reviewed Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) PARP1 ADPRT PPOL Homo sapiens (Human) 1014 "ATP generation from poly-ADP-D-ribose [GO:1990966]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; DNA damage response, detection of DNA damage [GO:0042769]; DNA ligation involved in DNA repair [GO:0051103]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; global genome nucleotide-excision repair [GO:0070911]; lagging strand elongation [GO:0006273]; macrophage differentiation [GO:0030225]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA duplex unwinding [GO:0000717]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of SMAD protein import into nucleus [GO:0060391]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein ADP-ribosylation [GO:0006471]; protein autoprocessing [GO:0016540]; protein modification process [GO:0036211]; protein poly-ADP-ribosylation [GO:0070212]; protein sumoylation [GO:0016925]; regulation of cellular protein localization [GO:1903827]; signal transduction involved in regulation of gene expression [GO:0023019]; transcription from RNA polymerase II promoter [GO:0006366]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000122; GO:0000715; GO:0000717; GO:0000724; GO:0000784; GO:0003677; GO:0003910; GO:0003950; GO:0005634; GO:0005635; GO:0005654; GO:0005667; GO:0005730; GO:0005739; GO:0006273; GO:0006281; GO:0006293; GO:0006294; GO:0006295; GO:0006296; GO:0006302; GO:0006366; GO:0006471; GO:0006974; GO:0007005; GO:0007179; GO:0008134; GO:0008270; GO:0010613; GO:0016020; GO:0016540; GO:0016925; GO:0019899; GO:0019901; GO:0023019; GO:0030225; GO:0032042; GO:0032869; GO:0033683; GO:0034599; GO:0036211; GO:0042769; GO:0042802; GO:0043234; GO:0043504; GO:0044822; GO:0045944; GO:0047485; GO:0051103; GO:0051287; GO:0060391; GO:0070212; GO:0070911; GO:1903827; GO:1904357; GO:1990966; GO:2000679 0 0 0 PF00533;PF08063;PF00644;PF02877;PF05406;PF00645; P0CT33 CHOYP_LOC100370129.2.4 m.30261 sp TLH1_SCHPO 29.371 143 87 3 21 161 1446 1576 3.08E-13 70.9 TLH1_SCHPO reviewed ATP-dependent DNA helicase tlh1 (EC 3.6.4.12) (Sub-telomeric helicase RecQ homolog 1) (Fragment) tlh1 SPAC212.11 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1887 base-excision repair [GO:0006284]; cell aging [GO:0007569]; cellular response to gamma radiation [GO:0071480]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; replication fork processing [GO:0031297]; telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000731; GO:0000784; GO:0003677; GO:0005524; GO:0005654; GO:0005737; GO:0006284; GO:0006302; GO:0007569; GO:0008270; GO:0009378; GO:0031297; GO:0043140; GO:0071480 0 0 0 PF00270;PF00271; P42577 CHOYP_LOC100222774.1.1 m.56991 sp FRIS_LYMST 82.036 167 30 0 1 167 1 167 3.08E-101 291 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P54277 CHOYP_PMS1.3.3 m.43630 sp PMS1_HUMAN 29.282 362 217 9 22 359 577 923 3.08E-33 134 PMS1_HUMAN reviewed PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) PMS1 PMSL1 Homo sapiens (Human) 932 mismatch repair [GO:0006298] GO:0000795; GO:0003677; GO:0003697; GO:0005524; GO:0005634; GO:0005712; GO:0006298; GO:0016887; GO:0030983; GO:0032389 0 0 0 PF01119;PF00505; P62909 CHOYP_RS3.1.7 m.3663 sp RS3_RAT 92.188 192 15 0 15 206 1 192 3.08E-128 364 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; P80147 CHOYP_GABT.1.2 m.672 sp GABT_PIG 53.864 440 203 0 1 440 59 498 3.08E-180 515 GABT_PIG reviewed "4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT)" ABAT GABAT Sus scrofa (Pig) 500 behavioral response to cocaine [GO:0048148]; gamma-aminobutyric acid catabolic process [GO:0009450]; neurotransmitter catabolic process [GO:0042135] GO:0003867; GO:0005739; GO:0005759; GO:0005829; GO:0009450; GO:0030170; GO:0032144; GO:0032145; GO:0042135; GO:0042803; GO:0046872; GO:0047298; GO:0048148; GO:0051537 0 0 cd00610; PF00202; Q0E908 CHOYP_HIL.1.1 m.29640 sp HIL_DROME 30.528 796 461 24 51 784 11 776 3.08E-103 342 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q0VA03 CHOYP_LOC100692988.1.1 m.10675 sp SUZ12_XENTR 41.997 631 323 14 12 606 24 647 3.08E-167 496 SUZ12_XENTR reviewed Polycomb protein suz12 (Suppressor of zeste 12 protein homolog) suz12 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 700 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0016569; GO:0035098; GO:0046872 0 0 0 PF09733; Q17QJ5 CHOYP_LOC751836.3.6 m.30605 sp TSN5_BOVIN 25.379 264 176 5 5 268 12 254 3.08E-22 96.3 TSN5_BOVIN reviewed Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) 268 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007166; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q3T0Y3 CHOYP_BRAFLDRAFT_284846.2.2 m.60101 sp ST1B1_BOVIN 35.172 290 158 10 43 315 19 295 3.08E-40 145 ST1B1_BOVIN reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) 296 epithelial cell differentiation [GO:0030855]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005737; GO:0006805; GO:0008202; GO:0009812; GO:0030855; GO:0042403; GO:0051923 0 0 0 PF00685; Q3UIR3 CHOYP_DTX3L.1.4 m.45660 sp DTX3L_MOUSE 50.455 220 102 4 788 1001 529 747 3.08E-61 226 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q5RFZ7 CHOYP_FAM167A.1.2 m.21107 sp F167A_DANRE 34.021 194 102 6 37 213 20 204 3.08E-23 95.5 F167A_DANRE reviewed Protein FAM167A fam167a si:ch211-261f7.2 Danio rerio (Zebrafish) (Brachydanio rerio) 204 0 0 0 0 0 PF11652; Q6PDJ1 CHOYP_CACHD1.1.1 m.62557 sp CAHD1_MOUSE 26.963 1146 731 42 6 1089 39 1140 3.08E-98 343 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6XD76 CHOYP_LOC778542.1.1 m.10393 sp ASCL4_HUMAN 59.459 74 25 1 72 145 63 131 3.08E-21 90.9 ASCL4_HUMAN reviewed Achaete-scute homolog 4 (ASH-4) (hASH4) (Achaete-scute-like protein 4) (Class A basic helix-loop-helix protein 44) (bHLHa44) ASCL4 BHLHA44 HASH4 Homo sapiens (Human) 172 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; skin development [GO:0043588]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0006351; GO:0006357; GO:0043588; GO:0090575 0 0 0 PF00010; Q7T3H9 CHOYP_HYI.1.1 m.10528 sp HYI_DANRE 51.711 263 123 2 26 284 4 266 3.08E-97 290 HYI_DANRE reviewed Putative hydroxypyruvate isomerase (EC 5.3.1.22) hyi zgc:63850 Danio rerio (Zebrafish) (Brachydanio rerio) 276 0 GO:0008903 0 0 0 PF01261; Q91312 CHOYP_CRYAB.5.5 m.49919 sp CRYAB_LITCT 36.667 120 72 3 9 126 48 165 3.08E-18 79 CRYAB_LITCT reviewed Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 173 0 GO:0005212; GO:0042803; GO:0046872 0 0 0 PF00525;PF00011; Q96WV6 CHOYP_contig_003697 m.4180 sp YHU2_SCHPO 34.872 195 121 1 1 195 800 988 3.08E-07 53.5 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q99M80 CHOYP_LOC100497631.1.2 m.57311 sp PTPRT_MOUSE 27.322 743 493 16 232 937 721 1453 3.08E-75 273 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_88223.18.22 m.60188 sp TRIM2_MOUSE 29.67 182 98 9 324 492 536 700 3.08E-09 63.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9USY1 CHOYP_ZGC_136858.1.1 m.51274 sp YOW5_SCHPO 25.758 528 323 14 9 479 225 740 3.08E-33 137 YOW5_SCHPO reviewed Pseudouridine-metabolizing bifunctional protein C1861.05 [Includes: Pseudouridine-5'-phosphate glycosidase (PsiMP glycosidase) (EC 4.2.1.70); Pseudouridine kinase (EC 2.7.1.83)] SPBC1861.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 747 0 GO:0004730; GO:0005524; GO:0005737; GO:0016798; GO:0046872; GO:0050225 0 0 0 PF04227;PF00294; A1A4V9 CHOYP_LOC100376096.1.1 m.62366 sp CC189_HUMAN 38.4 250 143 5 42 289 76 316 3.09E-54 183 CC189_HUMAN reviewed Coiled-coil domain-containing protein 189 CCDC189 C16orf93 Homo sapiens (Human) 331 0 0 0 0 0 PF14769; A4IF63 CHOYP_BRAFLDRAFT_109857.10.15 m.39410 sp TRIM2_BOVIN 23.288 219 136 7 50 252 492 694 3.09E-07 54.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B2RQL2 CHOYP_STOX1.1.1 m.18778 sp STOX1_MOUSE 29.243 383 204 11 32 404 12 337 3.09E-39 161 STOX1_MOUSE reviewed Storkhead-box protein 1 Stox1 Mus musculus (Mouse) 990 "cell division [GO:0051301]; cellular response to nitrosative stress [GO:0071500]; inner ear development [GO:0048839]; mitotic nuclear division [GO:0007067]; negative regulation of gene expression [GO:0010629]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of gene expression [GO:0010628]; positive regulation of otic vesicle morphogenesis [GO:1904120]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of gene expression [GO:0010468]; regulation of mitochondrial DNA metabolic process [GO:1901858]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of response to oxidative stress [GO:1902882]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0005938; GO:0006351; GO:0007067; GO:0008284; GO:0010468; GO:0010628; GO:0010629; GO:0010800; GO:0010821; GO:0010971; GO:0033138; GO:0045787; GO:0048839; GO:0050679; GO:0051301; GO:0051881; GO:0051897; GO:0061418; GO:0071500; GO:1901858; GO:1902882; GO:1904031; GO:1904120 0 0 0 PF10264; O70445 CHOYP_BARD1.1.1 m.18437 sp BARD1_MOUSE 36.364 396 214 10 271 653 395 765 3.09E-67 238 BARD1_MOUSE reviewed BRCA1-associated RING domain protein 1 (BARD-1) (EC 6.3.2.-) Bard1 Mus musculus (Mouse) 765 DNA repair [GO:0006281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of apoptotic process [GO:0043065]; protein K6-linked ubiquitination [GO:0085020]; regulation of phosphorylation [GO:0042325] GO:0003723; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0008270; GO:0016874; GO:0031436; GO:0042325; GO:0042803; GO:0043065; GO:0043066; GO:0043231; GO:0046826; GO:0046982; GO:0070531; GO:0085020 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; O75382 CHOYP_BRAFLDRAFT_205965.6.43 m.13242 sp TRIM3_HUMAN 27.049 122 85 2 131 248 622 743 3.09E-08 57.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P42577 CHOYP_FRIS.6.11 m.44036 sp FRIS_LYMST 83.929 168 27 0 1 168 1 168 3.09E-103 299 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P49154 CHOYP_LSG1.1.1 m.14763 sp RS2_URECA 88.068 176 21 0 66 241 39 214 3.09E-110 322 RS2_URECA reviewed 40S ribosomal protein S2 RPS2 Urechis caupo (Innkeeper worm) (Spoonworm) 278 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; P49395 CHOYP_RS3A.8.15 m.27209 sp RS3A_APLCA 83.908 174 28 0 1 174 1 174 3.09E-99 290 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P58557 CHOYP_YBEY.1.1 m.48439 sp YBEY_HUMAN 43.506 154 86 1 1 154 1 153 3.09E-47 154 YBEY_HUMAN reviewed Putative ribonuclease YBEY C21orf57 Homo sapiens (Human) 167 rRNA processing [GO:0006364] GO:0004222; GO:0005634; GO:0005654; GO:0005739; GO:0006364; GO:0046872 0 0 0 PF02130; Q26481 CHOYP_LOC100186763.1.2 m.3464 sp RL5_STYCL 84.541 207 32 0 1 207 1 207 3.09E-134 381 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q52KI8 CHOYP_LOC588572.2.2 m.58133 sp SRRM1_MOUSE 62.025 79 27 2 1 79 85 160 3.09E-23 98.6 SRRM1_MOUSE reviewed Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101) Srrm1 Pop101 Mus musculus (Mouse) 946 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0003677; GO:0005681; GO:0016363; GO:0016607 0 0 0 PF01480; Q5ZLC6 CHOYP_ANR10.1.2 m.23477 sp ANR10_CHICK 38.132 257 132 4 8 260 7 240 3.09E-48 169 ANR10_CHICK reviewed Ankyrin repeat domain-containing protein 10 ANKRD10 RCJMB04_6l10 Gallus gallus (Chicken) 414 regulation of canonical Wnt signaling pathway [GO:0060828] GO:0060828 0 0 0 PF12796; Q62283 CHOYP_DMOJ_GI24618.1.1 m.55898 sp TSN7_MOUSE 27.615 239 150 6 9 242 14 234 3.09E-26 105 TSN7_MOUSE reviewed Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (PE31) (TALLA homolog) (Transmembrane 4 superfamily member 2) (CD antigen CD231) Tspan7 Mxs1 Tm4sf2 Mus musculus (Mouse) 249 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q69ZZ6 CHOYP_BRAFLDRAFT_212113.1.1 m.60315 sp TMCC1_MOUSE 42.972 498 220 13 61 533 187 645 3.09E-103 327 TMCC1_MOUSE reviewed Transmembrane and coiled-coil domains protein 1 Tmcc1 Kiaa0779 Mus musculus (Mouse) 649 0 GO:0005789; GO:0016021 0 0 0 PF10267; Q6DE14 CHOYP_E2F4.1.1 m.25398 sp E2F4_XENLA 54.922 386 120 13 39 392 10 373 3.09E-114 341 E2F4_XENLA reviewed Transcription factor E2F4 (E2F-4) e2f4 Xenopus laevis (African clawed frog) 375 "centriole assembly [GO:0098534]; mitotic cell cycle [GO:0000278]; motile cilium assembly [GO:0044458]; multi-ciliated epithelial cell differentiation [GO:1903251]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000278; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0044458; GO:0045944; GO:0098534; GO:1903251 0 0 cd14660; PF16421;PF02319; Q6Q311 CHOYP_PLCB4.2.2 m.24259 sp RS25_SHEEP 73.118 93 21 1 55 143 33 125 3.09E-34 119 RS25_SHEEP reviewed 40S ribosomal protein S25 RPS25 Ovis aries (Sheep) 125 0 GO:0005840 0 0 0 PF03297; Q6R7F8 CHOYP_Y071.1.1 m.29247 sp Y070_OSHVF 100 159 0 0 1 159 1 159 3.09E-118 338 Y070_OSHVF reviewed Uncharacterized protein ORF70 ORF70 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 200 0 0 0 0 0 0 Q6TLF6 CHOYP_LOC754557.1.2 m.5492 sp RGN_DANRE 41.722 302 165 5 8 308 4 295 3.09E-73 230 RGN_DANRE reviewed Regucalcin (RC) (Gluconolactonase) (GNL) (EC 3.1.1.17) rgn zgc:92078 Danio rerio (Zebrafish) (Brachydanio rerio) 295 cellular calcium ion homeostasis [GO:0006874]; L-ascorbic acid biosynthetic process [GO:0019853]; positive regulation of ATPase activity [GO:0032781]; regulation of calcium-mediated signaling [GO:0050848] GO:0004341; GO:0005509; GO:0005634; GO:0005737; GO:0006874; GO:0008270; GO:0019853; GO:0030234; GO:0032781; GO:0050848 PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis via UDP-alpha-D-glucuronate pathway; L-ascorbate from UDP-alpha-D-glucuronate: step 3/4. 0 0 PF08450; Q8BR65 CHOYP_SDS3.1.1 m.51736 sp SDS3_MOUSE 58.562 292 101 6 40 322 45 325 3.09E-110 326 SDS3_MOUSE reviewed Sin3 histone deacetylase corepressor complex component SDS3 (Suppressor of defective silencing 3 protein homolog) Suds3 Sds3 Mus musculus (Mouse) 328 "apoptotic process [GO:0006915]; histone deacetylation [GO:0016575]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0016575; GO:0016580; GO:0019899; GO:0042802; GO:0042803; GO:0042826; GO:0043065; GO:0045892 0 0 0 PF08598; Q8BZ20 CHOYP_PAR12.1.1 m.24820 sp PAR12_MOUSE 43.077 130 71 2 464 592 491 618 3.09E-22 106 PAR12_MOUSE reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) 711 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q92193 CHOYP_ACT.20.27 m.57351 sp ACT_CRAVI 85.185 81 11 1 10 90 44 123 3.09E-41 139 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q99996 CHOYP_LOC582174.10.16 m.42001 sp AKAP9_HUMAN 43.258 178 88 3 73 245 3584 3753 3.09E-30 122 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q99M80 CHOYP_MEG10.66.91 m.52526 sp PTPRT_MOUSE 31.136 713 422 17 770 1435 763 1453 3.09E-81 298 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9NFP5 CHOYP_LOC100863791.2.2 m.44582 sp SH3BG_DROME 43.59 117 56 3 1 108 1 116 3.09E-24 100 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9UIL4 CHOYP_BRAFLDRAFT_84054.2.2 m.18483 sp KIF25_HUMAN 49.086 383 160 6 202 574 18 375 3.09E-112 343 KIF25_HUMAN reviewed Kinesin-like protein KIF25 (Kinesin-like protein 3) KIF25 KNSL3 Homo sapiens (Human) 384 microtubule-based movement [GO:0007018]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of autophagy [GO:0010507]; organelle organization [GO:0006996] GO:0000070; GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0006996; GO:0007018; GO:0010507; GO:0016887 0 0 0 PF00225; A1A4M6 CHOYP_STAR5.2.2 m.39352 sp STAR5_BOVIN 44.118 204 112 2 5 207 8 210 3.10E-55 177 STAR5_BOVIN reviewed StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5) STARD5 Bos taurus (Bovine) 213 lipid transport [GO:0006869] GO:0006869; GO:0032052 0 0 0 PF01852; F6QEU4 CHOYP_LOC100376215.15.19 m.40944 sp LIN41_XENTR 21.304 230 140 8 19 208 141 369 3.10E-06 50.4 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O00370 CHOYP_LOC100555596.2.2 m.35337 sp LORF2_HUMAN 34.366 355 225 3 6 356 389 739 3.10E-53 193 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O14594 CHOYP_LOC100369221.1.1 m.5197 sp NCAN_HUMAN 30.872 149 78 5 41 188 1097 1221 3.10E-15 77.4 NCAN_HUMAN reviewed Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 NEUR Homo sapiens (Human) 1321 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate biosynthetic process [GO:0030208]; extracellular matrix organization [GO:0030198]; glycosaminoglycan metabolic process [GO:0030203]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005576; GO:0005578; GO:0005796; GO:0007155; GO:0007417; GO:0030198; GO:0030203; GO:0030206; GO:0030207; GO:0030208; GO:0030246; GO:0043202 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; O43396 CHOYP_LOC100893535.1.1 m.27958 sp TXNL1_HUMAN 55.052 287 125 3 27 310 4 289 3.10E-113 332 TXNL1_HUMAN reviewed Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein) TXNL1 TRP32 TXL TXNL Homo sapiens (Human) 289 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; protein folding [GO:0006457]; sulfate assimilation [GO:0000103] GO:0000103; GO:0000502; GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0006662; GO:0015035; GO:0015036; GO:0016671; GO:0034599; GO:0045454; GO:0070062 0 0 0 PF06201;PF00085; O70277 CHOYP_LOC100373444.15.79 m.20575 sp TRIM3_RAT 30.657 137 89 3 60 194 110 242 3.10E-08 60.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P18173 CHOYP_LOC100877446.2.2 m.58045 sp DHGL_DROME 39.794 583 304 13 36 604 65 614 3.10E-125 385 DHGL_DROME reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld CG1152 Drosophila melanogaster (Fruit fly) 625 glucose metabolic process [GO:0006006]; pupal chitin-based cuticle development [GO:0008364]; sensory perception of pain [GO:0019233]; sperm storage [GO:0046693] GO:0005576; GO:0006006; GO:0008364; GO:0016614; GO:0019233; GO:0046693; GO:0050660 0 0 0 PF05199;PF00732; P22001 CHOYP_KCNAB.1.1 m.33662 sp KCNA3_HUMAN 25.8 469 249 12 24 480 106 487 3.10E-40 156 KCNA3_HUMAN reviewed Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) KCNA3 HGK5 Homo sapiens (Human) 575 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260] GO:0005244; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0015271; GO:0030424; GO:0045121; GO:0051260 0 0 0 PF02214;PF00520; P35991 CHOYP_TEC.1.1 m.54460 sp BTK_MOUSE 25.197 381 243 13 1 352 1 368 3.10E-29 122 BTK_MOUSE reviewed Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) (Kinase EMB) Btk Bpk Mus musculus (Mouse) 659 "adaptive immune response [GO:0002250]; apoptotic process [GO:0006915]; cell maturation [GO:0048469]; Fc-epsilon receptor signaling pathway [GO:0038095]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; innate immune response [GO:0045087]; negative regulation of cytokine production [GO:0001818]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]" GO:0001818; GO:0002250; GO:0004713; GO:0004715; GO:0005524; GO:0005547; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0007169; GO:0007249; GO:0018108; GO:0031234; GO:0031410; GO:0038083; GO:0038095; GO:0042127; GO:0042802; GO:0043231; GO:0045087; GO:0045121; GO:0046872; GO:0048469 0 0 0 PF00779;PF00169;PF07714;PF00017;PF00018; P42519 CHOYP_STAR.4.4 m.54302 sp STAR_DROME 22.353 170 112 3 105 254 395 564 3.10E-06 51.6 STAR_DROME reviewed Protein Star S CG4385 Drosophila melanogaster (Fruit fly) 597 "behavioral response to ethanol [GO:0048149]; branched duct epithelial cell fate determination, open tracheal system [GO:0046845]; compound eye photoreceptor cell differentiation [GO:0001751]; compound eye retinal cell programmed cell death [GO:0046667]; determination of genital disc primordium [GO:0035225]; epidermal growth factor receptor ligand maturation [GO:0038004]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; imaginal disc-derived wing morphogenesis [GO:0007476]; ommatidial rotation [GO:0016318]; oogenesis [GO:0048477]; protein targeting to Golgi [GO:0000042]; R7 cell development [GO:0045467]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; stem cell fate commitment [GO:0048865]; stomatogastric nervous system development [GO:0007421]; visual perception [GO:0007601]" GO:0000042; GO:0000139; GO:0001751; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0007173; GO:0007421; GO:0007476; GO:0007601; GO:0016020; GO:0016021; GO:0016318; GO:0035225; GO:0038004; GO:0042058; GO:0045467; GO:0046667; GO:0046845; GO:0048149; GO:0048477; GO:0048865; GO:0061331; GO:0097038 0 0 0 0 Q00724 CHOYP_LOC100725967.1.1 m.30507 sp RET4_MOUSE 30.508 177 108 10 3 177 29 192 3.10E-12 65.5 RET4_MOUSE reviewed Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) Rbp4 Mus musculus (Mouse) 201 cardiac muscle tissue development [GO:0048738]; detection of light stimulus involved in visual perception [GO:0050908]; embryonic organ morphogenesis [GO:0048562]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; embryonic skeletal system development [GO:0048706]; eye development [GO:0001654]; female genitalia morphogenesis [GO:0048807]; gluconeogenesis [GO:0006094]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; lung development [GO:0030324]; maintenance of gastrointestinal epithelium [GO:0030277]; male gonad development [GO:0008584]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of insulin secretion [GO:0032024]; response to insulin [GO:0032868]; response to retinoic acid [GO:0032526]; retina development in camera-type eye [GO:0060041]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]; retinol transport [GO:0034633]; spermatogenesis [GO:0007283]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068] GO:0001654; GO:0005615; GO:0006094; GO:0007283; GO:0007507; GO:0008584; GO:0016918; GO:0019841; GO:0030277; GO:0030324; GO:0032024; GO:0032526; GO:0032868; GO:0034632; GO:0034633; GO:0042572; GO:0042574; GO:0042593; GO:0048562; GO:0048706; GO:0048738; GO:0048807; GO:0050908; GO:0051024; GO:0060041; GO:0060044; GO:0060059; GO:0060065; GO:0060068; GO:0060157; GO:0060347; GO:0070062 0 0 0 PF00061; Q0VCS9 CHOYP_ANKY2.2.2 m.44213 sp ANKY2_BOVIN 52.212 226 106 1 17 240 5 230 3.10E-79 248 ANKY2_BOVIN reviewed Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 Bos taurus (Bovine) 442 0 GO:0005929; GO:0046872 0 0 0 PF12796;PF01753; Q28193 CHOYP_NEC2.1.1 m.12793 sp FURIN_BOVIN 43.088 557 306 7 8 553 17 573 3.10E-145 443 FURIN_BOVIN reviewed Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE) (Trans Golgi network protease furin) FURIN FUR PACE Bos taurus (Bovine) 797 protein processing [GO:0016485] GO:0004252; GO:0005615; GO:0005794; GO:0005886; GO:0016021; GO:0016485; GO:0046872 0 0 0 PF01483;PF00082;PF16470; Q3KNS6 CHOYP_ZN436.2.3 m.19680 sp ZN829_HUMAN 36.475 244 142 4 160 400 199 432 3.10E-47 170 ZN829_HUMAN reviewed Zinc finger protein 829 ZNF829 Homo sapiens (Human) 432 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q3SYV5 CHOYP_TSN33.2.3 m.48784 sp TSN33_BOVIN 33.088 272 166 6 115 382 21 280 3.10E-47 165 TSN33_BOVIN reviewed Tetraspanin-33 (Tspan-33) TSPAN33 Bos taurus (Bovine) 283 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747] GO:0005887; GO:0007166; GO:0045747; GO:0090002 0 0 0 PF00335; Q5EGY4 CHOYP_BRAFLDRAFT_126152.1.2 m.6003 sp YKT6_RAT 62.5 136 51 0 18 153 63 198 3.10E-59 185 YKT6_RAT reviewed Synaptobrevin homolog YKT6 (EC 2.3.1.-) Ykt6 Rattus norvegicus (Rat) 198 "ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903]" GO:0000139; GO:0000149; GO:0005484; GO:0005737; GO:0005739; GO:0005768; GO:0005783; GO:0005829; GO:0005887; GO:0006887; GO:0006888; GO:0006903; GO:0006904; GO:0006906; GO:0015031; GO:0016020; GO:0019706; GO:0030659; GO:0031201; GO:0042147; GO:0043025; GO:0070062; GO:0097440; GO:0097441 0 0 0 PF13774;PF00957; Q5R440 CHOYP_contig_034012 m.38658 sp CALX_PONAB 35.484 124 75 2 4 127 473 591 3.10E-11 62.4 CALX_PONAB reviewed Calnexin CANX Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 592 clathrin-mediated endocytosis [GO:0072583]; protein folding [GO:0006457]; synaptic vesicle endocytosis [GO:0048488] GO:0005509; GO:0005783; GO:0005789; GO:0006457; GO:0016021; GO:0030246; GO:0042470; GO:0045202; GO:0048488; GO:0072583 0 0 0 PF00262; Q5R5H1 CHOYP_MAT2A.1.1 m.40561 sp METK2_PONAB 70.522 268 73 1 19 286 9 270 3.10E-141 407 METK2_PONAB reviewed S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) MAT2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 395 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0004478; GO:0005524; GO:0006556; GO:0006730; GO:0046872; GO:0048269 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF02773;PF02772;PF00438; Q61805 CHOYP_LOC589952.4.5 m.31147 sp LBP_MOUSE 25 280 199 3 8 284 145 416 3.10E-23 102 LBP_MOUSE reviewed Lipopolysaccharide-binding protein (LBP) Lbp Mus musculus (Mouse) 481 "acute-phase response [GO:0006953]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of molecule of bacterial origin [GO:0032490]; innate immune response [GO:0045087]; leukocyte chemotaxis involved in inflammatory response [GO:0002232]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lipopolysaccharide transport [GO:0015920]; liver development [GO:0001889]; macrophage activation involved in immune response [GO:0002281]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of tumor necrosis factor production [GO:0032720]; opsonization [GO:0008228]; positive regulation of chemokine production [GO:0032722]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage activation [GO:0043032]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of respiratory burst involved in inflammatory response [GO:0060265]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of membrane permeability [GO:0090559]; response to lipopolysaccharide [GO:0032496]" GO:0001530; GO:0001889; GO:0002232; GO:0002281; GO:0005102; GO:0005615; GO:0006953; GO:0008228; GO:0009986; GO:0015920; GO:0016020; GO:0031663; GO:0032490; GO:0032496; GO:0032720; GO:0032722; GO:0032755; GO:0032757; GO:0032760; GO:0034145; GO:0042535; GO:0043032; GO:0044130; GO:0045087; GO:0050829; GO:0050830; GO:0060100; GO:0060265; GO:0070062; GO:0070891; GO:0071222; GO:0071223; GO:0090023; GO:0090559 0 0 0 PF01273;PF02886; Q6PGG2 CHOYP_BRAFLDRAFT_124122.1.1 m.61426 sp GMIP_MOUSE 32.07 686 376 18 229 837 85 757 3.10E-90 312 GMIP_MOUSE reviewed GEM-interacting protein (GMIP) Gmip Mus musculus (Mouse) 971 intracellular signal transduction [GO:0035556]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of GTPase activity [GO:0034260]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005096; GO:0005622; GO:0034260; GO:0035556; GO:0046872; GO:0098779; GO:0098792 0 0 0 PF00620; Q866F0 CHOYP_LOC100497569.1.2 m.25546 sp FUT1_SAIBB 26.829 287 178 8 74 348 87 353 3.10E-25 107 FUT1_SAIBB reviewed "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) 366 protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q86UW6 CHOYP_N4BP2.1.1 m.9547 sp N4BP2_HUMAN 33.816 414 242 10 1623 2012 1364 1769 3.10E-48 194 N4BP2_HUMAN reviewed NEDD4-binding protein 2 (N4BP2) (EC 3.-.-.-) (BCL-3-binding protein) N4BP2 B3BP KIAA1413 Homo sapiens (Human) 1770 0 GO:0004519; GO:0005524; GO:0005829; GO:0046404 0 0 0 PF08590;PF01713; Q8AWF2 CHOYP_LOC100209087.1.1 m.20249 sp NACA_ORENI 67.016 191 61 1 28 216 25 215 3.10E-72 221 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q8ND30 CHOYP_LOC100695320.2.2 m.15600 sp LIPB2_HUMAN 38.827 716 319 17 25 657 159 838 3.10E-143 443 LIPB2_HUMAN reviewed Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) PPFIBP2 Homo sapiens (Human) 876 0 GO:0005615; GO:0005622 0 0 0 PF00536;PF07647; Q96MN5 CHOYP_TEAN2.1.1 m.64512 sp TEAN2_HUMAN 50.242 207 97 2 1 204 1 204 3.10E-58 186 TEAN2_HUMAN reviewed Transcription elongation factor A N-terminal and central domain-containing protein 2 TCEANC2 C1orf83 Homo sapiens (Human) 208 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351 0 0 0 PF08711; Q99102 CHOYP_TRIADDRAFT_53733.1.1 m.16896 sp MUC4_HUMAN 21.681 452 291 16 16 451 1034 1438 3.10E-13 77 MUC4_HUMAN reviewed Mucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)] MUC4 Homo sapiens (Human) 2169 cell-matrix adhesion [GO:0007160]; maintenance of gastrointestinal epithelium [GO:0030277]; O-glycan processing [GO:0016266] GO:0005176; GO:0005578; GO:0005615; GO:0005796; GO:0005887; GO:0007160; GO:0016020; GO:0016266; GO:0030197; GO:0030277; GO:0031982; GO:0070062 0 0 0 PF06119;PF00094; Q9ESN4 CHOYP_C1QL2.10.32 m.5706 sp C1QL3_MOUSE 30.435 115 73 2 215 326 143 253 3.10E-07 54.3 C1QL3_MOUSE reviewed Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) 255 regulation of synapse organization [GO:0050807] GO:0005576; GO:0005581; GO:0050807 0 0 0 PF00386;PF01391; Q9U3W6 CHOYP_NEMVEDRAFT_V1G199927.4.9 m.42328 sp MAB21_DROME 24.405 168 115 3 189 350 183 344 3.10E-07 56.6 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; Q9U639 CHOYP_HSP70-3.1.1 m.19152 sp HSP7D_MANSE 86.74 181 24 0 1 181 410 590 3.10E-107 324 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9VCA8 CHOYP_LOC100641396.22.27 m.60246 sp ANKHM_DROME 40.341 176 99 5 3 172 630 805 3.10E-27 110 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9Z0J8 CHOYP_LOC100740523.1.1 m.834 sp NEGR1_RAT 28.412 359 206 15 3 342 15 341 3.10E-30 120 NEGR1_RAT reviewed Neuronal growth regulator 1 (Kindred of IgLON) (Kilon) Negr1 Rattus norvegicus (Rat) 348 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0030425; GO:0031225; GO:0043025 0 0 0 PF07679; A6NNA5 CHOYP_LOC591696.1.1 m.48184 sp DRGX_HUMAN 38.222 225 107 5 79 285 10 220 3.11E-31 120 DRGX_HUMAN reviewed Dorsal root ganglia homeobox protein (Paired-related homeobox protein-like 1) DRGX PRRXL1 Homo sapiens (Human) 263 "axon guidance [GO:0007411]; detection of chemical stimulus [GO:0009593]; detection of temperature stimulus [GO:0016048]; dorsal spinal cord development [GO:0021516]; neuron migration [GO:0001764]; regulation of transcription, DNA-templated [GO:0006355]; sensory perception of mechanical stimulus [GO:0050954]; transcription, DNA-templated [GO:0006351]; trigeminal nerve development [GO:0021559]" GO:0001764; GO:0005634; GO:0006351; GO:0006355; GO:0007411; GO:0009593; GO:0016048; GO:0021516; GO:0021559; GO:0043565; GO:0050954 0 0 0 PF00046;PF03826; O96006 CHOYP_ZBED4.1.1 m.48856 sp ZBED1_HUMAN 23.054 668 432 20 37 659 20 650 3.11E-28 124 ZBED1_HUMAN reviewed Zinc finger BED domain-containing protein 1 (Putative Ac-like transposable element) (dREF homolog) ZBED1 ALTE DREF KIAA0785 TRAMP Homo sapiens (Human) 694 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000228; GO:0000977; GO:0003700; GO:0004803; GO:0005634; GO:0005737; GO:0006357; GO:0015629; GO:0046872 0 0 0 PF05699;PF02892; P01040 CHOYP_contig_024271 m.27553 sp CYTA_HUMAN 34.615 78 45 2 22 99 2 73 3.11E-06 45.4 CYTA_HUMAN reviewed "Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]" CSTA STF1 STFA Homo sapiens (Human) 98 keratinocyte differentiation [GO:0030216]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; peptide cross-linking [GO:0018149]; single organismal cell-cell adhesion [GO:0016337] GO:0001533; GO:0002020; GO:0004869; GO:0005198; GO:0005615; GO:0005634; GO:0005737; GO:0010466; GO:0016337; GO:0018149; GO:0030216; GO:0030674; GO:0031012; GO:0045861; GO:0070062 0 0 0 PF00031; P0C2B8 CHOYP_MRPL55.1.1 m.1120 sp RM55_BOVIN 43.75 96 53 1 17 111 30 125 3.11E-20 82.4 RM55_BOVIN reviewed "39S ribosomal protein L55, mitochondrial (L55mt) (MRP-L55)" MRPL55 Bos taurus (Bovine) 126 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124]; translation [GO:0006412] GO:0003735; GO:0005743; GO:0005762; GO:0006412; GO:0070124; GO:0070125 0 0 0 PF09776; P11276 CHOYP_LOC577931.1.3 m.13388 sp FINC_MOUSE 21.943 597 365 17 1359 1904 1521 2067 3.11E-12 77 FINC_MOUSE reviewed Fibronectin (FN) [Cleaved into: Anastellin] Fn1 Mus musculus (Mouse) 2477 "acute-phase response [GO:0006953]; angiogenesis [GO:0001525]; calcium-independent cell-matrix adhesion [GO:0007161]; cell activation [GO:0001775]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell-substrate junction assembly [GO:0007044]; cellular response to BMP stimulus [GO:0071773]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mercury ion [GO:0071288]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; glial cell migration [GO:0008347]; integrin activation [GO:0033622]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transforming growth factor-beta secretion [GO:2001202]; peptide cross-linking [GO:0018149]; positive regulation of axon extension [GO:0045773]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; regulation of cell shape [GO:0008360]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of protein phosphorylation [GO:0001932]; response to glucocorticoid [GO:0051384]; response to ischemia [GO:0002931]; response to ozone [GO:0010193]; substrate adhesion-dependent cell spreading [GO:0034446]; wound healing [GO:0042060]" GO:0001525; GO:0001775; GO:0001932; GO:0002020; GO:0002931; GO:0005178; GO:0005577; GO:0005578; GO:0005604; GO:0005605; GO:0005615; GO:0005793; GO:0006953; GO:0007044; GO:0007155; GO:0007160; GO:0007161; GO:0008201; GO:0008284; GO:0008347; GO:0008360; GO:0010193; GO:0010628; GO:0016324; GO:0016504; GO:0018149; GO:0030198; GO:0031012; GO:0033622; GO:0034446; GO:0035924; GO:0035987; GO:0036120; GO:0042060; GO:0042802; GO:0043066; GO:0045340; GO:0045773; GO:0048146; GO:0050921; GO:0051384; GO:0070062; GO:0070372; GO:0071222; GO:0071288; GO:0071333; GO:0071347; GO:0071380; GO:0071560; GO:0071773; GO:0072562; GO:1904237; GO:2001202 0 0 cd00062; PF00039;PF00040;PF00041; P11799 CHOYP_TVAG_272650.1.1 m.43484 sp MYLK_CHICK 44 75 42 0 2 76 34 108 3.11E-12 73.6 MYLK_CHICK reviewed "Myosin light chain kinase, smooth muscle (MLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" Mylk Gallus gallus (Chicken) 1906 positive regulation of cell migration [GO:0030335]; smooth muscle contraction [GO:0006939] GO:0004687; GO:0005524; GO:0005829; GO:0006939; GO:0016020; GO:0030335; GO:0046872 0 0 0 PF00041;PF07679;PF00069; P18503 CHOYP_BRAFLDRAFT_76550.5.21 m.45558 sp CAS4_EPHMU 31.967 122 69 3 112 233 206 313 3.11E-06 51.6 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P42577 CHOYP_LOC100371852.1.1 m.22629 sp FRIS_LYMST 74.419 129 30 2 8 136 34 159 3.11E-64 196 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; Q06852 CHOYP_NEMVEDRAFT_V1G208691.10.10 m.53085 sp SLAP1_CLOTH 59.722 144 41 10 8 135 1512 1654 3.11E-08 56.6 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q08705 CHOYP_ISCW_ISCW012049.1.1 m.30296 sp CTCF_CHICK 62.121 198 73 2 100 295 266 463 3.11E-77 253 CTCF_CHICK reviewed Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) CTCF Gallus gallus (Chicken) 728 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q2EI21 CHOYP_BRAFLDRAFT_141143.1.1 m.61742 sp RESTA_XENLA 33.582 134 72 4 81 201 1146 1275 3.11E-06 52.8 RESTA_XENLA reviewed RE1-silencing transcription factor A (Neural-restrictive silencer factor A) rest-a nrsf-a Xenopus laevis (African clawed frog) 1501 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0046872 0 0 0 0 Q3TV65 CHOYP_BRAFLDRAFT_221394.1.1 m.66239 sp MPND_MOUSE 50.607 247 122 0 271 517 224 470 3.11E-83 270 MPND_MOUSE reviewed MPN domain-containing protein (EC 3.4.-.-) Mpnd Mus musculus (Mouse) 487 0 GO:0008233 0 0 0 PF01398; Q3U515 CHOYP_SCE4104.1.2 m.44224 sp VWCE_MOUSE 23.301 309 149 13 1 236 315 608 3.11E-07 54.3 VWCE_MOUSE reviewed von Willebrand factor C and EGF domain-containing protein Vwce Mus musculus (Mouse) 929 positive regulation of cell proliferation [GO:0008284]; regulation of signal transduction [GO:0009966] GO:0005509; GO:0005576; GO:0008284; GO:0009966 0 0 0 PF07645;PF00093; Q4QQM4 CHOYP_LOC755950.1.1 m.26092 sp P5I11_MOUSE 41.143 175 97 4 8 176 11 185 3.11E-36 128 P5I11_MOUSE reviewed Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) 189 0 GO:0016021 0 0 0 PF14936; Q5BJP5 CHOYP_RL3.3.7 m.33542 sp TM230_RAT 63.866 119 40 1 35 150 1 119 3.11E-45 147 TM230_RAT reviewed Transmembrane protein 230 Tmem230 Rattus norvegicus (Rat) 120 0 GO:0016021 0 0 0 PF05915; Q5EAR5 CHOYP_DHTK1.1.1 m.8425 sp TRPT1_DANRE 50.732 205 94 4 195 395 23 224 3.11E-62 211 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q5RK00 CHOYP_LOC100379027.1.1 m.27022 sp RM46_RAT 33.871 248 155 4 29 276 24 262 3.11E-38 139 RM46_RAT reviewed "39S ribosomal protein L46, mitochondrial (L46mt) (MRP-L46)" Mrpl46 Rattus norvegicus (Rat) 277 0 GO:0003735; GO:0005654; GO:0005762; GO:0016787; GO:0030054 0 0 cd04661; PF11788; Q5XII5 CHOYP_LOC100370874.1.1 m.429 sp WAP53_RAT 47.075 359 170 7 173 517 153 505 3.11E-108 335 WAP53_RAT reviewed Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD repeat-containing protein WRAP53) (WD40 repeat-containing protein antisense to TP53 gene) Wrap53 Tcab1 Wdr79 Rattus norvegicus (Rat) 532 positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; telomere formation via telomerase [GO:0032203] GO:0003723; GO:0005697; GO:0005737; GO:0015030; GO:0032203; GO:0032212; GO:0051973; GO:0070034 0 0 0 PF00400; Q62158 CHOYP_TRI27.2.3 m.60199 sp TRI27_MOUSE 27 200 116 7 52 233 86 273 3.11E-08 57 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q67XW5 CHOYP_MYCGRDRAFT_89575.6.12 m.38427 sp UBP18_ARATH 46.774 62 24 2 113 170 52 108 3.11E-06 53.5 UBP18_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (Deubiquitinating enzyme 18) (AtUBP18) (Ubiquitin thioesterase 18) (Ubiquitin-specific-processing protease 18) UBP18 At4g31670 F28M20.140 Arabidopsis thaliana (Mouse-ear cress) 631 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016021; GO:0016579; GO:0036459; GO:0046872 0 0 0 PF00443;PF01753; Q6DIB5 CHOYP_MEG10.82.91 m.60981 sp MEG10_MOUSE 30.606 330 166 16 4 306 418 711 3.11E-23 103 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q7Z5P9 CHOYP_PF11_0479.1.1 m.752 sp MUC19_HUMAN 35.289 1159 551 59 2 1052 4823 5890 3.11E-18 95.1 MUC19_HUMAN reviewed Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) 8384 O-glycan processing [GO:0016266] GO:0005796; GO:0016266; GO:0070062 0 0 0 PF08742;PF01826;PF00094; Q86UP9 CHOYP_GLNA2.1.4 m.4134 sp LHPL3_HUMAN 42.791 215 120 1 10 221 20 234 3.11E-63 201 LHPL3_HUMAN reviewed Lipoma HMGIC fusion partner-like 3 protein LHFPL3 LHFPL4 Homo sapiens (Human) 236 0 GO:0016021 0 0 0 PF10242; Q8C525 CHOYP_NEMVEDRAFT_V1G218264.1.14 m.2428 sp M21D2_MOUSE 26.174 149 102 4 84 231 181 322 3.11E-08 57.4 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8IWR1 CHOYP_TRIM2.6.59 m.12732 sp TRI59_HUMAN 26.545 275 170 9 91 361 8 254 3.11E-16 83.2 TRI59_HUMAN reviewed Tripartite motif-containing protein 59 (RING finger protein 104) (Tumor suppressor TSBF-1) TRIM59 RNF104 TRIM57 TSBF1 Homo sapiens (Human) 403 cilium assembly [GO:0042384]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124] GO:0005783; GO:0005789; GO:0005813; GO:0005929; GO:0008270; GO:0016021; GO:0030992; GO:0042384; GO:0043124 0 0 0 PF00643;PF13445; Q8IWY8 CHOYP_LOC100678689.1.2 m.22350 sp ZSC29_HUMAN 32.222 90 53 3 57 144 248 331 3.11E-06 52.8 ZSC29_HUMAN reviewed Zinc finger and SCAN domain-containing protein 29 (Zinc finger protein 690) ZSCAN29 ZNF690 Homo sapiens (Human) 852 "transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF02023;PF00096; Q8IYB7 CHOYP_DI3L2.1.1 m.61979 sp DI3L2_HUMAN 45.676 370 178 7 330 677 33 401 3.11E-86 293 DI3L2_HUMAN reviewed DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-) DIS3L2 FAM6A Homo sapiens (Human) 885 "cell division [GO:0051301]; miRNA catabolic process [GO:0010587]; mitotic nuclear division [GO:0007067]; mitotic sister chromatid separation [GO:0051306]; negative regulation of cell proliferation [GO:0008285]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; stem cell population maintenance [GO:0019827]" GO:0000175; GO:0000176; GO:0000177; GO:0000287; GO:0000291; GO:0000932; GO:0004540; GO:0005737; GO:0005844; GO:0006364; GO:0007067; GO:0008266; GO:0008285; GO:0010587; GO:0016075; GO:0019827; GO:0034427; GO:0051301; GO:0051306; GO:1990074 0 0 0 0 Q8TB45 CHOYP_BRAFLDRAFT_125986.1.1 m.2658 sp DPTOR_HUMAN 37.027 370 211 5 19 367 32 400 3.11E-70 229 DPTOR_HUMAN reviewed DEP domain-containing mTOR-interacting protein (DEP domain-containing protein 6) DEPTOR DEPDC6 Homo sapiens (Human) 409 intracellular signal transduction [GO:0035556]; negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; regulation of extrinsic apoptotic signaling pathway [GO:2001236] GO:0005622; GO:0006469; GO:0032007; GO:0035556; GO:0045792; GO:2001236 0 0 0 PF00610; Q91ZT7 CHOYP_TVAG_291980.1.1 m.54145 sp ASB10_MOUSE 32.231 121 78 2 823 943 218 334 3.11E-09 63.9 ASB10_MOUSE reviewed Ankyrin repeat and SOCS box protein 10 (ASB-10) Asb10 Mus musculus (Mouse) 467 intracellular signal transduction [GO:0035556] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0031625; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00023;PF12796;PF07525; Q96MM6 CHOYP_BRAFLDRAFT_208197.9.21 m.36292 sp HS12B_HUMAN 26.822 645 403 14 2 585 47 683 3.11E-79 267 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9D5U8 CHOYP_BRAFLDRAFT_63948.1.1 m.14645 sp CNBD2_MOUSE 34.545 110 71 1 2 110 273 382 3.11E-11 67.8 CNBD2_MOUSE reviewed Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function) Cnbd2 Cris Mus musculus (Mouse) 673 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q9ESN6 CHOYP_BRAFLDRAFT_232970.3.5 m.32673 sp TRIM2_MOUSE 28.333 180 116 7 82 256 536 707 3.11E-08 58.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JHI9 CHOYP_SLC40A1.1.1 m.55100 sp S40A1_MOUSE 36.19 315 159 6 1 312 57 332 3.11E-51 180 S40A1_MOUSE reviewed Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1) Slc40a1 Fpn1 Ireg1 Slc11a3 Slc39a1 Mus musculus (Mouse) 570 cellular iron ion homeostasis [GO:0006879]; endothelium development [GO:0003158]; ferrous iron export [GO:1903988]; iron ion homeostasis [GO:0055072]; iron ion transmembrane transport [GO:0034755]; iron ion transport [GO:0006826]; lymphocyte homeostasis [GO:0002260]; multicellular organismal iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395]; spleen development [GO:0048536]; spleen trabecula formation [GO:0060345] GO:0002260; GO:0003158; GO:0004872; GO:0005381; GO:0005622; GO:0005771; GO:0005886; GO:0006826; GO:0006879; GO:0008021; GO:0015093; GO:0016021; GO:0016323; GO:0017046; GO:0034395; GO:0034755; GO:0043066; GO:0045944; GO:0048536; GO:0055072; GO:0060345; GO:0060586; GO:0097689; GO:1903988 0 0 0 PF06963; Q9UPV9 CHOYP_LOC100647086.1.1 m.27656 sp TRAK1_HUMAN 33.852 257 111 12 2 234 372 593 3.11E-15 78.2 TRAK1_HUMAN reviewed Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) TRAK1 KIAA1042 OIP106 Homo sapiens (Human) 953 endosome to lysosome transport [GO:0008333]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0005634; GO:0005737; GO:0005739; GO:0005769; GO:0006357; GO:0006493; GO:0006605; GO:0008333 0 0 0 PF04849;PF12448; Q9V4M2 CHOYP_BRAFLDRAFT_206799.7.23 m.32437 sp WECH_DROME 32.558 86 55 1 105 187 540 625 3.11E-07 53.9 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; A1L1F6 CHOYP_INO80D.1.1 m.10172 sp I80DB_DANRE 29.602 402 203 10 586 975 309 642 3.12E-34 145 I80DB_DANRE reviewed INO80 complex subunit D-B ino80db zgc:153949 Danio rerio (Zebrafish) (Brachydanio rerio) 843 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006281; GO:0006310; GO:0006351; GO:0006355 0 0 0 PF13891; A2VE47 CHOYP_LOC101160066.1.1 m.65775 sp ADPGK_BOVIN 44.695 443 237 6 31 469 54 492 3.12E-123 371 ADPGK_BOVIN reviewed ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) ADPGK Bos taurus (Bovine) 497 glycolytic process [GO:0006096] GO:0005576; GO:0005783; GO:0006096; GO:0016020; GO:0043843; GO:0046872 PATHWAY: Carbohydrate degradation; glycolysis. {ECO:0000255|PROSITE-ProRule:PRU00584}. 0 0 PF04587; A4IFD7 CHOYP_BRAFLDRAFT_276675.1.1 m.6814 sp ZNT7_BOVIN 61.713 397 117 6 1 383 1 376 3.12E-163 465 ZNT7_BOVIN reviewed Zinc transporter 7 (ZnT-7) (Solute carrier family 30 member 7) SLC30A7 ZNT7 Bos taurus (Bovine) 376 regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043]; sequestering of zinc ion [GO:0032119] GO:0005385; GO:0005794; GO:0010043; GO:0016020; GO:0016021; GO:0016023; GO:0032119; GO:0048471; GO:0061088; GO:0070062 0 0 0 PF01545; B5X5D0 CHOYP_LOC100378844.1.4 m.7322 sp CI116_SALSA 47.674 86 44 1 19 103 29 114 3.12E-25 95.1 CI116_SALSA reviewed UPF0691 protein C9orf116 homolog 0 Salmo salar (Atlantic salmon) 141 0 0 0 0 0 0 O43683 CHOYP_LOC100543305.1.1 m.10790 sp BUB1_HUMAN 27.679 896 542 29 365 1225 234 1058 3.12E-73 269 BUB1_HUMAN reviewed Mitotic checkpoint serine/threonine-protein kinase BUB1 (hBUB1) (EC 2.7.11.1) (BUB1A) BUB1 BUB1L Homo sapiens (Human) 1085 apoptotic process [GO:0006915]; cell division [GO:0051301]; cell proliferation [GO:0008283]; mitotic cell cycle checkpoint [GO:0007093]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; regulation of chromosome segregation [GO:0051983]; regulation of sister chromatid cohesion [GO:0007063]; sister chromatid cohesion [GO:0007062]; spindle assembly checkpoint [GO:0071173]; viral process [GO:0016032] GO:0000776; GO:0000777; GO:0000942; GO:0004672; GO:0004674; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0006915; GO:0007062; GO:0007063; GO:0007067; GO:0007093; GO:0007094; GO:0008283; GO:0016020; GO:0016032; GO:0051301; GO:0051983; GO:0071173 0 0 0 PF08311;PF00069; O70277 CHOYP_BRAFLDRAFT_203307.1.1 m.23867 sp TRIM3_RAT 24.221 289 200 10 265 541 462 743 3.12E-10 66.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_87294.4.6 m.57483 sp TRIM3_RAT 30.769 104 72 0 73 176 500 603 3.12E-09 58.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O94826 CHOYP_TOMM70A.1.1 m.42370 sp TOM70_HUMAN 44 575 296 8 180 736 42 608 3.12E-155 467 TOM70_HUMAN reviewed Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) TOMM70 KIAA0719 TOM70 TOMM70A Homo sapiens (Human) 608 macroautophagy [GO:0016236]; protein targeting to mitochondrion [GO:0006626] GO:0005739; GO:0005741; GO:0005742; GO:0006626; GO:0008320; GO:0016020; GO:0016021; GO:0016236; GO:0070062 0 0 0 PF00515;PF13181; P29240 CHOYP_TRIADDRAFT_31844.1.1 m.31659 sp 5NTD_DIPOM 42.726 543 288 12 20 555 27 553 3.12E-141 424 5NTD_DIPOM reviewed 5'-nucleotidase (EC 3.1.3.5) (Ecto-nucleotidase) 0 Diplobatis ommata (Ocellated electric ray) (Discopyge ommata) 577 nucleotide catabolic process [GO:0009166] GO:0000166; GO:0005886; GO:0008253; GO:0009166; GO:0031225; GO:0046872 0 0 0 PF02872;PF00149; P30841 CHOYP_BRAFLDRAFT_119616.1.1 m.31670 sp CROM_ENTDO 63.277 177 65 0 1 177 1 177 3.12E-76 239 CROM_ENTDO reviewed Omega-crystallin 0 Enteroctopus dofleini (Giant octopus) (Octopus dofleini) 496 0 GO:0005212; GO:0016620 0 0 0 PF00171; P41366 CHOYP_LOC100568041.1.1 m.19021 sp VMO1_CHICK 40 200 94 10 4 200 7 183 3.12E-37 130 VMO1_CHICK reviewed Vitelline membrane outer layer protein 1 (VMO-1) (VMO-I) (VMOI) VMO1 Gallus gallus (Chicken) 183 0 GO:0070062 0 0 0 PF03762; P55266 CHOYP_BRAFLDRAFT_124903.1.1 m.8374 sp DSRAD_RAT 29.592 588 349 18 79 621 596 1163 3.12E-59 218 DSRAD_RAT reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) Adar Dsrad Rattus norvegicus (Rat) 1175 "adenosine to inosine editing [GO:0006382]; defense response to virus [GO:0051607]; gene silencing by RNA [GO:0031047]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; positive regulation of viral genome replication [GO:0045070]; regulation of transcription, DNA-templated [GO:0006355]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0003726; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0006382; GO:0006397; GO:0009615; GO:0016607; GO:0031047; GO:0035455; GO:0044387; GO:0044530; GO:0045070; GO:0045087; GO:0046872; GO:0051607 0 0 0 PF02137;PF00035;PF02295; P58397 CHOYP_LOC100744478.1.1 m.20294 sp ATS12_HUMAN 33.178 214 110 11 110 312 340 531 3.12E-19 97.4 ATS12_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-) ADAMTS12 UNQ1918/PRO4389 Homo sapiens (Human) 1594 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of cellular response to hepatocyte growth factor stimulus [GO:2001113]; negative regulation of cellular response to vascular endothelial growth factor stimulus [GO:1902548]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of hepatocyte growth factor receptor signaling pathway [GO:1902203]; proteoglycan catabolic process [GO:0030167]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of endothelial tube morphogenesis [GO:1901509]; regulation of inflammatory response [GO:0050727] GO:0004222; GO:0005578; GO:0007160; GO:0008270; GO:0016477; GO:0030167; GO:0031012; GO:0032331; GO:0050727; GO:0051603; GO:0071347; GO:0071356; GO:0071773; GO:1901509; GO:1902203; GO:1902548; GO:2001113 0 0 0 PF05986;PF01562;PF01421;PF00090; P59105 CHOYP_LOC100379013.1.3 m.40935 sp SLEB_OCEIH 32.051 156 78 7 106 261 147 274 3.12E-09 59.7 SLEB_OCEIH reviewed Spore cortex-lytic enzyme (SCLE) sleB OB1806 Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) 276 cell wall organization [GO:0071555]; spore germination [GO:0009847]; sporulation resulting in formation of a cellular spore [GO:0030435] GO:0009847; GO:0016787; GO:0030435; GO:0071555 0 0 0 PF07486;PF01471; P84339 CHOYP_CALM.23.50 m.31019 sp CALM_AGABI 60.417 144 57 0 1 144 1 144 3.12E-59 183 CALM_AGABI reviewed Calmodulin (CaM) 0 Agaricus bisporus (White button mushroom) 149 0 GO:0005509 0 0 0 PF13499; Q00960 CHOYP_LOC100533244.1.3 m.520 sp NMDE2_RAT 29.79 856 532 25 39 877 40 843 3.12E-109 375 NMDE2_RAT reviewed "Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)" Grin2b Rattus norvegicus (Rat) 1482 action potential [GO:0001508]; associative learning [GO:0008306]; cellular response to amino acid stimulus [GO:0071230]; cellular response to dsRNA [GO:0071359]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lipid [GO:0071396]; cellular response to magnesium starvation [GO:0010350]; cellular response to manganese ion [GO:0071287]; cellular response to organic cyclic compound [GO:0071407]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; memory [GO:0007613]; multicellular organismal response to stress [GO:0033555]; positive regulation of cell death [GO:0010942]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of MAPK cascade [GO:0043408]; response to amine [GO:0014075]; response to amphetamine [GO:0001975]; response to calcium ion [GO:0051592]; response to carbohydrate [GO:0009743]; response to cocaine [GO:0042220]; response to cytokine [GO:0034097]; response to electrical stimulus [GO:0051602]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; response to growth hormone [GO:0060416]; response to magnesium ion [GO:0032026]; response to manganese ion [GO:0010042]; response to mechanical stimulus [GO:0009612]; response to methylmercury [GO:0051597]; response to organic cyclic compound [GO:0014070]; response to other organism [GO:0051707]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511] GO:0001508; GO:0001975; GO:0004970; GO:0004972; GO:0005102; GO:0005149; GO:0005234; GO:0007611; GO:0007613; GO:0007616; GO:0008013; GO:0008144; GO:0008270; GO:0008306; GO:0009612; GO:0009636; GO:0009743; GO:0010042; GO:0010350; GO:0010942; GO:0014049; GO:0014069; GO:0014070; GO:0014075; GO:0017146; GO:0021766; GO:0021987; GO:0030018; GO:0030054; GO:0031749; GO:0032026; GO:0033555; GO:0034097; GO:0035235; GO:0035255; GO:0042165; GO:0042220; GO:0042734; GO:0043005; GO:0043083; GO:0043113; GO:0043195; GO:0043197; GO:0043408; GO:0045202; GO:0045211; GO:0045471; GO:0046982; GO:0048169; GO:0048511; GO:0050806; GO:0050839; GO:0051592; GO:0051597; GO:0051602; GO:0051707; GO:0060416; GO:0060992; GO:0071230; GO:0071287; GO:0071359; GO:0071363; GO:0071396; GO:0071407 0 0 0 PF01094;PF00060;PF10613;PF10565; Q13371 CHOYP_PHLP.1.1 m.25742 sp PHLP_HUMAN 47.727 308 135 7 4 294 3 301 3.12E-90 273 PHLP_HUMAN reviewed Phosducin-like protein (PHLP) PDCL PHLOP1 PhLP1 Homo sapiens (Human) 301 heterotrimeric G-protein complex assembly [GO:1902605]; negative regulation of protein refolding [GO:0061084]; protein folding [GO:0006457]; queuosine biosynthetic process [GO:0008616]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; signal transduction [GO:0007165]; visual perception [GO:0007601] GO:0005057; GO:0005737; GO:0005829; GO:0006457; GO:0007165; GO:0007601; GO:0008277; GO:0008616; GO:0061084; GO:1902605 0 0 0 PF02114; Q29RI9 CHOYP_LOC100371994.1.1 m.50098 sp MAT2B_BOVIN 48.485 297 149 4 13 307 29 323 3.12E-101 303 MAT2B_BOVIN reviewed Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) MAT2B Bos taurus (Bovine) 334 one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556] GO:0005634; GO:0005739; GO:0006556; GO:0006730; GO:0048269; GO:0048270; GO:0070062 PATHWAY: Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1. 0 0 PF04321; Q2KHY5 CHOYP_FAP24.1.1 m.23499 sp FAP24_BOVIN 42.512 207 117 2 17 221 7 213 3.12E-54 176 FAP24_BOVIN reviewed Fanconi anemia core complex-associated protein 24 (Fanconi anemia-associated protein of 24 kDa) FAAP24 Bos taurus (Bovine) 215 DNA repair [GO:0006281] GO:0003677; GO:0006281; GO:0043240 0 0 0 0 Q2KIR1 CHOYP_LOC100377235.2.2 m.41557 sp SNRPA_BOVIN 60.638 282 64 4 39 273 1 282 3.12E-109 320 SNRPA_BOVIN reviewed U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) SNRPA Bos taurus (Bovine) 282 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005654; GO:0005681; GO:0005685; GO:0005730; GO:0005737; GO:0030619; GO:0035614; GO:0044822 0 0 0 PF00076; Q2T9I5 CHOYP_LOC101072128.1.1 m.22011 sp RBM26_XENLA 62.791 86 32 0 2 87 1 86 3.12E-30 118 RBM26_XENLA reviewed RNA-binding protein 26 (RNA-binding motif protein 26) rbm26 Xenopus laevis (African clawed frog) 1059 mRNA processing [GO:0006397]; negative regulation of phosphatase activity [GO:0010923] GO:0000166; GO:0003723; GO:0006397; GO:0010923; GO:0046872 0 0 0 PF01480;PF00076; Q5HZP7 CHOYP_SG196.1.1 m.11096 sp SG196_XENLA 33.333 297 182 8 63 353 55 341 3.12E-47 166 SG196_XENLA reviewed Protein O-mannose kinase (POMK) (EC 2.7.1.-) (Protein kinase-like protein SgK196) (Sugen kinase 196) pomk sgk196 Xenopus laevis (African clawed frog) 352 carbohydrate phosphorylation [GO:0046835]; protein O-linked glycosylation [GO:0006493] GO:0004672; GO:0005524; GO:0005789; GO:0006493; GO:0016021; GO:0016773; GO:0046835 0 0 0 PF07714; Q5VUE5 CHOYP_LOC101277972.1.1 m.61648 sp CA053_HUMAN 39.362 94 51 2 41 130 35 126 3.12E-12 63.2 CA053_HUMAN reviewed Uncharacterized protein C1orf53 C1orf53 Homo sapiens (Human) 145 0 0 0 0 0 0 Q5ZJ56 CHOYP_LOC100208095.1.1 m.22124 sp RL7_CHICK 68.699 246 75 1 10 253 1 246 3.12E-122 350 RL7_CHICK reviewed 60S ribosomal protein L7 RPL7 RCJMB04_20k1 Gallus gallus (Chicken) 246 "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" GO:0000463; GO:0002181; GO:0003735; GO:0022625; GO:0044822 0 0 0 PF00327;PF08079; Q6DFN1 CHOYP_LOC100679620.1.1 m.66367 sp NDUF3_XENTR 35.366 164 95 3 14 174 26 181 3.12E-31 118 NDUF3_XENTR reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 ndufaf3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 183 0 GO:0005634; GO:0005743 0 0 0 PF04430; Q6NRE4 CHOYP_BRAFLDRAFT_88516.1.1 m.8688 sp GARE1_XENLA 56 75 32 1 724 798 802 875 3.12E-17 90.1 GARE1_XENLA reviewed GRB2-associated and regulator of MAPK protein (GRB2-associated and regulator of MAPK1) garem1 fam59a garem Xenopus laevis (African clawed frog) 876 cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0007173; GO:0008284; GO:0051781; GO:0070064; GO:0070374; GO:0071364 0 0 0 PF12736; Q6X862 CHOYP_CAD1.2.2 m.61448 sp PC11X_GORGO 32.905 857 519 21 1 823 12 846 3.12E-117 398 PC11X_GORGO reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) PCDH11X PCDH11 PCDHX Gorilla gorilla gorilla (Western lowland gorilla) 1347 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q8K4L3 CHOYP_SVIL.1.1 m.1139 sp SVIL_MOUSE 40.816 294 159 7 61 346 1245 1531 3.12E-62 218 SVIL_MOUSE reviewed Supervillin (Archvillin) (p205/p250) Svil Mus musculus (Mouse) 2170 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467]; skeletal muscle tissue development [GO:0007519] GO:0002102; GO:0005634; GO:0005737; GO:0005886; GO:0005925; GO:0007010; GO:0007519; GO:0015629; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0043034; GO:0051015; GO:0071437 0 0 0 PF00626;PF02209; Q8N2E2 CHOYP_LOC100199379.1.2 m.59875 sp VWDE_HUMAN 28.71 310 190 8 762 1046 793 1096 3.12E-27 125 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q91WV7 CHOYP_DNJA2.1.2 m.21836 sp SLC31_MOUSE 34.346 428 236 12 35 436 106 514 3.12E-73 246 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q9D2V5 CHOYP_BRAFLDRAFT_260828.1.1 m.16250 sp AAR2_MOUSE 44.924 394 194 2 1 393 6 377 3.12E-128 377 AAR2_MOUSE reviewed Protein AAR2 homolog (AAR2 splicing factor homolog) Aar2 Mus musculus (Mouse) 384 spliceosomal tri-snRNP complex assembly [GO:0000244] GO:0000244 0 0 cd13778;cd13777; PF05282; Q9DAN9 CHOYP_NEMVEDRAFT_V1G240545.2.3 m.50614 sp CQ105_MOUSE 43.011 93 48 2 2 90 56 147 3.12E-13 66.2 CQ105_MOUSE reviewed Uncharacterized protein C17orf105 homolog 0 Mus musculus (Mouse) 164 0 0 0 0 0 PF13879; Q9H7V2 CHOYP_BRAFLDRAFT_119484.2.3 m.60446 sp SYNG1_HUMAN 29.487 78 55 0 46 123 177 254 3.12E-07 50.4 SYNG1_HUMAN reviewed Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B) SYNDIG1 C20orf39 TMEM90B Homo sapiens (Human) 258 intracellular protein transport [GO:0006886]; positive regulation of synapse assembly [GO:0051965]; response to biotic stimulus [GO:0009607]; synaptic vesicle clustering [GO:0097091] GO:0005887; GO:0006886; GO:0009607; GO:0014069; GO:0030054; GO:0031901; GO:0035254; GO:0042803; GO:0043197; GO:0043198; GO:0044297; GO:0045211; GO:0051965; GO:0060076; GO:0097091; GO:0098793 0 0 0 PF04505; Q9JM99 CHOYP_BRAFLDRAFT_268816.1.1 m.17303 sp PRG4_MOUSE 57.143 133 43 12 247 365 475 607 3.12E-10 65.5 PRG4_MOUSE reviewed Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] Prg4 Msf Szp Mus musculus (Mouse) 1054 hematopoietic stem cell proliferation [GO:0071425]; immune response [GO:0006955]; negative regulation of interleukin-6 biosynthetic process [GO:0045409]; regulation of cell proliferation [GO:0042127] GO:0005044; GO:0005615; GO:0006955; GO:0030247; GO:0042127; GO:0045409; GO:0071425 0 0 0 PF00045;PF01033; Q9NUV9 CHOYP_GIMAP4.4.4 m.58504 sp GIMA4_HUMAN 40.467 257 137 4 47 296 16 263 3.12E-60 202 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9P215 CHOYP_BRAFLDRAFT_131216.1.1 m.8823 sp POGK_HUMAN 39.173 411 239 6 6 408 197 604 3.12E-99 312 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9P215 CHOYP_LOC100368470.3.3 m.62149 sp POGK_HUMAN 22.776 281 199 5 5 284 262 525 3.12E-11 67.8 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9QYI4 CHOYP_BRAFLDRAFT_209304.1.2 m.62581 sp DJB12_MOUSE 42.933 375 193 8 10 370 5 372 3.12E-93 286 DJB12_MOUSE reviewed DnaJ homolog subfamily B member 12 (mDj10) Dnajb12 Mus musculus (Mouse) 376 0 GO:0016020; GO:0016021 0 0 cd06257; PF00226;PF09320; Q9R1R2 CHOYP_BRAFLDRAFT_79377.2.30 m.8481 sp TRIM3_MOUSE 28.571 119 80 3 71 185 625 742 3.12E-08 57 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UIF8 CHOYP_BRAFLDRAFT_122791.6.6 m.55912 sp BAZ2B_HUMAN 39.469 565 286 12 550 1091 731 1262 3.12E-104 377 BAZ2B_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00439;PF02791;PF01429;PF00628;PF15613; Q9VRN5 CHOYP_LOC664138.1.1 m.26660 sp LIN28_DROME 60.317 126 50 0 11 136 39 164 3.12E-48 157 LIN28_DROME reviewed Protein lin-28 homolog lin-28 CG17334 Drosophila melanogaster (Fruit fly) 195 "negative regulation of pre-miRNA processing [GO:2000632]; oogenesis [GO:0048477]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of stem cell proliferation [GO:2000648]; regulation of transcription, DNA-templated [GO:0006355]; symmetric stem cell division [GO:0098724]" GO:0003677; GO:0003729; GO:0005737; GO:0006355; GO:0008270; GO:0046628; GO:0048477; GO:0098724; GO:2000632; GO:2000648 0 0 cd04458; PF00313; Q9XUY5 CHOYP_MCM4.1.1 m.61254 sp AT1B3_CAEEL 38.621 290 165 5 29 313 26 307 3.12E-71 226 AT1B3_CAEEL reviewed Probable sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) nkb-3 F55F3.3 Caenorhabditis elegans 317 potassium ion transport [GO:0006813]; sodium ion transport [GO:0006814] GO:0005890; GO:0006813; GO:0006814 0 0 0 PF00287; A9RA96 CHOYP_LOC100136251.1.1 m.58608 sp SPB10_PAPAN 53.571 112 52 0 2 113 286 397 3.13E-37 132 SPB10_PAPAN reviewed Serpin B10 SERPINB10 Papio anubis (Olive baboon) 397 0 GO:0004867; GO:0005615; GO:0005634; GO:0005737 0 0 0 PF00079; D2GXS7 CHOYP_contig_000670 m.666 sp TRIM2_AILME 24.157 178 115 4 106 276 492 656 3.13E-07 55.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O70352 CHOYP_CD82.2.3 m.17728 sp CD82_RAT 31.429 245 151 7 24 260 24 259 3.13E-37 135 CD82_RAT reviewed CD82 antigen (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82) Cd82 Kai1 Rattus norvegicus (Rat) 266 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; P02552 CHOYP_TBA3E.1.1 m.4875 sp TBA1_CHICK 88.66 97 10 1 20 116 186 281 3.13E-56 182 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P06603 CHOYP_TBA1A.3.4 m.25623 sp TBA1_DROME 98.225 169 3 0 1 169 160 328 3.13E-120 355 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P06868 CHOYP_PLMN.6.11 m.35554 sp PLMN_BOVIN 49.102 167 64 4 95 243 196 359 3.13E-43 158 PLMN_BOVIN reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; response to heat [GO:0009408]; tissue remodeling [GO:0048771] GO:0004252; GO:0005102; GO:0005576; GO:0007596; GO:0009408; GO:0019904; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P25107 CHOYP_LOC100175770.1.1 m.48136 sp PTH1R_DIDVI 39.456 441 249 7 52 480 90 524 3.13E-96 306 PTH1R_DIDVI reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) 585 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166] GO:0004991; GO:0005887; GO:0007166; GO:0007188; GO:0017046; GO:0043621 0 0 0 PF00002;PF02793; P43679 CHOYP_ACHA6.4.4 m.66134 sp ACHB3_CHICK 30.088 452 270 11 40 466 1 431 3.13E-66 223 ACHB3_CHICK reviewed Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Gallus gallus (Chicken) 455 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P50225 CHOYP_ST1B1.3.4 m.43679 sp ST1A1_HUMAN 31.429 280 165 6 20 278 19 292 3.13E-45 157 ST1A1_HUMAN reviewed Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST) SULT1A1 STP STP1 OK/SW-cl.88 Homo sapiens (Human) 295 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; estrogen metabolic process [GO:0008210]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005829; GO:0006584; GO:0006805; GO:0008146; GO:0008202; GO:0008210; GO:0009308; GO:0009812; GO:0047894; GO:0050294; GO:0050427; GO:0051923 0 0 0 PF00685; P57756 CHOYP_ANGP4.3.7 m.24608 sp FCN2_RAT 48.588 177 85 4 364 537 116 289 3.13E-45 164 FCN2_RAT reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Rattus norvegicus (Rat) 319 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0033691; GO:0046872 0 0 0 PF01391;PF00147; P58421 CHOYP_LOC100313610.1.2 m.9570 sp FZD5_XENLA 66.488 373 112 4 6 367 189 559 3.13E-177 507 FZD5_XENLA reviewed Frizzled-5 (Fz-5) (Xfz5) fzd5 fz5 Xenopus laevis (African clawed frog) 559 camera-type eye development [GO:0043010]; neuron development [GO:0048666]; regulation of cell differentiation [GO:0045595]; regulation of cell proliferation [GO:0042127] GO:0004930; GO:0005886; GO:0016021; GO:0042127; GO:0042813; GO:0043010; GO:0045595; GO:0048666 0 0 0 PF01534;PF01392; P97527 CHOYP_CNTN5.1.5 m.1741 sp CNTN5_RAT 28.421 190 116 9 5 186 344 521 3.13E-10 62 CNTN5_RAT reviewed Contactin-5 (Neural recognition molecule NB-2) Cntn5 Rattus norvegicus (Rat) 1099 cell adhesion [GO:0007155]; sensory perception of sound [GO:0007605] GO:0005886; GO:0007155; GO:0007605; GO:0031225 0 0 0 PF00041;PF07679; Q0P5A1 CHOYP_CADM4.1.1 m.60662 sp DCTN3_BOVIN 37.43 179 103 2 9 187 10 179 3.13E-38 132 DCTN3_BOVIN reviewed Dynactin subunit 3 DCTN3 Bos taurus (Bovine) 186 cytokinesis [GO:0000910]; microtubule-based process [GO:0007017]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0000910; GO:0005813; GO:0005819; GO:0005869; GO:0007017; GO:0007067; GO:0030496; GO:0032154; GO:0048471 0 0 0 PF07426; Q14162 CHOYP_MEG11.15.25 m.46952 sp SREC_HUMAN 31.481 270 126 11 210 462 119 346 3.13E-20 97.4 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q56K03 CHOYP_LOC100533291.3.7 m.23010 sp RL27A_BOVIN 76.812 138 31 1 17 153 1 138 3.13E-73 219 RL27A_BOVIN reviewed 60S ribosomal protein L27a RPL27A Bos taurus (Bovine) 148 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00828; Q5BJP5 CHOYP_LOC586039.1.1 m.27102 sp TM230_RAT 64.706 119 39 1 1 116 1 119 3.13E-46 147 TM230_RAT reviewed Transmembrane protein 230 Tmem230 Rattus norvegicus (Rat) 120 0 GO:0016021 0 0 0 PF05915; Q5BLE8 CHOYP_BRAFLDRAFT_119025.3.3 m.26496 sp RETST_DANRE 40.932 601 346 5 21 620 10 602 3.13E-171 503 RETST_DANRE reviewed "Putative all-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat)" retsat zgc:113107 Danio rerio (Zebrafish) (Brachydanio rerio) 607 0 GO:0016020; GO:0051786 0 0 0 PF01593; Q5T7P8 CHOYP_LOC100376714.3.3 m.62680 sp SYT6_HUMAN 37.766 188 107 6 123 305 203 385 3.13E-32 127 SYT6_HUMAN reviewed Synaptotagmin-6 (Synaptotagmin VI) (SytVI) SYT6 Homo sapiens (Human) 510 acrosomal vesicle exocytosis [GO:0060478]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; regulation of calcium ion-dependent exocytosis [GO:0017158]; vesicle fusion [GO:0006906] GO:0005509; GO:0005829; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019898; GO:0019905; GO:0030054; GO:0030276; GO:0030672; GO:0042803; GO:0048791; GO:0060478; GO:0070382; GO:0097038 0 0 0 PF00168; Q5ZQU0 CHOYP_LOC580675.1.1 m.44042 sp SNED1_RAT 35.398 113 72 1 93 205 680 791 3.13E-17 87.8 SNED1_RAT reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" Sned1 Rattus norvegicus (Rat) 1403 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00008;PF00041;PF12661;PF06119; Q61035 CHOYP_LOC100695771.1.1 m.40143 sp SYHC_MOUSE 70.118 338 101 0 16 353 3 340 3.13E-178 507 SYHC_MOUSE reviewed "Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)" Hars Mus musculus (Mouse) 509 histidyl-tRNA aminoacylation [GO:0006427]; mitochondrial translation [GO:0032543] GO:0004821; GO:0005524; GO:0005737; GO:0005739; GO:0006427; GO:0032543 0 0 cd00859; PF03129;PF00458; Q62904 CHOYP_DHB7.1.1 m.26648 sp DHB7_RAT 47.022 319 160 4 19 336 4 314 3.13E-105 315 DHB7_RAT reviewed 3-keto-steroid reductase (EC 1.1.1.270) (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (PRL receptor-associated protein) (PRAP) Hsd17b7 Rattus norvegicus (Rat) 334 estrogen biosynthetic process [GO:0006703]; hippocampus development [GO:0021766]; maternal process involved in female pregnancy [GO:0060135]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to organic cyclic compound [GO:0014070]; response to prolactin [GO:1990637]; steroid biosynthetic process [GO:0006694] GO:0000253; GO:0004303; GO:0005148; GO:0005886; GO:0006694; GO:0006703; GO:0014070; GO:0016020; GO:0016021; GO:0021766; GO:0032355; GO:0042493; GO:0060135; GO:1990637 PATHWAY: Steroid biosynthesis; estrogen biosynthesis.; PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. 0 0 PF00106; Q6V0I7 CHOYP_LOC100374832.2.5 m.13470 sp FAT4_HUMAN 38.961 77 37 2 3853 3919 3810 3886 3.13E-08 64.3 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q7Z4H7 CHOYP_TRIADDRAFT_54602.1.1 m.6694 sp HAUS6_HUMAN 27.34 406 255 10 37 437 44 414 3.13E-34 145 HAUS6_HUMAN reviewed HAUS augmin-like complex subunit 6 HAUS6 DGT6 FAM29A KIAA1574 Homo sapiens (Human) 955 cell division [GO:0051301]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0000086; GO:0005654; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005829; GO:0005874; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 PF14661; Q7ZU13 CHOYP_LOC100565194.1.1 m.4946 sp SPNS1_DANRE 55.134 448 179 4 57 492 42 479 3.13E-168 488 SPNS1_DANRE reviewed Protein spinster homolog 1 (Protein not really started) (Spinster-like protein) spns1 nrs spinl Danio rerio (Zebrafish) (Brachydanio rerio) 506 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cellular senescence [GO:0090398]; locomotion [GO:0040011]; sphingosine-1-phosphate signaling pathway [GO:0003376]; transmembrane transport [GO:0055085] GO:0003376; GO:0005743; GO:0005765; GO:0006914; GO:0016021; GO:0031982; GO:0040011; GO:0046624; GO:0055085; GO:0090398; GO:0097352 0 0 cd06174; PF07690; Q80ZA4 CHOYP_LOC100373890.2.2 m.27941 sp PKHL1_MOUSE 31.761 318 209 5 11 327 1324 1634 3.13E-43 162 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q86Z23 CHOYP_SI_DKEY-5N18.1.2.2 m.66536 sp C1QL4_HUMAN 33.333 138 80 5 68 197 105 238 3.13E-08 57.4 C1QL4_HUMAN reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8K088 CHOYP_ZBTB6.1.1 m.26045 sp ZBTB6_MOUSE 29.091 165 98 4 570 733 256 402 3.13E-12 72.8 ZBTB6_MOUSE reviewed Zinc finger and BTB domain-containing protein 6 (Zinc finger protein 482) Zbtb6 Zfp482 Znf482 Mus musculus (Mouse) 423 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF00096; Q96MM6 CHOYP_BRAFLDRAFT_208197.14.21 m.52409 sp HS12B_HUMAN 35.016 634 341 16 5 577 61 684 3.13E-116 363 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9UJ71 CHOYP_CLC4M.1.2 m.34943 sp CLC4K_HUMAN 30.247 162 101 5 47 202 166 321 3.13E-14 73.2 CLC4K_HUMAN reviewed C-type lectin domain family 4 member K (Langerin) (CD antigen CD207) CD207 CLEC4K Homo sapiens (Human) 328 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; defense response to virus [GO:0051607]; receptor-mediated endocytosis [GO:0006898]" GO:0002479; GO:0005537; GO:0005886; GO:0006898; GO:0016021; GO:0030139; GO:0030246; GO:0030669; GO:0031901; GO:0051607 0 0 0 PF00059; Q9UTA8 CHOYP_YL8A.1.1 m.29604 sp YL8A_SCHPO 33.209 268 163 7 29 296 1 252 3.13E-34 128 YL8A_SCHPO reviewed Uncharacterized methyltransferase-like C25B8.10 (EC 2.1.1.-) SPAC25B8.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 256 methylation [GO:0032259] GO:0005634; GO:0005737; GO:0005829; GO:0008757; GO:0032259 0 0 0 PF08241; A7S6M8 CHOYP_LOC100377128.1.1 m.3306 sp LTOR4_NEMVE 42.857 84 48 0 29 112 7 90 3.14E-18 76.6 LTOR4_NEMVE reviewed Ragulator complex protein LAMTOR4 homolog (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) v1g232793 Nematostella vectensis (Starlet sea anemone) 95 cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361] GO:0005764; GO:0008361; GO:0032008; GO:0043547; GO:0061462; GO:0071230; GO:0071986 0 0 0 0 A8E7G4 CHOYP_BRAFLDRAFT_224716.2.2 m.47646 sp FA45A_DANRE 46.457 254 132 2 59 312 100 349 3.14E-79 247 FA45A_DANRE reviewed Protein FAM45A (Protein FAM45) fam45a fam45 si:ch211-117n7.2 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 0 0 0 0 0 B4PN49 CHOYP_BRAFLDRAFT_117283.1.2 m.27753 sp HH_DROYA 30.065 153 63 3 526 678 120 228 3.14E-08 61.6 HH_DROYA reviewed Protein hedgehog [Cleaved into: Protein hedgehog N-product; Protein hedgehog C-product] hh GE23980 Drosophila yakuba (Fruit fly) 465 anatomical structure morphogenesis [GO:0009653]; cell-cell signaling involved in cell fate commitment [GO:0045168]; intein-mediated protein splicing [GO:0016539]; segment polarity determination [GO:0007367] GO:0005615; GO:0005634; GO:0005737; GO:0005886; GO:0007367; GO:0008233; GO:0009653; GO:0016015; GO:0016539; GO:0045168; GO:0046872 0 0 0 PF01085;PF01079; H2A0M0 CHOYP_TVAG_106580.1.1 m.44429 sp NRP_PINMG 28.829 222 140 9 1381 1594 468 679 3.14E-14 81.6 NRP_PINMG reviewed Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 686 0 GO:0005576 0 0 0 0 O17320 CHOYP_PAN2.1.1 m.44694 sp ACT_CRAGI 96.296 81 3 0 27 107 1 81 3.14E-52 171 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P70227 CHOYP_LOC100375107.1.4 m.8458 sp ITPR3_MOUSE 21.692 1489 921 44 1 1306 4 1430 3.14E-66 254 ITPR3_MOUSE reviewed "Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)" Itpr3 Mus musculus (Mouse) 2670 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cellular response to cAMP [GO:0071320]; G-protein coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917] GO:0000822; GO:0005220; GO:0005509; GO:0005634; GO:0005640; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005829; GO:0005886; GO:0005887; GO:0006816; GO:0007186; GO:0007613; GO:0015278; GO:0016020; GO:0030425; GO:0035091; GO:0043025; GO:0043209; GO:0043235; GO:0043533; GO:0048471; GO:0050913; GO:0050916; GO:0050917; GO:0051260; GO:0051291; GO:0051592; GO:0060291; GO:0060402; GO:0070679; GO:0071320 0 0 0 PF08709;PF00520;PF02815;PF08454;PF01365; P85120 CHOYP_TVAG_007510.2.2 m.64163 sp DAPLE_XENLA 23.903 661 376 24 85 706 596 1168 3.14E-07 58.5 DAPLE_XENLA reviewed Daple-like protein (Coiled-coil domain-containing protein 88C-like) (Dvl-associating protein with a high frequency of leucine residues-like) (xDal) ccdc88c dal Xenopus laevis (African clawed frog) 2058 "activation of JUN kinase activity [GO:0007257]; canonical Wnt signaling pathway [GO:0060070]; dorsal/ventral axis specification [GO:0009950]; establishment of planar polarity [GO:0001736]; stress-activated protein kinase signaling cascade [GO:0031098]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0001736; GO:0005737; GO:0007257; GO:0009950; GO:0030165; GO:0031098; GO:0060070; GO:0060071 0 0 0 PF05622; P90702 CHOYP_RL44.1.2 m.28788 sp RL44_BRUMA 58.333 96 38 2 1 96 1 94 3.14E-28 107 RL44_BRUMA reviewed 60S ribosomal protein L44 rpl-44 Brugia malayi (Filarial nematode worm) 105 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00935; Q0KHY3 CHOYP_LOC574757.4.9 m.32027 sp MESH_DROME 26.643 1111 633 44 23 1022 181 1220 3.14E-73 269 MESH_DROME reviewed Protein mesh mesh CG31004 Drosophila melanogaster (Fruit fly) 1454 cell-matrix adhesion [GO:0007160]; multicellular organism development [GO:0007275]; smooth septate junction assembly [GO:0090528] GO:0005920; GO:0007160; GO:0007275; GO:0016021; GO:0016327; GO:0090528 0 0 0 PF03782;PF06119;PF00084;PF00094; Q0VA16 CHOYP_MEF2A.1.1 m.21732 sp WDR70_XENTR 63.725 204 72 2 1 204 169 370 3.14E-91 283 WDR70_XENTR reviewed WD repeat-containing protein 70 wdr70 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 622 0 0 0 0 0 PF00400; Q27HK4 CHOYP_MTX1.1.1 m.43691 sp MTX1_PIG 39.933 298 166 4 20 312 6 295 3.14E-67 216 MTX1_PIG reviewed Metaxin-1 (Mitochondrial outer membrane import complex protein 1) MTX1 Sus scrofa (Pig) 317 protein targeting to mitochondrion [GO:0006626] GO:0005741; GO:0006626; GO:0016021 0 0 0 PF17171;PF10568; Q3U515 CHOYP_KCP.10.13 m.44423 sp VWCE_MOUSE 27.556 450 211 26 13 367 333 762 3.14E-16 84.3 VWCE_MOUSE reviewed von Willebrand factor C and EGF domain-containing protein Vwce Mus musculus (Mouse) 929 positive regulation of cell proliferation [GO:0008284]; regulation of signal transduction [GO:0009966] GO:0005509; GO:0005576; GO:0008284; GO:0009966 0 0 0 PF07645;PF00093; Q5ZLS7 CHOYP_LOC100877728.1.1 m.19879 sp GLYR1_CHICK 39.099 555 298 12 200 730 12 550 3.14E-115 361 GLYR1_CHICK reviewed Putative oxidoreductase GLYR1 (EC 1.-.-.-) (Glyoxylate reductase 1 homolog) (Nuclear protein NP60) GLYR1 NP60 RCJMB04_4p18 Gallus gallus (Chicken) 553 0 GO:0003677; GO:0004616; GO:0005634; GO:0035064; GO:0051287 0 0 0 PF14833;PF03446;PF00855; Q60847 CHOYP_CO6A5.3.6 m.13265 sp COCA1_MOUSE 37.436 195 115 4 7 197 1185 1376 3.14E-28 124 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q6AYR9 CHOYP_LOC576118.1.1 m.34899 sp TSN1_RAT 25.292 257 164 7 8 261 5 236 3.14E-14 73.6 TSN1_RAT reviewed Tetraspanin-1 (Tspan-1) Tspan1 Rattus norvegicus (Rat) 241 cell migration [GO:0016477]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of endocytosis [GO:0045807]; protein stabilization [GO:0050821] GO:0005765; GO:0005887; GO:0007166; GO:0008283; GO:0016477; GO:0045807; GO:0048471; GO:0050821; GO:0070062 0 0 0 PF00335; Q8TDB6 CHOYP_PAR14.7.17 m.34741 sp DTX3L_HUMAN 52.273 176 83 1 1171 1346 556 730 3.14E-49 191 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8WV16 CHOYP_LOC100413574.1.1 m.19502 sp DCAF4_HUMAN 30.275 109 74 1 49 157 6 112 3.14E-09 58.5 DCAF4_HUMAN reviewed DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A) DCAF4 WDR21 WDR21A Homo sapiens (Human) 495 protein ubiquitination [GO:0016567] GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q96JP0 CHOYP_AGAP_AGAP004499.1.1 m.13546 sp FEM1C_HUMAN 35.397 630 380 10 54 674 5 616 3.14E-120 375 FEM1C_HUMAN reviewed Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) 617 protein ubiquitination [GO:0016567] GO:0005654; GO:0005737; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q99081 CHOYP_HTF4.5.5 m.60653 sp HTF4_HUMAN 40.588 510 187 21 262 727 220 657 3.14E-69 245 HTF4_HUMAN reviewed Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) TCF12 BHLHB20 HEB HTF4 Homo sapiens (Human) 682 immune response [GO:0006955]; muscle organ development [GO:0007517]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000790; GO:0000978; GO:0001077; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0006955; GO:0007517; GO:0008134; GO:0035326; GO:0035497; GO:0042803; GO:0043425; GO:0045666; GO:0045944; GO:0046332; GO:0046982; GO:0070888; GO:0090575 0 0 0 PF00010; Q9JM99 CHOYP_LOAG_05558.1.1 m.9152 sp PRG4_MOUSE 52.857 140 46 11 218 341 447 582 3.14E-10 65.1 PRG4_MOUSE reviewed Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] Prg4 Msf Szp Mus musculus (Mouse) 1054 hematopoietic stem cell proliferation [GO:0071425]; immune response [GO:0006955]; negative regulation of interleukin-6 biosynthetic process [GO:0045409]; regulation of cell proliferation [GO:0042127] GO:0005044; GO:0005615; GO:0006955; GO:0030247; GO:0042127; GO:0045409; GO:0071425 0 0 0 PF00045;PF01033; Q9VCA8 CHOYP_LOC593169.1.1 m.3325 sp ANKHM_DROME 32.895 304 190 11 726 1019 550 849 3.14E-27 124 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9W6Y0 CHOYP_MGC89853.4.7 m.26881 sp RS30_ORYLA 72.222 54 15 0 73 126 1 54 3.14E-18 76.3 RS30_ORYLA reviewed 40S ribosomal protein S30 fau rps30 Oryzias latipes (Japanese rice fish) (Japanese killifish) 59 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF04758; Q9WUF3 CHOYP_FUTSC.2.4 m.17517 sp C8AP2_MOUSE 32.258 93 59 1 80 168 55 147 3.14E-06 56.2 C8AP2_MOUSE reviewed CASP8-associated protein 2 (FLICE-associated huge protein) Casp8ap2 Flash Mus musculus (Mouse) 1962 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell cycle [GO:0007049]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; Fas signaling pathway [GO:0036337]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0002020; GO:0003677; GO:0003714; GO:0005634; GO:0005737; GO:0005739; GO:0006351; GO:0006355; GO:0006919; GO:0007049; GO:0008625; GO:0008656; GO:0016605; GO:0032184; GO:0036337; GO:0042802 0 0 0 0 Q9XTQ6 CHOYP_ACDOPBH.3.9 m.16952 sp TBH1_CAEEL 30.061 326 201 8 162 474 271 582 3.14E-35 144 TBH1_CAEEL reviewed Tyramine beta-hydroxylase (EC 1.14.17.-) tbh-1 H13N06.6 Caenorhabditis elegans 657 octopamine biosynthetic process [GO:0006589] GO:0004836; GO:0005507; GO:0006589; GO:0016021; GO:0016715; GO:0045202 0 0 0 PF03712;PF01082;PF03351; A4FUE7 CHOYP_ZC21A.1.3 m.11796 sp ZC21A_BOVIN 54.545 154 69 1 1 154 21 173 3.15E-45 155 ZC21A_BOVIN reviewed Zinc finger C2HC domain-containing protein 1A ZC2HC1A FAM164A Bos taurus (Bovine) 323 0 GO:0046872 0 0 0 0 A4IF63 CHOYP_LOC100374741.69.83 m.56747 sp TRIM2_BOVIN 21.831 142 108 2 432 570 602 743 3.15E-08 60.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2A0L1 CHOYP_TYRO2.1.5 m.10710 sp TYRO2_PINMG 33.333 366 208 13 59 398 55 410 3.15E-40 156 TYRO2_PINMG reviewed Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) 0 Pinctada margaritifera (Black-lipped pearl oyster) 456 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; O24473 CHOYP_CC1G_09497.1.1 m.55998 sp IF2B_WHEAT 38.012 171 106 0 93 263 97 267 3.15E-35 130 IF2B_WHEAT reviewed Eukaryotic translation initiation factor 2 subunit beta (eIF-2-beta) (P38) 0 Triticum aestivum (Wheat) 270 0 GO:0003743; GO:0046872 0 0 0 PF01873; O60218 CHOYP_PHUM_PHUM317840.1.2 m.29476 sp AK1BA_HUMAN 51.634 306 140 5 41 344 3 302 3.15E-96 291 AK1BA_HUMAN reviewed Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) AKR1B10 AKR1B11 Homo sapiens (Human) 316 cellular aldehyde metabolic process [GO:0006081]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202] GO:0001523; GO:0001758; GO:0004033; GO:0005764; GO:0005829; GO:0006081; GO:0007586; GO:0008202; GO:0016488; GO:0044597; GO:0044598; GO:0045550; GO:0047718; GO:0070062 0 0 cd06660; PF00248; P00126 CHOYP_LOC100743548.1.2 m.18991 sp QCR6_BOVIN 44.776 67 35 2 46 112 26 90 3.15E-10 55.5 QCR6_BOVIN reviewed "Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)" UQCRH Bos taurus (Bovine) 91 "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" GO:0005743; GO:0006122; GO:0008121; GO:0070469 0 0 0 PF02320; P08962 CHOYP_AGAP_AGAP004861.1.2 m.43598 sp CD63_HUMAN 28.139 231 128 7 1 229 1 195 3.15E-16 79 CD63_HUMAN reviewed CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) CD63 MLA1 TSPAN30 Homo sapiens (Human) 238 cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cellular protein localization [GO:0034613]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigment granule maturation [GO:0048757]; platelet degranulation [GO:0002576]; positive regulation of cell adhesion [GO:0045785]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of rubidium ion transport [GO:2000680]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0002576; GO:0005615; GO:0005765; GO:0005886; GO:0005887; GO:0007160; GO:0009986; GO:0010008; GO:0010633; GO:0015031; GO:0016477; GO:0030855; GO:0031088; GO:0031226; GO:0031902; GO:0031904; GO:0032585; GO:0034613; GO:0035646; GO:0042470; GO:0043234; GO:0045785; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2000680; GO:2001046 0 0 0 PF00335; P19803 CHOYP_DSEC_GM19691.1.1 m.30070 sp GDIR1_BOVIN 52.174 207 86 3 4 201 2 204 3.15E-70 215 GDIR1_BOVIN reviewed Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha) ARHGDIA Bos taurus (Bovine) 204 regulation of protein localization [GO:0032880]; Rho protein signal transduction [GO:0007266]; semaphorin-plexin signaling pathway [GO:0071526] GO:0001772; GO:0005094; GO:0005096; GO:0005634; GO:0005737; GO:0007266; GO:0032880; GO:0071526 0 0 0 PF02115; P28827 CHOYP_PTPRM.4.15 m.34503 sp PTPRM_HUMAN 32.762 583 361 14 551 1115 880 1449 3.15E-79 288 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P28827 CHOYP_PTPRU.2.2 m.58388 sp PTPRM_HUMAN 33.22 587 353 16 541 1105 880 1449 3.15E-79 288 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P29147 CHOYP_LOC100369711.1.1 m.57992 sp BDH_RAT 37.539 317 184 5 45 357 18 324 3.15E-64 211 BDH_RAT reviewed "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH)" Bdh1 Bdh Rattus norvegicus (Rat) 343 adipose tissue development [GO:0060612]; brain development [GO:0007420]; liver development [GO:0001889]; response to cadmium ion [GO:0046686]; response to corticosterone [GO:0051412]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to growth hormone [GO:0060416]; response to hormone [GO:0009725]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to toxic substance [GO:0009636] GO:0001889; GO:0003858; GO:0005543; GO:0005743; GO:0005759; GO:0007420; GO:0007584; GO:0009636; GO:0009725; GO:0032355; GO:0032868; GO:0042493; GO:0042594; GO:0045471; GO:0046686; GO:0051412; GO:0060416; GO:0060612; GO:0099617 0 0 0 PF00106; P35072 CHOYP_LOC100202983.1.2 m.14939 sp TCB1_CAEBR 32.231 242 154 7 76 313 7 242 3.15E-28 113 TCB1_CAEBR reviewed Transposable element Tcb1 transposase (Transposable element Barney transposase) 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; P41636 CHOYP_BRAFLDRAFT_279625.1.1 m.51890 sp 4CL_PINTA 41.002 539 292 13 52 576 8 534 3.15E-128 389 4CL_PINTA reviewed 4-coumarate--CoA ligase (4CL) (EC 6.2.1.12) (4-coumaroyl-CoA synthase) 4CL Pinus taeda (Loblolly pine) 537 phenylpropanoid metabolic process [GO:0009698] GO:0005524; GO:0009698; GO:0016207 "PATHWAY: Phytoalexin biosynthesis; 3,4',5-trihydroxystilbene biosynthesis; 3,4',5-trihydroxystilbene from trans-4-coumarate: step 1/2." 0 0 PF00501;PF13193; P42573 CHOYP_NEMVEDRAFT_V1G234921.1.1 m.18880 sp CED3_CAEEL 36.713 286 147 11 250 514 224 496 3.15E-34 138 CED3_CAEEL reviewed Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 C48D1.2 Caenorhabditis elegans 503 apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; embryo development ending in birth or egg hatching [GO:0009792]; execution phase of apoptosis [GO:0097194]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; regulation of apoptotic process [GO:0042981]; regulation of cell adhesion [GO:0030155] GO:0004175; GO:0004197; GO:0005737; GO:0006915; GO:0009792; GO:0012501; GO:0016020; GO:0016540; GO:0030155; GO:0030163; GO:0042802; GO:0042981; GO:0048471; GO:0097194; GO:0097200; GO:1902742 0 0 0 PF00619; P70389 CHOYP_CAOG_08239.2.3 m.43888 sp ALS_MOUSE 27.531 563 316 20 51 559 41 565 3.15E-25 114 ALS_MOUSE reviewed Insulin-like growth factor-binding protein complex acid labile subunit (ALS) Igfals Albs Als Mus musculus (Mouse) 603 cell adhesion [GO:0007155] GO:0005520; GO:0005654; GO:0007155; GO:0042567; GO:0070062 0 0 0 PF13855;PF01462; Q3SYZ8 CHOYP_ISCW_ISCW000210.2.4 m.14990 sp PDLI3_BOVIN 50 72 35 1 12 82 11 82 3.15E-12 71.2 PDLI3_BOVIN reviewed PDZ and LIM domain protein 3 PDLIM3 Bos taurus (Bovine) 316 actin filament organization [GO:0007015]; heart development [GO:0007507] GO:0007015; GO:0007507; GO:0008270; GO:0008307; GO:0015629; GO:0030018 0 0 0 PF15936;PF00412;PF00595; Q4FZV0 CHOYP_MANBA.1.2 m.24846 sp MANBA_RAT 35.793 271 127 6 18 283 623 851 3.15E-43 160 MANBA_RAT reviewed Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) Manba Rattus norvegicus (Rat) 881 carbohydrate metabolic process [GO:0005975] GO:0004567; GO:0005537; GO:0005764; GO:0005975 PATHWAY: Glycan metabolism; N-glycan degradation. 0 0 PF02836; Q5JTD7 CHOYP_LRC73.1.1 m.14802 sp LRC73_HUMAN 39.004 241 147 0 1 241 2 242 3.15E-55 187 LRC73_HUMAN reviewed Leucine-rich repeat-containing protein 73 LRRC73 C6orf154 Homo sapiens (Human) 316 0 0 0 0 0 0 Q5T5N4 CHOYP_BRAFLDRAFT_76659.1.1 m.45554 sp CF118_HUMAN 25.87 460 286 14 12 465 41 451 3.15E-22 103 CF118_HUMAN reviewed Uncharacterized protein C6orf118 C6orf118 Homo sapiens (Human) 469 0 0 0 0 0 PF15739; Q5TC84 CHOYP_LOC100633059.1.1 m.20099 sp OGRL1_HUMAN 50 180 90 0 51 230 114 293 3.15E-55 186 OGRL1_HUMAN reviewed Opioid growth factor receptor-like protein 1 OGFRL1 Homo sapiens (Human) 451 0 GO:0004872; GO:0016020 0 0 0 PF04664; Q6AYQ6 CHOYP_LOC100370675.1.1 m.61915 sp MMAD_RAT 40.956 293 146 9 57 328 4 290 3.15E-66 214 MMAD_RAT reviewed "Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial (CblD)" Mmadhc Rattus norvegicus (Rat) 296 cobalamin metabolic process [GO:0009235]; coenzyme biosynthetic process [GO:0009108] GO:0005737; GO:0005739; GO:0009108; GO:0009235 0 0 0 PF10229; Q6DFV8 CHOYP_LOC101068378.1.3 m.2839 sp VWDE_MOUSE 26.556 241 146 8 113 336 405 631 3.15E-14 79.3 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6DRP4 CHOYP_BRAFLDRAFT_110061.1.1 m.5849 sp CCM2_DANRE 28.626 262 139 8 1 222 143 396 3.15E-17 84.3 CCM2_DANRE reviewed Cerebral cavernous malformations protein 2 homolog (Malcavernin) (Valentine) ccm2 vtn Danio rerio (Zebrafish) (Brachydanio rerio) 455 anterior/posterior axis specification [GO:0009948]; cell-cell junction assembly [GO:0007043]; heart contraction [GO:0060047]; heart development [GO:0007507]; vasculogenesis [GO:0001570] GO:0001570; GO:0005737; GO:0007043; GO:0007507; GO:0009948; GO:0060047 0 0 cd13516; PF16545; Q7TQK0 CHOYP_AAEL_AAEL004839.1.1 m.13815 sp CCNT2_MOUSE 64.815 270 91 3 2 268 7 275 3.15E-119 376 CCNT2_MOUSE reviewed Cyclin-T2 (CycT2) Ccnt2 Mus musculus (Mouse) 723 "cell cycle [GO:0007049]; cell division [GO:0051301]; early viral transcription [GO:0019085]; late viral transcription [GO:0019086]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of phosphorylation of RNA polymerase II C-terminal domain [GO:1901409]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of muscle cell differentiation [GO:0051147]; skeletal muscle tissue development [GO:0007519]; transcription, DNA-templated [GO:0006351]" GO:0000307; GO:0001223; GO:0003682; GO:0005634; GO:0006351; GO:0007049; GO:0007519; GO:0008024; GO:0016538; GO:0019085; GO:0019086; GO:0045737; GO:0045944; GO:0048471; GO:0051147; GO:0051301; GO:0070063; GO:0097322; GO:1901409 0 0 0 PF00134; Q8JIR0 CHOYP_BMI1A.1.2 m.38165 sp BMI1A_DANRE 54.093 281 106 8 21 298 1 261 3.15E-96 295 BMI1A_DANRE reviewed Polycomb complex protein BMI-1-A (Polycomb group RING finger protein 4-A) bmi1a bmi1 pcgf4a psc1 Danio rerio (Zebrafish) (Brachydanio rerio) 320 "cerebellum development [GO:0021549]; covalent chromatin modification [GO:0016569]; hematopoietic stem cell migration [GO:0035701]; negative regulation of gene expression, epigenetic [GO:0045814]; primitive hemopoiesis [GO:0060215]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0008270; GO:0016569; GO:0021549; GO:0031519; GO:0035701; GO:0045814; GO:0060215; GO:1990841 0 0 0 PF16207; Q8SWR3 CHOYP_NGR-A18.1.1 m.49034 sp SPR_DROME 24.202 376 233 13 41 386 80 433 3.15E-12 71.2 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q96DR7 CHOYP_ISCW_ISCW001487.2.2 m.61505 sp ARHGQ_HUMAN 42.489 466 247 6 1150 1608 414 865 3.15E-118 397 ARHGQ_HUMAN reviewed Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) ARHGEF26 SGEF HMFN1864 Homo sapiens (Human) 871 endothelial cell morphogenesis [GO:0001886]; regulation of Rho protein signal transduction [GO:0035023]; ruffle assembly [GO:0097178] GO:0001726; GO:0001886; GO:0005089; GO:0035023; GO:0097178 0 0 0 PF00621;PF14604; Q9QXT0 CHOYP_BRAFLDRAFT_123969.1.1 m.15145 sp CNPY2_MOUSE 42.484 153 84 3 3 152 20 171 3.15E-33 120 CNPY2_MOUSE reviewed Protein canopy homolog 2 (MIR-interacting saposin-like protein) (Putative secreted protein ZSIG9) (Transmembrane protein 4) Cnpy2 Msap Tmem4 Zsig9 Mus musculus (Mouse) 182 enzyme linked receptor protein signaling pathway [GO:0007167]; negative regulation of gene expression [GO:0010629]; positive regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045716]; regulation of low-density lipoprotein particle clearance [GO:0010988]; tissue development [GO:0009888] GO:0005783; GO:0007167; GO:0009888; GO:0010629; GO:0010988; GO:0045716 0 0 0 PF11938; Q9QXW2 CHOYP_NEMVEDRAFT_V1G239471.1.1 m.32242 sp FBXW5_MOUSE 28.226 248 164 8 4 247 9 246 3.15E-14 78.6 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9VCA2 CHOYP_CPIPJ_CPIJ001657.2.2 m.51992 sp ORCT_DROME 33.955 536 285 10 30 514 1 518 3.15E-79 261 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; D2GXS7 CHOYP_BRAFLDRAFT_88224.4.11 m.24228 sp TRIM2_AILME 23.333 300 196 9 300 575 455 744 3.16E-10 66.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_HMCN1.4.44 m.6307 sp HMCN1_MOUSE 30.088 113 72 4 22 134 2064 2169 3.16E-07 51.6 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O16025 CHOYP_LOC584481.5.10 m.52126 sp AOSL_PLEHO 32.532 707 426 18 68 733 370 1066 3.16E-105 348 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O46160 CHOYP_RL14.9.9 m.58703 sp RL14_LUMRU 65 140 48 1 76 214 5 144 3.16E-57 184 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O61462 CHOYP_RL37A.7.7 m.61010 sp RL37A_CRYST 84.783 92 14 0 1 92 1 92 3.16E-52 161 RL37A_CRYST reviewed 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) 92 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046872 0 0 0 PF01780; O96064 CHOYP_LOC100166368.1.1 m.44710 sp MYSP_MYTGA 77.163 289 66 0 99 387 576 864 3.16E-136 412 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P04962 CHOYP_CCNA.1.1 m.19223 sp CCNA_SPISO 55.752 113 49 1 4 116 310 421 3.16E-39 138 CCNA_SPISO reviewed G2/mitotic-specific cyclin-A 0 Spisula solidissima (Atlantic surf-clam) 422 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134;PF16500; P17978 CHOYP_BRAFLDRAFT_87268.3.4 m.60888 sp VGB_STAAU 30.645 124 80 5 286 404 88 210 3.16E-07 55.5 VGB_STAAU reviewed Virginiamycin B lyase (EC 4.2.99.-) (Streptogramin B lyase) vgb vgh Staphylococcus aureus 299 antibiotic catabolic process [GO:0017001]; response to antibiotic [GO:0046677] GO:0000287; GO:0016835; GO:0017001; GO:0046677 0 0 0 0 P18172 CHOYP_CPIPJ_CPIJ007618.1.1 m.53072 sp DHGL_DROPS 39.33 567 307 12 21 576 65 605 3.16E-117 364 DHGL_DROPS reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) 625 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; P18700 CHOYP_LOC373275.7.7 m.63851 sp TBB_STRPU 98.969 97 1 0 1 97 78 174 3.16E-67 206 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P43114 CHOYP_PE2R4.2.5 m.25531 sp PE2R4_RAT 28.084 381 217 9 14 344 7 380 3.16E-35 137 PE2R4_RAT reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Rattus norvegicus (Rat) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion [GO:1904460]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to interleukin-1 [GO:0070555]; response to organic cyclic compound [GO:0014070]; response to progesterone [GO:0032570]; response to prostaglandin E [GO:0034695]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0001934; GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0010628; GO:0010727; GO:0010840; GO:0014070; GO:0014911; GO:0030819; GO:0031965; GO:0032570; GO:0032720; GO:0032757; GO:0033624; GO:0034695; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045778; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050714; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0070555; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904460; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000386; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P45842 CHOYP_NEMVEDRAFT_V1G237122.1.6 m.13514 sp RL34_AEDAL 70.536 112 32 1 13 124 1 111 3.16E-48 153 RL34_AEDAL reviewed 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01199; P49446 CHOYP_PTPRC.11.14 m.47623 sp PTPRE_MOUSE 30.085 585 373 17 460 1013 70 649 3.16E-64 234 PTPRE_MOUSE reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) Ptpre Ptpe Mus musculus (Mouse) 699 negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0004725; GO:0005634; GO:0005737; GO:0005886; GO:0007185; GO:0016021; GO:0033003; GO:0042803; GO:0046627 0 0 0 PF00102; Q15723 CHOYP_LOC582205.1.1 m.54784 sp ELF2_HUMAN 44.776 67 34 1 124 190 197 260 3.16E-11 65.5 ELF2_HUMAN reviewed ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) ELF2 NERF Homo sapiens (Human) 593 "cell differentiation [GO:0030154]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006357; GO:0030154; GO:0043565; GO:0045892; GO:0045893 0 0 0 PF12310;PF00178; Q58588 CHOYP_BRAFLDRAFT_127093.1.3 m.10017 sp Y1187_METJA 23.256 344 197 9 37 366 6 296 3.16E-17 84.7 Y1187_METJA reviewed Uncharacterized protein MJ1187 (EC 3.2.2.-) MJ1187 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 301 0 GO:0016787 0 0 0 PF03747; Q5IS99 CHOYP_CASP3.1.3 m.23354 sp CASP3_SAIBB 29.545 88 58 1 28 115 188 271 3.16E-07 50.4 CASP3_SAIBB reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q5REH2 CHOYP_LOC100373598.1.1 m.60576 sp ZDHC6_PONAB 47.487 398 184 6 33 415 18 405 3.16E-130 384 ZDHC6_PONAB reviewed Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) ZDHHC6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 413 protein palmitoylation [GO:0018345] GO:0005789; GO:0008270; GO:0016021; GO:0018345; GO:0019706 0 0 0 PF07653;PF01529; Q5TM62 CHOYP_LOC100905387.1.1 m.30579 sp RT18B_MACMU 36.607 112 69 2 73 183 53 163 3.16E-19 87 RT18B_MACMU reviewed "28S ribosomal protein S18b, mitochondrial (MRP-S18-b) (Mrps18-b) (S18mt-b) (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2)" MRPS18B Macaca mulatta (Rhesus macaque) 258 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005840; GO:0006412 0 0 0 PF01084; Q5ZL74 CHOYP_BRAFLDRAFT_215087.1.1 m.66618 sp VAMP7_CHICK 68.837 215 67 0 1 215 1 215 3.16E-102 297 VAMP7_CHICK reviewed Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 SYBL1 RCJMB04_7f19 Gallus gallus (Chicken) 220 "calcium ion regulated exocytosis [GO:0017156]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of histamine secretion by mast cell [GO:1903595]; regulation of protein targeting to vacuolar membrane [GO:1900483]; SNARE complex assembly [GO:0035493]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" GO:0000149; GO:0005484; GO:0005765; GO:0005789; GO:0005802; GO:0005886; GO:0006887; GO:0006888; GO:0006897; GO:0006906; GO:0006911; GO:0008333; GO:0009986; GO:0016021; GO:0016192; GO:0017156; GO:0030027; GO:0030054; GO:0030658; GO:0030670; GO:0031091; GO:0031143; GO:0031201; GO:0031902; GO:0035493; GO:0035577; GO:0043001; GO:0043005; GO:0043308; GO:0043312; GO:0043320; GO:0045177; GO:0045202; GO:0045335; GO:0048471; GO:0050775; GO:0070062; GO:1900483; GO:1903595 0 0 0 PF13774;PF00957; Q6PFY8 CHOYP_TRI45.3.23 m.3967 sp TRI45_MOUSE 28.906 256 163 8 8 256 129 372 3.16E-13 74.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7ZYJ3 CHOYP_AGK.1.1 m.30589 sp AGK_XENLA 36.552 435 250 10 1 430 1 414 3.16E-84 267 AGK_XENLA reviewed "Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.94) (Multiple substrate lipid kinase) (MuLK) (Multi-substrate lipid kinase)" agk mulk Xenopus laevis (African clawed frog) 428 glycerolipid metabolic process [GO:0046486] GO:0004143; GO:0005524; GO:0031966; GO:0046486; GO:0047620 PATHWAY: Lipid metabolism; glycerolipid metabolism. 0 0 PF00781; Q8N6D5 CHOYP_TVAG_123950.6.31 m.32645 sp ANR29_HUMAN 41.86 129 75 0 4 132 62 190 3.16E-27 105 ANR29_HUMAN reviewed Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) 301 0 0 0 0 0 PF00023;PF12796; Q8NF91 CHOYP_SYNE1.1.1 m.51183 sp SYNE1_HUMAN 37.024 551 332 6 1414 1957 7675 8217 3.16E-98 360 SYNE1_HUMAN reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) SYNE1 C6orf98 KIAA0796 KIAA1262 KIAA1756 MYNE1 Homo sapiens (Human) 8797 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; nucleus organization [GO:0006997] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0006997; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q8R5M3 CHOYP_LRC15.2.3 m.43746 sp LRC15_RAT 25.828 604 356 10 3 592 8 533 3.16E-44 171 LRC15_RAT reviewed Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid) (rLib) Lrrc15 Lib Rattus norvegicus (Rat) 578 cell communication [GO:0007154]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469] GO:0004860; GO:0005622; GO:0005737; GO:0006469; GO:0007154; GO:0016021; GO:0019221; GO:0046426 0 0 0 PF00560;PF13855; Q921Y2 CHOYP_LOC100371776.3.3 m.61724 sp IMP3_MOUSE 64.286 182 64 1 1 181 1 182 3.16E-88 259 IMP3_MOUSE reviewed U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) Imp3 Mus musculus (Mouse) 184 rRNA processing [GO:0006364] GO:0005634; GO:0005730; GO:0006364; GO:0030515; GO:0030519; GO:0032040; GO:0034457; GO:0044822 0 0 0 PF00163;PF01479; Q96MM6 CHOYP_BRAFLDRAFT_208436.9.32 m.36683 sp HS12B_HUMAN 34.333 667 357 16 7 604 32 686 3.16E-116 364 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9ESN6 CHOYP_TRIM2.12.59 m.23975 sp TRIM2_MOUSE 25.346 217 145 7 9 217 535 742 3.16E-09 59.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAR2 CHOYP_CELR2.7.8 m.54287 sp AGRL3_HUMAN 26.212 763 470 28 326 1046 495 1206 3.16E-57 220 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9PW38 CHOYP_GEPH.2.2 m.56703 sp GEPH_CHICK 61.765 170 65 0 24 193 15 184 3.16E-60 221 GEPH_CHICK reviewed Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] GPHN Gallus gallus (Chicken) 736 gamma-aminobutyric acid receptor clustering [GO:0097112]; glycine receptor clustering [GO:0072579]; molybdenum incorporation into molybdenum-molybdopterin complex [GO:0018315]; molybdopterin cofactor biosynthetic process [GO:0032324]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0005524; GO:0005737; GO:0005856; GO:0006777; GO:0018315; GO:0030054; GO:0030425; GO:0032324; GO:0045211; GO:0046872; GO:0061598; GO:0061599; GO:0072579; GO:0097112 PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000250|UniProtKB:Q9NQX3}. 0 0 PF00994;PF03454;PF03453; Q9R0M6 CHOYP_RAB9A.1.1 m.59036 sp RAB9A_MOUSE 67.327 202 65 1 1 202 1 201 3.16E-98 286 RAB9A_MOUSE reviewed Ras-related protein Rab-9A (Sid 99) Rab9a Rab9 Sid99 Mus musculus (Mouse) 201 "negative regulation by host of symbiont molecular function [GO:0052405]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]; small GTPase mediated signal transduction [GO:0007264]" GO:0000139; GO:0003924; GO:0005525; GO:0005764; GO:0005770; GO:0005789; GO:0005829; GO:0005886; GO:0007264; GO:0015031; GO:0019003; GO:0030659; GO:0030670; GO:0032880; GO:0042147; GO:0045335; GO:0045921; GO:0052405; GO:0070062 0 0 0 PF00071; Q9R0W9 CHOYP_BRAFLDRAFT_174537.2.2 m.56332 sp ACHA6_MOUSE 26.649 379 248 14 3 363 15 381 3.16E-28 119 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9VTP4 CHOYP_LOC100898717.3.3 m.37209 sp R10AB_DROME 68.056 144 46 0 11 154 43 186 3.16E-59 186 R10AB_DROME reviewed 60S ribosomal protein L10a-2 RpL10Ab CG7283 Drosophila melanogaster (Fruit fly) 217 centrosome duplication [GO:0051298]; maturation of LSU-rRNA [GO:0000470]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; translation [GO:0006412] GO:0000022; GO:0000470; GO:0003723; GO:0003735; GO:0006412; GO:0007052; GO:0022625; GO:0051298 0 0 cd00403; PF00687; Q9VZW5 CHOYP_NTR1.1.1 m.66237 sp FMAR_DROME 30.255 314 208 3 27 335 103 410 3.16E-38 147 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; A8WT26 CHOYP_DHSD.1.1 m.63494 sp DHSD_CAEBR 42.342 111 54 2 88 192 39 145 3.17E-22 90.5 DHSD_CAEBR reviewed "Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (Succinate dehydrogenase complex subunit D)" sdhd-1 CBG02978 Caenorhabditis briggsae 145 tricarboxylic acid cycle [GO:0006099] GO:0005740; GO:0005743; GO:0005749; GO:0006099; GO:0016021; GO:0020037; GO:0046872; GO:0048039 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle. {ECO:0000305}. 0 cd03496; 0 E9Q555 CHOYP_BRAFLDRAFT_68766.3.4 m.18672 sp RN213_MOUSE 28.837 430 241 15 185 598 1232 1612 3.17E-43 171 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O43301 CHOYP_LOC100223480.2.4 m.6757 sp HS12A_HUMAN 29.231 520 296 13 12 465 149 662 3.17E-65 225 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O57593 CHOYP_SURF1.2.2 m.40141 sp SURF1_TAKRU 29.583 240 153 5 75 307 3 233 3.17E-30 118 SURF1_TAKRU reviewed Surfeit locus protein 1 (Fragment) surf1 surf-1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 240 embryonic organ development [GO:0048568]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; spinal cord motor neuron differentiation [GO:0021522] GO:0004129; GO:0005743; GO:0016021; GO:0021522; GO:0033617; GO:0048568 0 0 cd06662; PF02104; O75691 CHOYP_UTP20.4.4 m.27797 sp UTP20_HUMAN 39.49 157 93 1 1 155 714 870 3.17E-30 119 UTP20_HUMAN reviewed Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) 2785 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of cell proliferation [GO:0008285]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0008285; GO:0030686; GO:0030688; GO:0032040; GO:0044822 0 0 0 PF07539; O97596 CHOYP_BRAFLDRAFT_120634.1.1 m.17533 sp S20A1_FELCA 42.009 657 285 6 7 567 24 680 3.17E-171 504 S20A1_FELCA reviewed Sodium-dependent phosphate transporter 1 (Feline leukemia virus subtype-B receptor) (Phosphate transporter 1) (PiT-1) (Solute carrier family 20 member 1) Slc20a1 Pit1 Felis catus (Cat) (Felis silvestris catus) 681 positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005315; GO:0005887; GO:0015319; GO:0043123 0 0 0 PF01384; P00690 CHOYP_AMY.1.3 m.12085 sp AMYP_PIG 47.764 492 247 7 28 513 24 511 3.17E-158 463 AMYP_PIG reviewed "Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)" AMY2 Sus scrofa (Pig) 511 carbohydrate catabolic process [GO:0016052] GO:0004556; GO:0005509; GO:0005615; GO:0016052; GO:0031404 0 0 0 PF00128;PF02806; P04058 CHOYP_LOC591290.3.3 m.65143 sp ACES_TETCF 44.809 549 275 7 31 572 29 556 3.17E-164 486 ACES_TETCF reviewed Acetylcholinesterase (AChE) (EC 3.1.1.7) ache Tetronarce californica (Pacific electric ray) (Torpedo californica) 586 acetylcholine catabolic process in synaptic cleft [GO:0001507] GO:0001507; GO:0003990; GO:0005886; GO:0030054; GO:0031225; GO:0043083 0 0 0 PF00135; P07909 CHOYP_AGAP_AGAP002374.1.1 m.49199 sp ROA1_DROME 58.721 172 70 1 13 183 26 197 3.17E-64 208 ROA1_DROME reviewed Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (PEN repeat clone P9) (hnRNP core protein A1-A) Hrb98DE Pen9 CG9983 Drosophila melanogaster (Fruit fly) 365 "compound eye morphogenesis [GO:0001745]; female germ-line stem cell population maintenance [GO:0036099]; negative regulation of RNA splicing [GO:0033119]; oogenesis [GO:0048477]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of glucose metabolic process [GO:0010906]; sensory perception of pain [GO:0019233]" GO:0000166; GO:0000381; GO:0001745; GO:0003729; GO:0005634; GO:0005703; GO:0010906; GO:0019233; GO:0030529; GO:0033119; GO:0036099; GO:0043565; GO:0045727; GO:0048027; GO:0048477 0 0 0 PF00076; P40792 CHOYP_GSTUM_00003067001.1.1 m.56677 sp RAC1_DROME 36.126 191 104 5 7 179 2 192 3.17E-33 120 RAC1_DROME reviewed Ras-related protein Rac1 Rac1 RacA CG2248 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; activation of protein kinase activity [GO:0032147]; adherens junction maintenance [GO:0034334]; axonal fasciculation [GO:0007413]; axon extension [GO:0048675]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; border follicle cell migration [GO:0007298]; cell-cell junction organization [GO:0045216]; cell competition in a multicellular organism [GO:0035212]; cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; cortical actin cytoskeleton organization [GO:0030866]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; determination of digestive tract left/right asymmetry [GO:0071907]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; dorsal closure, amnioserosa morphology change [GO:0046664]; dorsal closure, elongation of leading edge cells [GO:0007394]; dorsal closure, spreading of leading edge cells [GO:0007395]; embryonic anterior midgut (ectodermal) morphogenesis [GO:0048615]; encapsulation of foreign target [GO:0035010]; establishment of ommatidial planar polarity [GO:0042067]; establishment of tissue polarity [GO:0007164]; germ-band shortening [GO:0007390]; glial cell migration [GO:0008347]; head involution [GO:0008258]; hemocyte development [GO:0007516]; hemocyte migration [GO:0035099]; imaginal disc-derived wing hair site selection [GO:0035320]; immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [GO:0002433]; JNK cascade [GO:0007254]; lamellipodium assembly [GO:0030032]; melanotic encapsulation of foreign target [GO:0035011]; mesodermal cell migration [GO:0008078]; microtubule-based process [GO:0007017]; morphogenesis of larval imaginal disc epithelium [GO:0016335]; motor neuron axon guidance [GO:0008045]; muscle attachment [GO:0016203]; muscle fiber development [GO:0048747]; myoblast fusion [GO:0007520]; myoblast proliferation [GO:0051450]; negative regulation of lamellipodium assembly [GO:0010593]; nephrocyte filtration [GO:0097206]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; peripheral nervous system development [GO:0007422]; phagocytosis [GO:0006909]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; regulation of axonogenesis [GO:0050770]; regulation of cell cycle [GO:0051726]; regulation of dendrite morphogenesis [GO:0048814]; regulation of hemocyte differentiation [GO:0045610]; regulation of locomotor rhythm [GO:1904059]; regulation of synapse assembly [GO:0051963]; regulation of synapse organization [GO:0050807]; rhabdomere development [GO:0042052]; salivary gland morphogenesis [GO:0007435]; sensory perception of touch [GO:0050975]; small GTPase mediated signal transduction [GO:0007264]; tracheal outgrowth, open tracheal system [GO:0007426]; ventral cord development [GO:0007419]" GO:0000902; GO:0001726; GO:0001954; GO:0002433; GO:0003924; GO:0005525; GO:0005737; GO:0005829; GO:0005886; GO:0006909; GO:0006974; GO:0007015; GO:0007017; GO:0007164; GO:0007254; GO:0007264; GO:0007298; GO:0007390; GO:0007391; GO:0007394; GO:0007395; GO:0007411; GO:0007413; GO:0007419; GO:0007422; GO:0007424; GO:0007426; GO:0007435; GO:0007516; GO:0007520; GO:0008045; GO:0008078; GO:0008258; GO:0008283; GO:0008347; GO:0010593; GO:0016028; GO:0016199; GO:0016203; GO:0016335; GO:0016358; GO:0019897; GO:0019901; GO:0030032; GO:0030036; GO:0030707; GO:0030866; GO:0031175; GO:0031532; GO:0032147; GO:0032794; GO:0034334; GO:0035010; GO:0035011; GO:0035099; GO:0035212; GO:0035320; GO:0042052; GO:0042067; GO:0045216; GO:0045610; GO:0045773; GO:0046664; GO:0046843; GO:0048615; GO:0048675; GO:0048747; GO:0048812; GO:0048813; GO:0048814; GO:0050770; GO:0050807; GO:0050975; GO:0051017; GO:0051450; GO:0051491; GO:0051726; GO:0051963; GO:0071902; GO:0071907; GO:0090303; GO:0097206; GO:1902669; GO:1904059 0 0 0 PF00071; Q09288 CHOYP_YQK4.2.2 m.31850 sp YQK4_CAEEL 23.649 444 264 17 32 438 21 426 3.17E-17 90.1 YQK4_CAEEL reviewed Uncharacterized protein C56G2.4 C56G2.4 Caenorhabditis elegans 538 0 0 0 0 0 PF01161; Q24617 CHOYP_LOC100570029.2.3 m.27324 sp EXU2_DROPS 24.183 153 103 3 437 577 32 183 3.17E-08 60.5 EXU2_DROPS reviewed Maternal protein exuperantia-2 exu2 Drosophila pseudoobscura pseudoobscura (Fruit fly) 477 multicellular organism development [GO:0007275] GO:0003723; GO:0007275 0 0 0 0 Q26481 CHOYP_RL5.3.4 m.42058 sp RL5_STYCL 78.261 207 45 0 1 207 51 257 3.17E-119 343 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q26636 CHOYP_LOC659226.2.3 m.60474 sp CATL_SARPE 55.238 315 134 2 53 360 25 339 3.17E-127 371 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q2EMV9 CHOYP_BRAFLDRAFT_91321.7.10 m.56158 sp PAR14_MOUSE 24.577 1123 766 30 463 1547 140 1219 3.17E-74 279 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5RC32 CHOYP_LOC100372481.1.1 m.21011 sp MDM1_PONAB 30.081 246 122 11 236 477 162 361 3.17E-12 72.8 MDM1_PONAB reviewed Nuclear protein MDM1 MDM1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 724 negative regulation of centriole replication [GO:0046600] GO:0005634; GO:0005813; GO:0005814; GO:0005874; GO:0008017; GO:0046600 0 0 0 PF15501; Q62417 CHOYP_LOC100867381.8.8 m.53059 sp SRBS1_MOUSE 41.434 251 116 7 1434 1674 980 1209 3.17E-44 180 SRBS1_MOUSE reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Sorbs1 Kiaa1296 Sh3d5 Mus musculus (Mouse) 1290 cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005856; GO:0005886; GO:0005913; GO:0005924; GO:0005925; GO:0008134; GO:0008286; GO:0015758; GO:0016020; GO:0016363; GO:0019901; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q642M9 CHOYP_DPSE_GA17556.1.1 m.111 sp DHDH_DANRE 46.259 147 79 0 18 164 1 147 3.17E-42 146 DHDH_DANRE reviewed "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh ch211-203b17.3 zgc:101723 Danio rerio (Zebrafish) (Brachydanio rerio) 334 D-xylose catabolic process [GO:0042843] GO:0042843; GO:0047115; GO:0047837 0 0 0 PF01408; Q6AXV7 CHOYP_LOC101160558.1.1 m.47852 sp F187A_RAT 26.616 263 158 11 240 482 148 395 3.17E-10 65.9 F187A_RAT reviewed Ig-like V-type domain-containing protein FAM187A Fam187a Rattus norvegicus (Rat) 418 0 GO:0016021 0 0 0 PF07686; Q6DFV8 CHOYP_NEMVEDRAFT_V1G214844.2.34 m.2881 sp VWDE_MOUSE 22.874 341 234 12 59 391 264 583 3.17E-08 59.7 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6MG82 CHOYP_LOC100557152.2.3 m.50935 sp PRRT1_RAT 42.466 73 42 0 82 154 221 293 3.17E-13 68.9 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6R795 CHOYP_Y116.1.1 m.29512 sp Y116_OSHVF 98.765 243 3 0 1 243 1 243 3.17E-179 495 Y116_OSHVF reviewed Uncharacterized protein ORF116 ORF116 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 256 0 0 0 0 0 0 Q6R7G0 CHOYP_POL4.1.4 m.8083 sp Y068_OSHVF 22.205 635 428 13 3 572 5 638 3.17E-43 170 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6ZRF8 CHOYP_LOC100369929.5.5 m.65260 sp RN207_HUMAN 20.321 187 136 5 1 185 119 294 3.17E-07 56.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7Z5P9 CHOYP_Y2550.1.2 m.750 sp MUC19_HUMAN 35.236 911 440 48 251 1079 3889 4731 3.17E-16 89 MUC19_HUMAN reviewed Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) 8384 O-glycan processing [GO:0016266] GO:0005796; GO:0016266; GO:0070062 0 0 0 PF08742;PF01826;PF00094; Q8N2R8 CHOYP_BRAFLDRAFT_209933.1.1 m.29283 sp FA43A_HUMAN 28.205 156 106 3 1 151 53 207 3.17E-18 86.7 FA43A_HUMAN reviewed Protein FAM43A FAM43A PP7298 Homo sapiens (Human) 423 0 0 0 0 0 PF14719; Q8ND30 CHOYP_LIPB1.1.1 m.35961 sp LIPB2_HUMAN 39.515 701 324 17 207 823 154 838 3.17E-144 451 LIPB2_HUMAN reviewed Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) PPFIBP2 Homo sapiens (Human) 876 0 GO:0005615; GO:0005622 0 0 0 PF00536;PF07647; Q96MM6 CHOYP_BRAFLDRAFT_208436.18.32 m.58763 sp HS12B_HUMAN 28.12 569 334 20 110 611 61 621 3.17E-59 213 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9N2J2 CHOYP_GPX4-A.1.1 m.257 sp GPX4_BOVIN 48.936 47 24 0 76 122 26 72 3.17E-10 58.2 GPX4_BOVIN reviewed "Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4)" GPX4 Bos taurus (Bovine) 197 multicellular organism development [GO:0007275]; response to oxidative stress [GO:0006979] GO:0004602; GO:0005739; GO:0006979; GO:0007275; GO:0047066 0 0 cd00340; PF00255; Q9Y673 CHOYP_ALG5.1.1 m.19649 sp ALG5_HUMAN 62.583 302 112 1 20 321 23 323 3.17E-147 420 ALG5_HUMAN reviewed Dolichyl-phosphate beta-glucosyltransferase (DolP-glucosyltransferase) (EC 2.4.1.117) (Asparagine-linked glycosylation protein 5 homolog) ALG5 HSPC149 Homo sapiens (Human) 324 determination of left/right symmetry [GO:0007368]; dolichol metabolic process [GO:0019348]; GPI anchor biosynthetic process [GO:0006506]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; protein O-linked mannosylation [GO:0035269] GO:0004169; GO:0004576; GO:0004581; GO:0004582; GO:0005789; GO:0006486; GO:0006487; GO:0006506; GO:0007368; GO:0016020; GO:0016021; GO:0018279; GO:0019348; GO:0035269 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535; A6BM72 CHOYP_MEG10.11.91 m.21604 sp MEG11_HUMAN 37.398 246 135 11 174 419 427 653 3.18E-27 120 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; F1ND48 CHOYP_BRAFLDRAFT_252309.1.2 m.2996 sp FBH1_CHICK 42.063 126 72 1 1 126 355 479 3.18E-25 103 FBH1_CHICK reviewed F-box DNA helicase 1 (EC 3.6.4.12) (F-box only protein 18) FBXO18 FBH1 FBX18 Gallus gallus (Chicken) 1012 "cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of chromatin binding [GO:0035562]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; replication fork protection [GO:0048478]; response to intra-S DNA damage checkpoint signaling [GO:0072429]" GO:0000724; GO:0000737; GO:0000785; GO:0001934; GO:0003678; GO:0003690; GO:0003697; GO:0004003; GO:0005524; GO:0005634; GO:0006974; GO:0008219; GO:0015616; GO:0016567; GO:0019005; GO:0031297; GO:0035562; GO:0043138; GO:0048478; GO:0072429; GO:1902231; GO:2000042 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8NFZ0}. 0 0 PF12937;PF13361; O60462 CHOYP_NRP1.5.5 m.51613 sp NRP2_HUMAN 29.536 237 138 11 56 279 45 265 3.18E-18 90.1 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P16157 CHOYP_AFUA_1G01020.8.50 m.21049 sp ANK1_HUMAN 38.519 270 166 0 5 274 223 492 3.18E-50 180 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P23953 CHOYP_LOC100367670.2.2 m.34300 sp EST1C_MOUSE 32.299 548 291 19 46 563 50 547 3.18E-68 233 EST1C_MOUSE reviewed Carboxylesterase 1C (EC 3.1.1.1) (Liver carboxylesterase N) (Lung surfactant convertase) (PES-N) Ces1c Es1 Mus musculus (Mouse) 554 0 GO:0005615; GO:0005788; GO:0016788; GO:0052689 0 0 0 PF00135; P41950 CHOYP_MEG11.18.25 m.52105 sp DEX1_CAEEL 43.478 46 23 1 2 47 318 360 3.18E-06 48.9 DEX1_CAEEL reviewed Dendrite extension defective protein 1 dex-1 D1044.2 Caenorhabditis elegans 1090 amphid sensory organ dendrite retrograde extension [GO:0003391]; cell-matrix adhesion [GO:0007160] GO:0003391; GO:0005509; GO:0005576; GO:0007160; GO:0016021; GO:0030425; GO:0032590 0 0 0 PF12947;PF06119; P52168 CHOYP_GATA1.2.2 m.27279 sp PNR_DROME 52.571 175 30 3 310 484 160 281 3.18E-48 181 PNR_DROME reviewed GATA-binding factor A (Protein pannier) (Transcription factor GATA-A) (dGATA-A) pnr GATA-A CG3978 Drosophila melanogaster (Fruit fly) 540 "anatomical structure formation involved in morphogenesis [GO:0048646]; blastoderm segmentation [GO:0007350]; cardioblast cell fate determination [GO:0007510]; cardioblast differentiation [GO:0010002]; cardiocyte differentiation [GO:0035051]; cell development [GO:0048468]; cell differentiation [GO:0030154]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; digestive tract development [GO:0048565]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic heart tube development [GO:0035050]; heart contraction [GO:0060047]; heart development [GO:0007507]; lymph gland development [GO:0048542]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pattern specification process [GO:0007389]; pericardial nephrocyte differentiation [GO:0061320]; pigment metabolic process [GO:0042440]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of antimicrobial peptide biosynthetic process [GO:0002805]; regulation of glucose metabolic process [GO:0010906]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000122; GO:0000977; GO:0000981; GO:0000983; GO:0001085; GO:0001103; GO:0001228; GO:0002805; GO:0003682; GO:0003700; GO:0005634; GO:0005667; GO:0007179; GO:0007350; GO:0007389; GO:0007391; GO:0007398; GO:0007507; GO:0007510; GO:0008270; GO:0008407; GO:0010002; GO:0010906; GO:0022416; GO:0030154; GO:0035050; GO:0035051; GO:0042440; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0048468; GO:0048542; GO:0048565; GO:0048646; GO:0060047; GO:0061320 0 0 0 PF00320; Q09654 CHOYP_BRAFLDRAFT_88217.6.14 m.32424 sp TRI23_CAEEL 25.962 208 121 8 25 210 118 314 3.18E-07 55.5 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q12955 CHOYP_LOC100639010.8.9 m.56682 sp ANK3_HUMAN 31.558 507 313 3 2 475 267 772 3.18E-74 258 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q14980 CHOYP_CENPE.1.1 m.19368 sp NUMA1_HUMAN 24.402 627 290 26 1656 2143 1476 2057 3.18E-13 79.7 NUMA1_HUMAN reviewed Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) 2115 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997] GO:0000132; GO:0000139; GO:0000922; GO:0005198; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005876; GO:0005938; GO:0006997; GO:0007067; GO:0016363; GO:0030425; GO:0043025; GO:0045177; GO:0051301; GO:0051321; GO:0060487; GO:0061673; GO:0070062; GO:0072686; GO:0097431 0 0 0 0 Q24118 CHOYP_LOC100371940.1.1 m.2789 sp PIGE_DROME 23.483 1005 580 30 39 981 28 905 3.18E-63 234 PIGE_DROME reviewed Protein pigeon (Protein linotte) pigeon lio CG10739 Drosophila melanogaster (Fruit fly) 915 0 0 0 0 0 PF14959; Q5R7B4 CHOYP_LOC100499484-C9ORF174.1.1 m.14315 sp STRA6_PONAB 25.403 248 161 5 401 635 421 657 3.18E-14 79.7 STRA6_PONAB reviewed Stimulated by retinoic acid gene 6 protein homolog STRA6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 667 0 GO:0004872; GO:0005886; GO:0016021; GO:0051183 0 0 0 0 Q5ZJH7 CHOYP_WNT14.1.1 m.22470 sp CNPD1_CHICK 45.763 177 90 2 24 194 6 182 3.18E-48 174 CNPD1_CHICK reviewed Protein CNPPD1 CNPPD1 RCJMB04_3a20 Gallus gallus (Chicken) 439 regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079] GO:0000079; GO:0016021 0 0 0 PF08613; Q66J99 CHOYP_BRAFLDRAFT_118255.1.1 m.14436 sp RBM18_XENLA 43.671 158 78 4 10 160 18 171 3.18E-38 132 RBM18_XENLA reviewed Probable RNA-binding protein 18 (RNA-binding motif protein 18) rbm18 Xenopus laevis (African clawed frog) 190 0 GO:0000166; GO:0003723 0 0 0 PF00076; Q6GMG8 CHOYP_NEMVEDRAFT_V1G129909.6.9 m.26482 sp LITAF_DANRE 41.129 124 63 4 25 147 49 163 3.18E-21 87 LITAF_DANRE reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf zgc:91882 Danio rerio (Zebrafish) (Brachydanio rerio) 163 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006355 0 0 0 PF10601; Q6R7F4 CHOYP_Y075.1.1 m.30940 sp Y075_OSHVF 99.149 235 2 0 1 235 1 235 3.18E-174 481 Y075_OSHVF reviewed Uncharacterized protein ORF75 ORF75 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 236 dUTP metabolic process [GO:0046080] GO:0016787; GO:0046080 0 0 0 PF00692; Q70CQ4 CHOYP_CPIPJ_CPIJ000241.1.1 m.56306 sp UBP31_HUMAN 37.283 692 345 16 120 737 126 802 3.18E-126 424 UBP31_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) USP31 KIAA1203 Homo sapiens (Human) 1352 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005634; GO:0006511; GO:0016579 0 0 0 PF00443; Q8IX30 CHOYP_PCSK5.2.2 m.23478 sp SCUB3_HUMAN 30.811 185 114 5 15 189 624 804 3.18E-15 80.5 SCUB3_HUMAN reviewed "Signal peptide, CUB and EGF-like domain-containing protein 3" SCUBE3 CEGF3 Homo sapiens (Human) 993 protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] GO:0005509; GO:0005576; GO:0009986; GO:0051260; GO:0051291 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q9CR58 CHOYP_LOC584986.1.1 m.19294 sp KMCP1_MOUSE 58.784 148 59 1 9 156 144 289 3.18E-58 186 KMCP1_MOUSE reviewed Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) Slc25a30 Kmcp1 Mus musculus (Mouse) 291 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q9CU65 CHOYP_LOC764748.1.3 m.7938 sp ZMYM2_MOUSE 24.583 240 161 6 56 278 1121 1357 3.18E-06 53.1 ZMYM2_MOUSE reviewed Zinc finger MYM-type protein 2 (Zinc finger protein 198) Zmym2 Zfp198 Znf198 Mus musculus (Mouse) 1376 "cytoskeleton organization [GO:0007010]; multicellular organism development [GO:0007275]; regulation of cell morphogenesis [GO:0022604]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0005654; GO:0005737; GO:0006351; GO:0007010; GO:0007275; GO:0008270; GO:0016605; GO:0022604; GO:0031624 0 0 0 PF12012;PF06467; Q9CZJ2 CHOYP_HS12A.14.33 m.41988 sp HS12B_MOUSE 27.83 636 381 15 37 606 61 684 3.18E-73 254 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9ESN6 CHOYP_TRIM3.50.58 m.53312 sp TRIM2_MOUSE 26.887 212 144 6 67 272 536 742 3.18E-13 72.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9U639 CHOYP_HSPA8.1.1 m.62795 sp HSP7D_MANSE 85.065 154 23 0 8 161 6 159 3.18E-92 285 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9Z1J2 CHOYP_NEK4.8.8 m.66902 sp NEK4_MOUSE 36.275 306 185 4 13 317 11 307 3.18E-58 203 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; A5D794 CHOYP_LOC100645706.1.1 m.62733 sp GAPD1_BOVIN 49.548 442 206 5 1284 1709 970 1410 3.19E-130 446 GAPD1_BOVIN reviewed GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Bos taurus (Bovine) 1413 endocytosis [GO:0006897]; regulation of protein transport [GO:0051223]; signal transduction [GO:0007165] GO:0005085; GO:0005096; GO:0005768; GO:0005829; GO:0006897; GO:0007165; GO:0016020; GO:0032794; GO:0051223 0 0 0 PF00616;PF02204; A7MB63 CHOYP_LOC100187335.1.2 m.10705 sp CTNS_BOVIN 49.706 340 160 4 45 383 38 367 3.19E-118 351 CTNS_BOVIN reviewed Cystinosin CTNS Bos taurus (Bovine) 367 adult walking behavior [GO:0007628]; ATP metabolic process [GO:0046034]; brain development [GO:0007420]; glutathione metabolic process [GO:0006749]; grooming behavior [GO:0007625]; L-cystine transport [GO:0015811]; lens development in camera-type eye [GO:0002088]; long-term memory [GO:0007616]; melanin biosynthetic process [GO:0042438]; visual learning [GO:0008542] GO:0002088; GO:0005765; GO:0005770; GO:0005886; GO:0006749; GO:0007420; GO:0007616; GO:0007625; GO:0007628; GO:0008542; GO:0015184; GO:0015811; GO:0016021; GO:0042438; GO:0042470; GO:0045111; GO:0046034; GO:0070062 0 0 0 PF04193; F1LQ48 CHOYP_ND4.3.5 m.19536 sp HNRPL_RAT 47.378 553 238 10 20 544 90 617 3.19E-161 476 HNRPL_RAT reviewed Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Hnrnpl Fblim1 Rattus norvegicus (Rat) 623 "cellular response to amino acid starvation [GO:0034198]; circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA binding [GO:1902416]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to peptide [GO:1901652]" GO:0000166; GO:0000381; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006397; GO:0007623; GO:0030529; GO:0034198; GO:0035770; GO:0044212; GO:0045727; GO:0048025; GO:0048471; GO:0097157; GO:1901652; GO:1902416; GO:1990715 0 0 0 PF00076; O75954 CHOYP_DGRI_GH15333.1.2 m.45725 sp TSN9_HUMAN 24.723 271 167 5 3 273 2 235 3.19E-17 82 TSN9_HUMAN reviewed Tetraspanin-9 (Tspan-9) (Tetraspan NET-5) TSPAN9 NET5 Homo sapiens (Human) 239 cell surface receptor signaling pathway [GO:0007166] GO:0005886; GO:0005887; GO:0005925; GO:0007166; GO:0097197 0 0 0 PF00335; P02552 CHOYP_TBA1A.3.4 m.25624 sp TBA1_CHICK 92.818 181 12 1 40 220 221 400 3.19E-123 359 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P18433 CHOYP_PTPRM.8.15 m.46480 sp PTPRA_HUMAN 30.441 680 421 21 7 663 138 788 3.19E-83 282 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P30151 CHOYP_EF1B.6.7 m.66696 sp EF1B_XENLA 65.196 204 64 2 89 285 1 204 3.19E-87 262 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P91753 CHOYP_DMOJ_GI15072.1.1 m.5417 sp MP62_LYTPI 38.587 184 92 5 72 239 2 180 3.19E-18 87.8 MP62_LYTPI reviewed Mitotic apparatus protein p62 0 Lytechinus pictus (Painted sea urchin) 411 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0003676; GO:0005634; GO:0007067; GO:0051301 0 0 0 PF16276;PF03066; P97864 CHOYP_CASP7.4.23 m.12470 sp CASP7_MOUSE 28.8 250 143 10 12 241 67 301 3.19E-20 90.5 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q12955 CHOYP_AASI_1435.6.35 m.32608 sp ANK3_HUMAN 33.069 505 322 3 738 1242 206 694 3.19E-66 251 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q14444 CHOYP_CAPR1.1.1 m.37149 sp CAPR1_HUMAN 45.05 202 111 0 20 221 54 255 3.19E-51 184 CAPR1_HUMAN reviewed Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 Homo sapiens (Human) 709 negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003] GO:0000932; GO:0003723; GO:0005737; GO:0005829; GO:0005887; GO:0010494; GO:0016020; GO:0017148; GO:0030425; GO:0044822; GO:0050775; GO:0061003 0 0 0 PF12287; Q27IV2 CHOYP_SHROOM3.1.1 m.15543 sp SHRM3_XENLA 35.806 310 174 6 2005 2305 1463 1756 3.19E-40 168 SHRM3_XENLA reviewed Protein Shroom3 (Shroom-like protein) shroom3 shrm Xenopus laevis (African clawed frog) 1788 apical protein localization [GO:0045176]; cell morphogenesis [GO:0000902]; cellular pigment accumulation [GO:0043482]; epithelial cell development [GO:0002064]; neural tube closure [GO:0001843]; pattern specification process [GO:0007389]; regulation of cell shape [GO:0008360] GO:0000902; GO:0001843; GO:0002064; GO:0003779; GO:0005737; GO:0005856; GO:0005874; GO:0005912; GO:0007389; GO:0008360; GO:0016324; GO:0043482; GO:0045176 0 0 0 PF08688;PF08687; Q4R5P1 CHOYP_RAB8A.3.3 m.47962 sp RAB8A_MACFA 84.135 208 31 2 45 251 1 207 3.19E-125 357 RAB8A_MACFA reviewed Ras-related protein Rab-8A RAB8A QccE-11745 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 207 axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0042384]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005794; GO:0005814; GO:0005886; GO:0005929; GO:0007264; GO:0007409; GO:0015031; GO:0017137; GO:0019003; GO:0030670; GO:0032869; GO:0042384; GO:0045335; GO:0055038; GO:0072659 0 0 0 PF00071; Q58DT0 CHOYP_LOC100878929.1.1 m.58154 sp ELF5_BOVIN 49.495 99 43 2 267 365 164 255 3.19E-22 97.4 ELF5_BOVIN reviewed ETS-related transcription factor Elf-5 (E74-like factor 5) ELF5 Bos taurus (Bovine) 255 cell differentiation [GO:0030154]; ectodermal cell fate commitment [GO:0001712]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell differentiation [GO:0045596]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; somatic stem cell population maintenance [GO:0035019] GO:0000977; GO:0000981; GO:0001228; GO:0001712; GO:0005634; GO:0005737; GO:0006357; GO:0030154; GO:0035019; GO:0045596; GO:0060644 0 0 0 PF00178;PF02198; Q5ZIJ9 CHOYP_MIB2.6.6 m.60718 sp MIB2_CHICK 32 650 392 14 68 701 176 791 3.19E-92 311 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q5ZKL6 CHOYP_MBOA2.1.1 m.26615 sp MBOA2_CHICK 39.535 473 275 4 10 472 7 478 3.19E-122 369 MBOA2_CHICK reviewed Membrane-bound O-acyltransferase domain-containing protein 2 (O-acyltransferase domain-containing protein 2) (EC 2.3.-.-) mboat2 oact2 RCJMB04_10b24 Gallus gallus (Chicken) 518 phospholipid biosynthetic process [GO:0008654] GO:0008654; GO:0016021; GO:0016746 PATHWAY: Lipid metabolism; phospholipid metabolism. 0 0 PF03062; Q6AZD1 CHOYP_BRAFLDRAFT_117858.2.3 m.48275 sp T179A_DANRE 31.532 222 145 4 8 225 7 225 3.19E-28 109 T179A_DANRE reviewed Transmembrane protein 179 tmem179 si:dkey-85n7.1 zgc:101058 Danio rerio (Zebrafish) (Brachydanio rerio) 232 0 GO:0016021 0 0 0 0 Q6P8D1 CHOYP_LOC100543980.2.2 m.34222 sp RSSA_XENTR 84 75 12 0 1 75 34 108 3.19E-40 137 RSSA_XENTR reviewed 40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) rpsa TNeu119p20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 306 "cell adhesion [GO:0007155]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; ribosomal small subunit assembly [GO:0000028]; rRNA export from nucleus [GO:0006407]; translation [GO:0006412]" GO:0000028; GO:0000447; GO:0000461; GO:0003735; GO:0005055; GO:0005634; GO:0005886; GO:0006407; GO:0006412; GO:0007155; GO:0022627; GO:0030686 0 0 cd01425; PF16122;PF00318; Q6PCD5 CHOYP_BRAFLDRAFT_121302.1.2 m.17968 sp RFWD3_HUMAN 44.158 505 256 10 240 729 280 773 3.19E-141 436 RFWD3_HUMAN reviewed E3 ubiquitin-protein ligase RFWD3 (EC 6.3.2.-) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) RFWD3 RNF201 Homo sapiens (Human) 774 DNA repair [GO:0006281]; mitophagy in response to mitochondrial depolarization [GO:0098779]; mitotic G1 DNA damage checkpoint [GO:0031571]; positive regulation of defense response to virus by host [GO:0002230]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; response to ionizing radiation [GO:0010212]; xenophagy [GO:0098792] GO:0002039; GO:0002230; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0008270; GO:0010212; GO:0016567; GO:0016605; GO:0016874; GO:0031571; GO:0097371; GO:0098779; GO:0098792; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q7T3E5 CHOYP_CCBL1.1.1 m.30637 sp KAT3_DANRE 44.656 421 226 4 1 418 32 448 3.19E-132 391 KAT3_DANRE reviewed Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) kyat3 ccbl2 kat3 zgc:63929 Danio rerio (Zebrafish) (Brachydanio rerio) 450 biosynthetic process [GO:0009058]; cellular amino acid metabolic process [GO:0006520]; kynurenine metabolic process [GO:0070189] GO:0006520; GO:0009058; GO:0016212; GO:0030170; GO:0047315; GO:0047804; GO:0070189 0 0 0 PF00155; Q86Z23 CHOYP_C1QL4.1.10 m.4152 sp C1QL4_HUMAN 30.612 147 85 5 152 291 100 236 3.19E-11 65.5 C1QL4_HUMAN reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8CDU4 CHOYP_LOC100372542.1.3 m.33376 sp FXL13_MOUSE 33.917 799 463 12 6 789 2 750 3.19E-153 469 FXL13_MOUSE reviewed F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13) Fbxl13 Mus musculus (Mouse) 790 0 0 0 0 0 PF12937;PF13516; Q8CG79 CHOYP_LOC100892387.1.1 m.15172 sp ASPP2_MOUSE 37.349 83 50 1 2 82 4 86 3.19E-11 63.2 ASPP2_MOUSE reviewed Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) Tp53bp2 Aspp2 Trp53bp2 Mus musculus (Mouse) 1128 cell cycle [GO:0007049]; central nervous system development [GO:0007417]; embryo development ending in birth or egg hatching [GO:0009792]; heart development [GO:0007507]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of execution phase of apoptosis [GO:1900119]; response to ionizing radiation [GO:0010212] GO:0002039; GO:0005634; GO:0005737; GO:0007049; GO:0007417; GO:0007507; GO:0009792; GO:0010212; GO:0042802; GO:0048471; GO:0051059; GO:0072332; GO:0097193; GO:1900119 0 0 0 PF12796;PF00018; Q8HYW0 CHOYP_FA13A.1.2 m.296 sp FA13A_BOVIN 33.797 503 232 18 571 1016 234 692 3.19E-57 214 FA13A_BOVIN reviewed Protein FAM13A (Protein Precm1) FAM13A FAM13A1 PRECM1 Bos taurus (Bovine) 697 0 0 0 0 0 0 Q8MP06 CHOYP_LOC579833.1.1 m.23271 sp SNO1_TYRJA 39.568 139 74 5 16 147 148 283 3.19E-20 88.6 SNO1_TYRJA reviewed Senecionine N-oxygenase (SNO) (EC 1.14.13.101) sno1 Tyria jacobaeae (Cinnabar moth) 456 alkaloid metabolic process [GO:0009820]; oxidation-reduction process [GO:0055114]; protein homotetramerization [GO:0051289] GO:0004499; GO:0005576; GO:0009820; GO:0033784; GO:0050660; GO:0050661; GO:0051289; GO:0055114 0 0 0 PF00743; Q8QZY6 CHOYP_PMTR.1.1 m.46450 sp TSN14_MOUSE 26.943 193 106 8 97 254 76 268 3.19E-08 58.5 TSN14_MOUSE reviewed Tetraspanin-14 (Tspan-14) (Transmembrane 4 superfamily member 14) Tspan14 D14Ertd226e Tm4sf14 Mus musculus (Mouse) 270 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005886; GO:0005887; GO:0007166; GO:0009986; GO:0019899; GO:0045747; GO:0051604; GO:0090002; GO:0097197 0 0 0 PF00335; Q8WY64 CHOYP_MYLIP.2.3 m.53543 sp MYLIP_HUMAN 43.084 441 236 6 6 437 1 435 3.19E-127 378 MYLIP_HUMAN reviewed E3 ubiquitin-protein ligase MYLIP (EC 6.3.2.-) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) MYLIP BZF1 IDOL BM-023 PP5242 Homo sapiens (Human) 445 cholesterol homeostasis [GO:0042632]; movement of cell or subcellular component [GO:0006928]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; nervous system development [GO:0007399]; positive regulation of protein catabolic process [GO:0045732]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of low-density lipoprotein particle receptor catabolic process [GO:0032803] GO:0000209; GO:0004842; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006928; GO:0007399; GO:0008092; GO:0008270; GO:0010989; GO:0016567; GO:0016874; GO:0019898; GO:0031648; GO:0032803; GO:0042632; GO:0042787; GO:0045732; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF09380;PF00373;PF09379; Q8WY64 CHOYP_MYLIP.3.3 m.59439 sp MYLIP_HUMAN 43.084 441 236 6 6 437 1 435 3.19E-127 378 MYLIP_HUMAN reviewed E3 ubiquitin-protein ligase MYLIP (EC 6.3.2.-) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) MYLIP BZF1 IDOL BM-023 PP5242 Homo sapiens (Human) 445 cholesterol homeostasis [GO:0042632]; movement of cell or subcellular component [GO:0006928]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; nervous system development [GO:0007399]; positive regulation of protein catabolic process [GO:0045732]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of low-density lipoprotein particle receptor catabolic process [GO:0032803] GO:0000209; GO:0004842; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006928; GO:0007399; GO:0008092; GO:0008270; GO:0010989; GO:0016567; GO:0016874; GO:0019898; GO:0031648; GO:0032803; GO:0042632; GO:0042787; GO:0045732; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF09380;PF00373;PF09379; Q8WZ60 CHOYP_KLH13.1.1 m.45400 sp KLHL6_HUMAN 31.633 98 66 1 14 110 197 294 3.19E-08 58.5 KLHL6_HUMAN reviewed Kelch-like protein 6 KLHL6 Homo sapiens (Human) 621 B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467] GO:0002467; GO:0050853 0 0 0 PF07707;PF00651;PF01344; Q96M34 CHOYP_BRAFLDRAFT_120244.2.2 m.57616 sp CC030_HUMAN 51.163 43 21 0 64 106 494 536 3.19E-10 59.3 CC030_HUMAN reviewed Uncharacterized protein C3orf30 C3orf30 Homo sapiens (Human) 536 0 0 0 0 0 0 Q9BYN7 CHOYP_ZN341.1.1 m.11022 sp ZN341_HUMAN 52 500 188 8 247 711 297 779 3.19E-174 531 ZN341_HUMAN reviewed Zinc finger protein 341 ZNF341 Homo sapiens (Human) 854 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q9DAK3 CHOYP_RHBT1.1.1 m.53865 sp RHBT1_MOUSE 37.775 683 397 12 8 669 8 683 3.19E-140 429 RHBT1_MOUSE reviewed Rho-related BTB domain-containing protein 1 Rhobtb1 Mus musculus (Mouse) 695 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF00651;PF00071; Q9ESN6 CHOYP_CCDC112.1.1 m.382 sp TRIM2_MOUSE 24.479 192 137 5 278 463 555 744 3.19E-06 53.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H8W5 CHOYP_LOC100373444.61.79 m.55741 sp TRI45_HUMAN 26.396 197 124 5 15 197 135 324 3.19E-11 69.7 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9NZJ4 CHOYP_SACS.13.17 m.57228 sp SACS_HUMAN 28.457 1121 676 40 111 1150 96 1171 3.19E-74 275 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9ULI3 CHOYP_LOC100366953.1.1 m.3655 sp HEG1_HUMAN 38.356 73 33 2 483 555 993 1053 3.19E-08 61.6 HEG1_HUMAN reviewed Protein HEG homolog 1 HEG1 KIAA1237 Homo sapiens (Human) 1381 cardiac atrium morphogenesis [GO:0003209]; cardiac muscle tissue growth [GO:0055017]; cell-cell junction assembly [GO:0007043]; endothelial cell morphogenesis [GO:0001886]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; lymph circulation [GO:0003017]; lymph vessel development [GO:0001945]; multicellular organism growth [GO:0035264]; pericardium development [GO:0060039]; positive regulation of fibroblast growth factor production [GO:0090271]; post-embryonic development [GO:0009791]; regulation of body fluid levels [GO:0050878]; vasculogenesis [GO:0001570]; venous blood vessel morphogenesis [GO:0048845]; ventricular septum development [GO:0003281]; ventricular trabecula myocardium morphogenesis [GO:0003222] GO:0001570; GO:0001701; GO:0001886; GO:0001945; GO:0003017; GO:0003209; GO:0003222; GO:0003281; GO:0005509; GO:0005576; GO:0005911; GO:0007043; GO:0009791; GO:0009897; GO:0016021; GO:0030324; GO:0035264; GO:0048845; GO:0050878; GO:0055017; GO:0060039; GO:0090271 0 0 0 PF00008;PF07645; A4IF63 CHOYP_RNF138.1.1 m.55038 sp TRIM2_BOVIN 44.262 61 29 2 2 57 5 65 3.20E-08 54.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7SG73 CHOYP_LOC100183583.1.2 m.3864 sp NADC_NEMVE 68.59 156 49 0 1 156 101 256 3.20E-74 226 NADC_NEMVE reviewed Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (Fragment) qprt v1g117116 Nematostella vectensis (Starlet sea anemone) 289 NAD biosynthetic process [GO:0009435]; quinolinate catabolic process [GO:0034213] GO:0004514; GO:0005737; GO:0009435; GO:0034213 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1. 0 0 PF01729;PF02749; D2GXS7 CHOYP_BRAFLDRAFT_109857.7.15 m.32723 sp TRIM2_AILME 25.6 250 172 5 27 265 498 744 3.20E-13 72.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_245347.1.1 m.14303 sp TRIM2_AILME 26.257 179 96 6 4 146 525 703 3.20E-06 48.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O62640 CHOYP_IAP1.3.4 m.55361 sp PIAP_PIG 31.273 275 164 5 1164 1423 91 355 3.20E-41 159 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; O94913 CHOYP_PCF11.1.1 m.49191 sp PCF11_HUMAN 38.689 305 161 7 1547 1842 1267 1554 3.20E-54 213 PCF11_HUMAN reviewed Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11) PCF11 KIAA0824 Homo sapiens (Human) 1555 "mRNA 3'-end processing [GO:0031124]; mRNA cleavage [GO:0006379]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000398; GO:0000993; GO:0003729; GO:0005654; GO:0005737; GO:0005849; GO:0006369; GO:0006378; GO:0006379; GO:0031124 0 0 0 PF04818; O95847 CHOYP_UCP4.1.1 m.11449 sp UCP4_HUMAN 56.338 213 87 2 21 227 22 234 3.20E-80 249 UCP4_HUMAN reviewed Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27) SLC25A27 UCP4 UNQ772/PRO1566 Homo sapiens (Human) 323 generation of precursor metabolites and energy [GO:0006091]; proton transport [GO:0015992]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005743; GO:0006091; GO:0006412; GO:0015992; GO:0016021 0 0 0 PF00153; P09645 CHOYP_AAEL_AAEL013229.1.2 m.30363 sp TBA8_CHICK 98.925 93 1 0 1 93 188 280 3.20E-66 204 TBA8_CHICK reviewed Tubulin alpha-8 chain (Fragment) 0 Gallus gallus (Chicken) 324 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P10079 CHOYP_LOC100634060.34.37 m.65888 sp FBP1_STRPU 55.556 225 100 0 1 225 322 546 3.20E-71 237 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10253 CHOYP_LYAG.2.2 m.30233 sp LYAG_HUMAN 54.857 175 79 0 1 175 463 637 3.20E-65 218 LYAG_HUMAN reviewed Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase] GAA Homo sapiens (Human) 952 cardiac muscle contraction [GO:0060048]; diaphragm contraction [GO:0002086]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; heart morphogenesis [GO:0003007]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; maltose metabolic process [GO:0000023]; muscle cell cellular homeostasis [GO:0046716]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; regulation of the force of heart contraction [GO:0002026]; sucrose metabolic process [GO:0005985]; tissue development [GO:0009888]; vacuolar sequestering [GO:0043181] GO:0000023; GO:0002026; GO:0002086; GO:0003007; GO:0004558; GO:0004574; GO:0005764; GO:0005765; GO:0005980; GO:0005985; GO:0006006; GO:0007040; GO:0007626; GO:0009888; GO:0016020; GO:0030246; GO:0032450; GO:0043181; GO:0043202; GO:0046716; GO:0050884; GO:0050885; GO:0060048; GO:0070062 0 0 cd00111; PF13802;PF01055;PF16863;PF00088; P24032 CHOYP_LOC100882621.1.2 m.25863 sp MLRN_CHICK 84.354 147 23 0 1 147 1 147 3.20E-85 251 MLRN_CHICK reviewed "Myosin regulatory light chain 2, smooth muscle minor isoform (MLC-2) (DTNB) (G1) (Isoform L20-B1)" 0 Gallus gallus (Chicken) 172 0 GO:0005509; GO:0016459 0 0 0 PF13499;PF13833; P46209 CHOYP_NEMVEDRAFT_V1G164392.1.3 m.46942 sp USF_AQUPY 34.359 195 110 7 32 215 27 214 3.20E-24 99.4 USF_AQUPY reviewed Protein usf usf Aquifex pyrophilus 231 0 GO:0016787 0 0 0 PF01738; P50123 CHOYP_APN.3.3 m.60028 sp AMPE_RAT 38.542 672 392 11 32 691 60 722 3.20E-158 484 AMPE_RAT reviewed Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (CD antigen CD249) Enpep Rattus norvegicus (Rat) 945 angiotensin maturation [GO:0002003]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cellular aromatic compound metabolic process [GO:0006725]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081] GO:0002003; GO:0003081; GO:0004177; GO:0005737; GO:0005886; GO:0006508; GO:0006725; GO:0008217; GO:0008270; GO:0008283; GO:0012506; GO:0016021; GO:0016477; GO:0031983; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; P55214 CHOYP_CASP2.2.5 m.17468 sp CASP7_MESAU 31.902 163 83 3 105 264 60 197 3.20E-15 79.7 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q01085 CHOYP_YTDC1.2.2 m.57722 sp TIAR_HUMAN 54.264 258 102 4 1 257 68 310 3.20E-88 271 TIAR_HUMAN reviewed Nucleolysin TIAR (TIA-1-related protein) TIAL1 Homo sapiens (Human) 375 apoptotic process [GO:0006915]; defense response [GO:0006952]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ cell development [GO:0007281]; positive regulation of cell proliferation [GO:0008284]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; stem cell division [GO:0017145] GO:0000166; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0006357; GO:0006915; GO:0006952; GO:0007281; GO:0008284; GO:0008543; GO:0010494; GO:0017091; GO:0017145; GO:0044822; GO:0070062 0 0 0 PF00076; Q03601 CHOYP_LOC100367973.2.3 m.50099 sp NHL1_CAEEL 26.119 134 85 5 11 139 36 160 3.20E-10 61.6 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q05695 CHOYP_LAD-2.1.1 m.53499 sp L1CAM_RAT 23.474 426 293 13 48 458 52 459 3.20E-24 111 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q05A80 CHOYP_C1QL2.20.32 m.38946 sp CAPR2_MOUSE 34.559 136 79 5 255 384 897 1028 3.20E-12 71.6 CAPR2_MOUSE reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) 1031 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q08705 CHOYP_LOC100905908.1.1 m.15272 sp CTCF_CHICK 58.363 281 115 2 328 606 266 546 3.20E-110 358 CTCF_CHICK reviewed Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) CTCF Gallus gallus (Chicken) 728 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q12718 CHOYP_LOC100206475.9.16 m.46461 sp LAC2_TRAVE 30.233 602 292 21 76 650 18 518 3.20E-60 214 LAC2_TRAVE reviewed Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Laccase I) (Urishiol oxidase 2) LCC2 LCCI Trametes versicolor (White-rot fungus) (Coriolus versicolor) 519 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q14444 CHOYP_LOC100376767.1.1 m.49888 sp CAPR1_HUMAN 45.178 197 103 1 20 216 54 245 3.20E-48 171 CAPR1_HUMAN reviewed Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105 Homo sapiens (Human) 709 negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003] GO:0000932; GO:0003723; GO:0005737; GO:0005829; GO:0005887; GO:0010494; GO:0016020; GO:0017148; GO:0030425; GO:0044822; GO:0050775; GO:0061003 0 0 0 PF12287; Q28HY5 CHOYP_CP072.1.1 m.51720 sp CP072_XENTR 46.909 275 120 9 2 268 9 265 3.20E-67 212 CP072_XENTR reviewed UPF0472 protein C16orf72 homolog TEgg029f10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 265 0 0 0 0 0 PF15251; Q28HY5 CHOYP_PHUM_PHUM536560.2.2 m.59368 sp CP072_XENTR 46.909 275 120 9 2 268 9 265 3.20E-67 212 CP072_XENTR reviewed UPF0472 protein C16orf72 homolog TEgg029f10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 265 0 0 0 0 0 PF15251; Q4LDE5 CHOYP_LOC100367084.4.22 m.30436 sp SVEP1_HUMAN 26.221 389 212 9 27 350 728 1106 3.20E-20 101 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5M9H0 CHOYP_ANKS3.1.1 m.35086 sp ANKS3_RAT 58.182 330 127 7 10 335 3 325 3.20E-112 360 ANKS3_RAT reviewed Ankyrin repeat and SAM domain-containing protein 3 Anks3 Rattus norvegicus (Rat) 663 0 0 0 0 0 PF12796;PF00536; Q5SVQ8 CHOYP_AAEL_AAEL000292.1.1 m.19085 sp ZBT41_HUMAN 43.86 57 32 0 221 277 696 752 3.20E-09 60.8 ZBT41_HUMAN reviewed Zinc finger and BTB domain-containing protein 41 ZBTB41 FRBZ1 Homo sapiens (Human) 909 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF13912; Q5ZJV7 CHOYP_PHUM_PHUM561630.1.1 m.12012 sp FA60A_CHICK 49.772 219 90 3 1 213 1 205 3.20E-64 204 FA60A_CHICK reviewed Protein FAM60A FAM60A RCJMB04_15g2 Gallus gallus (Chicken) 222 negative regulation of cell migration [GO:0030336] GO:0016580; GO:0030336 0 0 0 PF15396; Q6DHQ1 CHOYP_HVCN1.2.4 m.29334 sp HVCN1_DANRE 28.358 134 91 3 191 323 104 233 3.20E-10 63.5 HVCN1_DANRE reviewed Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) hvcn1 zgc:92181 Danio rerio (Zebrafish) (Brachydanio rerio) 235 cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transport [GO:0015992] GO:0005887; GO:0015992; GO:0030171; GO:0071294; GO:0071467 0 0 0 PF00520; Q6PBF0 CHOYP_RL8.1.10 m.6792 sp RL8_XENTR 81.641 256 47 0 15 270 1 256 3.20E-155 435 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q8C525 CHOYP_LOC100377311.3.14 m.21738 sp M21D2_MOUSE 24.832 149 104 4 51 198 181 322 3.20E-07 55.5 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8TBZ2 CHOYP_MYBPP.1.1 m.45264 sp MYBPP_HUMAN 25.547 548 373 13 114 635 91 629 3.20E-38 157 MYBPP_HUMAN reviewed MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1) MYCBPAP AMAP1 Homo sapiens (Human) 947 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0007268; GO:0007275; GO:0007283; GO:0016020; GO:0030154 0 0 0 PF14646; Q96D21 CHOYP_PHUM_PHUM468090.1.1 m.29790 sp RHES_HUMAN 51.351 259 115 6 54 310 17 266 3.20E-81 249 RHES_HUMAN reviewed GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2) RASD2 TEM2 Homo sapiens (Human) 266 "locomotory behavior [GO:0007626]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein sumoylation [GO:0033235]; regulation of cAMP-mediated signaling [GO:0043949]; small GTPase mediated signal transduction [GO:0007264]; synaptic transmission, dopaminergic [GO:0001963]" GO:0001963; GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0007626; GO:0031397; GO:0031681; GO:0033235; GO:0043949; GO:0051897 0 0 0 PF00071; Q96JP2 CHOYP_LOC100901924.2.3 m.55058 sp MY15B_HUMAN 36.184 304 179 7 185 480 1206 1502 3.20E-51 194 MY15B_HUMAN reviewed Unconventional myosin-XVB (Myosin XVBP) (Unconventional myosin-15B) MYO15B KIAA1783 MYO15BP Homo sapiens (Human) 1530 0 GO:0003774; GO:0005524; GO:0005737; GO:0016459 0 0 0 PF00063;PF00784;PF07653; Q96MM6 CHOYP_BRAFLDRAFT_208293.15.20 m.61604 sp HS12B_HUMAN 32.71 642 343 15 17 596 54 668 3.20E-97 314 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99315 CHOYP_contig_006625 m.7538 sp YG31B_YEAST 31.698 795 473 19 78 860 586 1322 3.20E-108 380 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9D826 CHOYP_LOC100673983.1.1 m.10072 sp SOX_MOUSE 50.66 379 181 4 2 376 6 382 3.20E-128 376 SOX_MOUSE reviewed Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) Pipox Pso Mus musculus (Mouse) 390 L-lysine catabolic process to acetyl-CoA via L-pipecolate [GO:0033514]; oxidation-reduction process [GO:0055114]; tetrahydrofolate metabolic process [GO:0046653] GO:0005102; GO:0005777; GO:0008115; GO:0033514; GO:0046653; GO:0050031; GO:0055114 0 0 0 PF01266; Q9NFP5 CHOYP_SH3L1.2.5 m.9176 sp SH3BG_DROME 45.283 106 50 2 1 99 1 105 3.20E-24 100 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9R1R2 CHOYP_contig_029010 m.32946 sp TRIM3_MOUSE 27.049 122 83 3 179 297 625 743 3.20E-06 52.4 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y264 CHOYP_BRAFLDRAFT_125263.9.9 m.66988 sp ANGP4_HUMAN 34.466 206 115 5 57 245 200 402 3.20E-29 119 ANGP4_HUMAN reviewed Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) ANGPT4 ANG3 ANG4 Homo sapiens (Human) 503 angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] GO:0001525; GO:0005576; GO:0005615; GO:0007219; GO:0010595; GO:0016525; GO:0030297; GO:0030971; GO:0043066; GO:0043536; GO:0043537; GO:0045766; GO:0050731; GO:0050900; GO:0071456 0 0 0 PF00147; Q9Y4A0 CHOYP_BRAFLDRAFT_211054.1.3 m.37335 sp JERKL_HUMAN 23.651 241 148 9 121 342 121 344 3.20E-10 66.6 JERKL_HUMAN reviewed Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG) JRKL Homo sapiens (Human) 524 central nervous system development [GO:0007417] GO:0003677; GO:0005634; GO:0007417 0 0 0 PF04218;PF03184;PF03221; G3V9D0 CHOYP_POGLUT1.1.1 m.45796 sp PGLT1_RAT 63.788 359 127 3 40 396 23 380 3.21E-177 501 PGLT1_RAT reviewed Protein O-glucosyltransferase 1 (EC 2.4.1.-) (O-glucosyltransferase Rumi homolog) (Protein O-xylosyltransferase) (EC 2.4.2.26) Poglut1 Rattus norvegicus (Rat) 392 glycolipid metabolic process [GO:0006664]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked glycosylation [GO:0006493] GO:0005788; GO:0006493; GO:0006664; GO:0030158; GO:0035251; GO:0035252; GO:0045747 PATHWAY: Protein modification; protein glycosylation. 0 0 PF05686; P61023 CHOYP_CHP1.2.2 m.50161 sp CHP1_RAT 69.898 196 52 2 1 190 1 195 3.21E-92 270 CHP1_RAT reviewed Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22) Chp1 Chp Rattus norvegicus (Rat) 195 calcium ion regulated exocytosis [GO:0017156]; calcium-mediated signaling [GO:0019722]; cellular response to acidic pH [GO:0071468]; cytoplasmic microtubule organization [GO:0031122]; membrane docking [GO:0022406]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; microtubule bundle formation [GO:0001578]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein transport [GO:0051222]; positive regulation of sodium:proton antiporter activity [GO:0032417]; protein export from nucleus [GO:0006611]; protein oligomerization [GO:0051259]; protein stabilization [GO:0050821]; regulation of intracellular pH [GO:0051453]; regulation of neuron death [GO:1901214] GO:0000139; GO:0001578; GO:0001933; GO:0004860; GO:0005215; GO:0005509; GO:0005634; GO:0005737; GO:0005783; GO:0005793; GO:0005829; GO:0005886; GO:0005925; GO:0006469; GO:0006611; GO:0008017; GO:0010923; GO:0015630; GO:0017156; GO:0019722; GO:0019900; GO:0022406; GO:0030133; GO:0031122; GO:0031397; GO:0031953; GO:0032088; GO:0032417; GO:0042308; GO:0048306; GO:0050821; GO:0051222; GO:0051259; GO:0051453; GO:0060050; GO:0061024; GO:0061025; GO:0070062; GO:0070885; GO:0071468; GO:0090314; GO:1901214 0 0 0 PF13499; Q0EEE2 CHOYP_LOC100372915.4.7 m.32231 sp PTHD3_MOUSE 26.389 432 284 11 19 431 84 500 3.21E-41 160 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q0P5N6 CHOYP_LOC583422.1.1 m.36955 sp ARL16_HUMAN 42.442 172 93 2 1 168 25 194 3.21E-40 137 ARL16_HUMAN reviewed ADP-ribosylation factor-like protein 16 ARL16 Homo sapiens (Human) 197 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF00025; Q5RGJ8 CHOYP_GNPTA.3.3 m.54938 sp GNPTA_DANRE 48.883 403 187 8 1 391 330 725 3.21E-126 395 GNPTA_DANRE reviewed N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein gnptab) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] gnptab gnpta si:ch211-234f20.3 zgc:122985 Danio rerio (Zebrafish) (Brachydanio rerio) 1219 carbohydrate phosphorylation [GO:0046835]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic viscerocranium morphogenesis [GO:0048703]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256] GO:0000139; GO:0002063; GO:0003976; GO:0005509; GO:0005794; GO:0007040; GO:0016021; GO:0016256; GO:0046835; GO:0048701; GO:0048703; GO:0051216 0 0 0 PF06464;PF00066;PF17101;PF11380;PF17102;PF17103; Q5RJY2 CHOYP_BRAFLDRAFT_247017.1.1 m.64509 sp G2E3_MOUSE 44.404 277 150 3 24 298 14 288 3.21E-83 288 G2E3_MOUSE reviewed G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) G2e3 Kiaa1333 Mus musculus (Mouse) 716 apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0001824; GO:0005730; GO:0005737; GO:0006915; GO:0008270; GO:0016874; GO:0061630; GO:2001243 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q5XKA2 CHOYP_LOC100647975.2.2 m.46555 sp TIM21_XENLA 46.309 149 77 2 92 237 84 232 3.21E-40 140 TIM21_XENLA reviewed "Mitochondrial import inner membrane translocase subunit Tim21 (TIM21-like protein, mitochondrial)" timm21 tim21 Xenopus laevis (African clawed frog) 232 protein import into mitochondrial matrix [GO:0030150] GO:0005744; GO:0016021; GO:0030150 0 0 0 PF08294; Q6P4Z2 CHOYP_FL2D.1.1 m.62440 sp CO2A1_XENTR 48.649 185 95 0 76 260 692 876 3.21E-23 102 CO2A1_XENTR reviewed Collagen alpha-1(II) chain (Alpha-1 type II collagen) col2a1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1492 0 GO:0005201; GO:0005578; GO:0005581; GO:0046872 0 0 0 PF01410;PF01391;PF00093; Q6P4Z2 CHOYP_LOC100121674.1.1 m.62648 sp CO2A1_XENTR 48.649 185 95 0 76 260 692 876 3.21E-23 102 CO2A1_XENTR reviewed Collagen alpha-1(II) chain (Alpha-1 type II collagen) col2a1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1492 0 GO:0005201; GO:0005578; GO:0005581; GO:0046872 0 0 0 PF01410;PF01391;PF00093; Q6R7G0 CHOYP_YG31B.1.3 m.6175 sp Y068_OSHVF 21.795 546 358 15 37 521 155 692 3.21E-28 124 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q75N90 CHOYP_BRAFLDRAFT_98740.7.7 m.65348 sp FBN3_HUMAN 32.523 987 504 48 253 1152 449 1360 3.21E-85 314 FBN3_HUMAN reviewed Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide] FBN3 KIAA1776 Homo sapiens (Human) 2809 anatomical structure morphogenesis [GO:0009653]; regulation of cellular response to growth factor stimulus [GO:0090287] GO:0005201; GO:0005509; GO:0005578; GO:0009653; GO:0031012; GO:0090287 0 0 0 PF12662;PF07645;PF12661;PF00683; Q7LHG5 CHOYP_LOC100888562.1.1 m.9287 sp YI31B_YEAST 38.868 265 161 1 183 446 610 874 3.21E-58 211 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q86U90 CHOYP_NEMVEDRAFT_V1G161176.1.1 m.29830 sp YRDC_HUMAN 51.777 197 93 1 35 229 73 269 3.21E-66 209 YRDC_HUMAN reviewed "YrdC domain-containing protein, mitochondrial (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP)" YRDC DRIP3 IRIP Homo sapiens (Human) 279 negative regulation of transport [GO:0051051]; regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949] GO:0000049; GO:0002949; GO:0003725; GO:0005737; GO:0005739; GO:0006450; GO:0016020; GO:0016779; GO:0051051 0 0 0 PF01300; Q8BUG5 CHOYP_LOC579381.1.1 m.10900 sp CAYP2_MOUSE 36.542 509 289 10 164 655 59 550 3.21E-96 309 CAYP2_MOUSE reviewed Calcyphosin-2 (Calcyphosine-2) Caps2 Mus musculus (Mouse) 550 0 GO:0005509 0 0 0 0 Q8JHV9 CHOYP_PC2.1.2 m.34944 sp BIR7A_XENLA 29.054 444 235 11 524 966 36 400 3.21E-50 186 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8NI08 CHOYP_LOC655529.1.3 m.1225 sp NCOA7_HUMAN 49.045 314 141 5 431 738 641 941 3.21E-91 308 NCOA7_HUMAN reviewed Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 Homo sapiens (Human) 942 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005622; GO:0005634; GO:0006351; GO:0030374; GO:0035257; GO:0045944 0 0 0 PF01476;PF07534; Q96P44 CHOYP_OTO1A.1.1 m.30921 sp COLA1_HUMAN 43.256 215 91 4 24 214 441 648 3.21E-24 105 COLA1_HUMAN reviewed Collagen alpha-1(XXI) chain COL21A1 COL1AL FP633 Homo sapiens (Human) 957 0 GO:0005576; GO:0005578; GO:0005581; GO:0005788 0 0 0 PF01391;PF00092; Q9JI70 CHOYP_LOC581756.1.1 m.7461 sp MKKS_MOUSE 28.752 553 380 4 25 571 26 570 3.21E-66 228 MKKS_MOUSE reviewed McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (Protein Bbs6 homolog) Mkks Bbs6 Mus musculus (Mouse) 570 artery smooth muscle contraction [GO:0014824]; brain morphogenesis [GO:0048854]; cartilage development [GO:0051216]; cerebral cortex development [GO:0021987]; chaperone-mediated protein complex assembly [GO:0051131]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; face development [GO:0060324]; fat cell differentiation [GO:0045444]; hippocampus development [GO:0021766]; leptin-mediated signaling pathway [GO:0033210]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of appetite by leptin-mediated signaling pathway [GO:0038108]; negative regulation of blood pressure [GO:0045776]; negative regulation of gene expression [GO:0010629]; negative regulation of GTPase activity [GO:0034260]; nonmotile primary cilium assembly [GO:0035058]; photoreceptor cell maintenance [GO:0045494]; positive regulation of multicellular organism growth [GO:0040018]; protein folding [GO:0006457]; regulation of cilium beat frequency involved in ciliary motility [GO:0060296]; regulation of stress fiber assembly [GO:0051492]; response to leptin [GO:0044321]; sensory perception of smell [GO:0007608]; social behavior [GO:0035176]; spermatid development [GO:0007286]; striatum development [GO:0021756]; vasodilation [GO:0042311] GO:0001103; GO:0005524; GO:0005622; GO:0005813; GO:0005829; GO:0006457; GO:0007286; GO:0007608; GO:0010629; GO:0014824; GO:0021756; GO:0021766; GO:0021987; GO:0030837; GO:0031514; GO:0033210; GO:0034260; GO:0035058; GO:0035176; GO:0036064; GO:0038108; GO:0040018; GO:0042311; GO:0042384; GO:0044321; GO:0045444; GO:0045494; GO:0045776; GO:0048854; GO:0050910; GO:0051131; GO:0051216; GO:0051492; GO:0060271; GO:0060296; GO:0060324; GO:1902636 0 0 0 PF00118; Q9R0W9 CHOYP_LOAG_04698.2.2 m.55867 sp ACHA6_MOUSE 33.333 483 309 5 69 546 10 484 3.21E-98 310 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9R1R2 CHOYP_LOC100368020.4.29 m.13472 sp TRIM3_MOUSE 30.657 137 89 3 56 190 110 242 3.21E-08 58.9 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UIF8 CHOYP_BRAFLDRAFT_122791.2.6 m.11364 sp BAZ2B_HUMAN 40.748 535 277 10 494 991 731 1262 3.21E-107 387 BAZ2B_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00439;PF02791;PF01429;PF00628;PF15613; B1ANS9 CHOYP_LOC582771.1.1 m.35494 sp WDR64_HUMAN 38.904 712 387 12 12 709 9 686 3.22E-164 520 WDR64_HUMAN reviewed WD repeat-containing protein 64 WDR64 Homo sapiens (Human) 1081 0 0 0 0 0 PF00400; D2GXS7 CHOYP_BRAFLDRAFT_241726.16.22 m.33152 sp TRIM2_AILME 28.704 108 75 1 43 148 627 734 3.22E-07 52 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D8VNT0 CHOYP_LOC100639086.1.1 m.61770 sp FCNV4_CERRY 41.081 185 97 5 100 283 129 302 3.22E-37 139 FCNV4_CERRY reviewed Ryncolin-4 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; G5E8K5 CHOYP_LOC100374409.1.2 m.423 sp ANK3_MOUSE 29.885 261 155 5 41 301 479 711 3.22E-24 109 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O13356 CHOYP_LOC100641628.2.3 m.54331 sp CHS1_CRYNH 34.815 135 70 4 931 1049 585 717 3.22E-11 71.6 CHS1_CRYNH reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) (Class-IV chitin synthase 1) CHS1 CNAG_03099 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 1236 cell wall organization [GO:0071555] GO:0004100; GO:0005886; GO:0016021; GO:0071555 0 0 0 0 O43557 CHOYP_TBB.5.7 m.60063 sp TNF14_HUMAN 31.724 145 83 8 171 311 108 240 3.22E-11 65.5 TNF14_HUMAN reviewed "Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]" TNFSF14 HVEML LIGHT UNQ391/PRO726 Homo sapiens (Human) 240 apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of T cell chemotaxis [GO:0010820]; release of cytoplasmic sequestered NF-kappaB [GO:0008588]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0005102; GO:0005615; GO:0005737; GO:0005886; GO:0006915; GO:0006955; GO:0007165; GO:0008588; GO:0010820; GO:0016021; GO:0031295; GO:0033209; GO:0042098; GO:0042110; GO:0043027; GO:0043029; GO:0045663; GO:0071260; GO:1901741 0 0 0 PF00229; P05400 CHOYP_LOC100486317.1.5 m.22247 sp POL_CERV 22.014 427 284 11 137 549 259 650 3.22E-11 69.7 POL_CERV reviewed Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Carnation etched ring virus (CERV) 659 0 GO:0003964; GO:0004190; GO:0004519 0 0 0 PF02160;PF00078; P53013 CHOYP_LOC100118048.1.1 m.62638 sp EF1A_CAEEL 66.421 271 74 4 1 263 201 462 3.22E-117 346 EF1A_CAEEL reviewed Elongation factor 1-alpha (EF-1-alpha) eft-3 F31E3.5; eft-4 R03G5.1 Caenorhabditis elegans 463 embryo development ending in birth or egg hatching [GO:0009792]; growth [GO:0040007] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0008135; GO:0009792; GO:0040007 0 0 0 PF03144;PF03143; Q09388 CHOYP_LOC100646264.1.1 m.55636 sp ACM2_CAEEL 42.857 245 137 3 46 288 5 248 3.22E-58 210 ACM2_CAEEL reviewed Probable muscarinic acetylcholine receptor gar-2 (G-protein-linked acetylcholine receptor 2) gar-2 F47D12.1/F47D12.2 Caenorhabditis elegans 627 "G-protein coupled receptor signaling pathway [GO:0007186]; synaptic transmission, cholinergic [GO:0007271]" GO:0005887; GO:0007186; GO:0007271; GO:0016907 0 0 0 PF00001; Q32KR8 CHOYP_BRAFLDRAFT_212086.6.11 m.52833 sp ADPRH_BOVIN 55.556 162 71 1 9 169 191 352 3.22E-50 172 ADPRH_BOVIN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Bos taurus (Bovine) 353 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q3KPT0 CHOYP_LOC100375592.6.6 m.63433 sp CC169_XENLA 53.846 78 36 0 17 94 17 94 3.22E-19 84.7 CC169_XENLA reviewed Coiled-coil domain-containing protein 169 ccdc169 Xenopus laevis (African clawed frog) 214 0 0 0 0 0 PF15372; Q3TCX3 CHOYP_LOC100374968.1.1 m.13396 sp K0907_MOUSE 52.874 261 112 4 50 302 71 328 3.22E-73 257 K0907_MOUSE reviewed UPF0469 protein KIAA0907 Kiaa0907 Mus musculus (Mouse) 612 0 GO:0003723; GO:0005634 0 0 0 0 Q460N5 CHOYP_PARP14.15.22 m.52655 sp PAR14_HUMAN 38.205 390 225 8 3 391 1426 1800 3.22E-67 234 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q54KA7 CHOYP_AFUA_1G01020.4.50 m.14038 sp SECG_DICDI 37.56 418 257 4 86 499 66 483 3.22E-63 225 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5I0K7 CHOYP_LOC100692071.1.1 m.594 sp ALG13_RAT 53.988 163 70 3 20 179 5 165 3.22E-55 174 ALG13_RAT reviewed UDP-N-acetylglucosamine transferase subunit ALG13 homolog (EC 2.4.1.141) (Glycosyltransferase 28 domain-containing protein 1) Alg13 Glt28d1 Rattus norvegicus (Rat) 165 0 GO:0004577; GO:0005783 0 0 0 PF04101; Q5RBX7 CHOYP_ISCW_ISCW012442.1.1 m.8441 sp SRP14_PONAB 62.376 101 36 1 25 123 1 101 3.22E-40 134 SRP14_PONAB reviewed Signal recognition particle 14 kDa protein (SRP14) SRP14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 136 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005786; GO:0006614; GO:0008312; GO:0030942 0 0 0 PF02290; Q5RJ80 CHOYP_C1QL4L.3.7 m.5967 sp CAPR2_DANRE 36.62 142 76 9 43 176 776 911 3.22E-13 70.9 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5RJ80 CHOYP_LOC101158517.1.3 m.19326 sp CAPR2_DANRE 36.62 142 76 9 43 176 776 911 3.22E-13 70.9 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5RJ80 CHOYP_SMP_023240.3.3 m.64830 sp CAPR2_DANRE 29.71 138 87 5 48 177 776 911 3.22E-07 52.8 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q68EZ3 CHOYP_LOC101168501.1.1 m.5535 sp ANM6_XENLA 60.256 156 62 0 62 217 14 169 3.22E-65 207 ANM6_XENLA reviewed Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT6) prmt6 Xenopus laevis (African clawed frog) 340 "DNA repair [GO:0006281]; histone H3-R2 methylation [GO:0034970]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006281; GO:0006351; GO:0019919; GO:0034970; GO:0035241; GO:0035242; GO:0042054; GO:0042393; GO:0044020; GO:0045892; GO:0070611; GO:0070612 0 0 0 PF05185; Q6PFY8 CHOYP_LOC100378898.8.10 m.55174 sp TRI45_MOUSE 33.981 206 110 8 5 195 127 321 3.22E-16 85.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7L1 CHOYP_OSHV1_GP010.1.2 m.28855 sp Y012_OSHVF 98.974 195 2 0 1 195 1 195 3.22E-140 391 Y012_OSHVF reviewed Uncharacterized protein ORF12 ORF12 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 195 0 0 0 0 0 0 Q6R7L1 CHOYP_OSHV1_GP010.2.2 m.30532 sp Y012_OSHVF 98.974 195 2 0 1 195 1 195 3.22E-140 391 Y012_OSHVF reviewed Uncharacterized protein ORF12 ORF12 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 195 0 0 0 0 0 0 Q7TNS2 CHOYP_BRAFLDRAFT_283990.1.4 m.2163 sp MIC10_MOUSE 58.065 62 26 0 27 88 2 63 3.22E-20 80.5 MIC10_MOUSE reviewed MICOS complex subunit Mic10 (Mitochondrial inner membrane organizing system protein 1) Minos1 Mic10 Mus musculus (Mouse) 76 0 GO:0005739; GO:0005743; GO:0016021 0 0 0 PF04418; Q7ZYR8 CHOYP_RSRC2.1.1 m.14844 sp RSRC2_XENLA 50.993 151 65 5 352 500 199 342 3.22E-31 127 RSRC2_XENLA reviewed Arginine/serine-rich coiled-coil protein 2 rsrc2 Xenopus laevis (African clawed frog) 350 0 0 0 0 0 PF15477; Q8NAG6 CHOYP_ISCW_ISCW011180.1.1 m.45187 sp ANKL1_HUMAN 48.473 262 117 4 451 704 361 612 3.22E-67 235 ANKL1_HUMAN reviewed Ankyrin repeat and LEM domain-containing protein 1 (Ankyrin repeat domain-containing protein 41) (LEM-domain containing protein 3) ANKLE1 ANKRD41 LEM3 Homo sapiens (Human) 615 0 0 0 0 0 PF12796;PF03020; Q8NE09 CHOYP_TRIADDRAFT_64391.3.3 m.54562 sp RGS22_HUMAN 36.458 96 55 1 1163 1258 1045 1134 3.22E-12 75.5 RGS22_HUMAN reviewed Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) 1264 negative regulation of signal transduction [GO:0009968] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0009968 0 0 0 PF00615; Q8R040 CHOYP_LOC100367243.1.1 m.36883 sp RPP21_MOUSE 31.068 103 69 2 27 128 12 113 3.22E-12 63.2 RPP21_MOUSE reviewed Ribonuclease P protein subunit p21 (RNaseP protein p21) (EC 3.1.26.5) (Ribonucleoprotein V) Rpp21 Cat60 Mus musculus (Mouse) 150 response to drug [GO:0042493]; tRNA processing [GO:0008033] GO:0004526; GO:0005655; GO:0008033; GO:0042493; GO:0046872 0 0 0 PF04032; Q96J01 CHOYP_BRAFLDRAFT_128129.1.1 m.63237 sp THOC3_HUMAN 73.041 319 83 2 40 357 35 351 3.22E-178 501 THOC3_HUMAN reviewed THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) THOC3 Homo sapiens (Human) 351 mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; viral mRNA export from host cell nucleus [GO:0046784] GO:0000346; GO:0000445; GO:0003723; GO:0005654; GO:0006369; GO:0006405; GO:0006406; GO:0008380; GO:0016607; GO:0031124; GO:0046784 0 0 0 PF12894;PF08662;PF00400; Q96RW7 CHOYP_HMCN1.11.44 m.28595 sp HMCN1_HUMAN 47.034 236 125 0 119 354 4633 4868 3.22E-70 245 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9FGH2 CHOYP_NEMVEDRAFT_V1G220156.3.3 m.53990 sp LSH5_ARATH 34.862 109 64 2 201 308 44 146 3.22E-12 67.8 LSH5_ARATH reviewed Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 5 (Protein ORGAN BOUNDARY 5) LSH5 OBO5 At5g58500 MQJ2.11 Arabidopsis thaliana (Mouse-ear cress) 182 "mRNA transcription [GO:0009299]; post-embryonic morphogenesis [GO:0009886]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0009299; GO:0009886 0 0 0 PF04852; Q9H1J1 CHOYP_BRAFLDRAFT_70868.1.1 m.55081 sp REN3A_HUMAN 51.176 170 72 3 24 190 68 229 3.22E-43 165 REN3A_HUMAN reviewed Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) UPF3A RENT3A UPF3 Homo sapiens (Human) 476 "mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]" GO:0000166; GO:0000184; GO:0003723; GO:0005487; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0042162; GO:0043231; GO:0045727; GO:0051028 0 0 0 PF03467; Q9JLC8 CHOYP_SACS.1.17 m.3737 sp SACS_MOUSE 26.087 437 258 18 36 416 4153 4580 3.22E-21 100 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9NTG1 CHOYP_TRIADDRAFT_53596.1.1 m.47642 sp PKDRE_HUMAN 25.63 1151 686 33 1059 2089 1104 2204 3.22E-90 332 PKDRE_HUMAN reviewed Polycystic kidney disease and receptor for egg jelly-related protein (PKD and REJ homolog) PKDREJ Homo sapiens (Human) 2253 acrosome reaction [GO:0007340]; detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0007340; GO:0016020; GO:0016021; GO:0050982 0 0 0 PF08016;PF01477;PF02010; Q9QXK2 CHOYP_RAD18.1.1 m.56266 sp RAD18_MOUSE 38.696 230 125 3 16 242 143 359 3.22E-38 149 RAD18_MOUSE reviewed E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-) (Postreplication repair protein RAD18) (mRAD18Sc) Rad18 Rad18sc Mus musculus (Mouse) 509 cellular response to DNA damage stimulus [GO:0006974]; negative regulation of cell death [GO:0060548]; negative regulation of DNA recombination [GO:0045910]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; response to UV [GO:0009411]; spermatogenesis [GO:0007283] GO:0000403; GO:0000785; GO:0001741; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005813; GO:0006301; GO:0006513; GO:0006974; GO:0007283; GO:0008270; GO:0009411; GO:0016874; GO:0031593; GO:0031625; GO:0032403; GO:0035861; GO:0042405; GO:0042802; GO:0043142; GO:0045910; GO:0051865; GO:0051984; GO:0060548; GO:0061630; GO:0097505 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02037; Q9WV92 CHOYP_LOC100373842.1.4 m.2290 sp E41L3_MOUSE 58.529 340 135 4 4 342 120 454 3.22E-135 439 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; O00625 CHOYP_PIR.1.1 m.48663 sp PIR_HUMAN 63.028 284 103 2 59 341 4 286 3.23E-132 384 PIR_HUMAN reviewed "Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)" PIR Homo sapiens (Human) 290 "monocyte differentiation [GO:0030224]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003712; GO:0005634; GO:0005737; GO:0006355; GO:0006366; GO:0008127; GO:0030224; GO:0046872 PATHWAY: Flavonoid metabolism; quercetin degradation. 0 0 PF02678;PF05726; O95786 CHOYP_IFIH1.8.14 m.53649 sp DDX58_HUMAN 28.571 315 181 14 456 749 37 328 3.23E-13 77 DDX58_HUMAN reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) DDX58 Homo sapiens (Human) 925 cytoplasmic pattern recognition receptor signaling pathway in response to virus [GO:0039528]; detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; regulation of type III interferon production [GO:0034344]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0034344; GO:0039528; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944; GO:0051091 0 0 0 PF16739;PF00270;PF00271;PF11648; P04179 CHOYP_SODM.1.2 m.45531 sp SODM_HUMAN 63.182 220 79 2 6 224 2 220 3.23E-102 298 SODM_HUMAN reviewed "Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)" SOD2 Homo sapiens (Human) 222 age-dependent response to reactive oxygen species [GO:0001315]; negative regulation of cell proliferation [GO:0008285]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; oxygen homeostasis [GO:0032364]; protein homotetramerization [GO:0051289]; regulation of blood pressure [GO:0008217]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; release of cytochrome c from mitochondria [GO:0001836]; removal of superoxide radicals [GO:0019430]; response to reactive oxygen species [GO:0000302]; response to superoxide [GO:0000303]; superoxide metabolic process [GO:0006801]; vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [GO:0003069] GO:0000302; GO:0000303; GO:0001315; GO:0001836; GO:0003069; GO:0004784; GO:0005739; GO:0005759; GO:0006357; GO:0006801; GO:0008217; GO:0008285; GO:0019430; GO:0030145; GO:0032364; GO:0042802; GO:0043524; GO:0051289; GO:0070062; GO:1902176 0 0 0 PF02777;PF00081; P37397 CHOYP_SMP_078690.3.5 m.2272 sp CNN3_RAT 43.827 162 83 5 3 160 114 271 3.23E-25 104 CNN3_RAT reviewed "Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform)" Cnn3 Rattus norvegicus (Rat) 330 actomyosin structure organization [GO:0031032]; epithelial cell differentiation [GO:0030855]; negative regulation of ATPase activity [GO:0032780] GO:0005737; GO:0005874; GO:0005884; GO:0005925; GO:0008017; GO:0014069; GO:0030425; GO:0030674; GO:0030855; GO:0031032; GO:0032780; GO:0043025; GO:0043197 0 0 0 PF00402;PF00307; Q01484 CHOYP_LOC578974.10.11 m.61388 sp ANK2_HUMAN 31.122 784 457 5 386 1099 43 813 3.23E-108 377 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q02763 CHOYP_TIE2.4.6 m.47268 sp TIE2_HUMAN 27.856 499 293 16 887 1362 642 1096 3.23E-45 182 TIE2_HUMAN reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 Homo sapiens (Human) 1124 angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; leukocyte migration [GO:0050900]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; organ regeneration [GO:0031100]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000165; GO:0001525; GO:0001666; GO:0001934; GO:0001935; GO:0001938; GO:0001958; GO:0002040; GO:0004672; GO:0004713; GO:0004714; GO:0004872; GO:0005088; GO:0005524; GO:0005576; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007165; GO:0007169; GO:0007267; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016323; GO:0016324; GO:0016525; GO:0018108; GO:0031100; GO:0032878; GO:0034446; GO:0043066; GO:0043114; GO:0043434; GO:0043552; GO:0043627; GO:0045121; GO:0045766; GO:0046777; GO:0048014; GO:0050728; GO:0050900; GO:0051259; GO:0051591; GO:0051894; GO:0051897; GO:0060216; GO:0060347; GO:0070374; GO:0072012; GO:1902533; GO:2000251; GO:2000351; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q05609 CHOYP_CTR1.2.4 m.39987 sp CTR1_ARATH 35.275 309 178 10 388 691 514 805 3.23E-39 158 CTR1_ARATH reviewed Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1) CTR1 At5g03730 F17C15_150 Arabidopsis thaliana (Mouse-ear cress) 821 cellular response to iron ion [GO:0071281]; ethylene-activated signaling pathway [GO:0009873]; gibberellin biosynthetic process [GO:0009686]; negative regulation of ethylene-activated signaling pathway [GO:0010105]; protein autophosphorylation [GO:0046777]; regulation of post-embryonic root development [GO:2000069]; regulation of stem cell division [GO:2000035]; regulation of timing of transition from vegetative to reproductive phase [GO:0048510]; response to ethylene [GO:0009723]; response to fructose [GO:0009750]; response to hypoxia [GO:0001666]; response to sucrose [GO:0009744]; sugar mediated signaling pathway [GO:0010182] GO:0001666; GO:0004674; GO:0004712; GO:0005524; GO:0005789; GO:0009686; GO:0009723; GO:0009744; GO:0009750; GO:0009873; GO:0010105; GO:0010182; GO:0046777; GO:0048510; GO:0071281; GO:2000035; GO:2000069 0 0 0 PF07714; Q0P6D2 CHOYP_LOC100021542.1.1 m.9103 sp FA69C_HUMAN 29.771 393 237 13 32 412 48 413 3.23E-45 164 FA69C_HUMAN reviewed Protein FAM69C FAM69C C18orf51 Homo sapiens (Human) 419 0 GO:0005789; GO:0016021 0 0 0 PF12260;PF14875; Q12767 CHOYP_LOC100123810.1.2 m.8024 sp TMM94_HUMAN 39.427 454 247 7 461 905 922 1356 3.23E-88 310 TMM94_HUMAN reviewed Transmembrane protein 94 TMEM94 KIAA0195 Homo sapiens (Human) 1356 0 GO:0005654; GO:0016021 0 0 0 PF00689; Q1L8P7 CHOYP_LINJ_18_1030.3.4 m.42639 sp TSP3B_DANRE 39.456 147 70 5 66 202 431 568 3.23E-08 56.2 TSP3B_DANRE reviewed Thrombospondin-3b (Thbs3b) thbs3b si:dkey-81h8.2 Danio rerio (Zebrafish) (Brachydanio rerio) 929 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0007155; GO:0008201 0 0 0 PF11598;PF07645;PF02412;PF05735; Q1ZXD6 CHOYP_BRAFLDRAFT_129004.11.15 m.45864 sp ROCO5_DICDI 37.079 89 37 5 418 504 1340 1411 3.23E-06 54.7 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q2TBG9 CHOYP_LOC100372743.1.1 m.38540 sp TM169_BOVIN 48.305 118 61 0 97 214 153 270 3.23E-35 129 TM169_BOVIN reviewed Transmembrane protein 169 TMEM169 Bos taurus (Bovine) 297 0 GO:0016021 0 0 0 PF15052; Q3UTQ8 CHOYP_CDKL5.1.1 m.29285 sp CDKL5_MOUSE 76.431 297 70 0 1 297 10 306 3.23E-165 513 CDKL5_MOUSE reviewed Cyclin-dependent kinase-like 5 (EC 2.7.11.22) Cdkl5 Mus musculus (Mouse) 938 neuron migration [GO:0001764]; positive regulation of axon extension [GO:0045773]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of GTPase activity [GO:0043547]; protein autophosphorylation [GO:0046777] GO:0001764; GO:0004672; GO:0004693; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0016301; GO:0032587; GO:0032839; GO:0043547; GO:0044294; GO:0045773; GO:0046777; GO:0050775 0 0 0 PF00069; Q5RD69 CHOYP_AGAP_AGAP005942.1.3 m.3157 sp TICN3_PONAB 48.333 60 29 1 81 138 316 375 3.23E-09 59.3 TICN3_PONAB reviewed "Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)" SPOCK3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 436 signal transduction [GO:0007165] GO:0005509; GO:0005578; GO:0007165; GO:0008191 0 0 0 PF07648;PF10591;PF00086; Q5U3Y0 CHOYP_KLD10.1.1 m.8960 sp KLD10_RAT 45.143 350 188 3 35 380 60 409 3.23E-113 339 KLD10_RAT reviewed Kelch domain-containing protein 10 Klhdc10 Rattus norvegicus (Rat) 410 0 GO:0005634; GO:0005737 0 0 0 PF01344; Q5UQP2 CHOYP_LOC584119.1.1 m.27726 sp YL446_MIMIV 34.896 192 114 6 68 256 55 238 3.23E-20 95.1 YL446_MIMIV reviewed Uncharacterized protein L446 (EC 3.1.1.-) MIMI_L446 Acanthamoeba polyphaga mimivirus (APMV) 332 lipid catabolic process [GO:0016042] GO:0016021; GO:0016042; GO:0016787 0 0 0 PF01734; Q5XGP7 CHOYP_SKA2A.3.3 m.56921 sp SKA2A_XENLA 38.136 118 65 2 9 119 99 215 3.23E-16 83.6 SKA2A_XENLA reviewed Src kinase-associated phosphoprotein 2-A skap2-a Xenopus laevis (African clawed frog) 330 B cell activation [GO:0042113] GO:0005737; GO:0042113 0 0 0 PF00169;PF00018; Q6AYR9 CHOYP_LOC101157895.2.2 m.28009 sp TSN1_RAT 25.114 219 144 7 12 228 4 204 3.23E-08 56.6 TSN1_RAT reviewed Tetraspanin-1 (Tspan-1) Tspan1 Rattus norvegicus (Rat) 241 cell migration [GO:0016477]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of endocytosis [GO:0045807]; protein stabilization [GO:0050821] GO:0005765; GO:0005887; GO:0007166; GO:0008283; GO:0016477; GO:0045807; GO:0048471; GO:0050821; GO:0070062 0 0 0 PF00335; Q6DFV8 CHOYP_BRAFLDRAFT_80496.10.10 m.60407 sp VWDE_MOUSE 22.514 533 320 21 86 548 411 920 3.23E-20 100 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q92543 CHOYP_SNX19.1.1 m.34570 sp SNX19_HUMAN 29.773 440 259 12 443 835 527 963 3.23E-48 188 SNX19_HUMAN reviewed Sorting nexin-19 SNX19 KIAA0254 Homo sapiens (Human) 992 chondrocyte differentiation [GO:0002062]; dense core granule maturation [GO:1990502]; exocytosis [GO:0006887]; insulin secretion [GO:0030073] GO:0002062; GO:0005737; GO:0006887; GO:0030073; GO:0030659; GO:0031901; GO:0032266; GO:1990502 0 0 0 PF08628;PF00787;PF02194; Q93134 CHOYP_LOC101079003.1.1 m.39304 sp GBLP_BIOGL 83.436 163 27 0 1 163 1 163 3.23E-98 289 GBLP_BIOGL reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) 0 Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) 316 0 0 0 0 0 PF00400; Q96PZ2 CHOYP_F111A.2.2 m.18504 sp F111A_HUMAN 27.737 274 150 14 502 752 334 582 3.23E-10 67 F111A_HUMAN reviewed Protein FAM111A FAM111A KIAA1895 Homo sapiens (Human) 611 defense response to virus [GO:0051607]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071] GO:0000785; GO:0005634; GO:0005737; GO:0006260; GO:0045071; GO:0051607 0 0 0 0 Q99M80 CHOYP_PTPRD.2.3 m.51175 sp PTPRT_MOUSE 30.015 683 435 13 75 720 774 1450 3.23E-87 303 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_99973.3.8 m.33121 sp TRIM2_MOUSE 27.039 233 141 10 104 320 486 705 3.23E-10 64.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9VNL4 CHOYP_DANA_GF18626.1.1 m.61228 sp GRCR1_DROME 42.731 227 128 1 106 330 228 454 3.23E-66 218 GRCR1_DROME reviewed Glutaredoxin domain-containing cysteine-rich protein CG31559 CG31559 Drosophila melanogaster (Fruit fly) 454 cell redox homeostasis [GO:0045454] GO:0005623; GO:0009055; GO:0015035; GO:0045454 0 0 0 PF00462; Q9VTP4 CHOYP_R10AB.2.2 m.66920 sp R10AB_DROME 69.466 131 40 0 1 131 63 193 3.23E-50 163 R10AB_DROME reviewed 60S ribosomal protein L10a-2 RpL10Ab CG7283 Drosophila melanogaster (Fruit fly) 217 centrosome duplication [GO:0051298]; maturation of LSU-rRNA [GO:0000470]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; translation [GO:0006412] GO:0000022; GO:0000470; GO:0003723; GO:0003735; GO:0006412; GO:0007052; GO:0022625; GO:0051298 0 0 cd00403; PF00687; Q9Y4R7 CHOYP_LOC578867.4.5 m.48706 sp TTLL3_HUMAN 52.291 371 173 4 617 984 179 548 3.23E-128 415 TTLL3_HUMAN reviewed Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) 772 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; protein polyglycylation [GO:0018094] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0035082; GO:0042384; GO:0070735; GO:0070736 0 0 0 PF03133; A1A5K6 CHOYP_LOC100120644.1.1 m.28338 sp TBC24_XENLA 41.038 212 84 2 37 208 339 549 3.24E-49 171 TBC24_XENLA reviewed TBC1 domain family member 24 tbc1d24 Xenopus laevis (African clawed frog) 562 0 GO:0005096 0 0 0 PF00566;PF07534; A4UTQ2 CHOYP_EF1A2.2.3 m.37041 sp BTG3_PIG 51.786 112 54 0 1 112 1 112 3.24E-37 137 BTG3_PIG reviewed Protein BTG3 (BTG family member 3) BTG3 Sus scrofa (Pig) 252 negative regulation of mitotic cell cycle [GO:0045930] GO:0005737; GO:0045930 0 0 0 PF07742; B3EWZ3 CHOYP_SSPO.4.14 m.5533 sp CADN_ACRMI 37.162 148 76 3 77 207 369 516 3.24E-21 95.9 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; E9Q555 CHOYP_LOC100377154.1.4 m.36665 sp RN213_MOUSE 22.892 498 331 17 95 561 909 1384 3.24E-21 102 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 G5E8K5 CHOYP_CRE_19274.1.1 m.6846 sp ANK3_MOUSE 31.596 307 179 6 48 348 463 744 3.24E-35 144 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; H2A0M7 CHOYP_PLSP.2.5 m.40533 sp PLSP_PINMG 42.75 669 314 17 2 629 60 700 3.24E-140 430 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O95948 CHOYP_ONEC2.1.3 m.22857 sp ONEC2_HUMAN 48.941 425 131 13 73 452 105 488 3.24E-109 335 ONEC2_HUMAN reviewed One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) ONECUT2 HNF6B Homo sapiens (Human) 504 cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cilium assembly [GO:0042384]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; organ morphogenesis [GO:0009887]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell migration [GO:0030335]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952] GO:0000978; GO:0001077; GO:0001889; GO:0001952; GO:0002064; GO:0005634; GO:0005654; GO:0009887; GO:0015629; GO:0030154; GO:0030335; GO:0030512; GO:0031018; GO:0042384; GO:0045165; GO:0045944; GO:0048935 0 0 0 PF02376;PF00046; P04792 CHOYP_CRYAB.2.5 m.23201 sp HSPB1_HUMAN 38.667 75 43 2 49 121 95 168 3.24E-11 61.2 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P08133 CHOYP_ANXA6.2.2 m.62703 sp ANXA6_HUMAN 26.907 721 451 11 228 934 12 670 3.24E-83 285 ANXA6_HUMAN reviewed Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70) ANXA6 ANX6 Homo sapiens (Human) 673 apoptotic signaling pathway [GO:0097190]; calcium ion transport [GO:0006816]; ion transmembrane transport [GO:0034220]; mitochondrial calcium ion homeostasis [GO:0051560]; protein homooligomerization [GO:0051260]; regulation of muscle contraction [GO:0006937] GO:0005509; GO:0005525; GO:0005544; GO:0005634; GO:0005739; GO:0005765; GO:0005925; GO:0006816; GO:0006937; GO:0008289; GO:0014704; GO:0015276; GO:0015485; GO:0016020; GO:0016324; GO:0031902; GO:0034220; GO:0042383; GO:0042470; GO:0042803; GO:0043234; GO:0048306; GO:0048471; GO:0051260; GO:0051560; GO:0070062; GO:0097190 0 0 0 PF00191; P11503 CHOYP_BRAFLDRAFT_114843.2.2 m.57238 sp HSP70_ONCVO 87.692 130 16 0 1 130 167 296 3.24E-79 239 HSP70_ONCVO reviewed Heat shock 70 kDa protein (HSP70) (Fragment) 0 Onchocerca volvulus 322 0 GO:0005524 0 0 0 PF00012; P16157 CHOYP_LOC100640442.4.10 m.33053 sp ANK1_HUMAN 29.885 783 454 28 210 932 19 766 3.24E-62 234 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P56654 CHOYP_WNT2B.2.3 m.37823 sp CP237_MOUSE 38.65 489 287 7 1 481 5 488 3.24E-111 340 CP237_MOUSE reviewed Cytochrome P450 2C37 (EC 1.14.14.1) (CYPIIC37) Cyp2c37 Mus musculus (Mouse) 490 epoxygenase P450 pathway [GO:0019373] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019373; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P98164 CHOYP_LRP2.3.7 m.13790 sp LRP2_HUMAN 27.36 625 353 20 351 939 3891 4450 3.24E-50 198 LRP2_HUMAN reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) 4655 aorta development [GO:0035904]; cell proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; endocytosis [GO:0006897]; forebrain development [GO:0030900]; lipid metabolic process [GO:0006629]; protein glycosylation [GO:0006486]; receptor-mediated endocytosis [GO:0006898]; retinoid metabolic process [GO:0001523]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359] GO:0001523; GO:0003281; GO:0005041; GO:0005509; GO:0005764; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005905; GO:0006486; GO:0006629; GO:0006897; GO:0006898; GO:0008283; GO:0016021; GO:0016324; GO:0030139; GO:0030900; GO:0031526; GO:0035904; GO:0042359; GO:0042954; GO:0043235; GO:0060976; GO:0070062 0 0 0 PF12662;PF07645;PF00057;PF00058; Q0P464 CHOYP_MTHSD.1.2 m.36416 sp MTHSD_DANRE 64.516 186 66 0 1 186 81 266 3.24E-79 253 MTHSD_DANRE reviewed Methenyltetrahydrofolate synthase domain-containing protein mthfsd zgc:153374 Danio rerio (Zebrafish) (Brachydanio rerio) 382 0 GO:0000166; GO:0003723 0 0 0 PF01812; Q18932 CHOYP_CAH10.1.2 m.35885 sp CAH2_CAEEL 36.9 271 156 6 56 313 16 284 3.24E-59 196 CAH2_CAEEL reviewed Putative carbonic anhydrase-like protein 2 cah-2 D1022.8 Caenorhabditis elegans 337 0 GO:0005576 0 0 0 PF00194; Q4A3R3 CHOYP_BRAFLDRAFT_120139.5.5 m.59973 sp DMBT1_PIG 38.01 392 197 14 2 361 113 490 3.24E-51 197 DMBT1_PIG reviewed Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) 1204 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0007275; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0035375; GO:0042589 0 0 0 PF00431;PF00530;PF00100; Q4KKZ1 CHOYP_LOC100368360.1.1 m.9672 sp CA158_MOUSE 38.365 159 97 1 6 163 10 168 3.24E-31 116 CA158_MOUSE reviewed Uncharacterized protein C1orf158 homolog 0 Mus musculus (Mouse) 196 0 0 0 0 0 0 Q5EA43 CHOYP_LOC100113883.1.1 m.8245 sp SFXN2_BOVIN 52.5 320 146 4 7 326 9 322 3.24E-104 311 SFXN2_BOVIN reviewed Sideroflexin-2 SFXN2 Bos taurus (Bovine) 322 iron ion homeostasis [GO:0055072] GO:0015075; GO:0016021; GO:0031966; GO:0055072 0 0 0 PF03820; Q5ZIJ0 CHOYP_BUD13.1.1 m.12311 sp BUD13_CHICK 34.737 95 52 4 4 93 6 95 3.24E-08 52.8 BUD13_CHICK reviewed BUD13 homolog BUD13 RCJMB04_25m15 Gallus gallus (Chicken) 559 0 0 0 0 0 PF09736; Q6AY22 CHOYP_LOC100374267.5.5 m.63830 sp SPAT1_RAT 38.624 189 109 4 413 600 247 429 3.24E-29 124 SPAT1_RAT reviewed Spermatogenesis-associated protein 1 Spata1 Rattus norvegicus (Rat) 444 0 0 0 0 0 PF15743; Q6E2N3 CHOYP_AGAP_AGAP002344.1.1 m.35267 sp TRI33_DANRE 25.89 309 196 13 3 292 123 417 3.24E-12 72.8 TRI33_DANRE reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) 1163 "embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; fin development [GO:0033333]; post-embryonic hemopoiesis [GO:0035166]; primitive hemopoiesis [GO:0060215]; protein ubiquitination [GO:0016567]; regulation of transcription elongation from RNA polymerase II promoter [GO:0034243]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0030218; GO:0033333; GO:0034243; GO:0035162; GO:0035166; GO:0060215 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643; Q6NSJ5 CHOYP_LOC100162005.1.1 m.42983 sp LRC8E_HUMAN 35.714 98 61 1 111 208 660 755 3.24E-10 65.5 LRC8E_HUMAN reviewed Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E) LRRC8E Homo sapiens (Human) 796 anion transmembrane transport [GO:0098656] GO:0005225; GO:0005737; GO:0005789; GO:0005886; GO:0005887; GO:0098656 0 0 0 PF13855;PF12534; Q6P2X9 CHOYP_NEMVEDRAFT_V1G240018.1.1 m.54076 sp MOT12_XENTR 32.323 297 159 11 37 302 14 299 3.24E-26 110 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6ZR08 CHOYP_DYH12.1.1 m.38560 sp DYH12_HUMAN 65.018 283 97 2 1 282 2796 3077 3.24E-120 384 DYH12_HUMAN reviewed "Dynein heavy chain 12, axonemal (Axonemal beta dynein heavy chain 12) (Axonemal dynein heavy chain 12-like protein) (Axonemal dynein heavy chain 7-like protein) (Ciliary dynein heavy chain 12) (Dynein heavy chain 7-like, axonemal) (Dynein heavy chain domain-containing protein 2)" DNAH12 DHC3 DLP12 DNAH12L DNAH7L DNAHC3 DNHD2 HDHC3 HL19 Homo sapiens (Human) 3092 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0007018; GO:0016887; GO:0030286 0 0 0 PF07728;PF12780;PF08393;PF03028; Q71RS6 CHOYP_LOC100883998.1.1 m.32370 sp NCKX5_HUMAN 40.167 478 269 3 56 533 38 498 3.24E-129 389 NCKX5_HUMAN reviewed Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5) SLC24A5 JSX NCKX5 Homo sapiens (Human) 500 cellular calcium ion homeostasis [GO:0006874]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; negative regulation of melanin biosynthetic process [GO:0048022]; response to stimulus [GO:0050896] GO:0005262; GO:0005509; GO:0005802; GO:0006811; GO:0006874; GO:0008273; GO:0015293; GO:0016021; GO:0030955; GO:0031402; GO:0032588; GO:0034220; GO:0042470; GO:0048022; GO:0050896 0 0 0 PF01699; Q80TQ5 CHOYP_BRAFLDRAFT_121069.1.1 m.23763 sp PKHM2_MOUSE 33.409 440 256 8 564 991 574 988 3.24E-74 268 PKHM2_MOUSE reviewed Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) Plekhm2 Kiaa0842 Mus musculus (Mouse) 1018 Golgi organization [GO:0007030]; lysosome localization [GO:0032418]; positive regulation of membrane tubulation [GO:1903527]; regulation of protein localization [GO:0032880] GO:0007030; GO:0010008; GO:0019894; GO:0032418; GO:0032880; GO:1903527 0 0 0 PF00169;PF02759; Q8IWZ3 CHOYP_LOC578679.5.6 m.53152 sp ANKH1_HUMAN 34.475 467 278 13 276 728 236 688 3.24E-50 199 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8N0N3 CHOYP_LOC100889837.1.2 m.2516 sp BGBP_PENMO 39.169 337 177 12 127 446 33 358 3.24E-64 214 BGBP_PENMO reviewed "Beta-1,3-glucan-binding protein (GBP)" 0 Penaeus monodon (Giant tiger prawn) 366 carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087] GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087 0 0 0 PF00722; Q90835 CHOYP_EF1A.1.4 m.10413 sp EF1A_CHICK 46.681 452 237 2 1 449 9 459 3.24E-147 436 EF1A_CHICK reviewed Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) EEF1A Gallus gallus (Chicken) 462 cellular response to epidermal growth factor stimulus [GO:0071364] GO:0000049; GO:0003746; GO:0003924; GO:0005525; GO:0005615; GO:0005622; GO:0005730; GO:0005829; GO:0030864; GO:0032587; GO:0043209; GO:0044822; GO:0070062; GO:0071364 0 0 0 PF03144;PF03143; Q91VA3 CHOYP_LOC100709493.1.2 m.34277 sp CAN8_MOUSE 33.918 513 288 19 222 691 30 534 3.24E-65 234 CAN8_MOUSE reviewed Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) Capn8 Ncl2 Mus musculus (Mouse) 703 digestion [GO:0007586]; proteolysis [GO:0006508] GO:0004198; GO:0005509; GO:0005737; GO:0005794; GO:0006508; GO:0007586 0 0 0 PF01067;PF00648; Q967D7 CHOYP_BRAFLDRAFT_203195.1.1 m.62959 sp TUTL_DROME 33.862 378 228 6 1 362 187 558 3.24E-63 221 TUTL_DROME reviewed Protein turtle tutl CG15427 Drosophila melanogaster (Fruit fly) 1531 adult locomotory behavior [GO:0008344]; axonal defasciculation [GO:0007414]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite self-avoidance [GO:0070593]; flight behavior [GO:0007629]; larval behavior [GO:0030537]; lateral inhibition [GO:0046331]; mechanosensory behavior [GO:0007638]; R7 cell development [GO:0045467]; regulation of dendrite morphogenesis [GO:0048814]; sensory perception of pain [GO:0019233]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007411; GO:0007414; GO:0007629; GO:0007638; GO:0008039; GO:0008344; GO:0016199; GO:0019233; GO:0030537; GO:0045467; GO:0046331; GO:0048814; GO:0070593; GO:0098632 0 0 0 PF00041;PF07679;PF07686; Q96M86 CHOYP_BRAFLDRAFT_102423.1.2 m.31628 sp DNHD1_HUMAN 28.386 539 346 11 1 529 83 591 3.24E-57 214 DNHD1_HUMAN reviewed Dynein heavy chain domain-containing protein 1 (Dynein heavy chain domain 1-like protein) (Protein CCDC35) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) 4753 microtubule-based movement [GO:0007018] GO:0003777; GO:0007018; GO:0030286; GO:0070062 0 0 0 PF08393;PF03028;PF12777; Q96MM6 CHOYP_HSPA12A.5.27 m.21251 sp HS12B_HUMAN 33.652 627 350 10 6 572 61 681 3.24E-107 340 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96QF7 CHOYP_LOC100878100.1.1 m.6666 sp ACRC_HUMAN 45.509 167 91 0 874 1040 511 677 3.24E-48 187 ACRC_HUMAN reviewed Acidic repeat-containing protein ACRC Homo sapiens (Human) 691 0 GO:0005634 0 0 0 PF10263; Q99996 CHOYP_LOC100368547.4.40 m.3180 sp AKAP9_HUMAN 50 54 27 0 73 126 3584 3637 3.24E-07 51.6 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9BMX5 CHOYP_RS6.6.12 m.26081 sp RS6_APLCA 88.889 99 11 0 1 99 101 199 3.24E-56 177 RS6_APLCA reviewed 40S ribosomal protein S6 RPS6 Aplysia californica (California sea hare) 247 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01092; Q9ERG0 CHOYP_LOC100877689.1.2 m.14376 sp LIMA1_MOUSE 47.009 117 59 2 780 894 356 471 3.24E-25 115 LIMA1_MOUSE reviewed LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN) Lima1 D15Ertd366e Eplin Mus musculus (Mouse) 753 actin filament bundle assembly [GO:0051017]; negative regulation of actin filament depolymerization [GO:0030835]; ruffle organization [GO:0031529] GO:0001725; GO:0003785; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0008270; GO:0015629; GO:0030835; GO:0031529; GO:0032154; GO:0051015; GO:0051017 0 0 0 PF00412; Q9NUV9 CHOYP_GIMA7.3.4 m.49498 sp GIMA4_HUMAN 36.533 323 186 6 72 381 11 327 3.24E-61 203 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; A1L4H1 CHOYP_BRAFLDRAFT_68917.2.3 m.28554 sp SRCRL_HUMAN 52.475 101 48 0 192 292 771 871 3.25E-29 120 SRCRL_HUMAN reviewed Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D) SSC5D Homo sapiens (Human) 1573 defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; negative regulation of interleukin-8 secretion [GO:2000483] GO:0001968; GO:0005044; GO:0005615; GO:0005622; GO:0005737; GO:0007275; GO:0016020; GO:0031012; GO:0042494; GO:0043236; GO:0045087; GO:0050829; GO:0050830; GO:0050840; GO:2000483 0 0 0 PF00530; A4IF63 CHOYP_BRAFLDRAFT_206799.9.23 m.32610 sp TRIM2_BOVIN 24.342 152 111 3 18 166 593 743 3.25E-07 53.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D9HP19 CHOYP_CTTB2.2.2 m.21806 sp CNR3_MAIZE 37.143 105 57 2 4 99 31 135 3.25E-15 70.1 CNR3_MAIZE reviewed Cell number regulator 3 (ZmCNR03) CNR3 Zea mays (Maize) 167 0 GO:0016021 0 0 0 PF04749; I3LM39 CHOYP_MB21D1.5.5 m.58554 sp CGAS_PIG 25.722 381 231 14 129 478 107 466 3.25E-21 100 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O46339 CHOYP_MEIS2.3.4 m.12432 sp HTH_DROME 69.697 132 35 3 12 140 340 469 3.25E-51 176 HTH_DROME reviewed Homeobox protein homothorax (Homeobox protein dorsotonals) hth dtl CG17117 Drosophila melanogaster (Fruit fly) 487 "brain development [GO:0007420]; compound eye development [GO:0048749]; compound eye photoreceptor fate commitment [GO:0001752]; eye development [GO:0001654]; haltere morphogenesis [GO:0048735]; head morphogenesis [GO:0060323]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing morphogenesis [GO:0007476]; leg disc proximal/distal pattern formation [GO:0007479]; peripheral nervous system development [GO:0007422]; positive regulation of decapentaplegic signaling pathway [GO:0090098]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein import into nucleus, translocation [GO:0000060]; protein localization to nucleus [GO:0034504]; proximal/distal pattern formation [GO:0009954]; regulation of cell fate specification [GO:0042659]; regulation of neuron differentiation [GO:0045664]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; salivary gland boundary specification [GO:0007432]; segmentation [GO:0035282]; somatic muscle development [GO:0007525]; specification of organ identity [GO:0010092]; specification of segmental identity, antennal segment [GO:0007383]; specification of segmental identity, head [GO:0007380]" GO:0000060; GO:0001654; GO:0001752; GO:0003677; GO:0003700; GO:0003705; GO:0005634; GO:0005667; GO:0005737; GO:0005829; GO:0006357; GO:0007380; GO:0007383; GO:0007420; GO:0007422; GO:0007432; GO:0007476; GO:0007479; GO:0007480; GO:0007525; GO:0008134; GO:0009954; GO:0010092; GO:0034504; GO:0035282; GO:0035326; GO:0042659; GO:0045664; GO:0045944; GO:0048735; GO:0048749; GO:0060323; GO:0090098 0 0 0 PF05920;PF16493; P04323 CHOYP_contig_002857 m.3181 sp POL3_DROME 41.875 160 93 0 9 168 296 455 3.25E-40 148 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P09118 CHOYP_URIC.1.2 m.35940 sp URIC_RAT 46.277 188 97 1 43 230 120 303 3.25E-56 184 URIC_RAT reviewed Uricase (EC 1.7.3.3) (Urate oxidase) Uox Rattus norvegicus (Rat) 303 allantoin biosynthetic process [GO:0019428]; purine nucleobase catabolic process [GO:0006145]; urate catabolic process [GO:0019628] GO:0004846; GO:0005739; GO:0005777; GO:0005782; GO:0006145; GO:0019428; GO:0019628 PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3. 0 0 PF01014; P16157 CHOYP_TVAG_451090.5.13 m.32874 sp ANK1_HUMAN 37.218 266 167 0 1 266 232 497 3.25E-48 174 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P29190 CHOYP_PCK-1.1.1 m.1481 sp PCKG_HAECO 66.667 129 43 0 30 158 35 163 3.25E-57 191 PCKG_HAECO reviewed Phosphoenolpyruvate carboxykinase [GTP] (PEPCK) (EC 4.1.1.32) PEPCK Haemonchus contortus (Barber pole worm) 619 gluconeogenesis [GO:0006094] GO:0004613; GO:0005525; GO:0006094; GO:0046872 0 0 0 PF00821; P36975 CHOYP_LOC100533400.4.4 m.66339 sp SNP25_DROME 61.326 181 65 2 18 196 15 192 3.25E-72 221 SNP25_DROME reviewed Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) Snap25 CG40452 Drosophila melanogaster (Fruit fly) 212 Golgi to plasma membrane transport [GO:0006893]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] GO:0000149; GO:0005484; GO:0005737; GO:0005886; GO:0006893; GO:0006906; GO:0007269; GO:0007274; GO:0016020; GO:0016081; GO:0016082; GO:0016192; GO:0019905; GO:0030054; GO:0031201; GO:0031629; GO:0043195; GO:0048172; GO:0048489 0 0 0 PF00835; P49013 CHOYP_LOC373212.1.1 m.42771 sp FBP3_STRPU 50 186 93 0 252 437 178 363 3.25E-54 203 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P63100 CHOYP_EF1G.1.3 m.12909 sp CANB1_RAT 90 170 17 0 1 170 1 170 3.25E-110 313 CANB1_RAT reviewed Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) Ppp3r1 Cna2 Cnb Rattus norvegicus (Rat) 170 protein dephosphorylation [GO:0006470] GO:0004721; GO:0005509; GO:0005829; GO:0006470; GO:0042383 0 0 0 PF13499; Q3KNM2 CHOYP_LOC100378338.1.1 m.57570 sp MARH5_MOUSE 64.286 266 94 1 10 275 12 276 3.25E-135 387 MARH5_MOUSE reviewed E3 ubiquitin-protein ligase MARCH5 (EC 6.3.2.-) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) 5-Mar Mus musculus (Mouse) 278 negative regulation of cell aging [GO:0090344]; positive regulation of mitochondrial fission [GO:0090141]; protein autoubiquitination [GO:0051865]; protein localization to mitochondrion [GO:0070585]; protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140] GO:0000209; GO:0004842; GO:0005741; GO:0005783; GO:0005789; GO:0008270; GO:0016020; GO:0016021; GO:0016874; GO:0051020; GO:0051865; GO:0070585; GO:0090140; GO:0090141; GO:0090344 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q4R562 CHOYP_ARRB.2.2 m.27006 sp ARRB1_MACFA 50.258 388 177 8 14 394 7 385 3.25E-120 358 ARRB1_MACFA reviewed Beta-arrestin-1 (Arrestin beta-1) ARRB1 QccE-17776 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 410 "negative regulation of signal transduction [GO:0009968]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0001934; GO:0002092; GO:0005634; GO:0005886; GO:0005905; GO:0006351; GO:0006355; GO:0007165; GO:0009968; GO:0015031; GO:0016023; GO:0031143 0 0 0 PF02752;PF00339; Q4V7N3 CHOYP_NEMVEDRAFT_V1G246990.1.1 m.16120 sp STYXA_XENLA 53.589 209 83 3 33 228 4 211 3.25E-76 233 STYXA_XENLA reviewed Serine/threonine/tyrosine-interacting protein A styx-a Xenopus laevis (African clawed frog) 223 0 GO:0008138 0 0 0 PF00782; Q6GM59 CHOYP_NEMVEDRAFT_V1G240018.1.1 m.54075 sp MOT12_XENLA 30.151 398 257 6 5 382 14 410 3.25E-41 157 MOT12_XENLA reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) 460 creatine transmembrane transport [GO:1902598] GO:0005308; GO:0005887; GO:0015293; GO:1902598 0 0 cd06174; PF07690; Q6P7W0 CHOYP_SENP6.1.1 m.12586 sp SENP6_MOUSE 35.784 408 227 12 1066 1446 417 816 3.25E-58 224 SENP6_MOUSE reviewed Sentrin-specific protease 6 (EC 3.4.22.68) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6) Senp6 Kiaa0797 Susp1 Mus musculus (Mouse) 1132 protein desumoylation [GO:0016926]; protein modification by small protein removal [GO:0070646]; protein sumoylation [GO:0016925]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169] GO:0005654; GO:0005737; GO:0016925; GO:0016926; GO:0016929; GO:0070646; GO:0090169; GO:0090234 PATHWAY: Protein modification; protein sumoylation. 0 0 PF02902; Q7L985 CHOYP_FLRT3.1.1 m.5249 sp LIGO2_HUMAN 26.111 360 177 9 42 321 42 392 3.25E-23 105 LIGO2_HUMAN reviewed Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (Leucine-rich repeat neuronal protein 3) (Leucine-rich repeat neuronal protein 6C) LINGO2 LERN3 LRRN6C UNQ9234/PRO31993 Homo sapiens (Human) 606 positive regulation of synapse assembly [GO:0051965] GO:0016021; GO:0051965 0 0 0 PF07679;PF13855; Q8C1F5 CHOYP_LOC100372826.1.1 m.29864 sp TTC16_MOUSE 38.793 464 277 3 205 662 14 476 3.25E-110 357 TTC16_MOUSE reviewed Tetratricopeptide repeat protein 16 (TPR repeat protein 16) Ttc16 Mus musculus (Mouse) 767 0 0 0 0 0 PF13181; Q8NG66 CHOYP_BRAFLDRAFT_121964.1.1 m.61283 sp NEK11_HUMAN 39.909 659 335 19 13 656 21 633 3.25E-146 442 NEK11_HUMAN reviewed Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) NEK11 Homo sapiens (Human) 645 G2 DNA damage checkpoint [GO:0031572]; histone phosphorylation [GO:0016572]; intracellular signal transduction [GO:0035556]; intra-S DNA damage checkpoint [GO:0031573]; mitotic cell cycle phase transition [GO:0044772]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle phase transition [GO:1901990] GO:0004674; GO:0005524; GO:0005654; GO:0005730; GO:0006468; GO:0016572; GO:0031572; GO:0031573; GO:0035556; GO:0044772; GO:0046872; GO:1901990 0 0 0 PF00069; Q8TDB6 CHOYP_WU_FI27D05.1.1 m.30351 sp DTX3L_HUMAN 32.308 130 80 3 289 410 608 737 3.25E-11 68.9 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q90YL3 CHOYP_LOC100879604.1.1 m.44302 sp MED26_DANRE 51.402 107 49 2 4 110 7 110 3.25E-25 114 MED26_DANRE reviewed Mediator of RNA polymerase II transcription subunit 26 (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) med26 crsp7 Danio rerio (Zebrafish) (Brachydanio rerio) 589 regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription initiation from RNA polymerase II promoter [GO:0006367] GO:0001104; GO:0003677; GO:0003713; GO:0006357; GO:0006367; GO:0016592 0 0 0 PF08711;PF15693;PF15694; Q9CQR7 CHOYP_LOC584085.1.1 m.13681 sp PEN2_MOUSE 59.406 101 41 0 15 115 1 101 3.25E-41 134 PEN2_MOUSE reviewed Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2) Psenen Pen2 Mus musculus (Mouse) 101 membrane protein ectodomain proteolysis [GO:0006509]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; protein processing [GO:0016485] GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0006509; GO:0007219; GO:0007220; GO:0016485; GO:0043085; GO:0070765 0 0 0 PF10251; Q9ESN6 CHOYP_LOC100368020.18.29 m.32791 sp TRIM2_MOUSE 26.549 226 140 11 55 271 523 731 3.25E-07 54.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NUQ9 CHOYP_FA49B.1.1 m.294 sp FA49B_HUMAN 62.08 327 120 2 1 327 1 323 3.25E-147 420 FA49B_HUMAN reviewed Protein FAM49B (L1) FAM49B BM-009 Homo sapiens (Human) 324 0 GO:0005929; GO:0016020; GO:0070062 0 0 0 PF07159; Q9PU36 CHOYP_PCLO.2.2 m.58947 sp PCLO_CHICK 52.201 159 57 2 152 291 4613 4771 3.25E-49 182 PCLO_CHICK reviewed Protein piccolo (Aczonin) (Fragment) PCLO ACZ Gallus gallus (Chicken) 5120 cytoskeleton organization [GO:0007010]; synapse assembly [GO:0007416] GO:0005509; GO:0005522; GO:0005544; GO:0007010; GO:0007416; GO:0030054; GO:0045202; GO:0048786 0 0 0 PF00168;PF05715; Q9R044 CHOYP_NPHN.1.1 m.26016 sp NPHN_RAT 23.633 512 314 20 128 589 553 1037 3.25E-17 90.1 NPHN_RAT reviewed Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Rattus norvegicus (Rat) 1252 cell adhesion [GO:0007155]; glomerular filtration [GO:0003094]; muscle organ development [GO:0007517] GO:0003094; GO:0005886; GO:0007155; GO:0007517; GO:0016020; GO:0016021; GO:0019904; GO:0030507; GO:0036057; GO:0043234; GO:0045121; GO:0051393 0 0 0 PF08205;PF00041; Q9UBC9 CHOYP_SPRR3.1.1 m.17722 sp SPRR3_HUMAN 35.088 114 74 0 3 116 39 152 3.25E-11 64.7 SPRR3_HUMAN reviewed Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin) SPRR3 SPRC Homo sapiens (Human) 169 epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; wound healing [GO:0042060] GO:0001533; GO:0005198; GO:0005737; GO:0008544; GO:0018149; GO:0030216; GO:0031424; GO:0042060; GO:0070062 0 0 0 0 Q9UGM3 CHOYP_DMBT1.27.34 m.53997 sp DMBT1_HUMAN 36.927 872 387 24 2 724 449 1306 3.25E-132 438 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UJW0 CHOYP_DCTN4.1.1 m.29541 sp DCTN4_HUMAN 50.109 459 214 8 1 447 1 456 3.25E-156 453 DCTN4_HUMAN reviewed Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) DCTN4 Homo sapiens (Human) 460 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; ER to Golgi vesicle-mediated transport [GO:0006888]; nuclear migration [GO:0007097] GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0005868; GO:0005869; GO:0006888; GO:0007097; GO:0019886; GO:0047485 0 0 0 PF05502; E1B9D8 CHOYP_LOC580601.3.5 m.46511 sp CBPC3_BOVIN 50.676 148 63 3 3 149 431 569 3.26E-41 163 CBPC3_BOVIN reviewed Cytosolic carboxypeptidase 3 (EC 3.4.17.-) (ATP/GTP-binding protein-like 3) AGBL3 CCP3 Bos taurus (Bovine) 1003 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005829; GO:0008270; GO:0035610 0 0 0 PF00246; O69060 CHOYP_BRAFLDRAFT_260946.1.2 m.54464 sp HTXA_PSEST 28.824 170 115 2 50 218 68 232 3.26E-13 70.9 HTXA_PSEST reviewed Probable alpha-ketoglutarate-dependent hypophosphite dioxygenase (EC 1.-.-.-) htxA Pseudomonas stutzeri (Pseudomonas perfectomarina) 286 0 GO:0051213 0 0 0 PF05721; P16157 CHOYP_TVAG_168010.20.45 m.40661 sp ANK1_HUMAN 35.857 251 160 1 1 251 294 543 3.26E-41 153 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P17141 CHOYP_ZFP37.4.4 m.58292 sp ZFP37_MOUSE 37.548 261 145 6 501 758 225 470 3.26E-43 169 ZFP37_MOUSE reviewed Zinc finger protein 37 (Zfp-37) (Male germ cell-specific zinc finger protein) Zfp37 Zfp-37 Mus musculus (Mouse) 594 "germ cell development [GO:0007281]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0007281; GO:0007283; GO:0008270 0 0 cd07765; PF01352;PF00096;PF13912; P23469 CHOYP_LOC100635116.5.5 m.53556 sp PTPRE_HUMAN 29.766 598 378 11 538 1107 115 698 3.26E-73 260 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P29314 CHOYP_LOC100558366.1.1 m.25761 sp RS9_RAT 87.379 103 7 1 1 97 92 194 3.26E-57 179 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P77851 CHOYP_LOC100892111.1.1 m.35230 sp HBD_THETC 28.571 182 110 4 2 172 3 175 3.26E-14 74.3 HBD_THETC reviewed 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157) (Beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) hbd Tthe_1657 Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814) (Clostridium thermosaccharolyticum) 281 butyrate metabolic process [GO:0019605] GO:0003857; GO:0008691; GO:0019605; GO:0070403 PATHWAY: Lipid metabolism; butanoate metabolism. 0 0 PF00725;PF02737; Q16982 CHOYP_NECX.1.1 m.56979 sp NECX_APLCA 88.889 189 21 0 1 189 1 189 3.26E-129 363 NECX_APLCA reviewed Neurocalcin 0 Aplysia californica (California sea hare) 193 0 GO:0005509 0 0 0 PF13499; Q18359 CHOYP_NDUA5.2.2 m.22155 sp NDUA5_CAEEL 45.455 110 60 0 8 117 40 149 3.26E-31 111 NDUA5_CAEEL reviewed Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 C33A12.1 Caenorhabditis elegans 150 respiratory electron transport chain [GO:0022904] GO:0005747; GO:0016651; GO:0022904 0 0 0 PF04716; Q24537 CHOYP_ISCW_ISCW017350.1.1 m.11950 sp HMG2_DROME 58.286 175 69 2 5 175 176 350 3.26E-67 213 HMG2_DROME reviewed High mobility group protein DSP1 (Protein dorsal switch 1) Dsp1 ssrp2 CG12223 Drosophila melanogaster (Fruit fly) 393 "chromatin remodeling [GO:0006338]; developmental process [GO:0032502]; DNA unwinding involved in DNA replication [GO:0006268]; leg disc development [GO:0035218]; negative regulation of antimicrobial humoral response [GO:0008348]; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0017055]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA binding [GO:0043388]; segment specification [GO:0007379]" GO:0000122; GO:0003677; GO:0003697; GO:0005634; GO:0005700; GO:0006268; GO:0006338; GO:0007379; GO:0008134; GO:0008301; GO:0008348; GO:0017025; GO:0017055; GO:0032502; GO:0035218; GO:0043388; GO:0045892 0 0 0 PF00505;PF09011; Q27433 CHOYP_MEC2.1.4 m.18899 sp MEC2_CAEEL 68.939 264 82 0 3 266 102 365 3.26E-126 370 MEC2_CAEEL reviewed Mechanosensory protein 2 mec-2 F14D12.4 Caenorhabditis elegans 481 mechanosensory behavior [GO:0007638]; response to mechanical stimulus [GO:0009612] GO:0007638; GO:0009612; GO:0015485; GO:0016021; GO:0032589; GO:0043005 0 0 0 PF01145; Q4R4V8 CHOYP_LOC100375693.2.2 m.23249 sp EI2BA_MACFA 54.321 162 73 1 12 173 1 161 3.26E-52 172 EI2BA_MACFA reviewed Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha) EIF2B1 QtrA-13377 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 305 cellular response to stimulus [GO:0051716]; oligodendrocyte development [GO:0014003]; positive regulation of GTPase activity [GO:0043547]; translational initiation [GO:0006413] GO:0003743; GO:0005737; GO:0005851; GO:0006413; GO:0014003; GO:0043547; GO:0051716 0 0 0 PF01008; Q54KA7 CHOYP_AFUA_1G01020.38.50 m.54480 sp SECG_DICDI 38.462 195 120 0 11 205 126 320 3.26E-32 125 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q69Z37 CHOYP_LOC100368251.5.6 m.59742 sp SAM9L_MOUSE 25.862 464 254 21 9 436 843 1252 3.26E-19 97.1 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6WKZ8 CHOYP_UBR2.1.2 m.50869 sp UBR2_MOUSE 33.636 110 63 4 1 106 1448 1551 3.26E-10 60.1 UBR2_MOUSE reviewed E3 ubiquitin-protein ligase UBR2 (EC 6.3.2.-) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II) Ubr2 Kiaa0349 Mus musculus (Mouse) 1755 cellular response to leucine [GO:0071233]; chromatin silencing [GO:0006342]; histone H2A ubiquitination [GO:0033522]; male meiosis I [GO:0007141]; negative regulation of TOR signaling [GO:0032007]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596] GO:0000151; GO:0004842; GO:0005654; GO:0005737; GO:0005886; GO:0006342; GO:0006511; GO:0007141; GO:0007283; GO:0008270; GO:0016874; GO:0032007; GO:0033522; GO:0061630; GO:0070728; GO:0071233; GO:0071596 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02617;PF02207; Q7T0W5 CHOYP_TFB1M.1.1 m.45868 sp TFB1M_XENLA 47.452 314 164 1 45 357 11 324 3.26E-104 313 TFB1M_XENLA reviewed "Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)" tfb1m Xenopus laevis (African clawed frog) 344 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000179; GO:0003677; GO:0003723; GO:0005739; GO:0006351; GO:0006355 0 0 0 PF00398; Q7TS68 CHOYP_BRAFLDRAFT_116066.1.1 m.31328 sp NSUN6_MOUSE 43.777 466 235 8 5 451 6 463 3.26E-121 364 NSUN6_MOUSE reviewed Putative methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 6) Nsun6 Mus musculus (Mouse) 476 RNA methylation [GO:0001510] GO:0001510; GO:0003723; GO:0008173; GO:0008757 0 0 0 PF01189; Q86FP7 CHOYP_RS23.3.9 m.22892 sp RS23_DERVA 87.413 143 17 1 15 156 1 143 3.26E-87 254 RS23_DERVA reviewed 40S ribosomal protein S23 RpS23 Dermacentor variabilis (American dog tick) 143 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935 0 0 cd03367; PF00164; Q8N2E2 CHOYP_VWDE.1.13 m.5351 sp VWDE_HUMAN 44.444 189 101 3 95 282 1297 1482 3.26E-42 172 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8Q0F9 CHOYP_BRAFLDRAFT_84838.5.6 m.57557 sp Y177_METMA 35 120 74 2 4 121 57 174 3.26E-11 61.6 Y177_METMA reviewed Macro domain-containing protein MM_0177 MM_0177 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 187 0 0 0 0 0 PF01661; Q8VCC1 CHOYP_LOC100372221.2.2 m.48004 sp PGDH_MOUSE 47.15 193 102 0 3 195 4 196 3.26E-58 187 PGDH_MOUSE reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) Hpgd Pgdh1 Mus musculus (Mouse) 269 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005654; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070062; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q92576 CHOYP_LOC100371354.1.1 m.47130 sp PHF3_HUMAN 40.652 460 218 9 1355 1790 925 1353 3.26E-90 332 PHF3_HUMAN reviewed PHD finger protein 3 PHF3 KIAA0244 Homo sapiens (Human) 2039 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0007275; GO:0008270 0 0 0 PF00628;PF07744;PF07500; Q99572 CHOYP_LOC100376482.2.7 m.9985 sp P2RX7_HUMAN 28.261 184 96 7 7 181 438 594 3.26E-09 58.5 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; Q99LJ2 CHOYP_BRAFLDRAFT_276832.1.2 m.7667 sp ABTB1_MOUSE 52.092 478 225 3 1 475 1 477 3.26E-178 511 ABTB1_MOUSE reviewed Ankyrin repeat and BTB/POZ domain-containing protein 1 Abtb1 Bpoz Mus musculus (Mouse) 478 0 GO:0003746; GO:0005730; GO:0005737; GO:0005886 0 0 0 PF12796;PF00651; Q9JIX0 CHOYP_LOC100374772.3.4 m.41361 sp ENY2_MOUSE 84.946 93 14 0 13 105 8 100 3.26E-55 169 ENY2_MOUSE reviewed Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) Eny2 Mus musculus (Mouse) 101 "histone deubiquitination [GO:0016578]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of transcription, DNA-templated [GO:0045893]; protein transport [GO:0015031]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]" GO:0000124; GO:0003682; GO:0003713; GO:0005643; GO:0006357; GO:0006368; GO:0015031; GO:0016578; GO:0016973; GO:0030374; GO:0045893; GO:0061179; GO:0070390; GO:0071819 0 0 0 0 Q9JKQ2 CHOYP_LOC100552593.1.3 m.7117 sp S26A5_MERUN 35.591 753 401 13 17 716 10 731 3.26E-150 458 S26A5_MERUN reviewed Prestin (Solute carrier family 26 member 5) SLC26A5 PRES Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) 744 regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605] GO:0007605; GO:0008271; GO:0008360; GO:0016021; GO:0016323 0 0 0 PF01740;PF00916; Q9VAI0 CHOYP_ISCW_ISCW009614.2.2 m.53688 sp GNA1_DROME 38.655 119 71 2 165 283 40 156 3.26E-20 90.1 GNA1_DROME reviewed Probable glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) CG1969 Drosophila melanogaster (Fruit fly) 219 UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0004343; GO:0006048 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. 0 0 PF00583; Q9VCA8 CHOYP_LOC100641396.20.27 m.58076 sp ANKHM_DROME 32.544 507 303 19 40 513 552 1052 3.26E-44 171 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9ZQ47 CHOYP_LOC100367312.4.13 m.10288 sp GRDP1_ARATH 41 300 155 6 3 281 13 311 3.26E-58 216 GRDP1_ARATH reviewed Glycine-rich domain-containing protein 1 (AtGRDP1) GRDP1 At2g22660 T9I22.10 Arabidopsis thaliana (Mouse-ear cress) 819 abscisic acid-activated signaling pathway [GO:0009738]; cellular response to osmotic stress [GO:0071470]; regulation of abscisic acid-activated signaling pathway [GO:0009787]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650] GO:0005198; GO:0005886; GO:0006979; GO:0009650; GO:0009738; GO:0009787; GO:0071470 0 0 0 PF07173; A5PN52 CHOYP_BRAFLDRAFT_93856.4.6 m.32826 sp CK088_DANRE 45.763 118 59 2 1 118 29 141 3.27E-21 87.4 CK088_DANRE reviewed UPF0722 protein C11orf88 homolog si:dkey-27p23.3 Danio rerio (Zebrafish) (Brachydanio rerio) 164 skeletal muscle fiber development [GO:0048741] GO:0048741 0 0 0 0 A8WQK3 CHOYP_LOC100374210.1.2 m.16994 sp ACH1_CAEBR 31.211 487 284 9 15 457 12 491 3.27E-76 250 ACH1_CAEBR reviewed Acetylcholine receptor subunit alpha-type acr-16 acr-16 CBG01491 Caenorhabditis briggsae 499 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; D2GXS7 CHOYP_NEMVEDRAFT_V1G160199.2.2 m.48249 sp TRIM2_AILME 29.825 114 75 3 225 333 631 744 3.27E-07 55.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O42281 CHOYP_PRPH2.1.1 m.49508 sp PRPH2_CHICK 26.733 303 199 9 11 295 1 298 3.27E-38 144 PRPH2_CHICK reviewed Peripherin-2 (CRDS1) (Photoreceptor outer segment membrane glycoprotein 1) (Retinal degeneration slow protein) PRPH2 RDS Gallus gallus (Chicken) 354 cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] GO:0001750; GO:0005887; GO:0007155; GO:0007166; GO:0007601; GO:0060041 0 0 0 PF00335; O60347 CHOYP_LOC100566968.1.1 m.15269 sp TBC12_HUMAN 35.047 214 113 4 318 505 265 478 3.27E-33 137 TBC12_HUMAN reviewed TBC1 domain family member 12 TBC1D12 KIAA0608 Homo sapiens (Human) 775 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of autophagosome assembly [GO:2000785]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005776; GO:0006886; GO:0017137; GO:0031338; GO:0055037; GO:0090630; GO:2000785 0 0 0 PF00566; O70277 CHOYP_BRAFLDRAFT_255103.13.18 m.52741 sp TRIM3_RAT 27.407 135 87 4 79 207 614 743 3.27E-09 60.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_TRI45.6.23 m.20673 sp TRIM3_RAT 25.185 135 100 1 59 193 115 248 3.27E-07 53.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_LOC100182840.4.4 m.45613 sp MEGF6_HUMAN 38.043 276 151 13 174 448 817 1073 3.27E-33 136 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75382 CHOYP_BRAFLDRAFT_69766.1.1 m.35537 sp TRIM3_HUMAN 29.268 123 86 1 33 155 622 743 3.27E-08 59.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P00428 CHOYP_COX5B.3.3 m.38557 sp COX5B_BOVIN 44.565 92 46 3 84 174 35 122 3.27E-18 79.7 COX5B_BOVIN reviewed "Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide VIa) (Cytochrome c oxidase polypeptide Vb)" COX5B Bos taurus (Bovine) 129 0 GO:0004129; GO:0005743; GO:0045277; GO:0046872 0 0 cd00924; PF01215; P0DKQ7 CHOYP_CXL.1.1 m.33397 sp CXL_CONCN 48.026 152 62 9 24 164 1 146 3.27E-29 107 CXL_CONCN reviewed Linear conopeptide [Cleaved into: Linear conopeptide-Cn1; Linear conopeptide-Cn2 ([oxMet6]-Cn2); Linear conopeptide-Cn3; Linear conopeptide-Cn4] 0 Conus consors (Singed cone) 146 0 GO:0005576 0 0 0 0 P10394 CHOYP_LOC100636756.1.4 m.4102 sp POL4_DROME 29.658 263 178 5 1 261 979 1236 3.27E-28 119 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P20825 CHOYP_contig_030266 m.34427 sp POL2_DROME 34.88 668 390 15 42 681 162 812 3.27E-110 362 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P22695 CHOYP_QCR2.1.1 m.35612 sp QCR2_HUMAN 30.258 466 269 10 29 487 37 453 3.27E-52 186 QCR2_HUMAN reviewed "Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2)" UQCRC2 Homo sapiens (Human) 453 "aerobic respiration [GO:0009060]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidative phosphorylation [GO:0006119]; protein processing [GO:0016485]" GO:0004222; GO:0005654; GO:0005739; GO:0005743; GO:0005750; GO:0006119; GO:0006122; GO:0008270; GO:0009060; GO:0016485; GO:0043209; GO:0070062 0 0 0 PF00675;PF05193; P35244 CHOYP_LOC100358262.2.3 m.28381 sp RFA3_HUMAN 40.678 118 69 1 1 118 4 120 3.27E-27 100 RFA3_HUMAN reviewed Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) RPA3 REPA3 RPA14 Homo sapiens (Human) 121 "base-excision repair [GO:0006284]; DNA damage response, detection of DNA damage [GO:0042769]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; interstrand cross-link repair [GO:0036297]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; regulation of cell proliferation [GO:0042127]; regulation of cellular response to heat [GO:1900034]; regulation of mitotic cell cycle [GO:0007346]; regulation of signal transduction by p53 class mediator [GO:1901796]; telomere maintenance via recombination [GO:0000722]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]" GO:0000082; GO:0000722; GO:0000724; GO:0003684; GO:0003697; GO:0005654; GO:0005662; GO:0006260; GO:0006283; GO:0006284; GO:0006289; GO:0006293; GO:0006294; GO:0006295; GO:0006296; GO:0006297; GO:0006298; GO:0007346; GO:0019985; GO:0033683; GO:0036297; GO:0042127; GO:0042276; GO:0042769; GO:0070987; GO:1900034; GO:1901796 0 0 0 PF08661; P41116 CHOYP_RL8.5.10 m.35160 sp RL8_XENLA 81.618 136 25 0 2 137 121 256 3.27E-76 229 RL8_XENLA reviewed 60S ribosomal protein L8 rpl8 Xenopus laevis (African clawed frog) 257 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934; GO:0019843 0 0 0 PF00181;PF03947; P82596 CHOYP_LOC576927.1.4 m.1819 sp PLC_HALLA 27.972 143 85 5 54 193 2 129 3.27E-11 62 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; P97500 CHOYP_MYT1.2.2 m.49915 sp MYT1L_MOUSE 44.697 264 114 6 442 682 905 1159 3.27E-59 220 MYT1L_MOUSE reviewed Myelin transcription factor 1-like protein (MyT1-L) (MyT1L) (Neural zinc finger factor 1) (NZF-1) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) Myt1l Kiaa1106 Nzf1 Png1 Mus musculus (Mouse) 1187 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007399; GO:0008270; GO:0030154 0 0 0 PF08474;PF01530; Q03172 CHOYP_DGRI_GH21290.1.1 m.52483 sp ZEP1_MOUSE 47.273 220 103 5 566 774 1918 2135 3.27E-48 194 ZEP1_MOUSE reviewed Zinc finger protein 40 (Alpha A-crystallin-binding protein 1) (Alpha A-CRYBP1) (Alpha A-crystallin-binding protein I) (Transcription factor alphaA-CRYBP1) Hivep1 Cryabp1 Znf40 Mus musculus (Mouse) 2688 "multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003676; GO:0003677; GO:0005634; GO:0005739; GO:0006351; GO:0007165; GO:0007275; GO:0008270; GO:0045892; GO:0071837 0 0 0 0 Q08BB2 CHOYP_LOC579513.1.1 m.61078 sp P2012_DANRE 46.108 501 263 3 11 505 23 522 3.27E-162 473 P2012_DANRE reviewed Probable carboxypeptidase PM20D1.2 (EC 3.4.17.-) (Peptidase M20 domain-containing protein 1.2) pm20d1.2 zgc:154035 Danio rerio (Zebrafish) (Brachydanio rerio) 522 peptide catabolic process [GO:0043171] GO:0005576; GO:0008270; GO:0043171; GO:0070573 0 0 0 PF07687;PF01546; Q0VGY8 CHOYP_AOR_1_1386094.6.6 m.42721 sp TANC1_MOUSE 40.517 116 69 0 1 116 1093 1208 3.27E-21 90.5 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q14162 CHOYP_MEGF10.5.12 m.32917 sp SREC_HUMAN 33.835 133 68 6 183 302 213 338 3.27E-10 65.9 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q29611 CHOYP_LOC100371489.1.2 m.24333 sp CLN3_CANLF 46.667 240 126 2 6 243 35 274 3.27E-61 201 CLN3_CANLF reviewed Battenin (Protein CLN3) CLN3 Canis lupus familiaris (Dog) (Canis familiaris) 438 amyloid precursor protein catabolic process [GO:0042987]; arginine transport [GO:0015809]; ceramide metabolic process [GO:0006672]; galactosylceramide metabolic process [GO:0006681]; globoside metabolic process [GO:0001575]; glucosylceramide metabolic process [GO:0006678]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; negative regulation of apoptotic process [GO:0043066]; receptor-mediated endocytosis [GO:0006898]; sphingomyelin metabolic process [GO:0006684]; vacuolar transport [GO:0007034]; vesicle transport along microtubule [GO:0047496] GO:0000139; GO:0001575; GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005783; GO:0005794; GO:0005795; GO:0005802; GO:0005886; GO:0005901; GO:0006672; GO:0006678; GO:0006681; GO:0006684; GO:0006898; GO:0007034; GO:0007042; GO:0008021; GO:0015809; GO:0016021; GO:0030176; GO:0031301; GO:0035752; GO:0042987; GO:0043005; GO:0043066; GO:0045121; GO:0047496 0 0 0 PF02487; Q494V2 CHOYP_LOC100370537.1.1 m.10588 sp CP100_HUMAN 42.321 560 289 8 54 579 51 610 3.27E-139 420 CP100_HUMAN reviewed Cilia- and flagella-associated protein 100 (Coiled-coil domain-containing protein 37) CFAP100 CCDC37 Homo sapiens (Human) 611 0 GO:0031514 0 0 0 PF13863; Q5ZLS8 CHOYP_BRAFLDRAFT_203057.1.1 m.47437 sp INT10_CHICK 36.119 706 392 15 10 667 3 697 3.27E-145 442 INT10_CHICK reviewed Integrator complex subunit 10 (Int10) INTS10 RCJMB04_4p16 Gallus gallus (Chicken) 710 snRNA processing [GO:0016180] GO:0016180; GO:0032039 0 0 0 0 Q641F1 CHOYP_UBCP1.1.1 m.7721 sp UBCP1_XENLA 67.937 315 99 2 9 321 4 318 3.27E-150 427 UBCP1_XENLA reviewed Ubiquitin-like domain-containing CTD phosphatase 1 (EC 3.1.3.16) (Nuclear proteasome inhibitor UBLCP1) ublcp1 Xenopus laevis (African clawed frog) 318 0 GO:0004721; GO:0005634 0 0 0 PF03031;PF00240; Q6NZF1 CHOYP_ZC11A.1.1 m.60722 sp ZC11A_MOUSE 52.874 87 38 1 5 91 5 88 3.27E-28 125 ZC11A_MOUSE reviewed Zinc finger CCCH domain-containing protein 11A Zc3h11a Kiaa0663 Mus musculus (Mouse) 792 poly(A)+ mRNA export from nucleus [GO:0016973] GO:0000346; GO:0016973; GO:0044822; GO:0046872 0 0 0 0 Q75J93 CHOYP_LOC100638372.1.1 m.60468 sp CPAS1_DICDI 29.02 541 308 12 140 660 280 764 3.27E-58 216 CPAS1_DICDI reviewed Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) 842 ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0006886; GO:0006888; GO:0007264; GO:0008270; GO:0030127 0 0 0 PF00071; Q7JWG9 CHOYP_RM52.1.1 m.40897 sp RM52_DROME 42.683 82 47 0 45 126 27 108 3.27E-19 80.9 RM52_DROME reviewed "39S ribosomal protein L52, mitochondrial (L52mt) (MRP-L52)" mRpL52 CG1577 Drosophila melanogaster (Fruit fly) 126 translation [GO:0006412] GO:0003735; GO:0005762; GO:0006412 0 0 0 0 Q80VI1 CHOYP_LOC100369333.31.32 m.60382 sp TRI56_MOUSE 24.615 260 156 10 84 314 114 362 3.27E-09 63.5 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q93XW5 CHOYP_LOC100808508.1.1 m.59055 sp NSP5_ARATH 36.196 326 195 8 5 324 4 322 3.27E-63 206 NSP5_ARATH reviewed Nitrile-specifier protein 5 (AtNSP5) NSP5 At5g48180 MIF21.7 Arabidopsis thaliana (Mouse-ear cress) 326 glucosinolate catabolic process [GO:0019762]; nitrile biosynthetic process [GO:0080028] GO:0005829; GO:0019762; GO:0080028 0 0 0 PF01344; Q94BY6 CHOYP_NEMVEDRAFT_V1G201445.5.5 m.56280 sp ATL75_ARATH 34.409 93 58 2 234 325 119 209 3.27E-09 61.2 ATL75_ARATH reviewed RING-H2 finger protein ATL75 ATL75 At1g49200 F27J15.33 Arabidopsis thaliana (Mouse-ear cress) 226 protein ubiquitination [GO:0016567] GO:0008270; GO:0016021; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q99836 CHOYP_MYD88.5.7 m.41603 sp MYD88_HUMAN 42.808 292 151 6 25 315 20 296 3.27E-69 225 MYD88_HUMAN reviewed Myeloid differentiation primary response protein MyD88 MYD88 Homo sapiens (Human) 296 3'-UTR-mediated mRNA stabilization [GO:0070935]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of type I interferon production [GO:0032481]; regulation of inflammatory response [GO:0050727]; response to interleukin-1 [GO:0070555]; signal transduction [GO:0007165]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0002755; GO:0005123; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006915; GO:0006954; GO:0007165; GO:0007166; GO:0010008; GO:0032481; GO:0032740; GO:0032747; GO:0032755; GO:0034162; GO:0042802; GO:0043066; GO:0043123; GO:0043621; GO:0045087; GO:0050727; GO:0050830; GO:0051092; GO:0070555; GO:0070935; GO:0070976; GO:0071260 0 0 0 PF00531;PF01582; Q9QXV1 CHOYP_ISCW_ISCW012843.1.1 m.37381 sp CBX8_MOUSE 66.234 77 24 1 40 114 1 77 3.27E-24 106 CBX8_MOUSE reviewed Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (mPc3) Cbx8 Pc3 Mus musculus (Mouse) 362 "cellular response to hydrogen peroxide [GO:0070301]; chromatin silencing [GO:0006342]; histone ubiquitination [GO:0016574]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of cell proliferation [GO:0008284]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA repair [GO:0045739]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000151; GO:0000790; GO:0000792; GO:0003727; GO:0005634; GO:0005654; GO:0006342; GO:0006351; GO:0008284; GO:0016574; GO:0031519; GO:0032967; GO:0035064; GO:0035102; GO:0045739; GO:0070301; GO:0097027 0 0 0 PF00385; Q9UDV7 CHOYP_ZEB2.1.1 m.29733 sp ZN282_HUMAN 39.326 89 40 2 347 435 575 649 3.27E-11 70.5 ZN282_HUMAN reviewed Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) ZNF282 HUB1 Homo sapiens (Human) 671 "negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0045892 0 0 cd07765; PF12417;PF01352;PF00096;PF13912; A2VD82 CHOYP_NEMVEDRAFT_V1G157950.1.1 m.4584 sp TTC38_XENLA 39.13 460 279 1 7 466 8 466 3.28E-123 370 TTC38_XENLA reviewed Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 Xenopus laevis (African clawed frog) 469 0 0 0 0 0 0 A3KMZ6 CHOYP_COX11.1.1 m.17680 sp COX11_BOVIN 59.5 200 73 5 114 306 75 273 3.28E-76 237 COX11_BOVIN reviewed "Cytochrome c oxidase assembly protein COX11, mitochondrial" COX11 Bos taurus (Bovine) 282 aerobic respiration [GO:0009060]; respiratory chain complex IV assembly [GO:0008535] GO:0005507; GO:0005739; GO:0005743; GO:0008535; GO:0009060; GO:0016021 0 0 0 PF04442; A4IF63 CHOYP_TRI42.1.1 m.62274 sp TRIM2_BOVIN 28.141 199 138 3 406 602 536 731 3.28E-14 79.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_CARNS1.4.6 m.40250 sp CRNS1_HUMAN 39.13 115 56 5 1 111 694 798 3.28E-12 65.5 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 B3EWZ5 CHOYP_NEMVEDRAFT_V1G198667.6.15 m.17080 sp MLRP1_ACRMI 31.053 1140 616 39 2 1058 757 1809 3.28E-126 429 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O17320 CHOYP_ACT.18.27 m.45538 sp ACT_CRAGI 92.611 203 15 0 1 203 1 203 3.28E-139 397 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O35309 CHOYP_BRAFLDRAFT_74879.5.6 m.53030 sp NMI_MOUSE 27.477 222 134 11 428 631 97 309 3.28E-06 53.1 NMI_MOUSE reviewed N-myc-interactor (Nmi) (N-myc and STAT interactor) Nmi Mus musculus (Mouse) 314 interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha biosynthetic process [GO:0045355]; negative regulation of interferon-beta biosynthetic process [GO:0045358]; negative regulation of type I interferon production [GO:0032480]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003712; GO:0005654; GO:0005737; GO:0006366; GO:0032480; GO:0045355; GO:0045358; GO:0045824; GO:0060333; GO:1902524 0 0 0 PF07334;PF07292; O57592 CHOYP_RL7A.1.6 m.4608 sp RL7A_TAKRU 75.904 166 40 0 3 168 101 266 3.28E-90 266 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O60290 CHOYP_LOC100891334.1.2 m.24992 sp ZN862_HUMAN 28.022 182 115 4 1 178 485 654 3.28E-17 82 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; O73853 CHOYP_LOC100557193.1.1 m.44862 sp CP17A_ICTPU 29.038 520 324 12 2 497 1 499 3.28E-62 214 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; P10394 CHOYP_LOC579970.3.5 m.19960 sp POL4_DROME 28.175 756 464 19 2 713 515 1235 3.28E-79 280 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P17248 CHOYP_SYWC.1.5 m.20735 sp SYWC_BOVIN 71.22 205 58 1 9 213 75 278 3.28E-104 311 SYWC_BOVIN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS Bos taurus (Bovine) 476 regulation of angiogenesis [GO:0045765]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0006436; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P17789 CHOYP_LOC100729612.1.1 m.64101 sp TTKB_DROME 34.524 84 49 3 184 264 482 562 3.28E-09 60.8 TTKB_DROME reviewed "Protein tramtrack, beta isoform (Repressor protein fushi tarazu) (Tramtrack p69)" ttk FTZ-F2 CG1856 Drosophila melanogaster (Fruit fly) 643 "border follicle cell migration [GO:0007298]; brain morphogenesis [GO:0048854]; branch fusion, open tracheal system [GO:0035147]; branching involved in open tracheal system development [GO:0060446]; cell fate determination [GO:0001709]; chitin-based cuticle development [GO:0040003]; compound eye cone cell differentiation [GO:0042675]; compound eye corneal lens morphogenesis [GO:0048750]; dendrite morphogenesis [GO:0048813]; dorsal appendage formation [GO:0046843]; dorsal trunk growth, open tracheal system [GO:0035001]; imaginal disc-derived wing morphogenesis [GO:0007476]; inter-male aggressive behavior [GO:0002121]; locomotion involved in locomotory behavior [GO:0031987]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron development [GO:0048666]; ovarian follicle cell development [GO:0030707]; peripheral nervous system development [GO:0007422]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 development [GO:0048053]; R7 cell development [GO:0045467]; regulation of cell shape [GO:0008360]; regulation of compound eye cone cell fate specification [GO:0042682]; regulation of embryonic cell shape [GO:0016476]; regulation of tube size, open tracheal system [GO:0035151]; startle response [GO:0001964]; tracheal outgrowth, open tracheal system [GO:0007426]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0000980; GO:0001078; GO:0001709; GO:0001964; GO:0002121; GO:0003677; GO:0003682; GO:0005634; GO:0005700; GO:0006351; GO:0007298; GO:0007422; GO:0007426; GO:0007476; GO:0008360; GO:0016476; GO:0017053; GO:0030707; GO:0031208; GO:0031987; GO:0035001; GO:0035147; GO:0035151; GO:0040003; GO:0042675; GO:0042682; GO:0042803; GO:0043388; GO:0045467; GO:0045892; GO:0045944; GO:0046843; GO:0046872; GO:0048053; GO:0048666; GO:0048750; GO:0048813; GO:0048854; GO:0060446 0 0 0 PF00651; P27634 CHOYP_EEF1A.3.3 m.37431 sp EF1A_RHYAM 91.089 101 9 0 40 140 3 103 3.28E-61 196 EF1A_RHYAM reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Rhynchosciara americana (Fungus gnat) 412 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; P28699 CHOYP_RORA.1.2 m.59037 sp RARG_XENLA 29.016 386 217 7 126 511 109 437 3.28E-41 157 RARG_XENLA reviewed Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) rarg nr1b3 Xenopus laevis (African clawed frog) 476 "transcription, DNA-templated [GO:0006351]" GO:0003707; GO:0003708; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; P45878 CHOYP_LOC659512.2.4 m.10747 sp FKBP2_MOUSE 41.053 95 55 1 41 134 40 134 3.28E-18 80.9 FKBP2_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase) Fkbp2 Fkbp13 Mus musculus (Mouse) 140 chaperone-mediated protein folding [GO:0061077] GO:0003755; GO:0005528; GO:0005789; GO:0061077; GO:0070062 0 0 0 PF00254; P49354 CHOYP_FNTA.1.1 m.40996 sp FNTA_HUMAN 60.759 316 122 2 80 394 62 376 3.28E-139 404 FNTA_HUMAN reviewed Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) FNTA Homo sapiens (Human) 379 cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; neurotransmitter receptor metabolic process [GO:0045213]; positive regulation of deacetylase activity [GO:0090045]; positive regulation of tubulin deacetylation [GO:0090044]; protein farnesylation [GO:0018343]; protein geranylgeranylation [GO:0018344]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0004660; GO:0004661; GO:0004662; GO:0004663; GO:0005737; GO:0005829; GO:0005875; GO:0005886; GO:0005953; GO:0005965; GO:0006921; GO:0007179; GO:0008017; GO:0018343; GO:0018344; GO:0022400; GO:0030548; GO:0043014; GO:0045213; GO:0071340; GO:0090044; GO:0090045 0 0 0 PF01239; P55210 CHOYP_LOC100331324.3.3 m.66511 sp CASP7_HUMAN 31.128 257 133 10 12 246 67 301 3.28E-22 96.3 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P59759 CHOYP_MKL2.1.1 m.25855 sp MKL2_MOUSE 39.871 311 136 14 96 390 26 301 3.28E-39 163 MKL2_MOUSE reviewed MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) Mkl2 Mrtfb Mus musculus (Mouse) 1080 "actin cytoskeleton organization [GO:0030036]; blood vessel morphogenesis [GO:0048514]; cardiac muscle tissue development [GO:0048738]; embryonic organ development [GO:0048568]; forebrain development [GO:0030900]; gene expression [GO:0010467]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; muscle organ development [GO:0007517]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; positive regulation of striated muscle tissue development [GO:0045844]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of gene expression [GO:0010468]; smooth muscle cell differentiation [GO:0051145]" GO:0001105; GO:0001701; GO:0001764; GO:0001889; GO:0003007; GO:0003700; GO:0003713; GO:0003779; GO:0005634; GO:0005737; GO:0007507; GO:0007517; GO:0010467; GO:0010468; GO:0030036; GO:0030900; GO:0031175; GO:0045844; GO:0045893; GO:0045944; GO:0048514; GO:0048568; GO:0048738; GO:0051145 0 0 0 PF02755;PF02037; Q06852 CHOYP_NAEGRDRAFT_68488.1.1 m.3170 sp SLAP1_CLOTH 51.872 561 142 45 1 479 1384 1898 3.28E-27 122 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q14517 CHOYP_BRAFLDRAFT_64071.23.35 m.34128 sp FAT1_HUMAN 33.846 130 58 5 6081 6196 4095 4210 3.28E-10 71.6 FAT1_HUMAN reviewed "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; single organismal cell-cell adhesion [GO:0016337] GO:0005509; GO:0005634; GO:0005886; GO:0005887; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016337; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q16563 CHOYP_SYPL1.1.1 m.49654 sp SYPL1_HUMAN 39.841 251 138 5 12 256 11 254 3.28E-50 168 SYPL1_HUMAN reviewed Synaptophysin-like protein 1 (Pantophysin) SYPL1 SYPL Homo sapiens (Human) 259 chemical synaptic transmission [GO:0007268] GO:0005215; GO:0005887; GO:0007268; GO:0016021; GO:0030141; GO:0030285; GO:0042470; GO:0070062 0 0 0 PF01284; Q54KF7 CHOYP_contig_013922 m.15829 sp SIBA_DICDI 23.443 273 173 11 4 267 1 246 3.28E-07 58.9 SIBA_DICDI reviewed Integrin beta-like protein A (109 gene 1 protein) sibA DDB_G0287363 Dictyostelium discoideum (Slime mold) 1927 cell-substrate adhesion [GO:0031589]; phagocytosis [GO:0006909] GO:0005509; GO:0005769; GO:0005886; GO:0006909; GO:0009986; GO:0016021; GO:0031589; GO:0055037 0 0 0 0 Q5UQP2 CHOYP_BRAFLDRAFT_118620.1.3 m.24957 sp YL446_MIMIV 29.381 194 125 4 81 272 55 238 3.28E-17 86.7 YL446_MIMIV reviewed Uncharacterized protein L446 (EC 3.1.1.-) MIMI_L446 Acanthamoeba polyphaga mimivirus (APMV) 332 lipid catabolic process [GO:0016042] GO:0016021; GO:0016042; GO:0016787 0 0 0 PF01734; Q5ZHW4 CHOYP_DANA_GF15280.2.2 m.23371 sp RAB5B_CHICK 50.754 199 84 4 4 202 6 190 3.28E-64 201 RAB5B_CHICK reviewed Ras-related protein Rab-5B RAB5B RCJMB04_32j11 Gallus gallus (Chicken) 215 protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005769; GO:0005886; GO:0007264; GO:0015031; GO:0019003; GO:0030100; GO:0030139; GO:0031901 0 0 0 PF00071; Q62384 CHOYP_ZNF259.1.1 m.10424 sp ZPR1_MOUSE 52.928 444 187 4 11 452 30 453 3.28E-168 484 ZPR1_MOUSE reviewed Zinc finger protein ZPR1 (Zinc finger protein 259) Zpr1 Zfp259 Znf259 Mus musculus (Mouse) 459 apoptotic process involved in development [GO:1902742]; axon development [GO:0061564]; Cajal body organization [GO:0030576]; cellular response to epidermal growth factor stimulus [GO:0071364]; DNA endoreduplication [GO:0042023]; inner cell mass cell proliferation [GO:0001833]; microtubule cytoskeleton organization [GO:0000226]; mRNA processing [GO:0006397]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]; positive regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071931]; pre-mRNA catabolic process [GO:1990261]; regulation of myelination [GO:0031641]; RNA splicing [GO:0008380]; spinal cord development [GO:0021510]; trophectodermal cell proliferation [GO:0001834] GO:0000226; GO:0001833; GO:0001834; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006397; GO:0008270; GO:0008380; GO:0010628; GO:0015030; GO:0021510; GO:0030424; GO:0030426; GO:0030576; GO:0030971; GO:0031369; GO:0031641; GO:0032797; GO:0033120; GO:0042023; GO:0042307; GO:0043025; GO:0043204; GO:0045927; GO:0048471; GO:0061564; GO:0071364; GO:0071931; GO:0097504; GO:1902742; GO:1990261; GO:2000672 0 0 0 PF03367; Q640R7 CHOYP_RAS3.1.1 m.15706 sp RAP1B_XENTR 84.409 186 26 2 1 185 1 184 3.28E-110 315 RAP1B_XENTR reviewed Ras-related protein Rap-1b rap1b TTpA008e07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 184 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005829; GO:0005886; GO:0007264; GO:0030054 0 0 0 PF00071; Q6NZJ6 CHOYP_EIF4G1.1.2 m.33170 sp IF4G1_MOUSE 37.465 1073 537 30 422 1389 382 1425 3.28E-165 550 IF4G1_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) Eif4g1 Mus musculus (Mouse) 1600 behavioral fear response [GO:0001662]; positive regulation of neuron differentiation [GO:0045666]; regulation of translational initiation [GO:0006446] GO:0001662; GO:0003743; GO:0005737; GO:0006446; GO:0008190; GO:0016020; GO:0044822; GO:0045666 0 0 0 PF02847;PF02854;PF02020; Q6PFY8 CHOYP_LOC591441.1.1 m.19965 sp TRI45_MOUSE 22.822 241 176 4 34 273 135 366 3.28E-13 75.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8BFY6 CHOYP_LOC100370201.1.1 m.974 sp PEF1_MOUSE 46.842 190 95 3 110 293 86 275 3.28E-53 177 PEF1_MOUSE reviewed Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) Pef1 Mus musculus (Mouse) 275 proteolysis [GO:0006508]; response to calcium ion [GO:0051592] GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0016020; GO:0044822; GO:0046982; GO:0046983; GO:0051592; GO:0070062 0 0 0 PF13405;PF13499; Q9CX34 CHOYP_LOC100210536.1.1 m.18414 sp SGT1_MOUSE 41.096 365 176 4 24 388 11 336 3.28E-85 265 SGT1_MOUSE reviewed Protein SGT1 homolog (Suppressor of G2 allele of SKP1 homolog) Sugt1 Mus musculus (Mouse) 336 positive regulation by host of symbiont catalytic activity [GO:0043947]; regulation of protein stability [GO:0031647] GO:0005634; GO:0005737; GO:0031647; GO:0043234; GO:0043947 0 0 0 PF04969;PF05002;PF13181; Q9H8W5 CHOYP_LOC100066246.1.1 m.34325 sp TRI45_HUMAN 25.641 195 117 9 26 196 129 319 3.28E-07 54.7 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9MBF8 CHOYP_LOC100376274.2.7 m.20968 sp DYH1B_CHLRE 25.253 693 449 13 1007 1683 2818 3457 3.28E-59 232 DYH1B_CHLRE reviewed "Dynein-1-beta heavy chain, flagellar inner arm I1 complex (1-beta DHC) (Dynein-1, subspecies f)" DHC10 IDA2 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4513 cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005930; GO:0008017; GO:0016887; GO:0031514; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q9NQC3 CHOYP_LOC655520.1.2 m.497 sp RTN4_HUMAN 54.545 187 85 0 187 373 1004 1190 3.28E-70 241 RTN4_HUMAN reviewed Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) 1192 apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; cardiac epithelial to mesenchymal transition [GO:0060317]; cerebral cortex radial glia guided migration [GO:0021801]; endoplasmic reticulum tubular network assembly [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of axon extension [GO:0030517]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell growth [GO:0030308]; nuclear pore complex assembly [GO:0051292]; regulation of apoptotic process [GO:0042981]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of cell migration [GO:0030334] GO:0005622; GO:0005635; GO:0005783; GO:0005789; GO:0005886; GO:0005913; GO:0006915; GO:0007413; GO:0021801; GO:0030176; GO:0030308; GO:0030334; GO:0030517; GO:0042981; GO:0042995; GO:0044822; GO:0050771; GO:0051292; GO:0060317; GO:0070062; GO:0071786; GO:0071787; GO:0098641; GO:2000172 0 0 0 PF02453; Q9VCA8 CHOYP_LOC583072.10.25 m.42234 sp ANKHM_DROME 30.316 475 259 17 160 626 550 960 3.28E-36 149 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; D3ZY60 CHOYP_LOC100370358.1.1 m.39703 sp PKHA8_RAT 44.914 521 271 6 1 506 1 520 3.29E-144 427 PKHA8_RAT reviewed Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) Plekha8 Fapp2 Rattus norvegicus (Rat) 520 ER to Golgi ceramide transport [GO:0035621]; lipid transport [GO:0006869]; protein transport [GO:0015031] GO:0005802; GO:0006869; GO:0015031; GO:0016020; GO:0017089; GO:0035621; GO:0051861; GO:0070273; GO:0097001 0 0 0 PF08718;PF00169; F1MBP6 CHOYP_LOC100368146.1.1 m.57661 sp KLHL3_BOVIN 35.902 571 344 7 5 564 24 583 3.29E-118 364 KLHL3_BOVIN reviewed Kelch-like protein 3 KLHL3 Bos taurus (Bovine) 587 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O16025 CHOYP_LOC584481.3.10 m.27859 sp AOSL_PLEHO 27.745 501 286 17 131 585 596 1066 3.29E-44 172 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O46385 CHOYP_SVIL.1.1 m.1140 sp SVIL_BOVIN 46.512 258 128 6 5 258 1611 1862 3.29E-72 243 SVIL_BOVIN reviewed Supervillin (Archvillin) (p205/p250) SVIL Bos taurus (Bovine) 2194 cytoskeleton organization [GO:0007010]; positive regulation of cytokinesis [GO:0032467] GO:0002102; GO:0005737; GO:0005886; GO:0007010; GO:0030054; GO:0030496; GO:0032154; GO:0032467; GO:0036449; GO:0071437 0 0 0 PF00626;PF02209; P18052 CHOYP_LOC100208023.6.8 m.46002 sp PTPRA_MOUSE 24.308 325 228 8 3 317 511 827 3.29E-16 82.8 PTPRA_MOUSE reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28) Ptpra Lrp Ptpa Mus musculus (Mouse) 829 insulin receptor signaling pathway [GO:0008286]; protein phosphorylation [GO:0006468] GO:0004725; GO:0006468; GO:0008286; GO:0016021; GO:0043235; GO:0070062 0 0 0 PF00102; P23468 CHOYP_PTPRA.3.22 m.5964 sp PTPRD_HUMAN 28.67 579 334 11 15 523 1337 1906 3.29E-65 233 PTPRD_HUMAN reviewed Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) PTPRD Homo sapiens (Human) 1912 chemical synaptic transmission [GO:0007268]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron differentiation [GO:0030182]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of dendrite morphogenesis [GO:0050775]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005102; GO:0005886; GO:0005887; GO:0006470; GO:0006796; GO:0007157; GO:0007185; GO:0007268; GO:0030182; GO:0050775; GO:0050839; GO:0070062; GO:0097105 0 0 0 PF00041;PF07679;PF00102; P62498 CHOYP_AAEL_AAEL011742.1.1 m.27650 sp ERF1_XENTR 68.421 133 42 0 12 144 6 138 3.29E-60 194 ERF1_XENTR reviewed Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) etf1 TGas126k19.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 437 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" GO:0000184; GO:0005737; GO:0016149 0 0 0 PF03463;PF03464;PF03465; P86786 CHOYP_LOC101166335.1.1 m.5464 sp GIGA3_CRAGI 31.443 194 126 5 6 194 9 200 3.29E-17 80.9 GIGA3_CRAGI reviewed Gigasin-3a (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 284 0 0 0 0 0 0 Q08790 CHOYP_LOC577063.1.1 m.30814 sp BLC_VIBCH 32.222 180 98 9 11 186 3 162 3.29E-11 62.8 BLC_VIBCH reviewed Outer membrane lipoprotein Blc (Protein Vlp) blc vlp vlpA VC_A0317 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 171 0 GO:0005215; GO:0008289; GO:0009279 0 0 0 PF08212; Q0E908 CHOYP_LOC100117474.1.2 m.2609 sp HIL_DROME 26.596 470 305 12 39 488 335 784 3.29E-44 174 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q3MHN8 CHOYP_TRMT5.1.1 m.18506 sp TRM5_BOVIN 44.41 322 169 4 59 380 55 366 3.29E-89 280 TRM5_BOVIN reviewed tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) TRMT5 TRM5 Bos taurus (Bovine) 497 mitochondrial tRNA methylation [GO:0070901] GO:0005634; GO:0005759; GO:0052906; GO:0070901 0 0 0 PF02475; Q3T022 CHOYP_HSP7D.2.3 m.34785 sp SAP18_BOVIN 64 150 51 2 65 211 3 152 3.29E-63 196 SAP18_BOVIN reviewed Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p18) SAP18 Bos taurus (Bovine) 153 "mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000381; GO:0005737; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0016607; GO:0043065; GO:0048025; GO:0061574 0 0 0 PF06487; Q4A3R3 CHOYP_DMBT1.5.34 m.5444 sp DMBT1_PIG 46.98 149 71 3 190 331 332 479 3.29E-28 119 DMBT1_PIG reviewed Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) 1204 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0007275; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0035375; GO:0042589 0 0 0 PF00431;PF00530;PF00100; Q5BKL8 CHOYP_IAP1.1.4 m.25919 sp XIAP_XENTR 51.02 49 24 0 108 156 37 85 3.29E-07 52 XIAP_XENTR reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 492 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of proteolysis [GO:0045861]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005737; GO:0007275; GO:0008270; GO:0016055; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0045861; GO:0090263; GO:1990001 0 0 0 PF00653; Q5G265 CHOYP_LOC562156.1.2 m.16403 sp NETR_SAGLB 35.938 768 414 19 870 1621 165 870 3.29E-129 428 NETR_SAGLB reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Saguinus labiatus (Red-chested mustached tamarin) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5REV9 CHOYP_NPT2B.2.2 m.66878 sp NPT2B_PONAB 50 624 245 11 12 579 3 615 3.29E-178 524 NPT2B_PONAB reviewed Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) SLC34A2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 689 phosphate ion transport [GO:0006817]; sodium ion transport [GO:0006814] GO:0005886; GO:0006814; GO:0006817; GO:0015293; GO:0015321; GO:0016021; GO:0031402; GO:0042301 0 0 0 PF02690; Q5ZIQ3 CHOYP_BRAFLDRAFT_127356.1.2 m.8691 sp HNRPK_CHICK 55.422 166 71 2 4 169 69 231 3.29E-52 184 HNRPK_CHICK reviewed Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK RCJMB04_24e23 Gallus gallus (Chicken) 427 "mRNA processing [GO:0006397]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005654; GO:0005681; GO:0005737; GO:0006351; GO:0006357; GO:0006397; GO:0008380 0 0 0 PF00013;PF08067; Q6MG82 CHOYP_PRRT1.5.5 m.45186 sp PRRT1_RAT 42.52 127 63 2 133 249 174 300 3.29E-17 82.4 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6QRN8 CHOYP_PHUM_PHUM012540.4.4 m.59212 sp LAP4A_BOVIN 37.589 141 84 2 10 150 84 220 3.29E-21 89.4 LAP4A_BOVIN reviewed Lysosomal-associated transmembrane protein 4A LAPTM4A Bos taurus (Bovine) 233 transport [GO:0006810] GO:0005794; GO:0006810; GO:0016020; GO:0016021 0 0 0 PF03821; Q70E20 CHOYP_TECTA.1.1 m.47886 sp SNED1_MOUSE 40.404 99 51 3 826 922 96 188 3.29E-13 78.2 SNED1_MOUSE reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) 1403 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q82IZ1 CHOYP_BRAFLDRAFT_63281.2.2 m.46528 sp PTLH_STRAW 22.605 261 170 9 44 294 21 259 3.29E-08 57.8 PTLH_STRAW reviewed 1-deoxypentalenic acid 11-beta-hydroxylase (EC 1.14.11.35) (Neopentalenolactone biosynthesis protein H) ptlH SAV_2991 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 285 antibiotic biosynthetic process [GO:0017000]; lactone biosynthetic process [GO:1901336]; oxidation-reduction process [GO:0055114] GO:0005506; GO:0016706; GO:0017000; GO:0031418; GO:0055114; GO:1901336 PATHWAY: Antibiotic biosynthesis; neopentalenolactone biosynthesis. {ECO:0000269|PubMed:21250661}. 0 0 PF05721; Q8BLJ3 CHOYP_PLCXD2.1.1 m.18529 sp PLCX3_MOUSE 34.304 309 195 4 2 307 8 311 3.29E-68 218 PLCX3_MOUSE reviewed PI-PLC X domain-containing protein 3 Plcxd3 Mus musculus (Mouse) 321 lipid catabolic process [GO:0016042] GO:0004871; GO:0008081; GO:0016042 0 0 0 0 Q8BLQ7 CHOYP_LOC100547591.1.1 m.39311 sp CTR4_MOUSE 49.317 586 278 6 42 617 18 594 3.29E-173 511 CTR4_MOUSE reviewed Cationic amino acid transporter 4 (CAT-4) (CAT4) (Solute carrier family 7 member 4) Slc7a4 Mus musculus (Mouse) 635 0 GO:0005887; GO:0015179; GO:0015297 0 0 0 PF13520;PF13906; Q90660 CHOYP_BIRC2.2.13 m.16764 sp BIR_CHICK 26.866 402 257 9 69 452 22 404 3.29E-30 129 BIR_CHICK reviewed Inhibitor of apoptosis protein (IAP) (Inhibitor of T-cell apoptosis protein) ITA IAP1 Gallus gallus (Chicken) 611 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005737; GO:0008270; GO:0034121; GO:0043027; GO:0043066; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; Q96MM6 CHOYP_HS12A.32.33 m.63543 sp HS12B_HUMAN 39.63 270 109 8 5 225 61 325 3.29E-51 179 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99NH7 CHOYP_LOC100543859.1.1 m.25074 sp S26A5_MOUSE 32.271 722 411 9 14 731 36 683 3.29E-120 382 S26A5_MOUSE reviewed Prestin (Solute carrier family 26 member 5) Slc26a5 Pres Mus musculus (Mouse) 744 bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; cochlea development [GO:0090102]; fructose transport [GO:0015755]; negative regulation of ion transmembrane transport [GO:0034766]; positive regulation of cell motility [GO:2000147]; positive regulation of cell size [GO:0045793]; protein tetramerization [GO:0051262]; regulation of cell shape [GO:0008360]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; response to drug [GO:0042493]; response to ischemia [GO:0002931]; response to potassium ion [GO:0035864]; response to salicylic acid [GO:0009751]; response to salt [GO:1902074]; response to thyroid hormone [GO:0097066]; sensory perception of sound [GO:0007605] GO:0002931; GO:0005254; GO:0005737; GO:0005886; GO:0005887; GO:0007605; GO:0008271; GO:0008360; GO:0009751; GO:0010996; GO:0015106; GO:0015116; GO:0015301; GO:0015701; GO:0015755; GO:0016323; GO:0016328; GO:0019531; GO:0030507; GO:0034766; GO:0035864; GO:0042391; GO:0042493; GO:0045793; GO:0051262; GO:0051453; GO:0090102; GO:0097066; GO:1902074; GO:1902476; GO:2000147 0 0 0 PF01740;PF00916; Q9EQG7 CHOYP_LOC100368902.1.1 m.36630 sp ENPP5_MOUSE 41.842 380 207 8 51 422 26 399 3.29E-100 311 ENPP5_MOUSE reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-) Enpp5 Mus musculus (Mouse) 477 cell communication [GO:0007154]; nucleotide catabolic process [GO:0009166] GO:0004551; GO:0005576; GO:0005887; GO:0007154; GO:0009166; GO:0046872 0 0 0 PF01663; Q9ESN6 CHOYP_TRIM3.3.58 m.3245 sp TRIM2_MOUSE 28.571 224 133 9 99 310 536 744 3.29E-14 76.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9R1R2 CHOYP_BRAFLDRAFT_87338.4.7 m.39249 sp TRIM3_MOUSE 26.016 123 86 3 63 181 622 743 3.29E-07 53.9 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y4A5 CHOYP_TRRAP.2.2 m.19912 sp TRRAP_HUMAN 51.899 237 108 2 5 239 88 320 3.29E-69 234 TRRAP_HUMAN reviewed Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog) TRRAP PAF400 Homo sapiens (Human) 3859 "beta-catenin-TCF complex assembly [GO:1904837]; DNA repair [GO:0006281]; histone acetylation [GO:0016573]; histone deubiquitination [GO:0016578]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000125; GO:0000812; GO:0003712; GO:0005634; GO:0005654; GO:0005794; GO:0006281; GO:0006351; GO:0006355; GO:0016301; GO:0016573; GO:0016578; GO:0030914; GO:0033276; GO:0035267; GO:0043967; GO:0043968; GO:1904837 0 0 0 PF02259;PF00454; A6NK06 CHOYP_LOC100567429.1.1 m.48869 sp IRG1_HUMAN 43.197 463 253 5 30 490 5 459 3.30E-130 389 IRG1_HUMAN reviewed Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Aconitate decarboxylase 1) (Cis-aconitic acid decarboxylase) (Immune-responsive gene 1 protein) ACOD1 IRG1 Homo sapiens (Human) 481 cellular response to interferon-beta [GO:0035458]; cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-1 [GO:0071347]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to molecule of bacterial origin [GO:0071219]; cellular response to progesterone stimulus [GO:0071393]; cellular response to tumor necrosis factor [GO:0071356]; defense response [GO:0006952]; embryo implantation [GO:0007566]; inflammatory response [GO:0006954]; metabolic process [GO:0008152]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor 2 signaling pathway [GO:0034136]; negative regulation of toll-like receptor 4 signaling pathway [GO:0034144]; negative regulation of type I interferon production [GO:0032480]; positive regulation of antimicrobial humoral response [GO:0002760]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; tolerance induction to lipopolysaccharide [GO:0072573] GO:0002760; GO:0005739; GO:0006952; GO:0006954; GO:0007566; GO:0008152; GO:0032088; GO:0032480; GO:0034136; GO:0034144; GO:0035458; GO:0045824; GO:0047613; GO:0050728; GO:0071219; GO:0071222; GO:0071346; GO:0071347; GO:0071356; GO:0071393; GO:0072573; GO:2000379 0 0 0 PF03972; D9IQ16 CHOYP_LOC100892964.2.2 m.56372 sp GXN_ACRMI 25.89 309 191 10 155 452 55 336 3.30E-21 98.6 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 G5EBU4 CHOYP_CRE_22276.1.1 m.57585 sp ZAG1_CAEEL 77.049 61 12 1 8 66 505 565 3.30E-26 103 ZAG1_CAEEL reviewed Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) zag-1 F28F9.1 Caenorhabditis elegans 596 "axon guidance [GO:0007411]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of axon extension [GO:0045773]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0006351; GO:0007411; GO:0043565; GO:0045773; GO:0046872 0 0 0 PF00046;PF13912; O70277 CHOYP_BRAFLDRAFT_72273.2.2 m.51360 sp TRIM3_RAT 44.776 67 35 1 15 81 22 86 3.30E-12 72.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_85706.1.5 m.20521 sp TRIM3_RAT 28 125 83 3 31 151 622 743 3.30E-09 57.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O93310 CHOYP_BRAFLDRAFT_275667.1.1 m.17356 sp RAD21_XENLA 64.502 231 80 1 1 231 1 229 3.30E-100 308 RAD21_XENLA reviewed Double-strand-break repair protein rad21 homolog (SCC1 homolog) rad21 Xenopus laevis (African clawed frog) 629 apoptotic process [GO:0006915]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168] GO:0000228; GO:0000775; GO:0006281; GO:0006915; GO:0007059; GO:0007067; GO:0051301; GO:0071168 0 0 0 PF04824;PF04825; O95429 CHOYP_BAG3.1.1 m.15160 sp BAG4_HUMAN 38.776 98 56 1 344 437 360 457 3.30E-15 81.3 BAG4_HUMAN reviewed BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains) BAG4 SODD Homo sapiens (Human) 457 "cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [GO:2001145]; negative regulation of protein targeting to mitochondrion [GO:1903215]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell adhesion [GO:0045785]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of stress fiber assembly [GO:0051496]; protein folding [GO:0006457]; protein localization to plasma membrane [GO:0072659]; regulation of cellular response to heat [GO:1900034]; ruffle assembly [GO:0097178]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" GO:0000774; GO:0005057; GO:0005634; GO:0005829; GO:0005886; GO:0006457; GO:0010763; GO:0030838; GO:0031625; GO:0033138; GO:0033209; GO:0043066; GO:0044822; GO:0045785; GO:0051496; GO:0051897; GO:0071356; GO:0071364; GO:0072659; GO:0097178; GO:1900034; GO:1903215; GO:2001145 0 0 0 PF02179; P05149 CHOYP_contig_039436 m.44650 sp GALM_ACICA 43.103 58 33 0 89 146 28 85 3.30E-08 54.3 GALM_ACICA reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) (Type-1 mutarotase) mro Acinetobacter calcoaceticus 381 hexose metabolic process [GO:0019318] GO:0004034; GO:0019318; GO:0030246; GO:0042597 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; P16157 CHOYP_LOC100890587.1.2 m.37259 sp ANK1_HUMAN 31.021 793 523 5 45 835 4 774 3.30E-106 368 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18433 CHOYP_PTPRE.7.19 m.34309 sp PTPRA_HUMAN 30.307 683 419 22 352 1000 133 792 3.30E-82 287 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P21328 CHOYP_LOC100561123.4.28 m.3452 sp RTJK_DROME 25.333 225 137 7 2 215 640 844 3.30E-13 75.1 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P86854 CHOYP_PGCA.2.3 m.22216 sp PLCL_MYTGA 30 110 71 2 113 216 22 131 3.30E-14 70.9 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q01414 CHOYP_LOC661753.1.1 m.26561 sp ERG_LYTVA 71.91 178 37 8 70 240 1 172 3.30E-75 228 ERG_LYTVA reviewed Transcriptional regulator ERG homolog (Fragment) ERG Lytechinus variegatus (Green sea urchin) (Variegated urchin) 173 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565 0 0 0 PF00178; Q1L8G7 CHOYP_GATAD1.1.1 m.50020 sp GATD1_DANRE 49.213 254 116 4 1 253 1 242 3.30E-83 254 GATD1_DANRE reviewed GATA zinc finger domain-containing protein 1 gatad1 si:dkey-231l1.7 zgc:136582 Danio rerio (Zebrafish) (Brachydanio rerio) 242 0 GO:0003700; GO:0005634; GO:0008270; GO:0043565 0 0 0 0 Q28062 CHOYP_BRAFLDRAFT_83982.1.1 m.22467 sp PGCB_BOVIN 44.33 97 49 4 2 96 717 810 3.30E-16 78.6 PGCB_BOVIN reviewed Brevican core protein BCAN Bos taurus (Bovine) 912 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005540; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; Q2HJF4 CHOYP_BRAFLDRAFT_251802.1.1 m.66483 sp PBLD_BOVIN 49.488 293 141 3 1 293 1 286 3.30E-94 283 PBLD_BOVIN reviewed Phenazine biosynthesis-like domain-containing protein (EC 5.1.-.-) PBLD MAWBP Bos taurus (Bovine) 288 biosynthetic process [GO:0009058]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of SMAD protein import into nucleus [GO:0060392]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512] GO:0005737; GO:0009058; GO:0010633; GO:0010719; GO:0016853; GO:0030277; GO:0030512; GO:0050680; GO:0060392; GO:0060394; GO:0070062 0 0 0 PF02567; Q2PZL6 CHOYP_STAN.1.1 m.53223 sp FAT4_MOUSE 29.798 198 124 5 2 197 555 739 3.30E-14 74.7 FAT4_MOUSE reviewed Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0008543; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072006; GO:0072137; GO:0072307 0 0 0 PF00028;PF00008;PF07645;PF12661;PF02210; Q5EA50 CHOYP_LOC100373945.1.1 m.53450 sp RABEK_BOVIN 38.875 409 208 3 1 408 1 368 3.30E-106 321 RABEK_BOVIN reviewed Rab9 effector protein with kelch motifs RABEPK Bos taurus (Bovine) 372 0 GO:0005886; GO:0010008 0 0 0 PF01344;PF07646; Q64319 CHOYP_BRAFLDRAFT_220425.3.4 m.33706 sp SLC31_RAT 34.969 163 90 8 43 193 441 599 3.30E-14 73.6 SLC31_RAT reviewed "Neutral and basic amino acid transport protein rBAT (D2) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NAA-TR)" Slc3a1 Nbat Rattus norvegicus (Rat) 683 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0046982; GO:0070062 0 0 0 PF00128; Q6NVF4 CHOYP_HELB.2.2 m.53195 sp HELB_MOUSE 31.283 943 473 29 76 916 61 930 3.30E-109 372 HELB_MOUSE reviewed DNA helicase B (EC 3.6.4.12) Helb Mus musculus (Mouse) 1074 "cellular response to DNA damage stimulus [GO:0006974]; DNA-dependent DNA replication [GO:0006261]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA double-strand break processing [GO:1903775]" GO:0000398; GO:0004003; GO:0004004; GO:0005524; GO:0005634; GO:0005658; GO:0005681; GO:0005737; GO:0006260; GO:0006261; GO:0006269; GO:0006974; GO:0017116; GO:0035861; GO:0043141; GO:0044822; GO:1903775; GO:2000042 0 0 0 PF13538; Q6P1C6 CHOYP_LRIG1.2.3 m.39154 sp LRIG3_MOUSE 24.286 560 315 18 101 635 79 554 3.30E-25 115 LRIG3_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) Lrig3 Kiaa3016 Mus musculus (Mouse) 1117 otolith morphogenesis [GO:0032474] GO:0005615; GO:0005886; GO:0016021; GO:0030659; GO:0032474 0 0 0 PF07679;PF13855; Q6QLW4 CHOYP_CYC.3.5 m.47432 sp CYC_PECGU 84.404 109 17 0 27 135 1 109 3.30E-65 196 CYC_PECGU reviewed Cytochrome c 0 Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm) 109 oxidation-reduction process [GO:0055114] GO:0005758; GO:0009055; GO:0020037; GO:0046872; GO:0055114; GO:0070469 0 0 0 PF00034; Q7KRY7 CHOYP_LOC100877438.2.2 m.37290 sp LAP4_DROME 56.863 510 191 5 1 510 1 481 3.30E-174 578 LAP4_DROME reviewed Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) 1851 "anterior/posterior axis specification, follicular epithelium [GO:0030714]; asymmetric protein localization [GO:0008105]; cell fate commitment involved in pattern specification [GO:0060581]; cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; compound eye development [GO:0048749]; dorsal closure [GO:0007391]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; Malpighian tubule development [GO:0072002]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; morphogenesis of follicular epithelium [GO:0016333]; morphogenesis of larval imaginal disc epithelium [GO:0016335]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; olfactory behavior [GO:0042048]; ovarian follicle cell development [GO:0030707]; pole plasm protein localization [GO:0007318]; positive regulation of heart contraction [GO:0045823]; R3/R4 cell fate commitment [GO:0007464]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of JAK-STAT cascade [GO:0046425]; regulation of Notch signaling pathway [GO:0008593]; regulation of synapse structure or activity [GO:0050803]; sensory perception of smell [GO:0007608]; septate junction assembly [GO:0019991]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; wing disc morphogenesis [GO:0007472]; zonula adherens assembly [GO:0045186]" GO:0000122; GO:0000902; GO:0001708; GO:0001737; GO:0001738; GO:0005179; GO:0005576; GO:0005918; GO:0005923; GO:0007318; GO:0007391; GO:0007464; GO:0007472; GO:0007608; GO:0008105; GO:0008283; GO:0008285; GO:0008593; GO:0016323; GO:0016327; GO:0016328; GO:0016331; GO:0016332; GO:0016333; GO:0016334; GO:0016335; GO:0016336; GO:0019991; GO:0030100; GO:0030707; GO:0030714; GO:0031594; GO:0035088; GO:0042048; GO:0042058; GO:0042067; GO:0045169; GO:0045186; GO:0045197; GO:0045198; GO:0045571; GO:0045823; GO:0046425; GO:0048749; GO:0048863; GO:0050680; GO:0050803; GO:0051726; GO:0060581; GO:0072002; GO:0072089 0 0 0 PF13855;PF00595; Q7T392 CHOYP_T179B.1.1 m.54045 sp T179B_DANRE 23.005 213 140 7 15 218 14 211 3.30E-08 55.5 T179B_DANRE reviewed Transmembrane protein 179B tmem179b zgc:110591 Danio rerio (Zebrafish) (Brachydanio rerio) 219 0 GO:0016021 0 0 0 0 Q86YS3 CHOYP_RFIP4.2.2 m.27418 sp RFIP4_HUMAN 28.708 627 351 16 6 545 18 635 3.30E-55 199 RFIP4_HUMAN reviewed Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) RAB11FIP4 ARFO2 KIAA1821 Homo sapiens (Human) 637 cytokinesis [GO:0000910]; neural retina development [GO:0003407]; positive regulation of G1 to G0 transition [GO:1903452]; transport [GO:0006810]; viral process [GO:0016032] GO:0000910; GO:0003407; GO:0005509; GO:0005615; GO:0005768; GO:0005815; GO:0005819; GO:0006810; GO:0016032; GO:0017137; GO:0030139; GO:0030306; GO:0030496; GO:0032154; GO:0042803; GO:0048471; GO:0055038; GO:1903452 0 0 0 PF09457; Q8BH16 CHOYP_NEMVEDRAFT_V1G202192.1.1 m.17701 sp FBXL2_MOUSE 25.701 214 153 4 127 337 80 290 3.30E-09 62 FBXL2_MOUSE reviewed F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) Fbxl2 Mus musculus (Mouse) 423 protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004842; GO:0006511; GO:0006513; GO:0010506; GO:0014066; GO:0016020; GO:0016567; GO:0019005; GO:0019903; GO:0031146; GO:0036312 0 0 0 PF12937;PF13516; Q8BKF1 CHOYP_RPOM.1.1 m.15164 sp RPOM_MOUSE 53.333 435 185 6 2 427 782 1207 3.30E-154 470 RPOM_MOUSE reviewed "DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)" Polrmt Mus musculus (Mouse) 1207 transcription from mitochondrial promoter [GO:0006390] GO:0003677; GO:0003899; GO:0005739; GO:0006390; GO:0042645; GO:0044822 0 0 0 PF00940;PF14700; Q8IWZ3 CHOYP_LOC762964.1.10 m.3326 sp ANKH1_HUMAN 33.268 508 284 15 84 543 178 678 3.30E-53 200 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8K0U4 CHOYP_BRAFLDRAFT_208436.16.32 m.50927 sp HS12A_MOUSE 30.721 638 314 21 10 593 57 620 3.30E-74 253 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q99NH0 CHOYP_LOC581927.21.27 m.51411 sp ANR17_MOUSE 30.712 534 294 14 133 648 234 709 3.30E-52 199 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BXJ7 CHOYP_BRAFLDRAFT_123483.1.1 m.47326 sp AMNLS_HUMAN 29.915 351 215 12 1 334 4 340 3.30E-40 154 AMNLS_HUMAN reviewed Protein amnionless AMN UNQ513/PRO1028 Homo sapiens (Human) 453 cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; excretion [GO:0007588]; Golgi to plasma membrane protein transport [GO:0043001]; lipoprotein metabolic process [GO:0042157]; multicellular organism development [GO:0007275]; receptor-mediated endocytosis [GO:0006898] GO:0005102; GO:0005615; GO:0005886; GO:0005905; GO:0006898; GO:0007275; GO:0007588; GO:0009235; GO:0010008; GO:0015889; GO:0016021; GO:0016324; GO:0030139; GO:0042157; GO:0043001; GO:0070062 0 0 0 0 Q9C6W5 CHOYP_NEMVEDRAFT_V1G103967.1.1 m.18335 sp AB14G_ARATH 31.793 541 325 11 1 539 144 642 3.30E-89 290 AB14G_ARATH reviewed ABC transporter G family member 14 (ABC transporter ABCG.14) (AtABCG14) (White-brown complex homolog protein 14) (AtWBC14) ABCG14 WBC14 At1g31770 F27M3.2 F5M6.22 Arabidopsis thaliana (Mouse-ear cress) 648 cotyledon vascular tissue pattern formation [GO:0010588]; stem vascular tissue pattern formation [GO:0010222] GO:0005524; GO:0005886; GO:0010222; GO:0010588; GO:0016021; GO:0042626 0 0 0 PF01061;PF00005; Q9CR30 CHOYP_LOC100120391.1.1 m.25164 sp JOS2_MOUSE 52.841 176 82 1 19 194 14 188 3.30E-65 202 JOS2_MOUSE reviewed Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2) Josd2 Mus musculus (Mouse) 188 protein deubiquitination [GO:0016579] GO:0004843; GO:0005829; GO:0008242; GO:0016579 0 0 0 PF02099; Q9UBY8 CHOYP_BRAFLDRAFT_221072.1.1 m.7692 sp CLN8_HUMAN 37.358 265 164 2 13 275 15 279 3.30E-64 206 CLN8_HUMAN reviewed Protein CLN8 CLN8 C8orf61 Homo sapiens (Human) 286 adult walking behavior [GO:0007628]; age-dependent response to oxidative stress [GO:0001306]; associative learning [GO:0008306]; cellular protein catabolic process [GO:0044257]; ceramide biosynthetic process [GO:0046513]; ceramide metabolic process [GO:0006672]; cholesterol metabolic process [GO:0008203]; glutamate reuptake [GO:0051935]; lipid biosynthetic process [GO:0008610]; lipid transport [GO:0006869]; lysosome organization [GO:0007040]; mitochondrial membrane organization [GO:0007006]; musculoskeletal movement [GO:0050881]; negative regulation of apoptotic process [GO:0043066]; negative regulation of proteolysis [GO:0045861]; nervous system development [GO:0007399]; neurofilament cytoskeleton organization [GO:0060052]; neuromuscular process controlling balance [GO:0050885]; neuromuscular process controlling posture [GO:0050884]; phospholipid metabolic process [GO:0006644]; photoreceptor cell maintenance [GO:0045494]; protein catabolic process [GO:0030163]; regulation of cell size [GO:0008361]; retina development in camera-type eye [GO:0060041]; social behavior [GO:0035176]; somatic motor neuron differentiation [GO:0021523]; visual perception [GO:0007601] GO:0001306; GO:0005739; GO:0005783; GO:0005789; GO:0005793; GO:0006644; GO:0006672; GO:0006869; GO:0007006; GO:0007040; GO:0007399; GO:0007601; GO:0007628; GO:0008203; GO:0008306; GO:0008361; GO:0008610; GO:0016021; GO:0021523; GO:0030163; GO:0033116; GO:0035176; GO:0043066; GO:0044257; GO:0045494; GO:0045861; GO:0046513; GO:0050881; GO:0050884; GO:0050885; GO:0051935; GO:0060041; GO:0060052; GO:0098793 0 0 0 PF03798; Q9V4X2 CHOYP_LOC100882441.1.1 m.18234 sp PGSC2_DROME 43.407 182 99 1 33 214 6 183 3.30E-54 175 PGSC2_DROME reviewed Peptidoglycan-recognition protein SC2 (EC 3.5.1.28) PGRP-SC2 CG14745 Drosophila melanogaster (Fruit fly) 184 immune response [GO:0006955]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; peptidoglycan catabolic process [GO:0009253] GO:0005576; GO:0006955; GO:0008270; GO:0008745; GO:0009253; GO:0042834; GO:0045087; GO:0045824 0 0 cd06583; PF01510; Q9Y238 CHOYP_SRC.1.2 m.2505 sp DLEC1_HUMAN 34.323 303 176 9 51 332 1369 1669 3.30E-39 155 DLEC1_HUMAN reviewed Deleted in lung and esophageal cancer protein 1 (Deleted in lung cancer protein 1) (DLC-1) DLEC1 DLC1 Homo sapiens (Human) 1755 negative regulation of cell proliferation [GO:0008285] GO:0005737; GO:0008285 0 0 0 0 A2ARZ3 CHOYP_LRRX1.9.11 m.49468 sp FSIP2_MOUSE 30.938 320 161 14 15 321 35 307 3.31E-22 109 FSIP2_MOUSE reviewed Fibrous sheath-interacting protein 2 Fsip2 Mus musculus (Mouse) 6995 0 GO:0005739; GO:0031514 0 0 0 PF15783; B4PD96 CHOYP_PEAR1.8.16 m.41400 sp CUE_DROYA 40.58 69 31 3 114 181 373 432 3.31E-07 53.1 CUE_DROYA reviewed Protein cueball cue GE20954 Drosophila yakuba (Fruit fly) 644 oogenesis [GO:0048477]; spermatogenesis [GO:0007283] GO:0005509; GO:0005886; GO:0007283; GO:0016021; GO:0048477 0 0 0 PF00058; D2GXS7 CHOYP_BRAFLDRAFT_241726.20.22 m.52065 sp TRIM2_AILME 26.667 210 144 5 233 437 540 744 3.31E-11 68.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_BRAFLDRAFT_85432.1.1 m.39190 sp HMCN1_MOUSE 23.768 345 213 14 181 501 1509 1827 3.31E-06 54.7 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O16277 CHOYP_LOC100635715.9.9 m.65846 sp H16_CAEEL 55.446 101 44 1 39 138 25 125 3.31E-26 103 H16_CAEEL reviewed Putative histone H1.6 (Histone H1-like protein 6) hil-6 F59A7.4 Caenorhabditis elegans 190 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; O35613 CHOYP_LOC100368330.2.2 m.39954 sp DAXX_MOUSE 39.713 209 118 3 546 749 186 391 3.31E-41 167 DAXX_MOUSE reviewed Death domain-associated protein 6 (Daxx) Daxx Mus musculus (Mouse) 739 "androgen receptor signaling pathway [GO:0030521]; apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron death [GO:1901216]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of multicellular organism growth [GO:0040014]; regulation of protein ubiquitination [GO:0031396]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000281; GO:0000775; GO:0000792; GO:0001934; GO:0002039; GO:0003713; GO:0003714; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0006334; GO:0006338; GO:0006351; GO:0006355; GO:0008134; GO:0016569; GO:0016605; GO:0019899; GO:0019901; GO:0030295; GO:0030521; GO:0031396; GO:0031625; GO:0040014; GO:0042393; GO:0042803; GO:0043066; GO:0045860; GO:0045892; GO:0045944; GO:0047485; GO:0050681; GO:0070603; GO:0097190; GO:1901216; GO:2001235 0 0 cd13151; PF03344; O70277 CHOYP_BRAFLDRAFT_88223.5.22 m.23899 sp TRIM3_RAT 22.538 528 338 15 65 558 115 605 3.31E-14 79.3 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P16157 CHOYP_LOC100635111.2.13 m.3790 sp ANK1_HUMAN 36.545 301 190 1 8 307 255 555 3.31E-52 188 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P50867 CHOYP_LOC100377160.2.2 m.55835 sp CYSK_EMENI 60.061 328 127 3 56 379 34 361 3.31E-138 401 CYSK_EMENI reviewed Cysteine synthase 1 (CS 1) (EC 2.5.1.47) (O-acetylserine (thiol)-lyase 1) (OAS-TL 1) (O-acetylserine sulfhydrylase 1) cysB cysE AN8057 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 370 cellular amino acid biosynthetic process [GO:0008652]; cysteine biosynthetic process from serine [GO:0006535] GO:0004124; GO:0005737; GO:0005739; GO:0006535; GO:0008652; GO:0016740; GO:0030170 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2. {ECO:0000305|PubMed:17482430}. 0 0 PF00291; Q03278 CHOYP_LOC100890133.1.3 m.16210 sp PO21_NASVI 28.111 217 139 5 1 204 449 661 3.31E-13 74.7 PO21_NASVI reviewed Retrovirus-related Pol polyprotein from type-1 retrotransposable element R2 (Retrovirus-related Pol polyprotein from type I retrotransposable element R2) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] (Fragment) 0 Nasonia vitripennis (Parasitic wasp) 1025 0 GO:0003964; GO:0004519; GO:0046872 0 0 0 PF00078; Q2S2F5 CHOYP_BRAFLDRAFT_120654.1.1 m.29771 sp KYNB_SALRD 23.581 229 151 5 18 246 1 205 3.31E-13 70.5 KYNB_SALRD reviewed Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) kynB SRU_1503 Salinibacter ruber (strain DSM 13855 / M31) 212 anthranilate metabolic process [GO:0043420]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0004061; GO:0004328; GO:0019441; GO:0043420 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. {ECO:0000255|HAMAP-Rule:MF_01969}. 0 0 PF04199; Q460N5 CHOYP_DSPP.5.8 m.37255 sp PAR14_HUMAN 29.362 235 142 5 1593 1818 1029 1248 3.31E-18 96.3 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4KLT3 CHOYP_TRM44.1.1 m.3849 sp TRM44_XENLA 42.089 651 314 13 40 645 20 652 3.31E-157 471 TRM44_XENLA reviewed Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) trmt44 mettl19 Xenopus laevis (African clawed frog) 668 tRNA processing [GO:0008033] GO:0005737; GO:0008033; GO:0008168; GO:0046872 0 0 0 PF07757; Q5EA79 CHOYP_BRAFLDRAFT_284587.1.3 m.284 sp GALM_BOVIN 42.899 338 188 4 14 351 9 341 3.31E-89 274 GALM_BOVIN reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM Bos taurus (Bovine) 342 galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006] GO:0004034; GO:0005737; GO:0006006; GO:0006012; GO:0030246; GO:0070062 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; Q5JR59 CHOYP_LOC763960.2.2 m.45420 sp MTUS2_HUMAN 29.235 366 234 6 1350 1705 995 1345 3.31E-35 151 MTUS2_HUMAN reviewed Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa) MTUS2 CAZIP KIAA0774 TIP150 Homo sapiens (Human) 1369 0 GO:0005634; GO:0005737; GO:0005874; GO:0008017; GO:0042803 0 0 0 0 Q5R8P5 CHOYP_LOC100175101.1.1 m.44230 sp SHLB1_PONAB 65.922 179 61 0 13 191 6 184 3.31E-85 259 SHLB1_PONAB reviewed Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) SH3GLB1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 365 'de novo' posttranslational protein folding [GO:0051084]; apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; protein localization to vacuolar membrane [GO:1903778] GO:0000139; GO:0000421; GO:0005504; GO:0005741; GO:0006654; GO:0006915; GO:0008654; GO:0030496; GO:0031410; GO:0042171; GO:0043234; GO:0043552; GO:0048102; GO:0051084; GO:1900740; GO:1902254; GO:1902255; GO:1903778; GO:2000786 0 0 0 PF03114;PF14604; Q5RFZ7 CHOYP_FAM167A.2.2 m.55884 sp F167A_DANRE 34.694 98 61 2 107 201 105 202 3.31E-10 60.5 F167A_DANRE reviewed Protein FAM167A fam167a si:ch211-261f7.2 Danio rerio (Zebrafish) (Brachydanio rerio) 204 0 0 0 0 0 PF11652; Q5XG92 CHOYP_SI_CH211-93F2.1.1.4 m.20313 sp EST4A_HUMAN 34.286 560 302 18 297 825 22 546 3.31E-82 278 EST4A_HUMAN reviewed Carboxylesterase 4A (EC 3.1.1.-) CES4A CES8 UNQ440/PRO873 Homo sapiens (Human) 561 0 GO:0005615; GO:0052689 0 0 0 PF00135; Q63184 CHOYP_LOC100208179.3.3 m.59726 sp E2AK2_RAT 33.432 338 175 13 18 351 197 488 3.31E-36 142 E2AK2_RAT reviewed "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2)" Eif2ak2 Prkr Rattus norvegicus (Rat) 513 "activation of MAPKK activity [GO:0000186]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to exogenous dsRNA [GO:0043330]; response to interferon-alpha [GO:0035455]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to organic substance [GO:0010033]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to vitamin E [GO:0033197]; transcription, DNA-templated [GO:0006351]" GO:0000186; GO:0001819; GO:0003725; GO:0004672; GO:0004674; GO:0004715; GO:0005524; GO:0005634; GO:0005737; GO:0006351; GO:0006468; GO:0009612; GO:0009615; GO:0009636; GO:0010033; GO:0010998; GO:0017148; GO:0032496; GO:0032722; GO:0032874; GO:0033197; GO:0033689; GO:0035455; GO:0043065; GO:0043330; GO:0045071; GO:0045087; GO:0046777; GO:0048471; GO:0051092; GO:0051607; GO:1900225; GO:1901224; GO:1901532; GO:1902033; GO:1902036 0 0 0 PF00035;PF00069; Q6AY20 CHOYP_BRAFLDRAFT_118619.1.2 m.4411 sp MPRD_RAT 27.473 182 112 6 57 224 61 236 3.31E-07 53.5 MPRD_RAT reviewed Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) M6pr Rattus norvegicus (Rat) 278 0 GO:0005537; GO:0005765; GO:0005802; GO:0015578; GO:0016021 0 0 0 PF02157; Q6R7A0 CHOYP_Y121.1.1 m.30580 sp Y121_OSHVF 99.505 202 1 0 1 202 1 202 3.31E-147 410 Y121_OSHVF reviewed Putative zinc finger protein ORF121 ORF121 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 215 0 GO:0008270 0 0 0 PF14634; Q7KRY7 CHOYP_LOC100877438.1.2 m.4705 sp LAP4_DROME 54.393 535 187 6 1 532 1 481 3.31E-171 570 LAP4_DROME reviewed Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) 1851 "anterior/posterior axis specification, follicular epithelium [GO:0030714]; asymmetric protein localization [GO:0008105]; cell fate commitment involved in pattern specification [GO:0060581]; cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; compound eye development [GO:0048749]; dorsal closure [GO:0007391]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; Malpighian tubule development [GO:0072002]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; morphogenesis of follicular epithelium [GO:0016333]; morphogenesis of larval imaginal disc epithelium [GO:0016335]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; olfactory behavior [GO:0042048]; ovarian follicle cell development [GO:0030707]; pole plasm protein localization [GO:0007318]; positive regulation of heart contraction [GO:0045823]; R3/R4 cell fate commitment [GO:0007464]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of JAK-STAT cascade [GO:0046425]; regulation of Notch signaling pathway [GO:0008593]; regulation of synapse structure or activity [GO:0050803]; sensory perception of smell [GO:0007608]; septate junction assembly [GO:0019991]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; wing disc morphogenesis [GO:0007472]; zonula adherens assembly [GO:0045186]" GO:0000122; GO:0000902; GO:0001708; GO:0001737; GO:0001738; GO:0005179; GO:0005576; GO:0005918; GO:0005923; GO:0007318; GO:0007391; GO:0007464; GO:0007472; GO:0007608; GO:0008105; GO:0008283; GO:0008285; GO:0008593; GO:0016323; GO:0016327; GO:0016328; GO:0016331; GO:0016332; GO:0016333; GO:0016334; GO:0016335; GO:0016336; GO:0019991; GO:0030100; GO:0030707; GO:0030714; GO:0031594; GO:0035088; GO:0042048; GO:0042058; GO:0042067; GO:0045169; GO:0045186; GO:0045197; GO:0045198; GO:0045571; GO:0045823; GO:0046425; GO:0048749; GO:0048863; GO:0050680; GO:0050803; GO:0051726; GO:0060581; GO:0072002; GO:0072089 0 0 0 PF13855;PF00595; Q8CEG5 CHOYP_LOC100373982.2.2 m.64354 sp CC28B_MOUSE 42.202 109 52 2 91 188 78 186 3.31E-20 87 CC28B_MOUSE reviewed Coiled-coil domain-containing protein 28B Ccdc28b Mus musculus (Mouse) 200 cilium assembly [GO:0042384] GO:0005737; GO:0005813; GO:0042384 0 0 0 PF13270; Q8NFZ3 CHOYP_LOC100644613.1.1 m.55010 sp NLGNY_HUMAN 31.911 586 333 19 24 578 47 597 3.31E-83 281 NLGNY_HUMAN reviewed "Neuroligin-4, Y-linked (Neuroligin Y)" NLGN4Y KIAA0951 Homo sapiens (Human) 816 learning [GO:0007612]; modulation of synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] GO:0004872; GO:0005887; GO:0007158; GO:0007416; GO:0007612; GO:0009986; GO:0014069; GO:0030054; GO:0035176; GO:0042043; GO:0045202; GO:0045211; GO:0050804; GO:0050839; GO:0052689; GO:0071625; GO:0097110 0 0 0 PF00135; Q90828 CHOYP_LOC585963.2.2 m.37123 sp DC1L1_CHICK 50.607 494 202 9 6 469 28 509 3.31E-167 484 DC1L1_CHICK reviewed "Cytoplasmic dynein 1 light intermediate chain 1 (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (LIC57/59)" DYNC1LI1 DNCLI1 Gallus gallus (Chicken) 515 microtubule-based movement [GO:0007018]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; transport [GO:0006810] GO:0000776; GO:0000922; GO:0003777; GO:0005524; GO:0005654; GO:0005737; GO:0005813; GO:0005868; GO:0005874; GO:0005886; GO:0006810; GO:0007018; GO:0044822; GO:0090267 0 0 0 PF05783; Q96RW7 CHOYP_BRAFLDRAFT_85664.5.10 m.27729 sp HMCN1_HUMAN 48.538 342 176 0 299 640 4528 4869 3.31E-108 366 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99NH0 CHOYP_LOC755521.21.28 m.53681 sp ANR17_MOUSE 41.189 471 240 17 258 707 231 685 3.31E-79 280 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9D7P6 CHOYP_BRAFLDRAFT_115833.1.1 m.17980 sp ISCU_MOUSE 74.667 150 35 2 3 149 10 159 3.31E-78 232 ISCU_MOUSE reviewed "Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein)" Iscu Nifun Mus musculus (Mouse) 168 [2Fe-2S] cluster assembly [GO:0044571]; cellular iron ion homeostasis [GO:0006879]; protein maturation by iron-sulfur cluster transfer [GO:0097428] GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006879; GO:0008198; GO:0032947; GO:0036455; GO:0044571; GO:0051537; GO:0051539; GO:0097428 0 0 cd06664; PF01592; Q9EQD0 CHOYP_LOC100313610.1.2 m.9571 sp FZD5_MOUSE 68.627 153 43 3 27 176 24 174 3.31E-68 221 FZD5_MOUSE reviewed Frizzled-5 (Fz-5) (mFz5) Fzd5 Mus musculus (Mouse) 585 "angiogenesis [GO:0001525]; anterior/posterior axis specification, embryo [GO:0008595]; apoptotic process involved in morphogenesis [GO:0060561]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; canonical Wnt signaling pathway [GO:0060070]; cell maturation [GO:0048469]; cellular response to molecule of bacterial origin [GO:0071219]; chorionic trophoblast cell differentiation [GO:0060718]; embryonic axis specification [GO:0000578]; embryonic camera-type eye development [GO:0031076]; embryonic camera-type eye morphogenesis [GO:0048596]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of cell proliferation [GO:0008285]; non-canonical Wnt signaling pathway [GO:0035567]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic camera-type eye development [GO:0031077]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of chorionic trophoblast cell proliferation [GO:1901382]; regulation of mitophagy [GO:1903146]; Spemann organizer formation [GO:0060061]; syncytiotrophoblast cell differentiation involved in labyrinthine layer development [GO:0060715]; T cell differentiation in thymus [GO:0033077]; vasculature development [GO:0001944]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]" GO:0000139; GO:0000578; GO:0001525; GO:0001944; GO:0002726; GO:0004930; GO:0005794; GO:0005886; GO:0005923; GO:0008285; GO:0008595; GO:0009986; GO:0016021; GO:0016055; GO:0017147; GO:0019901; GO:0031076; GO:0031077; GO:0031625; GO:0032729; GO:0033077; GO:0035567; GO:0042813; GO:0043507; GO:0044332; GO:0045944; GO:0048469; GO:0048471; GO:0048596; GO:0060061; GO:0060070; GO:0060561; GO:0060670; GO:0060715; GO:0060716; GO:0060718; GO:0060828; GO:0071219; GO:1901382; GO:1903146; GO:1903955; GO:2000810 0 0 0 PF01534;PF01392; Q9HCD5 CHOYP_BRAFLDRAFT_118803.1.1 m.14069 sp NCOA5_HUMAN 32.553 470 189 13 251 604 104 561 3.31E-43 167 NCOA5_HUMAN reviewed Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) NCOA5 KIAA1637 Homo sapiens (Human) 579 "glucose homeostasis [GO:0042593]; negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0005615; GO:0005634; GO:0006351; GO:0006355; GO:0015629; GO:0042593; GO:0044822; GO:0046627 0 0 0 0 Q9MZL5 CHOYP_CACB1.1.1 m.44892 sp CACB2_BOVIN 55.319 94 39 2 19 110 15 107 3.31E-26 104 CACB2_BOVIN reviewed Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) CACNB2 Bos taurus (Bovine) 603 calcium ion import [GO:0070509]; chemical synaptic transmission [GO:0007268]; neuromuscular junction development [GO:0007528]; positive regulation of calcium ion transport [GO:0051928]; regulation of voltage-gated calcium channel activity [GO:1901385]; visual perception [GO:0007601] GO:0005891; GO:0007268; GO:0007528; GO:0007601; GO:0008331; GO:0051928; GO:0070509; GO:1901385; GO:1990454 0 0 0 PF00625;PF12052; Q9WVB4 CHOYP_TLR3.1.6 m.27157 sp SLIT3_MOUSE 29.07 172 112 3 128 298 319 481 3.31E-12 72 SLIT3_MOUSE reviewed Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) 1523 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; organ morphogenesis [GO:0009887]; regulation of axonogenesis [GO:0050770]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385] GO:0005102; GO:0005509; GO:0005578; GO:0005615; GO:0007411; GO:0008201; GO:0008285; GO:0009887; GO:0010629; GO:0030308; GO:0032870; GO:0035385; GO:0048495; GO:0048846; GO:0050770; GO:0050919; GO:0051414; GO:0061364; GO:0070100 0 0 0 PF00008;PF12661;PF02210;PF13855;PF01463;PF01462; Q9Y4R7 CHOYP_LOC578867.2.5 m.21631 sp TTLL3_HUMAN 46.591 440 218 7 648 1077 179 611 3.31E-126 411 TTLL3_HUMAN reviewed Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) 772 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; protein polyglycylation [GO:0018094] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0035082; GO:0042384; GO:0070735; GO:0070736 0 0 0 PF03133; A3DC27 CHOYP_COL6A6.1.2 m.39071 sp RSGI2_CLOTH 36.199 221 120 5 81 297 306 509 3.32E-12 73.6 RSGI2_CLOTH reviewed Anti-sigma-I factor RsgI2 rsgI2 Cthe_0267 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 671 carbohydrate metabolic process [GO:0005975] GO:0005886; GO:0005975; GO:0016021; GO:0030248; GO:0046872 0 0 0 PF00942;PF12791; A4IJ15 CHOYP_SYWC.5.5 m.54887 sp CFA97_XENTR 33.096 281 131 11 188 443 218 466 3.32E-21 99.4 CFA97_XENTR reviewed Cilia- and flagella-associated protein 97 cfap97 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 467 0 0 0 0 0 PF13879; B3EWZ3 CHOYP_SSPO.13.14 m.59831 sp CADN_ACRMI 46.429 112 53 3 32 138 406 515 3.32E-20 91.7 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; H2A0M7 CHOYP_PLSP.4.5 m.44386 sp PLSP_PINMG 42.751 676 319 16 73 708 60 707 3.32E-138 431 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O35608 CHOYP_ANGP2.4.5 m.55842 sp ANGP2_MOUSE 33.994 353 220 8 85 430 148 494 3.32E-50 181 ANGP2_MOUSE reviewed Angiopoietin-2 (ANG-2) Angpt2 Agpt2 Mus musculus (Mouse) 496 angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; blood vessel remodeling [GO:0001974]; cellular response to growth factor stimulus [GO:0071363]; endoderm development [GO:0007492]; germ cell development [GO:0007281]; glomerulus vasculature development [GO:0072012]; hemopoiesis [GO:0030097]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of positive chemotaxis [GO:0050928]; organ regeneration [GO:0031100]; positive regulation of angiogenesis [GO:0045766]; regulation of angiogenesis [GO:0045765]; response to activity [GO:0014823]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to radiation [GO:0009314]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0001666; GO:0001974; GO:0005172; GO:0005615; GO:0005634; GO:0005886; GO:0007169; GO:0007281; GO:0007492; GO:0009314; GO:0009612; GO:0009749; GO:0010812; GO:0014070; GO:0014823; GO:0016525; GO:0030097; GO:0030971; GO:0031100; GO:0042995; GO:0043537; GO:0045765; GO:0045766; GO:0046872; GO:0048014; GO:0048514; GO:0050928; GO:0060135; GO:0071363; GO:0072012 0 0 0 PF00147; P10394 CHOYP_LOC100708199.6.6 m.57028 sp POL4_DROME 28.989 959 578 22 343 1229 286 1213 3.32E-111 385 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P23469 CHOYP_PTPRE.1.19 m.292 sp PTPRE_HUMAN 33.501 597 338 19 513 1072 115 689 3.32E-84 291 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P79371 CHOYP_BRAFLDRAFT_114735.1.1 m.27481 sp SOX_RABIT 49.254 268 129 4 1 262 118 384 3.32E-81 252 SOX_RABIT reviewed Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) PIPOX PSO SOX Oryctolagus cuniculus (Rabbit) 390 L-lysine catabolic process to acetyl-CoA via L-pipecolate [GO:0033514]; oxidation-reduction process [GO:0055114]; tetrahydrofolate metabolic process [GO:0046653] GO:0005777; GO:0008115; GO:0033514; GO:0046653; GO:0050031; GO:0055114 0 0 0 PF01266; P86854 CHOYP_NEMVEDRAFT_V1G238062.1.6 m.4524 sp PLCL_MYTGA 26.829 164 105 4 6 169 8 156 3.32E-15 73.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q01583 CHOYP_LOC100651358.1.1 m.22804 sp DGK1_DROME 46.656 628 233 15 1 592 5 566 3.32E-161 501 DGK1_DROME reviewed Diacylglycerol kinase 1 (DAG kinase 1) (DGK 1) (Diglyceride kinase 1) (EC 2.7.1.107) Dgk DGK1 CG34361 Drosophila melanogaster (Fruit fly) 1211 intracellular signal transduction [GO:0035556]; phosphorylation [GO:0016310]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205] GO:0004143; GO:0005509; GO:0005524; GO:0005622; GO:0007205; GO:0016310; GO:0035556 0 0 0 PF00130;PF14513;PF00609;PF00781; Q02427 CHOYP_RBP1.2.2 m.37449 sp RBP1_DROME 70.886 79 23 0 12 90 3 81 3.32E-37 126 RBP1_DROME reviewed RNA-binding protein 1 Rbp1 Rbp11 CG17136 Drosophila melanogaster (Fruit fly) 144 "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of gene expression [GO:0010468]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0000398; GO:0001178; GO:0003729; GO:0005634; GO:0006376; GO:0008380; GO:0010468; GO:0031440; GO:0035327; GO:0045292 0 0 0 PF00076; Q05609 CHOYP_BRAFLDRAFT_81532.1.1 m.58865 sp CTR1_ARATH 28.198 344 161 17 79 398 539 820 3.32E-19 96.3 CTR1_ARATH reviewed Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1) CTR1 At5g03730 F17C15_150 Arabidopsis thaliana (Mouse-ear cress) 821 cellular response to iron ion [GO:0071281]; ethylene-activated signaling pathway [GO:0009873]; gibberellin biosynthetic process [GO:0009686]; negative regulation of ethylene-activated signaling pathway [GO:0010105]; protein autophosphorylation [GO:0046777]; regulation of post-embryonic root development [GO:2000069]; regulation of stem cell division [GO:2000035]; regulation of timing of transition from vegetative to reproductive phase [GO:0048510]; response to ethylene [GO:0009723]; response to fructose [GO:0009750]; response to hypoxia [GO:0001666]; response to sucrose [GO:0009744]; sugar mediated signaling pathway [GO:0010182] GO:0001666; GO:0004674; GO:0004712; GO:0005524; GO:0005789; GO:0009686; GO:0009723; GO:0009744; GO:0009750; GO:0009873; GO:0010105; GO:0010182; GO:0046777; GO:0048510; GO:0071281; GO:2000035; GO:2000069 0 0 0 PF07714; Q3TLD5 CHOYP_LOC100371571.1.1 m.2417 sp RMP_MOUSE 40.541 185 103 3 6 184 28 211 3.32E-34 136 RMP_MOUSE reviewed Unconventional prefoldin RPB5 interactor (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) Uri1 Nnx3 Ppp1r19 Rmp Uri Mus musculus (Mouse) 531 "cellular response to growth factor stimulus [GO:0071363]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of cell growth [GO:0001558]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to virus [GO:0009615]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001106; GO:0001558; GO:0003682; GO:0004864; GO:0005634; GO:0005665; GO:0005737; GO:0005739; GO:0006351; GO:0006357; GO:0009615; GO:0010923; GO:0019212; GO:0030425; GO:0043231; GO:0051219; GO:0071363; GO:0071383; GO:2001243 0 0 0 PF02996; Q502M6 CHOYP_LOC755521.10.28 m.38312 sp ANR29_DANRE 37.805 164 102 0 1 164 65 228 3.32E-31 117 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5XGP7 CHOYP_SKA2A.2.3 m.50778 sp SKA2A_XENLA 38.136 118 65 2 12 122 99 215 3.32E-16 83.2 SKA2A_XENLA reviewed Src kinase-associated phosphoprotein 2-A skap2-a Xenopus laevis (African clawed frog) 330 B cell activation [GO:0042113] GO:0005737; GO:0042113 0 0 0 PF00169;PF00018; Q6NTJ3 CHOYP_GWL.1.1 m.9656 sp GWL_XENLA 49.793 241 100 3 523 743 648 887 3.32E-65 236 GWL_XENLA reviewed Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) mastl gw gwl Xenopus laevis (African clawed frog) 887 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; negative regulation of protein phosphatase type 2A activity [GO:0034048]; protein autophosphorylation [GO:0046777] GO:0000086; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006974; GO:0007067; GO:0032154; GO:0034048; GO:0046777; GO:0051301; GO:0051721 0 0 0 PF00069; Q6NZL8 CHOYP_LOC100879487.3.3 m.33049 sp SCUB1_MOUSE 27.108 332 207 7 75 389 515 828 3.32E-23 110 SCUB1_MOUSE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) 1018 protein homooligomerization [GO:0051260] GO:0005509; GO:0005615; GO:0009897; GO:0009986; GO:0019897; GO:0046982; GO:0051260 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q7K237 CHOYP_GBLP.1.7 m.4942 sp C1GLT_DROME 42.222 360 186 8 38 391 4 347 3.32E-95 293 C1GLT_DROME reviewed "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GalTA CG9520 Drosophila melanogaster (Fruit fly) 388 "central nervous system morphogenesis [GO:0021551]; glycolipid biosynthetic process [GO:0009247]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; O-glycan processing, core 1 [GO:0016267]; protein glycosylation [GO:0006486]; regulation of filopodium assembly [GO:0051489]" GO:0006486; GO:0009247; GO:0016021; GO:0016263; GO:0016267; GO:0021551; GO:0046872; GO:0048531; GO:0051489; GO:1902037 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02434; Q7Z0T3 CHOYP_TRIADDRAFT_32712.2.4 m.28430 sp TEMPT_APLCA 50.485 103 48 3 2 102 7 108 3.32E-27 100 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q86U86 CHOYP_PB1.5.6 m.26095 sp PB1_HUMAN 47.368 95 33 2 21 115 1384 1461 3.32E-16 79.7 PB1_HUMAN reviewed Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 "chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0003682; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0008285; GO:0016569; GO:0090544 0 0 0 PF01426;PF00439;PF00505; Q8NE09 CHOYP_TRIADDRAFT_64391.1.3 m.37301 sp RGS22_HUMAN 36.458 96 55 1 1082 1177 1045 1134 3.32E-12 75.1 RGS22_HUMAN reviewed Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) 1264 negative regulation of signal transduction [GO:0009968] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0009968 0 0 0 PF00615; Q8NFU7 CHOYP_TET1.1.1 m.9858 sp TET1_HUMAN 40.838 764 379 24 419 1153 1417 2136 3.32E-143 480 TET1_HUMAN reviewed Methylcytosine dioxygenase TET1 (EC 1.14.11.n2) (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein) TET1 CXXC6 KIAA1676 LCX Homo sapiens (Human) 2136 "covalent chromatin modification [GO:0016569]; DNA demethylation [GO:0080111]; inner cell mass cell differentiation [GO:0001826]; negative regulation of methylation-dependent chromatin silencing [GO:0090310]; positive regulation of cell proliferation [GO:0008284]; positive regulation of histone methylation [GO:0031062]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein O-linked glycosylation [GO:0006493]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]" GO:0001826; GO:0005506; GO:0005634; GO:0006351; GO:0006493; GO:0008270; GO:0008284; GO:0016569; GO:0019827; GO:0031062; GO:0043566; GO:0045944; GO:0070579; GO:0080111; GO:0090310 0 0 0 PF12851;PF02008; Q8R512 CHOYP_LOC100185765.1.2 m.8863 sp UBX11_RAT 34.59 451 242 9 92 540 68 467 3.32E-81 265 UBX11_RAT reviewed UBX domain-containing protein 11 (Socius) (UBX domain-containing protein 5) Ubxn11 Soc Ubxd5 Rattus norvegicus (Rat) 485 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0005737; GO:0005856; GO:0043130; GO:0043161 0 0 0 PF08059;PF00789; Q9LDH0 CHOYP_XYLT.1.2 m.46918 sp XYLT_ARATH 25.547 411 221 14 119 457 137 534 3.32E-31 129 XYLT_ARATH reviewed "Beta-(1,2)-xylosyltransferase (EC 2.4.2.38)" XYLT At5g55500 MTE17.21 Arabidopsis thaliana (Mouse-ear cress) 534 "posttranslational protein targeting to membrane, translocation [GO:0031204]; protein N-linked glycosylation [GO:0006487]" GO:0000139; GO:0005794; GO:0005797; GO:0006487; GO:0016021; GO:0031204; GO:0032580; GO:0042285; GO:0050513 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04577; Q9PWA1 CHOYP_AGAP_AGAP007127.1.1 m.55750 sp RGS20_CHICK 61.084 203 68 3 54 247 9 209 3.32E-70 218 RGS20_CHICK reviewed Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) RGS20 Gallus gallus (Chicken) 218 "cell death [GO:0008219]; cell differentiation [GO:0030154]; cellular response to organic cyclic compound [GO:0071407]; dorsal/ventral axis specification [GO:0009950]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of catenin import into nucleus [GO:0035412]; regulation of transcription, DNA-templated [GO:0006355]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0005096; GO:0005634; GO:0005802; GO:0005881; GO:0005886; GO:0005938; GO:0006355; GO:0008013; GO:0008219; GO:0009950; GO:0014069; GO:0016023; GO:0019901; GO:0030154; GO:0030877; GO:0035412; GO:0070016; GO:0071407; GO:0090090; GO:0090244 0 0 0 PF00615; Q9UA35 CHOYP_NEMVEDRAFT_V1G135437.1.2 m.26454 sp S28A3_EPTST 41.448 649 327 12 21 662 8 610 3.32E-161 482 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; Q9UI14 CHOYP_BRAFLDRAFT_125634.1.1 m.14767 sp PRAF1_HUMAN 49.359 156 78 1 44 199 31 185 3.32E-50 164 PRAF1_HUMAN reviewed Prenylated Rab acceptor protein 1 (PRA1 family protein 1) RABAC1 PRA1 PRAF1 Homo sapiens (Human) 185 0 GO:0005794; GO:0005886; GO:0008021; GO:0016020; GO:0016021; GO:0030054; GO:0042802 0 0 0 PF03208; Q9Y5Y6 CHOYP_ST14.1.2 m.29649 sp ST14_HUMAN 28.505 214 110 8 13 209 300 487 3.32E-09 61.6 ST14_HUMAN reviewed Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 Homo sapiens (Human) 855 epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; proteolysis [GO:0006508] GO:0001843; GO:0004252; GO:0005615; GO:0005886; GO:0005887; GO:0006508; GO:0008236; GO:0016323; GO:0019897; GO:0030216; GO:0060672; GO:0070062 0 0 cd00190; PF00431;PF00057;PF01390;PF00089; A4QNP7 CHOYP_DMTA2.1.1 m.62196 sp DMTA2_XENTR 42.135 356 137 12 74 364 35 386 3.33E-65 218 DMTA2_XENTR reviewed Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5) dmrta2 dmrt5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 437 sex differentiation [GO:0007548] GO:0000987; GO:0003700; GO:0005634; GO:0007548; GO:0042803; GO:0046872 0 0 0 PF00751;PF03474; O08746 CHOYP_CO6A5.6.6 m.56702 sp MATN2_MOUSE 36.066 122 71 3 1 117 718 837 3.33E-16 76.3 MATN2_MOUSE reviewed Matrilin-2 Matn2 Mus musculus (Mouse) 956 axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; response to axon injury [GO:0048678] GO:0001764; GO:0005509; GO:0005578; GO:0005604; GO:0007411; GO:0008347; GO:0031104; GO:0031175; GO:0048678 0 0 0 PF07645;PF10393;PF00092; O75445 CHOYP_USH2A.4.6 m.58707 sp USH2A_HUMAN 30.99 313 134 10 431 664 575 884 3.33E-31 138 USH2A_HUMAN reviewed Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF02210;PF00055; O88967 CHOYP_AAEL_AAEL010241.1.1 m.46132 sp YMEL1_MOUSE 37.908 736 391 14 1 694 1 712 3.33E-153 464 YMEL1_MOUSE reviewed ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (YME1-like protein 1) Yme1l1 Mus musculus (Mouse) 715 cell proliferation [GO:0008283]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrion organization [GO:0007005] GO:0004176; GO:0004222; GO:0005524; GO:0005654; GO:0005739; GO:0005743; GO:0006515; GO:0007005; GO:0008237; GO:0008283; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00004;PF01434; P02637 CHOYP_SCP.5.12 m.49390 sp SCP_MIZYE 44.286 210 80 3 41 250 2 174 3.33E-57 183 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P16157 CHOYP_AASI_1435.24.35 m.54482 sp ANK1_HUMAN 36.139 404 242 3 549 952 173 560 3.33E-54 210 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_AFUA_1G01020.44.50 m.63372 sp ANK1_HUMAN 30.04 253 128 6 500 704 224 475 3.33E-16 87 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_LOC100639010.9.9 m.61759 sp ANK1_HUMAN 32.7 474 315 1 390 863 40 509 3.33E-72 263 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P37837 CHOYP_TALDO.1.2 m.18909 sp TALDO_HUMAN 68.75 320 100 0 1 320 11 330 3.33E-165 466 TALDO_HUMAN reviewed Transaldolase (EC 2.2.1.2) TALDO1 TAL TALDO TALDOR Homo sapiens (Human) 337 "carbohydrate metabolic process [GO:0005975]; fructose 6-phosphate metabolic process [GO:0006002]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; xylulose biosynthetic process [GO:0005999]" GO:0004801; GO:0005634; GO:0005737; GO:0005829; GO:0005975; GO:0005999; GO:0006002; GO:0006098; GO:0009052; GO:0048029; GO:0070062 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. 0 0 PF00923; P48148 CHOYP_RHO1.2.3 m.22647 sp RHO1_DROME 67.895 190 59 2 1 190 5 192 3.33E-91 267 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; P52594 CHOYP_LOC100371923.1.1 m.65326 sp AGFG1_HUMAN 35.14 572 247 18 12 541 5 494 3.33E-74 252 AGFG1_HUMAN reviewed Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein) (Nucleoporin-like protein RIP) (Rev-interacting protein) (Rev/Rex activation domain-binding protein) AGFG1 HRB RAB RIP Homo sapiens (Human) 562 acrosome assembly [GO:0001675]; intermediate filament organization [GO:0045109]; mRNA export from nucleus [GO:0006406]; multicellular organism development [GO:0007275]; spermatid nucleus differentiation [GO:0007289] GO:0001675; GO:0003677; GO:0003723; GO:0005096; GO:0005643; GO:0006406; GO:0007275; GO:0007289; GO:0016023; GO:0042995; GO:0043025; GO:0043231; GO:0045109; GO:0046872 0 0 0 PF01412; Q01528 CHOYP_HAAF.12.13 m.58589 sp HAAF_LIMPO 41.279 172 94 4 5 173 1 168 3.33E-38 131 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q5G872 CHOYP_BRAFLDRAFT_82713.1.1 m.40955 sp SCUB2_DANRE 35.652 115 68 4 60 171 651 762 3.33E-13 72 SCUB2_DANRE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein You)" scube2 you Danio rerio (Zebrafish) (Brachydanio rerio) 1010 blood circulation [GO:0008015]; muscle cell fate specification [GO:0042694]; muscle fiber development [GO:0048747]; muscle organ development [GO:0007517]; smoothened signaling pathway [GO:0007224]; somitogenesis [GO:0001756]; striated muscle cell differentiation [GO:0051146] GO:0001756; GO:0005509; GO:0005576; GO:0005615; GO:0007224; GO:0007517; GO:0008015; GO:0009897; GO:0009986; GO:0030141; GO:0042694; GO:0048747; GO:0051146 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q5QJC2 CHOYP_BRAFLDRAFT_215154.1.1 m.57396 sp DCR1C_CHICK 37.455 275 150 7 1 265 120 382 3.33E-45 173 DCR1C_CHICK reviewed Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (SNM1 homolog C) (chSNM1C) (SNM1-like protein) DCLRE1C SNM1C Gallus gallus (Chicken) 714 adaptive immune response [GO:0002250]; DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]; interstrand cross-link repair [GO:0036297]; protection from non-homologous end joining at telomere [GO:0031848] GO:0000784; GO:0002250; GO:0003684; GO:0004519; GO:0006303; GO:0006310; GO:0031848; GO:0035312; GO:0036297; GO:0070419 0 0 0 PF07522;PF12706; Q5XFW8 CHOYP_SEC13.1.1 m.20714 sp SEC13_RAT 71.935 310 81 3 60 363 2 311 3.33E-168 475 SEC13_RAT reviewed Protein SEC13 homolog (SEC13-like protein 1) Sec13 Sec13l1 Rattus norvegicus (Rat) 322 ER to Golgi vesicle-mediated transport [GO:0006888]; mRNA transport [GO:0051028]; protein transport [GO:0015031] GO:0005643; GO:0005789; GO:0005829; GO:0006888; GO:0012507; GO:0015031; GO:0031080; GO:0043234; GO:0051028 0 0 0 PF00400; Q7Z407 CHOYP_CSMD3.1.1 m.5047 sp CSMD3_HUMAN 28.446 341 206 12 3 325 2987 3307 3.33E-32 134 CSMD3_HUMAN reviewed CUB and sushi domain-containing protein 3 (CUB and sushi multiple domains protein 3) CSMD3 KIAA1894 Homo sapiens (Human) 3707 0 GO:0005886; GO:0016021 0 0 0 PF00431;PF00084; Q80TP3 CHOYP_RPL11.1.1 m.37676 sp UBR5_MOUSE 46.087 115 48 3 2 106 566 676 3.33E-18 82.4 UBR5_MOUSE reviewed "E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog)" Ubr5 Edd Edd1 Kiaa0896 Mus musculus (Mouse) 2792 "cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of protein import into nucleus, translocation [GO:0033160]; progesterone receptor signaling pathway [GO:0050847]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]" GO:0000209; GO:0003723; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0006974; GO:0008270; GO:0016020; GO:0016874; GO:0033160; GO:0034450; GO:0035413; GO:0042787; GO:0050847; GO:0090263; GO:1901315; GO:2000780 PATHWAY: Protein modification; protein ubiquitination. 0 cd14423; PF11547;PF00632;PF00658; Q80WT5 CHOYP_DSPP.6.8 m.47723 sp AFTIN_MOUSE 33.161 386 193 17 624 963 550 916 3.33E-29 129 AFTIN_MOUSE reviewed Aftiphilin Aftph Afth Mus musculus (Mouse) 931 intracellular transport [GO:0046907]; protein transport [GO:0015031] GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0015031; GO:0030121; GO:0030276; GO:0043231; GO:0046907 0 0 0 PF15045; Q80ZA4 CHOYP_BRAFLDRAFT_118430.1.2 m.29040 sp PKHL1_MOUSE 30.749 374 236 12 1 367 3813 4170 3.33E-38 157 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8BVM7 CHOYP_LOC100368365.1.2 m.18056 sp AL2SB_MOUSE 24.046 262 180 3 123 372 77 331 3.33E-16 82.8 AL2SB_MOUSE reviewed Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog Als2cr12 Mus musculus (Mouse) 383 0 GO:0001520; GO:0005737; GO:0035686; GO:0036126 0 0 0 0 Q96QE2 CHOYP_LOC100373277.1.2 m.5879 sp MYCT_HUMAN 45.25 579 292 10 3 573 65 626 3.33E-169 498 MYCT_HUMAN reviewed Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) 648 glucose import [GO:0046323]; hexose transmembrane transport [GO:0035428] GO:0005351; GO:0005355; GO:0005366; GO:0005886; GO:0005887; GO:0035428; GO:0046323 0 0 cd06174; PF00083; Q98892 CHOYP_LOC663721.1.1 m.38679 sp OBCAM_CHICK 32.743 339 180 14 9 343 10 304 3.33E-36 139 OBCAM_CHICK reviewed Opioid-binding protein/cell adhesion molecule homolog (Neurite inhibitor GP55-A) (OBCAM protein gamma isoform) OPCML Gallus gallus (Chicken) 337 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225 0 0 0 PF07679; Q99NE9 CHOYP_PBX4.1.2 m.12890 sp PBX4_MOUSE 29.677 155 86 4 399 532 189 341 3.33E-10 65.5 PBX4_MOUSE reviewed Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4) Pbx4 Mus musculus (Mouse) 378 "positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0001741; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0043565; GO:0045893 0 0 0 PF00046;PF03792; Q9NVH0 CHOYP_LOC100553135.1.1 m.51640 sp EXD2_HUMAN 38.762 614 318 10 16 590 13 607 3.33E-140 423 EXD2_HUMAN reviewed Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (Exonuclease 3'-5' domain-like-containing protein 2) EXD2 C14orf114 EXDL2 Homo sapiens (Human) 621 DNA double-strand break processing [GO:0000729]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; nucleic acid phosphodiester bond hydrolysis [GO:0090305] GO:0000724; GO:0000729; GO:0003676; GO:0005634; GO:0005737; GO:0006302; GO:0008310; GO:0008408; GO:0008852; GO:0090305 0 0 0 PF01612; Q9UKZ1 CHOYP_LOC100561785.1.1 m.10324 sp CNO11_HUMAN 69.524 315 84 3 39 350 196 501 3.33E-155 449 CNO11_HUMAN reviewed CCR4-NOT transcription complex subunit 11 CNOT11 C2orf29 C40 Homo sapiens (Human) 510 "cell proliferation [GO:0008283]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; gene silencing by RNA [GO:0031047]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000289; GO:0005634; GO:0005829; GO:0006351; GO:0006355; GO:0006417; GO:0006977; GO:0008283; GO:0030014; GO:0031047 0 0 0 PF10155; A2RT91 CHOYP_BRAFLDRAFT_118772.1.1 m.59465 sp ANKAR_MOUSE 30.667 750 501 12 6 750 613 1348 3.34E-106 361 ANKAR_MOUSE reviewed Ankyrin and armadillo repeat-containing protein Ankar Mus musculus (Mouse) 1465 0 GO:0005634; GO:0005737; GO:0016021 0 0 0 PF00514; A6QPC8 CHOYP_LOC100565039.2.2 m.16852 sp EID3_BOVIN 35.758 330 194 6 16 330 49 375 3.34E-58 196 EID3_BOVIN reviewed EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) EID3 Bos taurus (Bovine) 379 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005737; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0030915 0 0 0 PF15412;PF08743; B1H116 CHOYP_UCK2.1.1 m.6328 sp UCK2_XENTR 64.754 244 77 1 44 278 18 261 3.34E-115 334 UCK2_XENTR reviewed Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Uridine monophosphokinase 2) uck2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 261 CMP salvage [GO:0006238]; CTP salvage [GO:0044211]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206] GO:0004849; GO:0005524; GO:0005829; GO:0006206; GO:0006238; GO:0043097; GO:0044206; GO:0044211 PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. 0 0 PF00485; B1MTJ4 CHOYP_SETD3.1.1 m.42582 sp SETD3_PLEMO 50 498 231 7 1 491 1 487 3.34E-173 503 SETD3_PLEMO reviewed Histone-lysine N-methyltransferase setd3 (EC 2.1.1.43) (SET domain-containing protein 3) SETD3 Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch) 595 "histone H3-K36 methylation [GO:0010452]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; peptidyl-lysine trimethylation [GO:0018023]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0006351; GO:0010452; GO:0018023; GO:0018026; GO:0018027; GO:0045893; GO:0046975 0 0 0 PF09273;PF00856; C5DJG1 CHOYP_LOC663019.1.1 m.9872 sp RTC5_LACTC 28.736 174 84 8 331 474 386 549 3.34E-06 53.1 RTC5_LACTC reviewed Restriction of telomere capping protein 5 RTC5 KLTH0F16126g Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans) 554 0 GO:0005634; GO:0005829 0 0 0 PF07534; D2GXS7 CHOYP_LOC100369333.32.32 m.65029 sp TRIM2_AILME 22.374 219 156 5 317 523 492 708 3.34E-07 56.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O08762 CHOYP_BRAFLDRAFT_68915.2.7 m.3908 sp NETR_MOUSE 40.469 341 182 5 783 1111 166 497 3.34E-70 255 NETR_MOUSE reviewed Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12) Prss12 Bssp3 Mus musculus (Mouse) 761 exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202 0 0 cd00190; PF00051;PF00530;PF00089; O43345 CHOYP_BRAFLDRAFT_66688.2.2 m.10883 sp ZN208_HUMAN 20.535 935 611 32 565 1457 230 1074 3.34E-18 95.9 ZN208_HUMAN reviewed Zinc finger protein 208 (Zinc finger protein 91-like) ZNF208 ZNF91L Homo sapiens (Human) 1280 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 cd07765; PF01352;PF13912; P10982 CHOYP_ACT5.2.3 m.36677 sp ACT1_ABSGL 68.862 167 10 1 3 169 4 128 3.34E-78 232 ACT1_ABSGL reviewed Actin-1 (Fragment) ACT1 Absidia glauca (Pin mould) 140 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P24668 CHOYP_LOC100863962.1.2 m.24668 sp MPRD_MOUSE 28.313 166 108 2 98 252 81 246 3.34E-14 73.9 MPRD_MOUSE reviewed Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46) M6pr 46mpr Mus musculus (Mouse) 278 intracellular protein transport [GO:0006886]; secretion of lysosomal enzymes [GO:0033299] GO:0005537; GO:0005765; GO:0005768; GO:0005770; GO:0005802; GO:0006886; GO:0015578; GO:0016020; GO:0016021; GO:0033299; GO:0048471 0 0 0 PF02157; P35295 CHOYP_LOC583583.1.1 m.28867 sp RAB20_MOUSE 37.339 233 115 4 7 209 2 233 3.34E-43 147 RAB20_MOUSE reviewed Ras-related protein Rab-20 Rab20 Mus musculus (Mouse) 233 phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; protein transport [GO:0015031]; regulation of autophagosome assembly [GO:2000785]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0030670; GO:0043231; GO:0045335; GO:0090383; GO:0090385; GO:2000785 0 0 0 PF00071; P62972 CHOYP_UBIQP.7.13 m.23231 sp UBIQP_XENLA 76.974 152 0 1 1 117 16 167 3.34E-73 220 UBIQP_XENLA reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Xenopus laevis (African clawed frog) 167 0 GO:0005634; GO:0005737 0 0 0 PF00240; Q01279 CHOYP_EGFR.2.3 m.61781 sp EGFR_MOUSE 41.7 247 132 4 38 284 31 265 3.34E-47 172 EGFR_MOUSE reviewed Epidermal growth factor receptor (EC 2.7.10.1) Egfr Mus musculus (Mouse) 1210 cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amino acid stimulus [GO:0071230]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cerebral cortex cell migration [GO:0021795]; digestive tract morphogenesis [GO:0048546]; embryonic placenta development [GO:0001892]; epidermal growth factor receptor signaling pathway [GO:0007173]; epidermis development [GO:0008544]; eyelid development in camera-type eye [GO:0061029]; hair follicle development [GO:0001942]; learning or memory [GO:0007611]; morphogenesis of an epithelial fold [GO:0060571]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phosphorylation [GO:0042327]; positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777]; regulation of cell proliferation [GO:0042127]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to UV-A [GO:0070141]; salivary gland morphogenesis [GO:0007435]; signal transduction [GO:0007165]; single organismal cell-cell adhesion [GO:0016337] GO:0000139; GO:0000902; GO:0001892; GO:0001934; GO:0001942; GO:0003682; GO:0004713; GO:0004716; GO:0004871; GO:0004888; GO:0005006; GO:0005524; GO:0005622; GO:0005634; GO:0005737; GO:0005768; GO:0005789; GO:0005886; GO:0005925; GO:0007165; GO:0007166; GO:0007173; GO:0007435; GO:0007611; GO:0008283; GO:0008284; GO:0008544; GO:0009986; GO:0010008; GO:0016020; GO:0016021; GO:0016301; GO:0016323; GO:0016337; GO:0019899; GO:0019903; GO:0021795; GO:0030139; GO:0030235; GO:0030307; GO:0030335; GO:0031625; GO:0031659; GO:0031901; GO:0031965; GO:0035413; GO:0042127; GO:0042177; GO:0042327; GO:0042802; GO:0043066; GO:0043235; GO:0043406; GO:0045121; GO:0045429; GO:0045739; GO:0045740; GO:0045944; GO:0046777; GO:0046982; GO:0048146; GO:0048408; GO:0048471; GO:0048546; GO:0050679; GO:0050730; GO:0050999; GO:0051015; GO:0051897; GO:0060571; GO:0061029; GO:0070141; GO:0070374; GO:0071230; GO:0071364; GO:0071392; GO:0097489; GO:1903800 0 0 0 PF00757;PF14843;PF07714;PF01030; Q24157 CHOYP_ISCW_ISCW013734.1.1 m.31848 sp BRN_DROME 38.211 246 125 7 150 377 80 316 3.34E-44 159 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q28GD4 CHOYP_LOC100533384.5.5 m.59082 sp ELAV2_XENTR 43.333 330 161 5 2 328 63 369 3.34E-91 280 ELAV2_XENTR reviewed ELAV-like protein 2 (Protein ElrB) elavl2 elrB TEgg126j06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 375 multicellular organism development [GO:0007275] GO:0000166; GO:0003723; GO:0005938; GO:0007275; GO:0030529 0 0 0 PF00076; Q2KIT4 CHOYP_LOC752244.1.2 m.18670 sp DNJB4_BOVIN 42.958 142 58 2 2 137 101 225 3.34E-22 93.2 DNJB4_BOVIN reviewed DnaJ homolog subfamily B member 4 DNAJB4 Bos taurus (Bovine) 337 protein folding [GO:0006457] GO:0005654; GO:0005829; GO:0005886; GO:0006457; GO:0070062 0 0 cd06257; PF00226;PF01556; Q3SZZ2 CHOYP_NEMVEDRAFT_V1G198897.2.6 m.4751 sp XBP1_BOVIN 49.593 123 55 2 5 120 14 136 3.34E-28 106 XBP1_BOVIN reviewed "X-box-binding protein 1 (XBP-1) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" XBP1 Bos taurus (Bovine) 261 adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein destabilization [GO:0031648]; regulation of autophagy [GO:0010506]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription from RNA polymerase II promoter [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000122; GO:0000977; GO:0000981; GO:0001047; GO:0001158; GO:0001525; GO:0001889; GO:0001934; GO:0001935; GO:0002639; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006366; GO:0006511; GO:0006990; GO:0007517; GO:0010506; GO:0010508; GO:0010832; GO:0014065; GO:0016049; GO:0030176; GO:0031017; GO:0031062; GO:0031490; GO:0031648; GO:0031670; GO:0032008; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035924; GO:0042149; GO:0042632; GO:0042993; GO:0043066; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051024; GO:0055089; GO:0055092; GO:0060612; GO:0060691; GO:0070059; GO:0071222; GO:0071230; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:1900100; GO:1900102; GO:1900103; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1990418; GO:2000347; GO:2000353; GO:2000778 0 0 0 PF07716; Q56R14 CHOYP_BRAFLDRAFT_69765.22.23 m.61001 sp TRI33_XENLA 25.446 224 126 7 22 232 185 380 3.34E-06 53.9 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5R1S9 CHOYP_CAF1B.1.4 m.627 sp CAF1B_CHICK 58.549 193 77 2 1 190 1 193 3.34E-76 241 CAF1B_CHICK reviewed Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) CHAF1B CAF1P60 RCJMB04_5h12 Gallus gallus (Chicken) 566 "cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006260; GO:0006281; GO:0006334; GO:0006351; GO:0006355; GO:0007049; GO:0031497; GO:0033186; GO:0042393 0 0 0 PF15512;PF00400; Q5R611 CHOYP_LOC100377759.14.15 m.63307 sp HRSL3_PONAB 32.934 167 105 2 11 176 2 162 3.34E-23 93.2 HRSL3_PONAB reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) PLA2G16 HRASLS3 HREV107 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 162 lipid catabolic process [GO:0016042] GO:0004623; GO:0008970; GO:0016021; GO:0016042; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; Q5RJ80 CHOYP_C1QL2.1.32 m.470 sp CAPR2_DANRE 35.294 102 62 3 314 414 813 911 3.34E-09 62.8 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5ZM55 CHOYP_LOC100877516.1.1 m.37232 sp FEM1B_CHICK 58.311 367 152 1 27 392 8 374 3.34E-152 446 FEM1B_CHICK reviewed Protein fem-1 homolog B (FEM1b) (FEM1-beta) FEM1B RCJMB04_3b14 Gallus gallus (Chicken) 627 apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001] GO:0005634; GO:0005737; GO:0006915; GO:0016567; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00023;PF12796; Q63312 CHOYP_PHLB1.1.1 m.43053 sp PHLB1_RAT 33.982 668 327 11 1066 1669 213 830 3.34E-91 319 PHLB1_RAT reviewed Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha) (Fragment) Phldb1 Ll5 Rattus norvegicus (Rat) 831 0 0 0 0 0 PF00169; Q65ZX2 CHOYP_contig_018054 m.21137 sp IF2_BORBP 33.051 118 77 2 100 215 69 186 3.34E-06 53.1 IF2_BORBP reviewed Translation initiation factor IF-2 infB BG0827 Borreliella bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi) (Borrelia bavariensis) 883 0 GO:0003743; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF11987;PF04760; Q6GQN0 CHOYP_MEST.2.2 m.55065 sp CEP41_DANRE 39.773 352 162 8 15 322 13 358 3.34E-75 239 CEP41_DANRE reviewed Centrosomal protein of 41 kDa (Cep41) (Testis-specific gene A14 protein) cep41 tsga14 zgc:91859 Danio rerio (Zebrafish) (Brachydanio rerio) 374 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; protein polyglutamylation [GO:0018095]; protein transport [GO:0015031]; single organismal cell-cell adhesion [GO:0016337] GO:0005814; GO:0005886; GO:0005911; GO:0009986; GO:0015031; GO:0016337; GO:0018095; GO:0035082; GO:0036064; GO:0042384; GO:0070740; GO:0072372 0 0 0 PF00581; Q6IV57 CHOYP_RN141.1.1 m.66242 sp RN141_RAT 38.095 210 119 4 47 251 19 222 3.34E-49 164 RN141_RAT reviewed RING finger protein 141 Rnf141 Rattus norvegicus (Rat) 230 "protein autoubiquitination [GO:0051865]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0004842; GO:0006355; GO:0008270; GO:0016020; GO:0051865 0 0 0 0 Q6PFY8 CHOYP_LOC100378898.3.10 m.32681 sp TRI45_MOUSE 29.412 204 127 6 8 205 129 321 3.34E-12 72.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7ZXX1 CHOYP_CADM4.1.1 m.60661 sp CADM3_XENLA 30.508 236 128 10 126 360 99 299 3.34E-14 77.8 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q80TA9 CHOYP_ELL.1.1 m.21543 sp EPG5_MOUSE 34.541 414 252 7 1 401 648 1055 3.34E-77 265 EPG5_MOUSE reviewed Ectopic P granules protein 5 homolog Epg5 Kiaa1632 Mus musculus (Mouse) 2572 autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; endocytic recycling [GO:0032456] GO:0005737; GO:0006914; GO:0032456; GO:0097352 0 0 0 0 Q8ITC7 CHOYP_LOC100878560.1.1 m.27842 sp CAPAR_DROME 35.035 431 252 10 1 420 12 425 3.34E-70 234 CAPAR_DROME reviewed Neuropeptides capa receptor (Cap2b receptor) (Capability receptor) CapaR CG14575 Drosophila melanogaster (Fruit fly) 477 body fluid secretion [GO:0007589]; cellular response to desiccation [GO:0071465]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of calcium ion transport [GO:0051928] GO:0001607; GO:0007186; GO:0007218; GO:0007589; GO:0008188; GO:0016021; GO:0016323; GO:0051928; GO:0071465 0 0 0 PF00001; Q8IZJ3 CHOYP_TRIADDRAFT_55768.1.2 m.4473 sp CPMD8_HUMAN 30.532 357 203 5 1 316 1240 1592 3.34E-49 179 CPMD8_HUMAN reviewed C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) 1885 0 GO:0004867; GO:0005615; GO:0005886 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF07648;PF12248;PF10569; Q8K4G1 CHOYP_LOC100637503.1.1 m.47370 sp LTBP4_MOUSE 36.147 545 257 28 25 500 610 1132 3.34E-65 237 LTBP4_MOUSE reviewed Latent-transforming growth factor beta-binding protein 4 (LTBP-4) Ltbp4 Mus musculus (Mouse) 1666 hormone secretion [GO:0046879]; regulation of proteolysis [GO:0030162]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005509; GO:0005578; GO:0005615; GO:0007179; GO:0030162; GO:0031012; GO:0046879; GO:0050431; GO:0070062 0 0 0 PF07645;PF00683; Q8N695 CHOYP_SC5A8.2.2 m.28590 sp SC5A8_HUMAN 39.016 610 344 13 1 609 26 608 3.34E-133 406 SC5A8_HUMAN reviewed Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) 610 apoptotic process [GO:0006915]; ion transport [GO:0006811]; sodium ion transport [GO:0006814] GO:0005886; GO:0005887; GO:0006811; GO:0006814; GO:0006915; GO:0008028; GO:0015293; GO:0016324; GO:0022803; GO:0070062 0 0 0 PF00474; Q8WYH8 CHOYP_BRAFLDRAFT_133135.1.1 m.18788 sp ING5_HUMAN 63.306 248 77 2 180 422 1 239 3.34E-108 322 ING5_HUMAN reviewed Inhibitor of growth protein 5 (p28ING5) ING5 Homo sapiens (Human) 240 "chromatin modification [GO:0016568]; DNA replication [GO:0006260]; histone H3 acetylation [GO:0043966]; negative regulation of cell proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of transcription, DNA-templated [GO:0045893]; protein acetylation [GO:0006473]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0005634; GO:0005654; GO:0006260; GO:0006351; GO:0006473; GO:0008270; GO:0008285; GO:0016568; GO:0035064; GO:0043065; GO:0043966; GO:0045893; GO:0045926; GO:0070776; GO:1901796; GO:2001235 0 0 0 PF12998; Q95ND5 CHOYP_TSP_11696.1.1 m.60698 sp CASP3_PIG 22.796 329 153 10 83 408 45 275 3.34E-16 81.6 CASP3_PIG reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Sus scrofa (Pig) 277 erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182] GO:0005634; GO:0005737; GO:0030182; GO:0030216; GO:0030218; GO:0097194; GO:0097200 0 0 0 0 Q99M80 CHOYP_PTPRK.6.20 m.6291 sp PTPRT_MOUSE 31.054 702 430 14 612 1264 757 1453 3.34E-101 356 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_92727.14.17 m.53342 sp TRIM2_MOUSE 26.633 199 119 8 113 301 516 697 3.34E-06 52 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9LQV2 CHOYP_BRAFLDRAFT_99723.1.9 m.3304 sp RDR1_ARATH 46.098 410 208 7 16 420 531 932 3.34E-106 342 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; Q9V8M2 CHOYP_LOC100376649.4.4 m.57217 sp C12B2_DROME 31.674 442 265 15 6 424 101 528 3.34E-58 202 C12B2_DROME reviewed "Probable cytochrome P450 12b2, mitochondrial (EC 1.14.-.-) (CYPXIIB2)" Cyp12b2 CG15077 Drosophila melanogaster (Fruit fly) 535 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037; GO:0031966 0 0 0 PF00067; Q9WVH6 CHOYP_BRAFLDRAFT_108085.3.3 m.64658 sp ANGP4_MOUSE 47.059 51 26 1 184 234 293 342 3.34E-10 62.8 ANGP4_MOUSE reviewed Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) 509 angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; endoderm development [GO:0007492]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; Tie signaling pathway [GO:0048014] GO:0001525; GO:0005172; GO:0005615; GO:0007219; GO:0007492; GO:0010595; GO:0016525; GO:0030297; GO:0030971; GO:0043066; GO:0043536; GO:0043537; GO:0045766; GO:0048014; GO:0050731; GO:0071456 0 0 0 PF00147; Q9XZ71 CHOYP_TNNT.1.1 m.26279 sp TNNT_PERAM 40.784 255 127 7 60 310 48 282 3.34E-30 121 TNNT_PERAM reviewed Troponin T (TnT) TNT Periplaneta americana (American cockroach) (Blatta americana) 384 regulation of muscle contraction [GO:0006937] GO:0005861; GO:0006937 0 0 0 PF00992; Q9Y3B2 CHOYP_NEMVEDRAFT_V1G238196.2.2 m.66719 sp EXOS1_HUMAN 58.333 168 67 3 3 168 1 167 3.34E-60 189 EXOS1_HUMAN reviewed Exosome complex component CSL4 (Exosome component 1) EXOSC1 CSL4 CGI-108 Homo sapiens (Human) 195 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; regulation of mRNA stability [GO:0043488]; rRNA processing [GO:0006364] GO:0000176; GO:0000178; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0043488; GO:0043928 0 0 0 PF14382;PF10447; A4II09 CHOYP_BRAFLDRAFT_75590.1.1 m.29551 sp EIF3A_XENTR 57.282 103 44 0 1 103 581 683 3.35E-22 93.2 EIF3A_XENTR reviewed Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) eif3a eif3s10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1391 formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446] GO:0001731; GO:0001732; GO:0003743; GO:0005852; GO:0006446; GO:0016282; GO:0033290 0 0 0 PF01399; B3EWZ6 CHOYP_LOC100207753.2.3 m.5661 sp MLRP2_ACRMI 31.641 591 314 20 378 954 534 1048 3.35E-67 250 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O94889 CHOYP_KLHDB.4.5 m.48810 sp KLH18_HUMAN 22.93 628 388 18 508 1126 9 549 3.35E-36 149 KLH18_HUMAN reviewed Kelch-like protein 18 KLHL18 KIAA0795 OK/SW-cl.74 Homo sapiens (Human) 574 protein ubiquitination [GO:0016567] GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; P14381 CHOYP_LOC100371228.1.4 m.6670 sp YTX2_XENLA 27.809 356 241 8 22 370 35 381 3.35E-34 137 YTX2_XENLA reviewed Transposon TX1 uncharacterized 149 kDa protein (ORF 2) 0 Xenopus laevis (African clawed frog) 1308 0 0 0 0 0 PF03372;PF00078; P16157 CHOYP_TVAG_287350.1.5 m.2078 sp ANK1_HUMAN 28.049 328 186 7 21 320 94 399 3.35E-24 109 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P21757 CHOYP_BRAFLDRAFT_124580.1.1 m.34489 sp MSRE_HUMAN 46.154 91 48 1 31 121 340 429 3.35E-20 87.4 MSRE_HUMAN reviewed Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204) MSR1 SCARA1 Homo sapiens (Human) 451 cellular response to organic cyclic compound [GO:0071407]; cholesterol transport [GO:0030301]; lipoprotein transport [GO:0042953]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005581; GO:0005829; GO:0005886; GO:0005887; GO:0006898; GO:0010744; GO:0010886; GO:0030169; GO:0030301; GO:0030666; GO:0034362; GO:0034381; GO:0042953; GO:0071407 0 0 0 PF01391;PF03523;PF00530; P59510 CHOYP_ATS20.1.2 m.40046 sp ATS20_HUMAN 43.005 193 100 7 162 350 1655 1841 3.35E-37 145 ATS20_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAM-TS 20) (ADAM-TS20) (ADAMTS-20) (EC 3.4.24.-) ADAMTS20 Homo sapiens (Human) 1910 extracellular matrix organization [GO:0030198]; negative regulation of apoptotic process [GO:0043066]; positive regulation of melanocyte differentiation [GO:0045636]; positive regulation of signal transduction [GO:0009967] GO:0004222; GO:0005578; GO:0005615; GO:0008270; GO:0009967; GO:0030198; GO:0043066; GO:0045636 0 0 0 PF05986;PF08685;PF01562;PF01421;PF00090; P62501 CHOYP_T22D1.1.1 m.31279 sp T22D1_RAT 90.164 61 6 0 255 315 44 104 3.35E-30 115 T22D1_RAT reviewed TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Tsc22d1 Tgfb1i4 Tsc22 Rattus norvegicus (Rat) 143 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351 0 0 0 PF01166; Q0V8E7 CHOYP_LOC100893754.1.1 m.53870 sp STRA6_BOVIN 22.648 627 424 15 52 643 67 667 3.35E-30 130 STRA6_BOVIN reviewed Stimulated by retinoic acid gene 6 protein homolog STRA6 Bos taurus (Bovine) 668 0 GO:0004872; GO:0005886; GO:0016021; GO:0051183 0 0 0 0 Q13263 CHOYP_LOC100375148.1.2 m.20681 sp TIF1B_HUMAN 32.432 111 67 5 7 111 146 254 3.35E-06 49.3 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q15811 CHOYP_DSIM_GD21654.1.1 m.63444 sp ITSN1_HUMAN 24.62 329 204 12 457 770 920 1219 3.35E-14 82 ITSN1_HUMAN reviewed Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17) ITSN1 ITSN SH3D1A Homo sapiens (Human) 1721 ephrin receptor signaling pathway [GO:0048013]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle endocytosis [GO:0048488] GO:0005085; GO:0005089; GO:0005509; GO:0005829; GO:0005886; GO:0005905; GO:0007264; GO:0019209; GO:0030027; GO:0030054; GO:0030139; GO:0032947; GO:0035023; GO:0043005; GO:0043065; GO:0043524; GO:0045202; GO:0048013; GO:0048488; GO:0051056; GO:0051897; GO:0070064 0 0 0 PF00168;PF12763;PF16652;PF00621;PF00018;PF14604; Q2KHZ8 CHOYP_GLCM.1.3 m.5253 sp GLCM_BOVIN 47.262 493 253 4 25 512 40 530 3.35E-176 509 GLCM_BOVIN reviewed Glucosylceramidase (EC 3.2.1.45) (Acid beta-glucosidase) (Beta-glucocerebrosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) GBA Bos taurus (Bovine) 536 carbohydrate metabolic process [GO:0005975]; sphingolipid metabolic process [GO:0006665] GO:0004348; GO:0005765; GO:0005975; GO:0006665 0 0 0 PF02055;PF17189; Q3ZBH3 CHOYP_CD37.1.1 m.13774 sp CD151_BOVIN 24.436 266 169 4 9 274 16 249 3.35E-16 80.5 CD151_BOVIN reviewed CD151 antigen (CD antigen CD151) CD151 Bos taurus (Bovine) 253 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q5PPZ5 CHOYP_BRAFLDRAFT_285391.2.2 m.41165 sp BIN3_XENLA 35.294 255 158 3 46 297 1 251 3.35E-55 182 BIN3_XENLA reviewed Bridging integrator 3 homolog bin3 Xenopus laevis (African clawed frog) 252 barrier septum assembly [GO:0000917] GO:0000917; GO:0005737; GO:0005856 0 0 0 PF03114; Q5XGP7 CHOYP_SKAP1.1.1 m.5859 sp SKA2A_XENLA 38.136 118 65 2 52 162 99 215 3.35E-17 81.6 SKA2A_XENLA reviewed Src kinase-associated phosphoprotein 2-A skap2-a Xenopus laevis (African clawed frog) 330 B cell activation [GO:0042113] GO:0005737; GO:0042113 0 0 0 PF00169;PF00018; Q5ZMD4 CHOYP_BRAFLDRAFT_88217.9.14 m.45940 sp TRI59_CHICK 44.444 90 41 4 11 97 2 85 3.35E-11 67.4 TRI59_CHICK reviewed Tripartite motif-containing protein 59 TRIM59 RCJMB04_2h17 Gallus gallus (Chicken) 408 cilium assembly [GO:0042384] GO:0005783; GO:0005789; GO:0005813; GO:0005929; GO:0008270; GO:0016021; GO:0030992; GO:0042384 0 0 0 PF00643;PF13445; Q60648 CHOYP_GM2A.1.3 m.4103 sp SAP3_MOUSE 30.675 163 105 5 311 471 28 184 3.35E-21 94.4 SAP3_MOUSE reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) 193 ganglioside catabolic process [GO:0006689]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; neurological system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; positive regulation of hydrolase activity [GO:0051345] GO:0004563; GO:0005319; GO:0005739; GO:0005764; GO:0005889; GO:0006689; GO:0007611; GO:0008047; GO:0009313; GO:0009898; GO:0016004; GO:0019915; GO:0032428; GO:0045179; GO:0050877; GO:0050885; GO:0051345; GO:0070062 0 0 0 PF02221; Q68CZ1 CHOYP_BRAFLDRAFT_221898.2.2 m.32473 sp FTM_HUMAN 37.705 183 103 3 4 177 1130 1310 3.35E-30 119 FTM_HUMAN reviewed Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein) RPGRIP1L FTM KIAA1005 NPHP8 Homo sapiens (Human) 1315 camera-type eye development [GO:0043010]; cerebellum development [GO:0021549]; cilium assembly [GO:0042384]; cochlea development [GO:0090102]; corpus callosum development [GO:0022038]; determination of left/right symmetry [GO:0007368]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of planar polarity [GO:0001736]; establishment or maintenance of cell polarity [GO:0007163]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lateral ventricle development [GO:0021670]; liver development [GO:0001889]; negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744]; neural tube patterning [GO:0021532]; nose development [GO:0043584]; olfactory bulb development [GO:0021772]; pericardium development [GO:0060039]; regulation of smoothened signaling pathway [GO:0008589] GO:0001701; GO:0001736; GO:0001822; GO:0001889; GO:0005737; GO:0005813; GO:0005829; GO:0005911; GO:0005923; GO:0005929; GO:0005930; GO:0007163; GO:0007368; GO:0008589; GO:0021532; GO:0021549; GO:0021670; GO:0021772; GO:0022038; GO:0031870; GO:0035115; GO:0035116; GO:0035869; GO:0036064; GO:0042384; GO:0043010; GO:0043584; GO:0045744; GO:0060039; GO:0090102 0 0 0 PF00168;PF11618; Q6P158 CHOYP_DHX57.2.2 m.45702 sp DHX57_HUMAN 55.137 292 119 3 26 306 486 776 3.35E-101 327 DHX57_HUMAN reviewed Putative ATP-dependent RNA helicase DHX57 (EC 3.6.4.13) (DEAH box protein 57) DHX57 Homo sapiens (Human) 1386 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005739; GO:0006396; GO:0044822; GO:0046872 0 0 0 PF00270;PF04408;PF00271;PF07717;PF05773;PF00642; Q8R4S0 CHOYP_RALA.4.4 m.26414 sp PP14C_MOUSE 31.111 90 55 3 69 158 71 153 3.35E-06 47.8 PP14C_MOUSE reviewed Protein phosphatase 1 regulatory subunit 14C (Kinase-enhanced PP1 inhibitor) (PKC-potentiated PP1 inhibitory protein) Ppp1r14c Kepi Mus musculus (Mouse) 164 regulation of phosphorylation [GO:0042325]; regulation of protein dephosphorylation [GO:0035304]; signal transduction [GO:0007165] GO:0004865; GO:0005737; GO:0007165; GO:0012505; GO:0016020; GO:0035304; GO:0042325 0 0 0 PF05361; Q8WQI5 CHOYP_RS8.13.14 m.60906 sp RS8_SPOFR 70.109 184 53 1 1 184 1 182 3.35E-89 263 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q923S9 CHOYP_LOC659383.1.2 m.24127 sp RAB30_MOUSE 66.667 177 59 0 1 177 3 179 3.35E-87 258 RAB30_MOUSE reviewed Ras-related protein Rab-30 Rab30 Rsb30 Mus musculus (Mouse) 203 Golgi organization [GO:0007030]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0005801; GO:0005802; GO:0007030; GO:0007264; GO:0016020; GO:0031985 0 0 0 PF00071; Q923S9 CHOYP_LOC659383.2.2 m.60368 sp RAB30_MOUSE 66.667 177 59 0 1 177 3 179 3.35E-87 258 RAB30_MOUSE reviewed Ras-related protein Rab-30 Rab30 Rsb30 Mus musculus (Mouse) 203 Golgi organization [GO:0007030]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0005801; GO:0005802; GO:0007030; GO:0007264; GO:0016020; GO:0031985 0 0 0 PF00071; Q99JF5 CHOYP_MVD1.1.1 m.28700 sp MVD1_MOUSE 54.04 396 172 7 5 393 6 398 3.35E-139 405 MVD1_MOUSE reviewed Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) Mvd Mus musculus (Mouse) 401 "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]; isoprenoid biosynthetic process [GO:0008299]; positive regulation of cell proliferation [GO:0008284]" GO:0004163; GO:0005524; GO:0005829; GO:0006695; GO:0008284; GO:0008299; GO:0019287; GO:0030544; GO:0042803 PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. 0 0 PF00288; Q9CRB9 CHOYP_LOC100368194.1.1 m.59989 sp MIC19_MOUSE 30.769 143 88 2 29 163 88 227 3.35E-14 70.5 MIC19_MOUSE reviewed MICOS complex subunit Mic19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3) Chchd3 Mic19 Mus musculus (Mouse) 227 "cristae formation [GO:0042407]; inner mitochondrial membrane organization [GO:0007007]; mitochondrial fusion [GO:0008053]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001227; GO:0005634; GO:0005737; GO:0005739; GO:0005743; GO:0006351; GO:0007007; GO:0008053; GO:0019902; GO:0032947; GO:0042407; GO:0061617; GO:0070062 0 0 0 PF05300; Q9DDT2 CHOYP_LOC101078145.1.1 m.54616 sp BCAP_CHICK 26.19 210 141 4 186 390 196 396 3.35E-13 75.9 BCAP_CHICK reviewed Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Gallus gallus (Chicken) 800 cellular response to insulin stimulus [GO:0032869]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; regulation of inflammatory response [GO:0050727]; regulation of kinase activity [GO:0043549]; regulation of phosphorylation [GO:0042325]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; TOR signaling [GO:0031929] GO:0005829; GO:0005886; GO:0014068; GO:0016020; GO:0031929; GO:0032869; GO:0034122; GO:0034123; GO:0034134; GO:0034142; GO:0034154; GO:0034162; GO:0036312; GO:0042325; GO:0043549; GO:0050727 0 0 0 PF14545; Q9ERR2 CHOYP_BRAFLDRAFT_132957.1.1 m.51288 sp COMD5_RAT 47.368 152 80 0 15 166 73 224 3.35E-47 155 COMD5_RAT reviewed COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG) Commd5 Rattus norvegicus (Rat) 224 "cell cycle arrest [GO:0007050]; positive regulation of cell growth [GO:0030307]; positive regulation of epithelial cell differentiation [GO:0030858]; proximal tubule morphogenesis [GO:0072158]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007050; GO:0030307; GO:0030858; GO:0072158 0 0 0 PF07258; Q9GZZ6 CHOYP_ACHAA.1.2 m.58157 sp ACH10_HUMAN 26.34 429 279 10 151 557 34 447 3.35E-38 149 ACH10_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 NACHRA10 Homo sapiens (Human) 450 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell proliferation [GO:0042127]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005102; GO:0005262; GO:0005892; GO:0007165; GO:0007204; GO:0007271; GO:0016020; GO:0030054; GO:0030424; GO:0042127; GO:0042166; GO:0042472; GO:0043204; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; Q9HCE3 CHOYP_LOC100378229.2.2 m.24904 sp ZN532_HUMAN 27.85 535 283 17 41 546 839 1299 3.35E-38 154 ZN532_HUMAN reviewed Zinc finger protein 532 ZNF532 KIAA1629 Homo sapiens (Human) 1301 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0044212; GO:0046872 0 0 0 PF16622;PF13912; Q9WTY1 CHOYP_LOC100373107.1.1 m.505 sp PDCD7_MOUSE 39.45 218 132 0 346 563 263 480 3.35E-37 147 PDCD7_MOUSE reviewed Programmed cell death protein 7 (ES18) Pdcd7 Mus musculus (Mouse) 482 apoptotic process [GO:0006915]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of T cell apoptotic process [GO:0070234]; response to glucocorticoid [GO:0051384] GO:0005689; GO:0006915; GO:0051384; GO:0070234; GO:2001235 0 0 0 PF16021; A0A0R4IBK5 CHOYP_RN213.8.13 m.52889 sp R213A_DANRE 29.268 1312 821 35 7 1273 3855 5104 3.36E-147 498 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A2VE56 CHOYP_P20L1.1.1 m.65439 sp P20L1_BOVIN 45.455 143 74 1 96 234 1 143 3.36E-37 146 P20L1_BOVIN reviewed PHD finger protein 20-like protein 1 PHF20L1 Bos taurus (Bovine) 316 0 0 0 0 0 PF12618;PF02820; D2GXS7 CHOYP_BRAFLDRAFT_102380.2.11 m.24162 sp TRIM2_AILME 30.252 119 71 4 217 326 616 731 3.36E-06 52.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_MEG10.36.91 m.39562 sp MEGF6_HUMAN 34.649 228 135 8 2 228 782 996 3.36E-27 112 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O97237 CHOYP_SRRM2.1.1 m.10689 sp YGCC1_PLAF7 20 135 108 0 459 593 230 364 3.36E-08 62 YGCC1_PLAF7 reviewed GRIP and coiled-coil domain-containing protein PFC0235w PFC0235w Plasmodium falciparum (isolate 3D7) 1139 protein targeting to Golgi [GO:0000042] GO:0000042; GO:0005622 0 0 0 0 P02637 CHOYP_SCP.10.12 m.62955 sp SCP_MIZYE 32.961 179 109 6 19 196 2 170 3.36E-24 97.1 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P09815 CHOYP_contig_000895 m.924 sp ICEN_PSEFL 37.407 270 151 3 72 324 273 541 3.36E-22 101 ICEN_PSEFL reviewed Ice nucleation protein inaW Pseudomonas fluorescens 1210 0 GO:0009279; GO:0050825 0 0 0 PF00818; P10247 CHOYP_YMV2.1.1 m.16658 sp HG2A_RAT 42.308 78 42 2 277 351 179 256 3.36E-09 62.4 HG2A_RAT reviewed H-2 class II histocompatibility antigen gamma chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74) Cd74 Rattus norvegicus (Rat) 280 "activation of MAPK activity [GO:0000187]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell proliferation [GO:0008283]; chaperone mediated protein folding requiring cofactor [GO:0051085]; defense response [GO:0006952]; immunoglobulin mediated immune response [GO:0016064]; intracellular protein transport [GO:0006886]; macrophage migration inhibitory factor signaling pathway [GO:0035691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of peptide secretion [GO:0002792]; negative regulation of T cell differentiation [GO:0045581]; negative thymic T cell selection [GO:0045060]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type 2 immune response [GO:0002830]; positive thymic T cell selection [GO:0045059]; prostaglandin biosynthetic process [GO:0001516]; protein complex assembly [GO:0006461]" GO:0000187; GO:0001516; GO:0001540; GO:0001961; GO:0002606; GO:0002792; GO:0002830; GO:0002906; GO:0004896; GO:0005764; GO:0005771; GO:0005783; GO:0005794; GO:0006461; GO:0006886; GO:0006952; GO:0008283; GO:0009897; GO:0016021; GO:0016064; GO:0019886; GO:0019955; GO:0030890; GO:0035691; GO:0035692; GO:0035693; GO:0042613; GO:0043066; GO:0043518; GO:0045059; GO:0045060; GO:0045581; GO:0045582; GO:0048146; GO:0050731; GO:0050998; GO:0051085; GO:0060907; GO:0070062; GO:0070374; GO:0090023; GO:1902166; GO:2000343 0 0 0 PF09307;PF08831;PF00086; P18433 CHOYP_PTPRT.3.45 m.3535 sp PTPRA_HUMAN 29.749 716 447 23 1 679 95 791 3.36E-83 282 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P18699 CHOYP_LOC101061694.1.1 m.49905 sp TBB_LYMST 96.429 56 2 0 1 56 25 80 3.36E-34 117 TBB_LYMST reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 111 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P53470 CHOYP_ACT1.7.7 m.63917 sp ACT1_SCHMA 56 150 18 2 3 109 4 148 3.36E-44 150 ACT1_SCHMA reviewed Actin-1 0 Schistosoma mansoni (Blood fluke) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P83425 CHOYP_CBLN2.2.2 m.63806 sp HIP_MYTED 32 125 84 1 27 151 65 188 3.36E-10 59.7 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q0VA52 CHOYP_LOC101061197.1.1 m.23747 sp SPA5L_XENTR 39.589 341 199 2 69 408 151 485 3.36E-84 271 SPA5L_XENTR reviewed Spermatogenesis-associated protein 5-like protein 1 spata5l1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 593 0 GO:0005524; GO:0005737 0 0 0 PF00004; Q17R13 CHOYP_ACK1.1.1 m.63019 sp ACK1_BOVIN 46.259 147 58 6 1 133 1 140 3.36E-25 103 ACK1_BOVIN reviewed Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Activated CDC42 kinase 2) (Tyrosine kinase non-receptor protein 2) TNK2 ACK1 ACK2 Bos taurus (Bovine) 1039 cell differentiation [GO:0030154]; cell migration [GO:0016477]; endocytosis [GO:0006897]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; regulation of cell proliferation [GO:0042127]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004674; GO:0004715; GO:0005102; GO:0005524; GO:0005634; GO:0005737; GO:0005768; GO:0005886; GO:0005905; GO:0005912; GO:0006897; GO:0007169; GO:0016310; GO:0016477; GO:0030136; GO:0030154; GO:0030659; GO:0031234; GO:0038083; GO:0042127; GO:0045087; GO:0046872 0 0 0 PF09027;PF11555;PF07714;PF14604; Q28824 CHOYP_MYLK.4.4 m.58648 sp MYLK_BOVIN 36.932 880 453 13 1783 2635 355 1159 3.36E-171 565 MYLK_BOVIN reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK Bos taurus (Bovine) 1176 positive regulation of cell migration [GO:0030335]; smooth muscle contraction [GO:0006939] GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0006939; GO:0030027; GO:0030335; GO:0032154; GO:0046872 0 0 0 PF00041;PF07679;PF00069; Q28HU3 CHOYP_CENPO.1.1 m.16774 sp CENPO_XENTR 28.807 243 156 11 30 262 48 283 3.36E-12 68.6 CENPO_XENTR reviewed Centromere protein O (CENP-O) cenpo TGas100d11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 303 centromere complex assembly [GO:0034508] GO:0000776; GO:0005634; GO:0034508 0 0 0 PF09496; Q3SX40 CHOYP_PDLI2.2.3 m.17095 sp PDLI7_BOVIN 43.902 82 46 0 2 83 3 84 3.36E-17 87.8 PDLI7_BOVIN reviewed PDZ and LIM domain protein 7 PDLIM7 Bos taurus (Bovine) 424 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; ossification [GO:0001503] GO:0001503; GO:0005737; GO:0005856; GO:0007275; GO:0008270; GO:0030154 0 0 0 PF00412;PF00595; Q460N5 CHOYP_BRAFLDRAFT_74874.4.9 m.38618 sp PAR14_HUMAN 26.395 663 430 15 2 642 523 1149 3.36E-49 189 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q567G2 CHOYP_WDR73.1.1 m.17061 sp WDR73_DANRE 30.914 372 229 11 23 371 1 367 3.36E-42 154 WDR73_DANRE reviewed WD repeat-containing protein 73 wdr73 zgc:112071 Danio rerio (Zebrafish) (Brachydanio rerio) 376 cerebellar Purkinje cell differentiation [GO:0021702]; cerebellum development [GO:0021549]; midbrain development [GO:0030901] GO:0000922; GO:0005829; GO:0021549; GO:0021702; GO:0030901; GO:0032154 0 0 0 PF00400; Q5BLE8 CHOYP_BRAFLDRAFT_119025.1.3 m.7630 sp RETST_DANRE 40.165 605 354 4 40 644 10 606 3.36E-170 502 RETST_DANRE reviewed "Putative all-trans-retinol 13,14-reductase (EC 1.3.99.23) (All-trans-13,14-dihydroretinol saturase) (RetSat)" retsat zgc:113107 Danio rerio (Zebrafish) (Brachydanio rerio) 607 0 GO:0016020; GO:0051786 0 0 0 PF01593; Q5TYM5 CHOYP_BRAFLDRAFT_276331.1.1 m.1381 sp FA72A_HUMAN 40.559 143 82 1 10 149 7 149 3.36E-39 132 FA72A_HUMAN reviewed Protein FAM72A (Latent membrane protein 1-induced protein) (LMP1-induced protein) (LMPIP) FAM72A UGENE Homo sapiens (Human) 149 0 GO:0005737; GO:0005739; GO:0043231 0 0 0 PF14976; Q5ZJL9 CHOYP_LOC566621.1.1 m.45550 sp SAMH1_CHICK 42.67 382 200 5 2 364 87 468 3.36E-93 300 SAMH1_CHICK reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) 614 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966; Q62415 CHOYP_LOC100646232.1.1 m.19970 sp ASPP1_MOUSE 58.167 251 103 1 869 1117 835 1085 3.36E-91 320 ASPP1_MOUSE reviewed Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B) Ppp1r13b Aspp1 Mus musculus (Mouse) 1087 intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of cell cycle [GO:0045786] GO:0002039; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0045786; GO:0072332; GO:0097193 0 0 0 PF12796;PF00018; Q6NW40 CHOYP_BRAFLDRAFT_82627.1.1 m.21863 sp RGMB_HUMAN 40.187 321 182 4 62 374 82 400 3.36E-67 223 RGMB_HUMAN reviewed RGM domain family member B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON) RGMB Homo sapiens (Human) 437 "BMP signaling pathway [GO:0030509]; cell adhesion [GO:0007155]; positive regulation of transcription, DNA-templated [GO:0045893]; signal transduction [GO:0007165]" GO:0005793; GO:0005886; GO:0007155; GO:0007165; GO:0015026; GO:0030509; GO:0042802; GO:0045121; GO:0045893; GO:0046658 0 0 0 PF06534;PF06535; Q6R7B3 CHOYP_DPOL.1.1 m.30090 sp Y002_OSHVF 98.802 167 2 0 1 167 1 167 3.36E-119 336 Y002_OSHVF reviewed Uncharacterized protein ORF2 ORF2 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 167 0 0 0 0 0 0 Q6R7B3 CHOYP_Y003.1.1 m.31012 sp Y002_OSHVF 98.802 167 2 0 1 167 1 167 3.36E-119 336 Y002_OSHVF reviewed Uncharacterized protein ORF2 ORF2 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 167 0 0 0 0 0 0 Q6TGY8 CHOYP_EMC2.1.2 m.12120 sp EMC2_DANRE 52.124 259 122 1 9 265 10 268 3.36E-94 290 EMC2_DANRE reviewed ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) emc2 ttc35 zgc:86891 Danio rerio (Zebrafish) (Brachydanio rerio) 297 0 GO:0005634; GO:0005737; GO:0005783; GO:0072546 0 0 0 0 Q789F3 CHOYP_LOC100699096.1.1 m.32321 sp MAF_CHICK 51.24 121 48 2 205 325 247 356 3.36E-28 115 MAF_CHICK reviewed Transcription factor Maf (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) MAF Gallus gallus (Chicken) 359 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0001228; GO:0005634; GO:0006357; GO:0043565 0 0 0 PF03131;PF08383; Q789F3 CHOYP_LOC100699096.1.1 m.32322 sp MAF_CHICK 51.24 121 48 2 205 325 247 356 3.36E-28 115 MAF_CHICK reviewed Transcription factor Maf (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) MAF Gallus gallus (Chicken) 359 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0001228; GO:0005634; GO:0006357; GO:0043565 0 0 0 PF03131;PF08383; Q7TSV3 CHOYP_ZMY19.1.1 m.10576 sp ZMY19_RAT 54.741 232 100 4 1 232 1 227 3.36E-89 265 ZMY19_RAT reviewed Zinc finger MYND domain-containing protein 19 (Melanin-concentrating hormone receptor 1-interacting zinc finger protein) (MCH-R1-interacting zinc finger protein) Zmynd19 Mizip Rattus norvegicus (Rat) 227 0 GO:0005737; GO:0005886; GO:0045202; GO:0046872 0 0 0 PF13392;PF01753; Q8BW86 CHOYP_LOC757100.1.1 m.14462 sp ARG33_MOUSE 22.524 515 302 16 95 523 5 508 3.36E-19 97.4 ARG33_MOUSE reviewed Rho guanine nucleotide exchange factor 33 Arhgef33 Gm941 Mus musculus (Mouse) 850 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF00621; Q8C0J6 CHOYP_LOC410299.1.1 m.23623 sp SWAHC_MOUSE 46.774 124 61 1 202 320 246 369 3.36E-34 135 SWAHC_MOUSE reviewed Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) Sowahc Ankrd57 Mus musculus (Mouse) 512 0 0 0 0 0 PF12796; Q8C525 CHOYP_LOC100373864.2.2 m.55133 sp M21D2_MOUSE 29.333 150 101 4 2 148 207 354 3.36E-09 60.8 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8NEP7 CHOYP_SMP_127750.1.2 m.36071 sp KLDC9_HUMAN 28.662 314 197 9 28 321 29 335 3.36E-27 112 KLDC9_HUMAN reviewed Kelch domain-containing protein 9 (Kelch/ankyrin repeat-containing cyclin A1-interacting protein) KLHDC9 KARCA1 Homo sapiens (Human) 349 0 0 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208293.11.20 m.53922 sp HS12B_HUMAN 32.951 610 327 17 26 581 54 635 3.36E-96 311 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9D1C9 CHOYP_LOC100691983.1.1 m.16476 sp RRP7A_MOUSE 43.13 262 142 4 12 269 22 280 3.36E-67 213 RRP7A_MOUSE reviewed Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14 homolog) Rrp7a Mus musculus (Mouse) 280 blastocyst formation [GO:0001825]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364] GO:0000028; GO:0000166; GO:0001825; GO:0005737; GO:0006364; GO:0032545; GO:0034456; GO:0044822 0 0 0 PF12923; Q9JK45 CHOYP_LOC100903861.1.1 m.51707 sp KCNQ5_MOUSE 43.75 672 319 15 97 736 87 731 3.36E-164 504 KCNQ5_MOUSE reviewed Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) Kcnq5 Mus musculus (Mouse) 933 potassium ion transport [GO:0006813] GO:0005249; GO:0005251; GO:0006813; GO:0008076; GO:0016021; GO:0030118 0 0 0 PF00520;PF03520; Q9NZL6 CHOYP_LOC655842.1.1 m.24679 sp RGL1_HUMAN 39.541 741 364 17 16 682 15 745 3.36E-161 486 RGL1_HUMAN reviewed Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) RGL1 KIAA0959 RGL Homo sapiens (Human) 768 small GTPase mediated signal transduction [GO:0007264] GO:0005829; GO:0007264; GO:0008321 0 0 cd06224; PF00788;PF00617;PF00618; Q9W0Y2 CHOYP_YS11.1.1 m.30657 sp YS11_DROME 41.06 151 85 3 19 168 10 157 3.36E-32 115 YS11_DROME reviewed Putative gamma-glutamylcyclotransferase CG2811 (EC 2.3.2.-) CG2811 Drosophila melanogaster (Fruit fly) 157 0 GO:0016746 0 0 cd06661; PF06094; A9ULZ2 CHOYP_BIR7B.1.2 m.14255 sp BIR7B_XENLA 36.667 360 176 8 12 369 36 345 3.37E-64 211 BIR7B_XENLA reviewed Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) 345 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; B2RUR8 CHOYP_LOC581645.1.1 m.41228 sp OTU7B_MOUSE 42.144 541 220 11 380 843 130 654 3.37E-120 393 OTU7B_MOUSE reviewed OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) Otud7b Mus musculus (Mouse) 840 mucosal immune response [GO:0002385]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536] GO:0000122; GO:0002385; GO:0003677; GO:0004843; GO:0005634; GO:0005737; GO:0008234; GO:0008270; GO:0016579; GO:0032717; GO:0035871; GO:0043124; GO:0070530; GO:0070536; GO:0071108; GO:0071947; GO:1900181; GO:1990380 0 0 0 PF02338;PF01754; O01761 CHOYP_DSCL.1.1 m.3396 sp UNC89_CAEEL 23.375 646 386 26 75 693 4312 4875 3.37E-16 87.8 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O42643 CHOYP_PY00835.1.1 m.2533 sp PRP22_SCHPO 49.479 192 93 2 847 1037 508 696 3.37E-52 203 PRP22_SCHPO reviewed Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22 (EC 3.6.4.13) prp22 SPAC10F6.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1168 "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex disassembly [GO:0000390]" GO:0000390; GO:0000398; GO:0004004; GO:0005524; GO:0005634; GO:0005681; GO:0005684; GO:0005737; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF07717;PF00575; O60469 CHOYP_AAEL_AAEL001227.1.1 m.43502 sp DSCAM_HUMAN 26.778 239 143 9 199 421 757 979 3.37E-08 60.5 DSCAM_HUMAN reviewed Down syndrome cell adhesion molecule (CHD2) DSCAM Homo sapiens (Human) 2012 camera-type eye photoreceptor cell differentiation [GO:0060219]; cell adhesion [GO:0007155]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; locomotory behavior [GO:0007626]; negative regulation of cell adhesion [GO:0007162]; nervous system development [GO:0007399]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] GO:0005576; GO:0005886; GO:0005887; GO:0007155; GO:0007156; GO:0007162; GO:0007399; GO:0007416; GO:0007626; GO:0010842; GO:0016020; GO:0030054; GO:0030424; GO:0030426; GO:0042327; GO:0045202; GO:0048813; GO:0048842; GO:0060060; GO:0060219; GO:0070593 0 0 0 PF00041;PF07679; O93327 CHOYP_LOC100369232.1.1 m.58420 sp H2AY_CHICK 56.693 381 149 7 1 375 1 371 3.37E-133 388 H2AY_CHICK reviewed Core histone macro-H2A.1 (Histone macroH2A1) (mH2A1) (H2A.y) (H2A/y) H2AFY Gallus gallus (Chicken) 372 "chromatin silencing [GO:0006342]; covalent chromatin modification [GO:0016569]; dosage compensation [GO:0007549]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of histone H3-K27 methylation [GO:0061086]; negative regulation of histone H3-K4 methylation [GO:0051572]; negative regulation of histone phosphorylation [GO:0033128]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901837]; nucleosome assembly [GO:0006334]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of keratinocyte differentiation [GO:0045618]; regulation of histone methylation [GO:0031060]; regulation of lipid metabolic process [GO:0019216]" GO:0000122; GO:0000182; GO:0000784; GO:0000786; GO:0000790; GO:0000793; GO:0000979; GO:0003677; GO:0005721; GO:0005730; GO:0006334; GO:0006342; GO:0007549; GO:0010385; GO:0016569; GO:0019216; GO:0030291; GO:0031060; GO:0031490; GO:0033128; GO:0035098; GO:0045618; GO:0045815; GO:0051572; GO:0061086; GO:0070062; GO:0071169; GO:1901837; GO:1902750 0 0 0 PF00125;PF16211;PF01661; P01026 CHOYP_CO3.1.1 m.40318 sp CO3_RAT 27.542 1721 1038 53 20 1662 26 1615 3.37E-166 551 CO3_RAT reviewed Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc) (Neutrophil chemotactic factor-2) (ENCF-2); Complement C3 alpha chain; C3a anaphylatoxin (Neutrophil chemotactic factor-1) (ENCF-1); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] C3 Rattus norvegicus (Rat) 1663 "blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; complement activation, classical pathway [GO:0006958]; fatty acid metabolic process [GO:0006631]; inflammatory response [GO:0006954]; positive regulation of developmental growth [GO:0048639]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose transport [GO:0010828]; positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745]; positive regulation of lipid storage [GO:0010884]; positive regulation of protein phosphorylation [GO:0001934]; regulation of triglyceride biosynthetic process [GO:0010866]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to magnesium ion [GO:0032026]; response to progesterone [GO:0032570]; tolerance induction [GO:0002507]" GO:0001934; GO:0002507; GO:0004866; GO:0005615; GO:0006631; GO:0006935; GO:0006954; GO:0006956; GO:0006957; GO:0006958; GO:0007596; GO:0008289; GO:0010828; GO:0010866; GO:0010884; GO:0031715; GO:0032026; GO:0032355; GO:0032570; GO:0043627; GO:0045745; GO:0048037; GO:0048639; GO:0051384; GO:0070374 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF01821;PF01759;PF10569; P02259 CHOYP_CBR-GLY-5.1.1 m.26443 sp H5_CHICK 43.066 137 63 4 1 123 1 136 3.37E-23 94.4 H5_CHICK reviewed Histone H5 0 Gallus gallus (Chicken) 190 chromosome condensation [GO:0030261]; nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0030261 0 0 0 PF00538; P02259 CHOYP_LOC100635715.3.9 m.10850 sp H5_CHICK 43.066 137 63 4 1 123 1 136 3.37E-23 93.6 H5_CHICK reviewed Histone H5 0 Gallus gallus (Chicken) 190 chromosome condensation [GO:0030261]; nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0030261 0 0 0 PF00538; P41105 CHOYP_LOC101170942.1.1 m.47597 sp RL28_MOUSE 59.055 127 52 0 3 129 2 128 3.37E-52 164 RL28_MOUSE reviewed 60S ribosomal protein L28 Rpl28 Mus musculus (Mouse) 137 positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; translation [GO:0006412] GO:0003735; GO:0005737; GO:0006412; GO:0016020; GO:0022625; GO:0030425; GO:0036464; GO:0044297; GO:0044822; GO:0070062; GO:1903146; GO:1903955 0 0 0 PF01778; P41105 CHOYP_LOC552398.2.2 m.39853 sp RL28_MOUSE 59.055 127 52 0 3 129 2 128 3.37E-52 164 RL28_MOUSE reviewed 60S ribosomal protein L28 Rpl28 Mus musculus (Mouse) 137 positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; translation [GO:0006412] GO:0003735; GO:0005737; GO:0006412; GO:0016020; GO:0022625; GO:0030425; GO:0036464; GO:0044297; GO:0044822; GO:0070062; GO:1903146; GO:1903955 0 0 0 PF01778; Q03145 CHOYP_LOC100881175.1.2 m.38171 sp EPHA2_MOUSE 37.643 263 145 7 976 1230 616 867 3.37E-48 191 EPHA2_MOUSE reviewed Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2) Epha2 Eck Myk2 Sek2 Mus musculus (Mouse) 977 activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel morphogenesis [GO:0048514]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production [GO:0001818]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of protein kinase B signaling [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; post-anal tail morphogenesis [GO:0036342]; protein kinase B signaling [GO:0043491]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570] GO:0001501; GO:0001568; GO:0001570; GO:0001649; GO:0001818; GO:0002043; GO:0004714; GO:0005003; GO:0005524; GO:0005622; GO:0005886; GO:0005887; GO:0005925; GO:0006954; GO:0007155; GO:0008630; GO:0009986; GO:0010591; GO:0014028; GO:0016477; GO:0016525; GO:0021915; GO:0030182; GO:0030216; GO:0030316; GO:0031256; GO:0031258; GO:0032587; GO:0032682; GO:0033598; GO:0033628; GO:0036342; GO:0043491; GO:0043535; GO:0045765; GO:0046849; GO:0048013; GO:0048320; GO:0048514; GO:0048570; GO:0050830; GO:0051898; GO:0060035; GO:0060326; GO:0060444; GO:0070309; GO:0070372; GO:0070848; GO:0090004; GO:0090630; GO:1901491; GO:1904238 0 0 0 PF14575;PF01404;PF00041;PF07714;PF00536; Q08874 CHOYP_LOC100313655.1.1 m.52035 sp MITF_MOUSE 36.667 420 210 13 3 377 4 412 3.37E-66 224 MITF_MOUSE reviewed Microphthalmia-associated transcription factor Mitf Bw Mi Vit Mus musculus (Mouse) 526 "bone remodeling [GO:0046849]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; mast cell migration [GO:0097531]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoclast differentiation [GO:0030316]; pigmentation [GO:0043473]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein complex assembly [GO:0006461]; regulation of cell proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription, DNA-templated [GO:0006355]; Wnt signaling pathway [GO:0016055]" GO:0000122; GO:0000978; GO:0000979; GO:0001077; GO:0003677; GO:0003682; GO:0003700; GO:0003705; GO:0005634; GO:0006355; GO:0006461; GO:0010468; GO:0010628; GO:0016055; GO:0030154; GO:0030316; GO:0030318; GO:0042127; GO:0043010; GO:0043066; GO:0043234; GO:0043473; GO:0043565; GO:0044336; GO:0045165; GO:0045670; GO:0045893; GO:0045944; GO:0046849; GO:0097531; GO:2000144; GO:2001141 0 0 0 PF11851;PF00010;PF15951; Q2EMV9 CHOYP_PARP14.9.22 m.36204 sp PAR14_MOUSE 45.238 210 113 2 30 239 1609 1816 3.37E-51 182 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q3SX11 CHOYP_BRAFLDRAFT_60200.2.3 m.33252 sp NSA2_BOVIN 81.2 250 47 0 13 262 11 260 3.37E-153 430 NSA2_BOVIN reviewed Ribosome biogenesis protein NSA2 homolog (TGF-beta-inducible nuclear protein 1) NSA2 TINP1 Bos taurus (Bovine) 260 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0005730; GO:0030687; GO:0044822 0 0 0 PF01201; Q460N3 CHOYP_LOC100484022.2.2 m.62335 sp PAR15_HUMAN 31.046 612 373 15 612 1198 89 676 3.37E-77 272 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q49A92 CHOYP_NEMVEDRAFT_V1G215851.1.2 m.1117 sp CH034_HUMAN 33.929 168 89 8 6 170 1 149 3.37E-11 63.9 CH034_HUMAN reviewed Uncharacterized protein C8orf34 (Protein VEST-1) C8orf34 Homo sapiens (Human) 452 0 0 0 0 0 0 Q53G44 CHOYP_SI_CH211-197G15.10.3.7 m.20276 sp IF44L_HUMAN 31.519 441 266 9 23 456 24 435 3.37E-56 196 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q6CX49 CHOYP_LOC100368265.1.1 m.62885 sp VAC8_KLULA 37.5 104 58 3 145 248 111 207 3.37E-07 56.6 VAC8_KLULA reviewed Vacuolar protein 8 VAC8 KLLA0A11286g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) 579 "CVT vesicle assembly [GO:0071255]; macroautophagy [GO:0016236]; nucleus-vacuole junction assembly [GO:0071562]; vacuole fusion, non-autophagic [GO:0042144]; vacuole inheritance [GO:0000011]" GO:0000011; GO:0000329; GO:0005794; GO:0016236; GO:0042144; GO:0071255; GO:0071561; GO:0071562; GO:0071563 0 0 0 PF00514; Q6DE75 CHOYP_S2538.2.2 m.22855 sp S2538_XENLA 54.348 92 42 0 37 128 210 301 3.37E-28 107 S2538_XENLA reviewed Solute carrier family 25 member 38 slc25a38 Xenopus laevis (African clawed frog) 302 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783] GO:0005215; GO:0005743; GO:0006783; GO:0016021; GO:0030218 0 0 0 PF00153; Q6P1C1 CHOYP_IPPK.2.2 m.56920 sp IPPK_MOUSE 31.034 522 292 16 9 512 13 484 3.37E-57 201 IPPK_MOUSE reviewed "Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)" Ippk Mus musculus (Mouse) 489 inositol phosphate biosynthetic process [GO:0032958]; inositol phosphorylation [GO:0052746]; mitophagy in response to mitochondrial depolarization [GO:0098779] GO:0005524; GO:0005622; GO:0005634; GO:0005737; GO:0032958; GO:0035299; GO:0052746; GO:0098779 0 0 0 PF06090; Q6P3P4 CHOYP_LOC654911.1.1 m.11177 sp KCD15_XENTR 56.41 234 88 2 89 322 18 237 3.37E-92 278 KCD15_XENTR reviewed BTB/POZ domain-containing protein kctd15 (Potassium channel tetramerization domain-containing protein 15) kctd15 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 255 multicellular organism development [GO:0007275]; protein homooligomerization [GO:0051260] GO:0007275; GO:0051260 0 0 0 PF02214; Q6ZPT1 CHOYP_KLH36.1.2 m.12244 sp KLHL9_MOUSE 29.137 556 344 18 314 847 50 577 3.37E-53 199 KLHL9_MOUSE reviewed Kelch-like protein 9 Klhl9 Kiaa1354 Mus musculus (Mouse) 617 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6ZRF8 CHOYP_LOC100374741.54.83 m.47294 sp RN207_HUMAN 21.827 197 132 7 52 242 103 283 3.37E-08 59.3 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q80TE7 CHOYP_BRAFLDRAFT_206003.2.2 m.58151 sp LRRC7_MOUSE 51.662 331 152 2 1 329 154 478 3.37E-103 358 LRRC7_MOUSE reviewed Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) Lrrc7 Kiaa1365 Lap1 Mus musculus (Mouse) 1490 0 GO:0005737; GO:0014069; GO:0030054; GO:0045211 0 0 0 PF13855;PF00595; Q8CDF7 CHOYP_LOC100875978.1.1 m.34640 sp EXD1_MOUSE 40 95 48 3 62 152 155 244 3.37E-07 56.6 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q8ISN9 CHOYP_RS25.4.11 m.13378 sp RS25_BRABE 77.011 87 20 0 39 125 28 114 3.37E-36 123 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8SWR3 CHOYP_SPR.2.3 m.21888 sp SPR_DROME 28.689 244 165 5 11 246 71 313 3.37E-20 92 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q9CWK3 CHOYP_BRAFLDRAFT_85822.1.1 m.10102 sp CD2B2_MOUSE 40.87 345 168 9 12 349 27 342 3.37E-65 213 CD2B2_MOUSE reviewed CD2 antigen cytoplasmic tail-binding protein 2 (CD2 cytoplasmic domain-binding protein 2) (CD2 tail-binding protein 2) Cd2bp2 Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; negative regulation of phosphatase activity [GO:0010923]; RNA splicing [GO:0008380] GO:0005634; GO:0005654; GO:0005682; GO:0005737; GO:0006397; GO:0008380; GO:0010923; GO:0016607; GO:0043021 0 0 0 PF02213; Q9D3W4 CHOYP_GPN3.1.2 m.6648 sp GPN3_MOUSE 70.722 263 76 1 1 263 1 262 3.37E-139 396 GPN3_MOUSE reviewed GPN-loop GTPase 3 (ATP-binding domain 1 family member C) Gpn3 Atpbd1c D5Ertd708e Mus musculus (Mouse) 284 0 GO:0005525; GO:0016787; GO:0043234 0 0 0 PF03029; Q9ESN6 CHOYP_BRAFLDRAFT_93988.2.3 m.3231 sp TRIM2_MOUSE 29.545 220 132 8 85 293 536 743 3.37E-13 73.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NQR1 CHOYP_TMO_0856.3.3 m.59923 sp KMT5A_HUMAN 37.324 142 80 5 31 168 257 393 3.37E-18 85.1 KMT5A_HUMAN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A PRSET7 SET07 SET8 SETD8 Homo sapiens (Human) 393 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006351; GO:0007067; GO:0016278; GO:0016279; GO:0018024; GO:0018026; GO:0042799; GO:0043516; GO:0045892; GO:0051301; GO:1901796 0 0 0 PF00856; Q9P2S5 CHOYP_LOC100368359.1.2 m.30665 sp WRP73_HUMAN 50.649 77 38 0 20 96 367 443 3.37E-21 89.7 WRP73_HUMAN reviewed WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene) WRAP73 WDR8 Homo sapiens (Human) 460 cell projection organization [GO:0030030]; mitotic spindle assembly [GO:0090307]; positive regulation of nonmotile primary cilium assembly [GO:1902857] GO:0005813; GO:0005814; GO:0030030; GO:0036064; GO:0090307; GO:1902857 0 0 0 PF12894; Q9WVG9 CHOYP_MSL3.1.1 m.55033 sp MS3L1_MOUSE 32.082 586 308 12 2 576 3 509 3.37E-77 256 MS3L1_MOUSE reviewed Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) Msl3 Msl31 Msl3l1 Mus musculus (Mouse) 525 "chromatin modification [GO:0016568]; chromatin remodeling [GO:0006338]; chromatin silencing [GO:0006342]; histone deacetylation [GO:0016575]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; histone H4-K16 acetylation [GO:0043984]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0006338; GO:0006342; GO:0006351; GO:0016568; GO:0016575; GO:0035064; GO:0035267; GO:0043967; GO:0043968; GO:0043984; GO:0072487 0 0 0 PF05712;PF11717; A0JMD4 CHOYP_TPC2.2.2 m.36986 sp TPC2_DANRE 42.418 455 219 8 86 533 58 476 3.38E-101 325 TPC2_DANRE reviewed Two pore calcium channel protein 2 (Voltage-dependent calcium channel protein TPC2) tpcn2 tpc2 zgc:152898 Danio rerio (Zebrafish) (Brachydanio rerio) 774 membrane depolarization during action potential [GO:0086010]; smooth muscle contraction [GO:0006939] GO:0005245; GO:0005764; GO:0005765; GO:0005886; GO:0006939; GO:0016021; GO:0072345; GO:0086010 0 0 0 PF00520; A2A690 CHOYP_TVAG_470020.7.8 m.32581 sp TANC2_MOUSE 32.099 162 91 4 574 735 1028 1170 3.38E-15 84 TANC2_MOUSE reviewed "Protein TANC2 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2)" Tanc2 Kiaa1148 Mus musculus (Mouse) 1994 in utero embryonic development [GO:0001701] GO:0001701 0 0 0 PF00023;PF12796;PF13181; A8WGS4 CHOYP_SMP_140510.3.3 m.52018 sp TLCD2_DANRE 34.975 203 131 1 67 269 30 231 3.38E-43 150 TLCD2_DANRE reviewed TLC domain-containing protein 2 tlcd2 zgc:175098 Danio rerio (Zebrafish) (Brachydanio rerio) 246 0 GO:0016021 0 0 0 PF03798; D3YXG0 CHOYP_BRAFLDRAFT_88566.1.11 m.2935 sp HMCN1_MOUSE 39.869 306 161 11 11 297 4510 4811 3.38E-52 195 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E1BJS7 CHOYP_ZF_BBOX_RING_-1.3.10 m.29555 sp LIN41_BOVIN 23.932 234 146 5 11 229 196 412 3.38E-10 66.6 LIN41_BOVIN reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Bos taurus (Bovine) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O02389 CHOYP_TPM.3.19 m.7778 sp TPM_CHLNI 65.766 111 38 0 6 116 123 233 3.38E-38 133 TPM_CHLNI reviewed Tropomyosin 0 Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) 284 0 0 0 0 0 PF00261; O02722 CHOYP_LOC753842.1.1 m.21163 sp TIMP1_HORSE 30.516 213 121 8 50 254 10 203 3.38E-18 83.6 TIMP1_HORSE reviewed Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Equus caballus (Horse) 207 negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; positive regulation of cell proliferation [GO:0008284]; regulation of integrin-mediated signaling pathway [GO:2001044]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] GO:0002020; GO:0005125; GO:0005578; GO:0005615; GO:0008191; GO:0008284; GO:0009725; GO:0010951; GO:0034097; GO:0043086; GO:0046872; GO:0051045; GO:2001044 0 0 0 PF00965; O57429 CHOYP_LOC100875987.2.2 m.63380 sp UBP2_CHICK 26.608 342 193 15 181 477 21 349 3.38E-17 86.3 UBP2_CHICK reviewed Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Gallus gallus (Chicken) 357 protein deubiquitination [GO:0016579]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0016579; GO:0046872; GO:0048471; GO:0048511 0 0 0 PF00443; O96064 CHOYP_MYSP.3.9 m.2164 sp MYSP_MYTGA 69.841 126 32 3 21 144 525 646 3.38E-44 158 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P08060 CHOYP_LOC100158373.1.1 m.45528 sp CAH6_SHEEP 38.929 280 159 6 47 321 3 275 3.38E-59 196 CAH6_SHEEP reviewed Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase) CA6 Ovis aries (Sheep) 307 one-carbon metabolic process [GO:0006730] GO:0004089; GO:0005576; GO:0006730; GO:0008270 0 0 0 PF00194; P09487 CHOYP_ALPL.2.2 m.44534 sp PPBT_BOVIN 51.563 192 92 1 1 191 1 192 3.38E-53 180 PPBT_BOVIN reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) 524 biomineral tissue development [GO:0031214]; cellular response to organic cyclic compound [GO:0071407]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; osteoblast differentiation [GO:0001649]; response to antibiotic [GO:0046677]; response to vitamin D [GO:0033280] GO:0001649; GO:0001958; GO:0003006; GO:0004035; GO:0005578; GO:0005886; GO:0016462; GO:0031214; GO:0031225; GO:0033280; GO:0046677; GO:0046872; GO:0065010; GO:0070062; GO:0071407 0 0 0 PF00245; P18433 CHOYP_PTPRE.16.19 m.53772 sp PTPRA_HUMAN 28.393 722 485 17 360 1060 90 800 3.38E-75 268 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P21328 CHOYP_LOC100887947.1.2 m.35559 sp RTJK_DROME 28.687 495 316 13 3 469 354 839 3.38E-41 163 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P24733 CHOYP_MYS.2.7 m.2072 sp MYS_ARGIR 73.596 178 47 0 1 178 912 1089 3.38E-65 220 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P27634 CHOYP_EF1A2.2.3 m.37043 sp EF1A_RHYAM 90.805 87 8 0 27 113 4 90 3.38E-52 172 EF1A_RHYAM reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Rhynchosciara americana (Fungus gnat) 412 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; P42674 CHOYP_LOC100377541.2.4 m.15307 sp BP10_PARLI 36.432 398 224 11 60 441 64 448 3.38E-66 225 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P79943 CHOYP_BRAFLDRAFT_202693.1.4 m.6381 sp SLBP1_XENLA 65.823 79 26 1 134 211 125 203 3.38E-31 119 SLBP1_XENLA reviewed Histone RNA hairpin-binding protein (Histone stem-loop-binding protein 1) slbp1 hbp slbp Xenopus laevis (African clawed frog) 254 mRNA processing [GO:0006397] GO:0003729; GO:0005634; GO:0005737; GO:0006397 0 0 0 PF15247; P86861 CHOYP_FND.1.1 m.66850 sp FND_MYTCA 36.054 147 81 4 4 141 1 143 3.38E-17 77.8 FND_MYTCA reviewed Fibronectin type III domain-containing protein (Fibronectin-like protein) (Fragment) 0 Mytilus californianus (California mussel) 225 0 GO:0005576 0 0 0 PF00041; Q1ZXD6 CHOYP_BRAFLDRAFT_129004.10.15 m.44563 sp ROCO5_DICDI 22.759 290 176 10 412 692 1337 1587 3.38E-09 65.5 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q503L9 CHOYP_LOC100633077.2.4 m.11871 sp NXN_DANRE 51.429 105 51 0 44 148 179 283 3.38E-34 126 NXN_DANRE reviewed Nucleoredoxin (EC 1.8.1.8) nxn zgc:110449 Danio rerio (Zebrafish) (Brachydanio rerio) 418 cardiovascular system development [GO:0072358]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005829; GO:0016055; GO:0030154; GO:0030178; GO:0031397; GO:0045454; GO:0047134; GO:0072358 0 0 0 PF13905; Q5BKW7 CHOYP_ENPP6.4.5 m.48632 sp ENPP6_DANRE 40.984 366 203 6 5 360 8 370 3.38E-96 296 ENPP6_DANRE reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine cholinephosphodiesterase) (GPC-Cpde) enpp6 zgc:103605 Danio rerio (Zebrafish) (Brachydanio rerio) 438 choline metabolic process [GO:0019695]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629] GO:0005886; GO:0006629; GO:0008081; GO:0016042; GO:0019695; GO:0031225; GO:0047390 0 0 0 PF01663; Q5WR10 CHOYP_DDX39B.1.1 m.36283 sp DX39B_CANLF 65.031 163 57 0 1 163 83 245 3.38E-72 227 DX39B_CANLF reviewed Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) DDX39B BAT1 UAP56 Canis lupus familiaris (Dog) (Canis familiaris) 428 "cellular response to DNA damage stimulus [GO:0006974]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of gene expression [GO:0010468]; RNA secondary structure unwinding [GO:0010501]; spliceosomal complex assembly [GO:0000245]; viral mRNA export from host cell nucleus [GO:0046784]" GO:0000245; GO:0000346; GO:0000398; GO:0004004; GO:0005524; GO:0005681; GO:0005687; GO:0005688; GO:0005737; GO:0006406; GO:0006974; GO:0010468; GO:0010501; GO:0016607; GO:0017070; GO:0030621; GO:0032786; GO:0044822; GO:0046784; GO:2000002 0 0 0 PF00270;PF00271; Q6A4L1 CHOYP_LOC592204.1.1 m.62141 sp S12A8_XENLA 41.325 634 328 7 2 592 89 721 3.38E-162 483 S12A8_XENLA reviewed Solute carrier family 12 member 8 slc12a8 Xenopus laevis (African clawed frog) 721 potassium ion transport [GO:0006813] GO:0006813; GO:0015293; GO:0016021 0 0 0 PF00324; Q6DIB5 CHOYP_MEGF6.44.59 m.47511 sp MEG10_MOUSE 36.851 578 324 25 14 580 126 673 3.38E-76 265 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q7Z442 CHOYP_LOC100175984.1.1 m.36408 sp PK1L2_HUMAN 26.03 534 349 10 157 687 1817 2307 3.38E-53 202 PK1L2_HUMAN reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) PKD1L2 KIAA1879 PC1L2 Homo sapiens (Human) 2459 detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q8BUH1 CHOYP_TXN4B.1.1 m.48767 sp TXN4B_MOUSE 66.443 149 50 0 5 153 1 149 3.38E-74 221 TXN4B_MOUSE reviewed Thioredoxin-like protein 4B Txnl4b Mus musculus (Mouse) 149 "cell cycle [GO:0007049]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cell proliferation [GO:0008284]; spliceosomal complex assembly [GO:0000245]" GO:0000245; GO:0000398; GO:0005634; GO:0005681; GO:0005682; GO:0007049; GO:0008284; GO:0046540 0 0 0 PF02966; Q8C5H1 CHOYP_LOC100369417.1.2 m.31789 sp ANO4_MOUSE 30.015 653 316 19 21 624 118 678 3.38E-61 224 ANO4_MOUSE reviewed Anoctamin-4 (Transmembrane protein 16D) Ano4 Tmem16d Mus musculus (Mouse) 955 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821] GO:0005622; GO:0005886; GO:0006821; GO:0016021; GO:0017128; GO:0061589; GO:0061590; GO:0061591; GO:1902476 0 0 0 PF16178;PF04547; Q8WZ42 CHOYP_TITIN.6.19 m.31591 sp TITIN_HUMAN 29.187 1881 1049 52 2884 4674 942 2629 3.38E-178 628 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q96KG7 CHOYP_MEG10.16.91 m.22846 sp MEG10_HUMAN 39.506 324 170 17 7 327 268 568 3.38E-41 159 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q96LI6 CHOYP_HSFY1.1.1 m.46134 sp HSFY1_HUMAN 39.806 103 57 4 19 117 47 148 3.38E-12 68.9 HSFY1_HUMAN reviewed "Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like)" HSFY1 HSF2L HSFY; HSFY2 HSF2L HSFY Homo sapiens (Human) 401 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0043565 0 0 0 PF00447; Q99715 CHOYP_PIF.6.6 m.44699 sp COCA1_HUMAN 30 190 115 7 38 216 135 317 3.38E-16 85.9 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q9DBS2 CHOYP_LOC100368508.1.1 m.36078 sp TPRGL_MOUSE 31.818 176 111 4 25 199 2 169 3.38E-25 102 TPRGL_MOUSE reviewed Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A) Tprg1l Fam79a Mover Tprgl Mus musculus (Mouse) 266 0 GO:0008021; GO:0030054; GO:0042802; GO:0070062 0 0 0 PF12456; Q9HCI7 CHOYP_LOC100877046.1.1 m.56567 sp MSL2_HUMAN 29.677 310 142 8 1 259 1 285 3.38E-27 116 MSL2_HUMAN reviewed E3 ubiquitin-protein ligase MSL2 (EC 6.3.2.-) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184) MSL2 KIAA1585 MSL2L1 RNF184 Homo sapiens (Human) 577 histone H4-K16 acetylation [GO:0043984] GO:0005654; GO:0008270; GO:0016874; GO:0043984; GO:0061630; GO:0072487 0 0 cd13122; PF16682;PF16685; A2AJ76 CHOYP_LOC100313665.1.2 m.22475 sp HMCN2_MOUSE 25.397 693 395 36 19 645 2873 3509 3.39E-30 134 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A8DYE2 CHOYP_BRAFLDRAFT_118277.1.1 m.61321 sp TRPCG_DROME 24.111 1294 769 48 187 1405 179 1334 3.39E-77 288 TRPCG_DROME reviewed "Transient receptor potential cation channel trpm (Transient receptor potential cation channel, subfamily M ortholog)" Trpm CG44240 Drosophila melanogaster (Fruit fly) 2023 cell growth [GO:0016049]; divalent metal ion transport [GO:0070838]; magnesium ion homeostasis [GO:0010960]; mitochondrion organization [GO:0007005]; protein tetramerization [GO:0051262]; zinc ion homeostasis [GO:0055069] GO:0005261; GO:0007005; GO:0010960; GO:0016049; GO:0034703; GO:0046873; GO:0051262; GO:0055069; GO:0070838; GO:0097682 0 0 0 PF00520;PF16519; B2IZD3 CHOYP_BRAFLDRAFT_89870.1.1 m.15447 sp BDLP_NOSP7 26.374 182 119 5 57 235 51 220 3.39E-07 53.9 BDLP_NOSP7 reviewed Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5) Npun_R6513 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 693 0 GO:0003924; GO:0005525; GO:0005886; GO:0008289; GO:0016021 0 0 0 PF00350; D2GXS7 CHOYP_BRAFLDRAFT_69765.16.23 m.53314 sp TRIM2_AILME 21.961 255 178 6 72 308 492 743 3.39E-08 58.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43301 CHOYP_HS12A.31.33 m.63368 sp HS12A_HUMAN 33.923 622 356 11 64 634 56 673 3.39E-98 317 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O70277 CHOYP_LOC100369333.28.32 m.53859 sp TRIM3_RAT 25.483 259 160 11 309 554 506 744 3.39E-08 60.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75369 CHOYP_ISCW_ISCW006929.1.1 m.21431 sp FLNB_HUMAN 25.768 586 368 19 2 529 1306 1882 3.39E-42 166 FLNB_HUMAN reviewed Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) FLNB FLN1L FLN3 TABP TAP Homo sapiens (Human) 2602 actin cytoskeleton organization [GO:0030036]; cytoskeletal anchoring at plasma membrane [GO:0007016]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519] GO:0001725; GO:0003334; GO:0003382; GO:0003779; GO:0005737; GO:0005829; GO:0005886; GO:0005903; GO:0005913; GO:0005925; GO:0005938; GO:0007016; GO:0007165; GO:0007519; GO:0015629; GO:0016021; GO:0030018; GO:0030036; GO:0031012; GO:0042802; GO:0044822; GO:0070062; GO:0098641 0 0 0 PF00307;PF00630; O75382 CHOYP_BRAFLDRAFT_82426.2.20 m.13238 sp TRIM3_HUMAN 22.78 259 165 11 207 446 489 731 3.39E-06 53.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_87334.4.4 m.47082 sp TRIM3_HUMAN 34.483 87 48 3 57 134 477 563 3.39E-07 51.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02553 CHOYP_TBA1.6.9 m.40285 sp TBA_LYTPI 98.667 150 2 0 1 150 12 161 3.39E-109 310 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P06197 CHOYP_LOC583015.1.1 m.9208 sp PIS_YEAST 47.5 80 37 2 19 95 15 92 3.39E-12 66.2 PIS_YEAST reviewed CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) PIS1 PIS YPR113W P8283.5 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 220 phosphatidylinositol biosynthetic process [GO:0006661] GO:0003881; GO:0005741; GO:0005789; GO:0005794; GO:0006661; GO:0016021 0 0 0 PF01066; P10079 CHOYP_NEMVEDRAFT_V1G141380.2.4 m.8974 sp FBP1_STRPU 40.675 504 256 20 1 500 481 945 3.39E-83 286 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P25067 CHOYP_LOC101169268.1.2 m.22255 sp CO8A2_HUMAN 34.545 110 67 3 103 208 592 700 3.39E-09 59.3 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; P55265 CHOYP_DSRAD.1.4 m.4228 sp DSRAD_HUMAN 36.283 678 354 14 44 646 549 1223 3.39E-118 384 DSRAD_HUMAN reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) 1226 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337] GO:0001649; GO:0001701; GO:0002244; GO:0002566; GO:0003677; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006397; GO:0006606; GO:0006611; GO:0009615; GO:0016020; GO:0016553; GO:0030218; GO:0031054; GO:0035280; GO:0035455; GO:0043066; GO:0044387; GO:0044530; GO:0044822; GO:0045070; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060216; GO:0060337; GO:0060339; GO:0061484; GO:0098586; GO:1900369 0 0 0 PF02137;PF00035;PF02295; P81799 CHOYP_LOC586039.1.1 m.27100 sp NAGK_RAT 49.412 340 168 3 50 386 5 343 3.39E-116 344 NAGK_RAT reviewed N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) Nagk Rattus norvegicus (Rat) 343 N-acetylglucosamine metabolic process [GO:0006044]; N-acetylneuraminate catabolic process [GO:0019262] GO:0005524; GO:0006044; GO:0009384; GO:0019262; GO:0045127; GO:0070062 PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. 0 0 PF01869; Q460N5 CHOYP_PAR14.16.17 m.61603 sp PAR14_HUMAN 47.03 202 105 2 531 732 1601 1800 3.39E-49 191 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q60803 CHOYP_TRAF3.3.4 m.57955 sp TRAF3_MOUSE 26.042 288 186 7 1 274 98 372 3.39E-26 111 TRAF3_MOUSE reviewed TNF receptor-associated factor 3 (EC 6.3.2.-) (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN) Traf3 Craf1 Trafamn Mus musculus (Mouse) 567 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; toll-like receptor signaling pathway [GO:0002224]; Toll signaling pathway [GO:0008063]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001817; GO:0002224; GO:0004842; GO:0005164; GO:0005768; GO:0006915; GO:0008063; GO:0008270; GO:0009898; GO:0016874; GO:0019901; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032088; GO:0032648; GO:0033209; GO:0035631; GO:0042981; GO:0045087; GO:0050688 0 0 0 PF02176; Q640V3 CHOYP_LOC100891594.1.2 m.27216 sp NOL12_XENTR 39.2 125 66 2 17 133 1 123 3.39E-17 79.7 NOL12_XENTR reviewed Nucleolar protein 12 nol12 TNeu122o09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 216 0 GO:0005730; GO:0019843 0 0 0 PF09805; Q6PFY8 CHOYP_LOC100367817.3.7 m.48245 sp TRI45_MOUSE 28.571 203 125 5 5 195 127 321 3.39E-14 75.9 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8K0U4 CHOYP_HS12A.20.33 m.55554 sp HS12A_MOUSE 34.135 624 354 12 46 618 56 673 3.39E-110 348 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8ND56 CHOYP_LS14A.3.3 m.12695 sp LS14A_HUMAN 42.38 479 224 12 1 465 1 441 3.39E-74 245 LS14A_HUMAN reviewed Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) LSM14A C19orf13 FAM61A RAP55 RAP55A Homo sapiens (Human) 463 cytoplasmic mRNA processing body assembly [GO:0033962]; multicellular organism development [GO:0007275]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of translation [GO:0006417]; RIG-I signaling pathway [GO:0039529] GO:0000932; GO:0003690; GO:0003725; GO:0003727; GO:0005737; GO:0006417; GO:0007275; GO:0010494; GO:0033962; GO:0039529; GO:0043231; GO:0044822; GO:0060340 0 0 0 PF09532;PF12701; Q8STF0 CHOYP_CALM.33.50 m.49129 sp CALM_STRIE 61.538 156 58 1 6 161 1 154 3.39E-62 191 CALM_STRIE reviewed Calmodulin (CaM) 0 Strongylocentrotus intermedius (Sea urchin) 156 0 GO:0005509 0 0 0 PF13499; Q90600 CHOYP_RB.1.1 m.17702 sp RB_CHICK 37.244 878 438 26 31 839 38 871 3.39E-153 476 RB_CHICK reviewed Retinoblastoma-associated protein (p104) (pRb) (Rb) RB1 Gallus gallus (Chicken) 921 "apoptotic process [GO:0006915]; cell cycle [GO:0007049]; covalent chromatin modification [GO:0016569]; negative regulation of cell proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0003677; GO:0006351; GO:0006357; GO:0006915; GO:0007049; GO:0008285; GO:0016032; GO:0016569; GO:0035189; GO:0045892; GO:2000134 0 0 0 PF11934;PF01858;PF01857;PF08934; Q91974 CHOYP_IKBA.1.1 m.38917 sp IKBA_CHICK 38.776 147 86 3 151 294 90 235 3.39E-19 89 IKBA_CHICK reviewed NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (REL-associated protein pp40) NFKBIA IKBA Gallus gallus (Chicken) 318 regulation of fibroblast proliferation [GO:0048145] GO:0005737; GO:0048145 0 0 0 PF00023;PF12796; Q99K28 CHOYP_LOC100373141.1.1 m.11194 sp ARFG2_MOUSE 44.946 554 251 20 16 552 1 517 3.39E-135 405 ARFG2_MOUSE reviewed ADP-ribosylation factor GTPase-activating protein 2 (ARF GAP 2) (GTPase-activating protein ZNF289) (Zinc finger protein 289) Arfgap2 Zfp289 Znf289 Mus musculus (Mouse) 520 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0005096; GO:0005737; GO:0005794; GO:0005886; GO:0015031; GO:0016192; GO:0046872 0 0 0 PF01412; Q9CQR2 CHOYP_LOC100701551.1.7 m.3948 sp RS21_MOUSE 68.293 82 26 0 21 102 2 83 3.39E-37 123 RS21_MOUSE reviewed 40S ribosomal protein S21 Rps21 Mus musculus (Mouse) 83 "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; translation [GO:0006412]" GO:0000447; GO:0000461; GO:0003735; GO:0005737; GO:0006412; GO:0015935; GO:0022627; GO:0043022; GO:0044822; GO:0047485 0 0 0 PF01249; Q9JLJ4 CHOYP_ELOV4.3.3 m.64203 sp ELOV2_MOUSE 41.053 285 156 5 40 324 20 292 3.39E-67 215 ELOV2_MOUSE reviewed Elongation of very long chain fatty acids protein 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Very long chain 3-ketoacyl-CoA synthase 2) (Very long chain 3-oxoacyl-CoA synthase 2) Elovl2 Ssc2 Mus musculus (Mouse) 292 "fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]; very long-chain fatty acid metabolic process [GO:0000038]" GO:0000038; GO:0005783; GO:0005789; GO:0006636; GO:0009922; GO:0016021; GO:0016747; GO:0019367; GO:0034626; GO:0042761; GO:0102336; GO:0102337; GO:0102338 "PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:21106902}." 0 0 PF01151; Q9P0J1 CHOYP_PDP2.2.2 m.50974 sp PDP1_HUMAN 37.969 453 255 10 69 497 80 530 3.39E-88 283 PDP1_HUMAN reviewed "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1)" PDP1 PDP PPM2C Homo sapiens (Human) 537 peptidyl-threonine dephosphorylation [GO:0035970]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510] GO:0000287; GO:0004722; GO:0004724; GO:0004741; GO:0005509; GO:0005759; GO:0010510; GO:0035970 0 0 0 PF00481; Q9VCY8 CHOYP_DGRI_GH17396.1.1 m.62952 sp ADRL_DROME 65.823 316 108 0 79 394 120 435 3.39E-153 443 ADRL_DROME reviewed Adiponectin receptor protein AdipoR CG5315 Drosophila melanogaster (Fruit fly) 444 adiponectin-activated signaling pathway [GO:0033211]; fatty acid oxidation [GO:0019395]; female germ-line stem cell population maintenance [GO:0036099]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of insulin secretion [GO:0032024]; triglyceride homeostasis [GO:0070328] GO:0005886; GO:0009755; GO:0016021; GO:0019395; GO:0032024; GO:0033211; GO:0036099; GO:0042562; GO:0042593; GO:0046872; GO:0070328; GO:0097003 0 0 0 PF03006; A4IF63 CHOYP_BRAFLDRAFT_87280.1.1 m.64744 sp TRIM2_BOVIN 24.359 156 111 3 14 167 593 743 3.40E-06 53.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2X5V5 CHOYP_MSMB.2.5 m.22645 sp MSMB_DORPE 40.385 52 30 1 44 95 31 81 3.40E-06 45.1 MSMB_DORPE reviewed Beta-microseminoprotein (Beta-MSP) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 91 behavior [GO:0007610] GO:0005576; GO:0007610 0 0 0 0 P22935 CHOYP_RABP2.1.1 m.29597 sp RABP2_MOUSE 41.045 134 75 3 10 139 4 137 3.40E-26 99 RABP2_MOUSE reviewed Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II) Crabp2 Mus musculus (Mouse) 138 embryonic forelimb morphogenesis [GO:0035115]; positive regulation of collateral sprouting [GO:0048672]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; retinoic acid biosynthetic process [GO:0002138]; retinoic acid metabolic process [GO:0042573] GO:0001972; GO:0002138; GO:0005215; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0016918; GO:0019841; GO:0030332; GO:0035115; GO:0042573; GO:0048385; GO:0048672; GO:0070062 0 0 0 PF00061; P54120 CHOYP_GIMA4.4.7 m.42251 sp AIG1_ARATH 31.088 193 108 8 3 179 11 194 3.40E-11 65.9 AIG1_ARATH reviewed Protein AIG1 AIG1 At1g33960 T3M13.2 Arabidopsis thaliana (Mouse-ear cress) 353 response to bacterium [GO:0009617] GO:0005525; GO:0009617 0 0 0 PF04548; Q3SWX0 CHOYP_NIPA3.1.1 m.49253 sp NIPA2_BOVIN 57.143 315 134 1 34 347 9 323 3.40E-126 370 NIPA2_BOVIN reviewed Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog) NIPA2 Bos taurus (Bovine) 360 magnesium ion transport [GO:0015693] GO:0005769; GO:0005886; GO:0015095; GO:0015693; GO:0016021 0 0 0 PF05653; Q4ZJM9 CHOYP_C1QL2.24.32 m.47205 sp C1QL4_MOUSE 30.088 113 71 3 105 215 111 217 3.40E-06 50.1 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5R4R3 CHOYP_OGFD1.1.1 m.10563 sp OGFD1_PONAB 43.585 530 244 8 1 488 1 517 3.40E-142 422 OGFD1_PONAB reviewed Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) OGFOD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 542 cell proliferation [GO:0008283]; protein hydroxylation [GO:0018126]; regulation of translational termination [GO:0006449]; stress granule assembly [GO:0034063] GO:0005506; GO:0005634; GO:0006449; GO:0008283; GO:0010494; GO:0018126; GO:0031418; GO:0031543; GO:0031544; GO:0034063 0 0 0 PF10637; Q5R8X6 CHOYP_LOC100465916.1.1 m.44328 sp PLMN_PONAB 50 110 44 4 10 110 178 285 3.40E-26 104 PLMN_PONAB reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 810 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; Q5U317 CHOYP_LOC100217869.1.2 m.29774 sp FIP1_RAT 42.045 176 85 4 80 243 95 265 3.40E-26 115 FIP1_RAT reviewed Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1 protein) Fip1l1 Rattus norvegicus (Rat) 536 mRNA processing [GO:0006397] GO:0003723; GO:0005634; GO:0006397 0 0 0 PF05182; Q62158 CHOYP_LOC100376215.12.19 m.37307 sp TRI27_MOUSE 25.824 182 109 5 42 209 69 238 3.40E-09 61.2 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q62651 CHOYP_ECH1.1.1 m.29110 sp ECH1_RAT 59.93 287 111 2 4 287 42 327 3.40E-127 368 ECH1_RAT reviewed "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)" Ech1 Rattus norvegicus (Rat) 327 fatty acid beta-oxidation [GO:0006635]; fatty acid catabolic process [GO:0009062] GO:0005739; GO:0005777; GO:0006635; GO:0009062; GO:0016020; GO:0016853; GO:0070062 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00378; Q6GM78 CHOYP_LOC100373606.1.1 m.29757 sp ASGL1_XENLA 49.211 317 146 1 6 322 1 302 3.40E-92 280 ASGL1_XENLA reviewed Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] asrgl1 Xenopus laevis (African clawed frog) 309 asparagine catabolic process via L-aspartate [GO:0033345] GO:0004067; GO:0005737; GO:0008798; GO:0033345 0 0 0 PF01112; Q8BFR4 CHOYP_NEMVEDRAFT_V1G80221.1.1 m.12716 sp GNS_MOUSE 50.513 487 227 8 26 509 37 512 3.40E-170 494 GNS_MOUSE reviewed N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S) Gns Mus musculus (Mouse) 544 glycosaminoglycan metabolic process [GO:0030203] GO:0005764; GO:0008449; GO:0008484; GO:0030203; GO:0046872; GO:0070062 0 0 0 PF00884; Q8BP86 CHOYP_LOC100546924.2.2 m.58618 sp SNPC4_MOUSE 34.052 464 258 10 87 546 79 498 3.40E-65 245 SNPC4_MOUSE reviewed snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA-activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) Snapc4 Mus musculus (Mouse) 1333 "regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase III promoter [GO:0042796]; snRNA transcription from RNA polymerase II promoter [GO:0042795]" GO:0003677; GO:0006355; GO:0019185; GO:0042795; GO:0042796 0 0 0 0 Q8CCA0 CHOYP_DCNL4.1.2 m.36826 sp DCNL4_MOUSE 67.094 234 69 3 1 228 61 292 3.40E-111 323 DCNL4_MOUSE reviewed DCN1-like protein 4 (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4) Dcun1d4 Mus musculus (Mouse) 292 positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein neddylation [GO:0045116] GO:0000151; GO:0005634; GO:0031624; GO:0032182; GO:0045116; GO:0051443; GO:0097602 0 0 0 PF03556; Q8N3Y7 CHOYP_SDR16C5.1.1 m.7423 sp RDHE2_HUMAN 53.497 286 130 2 51 335 19 302 3.40E-110 326 RDHE2_HUMAN reviewed Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5) SDR16C5 RDHE2 Homo sapiens (Human) 309 detection of light stimulus involved in visual perception [GO:0050908]; keratinocyte proliferation [GO:0043616]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572] GO:0004745; GO:0005789; GO:0016021; GO:0042572; GO:0042574; GO:0043616; GO:0050908 PATHWAY: Cofactor metabolism; retinol metabolism. 0 0 PF00106; Q92847 CHOYP_BRAFLDRAFT_69423.2.2 m.49427 sp GHSR_HUMAN 26.941 219 130 10 40 243 84 287 3.40E-07 55.1 GHSR_HUMAN reviewed Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) 366 actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin stimulus [GO:0032869]; decidualization [GO:0046697]; G-protein coupled receptor signaling pathway [GO:0007186]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 biosynthetic process [GO:0045409]; negative regulation of tumor necrosis factor biosynthetic process [GO:0042536]; positive regulation of appetite [GO:0032100]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; regulation of hindgut contraction [GO:0043134]; regulation of synapse assembly [GO:0051963]; response to food [GO:0032094]; response to hormone [GO:0009725] GO:0001616; GO:0004930; GO:0005886; GO:0007186; GO:0008154; GO:0008343; GO:0009725; GO:0009755; GO:0009986; GO:0016021; GO:0016520; GO:0017046; GO:0030252; GO:0032094; GO:0032100; GO:0032691; GO:0032869; GO:0040018; GO:0042536; GO:0043005; GO:0043134; GO:0043568; GO:0045121; GO:0045409; GO:0045923; GO:0046676; GO:0046697; GO:0050728; GO:0051963 0 0 0 PF00001; Q95NI4 CHOYP_BRAFLDRAFT_115029.1.2 m.8365 sp CALM_HALOK 40.58 138 79 3 3 138 11 147 3.40E-25 96.7 CALM_HALOK reviewed Calmodulin (CaM) 0 Halichondria okadai (Marine sponge) (Reniera okadai) 149 0 GO:0005509 0 0 0 PF13499; Q95SX7 CHOYP_LOC764672.1.1 m.21244 sp RTBS_DROME 29.684 411 263 6 1 392 450 853 3.40E-45 174 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q9DBP0 CHOYP_NPT2B.1.2 m.57195 sp NPT2B_MOUSE 53.188 549 223 8 63 583 64 606 3.40E-178 525 NPT2B_MOUSE reviewed Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2) Slc34a2 Npt2b Mus musculus (Mouse) 697 cellular phosphate ion homeostasis [GO:0030643]; in utero embryonic development [GO:0001701]; phosphate ion transport [GO:0006817]; response to estrogen [GO:0043627] GO:0001701; GO:0005315; GO:0005436; GO:0005737; GO:0005903; GO:0006817; GO:0015321; GO:0016021; GO:0016324; GO:0030643; GO:0031402; GO:0031982; GO:0042301; GO:0043627 0 0 0 PF02690; Q9HCF6 CHOYP_TRPM8.5.5 m.63751 sp TRPM3_HUMAN 27.052 329 206 10 97 416 886 1189 3.40E-30 128 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9JLC8 CHOYP_NEMVEDRAFT_V1G247395.5.8 m.35014 sp SACS_MOUSE 23.659 820 524 28 16 760 3232 4024 3.40E-39 162 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9MYM7 CHOYP_LOC100869177.1.1 m.39445 sp B3GT1_PONPY 34.025 241 139 7 83 319 53 277 3.40E-34 132 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9Y5Y6 CHOYP_LOC100893967.1.1 m.16891 sp ST14_HUMAN 27.991 443 235 17 194 624 457 827 3.40E-30 130 ST14_HUMAN reviewed Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) ST14 PRSS14 SNC19 TADG15 Homo sapiens (Human) 855 epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; proteolysis [GO:0006508] GO:0001843; GO:0004252; GO:0005615; GO:0005886; GO:0005887; GO:0006508; GO:0008236; GO:0016323; GO:0019897; GO:0030216; GO:0060672; GO:0070062 0 0 cd00190; PF00431;PF00057;PF01390;PF00089; Q9Y7S2 CHOYP_CLUG_04850.3.4 m.27877 sp YQO3_SCHPO 29.545 132 91 1 26 155 129 260 3.40E-10 61.2 YQO3_SCHPO reviewed UPF0612 protein C569.003 SPCC569.03 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 375 0 GO:0005829 0 0 0 PF08593; D2GXS7 CHOYP_BRAFLDRAFT_241726.12.22 m.32674 sp TRIM2_AILME 20.37 270 174 7 28 269 488 744 3.41E-06 51.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_LOC100373444.32.79 m.32789 sp TRIM2_AILME 23.954 263 179 5 47 294 488 744 3.41E-12 70.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43301 CHOYP_HS12A.4.33 m.24987 sp HS12A_HUMAN 28.98 735 344 23 10 684 57 673 3.41E-78 266 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O60478 CHOYP_BRAFLDRAFT_203444.1.1 m.60156 sp G137B_HUMAN 47.23 343 170 5 24 359 15 353 3.41E-104 317 G137B_HUMAN reviewed Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein) GPR137B TM7SF1 Homo sapiens (Human) 399 0 GO:0005765; GO:0005887; GO:0016020 0 0 0 0 O93603 CHOYP_LOC100167215.1.1 m.39483 sp TRFR_CHICK 22.767 347 210 11 13 333 3 317 3.41E-06 52 TRFR_CHICK reviewed Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Gallus gallus (Chicken) 395 0 GO:0004997; GO:0005886; GO:0016021 0 0 0 PF00001; P16157 CHOYP_AAEL_AAEL014742.7.8 m.65269 sp ANK1_HUMAN 31.301 607 388 7 11 613 139 720 3.41E-77 271 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_LOC753709.21.44 m.39971 sp ANK1_HUMAN 32.44 709 439 29 108 790 79 773 3.41E-62 231 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P36241 CHOYP_LOC100206718.1.2 m.20884 sp RL19_DROME 75.385 195 48 0 6 200 1 195 3.41E-97 283 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P70549 CHOYP_LOC100371845.2.3 m.30117 sp NAC3_RAT 37.667 900 446 20 3 806 47 927 3.41E-179 541 NAC3_RAT reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Rattus norvegicus (Rat) 927 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005739; GO:0005741; GO:0005789; GO:0005874; GO:0005886; GO:0005887; GO:0006814; GO:0006851; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0016528; GO:0021537; GO:0030054; GO:0031594; GO:0042383; GO:0042552; GO:0042995; GO:0043025; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0071320; GO:0071456; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; P70582 CHOYP_NUP54.1.1 m.24886 sp NUP54_RAT 54.271 398 175 4 154 547 111 505 3.41E-145 431 NUP54_RAT reviewed Nuclear pore complex protein Nup54 (54 kDa nucleoporin) (Nucleoporin Nup54) Nup54 Rattus norvegicus (Rat) 510 mRNA transport [GO:0051028]; NLS-bearing protein import into nucleus [GO:0006607]; nuclear pore organization [GO:0006999]; nucleocytoplasmic transport [GO:0006913]; protein heterooligomerization [GO:0051291]; protein heterotetramerization [GO:0051290]; protein heterotrimerization [GO:0070208]; protein homooligomerization [GO:0051260]; protein targeting [GO:0006605]; protein targeting to nuclear inner membrane [GO:0036228]; regulation of protein import into nucleus [GO:0042306] GO:0005487; GO:0005635; GO:0005643; GO:0006605; GO:0006607; GO:0006913; GO:0006999; GO:0017056; GO:0031965; GO:0036228; GO:0042306; GO:0043234; GO:0044613; GO:0051028; GO:0051260; GO:0051290; GO:0051291; GO:0070208 0 0 0 PF13874; Q0P5F0 CHOYP_PPAL.2.2 m.32405 sp PPAL_BOVIN 40.051 392 212 9 48 434 8 381 3.41E-91 286 PPAL_BOVIN reviewed Lysosomal acid phosphatase (LAP) (EC 3.1.3.2) ACP2 Bos taurus (Bovine) 423 lysosome organization [GO:0007040]; skeletal system development [GO:0001501] GO:0001501; GO:0003993; GO:0005765; GO:0007040; GO:0016021; GO:0043202; GO:0070062 0 0 cd07061; PF00328; Q1EHB4 CHOYP_LOC582008.3.3 m.64466 sp SC5AC_HUMAN 35.029 511 297 11 2 509 97 575 3.41E-90 293 SC5AC_HUMAN reviewed Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) SLC5A12 SMCT2 Homo sapiens (Human) 618 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015129; GO:0015293; GO:0015355; GO:0016324; GO:0070062 0 0 0 PF00474; Q5AF03 CHOYP_LOC100199980.1.2 m.51259 sp HSP31_CANAL 33.193 238 133 7 3 222 2 231 3.41E-29 112 HSP31_CANAL reviewed Glyoxalase 3 (EC 4.2.1.130) (Glutathione-independent glyoxalase) GLX3 CaO19.251 CaO19.7882 orf19.251 orf19.7882 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 236 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243] GO:0019172; GO:0019243 0 0 0 PF01965; Q5TFE4 CHOYP_LOC100556034.1.2 m.13386 sp NT5D1_HUMAN 37.991 458 263 12 46 493 3 449 3.41E-89 283 NT5D1_HUMAN reviewed 5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-) NT5DC1 NT5C2L1 LP2642 Homo sapiens (Human) 455 0 GO:0008253; GO:0046872 0 0 0 PF05761; Q6MHJ5 CHOYP_LOC100888299.1.3 m.3738 sp PIF1_BDEBA 27.133 457 241 17 982 1423 51 430 3.41E-29 126 PIF1_BDEBA reviewed ATP-dependent DNA helicase pif1 (EC 3.6.4.12) pif1 Bd3546 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) 439 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] GO:0000723; GO:0003677; GO:0003678; GO:0005524; GO:0006281; GO:0006310 0 0 0 PF05970; Q6NSW5 CHOYP_BRAFLDRAFT_224716.1.2 m.41344 sp FA45B_HUMAN 47.55 347 176 4 32 375 14 357 3.41E-113 337 FA45B_HUMAN reviewed Putative protein FAM45B FAM45BP FAM45 HT011 Homo sapiens (Human) 357 0 0 0 0 0 0 Q6PDJ1 CHOYP_NEMVEDRAFT_V1G238894.1.11 m.34327 sp CAHD1_MOUSE 26.355 1070 677 40 26 1026 59 1086 3.41E-90 320 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6PFY8 CHOYP_TRIM45.9.9 m.42406 sp TRI45_MOUSE 28.652 178 111 9 4 167 127 302 3.41E-07 52.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7I3 CHOYP_Y004.1.1 m.30757 sp Y041_OSHVF 25.967 181 116 6 8 184 415 581 3.41E-13 71.2 Y041_OSHVF reviewed Uncharacterized protein ORF41 ORF41 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 972 0 GO:0016021; GO:0033644 0 0 0 0 Q70E20 CHOYP_LOC101068378.2.3 m.20091 sp SNED1_MOUSE 31.2 125 75 4 800 921 72 188 3.41E-11 71.6 SNED1_MOUSE reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) 1403 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q7RTS6 CHOYP_LOC100869441.1.2 m.45217 sp OTOP2_HUMAN 22.547 479 295 13 473 890 96 559 3.41E-22 105 OTOP2_HUMAN reviewed Otopetrin-2 OTOP2 Homo sapiens (Human) 562 0 GO:0016021 0 0 0 PF03189; Q7YU29 CHOYP_UTRO.1.1 m.19749 sp DMDE_DROME 36.175 481 232 13 2 419 424 892 3.41E-80 275 DMDE_DROME reviewed "Dystrophin, isoform E (Protein detached)" Dys det CG34157 Drosophila melanogaster (Fruit fly) 1051 establishment of cell polarity [GO:0030010]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; neuromuscular synaptic transmission [GO:0007274]; regulation of neurotransmitter secretion [GO:0046928]; regulation of short-term neuronal synaptic plasticity [GO:0048172] GO:0003779; GO:0005198; GO:0005737; GO:0005856; GO:0005938; GO:0007274; GO:0007474; GO:0007517; GO:0008092; GO:0008270; GO:0008307; GO:0008586; GO:0016010; GO:0030010; GO:0042383; GO:0045202; GO:0046716; GO:0046928; GO:0048172; GO:0050699 0 0 0 PF09068;PF09069;PF00569; Q8C6U2 CHOYP_LOC101063557.1.1 m.16092 sp PQLC3_MOUSE 34.896 192 112 5 21 208 20 202 3.41E-33 120 PQLC3_MOUSE reviewed PQ-loop repeat-containing protein 3 Pqlc3 Mus musculus (Mouse) 202 dolichol-linked oligosaccharide biosynthetic process [GO:0006488] GO:0006488; GO:0016021 0 0 0 PF04193; Q8CE72 CHOYP_BRAFLDRAFT_117629.1.2 m.10909 sp CE042_MOUSE 28.009 864 515 28 18 838 574 1373 3.41E-79 297 CE042_MOUSE reviewed Uncharacterized protein C5orf42 homolog 0 Mus musculus (Mouse) 3214 cardiac septum development [GO:0003279]; cerebellum development [GO:0021549]; cilium assembly [GO:0042384]; coronary vasculature development [GO:0060976]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; heart development [GO:0007507]; kidney development [GO:0001822]; palate development [GO:0060021]; protein localization to ciliary transition zone [GO:1904491]; ventricular septum development [GO:0003281] GO:0001736; GO:0001822; GO:0003279; GO:0003281; GO:0007507; GO:0016021; GO:0021549; GO:0035869; GO:0042384; GO:0042733; GO:0060021; GO:0060976; GO:1904491 0 0 0 PF15392; Q8MPM1 CHOYP_LOC100642024.1.2 m.38402 sp GELS2_LUMTE 57.297 370 151 4 1 367 1 366 3.41E-149 428 GELS2_LUMTE reviewed Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) 366 actin filament capping [GO:0051693] GO:0005737; GO:0005856; GO:0051693 0 0 0 PF00626; Q8VED2 CHOYP_BLOC1S4.1.1 m.22903 sp BL1S4_MOUSE 36.719 128 78 2 51 175 80 207 3.41E-26 102 BL1S4_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog) Bloc1s4 Cno Mus musculus (Mouse) 215 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; melanosome organization [GO:0032438]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; platelet aggregation [GO:0070527] GO:0005737; GO:0008089; GO:0031083; GO:0031175; GO:0032438; GO:0048490; GO:0050885; GO:0070527; GO:1904115 0 0 0 0 Q91WQ5 CHOYP_BRAFLDRAFT_274913.1.1 m.65139 sp TAF5L_MOUSE 42.564 585 328 4 29 609 1 581 3.41E-163 482 TAF5L_MOUSE reviewed TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (PCAF-associated factor 65 beta) (PAF65-beta) Taf5l Paf65b Mus musculus (Mouse) 589 "histone H3 acetylation [GO:0043966]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0004402; GO:0006351; GO:0006355; GO:0030914; GO:0033276; GO:0043966 0 0 cd08044; PF04494;PF00400; Q9D8N3 CHOYP_LOC100741906.1.1 m.66501 sp TM86A_MOUSE 46.154 234 121 3 11 240 1 233 3.41E-63 200 TM86A_MOUSE reviewed Lysoplasmalogenase-like protein TMEM86A (Transmembrane protein 86A) Tmem86a Mus musculus (Mouse) 241 0 GO:0016021 0 0 0 PF07947; Q9H8W5 CHOYP_LOC100011500.1.2 m.39287 sp TRI45_HUMAN 32.71 107 62 3 36 132 116 222 3.41E-06 49.3 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9HCC6 CHOYP_HES1.3.3 m.43104 sp HES4_HUMAN 48.387 124 61 2 2 123 24 146 3.41E-33 126 HES4_HUMAN reviewed Transcription factor HES-4 (hHES4) (Class B basic helix-loop-helix protein 42) (bHLHb42) (Hairy and enhancer of split 4) (bHLH factor Hes4) HES4 BHLHB42 Homo sapiens (Human) 221 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007399; GO:0008134; GO:0030154 0 0 0 PF07527;PF00010; Q9JLC8 CHOYP_NEMVEDRAFT_V1G247395.8.8 m.62523 sp SACS_MOUSE 21.9 1274 846 39 52 1221 3350 4578 3.41E-59 228 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9NZF1 CHOYP_NEMVEDRAFT_V1G205075.2.4 m.15400 sp PLAC8_HUMAN 33.621 116 60 5 55 164 7 111 3.41E-08 52.4 PLAC8_HUMAN reviewed Placenta-specific gene 8 protein (Protein C15) PLAC8 BM-004 Homo sapiens (Human) 115 brown fat cell differentiation [GO:0050873]; defense response to bacterium [GO:0042742]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cold [GO:0009409] GO:0003682; GO:0008284; GO:0009409; GO:0040015; GO:0042742; GO:0043066; GO:0045944; GO:0050873 0 0 0 PF04749; A0JPI9 CHOYP_LOC100005101.1.1 m.21865 sp LR74A_RAT 32.869 359 232 7 54 408 19 372 3.42E-49 179 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; B2RXS4 CHOYP_DGRI_GH23973.1.1 m.45549 sp PLXB2_MOUSE 28.431 102 73 0 1 102 458 559 3.42E-16 76.6 PLXB2_MOUSE reviewed Plexin-B2 Plxnb2 Mus musculus (Mouse) 1842 brain development [GO:0007420]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0001843; GO:0001932; GO:0002116; GO:0005887; GO:0007162; GO:0007405; GO:0007420; GO:0008360; GO:0009986; GO:0017154; GO:0043087; GO:0050772; GO:0070062; GO:0071526; GO:1902287; GO:2001222 0 0 0 PF08337;PF01437;PF01403;PF01833; O15050 CHOYP_TRANK1.4.9 m.21916 sp TRNK1_HUMAN 28.877 187 120 6 405 584 423 603 3.42E-13 77.4 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O62640 CHOYP_TIAP2.10.13 m.55072 sp PIAP_PIG 34.386 285 172 4 225 506 86 358 3.42E-54 189 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P13993 CHOYP_SMP_014610.1.1 m.28152 sp PRP2_SOYBN 52.198 182 86 1 184 365 28 208 3.42E-19 90.1 PRP2_SOYBN reviewed Repetitive proline-rich cell wall protein 2 PRP2 RPRP3 Glycine max (Soybean) (Glycine hispida) 230 multicellular organism development [GO:0007275] GO:0005199; GO:0005576; GO:0005618; GO:0007275 0 0 0 PF02095; P18503 CHOYP_BRAFLDRAFT_76550.15.21 m.63277 sp CAS4_EPHMU 34.4 125 60 5 78 198 207 313 3.42E-08 57 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P47838 CHOYP_RS6.4.12 m.13759 sp RS6_CHICK 85.517 145 20 1 1 145 32 175 3.42E-87 258 RS6_CHICK reviewed 40S ribosomal protein S6 RPS6 Gallus gallus (Chicken) 249 glucose homeostasis [GO:0042593]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0006364; GO:0006412; GO:0022627; GO:0042274; GO:0042593 0 0 0 PF01092; P53505 CHOYP_ACT3.2.3 m.23309 sp ACT5_XENLA 96.774 186 6 0 1 186 191 376 3.42E-133 380 ACT5_XENLA reviewed "Actin, cytoplasmic type 5" 0 Xenopus laevis (African clawed frog) 376 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; P61354 CHOYP_LOC100373506.4.8 m.35530 sp RL27_RAT 82.353 136 24 0 59 194 1 136 3.42E-79 235 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; P83425 CHOYP_C1QT5.1.1 m.66198 sp HIP_MYTED 28.846 156 103 4 23 174 37 188 3.42E-10 60.5 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P98073 CHOYP_BRAFLDRAFT_277744.1.2 m.5416 sp ENTK_HUMAN 32.558 258 162 6 21 275 768 1016 3.42E-41 154 ENTK_HUMAN reviewed Enteropeptidase (EC 3.4.21.9) (Enterokinase) (Serine protease 7) (Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain] TMPRSS15 ENTK PRSS7 Homo sapiens (Human) 1019 0 GO:0004252; GO:0005044; GO:0005903; GO:0016021 0 0 cd06263;cd00190; PF00431;PF00057;PF00629;PF01390;PF15494;PF00089; Q0E908 CHOYP_CRE-LTD-1.1.1 m.33824 sp HIL_DROME 24.645 422 272 11 157 564 388 777 3.42E-27 121 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q1JQ66 CHOYP_S35E3.1.1 m.8940 sp S35E3_DANRE 61.111 288 111 1 12 299 17 303 3.42E-127 368 S35E3_DANRE reviewed Solute carrier family 35 member E3 slc35e3 Danio rerio (Zebrafish) (Brachydanio rerio) 313 0 GO:0005338; GO:0016021 0 0 0 PF03151; Q1ZXD6 CHOYP_BRAFLDRAFT_129004.1.15 m.21108 sp ROCO5_DICDI 22.571 350 197 12 378 707 1282 1577 3.42E-10 68.6 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q5DTT8 CHOYP_LOC100708199.3.6 m.23799 sp PNMA5_MOUSE 25.362 138 96 3 63 193 157 294 3.42E-06 52.8 PNMA5_MOUSE reviewed Paraneoplastic antigen-like protein 5 Pnma5 Kiaa1934 Mus musculus (Mouse) 618 0 GO:0042802 0 0 0 PF14893; Q66PY1 CHOYP_EIN_413630.1.1 m.2687 sp SCUB3_MOUSE 32.11 109 73 1 22 129 691 799 3.42E-11 62.4 SCUB3_MOUSE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 3" Scube3 Mus musculus (Mouse) 993 protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] GO:0005509; GO:0005576; GO:0009986; GO:0051260; GO:0051291 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q689Z5 CHOYP_NEMVEDRAFT_V1G241547.1.1 m.12422 sp SBNO1_MOUSE 37.975 237 129 6 2 223 1067 1300 3.42E-36 139 SBNO1_MOUSE reviewed Protein strawberry notch homolog 1 (mSno1) Sbno1 Sno1 Mus musculus (Mouse) 1390 "regulation of transcription, DNA-templated [GO:0006355]" GO:0006355 0 0 0 PF13871; Q6IR76 CHOYP_LOC100161187.1.1 m.16758 sp TMM19_XENLA 47.159 176 90 2 1 176 161 333 3.42E-51 170 TMM19_XENLA reviewed Transmembrane protein 19 tmem19 Xenopus laevis (African clawed frog) 336 0 GO:0016021 0 0 0 PF01940; Q86WI1 CHOYP_PKHL1.1.3 m.15959 sp PKHL1_HUMAN 37.544 285 167 6 1 284 1657 1931 3.42E-42 157 PKHL1_HUMAN reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) 4243 immune response [GO:0006955] GO:0004872; GO:0005615; GO:0005829; GO:0006955; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8K0U4 CHOYP_HSPA12A.13.27 m.36944 sp HS12A_MOUSE 30.818 636 368 17 13 594 57 674 3.42E-86 285 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8WZ42 CHOYP_SI_CH73-177H5.3.1.1 m.60565 sp TITIN_HUMAN 25.143 350 214 12 14 353 7158 7469 3.42E-11 68.6 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q99549 CHOYP_LOC100372844.1.2 m.39840 sp MPP8_HUMAN 36.391 327 202 3 512 833 534 859 3.42E-58 217 MPP8_HUMAN reviewed M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) MPHOSPH8 MPP8 Homo sapiens (Human) 860 "negative regulation of transcription, DNA-templated [GO:0045892]; regulation of DNA methylation [GO:0044030]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000788; GO:0004842; GO:0005634; GO:0005720; GO:0005730; GO:0005737; GO:0005886; GO:0006351; GO:0031625; GO:0035064; GO:0044030; GO:0045892; GO:0070062 0 0 0 PF12796;PF00385; Q9HBK9 CHOYP_BRAFLDRAFT_124020.1.1 m.22574 sp AS3MT_HUMAN 49.346 306 144 3 3 301 74 375 3.42E-100 301 AS3MT_HUMAN reviewed Arsenite methyltransferase (EC 2.1.1.137) (Methylarsonite methyltransferase) (S-adenosyl-L-methionine:arsenic(III) methyltransferase) AS3MT CYT19 Homo sapiens (Human) 375 arsonoacetate metabolic process [GO:0018872]; methylation [GO:0032259]; toxin metabolic process [GO:0009404] GO:0005737; GO:0005739; GO:0005829; GO:0008757; GO:0009404; GO:0018872; GO:0030791; GO:0030792; GO:0032259 0 0 0 PF13847; Q9VRJ2 CHOYP_LOC100899229.1.1 m.12157 sp FITM_DROME 31.438 299 183 4 1 283 24 316 3.42E-54 185 FITM_DROME reviewed FIT family protein CG10671 CG10671 Drosophila melanogaster (Fruit fly) 423 lipid particle organization [GO:0034389]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654] GO:0005789; GO:0008654; GO:0019915; GO:0030176; GO:0034389 0 0 0 PF10261; Q9Y6U7 CHOYP_LOC101061979.1.1 m.42607 sp RN215_HUMAN 31.31 313 188 11 78 373 68 370 3.42E-38 144 RN215_HUMAN reviewed RING finger protein 215 RNF215 Homo sapiens (Human) 377 0 GO:0008270; GO:0016021 0 0 0 PF13639; A0MTA1 CHOYP_LOC100373457.1.1 m.27685 sp APEX1_DANRE 55.556 270 114 5 148 413 42 309 3.43E-105 316 APEX1_DANRE reviewed DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (zAP1) apex1 apex1a apex1b si:ch211-214j24.12 zgc:66204 Danio rerio (Zebrafish) (Brachydanio rerio) 310 base-excision repair [GO:0006284]; DNA demethylation [GO:0080111]; heart contraction [GO:0060047]; heart looping [GO:0001947]; negative regulation of apoptotic process [GO:0043066]; positive regulation of gene expression [GO:0010628] GO:0001947; GO:0003677; GO:0003723; GO:0003906; GO:0005634; GO:0005730; GO:0005739; GO:0005783; GO:0006284; GO:0008311; GO:0010628; GO:0016607; GO:0043066; GO:0046872; GO:0060047; GO:0080111 0 0 0 PF03372; A5D6U8 CHOYP_LOC100366862.1.1 m.62455 sp ACP7_DANRE 56.934 411 170 4 24 429 31 439 3.43E-171 489 ACP7_DANRE reviewed Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form) acp7 papl zgc:162913 Danio rerio (Zebrafish) (Brachydanio rerio) 443 0 GO:0003993; GO:0005576; GO:0046872 0 0 0 PF00149;PF14008;PF16656; G5ED84 CHOYP_BACH1.7.17 m.12237 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 3.43E-11 70.1 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O00468 CHOYP_PHUM_PHUM498630.3.3 m.64363 sp AGRIN_HUMAN 29.481 424 209 15 1 354 591 994 3.43E-33 140 AGRIN_HUMAN reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Homo sapiens (Human) 2067 clustering of voltage-gated sodium channels [GO:0045162]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0001523; GO:0002162; GO:0005200; GO:0005509; GO:0005576; GO:0005605; GO:0005737; GO:0005796; GO:0005886; GO:0006024; GO:0006027; GO:0007165; GO:0007213; GO:0016021; GO:0030054; GO:0030198; GO:0030203; GO:0031012; GO:0033691; GO:0035374; GO:0043113; GO:0043202; GO:0043236; GO:0043395; GO:0043547; GO:0045162; GO:0045202; GO:0045887; GO:0045944; GO:0050808; GO:0051491; GO:0070062 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF03146;PF01390; O13997 CHOYP_LOC100124265.1.1 m.15557 sp YIH1_SCHPO 36.29 124 75 2 305 424 135 258 3.43E-15 79 YIH1_SCHPO reviewed Protein IMPACT homolog yih1 SPAC27E2.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 280 cellular response to acidic pH [GO:0071468]; cellular response to amino acid starvation [GO:0034198]; cellular response to benomyl [GO:0072755]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of cell death [GO:0060548]; regulation of cytoplasmic translation in response to stress [GO:1990497] GO:0005634; GO:0005737; GO:0034198; GO:0060548; GO:0070301; GO:0071468; GO:0072755; GO:1990497 0 0 0 PF05773;PF01205; O15553 CHOYP_TRI23.2.7 m.23115 sp MEFV_HUMAN 38.333 60 37 0 35 94 373 432 3.43E-07 52 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; O77302 CHOYP_RS10.5.5 m.45749 sp RS10_LUMRU 77.922 154 30 3 28 180 1 151 3.43E-80 238 RS10_LUMRU reviewed 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) 156 0 GO:0005840 0 0 0 PF03501; O95236 CHOYP_contig_032748 m.37415 sp APOL3_HUMAN 26.577 222 113 6 855 1047 177 377 3.43E-06 54.3 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P10079 CHOYP_LOC100634060.24.37 m.51170 sp FBP1_STRPU 56.051 157 69 0 1 157 395 551 3.43E-47 166 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P19623 CHOYP_LOC100370747.1.1 m.28315 sp SPEE_HUMAN 70.833 288 84 0 3 290 15 302 3.43E-158 446 SPEE_HUMAN reviewed Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) SRM SPS1 SRML1 Homo sapiens (Human) 302 polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295] GO:0004766; GO:0005829; GO:0006595; GO:0008295; GO:0042803 PATHWAY: Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. 0 0 0 P24528 CHOYP_LOC100905520.1.1 m.49146 sp MGMT_RAT 37.791 172 102 3 16 186 11 178 3.43E-35 125 MGMT_RAT reviewed Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) Mgmt Rattus norvegicus (Rat) 209 cellular response to DNA damage stimulus [GO:0006974]; cellular response to ionizing radiation [GO:0071479]; cellular response to organic cyclic compound [GO:0071407]; cellular response to oxidative stress [GO:0034599]; DNA dealkylation involved in DNA repair [GO:0006307]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell death [GO:0060548]; positive regulation of DNA repair [GO:0045739]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636] GO:0003684; GO:0003908; GO:0005509; GO:0005634; GO:0005654; GO:0006307; GO:0006974; GO:0009636; GO:0014070; GO:0016020; GO:0034599; GO:0042493; GO:0043281; GO:0045471; GO:0045739; GO:0051593; GO:0060548; GO:0060644; GO:0071407; GO:0071479 0 0 cd06445; PF01035;PF02870; P41596 CHOYP_LOC660195.1.1 m.31306 sp DOPR1_DROME 50.72 347 137 7 29 343 117 461 3.43E-107 328 DOPR1_DROME reviewed Dopamine receptor 1 (D-DOP1) (DmDop1) (dDA1) (Dopamine 1-like receptor 1) Dop1R1 DopR DopR1 DopR35EF CG9652 Drosophila melanogaster (Fruit fly) 511 "adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; associative learning [GO:0008306]; cellular response to sucrose stimulus [GO:0071329]; dopamine receptor signaling pathway [GO:0007212]; learning [GO:0007612]; memory [GO:0007613]; olfactory learning [GO:0008355]; regulation of olfactory learning [GO:0090328]; regulation of presynaptic cytosolic calcium ion concentration [GO:0099509]; response to odorant [GO:1990834]; response to starvation [GO:0042594]; response to sucrose [GO:0009744]; synaptic transmission, dopaminergic [GO:0001963]; thermosensory behavior [GO:0040040]; thermotaxis [GO:0043052]; visual learning [GO:0008542]" GO:0001588; GO:0001963; GO:0004930; GO:0004952; GO:0005887; GO:0007191; GO:0007212; GO:0007612; GO:0007613; GO:0008306; GO:0008355; GO:0008542; GO:0009744; GO:0016021; GO:0035240; GO:0040040; GO:0042594; GO:0043052; GO:0071329; GO:0090328; GO:0098793; GO:0099509; GO:1990834 0 0 0 PF00001; P53466 CHOYP_ACTA.2.2 m.43373 sp ACT2_LYTPI 50.769 65 25 2 19 83 279 336 3.43E-12 63.9 ACT2_LYTPI reviewed "Actin, cytoskeletal 2 (LPC2)" 0 Lytechinus pictus (Painted sea urchin) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P56276 CHOYP_TSP_09716.2.2 m.31454 sp MYLK_MELGA 39.785 93 54 2 150 241 42 133 3.43E-15 74.3 MYLK_MELGA reviewed Telokin 0 Meleagris gallopavo (Common turkey) 154 0 0 0 0 0 PF07679; P62840 CHOYP_PHUM_PHUM044580.1.1 m.11799 sp UB2D2_XENLA 50 144 72 0 238 381 4 147 3.43E-44 153 UB2D2_XENLA reviewed Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein 4) (xUBC4) (Ubiquitin carrier protein D2) (Ubiquitin-protein ligase D2) ube2d2 ubc4 ube2d3.1 Xenopus laevis (African clawed frog) 147 protein ubiquitination [GO:0016567] GO:0005524; GO:0016567; GO:0016740 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q0VB26 CHOYP_BRAFLDRAFT_117083.3.3 m.59001 sp TEX26_MOUSE 23.377 231 174 3 125 354 49 277 3.43E-12 70.5 TEX26_MOUSE reviewed Testis-expressed sequence 26 protein Tex26 Mus musculus (Mouse) 296 0 0 0 0 0 0 Q0VFL3 CHOYP_KHDR1.1.1 m.8878 sp KHDR2_XENTR 43.678 348 160 15 8 330 7 343 3.43E-72 230 KHDR2_XENTR reviewed "KH domain-containing, RNA-binding, signal transduction-associated protein 2" khdrbs2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 345 "mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003723; GO:0005634; GO:0006351; GO:0006355; GO:0006397 0 0 0 PF00013;PF16274;PF16568; Q12955 CHOYP_LOC754035.4.6 m.44578 sp ANK3_HUMAN 29.976 417 266 7 87 500 297 690 3.43E-36 147 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q13797 CHOYP_ITA9.2.2 m.48666 sp ITA9_HUMAN 32.243 214 120 8 20 227 29 223 3.43E-25 107 ITA9_HUMAN reviewed Integrin alpha-9 (Integrin alpha-RLC) ITGA9 Homo sapiens (Human) 1035 cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; integrin-mediated signaling pathway [GO:0007229]; neutrophil chemotaxis [GO:0030593]; wound healing [GO:0042060] GO:0005886; GO:0007155; GO:0007229; GO:0008305; GO:0009925; GO:0030198; GO:0030593; GO:0034679; GO:0042060; GO:0046872 0 0 0 PF01839;PF08441; Q5REW9 CHOYP_ANKRD27.1.1 m.12550 sp ANR27_PONAB 35.268 913 546 19 1 900 1 881 3.43E-157 498 ANR27_PONAB reviewed Ankyrin repeat domain-containing protein 27 ANKRD27 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1050 protein transport [GO:0015031] GO:0005764; GO:0005769; GO:0005770; GO:0005886; GO:0015031; GO:0030659; GO:0042470 0 0 0 PF12796;PF02204; Q5TGI4 CHOYP_LOC101164614.1.2 m.27571 sp SAMD5_HUMAN 42.675 157 84 3 1 155 1 153 3.43E-32 127 SAMD5_HUMAN reviewed Sterile alpha motif domain-containing protein 5 (SAM domain-containing protein 5) SAMD5 SAMDC1 Homo sapiens (Human) 173 0 0 0 0 0 PF00536; Q5UPG7 CHOYP_V234.1.1 m.57347 sp YL091_MIMIV 29.371 143 88 4 56 188 273 412 3.43E-08 59.3 YL091_MIMIV reviewed Putative ankyrin repeat protein L91 MIMI_L91 Acanthamoeba polyphaga mimivirus (APMV) 642 0 0 0 0 0 PF00023;PF12796; Q6GLJ1 CHOYP_LOC592989.1.1 m.27434 sp BTBDH_XENLA 28.873 284 178 7 21 294 39 308 3.43E-30 124 BTBDH_XENLA reviewed BTB/POZ domain-containing protein 17 btbd17 Xenopus laevis (African clawed frog) 470 0 GO:0005576 0 0 0 PF07707;PF00651; Q6QM28 CHOYP_LOC100533225.2.2 m.59327 sp SYN_HELPO 43.478 207 93 3 1 192 299 496 3.43E-41 148 SYN_HELPO reviewed Synapsin (helSyn) SYN Helix pomatia (Roman snail) (Edible snail) 496 neurotransmitter secretion [GO:0007269] GO:0003824; GO:0005524; GO:0007269; GO:0008021; GO:0030054; GO:0042995; GO:0046872 0 0 0 PF02078;PF02750; Q6YP21 CHOYP_CCBL2.1.1 m.43745 sp KAT3_HUMAN 46.809 423 217 4 4 423 36 453 3.43E-133 393 KAT3_HUMAN reviewed Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) KYAT3 CCBL2 KAT3 Homo sapiens (Human) 454 2-oxoglutarate metabolic process [GO:0006103]; biosynthetic process [GO:0009058]; cellular amino acid metabolic process [GO:0006520]; kynurenine metabolic process [GO:0070189] GO:0005739; GO:0006103; GO:0006520; GO:0009058; GO:0016212; GO:0030170; GO:0044822; GO:0047315; GO:0047804; GO:0070189 0 0 0 PF00155; Q8C1A9 CHOYP_LOC100708752.1.1 m.15631 sp ABD18_MOUSE 39.696 461 239 7 1 427 3 458 3.43E-112 340 ABD18_MOUSE reviewed Protein ABHD18 (Alpha/beta hydrolase domain-containing protein 18) (Abhydrolase domain-containing protein 18) Abhd18 Mus musculus (Mouse) 464 0 GO:0005576 0 0 0 PF09752; Q8C6L5 CHOYP_NEMVEDRAFT_V1G218264.9.14 m.34647 sp CGAS_MOUSE 26.144 153 99 3 196 334 328 480 3.43E-06 53.9 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8VHZ8 CHOYP_LOC660769.1.1 m.66148 sp DSCAM_RAT 31.683 101 67 1 28 126 219 319 3.43E-09 57.8 DSCAM_RAT reviewed Down syndrome cell adhesion molecule homolog Dscam Rattus norvegicus (Rat) 2013 camera-type eye photoreceptor cell differentiation [GO:0060219]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of phosphorylation [GO:0042327]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] GO:0005886; GO:0005887; GO:0007156; GO:0007162; GO:0007416; GO:0010842; GO:0030054; GO:0030424; GO:0030426; GO:0042327; GO:0045202; GO:0048842; GO:0060219; GO:0070593 0 0 0 PF00041;PF07679; Q96DR7 CHOYP_ISCW_ISCW001487.1.2 m.20961 sp ARHGQ_HUMAN 41.079 482 247 7 1155 1629 414 865 3.43E-114 386 ARHGQ_HUMAN reviewed Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) ARHGEF26 SGEF HMFN1864 Homo sapiens (Human) 871 endothelial cell morphogenesis [GO:0001886]; regulation of Rho protein signal transduction [GO:0035023]; ruffle assembly [GO:0097178] GO:0001726; GO:0001886; GO:0005089; GO:0035023; GO:0097178 0 0 0 PF00621;PF14604; Q9ESN6 CHOYP_contig_007467 m.8633 sp TRIM2_MOUSE 26.609 233 133 9 321 540 535 742 3.43E-08 60.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GL65 CHOYP_TLR13.5.5 m.41200 sp TLR4_BOVIN 25.349 430 287 14 434 855 413 816 3.43E-26 119 TLR4_BOVIN reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Bos taurus (Bovine) 841 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0001530; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005887; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13516;PF13855;PF01582; Q9UBC3 CHOYP_LOC101175080.2.2 m.60659 sp DNM3B_HUMAN 32.248 645 368 19 150 747 176 798 3.43E-97 323 DNM3B_HUMAN reviewed DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) DNMT3B Homo sapiens (Human) 853 "cellular response to dexamethasone stimulus [GO:0071549]; cellular response to hyperoxia [GO:0071455]; DNA methylation [GO:0006306]; DNA methylation on cytosine within a CG sequence [GO:0010424]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of histone H3-K9 methylation [GO:0051573]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of neuron differentiation [GO:0045666]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethioninamine metabolic process [GO:0046499]" GO:0000122; GO:0001666; GO:0003682; GO:0003714; GO:0003886; GO:0005634; GO:0005654; GO:0005737; GO:0006306; GO:0009008; GO:0009636; GO:0010212; GO:0010424; GO:0010628; GO:0014823; GO:0031000; GO:0032355; GO:0033189; GO:0042220; GO:0042493; GO:0043231; GO:0045322; GO:0045666; GO:0045814; GO:0046498; GO:0046499; GO:0046872; GO:0051571; GO:0051573; GO:0051718; GO:0071455; GO:0071549 0 0 0 PF00145;PF00855; Q9VCA8 CHOYP_LOC100640442.1.10 m.12475 sp ANKHM_DROME 32.941 340 195 11 187 513 588 907 3.43E-34 141 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9XZC0 CHOYP_TVAG_169080.1.2 m.54485 sp LCTA_LATTR 34.228 149 80 3 571 719 698 828 3.43E-14 80.5 LCTA_LATTR reviewed Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1) (Fragment) 0 Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) 1413 exocytosis [GO:0006887] GO:0005576; GO:0006887; GO:0016021; GO:0072556 0 0 0 PF12796;PF13606; Q9Y2C9 CHOYP_TLR1.1.3 m.1564 sp TLR6_HUMAN 29.126 309 192 9 300 602 475 762 3.43E-28 124 TLR6_HUMAN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) 796 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0038124; GO:0042088; GO:0042496; GO:0042742; GO:0043123; GO:0043507; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; A6NNF4 CHOYP_LOC571721.3.3 m.61926 sp ZN726_HUMAN 28.926 605 371 14 593 1193 156 705 3.44E-54 206 ZN726_HUMAN reviewed Zinc finger protein 726 ZNF726 Homo sapiens (Human) 738 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; O00468 CHOYP_LOC101156494.1.1 m.4227 sp AGRIN_HUMAN 31.72 558 326 16 60 578 44 585 3.44E-61 224 AGRIN_HUMAN reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] AGRN AGRIN Homo sapiens (Human) 2067 clustering of voltage-gated sodium channels [GO:0045162]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0001523; GO:0002162; GO:0005200; GO:0005509; GO:0005576; GO:0005605; GO:0005737; GO:0005796; GO:0005886; GO:0006024; GO:0006027; GO:0007165; GO:0007213; GO:0016021; GO:0030054; GO:0030198; GO:0030203; GO:0031012; GO:0033691; GO:0035374; GO:0043113; GO:0043202; GO:0043236; GO:0043395; GO:0043547; GO:0045162; GO:0045202; GO:0045887; GO:0045944; GO:0050808; GO:0051491; GO:0070062 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF03146;PF01390; O15990 CHOYP_KARG.11.11 m.50800 sp KARG_LIOJA 66.667 261 86 1 26 285 1 261 3.44E-126 366 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; P45962 CHOYP_BRAFLDRAFT_118210.1.1 m.51280 sp KLP3_CAEEL 42.394 401 210 5 419 807 174 565 3.44E-91 302 KLP3_CAEEL reviewed Kinesin-like protein klp-3 klp-3 T09A5.2 Caenorhabditis elegans 598 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018]; neurogenesis [GO:0022008] GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0008574; GO:0022008; GO:0030030 0 0 0 PF00225; P55210 CHOYP_CASP7.5.23 m.12847 sp CASP7_HUMAN 26.857 175 106 5 151 319 141 299 3.44E-06 51.6 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P58340 CHOYP_BRAFLDRAFT_127486.1.1 m.57687 sp MLF1_HUMAN 42.029 207 104 7 34 234 4 200 3.44E-40 143 MLF1_HUMAN reviewed Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) MLF1 Homo sapiens (Human) 268 "cell cycle arrest [GO:0007050]; myeloid progenitor cell differentiation [GO:0002318]; transcription, DNA-templated [GO:0006351]" GO:0002318; GO:0003677; GO:0005634; GO:0005737; GO:0006351; GO:0007050; GO:0019904 0 0 0 PF10248; P84817 CHOYP_LOC100367718.1.1 m.8839 sp FIS1_RAT 52 150 70 2 1 149 1 149 3.44E-49 158 FIS1_RAT reviewed Mitochondrial fission 1 protein (FIS1 homolog) (rFis1) (Tetratricopeptide repeat protein 11) (TPR repeat protein 11) Fis1 Ttc11 Rattus norvegicus (Rat) 152 calcium-mediated signaling using intracellular calcium source [GO:0035584]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; mitophagy [GO:0000422]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; peroxisome fission [GO:0016559]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314]; protein homooligomerization [GO:0051260]; protein targeting to mitochondrion [GO:0006626]; release of cytochrome c from mitochondria [GO:0001836] GO:0000266; GO:0000422; GO:0001836; GO:0005777; GO:0005779; GO:0005783; GO:0005829; GO:0006626; GO:0007204; GO:0008053; GO:0016559; GO:0031307; GO:0032471; GO:0035584; GO:0043234; GO:0043280; GO:0043653; GO:0051260; GO:0051561; GO:0070584; GO:0090141; GO:0090314; GO:2001244 0 0 0 PF14853;PF14852; P91254 CHOYP_GST1.2.2 m.50318 sp GST8_CAEEL 32.727 165 107 2 15 176 39 202 3.44E-23 94.4 GST8_CAEEL reviewed Probable glutathione S-transferase 8 (EC 2.5.1.18) (GST class-sigma) gst-8 F11G11.1 Caenorhabditis elegans 206 0 GO:0004364 0 0 0 PF14497;PF02798; Q01765 CHOYP_SRC.1.2 m.2509 sp EF1A_PODCU 72.794 136 37 0 4 139 326 461 3.44E-65 207 EF1A_PODCU reviewed Elongation factor 1-alpha (EF-1-alpha) TEF Podospora curvicolla 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q02508 CHOYP_contig_013707 m.15651 sp HGV2_HALRO 45.588 68 36 1 19 86 83 149 3.44E-06 47.8 HGV2_HALRO reviewed Protein HGV2 HGV2 Halocynthia roretzi (Sea squirt) (Cynthia roretzi) 510 multicellular organism development [GO:0007275] GO:0005634; GO:0007275 0 0 0 PF10516;PF00515; Q17QJ5 CHOYP_TSPAN18A.1.2 m.15649 sp TSN5_BOVIN 28.829 111 78 1 108 218 14 123 3.44E-11 65.9 TSN5_BOVIN reviewed Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) 268 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007166; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q1RMS8 CHOYP_LOC100377685.1.1 m.58464 sp FBX25_BOVIN 26.07 257 182 3 86 337 102 355 3.44E-23 101 FBX25_BOVIN reviewed F-box only protein 25 FBXO25 Bos taurus (Bovine) 357 protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004842; GO:0005634; GO:0006511; GO:0016567; GO:0019005 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q1ZXD6 CHOYP_LOC100313668.3.6 m.37471 sp ROCO5_DICDI 35.294 85 37 3 57 141 1342 1408 3.44E-07 52.4 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q2L969 CHOYP_LOC663155.1.1 m.62768 sp MTX2_PIG 47.843 255 133 0 3 257 2 256 3.44E-87 263 MTX2_PIG reviewed Metaxin-2 (Mitochondrial outer membrane import complex protein 2) MTX2 Sus scrofa (Pig) 267 protein targeting to mitochondrion [GO:0006626] GO:0005741; GO:0006626 0 0 0 PF17171;PF10568; Q2T9V8 CHOYP_LOC100556247.3.3 m.44511 sp DTD1_BOVIN 67.568 148 48 0 18 165 1 148 3.44E-72 220 DTD1_BOVIN reviewed D-tyrosyl-tRNA(Tyr) deacylase 1 (EC 3.1.-.-) (DNA-unwinding element-binding protein B) (DUE-B) DTD1 HARS2 Bos taurus (Bovine) 209 D-amino acid catabolic process [GO:0019478]; DNA replication [GO:0006260]; tRNA metabolic process [GO:0006399] GO:0002161; GO:0003677; GO:0005634; GO:0005737; GO:0006260; GO:0006399; GO:0019478; GO:0046872; GO:0051500 0 0 cd00563; PF02580; Q4GXU6 CHOYP_RS4.10.11 m.60435 sp RS4_CARGR 75.2 125 30 1 7 131 3 126 3.44E-60 189 RS4_CARGR reviewed 40S ribosomal protein S4 RpS4 Carabus granulatus (Ground beetle) 261 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q4UMH6 CHOYP_AASI_1435.35.35 m.65339 sp Y381_RICFE 23.619 525 312 20 1293 1793 656 1115 3.44E-11 72.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q502J7 CHOYP_DCTN6.1.1 m.18391 sp DCTN6_DANRE 59.574 188 70 2 15 196 7 194 3.44E-74 224 DCTN6_DANRE reviewed Dynactin subunit 6 dctn6 zgc:112102 Danio rerio (Zebrafish) (Brachydanio rerio) 195 0 GO:0000777; GO:0005737; GO:0005869 0 0 0 PF00132; Q502M6 CHOYP_TVAG_067900.6.7 m.33944 sp ANR29_DANRE 33.725 255 149 4 727 981 39 273 3.44E-30 125 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q502M6 CHOYP_TVAG_168010.3.45 m.3898 sp ANR29_DANRE 33.898 177 117 0 3 179 53 229 3.44E-29 112 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5FW48 CHOYP_LOC100369721.1.1 m.17704 sp ASPD_XENTR 56.475 278 109 4 2 267 7 284 3.44E-103 304 ASPD_XENTR reviewed Putative L-aspartate dehydrogenase (EC 1.4.1.21) (Aspartate dehydrogenase domain-containing protein) aspdh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 284 NAD biosynthetic process [GO:0009435]; NADP catabolic process [GO:0006742] GO:0006742; GO:0009435; GO:0033735; GO:0050661 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. 0 0 PF01958;PF03447; Q5HYL7 CHOYP_TM196.1.1 m.29552 sp TM196_HUMAN 30.719 153 93 3 17 165 19 162 3.44E-12 64.7 TM196_HUMAN reviewed Transmembrane protein 196 TMEM196 Homo sapiens (Human) 178 0 GO:0016021 0 0 0 0 Q5R8E2 CHOYP_LOC100369926.4.6 m.49821 sp KLC3_PONAB 27.815 151 104 5 462 610 262 409 3.44E-07 57.4 KLC3_PONAB reviewed Kinesin light chain 3 KLC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 504 0 GO:0003777; GO:0005737; GO:0005871; GO:0005874 0 0 0 0 Q5ZMG5 CHOYP_BRAFLDRAFT_117401.3.3 m.42517 sp AROS_CHICK 29.655 145 90 5 1 140 1 138 3.44E-08 52.4 AROS_CHICK reviewed Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP) RPS19BP1 AROS RCJMB04_2b23 Gallus gallus (Chicken) 140 0 GO:0005654; GO:0005730 0 0 0 PF15684; Q60HC3 CHOYP_NEMVEDRAFT_V1G115454.2.2 m.57908 sp HNRPF_MACFA 56.154 130 55 2 3 131 9 137 3.44E-42 147 HNRPF_MACFA reviewed "Heterogeneous nuclear ribonucleoprotein F (hnRNP F) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]" HNRNPF HNRPF QflA-17741 QtsA-10715 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 415 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003727; GO:0005654; GO:0005681; GO:0006397; GO:0008380; GO:0043484 0 0 0 PF00076;PF08080; Q6H236 CHOYP_DMBT1.34.34 m.64994 sp PEG3_BOVIN 30.023 443 305 4 184 625 1160 1598 3.44E-29 130 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q8R0J4 CHOYP_DPSE_GA11347.1.1 m.28787 sp TM134_MOUSE 31.25 192 122 5 22 205 5 194 3.44E-14 71.2 TM134_MOUSE reviewed Transmembrane protein 134 Tmem134 Mus musculus (Mouse) 195 0 GO:0016021 0 0 0 PF05915; Q96II8 CHOYP_LRCH2.2.2 m.56149 sp LRCH3_HUMAN 54.661 236 106 1 12 247 44 278 3.44E-73 259 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q96MM6 CHOYP_HS12B.1.14 m.13506 sp HS12B_HUMAN 31.343 603 348 15 831 1374 39 634 3.44E-75 268 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96P65 CHOYP_QRFPR.1.1 m.1287 sp QRFPR_HUMAN 20.783 332 213 10 35 328 48 367 3.44E-08 58.2 QRFPR_HUMAN reviewed Pyroglutamylated RFamide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) QRFPR GPR103 Homo sapiens (Human) 431 cellular response to hormone stimulus [GO:0032870]; G-protein coupled receptor signaling pathway [GO:0007186]; response to peptide [GO:1901652] GO:0004930; GO:0004983; GO:0005886; GO:0005887; GO:0007186; GO:0016021; GO:0032870; GO:0042277; GO:1901652 0 0 0 PF00001; Q96RW7 CHOYP_TITIN.11.19 m.38093 sp HMCN1_HUMAN 25.649 308 200 14 333 631 3743 4030 3.44E-10 68.2 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99P31 CHOYP_BRAFLDRAFT_125073.1.1 m.1752 sp HPBP1_MOUSE 39.032 310 172 4 16 311 38 344 3.44E-56 189 HPBP1_MOUSE reviewed Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-interacting protein 1) Hspbp1 Hspbp Mus musculus (Mouse) 357 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398] GO:0004857; GO:0031398; GO:0032436 0 0 0 PF08609; Q9CZJ2 CHOYP_GSPATT00017936001.1.1 m.37458 sp HS12B_MOUSE 29.237 236 152 6 22 245 453 685 3.44E-30 122 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_69390.1.2 m.32820 sp TRIM2_MOUSE 27.053 207 117 8 43 237 523 707 3.44E-07 53.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9XZV3 CHOYP_ISCW_ISCW017554.1.1 m.63285 sp GNAO_GEOCY 54.875 359 162 0 1 359 1 359 3.44E-141 407 GNAO_GEOCY reviewed Guanine nucleotide-binding protein G(o) subunit alpha 0 Geodia cydonium (Sponge) 359 G-protein coupled receptor signaling pathway [GO:0007186] GO:0003924; GO:0004871; GO:0005525; GO:0007186; GO:0046872 0 0 0 PF00503; Q9Z2W1 CHOYP_LOC100121999.2.4 m.44520 sp STK25_MOUSE 78.618 304 63 2 9 310 13 316 3.44E-161 471 STK25_MOUSE reviewed Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) Stk25 Sok1 Mus musculus (Mouse) 426 establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542] GO:0000139; GO:0004702; GO:0005524; GO:0005737; GO:0006468; GO:0007163; GO:0032874; GO:0036481; GO:0042542; GO:0042803; GO:0046777; GO:0046872; GO:0050772; GO:0051645; GO:0051683; GO:0070062; GO:0090168 0 0 0 PF00069; A1L4H1 CHOYP_LOC757271.1.2 m.34471 sp SRCRL_HUMAN 39.355 155 89 1 78 227 413 567 3.45E-28 117 SRCRL_HUMAN reviewed Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D) SSC5D Homo sapiens (Human) 1573 defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; negative regulation of interleukin-8 secretion [GO:2000483] GO:0001968; GO:0005044; GO:0005615; GO:0005622; GO:0005737; GO:0007275; GO:0016020; GO:0031012; GO:0042494; GO:0043236; GO:0045087; GO:0050829; GO:0050830; GO:0050840; GO:2000483 0 0 0 PF00530; A6NJ78 CHOYP_METTL15.1.1 m.14094 sp MET15_HUMAN 49.275 345 165 6 135 473 66 406 3.45E-105 322 MET15_HUMAN reviewed Probable methyltransferase-like protein 15 (EC 2.1.1.-) (Methyltransferase 5 domain-containing protein 1) METTL15 METT5D1 Homo sapiens (Human) 407 rRNA base methylation [GO:0070475] GO:0070475; GO:0071424 0 0 0 PF01795; E9NA96 CHOYP_AAEL_AAEL009813.1.1 m.55332 sp IR25A_DROME 59.317 322 121 4 1 316 570 887 3.45E-132 404 IR25A_DROME reviewed Ionotropic receptor 25a Ir25a CG15627 Drosophila melanogaster (Fruit fly) 947 detection of chemical stimulus involved in sensory perception [GO:0050907]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; rhythmic process [GO:0048511]; transmission of nerve impulse [GO:0019226] GO:0004970; GO:0005234; GO:0005886; GO:0005929; GO:0015026; GO:0015276; GO:0016021; GO:0019226; GO:0030424; GO:0043204; GO:0048511; GO:0050907; GO:0050911; GO:0071683 0 0 0 PF00060;PF10613; O70528 CHOYP_LOC100856794.1.2 m.21381 sp 5HT4R_CAVPO 43.131 313 159 7 31 325 19 330 3.45E-79 251 5HT4R_CAVPO reviewed 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Cavia porcellus (Guinea pig) 388 chemical synaptic transmission [GO:0007268]; regulation of appetite [GO:0032098] GO:0004993; GO:0005768; GO:0005887; GO:0007268; GO:0032098 0 0 0 PF00001; O94854 CHOYP_DDR48.1.1 m.23346 sp K0754_HUMAN 34.211 152 100 0 91 242 862 1013 3.45E-07 55.1 K0754_HUMAN reviewed Uncharacterized protein KIAA0754 KIAA0754 Homo sapiens (Human) 1291 0 GO:0005886 0 0 0 0 O95238 CHOYP_ETS4.1.2 m.25824 sp SPDEF_HUMAN 42.231 251 106 4 172 421 122 334 3.45E-57 194 SPDEF_HUMAN reviewed SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) SPDEF PDEF PSE Homo sapiens (Human) 335 "cell differentiation [GO:0030154]; intestinal epithelial cell development [GO:0060576]; lung goblet cell differentiation [GO:0060480]; multicellular organism development [GO:0007275]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000981; GO:0005634; GO:0006351; GO:0007275; GO:0010454; GO:0010455; GO:0030154; GO:0043065; GO:0043565; GO:0045944; GO:0060480; GO:0060576 0 0 0 PF00178;PF02198; P78329 CHOYP_BRAFLDRAFT_61250.11.14 m.49882 sp CP4F2_HUMAN 41.489 470 244 13 45 496 61 517 3.45E-118 360 CP4F2_HUMAN reviewed Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.13.194) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.13.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.13.30) CYP4F2 Homo sapiens (Human) 520 arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; oxidation-reduction process [GO:0055114]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377] GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006690; GO:0006691; GO:0007596; GO:0008217; GO:0008392; GO:0016324; GO:0016709; GO:0017144; GO:0018685; GO:0019369; GO:0019373; GO:0020037; GO:0031090; GO:0032304; GO:0032305; GO:0036101; GO:0042360; GO:0042361; GO:0042376; GO:0042377; GO:0043231; GO:0050051; GO:0052869; GO:0052871; GO:0052872; GO:0055078; GO:0055114; GO:0097258; GO:0097259; GO:0097267 PATHWAY: Cofactor degradation; phylloquinone degradation. {ECO:0000269|PubMed:24138531}. 0 0 PF00067; P79781 CHOYP_ABCF2.1.2 m.28364 sp RS27A_CHICK 94.318 88 5 0 1 88 1 88 3.45E-50 158 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; P79781 CHOYP_NEMVEDRAFT_V1G159364.1.1 m.22912 sp RS27A_CHICK 89.796 147 14 1 13 158 8 154 3.45E-81 239 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; Q02357 CHOYP_TVAG_168010.6.45 m.21056 sp ANK1_MOUSE 38.498 213 131 0 2 214 200 412 3.45E-38 144 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q10002 CHOYP_LOC592745.1.1 m.47718 sp APN1_CAEEL 51.254 279 133 1 715 993 118 393 3.45E-100 323 APN1_CAEEL reviewed DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease) (AP endonuclease) apn-1 T05H10.2 Caenorhabditis elegans 396 base-excision repair [GO:0006284] GO:0003677; GO:0003906; GO:0005634; GO:0005739; GO:0006284; GO:0008081; GO:0008270; GO:0008311; GO:0017005 0 0 0 PF01261; Q12118 CHOYP_MGL_2397.1.1 m.22915 sp SGT2_YEAST 34.737 95 55 1 10 104 90 177 3.45E-10 58.9 SGT2_YEAST reviewed Small glutamine-rich tetratricopeptide repeat-containing protein 2 (SGT/UBP) (Viral protein U-binding protein) SGT2 YOR007C UNF346 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 346 posttranslational protein targeting to membrane [GO:0006620]; response to heat [GO:0009408] GO:0006620; GO:0009408; GO:0032947; GO:0072380 0 0 0 PF16546;PF00515; Q12834 CHOYP_CDC20.1.1 m.49883 sp CDC20_HUMAN 31.121 437 281 9 7 434 69 494 3.45E-69 230 CDC20_HUMAN reviewed Cell division cycle protein 20 homolog (p55CDC) CDC20 Homo sapiens (Human) 499 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell cycle [GO:0007049]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of cell proliferation [GO:0008284]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of dendrite development [GO:0050773]; regulation of meiotic nuclear division [GO:0040020]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; sister chromatid cohesion [GO:0007062] GO:0000922; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0007049; GO:0007062; GO:0007067; GO:0008022; GO:0008284; GO:0019899; GO:0031145; GO:0031915; GO:0040020; GO:0042787; GO:0043161; GO:0043234; GO:0048471; GO:0050773; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0090129; GO:0097027; GO:1904668 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12894;PF00400; Q21313 CHOYP_LOC100375762.1.1 m.3921 sp EPI1_CAEEL 35.632 174 99 7 12 182 3002 3165 3.45E-14 74.3 EPI1_CAEEL reviewed Laminin-like protein epi-1 epi-1 K08C7.3 Caenorhabditis elegans 3672 axonal defasciculation [GO:0007414]; basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; neuron migration [GO:0001764]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of locomotion [GO:0040017]; regulation of cell proliferation [GO:0042127]; reproduction [GO:0000003]; response to heat [GO:0009408]; response to misfolded protein [GO:0051788] GO:0000003; GO:0001764; GO:0005604; GO:0007155; GO:0007414; GO:0009408; GO:0010950; GO:0016477; GO:0040017; GO:0042127; GO:0051788; GO:0071711 0 0 0 PF00052;PF00053;PF00054;PF02210;PF06009;PF00055; Q4UMH6 CHOYP_ANK2.2.8 m.33404 sp Y381_RICFE 24.304 395 238 14 18 385 669 1029 3.45E-17 87.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q4ZJM9 CHOYP_C1QL3.1.5 m.23596 sp C1QL4_MOUSE 32.061 131 82 4 40 167 109 235 3.45E-10 60.1 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q55E58 CHOYP_NEMVEDRAFT_V1G199564.6.6 m.64358 sp PATS1_DICDI 25.455 275 159 9 438 711 1793 2022 3.45E-15 85.1 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5ZJD7 CHOYP_EXO1.1.2 m.16959 sp YIPF4_CHICK 51.852 108 48 2 37 144 15 118 3.45E-27 108 YIPF4_CHICK reviewed Protein YIPF4 (YIP1 family member 4) YIPF4 RCJMB04_19b22 Gallus gallus (Chicken) 249 0 GO:0005783; GO:0005794; GO:0005886; GO:0016021 0 0 0 PF04893; Q6PV61 CHOYP_CPIPJ_CPIJ012408.1.1 m.10724 sp H2A_LITVA 96.721 122 4 0 24 145 1 122 3.45E-81 238 H2A_LITVA reviewed Histone H2A 0 Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei) 123 defense response to bacterium [GO:0042742] GO:0000786; GO:0003677; GO:0005634; GO:0042742 0 0 0 PF00125;PF16211; Q6Q899 CHOYP_IFIH1.6.14 m.43199 sp DDX58_MOUSE 28.541 946 583 32 135 1025 14 921 3.45E-94 323 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q8LAC4 CHOYP_LOC100375206.1.1 m.8724 sp URH2_ARATH 39.462 223 132 2 3 225 7 226 3.45E-44 156 URH2_ARATH reviewed Probable uridine nucleosidase 2 (EC 3.2.2.3) (Uridine ribohydrolase 2) URH2 At1g05620 F3F20.7 Arabidopsis thaliana (Mouse-ear cress) 322 inosine catabolic process [GO:0006148]; leaf senescence [GO:0010150] GO:0005829; GO:0006148; GO:0010150; GO:0035251; GO:0045437; GO:0047724 0 0 0 PF01156; Q969N2 CHOYP_LOC100374276.1.1 m.15243 sp PIGT_HUMAN 46.858 557 279 12 32 578 27 576 3.45E-168 494 PIGT_HUMAN reviewed GPI transamidase component PIG-T (Phosphatidylinositol-glycan biosynthesis class T protein) PIGT CGI-06 PSEC0163 UNQ716/PRO1379 Homo sapiens (Human) 578 attachment of GPI anchor to protein [GO:0016255]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182] GO:0003923; GO:0005789; GO:0016020; GO:0016023; GO:0016255; GO:0030176; GO:0030182; GO:0042765; GO:0051402 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF04113; Q9D5U8 CHOYP_LOC100366458.2.2 m.65535 sp CNBD2_MOUSE 24.353 464 298 12 265 711 149 576 3.45E-27 121 CNBD2_MOUSE reviewed Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function) Cnbd2 Cris Mus musculus (Mouse) 673 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q9ESN6 CHOYP_TRIM3.2.58 m.2844 sp TRIM2_MOUSE 31.068 206 127 7 202 400 536 733 3.45E-14 77.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H161 CHOYP_ISX.1.1 m.14007 sp ALX4_HUMAN 39.175 97 54 1 353 444 176 272 3.45E-15 81.3 ALX4_HUMAN reviewed Homeobox protein aristaless-like 4 ALX4 KIAA1788 Homo sapiens (Human) 411 anterior/posterior pattern specification [GO:0009952]; digestive tract development [GO:0048565]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic skeletal system morphogenesis [GO:0048704]; hair follicle development [GO:0001942]; muscle organ development [GO:0007517]; palate development [GO:0060021]; post-embryonic development [GO:0009791]; regulation of apoptotic process [GO:0042981]; skeletal system development [GO:0001501] GO:0000977; GO:0001228; GO:0001501; GO:0001942; GO:0003677; GO:0005634; GO:0005667; GO:0007517; GO:0009791; GO:0009952; GO:0035115; GO:0035116; GO:0042733; GO:0042981; GO:0048565; GO:0048704; GO:0060021 0 0 0 PF00046;PF03826; Q9P2E3 CHOYP_BRAFLDRAFT_234854.2.2 m.58013 sp ZNFX1_HUMAN 32.687 361 220 6 2 358 707 1048 3.45E-44 166 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9QZS7 CHOYP_LOC592278.1.1 m.51063 sp NPHN_MOUSE 22.685 745 467 32 73 734 318 1036 3.45E-20 100 NPHN_MOUSE reviewed Nephrin (Renal glomerulus-specific cell adhesion receptor) Nphs1 Nphn Mus musculus (Mouse) 1256 cell adhesion [GO:0007155]; glomerular basement membrane development [GO:0032836]; glomerular visceral epithelial cell development [GO:0072015]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; myoblast fusion [GO:0007520]; positive regulation of actin filament polymerization [GO:0030838]; protein localization to synapse [GO:0035418]; regulation of excretion [GO:0044062]; skeletal muscle tissue development [GO:0007519] GO:0000165; GO:0005622; GO:0005886; GO:0005887; GO:0007155; GO:0007254; GO:0007519; GO:0007520; GO:0016021; GO:0017022; GO:0030838; GO:0032836; GO:0035418; GO:0036057; GO:0042995; GO:0044062; GO:0070062; GO:0072015 0 0 0 PF08205;PF00041; Q9ULJ7 CHOYP_TVAG_332510.1.2 m.30682 sp ANR50_HUMAN 31.21 157 104 3 40 196 947 1099 3.45E-18 87.4 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9UM22 CHOYP_BRAFLDRAFT_269209.1.1 m.4681 sp EPDR1_HUMAN 26.772 127 88 3 11 135 30 153 3.45E-12 65.9 EPDR1_HUMAN reviewed Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; Q9Y2G4 CHOYP_ANKRD6.1.2 m.12916 sp ANKR6_HUMAN 47.529 263 133 1 31 293 11 268 3.45E-73 263 ANKR6_HUMAN reviewed Ankyrin repeat domain-containing protein 6 (Diversin) ANKRD6 KIAA0957 Homo sapiens (Human) 727 "negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]" GO:0005634; GO:0005737; GO:0043231; GO:0046330; GO:0090090; GO:2000096 0 0 0 PF12796; Q9Y6R1 CHOYP_S4A4.1.1 m.15028 sp S4A4_HUMAN 44.079 304 153 4 1 291 481 780 3.45E-72 243 S4A4_HUMAN reviewed Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1) SLC4A4 NBC NBC1 NBCE1 Homo sapiens (Human) 1079 bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814]; transport [GO:0006810] GO:0005452; GO:0005886; GO:0005887; GO:0006810; GO:0006814; GO:0008510; GO:0015701; GO:0016323; GO:0051453; GO:0070062 0 0 0 PF07565;PF00955; A2ALS5 CHOYP_LOC100889245.1.2 m.999 sp RPGP1_MOUSE 52.37 422 180 9 310 722 1 410 3.46E-129 407 RPGP1_MOUSE reviewed Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) (ARPP-90) Rap1gap Kiaa0474 Rap1ga1 Mus musculus (Mouse) 663 negative regulation of microvillus assembly [GO:1903697]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of GTPase activity [GO:0043547]; positive regulation of phagocytosis [GO:0050766]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0000139; GO:0005096; GO:0005829; GO:0016020; GO:0017016; GO:0022409; GO:0042803; GO:0043087; GO:0043547; GO:0050766; GO:0051056; GO:1903697 0 0 0 PF02188;PF02145; A4FV48 CHOYP_LOC100373185.1.1 m.11782 sp FADS2_BOVIN 53.095 420 192 2 47 461 24 443 3.46E-168 483 FADS2_BOVIN reviewed Fatty acid desaturase 2 (EC 1.14.19.-) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) FADS2 Bos taurus (Bovine) 444 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005789; GO:0006636; GO:0016021 PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. 0 0 PF00173;PF00487; A9UL59 CHOYP_LOC100004180.1.1 m.11063 sp TM211_XENTR 29.703 202 128 4 1 200 2 191 3.46E-16 76.3 TM211_XENTR reviewed Transmembrane protein 211 tmem211 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 191 0 GO:0016021 0 0 0 PF10242; E1BD59 CHOYP_TRI56.2.4 m.5497 sp TRI56_BOVIN 41.04 173 88 5 39 203 9 175 3.46E-32 125 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; F1M3L7 CHOYP_EPS8.2.2 m.49218 sp EPS8_RAT 33.766 385 185 11 296 675 266 585 3.46E-53 204 EPS8_RAT reviewed Epidermal growth factor receptor kinase substrate 8 Eps8 Rattus norvegicus (Rat) 822 actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360] GO:0003779; GO:0005903; GO:0005938; GO:0008344; GO:0008360; GO:0010458; GO:0014069; GO:0016601; GO:0017146; GO:0030054; GO:0030426; GO:0030832; GO:0031532; GO:0032420; GO:0032587; GO:0035591; GO:0036336; GO:0048149; GO:0048365; GO:0051016; GO:0051017; GO:0051764; GO:0070062; GO:0070358 0 0 0 PF08416;PF00018; O88281 CHOYP_LOC557764.1.1 m.54756 sp MEGF6_RAT 45.349 86 46 1 50 135 1283 1367 3.46E-12 67.4 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O95620 CHOYP_BRAFLDRAFT_129997.1.1 m.10426 sp DUS4L_HUMAN 64.074 270 97 0 1 270 48 317 3.46E-134 384 DUS4L_HUMAN reviewed tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.-) (pp35) (tRNA-dihydrouridine synthase 4-like) DUS4L Homo sapiens (Human) 317 0 GO:0005829; GO:0017150; GO:0050660 0 0 0 PF01207; P0C6B8 CHOYP_BRAFLDRAFT_129759.1.2 m.13757 sp SVEP1_RAT 45.679 162 83 4 317 476 1192 1350 3.46E-34 141 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P17978 CHOYP_LOC100369014.8.9 m.53287 sp VGB_STAAU 26.02 196 132 7 240 431 89 275 3.46E-06 52 VGB_STAAU reviewed Virginiamycin B lyase (EC 4.2.99.-) (Streptogramin B lyase) vgb vgh Staphylococcus aureus 299 antibiotic catabolic process [GO:0017001]; response to antibiotic [GO:0046677] GO:0000287; GO:0016835; GO:0017001; GO:0046677 0 0 0 0 P18700 CHOYP_BRAFLDRAFT_60807.2.2 m.50658 sp TBB_STRPU 97.196 214 6 0 1 214 78 291 3.46E-157 439 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P18700 CHOYP_LOC373275.3.7 m.38057 sp TBB_STRPU 97.196 214 6 0 1 214 78 291 3.46E-157 439 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P31674 CHOYP_ISCW_ISCW016148.2.6 m.39617 sp RS15_ORYSJ 72.8 125 31 2 13 134 1 125 3.46E-59 182 RS15_ORYSJ reviewed 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) 154 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00203; P83425 CHOYP_BRAFLDRAFT_69134.11.13 m.59757 sp HIP_MYTED 32.743 113 75 1 49 161 85 196 3.46E-12 65.5 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q0QWG9 CHOYP_LOC561017.1.1 m.46499 sp GRD2I_MOUSE 27.902 448 247 9 100 478 13 453 3.46E-39 161 GRD2I_MOUSE reviewed "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" Grid2ip Mus musculus (Mouse) 1203 actin cytoskeleton organization [GO:0030036]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; long term synaptic depression [GO:0060292] GO:0007216; GO:0030036; GO:0030054; GO:0043197; GO:0045202; GO:0045211; GO:0060292 0 0 0 PF02181;PF00595; Q13263 CHOYP_LOC100369754.10.10 m.65252 sp TIF1B_HUMAN 28.144 167 111 6 1 162 134 296 3.46E-07 52.8 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q4GZT3 CHOYP_REJ5.1.2 m.29903 sp PKD2_BOVIN 27.637 474 294 10 4 465 272 708 3.46E-51 192 PKD2_BOVIN reviewed Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Transient receptor potential cation channel subfamily P member 2) PKD2 TRPP2 Bos taurus (Bovine) 970 "aorta development [GO:0035904]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell cycle arrest [GO:0007050]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to osmotic stress [GO:0071470]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; determination of liver left/right asymmetry [GO:0071910]; embryonic placenta development [GO:0001892]; heart looping [GO:0001947]; JAK-STAT cascade [GO:0007259]; mesonephric duct development [GO:0072177]; metanephric ascending thin limb development [GO:0072218]; metanephric cortex development [GO:0072214]; metanephric cortical collecting duct development [GO:0072219]; metanephric distal tubule development [GO:0072235]; metanephric mesenchyme development [GO:0072075]; metanephric part of ureteric bud development [GO:0035502]; metanephric smooth muscle tissue development [GO:0072208]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neural tube development [GO:0021915]; placenta blood vessel development [GO:0060674]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cAMP metabolic process [GO:0030814]; regulation of cell proliferation [GO:0042127]; renal artery morphogenesis [GO:0061441]; spinal cord development [GO:0021510]" GO:0001658; GO:0001892; GO:0001947; GO:0002133; GO:0003127; GO:0005245; GO:0005248; GO:0005262; GO:0005267; GO:0005509; GO:0005887; GO:0005911; GO:0007050; GO:0007259; GO:0009925; GO:0016020; GO:0021510; GO:0021915; GO:0030027; GO:0030814; GO:0031512; GO:0031513; GO:0031587; GO:0031659; GO:0031941; GO:0035502; GO:0035904; GO:0036064; GO:0042127; GO:0042994; GO:0045180; GO:0045429; GO:0045944; GO:0048763; GO:0050982; GO:0060170; GO:0060315; GO:0060674; GO:0061441; GO:0070062; GO:0071158; GO:0071458; GO:0071464; GO:0071470; GO:0071498; GO:0071556; GO:0071910; GO:0072075; GO:0072177; GO:0072208; GO:0072214; GO:0072218; GO:0072219; GO:0072235; GO:0072284; GO:0072686; GO:2000134 0 0 0 PF08016; Q4ZJM9 CHOYP_LOC100561667.1.4 m.22652 sp C1QL4_MOUSE 32.353 136 77 6 51 182 109 233 3.46E-09 57.8 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q502K2 CHOYP_SAMH1.7.12 m.36289 sp SAMH1_DANRE 55.675 467 193 6 70 525 93 556 3.46E-175 511 SAMH1_DANRE reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) 622 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966;PF07647; Q5DTL9 CHOYP_S4A10.4.4 m.38363 sp S4A10_MOUSE 52.19 274 104 5 1 274 871 1117 3.46E-82 272 S4A10_MOUSE reviewed Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10) Slc4a10 Kiaa4136 Ncbe Mus musculus (Mouse) 1118 bicarbonate transport [GO:0015701]; brain morphogenesis [GO:0048854]; hydrogen ion transmembrane transport [GO:1902600]; locomotory exploration behavior [GO:0035641]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; protein glycosylation [GO:0006486]; pyramidal neuron development [GO:0021860]; regulation of cellular pH [GO:0030641]; regulation of intracellular pH [GO:0051453]; regulation of pH [GO:0006885]; response to light stimulus [GO:0009416]; sodium ion transport [GO:0006814] GO:0005452; GO:0005886; GO:0005887; GO:0006486; GO:0006814; GO:0006885; GO:0009416; GO:0009791; GO:0015293; GO:0015301; GO:0015701; GO:0016323; GO:0021860; GO:0030641; GO:0035264; GO:0035641; GO:0043025; GO:0048854; GO:0051453; GO:0097440; GO:0097441; GO:0097442; GO:1902600 0 0 0 PF07565;PF00955; Q6P3P4 CHOYP_KCD15.1.1 m.10647 sp KCD15_XENTR 54.922 193 73 2 1 193 59 237 3.46E-72 221 KCD15_XENTR reviewed BTB/POZ domain-containing protein kctd15 (Potassium channel tetramerization domain-containing protein 15) kctd15 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 255 multicellular organism development [GO:0007275]; protein homooligomerization [GO:0051260] GO:0007275; GO:0051260 0 0 0 PF02214; Q6PCJ9 CHOYP_BRAFLDRAFT_276374.1.1 m.58734 sp PPT2A_XENLA 46.52 273 140 5 16 286 28 296 3.46E-87 265 PPT2A_XENLA reviewed Lysosomal thioesterase PPT2-A (PPT-2-A) (EC 3.1.2.-) ppt2-a Xenopus laevis (African clawed frog) 296 0 GO:0005764; GO:0008474 0 0 0 PF02089; Q7TSH8 CHOYP_LOC100123810.2.2 m.52182 sp TMM94_MOUSE 33.206 786 420 18 113 811 118 885 3.46E-116 397 TMM94_MOUSE reviewed Transmembrane protein 94 Tmem94 Kiaa0195 Mus musculus (Mouse) 1360 0 GO:0005654; GO:0016021 0 0 0 0 Q8INB9 CHOYP_BRAFLDRAFT_76536.2.2 m.59146 sp AKT1_DROME 27.523 218 133 7 766 975 275 475 3.46E-10 67.8 AKT1_DROME reviewed RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Akt) (Protein kinase B) (PKB) Akt1 CG4006 Drosophila melanogaster (Fruit fly) 611 "apoptotic process [GO:0006915]; chitin-based embryonic cuticle biosynthetic process [GO:0008362]; circadian rhythm [GO:0007623]; dendrite regeneration [GO:0031104]; epithelial cell migration, open tracheal system [GO:0007427]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; long term synaptic depression [GO:0060292]; multicellular organism growth [GO:0035264]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron death [GO:1901215]; negative regulation of peptide hormone secretion [GO:0090278]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell growth [GO:0030307]; positive regulation of cell size [GO:0045793]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of organ growth [GO:0046622]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of dendrite development [GO:0050773]; regulation of glucose metabolic process [GO:0010906]; regulation of hemocyte proliferation [GO:0035206]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein import into nucleus [GO:0042306]; response to oxidative stress [GO:0006979]; somatic muscle development [GO:0007525]" GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0006629; GO:0006915; GO:0006979; GO:0007424; GO:0007427; GO:0007520; GO:0007525; GO:0007623; GO:0008286; GO:0008360; GO:0008361; GO:0008362; GO:0009986; GO:0010906; GO:0018105; GO:0019915; GO:0030307; GO:0031104; GO:0035091; GO:0035206; GO:0035264; GO:0035556; GO:0040014; GO:0040018; GO:0042306; GO:0043025; GO:0043066; GO:0045793; GO:0045886; GO:0046620; GO:0046622; GO:0048477; GO:0048680; GO:0050773; GO:0060292; GO:0090278; GO:1901215 0 0 0 PF00169;PF00069;PF00433; Q8R431 CHOYP_MGLL.1.1 m.25620 sp MGLL_RAT 43.137 153 87 0 1 153 43 195 3.46E-38 135 MGLL_RAT reviewed Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL) Mgll Mgl2 Rattus norvegicus (Rat) 303 acylglycerol catabolic process [GO:0046464]; arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; lipid metabolic process [GO:0006629]; regulation of inflammatory response [GO:0050727]; regulation of sensory perception of pain [GO:0051930]; regulation of signal transduction [GO:0009966]; triglyceride catabolic process [GO:0019433] GO:0005811; GO:0005829; GO:0006629; GO:0006633; GO:0008289; GO:0009966; GO:0016020; GO:0016787; GO:0019369; GO:0019433; GO:0019898; GO:0045202; GO:0046464; GO:0047372; GO:0050727; GO:0051930 PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. {ECO:0000250|UniProtKB:O35678}. 0 0 PF12146; Q8SWR2 CHOYP_BICRD.1.1 m.11088 sp BICRD_DROME 28.094 598 292 15 18 591 101 584 3.46E-35 144 BICRD_DROME reviewed Bicaudal D-related protein homolog (BICD-related protein homolog) CG17365 CG32137 Drosophila melanogaster (Fruit fly) 620 neuron projection morphogenesis [GO:0048812] GO:0048812 0 0 0 0 Q8VE97 CHOYP_SRSF4.1.6 m.5878 sp SRSF4_MOUSE 71.2 125 26 2 3 125 2 118 3.46E-51 172 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q8WVN8 CHOYP_ISCW_ISCW000642.1.1 m.4065 sp UB2Q2_HUMAN 54.787 376 152 6 4 364 3 375 3.46E-141 408 UB2Q2_HUMAN reviewed Ubiquitin-conjugating enzyme E2 Q2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q2) (Ubiquitin carrier protein Q2) (Ubiquitin-protein ligase Q2) UBE2Q2 Homo sapiens (Human) 375 protein K48-linked ubiquitination [GO:0070936] GO:0004842; GO:0005524; GO:0005737; GO:0061631; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q96LT4 CHOYP_BRAFLDRAFT_288304.1.1 m.25218 sp SAMD8_HUMAN 53.367 401 156 4 14 386 9 406 3.46E-151 437 SAMD8_HUMAN reviewed Sphingomyelin synthase-related protein 1 (SMSr) (EC 2.7.8.-) (Ceramide phosphoethanolamine synthase) (CPE synthase) (Sterile alpha motif domain-containing protein 8) (SAM domain-containing protein 8) SAMD8 Homo sapiens (Human) 415 ceramide biosynthetic process [GO:0046513]; regulation of ceramide biosynthetic process [GO:2000303]; sphingomyelin biosynthetic process [GO:0006686] GO:0006686; GO:0016021; GO:0016740; GO:0030176; GO:0046513; GO:2000303 0 0 0 PF14360;PF00536; Q9DAZ9 CHOYP_LOC591968.1.1 m.37093 sp ANCHR_MOUSE 32.407 432 223 12 3 421 5 380 3.46E-56 193 ANCHR_MOUSE reviewed Abscission/NoCut checkpoint regulator (ANCHR) (Zinc finger FYVE domain-containing protein 19) Zfyve19 Anchr Mus musculus (Mouse) 389 abscission [GO:0009838]; cell cycle [GO:0007049]; cell division [GO:0051301]; negative regulation of cytokinesis [GO:0032466] GO:0005737; GO:0005813; GO:0007049; GO:0009838; GO:0030496; GO:0032154; GO:0032266; GO:0032466; GO:0046872; GO:0051301 0 0 0 PF01363; Q9H8L6 CHOYP_CBLN13.7.9 m.50422 sp MMRN2_HUMAN 32.117 137 86 3 73 205 797 930 3.46E-10 62.8 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; Q9R024 CHOYP_NGR-A5.1.1 m.44675 sp OPSG_CAVPO 24.167 240 157 9 43 269 38 265 3.46E-09 61.6 OPSG_CAVPO reviewed Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (Medium wavelength-sensitive cone opsin) OPN1MW GCP Cavia porcellus (Guinea pig) 364 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0001750; GO:0004930; GO:0005886; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; Q9UBC9 CHOYP_contig_037893 m.42744 sp SPRR3_HUMAN 42.683 82 47 0 32 113 43 124 3.46E-13 66.6 SPRR3_HUMAN reviewed Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin) SPRR3 SPRC Homo sapiens (Human) 169 epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; wound healing [GO:0042060] GO:0001533; GO:0005198; GO:0005737; GO:0008544; GO:0018149; GO:0030216; GO:0031424; GO:0042060; GO:0070062 0 0 0 0 Q9Y5Q5 CHOYP_CORIN.2.2 m.40858 sp CORIN_HUMAN 28.067 595 363 16 1082 1626 455 1034 3.46E-58 224 CORIN_HUMAN reviewed "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) 1042 female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] GO:0003050; GO:0004252; GO:0005576; GO:0005886; GO:0005887; GO:0007565; GO:0008217; GO:0009986; GO:0016021; GO:0016486; GO:0035813; GO:1903779 0 0 cd00190; PF01392;PF00057;PF15494;PF00089; E9QAM5 CHOYP_RRP44.1.1 m.4674 sp HELZ2_MOUSE 25.731 342 218 13 809 1141 1352 1666 3.47E-23 111 HELZ2_MOUSE reviewed Helicase with zinc finger domain 2 (EC 3.6.4.-) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) Helz2 Mus musculus (Mouse) 2947 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 O75382 CHOYP_TRIM3.26.58 m.32809 sp TRIM3_HUMAN 25.524 286 184 14 44 310 469 744 3.47E-07 55.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06868 CHOYP_LOC100702400.1.1 m.19218 sp PLMN_BOVIN 49.405 168 62 5 268 416 196 359 3.47E-42 161 PLMN_BOVIN reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; response to heat [GO:0009408]; tissue remodeling [GO:0048771] GO:0004252; GO:0005102; GO:0005576; GO:0007596; GO:0009408; GO:0019904; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; Q02650 CHOYP_MTHSD.1.2 m.36415 sp PAX5_MOUSE 63.91 133 46 1 179 311 13 143 3.47E-51 187 PAX5_MOUSE reviewed Paired box protein Pax-5 (B-cell-specific transcription factor) (BSAP) Pax5 Pax-5 Mus musculus (Mouse) 391 "adult behavior [GO:0030534]; aging [GO:0007568]; cerebral cortex development [GO:0021987]; dopaminergic neuron differentiation [GO:0071542]; embryonic cranial skeleton morphogenesis [GO:0048701]; lateral ventricle development [GO:0021670]; negative regulation of histone H3-K9 methylation [GO:0051573]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; organ morphogenesis [GO:0009887]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; skeletal muscle cell differentiation [GO:0035914]; spermatogenesis [GO:0007283]" GO:0000122; GO:0000978; GO:0001077; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0006355; GO:0007283; GO:0007568; GO:0009887; GO:0021670; GO:0021987; GO:0030534; GO:0035914; GO:0045892; GO:0045893; GO:0045944; GO:0048701; GO:0051573; GO:0071542 0 0 0 PF00292;PF12403; Q04202 CHOYP_LOC100207270.3.3 m.63004 sp TCB2_CAEBR 24.9 249 178 7 108 351 29 273 3.47E-18 86.7 TCB2_CAEBR reviewed Transposable element Tcb2 transposase 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; Q14766 CHOYP_LOC100632702.1.1 m.61382 sp LTBP1_HUMAN 32.438 484 236 27 2 460 896 1313 3.47E-34 144 LTBP1_HUMAN reviewed Latent-transforming growth factor beta-binding protein 1 (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1) LTBP1 Homo sapiens (Human) 1721 aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; ventricular septum development [GO:0003281] GO:0001527; GO:0003281; GO:0005024; GO:0005509; GO:0005576; GO:0005578; GO:0031012; GO:0035583; GO:0035904; GO:0043234; GO:0050431; GO:0050436; GO:0060976 0 0 0 PF12662;PF07645;PF00683; Q5SZT7 CHOYP_U396.1.1 m.52286 sp NKAPL_MOUSE 64.234 137 45 2 299 433 258 392 3.47E-49 175 NKAPL_MOUSE reviewed NKAP-like protein Nkapl Mus musculus (Mouse) 395 0 0 0 0 0 PF06047; Q61EX6 CHOYP_LOC752805.3.3 m.43456 sp NAS36_CAEBR 31.871 342 203 14 108 431 102 431 3.47E-34 143 NAS36_CAEBR reviewed Zinc metalloproteinase nas-36 (EC 3.4.24.21) (Nematode astacin 36) nas-36 CBG11886 Caenorhabditis briggsae 616 "molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; multicellular organism development [GO:0007275]" GO:0004222; GO:0005576; GO:0007275; GO:0008270; GO:0018996 0 0 0 PF01400;PF00431;PF00090; Q7Z591 CHOYP_LOC756958.2.2 m.21146 sp AKNA_HUMAN 28.846 260 155 7 565 815 427 665 3.47E-21 105 AKNA_HUMAN reviewed AT-hook-containing transcription factor AKNA KIAA1968 Homo sapiens (Human) 1439 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0005634; GO:0016020; GO:0045944 0 0 0 PF12443; Q8C6L5 CHOYP_CGAS.3.6 m.34645 sp CGAS_MOUSE 30.952 84 56 1 3 84 397 480 3.47E-06 51.2 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8TB96 CHOYP_ITFG1.1.1 m.51655 sp TIP_HUMAN 39.635 603 331 15 44 634 31 612 3.47E-142 429 TIP_HUMAN reviewed T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin) ITFG1 LNKN-1 TIP CDA08 Homo sapiens (Human) 612 0 GO:0016021; GO:0070062 0 0 0 0 Q92193 CHOYP_ACTC.3.6 m.21572 sp ACT_CRAVI 94.231 156 9 0 1 156 36 191 3.47E-105 305 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q99489 CHOYP_LOC100697237.1.1 m.40240 sp OXDD_HUMAN 43.182 308 164 6 3 304 25 327 3.47E-82 255 OXDD_HUMAN reviewed D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Homo sapiens (Human) 341 aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; glyoxylate metabolic process [GO:0046487]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insemination [GO:0007320] GO:0005102; GO:0005777; GO:0005782; GO:0006531; GO:0006533; GO:0007320; GO:0007625; GO:0008445; GO:0019478; GO:0042445; GO:0046487; GO:0048037; GO:0071949 0 0 0 PF01266; Q9CR24 CHOYP_NUDT8.1.1 m.8711 sp NUDT8_MOUSE 46.328 177 88 3 78 253 32 202 3.47E-48 161 NUDT8_MOUSE reviewed Nucleoside diphosphate-linked moiety X motif 8 (Nudix motif 8) (EC 3.6.1.-) Nudt8 Mus musculus (Mouse) 210 0 GO:0005739; GO:0016787; GO:0046872 0 0 0 PF00293; Q9ESN6 CHOYP_LOC100213744.13.19 m.44652 sp TRIM2_MOUSE 22.963 270 181 10 299 552 486 744 3.47E-08 60.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9QUN3 CHOYP_BLNK.1.1 m.26071 sp BLNK_MOUSE 34.513 113 70 3 147 256 342 453 3.47E-15 78.2 BLNK_MOUSE reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) Blnk Bash Ly57 Slp65 Mus musculus (Mouse) 457 B cell activation [GO:0042113]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005737; GO:0005886; GO:0006955; GO:0035556; GO:0042113 0 0 0 PF00017; Q9UBB5 CHOYP_ISCW_ISCW010143.1.3 m.17397 sp MBD2_HUMAN 51.626 246 108 5 4 244 148 387 3.47E-80 249 MBD2_HUMAN reviewed Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) MBD2 Homo sapiens (Human) 411 "ATP-dependent chromatin remodeling [GO:0043044]; cellular protein complex assembly [GO:0043623]; chromatin silencing at rDNA [GO:0000183]; maternal behavior [GO:0042711]; methylation-dependent chromatin silencing [GO:0006346]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of cell proliferation [GO:0042127]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000122; GO:0000183; GO:0000790; GO:0000792; GO:0003682; GO:0003696; GO:0003729; GO:0005634; GO:0005654; GO:0005737; GO:0006346; GO:0006351; GO:0008327; GO:0019904; GO:0030177; GO:0035197; GO:0042127; GO:0042711; GO:0043044; GO:0043234; GO:0043623; GO:0045892; GO:0070742 0 0 0 PF01429;PF14048;PF16564; T1DKS4 CHOYP_SCHCODRAFT_63192.1.1 m.60640 sp TCTP_CROHD 51.095 137 60 3 7 140 39 171 3.47E-41 138 TCTP_CROHD reviewed Translationally-controlled tumor protein homolog (TCTP) 0 Crotalus horridus (Timber rattlesnake) 172 0 GO:0005576 0 0 0 PF00838; A4IF63 CHOYP_BRAFLDRAFT_86897.1.3 m.1885 sp TRIM2_BOVIN 28.571 119 75 2 14 122 625 743 3.48E-07 50.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IGH4 CHOYP_LOC100700230.1.1 m.57851 sp WDR4_DANRE 38.542 288 162 6 18 291 32 318 3.48E-52 179 WDR4_DANRE reviewed tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4 (WD repeat-containing protein 4) wdr4 si:ch211-140m22.6 Danio rerio (Zebrafish) (Brachydanio rerio) 413 RNA (guanine-N7)-methylation [GO:0036265]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400] GO:0005634; GO:0006400; GO:0030488; GO:0036265 PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03056}. 0 0 0 A6QQL5 CHOYP_LOC576665.1.2 m.10867 sp CB073_BOVIN 35.115 131 80 4 115 244 54 180 3.48E-11 66.2 CB073_BOVIN reviewed Uncharacterized protein C2orf73 homolog 0 Bos taurus (Bovine) 290 0 0 0 0 0 PF15667; E1BLZ4 CHOYP_ZFY26.1.2 m.23008 sp ZFY26_BOVIN 40.123 162 73 6 2 158 1776 1918 3.48E-15 75.1 ZFY26_BOVIN reviewed Zinc finger FYVE domain-containing protein 26 ZFYVE26 Bos taurus (Bovine) 2515 cytokinesis [GO:0000910]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0000910; GO:0005765; GO:0005813; GO:0030496; GO:0032266; GO:0046872 0 0 0 PF01363; E9Q784 CHOYP_BRAFLDRAFT_120702.1.1 m.23852 sp ZC3HD_MOUSE 31.088 193 116 6 1446 1631 1546 1728 3.48E-21 105 ZC3HD_MOUSE reviewed Zinc finger CCCH domain-containing protein 13 Zc3h13 Mus musculus (Mouse) 1729 0 GO:0005654; GO:0016607; GO:0044822; GO:0046872 0 0 0 PF00642; F7H9X2 CHOYP_LOC100370588.9.19 m.32288 sp TRIM2_CALJA 23.837 344 165 11 6 325 11 281 3.48E-13 75.9 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O01814 CHOYP_FABP.1.2 m.51611 sp FABP5_CAEEL 32.09 134 84 5 3 136 5 131 3.48E-12 62.8 FABP5_CAEEL reviewed Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans 136 0 GO:0005215; GO:0005504; GO:0005634; GO:0048471 0 0 0 PF00061; O75382 CHOYP_LOC100904269.1.1 m.32558 sp TRIM3_HUMAN 25.628 199 121 7 172 361 523 703 3.48E-06 52.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O89113 CHOYP_LOC584505.1.1 m.40579 sp IER5_MOUSE 62.791 43 16 0 4 46 6 48 3.48E-09 60.5 IER5_MOUSE reviewed Immediate early response gene 5 protein Ier5 Mus musculus (Mouse) 308 0 GO:0042802 0 0 0 PF05760; P24733 CHOYP_MYS.2.7 m.2066 sp MYS_ARGIR 72.698 315 86 0 54 368 1448 1762 3.48E-147 462 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P35550 CHOYP_LOC591797.2.3 m.33687 sp FBRL_MOUSE 81.933 238 43 0 7 244 87 324 3.48E-148 419 FBRL_MOUSE reviewed rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Histone-glutamine methyltransferase) (Nucleolar protein 1) Fbl Mus musculus (Mouse) 327 box C/D snoRNA 3'-end processing [GO:0000494]; histone glutamine methylation [GO:1990258]; osteoblast differentiation [GO:0001649]; rRNA methylation [GO:0031167]; snoRNA localization [GO:0048254]; snoRNA metabolic process [GO:0016074]; tRNA processing [GO:0008033] GO:0000494; GO:0001094; GO:0001649; GO:0001651; GO:0001652; GO:0003723; GO:0005634; GO:0005730; GO:0008033; GO:0008649; GO:0015030; GO:0016020; GO:0016074; GO:0031167; GO:0031428; GO:0032040; GO:0044822; GO:0048254; GO:0051117; GO:0070062; GO:1990258; GO:1990259 0 0 0 PF01269; P60321 CHOYP_LOC100144352.1.1 m.10186 sp NANO2_HUMAN 57.407 54 23 0 156 209 63 116 3.48E-17 77.8 NANO2_HUMAN reviewed Nanos homolog 2 (NOS-2) NANOS2 NOS2 Homo sapiens (Human) 138 "cell differentiation [GO:0030154]; germ-line stem cell population maintenance [GO:0030718]; mRNA catabolic process [GO:0006402]; multicellular organism development [GO:0007275]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of translation [GO:0017148]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; spermatogenesis [GO:0007283]" GO:0000932; GO:0003729; GO:0005634; GO:0005737; GO:0006402; GO:0007275; GO:0007283; GO:0008270; GO:0017148; GO:0030154; GO:0030718; GO:0045835; GO:0048471; GO:1900153 0 0 0 PF05741; P61621 CHOYP_S61A1.1.3 m.52836 sp S61A1_RAT 51.606 467 221 2 1367 1830 2 466 3.48E-146 463 S61A1_RAT reviewed Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) Sec61a1 Sec61a Rattus norvegicus (Rat) 476 cell growth [GO:0016049]; endoplasmic reticulum organization [GO:0007029]; posttranslational protein targeting to membrane [GO:0006620]; response to interferon-gamma [GO:0034341]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005789; GO:0005791; GO:0006614; GO:0006620; GO:0007029; GO:0016021; GO:0016049; GO:0034341; GO:0043022 0 0 0 PF10559;PF00344; Q11130 CHOYP_CPIPJ_CPIJ006298.1.1 m.4762 sp FUT7_HUMAN 29.52 271 162 9 91 351 72 323 3.48E-26 110 FUT7_HUMAN reviewed "Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase) (Selectin ligand synthase)" FUT7 Homo sapiens (Human) 342 "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; leukocyte migration involved in immune response [GO:0002522]; L-fucose catabolic process [GO:0042355]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]" GO:0000139; GO:0002361; GO:0002522; GO:0005794; GO:0006486; GO:0006487; GO:0008417; GO:0016020; GO:0016021; GO:0032580; GO:0042355; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q17QS4 CHOYP_LOC100368871.1.1 m.58092 sp PI5L1_BOVIN 33.249 394 188 8 56 447 75 395 3.48E-65 217 PI5L1_BOVIN reviewed Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PI(4)P 5-kinase-like protein 1) (PtdIns(4)P-5-kinase-like protein 1) (EC 2.7.1.68) PIP5KL1 Bos taurus (Bovine) 396 0 GO:0005524; GO:0005737; GO:0016020; GO:0016308 0 0 0 PF01504; Q24372 CHOYP_LSAMP.1.1 m.36104 sp LACH_DROME 27.461 193 121 5 39 226 93 271 3.48E-14 75.5 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q5R1U3 CHOYP_LOC100493950.2.2 m.11543 sp CYTA3_DICDI 31.061 132 52 4 12 142 1 94 3.48E-11 58.9 CYTA3_DICDI reviewed Cystatin-A3 (VSA745) cpiC DDB_G0277001 Dictyostelium discoideum (Slime mold) 94 hyperosmotic response [GO:0006972]; proteolysis [GO:0006508] GO:0004869; GO:0005737; GO:0006508; GO:0006972 0 0 0 PF00031; Q5RD73 CHOYP_DUS3.1.1 m.25235 sp DUS3_PONAB 45.856 181 93 3 19 198 6 182 3.48E-48 158 DUS3_PONAB reviewed Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Vaccinia H1-related phosphatase) (VHR) DUSP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 185 dephosphorylation [GO:0016311]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of mitotic cell cycle [GO:0045931] GO:0001772; GO:0004725; GO:0005654; GO:0005829; GO:0008138; GO:0016311; GO:0016791; GO:0033549; GO:0045931; GO:0046329; GO:0050860; GO:0050868; GO:0070062; GO:0070373 0 0 0 PF00782; Q6H236 CHOYP_LOC757271.2.2 m.50608 sp PEG3_BOVIN 36.257 171 109 0 39 209 1283 1453 3.48E-12 68.9 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q80WR1 CHOYP_DWIL_GK16746.1.2 m.4760 sp TSN18_MOUSE 27.82 133 85 5 156 286 125 248 3.48E-11 65.5 TSN18_MOUSE reviewed Tetraspanin-18 (Tspan-18) Tspan18 Mus musculus (Mouse) 248 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q8AWF2 CHOYP_NACA.3.9 m.22497 sp NACA_ORENI 71.622 222 44 5 13 222 1 215 3.48E-85 254 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q8IV50 CHOYP_LOC100866180.1.1 m.49582 sp LYSM2_HUMAN 34.066 182 94 7 9 176 32 201 3.48E-17 79.7 LYSM2_HUMAN reviewed LysM and putative peptidoglycan-binding domain-containing protein 2 LYSMD2 Homo sapiens (Human) 215 0 0 0 0 0 PF01476; Q8JFY9 CHOYP_LOC100370026.1.1 m.42957 sp ENDUA_XENLA 49.817 273 128 7 55 321 11 280 3.48E-80 248 ENDUA_XENLA reviewed Poly(U)-specific endoribonuclease-A (EC 3.1.-.-) (Protein endoU-A) (Uridylate-specific endoribonuclease-A) (XendoU-A) endou-a Xenopus laevis (African clawed frog) 292 snoRNA processing [GO:0043144] GO:0003723; GO:0004521; GO:0005634; GO:0030145; GO:0043144 0 0 0 PF09412; Q8LQ68 CHOYP_GCK.1.2 m.4157 sp HXK6_ORYSJ 31.818 110 68 2 34 140 61 166 3.48E-08 55.8 HXK6_ORYSJ reviewed Hexokinase-6 (EC 2.7.1.1) (Hexokinase-2) HXK6 HXK2 Os01g0742500 LOC_Os01g53930 P0439E07.19 Oryza sativa subsp. japonica (Rice) 506 cellular glucose homeostasis [GO:0001678]; glycolytic process [GO:0006096]; response to glucose [GO:0009749] GO:0001678; GO:0004340; GO:0005524; GO:0005536; GO:0005739; GO:0005829; GO:0006096; GO:0008865; GO:0009707; GO:0009749; GO:0016021; GO:0019158 0 0 0 PF00349;PF03727; Q8WTV0 CHOYP_LOC583590.1.1 m.49388 sp SCRB1_HUMAN 36.102 313 191 5 4 310 3 312 3.48E-62 209 SCRB1_HUMAN reviewed "Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)" SCARB1 CD36L1 CLA1 Homo sapiens (Human) 552 adhesion of symbiont to host [GO:0044406]; androgen biosynthetic process [GO:0006702]; blood vessel endothelial cell migration [GO:0043534]; cholesterol catabolic process [GO:0006707]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; detection of lipopolysaccharide [GO:0032497]; endothelial cell proliferation [GO:0001935]; high-density lipoprotein particle clearance [GO:0034384]; high-density lipoprotein particle remodeling [GO:0034375]; intestinal absorption [GO:0050892]; lipopolysaccharide transport [GO:0015920]; lipoprotein metabolic process [GO:0042157]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; recognition of apoptotic cell [GO:0043654]; regulation of phagocytosis [GO:0050764]; regulation of phosphatidylcholine catabolic process [GO:0010899]; reverse cholesterol transport [GO:0043691]; triglyceride homeostasis [GO:0070328]; vitamin transmembrane transport [GO:0035461]; wound healing [GO:0042060] GO:0001530; GO:0001618; GO:0001786; GO:0001875; GO:0001935; GO:0005215; GO:0005545; GO:0005765; GO:0005886; GO:0005887; GO:0005901; GO:0006702; GO:0006707; GO:0006898; GO:0008035; GO:0009986; GO:0010595; GO:0010867; GO:0010886; GO:0010899; GO:0015914; GO:0015920; GO:0030169; GO:0030666; GO:0031528; GO:0032497; GO:0033344; GO:0034185; GO:0034186; GO:0034375; GO:0034383; GO:0034384; GO:0035461; GO:0042060; GO:0042157; GO:0042632; GO:0043231; GO:0043534; GO:0043654; GO:0043691; GO:0044406; GO:0050764; GO:0050892; GO:0051000; GO:0070062; GO:0070328; GO:0070506; GO:0070508 0 0 0 PF01130; Q94650 CHOYP_LOC100632440.1.1 m.676 sp ARF1_PLAFA 48 175 89 2 4 177 8 181 3.48E-55 177 ARF1_PLAFA reviewed ADP-ribosylation factor 1 (plARF) ARF1 ARF Plasmodium falciparum 181 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q9BH04 CHOYP_KBRS1.1.2 m.22578 sp KBRS1_MACFA 56.18 178 77 1 1 178 1 177 3.48E-70 214 KBRS1_MACFA reviewed NF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1) NKIRAS1 QflA-10220 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 192 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0007264; GO:0016020 0 0 0 PF00071; Q9BMX5 CHOYP_RS6.9.12 m.44799 sp RS6_APLCA 76.923 247 51 3 1 242 1 246 3.48E-132 375 RS6_APLCA reviewed 40S ribosomal protein S6 RPS6 Aplysia californica (California sea hare) 247 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01092; Q9CQM5 CHOYP_LOC100755189.1.1 m.33307 sp TXD17_MOUSE 53.719 121 54 1 3 123 5 123 3.48E-44 143 TXD17_MOUSE reviewed Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5) Txndc17 Txnl5 Mus musculus (Mouse) 123 tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004601; GO:0005829; GO:0033209; GO:0047134; GO:0070062 0 0 0 PF06110; Q9ESN6 CHOYP_LOC100373444.42.79 m.37534 sp TRIM2_MOUSE 26.484 219 137 8 347 553 536 742 3.48E-12 72.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC100376214.3.11 m.32701 sp TRIM2_MOUSE 27.397 219 128 8 63 267 536 737 3.48E-12 70.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAR2 CHOYP_CELSR2.1.2 m.25365 sp AGRL3_HUMAN 25.734 715 452 26 231 909 495 1166 3.48E-55 212 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; A2A3L6 CHOYP_RL10.1.3 m.11694 sp TTC24_HUMAN 33.943 383 236 9 14 391 36 406 3.49E-53 197 TTC24_HUMAN reviewed Tetratricopeptide repeat protein 24 (TPR repeat protein 24) TTC24 Homo sapiens (Human) 582 0 0 0 0 0 PF13176; A2ASS6 CHOYP_MYLK.1.4 m.1551 sp TITIN_MOUSE 31.41 156 92 2 20 175 7872 8012 3.49E-14 73.2 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A7M7B9 CHOYP_KPRB.1.1 m.17502 sp NTH_CHICK 62.151 251 88 2 42 291 35 279 3.49E-112 329 NTH_CHICK reviewed Endonuclease III-like protein 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycoslyase/AP lyase) NTHL1 Gallus gallus (Chicken) 281 "base-excision repair, AP site formation [GO:0006285]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792]" GO:0000703; GO:0002230; GO:0003690; GO:0005634; GO:0005739; GO:0006285; GO:0006296; GO:0046872; GO:0051539; GO:0098779; GO:0098792 0 0 cd00056; PF00633;PF00730; B3EWZ6 CHOYP_NEMVEDRAFT_V1G239043.4.6 m.21070 sp MLRP2_ACRMI 31.045 335 195 12 45 361 2278 2594 3.49E-35 140 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O28045 CHOYP_LOC100377996.1.1 m.43597 sp THSA_ARCFU 19.517 538 386 15 17 548 28 524 3.49E-24 109 THSA_ARCFU reviewed Thermosome subunit alpha (Chaperonin subunit alpha) (Thermosome subunit 1) thsA AF_2238 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) 545 protein folding [GO:0006457] GO:0005524; GO:0006457 0 0 cd03343; PF00118; P20069 CHOYP_PMPCA.1.1 m.40933 sp MPPA_RAT 56.034 116 49 2 24 138 30 144 3.49E-36 132 MPPA_RAT reviewed Mitochondrial-processing peptidase subunit alpha (EC 3.4.24.64) (Alpha-MPP) (P-55) Pmpca Mppa Rattus norvegicus (Rat) 524 protein processing involved in protein targeting to mitochondrion [GO:0006627]; proteolysis [GO:0006508] GO:0004175; GO:0004222; GO:0005743; GO:0005759; GO:0006508; GO:0006627; GO:0008270 0 0 0 PF00675;PF05193; P21328 CHOYP_RTJK.3.3 m.35967 sp RTJK_DROME 24.51 612 431 11 145 734 237 839 3.49E-49 192 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P24733 CHOYP_ISCW_ISCW001340.1.1 m.1979 sp MYS_ARGIR 68.732 339 105 1 1 339 979 1316 3.49E-122 391 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P28827 CHOYP_CAOG_00270.1.1 m.55160 sp PTPRM_HUMAN 28.974 604 388 16 574 1156 868 1451 3.49E-67 252 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P29227 CHOYP_contig_013326 m.15266 sp HP1_DROVI 50 56 23 2 201 251 24 79 3.49E-08 55.8 HP1_DROVI reviewed Heterochromatin protein 1 (HP1) HP1A HP1 Su(var)205 GJ17281 Drosophila virilis (Fruit fly) 213 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0016569 0 0 0 PF00385;PF01393; P29465 CHOYP_PHUM_PHUM073200.1.2 m.21846 sp CHS3_YEAST 35.556 180 98 6 23 185 831 1009 3.49E-20 94.7 CHS3_YEAST reviewed Chitin synthase 3 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 3) (Class-IV chitin synthase 3) CHS3 CAL1 CSD2 DIT101 KIT2 YBR023C YBR0305 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1165 ascospore wall assembly [GO:0030476]; fungal-type cell wall chitin biosynthetic process [GO:0034221] GO:0000131; GO:0004100; GO:0005628; GO:0005737; GO:0005886; GO:0005935; GO:0016021; GO:0030476; GO:0030659; GO:0034221; GO:0045009 0 0 0 0 P29691 CHOYP_EF2.1.5 m.1547 sp EF2_CAEEL 79.787 94 19 0 1 94 1 94 3.49E-46 161 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P42930 CHOYP_DPER_GL22446.1.1 m.52312 sp HSPB1_RAT 35.443 79 50 1 46 123 93 171 3.49E-06 47.8 HSPB1_RAT reviewed Heat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) Hspb1 Hsp27 Rattus norvegicus (Rat) 206 aging [GO:0007568]; cellular response to butyrate [GO:1903545]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-11 [GO:0071348]; female pregnancy [GO:0007565]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced cell death [GO:1903202]; positive regulation of neuron projection development [GO:0010976]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to muscle stretch [GO:0035994] GO:0000502; GO:0002931; GO:0005634; GO:0005737; GO:0005819; GO:0005886; GO:0007565; GO:0007568; GO:0010976; GO:0030424; GO:0030425; GO:0031430; GO:0031674; GO:0035994; GO:0043066; GO:0043130; GO:0043204; GO:0045202; GO:0070301; GO:0071348; GO:0097512; GO:0098839; GO:1903202; GO:1903545; GO:1990776 0 0 0 PF00011; P60897 CHOYP_LOC552741.2.5 m.9821 sp DSS1_MOUSE 79.104 67 13 1 26 92 3 68 3.49E-18 74.7 DSS1_MOUSE reviewed 26S proteasome complex subunit DSS1 (Deleted in split hand/split foot protein 1 homolog) (Split hand/foot deleted protein 1 homolog) (Split hand/foot malformation type 1 protein homolog) Shfm1 Dss1 Shfdg1 Mus musculus (Mouse) 70 double-strand break repair via homologous recombination [GO:0000724]; mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248]; proteolysis [GO:0006508] GO:0000502; GO:0000724; GO:0006406; GO:0006508; GO:0008541; GO:0043248 0 0 0 PF05160; P81623 CHOYP_ISCW_ISCW018425.1.1 m.35608 sp ERP29_BOVIN 41.256 223 122 8 101 318 33 251 3.49E-45 157 ERP29_BOVIN reviewed Endoplasmic reticulum resident protein 29 (ERp29) ERP29 Bos taurus (Bovine) 258 activation of MAPK activity [GO:0000187]; intracellular protein transport [GO:0006886]; negative regulation of gene expression [GO:0010629]; negative regulation of protein secretion [GO:0050709]; positive regulation of gene expression [GO:0010628]; protein folding [GO:0006457]; protein secretion [GO:0009306]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235] GO:0000187; GO:0005783; GO:0005788; GO:0006457; GO:0006886; GO:0009306; GO:0009986; GO:0010628; GO:0010629; GO:0016020; GO:0042470; GO:0050709; GO:0070062; GO:1902235 0 0 cd00238; PF07749;PF07912; Q02543 CHOYP_RL18A.4.8 m.42716 sp RL18A_HUMAN 71.25 160 46 0 17 176 1 160 3.49E-84 249 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q15643 CHOYP_TRIP11.2.2 m.38938 sp TRIPB_HUMAN 36.842 608 331 11 1641 2219 1394 1977 3.49E-95 348 TRIPB_HUMAN reviewed Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) TRIP11 CEV14 Homo sapiens (Human) 1979 protein targeting to Golgi [GO:0000042]; transcription from RNA polymerase II promoter [GO:0006366]; ventricular septum development [GO:0003281] GO:0000042; GO:0000139; GO:0002079; GO:0002081; GO:0003281; GO:0003713; GO:0005634; GO:0005794; GO:0005801; GO:0005856; GO:0006366; GO:0030133 0 0 0 0 Q24306 CHOYP_XIAP.6.7 m.60756 sp DIAP1_DROME 41 100 59 0 65 164 218 317 3.49E-20 96.7 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q25532 CHOYP_VATG.1.2 m.4407 sp VATG_MANSE 58.261 115 48 0 1 115 1 115 3.49E-40 132 VATG_MANSE reviewed V-type proton ATPase subunit G (V-ATPase subunit G) (V-ATPase 13 kDa subunit) (Vacuolar proton pump subunit G) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 117 proton transport [GO:0015992] GO:0015992; GO:0016324; GO:0016471; GO:0016820 0 0 0 0 Q29611 CHOYP_CLN3.2.2 m.60235 sp CLN3_CANLF 47.525 404 210 2 6 407 35 438 3.49E-128 379 CLN3_CANLF reviewed Battenin (Protein CLN3) CLN3 Canis lupus familiaris (Dog) (Canis familiaris) 438 amyloid precursor protein catabolic process [GO:0042987]; arginine transport [GO:0015809]; ceramide metabolic process [GO:0006672]; galactosylceramide metabolic process [GO:0006681]; globoside metabolic process [GO:0001575]; glucosylceramide metabolic process [GO:0006678]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; negative regulation of apoptotic process [GO:0043066]; receptor-mediated endocytosis [GO:0006898]; sphingomyelin metabolic process [GO:0006684]; vacuolar transport [GO:0007034]; vesicle transport along microtubule [GO:0047496] GO:0000139; GO:0001575; GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005783; GO:0005794; GO:0005795; GO:0005802; GO:0005886; GO:0005901; GO:0006672; GO:0006678; GO:0006681; GO:0006684; GO:0006898; GO:0007034; GO:0007042; GO:0008021; GO:0015809; GO:0016021; GO:0030176; GO:0031301; GO:0035752; GO:0042987; GO:0043005; GO:0043066; GO:0045121; GO:0047496 0 0 0 PF02487; Q5R662 CHOYP_RIOK3.1.1 m.54196 sp LRP12_PONAB 26.316 152 83 4 26 170 68 197 3.49E-06 52 LRP12_PONAB reviewed Low-density lipoprotein receptor-related protein 12 (LRP-12) LRP12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 859 endocytosis [GO:0006897] GO:0005887; GO:0005905; GO:0006897 0 0 0 PF00431;PF00057; Q68CP9 CHOYP_ARID2.2.2 m.44733 sp ARID2_HUMAN 37.321 627 360 8 1 611 1 610 3.49E-129 450 ARID2_HUMAN reviewed AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) ARID2 KIAA1557 Homo sapiens (Human) 1835 "covalent chromatin modification [GO:0016569]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005654; GO:0005886; GO:0006337; GO:0006351; GO:0006355; GO:0008285; GO:0016569; GO:0030336; GO:0046872; GO:0090544 0 0 0 PF01388;PF02257; Q6WV88 CHOYP_LOC100533458.1.1 m.11525 sp H2A_MYTGA 98.333 120 2 0 14 133 1 120 3.49E-80 235 H2A_MYTGA reviewed Histone H2A 0 Mytilus galloprovincialis (Mediterranean mussel) 125 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125;PF16211; Q86UP9 CHOYP_LOC578003.1.1 m.64330 sp LHPL3_HUMAN 42.202 218 125 1 8 225 20 236 3.49E-57 186 LHPL3_HUMAN reviewed Lipoma HMGIC fusion partner-like 3 protein LHFPL3 LHFPL4 Homo sapiens (Human) 236 0 GO:0016021 0 0 0 PF10242; Q8CHG3 CHOYP_GCC2.1.1 m.17251 sp GCC2_MOUSE 31.44 1250 694 32 958 2133 518 1678 3.49E-107 384 GCC2_MOUSE reviewed GRIP and coiled-coil domain-containing protein 2 (185 kDa Golgi coiled-coil protein) (GCC185) Gcc2 Kiaa0336 Mus musculus (Mouse) 1679 "Golgi ribbon formation [GO:0090161]; late endosome to Golgi transport [GO:0034499]; microtubule anchoring [GO:0034453]; microtubule organizing center organization [GO:0031023]; protein localization to Golgi apparatus [GO:0034067]; protein targeting to Golgi [GO:0000042]; protein targeting to lysosome [GO:0006622]; recycling endosome to Golgi transport [GO:0071955]; regulation of protein exit from endoplasmic reticulum [GO:0070861]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000042; GO:0005794; GO:0005802; GO:0005829; GO:0006622; GO:0016020; GO:0031023; GO:0034067; GO:0034453; GO:0034499; GO:0042147; GO:0042802; GO:0070861; GO:0071955; GO:0090161 0 0 0 PF01465;PF16704; Q8TC29 CHOYP_BRAFLDRAFT_125432.1.1 m.50346 sp ENKUR_HUMAN 54.971 171 77 0 103 273 84 254 3.49E-65 207 ENKUR_HUMAN reviewed Enkurin ENKUR C10orf63 Homo sapiens (Human) 256 0 GO:0001669; GO:0097228 0 0 0 PF13864; Q9D9M5 CHOYP_LOC100559885.1.1 m.50207 sp PHOP2_MOUSE 37.705 244 143 3 37 278 2 238 3.49E-58 189 PHOP2_MOUSE reviewed Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74) Phospho2 Mus musculus (Mouse) 241 0 GO:0016791; GO:0033883; GO:0046872 0 0 0 PF06888; Q9H3P7 CHOYP_BRAFLDRAFT_278625.1.2 m.53120 sp GCP60_HUMAN 51.398 465 190 5 44 487 79 528 3.49E-103 321 GCP60_HUMAN reviewed "Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi complex-associated protein 1) (GOCAP1) (Golgi phosphoprotein 1) (GOLPH1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]" ACBD3 GCP60 GOCAP1 GOLPH1 Homo sapiens (Human) 528 steroid biosynthetic process [GO:0006694]; transport [GO:0006810] GO:0000062; GO:0000139; GO:0005739; GO:0005794; GO:0006694; GO:0006810; GO:0016020; GO:0016021; GO:0034237 0 0 0 PF00887;PF13897; Q9JLZ3 CHOYP_AUHM.1.2 m.28847 sp AUHM_MOUSE 68.889 135 42 0 1 135 180 314 3.49E-63 198 AUHM_MOUSE reviewed "Methylglutaconyl-CoA hydratase, mitochondrial (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH)" Auh Mus musculus (Mouse) 314 "branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation [GO:0006635]; leucine catabolic process [GO:0006552]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]" GO:0000288; GO:0003723; GO:0003730; GO:0004300; GO:0004490; GO:0005739; GO:0006552; GO:0006635; GO:0009083 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3. 0 0 PF00378; Q9UJV3 CHOYP_BRAFLDRAFT_93989.2.5 m.17070 sp TRIM1_HUMAN 23.163 449 273 15 13 412 23 448 3.49E-18 92.4 TRIM1_HUMAN reviewed Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (Tripartite motif-containing protein 1) MID2 FXY2 RNF60 TRIM1 Homo sapiens (Human) 735 innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567] GO:0005737; GO:0005874; GO:0008017; GO:0008270; GO:0010508; GO:0016567; GO:0016874; GO:0032897; GO:0035372; GO:0042803; GO:0043123; GO:0045087; GO:0046597; GO:0046982; GO:0051091; GO:0051092; GO:0051219; GO:0070062; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622;PF00643;PF13445; Q9W0E8 CHOYP_LOC659004.1.1 m.34730 sp ZER1_DROME 37.845 798 414 16 10 750 17 789 3.49E-160 486 ZER1_DROME reviewed Protein zer-1 homolog (Zyg-11 homolog B-like protein) CG12084 Drosophila melanogaster (Fruit fly) 793 regulation of ubiquitin-protein transferase activity [GO:0051438] GO:0004842; GO:0031462; GO:0051438 0 0 0 0 Q9Y6R7 CHOYP_CYCMA_4408.3.3 m.27097 sp FCGBP_HUMAN 22.052 458 308 15 323 766 4 426 3.49E-11 71.2 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; G5EBF1 CHOYP_LOC100707926.1.4 m.40762 sp SAX3_CAEEL 33.108 148 82 7 177 323 186 317 3.50E-09 62 SAX3_CAEEL reviewed Protein sax-3 (Sensory axon guidance 3) sax-3 ZK377.2 Caenorhabditis elegans 1273 dorsal/ventral axon guidance [GO:0033563]; neuron migration [GO:0001764]; Roundabout signaling pathway [GO:0035385] GO:0001764; GO:0005887; GO:0008046; GO:0033563; GO:0035385 0 0 0 PF00041;PF07679; O15439 CHOYP_MRP4.3.3 m.47440 sp MRP4_HUMAN 57.721 272 115 0 1 272 1007 1278 3.50E-104 333 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; P07192 CHOYP_BRAFLDRAFT_220425.2.4 m.10661 sp MAL3_DROME 36.699 515 286 13 1 491 76 574 3.50E-105 328 MAL3_DROME reviewed Maltase A3 (EC 3.2.1.20) (Larval visceral protein L) Mal-A3 LvpL CG8695 Drosophila melanogaster (Fruit fly) 574 0 GO:0004558; GO:0032450 0 0 0 PF00128; P51006 CHOYP_PAPOLA.1.1 m.5865 sp PAPO3_XENLA 59.732 149 57 1 34 182 18 163 3.50E-57 187 PAPO3_XENLA reviewed Poly(A) polymerase type 3 (PAP) (EC 2.7.7.19) (Polynucleotide adenylyltransferase) (Fragment) 0 Xenopus laevis (African clawed frog) 400 mRNA processing [GO:0006397]; RNA polyadenylation [GO:0043631] GO:0003723; GO:0004652; GO:0005524; GO:0005634; GO:0006397; GO:0043631; GO:0046872 0 0 0 PF01909;PF04928; P62752 CHOYP_LOC100179448.1.1 m.8296 sp RL23A_RAT 73.148 108 29 0 49 156 31 138 3.50E-49 158 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P83425 CHOYP_LOC100702077.1.1 m.29720 sp HIP_MYTED 32.609 138 82 3 163 298 85 213 3.50E-10 62 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P87158 CHOYP_BRAFLDRAFT_215239.2.3 m.22661 sp RS4A_SCHPO 75.676 74 18 0 1 74 66 139 3.50E-36 127 RS4A_SCHPO reviewed 40S ribosomal protein S4-A rps401 rps4 rps4a SPBC19F8.08 SPBC25H2.17c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 262 translation [GO:0006412] GO:0003735; GO:0005829; GO:0006412; GO:0019843; GO:0022627 0 0 0 PF16121;PF00900;PF08071;PF01479; Q06033 CHOYP_ITIH3.2.3 m.22992 sp ITIH3_HUMAN 33.122 631 341 19 2 596 304 889 3.50E-83 281 ITIH3_HUMAN reviewed Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP) ITIH3 Homo sapiens (Human) 890 hyaluronan metabolic process [GO:0030212]; platelet degranulation [GO:0002576] GO:0002576; GO:0004866; GO:0004867; GO:0005576; GO:0030212; GO:0031089; GO:0070062 0 0 0 PF06668;PF08487;PF00092; Q0VFR9 CHOYP_MED17.1.1 m.1678 sp MED17_XENTR 46.401 653 307 18 19 650 7 637 3.50E-178 524 MED17_XENTR reviewed Mediator of RNA polymerase II transcription subunit 17 (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) med17 crsp6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 639 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592 0 0 0 PF10156; Q13393 CHOYP_PLD1.1.1 m.57889 sp PLD1_HUMAN 46.778 481 238 10 885 1359 605 1073 3.50E-129 429 PLD1_HUMAN reviewed Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) PLD1 Homo sapiens (Human) 1074 cell motility [GO:0048870]; chemotaxis [GO:0006935]; inositol lipid-mediated signaling [GO:0048017]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0004630; GO:0005765; GO:0005768; GO:0005789; GO:0005794; GO:0006654; GO:0006935; GO:0007264; GO:0007265; GO:0016020; GO:0016042; GO:0016324; GO:0030139; GO:0031902; GO:0032534; GO:0035091; GO:0048017; GO:0048471; GO:0048870; GO:0070290 0 0 0 PF00169;PF00614;PF13091;PF00787; Q2TAL6 CHOYP_KCP.11.13 m.46010 sp VWC2_HUMAN 35.238 105 63 4 43 143 218 321 3.50E-11 62.8 VWC2_HUMAN reviewed Brorin (Brain-specific chordin-like protein) (von Willebrand factor C domain-containing protein 2) VWC2 UNQ739/PRO1434 Homo sapiens (Human) 325 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666] GO:0005604; GO:0005614; GO:0005615; GO:0010811; GO:0030054; GO:0030514; GO:0032281; GO:0045202; GO:0045666 0 0 0 PF00093; Q2YDJ8 CHOYP_contig_033662 m.38287 sp KMT5A_BOVIN 29.661 118 64 4 2 102 234 349 3.50E-10 59.3 KMT5A_BOVIN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A SETD8 Bos taurus (Bovine) 352 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0005634; GO:0005694; GO:0006351; GO:0007067; GO:0016279; GO:0018024; GO:0018026; GO:0043516; GO:0051301 0 0 0 PF00856; Q49A88 CHOYP_BRAFLDRAFT_122721.1.1 m.9910 sp CCD14_HUMAN 28.889 225 158 2 531 754 431 654 3.50E-19 97.4 CCD14_HUMAN reviewed Coiled-coil domain-containing protein 14 CCDC14 Homo sapiens (Human) 953 protein localization to centrosome [GO:0071539]; substantia nigra development [GO:0021762] GO:0005813; GO:0021762; GO:0034451; GO:0071539 0 0 0 PF15254; Q58A42 CHOYP_BRAFLDRAFT_120072.1.1 m.3963 sp DD3_DICDI 37.908 612 294 17 17 593 15 575 3.50E-114 362 DD3_DICDI reviewed Protein DD3-3 DD3-3 DDB_G0283095 Dictyostelium discoideum (Slime mold) 616 0 GO:0016021 0 0 0 0 Q5TYP8 CHOYP_CA095.1.1 m.62506 sp STUM_DANRE 49.074 108 51 2 22 127 23 128 3.50E-24 93.6 STUM_DANRE reviewed Protein stum homolog si:dkeyp-59a8.4 Danio rerio (Zebrafish) (Brachydanio rerio) 128 0 GO:0016021 0 0 0 PF15795; Q6P823 CHOYP_H33.5.5 m.66562 sp H33_XENTR 99.265 136 1 0 1 136 1 136 3.50E-94 270 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q6R7H8 CHOYP_Y047.1.1 m.27089 sp Y046_OSHVF 100 215 0 0 1 215 1 215 3.50E-160 444 Y046_OSHVF reviewed Uncharacterized protein ORF46 ORF46 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 215 0 0 0 0 0 0 Q6ZPS2 CHOYP_DWIL_GK23042.1.1 m.38793 sp CRNS1_MOUSE 64.912 114 40 0 1 114 599 712 3.50E-47 167 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q7YW31 CHOYP_CTR1.3.4 m.40226 sp CTR1_OCTVU 52.201 159 76 0 9 167 26 184 3.50E-52 174 CTR1_OCTVU reviewed Cephalotocin receptor 1 (OC/CE-R 1) (OT/VP superfamily peptide receptor 1) CTR1 Octopus vulgaris (Common octopus) 397 G-protein coupled receptor signaling pathway [GO:0007186] GO:0005000; GO:0005886; GO:0007186; GO:0016021; GO:0016500 0 0 0 PF00001; Q7ZWA3 CHOYP_RBMX.1.1 m.26723 sp RBMX_DANRE 55.556 90 40 0 4 93 2 91 3.50E-27 118 RBMX_DANRE reviewed "RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G)" rbmx Danio rerio (Zebrafish) (Brachydanio rerio) 379 "cellular response to interleukin-1 [GO:0071347]; membrane protein ectodomain proteolysis [GO:0006509]; mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000166; GO:0000381; GO:0001047; GO:0003682; GO:0003723; GO:0003729; GO:0005634; GO:0005719; GO:0006366; GO:0006397; GO:0006509; GO:0007275; GO:0008380; GO:0044530; GO:0045944; GO:0048025; GO:0048026; GO:0051260; GO:0070062; GO:0071013; GO:0071347 0 0 0 PF08081;PF00076; Q8R2R5 CHOYP_LRRC61.1.1 m.46305 sp LRC61_MOUSE 42.918 233 132 1 22 254 16 247 3.50E-54 178 LRC61_MOUSE reviewed Leucine-rich repeat-containing protein 61 Lrrc61 Mus musculus (Mouse) 259 0 0 0 0 0 0 Q8WZ42 CHOYP_SLS.1.1 m.41055 sp TITIN_HUMAN 32.624 141 94 1 81 221 1439 1578 3.50E-15 80.9 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q92752 CHOYP_TNC.1.1 m.19747 sp TENR_HUMAN 30.827 133 63 8 44 149 188 318 3.50E-07 52.8 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q96RW7 CHOYP_BM1_12515.3.7 m.36978 sp HMCN1_HUMAN 25.062 403 255 17 242 632 4019 4386 3.50E-08 62.4 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99JL1 CHOYP_LOC100371058.2.3 m.22727 sp SPEF1_MOUSE 39.167 240 128 3 18 257 1 222 3.50E-46 157 SPEF1_MOUSE reviewed Sperm flagellar protein 1 Spef1 Mus musculus (Mouse) 234 0 GO:0005737; GO:0005930; GO:0031514 0 0 0 PF06294; Q9BT81 CHOYP_SOX18.1.1 m.4791 sp SOX7_HUMAN 62.105 95 36 0 26 120 26 120 3.50E-34 130 SOX7_HUMAN reviewed Transcription factor SOX-7 SOX7 Homo sapiens (Human) 388 "endoderm formation [GO:0001706]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; regulation of canonical Wnt signaling pathway [GO:0060828]; transcription, DNA-templated [GO:0006351]" GO:0001706; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0008285; GO:0043280; GO:0044212; GO:0045892; GO:0060828 0 0 0 PF00505;PF12067; Q9N1T2 CHOYP_TRIADDRAFT_56257.1.1 m.7863 sp RPGR_CANLF 43.125 480 233 12 14 476 8 464 3.50E-114 373 RPGR_CANLF reviewed X-linked retinitis pigmentosa GTPase regulator RPGR Canis lupus familiaris (Dog) (Canis familiaris) 1003 cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005085; GO:0005794; GO:0005813; GO:0007601; GO:0036064; GO:0036126; GO:0042073; GO:0042384; GO:0050896 0 0 0 PF00415; Q9V9Z1 CHOYP_DSEC_GM12928.1.1 m.11933 sp RM32_DROME 31.016 187 111 8 4 172 9 195 3.50E-09 57 RM32_DROME reviewed "39S ribosomal protein L32, mitochondrial (L32mt) (MRP-L32)" mRpL32 CG12220 Drosophila melanogaster (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0005743; GO:0005762; GO:0006412 0 0 0 0 A0JM12 CHOYP_CED1.9.29 m.29470 sp MEG10_XENTR 34.426 122 75 2 89 207 611 730 3.51E-13 71.2 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; O55043 CHOYP_ARHG7.4.5 m.50588 sp ARHG7_RAT 45.578 147 45 3 5 147 529 644 3.51E-27 108 ARHG7_RAT reviewed Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) Arhgef7 Pak3bp Pixb Rattus norvegicus (Rat) 646 astrocyte cell migration [GO:0043615]; lamellipodium assembly [GO:0030032]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264] GO:0001726; GO:0005085; GO:0005089; GO:0005737; GO:0005925; GO:0005938; GO:0007264; GO:0019901; GO:0030027; GO:0030032; GO:0030426; GO:0035023; GO:0043065; GO:0043615 0 0 0 PF16523;PF00169;PF00621;PF07653; O57592 CHOYP_LOC100366813.4.6 m.31116 sp RL7A_TAKRU 77.551 196 41 2 27 222 16 208 3.51E-108 315 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O70277 CHOYP_LOC101062597.1.1 m.37596 sp TRIM3_RAT 29.268 164 85 8 38 186 578 725 3.51E-06 49.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75096 CHOYP_LOC578656.11.15 m.54319 sp LRP4_HUMAN 25.592 887 588 24 113 965 516 1364 3.51E-87 315 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; P21328 CHOYP_LOC752194.12.12 m.65028 sp RTJK_DROME 24.516 310 219 8 18 320 583 884 3.51E-14 79 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P27393 CHOYP_COLA1.1.1 m.27002 sp CO4A2_ASCSU 46.287 404 173 8 99 477 1077 1461 3.51E-48 187 CO4A2_ASCSU reviewed Collagen alpha-2(IV) chain 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 1763 0 GO:0005201; GO:0005581; GO:0005604 0 0 0 PF01413;PF01391; P28827 CHOYP_LOC100927395.1.1 m.60822 sp PTPRM_HUMAN 38.255 298 178 2 407 700 849 1144 3.51E-58 218 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P31597 CHOYP_EAA3.1.1 m.38101 sp EAA3_RABIT 51.389 504 217 9 18 518 12 490 3.51E-171 496 EAA3_RABIT reviewed Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 Oryctolagus cuniculus (Rabbit) 524 cysteine transport [GO:0042883]; D-aspartate import [GO:0070779]; L-glutamate transmembrane transport [GO:0089711] GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0016324; GO:0033229; GO:0042883; GO:0070779; GO:0089711 0 0 0 PF00375; P35590 CHOYP_ZGC_158328.1.2 m.33524 sp TIE1_HUMAN 29.508 122 62 6 19 140 237 334 3.51E-10 62 TIE1_HUMAN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) 1138 angiogenesis [GO:0001525]; in utero embryonic development [GO:0001701]; mesoderm development [GO:0007498]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] GO:0001525; GO:0001570; GO:0001701; GO:0004714; GO:0005524; GO:0005887; GO:0007165; GO:0007498; GO:0016525; GO:0030336; GO:0032526; GO:0045026 0 0 0 PF00041;PF00047;PF07714; P39963 CHOYP_CCNB3.1.1 m.6285 sp CCNB3_CHICK 47.838 370 155 6 7 368 49 388 3.51E-106 321 CCNB3_CHICK reviewed G2/mitotic-specific cyclin-B3 CCNB3 CYCB3 Gallus gallus (Chicken) 403 cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of G2/M transition of mitotic cell cycle [GO:0010389] GO:0000079; GO:0005634; GO:0007049; GO:0010389; GO:0051301 0 0 0 PF02984;PF00134; P51989 CHOYP_LOC100748395.6.7 m.57994 sp RO21_XENLA 53.886 193 89 0 42 234 4 196 3.51E-67 217 RO21_XENLA reviewed Heterogeneous nuclear ribonucleoprotein A2 homolog 1 (hnRNP A2(A)) 0 Xenopus laevis (African clawed frog) 346 0 GO:0000166; GO:0003723; GO:0005634; GO:0030529 0 0 0 PF00076; P56101 CHOYP_DNJC5.1.1 m.52453 sp DNJC5_TETCF 55.721 201 75 4 3 202 5 192 3.51E-56 180 DNJC5_TETCF reviewed DnaJ homolog subfamily C member 5 (CCCS1) (Cysteine string protein) (CSP) dnajc5 Tetronarce californica (Pacific electric ray) (Torpedo californica) 195 0 GO:0016020 0 0 cd06257; PF00226; Q04831 CHOYP_GLNA.3.5 m.18489 sp GLNA_PANAR 69.675 277 84 0 1 277 1 277 3.51E-148 422 GLNA_PANAR reviewed Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) 0 Panulirus argus (Caribbean spiny lobster) (Palinurus argus) 361 glutamine biosynthetic process [GO:0006542] GO:0004356; GO:0005524; GO:0005737; GO:0006542 0 0 0 PF00120;PF03951; Q2YDF6 CHOYP_MRPS35.1.1 m.20118 sp RT35_BOVIN 42.123 292 156 5 67 357 45 324 3.51E-74 235 RT35_BOVIN reviewed "28S ribosomal protein S35, mitochondrial (MRP-S35) (S35mt) (28S ribosomal protein S28, mitochondrial) (MRP-S28) (S28mt)" MRPS35 MRPS28 Bos taurus (Bovine) 325 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005763; GO:0032543; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF10213; Q3TRR0 CHOYP_contig_010246 m.11935 sp MAP9_MOUSE 37.662 231 123 10 562 782 423 642 3.51E-16 86.3 MAP9_MOUSE reviewed Microtubule-associated protein 9 (Aster-associated protein) Map9 Asap Mtap9 Mus musculus (Mouse) 646 cytokinesis [GO:0000910]; mitotic spindle assembly [GO:0090307]; regulation of mitotic nuclear division [GO:0007088] GO:0000910; GO:0005737; GO:0005818; GO:0005874; GO:0007088; GO:0015630; GO:0090307; GO:1990023 0 0 0 0 Q4QQM4 CHOYP_TP53I11.1.2 m.2783 sp P5I11_MOUSE 41.899 179 102 2 53 229 9 187 3.51E-40 139 P5I11_MOUSE reviewed Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) 189 0 GO:0016021 0 0 0 PF14936; Q4R8M9 CHOYP_BRAFLDRAFT_277055.2.2 m.18713 sp GTSF1_MACFA 53.191 47 20 1 3 47 32 78 3.51E-11 63.5 GTSF1_MACFA reviewed Gametocyte-specific factor 1 (Protein FAM112B) GTSF1 FAM112B QtsA-12026 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 167 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0005737; GO:0007283; GO:0030154; GO:0046872 0 0 0 PF05253; Q4V887 CHOYP_S39AA.1.3 m.18874 sp S39A6_RAT 31.412 694 329 21 69 632 60 736 3.51E-83 280 S39A6_RAT reviewed Zinc transporter ZIP6 (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) Slc39a6 Zip6 Rattus norvegicus (Rat) 741 cellular zinc ion homeostasis [GO:0006882]; zinc II ion transmembrane import [GO:0071578]; zinc II ion transmembrane transport [GO:0071577] GO:0005385; GO:0005783; GO:0005886; GO:0005887; GO:0006882; GO:0009986; GO:0031258; GO:0071577; GO:0071578 0 0 0 PF02535; Q62770 CHOYP_NEMVEDRAFT_V1G210604.2.8 m.10056 sp UN13C_RAT 28.931 159 97 5 120 263 244 401 3.51E-07 55.8 UN13C_RAT reviewed Protein unc-13 homolog C (Munc13-3) Unc13c Unc13h3 Rattus norvegicus (Rat) 2204 chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556]; regulation of neurotransmitter secretion [GO:0046928] GO:0005737; GO:0005886; GO:0006887; GO:0007268; GO:0019992; GO:0030054; GO:0035556; GO:0042734; GO:0046872; GO:0046928 0 0 0 PF00130;PF00168;PF06292;PF10540; Q66IC8 CHOYP_TCTEX1D1.1.2 m.54865 sp TC1D1_DANRE 41.304 138 75 2 88 220 37 173 3.51E-28 107 TC1D1_DANRE reviewed Tctex1 domain-containing protein 1 tctex1d1 zgc:101774 Danio rerio (Zebrafish) (Brachydanio rerio) 173 0 0 0 0 0 PF03645; Q8BZ20 CHOYP_PAR15.2.6 m.21082 sp PAR12_MOUSE 34.532 139 71 6 308 441 566 689 3.51E-12 72 PAR12_MOUSE reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) 711 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q8BZ25 CHOYP_ANK2.6.8 m.52796 sp ANKK1_MOUSE 32.493 357 240 1 31 386 384 740 3.51E-53 191 ANKK1_MOUSE reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) 745 0 GO:0004674; GO:0005524 0 0 0 PF00023;PF12796;PF07714; Q8CI17 CHOYP_NEMVEDRAFT_V1G218914.4.4 m.62116 sp MB213_MOUSE 23.636 165 112 4 77 235 263 419 3.51E-06 53.1 MB213_MOUSE reviewed Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) 429 0 0 0 0 0 PF03281; Q8NDA2 CHOYP_LOC100149247.1.1 m.513 sp HMCN2_HUMAN 25.604 207 124 9 242 436 2908 3096 3.51E-09 63.2 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8TC12 CHOYP_DANA_GF13192.1.1 m.49620 sp RDH11_HUMAN 38.246 285 160 6 68 345 39 314 3.51E-42 152 RDH11_HUMAN reviewed Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1) RDH11 ARSDR1 PSDR1 SDR7C1 CGI-82 Homo sapiens (Human) 318 adaptation of rhodopsin mediated signaling [GO:0016062]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572] GO:0001523; GO:0001917; GO:0004745; GO:0005622; GO:0005789; GO:0016021; GO:0016062; GO:0016616; GO:0042572; GO:0042574; GO:0052650 0 0 0 PF00106; Q923W1 CHOYP_TGS1.1.2 m.14304 sp TGS1_MOUSE 37.019 624 296 18 376 919 232 838 3.51E-102 342 TGS1_MOUSE reviewed Trimethylguanosine synthase (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Tgs1 Ncoa6ip Pimt Mus musculus (Mouse) 853 "7-methylguanosine cap hypermethylation [GO:0036261]; 7-methylguanosine RNA capping [GO:0009452]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005615; GO:0005634; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0009452; GO:0015030; GO:0036261; GO:0071164 0 0 0 PF09445; Q92851 CHOYP_LOC795066.2.3 m.35570 sp CASPA_HUMAN 32.203 177 86 6 14 170 280 442 3.51E-14 78.2 CASPA_HUMAN reviewed Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005829; GO:0006915; GO:0007166; GO:0008625; GO:0030225; GO:0031265; GO:0031625; GO:0035877; GO:0042981; GO:0043123; GO:0097190; GO:0097199; GO:0097342 0 0 0 PF01335; Q96AE7 CHOYP_BRAFLDRAFT_231915.1.1 m.37818 sp TTC17_HUMAN 38.701 739 399 16 322 1032 38 750 3.51E-149 490 TTC17_HUMAN reviewed Tetratricopeptide repeat protein 17 (TPR repeat protein 17) TTC17 Homo sapiens (Human) 1141 actin filament polymerization [GO:0030041]; cilium organization [GO:0044782] GO:0005737; GO:0005886; GO:0015629; GO:0030041; GO:0044782 0 0 0 PF13181; Q98943 CHOYP_TRIADDRAFT_60922.1.2 m.56977 sp CASP2_CHICK 33.333 105 70 0 953 1057 6 110 3.51E-09 63.9 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q99323 CHOYP_ZIP.1.1 m.15785 sp MYSN_DROME 63.842 354 90 4 1 316 46 399 3.51E-148 462 MYSN_DROME reviewed "Myosin heavy chain, non-muscle (Myosin II) (Non-muscle MHC) (Zipper protein)" zip CG15792 Drosophila melanogaster (Fruit fly) 2057 "anterior midgut development [GO:0007496]; border follicle cell migration [GO:0007298]; cellular response to mechanical stimulus [GO:0071260]; cuticle pattern formation [GO:0035017]; dorsal closure [GO:0007391]; dorsal closure, amnioserosa morphology change [GO:0046664]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; establishment of neuroblast polarity [GO:0045200]; establishment of planar polarity [GO:0001736]; head involution [GO:0008258]; imaginal disc-derived wing hair organization [GO:0035317]; left/right axis specification [GO:0070986]; maintenance of protein location in cell [GO:0032507]; Malpighian tubule morphogenesis [GO:0007443]; mitotic cytokinesis [GO:0000281]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; myosin II filament assembly [GO:0031036]; neurogenesis [GO:0022008]; ovarian follicle cell migration [GO:0007297]; protein oligomerization [GO:0051259]; regulation of cell cycle [GO:0051726]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; sarcomere organization [GO:0045214]; spiracle morphogenesis, open tracheal system [GO:0035277]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0003774; GO:0005524; GO:0005829; GO:0005856; GO:0005938; GO:0006936; GO:0007297; GO:0007298; GO:0007391; GO:0007395; GO:0007435; GO:0007443; GO:0007496; GO:0008258; GO:0016459; GO:0016460; GO:0016461; GO:0022008; GO:0030018; GO:0030239; GO:0031036; GO:0031252; GO:0032027; GO:0032154; GO:0032507; GO:0035017; GO:0035159; GO:0035277; GO:0035317; GO:0042060; GO:0042623; GO:0044291; GO:0045179; GO:0045200; GO:0045214; GO:0046663; GO:0046664; GO:0051259; GO:0051726; GO:0070986; GO:0071260; GO:1901739 0 0 0 PF00612;PF00063;PF02736;PF01576; Q99489 CHOYP_OXDD.3.4 m.48078 sp OXDD_HUMAN 43.519 324 176 5 2 321 4 324 3.51E-88 270 OXDD_HUMAN reviewed D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Homo sapiens (Human) 341 aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; glyoxylate metabolic process [GO:0046487]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insemination [GO:0007320] GO:0005102; GO:0005777; GO:0005782; GO:0006531; GO:0006533; GO:0007320; GO:0007625; GO:0008445; GO:0019478; GO:0042445; GO:0046487; GO:0048037; GO:0071949 0 0 0 PF01266; Q9NLA3 CHOYP_CATA.3.3 m.21643 sp ANO39_PATPE 38.983 118 66 1 5 116 1 118 3.51E-19 87.8 ANO39_PATPE reviewed Nucleoplasmin-like protein ANO39 (39 kDa oocyte-expressed nucleolar protein) (Nucleic acid-associated protein 36) (Nucleic acid-binding nuclear protein) (NAAP) (NAAP1) (NAAP2) 0 Patiria pectinifera (Starfish) (Asterina pectinifera) 346 mitotic nuclear division [GO:0007067]; oocyte maturation [GO:0001556] GO:0001556; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0007067 0 0 0 PF16276;PF03066; A8WG43 CHOYP_LOC100368248.1.1 m.66190 sp CCD89_DANRE 42.623 366 187 7 14 370 1 352 3.52E-72 231 CCD89_DANRE reviewed Coiled-coil domain-containing protein 89 (Bc8 orange-interacting protein) ccdc89 boip zgc:172182 Danio rerio (Zebrafish) (Brachydanio rerio) 354 0 GO:0005634; GO:0005737 0 0 0 0 D8VNT0 CHOYP_BRAFLDRAFT_86061.7.13 m.50940 sp FCNV4_CERRY 47.938 194 96 3 93 284 128 318 3.52E-60 197 FCNV4_CERRY reviewed Ryncolin-4 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; O15050 CHOYP_TRNK1.2.6 m.57037 sp TRNK1_HUMAN 34.739 593 352 12 1 592 1517 2075 3.52E-89 306 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O17966 CHOYP_LOC101160732.1.1 m.29713 sp TOP1_CAEEL 37.231 325 137 4 56 313 481 805 3.52E-59 206 TOP1_CAEEL reviewed DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) (topoI) top-1 M01E5.5 Caenorhabditis elegans 806 chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; DNA replication [GO:0006260]; DNA topological change [GO:0006265] GO:0003677; GO:0003917; GO:0003918; GO:0005634; GO:0005730; GO:0006260; GO:0006265; GO:0006338; GO:0007059; GO:0031298; GO:0031616 0 0 0 PF14370;PF01028;PF02919; O73853 CHOYP_BRAFLDRAFT_121141.1.2 m.51438 sp CP17A_ICTPU 28.627 510 327 16 9 495 4 499 3.52E-56 198 CP17A_ICTPU reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" cyp17a1 cyp17 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 514 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; P02637 CHOYP_SCP.3.12 m.27952 sp SCP_MIZYE 59.659 176 69 2 2 176 2 176 3.52E-71 215 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P10394 CHOYP_LOC100535270.4.4 m.55844 sp POL4_DROME 29.659 998 580 22 163 1093 270 1212 3.52E-128 427 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P11442 CHOYP_CLH1.1.2 m.19771 sp CLH1_RAT 84.574 188 23 1 23 210 1 182 3.52E-106 337 CLH1_RAT reviewed Clathrin heavy chain 1 Cltc Rattus norvegicus (Rat) 1675 Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; mitotic nuclear division [GO:0007067]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; receptor-mediated endocytosis [GO:0006898] GO:0005198; GO:0005819; GO:0006886; GO:0006898; GO:0007030; GO:0007067; GO:0008022; GO:0030118; GO:0030130; GO:0030132; GO:0030315; GO:0030506; GO:0030669; GO:0031072; GO:0042277; GO:0042383; GO:0042470; GO:0043195; GO:1900126 0 0 0 PF00637;PF09268;PF01394; P21329 CHOYP_LOC100561123.22.28 m.43765 sp RTJK_DROFU 27.57 214 141 4 3 210 558 763 3.52E-14 79.3 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; Q00492 CHOYP_SUM1.1.1 m.44002 sp SUM1_LYTVA 60.556 180 51 6 166 341 77 240 3.52E-60 197 SUM1_LYTVA reviewed Transcription factor SUM-1 (Sea urchin myogenic factor 1) SUM-1 Lytechinus variegatus (Green sea urchin) (Variegated urchin) 260 "muscle organ development [GO:0007517]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007517 0 0 0 PF01586;PF00010;PF12232; Q56P03 CHOYP_EAPP.1.1 m.24253 sp EAPP_HUMAN 43.051 295 144 9 5 286 1 284 3.52E-57 188 EAPP_HUMAN reviewed E2F-associated phosphoprotein (EAPP) EAPP C14orf11 BM-036 Homo sapiens (Human) 285 negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968] GO:0005634; GO:0005737; GO:0005794; GO:0008284; GO:0032968; GO:0034244 0 0 0 PF10238; Q58588 CHOYP_BRAFLDRAFT_127093.3.3 m.46561 sp Y1187_METJA 24.479 192 131 6 52 242 123 301 3.52E-07 53.5 Y1187_METJA reviewed Uncharacterized protein MJ1187 (EC 3.2.2.-) MJ1187 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 301 0 GO:0016787 0 0 0 PF03747; Q5G267 CHOYP_TRIADDRAFT_53242.2.3 m.38278 sp NETR_MACMU 45 160 86 1 2 161 333 490 3.52E-41 151 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5T089 CHOYP_BRAFLDRAFT_124536.2.2 m.56603 sp MORN1_HUMAN 32.51 526 269 12 86 589 25 486 3.52E-83 272 MORN1_HUMAN reviewed MORN repeat-containing protein 1 MORN1 Homo sapiens (Human) 497 0 0 0 0 0 PF02493; Q5UPJ3 CHOYP_LOC580909.1.2 m.31932 sp YL116_MIMIV 43.182 176 89 4 958 1131 132 298 3.52E-13 77.4 YL116_MIMIV reviewed Uncharacterized protein L116 MIMI_L116 Acanthamoeba polyphaga mimivirus (APMV) 563 0 0 0 0 0 0 Q61549 CHOYP_GP126.1.1 m.4716 sp AGRE1_MOUSE 26.136 352 186 12 679 1024 643 926 3.52E-19 97.4 AGRE1_MOUSE reviewed Adhesion G protein-coupled receptor E1 (Cell surface glycoprotein F4/80) (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor) Adgre1 Emr1 Gpf480 Mus musculus (Mouse) 931 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] GO:0002250; GO:0004930; GO:0005509; GO:0005886; GO:0007166; GO:0009897; GO:0016021; GO:0071944 0 0 0 PF00002;PF12662;PF07645;PF01825; Q65YR7 CHOYP_LOC100899149.1.2 m.6146 sp CYTA2_DICDI 38.384 99 54 2 37 135 4 95 3.52E-13 63.9 CYTA2_DICDI reviewed Cystatin-A2 cpiB DDB_G0280439 Dictyostelium discoideum (Slime mold) 95 proteolysis [GO:0006508] GO:0004869; GO:0005829; GO:0006508 0 0 0 PF00031; Q6DIB5 CHOYP_LOC101158923.1.2 m.27410 sp MEG10_MOUSE 35.326 368 173 16 51 369 349 700 3.52E-43 165 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q7Q968 CHOYP_NTAQ1.1.1 m.49673 sp NTAQ1_ANOGA 49.451 182 91 1 7 187 16 197 3.52E-64 199 NTAQ1_ANOGA reviewed Protein N-terminal glutamine amidohydrolase (EC 3.5.1.-) (Protein NH2-terminal glutamine deamidase) (N-terminal Gln amidase) (Nt(Q)-amidase) (Protein tungus) tun AGAP004865 Anopheles gambiae (African malaria mosquito) 211 0 GO:0016811 0 0 0 PF09764; Q7ZWE3 CHOYP_LARP7.1.1 m.35019 sp LARP7_DANRE 46.231 199 99 4 1 197 18 210 3.52E-50 186 LARP7_DANRE reviewed La-related protein 7 (La ribonucleoprotein domain family member 7) larp7 zgc:56476 Danio rerio (Zebrafish) (Brachydanio rerio) 555 RNA processing [GO:0006396] GO:0000166; GO:0003723; GO:0005634; GO:0006396; GO:0030529 0 0 0 PF05383;PF00076;PF08777; Q8BGG9 CHOYP_LOC101029963.1.1 m.16662 sp ACNT2_MOUSE 38.509 161 91 5 33 191 3 157 3.52E-26 107 ACNT2_MOUSE reviewed Acyl-coenzyme A amino acid N-acyltransferase 2 (EC 2.3.1.-) Acnat2 Mus musculus (Mouse) 420 acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] GO:0005777; GO:0006631; GO:0006637; GO:0016410; GO:0016790 0 0 0 PF08840;PF04775; Q8CF89 CHOYP_BRAFLDRAFT_259980.1.1 m.17608 sp TAB1_MOUSE 46.107 488 242 8 75 558 16 486 3.52E-132 399 TAB1_MOUSE reviewed TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) Tab1 Map3k7ip1 Mus musculus (Mouse) 502 activation of MAPKKK activity [GO:0000185]; aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0000185; GO:0001701; GO:0003007; GO:0003279; GO:0004722; GO:0005654; GO:0005737; GO:0007179; GO:0019209; GO:0030324; GO:0035904; GO:0060976 0 0 0 PF00481; Q90X38 CHOYP_LOC575416.1.1 m.19797 sp GPKOW_DANRE 39.319 529 255 12 15 531 28 502 3.52E-113 348 GPKOW_DANRE reviewed G patch domain and KOW motifs-containing protein (Protein T54-like) gpkow t54l si:dz150f13.5 zgc:152714 Danio rerio (Zebrafish) (Brachydanio rerio) 506 0 GO:0003676; GO:0005634 0 0 0 PF12656;PF00467; Q96MK2 CHOYP_FA65A.1.1 m.24019 sp FA65C_HUMAN 25.163 922 550 26 155 1002 69 924 3.52E-73 264 FA65C_HUMAN reviewed Protein FAM65C FAM65C C20orf175 Homo sapiens (Human) 946 0 GO:0005737 0 0 0 PF15903; Q9NR33 CHOYP_BRAFLDRAFT_284508.1.1 m.4587 sp DPOE4_HUMAN 43.396 106 60 0 10 115 12 117 3.52E-28 102 DPOE4_HUMAN reviewed DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) POLE4 Homo sapiens (Human) 117 histone H3 acetylation [GO:0043966] GO:0003677; GO:0003887; GO:0005634; GO:0005671; GO:0008622; GO:0043966 0 0 0 PF00808; Q9U943 CHOYP_APLP.1.2 m.5955 sp APLP_LOCMI 30.035 1142 708 26 5 1089 9 1116 3.52E-130 467 APLP_LOCMI reviewed Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] 0 Locusta migratoria (Migratory locust) 3380 Wnt signaling pathway [GO:0016055] GO:0005319; GO:0005576; GO:0008289; GO:0016055 0 0 0 PF08742;PF06448;PF09172;PF01347;PF00094; B3EWZ3 CHOYP_BRAFLDRAFT_68242.3.3 m.45662 sp CADN_ACRMI 43.114 334 167 7 31 346 227 555 3.53E-70 244 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; E1BWM5 CHOYP_BRAFLDRAFT_117725.1.3 m.27814 sp FUND1_CHICK 42.143 140 73 3 6 138 17 155 3.53E-30 109 FUND1_CHICK reviewed FUN14 domain-containing protein 1 FUNDC1 Gallus gallus (Chicken) 156 mitophagy [GO:0000422]; response to hypoxia [GO:0001666] GO:0000422; GO:0001666; GO:0031307 0 0 0 PF04930; E1BWM5 CHOYP_BRAFLDRAFT_117725.3.3 m.61023 sp FUND1_CHICK 42.143 140 73 3 6 138 17 155 3.53E-30 109 FUND1_CHICK reviewed FUN14 domain-containing protein 1 FUNDC1 Gallus gallus (Chicken) 156 mitophagy [GO:0000422]; response to hypoxia [GO:0001666] GO:0000422; GO:0001666; GO:0031307 0 0 0 PF04930; G5ED84 CHOYP_LOC100575377.4.10 m.25901 sp KLHL8_CAEEL 26.875 160 105 4 10 158 88 246 3.53E-09 63.5 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O75382 CHOYP_BRAFLDRAFT_69765.12.23 m.46772 sp TRIM3_HUMAN 23.636 220 153 7 177 390 534 744 3.53E-07 55.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P23381 CHOYP_WARS.1.1 m.25086 sp SYWC_HUMAN 77.193 114 26 0 21 134 81 194 3.53E-60 195 SYWC_HUMAN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS IFI53 WRS Homo sapiens (Human) 471 angiogenesis [GO:0001525]; negative regulation of cell proliferation [GO:0008285]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0001525; GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006412; GO:0006418; GO:0006436; GO:0008285; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P70451 CHOYP_FPS.1.2 m.53744 sp FER_MOUSE 37.736 371 209 10 259 614 448 811 3.53E-69 243 FER_MOUSE reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) (Proto-oncogene c-Fer) (p94-Fer) Fer Fert2 Mus musculus (Mouse) 823 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell proliferation [GO:0008283]; cellular response to insulin stimulus [GO:0032869]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; epidermal growth factor receptor signaling pathway [GO:0007173]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; interleukin-6-mediated signaling pathway [GO:0070102]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]; tyrosine phosphorylation of Stat3 protein [GO:0042503] GO:0000226; GO:0000278; GO:0000790; GO:0001932; GO:0004672; GO:0004715; GO:0005102; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005938; GO:0006468; GO:0006935; GO:0007155; GO:0007165; GO:0007173; GO:0008157; GO:0008283; GO:0008284; GO:0008289; GO:0010591; GO:0010762; GO:0015629; GO:0015630; GO:0018108; GO:0019221; GO:0030027; GO:0030054; GO:0030335; GO:0030838; GO:0031234; GO:0031532; GO:0032496; GO:0032869; GO:0033007; GO:0034446; GO:0034614; GO:0035426; GO:0036006; GO:0036119; GO:0038028; GO:0038083; GO:0038095; GO:0038109; GO:0042058; GO:0042127; GO:0042503; GO:0043304; GO:0044331; GO:0045087; GO:0046777; GO:0048008; GO:0050904; GO:0051092; GO:0070102 0 0 0 PF00611;PF07714;PF00017; Q02293 CHOYP_LOC586698.1.1 m.40570 sp FNTB_RAT 45.37 108 54 1 16 123 32 134 3.53E-23 97.4 FNTB_RAT reviewed Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) Fntb Rattus norvegicus (Rat) 437 negative regulation of cell proliferation [GO:0008285]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; protein farnesylation [GO:0018343]; response to cytokine [GO:0034097]; response to inorganic substance [GO:0010035]; response to organic cyclic compound [GO:0014070]; wound healing [GO:0042060] GO:0004311; GO:0004660; GO:0005875; GO:0005965; GO:0008270; GO:0008284; GO:0008285; GO:0010035; GO:0014070; GO:0018343; GO:0034097; GO:0042060; GO:0043234; GO:0045787; GO:0048146; GO:0051770 0 0 cd02893; PF00432; Q05695 CHOYP_CRE_29942.1.1 m.48587 sp L1CAM_RAT 24.524 420 280 14 40 444 48 445 3.53E-25 113 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q05722 CHOYP_CO4A2.2.2 m.51283 sp CO9A1_MOUSE 48.305 118 33 6 2 106 490 592 3.53E-10 58.9 CO9A1_MOUSE reviewed Collagen alpha-1(IX) chain Col9a1 Mus musculus (Mouse) 921 cartilage development [GO:0051216]; growth plate cartilage development [GO:0003417]; tissue homeostasis [GO:0001894] GO:0001894; GO:0003417; GO:0005578; GO:0005594; GO:0046872; GO:0051216 0 0 0 PF01391; Q0VD31 CHOYP_FBXL4.1.1 m.61579 sp FBXL4_BOVIN 26.809 235 136 8 22 222 48 280 3.53E-16 82 FBXL4_BOVIN reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) FBXL4 Bos taurus (Bovine) 621 0 GO:0005634; GO:0005758 0 0 0 PF00646; Q1MTN8 CHOYP_LOC100891594.1.2 m.27215 sp ACL4_SCHPO 31.615 291 151 8 91 359 40 304 3.53E-34 132 ACL4_SCHPO reviewed Probable assembly chaperone of rpl4 SPBC16D10.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 336 ribosome biogenesis [GO:0042254] GO:0005634; GO:0005730; GO:0005737; GO:0042254; GO:0043234 0 0 0 PF13181; Q24307 CHOYP_TIAP2.1.13 m.15429 sp DIAP2_DROME 43.243 74 42 0 148 221 425 498 3.53E-16 80.1 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q4PM12 CHOYP_RL36.5.8 m.30114 sp RL36_IXOSC 60.465 86 32 1 18 103 1 84 3.53E-32 112 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q4V7Y7 CHOYP_KTNB1.1.1 m.2199 sp KTNB1_XENLA 46.853 286 122 6 1 279 159 421 3.53E-80 259 KTNB1_XENLA reviewed Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin) katnb1 Xenopus laevis (African clawed frog) 655 cell division [GO:0051301]; microtubule severing [GO:0051013]; mitotic nuclear division [GO:0007067] GO:0000922; GO:0005813; GO:0005874; GO:0007067; GO:0008352; GO:0051013; GO:0051301 0 0 0 PF13925;PF00400; Q55GU0 CHOYP_BRAFLDRAFT_119173.4.4 m.35619 sp Y9955_DICDI 39.194 273 151 6 113 382 655 915 3.53E-48 185 Y9955_DICDI reviewed Probable serine/threonine-protein kinase DDB_G0267514 (EC 2.7.11.1) DDB_G0267514 Dictyostelium discoideum (Slime mold) 916 0 GO:0004674; GO:0005524 0 0 0 PF07714; Q567B1 CHOYP_OTU1.1.1 m.49204 sp OTU1_DANRE 51.485 303 144 1 6 308 2 301 3.53E-109 322 OTU1_DANRE reviewed Ubiquitin thioesterase OTU1 (EC 3.4.19.12) yod1 zgc:112182 Danio rerio (Zebrafish) (Brachydanio rerio) 301 endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; protein K11-linked deubiquitination [GO:0035871]; protein K27-linked deubiquitination [GO:1990167]; protein K29-linked deubiquitination [GO:0035523]; protein K33-linked deubiquitination [GO:1990168]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536] GO:0004843; GO:0030433; GO:0030968; GO:0035523; GO:0035871; GO:0046872; GO:0070536; GO:0071108; GO:1990167; GO:1990168 0 0 0 PF02338;PF14560; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.1.34 m.2693 sp VWDE_HUMAN 25.561 223 153 6 214 431 747 961 3.53E-09 63.9 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N6D5 CHOYP_TVAG_033450.2.4 m.39663 sp ANR29_HUMAN 39.416 137 83 0 1 137 65 201 3.53E-26 102 ANR29_HUMAN reviewed Ankyrin repeat domain-containing protein 29 ANKRD29 Homo sapiens (Human) 301 0 0 0 0 0 PF00023;PF12796; Q8WPI2 CHOYP_LOC100905729.1.3 m.13789 sp BOOH2_RHIMP 40.845 71 42 0 11 81 1 71 3.53E-14 67.4 BOOH2_RHIMP reviewed Boophilin-H2 H2 Rhipicephalus microplus (Cattle tick) (Boophilus microplus) 142 0 GO:0004867; GO:0005576 0 0 0 PF00014; Q91ZU9 CHOYP_LOC100373663.1.1 m.29316 sp NMD3B_MOUSE 24.643 280 190 10 263 531 313 582 3.53E-14 79.3 NMD3B_MOUSE reviewed "Glutamate receptor ionotropic, NMDA 3B (GluN3B) (N-methyl-D-aspartate receptor subunit NR3B) (NMDAR3B) (NR3B) (NMDA receptor 4) (Nr4)" Grin3b Mus musculus (Mouse) 1003 calcium ion transmembrane transport [GO:0070588]; protein insertion into membrane [GO:0051205]; regulation of calcium ion transport [GO:0051924] GO:0004972; GO:0005234; GO:0017146; GO:0030054; GO:0043025; GO:0045211; GO:0051205; GO:0051924; GO:0070588 0 0 0 PF00060;PF10613; Q99M80 CHOYP_LOC101071230.1.1 m.22193 sp PTPRT_MOUSE 30.925 692 430 17 444 1095 768 1451 3.53E-82 297 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99MQ3 CHOYP_RS6.3.12 m.5754 sp PINK1_MOUSE 35.749 414 221 8 117 521 128 505 3.53E-75 254 PINK1_MOUSE reviewed "Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)" Pink1 Mus musculus (Mouse) 580 "cellular response to hypoxia [GO:0071456]; cellular response to oxidative stress [GO:0034599]; cellular response to toxic substance [GO:0097237]; establishment of protein localization to mitochondrion [GO:0072655]; intracellular signal transduction [GO:0035556]; maintenance of protein location in mitochondrion [GO:0072656]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000422]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [GO:1903384]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:1903751]; negative regulation of macroautophagy [GO:0016242]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitophagy [GO:1903147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of oxidative stress-induced cell death [GO:1903202]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of cristae formation [GO:1903852]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of histone deacetylase activity [GO:1901727]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial electron transport, NADH to ubiquinone [GO:1902958]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mitochondrion organization [GO:0010821]; regulation of neuron apoptotic process [GO:0043523]; regulation of oxidative phosphorylation [GO:0002082]; regulation of protein complex assembly [GO:0043254]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of protein ubiquitination [GO:0031396]; regulation of reactive oxygen species metabolic process [GO:2000377]; respiratory electron transport chain [GO:0022904]; response to oxidative stress [GO:0006979]; response to stress [GO:0006950]" GO:0000287; GO:0000422; GO:0000785; GO:0001934; GO:0002020; GO:0002082; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005742; GO:0005743; GO:0005758; GO:0005829; GO:0005856; GO:0006468; GO:0006950; GO:0006979; GO:0007005; GO:0010310; GO:0010629; GO:0010821; GO:0010857; GO:0016020; GO:0016239; GO:0016242; GO:0016301; GO:0016567; GO:0018105; GO:0022904; GO:0030424; GO:0031307; GO:0031396; GO:0031625; GO:0031932; GO:0032226; GO:0033138; GO:0033603; GO:0033605; GO:0034599; GO:0035307; GO:0035556; GO:0036289; GO:0043123; GO:0043254; GO:0043422; GO:0043523; GO:0043524; GO:0044297; GO:0045727; GO:0048471; GO:0050821; GO:0051091; GO:0051881; GO:0055131; GO:0071456; GO:0072655; GO:0072656; GO:0090141; GO:0090200; GO:0090258; GO:0097237; GO:0097449; GO:0098779; GO:1901727; GO:1902902; GO:1902958; GO:1903147; GO:1903202; GO:1903214; GO:1903298; GO:1903384; GO:1903751; GO:1903852; GO:1903955; GO:2000377; GO:2000378 0 0 0 PF00069; Q9D4H1 CHOYP_BRAFLDRAFT_214268.1.1 m.38116 sp EXOC2_MOUSE 32.075 106 55 2 204 294 8 111 3.53E-08 59.7 EXOC2_MOUSE reviewed Exocyst complex component 2 (Exocyst complex component Sec5) Exoc2 Sec5 Sec5l1 Mus musculus (Mouse) 924 exocyst assembly [GO:0001927]; Golgi to plasma membrane transport [GO:0006893]; membrane organization [GO:0061024]; positive regulation of exocytosis [GO:0045921]; protein transport [GO:0015031]; regulation of entry of bacterium into host cell [GO:2000535] GO:0000145; GO:0001927; GO:0005886; GO:0006893; GO:0015031; GO:0016020; GO:0017160; GO:0019901; GO:0043231; GO:0045921; GO:0047485; GO:0061024; GO:2000535 0 0 0 PF01833; Q9JIP0 CHOYP_BRAFLDRAFT_125475.1.2 m.23077 sp TRPV5_RAT 32.796 186 101 5 26 210 374 536 3.53E-18 86.7 TRPV5_RAT reviewed Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transporter 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) Trpv5 Cat2 Ecac Ecac1 Rattus norvegicus (Rat) 723 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein tetramerization [GO:0051262] GO:0005262; GO:0005887; GO:0006816; GO:0016324; GO:0051262; GO:0060402 0 0 0 PF12796;PF00520; Q9QYI5 CHOYP_DNAJB6B.2.2 m.61976 sp DNJB2_MOUSE 52.535 217 87 6 5 218 4 207 3.53E-58 188 DNJB2_MOUSE reviewed DnaJ homolog subfamily B member 2 (DnaJ homolog subfamily B member 10) (mDj8) Dnajb2 Dnajb10 Mus musculus (Mouse) 277 negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of inclusion body assembly [GO:0090084]; protein refolding [GO:0042026] GO:0005634; GO:0005829; GO:0008285; GO:0030308; GO:0042026; GO:0051082; GO:0051087; GO:0090084 0 0 cd06257; PF00226;PF02809; Q9R1R2 CHOYP_contig_040697 m.46256 sp TRIM3_MOUSE 26.016 123 86 3 77 195 622 743 3.53E-06 51.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9ULJ7 CHOYP_LOC755521.26.28 m.57330 sp ANR50_HUMAN 34.959 369 233 2 358 721 523 889 3.53E-55 209 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9Y2C9 CHOYP_TLR2.3.7 m.42981 sp TLR6_HUMAN 30.818 318 190 9 279 590 448 741 3.53E-31 132 TLR6_HUMAN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) 796 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0038124; GO:0042088; GO:0042496; GO:0042742; GO:0043123; GO:0043507; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; A6BM72 CHOYP_MEG11.4.25 m.23000 sp MEG11_HUMAN 39.184 245 129 12 122 363 305 532 3.54E-32 131 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; B8JK39 CHOYP_ITA9.1.2 m.40672 sp ITA9_MOUSE 23.262 1079 667 44 30 1033 42 1034 3.54E-49 194 ITA9_MOUSE reviewed Integrin alpha-9 Itga9 Mus musculus (Mouse) 1036 cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]; neutrophil chemotaxis [GO:0030593]; wound healing [GO:0042060] GO:0007155; GO:0007229; GO:0009925; GO:0030593; GO:0034679; GO:0042060; GO:0046872 0 0 0 PF01839;PF08441; O97159 CHOYP_CHD5.1.2 m.18515 sp CHDM_DROME 67.227 119 36 1 1 119 1846 1961 3.54E-40 145 CHDM_DROME reviewed Chromodomain-helicase-DNA-binding protein Mi-2 homolog (EC 3.6.4.12) (ATP-dependent helicase Mi-2) (dMi-2) Mi-2 CG8103 Drosophila melanogaster (Fruit fly) 1982 "ATP-dependent chromatin remodeling [GO:0043044]; chromosome decondensation [GO:0051312]; chromosome organization [GO:0051276]; dendrite morphogenesis [GO:0048813]; muscle organ development [GO:0007517]; negative regulation of cohesin loading [GO:0071923]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome mobilization [GO:0042766]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003682; GO:0004003; GO:0004386; GO:0005524; GO:0005634; GO:0005700; GO:0005829; GO:0006351; GO:0006357; GO:0007283; GO:0007517; GO:0008270; GO:0016581; GO:0016887; GO:0031491; GO:0035327; GO:0042766; GO:0043044; GO:0045892; GO:0048813; GO:0051276; GO:0051312; GO:0070615; GO:0071923 0 0 0 PF08074;PF08073;PF00385;PF06461;PF06465;PF00271;PF00628;PF00176; P12812 CHOYP_SMP_148530.1.1 m.18051 sp P40_SCHMA 27.742 310 172 14 39 315 64 354 3.54E-25 107 P40_SCHMA reviewed Major egg antigen (p40) 0 Schistosoma mansoni (Blood fluke) 354 0 0 0 0 0 PF00011; P29691 CHOYP_LOC101242512.1.1 m.48604 sp EF2_CAEEL 58.065 186 66 2 1 174 169 354 3.54E-65 217 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P48065 CHOYP_LOC100694392.1.1 m.43738 sp S6A12_HUMAN 52.48 383 182 0 2 384 199 581 3.54E-141 418 S6A12_HUMAN reviewed Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12) SLC6A12 Homo sapiens (Human) 614 amino acid transport [GO:0006865]; cellular hyperosmotic response [GO:0071474]; cellular water homeostasis [GO:0009992]; chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid transport [GO:0015812]; neurotransmitter transport [GO:0006836]; response to organic substance [GO:0010033]; transport [GO:0006810] GO:0005328; GO:0005332; GO:0005886; GO:0005887; GO:0006810; GO:0006836; GO:0006865; GO:0007268; GO:0009992; GO:0010033; GO:0015171; GO:0015812; GO:0016021; GO:0043005; GO:0071474 0 0 0 PF00209; P49908 CHOYP_SEPP1.1.3 m.5949 sp SEPP1_HUMAN 35.789 95 56 3 1 90 61 155 3.54E-10 60.8 SEPP1_HUMAN reviewed Selenoprotein P (SeP) SEPP1 SELP Homo sapiens (Human) 381 brain development [GO:0007420]; growth [GO:0040007]; locomotory behavior [GO:0007626]; platelet degranulation [GO:0002576]; post-embryonic development [GO:0009791]; response to oxidative stress [GO:0006979]; selenium compound metabolic process [GO:0001887]; sexual reproduction [GO:0019953] GO:0001887; GO:0002576; GO:0005576; GO:0005615; GO:0006979; GO:0007420; GO:0007626; GO:0008430; GO:0009791; GO:0019953; GO:0031089; GO:0040007; GO:0070062 0 0 0 PF04593;PF04592; P54864 CHOYP_LOC101077059.1.1 m.57292 sp JUN_SERCA 45.714 315 135 11 4 289 5 312 3.54E-73 230 JUN_SERCA reviewed Transcription factor AP-1 (Proto-oncogene c-Jun) JUN Serinus canaria (Island canary) (Fringilla canaria) 314 "Ras protein signal transduction [GO:0007265]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007265; GO:0043565; GO:0044212 0 0 0 PF00170;PF03957; P82596 CHOYP_LOC100563402.1.1 m.5257 sp PLC_HALLA 39.695 131 75 4 19 147 2 130 3.54E-22 89.7 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q06852 CHOYP_contig_043845 m.50665 sp SLAP1_CLOTH 60.909 110 28 9 350 445 1546 1654 3.54E-07 57.4 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0VC80 CHOYP_LOC588740.1.1 m.44545 sp YRDC_BOVIN 46.341 82 44 0 35 116 71 152 3.54E-18 80.9 YRDC_BOVIN reviewed "YrdC domain-containing protein, mitochondrial" YRDC Bos taurus (Bovine) 276 negative regulation of transport [GO:0051051]; regulation of translational fidelity [GO:0006450]; tRNA threonylcarbamoyladenosine modification [GO:0002949] GO:0000049; GO:0002949; GO:0003725; GO:0005737; GO:0005739; GO:0006450; GO:0016020; GO:0016779; GO:0051051 0 0 0 PF01300; Q20930 CHOYP_LOAG_00377.3.4 m.57400 sp MIG17_CAEEL 34.074 270 149 16 267 514 198 460 3.54E-29 126 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q3U3Q1 CHOYP_BRAFLDRAFT_110776.1.1 m.22666 sp ULK3_MOUSE 51.528 458 215 3 25 481 8 459 3.54E-165 478 ULK3_MOUSE reviewed Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3) Ulk3 Mus musculus (Mouse) 472 autophagy [GO:0006914]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autophosphorylation [GO:0046777] GO:0004674; GO:0005524; GO:0005737; GO:0006914; GO:0045879; GO:0045880; GO:0046777 0 0 0 PF04212;PF00069; Q62158 CHOYP_LOC100374741.48.83 m.42419 sp TRI27_MOUSE 28.846 208 124 6 45 237 96 294 3.54E-07 55.1 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q642A0 CHOYP_PDRG1.3.3 m.62720 sp PDRG1_RAT 45.669 127 68 1 6 131 5 131 3.54E-33 115 PDRG1_RAT reviewed p53 and DNA damage-regulated protein 1 Pdrg1 Rattus norvegicus (Rat) 133 protein folding [GO:0006457] GO:0005737; GO:0006457; GO:0016272 0 0 0 PF01920; Q64459 CHOYP_CP3AB.2.4 m.7473 sp CP3AB_MOUSE 33.659 511 315 11 2 508 7 497 3.54E-84 272 CP3AB_MOUSE reviewed Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (Cytochrome P-450IIIAM1) (Cytochrome P-450UT) Cyp3a11 Cyp3a-11 Mus musculus (Mouse) 504 0 GO:0004497; GO:0005506; GO:0005789; GO:0016491; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q6DDL7 CHOYP_UN93A.2.3 m.44335 sp UN93A_XENLA 48.214 448 223 5 29 472 2 444 3.54E-146 429 UN93A_XENLA reviewed Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) 460 0 GO:0016021 0 0 cd06174; PF05978; Q76P29 CHOYP_TRIADDRAFT_58364.1.1 m.25992 sp IMAB_DICDI 30.882 204 124 5 3 194 9 207 3.54E-18 85.5 IMAB_DICDI reviewed Importin subunit alpha-B (Karyopherin subunit alpha-B) DDB_G0272318 Dictyostelium discoideum (Slime mold) 516 NLS-bearing protein import into nucleus [GO:0006607] GO:0005643; GO:0005654; GO:0005829; GO:0006607; GO:0008139; GO:0008565 0 0 0 PF00514;PF16186;PF01749; Q7LL04 CHOYP_BRAFLDRAFT_119712.1.1 m.49642 sp YQK1_SCHPO 30.682 264 168 7 28 283 18 274 3.54E-34 130 YQK1_SCHPO reviewed UPF0676 protein C1494.01 SPCC1494.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 321 0 GO:0005634; GO:0005737; GO:0005829; GO:0051213 0 0 0 PF03171;PF14226; Q7Z5L3 CHOYP_C1QL2.17.32 m.27951 sp C1QL2_HUMAN 31.783 129 83 3 300 426 160 285 3.54E-08 58.2 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q80T91 CHOYP_LOC100369496.1.1 m.40060 sp MEG11_MOUSE 32.8 125 62 5 638 751 567 680 3.54E-09 67.4 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q80ZD3 CHOYP_S2611.1.1 m.14613 sp S2611_MOUSE 49.033 569 281 4 68 636 7 566 3.54E-176 517 S2611_MOUSE reviewed Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11) Slc26a11 Mus musculus (Mouse) 593 bicarbonate transport [GO:0015701]; chloride transmembrane transport [GO:1902476]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sulfate transport [GO:0008272] GO:0005254; GO:0005654; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0008271; GO:0008272; GO:0008509; GO:0015106; GO:0015116; GO:0015301; GO:0015701; GO:0016021; GO:0019531; GO:0042391; GO:0043231; GO:0051453; GO:0070062; GO:1902476 0 0 0 PF01740;PF00916; Q86Y13 CHOYP_LOC100175215.1.1 m.13446 sp DZIP3_HUMAN 32.787 183 92 7 1529 1684 1020 1198 3.54E-12 75.5 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8CHQ0 CHOYP_NEMVEDRAFT_V1G210610.2.2 m.56424 sp FBX4_MOUSE 29.755 326 215 5 79 390 57 382 3.54E-48 171 FBX4_MOUSE reviewed F-box only protein 4 Fbxo4 Fbx4 Mus musculus (Mouse) 385 aging [GO:0007568]; cellular homeostasis [GO:0019725]; cellular response to ionizing radiation [GO:0071479]; common myeloid progenitor cell proliferation [GO:0035726]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; posttranscriptional regulation of gene expression [GO:0010608]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000209; GO:0000723; GO:0004842; GO:0005737; GO:0006511; GO:0007568; GO:0010608; GO:0016567; GO:0019005; GO:0019725; GO:0031146; GO:0031398; GO:0031648; GO:0035726; GO:0042803; GO:0048147; GO:0061630; GO:0071479; GO:1900181; GO:1902916; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; Q8JG70 CHOYP_LOC100890718.1.1 m.25132 sp AA2DA_DANRE 22.851 442 289 12 1 430 1 402 3.54E-12 71.2 AA2DA_DANRE reviewed Alpha-2Da adrenergic receptor (Alpha-2Da adrenoceptor) (Alpha(2Da)AR) (Alpha-2Da adrenoreceptor) adra2da Danio rerio (Zebrafish) (Brachydanio rerio) 408 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; cell-cell signaling [GO:0007267]; negative regulation of adenylate cyclase activity [GO:0007194] GO:0004938; GO:0005887; GO:0007194; GO:0007267; GO:0071880 0 0 0 PF00001; Q8NEG5 CHOYP_LOC100371610.1.2 m.11387 sp ZSWM2_HUMAN 42.198 455 224 11 8 453 12 436 3.54E-117 368 ZSWM2_HUMAN reviewed E3 ubiquitin-protein ligase ZSWIM2 (EC 6.3.2.-) (MEKK1-related protein X) (MEX) (ZZ-type zinc finger-containing protein 2) (Zinc finger SWIM domain-containing protein 2) ZSWIM2 ZZZ2 Homo sapiens (Human) 633 apoptotic process [GO:0006915]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0006915; GO:0008270; GO:0016874; GO:0061630; GO:1902043 0 0 0 PF04434;PF13639;PF00569; Q8VCC1 CHOYP_HPGD.1.3 m.50258 sp PGDH_MOUSE 40.304 263 150 3 1 258 1 261 3.54E-60 194 PGDH_MOUSE reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) Hpgd Pgdh1 Mus musculus (Mouse) 269 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005654; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070062; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q8VIP2 CHOYP_LOC101078430.1.1 m.45131 sp MLXPL_RAT 63.776 196 71 0 715 910 661 856 3.54E-74 264 MLXPL_RAT reviewed Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) Mlxipl Wbscr14 Rattus norvegicus (Rat) 865 "cellular response to glucose stimulus [GO:0071333]; energy reserve metabolic process [GO:0006112]; fatty acid homeostasis [GO:0055089]; regulation of energy homeostasis [GO:2000505]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of glycolytic process [GO:0006110]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to glucose [GO:0009749]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006110; GO:0006112; GO:0006351; GO:0006357; GO:0009749; GO:0019901; GO:0035538; GO:0042304; GO:0043565; GO:0055089; GO:0071333; GO:2000505 0 0 0 PF00010; Q9D2Q2 CHOYP_LOC100560985.1.1 m.40821 sp TRM44_MOUSE 43.023 86 49 0 2 87 416 501 3.54E-16 82 TRM44_MOUSE reviewed Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19) Trmt44 Mettl19 Mus musculus (Mouse) 713 tRNA methylation [GO:0030488] GO:0005737; GO:0016300; GO:0030488; GO:0046872 0 0 0 PF07757; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.14.15 m.61024 sp SACS_MOUSE 30.648 1080 624 40 23 1024 1275 2307 3.54E-113 390 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9UKJ5 CHOYP_LOC100366987.2.2 m.61973 sp CHIC2_HUMAN 69.065 139 43 0 42 180 27 165 3.54E-62 192 CHIC2_HUMAN reviewed Cysteine-rich hydrophobic domain-containing protein 2 (BrX-like translocated in leukemia) CHIC2 BTL Homo sapiens (Human) 165 Golgi to plasma membrane transport [GO:0006893] GO:0005798; GO:0005886; GO:0006893 0 0 0 PF10256; Q9VCA2 CHOYP_DVIR_GJ24209.1.1 m.3362 sp ORCT_DROME 43.228 539 261 9 1 520 10 522 3.54E-133 401 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; P11240 CHOYP_TRIADDRAFT_26618.1.3 m.21880 sp COX5A_RAT 39.344 122 68 2 21 142 22 137 3.55E-22 89 COX5A_RAT reviewed "Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)" Cox5a Rattus norvegicus (Rat) 146 "mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" GO:0004129; GO:0005751; GO:0006123; GO:0043209; GO:0046872; GO:0070062 0 0 cd00923; PF02284; P16157 CHOYP_TVAG_123950.15.31 m.36636 sp ANK1_HUMAN 29.258 458 298 7 451 889 139 589 3.55E-48 190 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P24081 CHOYP_LOC100574426.2.2 m.51473 sp AN_NPVOP 25 236 130 12 16 229 36 246 3.55E-07 53.9 AN_NPVOP reviewed Alkaline nuclease (AN) (EC 3.1.-.-) ALK-EXO ORF131 Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) 424 0 GO:0003677; GO:0004519; GO:0004527; GO:0042025 0 0 0 PF01771; Q5VU97 CHOYP_LOC100374527.1.1 m.55215 sp CAHD1_HUMAN 26.252 1078 692 41 18 1023 17 1063 3.55E-83 299 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q5XI56 CHOYP_LOC100378540.1.3 m.5654 sp ERIP6_RAT 31.724 145 71 5 232 371 177 298 3.55E-10 65.5 ERIP6_RAT reviewed Glutamate-rich protein 6 (Protein FAM194A) Erich6 Fam194a Rattus norvegicus (Rat) 602 0 0 0 0 0 PF14977; Q6P8Y1 CHOYP_LOC100179300.2.2 m.40974 sp CAPSL_MOUSE 50.718 209 102 1 3 211 1 208 3.55E-79 238 CAPSL_MOUSE reviewed Calcyphosin-like protein Capsl Mus musculus (Mouse) 208 0 GO:0005509; GO:0005737 0 0 0 PF13499; Q7K237 CHOYP_C1GLT.1.2 m.9167 sp C1GLT_DROME 47.748 333 165 5 8 331 18 350 3.55E-104 314 C1GLT_DROME reviewed "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC 2.4.1.122) (Core 1 O-glycan T-synthase) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1) (Core 1 beta1,3-galactosyltransferase 1) (C1GalT1) (Core 1 beta3-Gal-T1)" C1GalTA CG9520 Drosophila melanogaster (Fruit fly) 388 "central nervous system morphogenesis [GO:0021551]; glycolipid biosynthetic process [GO:0009247]; negative regulation of hematopoietic stem cell differentiation [GO:1902037]; O-glycan processing, core 1 [GO:0016267]; protein glycosylation [GO:0006486]; regulation of filopodium assembly [GO:0051489]" GO:0006486; GO:0009247; GO:0016021; GO:0016263; GO:0016267; GO:0021551; GO:0046872; GO:0048531; GO:0051489; GO:1902037 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02434; Q7TP48 CHOYP_ZGC_194209.1.1 m.9020 sp APMAP_RAT 38.903 383 217 9 34 410 5 376 3.55E-85 267 APMAP_RAT reviewed Adipocyte plasma membrane-associated protein Apmap Ab2-305 Rattus norvegicus (Rat) 376 biosynthetic process [GO:0009058] GO:0005783; GO:0009058; GO:0016020; GO:0016021; GO:0016788; GO:0016844 0 0 0 PF03088; Q8N2E2 CHOYP_LOC591161.1.2 m.29558 sp VWDE_HUMAN 41.353 266 154 2 144 407 1257 1522 3.55E-53 196 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q96IG2 CHOYP_BRAFLDRAFT_74861.1.1 m.16599 sp FXL20_HUMAN 29.557 203 128 8 83 273 141 340 3.55E-11 68.2 FXL20_HUMAN reviewed F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like) FBXL20 FBL2 Homo sapiens (Human) 436 behavioral fear response [GO:0001662] GO:0001662; GO:0005737 0 0 0 PF12937;PF13516; Q9BSE2 CHOYP_NEMVEDRAFT_V1G238109.1.3 m.4987 sp TMM79_HUMAN 28.481 158 101 4 17 167 196 348 3.55E-08 55.5 TMM79_HUMAN reviewed Transmembrane protein 79 (Mattrin) TMEM79 MATT Homo sapiens (Human) 394 cornification [GO:0070268]; cuticle development [GO:0042335]; epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; hair follicle morphogenesis [GO:0031069]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055] GO:0002070; GO:0005765; GO:0016021; GO:0031069; GO:0032588; GO:0042335; GO:0045055; GO:0045684; GO:0061436; GO:0070268 0 0 0 0 Q9D2U5 CHOYP_LOC762575.1.1 m.54012 sp LSMD1_MOUSE 52.222 90 43 0 25 114 35 124 3.55E-32 112 LSMD1_MOUSE reviewed "N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1)" Naa38 Lsmd1 Mus musculus (Mouse) 125 negative regulation of apoptotic process [GO:0043066] GO:0005634; GO:0005737; GO:0005844; GO:0031417; GO:0043066 0 0 0 PF01423; Q9D8B1 CHOYP_DMOJ_GI15038.1.1 m.17122 sp AIG1_MOUSE 42.995 207 114 1 54 256 31 237 3.55E-58 188 AIG1_MOUSE reviewed Androgen-induced gene 1 protein (AIG-1) Aig1 Mus musculus (Mouse) 262 0 GO:0016021 0 0 0 PF04750; Q9JHS4 CHOYP_CLPX.2.2 m.49273 sp CLPX_MOUSE 42.086 556 242 11 57 542 60 605 3.55E-128 392 CLPX_MOUSE reviewed "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial" Clpx Mus musculus (Mouse) 634 protein catabolic process [GO:0030163]; protein folding [GO:0006457]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004176; GO:0005524; GO:0005654; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006457; GO:0006508; GO:0009368; GO:0009841; GO:0016504; GO:0016887; GO:0030163; GO:0042645; GO:0046872; GO:0051603 0 0 0 PF07724;PF10431; Q9LDU6 CHOYP_LOC100636367.1.1 m.30562 sp ST7R_ARATH 49.057 424 207 5 56 477 16 432 3.55E-138 407 ST7R_ARATH reviewed 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Protein DWARF 5) (Sterol Delta(7)-reductase) DWF5 ST7R At1g50430 F11F12.21 Arabidopsis thaliana (Mouse-ear cress) 432 brassinosteroid biosynthetic process [GO:0016132]; cholesterol biosynthetic process [GO:0006695] GO:0005789; GO:0005794; GO:0005886; GO:0006695; GO:0009918; GO:0016021; GO:0016132; GO:0047598 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF01222; Q9UJT9 CHOYP_FBXL7.3.3 m.35857 sp FBXL7_HUMAN 24.416 385 252 8 6 388 117 464 3.55E-19 94 FBXL7_HUMAN reviewed F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7) FBXL7 FBL6 FBL7 KIAA0840 Homo sapiens (Human) 491 cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000086; GO:0000151; GO:0004842; GO:0005737; GO:0005813; GO:0006511; GO:0007067; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q9UJW2 CHOYP_LOC101067703.1.1 m.48690 sp TINAG_HUMAN 38.95 362 188 9 2 337 119 473 3.55E-81 259 TINAG_HUMAN reviewed Tubulointerstitial nephritis antigen (TIN-Ag) TINAG Homo sapiens (Human) 476 cell adhesion [GO:0007155]; immune response [GO:0006955] GO:0000166; GO:0004197; GO:0005044; GO:0005604; GO:0005615; GO:0006955; GO:0007155; GO:0030247 0 0 0 PF00112;PF01033; Q9W6V5 CHOYP_LOC763793.5.7 m.37465 sp PTPRJ_CHICK 38.308 201 122 2 343 542 1092 1291 3.55E-40 159 PTPRJ_CHICK reviewed Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Supporting-cell antigen) PTPRJ Gallus gallus (Chicken) 1406 negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of T cell receptor signaling pathway [GO:0050860]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell adhesion [GO:0045785]; positive regulation of focal adhesion assembly [GO:0051894] GO:0004725; GO:0005886; GO:0005911; GO:0016021; GO:0016791; GO:0032587; GO:0042059; GO:0043407; GO:0045785; GO:0048008; GO:0050860; GO:0051894; GO:0051898 0 0 0 PF00041;PF00102; Q9YIC0 CHOYP_EF-1A.4.9 m.37779 sp EF1A_ORYLA 89.52 229 24 0 1 229 1 229 3.55E-150 431 EF1A_ORYLA reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; A5YM72 CHOYP_CARNS1.3.6 m.15056 sp CRNS1_HUMAN 35.928 167 102 4 1 164 24 188 3.56E-22 97.1 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 B4PEU8 CHOYP_LOC101162867.1.3 m.11110 sp RS9_DROYA 77.333 150 34 0 22 171 4 153 3.56E-78 234 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; O00115 CHOYP_CRN6.1.1 m.31265 sp DNS2A_HUMAN 34.361 227 128 5 6 228 5 214 3.56E-40 144 DNS2A_HUMAN reviewed Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) DNASE2 DNASE2A DNL2 Homo sapiens (Human) 360 apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; erythrocyte differentiation [GO:0030218] GO:0003677; GO:0004531; GO:0005764; GO:0006259; GO:0006309; GO:0030218; GO:0070062 0 0 0 PF03265; O00462 CHOYP_BRAFLDRAFT_65994.1.1 m.40535 sp MANBA_HUMAN 50.534 281 131 4 20 297 279 554 3.56E-91 291 MANBA_HUMAN reviewed Beta-mannosidase (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase) MANBA MANB1 Homo sapiens (Human) 879 carbohydrate metabolic process [GO:0005975]; cellular protein modification process [GO:0006464]; oligosaccharide catabolic process [GO:0009313] GO:0004567; GO:0005537; GO:0005975; GO:0006464; GO:0009313; GO:0043202; GO:0043231 PATHWAY: Glycan metabolism; N-glycan degradation. 0 0 PF02836; O70209 CHOYP_LOC100121771.1.1 m.6350 sp PDLI3_MOUSE 36.29 124 78 1 1 124 1 123 3.56E-18 89.7 PDLI3_MOUSE reviewed PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein) Pdlim3 Mus musculus (Mouse) 316 actin filament organization [GO:0007015]; heart development [GO:0007507] GO:0007015; GO:0007507; GO:0008092; GO:0008270; GO:0008307; GO:0015629; GO:0030018 0 0 0 PF15936;PF00412;PF00595; P18709 CHOYP_LS14A.3.3 m.12697 sp VITA2_XENLA 27.869 122 84 1 10 131 325 442 3.56E-06 50.4 VITA2_XENLA reviewed Vitellogenin-A2 (VTG A2) [Cleaved into: Lipovitellin I; Lipovitellin II; Phosvitin] 0 Xenopus laevis (African clawed frog) 1807 0 GO:0005319; GO:0045735 0 0 0 PF09172;PF09175;PF01347;PF00094; P55008 CHOYP_LOC100635694.1.1 m.24761 sp AIF1_HUMAN 58.741 143 59 0 6 148 5 147 3.56E-55 172 AIF1_HUMAN reviewed Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1) AIF1 G1 IBA1 Homo sapiens (Human) 147 "actin filament bundle assembly [GO:0051017]; actin filament polymerization [GO:0030041]; cellular response to extracellular stimulus [GO:0031668]; cellular response to hormone stimulus [GO:0032870]; cellular response to hydroperoxide [GO:0071447]; cellular response to interferon-gamma [GO:0071346]; cellular response to morphine [GO:0071315]; inflammatory response [GO:0006954]; microglial cell activation [GO:0001774]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell proliferation [GO:0048662]; phagocytosis, engulfment [GO:0006911]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of muscle hyperplasia [GO:0014739]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell migration [GO:2000406]; positive regulation of T cell proliferation [GO:0042102]; Rac protein signal transduction [GO:0016601]; response to axon injury [GO:0048678]; response to electrical stimulus [GO:0051602]; response to glucocorticoid [GO:0051384]; ruffle assembly [GO:0097178]" GO:0001774; GO:0001891; GO:0001934; GO:0005509; GO:0005634; GO:0005737; GO:0005829; GO:0005884; GO:0006911; GO:0006954; GO:0010629; GO:0014739; GO:0016601; GO:0030027; GO:0030041; GO:0031668; GO:0032587; GO:0032870; GO:0042102; GO:0043066; GO:0043204; GO:0045429; GO:0048471; GO:0048661; GO:0048662; GO:0048678; GO:0051015; GO:0051017; GO:0051384; GO:0051602; GO:0071315; GO:0071346; GO:0071447; GO:0071672; GO:0071673; GO:0090026; GO:0097178; GO:1900087; GO:2000406 0 0 0 0 P91924 CHOYP_LOC100637317.3.4 m.39364 sp ARF_DUGJA 58.289 187 73 3 1 187 1 182 3.56E-75 226 ARF_DUGJA reviewed ADP-ribosylation factor 0 Dugesia japonica (Planarian) 183 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q04832 CHOYP_EIF4BB.1.1 m.51065 sp HEXP_LEIMA 35.507 138 68 7 633 763 43 166 3.56E-07 56.2 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q06852 CHOYP_NEMVEDRAFT_V1G247993.1.1 m.50705 sp SLAP1_CLOTH 42.593 108 55 2 56 156 1550 1657 3.56E-09 57.8 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0E908 CHOYP_BRAFLDRAFT_69505.3.4 m.52485 sp HIL_DROME 27.778 468 307 9 61 516 333 781 3.56E-49 191 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q14162 CHOYP_MEG10.75.91 m.57526 sp SREC_HUMAN 34.392 189 109 8 179 366 252 426 3.56E-20 96.7 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q3T0Z7 CHOYP_LOC575893.1.1 m.62614 sp DHPR_BOVIN 61.039 231 89 1 4 234 8 237 3.56E-102 299 DHPR_BOVIN reviewed Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) QDPR Bos taurus (Bovine) 242 tetrahydrobiopterin biosynthetic process [GO:0006729] GO:0004155; GO:0005739; GO:0006729; GO:0070062 0 0 0 PF00106; Q3T100 CHOYP_ISCW_ISCW012228.1.2 m.57884 sp MGST3_BOVIN 50 134 64 1 11 141 4 137 3.56E-40 135 MGST3_BOVIN reviewed Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) MGST3 Bos taurus (Bovine) 152 0 GO:0004364; GO:0004602; GO:0005635; GO:0005783; GO:0005789; GO:0016021; GO:0031090; GO:0070062 0 0 0 PF01124; Q3U492 CHOYP_BRAFLDRAFT_74063.4.5 m.43367 sp KCP_MOUSE 26.978 493 224 27 26 421 487 940 3.56E-15 81.6 KCP_MOUSE reviewed Kielin/chordin-like protein (Cysteine-rich BMP regulator 2) (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin/chordin-like protein 1) (KCP-1) Kcp Crim2 Kcp1 Mus musculus (Mouse) 1550 hematopoietic progenitor cell differentiation [GO:0002244]; positive regulation of BMP signaling pathway [GO:0030513] GO:0002244; GO:0005615; GO:0030513 0 0 0 PF00093;PF00094; Q5M9B1 CHOYP_LOC100368794.1.1 m.11160 sp SPSB3_XENLA 35.211 213 128 6 20 228 105 311 3.56E-32 123 SPSB3_XENLA reviewed SPRY domain-containing SOCS box protein 3 (SSB-3) spsb3 Xenopus laevis (African clawed frog) 360 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07525;PF00622; Q6AYH2 CHOYP_INO80E.1.1 m.56862 sp IN80E_RAT 64.13 92 27 2 14 99 8 99 3.56E-26 104 IN80E_RAT reviewed INO80 complex subunit E (Coiled-coil domain-containing protein 95) Ino80e Ccdc95 Rattus norvegicus (Rat) 244 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006260; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0031011 0 0 0 0 Q6AYH2 CHOYP_LOC100186361.1.3 m.17827 sp IN80E_RAT 64.13 92 27 2 14 99 8 99 3.56E-26 104 IN80E_RAT reviewed INO80 complex subunit E (Coiled-coil domain-containing protein 95) Ino80e Ccdc95 Rattus norvegicus (Rat) 244 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006260; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0031011 0 0 0 0 Q6NRH3 CHOYP_BRAFLDRAFT_91063.1.1 m.51548 sp CC149_XENLA 49.832 297 140 6 7 300 1 291 3.56E-81 266 CC149_XENLA reviewed Coiled-coil domain-containing protein 149 ccdc149 Xenopus laevis (African clawed frog) 516 0 0 0 0 0 PF09789; Q6P2Z3 CHOYP_BRAFLDRAFT_251612.1.1 m.28186 sp FOXI1_XENTR 42.361 144 76 4 210 346 124 267 3.56E-26 112 FOXI1_XENTR reviewed Forkhead box protein I1 (FoxI1) foxi1 TGas064e18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 363 "cell differentiation [GO:0030154]; determination of ventral identity [GO:0048264]; ectoderm development [GO:0007398]; nervous system development [GO:0007399]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0005634; GO:0006351; GO:0007398; GO:0007399; GO:0030154; GO:0043565; GO:0045893; GO:0048264 0 0 0 PF00250; Q6P3N5 CHOYP_LOC100368756.1.1 m.9490 sp CNIH4_XENTR 53.237 139 65 0 18 156 1 139 3.56E-54 171 CNIH4_XENTR reviewed Protein cornichon homolog 4 (CNIH-4) (Cornichon family AMPA receptor auxiliary protein 4) cnih4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 139 ER to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] GO:0005783; GO:0005793; GO:0006888; GO:0015031; GO:0016021 0 0 0 PF03311; Q6P9X4 CHOYP_ISCW_ISCW015996.1.1 m.24456 sp TP4A2_RAT 69.277 166 48 2 8 172 3 166 3.56E-81 240 TP4A2_RAT reviewed Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) Ptp4a2 Prl2 Rattus norvegicus (Rat) 167 0 GO:0004725; GO:0005634; GO:0005737; GO:0005769; GO:0005886; GO:0070062 0 0 0 PF00102; Q6ZV65 CHOYP_LOC100370211.1.1 m.55415 sp FA47E_HUMAN 27.39 387 237 10 33 418 16 359 3.56E-28 119 FA47E_HUMAN reviewed Protein FAM47E FAM47E Homo sapiens (Human) 393 0 0 0 0 0 PF14642; Q75J93 CHOYP_BRAFLDRAFT_125403.1.1 m.30476 sp CPAS1_DICDI 32.818 841 501 17 39 869 54 840 3.56E-127 405 CPAS1_DICDI reviewed Circularly permutated Ras protein 1 (DdiCPRas1) cpras1 DDB_G0277381 Dictyostelium discoideum (Slime mold) 842 ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0006886; GO:0006888; GO:0007264; GO:0008270; GO:0030127 0 0 0 PF00071; Q8CDF7 CHOYP_LOC100902998.2.2 m.55385 sp EXD1_MOUSE 34.839 155 92 6 26 175 152 302 3.56E-14 78.2 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q8IVI9 CHOYP_BRAFLDRAFT_79602.1.1 m.42298 sp NOSTN_HUMAN 30.242 496 327 7 66 556 14 495 3.56E-66 226 NOSTN_HUMAN reviewed Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) NOSTRIN Homo sapiens (Human) 506 "endocytosis [GO:0006897]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of nitric-oxide synthase activity [GO:0050999]; signal transduction [GO:0007165]" GO:0003677; GO:0005634; GO:0005856; GO:0005886; GO:0006897; GO:0007165; GO:0030666; GO:0045892; GO:0050999 0 0 0 PF00611;PF14604; Q91YD4 CHOYP_TRPM2.10.12 m.58307 sp TRPM2_MOUSE 26.094 640 363 23 386 965 486 1075 3.56E-42 172 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q969X6 CHOYP_LOC100180054.1.1 m.13172 sp UTP4_HUMAN 42.574 303 168 3 11 308 1 302 3.56E-80 261 UTP4_HUMAN reviewed U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component) UTP4 CIRH1A cPERP-E KIAA1988 Homo sapiens (Human) 686 "maturation of SSU-rRNA [GO:0030490]; regulation of transcription, DNA-templated [GO:0006355]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0001650; GO:0005654; GO:0005694; GO:0005730; GO:0006351; GO:0006355; GO:0006364; GO:0030490; GO:0034455; GO:0044822 0 0 0 PF00400; Q96T23 CHOYP_SI_DKEY-21N12.1.1.1 m.65205 sp RSF1_HUMAN 45.789 190 96 2 18 201 21 209 3.56E-50 201 RSF1_HUMAN reviewed Remodeling and spacing factor 1 (Rsf-1) (HBV pX-associated protein 8) (Hepatitis B virus X-associated protein) (p325 subunit of RSF chromatin-remodeling complex) RSF1 HBXAP XAP8 Homo sapiens (Human) 1441 "CENP-A containing nucleosome assembly [GO:0034080]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; DNA-templated transcription, initiation [GO:0006352]; negative regulation of DNA binding [GO:0043392]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of viral transcription [GO:0050434]" GO:0005634; GO:0005654; GO:0006334; GO:0006338; GO:0006352; GO:0008270; GO:0016569; GO:0016584; GO:0031213; GO:0034080; GO:0042393; GO:0043392; GO:0045892; GO:0045893; GO:0050434 0 0 0 PF00628;PF15612; Q99315 CHOYP_LOC100369720.1.1 m.57251 sp YG31B_YEAST 24.289 457 315 14 646 1093 574 1008 3.56E-24 115 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9BXJ4 CHOYP_LOC100693735.2.2 m.61011 sp C1QT3_HUMAN 33.962 106 67 2 56 160 118 221 3.56E-09 57.8 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9D3S3 CHOYP_SNX29.1.1 m.59905 sp SNX29_MOUSE 45.886 316 170 1 432 747 465 779 3.56E-88 299 SNX29_MOUSE reviewed Sorting nexin-29 Snx29 Mus musculus (Mouse) 818 0 GO:0035091; GO:0070062 0 0 0 PF00787;PF02759; Q9DGD1 CHOYP_LOC100372236.2.4 m.42989 sp MGT4C_CHICK 30.661 499 304 12 1 495 1 461 3.56E-81 263 MGT4C_CHICK reviewed "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.-) (EC 2.4.1.145) (N-acetylglucosaminyltransferase VI) (GnT-VI) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Gallus gallus (Chicken) 464 N-glycan processing [GO:0006491] GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04666; A2RU49 CHOYP_DVIR_GJ17679.2.3 m.46443 sp HYKK_HUMAN 34.933 375 221 8 16 386 14 369 3.57E-64 212 HYKK_HUMAN reviewed Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) HYKK AGPHD1 Homo sapiens (Human) 373 lysine catabolic process [GO:0006554] GO:0005759; GO:0006554; GO:0047992 0 0 0 PF01636; A9CPT4 CHOYP_BRAFLDRAFT_125037.3.3 m.48700 sp TDRD1_ORYLA 24.08 897 577 28 592 1399 123 1004 3.57E-47 189 TDRD1_ORYLA reviewed Tudor domain-containing protein 1 tdrd1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 1133 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0007275; GO:0007281; GO:0007283; GO:0031047; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; B5X8M4 CHOYP_BRCC3.1.1 m.66615 sp BRCC3_SALSA 64.4 250 86 2 10 259 1 247 3.57E-119 344 BRCC3_SALSA reviewed Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) brcc3 brcc36 Salmo salar (Atlantic salmon) 260 cell division [GO:0051301]; double-strand break repair [GO:0006302]; G2 DNA damage checkpoint [GO:0031572]; histone H2A K63-linked deubiquitination [GO:0070537]; mitotic nuclear division [GO:0007067]; positive regulation of DNA repair [GO:0045739]; protein K63-linked deubiquitination [GO:0070536]; response to ionizing radiation [GO:0010212] GO:0000922; GO:0004843; GO:0005634; GO:0005737; GO:0006302; GO:0007067; GO:0008237; GO:0010212; GO:0031572; GO:0031593; GO:0045739; GO:0046872; GO:0051301; GO:0070531; GO:0070536; GO:0070537; GO:0070552 0 0 0 PF01398; P04464 CHOYP_CALM.20.50 m.30951 sp CALM_WHEAT 35.338 133 74 6 61 187 21 147 3.57E-13 67 CALM_WHEAT reviewed Calmodulin (CaM) 0 Triticum aestivum (Wheat) 149 0 GO:0005509 0 0 0 PF13499; P10746 CHOYP_LOC496102.1.1 m.31296 sp HEM4_HUMAN 33.663 101 59 4 3 99 161 257 3.57E-08 52.4 HEM4_HUMAN reviewed Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) UROS Homo sapiens (Human) 265 cellular response to amine stimulus [GO:0071418]; cellular response to arsenic-containing substance [GO:0071243]; heme biosynthetic process [GO:0006783]; protoporphyrinogen IX biosynthetic process [GO:0006782]; response to antibiotic [GO:0046677]; uroporphyrinogen III biosynthetic process [GO:0006780] GO:0004852; GO:0005739; GO:0005829; GO:0006780; GO:0006782; GO:0006783; GO:0046677; GO:0048037; GO:0071243; GO:0071418 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4. 0 cd06578; PF02602; P11678 CHOYP_PHUM_PHUM027580.1.1 m.44625 sp PERE_HUMAN 44.615 130 63 3 90 212 145 272 3.57E-25 106 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P18433 CHOYP_PTPRT.9.45 m.34316 sp PTPRA_HUMAN 30.246 691 425 23 401 1057 133 800 3.57E-80 282 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P26270 CHOYP_PSD7.1.1 m.19729 sp PSMD7_DROME 78.618 304 62 2 9 311 8 309 3.57E-172 486 PSMD7_DROME reviewed 26S proteasome non-ATPase regulatory subunit 7 (26S proteasome regulatory subunit RPN8) (26S proteasome regulatory subunit S12) (Proteasome subunit p39B) (Proteasome subunit p40) (Protein Mov34) Rpn8 Mov34 CG3416 Drosophila melanogaster (Fruit fly) 338 cell proliferation [GO:0008283]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0000022; GO:0000502; GO:0005838; GO:0007052; GO:0008283; GO:0008541; GO:0022008; GO:0030425; GO:0043161 0 0 0 PF01398;PF13012; P70031 CHOYP_CCKAR.3.6 m.42675 sp CCKAR_XENLA 39.623 371 198 5 15 365 60 424 3.57E-84 267 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; P86854 CHOYP_NEMVEDRAFT_V1G238062.5.6 m.30588 sp PLCL_MYTGA 30.303 132 82 4 1 126 4 131 3.57E-16 74.7 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q09654 CHOYP_LOC100374741.8.83 m.8075 sp TRI23_CAEEL 26.442 208 120 9 24 209 118 314 3.57E-06 52.4 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q11212 CHOYP_ACT.7.27 m.15795 sp ACT_SPOLI 70.946 148 1 1 1 148 44 149 3.57E-66 201 ACT_SPOLI reviewed Actin (Fragment) 0 Spodoptera littoralis (Egyptian cotton leafworm) 164 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q2T9W6 CHOYP_LRRF2.2.2 m.40846 sp LRRF2_BOVIN 45.854 410 192 10 2 394 3 399 3.57E-81 257 LRRF2_BOVIN reviewed Leucine-rich repeat flightless-interacting protein 2 (LRR FLII-interacting protein 2) LRRFIP2 Bos taurus (Bovine) 400 "regulation of transcription, DNA-templated [GO:0006355]; Wnt signaling pathway [GO:0016055]" GO:0006355; GO:0016055 0 0 0 PF09738; Q3MHQ4 CHOYP_ESCA.1.1 m.10318 sp SNAI2_BOVIN 78.322 143 30 1 261 402 124 266 3.57E-77 243 SNAI2_BOVIN reviewed Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2) SNAI2 SLUG Bos taurus (Bovine) 268 "canonical Wnt signaling pathway [GO:0060070]; cartilage morphogenesis [GO:0060536]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to ionizing radiation [GO:0071479]; desmosome disassembly [GO:0035921]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; epithelium development [GO:0060429]; negative regulation of anoikis [GO:2000811]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catenin import into nucleus [GO:0035414]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter [GO:1900387]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of vitamin D biosynthetic process [GO:0010957]; negative regulation of vitamin D receptor signaling pathway [GO:0070563]; neural crest cell development [GO:0014032]; Notch signaling pathway [GO:0007219]; osteoblast differentiation [GO:0001649]; palate development [GO:0060021]; pigmentation [GO:0043473]; positive regulation of cell migration [GO:0030335]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of histone acetylation [GO:0035066]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]; regulation of chemokine production [GO:0032642]; regulation of osteoblast differentiation [GO:0045667]; sensory perception of sound [GO:0007605]; transcription, DNA-templated [GO:0006351]; white fat cell differentiation [GO:0050872]" GO:0000790; GO:0001078; GO:0001649; GO:0003198; GO:0003273; GO:0003682; GO:0003705; GO:0005634; GO:0005737; GO:0006351; GO:0006933; GO:0007219; GO:0007605; GO:0010839; GO:0010957; GO:0014032; GO:0030335; GO:0032331; GO:0032642; GO:0035066; GO:0035414; GO:0035921; GO:0043473; GO:0043518; GO:0043565; GO:0045600; GO:0045667; GO:0046872; GO:0050872; GO:0060021; GO:0060070; GO:0060429; GO:0060536; GO:0060693; GO:0070563; GO:0071364; GO:0071479; GO:0090090; GO:1900387; GO:1902230; GO:2000647; GO:2000810; GO:2000811; GO:2001240 0 0 0 PF00096;PF13912; Q3ZBX1 CHOYP_LOC587900.1.1 m.64540 sp PIGC_BOVIN 48.763 283 141 1 1 283 13 291 3.57E-91 275 PIGC_BOVIN reviewed Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C) PIGC Bos taurus (Bovine) 297 GPI anchor biosynthetic process [GO:0006506] GO:0000506; GO:0003824; GO:0005789; GO:0006506; GO:0016021; GO:0017176 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF06432; Q4R7M4 CHOYP_BRAFLDRAFT_94079.1.1 m.57532 sp DTWD2_MACFA 47.162 229 119 1 59 285 62 290 3.57E-68 217 DTWD2_MACFA reviewed DTW domain-containing protein 2 DTWD2 QtsA-14809 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 298 0 0 0 0 0 PF03942; Q503L9 CHOYP_LOC100633077.4.4 m.62658 sp NXN_DANRE 51.402 107 52 0 28 134 177 283 3.57E-35 129 NXN_DANRE reviewed Nucleoredoxin (EC 1.8.1.8) nxn zgc:110449 Danio rerio (Zebrafish) (Brachydanio rerio) 418 cardiovascular system development [GO:0072358]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005829; GO:0016055; GO:0030154; GO:0030178; GO:0031397; GO:0045454; GO:0047134; GO:0072358 0 0 0 PF13905; Q56AP7 CHOYP_BRAFLDRAFT_213715.1.1 m.41051 sp CRBN_RAT 40 75 44 1 83 156 352 426 3.57E-14 72.4 CRBN_RAT reviewed Protein cereblon Crbn Rattus norvegicus (Rat) 445 negative regulation of ion transmembrane transport [GO:0034766]; negative regulation of protein homooligomerization [GO:0032463]; positive regulation of protein homodimerization activity [GO:0090073]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] GO:0004176; GO:0005634; GO:0005730; GO:0005737; GO:0016020; GO:0016567; GO:0031464; GO:0032463; GO:0034766; GO:0043161; GO:0046872; GO:0090073 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96SW2}. 0 0 PF02190;PF03226; Q5RCU5 CHOYP_LOC100752270.1.1 m.23081 sp CBR1_PONAB 52.766 235 110 1 4 237 43 277 3.57E-91 273 CBR1_PONAB reviewed Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) CBR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 277 drug metabolic process [GO:0017144]; vitamin K metabolic process [GO:0042373] GO:0004090; GO:0005737; GO:0017144; GO:0042373; GO:0047021; GO:0050221 0 0 0 PF00106; Q6AXY7 CHOYP_LOC100875404.1.1 m.8506 sp PR38B_RAT 77.202 193 44 0 5 197 45 237 3.57E-105 325 PR38B_RAT reviewed Pre-mRNA-splicing factor 38B Prpf38b Rattus norvegicus (Rat) 542 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0006397; GO:0008380; GO:0044822; GO:0071011 0 0 0 PF03371; Q6NW85 CHOYP_ARI1.1.1 m.51550 sp ARI1L_DANRE 30.83 253 139 10 493 734 158 385 3.57E-20 99 ARI1L_DANRE reviewed E3 ubiquitin-protein ligase arih1l (EC 6.3.2.-) arih1l zgc:85905 Danio rerio (Zebrafish) (Brachydanio rerio) 533 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0016874; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; Q6P5J6 CHOYP_BRAFLDRAFT_70490.1.1 m.15742 sp LRC42_DANRE 40.278 72 38 2 25 95 77 144 3.57E-07 50.1 LRC42_DANRE reviewed Leucine-rich repeat-containing protein 42 lrrc42 si:dkey-181m9.2 Danio rerio (Zebrafish) (Brachydanio rerio) 407 0 0 0 0 0 0 Q6PFY8 CHOYP_LOC100374819.3.7 m.53908 sp TRI45_MOUSE 26.339 224 148 6 8 222 127 342 3.57E-11 69.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6UVM3 CHOYP_AGAP_AGAP007585.1.1 m.66144 sp KCNT2_HUMAN 52.923 325 123 4 18 342 18 312 3.57E-115 362 KCNT2_HUMAN reviewed Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1) KCNT2 SLICK Homo sapiens (Human) 1135 0 GO:0005249; GO:0005524; GO:0008076; GO:0015269 0 0 0 PF03493;PF07885; Q80YX1 CHOYP_BRAFLDRAFT_96226.1.2 m.36150 sp TENA_MOUSE 39.091 110 64 2 1 110 1993 2099 3.57E-19 84.3 TENA_MOUSE reviewed Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) 2110 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] GO:0001649; GO:0001968; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; Q8CB77 CHOYP_LOC100698273.1.1 m.17652 sp ELOA1_MOUSE 44.131 213 114 3 639 850 486 694 3.57E-52 199 ELOA1_MOUSE reviewed Transcription elongation factor B polypeptide 3 (Elongin 110 kDa subunit) (Elongin-A) (EloA) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) Tceb3 Mus musculus (Mouse) 773 regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368] GO:0003677; GO:0005615; GO:0006357; GO:0006368; GO:0016021; GO:0070449 0 0 0 PF06881;PF08711; Q8N2E2 CHOYP_LOC101240164.1.1 m.28169 sp VWDE_HUMAN 25.333 300 203 5 1021 1305 795 1088 3.57E-22 108 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TDB6 CHOYP_LOC101067833.2.3 m.25528 sp DTX3L_HUMAN 50 202 97 2 401 602 542 739 3.57E-57 208 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q92038 CHOYP_ACOD.7.8 m.59271 sp ACOD_CYPCA 66.977 215 70 1 2 215 109 323 3.57E-102 301 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; Q9NZJ4 CHOYP_BRAFLDRAFT_67666.6.6 m.57558 sp SACS_HUMAN 26.043 1774 1110 54 16 1655 2076 3781 3.57E-142 493 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; A4IF63 CHOYP_LOC101163547.3.3 m.52721 sp TRIM2_BOVIN 25.676 148 107 1 2 149 599 743 3.58E-09 59.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B0BLT4 CHOYP_PKHA8.1.1 m.43806 sp GLTP_XENTR 37.209 86 49 2 18 98 15 100 3.58E-10 57.4 GLTP_XENTR reviewed Glycolipid transfer protein (GLTP) gltp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 209 0 GO:0005737; GO:0017089; GO:0051861 0 0 0 PF08718; D3YXG0 CHOYP_PHUM_PHUM068980.5.5 m.61005 sp HMCN1_MOUSE 26.667 375 218 18 253 594 2786 3136 3.58E-13 77.8 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; H2A0N9 CHOYP_LOC100204502.1.2 m.26864 sp KCP4_PINMG 40.845 71 27 1 27 97 90 145 3.58E-08 52 KCP4_PINMG reviewed BPTI/Kunitz domain-containing protein 4 (Nacre serine protease inhibitor 3) (NSPI3) 0 Pinctada margaritifera (Black-lipped pearl oyster) 198 0 GO:0004867; GO:0005576 0 0 0 PF02822;PF00014; H2A0N9 CHOYP_LOC100204502.2.2 m.30087 sp KCP4_PINMG 40.845 71 27 1 27 97 90 145 3.58E-08 52 KCP4_PINMG reviewed BPTI/Kunitz domain-containing protein 4 (Nacre serine protease inhibitor 3) (NSPI3) 0 Pinctada margaritifera (Black-lipped pearl oyster) 198 0 GO:0004867; GO:0005576 0 0 0 PF02822;PF00014; O00148 CHOYP_DX39B.3.3 m.49060 sp DX39A_HUMAN 72.897 107 29 0 1 107 320 426 3.58E-54 177 DX39A_HUMAN reviewed ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) DDX39A DDX39 Homo sapiens (Human) 427 "cellular response to DNA damage stimulus [GO:0006974]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; regulation of gene expression [GO:0010468]; RNA export from nucleus [GO:0006405]; RNA secondary structure unwinding [GO:0010501]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000398; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006369; GO:0006405; GO:0006406; GO:0006974; GO:0010468; GO:0010501; GO:0016020; GO:0016887; GO:0031124; GO:0044822 0 0 0 PF00270;PF00271; O75030 CHOYP_LOC100856330.1.1 m.30068 sp MITF_HUMAN 50.467 107 53 0 183 289 299 405 3.58E-27 118 MITF_HUMAN reviewed Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) MITF BHLHE32 Homo sapiens (Human) 526 "mast cell migration [GO:0097531]; melanocyte differentiation [GO:0030318]; multicellular organism development [GO:0007275]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein complex assembly [GO:0006461]; protein sumoylation [GO:0016925]; regulation of apoptotic process [GO:0042981]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000122; GO:0000978; GO:0001077; GO:0001227; GO:0005634; GO:0005654; GO:0006355; GO:0006461; GO:0007275; GO:0010628; GO:0016925; GO:0030318; GO:0042981; GO:0043234; GO:0045670; GO:0045893; GO:0045944; GO:0097531; GO:2000144; GO:2001141 0 0 0 PF11851;PF00010;PF15951; O88898 CHOYP_LOC100313697.1.1 m.23210 sp P63_MOUSE 47.774 337 153 9 15 333 105 436 3.58E-91 290 P63_MOUSE reviewed Tumor protein 63 (p63) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) Tp63 P63 P73l Tp73l Trp63 Mus musculus (Mouse) 680 "anatomical structure formation involved in morphogenesis [GO:0048646]; apoptotic process [GO:0006915]; cell aging [GO:0007569]; cell differentiation [GO:0030154]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; cloacal septation [GO:0060197]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; ectoderm and mesoderm interaction [GO:0007499]; embryonic limb morphogenesis [GO:0030326]; epidermal cell division [GO:0010481]; epidermis development [GO:0008544]; epithelial cell development [GO:0002064]; epithelial cell differentiation [GO:0030855]; establishment of planar polarity [GO:0001736]; establishment of skin barrier [GO:0061436]; female genitalia morphogenesis [GO:0048807]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; mitotic G1 DNA damage checkpoint [GO:0031571]; morphogenesis of a polarized epithelium [GO:0001738]; multicellular organism aging [GO:0010259]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of keratinocyte differentiation [GO:0045617]; negative regulation of mesoderm development [GO:2000381]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron apoptotic process [GO:0051402]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; organ morphogenesis [GO:0009887]; pattern specification process [GO:0007389]; polarized epithelial cell differentiation [GO:0030859]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of keratinocyte proliferation [GO:0010838]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-anal tail morphogenesis [GO:0036342]; prostate gland development [GO:0030850]; prostatic bud formation [GO:0060513]; protein homotetramerization [GO:0051289]; proximal/distal pattern formation [GO:0009954]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of epidermal cell division [GO:0010482]; regulation of neuron apoptotic process [GO:0043523]; replicative cell aging [GO:0001302]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; skeletal system development [GO:0001501]; skin morphogenesis [GO:0043589]; smooth muscle tissue development [GO:0048745]; spermatogenesis [GO:0007283]; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [GO:0060529]; sympathetic nervous system development [GO:0048485]; urinary bladder development [GO:0060157]" GO:0000122; GO:0000785; GO:0000790; GO:0000989; GO:0001077; GO:0001302; GO:0001501; GO:0001736; GO:0001738; GO:0001942; GO:0002039; GO:0002053; GO:0002064; GO:0003677; GO:0003682; GO:0003684; GO:0003690; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005791; GO:0005829; GO:0006338; GO:0006915; GO:0006978; GO:0007219; GO:0007275; GO:0007283; GO:0007389; GO:0007499; GO:0007569; GO:0008544; GO:0009887; GO:0009954; GO:0010165; GO:0010259; GO:0010332; GO:0010481; GO:0010482; GO:0010838; GO:0030154; GO:0030216; GO:0030326; GO:0030425; GO:0030850; GO:0030855; GO:0030859; GO:0031069; GO:0031571; GO:0034644; GO:0036342; GO:0042475; GO:0042771; GO:0042802; GO:0043066; GO:0043281; GO:0043523; GO:0043565; GO:0043589; GO:0043616; GO:0044212; GO:0045617; GO:0045669; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0046872; GO:0048485; GO:0048646; GO:0048745; GO:0048807; GO:0050699; GO:0051289; GO:0051402; GO:0060157; GO:0060197; GO:0060513; GO:0060529; GO:0061436; GO:1902808; GO:2000271; GO:2000381; GO:2000773; GO:2001235 0 0 cd08367; PF00870;PF07710;PF07647; P02707 CHOYP_LOC100368595.3.3 m.66197 sp LECH_CHICK 35.156 128 80 3 306 431 78 204 3.58E-21 94.4 LECH_CHICK reviewed Hepatic lectin 0 Gallus gallus (Chicken) 207 endocytosis [GO:0006897] GO:0006897; GO:0016021; GO:0030246 0 0 0 PF00059; P10076 CHOYP_ZNF99.2.3 m.34209 sp ZFP26_MOUSE 29.327 416 231 17 455 842 383 763 3.58E-35 148 ZFP26_MOUSE reviewed Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) 861 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; P14318 CHOYP_LOC100901546.1.1 m.26075 sp MP20_DROME 51.376 109 45 2 3 103 73 181 3.58E-26 98.6 MP20_DROME reviewed Muscle-specific protein 20 Mp20 Tpn CG4696 Drosophila melanogaster (Fruit fly) 184 cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739] GO:0003779; GO:0007155; GO:0007520; GO:0008360; GO:1901739 0 0 0 PF00402;PF00307; P14318 CHOYP_LOC101077059.1.1 m.57293 sp MP20_DROME 51.376 109 45 2 3 103 73 181 3.58E-26 98.6 MP20_DROME reviewed Muscle-specific protein 20 Mp20 Tpn CG4696 Drosophila melanogaster (Fruit fly) 184 cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739] GO:0003779; GO:0007155; GO:0007520; GO:0008360; GO:1901739 0 0 0 PF00402;PF00307; P15771 CHOYP_RPL36.1.1 m.57199 sp NUCL_CHICK 34.45 209 117 4 149 356 358 547 3.58E-25 111 NUCL_CHICK reviewed Nucleolin (Protein C23) NCL Gallus gallus (Chicken) 694 0 GO:0000166; GO:0003677; GO:0003723; GO:0005730 0 0 0 PF00076; P16157 CHOYP_TVAG_168010.9.45 m.32986 sp ANK1_HUMAN 35.862 290 186 0 6 295 206 495 3.58E-49 179 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18433 CHOYP_BRAFLDRAFT_59175.1.2 m.42350 sp PTPRA_HUMAN 29.652 489 318 13 1 470 316 797 3.58E-59 211 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P24386 CHOYP_LOC100891770.1.1 m.30262 sp RAE1_HUMAN 34.389 221 134 5 1 214 399 615 3.58E-34 134 RAE1_HUMAN reviewed Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) CHM REP1 TCD Homo sapiens (Human) 653 protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; regulation of apoptotic process [GO:0042981]; small GTPase mediated signal transduction [GO:0007264]; visual perception [GO:0007601] GO:0004663; GO:0005092; GO:0005096; GO:0005829; GO:0005968; GO:0006612; GO:0007264; GO:0007601; GO:0016491; GO:0017137; GO:0018344; GO:0042981 0 0 0 PF00996; P42893 CHOYP_ECE2.1.1 m.57654 sp ECE1_RAT 30.897 780 453 15 69 824 45 762 3.58E-119 381 ECE1_RAT reviewed Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) Ece1 Rattus norvegicus (Rat) 762 apoptotic process [GO:0006915]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of blood pressure [GO:0008217]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of vasodilation [GO:0042312]; response to cadmium ion [GO:0046686]; response to drug [GO:0042493]; response to hypoxia [GO:0001666]; response to muscle stretch [GO:0035994] GO:0001666; GO:0001921; GO:0004222; GO:0005769; GO:0005886; GO:0006508; GO:0006915; GO:0008217; GO:0009897; GO:0010613; GO:0016020; GO:0016021; GO:0016485; GO:0030141; GO:0030819; GO:0031410; GO:0031982; GO:0035994; GO:0042312; GO:0042493; GO:0042803; GO:0045745; GO:0046686; GO:0046872; GO:0070372 0 0 cd08662; PF01431;PF05649; P55112 CHOYP_NAS4.1.1 m.26788 sp NAS4_CAEEL 40.323 248 135 5 27 264 45 289 3.58E-47 173 NAS4_CAEEL reviewed Zinc metalloproteinase nas-4 (EC 3.4.24.21) (Nematode astacin 4) nas-4 C05D11.6 Caenorhabditis elegans 315 0 GO:0004222; GO:0005576; GO:0008270 0 0 0 PF01400; P56719 CHOYP_HCRTR2.1.1 m.45845 sp OX2R_RAT 38.053 113 66 2 5 113 296 408 3.58E-16 77 OX2R_RAT reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0004930; GO:0005887; GO:0007186; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P86854 CHOYP_BRAFLDRAFT_208160.1.2 m.4498 sp PLCL_MYTGA 23.602 161 110 2 10 170 1 148 3.58E-12 64.3 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P86854 CHOYP_FASN.4.4 m.66456 sp PLCL_MYTGA 21.547 181 107 4 3 181 9 156 3.58E-08 53.5 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P98158 CHOYP_HSPG2.1.4 m.1496 sp LRP2_RAT 41.411 326 165 10 745 1047 3553 3875 3.58E-53 208 LRP2_RAT reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) 4660 aging [GO:0007568]; endosomal transport [GO:0016197]; hemoglobin import [GO:0020028]; hormone secretion [GO:0046879]; lipoprotein transport [GO:0042953]; negative regulation of endopeptidase activity [GO:0010951]; organ regeneration [GO:0031100]; receptor-mediated endocytosis [GO:0006898]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; transcytosis [GO:0045056]; vitamin metabolic process [GO:0006766] GO:0004872; GO:0005509; GO:0005615; GO:0005737; GO:0005768; GO:0005903; GO:0005905; GO:0006766; GO:0006898; GO:0007568; GO:0010165; GO:0010951; GO:0016020; GO:0016021; GO:0016197; GO:0016324; GO:0020028; GO:0030165; GO:0030492; GO:0031100; GO:0031526; GO:0032403; GO:0032526; GO:0033280; GO:0042493; GO:0042562; GO:0042953; GO:0043234; GO:0045056; GO:0045121; GO:0046879; GO:0050750 0 0 0 PF12662;PF07645;PF00057;PF00058; Q0VB26 CHOYP_BRAFLDRAFT_117083.2.3 m.46593 sp TEX26_MOUSE 23.377 231 174 3 116 345 49 277 3.58E-12 70.1 TEX26_MOUSE reviewed Testis-expressed sequence 26 protein Tex26 Mus musculus (Mouse) 296 0 0 0 0 0 0 Q14517 CHOYP_FAT4.8.10 m.44748 sp FAT1_HUMAN 25.341 1614 1050 65 42 1595 2093 3611 3.58E-73 276 FAT1_HUMAN reviewed "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; single organismal cell-cell adhesion [GO:0016337] GO:0005509; GO:0005634; GO:0005886; GO:0005887; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016337; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q26626 CHOYP_KIFA3.1.1 m.26224 sp KIFA3_STRPU 39.726 73 37 3 2 68 727 798 3.58E-06 47.4 KIFA3_STRPU reviewed Kinesin-associated protein 3 (SpKAP115) KAP115 Strongylocentrotus purpuratus (Purple sea urchin) 828 microtubule-based process [GO:0007017] GO:0007017; GO:0016939 0 0 0 0 Q54P70 CHOYP_MYBV.1.1 m.62683 sp Y4757_DICDI 30.435 138 88 4 456 591 634 765 3.58E-11 71.6 Y4757_DICDI reviewed OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) 766 0 GO:0008234 0 0 0 PF02338; Q5RBQ7 CHOYP_CDO1.3.4 m.46087 sp CDO1_PONAB 43.182 176 94 1 23 198 27 196 3.58E-44 148 CDO1_PONAB reviewed Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) CDO1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 200 taurine biosynthetic process [GO:0042412] GO:0005506; GO:0005829; GO:0017172; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. 0 0 PF05995; Q6AXU6 CHOYP_LOC101157371.3.3 m.51109 sp HN1_RAT 50 54 26 1 1 53 1 54 3.58E-06 47.8 HN1_RAT reviewed "Hematological and neurological expressed 1 protein [Cleaved into: Hematological and neurological expressed 1 protein, N-terminally processed]" Hn1 Rattus norvegicus (Rat) 149 0 GO:0005730; GO:0031965 0 0 0 PF17054; Q6PFY8 CHOYP_TRI45.4.23 m.3971 sp TRI45_MOUSE 28.636 220 151 3 21 235 103 321 3.58E-17 83.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7Z5Y7 CHOYP_LOC657718.1.1 m.8334 sp KCD20_HUMAN 65.541 296 100 2 119 413 101 395 3.58E-142 416 KCD20_HUMAN reviewed BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20) KCTD20 C6orf69 Homo sapiens (Human) 419 positive regulation of phosphorylation [GO:0042327] GO:0005737; GO:0042327 0 0 0 0 Q7Z6K3 CHOYP_LOC100368556.1.1 m.7503 sp PTAR1_HUMAN 39.296 341 147 3 34 348 14 320 3.58E-80 255 PTAR1_HUMAN reviewed Protein prenyltransferase alpha subunit repeat-containing protein 1 PTAR1 Homo sapiens (Human) 402 protein prenylation [GO:0018342] GO:0005737; GO:0008318; GO:0018342; GO:1990234 0 0 0 PF01239; Q8C4B4 CHOYP_BRAFLDRAFT_89535.1.1 m.6232 sp U119B_MOUSE 60.714 224 78 2 7 220 27 250 3.58E-98 288 U119B_MOUSE reviewed Protein unc-119 homolog B Unc119b Mus musculus (Mouse) 251 cilium morphogenesis [GO:0060271]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031] GO:0008289; GO:0015031; GO:0035869; GO:0042953; GO:0060271 0 0 0 PF05351; Q8IWB9 CHOYP_TEX2.1.1 m.56485 sp TEX2_HUMAN 35.952 662 343 12 279 887 471 1104 3.58E-108 362 TEX2_HUMAN reviewed Testis-expressed sequence 2 protein (Transmembrane protein 96) TEX2 KIAA1738 TMEM96 Homo sapiens (Human) 1127 signal transduction [GO:0007165]; sphingolipid metabolic process [GO:0006665] GO:0005783; GO:0006665; GO:0007165; GO:0008289; GO:0016021 0 0 0 0 Q8R003 CHOYP_LOC101079701.1.1 m.37761 sp MBNL3_MOUSE 65.432 81 28 0 3 83 177 257 3.58E-35 126 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q8VC31 CHOYP_LOC100492683.1.1 m.63753 sp CCDC9_MOUSE 44.737 114 57 2 335 446 186 295 3.58E-19 95.9 CCDC9_MOUSE reviewed Coiled-coil domain-containing protein 9 Ccdc9 Mus musculus (Mouse) 543 0 GO:0044822 0 0 0 PF15266; Q96RW7 CHOYP_BRAFLDRAFT_147130.1.2 m.27732 sp HMCN1_HUMAN 34.545 220 135 6 3 218 5119 5333 3.58E-32 126 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99J62 CHOYP_BRAFLDRAFT_284971.1.1 m.8607 sp RFC4_MOUSE 66.667 345 114 1 14 358 17 360 3.58E-167 473 RFC4_MOUSE reviewed Replication factor C subunit 4 (Activator 1 subunit 4) Rfc4 Mus musculus (Mouse) 364 DNA-dependent DNA replication [GO:0006261]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] GO:0003677; GO:0005524; GO:0005634; GO:0005663; GO:0006261; GO:0019899; GO:0031390; GO:1900264 0 0 0 PF00004;PF08542; Q9GNE2 CHOYP_RPL23.2.3 m.43868 sp RL23_AEDAE 89.691 97 10 0 1 97 1 97 3.58E-57 176 RL23_AEDAE reviewed 60S ribosomal protein L23 (AeRpL17A) (L17A) RpL23-A RpL17A AAEL013097; RpL23-B AAEL013583; RpL23-C AAEL015006 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 140 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00238; Q9NR16 CHOYP_SRCR12.1.1 m.53668 sp C163B_HUMAN 28.692 1307 821 42 202 1429 51 1325 3.58E-111 393 C163B_HUMAN reviewed Scavenger receptor cysteine-rich type 1 protein M160 (CD163 antigen-like 1) (CD antigen CD163b) CD163L1 CD163B M160 UNQ6434/PRO23202 Homo sapiens (Human) 1453 mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005044; GO:0005576; GO:0005886; GO:0016021; GO:0098779; GO:0098792 0 0 0 PF00530; Q9UFC0 CHOYP_LRWD1.1.1 m.8862 sp LRWD1_HUMAN 28.411 711 411 29 19 714 17 644 3.58E-71 247 LRWD1_HUMAN reviewed Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) LRWD1 CENP-33 ORCA Homo sapiens (Human) 647 chromatin organization [GO:0006325]; covalent chromatin modification [GO:0016569]; DNA replication initiation [GO:0006270]; establishment of protein localization to chromatin [GO:0071169] GO:0000776; GO:0000777; GO:0003682; GO:0005634; GO:0005664; GO:0005721; GO:0005737; GO:0005815; GO:0006270; GO:0006325; GO:0008327; GO:0016569; GO:0031933; GO:0035064; GO:0071169 0 0 0 PF12799; Q9VUL9 CHOYP_TRIADDRAFT_51654.1.1 m.7330 sp FUCTA_DROME 31.092 238 149 8 98 328 210 439 3.58E-26 112 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; A0A0R4IBK5 CHOYP_BRAFLDRAFT_106560.14.14 m.64823 sp R213A_DANRE 31.047 1137 649 37 416 1467 2402 3488 3.59E-123 442 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A4D0V7 CHOYP_CPED1.1.1 m.17077 sp CPED1_HUMAN 29.449 781 467 16 265 991 270 1020 3.59E-97 333 CPED1_HUMAN reviewed Cadherin-like and PC-esterase domain-containing protein 1 CPED1 C7orf58 UNQ9432/PRO34713 Homo sapiens (Human) 1026 0 GO:0005783 0 0 0 PF12733; B3EWY9 CHOYP_LOC577184.1.1 m.62005 sp MLP_ACRMI 26.565 1310 750 48 92 1305 170 1363 3.59E-93 340 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B3EWZ3 CHOYP_BRAFLDRAFT_88566.6.11 m.28034 sp CADN_ACRMI 43.704 405 218 3 366 762 159 561 3.59E-101 348 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; C8YR32 CHOYP_LOC752556.1.1 m.56645 sp LOXH1_MOUSE 39.344 122 65 2 4 125 174 286 3.59E-22 94 LOXH1_MOUSE reviewed Lipoxygenase homology domain-containing protein 1 Loxhd1 Mus musculus (Mouse) 2068 detection of mechanical stimulus [GO:0050982]; sensory perception of sound [GO:0007605] GO:0005262; GO:0007605; GO:0016020; GO:0032420; GO:0050982 0 0 0 PF01477; O00566 CHOYP_LOC101169524.1.1 m.4630 sp MPP10_HUMAN 39.281 695 361 13 16 696 11 658 3.59E-120 378 MPP10_HUMAN reviewed U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) MPHOSPH10 MPP10 Homo sapiens (Human) 681 "maturation of SSU-rRNA [GO:0030490]; negative regulation of phosphatase activity [GO:0010923]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; rRNA processing [GO:0006364]" GO:0000375; GO:0005654; GO:0005694; GO:0005730; GO:0005732; GO:0006364; GO:0006396; GO:0008380; GO:0010923; GO:0030490; GO:0032040; GO:0034457; GO:0044822 0 0 0 PF04006; P18746 CHOYP_LOC100163693.2.2 m.16379 sp ZO26_XENLA 37.5 72 43 1 544 615 84 153 3.59E-08 57.4 ZO26_XENLA reviewed Oocyte zinc finger protein XlCOF26 (Fragment) 0 Xenopus laevis (African clawed frog) 196 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; P27080 CHOYP_LOC100633390.3.5 m.22820 sp ADT_CHLRE 63.366 303 109 2 1 301 1 303 3.59E-134 385 ADT_CHLRE reviewed "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" ABT Chlamydomonas reinhardtii (Chlamydomonas smithii) 308 transmembrane transport [GO:0055085] GO:0005215; GO:0005743; GO:0016021; GO:0055085 0 0 0 PF00153; P49013 CHOYP_LOC100640260.1.2 m.21931 sp FBP3_STRPU 32.903 465 250 20 5 454 23 440 3.59E-44 169 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P56695 CHOYP_WFS1.1.1 m.25462 sp WFS1_MOUSE 27.995 768 493 12 22 741 94 849 3.59E-95 319 WFS1_MOUSE reviewed Wolframin Wfs1 Mus musculus (Mouse) 890 calcium ion homeostasis [GO:0055074]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; glucose homeostasis [GO:0042593]; kidney development [GO:0001822]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; neurological system process [GO:0050877]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of growth [GO:0045927]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0000122; GO:0000502; GO:0001822; GO:0003091; GO:0005783; GO:0007601; GO:0007605; GO:0030176; GO:0030425; GO:0030433; GO:0030968; GO:0031398; GO:0031625; GO:0032469; GO:0034976; GO:0042593; GO:0043069; GO:0043433; GO:0043524; GO:0045762; GO:0045927; GO:0050821; GO:0050877; GO:0051117; GO:0051247; GO:0051726; GO:0051928; GO:0055074; GO:1902236; GO:1903892; GO:2000675 0 0 0 0 Q02337 CHOYP_RDH7.2.2 m.30103 sp BDH_BOVIN 44.291 289 156 3 9 294 30 316 3.59E-72 230 BDH_BOVIN reviewed "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH)" BDH1 BDH Bos taurus (Bovine) 344 0 GO:0003858; GO:0005654; GO:0005759; GO:0099617 0 0 0 PF00106; Q08094 CHOYP_SMP_078690.1.5 m.1276 sp CNN2_PIG 34.259 216 121 6 4 212 51 252 3.59E-19 87 CNN2_PIG reviewed "Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin) (Fragment)" CNN2 Sus scrofa (Pig) 296 actomyosin structure organization [GO:0031032] GO:0005856; GO:0031032 0 0 0 PF00402;PF00307; Q23023 CHOYP_LOC100875346.1.1 m.28182 sp UNC51_CAEEL 63.664 333 100 3 1 313 1 332 3.59E-128 409 UNC51_CAEEL reviewed Serine/threonine-protein kinase unc-51 (EC 2.7.11.1) (Uncoordinated protein 51) unc-51 Y60A3A.1 Caenorhabditis elegans 856 apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell migration [GO:0016477]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; nematode male tail tip morphogenesis [GO:0045138]; programmed cell death [GO:0012501]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon extension [GO:0030516]; regulation of cell size [GO:0008361]; regulation of multicellular organism growth [GO:0040014]; regulation of protein localization [GO:0032880] GO:0004672; GO:0004674; GO:0005524; GO:0006468; GO:0006914; GO:0007409; GO:0007411; GO:0008340; GO:0008361; GO:0009792; GO:0012501; GO:0016477; GO:0030424; GO:0030516; GO:0032880; GO:0040014; GO:0040024; GO:0043005; GO:0043025; GO:0043277; GO:0045138; GO:0046777; GO:0046872 0 0 0 PF12063;PF00069; Q2QI47 CHOYP_USH2A.6.6 m.63661 sp USH2A_MOUSE 21.268 710 409 27 47 694 4119 4740 3.59E-12 74.3 USH2A_MOUSE reviewed Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) 5193 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042803; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF00054;PF02210;PF00055; Q3T0Q3 CHOYP_RPB3.1.1 m.45705 sp RPB3_BOVIN 73.358 274 72 1 1 273 1 274 3.59E-160 449 RPB3_BOVIN reviewed DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II subunit C) POLR2C Bos taurus (Bovine) 275 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0005665; GO:0005737; GO:0006366; GO:0015630 0 0 0 PF01000;PF01193; Q4PM12 CHOYP_CEG1A.2.6 m.3126 sp RL36_IXOSC 61.176 85 31 1 1 85 1 83 3.59E-32 112 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q5BIM1 CHOYP_LOC100213744.1.19 m.664 sp TRI45_BOVIN 25.743 202 119 10 4 180 127 322 3.59E-07 53.1 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5R662 CHOYP_LRP12.1.2 m.30870 sp LRP12_PONAB 29.612 206 116 10 14 207 16 204 3.59E-12 69.7 LRP12_PONAB reviewed Low-density lipoprotein receptor-related protein 12 (LRP-12) LRP12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 859 endocytosis [GO:0006897] GO:0005887; GO:0005905; GO:0006897 0 0 0 PF00431;PF00057; Q5ZJX5 CHOYP_K1609.1.1 m.17775 sp TLDC1_CHICK 39.036 415 227 7 60 459 62 465 3.59E-91 288 TLDC1_CHICK reviewed TLD domain-containing protein 1 (TBC/LysM-associated domain-containing protein 1) TLDC1 RCJMB04_14k7 Gallus gallus (Chicken) 468 0 0 0 0 0 PF07534; Q6IE24 CHOYP_LOC100186936.1.2 m.12235 sp UBP54_RAT 57.27 337 140 3 38 373 30 363 3.59E-125 433 UBP54_RAT reviewed Inactive ubiquitin carboxyl-terminal hydrolase 54 (Inactive ubiquitin-specific peptidase 54) Usp54 Rattus norvegicus (Rat) 1588 protein deubiquitination [GO:0016579] GO:0016579; GO:0036459 0 0 0 PF00443; Q8CI17 CHOYP_LOC100734486.1.1 m.58321 sp MB213_MOUSE 27.778 162 100 6 243 397 263 414 3.59E-10 64.7 MB213_MOUSE reviewed Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) 429 0 0 0 0 0 PF03281; Q8ISP0 CHOYP_RS18.10.11 m.50687 sp RS18_BRABE 88.542 96 11 0 1 96 57 152 3.59E-62 189 RS18_BRABE reviewed 40S ribosomal protein S18 RPS18 Branchiostoma belcheri (Amphioxus) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q9BXJ4 CHOYP_CAPR2.1.4 m.2474 sp C1QT3_HUMAN 35.593 118 73 2 154 270 110 225 3.59E-13 71.2 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9CWZ7 CHOYP_BRAFLDRAFT_285193.1.1 m.63396 sp SNAG_MOUSE 43.116 276 156 1 48 322 4 279 3.59E-72 229 SNAG_MOUSE reviewed Gamma-soluble NSF attachment protein (SNAP-gamma) (N-ethylmaleimide-sensitive factor attachment protein gamma) Napg Snapg Mus musculus (Mouse) 312 intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; vesicle-mediated transport [GO:0016192] GO:0005483; GO:0005739; GO:0005765; GO:0005774; GO:0006886; GO:0016192; GO:0019905; GO:0031201; GO:0043209; GO:0061025; GO:0070062 0 0 cd15832; 0 Q9H3E2 CHOYP_LOC100375867.1.2 m.23177 sp SNX25_HUMAN 31.429 105 61 2 2 103 473 569 3.59E-10 58.9 SNX25_HUMAN reviewed Sorting nexin-25 SNX25 MSTP043 Homo sapiens (Human) 840 negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein transport [GO:0015031]; receptor catabolic process [GO:0032801] GO:0010008; GO:0015031; GO:0030512; GO:0032801; GO:0035091; GO:0060394 0 0 0 PF08628;PF00787;PF02194;PF00615; Q9JI85 CHOYP_NUCB2.1.2 m.28555 sp NUCB2_RAT 49.709 344 163 3 6 340 12 354 3.59E-98 308 NUCB2_RAT reviewed Nucleobindin-2 (DNA-binding protein NEFA) (Prepronesfatin) [Cleaved into: Nesfatin-1] Nucb2 Nefa Rattus norvegicus (Rat) 420 insulin metabolic process [GO:1901142]; negative regulation of appetite [GO:0032099]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of testosterone secretion [GO:2000845]; response to glucose [GO:0009749]; response to human chorionic gonadotropin [GO:0044752]; response to melanocyte-stimulating hormone [GO:1990680]; response to starvation [GO:0042594] GO:0003677; GO:0005164; GO:0005509; GO:0005615; GO:0005635; GO:0005737; GO:0005783; GO:0005797; GO:0009749; GO:0016020; GO:0030818; GO:0032099; GO:0042594; GO:0044752; GO:0045599; GO:0046321; GO:0046627; GO:0070093; GO:1901142; GO:1990680; GO:2000845 0 0 0 PF13499; Q9JLC8 CHOYP_LOC558150.2.4 m.45847 sp SACS_MOUSE 41.256 223 130 1 15 236 96 318 3.59E-44 164 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; A4IF63 CHOYP_BRAFLDRAFT_205965.12.43 m.23959 sp TRIM2_BOVIN 23.776 143 104 3 38 176 602 743 3.60E-08 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7Y2W8 CHOYP_SC6A5.7.7 m.62985 sp SC6A9_XENLA 42.014 576 311 5 7 571 19 582 3.60E-164 485 SC6A9_XENLA reviewed Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) 633 amino acid transport [GO:0006865] GO:0005283; GO:0005328; GO:0005887; GO:0006865 0 0 0 PF00209; A8Y1P7 CHOYP_BETA4GALNACTA.2.2 m.59391 sp BRE4_CAEBR 43.704 270 148 2 48 313 96 365 3.60E-74 236 BRE4_CAEBR reviewed "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 CBG22165 Caenorhabditis briggsae 384 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0016757; GO:0046872 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9GUM2}. 0 0 PF02709;PF13733; G5ED84 CHOYP_ZBTB24.1.1 m.9868 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 3.60E-11 70.1 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; P08775 CHOYP_PMAR_PMAR024409.3.3 m.32013 sp RPB1_MOUSE 50.427 117 46 2 68 184 1853 1957 3.60E-19 97.4 RPB1_MOUSE reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) Polr2a Rpii215 Rpo2-1 Mus musculus (Mouse) 1970 "cellular response to oxygen levels [GO:0071453]; DNA-templated transcription, termination [GO:0006353]; piRNA metabolic process [GO:0034587]; positive regulation of RNA splicing [GO:0033120]; response to organic cyclic compound [GO:0014070]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0001047; GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0005719; GO:0006353; GO:0006366; GO:0014070; GO:0031625; GO:0033120; GO:0034587; GO:0044822; GO:0046872; GO:0071453 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; P36544 CHOYP_ACHB.3.3 m.13942 sp ACHA7_HUMAN 27.157 313 222 5 15 326 13 320 3.60E-34 135 ACHA7_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 NACHRA7 Homo sapiens (Human) 502 "activation of MAPK activity [GO:0000187]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; cognition [GO:0050890]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; memory [GO:0007613]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0000187; GO:0001540; GO:0001666; GO:0004889; GO:0005886; GO:0005892; GO:0006811; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0007613; GO:0008284; GO:0015276; GO:0015464; GO:0015643; GO:0016021; GO:0017081; GO:0022848; GO:0030054; GO:0032720; GO:0034220; GO:0035094; GO:0042166; GO:0042803; GO:0045211; GO:0045766; GO:0050890 0 0 0 PF02931;PF02932; P37397 CHOYP_PHUM_PHUM289860.1.1 m.44779 sp CNN3_RAT 35.811 296 172 8 9 301 11 291 3.60E-38 143 CNN3_RAT reviewed "Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform)" Cnn3 Rattus norvegicus (Rat) 330 actomyosin structure organization [GO:0031032]; epithelial cell differentiation [GO:0030855]; negative regulation of ATPase activity [GO:0032780] GO:0005737; GO:0005874; GO:0005884; GO:0005925; GO:0008017; GO:0014069; GO:0030425; GO:0030674; GO:0030855; GO:0031032; GO:0032780; GO:0043025; GO:0043197 0 0 0 PF00402;PF00307; P43006 CHOYP_EAA2.3.3 m.45342 sp EAA2_MOUSE 34.205 497 289 6 20 493 39 520 3.60E-88 284 EAA2_MOUSE reviewed Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) Slc1a2 Eaat2 Glt1 Mus musculus (Mouse) 572 adult behavior [GO:0030534]; anion transmembrane transport [GO:0098656]; cellular response to extracellular stimulus [GO:0031668]; D-aspartate import [GO:0070779]; L-glutamate import [GO:0051938]; L-glutamate transmembrane transport [GO:0089711]; L-glutamate transport [GO:0015813]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; nervous system development [GO:0007399]; positive regulation of glucose import [GO:0046326]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to light stimulus [GO:0009416]; response to wounding [GO:0009611]; telencephalon development [GO:0021537]; visual behavior [GO:0007632] GO:0005313; GO:0005886; GO:0005887; GO:0007399; GO:0007632; GO:0008509; GO:0009416; GO:0009611; GO:0009986; GO:0010259; GO:0015501; GO:0015813; GO:0021537; GO:0030424; GO:0030534; GO:0030673; GO:0031668; GO:0035264; GO:0042493; GO:0043200; GO:0046326; GO:0051938; GO:0070779; GO:0089711; GO:0098656 0 0 0 PF00375; P91929 CHOYP_AAEL_AAEL012950.1.1 m.1373 sp NDUAA_DROME 30.887 327 215 5 19 340 24 344 3.60E-44 161 NDUAA_DROME reviewed "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit)" ND-42 CG6343 Drosophila melanogaster (Fruit fly) 407 regulation of glucose metabolic process [GO:0010906] GO:0005739; GO:0005759; GO:0005811; GO:0008137; GO:0010906; GO:0070469 0 0 0 PF01712; Q1EGL2 CHOYP_SLIK4.1.1 m.29502 sp LGI1_PANTR 43.617 94 52 1 202 295 120 212 3.60E-15 80.5 LGI1_PANTR reviewed Leucine-rich glioma-inactivated protein 1 LGI1 Pan troglodytes (Chimpanzee) 557 axon guidance [GO:0007411]; positive regulation of cell growth [GO:0030307]; positive regulation of synaptic transmission [GO:0050806] GO:0005615; GO:0007411; GO:0030054; GO:0030307; GO:0045202; GO:0050806 0 0 0 PF03736;PF13855; Q27546 CHOYP_LOC101157039.2.2 m.54697 sp IUNH_CRIFA 33.226 310 199 7 4 311 3 306 3.60E-43 153 IUNH_CRIFA reviewed Inosine-uridine preferring nucleoside hydrolase (IU-NH) (IU-nucleoside hydrolase) (EC 3.2.2.-) (Non-specific nucleoside hydrolase) (Purine nucleosidase) IUNH Crithidia fasciculata 315 nucleotide metabolic process [GO:0009117] GO:0009117; GO:0016799; GO:0046872 PATHWAY: Purine metabolism; purine nucleoside salvage. 0 0 PF01156; Q2PYN8 CHOYP_LBX1.1.1 m.44098 sp LBX1_XENLA 41.438 292 130 5 43 323 5 266 3.60E-57 189 LBX1_XENLA reviewed Transcription factor LBX1 (Ladybird homeobox protein homolog 1) lbx1 Xenopus laevis (African clawed frog) 267 "cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; myoblast proliferation [GO:0051450]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0006355; GO:0007517; GO:0030154; GO:0043565; GO:0051450 0 0 0 PF00046; Q55CU8 CHOYP_SMP_158620.1.1 m.12760 sp RSC5_DICDI 27.67 206 139 4 2 200 46 248 3.60E-16 82 RSC5_DICDI reviewed Random slug protein 5 (CRAL-TRIO domain-containing protein 5) rsc5 DDB_G0269182 Dictyostelium discoideum (Slime mold) 364 0 0 0 0 0 PF00650;PF03765; Q6R7H0 CHOYP_Y057.1.1 m.30502 sp Y055_OSHVF 100 139 0 0 1 139 1 139 3.60E-98 281 Y055_OSHVF reviewed Uncharacterized protein ORF55 ORF55 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 139 0 0 0 0 0 0 Q868Z9 CHOYP_PPN.2.4 m.44929 sp PPN_DROME 33.529 683 305 17 609 1171 1490 2143 3.60E-97 354 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q86VV8 CHOYP_MT.10.18 m.44062 sp RTTN_HUMAN 36.364 99 53 2 143 233 315 411 3.60E-08 57.4 RTTN_HUMAN reviewed Rotatin RTTN Homo sapiens (Human) 2226 cilium organization [GO:0044782]; determination of left/right symmetry [GO:0007368] GO:0005737; GO:0005813; GO:0007368; GO:0036064; GO:0044782 0 0 0 PF14726; Q8K2R5 CHOYP_ZN184.3.4 m.46428 sp ZN668_MOUSE 25.558 403 227 15 382 735 1 379 3.60E-21 102 ZN668_MOUSE reviewed Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q8STF0 CHOYP_CALM.11.50 m.28106 sp CALM_STRIE 88.742 151 17 0 8 158 6 156 3.60E-95 275 CALM_STRIE reviewed Calmodulin (CaM) 0 Strongylocentrotus intermedius (Sea urchin) 156 0 GO:0005509 0 0 0 PF13499; Q8W469 CHOYP_BRAFLDRAFT_91695.1.1 m.31423 sp SIPL2_ARATH 32.692 104 65 3 266 368 82 181 3.60E-06 53.9 SIPL2_ARATH reviewed Signal peptide peptidase-like 2 (AtSPPL2) (EC 3.4.23.-) SPPL2 At1g63690 F24D7.12 Arabidopsis thaliana (Mouse-ear cress) 540 membrane protein proteolysis [GO:0033619]; signal peptide processing [GO:0006465] GO:0005765; GO:0005768; GO:0006465; GO:0010008; GO:0030660; GO:0033619; GO:0042500; GO:0071458; GO:0071556 0 0 0 PF02225;PF04258; Q91147 CHOYP_LOC100376764.1.1 m.5433 sp FGFR2_NOTVI 41.853 313 168 4 63 374 381 680 3.60E-77 265 FGFR2_NOTVI reviewed Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) FGFR2 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) 729 apoptotic process [GO:0006915]; positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0005794; GO:0005886; GO:0006915; GO:0008284; GO:0016021; GO:0016023 0 0 0 PF07679;PF07714; Q921Y2 CHOYP_LOC100371776.1.3 m.1298 sp IMP3_MOUSE 71.134 97 28 0 1 97 86 182 3.60E-48 154 IMP3_MOUSE reviewed U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) Imp3 Mus musculus (Mouse) 184 rRNA processing [GO:0006364] GO:0005634; GO:0005730; GO:0006364; GO:0030515; GO:0030519; GO:0032040; GO:0034457; GO:0044822 0 0 0 PF00163;PF01479; Q9BXJ4 CHOYP_contig_040100 m.45395 sp C1QT3_HUMAN 31.69 142 85 5 46 180 92 228 3.60E-07 52 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9ESN6 CHOYP_BRAFLDRAFT_232970.4.5 m.35256 sp TRIM2_MOUSE 23.636 275 170 11 925 1180 491 744 3.60E-06 55.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM2.39.59 m.42420 sp TRIM2_MOUSE 28.311 219 135 9 198 406 536 742 3.60E-12 71.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y2G4 CHOYP_LOC408390.1.1 m.25936 sp ANKR6_HUMAN 49.068 161 77 1 1 161 113 268 3.60E-47 169 ANKR6_HUMAN reviewed Ankyrin repeat domain-containing protein 6 (Diversin) ANKRD6 KIAA0957 Homo sapiens (Human) 727 "negative regulation of canonical Wnt signaling pathway [GO:0090090]; positive regulation of JNK cascade [GO:0046330]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]" GO:0005634; GO:0005737; GO:0043231; GO:0046330; GO:0090090; GO:2000096 0 0 0 PF12796; A4IF63 CHOYP_BRAFLDRAFT_241726.2.22 m.3213 sp TRIM2_BOVIN 24.342 152 111 3 139 287 593 743 3.61E-06 52.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NNX1 CHOYP_LOC100369985.1.1 m.35628 sp RIAD1_HUMAN 55.556 72 32 0 38 109 14 85 3.61E-23 89 RIAD1_HUMAN reviewed RIIa domain-containing protein 1 RIIAD1 C1orf230 Homo sapiens (Human) 92 0 0 0 0 0 PF02197; B2RPY5 CHOYP_LOC100704685.1.1 m.5468 sp GP161_MOUSE 27.9 319 214 5 1 306 36 351 3.61E-35 142 GP161_MOUSE reviewed G-protein coupled receptor 161 Gpr161 Gm208 Mus musculus (Mouse) 545 G-protein coupled receptor signaling pathway [GO:0007186]; multicellular organism development [GO:0007275]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; positive regulation of cAMP biosynthetic process [GO:0030819] GO:0004930; GO:0007186; GO:0007275; GO:0016021; GO:0030819; GO:0055037; GO:0060170; GO:0072372; GO:1901621 0 0 0 PF00001; O75319 CHOYP_LOC100179134.1.1 m.23870 sp DUS11_HUMAN 43.529 170 95 1 12 181 32 200 3.61E-48 171 DUS11_HUMAN reviewed RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Dual specificity protein phosphatase 11) (Phosphatase that interacts with RNA/RNP complex 1) DUSP11 PIR1 Homo sapiens (Human) 330 polynucleotide 5' dephosphorylation [GO:0098507]; protein dephosphorylation [GO:0006470]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396] GO:0003723; GO:0004651; GO:0004725; GO:0005634; GO:0006396; GO:0006470; GO:0008138; GO:0016070; GO:0016607; GO:0016791; GO:0044822; GO:0098507; GO:0098519 0 0 0 PF00782; O95453 CHOYP_PCDH9.5.5 m.59488 sp PARN_HUMAN 44.665 403 215 3 2 404 147 541 3.61E-123 374 PARN_HUMAN reviewed Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) PARN DAN Homo sapiens (Human) 639 "female gamete generation [GO:0007292]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of mRNA stability [GO:0043488]; RNA modification [GO:0009451]" GO:0000166; GO:0000184; GO:0000289; GO:0003730; GO:0004518; GO:0004535; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0007292; GO:0009451; GO:0019901; GO:0043488; GO:0044822; GO:0046872 0 0 0 PF04857;PF01424;PF08675; P10079 CHOYP_BRAFLDRAFT_101341.1.1 m.34474 sp FBP1_STRPU 54.701 117 53 0 401 517 403 519 3.61E-33 140 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P34545 CHOYP_LOC100366719.1.1 m.39128 sp CBP1_CAEEL 40 270 78 6 105 290 401 670 3.61E-42 159 CBP1_CAEEL reviewed Protein cbp-1 (EC 2.3.1.48) cbp-1 R10E11.1 Caenorhabditis elegans 2017 "apoptotic process [GO:0006915]; embryo development ending in birth or egg hatching [GO:0009792]; histone acetylation [GO:0016573]; internal peptidyl-lysine acetylation [GO:0018393]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of neuron projection development [GO:0010975]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003712; GO:0004402; GO:0004468; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006915; GO:0007283; GO:0008134; GO:0008270; GO:0009792; GO:0010975; GO:0016573; GO:0018393; GO:0043065; GO:0045944; GO:0061629; GO:0061733 0 0 cd15802; PF00439;PF06001;PF08214;PF02172;PF02135;PF00569; P35859 CHOYP_LOC101074965.1.1 m.48406 sp ALS_RAT 27.411 197 107 11 17 204 214 383 3.61E-06 51.2 ALS_RAT reviewed Insulin-like growth factor-binding protein complex acid labile subunit (ALS) Igfals Als Rattus norvegicus (Rat) 603 aging [GO:0007568]; cell adhesion [GO:0007155]; signal transduction [GO:0007165] GO:0005520; GO:0007155; GO:0007165; GO:0007568; GO:0008022; GO:0042567; GO:0043231 0 0 0 PF13855;PF01462; P49395 CHOYP_RS3A.10.15 m.40676 sp RS3A_APLCA 79.184 245 48 1 31 272 21 265 3.61E-145 410 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P62870 CHOYP_ELOB.1.1 m.56270 sp ELOB_RAT 70.085 117 33 2 1 117 1 115 3.61E-48 152 ELOB_RAT reviewed Transcription elongation factor B polypeptide 2 (Elongin 18 kDa subunit) (Elongin-B) (EloB) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) Tceb2 Rattus norvegicus (Rat) 118 positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ubiquitination [GO:0016567]; transcription elongation from RNA polymerase II promoter [GO:0006368] GO:0003713; GO:0005667; GO:0006368; GO:0016567; GO:0030891; GO:0032403; GO:0045944; GO:0070449 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00240; Q1RML7 CHOYP_contig_020376 m.23584 sp MAK16_BOVIN 44.34 106 54 4 2 102 191 296 3.61E-06 47 MAK16_BOVIN reviewed Protein MAK16 homolog MAK16 Bos taurus (Bovine) 298 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0003676; GO:0005730; GO:0030687; GO:0044822 0 0 0 PF04874;PF01778; Q24K15 CHOYP_FGL2.6.9 m.52529 sp ANGP4_BOVIN 34.892 278 174 4 55 328 221 495 3.61E-52 182 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q32KI9 CHOYP_LOC584392.1.1 m.24512 sp ARSI_MOUSE 40.341 528 244 10 30 537 47 523 3.61E-120 368 ARSI_MOUSE reviewed Arylsulfatase I (ASI) (EC 3.1.6.-) Arsi Mus musculus (Mouse) 573 metabolic process [GO:0008152] GO:0005576; GO:0005783; GO:0008152; GO:0008484; GO:0046872 0 0 0 PF00884; Q32P12 CHOYP_LOC100022903.1.1 m.6458 sp CQ053_MOUSE 38.66 194 107 5 157 342 355 544 3.61E-28 123 CQ053_MOUSE reviewed Uncharacterized protein C17orf53 homolog 0 Mus musculus (Mouse) 615 0 0 0 0 0 PF15072; Q3T042 CHOYP_LOC575793.2.2 m.59219 sp NOB1_BOVIN 43.16 424 185 8 2 418 33 407 3.61E-101 310 NOB1_BOVIN reviewed RNA-binding protein NOB1 NOB1 Bos taurus (Bovine) 413 cleavage involved in rRNA processing [GO:0000469]; maturation of SSU-rRNA [GO:0030490] GO:0000469; GO:0004521; GO:0005634; GO:0030490; GO:0030688; GO:0046872 0 0 0 PF08772;PF17146;PF15017; Q4P9K9 CHOYP_LOC100162079.2.4 m.46809 sp CHS8_USTMA 26.389 360 181 12 288 631 1431 1722 3.61E-23 110 CHS8_USTMA reviewed Chitin synthase 8 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 8) (Myosin chitin synthase 1) CHS8 MCS1 UMAG_03204 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 2005 cell wall organization [GO:0071555] GO:0003677; GO:0003774; GO:0004100; GO:0005524; GO:0005886; GO:0016021; GO:0016459; GO:0030659; GO:0071555 0 0 0 PF00173;PF08766;PF00063; Q4R5M4 CHOYP_YIPF5.1.2 m.25068 sp YIPF5_MACFA 56.031 257 109 2 52 304 1 257 3.61E-93 279 YIPF5_MACFA reviewed Protein YIPF5 (YIP1 family member 5) YIPF5 QccE-13521 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 257 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0015031; GO:0016021; GO:0016192; GO:0030134; GO:0032580 0 0 0 PF04893; Q5DW34 CHOYP_V014.1.1 m.16486 sp EHMT1_MOUSE 28.5 200 128 6 36 233 740 926 3.61E-13 73.6 EHMT1_MOUSE reviewed Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.43) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Lysine N-methyltransferase 1D) Ehmt1 Euhmtase1 Glp Kmt1d Mus musculus (Mouse) 1296 "chromatin modification [GO:0016568]; DNA methylation [GO:0006306]; embryo development [GO:0009790]; histone methylation [GO:0016571]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine dimethylation [GO:0018027]; peptidyl-lysine monomethylation [GO:0018026]; response to fungicide [GO:0060992]" GO:0000122; GO:0002039; GO:0005634; GO:0005654; GO:0005694; GO:0006306; GO:0008168; GO:0008270; GO:0009790; GO:0016279; GO:0016568; GO:0016571; GO:0018024; GO:0018026; GO:0018027; GO:0045892; GO:0046974; GO:0046976; GO:0060992; GO:0070742 0 0 0 PF12796;PF05033;PF00856; Q5EGE1 CHOYP_ISM1.1.1 m.10971 sp ISM1_DANRE 46.091 243 125 4 224 462 214 454 3.61E-68 228 ISM1_DANRE reviewed Isthmin-1 ism1 Danio rerio (Zebrafish) (Brachydanio rerio) 461 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF03782;PF00090; Q5HZV9 CHOYP_PPP1R7.1.1 m.37778 sp PP1R7_RAT 58.842 311 122 1 45 355 55 359 3.61E-119 351 PP1R7_RAT reviewed Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) Ppp1r7 Sds22 Rattus norvegicus (Rat) 360 0 GO:0005634 0 0 0 0 Q6DF94 CHOYP_BRAFLDRAFT_129034.1.1 m.17626 sp SPICE_XENLA 34.375 416 236 14 1 387 1 408 3.61E-46 180 SPICE_XENLA reviewed Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) spice1 ccdc52 Xenopus laevis (African clawed frog) 793 cell division [GO:0051301]; mitotic spindle assembly [GO:0090307]; regulation of centriole replication [GO:0046599] GO:0005814; GO:0005819; GO:0046599; GO:0051301; GO:0090307 0 0 0 PF15678; Q6NY77 CHOYP_LOC579934.1.1 m.59523 sp HOGA1_DANRE 55.627 311 138 0 28 338 14 324 3.61E-129 375 HOGA1_DANRE reviewed "4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase-like) (DHDPS-like protein) (Probable 2-keto-4-hydroxyglutarate aldolase) (Probable KHG-aldolase)" zgc:77082 Danio rerio (Zebrafish) (Brachydanio rerio) 324 glyoxylate catabolic process [GO:0009436] GO:0005739; GO:0008700; GO:0009436 0 0 0 PF00701; Q6P104 CHOYP_BRAFLDRAFT_236368.1.1 m.58422 sp QKIB_DANRE 78.448 116 25 0 1 116 108 223 3.61E-56 186 QKIB_DANRE reviewed Protein quaking-B (Quaking-related protein) qkib qkr zgc:65890 zgc:77340 Danio rerio (Zebrafish) (Brachydanio rerio) 319 cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism development [GO:0007275]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380] GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0006417; GO:0007275; GO:0008380; GO:0030154; GO:0051028 0 0 0 PF00013;PF16544; Q7T3A4 CHOYP_EIN_487230.1.1 m.18698 sp RAB13_DANRE 28.899 218 128 4 21 238 10 200 3.61E-27 106 RAB13_DANRE reviewed Ras-related protein Rab-13 rab13 Danio rerio (Zebrafish) (Brachydanio rerio) 200 angiogenesis [GO:0001525]; bicellular tight junction assembly [GO:0070830]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endothelial cell chemotaxis [GO:0035767]; establishment of protein localization to plasma membrane [GO:0090002]; neuron projection development [GO:0031175]; protein kinase A signaling [GO:0010737]; protein localization to cell leading edge [GO:1902463]; protein secretion [GO:0009306]; small GTPase mediated signal transduction [GO:0007264]; trans-Golgi network to recycling endosome transport [GO:0044795]; vesicle docking involved in exocytosis [GO:0006904] GO:0001525; GO:0005525; GO:0005802; GO:0005886; GO:0005923; GO:0006904; GO:0007264; GO:0009306; GO:0010737; GO:0016328; GO:0030027; GO:0030139; GO:0030659; GO:0030866; GO:0031175; GO:0031410; GO:0032456; GO:0032593; GO:0032869; GO:0035767; GO:0043005; GO:0044795; GO:0055037; GO:0055038; GO:0070830; GO:0090002; GO:1902463 0 0 0 PF00071; Q8N957 CHOYP_LOC100093407.1.1 m.40230 sp ANKF1_HUMAN 46.512 172 82 3 7 178 203 364 3.61E-43 155 ANKF1_HUMAN reviewed Ankyrin repeat and fibronectin type-III domain-containing protein 1 ANKFN1 Homo sapiens (Human) 763 0 0 0 0 0 PF00041; Q8NFP4 CHOYP_LOC100372616.3.3 m.28791 sp MDGA1_HUMAN 31.361 169 101 5 183 341 753 916 3.61E-17 86.3 MDGA1_HUMAN reviewed MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (GPI and MAM protein) (GPIM) (Glycosylphosphatidylinositol-MAM) (MAM domain-containing protein 3) MDGA1 MAMDC3 Homo sapiens (Human) 955 brain development [GO:0007420]; neuron migration [GO:0001764]; spinal cord association neuron differentiation [GO:0021527] GO:0001764; GO:0005615; GO:0005794; GO:0005886; GO:0007420; GO:0021527; GO:0046658 0 0 cd06263; PF00629; Q8NHV1 CHOYP_ZGC_113625.1.2 m.2855 sp GIMA7_HUMAN 38.496 226 135 2 31 254 9 232 3.61E-52 177 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8WZ42 CHOYP_LOC100707926.2.4 m.43941 sp TITIN_HUMAN 24.138 290 190 11 60 329 31475 31754 3.61E-06 53.5 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q91Y44 CHOYP_BRD4.1.1 m.55245 sp BRDT_MOUSE 40.76 763 301 18 73 807 25 664 3.61E-149 477 BRDT_MOUSE reviewed Bromodomain testis-specific protein (Bromodomain-containing female sterile homeotic-like protein) (RING3-like protein) Brdt Fsrg3 Mus musculus (Mouse) 956 "cell differentiation [GO:0030154]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; histone displacement [GO:0001207]; male meiosis [GO:0007140]; male meiosis I [GO:0007141]; mRNA processing [GO:0006397]; positive regulation of transcription involved in meiotic cell cycle [GO:0051039]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0001207; GO:0005634; GO:0006338; GO:0006351; GO:0006397; GO:0007140; GO:0007141; GO:0007283; GO:0008380; GO:0016569; GO:0030154; GO:0042393; GO:0043484; GO:0051039; GO:0070577 0 0 0 PF17035;PF17105;PF00439; Q93075 CHOYP_NEMVEDRAFT_V1G82668.1.1 m.8090 sp TATD2_HUMAN 42.537 268 153 1 1532 1799 495 761 3.61E-74 268 TATD2_HUMAN reviewed Putative deoxyribonuclease TATDN2 (EC 3.1.21.-) TATDN2 KIAA0218 Homo sapiens (Human) 761 DNA catabolic process [GO:0006308]; IRE1-mediated unfolded protein response [GO:0036498] GO:0004536; GO:0005634; GO:0005654; GO:0005737; GO:0006308; GO:0016888; GO:0036498; GO:0046872 0 0 0 PF01026; Q96MM6 CHOYP_BRAFLDRAFT_208293.3.20 m.24910 sp HS12B_HUMAN 33.591 646 347 16 15 598 59 684 3.61E-110 349 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99081 CHOYP_HTF4.4.5 m.55314 sp HTF4_HUMAN 43.284 469 188 20 262 683 220 657 3.61E-74 258 HTF4_HUMAN reviewed Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) TCF12 BHLHB20 HEB HTF4 Homo sapiens (Human) 682 immune response [GO:0006955]; muscle organ development [GO:0007517]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000790; GO:0000978; GO:0001077; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0006955; GO:0007517; GO:0008134; GO:0035326; GO:0035497; GO:0042803; GO:0043425; GO:0045666; GO:0045944; GO:0046332; GO:0046982; GO:0070888; GO:0090575 0 0 0 PF00010; Q9ESN6 CHOYP_BRAFLDRAFT_88223.6.22 m.27911 sp TRIM2_MOUSE 28.241 216 141 7 197 405 535 743 3.61E-09 62.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G247395.3.8 m.14487 sp SACS_HUMAN 23.831 1561 1006 53 11 1486 2696 4158 3.61E-81 300 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9V0D5 CHOYP_CRE_02254.1.1 m.12455 sp MDH_PYRAB 39.503 362 193 9 9 357 14 362 3.61E-73 234 MDH_PYRAB reviewed Malate dehydrogenase (EC 1.1.1.37) mdh PYRAB08550 PAB1791 Pyrococcus abyssi (strain GE5 / Orsay) 362 tricarboxylic acid cycle [GO:0006099] GO:0005737; GO:0006099; GO:0030060 0 0 0 PF02615; Q9WVF8 CHOYP_LOC101077056.1.1 m.1066 sp TUSC2_MOUSE 50.649 77 34 1 40 112 34 110 3.61E-20 81.6 TUSC2_MOUSE reviewed Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2) Tusc2 Fus1 Lgcc Pdap2 Mus musculus (Mouse) 110 cell maturation [GO:0048469]; chemokine (C-C motif) ligand 5 production [GO:0071609]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; interleukin-15 production [GO:0032618]; natural killer cell differentiation [GO:0001779]; negative regulation of interleukin-17 production [GO:0032700]; neutrophil mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of interleukin-10 production [GO:0032733]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to defense-related host reactive oxygen species production [GO:0052567] GO:0001779; GO:0005739; GO:0006909; GO:0006954; GO:0032618; GO:0032700; GO:0032733; GO:0048469; GO:0050829; GO:0051881; GO:0052567; GO:0070945; GO:0071609; GO:2000377 0 0 0 PF15000; D3YXG0 CHOYP_BRAFLDRAFT_85664.1.10 m.4999 sp HMCN1_MOUSE 34.795 365 184 17 29 365 4531 4869 3.62E-36 145 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O73689 CHOYP_ZIC1.1.2 m.7276 sp ZIC1_XENLA 57.188 313 114 7 41 347 82 380 3.62E-117 353 ZIC1_XENLA reviewed Zinc finger protein ZIC 1 (XZic1) (XlZic1) (ODD-paired-like) (Xopl) (ZIC-related protein 1) (ZIC-r1) (Zinc finger protein of the cerebellum 1) zic1 opl Xenopus laevis (African clawed frog) 443 "dorsal/ventral neural tube patterning [GO:0021904]; neural crest cell differentiation [GO:0014033]; neural crest cell fate commitment [GO:0014034]; neural crest formation [GO:0014029]; neural plate development [GO:0001840]; neurogenesis [GO:0022008]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0001840; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0014029; GO:0014033; GO:0014034; GO:0016055; GO:0021904; GO:0022008; GO:0030177; GO:0042307; GO:0045893; GO:0045944; GO:0046872 0 0 0 PF00096; O88281 CHOYP_LOC100376308.1.1 m.60595 sp MEGF6_RAT 29.063 1163 498 59 219 1208 545 1553 3.62E-57 224 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P42674 CHOYP_NAS13.1.1 m.30415 sp BP10_PARLI 41.473 258 137 6 53 299 68 322 3.62E-53 191 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; Q10982 CHOYP_LOC101394768.1.1 m.47952 sp FUT2_PIG 29.741 232 147 6 68 293 67 288 3.62E-26 110 FUT2_PIG reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Sus scrofa (Pig) 340 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q23023 CHOYP_DPSE_GA10675.1.1 m.23862 sp UNC51_CAEEL 44.554 101 52 2 1 101 746 842 3.62E-24 99 UNC51_CAEEL reviewed Serine/threonine-protein kinase unc-51 (EC 2.7.11.1) (Uncoordinated protein 51) unc-51 Y60A3A.1 Caenorhabditis elegans 856 apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell migration [GO:0016477]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; nematode male tail tip morphogenesis [GO:0045138]; programmed cell death [GO:0012501]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon extension [GO:0030516]; regulation of cell size [GO:0008361]; regulation of multicellular organism growth [GO:0040014]; regulation of protein localization [GO:0032880] GO:0004672; GO:0004674; GO:0005524; GO:0006468; GO:0006914; GO:0007409; GO:0007411; GO:0008340; GO:0008361; GO:0009792; GO:0012501; GO:0016477; GO:0030424; GO:0030516; GO:0032880; GO:0040014; GO:0040024; GO:0043005; GO:0043025; GO:0043277; GO:0045138; GO:0046777; GO:0046872 0 0 0 PF12063;PF00069; Q503I2 CHOYP_BRAFLDRAFT_234182.1.1 m.32520 sp TRI13_DANRE 20.188 213 155 4 14 226 73 270 3.62E-06 51.6 TRI13_DANRE reviewed Tripartite motif-containing 13 trim13 zgc:110578 Danio rerio (Zebrafish) (Brachydanio rerio) 404 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q55E58 CHOYP_NEMVEDRAFT_V1G199564.1.6 m.35544 sp PATS1_DICDI 29.098 244 143 9 225 465 1786 2002 3.62E-16 87.8 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5BIM1 CHOYP_CPIPJ_CPIJ001613.2.3 m.32811 sp TRI45_BOVIN 24.155 207 140 6 20 211 127 331 3.62E-09 61.6 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5BIM1 CHOYP_LOC100700101.1.1 m.14068 sp TRI45_BOVIN 23.37 184 132 2 4 187 191 365 3.62E-07 56.2 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q61830 CHOYP_LOC100699850.2.3 m.4991 sp MRC1_MOUSE 23.627 601 375 29 23 578 362 923 3.62E-25 114 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q6DC39 CHOYP_LOC100707081.1.1 m.51749 sp DESI2_DANRE 63.75 160 58 0 1 160 1 160 3.62E-82 244 DESI2_DANRE reviewed Desumoylating isopeptidase 2 (DeSI-2) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 1) (Protein FAM152A) desi2 fam152a pppde1 si:ch211-132e22.3 zgc:100860 Danio rerio (Zebrafish) (Brachydanio rerio) 196 convergent extension involved in gastrulation [GO:0060027] GO:0005737; GO:0008233; GO:0060027 0 0 0 PF05903; Q8N2E2 CHOYP_LOC100006681.1.1 m.38085 sp VWDE_HUMAN 28.664 307 203 9 730 1028 809 1107 3.62E-21 104 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8Q0U0 CHOYP_TVAG_388180.8.8 m.66193 sp Y045_METMA 26.115 314 197 9 328 640 48 327 3.62E-18 90.1 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q8WYH8 CHOYP_ING5.1.1 m.11350 sp ING5_HUMAN 63.306 248 77 2 50 292 1 239 3.62E-109 319 ING5_HUMAN reviewed Inhibitor of growth protein 5 (p28ING5) ING5 Homo sapiens (Human) 240 "chromatin modification [GO:0016568]; DNA replication [GO:0006260]; histone H3 acetylation [GO:0043966]; negative regulation of cell proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of transcription, DNA-templated [GO:0045893]; protein acetylation [GO:0006473]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0005634; GO:0005654; GO:0006260; GO:0006351; GO:0006473; GO:0008270; GO:0008285; GO:0016568; GO:0035064; GO:0043065; GO:0043966; GO:0045893; GO:0045926; GO:0070776; GO:1901796; GO:2001235 0 0 0 PF12998; Q92753 CHOYP_RORG.2.2 m.4977 sp RORB_HUMAN 45.263 95 52 0 42 136 16 110 3.62E-21 99.8 RORB_HUMAN reviewed Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) RORB NR1F2 RZRB Homo sapiens (Human) 470 "amacrine cell differentiation [GO:0035881]; brain development [GO:0007420]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; eye photoreceptor cell development [GO:0042462]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; regulation of transcription, DNA-templated [GO:0006355]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; transcription initiation from RNA polymerase II promoter [GO:0006367]; visual perception [GO:0007601]" GO:0003700; GO:0003707; GO:0004879; GO:0005634; GO:0005654; GO:0006355; GO:0006367; GO:0007420; GO:0007601; GO:0007623; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0043565; GO:0045668; GO:0045892; GO:0045893; GO:0046548; GO:0046549; GO:0060041; GO:0071300 0 0 0 PF00104;PF00105; Q92778 CHOYP_LOC101405965.1.1 m.23152 sp PBCG_MESAU 26.061 165 108 7 7 166 13 168 3.62E-08 53.5 PBCG_MESAU reviewed Pancreatic beta cell growth factor (Islet neogenesis-associated protein) INGAP Mesocricetus auratus (Golden hamster) 175 cell growth [GO:0016049]; cell proliferation [GO:0008283] GO:0005576; GO:0008283; GO:0016049; GO:0030246 0 0 0 PF00059; Q99081 CHOYP_HTF4.1.5 m.16262 sp HTF4_HUMAN 38.45 684 293 34 45 639 13 657 3.62E-82 277 HTF4_HUMAN reviewed Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) TCF12 BHLHB20 HEB HTF4 Homo sapiens (Human) 682 immune response [GO:0006955]; muscle organ development [GO:0007517]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000790; GO:0000978; GO:0001077; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0006955; GO:0007517; GO:0008134; GO:0035326; GO:0035497; GO:0042803; GO:0043425; GO:0045666; GO:0045944; GO:0046332; GO:0046982; GO:0070888; GO:0090575 0 0 0 PF00010; Q99M80 CHOYP_PTPRA.15.22 m.52503 sp PTPRT_MOUSE 39.655 232 137 2 344 573 900 1130 3.62E-46 178 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9CZJ2 CHOYP_HS12A.10.33 m.38139 sp HS12B_MOUSE 30.579 242 159 3 13 245 444 685 3.62E-35 135 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9R0W9 CHOYP_LOC100374210.2.2 m.38915 sp ACHA6_MOUSE 32.025 484 294 5 4 462 10 483 3.62E-73 242 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9V5N8 CHOYP_NIDE3135.1.1 m.36897 sp STAN_DROME 26.151 478 289 18 126 564 665 1117 3.62E-22 105 STAN_DROME reviewed Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) 3579 "axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Wnt signaling pathway [GO:0030178]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; positive regulation of Wnt signaling pathway [GO:0030177]; R3/R4 cell fate commitment [GO:0007464]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of establishment of planar polarity [GO:0090175]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" GO:0001736; GO:0001738; GO:0004872; GO:0004888; GO:0004930; GO:0005057; GO:0005509; GO:0005887; GO:0005911; GO:0007156; GO:0007164; GO:0007165; GO:0007367; GO:0007409; GO:0007411; GO:0007464; GO:0016021; GO:0016055; GO:0016318; GO:0016319; GO:0016339; GO:0016358; GO:0019233; GO:0030177; GO:0030178; GO:0035159; GO:0042067; GO:0045746; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:0090175; GO:1902669 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9Y576 CHOYP_ASB1.1.1 m.19598 sp ASB1_HUMAN 30.827 266 156 7 33 275 75 335 3.62E-23 100 ASB1_HUMAN reviewed Ankyrin repeat and SOCS box protein 1 (ASB-1) ASB1 KIAA1146 Homo sapiens (Human) 335 intracellular signal transduction [GO:0035556]; male genitalia development [GO:0030539]; negative regulation of cytokine biosynthetic process [GO:0042036]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0030539; GO:0035556; GO:0042036 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; A0R5M8 CHOYP_LOC100644613.1.1 m.55011 sp EGTD_MYCS2 26.266 316 206 11 10 317 25 321 3.63E-20 92.4 EGTD_MYCS2 reviewed Histidine N-alpha-methyltransferase (EC 2.1.1.44) (Histidine trimethyltransferase) egtD MSMEG_6247 MSMEI_6086 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 321 "ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine [GO:0052704]; N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine [GO:0052707]" GO:0008276; GO:0030745; GO:0052704; GO:0052707 "PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis. {ECO:0000269|PubMed:23629716, ECO:0000305|PubMed:20420449}." 0 0 PF10017; A0R5M8 CHOYP_RPS11.2.5 m.21116 sp EGTD_MYCS2 26.266 316 206 11 10 317 25 321 3.63E-20 92.4 EGTD_MYCS2 reviewed Histidine N-alpha-methyltransferase (EC 2.1.1.44) (Histidine trimethyltransferase) egtD MSMEG_6247 MSMEI_6086 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 321 "ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine [GO:0052704]; N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine [GO:0052707]" GO:0008276; GO:0030745; GO:0052704; GO:0052707 "PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis. {ECO:0000269|PubMed:23629716, ECO:0000305|PubMed:20420449}." 0 0 PF10017; A4IF63 CHOYP_BRAFLDRAFT_87325.10.11 m.32937 sp TRIM2_BOVIN 33.333 105 68 1 28 130 627 731 3.63E-10 60.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5PN52 CHOYP_U722.1.1 m.64492 sp CK088_DANRE 45.669 127 64 2 33 159 20 141 3.63E-24 96.3 CK088_DANRE reviewed UPF0722 protein C11orf88 homolog si:dkey-27p23.3 Danio rerio (Zebrafish) (Brachydanio rerio) 164 skeletal muscle fiber development [GO:0048741] GO:0048741 0 0 0 0 A6QBB6 CHOYP_CHRO_0413.2.2 m.40390 sp SELU_SULNB 37.186 199 111 6 76 268 16 206 3.63E-27 111 SELU_SULNB reviewed tRNA 2-selenouridine synthase (EC 2.9.1.-) (Selenophosphate-dependent tRNA 2-selenouridine synthase) selU SUN_1828 Sulfurovum sp. (strain NBC37-1) 364 tRNA seleno-modification [GO:0070329] GO:0043828; GO:0070329 0 0 0 PF00581; B6RSP1 CHOYP_LOC593558.1.4 m.22005 sp PKHA7_DANRE 38.29 269 126 5 13 251 1 259 3.63E-48 192 PKHA7_DANRE reviewed Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) (Heart adapter protein 1) plekha7 hadp1 Danio rerio (Zebrafish) (Brachydanio rerio) 1197 cardiac muscle cell differentiation [GO:0055007]; epithelial cell-cell adhesion [GO:0090136]; regulation of heart contraction [GO:0008016]; zonula adherens maintenance [GO:0045218] GO:0005737; GO:0005813; GO:0005915; GO:0008016; GO:0045218; GO:0055007; GO:0070097; GO:0090136 0 0 0 PF00169;PF00397; O62763 CHOYP_NEMVEDRAFT_V1G160761.1.1 m.5557 sp ACES_FELCA 28.142 366 227 15 1 355 228 568 3.63E-28 119 ACES_FELCA reviewed Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Felis catus (Cat) (Felis silvestris catus) 611 acetylcholine catabolic process [GO:0006581] GO:0003990; GO:0005615; GO:0005886; GO:0006581; GO:0030054; GO:0031225; GO:0031594 0 0 0 PF08674;PF00135; O70277 CHOYP_LOC100373444.44.79 m.39021 sp TRIM3_RAT 26.207 290 189 13 281 556 465 743 3.63E-14 79.3 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P02466 CHOYP_LOC659206.6.6 m.43541 sp CO1A2_RAT 40.309 1424 613 32 452 1768 79 1372 3.63E-156 518 CO1A2_RAT reviewed Collagen alpha-2(I) chain (Alpha-2 type I collagen) Col1a2 Rattus norvegicus (Rat) 1372 cellular response to organic substance [GO:0071310]; cellular response to retinoic acid [GO:0071300]; cellular response to thyroid hormone stimulus [GO:0097067]; extracellular matrix organization [GO:0030198]; response to norepinephrine [GO:0071873] GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0030198; GO:0046872; GO:0071300; GO:0071310; GO:0071873; GO:0097067 0 0 0 PF01410;PF01391; P18288 CHOYP_LOC584364.2.2 m.57788 sp TBAT_ONCMY 86.413 184 25 0 60 243 1 184 3.63E-104 312 TBAT_ONCMY reviewed "Tubulin alpha chain, testis-specific [Cleaved into: Detyrosinated tubulin alpha chain, testis-specific]" 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P23919 CHOYP_LOC100369259.1.1 m.7509 sp KTHY_HUMAN 53.14 207 94 2 15 218 5 211 3.63E-75 229 KTHY_HUMAN reviewed Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) DTYMK CDC8 TMPK TYMK Homo sapiens (Human) 212 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; myoblast differentiation [GO:0045445]; nucleobase-containing small molecule interconversion [GO:0015949]; response to cadmium ion [GO:0046686]; response to estrogen [GO:0043627] GO:0004798; GO:0005524; GO:0005634; GO:0005739; GO:0005758; GO:0005759; GO:0005829; GO:0006227; GO:0006233; GO:0006235; GO:0007049; GO:0008283; GO:0009041; GO:0015949; GO:0043627; GO:0045445; GO:0046686; GO:0050145; GO:0071363 PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. 0 0 0 P29314 CHOYP_RPS9.1.1 m.50444 sp RS9_RAT 96.907 97 3 0 13 109 85 181 3.63E-63 194 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P57044 CHOYP_AOR_1_1386094.3.6 m.15990 sp ILK_CAVPO 40.741 108 64 0 2 109 24 131 3.63E-21 89.7 ILK_CAVPO reviewed Integrin-linked protein kinase (EC 2.7.11.1) (Beta-integrin-linked kinase) ILK Cavia porcellus (Guinea pig) 451 0 GO:0004674; GO:0005524; GO:0005886; GO:0005925; GO:0030017; GO:0030027 0 0 0 PF12796;PF07714; P82596 CHOYP_FCER2.8.9 m.27227 sp PLC_HALLA 38.525 122 71 4 33 152 12 131 3.63E-21 87.4 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; P83425 CHOYP_LOC100330792.2.2 m.53521 sp HIP_MYTED 29.927 137 79 5 58 186 85 212 3.63E-09 57.4 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q460N5 CHOYP_PARP14.17.22 m.53652 sp PAR14_HUMAN 35.127 353 217 7 299 646 804 1149 3.63E-52 198 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5I4F8 CHOYP_BRAFLDRAFT_117393.1.1 m.38563 sp AQP8_NOTAL 42.308 234 125 5 13 240 27 256 3.63E-53 175 AQP8_NOTAL reviewed Aquaporin-8 (AQP-8) AQP8 Notomys alexis (Spinifex hopping mouse) 261 0 GO:0005215; GO:0016021 0 0 0 PF00230; Q5TAA0 CHOYP_LOC100702306.1.1 m.14743 sp TTC22_HUMAN 27.273 231 133 10 14 220 22 241 3.63E-07 53.5 TTC22_HUMAN reviewed Tetratricopeptide repeat protein 22 (TPR repeat protein 22) TTC22 Homo sapiens (Human) 569 0 0 0 0 0 0 Q63HN8 CHOYP_LOC100030710.3.4 m.18655 sp RN213_HUMAN 27.67 1283 795 48 1 1228 3991 5195 3.63E-107 377 RN213_HUMAN reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) 5207 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:21799892}. 0 0 PF00097; Q69ZZ6 CHOYP_TMCC1.1.1 m.23991 sp TMCC1_MOUSE 43.215 479 216 11 76 518 187 645 3.63E-102 323 TMCC1_MOUSE reviewed Transmembrane and coiled-coil domains protein 1 Tmcc1 Kiaa0779 Mus musculus (Mouse) 649 0 GO:0005789; GO:0016021 0 0 0 PF10267; Q6ZRF8 CHOYP_TIF1B.3.10 m.4002 sp RN207_HUMAN 31.868 91 56 4 16 104 103 189 3.63E-07 50.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7JWG9 CHOYP_LOC100691963.1.1 m.11035 sp RM52_DROME 42.683 82 47 0 41 122 27 108 3.63E-19 80.1 RM52_DROME reviewed "39S ribosomal protein L52, mitochondrial (L52mt) (MRP-L52)" mRpL52 CG1577 Drosophila melanogaster (Fruit fly) 126 translation [GO:0006412] GO:0003735; GO:0005762; GO:0006412 0 0 0 0 Q80YS5 CHOYP_contig_023120 m.26288 sp LRC27_MOUSE 30.283 459 247 17 94 503 72 506 3.63E-33 135 LRC27_MOUSE reviewed Leucine-rich repeat-containing protein 27 Lrrc27 Mus musculus (Mouse) 523 0 0 0 0 0 PF13855; Q8BGV9 CHOYP_ATG4D.1.1 m.62531 sp ATG4D_MOUSE 42.241 464 190 9 190 620 56 474 3.63E-121 370 ATG4D_MOUSE reviewed "Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagin-4) (Autophagy-related cysteine endopeptidase 4) (Autophagy-related protein 4 homolog D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]" Atg4d Apg4d Autl4 Mus musculus (Mouse) 474 apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; C-terminal protein lipidation [GO:0006501]; mitophagy [GO:0000422]; nucleophagy [GO:0044804]; protein delipidation [GO:0051697]; protein processing [GO:0016485]; protein targeting to membrane [GO:0006612] GO:0000045; GO:0000422; GO:0004197; GO:0005737; GO:0005759; GO:0005829; GO:0006501; GO:0006612; GO:0006914; GO:0006915; GO:0016485; GO:0044804; GO:0051697 0 0 0 PF03416; Q8BHN0 CHOYP_LOC101318494.1.1 m.40808 sp PPM1L_MOUSE 28.947 190 113 7 23 196 6 189 3.63E-15 77.4 PPM1L_MOUSE reviewed Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) Ppm1l Kiaa4175 Mus musculus (Mouse) 360 MAPK cascade [GO:0000165]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178] GO:0000165; GO:0004722; GO:0005622; GO:0007178; GO:0016021; GO:0046872; GO:0070062 0 0 0 PF00481; Q8CGF7 CHOYP_BRAFLDRAFT_117283.2.2 m.37545 sp TCRG1_MOUSE 45.038 262 97 5 234 465 434 678 3.63E-48 181 TCRG1_MOUSE reviewed Transcription elongation regulator 1 (Formin-binding protein 28) (FBP 28) (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) (p144) Tcerg1 Taf2s Mus musculus (Mouse) 1100 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001103; GO:0001106; GO:0003700; GO:0005634; GO:0005730; GO:0006351; GO:0015629; GO:0044822; GO:0070064 0 0 0 PF01846;PF00397; Q92982 CHOYP_LOC100123713.2.3 m.39343 sp NINJ1_HUMAN 27.632 76 55 0 170 245 39 114 3.63E-06 49.3 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q9HBM0 CHOYP_VEZT.1.3 m.18553 sp VEZA_HUMAN 28.423 482 288 18 1 449 144 601 3.63E-38 152 VEZA_HUMAN reviewed Vezatin VEZT Homo sapiens (Human) 779 single organismal cell-cell adhesion [GO:0016337] GO:0001669; GO:0005654; GO:0005737; GO:0005886; GO:0005912; GO:0016021; GO:0016337 0 0 0 PF12632; Q9NFP5 CHOYP_SH3L1.1.5 m.1521 sp SH3BG_DROME 45.283 106 50 2 1 99 1 105 3.63E-25 99.8 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9UL25 CHOYP_LOC100115628.1.1 m.54797 sp RAB21_HUMAN 40.758 211 117 1 7 217 21 223 3.63E-56 181 RAB21_HUMAN reviewed Ras-related protein Rab-21 RAB21 KIAA0118 Homo sapiens (Human) 225 anterograde axonal transport [GO:0008089]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein transport [GO:0015031]; regulation of axon extension [GO:0030516]; regulation of exocytosis [GO:0017157]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005768; GO:0005789; GO:0005802; GO:0005925; GO:0007264; GO:0008089; GO:0009898; GO:0012506; GO:0015031; GO:0017157; GO:0019003; GO:0030516; GO:0030659; GO:0032154; GO:0032580; GO:0048260; GO:0050775; GO:0070062; GO:0098559; GO:1904115; GO:2000643 0 0 0 PF00071; Q9VUL9 CHOYP_FUCTA.4.4 m.61598 sp FUCTA_DROME 32.184 348 205 14 45 381 148 475 3.63E-36 141 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q9Y493 CHOYP_NEMVEDRAFT_V1G214844.14.34 m.34708 sp ZAN_HUMAN 33.803 497 297 7 1112 1587 538 1023 3.63E-28 129 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A4IF63 CHOYP_METK1.1.2 m.59871 sp TRIM2_BOVIN 26.761 213 140 6 333 537 540 744 3.64E-12 72.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O46640 CHOYP_LOC100710565.1.1 m.5315 sp ST3A1_RABIT 30.37 270 164 7 77 331 26 286 3.64E-33 127 ST3A1_RABIT reviewed Amine sulfotransferase (EC 2.8.2.3) (AST-RB1) (Sulfotransferase 3A1) (ST3A1) SULT3A1 ST3A1 Oryctolagus cuniculus (Rabbit) 301 0 GO:0005737; GO:0047685 0 0 0 PF00685; O75382 CHOYP_BRAFLDRAFT_87332.1.6 m.3580 sp TRIM3_HUMAN 24.123 228 135 11 170 382 523 727 3.64E-06 52.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O94972 CHOYP_TRI37.1.2 m.17820 sp TRI37_HUMAN 26.636 214 130 6 44 255 94 282 3.64E-08 60.1 TRI37_HUMAN reviewed E3 ubiquitin-protein ligase TRIM37 (EC 6.3.2.-) (Mulibrey nanism protein) (Tripartite motif-containing protein 37) TRIM37 KIAA0898 MUL POB1 Homo sapiens (Human) 964 "aggresome assembly [GO:0070842]; histone H2A-K119 monoubiquitination [GO:0036353]; histone H2A monoubiquitination [GO:0035518]; negative regulation of centriole replication [GO:0046600]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein autoubiquitination [GO:0051865]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003682; GO:0004842; GO:0005164; GO:0005737; GO:0005777; GO:0005829; GO:0006351; GO:0008270; GO:0016235; GO:0016874; GO:0031625; GO:0032088; GO:0035518; GO:0036353; GO:0042803; GO:0046600; GO:0048471; GO:0051091; GO:0051092; GO:0051865; GO:0061630; GO:0070842 "PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:15885686, ECO:0000269|PubMed:25470042}." 0 0 PF00917;PF00643; P16157 CHOYP_LOC583072.14.25 m.52235 sp ANK1_HUMAN 29.484 814 517 25 1225 2020 12 786 3.64E-65 249 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18503 CHOYP_BRAFLDRAFT_76550.10.21 m.50091 sp CAS4_EPHMU 33.607 122 57 5 14 130 207 309 3.64E-07 52.8 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P41436 CHOYP_LOC101166883.1.2 m.22970 sp IAP_GVCPM 23.897 272 171 4 33 270 5 274 3.64E-21 93.2 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P41512 CHOYP_TOP1.3.5 m.56766 sp TOP1_XENLA 42.718 103 59 0 3 105 581 683 3.64E-19 84.3 TOP1_XENLA reviewed DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) top1 Xenopus laevis (African clawed frog) 829 chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA topological change [GO:0006265] GO:0001046; GO:0003917; GO:0003918; GO:0005634; GO:0005694; GO:0006265; GO:0006338; GO:0032922 0 0 0 PF14370;PF01028;PF02919; P41512 CHOYP_TOP1.4.5 m.56815 sp TOP1_XENLA 42.718 103 59 0 3 105 581 683 3.64E-19 84.3 TOP1_XENLA reviewed DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) top1 Xenopus laevis (African clawed frog) 829 chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; DNA topological change [GO:0006265] GO:0001046; GO:0003917; GO:0003918; GO:0005634; GO:0005694; GO:0006265; GO:0006338; GO:0032922 0 0 0 PF14370;PF01028;PF02919; P48416 CHOYP_C49A1.2.2 m.18317 sp CP10_LYMST 25.735 136 78 4 2 131 233 351 3.64E-07 50.8 CP10_LYMST reviewed Cytochrome P450 10 (EC 1.14.-.-) (CYPX) CYP10 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 545 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037 0 0 0 PF00067; P62914 CHOYP_RL11.1.7 m.9299 sp RL11_RAT 84.756 164 25 0 1 164 12 175 3.64E-100 289 RL11_RAT reviewed 60S ribosomal protein L11 Rpl11 Rattus norvegicus (Rat) 178 negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; protein localization to nucleus [GO:0034504]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0019843; GO:0022625; GO:0022626; GO:0034504; GO:0042975; GO:0043433 0 0 0 PF00281;PF00673; Q0IQU1 CHOYP_LOC100206475.16.16 m.60761 sp LAC22_ORYSJ 26.917 587 319 19 153 713 48 550 3.64E-43 167 LAC22_ORYSJ reviewed Laccase-22 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 22) (Diphenol oxidase 22) (Urishiol oxidase 22) LAC22 Os11g0708100 LOC_Os11g48060 OsJ_033548 Oryza sativa subsp. japonica (Rice) 564 lignin biosynthetic process [GO:0009809]; lignin catabolic process [GO:0046274] GO:0005507; GO:0009809; GO:0016722; GO:0046274; GO:0048046; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q20655 CHOYP_LOC710252.1.1 m.7973 sp 14332_CAEEL 63.462 156 42 2 1 156 1 141 3.64E-57 184 14332_CAEEL reviewed 14-3-3-like protein 2 ftt-2 F52D10.3 Caenorhabditis elegans 248 cytoplasmic sequestering of transcription factor [GO:0042994]; dauer larval development [GO:0040024]; negative regulation of protein import into nucleus [GO:0042308] GO:0005634; GO:0005737; GO:0008134; GO:0040024; GO:0042308; GO:0042994 0 0 0 PF00244; Q3ZBD2 CHOYP_LOC100891502.1.1 m.14627 sp ARP10_BOVIN 50.384 391 192 2 1 389 1 391 3.64E-143 416 ARP10_BOVIN reviewed Actin-related protein 10 ACTR10 Bos taurus (Bovine) 417 microtubule-based movement [GO:0007018] GO:0005737; GO:0005869; GO:0007018 0 0 0 PF00022; Q66HY8 CHOYP_AAEL_AAEL010939.1.1 m.64870 sp PDXD1_DANRE 39.873 316 167 9 106 415 368 666 3.64E-58 208 PDXD1_DANRE reviewed Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) pdxdc1 zgc:92179 Danio rerio (Zebrafish) (Brachydanio rerio) 751 carboxylic acid metabolic process [GO:0019752] GO:0016831; GO:0019752; GO:0030170 0 0 0 PF00282; Q6GMR7 CHOYP_FAAH2.1.1 m.14295 sp FAAH2_HUMAN 60.938 128 50 0 1 128 206 333 3.64E-48 165 FAAH2_HUMAN reviewed Fatty-acid amide hydrolase 2 (EC 3.5.1.99) (Amidase domain-containing protein) (Anandamide amidohydrolase 2) (Oleamide hydrolase 2) FAAH2 AMDD Homo sapiens (Human) 532 arachidonic acid metabolic process [GO:0019369] GO:0005811; GO:0016021; GO:0016884; GO:0017064; GO:0019369; GO:0103073 0 0 0 PF01425; Q6P1E7 CHOYP_CCDC111.1.1 m.17557 sp PRIPO_MOUSE 40.952 525 255 10 27 542 2 480 3.64E-121 370 PRIPO_MOUSE reviewed DNA-directed primase/polymerase protein (EC 2.7.7.-) (Coiled-coil domain-containing protein 111) Primpol Ccdc111 Mus musculus (Mouse) 537 mitochondrial DNA replication [GO:0006264]; replication fork processing [GO:0031297]; response to UV [GO:0009411]; translesion synthesis [GO:0019985] GO:0003682; GO:0003887; GO:0003896; GO:0005634; GO:0005759; GO:0006264; GO:0009411; GO:0019985; GO:0031297 0 0 0 0 Q6PFY8 CHOYP_TRI45.7.23 m.21482 sp TRI45_MOUSE 28.571 189 115 5 5 181 127 307 3.64E-12 67 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7M456 CHOYP_LOC100114608.2.2 m.60777 sp RNOY_CRAGI 34.359 195 107 9 26 207 2 188 3.64E-27 107 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q8CI15 CHOYP_LOC100553460.1.1 m.18538 sp SPHK1_MOUSE 53.043 115 54 0 157 271 11 125 3.64E-35 133 SPHK1_MOUSE reviewed Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) Sphk1 Mus musculus (Mouse) 382 blood vessel development [GO:0001568]; brain development [GO:0007420]; calcium-mediated signaling [GO:0019722]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to starvation [GO:0009267]; cyclooxygenase pathway [GO:0019371]; female pregnancy [GO:0007565]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of neuron projection development [GO:0010976]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of smooth muscle contraction [GO:0045987]; regulation of interleukin-1 beta production [GO:0032651]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to amine [GO:0014075]; response to ATP [GO:0033198]; response to interleukin-1 [GO:0070555]; response to magnesium ion [GO:0032026]; response to progesterone [GO:0032570]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670] GO:0000287; GO:0001568; GO:0001956; GO:0003677; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006670; GO:0006954; GO:0007420; GO:0007565; GO:0008021; GO:0008284; GO:0008481; GO:0009267; GO:0010800; GO:0010803; GO:0010976; GO:0014075; GO:0017050; GO:0019371; GO:0019722; GO:0030307; GO:0030335; GO:0030424; GO:0031398; GO:0032026; GO:0032570; GO:0032651; GO:0033198; GO:0038036; GO:0042346; GO:0043066; GO:0045766; GO:0045931; GO:0045987; GO:0046512; GO:0048146; GO:0051092; GO:0051721; GO:0070301; GO:0070555; GO:0071363 0 0 0 PF00781; Q91145 CHOYP_BRAFLDRAFT_240914.1.3 m.27709 sp COCA1_NOTVI 29.358 218 136 4 110 315 599 810 3.64E-20 95.1 COCA1_NOTVI reviewed Collagen alpha-1(XII) chain (Fragment) 0 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) 929 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF00041;PF00092; Q922Y0 CHOYP_BRAFLDRAFT_65825.1.1 m.24692 sp DYRK3_MOUSE 31.127 408 227 13 55 425 187 577 3.64E-43 170 DYRK3_MOUSE reviewed Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1) Dyrk3 Mus musculus (Mouse) 586 erythrocyte differentiation [GO:0030218]; peptidyl-tyrosine phosphorylation [GO:0018108]; protein phosphorylation [GO:0006468] GO:0000287; GO:0004672; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0006468; GO:0018108; GO:0030218 0 0 0 PF00069; Q969H0 CHOYP_LOC584271.1.1 m.6745 sp FBXW7_HUMAN 37.671 438 240 12 255 683 238 651 3.64E-85 285 FBXW7_HUMAN reviewed F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) FBXW7 FBW7 FBX30 SEL10 Homo sapiens (Human) 707 cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; lipid homeostasis [GO:0055088]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of SREBP signaling pathway [GO:2000639]; negative regulation of triglyceride biosynthetic process [GO:0010868]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein polyubiquitination [GO:0000209]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of lipid storage [GO:0010883]; regulation of mitophagy [GO:1903146]; regulation of protein localization [GO:0032880]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062]; vasculature development [GO:0001944]; viral process [GO:0016032] GO:0000209; GO:0001944; GO:0004842; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006974; GO:0007062; GO:0010868; GO:0010883; GO:0016032; GO:0016567; GO:0019005; GO:0030332; GO:0030674; GO:0031146; GO:0031398; GO:0031625; GO:0032876; GO:0032880; GO:0034644; GO:0042802; GO:0043234; GO:0045741; GO:0045746; GO:0050816; GO:0050821; GO:0051443; GO:0055088; GO:0070374; GO:0097027; GO:1901800; GO:1902806; GO:1903146; GO:1903378; GO:1903955; GO:1990452; GO:2000060; GO:2000346; GO:2000639 0 0 0 PF12937;PF00400; Q96NE9 CHOYP_LOC592633.1.1 m.8517 sp FRMD6_HUMAN 37.293 362 209 9 1 349 1 357 3.64E-67 240 FRMD6_HUMAN reviewed FERM domain-containing protein 6 (Willin) FRMD6 C14orf31 Homo sapiens (Human) 622 apical constriction [GO:0003383]; cellular protein localization [GO:0034613]; regulation of actin filament-based process [GO:0032970] GO:0003383; GO:0005737; GO:0005856; GO:0005886; GO:0032970; GO:0034613; GO:0043296 0 0 0 PF09380;PF00373;PF09379; Q99L45 CHOYP_AAEL_AAEL011527.1.1 m.20909 sp IF2B_MOUSE 58.944 341 103 11 23 338 1 329 3.64E-110 327 IF2B_MOUSE reviewed Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) Eif2s2 Mus musculus (Mouse) 331 in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584] GO:0001701; GO:0002176; GO:0003743; GO:0005737; GO:0008584; GO:0044822; GO:0046872 0 0 0 PF01873; Q99P25 CHOYP_BRAFLDRAFT_117631.1.1 m.45793 sp TXIP1_MOUSE 36.309 661 389 9 36 691 33 666 3.64E-134 415 TXIP1_MOUSE reviewed Translin-associated factor X-interacting protein 1 (Trax-interacting protein 1) Tsnaxip1 Txi1 Mus musculus (Mouse) 704 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0007275; GO:0007283; GO:0030154; GO:0048471 0 0 0 PF15739; Q9JKP8 CHOYP_CHRC1.2.2 m.40369 sp CHRC1_MOUSE 56.522 92 38 2 28 117 19 110 3.64E-25 95.1 CHRC1_MOUSE reviewed Chromatin accessibility complex protein 1 (CHRAC-1) (DNA polymerase epsilon subunit p15) (NF-YC-like protein) (YC-like protein 1) (YCL1) Chrac1 Mus musculus (Mouse) 129 chromatin remodeling [GO:0006338] GO:0003677; GO:0003887; GO:0006338; GO:0008623 0 0 0 PF00808; Q9P2E3 CHOYP_ZNFX1.12.12 m.65014 sp ZNFX1_HUMAN 25.617 324 186 11 13 310 1583 1877 3.64E-13 77 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9QYE0 CHOYP_LOC100695438.1.1 m.8594 sp PLAG1_MOUSE 49.333 225 105 3 576 800 21 236 3.64E-66 235 PLAG1_MOUSE reviewed Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein) Plag1 Mus musculus (Mouse) 499 gland morphogenesis [GO:0022612]; multicellular organism growth [GO:0035264]; negative regulation of gene expression [GO:0010629]; organ growth [GO:0035265]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; prostate gland growth [GO:0060736] GO:0000978; GO:0000981; GO:0001077; GO:0005634; GO:0010628; GO:0010629; GO:0022612; GO:0035264; GO:0035265; GO:0045944; GO:0046872; GO:0060252; GO:0060736 0 0 0 0 Q9R1R2 CHOYP_BRAFLDRAFT_71615.3.3 m.64625 sp TRIM3_MOUSE 27.642 123 85 3 34 153 622 743 3.64E-09 58.9 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; B3EWZ5 CHOYP_LOC100207753.3.3 m.13544 sp MLRP1_ACRMI 32.173 948 502 35 601 1495 760 1619 3.65E-102 367 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O17320 CHOYP_ACT3A.1.1 m.25941 sp ACT_CRAGI 93.868 212 12 1 1 212 1 211 3.65E-144 410 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P05099 CHOYP_LOC100486063.1.9 m.4582 sp MATN1_CHICK 29.742 427 268 10 22 423 30 449 3.65E-48 179 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P54213 CHOYP_BRAFLDRAFT_118451.1.1 m.18928 sp CATR_DUNSA 45.638 149 80 1 74 222 22 169 3.65E-38 133 CATR_DUNSA reviewed Caltractin (Centrin) 0 Dunaliella salina (Green alga) (Protococcus salinus) 169 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005509; GO:0007067; GO:0051301 0 0 0 PF13499; P68202 CHOYP_LOC101164670.1.1 m.65938 sp RS27A_PLUXY 92.045 88 7 0 1 88 1 88 3.65E-48 154 RS27A_PLUXY reviewed Ubiquitin-40S ribosomal protein S27a [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] 0 Plutella xylostella (Diamondback moth) (Plutella maculipennis) 155 translation [GO:0006412] GO:0003735; GO:0005634; GO:0005840; GO:0006412; GO:0046872 0 0 0 PF01599;PF00240; Q03112 CHOYP_LOC664087.1.1 m.19351 sp EVI1_HUMAN 58.421 190 64 5 80 262 121 302 3.65E-61 225 EVI1_HUMAN reviewed MDS1 and EVI1 complex locus protein EVI1 (Ecotropic virus integration site 1 protein homolog) (EVI-1) MECOM EVI1 Homo sapiens (Human) 1051 "apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of JNK cascade [GO:0046329]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell cycle [GO:0051726]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006351; GO:0006915; GO:0016235; GO:0016607; GO:0018024; GO:0030154; GO:0042803; GO:0043069; GO:0043231; GO:0045892; GO:0045893; GO:0046329; GO:0046872; GO:0051726; GO:0071425 0 0 0 PF00096;PF13912; Q09621 CHOYP_LOC575771.3.3 m.45383 sp LACT2_CAEEL 33.257 439 263 8 9 426 26 455 3.65E-71 234 LACT2_CAEEL reviewed Beta-lactamase domain-containing protein 2 lact-2 ZK945.1 Caenorhabditis elegans 473 0 GO:0016021 0 0 0 PF00144; Q14517 CHOYP_FAT1.3.4 m.57707 sp FAT1_HUMAN 26.644 289 166 12 1 273 720 978 3.65E-13 73.6 FAT1_HUMAN reviewed "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; single organismal cell-cell adhesion [GO:0016337] GO:0005509; GO:0005634; GO:0005886; GO:0005887; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016337; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q14CW9 CHOYP_AT7L3.2.2 m.30968 sp AT7L3_HUMAN 48.837 301 144 7 21 317 17 311 3.65E-74 238 AT7L3_HUMAN reviewed Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) ATXN7L3 Homo sapiens (Human) 347 "histone deubiquitination [GO:0016578]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000124; GO:0003713; GO:0006351; GO:0008270; GO:0016578; GO:0030374; GO:0045893; GO:0071819 0 0 0 PF08313;PF08209; Q6PBY7 CHOYP_BRAFLDRAFT_282065.1.2 m.590 sp TPC13_DANRE 65.188 293 99 2 4 295 113 403 3.65E-137 397 TPC13_DANRE reviewed Trafficking protein particle complex subunit 13 trappc13 zgc:73187 Danio rerio (Zebrafish) (Brachydanio rerio) 412 0 0 0 0 0 PF06159; Q6VVW5 CHOYP_DVIR_GJ23465.1.1 m.41947 sp ANPRB_MOUSE 57.787 244 102 1 1 243 800 1043 3.65E-93 298 ANPRB_MOUSE reviewed Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) Npr2 Mus musculus (Mouse) 1047 bone development [GO:0060348]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; negative regulation of meiotic cell cycle [GO:0051447]; negative regulation of oocyte maturation [GO:1900194]; ossification [GO:0001503]; receptor guanylyl cyclase signaling pathway [GO:0007168]; single organism reproductive process [GO:0044702] GO:0001503; GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007168; GO:0008074; GO:0016941; GO:0017046; GO:0035556; GO:0042562; GO:0042802; GO:0044702; GO:0051447; GO:0060348; GO:0097011; GO:1900194 0 0 0 PF01094;PF00211;PF07714; Q7ZWG6 CHOYP_PCFT.1.1 m.24411 sp PCFT_DANRE 26.667 300 206 9 2 296 188 478 3.65E-25 107 PCFT_DANRE reviewed Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) 481 transmembrane transport [GO:0055085] GO:0005542; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q8CA72 CHOYP_BRAFLDRAFT_63247.1.1 m.20328 sp GAN_MOUSE 29.134 127 75 4 1 126 306 418 3.65E-09 57 GAN_MOUSE reviewed Gigaxonin Gan Mus musculus (Mouse) 597 cytoskeleton organization [GO:0007010]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005737; GO:0005856; GO:0007010; GO:0016567; GO:0031463; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H2C0}. 0 0 PF07707;PF00651;PF01344; Q8N0W5 CHOYP_LOC100369022.1.1 m.62978 sp IQCK_HUMAN 39.2 250 111 4 4 243 46 264 3.65E-49 167 IQCK_HUMAN reviewed IQ domain-containing protein K IQCK Homo sapiens (Human) 287 0 0 0 0 0 0 Q8N0W5 CHOYP_LOC658706.1.1 m.21425 sp IQCK_HUMAN 39.2 250 111 4 4 243 46 264 3.65E-49 167 IQCK_HUMAN reviewed IQ domain-containing protein K IQCK Homo sapiens (Human) 287 0 0 0 0 0 0 Q8R151 CHOYP_LOC100371500.1.7 m.4423 sp ZNFX1_MOUSE 36.069 987 537 22 1 931 523 1471 3.65E-169 553 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8TDY8 CHOYP_LOC100119066.1.1 m.27557 sp IGDC4_HUMAN 27.097 155 89 5 38 191 247 378 3.65E-07 55.1 IGDC4_HUMAN reviewed Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36) IGDCC4 DDM36 KIAA1628 NOPE Homo sapiens (Human) 1250 0 GO:0005886; GO:0016021 0 0 0 PF00041;PF07679; Q9MYM7 CHOYP_LOC100891122.1.1 m.34285 sp B3GT1_PONPY 30.435 253 168 5 77 325 73 321 3.65E-41 149 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9NNW5 CHOYP_LOC585638.1.1 m.10100 sp WDR6_HUMAN 26.695 708 352 23 1 632 487 1103 3.65E-56 209 WDR6_HUMAN reviewed WD repeat-containing protein 6 WDR6 Homo sapiens (Human) 1121 cell cycle arrest [GO:0007050]; negative regulation of autophagy [GO:0010507]; negative regulation of cell proliferation [GO:0008285] GO:0005737; GO:0007050; GO:0008285; GO:0010507; GO:0044822 0 0 0 PF00400; Q9NUV9 CHOYP_GIMA7.4.4 m.55138 sp GIMA4_HUMAN 39.552 268 157 2 220 484 22 287 3.65E-58 199 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9UEE5 CHOYP_STK17A.1.1 m.24446 sp ST17A_HUMAN 48.361 366 165 8 33 376 50 413 3.65E-111 336 ST17A_HUMAN reviewed Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1) STK17A DRAK1 Homo sapiens (Human) 414 apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein phosphorylation [GO:0006468]; regulation of reactive oxygen species metabolic process [GO:2000377] GO:0004674; GO:0005524; GO:0005634; GO:0006468; GO:0006915; GO:0035556; GO:0043065; GO:2000271; GO:2000377 0 0 0 PF00069; Q9UGM3 CHOYP_DMBT1.26.34 m.50606 sp DMBT1_HUMAN 58.416 101 40 2 483 581 102 202 3.65E-29 127 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9VBP3 CHOYP_NAEGRDRAFT_73890.1.1 m.64102 sp TNKS_DROME 35.811 148 64 5 836 969 1035 1165 3.65E-12 74.3 TNKS_DROME reviewed Tankyrase (dTNKS) (EC 2.4.2.30) (Poly [ADP-ribose] polymerase) Tnks tankyrase CG4719 Drosophila melanogaster (Fruit fly) 1181 chaeta development [GO:0022416]; protein ADP-ribosylation [GO:0006471]; regulation of proteasome assembly [GO:0090364]; wing disc development [GO:0035220] GO:0003950; GO:0006471; GO:0022416; GO:0035220; GO:0046872; GO:0090364; GO:0097110 0 0 0 PF00023;PF12796;PF00644;PF07647; Q9Y3I1 CHOYP_LOC100378339.1.1 m.61769 sp FBX7_HUMAN 34.128 545 282 17 4 516 1 500 3.65E-68 231 FBX7_HUMAN reviewed F-box only protein 7 FBXO7 FBX7 Homo sapiens (Human) 522 mitophagy [GO:0000422]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of lymphocyte differentiation [GO:0045620]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000422; GO:0004842; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006511; GO:0006626; GO:0016567; GO:0031647; GO:0043234; GO:0045620; GO:0045736; GO:2000134 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF11566; O46639 CHOYP_TRHR1B.1.1 m.34749 sp TRFR_BOVIN 24.167 360 231 13 62 396 29 371 3.66E-11 67.8 TRFR_BOVIN reviewed Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Bos taurus (Bovine) 398 0 GO:0004997; GO:0005886; GO:0016021 0 0 0 PF00001; O54921 CHOYP_PLXB2.2.2 m.47843 sp EXOC2_RAT 30.973 113 61 2 219 316 1 111 3.66E-08 59.7 EXOC2_RAT reviewed Exocyst complex component 2 (Exocyst complex component Sec5) (rSec5) Exoc2 Sec5 Sec5l1 Rattus norvegicus (Rat) 924 exocyst assembly [GO:0001927]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031] GO:0000145; GO:0001927; GO:0006893; GO:0015031 0 0 0 PF01833; P0C6B8 CHOYP_LOC100367084.19.22 m.58095 sp SVEP1_RAT 24.377 361 211 8 2 304 749 1105 3.66E-16 87.8 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P0CJ62 CHOYP_LOC100891926.1.1 m.2933 sp RITA1_XENLA 32.5 160 76 7 10 156 5 145 3.66E-09 58.2 RITA1_XENLA reviewed RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein) rita1 rita Xenopus laevis (African clawed frog) 239 negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168] GO:0000122; GO:0005634; GO:0005737; GO:0007219; GO:0015631; GO:0022008; GO:0045746; GO:0051168 0 0 0 PF17066; P27701 CHOYP_LOC751836.6.6 m.58599 sp CD82_HUMAN 29.224 219 134 6 85 292 52 260 3.66E-15 77 CD82_HUMAN reviewed CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) CD82 KAI1 SAR2 ST6 TSPAN27 Homo sapiens (Human) 267 cell surface receptor signaling pathway [GO:0007166] GO:0005886; GO:0005887; GO:0007166; GO:0070062 0 0 0 PF00335; P31944 CHOYP_BRAFLDRAFT_66705.1.1 m.47148 sp CASPE_HUMAN 28.033 239 146 6 191 420 20 241 3.66E-20 92.4 CASPE_HUMAN reviewed "Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]" CASP14 Homo sapiens (Human) 242 cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424] GO:0004197; GO:0005634; GO:0005737; GO:0008544; GO:0031012; GO:0031424; GO:0045095; GO:0070062; GO:0070268; GO:0097153 0 0 0 0 P35570 CHOYP_IRS1.1.1 m.922 sp IRS1_RAT 43.874 253 109 5 30 249 11 263 3.66E-57 221 IRS1_RAT reviewed Insulin receptor substrate 1 (IRS-1) (pp185) Irs1 Irs-1 Rattus norvegicus (Rat) 1235 aging [GO:0007568]; cellular response to angiotensin [GO:1904385]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to radiation [GO:0071478]; insulin-like growth factor receptor signaling pathway [GO:0048009]; insulin receptor signaling pathway [GO:0008286]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin secretion [GO:0046676]; negative regulation of somatostatin secretion [GO:0090275]; positive regulation of glucagon secretion [GO:0070094]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphorylation [GO:0042327]; protein heterooligomerization [GO:0051291]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to peptide hormone [GO:0043434] GO:0005068; GO:0005080; GO:0005158; GO:0005159; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005899; GO:0007568; GO:0008286; GO:0014823; GO:0019901; GO:0019904; GO:0031000; GO:0042169; GO:0042327; GO:0043231; GO:0043434; GO:0043548; GO:0043552; GO:0046627; GO:0046628; GO:0046676; GO:0048009; GO:0051291; GO:0060397; GO:0070094; GO:0071478; GO:0090275; GO:1904385; GO:1990416 0 0 cd01204; PF02174;PF00169; P51989 CHOYP_PININ.1.1 m.56669 sp RO21_XENLA 49.474 95 48 0 1 95 102 196 3.66E-22 92 RO21_XENLA reviewed Heterogeneous nuclear ribonucleoprotein A2 homolog 1 (hnRNP A2(A)) 0 Xenopus laevis (African clawed frog) 346 0 GO:0000166; GO:0003723; GO:0005634; GO:0030529 0 0 0 PF00076; P56597 CHOYP_BRAFLDRAFT_61845.1.1 m.37831 sp NDK5_HUMAN 67.839 199 64 0 17 215 4 202 3.66E-107 310 NDK5_HUMAN reviewed Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (Inhibitor of p53-induced apoptosis-beta) (IPIA-beta) (Testis-specific nm23 homolog) (nm23-H5) NME5 Homo sapiens (Human) 212 cilium assembly [GO:0042384]; CTP biosynthetic process [GO:0006241]; epithelial cilium movement [GO:0003351]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; nucleoside metabolic process [GO:0009116]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228]; ventricular system development [GO:0021591] GO:0003351; GO:0004550; GO:0005622; GO:0006183; GO:0006228; GO:0006241; GO:0007283; GO:0007286; GO:0009116; GO:0021591; GO:0036126; GO:0042384; GO:1902176 0 0 0 PF05186;PF00334; P84157 CHOYP_BRAFLDRAFT_275293.1.1 m.16193 sp MXRA7_HUMAN 42.857 56 32 0 103 158 147 202 3.66E-08 53.9 MXRA7_HUMAN reviewed Matrix-remodeling-associated protein 7 (Transmembrane anchor protein 1) MXRA7 TMAP1 Homo sapiens (Human) 204 0 GO:0016021 0 0 0 0 P86856 CHOYP_MANL.8.9 m.48353 sp MANL_MYTCA 39.71 345 138 10 53 355 2 318 3.66E-68 220 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q01484 CHOYP_AFUA_1G01020.30.50 m.39361 sp ANK2_HUMAN 33.667 300 199 0 1 300 486 785 3.66E-48 176 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q03601 CHOYP_NHL1.3.6 m.3821 sp NHL1_CAEEL 26.563 128 82 4 12 127 788 915 3.66E-07 50.8 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q11076 CHOYP_BRAFLDRAFT_85147.1.1 m.60258 sp UBC17_CAEEL 40.994 322 148 7 669 961 341 649 3.66E-64 234 UBC17_CAEEL reviewed Probable ubiquitin-conjugating enzyme protein 17 ubc-17 B0403.2 Caenorhabditis elegans 728 regulation of signal transduction [GO:0009966] GO:0004842; GO:0005737; GO:0009966; GO:0016874 0 0 0 PF00179; Q29081 CHOYP_LOC100372755.1.1 m.18558 sp PMVK_PIG 48.705 193 97 1 6 198 2 192 3.66E-67 207 PMVK_PIG reviewed Phosphomevalonate kinase (PMKase) (EC 2.7.4.2) PMVK Sus scrofa (Pig) 192 "cholesterol biosynthetic process [GO:0006695]; isopentenyl diphosphate biosynthetic process, mevalonate pathway [GO:0019287]" GO:0004631; GO:0005524; GO:0005777; GO:0006695; GO:0019287 PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3. 0 0 PF04275; Q29116 CHOYP_BRAFLDRAFT_125263.1.9 m.7395 sp TENA_PIG 42.194 237 132 3 98 332 1500 1733 3.66E-54 194 TENA_PIG reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) 1746 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041; Q2KHZ4 CHOYP_LOC100704237.1.2 m.6768 sp MIA40_BOVIN 36.62 142 83 3 1 141 1 136 3.66E-25 97.1 MIA40_BOVIN reviewed Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) CHCHD4 MIA40 Bos taurus (Bovine) 137 'de novo' posttranslational protein folding [GO:0051084]; protein import into mitochondrial intermembrane space [GO:0045041]; protein maturation by protein folding [GO:0022417] GO:0005758; GO:0015035; GO:0022417; GO:0045041; GO:0051084 0 0 0 PF06747; Q3UIR3 CHOYP_LOC100368715.3.3 m.62942 sp DTX3L_MOUSE 54.359 195 88 1 465 659 555 748 3.66E-60 218 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q4KLN4 CHOYP_BRAFLDRAFT_64464.1.2 m.50913 sp GLE1_RAT 39.65 343 199 7 1211 1548 357 696 3.66E-72 259 GLE1_RAT reviewed Nucleoporin GLE1 (GLE1-like protein) Gle1 Gle1l Rattus norvegicus (Rat) 698 mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]; regulation of translational initiation [GO:0006446]; regulation of translational termination [GO:0006449] GO:0000822; GO:0005543; GO:0005737; GO:0006406; GO:0006446; GO:0006449; GO:0015031; GO:0016973; GO:0031369; GO:0044614 0 0 0 PF07817; Q5RJ80 CHOYP_LOC100705460.1.3 m.4908 sp CAPR2_DANRE 33.913 115 67 3 105 215 802 911 3.66E-11 65.5 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q6NWH5 CHOYP_LOC101070658.1.1 m.23545 sp TMM11_DANRE 44.099 161 85 2 10 165 25 185 3.66E-43 144 TMM11_DANRE reviewed "Transmembrane protein 11, mitochondrial" tmem11 zgc:110086 Danio rerio (Zebrafish) (Brachydanio rerio) 187 mitochondrion organization [GO:0007005] GO:0007005; GO:0031305 0 0 0 PF14972; Q6P9Z4 CHOYP_LOC100901991.1.1 m.1305 sp FEM1A_DANRE 26.129 620 426 14 29 635 17 617 3.66E-45 173 FEM1A_DANRE reviewed Protein fem-1 homolog A (FEM1a) (FEM1-alpha) fem1a zgc:63483 Danio rerio (Zebrafish) (Brachydanio rerio) 617 regulation of ubiquitin-protein transferase activity [GO:0051438] GO:0004842; GO:0005737; GO:0051438 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q6XDT4 CHOYP_IKZF1.1.1 m.34373 sp IKZF_OIKDI 42 50 29 0 615 664 494 543 3.66E-07 57 IKZF_OIKDI reviewed Ikaros family zinc finger protein (Ikaros-like transcription factor) (OIL) 0 Oikopleura dioica (Tunicate) 562 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q7TM99 CHOYP_DANA_GF11460.1.1 m.33680 sp MOT9_MOUSE 23.381 556 344 15 15 563 8 488 3.66E-26 115 MOT9_MOUSE reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) Slc16a9 Mct9 Mus musculus (Mouse) 508 urate metabolic process [GO:0046415] GO:0005886; GO:0008028; GO:0015293; GO:0016021; GO:0046415 0 0 cd06174; PF07690; Q7W977 CHOYP_BRAFLDRAFT_68840.1.1 m.28221 sp ECTD_BORPA 25 256 158 10 25 255 37 283 3.66E-12 68.9 ECTD_BORPA reviewed Ectoine dioxygenase (EC 1.14.11.-) (Ectoine hydroxylase) ectD BPP1891 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 308 ectoine catabolic process [GO:0042400] GO:0005506; GO:0016706; GO:0042400 0 0 0 PF05721; Q86Y13 CHOYP_NEMVEDRAFT_V1G240601.6.6 m.63814 sp DZIP3_HUMAN 26.846 149 102 3 3 145 393 540 3.66E-07 58.2 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8C525 CHOYP_LOC100370446.2.12 m.22575 sp M21D2_MOUSE 27.517 149 100 5 67 214 181 322 3.66E-08 58.9 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8HXX6 CHOYP_BRAFLDRAFT_280343.1.1 m.41318 sp SAP3_MACFA 33.526 173 103 4 54 215 16 187 3.66E-30 113 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8K354 CHOYP_CBR1.1.1 m.62756 sp CBR3_MOUSE 40.794 277 148 5 21 293 6 270 3.66E-67 214 CBR3_MOUSE reviewed Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3) Cbr3 Mus musculus (Mouse) 277 cognition [GO:0050890]; phylloquinone catabolic process [GO:0042376] GO:0000253; GO:0004090; GO:0005615; GO:0005654; GO:0005737; GO:0005829; GO:0042376; GO:0050890; GO:0070402 0 0 0 PF00106; Q8N8A2 CHOYP_LOC100639010.3.9 m.39718 sp ANR44_HUMAN 30.573 314 167 5 288 567 43 339 3.66E-36 147 ANR44_HUMAN reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) 993 0 0 0 0 0 PF00023;PF12796; Q8T940 CHOYP_LOC100747402.1.1 m.43243 sp UBX_JUNCO 78.652 89 16 2 169 255 140 227 3.66E-42 148 UBX_JUNCO reviewed Homeotic protein ultrabithorax (JcUbx) Ubx Junonia coenia (Peacock butterfly) (Precis coenia) 253 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; Q96M89 CHOYP_LOC100371694.1.1 m.18876 sp CC138_HUMAN 39.175 485 271 8 106 576 177 651 3.66E-95 308 CC138_HUMAN reviewed Coiled-coil domain-containing protein 138 CCDC138 Homo sapiens (Human) 665 0 0 0 0 0 0 Q96N23 CHOYP_LOC575277.1.2 m.22923 sp CFA54_HUMAN 37.915 211 122 4 434 641 782 986 3.66E-28 124 CFA54_HUMAN reviewed Cilia- and flagella-associated protein 54 CFAP54 C12orf55 C12orf63 Homo sapiens (Human) 3096 cell differentiation [GO:0030154]; cilium assembly [GO:0042384]; cilium movement involved in cell motility [GO:0060294]; spermatogenesis [GO:0007283] GO:0005737; GO:0005930; GO:0007283; GO:0030154; GO:0042384; GO:0060294 0 0 0 PF14858; Q9C005 CHOYP_BRAFLDRAFT_202721.1.2 m.18687 sp DPY30_HUMAN 71.233 73 20 1 27 99 25 96 3.66E-29 103 DPY30_HUMAN reviewed Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) DPY30 Homo sapiens (Human) 99 "chromatin silencing at telomere [GO:0006348]; endosomal transport [GO:0016197]; histone H3-K4 methylation [GO:0051568]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005654; GO:0005794; GO:0005802; GO:0006348; GO:0006351; GO:0016197; GO:0018024; GO:0035097; GO:0042802; GO:0042803; GO:0044666; GO:0048188; GO:0051568 0 0 0 PF05186; Q9DFQ7 CHOYP_BRAFLDRAFT_273508.4.4 m.61166 sp RL24_GILMI 67.089 158 45 2 1 154 1 155 3.66E-67 204 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9N2N6 CHOYP_LOC100367715.1.1 m.65917 sp TBB_EUPFO 89.286 56 6 0 20 75 5 60 3.66E-30 117 TBB_EUPFO reviewed Tubulin beta chain (Beta-tubulin) 0 Euplotes focardii 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q9VCZ3 CHOYP_APOA.1.1 m.25621 sp OCTB1_DROME 50.299 334 159 5 19 350 91 419 3.66E-106 325 OCTB1_DROME reviewed Octopamine receptor beta-1R (DmOA2) (DmOct-beta-1R) Octbeta1R oa2 Oct-beta-1 CG6919 Drosophila melanogaster (Fruit fly) 508 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; serotonin receptor signaling pathway [GO:0007210] GO:0004935; GO:0004989; GO:0004993; GO:0005887; GO:0007186; GO:0007188; GO:0007189; GO:0007210; GO:0008227; GO:0010579; GO:0016021; GO:0045886 0 0 0 PF00001; B3EWZ3 CHOYP_LOC101236385.3.6 m.4348 sp CADN_ACRMI 40.553 434 245 6 317 740 132 562 3.67E-80 284 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; D3ZL52 CHOYP_LOC100163889.1.1 m.29544 sp SESQ1_RAT 38.197 233 126 2 1 233 1 215 3.67E-48 162 SESQ1_RAT reviewed Sesquipedalian-1 (Ses1) (27 kDa inositol polyphosphate phosphatase interacting protein A) (IPIP27A) Fam109a Rattus norvegicus (Rat) 234 "endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0001881; GO:0005769; GO:0005802; GO:0005829; GO:0007032; GO:0030136; GO:0042147; GO:0055037 0 0 0 PF00169; E1BVR9 CHOYP_BRAFLDRAFT_68822.1.1 m.33865 sp HENMT_CHICK 36.667 270 165 3 60 326 12 278 3.67E-59 200 HENMT_CHICK reviewed Small RNA 2'-O-methyltransferase (EC 2.1.1.n8) (HEN1 methyltransferase homolog 1) HENMT1 Gallus gallus (Chicken) 376 gene silencing by RNA [GO:0031047]; piRNA metabolic process [GO:0034587]; RNA methylation [GO:0001510] GO:0001510; GO:0003723; GO:0008171; GO:0008173; GO:0031047; GO:0034587; GO:0043186; GO:0046872 0 0 0 0 O01359 CHOYP_RLA1.5.12 m.15482 sp RLA1_OSCTI 62.5 112 42 0 1 112 1 112 3.67E-34 117 RLA1_OSCTI reviewed 60S acidic ribosomal protein P1 (Ribosomal protein RPL-21) rpl-21 Oscheius tipulae 112 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O01359 CHOYP_RLA1.6.12 m.16489 sp RLA1_OSCTI 62.5 112 42 0 1 112 1 112 3.67E-34 117 RLA1_OSCTI reviewed 60S acidic ribosomal protein P1 (Ribosomal protein RPL-21) rpl-21 Oscheius tipulae 112 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O14929 CHOYP_LOC100901947.1.1 m.7835 sp HAT1_HUMAN 50.75 400 194 2 6 403 19 417 3.67E-146 424 HAT1_HUMAN reviewed Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1) HAT1 KAT1 Homo sapiens (Human) 419 chromatin modification [GO:0016568]; chromatin silencing at telomere [GO:0006348]; DNA packaging [GO:0006323]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone H4 acetylation [GO:0043967]; internal protein amino acid acetylation [GO:0006475]; response to nutrient [GO:0007584] GO:0000784; GO:0000790; GO:0004402; GO:0005634; GO:0005654; GO:0005737; GO:0006323; GO:0006335; GO:0006336; GO:0006348; GO:0006475; GO:0007584; GO:0010485; GO:0016363; GO:0016568; GO:0042393; GO:0043231; GO:0043234; GO:0043967 0 0 0 PF10394; O17320 CHOYP_CPIPJ_CPIJ005785.1.1 m.13045 sp ACT_CRAGI 54.795 73 24 2 1 66 1 71 3.67E-16 75.5 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O73746 CHOYP_LOC100489929.1.1 m.51437 sp TIMP3_XENLA 31.771 192 105 8 1 175 1 183 3.67E-13 68.2 TIMP3_XENLA reviewed Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) timp3 Xenopus laevis (African clawed frog) 214 0 GO:0005578; GO:0008191; GO:0046872 0 0 0 PF00965; O75382 CHOYP_BRAFLDRAFT_99993.2.4 m.20464 sp TRIM3_HUMAN 23.79 248 149 9 114 340 459 687 3.67E-07 55.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75832 CHOYP_LOC100371457.1.1 m.12814 sp PSD10_HUMAN 51.163 215 105 0 9 223 10 224 3.67E-72 222 PSD10_HUMAN reviewed 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 Homo sapiens (Human) 226 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteasome regulatory particle assembly [GO:0070682]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000122; GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005838; GO:0006521; GO:0006915; GO:0007253; GO:0008134; GO:0030307; GO:0031145; GO:0031398; GO:0032088; GO:0032436; GO:0033209; GO:0038061; GO:0038095; GO:0043066; GO:0043161; GO:0043409; GO:0043488; GO:0043518; GO:0045111; GO:0045737; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070682; GO:0090090; GO:0090201; GO:0090263 0 0 0 PF00023;PF12796; P0CT40 CHOYP_LOC100697572.2.2 m.35352 sp TF29_SCHPO 34.247 146 96 0 8 153 561 706 3.67E-26 106 TF29_SCHPO reviewed Transposon Tf2-9 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-9 SPBC9B6.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0005737; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P10881 CHOYP_LA.1.1 m.65962 sp LA_BOVIN 40.401 349 199 5 37 383 12 353 3.67E-78 249 LA_BOVIN reviewed Lupus La protein homolog (La autoantigen homolog) (La ribonucleoprotein) SSB Bos taurus (Bovine) 404 RNA processing [GO:0006396] GO:0000166; GO:0000784; GO:0006396; GO:0030529; GO:0044822 0 0 0 PF05383;PF00076;PF08777; P46782 CHOYP_RS5.2.2 m.42664 sp RS5_HUMAN 92.513 187 14 0 67 253 18 204 3.67E-128 364 RS5_HUMAN reviewed "40S ribosomal protein S5 [Cleaved into: 40S ribosomal protein S5, N-terminally processed]" RPS5 Homo sapiens (Human) 204 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational fidelity [GO:0006450]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000028; GO:0000184; GO:0003723; GO:0003729; GO:0003735; GO:0005654; GO:0005829; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006450; GO:0006614; GO:0016020; GO:0019083; GO:0019843; GO:0022627; GO:0030529; GO:0031012; GO:0044822; GO:0070062 0 0 cd14867; PF00177; P49442 CHOYP_LOC555899.1.1 m.27603 sp INPP_MOUSE 50 98 49 0 8 105 4 101 3.67E-28 108 INPP_MOUSE reviewed Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) Inpp1 Mus musculus (Mouse) 396 inositol phosphate dephosphorylation [GO:0046855]; phosphatidylinositol phosphorylation [GO:0046854]; signal transduction [GO:0007165] GO:0000287; GO:0004441; GO:0005737; GO:0007165; GO:0046854; GO:0046855 PATHWAY: Signal transduction; phosphatidylinositol signaling pathway. 0 0 PF00459; P51644 CHOYP_ARF4.1.2 m.8401 sp ARF4_XENLA 86.111 180 25 0 1 180 1 180 3.67E-116 329 ARF4_XENLA reviewed ADP-ribosylation factor 4 arf4 Xenopus laevis (African clawed frog) 180 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; P62243 CHOYP_RS8.5.14 m.32291 sp RS8_RAT 80.172 116 23 0 1 116 1 116 3.67E-65 199 RS8_RAT reviewed 40S ribosomal protein S8 Rps8 Rattus norvegicus (Rat) 208 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000462; GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0030529 0 0 0 PF01201; P83298 CHOYP_FIBC.1.1 m.27263 sp FIBC_LUMRU 37.705 244 138 5 37 270 1 240 3.67E-44 152 FIBC_LUMRU reviewed "Fibrinolytic enzyme, isozyme C (F-II) (EC 3.4.21.-)" 0 Lumbricus rubellus (Humus earthworm) 242 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730] GO:0004252; GO:0007596; GO:0042730 0 0 cd00190; PF00089; Q01538 CHOYP_MYT1.1.2 m.9748 sp MYT1_HUMAN 47.573 309 127 7 414 696 800 1099 3.67E-77 272 MYT1_HUMAN reviewed Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein) MYT1 KIAA0835 KIAA1050 MTF1 MYTI PLPB1 Homo sapiens (Human) 1121 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0007399; GO:0008270; GO:0030154 0 0 0 PF08474;PF01530; Q2HJJ0 CHOYP_LOC100369926.3.6 m.34422 sp KLC4_BOVIN 32 125 76 4 219 342 262 378 3.67E-07 56.6 KLC4_BOVIN reviewed Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) KLC4 KNSL8 Bos taurus (Bovine) 616 0 GO:0003777; GO:0005737; GO:0005871; GO:0005874 0 0 0 PF13374; Q3ZBP3 CHOYP_LOC100744046.2.2 m.65495 sp RBMS1_BOVIN 70.286 175 46 2 28 196 57 231 3.67E-82 258 RBMS1_BOVIN reviewed "RNA-binding motif, single-stranded-interacting protein 1" RBMS1 Bos taurus (Bovine) 403 DNA replication [GO:0006260] GO:0000166; GO:0003677; GO:0005634; GO:0006260; GO:0044822 0 0 0 PF00076; Q460N5 CHOYP_PARP14.8.22 m.35311 sp PAR14_HUMAN 34 150 98 1 374 523 1027 1175 3.67E-17 89.7 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4UMH6 CHOYP_ANR35.1.1 m.26956 sp Y381_RICFE 32.813 128 82 1 58 181 1007 1134 3.67E-14 76.3 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q54KA7 CHOYP_AFUA_1G01020.42.50 m.61398 sp SECG_DICDI 36.409 401 223 5 5 373 66 466 3.67E-53 192 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5SPX1 CHOYP_LOC100367713.1.1 m.16115 sp CC157_MOUSE 31.629 626 386 11 1 606 1 604 3.67E-77 267 CC157_MOUSE reviewed Coiled-coil domain-containing protein 157 Ccdc157 Kiaa1656 Mus musculus (Mouse) 718 0 0 0 0 0 0 Q5ZIJ9 CHOYP_LOC101067376.1.1 m.40668 sp MIB2_CHICK 33.38 710 408 12 1 676 137 815 3.67E-123 398 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6AZB8 CHOYP_LOC100573409.2.2 m.58288 sp HARB1_DANRE 38.202 89 52 1 22 107 185 273 3.67E-13 67.4 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6GNP2 CHOYP_Z652B.1.1 m.19840 sp Z652A_XENLA 26.014 296 186 9 515 793 141 420 3.67E-12 73.6 Z652A_XENLA reviewed Zinc finger protein 652-A znf652-a Xenopus laevis (African clawed frog) 625 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q6PFY8 CHOYP_LOC100992685.1.1 m.51875 sp TRI45_MOUSE 24.294 177 117 8 13 175 135 308 3.67E-06 49.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8TCA0 CHOYP_DANA_GF21583.1.1 m.26752 sp LRC20_HUMAN 32.727 110 74 0 8 117 52 161 3.67E-17 76.6 LRC20_HUMAN reviewed Leucine-rich repeat-containing protein 20 LRRC20 UNQ2429/PRO4989 Homo sapiens (Human) 184 0 0 0 0 0 PF00560;PF13855; Q95KI5 CHOYP_BRAFLDRAFT_79652.1.1 m.44322 sp S45A3_MACFA 35.032 471 239 7 61 531 16 419 3.67E-89 290 S45A3_MACFA reviewed Solute carrier family 45 member 3 (Prostate cancer-associated protein 6) (Prostein) SLC45A3 PCANAP6 PRST QmoA-10594 QtrA-11310 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 553 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 0 PF07690; Q9BE18 CHOYP_PF14_0588.1.2 m.33379 sp MAGE1_MACFA 26.525 377 249 7 1205 1573 58 414 3.67E-16 88.2 MAGE1_MACFA reviewed Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (MAGE-E1 antigen) MAGEE1 QflA-10248 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 957 0 GO:0005634; GO:0005886; GO:0030425; GO:0045211; GO:0048471 0 0 0 PF01454; Q9CRB3 CHOYP_LOC100313757.1.1 m.65129 sp HIUH_MOUSE 51.327 113 52 3 9 119 7 118 3.67E-32 112 HIUH_MOUSE reviewed 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-related protein) Urah Mus musculus (Mouse) 118 purine nucleobase metabolic process [GO:0006144]; urate catabolic process [GO:0019628] GO:0005739; GO:0005777; GO:0006144; GO:0016787; GO:0019628; GO:0033971 PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from urate: step 2/3. 0 0 PF00576; Q9SZJ2 CHOYP_LOC100367312.11.13 m.40492 sp GRDP2_ARATH 40.845 284 155 5 5 278 15 295 3.67E-57 213 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; D3ZTX0 CHOYP_TMED7.2.3 m.28259 sp TMED7_RAT 65.217 184 63 1 20 203 36 218 3.68E-90 266 TMED7_RAT reviewed Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) Tmed7 Rattus norvegicus (Rat) 226 protein transport [GO:0015031] GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0012507; GO:0015031; GO:0016021; GO:0030663; GO:0033116; GO:0070062 0 0 0 PF01105; F6QEU4 CHOYP_TRIM2.31.59 m.35842 sp LIN41_XENTR 20.38 790 469 19 30 680 46 814 3.68E-37 152 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; G5EFX6 CHOYP_RL13.4.4 m.53595 sp SLIT1_CAEEL 24.176 364 213 15 107 449 34 355 3.68E-10 67 SLIT1_CAEEL reviewed Slit homolog 1 protein (Slt-1) slt-1 F40E10.4 Caenorhabditis elegans 1410 dorsal/ventral axon guidance [GO:0033563]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron migration [GO:0001764]; Roundabout signaling pathway [GO:0035385] GO:0001764; GO:0005102; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0008201; GO:0033563; GO:0035385; GO:0048495; GO:0048843 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01462; J9VY90 CHOYP_LOC100210525.1.2 m.41093 sp LAC1_CRYNH 46.535 101 48 3 59 156 52 149 3.68E-19 86.3 LAC1_CRYNH reviewed Laccase-1 (EC 1.10.3.2) (Diphenol oxidase 1) LAC1 CNAG_03465 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 624 0 GO:0005507; GO:0005576; GO:0005618; GO:0052716 0 0 0 PF00394;PF07731;PF07732; O15031 CHOYP_PLXA3.1.1 m.51322 sp PLXB2_HUMAN 25.815 767 427 36 122 822 328 1018 3.68E-46 184 PLXB2_HUMAN reviewed Plexin-B2 (MM1) PLXNB2 KIAA0315 Homo sapiens (Human) 1838 brain development [GO:0007420]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0001843; GO:0001932; GO:0002116; GO:0005887; GO:0007156; GO:0007162; GO:0007405; GO:0007420; GO:0008360; GO:0009986; GO:0010976; GO:0017154; GO:0030334; GO:0043087; GO:0050772; GO:0070062; GO:0071526; GO:1902287; GO:2001222 0 0 0 PF08337;PF01437;PF01403;PF01833; O96790 CHOYP_VOLCADRAFT_93060.2.2 m.26741 sp DPGN_DIPMA 33.086 269 105 10 20 213 77 345 3.68E-27 108 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P08155 CHOYP_LOC100691386.1.1 m.4540 sp KRH1_DROME 32.065 184 109 7 563 739 201 375 3.68E-16 86.7 KRH1_DROME reviewed Krueppel homolog 1 (Krueppel homologous protein 1) Kr-h1 Kr-h CG9167 Drosophila melanogaster (Fruit fly) 845 "metamorphosis [GO:0007552]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of neuron projection development [GO:0010977]; regulation of transcription, DNA-templated [GO:0006355]; response to ecdysone [GO:0035075]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0007552; GO:0010977; GO:0035075; GO:0045316; GO:0046872 0 0 0 0 P23385 CHOYP_LOC100374272.2.6 m.36533 sp GRM1_RAT 20.588 612 425 17 412 977 146 742 3.68E-14 81.3 GRM1_RAT reviewed Metabotropic glutamate receptor 1 (mGluR1) Grm1 Gprc1a Mglur1 Rattus norvegicus (Rat) 1199 "calcium-mediated signaling [GO:0019722]; chemical synaptic transmission [GO:0007268]; dimeric G-protein coupled receptor signaling pathway [GO:0038042]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; G-protein coupled receptor signaling pathway [GO:0007186]; membrane depolarization [GO:0051899]; phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [GO:0007206]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; regulation of glutamate secretion [GO:0014048]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic transmission, GABAergic [GO:0051932]" GO:0001639; GO:0004930; GO:0005887; GO:0007186; GO:0007205; GO:0007206; GO:0007216; GO:0007268; GO:0008066; GO:0014048; GO:0014069; GO:0019233; GO:0019722; GO:0030331; GO:0030424; GO:0038042; GO:0042734; GO:0042802; GO:0043197; GO:0051482; GO:0051899; GO:0051932; GO:0051966 0 0 0 PF00003;PF01094;PF10606;PF07562; P38573 CHOYP_DERE_GG14356.1.1 m.56020 sp UPK1B_BOVIN 20.588 238 158 9 20 245 14 232 3.68E-08 56.6 UPK1B_BOVIN reviewed Uroplakin-1b (UP1b) (Uroplakin Ib) (UPIb) UPK1B Bos taurus (Bovine) 260 cell surface receptor signaling pathway [GO:0007166]; epithelial cell differentiation [GO:0030855]; protein localization to cell surface [GO:0034394] GO:0005783; GO:0005886; GO:0005887; GO:0007166; GO:0016021; GO:0016324; GO:0030855; GO:0034394; GO:0070062 0 0 0 PF00335; P41381 CHOYP_IF4A1.1.1 m.996 sp IF4A8_TOBAC 58.156 423 161 2 28 450 7 413 3.68E-170 487 IF4A8_TOBAC reviewed Eukaryotic initiation factor 4A-8 (eIF-4A-8) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-8) 0 Nicotiana tabacum (Common tobacco) 413 0 GO:0003743; GO:0004386; GO:0005524 0 0 0 PF00270;PF00271; Q2FXL6 CHOYP_LOC100185549.2.6 m.35996 sp Y1819_STAA8 31.169 154 91 4 30 180 5 146 3.68E-11 62.8 Y1819_STAA8 reviewed Putative universal stress protein SAOUHSC_01819 SAOUHSC_01819 Staphylococcus aureus (strain NCTC 8325) 166 response to stress [GO:0006950] GO:0005737; GO:0006950 0 0 0 PF00582; Q460N3 CHOYP_PARP15.2.3 m.52425 sp PAR15_HUMAN 29.973 377 218 12 1141 1492 103 458 3.68E-33 142 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_AGAP_AGAP002739.2.5 m.34213 sp SVEP1_HUMAN 32.836 201 123 4 272 471 2345 2534 3.68E-25 115 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5RJ80 CHOYP_C1QL2.3.32 m.2262 sp CAPR2_DANRE 35.294 102 62 3 357 457 813 911 3.68E-09 62.8 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q62158 CHOYP_TRI23.1.7 m.665 sp TRI27_MOUSE 25.243 206 140 4 50 243 70 273 3.68E-07 53.9 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q63041 CHOYP_A1M.2.2 m.40151 sp A1M_RAT 37.692 130 76 3 42 167 1360 1488 3.68E-13 71.6 A1M_RAT reviewed Alpha-1-macroglobulin (Alpha-1-M) (Alpha-1-macroglobulin 165 kDa subunit) [Cleaved into: Alpha-1-macroglobulin 45 kDa subunit] A1m Pzp Rattus norvegicus (Rat) 1500 embryo implantation [GO:0007566] GO:0004867; GO:0005615; GO:0007566; GO:0032403; GO:0048403; GO:0048406 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q7LFX5 CHOYP_CHST15.3.3 m.40557 sp CHSTF_HUMAN 32.888 374 201 8 79 407 190 558 3.68E-54 191 CHSTF_HUMAN reviewed Carbohydrate sulfotransferase 15 (EC 2.8.2.33) (B-cell RAG-associated gene protein) (hBRAG) (N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase) (GalNAc4S-6ST) CHST15 BRAG GALNAC4S6ST KIAA0598 Homo sapiens (Human) 561 chondroitin sulfate biosynthetic process [GO:0030206]; hexose biosynthetic process [GO:0019319] GO:0000139; GO:0016021; GO:0019319; GO:0030206; GO:0050656; GO:0050659 0 0 0 0 Q7Z442 CHOYP_LOC100378512.2.6 m.31856 sp PK1L2_HUMAN 23.054 681 479 9 1883 2550 1810 2458 3.68E-57 224 PK1L2_HUMAN reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) PKD1L2 KIAA1879 PC1L2 Homo sapiens (Human) 2459 detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q86SQ7 CHOYP_SDCCAG8.1.1 m.9639 sp SDCG8_HUMAN 28.631 716 441 13 11 672 14 713 3.68E-68 241 SDCG8_HUMAN reviewed Serologically defined colon cancer antigen 8 (Antigen NY-CO-8) (Centrosomal colon cancer autoantigen protein) (hCCCAP) SDCCAG8 CCCAP NPHP10 HSPC085 Homo sapiens (Human) 713 centrosome organization [GO:0051297]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; neuron migration [GO:0001764]; tube formation [GO:0035148] GO:0000086; GO:0001764; GO:0005813; GO:0005814; GO:0005829; GO:0005911; GO:0030010; GO:0034451; GO:0035148; GO:0051297 0 0 0 PF15964; Q8NI99 CHOYP_ISCW_ISCW023908.1.1 m.51404 sp ANGL6_HUMAN 36.321 212 127 5 34 240 257 465 3.68E-37 139 ANGL6_HUMAN reviewed Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) (Angiopoietin-related protein 5) ANGPTL6 AGF ARP5 UNQ152/PRO178 Homo sapiens (Human) 470 angiogenesis [GO:0001525]; cell differentiation [GO:0030154] GO:0001525; GO:0030141; GO:0030154; GO:0070062 0 0 0 PF00147; Q96B36 CHOYP_BRAFLDRAFT_128432.1.1 m.8945 sp AKTS1_HUMAN 33.6 125 72 4 248 363 128 250 3.68E-09 60.5 AKTS1_HUMAN reviewed Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate) AKT1S1 PRAS40 Homo sapiens (Human) 256 negative regulation of cell size [GO:0045792]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of TOR signaling [GO:0032007]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of cellular response to heat [GO:1900034]; regulation of neuron apoptotic process [GO:0043523] GO:0005654; GO:0005737; GO:0005829; GO:0006469; GO:0032007; GO:0043234; GO:0043523; GO:0045792; GO:0048011; GO:1900034 0 0 0 PF15798; Q9BYN0 CHOYP_LOC100377903.1.1 m.60823 sp SRXN1_HUMAN 69.091 110 32 1 99 208 29 136 3.68E-51 164 SRXN1_HUMAN reviewed Sulfiredoxin-1 (EC 1.8.98.2) SRXN1 C20orf139 SRX Homo sapiens (Human) 137 response to oxidative stress [GO:0006979] GO:0005524; GO:0005829; GO:0006979; GO:0016667; GO:0032542 0 0 0 PF02195; Q9CXC3 CHOYP_MGME1.1.1 m.17376 sp MGME1_MOUSE 46.341 205 99 3 182 381 127 325 3.68E-52 180 MGME1_MOUSE reviewed Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-) Mgme1 Mus musculus (Mouse) 338 mitochondrial DNA repair [GO:0043504]; mitochondrial DNA replication [GO:0006264]; mitochondrial genome maintenance [GO:0000002] GO:0000002; GO:0005739; GO:0006264; GO:0008297; GO:0043504 0 0 0 0 Q9CZJ2 CHOYP_BRAFLDRAFT_208197.21.21 m.62079 sp HS12B_MOUSE 34.851 637 340 15 46 621 61 683 3.68E-114 359 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9H0H5 CHOYP_CPIPJ_CPIJ007723.2.4 m.11766 sp RGAP1_HUMAN 40.335 657 319 14 14 634 12 631 3.68E-154 461 RGAP1_HUMAN reviewed Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) RACGAP1 KIAA1478 MGCRACGAP Homo sapiens (Human) 632 "actomyosin contractile ring assembly [GO:0000915]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; embryo development [GO:0009790]; intracellular signal transduction [GO:0035556]; microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; neuroblast proliferation [GO:0007405]; positive regulation of cytokinesis [GO:0032467]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of small GTPase mediated signal transduction [GO:0051056]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; spermatogenesis [GO:0007283]; sulfate transport [GO:0008272]" GO:0000281; GO:0000915; GO:0001669; GO:0005096; GO:0005547; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005874; GO:0006890; GO:0007018; GO:0007283; GO:0007405; GO:0008017; GO:0008272; GO:0009790; GO:0019886; GO:0019901; GO:0030496; GO:0031234; GO:0032154; GO:0032467; GO:0035556; GO:0043014; GO:0043015; GO:0046872; GO:0048487; GO:0051056; GO:0051233; GO:0051256; GO:0051988; GO:0070062; GO:0072686; GO:0097149 0 0 0 PF00130;PF00620; Q9H3F6 CHOYP_PHUM_PHUM024100.1.1 m.8050 sp BACD3_HUMAN 72.285 267 66 5 8 270 22 284 3.68E-138 395 BACD3_HUMAN reviewed BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10) KCTD10 ULR061 MSTP028 Homo sapiens (Human) 313 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567] GO:0005654; GO:0005737; GO:0016567; GO:0031463; GO:0043161; GO:0051260 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02214; Q9Z0H7 CHOYP_LOC100369110.1.1 m.57291 sp BCL10_MOUSE 40.426 94 55 1 9 102 10 102 3.68E-13 68.2 BCL10_MOUSE reviewed B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (mCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (mCIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) Bcl10 Ciper Clap Mus musculus (Mouse) 233 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; adaptive immune response [GO:0002250]; B cell apoptotic process [GO:0001783]; cell death [GO:0008219]; cellular defense response [GO:0006968]; cellular response to mechanical stimulus [GO:0071260]; Fc-epsilon receptor signaling pathway [GO:0038095]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; mast cell activation [GO:0045576]; negative regulation of mature B cell apoptotic process [GO:0002906]; neural tube closure [GO:0001843]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-8 biosynthetic process [GO:0045416]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell activation [GO:0050870]; positive regulation of transcription, DNA-templated [GO:0045893]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; protein oligomerization [GO:0051259]; regulation of T cell receptor signaling pathway [GO:0050856]; response to food [GO:0032094]; response to fungus [GO:0009620]; response to molecule of bacterial origin [GO:0002237]; T cell apoptotic process [GO:0070231]; T cell receptor signaling pathway [GO:0050852]" GO:0001772; GO:0001783; GO:0001843; GO:0002020; GO:0002237; GO:0002250; GO:0002906; GO:0003713; GO:0005634; GO:0005737; GO:0005764; GO:0005829; GO:0005881; GO:0006919; GO:0006968; GO:0007249; GO:0008022; GO:0008134; GO:0008219; GO:0008656; GO:0009620; GO:0016064; GO:0019209; GO:0019899; GO:0019900; GO:0019901; GO:0031398; GO:0031625; GO:0032094; GO:0038095; GO:0042101; GO:0042327; GO:0042803; GO:0043065; GO:0043123; GO:0043130; GO:0043234; GO:0043280; GO:0043422; GO:0043621; GO:0045087; GO:0045121; GO:0045416; GO:0045576; GO:0045893; GO:0046696; GO:0046982; GO:0048471; GO:0050852; GO:0050856; GO:0050870; GO:0051059; GO:0051092; GO:0051259; GO:0051260; GO:0051291; GO:0070231; GO:0071260; GO:1900119; GO:2001238 0 0 0 PF00619; E9PVX6 CHOYP_LOC100371881.2.2 m.12634 sp KI67_MOUSE 49.091 110 56 0 5 114 6 115 3.69E-29 131 KI67_MOUSE reviewed Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67 homolog) (Antigen KI-67 homolog) (Antigen Ki67 homolog) Mki67 Mus musculus (Mouse) 3177 cell proliferation [GO:0008283]; cellular response to heat [GO:0034605]; cholangiocyte proliferation [GO:1990705]; DNA metabolic process [GO:0006259]; hepatocyte proliferation [GO:0072574]; hyaluronan metabolic process [GO:0030212]; meiotic nuclear division [GO:0007126]; organ regeneration [GO:0031100]; response to organic cyclic compound [GO:0014070] GO:0000775; GO:0000793; GO:0005634; GO:0005730; GO:0005737; GO:0006259; GO:0007126; GO:0008022; GO:0008283; GO:0014070; GO:0016020; GO:0030212; GO:0031100; GO:0034605; GO:0044822; GO:0072574; GO:1990705 0 0 0 PF00498;PF08065;PF15276; O75382 CHOYP_BRAFLDRAFT_88217.2.14 m.3558 sp TRIM3_HUMAN 24.891 229 139 10 341 554 534 744 3.69E-10 66.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02595 CHOYP_CALM.49.50 m.63320 sp CALM_PATSP 35 140 88 2 32 169 8 146 3.69E-17 77 CALM_PATSP reviewed Calmodulin (CaM) 0 Patinopecten sp. (Scallop) 149 0 GO:0005509 0 0 0 PF13499; P08761 CHOYP_PHUM_PHUM280830.1.1 m.18608 sp MSRA_DROME 43.519 108 60 1 2 108 125 232 3.69E-19 82.4 MSRA_DROME reviewed Peptide methionine sulfoxide reductase (EC 1.8.4.11) (Ecdysone-induced protein 28/29 kDa) (Methionine-S-sulfoxide reductase) (Peptide-methionine (S)-S-oxide reductase) Eip71CD Eip28/29 MsrA CG7266 Drosophila melanogaster (Fruit fly) 246 autophagic cell death [GO:0048102]; cellular response to oxidative stress [GO:0034599]; determination of adult lifespan [GO:0008340]; neuron projection morphogenesis [GO:0048812]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]; salivary gland cell autophagic cell death [GO:0035071]; sulfur amino acid metabolic process [GO:0000096] GO:0000096; GO:0006979; GO:0008113; GO:0008340; GO:0030091; GO:0034599; GO:0035071; GO:0048102; GO:0048812 0 0 0 PF01625; P16157 CHOYP_TVAG_020440.4.21 m.13643 sp ANK1_HUMAN 35.714 406 259 1 2 405 184 589 3.69E-67 236 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P21328 CHOYP_LOC100561123.8.28 m.10855 sp RTJK_DROME 27.007 411 276 9 199 600 437 832 3.69E-32 138 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P27074 CHOYP_RPL36A.1.1 m.24725 sp RL44Q_CANMA 67.308 104 33 1 1 103 3 106 3.69E-45 145 RL44Q_CANMA reviewed 60S ribosomal protein L44 Q (L41) (L41 Q-type) RIM-C L41Q1A Candida maltosa (Yeast) 106 response to antibiotic [GO:0046677]; response to cycloheximide [GO:0046898]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046677; GO:0046898 0 0 0 PF00935; P53567 CHOYP_LOC100073409.2.2 m.37646 sp CEBPG_HUMAN 55.814 86 38 0 2 87 58 143 3.69E-27 100 CEBPG_HUMAN reviewed CCAAT/enhancer-binding protein gamma (C/EBP gamma) CEBPG Homo sapiens (Human) 150 B cell differentiation [GO:0030183]; enucleate erythrocyte differentiation [GO:0043353]; immune response [GO:0006955]; liver development [GO:0001889]; mRNA metabolic process [GO:0016071]; natural killer cell mediated cytotoxicity [GO:0042267]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA repair [GO:0045739]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0001077; GO:0001889; GO:0003677; GO:0005634; GO:0005654; GO:0006357; GO:0006955; GO:0008134; GO:0016071; GO:0030183; GO:0042267; GO:0043353; GO:0043388; GO:0043433; GO:0043565; GO:0044377; GO:0045078; GO:0045739; GO:0045944; GO:0046982; GO:0051091 0 0 0 PF07716; P61460 CHOYP_AGAP_AGAP002554.1.1 m.59026 sp DEPD5_MOUSE 34.529 223 125 4 1 222 1379 1581 3.69E-38 144 DEPD5_MOUSE reviewed DEP domain-containing protein 5 Depdc5 Kiaa0645 Mus musculus (Mouse) 1591 cellular response to amino acid starvation [GO:0034198]; intracellular signal transduction [GO:0035556]; negative regulation of TORC1 signaling [GO:1904262]; negative regulation of TOR signaling [GO:0032007] GO:0005096; GO:0005764; GO:0005765; GO:0005829; GO:0032007; GO:0032403; GO:0034198; GO:0035556; GO:0048471; GO:1904262; GO:1990130 0 0 0 PF00610;PF12257; Q06852 CHOYP_NEMVEDRAFT_V1G208691.3.10 m.16868 sp SLAP1_CLOTH 49.465 467 108 33 9 416 1388 1785 3.69E-13 75.5 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q12719 CHOYP_LOC100206475.10.16 m.48036 sp LAC4_TRAVE 27.957 558 297 19 57 595 19 490 3.69E-41 160 LAC4_TRAVE reviewed Laccase-4 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 4) (Diphenol oxidase 4) (Urishiol oxidase 4) LCC4 LCC1 Trametes versicolor (White-rot fungus) (Coriolus versicolor) 520 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q27433 CHOYP_MEC2.2.4 m.22810 sp MEC2_CAEEL 69.811 265 76 2 2 262 101 365 3.69E-120 355 MEC2_CAEEL reviewed Mechanosensory protein 2 mec-2 F14D12.4 Caenorhabditis elegans 481 mechanosensory behavior [GO:0007638]; response to mechanical stimulus [GO:0009612] GO:0007638; GO:0009612; GO:0015485; GO:0016021; GO:0032589; GO:0043005 0 0 0 PF01145; Q2VLG6 CHOYP_BRAFLDRAFT_258021.1.1 m.6099 sp C163A_CANLF 52.525 99 44 2 232 329 161 257 3.69E-28 118 C163A_CANLF reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis lupus familiaris (Dog) (Canis familiaris) 1133 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q54KA7 CHOYP_AFUA_1G01020.31.50 m.41126 sp SECG_DICDI 38.941 321 195 1 4 323 168 488 3.69E-57 202 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5R8W8 CHOYP_PTCD3.1.1 m.24655 sp PTCD3_PONAB 24.877 611 370 25 26 586 41 612 3.69E-20 98.6 PTCD3_PONAB reviewed "Pentatricopeptide repeat domain-containing protein 3, mitochondrial (28S ribosomal protein S39, mitochondrial) (MRP-S39)" PTCD3 MRPS39 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 689 mitochondrial translation [GO:0032543]; regulation of translation [GO:0006417] GO:0005739; GO:0006417; GO:0019843; GO:0032543; GO:0043024 0 0 0 PF13041;PF13812; Q5R9R4 CHOYP_BRAFLDRAFT_121562.1.1 m.37268 sp RL7_PONAB 66.805 241 80 0 4 244 6 246 3.69E-112 325 RL7_PONAB reviewed 60S ribosomal protein L7 RPL7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 247 ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0003677; GO:0003729; GO:0005730; GO:0005925; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0070062 0 0 0 PF00327;PF08079; Q5R9R4 CHOYP_LOC100875839.1.1 m.63345 sp RL7_PONAB 66.805 241 80 0 4 244 6 246 3.69E-112 325 RL7_PONAB reviewed 60S ribosomal protein L7 RPL7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 247 ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0003677; GO:0003729; GO:0005730; GO:0005925; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0070062 0 0 0 PF00327;PF08079; Q7TSU7 CHOYP_PHUM_PHUM307810.1.1 m.36470 sp KIRR2_MOUSE 24.39 246 145 8 16 256 1 210 3.69E-07 55.1 KIRR2_MOUSE reviewed Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) Kirrel2 Neph3 Mus musculus (Mouse) 700 negative regulation of protein phosphorylation [GO:0001933]; single organismal cell-cell adhesion [GO:0016337] GO:0001933; GO:0005886; GO:0005911; GO:0016021; GO:0016337; GO:0036057 0 0 0 PF08205;PF07679; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.5.34 m.13666 sp VWDE_HUMAN 26.239 343 228 12 580 910 764 1093 3.69E-18 94 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8R2E9 CHOYP_LOC592215.1.1 m.34856 sp ERO1B_MOUSE 54.566 438 174 7 34 455 34 462 3.69E-168 484 ERO1B_MOUSE reviewed ERO1-like protein beta (ERO1-L-beta) (EC 1.8.4.-) (Endoplasmic reticulum oxidoreductase beta) (Endoplasmic reticulum oxidoreductin-1-like protein B) (Oxidoreductin-1-L-beta) Ero1b Ero1lb Mus musculus (Mouse) 467 4-hydroxyproline metabolic process [GO:0019471]; cell redox homeostasis [GO:0045454]; extracellular matrix organization [GO:0030198]; glucose homeostasis [GO:0042593]; insulin processing [GO:0030070]; protein maturation by protein folding [GO:0022417] GO:0003756; GO:0005789; GO:0015035; GO:0016020; GO:0016671; GO:0019471; GO:0022417; GO:0030070; GO:0030198; GO:0042593; GO:0045454 0 0 0 PF04137; Q8TE57 CHOYP_VM3M1.1.1 m.30243 sp ATS16_HUMAN 28.788 330 187 14 225 551 292 576 3.69E-19 96.3 ATS16_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) ADAMTS16 KIAA2029 Homo sapiens (Human) 1224 branching involved in ureteric bud morphogenesis [GO:0001658]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] GO:0001658; GO:0003073; GO:0004222; GO:0005578; GO:0008270; GO:1902017 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q8VC31 CHOYP_LOC100708024.2.2 m.28481 sp CCDC9_MOUSE 44.737 114 57 2 289 400 186 295 3.69E-19 95.9 CCDC9_MOUSE reviewed Coiled-coil domain-containing protein 9 Ccdc9 Mus musculus (Mouse) 543 0 GO:0044822 0 0 0 PF15266; Q96M20 CHOYP_LOC100893228.5.5 m.52014 sp CNBD2_HUMAN 26.19 294 186 9 154 429 14 294 3.69E-17 89.4 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q96MM6 CHOYP_HSPA12A.14.27 m.39337 sp HS12B_HUMAN 29.777 628 363 20 1101 1659 59 677 3.69E-72 259 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q98943 CHOYP_TRIADDRAFT_62397.1.1 m.65618 sp CASP2_CHICK 31.481 108 74 0 932 1039 3 110 3.69E-07 57.8 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9R1R2 CHOYP_BRAFLDRAFT_87313.1.1 m.32557 sp TRIM3_MOUSE 23.704 135 88 3 138 270 622 743 3.69E-06 52 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; V5YMB3 CHOYP_BRAFLDRAFT_121562.1.1 m.37267 sp DAPB3_PSEMX 30.992 242 160 4 424 658 391 632 3.69E-24 111 DAPB3_PSEMX reviewed Dipeptidyl aminopeptidase BIII (DAP BIII) (EC 3.4.14.-) dapb3 Pseudoxanthomonas mexicana 689 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004175; GO:0008236; GO:0008239; GO:0051603 0 0 0 PF00326; A7SLZ2 CHOYP_NEMVEDRAFT_V1G246111.1.2 m.45249 sp STING_NEMVE 27.66 282 157 13 86 344 113 370 3.70E-14 78.2 STING_NEMVE reviewed Stimulator of interferon genes protein (STING) v1g246111 Nematostella vectensis (Starlet sea anemone) 377 activation of innate immune response [GO:0002218]; positive regulation of type I interferon production [GO:0032481] GO:0002218; GO:0005789; GO:0016021; GO:0032481; GO:0035438; GO:0061507 0 0 0 PF15009; O02703 CHOYP_BAX.1.1 m.30787 sp BAX_BOVIN 39.037 187 101 5 69 252 15 191 3.70E-37 132 BAX_BOVIN reviewed Apoptosis regulator BAX BAX Bos taurus (Bovine) 192 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; apoptotic process involved in patterning of blood vessels [GO:1902262]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell homeostatic proliferation [GO:0002358]; B cell negative selection [GO:0002352]; B cell receptor apoptotic signaling pathway [GO:1990117]; blood vessel remodeling [GO:0001974]; cellular response to organic substance [GO:0071310]; cellular response to UV [GO:0034644]; cerebral cortex development [GO:0021987]; development of secondary sexual characteristics [GO:0045136]; ectopic germ cell programmed cell death [GO:0035234]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; fertilization [GO:0009566]; germ cell development [GO:0007281]; glycosphingolipid metabolic process [GO:0006687]; homeostasis of number of cells within a tissue [GO:0048873]; hypothalamus development [GO:0021854]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial fusion [GO:0008053]; mitochondrion morphogenesis [GO:0070584]; myeloid cell homeostasis [GO:0002262]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein binding [GO:0032091]; neuron apoptotic process [GO:0051402]; neuron migration [GO:0001764]; odontogenesis of dentin-containing tooth [GO:0042475]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of developmental pigmentation [GO:0048087]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; post-embryonic camera-type eye morphogenesis [GO:0048597]; protein homooligomerization [GO:0051260]; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844]; regulation of cell cycle [GO:0051726]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of nitrogen utilization [GO:0006808]; regulation of protein heterodimerization activity [GO:0043497]; regulation of protein homodimerization activity [GO:0043496]; release of cytochrome c from mitochondria [GO:0001836]; release of matrix enzymes from mitochondria [GO:0032976]; response to axon injury [GO:0048678]; response to gamma radiation [GO:0010332]; response to salt stress [GO:0009651]; response to toxic substance [GO:0009636]; retina development in camera-type eye [GO:0060041]; retinal cell apoptotic process [GO:1990009]; retinal cell programmed cell death [GO:0046666]; Sertoli cell proliferation [GO:0060011]; spermatid differentiation [GO:0048515]; T cell homeostatic proliferation [GO:0001777]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068] GO:0001541; GO:0001764; GO:0001777; GO:0001782; GO:0001783; GO:0001822; GO:0001836; GO:0001844; GO:0001974; GO:0002262; GO:0002352; GO:0002358; GO:0002904; GO:0005634; GO:0005635; GO:0005739; GO:0005741; GO:0005757; GO:0005783; GO:0005789; GO:0005829; GO:0006687; GO:0006808; GO:0006919; GO:0007281; GO:0008053; GO:0008289; GO:0008625; GO:0008630; GO:0008635; GO:0008637; GO:0009566; GO:0009636; GO:0009651; GO:0010248; GO:0010332; GO:0015267; GO:0021854; GO:0021987; GO:0032091; GO:0032461; GO:0032471; GO:0032976; GO:0033137; GO:0033599; GO:0034644; GO:0035234; GO:0042475; GO:0042803; GO:0043065; GO:0043496; GO:0043497; GO:0043524; GO:0043525; GO:0043653; GO:0045136; GO:0046666; GO:0046930; GO:0046982; GO:0048087; GO:0048147; GO:0048515; GO:0048597; GO:0048678; GO:0048873; GO:0051260; GO:0051281; GO:0051402; GO:0051434; GO:0051726; GO:0051881; GO:0060011; GO:0060041; GO:0060058; GO:0060068; GO:0070059; GO:0070062; GO:0070242; GO:0070584; GO:0071310; GO:0072332; GO:0090200; GO:0097136; GO:0097144; GO:0097190; GO:0097192; GO:0097193; GO:0097296; GO:1900103; GO:1902262; GO:1902263; GO:1902445; GO:1902512; GO:1990009; GO:1990117; GO:2001234; GO:2001241; GO:2001244 0 0 0 PF00452; O34355 CHOYP_contig_037000 m.41674 sp YTCJ_BACSU 25.483 569 356 21 61 605 2 526 3.70E-36 145 YTCJ_BACSU reviewed Putative amidohydrolase YtcJ (EC 3.5.-.-) ytcJ BSU29550 Bacillus subtilis (strain 168) 529 0 GO:0016810 0 0 0 PF07969; O70277 CHOYP_BRAFLDRAFT_169578.1.2 m.39245 sp TRIM3_RAT 27.419 124 87 2 134 254 620 743 3.70E-08 57.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88279 CHOYP_BRAFLDRAFT_69264.6.6 m.66882 sp SLIT1_RAT 31.955 266 129 6 29 259 29 277 3.70E-29 122 SLIT1_RAT reviewed Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) 1531 brain development [GO:0007420]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510] GO:0005509; GO:0005578; GO:0005615; GO:0007420; GO:0008201; GO:0021510; GO:0035385; GO:0043395; GO:0048495; GO:0048843; GO:0051964 0 0 0 PF00008;PF12661;PF02210;PF13855;PF01463;PF01462; P04323 CHOYP_LOC578054.6.7 m.65022 sp POL3_DROME 41.553 438 241 7 794 1223 193 623 3.70E-95 332 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P0CB96 CHOYP_NEMVEDRAFT_V1G180651.1.2 m.2809 sp NDUS4_PONPY 69.291 127 39 0 43 169 49 175 3.70E-63 195 NDUS4_PONPY reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit)" NDUFS4 Pongo pygmaeus (Bornean orangutan) 175 brain development [GO:0007420]; cAMP-mediated signaling [GO:0019933]; cellular respiration [GO:0045333]; electron transport chain [GO:0022900]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of fibroblast proliferation [GO:0048146]; reactive oxygen species metabolic process [GO:0072593]; response to cAMP [GO:0051591] GO:0005747; GO:0007420; GO:0016651; GO:0019933; GO:0022900; GO:0032981; GO:0045333; GO:0048146; GO:0051591; GO:0072593 0 0 0 PF04800; P21783 CHOYP_LOC100378430.1.1 m.63142 sp NOTC1_XENLA 36.019 422 197 18 694 1074 591 980 3.70E-54 212 NOTC1_XENLA reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (xOTCH) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] notch1 xotch Xenopus laevis (African clawed frog) 2524 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001525; GO:0004872; GO:0005509; GO:0005654; GO:0005886; GO:0006351; GO:0016021; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P23469 CHOYP_BM1_22505.1.1 m.13356 sp PTPRE_HUMAN 37.879 66 41 0 28 93 624 689 3.70E-10 58.5 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P32577 CHOYP_BRAFLDRAFT_81321.6.10 m.48025 sp CSK_RAT 28.188 298 160 10 723 1015 195 443 3.70E-22 104 CSK_RAT reviewed Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) Csk Rattus norvegicus (Rat) 450 adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; brain development [GO:0007420]; cell migration [GO:0016477]; cellular response to peptide hormone stimulus [GO:0071375]; innate immune response [GO:0045087]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of kinase activity [GO:0033673]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of MAP kinase activity [GO:0043406]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0002250; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005737; GO:0005911; GO:0006468; GO:0007169; GO:0007420; GO:0008285; GO:0010989; GO:0016477; GO:0019903; GO:0031234; GO:0032715; GO:0033673; GO:0034332; GO:0038083; GO:0042997; GO:0043406; GO:0045087; GO:0045121; GO:0045779; GO:0046777; GO:0046872; GO:0048709; GO:0050765; GO:0060368; GO:0070062; GO:0070064; GO:0070373; GO:0071375 0 0 0 PF07714;PF00017;PF00018; P79345 CHOYP_NPC2.2.7 m.29742 sp NPC2_BOVIN 37.415 147 90 2 5 150 4 149 3.70E-32 114 NPC2_BOVIN reviewed Epididymal secretory protein E1 (EPV20) (Niemann Pick type C2 protein homolog) NPC2 Bos taurus (Bovine) 149 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; response to virus [GO:0009615] GO:0005764; GO:0005783; GO:0008203; GO:0009615; GO:0015485; GO:0030301; GO:0032367; GO:0033344; GO:0042632; GO:0070062 0 0 0 PF02221; Q04870 CHOYP_LOC661787.1.1 m.15775 sp T2FA_XENLA 48.333 180 85 4 11 188 5 178 3.70E-51 175 T2FA_XENLA reviewed General transcription factor IIF subunit 1 (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) gtf2f1 rap74 Xenopus laevis (African clawed frog) 524 positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; transcription initiation from RNA polymerase II promoter [GO:0006367] GO:0003677; GO:0005634; GO:0006367; GO:0016740; GO:0032968 0 0 0 PF05793; Q06649 CHOYP_3BP2.2.3 m.19302 sp 3BP2_MOUSE 36.22 127 77 3 3 127 5 129 3.70E-19 93.2 3BP2_MOUSE reviewed SH3 domain-binding protein 2 (3BP-2) Sh3bp2 3bp2 Mus musculus (Mouse) 559 0 GO:0017124 0 0 0 PF00169;PF00017; Q06852 CHOYP_contig_023326 m.26539 sp SLAP1_CLOTH 27.069 447 251 16 24 417 1232 1656 3.70E-10 66.2 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0VAA2 CHOYP_BRAFLDRAFT_66304.2.3 m.28211 sp LR74A_HUMAN 33.249 397 253 5 115 506 83 472 3.70E-61 217 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q0VBY7 CHOYP_BRAFLDRAFT_90371.1.1 m.1046 sp DJC24_BOVIN 34.286 140 86 3 27 165 12 146 3.70E-21 87 DJC24_BOVIN reviewed DnaJ homolog subfamily C member 24 (CSL-type zinc finger-containing protein 3) (Diphthamide biosynthesis protein 4) DNAJC24 DPH4 ZCSL3 Bos taurus (Bovine) 148 oxidation-reduction process [GO:0055114]; peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183]; positive regulation of ATPase activity [GO:0032781] GO:0001671; GO:0005737; GO:0005856; GO:0008198; GO:0008270; GO:0017183; GO:0032781; GO:0055114 PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. 0 cd06257; PF00226;PF05207; Q17031 CHOYP_CDC42.10.11 m.59264 sp CDC42_ANOGA 33.511 188 108 3 7 177 3 190 3.70E-28 107 CDC42_ANOGA reviewed Cdc42 homolog (25 kDa GTP-binding protein) Cdc42 AGAP002440 Anopheles gambiae (African malaria mosquito) 191 multicellular organism development [GO:0007275]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275 0 0 0 PF00071; Q502K3 CHOYP_TVAG_080420.2.2 m.61341 sp ANR52_DANRE 26.389 288 190 9 1 273 156 436 3.70E-10 66.2 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q5RC32 CHOYP_MDM1.2.2 m.49505 sp MDM1_PONAB 27.358 636 358 25 236 842 162 722 3.70E-31 134 MDM1_PONAB reviewed Nuclear protein MDM1 MDM1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 724 negative regulation of centriole replication [GO:0046600] GO:0005634; GO:0005813; GO:0005814; GO:0005874; GO:0008017; GO:0046600 0 0 0 PF15501; Q5RH71 CHOYP_LOC100162380.1.1 m.23942 sp TSN33_DANRE 34.155 284 165 8 2 280 7 273 3.70E-49 167 TSN33_DANRE reviewed Tetraspanin-33 (Tspan-33) tspan33 zgc:92266 Danio rerio (Zebrafish) (Brachydanio rerio) 281 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747] GO:0005887; GO:0007166; GO:0045747; GO:0090002 0 0 0 PF00335; Q6E2N3 CHOYP_BRAFLDRAFT_67269.3.4 m.37159 sp TRI33_DANRE 26.609 233 129 10 14 215 220 441 3.70E-06 53.1 TRI33_DANRE reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Protein moonshine) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 mon Danio rerio (Zebrafish) (Brachydanio rerio) 1163 "embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; fin development [GO:0033333]; post-embryonic hemopoiesis [GO:0035166]; primitive hemopoiesis [GO:0060215]; protein ubiquitination [GO:0016567]; regulation of transcription elongation from RNA polymerase II promoter [GO:0034243]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0030218; GO:0033333; GO:0034243; GO:0035162; GO:0035166; GO:0060215 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643; Q8AV57 CHOYP_LOC100900162.1.1 m.58237 sp SDK2_CHICK 26.879 346 215 14 387 722 590 907 3.70E-14 80.5 SDK2_CHICK reviewed Protein sidekick-2 SDK2 Gallus gallus (Chicken) 2177 camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0016021; GO:0030054; GO:0042802; GO:0045202; GO:0060219 0 0 0 PF00041;PF07679; Q8CGF7 CHOYP_TCERG1.1.1 m.32200 sp TCRG1_MOUSE 44.656 262 98 5 203 434 434 678 3.70E-48 181 TCRG1_MOUSE reviewed Transcription elongation regulator 1 (Formin-binding protein 28) (FBP 28) (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) (p144) Tcerg1 Taf2s Mus musculus (Mouse) 1100 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001103; GO:0001106; GO:0003700; GO:0005634; GO:0005730; GO:0006351; GO:0015629; GO:0044822; GO:0070064 0 0 0 PF01846;PF00397; Q95M17 CHOYP_BRAFLDRAFT_281651.4.8 m.19363 sp CHIA_BOVIN 50.485 412 181 8 1 400 1 401 3.70E-140 412 CHIA_BOVIN reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Chitin-binding protein b04) (CBPb04) CHIA Bos taurus (Bovine) 472 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532] GO:0000272; GO:0002376; GO:0002532; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0006032; GO:0006915; GO:0008061; GO:0090197 0 0 0 PF01607;PF00704; Q9I8C7 CHOYP_ACHA.2.2 m.36115 sp ACH10_CHICK 32.012 328 208 7 17 335 20 341 3.70E-48 173 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9I8C7 CHOYP_SMP_157790.1.1 m.34513 sp ACH10_CHICK 33.647 425 256 10 59 481 48 448 3.70E-83 267 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9JKR5 CHOYP_BRAFLDRAFT_117158.2.2 m.42430 sp ZDHC2_RAT 49.558 339 161 3 253 586 16 349 3.70E-122 368 ZDHC2_RAT reviewed Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) Zdhhc2 Srec Rattus norvegicus (Rat) 366 protein palmitoylation [GO:0018345] GO:0005783; GO:0005794; GO:0005887; GO:0008270; GO:0018345; GO:0019706; GO:0055038 0 0 0 PF01529; Q9VCA8 CHOYP_LOC100641396.23.27 m.60247 sp ANKHM_DROME 36.458 192 111 7 839 1021 622 811 3.70E-18 94.7 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9Y1A3 CHOYP_NEMVEDRAFT_V1G154974.1.1 m.44261 sp TIM8_DROME 40 70 42 0 33 102 11 80 3.70E-16 70.5 TIM8_DROME reviewed Mitochondrial import inner membrane translocase subunit Tim8 Tim8 CG1728 Drosophila melanogaster (Fruit fly) 88 protein transport [GO:0015031] GO:0005739; GO:0005743; GO:0015031; GO:0046872 0 0 0 PF02953; B3EWZ6 CHOYP_C163A.2.2 m.50512 sp MLRP2_ACRMI 33.043 115 65 4 58 161 1922 2035 3.71E-06 49.7 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B5DFC9 CHOYP_NEMVEDRAFT_V1G119340.1.1 m.58197 sp NID2_RAT 39.161 143 78 4 67 202 786 926 3.71E-26 108 NID2_RAT reviewed Nidogen-2 (NID-2) Nid2 Rattus norvegicus (Rat) 1396 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005604; GO:0007160; GO:0009986 0 0 0 PF07645;PF07474;PF00058;PF06119;PF00086; D3YXG0 CHOYP_LOC101236385.1.6 m.1157 sp HMCN1_MOUSE 46.199 342 184 0 144 485 4527 4868 3.71E-95 325 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; H2A0N4 CHOYP_contig_007981 m.9238 sp PIF_PINMG 29.022 317 180 9 1676 1962 238 539 3.71E-33 144 PIF_PINMG reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada margaritifera (Black-lipped pearl oyster) 1014 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607;PF00092; O42387 CHOYP_RPS24.4.8 m.21308 sp RS24_TAKRU 82.4 125 22 0 7 131 6 130 3.71E-72 216 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O46606 CHOYP_DDHD1.1.1 m.53492 sp DDHD1_BOVIN 40.028 727 326 15 70 703 156 865 3.71E-166 503 DDHD1_BOVIN reviewed Phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1) (PA-PLA1) DDHD1 Bos taurus (Bovine) 875 lipid catabolic process [GO:0016042] GO:0004620; GO:0005737; GO:0016042; GO:0046872 0 0 0 PF02862; O70277 CHOYP_BRAFLDRAFT_69765.19.23 m.60489 sp TRIM3_RAT 26.316 228 129 12 2 211 536 742 3.71E-10 62.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC100368547.37.40 m.59598 sp TRIM3_RAT 26.712 146 103 3 43 185 599 743 3.71E-10 62.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88822 CHOYP_NEMVEDRAFT_V1G203546.1.1 m.37553 sp SC5D_MOUSE 28.662 157 96 3 166 306 100 256 3.71E-09 60.5 SC5D_MOUSE reviewed Lathosterol oxidase (EC 1.14.19.20) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Delta(7)-sterol C5(6)-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase) Sc5d Sc5dl Mus musculus (Mouse) 299 cholesterol biosynthetic process via lathosterol [GO:0033490]; fatty acid biosynthetic process [GO:0006633] GO:0000248; GO:0005506; GO:0005789; GO:0006633; GO:0016021; GO:0033490 0 0 0 PF04116; P05099 CHOYP_BRAFLDRAFT_126487.1.2 m.5650 sp MATN1_CHICK 35.374 147 85 4 277 418 39 180 3.71E-19 93.2 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P0DJG4 CHOYP_NEMVEDRAFT_V1G160170.1.1 m.66042 sp THEGL_HUMAN 29.97 337 190 10 51 374 162 465 3.71E-27 115 THEGL_HUMAN reviewed Testicular haploid expressed gene protein-like (Theg spermatid-like protein) THEGL Homo sapiens (Human) 465 0 0 0 0 0 PF14912; P22105 CHOYP_MEGF6.18.59 m.26111 sp TENX_HUMAN 31.028 535 281 46 180 672 263 751 3.71E-36 150 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P27674 CHOYP_GTR1.1.1 m.25509 sp GTR1_BOVIN 37.008 508 269 6 23 526 22 482 3.71E-111 342 GTR1_BOVIN reviewed "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)" SLC2A1 GLUT-I GLUT1 Bos taurus (Bovine) 492 cellular response to glucose starvation [GO:0042149]; glucose import [GO:0046323]; glucose transport [GO:0015758]; protein complex assembly [GO:0006461] GO:0001939; GO:0005355; GO:0005829; GO:0005887; GO:0006461; GO:0015758; GO:0016323; GO:0016324; GO:0030496; GO:0030864; GO:0033300; GO:0042149; GO:0042470; GO:0043621; GO:0045121; GO:0046323; GO:0055056; GO:0070062; GO:0072562 0 0 cd06174; PF00083; P35555 CHOYP_contig_026700 m.30399 sp FBN1_HUMAN 32.104 922 490 40 1372 2206 1766 2638 3.71E-87 323 FBN1_HUMAN reviewed Fibrillin-1 [Cleaved into: Asprosin] FBN1 FBN Homo sapiens (Human) 2871 activation of protein kinase A activity [GO:0034199]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; protein kinase A signaling [GO:0010737]; regulation of cellular response to growth factor stimulus [GO:0090287]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501] GO:0001501; GO:0001527; GO:0001656; GO:0005178; GO:0005179; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0005604; GO:0005615; GO:0005622; GO:0006006; GO:0007507; GO:0008201; GO:0010737; GO:0022617; GO:0030023; GO:0030198; GO:0031012; GO:0032403; GO:0033627; GO:0034199; GO:0035582; GO:0035583; GO:0042593; GO:0043010; GO:0045671; GO:0048048; GO:0048050; GO:0070062; GO:0071560; GO:0090287; GO:1990314; GO:2001205 0 0 0 PF12662;PF07645;PF00683; P51968 CHOYP_PININ.1.1 m.56668 sp RO31_XENLA 59.091 110 43 1 16 125 15 122 3.71E-39 138 RO31_XENLA reviewed Heterogeneous nuclear ribonucleoprotein A3 homolog 1 (hnRNP A3(A)) 0 Xenopus laevis (African clawed frog) 373 0 GO:0000166; GO:0003723; GO:0005634; GO:0030529 0 0 0 PF00076; P54360 CHOYP_PHUM_PHUM596540.1.1 m.36688 sp FOJO_DROME 35.657 502 233 14 13 429 85 581 3.71E-89 285 FOJO_DROME reviewed "Extracellular serine/threonine protein kinase four-jointed (EC 2.7.11.1) [Cleaved into: Protein four-jointed, secreted isoform]" fj CG10917 Drosophila melanogaster (Fruit fly) 583 "cell-cell signaling [GO:0007267]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; Notch signaling pathway [GO:0007219]; protein phosphorylation [GO:0006468]; regulation of imaginal disc-derived wing size [GO:0044719]; regulation of protein binding [GO:0043393]; regulation of tube length, open tracheal system [GO:0035159]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000139; GO:0001736; GO:0001737; GO:0004672; GO:0004674; GO:0005615; GO:0005886; GO:0006468; GO:0007219; GO:0007267; GO:0007446; GO:0007474; GO:0016021; GO:0016348; GO:0017147; GO:0035159; GO:0042067; GO:0043393; GO:0044719; GO:0045198; GO:0060071 0 0 0 0 Q0DV28 CHOYP_BRAFLDRAFT_130981.2.3 m.12452 sp ARK1_ORYSJ 28.814 177 108 6 223 390 692 859 3.71E-06 53.5 ARK1_ORYSJ reviewed Armadillo repeat-containing kinesin-like protein 1 Os03g0152900 LOC_Os03g05820 Oryza sativa subsp. japonica (Rice) 945 cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; protein localization [GO:0008104]; regulation of microtubule-based process [GO:0032886]; root development [GO:0048364] GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0008104; GO:0008574; GO:0030705; GO:0032886; GO:0048364 0 0 0 PF00514;PF00225; Q16G71 CHOYP_LOC100647975.1.2 m.6945 sp MED10_AEDAE 69.231 130 39 1 15 144 2 130 3.71E-62 189 MED10_AEDAE reviewed Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) MED10 AAEL014501 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 130 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592 0 0 0 PF09748; Q26473 CHOYP_SEM1A.1.2 m.57703 sp SEM1A_SCHAM 41.329 692 332 21 25 693 18 658 3.71E-165 498 SEM1A_SCHAM reviewed Semaphorin-1A (Fasciclin IV) (Fasciclin-4) (Semaphorin-I) (Sema I) SEMA-1A FAS4 Schistocerca americana (American grasshopper) 730 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0007399; GO:0016021; GO:0030154 0 0 0 PF01403; Q58EX2 CHOYP_LOC100368802.1.1 m.46372 sp SDK2_HUMAN 30.457 197 120 9 51 246 367 547 3.71E-07 54.3 SDK2_HUMAN reviewed Protein sidekick-2 SDK2 KIAA1514 Homo sapiens (Human) 2172 camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0016021; GO:0030054; GO:0045202; GO:0060219 0 0 0 PF00041;PF07679; Q6ZRF8 CHOYP_LOC100374981.2.16 m.24353 sp RN207_HUMAN 32.353 102 62 5 16 115 103 199 3.71E-07 50.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q99MU3 CHOYP_DSRAD.3.4 m.24850 sp DSRAD_MOUSE 26.185 401 224 8 95 433 455 845 3.71E-19 94 DSRAD_MOUSE reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (RNA adenosine deaminase 1) Adar Mus musculus (Mouse) 1178 "adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; regulation of transcription, DNA-templated [GO:0006355]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; transcription, DNA-templated [GO:0006351]" GO:0001649; GO:0001701; GO:0002244; GO:0002566; GO:0003692; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0006382; GO:0006397; GO:0006606; GO:0006611; GO:0009615; GO:0016020; GO:0016553; GO:0030218; GO:0031054; GO:0035196; GO:0035280; GO:0035455; GO:0043066; GO:0044387; GO:0044530; GO:0044822; GO:0045070; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060216; GO:0060339; GO:0061484; GO:0098586; GO:1900369 0 0 0 PF02137;PF00035;PF02295; Q9NRY5 CHOYP_LOC100370330.1.1 m.10944 sp F1142_HUMAN 30.085 472 245 10 256 706 82 489 3.71E-58 208 F1142_HUMAN reviewed Protein FAM114A2 FAM114A2 C5orf3 Homo sapiens (Human) 505 0 GO:0017076 0 0 0 PF05334; Q9V818 CHOYP_PHUM_PHUM300610.2.5 m.25440 sp MTH3_DROME 29.181 281 178 8 175 436 219 497 3.71E-20 96.3 MTH3_DROME reviewed Probable G-protein coupled receptor Mth-like 3 (Protein methuselah-like 3) mthl3 BEST:GM02553 CG6530 Drosophila melanogaster (Fruit fly) 511 cell surface receptor signaling pathway [GO:0007166]; determination of adult lifespan [GO:0008340]; G-protein coupled receptor signaling pathway [GO:0007186]; response to starvation [GO:0042594] GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0008340; GO:0016021; GO:0042594 0 0 0 PF00002;PF06652; Q9XTA0 CHOYP_ACDOPBH.2.9 m.9399 sp DOPO_HORSE 31.288 326 209 9 151 464 203 525 3.71E-41 161 DOPO_HORSE reviewed Dopamine beta-hydroxylase (EC 1.14.17.1) [Cleaved into: Soluble dopamine beta-hydroxylase] DBH Equus caballus (Horse) 610 dopamine catabolic process [GO:0042420]; norepinephrine biosynthetic process [GO:0042421] GO:0004500; GO:0005507; GO:0005615; GO:0016021; GO:0030658; GO:0030667; GO:0031418; GO:0034466; GO:0034774; GO:0042420; GO:0042421; GO:0042584 PATHWAY: Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. {ECO:0000250|UniProtKB:P09172}. 0 0 PF03712;PF01082;PF03351; A5D7L5 CHOYP_S39AE.3.3 m.51422 sp S39AE_BOVIN 35.835 533 278 16 9 530 11 490 3.72E-100 313 S39AE_BOVIN reviewed Zinc transporter ZIP14 (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14) SLC39A14 ZIP14 Bos taurus (Bovine) 490 cellular zinc ion homeostasis [GO:0006882]; zinc II ion transmembrane import [GO:0071578]; zinc II ion transmembrane transport [GO:0071577] GO:0005385; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0006882; GO:0015093; GO:0071577; GO:0071578 0 0 0 PF02535; O15990 CHOYP_KARG.7.11 m.16762 sp KARG_LIOJA 62.791 129 48 0 1 129 142 270 3.72E-53 174 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O43301 CHOYP_BRAFLDRAFT_57788.1.10 m.23715 sp HS12A_HUMAN 31.266 403 219 9 2 354 128 522 3.72E-60 208 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P13216 CHOYP_DANA_GF25062.1.1 m.5948 sp ADX_CHICK 54.264 129 49 3 6 125 8 135 3.72E-41 136 ADX_CHICK reviewed "Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Fragment)" FDX1 Gallus gallus (Chicken) 143 cholesterol metabolic process [GO:0008203]; hormone biosynthetic process [GO:0042446]; oxidation-reduction process [GO:0055114]; steroid biosynthetic process [GO:0006694] GO:0005759; GO:0006694; GO:0008203; GO:0009055; GO:0042446; GO:0046872; GO:0051537; GO:0055114 0 0 cd00207; PF00111; P97571 CHOYP_LOC101072210.1.1 m.27381 sp CAN1_RAT 27.103 428 258 14 87 479 106 514 3.72E-40 160 CAN1_RAT reviewed Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Micromolar-calpain) (muCANP) Capn1 Cls1 Rattus norvegicus (Rat) 713 protein autoprocessing [GO:0016540]; proteolysis [GO:0006508] GO:0004198; GO:0005509; GO:0005737; GO:0005886; GO:0006508; GO:0008092; GO:0016540 0 0 0 PF01067;PF13833;PF00648; Q09225 CHOYP_LOC100368914.2.3 m.27417 sp NRF6_CAEEL 28.685 631 346 20 112 675 153 746 3.72E-71 250 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q0IHI6 CHOYP_LOC100122530.1.1 m.15161 sp MED30_XENLA 35.802 162 93 5 75 230 27 183 3.72E-26 103 MED30_XENLA reviewed Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) med30 Xenopus laevis (African clawed frog) 184 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11315; Q0IHI6 CHOYP_contig_032576 m.37193 sp MED30_XENLA 35.802 162 93 5 75 230 27 183 3.72E-26 103 MED30_XENLA reviewed Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) med30 Xenopus laevis (African clawed frog) 184 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11315; Q24K15 CHOYP_BRAFLDRAFT_86061.13.13 m.64745 sp ANGP4_BOVIN 41.256 223 120 6 171 391 281 494 3.72E-47 171 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q32LJ3 CHOYP_LOC577294.1.1 m.56296 sp CX065_BOVIN 29.677 155 99 3 1 153 1 147 3.72E-09 55.8 CX065_BOVIN reviewed Uncharacterized protein CXorf65 homolog 0 Bos taurus (Bovine) 174 0 0 0 0 0 0 Q4LDE5 CHOYP_LOC663838.1.2 m.40550 sp SVEP1_HUMAN 37.405 131 76 4 2 128 1032 1160 3.72E-12 70.9 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4R7U0 CHOYP_LOC100743792.1.1 m.45867 sp TMC7_MACFA 32.727 770 440 17 35 782 4 717 3.72E-130 407 TMC7_MACFA reviewed Transmembrane channel-like protein 7 TMC7 QtsA-14390 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 723 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q5E9X5 CHOYP_LOC100376250.1.1 m.46061 sp AP5M1_BOVIN 36.701 485 288 9 16 490 1 476 3.72E-103 321 AP5M1_BOVIN reviewed AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5) AP5M1 Bos taurus (Bovine) 490 endosomal transport [GO:0016197]; protein transport [GO:0015031] GO:0005764; GO:0005765; GO:0005770; GO:0005829; GO:0015031; GO:0016020; GO:0016197; GO:0030119; GO:0031902 0 0 0 PF00928; Q5SUE8 CHOYP_ANR40.1.1 m.1429 sp ANR40_MOUSE 52.459 122 49 2 2 115 7 127 3.72E-35 131 ANR40_MOUSE reviewed Ankyrin repeat domain-containing protein 40 Ankrd40 Mus musculus (Mouse) 363 0 0 0 0 0 0 Q6DIB5 CHOYP_MEGF6.45.59 m.47519 sp MEG10_MOUSE 38.217 314 173 14 4 313 160 456 3.72E-43 161 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6P2X9 CHOYP_DPER_GL21167.2.2 m.66320 sp MOT12_XENTR 31.731 208 136 1 29 230 8 215 3.72E-32 129 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q70E20 CHOYP_SNED1.3.4 m.51851 sp SNED1_MOUSE 37.124 598 292 13 25 547 28 616 3.72E-106 373 SNED1_MOUSE reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) 1403 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q80ZX8 CHOYP_LOC100369340.1.1 m.51639 sp SPAG1_MOUSE 44.598 361 180 8 1 348 1 354 3.72E-78 280 SPAG1_MOUSE reviewed Sperm-associated antigen 1 (Infertility-related sperm protein Spag-1) (TPR-containing protein involved in spermatogenesis) (TPIS) Spag1 Tpis Mus musculus (Mouse) 901 axonemal dynein complex assembly [GO:0070286]; single fertilization [GO:0007338] GO:0005525; GO:0005654; GO:0005737; GO:0007338; GO:0015630; GO:0016787; GO:0070286 0 0 0 PF13877;PF00515;PF13181; Q8R3F5 CHOYP_LOC100366955.1.1 m.47686 sp FABD_MOUSE 43.478 345 185 4 53 389 30 372 3.72E-92 284 FABD_MOUSE reviewed "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)" Mcat Mt Mus musculus (Mouse) 381 fatty acid biosynthetic process [GO:0006633] GO:0004314; GO:0005739; GO:0006633; GO:0016740; GO:0044822 PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 PF00698; Q8WQI5 CHOYP_RS8.1.14 m.11955 sp RS8_SPOFR 71.359 206 57 1 14 219 4 207 3.72E-104 302 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q8WU90 CHOYP_ZC3HF.1.1 m.39867 sp ZC3HF_HUMAN 54 400 157 9 25 415 28 409 3.72E-122 364 ZC3HF_HUMAN reviewed Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4) ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730 Homo sapiens (Human) 426 cytokine-mediated signaling pathway [GO:0019221] GO:0005730; GO:0005737; GO:0005913; GO:0019221; GO:0044822; GO:0046872; GO:0098641 0 0 0 PF16543;PF00642; Q90Y54 CHOYP_JAG1.1.3 m.18439 sp JAG1B_DANRE 31.683 202 115 9 30 220 56 245 3.72E-09 61.6 JAG1B_DANRE reviewed Protein jagged-1b (Jagged1b) (Jagged3) jag1b jag3 Danio rerio (Zebrafish) (Brachydanio rerio) 1213 auditory receptor cell development [GO:0060117]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; dorsal/ventral pattern formation [GO:0009953]; face morphogenesis [GO:0060325]; fin regeneration [GO:0031101]; inner ear morphogenesis [GO:0042472]; liver development [GO:0001889]; Notch signaling pathway [GO:0007219]; otolith morphogenesis [GO:0032474]; pancreas development [GO:0031016]; semicircular canal development [GO:0060872]; semicircular canal morphogenesis [GO:0048752]; thyroid gland development [GO:0030878] GO:0001889; GO:0005509; GO:0007219; GO:0009953; GO:0016021; GO:0030878; GO:0031016; GO:0031101; GO:0032474; GO:0042472; GO:0048752; GO:0060117; GO:0060325; GO:0060351; GO:0060872 0 0 0 PF01414;PF00008;PF07645;PF12661;PF07657; Q95LC6 CHOYP_CD209.5.6 m.57343 sp CD209_MACNE 37.5 160 84 8 62 218 212 358 3.72E-20 90.5 CD209_MACNE reviewed CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN1) (CD antigen CD209) CD209 Macaca nemestrina (Pig-tailed macaque) 381 adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; endocytosis [GO:0006897]; innate immune response [GO:0045087] GO:0002250; GO:0005537; GO:0006897; GO:0007155; GO:0016021; GO:0045087; GO:0046872 0 0 0 PF00059; Q96RK0 CHOYP_CIC.2.2 m.58384 sp CIC_HUMAN 36.417 508 195 20 840 1259 30 497 3.72E-60 233 CIC_HUMAN reviewed Protein capicua homolog CIC KIAA0306 Homo sapiens (Human) 1608 "lung alveolus development [GO:0048286]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0048286 0 0 0 PF00505; Q96RW7 CHOYP_BM1_12515.2.7 m.13415 sp HMCN1_HUMAN 23.75 400 263 17 242 631 4019 4386 3.72E-07 58.9 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9CQ66 CHOYP_LOC100180883.1.1 m.46611 sp TC1D2_MOUSE 61.417 127 47 1 4 128 18 144 3.72E-55 172 TC1D2_MOUSE reviewed Tctex1 domain-containing protein 2 Tctex1d2 Mus musculus (Mouse) 144 0 0 0 0 0 PF03645; Q9JIA7 CHOYP_SPHK2.1.2 m.35796 sp SPHK2_MOUSE 31.28 617 377 13 8 601 15 607 3.72E-85 281 SPHK2_MOUSE reviewed Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Sphk2 Mus musculus (Mouse) 617 blood vessel development [GO:0001568]; brain development [GO:0007420]; cell proliferation [GO:0008283]; female pregnancy [GO:0007565]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell proliferation [GO:0008284]; sphinganine-1-phosphate biosynthetic process [GO:0006669]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670] GO:0001568; GO:0005524; GO:0005765; GO:0005829; GO:0006669; GO:0006670; GO:0007420; GO:0007565; GO:0008283; GO:0008284; GO:0008481; GO:0016020; GO:0017050; GO:0038036; GO:0043066; GO:0046512 0 0 0 PF00781; Q9UUH0 CHOYP_BRAFLDRAFT_126917.1.1 m.38168 sp YKIC_SCHPO 29.348 184 118 6 4 178 39 219 3.72E-16 79 YKIC_SCHPO reviewed Uncharacterized protein C630.12 SPAC630.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 422 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0005783; GO:0005789; GO:0006888; GO:0016021; GO:0016787 0 0 0 PF00149; Q9Y2M2 CHOYP_LOC763611.1.2 m.11441 sp SSUH2_HUMAN 37.037 324 190 4 65 380 36 353 3.72E-71 229 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 Q9YHV4 CHOYP_LOC100695151.2.2 m.30573 sp FSTA_DANRE 30.081 123 54 5 67 185 134 228 3.72E-07 52.8 FSTA_DANRE reviewed Follistatin-A (FS) (Activin-binding protein) (Follistatin-1) (zFst1) fsta fst fst1 si:dkey-111k10.2 si:dkeyp-88a5.1 Danio rerio (Zebrafish) (Brachydanio rerio) 322 determination of dorsal identity [GO:0048263]; dorsal/ventral pattern formation [GO:0009953]; embryonic viscerocranium morphogenesis [GO:0048703]; midbrain development [GO:0030901]; oocyte differentiation [GO:0009994]; otic placode formation [GO:0043049] GO:0005576; GO:0009953; GO:0009994; GO:0030901; GO:0043049; GO:0048263; GO:0048703 0 0 0 PF09289;PF07648; A4IF63 CHOYP_LOC100369733.1.1 m.61154 sp TRIM2_BOVIN 27.041 196 129 8 168 359 536 721 3.73E-08 58.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_LOC100557340.1.1 m.25172 sp CRNS1_HUMAN 31.771 192 114 6 3 177 100 291 3.73E-10 61.2 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 O42248 CHOYP_GBLP.6.7 m.57426 sp GBLP_DANRE 86.486 259 35 0 1 259 5 263 3.73E-172 482 GBLP_DANRE reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Danio rerio (Zebrafish) (Brachydanio rerio) 317 angiogenesis [GO:0001525]; convergent extension involved in gastrulation [GO:0060027]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0001525; GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:0060027; GO:2000114; GO:2000543 0 0 0 PF00400; P05450 CHOYP_BRAFLDRAFT_67194.2.2 m.51267 sp YAT7_RHOBL 39.726 73 43 1 91 163 33 104 3.73E-10 57.4 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P09487 CHOYP_ALPI.2.1.1 m.44767 sp PPBT_BOVIN 50.52 481 219 8 25 498 29 497 3.73E-159 466 PPBT_BOVIN reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Bos taurus (Bovine) 524 biomineral tissue development [GO:0031214]; cellular response to organic cyclic compound [GO:0071407]; developmental process involved in reproduction [GO:0003006]; endochondral ossification [GO:0001958]; osteoblast differentiation [GO:0001649]; response to antibiotic [GO:0046677]; response to vitamin D [GO:0033280] GO:0001649; GO:0001958; GO:0003006; GO:0004035; GO:0005578; GO:0005886; GO:0016462; GO:0031214; GO:0031225; GO:0033280; GO:0046677; GO:0046872; GO:0065010; GO:0070062; GO:0071407 0 0 0 PF00245; P10155 CHOYP_LOC100634688.2.6 m.21980 sp RO60_HUMAN 38.625 611 293 10 23 630 2 533 3.73E-135 409 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P18433 CHOYP_PTPRC.1.14 m.4043 sp PTPRA_HUMAN 29.377 674 420 20 39 674 139 794 3.73E-74 258 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; Q00988 CHOYP_BRAFLDRAFT_214346.1.1 m.56462 sp CY1_KLULA 49.11 281 136 4 64 339 14 292 3.73E-86 265 CY1_KLULA reviewed "Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)" CYT1 KLLA0F16555g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) 292 "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" GO:0005750; GO:0006122; GO:0020037; GO:0045153; GO:0046872 0 0 0 PF02167; Q3T0K1 CHOYP_CALU.1.1 m.19774 sp CALU_BOVIN 66.292 89 30 0 24 112 227 315 3.73E-38 133 CALU_BOVIN reviewed Calumenin CALU Bos taurus (Bovine) 315 0 GO:0005509; GO:0005576; GO:0005789; GO:0005794; GO:0033018; GO:0042470 0 0 0 PF13202;PF13499;PF13833; Q5BIM1 CHOYP_BRAFLDRAFT_82869.2.6 m.33393 sp TRI45_BOVIN 23.585 212 138 4 12 214 133 329 3.73E-11 68.9 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PDG5 CHOYP_SMRC2.1.2 m.19460 sp SMRC2_MOUSE 80 35 7 0 1 35 913 947 3.73E-11 63.5 SMRC2_MOUSE reviewed SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2) Smarcc2 Baf170 Mus musculus (Mouse) 1213 "ATP-dependent chromatin remodeling [GO:0043044]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome disassembly [GO:0006337]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment [GO:0021882]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0000978; GO:0000980; GO:0003682; GO:0005654; GO:0006337; GO:0006338; GO:0006351; GO:0016514; GO:0016569; GO:0017053; GO:0021882; GO:0043044; GO:0043234; GO:0045892; GO:0045893; GO:0071564; GO:0071565; GO:0090544 0 0 0 PF00249;PF04433;PF16495;PF16496;PF16498; Q6PDJ1 CHOYP_CAHD1.6.6 m.63025 sp CAHD1_MOUSE 26.325 1113 707 39 26 1064 59 1132 3.73E-91 322 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q70E20 CHOYP_DLLC.2.2 m.27073 sp SNED1_MOUSE 42.958 142 77 4 1 139 762 902 3.73E-28 124 SNED1_MOUSE reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Secreted protein SST-3) (Stromal nidogen extracellular matrix protein)" Sned1 Snep Mus musculus (Mouse) 1403 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q8Q0U0 CHOYP_SECG.1.3 m.32593 sp Y045_METMA 39.691 194 117 0 1 194 158 351 3.73E-33 124 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q96RW7 CHOYP_PHUM_PHUM068980.2.5 m.42133 sp HMCN1_HUMAN 23.478 345 211 13 160 478 3489 3806 3.73E-07 58.2 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9HBL0 CHOYP_TENS3.1.4 m.37686 sp TENS1_HUMAN 46.448 366 170 5 8 348 6 370 3.73E-109 377 TENS1_HUMAN reviewed Tensin-1 TNS1 TNS Homo sapiens (Human) 1735 cell-substrate junction assembly [GO:0007044]; fibroblast migration [GO:0010761] GO:0005737; GO:0005856; GO:0005925; GO:0007044; GO:0009986; GO:0010761; GO:0044822 0 0 0 PF08416;PF10409;PF00017; Q9P2N4 CHOYP_ATS20.1.2 m.40047 sp ATS9_HUMAN 31.034 174 117 2 1 172 1515 1687 3.73E-26 107 ATS9_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) 1935 glycoprotein catabolic process [GO:0006516]; multicellular organism development [GO:0007275]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; vesicle-mediated transport [GO:0016192] GO:0004222; GO:0005578; GO:0005615; GO:0005783; GO:0006508; GO:0006516; GO:0007275; GO:0008237; GO:0008270; GO:0009986; GO:0015031; GO:0016192; GO:0045636 0 0 0 PF05986;PF08685;PF01562;PF01421;PF00090; Q9W0K0 CHOYP_PHUM_PHUM501210.1.1 m.10755 sp JIP1_DROME 48.872 133 64 2 442 573 272 401 3.73E-31 130 JIP1_DROME reviewed JNK-interacting protein 1 (JIP-1) (APP-like-interacting protein 1) (APLIP1) (Protein eye developmental SP512) Aplip1 SP512 CG1200 Drosophila melanogaster (Fruit fly) 490 anterograde synaptic vesicle transport [GO:0048490]; axonal transport of mitochondrion [GO:0019896]; JNK cascade [GO:0007254]; neuron projection morphogenesis [GO:0048812]; regulation of JNK cascade [GO:0046328]; regulation of terminal button organization [GO:2000331]; retrograde synaptic vesicle transport [GO:0048491] GO:0005078; GO:0007254; GO:0019894; GO:0019896; GO:0019901; GO:0030424; GO:0042802; GO:0046328; GO:0048490; GO:0048491; GO:0048812; GO:1904115; GO:2000331 0 0 0 PF00640;PF14604; Q9Y4C0 CHOYP_LOC100720440.1.2 m.11473 sp NRX3A_HUMAN 26.444 329 184 14 827 1135 251 541 3.73E-13 78.2 NRX3A_HUMAN reviewed Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) NRXN3 C14orf60 KIAA0743 Homo sapiens (Human) 1643 adult behavior [GO:0030534]; axon guidance [GO:0007411]; learning [GO:0007612]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] GO:0004872; GO:0005246; GO:0005887; GO:0007158; GO:0007269; GO:0007411; GO:0007416; GO:0007612; GO:0030534; GO:0035176; GO:0043234; GO:0046872; GO:0050839; GO:0051965; GO:0071625; GO:0090129; GO:0097109; GO:0098793 0 0 0 PF00008;PF02210;PF01034; O14832 CHOYP_LOC100690874.1.2 m.62880 sp PAHX_HUMAN 60.486 329 122 3 2 326 7 331 3.74E-152 433 PAHX_HUMAN reviewed "Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH)" PHYH PAHX Homo sapiens (Human) 338 fatty acid alpha-oxidation [GO:0001561]; isoprenoid metabolic process [GO:0006720]; methyl-branched fatty acid metabolic process [GO:0097089] GO:0001561; GO:0005739; GO:0005777; GO:0005782; GO:0006720; GO:0031418; GO:0046872; GO:0048037; GO:0048244; GO:0097089 PATHWAY: Lipid metabolism; fatty acid metabolism. 0 0 PF05721; O15553 CHOYP_LOC100374741.47.83 m.42411 sp MEFV_HUMAN 35 60 39 0 62 121 373 432 3.74E-06 49.3 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; O88874 CHOYP_LOC100123595.2.2 m.67039 sp CCNK_MOUSE 72.321 112 31 0 11 122 22 133 3.74E-57 188 CCNK_MOUSE reviewed Cyclin-K Ccnk Mus musculus (Mouse) 554 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; in utero embryonic development [GO:0001701]; mitotic nuclear division [GO:0007067]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of cell cycle arrest [GO:0071157]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of phosphorylation of RNA polymerase II C-terminal domain [GO:1901409]; positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues [GO:2001165]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000307; GO:0001701; GO:0002944; GO:0002945; GO:0004693; GO:0005634; GO:0005654; GO:0006351; GO:0006974; GO:0007067; GO:0008353; GO:0016538; GO:0019901; GO:0044828; GO:0045737; GO:0045944; GO:0051301; GO:0071157; GO:1901409; GO:2001165 0 0 0 PF02984;PF00134; P06731 CHOYP_CEAM5.2.6 m.42440 sp CEAM5_HUMAN 25.267 281 159 14 68 331 65 311 3.74E-06 52.8 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; P12938 CHOYP_LOC584123.1.1 m.48949 sp CP2D3_RAT 28.458 506 307 18 17 490 13 495 3.74E-49 179 CP2D3_RAT reviewed Cytochrome P450 2D3 (EC 1.14.14.1) (CYPIID3) (Cytochrome P450-DB3) (Debrisoquine 4-hydroxylase) Cyp2d3 Cyp2d-3 Rattus norvegicus (Rat) 500 arachidonic acid metabolic process [GO:0019369]; liver development [GO:0001889] GO:0001889; GO:0004497; GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019369; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P13813 CHOYP_LOC100375776.2.3 m.28493 sp 110KD_PLAKN 42.771 166 95 0 177 342 131 296 3.74E-24 107 110KD_PLAKN reviewed 110 kDa antigen (PK110) (Fragment) 0 Plasmodium knowlesi 296 0 0 0 0 0 0 P16157 CHOYP_TVAG_168010.1.45 m.2389 sp ANK1_HUMAN 34.103 780 506 2 158 933 11 786 3.74E-122 415 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18433 CHOYP_PTPRA.19.22 m.59233 sp PTPRA_HUMAN 29.661 708 445 24 271 951 104 785 3.74E-77 272 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P42519 CHOYP_STAR.3.4 m.45581 sp STAR_DROME 36.364 121 72 3 328 444 420 539 3.74E-14 78.2 STAR_DROME reviewed Protein Star S CG4385 Drosophila melanogaster (Fruit fly) 597 "behavioral response to ethanol [GO:0048149]; branched duct epithelial cell fate determination, open tracheal system [GO:0046845]; compound eye photoreceptor cell differentiation [GO:0001751]; compound eye retinal cell programmed cell death [GO:0046667]; determination of genital disc primordium [GO:0035225]; epidermal growth factor receptor ligand maturation [GO:0038004]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; imaginal disc-derived wing morphogenesis [GO:0007476]; ommatidial rotation [GO:0016318]; oogenesis [GO:0048477]; protein targeting to Golgi [GO:0000042]; R7 cell development [GO:0045467]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; stem cell fate commitment [GO:0048865]; stomatogastric nervous system development [GO:0007421]; visual perception [GO:0007601]" GO:0000042; GO:0000139; GO:0001751; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0007173; GO:0007421; GO:0007476; GO:0007601; GO:0016020; GO:0016021; GO:0016318; GO:0035225; GO:0038004; GO:0042058; GO:0045467; GO:0046667; GO:0046845; GO:0048149; GO:0048477; GO:0048865; GO:0061331; GO:0097038 0 0 0 0 Q0P5B9 CHOYP_LOC100000333.1.1 m.43667 sp ANR39_BOVIN 50.658 152 75 0 14 165 12 163 3.74E-49 160 ANR39_BOVIN reviewed Ankyrin repeat domain-containing protein 39 ANKRD39 Bos taurus (Bovine) 183 0 0 0 0 0 PF12796; Q24JV9 CHOYP_TVAG_355490.13.22 m.47154 sp L3BPA_DANRE 50.943 106 51 1 954 1058 27 132 3.74E-29 127 L3BPA_DANRE reviewed Galectin-3-binding protein A (Lectin galactoside-binding soluble 3-binding protein A) lgals3bpa lgals3bp zgc:136780 Danio rerio (Zebrafish) (Brachydanio rerio) 567 cell adhesion [GO:0007155] GO:0005044; GO:0005578; GO:0007155; GO:0016020 0 0 0 PF07707;PF00651;PF00530; Q32KR8 CHOYP_BRAFLDRAFT_212086.10.11 m.63093 sp ADPRH_BOVIN 55.556 351 149 4 7 356 8 352 3.74E-129 381 ADPRH_BOVIN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Bos taurus (Bovine) 353 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q504Y2 CHOYP_BRAFLDRAFT_123481.1.1 m.46176 sp PKDCC_HUMAN 40.659 364 211 4 103 464 132 492 3.74E-90 286 PKDCC_HUMAN reviewed "Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)" PKDCC SGK493 VLK Homo sapiens (Human) 493 bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; limb morphogenesis [GO:0035108]; lung alveolus development [GO:0048286]; multicellular organism growth [GO:0035264]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; palate development [GO:0060021]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; protein transport [GO:0015031]; skeletal system development [GO:0001501] GO:0001501; GO:0004672; GO:0004715; GO:0005524; GO:0005576; GO:0005794; GO:0015031; GO:0018108; GO:0030154; GO:0030282; GO:0030501; GO:0032332; GO:0035108; GO:0035264; GO:0042997; GO:0048286; GO:0048566; GO:0060021 0 0 0 PF12260; Q6DBR9 CHOYP_BRAFLDRAFT_125658.1.1 m.27105 sp KXDL1_DANRE 42.958 142 70 3 15 154 1 133 3.74E-29 111 KXDL1_DANRE reviewed KxDL motif-containing protein 1 kxd1 zgc:91862 Danio rerio (Zebrafish) (Brachydanio rerio) 182 lysosome localization [GO:0032418]; vesicle-mediated transport [GO:0016192] GO:0016192; GO:0032418; GO:0043234 0 0 0 PF10241; Q6PBU5 CHOYP_GRT1A.1.2 m.29772 sp GRT1A_DANRE 41.317 334 164 4 6 307 18 351 3.74E-89 273 GRT1A_DANRE reviewed Growth hormone-regulated TBC protein 1-A grtp1a grtp1 Danio rerio (Zebrafish) (Brachydanio rerio) 356 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF00566; Q7SXL7 CHOYP_LOC100121674.1.1 m.62647 sp FL2D_DANRE 49.43 263 126 4 7 267 8 265 3.74E-76 241 FL2D_DANRE reviewed Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) wtap ch211-195e3.2 zgc:66202 Danio rerio (Zebrafish) (Brachydanio rerio) 423 "cell cycle [GO:0007049]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" GO:0000381; GO:0005634; GO:0006397; GO:0007049; GO:0008380; GO:0016607; GO:0036396; GO:0042981; GO:0080009 0 0 0 PF17098; Q8N128 CHOYP_LOC100372427.1.1 m.25211 sp F177A_HUMAN 55.285 123 48 3 31 148 49 169 3.74E-32 117 F177A_HUMAN reviewed Protein FAM177A1 FAM177A1 C14orf24 Homo sapiens (Human) 213 0 0 0 0 0 PF14774; Q8NFZ3 CHOYP_NLGN2.2.3 m.43831 sp NLGNY_HUMAN 30.164 610 346 21 1 560 20 599 3.74E-69 242 NLGNY_HUMAN reviewed "Neuroligin-4, Y-linked (Neuroligin Y)" NLGN4Y KIAA0951 Homo sapiens (Human) 816 learning [GO:0007612]; modulation of synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625] GO:0004872; GO:0005887; GO:0007158; GO:0007416; GO:0007612; GO:0009986; GO:0014069; GO:0030054; GO:0035176; GO:0042043; GO:0045202; GO:0045211; GO:0050804; GO:0050839; GO:0052689; GO:0071625; GO:0097110 0 0 0 PF00135; Q96GP6 CHOYP_SREC.3.4 m.51010 sp SREC2_HUMAN 40.441 136 69 5 171 302 236 363 3.74E-18 88.2 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9C0A0 CHOYP_AXO.1.1 m.44228 sp CNTP4_HUMAN 25.402 996 617 39 285 1219 193 1123 3.74E-63 241 CNTP4_HUMAN reviewed Contactin-associated protein-like 4 (Cell recognition molecule Caspr4) CNTNAP4 CASPR4 KIAA1763 Homo sapiens (Human) 1308 "cell adhesion [GO:0007155]; regulation of grooming behavior [GO:2000821]; regulation of synaptic transmission, dopaminergic [GO:0032225]; regulation of synaptic transmission, GABAergic [GO:0032228]" GO:0007155; GO:0016021; GO:0030054; GO:0030425; GO:0032225; GO:0032228; GO:0042734; GO:2000821 0 0 0 PF00754;PF02210; Q9D7P6 CHOYP_LOC100707299.1.1 m.15098 sp ISCU_MOUSE 84.906 106 16 0 6 111 55 160 3.74E-62 190 ISCU_MOUSE reviewed "Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein)" Iscu Nifun Mus musculus (Mouse) 168 [2Fe-2S] cluster assembly [GO:0044571]; cellular iron ion homeostasis [GO:0006879]; protein maturation by iron-sulfur cluster transfer [GO:0097428] GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006879; GO:0008198; GO:0032947; GO:0036455; GO:0044571; GO:0051537; GO:0051539; GO:0097428 0 0 cd06664; PF01592; Q9R085 CHOYP_UBP15.2.4 m.43117 sp UBP15_RAT 51.282 195 93 2 1 195 38 230 3.74E-54 198 UBP15_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin carboxyl-terminal hydrolase of 109 kDa) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) Usp15 ubp109 Rattus norvegicus (Rat) 952 BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; protein deubiquitination [GO:0016579]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004197; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0007179; GO:0016579; GO:0030509; GO:0035520; GO:0035616; GO:0060389 0 0 0 PF06337;PF14836;PF00443;PF14533; Q9VZW5 CHOYP_FMAR.1.1 m.51332 sp FMAR_DROME 26.254 339 214 10 15 332 78 401 3.74E-21 98.2 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; Q9WV72 CHOYP_ANR44.4.5 m.61389 sp ASB3_MOUSE 35.849 212 118 6 111 319 74 270 3.74E-27 114 ASB3_MOUSE reviewed Ankyrin repeat and SOCS box protein 3 (ASB-3) Asb3 Mus musculus (Mouse) 525 intracellular signal transduction [GO:0035556] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0031625; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF13606;PF07525; A4IF63 CHOYP_BRAFLDRAFT_87334.2.4 m.6036 sp TRIM2_BOVIN 25.203 123 91 1 99 221 622 743 3.75E-06 51.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6QQ21 CHOYP_LOC592528.2.2 m.63564 sp CSN6_BOVIN 72.917 288 77 1 5 292 27 313 3.75E-159 454 CSN6_BOVIN reviewed COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) COPS6 Bos taurus (Bovine) 324 cullin deneddylation [GO:0010388] GO:0005737; GO:0008180; GO:0010388 0 0 0 PF01398;PF13012; O75342 CHOYP_LOC584481.6.10 m.53869 sp LX12B_HUMAN 29.253 482 273 20 132 580 255 701 3.75E-42 164 LX12B_HUMAN reviewed "Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)" ALOX12B Homo sapiens (Human) 701 arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipoxygenase pathway [GO:0019372]; oxidation-reduction process [GO:0055114]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665] GO:0004052; GO:0005506; GO:0005829; GO:0006497; GO:0006665; GO:0010628; GO:0016702; GO:0019369; GO:0019372; GO:0043410; GO:0043651; GO:0046513; GO:0051122; GO:0055114; GO:0061436; GO:0070257; GO:1990136 PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:21558561}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:21558561}. 0 0 PF00305;PF01477; P19217 CHOYP_ST1C3.1.1 m.53686 sp ST1E1_BOVIN 32.857 280 171 7 64 334 19 290 3.75E-42 151 ST1E1_BOVIN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) 295 estrogen metabolic process [GO:0008210] GO:0004304; GO:0005496; GO:0005737; GO:0008210; GO:0050294 0 0 0 PF00685; P20825 CHOYP_contig_005892 m.6742 sp POL2_DROME 43.087 311 169 3 2 310 318 622 3.75E-76 273 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P33005 CHOYP_LOC100375670.1.1 m.45650 sp KALM_CHICK 49.057 53 25 1 293 343 115 167 3.75E-09 62.4 KALM_CHICK reviewed Anosmin-1 (Kallmann syndrome protein homolog) ANOS1 KAL KAL1 Gallus gallus (Chicken) 675 cell adhesion [GO:0007155] GO:0004867; GO:0005576; GO:0007155; GO:0009986 0 0 0 PF00041;PF00095; P36975 CHOYP_LOC100533400.2.4 m.25003 sp SNP25_DROME 55 200 85 3 16 213 15 211 3.75E-66 206 SNP25_DROME reviewed Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) Snap25 CG40452 Drosophila melanogaster (Fruit fly) 212 Golgi to plasma membrane transport [GO:0006893]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] GO:0000149; GO:0005484; GO:0005737; GO:0005886; GO:0006893; GO:0006906; GO:0007269; GO:0007274; GO:0016020; GO:0016081; GO:0016082; GO:0016192; GO:0019905; GO:0030054; GO:0031201; GO:0031629; GO:0043195; GO:0048172; GO:0048489 0 0 0 PF00835; P41214 CHOYP_LOC101067905.1.1 m.42386 sp EIF2D_HUMAN 41.228 570 314 7 1 566 1 553 3.75E-131 399 EIF2D_HUMAN reviewed Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin) EIF2D HCA56 LGTN Homo sapiens (Human) 584 formation of translation preinitiation complex [GO:0001731]; intracellular protein transport [GO:0006886]; IRES-dependent translational initiation [GO:0002192]; ribosome disassembly [GO:0032790] GO:0001731; GO:0002192; GO:0003743; GO:0004872; GO:0005634; GO:0005737; GO:0006886; GO:0032790 0 0 0 PF01253; Q05B56 CHOYP_LOC100024026.1.1 m.4933 sp TF2H3_BOVIN 56.357 291 114 6 9 291 11 296 3.75E-112 330 TF2H3_BOVIN reviewed General transcription factor IIH subunit 3 (General transcription factor IIH polypeptide 3) GTF2H3 Bos taurus (Bovine) 309 nucleotide-excision repair [GO:0006289]; phosphorylation of RNA polymerase II C-terminal domain [GO:0070816]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000439; GO:0003684; GO:0005675; GO:0006289; GO:0006366; GO:0008135; GO:0046872; GO:0070816 0 0 0 PF03850; Q06805 CHOYP_MEG10.8.91 m.19956 sp TIE1_BOVIN 32.192 146 73 10 199 328 210 345 3.75E-11 68.6 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q08420 CHOYP_contig_048898 m.58002 sp SODE_RAT 28.346 127 75 4 46 159 100 223 3.75E-08 54.3 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q12983 CHOYP_LOC100374378.1.1 m.14980 sp BNIP3_HUMAN 33.333 180 86 8 6 153 10 187 3.75E-13 67 BNIP3_HUMAN reviewed BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 BNIP3 NIP3 Homo sapiens (Human) 194 apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; brown fat cell differentiation [GO:0050873]; cell death [GO:0008219]; cellular response to cobalt ion [GO:0071279]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; intrinsic apoptotic signaling pathway in response to hypoxia [GO:1990144]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial outer membrane permeabilization [GO:0097345]; mitochondrial protein catabolic process [GO:0035694]; mitophagy [GO:0000422]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell death [GO:0060548]; negative regulation of membrane potential [GO:0045837]; negative regulation of mitochondrial fusion [GO:0010637]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of macroautophagy [GO:0016239]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein complex disassembly [GO:0043243]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; reactive oxygen species metabolic process [GO:0072593]; regulation of aerobic respiration [GO:1903715]; regulation of mitochondrial membrane permeability [GO:0046902]; response to hyperoxia [GO:0055093]; response to hypoxia [GO:0001666]; toxin transport [GO:1901998] GO:0000422; GO:0001666; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005739; GO:0005741; GO:0005783; GO:0006915; GO:0008219; GO:0008626; GO:0010508; GO:0010637; GO:0010666; GO:0016239; GO:0030425; GO:0031307; GO:0031966; GO:0035694; GO:0042802; GO:0042803; GO:0043065; GO:0043066; GO:0043068; GO:0043243; GO:0043653; GO:0045837; GO:0046902; GO:0046982; GO:0048102; GO:0050873; GO:0051020; GO:0051402; GO:0051607; GO:0055093; GO:0060548; GO:0070301; GO:0071260; GO:0071279; GO:0071456; GO:0072593; GO:0090141; GO:0090200; GO:0097345; GO:1901998; GO:1903715; GO:1990144; GO:2000378 0 0 0 PF06553; Q13263 CHOYP_LOC100368204.3.3 m.53341 sp TIF1B_HUMAN 23.78 164 116 5 1 158 169 329 3.75E-08 57 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q14BN4 CHOYP_SLMAP.4.8 m.24028 sp SLMAP_HUMAN 40.199 806 381 19 23 749 12 795 3.75E-145 451 SLMAP_HUMAN reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) 828 muscle contraction [GO:0006936] GO:0005790; GO:0005815; GO:0005887; GO:0006936; GO:0042383 0 0 0 PF00498; Q2KI24 CHOYP_BRAFLDRAFT_266781.1.2 m.24880 sp MTHSD_BOVIN 62.151 251 95 0 23 273 7 257 3.75E-113 343 MTHSD_BOVIN reviewed Methenyltetrahydrofolate synthase domain-containing protein MTHFSD Bos taurus (Bovine) 380 0 GO:0000166; GO:0044822 0 0 0 PF01812;PF00076; Q2TAD9 CHOYP_LOC100372774.1.2 m.50500 sp CYR1B_XENLA 53.353 343 147 4 6 345 32 364 3.75E-135 392 CYR1B_XENLA reviewed Cysteine and histidine-rich protein 1-B cyhr1-b Xenopus laevis (African clawed frog) 365 0 GO:0005737; GO:0008270 0 0 0 0 Q3KPW1 CHOYP_RNP1B.1.1 m.59888 sp RNP1B_XENLA 64.545 110 39 0 100 209 118 227 3.75E-47 161 RNP1B_XENLA reviewed RNA-binding protein with serine-rich domain 1-B rnps1-b Xenopus laevis (African clawed frog) 283 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005737; GO:0006397; GO:0008380; GO:0016607 0 0 0 PF00076; Q5IS99 CHOYP_contig_045638 m.53167 sp CASP3_SAIBB 27.711 83 56 1 1 83 198 276 3.75E-06 47 CASP3_SAIBB reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q5ZJ87 CHOYP_CG060.1.2 m.46608 sp BMT2_CHICK 40.517 348 187 7 34 363 34 379 3.75E-72 233 BMT2_CHICK reviewed Probable methyltransferase BTM2 homolog (EC 2.1.1.-) RCJMB04_20b4 Gallus gallus (Chicken) 408 0 GO:0016433 0 0 0 PF11968; Q6GNY1 CHOYP_LOC100487670.7.13 m.37059 sp MIB1_XENLA 42.254 71 38 2 623 693 13 80 3.75E-08 61.2 MIB1_XENLA reviewed E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Mind bomb homolog 1) mib1 Xenopus laevis (African clawed frog) 1011 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0005815; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6IPM2 CHOYP_LOC100888457.1.2 m.34827 sp IQCE_HUMAN 35.586 222 136 3 173 388 136 356 3.75E-34 143 IQCE_HUMAN reviewed IQ domain-containing protein E IQCE KIAA1023 Homo sapiens (Human) 695 0 GO:0072372 0 0 0 PF00612; Q6PFY8 CHOYP_LOC100373137.2.3 m.46726 sp TRI45_MOUSE 21.26 381 250 13 2 354 38 396 3.75E-09 63.2 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6TFL4 CHOYP_KLH24.6.6 m.62812 sp KLH24_HUMAN 28 550 363 11 29 569 66 591 3.75E-54 197 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q6ZSB9 CHOYP_LOC100008030.1.1 m.10817 sp ZBT49_HUMAN 32.642 193 101 4 982 1148 396 585 3.75E-24 113 ZBT49_HUMAN reviewed Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) ZBTB49 ZNF509 Homo sapiens (Human) 765 "cell cycle arrest [GO:0007050]; negative regulation of cell proliferation [GO:0008285]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0001223; GO:0005634; GO:0005737; GO:0006351; GO:0007050; GO:0008134; GO:0008285; GO:0043565; GO:0045944; GO:0046872 0 0 0 PF00651;PF00096;PF13912; Q86RS3 CHOYP_contig_025181 m.28680 sp DFP_MANSE 26.776 183 109 10 19 196 1 163 3.75E-06 49.3 DFP_MANSE reviewed Putative defense protein Hdd11-like 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 166 defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087] GO:0005576; GO:0042742; GO:0042832; GO:0045087 0 0 cd08544; PF02014; Q8HXX6 CHOYP_LOC100346953.1.2 m.19801 sp SAP3_MACFA 31.148 183 113 5 32 205 10 188 3.75E-27 105 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q9ESM0 CHOYP_IP6K1.1.1 m.54347 sp IP6K1_RAT 43.902 410 179 9 15 377 24 429 3.75E-110 332 IP6K1_RAT reviewed Inositol hexakisphosphate kinase 1 (InsP6 kinase 1) (EC 2.7.4.21) (Inositol hexaphosphate kinase 1) Ip6k1 Ihpk1 Rattus norvegicus (Rat) 433 phosphatidylinositol phosphorylation [GO:0046854] GO:0000832; GO:0005524; GO:0005730; GO:0005737; GO:0008440; GO:0046854; GO:0052723; GO:0052724 0 0 0 PF03770; Q9ESN6 CHOYP_BRAFLDRAFT_69798.18.22 m.53343 sp TRIM2_MOUSE 30.052 193 105 8 288 467 534 709 3.75E-12 72.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM3.7.58 m.8070 sp TRIM2_MOUSE 27.5 200 127 7 150 343 516 703 3.75E-11 67.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NR12 CHOYP_contig_009176 m.10652 sp PDLI7_HUMAN 33.4 497 260 11 19 501 13 452 3.75E-77 253 PDLI7_HUMAN reviewed PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma) PDLIM7 ENIGMA Homo sapiens (Human) 457 actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; ossification [GO:0001503]; positive regulation of osteoblast differentiation [GO:0045669]; receptor-mediated endocytosis [GO:0006898] GO:0001503; GO:0001725; GO:0001726; GO:0005634; GO:0005737; GO:0005911; GO:0005925; GO:0006898; GO:0007275; GO:0008270; GO:0015629; GO:0030036; GO:0030154; GO:0045669 0 0 0 PF00412;PF00595; A2SWM2 CHOYP_LOC587502.1.1 m.40597 sp SPNS2_DANRE 27.525 396 230 15 163 520 113 489 3.76E-18 90.9 SPNS2_DANRE reviewed Protein spinster homolog 2 (Protein two of hearts) spns2 toh Danio rerio (Zebrafish) (Brachydanio rerio) 504 cardioblast migration to the midline involved in heart rudiment formation [GO:0003319]; embryonic heart tube morphogenesis [GO:0003143]; embryonic viscerocranium morphogenesis [GO:0048703]; patterning of blood vessels [GO:0001569]; regulation of cartilage development [GO:0061035]; sphingosine-1-phosphate signaling pathway [GO:0003376]; transmembrane transport [GO:0055085]; vasculature development [GO:0001944] GO:0001569; GO:0001944; GO:0003143; GO:0003319; GO:0003376; GO:0005765; GO:0016021; GO:0031982; GO:0046624; GO:0048703; GO:0055085; GO:0061035 0 0 cd06174; PF07690; P14133 CHOYP_LOC100376857.3.7 m.41465 sp ASO_CUCSA 27.124 612 311 19 102 671 58 576 3.76E-52 194 ASO_CUCSA reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) 0 Cucumis sativus (Cucumber) 587 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P27600 CHOYP_LOC100371005.2.2 m.6206 sp GNA12_MOUSE 65.294 340 116 1 38 375 40 379 3.76E-163 464 GNA12_MOUSE reviewed Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12) Gna12 Gna-12 Mus musculus (Mouse) 379 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell differentiation [GO:0030154]; embryonic digit morphogenesis [GO:0042733]; G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; regulation of cell shape [GO:0008360]; regulation of fibroblast migration [GO:0010762]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of TOR signaling [GO:0032006]; response to drug [GO:0042493]; Rho protein signal transduction [GO:0007266] GO:0001701; GO:0003924; GO:0004871; GO:0005525; GO:0005834; GO:0005925; GO:0007186; GO:0007188; GO:0007266; GO:0008360; GO:0010762; GO:0030154; GO:0031526; GO:0031683; GO:0031752; GO:0032006; GO:0032434; GO:0035556; GO:0042493; GO:0042733; GO:0046872 0 0 0 PF00503; P37167 CHOYP_PGTG_12376.1.2 m.43330 sp ACTP_ACACA 30.147 136 91 1 11 146 2 133 3.76E-24 99.8 ACTP_ACACA reviewed Actophorin 0 Acanthamoeba castellanii (Amoeba) 138 actin filament depolymerization [GO:0030042] GO:0005737; GO:0015629; GO:0030042 0 0 cd11286; PF00241; P56616 CHOYP_UBE2C.1.1 m.55757 sp UBE2C_XENLA 68.333 180 54 2 24 202 1 178 3.76E-84 249 UBE2C_XENLA reviewed Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UBC-X) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C) ube2c ubch10 ubcx Xenopus laevis (African clawed frog) 179 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; protein K11-linked ubiquitination [GO:0070979]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005524; GO:0005680; GO:0006511; GO:0010458; GO:0010994; GO:0016740; GO:0031145; GO:0051301; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q02505 CHOYP_MUC12.1.2 m.17125 sp MUC3A_HUMAN 25.243 206 124 9 244 427 3022 3219 3.76E-06 53.1 MUC3A_HUMAN reviewed Mucin-3A (MUC-3A) (Intestinal mucin-3A) MUC3A MUC3 Homo sapiens (Human) 3323 O-glycan processing [GO:0016266] GO:0005201; GO:0005576; GO:0005796; GO:0016021; GO:0016266; GO:0030197 0 0 0 0 Q24JY3 CHOYP_BRAFLDRAFT_119496.1.1 m.17128 sp SPC24_BOVIN 34.737 95 62 0 107 201 103 197 3.76E-16 76.3 SPC24_BOVIN reviewed Kinetochore protein Spc24 SPC24 SPBC24 Bos taurus (Bovine) 197 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0005634; GO:0007067; GO:0031262; GO:0051301 0 0 0 PF08286; Q4V8X0 CHOYP_TPRA1.1.1 m.51400 sp TPRA1_DANRE 52.16 324 136 7 55 375 43 350 3.76E-108 326 TPRA1_DANRE reviewed Transmembrane protein adipocyte-associated 1 homolog (Integral membrane protein GPR175) tpra1 gpr175 zgc:114103 Danio rerio (Zebrafish) (Brachydanio rerio) 378 0 GO:0016021 0 0 0 PF10160; Q6AZB8 CHOYP_LOC588039.6.6 m.64807 sp HARB1_DANRE 35.692 325 196 5 24 336 22 345 3.76E-56 189 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6ZG77 CHOYP_BRAFLDRAFT_118823.1.2 m.5230 sp DCDA_ORYSJ 36.623 456 215 8 45 499 74 456 3.76E-88 281 DCDA_ORYSJ reviewed "Probable diaminopimelate decarboxylase, chloroplastic (DAP decarboxylase) (DAPDC) (EC 4.1.1.20)" LYSA Os02g0440000 LOC_Os02g24354 OJ1008_E02.6 OsJ_006351/OsJ_006352 Oryza sativa subsp. japonica (Rice) 490 lysine biosynthetic process via diaminopimelate [GO:0009089] GO:0008836; GO:0009089; GO:0009507 "PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." 0 cd06828; PF02784;PF00278; Q7SIC1 CHOYP_LOC100745682.1.1 m.34820 sp FUCL_ANGAN 38.356 146 77 5 200 337 10 150 3.76E-18 83.6 FUCL_ANGAN reviewed Fucolectin 0 Anguilla anguilla (European freshwater eel) (Muraena anguilla) 158 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005576; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q7SIG3 CHOYP_CELA1.2.3 m.27287 sp ELA1_SALSA 42.798 243 125 9 38 276 1 233 3.76E-52 173 ELA1_SALSA reviewed Elastase-1 (EC 3.4.21.36) 0 Salmo salar (Atlantic salmon) 236 0 GO:0004252; GO:0005576; GO:0046872 0 0 cd00190; PF00089; Q7TQC7 CHOYP_BRAFLDRAFT_73150.1.1 m.6880 sp GPTC2_MOUSE 27.126 494 262 18 23 427 23 507 3.76E-20 96.3 GPTC2_MOUSE reviewed G patch domain-containing protein 2 Gpatch2 Gpatc2 Mus musculus (Mouse) 527 negative regulation of phosphatase activity [GO:0010923] GO:0003676; GO:0005730; GO:0010923; GO:0016607 0 0 0 PF01585; Q80TV8 CHOYP_CLAP1.1.6 m.15729 sp CLAP1_MOUSE 37.423 163 72 4 1 133 707 869 3.76E-15 73.9 CLAP1_MOUSE reviewed CLIP-associating protein 1 (Cytoplasmic linker-associated protein 1) Clasp1 Kiaa0622 Mus musculus (Mouse) 1535 "astral microtubule organization [GO:0030953]; cell division [GO:0051301]; establishment of mitotic spindle localization [GO:0040001]; establishment of spindle orientation [GO:0051294]; exit from mitosis [GO:0010458]; Golgi organization [GO:0007030]; microtubule anchoring [GO:0034453]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of exocytosis [GO:0045921]; positive regulation of extracellular matrix disassembly [GO:0090091]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of focal adhesion assembly [GO:0051893]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]; vesicle targeting [GO:0006903]" GO:0000226; GO:0000776; GO:0000777; GO:0001578; GO:0002162; GO:0005794; GO:0005813; GO:0005828; GO:0005876; GO:0005881; GO:0005938; GO:0006903; GO:0007020; GO:0007026; GO:0007030; GO:0007052; GO:0008017; GO:0010458; GO:0010470; GO:0010634; GO:0010717; GO:0016020; GO:0030953; GO:0030981; GO:0031023; GO:0031111; GO:0031592; GO:0034453; GO:0040001; GO:0043515; GO:0045180; GO:0045921; GO:0051010; GO:0051294; GO:0051301; GO:0051497; GO:0051893; GO:0070062; GO:0070507; GO:0090091; GO:1903690; GO:1904261 0 0 0 PF12348; Q80Y83 CHOYP_LOC100377347.1.1 m.11235 sp DIXC1_MOUSE 36.123 717 383 16 120 790 20 707 3.76E-114 365 DIXC1_MOUSE reviewed Dixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1) Dixdc1 Ccd1 Kiaa1735 Mus musculus (Mouse) 711 canonical Wnt signaling pathway [GO:0060070]; cell cycle [GO:0007049]; cell proliferation in forebrain [GO:0021846]; cerebral cortex cell migration [GO:0021795]; cerebral cortex radially oriented cell migration [GO:0021799]; forebrain ventricular zone progenitor cell division [GO:0021869]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of microtubule cytoskeleton organization [GO:0070507] GO:0005737; GO:0005829; GO:0005925; GO:0007049; GO:0019904; GO:0021795; GO:0021799; GO:0021846; GO:0021869; GO:0030177; GO:0032956; GO:0043015; GO:0045665; GO:0060070; GO:0070507; GO:0090263 0 0 0 PF00307;PF00778; Q86Y13 CHOYP_NEMVEDRAFT_V1G248545.3.3 m.54719 sp DZIP3_HUMAN 28.777 139 92 3 22 154 393 530 3.76E-06 53.9 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8BHL8 CHOYP_LOC577551.1.1 m.30278 sp PSMF1_MOUSE 42.182 275 151 6 18 290 3 271 3.76E-70 221 PSMF1_MOUSE reviewed Proteasome inhibitor PI31 subunit Psmf1 Mus musculus (Mouse) 271 negative regulation of proteasomal protein catabolic process [GO:1901799]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000502; GO:0005783; GO:0005829; GO:0006511; GO:0016020; GO:0070628; GO:1901799 0 0 0 PF08577;PF11566; Q8K3Y6 CHOYP_LOC100665832.1.1 m.2956 sp ZCCHV_RAT 30 200 111 6 182 373 590 768 3.76E-17 87 ZCCHV_RAT reviewed Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger antiviral protein) (ZAP) (rZAP) Zc3hav1 Zap Rattus norvegicus (Rat) 776 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of mRNA catabolic process [GO:0061014]; regulation of defense response to virus by host [GO:0050691]; response to virus [GO:0009615] GO:0003723; GO:0005634; GO:0005737; GO:0009615; GO:0045071; GO:0045087; GO:0046872; GO:0050691; GO:0051607; GO:0061014 0 0 0 PF02825; Q90705 CHOYP_EF2.1.5 m.1544 sp EF2_CHICK 91.525 118 10 0 1 118 494 611 3.76E-68 223 EF2_CHICK reviewed Elongation factor 2 (EF-2) EEF2 Gallus gallus (Chicken) 858 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; Q9BX84 CHOYP_TRPM2.11.12 m.61269 sp TRPM6_HUMAN 20.769 650 399 19 60 641 136 737 3.76E-19 96.7 TRPM6_HUMAN reviewed Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6) TRPM6 CHAK2 Homo sapiens (Human) 2022 calcium ion transmembrane transport [GO:0070588]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636] GO:0004674; GO:0005262; GO:0005524; GO:0005886; GO:0009636; GO:0016021; GO:0016324; GO:0031526; GO:0046872; GO:0051262; GO:0070588 0 0 0 PF02816;PF00520;PF16519; Q9UKV3 CHOYP_LOC100185590.2.2 m.19230 sp ACINU_HUMAN 40.741 81 45 2 49 127 69 148 3.76E-08 58.2 ACINU_HUMAN reviewed Apoptotic chromatin condensation inducer in the nucleus (Acinus) ACIN1 ACINUS KIAA0670 Homo sapiens (Human) 1341 "apoptotic chromosome condensation [GO:0030263]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; erythrocyte differentiation [GO:0030218]; mitophagy in response to mitochondrial depolarization [GO:0098779]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of monocyte differentiation [GO:0045657]; RNA splicing [GO:0008380]; xenophagy [GO:0098792]" GO:0000166; GO:0002230; GO:0003676; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0006397; GO:0006921; GO:0008380; GO:0016607; GO:0016887; GO:0019899; GO:0030218; GO:0030263; GO:0043065; GO:0044822; GO:0045657; GO:0048025; GO:0061574; GO:0098779; GO:0098792 0 0 0 PF16294;PF02037; O01761 CHOYP_UNC89.18.19 m.58551 sp UNC89_CAEEL 28.256 407 241 21 194 580 4310 4685 3.77E-14 81.6 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O15553 CHOYP_BRAFLDRAFT_93307.1.1 m.6031 sp MEFV_HUMAN 36.667 60 38 0 37 96 373 432 3.77E-07 50.4 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; O70511 CHOYP_LOC584771.1.1 m.55681 sp ANK3_RAT 33.67 297 193 1 43 335 309 605 3.77E-41 160 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O75382 CHOYP_BRAFLDRAFT_205965.29.43 m.52674 sp TRIM3_HUMAN 25.41 122 89 1 341 460 622 743 3.77E-06 53.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P16331 CHOYP_PAH.1.1 m.49023 sp PH4H_MOUSE 48.544 412 198 4 14 411 13 424 3.77E-132 390 PH4H_MOUSE reviewed Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) Pah Mus musculus (Mouse) 453 L-phenylalanine catabolic process [GO:0006559]; protein hydroxylation [GO:0018126]; tetrahydrobiopterin metabolic process [GO:0046146]; tyrosine biosynthetic process [GO:0006571] GO:0004505; GO:0005506; GO:0006559; GO:0006571; GO:0016597; GO:0018126; GO:0046146; GO:0048037; GO:0070062 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6. 0 0 PF01842;PF00351; P48060 CHOYP_LOC100185684.1.1 m.30778 sp GLIP1_HUMAN 44.706 170 92 2 79 248 41 208 3.77E-43 153 GLIP1_HUMAN reviewed Glioma pathogenesis-related protein 1 (GliPR 1) (Protein RTVP-1) GLIPR1 GLIPR RTVP1 Homo sapiens (Human) 266 0 GO:0005576; GO:0005886; GO:0016020; GO:0016021 0 0 0 PF00188; P55210 CHOYP_XCASPASE-7.4.4 m.60712 sp CASP7_HUMAN 28.063 253 142 11 12 242 67 301 3.77E-17 82 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P74897 CHOYP_LOC100180023.6.7 m.63800 sp YQA3_THEAQ 40.26 77 36 1 76 142 61 137 3.77E-08 52 YQA3_THEAQ reviewed Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) 0 Thermus aquaticus 137 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q3LGD4 CHOYP_RFIP4.1.2 m.976 sp RFP4A_DANRE 32.308 455 255 15 76 513 201 619 3.77E-46 173 RFP4A_DANRE reviewed Rab11 family-interacting protein 4A (FIP4-Rab11) (Rab11-FIP4-A) (zRab11-FIP4-A) rab11fip4a rab11fip4 Danio rerio (Zebrafish) (Brachydanio rerio) 621 cytokinesis [GO:0000910]; eye morphogenesis [GO:0048592]; regulation of cell cycle [GO:0051726]; transport [GO:0006810] GO:0000910; GO:0003700; GO:0005509; GO:0005768; GO:0006810; GO:0017137; GO:0030139; GO:0030306; GO:0030496; GO:0032154; GO:0042803; GO:0043565; GO:0048592; GO:0051726; GO:0055038 0 0 0 PF07716;PF09457; Q4R4I6 CHOYP_CAP1.1.1 m.53395 sp CAP1_MACFA 57.353 204 73 3 1 197 278 474 3.77E-74 233 CAP1_MACFA reviewed Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 QtrA-13003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 475 actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902] GO:0000902; GO:0005886; GO:0030036 0 0 0 PF08603;PF01213; Q55BZ5 CHOYP_LOC100640867.1.1 m.4293 sp DCD1A_DICDI 34.298 449 260 11 4 433 9 441 3.77E-82 263 DCD1A_DICDI reviewed Protein dcd1A (Acid ceramidase-like protein A) dcd1A DDB_G0270296 Dictyostelium discoideum (Slime mold) 441 0 GO:0005576 0 0 0 0 Q5M786 CHOYP_WDR5.1.3 m.2168 sp WDR5_XENTR 76.087 92 21 1 26 117 8 98 3.77E-42 144 WDR5_XENTR reviewed WD repeat-containing protein 5 wdr5 TEgg065j14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 334 "histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0006351; GO:0006355; GO:0043981; GO:0043982; GO:0043984; GO:0071339 0 0 0 PF00400; Q5SW75 CHOYP_LOC724613.1.1 m.28406 sp SSH2_MOUSE 47.12 191 71 8 1 183 1 169 3.77E-36 136 SSH2_MOUSE reviewed Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (mSSH-2L) Ssh2 Kiaa1725 Ssh2l Mus musculus (Mouse) 1423 actin cytoskeleton organization [GO:0030036]; protein dephosphorylation [GO:0006470]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of lamellipodium assembly [GO:0010591] GO:0003677; GO:0003779; GO:0004721; GO:0004725; GO:0005615; GO:0005737; GO:0005856; GO:0005925; GO:0006470; GO:0008064; GO:0008138; GO:0010591; GO:0030036; GO:0050770 0 0 0 PF08766;PF00782; Q5XHG1 CHOYP_BRAFLDRAFT_128365.1.1 m.11706 sp NSMA3_XENLA 33.796 793 438 21 22 757 23 785 3.77E-133 418 NSMA3_XENLA reviewed Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III) smpd4 Xenopus laevis (African clawed frog) 824 0 GO:0000139; GO:0004767; GO:0005789; GO:0016021; GO:0046872; GO:0050290 0 0 0 PF14724; Q60631 CHOYP_BRAFLDRAFT_263599.1.1 m.59011 sp GRB2_MOUSE 55.3 217 86 2 1 213 1 210 3.77E-85 254 GRB2_MOUSE reviewed Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) Grb2 Mus musculus (Mouse) 217 aging [GO:0007568]; anatomical structure formation involved in morphogenesis [GO:0048646]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cell differentiation [GO:0030154]; cellular response to ionizing radiation [GO:0071479]; Fc-epsilon receptor signaling pathway [GO:0038095]; insulin receptor signaling pathway [GO:0008286]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein heterooligomerization [GO:0051291]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of MAPK cascade [GO:0043408]; signal transduction in response to DNA damage [GO:0042770] GO:0005070; GO:0005154; GO:0005168; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005768; GO:0005794; GO:0005829; GO:0005886; GO:0005911; GO:0007265; GO:0007568; GO:0008180; GO:0008286; GO:0012506; GO:0016020; GO:0017124; GO:0019901; GO:0019903; GO:0019904; GO:0030154; GO:0030838; GO:0031623; GO:0038095; GO:0042770; GO:0042802; GO:0043408; GO:0043560; GO:0044822; GO:0046875; GO:0048646; GO:0051291; GO:0060670; GO:0070062; GO:0070436; GO:0071479; GO:2000379 0 0 0 PF00017;PF00018; Q6PFY8 CHOYP_BRAFLDRAFT_93856.5.6 m.39913 sp TRI45_MOUSE 31.683 202 116 8 5 193 127 319 3.77E-12 72.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PFY8 CHOYP_LOC100372847.4.4 m.55181 sp TRI45_MOUSE 22.222 198 122 5 28 209 191 372 3.77E-06 53.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7Z0T3 CHOYP_TEMPT.3.3 m.40304 sp TEMPT_APLCA 35.659 129 69 5 45 168 4 123 3.77E-13 66.6 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q86WB7 CHOYP_UN93A.3.3 m.52926 sp UN93A_HUMAN 27.533 454 299 10 93 535 6 440 3.77E-47 174 UN93A_HUMAN reviewed Protein unc-93 homolog A (HmUnc-93A) (Unc-93A) UNC93A Homo sapiens (Human) 457 0 GO:0005886; GO:0016021 0 0 cd06174; PF05978; Q8BMG8 CHOYP_LOC100648519.1.1 m.62697 sp MFTC_MOUSE 54.704 287 122 3 18 304 17 295 3.77E-106 316 MFTC_MOUSE reviewed Mitochondrial folate transporter/carrier (Solute carrier family 25 member 32) Slc25a32 Mftc Mus musculus (Mouse) 316 glycine metabolic process [GO:0006544]; translation [GO:0006412]; transport [GO:0006810] GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0006544; GO:0006810; GO:0016021 0 0 0 PF00153; Q8C4U2 CHOYP_BRAFLDRAFT_284772.1.1 m.4770 sp TM145_MOUSE 48.8 125 64 0 18 142 276 400 3.77E-39 142 TM145_MOUSE reviewed Transmembrane protein 145 Tmem145 Mus musculus (Mouse) 746 G-protein coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] GO:0007186; GO:0016021; GO:0019236 0 0 0 PF10192; Q99NH0 CHOYP_LOC753709.41.44 m.64121 sp ANR17_MOUSE 33.792 509 316 16 224 713 203 709 3.77E-60 224 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BZP6 CHOYP_CHIA.1.3 m.165 sp CHIA_HUMAN 51.417 247 106 3 170 409 16 255 3.77E-84 268 CHIA_HUMAN reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (Lung-specific protein TSA1902) CHIA Homo sapiens (Human) 476 apoptotic process [GO:0006915]; carbohydrate metabolic process [GO:0005975]; cell wall chitin metabolic process [GO:0006037]; chitin catabolic process [GO:0006032]; chitin metabolic process [GO:0006030]; digestion [GO:0007586]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532]; response to fungus [GO:0009620] GO:0000272; GO:0002532; GO:0003796; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0005975; GO:0006030; GO:0006032; GO:0006037; GO:0006915; GO:0006955; GO:0007586; GO:0008061; GO:0009620; GO:0019900; GO:0030246; GO:0090197 0 0 0 PF01607;PF00704; Q9CZV5 CHOYP_ST65G.1.1 m.23879 sp ST65G_MOUSE 37.534 373 199 14 8 355 5 368 3.77E-56 192 ST65G_MOUSE reviewed STAGA complex 65 subunit gamma (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like) Supt7l Mus musculus (Mouse) 412 "histone H3 acetylation [GO:0043966]; maintenance of protein location in nucleus [GO:0051457]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0004402; GO:0005634; GO:0006351; GO:0006355; GO:0030914; GO:0043966; GO:0051457 0 0 0 PF07524; Q9GKS9 CHOYP_LOC100366424.1.1 m.29609 sp DZAN1_MACFA 40.719 334 178 6 293 614 263 588 3.77E-71 244 DZAN1_MACFA reviewed Double zinc ribbon and ankyrin repeat-containing protein 1 DZANK1 QccE-20932 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 606 0 GO:0046872 0 0 0 PF12773; Q9NS93 CHOYP_BRAFLDRAFT_284225.1.1 m.24686 sp TM7S3_HUMAN 29.412 527 342 9 86 591 52 569 3.77E-70 240 TM7S3_HUMAN reviewed Transmembrane 7 superfamily member 3 (Seven span transmembrane protein) TM7SF3 Homo sapiens (Human) 570 0 GO:0005886; GO:0016021; GO:0070062 0 0 0 PF13886; Q9R1R2 CHOYP_contig_028938 m.32868 sp TRIM3_MOUSE 25 152 110 3 23 171 593 743 3.77E-08 55.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A1L162 CHOYP_BRAFLDRAFT_74793.1.2 m.16718 sp ERIC2_HUMAN 44.565 92 49 2 174 265 64 153 3.78E-13 68.9 ERIC2_HUMAN reviewed Glutamate-rich protein 2 ERICH2 Homo sapiens (Human) 156 0 0 0 0 0 0 A5PJZ2 CHOYP_LOC100377829.1.2 m.9290 sp PPM1L_BOVIN 72.65 117 32 0 74 190 235 351 3.78E-56 184 PPM1L_BOVIN reviewed Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) PPM1L PP2CE Bos taurus (Bovine) 360 MAPK cascade [GO:0000165]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178] GO:0000165; GO:0004722; GO:0005622; GO:0007178; GO:0016021; GO:0046872; GO:0070062 0 0 0 PF00481; B3EWZ5 CHOYP_CJ112.1.2 m.19 sp MLRP1_ACRMI 31.496 254 149 10 1 235 1205 1452 3.78E-31 124 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O43312 CHOYP_MTSS1.1.1.1 m.41595 sp MTSS1_HUMAN 60.831 337 120 4 1 332 1 330 3.78E-123 391 MTSS1_HUMAN reviewed Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) 755 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; movement of cell or subcellular component [GO:0006928]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of defense response to virus by host [GO:0002230]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; xenophagy [GO:0098792] GO:0001726; GO:0002230; GO:0003785; GO:0005102; GO:0005737; GO:0006928; GO:0007009; GO:0007155; GO:0007169; GO:0015629; GO:0030035; GO:0030036; GO:0030139; GO:0042802; GO:0050680; GO:0061333; GO:0071498; GO:0072102; GO:0072160; GO:0098792; GO:2001013 0 0 0 PF08397;PF02205; O57476 CHOYP_BRAFLDRAFT_115687.1.1 m.4876 sp CDC37_CHICK 58.046 348 138 1 4 343 2 349 3.78E-141 409 CDC37_CHICK reviewed Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) CDC37 Gallus gallus (Chicken) 393 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005737; GO:0006457; GO:0031072; GO:0050821; GO:0051082; GO:0051087 0 0 0 PF08564;PF08565;PF03234; O88974 CHOYP_LOC100372058.2.2 m.42486 sp SETB1_MOUSE 35.593 944 504 27 90 969 24 927 3.78E-158 511 SETB1_MOUSE reviewed Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (SET domain bifurcated 1) Setdb1 Eset Kiaa0067 Mus musculus (Mouse) 1307 "bone development [GO:0060348]; histone H3-K9 trimethylation [GO:0036124]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; Ras protein signal transduction [GO:0007265]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001833; GO:0003677; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005886; GO:0006351; GO:0007265; GO:0008270; GO:0018024; GO:0036124; GO:0043231; GO:0060348; GO:0090309; GO:1990841 0 0 0 PF01429;PF05033;PF00856; P12001 CHOYP_LOC100560334.2.3 m.42998 sp RL18_RAT 73.714 175 46 0 16 190 1 175 3.78E-94 275 RL18_RAT reviewed 60S ribosomal protein L18 Rpl18 Rattus norvegicus (Rat) 188 liver regeneration [GO:0097421]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0097421 0 0 0 PF17135; P25666 CHOYP_contig_011972 m.13741 sp HTRL_ECOLI 25.403 248 164 11 106 338 4 245 3.78E-07 54.7 HTRL_ECOLI reviewed Protein HtrL htrL yibB b3618 JW5644 Escherichia coli (strain K12) 285 lipopolysaccharide biosynthetic process [GO:0009103] GO:0009103 0 0 0 PF09612; P36241 CHOYP_contig_043163 m.49822 sp RL19_DROME 78.289 152 33 0 1 152 15 166 3.78E-82 245 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; Q13948 CHOYP_CUX1.1.2 m.10448 sp CASP_HUMAN 53.711 512 208 6 1 507 1 488 3.78E-161 502 CASP_HUMAN reviewed Protein CASP CUX1 CUTL1 Homo sapiens (Human) 678 intra-Golgi vesicle-mediated transport [GO:0006891] GO:0000139; GO:0005654; GO:0005794; GO:0006891; GO:0030173 0 0 0 PF08172; Q5ZMG5 CHOYP_BRAFLDRAFT_117401.1.3 m.12818 sp AROS_CHICK 29.655 145 90 5 1 140 1 138 3.78E-08 52 AROS_CHICK reviewed Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP) RPS19BP1 AROS RCJMB04_2b23 Gallus gallus (Chicken) 140 0 GO:0005654; GO:0005730 0 0 0 PF15684; Q5ZMG5 CHOYP_DCAF5.1.1 m.39735 sp AROS_CHICK 29.655 145 90 5 1 140 1 138 3.78E-08 52 AROS_CHICK reviewed Active regulator of SIRT1 (40S ribosomal protein S19-binding protein 1) (RPS19-binding protein 1) (S19BP) RPS19BP1 AROS RCJMB04_2b23 Gallus gallus (Chicken) 140 0 GO:0005654; GO:0005730 0 0 0 PF15684; Q60769 CHOYP_BRAFLDRAFT_132229.1.1 m.63738 sp TNAP3_MOUSE 24.935 774 434 23 96 790 35 740 3.78E-50 194 TNAP3_MOUSE reviewed Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 3.4.19.12) (EC 6.3.2.-) (Putative DNA-binding protein A20) (Zinc finger protein A20) Tnfaip3 Tnfip3 Mus musculus (Mouse) 775 apoptotic process [GO:0006915]; B-1 B cell homeostasis [GO:0001922]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to lipopolysaccharide [GO:0071222]; establishment of protein localization to vacuole [GO:0072666]; inflammatory response [GO:0006954]; marginal zone B cell differentiation [GO:0002315]; negative regulation of autophagy [GO:0010507]; negative regulation of B cell activation [GO:0050869]; negative regulation of CD40 signaling pathway [GO:2000349]; negative regulation of cell death [GO:0060548]; negative regulation of chronic inflammatory response [GO:0002677]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of granuloma formation [GO:0002632]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070429]; negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of toll-like receptor 5 signaling pathway [GO:0034148]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of protein catabolic process [GO:0045732]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked deubiquitination [GO:0070536]; regulation of germinal center formation [GO:0002634]; regulation of immunoglobulin production [GO:0002637]; regulation of innate immune response [GO:0045088]; response to molecule of bacterial origin [GO:0002237]; response to muramyl dipeptide [GO:0032495]; response to wounding [GO:0009611]; tolerance induction to lipopolysaccharide [GO:0072573] GO:0001922; GO:0002020; GO:0002237; GO:0002315; GO:0002632; GO:0002634; GO:0002637; GO:0002677; GO:0003677; GO:0004842; GO:0004843; GO:0005634; GO:0005737; GO:0005764; GO:0006915; GO:0006954; GO:0008270; GO:0009611; GO:0010507; GO:0016579; GO:0016874; GO:0019900; GO:0031397; GO:0032088; GO:0032495; GO:0032691; GO:0032703; GO:0032715; GO:0032720; GO:0034115; GO:0034140; GO:0034148; GO:0035871; GO:0043124; GO:0043130; GO:0043621; GO:0045088; GO:0045732; GO:0045736; GO:0045824; GO:0048662; GO:0050728; GO:0050869; GO:0060548; GO:0070062; GO:0070301; GO:0070429; GO:0070433; GO:0070530; GO:0070536; GO:0070936; GO:0071108; GO:0071222; GO:0071947; GO:0072573; GO:0072666; GO:1902042; GO:1903364; GO:2000347; GO:2000349; GO:2000352 0 0 0 PF02338;PF01754; Q6DIB5 CHOYP_MEG10.26.91 m.33830 sp MEG10_MOUSE 39.13 391 208 18 1 382 331 700 3.78E-59 211 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q86XE3 CHOYP_contig_005243 m.5980 sp MICU3_HUMAN 47.664 107 56 0 63 169 129 235 3.78E-21 93.2 MICU3_HUMAN reviewed "Calcium uptake protein 3, mitochondrial (EF-hand domain-containing family member A2)" MICU3 EFHA2 Homo sapiens (Human) 530 0 GO:0005509; GO:0005739; GO:0016021 0 0 0 PF13833; Q8C6L5 CHOYP_CGAS.1.6 m.19073 sp CGAS_MOUSE 27.982 218 142 9 209 420 161 369 3.78E-08 58.9 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8WQ47 CHOYP_TBA1.6.9 m.40284 sp TBA_LEPDS 96.226 106 4 0 44 149 76 181 3.78E-68 216 TBA_LEPDS reviewed Tubulin alpha chain (allergen Lep d ?) 0 Lepidoglyphus destructor (Storage mite) (Glycyphagus destructor) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q969X6 CHOYP_CIR1A.1.1 m.11568 sp UTP4_HUMAN 36.744 694 409 12 29 700 1 686 3.78E-149 452 UTP4_HUMAN reviewed U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component) UTP4 CIRH1A cPERP-E KIAA1988 Homo sapiens (Human) 686 "maturation of SSU-rRNA [GO:0030490]; regulation of transcription, DNA-templated [GO:0006355]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0001650; GO:0005654; GO:0005694; GO:0005730; GO:0006351; GO:0006355; GO:0006364; GO:0030490; GO:0034455; GO:0044822 0 0 0 PF00400; Q9BWU0 CHOYP_LOC101169402.1.1 m.7122 sp NADAP_HUMAN 50.562 445 196 13 121 549 151 587 3.78E-126 398 NADAP_HUMAN reviewed Kanadaptin (Human lung cancer oncogene 3 protein) (HLC-3) (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) SLC4A1AP HLC3 Homo sapiens (Human) 796 0 GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0043231 0 0 0 PF00035;PF00498; Q9CPY6 CHOYP_LOC100642891.1.1 m.25639 sp GID4_MOUSE 79.899 199 40 0 3 201 19 217 3.78E-125 355 GID4_MOUSE reviewed Glucose-induced degradation protein 4 homolog (Vacuolar import and degradation protein 24 homolog) Gid4 Mus musculus (Mouse) 217 0 0 0 0 0 PF09783; Q9NFT7 CHOYP_DERE_GG18317.1.1 m.44727 sp HXK2_DROME 48.998 449 220 5 13 456 41 485 3.78E-147 431 HXK2_DROME reviewed Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) 486 cellular glucose homeostasis [GO:0001678]; fructose metabolic process [GO:0006000]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; mannose metabolic process [GO:0006013] GO:0001678; GO:0004340; GO:0004396; GO:0005524; GO:0005536; GO:0005829; GO:0006000; GO:0006006; GO:0006013; GO:0006096; GO:0008865; GO:0019158 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF00349;PF03727; Q9NGX9 CHOYP_BRAFLDRAFT_91871.1.3 m.929 sp CP302_DROME 29.582 311 201 7 40 345 19 316 3.78E-34 135 CP302_DROME reviewed "Cytochrome P450 302a1, mitochondrial (EC 1.14.99.-) (Protein disembodied)" dib CYP302A1 CG12028 Drosophila melanogaster (Fruit fly) 489 central nervous system development [GO:0007417]; chitin-based embryonic cuticle biosynthetic process [GO:0008362]; dorsal closure [GO:0007391]; ecdysone biosynthetic process [GO:0006697]; head involution [GO:0008258]; midgut development [GO:0007494] GO:0005506; GO:0005739; GO:0006697; GO:0007391; GO:0007417; GO:0007494; GO:0008258; GO:0008362; GO:0009055; GO:0016705; GO:0020037; GO:0031966; GO:0042767 PATHWAY: Steroid biosynthesis; ecdysteroid biosynthesis. {ECO:0000269|PubMed:14610274}. 0 0 PF00067; Q9V4M2 CHOYP_CCD73.1.2 m.21485 sp WECH_DROME 23.556 225 140 6 224 429 499 710 3.78E-06 53.1 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; A0A0N9E2K8 CHOYP_MMP21.1.1 m.41772 sp MMP21_DANRE 35.921 657 308 21 23 651 19 590 3.79E-117 365 MMP21_DANRE reviewed Matrix metallopeptidase-21 (MMP-21) (EC 3.4.24.-) mmp21 Danio rerio (Zebrafish) (Brachydanio rerio) 599 determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368] GO:0004222; GO:0005509; GO:0007368; GO:0008270; GO:0031012; GO:0061371 0 0 cd04278; PF00045;PF00413;PF01471; A3KPN8 CHOYP_TTC38.1.1 m.27111 sp TTC38_DANRE 37.862 449 269 5 9 447 10 458 3.79E-100 310 TTC38_DANRE reviewed Tetratricopeptide repeat protein 38 (TPR repeat protein 38) ttc38 si:ch211-249g22.2 zgc:112407 Danio rerio (Zebrafish) (Brachydanio rerio) 466 0 0 0 0 0 0 A7MBH5 CHOYP_LOC100367974.2.3 m.50217 sp CC151_BOVIN 27.708 480 335 6 19 486 69 548 3.79E-37 148 CC151_BOVIN reviewed Coiled-coil domain-containing protein 151 CCDC151 Bos taurus (Bovine) 621 cilium movement [GO:0003341]; determination of left/right symmetry [GO:0007368]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017] GO:0003341; GO:0005814; GO:0005929; GO:0005930; GO:0007368; GO:0036064; GO:0036158; GO:1902017 0 0 0 0 C6KFA3 CHOYP_LOC100370403.1.1 m.11269 sp GP126_DANRE 29.467 750 425 26 390 1106 465 1143 3.79E-77 281 GP126_DANRE reviewed G-protein coupled receptor 126 gpr126 Danio rerio (Zebrafish) (Brachydanio rerio) 1185 cAMP-mediated signaling [GO:0019933]; cell surface receptor signaling pathway [GO:0007166]; ear development [GO:0043583]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; mitochondrion organization [GO:0007005]; myelination [GO:0042552]; myelination in peripheral nervous system [GO:0022011]; myelination of posterior lateral line nerve axons [GO:0048932]; ossification [GO:0001503]; peripheral nervous system myelin formation [GO:0032290]; regulation of sprouting angiogenesis [GO:1903670]; semicircular canal fusion [GO:0060879] GO:0001503; GO:0004930; GO:0005518; GO:0005622; GO:0005886; GO:0007005; GO:0007166; GO:0007186; GO:0007507; GO:0016021; GO:0019933; GO:0022011; GO:0032290; GO:0042552; GO:0043583; GO:0048932; GO:0050840; GO:0060347; GO:0060879; GO:1903670 0 0 0 PF00002;PF00431;PF01825;PF00354; H2A0M7 CHOYP_LOC100123937.1.1 m.7549 sp PLSP_PINMG 36.379 602 349 13 125 702 143 734 3.79E-108 350 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O17320 CHOYP_KPBB.2.2 m.46101 sp ACT_CRAGI 94.382 89 5 0 1 89 1 89 3.79E-56 183 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O43301 CHOYP_BRAFLDRAFT_208436.5.32 m.31407 sp HS12A_HUMAN 31.013 632 354 19 165 728 56 673 3.79E-82 278 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75886 CHOYP_LOC100373138.1.1 m.23491 sp STAM2_HUMAN 44.128 562 254 16 1 539 1 525 3.79E-137 410 STAM2_HUMAN reviewed Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) STAM2 HBP Homo sapiens (Human) 525 autophagy [GO:0006914]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059] GO:0005654; GO:0005737; GO:0005829; GO:0006886; GO:0006914; GO:0016197; GO:0031901; GO:0033565; GO:0036258; GO:0042059; GO:0043231 0 0 0 PF00018;PF02809;PF00790; P42858 CHOYP_HTT.1.1 m.33803 sp HD_HUMAN 34.805 974 548 21 388 1317 519 1449 3.79E-163 546 HD_HUMAN reviewed Huntingtin (Huntington disease protein) (HD protein) HTT HD IT15 Homo sapiens (Human) 3142 "animal organ development [GO:0048513]; apoptotic process [GO:0006915]; central nervous system development [GO:0007417]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; mRNA transport [GO:0051028]; negative regulation of cysteine-type endopeptidase activity [GO:2000117]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cilium assembly [GO:0045724]; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031587]; regulation of protein phosphatase type 2A activity [GO:0034047]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle transport along microtubule [GO:0047496]; vocal learning [GO:0042297]" GO:0000132; GO:0002039; GO:0005522; GO:0005634; GO:0005654; GO:0005737; GO:0005770; GO:0005776; GO:0005783; GO:0005794; GO:0005814; GO:0005829; GO:0006890; GO:0006915; GO:0007030; GO:0007417; GO:0008134; GO:0014069; GO:0030136; GO:0030424; GO:0030425; GO:0030659; GO:0031587; GO:0034047; GO:0034452; GO:0042297; GO:0042802; GO:0043025; GO:0043234; GO:0044325; GO:0045505; GO:0045724; GO:0047496; GO:0048487; GO:0048513; GO:0051028; GO:0071598; GO:2000117; GO:2001237 0 0 0 PF12372; P48725 CHOYP_LOC582174.1.16 m.977 sp PCNT_MOUSE 42.246 187 99 4 47 227 2683 2866 3.79E-34 132 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; P49109 CHOYP_LOC578464.1.1 m.46553 sp FMO5_CAVPO 35.913 504 286 14 16 502 6 489 3.79E-91 291 FMO5_CAVPO reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; P49395 CHOYP_RS3A.2.15 m.2682 sp RS3A_APLCA 81.328 241 42 1 15 252 21 261 3.79E-146 413 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P57760 CHOYP_DCTN2.1.1 m.1085 sp STK16_RAT 40.357 280 155 4 1 279 23 291 3.79E-75 234 STK16_RAT reviewed Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) Stk16 Mpsk1 Tsf1 Rattus norvegicus (Rat) 305 cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777] GO:0001077; GO:0004672; GO:0004674; GO:0004715; GO:0005524; GO:0005737; GO:0005798; GO:0016020; GO:0045944; GO:0046777; GO:0048471; GO:0071560 0 0 0 PF00069; P61857 CHOYP_LOC101061694.1.1 m.49906 sp TBB2_DROME 48.684 76 25 3 1 76 164 225 3.79E-09 55.5 TBB2_DROME reviewed Tubulin beta-2 chain (Beta-2-tubulin) betaTub85D TubB85D CG9359 Drosophila melanogaster (Fruit fly) 446 microtubule-based process [GO:0007017]; salivary gland morphogenesis [GO:0007435] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0007435 0 0 0 PF00091;PF03953; P83565 CHOYP_CPIPJ_CPIJ008492.1.1 m.6934 sp RM40_RAT 35.329 167 102 2 54 220 39 199 3.79E-25 100 RM40_RAT reviewed "39S ribosomal protein L40, mitochondrial (L40mt) (MRP-L40)" Mrpl40 Rattus norvegicus (Rat) 206 0 GO:0005730; GO:0005761; GO:0044822 0 0 0 PF09812; Q0E908 CHOYP_LOC100901500.1.3 m.15241 sp HIL_DROME 26.627 507 310 14 43 508 333 818 3.79E-46 180 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q12955 CHOYP_LOC583072.8.25 m.37632 sp ANK3_HUMAN 36.25 320 193 3 100 414 42 355 3.79E-56 203 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q18359 CHOYP_NDUA5.1.2 m.2750 sp NDUA5_CAEEL 45.455 110 60 0 8 117 40 149 3.79E-31 110 NDUA5_CAEEL reviewed Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 C33A12.1 Caenorhabditis elegans 150 respiratory electron transport chain [GO:0022904] GO:0005747; GO:0016651; GO:0022904 0 0 0 PF04716; Q24524 CHOYP_FSCN1A.1.1 m.48680 sp SING_DROME 34.898 490 291 14 9 487 25 497 3.79E-86 277 SING_DROME reviewed Protein singed sn CG1536 Drosophila melanogaster (Fruit fly) 512 actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; chaeta morphogenesis [GO:0008407]; cuticle pattern formation [GO:0035017]; dendrite development [GO:0016358]; epidermal cell differentiation [GO:0009913]; establishment or maintenance of cell polarity [GO:0007163]; filopodium assembly [GO:0046847]; hemocyte migration [GO:0035099]; imaginal disc-derived wing hair organization [GO:0035317]; microvillar actin bundle assembly [GO:0030034]; neuron projection morphogenesis [GO:0048812]; oogenesis [GO:0048477]; wound healing [GO:0042060] GO:0003779; GO:0005737; GO:0007015; GO:0007163; GO:0008407; GO:0009913; GO:0015629; GO:0016358; GO:0030034; GO:0030036; GO:0035017; GO:0035099; GO:0035317; GO:0042060; GO:0043005; GO:0043025; GO:0046847; GO:0048477; GO:0048800; GO:0048812; GO:0051015; GO:0051017 0 0 0 PF06268; Q2TBX6 CHOYP_PSB1.1.2 m.5628 sp PSB1_BOVIN 64.55 189 66 1 11 199 10 197 3.79E-82 247 PSB1_BOVIN reviewed Proteasome subunit beta type-1 (EC 3.4.25.1) PSMB1 Bos taurus (Bovine) 241 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0051603 0 0 0 PF00227; Q501Z5 CHOYP_BRAFLDRAFT_125232.1.1 m.18752 sp GTPB3_DANRE 60.323 310 121 1 38 347 33 340 3.79E-132 389 GTPB3_DANRE reviewed "tRNA modification GTPase GTPBP3, mitochondrial (GTP-binding protein 3)" gtpbp3 zgc:112394 Danio rerio (Zebrafish) (Brachydanio rerio) 500 tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] GO:0002098; GO:0003924; GO:0005525; GO:0005739; GO:0030488 0 0 cd04164; PF01926;PF12631;PF10396; Q5SZI1 CHOYP_BRAFLDRAFT_124864.2.2 m.66692 sp LRAD2_HUMAN 31.313 99 57 5 107 200 113 205 3.79E-07 53.5 LRAD2_HUMAN reviewed Low-density lipoprotein receptor class A domain-containing protein 2 LDLRAD2 Homo sapiens (Human) 272 0 GO:0016021 0 0 0 PF00057; Q5ZKW0 CHOYP_MTU1.1.2 m.37323 sp MTU1_CHICK 50.617 405 174 4 5 385 2 404 3.79E-138 403 MTU1_CHICK reviewed Mitochondrial tRNA-specific 2-thiouridylase 1 (EC 2.8.1.14) TRMU MTU1 RCJMB04_8p20 Gallus gallus (Chicken) 424 mitochondrial tRNA thio-modification [GO:0070903]; tRNA wobble position uridine thiolation [GO:0002143] GO:0000049; GO:0002143; GO:0005524; GO:0005739; GO:0016783; GO:0070903 0 0 cd01998; 0 Q5ZLG9 CHOYP_WDR59.1.5 m.4505 sp WDR59_CHICK 47.423 97 51 0 37 133 837 933 3.79E-27 109 WDR59_CHICK reviewed WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) 973 cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034198; GO:0061700 0 0 0 PF00400; Q5ZQU0 CHOYP_SERR.1.1 m.41956 sp SNED1_RAT 27.545 334 175 15 42 343 628 926 3.79E-11 70.1 SNED1_RAT reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" Sned1 Rattus norvegicus (Rat) 1403 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00008;PF00041;PF12661;PF06119; Q717R8 CHOYP_LOC100199066.1.1 m.19898 sp EF1D_SHEEP 34.008 247 117 7 7 238 6 221 3.79E-30 116 EF1D_SHEEP reviewed Elongation factor 1-delta (EF-1-delta) EEF1D Ovis aries (Sheep) 277 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; Q865K9 CHOYP_PAQR8.2.2 m.49960 sp MPRB_PIG 34.219 301 194 4 1 300 9 306 3.79E-53 181 MPRB_PIG reviewed Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ receptor family member VIII) PAQR8 MPRB Sus scrofa (Pig) 354 multicellular organism development [GO:0007275]; oogenesis [GO:0048477]; response to steroid hormone [GO:0048545] GO:0003707; GO:0005496; GO:0005886; GO:0007275; GO:0016021; GO:0048477; GO:0048545 0 0 0 PF03006; Q8HY00 CHOYP_CD209.3.6 m.40586 sp CD209_PONPY 36.943 157 86 7 41 194 235 381 3.79E-21 92.8 CD209_PONPY reviewed CD209 antigen (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN1) (CD antigen CD209) CD209 Pongo pygmaeus (Bornean orangutan) 404 adaptive immune response [GO:0002250]; cell adhesion [GO:0007155]; endocytosis [GO:0006897]; innate immune response [GO:0045087] GO:0002250; GO:0005537; GO:0006897; GO:0007155; GO:0016021; GO:0045087; GO:0046872 0 0 0 PF00059; Q8NA69 CHOYP_BRAFLDRAFT_125998.1.1 m.63211 sp CS045_HUMAN 22.986 509 337 17 1 484 1 479 3.79E-11 68.9 CS045_HUMAN reviewed Uncharacterized protein C19orf45 C19orf45 Homo sapiens (Human) 505 0 0 0 0 0 PF15373; Q95SX7 CHOYP_LOC100892567.6.8 m.42827 sp RTBS_DROME 23.13 869 585 24 212 1031 4 838 3.79E-34 145 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q9NUV9 CHOYP_LOC100016673.1.1 m.31828 sp GIMA4_HUMAN 37.398 246 145 3 259 497 22 265 3.79E-47 169 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9U518 CHOYP_ASPG.1.2 m.33731 sp ASPG_DIRIM 50 500 243 4 10 506 6 501 3.79E-167 488 ASPG_DIRIM reviewed L-asparaginase (EC 3.5.1.1) (DiAsp) (L-asparagine amidohydrolase) 0 Dirofilaria immitis (Canine heartworm) 590 asparagine metabolic process [GO:0006528] GO:0004067; GO:0006528 0 0 0 PF00710; A2VDN6 CHOYP_LOC100376668.1.1 m.63419 sp SF3A1_BOVIN 68.376 117 37 0 18 134 677 793 3.80E-49 170 SF3A1_BOVIN reviewed Splicing factor 3A subunit 1 SF3A1 Bos taurus (Bovine) 793 "mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000381; GO:0000389; GO:0000398; GO:0003723; GO:0005654; GO:0005684; GO:0005686; GO:0044822; GO:0071004; GO:0071013 0 0 0 PF12230;PF01805;PF00240; P02553 CHOYP_TBA1.4.9 m.14943 sp TBA_LYTPI 90.217 92 8 1 68 158 70 161 3.80E-53 168 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P31674 CHOYP_ISCW_ISCW016148.6.6 m.66477 sp RS15_ORYSJ 81.395 129 24 0 15 143 17 145 3.80E-72 221 RS15_ORYSJ reviewed 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) 154 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00203; P40983 CHOYP_TRIADDRAFT_54952.2.2 m.48585 sp YOR6_CALSR 29.63 162 82 6 54 207 43 180 3.80E-08 59.7 YOR6_CALSR reviewed Uncharacterized protein in xynA 3'region (ORF6) (Fragment) 0 Caldicellulosiruptor sp. (strain Rt8B.4) 402 0 0 0 0 0 PF00350; P97864 CHOYP_CASP7.19.23 m.61733 sp CASP7_MOUSE 27.559 254 146 12 17 251 67 301 3.80E-17 82.4 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q04781 CHOYP_LOC101214299.1.1 m.11024 sp LTN1_YEAST 44.444 54 23 2 129 176 1507 1559 3.80E-06 50.1 LTN1_YEAST reviewed E3 ubiquitin-protein ligase listerin (EC 6.3.2.-) (RING domain mutant killed by rtf1 deletion protein 1) RKR1 LTN1 YMR247C YM9408.09C YM9920.01C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1562 chromatin modification [GO:0016568]; chromatin silencing at telomere [GO:0006348]; proteasomal protein catabolic process [GO:0010498]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]; ribosome-associated ubiquitin-dependent protein catabolic process [GO:1990116]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000781; GO:0004842; GO:0005634; GO:0006348; GO:0006511; GO:0008270; GO:0010498; GO:0016567; GO:0016568; GO:0016874; GO:0043023; GO:0072344; GO:1990112; GO:1990116 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q14149 CHOYP_MORC3.1.2 m.38178 sp MORC3_HUMAN 52.423 454 190 11 1 444 45 482 3.80E-142 444 MORC3_HUMAN reviewed MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) MORC3 KIAA0136 NXP2 ZCWCC3 Homo sapiens (Human) 939 cell aging [GO:0007569]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of fibroblast proliferation [GO:0048147]; peptidyl-serine phosphorylation [GO:0018105]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; viral process [GO:0016032] GO:0003723; GO:0005654; GO:0006468; GO:0007569; GO:0008270; GO:0009791; GO:0016032; GO:0016363; GO:0016605; GO:0018105; GO:0048147; GO:0050821; GO:0051457 0 0 0 PF07496; Q14181 CHOYP_LOC100372955.1.1 m.18209 sp DPOA2_HUMAN 43.019 616 325 11 42 654 6 598 3.80E-157 468 DPOA2_HUMAN reviewed DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) POLA2 Homo sapiens (Human) 598 "DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; G1/S transition of mitotic cell cycle [GO:0000082]; protein import into nucleus, translocation [GO:0000060]; telomere maintenance via recombination [GO:0000722]" GO:0000060; GO:0000082; GO:0000722; GO:0003677; GO:0003887; GO:0005654; GO:0005658; GO:0005737; GO:0006260; GO:0006270; GO:0006271; GO:0046982 0 0 0 PF04042;PF08418; Q16I17 CHOYP_MTNA.1.1 m.1717 sp MTNA_AEDAE 62.254 355 132 2 19 372 1 354 3.80E-155 444 MTNA_AEDAE reviewed Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) AAEL013828 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 360 L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; L-methionine biosynthetic process from S-adenosylmethionine [GO:0019284] GO:0005634; GO:0005737; GO:0019284; GO:0019509; GO:0046523 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. {ECO:0000255|HAMAP-Rule:MF_03119}. 0 0 PF01008; Q23445 CHOYP_SAR1.1.1 m.61669 sp SAR1_CAEEL 48.851 174 86 1 135 305 20 193 3.80E-54 177 SAR1_CAEEL reviewed GTP-binding protein SAR1 ZK180.4 Caenorhabditis elegans 193 embryo development ending in birth or egg hatching [GO:0009792]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005783; GO:0005794; GO:0006886; GO:0009792; GO:0016192 0 0 0 PF00025; Q24155 CHOYP_TRK.1.1 m.55655 sp TRUNK_DROME 28.421 95 61 1 221 308 128 222 3.80E-10 62.4 TRUNK_DROME reviewed Protein trunk trk CG5619 Drosophila melanogaster (Fruit fly) 226 "anterior/posterior axis specification, embryo [GO:0008595]; maternal determination of anterior/posterior axis, embryo [GO:0008358]; terminal region determination [GO:0007362]; torso signaling pathway [GO:0008293]" GO:0005122; GO:0005576; GO:0007362; GO:0008293; GO:0008358; GO:0008595 0 0 0 0 Q29HY3 CHOYP_CDC42.11.11 m.60004 sp CDC42_DROPS 93.194 191 13 0 1 191 1 191 3.80E-133 373 CDC42_DROPS reviewed Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) 191 maintenance of protein location [GO:0045185]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275; GO:0045185; GO:0045860 0 0 0 PF00071; Q32KR8 CHOYP_BRAFLDRAFT_212086.7.11 m.54006 sp ADPRH_BOVIN 58.763 194 79 1 2 194 159 352 3.80E-76 238 ADPRH_BOVIN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Bos taurus (Bovine) 353 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q3UMB5 CHOYP_BRAFLDRAFT_81769.1.1 m.33221 sp SMCR8_MOUSE 29.815 379 220 10 28 387 28 379 3.80E-37 154 SMCR8_MOUSE reviewed Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog Smcr8 Mus musculus (Mouse) 935 0 GO:0005654 0 0 0 0 Q460N3 CHOYP_LOC100770244.1.1 m.62649 sp PAR15_HUMAN 31.373 612 371 15 238 824 89 676 3.80E-76 264 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q4LDE5 CHOYP_NEMVEDRAFT_V1G202195.1.4 m.34288 sp SVEP1_HUMAN 30.058 173 117 4 395 566 991 1160 3.80E-13 77 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4R632 CHOYP_LOC580601.2.5 m.26941 sp CBPC2_MACFA 48.673 452 214 4 259 710 228 661 3.80E-144 459 CBPC2_MACFA reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) AGBL2 CCP2 QtsA-19251 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 840 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q5EB28 CHOYP_MIDN.1.3 m.2712 sp MIDN_XENTR 35.766 137 61 4 1 110 271 407 3.80E-16 77.4 MIDN_XENTR reviewed Midnolin (Midbrain nucleolar protein) midn TNeu058f14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 453 0 GO:0005730 0 0 0 PF00240; Q5R8X9 CHOYP_LOC752958.1.1 m.54890 sp AMN1_PONAB 44.531 256 139 2 14 269 6 258 3.80E-78 240 AMN1_PONAB reviewed Protein AMN1 homolog AMN1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 258 0 0 0 0 0 PF13516; Q5YLG1 CHOYP_NEMVEDRAFT_V1G83869.2.3 m.23803 sp GUNA_BACPU 42.733 461 238 10 344 787 46 497 3.80E-96 316 GUNA_BACPU reviewed "Endoglucanase A (EC 3.2.1.4) (Endo-1,4-beta-glucanase A)" eglA Bacillus pumilus (Bacillus mesentericus) 659 cellulose catabolic process [GO:0030245] GO:0005576; GO:0008810; GO:0030245; GO:0030248 0 0 0 PF00942;PF00759; Q62661 CHOYP_LOC100375095.2.2 m.36154 sp HBP1_RAT 38.71 434 184 15 150 529 100 505 3.80E-75 249 HBP1_RAT reviewed HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) Hbp1 Rattus norvegicus (Rat) 513 "positive regulation of potassium ion transport [GO:0043268]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355; GO:0016055; GO:0043268 0 0 0 PF08517;PF00505; Q6BEB4 CHOYP_BTD-LIKE.1.1 m.55893 sp SP5_HUMAN 54.299 221 60 6 143 323 176 395 3.80E-62 206 SP5_HUMAN reviewed Transcription factor Sp5 SP5 Homo sapiens (Human) 398 "bone morphogenesis [GO:0060349]; cellular response to organic cyclic compound [GO:0071407]; post-anal tail morphogenesis [GO:0036342]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0005634; GO:0006351; GO:0006355; GO:0036342; GO:0046872; GO:0060349; GO:0071407 0 0 0 PF00096; Q6PFY8 CHOYP_BRAFLDRAFT_63895.1.2 m.17529 sp TRI45_MOUSE 24.549 277 188 12 4 265 127 397 3.80E-10 64.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6ZWR6 CHOYP_BRAFLDRAFT_131050.1.1 m.18134 sp SYNE1_MOUSE 34.021 97 63 1 2 97 505 601 3.80E-08 55.1 SYNE1_MOUSE reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Syne1 Mus musculus (Mouse) 8799 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q8BXX2 CHOYP_LOC100706909.1.1 m.39750 sp ZBT49_MOUSE 32.642 193 101 4 1005 1171 387 576 3.80E-24 113 ZBT49_MOUSE reviewed Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Zbtb49 Zfp509 Znf509 Mus musculus (Mouse) 756 "cell cycle arrest [GO:0007050]; negative regulation of cell proliferation [GO:0008285]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0001223; GO:0005634; GO:0005737; GO:0006351; GO:0007050; GO:0008134; GO:0008285; GO:0043565; GO:0045944; GO:0046872 0 0 0 PF00651;PF00096;PF13912; Q99MK9 CHOYP_ISCW_ISCW007158.2.2 m.53689 sp RASF1_MOUSE 32.722 327 178 6 105 431 50 334 3.80E-55 190 RASF1_MOUSE reviewed Ras association domain-containing protein 1 (Protein 123F2) Rassf1 Mus musculus (Mouse) 340 cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of cell cycle arrest [GO:0071157]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; Ras protein signal transduction [GO:0007265]; regulation of microtubule cytoskeleton organization [GO:0070507] GO:0000922; GO:0005634; GO:0005737; GO:0005815; GO:0005874; GO:0005886; GO:0006974; GO:0007050; GO:0007265; GO:0015630; GO:0031398; GO:0046872; GO:0050821; GO:0070507; GO:0071157 0 0 0 PF00130;PF16517;PF00788; Q9JK81 CHOYP_MYG1.1.1 m.4971 sp MYG1_MOUSE 58.974 351 139 3 19 364 15 365 3.80E-150 431 MYG1_MOUSE reviewed "UPF0160 protein MYG1, mitochondrial (Protein Gamm1)" Myg1 Mus musculus (Mouse) 380 locomotory exploration behavior [GO:0035641] GO:0005634; GO:0005654; GO:0005739; GO:0035641; GO:0070062 0 0 0 PF03690; Q9R186 CHOYP_TRPV5.1.3 m.5267 sp TRPV6_RAT 29.289 239 136 9 89 327 119 324 3.80E-16 84.3 TRPV6_RAT reviewed Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) Trpv6 Rattus norvegicus (Rat) 767 calcium ion import [GO:0070509]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; protein homotetramerization [GO:0051289] GO:0005227; GO:0005262; GO:0005886; GO:0005887; GO:0016324; GO:0051289; GO:0070509; GO:0070588; GO:1990035 0 0 0 PF12796;PF00520; Q9R1R2 CHOYP_BRAFLDRAFT_205965.4.43 m.13234 sp TRIM3_MOUSE 24.516 155 111 3 39 191 593 743 3.80E-08 56.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UBV2 CHOYP_BRAFLDRAFT_220356.1.6 m.1057 sp SE1L1_HUMAN 57.509 273 111 3 62 330 171 442 3.80E-98 310 SE1L1_HUMAN reviewed Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L) SEL1L TSA305 UNQ128/PRO1063 Homo sapiens (Human) 794 "endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; triglyceride metabolic process [GO:0006641]" GO:0000836; GO:0000839; GO:0005783; GO:0005789; GO:0006641; GO:0007219; GO:0009306; GO:0016021; GO:0030433; GO:0030970; GO:0036503; GO:0036513; GO:0044322; GO:0050821; GO:1904380 0 0 cd00062; PF00040;PF08238; Q9UKD2 CHOYP_MRT4.1.1 m.1698 sp MRT4_HUMAN 61.818 220 83 1 1 219 1 220 3.80E-100 295 MRT4_HUMAN reviewed mRNA turnover protein 4 homolog (Ribosome assembly factor MRTO4) MRTO4 C1orf33 MRT4 Homo sapiens (Human) 239 nuclear-transcribed mRNA catabolic process [GO:0000956]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364] GO:0000027; GO:0000956; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0030687; GO:0031965; GO:0044822; GO:0070180 0 0 0 PF00466; A2AVA0 CHOYP_SVEP1.3.8 m.27352 sp SVEP1_MOUSE 51.724 145 70 0 2 146 1276 1420 3.81E-43 155 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A4IF63 CHOYP_BRAFLDRAFT_273508.4.4 m.61165 sp TRIM2_BOVIN 26.389 144 102 3 511 651 602 744 3.81E-07 57.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2A0N4 CHOYP_CFU_3729.1.2 m.11284 sp PIF_PINMG 29.022 317 180 9 1616 1902 238 539 3.81E-33 144 PIF_PINMG reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada margaritifera (Black-lipped pearl oyster) 1014 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607;PF00092; O43490 CHOYP_PROM1.3.3 m.58802 sp PROM1_HUMAN 24.872 784 540 20 56 802 55 826 3.81E-57 215 PROM1_HUMAN reviewed Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133) PROM1 PROML1 MSTP061 Homo sapiens (Human) 865 camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; glomerular visceral epithelial cell differentiation [GO:0072112]; photoreceptor cell maintenance [GO:0045494]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042] GO:0001750; GO:0005615; GO:0005783; GO:0005793; GO:0005886; GO:0005887; GO:0009986; GO:0010842; GO:0016324; GO:0031528; GO:0031982; GO:0042622; GO:0042805; GO:0043231; GO:0045296; GO:0045494; GO:0060042; GO:0060219; GO:0070062; GO:0072112; GO:0072139; GO:2000768 0 0 0 PF05478; O96647 CHOYP_BRAFLDRAFT_275426.2.2 m.25194 sp RL10_BOMMA 87.97 133 16 0 1 133 1 133 3.81E-83 246 RL10_BOMMA reviewed 60S ribosomal protein L10 (QM protein homolog) RpL10 Bombyx mandarina (Wild silk moth) (Wild silkworm) 219 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd01433; PF00252; P04323 CHOYP_LOC100377433.1.1 m.55304 sp POL3_DROME 34.875 281 180 2 18 295 267 547 3.81E-47 172 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P0C8E4 CHOYP_M3K7.4.4 m.19673 sp M3K7_RAT 46.617 133 68 1 12 144 473 602 3.81E-33 125 M3K7_RAT reviewed Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) Map3k7 Rattus norvegicus (Rat) 606 "activation of MAPKK activity [GO:0000186]; apoptotic process [GO:0006915]; I-kappaB phosphorylation [GO:0007252]; MAPK cascade [GO:0000165]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JUN kinase activity [GO:0043507]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000165; GO:0000186; GO:0000287; GO:0004709; GO:0005524; GO:0005622; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0007252; GO:0043123; GO:0043507 0 0 0 PF07714; P48441 CHOYP_IDUA.2.3 m.22579 sp IDUA_MOUSE 36.869 198 110 5 4 198 443 628 3.81E-34 130 IDUA_MOUSE reviewed Alpha-L-iduronidase (EC 3.2.1.76) Idua Mus musculus (Mouse) 634 carbohydrate metabolic process [GO:0005975]; cell morphogenesis [GO:0000902]; chemical homeostasis [GO:0048878]; dermatan sulfate catabolic process [GO:0030209]; limb morphogenesis [GO:0035108]; lysosome organization [GO:0007040]; skeletal system morphogenesis [GO:0048705] GO:0000902; GO:0003940; GO:0005764; GO:0005975; GO:0007040; GO:0030209; GO:0035108; GO:0048705; GO:0048878; GO:0070062 0 0 0 PF01229; Q03112 CHOYP_EVI1.1.1 m.62064 sp EVI1_HUMAN 49.505 303 112 8 81 344 121 421 3.81E-67 243 EVI1_HUMAN reviewed MDS1 and EVI1 complex locus protein EVI1 (Ecotropic virus integration site 1 protein homolog) (EVI-1) MECOM EVI1 Homo sapiens (Human) 1051 "apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; hematopoietic stem cell proliferation [GO:0071425]; negative regulation of JNK cascade [GO:0046329]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell cycle [GO:0051726]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006351; GO:0006915; GO:0016235; GO:0016607; GO:0018024; GO:0030154; GO:0042803; GO:0043069; GO:0043231; GO:0045892; GO:0045893; GO:0046329; GO:0046872; GO:0051726; GO:0071425 0 0 0 PF00096;PF13912; Q08170 CHOYP_SRSF4.2.6 m.10876 sp SRSF4_HUMAN 75.912 137 28 2 4 140 3 134 3.81E-59 193 SRSF4_HUMAN reviewed "Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)" SRSF4 SFRS4 SRP75 Homo sapiens (Human) 494 "mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000166; GO:0000375; GO:0000398; GO:0005634; GO:0005654; GO:0006369; GO:0006397; GO:0006405; GO:0006406; GO:0008380; GO:0016607; GO:0031124; GO:0044822; GO:0048025; GO:1990825 0 0 0 PF00076; Q0VA42 CHOYP_PHUM_PHUM075980.1.1 m.37380 sp F188B_XENTR 31.538 390 232 11 91 477 388 745 3.81E-50 185 F188B_XENTR reviewed Protein FAM188B fam188b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 746 0 0 0 0 0 PF13898; Q10576 CHOYP_P4HA1.5.5 m.67032 sp P4HA1_CAEEL 40.291 206 117 4 8 208 3 207 3.81E-39 144 P4HA1_CAEEL reviewed "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) (Protein dumpy-18)" dpy-18 phy-1 Y47D3B.10 Caenorhabditis elegans 559 collagen and cuticulin-based cuticle development [GO:0040002]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic body morphogenesis [GO:0010172]; macromolecule modification [GO:0043412]; oxidation-reduction process [GO:0055114]; peptidyl-proline hydroxylation [GO:0019511]; positive regulation of multicellular organism growth [GO:0040018] GO:0004656; GO:0005506; GO:0005623; GO:0005783; GO:0005788; GO:0009792; GO:0010172; GO:0016702; GO:0019511; GO:0031418; GO:0031545; GO:0040002; GO:0040018; GO:0043412; GO:0055114 0 0 0 PF13640;PF08336; Q5RD07 CHOYP_LOC100162572.1.1 m.23373 sp KCNK1_PONAB 43.023 258 140 5 25 279 37 290 3.81E-70 224 KCNK1_PONAB reviewed Potassium channel subfamily K member 1 KCNK1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 336 potassium ion transmembrane transport [GO:0071805]; regulation of resting membrane potential [GO:0060075]; sodium ion transmembrane transport [GO:0035725] GO:0005267; GO:0005272; GO:0005887; GO:0016021; GO:0016023; GO:0016324; GO:0022841; GO:0030054; GO:0030425; GO:0034705; GO:0035725; GO:0043204; GO:0045202; GO:0055037; GO:0060075; GO:0071805 0 0 0 PF07885; Q5RJH6 CHOYP_SMG7.1.1 m.21983 sp SMG7_MOUSE 41.333 525 290 8 4 524 5 515 3.81E-115 388 SMG7_MOUSE reviewed Protein SMG7 (EST1-like protein C) (SMG-7 homolog) Smg7 Est1c Kiaa0250 Mus musculus (Mouse) 1138 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" GO:0000184; GO:0005634; GO:0005737; GO:0042162; GO:0045111; GO:0051721 0 0 0 PF10374;PF10373; Q5TZA2 CHOYP_contig_036794 m.41413 sp CROCC_HUMAN 55.23 239 98 3 7 240 15 249 3.81E-66 224 CROCC_HUMAN reviewed Rootletin (Ciliary rootlet coiled-coil protein) CROCC KIAA0445 Homo sapiens (Human) 2017 cell cycle [GO:0007049]; centriole-centriole cohesion [GO:0010457]; centrosome organization [GO:0051297]; ciliary basal body organization [GO:0032053]; epithelial structure maintenance [GO:0010669]; establishment of organelle localization [GO:0051656]; photoreceptor cell maintenance [GO:0045494]; protein localization [GO:0008104]; protein localization to organelle [GO:0033365] GO:0001917; GO:0005198; GO:0005737; GO:0005813; GO:0005814; GO:0005886; GO:0007049; GO:0008104; GO:0010457; GO:0010669; GO:0015629; GO:0019894; GO:0032053; GO:0033365; GO:0035253; GO:0045494; GO:0051297; GO:0051656; GO:0070062 0 0 0 0 Q5UR67 CHOYP_CLOLE_3927.1.1 m.31405 sp RIBX_MIMIV 44.242 165 81 3 273 426 2 166 3.81E-32 123 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5VU97 CHOYP_NEMVEDRAFT_V1G238894.6.11 m.61040 sp CAHD1_HUMAN 26.034 411 267 16 3 389 666 1063 3.81E-29 125 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q5ZLC8 CHOYP_LOC100371176.1.1 m.33996 sp ANR52_CHICK 32.157 255 167 4 17 268 87 338 3.81E-25 109 ANR52_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ANKRD52 RCJMB04_6l3 Gallus gallus (Chicken) 1073 0 0 0 0 0 PF00023;PF12796; Q6PFY8 CHOYP_LOC100374819.2.7 m.48237 sp TRI45_MOUSE 25.379 264 164 7 3 254 79 321 3.81E-11 68.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6YV88 CHOYP_LOC100371043.4.5 m.34263 sp C71Z7_ORYSJ 31.967 122 73 2 15 126 8 129 3.81E-15 73.6 C71Z7_ORYSJ reviewed Ent-cassadiene C2-hydroxylase (EC 1.14.13.-) (Cytochrome P450 71Z7) CYP71Z7 Os02g0570700 LOC_Os02g36190 OsJ_07207 OSJNBa0008E01.37 P0689H05.7 Oryza sativa subsp. japonica (Rice) 518 diterpenoid biosynthetic process [GO:0016102]; oxidation-reduction process [GO:0055114]; secondary metabolite biosynthetic process [GO:0044550] GO:0005506; GO:0016020; GO:0016021; GO:0016102; GO:0016709; GO:0020037; GO:0044550; GO:0055114 0 0 0 PF00067; Q80VM9 CHOYP_LOC100869441.2.2 m.62049 sp OTOP1_MOUSE 22.083 480 268 13 232 621 130 593 3.81E-13 76.3 OTOP1_MOUSE reviewed Otopetrin-1 Otop1 Mus musculus (Mouse) 600 biomineral tissue development [GO:0031214]; detection of gravity [GO:0009590]; inner ear morphogenesis [GO:0042472] GO:0005615; GO:0009590; GO:0016020; GO:0016021; GO:0031214; GO:0042472 0 0 0 PF03189; Q86WV6 CHOYP_STING.3.3 m.61083 sp STING_HUMAN 34.239 184 111 6 544 719 154 335 3.81E-20 96.7 STING_HUMAN reviewed Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) 379 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of type I interferon production [GO:0032479]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005789; GO:0005794; GO:0005886; GO:0006915; GO:0008134; GO:0016021; GO:0019901; GO:0030659; GO:0032092; GO:0032479; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042802; GO:0042803; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; Q8BGC4 CHOYP_ZADH2.1.3 m.13137 sp ZADH2_MOUSE 53.239 355 160 4 3 354 26 377 3.81E-129 377 ZADH2_MOUSE reviewed Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-) Zadh2 Mus musculus (Mouse) 377 0 GO:0005739; GO:0005777; GO:0008270; GO:0016491 0 0 0 PF08240;PF00107; Q8BV42 CHOYP_ZN786.1.1 m.46495 sp ZN786_MOUSE 32.941 255 149 11 252 497 506 747 3.81E-25 114 ZN786_MOUSE reviewed Zinc finger protein 786 Znf786 Zfp786 Mus musculus (Mouse) 777 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352; Q8IW92 CHOYP_BRAFLDRAFT_114709.1.1 m.17347 sp GLBL2_HUMAN 45.336 611 310 9 10 616 46 636 3.81E-165 489 GLBL2_HUMAN reviewed Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) GLB1L2 MSTP014 UNQ210/PRO236 Homo sapiens (Human) 636 carbohydrate metabolic process [GO:0005975] GO:0004565; GO:0005576; GO:0005773; GO:0005975 0 0 0 PF01301; Q8K2Y0 CHOYP_RN219.3.3 m.19450 sp RN219_MOUSE 46.748 246 121 2 12 247 9 254 3.81E-68 233 RN219_MOUSE reviewed RING finger protein 219 Rnf219 Mus musculus (Mouse) 722 "positive regulation of mRNA splicing, via spliceosome [GO:0048026]" GO:0008270; GO:0048026 0 0 0 0 Q9M8K7 CHOYP_LOC660482.1.1 m.8223 sp DUS1B_ARATH 42.188 128 71 2 1 128 18 142 3.81E-30 109 DUS1B_ARATH reviewed Dual specificity protein phosphatase 1B (AtDsPTP1B) (EC 3.1.3.16) (EC 3.1.3.48) (MAPK phosphatase 2) (AtMKP2) DSPTP1B MKP2 At3g06110 F28L1.5 Arabidopsis thaliana (Mouse-ear cress) 167 cellular response to oxidative stress [GO:0034599]; intracellular signal transduction [GO:0035556]; modulation by symbiont of host defense-related programmed cell death [GO:0034053]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of plant-type hypersensitive response [GO:0034051]; response to oxidative stress [GO:0006979]; response to ozone [GO:0010193] GO:0004725; GO:0005634; GO:0005737; GO:0005886; GO:0006979; GO:0008138; GO:0010193; GO:0033549; GO:0034051; GO:0034053; GO:0034599; GO:0035556; GO:0043407 0 0 0 PF00782; Q9NPA5 CHOYP_BRAFLDRAFT_71707.1.1 m.38862 sp ZF64A_HUMAN 48.193 83 43 0 519 601 173 255 3.81E-20 98.6 ZF64A_HUMAN reviewed "Zinc finger protein 64 homolog, isoforms 1 and 2 (Zfp-64) (Zinc finger protein 338)" ZFP64 ZNF338 Homo sapiens (Human) 681 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF13912; Q9R0Q9 CHOYP_DGRI_GH13077.1.1 m.5229 sp MPU1_MOUSE 49.388 245 124 0 10 254 1 245 3.81E-82 249 MPU1_MOUSE reviewed Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15) Mpdu1 Supl15h Mus musculus (Mouse) 247 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide biosynthetic process [GO:0009312]; transport [GO:0006810] GO:0005739; GO:0005783; GO:0006488; GO:0006810; GO:0009312; GO:0016020; GO:0016021; GO:0070062 0 0 0 PF04193; Q9VCA8 CHOYP_LOC100641396.16.27 m.44607 sp ANKHM_DROME 36.087 230 136 6 4 223 619 847 3.81E-30 121 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; S4R2P9 CHOYP_LOC590169.1.2 m.11271 sp NAC3_MOUSE 33.2 750 396 17 1 666 198 926 3.81E-111 359 NAC3_MOUSE reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Mus musculus (Mouse) 928 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; metal ion transport [GO:0030001]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005887; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0015368; GO:0016528; GO:0021537; GO:0030001; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; A3RLT6 CHOYP_RSSA.7.10 m.47559 sp RSSA_PINFU 84.574 188 29 0 7 194 1 188 3.82E-107 313 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.11.15 m.34405 sp MLRP2_ACRMI 38.547 179 103 3 113 287 874 1049 3.82E-27 114 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E3VWK0 CHOYP_LOC100640001.1.2 m.37241 sp PENH_STREX 28.342 187 101 9 124 293 87 257 3.82E-08 57.4 PENH_STREX reviewed 1-deoxypentalenic acid 11-beta-hydroxylase (EC 1.14.11.35) (Pentalenolactone biosynthesis protein H) penH Streptomyces exfoliatus (Streptomyces hydrogenans) 283 antibiotic biosynthetic process [GO:0017000] GO:0017000; GO:0031418; GO:0046872; GO:0051213 PATHWAY: Antibiotic biosynthesis; pentalenolactone biosynthesis. 0 0 PF05721; G5ED84 CHOYP_BACH1.3.17 m.6935 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 3.82E-11 70.1 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O35548 CHOYP_AAEL_AAEL005666.1.1 m.63610 sp MMP16_RAT 37.458 590 312 19 21 568 15 589 3.82E-109 342 MMP16_RAT reviewed Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) Mmp16 Rattus norvegicus (Rat) 607 collagen catabolic process [GO:0030574] GO:0004222; GO:0005509; GO:0005578; GO:0005886; GO:0008270; GO:0016021; GO:0030574 0 0 cd04278; PF11857;PF00045;PF00413;PF01471; P04792 CHOYP_LOC100211409.1.1 m.4742 sp HSPB1_HUMAN 38.667 75 43 2 161 233 95 168 3.82E-10 60.8 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P04792 CHOYP_RSMB.2.2 m.37626 sp HSPB1_HUMAN 38.667 75 43 2 161 233 95 168 3.82E-10 60.8 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P55088 CHOYP_AQP4.1.3 m.21824 sp AQP4_MOUSE 43.974 307 162 4 17 316 13 316 3.82E-82 254 AQP4_MOUSE reviewed Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) Aqp4 Mus musculus (Mouse) 323 cellular response to interferon-gamma [GO:0071346]; cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; renal water absorption [GO:0070295]; sensory perception of sound [GO:0007605]; water homeostasis [GO:0030104]; water transport [GO:0006833] GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006833; GO:0007605; GO:0009897; GO:0009992; GO:0015250; GO:0015254; GO:0016021; GO:0016323; GO:0030104; GO:0034220; GO:0070295; GO:0071346 0 0 cd00333; PF00230; P86787 CHOYP_GIGA4.2.3 m.41265 sp GIGA4_CRAGI 44.828 58 30 1 40 97 1 56 3.82E-11 60.5 GIGA4_CRAGI reviewed Gigasin-4 (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 58 0 0 0 0 0 0 Q01177 CHOYP_LOC100702671.1.2 m.43837 sp PLMN_RAT 45.455 165 76 5 27 181 102 262 3.82E-35 137 PLMN_RAT reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Rattus norvegicus (Rat) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; proteolysis involved in cellular protein catabolic process [GO:0051603]; tissue regeneration [GO:0042246]; tissue remodeling [GO:0048771]; trophoblast giant cell differentiation [GO:0060707] GO:0004175; GO:0004252; GO:0005576; GO:0005886; GO:0007596; GO:0019897; GO:0042246; GO:0042730; GO:0043231; GO:0045445; GO:0046716; GO:0048771; GO:0051603; GO:0060707; GO:0060716; GO:0071674 0 0 cd00190; PF00051;PF00024;PF00089; Q0E908 CHOYP_SMP_051990.4.7 m.9424 sp HIL_DROME 35.714 448 274 6 18 453 331 776 3.82E-82 291 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q16611 CHOYP_LOC100027503.1.1 m.36317 sp BAK_HUMAN 31.496 127 80 5 36 159 58 180 3.82E-13 68.6 BAK_HUMAN reviewed Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) BAK1 BAK BCL2L7 CDN1 Homo sapiens (Human) 211 activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; activation of signaling protein activity involved in unfolded protein response [GO:0006987]; aging [GO:0007568]; apoptotic process involved in patterning of blood vessels [GO:1902262]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell negative selection [GO:0002352]; blood vessel remodeling [GO:0001974]; brain development [GO:0007420]; cell proliferation [GO:0008283]; cellular response to mechanical stimulus [GO:0071260]; cellular response to UV [GO:0034644]; cytolysis [GO:0019835]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fibroblast apoptotic process [GO:0044346]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; limb morphogenesis [GO:0035108]; mitochondrial fusion [GO:0008053]; myeloid cell homeostasis [GO:0002262]; negative regulation of cell proliferation [GO:0008285]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; organ regeneration [GO:0031100]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; post-embryonic camera-type eye morphogenesis [GO:0048597]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of protein heterodimerization activity [GO:0043497]; regulation of protein homodimerization activity [GO:0043496]; release of cytochrome c from mitochondria [GO:0001836]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to fungus [GO:0009620]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to mycotoxin [GO:0010046]; response to organic cyclic compound [GO:0014070]; response to UV-C [GO:0010225]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068] GO:0001782; GO:0001783; GO:0001836; GO:0001974; GO:0002262; GO:0002352; GO:0005739; GO:0005741; GO:0005783; GO:0005829; GO:0006987; GO:0007420; GO:0007568; GO:0008053; GO:0008283; GO:0008285; GO:0008630; GO:0008635; GO:0009620; GO:0010046; GO:0010225; GO:0010248; GO:0010332; GO:0010524; GO:0010629; GO:0014070; GO:0019835; GO:0031018; GO:0031100; GO:0031307; GO:0032469; GO:0032471; GO:0033137; GO:0034644; GO:0035108; GO:0042493; GO:0042542; GO:0042802; GO:0042803; GO:0043065; GO:0043496; GO:0043497; GO:0044325; GO:0044346; GO:0045471; GO:0045862; GO:0046872; GO:0046902; GO:0046930; GO:0046982; GO:0048597; GO:0051726; GO:0051881; GO:0060068; GO:0070059; GO:0070242; GO:0071260; GO:0090200; GO:0097190; GO:0097192; GO:0097202; GO:1900103; GO:1901030; GO:1902262; GO:1903896 0 0 0 PF00452; Q1HPQ0 CHOYP_TPM2.4.8 m.16036 sp TPM2_BOMMO 72.632 95 24 1 46 138 80 174 3.82E-32 119 TPM2_BOMMO reviewed Tropomyosin-2 0 Bombyx mori (Silk moth) 285 0 0 0 0 0 PF00261; Q2KIJ2 CHOYP_LOC100369432.1.1 m.19523 sp MET18_BOVIN 36.42 162 77 2 1 136 206 367 3.82E-30 114 MET18_BOVIN reviewed Histidine protein methyltransferase 1 homolog (Methyltransferase-like protein 18) (EC 2.1.1.-) METTL18 Bos taurus (Bovine) 373 0 GO:0008168 0 0 0 PF10294; Q3T0K2 CHOYP_LOC100372926.1.3 m.29881 sp TCPG_BOVIN 72.901 262 71 0 1 262 270 531 3.82E-135 426 TCPG_BOVIN reviewed T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) CCT3 Bos taurus (Bovine) 545 binding of sperm to zona pellucida [GO:0007339]; pore complex assembly [GO:0046931]; protein folding [GO:0006457]; toxin transport [GO:1901998] GO:0002199; GO:0005524; GO:0005832; GO:0005874; GO:0005886; GO:0006457; GO:0007339; GO:0043209; GO:0044297; GO:0044822; GO:0046931; GO:0070062; GO:1901998 0 0 cd03337; PF00118; Q4KMJ1 CHOYP_CHAC2.1.1 m.9123 sp CHAC2_DANRE 62.147 177 64 2 1 176 1 175 3.82E-75 226 CHAC2_DANRE reviewed Putative glutathione-specific gamma-glutamylcyclotransferase 2 (Gamma-GCG 2) (EC 2.3.2.-) (Cation transport regulator-like protein 2) chac2 zgc:110055 Danio rerio (Zebrafish) (Brachydanio rerio) 182 0 GO:0016746 0 0 cd06661; PF04752; Q4L235 CHOYP_AASDH.1.1 m.14733 sp ACSF4_HUMAN 47.638 254 123 2 14 267 786 1029 3.82E-69 236 ACSF4_HUMAN reviewed Acyl-CoA synthetase family member 4 (EC 6.2.1.-) (Aminoadipate-semialdehyde dehydrogenase) (Protein NRPS998) AASDH ACSF4 U26 HSPC318 Homo sapiens (Human) 1098 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0006631; GO:0016878 0 0 0 PF00501;PF00550;PF13360;PF13570; Q53G44 CHOYP_LOC101165968.6.7 m.55758 sp IF44L_HUMAN 39.615 260 155 1 20 277 176 435 3.82E-53 182 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q61686 CHOYP_CBX1.4.4 m.44011 sp CBX5_MOUSE 57.714 175 54 3 39 200 20 187 3.82E-62 194 CBX5_MOUSE reviewed Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) Cbx5 Hp1a Mus musculus (Mouse) 191 "negative regulation of transcription, DNA-templated [GO:0045892]" GO:0000118; GO:0000776; GO:0000784; GO:0000792; GO:0003682; GO:0005634; GO:0005720; GO:0005721; GO:0005730; GO:0010369; GO:0016605; GO:0017053; GO:0030674; GO:0035064; GO:0035097; GO:0042803; GO:0042826; GO:0045892; GO:0070491 0 0 0 PF00385;PF01393; Q6GPQ4 CHOYP_BRAFLDRAFT_74594.2.3 m.1285 sp SMYD5_XENLA 22.927 410 237 16 230 598 17 388 3.82E-15 81.6 SMYD5_XENLA reviewed SET and MYND domain-containing protein 5 (EC 2.1.1.-) smyd5 Xenopus laevis (African clawed frog) 421 0 GO:0008168; GO:0046872 0 0 0 PF00856;PF01753; Q6PFY8 CHOYP_LOC100374741.30.83 m.32433 sp TRI45_MOUSE 22.422 223 168 5 39 258 135 355 3.82E-06 53.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R5N8 CHOYP_BRAFLDRAFT_68489.3.3 m.64425 sp TLR13_MOUSE 25.983 966 572 26 7 868 51 977 3.82E-54 207 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q8C522 CHOYP_ENDD1.1.1 m.54535 sp ENDD1_MOUSE 28.716 296 157 13 449 743 36 278 3.82E-15 82.4 ENDD1_MOUSE reviewed Endonuclease domain-containing 1 protein (EC 3.1.30.-) Endod1 Kiaa0830 Mus musculus (Mouse) 501 0 GO:0003676; GO:0004519; GO:0016020; GO:0046872; GO:0070062 0 0 0 0 Q8IN94 CHOYP_OSA.1.2 m.6579 sp OSA_DROME 38.684 760 370 16 1817 2499 1768 2508 3.82E-136 483 OSA_DROME reviewed Trithorax group protein osa (Protein eyelid) osa eld CG7467 Drosophila melanogaster (Fruit fly) 2716 "adult chitin-containing cuticle pigmentation [GO:0048085]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; negative regulation of neuroblast proliferation [GO:0007406]; neuroblast fate commitment [GO:0014017]; neurogenesis [GO:0022008]; photoreceptor cell differentiation [GO:0046530]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; segment specification [GO:0007379]; sensory perception of pain [GO:0019233]; transcription, DNA-templated [GO:0006351]; wing disc dorsal/ventral pattern formation [GO:0048190]; Wnt signaling pathway [GO:0016055]" GO:0003677; GO:0005634; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0006357; GO:0007379; GO:0007406; GO:0007476; GO:0007480; GO:0008586; GO:0008587; GO:0014017; GO:0016055; GO:0016569; GO:0019233; GO:0022008; GO:0035060; GO:0042058; GO:0045893; GO:0046530; GO:0048085; GO:0048190 0 0 0 PF01388;PF12031; Q90W04 CHOYP_LOC100374916.1.1 m.6522 sp NGB_TETNG 25.786 159 114 3 25 182 4 159 3.82E-07 51.2 NGB_TETNG reviewed Neuroglobin ngb GSTENG00032294001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 159 response to hypoxia [GO:0001666] GO:0001666; GO:0005344; GO:0005737; GO:0019825; GO:0020037; GO:0043204; GO:0046872 0 0 0 PF00042; Q9BXJ5 CHOYP_MMRN1.1.2 m.21184 sp C1QT2_HUMAN 31.343 134 79 4 61 186 145 273 3.82E-09 58.2 C1QT2_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 2 C1QTNF2 CTRP2 UNQ6349/PRO21054 Homo sapiens (Human) 285 activation of MAPK activity [GO:0000187]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein heterotrimerization [GO:0070208]; protein homooligomerization [GO:0051260] GO:0000187; GO:0005581; GO:0005615; GO:0045725; GO:0046321; GO:0046326; GO:0051260; GO:0070208 0 0 0 PF00386;PF01391; Q9CZJ2 CHOYP_BRAFLDRAFT_208293.1.20 m.18211 sp HS12B_MOUSE 30.308 650 367 12 29 621 62 682 3.82E-87 288 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9GLY5 CHOYP_ITIH3.3.3 m.55956 sp ITIH3_RABIT 33.406 913 515 19 27 900 45 903 3.82E-152 474 ITIH3_RABIT reviewed Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) ITIH3 Oryctolagus cuniculus (Rabbit) 903 hyaluronan metabolic process [GO:0030212] GO:0004867; GO:0005576; GO:0030212 0 0 0 PF06668;PF08487;PF00092; B0BNE5 CHOYP_RSSA.1.10 m.2055 sp ESTD_RAT 74.502 251 64 0 1 251 30 280 3.83E-147 415 ESTD_RAT reviewed S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) Esd Rattus norvegicus (Rat) 282 formaldehyde catabolic process [GO:0046294] GO:0016023; GO:0018738; GO:0046294; GO:0052689 0 0 0 PF00756; O35165 CHOYP_LOC100367873.1.1 m.57094 sp GOSR2_RAT 54.854 206 92 1 36 241 1 205 3.83E-76 232 GOSR2_RAT reviewed Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin) Gosr2 Gs27 Rattus norvegicus (Rat) 212 "ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein targeting to vacuole [GO:0006623]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion with Golgi apparatus [GO:0048280]" GO:0000139; GO:0000149; GO:0005484; GO:0005789; GO:0005794; GO:0005829; GO:0006623; GO:0006888; GO:0006891; GO:0006896; GO:0012507; GO:0016021; GO:0031201; GO:0031902; GO:0042147; GO:0048280 0 0 0 0 P27465 CHOYP_PISD.2.2 m.30086 sp PISD_CRIGR 50.968 310 138 4 105 409 108 408 3.83E-107 325 PISD_CRIGR reviewed "Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]" Pisd PSSC Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 409 phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540] GO:0004609; GO:0006646; GO:0016540; GO:0031305 0 0 0 PF02666; P33244 CHOYP_FTZ-F1.1.1 m.45653 sp FTZF1_DROME 74.15 147 27 3 36 182 492 627 3.83E-65 224 FTZF1_DROME reviewed Nuclear hormone receptor FTZ-F1 (FTZ-F1 alpha) (Nuclear receptor subfamily 5 group A member 3) ftz-f1 NR5A3 CG4059 Drosophila melanogaster (Fruit fly) 1027 "cell death [GO:0008219]; dendrite morphogenesis [GO:0048813]; imaginal disc-derived leg morphogenesis [GO:0007480]; instar larval or pupal development [GO:0002165]; juvenile hormone mediated signaling pathway [GO:0035626]; lipid homeostasis [GO:0055088]; metamorphosis [GO:0007552]; mushroom body development [GO:0016319]; neuron remodeling [GO:0016322]; olfactory behavior [GO:0042048]; periodic partitioning [GO:0007365]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pupariation [GO:0035073]; pupation [GO:0035074]; regulation of development, heterochronic [GO:0040034]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to ecdysone [GO:0035075]; response to hormone [GO:0009725]" GO:0000976; GO:0001077; GO:0002165; GO:0003677; GO:0003682; GO:0003707; GO:0004879; GO:0005634; GO:0005737; GO:0006355; GO:0006357; GO:0007365; GO:0007480; GO:0007552; GO:0008134; GO:0008219; GO:0008270; GO:0009725; GO:0010906; GO:0016319; GO:0016322; GO:0035073; GO:0035074; GO:0035075; GO:0035626; GO:0040034; GO:0042048; GO:0045944; GO:0046982; GO:0048813; GO:0055088; GO:0090575 0 0 0 PF00104;PF00105; P49013 CHOYP_LOC100888932.1.2 m.28022 sp FBP3_STRPU 54 100 45 1 201 299 166 265 3.83E-29 119 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P50219 CHOYP_LOC100707249.1.1 m.15336 sp MNX1_HUMAN 77.895 95 19 1 172 264 210 304 3.83E-44 159 MNX1_HUMAN reviewed Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9) MNX1 HLXB9 Homo sapiens (Human) 401 "anatomical structure morphogenesis [GO:0009653]; endocrine pancreas development [GO:0031018]; humoral immune response [GO:0006959]; neuron projection morphogenesis [GO:0048812]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spinal cord motor neuron cell fate specification [GO:0021520]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005730; GO:0005737; GO:0006351; GO:0006357; GO:0006959; GO:0009653; GO:0021520; GO:0031018; GO:0043565; GO:0048812 0 0 0 PF00046; P97532 CHOYP_MPST.1.1 m.11853 sp THTM_RAT 48.057 283 144 3 4 285 7 287 3.83E-97 290 THTM_RAT reviewed 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) Mpst Rattus norvegicus (Rat) 297 hydrogen sulfide biosynthetic process [GO:0070814]; kidney development [GO:0001822]; liver development [GO:0001889]; spinal cord development [GO:0021510]; transsulfuration [GO:0019346] GO:0001822; GO:0001889; GO:0004792; GO:0005737; GO:0005739; GO:0005829; GO:0016784; GO:0019346; GO:0021510; GO:0030054; GO:0042802; GO:0043005; GO:0045202; GO:0070062; GO:0070814 0 0 0 PF00581; Q1JPD8 CHOYP_LOC101160876.1.1 m.58883 sp S43A3_BOVIN 27.505 469 295 9 7 458 8 448 3.83E-43 162 S43A3_BOVIN reviewed Solute carrier family 43 member 3 SLC43A3 Bos taurus (Bovine) 489 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 0 PF07690; Q2NKT1 CHOYP_LOC100372995.2.3 m.27493 sp PROF4_BOVIN 47.826 115 59 1 44 157 14 128 3.83E-33 117 PROF4_BOVIN reviewed Profilin-4 PFN4 Bos taurus (Bovine) 129 sequestering of actin monomers [GO:0042989] GO:0003785; GO:0005938; GO:0008289; GO:0015629; GO:0042989 0 0 0 PF00235; Q4FZG9 CHOYP_LOC101243226.1.1 m.21380 sp NUA4L_MOUSE 34.667 75 48 1 38 111 11 85 3.83E-08 50.1 NUA4L_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 Ndufa4l2 Mus musculus (Mouse) 87 hydrogen ion transmembrane transport [GO:1902600] GO:0005751; GO:0008137; GO:1902600 0 0 0 PF06522; Q5D016 CHOYP_LOC100694901.1.3 m.26602 sp PFD1_DANRE 56.842 95 41 0 12 106 1 95 3.83E-29 105 PFD1_DANRE reviewed Prefoldin subunit 1 pfdn1 zgc:110742 Danio rerio (Zebrafish) (Brachydanio rerio) 122 protein folding [GO:0006457] GO:0006457; GO:0016272 0 0 0 PF01920; Q66PY1 CHOYP_EIN_122840.1.1 m.14231 sp SCUB3_MOUSE 29.487 156 103 3 4 158 650 799 3.83E-12 68.2 SCUB3_MOUSE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 3" Scube3 Mus musculus (Mouse) 993 protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260] GO:0005509; GO:0005576; GO:0009986; GO:0051260; GO:0051291 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q67XW5 CHOYP_MYCGRDRAFT_89575.5.12 m.38426 sp UBP18_ARATH 46.774 62 24 2 111 168 52 108 3.83E-06 53.5 UBP18_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (Deubiquitinating enzyme 18) (AtUBP18) (Ubiquitin thioesterase 18) (Ubiquitin-specific-processing protease 18) UBP18 At4g31670 F28M20.140 Arabidopsis thaliana (Mouse-ear cress) 631 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016021; GO:0016579; GO:0036459; GO:0046872 0 0 0 PF00443;PF01753; Q6AYH2 CHOYP_BRAFLDRAFT_114734.5.8 m.18867 sp IN80E_RAT 64.13 92 27 2 14 99 8 99 3.83E-26 104 IN80E_RAT reviewed INO80 complex subunit E (Coiled-coil domain-containing protein 95) Ino80e Ccdc95 Rattus norvegicus (Rat) 244 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006260; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0031011 0 0 0 0 Q6AYH2 CHOYP_LOC100186361.1.3 m.17828 sp IN80E_RAT 64.13 92 27 2 14 99 8 99 3.83E-26 104 IN80E_RAT reviewed INO80 complex subunit E (Coiled-coil domain-containing protein 95) Ino80e Ccdc95 Rattus norvegicus (Rat) 244 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006260; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0031011 0 0 0 0 Q6DHK1 CHOYP_OTU5B.1.1 m.6212 sp NNRE_DANRE 60.377 265 104 1 4 268 20 283 3.83E-115 335 NNRE_DANRE reviewed NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) naxe aibp apoa1bp si:dkeyp-84f11.6 zgc:92263 Danio rerio (Zebrafish) (Brachydanio rerio) 283 0 GO:0000166; GO:0005576; GO:0005739; GO:0046872; GO:0052856; GO:0052857 0 0 0 PF03853; Q6GQR8 CHOYP_ZFP37.1.4 m.10878 sp ZN329_MOUSE 39.228 311 166 3 180 471 179 485 3.83E-63 218 ZN329_MOUSE reviewed Zinc finger protein 329 Znf329 Zfp329 Mus musculus (Mouse) 522 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q6IV78 CHOYP_TAZ.1.1 m.8371 sp TAZ_SAISC 44.706 255 135 3 6 259 7 256 3.83E-77 238 TAZ_SAISC reviewed Tafazzin TAZ Saimiri sciureus (Common squirrel monkey) 262 phospholipid metabolic process [GO:0006644] GO:0006644; GO:0016021; GO:0016746 0 0 0 PF01553; Q6P9T8 CHOYP_TBB.6.7 m.64497 sp TBB4B_RAT 96.5 200 7 0 1 200 1 200 3.83E-143 409 TBB4B_RAT reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Rattus norvegicus (Rat) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q7N571 CHOYP_LOC659092.1.1 m.49049 sp GHRA_PHOLL 32.549 255 158 6 76 323 66 313 3.83E-32 124 GHRA_PHOLL reviewed Glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) (EC 1.1.1.81) (2-ketoacid reductase) ghrA plu2086 Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 313 0 GO:0005737; GO:0005886; GO:0016618; GO:0030267; GO:0051287 0 0 0 PF02826; Q8BUL6 CHOYP_PLEKHA1.1.2 m.18534 sp PKHA1_MOUSE 60.377 53 21 0 51 103 192 244 3.83E-14 70.1 PKHA1_MOUSE reviewed Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1) Plekha1 Tapp1 Mus musculus (Mouse) 383 androgen metabolic process [GO:0008209]; B cell receptor signaling pathway [GO:0050853]; cellular response to hydrogen peroxide [GO:0070301]; establishment of protein localization [GO:0045184]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; multicellular organism growth [GO:0035264]; negative regulation of protein kinase B signaling [GO:0051898]; palate development [GO:0060021]; phosphatidylinositol 3-kinase signaling [GO:0014065]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; ruffle organization [GO:0031529]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283] GO:0001553; GO:0005654; GO:0005737; GO:0005886; GO:0007283; GO:0008209; GO:0008210; GO:0008585; GO:0009791; GO:0014065; GO:0016020; GO:0030165; GO:0031529; GO:0032587; GO:0033327; GO:0035091; GO:0035264; GO:0043325; GO:0045184; GO:0048008; GO:0048705; GO:0050853; GO:0051898; GO:0060021; GO:0060325; GO:0070062; GO:0070301 0 0 0 PF00169; Q8C525 CHOYP_LOC100377009.6.10 m.51942 sp M21D2_MOUSE 28.834 163 99 6 132 293 176 322 3.83E-08 59.7 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8CGE9 CHOYP_LOC100692579.1.1 m.12248 sp RGS12_MOUSE 36.277 419 219 10 72 467 708 1101 3.83E-73 256 RGS12_MOUSE reviewed Regulator of G-protein signaling 12 (RGS12) Rgs12 Mus musculus (Mouse) 1381 termination of G-protein coupled receptor signaling pathway [GO:0038032] GO:0005057; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0030054; GO:0030425; GO:0030695; GO:0038032; GO:0043025; GO:0043234; GO:0045202; GO:0097440 0 0 0 PF02188;PF00595;PF02196;PF00615; Q9BYK8 CHOYP_LOC586432.2.2 m.57105 sp HELZ2_HUMAN 24.497 547 334 19 40 562 1513 2004 3.83E-27 121 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9ESN6 CHOYP_LOC100374741.42.83 m.39004 sp TRIM2_MOUSE 28.649 185 102 8 345 516 535 702 3.83E-07 56.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A1L1W9 CHOYP_MOT10.1.1 m.38677 sp MOT10_DANRE 45.74 446 222 6 25 463 48 480 3.84E-128 387 MOT10_DANRE reviewed Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10) slc16a10 si:ch211-241j12.1 zgc:158478 Danio rerio (Zebrafish) (Brachydanio rerio) 505 ion transmembrane transport [GO:0034220] GO:0005215; GO:0005887; GO:0015173; GO:0015349; GO:0016021; GO:0034220 0 0 cd06174; PF07690; A4IF63 CHOYP_TRIM3.16.58 m.25078 sp TRIM2_BOVIN 26.217 267 144 8 193 407 468 733 3.84E-16 84 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E7F6F9 CHOYP_LOC100197217.2.2 m.22709 sp KLHL3_DANRE 27.723 101 66 2 27 123 60 157 3.84E-06 53.5 KLHL3_DANRE reviewed Kelch-like protein 3 klhl3 Danio rerio (Zebrafish) (Brachydanio rerio) 601 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O01761 CHOYP_UNC-89.1.2 m.1626 sp UNC89_CAEEL 26.139 505 331 15 6 482 5291 5781 3.84E-31 137 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; P05388 CHOYP_BRAFLDRAFT_127105.1.1 m.21925 sp RLA0_HUMAN 66.667 99 33 0 1 99 177 275 3.84E-46 153 RLA0_HUMAN reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Homo sapiens (Human) 317 "cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0002181; GO:0003735; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0030529; GO:0030687; GO:0036464; GO:0044822; GO:0070062; GO:0070180 0 0 0 PF00466; P35992 CHOYP_PTPRQ.2.8 m.13345 sp PTP10_DROME 36.236 781 429 19 431 1196 832 1558 3.84E-124 426 PTP10_DROME reviewed Tyrosine-protein phosphatase 10D (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 10D) (DPTP10D) Ptp10D CG1817 Drosophila melanogaster (Fruit fly) 1990 axon guidance [GO:0007411]; central nervous system development [GO:0007417]; long-term memory [GO:0007616]; motor neuron axon guidance [GO:0008045]; open tracheal system development [GO:0007424]; protein dephosphorylation [GO:0006470] GO:0004721; GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007411; GO:0007417; GO:0007424; GO:0007616; GO:0008045; GO:0016021; GO:0030424; GO:0045177 0 0 0 PF00041;PF00102; P86856 CHOYP_MANL.7.9 m.43705 sp MANL_MYTCA 40.897 379 157 8 68 440 2 319 3.84E-80 253 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q02953 CHOYP_HSF.1.1 m.47858 sp HSF_SCHPO 28.682 129 78 6 18 137 52 175 3.84E-07 54.7 HSF_SCHPO reviewed Heat shock factor protein (HSF) (Heat shock transcription factor) (HSTF) hsf1 hsf SPAC2E12.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 609 "positive regulation of cellular response to heat [GO:1900036]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000790; GO:0000978; GO:0000982; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0045944; GO:1900036 0 0 0 PF00447; Q06852 CHOYP_LOC100497129.5.8 m.38522 sp SLAP1_CLOTH 56.928 664 191 54 1787 2385 1382 2015 3.84E-63 244 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q14146 CHOYP_URB2.2.2 m.12595 sp URB2_HUMAN 28.763 299 197 7 295 582 1219 1512 3.84E-25 114 URB2_HUMAN reviewed Unhealthy ribosome biogenesis protein 2 homolog URB2 KIAA0133 Homo sapiens (Human) 1524 0 GO:0005730; GO:0016235 0 0 0 PF10441; Q3TWI9 CHOYP_contig_009370 m.10898 sp CSCL2_MOUSE 43.297 552 299 7 1 544 224 769 3.84E-152 461 CSCL2_MOUSE reviewed CSC1-like protein 2 (Transmembrane protein 63B) Tmem63b Mus musculus (Mouse) 832 ion transport [GO:0006811] GO:0000166; GO:0005886; GO:0006811; GO:0015629; GO:0016021 0 0 0 PF14703;PF02714;PF13967; Q5RE08 CHOYP_FBX22.1.1 m.35385 sp FBX22_PONAB 28.431 408 245 15 30 418 22 401 3.84E-38 145 FBX22_PONAB reviewed F-box only protein 22 FBXO22 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 403 0 GO:0030018 0 0 0 PF00646;PF10442; Q5RFV8 CHOYP_CB044.1.1 m.53539 sp WDCP_DANRE 28.059 474 270 19 1 432 1 445 3.84E-39 159 WDCP_DANRE reviewed WD repeat and coiled-coil-containing protein wdcp si:dkeyp-115a10.2 zgc:103511 Danio rerio (Zebrafish) (Brachydanio rerio) 714 0 0 0 0 0 PF15390; Q6UX65 CHOYP_BRAFLDRAFT_125861.1.1 m.66472 sp DRAM2_HUMAN 43.462 260 140 4 35 290 6 262 3.84E-62 200 DRAM2_HUMAN reviewed DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) DRAM2 TMEM77 PSEC0031 UNQ154/PRO180 Homo sapiens (Human) 266 apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601] GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006914; GO:0006915; GO:0007601; GO:0010506; GO:0016021; GO:0016324; GO:0043231; GO:0045494 0 0 0 PF10277; Q7TSH8 CHOYP_LOC585822.1.1 m.17065 sp TMM94_MOUSE 35.409 257 158 3 41 290 989 1244 3.84E-43 160 TMM94_MOUSE reviewed Transmembrane protein 94 Tmem94 Kiaa0195 Mus musculus (Mouse) 1360 0 GO:0005654; GO:0016021 0 0 0 0 Q80TE7 CHOYP_BRAFLDRAFT_206003.1.2 m.16465 sp LRRC7_MOUSE 52.749 491 218 5 1 484 7 490 3.84E-168 543 LRRC7_MOUSE reviewed Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1) Lrrc7 Kiaa1365 Lap1 Mus musculus (Mouse) 1490 0 GO:0005737; GO:0014069; GO:0030054; GO:0045211 0 0 0 PF13855;PF00595; Q810C0 CHOYP_BRAFLDRAFT_185990.1.1 m.24877 sp SLIK2_MOUSE 32.461 191 123 4 117 305 39 225 3.84E-13 76.3 SLIK2_MOUSE reviewed SLIT and NTRK-like protein 2 Slitrk2 Mus musculus (Mouse) 846 axonogenesis [GO:0007409]; positive regulation of synapse assembly [GO:0051965] GO:0007409; GO:0016021; GO:0051965 0 0 0 PF13855; Q8C761 CHOYP_LOC100373809.1.2 m.35126 sp WDR60_MOUSE 33.173 1040 601 26 1 1004 1 982 3.84E-146 464 WDR60_MOUSE reviewed WD repeat-containing protein 60 Wdr60 Mus musculus (Mouse) 999 cell projection organization [GO:0030030] GO:0005615; GO:0005929; GO:0030030; GO:0070062 0 0 0 PF00400; Q8K3A0 CHOYP_LOC100177909.1.1 m.29356 sp HSC20_MOUSE 38.298 188 112 3 79 262 40 227 3.84E-36 131 HSC20_MOUSE reviewed "Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (Hsc20)" Hscb Hsc20 Mus musculus (Mouse) 234 iron-sulfur cluster assembly [GO:0016226]; protein folding [GO:0006457]; protein oligomerization [GO:0051259] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0016226; GO:0046872; GO:0051087; GO:0051259 PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. 0 cd06257; PF07743; Q8N157 CHOYP_LOC100892609.1.1 m.50637 sp AHI1_HUMAN 41.905 105 39 3 30 113 1006 1109 3.84E-17 82 AHI1_HUMAN reviewed Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1) AHI1 Homo sapiens (Human) 1196 cellular protein localization [GO:0034613]; central nervous system development [GO:0007417]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; cloaca development [GO:0035844]; heart looping [GO:0001947]; hindbrain development [GO:0030902]; Kupffer's vesicle development [GO:0070121]; left/right axis specification [GO:0070986]; morphogenesis of a polarized epithelium [GO:0001738]; negative regulation of apoptotic process [GO:0043066]; otic vesicle development [GO:0071599]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of polarized epithelial cell differentiation [GO:0030862]; positive regulation of receptor internalization [GO:0002092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pronephric duct morphogenesis [GO:0039023]; pronephric nephron tubule morphogenesis [GO:0039008]; regulation of behavior [GO:0050795]; retina layer formation [GO:0010842]; specification of axis polarity [GO:0065001]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vesicle-mediated transport [GO:0016192] GO:0001738; GO:0001947; GO:0002092; GO:0005813; GO:0005814; GO:0005829; GO:0005911; GO:0005912; GO:0005929; GO:0007169; GO:0007417; GO:0010842; GO:0016192; GO:0030862; GO:0030902; GO:0031513; GO:0034613; GO:0035844; GO:0035845; GO:0036038; GO:0036064; GO:0039008; GO:0039023; GO:0042384; GO:0042802; GO:0043066; GO:0045944; GO:0050795; GO:0060271; GO:0065001; GO:0070121; GO:0070986; GO:0071599; GO:0072372 0 0 0 PF00018;PF00400; Q8WZ42 CHOYP_TITIN.1.19 m.2116 sp TITIN_HUMAN 34.783 92 60 0 1859 1950 104 195 3.84E-09 66.2 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q92113 CHOYP_LOC100371043.3.5 m.24649 sp CP17A_SQUAC 37.5 296 173 4 3 292 187 476 3.84E-66 219 CP17A_SQUAC reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) 509 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q92851 CHOYP_LOC795066.1.3 m.34060 sp CASPA_HUMAN 35.036 137 72 5 14 147 280 402 3.84E-14 78.6 CASPA_HUMAN reviewed Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005829; GO:0006915; GO:0007166; GO:0008625; GO:0030225; GO:0031265; GO:0031625; GO:0035877; GO:0042981; GO:0043123; GO:0097190; GO:0097199; GO:0097342 0 0 0 PF01335; Q96MM6 CHOYP_LOC100207121.4.9 m.39910 sp HS12B_HUMAN 26.825 630 372 17 16 560 61 686 3.84E-61 217 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9D2L9 CHOYP_LOC100768019.2.3 m.55436 sp F111A_MOUSE 25 292 189 11 769 1048 325 598 3.84E-07 57.8 F111A_MOUSE reviewed Protein FAM111A Fam111a Kiaa1895 Mus musculus (Mouse) 613 DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071] GO:0000785; GO:0005634; GO:0005737; GO:0006260; GO:0045071 0 0 0 0 Q9JJ61 CHOYP_LOC100700826.1.1 m.17276 sp GLT16_MOUSE 32.566 565 344 18 1 539 1 554 3.84E-87 283 GLT16_MOUSE reviewed Polypeptide N-acetylgalactosaminyltransferase 16 (EC 2.4.1.41) (Polypeptide GalNAc transferase 16) (GalNAc-T16) (Polypeptide GalNAc transferase-like protein 1) (GalNAc-T-like protein 1) (pp-GaNTase-like protein 1) (Polypeptide N-acetylgalactosaminyltransferase-like protein 1) (Protein-UDP acetylgalactosaminyltransferase-like protein 1) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1) Galnt16 Galntl1 Mus musculus (Mouse) 558 protein glycosylation [GO:0006486] GO:0000139; GO:0004653; GO:0006486; GO:0016021; GO:0030246; GO:0046872; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q9VVN2 CHOYP_AGAP_AGAP004481.1.1 m.8676 sp RT26_DROME 29.688 192 99 5 26 197 25 200 3.84E-10 60.8 RT26_DROME reviewed "Probable 28S ribosomal protein S26, mitochondrial (MRP-S26) (S26mt)" mRpS26 CG7354 Drosophila melanogaster (Fruit fly) 225 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005763; GO:0006412 0 0 0 PF14943; Q9Y5X3 CHOYP_BRAFLDRAFT_121151.1.1 m.59381 sp SNX5_HUMAN 27.851 377 247 10 49 403 29 402 3.84E-34 134 SNX5_HUMAN reviewed Sorting nexin-5 SNX5 Homo sapiens (Human) 404 "intracellular protein transport [GO:0006886]; pinocytosis [GO:0006907]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle organization [GO:0016050]" GO:0001726; GO:0001891; GO:0005829; GO:0005913; GO:0006886; GO:0006907; GO:0016050; GO:0016241; GO:0030659; GO:0030904; GO:0030905; GO:0031234; GO:0031313; GO:0031901; GO:0034452; GO:0035091; GO:0042147; GO:0046982; GO:0070685; GO:0097422; GO:0098641 0 0 0 PF00787;PF09325; E1BD59 CHOYP_TRIM2.25.59 m.34279 sp TRI56_BOVIN 47.297 74 36 1 7 80 17 87 3.85E-15 76.3 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; P27867 CHOYP_DHSO.1.2 m.5409 sp DHSO_RAT 55.62 347 152 1 4 350 9 353 3.85E-144 414 DHSO_RAT reviewed Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) Sord Sdh1 Rattus norvegicus (Rat) 357 fructose biosynthetic process [GO:0046370]; L-xylitol catabolic process [GO:0051160]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to hormone [GO:0009725]; response to nutrient levels [GO:0031667]; response to osmotic stress [GO:0006970]; sorbitol catabolic process [GO:0006062]; sperm motility [GO:0030317] GO:0003939; GO:0006062; GO:0006970; GO:0008270; GO:0009725; GO:0030317; GO:0031514; GO:0031667; GO:0031966; GO:0042493; GO:0042802; GO:0046370; GO:0046526; GO:0046686; GO:0046688; GO:0051160; GO:0051287; GO:0070062 0 0 0 PF08240;PF00107; P28799 CHOYP_BRAFLDRAFT_102424.6.6 m.64911 sp GRN_HUMAN 38.676 574 296 15 176 731 46 581 3.85E-113 362 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P29147 CHOYP_LOC100702424.1.1 m.28522 sp BDH_RAT 40.138 289 161 6 65 343 56 342 3.85E-65 214 BDH_RAT reviewed "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH)" Bdh1 Bdh Rattus norvegicus (Rat) 343 adipose tissue development [GO:0060612]; brain development [GO:0007420]; liver development [GO:0001889]; response to cadmium ion [GO:0046686]; response to corticosterone [GO:0051412]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to growth hormone [GO:0060416]; response to hormone [GO:0009725]; response to insulin [GO:0032868]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to toxic substance [GO:0009636] GO:0001889; GO:0003858; GO:0005543; GO:0005743; GO:0005759; GO:0007420; GO:0007584; GO:0009636; GO:0009725; GO:0032355; GO:0032868; GO:0042493; GO:0042594; GO:0045471; GO:0046686; GO:0051412; GO:0060416; GO:0060612; GO:0099617 0 0 0 PF00106; P42674 CHOYP_LOC593467.4.4 m.66958 sp BP10_PARLI 36.943 314 169 11 1 306 153 445 3.85E-48 179 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P49256 CHOYP_ISCW_ISCW012623.1.1 m.26452 sp LMAN2_CANLF 54.723 307 133 5 43 345 52 356 3.85E-114 338 LMAN2_CANLF reviewed Vesicular integral-membrane protein VIP36 (Lectin mannose-binding 2) (Vesicular integral-membrane protein 36) (VIP36) LMAN2 Canis lupus familiaris (Dog) (Canis familiaris) 356 protein transport [GO:0015031] GO:0000139; GO:0005794; GO:0015031; GO:0016021; GO:0030137; GO:0030246; GO:0031410; GO:0046872; GO:0048471 0 0 0 PF03388; P53563 CHOYP_B2CL1.1.1 m.14065 sp B2CL1_RAT 32.11 109 69 3 629 733 86 193 3.85E-07 55.1 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; P55043 CHOYP_LOC100645082.1.1 m.14803 sp RAD_RAT 39.063 128 73 2 27 149 129 256 3.85E-21 91.3 RAD_RAT reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) Rrad Rad Rattus norvegicus (Rat) 306 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; P76536 CHOYP_LOC100371249.1.1 m.63117 sp YFEX_ECOLI 32.302 291 178 9 87 369 17 296 3.85E-36 136 YFEX_ECOLI reviewed Probable deferrochelatase/peroxidase YfeX (EC 1.11.1.-) yfeX b2431 JW2424 Escherichia coli (strain K12) 299 0 GO:0004601; GO:0005737; GO:0005829; GO:0020037; GO:0046872 0 0 0 PF04261; Q17938 CHOYP_LOC100216141.1.1 m.32125 sp DAF36_CAEEL 41.176 425 219 11 42 454 7 412 3.85E-108 330 DAF36_CAEEL reviewed Cholesterol 7-desaturase (EC 1.14.19.21) (Cholesterol desaturase daf-36) daf-36 C12D8.5 Caenorhabditis elegans 428 cholesterol metabolic process [GO:0008203] GO:0005737; GO:0008203; GO:0016021; GO:0016491; GO:0046872; GO:0051537 "PATHWAY: Steroid hormone biosynthesis; dafachronic acid biosynthesis. {ECO:0000269|PubMed:21632547, ECO:0000269|PubMed:21749634}." 0 0 PF00355; Q2M385 CHOYP_LOC100721584.1.1 m.52602 sp MPEG1_HUMAN 40.816 588 325 12 34 606 42 621 3.85E-151 457 MPEG1_HUMAN reviewed Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Homo sapiens (Human) 716 0 GO:0016021 0 0 0 PF01823; Q5RET6 CHOYP_T184C.2.2 m.36661 sp T184C_PONAB 50.794 189 71 4 1 186 225 394 3.85E-54 184 T184C_PONAB reviewed Transmembrane protein 184C (Transmembrane protein 34) TMEM184C TMEM34 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 438 0 GO:0016021 0 0 0 PF03619; Q5ZJL9 CHOYP_SAMH1.6.12 m.32342 sp SAMH1_CHICK 49.691 485 202 8 75 547 107 561 3.85E-152 452 SAMH1_CHICK reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) 614 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966; Q642M9 CHOYP_LOC100880339.1.1 m.57568 sp DHDH_DANRE 39.45 327 198 0 1 327 1 327 3.85E-78 245 DHDH_DANRE reviewed "Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) (D-xylose 1-dehydrogenase) (D-xylose-NADP dehydrogenase) (EC 1.1.1.179) (Dimeric dihydrodiol dehydrogenase)" dhdh ch211-203b17.3 zgc:101723 Danio rerio (Zebrafish) (Brachydanio rerio) 334 D-xylose catabolic process [GO:0042843] GO:0042843; GO:0047115; GO:0047837 0 0 0 PF01408; Q6DGN0 CHOYP_ISCW_ISCW014390.1.1 m.57615 sp RERGL_DANRE 41.379 116 61 2 32 142 72 185 3.85E-22 91.7 RERGL_DANRE reviewed Ras-related and estrogen-regulated growth inhibitor-like protein (RERG/Ras-like protein) rergl zgc:92849 Danio rerio (Zebrafish) (Brachydanio rerio) 205 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0016020 0 0 0 PF00071; Q6QLW4 CHOYP_CYC.4.5 m.57589 sp CYC_PECGU 84.404 109 17 0 27 135 1 109 3.85E-65 196 CYC_PECGU reviewed Cytochrome c 0 Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm) 109 oxidation-reduction process [GO:0055114] GO:0005758; GO:0009055; GO:0020037; GO:0046872; GO:0055114; GO:0070469 0 0 0 PF00034; Q6R7E2 CHOYP_BIR1G.1.2 m.26048 sp IAP2_OSHVF 35.149 202 93 7 38 234 2 170 3.85E-28 107 IAP2_OSHVF reviewed Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 170 0 0 0 0 0 PF00653; Q80UY1 CHOYP_LOC100561810.1.1 m.8656 sp CARME_MOUSE 53.352 358 161 3 11 366 47 400 3.85E-140 407 CARME_MOUSE reviewed Carnosine N-methyltransferase (EC 2.1.1.22) Carnmt1 Mus musculus (Mouse) 400 carnosine metabolic process [GO:0035498] GO:0005634; GO:0005829; GO:0030735; GO:0035498 0 0 0 PF07942; Q8BP74 CHOYP_LOC100699733.1.1 m.6592 sp PSTK_MOUSE 31.21 314 175 10 15 301 52 351 3.85E-40 146 PSTK_MOUSE reviewed L-seryl-tRNA(Sec) kinase (EC 2.7.1.164) (O-phosphoseryl-tRNA(Sec) kinase) Pstk Mus musculus (Mouse) 359 selenocysteine incorporation [GO:0001514]; selenocysteine metabolic process [GO:0016259]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056] GO:0000049; GO:0001514; GO:0005524; GO:0005739; GO:0005829; GO:0016259; GO:0016301; GO:0097056; GO:0098620 PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 1/2. 0 0 PF08433; Q8IZT8 CHOYP_LOC101165781.1.1 m.7279 sp HS3S5_HUMAN 55.814 258 114 0 69 326 88 345 3.85E-106 317 HS3S5_HUMAN reviewed Heparan sulfate glucosamine 3-O-sulfotransferase 5 (EC 2.8.2.23) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5) (3-OST-5) (Heparan sulfate 3-O-sulfotransferase 5) (h3-OST-5) HS3ST5 3OST5 HS3OST5 Homo sapiens (Human) 346 "glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process, enzymatic modification [GO:0015015]; negative regulation of coagulation [GO:0050819]; protein sulfation [GO:0006477]; regulation of viral entry into host cell [GO:0046596]" GO:0000139; GO:0006024; GO:0006477; GO:0008467; GO:0015015; GO:0016021; GO:0046596; GO:0050656; GO:0050819 0 0 0 PF00685; Q8NDZ4 CHOYP_DIA1.1.1 m.57066 sp DIA1_HUMAN 40.602 399 220 6 56 442 34 427 3.85E-100 309 DIA1_HUMAN reviewed Deleted in autism protein 1 (Golgi Protein of 49 kDa) (GoPro49) (Hypoxia and AKT-induced stem cell factor) (HASF) C3orf58 DIA1 Homo sapiens (Human) 430 cardiac muscle cell proliferation [GO:0060038]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066] GO:0000139; GO:0005615; GO:0014066; GO:0030126; GO:0060038 0 0 0 PF12260; Q96GP6 CHOYP_MEG10.37.91 m.39822 sp SREC2_HUMAN 40.816 98 55 3 191 287 271 366 3.85E-11 67 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q96RW7 CHOYP_BRAFLDRAFT_88566.5.11 m.27248 sp HMCN1_HUMAN 42.398 342 172 13 26 345 4532 4870 3.85E-65 236 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96RW7 CHOYP_NEMVEDRAFT_V1G88031.4.5 m.51405 sp HMCN1_HUMAN 40.517 116 50 7 80 191 4528 4628 3.85E-17 83.2 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99M80 CHOYP_PTPRE.9.19 m.41700 sp PTPRT_MOUSE 29.715 737 473 13 385 1090 731 1453 3.85E-84 303 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BYK8 CHOYP_LOC583716.4.4 m.54140 sp HELZ2_HUMAN 30.167 1200 692 39 54 1189 1507 2624 3.85E-147 495 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9EPH8 CHOYP_LOC101236942.1.1 m.54822 sp PABP1_RAT 85.227 88 13 0 19 106 536 623 3.85E-42 149 PABP1_RAT reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) Pabpc1 Pabp1 Rattus norvegicus (Rat) 636 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0003729; GO:0005681; GO:0006397; GO:0008143; GO:0008380; GO:0010494; GO:0030425; GO:0030529; GO:0031047; GO:0060213; GO:1900153; GO:1990124; GO:2000623 0 0 0 PF00658;PF00076; Q9GZ71 CHOYP_TBA.2.6 m.22414 sp TPM_HALDV 98.333 120 2 0 4 123 165 284 3.85E-74 224 TPM_HALDV reviewed Tropomyosin 0 Haliotis diversicolor (Abalone) (Sulculus diversicolor) 284 0 0 0 0 0 PF00261; Q9VCA8 CHOYP_LOC754728.5.6 m.42236 sp ANKHM_DROME 31.175 417 235 14 797 1202 550 925 3.85E-32 140 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9WVL2 CHOYP_MC28_D181.1.1 m.45045 sp STAT2_MOUSE 43.564 101 55 1 118 216 761 861 3.85E-06 50.4 STAT2_MOUSE reviewed Signal transducer and activator of transcription 2 Stat2 Mus musculus (Mouse) 923 "defense response to virus [GO:0051607]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; transcription, DNA-templated [GO:0006351]; type I interferon signaling pathway [GO:0060337]; xenophagy [GO:0098792]" GO:0001932; GO:0002230; GO:0003677; GO:0003700; GO:0004871; GO:0005634; GO:0005737; GO:0005886; GO:0006351; GO:0042802; GO:0051607; GO:0060337; GO:0090140; GO:0098779; GO:0098792 0 0 0 PF00017;PF12188;PF01017;PF02864;PF02865; Q9Y3Z3 CHOYP_SAMH1.11.12 m.61563 sp SAMH1_HUMAN 37.759 482 226 12 18 461 110 555 3.85E-93 299 SAMH1_HUMAN reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) SAMHD1 MOP5 Homo sapiens (Human) 626 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; immune response [GO:0006955]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; type I interferon signaling pathway [GO:0060337] GO:0003676; GO:0003723; GO:0005622; GO:0005634; GO:0005654; GO:0005886; GO:0006203; GO:0006955; GO:0008270; GO:0008832; GO:0032567; GO:0045088; GO:0046061; GO:0051289; GO:0051607; GO:0060337 0 0 0 PF01966;PF07647; A1ZA47 CHOYP_SMP_006860.2.2.4 m.24582 sp ZASP_DROME 36.471 85 53 1 58 141 4 88 3.86E-10 62 ZASP_DROME reviewed PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) 2194 muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952] GO:0001725; GO:0001952; GO:0003779; GO:0005915; GO:0005925; GO:0005927; GO:0008270; GO:0015629; GO:0016323; GO:0030018; GO:0030239; GO:0031252; GO:0045177; GO:0045178; GO:0051371; GO:0061061 0 0 0 PF15936;PF00412;PF00595; A2AAJ9 CHOYP_LOC100367089.2.4 m.1914 sp OBSCN_MOUSE 32.8 125 79 2 17 138 89 211 3.86E-13 76.3 OBSCN_MOUSE reviewed Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Obscn Gm878 Mus musculus (Mouse) 8891 cell differentiation [GO:0030154]; mitophagy in response to mitochondrial depolarization [GO:0098779]; multicellular organism development [GO:0007275]; regulation of Rho protein signal transduction [GO:0035023] GO:0004674; GO:0005089; GO:0005524; GO:0005863; GO:0007275; GO:0030018; GO:0030154; GO:0030506; GO:0031430; GO:0031432; GO:0035023; GO:0098779 0 0 0 PF00041;PF07679;PF00612;PF00069;PF00621; B0V2N1 CHOYP_LOC100208822.2.2 m.47414 sp PTPRS_MOUSE 29.832 476 321 8 506 974 1258 1727 3.86E-57 219 PTPRS_MOUSE reviewed Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (PTPNU-3) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) Ptprs Mus musculus (Mouse) 1907 cell adhesion [GO:0007155]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; corpus callosum development [GO:0022038]; establishment of endothelial intestinal barrier [GO:0090557]; hippocampus development [GO:0021766]; peptidyl-tyrosine dephosphorylation [GO:0035335]; spinal cord development [GO:0021510] GO:0004725; GO:0007155; GO:0016021; GO:0021510; GO:0021549; GO:0021766; GO:0021987; GO:0022038; GO:0035335; GO:0070062; GO:0090557 0 0 0 PF00041;PF07679;PF00102; O08623 CHOYP_KTNA1.2.2 m.63437 sp SQSTM_RAT 34.034 476 218 17 2 428 3 431 3.86E-64 216 SQSTM_RAT reviewed Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62) Sqstm1 Zip Rattus norvegicus (Rat) 439 apoptotic process [GO:0006915]; autophagy [GO:0006914]; cell differentiation [GO:0030154]; immune system process [GO:0002376]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein phosphorylation [GO:0001934]; protein heterooligomerization [GO:0051291]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of protein complex stability [GO:0061635]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000407; GO:0000932; GO:0001934; GO:0002376; GO:0005080; GO:0005770; GO:0005776; GO:0005783; GO:0006511; GO:0006914; GO:0006915; GO:0008270; GO:0016235; GO:0016236; GO:0016239; GO:0016605; GO:0030154; GO:0031410; GO:0042169; GO:0042803; GO:0043122; GO:0043130; GO:0044130; GO:0044753; GO:0044754; GO:0051291; GO:0061635; GO:0070062; GO:0097225; GO:0098779 0 0 0 PF00564;PF00569; O14522 CHOYP_MEGF6.9.59 m.21609 sp PTPRT_HUMAN 27.626 438 300 6 12 435 1006 1440 3.86E-45 172 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O62640 CHOYP_BIRC2.1.13 m.4344 sp PIAP_PIG 34.737 285 173 6 233 516 86 358 3.86E-51 181 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P48725 CHOYP_LOC100368547.39.40 m.59645 sp PCNT_MOUSE 33.083 133 80 5 1 129 2739 2866 3.86E-07 51.6 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; Q03601 CHOYP_BRAFLDRAFT_75840.1.1 m.37071 sp NHL1_CAEEL 32.54 126 66 5 11 119 42 165 3.86E-14 71.6 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q04832 CHOYP_MTR_5G086730.1.1 m.30435 sp HEXP_LEIMA 34.579 107 51 4 17 110 55 155 3.86E-12 65.1 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q28983 CHOYP_APRE_1119.1.1 m.33657 sp ZAN_PIG 30.738 244 118 9 211 419 297 524 3.86E-08 62 ZAN_PIG reviewed Zonadhesin ZAN Sus scrofa (Pig) 2476 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840 0 0 cd06263; PF08742;PF00008;PF00629;PF01826;PF12714;PF00094; Q5EA45 CHOYP_CPIPJ_CPIJ004840.1.1 m.3309 sp FXRD1_BOVIN 48.364 428 210 7 87 505 61 486 3.86E-131 392 FXRD1_BOVIN reviewed FAD-dependent oxidoreductase domain-containing protein 1 (EC 1.-.-.-) FOXRED1 Bos taurus (Bovine) 486 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005743; GO:0005747; GO:0016021; GO:0016491; GO:0032981 0 0 0 PF01266; Q5ND28 CHOYP_CED1.19.29 m.44978 sp SREC_MOUSE 29.514 288 159 12 82 344 212 480 3.86E-21 98.2 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RBU8 CHOYP_LOC100748395.2.7 m.14770 sp ROA2_PONAB 53.684 190 88 0 37 226 16 205 3.86E-66 217 ROA2_PONAB reviewed Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 353 "miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; primary miRNA processing [GO:0031053]" GO:0000166; GO:0000398; GO:0003730; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006406; GO:0030529; GO:0031053; GO:0035198; GO:0043047; GO:0070062; GO:1990247; GO:1990428 0 0 0 PF00076; Q5TCZ1 CHOYP_LOC100208234.1.1 m.39495 sp SPD2A_HUMAN 29.358 109 71 2 30 132 22 130 3.86E-08 55.1 SPD2A_HUMAN reviewed SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) SH3PXD2A FISH KIAA0418 SH3MD1 TKS5 Homo sapiens (Human) 1133 osteoclast fusion [GO:0072675]; oxidation-reduction process [GO:0055114]; podosome assembly [GO:0071800]; superoxide metabolic process [GO:0006801] GO:0002102; GO:0005737; GO:0006801; GO:0016176; GO:0030054; GO:0035091; GO:0042995; GO:0055114; GO:0071800; GO:0072675 0 0 0 PF00787;PF00018; Q6DIB5 CHOYP_MEG10.84.91 m.63832 sp MEG10_MOUSE 37.647 340 183 19 183 518 348 662 3.86E-39 157 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6Y1S1 CHOYP_NEMVEDRAFT_V1G82163.1.1 m.25493 sp MYD88_RAT 31.852 135 85 4 7 136 161 293 3.86E-17 79.3 MYD88_RAT reviewed Myeloid differentiation primary response protein MyD88 Myd88 Rattus norvegicus (Rat) 296 cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; establishment of endothelial intestinal barrier [GO:0090557]; immunoglobulin mediated immune response [GO:0016064]; induced systemic resistance [GO:0009682]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000338]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of inflammatory response [GO:0050727]; regulation of neutrophil migration [GO:1902622]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063]; type I interferon biosynthetic process [GO:0045351] GO:0002238; GO:0002755; GO:0005102; GO:0005121; GO:0005149; GO:0005829; GO:0005886; GO:0006954; GO:0007254; GO:0008063; GO:0009615; GO:0009682; GO:0014069; GO:0016064; GO:0019221; GO:0031663; GO:0032494; GO:0032740; GO:0032747; GO:0032755; GO:0032760; GO:0043066; GO:0043123; GO:0043234; GO:0044130; GO:0045080; GO:0045351; GO:0046330; GO:0048661; GO:0050671; GO:0050727; GO:0050830; GO:0051092; GO:0090557; GO:1902622; GO:2000338; GO:2000341 0 0 0 PF00531;PF01582; Q86X95 CHOYP_CIR1.1.2 m.16125 sp CIR1_HUMAN 56.579 228 86 4 1 217 1 226 3.86E-79 256 CIR1_HUMAN reviewed Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) (Recepin) CIR1 CIR Homo sapiens (Human) 450 "mRNA processing [GO:0006397]; negative regulation of transcription, DNA-templated [GO:0045892]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003705; GO:0003714; GO:0005634; GO:0005737; GO:0005815; GO:0006351; GO:0006397; GO:0008380; GO:0016607; GO:0045892 0 0 0 PF10197; Q8BMT9 CHOYP_HHAT.1.1 m.35551 sp HHAT_MOUSE 31.098 492 300 8 33 517 25 484 3.86E-62 215 HHAT_MOUSE reviewed Protein-cysteine N-palmitoyltransferase HHAT (EC 2.3.1.-) (Hedgehog acyltransferase) (Skinny hedgehog protein) Hhat Skn Mus musculus (Mouse) 499 multicellular organism development [GO:0007275]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein palmitoylation [GO:0018345]; smoothened signaling pathway [GO:0007224] GO:0005525; GO:0005789; GO:0007224; GO:0007275; GO:0016021; GO:0016409; GO:0018345; GO:1903955 0 0 0 PF03062; Q8C525 CHOYP_LOC100377311.10.14 m.54333 sp M21D2_MOUSE 26.786 168 115 4 174 340 162 322 3.86E-10 66.2 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8N0U4 CHOYP_BRAFLDRAFT_221105.2.2 m.18318 sp F185A_HUMAN 24.876 402 258 13 20 406 20 392 3.86E-26 112 F185A_HUMAN reviewed Protein FAM185A FAM185A Homo sapiens (Human) 392 0 GO:0005737 0 0 0 PF13349; Q8VHN7 CHOYP_BRAFLDRAFT_102479.1.1 m.8181 sp GPR98_MOUSE 41.441 111 60 3 1 111 2907 3012 3.86E-18 82.8 GPR98_MOUSE reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1) (Neurepin) (Very large G-protein coupled receptor 1) Gpr98 Kiaa0686 Mass1 Vlgr1 Mus musculus (Mouse) 6298 cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; inner ear development [GO:0048839]; inner ear receptor stereocilium organization [GO:0060122]; maintenance of organ identity [GO:0048496]; nervous system development [GO:0007399]; neurological system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; positive regulation of protein kinase A signaling [GO:0010739]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; single organismal cell-cell adhesion [GO:0016337]; visual perception [GO:0007601] GO:0002141; GO:0002142; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0007166; GO:0007399; GO:0007601; GO:0007605; GO:0009986; GO:0010739; GO:0016020; GO:0016021; GO:0016337; GO:0017022; GO:0032391; GO:0043235; GO:0045184; GO:0045494; GO:0048471; GO:0048496; GO:0048839; GO:0050877; GO:0050910; GO:0050953; GO:0060122; GO:0070062; GO:0071277; GO:1990075; GO:1990696 0 0 0 PF00002;PF03160;PF03736; Q90ZK6 CHOYP_ACVR1.1.2 m.40794 sp ACVR1_CHICK 32.642 193 100 8 4 186 20 192 3.86E-13 70.1 ACVR1_CHICK reviewed Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (Type I TGF B receptor) ACVR1 Gallus gallus (Chicken) 504 "activin receptor signaling pathway [GO:0032924]; acute inflammatory response [GO:0002526]; atrial septum primum morphogenesis [GO:0003289]; BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac muscle cell fate commitment [GO:0060923]; cell migration [GO:0016477]; cellular response to BMP stimulus [GO:0071773]; determination of left/right symmetry [GO:0007368]; embryonic heart tube morphogenesis [GO:0003143]; endocardial cushion cell fate commitment [GO:0061445]; endothelial cell activation [GO:0042118]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; mesenchymal cell differentiation [GO:0048762]; mesoderm development [GO:0007498]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of signal transduction [GO:0009968]; neural crest cell migration [GO:0001755]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; patterning of blood vessels [GO:0001569]; peptidyl-threonine phosphorylation [GO:0018107]; pharyngeal system development [GO:0060037]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of determination of dorsal identity [GO:2000017]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of ossification [GO:0030278]; smooth muscle cell differentiation [GO:0051145]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000082; GO:0001569; GO:0001702; GO:0001707; GO:0001755; GO:0002526; GO:0003143; GO:0003183; GO:0003289; GO:0004672; GO:0004674; GO:0004702; GO:0005025; GO:0005057; GO:0005524; GO:0005622; GO:0005887; GO:0006468; GO:0007179; GO:0007281; GO:0007368; GO:0007369; GO:0007498; GO:0007507; GO:0009968; GO:0010694; GO:0010718; GO:0010862; GO:0016020; GO:0016361; GO:0016477; GO:0018107; GO:0019838; GO:0030278; GO:0030335; GO:0030501; GO:0030509; GO:0030513; GO:0032924; GO:0032926; GO:0035556; GO:0042118; GO:0042803; GO:0045177; GO:0045669; GO:0045893; GO:0045944; GO:0046332; GO:0046872; GO:0048179; GO:0048185; GO:0048762; GO:0050431; GO:0051145; GO:0060037; GO:0060317; GO:0060389; GO:0060923; GO:0061445; GO:0071773; GO:2000017; GO:2001237 0 0 0 PF07714;PF08515; Q96RW7 CHOYP_UNC89.12.19 m.45144 sp HMCN1_HUMAN 23.894 339 220 13 259 584 941 1254 3.86E-10 67.8 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99M80 CHOYP_PTPRT.32.45 m.54279 sp PTPRT_MOUSE 34.12 551 305 13 504 1025 767 1288 3.86E-73 270 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9D7K5 CHOYP_SMP_039390.1.1 m.38652 sp AT5SL_MOUSE 33.005 203 130 3 79 275 51 253 3.86E-28 112 AT5SL_MOUSE reviewed ATP synthase subunit s-like protein Atp5sl Mus musculus (Mouse) 258 0 GO:0005739 0 0 0 0 Q9IA11 CHOYP_CX.1.1 m.30555 sp HXD5_HETFR 41.445 263 119 9 1 250 1 241 3.86E-43 150 HXD5_HETFR reviewed Homeobox protein Hox-D5 HOXD5 Heterodontus francisci (Horn shark) (Cestracion francisci) 252 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0007275; GO:0043565 0 0 0 PF00046; Q9JHA8 CHOYP_LOC565211.2.2 m.55017 sp VWA7_MOUSE 26.023 611 377 23 72 663 87 641 3.86E-35 148 VWA7_MOUSE reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) 891 0 GO:0005576 0 0 0 0 Q9NUV9 CHOYP_LOC100149379.2.2 m.57621 sp GIMA4_HUMAN 34.564 298 182 8 1 291 8 299 3.86E-44 159 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9QYX7 CHOYP_LOC100900518.1.1 m.60042 sp PCLO_MOUSE 26.829 246 133 8 12 211 4425 4669 3.86E-14 75.1 PCLO_MOUSE reviewed Protein piccolo (Aczonin) (Brain-derived HLMN protein) (Multidomain presynaptic cytomatrix protein) Pclo Acz Mus musculus (Mouse) 5068 cAMP-mediated signaling [GO:0019933]; cytoskeleton organization [GO:0007010]; insulin secretion [GO:0030073]; protein localization to synapse [GO:0035418]; regulation of exocytosis [GO:0017157]; synapse assembly [GO:0007416]; synaptic vesicle targeting [GO:0016080] GO:0005509; GO:0005522; GO:0005544; GO:0007010; GO:0007416; GO:0014069; GO:0016080; GO:0017157; GO:0019933; GO:0030054; GO:0030073; GO:0035418; GO:0045202; GO:0048786; GO:0070062 0 0 0 PF00168;PF00595;PF05715; Q9UBC9 CHOYP_NEMVEDRAFT_V1G112753.1.1 m.3356 sp SPRR3_HUMAN 35.088 114 74 0 21 134 39 152 3.86E-16 73.6 SPRR3_HUMAN reviewed Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin) SPRR3 SPRC Homo sapiens (Human) 169 epidermis development [GO:0008544]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; wound healing [GO:0042060] GO:0001533; GO:0005198; GO:0005737; GO:0008544; GO:0018149; GO:0030216; GO:0031424; GO:0042060; GO:0070062 0 0 0 0 Q9W7R4 CHOYP_BRAFLDRAFT_99630.6.9 m.39673 sp TEN3_DANRE 27.027 259 143 11 72 307 566 801 3.86E-06 53.9 TEN3_DANRE reviewed Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) tenm3 odz3 tnm3 Danio rerio (Zebrafish) (Brachydanio rerio) 2590 dendrite guidance [GO:0070983]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of neuron projection development [GO:0010976]; retinal ganglion cell axon guidance [GO:0031290]; self proteolysis [GO:0097264]; signal transduction [GO:0007165] GO:0007156; GO:0007165; GO:0010976; GO:0016020; GO:0016021; GO:0030424; GO:0031290; GO:0042803; GO:0046982; GO:0070983; GO:0097264 0 0 0 PF06484;PF15636; A2AVA0 CHOYP_LYAM3.3.4 m.4278 sp SVEP1_MOUSE 28.061 392 258 9 3 394 2754 3121 3.87E-43 165 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A4IF63 CHOYP_contig_004799 m.5511 sp TRIM2_BOVIN 30.508 118 78 3 306 420 627 743 3.87E-07 55.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B4PEU8 CHOYP_RS9.5.13 m.38743 sp RS9_DROYA 87.919 149 18 0 21 169 4 152 3.87E-90 264 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; F6QEU4 CHOYP_LOC100373444.58.79 m.53505 sp LIN41_XENTR 21.981 646 382 31 7 580 141 736 3.87E-09 63.5 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O02833 CHOYP_BRAFLDRAFT_78389.1.1 m.33150 sp ALS_PAPHA 28.909 550 335 5 157 706 77 570 3.87E-57 211 ALS_PAPHA reviewed Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Papio hamadryas (Hamadryas baboon) 605 cell adhesion [GO:0007155] GO:0005615; GO:0007155 0 0 0 PF13855;PF01462; O14522 CHOYP_PTPRT.13.45 m.40736 sp PTPRT_HUMAN 31.25 720 438 16 694 1367 732 1440 3.87E-84 306 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O43301 CHOYP_BRAFLDRAFT_57788.6.10 m.45495 sp HS12A_HUMAN 28.529 333 181 10 4 289 25 347 3.87E-34 134 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O60218 CHOYP_ALD2.1.1 m.55849 sp AK1BA_HUMAN 50.853 293 136 5 6 296 3 289 3.87E-92 280 AK1BA_HUMAN reviewed Aldo-keto reductase family 1 member B10 (EC 1.1.1.-) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) AKR1B10 AKR1B11 Homo sapiens (Human) 316 cellular aldehyde metabolic process [GO:0006081]; daunorubicin metabolic process [GO:0044597]; digestion [GO:0007586]; doxorubicin metabolic process [GO:0044598]; farnesol catabolic process [GO:0016488]; retinoid metabolic process [GO:0001523]; steroid metabolic process [GO:0008202] GO:0001523; GO:0001758; GO:0004033; GO:0005764; GO:0005829; GO:0006081; GO:0007586; GO:0008202; GO:0016488; GO:0044597; GO:0044598; GO:0045550; GO:0047718; GO:0070062 0 0 cd06660; PF00248; P00529 CHOYP_AGAP_AGAP000015.1.1 m.16805 sp ROS_AVISU 56.986 365 151 4 2 362 10 372 3.87E-135 409 ROS_AVISU reviewed Tyrosine-protein kinase transforming protein ros (EC 2.7.10.1) V-ROS UR2 sarcoma virus (UR2SV) (Avian sarcoma virus (strain UR2)) 402 transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0016020 0 0 0 PF07714; P08004 CHOYP_CHS2.1.1 m.63783 sp CHS1_YEAST 24.427 262 155 8 1 224 716 972 3.87E-09 63.9 CHS1_YEAST reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) CHS1 YNL192W N1404 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1131 cell separation after cytokinesis [GO:0000920]; cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0000920; GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0045009; GO:0071555 0 0 0 PF01644;PF08407; P15287 CHOYP_AGSA.1.1 m.5200 sp AGSA_APLCA 29.767 514 310 15 30 525 33 513 3.87E-56 201 AGSA_APLCA reviewed Adenosine deaminase AGSA (EC 3.5.4.4) (Atrial gland-specific antigen) (AGSA) (Mollusk-derived growth factor) (MDGF) 0 Aplysia californica (California sea hare) 525 0 GO:0004000; GO:0005615; GO:0046872 0 0 0 PF00962;PF08451; P16157 CHOYP_TVAG_062850.1.1 m.1296 sp ANK1_HUMAN 28.736 261 178 3 47 304 321 576 3.87E-24 108 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P55865 CHOYP_CAS1A.1.1 m.62820 sp CAS1A_XENLA 25 248 147 11 120 336 143 382 3.87E-09 60.8 CAS1A_XENLA reviewed Caspase-1-A (CASP-1-A) (EC 3.4.22.36) (Interleukin-1 beta convertase homolog A) (xICE-A) casp1-a casp1a Xenopus laevis (African clawed frog) 386 apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005737; GO:0006915; GO:0042981 0 0 0 PF00619; Q10663 CHOYP_LOC577637.1.1 m.4827 sp GCP_CAEEL 31.677 161 99 4 58 209 456 614 3.87E-19 89 GCP_CAEEL reviewed Bifunctional glyoxylate cycle protein (Gex-3-interacting protein 7) [Includes: Isocitrate lyase (ICL) (Isocitrase) (Isocitratase) (EC 4.1.3.1); Malate synthase (EC 2.3.3.9)] icl-1 gei-7 C05E4.9 Caenorhabditis elegans 968 determination of adult lifespan [GO:0008340]; glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] GO:0004451; GO:0004474; GO:0005739; GO:0006097; GO:0006099; GO:0008340; GO:0046912 PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.; PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. 0 cd00727; PF00463;PF01274; Q16820 CHOYP_NEMVEDRAFT_V1G157638.1.1 m.31214 sp MEP1B_HUMAN 28.778 483 251 21 9 454 1 427 3.87E-44 167 MEP1B_HUMAN reviewed Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta) MEP1B Homo sapiens (Human) 701 digestion [GO:0007586]; inflammatory response [GO:0006954]; toxin transport [GO:1901998] GO:0004222; GO:0005615; GO:0005886; GO:0005887; GO:0006954; GO:0007586; GO:0008270; GO:1901998 0 0 cd06263; PF01400;PF00629; Q1LUQ4 CHOYP_DANA_GF25282.1.1 m.7124 sp MFD6A_DANRE 29.771 262 152 6 25 264 445 696 3.87E-26 111 MFD6A_DANRE reviewed Major facilitator superfamily domain-containing protein 6-A (Macrophage MHC class I receptor 2 homolog A) mfsd6a mfsd6 mmr2 si:dkey-188p4.2 Danio rerio (Zebrafish) (Brachydanio rerio) 793 0 GO:0016021 0 0 cd06174; PF12832; Q20930 CHOYP_ADAMTS12.2.2 m.51523 sp MIG17_CAEEL 35.124 242 135 13 290 516 226 460 3.87E-29 126 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q2ABP2 CHOYP_BRAFLDRAFT_204871.1.1 m.66068 sp PGAP2_CRIGR 47.552 143 69 2 18 157 112 251 3.87E-34 123 PGAP2_CRIGR reviewed Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1) Pgap2 Frag1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 254 GPI anchor biosynthetic process [GO:0006506] GO:0000139; GO:0005789; GO:0006506; GO:0008565; GO:0016021 0 0 0 PF10277; Q2HJ94 CHOYP_DNJA2.1.2 m.21835 sp DNJA2_BOVIN 51.643 426 187 5 32 456 5 412 3.87E-136 400 DNJA2_BOVIN reviewed DnaJ homolog subfamily A member 2 DNAJA2 Bos taurus (Bovine) 412 protein refolding [GO:0042026]; response to heat [GO:0009408] GO:0005524; GO:0005829; GO:0009408; GO:0016020; GO:0042026; GO:0046872; GO:0070062 0 0 cd06257; PF00226;PF01556;PF00684; Q2VLG6 CHOYP_LOC100889653.1.1 m.67036 sp C163A_CANLF 42.282 149 76 4 8 151 213 356 3.87E-26 106 C163A_CANLF reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis lupus familiaris (Dog) (Canis familiaris) 1133 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q58863 CHOYP_LOC100368614.3.3 m.38113 sp Y1468_METJA 32.653 98 62 2 48 144 752 846 3.87E-06 53.1 Y1468_METJA reviewed Uncharacterized protein MJ1468 MJ1468 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 1009 0 GO:0005886; GO:0016021 0 0 0 PF00801; Q5VVX9 CHOYP_LOC100370245.1.1 m.35057 sp UBE2U_HUMAN 31.909 351 180 7 1 326 1 317 3.87E-42 151 UBE2U_HUMAN reviewed Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U) UBE2U Homo sapiens (Human) 321 DNA repair [GO:0006281]; histone ubiquitination [GO:0016574]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0000790; GO:0005524; GO:0005737; GO:0006281; GO:0016574; GO:0031625; GO:0033503; GO:0043161; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q6GPD0 CHOYP_LOC100889543.1.1 m.66587 sp RHG32_XENLA 51.502 233 111 2 86 317 98 329 3.87E-76 257 RHG32_XENLA reviewed Rho GTPase-activating protein 32 (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) arhgap32 rics Xenopus laevis (African clawed frog) 1940 signal transduction [GO:0007165] GO:0005096; GO:0005737; GO:0005886; GO:0007165; GO:0035091 0 0 0 PF00620;PF07653; Q6PEC4 CHOYP_LOC100862999.1.1 m.11759 sp SKP1_RAT 85.89 163 22 1 1 162 1 163 3.87E-89 259 SKP1_RAT reviewed S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1) Skp1 Skp1a Rattus norvegicus (Rat) 163 protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005829; GO:0016567; GO:0019005; GO:0031146; GO:0031467 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01466;PF03931; Q6R7J4 CHOYP_Y028.1.1 m.30881 sp Y029_OSHVF 100 201 0 0 1 201 1 201 3.87E-147 409 Y029_OSHVF reviewed Uncharacterized protein ORF29 ORF29 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 201 0 0 0 0 0 0 Q8L7W2 CHOYP_LOC100633143.1.1 m.14679 sp NUDT8_ARATH 38.14 215 130 3 13 226 101 313 3.87E-47 164 NUDT8_ARATH reviewed Nudix hydrolase 8 (AtNUDT8) (EC 3.6.1.-) NUDT8 NUDX8 At5g47240 MQL5.10 Arabidopsis thaliana (Mouse-ear cress) 369 response to wounding [GO:0009611] GO:0009611; GO:0016787; GO:0046872 0 0 0 PF00293; Q99572 CHOYP_LOC585718.2.2 m.40232 sp P2RX7_HUMAN 37.19 121 70 3 126 241 472 591 3.87E-17 83.6 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; Q99816 CHOYP_TS101.2.4 m.44468 sp TS101_HUMAN 54.167 144 66 0 9 152 1 144 3.87E-57 192 TS101_HUMAN reviewed Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) TSG101 Homo sapiens (Human) 390 "autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell cycle arrest [GO:0007050]; cell division [GO:0051301]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; intracellular transport of virus [GO:0075733]; keratinocyte differentiation [GO:0030216]; multivesicular body assembly [GO:0036258]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein monoubiquitination [GO:0006513]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]" GO:0000813; GO:0001558; GO:0003677; GO:0003714; GO:0005730; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005771; GO:0005886; GO:0006513; GO:0006914; GO:0007050; GO:0008285; GO:0008333; GO:0010008; GO:0015031; GO:0016197; GO:0019058; GO:0030216; GO:0030374; GO:0031625; GO:0031902; GO:0036258; GO:0039702; GO:0042803; GO:0043130; GO:0043162; GO:0043405; GO:0045892; GO:0046755; GO:0046790; GO:0048306; GO:0048524; GO:0051301; GO:0070062; GO:0075733; GO:0097352; GO:1902188; GO:1903543; GO:1903551; GO:1903772; GO:1903774; GO:2000397 0 0 0 PF05743;PF09454; Q9BX70 CHOYP_LOC100184864.1.1 m.40827 sp BTBD2_HUMAN 31.095 402 245 12 6 388 94 482 3.87E-48 175 BTBD2_HUMAN reviewed BTB/POZ domain-containing protein 2 BTBD2 Homo sapiens (Human) 525 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of proteolysis [GO:0030162] GO:0000932; GO:0019005; GO:0030162; GO:0031625; GO:0042787; GO:0043161 0 0 0 PF07707;PF00651;PF08005; Q9BXF9 CHOYP_TEKT5.1.1 m.60033 sp TEKT3_HUMAN 47.863 234 104 8 1 234 1 216 3.87E-59 197 TEKT3_HUMAN reviewed Tektin-3 TEKT3 Homo sapiens (Human) 490 cilium morphogenesis [GO:0060271]; regulation of fertilization [GO:0080154]; sperm motility [GO:0030317] GO:0002080; GO:0005634; GO:0005874; GO:0030317; GO:0036126; GO:0060271; GO:0070062; GO:0080154 0 0 0 0 Q9CWV0 CHOYP_LOC100367139.1.1 m.24907 sp MASU1_MOUSE 43.81 105 57 1 149 253 86 188 3.87E-26 106 MASU1_MOUSE reviewed Mitochondrial assembly of ribosomal large subunit protein 1 Malsu1 Mus musculus (Mouse) 228 negative regulation of mitochondrial translation [GO:0070130]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of translation [GO:0017148]; ribosomal large subunit biogenesis [GO:0042273] GO:0005737; GO:0005739; GO:0005759; GO:0017148; GO:0042273; GO:0043023; GO:0070130; GO:0090071 0 0 0 0 Q9D5R3 CHOYP_LOC100375266.1.1 m.6535 sp CEP83_MOUSE 37.446 697 411 11 75 759 4 687 3.87E-127 399 CEP83_MOUSE reviewed Centrosomal protein of 83 kDa (Cep83) (Coiled-coil domain-containing protein 41) Cep83 Ccdc41 Mus musculus (Mouse) 692 cilium assembly [GO:0042384]; establishment of centrosome localization [GO:0051660]; protein localization to centrosome [GO:0071539]; vesicle docking [GO:0048278] GO:0005794; GO:0005814; GO:0042384; GO:0048278; GO:0051660; GO:0071539; GO:0097539 0 0 0 0 Q9UH92 CHOYP_BRAFLDRAFT_84752.1.1 m.30903 sp MLX_HUMAN 64.078 206 64 3 29 230 94 293 3.87E-81 247 MLX_HUMAN reviewed Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) MLX BHLHD13 TCFL4 Homo sapiens (Human) 298 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0001227; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008134; GO:0042803; GO:0045892; GO:0046982 0 0 0 PF00010; A6H603 CHOYP_LOC100377670.1.2 m.17749 sp NWD1_MOUSE 28.272 191 122 5 1 178 715 903 3.88E-16 82 NWD1_MOUSE reviewed NACHT domain- and WD repeat-containing protein 1 Nwd1 Mus musculus (Mouse) 1563 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; D4A2Z2 CHOYP_EPPI.1.2 m.42116 sp EPPI_RAT 41.026 117 53 5 24 140 30 130 3.88E-16 73.2 EPPI_RAT reviewed Eppin (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1) Eppin Spinlw1 Rattus norvegicus (Rat) 134 defense response to bacterium [GO:0042742]; negative regulation of peptidase activity [GO:0010466] GO:0001669; GO:0004867; GO:0005576; GO:0010466; GO:0042742 0 0 0 PF00014;PF00095; O42101 CHOYP_NR5A2.1.1 m.63245 sp NR5A2_CHICK 46.183 524 234 11 26 529 5 500 3.88E-142 422 NR5A2_CHICK reviewed Nuclear receptor subfamily 5 group A member 2 (FTF/LRH-1) (OR2.0) NR5A2 Gallus gallus (Chicken) 501 "hormone-mediated signaling pathway [GO:0009755]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; tissue development [GO:0009888]; transcription, DNA-templated [GO:0006351]" GO:0000976; GO:0003682; GO:0003707; GO:0004879; GO:0006351; GO:0008270; GO:0009755; GO:0009888; GO:0045944; GO:0090575 0 0 0 PF00104;PF00105; O43900 CHOYP_LOC100160412.1.2 m.1214 sp PRIC3_HUMAN 40.856 257 145 4 35 286 22 276 3.88E-57 200 PRIC3_HUMAN reviewed Prickle-like protein 3 (LIM domain only protein 6) (LMO-6) (Triple LIM domain protein 6) PRICKLE3 LMO6 Homo sapiens (Human) 615 0 GO:0008270 0 0 cd09415;cd09418;cd09420;cd09827; PF00412;PF06297; O57429 CHOYP_LOC100114408.1.1 m.51511 sp UBP2_CHICK 53.198 344 154 7 264 603 17 357 3.88E-121 365 UBP2_CHICK reviewed Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Gallus gallus (Chicken) 357 protein deubiquitination [GO:0016579]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0016579; GO:0046872; GO:0048471; GO:0048511 0 0 0 PF00443; O75947 CHOYP_ATP5H.1.1 m.22927 sp ATP5H_HUMAN 24.832 149 110 1 28 176 5 151 3.88E-08 54.7 ATP5H_HUMAN reviewed "ATP synthase subunit d, mitochondrial (ATPase subunit d)" ATP5H My032 Homo sapiens (Human) 161 ATP biosynthetic process [GO:0006754]; ATP synthesis coupled proton transport [GO:0015986]; mitochondrial ATP synthesis coupled proton transport [GO:0042776] GO:0000274; GO:0005654; GO:0005737; GO:0005739; GO:0005743; GO:0005753; GO:0006754; GO:0015078; GO:0015986; GO:0022857; GO:0042776; GO:0070062 0 0 0 0 O95236 CHOYP_contig_051077 m.60930 sp APOL3_HUMAN 35.366 82 53 0 606 687 173 254 3.88E-07 56.6 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; O97758 CHOYP_BRAFLDRAFT_93411.2.3 m.46656 sp ZO1_CANLF 46.599 397 203 6 30 423 413 803 3.88E-98 346 ZO1_CANLF reviewed Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) TJP1 ZO1 Canis lupus familiaris (Dog) (Canis familiaris) 1769 bicellular tight junction assembly [GO:0070830]; cellular response to calcium ion [GO:0071277] GO:0005886; GO:0005911; GO:0005921; GO:0005923; GO:0009986; GO:0031410; GO:0070830; GO:0071277 0 0 0 PF00625;PF00595;PF07653;PF00791; P0CM16 CHOYP_SMP_088650.3.3 m.34901 sp ARF_CRYNJ 45.349 172 91 1 5 176 11 179 3.88E-48 158 ARF_CRYNJ reviewed ADP-ribosylation factor ARF CNG03220 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) 182 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; P13595 CHOYP_contig_002150 m.2333 sp NCAM1_MOUSE 30.159 126 64 5 2 125 683 786 3.88E-12 65.5 NCAM1_MOUSE reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56) Ncam1 Ncam Mus musculus (Mouse) 1115 axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; homotypic cell-cell adhesion [GO:0034109]; neuron projection development [GO:0031175]; positive regulation of calcium-mediated signaling [GO:0050850]; regulation of exocyst assembly [GO:0001928]; regulation of synaptic plasticity [GO:0048167] GO:0001928; GO:0005737; GO:0005886; GO:0005911; GO:0007166; GO:0007411; GO:0008201; GO:0009897; GO:0009986; GO:0016020; GO:0016021; GO:0030424; GO:0030426; GO:0031175; GO:0031225; GO:0034109; GO:0043025; GO:0043209; GO:0048167; GO:0050850; GO:0070062 0 0 0 PF00041;PF07679; P16157 CHOYP_TVAG_168010.18.45 m.37670 sp ANK1_HUMAN 32.507 363 193 4 8 318 164 526 3.88E-45 169 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22366 CHOYP_MYD88.6.7 m.50176 sp MYD88_MOUSE 36.296 135 80 3 56 186 161 293 3.88E-20 89.4 MYD88_MOUSE reviewed Myeloid differentiation primary response protein MyD88 Myd88 Mus musculus (Mouse) 296 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell surface receptor signaling pathway [GO:0007166]; cytokine-mediated signaling pathway [GO:0019221]; defense response to Gram-positive bacterium [GO:0050830]; establishment of endothelial intestinal barrier [GO:0090557]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; induced systemic resistance [GO:0009682]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-17 production [GO:0032740]; positive regulation of interleukin-23 production [GO:0032747]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon production [GO:0032481]; regulation of cell proliferation [GO:0042127]; regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000338]; regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000341]; regulation of gene expression [GO:0010468]; regulation of inflammatory response [GO:0050727]; regulation of interleukin-6 production [GO:0032675]; regulation of neutrophil migration [GO:1902622]; regulation of tumor necrosis factor production [GO:0032680]; response to interleukin-1 [GO:0070555]; response to lipopolysaccharide [GO:0032496]; response to molecule of fungal origin [GO:0002238]; response to peptidoglycan [GO:0032494]; response to virus [GO:0009615]; Toll signaling pathway [GO:0008063]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; type I interferon biosynthetic process [GO:0045351] GO:0002238; GO:0002755; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0006955; GO:0007166; GO:0007178; GO:0007254; GO:0008063; GO:0009615; GO:0009682; GO:0010468; GO:0014069; GO:0016064; GO:0019221; GO:0031663; GO:0032481; GO:0032494; GO:0032496; GO:0032675; GO:0032680; GO:0032740; GO:0032747; GO:0032755; GO:0032760; GO:0042127; GO:0042802; GO:0043123; GO:0043234; GO:0044130; GO:0045080; GO:0045351; GO:0046330; GO:0048661; GO:0050671; GO:0050727; GO:0050830; GO:0051092; GO:0070555; GO:0070935; GO:0070976; GO:0090557; GO:1902622; GO:2000338; GO:2000341 0 0 0 PF00531;PF01582; Q00725 CHOYP_contig_040884 m.46489 sp SGS4_DROME 44.444 99 55 0 7 105 70 168 3.88E-09 55.5 SGS4_DROME reviewed Salivary glue protein Sgs-4 Sgs4 Sgs-4 CG12181 Drosophila melanogaster (Fruit fly) 297 0 GO:0005576 0 0 0 0 Q0VEE6 CHOYP_USO1.2.11 m.12785 sp ZN800_MOUSE 29.703 101 62 2 14 111 28 122 3.88E-09 65.1 ZN800_MOUSE reviewed Zinc finger protein 800 Znf800 Zfp800 Mus musculus (Mouse) 662 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF16622; Q14186 CHOYP_LOC594176.1.1 m.9662 sp TFDP1_HUMAN 63.533 351 101 8 55 389 1 340 3.88E-143 419 TFDP1_HUMAN reviewed Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) TFDP1 DP1 Homo sapiens (Human) 410 "cell proliferation [GO:0008283]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of fat cell proliferation [GO:0070345]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005739; GO:0006351; GO:0006357; GO:0006977; GO:0008134; GO:0008283; GO:0019904; GO:0045944; GO:0070345; GO:1900740 0 0 cd14458; PF08781;PF02319; Q26481 CHOYP_LOC100186763.2.2 m.27545 sp RL5_STYCL 83.893 149 24 0 1 149 1 149 3.88E-92 273 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q5RAT5 CHOYP_LSM12.1.1 m.24998 sp LSM12_PONAB 49.457 184 92 1 29 211 1 184 3.88E-58 184 LSM12_PONAB reviewed Protein LSM12 homolog LSM12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 195 0 0 0 0 0 PF09793; Q62210 CHOYP_BRAFLDRAFT_117715.2.3 m.57432 sp BIRC2_MOUSE 26.449 276 157 9 328 597 377 612 3.88E-20 98.2 BIRC2_MOUSE reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (Inhibitor of apoptosis protein 2) (mIAP2) Birc2 Mus musculus (Mouse) 612 "inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0009898; GO:0016740; GO:0016874; GO:0034121; GO:0035631; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0060546; GO:0070266; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000377 0 0 0 PF00653;PF00619; Q6AXZ2 CHOYP_BRAFLDRAFT_125776.2.2 m.47955 sp LRC46_RAT 48.366 153 78 1 29 181 19 170 3.88E-34 129 LRC46_RAT reviewed Leucine-rich repeat-containing protein 46 Lrrc46 Rattus norvegicus (Rat) 323 0 0 0 0 0 0 Q80VI1 CHOYP_TRI18.3.6 m.34718 sp TRI56_MOUSE 24.719 356 184 15 12 320 16 334 3.88E-15 81.6 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q8BX17 CHOYP_GEMIN5.1.2 m.18262 sp GEMI5_MOUSE 37.061 313 186 5 102 414 839 1140 3.88E-52 191 GEMI5_MOUSE reviewed Gem-associated protein 5 (Gemin5) Gemin5 Mus musculus (Mouse) 1502 spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016020; GO:0016604; GO:0017069; GO:0032797; GO:0034719; GO:0044822 0 0 0 PF12894;PF00400; Q8ITC3 CHOYP_RS19.3.12 m.15295 sp RS19_ARGIR 76.596 141 32 1 1 141 1 140 3.88E-79 233 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8IWZ3 CHOYP_LOC581927.8.27 m.24553 sp ANKH1_HUMAN 30.377 451 246 15 754 1194 207 599 3.88E-32 140 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q96NL6 CHOYP_SCLT1.1.1 m.30319 sp SCLT1_HUMAN 30.806 633 409 4 64 670 52 681 3.88E-78 267 SCLT1_HUMAN reviewed Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1) SCLT1 SAP1 Homo sapiens (Human) 688 cilium assembly [GO:0042384]; clustering of voltage-gated sodium channels [GO:0045162] GO:0005813; GO:0005814; GO:0005829; GO:0017080; GO:0042384; GO:0045162; GO:0070062; GO:0071439; GO:0097539 0 0 0 0 Q99973 CHOYP_BRAFLDRAFT_128562.4.4 m.66328 sp TEP1_HUMAN 29.634 955 639 19 25 962 1144 2082 3.88E-109 376 TEP1_HUMAN reviewed Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) 2627 telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000781; GO:0002039; GO:0003720; GO:0003723; GO:0005524; GO:0005697; GO:0005737; GO:0016363; GO:0019899; GO:0030529; GO:0070034 0 0 0 PF13271;PF05386;PF05731;PF00400; Q9ESN6 CHOYP_BRAFLDRAFT_79377.25.30 m.60168 sp TRIM2_MOUSE 27.57 214 142 6 142 349 536 742 3.88E-12 70.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9N4I4 CHOYP_RL10A.1.2 m.7633 sp RL10A_CAEEL 64.815 216 76 0 1 216 1 216 3.88E-97 284 RL10A_CAEEL reviewed 60S ribosomal protein L10a rpl-10a rpl-1 Y71F9AL.13 Caenorhabditis elegans 216 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0003735; GO:0006412; GO:0022625 0 0 cd00403; PF00687; Q9WUE3 CHOYP_LOC100181837.1.1 m.22152 sp C56D2_MOUSE 43 200 112 1 3 202 23 220 3.88E-42 145 C56D2_MOUSE reviewed Cytochrome b561 domain-containing protein 2 (Putative tumor suppressor protein 101F6) Cyb561d2 101f6 Mus musculus (Mouse) 222 oxidation-reduction process [GO:0055114] GO:0016021; GO:0046872; GO:0055114 0 0 0 PF03188; A2ASS6 CHOYP_LOC100367237.1.2 m.43812 sp TITIN_MOUSE 22.748 1943 1199 70 1018 2898 14253 15955 3.89E-75 285 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; D2GXS7 CHOYP_BRAFLDRAFT_110072.8.8 m.53279 sp TRIM2_AILME 22.353 255 180 5 138 376 492 744 3.89E-09 62 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O46644 CHOYP_TPSG1.1.1 m.29569 sp CELA1_MACFA 34.138 290 139 11 119 401 20 264 3.89E-41 149 CELA1_MACFA reviewed Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) CELA1 ELA1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 266 0 GO:0004252; GO:0005576; GO:0046872 0 0 cd00190; PF00089; P10079 CHOYP_LOC100634060.35.37 m.65892 sp FBP1_STRPU 55.109 274 123 0 1 274 180 453 3.89E-91 294 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P49013 CHOYP_LOC100634060.27.37 m.62004 sp FBP3_STRPU 52.518 139 66 0 1 139 188 326 3.89E-42 149 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; Q03348 CHOYP_PTPRC.12.14 m.49475 sp PTPRA_RAT 31.837 490 300 14 278 749 142 615 3.89E-60 220 PTPRA_RAT reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) 796 oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714] GO:0004725; GO:0005886; GO:0016021; GO:0032403; GO:0043231; GO:0048709; GO:0048714 0 0 0 PF00102; Q05909 CHOYP_LOC662019.2.2 m.32392 sp PTPRG_MOUSE 25.604 207 143 5 10 207 1179 1383 3.89E-10 62 PTPRG_MOUSE reviewed Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) Ptprg Mus musculus (Mouse) 1442 negative regulation of epithelial cell migration [GO:0010633]; toxin transport [GO:1901998] GO:0004725; GO:0010633; GO:0016021; GO:0042802; GO:0070062; GO:1901998 0 0 0 PF00194;PF00041;PF00102; Q19958 CHOYP_BND7A.1.1 m.56687 sp STO2_CAEEL 76.966 178 41 0 165 342 121 298 3.89E-100 303 STO2_CAEEL reviewed Stomatin-2 sto-2 F32A6.5 Caenorhabditis elegans 375 0 GO:0016021 0 0 0 PF01145; Q19QU3 CHOYP_BRAFLDRAFT_150340.4.4 m.53424 sp ZRAB2_PIG 58.621 145 37 3 21 165 6 127 3.89E-51 173 ZRAB2_PIG reviewed Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) ZRANB2 ZNF265 Sus scrofa (Pig) 328 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0006397; GO:0008270; GO:0008380; GO:0044822 0 0 0 PF00641; Q3MI00 CHOYP_LOC100372334.1.1 m.723 sp DNJB1_BOVIN 56.061 66 29 0 1 66 1 66 3.89E-15 80.5 DNJB1_BOVIN reviewed DnaJ homolog subfamily B member 1 DNAJB1 Bos taurus (Bovine) 340 chaperone cofactor-dependent protein refolding [GO:0070389]; chaperone mediated protein folding requiring cofactor [GO:0051085]; negative regulation of inclusion body assembly [GO:0090084] GO:0001671; GO:0005730; GO:0005829; GO:0051085; GO:0070062; GO:0070389; GO:0090084 0 0 cd06257; PF00226;PF01556; Q5I0K7 CHOYP_BRAFLDRAFT_115464.2.2 m.41511 sp ALG13_RAT 54.938 162 68 3 36 194 5 164 3.89E-55 175 ALG13_RAT reviewed UDP-N-acetylglucosamine transferase subunit ALG13 homolog (EC 2.4.1.141) (Glycosyltransferase 28 domain-containing protein 1) Alg13 Glt28d1 Rattus norvegicus (Rat) 165 0 GO:0004577; GO:0005783 0 0 0 PF04101; Q5SVQ8 CHOYP_LOC100690119.1.1 m.19413 sp ZBT41_HUMAN 36.17 94 53 3 181 274 664 750 3.89E-10 63.9 ZBT41_HUMAN reviewed Zinc finger and BTB domain-containing protein 41 ZBTB41 FRBZ1 Homo sapiens (Human) 909 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF13912; Q803U7 CHOYP_EXO1.2.2 m.64758 sp EXO1_DANRE 52.62 439 183 8 1 420 1 433 3.89E-146 452 EXO1_DANRE reviewed Exonuclease 1 (EC 3.1.-.-) (Exonuclease I) exo1 zgc:55521 Danio rerio (Zebrafish) (Brachydanio rerio) 806 DNA recombination [GO:0006310]; mismatch repair [GO:0006298] GO:0003677; GO:0005634; GO:0006298; GO:0006310; GO:0045145; GO:0046872; GO:0048256 0 0 0 PF00867;PF00752; Q8K0Q5 CHOYP_RHG18.1.1 m.24618 sp RHG18_MOUSE 39.757 659 312 18 9 651 72 661 3.89E-129 398 RHG18_MOUSE reviewed Rho GTPase-activating protein 18 (Rho-type GTPase-activating protein 18) Arhgap18 Mus musculus (Mouse) 663 regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264] GO:0005096; GO:0005737; GO:0007264; GO:0008360; GO:0030833; GO:0032956; GO:0051056; GO:2000145 0 0 0 PF00620; Q8N3Y1 CHOYP_LOC100371688.1.1 m.18773 sp FBXW8_HUMAN 35.992 514 308 13 147 650 96 598 3.89E-100 321 FBXW8_HUMAN reviewed F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29) FBXW8 FBW6 FBW8 FBX29 FBXO29 FBXW6 Homo sapiens (Human) 598 cell proliferation [GO:0008283]; Golgi organization [GO:0007030]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of dendrite morphogenesis [GO:0050775]; protein ubiquitination [GO:0016567]; spongiotrophoblast layer development [GO:0060712] GO:0005737; GO:0005794; GO:0007030; GO:0008283; GO:0016567; GO:0019005; GO:0031467; GO:0048471; GO:0050775; GO:0060712; GO:0060716 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; Q8QGX4 CHOYP_NEMVEDRAFT_V1G126379.1.2 m.282 sp PRKDC_CHICK 34.232 371 228 7 1 362 1103 1466 3.89E-58 207 PRKDC_CHICK reviewed DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC XRCC7 Gallus gallus (Chicken) 4134 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431] GO:0000724; GO:0003677; GO:0004677; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006281; GO:0006303; GO:0016301; GO:0070419; GO:0072431 0 0 0 PF02259;PF02260;PF08163;PF00454; Q9R062 CHOYP_LOC656402.1.1 m.62053 sp GLYG_MOUSE 52.698 315 127 6 17 326 4 301 3.89E-106 324 GLYG_MOUSE reviewed Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) Gyg1 Gyg Mus musculus (Mouse) 333 glycogen biosynthetic process [GO:0005978] GO:0005978; GO:0008466; GO:0016020; GO:0046872; GO:0070062 PATHWAY: Glycan biosynthesis; glycogen biosynthesis. 0 0 PF01501; Q9VCA8 CHOYP_LOC100641396.7.27 m.32816 sp ANKHM_DROME 30.769 546 320 17 14 532 523 1037 3.89E-55 209 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; A4IF63 CHOYP_LOC582174.3.16 m.20481 sp TRIM2_BOVIN 25.974 154 103 3 29 181 600 743 3.90E-08 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B3EWZ5 CHOYP_LOC593967.2.2 m.65611 sp MLRP1_ACRMI 44.444 90 40 4 244 324 3136 3224 3.90E-10 64.7 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O08848 CHOYP_LOC100634688.5.6 m.51871 sp RO60_MOUSE 33.216 566 316 18 22 569 12 533 3.90E-84 275 RO60_MOUSE reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) Trove2 Ssa2 Mus musculus (Mouse) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0034336; GO:0046872; GO:0060271 0 0 0 PF05731; O42260 CHOYP_LOC100525675.1.1 m.25764 sp GEMI2_XENLA 43.426 251 125 3 25 268 14 254 3.90E-65 207 GEMI2_XENLA reviewed Gem-associated protein 2 (Gemin-2) (Component of gems 2) (Survival of motor neuron protein-interacting protein 1) (SMN-interacting protein 1) gemin2 sip1 Xenopus laevis (African clawed frog) 259 spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387] GO:0000245; GO:0000387; GO:0005681; GO:0005829; GO:0032797; GO:0034719; GO:0097504 0 0 0 0 P02504 CHOYP_LOC100705966.1.1 m.45957 sp CRYAA_CHICK 34.94 83 53 1 54 135 69 151 3.90E-07 52 CRYAA_CHICK reviewed Alpha-crystallin A chain CRYAA Gallus gallus (Chicken) 173 actin filament organization [GO:0007015]; apoptotic process involved in morphogenesis [GO:0060561]; embryonic camera-type eye morphogenesis [GO:0048596]; lens fiber cell morphogenesis [GO:0070309]; microtubule-based process [GO:0007017]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of gene expression [GO:0010629]; negative regulation of intracellular transport [GO:0032387]; positive regulation of cell growth [GO:0030307]; positive regulation of protein phosphorylation [GO:0001934]; protein homooligomerization [GO:0051260]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to UV-A [GO:0070141]; tubulin complex assembly [GO:0007021]; visual perception [GO:0007601] GO:0001666; GO:0001934; GO:0005212; GO:0005634; GO:0005737; GO:0007005; GO:0007015; GO:0007017; GO:0007021; GO:0007601; GO:0010629; GO:0030307; GO:0032387; GO:0042542; GO:0042802; GO:0043066; GO:0043154; GO:0046872; GO:0048596; GO:0051082; GO:0051260; GO:0060561; GO:0070062; GO:0070141; GO:0070309 0 0 0 PF00525;PF00011; P10090 CHOYP_LOC100374352.2.3 m.28015 sp WHITE_DROME 52.358 212 98 2 11 220 88 298 3.90E-69 226 WHITE_DROME reviewed Protein white w CG2759 Drosophila melanogaster (Fruit fly) 687 cellular biogenic amine biosynthetic process [GO:0042401]; cGMP transport [GO:0070731]; compound eye pigmentation [GO:0048072]; eye pigment metabolic process [GO:0042441]; eye pigment precursor transport [GO:0006856]; gravitaxis [GO:0042332]; male courtship behavior [GO:0008049]; memory [GO:0007613]; ommochrome biosynthetic process [GO:0006727] GO:0004888; GO:0005524; GO:0005886; GO:0006727; GO:0006856; GO:0007613; GO:0008049; GO:0016021; GO:0031409; GO:0031410; GO:0042332; GO:0042401; GO:0042441; GO:0042626; GO:0048072; GO:0070731 0 0 0 PF01061;PF00005; P23174 CHOYP_ABCB4.1.1 m.38198 sp MDR3_CRIGR 27.976 168 78 4 18 182 2 129 3.90E-12 67.4 MDR3_CRIGR reviewed Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 3) ABCB4 PGP3 PGY3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 1281 bile acid secretion [GO:0032782]; cellular response to bile acid [GO:1903413]; lipid homeostasis [GO:0055088]; positive regulation of cholesterol transport [GO:0032376]; positive regulation of phospholipid translocation [GO:0061092]; positive regulation of phospholipid transport [GO:2001140]; response to fenofibrate [GO:1901557] GO:0005524; GO:0005737; GO:0005886; GO:0008525; GO:0008559; GO:0016021; GO:0016324; GO:0030136; GO:0032376; GO:0032782; GO:0042626; GO:0045121; GO:0055088; GO:0061092; GO:0090554; GO:1901557; GO:1903413; GO:2001140 0 0 0 PF00664;PF00005; P85521 CHOYP_DMBT1.8.34 m.16284 sp C163A_BOVIN 52.041 98 46 1 241 338 156 252 3.90E-27 115 C163A_BOVIN reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Bos taurus (Bovine) 1129 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q2NKJ3 CHOYP_LOC100729792.1.1 m.17879 sp CTC1_HUMAN 20.645 1148 736 37 127 1173 135 1208 3.90E-24 114 CTC1_HUMAN reviewed CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B) CTC1 C17orf68 Homo sapiens (Human) 1217 bone marrow development [GO:0048539]; cellular response to DNA damage stimulus [GO:0006974]; hematopoietic stem cell proliferation [GO:0071425]; multicellular organism growth [GO:0035264]; negative regulation of telomerase activity [GO:0051974]; positive regulation of DNA replication [GO:0045740]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of telomere maintenance via telomere lengthening [GO:1904356]; replicative senescence [GO:0090399]; spleen development [GO:0048536]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833]; thymus development [GO:0048538] GO:0000723; GO:0000784; GO:0003697; GO:0005634; GO:0006974; GO:0010389; GO:0010833; GO:0035264; GO:0042162; GO:0045740; GO:0048146; GO:0048536; GO:0048538; GO:0048539; GO:0051974; GO:0071425; GO:0090399; GO:0098505; GO:1904356; GO:1990879 0 0 0 PF15489; Q4R7Y8 CHOYP_LOC100374467.1.1 m.31786 sp BBOF1_MACFA 46.93 456 241 1 21 475 19 474 3.90E-135 405 BBOF1_MACFA reviewed Basal body-orientation factor 1 (Coiled-coil domain-containing protein 176) BBOF1 CCDC176 QtsA-11302 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 529 motile cilium assembly [GO:0044458] GO:0005737; GO:0036064; GO:0044458 0 0 0 PF14988; Q5ZIJ9 CHOYP_LOC100370069.6.14 m.47157 sp MIB2_CHICK 34.286 105 46 3 304 387 11 113 3.90E-08 59.7 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6NS45 CHOYP_BRAFLDRAFT_121183.6.8 m.51697 sp CCD66_MOUSE 39.098 133 81 0 584 716 438 570 3.90E-13 77.4 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q6RY07 CHOYP_BRAFLDRAFT_281651.3.8 m.12340 sp CHIA_RAT 43.737 487 253 8 7 491 6 473 3.90E-135 410 CHIA_RAT reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) 473 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532] GO:0000272; GO:0002376; GO:0002532; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0006032; GO:0006915; GO:0008061; GO:0090197 0 0 0 PF01607;PF00704; Q7T163 CHOYP_BINT_2089.1.1 m.14718 sp KDIS_DANRE 39.45 109 66 0 1 109 148 256 3.90E-19 84.3 KDIS_DANRE reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) 1672 nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; regulation of protein kinase activity [GO:0045859] GO:0005770; GO:0007399; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0045859 0 0 0 PF00023;PF12796;PF07693; Q91W39 CHOYP_ZNF91.2.4 m.10309 sp NCOA5_MOUSE 33.538 325 118 6 2 233 242 561 3.90E-36 137 NCOA5_MOUSE reviewed Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA) Ncoa5 Mus musculus (Mouse) 579 "glucose homeostasis [GO:0042593]; negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0005615; GO:0005634; GO:0006351; GO:0006355; GO:0015629; GO:0042593; GO:0044822; GO:0046627 0 0 0 0 Q96RW7 CHOYP_MXRA5.1.1 m.56769 sp HMCN1_HUMAN 26.299 308 192 14 334 629 3743 4027 3.90E-10 68.6 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BZW4 CHOYP_LOC100376054.1.1 m.12073 sp TM6S2_HUMAN 33.908 348 214 6 13 351 14 354 3.90E-65 215 TM6S2_HUMAN reviewed Transmembrane 6 superfamily member 2 TM6SF2 Homo sapiens (Human) 377 lipid metabolic process [GO:0006629]; regulation of lipid metabolic process [GO:0019216] GO:0005789; GO:0006629; GO:0016021; GO:0019216; GO:0033116 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_109857.4.15 m.14162 sp TRIM2_MOUSE 22.388 201 146 6 77 271 547 743 3.90E-06 51.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_BRAFLDRAFT_75885.3.7 m.34426 sp TRIM2_MOUSE 29.121 182 118 5 346 523 536 710 3.90E-11 69.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9LIK5 CHOYP_CALM.15.50 m.30007 sp CML11_ARATH 53.793 145 66 1 3 147 27 170 3.90E-48 155 CML11_ARATH reviewed Calmodulin-like protein 11 CML11 At3g22930 F5N5.10 Arabidopsis thaliana (Mouse-ear cress) 173 0 GO:0005509 0 0 0 PF13499; Q9LIK5 CHOYP_CALM.31.50 m.48468 sp CML11_ARATH 53.793 145 66 1 3 147 27 170 3.90E-48 155 CML11_ARATH reviewed Calmodulin-like protein 11 CML11 At3g22930 F5N5.10 Arabidopsis thaliana (Mouse-ear cress) 173 0 GO:0005509 0 0 0 PF13499; Q9UPM8 CHOYP_AP4E1.1.1 m.26717 sp AP4E1_HUMAN 27.13 446 276 10 2 408 343 778 3.90E-34 143 AP4E1_HUMAN reviewed AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) AP4E1 Homo sapiens (Human) 1137 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005905; GO:0006886; GO:0016192; GO:0030117; GO:0031904; GO:0032588 0 0 0 PF01602;PF14807; Q9W1A4 CHOYP_PHUM_PHUM308730.1.1 m.43549 sp TAMO_DROME 28.571 161 110 3 29 184 38 198 3.90E-11 69.7 TAMO_DROME reviewed Protein tamozhennic tamo CG4057 Drosophila melanogaster (Fruit fly) 797 multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005737; GO:0007275; GO:0008270; GO:0008536; GO:0015031 0 0 0 PF09409; A3AF13 CHOYP_SJAG_03429.1.1 m.14655 sp UBP26_ORYSJ 28.322 286 179 13 204 468 102 382 3.91E-11 69.3 UBP26_ORYSJ reviewed Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.4.19.12) (Deubiquitinating enzyme 26) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) UBP26 Os03g0192800 LOC_Os03g09260 OsJ_009385 Oryza sativa subsp. japonica (Rice) 1079 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005634; GO:0006511; GO:0016579 0 0 0 PF06337;PF00443; B0BN49 CHOYP_MOT8.1.2 m.16796 sp RBMX2_RAT 65 140 49 0 1 140 13 152 3.91E-63 206 RBMX2_RAT reviewed "RNA-binding motif protein, X-linked 2" Rbmx2 Rattus norvegicus (Rat) 328 "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005686; GO:0006406; GO:0044822; GO:0070274; GO:0071011; GO:0071013 0 0 0 PF00076; B5X165 CHOYP_SMG9.1.1 m.2906 sp SMG9_SALSA 43.451 481 218 9 20 458 35 503 3.91E-128 384 SMG9_SALSA reviewed Protein SMG9 (Protein smg-9 homolog) smg9 Salmo salar (Atlantic salmon) 505 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" GO:0000184 0 0 0 PF10220; O01761 CHOYP_NEMVEDRAFT_V1G242728.1.2 m.25662 sp UNC89_CAEEL 22.404 366 254 11 220 579 4422 4763 3.91E-07 58.2 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; P08842 CHOYP_ARSE.1.1 m.36966 sp STS_HUMAN 28.826 562 320 19 31 551 28 550 3.91E-54 196 STS_HUMAN reviewed Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase) STS ARSC1 Homo sapiens (Human) 583 epidermis development [GO:0008544]; female pregnancy [GO:0007565]; glycosphingolipid metabolic process [GO:0006687]; learning or memory [GO:0007611]; positive regulation of cell proliferation [GO:0008284]; post-translational protein modification [GO:0043687]; response to estrogen [GO:0043627]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; response to pH [GO:0009268]; skin development [GO:0043588]; steroid catabolic process [GO:0006706] GO:0004773; GO:0005635; GO:0005764; GO:0005768; GO:0005783; GO:0005788; GO:0005789; GO:0005794; GO:0005886; GO:0006687; GO:0006706; GO:0007565; GO:0007611; GO:0008284; GO:0008484; GO:0008544; GO:0009268; GO:0014070; GO:0016020; GO:0016021; GO:0043231; GO:0043434; GO:0043588; GO:0043627; GO:0043687; GO:0046872 0 0 0 PF00884; P47736 CHOYP_LOC100889245.2.2 m.63710 sp RPGP1_HUMAN 42.927 615 298 17 256 831 1 601 3.91E-131 412 RPGP1_HUMAN reviewed Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1) RAP1GAP KIAA0474 RAP1GA1 Homo sapiens (Human) 663 cellular response to glial cell derived neurotrophic factor [GO:1990792]; negative regulation of GTP binding [GO:1904425]; negative regulation of microvillus assembly [GO:1903697]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of thyroid gland epithelial cell proliferation [GO:1904442]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0000139; GO:0003924; GO:0005096; GO:0005769; GO:0005829; GO:0007165; GO:0016020; GO:0017016; GO:0030424; GO:0030425; GO:0042803; GO:0043025; GO:0043087; GO:0043547; GO:0045665; GO:0051056; GO:1903697; GO:1904425; GO:1904442; GO:1990792 0 0 0 PF02188;PF02145; P53459 CHOYP_ACT6.2.2 m.40475 sp ACT6_DIPDE 51.771 367 158 1 12 359 6 372 3.91E-137 398 ACT6_DIPDE reviewed Actin-6 (Fragment) ACT6 Diphyllobothrium dendriticum (Tapeworm) 373 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P62282 CHOYP_RPS11.5.5 m.66461 sp RS11_RAT 74.843 159 37 3 22 178 1 158 3.91E-83 245 RS11_RAT reviewed 40S ribosomal protein S11 Rps11 Rattus norvegicus (Rat) 158 osteoblast differentiation [GO:0001649]; translation [GO:0006412] GO:0001649; GO:0003735; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022627; GO:0044822; GO:0070062 0 0 0 PF00366;PF16205; Q09654 CHOYP_FRIS.3.11 m.39933 sp TRI23_CAEEL 24.227 194 128 6 23 203 110 297 3.91E-07 56.2 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q12263 CHOYP_GIN4.2.2 m.3832 sp GIN4_YEAST 33.333 222 125 7 16 229 78 284 3.91E-29 118 GIN4_YEAST reviewed Serine/threonine-protein kinase GIN4 (EC 2.7.11.1) (Growth inhibitory protein 4) GIN4 YDR507C D9719.13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1142 budding cell bud growth [GO:0007117]; intracellular signal transduction [GO:0035556]; morphogenesis checkpoint [GO:0044879]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; septin ring assembly [GO:0000921] GO:0000921; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005935; GO:0006468; GO:0007117; GO:0035556; GO:0044879; GO:0046777 0 0 0 PF16797;PF00069; Q3T0B6 CHOYP_LOC100072802.1.1 m.27280 sp C1QBP_BOVIN 33.673 196 113 6 94 275 82 274 3.91E-20 90.5 C1QBP_BOVIN reviewed "Complement component 1 Q subcomponent-binding protein, mitochondrial" C1QBP Bos taurus (Bovine) 278 "apoptotic process [GO:0006915]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; mature ribosome assembly [GO:0042256]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001849; GO:0003714; GO:0003729; GO:0005540; GO:0005576; GO:0005634; GO:0005730; GO:0005737; GO:0005759; GO:0005829; GO:0005886; GO:0006351; GO:0006397; GO:0006915; GO:0006958; GO:0008380; GO:0009986; GO:0014065; GO:0030449; GO:0030984; GO:0031690; GO:0032689; GO:0032695; GO:0039534; GO:0039536; GO:0042256; GO:0043065; GO:0043234; GO:0045087; GO:0045785; GO:0048025; GO:0050687; GO:0051897; GO:0070131; GO:0090023; GO:0097177; GO:1900026; GO:1901165; GO:2000510 0 0 0 PF02330; Q52KI8 CHOYP_SRRM1.2.3 m.38052 sp SRRM1_MOUSE 54.545 99 41 3 3 101 66 160 3.91E-23 110 SRRM1_MOUSE reviewed Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101) Srrm1 Pop101 Mus musculus (Mouse) 946 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0003677; GO:0005681; GO:0016363; GO:0016607 0 0 0 PF01480; Q5ND28 CHOYP_BM1_57400.2.7 m.24538 sp SREC_MOUSE 40.807 223 112 10 219 435 212 420 3.91E-31 130 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q6DIQ3 CHOYP_BRAFLDRAFT_124389.1.1 m.12573 sp PP1R7_XENTR 31.481 162 97 2 104 265 73 220 3.91E-12 70.5 PP1R7_XENTR reviewed Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22) ppp1r7 sds22 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 346 0 GO:0005634 0 0 0 PF12799; Q7ZU45 CHOYP_LOC581183.1.1 m.49767 sp TTC25_DANRE 48.889 495 241 3 1 492 1 486 3.91E-166 485 TTC25_DANRE reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) 486 cilium assembly [GO:0042384]; determination of heart left/right asymmetry [GO:0061371]; otolith morphogenesis [GO:0032474] GO:0032474; GO:0042384; GO:0061371 0 0 0 0 Q805B4 CHOYP_TISDB.2.2 m.56892 sp TISDB_XENLA 50 210 73 9 1 184 1 204 3.91E-50 172 TISDB_XENLA reviewed "Zinc finger protein 36, C3H1 type-like 2-B (CCCH zinc finger protein 3-B) (XC3H-3b)" zfp36l2-B zfp36l2 Xenopus laevis (African clawed frog) 364 "3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; MAPK cascade [GO:0000165]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of stem cell differentiation [GO:2000737]; nephron tubule development [GO:0072080]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; pronephric nephron tubule development [GO:0039020]; pronephros development [GO:0048793]; regulation of mRNA stability [GO:0043488]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]" GO:0000165; GO:0000288; GO:0003677; GO:0005634; GO:0005737; GO:0006402; GO:0030097; GO:0031086; GO:0035019; GO:0035925; GO:0039020; GO:0043488; GO:0044344; GO:0045599; GO:0046872; GO:0048103; GO:0048793; GO:0060216; GO:0061158; GO:0070371; GO:0071356; GO:0071364; GO:0071385; GO:0071560; GO:0072080; GO:0097011; GO:1900153; GO:1904628; GO:2000737 0 0 0 PF04553;PF00642; Q80V70 CHOYP_MEG10.53.91 m.47464 sp MEGF6_MOUSE 42.105 76 42 1 194 269 819 892 3.91E-10 65.9 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8JG30 CHOYP_LOC100717261.1.1 m.51839 sp ST1B1_CHICK 39.326 267 143 6 45 296 34 296 3.91E-57 188 ST1B1_CHICK reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 SULT1B Gallus gallus (Chicken) 296 steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0005737; GO:0006805; GO:0008146; GO:0008202; GO:0042403; GO:0051923 0 0 0 PF00685; Q8WZA1 CHOYP_M70.4.1.1 m.33169 sp PMGT1_HUMAN 27.323 538 359 13 288 810 111 631 3.91E-56 207 PMGT1_HUMAN reviewed "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) (EC 2.4.1.-) (UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2) (GnT I.2)" POMGNT1 MGAT1.2 UNQ746/PRO1475 Homo sapiens (Human) 660 protein O-linked glycosylation [GO:0006493] GO:0000139; GO:0006493; GO:0016021; GO:0047223 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03071; Q90673 CHOYP_LOC408511.1.1 m.13804 sp PRLD1_CHICK 41.951 205 112 4 60 261 3 203 3.91E-45 154 PRLD1_CHICK reviewed "PRELI domain-containing protein 1, mitochondrial (Px19-like protein)" PRELID1 Gallus gallus (Chicken) 215 apoptotic process [GO:0006915] GO:0005739; GO:0005758; GO:0006915; GO:1990050 0 0 0 PF04707; Q99996 CHOYP_AKAP9.1.9 m.3207 sp AKAP9_HUMAN 44.828 58 28 1 37 94 3584 3637 3.91E-06 47 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9BRZ2 CHOYP_LOC100373888.6.9 m.60341 sp TRI56_HUMAN 21.379 290 182 9 1 268 1 266 3.91E-11 68.9 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9H0J4 CHOYP_CP096.1.1 m.35853 sp QRIC2_HUMAN 33.038 451 202 15 330 704 1227 1653 3.91E-54 206 QRIC2_HUMAN reviewed Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 0 0 0 0 0 PF16043; Q9H4K7 CHOYP_LOC100544834.1.1 m.11061 sp MTG2_HUMAN 52.778 324 152 1 66 389 70 392 3.91E-99 303 MTG2_HUMAN reviewed Mitochondrial ribosome-associated GTPase 2 (GTP-binding protein 5) (Protein obg homolog 1) (ObgH1) MTG2 GTPBP5 OBGH1 Homo sapiens (Human) 406 regulation of mitochondrial translation [GO:0070129]; regulation of respiratory system process [GO:0044065]; ribosome biogenesis [GO:0042254] GO:0000287; GO:0003924; GO:0005525; GO:0005743; GO:0005759; GO:0005761; GO:0042254; GO:0044065; GO:0070129 0 0 0 PF01018;PF01926; Q9SZJ2 CHOYP_LOC100367312.6.13 m.35168 sp GRDP2_ARATH 36.858 331 180 5 9 310 12 342 3.91E-57 213 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; Q9Y2I1 CHOYP_NISCH.1.2 m.17955 sp NISCH_HUMAN 47.109 467 237 3 4 461 7 472 3.91E-123 422 NISCH_HUMAN reviewed Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) NISCH IRAS KIAA0975 Homo sapiens (Human) 1504 "actin cytoskeleton organization [GO:0030036]; apoptotic process [GO:0006915]; glucose metabolic process [GO:0006006]; negative regulation of cell migration [GO:0030336]; norepinephrine secretion [GO:0048243]; Rac protein signal transduction [GO:0016601]; regulation of blood pressure [GO:0008217]; regulation of synaptic transmission, GABAergic [GO:0032228]" GO:0005769; GO:0005829; GO:0005886; GO:0006006; GO:0006915; GO:0008217; GO:0016020; GO:0016601; GO:0030036; GO:0030336; GO:0032228; GO:0035091; GO:0042802; GO:0048243; GO:0055037 0 0 0 PF00787; O00506 CHOYP_LOC100160839.1.1 m.53063 sp STK25_HUMAN 56.695 478 128 6 9 485 13 412 3.92E-168 484 STK25_HUMAN reviewed Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1) STK25 SOK1 YSK1 Homo sapiens (Human) 426 establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165] GO:0000139; GO:0004672; GO:0004702; GO:0005524; GO:0005737; GO:0006468; GO:0006979; GO:0007163; GO:0007165; GO:0032874; GO:0036481; GO:0042542; GO:0042803; GO:0046777; GO:0046872; GO:0050772; GO:0051645; GO:0051683; GO:0070062; GO:0090168 0 0 0 PF00069; O35127 CHOYP_C10.1.2 m.23678 sp C10_MOUSE 45.794 107 58 0 12 118 11 117 3.92E-29 105 C10_MOUSE reviewed Protein C10 Grcc10 C10 Mus musculus (Mouse) 126 0 GO:0005737 0 0 0 PF14974; O70277 CHOYP_BRAFLDRAFT_87338.2.7 m.20534 sp TRIM3_RAT 26.829 123 86 3 111 230 622 743 3.92E-07 53.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P10079 CHOYP_UIF.1.1 m.31751 sp FBP1_STRPU 42.264 530 285 12 3253 3768 373 895 3.92E-107 375 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P15941 CHOYP_contig_005425 m.6163 sp MUC1_HUMAN 38.028 213 112 6 7 201 734 944 3.92E-07 53.5 MUC1_HUMAN reviewed Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] MUC1 PUM Homo sapiens (Human) 1255 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; O-glycan processing [GO:0016266]; positive regulation of histone H4 acetylation [GO:0090240]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]" GO:0000790; GO:0000978; GO:0002039; GO:0003712; GO:0005615; GO:0005796; GO:0005887; GO:0006977; GO:0006978; GO:0010944; GO:0016266; GO:0016324; GO:0031982; GO:0033629; GO:0036003; GO:0043618; GO:0070062; GO:0090240; GO:1902166 0 0 0 PF01390; P23206 CHOYP_LOC100633390.5.5 m.64528 sp COAA1_BOVIN 31.469 143 82 6 38 179 547 674 3.92E-07 52.4 COAA1_BOVIN reviewed Collagen alpha-1(X) chain COL10A1 Bos taurus (Bovine) 674 0 GO:0005576; GO:0005578; GO:0005581 0 0 0 PF00386;PF01391; P95329 CHOYP_LOC564844.1.1 m.52071 sp MASY_MYXXD 39.114 519 291 10 66 574 27 530 3.92E-117 362 MASY_MYXXD reviewed Malate synthase (EC 2.3.3.9) mls MXAN_6441 Myxococcus xanthus (strain DK 1622) 541 glyoxylate cycle [GO:0006097]; tricarboxylic acid cycle [GO:0006099] GO:0004474; GO:0005737; GO:0006097; GO:0006099 PATHWAY: Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. 0 cd00727; PF01274; Q08623 CHOYP_LOC100027252.1.1 m.30045 sp HDHD1_HUMAN 50.216 231 112 3 1 231 1 228 3.92E-77 234 HDHD1_HUMAN reviewed Pseudouridine-5'-phosphatase (EC 3.1.3.96) (Haloacid dehalogenase-like hydrolase domain-containing protein 1) (Haloacid dehalogenase-like hydrolase domain-containing protein 1A) (Protein GS1) (Pseudouridine-5'-monophosphatase) (5'-PsiMPase) PUDP DXF68S1E FAM16AX GS1 HDHD1 HDHD1A Homo sapiens (Human) 228 nucleotide metabolic process [GO:0009117]; pyrimidine nucleoside salvage [GO:0043097] GO:0005829; GO:0009117; GO:0016787; GO:0043097; GO:0046872; GO:0070062; GO:1990738 0 0 0 PF13419; Q5PQS5 CHOYP_LOC657327.1.1 m.54812 sp CYYR1_RAT 31.373 153 76 8 8 138 13 158 3.92E-06 47 CYYR1_RAT reviewed Cysteine and tyrosine-rich protein 1 Cyyr1 Rattus norvegicus (Rat) 165 0 GO:0016021 0 0 0 PF10873; Q6AZB8 CHOYP_LOC100491442.1.2 m.5785 sp HARB1_DANRE 38.889 90 53 2 3 91 94 182 3.92E-09 55.5 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6DBQ8 CHOYP_LOC410533.1.1 m.14375 sp CPTP_DANRE 32.571 175 107 2 12 175 5 179 3.92E-28 108 CPTP_DANRE reviewed Ceramide-1-phosphate transfer protein (Glycolipid transfer protein domain-containing protein 1) (CPTP) cptp gltpd1 zgc:92000 Danio rerio (Zebrafish) (Brachydanio rerio) 211 ceramide 1-phosphate transport [GO:1902389] GO:0005543; GO:0005548; GO:0005640; GO:0005794; GO:0005829; GO:0005886; GO:0010008; GO:0017089; GO:0051861; GO:1902387; GO:1902388; GO:1902389 0 0 0 PF08718; Q6ING9 CHOYP_ISCW_ISCW023908.1.1 m.51403 sp PPM1K_XENLA 44.476 353 184 6 38 386 28 372 3.92E-103 312 PPM1K_XENLA reviewed "Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (Protein phosphatase 2C isoform kappa) (PP2C-kappa)" ppm1k Xenopus laevis (African clawed frog) 373 0 GO:0004722; GO:0005759; GO:0046872 0 0 0 PF00481; Q6NVV7 CHOYP_BRAFLDRAFT_216580.1.1 m.23385 sp CDPF1_HUMAN 46.729 107 55 2 8 113 3 108 3.92E-31 110 CDPF1_HUMAN reviewed Cysteine-rich DPF motif domain-containing protein 1 CDPF1 C22orf40 Homo sapiens (Human) 123 0 0 0 0 0 PF10170; Q7Z3G6 CHOYP_LOC100329052.1.1 m.8005 sp PRIC2_HUMAN 72.787 305 83 0 78 382 7 311 3.92E-166 503 PRIC2_HUMAN reviewed Prickle-like protein 2 PRICKLE2 Homo sapiens (Human) 844 "Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0005737; GO:0008270; GO:0031965; GO:0060071 0 0 cd09415;cd09418;cd09420;cd09827; PF00412;PF06297; Q8BRB7 CHOYP_KAT6B.2.2 m.14848 sp KAT6B_MOUSE 58.333 408 133 7 723 1128 444 816 3.92E-135 471 KAT6B_MOUSE reviewed "Histone acetyltransferase KAT6B (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Protein querkopf)" Kat6b Myst4 Mus musculus (Mouse) 1872 "histone acetylation [GO:0016573]; histone H3 acetylation [GO:0043966]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000786; GO:0003677; GO:0004402; GO:0006334; GO:0006351; GO:0008134; GO:0008270; GO:0016407; GO:0016573; GO:0043966; GO:0045892; GO:0045893; GO:0045944; GO:0070776 0 0 0 PF00538;PF01853;PF00628; Q8BXX2 CHOYP_ZN169.1.2 m.12319 sp ZBT49_MOUSE 36 75 45 2 536 608 472 545 3.92E-06 53.5 ZBT49_MOUSE reviewed Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509) Zbtb49 Zfp509 Znf509 Mus musculus (Mouse) 756 "cell cycle arrest [GO:0007050]; negative regulation of cell proliferation [GO:0008285]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0001223; GO:0005634; GO:0005737; GO:0006351; GO:0007050; GO:0008134; GO:0008285; GO:0043565; GO:0045944; GO:0046872 0 0 0 PF00651;PF00096;PF13912; Q8K0U4 CHOYP_BRAFLDRAFT_240123.2.6 m.24091 sp HS12A_MOUSE 30.128 624 375 13 8 574 54 673 3.92E-83 276 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K2J9 CHOYP_LOC100375232.2.2 m.64959 sp BTBD6_MOUSE 30.858 431 282 9 21 442 64 487 3.92E-57 199 BTBD6_MOUSE reviewed BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) 488 0 GO:0000932 0 0 0 PF07707;PF00651;PF08005; Q8R3S2 CHOYP_LOC100880511.1.1 m.40271 sp TSN33_MOUSE 38.148 270 151 5 2 266 9 267 3.92E-61 197 TSN33_MOUSE reviewed Tetraspanin-33 (Tspan-33) (Penumbra) (mPen) (Proerythroblast new membrane) Tspan33 Pen Mus musculus (Mouse) 283 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005886; GO:0005887; GO:0007166; GO:0009986; GO:0019899; GO:0045747; GO:0051604; GO:0090002; GO:0097197 0 0 0 PF00335; Q95VY2 CHOYP_TCTP.2.2 m.20355 sp TCTP_BRABE 44.275 131 68 3 28 158 1 126 3.92E-29 107 TCTP_BRABE reviewed Translationally-controlled tumor protein homolog (TCTP) 0 Branchiostoma belcheri (Amphioxus) 169 0 GO:0005737 0 0 0 PF00838; Q9M622 CHOYP_NEMVEDRAFT_V1G241157.1.1 m.55322 sp RMR1_ARATH 48.889 45 23 0 363 407 228 272 3.92E-09 61.2 RMR1_ARATH reviewed "Receptor homology region, transmembrane domain- and RING domain-containing protein 1 (AtRMR1) (ReMembR-H2 protein JR700)" RMR1 JR700 At5g66160 K2A18.24 Arabidopsis thaliana (Mouse-ear cress) 310 intracellular protein transport [GO:0006886] GO:0000139; GO:0000306; GO:0006886; GO:0008270; GO:0016021; GO:0031902; GO:0032586 0 0 0 PF02225;PF13639; B9EKR1 CHOYP_PTPREA.1.2 m.4823 sp PRPTZ_MOUSE 35.874 538 310 17 666 1174 1750 2281 3.93E-84 306 PRPTZ_MOUSE reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) Ptprz1 Mus musculus (Mouse) 2312 axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; hematopoietic progenitor cell differentiation [GO:0002244]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0002244; GO:0004725; GO:0005578; GO:0005615; GO:0005737; GO:0007409; GO:0007413; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0016021; GO:0021766; GO:0030027; GO:0030175; GO:0030424; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; F1SRY5 CHOYP_UBP37.1.1 m.15558 sp UBP37_PIG 39.958 478 243 14 230 673 298 765 3.93E-80 284 UBP37_PIG reviewed Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) USP37 Sus scrofa (Pig) 982 cell division [GO:0051301]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear division [GO:0007067]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000082; GO:0004197; GO:0004843; GO:0005634; GO:0006511; GO:0007067; GO:0035871; GO:0051301; GO:0071108 0 0 cd13312; PF00443;PF16674;PF02809; P08953 CHOYP_BRAFLDRAFT_209594.1.1 m.66286 sp TOLL_DROME 22.835 635 404 27 126 712 377 973 3.93E-11 70.5 TOLL_DROME reviewed Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) 1097 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cell adhesion [GO:0007155]; defense response [GO:0006952]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; dorsal/ventral axis specification [GO:0009950]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; mitotic cytokinesis [GO:0000281]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; regulation of hemocyte differentiation [GO:0045610]; regulation of melanization defense response [GO:0035007]; response to bacterium [GO:0009617]; response to fungus [GO:0009620]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]; zygotic specification of dorsal/ventral axis [GO:0007352] GO:0000281; GO:0002229; GO:0004888; GO:0005737; GO:0005769; GO:0005886; GO:0006952; GO:0006955; GO:0006963; GO:0006967; GO:0007155; GO:0007352; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009617; GO:0009620; GO:0009880; GO:0009897; GO:0009950; GO:0009986; GO:0016021; GO:0016201; GO:0019730; GO:0019732; GO:0019955; GO:0030097; GO:0032154; GO:0035007; GO:0035172; GO:0042802; GO:0043234; GO:0045087; GO:0045610; GO:0045944; GO:0050830; GO:0050832; GO:0070976; GO:1902875 0 0 0 PF00560;PF13306;PF13855;PF01462;PF01582; P20483 CHOYP_LOC100561262.1.1 m.16847 sp MPIP_DROME 48.677 189 88 2 125 304 272 460 3.93E-54 186 MPIP_DROME reviewed M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string) stg cdc25 CG1395 Drosophila melanogaster (Fruit fly) 479 "cell division [GO:0051301]; cell proliferation [GO:0008283]; centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of cell size [GO:0045792]; negative regulation of mitotic cell cycle [GO:0045930]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; protein dephosphorylation [GO:0006470]; regulation of cell diameter [GO:0060305]; regulation of mitotic cell cycle [GO:0007346]" GO:0000086; GO:0000278; GO:0004725; GO:0005634; GO:0005694; GO:0006470; GO:0007030; GO:0007067; GO:0007099; GO:0007346; GO:0007369; GO:0007422; GO:0007424; GO:0007488; GO:0007498; GO:0008138; GO:0008283; GO:0008284; GO:0045792; GO:0045930; GO:0045931; GO:0045977; GO:0046331; GO:0051301; GO:0060305 0 0 0 PF00581; P84316 CHOYP_EF-1A.2.9 m.10123 sp EF1A_HELZE 82.178 101 18 0 4 104 75 175 3.93E-52 171 EF1A_HELZE reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Helicoverpa zea (Corn earworm moth) (Heliothis zea) 413 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q0IHF9 CHOYP_BRAFLDRAFT_100915.1.1 m.59227 sp SARAF_XENLA 62.676 142 52 1 7 147 1 142 3.93E-59 189 SARAF_XENLA reviewed Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (Transmembrane protein 66) saraf tmem66 Xenopus laevis (African clawed frog) 303 calcium ion transport [GO:0006816]; regulation of store-operated calcium entry [GO:2001256] GO:0006816; GO:0030176; GO:2001256 0 0 0 PF06682; Q14517 CHOYP_contig_029613 m.33612 sp FAT1_HUMAN 24.138 696 461 28 187 836 2790 3464 3.93E-20 100 FAT1_HUMAN reviewed "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; single organismal cell-cell adhesion [GO:0016337] GO:0005509; GO:0005634; GO:0005886; GO:0005887; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016337; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q3SZZ7 CHOYP_BRAFLDRAFT_125263.2.9 m.21186 sp FGL1_BOVIN 38.246 285 141 10 82 342 31 304 3.93E-50 172 FGL1_BOVIN reviewed Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) 312 0 GO:0070062 0 0 0 PF00147; Q3YLA4 CHOYP_LOC100890300.1.2 m.20713 sp NCS1_LYMST 26.857 175 104 6 22 179 10 177 3.93E-07 53.1 NCS1_LYMST reviewed Neuronal calcium sensor 1 (NCS-1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 191 nervous system development [GO:0007399] GO:0005509; GO:0007399; GO:0030426; GO:0043204 0 0 0 PF00036;PF13499; Q5R9W6 CHOYP_TAF13.2.3 m.40888 sp TAF13_PONAB 74.49 98 25 0 37 134 27 124 3.93E-51 161 TAF13_PONAB reviewed Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18) TAF13 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 124 "regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0005634; GO:0006355; GO:0006366 0 0 cd07978; PF02269; Q6PFY8 CHOYP_LOC100373137.1.3 m.23712 sp TRI45_MOUSE 27.83 212 120 6 8 205 129 321 3.93E-11 69.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8C7Q4 CHOYP_BRAFLDRAFT_83361.1.1 m.59005 sp RBM4_MOUSE 46.212 132 67 2 41 169 77 207 3.93E-33 127 RBM4_MOUSE reviewed RNA-binding protein 4 (Lark homolog) (mLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a) Rbm4 Rbm4a Mus musculus (Mouse) 361 "cap-independent translational initiation [GO:0002190]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; enteroendocrine cell differentiation [GO:0035883]; entrainment of circadian clock by photoperiod [GO:0043153]; glucose homeostasis [GO:0042593]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; IRES-dependent translational initiation [GO:0002192]; miRNA mediated inhibition of translation [GO:0035278]; mRNA processing [GO:0006397]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation [GO:0045947]; negative regulation of translation in response to stress [GO:0032055]; pancreas development [GO:0031016]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of translation [GO:0045727]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of gene expression [GO:0010468]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of nucleocytoplasmic transport [GO:0046822]; response to arsenic-containing substance [GO:0046685]; RNA splicing [GO:0008380]; stress-activated MAPK cascade [GO:0051403]" GO:0000166; GO:0000381; GO:0002190; GO:0002192; GO:0003723; GO:0003729; GO:0003730; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006397; GO:0008270; GO:0008380; GO:0010468; GO:0010494; GO:0016607; GO:0017148; GO:0031016; GO:0032055; GO:0032922; GO:0035198; GO:0035278; GO:0035773; GO:0035883; GO:0036002; GO:0042593; GO:0043153; GO:0044822; GO:0045727; GO:0045947; GO:0046626; GO:0046685; GO:0046822; GO:0048471; GO:0051149; GO:0051403; GO:0097157; GO:0097158; GO:0097167 0 0 0 PF00076;PF00098; Q96GP6 CHOYP_LOC100182840.3.4 m.41905 sp SREC2_HUMAN 35.652 115 68 5 2 114 251 361 3.93E-11 61.6 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9H307 CHOYP_PININ.1.1 m.56667 sp PININ_HUMAN 39.31 290 160 7 6 289 4 283 3.93E-39 154 PININ_HUMAN reviewed Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein) PNN DRS MEMA Homo sapiens (Human) 717 "cell adhesion [GO:0007155]; mRNA splicing, via spliceosome [GO:0000398]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000398; GO:0003677; GO:0005198; GO:0005654; GO:0005882; GO:0005886; GO:0005911; GO:0006351; GO:0006355; GO:0007155; GO:0016020; GO:0016607; GO:0030057; GO:0044822; GO:0071013 0 0 0 PF04696;PF04697; Q9JK81 CHOYP_LOC100698240.3.4 m.17111 sp MYG1_MOUSE 59.292 339 135 2 2 337 27 365 3.93E-149 427 MYG1_MOUSE reviewed "UPF0160 protein MYG1, mitochondrial (Protein Gamm1)" Myg1 Mus musculus (Mouse) 380 locomotory exploration behavior [GO:0035641] GO:0005634; GO:0005654; GO:0005739; GO:0035641; GO:0070062 0 0 0 PF03690; Q9VW71 CHOYP_FAT2.2.2 m.65615 sp FAT2_DROME 29.897 388 239 14 5 384 3112 3474 3.93E-31 129 FAT2_DROME reviewed Fat-like cadherin-related tumor suppressor homolog (Protein kugelei) kug fat2 CG7749 Drosophila melanogaster (Fruit fly) 4699 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; defense response to Gram-negative bacterium [GO:0050829]; epithelium development [GO:0060429]; establishment of planar polarity of follicular epithelium [GO:0042247]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; foregut morphogenesis [GO:0007440]; germarium-derived egg chamber formation [GO:0007293]; growth of a germarium-derived egg chamber [GO:0007295]; hindgut morphogenesis [GO:0007442]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of imaginal disc growth [GO:0045571]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; positive regulation of innate immune response [GO:0045089]; salivary gland development [GO:0007431] GO:0004872; GO:0005509; GO:0005886; GO:0005887; GO:0005925; GO:0007156; GO:0007293; GO:0007295; GO:0007424; GO:0007431; GO:0007440; GO:0007442; GO:0009925; GO:0016339; GO:0030950; GO:0042247; GO:0044331; GO:0045089; GO:0045571; GO:0048477; GO:0050829; GO:0050839; GO:0060429 0 0 0 PF00028;PF02210; Q9VXX8 CHOYP_LOC100533258.5.6 m.30805 sp RL371_DROME 69.565 92 28 0 42 133 1 92 3.93E-40 132 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9W107 CHOYP_LOC576003.1.1 m.57 sp SYYM_DROME 45.111 450 239 5 18 461 16 463 3.93E-144 423 SYYM_DROME reviewed "Tyrosine--tRNA ligase, mitochondrial (EC 6.1.1.1) (Mitochondrial tyrosyl-tRNA synthetase) (Tyrosyl-tRNA synthetase) (TyrRS)" Aats-tyr-m CG16912 Drosophila melanogaster (Fruit fly) 464 mitochondrial tyrosyl-tRNA aminoacylation [GO:0070184]; tRNA aminoacylation [GO:0043039] GO:0003723; GO:0004831; GO:0005524; GO:0005739; GO:0005759; GO:0005829; GO:0043039; GO:0070184 0 0 0 PF00579; Q9Y4R7 CHOYP_LOC578867.3.5 m.22762 sp TTLL3_HUMAN 47.126 435 218 6 617 1041 179 611 3.93E-128 417 TTLL3_HUMAN reviewed Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) 772 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; protein polyglycylation [GO:0018094] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0035082; GO:0042384; GO:0070735; GO:0070736 0 0 0 PF03133; B3EWY9 CHOYP_contig_010801 m.12476 sp MLP_ACRMI 28.302 1113 640 44 210 1262 353 1367 3.94E-101 362 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O00339 CHOYP_MATN2.1.2 m.1524 sp MATN2_HUMAN 36.538 156 85 4 1 147 656 806 3.94E-25 103 MATN2_HUMAN reviewed Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) 956 axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; response to axon injury [GO:0048678] GO:0001764; GO:0005509; GO:0005578; GO:0005604; GO:0007411; GO:0008347; GO:0031012; GO:0031104; GO:0048678 0 0 0 PF12662;PF07645;PF10393;PF00092; P10155 CHOYP_RO60.5.6 m.54939 sp RO60_HUMAN 38.585 622 289 14 22 641 3 533 3.94E-128 391 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P10280 CHOYP_LOC101384610.1.1 m.41955 sp VKT52_ANESU 61.017 59 23 0 91 149 1 59 3.94E-19 79 VKT52_ANESU reviewed KappaPI-actitoxin-Avd3a (KappaPI-AITX-Avd3a) (Kunitz-type proteinase inhibitor 5 II) (SA5 II) 0 Anemonia sulcata (Mediterranean snakelocks sea anemone) 62 0 GO:0004867; GO:0005576; GO:0042151 0 0 0 PF00014; P21613 CHOYP_KINH.6.9 m.42394 sp KINH_DORPE 68.519 270 66 9 275 538 711 967 3.94E-99 324 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P55906 CHOYP_LOC100533271.1.1 m.24972 sp BGH3_BOVIN 29.052 654 396 16 78 729 45 632 3.94E-74 257 BGH3_BOVIN reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (MP70) (MP78) TGFBI BIGH3 Bos taurus (Bovine) 683 cell adhesion [GO:0007155]; cell proliferation [GO:0008283] GO:0005578; GO:0007155; GO:0008283; GO:0050840 0 0 0 PF02469; P86787 CHOYP_GIGA4.1.3 m.10521 sp GIGA4_CRAGI 100 58 0 0 72 129 1 58 3.94E-38 126 GIGA4_CRAGI reviewed Gigasin-4 (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 58 0 0 0 0 0 0 Q14654 CHOYP_LOC663026.1.1 m.30242 sp KCJ11_HUMAN 36.513 304 180 7 28 327 36 330 3.94E-62 206 KCJ11_HUMAN reviewed "ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11)" KCNJ11 Homo sapiens (Human) 390 cellular response to glucose stimulus [GO:0071333]; cellular response to nicotine [GO:0071316]; cellular response to tumor necrosis factor [GO:0071356]; glucose metabolic process [GO:0006006]; negative regulation of insulin secretion [GO:0046676]; neurological system process [GO:0050877]; positive regulation of cation channel activity [GO:2001259]; potassium ion import [GO:0010107]; potassium ion transmembrane transport [GO:0071805]; regulation of cardiac conduction [GO:1903779]; regulation of insulin secretion [GO:0050796]; regulation of membrane potential [GO:0042391]; response to ATP [GO:0033198]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ischemia [GO:0002931]; response to testosterone [GO:0033574]; transmembrane transport [GO:0055085] GO:0002931; GO:0005249; GO:0005524; GO:0005635; GO:0005739; GO:0005768; GO:0005783; GO:0005829; GO:0005886; GO:0005887; GO:0006006; GO:0008076; GO:0008282; GO:0010107; GO:0014704; GO:0015272; GO:0030315; GO:0030506; GO:0030673; GO:0030955; GO:0032355; GO:0033198; GO:0033574; GO:0042391; GO:0042493; GO:0043025; GO:0043209; GO:0044325; GO:0046676; GO:0050796; GO:0050877; GO:0055085; GO:0070852; GO:0071316; GO:0071333; GO:0071356; GO:0071805; GO:1903779; GO:2001259 0 0 0 PF01007; Q29HY3 CHOYP_CDC42.4.11 m.23717 sp CDC42_DROPS 92.147 191 15 0 1 191 1 191 3.94E-131 368 CDC42_DROPS reviewed Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) 191 maintenance of protein location [GO:0045185]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275; GO:0045185; GO:0045860 0 0 0 PF00071; Q5F371 CHOYP_LOC591290.2.3 m.33516 sp SBNO1_CHICK 53.448 116 52 1 83 198 253 366 3.94E-34 131 SBNO1_CHICK reviewed Protein strawberry notch homolog 1 SBNO1 RCJMB04_30k7 Gallus gallus (Chicken) 1239 "regulation of transcription, DNA-templated [GO:0006355]" GO:0006355 0 0 0 PF13871; Q5SUV2 CHOYP_LOC579832.1.2 m.32173 sp MYBPP_MOUSE 36.23 610 355 12 55 652 12 599 3.94E-108 358 MYBPP_MOUSE reviewed MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1) Mycbpap Amap1 Mus musculus (Mouse) 932 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0007268; GO:0007275; GO:0007283; GO:0016020; GO:0030154 0 0 0 PF14646; Q5ZIJ9 CHOYP_MIB1.2.4 m.35815 sp MIB2_CHICK 44.444 72 33 1 795 859 3 74 3.94E-10 67.8 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6YI48 CHOYP_PTPRT.43.45 m.62159 sp PTPRU_CHICK 32.576 132 82 3 5 129 1112 1243 3.94E-09 56.6 PTPRU_CHICK reviewed Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) (cRPTPPSI) PTPRU RPTPPSI Gallus gallus (Chicken) 1434 cell adhesion [GO:0007155]; cell differentiation [GO:0030154] GO:0004725; GO:0005886; GO:0007155; GO:0016021; GO:0030054; GO:0030154 0 0 cd06263; PF00041;PF00629;PF00102; Q8C9B9 CHOYP_ISCW_ISCW000551.1.1 m.12330 sp DIDO1_MOUSE 51.88 133 62 1 1 131 1066 1198 3.94E-43 159 DIDO1_MOUSE reviewed Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) Dido1 Datf1 Dio1 Mus musculus (Mouse) 2256 "apoptotic signaling pathway [GO:0097190]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0006351; GO:0008270; GO:0044822; GO:0097190 0 0 0 PF00628;PF07744;PF07500; Q8NHV1 CHOYP_LOC101165124.1.2 m.33235 sp GIMA7_HUMAN 40.367 109 65 0 310 418 1 109 3.94E-21 96.3 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q963B6 CHOYP_UBP47.2.2 m.66757 sp RL10A_SPOFR 67.066 167 55 0 2 168 3 169 3.94E-70 214 RL10A_SPOFR reviewed 60S ribosomal protein L10a RpL10A Spodoptera frugiperda (Fall armyworm) 217 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015934 0 0 cd00403; PF00687; Q9D8I5 CHOYP_LOC100771202.1.2 m.45759 sp MF4B2_MOUSE 30.312 320 197 8 5 320 38 335 3.94E-22 99.8 MF4B2_MOUSE reviewed Sodium-dependent glucose transporter 1B (Major facilitator superfamily domain-containing protein 4B2) Mfsd4b2 Naglt1b Mus musculus (Mouse) 366 carbohydrate transport [GO:0008643]; sodium ion transport [GO:0006814] GO:0006814; GO:0008643; GO:0015293; GO:0016021; GO:0016324 0 0 cd06174; PF07690; Q9I7U4 CHOYP_LOC575058.1.1 m.9532 sp TITIN_DROME 37.26 416 242 7 185 597 4394 4793 3.94E-71 268 TITIN_DROME reviewed Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) 18141 cell division [GO:0051301]; locomotion [GO:0040011]; mesoderm development [GO:0007498]; mitotic chromosome condensation [GO:0007076]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; regulation of hemocyte proliferation [GO:0035206]; sarcomere organization [GO:0045214]; sensory perception of pain [GO:0019233]; sister chromatid cohesion [GO:0007062]; skeletal muscle tissue development [GO:0007519]; somatic muscle development [GO:0007525]; visceral muscle development [GO:0007522] GO:0000794; GO:0003779; GO:0005863; GO:0005875; GO:0007062; GO:0007076; GO:0007498; GO:0007517; GO:0007519; GO:0007520; GO:0007522; GO:0007525; GO:0008307; GO:0016203; GO:0019233; GO:0030017; GO:0030018; GO:0031674; GO:0035206; GO:0040011; GO:0045214; GO:0051301 0 0 0 PF06582;PF00041;PF07679;PF00018; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G199235.3.15 m.4763 sp SACS_HUMAN 30.911 757 449 18 40 753 2046 2771 3.94E-85 300 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9P2D7 CHOYP_DNAH12.1.3 m.22375 sp DYH1_HUMAN 70.518 251 74 0 1 251 4080 4330 3.94E-120 380 DYH1_HUMAN reviewed "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)" DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) 4330 cilium movement involved in cell motility [GO:0060294]; cilium or flagellum-dependent cell motility [GO:0001539]; epithelial cilium movement [GO:0003351]; inner dynein arm assembly [GO:0036159]; response to mechanical stimulus [GO:0009612]; sperm motility [GO:0030317] GO:0001539; GO:0003351; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0009612; GO:0016887; GO:0030286; GO:0030317; GO:0036126; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q9QYH9 CHOYP_CARNS1.5.6 m.63617 sp TNF14_MOUSE 29.114 158 99 6 9 163 92 239 3.94E-09 57 TNF14_MOUSE reviewed "Tumor necrosis factor ligand superfamily member 14 (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]" Tnfsf14 Light Mus musculus (Mouse) 239 cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of T cell chemotaxis [GO:0010820]; release of cytoplasmic sequestered NF-kappaB [GO:0008588]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0005102; GO:0005615; GO:0005622; GO:0005886; GO:0006955; GO:0008588; GO:0010820; GO:0016021; GO:0031295; GO:0033209; GO:0043027; GO:0045663; GO:0071260; GO:1901741 0 0 0 PF00229; Q9Y6R7 CHOYP_CYCMA_4408.1.3 m.4675 sp FCGBP_HUMAN 24.342 304 201 10 140 428 59 348 3.94E-14 79.3 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A4IF62 CHOYP_RL5.1.4 m.22293 sp RPC1_BOVIN 58.523 176 70 2 1 176 915 1087 3.95E-59 202 RPC1_BOVIN reviewed DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III subunit A) POLR3A Bos taurus (Bovine) 1390 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003677; GO:0003682; GO:0003899; GO:0005666; GO:0006383; GO:0016020; GO:0032728; GO:0045087; GO:0046872; GO:0051607; GO:1903146; GO:1903955 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998; A4QND0 CHOYP_UBL4A.2.2 m.18059 sp UBL4A_XENTR 38.194 144 75 1 1 144 1 130 3.95E-28 104 UBL4A_XENTR reviewed Ubiquitin-like protein 4A ubl4a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 148 tail-anchored membrane protein insertion into ER membrane [GO:0071816]; transport [GO:0006810] GO:0005829; GO:0006810; GO:0071816; GO:0071818 0 0 0 PF00240; B5X7X4 CHOYP_LTOR2.1.2 m.53702 sp LTOR2_SALSA 77.6 125 28 0 39 163 1 125 3.95E-67 202 LTOR2_SALSA reviewed Ragulator complex protein LAMTOR2 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) lamtor2 Salmo salar (Atlantic salmon) 125 cell growth [GO:0016049]; cellular protein localization [GO:0034613]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008] GO:0005765; GO:0005770; GO:0016049; GO:0032008; GO:0034613; GO:0043547; GO:0071230; GO:0071986 0 0 0 PF03259; D3YXG0 CHOYP_LOC100536583.1.1 m.58016 sp HMCN1_MOUSE 28.272 573 346 25 21 574 641 1167 3.95E-34 146 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O96064 CHOYP_MYSP.4.9 m.2302 sp MYSP_MYTGA 65.217 161 53 2 3 162 7 165 3.95E-62 209 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P10394 CHOYP_DDB_G0294236.1.1 m.12346 sp POL4_DROME 26.667 255 169 7 1 251 995 1235 3.95E-23 105 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P11620 CHOYP_DVIR_GJ12112.3.3 m.57367 sp YPT1_SCHPO 37.288 177 102 6 31 205 9 178 3.95E-26 103 YPT1_SCHPO reviewed GTP-binding protein ypt1 ypt1 SPBC1703.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 203 autophagy [GO:0006914]; negative regulation of G0 to G1 transition [GO:0070317]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0003924; GO:0005525; GO:0005634; GO:0005789; GO:0005829; GO:0006914; GO:0007264; GO:0015031; GO:0034045; GO:0070317 0 0 0 PF00071; P28799 CHOYP_BRAFLDRAFT_102424.1.6 m.901 sp GRN_HUMAN 39.817 545 286 14 125 651 66 586 3.95E-112 354 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P42702 CHOYP_LOC100878272.1.3 m.21183 sp LIFR_HUMAN 21.176 510 321 21 236 715 377 835 3.95E-06 54.7 LIFR_HUMAN reviewed Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) LIFR Homo sapiens (Human) 1097 cell surface receptor signaling pathway [GO:0007166]; ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of muscle cell apoptotic process [GO:0010656]; neuron projection morphogenesis [GO:0048812]; oncostatin-M-mediated signaling pathway [GO:0038165]; organ regeneration [GO:0031100]; positive regulation of cell proliferation [GO:0008284]; response to cytokine [GO:0034097]; response to organic cyclic compound [GO:0014070] GO:0004923; GO:0005127; GO:0005886; GO:0005887; GO:0007166; GO:0008284; GO:0010656; GO:0014070; GO:0019221; GO:0019838; GO:0031100; GO:0034097; GO:0038165; GO:0043235; GO:0048812; GO:0048861; GO:0070062; GO:0070120 0 0 0 PF00041; P70490 CHOYP_BRAFLDRAFT_118602.1.5 m.17411 sp MFGM_RAT 32.941 340 186 13 2320 2640 111 427 3.95E-42 165 MFGM_RAT reviewed Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (O-acetyl GD3 ganglioside synthase) (AGS) (SED1) Mfge8 Ags Rattus norvegicus (Rat) 427 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; positive regulation of cell proliferation [GO:0008284]; response to estrogen [GO:0043627]; single fertilization [GO:0007338] GO:0001525; GO:0005576; GO:0007155; GO:0007338; GO:0008284; GO:0016020; GO:0043627 0 0 0 PF00008;PF00754; Q12955 CHOYP_TVAG_168010.2.45 m.3895 sp ANK3_HUMAN 30.321 343 218 3 712 1054 467 788 3.95E-40 166 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q14202 CHOYP_BRAFLDRAFT_106251.5.6 m.35307 sp ZMYM3_HUMAN 28.309 272 166 10 2 253 969 1231 3.95E-15 82 ZMYM3_HUMAN reviewed Zinc finger MYM-type protein 3 (Zinc finger protein 261) ZMYM3 DXS6673E KIAA0385 ZNF261 Homo sapiens (Human) 1370 cytoskeleton organization [GO:0007010]; multicellular organism development [GO:0007275]; regulation of cell morphogenesis [GO:0022604] GO:0000981; GO:0003677; GO:0005654; GO:0005737; GO:0007010; GO:0007275; GO:0008270; GO:0022604 0 0 0 PF12012;PF06467; Q14624 CHOYP_BRAFLDRAFT_215239.2.3 m.22660 sp ITIH4_HUMAN 37.34 391 195 9 2 370 256 618 3.95E-68 243 ITIH4_HUMAN reviewed Inter-alpha-trypsin inhibitor heavy chain H4 (ITI heavy chain H4) (ITI-HC4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (Gp120) (PK-120) [Cleaved into: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha-trypsin inhibitor heavy chain H4] ITIH4 IHRP ITIHL1 PK120 PRO1851 Homo sapiens (Human) 930 acute-phase response [GO:0006953]; hyaluronan metabolic process [GO:0030212]; platelet degranulation [GO:0002576]; response to cytokine [GO:0034097] GO:0002576; GO:0004866; GO:0004867; GO:0005576; GO:0005886; GO:0006953; GO:0030212; GO:0031089; GO:0034097; GO:0070062; GO:0072562 0 0 0 PF06668;PF08487;PF00092; Q16204 CHOYP_LOC100890071.1.1 m.22590 sp CCDC6_HUMAN 57.54 252 79 8 4 245 194 427 3.95E-72 231 CCDC6_HUMAN reviewed Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) CCDC6 D10S170 TST1 Homo sapiens (Human) 474 0 GO:0005200; GO:0005737; GO:0005856 0 0 0 PF09755; Q6DGQ0 CHOYP_SPT4H.1.1 m.40744 sp SPT4H_DANRE 76.068 117 28 0 1 117 1 117 3.95E-65 195 SPT4H_DANRE reviewed Transcription elongation factor SPT4 (DRB sensitivity-inducing factor small subunit) (DSIF small subunit) supt4h1 zgc:92824 Danio rerio (Zebrafish) (Brachydanio rerio) 117 "positive regulation of DNA-templated transcription, elongation [GO:0032786]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0008270; GO:0032044; GO:0032786 0 0 cd07973; PF06093; Q6PBF0 CHOYP_RL8.7.10 m.41084 sp RL8_XENTR 70 120 36 0 1 120 59 178 3.95E-58 183 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q6PCJ9 CHOYP_PPT2A.1.2 m.30339 sp PPT2A_XENLA 53.008 266 123 2 28 291 30 295 3.95E-101 300 PPT2A_XENLA reviewed Lysosomal thioesterase PPT2-A (PPT-2-A) (EC 3.1.2.-) ppt2-a Xenopus laevis (African clawed frog) 296 0 GO:0005764; GO:0008474 0 0 0 PF02089; Q6UB98 CHOYP_ANR12.1.1 m.66845 sp ANR12_HUMAN 55.122 205 80 4 98 295 130 329 3.95E-61 213 ANR12_HUMAN reviewed Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) 2062 0 GO:0005654; GO:0005737 0 0 0 PF00023;PF12796; Q7Z6B0 CHOYP_LOC754098.1.1 m.43822 sp CCD91_HUMAN 25.726 241 177 2 253 492 199 438 3.95E-07 56.2 CCD91_HUMAN reviewed Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein) CCDC91 GGABP HSD8 Homo sapiens (Human) 441 protein transport [GO:0015031] GO:0005654; GO:0005794; GO:0015031; GO:0016020 0 0 0 0 Q7ZV80 CHOYP_ISCW_ISCW001190.1.1 m.26579 sp SPF30_DANRE 52.34 235 102 4 9 241 3 229 3.95E-77 235 SPF30_DANRE reviewed Survival of motor neuron-related-splicing factor 30 (Survival motor neuron domain-containing protein 1) smndc1 spf30 Danio rerio (Zebrafish) (Brachydanio rerio) 237 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0003723; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0015030; GO:0016607 0 0 0 PF06003; Q8N300 CHOYP_LOC100891071.1.1 m.10940 sp SVBP_HUMAN 53.846 39 18 0 371 409 20 58 3.95E-07 50.4 SVBP_HUMAN reviewed Small vasohibin-binding protein (Coiled coil domain-containing protein 23) SVBP CCDC23 Homo sapiens (Human) 66 negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein ubiquitination [GO:0031397]; protein secretion [GO:0009306] GO:0005576; GO:0009306; GO:0010596; GO:0031397; GO:0045177 0 0 0 PF15674; Q96JM3 CHOYP_contig_043044 m.49679 sp CHAP1_HUMAN 37.719 114 62 1 201 305 249 362 3.95E-08 59.7 CHAP1_HUMAN reviewed Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) CHAMP1 C13orf8 CAMP CHAMP KIAA1802 ZNF828 Homo sapiens (Human) 812 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; protein localization to kinetochore [GO:0034501]; protein localization to microtubule [GO:0035372]; sister chromatid biorientation [GO:0031134] GO:0000777; GO:0000793; GO:0003676; GO:0005634; GO:0005654; GO:0005737; GO:0005819; GO:0031134; GO:0034501; GO:0035372; GO:0046872; GO:0051315 0 0 0 0 Q96Q77 CHOYP_TSP_08109.1.1 m.30848 sp CIB3_HUMAN 54.497 189 84 1 23 211 1 187 3.95E-72 219 CIB3_HUMAN reviewed Calcium and integrin-binding family member 3 (Kinase-interacting protein 3) (KIP 3) CIB3 KIP3 Homo sapiens (Human) 187 0 GO:0000287; GO:0005509 0 0 0 PF13499; Q9ESN6 CHOYP_BRAFLDRAFT_87292.1.6 m.3225 sp TRIM2_MOUSE 25.824 182 120 6 129 304 535 707 3.95E-08 58.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NWH7 CHOYP_SMP_148160.1.1 m.11635 sp SPAT6_HUMAN 35.897 156 95 3 1 153 1 154 3.95E-25 108 SPAT6_HUMAN reviewed Spermatogenesis-associated protein 6 SPATA6 Homo sapiens (Human) 488 cell differentiation [GO:0030154]; motile cilium assembly [GO:0044458]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005576; GO:0007275; GO:0007283; GO:0030154; GO:0044458; GO:0097224 0 0 0 PF14909; Q9P2N7 CHOYP_BRAFLDRAFT_202115.1.1 m.15193 sp KLH13_HUMAN 35.714 574 349 8 39 596 69 638 3.95E-117 365 KLH13_HUMAN reviewed Kelch-like protein 13 (BTB and kelch domain-containing protein 2) KLHL13 BKLHD2 KIAA1309 Homo sapiens (Human) 655 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; A4IF63 CHOYP_BRAFLDRAFT_67264.5.6 m.52713 sp TRIM2_BOVIN 23.973 146 105 3 141 284 602 743 3.96E-07 57 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B4PEU8 CHOYP_RS9.9.13 m.44487 sp RS9_DROYA 87.151 179 23 0 5 183 4 182 3.96E-111 318 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; O14514 CHOYP_CELR2.5.8 m.38389 sp BAI1_HUMAN 25.263 665 409 17 67 688 576 1195 3.96E-57 216 BAI1_HUMAN reviewed Brain-specific angiogenesis inhibitor 1 BAI1 Homo sapiens (Human) 1584 axonogenesis [GO:0007409]; cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell proliferation [GO:0008285]; peripheral nervous system development [GO:0007422]; positive regulation of synapse assembly [GO:0051965]; signal transduction [GO:0007165] GO:0004930; GO:0005886; GO:0005887; GO:0005911; GO:0007155; GO:0007165; GO:0007166; GO:0007186; GO:0007409; GO:0007422; GO:0008285; GO:0014069; GO:0016021; GO:0016525; GO:0051965 0 0 0 PF00002;PF16489;PF01825;PF02793;PF00090; O83041 CHOYP_CAOG_02976.1.2 m.41292 sp PIP_LEPBY 62.5 312 117 0 5 316 1 312 3.96E-146 417 PIP_LEPBY reviewed Probable proline iminopeptidase (PIP) (EC 3.4.11.5) (Prolyl aminopeptidase) (PAP) pip Leptolyngbya boryana (Plectonema boryanum) 321 0 GO:0004177; GO:0005737 0 0 0 PF00561; P0DKR2 CHOYP_C5H3ORF23.1.1 m.24213 sp TCAIM_RAT 30.827 266 150 7 5 248 11 264 3.96E-29 117 TCAIM_RAT reviewed "T-cell activation inhibitor, mitochondrial (Tolerance-associated gene-1) (TOAG-1)" Tcaim Toag1 Rattus norvegicus (Rat) 505 0 GO:0005739 0 0 0 PF14687;PF14688; P22488 CHOYP_BRAFLDRAFT_282105.2.2 m.59783 sp IFEA_HELAS 36.438 365 223 4 12 374 213 570 3.96E-70 233 IFEA_HELAS reviewed Non-neuronal cytoplasmic intermediate filament protein (IF) 0 Helix aspersa (Brown garden snail) (Cornu aspersum) 576 0 GO:0005198; GO:0005737; GO:0005882 0 0 0 PF00038; P34826 CHOYP_EEF1B2.1.1 m.5876 sp EF1B_RABIT 69.512 82 25 0 24 105 1 82 3.96E-33 117 EF1B_RABIT reviewed Elongation factor 1-beta (EF-1-beta) EEF1B EF1B Oryctolagus cuniculus (Rabbit) 225 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P54277 CHOYP_PMS1.2.3 m.40339 sp PMS1_HUMAN 64.458 166 59 0 7 172 1 166 3.96E-62 219 PMS1_HUMAN reviewed PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) PMS1 PMSL1 Homo sapiens (Human) 932 mismatch repair [GO:0006298] GO:0000795; GO:0003677; GO:0003697; GO:0005524; GO:0005634; GO:0005712; GO:0006298; GO:0016887; GO:0030983; GO:0032389 0 0 0 PF01119;PF00505; P86952 CHOYP_TYRO2.3.5 m.41485 sp TYRO_PINMA 37.89 417 216 15 4 393 9 409 3.96E-68 236 TYRO_PINMA reviewed Tyrosinase-like protein (Tyrosinase-2) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 456 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; P91875 CHOYP_RPA1.1.2 m.3321 sp RPA1_DROME 56.481 108 47 0 2 109 1534 1641 3.96E-36 132 RPA1_DROME reviewed DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) RpI1 RPA1 CG10122 Drosophila melanogaster (Fruit fly) 1642 transcription from RNA polymerase I promoter [GO:0006360] GO:0003677; GO:0003899; GO:0005736; GO:0006360; GO:0008270 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998; P98158 CHOYP_SORL.1.3 m.4531 sp LRP2_RAT 40.647 278 143 8 36 293 2836 3111 3.96E-40 162 LRP2_RAT reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) 4660 aging [GO:0007568]; endosomal transport [GO:0016197]; hemoglobin import [GO:0020028]; hormone secretion [GO:0046879]; lipoprotein transport [GO:0042953]; negative regulation of endopeptidase activity [GO:0010951]; organ regeneration [GO:0031100]; receptor-mediated endocytosis [GO:0006898]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; transcytosis [GO:0045056]; vitamin metabolic process [GO:0006766] GO:0004872; GO:0005509; GO:0005615; GO:0005737; GO:0005768; GO:0005903; GO:0005905; GO:0006766; GO:0006898; GO:0007568; GO:0010165; GO:0010951; GO:0016020; GO:0016021; GO:0016197; GO:0016324; GO:0020028; GO:0030165; GO:0030492; GO:0031100; GO:0031526; GO:0032403; GO:0032526; GO:0033280; GO:0042493; GO:0042562; GO:0042953; GO:0043234; GO:0045056; GO:0045121; GO:0046879; GO:0050750 0 0 0 PF12662;PF07645;PF00057;PF00058; Q02543 CHOYP_RL18A.3.8 m.22787 sp RL18A_HUMAN 70.625 160 47 0 2 161 17 176 3.96E-83 245 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q07113 CHOYP_MPRI.1.1 m.30683 sp MPRI_MOUSE 33.333 123 70 5 17 136 497 610 3.96E-10 59.7 MPRI_MOUSE reviewed Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222) Igf2r Mus musculus (Mouse) 2483 liver development [GO:0001889]; organ regeneration [GO:0031100]; positive regulation of apoptotic process [GO:0043065]; post-embryonic development [GO:0009791]; response to retinoic acid [GO:0032526]; spermatogenesis [GO:0007283] GO:0001889; GO:0001948; GO:0001972; GO:0004930; GO:0005215; GO:0005520; GO:0005537; GO:0005615; GO:0005634; GO:0005641; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005802; GO:0005886; GO:0005925; GO:0007283; GO:0009791; GO:0009986; GO:0016020; GO:0016021; GO:0030118; GO:0030139; GO:0030140; GO:0031100; GO:0032526; GO:0042802; GO:0043065; GO:0048471; GO:0051219; GO:0070062 0 0 cd00062; PF00878;PF00040; Q09575 CHOYP_contig_001932 m.2147 sp YRD6_CAEEL 26.023 342 218 13 51 377 241 562 3.96E-20 95.9 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q14590 CHOYP_ZN813.1.1 m.35782 sp ZN235_HUMAN 34.746 354 175 10 376 726 321 621 3.96E-54 203 ZN235_HUMAN reviewed Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) 738 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q53G44 CHOYP_SI_CH211-197G15.7.1.3 m.4409 sp IF44L_HUMAN 32.36 445 252 11 25 455 26 435 3.96E-54 191 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5RFI5 CHOYP_LOC100184076.1.1 m.8037 sp FUCO2_PONAB 55.319 94 41 1 32 124 32 125 3.96E-34 125 FUCO2_PONAB reviewed Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 465 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; Q5ZKX1 CHOYP_TRIADDRAFT_25769.1.1 m.25945 sp CHM1B_CHICK 69.744 195 58 1 2 196 3 196 3.96E-82 245 CHM1B_CHICK reviewed Charged multivesicular body protein 1b (Chromatin-modifying protein 1b) (CHMP1b) CHMP1B RCJMB04_8n10 Gallus gallus (Chicken) 199 protein transport [GO:0015031]; vacuolar transport [GO:0007034] GO:0005829; GO:0007034; GO:0015031; GO:0031902 0 0 0 PF03357; Q63638 CHOYP_LOC660533.1.1 m.19439 sp SPEG_RAT 24.409 508 327 12 3 510 710 1160 3.96E-31 135 SPEG_RAT reviewed Striated muscle-specific serine/threonine-protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) Speg Apeg1 Rattus norvegicus (Rat) 3259 muscle cell differentiation [GO:0042692] GO:0004674; GO:0005524; GO:0005634; GO:0042692 0 0 0 PF07679;PF00069; Q659A1 CHOYP_NARG2.1.1 m.5 sp ICE2_HUMAN 32.275 189 122 4 1145 1331 769 953 3.96E-24 114 ICE2_HUMAN reviewed Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) ICE2 BRCC1 NARG2 UNQ3101/PRO10100 Homo sapiens (Human) 982 positive regulation of transcription from RNA polymerase III promoter [GO:0045945]; snRNA transcription from RNA polymerase III promoter [GO:0042796]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0005654; GO:0008023; GO:0015030; GO:0035327; GO:0035363; GO:0042795; GO:0042796; GO:0045945 0 0 0 PF10505; Q6R7G0 CHOYP_Y068.5.6 m.33535 sp Y068_OSHVF 22.943 632 413 19 349 911 5 631 3.96E-34 144 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q7ZXX1 CHOYP_CEAM5.5.6 m.63392 sp CADM3_XENLA 26.124 356 220 11 160 514 67 380 3.96E-12 71.6 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q80V70 CHOYP_LOC100907349.2.3 m.33999 sp MEGF6_MOUSE 29.31 232 135 11 2 207 1077 1305 3.96E-11 68.6 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8BLH7 CHOYP_LOC100378607.1.2 m.17330 sp HIRP3_MOUSE 30 150 84 3 659 793 455 598 3.96E-08 60.5 HIRP3_MOUSE reviewed HIRA-interacting protein 3 Hirip3 Mus musculus (Mouse) 601 0 GO:0005634; GO:0005730 0 0 0 PF09649; Q8N695 CHOYP_LOC100313639.3.3 m.60798 sp SC5A8_HUMAN 34.305 583 357 15 5 572 8 579 3.96E-90 293 SC5A8_HUMAN reviewed Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) 610 apoptotic process [GO:0006915]; ion transport [GO:0006811]; sodium ion transport [GO:0006814] GO:0005886; GO:0005887; GO:0006811; GO:0006814; GO:0006915; GO:0008028; GO:0015293; GO:0016324; GO:0022803; GO:0070062 0 0 0 PF00474; Q9BZE2 CHOYP_BRAFLDRAFT_110975.1.1 m.23199 sp PUS3_HUMAN 53.226 186 79 2 30 210 12 194 3.96E-60 198 PUS3_HUMAN reviewed tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3) PUS3 FKSG32 Homo sapiens (Human) 481 tRNA pseudouridine synthesis [GO:0031119] GO:0003723; GO:0005634; GO:0009982; GO:0031119 0 0 0 PF01416; Q9D4J7 CHOYP_LOC100491301.1.2 m.48113 sp PHF6_MOUSE 40.506 79 36 2 37 115 61 128 3.96E-10 66.2 PHF6_MOUSE reviewed PHD finger protein 6 Phf6 Kiaa1823 Mus musculus (Mouse) 364 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000777; GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0008270; GO:0015631; GO:0019899; GO:0042393; GO:0042826; GO:0043021; GO:0044822; GO:0051219; GO:0097110 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_79377.8.30 m.32602 sp TRIM2_MOUSE 27.027 222 137 8 179 389 536 743 3.96E-08 58.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_206799.17.23 m.46288 sp TRIM2_BOVIN 25 140 101 3 429 565 605 743 3.97E-06 53.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_DWIL_GK23042.1.1 m.38797 sp CRNS1_HUMAN 36.975 119 68 2 10 121 336 454 3.97E-16 76.6 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A8E657 CHOYP_LOC100906268.2.2 m.44952 sp AASS_BOVIN 47.059 153 81 0 9 161 761 913 3.97E-39 143 AASS_BOVIN reviewed "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Bos taurus (Bovine) 926 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512] GO:0005739; GO:0033512; GO:0047130; GO:0047131 PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.; PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. 0 0 PF05222;PF16653;PF03435; E1BD59 CHOYP_BBOV_II003210.12.13 m.64655 sp TRI56_BOVIN 29.204 113 63 4 55 150 101 213 3.97E-06 49.7 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O15018 CHOYP_LOC100370705.2.2 m.55449 sp PDZD2_HUMAN 47.5 80 42 0 2207 2286 2755 2834 3.97E-16 89.4 PDZD2_HUMAN reviewed PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] PDZD2 AIPC KIAA0300 PDZK3 Homo sapiens (Human) 2839 cell adhesion [GO:0007155] GO:0005576; GO:0005634; GO:0005737; GO:0005783; GO:0005911; GO:0007155 0 0 0 PF00595; O96790 CHOYP_SETD3.1.1 m.42583 sp DPGN_DIPMA 28.293 205 106 7 13 176 62 266 3.97E-08 56.6 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P18091 CHOYP_ACTN.2.2 m.63975 sp ACTN_DROME 92.857 210 15 0 7 216 13 222 3.97E-131 394 ACTN_DROME reviewed "Alpha-actinin, sarcomeric (F-actin cross-linking protein)" Actn fliA l(1)2Cb CG4376 Drosophila melanogaster (Fruit fly) 924 actin cytoskeleton reorganization [GO:0031532]; cytoskeletal anchoring at plasma membrane [GO:0007016]; flight behavior [GO:0007629]; sarcomere organization [GO:0045214] GO:0003779; GO:0005509; GO:0005925; GO:0007016; GO:0007629; GO:0030018; GO:0031532; GO:0045214 0 0 0 PF00307;PF13405;PF08726;PF00435; P40983 CHOYP_BRAFLDRAFT_89869.3.3 m.37644 sp YOR6_CALSR 26.757 370 202 17 144 491 35 357 3.97E-07 56.2 YOR6_CALSR reviewed Uncharacterized protein in xynA 3'region (ORF6) (Fragment) 0 Caldicellulosiruptor sp. (strain Rt8B.4) 402 0 0 0 0 0 PF00350; P42325 CHOYP_BRAFLDRAFT_116053.1.1 m.63017 sp NCAH_DROME 50.543 184 90 1 37 219 1 184 3.97E-67 208 NCAH_DROME reviewed Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) 190 0 GO:0005509 0 0 0 PF00036;PF13499; P50430 CHOYP_BRAFLDRAFT_206907.8.11 m.46927 sp ARSB_RAT 50 296 138 1 20 305 32 327 3.97E-101 309 ARSB_RAT reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb Rattus norvegicus (Rat) 528 autophagy [GO:0006914]; central nervous system development [GO:0007417]; colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005791; GO:0005794; GO:0006914; GO:0007417; GO:0007584; GO:0008152; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0043627; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; P60815 CHOYP_BRAFLDRAFT_231234.1.1 m.37739 sp FLVC2_RAT 53.363 446 197 3 32 474 79 516 3.97E-165 481 FLVC2_RAT reviewed Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT) Flvcr2 Rattus norvegicus (Rat) 546 transmembrane transport [GO:0055085] GO:0005886; GO:0015232; GO:0016021; GO:0020037; GO:0055085 0 0 cd06174; PF07690; Q04999 CHOYP_DWIL_GK13592.1.1 m.19641 sp INHBB_MOUSE 31.2 125 77 3 229 352 295 411 3.97E-07 55.1 INHBB_MOUSE reviewed Inhibin beta B chain (Activin beta-B chain) Inhbb Mus musculus (Mouse) 411 activin receptor signaling pathway [GO:0032924]; cellular response to insulin stimulus [GO:0032869]; cellular response to leptin stimulus [GO:0044320]; cellular response to starvation [GO:0009267]; eye development [GO:0001654]; fat cell differentiation [GO:0045444]; growth [GO:0040007]; negative regulation of follicle-stimulating hormone secretion [GO:0046882]; negative regulation of hepatocyte growth factor biosynthetic process [GO:0048178]; negative regulation of insulin secretion [GO:0046676]; oocyte development [GO:0048599]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of ovulation [GO:0060279]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; regulation of MAPK cascade [GO:0043408]; response to mechanical stimulus [GO:0009612]; SMAD protein signal transduction [GO:0060395] GO:0001654; GO:0005125; GO:0005160; GO:0005576; GO:0005615; GO:0009267; GO:0009612; GO:0010862; GO:0032869; GO:0032924; GO:0040007; GO:0042803; GO:0043408; GO:0044320; GO:0045444; GO:0046676; GO:0046881; GO:0046882; GO:0048178; GO:0048471; GO:0048599; GO:0060279; GO:0060395; GO:0071944; GO:2001235 0 0 0 PF00019;PF00688; Q07243 CHOYP_LOC100693092.1.1 m.45278 sp MTF1_MOUSE 55.049 307 118 5 70 358 92 396 3.97E-109 348 MTF1_MOUSE reviewed Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1) Mtf1 Mtf-1 Mus musculus (Mouse) 675 "positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]" GO:0000978; GO:0000979; GO:0001047; GO:0001077; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0006979; GO:0035035; GO:0045893; GO:0045944; GO:0046686; GO:0046872 0 0 0 0 Q0VCJ7 CHOYP_RERG.2.2 m.66162 sp RERG_BOVIN 64.398 191 67 1 15 204 4 194 3.97E-89 263 RERG_BOVIN reviewed Ras-related and estrogen-regulated growth inhibitor RERG Bos taurus (Bovine) 199 negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0005829; GO:0007264; GO:0008285; GO:0009725; GO:0016020; GO:0030308 0 0 0 PF00071; Q28CB1 CHOYP_LOC101174263.1.1 m.43920 sp TBD2B_XENTR 42.249 587 320 8 18 602 370 939 3.97E-148 454 TBD2B_XENTR reviewed TBC1 domain family member 2B tbc1d2b TGas126k13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 943 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF00169;PF00566; Q2KIK3 CHOYP_SMIM14.1.3 m.981 sp SIM14_BOVIN 54.167 96 37 3 4 95 5 97 3.97E-28 100 SIM14_BOVIN reviewed Small integral membrane protein 14 SMIM14 Bos taurus (Bovine) 99 0 GO:0005783; GO:0005789; GO:0016021 0 0 0 PF11027; Q2KIK3 CHOYP_SMIM14.3.3 m.61912 sp SIM14_BOVIN 54.167 96 37 3 4 95 5 97 3.97E-28 100 SIM14_BOVIN reviewed Small integral membrane protein 14 SMIM14 Bos taurus (Bovine) 99 0 GO:0005783; GO:0005789; GO:0016021 0 0 0 PF11027; Q3SZH7 CHOYP_LKHA4.2.2 m.40033 sp LKHA4_BOVIN 56.724 409 176 1 1 409 171 578 3.97E-174 502 LKHA4_BOVIN reviewed Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H Bos taurus (Bovine) 611 leukotriene biosynthetic process [GO:0019370]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004177; GO:0004301; GO:0004463; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0019370; GO:0042277; GO:0043171; GO:0044822; GO:0070006; GO:0070062 PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. 0 0 PF09127;PF01433; Q5UQ50 CHOYP_BRAFLDRAFT_276908.1.1 m.28794 sp COLL6_MIMIV 39.446 289 135 14 217 465 467 755 3.97E-11 69.7 COLL6_MIMIV reviewed Collagen-like protein 6 MIMI_L668 Acanthamoeba polyphaga mimivirus (APMV) 1387 0 GO:0019012 0 0 0 PF01391; Q60438 CHOYP_LOC100697247.1.2 m.37588 sp CREL2_CRIGR 46.825 126 63 3 1 124 206 329 3.97E-28 109 CREL2_CRIGR reviewed Cysteine-rich with EGF-like domain protein 2 (Protein HT) CRELD2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 348 0 GO:0005509; GO:0005576; GO:0005783 0 0 0 PF11938;PF07645; Q6DIB5 CHOYP_MEGF6.11.59 m.24279 sp MEG10_MOUSE 35.799 676 345 30 141 759 182 825 3.97E-79 279 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6PBF0 CHOYP_RL8.6.10 m.38924 sp RL8_XENTR 80.571 175 34 0 1 175 82 256 3.97E-101 294 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q7L4E1 CHOYP_AAEL_AAEL006016.1.1 m.7182 sp MIGA2_HUMAN 40.959 459 229 7 79 498 107 562 3.97E-105 329 MIGA2_HUMAN reviewed Mitoguardin-2 (Protein FAM73B) FAM73B C9orf54 MIGA2 PSEC0112 Homo sapiens (Human) 593 bone development [GO:0060348]; mitochondrial fusion [GO:0008053] GO:0005741; GO:0008053; GO:0042803; GO:0045203; GO:0046982; GO:0060348 0 0 0 PF10265; Q7M456 CHOYP_RNOY.2.3 m.6032 sp RNOY_CRAGI 53.846 195 83 4 47 238 2 192 3.97E-72 223 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q8AV57 CHOYP_LOC100491367.3.3 m.44590 sp SDK2_CHICK 27.103 214 116 5 40 249 1245 1422 3.97E-13 72 SDK2_CHICK reviewed Protein sidekick-2 SDK2 Gallus gallus (Chicken) 2177 camera-type eye photoreceptor cell differentiation [GO:0060219]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; retina layer formation [GO:0010842]; synapse assembly [GO:0007416] GO:0005886; GO:0007156; GO:0007416; GO:0010842; GO:0016021; GO:0030054; GO:0042802; GO:0045202; GO:0060219 0 0 0 PF00041;PF07679; Q8HZ57 CHOYP_CCHCR1.1.1 m.59141 sp CCHCR_PANPA 29.705 542 346 11 156 686 178 695 3.97E-43 171 CCHCR_PANPA reviewed Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) CCHCR1 HCR Pan paniscus (Pygmy chimpanzee) (Bonobo) 782 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005634; GO:0005814; GO:0007275; GO:0030154 0 0 0 PF07111; Q8NDA2 CHOYP_CHL1.2.2 m.65829 sp HMCN2_HUMAN 25.326 383 240 16 237 609 640 986 3.97E-09 64.7 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q922M5 CHOYP_BRAFLDRAFT_126227.1.1 m.24341 sp CDA7L_MOUSE 39.015 264 126 5 4 263 205 437 3.97E-58 194 CDA7L_MOUSE reviewed Cell division cycle-associated 7-like protein (Transcription factor RAM2) Cdca7l Mus musculus (Mouse) 438 "positive regulation of cell proliferation [GO:0008284]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0008284 0 0 0 PF10497; Q95K40 CHOYP_LOC584368.2.2 m.53495 sp CCD83_MACFA 29.947 374 251 3 1 374 22 384 3.97E-42 155 CCD83_MACFA reviewed Coiled-coil domain-containing protein 83 CCDC83 QtsA-10152 QtsA-19320 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 413 0 0 0 0 0 0 Q98943 CHOYP_LOC100700134.1.1 m.66912 sp CASP2_CHICK 29.577 142 86 2 84 225 3 130 3.97E-08 57.4 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q99JW2 CHOYP_BRAFLDRAFT_262219.1.2 m.50377 sp ACY1_MOUSE 67.722 158 50 1 1 158 63 219 3.97E-73 229 ACY1_MOUSE reviewed Aminoacylase-1 (ACY-1) (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) Acy1 Mus musculus (Mouse) 408 cellular amino acid metabolic process [GO:0006520]; peptide catabolic process [GO:0043171] GO:0004046; GO:0005737; GO:0006520; GO:0008270; GO:0043171; GO:0070062; GO:0070573 0 0 cd05646; PF07687;PF01546; Q9CZJ2 CHOYP_BRAFLDRAFT_208197.16.21 m.55399 sp HS12B_MOUSE 34.146 369 189 10 11 326 61 428 3.97E-54 191 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9Y493 CHOYP_BRAFLDRAFT_234265.1.1 m.12091 sp ZAN_HUMAN 48.276 87 43 1 366 450 556 642 3.97E-07 56.6 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A8WQK3 CHOYP_LOC756795.1.1 m.21336 sp ACH1_CAEBR 30.746 335 229 2 37 370 14 346 3.98E-59 205 ACH1_CAEBR reviewed Acetylcholine receptor subunit alpha-type acr-16 acr-16 CBG01491 Caenorhabditis briggsae 499 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; O75382 CHOYP_contig_050802 m.60523 sp TRIM3_HUMAN 23.105 277 164 13 36 283 486 742 3.98E-07 54.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P29314 CHOYP_RS9.6.13 m.40462 sp RS9_RAT 90.395 177 13 1 39 211 1 177 3.98E-111 319 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P48317 CHOYP_GADD45AB.1.1 m.56478 sp GA45A_RAT 38.679 106 59 3 34 133 25 130 3.98E-11 61.6 GA45A_RAT reviewed Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1) Gadd45a Ddit1 Gadd45 Rattus norvegicus (Rat) 165 cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; G2/M transition of mitotic cell cycle [GO:0000086] GO:0000086; GO:0005634; GO:0006974; GO:0007050 0 0 0 PF01248; P49446 CHOYP_contig_032916 m.37612 sp PTPRE_MOUSE 33.157 567 354 12 1730 2282 134 689 3.98E-96 331 PTPRE_MOUSE reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) Ptpre Ptpe Mus musculus (Mouse) 699 negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0004725; GO:0005634; GO:0005737; GO:0005886; GO:0007185; GO:0016021; GO:0033003; GO:0042803; GO:0046627 0 0 0 PF00102; Q01240 CHOYP_LIS1.1.1 m.56214 sp NF60_DORPE 48.235 85 44 0 13 97 100 184 3.98E-17 78.6 NF60_DORPE reviewed 60 kDa neurofilament protein (NF60) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 511 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q2KI24 CHOYP_MTHSD.2.2 m.46742 sp MTHSD_BOVIN 62.151 251 95 0 23 273 7 257 3.98E-115 343 MTHSD_BOVIN reviewed Methenyltetrahydrofolate synthase domain-containing protein MTHFSD Bos taurus (Bovine) 380 0 GO:0000166; GO:0044822 0 0 0 PF01812;PF00076; Q3B7G7 CHOYP_BRAFLDRAFT_117401.3.3 m.42516 sp SR1IP_DANRE 66.667 36 12 0 10 45 9 44 3.98E-14 69.7 SR1IP_DANRE reviewed Protein SREK1IP1 srek1ip1 sfrs12ip1 zgc:123019 Danio rerio (Zebrafish) (Brachydanio rerio) 158 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0003676; GO:0006397; GO:0008270; GO:0008380 0 0 0 0 Q3KQF4 CHOYP_LOC100378486.1.1 m.7121 sp LRC69_XENLA 47.23 343 181 0 1 343 1 343 3.98E-99 299 LRC69_XENLA reviewed Leucine-rich repeat-containing protein 69 lrrc69 Xenopus laevis (African clawed frog) 345 0 0 0 0 0 PF13855; Q5E9E1 CHOYP_PDLI1.1.2 m.1243 sp PDLI1_BOVIN 35.882 340 156 8 11 313 3 317 3.98E-54 182 PDLI1_BOVIN reviewed PDZ and LIM domain protein 1 (Elfin) PDLIM1 Bos taurus (Bovine) 328 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003713; GO:0005667; GO:0005737; GO:0005856; GO:0006355; GO:0008270 0 0 0 PF15936;PF00412;PF00595; Q5FVR1 CHOYP_ZDHHC4.1.1 m.18453 sp ZDHC4_RAT 30.303 363 232 6 1 362 1 343 3.98E-45 160 ZDHC4_RAT reviewed Probable palmitoyltransferase ZDHHC4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) (DHHC-4) Zdhhc4 Rattus norvegicus (Rat) 343 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q5R6J7 CHOYP_GPAT4.1.1 m.56178 sp GPAT4_PONAB 52.632 437 181 5 25 456 31 446 3.98E-158 458 GPAT4_PONAB reviewed Glycerol-3-phosphate acyltransferase 4 (GPAT4) (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta) GPAT4 AGPAT6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 456 acyl-CoA metabolic process [GO:0006637]; CDP-diacylglycerol biosynthetic process [GO:0016024]; diacylglycerol metabolic process [GO:0046339]; fatty acid metabolic process [GO:0006631]; glandular epithelial cell maturation [GO:0002071]; lactation [GO:0007595]; lipid biosynthetic process [GO:0008610]; phosphatidylcholine biosynthetic process [GO:0006656]; regulation of multicellular organism growth [GO:0040014]; triglyceride biosynthetic process [GO:0019432] GO:0002071; GO:0004366; GO:0005783; GO:0005789; GO:0006631; GO:0006637; GO:0006656; GO:0007595; GO:0008610; GO:0016021; GO:0016024; GO:0019432; GO:0040014; GO:0046339 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. 0 0 PF01553; Q5R8Z8 CHOYP_LOC762871.1.1 m.37896 sp RAB14_PONAB 88.785 214 17 1 1 214 1 207 3.98E-141 395 RAB14_PONAB reviewed Ras-related protein Rab-14 RAB14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 215 defense response to bacterium [GO:0042742]; embryo development [GO:0009790]; endocytic recycling [GO:0032456]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; phagosome maturation [GO:0090382]; protein transport [GO:0015031]; regulation of protein localization [GO:0032880]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0003924; GO:0005525; GO:0005802; GO:0005829; GO:0006895; GO:0007264; GO:0008543; GO:0009790; GO:0015031; GO:0019003; GO:0031901; GO:0032456; GO:0032880; GO:0042742; GO:0045335; GO:0055037; GO:0090382 0 0 0 PF00071; Q5U239 CHOYP_TM145.1.2 m.8634 sp TM145_XENLA 37.473 467 278 4 24 484 17 475 3.98E-105 330 TM145_XENLA reviewed Transmembrane protein 145 tmem145 Xenopus laevis (African clawed frog) 547 G-protein coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] GO:0007186; GO:0016021; GO:0019236 0 0 0 PF10192; Q5U305 CHOYP_KDELR2.1.1 m.7397 sp ERD22_RAT 84 150 24 0 1 150 63 212 3.98E-91 266 ERD22_RAT reviewed ER lumen protein-retaining receptor 2 (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) Kdelr2 Rattus norvegicus (Rat) 212 protein retention in ER lumen [GO:0006621]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005789; GO:0005801; GO:0006621; GO:0015031; GO:0016021; GO:0016192; GO:0046923; GO:0070062 0 0 0 PF00810; Q60431 CHOYP_LOC101242711.1.1 m.12485 sp CASP3_MESAU 34.921 126 61 3 1 126 61 165 3.98E-12 69.7 CASP3_MESAU reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q68DL7 CHOYP_LOC100006059.1.1 m.48159 sp CR063_HUMAN 39.159 309 184 3 18 324 15 321 3.98E-64 229 CR063_HUMAN reviewed Uncharacterized protein C18orf63 C18orf63 Homo sapiens (Human) 685 0 0 0 0 0 PF15813; Q6P1J6 CHOYP_LOC101164444.1.1 m.42364 sp PLB1_HUMAN 48.182 330 155 8 120 437 382 707 3.98E-90 304 PLB1_HUMAN reviewed "Phospholipase B1, membrane-associated (Phospholipase B) (hPLB) (Phospholipase B/lipase) (PLB/LIP) [Includes: Phospholipase A2 (EC 3.1.1.4); Lysophospholipase (EC 3.1.1.5)]" PLB1 PLB Homo sapiens (Human) 1458 lipid catabolic process [GO:0016042]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; positive regulation of acrosome reaction [GO:2000344]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0004622; GO:0004623; GO:0005886; GO:0016021; GO:0016042; GO:0016324; GO:0036151; GO:0050253; GO:2000344 0 0 0 PF00657; Q6P2X9 CHOYP_MOT14.1.1 m.42495 sp MOT12_XENTR 28.64 419 270 6 19 412 14 428 3.98E-51 184 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q8CHL0 CHOYP_LOC101175347.1.1 m.40716 sp FZD5_RAT 38.679 106 63 2 53 158 33 136 3.98E-19 90.9 FZD5_RAT reviewed Frizzled-5 (Fz-5) Fzd5 Rattus norvegicus (Rat) 585 canonical Wnt signaling pathway [GO:0060070]; multicellular organism development [GO:0007275]; non-canonical Wnt signaling pathway [GO:0035567] GO:0000139; GO:0004930; GO:0005886; GO:0007275; GO:0016021; GO:0017147; GO:0035567; GO:0042813; GO:0060070 0 0 0 PF01534;PF01392; Q8W485 CHOYP_LOC101163250.1.3 m.12394 sp Y5010_ARATH 39.535 86 52 0 25 110 103 188 3.98E-15 71.2 Y5010_ARATH reviewed "Uncharacterized protein At5g50100, mitochondrial" At5g50100 MPF21.11 Arabidopsis thaliana (Mouse-ear cress) 214 0 GO:0005739 0 0 0 PF04134; Q920B6 CHOYP_KCNK2.2.2 m.52375 sp KCNK2_RAT 40.167 239 132 5 1 231 57 292 3.98E-45 158 KCNK2_RAT reviewed Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Stretch-activated potassium channel TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1) Kcnk2 Trek Rattus norvegicus (Rat) 426 cardiac ventricle development [GO:0003231]; cellular response to hypoxia [GO:0071456]; cochlea development [GO:0090102]; G-protein coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of cell death [GO:0010942]; positive regulation of cellular response to hypoxia [GO:1900039]; potassium ion transmembrane transport [GO:0071805]; response to axon injury [GO:0048678]; response to mechanical stimulus [GO:0009612]; stabilization of membrane potential [GO:0030322] GO:0003231; GO:0005634; GO:0005783; GO:0005789; GO:0005886; GO:0005887; GO:0007186; GO:0007613; GO:0008076; GO:0009612; GO:0009986; GO:0010942; GO:0015271; GO:0016324; GO:0019870; GO:0022841; GO:0030322; GO:0030424; GO:0043005; GO:0043025; GO:0043679; GO:0044305; GO:0048678; GO:0060044; GO:0071456; GO:0071805; GO:0090102; GO:0097449; GO:1900039; GO:2000279 0 0 0 PF07885; Q95LI2 CHOYP_VWA2.2.3 m.21458 sp VITRN_BOVIN 28.058 139 93 2 58 193 244 378 3.98E-11 65.1 VITRN_BOVIN reviewed Vitrin VIT Bos taurus (Bovine) 652 0 GO:0005578 0 0 0 PF03815;PF00092; Q96DP5 CHOYP_MTFMT.1.1 m.16949 sp FMT_HUMAN 42.899 345 175 7 86 420 18 350 3.98E-83 264 FMT_HUMAN reviewed "Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)" MTFMT FMT FMT1 Homo sapiens (Human) 389 0 GO:0004479; GO:0005739 0 0 0 PF02911;PF00551; Q96RW7 CHOYP_HMCN1.32.44 m.58935 sp HMCN1_HUMAN 26.011 1607 939 65 64 1591 571 2006 3.98E-98 358 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99816 CHOYP_TS101.1.4 m.38307 sp TS101_HUMAN 52.941 170 73 2 1 166 1 167 3.98E-63 204 TS101_HUMAN reviewed Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) TSG101 Homo sapiens (Human) 390 "autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; cell cycle arrest [GO:0007050]; cell division [GO:0051301]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; intracellular transport of virus [GO:0075733]; keratinocyte differentiation [GO:0030216]; multivesicular body assembly [GO:0036258]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein monoubiquitination [GO:0006513]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]" GO:0000813; GO:0001558; GO:0003677; GO:0003714; GO:0005730; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005771; GO:0005886; GO:0006513; GO:0006914; GO:0007050; GO:0008285; GO:0008333; GO:0010008; GO:0015031; GO:0016197; GO:0019058; GO:0030216; GO:0030374; GO:0031625; GO:0031902; GO:0036258; GO:0039702; GO:0042803; GO:0043130; GO:0043162; GO:0043405; GO:0045892; GO:0046755; GO:0046790; GO:0048306; GO:0048524; GO:0051301; GO:0070062; GO:0075733; GO:0097352; GO:1902188; GO:1903543; GO:1903551; GO:1903772; GO:1903774; GO:2000397 0 0 0 PF05743;PF09454; Q9BDB7 CHOYP_SI_CH211-197G15.10.2.7 m.11622 sp IF44L_MOUSE 50.877 114 53 2 24 135 180 292 3.98E-26 104 IF44L_MOUSE reviewed Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) 447 immune response [GO:0006955] GO:0005654; GO:0005737; GO:0006955 0 0 0 0 Q9ESN6 CHOYP_TRIM3.47.58 m.47087 sp TRIM2_MOUSE 26.244 221 145 7 28 242 523 731 3.98E-10 63.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9PTJ6 CHOYP_LOC100141993.1.1 m.52102 sp CTDSL_CHICK 64.539 282 76 4 1 265 1 275 3.98E-124 357 CTDSL_CHICK reviewed CTD small phosphatase-like protein (CTDSP-like) (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 1) (NLI-interacting factor 1) (Small C-terminal domain phosphatase 3) NFI1 NIF Gallus gallus (Chicken) 275 0 GO:0004721; GO:0005634; GO:0046872 0 0 0 PF03031; Q9TU23 CHOYP_NEMVEDRAFT_V1G246279.1.1 m.17003 sp CE290_BOVIN 48.387 62 32 0 179 240 1387 1448 3.98E-07 54.3 CE290_BOVIN reviewed Centrosomal protein of 290 kDa (Cep290) (Nephrocystin-6) (Fragment) CEP290 NPHP6 Bos taurus (Bovine) 1468 "cilium morphogenesis [GO:0060271]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of transcription, DNA-templated [GO:0045893]; protein transport [GO:0015031]" GO:0005634; GO:0005813; GO:0005829; GO:0015031; GO:0032391; GO:0034451; GO:0036038; GO:0045893; GO:0060271; GO:0090316 0 0 0 PF16574; D2GXS7 CHOYP_BRAFLDRAFT_241726.1.22 m.806 sp TRIM2_AILME 23.077 143 105 3 30 168 602 743 3.99E-06 50.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5ED84 CHOYP_DGRI_GH14766.1.1 m.27098 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 3.99E-11 69.7 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O14522 CHOYP_PTPRT.18.45 m.43064 sp PTPRT_HUMAN 29.229 739 476 23 215 923 717 1438 3.99E-72 264 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O75179 CHOYP_LOC581927.16.27 m.39978 sp ANR17_HUMAN 33.004 506 318 16 19 507 161 662 3.99E-58 212 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P06603 CHOYP_LOC584364.1.2 m.38132 sp TBA1_DROME 99.476 191 1 0 1 191 1 191 3.99E-139 400 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P06605 CHOYP_AAEL_AAEL013229.1.2 m.30358 sp TBA3_DROME 63.636 132 33 3 107 231 79 202 3.99E-44 156 TBA3_DROME reviewed Tubulin alpha-3 chain alphaTub84D TubA84D CG2512 Drosophila melanogaster (Fruit fly) 450 microtubule-based process [GO:0007017]; mitotic cytokinesis [GO:0000281] GO:0000281; GO:0003924; GO:0005200; GO:0005525; GO:0005811; GO:0005874; GO:0007017; GO:0017022; GO:0048471 0 0 0 PF00091;PF03953; P18460 CHOYP_BRAFLDRAFT_99630.5.9 m.36500 sp FGFR3_CHICK 31.514 403 237 14 964 1338 363 754 3.99E-44 177 FGFR3_CHICK reviewed Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (Tyrosine kinase receptor CEK2) FGFR3 CEK2 Gallus gallus (Chicken) 806 apoptotic process [GO:0006915]; positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0005886; GO:0006915; GO:0008284; GO:0016021 0 0 0 PF07679;PF00047;PF07714; P34737 CHOYP_LOC100744727.1.1 m.20867 sp RS15_PODAS 74.497 149 38 0 6 154 4 152 3.99E-81 239 RS15_PODAS reviewed 40S ribosomal protein S15 (S12) RPS15 AS1 Podospora anserina (Pleurage anserina) 152 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00203; P49013 CHOYP_NEMVEDRAFT_V1G52068.1.3 m.3871 sp FBP3_STRPU 54.872 195 88 0 1 195 193 387 3.99E-68 220 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P97603 CHOYP_NEO1.2.3 m.36392 sp NEO1_RAT 38.176 647 363 14 31 661 18 643 3.99E-119 390 NEO1_RAT reviewed Neogenin (Fragment) Neo1 Ngn Rattus norvegicus (Rat) 1377 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; iron ion homeostasis [GO:0055072]; negative regulation of neuron death [GO:1901215]; positive regulation of BMP signaling pathway [GO:0030513] GO:0004872; GO:0005887; GO:0007155; GO:0007411; GO:0030513; GO:0043025; GO:0055072; GO:1901215 0 0 0 PF00041;PF07679;PF13895;PF06583; P97864 CHOYP_CASP7.15.23 m.37922 sp CASP7_MOUSE 27.668 253 141 11 12 240 67 301 3.99E-18 84.7 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q1PSW8 CHOYP_BRAFLDRAFT_241726.8.22 m.23917 sp LIN41_MOUSE 26.087 138 90 3 232 359 699 834 3.99E-06 52.8 LIN41_MOUSE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to organic substance [GO:0071310]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of protein metabolic process [GO:0051246]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0017148; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051246; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0071310; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q2TAL6 CHOYP_LOC101158638.1.2 m.5931 sp VWC2_HUMAN 34.286 105 64 3 30 130 218 321 3.99E-11 62 VWC2_HUMAN reviewed Brorin (Brain-specific chordin-like protein) (von Willebrand factor C domain-containing protein 2) VWC2 UNQ739/PRO1434 Homo sapiens (Human) 325 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666] GO:0005604; GO:0005614; GO:0005615; GO:0010811; GO:0030054; GO:0030514; GO:0032281; GO:0045202; GO:0045666 0 0 0 PF00093; Q30NT6 CHOYP_FLELI_3104.1.1 m.46432 sp ANMK_SULDN 30.39 385 218 14 36 393 6 367 3.99E-41 152 ANMK_SULDN reviewed Anhydro-N-acetylmuramic acid kinase (EC 2.7.1.170) (AnhMurNAc kinase) anmK Suden_2071 Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) 368 "1,6-anhydro-N-acetyl-beta-muramic acid catabolic process [GO:0097175]; amino sugar metabolic process [GO:0006040]; carbohydrate metabolic process [GO:0005975]; peptidoglycan turnover [GO:0009254]" GO:0005524; GO:0005975; GO:0006040; GO:0009254; GO:0016301; GO:0016773; GO:0097175 "PATHWAY: Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. {ECO:0000255|HAMAP-Rule:MF_01270}.; PATHWAY: Cell wall biogenesis; peptidoglycan recycling. {ECO:0000255|HAMAP-Rule:MF_01270}." 0 0 PF03702; Q54BU4 CHOYP_BRAFLDRAFT_84327.2.2 m.18378 sp ABCB1_DICDI 45.283 318 158 4 197 504 307 618 3.99E-82 276 ABCB1_DICDI reviewed ABC transporter B family member 1 (ABC transporter ABCB.1) abcB1 mrpA DDB_G0293416 Dictyostelium discoideum (Slime mold) 909 chemotaxis [GO:0006935]; culmination involved in sorocarp development [GO:0031154]; hyperosmotic response [GO:0006972]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005524; GO:0005739; GO:0006810; GO:0006935; GO:0006972; GO:0016021; GO:0031154; GO:0042626; GO:0043190; GO:0055085 0 0 0 PF00664;PF00005; Q6AXP4 CHOYP_LOC578284.1.1 m.30568 sp CB081_RAT 39.216 153 89 3 5 157 13 161 3.99E-30 120 CB081_RAT reviewed Uncharacterized protein C2orf81 homolog 0 Rattus norvegicus (Rat) 597 0 0 0 0 0 PF15479; Q6DG03 CHOYP_DMTF1.1.2 m.12558 sp DMTF1_DANRE 49.436 443 168 10 214 605 111 548 3.99E-134 414 DMTF1_DANRE reviewed Cyclin-D-binding Myb-like transcription factor 1 dmtf1 si:dkey-153k10.8 zgc:92448 Danio rerio (Zebrafish) (Brachydanio rerio) 645 "cell cycle [GO:0007049]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007049 0 0 0 PF00249; Q6PCF9 CHOYP_BRAFLDRAFT_90902.1.2 m.36836 sp S38AA_XENLA 33.426 718 370 18 3 622 2 709 3.99E-109 364 S38AA_XENLA reviewed Putative sodium-coupled neutral amino acid transporter 10 (Solute carrier family 38 member 10) slc38a10 Xenopus laevis (African clawed frog) 1045 amino acid transport [GO:0006865]; sodium ion transport [GO:0006814] GO:0006814; GO:0006865; GO:0016021 0 0 cd06174; PF01490; Q6ZRR9 CHOYP_LOC100377058.1.1 m.22299 sp DCDC5_HUMAN 32.781 543 320 15 1018 1550 46 553 3.99E-73 261 DCDC5_HUMAN reviewed Doublecortin domain-containing protein 5 DCDC5 KIAA1493 Homo sapiens (Human) 648 intracellular signal transduction [GO:0035556] GO:0005622; GO:0035556 0 0 0 0 Q70FJ1 CHOYP_LOC100186299.6.6 m.52749 sp AKAP9_MOUSE 34.141 454 285 6 1654 2106 1678 2118 3.99E-45 186 AKAP9_MOUSE reviewed A-kinase anchor protein 9 (AKAP-9) (Protein kinase A-anchoring protein 9) (PRKA9) Akap9 Kiaa0803 Mus musculus (Mouse) 3797 microtubule nucleation [GO:0007020]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] GO:0000242; GO:0005737; GO:0005794; GO:0005795; GO:0005813; GO:0007020; GO:0007165; GO:0007283; GO:0036064; GO:0060009 0 0 0 PF10495; Q80T91 CHOYP_DRPR.1.2 m.58255 sp MEG11_MOUSE 38.158 228 125 5 93 309 200 422 3.99E-34 142 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8VDB2 CHOYP_BRAFLDRAFT_72229.1.2 m.159 sp ALG12_MOUSE 53.889 180 82 1 38 217 12 190 3.99E-57 191 ALG12_MOUSE reviewed "Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog)" Alg12 Mus musculus (Mouse) 486 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein N-linked glycosylation [GO:0006487] GO:0000030; GO:0005783; GO:0005789; GO:0006487; GO:0006488; GO:0016020; GO:0016021; GO:0052917 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03901; Q8WZ42 CHOYP_LOC100367089.2.4 m.1910 sp TITIN_HUMAN 34.783 92 60 0 1857 1948 104 195 3.99E-09 66.2 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q96QT6 CHOYP_BRAFLDRAFT_89536.1.1 m.26678 sp PHF12_HUMAN 44.77 478 194 12 3 421 9 475 3.99E-114 376 PHF12_HUMAN reviewed PHD finger protein 12 (PHD factor 1) (Pf1) PHF12 KIAA1523 Homo sapiens (Human) 1004 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0001106; GO:0003682; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016580; GO:0017053; GO:0035091; GO:0042393; GO:0045892 0 0 0 PF00628;PF16737; Q9BU19 CHOYP_EHI_060430.1.1 m.39759 sp ZN692_HUMAN 46.939 49 26 0 411 459 13 61 3.99E-07 56.2 ZN692_HUMAN reviewed Zinc finger protein 692 ZNF692 Homo sapiens (Human) 519 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q9EP86 CHOYP_TAAR12H.1.1 m.49691 sp NPFF1_RAT 22.848 302 213 7 79 367 55 349 3.99E-09 62 NPFF1_RAT reviewed Neuropeptide FF receptor 1 (G-protein coupled receptor 147) (RFamide-related peptide receptor OT7T022) Npffr1 Gpr147 Npff1 Rattus norvegicus (Rat) 432 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; response to peptide [GO:1901652] GO:0005887; GO:0007268; GO:0008188; GO:0032870; GO:0042277; GO:1901652 0 0 0 PF00001; Q9ESN6 CHOYP_TRIM2.35.59 m.38031 sp TRIM2_MOUSE 27.273 231 131 11 168 383 523 731 3.99E-11 68.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y6R7 CHOYP_BRAFLDRAFT_97038.1.1 m.6181 sp FCGBP_HUMAN 23.971 413 276 16 97 487 34 430 3.99E-10 66.6 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A9JTG5 CHOYP_HOIL1.2.3 m.54310 sp HOIL1_DANRE 43.034 567 284 12 372 934 183 714 4.00E-148 458 HOIL1_DANRE reviewed RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 6.3.2.-) (Heme-oxidized IRP2 ubiquitin ligase 1 homolog) (HOIL-1) rbck1 zgc:175152 Danio rerio (Zebrafish) (Brachydanio rerio) 714 embryonic cranial skeleton morphogenesis [GO:0048701]; otic vesicle morphogenesis [GO:0071600]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein linear polyubiquitination [GO:0097039] GO:0004842; GO:0008270; GO:0016874; GO:0043123; GO:0043130; GO:0043161; GO:0048701; GO:0071600; GO:0071797; GO:0097039 0 0 0 PF01485;PF16764;PF00641; B3EWY9 CHOYP_contig_044236 m.51154 sp MLP_ACRMI 28.064 1069 607 40 618 1616 387 1363 4.00E-98 353 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; C3YEM5 CHOYP_EFTS.1.2 m.15603 sp EFTS_BRAFL 45.192 208 101 4 19 213 22 229 4.00E-49 172 EFTS_BRAFL reviewed "Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt)" BRAFLDRAFT_84221 Branchiostoma floridae (Florida lancelet) (Amphioxus) 331 mitochondrial translational elongation [GO:0070125] GO:0003746; GO:0005759; GO:0070125 0 0 0 PF00889; O43174 CHOYP_BRAFLDRAFT_87630.1.1 m.30352 sp CP26A_HUMAN 40.456 482 271 6 58 523 15 496 4.00E-125 378 CP26A_HUMAN reviewed Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) CYP26A1 CYP26 P450RAI1 Homo sapiens (Human) 497 negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; retinoic acid catabolic process [GO:0034653]; retinoic acid metabolic process [GO:0042573]; vitamin metabolic process [GO:0006766]; xenobiotic metabolic process [GO:0006805] GO:0001972; GO:0005506; GO:0005789; GO:0006766; GO:0006805; GO:0008401; GO:0016709; GO:0019825; GO:0020037; GO:0031090; GO:0034653; GO:0042573; GO:0048387 0 0 0 PF00067; O61231 CHOYP_RPL10.1.2 m.4994 sp RL10_DROME 75.54 139 29 2 4 140 48 183 4.00E-70 214 RL10_DROME reviewed 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0043025; GO:0051297; GO:0051298 0 0 cd01433; PF00252; P0C691 CHOYP_LOC100492160.3.3 m.33211 sp DPOL_DHBV3 27.624 181 125 4 113 292 430 605 4.00E-08 59.3 DPOL_DHBV3 reviewed Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV) 786 DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006260; GO:0046872 0 0 0 PF00336;PF00242;PF00078; P10076 CHOYP_LOC100537361.1.1 m.55516 sp ZFP26_MOUSE 26.972 545 335 20 584 1112 274 771 4.00E-42 171 ZFP26_MOUSE reviewed Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) 861 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; P31597 CHOYP_LOC100691601.1.2 m.23328 sp EAA3_RABIT 49.343 533 213 11 63 592 12 490 4.00E-168 491 EAA3_RABIT reviewed Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 Oryctolagus cuniculus (Rabbit) 524 cysteine transport [GO:0042883]; D-aspartate import [GO:0070779]; L-glutamate transmembrane transport [GO:0089711] GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0016324; GO:0033229; GO:0042883; GO:0070779; GO:0089711 0 0 0 PF00375; P49321 CHOYP_BRAFLDRAFT_131259.1.1 m.49715 sp NASP_HUMAN 44.106 263 111 9 150 390 510 758 4.00E-55 197 NASP_HUMAN reviewed Nuclear autoantigenic sperm protein (NASP) NASP Homo sapiens (Human) 788 blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone exchange [GO:0043486]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574] GO:0000790; GO:0001824; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006334; GO:0006335; GO:0006336; GO:0007049; GO:0008283; GO:0008584; GO:0015031; GO:0032403; GO:0033574; GO:0043234; GO:0043486; GO:0051879 0 0 0 PF10516; P61255 CHOYP_LOC585872.2.6 m.44122 sp RL26_MOUSE 80.714 140 26 1 52 190 1 140 4.00E-79 235 RL26_MOUSE reviewed 60S ribosomal protein L26 (Silica-induced gene 20 protein) (SIG-20) Rpl26 Mus musculus (Mouse) 145 cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0002181; GO:0003735; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0044822; GO:0070062 0 0 0 PF00467;PF16906; Q32L09 CHOYP_CS066.3.3 m.64586 sp RYDEN_BOVIN 31.09 312 137 10 13 298 14 273 4.00E-32 124 RYDEN_BOVIN reviewed Repressor of yield of DENV protein homolog (RyDEN) RYDEN Bos taurus (Bovine) 290 defense response to virus [GO:0051607]; negative regulation of viral genome replication [GO:0045071]; response to interferon-gamma [GO:0034341]; response to type III interferon [GO:0034342]; response to type I interferon [GO:0034340] GO:0003723; GO:0005634; GO:0005737; GO:0034340; GO:0034341; GO:0034342; GO:0045071; GO:0051607 0 0 0 PF15135; Q3SZZ5 CHOYP_BRAFLDRAFT_275631.1.1 m.13403 sp TM208_BOVIN 54.43 158 68 1 3 156 1 158 4.00E-52 167 TM208_BOVIN reviewed Transmembrane protein 208 TMEM208 Bos taurus (Bovine) 173 autophagy [GO:0006914]; vacuolar protein processing [GO:0006624] GO:0005773; GO:0005789; GO:0006624; GO:0006914; GO:0016021 0 0 0 PF05620; Q460N5 CHOYP_BRAFLDRAFT_74879.2.6 m.23106 sp PAR14_HUMAN 24.751 703 491 16 2 688 421 1101 4.00E-53 202 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q495C1 CHOYP_LOC100891591.1.1 m.47143 sp RN212_HUMAN 38.596 114 68 2 21 134 1 112 4.00E-21 95.1 RN212_HUMAN reviewed Probable E3 SUMO-protein ligase RNF212 (EC 6.3.2.-) (RING finger protein 212) RNF212 Homo sapiens (Human) 297 chiasma assembly [GO:0051026]; meiotic gene conversion [GO:0006311]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131] GO:0005634; GO:0005694; GO:0006311; GO:0007131; GO:0008270; GO:0016874; GO:0016925; GO:0051026 PATHWAY: Protein modification; protein sumoylation. 0 0 PF14634; Q4R6I5 CHOYP_NELFD.1.1 m.60620 sp CLHC1_MACFA 28.448 232 160 2 30 261 346 571 4.00E-30 122 CLHC1_MACFA reviewed Clathrin heavy chain linker domain-containing protein 1 CLHC1 QtsA-17948 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 586 0 0 0 0 0 PF15739; Q5ND28 CHOYP_MEGF10.10.12 m.42852 sp SREC_MOUSE 36.81 163 97 5 194 354 215 373 4.00E-22 101 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q6ZRF8 CHOYP_LOC100369754.3.10 m.28518 sp RN207_HUMAN 24 200 137 7 17 214 103 289 4.00E-11 65.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7T163 CHOYP_LOC100641729.4.10 m.32915 sp KDIS_DANRE 35.821 268 156 9 798 1055 4 265 4.00E-26 120 KDIS_DANRE reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) 1672 nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; regulation of protein kinase activity [GO:0045859] GO:0005770; GO:0007399; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0045859 0 0 0 PF00023;PF12796;PF07693; Q8IT98 CHOYP_RS18.7.11 m.37165 sp RS18_ARGIR 85.714 77 11 0 1 77 27 103 4.00E-46 150 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q9R013 CHOYP_NEMVEDRAFT_V1G204928.1.2 m.15590 sp CATF_MOUSE 54.817 301 132 3 484 782 164 462 4.00E-108 341 CATF_MOUSE reviewed Cathepsin F (EC 3.4.22.41) Ctsf Mus musculus (Mouse) 462 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0008234; GO:0051603; GO:0070062; GO:1903561 0 0 0 PF08246;PF00112; F1M625 CHOYP_UBP16.1.1 m.38208 sp UBP46_RAT 36.634 101 61 2 126 225 36 134 4.01E-09 60.1 UBP46_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) Usp46 Rattus norvegicus (Rat) 366 "adult feeding behavior [GO:0008343]; behavioral fear response [GO:0001662]; behavioral response to ethanol [GO:0048149]; protein deubiquitination [GO:0016579]; regulation of synaptic transmission, GABAergic [GO:0032228]; righting reflex [GO:0060013]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0001662; GO:0004843; GO:0006511; GO:0008343; GO:0016579; GO:0032228; GO:0048149; GO:0060013 0 0 0 PF00443; P48725 CHOYP_LOC582174.6.16 m.32835 sp PCNT_MOUSE 34.351 131 81 3 1 129 2739 2866 4.01E-10 62.4 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; P49790 CHOYP_P121C.1.1 m.57092 sp NU153_HUMAN 30.213 470 224 23 923 1321 1017 1453 4.01E-08 62 NU153_HUMAN reviewed Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153) NUP153 Homo sapiens (Human) 1475 gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; negative regulation of RNA export from nucleus [GO:0046832]; nuclear pore complex assembly [GO:0051292]; protein import into nucleus [GO:0006606]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; tRNA export from nucleus [GO:0006409]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0003682; GO:0003690; GO:0005487; GO:0005642; GO:0005643; GO:0005654; GO:0005730; GO:0005737; GO:0006406; GO:0006409; GO:0006606; GO:0007067; GO:0007077; GO:0008139; GO:0008270; GO:0010827; GO:0016032; GO:0016925; GO:0017056; GO:0019083; GO:0031047; GO:0031965; GO:0034399; GO:0042405; GO:0042802; GO:0043495; GO:0044613; GO:0044615; GO:0046718; GO:0046832; GO:0051292; GO:0075732; GO:0075733; GO:1900034 0 0 0 PF08604;PF10599;PF00641; P62311 CHOYP_LSM3.1.1 m.9505 sp LSM3_MOUSE 84.314 102 16 0 8 109 1 102 4.01E-59 179 LSM3_MOUSE reviewed U6 snRNA-associated Sm-like protein LSm3 Lsm3 Mus musculus (Mouse) 102 "cytoplasmic mRNA processing body assembly [GO:0033962]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0000932; GO:0003723; GO:0005688; GO:0030629; GO:0033962; GO:0044822; GO:0046540; GO:0071011; GO:0071013; GO:1990726 0 0 0 PF01423; P78314 CHOYP_3BP2.3.3 m.35650 sp 3BP2_HUMAN 28.261 138 84 5 10 140 10 139 4.01E-08 58.5 3BP2_HUMAN reviewed SH3 domain-binding protein 2 (3BP-2) SH3BP2 3BP2 RES4-23 Homo sapiens (Human) 561 signal transduction [GO:0007165] GO:0005070; GO:0007165 0 0 0 PF00169;PF00017; Q08DD7 CHOYP_SNX10.1.1 m.14380 sp SNX11_BOVIN 40 130 75 2 11 139 17 144 4.01E-20 90.1 SNX11_BOVIN reviewed Sorting nexin-11 SNX11 Bos taurus (Bovine) 270 endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; vesicle organization [GO:0016050] GO:0005768; GO:0006886; GO:0006897; GO:0016050; GO:0019898; GO:0035091; GO:1901981 0 0 0 PF00787; Q10901 CHOYP_LOC592280.1.2 m.38904 sp EAA1_CAEEL 37.061 456 271 4 22 471 16 461 4.01E-103 320 EAA1_CAEEL reviewed Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) glt-1 C12D12.2 Caenorhabditis elegans 503 0 GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0042995 0 0 0 PF00375; Q28HW9 CHOYP_ISCW_ISCW008600.1.1 m.58788 sp CNEP1_XENTR 75.214 234 58 0 6 239 7 240 4.01E-134 380 CNEP1_XENTR reviewed CTD nuclear envelope phosphatase 1 (EC 3.1.3.16) (Serine/threonine-protein phosphatase dullard) ctdnep1 dullard TEgg035l07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 244 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; nuclear envelope organization [GO:0006998]; positive regulation of triglyceride biosynthetic process [GO:0010867]; protein dephosphorylation [GO:0006470] GO:0004721; GO:0004722; GO:0005635; GO:0005737; GO:0005789; GO:0006470; GO:0006998; GO:0007399; GO:0010867; GO:0016021; GO:0030154; GO:0031965; GO:0048471; GO:0071595 0 0 0 PF03031; Q5E9E4 CHOYP_SSRB.2.2 m.37284 sp SSRB_BOVIN 58.282 163 61 3 27 189 1 156 4.01E-62 194 SSRB_BOVIN reviewed Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta) SSR2 Bos taurus (Bovine) 183 0 GO:0005789; GO:0016021 0 0 0 0 Q6DRC4 CHOYP_EIF3G.1.1 m.29464 sp EIF3G_DANRE 62.081 298 99 10 15 305 1 291 4.01E-119 347 EIF3G_DANRE reviewed Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) eif3g eif3s4 Danio rerio (Zebrafish) (Brachydanio rerio) 293 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0000166; GO:0001731; GO:0003743; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290 0 0 cd12933; PF12353;PF00076; Q6GMR7 CHOYP_FAH2A.1.1 m.14027 sp FAAH2_HUMAN 49.425 522 258 2 10 525 9 530 4.01E-173 502 FAAH2_HUMAN reviewed Fatty-acid amide hydrolase 2 (EC 3.5.1.99) (Amidase domain-containing protein) (Anandamide amidohydrolase 2) (Oleamide hydrolase 2) FAAH2 AMDD Homo sapiens (Human) 532 arachidonic acid metabolic process [GO:0019369] GO:0005811; GO:0016021; GO:0016884; GO:0017064; GO:0019369; GO:0103073 0 0 0 PF01425; Q6PD74 CHOYP_AAGAB.1.1 m.15200 sp AAGAB_HUMAN 36.145 83 53 0 10 92 8 90 4.01E-11 61.2 AAGAB_HUMAN reviewed Alpha- and gamma-adaptin-binding protein p34 AAGAB Homo sapiens (Human) 315 protein transport [GO:0015031] GO:0005654; GO:0005737; GO:0005829; GO:0015031 0 0 0 PF10199; Q7TP17 CHOYP_U2AF1.1.2 m.26065 sp U2AF4_RAT 77.083 96 21 1 1 95 1 96 4.01E-47 154 U2AF4_RAT reviewed Splicing factor U2AF 26 kDa subunit (Liver regeneration-related protein LRRG157/LRRG158) (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) U2af1l4 Cb2-806 Cb2-807 Rattus norvegicus (Rat) 220 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005681; GO:0005737; GO:0016607; GO:0046872; GO:0089701 0 0 0 PF00076;PF00642; Q80VI1 CHOYP_NEMVEDRAFT_V1G198899.1.3 m.3461 sp TRI56_MOUSE 26.804 194 116 5 16 195 1 182 4.01E-10 63.5 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q9CUB6 CHOYP_LOAG_02445.1.1 m.31269 sp OTUD1_MOUSE 28.346 127 82 5 113 236 290 410 4.01E-07 53.9 OTUD1_MOUSE reviewed OTU domain-containing protein 1 (EC 3.4.19.12) Otud1 Mus musculus (Mouse) 454 protein K63-linked deubiquitination [GO:0070536] GO:0004843; GO:0070536 0 0 0 PF02338; Q9R229 CHOYP_BMP10.1.1 m.46420 sp BMP10_MOUSE 43.561 264 134 7 1 254 163 421 4.01E-64 208 BMP10_MOUSE reviewed Bone morphogenetic protein 10 (BMP-10) Bmp10 Mus musculus (Mouse) 421 "activin receptor signaling pathway [GO:0032924]; adult heart development [GO:0007512]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; BMP signaling pathway [GO:0030509]; cardiac muscle cell proliferation [GO:0060038]; cell adhesion [GO:0007155]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell proliferation involved in heart morphogenesis [GO:2000138]; positive regulation of gene expression [GO:0010628]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of apoptotic process [GO:0042981]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle hypertrophy in response to stress [GO:1903242]; regulation of MAPK cascade [GO:0043408]; SMAD protein signal transduction [GO:0060395]; ventricular cardiac muscle cell development [GO:0055015]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]" GO:0005125; GO:0005160; GO:0005179; GO:0005615; GO:0005737; GO:0007155; GO:0007507; GO:0007512; GO:0009986; GO:0010596; GO:0010613; GO:0010614; GO:0010628; GO:0010862; GO:0030018; GO:0030308; GO:0030336; GO:0030509; GO:0031433; GO:0032924; GO:0033612; GO:0042981; GO:0043408; GO:0045893; GO:0055009; GO:0055010; GO:0055015; GO:0055117; GO:0060038; GO:0060045; GO:0060298; GO:0060347; GO:0060389; GO:0060395; GO:0061036; GO:1903242; GO:2000138 0 0 0 PF00019;PF00688; O35920 CHOYP_LOC100882339.1.2 m.45806 sp CAN9_RAT 38.743 684 377 16 11 679 32 688 4.02E-160 480 CAN9_RAT reviewed Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) Capn9 Ncl4 Rattus norvegicus (Rat) 690 digestion [GO:0007586] GO:0004198; GO:0005509; GO:0005737; GO:0007586 0 0 0 PF01067;PF13833;PF00648; O96064 CHOYP_MYSP.6.9 m.40722 sp MYSP_MYTGA 76.957 230 53 0 89 318 566 795 4.02E-108 338 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P05149 CHOYP_contig_037216 m.41945 sp GALM_ACICA 38.776 98 56 1 53 146 28 125 4.02E-15 73.9 GALM_ACICA reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) (Type-1 mutarotase) mro Acinetobacter calcoaceticus 381 hexose metabolic process [GO:0019318] GO:0004034; GO:0019318; GO:0030246; GO:0042597 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; P10447 CHOYP_LOC100841619.1.1 m.40382 sp ABL_FSVHY 28.689 244 152 7 658 892 205 435 4.02E-14 80.1 ABL_FSVHY reviewed Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl) ABL Feline sarcoma virus (strain Hardy-Zuckerman 2) 439 0 GO:0004715; GO:0005524 0 0 0 PF07714;PF00017;PF00018; P34416 CHOYP_LOC663855.1.5 m.576 sp LASP1_CAEEL 45.26 327 133 4 1 286 1 322 4.02E-86 264 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P48725 CHOYP_LOC100368547.33.40 m.52702 sp PCNT_MOUSE 43.478 138 76 1 26 163 2693 2828 4.02E-25 105 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; P52564 CHOYP_MP2K6.1.1 m.38188 sp MP2K6_HUMAN 61.631 331 121 2 9 336 5 332 4.02E-146 419 MP2K6_HUMAN reviewed Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3) MAP2K6 MEK6 MKK6 PRKMK6 SKK3 Homo sapiens (Human) 334 "activation of MAPK activity [GO:0000187]; apoptotic process [GO:0006915]; cardiac muscle contraction [GO:0060048]; cell cycle arrest [GO:0007050]; cellular response to sorbitol [GO:0072709]; DNA damage induced protein phosphorylation [GO:0006975]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; ovulation cycle process [GO:0022602]; positive regulation of apoptotic process [GO:0043065]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of prostaglandin secretion [GO:0032308]; proteolysis in other organism [GO:0035897]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; response to ischemia [GO:0002931]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0000187; GO:0002931; GO:0004702; GO:0004708; GO:0004713; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0005856; GO:0006351; GO:0006355; GO:0006915; GO:0006975; GO:0007050; GO:0007165; GO:0019901; GO:0022602; GO:0032308; GO:0035897; GO:0042493; GO:0043065; GO:0051770; GO:0060048; GO:0070423; GO:0072709 0 0 0 PF00069; P56213 CHOYP_LOC100376688.2.8 m.15637 sp ALR_MOUSE 65.873 126 40 1 29 154 75 197 4.02E-61 190 ALR_MOUSE reviewed FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) Gfer Alr MNCb-0663 Mus musculus (Mouse) 198 0 GO:0005737; GO:0005739; GO:0005758; GO:0015035; GO:0016972; GO:0050660 0 0 0 PF04777; P86179 CHOYP_LPHN.1.1 m.51242 sp CSL3_ONCKE 42.105 95 50 2 61 151 6 99 4.02E-14 72.4 CSL3_ONCKE reviewed L-rhamnose-binding lectin CSL3 0 Oncorhynchus keta (Chum salmon) (Salmo keta) 195 0 GO:0001674; GO:0005534; GO:0005623; GO:0005737; GO:0033296; GO:0042564; GO:0042803; GO:0060473; GO:1903777 0 0 0 PF02140; Q05B50 CHOYP_LOC100075219.1.1 m.28895 sp THG1_BOVIN 59.124 274 101 3 1 271 30 295 4.02E-123 356 THG1_BOVIN reviewed Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (tRNA-histidine guanylyltransferase) THG1L Bos taurus (Bovine) 298 protein homotetramerization [GO:0051289]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033] GO:0000287; GO:0005524; GO:0005525; GO:0005739; GO:0006400; GO:0008033; GO:0008193; GO:0051289 0 0 0 PF04446;PF14413; Q0D2E8 CHOYP_BRAFLDRAFT_93651.1.1 m.13093 sp RFT1_XENTR 48.052 539 279 1 1 538 1 539 4.02E-170 495 RFT1_XENTR reviewed Protein RFT1 homolog rft1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 539 carbohydrate transport [GO:0008643]; glycolipid translocation [GO:0034203] GO:0005319; GO:0005789; GO:0008643; GO:0016021; GO:0034203 0 0 0 PF04506; Q5JTW2 CHOYP_LOC100368803.1.1 m.12857 sp CEP78_HUMAN 43.345 586 299 10 1 572 1 567 4.02E-152 465 CEP78_HUMAN reviewed Centrosomal protein of 78 kDa (Cep78) CEP78 C9orf81 Homo sapiens (Human) 689 G2/M transition of mitotic cell cycle [GO:0000086] GO:0000086; GO:0005813; GO:0005829 0 0 0 PF13516; Q62186 CHOYP_PHUM_PHUM548270.1.1 m.13004 sp SSRD_MOUSE 48 150 78 0 23 172 23 172 4.02E-52 167 SSRD_MOUSE reviewed Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta) Ssr4 Mus musculus (Mouse) 172 0 GO:0005789; GO:0016021; GO:0070062 0 0 0 PF05404; Q6TFL4 CHOYP_KLHL24.1.4 m.8833 sp KLH24_HUMAN 28.543 508 357 4 22 526 62 566 4.02E-66 229 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q8R1F9 CHOYP_LOC100650165.1.1 m.18364 sp RPP40_MOUSE 25.444 338 233 8 23 348 21 351 4.02E-23 102 RPP40_MOUSE reviewed Ribonuclease P protein subunit p40 (RNaseP protein p40) (EC 3.1.26.5) Rpp40 Mus musculus (Mouse) 363 tRNA 5'-leader removal [GO:0001682] GO:0001682; GO:0004526; GO:0005655 0 0 0 PF08584; Q9ESN6 CHOYP_TRIM3.22.58 m.32626 sp TRIM2_MOUSE 25.967 181 121 6 101 277 536 707 4.02E-08 57.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JI85 CHOYP_NUCB1.1.1 m.38180 sp NUCB2_RAT 48.169 355 174 3 6 351 12 365 4.02E-98 307 NUCB2_RAT reviewed Nucleobindin-2 (DNA-binding protein NEFA) (Prepronesfatin) [Cleaved into: Nesfatin-1] Nucb2 Nefa Rattus norvegicus (Rat) 420 insulin metabolic process [GO:1901142]; negative regulation of appetite [GO:0032099]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of testosterone secretion [GO:2000845]; response to glucose [GO:0009749]; response to human chorionic gonadotropin [GO:0044752]; response to melanocyte-stimulating hormone [GO:1990680]; response to starvation [GO:0042594] GO:0003677; GO:0005164; GO:0005509; GO:0005615; GO:0005635; GO:0005737; GO:0005783; GO:0005797; GO:0009749; GO:0016020; GO:0030818; GO:0032099; GO:0042594; GO:0044752; GO:0045599; GO:0046321; GO:0046627; GO:0070093; GO:1901142; GO:1990680; GO:2000845 0 0 0 PF13499; Q9Z2L6 CHOYP_MINP1.1.1 m.13284 sp MINP1_MOUSE 32.671 453 272 11 39 467 38 481 4.02E-70 233 MINP1_MOUSE reviewed "Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase)" Minpp1 Mipp MNCb-1572 Mus musculus (Mouse) 481 0 GO:0003993; GO:0005788; GO:0005886; GO:0034417; GO:0052826; GO:0070062 0 0 cd07061; PF00328; A1X283 CHOYP_SPD2B.1.1 m.26216 sp SPD2B_HUMAN 66.667 72 24 0 10 81 7 78 4.03E-30 115 SPD2B_HUMAN reviewed SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) SH3PXD2B FAD49 KIAA1295 TKS4 Homo sapiens (Human) 911 adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; oxidation-reduction process [GO:0055114]; podosome assembly [GO:0071800]; positive regulation of fat cell differentiation [GO:0045600]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide metabolic process [GO:0006801] GO:0001501; GO:0001654; GO:0002102; GO:0005737; GO:0006801; GO:0007507; GO:0010314; GO:0016176; GO:0022617; GO:0030054; GO:0030154; GO:0032266; GO:0042169; GO:0042995; GO:0045600; GO:0055114; GO:0060348; GO:0060612; GO:0070273; GO:0071800; GO:0072657; GO:0080025 0 0 0 PF00787;PF00018;PF07653; D2GXS7 CHOYP_BRAFLDRAFT_206799.10.23 m.32953 sp TRIM2_AILME 27.16 162 97 5 30 188 600 743 4.03E-08 57.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14523 CHOYP_LOC658718.2.2 m.41769 sp C2C2L_HUMAN 24.723 542 330 18 46 552 4 502 4.03E-25 114 C2C2L_HUMAN reviewed C2 domain-containing protein 2-like (Transmembrane protein 24) C2CD2L KIAA0285 TMEM24 DLNB23 Homo sapiens (Human) 706 positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] GO:0016021; GO:0035774 0 0 0 0 O15990 CHOYP_KARG.7.11 m.16761 sp KARG_LIOJA 70.652 92 26 1 143 233 1 92 4.03E-36 133 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O35426 CHOYP_BRAFLDRAFT_124528.1.1 m.39622 sp XBP1_MOUSE 42.439 205 91 5 15 192 52 256 4.03E-34 124 XBP1_MOUSE reviewed "X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" Xbp1 Treb5 Mus musculus (Mouse) 267 "adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; autophagy [GO:0006914]; cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation [GO:0002070]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; glucose homeostasis [GO:0042593]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; lipid metabolic process [GO:0006629]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein destabilization [GO:0031648]; protein transport [GO:0015031]; regulation of autophagy [GO:0010506]; regulation of protein stability [GO:0031647]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]" GO:0000122; GO:0000977; GO:0000981; GO:0001047; GO:0001085; GO:0001158; GO:0001525; GO:0001889; GO:0001934; GO:0001935; GO:0002070; GO:0002639; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006351; GO:0006357; GO:0006366; GO:0006511; GO:0006629; GO:0006914; GO:0006990; GO:0007517; GO:0010506; GO:0010508; GO:0010832; GO:0014065; GO:0015031; GO:0016049; GO:0030176; GO:0030968; GO:0031017; GO:0031062; GO:0031490; GO:0031647; GO:0031648; GO:0031670; GO:0032008; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035924; GO:0036312; GO:0042149; GO:0042593; GO:0042632; GO:0042826; GO:0042993; GO:0043066; GO:0043565; GO:0044212; GO:0044389; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051024; GO:0055089; GO:0055092; GO:0060612; GO:0060691; GO:0070059; GO:0071222; GO:0071230; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:1900100; GO:1900102; GO:1900103; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1990418; GO:2000347; GO:2000353; GO:2000778 0 0 0 PF07716; O43805 CHOYP_BRAFLDRAFT_57176.3.5 m.23440 sp SSNA1_HUMAN 69.027 113 35 0 39 151 1 113 4.03E-51 162 SSNA1_HUMAN reviewed Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa) SSNA1 NA14 Homo sapiens (Human) 119 ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; G2/M transition of mitotic cell cycle [GO:0000086]; intraciliary transport [GO:0042073] GO:0000086; GO:0005634; GO:0005813; GO:0005829; GO:0005886; GO:0036064; GO:0042073; GO:0042802; GO:0060830 0 0 0 0 O73791 CHOYP_LOC101243226.1.1 m.21378 sp TIE2_DANRE 30.208 96 45 4 3 77 223 317 4.03E-06 48.1 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; P18700 CHOYP_SMP_012720.2.2 m.34974 sp TBB_STRPU 95.868 121 5 0 1 121 102 222 4.03E-84 250 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P23398 CHOYP_UBI2P.1.1 m.51393 sp UBIQP_STRPU 99.107 112 1 0 1 112 21 132 4.03E-76 223 UBIQP_STRPU reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 133 0 GO:0005634; GO:0005737 0 0 0 PF00240; P28799 CHOYP_LOC100366380.2.4 m.22398 sp GRN_HUMAN 36.792 424 199 11 20 399 113 511 4.03E-71 237 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P28828 CHOYP_PTPRT.11.45 m.39468 sp PTPRM_MOUSE 39.123 570 334 8 883 1442 884 1450 4.03E-121 416 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P35224 CHOYP_LOC100533383.2.2 m.18662 sp CTNB_URECA 48.701 154 71 6 1 150 1 150 4.03E-29 114 CTNB_URECA reviewed Catenin beta (Beta-catenin) 0 Urechis caupo (Innkeeper worm) (Spoonworm) 818 adherens junction assembly [GO:0034333]; cell adhesion [GO:0007155] GO:0004871; GO:0005737; GO:0005856; GO:0007155; GO:0034333 0 0 0 PF00514; P36241 CHOYP_FUCO.1.2 m.58757 sp RL19_DROME 72.105 190 53 0 13 202 9 198 4.03E-87 258 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P40305 CHOYP_LUL4.1.2 m.35814 sp IFI27_HUMAN 51.136 88 37 2 154 241 36 117 4.03E-14 70.9 IFI27_HUMAN reviewed "Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a))" IFI27 Homo sapiens (Human) 119 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of protein export from nucleus [GO:0046825]; type I interferon signaling pathway [GO:0060337] GO:0000122; GO:0001102; GO:0005521; GO:0005637; GO:0005739; GO:0005741; GO:0006919; GO:0016021; GO:0046825; GO:0060337; GO:0097190 0 0 0 PF06140; P62323 CHOYP_LOC100115467.1.1 m.51329 sp SMD3_XENLA 82.407 108 17 1 1 106 1 108 4.03E-60 184 SMD3_XENLA reviewed Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) snrpd3 Xenopus laevis (African clawed frog) 126 spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0005685; GO:0005687; GO:0005829; GO:0034709; GO:0034715; GO:0034719; GO:0071208 0 0 0 PF01423; Q08874 CHOYP_MITF.3.3 m.26121 sp MITF_MOUSE 29.714 175 92 5 129 275 94 265 4.03E-11 66.6 MITF_MOUSE reviewed Microphthalmia-associated transcription factor Mitf Bw Mi Vit Mus musculus (Mouse) 526 "bone remodeling [GO:0046849]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; mast cell migration [GO:0097531]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoclast differentiation [GO:0030316]; pigmentation [GO:0043473]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein complex assembly [GO:0006461]; regulation of cell proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription, DNA-templated [GO:0006355]; Wnt signaling pathway [GO:0016055]" GO:0000122; GO:0000978; GO:0000979; GO:0001077; GO:0003677; GO:0003682; GO:0003700; GO:0003705; GO:0005634; GO:0006355; GO:0006461; GO:0010468; GO:0010628; GO:0016055; GO:0030154; GO:0030316; GO:0030318; GO:0042127; GO:0043010; GO:0043066; GO:0043234; GO:0043473; GO:0043565; GO:0044336; GO:0045165; GO:0045670; GO:0045893; GO:0045944; GO:0046849; GO:0097531; GO:2000144; GO:2001141 0 0 0 PF11851;PF00010;PF15951; Q14596 CHOYP_NBR1.1.1 m.18554 sp NBR1_HUMAN 26.849 730 351 25 5 687 5 598 4.03E-49 193 NBR1_HUMAN reviewed Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B) NBR1 1A13B KIAA0049 M17S2 MIG19 Homo sapiens (Human) 966 macroautophagy [GO:0016236]; negative regulation of osteoblast differentiation [GO:0045668]; protein oligomerization [GO:0051259]; regulation of bone mineralization [GO:0030500]; regulation of stress-activated MAPK cascade [GO:0032872] GO:0000407; GO:0005764; GO:0005770; GO:0005776; GO:0005829; GO:0008270; GO:0016020; GO:0016236; GO:0030500; GO:0031410; GO:0031430; GO:0032872; GO:0043130; GO:0045668; GO:0051019; GO:0051259; GO:0070062 0 0 cd14947; PF16158;PF00564;PF00569; Q2TGI5 CHOYP_LOC764485.2.2 m.9579 sp ZDH24_RAT 32.738 168 100 4 111 272 91 251 4.03E-20 91.3 ZDH24_RAT reviewed Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Membrane-associated zinc finger protein DHHC25) (Zinc finger DHHC domain-containing protein 24) (DHHC-24) Zdhhc24 Rattus norvegicus (Rat) 284 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q4J9D2 CHOYP_LOC100694656.1.1 m.37094 sp Y1252_SULAC 34.857 175 101 4 181 352 11 175 4.03E-21 94.7 Y1252_SULAC reviewed Uncharacterized protein Saci_1252 Saci_1252 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 181 0 0 0 0 0 PF01661; Q54KA7 CHOYP_AFUA_1G01020.28.50 m.38004 sp SECG_DICDI 36.62 284 146 1 1 250 195 478 4.03E-43 159 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q6KAQ7 CHOYP_BRAFLDRAFT_87547.1.1 m.44054 sp ZZZ3_MOUSE 44.218 441 202 8 63 475 484 908 4.03E-107 342 ZZZ3_MOUSE reviewed ZZ-type zinc finger-containing protein 3 Zzz3 Mus musculus (Mouse) 910 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005671; GO:0005730; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00249;PF00569; Q6P6M5 CHOYP_LOC100617731.1.1 m.4172 sp PX11C_MOUSE 31.878 229 140 4 24 246 11 229 4.03E-39 139 PX11C_MOUSE reviewed Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (Protein PEX11 homolog gamma) (PEX11-gamma) Pex11g Pex11c Mus musculus (Mouse) 241 peroxisome fission [GO:0016559]; regulation of peroxisome size [GO:0044375] GO:0005777; GO:0005779; GO:0016559; GO:0031231; GO:0043234; GO:0044375 0 0 0 PF05648; Q6P9H4 CHOYP_LOC100748006.1.2 m.19013 sp CNKR3_HUMAN 44.407 295 155 3 14 307 7 293 4.03E-72 244 CNKR3_HUMAN reviewed Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) CNKSR3 MAGI1 Homo sapiens (Human) 555 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765] GO:0005737; GO:0010765; GO:0016020; GO:0033137; GO:0070373 0 0 0 PF10534;PF06663;PF00595;PF00536; Q86Z23 CHOYP_contig_004963 m.5680 sp C1QL4_HUMAN 32.381 105 63 3 82 182 100 200 4.03E-06 49.3 C1QL4_HUMAN reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8C6K9 CHOYP_LOC100717588.1.1 m.37907 sp CO6A6_MOUSE 22.257 319 212 9 1 308 317 610 4.03E-10 64.7 CO6A6_MOUSE reviewed Collagen alpha-6(VI) chain Col6a6 Mus musculus (Mouse) 2265 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; Q9PU53 CHOYP_TERF1.1.1 m.19513 sp TERF2_CHICK 25.472 212 151 4 12 222 21 226 4.03E-14 77.8 TERF2_CHICK reviewed Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) TERF2 TRF2 Gallus gallus (Chicken) 718 cell cycle [GO:0007049]; telomere maintenance [GO:0000723]; telomeric loop formation [GO:0031627] GO:0000723; GO:0000781; GO:0000783; GO:0003691; GO:0005654; GO:0007049; GO:0031627; GO:0042162 0 0 cd11654; PF00249;PF16772;PF08558; H2A0N4 CHOYP_NRP.4.4 m.44647 sp PIF_PINMG 24.638 276 169 12 39 287 274 537 4.04E-10 65.9 PIF_PINMG reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada margaritifera (Black-lipped pearl oyster) 1014 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607;PF00092; O88281 CHOYP_CED1.25.29 m.52940 sp MEGF6_RAT 27.97 404 196 16 192 506 772 1169 4.04E-22 105 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P16419 CHOYP_LOC100897185.1.1 m.58373 sp MYPC2_CHICK 25.784 287 182 10 82 354 358 627 4.04E-10 67.4 MYPC2_CHICK reviewed "Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)" MYBPC2 Gallus gallus (Chicken) 1132 cell adhesion [GO:0007155] GO:0005623; GO:0007155; GO:0031672; GO:0032982 0 0 0 PF00041;PF07679; P18700 CHOYP_TBB.7.7 m.66814 sp TBB_STRPU 98.131 214 3 1 1 213 78 291 4.04E-158 441 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P20585 CHOYP_MSH3.2.2 m.63493 sp MSH3_HUMAN 42.636 387 213 6 2 381 367 751 4.04E-88 293 MSH3_HUMAN reviewed DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1) MSH3 DUC1 DUG Homo sapiens (Human) 1137 DNA repair [GO:0006281]; maintenance of DNA repeat elements [GO:0043570]; meiotic mismatch repair [GO:0000710]; mismatch repair [GO:0006298]; negative regulation of DNA recombination [GO:0045910]; positive regulation of helicase activity [GO:0051096]; reciprocal meiotic recombination [GO:0007131] GO:0000228; GO:0000710; GO:0003684; GO:0005524; GO:0005654; GO:0006281; GO:0006298; GO:0007131; GO:0016020; GO:0019899; GO:0030983; GO:0032302; GO:0043570; GO:0045910; GO:0051096 0 0 0 PF01624;PF05188;PF05192;PF00488; P28827 CHOYP_LOC100890753.3.3 m.61934 sp PTPRM_HUMAN 34.122 507 313 10 731 1222 903 1403 4.04E-79 290 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P50429 CHOYP_BRAFLDRAFT_206907.4.11 m.16717 sp ARSB_MOUSE 41.517 501 247 9 33 492 39 534 4.04E-136 406 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; P82596 CHOYP_LECG.2.4 m.27530 sp PLC_HALLA 35.664 143 85 4 20 161 2 138 4.04E-23 92.4 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q02357 CHOYP_TVAG_123950.26.31 m.61134 sp ANK1_MOUSE 36.9 271 171 0 2 272 183 453 4.04E-50 180 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q02357 CHOYP_TVAG_451090.9.13 m.61133 sp ANK1_MOUSE 40.291 206 123 0 2 207 233 438 4.04E-40 148 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q07409 CHOYP_LOC100901941.2.3 m.56630 sp CNTN3_MOUSE 25.824 364 248 12 21 379 91 437 4.04E-21 100 CNTN3_MOUSE reviewed Contactin-3 (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein) Cntn3 Pang Pcs Mus musculus (Mouse) 1028 cell adhesion [GO:0007155]; nervous system development [GO:0007399] GO:0005886; GO:0007155; GO:0007399; GO:0031225 0 0 0 PF00041;PF07679; Q08E52 CHOYP_ISCW_ISCW000704.1.1 m.38250 sp PAK1_BOVIN 37.132 272 141 6 62 311 75 338 4.04E-39 147 PAK1_BOVIN reviewed Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) PAK1 Bos taurus (Bovine) 544 actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; exocytosis [GO:0006887]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; wound healing [GO:0042060] GO:0001726; GO:0001934; GO:0004674; GO:0004702; GO:0005518; GO:0005524; GO:0005737; GO:0005794; GO:0005886; GO:0005911; GO:0005925; GO:0006468; GO:0006887; GO:0006915; GO:0007409; GO:0030036; GO:0030335; GO:0031532; GO:0032587; GO:0033138; GO:0033148; GO:0042060; GO:0043234; GO:0043507; GO:0046777; GO:0048754; GO:0051496; GO:0060244; GO:0071437 0 0 0 PF00786;PF00069; Q0IHY5 CHOYP_RL23A.6.6 m.63332 sp EMC7_XENTR 48.876 178 91 0 35 212 38 215 4.04E-62 196 EMC7_XENTR reviewed ER membrane protein complex subunit 7 emc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 237 0 GO:0016021; GO:0072546 0 0 0 PF09430; Q0VCR1 CHOYP_PHUM_PHUM177390.1.1 m.45457 sp RTF2_BOVIN 46.98 298 139 6 1 280 1 297 4.04E-83 254 RTF2_BOVIN reviewed Protein RTF2 homolog (Replication termination factor 2 domain-containing protein 1) RTFDC1 Bos taurus (Bovine) 299 mitotic DNA replication termination [GO:1902979] GO:0005634; GO:1902979 0 0 0 PF04641; Q1L908 CHOYP_LOC588008.1.1 m.41928 sp MSTO1_DANRE 35.233 579 350 12 4 565 6 576 4.04E-112 349 MSTO1_DANRE reviewed Protein misato homolog 1 msto1 si:dkey-263h23.5 zgc:55470 Danio rerio (Zebrafish) (Brachydanio rerio) 591 0 GO:0003924; GO:0005741 0 0 0 PF10644;PF14881; Q3A8Q0 CHOYP_NEMVEDRAFT_V1G175375.1.1 m.25756 sp PDXT_CARHZ 43.779 217 94 7 64 279 1 190 4.04E-49 164 PDXT_CARHZ reviewed Pyridoxal 5'-phosphate synthase subunit PdxT (EC 4.3.3.6) (Pdx2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) pdxT CHY_2702 Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) 191 glutamine catabolic process [GO:0006543]; pyridoxal phosphate biosynthetic process [GO:0042823]; vitamin B6 biosynthetic process [GO:0042819] GO:0004359; GO:0006543; GO:0036381; GO:0042819; GO:0042823 PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01615}. 0 cd01749; PF01174; Q54KA7 CHOYP_AFUA_1G01020.21.50 m.32737 sp SECG_DICDI 36.467 351 207 3 38 387 139 474 4.04E-50 184 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q54Q39 CHOYP_BRAFLDRAFT_119045.1.2 m.9906 sp PP1R7_DICDI 27.215 316 176 10 181 471 50 336 4.04E-21 98.2 PP1R7_DICDI reviewed Protein phosphatase 1 regulatory subunit pprA pprA DDB_G0284039 Dictyostelium discoideum (Slime mold) 336 0 GO:0005634 0 0 0 PF13855; Q6PCD5 CHOYP_BRAFLDRAFT_121302.2.2 m.31782 sp RFWD3_HUMAN 48.611 216 108 3 40 253 446 660 4.04E-62 211 RFWD3_HUMAN reviewed E3 ubiquitin-protein ligase RFWD3 (EC 6.3.2.-) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201) RFWD3 RNF201 Homo sapiens (Human) 774 DNA repair [GO:0006281]; mitophagy in response to mitochondrial depolarization [GO:0098779]; mitotic G1 DNA damage checkpoint [GO:0031571]; positive regulation of defense response to virus by host [GO:0002230]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; response to ionizing radiation [GO:0010212]; xenophagy [GO:0098792] GO:0002039; GO:0002230; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006281; GO:0008270; GO:0010212; GO:0016567; GO:0016605; GO:0016874; GO:0031571; GO:0097371; GO:0098779; GO:0098792; GO:2000001 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q863D9 CHOYP_SOX14.1.1 m.50393 sp SRY_ALCAC 35.484 93 59 1 401 493 42 133 4.04E-12 69.7 SRY_ALCAC reviewed Sex-determining region Y protein (Testis-determining factor) SRY TDF Alces alces cameloides (Ussuri moose) (Siberian moose) 229 "cell differentiation [GO:0030154]; male sex determination [GO:0030238]; sex differentiation [GO:0007548]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005737; GO:0006351; GO:0007548; GO:0016607; GO:0030154; GO:0030238 0 0 0 PF00505; Q8IUS5 CHOYP_LOC100376692.1.1 m.55900 sp EPHX4_HUMAN 46.602 309 154 7 39 340 51 355 4.04E-91 279 EPHX4_HUMAN reviewed Epoxide hydrolase 4 (EC 3.3.-.-) (Abhydrolase domain-containing protein 7) (Epoxide hydrolase-related protein) EPHX4 ABHD7 EPHXRP Homo sapiens (Human) 362 0 GO:0016021; GO:0016787 0 0 0 PF00561; Q8K2K6 CHOYP_LOC100371022.1.1 m.51315 sp AGFG1_MOUSE 35.971 556 239 19 2 506 4 493 4.04E-75 253 AGFG1_MOUSE reviewed Arf-GAP domain and FG repeat-containing protein 1 (HIV-1 Rev-binding protein homolog) (Nucleoporin-like protein RIP) Agfg1 Hrb Rip Mus musculus (Mouse) 561 acrosome assembly [GO:0001675]; intermediate filament organization [GO:0045109]; multicellular organism development [GO:0007275]; spermatid nucleus differentiation [GO:0007289]; transport [GO:0006810] GO:0001675; GO:0003677; GO:0005096; GO:0005634; GO:0006810; GO:0007275; GO:0007289; GO:0016023; GO:0042995; GO:0043025; GO:0043231; GO:0045109; GO:0046872 0 0 0 PF01412; Q9NFP5 CHOYP_SH3L1.3.5 m.12111 sp SH3BG_DROME 43.59 117 56 3 1 108 1 116 4.04E-24 100 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9S7P3 CHOYP_LOC576465.1.1 m.55908 sp KN7N_ARATH 32.323 198 132 2 75 270 51 248 4.04E-29 119 KN7N_ARATH reviewed Kinesin-like protein KIN-7N KIN7N ZCF125 At1g59540 T30E16.9 T4M14.11 Arabidopsis thaliana (Mouse-ear cress) 823 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005871; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF00225; A2AJ76 CHOYP_LOC100864449.2.2 m.34273 sp HMCN2_MOUSE 24.19 525 310 27 67 539 3023 3511 4.05E-19 97.4 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; O42602 CHOYP_CALRL.2.3 m.42463 sp CRFR1_XENLA 30.469 384 235 11 2 368 28 396 4.05E-40 150 CRFR1_XENLA reviewed Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) crhr1 crf1 Xenopus laevis (African clawed frog) 415 cell surface receptor signaling pathway [GO:0007166]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; corticotropin secretion [GO:0051458]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; regulation of corticosterone secretion [GO:2000852] GO:0007166; GO:0010579; GO:0015056; GO:0016021; GO:0031226; GO:0051458; GO:0071376; GO:2000852 0 0 0 PF00002;PF02793; P23142 CHOYP_BRAFLDRAFT_67738.1.1 m.61349 sp FBLN1_HUMAN 35.625 160 79 6 272 428 355 493 4.05E-16 85.1 FBLN1_HUMAN reviewed Fibulin-1 (FIBL-1) FBLN1 PP213 Homo sapiens (Human) 703 "blood coagulation, fibrin clot formation [GO:0072378]; embryo implantation [GO:0007566]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of transformation of host cell by virus [GO:1904188]; negative regulation of transforming growth factor-beta secretion [GO:2001202]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; viral process [GO:0016032]" GO:0001933; GO:0001968; GO:0005178; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0005604; GO:0005615; GO:0007162; GO:0007566; GO:0008022; GO:0010628; GO:0016032; GO:0016504; GO:0030198; GO:0032403; GO:0042802; GO:0048146; GO:0070051; GO:0070062; GO:0070373; GO:0071953; GO:0072378; GO:1900025; GO:1904188; GO:1904237; GO:2000146; GO:2000647; GO:2001202 0 0 0 PF12662;PF07645; P50429 CHOYP_BRAFLDRAFT_206907.11.11 m.60960 sp ARSB_MOUSE 42.072 473 231 8 1 435 49 516 4.05E-132 395 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; P70207 CHOYP_DGRI_GH23973.1.1 m.45548 sp PLXA2_MOUSE 29.429 666 392 26 6 648 594 1204 4.05E-73 261 PLXA2_MOUSE reviewed Plexin-A2 (Plex 2) (Plexin-2) Plxna2 Kiaa0463 Mus musculus (Mouse) 1894 branchiomotor neuron axon guidance [GO:0021785]; cell surface receptor signaling pathway [GO:0007166]; centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756] GO:0001756; GO:0002116; GO:0005886; GO:0005887; GO:0007166; GO:0017154; GO:0021785; GO:0021915; GO:0021935; GO:0030334; GO:0048841; GO:0051642; GO:0060037; GO:0060174; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q24372 CHOYP_LOC100871130.1.1 m.51661 sp LACH_DROME 30.201 298 196 5 46 338 43 333 4.05E-35 135 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q32L63 CHOYP_VTA1.1.1 m.36056 sp VTA1_BOVIN 48.052 308 142 4 6 306 10 306 4.05E-94 284 VTA1_BOVIN reviewed Vacuolar protein sorting-associated protein VTA1 homolog VTA1 Bos taurus (Bovine) 307 protein transport [GO:0015031] GO:0010008; GO:0015031 0 0 0 0 Q3SYV7 CHOYP_AGAP_AGAP009899.1.1 m.22725 sp ZN345_BOVIN 44.186 129 63 1 680 808 134 253 4.05E-25 114 ZN345_BOVIN reviewed Zinc finger protein 345 ZNF345 Bos taurus (Bovine) 487 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q4LDE5 CHOYP_LOC100367084.13.22 m.49297 sp SVEP1_HUMAN 23.563 696 420 28 212 834 434 1090 4.05E-33 144 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q4R6F2 CHOYP_LOC101405842.1.1 m.35214 sp EMARD_MACFA 33.865 251 156 6 6 252 7 251 4.05E-32 127 EMARD_MACFA reviewed Endoplasmic reticulum membrane-associated RNA degradation protein (ER membrane-associated RNA degradation protein) (Fragment) ERMARD QtsA-18153 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 668 multicellular organism development [GO:0007275] GO:0005789; GO:0007275; GO:0016021 0 0 0 PF13910; Q63HQ0 CHOYP_LOC100372482.1.1 m.61581 sp AP1AR_HUMAN 36.014 286 129 14 36 283 1 270 4.05E-23 99.8 AP1AR_HUMAN reviewed AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) AP1AR C4orf16 PRO0971 Homo sapiens (Human) 302 "cellular protein localization [GO:0034613]; negative regulation of cell motility [GO:2000146]; negative regulation of receptor recycling [GO:0001920]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; protein transport [GO:0015031]; regulation of Arp2/3 complex-mediated actin nucleation [GO:0034315]; vesicle targeting, trans-Golgi to endosome [GO:0048203]" GO:0001920; GO:0005769; GO:0005770; GO:0005794; GO:0005829; GO:0015031; GO:0019894; GO:0030133; GO:0034315; GO:0034613; GO:0035650; GO:0048203; GO:1900025; GO:2000146 0 0 0 PF15745; Q6WN34 CHOYP_LOC588375.1.1 m.66319 sp CRDL2_HUMAN 33.766 154 87 6 31 182 40 180 4.05E-15 80.5 CRDL2_HUMAN reviewed Chordin-like protein 2 (Breast tumor novel factor 1) (BNF-1) (Chordin-related protein 2) CHRDL2 BNF1 CHL2 UNQ765/PRO1557 Homo sapiens (Human) 429 cartilage development [GO:0051216]; cell differentiation [GO:0030154]; ossification [GO:0001503] GO:0001503; GO:0005615; GO:0005737; GO:0030154; GO:0051216 0 0 0 PF00093; Q7ZVG6 CHOYP_LOC100555807.1.1 m.41568 sp SIAH1_DANRE 79.336 271 54 1 21 289 12 282 4.05E-163 457 SIAH1_DANRE reviewed E3 ubiquitin-protein ligase Siah1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) siah1 zgc:56026 Danio rerio (Zebrafish) (Brachydanio rerio) 282 apoptotic process [GO:0006915]; multicellular organism development [GO:0007275]; neuron apoptotic process [GO:0051402]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007275; GO:0008270; GO:0016874; GO:0042787; GO:0043161; GO:0051402; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03145; Q8CHI8 CHOYP_BRAFLDRAFT_127252.1.1 m.16242 sp EP400_MOUSE 33.862 1134 586 32 1 1100 1142 2145 4.05E-161 553 EP400_MOUSE reviewed E1A-binding protein p400 (EC 3.6.4.-) (Domino homolog) (mDomino) (p400 kDa SWI2/SNF2-related protein) Ep400 Kiaa1498 Mus musculus (Mouse) 3072 histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967] GO:0000812; GO:0003677; GO:0003682; GO:0004386; GO:0005524; GO:0016607; GO:0035267; GO:0043967; GO:0043968 0 0 0 PF15790;PF00271;PF07529;PF00176; Q8ITC3 CHOYP_RS19.5.12 m.26847 sp RS19_ARGIR 75.177 141 34 1 19 159 1 140 4.05E-77 229 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8TDB6 CHOYP_DTX3L.3.4 m.57051 sp DTX3L_HUMAN 56.354 181 76 3 612 791 561 739 4.05E-58 214 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q8WZ42 CHOYP_LOC575058.1.1 m.9531 sp TITIN_HUMAN 33.199 994 533 23 3191 4122 942 1866 4.05E-128 461 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q96EG3 CHOYP_LOC592869.1.1 m.47138 sp ZN837_HUMAN 35.542 166 99 5 338 497 368 531 4.05E-22 103 ZN837_HUMAN reviewed Zinc finger protein 837 ZNF837 Homo sapiens (Human) 531 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q96LK0 CHOYP_BRAFLDRAFT_113959.1.1 m.29415 sp CEP19_HUMAN 42.405 158 88 1 29 183 5 162 4.05E-41 139 CEP19_HUMAN reviewed Centrosomal protein of 19 kDa (Cep19) CEP19 C3orf34 HSD5 Homo sapiens (Human) 163 0 GO:0000922; GO:0005813; GO:0005814; GO:0036064 0 0 0 PF14933; Q96PZ0 CHOYP_PUS7.1.1 m.53798 sp PUS7_HUMAN 41.256 589 303 6 91 677 109 656 4.05E-161 482 PUS7_HUMAN reviewed Pseudouridylate synthase 7 homolog (EC 5.4.99.-) PUS7 KIAA1897 Homo sapiens (Human) 661 pseudouridine synthesis [GO:0001522]; tRNA processing [GO:0008033] GO:0001522; GO:0005634; GO:0008033; GO:0009982; GO:0019899; GO:0044822 0 0 0 PF01142; Q96RW7 CHOYP_HMCN1.17.44 m.35887 sp HMCN1_HUMAN 23.478 345 211 13 78 396 3489 3806 4.05E-07 57.8 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9H0C1 CHOYP_BRAFLDRAFT_277528.1.1 m.10120 sp ZMY12_HUMAN 50.549 364 176 2 2 364 3 363 4.05E-127 372 ZMY12_HUMAN reviewed Zinc finger MYND domain-containing protein 12 ZMYND12 Homo sapiens (Human) 365 0 GO:0005622; GO:0046872 0 0 0 PF01753; Q9QZQ1 CHOYP_CBR-LET-2.2.2 m.44682 sp AFAD_MOUSE 28.947 228 126 8 963 1189 1466 1658 4.05E-07 58.5 AFAD_MOUSE reviewed Afadin (Protein Af-6) Mllt4 Af6 Mus musculus (Mouse) 1820 adherens junction maintenance [GO:0034334]; brain morphogenesis [GO:0048854]; cell adhesion [GO:0007155]; cerebral cortex development [GO:0021987]; establishment of endothelial intestinal barrier [GO:0090557]; homeostasis of number of cells [GO:0048872]; neuroepithelial cell differentiation [GO:0060563]; positive regulation of GTPase activity [GO:0043547]; protein localization to cell junction [GO:1902414]; radial glial cell differentiation [GO:0060019]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; signal transduction [GO:0007165]; telencephalon development [GO:0021537] GO:0005654; GO:0005737; GO:0005886; GO:0005911; GO:0005912; GO:0005913; GO:0007155; GO:0007165; GO:0017016; GO:0021537; GO:0021987; GO:0030054; GO:0034334; GO:0043296; GO:0043547; GO:0045177; GO:0048854; GO:0048872; GO:0050839; GO:0060019; GO:0060563; GO:0070445; GO:0090557; GO:1902414 0 0 0 PF01843;PF00498;PF00595;PF00788; A4IF63 CHOYP_BRAFLDRAFT_110072.7.8 m.47160 sp TRIM2_BOVIN 32.773 119 76 3 41 156 627 744 4.06E-10 60.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5PK63 CHOYP_RS17.3.11 m.11640 sp RS17_BOVIN 77.907 86 17 2 13 98 49 132 4.06E-41 134 RS17_BOVIN reviewed 40S ribosomal protein S17 RPS17 Bos taurus (Bovine) 135 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00833; A9ULZ2 CHOYP_LOC101166883.2.2 m.48764 sp BIR7B_XENLA 27.273 242 134 4 51 292 145 344 4.06E-20 92 BIR7B_XENLA reviewed Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) 345 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; O42401 CHOYP_LOC100636433.3.4 m.27077 sp MATN3_CHICK 34.466 206 125 5 269 468 45 246 4.06E-29 125 MATN3_CHICK reviewed Matrilin-3 MATN3 Gallus gallus (Chicken) 452 0 GO:0005509; GO:0005578 0 0 0 PF07645;PF10393;PF00092; O75095 CHOYP_MEG10.68.91 m.54373 sp MEGF6_HUMAN 39.906 213 122 3 95 307 856 1062 4.06E-39 157 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75179 CHOYP_LOC753709.18.44 m.35499 sp ANR17_HUMAN 34.082 490 260 20 453 891 236 713 4.06E-46 184 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_LOC100369333.27.32 m.53828 sp TRIM3_HUMAN 24.573 293 178 13 276 542 469 744 4.06E-08 59.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P04146 CHOYP_POLX.1.1 m.35889 sp COPIA_DROME 25.319 470 305 18 302 741 931 1384 4.06E-23 109 COPIA_DROME reviewed Copia protein (Gag-int-pol protein) [Cleaved into: Copia VLP protein; Copia protease (EC 3.4.23.-)] GIP COPIA Drosophila melanogaster (Fruit fly) 1409 DNA integration [GO:0015074] GO:0003676; GO:0004190; GO:0005524; GO:0008270; GO:0015074 0 0 0 PF13976;PF00665;PF07727;PF00098; P34269 CHOYP_TYR1.1.1 m.8497 sp TYR1_CAEEL 36.777 242 136 7 1 230 176 412 4.06E-39 155 TYR1_CAEEL reviewed Putative tyrosinase-like protein tyr-1 tyr-1 C02C2.1/C02C2.2 Caenorhabditis elegans 601 0 GO:0004497; GO:0046872 0 0 0 PF01549;PF00264; P42674 CHOYP_LOC580670.4.6 m.19320 sp BP10_PARLI 34.328 402 227 16 154 545 71 445 4.06E-54 196 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P70399 CHOYP_TP53B.1.1 m.6308 sp TP53B_MOUSE 36.04 505 281 16 1113 1598 1475 1956 4.06E-72 271 TP53B_MOUSE reviewed Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1) Tp53bp1 Trp53bp1 Mus musculus (Mouse) 1957 "cellular response to DNA damage stimulus [GO:0006974]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000077; GO:0000776; GO:0000777; GO:0000784; GO:0001102; GO:0001104; GO:0002039; GO:0003684; GO:0005634; GO:0005657; GO:0005737; GO:0006281; GO:0006351; GO:0006355; GO:0006974; GO:0008134; GO:0035064; GO:0042162; GO:0042393; GO:0043565; GO:0045944; GO:1990391 0 0 0 PF09038; P84175 CHOYP_LOC100376688.3.8 m.31104 sp RS12_CHICK 81.89 127 23 0 14 140 6 132 4.06E-73 217 RS12_CHICK reviewed 40S ribosomal protein S12 RPS12 Gallus gallus (Chicken) 132 translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0044822 0 0 0 PF01248; P86854 CHOYP_BRAFLDRAFT_223573.1.1 m.4526 sp PLCL_MYTGA 29.487 156 99 4 1 155 10 155 4.06E-17 76.6 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q01528 CHOYP_HAAF.5.13 m.16554 sp HAAF_LIMPO 33.884 121 76 2 1 121 1 117 4.06E-16 73.9 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q21268 CHOYP_CAOG_05080.1.1 m.32450 sp YMSO_CAEEL 33.468 248 113 8 43 276 62 271 4.06E-27 110 YMSO_CAEEL reviewed UPF0046 protein K07C11.7 K07C11.7 Caenorhabditis elegans 290 0 GO:0016787 0 0 0 PF00149; Q26613 CHOYP_EMAP.2.2 m.31237 sp EMAP_STRPU 63.399 153 56 0 5 157 41 193 4.06E-65 213 EMAP_STRPU reviewed 77 kDa echinoderm microtubule-associated protein EMAP Strongylocentrotus purpuratus (Purple sea urchin) 686 0 GO:0005737; GO:0005874 0 0 0 PF03451;PF00400; Q496A3 CHOYP_LOC100374662.5.6 m.22975 sp SPAS1_HUMAN 34.899 149 70 4 107 230 142 288 4.06E-13 70.5 SPAS1_HUMAN reviewed Spermatogenesis-associated serine-rich protein 1 SPATS1 Homo sapiens (Human) 300 0 0 0 0 0 PF15160; Q6PFY8 CHOYP_TRI45.10.23 m.32871 sp TRI45_MOUSE 30.049 203 122 5 5 195 127 321 4.06E-14 74.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8AWD2 CHOYP_MOCS3.1.1 m.14556 sp MOCS3_DANRE 54.989 451 190 6 26 470 16 459 4.06E-172 494 MOCS3_DANRE reviewed Adenylyltransferase and sulfurtransferase MOCS3 (Molybdenum cofactor synthesis protein 3) [Includes: Molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (Adenylyltransferase MOCS3) (Sulfur carrier protein MOCS2A adenylyltransferase); Molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (Sulfur carrier protein MOCS2A sulfurtransferase) (Sulfurtransferase MOCS3)] mocs3 uba4 zgc:55696 Danio rerio (Zebrafish) (Brachydanio rerio) 459 enzyme active site formation via cysteine modification to L-cysteine persulfide [GO:0018192]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble position uridine thiolation [GO:0002143]; tRNA wobble uridine modification [GO:0002098] GO:0002098; GO:0002143; GO:0004792; GO:0005524; GO:0005829; GO:0006777; GO:0016779; GO:0016783; GO:0018192; GO:0032447; GO:0034227; GO:0042292; GO:0046872; GO:0061604; GO:0061605; GO:0070733 PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03049}.; PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03049}. 0 0 PF00581;PF00899; Q8BG60 CHOYP_LOC100893521.1.1 m.31397 sp TXNIP_MOUSE 22.866 328 210 16 250 570 7 298 4.06E-08 59.3 TXNIP_MOUSE reviewed Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1) Txnip Vdup1 Mus musculus (Mouse) 397 "cell cycle [GO:0007049]; cellular response to tumor cell [GO:0071228]; keratinocyte differentiation [GO:0030216]; negative regulation of cell division [GO:0051782]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; protein import into nucleus [GO:0006606]; regulation of cell proliferation [GO:0042127]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to progesterone [GO:0032570]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0004857; GO:0005634; GO:0005737; GO:0005758; GO:0005829; GO:0006351; GO:0006606; GO:0006979; GO:0007049; GO:0009612; GO:0009749; GO:0030216; GO:0031625; GO:0032355; GO:0032570; GO:0042127; GO:0042493; GO:0042542; GO:0043065; GO:0048008; GO:0051592; GO:0051782; GO:0071228 0 0 0 PF02752;PF00339; Q924W6 CHOYP_LOC100891735.2.2 m.58038 sp TRI66_MOUSE 22.374 219 145 5 8 219 3 203 4.06E-06 51.2 TRI66_MOUSE reviewed Tripartite motif-containing protein 66 (Transcriptional intermediary factor 1 delta) Trim66 Tif1d Mus musculus (Mouse) 1242 "negative regulation of transcription, DNA-templated [GO:0045892]" GO:0003682; GO:0005634; GO:0005654; GO:0008270; GO:0010369; GO:0016235; GO:0042803; GO:0045892 0 0 0 PF00439;PF00628;PF00643; Q92546 CHOYP_SC61B.2.6 m.35944 sp RGP1_HUMAN 41.573 89 48 2 1 86 133 220 4.06E-14 69.7 RGP1_HUMAN reviewed RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog) RGP1 KIAA0258 Homo sapiens (Human) 391 "negative regulation of cellular protein catabolic process [GO:1903363]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000139; GO:0005829; GO:0016020; GO:0017112; GO:0017137; GO:0032588; GO:0034066; GO:0042147; GO:0043234; GO:0043547; GO:1903363 0 0 0 PF08737; Q96C23 CHOYP_RHOM172_0471.1.1 m.60636 sp GALM_HUMAN 38.776 343 199 8 64 401 5 341 4.06E-77 245 GALM_HUMAN reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM BLOCK25 Homo sapiens (Human) 342 galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006] GO:0004034; GO:0005737; GO:0006006; GO:0006012; GO:0030246; GO:0070062 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; Q96S53 CHOYP_TESK2.1.1 m.24980 sp TESK2_HUMAN 44.814 511 224 15 45 518 41 530 4.06E-121 374 TESK2_HUMAN reviewed Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) TESK2 Homo sapiens (Human) 571 actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283] GO:0004672; GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006468; GO:0007283; GO:0030036; GO:0046872; GO:0048041 0 0 0 PF07714; Q9BY67 CHOYP_IGFN3-4.2.2 m.43816 sp CADM1_HUMAN 24.775 222 157 6 102 317 113 330 4.06E-11 67.4 CADM1_HUMAN reviewed Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1) CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1 Homo sapiens (Human) 442 adherens junction organization [GO:0034332]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune system process [GO:0002376]; multicellular organism development [GO:0007275]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; spermatogenesis [GO:0007283]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271] GO:0002376; GO:0004872; GO:0005102; GO:0005886; GO:0005887; GO:0005911; GO:0005913; GO:0006915; GO:0007156; GO:0007157; GO:0007275; GO:0007283; GO:0008037; GO:0016323; GO:0030154; GO:0030165; GO:0034332; GO:0042271; GO:0042803; GO:0045202; GO:0045954; GO:0050715; GO:0050839; GO:0051606; GO:0070062 0 0 0 PF08205;PF07686; Q9GZT4 CHOYP_DAR1.1.4 m.4105 sp SRR_HUMAN 45.562 338 166 8 1 329 1 329 4.06E-90 276 SRR_HUMAN reviewed Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) SRR Homo sapiens (Human) 340 aging [GO:0007568]; brain development [GO:0007420]; D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; pyruvate biosynthetic process [GO:0042866]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to morphine [GO:0043278]; serine family amino acid metabolic process [GO:0009069] GO:0000287; GO:0003941; GO:0005509; GO:0005524; GO:0005737; GO:0005886; GO:0006563; GO:0007420; GO:0007568; GO:0008721; GO:0009069; GO:0016594; GO:0018114; GO:0030165; GO:0030170; GO:0030378; GO:0032496; GO:0042493; GO:0042803; GO:0042866; GO:0043025; GO:0043278; GO:0045177; GO:0051289; GO:0070178; GO:0070179 0 0 0 PF00291; A4IIY1 CHOYP_LOC100693263.1.1 m.58816 sp R144A_XENTR 27.746 173 100 6 122 285 59 215 4.07E-07 53.9 R144A_XENTR reviewed Probable E3 ubiquitin-protein ligase RNF144A (EC 6.3.2.-) (RING finger protein 144A) rnf144a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 292 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005794; GO:0008270; GO:0016021; GO:0016874; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; B7Z0K8 CHOYP_CG42342.1.1 m.23266 sp COLL1_DROME 40.794 277 102 8 119 355 527 781 4.07E-23 104 COLL1_DROME reviewed Collagen alpha chain CG42342 CG42342 Drosophila melanogaster (Fruit fly) 822 0 GO:0005581; GO:0005886; GO:0016021 0 0 0 PF01391; D2GXS7 CHOYP_BRAFLDRAFT_109858.2.6 m.32546 sp TRIM2_AILME 21.818 330 225 11 145 455 429 744 4.07E-07 56.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E7EYQ9 CHOYP_LOC591901.2.3 m.41250 sp TM216_DANRE 41.722 151 87 1 13 163 11 160 4.07E-32 115 TM216_DANRE reviewed Transmembrane protein 216 tmem216 Danio rerio (Zebrafish) (Brachydanio rerio) 160 cilium assembly [GO:0042384] GO:0005737; GO:0005856; GO:0016021; GO:0042384; GO:0042995 0 0 0 PF09799; O18023 CHOYP_LOC100909364.1.1 m.52840 sp IGDB2_CAEEL 21.98 505 326 14 298 752 426 912 4.07E-23 111 IGDB2_CAEEL reviewed Ig-like and fibronectin type-III domain-containing protein 2 igdb-2 C25G4.10 Caenorhabditis elegans 1526 cardiac muscle fiber development [GO:0048739]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493] GO:0005886; GO:0016021; GO:0030018; GO:0030334; GO:0048739; GO:0051015; GO:0051493 0 0 0 PF01682;PF00041;PF00047;PF14625; O70277 CHOYP_BRAFLDRAFT_84670.1.3 m.20610 sp TRIM3_RAT 28.333 120 81 3 37 153 627 744 4.07E-07 51.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_87279.2.10 m.17217 sp TRIM3_HUMAN 27.168 173 97 6 87 257 598 743 4.07E-08 57.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O94901 CHOYP_SUN2.1.1 m.6661 sp SUN1_HUMAN 38.684 380 202 9 602 969 452 812 4.07E-74 264 SUN1_HUMAN reviewed SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) SUN1 KIAA0810 UNC84A Homo sapiens (Human) 812 cytoskeletal anchoring at nuclear membrane [GO:0090286]; nuclear envelope organization [GO:0006998]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; ossification [GO:0001503]; response to mechanical stimulus [GO:0009612]; synapsis [GO:0007129] GO:0001503; GO:0002080; GO:0005635; GO:0005639; GO:0006998; GO:0007129; GO:0009612; GO:0031965; GO:0034993; GO:0043231; GO:0090286; GO:0090292 0 0 0 PF09387;PF07738; P15308 CHOYP_BRAFLDRAFT_190162.3.5 m.12109 sp B4_XENLA 41.538 65 31 1 15 79 49 106 4.07E-07 52.4 B4_XENLA reviewed Protein B4 (Histone H1-like protein) (Linker histone B4) b4 Xenopus laevis (African clawed frog) 273 multicellular organism development [GO:0007275]; nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0007275 0 0 0 PF00538; Q08257 CHOYP_CRYZ.1.2 m.16850 sp QOR_HUMAN 53.894 321 148 0 10 330 7 327 4.07E-123 359 QOR_HUMAN reviewed Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) CRYZ Homo sapiens (Human) 329 protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178] GO:0003730; GO:0003960; GO:0005737; GO:0005829; GO:0007601; GO:0008270; GO:0042178; GO:0051289; GO:0070062; GO:0070402 0 0 0 PF08240;PF00107; Q08CA1 CHOYP_LOC100883864.1.1 m.41792 sp GDPP1_DANRE 49.55 222 95 4 111 327 7 216 4.07E-67 217 GDPP1_DANRE reviewed GDP-D-glucose phosphorylase 1 (EC 2.7.7.78) gdpgp1 zgc:153343 Danio rerio (Zebrafish) (Brachydanio rerio) 343 glucose metabolic process [GO:0006006] GO:0000166; GO:0005085; GO:0005737; GO:0006006; GO:0016779; GO:0016787; GO:0080048 0 0 0 0 Q24K15 CHOYP_FCNV1.1.1 m.56137 sp ANGP4_BOVIN 39.474 228 128 6 84 308 275 495 4.07E-56 192 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q25145 CHOYP_TPM.17.19 m.63919 sp TPM_HALRU 63.958 283 102 0 1 283 1 283 4.07E-112 328 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q27268 CHOYP_LOC101067857.1.1 m.36992 sp DX39B_DROME 88.95 181 20 0 1 181 244 424 4.07E-118 343 DX39B_DROME reviewed ATP-dependent RNA helicase WM6 (DEAD box protein UAP56) (Dmrnahel) (EC 3.6.4.13) (HEL/UAP56) Hel25E Dbp25F hel WM6 CG7269 Drosophila melanogaster (Fruit fly) 424 "cellular response to DNA damage stimulus [GO:0006974]; chromatin remodeling [GO:0006338]; mitotic spindle organization [GO:0007052]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA secondary structure unwinding [GO:0010501]" GO:0000381; GO:0000398; GO:0003723; GO:0003724; GO:0004004; GO:0005524; GO:0005634; GO:0005681; GO:0005875; GO:0006338; GO:0006406; GO:0006974; GO:0007052; GO:0010501; GO:0016607 0 0 0 PF00270;PF00271; Q28I85 CHOYP_LOC100378584.1.3 m.38091 sp POC1A_XENTR 75 216 51 1 1 216 105 317 4.07E-119 354 POC1A_XENTR reviewed POC1 centriolar protein homolog A (Pat-interacting protein 2) (Pix2) (xPix2) (WD repeat-containing protein 51A) poc1a wdr51a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 441 0 GO:0005737; GO:0005856 0 0 0 PF00400; Q3TZX8 CHOYP_NOL9.2.2 m.24749 sp NOL9_MOUSE 30.769 585 332 16 377 932 141 681 4.07E-72 256 NOL9_MOUSE reviewed Polynucleotide 5'-hydroxyl-kinase NOL9 (EC 2.7.1.-) (Nucleolar protein 9) Nol9 Mus musculus (Mouse) 714 "cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000448]; maturation of 5.8S rRNA [GO:0000460]" GO:0000448; GO:0000460; GO:0003723; GO:0005524; GO:0005634; GO:0005730; GO:0016020; GO:0051731 0 0 0 PF16575; Q3ZMH1 CHOYP_BRAFLDRAFT_68831.1.1 m.64207 sp SC5A8_DANRE 53.846 78 36 0 16 93 10 87 4.07E-21 89.7 SC5A8_DANRE reviewed Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (zSMCTe) (Sodium solute symporter family 5 member 8 protein) (Solute carrier family 5 member 8) slc5a8 slc5a8l smcte zgc:152716 Danio rerio (Zebrafish) (Brachydanio rerio) 610 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293; GO:0015355 0 0 0 PF00474; Q4R642 CHOYP_LOC100378816.1.1 m.10997 sp TCTE1_MACFA 51.404 463 217 6 41 498 23 482 4.07E-163 475 TCTE1_MACFA reviewed T-complex-associated testis-expressed protein 1 (Tcte-1) TCTE1 QtsA-19176 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 501 0 0 0 0 0 PF13516; Q4UMH6 CHOYP_LOC755594.1.6 m.48633 sp Y381_RICFE 29.568 301 177 10 121 416 802 1072 4.07E-23 105 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q6CX49 CHOYP_LOC100370113.1.2 m.37729 sp VAC8_KLULA 37.5 104 58 3 189 292 111 207 4.07E-07 56.6 VAC8_KLULA reviewed Vacuolar protein 8 VAC8 KLLA0A11286g Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) 579 "CVT vesicle assembly [GO:0071255]; macroautophagy [GO:0016236]; nucleus-vacuole junction assembly [GO:0071562]; vacuole fusion, non-autophagic [GO:0042144]; vacuole inheritance [GO:0000011]" GO:0000011; GO:0000329; GO:0005794; GO:0016236; GO:0042144; GO:0071255; GO:0071561; GO:0071562; GO:0071563 0 0 0 PF00514; Q82IZ1 CHOYP_LOC100181826.1.1 m.16288 sp PTLH_STRAW 25.543 184 106 8 124 290 90 259 4.07E-07 54.3 PTLH_STRAW reviewed 1-deoxypentalenic acid 11-beta-hydroxylase (EC 1.14.11.35) (Neopentalenolactone biosynthesis protein H) ptlH SAV_2991 Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) 285 antibiotic biosynthetic process [GO:0017000]; lactone biosynthetic process [GO:1901336]; oxidation-reduction process [GO:0055114] GO:0005506; GO:0016706; GO:0017000; GO:0031418; GO:0055114; GO:1901336 PATHWAY: Antibiotic biosynthesis; neopentalenolactone biosynthesis. {ECO:0000269|PubMed:21250661}. 0 0 PF05721; Q8BLH7 CHOYP_LOC100378607.2.2 m.18562 sp HIRP3_MOUSE 30 150 84 3 588 722 455 598 4.07E-08 60.5 HIRP3_MOUSE reviewed HIRA-interacting protein 3 Hirip3 Mus musculus (Mouse) 601 0 GO:0005634; GO:0005730 0 0 0 PF09649; Q8C0D4 CHOYP_ARHGAP12B.1.2 m.36731 sp RHG12_MOUSE 31.315 859 509 29 30 848 19 836 4.07E-96 322 RHG12_MOUSE reviewed Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) Arhgap12 Mus musculus (Mouse) 838 morphogenesis of an epithelial sheet [GO:0002011]; signal transduction [GO:0007165] GO:0002011; GO:0005096; GO:0007165 0 0 0 PF00169;PF00620;PF14604;PF00397; Q8WTR2 CHOYP_LOC100366822.1.1 m.26605 sp DUS19_HUMAN 41.606 137 77 2 11 146 66 200 4.07E-26 101 DUS19_HUMAN reviewed Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1) DUSP19 DUSP17 LMWDSP3 SKRP1 Homo sapiens (Human) 217 negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860] GO:0004725; GO:0004860; GO:0005078; GO:0006469; GO:0008579; GO:0030295; GO:0031435; GO:0043410; GO:0043507; GO:0043508; GO:0045860; GO:0046329; GO:0046330 0 0 0 PF00782; Q96JI7 CHOYP_BRAFLDRAFT_78622.3.3 m.16756 sp SPTCS_HUMAN 27.843 1099 658 29 234 1288 482 1489 4.07E-107 378 SPTCS_HUMAN reviewed Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) 2443 axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; synaptic vesicle transport [GO:0048489] GO:0005730; GO:0005737; GO:0005765; GO:0005829; GO:0005886; GO:0007268; GO:0008088; GO:0030424; GO:0030425; GO:0031410; GO:0045202; GO:0048489; GO:0048675; GO:0070062 0 0 0 PF14649; Q9BXJ4 CHOYP_BRAFLDRAFT_89395.2.3 m.44585 sp C1QT3_HUMAN 33.962 106 67 2 56 160 118 221 4.07E-10 60.5 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9H4E5 CHOYP_RHOJ.1.2 m.14051 sp RHOJ_HUMAN 30 210 124 7 61 261 14 209 4.07E-17 81.3 RHOJ_HUMAN reviewed Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein) RHOJ ARHJ RASL7B RHOI TCL Homo sapiens (Human) 214 actin cytoskeleton organization [GO:0030036]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; Rho protein signal transduction [GO:0007266] GO:0003924; GO:0005525; GO:0005829; GO:0005886; GO:0007266; GO:0008360; GO:0030036; GO:0051056; GO:0061299; GO:0070062 0 0 0 PF00071; Q9R0M0 CHOYP_CELR2.6.8 m.38391 sp CELR2_MOUSE 25.685 292 183 10 164 442 1920 2190 4.07E-16 85.9 CELR2_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Flamingo homolog) Celsr2 Mus musculus (Mouse) 2920 "cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0042384]; cilium movement [GO:0003341]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of transcription, DNA-templated [GO:0006355]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]" GO:0001764; GO:0003341; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0016021; GO:0016055; GO:0021591; GO:0021999; GO:0032880; GO:0033326; GO:0042384 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9U221 CHOYP_BRAFLDRAFT_287444.3.5 m.17689 sp UNG_CAEEL 59.777 179 69 2 4 181 103 279 4.07E-75 229 UNG_CAEEL reviewed Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung-1 Y56A3A.29 Caenorhabditis elegans 282 base-excision repair [GO:0006284] GO:0004844; GO:0005634; GO:0005739; GO:0006284 0 0 cd10027; PF03167; A4IF63 CHOYP_BRAFLDRAFT_69798.1.22 m.3243 sp TRIM2_BOVIN 25.161 155 110 3 6 158 593 743 4.08E-08 55.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B3EWZ6 CHOYP_TRIADDRAFT_59472.1.1 m.34033 sp MLRP2_ACRMI 28.416 1471 845 64 1363 2719 722 2098 4.08E-111 404 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D8PJU0 CHOYP_NEMVEDRAFT_V1G6787.1.1 m.26961 sp VELB_SCHCM 37.5 64 40 0 25 88 194 257 4.08E-08 55.5 VELB_SCHCM reviewed Velvet complex subunit B velB SCHCODRAFT_255145 Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus) 536 "regulation of transcription, DNA-templated [GO:0006355]; sporulation resulting in formation of a cellular spore [GO:0030435]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0030435 0 0 0 PF11754; E9PV24 CHOYP_BRAFLDRAFT_86801.1.1 m.27107 sp FIBA_MOUSE 34.026 385 194 17 217 558 417 784 4.08E-48 182 FIBA_MOUSE reviewed Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] Fga Mus musculus (Mouse) 789 "acute-phase response [GO:0006953]; adaptive immune response [GO:0002250]; blood coagulation [GO:0007596]; blood coagulation, common pathway [GO:0072377]; blood coagulation, fibrin clot formation [GO:0072378]; cell-matrix adhesion [GO:0007160]; cellular protein complex assembly [GO:0043623]; cellular response to granulocyte colony-stimulating factor [GO:1990643]; cellular response to interleukin-6 [GO:0071354]; cellular response to organic cyclic compound [GO:0071407]; fibrinolysis [GO:0042730]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; liver regeneration [GO:0097421]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; plasminogen activation [GO:0031639]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exocytosis [GO:0045921]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of peptide hormone secretion [GO:0090277]; positive regulation of protein secretion [GO:0050714]; positive regulation of vasoconstriction [GO:0045907]; protein complex assembly [GO:0006461]; protein polymerization [GO:0051258]; response to calcium ion [GO:0051592]; response to cycloheximide [GO:0046898]; response to estradiol [GO:0032355]; response to genistein [GO:0033595]; response to morphine [GO:0043278]; signal transduction [GO:0007165]" GO:0002250; GO:0005198; GO:0005577; GO:0005615; GO:0005791; GO:0005938; GO:0006461; GO:0006953; GO:0007160; GO:0007165; GO:0007596; GO:0009897; GO:0009986; GO:0031091; GO:0031639; GO:0032355; GO:0033595; GO:0034116; GO:0042730; GO:0043152; GO:0043278; GO:0043623; GO:0045087; GO:0045907; GO:0045921; GO:0046872; GO:0046898; GO:0050714; GO:0051258; GO:0051592; GO:0070062; GO:0070374; GO:0070527; GO:0071354; GO:0071407; GO:0072377; GO:0072378; GO:0072562; GO:0090277; GO:0097421; GO:1902042; GO:1903561; GO:1990643; GO:2000352 0 0 0 PF08702;PF12160;PF00147; P07882 CHOYP_LOC100367670.1.2 m.14656 sp CEL_RAT 33.835 399 225 13 2 391 154 522 4.08E-51 184 CEL_RAT reviewed Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) Cel Rattus norvegicus (Rat) 612 lipid catabolic process [GO:0016042]; modulation of synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; synapse assembly [GO:0007416] GO:0004622; GO:0004771; GO:0004806; GO:0004872; GO:0005615; GO:0005737; GO:0005791; GO:0005794; GO:0005829; GO:0005887; GO:0007158; GO:0007416; GO:0009986; GO:0016042; GO:0032403; GO:0042043; GO:0042588; GO:0043208; GO:0043231; GO:0043234; GO:0045121; GO:0045202; GO:0050253; GO:0050804; GO:0052689 0 0 0 PF00135; P23640 CHOYP_RB27A.1.1 m.35759 sp RB27A_RAT 71.649 194 55 0 22 215 2 195 4.08E-108 313 RB27A_RAT reviewed Ras-related protein Rab-27A (Rab-27) (GTP-binding protein Ram) (Ram p25) Rab27a Rab27 Rattus norvegicus (Rat) 221 antigen processing and presentation [GO:0019882]; blood coagulation [GO:0007596]; complement-dependent cytotoxicity [GO:0097278]; cytotoxic T cell degranulation [GO:0043316]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; melanocyte differentiation [GO:0030318]; melanosome transport [GO:0032402]; multivesicular body organization [GO:0036257]; multivesicular body sorting pathway [GO:0071985]; natural killer cell degranulation [GO:0043320]; positive regulation of constitutive secretory pathway [GO:1903435]; positive regulation of exocytosis [GO:0045921]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulated secretory pathway [GO:1903307]; protein targeting [GO:0006605]; small GTPase mediated signal transduction [GO:0007264] GO:0001750; GO:0003924; GO:0005525; GO:0005764; GO:0005794; GO:0006605; GO:0006887; GO:0007264; GO:0007596; GO:0010628; GO:0016324; GO:0019003; GO:0019882; GO:0019904; GO:0030141; GO:0030318; GO:0030425; GO:0030667; GO:0032402; GO:0032585; GO:0033093; GO:0036257; GO:0042470; GO:0043316; GO:0043320; GO:0045921; GO:0050766; GO:0070062; GO:0070382; GO:0071985; GO:0097278; GO:1903307; GO:1903428; GO:1903435; GO:1990182 0 0 0 PF00071; P40112 CHOYP_BRAFLDRAFT_281217.1.1 m.15677 sp PSB3_RAT 79.512 205 42 0 1 205 1 205 4.08E-126 357 PSB3_RAT reviewed Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain) Psmb3 Rattus norvegicus (Rat) 205 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0051603 0 0 0 PF00227; P51957 CHOYP_LOC100184532.1.1 m.51581 sp NEK4_HUMAN 67.302 315 94 2 4 310 3 316 4.08E-143 444 NEK4_HUMAN reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) 841 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; P55214 CHOYP_CASP7.13.23 m.35463 sp CASP7_MESAU 29.24 171 97 7 12 174 67 221 4.08E-12 67 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q14162 CHOYP_MEG10.52.91 m.46950 sp SREC_HUMAN 30.645 310 146 13 197 478 119 387 4.08E-21 100 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q1PSW8 CHOYP_contig_054032 m.64606 sp LIN41_MOUSE 25.899 139 94 3 71 208 697 827 4.08E-07 54.3 LIN41_MOUSE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to organic substance [GO:0071310]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of protein metabolic process [GO:0051246]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0017148; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051246; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0071310; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q29RK9 CHOYP_LOC100372881.1.1 m.4636 sp MOB3B_BOVIN 70.857 175 51 0 10 184 4 178 4.08E-97 283 MOB3B_BOVIN reviewed MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) MOB3B MOBKL2B Bos taurus (Bovine) 216 0 GO:0046872 0 0 0 PF03637; Q460N3 CHOYP_PARP14.21.22 m.64513 sp PAR15_HUMAN 31.325 249 142 8 345 568 103 347 4.08E-21 100 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q55GU0 CHOYP_LOC100382522.2.2 m.57502 sp Y9955_DICDI 40.107 187 94 6 584 767 657 828 4.08E-27 121 Y9955_DICDI reviewed Probable serine/threonine-protein kinase DDB_G0267514 (EC 2.7.11.1) DDB_G0267514 Dictyostelium discoideum (Slime mold) 916 0 GO:0004674; GO:0005524 0 0 0 PF07714; Q62655 CHOYP_ITF2.1.1 m.1446 sp ITF2_RAT 72.115 104 28 1 96 198 464 567 4.08E-40 151 ITF2_RAT reviewed Transcription factor 4 (TCF-4) (Immunoglobulin transcription factor 2) (ITF-2) (RITF-2) (R8f DNA-binding protein) (SL3-3 enhancer factor 2) (SEF-2) Tcf4 Itf2 Sef2 Rattus norvegicus (Rat) 589 "positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003690; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0042803; GO:0043425; GO:0045666; GO:0045944; GO:0046982; GO:0070888 0 0 0 PF00010; Q8JZL1 CHOYP_IL17RA.2.2 m.66951 sp I17RD_MOUSE 22.011 368 220 13 233 589 206 517 4.08E-11 70.1 I17RD_MOUSE reviewed Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (Interleukin-17 receptor-like protein) (Sef homolog) (mSef) Il17rd Il17rlm Sef Mus musculus (Mouse) 738 0 GO:0000139; GO:0005654; GO:0005794; GO:0005887; GO:0030368; GO:0046872 0 0 0 PF16742;PF08357; Q92685 CHOYP_LOC576672.1.1 m.16944 sp ALG3_HUMAN 53.237 417 179 5 10 417 26 435 4.08E-137 402 ALG3_HUMAN reviewed "Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) (Asparagine-linked glycosylation protein 3 homolog) (Dol-P-Man-dependent alpha(1-3)-mannosyltransferase) (Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase) (Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase) (Not56-like protein)" ALG3 NOT NOT56L Homo sapiens (Human) 438 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486] GO:0000033; GO:0005789; GO:0006486; GO:0006488; GO:0016021; GO:0052925 PATHWAY: Protein modification; protein glycosylation. 0 0 PF05208; Q9U639 CHOYP_HSP70-3.1.1 m.19150 sp HSP7D_MANSE 87.815 238 25 1 8 245 6 239 4.08E-150 436 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9Y2D1 CHOYP_APCREB2.1.1 m.62327 sp ATF5_HUMAN 47.5 80 39 1 67 143 196 275 4.08E-15 73.6 ATF5_HUMAN reviewed Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx) ATF5 ATFX Homo sapiens (Human) 282 "cerebellar granule cell precursor proliferation [GO:0021930]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; olfactory bulb interneuron development [GO:0021891]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; regulation of centrosome cycle [GO:0046605]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]" GO:0000977; GO:0000981; GO:0001228; GO:0003682; GO:0003700; GO:0003714; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005813; GO:0006355; GO:0006357; GO:0007623; GO:0008285; GO:0009791; GO:0015631; GO:0019900; GO:0021891; GO:0021930; GO:0035264; GO:0043066; GO:0043565; GO:0044212; GO:0045444; GO:0045892; GO:0045893; GO:0045944; GO:0046605; GO:0048712; GO:1902750 0 0 0 PF00170; E1BD59 CHOYP_NEMVEDRAFT_V1G220841.1.1 m.37475 sp TRI56_BOVIN 24.161 298 184 9 7 285 21 295 4.09E-12 72 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O70277 CHOYP_contig_020799 m.23952 sp TRIM3_RAT 25.161 155 110 3 4 155 592 743 4.09E-09 58.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P05400 CHOYP_contig_015465 m.18036 sp POL_CERV 28.155 206 118 7 31 223 462 650 4.09E-08 58.9 POL_CERV reviewed Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Carnation etched ring virus (CERV) 659 0 GO:0003964; GO:0004190; GO:0004519 0 0 0 PF02160;PF00078; P06731 CHOYP_CEACAM5.3.5 m.26056 sp CEAM5_HUMAN 26.383 235 118 12 147 360 280 480 4.09E-06 52.4 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; P09481 CHOYP_LOC100368788.1.2 m.5131 sp ACHA3_CHICK 28.011 357 245 6 2 351 4 355 4.09E-51 182 ACHA3_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) 496 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; P15941 CHOYP_RGD1561408.1.2 m.4308 sp MUC1_HUMAN 38.027 902 422 38 1771 2617 127 946 4.09E-46 188 MUC1_HUMAN reviewed Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] MUC1 PUM Homo sapiens (Human) 1255 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; O-glycan processing [GO:0016266]; positive regulation of histone H4 acetylation [GO:0090240]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]" GO:0000790; GO:0000978; GO:0002039; GO:0003712; GO:0005615; GO:0005796; GO:0005887; GO:0006977; GO:0006978; GO:0010944; GO:0016266; GO:0016324; GO:0031982; GO:0033629; GO:0036003; GO:0043618; GO:0070062; GO:0090240; GO:1902166 0 0 0 PF01390; P16157 CHOYP_AASI_1435.23.35 m.54481 sp ANK1_HUMAN 37.379 206 113 3 564 769 177 366 4.09E-26 119 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16951 CHOYP_LOC100485532.1.1 m.25081 sp ATF2_MOUSE 35.616 511 199 18 5 488 3 410 4.09E-69 234 ATF2_MOUSE reviewed Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (MXBP protein) (cAMP response element-binding protein CRE-BP1) Atf2 Mus musculus (Mouse) 487 "adipose tissue development [GO:0060612]; amelogenesis [GO:0097186]; cellular response to DNA damage stimulus [GO:0006974]; fat cell differentiation [GO:0045444]; intra-S DNA damage checkpoint [GO:0031573]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; outflow tract morphogenesis [GO:0003151]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transforming growth factor beta2 production [GO:0032915]; regulation of transcription, DNA-templated [GO:0006355]; response to osmotic stress [GO:0006970]; response to water deprivation [GO:0009414]" GO:0000122; GO:0000977; GO:0000980; GO:0001077; GO:0001102; GO:0001158; GO:0003151; GO:0003677; GO:0003682; GO:0003700; GO:0004402; GO:0005634; GO:0005654; GO:0005737; GO:0005741; GO:0006355; GO:0006970; GO:0006974; GO:0008140; GO:0009414; GO:0016020; GO:0019901; GO:0031573; GO:0032915; GO:0035497; GO:0035861; GO:0043525; GO:0045444; GO:0045944; GO:0046872; GO:0050680; GO:0051091; GO:0060612; GO:0097186; GO:1902110 0 0 0 PF00170; P68037 CHOYP_LOC100378760.1.1 m.37015 sp UB2L3_MOUSE 77.273 154 35 0 15 168 1 154 4.09E-86 252 UB2L3_MOUSE reviewed Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (UbcM4) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3) Ube2l3 Ubce7 Mus musculus (Mouse) 154 "cell cycle phase transition [GO:0044770]; cell proliferation [GO:0008283]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to steroid hormone stimulus [GO:0071383]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein K11-linked ubiquitination [GO:0070979]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000209; GO:0003713; GO:0004842; GO:0005524; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008283; GO:0016567; GO:0031398; GO:0031625; GO:0042787; GO:0044770; GO:0044822; GO:0051443; GO:0061631; GO:0070062; GO:0070979; GO:0071383; GO:0071385; GO:0097027; GO:1903955 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q14642 CHOYP_LOC100743250.1.1 m.12309 sp I5P1_HUMAN 51.33 376 176 5 1 371 17 390 4.09E-135 397 I5P1_HUMAN reviewed "Type I inositol 1,4,5-trisphosphate 5-phosphatase (5PTase) (EC 3.1.3.56)" INPP5A Homo sapiens (Human) 412 inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol dephosphorylation [GO:0046856] GO:0004445; GO:0005886; GO:0016020; GO:0042731; GO:0043647; GO:0046856; GO:0052658; GO:0052659; GO:0070062 0 0 0 0 Q2KJ44 CHOYP_PTPA.1.1 m.18579 sp PTPA_BOVIN 56.467 317 138 0 44 360 7 323 4.09E-133 385 PTPA_BOVIN reviewed "Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')" PPP2R4 Bos taurus (Bovine) 324 mitotic spindle organization in nucleus [GO:0030472]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphoprotein phosphatase activity [GO:0032516] GO:0000159; GO:0003755; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0008160; GO:0008601; GO:0016887; GO:0030472; GO:0032515; GO:0032516; GO:0034704; GO:0043065; GO:0070062 0 0 cd04087; PF03095; Q3SZR9 CHOYP_LOC100742160.1.1 m.28818 sp TSN3_BOVIN 30.519 154 91 6 55 202 42 185 4.09E-07 53.5 TSN3_BOVIN reviewed Tetraspanin-3 (Tspan-3) TSPAN3 Bos taurus (Bovine) 253 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q3TT38 CHOYP_CF106.1.1 m.14354 sp CF106_MOUSE 57.589 224 89 4 1 222 4 223 4.09E-87 265 CF106_MOUSE reviewed Uncharacterized protein C6orf106 homolog D17Wsu92e Mus musculus (Mouse) 291 macroautophagy [GO:0016236] GO:0000407; GO:0005776; GO:0016236; GO:0043130 0 0 cd14947; PF16158; Q5RFD6 CHOYP_LOC100879369.1.1 m.41805 sp CBPM_PONAB 51.429 350 166 3 14 359 15 364 4.09E-124 370 CBPM_PONAB reviewed Carboxypeptidase M (CPM) (EC 3.4.17.12) CPM Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 443 0 GO:0004181; GO:0005886; GO:0008270; GO:0031225 0 0 0 PF00246; Q6NRE4 CHOYP_RL8.10.10 m.65635 sp GARE1_XENLA 55.556 54 24 0 209 262 802 855 4.09E-11 67.4 GARE1_XENLA reviewed GRB2-associated and regulator of MAPK protein (GRB2-associated and regulator of MAPK1) garem1 fam59a garem Xenopus laevis (African clawed frog) 876 cellular response to epidermal growth factor stimulus [GO:0071364]; epidermal growth factor receptor signaling pathway [GO:0007173]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0007173; GO:0008284; GO:0051781; GO:0070064; GO:0070374; GO:0071364 0 0 0 PF12736; Q8CF89 CHOYP_BRAFLDRAFT_259980.1.1 m.17609 sp TAB1_MOUSE 46.107 488 242 8 26 509 16 486 4.09E-133 399 TAB1_MOUSE reviewed TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) Tab1 Map3k7ip1 Mus musculus (Mouse) 502 activation of MAPKKK activity [GO:0000185]; aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0000185; GO:0001701; GO:0003007; GO:0003279; GO:0004722; GO:0005654; GO:0005737; GO:0007179; GO:0019209; GO:0030324; GO:0035904; GO:0060976 0 0 0 PF00481; Q96GP6 CHOYP_BRAFLDRAFT_69967.1.1 m.60222 sp SREC2_HUMAN 39.487 195 103 7 174 364 236 419 4.09E-27 116 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q99N92 CHOYP_LOC101159300.1.1 m.26609 sp RM27_MOUSE 40.323 124 66 3 29 146 24 145 4.09E-19 81.3 RM27_MOUSE reviewed "39S ribosomal protein L27, mitochondrial (L27mt) (MRP-L27)" Mrpl27 Mus musculus (Mouse) 148 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005762; GO:0006412; GO:0044822 0 0 0 PF01016; Q9BRR8 CHOYP_GPTC1.1.1 m.14864 sp GPTC1_HUMAN 42.985 784 347 22 3 717 7 759 4.09E-180 550 GPTC1_HUMAN reviewed G patch domain-containing protein 1 (Evolutionarily conserved G-patch domain-containing protein) GPATCH1 ECGP GPATC1 Homo sapiens (Human) 931 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003676; GO:0071013 0 0 0 PF07713;PF01585; Q9BUH6 CHOYP_LOC578349.1.1 m.51923 sp PAXX_HUMAN 29.586 169 112 2 37 201 37 202 4.09E-12 65.5 PAXX_HUMAN reviewed Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein) C9orf142 PAXX XLS Homo sapiens (Human) 204 cellular response to DNA damage stimulus [GO:0006974]; DNA ligation involved in DNA repair [GO:0051103]; double-strand break repair via nonhomologous end joining [GO:0006303] GO:0005634; GO:0006303; GO:0006974; GO:0032947; GO:0035861; GO:0042803; GO:0051103; GO:0070062; GO:0070419 0 0 0 PF15384; Q9ESN6 CHOYP_BRAFLDRAFT_89819.2.4 m.20578 sp TRIM2_MOUSE 26.857 175 114 7 23 190 536 703 4.09E-06 49.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GKX2 CHOYP_LOC764565.1.1 m.3966 sp DHRS4_RABIT 54.167 264 112 3 19 277 1 260 4.09E-99 293 DHRS4_RABIT reviewed Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (Peroxisomal short-chain alcohol dehydrogenase) (PSCD) (rabNRDR) (Fragment) DHRS4 Oryctolagus cuniculus (Rabbit) 260 0 GO:0004090; GO:0005739; GO:0005777 0 0 0 0 Q9NQ86 CHOYP_LOC100374741.63.83 m.53311 sp TRI36_HUMAN 26.582 158 101 4 33 190 206 348 4.09E-06 52 TRI36_HUMAN reviewed E3 ubiquitin-protein ligase TRIM36 (EC 6.3.2.-) (RING finger protein 98) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) TRIM36 RBCC728 RNF98 Homo sapiens (Human) 728 acrosome reaction [GO:0007340]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726] GO:0000209; GO:0001669; GO:0004842; GO:0005829; GO:0005856; GO:0007340; GO:0008270; GO:0016874; GO:0051726; GO:0070062 0 0 0 PF00041;PF00643;PF13445; Q9UGM3 CHOYP_DMBT1.18.34 m.37706 sp DMBT1_HUMAN 38.114 509 239 12 1 437 546 1050 4.09E-83 282 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A4IF63 CHOYP_contig_041876 m.48001 sp TRIM2_BOVIN 24.201 219 143 6 311 516 536 744 4.10E-06 53.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6H603 CHOYP_LOC100368100.1.1 m.28609 sp NWD1_MOUSE 26.41 390 253 10 155 531 4 372 4.10E-34 141 NWD1_MOUSE reviewed NACHT domain- and WD repeat-containing protein 1 Nwd1 Mus musculus (Mouse) 1563 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; G5ED84 CHOYP_BACH1.2.17 m.6276 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 4.10E-11 69.7 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; G5ED84 CHOYP_LOC100698240.2.4 m.14964 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 4.10E-11 69.7 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O43399 CHOYP_AAEL_AAEL007173.1.1 m.41471 sp TPD54_HUMAN 35.714 182 84 3 50 231 55 203 4.10E-28 108 TPD54_HUMAN reviewed Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) 206 regulation of cell proliferation [GO:0042127] GO:0005737; GO:0042127; GO:0042803; GO:0044822; GO:0046982; GO:0048471 0 0 0 PF04201; O62640 CHOYP_LOC100741028.2.4 m.41801 sp PIAP_PIG 36.332 289 161 9 287 568 86 358 4.10E-52 185 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P04962 CHOYP_CCNA.1.1 m.19222 sp CCNA_SPISO 81.452 124 23 0 1 124 185 308 4.10E-69 216 CCNA_SPISO reviewed G2/mitotic-specific cyclin-A 0 Spisula solidissima (Atlantic surf-clam) 422 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134;PF16500; P10079 CHOYP_LOC100632098.12.13 m.59436 sp FBP1_STRPU 53.241 432 202 0 1 432 193 624 4.10E-144 440 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P14373 CHOYP_LOC100373444.38.79 m.34685 sp TRI27_HUMAN 25.592 211 147 3 52 254 86 294 4.10E-07 54.7 TRI27_HUMAN reviewed Zinc finger protein RFP (EC 6.3.2.-) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27) TRIM27 RFP RNF76 Homo sapiens (Human) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell proliferation [GO:0008283]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003676; GO:0003677; GO:0004714; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005887; GO:0006351; GO:0006469; GO:0007283; GO:0008270; GO:0008283; GO:0016020; GO:0016605; GO:0016874; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0042802; GO:0045087; GO:0045814; GO:0046872; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; P16157 CHOYP_TVAG_227760.2.4 m.32724 sp ANK1_HUMAN 37.295 244 153 0 9 252 220 463 4.10E-44 162 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P29317 CHOYP_EPHA8.1.1 m.54116 sp EPHA2_HUMAN 26.408 284 175 11 461 733 659 919 4.10E-16 87.8 EPHA2_HUMAN reviewed Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) EPHA2 ECK Homo sapiens (Human) 976 activation of GTPase activity [GO:0090630]; angiogenesis [GO:0001525]; axial mesoderm formation [GO:0048320]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; multicellular organism development [GO:0007275]; negative regulation of protein kinase B signaling [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; post-anal tail morphogenesis [GO:0036342]; protein kinase B signaling [GO:0043491]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570]; viral process [GO:0016032] GO:0001501; GO:0001525; GO:0001570; GO:0001649; GO:0004714; GO:0005003; GO:0005524; GO:0005622; GO:0005886; GO:0005887; GO:0005913; GO:0005925; GO:0007275; GO:0008630; GO:0009986; GO:0010591; GO:0014028; GO:0016032; GO:0016477; GO:0021915; GO:0030182; GO:0030216; GO:0030316; GO:0031256; GO:0031258; GO:0032587; GO:0033598; GO:0033628; GO:0036342; GO:0043491; GO:0043535; GO:0045765; GO:0046849; GO:0048013; GO:0048320; GO:0051898; GO:0060035; GO:0060326; GO:0060444; GO:0070309; GO:0070372; GO:0070848; GO:0090004; GO:0090630; GO:0098641 0 0 0 PF14575;PF01404;PF00041;PF07714;PF00536; P31674 CHOYP_ISCW_ISCW016148.1.6 m.34162 sp RS15_ORYSJ 74.074 81 21 0 55 135 31 111 4.10E-36 125 RS15_ORYSJ reviewed 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) 154 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00203; P35408 CHOYP_PE2R3.1.2 m.43870 sp PE2R4_HUMAN 25 376 229 11 3 330 2 372 4.10E-28 117 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; P42577 CHOYP_FRIS.5.11 m.43768 sp FRIS_LYMST 80.612 98 18 1 2 98 4 101 4.10E-53 166 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P55265 CHOYP_DSRAD.4.4 m.58238 sp DSRAD_HUMAN 34.652 733 382 18 49 696 503 1223 4.10E-110 363 DSRAD_HUMAN reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) 1226 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337] GO:0001649; GO:0001701; GO:0002244; GO:0002566; GO:0003677; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006397; GO:0006606; GO:0006611; GO:0009615; GO:0016020; GO:0016553; GO:0030218; GO:0031054; GO:0035280; GO:0035455; GO:0043066; GO:0044387; GO:0044530; GO:0044822; GO:0045070; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060216; GO:0060337; GO:0060339; GO:0061484; GO:0098586; GO:1900369 0 0 0 PF02137;PF00035;PF02295; P58003 CHOYP_BRAFLDRAFT_219671.1.2 m.2689 sp SESN1_XENLA 47.541 488 233 9 10 481 1 481 4.10E-154 450 SESN1_XENLA reviewed Sestrin-1 (EC 1.11.1.15) (XPA26) (p53-regulated protein PA26) sesn1 pa26 Xenopus laevis (African clawed frog) 481 negative regulation of TORC1 signaling [GO:1904262]; regulation of response to reactive oxygen species [GO:1901031] GO:0005634; GO:0005737; GO:0051920; GO:0070728; GO:1901031; GO:1904262 0 0 0 PF04636; Q14315 CHOYP_LOAG_03940.1.1 m.61605 sp FLNC_HUMAN 32.867 143 84 4 22 155 426 565 4.10E-11 63.5 FLNC_HUMAN reviewed Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) FLNC ABPL FLN2 Homo sapiens (Human) 2725 cell junction assembly [GO:0034329]; muscle fiber development [GO:0048747] GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0008092; GO:0016528; GO:0030018; GO:0030506; GO:0034329; GO:0042383; GO:0043034; GO:0048747 0 0 0 PF00307;PF00630; Q15262 CHOYP_LOC100909333.1.1 m.49397 sp PTPRK_HUMAN 34.155 568 337 7 125 689 904 1437 4.10E-94 328 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q15262 CHOYP_MYSP.3.9 m.2165 sp PTPRK_HUMAN 48.462 130 64 2 1 128 923 1051 4.10E-33 126 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q15262 CHOYP_PTPRK.17.20 m.60780 sp PTPRK_HUMAN 40.659 637 359 8 431 1061 814 1437 4.10E-156 503 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q23157 CHOYP_CRE-INX-11.1.1 m.24184 sp INX11_CAEEL 27.202 386 246 7 5 360 20 400 4.10E-39 149 INX11_CAEEL reviewed Innexin-11 (Protein opu-11) inx-11 opu-11 W04D2.3 Caenorhabditis elegans 465 ion transport [GO:0006811] GO:0005243; GO:0005886; GO:0005921; GO:0006811; GO:0016021; GO:0055077; GO:1903763 0 0 0 PF00876; Q3UPW2 CHOYP_PHUM_PHUM500930.1.1 m.21563 sp ELF3_MOUSE 26.761 355 203 10 75 420 77 383 4.10E-30 123 ELF3_MOUSE reviewed ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) Elf3 Ert Esx Jen Mus musculus (Mouse) 391 "anatomical structure morphogenesis [GO:0009653]; blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000978; GO:0001077; GO:0001824; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005737; GO:0006355; GO:0006954; GO:0009653; GO:0030154; GO:0030198; GO:0030855; GO:0045892; GO:0045893; GO:0045944; GO:0060056 0 0 0 PF00178;PF02198; Q5BJQ7 CHOYP_LOC100374829.1.1 m.7359 sp TADA1_RAT 36.778 329 191 5 10 332 7 324 4.10E-65 212 TADA1_RAT reviewed Transcriptional adapter 1 (Transcriptional adapter 1-like protein) Tada1 Tada1l Rattus norvegicus (Rat) 335 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0070461 0 0 0 PF12767; Q5RJ80 CHOYP_LOC100701854.6.6 m.48494 sp CAPR2_DANRE 28.676 136 86 5 132 264 785 912 4.10E-07 54.3 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5U2U7 CHOYP_MCES.1.2 m.15348 sp MCES_RAT 54.545 352 138 6 44 392 127 459 4.10E-126 375 MCES_RAT reviewed mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) Rnmt Rattus norvegicus (Rat) 461 7-methylguanosine mRNA capping [GO:0006370]; RNA (guanine-N7)-methylation [GO:0036265] GO:0003723; GO:0004482; GO:0005634; GO:0005654; GO:0005730; GO:0005845; GO:0006370; GO:0036265; GO:0043235 0 0 0 PF03291; Q6DGR4 CHOYP_RFC2.1.2 m.12862 sp HGH1_DANRE 45.042 353 190 2 38 390 13 361 4.10E-89 276 HGH1_DANRE reviewed Protein HGH1 homolog hgh1 brp16 fam203a zgc:92803 Danio rerio (Zebrafish) (Brachydanio rerio) 377 0 0 0 0 0 PF04063;PF04064; Q6R653 CHOYP_LOC100377861.1.1 m.36476 sp UN5CL_MOUSE 35.398 452 246 10 179 629 99 505 4.10E-80 266 UN5CL_MOUSE reviewed UNC5C-like protein (Protein unc-5 homolog C-like) (ZU5 and death domain-containing protein) Unc5cl Zud Mus musculus (Mouse) 518 positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330]; signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0008233; GO:0016020; GO:0016021; GO:0043123; GO:0046330 0 0 0 PF00531;PF00791; Q96PZ2 CHOYP_F111A.1.2 m.17271 sp F111A_HUMAN 26.481 287 138 13 363 615 350 597 4.10E-06 53.9 F111A_HUMAN reviewed Protein FAM111A FAM111A KIAA1895 Homo sapiens (Human) 611 defense response to virus [GO:0051607]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071] GO:0000785; GO:0005634; GO:0005737; GO:0006260; GO:0045071; GO:0051607 0 0 0 0 Q9V3U9 CHOYP_SLMO.1.1 m.57991 sp SLMO_DROME 40 135 78 3 4 137 67 199 4.10E-21 88.2 SLMO_DROME reviewed Protein slowmo slmo kisir CG9131 Drosophila melanogaster (Fruit fly) 215 germarium-derived oocyte differentiation [GO:0030706]; larval locomotory behavior [GO:0008345]; multicellular organism development [GO:0007275]; peristalsis [GO:0030432]; spermatogenesis [GO:0007283] GO:0005739; GO:0005758; GO:0007275; GO:0007283; GO:0008345; GO:0030432; GO:0030706; GO:1990050 0 0 0 PF04707; A6QQU6 CHOYP_TM144.2.2 m.52958 sp TM144_BOVIN 48.227 141 64 1 2 133 207 347 4.11E-44 150 TM144_BOVIN reviewed Transmembrane protein 144 TMEM144 Bos taurus (Bovine) 348 0 GO:0016021 0 0 0 PF07857; B3A003 CHOYP_LYS3.1.1 m.31221 sp LYS3_CRAVI 88.235 187 22 0 18 204 1 187 4.11E-121 343 LYS3_CRAVI reviewed "Lysozyme 3 (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase 3) (cv-lysozyme 3)" lysoz3 Crassostrea virginica (Eastern oyster) 187 cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; metabolic process [GO:0008152] GO:0003796; GO:0005576; GO:0008152; GO:0019835; GO:0042742 0 0 0 PF05497; D3KCC4 CHOYP_WHSC1.1.1 m.15309 sp CRNS1_CHICK 32.721 544 340 11 70 594 54 590 4.11E-74 258 CRNS1_CHICK reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 Gallus gallus (Chicken) 930 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 P12074 CHOYP_PHUM_PHUM274850.2.2 m.63552 sp CX6A1_HUMAN 37.647 85 48 3 47 127 23 106 4.11E-09 53.9 CX6A1_HUMAN reviewed "Cytochrome c oxidase subunit 6A1, mitochondrial (Cytochrome c oxidase polypeptide VIa-liver) (Cytochrome c oxidase subunit VIA-liver) (COX VIa-L)" COX6A1 COX6AL Homo sapiens (Human) 109 "generation of precursor metabolites and energy [GO:0006091]; mitochondrial electron transport, cytochrome c to oxygen [GO:0006123]" GO:0004129; GO:0005743; GO:0005751; GO:0006091; GO:0006123 0 0 0 PF02046; P29972 CHOYP_AQP1A.2.1.1 m.56818 sp AQP1_HUMAN 48.536 239 112 3 30 257 3 241 4.11E-66 210 AQP1_HUMAN reviewed Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Urine water channel) (Water channel protein for red blood cells and kidney proximal tubule) AQP1 CHIP28 Homo sapiens (Human) 269 ammonium transport [GO:0015696]; bicarbonate transport [GO:0015701]; carbon dioxide transmembrane transport [GO:0035378]; carbon dioxide transport [GO:0015670]; cellular homeostasis [GO:0019725]; cellular hyperosmotic response [GO:0071474]; cellular response to cAMP [GO:0071320]; cellular response to copper ion [GO:0071280]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to inorganic substance [GO:0071241]; cellular response to mechanical stimulus [GO:0071260]; cellular response to mercury ion [GO:0071288]; cellular response to nitric oxide [GO:0071732]; cellular response to retinoic acid [GO:0071300]; cellular response to salt stress [GO:0071472]; cellular response to stress [GO:0033554]; cellular response to UV [GO:0034644]; cellular water homeostasis [GO:0009992]; cell volume homeostasis [GO:0006884]; cerebrospinal fluid secretion [GO:0033326]; cGMP biosynthetic process [GO:0006182]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; glycerol transport [GO:0015793]; lateral ventricle development [GO:0021670]; maintenance of symbiont-containing vacuole by host [GO:0085018]; multicellular organismal water homeostasis [GO:0050891]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; nitric oxide transport [GO:0030185]; odontogenesis [GO:0042476]; pancreatic juice secretion [GO:0030157]; positive regulation of angiogenesis [GO:0045766]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of saliva secretion [GO:0046878]; potassium ion transport [GO:0006813]; renal water homeostasis [GO:0003091]; renal water transport [GO:0003097]; response to drug [GO:0042493]; transepithelial water transport [GO:0035377]; water transport [GO:0006833] GO:0003091; GO:0003097; GO:0005223; GO:0005267; GO:0005372; GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0005903; GO:0006182; GO:0006813; GO:0006833; GO:0006884; GO:0008519; GO:0009925; GO:0009992; GO:0015079; GO:0015168; GO:0015250; GO:0015254; GO:0015670; GO:0015696; GO:0015701; GO:0015793; GO:0016323; GO:0016324; GO:0019725; GO:0020003; GO:0021670; GO:0022857; GO:0030157; GO:0030184; GO:0030185; GO:0030950; GO:0031526; GO:0031965; GO:0033326; GO:0033554; GO:0034644; GO:0035377; GO:0035378; GO:0035379; GO:0042383; GO:0042476; GO:0042493; GO:0043066; GO:0043154; GO:0045177; GO:0045766; GO:0046878; GO:0048146; GO:0050891; GO:0070062; GO:0070301; GO:0071241; GO:0071260; GO:0071280; GO:0071288; GO:0071300; GO:0071320; GO:0071456; GO:0071472; GO:0071474; GO:0071549; GO:0071732; GO:0085018 0 0 cd00333; PF00230; P41950 CHOYP_SMP_159780.1.2 m.41665 sp DEX1_CAEEL 43.548 62 35 0 933 994 386 447 4.11E-10 69.3 DEX1_CAEEL reviewed Dendrite extension defective protein 1 dex-1 D1044.2 Caenorhabditis elegans 1090 amphid sensory organ dendrite retrograde extension [GO:0003391]; cell-matrix adhesion [GO:0007160] GO:0003391; GO:0005509; GO:0005576; GO:0007160; GO:0016021; GO:0030425; GO:0032590 0 0 0 PF12947;PF06119; Q2KI76 CHOYP_LOC100376740.1.1 m.59181 sp SELS_BOVIN 36.571 175 97 5 50 214 12 182 4.11E-27 105 SELS_BOVIN reviewed Selenoprotein S (SelS) (VCP-interacting membrane protein) VIMP SELS Bos taurus (Bovine) 190 intracellular protein transport [GO:0006886] GO:0005881; GO:0006886; GO:0030176 0 0 0 PF06936; Q38PU3 CHOYP_LOC100533315.1.3 m.40003 sp GRIK2_MACFA 39.231 260 149 5 19 273 600 855 4.11E-50 182 GRIK2_MACFA reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 908 0 GO:0004970; GO:0005234; GO:0016021; GO:0030054; GO:0030424; GO:0043197; GO:0045211 0 0 0 PF01094;PF00060;PF10613; Q3SYS1 CHOYP_LOC661769.1.1 m.10866 sp RM13_BOVIN 47.305 167 88 0 8 174 10 176 4.11E-56 178 RM13_BOVIN reviewed "39S ribosomal protein L13, mitochondrial (L13mt) (MRP-L13)" MRPL13 Bos taurus (Bovine) 178 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0005743; GO:0005761; GO:0005762; GO:0005840; GO:0006412; GO:0070124; GO:0070125 0 0 cd00392; PF00572; Q460N3 CHOYP_PARP14.4.22 m.23514 sp PAR15_HUMAN 29.032 434 239 16 55 446 104 510 4.11E-35 142 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q54HX8 CHOYP_SMP_025370.1.1 m.51107 sp CDIP1_DICDI 42.105 76 44 0 26 101 104 179 4.11E-13 65.1 CDIP1_DICDI reviewed Cell death-inducing p53-target protein 1 homolog (Protein LITAF homolog) litaf DDB_G0289149 Dictyostelium discoideum (Slime mold) 181 0 0 0 0 0 PF10601; Q5U4U6 CHOYP_SYWC.3.5 m.26201 sp T23O_XENLA 39.823 339 187 5 8 330 40 377 4.11E-82 258 T23O_XENLA reviewed "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" tdo2 Xenopus laevis (African clawed frog) 406 tryptophan catabolic process to kynurenine [GO:0019441] GO:0004833; GO:0019441; GO:0020037; GO:0046872 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}. 0 0 PF03301; Q61555 CHOYP_LOC100637925.4.4 m.60117 sp FBN2_MOUSE 30.774 1472 729 67 1374 2686 1378 2718 4.11E-112 405 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q6GL69 CHOYP_CPIPJ_CPIJ007723.3.4 m.30316 sp MK67I_XENTR 45.109 184 96 2 4 187 3 181 4.11E-47 165 MK67I_XENTR reviewed MKI67 FHA domain-interacting nucleolar phosphoprotein-like nifk mki67ipl Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 276 negative regulation of phosphatase activity [GO:0010923] GO:0000166; GO:0003723; GO:0005730; GO:0010923 0 0 0 PF12196;PF00076; Q8IVI9 CHOYP_LOC100903820.1.1 m.38200 sp NOSTN_HUMAN 32.593 135 90 1 47 180 14 148 4.11E-13 70.1 NOSTN_HUMAN reviewed Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) NOSTRIN Homo sapiens (Human) 506 "endocytosis [GO:0006897]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of nitric-oxide synthase activity [GO:0050999]; signal transduction [GO:0007165]" GO:0003677; GO:0005634; GO:0005856; GO:0005886; GO:0006897; GO:0007165; GO:0030666; GO:0045892; GO:0050999 0 0 0 PF00611;PF14604; Q96RW7 CHOYP_TITIN.15.19 m.58193 sp HMCN1_HUMAN 30.208 384 223 14 1 371 951 1302 4.11E-39 152 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9H0R3 CHOYP_TM222.1.1 m.21757 sp TM222_HUMAN 65.854 164 55 1 35 197 41 204 4.11E-81 243 TM222_HUMAN reviewed Transmembrane protein 222 TMEM222 C1orf160 Homo sapiens (Human) 208 0 GO:0016021 0 0 0 PF05608; Q9R013 CHOYP_NEMVEDRAFT_V1G204928.2.2 m.27972 sp CATF_MOUSE 54.817 301 132 3 467 765 164 462 4.11E-108 340 CATF_MOUSE reviewed Cathepsin F (EC 3.4.22.41) Ctsf Mus musculus (Mouse) 462 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0008234; GO:0051603; GO:0070062; GO:1903561 0 0 0 PF08246;PF00112; O70277 CHOYP_BRAFLDRAFT_69798.15.22 m.52699 sp TRIM3_RAT 29.167 120 80 3 35 150 625 743 4.12E-08 55.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P10079 CHOYP_BRAFLDRAFT_63459.1.3 m.27860 sp FBP1_STRPU 35.168 745 419 22 2 703 200 923 4.12E-119 388 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10401 CHOYP_LOC100493088.4.4 m.61886 sp POLY_DROME 24.651 215 136 6 89 298 184 377 4.12E-06 51.6 POLY_DROME reviewed Retrovirus-related Pol polyprotein from transposon gypsy [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1035 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004519; GO:0015074 0 0 0 PF00665;PF00078; P32004 CHOYP_LOC658762.1.2 m.16463 sp L1CAM_HUMAN 24.057 212 142 8 24 227 102 302 4.12E-07 53.5 L1CAM_HUMAN reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) L1CAM CAML1 MIC5 Homo sapiens (Human) 1257 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; leukocyte migration [GO:0050900]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773] GO:0005886; GO:0005925; GO:0006935; GO:0007155; GO:0007399; GO:0007411; GO:0009986; GO:0016021; GO:0044295; GO:0045773; GO:0050900 0 0 0 PF13882;PF00041;PF07679; P44121 CHOYP_LOC100366927.1.1 m.6140 sp DNLI_HAEIN 38.491 265 156 5 206 469 5 263 4.12E-54 186 DNLI_HAEIN reviewed DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]) ligA HI_1182/HI_1183 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 268 DNA ligation involved in DNA repair [GO:0051103]; DNA recombination [GO:0006310]; DNA replication [GO:0006260] GO:0003910; GO:0005524; GO:0006260; GO:0006310; GO:0046872; GO:0051103 0 0 0 PF01068;PF14743; P52735 CHOYP_VAV2.3.3 m.62875 sp VAV2_HUMAN 44.463 587 298 9 193 769 2 570 4.12E-159 489 VAV2_HUMAN reviewed Guanine nucleotide exchange factor VAV2 (VAV-2) VAV2 Homo sapiens (Human) 878 angiogenesis [GO:0001525]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of blood coagulation [GO:0030193]; regulation of cell size [GO:0008361]; regulation of gene expression [GO:0010468]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005085; GO:0005089; GO:0005829; GO:0005886; GO:0007165; GO:0007264; GO:0008361; GO:0010468; GO:0016477; GO:0030032; GO:0030168; GO:0030193; GO:0035023; GO:0038095; GO:0038096; GO:0043065; GO:0043087; GO:0043552; GO:0046872; GO:0048010; GO:0048013; GO:0051056 0 0 0 PF00130;PF11971;PF00169;PF00621;PF00017;PF07653; Q0VD27 CHOYP_ENOPH.3.4 m.51956 sp ENOPH_BOVIN 54.217 249 107 3 20 263 10 256 4.12E-86 262 ENOPH_BOVIN reviewed "Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)" ENOPH1 MASA Bos taurus (Bovine) 261 L-methionine biosynthetic process from methylthioadenosine [GO:0019509] GO:0000287; GO:0005634; GO:0005737; GO:0019509; GO:0043874; GO:0070062 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6. {ECO:0000255|HAMAP-Rule:MF_03117}.; PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6. {ECO:0000255|HAMAP-Rule:MF_03117}. 0 0 0 Q26481 CHOYP_RL5.1.4 m.22292 sp RL5_STYCL 66.667 246 78 3 1 244 51 294 4.12E-115 334 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q4R4I6 CHOYP_LOC100710670.1.2 m.7245 sp CAP1_MACFA 56.034 232 88 3 28 252 250 474 4.12E-83 259 CAP1_MACFA reviewed Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 QtrA-13003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 475 actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902] GO:0000902; GO:0005886; GO:0030036 0 0 0 PF08603;PF01213; Q5F457 CHOYP_LOC100373917.1.1 m.43876 sp WBP4_CHICK 40.476 168 91 2 16 174 1 168 4.12E-28 115 WBP4_CHICK reviewed WW domain-binding protein 4 (WBP-4) WBP4 RCJMB04_3a20 Gallus gallus (Chicken) 398 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0003676; GO:0005681; GO:0006397; GO:0008270; GO:0008380; GO:0016607 0 0 0 PF00397;PF06220; Q5F478 CHOYP_TVAG_020440.2.21 m.3897 sp ANR44_CHICK 33.867 375 247 1 3 376 105 479 4.12E-58 207 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q6DFV8 CHOYP_VWDE.11.13 m.47448 sp VWDE_MOUSE 33.088 136 78 4 36 159 27 161 4.12E-15 83.2 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q6RFZ7 CHOYP_PLEKHG5.2.3 m.37811 sp PKHG5_RAT 36.536 791 406 17 316 1089 7 718 4.12E-139 457 PKHG5_RAT reviewed Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Neuronal RhoA GEF protein) (Transcript highly enriched in cortex and hippocampus) Plekhg5 Tech Rattus norvegicus (Rat) 1039 endothelial cell chemotaxis [GO:0035767]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005737; GO:0005886; GO:0005911; GO:0030027; GO:0030139; GO:0035023; GO:0035767; GO:0048471 0 0 0 PF00621; Q7KVW5 CHOYP_YX11.1.1 m.10251 sp KCNN_DROME 25.783 415 258 9 15 403 457 847 4.12E-37 147 KCNN_DROME reviewed Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) 927 potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057] GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016021; GO:0016057; GO:0016286; GO:0043025 0 0 0 PF02888;PF07885;PF03530; Q8TBZ9 CHOYP_LOC100371304.1.1 m.47915 sp CG062_HUMAN 32.407 216 136 4 70 281 44 253 4.12E-35 130 CG062_HUMAN reviewed Uncharacterized protein C7orf62 C7orf62 Homo sapiens (Human) 253 0 0 0 0 0 0 Q92545 CHOYP_RL23.4.11 m.13923 sp TM131_HUMAN 51.913 183 78 5 35 210 56 235 4.12E-51 180 TM131_HUMAN reviewed Transmembrane protein 131 (Protein RW1) TMEM131 KIAA0257 RW1 Homo sapiens (Human) 1883 0 GO:0016020; GO:0016021 0 0 0 PF12371; Q962X9 CHOYP_BUD31.3.3 m.64519 sp BUD31_BRABE 90.972 144 13 0 1 144 1 144 4.12E-98 281 BUD31_BRABE reviewed Protein BUD31 homolog (Protein G10 homolog) 0 Branchiostoma belcheri (Amphioxus) 144 0 GO:0005634 0 0 0 PF01125; Q96C86 CHOYP_LOC100367637.1.1 m.55661 sp DCPS_HUMAN 48.63 292 143 1 30 314 42 333 4.12E-103 308 DCPS_HUMAN reviewed m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) DCPS DCS1 HINT5 HSPC015 Homo sapiens (Human) 337 "cellular response to menadione [GO:0036245]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; mRNA cis splicing, via spliceosome [GO:0045292]; negative regulation of programmed cell death [GO:0043069]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]" GO:0000288; GO:0000290; GO:0000340; GO:0004532; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0036245; GO:0043069; GO:0043928; GO:0045292; GO:0050072 0 0 0 PF05652; Q9BRZ2 CHOYP_BRAFLDRAFT_91314.1.1 m.28062 sp TRI56_HUMAN 30.952 210 128 6 23 222 18 220 4.12E-18 86.7 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9CZJ2 CHOYP_LOC100223480.4.4 m.58604 sp HS12B_MOUSE 27.969 640 360 19 5 573 58 667 4.12E-65 228 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D9G2 CHOYP_AAEL_AAEL007549.1.1 m.13827 sp PEBP4_MOUSE 41.216 148 78 6 44 188 82 223 4.12E-23 95.5 PEBP4_MOUSE reviewed Phosphatidylethanolamine-binding protein 4 (PEBP-4) Pebp4 Mus musculus (Mouse) 242 0 GO:0005764; GO:0070062 0 0 0 PF01161; Q9ERK0 CHOYP_LOC580708.1.1 m.49052 sp RIPK4_MOUSE 36.111 108 56 5 29 130 514 614 4.12E-09 59.7 RIPK4_MOUSE reviewed Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-associated protein kinase) (PKC-regulated protein kinase) Ripk4 Ankrd3 Pkk Mus musculus (Mouse) 786 morphogenesis of an epithelium [GO:0002009]; positive regulation of NF-kappaB transcription factor activity [GO:0051092] GO:0002009; GO:0004674; GO:0005524; GO:0005737; GO:0016020; GO:0051092 0 0 0 PF12796;PF00069; Q9H0J9 CHOYP_LOC101064698.1.1 m.6866 sp PAR12_HUMAN 49.425 87 43 1 10 96 526 611 4.12E-19 94.4 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9IBG7 CHOYP_CAUR_0430.1.1 m.2917 sp KCP_XENLA 31.724 145 73 3 37 155 408 552 4.12E-08 54.7 KCP_XENLA reviewed Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) 2327 0 GO:0005576 0 0 0 PF00093;PF00094; Q9NUV9 CHOYP_LOC100366813.5.6 m.38572 sp GIMA4_HUMAN 42.149 242 133 3 95 336 28 262 4.12E-57 195 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9W6X3 CHOYP_LOC101416772.1.1 m.30815 sp CH10_ORYLA 72.917 96 26 0 38 133 2 97 4.12E-45 145 CH10_ORYLA reviewed "10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10)" hspe1 hsp10 Oryzias latipes (Japanese rice fish) (Japanese killifish) 99 protein folding [GO:0006457] GO:0005524; GO:0005759; GO:0006457 0 0 cd00320; PF00166; E3TDS3 CHOYP_MTG1.1.1 m.10021 sp MTG1_ICTPU 44.375 320 174 3 14 331 3 320 4.13E-91 278 MTG1_ICTPU reviewed Mitochondrial ribosome-associated GTPase 1 (Mitochondrial GTPase 1) mtg1 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 320 regulation of translation [GO:0006417] GO:0005525; GO:0005743; GO:0005759; GO:0005761; GO:0006417 0 0 0 PF01926; O14522 CHOYP_ISCW_ISCW009628.1.1 m.31923 sp PTPRT_HUMAN 43.478 184 101 2 134 316 869 1050 4.13E-41 155 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O75832 CHOYP_YL122.2.2 m.58061 sp PSD10_HUMAN 28.723 188 113 7 65 246 39 211 4.13E-09 60.1 PSD10_HUMAN reviewed 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 Homo sapiens (Human) 226 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteasome regulatory particle assembly [GO:0070682]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000122; GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005838; GO:0006521; GO:0006915; GO:0007253; GO:0008134; GO:0030307; GO:0031145; GO:0031398; GO:0032088; GO:0032436; GO:0033209; GO:0038061; GO:0038095; GO:0043066; GO:0043161; GO:0043409; GO:0043488; GO:0043518; GO:0045111; GO:0045737; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070682; GO:0090090; GO:0090201; GO:0090263 0 0 0 PF00023;PF12796; O95714 CHOYP_LOC100370069.3.14 m.33282 sp HERC2_HUMAN 28.889 180 89 7 8 153 1758 1932 4.13E-08 59.3 HERC2_HUMAN reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; intracellular protein transport [GO:0006886]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005743; GO:0005814; GO:0006303; GO:0006886; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016925; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; P0C218 CHOYP_DDX20.1.3 m.11391 sp DDX20_DANRE 59.483 116 47 0 25 140 293 408 4.13E-37 150 DDX20_DANRE reviewed Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (DEAD box protein 20) ddx20 Danio rerio (Zebrafish) (Brachydanio rerio) 761 RNA secondary structure unwinding [GO:0010501]; spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0003677; GO:0004004; GO:0005524; GO:0005634; GO:0005829; GO:0010501; GO:0032797; GO:0034719 0 0 0 PF00270;PF00271; P19351 CHOYP_SMP_179810.3.3 m.50458 sp TNNT_DROME 41.87 246 128 6 40 282 52 285 4.13E-31 122 TNNT_DROME reviewed "Troponin T, skeletal muscle (Protein intended thorax) (Protein upheld)" up int CG7107 Drosophila melanogaster (Fruit fly) 397 cellular calcium ion homeostasis [GO:0006874]; mesoderm development [GO:0007498]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; muscle organ morphogenesis [GO:0048644]; myofibril assembly [GO:0030239]; regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214]; skeletal muscle thin filament assembly [GO:0030240] GO:0005509; GO:0005861; GO:0005865; GO:0006874; GO:0006937; GO:0007005; GO:0007498; GO:0030239; GO:0030240; GO:0045214; GO:0046716; GO:0048644 0 0 0 PF00992; P20273 CHOYP_LOC100880815.1.7 m.15880 sp CD22_HUMAN 23.173 479 313 16 87 535 150 603 4.13E-20 99.8 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; Q14106 CHOYP_RL3.4.7 m.41933 sp TOB2_HUMAN 50.661 227 76 6 1 226 1 192 4.13E-62 206 TOB2_HUMAN reviewed Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2) TOB2 KIAA1663 TOB4 TROB2 Homo sapiens (Human) 344 female gamete generation [GO:0007292]; negative regulation of cell proliferation [GO:0008285]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of ossification [GO:0045778]; regulation of gene expression [GO:0010468] GO:0005634; GO:0005737; GO:0007292; GO:0008285; GO:0010468; GO:0045671; GO:0045778 0 0 0 PF07742;PF07145; Q15070 CHOYP_LOC100117732.1.1 m.18587 sp OXA1L_HUMAN 33.119 311 199 3 113 420 107 411 4.13E-53 186 OXA1L_HUMAN reviewed Mitochondrial inner membrane protein OXA1L (Hsa) (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein) OXA1L Homo sapiens (Human) 435 aerobic respiration [GO:0009060]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]; mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex I biogenesis [GO:0097031]; negative regulation of ATPase activity [GO:0032780]; negative regulation of oxidoreductase activity [GO:0051354]; oxidation-reduction process [GO:0055114]; protein complex assembly [GO:0006461]; protein insertion into membrane [GO:0051205]; protein tetramerization [GO:0051262] GO:0005739; GO:0005746; GO:0006461; GO:0009060; GO:0031966; GO:0032592; GO:0032780; GO:0032981; GO:0033615; GO:0042803; GO:0043234; GO:0051205; GO:0051262; GO:0051354; GO:0055114; GO:0097031; GO:0097177 0 0 0 PF02096; Q26474 CHOYP_LOC100168017.1.1 m.40316 sp LACH_SCHAM 28.824 340 224 10 25 357 19 347 4.13E-33 129 LACH_SCHAM reviewed Lachesin LAC Schistocerca americana (American grasshopper) 349 cell adhesion [GO:0007155]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005886; GO:0007155; GO:0007169; GO:0031225 0 0 0 PF07679; Q5R4Q3 CHOYP_SEC62.1.3 m.11256 sp SEC62_PONAB 39.37 381 197 6 85 443 8 376 4.13E-69 228 SEC62_PONAB reviewed Translocation protein SEC62 (Translocation protein 1) (TP-1) SEC62 TLOC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 399 posttranslational protein targeting to membrane [GO:0006620] GO:0005789; GO:0005791; GO:0006620; GO:0008565; GO:0016021; GO:0016235; GO:0045111 0 0 0 PF03839; Q5ZM20 CHOYP_BRAFLDRAFT_128304.1.1 m.18675 sp RMI2_CHICK 29.204 113 76 2 39 147 17 129 4.13E-10 57.8 RMI2_CHICK reviewed RecQ-mediated genome instability protein 2 RMI2 RCJMB04_3g8 Gallus gallus (Chicken) 137 DNA replication [GO:0006260] GO:0003677; GO:0005634; GO:0005737; GO:0006260 0 0 0 PF16100; Q6GQ69 CHOYP_FAF2.1.1 m.54272 sp FAF2B_XENLA 47.343 207 93 4 1 199 243 441 4.13E-52 176 FAF2B_XENLA reviewed FAS-associated factor 2-B (UBX domain-containing protein 8-B) faf2-b ubxd8-b Xenopus laevis (African clawed frog) 445 0 GO:0005783; GO:0005811 0 0 0 PF00789; Q6NRM1 CHOYP_BRAFLDRAFT_210496.1.1 m.56416 sp S399B_XENLA 56.508 315 122 5 1 312 1 303 4.13E-114 335 S399B_XENLA reviewed Zinc transporter ZIP9-B (Solute carrier family 39 member 9-B) (Zrt- and Irt-like protein 9-B) (ZIP-9-B) slc39a9-b zip9-b Xenopus laevis (African clawed frog) 303 zinc II ion transport [GO:0006829] GO:0006829; GO:0016021; GO:0046873 0 0 0 PF02535; Q6P9V9 CHOYP_LOC100366892.2.3 m.51425 sp TBA1B_RAT 95.928 221 8 1 1 221 1 220 4.13E-157 445 TBA1B_RAT reviewed Tubulin alpha-1B chain (Alpha-tubulin 2) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] Tuba1b Tuba2 Rattus norvegicus (Rat) 451 cellular response to interleukin-4 [GO:0071353]; microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0003725; GO:0003924; GO:0005200; GO:0005525; GO:0005881; GO:0043209; GO:0070062; GO:0071353 0 0 0 PF00091;PF03953; Q6S9C8 CHOYP_LTA4H.1.1 m.49386 sp LKHA4_CHILA 53.973 365 164 3 18 381 17 378 4.13E-141 417 LKHA4_CHILA reviewed Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) 611 leukotriene biosynthetic process [GO:0019370]; peptide catabolic process [GO:0043171] GO:0004177; GO:0004301; GO:0004463; GO:0005737; GO:0008237; GO:0008270; GO:0019370; GO:0043171 PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. 0 0 PF09127;PF01433; Q76NI1 CHOYP_BRAFLDRAFT_124240.1.1 m.8573 sp VKIND_HUMAN 33.483 666 391 19 1496 2131 1106 1749 4.13E-92 337 VKIND_HUMAN reviewed Protein very KIND (Cerebral protein 9) (KIND domain-containing protein 1) (Kinase non-catalytic C-lobe domain-containing protein 1) (Ras-GEF domain-containing family member 2) KNDC1 C10orf23 KIAA1768 RASGEF2 VKIND hucep-9 Homo sapiens (Human) 1749 cerebellar granule cell differentiation [GO:0021707]; positive regulation of protein phosphorylation [GO:0001934]; regulation of dendrite morphogenesis [GO:0048814]; small GTPase mediated signal transduction [GO:0007264] GO:0001934; GO:0005088; GO:0007264; GO:0021707; GO:0030425; GO:0032045; GO:0043025; GO:0048814 0 0 cd06224; PF16474;PF00617;PF00618; Q8R5F7 CHOYP_DDX58.3.9 m.7621 sp IFIH1_MOUSE 26.923 234 115 8 72 251 117 348 4.13E-13 72 IFIH1_MOUSE reviewed Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Helicase with 2 CARD domains) (Helicard) (Interferon induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (RIG-I-like receptor 2) (RLR-2) Ifih1 Mus musculus (Mouse) 1025 innate immune response [GO:0045087]; MDA-5 signaling pathway [GO:0039530]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; protein sumoylation [GO:0016925]; response to virus [GO:0009615] GO:0003677; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005634; GO:0005737; GO:0008270; GO:0009615; GO:0016925; GO:0032727; GO:0032728; GO:0039530; GO:0043021; GO:0045087 0 0 0 PF16739;PF00271;PF04851;PF11648; Q98925 CHOYP_LOC100883420.1.1 m.61906 sp IRF2_CHICK 51.351 74 35 1 19 91 2 75 4.13E-20 85.9 IRF2_CHICK reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) 348 cell proliferation [GO:0008283] GO:0000977; GO:0001228; GO:0005654; GO:0005737; GO:0005925; GO:0008283 0 0 0 PF00605; Q9ES88 CHOYP_S13A2.2.2 m.62232 sp S13A2_MOUSE 43.281 573 294 10 9 564 6 564 4.13E-135 409 S13A2_MOUSE reviewed Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) Slc13a2 Nadc1 Sdct1 Mus musculus (Mouse) 586 0 GO:0005887; GO:0015361; GO:0070062 0 0 0 PF00939; Q9ESN6 CHOYP_BRAFLDRAFT_102380.10.11 m.64690 sp TRIM2_MOUSE 29.146 199 122 7 169 360 521 707 4.13E-14 77 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC100374741.73.83 m.60198 sp TRIM2_MOUSE 27.184 206 136 6 324 523 534 731 4.13E-13 75.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9Z1L8 CHOYP_LOC100555060.1.1 m.35340 sp MDS1_MOUSE 53.333 60 25 2 72 129 69 127 4.13E-14 67.8 MDS1_MOUSE reviewed MDS1 and EVI1 complex locus protein MDS1 (Myelodysplasia syndrome 1 protein homolog) Mecom Mds1 Mus musculus (Mouse) 129 "embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; forebrain development [GO:0030900]; inflammatory response [GO:0006954]; in utero embryonic development [GO:0001701]; maintenance of cell number [GO:0098727]; negative regulation of JNK cascade [GO:0046329]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription, DNA-templated [GO:0045892]; neutrophil homeostasis [GO:0001780]; pericardium development [GO:0060039]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; regulation of cell cycle [GO:0051726]; regulation of cell proliferation [GO:0042127]; renal system development [GO:0072001]; response to bacterium [GO:0009617]" GO:0001701; GO:0001780; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0006954; GO:0009617; GO:0009791; GO:0016235; GO:0016607; GO:0030900; GO:0035115; GO:0035116; GO:0042127; GO:0043069; GO:0043231; GO:0045892; GO:0045893; GO:0045944; GO:0046329; GO:0051726; GO:0060039; GO:0072001; GO:0090336; GO:0098727 0 0 0 0 A7SM54 CHOYP_UFC1.1.2 m.6917 sp UFC1_NEMVE 86.31 168 23 0 25 192 1 168 4.14E-109 312 UFC1_NEMVE reviewed Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) v1g214407 Nematostella vectensis (Starlet sea anemone) 169 0 0 0 0 0 PF08694; F6QEU4 CHOYP_LOC100378898.5.10 m.45396 sp LIN41_XENTR 20.508 551 341 17 6 517 141 633 4.14E-09 63.2 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O70277 CHOYP_BRAFLDRAFT_88219.1.5 m.37187 sp TRIM3_RAT 24.138 261 181 6 317 567 489 742 4.14E-14 79 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O95801 CHOYP_TTC4.1.1 m.16365 sp TTC4_HUMAN 44.304 316 166 3 127 435 71 383 4.14E-88 276 TTC4_HUMAN reviewed Tetratricopeptide repeat protein 4 (TPR repeat protein 4) TTC4 My044 Homo sapiens (Human) 387 0 0 0 0 0 0 P02362 CHOYP_RS7.7.9 m.50357 sp RS7_XENLA 85.294 102 14 1 1 101 93 194 4.14E-58 179 RS7_XENLA reviewed 40S ribosomal protein S7 (40S ribosomal protein S8) rps7 rps8 Xenopus laevis (African clawed frog) 194 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01251; P49165 CHOYP_RL4.4.6 m.37116 sp RL4_URECA 58.252 103 35 3 1 100 283 380 4.14E-22 91.7 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; P53563 CHOYP_LOC585734.1.1 m.36212 sp B2CL1_RAT 31.776 107 62 4 392 489 89 193 4.14E-06 51.6 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; Q1L987 CHOYP_CPIPJ_CPIJ017568.1.1 m.43882 sp ATPF1_DANRE 34.94 249 141 3 75 314 51 287 4.14E-51 174 ATPF1_DANRE reviewed ATP synthase mitochondrial F1 complex assembly factor 1 atpaf1 si:dkey-171o17.2 zgc:110583 Danio rerio (Zebrafish) (Brachydanio rerio) 302 mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] GO:0005739; GO:0033615 0 0 0 PF06644; Q28C65 CHOYP_EIF3K.1.1 m.59650 sp EIF3K_XENTR 62.5 208 78 0 3 210 5 212 4.14E-96 282 EIF3K_XENTR reviewed Eukaryotic translation initiation factor 3 subunit K (eIF3k) (Eukaryotic translation initiation factor 3 subunit 12) (eIF-3 p25) eif3k eif3s12 TTpA007f24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 218 formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413] GO:0001731; GO:0003743; GO:0005634; GO:0005852; GO:0006413; GO:0006446; GO:0016282; GO:0033290; GO:0043022 0 0 0 PF10075; Q4J9D2 CHOYP_LOC100928016.3.6 m.37803 sp Y1252_SULAC 34.857 175 99 5 184 353 11 175 4.14E-21 94.7 Y1252_SULAC reviewed Uncharacterized protein Saci_1252 Saci_1252 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 181 0 0 0 0 0 PF01661; Q4LDE5 CHOYP_LOC100367084.17.22 m.55670 sp SVEP1_HUMAN 22.934 702 417 28 204 826 434 1090 4.14E-32 141 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5EB30 CHOYP_LOC100207216.2.2 m.28185 sp ODF3A_XENTR 39.256 242 144 3 8 247 11 251 4.14E-46 157 ODF3A_XENTR reviewed Outer dense fiber protein 3 (Outer dense fiber of sperm tails protein 3) odf3 TTpA001k06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 256 0 GO:0005737 0 0 0 PF07004; Q5UR67 CHOYP_contig_019890 m.23156 sp RIBX_MIMIV 50.549 91 45 0 1 91 76 166 4.14E-22 89.4 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q6EDY6 CHOYP_LR16A.1.3 m.9037 sp CARL1_MOUSE 35.915 1033 517 25 1 986 249 1183 4.14E-178 569 CARL1_MOUSE reviewed "F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (CARML1) (Leucine-rich repeat-containing protein 16A)" Lrrc16a Carmil Lrrc16 Mus musculus (Mouse) 1374 actin filament network formation [GO:0051639]; barbed-end actin filament uncapping [GO:0051638]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; lamellipodium assembly [GO:0030032]; macropinocytosis [GO:0044351]; negative regulation of barbed-end actin filament capping [GO:2000813]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of lamellipodium organization [GO:1902745]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; ruffle organization [GO:0031529]; urate metabolic process [GO:0046415] GO:0005634; GO:0005737; GO:0005886; GO:0007163; GO:0016477; GO:0030027; GO:0030032; GO:0030335; GO:0030838; GO:0031252; GO:0031529; GO:0031941; GO:0032403; GO:0044351; GO:0044354; GO:0045111; GO:0046415; GO:0051496; GO:0051638; GO:0051639; GO:0070062; GO:1900026; GO:1902745; GO:2000813 0 0 0 PF16000;PF13516; Q6GLZ8 CHOYP_PHUM_PHUM335250.1.2 m.20766 sp SNR27_XENLA 50 92 44 2 80 170 68 158 4.14E-25 97.8 SNR27_XENLA reviewed U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (U4/U6.U5 tri-snRNP-associated protein 3) snrnp27 Xenopus laevis (African clawed frog) 158 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005634; GO:0006397; GO:0008380 0 0 0 PF08648; Q6IA69 CHOYP_LOC585494.1.1 m.64159 sp NADE_HUMAN 70.588 153 45 0 1 153 1 153 4.14E-75 239 NADE_HUMAN reviewed Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase) NADSYN1 Homo sapiens (Human) 706 NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674] GO:0003952; GO:0004359; GO:0005524; GO:0005737; GO:0005829; GO:0009435; GO:0019674 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1. 0 cd00553; PF00795;PF02540; Q791B0 CHOYP_UBL5.3.5 m.41673 sp UBL5_PSAOB 87.671 73 9 0 33 105 1 73 4.14E-43 138 UBL5_PSAOB reviewed Ubiquitin-like protein 5 (Beacon protein) UBL5 Psammomys obesus (Fat sand rat) 73 0 GO:0005737 0 0 0 PF00240; Q80TY5 CHOYP_VPS13B.1.1 m.45681 sp VP13B_MOUSE 30.565 301 165 8 13 275 333 627 4.14E-28 122 VP13B_MOUSE reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1 homolog) Vps13b Coh1 Kiaa0532 Mus musculus (Mouse) 4013 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q80WC9 CHOYP_ACSF4.1.1 m.62580 sp ACSF4_MOUSE 42.727 330 173 6 71 393 191 511 4.14E-81 272 ACSF4_MOUSE reviewed Acyl-CoA synthetase family member 4 (EC 6.2.1.-) (2-aminoadipic 6-semialdehyde dehydrogenase) (Protein LYS2 homolog) (Putative aminoadipate-semialdehyde dehydrogenase) (EC 1.2.1.31) Aasdh Acsf4 U26 Mus musculus (Mouse) 1100 amino acid activation for nonribosomal peptide biosynthetic process [GO:0043041]; beta-alanine metabolic process [GO:0019482]; fatty acid metabolic process [GO:0006631] GO:0004043; GO:0005524; GO:0006631; GO:0016878; GO:0019482; GO:0043041 0 0 0 PF00501;PF00550;PF13360;PF13570; Q9BSV6 CHOYP_BRAFLDRAFT_239658.1.1 m.64536 sp SEN34_HUMAN 36.601 306 167 4 12 290 4 309 4.14E-59 194 SEN34_HUMAN reviewed tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) TSEN34 LENG5 SEN34 Homo sapiens (Human) 310 "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]" GO:0000213; GO:0000214; GO:0000379; GO:0003676; GO:0005634; GO:0005654; GO:0005730; GO:0006388; GO:0006397; GO:0016829 0 0 0 PF01974; Q9CZJ2 CHOYP_HS12B.3.14 m.29598 sp HS12B_MOUSE 37.624 202 78 4 43 196 195 396 4.14E-32 125 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9GNE2 CHOYP_RPL23.1.3 m.2028 sp RL23_AEDAE 86.957 92 12 0 14 105 1 92 4.14E-51 160 RL23_AEDAE reviewed 60S ribosomal protein L23 (AeRpL17A) (L17A) RpL23-A RpL17A AAEL013097; RpL23-B AAEL013583; RpL23-C AAEL015006 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 140 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00238; Q9H490 CHOYP_LOC581221.1.1 m.9986 sp PIGU_HUMAN 42.654 422 233 4 20 438 20 435 4.14E-122 365 PIGU_HUMAN reviewed Phosphatidylinositol glycan anchor biosynthesis class U protein (Cell division cycle protein 91-like 1) (Protein CDC91-like 1) (GPI transamidase component PIG-U) PIGU CDC91L1 PSEC0205 UNQ3055/PRO9875 Homo sapiens (Human) 435 attachment of GPI anchor to protein [GO:0016255]; GPI anchor biosynthetic process [GO:0006506]; regulation of JAK-STAT cascade [GO:0046425] GO:0005789; GO:0005886; GO:0006506; GO:0016020; GO:0016255; GO:0030176; GO:0042765; GO:0046425 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF06728; G5ED84 CHOYP_BACH1.4.17 m.8088 sp KLHL8_CAEEL 27.536 138 92 4 7 137 88 224 4.15E-07 57.4 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O42097 CHOYP_FKH.1.1 m.33174 sp FOXA2_ORYLA 47.25 400 162 16 39 411 27 404 4.15E-90 281 FOXA2_ORYLA reviewed Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) (Me-HNF3B) foxa2 hnf3b Oryzias latipes (Japanese rice fish) (Japanese killifish) 415 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565 0 0 0 PF00250;PF08430;PF09354; P10079 CHOYP_LOC100634060.12.37 m.34459 sp FBP1_STRPU 53.073 179 84 0 1 179 324 502 4.15E-50 176 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P12812 CHOYP_contig_040623 m.46145 sp P40_SCHMA 31.034 87 60 0 140 226 132 218 4.15E-06 50.1 P40_SCHMA reviewed Major egg antigen (p40) 0 Schistosoma mansoni (Blood fluke) 354 0 0 0 0 0 PF00011; P29218 CHOYP_LOC100891888.1.1 m.20756 sp IMPA1_HUMAN 48.905 274 139 1 1 273 1 274 4.15E-93 279 IMPA1_HUMAN reviewed Inositol monophosphatase 1 (IMP 1) (IMPase 1) (EC 3.1.3.25) (D-galactose 1-phosphate phosphatase) (EC 3.1.3.94) (Inositol-1(or 4)-monophosphatase 1) (Lithium-sensitive myo-inositol monophosphatase A1) IMPA1 IMPA Homo sapiens (Human) 277 inositol biosynthetic process [GO:0006021]; inositol metabolic process [GO:0006020]; inositol phosphate dephosphorylation [GO:0046855]; inositol phosphate metabolic process [GO:0043647]; phosphate-containing compound metabolic process [GO:0006796]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphorylation [GO:0046854]; signal transduction [GO:0007165] GO:0000287; GO:0005737; GO:0005829; GO:0006020; GO:0006021; GO:0006661; GO:0006796; GO:0007165; GO:0008934; GO:0030145; GO:0031403; GO:0042802; GO:0042803; GO:0043647; GO:0046854; GO:0046855; GO:0052832; GO:0052833; GO:0052834; GO:0070062 PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2. 0 0 PF00459; P74897 CHOYP_NEMVEDRAFT_V1G114289.1.1 m.17188 sp YQA3_THEAQ 27.703 148 89 4 6 150 3 135 4.15E-07 49.7 YQA3_THEAQ reviewed Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) 0 Thermus aquaticus 137 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q08AW4 CHOYP_PKHM1.1.1 m.35838 sp PKHM3_XENLA 46.218 238 128 0 711 948 484 721 4.15E-72 257 PKHM3_XENLA reviewed Pleckstrin homology domain-containing family M member 3 (PH domain-containing family M member 3) plekhm3 Xenopus laevis (African clawed frog) 748 0 GO:0046872 0 0 0 PF00169;PF13901; Q12955 CHOYP_LOC578974.3.11 m.21048 sp ANK3_HUMAN 39.831 118 71 0 5 122 61 178 4.15E-25 102 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q2F637 CHOYP_14332.2.2 m.61737 sp 1433Z_BOMMO 67.331 251 78 1 1 251 1 247 4.15E-119 342 1433Z_BOMMO reviewed 14-3-3 protein zeta 14-3-3zeta Bombyx mori (Silk moth) 247 0 GO:0005737 0 0 0 PF00244; Q2F637 CHOYP_PCDH7.3.3 m.56227 sp 1433Z_BOMMO 67.331 251 78 1 1 251 1 247 4.15E-119 342 1433Z_BOMMO reviewed 14-3-3 protein zeta 14-3-3zeta Bombyx mori (Silk moth) 247 0 GO:0005737 0 0 0 PF00244; Q5ZJV7 CHOYP_LOC100371590.1.1 m.64406 sp FA60A_CHICK 49.772 219 90 3 1 213 1 205 4.15E-64 202 FA60A_CHICK reviewed Protein FAM60A FAM60A RCJMB04_15g2 Gallus gallus (Chicken) 222 negative regulation of cell migration [GO:0030336] GO:0016580; GO:0030336 0 0 0 PF15396; Q6XIM8 CHOYP_RS15A.5.11 m.18785 sp RS15A_DROYA 82.014 139 16 1 6 144 1 130 4.15E-81 237 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q8CIG9 CHOYP_LOC100369570.1.1 m.25302 sp FBXL8_MOUSE 29.024 379 251 6 16 392 6 368 4.15E-41 152 FBXL8_MOUSE reviewed F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8) Fbxl8 Fbl8 Mus musculus (Mouse) 374 0 GO:0004842 0 0 0 PF12937; Q8IWZ3 CHOYP_LOC100641729.2.10 m.13163 sp ANKH1_HUMAN 31.962 316 200 9 1 303 279 592 4.15E-30 124 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8VCX6 CHOYP_PNO1.2.3 m.47801 sp KPTN_MOUSE 40.056 357 178 7 12 366 17 339 4.15E-75 246 KPTN_MOUSE reviewed Kaptin Kptn Mus musculus (Mouse) 430 actin filament organization [GO:0007015] GO:0007015; GO:0015629; GO:0030426; GO:0032420; GO:0048471 0 0 0 0 Q96DM1 CHOYP_PGBD4.2.2 m.21975 sp PGBD4_HUMAN 28.159 554 347 18 28 547 35 571 4.15E-45 171 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9D572 CHOYP_BRAFLDRAFT_225147.1.1 m.43122 sp UBX11_MOUSE 35.714 294 154 8 1 291 195 456 4.15E-47 173 UBX11_MOUSE reviewed UBX domain-containing protein 11 (Socius) (UBX domain-containing protein 5) Ubxn11 D4Bwg1540e Soc Ubxd5 Mus musculus (Mouse) 484 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0005737; GO:0005856; GO:0043130; GO:0043161 0 0 0 PF08059;PF00789; Q9FJJ3 CHOYP_LOC100369444.1.1 m.18613 sp SRO5_ARATH 37.815 119 51 5 592 699 120 226 4.15E-07 55.8 SRO5_ARATH reviewed Probable inactive poly [ADP-ribose] polymerase SRO5 (Protein SIMILAR TO RCD ONE 5) SRO5 At5g62520 K19B1.13 Arabidopsis thaliana (Mouse-ear cress) 309 multicellular organism development [GO:0007275]; reactive oxygen species metabolic process [GO:0072593]; response to salt stress [GO:0009651] GO:0003950; GO:0005739; GO:0007275; GO:0009651; GO:0016363; GO:0072593 0 0 0 PF12174; Q9JLC8 CHOYP_SACS.16.17 m.65683 sp SACS_MOUSE 25.168 298 185 12 1 273 537 821 4.15E-13 72.8 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9JLV2 CHOYP_LOC101163318.1.1 m.14547 sp TP4AP_MOUSE 39.231 780 426 17 14 768 36 792 4.15E-168 507 TP4AP_MOUSE reviewed Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (Rabex-5/Rin2-interacting protein) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS) Trpc4ap Trrp4ap Mus musculus (Mouse) 797 protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016567; GO:0019902; GO:0031464 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12463; Q9Y2F9 CHOYP_AAEL_AAEL014192.1.1 m.26911 sp BTBD3_HUMAN 39.735 151 86 2 9 154 98 248 4.15E-26 106 BTBD3_HUMAN reviewed BTB/POZ domain-containing protein 3 BTBD3 KIAA0952 Homo sapiens (Human) 522 cerebral cortex development [GO:0021987]; dendrite morphogenesis [GO:0048813]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of proteolysis [GO:0030162] GO:0005634; GO:0005829; GO:0019005; GO:0021987; GO:0030162; GO:0031625; GO:0042787; GO:0043161; GO:0048813 0 0 0 PF07707;PF00651;PF08005; A7E3C4 CHOYP_LOC614821.1.1 m.49662 sp F187A_BOVIN 25.538 325 202 13 138 453 98 391 4.16E-15 80.5 F187A_BOVIN reviewed Ig-like V-type domain-containing protein FAM187A FAM187A Bos taurus (Bovine) 421 0 GO:0016021 0 0 0 PF07686; B0UZC8 CHOYP_VWCE.2.3 m.19263 sp VWC2L_DANRE 39.08 87 50 3 44 129 116 200 4.16E-09 56.2 VWC2L_DANRE reviewed von Willebrand factor C domain-containing protein 2-like vwc2l si:ch211-207d8.1 Danio rerio (Zebrafish) (Brachydanio rerio) 223 nervous system development [GO:0007399] GO:0005576; GO:0007399; GO:0030054; GO:0045202 0 0 0 PF00093; O15226 CHOYP_NKRF.1.1 m.61828 sp NKRF_HUMAN 36.122 263 151 9 374 632 438 687 4.16E-34 141 NKRF_HUMAN reviewed NF-kappa-B-repressing factor (NFkB-repressing factor) (Protein ITBA4) (Transcription factor NRF) NKRF ITBA4 NRF Homo sapiens (Human) 690 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005730; GO:0005783; GO:0006351; GO:0044822; GO:0045892 0 0 0 PF01585;PF01424; P02552 CHOYP_LOC100533261.1.1 m.36144 sp TBA1_CHICK 70.149 134 22 5 1 127 164 286 4.16E-53 176 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P10079 CHOYP_LOC100632098.1.13 m.4036 sp FBP1_STRPU 50.781 384 189 0 151 534 211 594 4.16E-117 380 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P47911 CHOYP_BRAFLDRAFT_114734.2.8 m.11631 sp RL6_MOUSE 63.5 200 69 2 62 260 100 296 4.16E-80 246 RL6_MOUSE reviewed 60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) Rpl6 Mus musculus (Mouse) 296 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; P54316 CHOYP_BRAFLDRAFT_126555.2.6 m.5075 sp LIPR1_RAT 34.483 464 277 11 28 480 5 452 4.16E-91 288 LIPR1_RAT reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) Pnliprp1 Plrp1 Rattus norvegicus (Rat) 473 lipid metabolic process [GO:0006629]; pancreas development [GO:0031016]; response to glucocorticoid [GO:0051384]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005509; GO:0005615; GO:0006629; GO:0016298; GO:0031016; GO:0043434; GO:0051384 0 0 0 PF00151;PF01477; P56470 CHOYP_LGALS4.1.2 m.25332 sp LEG4_HUMAN 41.237 97 53 4 39 132 221 316 4.16E-12 66.2 LEG4_HUMAN reviewed Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4) LGALS4 Homo sapiens (Human) 323 cell adhesion [GO:0007155] GO:0005615; GO:0005829; GO:0005886; GO:0007155; GO:0016936; GO:0030246 0 0 0 PF00337; Q0E908 CHOYP_SMP_051990.5.7 m.43424 sp HIL_DROME 27.823 496 307 9 17 468 330 818 4.16E-53 204 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q12955 CHOYP_LOC100635111.8.13 m.39854 sp ANK3_HUMAN 33.144 353 231 2 367 719 110 457 4.16E-57 215 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q24K03 CHOYP_THUM1.1.1 m.47876 sp THUM1_BOVIN 43.396 265 135 7 34 291 14 270 4.16E-68 222 THUM1_BOVIN reviewed THUMP domain-containing protein 1 THUMPD1 Bos taurus (Bovine) 357 0 GO:0044822 0 0 0 PF02926; Q3U2J5 CHOYP_LOC100892111.1.1 m.35231 sp CMKMT_MOUSE 47.982 223 114 2 1 221 101 323 4.16E-76 235 CMKMT_MOUSE reviewed Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) Camkmt Clnmt Mus musculus (Mouse) 323 mitochondrion organization [GO:0007005]; peptidyl-lysine methylation [GO:0018022] GO:0005634; GO:0005794; GO:0007005; GO:0018022; GO:0018025 0 0 0 PF10294; Q502M6 CHOYP_TVAG_020440.21.21 m.61129 sp ANR29_DANRE 38.426 216 131 1 4 219 55 268 4.16E-40 142 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q52KB6 CHOYP_LOC576341.2.2 m.16556 sp C2CD3_MOUSE 26.05 952 489 30 1 927 96 857 4.16E-67 249 C2CD3_MOUSE reviewed C2 domain-containing protein 3 (Protein hearty) C2cd3 Hty Mus musculus (Mouse) 2323 brain development [GO:0007420]; centriole elongation [GO:0061511]; cilium assembly [GO:0042384]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; nonmotile primary cilium assembly [GO:0035058]; pattern specification process [GO:0007389]; protein localization to centrosome [GO:0071539]; protein processing [GO:0016485]; regulation of proteolysis [GO:0030162]; regulation of smoothened signaling pathway [GO:0008589] GO:0001701; GO:0001947; GO:0005813; GO:0005814; GO:0007389; GO:0007420; GO:0008589; GO:0016485; GO:0021915; GO:0021997; GO:0030162; GO:0030326; GO:0034451; GO:0035058; GO:0036064; GO:0042384; GO:0042733; GO:0061511; GO:0071539 0 0 0 PF00168; Q5ZJL9 CHOYP_SAMH1.4.12 m.21842 sp SAMH1_CHICK 53.333 105 38 4 1 104 207 301 4.16E-25 100 SAMH1_CHICK reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) 614 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966; Q60787 CHOYP_LCP2.5.14 m.16512 sp LCP2_MOUSE 36.296 135 83 2 493 624 389 523 4.16E-19 94.7 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q6DJN2 CHOYP_LOC584052.1.1 m.6375 sp TRF6B_XENLA 36.975 238 139 8 13 249 52 279 4.16E-40 149 TRF6B_XENLA reviewed TNF receptor-associated factor 6-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6-b Xenopus laevis (African clawed frog) 556 activation of NF-kappaB-inducing kinase activity [GO:0007250]; immune response [GO:0006955]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981] GO:0004842; GO:0005737; GO:0006955; GO:0007250; GO:0008270; GO:0016874; GO:0042981; GO:0070534 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02176; Q86TI4 CHOYP_LOC100373850.1.1 m.59419 sp WDR86_HUMAN 43.288 365 188 3 1 365 1 346 4.16E-102 310 WDR86_HUMAN reviewed WD repeat-containing protein 86 WDR86 Homo sapiens (Human) 376 0 0 0 0 0 PF00400; Q98943 CHOYP_LOC100638885.4.4 m.61424 sp CASP2_CHICK 33.333 264 155 7 276 526 163 418 4.16E-35 139 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9BV44 CHOYP_THUM3.1.1 m.17928 sp THUM3_HUMAN 36.292 507 255 9 16 511 40 489 4.16E-93 296 THUM3_HUMAN reviewed THUMP domain-containing protein 3 THUMPD3 Homo sapiens (Human) 507 tRNA methylation [GO:0030488] GO:0000049; GO:0005730; GO:0005737; GO:0016423; GO:0030488 0 0 0 PF02926;PF01170; Q9C0I1 CHOYP_LOC100161181.1.1 m.5983 sp MTMRC_HUMAN 33.036 112 68 1 15 126 14 118 4.16E-13 67.8 MTMRC_HUMAN reviewed Myotubularin-related protein 12 (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) MTMR12 KIAA1682 PIP3AP Homo sapiens (Human) 747 toxin transport [GO:1901998] GO:0005737; GO:0019208; GO:1901998 0 0 0 PF12578;PF06602; Q9ESN6 CHOYP_BRAFLDRAFT_110072.3.8 m.3992 sp TRIM2_MOUSE 30 220 134 10 179 389 536 744 4.16E-13 74.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9FE17 CHOYP_LOC100632618.3.3 m.35313 sp SIR1_ARATH 30.029 343 160 6 95 426 21 294 4.16E-38 147 SIR1_ARATH reviewed NAD-dependent protein deacetylase SRT1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) SRT1 At5g55760 MDF20.20 Arabidopsis thaliana (Mouse-ear cress) 473 0 GO:0005634; GO:0016787; GO:0046872; GO:0070403 0 0 0 PF02146; Q9UPT6 CHOYP_LOC100374908.1.1 m.51418 sp JIP3_HUMAN 56.596 235 83 4 20 245 408 632 4.16E-71 241 JIP3_HUMAN reviewed C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) MAPK8IP3 JIP3 KIAA1066 Homo sapiens (Human) 1336 activation of JUN kinase activity [GO:0007257]; axon guidance [GO:0007411]; forebrain development [GO:0030900]; in utero embryonic development [GO:0001701]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; post-embryonic development [GO:0009791]; protein localization [GO:0008104]; regulation of gene expression [GO:0010468]; regulation of JNK cascade [GO:0046328]; respiratory gaseous exchange [GO:0007585]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0001701; GO:0005078; GO:0005737; GO:0005790; GO:0007257; GO:0007411; GO:0007585; GO:0008104; GO:0008432; GO:0009791; GO:0010468; GO:0016192; GO:0019894; GO:0030159; GO:0030425; GO:0030673; GO:0030900; GO:0046328; GO:0048286; GO:0060425 0 0 0 PF16471;PF09744; Q9VCA9 CHOYP_FASN.3.4 m.60280 sp SPCS3_DROME 63.429 175 64 0 1 175 1 175 4.16E-81 241 SPCS3_DROME reviewed Signal peptidase complex subunit 3 (EC 3.4.-.-) (Microsomal signal peptidase 22 kDa subunit) (SPC22) (SPase 22 kDa subunit) Spase22-23 CG5677 Drosophila melanogaster (Fruit fly) 179 signal peptide processing [GO:0006465] GO:0005787; GO:0006465; GO:0008233; GO:0016021; GO:0031090 0 0 0 PF04573; Q9VCA9 CHOYP_LOC100373371.1.1 m.63195 sp SPCS3_DROME 63.429 175 64 0 1 175 1 175 4.16E-81 241 SPCS3_DROME reviewed Signal peptidase complex subunit 3 (EC 3.4.-.-) (Microsomal signal peptidase 22 kDa subunit) (SPC22) (SPase 22 kDa subunit) Spase22-23 CG5677 Drosophila melanogaster (Fruit fly) 179 signal peptide processing [GO:0006465] GO:0005787; GO:0006465; GO:0008233; GO:0016021; GO:0031090 0 0 0 PF04573; A3RLT6 CHOYP_LOC100543980.2.2 m.34220 sp RSSA_PINFU 72.5 120 28 5 1 118 174 290 4.17E-45 151 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; A4IF63 CHOYP_TRIM3.20.58 m.32447 sp TRIM2_BOVIN 27.068 266 169 9 290 543 491 743 4.17E-16 85.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5D989 CHOYP_LOC100373956.1.1 m.10987 sp EF1D_BOVIN 47.782 293 119 5 8 281 3 280 4.17E-77 238 EF1D_BOVIN reviewed Elongation factor 1-delta (EF-1-delta) EEF1D Bos taurus (Bovine) 280 cellular response to ionizing radiation [GO:0071479]; mRNA transcription [GO:0009299]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of cell death [GO:0010941] GO:0003677; GO:0003746; GO:0004871; GO:0005730; GO:0005783; GO:0005853; GO:0009299; GO:0010941; GO:0043123; GO:0071479 0 0 cd00292; PF10587;PF00736; O00214 CHOYP_LOC576472.1.1 m.2418 sp LEG8_HUMAN 39.416 137 77 2 78 214 185 315 4.17E-28 110 LEG8_HUMAN reviewed Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) LGALS8 Homo sapiens (Human) 317 xenophagy [GO:0098792] GO:0005615; GO:0005829; GO:0016020; GO:0030246; GO:0070062; GO:0098792 0 0 0 PF00337; O75382 CHOYP_contig_028971 m.32905 sp TRIM3_HUMAN 26.582 237 150 11 150 373 482 707 4.17E-11 68.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O95714 CHOYP_LOC100370069.9.14 m.55892 sp HERC2_HUMAN 46.479 71 32 2 141 209 1866 1932 4.17E-09 62 HERC2_HUMAN reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; intracellular protein transport [GO:0006886]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005743; GO:0005814; GO:0006303; GO:0006886; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016925; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; Q00610 CHOYP_CLTC.1.1 m.40277 sp CLH1_HUMAN 35.345 348 219 5 17 363 9 351 4.17E-72 247 CLH1_HUMAN reviewed Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) CLTC CLH17 CLTCL2 KIAA0034 Homo sapiens (Human) 1675 "antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular protein transport [GO:0006886]; mitotic nuclear division [GO:0007067]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; retrograde transport, endosome to Golgi [GO:0042147]; transferrin transport [GO:0033572]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0001649; GO:0003725; GO:0005198; GO:0005819; GO:0005829; GO:0005886; GO:0005925; GO:0006886; GO:0006898; GO:0007067; GO:0016020; GO:0019886; GO:0019901; GO:0030118; GO:0030130; GO:0030132; GO:0030136; GO:0030669; GO:0031012; GO:0031623; GO:0032051; GO:0032588; GO:0033572; GO:0036020; GO:0042147; GO:0042470; GO:0043231; GO:0043234; GO:0044822; GO:0060071; GO:0070062; GO:0071439; GO:1900126; GO:1903077; GO:1903561 0 0 0 PF00637;PF09268;PF01394; Q13310 CHOYP_LOC100370010.5.5 m.40353 sp PABP4_HUMAN 53.004 283 110 6 29 300 362 632 4.17E-71 234 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q4ZJM9 CHOYP_LOC100492438.1.1 m.4599 sp C1QL4_MOUSE 33.058 121 71 3 189 307 110 222 4.17E-09 59.3 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q502M6 CHOYP_TVAG_168010.43.45 m.61148 sp ANR29_DANRE 40.719 167 99 0 1 167 49 215 4.17E-33 124 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5U206 CHOYP_LOC100552424.1.1 m.36439 sp CALL3_RAT 35.211 142 88 1 77 218 12 149 4.17E-22 91.3 CALL3_RAT reviewed Calmodulin-like protein 3 Calml3 Rattus norvegicus (Rat) 149 0 GO:0005509; GO:0070062 0 0 0 PF13499; Q5ZL21 CHOYP_MMAC.1.1 m.8063 sp MMAC_CHICK 52.321 237 111 2 9 245 3 237 4.17E-86 259 MMAC_CHICK reviewed Methylmalonic aciduria and homocystinuria type C protein homolog (EC 1.16.1.-) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) MMACHC RCJMB04_8d5 Gallus gallus (Chicken) 238 0 GO:0005737 PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis. {ECO:0000250|UniProtKB:Q9Y4U1}. 0 cd12959; PF16690; Q62559 CHOYP_BRAFLDRAFT_281480.1.1 m.22698 sp IFT52_MOUSE 60.335 179 67 1 18 192 2 180 4.17E-74 233 IFT52_MOUSE reviewed Intraflagellar transport protein 52 homolog (Protein NGD5) Ift52 Ngd5 Mus musculus (Mouse) 426 cilium morphogenesis [GO:0060271]; determination of left/right symmetry [GO:0007368]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; intraciliary transport [GO:0042073]; negative regulation of epithelial cell proliferation [GO:0050680]; neural tube formation [GO:0001841]; regulation of protein processing [GO:0070613]; smoothened signaling pathway [GO:0007224] GO:0001841; GO:0001947; GO:0005813; GO:0005814; GO:0005929; GO:0007224; GO:0007368; GO:0009953; GO:0030992; GO:0032391; GO:0036064; GO:0042073; GO:0042733; GO:0044292; GO:0050680; GO:0060271; GO:0070613; GO:0072372; GO:0097542; GO:0097546 0 0 0 PF09822; Q641G4 CHOYP_LOC584403.1.1 m.18376 sp CNDH2_XENLA 36.364 660 343 18 8 627 2 624 4.17E-110 347 CNDH2_XENLA reviewed Condensin-2 complex subunit H2 (Non-SMC condensin II complex subunit H2) ncaph2 Xenopus laevis (African clawed frog) 624 chromosome condensation [GO:0030261] GO:0005634; GO:0030261 0 0 0 PF16858;PF06278; Q6B860 CHOYP_LOC100485757.1.1 m.48795 sp RT14_BOVIN 53.333 105 49 0 37 141 24 128 4.17E-37 126 RT14_BOVIN reviewed "28S ribosomal protein S14, mitochondrial (MRP-S14) (S14mt)" MRPS14 Bos taurus (Bovine) 128 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005763; GO:0032543; GO:0070124; GO:0070125 0 0 0 PF00253; Q6PFY8 CHOYP_LOC100368020.6.29 m.17074 sp TRI45_MOUSE 28.846 208 131 6 8 209 129 325 4.17E-14 75.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6XK22 CHOYP_LOC100558698.1.1 m.49027 sp R9BP_CHICK 32.78 241 144 6 38 269 2 233 4.17E-28 110 R9BP_CHICK reviewed Regulator of G-protein signaling 9-binding protein (RGS9-anchor protein) RGS9BP R9AP Gallus gallus (Chicken) 237 detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of signal transduction [GO:0009968] GO:0001750; GO:0009968; GO:0016021; GO:0050908 0 0 0 0 Q8QGW7 CHOYP_GLRA3.1.2 m.53462 sp LITAF_CHICK 46.667 105 53 2 16 119 46 148 4.17E-23 90.5 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8QGW7 CHOYP_LOC100369143.2.2 m.65132 sp LITAF_CHICK 46.667 105 53 2 16 119 46 148 4.17E-23 90.5 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q8QGW7 CHOYP_LOC100560334.3.3 m.50401 sp LITAF_CHICK 46.667 105 53 2 16 119 46 148 4.17E-23 90.5 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q92113 CHOYP_LOC100371830.3.6 m.21890 sp CP17A_SQUAC 33.557 447 282 6 31 468 31 471 4.17E-87 284 CP17A_SQUAC reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) 509 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q96KG7 CHOYP_MEG10.76.91 m.58143 sp MEG10_HUMAN 42.105 95 47 6 11 104 572 659 4.17E-09 55.5 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q9BUK0 CHOYP_LOC100695438.1.1 m.8596 sp CHCH7_HUMAN 33.333 72 48 0 44 115 12 83 4.17E-13 63.2 CHCH7_HUMAN reviewed Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 CHCHD7 Homo sapiens (Human) 85 0 GO:0005758 0 0 0 0 Q9NUS5 CHOYP_LOC100367116.1.1 m.28435 sp AP5S1_HUMAN 37.629 194 110 4 20 203 1 193 4.17E-26 102 AP5S1_HUMAN reviewed AP-5 complex subunit sigma-1 (Adaptor-related protein complex 5 sigma subunit) (Sigma5) AP5S1 C20orf29 Homo sapiens (Human) 200 double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031] GO:0000724; GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0005770; GO:0005829; GO:0015031; GO:0016197; GO:0030119; GO:0031902 0 0 0 PF15001; A8E5W8 CHOYP_BRAFLDRAFT_118265.1.1 m.46745 sp F166B_XENTR 43.103 290 157 6 8 294 13 297 4.18E-69 219 F166B_XENTR reviewed Protein FAM166B fam166b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 306 0 0 0 0 0 PF10629; B0V207 CHOYP_F16A2.2.3 m.49840 sp F16A2_DANRE 44.646 607 284 13 1 583 1 579 4.18E-149 477 F16A2_DANRE reviewed FTS and Hook-interacting protein homolog (FHIP) (Protein FAM160A2) fam160a2 si:ch211-39h10.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1124 early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein transport [GO:0015031] GO:0005829; GO:0007032; GO:0007040; GO:0008333; GO:0015031; GO:0045022; GO:0070695 0 0 0 PF10257; D8VNS7 CHOYP_LOC100632478.1.2 m.54199 sp FCNV1_CERRY 49.735 189 85 4 336 523 128 307 4.18E-51 181 FCNV1_CERRY reviewed Ryncolin-1 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; O75382 CHOYP_BRAFLDRAFT_109857.13.15 m.53841 sp TRIM3_HUMAN 22.422 223 144 9 123 332 536 742 4.18E-06 52 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_87312.1.4 m.2297 sp TRIM3_HUMAN 24.719 267 171 12 338 588 492 744 4.18E-07 57 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0C6B8 CHOYP_SVEP1.2.8 m.26503 sp SVEP1_RAT 27.628 333 181 15 8 302 528 838 4.18E-14 78.2 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P30151 CHOYP_EEF1B2.1.1 m.5875 sp EF1B_XENLA 60.993 141 48 2 8 141 73 213 4.18E-49 161 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P78417 CHOYP_GSTO2.1.1 m.36486 sp GSTO1_HUMAN 50 120 57 3 2 119 5 123 4.18E-36 127 GSTO1_HUMAN reviewed Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) GSTO1 GSTTLP28 Homo sapiens (Human) 241 cellular response to arsenic-containing substance [GO:0071243]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; L-ascorbic acid biosynthetic process [GO:0019853]; L-ascorbic acid metabolic process [GO:0019852]; methylation [GO:0032259]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [GO:0014810]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; xenobiotic catabolic process [GO:0042178] GO:0004364; GO:0005604; GO:0005737; GO:0005829; GO:0006749; GO:0010880; GO:0010881; GO:0014810; GO:0016491; GO:0019852; GO:0019853; GO:0030424; GO:0031965; GO:0032259; GO:0042178; GO:0043209; GO:0044297; GO:0045174; GO:0050610; GO:0060315; GO:0060316; GO:0070062; GO:0071243; GO:1901687 0 0 0 PF14497;PF13417; P82147 CHOYP_LOC100644627.1.1 m.63495 sp L2EFL_DROME 33.333 78 51 1 261 337 76 153 4.18E-09 58.9 L2EFL_DROME reviewed Protein lethal(2)essential for life (Protein Efl21) l(2)efl CG4533 Drosophila melanogaster (Fruit fly) 187 multicellular organism development [GO:0007275]; protein refolding [GO:0042026]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to heat [GO:0009408]; sarcomere organization [GO:0045214] GO:0007275; GO:0009408; GO:0010998; GO:0030018; GO:0042026; GO:0045214; GO:0048471 0 0 0 PF00011; P97347 CHOYP_UAFA.7.8 m.45137 sp RPTN_MOUSE 23.288 146 112 0 689 834 338 483 4.18E-09 64.3 RPTN_MOUSE reviewed Repetin Rptn Mus musculus (Mouse) 1118 0 GO:0001533; GO:0005509; GO:0005578 0 0 0 PF01023; Q1EG27 CHOYP_LOC373229.2.3 m.43412 sp MYO3B_MOUSE 36.286 824 475 16 6 808 334 1128 4.18E-142 483 MYO3B_MOUSE reviewed Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) 1305 peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0000146; GO:0001750; GO:0001917; GO:0004674; GO:0005524; GO:0005737; GO:0007601; GO:0016459; GO:0018105; GO:0018107; GO:0032426; GO:0032433; GO:0046777; GO:0050896; GO:0051491 0 0 0 PF00612;PF00063;PF00069; Q502M6 CHOYP_LOC578974.7.11 m.39666 sp ANR29_DANRE 41.085 129 76 0 27 155 59 187 4.18E-25 100 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5RC32 CHOYP_MDM1.1.2 m.7535 sp MDM1_PONAB 26.677 656 358 26 236 863 162 722 4.18E-28 124 MDM1_PONAB reviewed Nuclear protein MDM1 MDM1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 724 negative regulation of centriole replication [GO:0046600] GO:0005634; GO:0005813; GO:0005814; GO:0005874; GO:0008017; GO:0046600 0 0 0 PF15501; Q61361 CHOYP_PGCB.2.2 m.43444 sp PGCB_MOUSE 44.444 45 25 0 27 71 617 661 4.18E-07 52.8 PGCB_MOUSE reviewed Brevican core protein Bcan Mus musculus (Mouse) 883 cell adhesion [GO:0007155]; hippocampus development [GO:0021766]; regulation of neuronal synaptic plasticity [GO:0048168]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005578; GO:0005615; GO:0007155; GO:0021766; GO:0030246; GO:0030425; GO:0031225; GO:0045202; GO:0048168 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; Q6AYG7 CHOYP_LOC100565002.1.1 m.14843 sp NF2IP_RAT 25 212 138 6 154 356 213 412 4.18E-10 64.3 NF2IP_RAT reviewed "NFATC2-interacting protein (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)" Nfatc2ip Rattus norvegicus (Rat) 414 cytokine production [GO:0001816]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein sumoylation [GO:0016925] GO:0001816; GO:0005634; GO:0005737; GO:0016925; GO:0031386; GO:0045944 0 0 0 PF11976; Q6GPV5 CHOYP_RN181.1.1 m.44241 sp RN181_XENLA 36.207 116 68 2 79 189 9 123 4.18E-18 80.1 RN181_XENLA reviewed E3 ubiquitin-protein ligase RNF181 (EC 6.3.2.-) (RING finger protein 181) rnf181 Xenopus laevis (African clawed frog) 156 protein ubiquitination [GO:0016567] GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q6INU7 CHOYP_DYAK_GE11746.1.1 m.8207 sp FRRS1_XENLA 26.46 548 325 21 47 571 50 542 4.18E-46 175 FRRS1_XENLA reviewed Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) 590 0 GO:0016021; GO:0016491 0 0 cd08544; PF03188;PF03351;PF02014; Q7T2V2 CHOYP_ST1S3.1.1 m.54159 sp ST1S3_DANRE 30.945 307 181 9 1 290 3 295 4.18E-39 142 ST1S3_DANRE reviewed Cytosolic sulfotransferase 3 (EC 2.8.2.-) (SULT1 ST3) sult1st3 Danio rerio (Zebrafish) (Brachydanio rerio) 301 catecholamine metabolic process [GO:0006584]; steroid metabolic process [GO:0008202]; xenobiotic metabolic process [GO:0006805] GO:0005737; GO:0006584; GO:0006805; GO:0008146; GO:0008202 0 0 0 PF00685; Q80XI3 CHOYP_BRAFLDRAFT_165799.1.1 m.33332 sp IF4G3_MOUSE 41.935 186 104 3 1 182 1332 1517 4.18E-39 144 IF4G3_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Eif4g3 Mus musculus (Mouse) 1579 positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283] GO:0001934; GO:0003743; GO:0007283; GO:0044822; GO:0045727; GO:0060903 0 0 0 PF02847;PF02854;PF02020; Q80YX1 CHOYP_ANGP4.6.7 m.52534 sp TENA_MOUSE 46.429 196 99 5 130 322 1905 2097 4.18E-50 182 TENA_MOUSE reviewed Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) 2110 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] GO:0001649; GO:0001968; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; Q8C6L5 CHOYP_NEMVEDRAFT_V1G218264.13.14 m.58510 sp CGAS_MOUSE 25 240 153 8 41 256 265 501 4.18E-09 62.8 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q99996 CHOYP_LOC100368547.30.40 m.45293 sp AKAP9_HUMAN 48.98 49 25 0 73 121 3584 3632 4.18E-06 47.8 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9CZX2 CHOYP_CEP89.1.2 m.14339 sp CEP89_MOUSE 35.436 539 312 6 165 683 220 742 4.18E-89 299 CEP89_MOUSE reviewed Centrosomal protein of 89 kDa (Cep89) (Coiled-coil domain-containing protein 123) Cep89 Ccdc123 Mus musculus (Mouse) 791 chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0042384]; mitochondrion organization [GO:0007005]; nonmotile primary cilium assembly [GO:0035058] GO:0000922; GO:0005737; GO:0005758; GO:0005813; GO:0005814; GO:0005829; GO:0005886; GO:0007005; GO:0007268; GO:0031513; GO:0031514; GO:0035058; GO:0042384; GO:0097539 0 0 0 0 Q9H3U5 CHOYP_BRAFLDRAFT_128311.2.2 m.60848 sp MFSD1_HUMAN 32.265 468 268 7 8 464 35 464 4.18E-65 220 MFSD1_HUMAN reviewed Major facilitator superfamily domain-containing protein 1 (Smooth muscle cell-associated protein 4) (SMAP-4) MFSD1 SMAP4 UG0581B09 Homo sapiens (Human) 465 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q9HAS0 CHOYP_LOC592013.1.1 m.20072 sp NJMU_HUMAN 29.262 393 233 9 2 369 19 391 4.18E-46 165 NJMU_HUMAN reviewed Protein Njmu-R1 C17orf75 Homo sapiens (Human) 396 0 0 0 0 0 PF15053; Q9V439 CHOYP_LOC659964.1.1 m.25995 sp MED22_DROME 66.176 136 46 0 2 137 5 140 4.18E-58 179 MED22_DROME reviewed Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (dMED24) MED22 Med24 CG3034 Drosophila melanogaster (Fruit fly) 143 "mitotic nuclear division [GO:0007067]; negative regulation of neuroblast proliferation [GO:0007406]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0005634; GO:0006351; GO:0006357; GO:0007067; GO:0007406; GO:0016592 0 0 0 PF06179; A4IF63 CHOYP_BRAFLDRAFT_92727.15.17 m.53639 sp TRIM2_BOVIN 25 148 96 4 46 190 609 744 4.19E-06 50.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6BM72 CHOYP_MEG10.33.91 m.37559 sp MEG11_HUMAN 34.755 469 266 23 196 656 352 788 4.19E-50 193 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; B3EWY9 CHOYP_LOC575161.2.5 m.4638 sp MLP_ACRMI 27.615 1061 629 35 844 1849 389 1365 4.19E-101 365 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; E1BD59 CHOYP_LOC100567036.1.2 m.19167 sp TRI56_BOVIN 31.737 334 214 5 58 383 9 336 4.19E-48 184 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O18783 CHOYP_PLMN.11.11 m.51036 sp PLMN_MACEU 39.118 340 144 13 293 606 108 410 4.19E-55 203 PLMN_MACEU reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macropus eugenii (Tammar wallaby) 806 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; O75808 CHOYP_SOLH.2.2 m.52301 sp CAN15_HUMAN 28.691 718 406 26 93 751 416 1086 4.19E-80 281 CAN15_HUMAN reviewed Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) CAPN15 SOLH Homo sapiens (Human) 1086 0 GO:0003700; GO:0004198; GO:0005737; GO:0008233; GO:0008234; GO:0008270 0 0 0 PF00648;PF00641; P10155 CHOYP_LOC100377747.3.3 m.57893 sp RO60_HUMAN 41.336 554 293 11 33 583 9 533 4.19E-135 407 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P14318 CHOYP_LOC732906.1.1 m.25076 sp MP20_DROME 53.125 96 37 2 11 98 86 181 4.19E-25 95.5 MP20_DROME reviewed Muscle-specific protein 20 Mp20 Tpn CG4696 Drosophila melanogaster (Fruit fly) 184 cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739] GO:0003779; GO:0007155; GO:0007520; GO:0008360; GO:1901739 0 0 0 PF00402;PF00307; P24392 CHOYP_PEX2.2.2 m.26980 sp PEX2_RAT 41.281 281 158 3 10 284 15 294 4.19E-72 227 PEX2_RAT reviewed Peroxisome biogenesis factor 2 (Peroxin-2) (Peroxisomal membrane protein 3) (Peroxisome assembly factor 1) (PAF-1) Pex2 Paf1 Pmp35 Pxmp3 Rattus norvegicus (Rat) 305 fatty acid beta-oxidation [GO:0006635]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein destabilization [GO:0031648]; protein import into peroxisome matrix [GO:0016558]; very long-chain fatty acid metabolic process [GO:0000038] GO:0000038; GO:0000122; GO:0005777; GO:0005778; GO:0005779; GO:0006635; GO:0008270; GO:0016020; GO:0016558; GO:0016593; GO:0031648; GO:0048147; GO:0050680 0 0 0 PF04757;PF00097; P28799 CHOYP_BRAFLDRAFT_102424.4.6 m.51652 sp GRN_HUMAN 39.292 565 288 14 58 607 67 591 4.19E-114 358 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P78312 CHOYP_FAM193A.1.1 m.66343 sp F193A_HUMAN 44.351 239 112 6 266 493 1 229 4.19E-56 218 F193A_HUMAN reviewed Protein FAM193A (Protein IT14) FAM193A C4orf8 RES4-22 Homo sapiens (Human) 1265 0 0 0 0 0 PF15914; P92204 CHOYP_PHUM_PHUM616130.1.1 m.47653 sp NELFE_DROME 46.918 292 133 9 1 283 1 279 4.19E-58 190 NELFE_DROME reviewed Negative elongation factor E Nelf-E anon-66Da CG5994 Drosophila melanogaster (Fruit fly) 280 "negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter during mitosis [GO:0007070]; neurogenesis [GO:0022008]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription elongation from RNA polymerase II promoter [GO:0006368]" GO:0000122; GO:0000166; GO:0003723; GO:0003729; GO:0005634; GO:0005694; GO:0006368; GO:0007070; GO:0008023; GO:0017053; GO:0022008; GO:0032021; GO:0032785; GO:0034244; GO:0045944 0 0 0 PF00076; Q14162 CHOYP_MEGF11.2.11 m.23325 sp SREC_HUMAN 32.093 215 91 10 183 384 213 385 4.19E-15 80.5 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q49LS8 CHOYP_SPTC2.3.4 m.22360 sp XKR6_TETNG 26.136 264 151 5 167 404 83 328 4.19E-17 87 XKR6_TETNG reviewed XK-related protein 6 xkr6 xrg6 GSTENG00030285001 GSTENG00030286001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 578 0 GO:0016021 0 0 0 PF09815; Q57951 CHOYP_LOC100185549.5.6 m.62694 sp Y531_METJA 36.054 147 80 4 6 145 27 166 4.19E-12 63.5 Y531_METJA reviewed Universal stress protein MJ0531 (USP MJ0531) MJ0531 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 170 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q58EG3 CHOYP_PVRL1.3.3 m.65863 sp NECT3_DANRE 24.566 346 206 21 2 332 21 326 4.19E-09 62.8 NECT3_DANRE reviewed Nectin-3-like protein (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3-like) nectin3 pvrl3l si:dkey-62a13.5 zgc:113035 Danio rerio (Zebrafish) (Brachydanio rerio) 574 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0042803; GO:0050839 0 0 0 PF08205;PF07686; Q641W2 CHOYP_LOC100698240.4.4 m.18891 sp MYG1_RAT 59.868 152 61 0 2 153 215 366 4.19E-63 201 MYG1_RAT reviewed "UPF0160 protein MYG1, mitochondrial" Myg1 C12orf10 Rattus norvegicus (Rat) 381 locomotory exploration behavior [GO:0035641] GO:0005654; GO:0005739; GO:0035641; GO:0070062 0 0 0 PF03690; Q6NVF4 CHOYP_HELB.1.2 m.22389 sp HELB_MOUSE 40 50 30 0 1 50 723 772 4.19E-06 47 HELB_MOUSE reviewed DNA helicase B (EC 3.6.4.12) Helb Mus musculus (Mouse) 1074 "cellular response to DNA damage stimulus [GO:0006974]; DNA-dependent DNA replication [GO:0006261]; DNA replication [GO:0006260]; DNA replication, synthesis of RNA primer [GO:0006269]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of DNA double-strand break processing [GO:1903775]" GO:0000398; GO:0004003; GO:0004004; GO:0005524; GO:0005634; GO:0005658; GO:0005681; GO:0005737; GO:0006260; GO:0006261; GO:0006269; GO:0006974; GO:0017116; GO:0035861; GO:0043141; GO:0044822; GO:1903775; GO:2000042 0 0 0 PF13538; Q6P2X9 CHOYP_MOT8.2.2 m.19645 sp MOT12_XENTR 23.982 442 299 6 102 510 14 451 4.19E-30 126 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q7ZTZ2 CHOYP_RLP24.1.2 m.25973 sp RLP24_DANRE 63.043 92 31 2 12 102 72 161 4.19E-31 110 RLP24_DANRE reviewed Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) rsl24d1 zgc:56202 Danio rerio (Zebrafish) (Brachydanio rerio) 161 assembly of large subunit precursor of preribosome [GO:1902626]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625; GO:1902626 0 0 cd00472; PF01246; Q7ZWN9 CHOYP_TTYH2.1.1 m.61112 sp TTYH2_XENLA 27.132 516 329 13 8 492 12 511 4.19E-52 188 TTYH2_XENLA reviewed Protein tweety homolog 2 ttyh2 Xenopus laevis (African clawed frog) 534 0 GO:0005254; GO:0005886; GO:0034707 0 0 cd07912; PF04906; Q86VZ4 CHOYP_LOC100891701.1.1 m.28457 sp LRP11_HUMAN 27.294 436 216 14 108 481 104 500 4.19E-26 114 LRP11_HUMAN reviewed Low-density lipoprotein receptor-related protein 11 (LRP-11) LRP11 Homo sapiens (Human) 500 multicellular organismal response to stress [GO:0033555]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to immobilization stress [GO:0035902]; response to mechanical stimulus [GO:0009612]; response to starvation [GO:0042594]; response to water deprivation [GO:0009414] GO:0005886; GO:0009408; GO:0009409; GO:0009414; GO:0009612; GO:0016021; GO:0033555; GO:0035902; GO:0042594; GO:0051219 0 0 0 PF00057;PF07502; Q8BX13 CHOYP_UBE3D.1.1 m.12962 sp UBE3D_MOUSE 27.762 353 187 14 70 403 65 368 4.19E-28 117 UBE3D_MOUSE reviewed E3 ubiquitin-protein ligase E3D (EC 6.3.2.-) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein) Ube3d H10bh Ube2cbp Mus musculus (Mouse) 368 protein ubiquitination [GO:0016567] GO:0005737; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF09814; Q96RK0 CHOYP_CIC.1.2 m.57436 sp CIC_HUMAN 36.417 508 195 20 840 1259 30 497 4.19E-60 233 CIC_HUMAN reviewed Protein capicua homolog CIC KIAA0306 Homo sapiens (Human) 1608 "lung alveolus development [GO:0048286]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0048286 0 0 0 PF00505; Q99502 CHOYP_BRAFLDRAFT_83679.2.2 m.56210 sp EYA1_HUMAN 55.603 464 165 6 199 648 156 592 4.19E-171 503 EYA1_HUMAN reviewed Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) EYA1 Homo sapiens (Human) 592 "anatomical structure morphogenesis [GO:0009653]; aorta morphogenesis [GO:0035909]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular protein localization [GO:0034613]; cochlea morphogenesis [GO:0090103]; double-strand break repair [GO:0006302]; embryonic skeletal system morphogenesis [GO:0048704]; establishment of mitotic spindle orientation [GO:0000132]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; histone dephosphorylation [GO:0016576]; lung epithelial cell differentiation [GO:0060487]; mesodermal cell fate specification [GO:0007501]; metanephros development [GO:0001656]; middle ear morphogenesis [GO:0042474]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neuron fate specification [GO:0048665]; otic vesicle morphogenesis [GO:0071600]; outer ear morphogenesis [GO:0042473]; outflow tract morphogenesis [GO:0003151]; pattern specification process [GO:0007389]; pharyngeal system development [GO:0060037]; positive regulation of DNA repair [GO:0045739]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein sumoylation [GO:0016925]; regulation of neuron differentiation [GO:0045664]; response to ionizing radiation [GO:0010212]; semicircular canal morphogenesis [GO:0048752]; sensory perception of sound [GO:0007605]; striated muscle tissue development [GO:0014706]; transcription, DNA-templated [GO:0006351]" GO:0000132; GO:0001656; GO:0001658; GO:0003151; GO:0003723; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006351; GO:0007389; GO:0007501; GO:0007605; GO:0009653; GO:0010212; GO:0014706; GO:0016576; GO:0016925; GO:0032993; GO:0034613; GO:0035088; GO:0035909; GO:0042473; GO:0042474; GO:0043234; GO:0045664; GO:0045739; GO:0045747; GO:0045944; GO:0046872; GO:0048665; GO:0048704; GO:0048752; GO:0050679; GO:0060037; GO:0060487; GO:0071600; GO:0072513; GO:0090103; GO:2001240 0 0 0 0 Q9BXT6 CHOYP_MOV10L1.1.1 m.15983 sp M10L1_HUMAN 32.45 943 487 22 1 822 1 914 4.19E-129 418 M10L1_HUMAN reviewed RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) MOV10L1 Homo sapiens (Human) 1211 DNA methylation involved in gamete generation [GO:0043046]; germ cell development [GO:0007281]; male meiosis I [GO:0007141]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0000287; GO:0003723; GO:0004004; GO:0005524; GO:0005622; GO:0007141; GO:0007275; GO:0007281; GO:0007283; GO:0034587; GO:0043046; GO:0043186; GO:0071546 0 0 0 0 Q9FKR0 CHOYP_contig_014877 m.17157 sp MT878_ARATH 26.906 223 131 9 47 242 59 276 4.19E-10 63.2 MT878_ARATH reviewed Probable S-adenosylmethionine-dependent methyltransferase At5g38780 (EC 2.1.1.-) At5g38780 MKD10.80 Arabidopsis thaliana (Mouse-ear cress) 361 0 GO:0008168 0 0 0 PF03492; Q9NVX0 CHOYP_LOC582814.1.1 m.40745 sp HAUS2_HUMAN 28.07 171 122 1 28 198 5 174 4.19E-16 77.8 HAUS2_HUMAN reviewed HAUS augmin-like complex subunit 2 (Centrosomal protein of 27 kDa) (Cep27) HAUS2 C15orf25 CEP27 Homo sapiens (Human) 235 cell division [GO:0051301]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0000086; GO:0005654; GO:0005737; GO:0005794; GO:0005813; GO:0005829; GO:0005876; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 PF15003; Q9Y4R7 CHOYP_LOC578867.1.5 m.11620 sp TTLL3_HUMAN 47.126 435 218 6 609 1033 179 611 4.19E-128 416 TTLL3_HUMAN reviewed Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3) TTLL3 PRO0207 Homo sapiens (Human) 772 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; protein polyglycylation [GO:0018094] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0035082; GO:0042384; GO:0070735; GO:0070736 0 0 0 PF03133; O75095 CHOYP_LOC100184792.2.3 m.55487 sp MEGF6_HUMAN 35.714 322 184 10 174 494 719 1018 4.20E-42 167 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P08686 CHOYP_LOC100371830.1.6 m.12496 sp CP21A_HUMAN 36.923 130 81 1 5 134 27 155 4.20E-19 85.1 CP21A_HUMAN reviewed Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B) CYP21A2 CYP21 CYP21B Homo sapiens (Human) 494 glucocorticoid biosynthetic process [GO:0006704]; mineralocorticoid biosynthetic process [GO:0006705]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202]; sterol metabolic process [GO:0016125] GO:0004509; GO:0005496; GO:0005506; GO:0005789; GO:0006694; GO:0006704; GO:0006705; GO:0008202; GO:0008395; GO:0016125; GO:0020037; GO:0031090 0 0 0 PF00067; P48166 CHOYP_LOC100180220.3.3 m.66851 sp RL36A_CAEEL 79.31 87 18 0 13 99 16 102 4.20E-44 141 RL36A_CAEEL reviewed Ribosomal protein L36.A (60S ribosomal protein L44) (L41) rpl-36.A rpl-41 C09H10.2 Caenorhabditis elegans 105 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00935; P57103 CHOYP_LOC100371845.3.3 m.62472 sp NAC3_HUMAN 35.754 895 472 18 25 844 54 920 4.20E-161 496 NAC3_HUMAN reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) SLC8A3 NCX3 Homo sapiens (Human) 927 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; ion transport [GO:0006811]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005886; GO:0005887; GO:0006811; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0016528; GO:0021537; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1903779; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; P70665 CHOYP_BRAFLDRAFT_217332.2.2 m.51240 sp SIAE_MOUSE 39.306 519 264 10 31 510 28 534 4.20E-123 374 SIAE_MOUSE reviewed Sialate O-acetylesterase (EC 3.1.1.53) (Sialic acid-specific 9-O-acetylesterase) (Yolk sac protein 2) [Cleaved into: Sialate O-acetylesterase small subunit; Sialate O-acetylesterase large subunit] Siae Ysg2 Mus musculus (Mouse) 541 carbohydrate metabolic process [GO:0005975]; regulation of immune system process [GO:0002682] GO:0001681; GO:0002682; GO:0005615; GO:0005764; GO:0005975; GO:0070062 0 0 0 PF03629; P70684 CHOYP_HPGD.2.3 m.50419 sp PGDH_CAVPO 42.703 185 101 2 1 181 71 254 4.20E-45 152 PGDH_CAVPO reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) 265 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; P83425 CHOYP_contig_003145 m.3479 sp HIP_MYTED 30.189 106 74 0 147 252 83 188 4.20E-07 53.1 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P85834 CHOYP_LOC101070424.1.1 m.64148 sp EFTU_RAT 53.747 387 177 2 58 443 54 439 4.20E-152 443 EFTU_RAT reviewed "Elongation factor Tu, mitochondrial" Tufm Rattus norvegicus (Rat) 452 mitochondrial translational elongation [GO:0070125]; response to ethanol [GO:0045471] GO:0003746; GO:0003924; GO:0005525; GO:0005739; GO:0016020; GO:0042645; GO:0044822; GO:0045471; GO:0070062; GO:0070125 0 0 cd03697; PF03144;PF03143; Q09363 CHOYP_BRAFLDRAFT_92974.1.1 m.62414 sp SQV8_CAEEL 45.808 334 164 7 15 335 16 345 4.20E-91 279 SQV8_CAEEL reviewed Probable glucuronosyltransferase sqv-8 (EC 2.4.1.135) (Squashed vulva protein 8) (Vulval invagination protein sqv-8) sqv-8 ZK1307.5 Caenorhabditis elegans 356 carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; embryo development ending in birth or egg hatching [GO:0009792]; morphogenesis of an epithelium [GO:0002009]; oviposition [GO:0018991]; pharynx development [GO:0060465]; reproduction [GO:0000003]; spermatid development [GO:0007286]; vulval development [GO:0040025] GO:0000003; GO:0002009; GO:0005975; GO:0007286; GO:0009792; GO:0015018; GO:0015020; GO:0016020; GO:0016021; GO:0018991; GO:0030206; GO:0040025; GO:0046872; GO:0060465 0 0 0 PF03360; Q1NZ26 CHOYP_LOC100371723.1.1 m.18486 sp YSMU_CAEEL 50 196 91 1 236 431 84 272 4.20E-58 195 YSMU_CAEEL reviewed "Uncharacterized protein F13E9.13, mitochondrial" F13E9.13 Caenorhabditis elegans 277 metabolic process [GO:0008152] GO:0003824; GO:0005739; GO:0008152 0 0 0 PF03437; Q2VL62 CHOYP_PAX9.1.1 m.63730 sp PAX9_PANTR 63.296 267 66 12 5 268 4 241 4.20E-92 278 PAX9_PANTR reviewed Paired box protein Pax-9 PAX9 Pan troglodytes (Chimpanzee) 341 "organ morphogenesis [GO:0009887]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0009887 0 0 0 PF00292; Q32KR8 CHOYP_BRAFLDRAFT_212086.1.11 m.20083 sp ADPRH_BOVIN 57.993 269 109 2 1 268 87 352 4.20E-102 309 ADPRH_BOVIN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Bos taurus (Bovine) 353 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q3SZ90 CHOYP_RL13A.2.3 m.30851 sp RL13A_BOVIN 61.607 112 43 0 1 112 79 190 4.20E-45 147 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q4V348 CHOYP_LOC100918713.1.1 m.17833 sp Z658B_HUMAN 27.616 344 202 12 1 314 395 721 4.20E-19 93.2 Z658B_HUMAN reviewed Zinc finger protein 658B ZNF658B Homo sapiens (Human) 819 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q640R7 CHOYP_RAP1B.1.1 m.37174 sp RAP1B_XENTR 83.422 187 27 2 1 186 1 184 4.20E-110 315 RAP1B_XENTR reviewed Ras-related protein Rap-1b rap1b TTpA008e07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 184 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005829; GO:0005886; GO:0007264; GO:0030054 0 0 0 PF00071; Q6GYQ0 CHOYP_RALGAPA1.1.1 m.44741 sp RGPA1_HUMAN 57.895 76 28 1 1 72 1959 2034 4.20E-22 93.6 RGPA1_HUMAN reviewed Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) RALGAPA1 GARNL1 KIAA0884 TULIP1 Homo sapiens (Human) 2036 "activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005096; GO:0005634; GO:0005737; GO:0006355; GO:0046982; GO:0051056; GO:0090630 0 0 0 PF02145; Q7ZV00 CHOYP_DVIR_GJ11458.1.1 m.52434 sp OTU6B_DANRE 23.556 225 135 8 457 680 103 291 4.20E-08 59.3 OTU6B_DANRE reviewed OTU domain-containing protein 6B (EC 3.4.19.12) otud6b zgc:56305 Danio rerio (Zebrafish) (Brachydanio rerio) 293 0 GO:0036459 0 0 0 PF02338; Q86XX4 CHOYP_LOC763281.1.1 m.56355 sp FRAS1_HUMAN 37.356 696 419 6 2 687 1664 2352 4.20E-142 462 FRAS1_HUMAN reviewed Extracellular matrix protein FRAS1 FRAS1 KIAA1500 Homo sapiens (Human) 4008 cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; palate development [GO:0060021]; protein transport [GO:0015031]; skin development [GO:0043588] GO:0002009; GO:0003338; GO:0005886; GO:0007154; GO:0015031; GO:0016021; GO:0030326; GO:0043588; GO:0046872; GO:0060021; GO:0061618 0 0 0 PF03160;PF00093; Q8C6L5 CHOYP_LOC100377009.7.10 m.58512 sp CGAS_MOUSE 28.025 157 91 5 33 171 328 480 4.20E-08 59.3 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8ITC3 CHOYP_RS19.12.12 m.66567 sp RS19_ARGIR 70.922 141 40 1 19 159 1 140 4.20E-71 214 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q96DM1 CHOYP_LOC100661020.5.5 m.38728 sp PGBD4_HUMAN 28.535 396 252 12 1 376 192 576 4.20E-31 127 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9DBM0 CHOYP_ABCG8.1.1 m.3706 sp ABCG8_MOUSE 42.434 608 332 7 70 662 68 672 4.20E-164 489 ABCG8_MOUSE reviewed ATP-binding cassette sub-family G member 8 (Sterolin-2) Abcg8 Mus musculus (Mouse) 673 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; excretion [GO:0007588]; intestinal cholesterol absorption [GO:0030299]; negative regulation of intestinal cholesterol absorption [GO:0045796]; negative regulation of intestinal phytosterol absorption [GO:0010949]; phospholipid transport [GO:0015914]; response to drug [GO:0042493]; response to nutrient [GO:0007584]; sterol homeostasis [GO:0055092]; sterol transport [GO:0015918] GO:0005524; GO:0007584; GO:0007588; GO:0010949; GO:0015914; GO:0015918; GO:0016021; GO:0016324; GO:0017127; GO:0030299; GO:0033344; GO:0042493; GO:0042626; GO:0042632; GO:0043190; GO:0043235; GO:0045796; GO:0046982; GO:0055092 0 0 0 PF01061;PF00005; Q9ESN6 CHOYP_LOC100374342.4.19 m.24100 sp TRIM2_MOUSE 26.471 204 134 7 349 544 536 731 4.20E-09 63.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9IA76 CHOYP_TNPO1.1.1 m.8876 sp RL31_PAROL 72.131 122 34 0 1 122 1 122 4.20E-62 188 RL31_PAROL reviewed 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) 124 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00463; PF01198; A2RT67 CHOYP_LOC100083076.1.1 m.35327 sp DEND3_MOUSE 30.7 1228 707 35 155 1300 106 1271 4.21E-171 546 DEND3_MOUSE reviewed DENN domain-containing protein 3 Dennd3 Kiaa0870 Mus musculus (Mouse) 1274 cellular protein catabolic process [GO:0044257]; endosome to lysosome transport [GO:0008333] GO:0005622; GO:0008333; GO:0017112; GO:0044257 0 0 0 PF02141; B4E2M5 CHOYP_LOC100368623.1.1 m.5493 sp ANR66_HUMAN 38.926 149 88 1 1 146 61 209 4.21E-32 117 ANR66_HUMAN reviewed Ankyrin repeat domain-containing protein 66 ANKRD66 Homo sapiens (Human) 251 0 0 0 0 0 PF12796; O54891 CHOYP_LOC100535066.1.2 m.15640 sp LEG6_MOUSE 32.107 299 173 10 66 340 9 301 4.21E-37 141 LEG6_MOUSE reviewed Galectin-6 (Gal-6) Lgals6 Mus musculus (Mouse) 301 0 GO:0030246 0 0 0 PF00337; O70277 CHOYP_BRAFLDRAFT_205965.25.43 m.46273 sp TRIM3_RAT 22.695 141 105 2 64 200 593 733 4.21E-07 52.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P29121 CHOYP_PCSK4.2.2 m.64223 sp PCSK4_MOUSE 35.917 529 302 16 52 564 49 556 4.21E-95 310 PCSK4_MOUSE reviewed Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (KEX2-like endoprotease 3) (Neuroendocrine convertase 3) (NEC 3) (Prohormone convertase 3) Pcsk4 Nec-3 Nec3 Mus musculus (Mouse) 655 acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; nerve growth factor processing [GO:0032455]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240] GO:0001669; GO:0002080; GO:0004252; GO:0005615; GO:0005788; GO:0007339; GO:0007340; GO:0009566; GO:0016485; GO:0022414; GO:0032455; GO:0048240 0 0 0 PF01483;PF00082;PF16470; P50607 CHOYP_TULP1.1.1 m.4820 sp TUB_HUMAN 71.815 259 67 1 289 541 248 506 4.21E-143 425 TUB_HUMAN reviewed Tubby protein homolog TUB Homo sapiens (Human) 506 "phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to nonmotile primary cilium [GO:0097500]; response to hormone [GO:0009725]; retina development in camera-type eye [GO:0060041]; sensory perception of sound [GO:0007605]" GO:0005576; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005929; GO:0006910; GO:0007605; GO:0009725; GO:0032403; GO:0035091; GO:0045494; GO:0050766; GO:0060041; GO:0097500; GO:1903546 0 0 0 PF01167;PF16322; P55265 CHOYP_LOC584058.1.1 m.59244 sp DSRAD_HUMAN 45.387 542 262 9 637 1151 687 1221 4.21E-144 469 DSRAD_HUMAN reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) 1226 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337] GO:0001649; GO:0001701; GO:0002244; GO:0002566; GO:0003677; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006397; GO:0006606; GO:0006611; GO:0009615; GO:0016020; GO:0016553; GO:0030218; GO:0031054; GO:0035280; GO:0035455; GO:0043066; GO:0044387; GO:0044530; GO:0044822; GO:0045070; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060216; GO:0060337; GO:0060339; GO:0061484; GO:0098586; GO:1900369 0 0 0 PF02137;PF00035;PF02295; P79402 CHOYP_BRAFLDRAFT_61918.2.2 m.59433 sp CP242_PIG 42.13 216 115 5 2 209 99 312 4.21E-51 171 CP242_PIG reviewed Cytochrome P450 2C42 (EC 1.14.14.1) (CYPIIC42) (Fragment) CYP2C42 Sus scrofa (Pig) 327 epoxygenase P450 pathway [GO:0019373] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019373; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q059Y8 CHOYP_LOC590762.1.2 m.2158 sp DCST1_MOUSE 38.961 77 47 0 55 131 114 190 4.21E-10 59.7 DCST1_MOUSE reviewed DC-STAMP domain-containing protein 1 Dcst1 Mus musculus (Mouse) 732 0 GO:0016021; GO:0046872 0 0 0 PF07782; Q09654 CHOYP_LOC100368020.20.29 m.32904 sp TRI23_CAEEL 28.09 178 103 9 23 178 118 292 4.21E-06 50.1 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q19683 CHOYP_LOC100632210.1.1 m.30777 sp YZR5_CAEEL 44.025 159 88 1 18 176 247 404 4.21E-40 143 YZR5_CAEEL reviewed Uncharacterized protein F21D5.5 F21D5.5 Caenorhabditis elegans 407 DNA 3' dephosphorylation involved in DNA repair [GO:0098504]; polynucleotide 3' dephosphorylation [GO:0098506] GO:0003690; GO:0019201; GO:0046403; GO:0046404; GO:0098504; GO:0098506 0 0 0 PF08645; Q2T9K6 CHOYP_TVAG_096770.2.2 m.20869 sp FEM1C_XENLA 36.449 107 66 2 446 550 72 178 4.21E-10 66.2 FEM1C_XENLA reviewed Protein fem-1 homolog C (FEM1c) (FEM1-gamma) fem1c Xenopus laevis (African clawed frog) 617 protein ubiquitination [GO:0016567] GO:0005737; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q2YDL5 CHOYP_FKBP11.1.1 m.41644 sp FKB11_BOVIN 38.255 149 84 2 44 191 40 181 4.21E-23 95.1 FKB11_BOVIN reviewed Peptidyl-prolyl cis-trans isomerase FKBP11 (PPIase FKBP11) (EC 5.2.1.8) (FK506-binding protein 11) (FKBP-11) (Rotamase) FKBP11 Bos taurus (Bovine) 203 chaperone-mediated protein folding [GO:0061077] GO:0003755; GO:0005528; GO:0005789; GO:0016021; GO:0061077 0 0 0 PF00254; Q3SZQ6 CHOYP_BRAFLDRAFT_114866.5.5 m.65469 sp RL32_BOVIN 77.444 133 30 0 65 197 3 135 4.21E-73 219 RL32_BOVIN reviewed 60S ribosomal protein L32 RPL32 Bos taurus (Bovine) 135 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 cd00513; PF01655; Q4UMH6 CHOYP_TRPA1.1.2 m.22140 sp Y381_RICFE 24.615 390 248 11 682 1042 645 1017 4.21E-19 97.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5F478 CHOYP_AASI_1435.11.35 m.33068 sp ANR44_CHICK 30.572 857 544 10 120 926 11 866 4.21E-108 360 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q6ITT3 CHOYP_MGAT4C.1.1 m.37422 sp MGT4C_PIG 39.828 349 205 5 1 348 117 461 4.21E-80 255 MGT4C_PIG reviewed "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Sus scrofa (Pig) 478 N-glycan processing [GO:0006491] GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04666; Q6Q311 CHOYP_RS25.7.11 m.31143 sp RS25_SHEEP 74.725 91 23 0 37 127 33 123 4.21E-37 125 RS25_SHEEP reviewed 40S ribosomal protein S25 RPS25 Ovis aries (Sheep) 125 0 GO:0005840 0 0 0 PF03297; Q6UW60 CHOYP_PCSK4.1.2 m.53774 sp PCSK4_HUMAN 37.117 555 309 15 8 550 69 595 4.21E-104 334 PCSK4_HUMAN reviewed Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4) PCSK4 PC4 UNQ2757/PRO6496 Homo sapiens (Human) 755 acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240] GO:0001669; GO:0002080; GO:0004252; GO:0005615; GO:0007339; GO:0007340; GO:0009566; GO:0016021; GO:0016485; GO:0022414; GO:0048240 0 0 0 PF01483;PF00082;PF16470; Q7T010 CHOYP_GATB.1.1 m.10614 sp GATB_DANRE 48.283 495 248 5 17 506 61 552 4.21E-160 469 GATB_DANRE reviewed "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) (PET112-like)" gatb pet112 pet112l si:ch211-150a22.1 Danio rerio (Zebrafish) (Brachydanio rerio) 553 glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543] GO:0005524; GO:0005739; GO:0030956; GO:0032543; GO:0050567; GO:0070681 0 0 0 PF02934;PF02637; Q8BVD7 CHOYP_MFP1.1.1 m.47204 sp C1QT7_MOUSE 27.358 106 70 3 293 398 149 247 4.21E-06 51.6 C1QT7_MOUSE reviewed Complement C1q tumor necrosis factor-related protein 7 C1qtnf7 Ctrp7 Mus musculus (Mouse) 289 protein homooligomerization [GO:0051260] GO:0005581; GO:0005615; GO:0051260 0 0 0 PF00386;PF01391; Q8IXY8 CHOYP_BRAFLDRAFT_281480.1.1 m.22697 sp PPIL6_HUMAN 47.35 283 149 0 8 290 25 307 4.21E-100 298 PPIL6_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase-like 6 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL6) (Rotamase PPIL6) PPIL6 Homo sapiens (Human) 311 protein folding [GO:0006457] GO:0003755; GO:0006457 0 0 0 PF00160; Q8K0U4 CHOYP_HS12A.26.33 m.60378 sp HS12A_MOUSE 29.482 251 137 8 68 306 451 673 4.21E-24 105 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K203 CHOYP_NEIL3.3.3 m.57911 sp NEIL3_MOUSE 41.033 368 173 6 33 379 1 345 4.21E-88 281 NEIL3_MOUSE reviewed Endonuclease 8-like 3 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase FPG2) (DNA glycosylase/AP lyase Neil3) (Endonuclease VIII-like 3) (Nei-like protein 3) Neil3 Mus musculus (Mouse) 606 base-excision repair [GO:0006284]; nucleotide-excision repair [GO:0006289] GO:0000405; GO:0003684; GO:0003690; GO:0003697; GO:0003906; GO:0005634; GO:0005654; GO:0006284; GO:0006289; GO:0008270; GO:0019104 0 0 0 PF06831;PF06839;PF00641; Q8MJ08 CHOYP_BRAFLDRAFT_126347.2.2 m.34687 sp PE2R4_BOVIN 29.885 348 210 4 18 332 9 355 4.21E-47 174 PE2R4_BOVIN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Bos taurus (Bovine) 492 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cellular response to prostaglandin E stimulus [GO:0071380]; inflammatory response [GO:0006954]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0004957; GO:0005887; GO:0006954; GO:0007188; GO:0007189; GO:0007204; GO:0033624; GO:0050728; GO:0071380; GO:2000420 0 0 0 PF00001; Q99M01 CHOYP_SYFM.1.1 m.18632 sp SYFM_MOUSE 55.581 439 185 3 48 477 13 450 4.21E-178 509 SYFM_MOUSE reviewed "Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)" Fars2 Fars1 Mus musculus (Mouse) 451 phenylalanyl-tRNA aminoacylation [GO:0006432]; tRNA processing [GO:0008033] GO:0000049; GO:0000287; GO:0004826; GO:0005524; GO:0005739; GO:0005759; GO:0006432; GO:0008033 0 0 0 PF03147;PF01409; Q9IBD8 CHOYP_PTPRA.8.22 m.36817 sp PTPRC_CYPCA 54.839 93 37 3 240 331 562 650 4.21E-22 100 PTPRC_CYPCA reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45) ptprc Cyprinus carpio (Common carp) 1216 T cell receptor signaling pathway [GO:0050852] GO:0004725; GO:0016021; GO:0050852 0 0 0 PF00102; Q9UGM3 CHOYP_DMBT1.14.34 m.28053 sp DMBT1_HUMAN 30.812 714 344 28 3 583 297 993 4.21E-51 198 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A4IF63 CHOYP_BRAFLDRAFT_87269.3.8 m.33129 sp TRIM2_BOVIN 38.095 84 50 2 204 286 625 707 4.22E-09 60.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A7TNS8 CHOYP_WSB1.1.2 m.22464 sp CAF4_VANPO 38.235 68 38 1 55 122 533 596 4.22E-06 50.4 CAF4_VANPO reviewed CCR4-associated factor 4 homolog CAF4 Kpol_1016p11 Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) 669 mitochondrial fission [GO:0000266]; peroxisome fission [GO:0016559]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000266; GO:0005741; GO:0006357; GO:0016559; GO:0030014 0 0 0 PF00400; B0JZG0 CHOYP_S23A2.1.3 m.28545 sp S23A2_XENTR 45.671 462 239 5 27 483 190 644 4.22E-137 413 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; E9QAM5 CHOYP_LOC100368178.3.3 m.58853 sp HELZ2_MOUSE 28.947 380 235 13 458 826 1343 1698 4.22E-28 126 HELZ2_MOUSE reviewed Helicase with zinc finger domain 2 (EC 3.6.4.-) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) Helz2 Mus musculus (Mouse) 2947 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 O00401 CHOYP_NEMVEDRAFT_V1G241376.1.1 m.2268 sp WASL_HUMAN 41.975 81 46 1 54 134 406 485 4.22E-06 48.5 WASL_HUMAN reviewed Neural Wiskott-Aldrich syndrome protein (N-WASP) WASL Homo sapiens (Human) 505 "actin polymerization or depolymerization [GO:0008154]; cell division [GO:0051301]; cellular protein complex localization [GO:0034629]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; membrane budding [GO:0006900]; mitotic nuclear division [GO:0007067]; movement of cell or subcellular component [GO:0006928]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of membrane tubulation [GO:1903526]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of clathrin-mediated endocytosis [GO:2000370]; positive regulation of filopodium assembly [GO:0051491]; protein complex assembly [GO:0006461]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of protein localization [GO:0032880]; regulation of transcription, DNA-templated [GO:0006355]; response to bacterium [GO:0009617]; spindle localization [GO:0051653]; transcription, DNA-templated [GO:0006351]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050]" GO:0000139; GO:0005634; GO:0005829; GO:0005886; GO:0006351; GO:0006355; GO:0006461; GO:0006900; GO:0006928; GO:0007067; GO:0008154; GO:0009617; GO:0015629; GO:0016023; GO:0016050; GO:0030027; GO:0030050; GO:0030478; GO:0030666; GO:0030695; GO:0032880; GO:0034629; GO:0038096; GO:0048013; GO:0050999; GO:0051301; GO:0051491; GO:0051653; GO:0070062; GO:1903526; GO:2000370; GO:2000402; GO:2000601 0 0 0 PF00786;PF00568;PF02205; O88801 CHOYP_LOC100313636.3.3 m.45600 sp HOME2_RAT 42.01 388 173 6 233 615 3 343 4.22E-88 281 HOME2_RAT reviewed Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2) Homer2 Vesl2 Rattus norvegicus (Rat) 354 sensory perception of sound [GO:0007605] GO:0005730; GO:0005737; GO:0007605; GO:0014069; GO:0019904; GO:0030054; GO:0030425; GO:0032426; GO:0035254; GO:0035256; GO:0042803; GO:0043025; GO:0045211; GO:0046982 0 0 0 PF00568; P34416 CHOYP_LOC592472.1.1 m.36308 sp LASP1_CAEEL 42.105 152 75 3 12 163 67 205 4.22E-27 110 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P48034 CHOYP_ADO.1.1 m.43427 sp AOXA_BOVIN 35.081 248 127 8 47 265 145 387 4.22E-33 131 AOXA_BOVIN reviewed Aldehyde oxidase 1 (EC 1.2.3.1) (Azaheterocycle hydroxylase 1) (EC 1.17.3.-) AOX1 AO Bos taurus (Bovine) 1339 xanthine catabolic process [GO:0009115] GO:0004031; GO:0004854; GO:0005506; GO:0005829; GO:0009055; GO:0009115; GO:0016614; GO:0016903; GO:0043546; GO:0050660; GO:0051287; GO:0051537 0 0 0 PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; P58308 CHOYP_OX2R.1.3 m.5247 sp OX2R_MOUSE 28.979 421 249 10 7 387 1 411 4.22E-46 167 OX2R_MOUSE reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P70365 CHOYP_ISCW_ISCW017872.2.2 m.60293 sp NCOA1_MOUSE 43.768 345 178 7 27 364 32 367 4.22E-74 277 NCOA1_MOUSE reviewed Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Nuclear receptor coactivator protein 1) (mNRC-1) (Steroid receptor coactivator 1) (SRC-1) Ncoa1 Src1 Mus musculus (Mouse) 1447 "cellular response to hormone stimulus [GO:0032870]; cellular response to Thyroglobulin triiodothyronine [GO:1904017]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; estrous cycle [GO:0044849]; hippocampus development [GO:0021766]; histone H4 acetylation [GO:0043967]; hypothalamus development [GO:0021854]; labyrinthine layer morphogenesis [GO:0060713]; lactation [GO:0007595]; male gonad development [GO:0008584]; male mating behavior [GO:0060179]; positive regulation of apoptotic process [GO:0043065]; positive regulation of female receptivity [GO:0045925]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by galactose [GO:0000435]; regulation of cellular response to drug [GO:2001038]; regulation of RNA biosynthetic process [GO:2001141]; regulation of thyroid hormone mediated signaling pathway [GO:0002155]; response to estradiol [GO:0032355]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]; transcription, DNA-templated [GO:0006351]" GO:0000435; GO:0000790; GO:0001012; GO:0002155; GO:0003677; GO:0003682; GO:0003713; GO:0004402; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0007595; GO:0008134; GO:0008584; GO:0016922; GO:0019899; GO:0021549; GO:0021766; GO:0021854; GO:0021987; GO:0030374; GO:0032355; GO:0032526; GO:0032570; GO:0032870; GO:0035257; GO:0043005; GO:0043065; GO:0043967; GO:0044849; GO:0045666; GO:0045893; GO:0045925; GO:0045944; GO:0047485; GO:0060179; GO:0060713; GO:1904017; GO:2001038; GO:2001141 0 0 0 PF07469;PF00010;PF08815;PF00989;PF08832; P81018 CHOYP_BRAFLDRAFT_82587.1.1 m.51273 sp LADD_ONCMY 37.6 125 74 3 302 425 52 173 4.22E-19 88.2 LADD_ONCMY reviewed Ladderlectin 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 190 0 GO:0005615; GO:0005737; GO:0005829; GO:0005886; GO:0005903; GO:0008061; GO:0030246; GO:0044194 0 0 0 PF00059; Q0IH24 CHOYP_NEMVEDRAFT_V1G125875.3.3 m.65514 sp SPEF1_XENLA 39.689 257 115 5 15 265 4 226 4.22E-47 159 SPEF1_XENLA reviewed Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) 229 0 GO:0005737; GO:0005930 0 0 0 PF06294; Q16TM5 CHOYP_LOC100904495.1.1 m.34955 sp BND7A_AEDAE 69.903 103 27 1 18 120 23 121 4.22E-47 155 BND7A_AEDAE reviewed Band 7 protein AAEL010189 AAEL010189 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 297 0 GO:0016021 0 0 0 PF01145; Q28988 CHOYP_LOC100708320.1.1 m.17587 sp CYTA1_PIG 28.866 97 64 2 48 142 5 98 4.22E-11 58.9 CYTA1_PIG reviewed Cystatin-A1 (Stefin-A1) 0 Sus scrofa (Pig) 103 0 GO:0004869; GO:0005737 0 0 0 PF00031; Q3T0D0 CHOYP_BRAFLDRAFT_127356.1.2 m.8693 sp HNRPK_BOVIN 58.491 53 20 1 8 60 21 71 4.22E-09 55.1 HNRPK_BOVIN reviewed Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK Bos taurus (Bovine) 464 "mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045716]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [GO:0072369]; regulation of low-density lipoprotein particle clearance [GO:0010988]; RNA splicing [GO:0008380]" GO:0000790; GO:0000978; GO:0001077; GO:0002102; GO:0005654; GO:0005737; GO:0005925; GO:0006397; GO:0008380; GO:0010988; GO:0016020; GO:0042995; GO:0043066; GO:0044822; GO:0045716; GO:0048025; GO:0048260; GO:0070062; GO:0071013; GO:0072369; GO:1902165 0 0 0 PF00013;PF08067; Q4PM12 CHOYP_RPL36.1.1 m.57200 sp RL36_IXOSC 60.784 102 38 1 31 132 1 100 4.22E-38 127 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q5REG4 CHOYP_DTX3.3.3 m.64703 sp DTX3_PONAB 56.545 191 80 3 2296 2484 157 346 4.22E-63 223 DTX3_PONAB reviewed Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 347 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] GO:0005737; GO:0007219; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q5VY43 CHOYP_MEG11.19.25 m.56313 sp PEAR1_HUMAN 32.854 417 241 19 147 551 438 827 4.22E-40 159 PEAR1_HUMAN reviewed Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) PEAR1 MEGF12 Homo sapiens (Human) 1037 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q5ZI16 CHOYP_LOC100705296.1.1 m.31997 sp ADAT1_CHICK 47.414 232 114 5 297 524 257 484 4.22E-60 209 ADAT1_CHICK reviewed tRNA-specific adenosine deaminase 1 (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) ADAT1 RCJMB04_31g18 Gallus gallus (Chicken) 503 tRNA processing [GO:0008033] GO:0003723; GO:0008033; GO:0008251; GO:0046872 0 0 0 PF02137; Q61909 CHOYP_LOC100375491.1.1 m.11693 sp MTG8_MOUSE 46.488 598 238 14 12 561 3 566 4.22E-159 469 MTG8_MOUSE reviewed Protein CBFA2T1 (Protein MTG8) Runx1t1 Cbfa2t1 Cbfa2t1h Mtg8 Mus musculus (Mouse) 577 "fat cell differentiation [GO:0045444]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of DNA binding [GO:0051101]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003714; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0006351; GO:0006355; GO:0010977; GO:0016363; GO:0017053; GO:0042803; GO:0045444; GO:0045599; GO:0045892; GO:0046872; GO:0051101 0 0 0 PF08788;PF07531;PF01753; Q66S03 CHOYP_SI_DKEYP-75B4.10.1.2 m.39116 sp LECG_THANI 33.663 101 63 3 40 139 36 133 4.22E-11 64.7 LECG_THANI reviewed Galactose-specific lectin nattectin (CTL) 0 Thalassophryne nattereri (Niquim) 159 inflammatory response [GO:0006954] GO:0005576; GO:0006954; GO:0030246; GO:0046872 0 0 0 PF00059; Q6DIB5 CHOYP_MEGF6.2.59 m.1836 sp MEG10_MOUSE 37.447 235 121 13 154 382 268 482 4.22E-23 106 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6P2C0 CHOYP_LOC100370122.1.2 m.6529 sp WDR93_HUMAN 25.204 734 472 17 2 721 15 685 4.22E-70 246 WDR93_HUMAN reviewed WD repeat-containing protein 93 WDR93 Homo sapiens (Human) 686 electron transport chain [GO:0022900] GO:0016651; GO:0022900 0 0 0 0 Q6ZMQ8 CHOYP_LOC100679044.1.2 m.62979 sp LMTK1_HUMAN 35.529 425 215 17 7 414 32 414 4.22E-62 234 LMTK1_HUMAN reviewed Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) AATK AATYK KIAA0641 LMR1 LMTK1 Homo sapiens (Human) 1374 0 GO:0004674; GO:0005524; GO:0016021; GO:0048471 0 0 0 PF07714; Q863Y9 CHOYP_LOC100010471.1.1 m.8649 sp GTR5_HORSE 44.886 176 85 1 15 190 8 171 4.22E-42 150 GTR5_HORSE reviewed "Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)" SLC2A5 GLUT5 Equus caballus (Horse) 501 cellular response to fructose stimulus [GO:0071332]; fructose import across plasma membrane [GO:1990539]; fructose transport [GO:0015755]; regulation of systemic arterial blood pressure mediated by a chemical signal [GO:0003044]; response to fructose [GO:0009750] GO:0003044; GO:0005353; GO:0005887; GO:0009750; GO:0015755; GO:0016324; GO:0042383; GO:0070061; GO:0070062; GO:0071332; GO:1990539 0 0 cd06174; PF00083; Q9Y0A7 CHOYP_LOC100868136.1.1 m.36568 sp AMOS_DROME 70.313 64 19 0 131 194 134 197 4.22E-23 94.4 AMOS_DROME reviewed Basic helix-loop-helix transcription factor amos (Absent MD neurons and olfactory sensilla protein) (Amos protein) (Reduced olfactory organs protein) (Rough eye protein) amos Roi rolo CG10393 Drosophila melanogaster (Fruit fly) 198 "dendrite morphogenesis [GO:0048813]; regulation of transcription, DNA-templated [GO:0006355]; sensory organ boundary specification [GO:0008052]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007423; GO:0008052; GO:0016360; GO:0046982; GO:0048813 0 0 0 PF00010; O70277 CHOYP_TRIM3A.1.1 m.53280 sp TRIM3_RAT 26.573 286 189 11 85 357 465 742 4.23E-14 77 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_TVAG_227760.4.4 m.65849 sp ANR17_HUMAN 42.021 188 101 5 3 184 496 681 4.23E-29 116 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O88801 CHOYP_LOC100313636.1.3 m.1152 sp HOME2_RAT 44.759 353 178 4 185 532 3 343 4.23E-94 294 HOME2_RAT reviewed Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2) Homer2 Vesl2 Rattus norvegicus (Rat) 354 sensory perception of sound [GO:0007605] GO:0005730; GO:0005737; GO:0007605; GO:0014069; GO:0019904; GO:0030054; GO:0030425; GO:0032426; GO:0035254; GO:0035256; GO:0042803; GO:0043025; GO:0045211; GO:0046982 0 0 0 PF00568; P19623 CHOYP_LOC100641892.1.1 m.56601 sp SPEE_HUMAN 53.979 289 133 0 2 290 14 302 4.23E-120 349 SPEE_HUMAN reviewed Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase) SRM SPS1 SRML1 Homo sapiens (Human) 302 polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295] GO:0004766; GO:0005829; GO:0006595; GO:0008295; GO:0042803 PATHWAY: Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. 0 0 0 P25666 CHOYP_NEMVEDRAFT_V1G214498.6.12 m.11954 sp HTRL_ECOLI 23.256 301 147 11 80 337 3 262 4.23E-07 54.3 HTRL_ECOLI reviewed Protein HtrL htrL yibB b3618 JW5644 Escherichia coli (strain K12) 285 lipopolysaccharide biosynthetic process [GO:0009103] GO:0009103 0 0 0 PF09612; P27393 CHOYP_CBR-LET-2.1.2 m.37496 sp CO4A2_ASCSU 33.788 293 155 7 1 290 1078 1334 4.23E-08 58.2 CO4A2_ASCSU reviewed Collagen alpha-2(IV) chain 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 1763 0 GO:0005201; GO:0005581; GO:0005604 0 0 0 PF01413;PF01391; P27393 CHOYP_CO4A2.1.2 m.14632 sp CO4A2_ASCSU 33.788 293 155 7 1 290 1078 1334 4.23E-08 58.2 CO4A2_ASCSU reviewed Collagen alpha-2(IV) chain 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 1763 0 GO:0005201; GO:0005581; GO:0005604 0 0 0 PF01413;PF01391; P51814 CHOYP_ZN33A.1.1 m.9101 sp ZNF41_HUMAN 36.09 133 78 4 2 134 430 555 4.23E-16 77 ZNF41_HUMAN reviewed Zinc finger protein 41 ZNF41 Homo sapiens (Human) 821 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q5PQ30 CHOYP_T2AG.1.1 m.6204 sp LYSM1_XENLA 30.455 220 99 8 52 258 37 215 4.23E-17 80.5 LYSM1_XENLA reviewed LysM and putative peptidoglycan-binding domain-containing protein 1 lysmd1 Xenopus laevis (African clawed frog) 215 0 0 0 0 0 PF01476; Q5RC46 CHOYP_BRAFLDRAFT_219059.1.1 m.40577 sp CECR1_PONAB 44.338 521 263 5 2 521 11 505 4.23E-154 453 CECR1_PONAB reviewed Adenosine deaminase CECR1 (EC 3.5.4.4) (Cat eye syndrome critical region protein 1) CECR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 511 adenosine catabolic process [GO:0006154] GO:0004000; GO:0005615; GO:0006154; GO:0008201; GO:0008270; GO:0031685; GO:0043394 0 0 0 PF00962;PF08451; Q5VU97 CHOYP_NEMVEDRAFT_V1G238894.3.11 m.42682 sp CAHD1_HUMAN 26.628 1044 679 36 26 1007 45 1063 4.23E-88 312 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6AXU6 CHOYP_HN1L.1.2 m.7161 sp HN1_RAT 50 54 26 1 1 53 1 54 4.23E-06 47.8 HN1_RAT reviewed "Hematological and neurological expressed 1 protein [Cleaved into: Hematological and neurological expressed 1 protein, N-terminally processed]" Hn1 Rattus norvegicus (Rat) 149 0 GO:0005730; GO:0031965 0 0 0 PF17054; Q6NT55 CHOYP_LOC100375647.2.2 m.63362 sp CP4FN_HUMAN 47.794 272 134 3 6 270 250 520 4.23E-84 264 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q6ZQ03 CHOYP_LOC100376642.1.1 m.19616 sp FNBP4_MOUSE 44.118 102 46 2 120 210 522 623 4.23E-19 89.7 FNBP4_MOUSE reviewed Formin-binding protein 4 (Formin-binding protein 30) Fnbp4 Fbp30 Kiaa1014 Mus musculus (Mouse) 1031 0 GO:0005654 0 0 0 PF00397; Q7YS61 CHOYP_TRDMT1.1.1 m.11388 sp TRDMT_BOVIN 38.731 457 202 9 1 450 4 389 4.23E-97 300 TRDMT_BOVIN reviewed tRNA (cytosine-5-)-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Dnmt2) TRDMT1 DNMT2 Bos taurus (Bovine) 391 0 GO:0003723; GO:0005634; GO:0005737; GO:0008175 0 0 0 PF00145; Q803V5 CHOYP_LOC100376733.1.1 m.12140 sp LST8_DANRE 69.085 317 91 1 7 316 9 325 4.23E-175 490 LST8_DANRE reviewed "Target of rapamycin complex subunit lst8 (TORC subunit lst8) (G protein beta subunit-like) (Gable) (Protein GbetaL) (MTOR associated protein, LST8 homolog)" mlst8 gbl lst8 zgc:55455 zgc:85668 Danio rerio (Zebrafish) (Brachydanio rerio) 326 0 GO:0005737 0 0 0 PF00400; Q80VJ2 CHOYP_SRA1.1.1 m.56432 sp SRA1_MOUSE 35.294 102 64 1 70 169 105 206 4.23E-14 72.4 SRA1_MOUSE reviewed Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP) Sra1 Mus musculus (Mouse) 232 "apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005831; GO:0005886; GO:0006351; GO:0006357; GO:0006915; GO:0008283; GO:0010861; GO:0015630; GO:0030154; GO:0030374; GO:0030529; GO:0031252; GO:0042981; GO:0045171; GO:0045944 0 0 0 PF07304; Q80WQ8 CHOYP_MIS18BP1.1.1 m.15654 sp M18BP_MOUSE 27.863 262 154 11 675 913 746 995 4.23E-17 90.1 M18BP_MOUSE reviewed Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) Mis18bp1 Kiaa1903 Knl2 M18bp1 Mus musculus (Mouse) 998 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0000778; GO:0003677; GO:0007067; GO:0051301 0 0 0 PF00249;PF09133; Q92035 CHOYP_NEMVEDRAFT_V1G241380.1.1 m.29606 sp ACES_BUNFA 30.965 549 338 16 33 560 40 568 4.23E-76 257 ACES_BUNFA reviewed Acetylcholinesterase (AChE) (EC 3.1.1.7) ACHE Bungarus fasciatus (Banded krait) (Pseudoboa fasciata) 606 acetylcholine catabolic process in synaptic cleft [GO:0001507] GO:0001507; GO:0003990; GO:0005886; GO:0030054; GO:0043083 0 0 0 PF08674;PF00135; Q92539 CHOYP_DWIL_GK23042.1.1 m.38792 sp LPIN2_HUMAN 44.022 552 253 12 311 854 387 890 4.23E-131 428 LPIN2_HUMAN reviewed Phosphatidate phosphatase LPIN2 (EC 3.1.3.4) (Lipin-2) LPIN2 KIAA0249 Homo sapiens (Human) 896 "fatty acid catabolic process [GO:0009062]; lipid metabolic process [GO:0006629]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]; triglyceride biosynthetic process [GO:0019432]" GO:0003713; GO:0005634; GO:0005789; GO:0005829; GO:0006351; GO:0006629; GO:0006646; GO:0006656; GO:0008195; GO:0009062; GO:0019432; GO:0045944 0 0 0 PF16876;PF04571;PF08235; Q9DBF7 CHOYP_LOC577351.1.1 m.17664 sp CWC25_MOUSE 36.364 132 70 3 489 618 297 416 4.23E-10 65.9 CWC25_MOUSE reviewed Pre-mRNA-splicing factor CWC25 homolog (Coiled-coil domain-containing protein 49) (Spliceosome-associated protein homolog CWC25) Cwc25 Ccdc49 Mus musculus (Mouse) 416 0 GO:0005654 0 0 0 PF10197;PF12542; Q9UJV3 CHOYP_LOC100374741.12.83 m.14893 sp TRIM1_HUMAN 29.339 242 117 9 10 215 23 246 4.23E-16 85.9 TRIM1_HUMAN reviewed Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (Tripartite motif-containing protein 1) MID2 FXY2 RNF60 TRIM1 Homo sapiens (Human) 735 innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567] GO:0005737; GO:0005874; GO:0008017; GO:0008270; GO:0010508; GO:0016567; GO:0016874; GO:0032897; GO:0035372; GO:0042803; GO:0043123; GO:0045087; GO:0046597; GO:0046982; GO:0051091; GO:0051092; GO:0051219; GO:0070062; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622;PF00643;PF13445; B1AQJ2 CHOYP_USP36.1.2 m.17402 sp UBP36_MOUSE 45.808 489 239 6 12 476 7 493 4.24E-142 458 UBP36_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) Usp36 Kiaa1453 Mus musculus (Mouse) 1098 positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; regulation of mitophagy [GO:1903146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005634; GO:0005730; GO:0006511; GO:0016579; GO:0044822; GO:1903146; GO:1903955 0 0 0 PF00443; B3EWZ6 CHOYP_CORIN.1.2 m.39888 sp MLRP2_ACRMI 32.979 282 162 13 84 351 5726 5994 4.24E-24 107 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B4PEU8 CHOYP_LOC100703866.1.2 m.44330 sp RS9_DROYA 85.714 182 26 0 19 200 2 183 4.24E-108 324 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; O60304 CHOYP_ZFP41.1.1 m.13273 sp ZN500_HUMAN 39.623 106 61 3 623 728 325 427 4.24E-15 82 ZN500_HUMAN reviewed Zinc finger protein 500 (Zinc finger protein with KRAB and SCAN domains 18) ZNF500 KIAA0557 ZKSCAN18 Homo sapiens (Human) 480 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0043565; GO:0046872 0 0 cd07765; PF01352;PF02023;PF00096;PF13912; P02594 CHOYP_CALM.21.50 m.30984 sp CALM_ELEEL 56.081 148 64 1 13 160 1 147 4.24E-51 163 CALM_ELEEL reviewed Calmodulin (CaM) calm Electrophorus electricus (Electric eel) (Gymnotus electricus) 149 0 GO:0005509 0 0 0 PF13499; P08021 CHOYP_FMRF.1.4 m.26285 sp FMRF_APLCA 47.047 491 143 24 1 432 1 433 4.24E-84 272 FMRF_APLCA reviewed FMRF-amide neuropeptides [Cleaved into: FLRF-amide; FMRF-amide] 0 Aplysia californica (California sea hare) 597 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF01581; P10079 CHOYP_SNED1.1.4 m.27935 sp FBP1_STRPU 42.121 330 164 13 132 457 636 942 4.24E-57 211 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P17972 CHOYP_KCNC4.3.5 m.49537 sp KCNAW_DROME 30.377 451 260 8 76 512 10 420 4.24E-62 217 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P39242 CHOYP_ACA1_027810.1.1 m.41685 sp Y05G_BPT4 24.812 133 89 3 219 340 2 134 4.24E-06 52 Y05G_BPT4 reviewed Uncharacterized 38.9 kDa protein in nrdC-mobD intergenic region y05G nrdC.11 tk.-11 Enterobacteria phage T4 (Bacteriophage T4) 336 0 0 0 0 0 PF10127; P41386 CHOYP_TUB1.1.1 m.3492 sp TBB_HALDI 88.636 132 14 1 106 236 79 210 4.24E-79 244 TBB_HALDI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Haliotis discus (Abalone) (Nordotis discus) 341 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P42026 CHOYP_LOC732995.1.2 m.36032 sp NDUS7_BOVIN 64.815 108 32 1 41 148 38 139 4.24E-44 147 NDUS7_BOVIN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) 216 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005747; GO:0008137; GO:0032981; GO:0046872; GO:0048038; GO:0051539 0 0 0 PF01058; P58308 CHOYP_LOC100647787.1.1 m.43892 sp OX2R_MOUSE 29.581 382 236 8 26 388 33 400 4.24E-43 159 OX2R_MOUSE reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Mox2r Mus musculus (Mouse) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; Q0E908 CHOYP_LOC656867.1.1 m.28659 sp HIL_DROME 30.07 286 171 7 21 292 1 271 4.24E-35 137 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q1HPL8 CHOYP_TSP_01008.1.3 m.909 sp NDUBA_BOMMO 40.566 106 63 0 9 114 45 150 4.24E-23 90.9 NDUBA_BOMMO reviewed NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0 Bombyx mori (Silk moth) 159 oxidation-reduction process [GO:0055114] GO:0005743; GO:0055114; GO:0070469 0 0 0 PF10249; Q1ZXD6 CHOYP_BRAFLDRAFT_79758.3.3 m.66708 sp ROCO5_DICDI 23.047 256 147 7 246 487 1342 1561 4.24E-09 64.7 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q2VY69 CHOYP_ZSCA2.2.2 m.23502 sp ZN284_HUMAN 34.932 146 89 3 85 228 255 396 4.24E-18 86.7 ZN284_HUMAN reviewed Zinc finger protein 284 ZNF284 ZNF284L Homo sapiens (Human) 593 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q3SZ21 CHOYP_LOC579142.1.1 m.28459 sp RPP30_BOVIN 38.71 248 133 6 17 260 4 236 4.24E-44 154 RPP30_BOVIN reviewed Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2) RPP30 RNASEP2 Bos taurus (Bovine) 268 "RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; tRNA processing [GO:0008033]" GO:0003723; GO:0004526; GO:0005655; GO:0008033; GO:0090502 0 0 0 PF01876; Q53G44 CHOYP_LOC100377780.9.11 m.56593 sp IF44L_HUMAN 26.667 135 99 0 189 323 292 426 4.24E-10 63.9 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q569L8 CHOYP_CENPJ.1.1 m.49318 sp CENPJ_MOUSE 46.655 568 208 13 816 1366 852 1341 4.24E-138 460 CENPJ_MOUSE reviewed Centromere protein J (CENP-J) Cenpj Mus musculus (Mouse) 1344 astral microtubule nucleation [GO:0030954]; cell division [GO:0051301]; centriole assembly [GO:0098534]; centriole elongation [GO:0061511]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; microtubule polymerization [GO:0046785]; mitotic spindle pole body duplication [GO:1903087]; motile primary cilium assembly [GO:1903887]; nonmotile primary cilium assembly [GO:0035058]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of nonmotile primary cilium assembly [GO:1902857]; regulation of centriole replication [GO:0046599]; smoothened signaling pathway [GO:0007224] GO:0003713; GO:0005737; GO:0005813; GO:0005814; GO:0005874; GO:0007099; GO:0007224; GO:0015631; GO:0019901; GO:0019904; GO:0030954; GO:0035058; GO:0036064; GO:0043015; GO:0046427; GO:0046599; GO:0046785; GO:0051298; GO:0051301; GO:0061511; GO:0098534; GO:1902857; GO:1903087; GO:1903887 0 0 0 PF07202; Q5M8Z2 CHOYP_PREY.1.2 m.22290 sp PREY_XENTR 57.333 75 30 1 27 101 48 120 4.24E-22 86.7 PREY_XENTR reviewed "Protein preY, mitochondrial" pyurf pigy prey Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 122 0 GO:0005739 0 0 0 PF03966; Q5ND28 CHOYP_MEG10.7.91 m.17998 sp SREC_MOUSE 40.397 151 86 4 175 325 214 360 4.24E-21 97.8 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5R9K8 CHOYP_LOC100367381.2.2 m.26689 sp AR2BP_PONAB 62.329 146 55 0 14 159 3 148 4.24E-60 187 AR2BP_PONAB reviewed ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) ARL2BP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 163 maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517] GO:0003713; GO:0005634; GO:0005758; GO:0005813; GO:0005819; GO:0005929; GO:0030496; GO:0042517; GO:0051457 0 0 0 PF11527; Q5U465 CHOYP_LOC101068326.1.1 m.16878 sp CC125_MOUSE 29.855 345 216 7 82 420 101 425 4.24E-33 133 CC125_MOUSE reviewed Coiled-coil domain-containing protein 125 Ccdc125 Kenae Mus musculus (Mouse) 500 0 GO:0005737 0 0 0 0 Q5U5M8 CHOYP_BRAFLDRAFT_129004.15.15 m.60150 sp BL1S3_MOUSE 28.877 187 112 5 7 182 13 189 4.24E-10 59.7 BL1S3_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) (Reduced pigmentation protein) Bloc1s3 Blos3 Rp Mus musculus (Mouse) 195 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; developmental pigmentation [GO:0048066]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; pigmentation [GO:0043473]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to drug [GO:0042493]; secretion of lysosomal enzymes [GO:0033299] GO:0001654; GO:0005737; GO:0005829; GO:0007596; GO:0008089; GO:0008320; GO:0016197; GO:0030133; GO:0030168; GO:0031083; GO:0031175; GO:0032402; GO:0032438; GO:0032816; GO:0033299; GO:0035646; GO:0042493; GO:0043473; GO:0048066; GO:0048490; GO:0060155; GO:1904115 0 0 0 PF15753; Q5XM24 CHOYP_BRAFLDRAFT_121045.1.1 m.55827 sp APRA_DICDI 35.537 484 284 13 14 480 13 485 4.24E-98 307 APRA_DICDI reviewed Autocrine proliferation repressor protein A (PhoPQ-activated pathogenicity-related protein) aprA DDB_G0281663 Dictyostelium discoideum (Slime mold) 494 cell cycle [GO:0007049]; negative chemotaxis [GO:0050919]; negative regulation of asexual reproduction [GO:1903665]; protein localization to plasma membrane [GO:0072659]; regulation of aggregate size involved in sorocarp development [GO:0031157]; sporulation resulting in formation of a cellular spore [GO:0030435] GO:0005102; GO:0005576; GO:0005622; GO:0007049; GO:0030435; GO:0031157; GO:0043234; GO:0045499; GO:0050919; GO:0072659; GO:1903665 0 0 0 PF10142; Q60467 CHOYP_NB001.1.1 m.19980 sp CO5A1_CRILO 55.435 92 34 2 58 143 835 925 4.24E-10 61.2 CO5A1_CRILO reviewed Collagen alpha-1(V) chain COL5A1 Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) 1840 0 GO:0005201; GO:0005578; GO:0005581; GO:0008201 0 0 0 PF01410;PF01391; Q7Z591 CHOYP_LOC756958.1.2 m.17672 sp AKNA_HUMAN 28.846 260 155 7 565 815 427 665 4.24E-21 105 AKNA_HUMAN reviewed AT-hook-containing transcription factor AKNA KIAA1968 Homo sapiens (Human) 1439 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0005634; GO:0016020; GO:0045944 0 0 0 PF12443; Q7ZU45 CHOYP_LOC100372889.2.2 m.57965 sp TTC25_DANRE 47.667 493 232 4 19 504 13 486 4.24E-155 459 TTC25_DANRE reviewed Tetratricopeptide repeat protein 25 (TPR repeat protein 25) ttc25 Danio rerio (Zebrafish) (Brachydanio rerio) 486 cilium assembly [GO:0042384]; determination of heart left/right asymmetry [GO:0061371]; otolith morphogenesis [GO:0032474] GO:0032474; GO:0042384; GO:0061371 0 0 0 0 Q86U86 CHOYP_ISCW_ISCW005293.1.1 m.44943 sp PB1_HUMAN 35.461 141 71 4 53 193 1341 1461 4.24E-15 80.1 PB1_HUMAN reviewed Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 "chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0003682; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0008285; GO:0016569; GO:0090544 0 0 0 PF01426;PF00439;PF00505; Q8BK48 CHOYP_LOC100922782.1.1 m.5582 sp EST2E_MOUSE 34.838 554 305 17 31 569 36 548 4.24E-85 278 EST2E_MOUSE reviewed Pyrethroid hydrolase Ces2e (EC 3.1.1.88) (carboxylesterase 2E) Ces2e Ces5 Mus musculus (Mouse) 559 0 GO:0005615; GO:0005783; GO:0052689; GO:0102209 0 0 0 PF00135; Q8R151 CHOYP_LOC100536767.1.2 m.14493 sp ZNFX1_MOUSE 47.314 484 236 7 260 739 912 1380 4.24E-129 425 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R2M2 CHOYP_LOC100560380.1.1 m.26993 sp TDIF2_MOUSE 51.111 180 73 3 90 269 573 737 4.24E-53 188 TDIF2_MOUSE reviewed Deoxynucleotidyltransferase terminal-interacting protein 2 Dnttip2 Mus musculus (Mouse) 758 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005730; GO:0006351; GO:0006355; GO:0044822 0 0 0 PF08698; Q96WM9 CHOYP_LOC100206475.2.16 m.4855 sp LAC2_BOTFU 44.444 63 32 2 73 134 73 133 4.24E-06 48.1 LAC2_BOTFU reviewed Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Urishiol oxidase 2) lcc2 Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) 581 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q9BZE7 CHOYP_LOC100372365.2.2 m.52024 sp EVG1_HUMAN 42.512 207 105 6 24 225 13 210 4.24E-42 145 EVG1_HUMAN reviewed UPF0193 protein EVG1 C22orf23 Homo sapiens (Human) 217 0 0 0 0 0 PF05250; Q9LQV2 CHOYP_BRAFLDRAFT_99723.4.9 m.37088 sp RDR1_ARATH 41.284 436 226 10 38 462 681 1097 4.24E-80 288 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; Q9UPM9 CHOYP_LOC100561894.1.1 m.45815 sp B9D1_HUMAN 67.742 186 60 0 2 187 4 189 4.24E-99 288 B9D1_HUMAN reviewed B9 domain-containing protein 1 (MKS1-related protein 1) B9D1 MKSR1 Homo sapiens (Human) 204 camera-type eye development [GO:0043010]; cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944] GO:0001701; GO:0001944; GO:0005813; GO:0005829; GO:0007224; GO:0008158; GO:0016020; GO:0032880; GO:0035869; GO:0036038; GO:0036064; GO:0042384; GO:0042733; GO:0043010; GO:0060271; GO:0060563 0 0 0 PF07162; G3I6Z6 CHOYP_NEMVEDRAFT_V1G141380.1.4 m.8972 sp NOTC1_CRIGR 39.899 198 106 6 2 198 750 935 4.25E-34 131 NOTC1_CRIGR reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 2527 "angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; Notch signaling involved in heart development [GO:0061314]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000139; GO:0001525; GO:0004872; GO:0005509; GO:0005634; GO:0005796; GO:0005912; GO:0006351; GO:0006355; GO:0016021; GO:0016324; GO:0030154; GO:0050793; GO:0060271; GO:0061314 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; O95825 CHOYP_NEMVEDRAFT_V1G168923.1.1 m.29344 sp QORL1_HUMAN 41.003 339 194 2 10 348 11 343 4.25E-85 264 QORL1_HUMAN reviewed Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Protein 4P11) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog) CRYZL1 4P11 Homo sapiens (Human) 349 quinone metabolic process [GO:1901661] GO:0003960; GO:0005829; GO:0008270; GO:0050661; GO:1901661 0 0 0 0 P0C2C1 CHOYP_SMP_102490.1.2 m.22219 sp RM30_RAT 40.206 97 52 2 21 117 63 153 4.25E-14 69.7 RM30_RAT reviewed "39S ribosomal protein L30, mitochondrial (L30mt) (MRP-L30)" Mrpl30 Rattus norvegicus (Rat) 160 0 GO:0005739; GO:0005840 0 0 cd01658; PF00327; P23403 CHOYP_XPP1.2.2 m.38698 sp RS20_XENLA 88.034 117 12 2 4 118 3 119 4.25E-64 193 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P28573 CHOYP_BRAFLDRAFT_117178.1.1 m.28349 sp SC6A7_RAT 46.763 139 73 1 5 142 4 142 4.25E-44 155 SC6A7_RAT reviewed Sodium-dependent proline transporter (Solute carrier family 6 member 7) Slc6a7 Rattus norvegicus (Rat) 637 proline transport [GO:0015824] GO:0005328; GO:0005887; GO:0015193; GO:0015824 0 0 0 PF00209; P42674 CHOYP_LOC593467.2.4 m.66724 sp BP10_PARLI 33.25 400 233 13 154 544 71 445 4.25E-56 202 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; Q05695 CHOYP_LOC100167385.1.1 m.62276 sp L1CAM_RAT 25.298 419 262 19 52 446 52 443 4.25E-23 107 L1CAM_RAT reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (Nerve-growth factor-inducible large external glycoprotein) (NILE) (CD antigen CD171) L1cam Caml1 Rattus norvegicus (Rat) 1259 cell adhesion [GO:0007155]; cellular response to ethanol [GO:0071361]; cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of axon extension [GO:0045773] GO:0005768; GO:0005886; GO:0007155; GO:0009986; GO:0016021; GO:0030165; GO:0030424; GO:0030425; GO:0043025; GO:0044295; GO:0045121; GO:0045773; GO:0071361; GO:0071560 0 0 0 PF13882;PF00041;PF07679; Q15399 CHOYP_BRAFLDRAFT_89683.2.5 m.25773 sp TLR1_HUMAN 39.252 107 62 3 62 167 636 740 4.25E-11 68.9 TLR1_HUMAN reviewed Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) 786 cellular response to triacyl bacterial lipopeptide [GO:0071727]; defense response to bacterium [GO:0042742]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; toll-like receptor 1 signaling pathway [GO:0034130]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0016020; GO:0030670; GO:0034130; GO:0035354; GO:0035663; GO:0038123; GO:0042116; GO:0042495; GO:0042535; GO:0042742; GO:0045087; GO:0045121; GO:0045410; GO:0046982; GO:0050707; GO:0071723; GO:0071727 0 0 0 PF13855;PF01463;PF01582; Q5RBU8 CHOYP_LOC100748395.5.7 m.57890 sp ROA2_PONAB 53.684 190 88 0 17 206 16 205 4.25E-67 214 ROA2_PONAB reviewed Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 353 "miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; primary miRNA processing [GO:0031053]" GO:0000166; GO:0000398; GO:0003730; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006406; GO:0030529; GO:0031053; GO:0035198; GO:0043047; GO:0070062; GO:1990247; GO:1990428 0 0 0 PF00076; Q61555 CHOYP_LOC100877035.1.1 m.9440 sp FBN2_MOUSE 47.236 199 100 4 1 198 1803 1997 4.25E-47 168 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q6DIB5 CHOYP_MEGF10.11.12 m.47520 sp MEG10_MOUSE 38.801 317 164 15 66 372 400 696 4.25E-42 160 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q8C8H8 CHOYP_SMP_051990.7.7 m.57569 sp KY_MOUSE 26.087 207 140 6 17 215 457 658 4.25E-10 62 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8IV20 CHOYP_LOC100769755.1.1 m.59793 sp LACC1_HUMAN 39.65 343 183 10 75 398 92 429 4.25E-70 229 LACC1_HUMAN reviewed Laccase domain-containing protein 1 LACC1 C13orf31 Homo sapiens (Human) 430 0 GO:0005507 0 0 0 PF02578; Q8K0U4 CHOYP_HS12A.19.33 m.54914 sp HS12A_MOUSE 32.394 639 349 20 939 1514 55 673 4.25E-85 296 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N584 CHOYP_TT39C.1.1 m.6317 sp TT39C_HUMAN 46.835 553 286 4 22 567 27 578 4.25E-180 523 TT39C_HUMAN reviewed Tetratricopeptide repeat protein 39C (TPR repeat protein 39C) TTC39C C18orf17 Homo sapiens (Human) 583 0 0 0 0 0 PF10300; Q96JP0 CHOYP_LOC100641396.1.27 m.3197 sp FEM1C_HUMAN 43.478 92 50 2 498 587 85 176 4.25E-13 75.9 FEM1C_HUMAN reviewed Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) 617 protein ubiquitination [GO:0016567] GO:0005654; GO:0005737; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q9GNE2 CHOYP_PHUM_PHUM465850.1.2 m.41267 sp RL23_AEDAE 85.321 109 9 2 1 109 1 102 4.25E-58 179 RL23_AEDAE reviewed 60S ribosomal protein L23 (AeRpL17A) (L17A) RpL23-A RpL17A AAEL013097; RpL23-B AAEL013583; RpL23-C AAEL015006 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 140 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00238; Q9VCA8 CHOYP_LOC100641396.14.27 m.39285 sp ANKHM_DROME 32.93 413 239 15 3 387 632 1034 4.25E-41 159 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; D3YXG0 CHOYP_BRAFLDRAFT_123537.1.2 m.28822 sp HMCN1_MOUSE 29.124 388 251 13 205 576 2863 3242 4.26E-32 137 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O70480 CHOYP_LOC100081619.1.1 m.33744 sp VAMP4_MOUSE 48.739 119 58 3 1 118 1 117 4.26E-27 101 VAMP4_MOUSE reviewed Vesicle-associated membrane protein 4 (VAMP-4) Vamp4 Mus musculus (Mouse) 141 exocytosis [GO:0006887]; Golgi ribbon formation [GO:0090161]; Golgi to plasma membrane protein transport [GO:0043001]; microtubule cytoskeleton organization [GO:0000226]; regulation of Golgi to plasma membrane protein transport [GO:0042996]; SNARE complex assembly [GO:0035493]; toxin transport [GO:1901998]; vesicle fusion [GO:0006906] GO:0000149; GO:0000226; GO:0005484; GO:0005794; GO:0005802; GO:0006887; GO:0006906; GO:0009986; GO:0016021; GO:0031201; GO:0035493; GO:0042996; GO:0043001; GO:0090161; GO:1901998 0 0 0 PF00957; O88281 CHOYP_LOC100370489.2.4 m.41538 sp MEGF6_RAT 31.579 969 572 36 189 1116 634 1552 4.26E-89 325 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P14078 CHOYP_LOC100494344.2.3 m.46870 sp POL_HTL1C 25.161 310 189 11 106 406 591 866 4.26E-07 57 POL_HTL1C reviewed Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] gag-pro-pol Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) 1462 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; suppression by virus of host gene expression [GO:0039657]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0005198; GO:0006310; GO:0008270; GO:0015074; GO:0019013; GO:0039657; GO:0046718; GO:0075713 0 0 0 PF02228;PF00607;PF00552;PF02022;PF00075;PF00665;PF00077;PF00078;PF00098; P21758 CHOYP_DMBT1.2.34 m.3482 sp MSRE_BOVIN 51.429 105 50 1 61 165 348 451 4.26E-29 117 MSRE_BOVIN reviewed Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (CD antigen CD204) MSR1 Bos taurus (Bovine) 453 cholesterol transport [GO:0030301]; lipoprotein transport [GO:0042953]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of macrophage derived foam cell differentiation [GO:0010744] GO:0005044; GO:0005581; GO:0010744; GO:0010886; GO:0016021; GO:0030169; GO:0030301; GO:0034362; GO:0034381; GO:0042953 0 0 0 PF01391;PF03523;PF00530; P28827 CHOYP_PTPRM.10.15 m.52051 sp PTPRM_HUMAN 29.583 480 304 15 1 461 985 1449 4.26E-50 187 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P78560 CHOYP_LRDD.2.2 m.32344 sp CRADD_HUMAN 23.684 76 58 0 11 86 115 190 4.26E-07 48.9 CRADD_HUMAN reviewed Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) CRADD RAIDD Homo sapiens (Human) 199 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; positive regulation of apoptotic signaling pathway [GO:2001235]; regulation of apoptotic process [GO:0042981]" GO:0002020; GO:0005634; GO:0005737; GO:0005829; GO:0006919; GO:0006977; GO:0008625; GO:0030674; GO:0042981; GO:0070513; GO:0071260; GO:2001235 0 0 0 PF00619;PF00531; Q09214 CHOYP_CASP7.4.23 m.12471 sp YP65_CAEEL 52.688 93 43 1 25 117 96 187 4.26E-29 113 YP65_CAEEL reviewed Uncharacterized protein B0495.5 B0495.5 Caenorhabditis elegans 729 0 GO:0003824 0 0 cd02955; PF03190; Q10711 CHOYP_DYAK_GE13998.1.1 m.12821 sp ECE2_BOVIN 31.122 196 131 4 1 194 599 792 4.26E-26 112 ECE2_BOVIN reviewed Endothelin-converting enzyme 2 (ECE-2) [Includes: Methyltransferase-like region (EC 2.1.1.-); Endothelin-converting enzyme 2 region (EC 3.4.24.71)] ECE2 Bos taurus (Bovine) 883 brain development [GO:0007420]; cardioblast differentiation [GO:0010002]; embryo development [GO:0009790]; heart development [GO:0007507]; peptide hormone processing [GO:0016486]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; vasoconstriction [GO:0042310] GO:0000139; GO:0004222; GO:0007420; GO:0007507; GO:0008168; GO:0008277; GO:0009790; GO:0010002; GO:0016021; GO:0016486; GO:0030659; GO:0042310; GO:0042803; GO:0046872 0 0 cd08662; PF01431;PF05649; Q5RJI4 CHOYP_LOC100650469.1.2 m.42140 sp PKDCC_MOUSE 26.781 407 248 9 124 526 130 490 4.26E-33 137 PKDCC_MOUSE reviewed "Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)" Pkdcc Sgk493 Vlk Mus musculus (Mouse) 492 bone mineralization [GO:0030282]; cell differentiation [GO:0030154]; embryonic digestive tract development [GO:0048566]; limb morphogenesis [GO:0035108]; lung alveolus development [GO:0048286]; multicellular organism growth [GO:0035264]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; palate development [GO:0060021]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of chondrocyte differentiation [GO:0032332]; protein transport [GO:0015031]; skeletal system development [GO:0001501] GO:0001501; GO:0004672; GO:0004715; GO:0005524; GO:0005576; GO:0005794; GO:0015031; GO:0018108; GO:0030154; GO:0030282; GO:0030501; GO:0032332; GO:0035108; GO:0035264; GO:0042997; GO:0048286; GO:0048566; GO:0060021 0 0 0 PF12260; Q86U86 CHOYP_PB1.4.6 m.23067 sp PB1_HUMAN 42.633 509 237 12 1 475 1002 1489 4.26E-111 366 PB1_HUMAN reviewed Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 "chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0003682; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0008285; GO:0016569; GO:0090544 0 0 0 PF01426;PF00439;PF00505; Q8IV35 CHOYP_LOC579391.1.1 m.6413 sp WDR49_HUMAN 41.844 705 366 10 371 1060 7 682 4.26E-177 539 WDR49_HUMAN reviewed WD repeat-containing protein 49 WDR49 Homo sapiens (Human) 697 0 0 0 0 0 PF00400; Q8N6F8 CHOYP_BRAFLDRAFT_126943.3.3 m.30934 sp WBS27_HUMAN 35.652 115 71 3 15 129 89 200 4.26E-15 72.8 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q8NDA8 CHOYP_HEATR7A.1.1 m.6534 sp MROH1_HUMAN 35.358 642 335 9 1 567 224 860 4.26E-126 408 MROH1_HUMAN reviewed Maestro heat-like repeat-containing protein family member 1 (HEAT repeat-containing protein 7A) MROH1 HEATR7A KIAA1833 Homo sapiens (Human) 1641 0 0 0 0 0 PF02985; Q98TR7 CHOYP_RPS16.1.1 m.57700 sp RS16_HETFO 88.976 127 14 0 5 131 2 128 4.26E-79 233 RS16_HETFO reviewed 40S ribosomal protein S16 rps16 Heteropneustes fossilis (Stinging catfish) 146 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00380; Q9ULJ7 CHOYP_LOC100640442.2.10 m.20616 sp ANR50_HUMAN 30.986 639 354 26 17 630 526 1102 4.26E-48 186 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9UPW6 CHOYP_DWIL_GK20806.1.1 m.36870 sp SATB2_HUMAN 27.861 201 131 4 61 254 50 243 4.26E-19 95.9 SATB2_HUMAN reviewed DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) SATB2 KIAA1034 Homo sapiens (Human) 733 "cartilage development [GO:0051216]; cellular response to organic substance [GO:0071310]; chromatin remodeling [GO:0006338]; commitment of neuronal cell to specific neuron type in forebrain [GO:0021902]; covalent chromatin modification [GO:0016569]; embryonic pattern specification [GO:0009880]; embryonic skeletal system morphogenesis [GO:0048704]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron migration [GO:0001764]; osteoblast development [GO:0002076]; palate development [GO:0060021]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000122; GO:0001764; GO:0002076; GO:0003682; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006338; GO:0006351; GO:0006357; GO:0009880; GO:0016363; GO:0016569; GO:0021902; GO:0043565; GO:0045944; GO:0048704; GO:0051216; GO:0060021; GO:0071310 0 0 0 PF02376;PF16557;PF00046;PF16534; Q9Y305 CHOYP_LOC100691486.1.1 m.24964 sp ACOT9_HUMAN 47.315 391 199 6 49 435 37 424 4.26E-113 342 ACOT9_HUMAN reviewed "Acyl-coenzyme A thioesterase 9, mitochondrial (Acyl-CoA thioesterase 9) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 9)" ACOT9 CGI-16 Homo sapiens (Human) 439 acyl-CoA metabolic process [GO:0006637]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338] GO:0003986; GO:0005739; GO:0005759; GO:0006637; GO:0035338; GO:0047617; GO:0052689 0 0 0 0 A1A600 CHOYP_LOC100377113.2.3 m.19126 sp EFC4A_DANRE 39.222 334 194 2 11 344 27 351 4.27E-67 227 EFC4A_DANRE reviewed EF-hand calcium-binding domain-containing protein 4A (Calcium release-activated channel regulator 2B) cracr2b efcab4a zgc:158448 Danio rerio (Zebrafish) (Brachydanio rerio) 390 0 GO:0005509 0 0 0 PF13499; A2XYY8 CHOYP_ANM12.1.1 m.53881 sp ANM61_ORYSI 32.331 133 80 2 68 190 244 376 4.27E-13 72 ANM61_ORYSI reviewed Probable protein arginine N-methyltransferase 6.1 (EC 2.1.1.-) PRMT6.1 H0402C08.4 OsI_017281 Oryza sativa subsp. indica (Rice) 379 protein methylation [GO:0006479] GO:0006479; GO:0008168 0 0 0 0 B2GUV7 CHOYP_contig_025641 m.29256 sp IF2P_RAT 41.6 125 61 3 173 292 400 517 4.27E-10 66.2 IF2P_RAT reviewed Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Annexin V-binding protein ABP-7) (Translation initiation factor IF-2) Eif5b If2 Rattus norvegicus (Rat) 1216 translation [GO:0006412] GO:0003743; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412; GO:0046872 0 0 0 PF03144;PF11987; O60884 CHOYP_LOC577887.1.1 m.49105 sp DNJA2_HUMAN 63.423 298 105 3 18 312 116 412 4.27E-131 382 DNJA2_HUMAN reviewed DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) DNAJA2 CPR3 HIRIP4 Homo sapiens (Human) 412 carbon tetrachloride metabolic process [GO:0018885]; positive regulation of cell proliferation [GO:0008284]; protein refolding [GO:0042026]; response to heat [GO:0009408] GO:0001948; GO:0005524; GO:0005634; GO:0005829; GO:0008284; GO:0009408; GO:0016020; GO:0018885; GO:0042026; GO:0046872; GO:0051082; GO:0051087; GO:0070062 0 0 cd06257; PF00226;PF01556;PF00684; O95236 CHOYP_contig_045813 m.53435 sp APOL3_HUMAN 24.454 229 148 6 842 1052 161 382 4.27E-06 53.9 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P04323 CHOYP_LOC100142324.1.1 m.9182 sp POL3_DROME 40.541 259 142 4 1 255 378 628 4.27E-55 205 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P10079 CHOYP_NOTC2.3.5 m.54439 sp FBP1_STRPU 44.662 459 254 0 494 952 483 941 4.27E-116 397 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P14133 CHOYP_DVIR_GJ17860.1.1 m.13357 sp ASO_CUCSA 35.814 215 90 9 46 248 32 210 4.27E-30 127 ASO_CUCSA reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) 0 Cucumis sativus (Cucumber) 587 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P49013 CHOYP_LOC100634060.30.37 m.64572 sp FBP3_STRPU 55.263 152 68 0 358 509 176 327 4.27E-47 178 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P62257 CHOYP_UBE2H.1.1 m.49863 sp UBE2H_MOUSE 85.106 141 21 0 23 163 19 159 4.27E-92 269 UBE2H_MOUSE reviewed Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UBCH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) Ube2h Mus musculus (Mouse) 183 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936] GO:0004842; GO:0005524; GO:0005737; GO:0031625; GO:0043161; GO:0061630; GO:0061631; GO:0070936; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; P98158 CHOYP_LRP2.7.7 m.45284 sp LRP2_RAT 48.515 101 52 0 1 101 3736 3836 4.27E-25 107 LRP2_RAT reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) 4660 aging [GO:0007568]; endosomal transport [GO:0016197]; hemoglobin import [GO:0020028]; hormone secretion [GO:0046879]; lipoprotein transport [GO:0042953]; negative regulation of endopeptidase activity [GO:0010951]; organ regeneration [GO:0031100]; receptor-mediated endocytosis [GO:0006898]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; transcytosis [GO:0045056]; vitamin metabolic process [GO:0006766] GO:0004872; GO:0005509; GO:0005615; GO:0005737; GO:0005768; GO:0005903; GO:0005905; GO:0006766; GO:0006898; GO:0007568; GO:0010165; GO:0010951; GO:0016020; GO:0016021; GO:0016197; GO:0016324; GO:0020028; GO:0030165; GO:0030492; GO:0031100; GO:0031526; GO:0032403; GO:0032526; GO:0033280; GO:0042493; GO:0042562; GO:0042953; GO:0043234; GO:0045056; GO:0045121; GO:0046879; GO:0050750 0 0 0 PF12662;PF07645;PF00057;PF00058; Q16820 CHOYP_LOC100372616.2.3 m.5692 sp MEP1B_HUMAN 28.829 444 239 15 46 466 48 437 4.27E-44 167 MEP1B_HUMAN reviewed Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta) MEP1B Homo sapiens (Human) 701 digestion [GO:0007586]; inflammatory response [GO:0006954]; toxin transport [GO:1901998] GO:0004222; GO:0005615; GO:0005886; GO:0005887; GO:0006954; GO:0007586; GO:0008270; GO:1901998 0 0 cd06263; PF01400;PF00629; Q5FVR8 CHOYP_LOC100370965.1.1 m.13129 sp TBCC1_RAT 44.956 565 292 9 11 570 8 558 4.27E-174 507 TBCC1_RAT reviewed TBCC domain-containing protein 1 Tbccd1 Rattus norvegicus (Rat) 569 cell morphogenesis [GO:0000902]; maintenance of centrosome location [GO:0051661]; maintenance of Golgi location [GO:0051684]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360] GO:0000902; GO:0005737; GO:0008360; GO:0030334; GO:0031616; GO:0051661; GO:0051684 0 0 0 PF07986; Q5RHP9 CHOYP_LOC100179357.1.6 m.15104 sp ERIC3_HUMAN 37.5 424 199 12 1 385 1 397 4.27E-69 260 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q5XHB2 CHOYP_DANA_GF10970.1.1 m.53493 sp DUS22_XENTR 54.706 170 77 0 1 170 1 170 4.27E-66 209 DUS22_XENTR reviewed Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) dusp22 TEgg009e03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 209 positive regulation of JNK cascade [GO:0046330]; regulation of cell proliferation [GO:0042127]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0004725; GO:0005634; GO:0005737; GO:0007179; GO:0008138; GO:0042127; GO:0046330 0 0 0 PF00782; Q6GPA8 CHOYP_SCAM5.1.1 m.15801 sp SCM5A_XENLA 39.815 108 56 2 2 108 119 218 4.27E-17 76.6 SCM5A_XENLA reviewed Secretory carrier-associated membrane protein 5A (Secretory carrier membrane protein 5 A) scamp5-a Xenopus laevis (African clawed frog) 235 exocytosis [GO:0006887]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of cytokine secretion [GO:0050715]; protein transport [GO:0015031] GO:0000139; GO:0005886; GO:0006887; GO:0015031; GO:0016021; GO:0030054; GO:0030672; GO:0045956; GO:0050715; GO:0055038 0 0 0 PF04144; Q6NS45 CHOYP_BRAFLDRAFT_121183.2.8 m.17288 sp CCD66_MOUSE 36.735 147 92 1 616 762 438 583 4.27E-12 74.7 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q8ISN9 CHOYP_RS25.1.11 m.1834 sp RS25_BRABE 69.565 115 33 1 21 135 3 115 4.27E-36 123 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8UVC3 CHOYP_LOC752844.4.4 m.36712 sp INVS_CHICK 23.785 391 212 13 360 718 179 515 4.27E-13 77 INVS_CHICK reviewed Inversin INVS Gallus gallus (Chicken) 1106 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005737; GO:0005856; GO:0007275; GO:0016055 0 0 0 PF12796;PF00612; Q91WU4 CHOYP_TMCO4.1.1 m.378 sp TMCO4_MOUSE 48.881 581 286 6 4 576 25 602 4.27E-161 481 TMCO4_MOUSE reviewed Transmembrane and coiled-coil domain-containing protein 4 Tmco4 Mus musculus (Mouse) 631 0 GO:0016021 0 0 0 PF05277; Q96RW7 CHOYP_LOC100332237.1.1 m.18128 sp HMCN1_HUMAN 41.346 104 56 2 97 195 4538 4641 4.27E-19 89 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9CXP9 CHOYP_EXO5.1.1 m.49484 sp EXO5_MOUSE 42.051 195 108 3 1 193 164 355 4.27E-48 164 EXO5_MOUSE reviewed Exonuclease V (Exo V) (mExo5) (EC 3.1.-.-) (Defects in morphology protein 1 homolog) Exo5 Dem1 Mus musculus (Mouse) 373 interstrand cross-link repair [GO:0036297] GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0036297; GO:0045145; GO:0046872; GO:0051539 0 0 0 PF09810; Q9EQ32 CHOYP_BCAP.1.2 m.20149 sp BCAP_MOUSE 29.714 175 113 3 199 367 222 392 4.27E-14 78.6 BCAP_MOUSE reviewed Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) Pik3ap1 Bcap Mus musculus (Mouse) 811 negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] GO:0005737; GO:0005829; GO:0005886; GO:0014068; GO:0016020; GO:0034122; GO:0034123; GO:0034134; GO:0034142; GO:0034154; GO:0034162; GO:0036312; GO:0042802; GO:0050727 0 0 0 PF14545; Q9VFK6 CHOYP_LOC100890715.1.1 m.47961 sp KMT5A_DROME 30.894 123 78 4 49 166 555 675 4.27E-12 66.6 KMT5A_DROME reviewed Histone-lysine N-methyltransferase pr-set7 (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (dSET8) pr-set7 KMT5A CG3307 Drosophila melanogaster (Fruit fly) 691 "cell division [GO:0051301]; chromosome condensation [GO:0030261]; DNA damage checkpoint [GO:0000077]; histone H4-K20 monomethylation [GO:0034771]; histone methylation [GO:0016571]; mitotic nuclear division [GO:0007067]; negative regulation of histone acetylation [GO:0035067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000077; GO:0005634; GO:0005700; GO:0006351; GO:0006355; GO:0007067; GO:0016571; GO:0030261; GO:0034771; GO:0035067; GO:0042799; GO:0051301 0 0 0 PF00856; A0JNI4 CHOYP_DAR1.4.4 m.62070 sp SRR_BOVIN 51 100 47 2 17 116 230 327 4.28E-24 97.1 SRR_BOVIN reviewed Serine racemase (EC 4.3.1.17) (EC 4.3.1.18) (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (L-serine ammonia-lyase) (L-serine dehydratase) SRR Bos taurus (Bovine) 334 brain development [GO:0007420]; D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496] GO:0000287; GO:0003941; GO:0005509; GO:0005524; GO:0005737; GO:0006563; GO:0007420; GO:0008721; GO:0016594; GO:0018114; GO:0030170; GO:0030378; GO:0032496; GO:0042866; GO:0043025; GO:0051289; GO:0070178; GO:0070179 0 0 0 PF00291; A8MVX0 CHOYP_ARHGEF33.1.1 m.66446 sp ARG33_HUMAN 23.79 496 299 15 112 545 22 500 4.28E-21 103 ARG33_HUMAN reviewed Rho guanine nucleotide exchange factor 33 ARHGEF33 Homo sapiens (Human) 844 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF00621; B3EWZ6 CHOYP_BRAFLDRAFT_227771.1.2 m.60606 sp MLRP2_ACRMI 28.65 911 468 30 607 1419 729 1555 4.28E-74 278 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O60462 CHOYP_BRAFLDRAFT_143777.1.2 m.24089 sp NRP2_HUMAN 29.075 227 142 4 27 236 40 264 4.28E-20 98.6 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O75956 CHOYP_BRAFLDRAFT_230475.2.3 m.39193 sp CDKA2_HUMAN 45.763 118 53 3 50 167 20 126 4.28E-26 99 CDKA2_HUMAN reviewed Cyclin-dependent kinase 2-associated protein 2 (CDK2-associated protein 2) (DOC-1-related protein) (DOC-1R) CDK2AP2 DOC1R Homo sapiens (Human) 126 0 0 0 0 0 PF09806; P06916 CHOYP_contig_010660 m.12348 sp FIRA_PLAFF 53.947 76 35 0 28 103 29 104 4.28E-12 63.5 FIRA_PLAFF reviewed 300 kDa antigen AG231 (Fragment) FIRA Plasmodium falciparum (isolate FC27 / Papua New Guinea) 310 0 0 0 0 0 PF07016; P48555 CHOYP_RALA.1.4 m.8443 sp RALA_DROME 78.218 202 42 2 1 201 1 201 4.28E-112 321 RALA_DROME reviewed Ras-related protein Ral-a Rala CG2849 Drosophila melanogaster (Fruit fly) 201 border follicle cell migration [GO:0007298]; defense response to Gram-negative bacterium [GO:0050829]; dorsal closure [GO:0007391]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of JNK cascade [GO:0046329]; R3/R4 cell fate commitment [GO:0007464]; Ras protein signal transduction [GO:0007265]; regulation of cell morphogenesis [GO:0022604]; regulation of Notch signaling pathway [GO:0008593] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007265; GO:0007298; GO:0007391; GO:0007464; GO:0008593; GO:0022604; GO:0030165; GO:0045087; GO:0045824; GO:0046329; GO:0050829 0 0 0 PF00071; P48555 CHOYP_RALA.2.4 m.11673 sp RALA_DROME 78.218 202 42 2 1 201 1 201 4.28E-112 321 RALA_DROME reviewed Ras-related protein Ral-a Rala CG2849 Drosophila melanogaster (Fruit fly) 201 border follicle cell migration [GO:0007298]; defense response to Gram-negative bacterium [GO:0050829]; dorsal closure [GO:0007391]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of JNK cascade [GO:0046329]; R3/R4 cell fate commitment [GO:0007464]; Ras protein signal transduction [GO:0007265]; regulation of cell morphogenesis [GO:0022604]; regulation of Notch signaling pathway [GO:0008593] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007265; GO:0007298; GO:0007391; GO:0007464; GO:0008593; GO:0022604; GO:0030165; GO:0045087; GO:0045824; GO:0046329; GO:0050829 0 0 0 PF00071; P48555 CHOYP_RALA.4.4 m.26413 sp RALA_DROME 78.218 202 42 2 1 201 1 201 4.28E-112 321 RALA_DROME reviewed Ras-related protein Ral-a Rala CG2849 Drosophila melanogaster (Fruit fly) 201 border follicle cell migration [GO:0007298]; defense response to Gram-negative bacterium [GO:0050829]; dorsal closure [GO:0007391]; innate immune response [GO:0045087]; negative regulation of innate immune response [GO:0045824]; negative regulation of JNK cascade [GO:0046329]; R3/R4 cell fate commitment [GO:0007464]; Ras protein signal transduction [GO:0007265]; regulation of cell morphogenesis [GO:0022604]; regulation of Notch signaling pathway [GO:0008593] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007265; GO:0007298; GO:0007391; GO:0007464; GO:0008593; GO:0022604; GO:0030165; GO:0045087; GO:0045824; GO:0046329; GO:0050829 0 0 0 PF00071; P51156 CHOYP_RAB37.1.1 m.56439 sp RAB26_RAT 68.372 215 66 1 12 224 41 255 4.28E-111 322 RAB26_RAT reviewed Ras-related protein Rab-26 Rab26 Rattus norvegicus (Rat) 257 exocrine system development [GO:0035272]; Golgi to plasma membrane protein transport [GO:0043001]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0003924; GO:0005525; GO:0007264; GO:0016192; GO:0017157; GO:0019002; GO:0030658; GO:0030667; GO:0031226; GO:0035272; GO:0043001; GO:0045055 0 0 0 PF00071; Q3KPW1 CHOYP_LOC100889152.1.1 m.10696 sp RNP1B_XENLA 67.123 73 24 0 1 73 155 227 4.28E-29 109 RNP1B_XENLA reviewed RNA-binding protein with serine-rich domain 1-B rnps1-b Xenopus laevis (African clawed frog) 283 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005737; GO:0006397; GO:0008380; GO:0016607 0 0 0 PF00076; Q68EI3 CHOYP_CBPC5.1.1 m.44628 sp CBPC5_DANRE 44.828 203 90 4 1 203 504 684 4.28E-33 137 CBPC5_DANRE reviewed Cytosolic carboxypeptidase-like protein 5 (EC 3.4.17.-) (ATP/GTP-binding protein-like 5) agbl5 ccp5 zgc:91997 Danio rerio (Zebrafish) (Brachydanio rerio) 885 chordate embryonic development [GO:0043009]; cilium morphogenesis [GO:0060271]; defense response to virus [GO:0051607]; protein branching point deglutamylation [GO:0035611]; protein deglutamylation [GO:0035608] GO:0004181; GO:0005634; GO:0005829; GO:0008270; GO:0015631; GO:0030496; GO:0035608; GO:0035611; GO:0043009; GO:0051607; GO:0060271; GO:0072686 0 0 0 PF00246; Q69ZM6 CHOYP_LOC100372921.2.2 m.56247 sp STK36_MOUSE 30.423 756 466 16 3 742 600 1311 4.28E-92 317 STK36_MOUSE reviewed Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog) Stk36 Kiaa1278 Mus musculus (Mouse) 1316 brain development [GO:0007420]; cilium assembly [GO:0042384]; epithelial cilium movement [GO:0003351]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090] GO:0003351; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0007228; GO:0007420; GO:0008134; GO:0009791; GO:0042384; GO:0045880; GO:0046872; GO:0051090 0 0 0 PF00069; Q7ZXX1 CHOYP_CADM3.4.4 m.45272 sp CADM3_XENLA 25.073 343 200 14 9 338 5 303 4.28E-11 68.6 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q96KG7 CHOYP_LOC100371242.4.6 m.46469 sp MEG10_HUMAN 39.785 279 148 14 164 441 355 614 4.28E-38 151 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q9BXR5 CHOYP_BRAFLDRAFT_87577.1.2 m.19388 sp TLR10_HUMAN 32.143 112 63 4 145 252 606 708 4.28E-08 58.5 TLR10_HUMAN reviewed Toll-like receptor 10 (CD antigen CD290) TLR10 UNQ315/PRO358 Homo sapiens (Human) 811 immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of inflammatory response [GO:0050729]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0002755; GO:0004888; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0016020; GO:0034166; GO:0045087; GO:0050707; GO:0050729 0 0 0 PF00560;PF13855;PF01582; Q9ESN6 CHOYP_TRIM3.56.58 m.64482 sp TRIM2_MOUSE 30.047 213 121 10 151 350 536 733 4.28E-12 70.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9LIG0 CHOYP_SELMODRAFT_90998.1.1 m.49220 sp Y3136_ARATH 49.08 326 164 2 12 337 7 330 4.28E-113 334 Y3136_ARATH reviewed Clavaminate synthase-like protein At3g21360 (EC 1.-.-.-) At3g21360 MHC9_4 Arabidopsis thaliana (Mouse-ear cress) 330 0 GO:0005634; GO:0016491; GO:0046872 0 0 0 PF02668; Q9U489 CHOYP_BRAFLDRAFT_118791.1.1 m.35120 sp LIN41_CAEEL 32.673 101 62 3 285 380 851 950 4.28E-07 55.8 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9UBI9 CHOYP_LOC100644701.2.2 m.54959 sp HDC_HUMAN 35.021 474 262 8 43 496 94 541 4.28E-90 288 HDC_HUMAN reviewed Headcase protein homolog (hHDC) HECA HDC Homo sapiens (Human) 543 negative regulation of mitotic cell cycle [GO:0045930]; respiratory tube development [GO:0030323] GO:0005634; GO:0005737; GO:0016020; GO:0030323; GO:0045930 0 0 0 PF16002;PF15353; Q9V5L3 CHOYP_LOC100374454.1.1 m.1322 sp C49A1_DROME 39.333 150 84 1 1 143 438 587 4.28E-32 122 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; C9JN71 CHOYP_ZN345.1.1 m.26815 sp ZN878_HUMAN 42.487 193 108 1 18 210 336 525 4.29E-45 167 ZN878_HUMAN reviewed Zinc finger protein 878 ZNF878 Homo sapiens (Human) 531 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; F6S215 CHOYP_NEMVEDRAFT_V1G238136.1.1 m.49104 sp AP5B1_XENTR 22.011 895 588 22 33 869 32 874 4.29E-47 184 AP5B1_XENTR reviewed AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) ap5b1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 883 endosomal transport [GO:0016197]; protein transport [GO:0015031] GO:0005765; GO:0015031; GO:0016197; GO:0030119 0 0 0 0 G3V893 CHOYP_ZN169.2.2 m.18739 sp ZN335_RAT 47.917 48 25 0 117 164 1076 1123 4.29E-10 60.8 ZN335_RAT reviewed Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1) Znf335 Zfp335 Rattus norvegicus (Rat) 1336 "brain development [GO:0007420]; histone H3-K4 trimethylation [GO:0080182]; neuron projection morphogenesis [GO:0048812]; positive regulation of ligand-dependent nuclear receptor transcription coactivator activity [GO:2000327]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of gene expression, epigenetic [GO:0040029]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0002052; GO:0005634; GO:0006351; GO:0006355; GO:0007420; GO:0040029; GO:0044212; GO:0046872; GO:0048812; GO:0050671; GO:0080182; GO:2000327 0 0 0 PF13912; G3V8T1 CHOYP_MPP8.1.1 m.66847 sp MPP8_RAT 37.624 101 56 1 1 101 23 116 4.29E-12 66.6 MPP8_RAT reviewed M-phase phosphoprotein 8 Mphosph8 Mpp8 Rattus norvegicus (Rat) 851 "negative regulation of transcription, DNA-templated [GO:0045892]; regulation of DNA methylation [GO:0044030]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000788; GO:0004842; GO:0005634; GO:0005720; GO:0005737; GO:0006351; GO:0031625; GO:0035064; GO:0044030; GO:0045892 0 0 0 PF12796;PF00385; O00370 CHOYP_LOC100562878.2.2 m.66123 sp LORF2_HUMAN 30.867 392 266 3 2 388 425 816 4.29E-47 176 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; P06605 CHOYP_AAEL_AAEL013229.1.2 m.30359 sp TBA3_DROME 71.739 184 39 2 1 173 36 217 4.29E-82 254 TBA3_DROME reviewed Tubulin alpha-3 chain alphaTub84D TubA84D CG2512 Drosophila melanogaster (Fruit fly) 450 microtubule-based process [GO:0007017]; mitotic cytokinesis [GO:0000281] GO:0000281; GO:0003924; GO:0005200; GO:0005525; GO:0005811; GO:0005874; GO:0007017; GO:0017022; GO:0048471 0 0 0 PF00091;PF03953; P32138 CHOYP_LOC100369482.2.2 m.12628 sp SQASE_ECOLI 41.06 151 73 1 1 151 131 265 4.29E-36 137 SQASE_ECOLI reviewed Sulfoquinovosidase (SQase) (EC 3.2.1.-) yihQ squQ b3878 JW3849 Escherichia coli (strain K12) 678 carbohydrate metabolic process [GO:0005975] GO:0004553; GO:0005975; GO:0030246 PATHWAY: Glycolipid metabolism. {ECO:0000305|PubMed:24463506}. 0 0 PF01055; Q06806 CHOYP_LOC575944.1.5 m.22548 sp TIE1_MOUSE 36.111 108 59 5 33 136 236 337 4.29E-13 68.2 TIE1_MOUSE reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) 1134 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; response to retinoic acid [GO:0032526]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001701; GO:0004714; GO:0005524; GO:0005886; GO:0016021; GO:0016525; GO:0030336; GO:0032526; GO:0045026 0 0 0 PF00041;PF00047;PF07714; Q09575 CHOYP_LOC100374695.1.1 m.49920 sp YRD6_CAEEL 27.845 413 276 9 65 470 747 1144 4.29E-42 164 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q4V886 CHOYP_CPIPJ_CPIJ007723.4.4 m.64973 sp PAF1_RAT 57.054 482 169 7 22 492 1 455 4.29E-173 501 PAF1_RAT reviewed RNA polymerase II-associated factor 1 homolog Paf1 Rattus norvegicus (Rat) 535 cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; histone H2B ubiquitination [GO:0033523]; histone monoubiquitination [GO:0010390]; mRNA polyadenylation [GO:0006378]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome positioning [GO:0016584]; positive regulation of histone methylation [GO:0031062]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell population maintenance [GO:0019827]; transcription elongation from RNA polymerase II promoter [GO:0006368]; Wnt signaling pathway [GO:0016055] GO:0000122; GO:0000993; GO:0001711; GO:0003682; GO:0005737; GO:0006368; GO:0006378; GO:0010390; GO:0016020; GO:0016055; GO:0016584; GO:0016593; GO:0019827; GO:0030054; GO:0031062; GO:0031442; GO:0032968; GO:0033523; GO:0034504; GO:0045638; GO:0045944; GO:0071222 0 0 0 PF03985; Q5T0B9 CHOYP_ZN384.1.1 m.44090 sp ZN362_HUMAN 40.881 159 68 4 109 242 242 399 4.29E-30 124 ZN362_HUMAN reviewed Zinc finger protein 362 ZNF362 PP6997 Homo sapiens (Human) 420 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q5TYQ8 CHOYP_LOC101155562.1.1 m.51414 sp ZC3HE_DANRE 46.121 232 88 10 582 796 455 666 4.29E-55 205 ZC3HE_DANRE reviewed Zinc finger CCCH domain-containing protein 14 zc3h14 si:dkey-199i12.4 zgc:136266 Danio rerio (Zebrafish) (Brachydanio rerio) 669 negative regulation of mRNA polyadenylation [GO:1900364]; regulation of mRNA stability [GO:0043488] GO:0005634; GO:0005737; GO:0008143; GO:0016607; GO:0043488; GO:0044822; GO:0046872; GO:1900364 0 0 0 0 Q80V70 CHOYP_LOC763793.1.7 m.13857 sp MEGF6_MOUSE 30.739 514 304 18 166 652 733 1221 4.29E-37 152 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8BNU0 CHOYP_ARMC6.1.1 m.28786 sp ARMC6_MOUSE 43.897 467 259 3 2 466 3 468 4.29E-126 377 ARMC6_MOUSE reviewed Armadillo repeat-containing protein 6 Armc6 Mus musculus (Mouse) 468 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244 0 0 0 PF00514; Q8R0M8 CHOYP_MOT5.2.2 m.46407 sp MOT5_MOUSE 27.203 522 336 10 9 527 13 493 4.29E-47 174 MOT5_MOUSE reviewed Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) 500 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; Q96HV5 CHOYP_LOC100181666.1.1 m.1716 sp TM41A_HUMAN 54.839 248 108 2 1 244 1 248 4.29E-85 257 TM41A_HUMAN reviewed Transmembrane protein 41A TMEM41A UNQ168/PRO194 Homo sapiens (Human) 264 0 GO:0016021 0 0 0 PF09335; Q9I9M5 CHOYP_FZD1.2.2 m.50427 sp FZD1_XENLA 58.108 148 55 3 22 162 38 185 4.29E-53 184 FZD1_XENLA reviewed Frizzled-1 (Fz-1) (Xfz1) fzd1 fz1 Xenopus laevis (African clawed frog) 559 multicellular organism development [GO:0007275] GO:0004930; GO:0005886; GO:0007275; GO:0016021; GO:0042813 0 0 0 PF01534;PF01392; Q9JIB0 CHOYP_RANGRF.1.2 m.18930 sp MOG1_MOUSE 39.13 161 93 3 17 176 27 183 4.29E-33 119 MOG1_MOUSE reviewed Ran guanine nucleotide release factor (RanGNRF) (Ran-binding protein MOG1) Rangrf Mog1 Rangnrf Mus musculus (Mouse) 185 ER to Golgi vesicle-mediated transport [GO:0006888]; nucleocytoplasmic transport [GO:0006913]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of protein localization to cell surface [GO:2000010]; protein exit from endoplasmic reticulum [GO:0032527]; regulation of membrane depolarization [GO:0003254]; regulation of membrane potential [GO:0042391]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of sodium ion transmembrane transporter activity [GO:2000649] GO:0003254; GO:0005085; GO:0005087; GO:0005634; GO:0005654; GO:0005737; GO:0005791; GO:0005901; GO:0006888; GO:0006913; GO:0008536; GO:0008565; GO:0014704; GO:0017080; GO:0032527; GO:0042391; GO:0044325; GO:0090004; GO:1902305; GO:2000010; GO:2000649 0 0 0 PF04603; Q9NFP5 CHOYP_LOC100863791.1.2 m.43090 sp SH3BG_DROME 43.59 117 56 3 1 108 1 116 4.29E-24 100 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G241256.1.1 m.44883 sp SACS_HUMAN 33.333 111 58 3 13 122 4317 4412 4.29E-11 62.8 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9UPS8 CHOYP_ANKRD7.3.3 m.33166 sp ANR26_HUMAN 27.507 1047 636 26 1155 2131 716 1709 4.29E-68 259 ANR26_HUMAN reviewed Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) 1709 0 GO:0005813 0 0 0 PF00023;PF12796;PF12001; Q9V4M2 CHOYP_BRAFLDRAFT_88217.1.14 m.660 sp WECH_DROME 25.781 128 76 6 3 113 111 236 4.29E-06 47.4 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; Q9Y535 CHOYP_BRAFLDRAFT_104488.3.3 m.2973 sp RPC8_HUMAN 67.647 204 65 1 1 204 1 203 4.29E-103 298 RPC8_HUMAN reviewed DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9) POLR3H KIAA1665 RPC8 Homo sapiens (Human) 204 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of type I interferon production [GO:0032481]; transcription from RNA polymerase III promoter [GO:0006383]; transcription initiation from RNA polymerase III promoter [GO:0006384] GO:0003677; GO:0003899; GO:0005654; GO:0005666; GO:0005813; GO:0005829; GO:0006139; GO:0006383; GO:0006384; GO:0032481; GO:0043231; GO:0045087; GO:0051607 0 0 0 PF08292;PF03876; A4IF63 CHOYP_TRI55.2.2 m.48422 sp TRIM2_BOVIN 25.197 254 142 6 1 237 1 223 4.30E-14 78.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_TRIM2.34.59 m.38011 sp TRIM2_BOVIN 28.216 241 144 9 123 351 506 729 4.30E-13 73.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B3EWZ6 CHOYP_LOC100372616.1.3 m.4655 sp MLRP2_ACRMI 38.889 504 273 18 352 838 201 686 4.30E-90 317 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E7FCN8 CHOYP_INTU.1.3 m.8678 sp INTU_DANRE 26.452 930 552 25 9 835 13 913 4.30E-80 280 INTU_DANRE reviewed Protein inturned (Inturned planar cell polarity effector homolog) intu Danio rerio (Zebrafish) (Brachydanio rerio) 915 cilium assembly [GO:0042384]; limb development [GO:0060173]; nervous system development [GO:0007399]; regulation of smoothened signaling pathway [GO:0008589] GO:0005737; GO:0007399; GO:0008589; GO:0009986; GO:0042384; GO:0060173 0 0 0 0 O15040 CHOYP_BRAFLDRAFT_216841.3.4 m.55406 sp TCPR2_HUMAN 33.173 624 379 15 933 1528 798 1411 4.30E-97 347 TCPR2_HUMAN reviewed Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) 1411 autophagy [GO:0006914] GO:0006914 0 0 0 PF06462; P17126 CHOYP_ACT.9.27 m.24630 sp ACT_HYDVU 99.441 179 1 0 1 179 20 198 4.30E-131 376 ACT_HYDVU reviewed "Actin, non-muscle 6.2" 0 Hydra vulgaris (Hydra) (Hydra attenuata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P25291 CHOYP_BRAFLDRAFT_88358.1.1 m.52404 sp GP2_CANLF 34.426 122 67 4 17 126 32 152 4.30E-12 67.8 GP2_CANLF reviewed Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis lupus familiaris (Dog) (Canis familiaris) 509 0 GO:0005576; GO:0005886; GO:0031225 0 0 0 PF00100; Q02357 CHOYP_AFUA_1G01020.1.50 m.469 sp ANK1_MOUSE 40.385 208 124 0 5 212 184 391 4.30E-35 134 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q17QJ7 CHOYP_ISCW_ISCW020302.1.1 m.37564 sp P5CR2_BOVIN 52.222 270 120 3 15 277 1 268 4.30E-90 275 P5CR2_BOVIN reviewed Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) PYCR2 Bos taurus (Bovine) 320 cellular response to oxidative stress [GO:0034599]; L-proline biosynthetic process [GO:0055129]; proline biosynthetic process [GO:0006561] GO:0004735; GO:0005739; GO:0006561; GO:0034599; GO:0055129 PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. 0 0 PF03807;PF14748; Q24372 CHOYP_SMP_174040.1.3 m.20260 sp LACH_DROME 30.455 220 121 11 2 215 9 202 4.30E-13 70.5 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q4QQM4 CHOYP_P5I11.1.1 m.63338 sp P5I11_MOUSE 41.243 177 102 2 8 182 11 187 4.30E-40 137 P5I11_MOUSE reviewed Tumor protein p53-inducible protein 11 (Transformation related protein 53 inducible protein 11) (p53-induced gene 11 protein) Trp53i11 Pig11 Tp53i11 Mus musculus (Mouse) 189 0 GO:0016021 0 0 0 PF14936; Q5ND28 CHOYP_PHUM_PHUM049590.2.4 m.40010 sp SREC_MOUSE 31.164 292 140 15 204 489 153 389 4.30E-16 85.9 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q68VK5 CHOYP_LOC100646683.1.1 m.23455 sp TSN5_RAT 46.715 137 69 3 1 136 20 153 4.30E-27 104 TSN5_RAT reviewed Tetraspanin-5 (Tspan-5) (Transmembrane 4 superfamily member 9) Tspan5 Tm4sf9 Rattus norvegicus (Rat) 268 cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007155; GO:0007166; GO:0008283; GO:0016021; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q6AXS0 CHOYP_NCKX6.1.1 m.52502 sp NCKX6_RAT 44.804 587 285 10 31 602 18 580 4.30E-160 474 NCKX6_RAT reviewed "Sodium/potassium/calcium exchanger 6, mitochondrial (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)" Slc8b1 Nckx6 Nclx Slc24a6 Rattus norvegicus (Rat) 585 glucose homeostasis [GO:0042593]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of insulin secretion [GO:0050796]; response to stimulus [GO:0050896] GO:0005432; GO:0005739; GO:0005743; GO:0005829; GO:0006851; GO:0030061; GO:0032592; GO:0042383; GO:0042593; GO:0042802; GO:0042803; GO:0050796; GO:0050896; GO:0051480; GO:0051560 0 0 0 PF01699; Q7KNF2 CHOYP_PABP2.1.1 m.12768 sp PABP2_DROME 58.716 218 73 7 23 225 9 224 4.30E-75 229 PABP2_DROME reviewed Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (dPABP2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Protein rox2) Pabp2 rox2 CG2163 Drosophila melanogaster (Fruit fly) 224 "mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; neurogenesis [GO:0022008]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]" GO:0000166; GO:0000289; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005737; GO:0006378; GO:0008143; GO:0022008; GO:0071011; GO:0071013 0 0 0 PF00076; Q8CE96 CHOYP_TRMT6.1.1 m.8062 sp TRM6_MOUSE 41.589 428 237 4 20 436 21 446 4.30E-110 337 TRM6_MOUSE reviewed tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) Trmt6 Kiaa1153 Trm6 Mus musculus (Mouse) 497 tRNA methylation [GO:0030488] GO:0005634; GO:0030488; GO:0031515; GO:0044822 0 0 0 PF04189; Q8VCT4 CHOYP_LOC100927475.1.1 m.28390 sp CES1D_MOUSE 32.616 558 314 20 6 535 2 525 4.30E-75 252 CES1D_MOUSE reviewed Carboxylesterase 1D (Carboxylesterase 3) (EC 3.1.1.1) (EC 3.1.1.67) (Fatty acid ethyl ester synthase) (FAEE synthase) (Triacylglycerol hydrolase) (TGH) Ces1d Ces1 Ces3 Mus musculus (Mouse) 565 acyl-CoA metabolic process [GO:0006637]; acylglycerol catabolic process [GO:0046464]; epithelial cell differentiation [GO:0030855]; lipid catabolic process [GO:0016042]; response to toxic substance [GO:0009636]; short-chain fatty acid catabolic process [GO:0019626]; very-low-density lipoprotein particle assembly [GO:0034379] GO:0004771; GO:0004806; GO:0005615; GO:0005783; GO:0005788; GO:0005811; GO:0005829; GO:0006637; GO:0009636; GO:0016042; GO:0019626; GO:0030339; GO:0030855; GO:0034379; GO:0046464; GO:0052689 0 0 0 PF00135; Q8VIK5 CHOYP_LOC100907349.3.3 m.52972 sp PEAR1_MOUSE 38.667 225 123 9 186 409 482 692 4.30E-32 132 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q92752 CHOYP_FIBB.2.3 m.46936 sp TENR_HUMAN 42.213 244 129 8 81 320 1107 1342 4.30E-52 187 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q96II8 CHOYP_LRCH3.4.4 m.63278 sp LRCH3_HUMAN 54.661 236 106 1 12 247 44 278 4.30E-75 258 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q96LT7 CHOYP_LOC594434.1.1 m.43654 sp CI072_HUMAN 31.818 286 177 4 6 274 182 466 4.30E-40 148 CI072_HUMAN reviewed Protein C9orf72 C9orf72 Homo sapiens (Human) 481 autophagy [GO:0006914]; endocytosis [GO:0006897] GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0005768; GO:0005776; GO:0006897; GO:0006914; GO:0015629; GO:0017137; GO:0031410; GO:0045171 0 0 0 PF15019; Q99020 CHOYP_ROAA.1.6 m.19696 sp ROAA_MOUSE 55.422 166 73 1 85 250 70 234 4.30E-56 187 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q99PF4 CHOYP_CDH23.1.2 m.23300 sp CAD23_MOUSE 35.762 151 87 6 16 160 2063 2209 4.30E-13 69.3 CAD23_MOUSE reviewed Cadherin-23 (Otocadherin) Cdh23 Mus musculus (Mouse) 3354 auditory receptor cell differentiation [GO:0042491]; auditory receptor cell stereocilium organization [GO:0060088]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; cell adhesion [GO:0007155]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; inner ear morphogenesis [GO:0042472]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; post-embryonic organ morphogenesis [GO:0048563]; regulation of cytosolic calcium ion concentration [GO:0051480]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0001917; GO:0005509; GO:0005813; GO:0005886; GO:0006816; GO:0007155; GO:0007156; GO:0007605; GO:0007626; GO:0016021; GO:0016339; GO:0032420; GO:0032426; GO:0042472; GO:0042491; GO:0045202; GO:0045494; GO:0048563; GO:0048839; GO:0050953; GO:0050957; GO:0051480; GO:0060088; GO:0060091; GO:0060122 0 0 0 PF00028; Q9BVG4 CHOYP_LOC100368495.1.1 m.9879 sp PBDC1_HUMAN 55.782 147 65 0 9 155 12 158 4.30E-57 181 PBDC1_HUMAN reviewed Protein PBDC1 (Polysaccharide biosynthesis domain-containing protein 1) PBDC1 CXorf26 Homo sapiens (Human) 233 0 0 0 0 0 PF04669; Q9BYB4 CHOYP_LOC100377395.1.1 m.15316 sp GNB1L_HUMAN 39.487 195 112 4 6 194 130 324 4.30E-42 147 GNB1L_HUMAN reviewed Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (DGCRK3) (WD repeat-containing protein 14) (WD40 repeat-containing protein deleted in VCFS) (WDVCF) GNB1L GY2 KIAA1645 WDR14 FKSG1 Homo sapiens (Human) 327 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; social behavior [GO:0035176] GO:0005737; GO:0007186; GO:0009898; GO:0035176; GO:0035556 0 0 0 PF00400; Q9BYE9 CHOYP_CDHR2.1.3 m.5359 sp CDHR2_HUMAN 40 85 49 1 17 99 14 98 4.30E-10 58.5 CDHR2_HUMAN reviewed Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24) CDHR2 PCDH24 PCLKC Homo sapiens (Human) 1310 cell-cell adhesion mediated by cadherin [GO:0044331]; epithelial cell differentiation [GO:0030855]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; intermicrovillar adhesion [GO:0090675]; negative regulation of cell growth involved in contact inhibition [GO:0060243]; regulation of microvillus length [GO:0032532] GO:0005509; GO:0005903; GO:0007156; GO:0016324; GO:0030054; GO:0030855; GO:0031526; GO:0031528; GO:0032532; GO:0044214; GO:0044331; GO:0050839; GO:0060243; GO:0070062; GO:0090675 0 0 0 PF00028; Q9D7Z6 CHOYP_LOC100935231.1.1 m.4081 sp CLCA1_MOUSE 32.271 251 156 9 3 250 9 248 4.30E-30 122 CLCA1_MOUSE reviewed Calcium-activated chloride channel regulator 1 (EC 3.4.-.-) (Calcium-activated chloride channel family member 3) (mCLCA3) (Protein gob-5) Clca1 Clca3 Gob5 Mus musculus (Mouse) 913 calcium ion transport [GO:0006816]; cellular response to hypoxia [GO:0071456]; chloride transport [GO:0006821] GO:0005229; GO:0005254; GO:0005615; GO:0005902; GO:0006816; GO:0006821; GO:0008237; GO:0016021; GO:0030141; GO:0031226; GO:0042589; GO:0046872; GO:0071456 0 0 0 PF08434;PF13519; Q9DB85 CHOYP_LOC100377968.1.1 m.10751 sp RRP8_MOUSE 39.691 388 215 5 202 571 71 457 4.30E-84 272 RRP8_MOUSE reviewed Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1 homolog) Rrp8 Mus musculus (Mouse) 457 "cellular response to glucose starvation [GO:0042149]; chromatin silencing at rDNA [GO:0000183]; covalent chromatin modification [GO:0016569]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of cell cycle arrest [GO:0071158]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0000183; GO:0005634; GO:0005677; GO:0005730; GO:0005737; GO:0005886; GO:0006351; GO:0006364; GO:0008757; GO:0016569; GO:0033553; GO:0035064; GO:0042149; GO:0044822; GO:0046015; GO:0071158; GO:0072332 0 0 0 PF05148; Q9MYM7 CHOYP_LOC100690528.1.1 m.48710 sp B3GT1_PONPY 39.3 257 150 5 87 339 61 315 4.30E-50 173 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; H2A0L1 CHOYP_TYRO1.2.6 m.42960 sp TYRO2_PINMG 31.051 409 219 18 117 485 71 456 4.31E-39 154 TYRO2_PINMG reviewed Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) 0 Pinctada margaritifera (Black-lipped pearl oyster) 456 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; J9VQZ4 CHOYP_LOC100209467.1.1 m.47674 sp LAC2_CRYNH 39.572 187 90 8 75 254 70 240 4.31E-28 115 LAC2_CRYNH reviewed Laccase-2 (EC 1.10.3.2) (Diphenol oxidase 2) LAC2 CNAG_03464 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 594 0 GO:0005507; GO:0005576; GO:0005618; GO:0052716 0 0 0 PF00394;PF07731;PF07732; O75095 CHOYP_CED1.29.29 m.66901 sp MEGF6_HUMAN 34.615 416 252 11 52 464 598 996 4.31E-57 211 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75382 CHOYP_BRAFLDRAFT_85511.15.23 m.46769 sp TRIM3_HUMAN 22.677 269 185 10 299 554 486 744 4.31E-10 66.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_88222.6.6 m.64090 sp TRIM3_HUMAN 25.61 246 143 8 219 444 482 707 4.31E-09 62.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O96064 CHOYP_MYSP.4.9 m.2305 sp MYSP_MYTGA 81.897 116 21 0 17 132 402 517 4.31E-42 150 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P49013 CHOYP_BRAFLDRAFT_73991.2.2 m.60726 sp FBP3_STRPU 51.556 225 109 0 482 706 216 440 4.31E-73 255 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P50476 CHOYP_HOX3.1.1 m.11325 sp HOX3_XENLA 48.421 190 69 5 76 262 168 331 4.31E-43 155 HOX3_XENLA reviewed Homeobox protein XHOX-3 xhox3 Xenopus laevis (African clawed frog) 388 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; P54850 CHOYP_LOC100879729.1.1 m.133 sp EMP1_RABIT 26.752 157 81 7 59 214 37 160 4.31E-07 51.6 EMP1_RABIT reviewed Epithelial membrane protein 1 (EMP-1) (Squamous cell-specific protein CL-20) (Tumor-associated membrane protein) EMP1 Oryctolagus cuniculus (Rabbit) 160 cell growth [GO:0016049] GO:0016021; GO:0016049 0 0 0 PF00822; P79385 CHOYP_SMP_135520.2.2 m.56973 sp MFGM_PIG 30.172 348 199 9 25 356 90 409 4.31E-43 161 MFGM_PIG reviewed Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) (Sperm surface protein SP47) (PP47) MFGE8 Sus scrofa (Pig) 409 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; single fertilization [GO:0007338] GO:0001525; GO:0002080; GO:0005576; GO:0007155; GO:0007338 0 0 0 PF00008;PF00754; Q04786 CHOYP_NEMVEDRAFT_V1G201552.1.6 m.2877 sp HEX_VIBVL 37.716 578 318 11 39 592 253 812 4.31E-130 405 HEX_VIBVL reviewed Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus 847 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; Q26648 CHOYP_BRAFLDRAFT_123537.1.2 m.28824 sp TKB1_STRPU 57.009 107 46 0 1 107 284 390 4.31E-31 116 TKB1_STRPU reviewed Tektin-B1 0 Strongylocentrotus purpuratus (Purple sea urchin) 400 0 GO:0005737; GO:0005874 0 0 0 0 Q2EMV9 CHOYP_LOC100487912.2.3 m.24317 sp PAR14_MOUSE 22.986 422 284 11 475 885 814 1205 4.31E-16 87.4 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q4A3R3 CHOYP_DMBT1.1.34 m.3075 sp DMBT1_PIG 57.547 106 41 3 215 319 229 331 4.31E-29 120 DMBT1_PIG reviewed Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) 1204 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0007275; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0035375; GO:0042589 0 0 0 PF00431;PF00530;PF00100; Q54JW9 CHOYP_LOC101162285.2.2 m.35051 sp IMPCT_DICDI 34.4 125 81 1 323 446 205 329 4.31E-12 70.5 IMPCT_DICDI reviewed Protein IMPACT homolog impact DDB_G0287757 Dictyostelium discoideum (Slime mold) 345 cell differentiation [GO:0030154]; cellular response to acidic pH [GO:0071468]; cellular response to amino acid starvation [GO:0034198]; cellular response to benomyl [GO:0072755]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of cell death [GO:0060548]; nervous system development [GO:0007399]; regulation of translation [GO:0006417] GO:0005737; GO:0006417; GO:0007399; GO:0030154; GO:0034198; GO:0060548; GO:0070301; GO:0071468; GO:0072755 0 0 0 PF05773;PF01205; Q5ND28 CHOYP_SCARF1.7.7 m.60587 sp SREC_MOUSE 42.056 107 58 3 3 107 253 357 4.31E-16 76.6 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q60847 CHOYP_BRAFLDRAFT_92090.3.7 m.42493 sp COCA1_MOUSE 41.081 185 103 4 39 220 436 617 4.31E-29 126 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q61330 CHOYP_CD22.1.4 m.31685 sp CNTN2_MOUSE 29.236 301 169 16 178 461 243 516 4.31E-13 75.9 CNTN2_MOUSE reviewed Contactin-2 (Axonal glycoprotein TAG-1) (Axonin-1) (Transient axonal glycoprotein 1) (TAX-1) Cntn2 Tax Mus musculus (Mouse) 1040 adult walking behavior [GO:0007628]; axonal fasciculation [GO:0007413]; axon guidance [GO:0007411]; cell-matrix adhesion [GO:0007160]; central nervous system myelination [GO:0022010]; cerebral cortex GABAergic interneuron migration [GO:0021853]; clustering of voltage-gated potassium channels [GO:0045163]; establishment of protein localization to juxtaparanode region of axon [GO:0071206]; learning [GO:0007612]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of neuron differentiation [GO:0045665]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; positive regulation of adenosine receptor signaling pathway [GO:0060168]; positive regulation of protein processing [GO:0010954]; presynaptic membrane organization [GO:0097090]; protein localization to juxtaparanode region of axon [GO:0071205]; receptor internalization [GO:0031623]; regulation of astrocyte differentiation [GO:0048710]; regulation of axon diameter [GO:0031133]; regulation of cell morphogenesis involved in differentiation [GO:0010769]; regulation of neuronal synaptic plasticity [GO:0048168] GO:0000226; GO:0001764; GO:0001948; GO:0005886; GO:0007160; GO:0007411; GO:0007413; GO:0007612; GO:0007628; GO:0009986; GO:0010769; GO:0010954; GO:0021853; GO:0022010; GO:0030246; GO:0030424; GO:0031133; GO:0031175; GO:0031225; GO:0031623; GO:0033268; GO:0043005; GO:0043025; GO:0043209; GO:0043621; GO:0044224; GO:0045163; GO:0045665; GO:0048168; GO:0048710; GO:0060168; GO:0071205; GO:0071206; GO:0097090 0 0 0 PF00041;PF07679; Q76B49 CHOYP_contig_045503 m.52951 sp CD63_FELCA 24.5 200 129 7 80 277 55 234 4.31E-08 56.2 CD63_FELCA reviewed CD63 antigen (CD antigen CD63) CD63 Felis catus (Cat) (Felis silvestris catus) 238 cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; endosome to melanosome transport [GO:0035646]; pigment granule maturation [GO:0048757]; positive regulation of endocytosis [GO:0045807]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005765; GO:0005887; GO:0007155; GO:0007160; GO:0007166; GO:0012505; GO:0015031; GO:0016477; GO:0031226; GO:0031902; GO:0035646; GO:0042470; GO:0045807; GO:0048757; GO:0070062; GO:0097487; GO:1900746; GO:2001046 0 0 0 PF00335; Q8BH60 CHOYP_GOPC.1.1 m.45489 sp GOPC_MOUSE 63.369 374 128 2 7 372 32 404 4.31E-165 476 GOPC_MOUSE reviewed Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) Gopc Mus musculus (Mouse) 463 autophagy [GO:0006914]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; spermatid nucleus differentiation [GO:0007289] GO:0000139; GO:0005109; GO:0005737; GO:0005794; GO:0005886; GO:0006914; GO:0007289; GO:0008022; GO:0014069; GO:0015031; GO:0016020; GO:0019905; GO:0030054; GO:0030140; GO:0030425; GO:0030695; GO:0042803; GO:0043234; GO:0044325; GO:0045202; GO:0045211; GO:0051260 0 0 0 PF00595; Q8K4Q6 CHOYP_LOC100703866.2.2 m.57740 sp NEIL1_MOUSE 49.231 325 152 5 1 317 1 320 4.31E-104 315 NEIL1_MOUSE reviewed Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (Nei homolog 1) (NEH1) (Nei-like protein 1) Neil1 Nei1 Mus musculus (Mouse) 389 base-excision repair [GO:0006284]; DNA repair [GO:0006281]; negative regulation of nuclease activity [GO:0032074]; nucleotide-excision repair [GO:0006289]; response to oxidative stress [GO:0006979] GO:0003684; GO:0003906; GO:0005634; GO:0005694; GO:0005737; GO:0005815; GO:0006281; GO:0006284; GO:0006289; GO:0006979; GO:0008022; GO:0008270; GO:0016798; GO:0016829; GO:0019104; GO:0032074 0 0 0 PF01149;PF06831;PF09292; Q8WXG9 CHOYP_GPR98.4.5 m.21295 sp GPR98_HUMAN 30.732 205 139 2 20 222 5401 5604 4.31E-21 96.3 GPR98_HUMAN reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Usher syndrome type-2C protein) (Very large G-protein coupled receptor 1) GPR98 KIAA0686 KIAA1943 MASS1 VLGR1 Homo sapiens (Human) 6306 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; maintenance of organ identity [GO:0048496]; nervous system development [GO:0007399]; neurological system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; single organismal cell-cell adhesion [GO:0016337]; visual perception [GO:0007601] GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0007166; GO:0007186; GO:0007399; GO:0007601; GO:0007605; GO:0009986; GO:0016020; GO:0016021; GO:0016337; GO:0032420; GO:0043235; GO:0045202; GO:0045494; GO:0048496; GO:0050877; GO:0050953; GO:0070062 0 0 0 PF00002;PF03160;PF03736; Q95YI5 CHOYP_NEMVEDRAFT_V1G162565.1.1 m.55821 sp US74C_DROME 56.27 311 133 2 1 308 51 361 4.31E-121 355 US74C_DROME reviewed UDP-sugar transporter UST74c (Protein fringe connection) frc UST74C CG3874 Drosophila melanogaster (Fruit fly) 373 compound eye morphogenesis [GO:0001745]; embryonic pattern specification [GO:0009880]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc pattern formation [GO:0007447]; segment polarity determination [GO:0007367]; sensory organ development [GO:0007423]; UDP-galactose transport [GO:0015785]; UDP-glucose transport [GO:0015786]; UDP-glucuronic acid transport [GO:0015787]; UDP-N-acetylglucosamine transport [GO:0015788]; UDP-xylose transport [GO:0015790] GO:0000139; GO:0001745; GO:0005459; GO:0005460; GO:0005461; GO:0005462; GO:0005464; GO:0005797; GO:0007367; GO:0007423; GO:0007447; GO:0007476; GO:0009880; GO:0015297; GO:0015785; GO:0015786; GO:0015787; GO:0015788; GO:0015790; GO:0016021 0 0 0 PF03151; Q9C040 CHOYP_TRIM2.59.59 m.66037 sp TRIM2_HUMAN 25.461 271 170 11 133 383 485 743 4.31E-09 62 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JLB4 CHOYP_LOC100705265.1.3 m.8841 sp CUBN_MOUSE 27.06 813 523 30 57 840 734 1505 4.31E-60 230 CUBN_MOUSE reviewed Cubilin (Intrinsic factor-cobalamin receptor) Cubn Ifcr Mus musculus (Mouse) 3623 cholesterol metabolic process [GO:0008203]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0005509; GO:0005737; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005903; GO:0005905; GO:0006898; GO:0008203; GO:0015031; GO:0016324; GO:0030139; GO:0031419; GO:0042803; GO:0042953; GO:0045177; GO:0070062 0 0 0 PF00431;PF00008;PF12947;PF07645;PF12661; Q9R1R2 CHOYP_BRAFLDRAFT_87340.5.6 m.64601 sp TRIM3_MOUSE 26.667 135 88 4 148 276 614 743 4.31E-06 53.1 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A2T7G9 CHOYP_LOC100377001.1.2 m.10821 sp HTAI2_PONPY 48.707 232 115 2 58 286 12 242 4.32E-74 230 HTAI2_PONPY reviewed Oxidoreductase HTATIP2 (EC 1.1.1.-) HTATIP2 Pongo pygmaeus (Bornean orangutan) 242 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154] GO:0001525; GO:0005635; GO:0005737; GO:0006915; GO:0016620; GO:0030154; GO:0051287 0 0 0 PF13460; E1BFR5 CHOYP_GWL.1.1 m.9657 sp GWL_BOVIN 74.843 159 37 1 15 173 28 183 4.32E-79 255 GWL_BOVIN reviewed Serine/threonine-protein kinase greatwall (GW) (GWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) MASTL GW GWL Bos taurus (Bovine) 883 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; G2/M transition of mitotic cell cycle [GO:0000086]; intracellular signal transduction [GO:0035556]; mitotic nuclear division [GO:0007067]; negative regulation of protein phosphatase type 2A activity [GO:0034048]; peptidyl-serine phosphorylation [GO:0018105] GO:0000086; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006974; GO:0007067; GO:0018105; GO:0032154; GO:0034048; GO:0035556; GO:0051301; GO:0051721 0 0 0 PF00069; O75095 CHOYP_MEGF6.13.59 m.24300 sp MEGF6_HUMAN 39.063 256 144 8 49 302 731 976 4.32E-35 138 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75197 CHOYP_LOC578656.12.15 m.56873 sp LRP5_HUMAN 25.789 919 609 29 87 965 56 941 4.32E-79 291 LRP5_HUMAN reviewed Low-density lipoprotein receptor-related protein 5 (LRP-5) LRP5 LR3 LRP7 Homo sapiens (Human) 1615 "adipose tissue development [GO:0060612]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in patterning of blood vessels [GO:1902262]; beta-catenin destruction complex disassembly [GO:1904886]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling involved in mammary gland development [GO:0060764]; cell migration involved in gastrulation [GO:0042074]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; glucose catabolic process [GO:0006007]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; osteoblast development [GO:0002076]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of bone remodeling [GO:0046850]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; retinal blood vessel morphogenesis [GO:0061304]; retina morphogenesis in camera-type eye [GO:0060042]; somatic stem cell population maintenance [GO:0035019]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]" GO:0001702; GO:0002053; GO:0002076; GO:0005739; GO:0005783; GO:0005886; GO:0006007; GO:0006897; GO:0008203; GO:0008217; GO:0008284; GO:0009952; GO:0016021; GO:0016055; GO:0017147; GO:0033690; GO:0035019; GO:0035426; GO:0042074; GO:0042632; GO:0042733; GO:0042813; GO:0042981; GO:0043235; GO:0044332; GO:0045600; GO:0045668; GO:0045840; GO:0045893; GO:0045944; GO:0046849; GO:0046850; GO:0048539; GO:0051091; GO:0060033; GO:0060042; GO:0060070; GO:0060349; GO:0060444; GO:0060612; GO:0060764; GO:0060828; GO:0061178; GO:0061304; GO:0071901; GO:0071936; GO:1902262; GO:1904886; GO:1904928; GO:1990851; GO:1990909 0 0 0 PF00057;PF00058; P13678 CHOYP_KPC2.2.3 m.23343 sp KPC3_DROME 65.957 94 32 0 31 124 273 366 4.32E-32 121 KPC3_DROME reviewed Protein kinase C (PKC) (EC 2.7.11.13) (dPKC98F) Pkc98E Pkc3 CG1954 Drosophila melanogaster (Fruit fly) 634 dorsal/ventral axis specification [GO:0009950]; Golgi organization [GO:0007030]; I-kappaB phosphorylation [GO:0007252]; lipid particle organization [GO:0034389]; long-term memory [GO:0007616]; negative regulation of cell proliferation [GO:0008285]; neuron projection morphogenesis [GO:0048812]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of peptide hormone secretion [GO:0090277]; protein phosphorylation [GO:0006468]; response to ethanol [GO:0045471] GO:0004674; GO:0004697; GO:0005524; GO:0005622; GO:0005886; GO:0006468; GO:0007030; GO:0007252; GO:0007616; GO:0008285; GO:0009950; GO:0018105; GO:0034389; GO:0040018; GO:0045471; GO:0046872; GO:0048812; GO:0090277 0 0 0 PF00130;PF00069;PF00433; P15941 CHOYP_RGD1561408.2.2 m.49667 sp MUC1_HUMAN 36.92 539 276 15 176 661 127 654 4.32E-28 127 MUC1_HUMAN reviewed Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] MUC1 PUM Homo sapiens (Human) 1255 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; O-glycan processing [GO:0016266]; positive regulation of histone H4 acetylation [GO:0090240]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]" GO:0000790; GO:0000978; GO:0002039; GO:0003712; GO:0005615; GO:0005796; GO:0005887; GO:0006977; GO:0006978; GO:0010944; GO:0016266; GO:0016324; GO:0031982; GO:0033629; GO:0036003; GO:0043618; GO:0070062; GO:0090240; GO:1902166 0 0 0 PF01390; P27169 CHOYP_LOC100378655.1.1 m.40440 sp PON1_HUMAN 38.75 320 176 6 43 348 42 355 4.32E-59 197 PON1_HUMAN reviewed Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) PON1 PON Homo sapiens (Human) 355 aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; cholesterol metabolic process [GO:0008203]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of binding [GO:0051099]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of transporter activity [GO:0032411]; response to external stimulus [GO:0009605]; response to fatty acid [GO:0070542]; response to fluoride [GO:1902617]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636] GO:0004063; GO:0004064; GO:0005509; GO:0005543; GO:0005576; GO:0005615; GO:0008203; GO:0009605; GO:0009636; GO:0010875; GO:0019439; GO:0031667; GO:0032411; GO:0034364; GO:0034366; GO:0042803; GO:0043231; GO:0046395; GO:0046434; GO:0046470; GO:0051099; GO:0070062; GO:0070542; GO:0072562; GO:0102007; GO:1902617 0 0 0 PF01731; P61354 CHOYP_RS3A.2.15 m.2681 sp RL27_RAT 82.353 136 24 0 351 486 1 136 4.32E-77 240 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; Q5ZQU0 CHOYP_LOC587890.1.1 m.2719 sp SNED1_RAT 40 160 91 5 3 158 754 912 4.32E-27 120 SNED1_RAT reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" Sned1 Rattus norvegicus (Rat) 1403 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00008;PF00041;PF12661;PF06119; Q8CI08 CHOYP_SLAI2.2.2 m.62741 sp SLAI2_MOUSE 32.192 292 151 11 1 245 1 292 4.32E-18 90.1 SLAI2_MOUSE reviewed SLAIN motif-containing protein 2 Slain2 Kiaa1458 Mus musculus (Mouse) 581 cytoplasmic microtubule organization [GO:0031122]; microtubule nucleation [GO:0007020]; positive regulation of microtubule polymerization [GO:0031116]; regulation of microtubule polymerization [GO:0031113] GO:0005737; GO:0005813; GO:0007020; GO:0015630; GO:0031113; GO:0031116; GO:0031122; GO:0035371 0 0 0 PF15301; Q8N475 CHOYP_LOC659040.1.2 m.20809 sp FSTL5_HUMAN 33.148 721 464 14 751 1461 131 843 4.32E-122 405 FSTL5_HUMAN reviewed Follistatin-related protein 5 (Follistatin-like protein 5) FSTL5 KIAA1263 Homo sapiens (Human) 847 0 GO:0005509; GO:0005576 0 0 0 PF07648; Q93075 CHOYP_LOC578076.1.1 m.17901 sp TATD2_HUMAN 40.672 268 158 1 625 892 495 761 4.32E-69 247 TATD2_HUMAN reviewed Putative deoxyribonuclease TATDN2 (EC 3.1.21.-) TATDN2 KIAA0218 Homo sapiens (Human) 761 DNA catabolic process [GO:0006308]; IRE1-mediated unfolded protein response [GO:0036498] GO:0004536; GO:0005634; GO:0005654; GO:0005737; GO:0006308; GO:0016888; GO:0036498; GO:0046872 0 0 0 PF01026; Q99NH0 CHOYP_YL100.1.1 m.23558 sp ANR17_MOUSE 31.818 330 190 12 469 775 241 558 4.32E-28 125 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9GZT8 CHOYP_NIF3L.1.2 m.28817 sp NIF3L_HUMAN 42.737 358 196 4 54 402 20 377 4.32E-99 302 NIF3L_HUMAN reviewed NIF3-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein) NIF3L1 ALS2CR1 MDS015 My018 Homo sapiens (Human) 377 "negative regulation of nucleic acid-templated transcription [GO:1903507]; neuron differentiation [GO:0030182]; positive regulation of transcription, DNA-templated [GO:0045893]" GO:0005634; GO:0005737; GO:0005739; GO:0008134; GO:0030182; GO:0042802; GO:0045893; GO:1903507 0 0 0 PF01784; Q9NQR1 CHOYP_IAP1.4.4 m.56083 sp KMT5A_HUMAN 37.324 142 80 5 31 168 257 393 4.32E-18 84.7 KMT5A_HUMAN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A PRSET7 SET07 SET8 SETD8 Homo sapiens (Human) 393 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006351; GO:0007067; GO:0016278; GO:0016279; GO:0018024; GO:0018026; GO:0042799; GO:0043516; GO:0045892; GO:0051301; GO:1901796 0 0 0 PF00856; Q9ULJ7 CHOYP_AASI_1435.4.35 m.23843 sp ANR50_HUMAN 31.863 612 394 5 19 610 494 1102 4.32E-82 285 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9W735 CHOYP_PRM1A.2.2 m.47566 sp PRM1A_DANRE 24.745 784 490 23 48 740 51 825 4.32E-54 204 PRM1A_DANRE reviewed Prominin-1-A (Prominin-like protein 1) prom1a proml1 Danio rerio (Zebrafish) (Brachydanio rerio) 826 0 GO:0005783; GO:0005793; GO:0005886; GO:0016021; GO:0016324; GO:0031528 0 0 0 PF05478; Q9XZC8 CHOYP_SEM2A.1.1 m.43497 sp SEM2A_SCHGR 32.055 652 390 21 35 651 28 661 4.32E-94 308 SEM2A_SCHGR reviewed Semaphorin-2A (Sema-2A) (Sema II) SEMA-2A Schistocerca gregaria (Desert locust) 697 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005576; GO:0007399; GO:0030154 0 0 0 PF01403; A7MBP4 CHOYP_LOC590756.6.6 m.63363 sp IFT46_DANRE 53.226 372 121 6 19 388 43 363 4.33E-112 336 IFT46_DANRE reviewed Intraflagellar transport protein 46 homolog ift46 Danio rerio (Zebrafish) (Brachydanio rerio) 384 cilium assembly [GO:0042384]; determination of ventral identity [GO:0048264]; intraciliary transport [GO:0042073]; pronephros development [GO:0048793]; retina development in camera-type eye [GO:0060041] GO:0005737; GO:0005813; GO:0030992; GO:0036064; GO:0042073; GO:0042384; GO:0048264; GO:0048793; GO:0060041 0 0 0 PF12317; A8XMW6 CHOYP_MEGF6.34.59 m.42864 sp CED1_CAEBR 42.365 203 104 7 194 390 676 871 4.33E-29 123 CED1_CAEBR reviewed Cell death abnormality protein 1 ced-1 CBG15845 Caenorhabditis briggsae 1134 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501] GO:0001845; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0045184 0 0 0 PF00053; E1BGN7 CHOYP_LOC682147.1.1 m.46334 sp CGAS_BOVIN 29.185 233 138 9 163 380 168 388 4.33E-12 70.9 CGAS_BOVIN reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) MB21D1 Bos taurus (Bovine) 498 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; E9Q555 CHOYP_RNF213.4.4 m.30433 sp RN213_MOUSE 21.847 563 370 19 3 538 4284 4803 4.33E-19 95.5 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 P52483 CHOYP_UB2E2.1.1 m.7143 sp UB2E3_MOUSE 75.148 169 40 1 14 180 39 207 4.33E-93 272 UB2E3_MOUSE reviewed Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcM2) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) Ube2e3 Ubce4 Ubcm2 Mus musculus (Mouse) 207 protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; regulation of growth [GO:0040008] GO:0004842; GO:0005524; GO:0005634; GO:0005737; GO:0040008; GO:0061631; GO:0070534; GO:0070936; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q10651 CHOYP_A4.2.3 m.7550 sp A4_CAEEL 32.658 444 271 11 274 691 3 444 4.33E-63 229 A4_CAEEL reviewed Beta-amyloid-like protein apl-1 C42D8.8 Caenorhabditis elegans 686 "body morphogenesis [GO:0010171]; cell differentiation [GO:0030154]; ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; nematode larval development [GO:0002119]; nervous system development [GO:0007399]" GO:0002119; GO:0005769; GO:0007399; GO:0008201; GO:0010171; GO:0016021; GO:0030154; GO:0031410; GO:0042395; GO:0043005; GO:0043025; GO:0046914 0 0 0 PF10515;PF12924;PF12925;PF02177; Q28FX0 CHOYP_LOC100533384.3.5 m.37350 sp ELAV3_XENTR 42.122 311 165 4 3 309 32 331 4.33E-78 244 ELAV3_XENTR reviewed ELAV-like protein 3 (Protein ElrC) elavl3 elrC TGas116i13.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 343 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0000166; GO:0003723; GO:0007399; GO:0030154; GO:0030529 0 0 0 PF00076; Q32PX7 CHOYP_BRAFLDRAFT_124476.4.4 m.66985 sp FUBP1_RAT 55.556 72 32 0 60 131 86 157 4.33E-21 90.9 FUBP1_RAT reviewed Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) Fubp1 Rattus norvegicus (Rat) 639 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF09005;PF00013; Q4H3K6 CHOYP_BRAFLDRAFT_99629.2.4 m.4649 sp FGFR_CIOIN 31.494 308 186 7 820 1110 369 668 4.33E-45 178 FGFR_CIOIN reviewed Fibroblast growth factor receptor (Ci-FGFR) (EC 2.7.10.1) FGFR Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) 747 positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0008284; GO:0016021 0 0 0 PF07679;PF07714; Q4UMH6 CHOYP_TVAG_080420.1.2 m.48892 sp Y381_RICFE 30.102 196 123 6 31 224 834 1017 4.33E-11 67.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q502M6 CHOYP_LOC755521.14.28 m.42725 sp ANR29_DANRE 37.433 187 117 0 4 190 43 229 4.33E-38 135 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5EAW4 CHOYP_MCM10.1.1 m.16587 sp MCM10_XENLA 36.762 661 348 21 389 998 210 851 4.33E-111 367 MCM10_XENLA reviewed Protein MCM10 homolog mcm10 Xenopus laevis (African clawed frog) 860 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260] GO:0003677; GO:0005634; GO:0006260; GO:0006974; GO:0046872 0 0 0 PF09332;PF09329; Q5RA23 CHOYP_MED8B.1.1 m.7003 sp NFYC_PONAB 73.469 147 38 1 16 162 8 153 4.33E-70 225 NFYC_PONAB reviewed Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) NFYC Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 335 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0006351; GO:0016602 0 0 0 PF00808; Q6DC60 CHOYP_ISCW_ISCW008681.1.1 m.3823 sp F219A_DANRE 37.333 150 75 6 35 166 38 186 4.33E-15 72.4 F219A_DANRE reviewed Protein FAM219A fam219a zgc:101028 Danio rerio (Zebrafish) (Brachydanio rerio) 186 0 0 0 0 0 PF15260; Q6PFY8 CHOYP_BRAFLDRAFT_80400.2.4 m.23710 sp TRI45_MOUSE 28.302 212 119 6 8 205 129 321 4.33E-12 71.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PFY8 CHOYP_TRI45.21.23 m.55183 sp TRI45_MOUSE 27.982 218 134 6 3 206 158 366 4.33E-10 64.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8BZ20 CHOYP_LOC100496973.8.8 m.63870 sp PAR12_MOUSE 30.286 175 106 5 117 284 75 240 4.33E-14 80.5 PAR12_MOUSE reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) 711 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q95LL8 CHOYP_LOC763537.1.1 m.46196 sp EFC12_MACFA 27.138 269 147 10 35 285 25 262 4.33E-14 79.3 EFC12_MACFA reviewed EF-hand calcium-binding domain-containing protein 12 EFCAB12 QtsA-20224 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 569 0 GO:0005509 0 0 0 0 Q96LL9 CHOYP_DNAJ-11.1.1 m.18882 sp DJC30_HUMAN 38.71 93 51 2 27 113 51 143 4.33E-12 66.6 DJC30_HUMAN reviewed DnaJ homolog subfamily C member 30 (Williams-Beuren syndrome chromosomal region 18 protein) DNAJC30 WBSCR18 Homo sapiens (Human) 226 0 GO:0005739 0 0 cd06257; PF00226; Q9HCJ3 CHOYP_RAVR1.1.1 m.62572 sp RAVR2_HUMAN 24.824 568 353 15 34 568 51 577 4.33E-36 149 RAVR2_HUMAN reviewed Ribonucleoprotein PTB-binding 2 (Protein raver-2) RAVER2 KIAA1579 Homo sapiens (Human) 691 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003676; GO:0005634; GO:0005737; GO:0044822 0 0 0 PF00076; Q9NZF1 CHOYP_LOC100373752.3.4 m.38546 sp PLAC8_HUMAN 31.461 89 56 2 61 149 25 108 4.33E-07 49.3 PLAC8_HUMAN reviewed Placenta-specific gene 8 protein (Protein C15) PLAC8 BM-004 Homo sapiens (Human) 115 brown fat cell differentiation [GO:0050873]; defense response to bacterium [GO:0042742]; negative regulation of apoptotic process [GO:0043066]; negative regulation of multicellular organism growth [GO:0040015]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cold [GO:0009409] GO:0003682; GO:0008284; GO:0009409; GO:0040015; GO:0042742; GO:0043066; GO:0045944; GO:0050873 0 0 0 PF04749; A0JNB1 CHOYP_LOC720058.1.1 m.11127 sp ZN227_BOVIN 29.318 440 273 11 699 1118 361 782 4.34E-44 176 ZN227_BOVIN reviewed Zinc finger protein 227 ZNF227 Bos taurus (Bovine) 787 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; A4IF63 CHOYP_BRAFLDRAFT_241726.14.22 m.33039 sp TRIM2_BOVIN 24.309 181 131 3 105 281 528 706 4.34E-07 54.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_TRIM2.8.59 m.18493 sp TRIM2_AILME 25 264 183 7 81 334 486 744 4.34E-16 82.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; I3LM39 CHOYP_NEMVEDRAFT_V1G196611.2.13 m.14366 sp CGAS_PIG 28.947 190 114 7 103 275 305 490 4.34E-08 59.3 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O35607 CHOYP_WIT.1.1 m.12465 sp BMPR2_MOUSE 40.974 493 260 10 211 698 60 526 4.34E-120 400 BMPR2_MOUSE reviewed Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (BRK-3) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) Bmpr2 Mus musculus (Mouse) 1038 anterior/posterior pattern specification [GO:0009952]; artery development [GO:0060840]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; brain development [GO:0007420]; cellular response to BMP stimulus [GO:0071773]; cellular response to starvation [GO:0009267]; chondrocyte development [GO:0002063]; endochondral bone morphogenesis [GO:0060350]; endothelial cell apoptotic process [GO:0072577]; endothelial cell proliferation [GO:0001935]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; maternal placenta development [GO:0001893]; mesoderm formation [GO:0001707]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vasoconstriction [GO:0045906]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteoglycan biosynthetic process [GO:0030166]; regulation of cell proliferation [GO:0042127]; regulation of lung blood pressure [GO:0014916]; retina vasculature development in camera-type eye [GO:0061298]; transcription from RNA polymerase II promoter [GO:0006366]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; venous blood vessel development [GO:0060841] GO:0001707; GO:0001893; GO:0001935; GO:0001938; GO:0001946; GO:0001974; GO:0002063; GO:0003085; GO:0004702; GO:0005524; GO:0005615; GO:0005737; GO:0005886; GO:0005887; GO:0005901; GO:0006366; GO:0007178; GO:0007420; GO:0009267; GO:0009925; GO:0009952; GO:0009986; GO:0010595; GO:0010634; GO:0010862; GO:0014069; GO:0014916; GO:0016324; GO:0030166; GO:0030308; GO:0030425; GO:0030501; GO:0030509; GO:0030513; GO:0036122; GO:0042127; GO:0043025; GO:0045669; GO:0045906; GO:0045944; GO:0046872; GO:0048010; GO:0048286; GO:0048842; GO:0060173; GO:0060350; GO:0060836; GO:0060840; GO:0060841; GO:0061036; GO:0061298; GO:0071773; GO:0072577; GO:0098821; GO:1902731; GO:2000279 0 0 0 PF01064;PF00069; O70309 CHOYP_LOC100562954.1.1 m.27429 sp ITB5_MOUSE 32.836 804 483 20 3 778 6 780 4.34E-152 467 ITB5_MOUSE reviewed Integrin beta-5 Itgb5 Mus musculus (Mouse) 798 cell-matrix adhesion [GO:0007160]; epithelial cell-cell adhesion [GO:0090136]; integrin-mediated signaling pathway [GO:0007229]; stress fiber assembly [GO:0043149]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0004872; GO:0005178; GO:0005886; GO:0005925; GO:0007160; GO:0007179; GO:0007229; GO:0009986; GO:0031252; GO:0034684; GO:0043149; GO:0043235; GO:0070062; GO:0090136 0 0 0 PF08725;PF07965;PF00362; P20273 CHOYP_DERE_GG24981.1.1 m.23973 sp CD22_HUMAN 23.666 431 283 16 127 529 131 543 4.34E-18 91.7 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P20397 CHOYP_CALM.31.50 m.48469 sp NUCL_XENLA 45.745 94 50 1 17 110 311 403 4.34E-16 77 NUCL_XENLA reviewed Nucleolin (Protein C23) ncl Xenopus laevis (African clawed frog) 651 0 GO:0000166; GO:0003677; GO:0003723; GO:0005730 0 0 0 PF00076; P29274 CHOYP_ADORA2B.1.1 m.14832 sp AA2AR_HUMAN 30.769 299 181 9 49 334 16 301 4.34E-25 108 AA2AR_HUMAN reviewed Adenosine receptor A2a ADORA2A ADORA2 Homo sapiens (Human) 412 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; cAMP biosynthetic process [GO:0006171]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular protein metabolic process [GO:0044267]; central nervous system development [GO:0007417]; inflammatory response [GO:0006954]; phagocytosis [GO:0006909]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; sensory perception [GO:0007600] GO:0001609; GO:0005886; GO:0005887; GO:0006171; GO:0006909; GO:0006915; GO:0006954; GO:0006968; GO:0007188; GO:0007267; GO:0007417; GO:0007596; GO:0007600; GO:0008015; GO:0010579; GO:0016020; GO:0019899; GO:0042802; GO:0044267 0 0 0 PF00001; P52899 CHOYP_PDHA1.1.1 m.42807 sp ODPA_CAEEL 65.903 349 117 2 103 450 27 374 4.34E-174 496 ODPA_CAEEL reviewed "Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1)" T05H10.6 Caenorhabditis elegans 397 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glycolytic process [GO:0006096] GO:0004739; GO:0005739; GO:0005759; GO:0006086; GO:0006096 0 0 0 PF00676; Q01240 CHOYP_LOC658201.1.1 m.42881 sp NF60_DORPE 42.405 158 85 2 8 161 29 184 4.34E-27 109 NF60_DORPE reviewed 60 kDa neurofilament protein (NF60) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 511 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q07409 CHOYP_CHL1.1.2 m.40531 sp CNTN3_MOUSE 26.992 389 257 14 43 424 36 404 4.34E-24 110 CNTN3_MOUSE reviewed Contactin-3 (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein) Cntn3 Pang Pcs Mus musculus (Mouse) 1028 cell adhesion [GO:0007155]; nervous system development [GO:0007399] GO:0005886; GO:0007155; GO:0007399; GO:0031225 0 0 0 PF00041;PF07679; Q08AE8 CHOYP_BRAFLDRAFT_68599.1.1 m.1463 sp SPIR1_HUMAN 41.549 284 142 8 7 275 88 362 4.34E-57 203 SPIR1_HUMAN reviewed Protein spire homolog 1 (Spir-1) SPIRE1 KIAA1135 SPIR1 Homo sapiens (Human) 756 actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005856; GO:0005886; GO:0005938; GO:0015031; GO:0016192; GO:0030036; GO:0030659; GO:0036089; GO:0040038; GO:0045010; GO:0046907; GO:0048471; GO:0051295; GO:0070649 0 0 0 PF16474; Q24248 CHOYP_IRO.3.4 m.22476 sp ARA_DROME 53.704 270 88 11 37 287 131 382 4.34E-68 231 ARA_DROME reviewed Homeobox protein araucan ara CG10571 Drosophila melanogaster (Fruit fly) 717 "compound eye morphogenesis [GO:0001745]; dendrite morphogenesis [GO:0048813]; equator specification [GO:0045317]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; muscle cell fate commitment [GO:0042693]; negative regulation of growth [GO:0045926]; notum cell fate specification [GO:0035310]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0001745; GO:0003705; GO:0005634; GO:0006351; GO:0007474; GO:0007476; GO:0035310; GO:0042693; GO:0043565; GO:0045317; GO:0045893; GO:0045926; GO:0045944; GO:0048813 0 0 0 PF05920; Q26636 CHOYP_NEMVEDRAFT_V1G180651.2.2 m.52927 sp CATL_SARPE 57.018 228 94 3 24 247 112 339 4.34E-92 278 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q5E960 CHOYP_LOC100372290.2.2 m.40459 sp S39A3_BOVIN 33.528 343 187 7 7 347 8 311 4.34E-55 186 S39A3_BOVIN reviewed Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) SLC39A3 ZIP3 Bos taurus (Bovine) 314 cell morphogenesis [GO:0000902]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; T cell homeostasis [GO:0043029]; zinc II ion transmembrane transport [GO:0071577] GO:0000902; GO:0001701; GO:0005385; GO:0005886; GO:0016021; GO:0043029; GO:0048701; GO:0060173; GO:0071577 0 0 0 PF02535; Q5R9Z1 CHOYP_ACT.19.27 m.53936 sp VPS29_PONAB 87.912 182 22 0 1 182 1 182 4.34E-122 345 VPS29_PONAB reviewed Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29) VPS29 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 182 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005769; GO:0005770; GO:0010008; GO:0015031; GO:0030904; GO:0046872; GO:1990126 0 0 0 PF12850; Q6P9H4 CHOYP_LOC100748006.2.2 m.62660 sp CNKR3_HUMAN 44.407 295 155 3 14 307 7 293 4.34E-72 244 CNKR3_HUMAN reviewed Connector enhancer of kinase suppressor of ras 3 (Connector enhancer of KSR 3) (CNK homolog protein 3) (CNK3) (CNKSR family member 3) (Maguin-like protein) CNKSR3 MAGI1 Homo sapiens (Human) 555 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; positive regulation of sodium ion transport [GO:0010765] GO:0005737; GO:0010765; GO:0016020; GO:0033137; GO:0070373 0 0 0 PF10534;PF06663;PF00595;PF00536; Q75N90 CHOYP_BRAFLDRAFT_98740.1.7 m.20423 sp FBN3_HUMAN 31.118 948 511 40 146 1012 1759 2645 4.34E-83 306 FBN3_HUMAN reviewed Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide] FBN3 KIAA1776 Homo sapiens (Human) 2809 anatomical structure morphogenesis [GO:0009653]; regulation of cellular response to growth factor stimulus [GO:0090287] GO:0005201; GO:0005509; GO:0005578; GO:0009653; GO:0031012; GO:0090287 0 0 0 PF12662;PF07645;PF12661;PF00683; Q8TD10 CHOYP_LOC100378067.1.1 m.66441 sp MIPO1_HUMAN 30.904 343 205 7 324 645 104 435 4.34E-34 138 MIPO1_HUMAN reviewed Mirror-image polydactyly gene 1 protein MIPOL1 Homo sapiens (Human) 442 0 GO:0005634 0 0 0 0 Q9QYT7 CHOYP_LOC100016710.1.1 m.27231 sp PIGQ_MOUSE 46.931 277 145 2 153 429 299 573 4.34E-77 253 PIGQ_MOUSE reviewed Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (MGpi1p) (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) Pigq Gpi1h Mgpi1 Mus musculus (Mouse) 581 GPI anchor biosynthetic process [GO:0006506] GO:0000506; GO:0006506; GO:0016021; GO:0017176 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF05024; Q9UGM3 CHOYP_LOC100633732.3.3 m.49313 sp DMBT1_HUMAN 45.283 212 106 6 369 574 494 701 4.34E-42 168 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9Z1J2 CHOYP_SMP_176970.1.1 m.45208 sp NEK4_MOUSE 37.77 278 169 4 266 542 11 285 4.34E-52 198 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; A6H8J1 CHOYP_PRRC1.1.1 m.6820 sp PRRCA_XENLA 55.411 231 103 0 143 373 212 442 4.35E-91 283 PRRCA_XENLA reviewed Protein PRRC1-A (Proline-rich and coiled-coil-containing protein 1-A) prrc1-a Xenopus laevis (African clawed frog) 442 0 GO:0005794 0 0 0 PF01931; B0UZC8 CHOYP_LOC101158638.2.2 m.27400 sp VWC2L_DANRE 37.895 95 54 3 31 124 116 206 4.35E-13 67.8 VWC2L_DANRE reviewed von Willebrand factor C domain-containing protein 2-like vwc2l si:ch211-207d8.1 Danio rerio (Zebrafish) (Brachydanio rerio) 223 nervous system development [GO:0007399] GO:0005576; GO:0007399; GO:0030054; GO:0045202 0 0 0 PF00093; B1WB06 CHOYP_LOC101066510.1.1 m.66179 sp MET24_XENTR 26.613 248 151 10 125 353 118 353 4.35E-11 67 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; O16011 CHOYP_DYAK_GE11656.2.2 m.54699 sp MBL_DROME 46.581 234 74 10 1 233 1 184 4.35E-51 174 MBL_DROME reviewed Protein muscleblind (Protein mindmelt) mbl mm CG33197 Drosophila melanogaster (Fruit fly) 297 "apoptotic process [GO:0006915]; compound eye photoreceptor cell differentiation [GO:0001751]; embryo development [GO:0009790]; eye development [GO:0001654]; imaginal disc-derived wing morphogenesis [GO:0007476]; muscle cell cellular homeostasis [GO:0046716]; muscle organ development [GO:0007517]; peripheral nervous system development [GO:0007422]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of female receptivity [GO:0045924]; regulation of gene expression [GO:0010468]; response to stimulus [GO:0050896]; rhabdomere development [GO:0042052]; somatic muscle development [GO:0007525]; visual perception [GO:0007601]" GO:0000381; GO:0001654; GO:0001751; GO:0003676; GO:0003677; GO:0005634; GO:0005737; GO:0006915; GO:0007422; GO:0007476; GO:0007517; GO:0007525; GO:0007601; GO:0009790; GO:0010468; GO:0030018; GO:0031673; GO:0042052; GO:0045924; GO:0046716; GO:0046872; GO:0048471; GO:0050896 0 0 0 0 O75382 CHOYP_BRAFLDRAFT_90331.2.2 m.46755 sp TRIM3_HUMAN 26.18 233 131 11 144 357 534 744 4.35E-10 64.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P21328 CHOYP_LOC100561123.1.28 m.1280 sp RTJK_DROME 27.358 424 260 13 3 410 442 833 4.35E-36 145 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; Q1RK13 CHOYP_LOC754728.3.6 m.39969 sp Y220_RICBR 40.854 164 86 7 5 160 448 608 4.35E-22 95.1 Y220_RICBR reviewed Putative ankyrin repeat protein RBE_0220 RBE_0220 Rickettsia bellii (strain RML369-C) 826 0 0 0 0 0 PF00023;PF12796; Q504Y3 CHOYP_BRAFLDRAFT_102742.1.1 m.49812 sp ZCPW2_HUMAN 38.235 136 79 3 33 167 27 158 4.35E-22 101 ZCPW2_HUMAN reviewed Zinc finger CW-type PWWP domain protein 2 ZCWPW2 Homo sapiens (Human) 356 0 GO:0008270 0 0 0 PF00855;PF07496; Q5R8Z4 CHOYP_PAK7.1.1 m.35662 sp PAK6_PONAB 46.328 708 309 18 26 695 1 675 4.35E-179 529 PAK6_PONAB reviewed Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) PAK6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 681 learning [GO:0007612]; locomotory behavior [GO:0007626]; memory [GO:0007613] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0007612; GO:0007613; GO:0007626 0 0 0 PF00786;PF00069; Q5XIU9 CHOYP_PGRMC1.1.1 m.38547 sp PGRC2_RAT 56.044 182 67 4 24 195 31 209 4.35E-64 200 PGRC2_RAT reviewed Membrane-associated progesterone receptor component 2 Pgrmc2 Rattus norvegicus (Rat) 217 0 GO:0005496; GO:0012505; GO:0016020; GO:0016021; GO:0020037 0 0 0 PF00173; Q7L0X2 CHOYP_LOC100378540.3.3 m.48871 sp ERIP6_HUMAN 31.552 393 223 9 230 611 271 628 4.35E-47 179 ERIP6_HUMAN reviewed Glutamate-rich protein 6 (Protein FAM194A) ERICH6 C3orf44 FAM194A Homo sapiens (Human) 663 0 0 0 0 0 PF14977; Q8BHA0 CHOYP_BRAFLDRAFT_105224.1.1 m.16777 sp IN80C_MOUSE 68.182 110 34 1 83 191 82 191 4.35E-48 158 IN80C_MOUSE reviewed INO80 complex subunit C Ino80c Mus musculus (Mouse) 191 "chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006281; GO:0006310; GO:0006338; GO:0006351; GO:0006355; GO:0031011; GO:0071339 0 0 0 PF08265; Q8NHV1 CHOYP_GIMA6.1.1 m.35333 sp GIMA7_HUMAN 34.375 224 133 3 360 583 7 216 4.35E-38 147 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8WMX5 CHOYP_LOC587947.1.1 m.24800 sp S15A1_CANLF 37.607 702 398 13 52 731 12 695 4.35E-157 475 S15A1_CANLF reviewed "Solute carrier family 15 member 1 (Intestinal H(+)/peptide cotransporter) (Oligopeptide transporter, small intestine isoform) (Peptide transporter 1)" SLC15A1 PEPT1 Canis lupus familiaris (Dog) (Canis familiaris) 708 protein transport [GO:0015031] GO:0015031; GO:0015198; GO:0015293; GO:0016021 0 0 cd06174; PF00854; Q8WZ42 CHOYP_TITIN.2.19 m.2379 sp TITIN_HUMAN 34.095 569 372 3 973 1539 12858 13425 4.35E-82 305 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q99L04 CHOYP_BRAFLDRAFT_205095.1.2 m.44643 sp DHRS1_MOUSE 61.429 210 72 1 3 212 5 205 4.35E-91 273 DHRS1_MOUSE reviewed Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) Dhrs1 D14ertd484e Mus musculus (Mouse) 313 0 GO:0005739; GO:0005743; GO:0005783; GO:0016491 0 0 0 PF00106; Q9BZH6 CHOYP_WDR11.1.2 m.49419 sp WDR11_HUMAN 31.02 461 291 5 2 454 710 1151 4.35E-71 247 WDR11_HUMAN reviewed WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15) WDR11 BRWD2 KIAA1351 WDR15 Homo sapiens (Human) 1224 0 GO:0005634; GO:0005737; GO:0005765; GO:0015630; GO:0016020; GO:0016021 0 0 0 0 A8MPX8 CHOYP_LOC100374333.1.2 m.38529 sp PP2D1_HUMAN 32.973 185 107 5 140 318 63 236 4.36E-20 95.9 PP2D1_HUMAN reviewed Protein phosphatase 2C-like domain-containing protein 1 PP2D1 C3orf48 Homo sapiens (Human) 630 0 GO:0004722 0 0 0 PF00481; B3EWZ6 CHOYP_LOC100372487.1.1 m.39712 sp MLRP2_ACRMI 29.155 343 195 18 207 525 725 1043 4.36E-21 103 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; Q15751 CHOYP_HERC1.1.2 m.26002 sp HERC1_HUMAN 62.871 202 75 0 1 202 4406 4607 4.36E-82 269 HERC1_HUMAN reviewed Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) HERC1 Homo sapiens (Human) 4861 cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of autophagy [GO:0010507]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; transport [GO:0006810] GO:0004842; GO:0005086; GO:0005737; GO:0005794; GO:0005829; GO:0006810; GO:0010507; GO:0016020; GO:0016874; GO:0021702; GO:0031175; GO:0050885 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632;PF00415;PF00622;PF00400; Q32PI6 CHOYP_DWIL_GK24328.1.1 m.16490 sp RM04_BOVIN 44.061 261 139 2 69 328 25 279 4.36E-69 221 RM04_BOVIN reviewed "39S ribosomal protein L4, mitochondrial (L4mt) (MRP-L4)" MRPL4 Bos taurus (Bovine) 294 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0005743; GO:0006412; GO:0022626; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF00573; Q55DF5 CHOYP_BRAFLDRAFT_121824.1.1 m.37419 sp JMJCD_DICDI 23.228 254 158 8 65 289 200 445 4.36E-07 55.5 JMJCD_DICDI reviewed JmjC domain-containing protein D (Jumonji domain-containing protein D) jcdD DDB_G0270906 Dictyostelium discoideum (Slime mold) 448 0 0 0 0 0 0 Q5XGW6 CHOYP_LOC100904959.1.1 m.23509 sp CHM4B_XENLA 66.471 170 53 3 2 171 56 221 4.36E-59 186 CHM4B_XENLA reviewed Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) chmp4b Xenopus laevis (African clawed frog) 222 exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; nuclear envelope reassembly [GO:0031468]; protein transport [GO:0015031]; vacuolar transport [GO:0007034] GO:0000281; GO:0000815; GO:0005635; GO:0005829; GO:0007034; GO:0010458; GO:0015031; GO:0030496; GO:0031468; GO:0031902; GO:0090148 0 0 0 PF03357; Q67XW5 CHOYP_MYCGRDRAFT_89575.1.12 m.780 sp UBP18_ARATH 46.774 62 24 2 113 170 52 108 4.36E-06 53.1 UBP18_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (Deubiquitinating enzyme 18) (AtUBP18) (Ubiquitin thioesterase 18) (Ubiquitin-specific-processing protease 18) UBP18 At4g31670 F28M20.140 Arabidopsis thaliana (Mouse-ear cress) 631 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016021; GO:0016579; GO:0036459; GO:0046872 0 0 0 PF00443;PF01753; Q6DGV1 CHOYP_CELF4.1.1 m.22429 sp CELF4_DANRE 58.168 404 117 13 4 370 132 520 4.36E-130 385 CELF4_DANRE reviewed CUGBP Elav-like family member 4 (CELF-4) (Bruno-like protein 4) (CUG-BP- and ETR-3-like factor 4) (RNA-binding protein BRUNOL-4) celf4 brunol4 zgc:92761 Danio rerio (Zebrafish) (Brachydanio rerio) 520 "mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]" GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0048026 0 0 0 PF00076; Q6PCG7 CHOYP_I2BLB.1.1 m.35739 sp I2BLB_XENLA 40.634 694 300 18 7 601 9 689 4.36E-147 444 I2BLB_XENLA reviewed Interferon regulatory factor 2-binding protein-like B (Enhanced at puberty protein 1 homolog B) irf2bpl-b eap1-b Xenopus laevis (African clawed frog) 690 0 GO:0005634; GO:0046872 0 0 0 PF11261; Q86BN8 CHOYP_BRAFLDRAFT_58222.1.1 m.24853 sp PTPM1_DROME 49.198 187 80 2 2 173 6 192 4.36E-59 186 PTPM1_DROME reviewed Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like protein) (Protein-tyrosine phosphatase mitochondrial 1-like protein) (EC 3.1.3.16) (EC 3.1.3.48) Plip CG10371 Drosophila melanogaster (Fruit fly) 200 dephosphorylation [GO:0016311]; neurogenesis [GO:0022008]; phosphatidylglycerol biosynthetic process [GO:0006655]; protein dephosphorylation [GO:0006470] GO:0004439; GO:0004725; GO:0005739; GO:0005743; GO:0006470; GO:0006655; GO:0008138; GO:0008962; GO:0016311; GO:0022008 PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2. 0 0 PF00782; Q8BKF1 CHOYP_LOC100488061.1.1 m.14543 sp RPOM_MOUSE 22.563 359 267 8 99 453 176 527 4.36E-14 78.6 RPOM_MOUSE reviewed "DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)" Polrmt Mus musculus (Mouse) 1207 transcription from mitochondrial promoter [GO:0006390] GO:0003677; GO:0003899; GO:0005739; GO:0006390; GO:0042645; GO:0044822 0 0 0 PF00940;PF14700; Q8IYB1 CHOYP_LOC100377311.7.14 m.36026 sp M21D2_HUMAN 33.077 130 83 3 27 154 270 397 4.36E-13 74.3 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8K0U4 CHOYP_LOC100372773.4.9 m.36635 sp HS12A_MOUSE 31.805 349 180 11 5 299 47 391 4.36E-40 152 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N2E2 CHOYP_CBR-APX-1.1.1 m.38987 sp VWDE_HUMAN 43.21 81 39 2 70 147 1316 1392 4.36E-09 61.6 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TAB3 CHOYP_PCD19.1.1 m.35560 sp PCD19_HUMAN 37.458 299 173 4 2 289 87 382 4.36E-54 193 PCD19_HUMAN reviewed Protocadherin-19 PCDH19 KIAA1313 Homo sapiens (Human) 1148 brain development [GO:0007420]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0007420; GO:0016021 0 0 0 PF00028;PF08266; Q9P215 CHOYP_LOC101169293.1.4 m.3699 sp POGK_HUMAN 39.844 128 73 3 555 679 197 323 4.36E-18 92 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9XZC0 CHOYP_TVAG_169080.2.2 m.57865 sp LCTA_LATTR 29.952 207 123 4 669 874 643 828 4.36E-14 80.5 LCTA_LATTR reviewed Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1) (Fragment) 0 Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) 1413 exocytosis [GO:0006887] GO:0005576; GO:0006887; GO:0016021; GO:0072556 0 0 0 PF12796;PF13606; A0JM12 CHOYP_MEG10.55.91 m.47508 sp MEG10_XENTR 38.516 283 148 13 1 275 429 693 4.37E-40 151 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; E9QAM5 CHOYP_LOC100184297.1.1 m.58042 sp HELZ2_MOUSE 37.5 136 78 4 10 142 2512 2643 4.37E-25 103 HELZ2_MOUSE reviewed Helicase with zinc finger domain 2 (EC 3.6.4.-) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) Helz2 Mus musculus (Mouse) 2947 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 O43390 CHOYP_HNRPR.1.2 m.44125 sp HNRPR_HUMAN 56.552 435 172 5 10 441 15 435 4.37E-163 484 HNRPR_HUMAN reviewed Heterogeneous nuclear ribonucleoprotein R (hnRNP R) HNRNPR HNRPR Homo sapiens (Human) 633 "circadian rhythm [GO:0007623]; gene expression [GO:0010467]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of catalytic activity [GO:0043086]; positive regulation of mRNA catabolic process [GO:0061014]" GO:0000166; GO:0000398; GO:0003723; GO:0003730; GO:0005654; GO:0005681; GO:0005783; GO:0006397; GO:0007623; GO:0010467; GO:0030425; GO:0030426; GO:0030529; GO:0043086; GO:0043679; GO:0044822; GO:0061014; GO:0061157; GO:0071013 0 0 0 PF00076; P04323 CHOYP_LOC754648.1.3 m.12631 sp POL3_DROME 41.895 475 259 8 999 1463 157 624 4.37E-112 383 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P15330 CHOYP_DWIL_GK10525.1.1 m.56074 sp DORS_DROME 56.028 282 120 4 133 411 48 328 4.37E-98 326 DORS_DROME reviewed Embryonic polarity protein dorsal dl CG6667 Drosophila melanogaster (Fruit fly) 999 "anterior/posterior pattern specification [GO:0009952]; defense response [GO:0006952]; dorsal/ventral axis specification [GO:0009950]; dorsal/ventral pattern formation [GO:0009953]; ectodermal cell fate specification [GO:0001715]; ectoderm development [GO:0007398]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ cell migration [GO:0008354]; heart development [GO:0007507]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; immune response [GO:0006955]; melanization defense response [GO:0035006]; mesodermal cell fate specification [GO:0007501]; mesoderm development [GO:0007498]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; peripheral nervous system neuron development [GO:0048935]; plasmatocyte differentiation [GO:0042387]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of glucose metabolic process [GO:0010906]; regulation of hemocyte proliferation [GO:0035206]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; Toll signaling pathway [GO:0008063]; ventral cord development [GO:0007419]" GO:0000122; GO:0000381; GO:0000977; GO:0001077; GO:0001715; GO:0003682; GO:0005634; GO:0005737; GO:0005829; GO:0006355; GO:0006952; GO:0006955; GO:0006964; GO:0007249; GO:0007369; GO:0007398; GO:0007419; GO:0007498; GO:0007501; GO:0007507; GO:0008063; GO:0008354; GO:0009950; GO:0009952; GO:0009953; GO:0010004; GO:0010629; GO:0010906; GO:0031594; GO:0033256; GO:0034097; GO:0035006; GO:0035206; GO:0038061; GO:0042387; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0048935; GO:0070379; GO:0070491 0 0 0 PF16179;PF00554; P21613 CHOYP_KINH.3.9 m.21632 sp KINH_DORPE 64.706 238 66 6 105 342 712 931 4.37E-78 261 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P22105 CHOYP_DMOJ_GI17886.1.1 m.31058 sp TENX_HUMAN 29.545 264 130 16 149 384 208 443 4.37E-16 84 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P42297 CHOYP_YAHB.1.1 m.25422 sp YXIE_BACSU 31.126 151 92 4 9 153 4 148 4.37E-12 63.2 YXIE_BACSU reviewed Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) 148 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P48148 CHOYP_AGAP_AGAP005160.1.1 m.54583 sp RHO1_DROME 75.648 193 46 1 17 209 1 192 4.37E-107 308 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; P50464 CHOYP_PHUM_PHUM446340.1.1 m.9294 sp UNC97_CAEEL 64.939 328 111 2 99 422 17 344 4.37E-162 462 UNC97_CAEEL reviewed LIM domain-containing protein unc-97 (PINCH homolog) (Uncoordinated protein 97) unc-97 F14D12.2 Caenorhabditis elegans 348 cell-cell junction organization [GO:0045216]; muscle organ development [GO:0007517]; sensory perception of mechanical stimulus [GO:0050954] GO:0005634; GO:0005654; GO:0005912; GO:0007517; GO:0008270; GO:0009925; GO:0017022; GO:0031430; GO:0045216; GO:0050954; GO:0055120 0 0 0 PF00412; P53590 CHOYP_SUCB2.1.1 m.7164 sp SUCB2_PIG 63.797 395 143 0 49 443 33 427 4.37E-180 513 SUCB2_PIG reviewed "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) (Fragment)" SUCLG2 Sus scrofa (Pig) 433 tricarboxylic acid cycle [GO:0006099] GO:0004776; GO:0005524; GO:0005525; GO:0005739; GO:0006099 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle. 0 0 PF08442;PF00549; Q09225 CHOYP_BRAFLDRAFT_66621.4.4 m.57466 sp NRF6_CAEEL 27.857 700 374 21 103 723 153 800 4.37E-78 270 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q10982 CHOYP_LOC100487974.1.1 m.60625 sp FUT2_PIG 29.496 278 177 6 68 339 67 331 4.37E-32 125 FUT2_PIG reviewed "Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Alpha(1,2)FT 2) (Fucosyltransferase 2) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2)" FUT2 Sus scrofa (Pig) 340 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q27928 CHOYP_GPDA.2.2 m.30755 sp GPDA_DROPS 68.421 361 109 2 31 387 1 360 4.37E-173 489 GPDA_DROPS reviewed "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)" Gpdh Drosophila pseudoobscura pseudoobscura (Fruit fly) 360 carbohydrate metabolic process [GO:0005975]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerophospholipid metabolic process [GO:0006650] GO:0004367; GO:0005975; GO:0006650; GO:0009331; GO:0046168; GO:0051287 PATHWAY: Phospholipid metabolism; alpha-glycerophosphate cycle. 0 0 PF07479;PF01210; Q502W6 CHOYP_BRAFLDRAFT_117157.3.3 m.53390 sp VWA3B_HUMAN 40.353 679 394 5 69 741 27 700 4.37E-165 528 VWA3B_HUMAN reviewed von Willebrand factor A domain-containing protein 3B VWA3B Homo sapiens (Human) 1294 0 0 0 0 0 PF15057;PF13768; Q5EAR5 CHOYP_BRAFLDRAFT_274539.1.3 m.25560 sp TRPT1_DANRE 49.524 210 99 4 172 377 18 224 4.37E-60 205 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q5T1A1 CHOYP_LOC664592.1.1 m.49598 sp DCST2_HUMAN 30.758 660 445 7 105 759 13 665 4.37E-103 342 DCST2_HUMAN reviewed DC-STAMP domain-containing protein 2 DCST2 Homo sapiens (Human) 773 0 GO:0016021 0 0 0 PF07782; Q6P9I7 CHOYP_LOC100073775.1.1 m.50701 sp SMC6_XENLA 49.721 179 87 2 2 180 953 1128 4.37E-52 181 SMC6_XENLA reviewed Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (xSMC6) smc6 smc6l1 Xenopus laevis (African clawed frog) 1128 cellular senescence [GO:0090398]; double-strand break repair via homologous recombination [GO:0000724]; resolution of recombination intermediates [GO:0071139]; telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000724; GO:0000781; GO:0005524; GO:0016605; GO:0030915; GO:0071139; GO:0090398 0 0 0 PF02463; Q8BGS1 CHOYP_AGAP_AGAP004136.3.3 m.44418 sp E41L5_MOUSE 67.257 339 111 0 31 369 40 378 4.37E-166 507 E41L5_MOUSE reviewed Band 4.1-like protein 5 Epb41l5 Epb4.1l5 Kiaa1548 Mus musculus (Mouse) 731 "actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; apical constriction [GO:0003383]; axial mesoderm development [GO:0048318]; axial mesoderm morphogenesis [GO:0048319]; cell morphogenesis involved in differentiation [GO:0000904]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ectoderm development [GO:0007398]; embryonic foregut morphogenesis [GO:0048617]; endoderm development [GO:0007492]; epithelial cell morphogenesis [GO:0003382]; epithelial to mesenchymal transition [GO:0001837]; in utero embryonic development [GO:0001701]; left/right axis specification [GO:0070986]; mesoderm development [GO:0007498]; mesoderm migration involved in gastrulation [GO:0007509]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of protein binding [GO:0032091]; neural plate morphogenesis [GO:0001839]; paraxial mesoderm development [GO:0048339]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of protein binding [GO:0032092]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of establishment of protein localization [GO:0070201]; somite rostral/caudal axis specification [GO:0032525]; somitogenesis [GO:0001756]; substrate-dependent cell migration, cell attachment to substrate [GO:0006931]; unidimensional cell growth [GO:0009826]" GO:0000904; GO:0001701; GO:0001756; GO:0001837; GO:0001839; GO:0001954; GO:0003382; GO:0003383; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0005925; GO:0006931; GO:0007398; GO:0007492; GO:0007498; GO:0007509; GO:0009826; GO:0010608; GO:0010634; GO:0010718; GO:0019898; GO:0019904; GO:0022408; GO:0030036; GO:0031032; GO:0031252; GO:0032091; GO:0032092; GO:0032525; GO:0032587; GO:0048318; GO:0048319; GO:0048339; GO:0048617; GO:0051894; GO:0070201; GO:0070986; GO:0071560 0 0 0 PF08736;PF09380;PF00373;PF09379; Q8C790 CHOYP_BRAFLDRAFT_239751.3.3 m.46416 sp F221A_MOUSE 56.329 316 118 5 8 323 4 299 4.37E-123 358 F221A_MOUSE reviewed Protein FAM221A Fam221a Mus musculus (Mouse) 301 0 0 0 0 0 PF14753; Q91WD2 CHOYP_LOC100877549.1.1 m.8321 sp TRPV6_MOUSE 28.765 591 366 15 94 654 84 649 4.37E-64 236 TRPV6_MOUSE reviewed Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) Trpv6 Mus musculus (Mouse) 767 calcium ion homeostasis [GO:0055074]; calcium ion import into cell [GO:1990035]; calcium ion transport [GO:0006816]; parathyroid hormone secretion [GO:0035898] GO:0005262; GO:0005516; GO:0005886; GO:0005887; GO:0006816; GO:0016021; GO:0035898; GO:0055074; GO:0070062; GO:1990035 0 0 0 PF12796;PF00520; Q9QYP2 CHOYP_TRIADDRAFT_55942.1.1 m.47232 sp CELR2_RAT 21.853 421 268 15 348 721 1201 1607 4.37E-20 99.8 CELR2_RAT reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) (Fragment) Celsr2 Megf3 Rattus norvegicus (Rat) 2144 cell surface receptor signaling pathway [GO:0007166]; dendrite morphogenesis [GO:0048813]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell-cell adhesion [GO:0022407]; spermatogenesis [GO:0007283] GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007166; GO:0007283; GO:0016021; GO:0022407; GO:0048813 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9Y2Y1 CHOYP_POLR3K.1.1 m.8423 sp RPC10_HUMAN 79.63 108 22 0 21 128 1 108 4.37E-64 193 RPC10_HUMAN reviewed DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11) POLR3K RPC11 My010 Homo sapiens (Human) 108 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of type I interferon production [GO:0032481]; termination of RNA polymerase III transcription [GO:0006386]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003676; GO:0003899; GO:0005654; GO:0005666; GO:0005730; GO:0005829; GO:0006383; GO:0006386; GO:0008270; GO:0032481; GO:0045087; GO:0051607 0 0 0 PF02150;PF01096; Q9Z2A5 CHOYP_ATE1.1.3 m.6901 sp ATE1_MOUSE 58.824 221 88 2 1 220 298 516 4.37E-84 261 ATE1_MOUSE reviewed Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (EC 2.3.2.8) (Arginine-tRNA--protein transferase 1) Ate1 Mus musculus (Mouse) 516 protein arginylation [GO:0016598] GO:0004057; GO:0005634; GO:0005737; GO:0016598 0 0 0 PF04377;PF04376; A3KMP2 CHOYP_BRAFLDRAFT_113725.1.1 m.10515 sp TTC38_MOUSE 51.613 124 60 0 12 135 4 127 4.38E-39 139 TTC38_MOUSE reviewed Tetratricopeptide repeat protein 38 (TPR repeat protein 38) Ttc38 Mus musculus (Mouse) 465 0 GO:0070062 0 0 0 0 P02553 CHOYP_TBA.5.6 m.37448 sp TBA_LYTPI 98.667 75 1 0 59 133 39 113 4.38E-50 159 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P0CB96 CHOYP_LOC100694882.2.2 m.30516 sp NDUS4_PONPY 66.667 96 32 0 43 138 49 144 4.38E-45 148 NDUS4_PONPY reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit)" NDUFS4 Pongo pygmaeus (Bornean orangutan) 175 brain development [GO:0007420]; cAMP-mediated signaling [GO:0019933]; cellular respiration [GO:0045333]; electron transport chain [GO:0022900]; mitochondrial respiratory chain complex I assembly [GO:0032981]; positive regulation of fibroblast proliferation [GO:0048146]; reactive oxygen species metabolic process [GO:0072593]; response to cAMP [GO:0051591] GO:0005747; GO:0007420; GO:0016651; GO:0019933; GO:0022900; GO:0032981; GO:0045333; GO:0048146; GO:0051591; GO:0072593 0 0 0 PF04800; P16157 CHOYP_TVAG_168010.42.45 m.61146 sp ANK1_HUMAN 32.464 422 263 6 100 506 96 510 4.38E-58 211 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q3UMF9 CHOYP_LOC100377010.11.16 m.41735 sp FAXC_MOUSE 35.019 257 153 4 31 276 89 342 4.38E-52 179 FAXC_MOUSE reviewed Failed axon connections homolog Faxc Mus musculus (Mouse) 409 0 GO:0016021 0 0 0 PF17171;PF17172; Q54KA7 CHOYP_AFUA_1G01020.24.50 m.32941 sp SECG_DICDI 41.379 116 68 0 7 122 351 466 4.38E-19 84.7 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5ND28 CHOYP_MEGF6.28.59 m.37722 sp SREC_MOUSE 29.603 277 129 13 101 337 144 394 4.38E-16 84.3 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RBU8 CHOYP_LOC100748395.1.7 m.12077 sp ROA2_PONAB 53.684 190 88 0 68 257 16 205 4.38E-67 215 ROA2_PONAB reviewed Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 353 "miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; primary miRNA processing [GO:0031053]" GO:0000166; GO:0000398; GO:0003730; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006406; GO:0030529; GO:0031053; GO:0035198; GO:0043047; GO:0070062; GO:1990247; GO:1990428 0 0 0 PF00076; Q5U312 CHOYP_LOC100371977.1.1 m.21628 sp RAI14_RAT 41.176 221 128 1 17 237 7 225 4.38E-42 170 RAI14_RAT reviewed Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) Rai14 Rattus norvegicus (Rat) 978 0 GO:0005654; GO:0005739; GO:0005938; GO:0015629 0 0 0 PF12796; Q5UQ35 CHOYP_BRAFLDRAFT_126767.3.3 m.30743 sp YR811_MIMIV 25.521 192 120 6 34 211 5 187 4.38E-08 59.7 YR811_MIMIV reviewed Putative ariadne-like RING finger protein R811 MIMI_R811 Acanthamoeba polyphaga mimivirus (APMV) 990 0 GO:0008270 0 0 0 PF01485; Q63186 CHOYP_BRAFLDRAFT_240825.1.1 m.43452 sp EI2BD_RAT 55.862 435 176 4 51 485 95 513 4.38E-171 495 EI2BD_RAT reviewed Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta) Eif2b4 Eif2bd Rattus norvegicus (Rat) 524 cellular response to stimulus [GO:0051716]; hippocampus development [GO:0021766]; myelination [GO:0042552]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translational initiation [GO:0006413] GO:0001541; GO:0003743; GO:0005085; GO:0005737; GO:0005851; GO:0006413; GO:0009408; GO:0009749; GO:0014003; GO:0021766; GO:0031369; GO:0042552; GO:0043434; GO:0051716; GO:1905098 0 0 0 PF01008; Q6DGZ3 CHOYP_THOC7.1.1 m.6771 sp THOC7_DANRE 59.375 192 78 0 2 193 3 194 4.38E-80 240 THOC7_DANRE reviewed THO complex subunit 7 homolog thoc7 zgc:92711 Danio rerio (Zebrafish) (Brachydanio rerio) 202 mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; transcription elongation from RNA polymerase II promoter [GO:0006368] GO:0000445; GO:0000446; GO:0000781; GO:0003676; GO:0003723; GO:0005634; GO:0005737; GO:0006368; GO:0006397; GO:0006406; GO:0008380; GO:0016607 0 0 0 PF05615; Q6PFY8 CHOYP_LOC100367817.1.7 m.39918 sp TRI45_MOUSE 28.139 231 138 6 15 229 103 321 4.38E-15 79.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PJF5 CHOYP_RHDF1.3.3 m.54744 sp RHDF2_HUMAN 40.412 485 260 8 241 717 388 851 4.38E-127 401 RHDF2_HUMAN reviewed Inactive rhomboid protein 2 (iRhom2) (Rhomboid 5 homolog 2) (Rhomboid family member 2) (Rhomboid veinlet-like protein 5) (Rhomboid veinlet-like protein 6) RHBDF2 IRHOM2 RHBDL5 RHBDL6 Homo sapiens (Human) 856 negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; proteolysis [GO:0006508]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of protein secretion [GO:0050708] GO:0005789; GO:0005886; GO:0006508; GO:0015031; GO:0016021; GO:0042058; GO:0050708; GO:0050709 0 0 0 PF01694;PF12595; Q704V6 CHOYP_TLR6.2.2 m.45452 sp TLR6_BOVIN 31.627 332 200 11 1 324 455 767 4.38E-35 138 TLR6_BOVIN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Bos taurus (Bovine) 793 cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0002755; GO:0004888; GO:0005794; GO:0005887; GO:0006954; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0042088; GO:0042496; GO:0042742; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; Q920P5 CHOYP_LOC662408.1.1 m.44394 sp KAD5_MOUSE 30.617 454 269 10 1 441 142 562 4.38E-67 228 KAD5_MOUSE reviewed Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) Ak5 Mus musculus (Mouse) 562 ATP metabolic process [GO:0046034]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142] GO:0004017; GO:0004550; GO:0005524; GO:0005737; GO:0005815; GO:0006165; GO:0009142; GO:0019206; GO:0046034 0 0 cd01428; 0 Q95SX7 CHOYP_LOC100561123.15.28 m.18164 sp RTBS_DROME 28.834 326 195 9 163 474 357 659 4.38E-20 97.4 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q9P0W8 CHOYP_BRAFLDRAFT_65681.1.1 m.445 sp SPAT7_HUMAN 25.63 476 257 18 20 467 22 428 4.38E-23 107 SPAT7_HUMAN reviewed Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3) SPATA7 HSD3 Homo sapiens (Human) 599 photoreceptor cell maintenance [GO:0045494]; protein localization to photoreceptor connecting cilium [GO:1903621]; protein localization to photoreceptor outer segment [GO:1903546]; response to stimulus [GO:0050896]; spermatogenesis [GO:0007283]; visual perception [GO:0007601] GO:0005737; GO:0005930; GO:0007283; GO:0007601; GO:0015630; GO:0032391; GO:0036064; GO:0045494; GO:0050896; GO:1903546; GO:1903621 0 0 0 PF15244; O88974 CHOYP_LOC100372058.1.2 m.3491 sp SETB1_MOUSE 46.809 47 25 0 132 178 1202 1248 4.39E-07 53.5 SETB1_MOUSE reviewed Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (SET domain bifurcated 1) Setdb1 Eset Kiaa0067 Mus musculus (Mouse) 1307 "bone development [GO:0060348]; histone H3-K9 trimethylation [GO:0036124]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; Ras protein signal transduction [GO:0007265]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001833; GO:0003677; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005886; GO:0006351; GO:0007265; GO:0008270; GO:0018024; GO:0036124; GO:0043231; GO:0060348; GO:0090309; GO:1990841 0 0 0 PF01429;PF05033;PF00856; P0CT43 CHOYP_LOC100496211.1.1 m.33469 sp TF28_SCHPO 25.352 142 92 3 2 143 455 582 4.39E-06 48.9 TF28_SCHPO reviewed Transposon Tf2-8 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-8 Tf2-9 SPAC13D1.02c SPAC19D5.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P14831 CHOYP_LOC100377119.1.1 m.44037 sp SODCP_SOLLC 28.07 171 104 6 243 413 33 184 4.39E-10 64.3 SODCP_SOLLC reviewed "Superoxide dismutase [Cu-Zn], chloroplastic (EC 1.15.1.1)" SODCP.2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) 217 cellular response to high light intensity [GO:0071486]; removal of superoxide radicals [GO:0019430] GO:0004784; GO:0005507; GO:0005737; GO:0008270; GO:0009507; GO:0019430; GO:0071486 0 0 cd00305; PF00080; P18700 CHOYP_LOC100366486.1.1 m.15011 sp TBB_STRPU 96.825 189 6 0 1 189 9 197 4.39E-138 390 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P49916 CHOYP_RS8.5.14 m.32290 sp DNLI3_HUMAN 58.511 94 39 0 2 95 604 697 4.39E-32 123 DNLI3_HUMAN reviewed DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) LIG3 Homo sapiens (Human) 1009 "base-excision repair, DNA ligation [GO:0006288]; cell cycle [GO:0007049]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA ligation [GO:0006266]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; double-strand break repair via alternative nonhomologous end joining [GO:0097681]; double-strand break repair via homologous recombination [GO:0000724]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of mitochondrial DNA replication [GO:0090298]; nucleotide-excision repair, DNA gap filling [GO:0006297]; transcription-coupled nucleotide-excision repair [GO:0006283]" GO:0000724; GO:0003677; GO:0003909; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0006260; GO:0006266; GO:0006283; GO:0006288; GO:0006297; GO:0006302; GO:0007005; GO:0007049; GO:0008270; GO:0043504; GO:0051301; GO:0070421; GO:0071897; GO:0090298; GO:0097681 0 0 0 PF04679;PF01068;PF04675;PF16759;PF00645; P52655 CHOYP_TF2AA.1.1 m.50726 sp TF2AA_HUMAN 69.444 108 32 1 192 299 270 376 4.39E-36 135 TF2AA_HUMAN reviewed Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] GTF2A1 TF2A1 Homo sapiens (Human) 376 "regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0003677; GO:0003713; GO:0005654; GO:0005672; GO:0005737; GO:0006355; GO:0006366; GO:0006367; GO:0006368; GO:0008134; GO:0017025; GO:0042795; GO:0046982 0 0 cd07976; PF03153; Q3ZBG9 CHOYP_LOC100900116.1.1 m.30300 sp PLS2_BOVIN 23.695 249 176 7 13 259 55 291 4.39E-09 59.3 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q5H8A4 CHOYP_PIGG.1.1 m.16860 sp PIGG_HUMAN 37.719 912 485 24 57 897 65 964 4.39E-161 500 PIGG_HUMAN reviewed GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) PIGG GPI7 UNQ1930/PRO4405 Homo sapiens (Human) 983 GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254] GO:0005783; GO:0005789; GO:0006506; GO:0016020; GO:0016254; GO:0016780; GO:0030176; GO:0051267 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF01663; Q5R611 CHOYP_BRAFLDRAFT_119296.11.16 m.47431 sp HRSL3_PONAB 31.737 167 105 3 11 174 2 162 4.39E-21 87.4 HRSL3_PONAB reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) PLA2G16 HRASLS3 HREV107 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 162 lipid catabolic process [GO:0016042] GO:0004623; GO:0008970; GO:0016021; GO:0016042; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; Q5U581 CHOYP_MTRAB.1.1 m.63789 sp MTRAA_XENLA 32.697 786 426 20 40 763 10 754 4.39E-115 369 MTRAA_XENLA reviewed Myotubularin-related protein 10-A mtmr10-a Xenopus laevis (African clawed frog) 765 0 0 0 0 0 PF12578;PF06602; Q7ZXX1 CHOYP_PVRL1.1.3 m.917 sp CADM3_XENLA 27.397 292 176 11 160 450 90 346 4.39E-15 80.1 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q8C525 CHOYP_LOC100377311.6.14 m.34688 sp M21D2_MOUSE 23.256 344 224 10 79 417 26 334 4.39E-16 84.7 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.34.34 m.62323 sp VWDE_HUMAN 24.217 607 365 24 52 608 54 615 4.39E-22 107 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8W257 CHOYP_LOC100208937.3.4 m.12305 sp PFI_PTIFI 23.203 487 337 12 58 520 24 497 4.39E-17 87.4 PFI_PTIFI reviewed Polyenoic fatty acid isomerase (PFI) (EC 5.3.3.13) 0 Ptilota filicina (Red alga) 500 0 GO:0016491; GO:0034016 0 0 0 PF01593; Q92193 CHOYP_ACT2.2.3 m.14617 sp ACT_CRAVI 94.4 125 7 0 1 125 39 163 4.39E-81 244 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96DH6 CHOYP_MSIR6.1.1 m.20150 sp MSI2H_HUMAN 67.355 242 53 6 31 266 22 243 4.39E-104 308 MSI2H_HUMAN reviewed RNA-binding protein Musashi homolog 2 (Musashi-2) MSI2 Homo sapiens (Human) 328 stem cell development [GO:0048864] GO:0000166; GO:0005737; GO:0005844; GO:0008266; GO:0044822; GO:0048864 0 0 0 PF00076; Q99417 CHOYP_LOC100369611.1.1 m.60288 sp MYCBP_HUMAN 67.021 94 31 0 36 129 1 94 4.39E-41 135 MYCBP_HUMAN reviewed C-Myc-binding protein (Associate of Myc 1) (AMY-1) MYCBP AMY1 Homo sapiens (Human) 103 "regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005737; GO:0005739; GO:0006351; GO:0006355; GO:0007283 0 0 0 0 Q9CQ52 CHOYP_CEL3B.1.1 m.30565 sp CEL3B_MOUSE 40.467 257 139 8 2 250 18 268 4.39E-54 179 CEL3B_MOUSE reviewed Chymotrypsin-like elastase family member 3B (EC 3.4.21.70) (Elastase IIIB) (Elastase-3B) (Protease E) Cela3b Ela3 Ela3b Mus musculus (Mouse) 269 cholesterol metabolic process [GO:0008203] GO:0004252; GO:0005615; GO:0008203 0 0 cd00190; PF00089; Q9D1L0 CHOYP_RL39.1.2 m.5372 sp CHCH2_MOUSE 58.333 108 36 4 42 143 48 152 4.39E-33 117 CHCH2_MOUSE reviewed Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 Chchd2 Mus musculus (Mouse) 153 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cellular response to hypoxia [GO:1900037]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005739; GO:0005758; GO:0006351; GO:0008134; GO:0043565; GO:0045944; GO:1900037 0 0 0 0 Q9UUI3 CHOYP_LOC101063699.1.1 m.18944 sp SA145_SCHPO 41.418 536 255 11 573 1089 101 596 4.39E-100 332 SA145_SCHPO reviewed Pre-mRNA-splicing factor sap145 (Spliceosome-associated protein 145) sap145 SPAC22F8.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 601 "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]" GO:0000245; GO:0000398; GO:0003723; GO:0005634; GO:0005684; GO:0005686; GO:0005737; GO:0071011; GO:0071013 0 0 0 PF04037;PF04046; Q9Y6R7 CHOYP_BRAFLDRAFT_66204.3.3 m.29601 sp FCGBP_HUMAN 23.035 369 259 8 36 400 28 375 4.39E-16 84.3 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A2AIW0 CHOYP_BRAFLDRAFT_65137.1.1 m.64534 sp SDCG3_MOUSE 32.258 217 120 6 7 205 221 428 4.40E-18 85.1 SDCG3_MOUSE reviewed Serologically defined colon cancer antigen 3 homolog Sdccag3 Mus musculus (Mouse) 432 "cell cycle [GO:0007049]; cell division [GO:0051301]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0005769; GO:0007049; GO:0015031; GO:0030496; GO:0030904; GO:0032465; GO:0051301; GO:0055037; GO:1990126 0 0 0 0 A2AV25 CHOYP_LOC101161423.1.1 m.63056 sp FBCD1_MOUSE 50.34 147 64 2 15 152 300 446 4.40E-45 156 FBCD1_MOUSE reviewed Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) 459 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; A7S8T5 CHOYP_LOC100377651.1.1 m.66235 sp CCD42_NEMVE 28.322 286 192 5 57 335 33 312 4.40E-21 95.5 CCD42_NEMVE reviewed Coiled-coil domain-containing protein 42 homolog v1g187067 Nematostella vectensis (Starlet sea anemone) 312 0 0 0 0 0 PF13863; C6K2K4 CHOYP_LOC100897429.1.1 m.54307 sp NETO2_RAT 26.014 419 259 16 5 406 13 397 4.40E-20 97.1 NETO2_RAT reviewed Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2) Neto2 Btcl2 Rattus norvegicus (Rat) 525 regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0016021; GO:2000312 0 0 0 PF00431;PF00057; O14981 CHOYP_BTAF1.1.2 m.25872 sp BTAF1_HUMAN 70.286 175 52 0 1 175 1221 1395 4.40E-81 265 BTAF1_HUMAN reviewed TATA-binding protein-associated factor 172 (EC 3.6.4.-) (ATP-dependent helicase BTAF1) (B-TFIID transcription factor-associated 170 kDa subunit) (TAF(II)170) (TBP-associated factor 172) (TAF-172) BTAF1 TAF172 Homo sapiens (Human) 1849 "negative regulation of chromatin binding [GO:0035562]; negative regulation of transcription, DNA-templated [GO:0045892]" GO:0003677; GO:0003700; GO:0004386; GO:0005524; GO:0005654; GO:0035562; GO:0043231; GO:0045892 0 0 0 PF12054;PF00271;PF00176; O70277 CHOYP_BRAFLDRAFT_255103.17.18 m.64746 sp TRIM3_RAT 29.474 95 59 3 154 242 614 706 4.40E-06 50.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P08004 CHOYP_AGAP_AGAP001748.2.2 m.46817 sp CHS1_YEAST 26.593 361 211 12 521 832 617 972 4.40E-19 97.1 CHS1_YEAST reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) CHS1 YNL192W N1404 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1131 cell separation after cytokinesis [GO:0000920]; cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0000920; GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0045009; GO:0071555 0 0 0 PF01644;PF08407; P35658 CHOYP_NUP214.3.3 m.52826 sp NU214_HUMAN 36.341 399 237 10 5 391 11 404 4.40E-80 299 NU214_HUMAN reviewed Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN) NUP214 CAIN CAN KIAA0023 Homo sapiens (Human) 2090 gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein sumoylation [GO:0016925]; regulation of cell cycle [GO:0051726]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of mRNA stability [GO:0043488]; RNA export from nucleus [GO:0006405]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005049; GO:0005634; GO:0005654; GO:0005829; GO:0005925; GO:0006405; GO:0006406; GO:0006409; GO:0006606; GO:0006611; GO:0007077; GO:0008139; GO:0010827; GO:0016032; GO:0016925; GO:0017056; GO:0019083; GO:0031047; GO:0043231; GO:0043488; GO:0051726; GO:0075733; GO:1900034; GO:1990876 0 0 0 0 P48148 CHOYP_LOC101071942.1.1 m.18523 sp RHO1_DROME 78.358 134 26 1 2 135 62 192 4.40E-71 214 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; P53355 CHOYP_LOC100894097.1.1 m.9668 sp DAPK1_HUMAN 35.204 196 118 4 24 216 395 584 4.40E-25 110 DAPK1_HUMAN reviewed Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1) DAPK1 DAPK Homo sapiens (Human) 1430 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to interferon-gamma [GO:0071346]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intracellular signal transduction [GO:0035556]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of translation [GO:0017148]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of autophagy [GO:0010506]; regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310] GO:0004672; GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005525; GO:0005737; GO:0005886; GO:0006468; GO:0006915; GO:0008625; GO:0010506; GO:0015629; GO:0017075; GO:0017148; GO:0035556; GO:0042802; GO:0042981; GO:0043280; GO:0046777; GO:0071346; GO:0097190; GO:1902042; GO:2000310 0 0 0 PF12796;PF00531;PF00069; Q1PS67 CHOYP_TERT.1.2 m.18964 sp TERT_ORYLA 22.446 597 378 19 1 530 10 588 4.40E-27 119 TERT_ORYLA reviewed Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) tert Oryzias latipes (Japanese rice fish) (Japanese killifish) 1090 DNA strand elongation [GO:0022616] GO:0000333; GO:0000781; GO:0003677; GO:0003721; GO:0022616; GO:0046872; GO:0070034 0 0 0 PF00078;PF12009; Q2TA24 CHOYP_BRAFLDRAFT_114064.1.1 m.35157 sp VATO_BOVIN 63.298 188 68 1 31 218 18 204 4.40E-76 231 VATO_BOVIN reviewed V-type proton ATPase 21 kDa proteolipid subunit (V-ATPase 21 kDa proteolipid subunit) (Vacuolar proton pump 21 kDa proteolipid subunit) ATP6V0B Bos taurus (Bovine) 205 ATP hydrolysis coupled proton transport [GO:0015991]; vacuolar acidification [GO:0007035] GO:0000220; GO:0005768; GO:0007035; GO:0015991; GO:0016021; GO:0046961 0 0 0 PF00137; Q5UR67 CHOYP_NEK4.7.8 m.53807 sp RIBX_MIMIV 44.521 146 76 2 415 555 21 166 4.40E-32 124 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q66IB8 CHOYP_NFX1.1.2 m.13489 sp CB076_DANRE 57.025 121 52 0 34 154 6 126 4.40E-49 157 CB076_DANRE reviewed UPF0538 protein C2orf76 homolog zgc:101851 Danio rerio (Zebrafish) (Brachydanio rerio) 126 0 0 0 0 0 PF10209; Q8UVR8 CHOYP_ALK.2.2 m.58778 sp CSF12_TAKRU 29.082 196 121 4 529 724 811 988 4.40E-16 87.4 CSF12_TAKRU reviewed Macrophage colony-stimulating factor 1 receptor 2 (CSF-1-R 2) (EC 2.7.10.1) csf1r2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 1019 cytokine-mediated signaling pathway [GO:0019221]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0005886; GO:0006954; GO:0007169; GO:0016021; GO:0019221; GO:0045087 0 0 0 PF07714; Q96M34 CHOYP_BRAFLDRAFT_120244.1.2 m.29390 sp CC030_HUMAN 51.163 43 21 0 85 127 494 536 4.40E-10 59.7 CC030_HUMAN reviewed Uncharacterized protein C3orf30 C3orf30 Homo sapiens (Human) 536 0 0 0 0 0 0 Q9H8W5 CHOYP_LOC100374819.7.7 m.66323 sp TRI45_HUMAN 22.799 443 257 14 30 418 27 438 4.40E-14 77.4 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9JJT9 CHOYP_PHAX.1.1 m.16252 sp PHAX_MOUSE 28.438 429 231 17 2 411 6 377 4.40E-31 125 PHAX_MOUSE reviewed Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) Phax Rnuxa Mus musculus (Mouse) 385 protein transport [GO:0015031]; snRNA export from nucleus [GO:0006408] GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006408; GO:0015030; GO:0015031; GO:0015643; GO:0043025; GO:0043231 0 0 0 PF10258; Q9U3P2 CHOYP_PGBM.3.3 m.55207 sp SYG2_CAEEL 26.718 131 82 2 50 180 249 365 4.40E-09 60.1 SYG2_CAEEL reviewed Synaptogenesis protein syg-2 (Synaptogenesis abnormal protein 2) syg-2 C26G2.1 Caenorhabditis elegans 1270 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; collateral sprouting [GO:0048668]; protein localization to synapse [GO:0035418]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007155; GO:0007267; GO:0007416; GO:0008039; GO:0030054; GO:0035418; GO:0042803; GO:0045202; GO:0048668; GO:0050808; GO:0050839 0 0 0 PF08205;PF00041;PF07679; Q9UGM3 CHOYP_LOC757057.4.5 m.60123 sp DMBT1_HUMAN 43.766 393 189 9 1 386 496 863 4.40E-82 277 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; D3YXG0 CHOYP_LOC100707926.4.4 m.47120 sp HMCN1_MOUSE 24.819 415 245 20 144 517 2076 2464 4.41E-12 72.8 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; F6ZQ54 CHOYP_NEMVEDRAFT_V1G207086.1.2 m.32627 sp TRI13_XENTR 22.705 207 133 6 39 234 76 266 4.41E-07 55.1 TRI13_XENTR reviewed Tripartite motif containing 13 trim13 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 408 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; O43704 CHOYP_ST1B1.1.4 m.37097 sp ST1B1_HUMAN 33.667 300 170 12 5 290 6 290 4.41E-35 131 ST1B1_HUMAN reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase) SULT1B1 ST1B2 SULT1B2 Homo sapiens (Human) 296 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cellular biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005829; GO:0006576; GO:0006805; GO:0008146; GO:0008202; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0050427; GO:0051923 0 0 0 PF00685; O70277 CHOYP_contig_032868 m.37556 sp TRIM3_RAT 19.531 512 344 17 65 541 115 593 4.41E-09 63.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_BRAFLDRAFT_224574.9.18 m.39824 sp MEGF6_HUMAN 39.556 225 122 9 1 222 813 1026 4.41E-30 120 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P0C6B1 CHOYP_AGAP_AGAP000544.1.2 m.5527 sp S35E1_RAT 37.209 172 95 4 3 173 247 406 4.41E-24 102 S35E1_RAT reviewed Solute carrier family 35 member E1 Slc35e1 Rattus norvegicus (Rat) 409 carbohydrate transmembrane transport [GO:0034219] GO:0016021; GO:0034219 0 0 0 PF03151; P16157 CHOYP_TVAG_123950.17.31 m.39359 sp ANK1_HUMAN 34.296 277 181 1 8 284 220 495 4.41E-46 169 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18241 CHOYP_LOC373275.1.7 m.4776 sp TBB1_BRUPA 77.66 94 13 1 22 107 166 259 4.41E-46 157 TBB1_BRUPA reviewed Tubulin beta-1 chain (Beta-1-tubulin) 0 Brugia pahangi (Filarial nematode worm) 448 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P28750 CHOYP_LOC100377759.14.15 m.63306 sp EXU_DROME 26.705 176 112 4 245 405 31 204 4.41E-08 58.9 EXU_DROME reviewed Maternal protein exuperantia exu CG8994 Drosophila melanogaster (Fruit fly) 532 "anterior/posterior axis specification, embryo [GO:0008595]; bicoid mRNA localization [GO:0045450]; embryonic development via the syncytial blastoderm [GO:0001700]; lateral inhibition [GO:0046331]; mRNA splicing, via spliceosome [GO:0000398]; ovarian nurse cell to oocyte transport [GO:0007300]; pole plasm oskar mRNA localization [GO:0045451]; regulation of pole plasm oskar mRNA localization [GO:0007317]; spermatogenesis [GO:0007283]" GO:0000398; GO:0000932; GO:0001700; GO:0003723; GO:0005737; GO:0007283; GO:0007300; GO:0007317; GO:0008595; GO:0045450; GO:0045451; GO:0046331; GO:0071011 0 0 0 0 P28827 CHOYP_PTPRA.5.22 m.17114 sp PTPRM_HUMAN 34.633 436 263 9 37 459 880 1306 4.41E-69 243 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P30823 CHOYP_LOC100375631.1.1 m.51385 sp CTR1_RAT 32.759 638 368 13 4 615 3 605 4.41E-95 308 CTR1_RAT reviewed High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor) (Ecotropic retrovirus receptor) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) Slc7a1 Atrc1 Rattus norvegicus (Rat) 624 arginine transport [GO:0015809]; basic amino acid transport [GO:0015802]; L-ornithine transmembrane transport [GO:1903352]; regulation of TOR signaling [GO:0032006] GO:0000064; GO:0005886; GO:0005887; GO:0015174; GO:0015181; GO:0015189; GO:0015297; GO:0015802; GO:0015809; GO:0032006; GO:1903352 0 0 0 PF13520;PF13906; P32138 CHOYP_LOC100369482.2.2 m.12627 sp SQASE_ECOLI 51.378 399 191 2 54 451 279 675 4.41E-138 416 SQASE_ECOLI reviewed Sulfoquinovosidase (SQase) (EC 3.2.1.-) yihQ squQ b3878 JW3849 Escherichia coli (strain K12) 678 carbohydrate metabolic process [GO:0005975] GO:0004553; GO:0005975; GO:0030246 PATHWAY: Glycolipid metabolism. {ECO:0000305|PubMed:24463506}. 0 0 PF01055; P34416 CHOYP_NEB.2.2 m.41168 sp LASP1_CAEEL 51.852 81 39 0 32 112 69 149 4.41E-19 84.7 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P86854 CHOYP_LOC100339607.1.1 m.59202 sp PLCL_MYTGA 31.25 112 76 1 19 129 12 123 4.41E-16 73.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q0V9E9 CHOYP_SETD8.2.3 m.21256 sp KMT5A_XENTR 41.304 138 60 5 22 140 201 336 4.41E-21 91.3 KMT5A_XENTR reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (SET domain-containing protein 8) kmt5a setd8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 336 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007067; GO:0018024; GO:0051301 0 0 0 PF00856; Q0V9E9 CHOYP_SETD8.3.3 m.41530 sp KMT5A_XENTR 41.304 138 60 5 22 140 201 336 4.41E-21 91.3 KMT5A_XENTR reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (SET domain-containing protein 8) kmt5a setd8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 336 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007067; GO:0018024; GO:0051301 0 0 0 PF00856; Q0V9E9 CHOYP_TB11.02.2360.1.3 m.32045 sp KMT5A_XENTR 41.304 138 60 5 22 140 201 336 4.41E-21 91.3 KMT5A_XENTR reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (SET domain-containing protein 8) kmt5a setd8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 336 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007067; GO:0018024; GO:0051301 0 0 0 PF00856; Q0V9E9 CHOYP_TB11.02.2360.2.3 m.39185 sp KMT5A_XENTR 41.304 138 60 5 22 140 201 336 4.41E-21 91.3 KMT5A_XENTR reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (SET domain-containing protein 8) kmt5a setd8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 336 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007067; GO:0018024; GO:0051301 0 0 0 PF00856; Q4V9Y1 CHOYP_PHUM_PHUM306700.1.1 m.61046 sp TMUB1_XENTR 29.839 372 189 14 3 364 1 310 4.41E-31 123 TMUB1_XENTR reviewed Transmembrane and ubiquitin-like domain-containing protein 1 tmub1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 312 0 GO:0005634; GO:0005737; GO:0016021 0 0 0 PF00240; Q502L2 CHOYP_LOC100367769.1.2 m.27169 sp PGAM5_DANRE 57.082 233 93 2 49 279 60 287 4.41E-95 285 PGAM5_DANRE reviewed "Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5)" pgam5 si:dkey-69p22.1 zgc:92057 Danio rerio (Zebrafish) (Brachydanio rerio) 289 programmed cell death [GO:0012501] GO:0004721; GO:0005741; GO:0012501; GO:0016021 0 0 cd07067; PF00300; Q502L2 CHOYP_LOC588383.1.1 m.27416 sp PGAM5_DANRE 57.082 233 93 2 49 279 60 287 4.41E-95 285 PGAM5_DANRE reviewed "Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Phosphoglycerate mutase family member 5)" pgam5 si:dkey-69p22.1 zgc:92057 Danio rerio (Zebrafish) (Brachydanio rerio) 289 programmed cell death [GO:0012501] GO:0004721; GO:0005741; GO:0012501; GO:0016021 0 0 cd07067; PF00300; Q5G268 CHOYP_NETR.1.3 m.34496 sp NETR_NOMLE 54.962 131 58 1 29 159 280 409 4.41E-41 149 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q69ZS7 CHOYP_HBS1L.2.2 m.21375 sp HBS1L_MOUSE 40.909 132 62 4 1 130 1 118 4.41E-23 107 HBS1L_MOUSE reviewed HBS1-like protein Hbs1l Hbs1 Kiaa1038 Mus musculus (Mouse) 682 ribosome disassembly [GO:0032790]; translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0006412; GO:0016020; GO:0032790; GO:0070062 0 0 0 PF03143;PF08938; Q6DJ08 CHOYP_LOC100544135.2.2 m.63693 sp S2538_XENTR 52.332 193 91 1 2 193 109 301 4.41E-65 205 S2538_XENTR reviewed Solute carrier family 25 member 38 slc25a38 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 302 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; translation [GO:0006412] GO:0003735; GO:0005215; GO:0005743; GO:0006412; GO:0006783; GO:0016021; GO:0030218 0 0 0 PF00153; Q8CIQ7 CHOYP_DOCK1.1.2 m.11709 sp DOCK3_MOUSE 44.072 447 234 3 71 517 1164 1594 4.41E-109 369 DOCK3_MOUSE reviewed Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) Dock3 Moca Mus musculus (Mouse) 2027 small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005737; GO:0007264 0 0 0 PF06920;PF14429;PF16172;PF07653; Q92982 CHOYP_contig_039993 m.45241 sp NINJ1_HUMAN 39.344 61 37 0 67 127 39 99 4.41E-09 56.2 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q99M85 CHOYP_LOC580246.1.1 m.48824 sp SCRT1_MOUSE 52.727 110 47 3 301 410 223 327 4.41E-31 124 SCRT1_MOUSE reviewed Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (mScrt) Scrt1 Mus musculus (Mouse) 348 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of neuron migration [GO:2001222]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005634; GO:0006351; GO:0046872; GO:2001222 0 0 0 PF00096;PF13912; Q9BZA8 CHOYP_LOC101157079.2.2 m.7067 sp PC11Y_HUMAN 30.716 866 552 16 3 829 34 890 4.41E-103 357 PC11Y_HUMAN reviewed Protocadherin-11 Y-linked (Protocadherin-11) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC) (Protocadherin-22) PCDH11Y PCDH11 PCDH22 PCDHY Homo sapiens (Human) 1340 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q9Y6U7 CHOYP_BRAFLDRAFT_122020.1.1 m.13860 sp RN215_HUMAN 29.121 182 112 6 106 278 68 241 4.41E-14 74.7 RN215_HUMAN reviewed RING finger protein 215 RNF215 Homo sapiens (Human) 377 0 GO:0008270; GO:0016021 0 0 0 PF13639; Q9Z258 CHOYP_ISCW_ISCW002159.1.1 m.765 sp KCNT1_RAT 39.516 124 62 2 2 125 526 636 4.41E-23 100 KCNT1_RAT reviewed Potassium channel subfamily T member 1 (Sequence like a calcium-activated potassium channel subunit) Kcnt1 Slack Rattus norvegicus (Rat) 1237 potassium ion transport [GO:0006813] GO:0005249; GO:0005267; GO:0006813; GO:0008076; GO:0015269; GO:0016021 0 0 0 PF03493;PF07885; D3YXG0 CHOYP_BRAFLDRAFT_236936.2.6 m.17168 sp HMCN1_MOUSE 43.421 228 115 6 25 241 4531 4755 4.42E-46 170 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O46160 CHOYP_RL14.7.9 m.44964 sp RL14_LUMRU 65 140 48 1 3 141 1 140 4.42E-60 186 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O60304 CHOYP_RBAK.1.1 m.13837 sp ZN500_HUMAN 56.79 81 35 0 11 91 377 457 4.42E-23 103 ZN500_HUMAN reviewed Zinc finger protein 500 (Zinc finger protein with KRAB and SCAN domains 18) ZNF500 KIAA0557 ZKSCAN18 Homo sapiens (Human) 480 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0043565; GO:0046872 0 0 cd07765; PF01352;PF02023;PF00096;PF13912; O70277 CHOYP_BRAFLDRAFT_87291.3.4 m.39278 sp TRIM3_RAT 21.951 164 113 3 125 286 593 743 4.42E-06 51.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P0C6T1 CHOYP_CHTF8.1.1 m.19512 sp CTF8_RAT 48.78 123 61 2 4 126 1 121 4.42E-39 130 CTF8_RAT reviewed Chromosome transmission fidelity protein 8 homolog Chtf8 Ctf8 Rattus norvegicus (Rat) 121 DNA replication [GO:0006260]; mitotic sister chromatid cohesion [GO:0007064]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264] GO:0003677; GO:0005634; GO:0006260; GO:0007064; GO:0031390; GO:1900264 0 0 0 PF09696; P35803 CHOYP_GPM6A.1.1 m.41817 sp GPM6B_MOUSE 26.877 253 149 10 54 277 59 304 4.42E-13 71.6 GPM6B_MOUSE reviewed Neuronal membrane glycoprotein M6-b (M6b) Gpm6b M6b Mus musculus (Mouse) 328 extracellular matrix assembly [GO:0085029]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of serotonin uptake [GO:0051612]; ossification [GO:0001503]; positive regulation of bone mineralization [GO:0030501]; protein transport [GO:0015031]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of focal adhesion assembly [GO:0051893] GO:0001503; GO:0005886; GO:0015031; GO:0016021; GO:0030501; GO:0032956; GO:0045121; GO:0051612; GO:0051893; GO:0085029; GO:2000009 0 0 0 PF01275; Q06806 CHOYP_MEG10.50.91 m.46730 sp TIE1_MOUSE 44.828 58 30 1 53 108 291 348 4.42E-07 55.8 TIE1_MOUSE reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) Tie1 Tie Tie-1 Mus musculus (Mouse) 1134 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; in utero embryonic development [GO:0001701]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; response to retinoic acid [GO:0032526]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001701; GO:0004714; GO:0005524; GO:0005886; GO:0016021; GO:0016525; GO:0030336; GO:0032526; GO:0045026 0 0 0 PF00041;PF00047;PF07714; Q1PRL4 CHOYP_BRAFLDRAFT_69052.1.1 m.63043 sp LIN41_CHICK 22.368 152 104 2 8 145 286 437 4.42E-07 52.8 LIN41_CHICK reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) 876 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q2KJG4 CHOYP_LOC584003.1.1 m.10580 sp MGST2_BOVIN 44.203 138 73 2 21 156 7 142 4.42E-34 120 MGST2_BOVIN reviewed Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) MGST2 Bos taurus (Bovine) 146 glutathione biosynthetic process [GO:0006750]; leukotriene biosynthetic process [GO:0019370] GO:0004364; GO:0004464; GO:0004602; GO:0005635; GO:0005783; GO:0005789; GO:0005886; GO:0006750; GO:0008047; GO:0016021; GO:0019370; GO:0031090 0 0 0 PF01124; Q460N3 CHOYP_PAR15.1.6 m.3666 sp PAR15_HUMAN 23.817 655 353 26 2 637 149 676 4.42E-31 132 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q4R632 CHOYP_LOC580601.5.5 m.59671 sp CBPC2_MACFA 48.673 452 214 4 320 771 228 661 4.42E-144 459 CBPC2_MACFA reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) AGBL2 CCP2 QtsA-19251 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 840 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q5UR67 CHOYP_LOC100638431.6.10 m.53973 sp RIBX_MIMIV 39.726 146 83 2 217 357 22 167 4.42E-25 103 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5ZLG9 CHOYP_WDR59.3.5 m.39121 sp WDR59_CHICK 51.923 104 50 0 3 106 865 968 4.42E-41 147 WDR59_CHICK reviewed WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) 973 cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034198; GO:0061700 0 0 0 PF00400; Q6DHK8 CHOYP_NEMVEDRAFT_V1G234329.1.1 m.10019 sp NTCP7_DANRE 54.128 327 148 1 22 348 7 331 4.42E-122 358 NTCP7_DANRE reviewed Sodium/bile acid cotransporter 7 (Na(+)/bile acid cotransporter 7) (Solute carrier family 10 member 7) slc10a7 zgc:92251 Danio rerio (Zebrafish) (Brachydanio rerio) 336 sodium ion transport [GO:0006814] GO:0006814; GO:0015293; GO:0016021 0 0 0 PF13593; Q6NW52 CHOYP_LOC100711559.1.1 m.10313 sp MSRB2_DANRE 70.079 127 38 0 64 190 50 176 4.42E-65 201 MSRB2_DANRE reviewed "Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.-)" msrb2 zgc:85965 Danio rerio (Zebrafish) (Brachydanio rerio) 180 actin filament polymerization [GO:0030041]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] GO:0003779; GO:0005739; GO:0006979; GO:0030041; GO:0030091; GO:0033743; GO:0046872 0 0 0 PF01641; Q6PFY8 CHOYP_LOC100373888.1.9 m.17117 sp TRI45_MOUSE 24.928 345 201 9 16 322 18 342 4.42E-15 82 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7T3S3 CHOYP_CPIPJ_CPIJ004782.1.1 m.11134 sp CHSTB_DANRE 35.922 206 122 4 109 307 108 310 4.42E-35 136 CHSTB_DANRE reviewed Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4ST-1) (C4ST1) (zC4ST-1) chst11 Danio rerio (Zebrafish) (Brachydanio rerio) 352 carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206]; motor neuron axon guidance [GO:0008045]; muscle organ development [GO:0007517] GO:0000139; GO:0007517; GO:0008045; GO:0016021; GO:0016051; GO:0030206; GO:0047756 0 0 0 PF03567; Q8C0J2 CHOYP_BRAFLDRAFT_123636.1.1 m.16162 sp A16L1_MOUSE 44.221 597 272 8 22 561 13 605 4.42E-164 483 A16L1_MOUSE reviewed Autophagy-related protein 16-1 (APG16-like 1) Atg16l1 Apg16l Mus musculus (Mouse) 607 autophagosome assembly [GO:0000045]; macroautophagy [GO:0016236]; negative stranded viral RNA replication [GO:0039689]; protein transport [GO:0015031] GO:0000045; GO:0000421; GO:0005776; GO:0005829; GO:0005930; GO:0015031; GO:0016236; GO:0034045; GO:0039689; GO:0042802 0 0 0 PF08614;PF00400; Q8R555 CHOYP_LOC100716602.1.1 m.17509 sp CRAC1_MOUSE 52.183 504 213 10 53 552 53 532 4.42E-169 497 CRAC1_MOUSE reviewed Cartilage acidic protein 1 (68 kDa chondrocyte-expressed protein) (CEP-68) (ASPIC) (Protein CRTAC1-B) Crtac1 Aspic1 Cep68 Mus musculus (Mouse) 646 axonal fasciculation [GO:0007413]; negative regulation of receptor binding [GO:1900121]; olfactory bulb development [GO:0021772] GO:0005509; GO:0005578; GO:0007413; GO:0021772; GO:0030426; GO:0070062; GO:1900121 0 0 0 PF07645;PF07593; Q9HBU6 CHOYP_LOC578881.1.1 m.9743 sp EKI1_HUMAN 42.735 351 193 4 4 350 103 449 4.42E-99 303 EKI1_HUMAN reviewed Ethanolamine kinase 1 (EKI 1) (EC 2.7.1.82) ETNK1 EKI1 Homo sapiens (Human) 452 phosphatidylethanolamine biosynthetic process [GO:0006646] GO:0004305; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006646; GO:0016020 PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. 0 0 0 O46470 CHOYP_LOC655987.2.3 m.37938 sp RGS7_BOVIN 61.538 351 124 4 34 380 16 359 4.43E-159 458 RGS7_BOVIN reviewed Regulator of G-protein signaling 7 (RGS7) RGS7 Bos taurus (Bovine) 469 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968] GO:0004871; GO:0005096; GO:0005737; GO:0005829; GO:0005834; GO:0005886; GO:0007186; GO:0009968; GO:0035556 0 0 cd00068; PF00610;PF00631;PF00615; O70352 CHOYP_DWIL_GK16746.2.2 m.26518 sp CD82_RAT 27.184 206 133 3 89 282 59 259 4.43E-20 90.5 CD82_RAT reviewed CD82 antigen (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82) Cd82 Kai1 Rattus norvegicus (Rat) 266 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; O73791 CHOYP_MEG10.51.91 m.46753 sp TIE2_DANRE 39.516 124 66 5 186 306 218 335 4.43E-19 91.7 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O88281 CHOYP_LOC100490321.2.2 m.54266 sp MEGF6_RAT 29.345 702 426 29 4 678 764 1422 4.43E-56 212 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P20825 CHOYP_CRE_07402.1.1 m.32222 sp POL2_DROME 33.333 561 333 12 3 555 157 684 4.43E-77 275 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P20965 CHOYP_LOC100370010.3.5 m.19116 sp PABPA_XENLA 70.455 220 64 1 2 221 175 393 4.43E-106 322 PABPA_XENLA reviewed Polyadenylate-binding protein 1-A (PABP-1-A) (Poly(A)-binding protein 1-A) (xPABP1-A) (Cytoplasmic poly(A)-binding protein 1-A) pabpc1-a pabp pabp1 Xenopus laevis (African clawed frog) 633 "gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of translation [GO:0006417]; translation [GO:0006412]" GO:0000166; GO:0005737; GO:0005844; GO:0006397; GO:0006412; GO:0006417; GO:0008143; GO:0031047; GO:0031370; GO:0043621; GO:0048255; GO:0060212; GO:0060213; GO:1900153 0 0 0 PF00658;PF00076; P60522 CHOYP_BRAFLDRAFT_276662.1.1 m.52846 sp GBRL2_RAT 75 116 29 0 1 116 1 116 4.43E-61 185 GBRL2_RAT reviewed Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) Gabarapl2 Gef2 Rattus norvegicus (Rat) 117 autophagosome assembly [GO:0000045]; cellular response to nitrogen starvation [GO:0006995]; mitophagy [GO:0000422]; negative regulation of proteasomal protein catabolic process [GO:1901799]; protein transport [GO:0015031] GO:0000045; GO:0000139; GO:0000421; GO:0000422; GO:0005776; GO:0005829; GO:0006995; GO:0015031; GO:0031410; GO:1901799 0 0 cd01611; PF02991; P86948 CHOYP_MP.2.4 m.7735 sp MP_PINMA 41.718 163 88 1 1 156 1 163 4.43E-25 101 MP_PINMA reviewed Mantle protein (MP) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 260 0 GO:0005576 0 0 0 0 P90689 CHOYP_ACT.27.27 m.66538 sp ACT_BRUMA 76.571 175 28 2 1 175 1 162 4.43E-88 265 ACT_BRUMA reviewed Actin 0 Brugia malayi (Filarial nematode worm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q2PZL6 CHOYP_FAT3.1.3 m.22531 sp FAT4_MOUSE 30.82 610 381 19 109 707 2540 3119 4.43E-56 211 FAT4_MOUSE reviewed Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) Fat4 Fatj Mus musculus (Mouse) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; establishment of planar polarity [GO:0001736]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; kidney development [GO:0001822]; nephron development [GO:0072006]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0001736; GO:0001822; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0007219; GO:0008543; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072006; GO:0072137; GO:0072307 0 0 0 PF00028;PF00008;PF07645;PF12661;PF02210; Q2T9S4 CHOYP_BRAFLDRAFT_128828.1.2 m.7356 sp PGP_BOVIN 33.01 309 177 9 51 339 17 315 4.43E-54 183 PGP_BOVIN reviewed Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP) PGP Bos taurus (Bovine) 321 dephosphorylation [GO:0016311]; glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721]; peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0000121; GO:0000287; GO:0004721; GO:0004725; GO:0005829; GO:0006114; GO:0006650; GO:0008967; GO:0016311; GO:0035335; GO:0043136; GO:0045721; GO:0098519 0 0 0 PF13344; Q56R14 CHOYP_BRAFLDRAFT_68030.1.1 m.41803 sp TRI33_XENLA 25.82 244 167 7 47 283 96 332 4.43E-13 75.5 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5EA86 CHOYP_LOC658973.1.1 m.4689 sp TM183_BOVIN 31.105 344 222 6 31 367 37 372 4.43E-45 162 TM183_BOVIN reviewed Transmembrane protein 183 TMEM183 Bos taurus (Bovine) 376 0 GO:0016021 0 0 0 0 Q5F356 CHOYP_LOC100373656.1.1 m.57144 sp PI42A_CHICK 59.854 411 150 4 2 408 5 404 4.43E-157 451 PI42A_CHICK reviewed Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(5)P-4-kinase isoform 2-alpha) PIP4K2A PIP5K2A RCJMB04_33l24 Gallus gallus (Chicken) 405 0 GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0016309 0 0 0 PF01504; Q5ZIJ9 CHOYP_MIB2.5.6 m.43978 sp MIB2_CHICK 34.941 850 478 15 1 811 1 814 4.43E-163 507 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6AYX5 CHOYP_LOC100366442.2.4 m.6528 sp ODFP2_RAT 39.663 832 419 12 9 771 6 823 4.43E-170 513 ODFP2_RAT reviewed Outer dense fiber protein 2 (84 kDa outer dense fiber protein) (Cenexin) (Outer dense fiber of sperm tails protein 2) Odf2 Odf84 KKT4 Rattus norvegicus (Rat) 825 multicellular organism development [GO:0007275]; regulation of cilium assembly [GO:1902017]; spermatid development [GO:0007286] GO:0000922; GO:0001520; GO:0005634; GO:0005814; GO:0005874; GO:0007275; GO:0007286; GO:0036064; GO:0072372; GO:0097539; GO:1902017 0 0 0 0 Q7Z3B3 CHOYP_LOC100375819.1.1 m.30196 sp KANL1_HUMAN 32.08 851 427 30 244 1040 290 1043 4.43E-80 288 KANL1_HUMAN reviewed KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) KANSL1 CENP-36 KIAA1267 MSL1V1 NSL1 Homo sapiens (Human) 1105 histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982] GO:0000123; GO:0000777; GO:0005634; GO:0005654; GO:0043981; GO:0043982; GO:0043984; GO:0071339 0 0 0 PF15275; Q8K3A0 CHOYP_LOC100878672.1.1 m.34371 sp HSC20_MOUSE 37.569 181 109 3 79 255 40 220 4.43E-34 125 HSC20_MOUSE reviewed "Iron-sulfur cluster co-chaperone protein HscB, mitochondrial (Hsc20)" Hscb Hsc20 Mus musculus (Mouse) 234 iron-sulfur cluster assembly [GO:0016226]; protein folding [GO:0006457]; protein oligomerization [GO:0051259] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0016226; GO:0046872; GO:0051087; GO:0051259 PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. 0 cd06257; PF07743; Q8TBZ5 CHOYP_RL17.2.7 m.34420 sp ZN502_HUMAN 50.216 231 114 1 196 426 237 466 4.43E-70 240 ZN502_HUMAN reviewed Zinc finger protein 502 ZNF502 Homo sapiens (Human) 544 "positive regulation by host of viral process [GO:0044794]; positive regulation by host of viral release from host cell [GO:0044791]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0005634; GO:0006351; GO:0006355; GO:0044791; GO:0044794; GO:0046872 0 0 0 PF00096;PF13912; Q96MS3 CHOYP_GL1D1.3.3 m.57118 sp GL1D1_HUMAN 35.78 109 67 2 5 112 3 109 4.43E-13 67 GL1D1_HUMAN reviewed Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) GLT1D1 Homo sapiens (Human) 346 0 GO:0005576; GO:0005737; GO:0016757 0 0 0 PF00534; Q9VCA8 CHOYP_LOC100641729.1.10 m.3248 sp ANKHM_DROME 33.75 320 176 10 66 352 622 938 4.43E-34 136 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9Z139 CHOYP_LOC100533220.1.2 m.6033 sp ROR1_MOUSE 39.437 71 43 0 67 137 58 128 4.43E-13 68.2 ROR1_MOUSE reviewed "Inactive tyrosine-protein kinase transmembrane receptor ROR1 (mROR1) (Neurotrophic tyrosine kinase, receptor-related 1)" Ror1 Ntrkr1 Mus musculus (Mouse) 937 transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; Wnt signaling pathway [GO:0016055] GO:0004714; GO:0005524; GO:0005887; GO:0007169; GO:0016055; GO:0017147; GO:0043235 0 0 0 PF01392;PF07679;PF00051;PF07714; E1C3U7 CHOYP_ISCW_ISCW021371.1.1 m.23570 sp LOXL2_CHICK 29.464 112 74 3 145 252 49 159 4.44E-07 56.2 LOXL2_CHICK reviewed Lysyl oxidase homolog 2 (EC 1.4.3.13) (Lysyl oxidase-like protein 2) LOXL2 Gallus gallus (Chicken) 774 "collagen fibril organization [GO:0030199]; covalent chromatin modification [GO:0016569]; endothelial cell migration [GO:0043542]; endothelial cell proliferation [GO:0001935]; epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of chondrocyte differentiation [GO:0032332]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; transcription, DNA-templated [GO:0006351]" GO:0001666; GO:0001837; GO:0001935; GO:0002040; GO:0004720; GO:0005044; GO:0005507; GO:0005604; GO:0005634; GO:0005694; GO:0006351; GO:0016020; GO:0016569; GO:0030199; GO:0032332; GO:0043542; GO:0045892 0 0 0 PF01186;PF00530; O00370 CHOYP_LOC100562878.1.2 m.31568 sp LORF2_HUMAN 28.417 278 194 3 1 275 599 874 4.44E-32 130 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O15027 CHOYP_SEC16A.1.1 m.36800 sp SC16A_HUMAN 50.905 497 213 10 973 1448 1227 1713 4.44E-148 512 SC16A_HUMAN reviewed Protein transport protein Sec16A (SEC16 homolog A) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) 2179 COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031]; substantia nigra development [GO:0021762] GO:0000139; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0007029; GO:0015031; GO:0021762; GO:0048208 0 0 0 PF12932;PF12931; O54960 CHOYP_CAPON.1.1 m.1965 sp CAPON_RAT 45.06 415 168 10 1 359 1 411 4.44E-74 250 CAPON_RAT reviewed Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) Nos1ap Capon Rattus norvegicus (Rat) 503 negative regulation of neuron death [GO:1901215]; neuron projection regeneration [GO:0031102]; neurotransmitter secretion [GO:0007269]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; regulation of apoptotic process [GO:0042981]; regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514]; regulation of cardiac muscle cell action potential [GO:0098901]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of nitric-oxide synthase activity [GO:0050999] GO:0002020; GO:0005634; GO:0005737; GO:0005829; GO:0007269; GO:0030165; GO:0031102; GO:0042981; GO:0045428; GO:0050998; GO:0050999; GO:0098793; GO:0098901; GO:1901215; GO:1901841; GO:1902514; GO:2000170 0 0 0 PF00640; O70277 CHOYP_TRIM2.57.59 m.64467 sp TRIM3_RAT 30.769 117 72 4 66 174 579 694 4.44E-07 52.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P07589 CHOYP_LOC577931.3.3 m.35020 sp FINC_BOVIN 22.813 583 340 17 1493 2065 1586 2068 4.44E-13 80.1 FINC_BOVIN reviewed Fibronectin (FN) [Cleaved into: Anastellin] FN1 Bos taurus (Bovine) 2478 acute-phase response [GO:0006953]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; regulation of cell shape [GO:0008360] GO:0001525; GO:0005576; GO:0005578; GO:0006953; GO:0007155; GO:0008201; GO:0008360 0 0 cd00062; PF00039;PF00040;PF00041; P18433 CHOYP_PTPRA.14.22 m.52057 sp PTPRA_HUMAN 29.972 704 439 23 440 1116 124 800 4.44E-80 283 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P22105 CHOYP_DP.1.1 m.49874 sp TENX_HUMAN 33.562 146 74 10 170 314 208 331 4.44E-11 67.4 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; Q03168 CHOYP_MGC89016.1.2 m.76 sp ASPP_AEDAE 59.794 388 150 4 39 426 3 384 4.44E-171 487 ASPP_AEDAE reviewed Lysosomal aspartic protease (EC 3.4.23.-) AAEL006169 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 387 0 GO:0004190; GO:0005764 0 0 0 PF00026; Q1EG27 CHOYP_MYO16.3.4 m.55419 sp MYO3B_MOUSE 38.903 766 422 13 193 937 334 1074 4.44E-171 558 MYO3B_MOUSE reviewed Myosin-IIIb (EC 2.7.11.1) Myo3b Mus musculus (Mouse) 1305 peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of filopodium assembly [GO:0051491]; protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0000146; GO:0001750; GO:0001917; GO:0004674; GO:0005524; GO:0005737; GO:0007601; GO:0016459; GO:0018105; GO:0018107; GO:0032426; GO:0032433; GO:0046777; GO:0050896; GO:0051491 0 0 0 PF00612;PF00063;PF00069; Q1L987 CHOYP_PLK1.1.2 m.26372 sp ATPF1_DANRE 34.94 249 141 3 75 314 51 287 4.44E-50 172 ATPF1_DANRE reviewed ATP synthase mitochondrial F1 complex assembly factor 1 atpaf1 si:dkey-171o17.2 zgc:110583 Danio rerio (Zebrafish) (Brachydanio rerio) 302 mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615] GO:0005739; GO:0033615 0 0 0 PF06644; Q567Z6 CHOYP_LOC100368616.1.1 m.51357 sp CRIPT_DANRE 82.178 101 16 1 22 120 1 101 4.44E-56 172 CRIPT_DANRE reviewed Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3) cript zgc:110618 Danio rerio (Zebrafish) (Brachydanio rerio) 101 0 GO:0005737 0 0 0 PF10235; Q5UNS9 CHOYP_HMCN2.3.12 m.26811 sp COLL7_MIMIV 50 172 80 2 139 304 295 466 4.44E-29 128 COLL7_MIMIV reviewed Collagen-like protein 7 MIMI_L669 Acanthamoeba polyphaga mimivirus (APMV) 1937 0 GO:0019012 0 0 0 PF01391; Q66HA4 CHOYP_LOC100468642.1.1 m.2009 sp TAXB1_RAT 26.123 957 474 27 18 896 4 805 4.44E-67 243 TAXB1_RAT reviewed Tax1-binding protein 1 homolog (Liver regeneration-related protein LRRG004) Tax1bp1 Aa1076 Rattus norvegicus (Rat) 813 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of NF-kappaB transcription factor activity [GO:0032088] GO:0006915; GO:0032088; GO:0043066; GO:0046872; GO:0070062 0 0 0 PF07888; Q6PFY8 CHOYP_LOC100375954.4.6 m.32949 sp TRI45_MOUSE 28.986 207 119 7 5 195 127 321 4.44E-12 72 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6ZNB7 CHOYP_BRAFLDRAFT_214818.1.1 m.18495 sp ALKMO_HUMAN 54.568 405 181 2 20 422 2 405 4.44E-159 459 ALKMO_HUMAN reviewed Alkylglycerol monooxygenase (EC 1.14.16.5) (Transmembrane protein 195) AGMO TMEM195 Homo sapiens (Human) 445 ether lipid metabolic process [GO:0046485]; fatty acid biosynthetic process [GO:0006633]; membrane lipid metabolic process [GO:0006643]; triglyceride biosynthetic process [GO:0019432] GO:0005506; GO:0005783; GO:0005789; GO:0006633; GO:0006643; GO:0016021; GO:0019432; GO:0046485; GO:0050479 0 0 0 PF04116; Q7ZYH1 CHOYP_SIN1.1.1 m.1534 sp SIN1_XENLA 49.614 518 245 10 1 507 1 513 4.44E-164 478 SIN1_XENLA reviewed Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) mapkap1 sin1 Xenopus laevis (African clawed frog) 520 0 GO:0031932 0 0 0 PF16978;PF05422;PF16979; Q801G1 CHOYP_ARH.2.2 m.25884 sp ARHA_XENLA 47.904 167 78 2 6 168 9 170 4.44E-49 168 ARHA_XENLA reviewed Low density lipoprotein receptor adapter protein 1-A (Autosomal recessive hypercholesterolemia protein homolog alpha) (ARH alpha) (xARH alpha) (Phosphotyrosine-binding protein) (Xcat4) ldlrap1-a Xenopus laevis (African clawed frog) 309 cholesterol metabolic process [GO:0008203]; endocytosis [GO:0006897] GO:0005737; GO:0006897; GO:0008203 0 0 0 PF00640; Q8AVY1 CHOYP_LOC100207216.1.2 m.22252 sp ODF3A_XENLA 64.356 101 36 0 10 110 156 256 4.44E-38 131 ODF3A_XENLA reviewed Outer dense fiber protein 3 (Outer dense fiber of sperm tails protein 3) odf3 Xenopus laevis (African clawed frog) 256 0 GO:0005737 0 0 0 PF07004; Q8VDT1 CHOYP_BRAFLDRAFT_282752.2.2 m.17526 sp SC5A9_MOUSE 44.257 296 154 3 10 296 341 634 4.44E-86 274 SC5A9_MOUSE reviewed Sodium/glucose cotransporter 4 (Na(+)/glucose cotransporter 4) (mSGLT4) (Solute carrier family 5 member 9) Slc5a9 Sglt4 Mus musculus (Mouse) 685 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015293; GO:0070062 0 0 0 PF00474; Q91ZW6 CHOYP_LOC100024134.1.1 m.61877 sp TMLH_RAT 39.901 203 120 2 92 293 56 257 4.44E-50 176 TMLH_RAT reviewed "Trimethyllysine dioxygenase, mitochondrial (EC 1.14.11.8) (Epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (TML hydroxylase) (TML-alpha-ketoglutarate dioxygenase) (TML dioxygenase) (TMLD)" Tmlhe Tmlh Rattus norvegicus (Rat) 421 carnitine biosynthetic process [GO:0045329]; negative regulation of oxidoreductase activity [GO:0051354] GO:0005506; GO:0005739; GO:0005759; GO:0016702; GO:0031418; GO:0045329; GO:0050353; GO:0051354 PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis. 0 0 PF06155;PF02668; Q96LR7 CHOYP_contig_042913 m.49519 sp CB050_HUMAN 32.71 107 72 0 43 149 53 159 4.44E-17 76.3 CB050_HUMAN reviewed Uncharacterized protein C2orf50 C2orf50 Homo sapiens (Human) 162 0 0 0 0 0 0 Q9ESN6 CHOYP_TRIM3.57.58 m.65179 sp TRIM2_MOUSE 28.111 217 130 8 22 226 535 737 4.44E-14 74.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9P215 CHOYP_LOC101169293.3.4 m.17780 sp POGK_HUMAN 39.063 128 74 3 457 581 197 323 4.44E-17 88.6 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9R1C6 CHOYP_ISCW_ISCW016328.1.1 m.10256 sp DGKE_MOUSE 44.569 534 269 12 2 518 17 540 4.44E-151 446 DGKE_MOUSE reviewed Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) Dgke Mus musculus (Mouse) 564 intracellular signal transduction [GO:0035556]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205] GO:0004143; GO:0005524; GO:0005737; GO:0007205; GO:0016020; GO:0016021; GO:0035556; GO:0046872 0 0 0 PF00130;PF00609;PF00781; Q9R1R2 CHOYP_BRAFLDRAFT_87273.2.3 m.32544 sp TRIM3_MOUSE 25 152 109 3 43 190 593 743 4.44E-08 55.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y4A0 CHOYP_LOC100561785.1.1 m.10323 sp JERKL_HUMAN 30.46 174 109 5 141 306 169 338 4.44E-13 75.1 JERKL_HUMAN reviewed Jerky protein homolog-like (Human homolog of mouse jerky gene protein) (HHMJG) JRKL Homo sapiens (Human) 524 central nervous system development [GO:0007417] GO:0003677; GO:0005634; GO:0007417 0 0 0 PF04218;PF03184;PF03221; O35115 CHOYP_SMP_048560.2.2 m.61977 sp FHL2_RAT 54.491 167 76 0 1 167 112 278 4.45E-67 208 FHL2_RAT reviewed Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) Fhl2 Dral Slim3 Rattus norvegicus (Rat) 279 "atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; transcription, DNA-templated [GO:0006351]; ventricular cardiac muscle cell development [GO:0055015]" GO:0000122; GO:0001649; GO:0005634; GO:0005925; GO:0006351; GO:0008134; GO:0008270; GO:0009725; GO:0015629; GO:0030018; GO:0031430; GO:0043066; GO:0055014; GO:0055015; GO:0060347 0 0 0 PF00412; O75208 CHOYP_LOC100376454.2.2 m.53666 sp COQ9_HUMAN 44.737 114 63 0 1 114 204 317 4.45E-31 114 COQ9_HUMAN reviewed "Ubiquinone biosynthesis protein COQ9, mitochondrial" COQ9 C16orf49 HSPC326 PSEC0129 Homo sapiens (Human) 318 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; ubiquinone biosynthetic process [GO:0006744]" GO:0005739; GO:0005743; GO:0006120; GO:0006744; GO:0008289; GO:0042803 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000250|UniProtKB:Q8K1Z0}. 0 0 PF08511; O95905 CHOYP_ECD.1.1 m.61798 sp ECD_HUMAN 39.394 495 277 8 11 495 160 641 4.45E-112 350 ECD_HUMAN reviewed Protein ecdysoneless homolog (Human suppressor of GCR two) (hSGT1) ECD Homo sapiens (Human) 644 cell proliferation [GO:0008283]; mRNA processing [GO:0006397]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of glycolytic process [GO:0006110]; RNA splicing [GO:0008380]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0006110; GO:0006366; GO:0006397; GO:0008283; GO:0008380; GO:0035035; GO:0045944; GO:2000045 0 0 0 PF07093; P28828 CHOYP_LOC100633689.1.1 m.63587 sp PTPRM_MOUSE 41.951 205 102 7 1 203 985 1174 4.45E-34 140 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; Q08BD8 CHOYP_NEMVEDRAFT_V1G237042.1.2 m.9307 sp MTRF2_DANRE 37.975 79 44 2 1 77 249 324 4.45E-07 49.7 MTRF2_DANRE reviewed Mitochondrial fission regulator 2 mtfr2 fam54a zgc:153910 Danio rerio (Zebrafish) (Brachydanio rerio) 336 aerobic respiration [GO:0009060]; mitochondrial fission [GO:0000266] GO:0000266; GO:0005739; GO:0009060 0 0 0 PF05308; Q0VD32 CHOYP_CREBL2.1.1 m.33877 sp CRBL2_BOVIN 57.746 71 29 1 16 85 15 85 4.45E-20 87.8 CRBL2_BOVIN reviewed cAMP-responsive element-binding protein-like 2 CREBL2 Bos taurus (Bovine) 120 "cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription, DNA-templated [GO:0045893]; protein stabilization [GO:0050821]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0003700; GO:0005634; GO:0006351; GO:0016032; GO:0016604; GO:0030154; GO:0033138; GO:0043565; GO:0045600; GO:0045893; GO:0046326; GO:0046889; GO:0050821 0 0 0 PF07716; Q5M9B1 CHOYP_BRAFLDRAFT_118668.2.3 m.23701 sp SPSB3_XENLA 36.62 213 128 4 60 271 105 311 4.45E-38 140 SPSB3_XENLA reviewed SPRY domain-containing SOCS box protein 3 (SSB-3) spsb3 Xenopus laevis (African clawed frog) 360 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07525;PF00622; Q5NVB9 CHOYP_Y381.1.4 m.11094 sp ZDH13_PONAB 30.061 163 103 4 104 263 105 259 4.45E-13 73.9 ZDH13_PONAB reviewed Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) ZDHHC13 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 622 0 GO:0000139; GO:0005794; GO:0008270; GO:0015095; GO:0016021; GO:0016409; GO:0019706; GO:0030659; GO:0030660 0 0 0 PF12796;PF01529; Q6P8U6 CHOYP_BRAFLDRAFT_126555.6.6 m.54234 sp LIPP_MOUSE 39.583 432 235 11 28 445 1 420 4.45E-83 268 LIPP_MOUSE reviewed Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) Pnlip Mus musculus (Mouse) 465 intestinal cholesterol absorption [GO:0030299]; lipid catabolic process [GO:0016042]; positive regulation of triglyceride lipase activity [GO:0061365] GO:0004806; GO:0005576; GO:0016042; GO:0030299; GO:0046872; GO:0061365 0 0 0 PF00151;PF01477; Q6QLW4 CHOYP_CYC.5.5 m.63475 sp CYC_PECGU 84.404 109 17 0 1 109 1 109 4.45E-65 194 CYC_PECGU reviewed Cytochrome c 0 Pectinaria gouldii (Trumpet worm) (Ice-cream cone worm) 109 oxidation-reduction process [GO:0055114] GO:0005758; GO:0009055; GO:0020037; GO:0046872; GO:0055114; GO:0070469 0 0 0 PF00034; Q865F7 CHOYP_FABPH.1.1 m.62601 sp FABPH_MYOLU 32.353 136 87 2 8 143 3 133 4.45E-14 67.8 FABPH_MYOLU reviewed "Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP)" FABP3 Myotis lucifugus (Little brown bat) 133 hibernation [GO:0042750] GO:0005215; GO:0005737; GO:0008289; GO:0042750 0 0 0 PF00061; Q8C811 CHOYP_LOC656018.1.1 m.9171 sp S35E2_MOUSE 54.808 312 136 1 39 345 68 379 4.45E-115 343 S35E2_MOUSE reviewed Solute carrier family 35 member E2 Slc35e2 Mus musculus (Mouse) 405 0 GO:0016021 0 0 0 PF03151; Q8VCC1 CHOYP_PGDH.1.5 m.1881 sp PGDH_MOUSE 40.078 257 134 4 5 244 3 256 4.45E-59 191 PGDH_MOUSE reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) Hpgd Pgdh1 Mus musculus (Mouse) 269 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005654; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070062; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q90744 CHOYP_LOC587840.1.1 m.10143 sp NAGAB_CHICK 52.742 383 177 3 17 397 1 381 4.45E-149 431 NAGAB_CHICK reviewed Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Gallus gallus (Chicken) 405 carbohydrate metabolic process [GO:0005975]; glycoside catabolic process [GO:0016139] GO:0004557; GO:0005737; GO:0005764; GO:0005975; GO:0008456; GO:0016139 0 0 cd14792; PF16499; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.5.15 m.25445 sp SACS_MOUSE 32.231 121 72 3 4 115 2112 2231 4.45E-08 57 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9SS90 CHOYP_NEMVEDRAFT_V1G239331.1.2 m.49070 sp RGLG1_ARATH 51.02 49 24 0 63 111 128 176 4.45E-10 58.5 RGLG1_ARATH reviewed E3 ubiquitin-protein ligase RGLG1 (EC 6.3.2.-) (RING domain ligase 1) RGLG1 At3g01650 F4P13.19 Arabidopsis thaliana (Mouse-ear cress) 489 negative regulation of response to water deprivation [GO:0080148] GO:0004842; GO:0005886; GO:0008270; GO:0016874; GO:0080148 0 0 0 PF07002; Q9SS90 CHOYP_NEMVEDRAFT_V1G239331.2.2 m.50530 sp RGLG1_ARATH 51.02 49 24 0 63 111 128 176 4.45E-10 58.5 RGLG1_ARATH reviewed E3 ubiquitin-protein ligase RGLG1 (EC 6.3.2.-) (RING domain ligase 1) RGLG1 At3g01650 F4P13.19 Arabidopsis thaliana (Mouse-ear cress) 489 negative regulation of response to water deprivation [GO:0080148] GO:0004842; GO:0005886; GO:0008270; GO:0016874; GO:0080148 0 0 0 PF07002; Q9Y6C2 CHOYP_LOC100692936.1.1 m.46728 sp EMIL1_HUMAN 31.469 143 76 5 262 387 870 1007 4.45E-10 65.1 EMIL1_HUMAN reviewed EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1) EMILIN1 EMI Homo sapiens (Human) 1016 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0031012; GO:0042802; GO:0070062 0 0 0 PF00386;PF01391;PF07546; A4IF63 CHOYP_LOC100718148.1.1 m.62922 sp TRIM2_BOVIN 29.248 359 233 8 26 367 388 742 4.46E-37 145 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5ED84 CHOYP_LOC100698240.4.4 m.18889 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 4.46E-11 69.7 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O17482 CHOYP_LOC587080.1.1 m.6103 sp TIM_DROVI 40.26 77 46 0 26 102 1017 1093 4.46E-11 63.5 TIM_DROVI reviewed Protein timeless tim Drosophila virilis (Fruit fly) 1343 rhythmic process [GO:0048511] GO:0005634; GO:0048471; GO:0048511 0 0 0 PF04821; P20273 CHOYP_CEAM1.1.1 m.41444 sp CD22_HUMAN 34.615 104 65 3 286 386 234 337 4.46E-07 55.8 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P30622 CHOYP_CLIP1.1.2 m.2342 sp CLIP1_HUMAN 32.483 1059 553 28 1 974 1 982 4.46E-113 391 CLIP1_HUMAN reviewed CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) CLIP1 CYLN1 RSN Homo sapiens (Human) 1438 microtubule bundle formation [GO:0001578]; mitotic nuclear division [GO:0007067]; positive regulation of microtubule polymerization [GO:0031116]; protein transport into plasma membrane raft [GO:0044861]; sister chromatid cohesion [GO:0007062] GO:0000776; GO:0001578; GO:0001726; GO:0005737; GO:0005768; GO:0005813; GO:0005829; GO:0005874; GO:0005881; GO:0005882; GO:0007062; GO:0007067; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0030659; GO:0031116; GO:0035371; GO:0042803; GO:0044861; GO:0046872; GO:0051010; GO:1990752 0 0 0 PF01302;PF16641; P98092 CHOYP_LOC100329098.1.1 m.17756 sp HMCT_BOMMO 25.143 175 107 7 61 219 606 772 4.46E-07 55.1 HMCT_BOMMO reviewed Hemocytin (Humoral lectin) 0 Bombyx mori (Silk moth) 3133 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF08742;PF00754;PF01826;PF00094; Q01196 CHOYP_RUNX1.1.1 m.49526 sp RUNX1_HUMAN 62.5 168 45 3 16 167 21 186 4.46E-61 211 RUNX1_HUMAN reviewed Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) RUNX1 AML1 CBFA2 Homo sapiens (Human) 453 "chondrocyte differentiation [GO:0002062]; hematopoietic stem cell proliferation [GO:0071425]; hemopoiesis [GO:0030097]; myeloid cell differentiation [GO:0030099]; negative regulation of granulocyte differentiation [GO:0030853]; ossification [GO:0001503]; peripheral nervous system neuron development [GO:0048935]; positive regulation of angiogenesis [GO:0045766]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000975; GO:0000977; GO:0001047; GO:0001228; GO:0001503; GO:0002062; GO:0003677; GO:0003700; GO:0005509; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0008134; GO:0030097; GO:0030099; GO:0030853; GO:0030854; GO:0032743; GO:0042803; GO:0043231; GO:0045766; GO:0045893; GO:0045944; GO:0046982; GO:0048935; GO:0071425 0 0 0 PF00853;PF08504; Q0V8T5 CHOYP_BRAFLDRAFT_118602.3.5 m.19625 sp CTP5B_RAT 42.529 87 47 2 4 87 88 174 4.46E-12 70.5 CTP5B_RAT reviewed Contactin-associated protein like 5-2 (Cell recognition molecule Caspr5-2) (Cell recognition molecule Caspr5b) (Contactin-associated protein-like 5b) Cntnap5b Caspr5-2 Rattus norvegicus (Rat) 1292 cell adhesion [GO:0007155] GO:0005509; GO:0007155; GO:0016021 0 0 0 PF00008;PF00754;PF02210; Q13426 CHOYP_LOC100366536.1.3 m.14751 sp XRCC4_HUMAN 23.529 323 214 7 67 376 17 319 4.46E-16 82.8 XRCC4_HUMAN reviewed DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4) XRCC4 Homo sapiens (Human) 336 cellular response to lithium ion [GO:0071285]; DNA ligation involved in DNA repair [GO:0051103]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; positive regulation of ligase activity [GO:0051351]; protein sumoylation [GO:0016925]; response to X-ray [GO:0010165] GO:0005634; GO:0005654; GO:0005813; GO:0005829; GO:0005958; GO:0006302; GO:0006303; GO:0006310; GO:0008022; GO:0010165; GO:0016925; GO:0030054; GO:0032807; GO:0051103; GO:0051351; GO:0070419; GO:0071285; GO:0075713 0 0 0 PF06632; Q496Z9 CHOYP_TRM1L.1.1 m.6966 sp TRM1L_RAT 35.076 459 251 11 26 449 236 682 4.46E-68 233 TRM1L_RAT reviewed TRMT1-like protein (EC 2.1.1.-) Trmt1l Rattus norvegicus (Rat) 723 behavior [GO:0007610]; tRNA processing [GO:0008033] GO:0000049; GO:0007610; GO:0008033; GO:0008168; GO:0044822; GO:0046872 0 0 0 PF02005; Q4KMP7 CHOYP_BRAFLDRAFT_84319.1.1 m.57334 sp TB10B_HUMAN 57.313 335 141 2 41 374 294 627 4.46E-150 446 TB10B_HUMAN reviewed TBC1 domain family member 10B (Rab27A-GAP-beta) TBC1D10B FP2461 Homo sapiens (Human) 808 "activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of GTPase activity [GO:0043087]; regulation of vesicle fusion [GO:0031338]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0005096; GO:0005829; GO:0005886; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0042147; GO:0043087; GO:0090630 0 0 0 PF00566; Q4R7V3 CHOYP_LOC100377771.1.1 m.7044 sp FR1OP_MACFA 57.377 122 49 1 4 122 11 132 4.46E-34 134 FR1OP_MACFA reviewed FGFR1 oncogene partner FGFR1OP QtsA-14293 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 379 microtubule anchoring [GO:0034453] GO:0005737; GO:0005815; GO:0034453 0 0 0 PF09398; Q5ND28 CHOYP_MEG10.3.91 m.2050 sp SREC_MOUSE 35.115 131 79 4 1 131 269 393 4.46E-10 63.5 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q62925 CHOYP_MAP3K1.1.1 m.18218 sp M3K1_RAT 57.766 367 148 4 443 806 1127 1489 4.46E-125 412 M3K1_RAT reviewed Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) Map3k1 Mekk Mekk1 Rattus norvegicus (Rat) 1493 activation of JNKK activity [GO:0007256]; activation of MAPKK activity [GO:0000186]; MAPK cascade [GO:0000165]; negative regulation of actin filament bundle assembly [GO:0032232]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to osmotic stress [GO:0006970] GO:0000165; GO:0000186; GO:0000209; GO:0004706; GO:0004709; GO:0004842; GO:0005524; GO:0005737; GO:0006468; GO:0006970; GO:0007256; GO:0008270; GO:0008432; GO:0016020; GO:0018105; GO:0031434; GO:0032232; GO:0042787; GO:0043065; GO:0043406; GO:0043507; GO:0045944; GO:0046625; GO:0046777; GO:0050434; GO:0051019; GO:0051259 0 0 0 PF00069; Q7TS72 CHOYP_ISCW_ISCW015457.1.1 m.6057 sp IP3KC_MOUSE 41.627 209 114 2 51 255 406 610 4.46E-46 166 IP3KC_MOUSE reviewed "Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C)" Itpkc Mus musculus (Mouse) 678 mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005524; GO:0005654; GO:0005737; GO:0008440; GO:0098779; GO:0098792 0 0 0 PF03770; Q8C7M3 CHOYP_LOC100878853.1.1 m.37994 sp TRIM9_MOUSE 23.837 172 109 5 13 162 166 337 4.46E-07 52.4 TRIM9_MOUSE reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) Trim9 Kiaa0282 Mus musculus (Mouse) 817 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; synaptic vesicle exocytosis [GO:0016079] GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016079; GO:0016874; GO:0030054; GO:0030425; GO:0042803; GO:0043161 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643; Q8N2E2 CHOYP_LOC101068378.3.3 m.29759 sp VWDE_HUMAN 28.793 646 397 27 3 611 7 626 4.46E-58 222 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q95230 CHOYP_LOC100373522.5.5 m.54028 sp SP17_PAPHA 43.396 159 73 4 1 149 1 152 4.46E-31 120 SP17_PAPHA reviewed Sperm surface protein Sp17 (Sperm autoantigenic protein 17) SPA17 SP17 Papio hamadryas (Hamadryas baboon) 163 binding of sperm to zona pellucida [GO:0007339] GO:0007339; GO:0016020 0 0 0 PF00612;PF02197; Q99M80 CHOYP_PTPRC.14.14 m.62306 sp PTPRT_MOUSE 27.243 301 196 7 1 280 1132 1430 4.46E-17 84.7 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_TRIM2.58.59 m.64740 sp TRIM2_MOUSE 26.255 259 168 13 56 301 484 732 4.46E-10 63.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NZN5 CHOYP_LOC100644321.1.7 m.712 sp ARHGC_HUMAN 43.702 389 201 8 643 1016 755 1140 4.46E-80 295 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q9UGU5 CHOYP_HMGXB4.2.2 m.28346 sp HMGX4_HUMAN 43.243 222 99 4 573 794 407 601 4.46E-47 180 HMGX4_HUMAN reviewed HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG) HMGXB4 HMG2L1 HMGBCG Homo sapiens (Human) 601 endosome to lysosome transport [GO:0008333]; negative regulation of Wnt signaling pathway [GO:0030178]; Wnt signaling pathway [GO:0016055] GO:0003677; GO:0008333; GO:0016055; GO:0016589; GO:0030178 0 0 0 PF13775;PF00505; A1BQQ5 CHOYP_LOC575786.2.2 m.58126 sp MR30_CONMR 38.298 141 77 5 4 139 154 289 4.47E-20 87.4 MR30_CONMR reviewed Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp isoform 1/2/3) (Mr30-1/2) 0 Conus marmoreus (Marble cone) 289 0 GO:0005576 0 0 0 PF00188; F8WLE0 CHOYP_LOC100182352.1.2 m.43389 sp KIF28_RAT 32.904 699 393 23 8 659 15 684 4.47E-83 291 KIF28_RAT reviewed Kinesin-like protein KIF28P (Kinesin-like protein 6) Kif28p Klp6 Rattus norvegicus (Rat) 1034 mitochondrion organization [GO:0007005]; organelle transport along microtubule [GO:0072384] GO:0003777; GO:0005524; GO:0005622; GO:0005871; GO:0007005; GO:0016887; GO:0031966; GO:0072384 0 0 0 PF00498;PF12423;PF00225; O18638 CHOYP_LOC100367385.1.1 m.62385 sp OAF_DROVI 43.701 254 132 2 23 267 54 305 4.47E-78 241 OAF_DROVI reviewed Out at first protein oaf Drosophila virilis (Fruit fly) 305 multicellular organism development [GO:0007275] GO:0007275 0 0 0 PF14941; O54983 CHOYP_CRYM.1.1 m.8544 sp CRYM_MOUSE 56.187 299 123 4 5 295 7 305 4.47E-110 324 CRYM_MOUSE reviewed Ketimine reductase mu-crystallin (EC 1.5.1.25) (NADP-regulated thyroid-hormone-binding protein) Crym Mus musculus (Mouse) 313 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; sensory perception of sound [GO:0007605]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327] GO:0000122; GO:0003714; GO:0005634; GO:0005737; GO:0005739; GO:0007605; GO:0042403; GO:0042562; GO:0042803; GO:0047127; GO:0050661; GO:0070062; GO:0070324; GO:0070327 0 0 0 PF02423; P08548 CHOYP_LIN1.2.3 m.35958 sp LIN1_NYCCO 30.128 156 97 2 400 545 436 589 4.47E-13 75.9 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P0CT40 CHOYP_CRE_30767.1.2 m.51494 sp TF29_SCHPO 24.835 455 290 17 1 443 420 834 4.47E-17 89 TF29_SCHPO reviewed Transposon Tf2-9 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-9 SPBC9B6.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0005737; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P38486 CHOYP_LEG4.1.1 m.22079 sp LEG3_CANLF 37.652 247 114 14 46 263 59 294 4.47E-22 95.9 LEG3_CANLF reviewed Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (IgE-binding protein) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen) LGALS3 Canis lupus familiaris (Dog) (Canis familiaris) 296 cell differentiation [GO:0030154]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005576; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0030154; GO:0030246; GO:0045087 0 0 0 PF00337; P53500 CHOYP_LOC100888944.1.1 m.45112 sp ACT_CYAM1 29.787 376 239 11 611 977 9 368 4.47E-47 176 ACT_CYAM1 reviewed Actin CYME_CMM237C Cyanidioschyzon merolae (strain 10D) (Red alga) 377 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P54318 CHOYP_LIPR2.1.2 m.14918 sp LIPR2_RAT 42.958 284 151 6 21 297 5 284 4.47E-68 223 LIPR2_RAT reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) (Secretory glycoprotein GP-3) Pnliprp2 Plrp2 Rattus norvegicus (Rat) 468 galactolipid catabolic process [GO:0019376]; phospholipid catabolic process [GO:0009395]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0009395; GO:0009791; GO:0016298; GO:0019376; GO:0032094; GO:0033993; GO:0042589; GO:0043434; GO:0047372; GO:0047714; GO:0051384 0 0 0 PF00151;PF01477; Q08CS6 CHOYP_TRIADDRAFT_61434.1.1 m.8434 sp MOXD2_DANRE 28.226 124 85 2 700 823 46 165 4.47E-09 63.9 MOXD2_DANRE reviewed DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-) moxd2 moxd1l si:ch211-203k16.5 Danio rerio (Zebrafish) (Brachydanio rerio) 572 0 GO:0005507; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q20681 CHOYP_NEMVEDRAFT_V1G198958.1.6 m.10856 sp BAT38_CAEEL 37.415 147 88 3 18 161 229 374 4.47E-18 86.3 BAT38_CAEEL reviewed BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans 387 0 0 0 0 0 PF00651;PF00917; Q2QI47 CHOYP_BRAFLDRAFT_126919.1.1 m.33812 sp USH2A_MOUSE 21.285 794 441 34 270 998 4074 4748 4.47E-12 74.7 USH2A_MOUSE reviewed Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) 5193 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042803; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF00054;PF02210;PF00055; Q3UXZ6 CHOYP_BRAFLDRAFT_98567.1.2 m.57260 sp FA81A_MOUSE 27.559 254 167 4 32 276 38 283 4.47E-24 102 FA81A_MOUSE reviewed Protein FAM81A Fam81a Mus musculus (Mouse) 364 0 0 0 0 0 0 Q5BIR5 CHOYP_SERPINB3.2.2 m.54290 sp SPB8_BOVIN 39.2 375 217 7 37 403 3 374 4.47E-86 269 SPB8_BOVIN reviewed Serpin B8 SERPINB8 Bos taurus (Bovine) 374 0 GO:0004867; GO:0005615; GO:0005737; GO:0005829; GO:0070062 0 0 0 PF00079; Q5F479 CHOYP_BRAFLDRAFT_123981.1.1 m.9319 sp S11IP_CHICK 30.716 726 394 26 111 784 77 745 4.47E-71 263 S11IP_CHICK reviewed Serine/threonine-protein kinase 11-interacting protein STK11IP RCJMB04_2g8 Gallus gallus (Chicken) 1073 0 GO:0005737 0 0 0 PF15904; Q5TFE4 CHOYP_LOC100556034.2.2 m.15378 sp NT5D1_HUMAN 39.869 459 255 11 46 495 3 449 4.47E-101 313 NT5D1_HUMAN reviewed 5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-) NT5DC1 NT5C2L1 LP2642 Homo sapiens (Human) 455 0 GO:0008253; GO:0046872 0 0 0 PF05761; Q7TS72 CHOYP_LOC100878101.1.2 m.45667 sp IP3KC_MOUSE 43.796 274 146 2 168 437 406 675 4.47E-71 240 IP3KC_MOUSE reviewed "Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase C) (IP3 3-kinase C) (IP3K C) (InsP 3-kinase C)" Itpkc Mus musculus (Mouse) 678 mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005524; GO:0005654; GO:0005737; GO:0008440; GO:0098779; GO:0098792 0 0 0 PF03770; Q8BH75 CHOYP_LOC661626.1.1 m.53878 sp RNF41_MOUSE 67.619 315 102 0 1 315 1 315 4.47E-170 477 RNF41_MOUSE reviewed E3 ubiquitin-protein ligase NRDP1 (EC 6.3.2.-) (RING finger protein 41) Rnf41 Flrf Nrdp1 Mus musculus (Mouse) 317 autophagy [GO:0006914]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of macromitophagy [GO:1901525]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; proteasomal protein catabolic process [GO:0010498]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of lymphocyte differentiation [GO:0045619]; regulation of MAPK cascade [GO:0043408]; regulation of myeloid cell differentiation [GO:0045637]; regulation of protein kinase B signaling [GO:0051896]; regulation of reactive oxygen species metabolic process [GO:2000377] GO:0000209; GO:0004842; GO:0005128; GO:0005135; GO:0006914; GO:0008270; GO:0008285; GO:0010468; GO:0010498; GO:0016567; GO:0016881; GO:0017160; GO:0030336; GO:0031386; GO:0043408; GO:0045619; GO:0045637; GO:0051091; GO:0051865; GO:0051896; GO:0061630; GO:0097191; GO:1901525; GO:2000114; GO:2000377; GO:2000379 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF08941; Q8CJ61 CHOYP_CMTM4.1.1 m.33180 sp CKLF4_MOUSE 27.879 165 111 3 1 164 19 176 4.47E-10 60.1 CKLF4_MOUSE reviewed CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4) Cmtm4 Cklfsf4 Mus musculus (Mouse) 208 chemotaxis [GO:0006935] GO:0005615; GO:0006935; GO:0016021 0 0 0 PF01284; Q9BRZ2 CHOYP_BRAFLDRAFT_72273.1.2 m.34499 sp TRI56_HUMAN 30 150 83 4 9 148 12 149 4.47E-10 60.5 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9V5L3 CHOYP_BRAFLDRAFT_91870.1.3 m.13135 sp C49A1_DROME 28.437 531 330 16 23 522 76 587 4.47E-59 208 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q9XZC0 CHOYP_contig_028503 m.32444 sp LCTA_LATTR 28.488 172 99 6 737 886 676 845 4.47E-10 67.4 LCTA_LATTR reviewed Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1) (Fragment) 0 Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) 1413 exocytosis [GO:0006887] GO:0005576; GO:0006887; GO:0016021; GO:0072556 0 0 0 PF12796;PF13606; A0JPI9 CHOYP_BRAFLDRAFT_87451.2.4 m.22288 sp LR74A_RAT 31.944 432 273 8 100 523 48 466 4.48E-58 205 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A0QZA1 CHOYP_LOC100180023.5.7 m.56825 sp Y3950_MYCS2 28.571 154 94 4 4 153 10 151 4.48E-10 59.7 Y3950_MYCS2 reviewed Universal stress protein MSMEG_3950/MSMEI_3859 (USP MSMEG_3950) MSMEG_3950 MSMEI_3859 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 294 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; B5X2B8 CHOYP_ERAL1.1.1 m.28077 sp ERAL1_SALSA 35.176 398 220 10 69 460 91 456 4.48E-62 211 ERAL1_SALSA reviewed "GTPase Era, mitochondrial (ERA-like protein 1)" eral1 Salmo salar (Atlantic salmon) 457 ribosomal small subunit assembly [GO:0000028] GO:0000028; GO:0005525; GO:0005743; GO:0005759; GO:0019843; GO:0043024 0 0 cd04163; PF07650;PF01926; B9A8D7 CHOYP_SPI2.16.37 m.16200 sp SPI2_CRAVI 37.037 81 49 2 36 116 4 82 4.48E-07 47.4 SPI2_CRAVI reviewed Serine protease inhibitor Cvsi-2 CVSI2 Crassostrea virginica (Eastern oyster) 85 0 GO:0004867; GO:0005576 0 0 0 0 P10394 CHOYP_PMAR_PMAR027405.1.1 m.11716 sp POL4_DROME 30.181 772 470 14 1 732 470 1212 4.48E-98 337 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P16157 CHOYP_TVAG_168010.36.45 m.58881 sp ANK1_HUMAN 31.048 744 466 5 25 739 61 786 4.48E-100 343 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P35556 CHOYP_LOC100631495.1.1 m.9607 sp FBN2_HUMAN 33.824 952 512 33 1 849 792 1728 4.48E-103 373 FBN2_HUMAN reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] FBN2 Homo sapiens (Human) 2912 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cellular response to growth factor stimulus [GO:0090287]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0022617; GO:0030023; GO:0030198; GO:0030326; GO:0030501; GO:0031012; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346; GO:0090287 0 0 0 PF12662;PF07645;PF12661;PF00683; P62083 CHOYP_RS7.2.9 m.12674 sp RS7_RAT 75.781 128 30 1 1 127 1 128 4.48E-63 193 RS7_RAT reviewed 40S ribosomal protein S7 (S8) Rps7 Rattus norvegicus (Rat) 194 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0003735; GO:0005815; GO:0006364; GO:0006412; GO:0008266; GO:0022627; GO:0030686; GO:0032040; GO:0042274 0 0 0 PF01251; Q02152 CHOYP_LOC100331465.2.3 m.40294 sp 5HT2B_MOUSE 23.2 375 227 15 55 413 60 389 4.48E-07 55.5 5HT2B_MOUSE reviewed 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (5-HT-2F) (NP75 protein) (Serotonin receptor 2B) Htr2b Mus musculus (Mouse) 479 activation of phospholipase C activity [GO:0007202]; behavior [GO:0007610]; calcium-mediated signaling [GO:0019722]; cardiac muscle hypertrophy [GO:0003300]; cellular calcium ion homeostasis [GO:0006874]; cellular response to amine stimulus [GO:0071418]; cellular response to serotonin [GO:1904015]; cellular response to temperature stimulus [GO:0071502]; cGMP biosynthetic process [GO:0006182]; embryonic morphogenesis [GO:0048598]; ERK1 and ERK2 cascade [GO:0070371]; G-protein coupled receptor internalization [GO:0002031]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; hepatic stellate cell activation [GO:0035733]; inositol phosphate metabolic process [GO:0043647]; intestine smooth muscle contraction [GO:0014827]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cell death [GO:0060548]; neural crest cell differentiation [GO:0014033]; neural crest cell migration [GO:0001755]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; phosphorylation [GO:0016310]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein kinase C signaling [GO:0070528]; regulation of behavior [GO:0050795]; release of sequestered calcium ion into cytosol [GO:0051209]; response to drug [GO:0042493]; serotonin receptor signaling pathway [GO:0007210]; vasoconstriction [GO:0042310] GO:0001755; GO:0001819; GO:0001938; GO:0001965; GO:0002031; GO:0003007; GO:0003300; GO:0004993; GO:0005096; GO:0005737; GO:0005886; GO:0005887; GO:0006182; GO:0006874; GO:0007186; GO:0007202; GO:0007205; GO:0007208; GO:0007210; GO:0007507; GO:0007610; GO:0008144; GO:0008284; GO:0010507; GO:0010513; GO:0014033; GO:0014065; GO:0014827; GO:0016310; GO:0019722; GO:0030054; GO:0030425; GO:0035733; GO:0042310; GO:0042493; GO:0043025; GO:0043066; GO:0043123; GO:0043406; GO:0043647; GO:0045202; GO:0048598; GO:0050715; GO:0050795; GO:0051000; GO:0051209; GO:0051378; GO:0051781; GO:0060548; GO:0070371; GO:0070374; GO:0070528; GO:0071418; GO:0071502; GO:1904015 0 0 0 PF00001; Q12955 CHOYP_LOC100369608.3.3 m.31150 sp ANK3_HUMAN 32.335 167 104 3 653 819 48 205 4.48E-17 90.5 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q3TLH4 CHOYP_LOC100559941.2.2 m.62841 sp PRC2C_MOUSE 37.075 588 255 22 1 569 1 492 4.48E-62 241 PRC2C_MOUSE reviewed Protein PRRC2C (BAT2 domain-containing protein 1) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Prrc2c Bat2d Bat2d1 Bat2l2 Kiaa1096 Mus musculus (Mouse) 2846 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244; GO:0008022; GO:0016020; GO:0044822 0 0 0 PF07001; Q5W1J6 CHOYP_FOXM.1.1 m.47898 sp FOXM1_XENLA 36.726 226 111 6 517 731 197 401 4.48E-29 128 FOXM1_XENLA reviewed Forkhead box protein M1 (XlFoxM1) foxm1 Xenopus laevis (African clawed frog) 759 "cell cycle [GO:0007049]; DNA repair [GO:0006281]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006281; GO:0006351; GO:0007049; GO:0043565 0 0 0 PF00250; Q8BMB3 CHOYP_BRAFLDRAFT_265613.1.2 m.14785 sp IF4E2_MOUSE 61.146 157 46 1 14 155 1 157 4.48E-66 218 IF4E2_MOUSE reviewed Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (eIF4E-2) (mRNA cap-binding protein type 2) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) Eif4e2 Eif4el3 Mus musculus (Mouse) 245 in utero embryonic development [GO:0001701]; negative regulation of translation [GO:0017148] GO:0001701; GO:0003743; GO:0005737; GO:0005845; GO:0017148; GO:0031625; GO:0044822 0 0 0 PF01652; Q8BYM7 CHOYP_LOC100376902.1.1 m.20390 sp RSH4A_MOUSE 57.778 495 197 6 19 509 212 698 4.48E-178 521 RSH4A_MOUSE reviewed Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3) Rsph4a Rshl3 Mus musculus (Mouse) 716 axoneme assembly [GO:0035082]; cilium movement [GO:0003341] GO:0001534; GO:0003341; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005930; GO:0035082 0 0 0 PF04712; Q8UUG8 CHOYP_BRAFLDRAFT_77391.2.3 m.37730 sp 5HT2B_TETFL 22.843 394 244 14 54 414 15 381 4.48E-07 55.5 5HT2B_TETFL reviewed 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) htr2b Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) 471 behavior [GO:0007610]; embryonic morphogenesis [GO:0048598]; heart development [GO:0007507]; regulation of behavior [GO:0050795]; serotonin uptake [GO:0051610]; smooth muscle contraction [GO:0006939]; vasoconstriction [GO:0042310] GO:0001587; GO:0005887; GO:0006939; GO:0007507; GO:0007610; GO:0030054; GO:0030285; GO:0030594; GO:0042310; GO:0043005; GO:0048598; GO:0050795; GO:0051610 0 0 0 PF00001; Q91312 CHOYP_LOC100120946.1.1 m.48569 sp CRYAB_LITCT 34.711 121 74 3 9 127 48 165 4.48E-16 73.2 CRYAB_LITCT reviewed Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 173 0 GO:0005212; GO:0042803; GO:0046872 0 0 0 PF00525;PF00011; Q96EY1 CHOYP_contig_006299 m.7138 sp DNJA3_HUMAN 41.121 107 52 3 2 98 50 155 4.48E-15 77 DNJA3_HUMAN reviewed "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) 480 activation-induced cell death of T cells [GO:0006924]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell aging [GO:0007569]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of programmed cell death [GO:0043069]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to interferon-gamma [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] GO:0000122; GO:0005133; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006264; GO:0006457; GO:0006469; GO:0006919; GO:0006924; GO:0007005; GO:0007264; GO:0007528; GO:0007569; GO:0008134; GO:0008285; GO:0009408; GO:0019897; GO:0019901; GO:0030054; GO:0030695; GO:0031398; GO:0031594; GO:0032088; GO:0033077; GO:0034341; GO:0042102; GO:0042645; GO:0043065; GO:0043066; GO:0043069; GO:0043124; GO:0043154; GO:0043231; GO:0045211; GO:0046872; GO:0050821; GO:0051059; GO:0060336; GO:0071340 0 0 cd06257; PF00226;PF01556;PF00684; Q9H8Y8 CHOYP_BRAFLDRAFT_118294.1.2 m.11152 sp GORS2_HUMAN 54.293 396 140 8 3 366 2 388 4.48E-127 377 GORS2_HUMAN reviewed Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) GORASP2 GOLPH6 Homo sapiens (Human) 452 organelle organization [GO:0006996] GO:0000139; GO:0005794; GO:0006996; GO:0016020 0 0 0 PF04495; Q9HB97 CHOYP_PARVB.2.2 m.47698 sp PARVA_RAT 53.797 158 69 3 285 440 79 234 4.48E-41 156 PARVA_RAT reviewed Alpha-parvin (Actopaxin) Parva Actp Rattus norvegicus (Rat) 372 actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin-mediated cell contraction [GO:0070252]; cilium morphogenesis [GO:0060271]; establishment or maintenance of cell polarity [GO:0007163]; heterotypic cell-cell adhesion [GO:0034113]; outflow tract septum morphogenesis [GO:0003148]; protein heterooligomerization [GO:0051291]; regulation of cell shape [GO:0008360]; smooth muscle cell chemotaxis [GO:0071670]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446] GO:0002040; GO:0003148; GO:0005856; GO:0005886; GO:0005925; GO:0007163; GO:0008360; GO:0019904; GO:0030018; GO:0030036; GO:0031532; GO:0034113; GO:0034446; GO:0043234; GO:0051291; GO:0060271; GO:0070252; GO:0071670 0 0 0 PF00307; Q9NQR9 CHOYP_NEMVEDRAFT_V1G194144.1.1 m.32228 sp G6PC2_HUMAN 40 345 186 8 9 337 1 340 4.48E-76 241 G6PC2_HUMAN reviewed Glucose-6-phosphatase 2 (G-6-Pase 2) (G6Pase 2) (EC 3.1.3.9) (Islet-specific glucose-6-phosphatase catalytic subunit-related protein) G6PC2 IGRP Homo sapiens (Human) 355 gluconeogenesis [GO:0006094]; glucose 6-phosphate metabolic process [GO:0051156]; glucose homeostasis [GO:0042593]; glucose transport [GO:0015758]; regulation of insulin secretion [GO:0050796] GO:0004346; GO:0005789; GO:0006094; GO:0015758; GO:0030176; GO:0042593; GO:0050796; GO:0051156 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. 0 0 PF01569; Q9NYT6 CHOYP_ZN234.1.1 m.6832 sp ZN226_HUMAN 33.063 493 266 12 281 728 300 773 4.48E-71 254 ZN226_HUMAN reviewed Zinc finger protein 226 ZNF226 Homo sapiens (Human) 803 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q9VFD5 CHOYP_LOC100373140.7.11 m.36588 sp FEM1A_DROME 37.755 98 50 3 793 879 44 141 4.48E-07 57.4 FEM1A_DROME reviewed Protein fem-1 homolog CG6966 CG6966 Drosophila melanogaster (Fruit fly) 664 regulation of ubiquitin-protein transferase activity [GO:0051438] GO:0004842; GO:0051438 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF13606; Q9W704 CHOYP_BRAFLDRAFT_212934.1.1 m.1975 sp RIPA_XENLA 37.826 230 126 6 37 257 5 226 4.48E-43 149 RIPA_XENLA reviewed RPA-interacting protein A (RPA-interacting protein alpha) (XRIPalpha) rpain-a rip-a Xenopus laevis (African clawed frog) 226 0 GO:0005634; GO:0046872 0 0 0 PF14768;PF14767;PF14766; Q9WV92 CHOYP_41.2.3 m.31169 sp E41L3_MOUSE 58.529 340 135 4 4 342 120 454 4.48E-135 439 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; A4IF63 CHOYP_LOC100374741.37.83 m.33110 sp TRIM2_BOVIN 25.701 214 148 5 2 211 536 742 4.49E-11 65.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B0BNA5 CHOYP_NEMVEDRAFT_V1G237545.1.1 m.34854 sp COTL1_RAT 46.617 133 71 0 4 136 5 137 4.49E-37 126 COTL1_RAT reviewed Coactosin-like protein Cotl1 Clp Rattus norvegicus (Rat) 142 defense response to fungus [GO:0050832] GO:0005634; GO:0005737; GO:0005856; GO:0050832; GO:0070062 0 0 0 PF00241; O43639 CHOYP_LOC100533447.2.3 m.44497 sp NCK2_HUMAN 41.606 411 199 13 4 407 3 379 4.49E-96 295 NCK2_HUMAN reviewed Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) NCK2 GRB4 Homo sapiens (Human) 380 actin filament organization [GO:0007015]; cell migration [GO:0016477]; dendritic spine development [GO:0060996]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; immunological synapse formation [GO:0001771]; lamellipodium assembly [GO:0030032]; negative regulation of cell proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of epidermal growth factor-activated receptor activity [GO:0007176]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vesicle-mediated transport [GO:0016192] GO:0001771; GO:0005070; GO:0005086; GO:0005737; GO:0005783; GO:0005802; GO:0005829; GO:0007015; GO:0007165; GO:0007172; GO:0007173; GO:0007176; GO:0008093; GO:0008285; GO:0012506; GO:0016192; GO:0016477; GO:0030032; GO:0030159; GO:0030838; GO:0033137; GO:0036493; GO:0042102; GO:0042110; GO:0045202; GO:0045944; GO:0048010; GO:0048013; GO:0060996; GO:1902237; GO:1903898; GO:1903912; GO:1990441 0 0 0 PF00017;PF00018;PF14604; O43639 CHOYP_LOC658201.1.1 m.42879 sp NCK2_HUMAN 41.606 411 199 13 4 407 3 379 4.49E-96 295 NCK2_HUMAN reviewed Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) NCK2 GRB4 Homo sapiens (Human) 380 actin filament organization [GO:0007015]; cell migration [GO:0016477]; dendritic spine development [GO:0060996]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; immunological synapse formation [GO:0001771]; lamellipodium assembly [GO:0030032]; negative regulation of cell proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990441]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of translation in response to endoplasmic reticulum stress [GO:0036493]; regulation of epidermal growth factor-activated receptor activity [GO:0007176]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vesicle-mediated transport [GO:0016192] GO:0001771; GO:0005070; GO:0005086; GO:0005737; GO:0005783; GO:0005802; GO:0005829; GO:0007015; GO:0007165; GO:0007172; GO:0007173; GO:0007176; GO:0008093; GO:0008285; GO:0012506; GO:0016192; GO:0016477; GO:0030032; GO:0030159; GO:0030838; GO:0033137; GO:0036493; GO:0042102; GO:0042110; GO:0045202; GO:0045944; GO:0048010; GO:0048013; GO:0060996; GO:1902237; GO:1903898; GO:1903912; GO:1990441 0 0 0 PF00017;PF00018;PF14604; O54786 CHOYP_LOC100375419.1.1 m.60972 sp DFFA_MOUSE 31.579 171 103 3 19 180 33 198 4.49E-17 80.9 DFFA_MOUSE reviewed DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD) Dffa Icad Mus musculus (Mouse) 331 negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of apoptotic process [GO:0043065]; thymocyte apoptotic process [GO:0070242] GO:0000790; GO:0005634; GO:0005737; GO:0005829; GO:0043065; GO:0070242; GO:1900118; GO:1902511 0 0 0 PF02017;PF09033; O95671 CHOYP_LOC100378818.2.2 m.27217 sp ASML_HUMAN 47.727 220 103 3 18 234 2 212 4.49E-61 204 ASML_HUMAN reviewed N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-) ASMTL Homo sapiens (Human) 621 0 GO:0005737; GO:0008171 0 0 cd00555; PF16864;PF02545;PF00891; O97592 CHOYP_BRAFLDRAFT_90094.1.1 m.19745 sp DMD_CANLF 24.254 268 165 2 13 242 908 1175 4.49E-24 104 DMD_CANLF reviewed Dystrophin DMD Canis lupus familiaris (Dog) (Canis familiaris) 3680 muscle attachment [GO:0016203] GO:0005200; GO:0005737; GO:0005856; GO:0008270; GO:0016203; GO:0030054; GO:0042383; GO:0045211 0 0 0 PF00307;PF09068;PF09069;PF00435;PF00397;PF00569; P06916 CHOYP_contig_024779 m.28179 sp FIRA_PLAFF 40.594 101 60 0 27 127 29 129 4.49E-10 59.3 FIRA_PLAFF reviewed 300 kDa antigen AG231 (Fragment) FIRA Plasmodium falciparum (isolate FC27 / Papua New Guinea) 310 0 0 0 0 0 PF07016; P25786 CHOYP_PSA1.1.1 m.44276 sp PSA1_HUMAN 76.062 259 60 1 97 353 1 259 4.49E-151 429 PSA1_HUMAN reviewed Proteasome subunit alpha type-1 (EC 3.4.25.1) (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain) PSMA1 HC2 NU PROS30 PSC2 Homo sapiens (Human) 263 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0003723; GO:0004298; GO:0005634; GO:0005654; GO:0005813; GO:0005829; GO:0005839; GO:0005844; GO:0006521; GO:0019773; GO:0031145; GO:0033209; GO:0038061; GO:0038095; GO:0043161; GO:0043488; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070062; GO:0090090; GO:0090263 0 0 0 PF00227;PF10584; P26342 CHOYP_BRAFLDRAFT_86522.1.1 m.9213 sp TGBR3_RAT 23.918 878 502 31 1 782 8 815 4.49E-51 196 TGBR3_RAT reviewed Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III) Tgfbr3 Rattus norvegicus (Rat) 853 BMP signaling pathway [GO:0030509]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell growth [GO:0016049]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; negative regulation of cellular component movement [GO:0051271]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; organ regeneration [GO:0031100]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein complex assembly [GO:0006461]; regulation of protein binding [GO:0043393]; response to follicle-stimulating hormone [GO:0032354]; response to hypoxia [GO:0001666]; response to luteinizing hormone [GO:0034699]; response to prostaglandin E [GO:0034695]; signal transduction [GO:0007165]; transforming growth factor beta receptor complex assembly [GO:0007181]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0001666; GO:0005024; GO:0005160; GO:0005539; GO:0005578; GO:0005615; GO:0005737; GO:0005887; GO:0006461; GO:0006955; GO:0007165; GO:0007179; GO:0007181; GO:0008201; GO:0009897; GO:0015026; GO:0016021; GO:0016049; GO:0017134; GO:0030509; GO:0030511; GO:0030512; GO:0031012; GO:0031100; GO:0032354; GO:0034673; GO:0034695; GO:0034699; GO:0035556; GO:0043235; GO:0043393; GO:0048185; GO:0050431; GO:0051271; GO:0060317; GO:0060389; GO:0070062; GO:0070123 0 0 0 PF00100; P34456 CHOYP_LOC588385.2.2 m.64072 sp YMD2_CAEEL 23.38 432 279 16 15 413 2 414 4.49E-19 92 YMD2_CAEEL reviewed Uncharacterized protein F54H12.2 F54H12.2 Caenorhabditis elegans 419 deoxyribonucleotide biosynthetic process [GO:0009263] GO:0004748; GO:0005971; GO:0009263 0 0 0 0 P51147 CHOYP_LOC578627.1.1 m.61950 sp RAB5C_CANLF 83.256 215 32 3 1 212 1 214 4.49E-127 360 RAB5C_CANLF reviewed Ras-related protein Rab-5C RAB5C Canis lupus familiaris (Dog) (Canis familiaris) 216 plasma membrane to endosome transport [GO:0048227]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005765; GO:0005769; GO:0005811; GO:0005886; GO:0007264; GO:0015031; GO:0019003; GO:0030100; GO:0030139; GO:0031901; GO:0042470; GO:0048227; GO:0070062 0 0 0 PF00071; Q4PZA2 CHOYP_LOC100215799.1.1 m.27161 sp ECE1_MOUSE 27.972 143 85 5 270 397 629 768 4.49E-06 52.4 ECE1_MOUSE reviewed Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) Ece1 Mus musculus (Mouse) 769 apoptotic process [GO:0006915]; bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; endothelin maturation [GO:0034959]; heart development [GO:0007507]; hormone catabolic process [GO:0042447]; peptide hormone processing [GO:0016486]; pharyngeal system development [GO:0060037]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of G-protein coupled receptor protein signaling pathway [GO:0045745]; positive regulation of receptor recycling [GO:0001921]; protein processing [GO:0016485]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of vasodilation [GO:0042312]; response to cadmium ion [GO:0046686]; response to drug [GO:0042493]; response to hypoxia [GO:0001666]; response to muscle stretch [GO:0035994]; substance P catabolic process [GO:0010814] GO:0001666; GO:0001921; GO:0004175; GO:0004222; GO:0005765; GO:0005768; GO:0005769; GO:0005794; GO:0006915; GO:0007507; GO:0009897; GO:0009986; GO:0010613; GO:0010814; GO:0010815; GO:0010816; GO:0016020; GO:0016021; GO:0016485; GO:0016486; GO:0030819; GO:0033093; GO:0034959; GO:0035994; GO:0042312; GO:0042447; GO:0042493; GO:0042733; GO:0042803; GO:0043583; GO:0045745; GO:0046686; GO:0046872; GO:0048471; GO:0060037; GO:0070062; GO:0070372 0 0 cd08662; PF01431;PF05649; Q6P2C0 CHOYP_LOC100370122.2.2 m.59310 sp WDR93_HUMAN 25.173 723 475 18 2 710 15 685 4.49E-69 243 WDR93_HUMAN reviewed WD repeat-containing protein 93 WDR93 Homo sapiens (Human) 686 electron transport chain [GO:0022900] GO:0016651; GO:0022900 0 0 0 0 Q6P926 CHOYP_LOC100367461.1.1 m.11630 sp SPA24_MOUSE 30.698 215 123 2 24 238 6 194 4.49E-27 106 SPA24_MOUSE reviewed Spermatogenesis-associated protein 24 (TATA-binding protein-like factor-interacting protein) (TLF-interacting protein) (TRF2-interacting protein in testis) (Testis protein T6441 homolog) Spata24 Tipt Tipt2 Mus musculus (Mouse) 205 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0007275; GO:0007283; GO:0030154; GO:0042803 0 0 0 PF15175; Q80TI0 CHOYP_GRM1B.1.1 m.31435 sp GRM1B_MOUSE 37.5 680 345 19 266 881 61 724 4.49E-139 434 GRM1B_MOUSE reviewed GRAM domain-containing protein 1B Gramd1b Kiaa1201 Mus musculus (Mouse) 738 0 GO:0016020; GO:0016021 0 0 0 PF16016;PF02893; Q96CA5 CHOYP_LOC100122438.1.2 m.38157 sp BIRC7_HUMAN 35.577 104 64 2 86 189 198 298 4.49E-13 69.3 BIRC7_HUMAN reviewed Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)] BIRC7 KIAP LIVIN MLIAP RNF50 UNQ5800/PRO19607/PRO21344 Homo sapiens (Human) 298 activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127]; regulation of natural killer cell apoptotic process [GO:0070247]; regulation of signal transduction [GO:0009966] GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005794; GO:0005876; GO:0006915; GO:0007257; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0019899; GO:0042127; GO:0043066; GO:0070247; GO:0090307; GO:1990001 0 0 0 PF00653; Q96GP6 CHOYP_CED1.27.29 m.61057 sp SREC2_HUMAN 37.705 122 67 6 43 162 216 330 4.49E-10 62.8 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9VVE5 CHOYP_MSI2H.2.3 m.31545 sp MSIR6_DROME 51.986 277 102 8 10 282 98 347 4.49E-75 238 MSIR6_DROME reviewed RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) 369 stem cell development [GO:0048864] GO:0000166; GO:0003727; GO:0005737; GO:0005844; GO:0008266; GO:0048864 0 0 0 PF00076; A0JM23 CHOYP_LOC100369926.6.6 m.56447 sp NPHP3_XENTR 26.946 167 119 3 214 379 1108 1272 4.50E-07 56.6 NPHP3_XENTR reviewed Nephrocystin-3 nphp3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1311 "cilium morphogenesis [GO:0060271]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000095]; Wnt signaling pathway [GO:0016055]" GO:0005929; GO:0016055; GO:0060271; GO:0072372; GO:0090090; GO:2000095 0 0 0 PF13176; A5YM72 CHOYP_LOC100557340.1.1 m.25176 sp CRNS1_HUMAN 54.545 99 44 1 1 98 644 742 4.50E-31 118 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 G5ED84 CHOYP_BACH1.6.17 m.11510 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 4.50E-11 69.7 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O08807 CHOYP_ISCW_ISCW013767.1.1 m.29335 sp PRDX4_MOUSE 75 224 54 1 26 247 51 274 4.50E-125 358 PRDX4_MOUSE reviewed Peroxiredoxin-4 (EC 1.11.1.15) (Antioxidant enzyme AOE372) (Peroxiredoxin IV) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent peroxide reductase A0372) Prdx4 Mus musculus (Mouse) 274 4-hydroxyproline metabolic process [GO:0019471]; cell redox homeostasis [GO:0045454]; extracellular matrix organization [GO:0030198]; male gonad development [GO:0008584]; negative regulation of male germ cell proliferation [GO:2000255]; oxidation-reduction process [GO:0055114]; protein maturation by protein folding [GO:0022417]; reactive oxygen species metabolic process [GO:0072593]; spermatogenesis [GO:0007283] GO:0004601; GO:0005615; GO:0005634; GO:0005737; GO:0005739; GO:0005783; GO:0005790; GO:0005829; GO:0007283; GO:0008584; GO:0019471; GO:0022417; GO:0030198; GO:0042803; GO:0045454; GO:0051920; GO:0055114; GO:0070062; GO:0072593; GO:2000255 0 0 0 PF10417;PF00578; O43447 CHOYP_RS9.10.13 m.48533 sp PPIH_HUMAN 79.339 121 24 1 1 121 58 177 4.50E-68 205 PPIH_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) PPIH CYP20 CYPH Homo sapiens (Human) 177 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein complex assembly [GO:0006461]; protein folding [GO:0006457]" GO:0000398; GO:0003755; GO:0005654; GO:0005681; GO:0005737; GO:0006457; GO:0006461; GO:0016018; GO:0016607; GO:0043021; GO:0045070; GO:0046540; GO:0071001 0 0 0 PF00160; O43447 CHOYP_RS9.11.13 m.49923 sp PPIH_HUMAN 79.339 121 24 1 1 121 58 177 4.50E-68 205 PPIH_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP) PPIH CYP20 CYPH Homo sapiens (Human) 177 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of viral genome replication [GO:0045070]; protein complex assembly [GO:0006461]; protein folding [GO:0006457]" GO:0000398; GO:0003755; GO:0005654; GO:0005681; GO:0005737; GO:0006457; GO:0006461; GO:0016018; GO:0016607; GO:0043021; GO:0045070; GO:0046540; GO:0071001 0 0 0 PF00160; P35003 CHOYP_CTRL.1.1 m.48654 sp CTRL_HALRU 42.471 259 113 8 48 290 14 252 4.50E-57 187 CTRL_HALRU reviewed Chymotrypsin-like serine proteinase (EC 3.4.21.-) 0 Haliotis rufescens (California red abalone) 254 0 GO:0004252; GO:0005615 0 0 cd00190; PF00089; Q09738 CHOYP_LOC100815856.1.1 m.63640 sp UBP8_SCHPO 24.224 322 204 10 611 923 146 436 4.50E-18 91.7 UBP8_SCHPO reviewed Probable ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) ubp8 SPAC13A11.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 449 histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; protein deubiquitination [GO:0016579]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000124; GO:0004843; GO:0005634; GO:0005654; GO:0006357; GO:0006511; GO:0008270; GO:0016579; GO:0035616 0 0 0 PF00443;PF02148; Q10901 CHOYP_LOC592280.2.2 m.42629 sp EAA1_CAEEL 36.681 458 273 5 22 472 16 463 4.50E-101 315 EAA1_CAEEL reviewed Excitatory amino acid transporter (Sodium-dependent glutamate/ aspartate transporter) glt-1 C12D12.2 Caenorhabditis elegans 503 0 GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0042995 0 0 0 PF00375; Q12912 CHOYP_LOC100379008.4.4 m.54023 sp LRMP_HUMAN 43.716 183 95 4 332 512 206 382 4.50E-33 138 LRMP_HUMAN reviewed Lymphoid-restricted membrane protein (Protein Jaw1) [Cleaved into: Processed lymphoid-restricted membrane protein] LRMP JAW1 Homo sapiens (Human) 555 immune system process [GO:0002376]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903] GO:0000922; GO:0002376; GO:0005635; GO:0005694; GO:0005789; GO:0005815; GO:0005887; GO:0006903; GO:0006906; GO:0007338; GO:0016020; GO:0016021 0 0 0 PF05781; Q3V2K1 CHOYP_LOC756370.1.1 m.62527 sp CX065_MOUSE 31.724 145 90 3 10 145 2 146 4.50E-11 61.2 CX065_MOUSE reviewed Uncharacterized protein CXorf65 homolog Gm614 Mus musculus (Mouse) 191 0 0 0 0 0 0 Q4R4Y9 CHOYP_EIF4A1.1.1 m.55580 sp IF4A2_MACFA 73.6 125 26 1 8 132 4 121 4.50E-56 182 IF4A2_MACFA reviewed Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) EIF4A2 QnpA-20305 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 408 regulation of translational initiation [GO:0006446] GO:0003743; GO:0004004; GO:0005524; GO:0006446 0 0 0 PF00270;PF00271; Q6DJF8 CHOYP_MET23.1.1 m.14359 sp MET23_XENLA 54.128 218 98 1 5 220 11 228 4.50E-86 257 MET23_XENLA reviewed Methyltransferase-like protein 23 (EC 2.1.1.-) mettl23 Xenopus laevis (African clawed frog) 234 0 GO:0005737; GO:0008168; GO:0016021 0 0 0 PF10294; Q8WYH8 CHOYP_STK11.1.1 m.19138 sp ING5_HUMAN 63.306 248 77 2 1 243 1 239 4.50E-110 319 ING5_HUMAN reviewed Inhibitor of growth protein 5 (p28ING5) ING5 Homo sapiens (Human) 240 "chromatin modification [GO:0016568]; DNA replication [GO:0006260]; histone H3 acetylation [GO:0043966]; negative regulation of cell proliferation [GO:0008285]; negative regulation of growth [GO:0045926]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of transcription, DNA-templated [GO:0045893]; protein acetylation [GO:0006473]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0005634; GO:0005654; GO:0006260; GO:0006351; GO:0006473; GO:0008270; GO:0008285; GO:0016568; GO:0035064; GO:0043065; GO:0043966; GO:0045893; GO:0045926; GO:0070776; GO:1901796; GO:2001235 0 0 0 PF12998; Q90705 CHOYP_EEF2.1.2 m.44026 sp EF2_CHICK 77.108 166 37 1 4 169 568 732 4.50E-86 272 EF2_CHICK reviewed Elongation factor 2 (EF-2) EEF2 Gallus gallus (Chicken) 858 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; Q91WM2 CHOYP_CECR5.1.1 m.40219 sp CECR5_MOUSE 52.349 149 64 2 16 161 185 329 4.50E-49 167 CECR5_MOUSE reviewed Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) 419 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q95L73 CHOYP_BRAFLDRAFT_58490.1.1 m.51919 sp CY24A_BISBI 52.113 142 66 1 1 142 1 140 4.50E-46 152 CY24A_BISBI reviewed Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22 phagocyte B-cytochrome) (p22-phox) (p22phox) CYBA Bison bison (American bison) (Bos bison) 191 0 GO:0016491; GO:0020037; GO:0043020; GO:0046872 0 0 0 PF05038; Q96J86 CHOYP_BRAFLDRAFT_108183.1.1 m.988 sp CYYR1_HUMAN 30.709 127 60 6 120 226 30 148 4.50E-06 49.3 CYYR1_HUMAN reviewed Cysteine and tyrosine-rich protein 1 (Proline-rich domain-containing protein) CYYR1 C21orf95 Homo sapiens (Human) 154 0 GO:0016021 0 0 0 PF10873; Q96RW7 CHOYP_UNC89.6.19 m.33987 sp HMCN1_HUMAN 25.858 379 244 18 236 609 3640 3986 4.50E-10 68.6 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99M80 CHOYP_LOC577935.1.1 m.157 sp PTPRT_MOUSE 28.438 429 276 11 5 412 1035 1453 4.50E-43 165 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_109857.9.15 m.34558 sp TRIM2_MOUSE 27.536 207 132 8 124 326 539 731 4.50E-09 61.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NUV9 CHOYP_LOC100943882.1.1 m.56970 sp GIMA4_HUMAN 47.368 209 108 1 23 231 30 236 4.50E-62 204 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9ULD5 CHOYP_BRAFLDRAFT_283093.1.1 m.15039 sp ZN777_HUMAN 38.776 98 50 3 574 665 649 742 4.50E-10 66.6 ZN777_HUMAN reviewed Zinc finger protein 777 ZNF777 KIAA1285 Homo sapiens (Human) 760 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF12417;PF01352;PF00096; A1A4L0 CHOYP_BRAFLDRAFT_120826.1.1 m.56321 sp SNX4_BOVIN 55.224 402 169 4 36 432 55 450 4.51E-161 464 SNX4_BOVIN reviewed Sorting nexin-4 SNX4 Bos taurus (Bovine) 450 endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; positive regulation of histamine secretion by mast cell [GO:1903595]; protein transport [GO:0015031]; vesicle organization [GO:0016050] GO:0005768; GO:0005868; GO:0005886; GO:0006897; GO:0015031; GO:0016050; GO:0019898; GO:0031201; GO:0031901; GO:0032456; GO:0035091; GO:1903595 0 0 0 PF00787; B1ATG9 CHOYP_TIKI1.1.1 m.30212 sp TIKI2_MOUSE 49.197 498 205 6 21 477 24 514 4.51E-163 474 TIKI2_MOUSE reviewed "Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein) (TRAB domain-containing protein 2B)" Trabd2b Gm12824 Hkat Tiki2 Mus musculus (Mouse) 517 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of protein oxidation [GO:1904808]; protein oxidation [GO:0018158]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055] GO:0004222; GO:0005887; GO:0006508; GO:0016055; GO:0017147; GO:0018158; GO:0030178; GO:0031301; GO:0032461; GO:0046872; GO:0070062; GO:1904808 0 0 0 PF01963; D2GXS7 CHOYP_BRAFLDRAFT_241726.9.22 m.32384 sp TRIM2_AILME 30.588 85 53 2 1 81 622 704 4.51E-06 47.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P12804 CHOYP_FGL2.7.9 m.52541 sp FGL2_MOUSE 40.789 228 116 5 113 324 205 429 4.51E-49 172 FGL2_MOUSE reviewed Fibroleukin (Cytotoxic T-lymphocyte-specific protein) (Fibrinogen-like protein 2) (Prothrombinase) Fgl2 Fiblp Mus musculus (Mouse) 432 cytolysis [GO:0019835] GO:0008233; GO:0019835; GO:0070062 0 0 0 PF00147; Q07E01 CHOYP_BRAFLDRAFT_118213.2.2 m.54232 sp MET_ORNAN 28.933 1424 814 45 30 1356 40 1362 4.51E-158 516 MET_ORNAN reviewed Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Ornithorhynchus anatinus (Duckbill platypus) 1382 positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; semaphorin-plexin signaling pathway [GO:0071526]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0016021; GO:0050918; GO:0071526; GO:2001028 0 0 0 PF07714;PF01403;PF01833; Q13231 CHOYP_BRAFLDRAFT_281651.7.8 m.47024 sp CHIT1_HUMAN 52 75 35 1 1 74 312 386 4.51E-22 92.8 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q14AW5 CHOYP_LOC583012.1.1 m.5105 sp NSUN7_MOUSE 41.463 451 254 6 136 581 92 537 4.51E-105 339 NSUN7_MOUSE reviewed Putative methyltransferase NSUN7 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 7) Nsun7 Mus musculus (Mouse) 724 sperm mitochondrion organization [GO:0030382]; sperm motility [GO:0030317] GO:0003723; GO:0008168; GO:0030317; GO:0030382 0 0 0 PF01189; Q39056 CHOYP_MTR_5G015740.1.1 m.28468 sp CNX3_ARATH 55.102 147 66 0 67 213 116 262 4.51E-50 166 CNX3_ARATH reviewed "Cyclic pyranopterin monophosphate synthase accessory protein, mitochondrial (Molybdenum cofactor biosynthesis enzyme CNX3) (Molybdenum cofactor biosynthesis protein C) (Molybdopterin biosynthesis protein CNX3)" CNX3 At1g01290 F6F3.9 Arabidopsis thaliana (Mouse-ear cress) 270 Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0005739; GO:0005759; GO:0006777; GO:0009507; GO:0061597 PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. 0 cd01420; PF01967; Q3SZZ7 CHOYP_BRAFLDRAFT_125263.5.9 m.52531 sp FGL1_BOVIN 44.493 227 104 6 119 327 82 304 4.51E-51 174 FGL1_BOVIN reviewed Fibrinogen-like protein 1 FGL1 Bos taurus (Bovine) 312 0 GO:0070062 0 0 0 PF00147; Q3ZBG9 CHOYP_LOC755959.1.2 m.31069 sp PLS2_BOVIN 41.667 252 131 4 6 250 49 291 4.51E-68 214 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q4P821 CHOYP_AAEL_AAEL010363.1.1 m.18450 sp COX19_USTMA 51.613 62 30 0 31 92 17 78 4.51E-19 80.1 COX19_USTMA reviewed Cytochrome c oxidase assembly protein COX19 COX19 UMAG_12241 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 176 aerobic respiration [GO:0009060]; mitochondrial respiratory chain complex IV assembly [GO:0033617] GO:0005758; GO:0009060; GO:0033617 0 0 0 PF06747; Q4UMH6 CHOYP_DDB_G0276013.1.1 m.21466 sp Y381_RICFE 30.857 175 104 6 37 211 761 918 4.51E-08 56.2 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5R5M4 CHOYP_PHUM_PHUM278220.1.1 m.58696 sp MOT9_PONAB 24.429 569 319 15 14 564 8 483 4.51E-33 136 MOT9_PONAB reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 509 0 GO:0005886; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q6Q899 CHOYP_IFIH1.7.14 m.46974 sp DDX58_MOUSE 28.039 913 604 23 925 1805 20 911 4.51E-82 295 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6XIM8 CHOYP_RS15A.7.11 m.27963 sp RS15A_DROYA 82.692 104 13 1 1 104 1 99 4.51E-58 178 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q86VZ4 CHOYP_contig_031299 m.35727 sp LRP11_HUMAN 32.432 148 84 2 877 1016 361 500 4.51E-12 73.6 LRP11_HUMAN reviewed Low-density lipoprotein receptor-related protein 11 (LRP-11) LRP11 Homo sapiens (Human) 500 multicellular organismal response to stress [GO:0033555]; response to cold [GO:0009409]; response to heat [GO:0009408]; response to immobilization stress [GO:0035902]; response to mechanical stimulus [GO:0009612]; response to starvation [GO:0042594]; response to water deprivation [GO:0009414] GO:0005886; GO:0009408; GO:0009409; GO:0009414; GO:0009612; GO:0016021; GO:0033555; GO:0035902; GO:0042594; GO:0051219 0 0 0 PF00057;PF07502; Q8IWZ3 CHOYP_LOC581927.3.27 m.14274 sp ANKH1_HUMAN 35.952 420 244 15 118 519 212 624 4.51E-48 182 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q9CQQ8 CHOYP_LSM7.1.1 m.3617 sp LSM7_MOUSE 84.848 99 15 0 28 126 3 101 4.51E-58 177 LSM7_MOUSE reviewed U6 snRNA-associated Sm-like protein LSm7 Lsm7 Mus musculus (Mouse) 103 "mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]" GO:0000398; GO:0003723; GO:0005688; GO:0005689; GO:0005732; GO:0005737; GO:0006396; GO:0006402; GO:0046982; GO:0071004; GO:0071013; GO:0097526; GO:1990726 0 0 0 PF01423; Q9ESN6 CHOYP_BRAFLDRAFT_92727.6.17 m.32772 sp TRIM2_MOUSE 26.852 216 142 7 74 282 536 742 4.51E-09 60.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y3Y2 CHOYP_contig_034615 m.39310 sp CHTOP_HUMAN 63.889 36 9 1 67 102 211 242 4.51E-08 52 CHTOP_HUMAN reviewed Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) CHTOP C1orf77 FOP HT031 PP7704 Homo sapiens (Human) 248 "mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; positive regulation of ATPase activity [GO:0032781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of helicase activity [GO:0051096]; positive regulation of histone methylation [GO:0031062]; regulation of transcription, DNA-templated [GO:0006355]; RNA export from nucleus [GO:0006405]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000346; GO:0005654; GO:0005730; GO:0006355; GO:0006369; GO:0006405; GO:0006406; GO:0008284; GO:0008327; GO:0016607; GO:0031062; GO:0031124; GO:0032781; GO:0043231; GO:0044822; GO:0051096 0 0 0 PF13865; A6NMZ7 CHOYP_LOC100708991.3.5 m.40072 sp CO6A6_HUMAN 28.678 401 252 11 48 445 618 987 4.52E-38 151 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; O08605 CHOYP_LOC100373864.2.2 m.55131 sp MKNK1_MOUSE 56.345 394 148 5 71 460 35 408 4.52E-152 443 MKNK1_MOUSE reviewed MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) Mknk1 Mnk1 Mus musculus (Mouse) 427 extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of translation [GO:0006417]; response to salt stress [GO:0009651] GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006417; GO:0006468; GO:0009651; GO:0009931; GO:0018105; GO:0035556; GO:0046777; GO:0097192 0 0 0 PF00069; O08605 CHOYP_PCDH9.4.5 m.58559 sp MKNK1_MOUSE 56.345 394 148 5 71 460 35 408 4.52E-152 443 MKNK1_MOUSE reviewed MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) Mknk1 Mnk1 Mus musculus (Mouse) 427 extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of translation [GO:0006417]; response to salt stress [GO:0009651] GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0006417; GO:0006468; GO:0009651; GO:0009931; GO:0018105; GO:0035556; GO:0046777; GO:0097192 0 0 0 PF00069; O08863 CHOYP_LOC100882826.2.2 m.63576 sp BIRC3_MOUSE 35.632 87 51 2 128 212 498 581 4.52E-10 62 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; P05450 CHOYP_BRAFLDRAFT_67226.1.1 m.38034 sp YAT7_RHOBL 34.831 89 54 2 40 128 20 104 4.52E-10 56.2 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P22105 CHOYP_TVAG_486210.2.3 m.5640 sp TENX_HUMAN 26.587 252 124 14 31 255 273 490 4.52E-06 52.4 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P70193 CHOYP_BRAFLDRAFT_95739.1.2 m.53575 sp LRIG1_MOUSE 26 450 247 13 105 545 123 495 4.52E-19 97.4 LRIG1_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) Lrig1 Mus musculus (Mouse) 1091 innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605] GO:0007605; GO:0016021; GO:0032474; GO:0060384 0 0 0 PF07679;PF13855;PF01463;PF01462; P78329 CHOYP_BRAFLDRAFT_61250.3.14 m.15122 sp CP4F2_HUMAN 38.854 157 87 4 45 197 61 212 4.52E-30 118 CP4F2_HUMAN reviewed Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.13.194) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.13.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.13.30) CYP4F2 Homo sapiens (Human) 520 arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; oxidation-reduction process [GO:0055114]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377] GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006690; GO:0006691; GO:0007596; GO:0008217; GO:0008392; GO:0016324; GO:0016709; GO:0017144; GO:0018685; GO:0019369; GO:0019373; GO:0020037; GO:0031090; GO:0032304; GO:0032305; GO:0036101; GO:0042360; GO:0042361; GO:0042376; GO:0042377; GO:0043231; GO:0050051; GO:0052869; GO:0052871; GO:0052872; GO:0055078; GO:0055114; GO:0097258; GO:0097259; GO:0097267 PATHWAY: Cofactor degradation; phylloquinone degradation. {ECO:0000269|PubMed:24138531}. 0 0 PF00067; P78424 CHOYP_PO6F2.1.1 m.47093 sp PO6F2_HUMAN 51.743 373 104 11 152 480 334 674 4.52E-95 305 PO6F2_HUMAN reviewed "POU domain, class 6, transcription factor 2 (Retina-derived POU domain factor 1) (RPF-1)" POU6F2 RPF1 Homo sapiens (Human) 691 "central nervous system development [GO:0007417]; ganglion mother cell fate determination [GO:0007402]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]; visual perception [GO:0007601]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0006366; GO:0007402; GO:0007417; GO:0007601 0 0 0 PF00046;PF00157; P86854 CHOYP_MRC1.3.4 m.58267 sp PLCL_MYTGA 26.866 134 90 4 29 161 30 156 4.52E-10 58.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q0Q029 CHOYP_LOC658370.2.2 m.31194 sp DFP1_ANTMY 28.902 173 104 4 1 172 1 155 4.52E-16 76.3 DFP1_ANTMY reviewed Putative defense protein 1 (DFP-1) 0 Antheraea mylitta (Tasar silkworm) 168 defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087] GO:0005576; GO:0042742; GO:0042832; GO:0045087 0 0 cd08544; PF02014; Q3SX00 CHOYP_ANR46.1.1 m.11645 sp ANR46_BOVIN 29.949 197 105 1 31 194 31 227 4.52E-18 82 ANR46_BOVIN reviewed Ankyrin repeat domain-containing protein 46 ANKRD46 Bos taurus (Bovine) 228 0 GO:0016021 0 0 0 PF12796; Q4LDE5 CHOYP_NEMVEDRAFT_V1G202195.3.4 m.37651 sp SVEP1_HUMAN 32.022 178 97 5 29 201 1002 1160 4.52E-14 76.3 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q567G6 CHOYP_LOC100679572.1.1 m.17610 sp NEPRO_DANRE 27.586 145 100 1 62 201 49 193 4.52E-12 72.4 NEPRO_DANRE reviewed Protein nepro homolog nepro si:dkey-22a1.3 zgc:112065 Danio rerio (Zebrafish) (Brachydanio rerio) 525 negative regulation of neuron differentiation [GO:0045665]; positive regulation of Notch signaling pathway [GO:0045747] GO:0005634; GO:0005730; GO:0045665; GO:0045747 0 0 0 PF14780; Q5BKL8 CHOYP_ZF_RING_-24.1.1 m.2241 sp XIAP_XENTR 30.952 126 74 4 18 135 37 157 4.52E-10 60.5 XIAP_XENTR reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 492 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of proteolysis [GO:0045861]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005737; GO:0007275; GO:0008270; GO:0016055; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0045861; GO:0090263; GO:1990001 0 0 0 PF00653; Q5RJ80 CHOYP_contig_002843 m.3161 sp CAPR2_DANRE 31.915 141 81 6 179 318 785 911 4.52E-07 55.1 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q63073 CHOYP_PHUM_PHUM596890.1.1 m.10990 sp BTG1_RAT 46.584 161 81 2 1 156 11 171 4.52E-47 154 BTG1_RAT reviewed Protein BTG1 (Anti-proliferative factor) (B-cell translocation gene 1 protein) Btg1 Rattus norvegicus (Rat) 171 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein methylation [GO:0006479]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0006479; GO:0006979; GO:0007283; GO:0007286; GO:0008285; GO:0019899; GO:0043434; GO:0045603; GO:0045766; GO:2000271 0 0 0 PF07742; Q69ZW3 CHOYP_LOC100122021.1.1 m.17106 sp EHBP1_MOUSE 70.968 124 36 0 2 125 3 126 4.52E-58 196 EHBP1_MOUSE reviewed EH domain-binding protein 1 Ehbp1 Kiaa0903 Mus musculus (Mouse) 1231 0 GO:0005737; GO:0005886 0 0 0 PF00307;PF12130;PF10358; Q6PGQ7 CHOYP_BORA.1.1 m.14974 sp BORA_HUMAN 31.835 267 133 10 145 394 21 255 4.52E-22 104 BORA_HUMAN reviewed Protein aurora borealis (HsBora) BORA C13orf34 Homo sapiens (Human) 559 cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; regulation of mitotic nuclear division [GO:0007088]; regulation of mitotic spindle organization [GO:0060236]; regulation of protein localization [GO:0032880] GO:0000086; GO:0005829; GO:0007067; GO:0007088; GO:0019901; GO:0032880; GO:0051301; GO:0060236 0 0 0 PF15280; Q7Z402 CHOYP_LOC100888087.1.1 m.16016 sp TMC7_HUMAN 31.303 706 434 15 287 973 43 716 4.52E-103 341 TMC7_HUMAN reviewed Transmembrane channel-like protein 7 TMC7 Homo sapiens (Human) 723 ion transport [GO:0006811] GO:0006811; GO:0016021 0 0 0 PF07810; Q8MJU1 CHOYP_CASP7.16.23 m.50828 sp CASP3_FELCA 32.576 132 70 5 17 144 78 194 4.52E-09 57.8 CASP3_FELCA reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Felis catus (Cat) (Felis silvestris catus) 277 erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182] GO:0005737; GO:0030182; GO:0030216; GO:0030218; GO:0097194; GO:0097200 0 0 0 0 Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.9.34 m.28637 sp VWDE_HUMAN 23.161 367 231 12 383 714 744 1094 4.52E-16 86.7 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q99LG0 CHOYP_LOC585494.1.1 m.64158 sp UBP16_MOUSE 39.907 431 207 9 14 431 1 392 4.52E-87 301 UBP16_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) Usp16 Mus musculus (Mouse) 825 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; histone deubiquitination [GO:0016578]; histone H2A K63-linked deubiquitination [GO:0070537]; mitotic nuclear division [GO:0007067]; monoubiquitinated histone H2A deubiquitination [GO:0035522]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of translational elongation [GO:0045901]; protein homotetramerization [GO:0051289]; regulation of cell cycle [GO:0051726]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0003713; GO:0004197; GO:0004843; GO:0005634; GO:0006351; GO:0006357; GO:0006511; GO:0006974; GO:0007067; GO:0008270; GO:0016578; GO:0035522; GO:0042393; GO:0043130; GO:0045893; GO:0045901; GO:0045944; GO:0051289; GO:0051301; GO:0051726; GO:0070537 0 0 0 PF00443;PF02148; Q99NH0 CHOYP_LOC753709.5.44 m.17073 sp ANR17_MOUSE 36.087 460 273 14 50 495 233 685 4.52E-54 200 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9D8P7 CHOYP_GTF3C6.1.1 m.24023 sp TF3C6_MOUSE 39.252 107 51 2 32 134 29 125 4.52E-15 73.6 TF3C6_MOUSE reviewed General transcription factor 3C polypeptide 6 (Transcription factor IIIC 35 kDa subunit) (TFIIIC 35 kDa subunit) (TFIIIC35) (Transcription factor IIIC subunit 6) Gtf3c6 Mus musculus (Mouse) 227 "transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase III promoter [GO:0006383]" GO:0000127; GO:0003677; GO:0006351; GO:0006383 0 0 0 PF10419; Q9JJA7 CHOYP_LOC100366728.1.1 m.57451 sp CCNL2_MOUSE 46.739 184 84 3 17 187 219 401 4.52E-37 140 CCNL2_MOUSE reviewed Cyclin-L2 (Cyclin Ania-6b) (Paneth cell-enhanced expression protein) (PCEE) Ccnl2 Ania6b MNCb-5160 Mus musculus (Mouse) 518 "positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of phosphorylation of RNA polymerase II C-terminal domain [GO:1901409]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000307; GO:0005634; GO:0005654; GO:0006351; GO:0016538; GO:0016607; GO:0043231; GO:0045737; GO:0045944; GO:1901409 0 0 0 PF02984;PF00134; Q9UMZ3 CHOYP_PTPRQ.7.8 m.59832 sp PTPRQ_HUMAN 28.281 442 259 19 129 534 1884 2303 4.52E-33 138 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; E7FCN8 CHOYP_INTU.3.3 m.36015 sp INTU_DANRE 28.764 963 563 25 54 979 36 912 4.53E-107 357 INTU_DANRE reviewed Protein inturned (Inturned planar cell polarity effector homolog) intu Danio rerio (Zebrafish) (Brachydanio rerio) 915 cilium assembly [GO:0042384]; limb development [GO:0060173]; nervous system development [GO:0007399]; regulation of smoothened signaling pathway [GO:0008589] GO:0005737; GO:0007399; GO:0008589; GO:0009986; GO:0042384; GO:0060173 0 0 0 0 I3LM39 CHOYP_CGAS.6.6 m.59477 sp CGAS_PIG 22.4 375 219 11 18 363 143 474 4.53E-11 68.6 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O96790 CHOYP_RCOM_1886900.1.1 m.11248 sp DPGN_DIPMA 36.559 93 40 3 18 91 179 271 4.53E-08 52.4 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P00491 CHOYP_PNP5B.1.1 m.21997 sp PNPH_HUMAN 51.786 280 135 0 84 363 3 282 4.53E-106 316 PNPH_HUMAN reviewed Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) PNP NP Homo sapiens (Human) 289 immune response [GO:0006955]; inosine catabolic process [GO:0006148]; interleukin-2 secretion [GO:0070970]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of T cell proliferation [GO:0042102]; purine-containing compound salvage [GO:0043101]; purine nucleotide catabolic process [GO:0006195]; response to drug [GO:0042493]; urate biosynthetic process [GO:0034418] GO:0001882; GO:0002060; GO:0004731; GO:0005622; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0006139; GO:0006148; GO:0006195; GO:0006738; GO:0006955; GO:0008144; GO:0034356; GO:0034418; GO:0042102; GO:0042301; GO:0042493; GO:0043101; GO:0046638; GO:0070062; GO:0070970 PATHWAY: Purine metabolism; purine nucleoside salvage. 0 0 PF01048; P01130 CHOYP_H2B.2.2 m.65141 sp LDLR_HUMAN 59.091 66 26 1 40 104 80 145 4.53E-19 84 LDLR_HUMAN reviewed Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899] GO:0001618; GO:0001948; GO:0002020; GO:0004872; GO:0005041; GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005887; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0008203; GO:0009897; GO:0009986; GO:0010008; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0030669; GO:0032050; GO:0034362; GO:0034383; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0070508; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P10079 CHOYP_LOC100634060.6.37 m.17813 sp FBP1_STRPU 55.522 335 149 0 3 337 205 539 4.53E-113 355 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P24044 CHOYP_CENTRIN.1.1 m.59526 sp CALM_PLAFA 26.241 141 101 1 230 367 4 144 4.53E-10 60.8 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; Q0P5B7 CHOYP_AAAD.2.4 m.28999 sp AAAD_BOVIN 36.16 401 241 10 10 403 7 399 4.53E-70 229 AAAD_BOVIN reviewed Arylacetamide deacetylase (EC 3.1.1.3) AADAC Bos taurus (Bovine) 399 metabolic process [GO:0008152]; positive regulation of triglyceride catabolic process [GO:0010898] GO:0004806; GO:0005789; GO:0008152; GO:0010898; GO:0016021; GO:0017171; GO:0031090 0 0 0 PF07859; Q0VH32 CHOYP_LOC100146233.1.1 m.36400 sp MNT_XENLA 62.295 122 44 1 59 178 216 337 4.53E-42 163 MNT_XENLA reviewed Max-binding protein MNT (Myc antagonist MNT) mnt Xenopus laevis (African clawed frog) 574 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF00010; Q14686 CHOYP_contig_045662 m.53210 sp NCOA6_HUMAN 43.689 103 57 1 10 111 47 149 4.53E-19 98.6 NCOA6_HUMAN reviewed "Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)" NCOA6 AIB3 KIAA0181 RAP250 TRBP Homo sapiens (Human) 2063 "brain development [GO:0007420]; cellular lipid metabolic process [GO:0044255]; cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-templated transcription, initiation [GO:0006352]; glucocorticoid receptor signaling pathway [GO:0042921]; heart development [GO:0007507]; intracellular estrogen receptor signaling pathway [GO:0030520]; myeloid cell differentiation [GO:0030099]; ovarian follicle development [GO:0001541]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to hormone [GO:0009725]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001541; GO:0003682; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0006260; GO:0006281; GO:0006310; GO:0006352; GO:0006367; GO:0006974; GO:0007420; GO:0007507; GO:0009725; GO:0019899; GO:0030099; GO:0030331; GO:0030374; GO:0030520; GO:0035097; GO:0035774; GO:0042921; GO:0043231; GO:0044255; GO:0045893; GO:0045944; GO:0046965; GO:0046966 0 0 0 PF13820; Q26636 CHOYP_LOC575203.5.6 m.19653 sp CATL_SARPE 49.407 253 121 3 42 287 25 277 4.53E-84 258 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q5PQP2 CHOYP_LOC100644701.2.2 m.54960 sp RCAS1_RAT 36.279 215 109 11 11 208 10 213 4.53E-28 108 RCAS1_RAT reviewed Receptor-binding cancer antigen expressed on SiSo cells (Estrogen receptor-binding fragment-associated gene 9 protein) Ebag9 Rattus norvegicus (Rat) 213 apoptotic process [GO:0006915] GO:0000139; GO:0006915; GO:0016021; GO:0030141 0 0 0 0 Q6P1X6 CHOYP_LOC579016.1.1 m.30390 sp CH082_HUMAN 54.645 183 83 0 26 208 28 210 4.53E-75 228 CH082_HUMAN reviewed UPF0598 protein C8orf82 C8orf82 Homo sapiens (Human) 216 0 0 0 0 0 PF14956; Q7LL04 CHOYP_LOC752472.1.1 m.37316 sp YQK1_SCHPO 36.576 257 144 8 31 276 3 251 4.53E-34 129 YQK1_SCHPO reviewed UPF0676 protein C1494.01 SPCC1494.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 321 0 GO:0005634; GO:0005737; GO:0005829; GO:0051213 0 0 0 PF03171;PF14226; Q80W68 CHOYP_LOC100869743.1.1 m.1219 sp KIRR1_MOUSE 26.293 232 147 8 23 254 36 243 4.53E-09 60.8 KIRR1_MOUSE reviewed Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) Kirrel Kirrel1 Neph1 Mus musculus (Mouse) 789 excretion [GO:0007588]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of actin filament polymerization [GO:0030838]; single organismal cell-cell adhesion [GO:0016337] GO:0001933; GO:0005886; GO:0005911; GO:0007588; GO:0016021; GO:0016337; GO:0017022; GO:0030838; GO:0031253; GO:0043198; GO:0045121; GO:0048471; GO:0070062 0 0 0 PF08205;PF07679; Q8BMI3 CHOYP_F179B.1.1 m.45817 sp GGA3_MOUSE 44.37 746 311 24 1614 2294 3 709 4.53E-157 507 GGA3_MOUSE reviewed "ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)" Gga3 Kiaa0154 Mus musculus (Mouse) 718 intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; vesicle-mediated transport [GO:0016192] GO:0005802; GO:0006886; GO:0010008; GO:0016192; GO:0030131; GO:0030306; GO:0045732 0 0 0 PF02883;PF03127;PF00790; Q8NHP6 CHOYP_LOC100373427.1.1 m.49648 sp MSPD2_HUMAN 33.659 511 296 12 41 524 1 495 4.53E-88 285 MSPD2_HUMAN reviewed Motile sperm domain-containing protein 2 MOSPD2 Homo sapiens (Human) 518 0 GO:0016020; GO:0016021 0 0 0 PF00650;PF00635; Q9CYL5 CHOYP_ISCW_ISCW019177.2.4 m.56600 sp GAPR1_MOUSE 44.937 158 78 5 92 246 2 153 4.53E-35 125 GAPR1_MOUSE reviewed Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) Glipr2 Gapr1 Mus musculus (Mouse) 154 positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374 0 0 0 PF00188; Q9DBV3 CHOYP_NEMVEDRAFT_V1G241791.2.2 m.6919 sp DHX34_MOUSE 35.669 157 92 3 125 280 30 178 4.53E-22 99.4 DHX34_MOUSE reviewed Probable ATP-dependent RNA helicase DHX34 (EC 3.6.4.13) (DEAH box protein 34) Dhx34 Ddx34 Kiaa0134 Mus musculus (Mouse) 1145 "negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; RNA processing [GO:0006396]" GO:0000956; GO:0004004; GO:0005524; GO:0005634; GO:0005739; GO:0006396; GO:0016020; GO:0044822; GO:2000623 0 0 0 PF00270;PF04408;PF00271;PF07717; Q9NRL2 CHOYP_LOC100120677.1.1 m.16798 sp BAZ1A_HUMAN 34.16 524 218 14 196 690 773 1198 4.53E-69 256 BAZ1A_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) BAZ1A ACF1 WCRF180 HSPC317 Homo sapiens (Human) 1556 "chromatin remodeling [GO:0006338]; DNA-dependent DNA replication [GO:0006261]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006261; GO:0006338; GO:0006351; GO:0006355; GO:0008270; GO:0008623; GO:0016590 0 0 0 PF00439;PF02791;PF00628;PF10537;PF15612;PF15613; Q9VY28 CHOYP_LOC100375481.1.1 m.4496 sp RT25_DROME 37.278 169 96 2 1 167 1 161 4.53E-34 121 RT25_DROME reviewed "Probable 28S ribosomal protein S25, mitochondrial (MRP-S25) (S25mt)" mRpS25 CG14413 Drosophila melanogaster (Fruit fly) 167 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005763; GO:0006412 0 0 0 PF05047; B6CZ61 CHOYP_BRAFLDRAFT_123291.1.1 m.11923 sp LRC51_RAT 49.153 177 89 1 29 205 15 190 4.54E-58 184 LRC51_RAT reviewed Leucine-rich repeat-containing protein 51 (Protein LRTOMT1) Lrrc51 Lrtomt1 Rattus norvegicus (Rat) 192 0 GO:0005737 0 0 0 0 G5ED84 CHOYP_LOC100533258.2.6 m.9901 sp KLHL8_CAEEL 26.875 160 105 4 10 158 88 246 4.54E-09 63.5 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O70511 CHOYP_TVAG_291510.7.9 m.38367 sp ANK3_RAT 25.241 622 408 15 950 1548 237 824 4.54E-38 160 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O75489 CHOYP_ISCW_ISCW012366.1.1 m.3691 sp NDUS3_HUMAN 55.814 258 100 3 15 269 14 260 4.54E-102 301 NDUS3_HUMAN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)" NDUFS3 Homo sapiens (Human) 264 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]; negative regulation of cell growth [GO:0030308]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; reactive oxygen species metabolic process [GO:0072593]; substantia nigra development [GO:0021762]" GO:0003954; GO:0005634; GO:0005739; GO:0005747; GO:0005759; GO:0006120; GO:0008137; GO:0009055; GO:0021762; GO:0030308; GO:0031966; GO:0032981; GO:0043209; GO:0072593; GO:2001243 0 0 0 PF00329; O97772 CHOYP_CCKAR.2.6 m.31361 sp CCKAR_RABIT 33.628 113 71 4 2 112 37 147 4.54E-10 64.3 CCKAR_RABIT reviewed Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Oryctolagus cuniculus (Rabbit) 427 0 GO:0004951; GO:0005886; GO:0016021 0 0 0 PF00001;PF09193; P02637 CHOYP_CYIIB.2.2 m.64544 sp SCP_MIZYE 63.068 176 62 3 2 176 2 175 4.54E-75 225 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P17210 CHOYP_AAEL_AAEL008542.1.1 m.13258 sp KINH_DROME 83.824 68 11 0 56 123 845 912 4.54E-30 116 KINH_DROME reviewed Kinesin heavy chain Khc kin CG7765 Drosophila melanogaster (Fruit fly) 975 "actin filament bundle organization [GO:0061572]; axo-dendritic transport [GO:0008088]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; centrosome separation [GO:0051299]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; dendrite morphogenesis [GO:0048813]; dorsal appendage formation [GO:0046843]; establishment of localization by movement along microtubule [GO:0010970]; establishment of nucleus localization [GO:0040023]; eye photoreceptor cell differentiation [GO:0001754]; intracellular distribution of mitochondria [GO:0048312]; intracellular protein transport [GO:0006886]; larval locomotory behavior [GO:0008345]; maintenance of cell polarity [GO:0030011]; microtubule-based movement [GO:0007018]; microtubule polymerization [GO:0046785]; microtubule sliding [GO:0051012]; mitochondrion distribution [GO:0048311]; mitochondrion transport along microtubule [GO:0047497]; neuron projection morphogenesis [GO:0048812]; oocyte dorsal/ventral axis specification [GO:0007310]; oocyte microtubule cytoskeleton polarization [GO:0008103]; pole plasm assembly [GO:0007315]; pole plasm oskar mRNA localization [GO:0045451]; regulation of pole plasm oskar mRNA localization [GO:0007317]; skeletal muscle fiber development [GO:0048741]; stress granule disassembly [GO:0035617]" GO:0001754; GO:0003774; GO:0003777; GO:0005524; GO:0005737; GO:0005829; GO:0005871; GO:0005875; GO:0006886; GO:0007018; GO:0007303; GO:0007310; GO:0007315; GO:0007317; GO:0007409; GO:0007411; GO:0008017; GO:0008088; GO:0008103; GO:0008345; GO:0008574; GO:0010970; GO:0030011; GO:0030478; GO:0035371; GO:0035617; GO:0040023; GO:0043005; GO:0045451; GO:0046785; GO:0046843; GO:0047497; GO:0048311; GO:0048312; GO:0048741; GO:0048812; GO:0048813; GO:0051012; GO:0051299; GO:0061572 0 0 0 PF00225; P20825 CHOYP_contig_024958 m.28403 sp POL2_DROME 33.21 810 477 18 635 1423 193 959 4.54E-117 400 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P42026 CHOYP_LOC732995.2.2 m.36885 sp NDUS7_BOVIN 58.871 124 42 2 10 133 25 139 4.54E-45 149 NDUS7_BOVIN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) 216 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005747; GO:0008137; GO:0032981; GO:0046872; GO:0048038; GO:0051539 0 0 0 PF01058; P53370 CHOYP_LOC101071822.1.1 m.171 sp NUDT6_HUMAN 49.618 262 128 2 60 318 51 311 4.54E-91 277 NUDT6_HUMAN reviewed Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (EC 3.6.1.-) (Antisense basic fibroblast growth factor) (Protein GFG) NUDT6 FGF2AS Homo sapiens (Human) 316 0 GO:0005634; GO:0005739; GO:0008083; GO:0016787 0 0 0 PF00293; Q03412 CHOYP_LOC100533354.5.6 m.61992 sp UNC7_CAEEL 35.676 370 225 5 29 394 138 498 4.54E-79 257 UNC7_CAEEL reviewed Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans 522 gap junction assembly [GO:0016264]; ion transmembrane transport [GO:0034220]; locomotion [GO:0040011]; oviposition [GO:0018991]; regulation of pharyngeal pumping [GO:0043051]; response to anesthetic [GO:0072347] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0016264; GO:0018991; GO:0032589; GO:0034220; GO:0040011; GO:0043051; GO:0055077; GO:0072347 0 0 0 PF00876; Q09139 CHOYP_LOC100882621.2.2 m.40308 sp FABP7_BOVIN 32.353 136 87 3 4 139 2 132 4.54E-15 70.1 FABP7_BOVIN reviewed "Fatty acid-binding protein, brain (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7)" FABP7 Bos taurus (Bovine) 132 cell proliferation in forebrain [GO:0021846]; neurogenesis [GO:0022008]; prepulse inhibition [GO:0060134] GO:0005215; GO:0005654; GO:0005737; GO:0005911; GO:0008289; GO:0021846; GO:0022008; GO:0042995; GO:0043025; GO:0060134; GO:0071944 0 0 0 PF00061; Q14980 CHOYP_TVAG_110290.4.8 m.11895 sp NUMA1_HUMAN 23.876 645 310 29 1741 2281 1490 2057 4.54E-11 72.8 NUMA1_HUMAN reviewed Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) 2115 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997] GO:0000132; GO:0000139; GO:0000922; GO:0005198; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005876; GO:0005938; GO:0006997; GO:0007067; GO:0016363; GO:0030425; GO:0043025; GO:0045177; GO:0051301; GO:0051321; GO:0060487; GO:0061673; GO:0070062; GO:0072686; GO:0097431 0 0 0 0 Q19QU3 CHOYP_BRAFLDRAFT_150340.2.4 m.13895 sp ZRAB2_PIG 58.621 145 37 3 21 165 6 127 4.54E-51 174 ZRAB2_PIG reviewed Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) ZRANB2 ZNF265 Sus scrofa (Pig) 328 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0006397; GO:0008270; GO:0008380; GO:0044822 0 0 0 PF00641; Q3SZL5 CHOYP_PIGS.1.1 m.18958 sp PIGS_BOVIN 40.107 561 280 15 18 546 19 555 4.54E-107 334 PIGS_BOVIN reviewed GPI transamidase component PIG-S (Phosphatidylinositol-glycan biosynthesis class S protein) PIGS Bos taurus (Bovine) 555 attachment of GPI anchor to protein [GO:0016255] GO:0016255; GO:0042765 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF10510; Q3T139 CHOYP_ND5.2.6 m.12505 sp R146B_BOVIN 47.964 221 109 2 13 233 20 234 4.54E-68 219 R146B_BOVIN reviewed E3 ubiquitin-protein ligase RNF146-B (EC 6.3.2.-) (RING finger protein 146-B) RNF146B Bos taurus (Bovine) 347 positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005829; GO:0008270; GO:0016055; GO:0016874; GO:0042787; GO:0051865; GO:0061630; GO:0070936; GO:0072572; GO:0090263 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02825; Q4UMH6 CHOYP_PNO1.3.3 m.61366 sp Y381_RICFE 25.185 270 195 4 1068 1336 865 1128 4.54E-23 110 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q4UMH6 CHOYP_TVAG_499360.1.1 m.59835 sp Y381_RICFE 30.741 270 152 10 38 306 869 1104 4.54E-15 80.1 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q502M6 CHOYP_LOC100638992.1.2 m.61130 sp ANR29_DANRE 40.136 147 88 0 1 147 54 200 4.54E-30 113 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q8CB62 CHOYP_CNTROB.1.1 m.11584 sp CNTRB_MOUSE 30.39 487 322 5 535 1021 97 566 4.54E-62 233 CNTRB_MOUSE reviewed Centrobin (Centrosomal BRCA2-interacting protein) (LYST-interacting protein 8) Cntrob Lip8 Mus musculus (Mouse) 887 centriole replication [GO:0007099]; centrosome separation [GO:0051299]; mitotic cytokinetic process [GO:1902410] GO:0005737; GO:0005813; GO:0005814; GO:0007099; GO:0019904; GO:0051299; GO:1902410 0 0 0 0 Q8K2R5 CHOYP_BRAFLDRAFT_96471.1.1 m.1012 sp ZN668_MOUSE 25.952 420 242 16 116 491 1 395 4.54E-24 110 ZN668_MOUSE reviewed Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q8WQI5 CHOYP_NPL4.1.1 m.62115 sp RS8_SPOFR 71.905 210 57 1 6 215 1 208 4.54E-108 311 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q9UBQ7 CHOYP_LOC100375265.1.2 m.936 sp GRHPR_HUMAN 34.471 293 170 7 6 284 8 292 4.54E-48 167 GRHPR_HUMAN reviewed Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) 328 dicarboxylic acid metabolic process [GO:0043648]; excretion [GO:0007588]; glyoxylate metabolic process [GO:0046487]; metabolic process [GO:0008152]; oxidation-reduction process [GO:0055114]; protein oligomerization [GO:0051259] GO:0005737; GO:0005782; GO:0005829; GO:0007588; GO:0008152; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051259; GO:0051287; GO:0055114; GO:0070062; GO:0070402 0 0 0 PF00389;PF02826; Q9VUL9 CHOYP_DWIL_GK20401.1.1 m.51877 sp FUCTA_DROME 53.425 365 157 8 82 442 142 497 4.54E-126 378 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; O43818 CHOYP_LOC100376387.1.1 m.9565 sp U3IP2_HUMAN 54.015 411 187 1 57 467 61 469 4.55E-163 472 U3IP2_HUMAN reviewed U3 small nucleolar RNA-interacting protein 2 (RRP9 homolog) (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K) RRP9 RNU3IP2 U355K Homo sapiens (Human) 475 rRNA processing [GO:0006364] GO:0005634; GO:0005654; GO:0005730; GO:0006364; GO:0031428; GO:0032040; GO:0044822 0 0 0 PF00400; P16157 CHOYP_ANK2.6.8 m.52795 sp ANK1_HUMAN 34.504 484 310 1 2 478 303 786 4.55E-71 250 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q13546 CHOYP_BRAFLDRAFT_80064.1.1 m.40175 sp RIPK1_HUMAN 33.071 127 77 3 62 180 539 665 4.55E-11 63.9 RIPK1_HUMAN reviewed Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1) (Serine/threonine-protein kinase RIP) RIPK1 RIP RIP1 Homo sapiens (Human) 671 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; activation of JUN kinase activity [GO:0007257]; amyloid fibril formation [GO:1990000]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular protein catabolic process [GO:0044257]; cellular response to growth factor stimulus [GO:0071363]; cellular response to tumor necrosis factor [GO:0071356]; death-inducing signaling complex assembly [GO:0071550]; extrinsic apoptotic signaling pathway [GO:0097191]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; peptidyl-serine autophosphorylation [GO:0036289]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of hydrogen peroxide-induced cell death [GO:1905206]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of necroptotic process [GO:0060545]; positive regulation of necrotic cell death [GO:0010940]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein autophosphorylation [GO:0046777]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; regulation of ATP:ADP antiporter activity [GO:0070926]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of necrotic cell death [GO:0010939]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to tumor necrosis factor [GO:0034612]; ripoptosome assembly [GO:0097343]; ripoptosome assembly involved in necroptotic process [GO:1901026]; T cell apoptotic process [GO:0070231]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001934; GO:0004672; GO:0004674; GO:0005123; GO:0005524; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0006919; GO:0007249; GO:0007257; GO:0010803; GO:0010939; GO:0010940; GO:0031264; GO:0031625; GO:0032403; GO:0032757; GO:0032760; GO:0033209; GO:0034612; GO:0035666; GO:0036289; GO:0042802; GO:0043065; GO:0043068; GO:0043123; GO:0043124; GO:0043235; GO:0044257; GO:0045121; GO:0045651; GO:0045944; GO:0046330; GO:0046777; GO:0051092; GO:0051260; GO:0051291; GO:0060545; GO:0070231; GO:0070266; GO:0070513; GO:0070926; GO:0071356; GO:0071363; GO:0071550; GO:0097190; GO:0097191; GO:0097296; GO:0097342; GO:0097343; GO:0097527; GO:1901026; GO:1902041; GO:1902042; GO:1905206; GO:1990000; GO:2000379; GO:2001237; GO:2001238; GO:2001240 0 0 0 PF00531;PF07714;PF12721; Q1PRL4 CHOYP_RN207.2.5 m.32649 sp LIN41_CHICK 22.267 247 142 9 5 218 197 426 4.55E-09 59.7 LIN41_CHICK reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) 876 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q2KIN4 CHOYP_HEY-LIKE.1.1 m.11131 sp HEY1_BOVIN 46.575 292 123 6 63 345 35 302 4.55E-70 224 HEY1_BOVIN reviewed Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Bos taurus (Bovine) 304 "angiogenesis [GO:0001525]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [GO:2000820]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; Notch signaling pathway [GO:0007219]; transcription, DNA-templated [GO:0006351]" GO:0000988; GO:0001525; GO:0003198; GO:0003700; GO:0005634; GO:0006351; GO:0007219; GO:0035939; GO:0045746; GO:2000678; GO:2000820 0 0 0 PF07527;PF00010; Q4KLI9 CHOYP_ISCW_ISCW008293.2.5 m.32053 sp FBXW5_RAT 28.019 207 138 5 2 200 3 206 4.55E-14 78.2 FBXW5_RAT reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) 569 centrosome duplication [GO:0051298]; mitotic nuclear division [GO:0007067]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000151; GO:0005737; GO:0007067; GO:0010824; GO:0016567; GO:0019005; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q5BJW3 CHOYP_BRAFLDRAFT_213467.1.1 m.34929 sp TX261_RAT 55.5 200 81 2 1 198 1 194 4.55E-75 227 TX261_RAT reviewed Protein TEX261 Tex261 Rattus norvegicus (Rat) 196 ER to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of apoptotic process [GO:0043065] GO:0006888; GO:0030134; GO:0030173; GO:0030176; GO:0043065; GO:0097020 0 0 0 PF04148; Q5XK92 CHOYP_LOC591924.1.1 m.13292 sp CIP2A_XENLA 32.682 921 589 12 4 918 1 896 4.55E-163 503 CIP2A_XENLA reviewed Protein CIP2A homolog 0 Xenopus laevis (African clawed frog) 906 0 GO:0005737; GO:0016021 0 0 0 0 Q5ZIW1 CHOYP_LOC100551924.1.1 m.31476 sp PEO1_CHICK 57.762 277 116 1 1 277 360 635 4.55E-112 342 PEO1_CHICK reviewed "Twinkle protein, mitochondrial (EC 3.6.4.12) (Progressive external ophthalmoplegia 1 protein homolog)" PEO1 RCJMB04_23c24 Gallus gallus (Chicken) 669 mitochondrial DNA replication [GO:0006264] GO:0003697; GO:0005524; GO:0006264; GO:0042645; GO:0043139 0 0 0 0 Q6DFC8 CHOYP_LOC100161599.1.1 m.27382 sp ZN395_XENLA 32.477 545 282 26 4 514 6 498 4.55E-54 192 ZN395_XENLA reviewed Zinc finger protein 395 znf395 Xenopus laevis (African clawed frog) 498 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF15997; Q6PDJ6 CHOYP_FBX42.1.1 m.11569 sp FBX42_MOUSE 50.779 321 151 4 23 338 47 365 4.55E-113 357 FBX42_MOUSE reviewed F-box only protein 42 Fbxo42 Mus musculus (Mouse) 717 0 0 0 0 0 PF12937;PF07646; Q6Q899 CHOYP_DDX58.7.9 m.58168 sp DDX58_MOUSE 30.495 728 449 20 401 1099 212 911 4.55E-82 291 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6ZRF8 CHOYP_LOC100378676.6.8 m.60893 sp RN207_HUMAN 21.359 206 142 7 23 219 100 294 4.55E-09 62.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7Z0T3 CHOYP_TRIADDRAFT_32712.1.4 m.6951 sp TEMPT_APLCA 49.541 109 52 3 6 112 13 120 4.55E-27 100 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q8C156 CHOYP_BRAFLDRAFT_124950.1.1 m.8139 sp CND2_MOUSE 36.774 775 379 25 2 741 32 730 4.55E-125 393 CND2_MOUSE reviewed Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (mCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) Ncaph Brrn Brrn1 Caph Mus musculus (Mouse) 731 cell division [GO:0051301]; mitotic chromosome condensation [GO:0007076] GO:0000796; GO:0005634; GO:0005737; GO:0007076; GO:0016020; GO:0051301 0 0 0 PF05786; Q8N1H7 CHOYP_LOC576619.1.1 m.48425 sp S6OS1_HUMAN 24.306 144 109 0 50 193 9 152 4.55E-06 53.9 S6OS1_HUMAN reviewed Protein SIX6OS1 (Six6 opposite strand transcript 1) SIX6OS1 C14orf39 Homo sapiens (Human) 587 multicellular organism development [GO:0007275]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090] GO:0007275; GO:0051090 0 0 0 PF15676; Q96P09 CHOYP_BRAFLDRAFT_284264.1.1 m.45717 sp BIRC8_HUMAN 45 60 33 0 263 322 22 81 4.55E-11 65.9 BIRC8_HUMAN reviewed Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis) BIRC8 ILP2 Homo sapiens (Human) 236 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; positive regulation of canonical Wnt signaling pathway [GO:0090263] GO:0004842; GO:0005634; GO:0005737; GO:0008270; GO:0043027; GO:0090263; GO:1990001 0 0 0 PF00653; Q9BSD7 CHOYP_NTPCR.1.1 m.33643 sp NTPCR_HUMAN 55.497 191 77 3 11 199 3 187 4.55E-63 196 NTPCR_HUMAN reviewed Cancer-related nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) (Nucleoside triphosphate phosphohydrolase) NTPCR C1orf57 Homo sapiens (Human) 190 0 GO:0005524; GO:0016020; GO:0017111; GO:0044822; GO:0070062; GO:0098519 0 0 0 PF03266; Q9NUV9 CHOYP_LOC100694349.1.1 m.52363 sp GIMA4_HUMAN 33.476 233 137 5 333 555 27 251 4.55E-34 135 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9TWL9 CHOYP_NEMVEDRAFT_V1G220308.1.2 m.3021 sp COMA_CONMA 43.396 53 30 0 58 110 14 66 4.55E-10 56.2 COMA_CONMA reviewed Conodipine-M alpha chain (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) 0 Conus magus (Magus cone) (Magician's cone snail) 77 lipid catabolic process [GO:0016042] GO:0004623; GO:0005576; GO:0016042 0 0 0 0 Q9Y619 CHOYP_ISCW_ISCW003704.1.1 m.6942 sp ORNT1_HUMAN 50.993 302 141 4 28 329 2 296 4.55E-98 295 ORNT1_HUMAN reviewed Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15) SLC25A15 ORNT1 SP1855 Homo sapiens (Human) 301 cellular amino acid metabolic process [GO:0006520]; mitochondrial ornithine transport [GO:0000066]; translation [GO:0006412]; urea cycle [GO:0000050] GO:0000050; GO:0000064; GO:0000066; GO:0003735; GO:0005743; GO:0006412; GO:0006520; GO:0016021 0 0 0 PF00153; A0JNB1 CHOYP_ZN227.1.3 m.13733 sp ZN227_BOVIN 40.757 449 244 6 16 444 313 759 4.56E-96 309 ZN227_BOVIN reviewed Zinc finger protein 227 ZNF227 Bos taurus (Bovine) 787 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; A2AX52 CHOYP_LOC100486063.3.9 m.14689 sp CO6A4_MOUSE 34.091 88 54 1 58 145 1016 1099 4.56E-10 60.1 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; A4IF63 CHOYP_BRAFLDRAFT_63298.4.6 m.32575 sp TRIM2_BOVIN 30.864 81 56 0 76 156 627 707 4.56E-07 51.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IFB6 CHOYP_BRAFLDRAFT_118793.1.1 m.20795 sp CNO10_BOVIN 41.477 704 373 10 1 665 1 704 4.56E-178 528 CNO10_BOVIN reviewed CCR4-NOT transcription complex subunit 10 CNOT10 Bos taurus (Bovine) 743 0 GO:0016020; GO:0030014 0 0 0 0 E7FAM5 CHOYP_BRAFLDRAFT_79377.26.30 m.60173 sp LIN41_DANRE 31.624 117 75 1 69 180 565 681 4.56E-08 55.5 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; E9PVX6 CHOYP_LOC100371881.1.2 m.3634 sp KI67_MOUSE 49.541 109 55 0 6 114 7 115 4.56E-29 131 KI67_MOUSE reviewed Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67 homolog) (Antigen KI-67 homolog) (Antigen Ki67 homolog) Mki67 Mus musculus (Mouse) 3177 cell proliferation [GO:0008283]; cellular response to heat [GO:0034605]; cholangiocyte proliferation [GO:1990705]; DNA metabolic process [GO:0006259]; hepatocyte proliferation [GO:0072574]; hyaluronan metabolic process [GO:0030212]; meiotic nuclear division [GO:0007126]; organ regeneration [GO:0031100]; response to organic cyclic compound [GO:0014070] GO:0000775; GO:0000793; GO:0005634; GO:0005730; GO:0005737; GO:0006259; GO:0007126; GO:0008022; GO:0008283; GO:0014070; GO:0016020; GO:0030212; GO:0031100; GO:0034605; GO:0044822; GO:0072574; GO:1990705 0 0 0 PF00498;PF08065;PF15276; O42387 CHOYP_GPSM2.1.1 m.58302 sp RS24_TAKRU 81.25 128 24 0 5 132 4 131 4.56E-73 217 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; P16157 CHOYP_LOC755521.15.28 m.42726 sp ANK1_HUMAN 36.624 314 197 1 8 321 220 531 4.56E-56 201 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P42577 CHOYP_LOC100371268.2.2 m.42524 sp FRIS_LYMST 78.151 119 26 0 1 119 35 153 4.56E-66 200 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; Q08890 CHOYP_LOC100185385.1.1 m.18276 sp IDS_MOUSE 48.842 518 249 4 31 539 40 550 4.56E-180 521 IDS_MOUSE reviewed Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) Ids Mus musculus (Mouse) 552 metabolic process [GO:0008152] GO:0004423; GO:0005764; GO:0008152; GO:0008484; GO:0046872 0 0 0 PF00884; Q5E9J9 CHOYP_STRAA.1.1 m.66699 sp STRAA_BOVIN 44.474 371 188 5 54 409 6 373 4.56E-104 315 STRAA_BOVIN reviewed STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) STRADA LYK5 STRAD Bos taurus (Bovine) 373 activation of protein kinase activity [GO:0032147]; cell cycle [GO:0007049]; protein export from nucleus [GO:0006611] GO:0004672; GO:0005524; GO:0005634; GO:0005737; GO:0006611; GO:0007049; GO:0030295; GO:0032147 0 0 0 PF00069; Q66II5 CHOYP_T3HPD.2.2 m.59050 sp T3HPD_XENTR 50.442 339 166 2 2 339 11 348 4.56E-126 368 T3HPD_XENTR reviewed Trans-L-3-hydroxyproline dehydratase (EC 4.2.1.77) (Trans-3-hydroxy-L-proline dehydratase) l3hypdh Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 348 metabolic process [GO:0008152] GO:0008152; GO:0016836; GO:0050346 0 0 0 PF05544; Q6UPE0 CHOYP_LOC661056.1.1 m.63205 sp CHDH_RAT 50.962 104 50 1 3 105 213 316 4.56E-30 115 CHDH_RAT reviewed "Choline dehydrogenase, mitochondrial (CDH) (CHD) (EC 1.1.99.1)" Chdh Rattus norvegicus (Rat) 599 glycine betaine biosynthetic process from choline [GO:0019285] GO:0005743; GO:0008812; GO:0019285; GO:0050660 PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. 0 0 PF05199;PF00732; Q6XIM8 CHOYP_RS15A.1.11 m.1703 sp RS15A_DROYA 85.321 109 16 0 1 109 1 109 4.56E-63 209 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q6ZQ12 CHOYP_LOC100033222.1.1 m.35407 sp NINL_MOUSE 30.919 566 310 17 169 718 99 599 4.56E-56 218 NINL_MOUSE reviewed Ninein-like protein Ninl Kiaa0980 Nlp Mus musculus (Mouse) 1394 microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005509; GO:0005737; GO:0005815; GO:0005856; GO:0005874 0 0 0 PF13499; Q8JIV8 CHOYP_SL.1.1 m.29308 sp SL_DEIAC 30.822 146 73 7 143 274 16 147 4.56E-09 57.4 SL_DEIAC reviewed Snaclec clone 2100755 (C-type lectin clone 2100755) 0 Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus) 155 0 GO:0005576 0 0 0 PF00059; Q8WZ42 CHOYP_TITIN.18.19 m.65497 sp TITIN_HUMAN 30.271 1622 929 42 1774 3313 942 2443 4.56E-173 610 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q9DAK2 CHOYP_BRAFLDRAFT_99083.1.1 m.11705 sp PACRG_MOUSE 81.532 222 39 1 22 243 22 241 4.56E-136 385 PACRG_MOUSE reviewed Parkin coregulated gene protein homolog (Hypertension-related protein 1-like protein) (PARK2 coregulated gene protein) Pacrg Mus musculus (Mouse) 241 cellular response to unfolded protein [GO:0034620]; negative regulation of cell death [GO:0060548]; spermatid development [GO:0007286] GO:0001664; GO:0003779; GO:0005634; GO:0005739; GO:0005829; GO:0005929; GO:0007286; GO:0030544; GO:0031072; GO:0031625; GO:0031982; GO:0034620; GO:0043005; GO:0043014; GO:0044297; GO:0048487; GO:0051087; GO:0051879; GO:0060548; GO:0097225 0 0 0 PF10274; Q9I925 CHOYP_BRAFLDRAFT_83012.2.2 m.61619 sp FUCL7_ANGJA 24.551 167 107 6 5 156 21 183 4.56E-06 47.8 FUCL7_ANGJA reviewed Fucolectin-7 0 Anguilla japonica (Japanese eel) 189 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9MZ34 CHOYP_S6A11.1.1 m.58011 sp SC6A6_BOVIN 41.346 104 58 1 19 122 482 582 4.56E-19 87 SC6A6_BOVIN reviewed Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6) SLC6A6 Bos taurus (Bovine) 620 amino acid transmembrane transport [GO:0003333]; taurine transport [GO:0015734] GO:0003333; GO:0005328; GO:0005369; GO:0005887; GO:0015734 0 0 0 PF00209; Q9NQG7 CHOYP_BRAFLDRAFT_84245.2.2 m.53621 sp HPS4_HUMAN 26.648 349 214 8 16 338 18 350 4.56E-21 100 HPS4_HUMAN reviewed Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog) HPS4 KIAA1667 Homo sapiens (Human) 708 blood coagulation [GO:0007596]; hemostasis [GO:0007599]; lysosome organization [GO:0007040]; melanocyte differentiation [GO:0030318]; positive regulation of eye pigmentation [GO:0048075]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein stabilization [GO:0050821]; protein targeting [GO:0006605] GO:0005737; GO:0005764; GO:0006605; GO:0007040; GO:0007596; GO:0007599; GO:0016020; GO:0030318; GO:0031085; GO:0042470; GO:0042803; GO:0042827; GO:0046983; GO:0048075; GO:0050821; GO:1903955 0 0 0 0 Q9XSC1 CHOYP_LOC100533444.1.1 m.33578 sp SFRP5_BOVIN 43.6 250 132 6 43 285 49 296 4.56E-66 229 SFRP5_BOVIN reviewed Secreted frizzled-related protein 5 (sFRP-5) SFRP5 Bos taurus (Bovine) 315 canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catenin import into nucleus [GO:0035414]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of Wnt signaling pathway [GO:0030178]; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis [GO:2000057]; non-canonical Wnt signaling pathway [GO:0035567] GO:0004930; GO:0005576; GO:0007275; GO:0008285; GO:0016021; GO:0017147; GO:0030154; GO:0030178; GO:0035414; GO:0035567; GO:0042813; GO:0043433; GO:0051898; GO:0060070; GO:0090090; GO:2000057 0 0 0 PF01392;PF01759; Q9Y2M2 CHOYP_POLD1.1.1 m.61170 sp SSUH2_HUMAN 34.672 274 169 3 10 281 88 353 4.56E-53 179 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 F1N6G5 CHOYP_LOC755521.12.28 m.39670 sp HACE1_BOVIN 37.952 166 102 1 1 166 86 250 4.57E-32 124 HACE1_BOVIN reviewed E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) HACE1 Bos taurus (Bovine) 909 "cell cycle [GO:0007049]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cell migration [GO:0030334]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000139; GO:0004842; GO:0005634; GO:0005737; GO:0005783; GO:0006351; GO:0006355; GO:0007030; GO:0007049; GO:0016567; GO:0016874; GO:0017137; GO:0030334; GO:0032580; GO:0042787; GO:0061025; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF00632; P10730 CHOYP_ISCW_ISCW002188.1.1 m.43928 sp ANPRC_BOVIN 30.323 155 98 4 20 166 48 200 4.57E-16 79 ANPRC_BOVIN reviewed Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) NPR3 ANPRC Bos taurus (Bovine) 537 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; cAMP-mediated signaling [GO:0019933]; osteoclast proliferation [GO:0002158]; positive regulation of urine volume [GO:0035810]; regulation of blood pressure [GO:0008217]; regulation of osteoblast proliferation [GO:0033688]; skeletal system development [GO:0001501] GO:0001501; GO:0002158; GO:0005622; GO:0005886; GO:0007193; GO:0008217; GO:0008528; GO:0016021; GO:0016941; GO:0019933; GO:0033688; GO:0035810 0 0 0 PF01094; P39858 CHOYP_BRAFLDRAFT_96436.1.1 m.36350 sp CAPI_STAAU 33.607 122 69 4 10 121 77 196 4.57E-07 52.4 CAPI_STAAU reviewed Protein CapI (EC 4.-.-.-) capI Staphylococcus aureus 334 capsule polysaccharide biosynthetic process [GO:0045227] GO:0016829; GO:0016857; GO:0045227; GO:0050662 PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis. 0 0 PF01370; P48148 CHOYP_RHO1.1.3 m.19520 sp RHO1_DROME 84.685 111 17 0 1 111 82 192 4.57E-66 200 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; Q01528 CHOYP_HAAF.3.13 m.8849 sp HAAF_LIMPO 48.193 83 41 1 1 81 90 172 4.57E-22 87.8 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q20363 CHOYP_ISCW_ISCW015266.1.1 m.57174 sp SIP1_CAEEL 36.25 80 49 2 75 153 49 127 4.57E-09 55.5 SIP1_CAEEL reviewed Stress-induced protein 1 sip-1 F43D9.4 Caenorhabditis elegans 159 determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; multicellular organismal protein metabolic process [GO:0044268]; response to heat [GO:0009408] GO:0005829; GO:0008340; GO:0009408; GO:0009792; GO:0044268; GO:0051082 0 0 0 PF00011; Q2KIR4 CHOYP_RPP25L.1.1 m.19940 sp RP25L_BOVIN 40.252 159 92 2 1 156 1 159 4.57E-37 128 RP25L_BOVIN reviewed Ribonuclease P protein subunit p25-like protein (RNase P protein subunit-like p25) (Rpp25-like protein) RPP25L Bos taurus (Bovine) 163 0 GO:0005634; GO:0044822 0 0 0 PF01918; Q2NL00 CHOYP_NEMVEDRAFT_V1G237669.1.1 m.7592 sp GSTT1_BOVIN 30.093 216 134 8 21 226 3 211 4.57E-20 89 GSTT1_BOVIN reviewed Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) GSTT1 Bos taurus (Bovine) 240 glutathione metabolic process [GO:0006749] GO:0004364; GO:0005737; GO:0006749 0 0 0 PF00043;PF02798; Q502M6 CHOYP_LOC755521.2.28 m.24805 sp ANR29_DANRE 37.788 217 134 1 1 217 49 264 4.57E-43 149 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q6PDZ2 CHOYP_NEMVEDRAFT_V1G241267.1.1 m.7467 sp TAF1C_MOUSE 21.77 418 297 12 163 559 206 614 4.57E-17 90.1 TAF1C_MOUSE reviewed TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 95 kDa) (TAFI95) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) Taf1c Mus musculus (Mouse) 836 chromatin silencing at rDNA [GO:0000183]; transcription from RNA polymerase I promoter [GO:0006360]; transcription initiation from RNA polymerase I promoter [GO:0006361] GO:0000120; GO:0000183; GO:0001164; GO:0005654; GO:0006360; GO:0006361; GO:0043231 0 0 0 0 Q7TMV1 CHOYP_LOC100368162.1.1 m.48831 sp RN139_MOUSE 37.936 659 358 10 8 644 23 652 4.57E-146 442 RN139_MOUSE reviewed E3 ubiquitin-protein ligase RNF139 (EC 6.3.2.-) (RING finger protein 139) (Translocation in renal carcinoma on chromosome 8 protein) Rnf139 Mus musculus (Mouse) 668 ERAD pathway [GO:0036503]; negative regulation of cell proliferation [GO:0008285]; negative regulation of translation [GO:0017148]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein processing [GO:0070613]; regulation of protein ubiquitination [GO:0031396] GO:0000209; GO:0002020; GO:0004842; GO:0005783; GO:0008270; GO:0008285; GO:0016021; GO:0016567; GO:0016874; GO:0017148; GO:0019787; GO:0031396; GO:0031648; GO:0036503; GO:0036513; GO:0042787; GO:0043161; GO:0060628; GO:0061630; GO:0070613; GO:2000060 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13705;PF13639; Q7XA86 CHOYP_LOC590681.1.2 m.17100 sp ZDH11_ARATH 33.465 254 139 7 46 280 63 305 4.57E-30 119 ZDH11_ARATH reviewed Protein S-acyltransferase 10 (EC 2.3.1.225) (Probable palmitoyltransferase At3g51390) (Zinc finger DHHC domain-containing protein At3g51390) PAT10 At3g51390 F26O13.30 Arabidopsis thaliana (Mouse-ear cress) 340 0 GO:0005774; GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q91YD4 CHOYP_TRPM5.1.2 m.59669 sp TRPM2_MOUSE 25.978 639 355 23 394 963 486 1075 4.57E-40 165 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q963B7 CHOYP_LOC752555.1.1 m.4462 sp RL9_SPOFR 63.636 132 48 0 12 143 1 132 4.57E-59 184 RL9_SPOFR reviewed 60S ribosomal protein L9 RpL9 Spodoptera frugiperda (Fall armyworm) 190 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00347; Q9BVK2 CHOYP_ALG8.2.2 m.29442 sp ALG8_HUMAN 59.545 220 81 2 8 225 17 230 4.57E-85 264 ALG8_HUMAN reviewed "Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG8 HUSSY-02 Homo sapiens (Human) 526 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487] GO:0000033; GO:0004583; GO:0005789; GO:0006487; GO:0006488; GO:0006490; GO:0016021; GO:0042281 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03155; Q9BZY9 CHOYP_LOC100374819.5.7 m.55770 sp TRI31_HUMAN 23.345 287 188 9 26 298 27 295 4.57E-07 55.1 TRI31_HUMAN reviewed E3 ubiquitin-protein ligase TRIM31 (EC 6.3.2.-) (Tripartite motif-containing protein 31) TRIM31 C6orf13 RNF Homo sapiens (Human) 425 innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; regulation of viral release from host cell [GO:1902186] GO:0005739; GO:0005829; GO:0008270; GO:0016567; GO:0016874; GO:0032897; GO:0045087; GO:0046597; GO:0051091; GO:0060333; GO:1902186 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643; Q9CXG3 CHOYP_NEMVEDRAFT_V1G96234.1.1 m.27743 sp PPIL4_MOUSE 62.745 408 141 2 1 397 1 408 4.57E-173 501 PPIL4_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) Ppil4 Mus musculus (Mouse) 492 protein folding [GO:0006457] GO:0000166; GO:0003755; GO:0005654; GO:0005737; GO:0006457; GO:0044822 0 0 0 PF00160;PF00076; Q9P215 CHOYP_LOC100371173.1.1 m.51378 sp POGK_HUMAN 27.083 144 93 3 16 159 394 525 4.57E-09 58.9 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9PV90 CHOYP_RLA0.1.7 m.4366 sp RLA0_DANRE 57.692 130 53 1 3 130 190 319 4.57E-35 125 RLA0_DANRE reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) rplp0 arp Danio rerio (Zebrafish) (Brachydanio rerio) 319 chordate embryonic development [GO:0043009]; cytoplasmic translation [GO:0002181]; ribosome biogenesis [GO:0042254] GO:0002181; GO:0003735; GO:0005634; GO:0022625; GO:0030687; GO:0042254; GO:0043009; GO:0070180 0 0 0 PF00466; Q9US12 CHOYP_LOC100199415.1.1 m.2675 sp YK66_SCHPO 38.614 101 57 2 47 143 234 333 4.57E-13 73.6 YK66_SCHPO reviewed Putative zinc metalloproteinase C607.06c (EC 3.4.24.-) SPAC607.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 612 0 GO:0005634; GO:0005829; GO:0008237; GO:0030246; GO:0032153; GO:0046872 0 0 0 PF12044; A1E295 CHOYP_CATB.1.2 m.5440 sp CATB_PIG 59.756 328 121 6 14 338 11 330 4.58E-141 405 CATB_PIG reviewed Cathepsin B (EC 3.4.22.1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB Sus scrofa (Pig) 335 cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of catalytic activity [GO:0050790]; viral entry into host cell [GO:0046718] GO:0004197; GO:0005615; GO:0005730; GO:0005739; GO:0005764; GO:0030574; GO:0030855; GO:0042470; GO:0043394; GO:0046697; GO:0046718; GO:0048471; GO:0050790; GO:0051603; GO:0070062; GO:0097067 0 0 0 PF00112;PF08127; A6NGW2 CHOYP_BRAFLDRAFT_124140.1.1 m.28392 sp STRCL_HUMAN 21.85 627 411 24 643 1247 1161 1730 4.58E-19 97.8 STRCL_HUMAN reviewed Putative stereocilin-like protein (Stereocilin pseudogene 1) STRCP1 STRCP Homo sapiens (Human) 1772 cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605] GO:0005576; GO:0007160; GO:0007605; GO:0009986; GO:0032426; GO:0060091 0 0 0 0 B3EWZ5 CHOYP_LOC580670.5.6 m.34028 sp MLRP1_ACRMI 24.209 1012 584 36 849 1777 704 1615 4.58E-55 218 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D8VNS7 CHOYP_BRAFLDRAFT_59661.1.6 m.19944 sp FCNV1_CERRY 49.007 151 67 4 3 152 128 269 4.58E-39 137 FCNV1_CERRY reviewed Ryncolin-1 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; O15990 CHOYP_KARG.5.11 m.15398 sp KARG_LIOJA 63.61 349 125 2 77 424 2 349 4.58E-159 455 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O57429 CHOYP_UBP8.1.1 m.63443 sp UBP2_CHICK 25.926 351 200 10 790 1099 18 349 4.58E-18 90.9 UBP2_CHICK reviewed Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Gallus gallus (Chicken) 357 protein deubiquitination [GO:0016579]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0016579; GO:0046872; GO:0048471; GO:0048511 0 0 0 PF00443; P19218 CHOYP_LOC100536772.1.2 m.42304 sp GP2_RAT 38.931 131 67 7 23 145 53 178 4.58E-15 81.3 GP2_RAT reviewed Pancreatic secretory granule membrane major glycoprotein GP2 (Glycoprotein 80) (gp80) (Pancreatic zymogen granule membrane protein GP-2) Gp2 Rattus norvegicus (Rat) 530 0 GO:0005576; GO:0005886; GO:0031225 0 0 0 PF00100; P22105 CHOYP_LOC100637925.3.4 m.48236 sp TENX_HUMAN 24.784 347 185 20 33 325 257 581 4.58E-06 53.5 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P43143 CHOYP_ACHA5.2.2 m.55057 sp ACHA6_RAT 23.651 482 304 14 4 426 10 486 4.58E-41 155 ACHA6_RAT reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) 493 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of dopamine secretion [GO:0033603]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0033603; GO:0035094; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; P86854 CHOYP_CLC10.1.5 m.2776 sp PLCL_MYTGA 25.984 127 90 2 19 141 30 156 4.58E-14 68.6 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q1EHB3 CHOYP_LOC409468.1.1 m.6340 sp ATS7_RAT 34.574 188 102 7 410 590 337 510 4.58E-14 79.7 ATS7_RAT reviewed A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS 7) (ADAM-TS7) (ADAMTS-7) (EC 3.4.24.-) (COMPase) Adamts7 Rattus norvegicus (Rat) 1595 cellular response to BMP stimulus [GO:0071773]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of chondrocyte differentiation [GO:0032331]; proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004222; GO:0005578; GO:0008270; GO:0009986; GO:0032331; GO:0051603; GO:0071347; GO:0071356; GO:0071773; GO:0098779 0 0 0 PF05986;PF01562;PF01421;PF00090; Q3SWX0 CHOYP_NIPA2.1.1 m.56770 sp NIPA2_BOVIN 59.683 315 126 1 64 377 9 323 4.58E-134 392 NIPA2_BOVIN reviewed Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog) NIPA2 Bos taurus (Bovine) 360 magnesium ion transport [GO:0015693] GO:0005769; GO:0005886; GO:0015095; GO:0015693; GO:0016021 0 0 0 PF05653; Q4A0Q1 CHOYP_LOC100877665.1.1 m.44938 sp BETA_STAS1 49.074 108 54 1 3 110 178 284 4.58E-25 101 BETA_STAS1 reviewed Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA SSP0196 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) 560 glycine betaine biosynthetic process from choline [GO:0019285] GO:0008802; GO:0008812; GO:0019285; GO:0050660 PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00750}. 0 0 PF05199;PF00732; Q5M8V0 CHOYP_BT3L4.1.1 m.2144 sp BT3L4_XENTR 78.205 156 32 2 19 172 1 156 4.58E-72 217 BT3L4_XENTR reviewed Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) btf3l4 TNeu120e23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 158 0 0 0 0 0 PF01849; Q5ZIL6 CHOYP_PHUM_PHUM060390.1.1 m.12994 sp TM41B_CHICK 65.323 124 43 0 1 124 144 267 4.58E-57 181 TM41B_CHICK reviewed Transmembrane protein 41B TMEM41B RCJMB04_25c20 Gallus gallus (Chicken) 269 nervous system development [GO:0007399] GO:0007399; GO:0016021 0 0 0 PF09335; Q6AXT0 CHOYP_RM37.1.1 m.14517 sp RM37_RAT 30.337 356 215 9 63 408 84 416 4.58E-41 154 RM37_RAT reviewed "39S ribosomal protein L37, mitochondrial (L37mt) (MRP-L37)" Mrpl37 Rattus norvegicus (Rat) 423 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005840; GO:0006412; GO:0044822 0 0 0 PF07147; Q8HXX6 CHOYP_LOC100346953.2.2 m.29860 sp SAP3_MACFA 31.469 143 96 2 57 198 47 188 4.58E-25 99.8 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q9DC11 CHOYP_PXDC2.2.3 m.21190 sp PXDC2_MOUSE 36.933 463 215 12 79 528 105 503 4.58E-74 247 PXDC2_MOUSE reviewed Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein) Plxdc2 Tem7r Mus musculus (Mouse) 530 0 GO:0005886; GO:0016021; GO:0070062 0 0 0 PF01437; Q9VXV9 CHOYP_LOC100377231.1.1 m.42429 sp WCSD_DROME 46.759 216 107 4 47 255 72 286 4.58E-54 181 WCSD_DROME reviewed WSCD family member CG9164 CG9164 Drosophila melanogaster (Fruit fly) 317 0 GO:0016021 0 0 0 0 A0JM12 CHOYP_LOC100707338.3.5 m.23770 sp MEG10_XENTR 46.667 90 41 5 13 101 574 657 4.59E-12 68.2 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A4IF63 CHOYP_BRAFLDRAFT_87294.5.6 m.64611 sp TRIM2_BOVIN 29.474 95 65 1 101 193 627 721 4.59E-06 50.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O08734 CHOYP_LOC588418.1.1 m.52575 sp BAK_MOUSE 38.743 191 104 4 12 202 4 181 4.59E-38 134 BAK_MOUSE reviewed Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) Bak1 Bak Mus musculus (Mouse) 209 activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; aging [GO:0007568]; apoptotic process [GO:0006915]; apoptotic process involved in patterning of blood vessels [GO:1902262]; apoptotic signaling pathway [GO:0097190]; B cell apoptotic process [GO:0001783]; B cell homeostasis [GO:0001782]; B cell negative selection [GO:0002352]; blood vessel remodeling [GO:0001974]; brain development [GO:0007420]; cell proliferation [GO:0008283]; cellular response to mechanical stimulus [GO:0071260]; cellular response to UV [GO:0034644]; cytolysis [GO:0019835]; endocrine pancreas development [GO:0031018]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; fibroblast apoptotic process [GO:0044346]; homeostasis of number of cells [GO:0048872]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; leukocyte homeostasis [GO:0001776]; limb morphogenesis [GO:0035108]; mitochondrial fusion [GO:0008053]; myeloid cell homeostasis [GO:0002262]; negative regulation of cell proliferation [GO:0008285]; negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471]; negative regulation of gene expression [GO:0010629]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; organ regeneration [GO:0031100]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of proteolysis [GO:0045862]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; post-embryonic camera-type eye morphogenesis [GO:0048597]; regulation of cell cycle [GO:0051726]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of protein heterodimerization activity [GO:0043497]; regulation of protein homodimerization activity [GO:0043496]; release of cytochrome c from mitochondria [GO:0001836]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to fungus [GO:0009620]; response to gamma radiation [GO:0010332]; response to hydrogen peroxide [GO:0042542]; response to mycotoxin [GO:0010046]; response to organic cyclic compound [GO:0014070]; response to UV-C [GO:0010225]; thymocyte apoptotic process [GO:0070242]; vagina development [GO:0060068] GO:0001776; GO:0001782; GO:0001783; GO:0001836; GO:0001974; GO:0002262; GO:0002352; GO:0005622; GO:0005739; GO:0005783; GO:0005829; GO:0006915; GO:0006919; GO:0007420; GO:0007568; GO:0008053; GO:0008283; GO:0008285; GO:0008630; GO:0008635; GO:0009620; GO:0010046; GO:0010225; GO:0010248; GO:0010332; GO:0010524; GO:0010629; GO:0014070; GO:0019835; GO:0031018; GO:0031100; GO:0031307; GO:0031966; GO:0032471; GO:0033137; GO:0034644; GO:0035108; GO:0042493; GO:0042542; GO:0042802; GO:0042803; GO:0043065; GO:0043496; GO:0043497; GO:0044325; GO:0044346; GO:0045471; GO:0045862; GO:0046872; GO:0046902; GO:0046930; GO:0046982; GO:0048597; GO:0048872; GO:0051726; GO:0051881; GO:0060068; GO:0070059; GO:0070242; GO:0071260; GO:0090200; GO:0097190; GO:0097192; GO:0097202; GO:1900103; GO:1902262 0 0 0 PF00452; O43614 CHOYP_LOC100374980.2.2 m.63006 sp OX2R_HUMAN 23.546 361 221 11 74 423 63 379 4.59E-10 64.7 OX2R_HUMAN reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Homo sapiens (Human) 444 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005886; GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P04323 CHOYP_contig_034701 m.39400 sp POL3_DROME 37.638 271 164 3 10 277 361 629 4.59E-55 198 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P16056 CHOYP_LOC589012.1.1 m.26892 sp MET_MOUSE 27.807 748 441 24 42 731 635 1341 4.59E-74 266 MET_MOUSE reviewed Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) Met Mus musculus (Mouse) 1379 activation of MAPK activity [GO:0000187]; adult behavior [GO:0030534]; brain development [GO:0007420]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; chemical synaptic transmission [GO:0007268]; endothelial cell morphogenesis [GO:0001886]; excitatory postsynaptic potential [GO:0060079]; glucose homeostasis [GO:0042593]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; liver development [GO:0001889]; modulation of synaptic transmission [GO:0050804]; muscle cell migration [GO:0014812]; muscle organ development [GO:0007517]; myoblast proliferation [GO:0051450]; myotube differentiation [GO:0014902]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-mediated programmed cell death [GO:1901299]; negative regulation of transforming growth factor beta production [GO:0071635]; placenta development [GO:0001890]; positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of glucose transport [GO:0010828]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777]; reactive oxygen species metabolic process [GO:0072593]; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [GO:0060665]; regulation of cellular response to oxidative stress [GO:1900407]; regulation of interleukin-6 production [GO:0032675]; semaphorin-plexin signaling pathway [GO:0071526]; skeletal muscle tissue development [GO:0007519] GO:0000187; GO:0001886; GO:0001889; GO:0001890; GO:0004672; GO:0005008; GO:0005524; GO:0007268; GO:0007420; GO:0007517; GO:0007519; GO:0009925; GO:0009986; GO:0010629; GO:0010828; GO:0014812; GO:0014902; GO:0016020; GO:0016021; GO:0019903; GO:0030534; GO:0032675; GO:0042593; GO:0045944; GO:0046777; GO:0048012; GO:0048754; GO:0050804; GO:0050918; GO:0051450; GO:0055013; GO:0060048; GO:0060079; GO:0060665; GO:0071526; GO:0071635; GO:0072593; GO:0098794; GO:1900407; GO:1900745; GO:1901299; GO:2001028 0 0 0 PF07714;PF01437;PF01403;PF01833; P21328 CHOYP_LOC100561123.12.28 m.12659 sp RTJK_DROME 27.007 274 156 12 1 260 590 833 4.59E-16 84.3 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P27169 CHOYP_ADA17.3.3 m.54971 sp PON1_HUMAN 36.164 365 216 6 1 361 4 355 4.59E-65 213 PON1_HUMAN reviewed Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) PON1 PON Homo sapiens (Human) 355 aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; cholesterol metabolic process [GO:0008203]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of binding [GO:0051099]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of transporter activity [GO:0032411]; response to external stimulus [GO:0009605]; response to fatty acid [GO:0070542]; response to fluoride [GO:1902617]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636] GO:0004063; GO:0004064; GO:0005509; GO:0005543; GO:0005576; GO:0005615; GO:0008203; GO:0009605; GO:0009636; GO:0010875; GO:0019439; GO:0031667; GO:0032411; GO:0034364; GO:0034366; GO:0042803; GO:0043231; GO:0046395; GO:0046434; GO:0046470; GO:0051099; GO:0070062; GO:0070542; GO:0072562; GO:0102007; GO:1902617 0 0 0 PF01731; P28827 CHOYP_PTPRM.3.15 m.34089 sp PTPRM_HUMAN 36.381 525 298 10 98 589 743 1264 4.59E-91 310 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P39872 CHOYP_KAT8.1.1 m.28311 sp RL3_BOVIN 80.159 252 50 0 10 261 1 252 4.59E-155 440 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; P50430 CHOYP_BRAFLDRAFT_246447.1.1 m.30255 sp ARSB_RAT 38.978 372 208 6 25 394 36 390 4.59E-83 271 ARSB_RAT reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb Rattus norvegicus (Rat) 528 autophagy [GO:0006914]; central nervous system development [GO:0007417]; colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005791; GO:0005794; GO:0006914; GO:0007417; GO:0007584; GO:0008152; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0043627; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; Q29485 CHOYP_PLMN.8.11 m.38839 sp PLMN_ERIEU 43.243 185 87 7 14 183 171 352 4.59E-35 137 PLMN_ERIEU reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Erinaceus europaeus (Western European hedgehog) 810 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; Q5F4A9 CHOYP_AR6P4.1.1 m.39936 sp AR6P4_CHICK 79.104 67 14 0 184 250 163 229 4.59E-33 123 AR6P4_CHICK reviewed ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL-6-interacting protein 4) (Aip-4) ARL6IP4 RCJMB04_1f2 Gallus gallus (Chicken) 231 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005634; GO:0005730; GO:0006397; GO:0008380; GO:0016607 0 0 0 PF10500; Q6NRV8 CHOYP_RNF165B.2.2 m.41450 sp R111B_XENLA 46.262 214 67 7 938 1127 763 952 4.59E-37 155 R111B_XENLA reviewed E3 ubiquitin-protein ligase arkadia-B (EC 6.3.2.-) (RING finger protein 111-B) rnf111-b Xenopus laevis (African clawed frog) 959 protein ubiquitination [GO:0016567] GO:0005634; GO:0005737; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15303;PF13639; Q6NUT3 CHOYP_LOC101158385.1.1 m.40208 sp MFS12_HUMAN 47.204 447 218 6 3 439 17 455 4.59E-136 404 MFS12_HUMAN reviewed Major facilitator superfamily domain-containing protein 12 MFSD12 C19orf28 Homo sapiens (Human) 480 transport [GO:0006810] GO:0005765; GO:0006810; GO:0016021 0 0 cd06174; 0 Q6R520 CHOYP_ACA1_091870.1.1 m.43726 sp CALM_OREMO 43.75 160 75 2 45 203 1 146 4.59E-41 139 CALM_OREMO reviewed Calmodulin (CaM) calm Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica) 149 0 GO:0005509 0 0 0 PF13499; Q6ZRF8 CHOYP_LOC100373906.1.2 m.21267 sp RN207_HUMAN 20.388 206 144 6 24 220 100 294 4.59E-09 62.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7TP17 CHOYP_LOC660381.1.1 m.6380 sp U2AF4_RAT 78.519 135 22 2 25 158 68 196 4.59E-72 220 U2AF4_RAT reviewed Splicing factor U2AF 26 kDa subunit (Liver regeneration-related protein LRRG157/LRRG158) (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) U2af1l4 Cb2-806 Cb2-807 Rattus norvegicus (Rat) 220 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005681; GO:0005737; GO:0016607; GO:0046872; GO:0089701 0 0 0 PF00076;PF00642; Q8C761 CHOYP_LOC100373809.2.2 m.46067 sp WDR60_MOUSE 32.663 1044 619 25 1 1022 1 982 4.59E-139 446 WDR60_MOUSE reviewed WD repeat-containing protein 60 Wdr60 Mus musculus (Mouse) 999 cell projection organization [GO:0030030] GO:0005615; GO:0005929; GO:0030030; GO:0070062 0 0 0 PF00400; Q8N5I4 CHOYP_DHRSX.2.2 m.56693 sp DHRSX_HUMAN 39.175 194 114 2 1 194 133 322 4.59E-34 127 DHRSX_HUMAN reviewed Dehydrogenase/reductase SDR family member on chromosome X (EC 1.1.-.-) (DHRSXY) (Short chain dehydrogenase/reductase family 46C member 1) (Short chain dehydrogenase/reductase family 7C member 6) DHRSX CXorf11 DHRS5X SDR46C1 SDR7C6 UNQ6508/PRO21433 Homo sapiens (Human) 330 0 GO:0016491 0 0 0 PF00106; Q91WV7 CHOYP_BRAFLDRAFT_265208.7.7 m.62510 sp SLC31_MOUSE 31.315 479 248 14 11 473 43 456 4.59E-63 220 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q91YK0 CHOYP_BRAFLDRAFT_67566.3.4 m.40582 sp LRC49_MOUSE 52.308 65 30 1 115 179 65 128 4.59E-16 78.2 LRC49_MOUSE reviewed Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79) Lrrc49 Mus musculus (Mouse) 686 0 GO:0005737; GO:0005874 0 0 0 0 Q92005 CHOYP_SRC.1.2 m.2511 sp EF1A_DANRE 91.765 85 6 1 1 85 1 84 4.59E-48 161 EF1A_DANRE reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Danio rerio (Zebrafish) (Brachydanio rerio) 462 0 GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737 0 0 0 PF03144;PF03143; Q96DM1 CHOYP_LOC100332396.1.1 m.6218 sp PGBD4_HUMAN 28.169 284 161 8 1 267 315 572 4.59E-24 104 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9NYZ2 CHOYP_SLC25A37.1.1 m.23410 sp MFRN1_HUMAN 59.672 305 116 4 5 303 34 337 4.59E-126 367 MFRN1_HUMAN reviewed Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37) SLC25A37 MFRN MSCP HT015 Homo sapiens (Human) 338 iron ion homeostasis [GO:0055072]; mitochondrial iron ion transport [GO:0048250]; translation [GO:0006412] GO:0003735; GO:0005381; GO:0005743; GO:0006412; GO:0016021; GO:0048250; GO:0055072 0 0 0 PF00153; Q9P2D7 CHOYP_LOC589850.1.1 m.63839 sp DYH1_HUMAN 72.05 161 45 0 1 161 1943 2103 4.59E-77 252 DYH1_HUMAN reviewed "Dynein heavy chain 1, axonemal (Axonemal beta dynein heavy chain 1) (Ciliary dynein heavy chain 1) (Heat shock regulated protein 1) (HSRF-1) (hDHC7)" DNAH1 DHC7 DNAHC1 KIAA1410 Homo sapiens (Human) 4330 cilium movement involved in cell motility [GO:0060294]; cilium or flagellum-dependent cell motility [GO:0001539]; epithelial cilium movement [GO:0003351]; inner dynein arm assembly [GO:0036159]; response to mechanical stimulus [GO:0009612]; sperm motility [GO:0030317] GO:0001539; GO:0003351; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0009612; GO:0016887; GO:0030286; GO:0030317; GO:0036126; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08393;PF03028;PF12777; Q9TU53 CHOYP_LOC100370254.1.1 m.54575 sp CUBN_CANLF 24.202 376 235 14 150 492 1070 1428 4.59E-14 79.7 CUBN_CANLF reviewed Cubilin CUBN Canis lupus familiaris (Dog) (Canis familiaris) 3620 cholesterol metabolic process [GO:0008203]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0005509; GO:0005765; GO:0006898; GO:0008203; GO:0010008; GO:0015031; GO:0016324; GO:0031419 0 0 0 PF00431;PF00008;PF12947;PF07645; Q9Y2I6 CHOYP_LOC583607.2.4 m.11567 sp NINL_HUMAN 36.893 103 58 2 40 135 156 258 4.59E-14 71.2 NINL_HUMAN reviewed Ninein-like protein NINL KIAA0980 NLP Homo sapiens (Human) 1382 G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226] GO:0000086; GO:0000226; GO:0005509; GO:0005815; GO:0005829; GO:0005856; GO:0005874 0 0 0 PF13499; E7FAM5 CHOYP_BRAFLDRAFT_88223.15.22 m.53347 sp LIN41_DANRE 30.345 145 96 1 20 159 537 681 4.60E-10 60.5 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; H2A0M7 CHOYP_PLSP.1.5 m.17001 sp PLSP_PINMG 41.121 214 110 6 8 210 128 336 4.60E-33 128 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O00339 CHOYP_MATN2.2.2 m.49583 sp MATN2_HUMAN 42.373 59 34 0 3 61 779 837 4.60E-07 55.8 MATN2_HUMAN reviewed Matrilin-2 MATN2 UNQ193/PRO219 Homo sapiens (Human) 956 axon guidance [GO:0007411]; dendrite regeneration [GO:0031104]; glial cell migration [GO:0008347]; neuron migration [GO:0001764]; response to axon injury [GO:0048678] GO:0001764; GO:0005509; GO:0005578; GO:0005604; GO:0007411; GO:0008347; GO:0031012; GO:0031104; GO:0048678 0 0 0 PF12662;PF07645;PF10393;PF00092; O34313 CHOYP_LOC591937.1.1 m.53812 sp NTPES_BACSU 27.835 485 283 16 5 436 668 1138 4.60E-41 163 NTPES_BACSU reviewed "Trifunctional nucleotide phosphoesterase protein YfkN [Includes: 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC 3.1.3.6) (EC 3.1.4.16); 5'-nucleotidase (EC 3.1.3.5)]" yfkN BSU07840 Bacillus subtilis (strain 168) 1462 nucleotide catabolic process [GO:0009166] GO:0000166; GO:0005576; GO:0005618; GO:0008253; GO:0008254; GO:0008663; GO:0009166; GO:0046872 0 0 0 PF02872;PF00149; P02362 CHOYP_RS7.3.9 m.17930 sp RS7_XENLA 83.505 194 30 2 14 205 1 194 4.60E-115 328 RS7_XENLA reviewed 40S ribosomal protein S7 (40S ribosomal protein S8) rps7 rps8 Xenopus laevis (African clawed frog) 194 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01251; Q0VDD8 CHOYP_LOC100370750.1.2 m.49378 sp DYH14_HUMAN 21.127 568 285 17 88 649 345 755 4.60E-15 83.6 DYH14_HUMAN reviewed "Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)" DNAH14 C1orf67 Homo sapiens (Human) 3507 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0007018; GO:0030286 0 0 0 PF12780;PF03028;PF12777; Q12955 CHOYP_LOC100369608.1.3 m.11971 sp ANK3_HUMAN 32.335 167 104 3 628 794 48 205 4.60E-17 90.5 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q15386 CHOYP_LOC100374388.2.2 m.2226 sp UBE3C_HUMAN 67.081 161 49 3 22 181 671 828 4.60E-64 217 UBE3C_HUMAN reviewed Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (HectH2) UBE3C KIAA0010 KIAA10 Homo sapiens (Human) 1083 protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0000502; GO:0004842; GO:0005622; GO:0005634; GO:0005737; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q3ZBG9 CHOYP_LOC755959.2.2 m.47101 sp PLS2_BOVIN 37.652 247 143 4 4 248 54 291 4.60E-59 192 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q5ZIE8 CHOYP_LOC100678585.1.1 m.18302 sp MCAF1_CHICK 47.857 140 56 4 131 259 947 1080 4.60E-29 119 MCAF1_CHICK reviewed Activating transcription factor 7-interacting protein 1 (MBD1-containing chromatin-associated factor 1) ATF7IP MCAF1 RCJMB04_27g4 Gallus gallus (Chicken) 1085 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF16788;PF16794; Q6AY08 CHOYP_LOC100368365.2.2 m.54052 sp AL2SB_RAT 24.34 341 227 9 159 487 76 397 4.60E-17 87 AL2SB_RAT reviewed Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog Als2cr12 Rattus norvegicus (Rat) 411 0 GO:0001520; GO:0005737; GO:0035686 0 0 0 0 Q80SY4 CHOYP_LOC100370069.2.14 m.25892 sp MIB1_MOUSE 42.254 71 38 2 232 302 13 80 4.60E-08 59.3 MIB1_MOUSE reviewed E3 ubiquitin-protein ligase MIB1 (EC 6.3.2.-) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) Mib1 Dip1 Kiaa1323 Mib Mus musculus (Mouse) 1006 blood vessel development [GO:0001568]; heart development [GO:0007507]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; negative regulation of neuron differentiation [GO:0045665]; neural tube formation [GO:0001841]; Notch signaling pathway [GO:0007219]; positive regulation of endocytosis [GO:0045807]; somitogenesis [GO:0001756] GO:0001568; GO:0001701; GO:0001756; GO:0001841; GO:0001947; GO:0004842; GO:0005813; GO:0005886; GO:0007219; GO:0007507; GO:0008270; GO:0014069; GO:0016874; GO:0031410; GO:0045665; GO:0045807 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q80V70 CHOYP_BRAFLDRAFT_224574.10.18 m.45524 sp MEGF6_MOUSE 37.821 156 79 5 1 145 1089 1237 4.60E-20 89 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8CHH5 CHOYP_DSPP.3.8 m.18043 sp GSC1L_MOUSE 34.074 135 88 1 1029 1163 685 818 4.60E-18 94.7 GSC1L_MOUSE reviewed GLTSCR1-like protein Gltscr1l Kiaa0240 Mus musculus (Mouse) 1074 0 0 0 0 0 PF15249; Q8ND56 CHOYP_LS14A.1.3 m.3365 sp LS14A_HUMAN 43.016 451 199 12 1 442 1 402 4.60E-79 258 LS14A_HUMAN reviewed Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) LSM14A C19orf13 FAM61A RAP55 RAP55A Homo sapiens (Human) 463 cytoplasmic mRNA processing body assembly [GO:0033962]; multicellular organism development [GO:0007275]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of translation [GO:0006417]; RIG-I signaling pathway [GO:0039529] GO:0000932; GO:0003690; GO:0003725; GO:0003727; GO:0005737; GO:0006417; GO:0007275; GO:0010494; GO:0033962; GO:0039529; GO:0043231; GO:0044822; GO:0060340 0 0 0 PF09532;PF12701; Q963B7 CHOYP_RL9.3.6 m.33414 sp RL9_SPOFR 65.556 90 31 0 11 100 1 90 4.60E-36 125 RL9_SPOFR reviewed 60S ribosomal protein L9 RpL9 Spodoptera frugiperda (Fall armyworm) 190 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00347; Q96MB7 CHOYP_LOC100716402.1.1 m.36364 sp HARB1_HUMAN 27.562 283 197 4 94 372 45 323 4.60E-26 110 HARB1_HUMAN reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) HARBI1 C11orf77 Homo sapiens (Human) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0005813; GO:0046872 0 0 0 PF13359; Q9D1J3 CHOYP_SARNP.1.1 m.46095 sp SARNP_MOUSE 36.929 241 113 9 1 234 1 209 4.60E-24 98.6 SARNP_MOUSE reviewed SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) Sarnp Hcc1 Mus musculus (Mouse) 210 "mRNA export from nucleus [GO:0006406]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000346; GO:0000978; GO:0001078; GO:0005634; GO:0005654; GO:0006351; GO:0006406; GO:0006417; GO:0008022; GO:0016607; GO:0043231; GO:0044822; GO:0050733 0 0 0 PF02037; Q9I931 CHOYP_LOC100373240.1.1 m.28382 sp FUCL1_ANGJA 38.525 122 66 5 81 199 56 171 4.60E-14 70.5 FUCL1_ANGJA reviewed Fucolectin-1 0 Anguilla japonica (Japanese eel) 178 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9QZS6 CHOYP_HS3SB.1.2 m.27480 sp HS3SB_MOUSE 55.932 295 128 1 97 389 95 389 4.60E-114 341 HS3SB_MOUSE reviewed Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (m3-OST-3B) Hs3st3b1 3ost3b1 Hs3st3b Mus musculus (Mouse) 390 protein sulfation [GO:0006477] GO:0000139; GO:0005887; GO:0006477; GO:0008467; GO:0033872 0 0 0 PF00685; Q9UHY8 CHOYP_LOC664535.1.1 m.40357 sp FEZ2_HUMAN 40 355 197 6 33 378 6 353 4.60E-53 182 FEZ2_HUMAN reviewed Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2) FEZ2 Homo sapiens (Human) 353 axon guidance [GO:0007411]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; signal transduction [GO:0007165] GO:0007165; GO:0007399; GO:0007411; GO:1902902 0 0 0 PF07763; B3EWZ5 CHOYP_LOC752805.1.3 m.18031 sp MLRP1_ACRMI 38.323 167 85 6 71 220 926 1091 4.61E-26 110 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E7F6F9 CHOYP_NS1BP.2.2 m.8103 sp KLHL3_DANRE 36.364 66 41 1 1 65 214 279 4.61E-06 47 KLHL3_DANRE reviewed Kelch-like protein 3 klhl3 Danio rerio (Zebrafish) (Brachydanio rerio) 601 distal tubule morphogenesis [GO:0072156]; ion homeostasis [GO:0050801]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; renal sodium ion absorption [GO:0070294] GO:0005829; GO:0005856; GO:0016567; GO:0031463; GO:0042787; GO:0050801; GO:0070294; GO:0070936; GO:0072156 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; F6ZQ54 CHOYP_BRAFLDRAFT_249727.1.1 m.57295 sp TRI13_XENTR 27.027 296 176 12 5 271 3 287 4.61E-20 96.3 TRI13_XENTR reviewed Tripartite motif containing 13 trim13 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 408 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; O15990 CHOYP_KARG.3.11 m.2494 sp KARG_LIOJA 64.486 214 75 1 26 238 1 214 4.61E-95 286 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O43301 CHOYP_BRAFLDRAFT_208293.4.20 m.33864 sp HS12A_HUMAN 31.513 641 360 16 1 584 56 674 4.61E-95 308 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P0DJG4 CHOYP_LOC100185861.1.1 m.12385 sp THEGL_HUMAN 29.016 193 99 6 64 245 244 409 4.61E-10 62.4 THEGL_HUMAN reviewed Testicular haploid expressed gene protein-like (Theg spermatid-like protein) THEGL Homo sapiens (Human) 465 0 0 0 0 0 PF14912; P20478 CHOYP_GLNA.2.5 m.1721 sp GLNA2_DROME 76.033 121 29 0 1 121 249 369 4.61E-61 194 GLNA2_DROME reviewed Glutamine synthetase 2 cytoplasmic (EC 6.3.1.2) (Glutamate--ammonia ligase 2) Gs2 CG1743 Drosophila melanogaster (Fruit fly) 369 glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; neurotransmitter receptor metabolic process [GO:0045213]; synapse assembly [GO:0007416] GO:0004356; GO:0005524; GO:0005737; GO:0006538; GO:0006542; GO:0007416; GO:0045213 0 0 0 PF00120;PF03951; P27473 CHOYP_IFI44.1.1 m.62857 sp IFI44_PANTR 32.685 257 171 2 107 362 168 423 4.61E-43 158 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; P47911 CHOYP_LOC100186361.1.3 m.17829 sp RL6_MOUSE 70.37 81 23 1 73 152 100 180 4.61E-30 113 RL6_MOUSE reviewed 60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) Rpl6 Mus musculus (Mouse) 296 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; Q0P5B3 CHOYP_AGAP_AGAP010391.1.2 m.10423 sp RBTN1_BOVIN 79.032 124 26 0 107 230 21 144 4.61E-71 218 RBTN1_BOVIN reviewed Rhombotin-1 (LIM domain only protein 1) (LMO-1) LMO1 RBTN1 Bos taurus (Bovine) 156 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of T cell homeostatic proliferation [GO:0046013] GO:0000122; GO:0005634; GO:0008270; GO:0045944; GO:0046013 0 0 0 PF00412; Q4QQV8 CHOYP_CHMP5.1.1 m.66827 sp CHMP5_RAT 71.364 220 61 2 1 219 1 219 4.61E-110 318 CHMP5_RAT reviewed Charged multivesicular body protein 5 (Chromatin-modifying protein 5) Chmp5 Rattus norvegicus (Rat) 219 cell separation after cytokinesis [GO:0000920]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; mitotic metaphase plate congression [GO:0007080]; multivesicular body sorting pathway [GO:0071985]; nucleus organization [GO:0006997]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of receptor recycling [GO:0001919]; viral budding [GO:0046755] GO:0000920; GO:0001919; GO:0005634; GO:0005829; GO:0006997; GO:0007040; GO:0007080; GO:0008333; GO:0010008; GO:0010824; GO:0015031; GO:0046755; GO:0070062; GO:0071985; GO:1901673 0 0 0 PF03357; Q70LM4 CHOYP_BRAFLDRAFT_128033.2.2 m.54293 sp LGRD_BREPA 31.538 1040 632 21 6 1026 4087 5065 4.61E-140 477 LGRD_BREPA reviewed Linear gramicidin synthase subunit D [Includes: ATP-dependent D-leucine adenylase (D-LeuA) (D-leucine activase); Leucine racemase [ATP-hydrolyzing] (EC 5.1.1.-); ATP-dependent tryptophan adenylase (TrpA) (Tryptophan activase); ATP-dependent glycine adenylase (GlyA) (Glycine activase); Linear gramicidin--PCP reductase (EC 1.-.-.-)] lgrD Brevibacillus parabrevis 5085 antibiotic biosynthetic process [GO:0017000] GO:0016491; GO:0016853; GO:0016874; GO:0017000; GO:0031177 0 0 cd05235; PF00501;PF13193;PF00668;PF07993;PF00550; Q8IZR5 CHOYP_LOC100368692.1.2 m.22849 sp CKLF4_HUMAN 31.933 119 74 3 45 160 88 202 4.61E-07 51.2 CKLF4_HUMAN reviewed CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine-like factor superfamily member 4) CMTM4 CKLFSF4 Homo sapiens (Human) 234 chemotaxis [GO:0006935] GO:0005615; GO:0006935; GO:0016021 0 0 0 PF01284; Q8NBJ4 CHOYP_BRAFLDRAFT_88543.2.2 m.58309 sp GOLM1_HUMAN 26.619 139 95 2 52 186 3 138 4.61E-07 54.3 GOLM1_HUMAN reviewed Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326 Homo sapiens (Human) 401 nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216] GO:0005615; GO:0005794; GO:0005887; GO:0006997; GO:0019216; GO:0070062 0 0 0 0 Q8NBN7 CHOYP_RDH13.1.3 m.10433 sp RDH13_HUMAN 36.392 316 195 2 54 363 11 326 4.61E-58 194 RDH13_HUMAN reviewed Retinol dehydrogenase 13 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 7C member 3) RDH13 SDR7C3 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) 331 eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842] GO:0005743; GO:0009644; GO:0010842; GO:0016491; GO:0042462; GO:0052650 0 0 0 PF00106; Q8TC07 CHOYP_LOC100374734.1.1 m.18442 sp TBC15_HUMAN 34.722 216 130 3 309 513 386 601 4.61E-32 135 TBC15_HUMAN reviewed TBC1 domain family member 15 (GTPase-activating protein RAB7) (GAP for RAB7) (Rab7-GAP) TBC1D15 Homo sapiens (Human) 691 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of GTPase activity [GO:0043087]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0005737; GO:0005739; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0043087; GO:0070062; GO:0090630 0 0 0 PF12068;PF00566; Q9C040 CHOYP_TRIM2.41.59 m.43626 sp TRIM2_HUMAN 19.509 692 451 23 69 718 117 744 4.61E-12 73.2 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9D2Z4 CHOYP_BRAFLDRAFT_221105.1.2 m.172 sp SENP8_MOUSE 43.062 209 117 2 30 237 4 211 4.61E-56 181 SENP8_MOUSE reviewed Sentrin-specific protease 8 (EC 3.4.22.68) (Deneddylase-1) (NEDD8-specific protease 1) (Sentrin/SUMO-specific protease SENP8) Senp8 Den1 Nedp1 Mus musculus (Mouse) 221 0 GO:0008234; GO:0019784 0 0 0 PF02902; Q9DD78 CHOYP_LOC100370996.1.1 m.48847 sp TLR21_CHICK 29.907 321 205 8 209 521 484 792 4.61E-41 161 TLR21_CHICK reviewed Toll-like receptor 2 type-1 TLR2-1 Gallus gallus (Chicken) 793 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0004872; GO:0004888; GO:0005886; GO:0006954; GO:0016021; GO:0031226; GO:0034134; GO:0045087 0 0 0 PF13855;PF01582; Q9H0J4 CHOYP_contig_018153 m.21280 sp QRIC2_HUMAN 28.866 97 69 0 36 132 608 704 4.61E-08 53.5 QRIC2_HUMAN reviewed Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 0 0 0 0 0 PF16043; Q9V3R8 CHOYP_UBIA1.1.1 m.15000 sp UBIA1_DROME 55.224 268 117 2 40 305 59 325 4.61E-108 321 UBIA1_DROME reviewed UbiA prenyltransferase domain-containing protein 1 homolog (EC 2.5.1.-) (Protein heixuedian) heix CG5876 Drosophila melanogaster (Fruit fly) 359 larval lymph gland hemopoiesis [GO:0035167]; menaquinone biosynthetic process [GO:0009234]; mitochondrion morphogenesis [GO:0070584]; negative regulation of hemocyte proliferation [GO:0035207]; negative regulation of lamellocyte differentiation [GO:0035204]; regulation of hemocyte differentiation [GO:0045610]; regulation of JAK-STAT cascade [GO:0046425]; regulation of MAPK cascade [GO:0043408]; regulation of Ras protein signal transduction [GO:0046578]; regulation of Toll signaling pathway [GO:0008592] GO:0004659; GO:0005739; GO:0005783; GO:0008592; GO:0009234; GO:0012505; GO:0016020; GO:0016021; GO:0031966; GO:0035167; GO:0035204; GO:0035207; GO:0043408; GO:0045610; GO:0046425; GO:0046578; GO:0070584 PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis. 0 0 PF01040; A4IF63 CHOYP_BRAFLDRAFT_205965.2.43 m.3258 sp TRIM2_BOVIN 23.776 143 104 3 122 260 602 743 4.62E-08 57.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5IJJ8 CHOYP_LOC100697793.4.6 m.55316 sp DPO3_THEP1 27.941 204 116 9 72 269 355 533 4.62E-07 54.3 DPO3_THEP1 reviewed DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC Tpet_0342 Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995) 1367 DNA-dependent DNA replication [GO:0006261] GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 0 0 0 PF07733;PF14579;PF02811;PF00929; O73630 CHOYP_Y220.1.6 m.10229 sp NFKB2_XENLA 31.902 163 103 4 20 176 553 713 4.62E-14 73.9 NFKB2_XENLA reviewed Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] nfkb2 Xenopus laevis (African clawed frog) 958 "NIK/NF-kappaB signaling [GO:0038061]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0006357; GO:0038061; GO:0048511 0 0 0 PF12796;PF00531;PF16179;PF00554; O94759 CHOYP_TRPM4C.3.3 m.62519 sp TRPM2_HUMAN 27 500 298 15 462 922 622 1093 4.62E-38 158 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; P39872 CHOYP_LOC100120962.1.1 m.42488 sp RL3_BOVIN 81.325 166 31 0 17 182 1 166 4.62E-100 298 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; Q13201 CHOYP_LOC100696977.1.2 m.2928 sp MMRN1_HUMAN 33.088 136 74 5 129 258 1101 1225 4.62E-08 57 MMRN1_HUMAN reviewed Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] MMRN1 ECM EMILIN4 GPIA* MMRN Homo sapiens (Human) 1228 blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; platelet degranulation [GO:0002576] GO:0002576; GO:0005509; GO:0005576; GO:0007155; GO:0007596; GO:0031012; GO:0031093 0 0 0 PF00386;PF00008;PF07546; Q2EMV9 CHOYP_LOC100928016.6.6 m.56550 sp PAR14_MOUSE 29.368 269 157 5 592 843 1041 1293 4.62E-21 105 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5XI81 CHOYP_FMRP.1.2 m.37742 sp FXR1_RAT 55.224 402 165 6 1 401 1 388 4.62E-151 454 FXR1_RAT reviewed Fragile X mental retardation syndrome-related protein 1 Fxr1 Fxr1h Rattus norvegicus (Rat) 568 cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of translation [GO:0017148]; positive regulation of gene silencing by miRNA [GO:2000637] GO:0003729; GO:0005634; GO:0005737; GO:0005844; GO:0007517; GO:0017148; GO:0030154; GO:0033592; GO:0042803; GO:0046982; GO:2000637 0 0 0 PF05641;PF12235;PF16096;PF00013; Q8K0U4 CHOYP_HS12B.7.14 m.40600 sp HS12A_MOUSE 34.921 630 348 15 5 580 52 673 4.62E-119 370 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q90871 CHOYP_IRF5.1.1 m.58123 sp IRF8_CHICK 29.828 466 245 15 22 469 8 409 4.62E-52 184 IRF8_CHICK reviewed Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP) IRF8 ICSBP ICSBP1 Gallus gallus (Chicken) 425 "cellular response to lipopolysaccharide [GO:0071222]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; immune response [GO:0006955]; myeloid cell differentiation [GO:0030099]; negative regulation of growth of symbiont in host [GO:0044130]; phagocytosis [GO:0006909]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; transcription, DNA-templated [GO:0006351]" GO:0000975; GO:0003700; GO:0005654; GO:0006351; GO:0006909; GO:0006955; GO:0030099; GO:0032729; GO:0032735; GO:0042742; GO:0042832; GO:0044130; GO:0060261; GO:0071222 0 0 0 PF00605;PF10401; Q923G2 CHOYP_RPAB3.1.4 m.10473 sp RPAB3_MOUSE 82.456 114 19 1 1 113 37 150 4.62E-62 189 RPAB3_MOUSE reviewed "DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (RPB17) (RPB8 homolog)" Polr2h Mus musculus (Mouse) 150 piRNA metabolic process [GO:0034587]; transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase II promoter [GO:0006366]; transcription from RNA polymerase I promoter [GO:0006360] GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0005666; GO:0005736; GO:0006360; GO:0006366; GO:0006383; GO:0034587 0 0 0 PF03870; Q96MM6 CHOYP_BRAFLDRAFT_102685.1.1 m.48317 sp HS12B_HUMAN 28.814 236 152 5 4 226 454 686 4.62E-30 120 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9DA42 CHOYP_LOC100705082.1.1 m.45788 sp CT085_MOUSE 30.769 143 70 8 5 133 7 134 4.62E-06 46.2 CT085_MOUSE reviewed Uncharacterized protein C20orf85 homolog 0 Mus musculus (Mouse) 136 0 0 0 0 0 PF14945; Q9HCF6 CHOYP_SMP_173720.1.3 m.6590 sp TRPM3_HUMAN 28.132 1269 692 38 50 1171 64 1259 4.62E-141 476 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9UGM3 CHOYP_DMBT1.7.34 m.6011 sp DMBT1_HUMAN 40.336 357 162 5 4 311 1432 1786 4.62E-68 233 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; P04323 CHOYP_LOC754701.5.7 m.31503 sp POL3_DROME 40.16 376 209 8 1 367 235 603 4.63E-88 289 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P06172 CHOYP_RET4.1.1 m.5154 sp RET4_XENLA 29.348 184 109 7 8 179 9 183 4.63E-17 78.6 RET4_XENLA reviewed Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) rbp4 Xenopus laevis (African clawed frog) 197 0 GO:0005215; GO:0005576; GO:0016918; GO:0019841 0 0 0 PF00061; P13086 CHOYP_BRAFLDRAFT_124275.1.1 m.8900 sp SUCA_RAT 77.143 315 71 1 52 365 26 340 4.63E-163 463 SUCA_RAT reviewed "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)" Suclg1 Rattus norvegicus (Rat) 346 nucleoside triphosphate biosynthetic process [GO:0009142]; succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] GO:0004775; GO:0004776; GO:0005525; GO:0005739; GO:0006099; GO:0006104; GO:0006105; GO:0009142; GO:0019003; GO:0043234; GO:0045244; GO:0046982; GO:0048037 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle. 0 0 PF02629;PF00549; P78316 CHOYP_LOC100368659.2.2 m.20762 sp NOP14_HUMAN 44.268 314 166 5 312 619 341 651 4.63E-70 246 NOP14_HUMAN reviewed Nucleolar protein 14 (Nucleolar complex protein 14) NOP14 C4orf9 NOL14 RES4-25 Homo sapiens (Human) 857 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005634; GO:0005654; GO:0005730; GO:0005739; GO:0006364; GO:0016020; GO:0019899; GO:0030490; GO:0030515; GO:0030686; GO:0030692; GO:0032040; GO:0042274; GO:0044822 0 0 0 PF04147; P78559 CHOYP_NEMVEDRAFT_V1G196687.1.1 m.20786 sp MAP1A_HUMAN 36.792 106 57 3 328 423 1402 1507 4.63E-11 69.3 MAP1A_HUMAN reviewed Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] MAP1A MAP1L Homo sapiens (Human) 2803 microtubule cytoskeleton organization [GO:0000226]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0000226; GO:0002230; GO:0005198; GO:0005737; GO:0005874; GO:0005875; GO:0007026; GO:0098779; GO:0098792 0 0 0 0 P78559 CHOYP_contig_030316 m.34502 sp MAP1A_HUMAN 23.841 151 110 2 296 441 1386 1536 4.63E-10 66.2 MAP1A_HUMAN reviewed Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] MAP1A MAP1L Homo sapiens (Human) 2803 microtubule cytoskeleton organization [GO:0000226]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0000226; GO:0002230; GO:0005198; GO:0005737; GO:0005874; GO:0005875; GO:0007026; GO:0098779; GO:0098792 0 0 0 0 P82596 CHOYP_AJL2.1.1 m.26431 sp PLC_HALLA 35.878 131 81 3 31 160 2 130 4.63E-22 89.7 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q2KNA0 CHOYP_CYTSA.1.1 m.15874 sp CYTSA_CANLF 33.754 1031 510 26 182 1095 142 1116 4.63E-138 448 CYTSA_CANLF reviewed Cytospin-A (SPECC1-like protein) (Sperm antigen with calponin homology and coiled-coil domains 1-like) SPECC1L CYTSA Canis lupus familiaris (Dog) (Canis familiaris) 1117 cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005737; GO:0005819; GO:0005921; GO:0007049; GO:0007155; GO:0051301 0 0 0 PF00307; Q3T100 CHOYP_NEMVEDRAFT_V1G240887.1.2 m.18082 sp MGST3_BOVIN 50.746 134 63 1 11 141 4 137 4.63E-41 137 MGST3_BOVIN reviewed Microsomal glutathione S-transferase 3 (Microsomal GST-3) (EC 2.5.1.18) MGST3 Bos taurus (Bovine) 152 0 GO:0004364; GO:0004602; GO:0005635; GO:0005783; GO:0005789; GO:0016021; GO:0031090; GO:0070062 0 0 0 PF01124; Q5ND28 CHOYP_CED1.12.29 m.33479 sp SREC_MOUSE 30.677 251 130 11 185 418 168 391 4.63E-17 88.2 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5ZL74 CHOYP_LOC100378492.1.1 m.36586 sp VAMP7_CHICK 68.372 215 68 0 1 215 1 215 4.63E-101 295 VAMP7_CHICK reviewed Vesicle-associated membrane protein 7 (Synaptobrevin-like protein 1) VAMP7 SYBL1 RCJMB04_7f19 Gallus gallus (Chicken) 220 "calcium ion regulated exocytosis [GO:0017156]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of histamine secretion by mast cell [GO:1903595]; regulation of protein targeting to vacuolar membrane [GO:1900483]; SNARE complex assembly [GO:0035493]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" GO:0000149; GO:0005484; GO:0005765; GO:0005789; GO:0005802; GO:0005886; GO:0006887; GO:0006888; GO:0006897; GO:0006906; GO:0006911; GO:0008333; GO:0009986; GO:0016021; GO:0016192; GO:0017156; GO:0030027; GO:0030054; GO:0030658; GO:0030670; GO:0031091; GO:0031143; GO:0031201; GO:0031902; GO:0035493; GO:0035577; GO:0043001; GO:0043005; GO:0043308; GO:0043312; GO:0043320; GO:0045177; GO:0045202; GO:0045335; GO:0048471; GO:0050775; GO:0070062; GO:1900483; GO:1903595 0 0 0 PF13774;PF00957; Q6QRN8 CHOYP_PHUM_PHUM012540.3.4 m.25907 sp LAP4A_BOVIN 31.982 222 132 4 68 289 18 220 4.63E-28 111 LAP4A_BOVIN reviewed Lysosomal-associated transmembrane protein 4A LAPTM4A Bos taurus (Bovine) 233 transport [GO:0006810] GO:0005794; GO:0006810; GO:0016020; GO:0016021 0 0 0 PF03821; Q717R8 CHOYP_EF1B.4.7 m.41495 sp EF1D_SHEEP 34.247 146 76 4 17 157 6 136 4.63E-17 79 EF1D_SHEEP reviewed Elongation factor 1-delta (EF-1-delta) EEF1D Ovis aries (Sheep) 277 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; Q7Z7G8 CHOYP_VP13B.1.2 m.3294 sp VP13B_HUMAN 26.667 1170 730 32 2 1068 1392 2536 4.63E-118 406 VP13B_HUMAN reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) 4022 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q7Z7G8 CHOYP_VP13B.2.2 m.32332 sp VP13B_HUMAN 27.562 1259 780 30 1 1166 1701 2920 4.63E-144 486 VP13B_HUMAN reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) 4022 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q8CFR0 CHOYP_C1QL2.7.32 m.4542 sp C1QL2_MOUSE 33.577 137 80 6 159 291 157 286 4.63E-09 60.8 C1QL2_MOUSE reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10) C1ql2 C1qtnf10 Ctrp10 Mus musculus (Mouse) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0042802; GO:0051259 0 0 0 PF00386; Q8Q0U0 CHOYP_TVAG_485460.1.1 m.23564 sp Y045_METMA 39.153 189 106 7 2 185 142 326 4.63E-25 102 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q92851 CHOYP_LOC101240339.1.1 m.64430 sp CASPA_HUMAN 35.766 137 72 4 14 148 280 402 4.63E-17 87.4 CASPA_HUMAN reviewed Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005829; GO:0006915; GO:0007166; GO:0008625; GO:0030225; GO:0031265; GO:0031625; GO:0035877; GO:0042981; GO:0043123; GO:0097190; GO:0097199; GO:0097342 0 0 0 PF01335; B3EWZ5 CHOYP_NEMVEDRAFT_V1G198667.10.15 m.26218 sp MLRP1_ACRMI 30.776 1134 620 46 237 1281 1450 2507 4.64E-109 384 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; E7FAM5 CHOYP_LOC100378676.7.8 m.63402 sp LIN41_DANRE 20.351 570 340 16 30 488 164 730 4.64E-07 56.2 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O08593 CHOYP_PDE7A.1.1 m.43602 sp PDE7A_RAT 48.289 263 128 5 1 256 9 270 4.64E-76 239 PDE7A_RAT reviewed "High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (Rolipram-insensitive phosphodiesterase type 7) (Fragment)" Pde7a Rattus norvegicus (Rat) 426 cAMP catabolic process [GO:0006198]; cAMP-mediated signaling [GO:0019933] GO:0004112; GO:0004115; GO:0006198; GO:0019933; GO:0046872 "PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1." 0 0 PF00233; O15182 CHOYP_LOC100313573.1.1 m.62977 sp CETN3_HUMAN 84.94 166 25 0 1 166 1 166 4.64E-99 285 CETN3_HUMAN reviewed Centrin-3 CETN3 CEN3 Homo sapiens (Human) 167 cell division [GO:0051301]; centrosome cycle [GO:0007098]; mitotic nuclear division [GO:0007067] GO:0005509; GO:0005730; GO:0005813; GO:0005814; GO:0007067; GO:0007098; GO:0051301 0 0 0 PF13499; P22031 CHOYP_BRAFLDRAFT_95854.4.6 m.48566 sp LEG_HELCR 44.444 90 48 1 318 405 13 102 4.64E-19 85.5 LEG_HELCR reviewed D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 105 0 GO:0005737; GO:0030246 0 0 0 PF02140; P54353 CHOYP_ND5.1.6 m.492 sp DOD_DROME 63.226 155 46 1 90 233 12 166 4.64E-61 192 DOD_DROME reviewed Putative peptidyl-prolyl cis-trans isomerase dodo (PPIase dodo) (EC 5.2.1.8) (Rotamase dodo) dod CG17051 Drosophila melanogaster (Fruit fly) 166 epidermal growth factor receptor signaling pathway [GO:0007173] GO:0003755; GO:0005634; GO:0007173 0 0 0 PF00639;PF00397; Q01484 CHOYP_TVAG_168010.13.45 m.34612 sp ANK2_HUMAN 37.6 125 78 0 9 133 235 359 4.64E-23 97.1 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q03601 CHOYP_NHL1.6.6 m.64624 sp NHL1_CAEEL 30.702 114 74 3 106 217 730 840 4.64E-07 53.5 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q20930 CHOYP_CRE-MIG-17.1.1 m.62167 sp MIG17_CAEEL 32.584 267 155 13 267 513 198 459 4.64E-27 119 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q3B7D5 CHOYP_LOC100692244.1.1 m.1647 sp RASF2_RAT 32.177 317 150 10 38 331 48 322 4.64E-31 122 RASF2_RAT reviewed Ras association domain-containing protein 2 Rassf2 Rattus norvegicus (Rat) 326 cell cycle [GO:0007049]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] GO:0000776; GO:0000777; GO:0005634; GO:0005737; GO:0007049; GO:0007165; GO:0042981 0 0 0 PF16517;PF00788; Q4KLI9 CHOYP_LOC100142053.2.2 m.50005 sp FBXW5_RAT 49.035 259 127 3 6 263 3 257 4.64E-76 258 FBXW5_RAT reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) 569 centrosome duplication [GO:0051298]; mitotic nuclear division [GO:0007067]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000151; GO:0005737; GO:0007067; GO:0010824; GO:0016567; GO:0019005; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q5RD73 CHOYP_ISCW_ISCW009547.1.1 m.58366 sp DUS3_PONAB 45.109 184 99 2 189 371 2 184 4.64E-49 166 DUS3_PONAB reviewed Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Vaccinia H1-related phosphatase) (VHR) DUSP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 185 dephosphorylation [GO:0016311]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of mitotic cell cycle [GO:0045931] GO:0001772; GO:0004725; GO:0005654; GO:0005829; GO:0008138; GO:0016311; GO:0016791; GO:0033549; GO:0045931; GO:0046329; GO:0050860; GO:0050868; GO:0070062; GO:0070373 0 0 0 PF00782; Q5SSI6 CHOYP_LOC100378445.1.1 m.7111 sp UTP18_MOUSE 44.842 475 246 7 37 495 78 552 4.64E-132 396 UTP18_MOUSE reviewed U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50) Utp18 Wdr50 Mus musculus (Mouse) 552 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" GO:0000462; GO:0005634; GO:0005730; GO:0032040; GO:0034388; GO:0044822 0 0 0 0 Q6DFV8 CHOYP_NEMVEDRAFT_V1G214844.29.34 m.57719 sp VWDE_MOUSE 23.761 585 366 27 40 582 60 606 4.64E-15 84 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q8IUM7 CHOYP_BRAFLDRAFT_121518.1.1 m.3040 sp NPAS4_HUMAN 37.725 334 189 7 16 341 3 325 4.64E-58 216 NPAS4_HUMAN reviewed Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10) NPAS4 BHLHE79 NXF PASD10 Homo sapiens (Human) 802 cellular response to corticosterone stimulus [GO:0071386]; inhibitory postsynaptic potential [GO:0060080]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0005634; GO:0005667; GO:0045944; GO:0060080; GO:0071386; GO:0098794 0 0 0 PF08447; Q8MJC3 CHOYP_LOC100672256.1.1 m.47170 sp CASP3_RABIT 49.402 251 116 2 38 287 35 275 4.64E-80 246 CASP3_RABIT reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q8R3S2 CHOYP_TSN33.3.3 m.58845 sp TSN33_MOUSE 41.026 234 125 5 5 236 12 234 4.64E-53 176 TSN33_MOUSE reviewed Tetraspanin-33 (Tspan-33) (Penumbra) (mPen) (Proerythroblast new membrane) Tspan33 Pen Mus musculus (Mouse) 283 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005886; GO:0005887; GO:0007166; GO:0009986; GO:0019899; GO:0045747; GO:0051604; GO:0090002; GO:0097197 0 0 0 PF00335; Q96JP0 CHOYP_LOC755521.16.28 m.46387 sp FEM1C_HUMAN 38.679 106 60 3 117 220 76 178 4.64E-13 71.2 FEM1C_HUMAN reviewed Protein fem-1 homolog C (FEM1c) (FEM1-gamma) FEM1C KIAA1785 Homo sapiens (Human) 617 protein ubiquitination [GO:0016567] GO:0005654; GO:0005737; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796; Q9CPW7 CHOYP_LOC100371628.1.1 m.35401 sp ZMAT2_MOUSE 72.727 198 50 3 2 198 3 197 4.64E-83 247 ZMAT2_MOUSE reviewed Zinc finger matrin-type protein 2 Zmat2 Mus musculus (Mouse) 199 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003677; GO:0003723; GO:0008270; GO:0046540 0 0 0 PF12171; Q9HU55 CHOYP_LOC593247.1.1 m.56872 sp GLRX_PSEAE 45.679 81 43 1 7 87 4 83 4.64E-17 79.3 GLRX_PSEAE reviewed Glutaredoxin grx PA5129 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 84 cell redox homeostasis [GO:0045454] GO:0005737; GO:0009055; GO:0015035; GO:0045454 0 0 cd03418; PF00462; Q9NUV9 CHOYP_LOC100331109.2.2 m.51774 sp GIMA4_HUMAN 41.176 272 141 4 77 346 27 281 4.64E-63 208 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9UKT8 CHOYP_FBXW2.1.1 m.7183 sp FBXW2_HUMAN 24.125 514 317 18 3 503 1 454 4.64E-31 128 FBXW2_HUMAN reviewed F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6) FBXW2 FBW2 FWD2 Homo sapiens (Human) 454 cellular protein modification process [GO:0006464]; proteolysis [GO:0006508] GO:0004842; GO:0006464; GO:0006508 0 0 0 PF12937;PF00400; Q9UMZ2 CHOYP_LOC588932.3.3 m.35464 sp SYNRG_HUMAN 44.712 208 103 1 1228 1423 1107 1314 4.64E-51 201 SYNRG_HUMAN reviewed Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) SYNRG AP1GBP1 SYNG Homo sapiens (Human) 1314 endocytosis [GO:0006897]; intracellular protein transport [GO:0006886] GO:0005737; GO:0005794; GO:0006886; GO:0006897; GO:0030121 0 0 0 0 Q9Z2U1 CHOYP_NEMVEDRAFT_V1G168163.1.1 m.63148 sp PSA5_MOUSE 79.325 237 49 0 1 237 1 237 4.64E-144 405 PSA5_MOUSE reviewed Proteasome subunit alpha type-5 (EC 3.4.25.1) (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain) Psma5 Mus musculus (Mouse) 241 "antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0000502; GO:0002479; GO:0004298; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005839; GO:0006511; GO:0019773; GO:0070062 0 0 0 PF00227;PF10584; D2GXS7 CHOYP_PHUM_PHUM559420.1.1 m.8620 sp TRIM2_AILME 23.922 255 154 5 59 296 20 251 4.65E-16 84 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O12947 CHOYP_LOC101174897.1.1 m.8891 sp ICMT_XENLA 51.916 287 131 1 18 304 4 283 4.65E-101 301 ICMT_XENLA reviewed Protein-S-isoprenylcysteine O-methyltransferase (EC 2.1.1.100) (Farnesyl cysteine carboxyl methyltransferase) (FCMT) (Isoprenylcysteine carboxylmethyltransferase) (Prenylated protein carboxyl methyltransferase) (PPMT) (Prenylcysteine carboxyl methyltransferase) (pcCMT) icmt Xenopus laevis (African clawed frog) 288 0 GO:0004671; GO:0005789; GO:0016021 0 0 0 PF04140; O75382 CHOYP_BRAFLDRAFT_87325.8.11 m.32733 sp TRIM3_HUMAN 23.358 274 171 12 152 404 489 744 4.65E-10 65.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P36873 CHOYP_LOC100378725.1.1 m.32308 sp PP1G_HUMAN 71.523 302 85 1 5 305 7 308 4.65E-166 467 PP1G_HUMAN reviewed Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) PPP1CC Homo sapiens (Human) 323 cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; neuron differentiation [GO:0030182]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of nucleocytoplasmic transport [GO:0046822]; sister chromatid cohesion [GO:0007062] GO:0000777; GO:0004721; GO:0004722; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0005925; GO:0005977; GO:0006470; GO:0007062; GO:0016607; GO:0016791; GO:0019901; GO:0030182; GO:0030496; GO:0032154; GO:0032922; GO:0042752; GO:0043153; GO:0043197; GO:0043234; GO:0044822; GO:0046822; GO:0046872; GO:0047485; GO:0051301; GO:0070688; GO:0072357 0 0 0 PF00149;PF16891; P48147 CHOYP_LOC584505.1.1 m.40580 sp PPCE_HUMAN 61.538 130 49 1 1 129 229 358 4.65E-51 174 PPCE_HUMAN reviewed Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) PREP PEP Homo sapiens (Human) 710 proteolysis [GO:0006508] GO:0004252; GO:0005634; GO:0005737; GO:0006508; GO:0008236; GO:0016020; GO:0070008 0 0 0 PF00326;PF02897; P91943 CHOYP_LOC100161896.1.1 m.26199 sp PANG1_DROME 50.667 300 117 12 14 291 99 389 4.65E-74 244 PANG1_DROME reviewed "Protein pangolin, isoforms A/H/I/S (dTCF)" pan TCF CG34403 Drosophila melanogaster (Fruit fly) 751 "embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; imaginal disc-derived wing morphogenesis [GO:0007476]; mesodermal cell fate determination [GO:0007500]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of hemocyte differentiation [GO:0045610]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription, DNA-templated [GO:0006355]; regulation of Wnt signaling pathway [GO:0030111]; salivary gland morphogenesis [GO:0007435]; segment polarity determination [GO:0007367]; spiracle morphogenesis, open tracheal system [GO:0035277]; transcription from RNA polymerase II promoter [GO:0006366]; Wnt signaling pathway [GO:0016055]" GO:0003705; GO:0005634; GO:0005667; GO:0005875; GO:0006355; GO:0006366; GO:0007367; GO:0007435; GO:0007476; GO:0007500; GO:0007507; GO:0009880; GO:0010628; GO:0016055; GO:0019900; GO:0030111; GO:0030178; GO:0035277; GO:0043565; GO:0045610; GO:0045892; GO:0045893; GO:0045944; GO:0070491; GO:0072091 0 0 0 PF08347;PF00505; Q02357 CHOYP_AAEL_AAEL014741.1.2 m.15148 sp ANK1_MOUSE 41.071 112 65 1 206 317 652 762 4.65E-16 82.4 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q14162 CHOYP_LOAG_07472.2.2 m.37525 sp SREC_HUMAN 32.014 278 149 15 181 429 104 370 4.65E-20 97.8 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q29RK9 CHOYP_MOB3B.1.2 m.19365 sp MOB3B_BOVIN 72.115 208 58 0 5 212 9 216 4.65E-121 345 MOB3B_BOVIN reviewed MOB kinase activator 3B (Mob1 homolog 2b) (Mps one binder kinase activator-like 2B) MOB3B MOBKL2B Bos taurus (Bovine) 216 0 GO:0046872 0 0 0 PF03637; Q3SZW1 CHOYP_BRAFLDRAFT_58823.1.1 m.49123 sp TSSK1_BOVIN 44.118 272 148 3 16 285 4 273 4.65E-78 244 TSSK1_BOVIN reviewed Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) TSSK1B TSSK1 Bos taurus (Bovine) 367 intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286] GO:0001669; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007275; GO:0007286; GO:0031514; GO:0035556; GO:0046872 0 0 0 PF00069; Q4QR06 CHOYP_BRAFLDRAFT_126225.1.1 m.23535 sp PCGF1_XENLA 55.469 128 57 0 1 128 47 174 4.65E-46 153 PCGF1_XENLA reviewed Polycomb group RING finger protein 1 pcgf1 Xenopus laevis (African clawed frog) 259 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0008270; GO:0031519 0 0 0 PF16207; Q5BK24 CHOYP_CH076.1.1 m.32283 sp CH076_RAT 36.923 130 79 2 17 145 8 135 4.65E-17 80.1 CH076_RAT reviewed Uncharacterized protein C8orf76 homolog 0 Rattus norvegicus (Rat) 374 0 0 0 0 0 0 Q5FWF4 CHOYP_ZRANB3.1.1 m.17041 sp ZRAB3_HUMAN 39.687 703 362 13 28 722 29 677 4.65E-162 516 ZRAB3_HUMAN reviewed DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)] ZRANB3 Homo sapiens (Human) 1079 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; DNA rewinding [GO:0036292]; negative regulation of DNA recombination [GO:0045910]; replication fork processing [GO:0031297]; replication fork protection [GO:0048478]; response to UV [GO:0009411] GO:0004386; GO:0004520; GO:0005524; GO:0005634; GO:0006281; GO:0006974; GO:0008270; GO:0009411; GO:0031297; GO:0036292; GO:0036310; GO:0043596; GO:0045910; GO:0048478; GO:0070530 0 0 0 PF00271;PF01844;PF00176;PF00641; Q61824 CHOYP_LOC100883390.1.1 m.32052 sp ADA12_MOUSE 39.434 459 248 11 5 455 304 740 4.65E-86 285 ADA12_MOUSE reviewed Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) Adam12 Mltna Mus musculus (Mouse) 903 cell adhesion [GO:0007155]; epidermal growth factor receptor signaling pathway [GO:0007173] GO:0004222; GO:0005654; GO:0005739; GO:0005886; GO:0007155; GO:0007173; GO:0008270; GO:0016021; GO:0017124 0 0 0 PF08516;PF00200;PF01562;PF01421; Q642H9 CHOYP_RS4.2.11 m.14952 sp RS4X_DANRE 77.778 135 30 0 4 138 3 137 4.65E-73 223 RS4X_DANRE reviewed "40S ribosomal protein S4, X isoform" rps4x rps4 zgc:92076 Danio rerio (Zebrafish) (Brachydanio rerio) 263 brain development [GO:0007420]; chordate embryonic development [GO:0043009]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0007420; GO:0019843; GO:0022627; GO:0043009 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q86MA7 CHOYP_PRQFV.2.2 m.56787 sp PRQFV_APLCA 36.364 209 92 9 35 206 481 685 4.65E-14 73.6 PRQFV_APLCA reviewed Protein PRQFV-amide [Cleaved into: AREFV-amide; PRQFV-amide (PRQFVa); VRDFV-amide; VREFV-amide; IREFV-amide] 0 Aplysia californica (California sea hare) 862 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 0 Q8IDX6 CHOYP_contig_014293 m.16336 sp RBP2A_PLAF7 41.985 131 58 4 646 763 2740 2865 4.65E-09 64.7 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8K0U4 CHOYP_BRAFLDRAFT_208293.8.20 m.40442 sp HS12A_MOUSE 32.377 244 155 5 20 255 421 662 4.65E-34 132 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q96GY3 CHOYP_LIN37.1.1 m.65960 sp LIN37_HUMAN 44.915 118 59 3 13 124 14 131 4.65E-21 90.1 LIN37_HUMAN reviewed Protein lin-37 homolog (Antolefinin) LIN37 MSTP064 Homo sapiens (Human) 246 cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726] GO:0005654; GO:0007049; GO:0017053; GO:0051726 0 0 0 PF15306; Q96MY1 CHOYP_LOC100376296.1.1 m.36837 sp NOL4L_HUMAN 45.37 324 91 9 223 522 175 436 4.65E-66 223 NOL4L_HUMAN reviewed Nucleolar protein 4-like NOL4L C20orf112 C20orf113 Homo sapiens (Human) 436 0 GO:0005654; GO:0005737 0 0 0 0 Q96RW7 CHOYP_NEMVEDRAFT_V1G88031.3.5 m.41305 sp HMCN1_HUMAN 49.153 59 30 0 195 253 4698 4756 4.65E-13 72.4 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99L04 CHOYP_DHRS1.1.1 m.57312 sp DHRS1_MOUSE 55.645 124 43 3 62 185 129 240 4.65E-37 133 DHRS1_MOUSE reviewed Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) Dhrs1 D14ertd484e Mus musculus (Mouse) 313 0 GO:0005739; GO:0005743; GO:0005783; GO:0016491 0 0 0 PF00106; A6QNR1 CHOYP_WDR92.1.1 m.12561 sp RRP36_BOVIN 40.826 218 126 1 83 297 26 243 4.66E-54 179 RRP36_BOVIN reviewed Ribosomal RNA processing protein 36 homolog RRP36 Bos taurus (Bovine) 246 cleavage involved in rRNA processing [GO:0000469]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364] GO:0000469; GO:0005730; GO:0006364; GO:0042274 0 0 0 PF06102; G5ED84 CHOYP_BACH1.5.17 m.11470 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 4.66E-11 69.7 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O70277 CHOYP_BRAFLDRAFT_87279.3.10 m.20516 sp TRIM3_RAT 29.008 131 83 5 65 186 614 743 4.66E-07 53.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_TRIM3.43.58 m.47063 sp TRIM3_RAT 24.8 250 163 13 85 320 465 703 4.66E-09 61.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_BRAFLDRAFT_224574.18.18 m.65591 sp MEGF6_HUMAN 39.6 250 136 9 8 255 750 986 4.66E-34 133 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P01130 CHOYP_LOC100366813.3.6 m.21332 sp LDLR_HUMAN 59.091 66 26 1 40 104 80 145 4.66E-19 84 LDLR_HUMAN reviewed Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899] GO:0001618; GO:0001948; GO:0002020; GO:0004872; GO:0005041; GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005887; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0008203; GO:0009897; GO:0009986; GO:0010008; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0030669; GO:0032050; GO:0034362; GO:0034383; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0070508; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P23508 CHOYP_contig_039932 m.45147 sp CRCM_HUMAN 43.705 842 386 18 192 977 20 829 4.66E-162 499 CRCM_HUMAN reviewed Colorectal mutant cancer protein (Protein MCC) MCC Homo sapiens (Human) 829 establishment of protein localization [GO:0045184]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055] GO:0004872; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007165; GO:0010633; GO:0016055; GO:0030027; GO:0045184; GO:0050680; GO:0090090 0 0 0 PF10506; P55906 CHOYP_ANT_25430.2.2 m.5862 sp BGH3_BOVIN 29.965 287 176 9 20 303 379 643 4.66E-23 102 BGH3_BOVIN reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (MP70) (MP78) TGFBI BIGH3 Bos taurus (Bovine) 683 cell adhesion [GO:0007155]; cell proliferation [GO:0008283] GO:0005578; GO:0007155; GO:0008283; GO:0050840 0 0 0 PF02469; P57756 CHOYP_FGL2.9.9 m.64396 sp FCN2_RAT 47.98 198 101 2 89 285 123 319 4.66E-54 181 FCN2_RAT reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Rattus norvegicus (Rat) 319 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0033691; GO:0046872 0 0 0 PF01391;PF00147; Q3ZBG9 CHOYP_contig_045072 m.52344 sp PLS2_BOVIN 58.582 268 98 5 1 258 24 288 4.66E-105 310 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q3ZBY7 CHOYP_LOC100378209.2.2 m.9142 sp DEGS1_BOVIN 50 320 158 2 13 330 4 323 4.66E-115 338 DEGS1_BOVIN reviewed Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Degenerative spermatocyte homolog 1) DEGS1 DES1 Bos taurus (Bovine) 323 ceramide biosynthetic process [GO:0046513]; fatty acid biosynthetic process [GO:0006633] GO:0005739; GO:0005789; GO:0006633; GO:0016021; GO:0042284; GO:0046513 0 0 0 PF00487;PF08557; Q5RBZ3 CHOYP_WDR89.1.1 m.30861 sp WDR89_PONAB 37.536 349 190 11 29 354 22 365 4.66E-70 227 WDR89_PONAB reviewed WD repeat-containing protein 89 WDR89 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 387 0 0 0 0 0 PF00400; Q6H236 CHOYP_contig_050507 m.60115 sp PEG3_BOVIN 33.054 239 160 0 194 432 1301 1539 4.66E-16 84.7 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6NRG6 CHOYP_LOC100376181.1.1 m.45757 sp SAS6_XENLA 45.072 690 326 12 1 665 1 662 4.66E-178 525 SAS6_XENLA reviewed Spindle assembly abnormal protein 6 homolog sas6 Xenopus laevis (African clawed frog) 668 centriole replication [GO:0007099] GO:0005814; GO:0007099; GO:0098536 0 0 0 PF16531; Q6P011 CHOYP_BRAFLDRAFT_126700.2.2 m.52266 sp EMC4_DANRE 54.438 169 73 3 16 182 21 187 4.66E-62 193 EMC4_DANRE reviewed ER membrane protein complex subunit 4 (Transmembrane protein 85) emc4 tmem85 zgc:77852 Danio rerio (Zebrafish) (Brachydanio rerio) 189 0 GO:0016021; GO:0072546 0 0 0 PF06417; Q8BRH4 CHOYP_LOC591084.2.2 m.59355 sp KMT2C_MOUSE 35.854 820 423 23 893 1651 917 1694 4.66E-130 466 KMT2C_MOUSE reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog) Kmt2c Mll3 Mus musculus (Mouse) 4903 "eyelid development in camera-type eye [GO:0061029]; histone methylation [GO:0016571]; multicellular organism growth [GO:0035264]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; single fertilization [GO:0007338]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0007338; GO:0008270; GO:0010468; GO:0016571; GO:0016746; GO:0035097; GO:0035264; GO:0042800; GO:0044666; GO:0044822; GO:0048146; GO:0061029 0 0 0 PF05965;PF05964;PF00628;PF00856; Q8JHV9 CHOYP_BIRC3.4.7 m.42631 sp BIR7A_XENLA 32.796 372 223 6 704 1062 43 400 4.66E-62 220 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8N2E2 CHOYP_BRAFLDRAFT_80496.1.10 m.12618 sp VWDE_HUMAN 24.919 309 199 9 2262 2553 802 1094 4.66E-17 92.4 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TCT0 CHOYP_CERKL.2.4 m.35013 sp CERK1_HUMAN 30.682 264 174 4 38 294 50 311 4.66E-36 143 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q96MM6 CHOYP_BRAFLDRAFT_240123.1.6 m.5028 sp HS12B_HUMAN 27.002 637 379 19 13 580 61 680 4.66E-67 234 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q98925 CHOYP_IRF2.2.2 m.57680 sp IRF2_CHICK 53.39 118 52 2 19 133 2 119 4.66E-39 145 IRF2_CHICK reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) 348 cell proliferation [GO:0008283] GO:0000977; GO:0001228; GO:0005654; GO:0005737; GO:0005925; GO:0008283 0 0 0 PF00605; Q9ESN6 CHOYP_BRAFLDRAFT_88223.11.22 m.42423 sp TRIM2_MOUSE 25.735 272 178 12 219 478 483 742 4.66E-14 78.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9I8C7 CHOYP_LOAG_04698.1.2 m.2834 sp ACH10_CHICK 47.148 263 139 0 24 286 33 295 4.66E-95 290 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9NZ09 CHOYP_LOC594675.1.1 m.41173 sp UBAP1_HUMAN 37.815 119 71 1 510 625 379 497 4.66E-16 84.7 UBAP1_HUMAN reviewed Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) UBAP1 NAG20 Homo sapiens (Human) 502 protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] GO:0000813; GO:0005737; GO:0005794; GO:0005829; GO:0005886; GO:0015031; GO:0043130; GO:0043162 0 0 0 0 A0JPI9 CHOYP_LOC582270.1.2 m.9924 sp LR74A_RAT 28.54 452 294 8 18 446 21 466 4.67E-51 184 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A2BGT0 CHOYP_LOC100377876.2.2 m.50405 sp UBP30_DANRE 42.063 126 66 2 150 268 59 184 4.67E-21 95.9 UBP30_DANRE reviewed Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) usp30 si:dkey-72n1.2 Danio rerio (Zebrafish) (Brachydanio rerio) 491 mitochondrial fusion [GO:0008053]; mitophagy [GO:0000422]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000422; GO:0004197; GO:0004843; GO:0005739; GO:0005741; GO:0006511; GO:0008053; GO:0016021; GO:0016579; GO:0035871; GO:0044313 0 0 0 PF00443; A4IF63 CHOYP_BRAFLDRAFT_255103.2.18 m.20658 sp TRIM2_BOVIN 25.175 143 102 3 50 188 602 743 4.67E-08 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_69798.10.22 m.42035 sp TRIM2_BOVIN 24.476 143 107 1 30 172 602 743 4.67E-07 52.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6BM72 CHOYP_LOC579946.22.24 m.58721 sp MEG11_HUMAN 38.172 186 103 8 37 220 352 527 4.67E-23 101 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; E7EY42 CHOYP_LOC101080052.1.1 m.46060 sp PTSS2_DANRE 35.294 102 63 2 1 100 351 451 4.67E-12 63.9 PTSS2_DANRE reviewed Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II) ptdss2 si:ch1073-158c2 si:ch1073-279O1 Danio rerio (Zebrafish) (Brachydanio rerio) 452 phosphatidylserine biosynthetic process [GO:0006659]; phospholipid biosynthetic process [GO:0008654] GO:0005789; GO:0006659; GO:0008654; GO:0016021; GO:0016740 PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis. 0 0 PF03034; O89044 CHOYP_LOC100378741.1.1 m.13264 sp PRI2_RAT 51.163 473 221 6 57 523 24 492 4.67E-172 499 PRI2_RAT reviewed DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58) Prim2 Rattus norvegicus (Rat) 507 DNA replication [GO:0006260] GO:0003677; GO:0003896; GO:0006260; GO:0046872; GO:0051539; GO:1990077 0 0 cd07322; PF04104; P08953 CHOYP_LOC100745429.1.1 m.27819 sp TOLL_DROME 23.454 388 260 18 9 381 631 996 4.67E-11 68.2 TOLL_DROME reviewed Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) 1097 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cell adhesion [GO:0007155]; defense response [GO:0006952]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; dorsal/ventral axis specification [GO:0009950]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; mitotic cytokinesis [GO:0000281]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; regulation of hemocyte differentiation [GO:0045610]; regulation of melanization defense response [GO:0035007]; response to bacterium [GO:0009617]; response to fungus [GO:0009620]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]; zygotic specification of dorsal/ventral axis [GO:0007352] GO:0000281; GO:0002229; GO:0004888; GO:0005737; GO:0005769; GO:0005886; GO:0006952; GO:0006955; GO:0006963; GO:0006967; GO:0007155; GO:0007352; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009617; GO:0009620; GO:0009880; GO:0009897; GO:0009950; GO:0009986; GO:0016021; GO:0016201; GO:0019730; GO:0019732; GO:0019955; GO:0030097; GO:0032154; GO:0035007; GO:0035172; GO:0042802; GO:0043234; GO:0045087; GO:0045610; GO:0045944; GO:0050830; GO:0050832; GO:0070976; GO:1902875 0 0 0 PF00560;PF13306;PF13855;PF01462;PF01582; P16157 CHOYP_AFUA_1G01020.40.50 m.61385 sp ANK1_HUMAN 38.188 309 191 0 2 310 289 597 4.67E-52 187 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20478 CHOYP_BRAFLDRAFT_124935.1.1 m.65455 sp GLNA2_DROME 75.691 181 44 0 74 254 102 282 4.67E-105 312 GLNA2_DROME reviewed Glutamine synthetase 2 cytoplasmic (EC 6.3.1.2) (Glutamate--ammonia ligase 2) Gs2 CG1743 Drosophila melanogaster (Fruit fly) 369 glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; neurotransmitter receptor metabolic process [GO:0045213]; synapse assembly [GO:0007416] GO:0004356; GO:0005524; GO:0005737; GO:0006538; GO:0006542; GO:0007416; GO:0045213 0 0 0 PF00120;PF03951; P22105 CHOYP_MEGF6.35.59 m.42904 sp TENX_HUMAN 29.362 596 298 48 166 721 235 747 4.67E-32 138 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P27085 CHOYP_RS26.7.15 m.30831 sp RS26_OCTVU 86.957 115 13 1 19 131 1 115 4.67E-69 207 RS26_OCTVU reviewed 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) 127 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01283; P30170 CHOYP_A1.1.1 m.38444 sp ACT10_SOLTU 55.405 148 43 2 1 148 64 188 4.67E-38 132 ACT10_SOLTU reviewed Actin-85C (Fragment) AC85C Solanum tuberosum (Potato) 195 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q4I963 CHOYP_CHGG_10233.1.1 m.39238 sp COFI_GIBZE 39.007 141 84 1 3 141 4 144 4.67E-30 109 COFI_GIBZE reviewed Cofilin (Actin-depolymerizing factor 1) COF1 FGRRES_06245 FGSG_06245 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) 153 actin filament depolymerization [GO:0030042]; actin filament severing [GO:0051014]; cell cycle [GO:0007049]; cell division [GO:0051301]; endocytosis [GO:0006897]; Golgi to plasma membrane protein transport [GO:0043001] GO:0006897; GO:0007049; GO:0016363; GO:0030042; GO:0030479; GO:0043001; GO:0051014; GO:0051301 0 0 cd11286; PF00241; Q5RE11 CHOYP_TSN3.1.1 m.57074 sp TSN3_PONAB 37.879 264 139 9 1 250 1 253 4.67E-47 159 TSN3_PONAB reviewed Tetraspanin-3 (Tspan-3) TSPAN3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 253 0 GO:0016021; GO:0070062 0 0 0 PF00335; Q7Z5P9 CHOYP_BRAFLDRAFT_139244.1.2 m.42173 sp MUC19_HUMAN 30.769 221 139 3 65 273 4362 4580 4.67E-08 57.8 MUC19_HUMAN reviewed Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) 8384 O-glycan processing [GO:0016266] GO:0005796; GO:0016266; GO:0070062 0 0 0 PF08742;PF01826;PF00094; Q86Y82 CHOYP_STX12.1.1 m.34092 sp STX12_HUMAN 37.638 271 132 5 11 260 3 257 4.67E-49 166 STX12_HUMAN reviewed Syntaxin-12 STX12 Homo sapiens (Human) 276 autophagosome assembly [GO:0000045]; cholesterol efflux [GO:0033344]; intracellular protein transport [GO:0006886]; protein stabilization [GO:0050821]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000045; GO:0000139; GO:0000149; GO:0000407; GO:0005484; GO:0006886; GO:0006906; GO:0010008; GO:0012505; GO:0016021; GO:0031201; GO:0031982; GO:0033344; GO:0045121; GO:0045335; GO:0048278; GO:0050821; GO:0070062 0 0 0 PF05739; Q8CBW3 CHOYP_LOC100372094.1.1 m.16453 sp ABI1_MOUSE 50.622 241 97 6 1 233 1 227 4.67E-66 222 ABI1_MOUSE reviewed Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1) Abi1 Ssh3bp1 Mus musculus (Mouse) 481 dendrite morphogenesis [GO:0048813]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; peptidyl-tyrosine phosphorylation [GO:0018108]; somitogenesis [GO:0001756] GO:0001756; GO:0005622; GO:0005634; GO:0005856; GO:0014069; GO:0018108; GO:0030027; GO:0030054; GO:0030175; GO:0030296; GO:0030426; GO:0031209; GO:0031252; GO:0032403; GO:0035855; GO:0043005; GO:0045211; GO:0048813; GO:0070062; GO:0072673 0 0 0 PF07815;PF00018; Q8NB46 CHOYP_LOC101246844.1.1 m.43148 sp ANR52_HUMAN 33.333 165 109 1 9 172 147 311 4.67E-16 86.7 ANR52_HUMAN reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) (Ankyrin repeat domain-containing protein 52) ANKRD52 Homo sapiens (Human) 1076 0 0 0 0 0 PF00023;PF12796; Q96EV8 CHOYP_DTNBP1.1.1 m.66644 sp DTBP1_HUMAN 29.261 352 195 7 18 323 1 344 4.67E-31 123 DTBP1_HUMAN reviewed Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein) DTNBP1 BLOC1S8 My031 Homo sapiens (Human) 351 actin cytoskeleton reorganization [GO:0031532]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; melanosome organization [GO:0032438]; neuron projection development [GO:0031175]; neuron projection morphogenesis [GO:0048812]; platelet dense granule organization [GO:0060155]; positive regulation of gene expression [GO:0010628]; positive regulation of neurotransmitter secretion [GO:0001956]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of dopamine secretion [GO:0014059]; regulation of JUN kinase activity [GO:0043506] GO:0001956; GO:0005634; GO:0005737; GO:0005789; GO:0005829; GO:0007596; GO:0008089; GO:0010008; GO:0010628; GO:0014059; GO:0014069; GO:0016528; GO:0030054; GO:0030424; GO:0030426; GO:0030672; GO:0031083; GO:0031175; GO:0031532; GO:0032438; GO:0033162; GO:0042383; GO:0043005; GO:0043197; GO:0043506; GO:0045211; GO:0048490; GO:0048812; GO:0060155; GO:0060159; GO:1904115 0 0 0 PF04440; Q99315 CHOYP_contig_028266 m.32186 sp YG31B_YEAST 42.5 120 65 3 128 245 576 693 4.67E-18 86.7 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9NG98 CHOYP_TOP3A.2.2 m.27358 sp TOP3A_DROME 45.098 102 54 2 24 124 1145 1245 4.67E-20 87.8 TOP3A_DROME reviewed DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha) Top3alpha CG10123 Drosophila melanogaster (Fruit fly) 1250 developmental growth [GO:0048589]; DNA topological change [GO:0006265]; double-strand break repair via homologous recombination [GO:0000724]; mitochondrial genome maintenance [GO:0000002]; tissue regeneration [GO:0042246] GO:0000002; GO:0000724; GO:0003677; GO:0003916; GO:0003917; GO:0005634; GO:0005694; GO:0005739; GO:0005829; GO:0006265; GO:0008270; GO:0042246; GO:0048589 0 0 cd00186; PF01131;PF01751;PF01396;PF06839; A2AS55 CHOYP_LOC100888817.1.1 m.23680 sp ANR16_MOUSE 46.25 320 170 2 31 348 36 355 4.68E-84 261 ANR16_MOUSE reviewed Ankyrin repeat domain-containing protein 16 Ankrd16 Mus musculus (Mouse) 361 0 0 0 0 0 PF00023;PF12796; B3EWY9 CHOYP_contig_017085 m.20087 sp MLP_ACRMI 27.809 1068 618 38 143 1147 388 1365 4.68E-97 350 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O43301 CHOYP_BRAFLDRAFT_208293.19.20 m.65910 sp HS12A_HUMAN 29.553 291 195 4 34 316 385 673 4.68E-33 132 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75445 CHOYP_USH2A.2.6 m.10177 sp USH2A_HUMAN 37.135 377 229 3 16 384 2489 2865 4.68E-77 263 USH2A_HUMAN reviewed Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF02210;PF00055; O75581 CHOYP_LRP1B.1.2 m.7346 sp LRP6_HUMAN 26.697 869 583 27 132 983 100 931 4.68E-74 274 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; P35353 CHOYP_CRHR.2.2 m.41306 sp CRFR1_RAT 43.425 327 163 8 99 421 30 338 4.68E-79 253 CRFR1_RAT reviewed Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1) Crhr1 Crhr Rattus norvegicus (Rat) 415 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; adrenal gland development [GO:0030325]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; behavioral response to pain [GO:0048266]; cell surface receptor signaling pathway [GO:0007166]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; corticotropin secretion [GO:0051458]; epithelial cell differentiation [GO:0030855]; fear response [GO:0042596]; feeding behavior [GO:0007631]; general adaptation syndrome, behavioral process [GO:0051867]; hypothalamus development [GO:0021854]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of feeding behavior [GO:2000252]; negative regulation of neuron death [GO:1901215]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of mast cell degranulation [GO:0043306]; regulation of corticosterone secretion [GO:2000852]; regulation of synaptic plasticity [GO:0048167]; response to electrical stimulus [GO:0051602]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; visual learning [GO:0008542]" GO:0001666; GO:0001965; GO:0004930; GO:0005771; GO:0005802; GO:0005886; GO:0007166; GO:0007188; GO:0007189; GO:0007200; GO:0007204; GO:0007218; GO:0007613; GO:0007631; GO:0008542; GO:0010579; GO:0015056; GO:0016020; GO:0016021; GO:0021854; GO:0030325; GO:0030425; GO:0030819; GO:0030855; GO:0031226; GO:0031982; GO:0032403; GO:0032811; GO:0035641; GO:0035902; GO:0042277; GO:0042596; GO:0043025; GO:0043306; GO:0043404; GO:0045177; GO:0048148; GO:0048149; GO:0048167; GO:0048266; GO:0051424; GO:0051458; GO:0051602; GO:0051867; GO:0060291; GO:0071376; GO:1901215; GO:2000252; GO:2000852 0 0 0 PF00002;PF02793; P62083 CHOYP_RS7.9.9 m.66215 sp RS7_RAT 84.783 184 26 2 1 182 1 184 4.68E-110 315 RS7_RAT reviewed 40S ribosomal protein S7 (S8) Rps7 Rattus norvegicus (Rat) 194 ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0003735; GO:0005815; GO:0006364; GO:0006412; GO:0008266; GO:0022627; GO:0030686; GO:0032040; GO:0042274 0 0 0 PF01251; P98187 CHOYP_BRAFLDRAFT_61250.4.14 m.20200 sp CP4F8_HUMAN 39.173 508 287 10 26 521 19 516 4.68E-121 368 CP4F8_HUMAN reviewed Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016021; GO:0018685; GO:0019825; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q17QJ5 CHOYP_LOC101157787.1.1 m.24321 sp TSN5_BOVIN 57.447 94 39 1 13 105 3 96 4.68E-30 111 TSN5_BOVIN reviewed Tetraspanin-5 (Tspan-5) TSPAN5 Bos taurus (Bovine) 268 cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007166; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q40251 CHOYP_VDE.1.1 m.30310 sp VDE_LACSA 26.165 279 189 8 10 278 97 368 4.68E-22 98.6 VDE_LACSA reviewed "Violaxanthin de-epoxidase, chloroplastic (EC 1.23.5.1)" VDE1 Lactuca sativa (Garden lettuce) 473 0 GO:0009535; GO:0046422 0 0 0 PF07137; Q4UMH6 CHOYP_TVAG_291510.5.9 m.22920 sp Y381_RICFE 29.646 226 150 6 28 252 872 1089 4.68E-19 93.2 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q4ZJM9 CHOYP_CBLN3.1.2 m.29254 sp C1QL4_MOUSE 34.127 126 75 3 254 371 110 235 4.68E-12 68.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8SWR3 CHOYP_DVIR_GJ18645.1.1 m.55503 sp SPR_DROME 28.652 356 226 8 88 417 50 403 4.68E-42 157 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q91584 CHOYP_LOC100533384.1.5 m.266 sp ELAV3_XENLA 51.19 84 41 0 30 113 259 342 4.68E-21 89 ELAV3_XENLA reviewed ELAV-like protein 3 (Protein ElrC) elavl3 elrC Xenopus laevis (African clawed frog) 348 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0000166; GO:0003723; GO:0007399; GO:0030154; GO:0030529 0 0 0 PF00076; Q9CZJ2 CHOYP_HS12A.24.33 m.60051 sp HS12B_MOUSE 35.008 637 336 15 7 579 61 683 4.68E-109 344 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9N2N6 CHOYP_LOC373275.4.7 m.47555 sp TBB_EUPFO 91.667 60 5 0 1 60 1 60 4.68E-36 129 TBB_EUPFO reviewed Tubulin beta chain (Beta-tubulin) 0 Euplotes focardii 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; A4IF63 CHOYP_BRAFLDRAFT_69765.3.23 m.8073 sp TRIM2_BOVIN 38.095 84 48 3 29 111 627 707 4.69E-08 53.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5D6U8 CHOYP_LOC100370821.2.2 m.45409 sp ACP7_DANRE 37.642 441 227 12 23 440 24 439 4.69E-84 272 ACP7_DANRE reviewed Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form) acp7 papl zgc:162913 Danio rerio (Zebrafish) (Brachydanio rerio) 443 0 GO:0003993; GO:0005576; GO:0046872 0 0 0 PF00149;PF14008;PF16656; B2RXR6 CHOYP_TVAG_067900.4.7 m.32555 sp ANR44_MOUSE 31.429 175 102 4 63 237 212 368 4.69E-17 83.2 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; D2KQB0 CHOYP_HHEX.2.2 m.19528 sp HHEX_PATMI 44.138 290 132 8 15 289 2 276 4.69E-62 200 HHEX_PATMI reviewed Hematopoietically-expressed homeobox protein HHEX homolog (AmHEX) (Homeobox protein HEX) (HEX homeodomain transcription factor) hhex hex Patiria miniata (Bat star) (Asterina miniata) 280 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; E1BD59 CHOYP_LOC100376307.1.2 m.13285 sp TRI56_BOVIN 24.068 295 191 11 16 296 20 295 4.69E-12 72.8 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O54941 CHOYP_LOC100651274.1.1 m.26220 sp SMCE1_MOUSE 46.032 378 159 8 94 467 70 406 4.69E-90 288 SMCE1_MOUSE reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) (BAF57) Smarce1 Baf57 Mus musculus (Mouse) 411 "ATP-dependent chromatin remodeling [GO:0043044]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; negative regulation of transcription, DNA-templated [GO:0045892]; neurogenesis [GO:0022008]; nucleosome disassembly [GO:0006337]" GO:0000790; GO:0000978; GO:0000980; GO:0003723; GO:0005634; GO:0005654; GO:0006337; GO:0006338; GO:0008080; GO:0016514; GO:0016569; GO:0016922; GO:0017053; GO:0022008; GO:0043044; GO:0043234; GO:0045892; GO:0047485; GO:0071564; GO:0071565; GO:0090544 0 0 0 PF00505; O70277 CHOYP_BRAFLDRAFT_87327.5.13 m.39240 sp TRIM3_RAT 28.333 120 81 3 37 152 625 743 4.69E-08 56.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_LOC753709.38.44 m.63822 sp ANR17_HUMAN 36.519 293 176 8 7 291 367 657 4.69E-39 149 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O97237 CHOYP_FUTSC.3.4 m.18545 sp YGCC1_PLAF7 20 135 108 0 698 832 230 364 4.69E-08 62 YGCC1_PLAF7 reviewed GRIP and coiled-coil domain-containing protein PFC0235w PFC0235w Plasmodium falciparum (isolate 3D7) 1139 protein targeting to Golgi [GO:0000042] GO:0000042; GO:0005622 0 0 0 0 P10079 CHOYP_AGAP_AGAP002739.1.5 m.19925 sp FBP1_STRPU 36.157 661 363 21 1741 2389 321 934 4.69E-92 330 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P19021 CHOYP_AGAP_AGAP007420.1.1 m.19854 sp AMD_HUMAN 51.111 90 42 2 21 109 244 332 4.69E-23 97.1 AMD_HUMAN reviewed Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)] PAM Homo sapiens (Human) 973 central nervous system development [GO:0007417]; heart development [GO:0007507]; lactation [GO:0007595]; limb development [GO:0060173]; long-chain fatty acid metabolic process [GO:0001676]; maternal process involved in female pregnancy [GO:0060135]; odontogenesis [GO:0042476]; ovulation cycle process [GO:0022602]; peptide amidation [GO:0001519]; protein amidation [GO:0018032]; protein homooligomerization [GO:0051260]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of protein secretion [GO:0050708]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to pH [GO:0009268]; toxin metabolic process [GO:0009404] GO:0001519; GO:0001666; GO:0001676; GO:0004504; GO:0004598; GO:0005507; GO:0005509; GO:0005615; GO:0005802; GO:0005886; GO:0006357; GO:0007417; GO:0007507; GO:0007595; GO:0008270; GO:0009268; GO:0009404; GO:0009986; GO:0016020; GO:0016021; GO:0018032; GO:0022602; GO:0030667; GO:0031418; GO:0032355; GO:0032956; GO:0042476; GO:0042493; GO:0043005; GO:0043204; GO:0046688; GO:0048471; GO:0050708; GO:0051260; GO:0051384; GO:0060135; GO:0060173; GO:0070062 0 0 0 PF03712;PF01082;PF01436; P55326 CHOYP_LOC100878467.3.4 m.12313 sp YZG1_CAEEL 33.708 178 95 4 53 230 22 176 4.69E-22 93.6 YZG1_CAEEL reviewed Uncharacterized protein F13E6.1 F13E6.1 Caenorhabditis elegans 195 0 0 0 0 0 PF04201; Q05481 CHOYP_ZFP62.1.1 m.10845 sp ZNF91_HUMAN 30.671 626 366 22 722 1328 240 816 4.69E-54 211 ZNF91_HUMAN reviewed Zinc finger protein 91 (Zinc finger protein HPF7) (Zinc finger protein HTF10) ZNF91 Homo sapiens (Human) 1191 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transposon integration [GO:0070895]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0008270; GO:0045892; GO:0070895 0 0 cd07765; PF01352;PF00096;PF13912; Q05932 CHOYP_BRAFLDRAFT_284412.1.1 m.37396 sp FOLC_HUMAN 45.061 577 281 8 7 572 30 581 4.69E-160 472 FOLC_HUMAN reviewed "Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)" FPGS Homo sapiens (Human) 587 brain development [GO:0007420]; cell proliferation [GO:0008283]; folic acid-containing compound metabolic process [GO:0006760]; folic acid metabolic process [GO:0046655]; glutamate metabolic process [GO:0006536]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; one-carbon metabolic process [GO:0006730]; organ regeneration [GO:0031100]; tetrahydrofolylpolyglutamate biosynthetic process [GO:0046901] GO:0001889; GO:0004326; GO:0005524; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0005829; GO:0006139; GO:0006536; GO:0006730; GO:0006760; GO:0007420; GO:0008283; GO:0031100; GO:0046655; GO:0046901 PATHWAY: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis. 0 0 0 Q09324 CHOYP_LOC100375210.2.3 m.4046 sp GCNT1_MOUSE 36.264 364 200 8 150 484 56 416 4.69E-72 238 GCNT1_MOUSE reviewed "Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT)" Gcnt1 Mus musculus (Mouse) 428 cell adhesion molecule production [GO:0060352]; glycoprotein biosynthetic process [GO:0009101]; kidney morphogenesis [GO:0060993]; leukocyte tethering or rolling [GO:0050901]; protein glycosylation [GO:0006486]; response to insulin [GO:0032868]; tissue morphogenesis [GO:0048729] GO:0000139; GO:0003829; GO:0005615; GO:0005802; GO:0006486; GO:0009101; GO:0016021; GO:0031985; GO:0032868; GO:0048729; GO:0050901; GO:0060352; GO:0060993 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02485; Q14162 CHOYP_CED1.21.29 m.46920 sp SREC_HUMAN 37.705 122 72 3 11 132 229 346 4.69E-15 80.1 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q2EMV9 CHOYP_PARP14.7.22 m.33684 sp PAR14_MOUSE 22.028 286 205 7 5 281 1322 1598 4.69E-08 57.8 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q6PFL6 CHOYP_LOC101165308.1.1 m.55646 sp CCD43_DANRE 43.415 205 109 4 24 223 11 213 4.69E-35 126 CCD43_DANRE reviewed Coiled-coil domain-containing protein 43 ccdc43 zgc:66277 Danio rerio (Zebrafish) (Brachydanio rerio) 213 0 0 0 0 0 0 Q8BYM7 CHOYP_AAEL_AAEL002456.1.1 m.35591 sp RSH4A_MOUSE 56.04 298 124 2 20 316 213 504 4.69E-97 328 RSH4A_MOUSE reviewed Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3) Rsph4a Rshl3 Mus musculus (Mouse) 716 axoneme assembly [GO:0035082]; cilium movement [GO:0003341] GO:0001534; GO:0003341; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005930; GO:0035082 0 0 0 PF04712; Q8CDF7 CHOYP_EGL.2.3 m.26662 sp EXD1_MOUSE 29.762 168 101 4 23 181 152 311 4.69E-11 68.6 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q8IXL7 CHOYP_MSRB3.3.4 m.18922 sp MSRB3_HUMAN 55.172 145 62 3 46 187 34 178 4.69E-55 176 MSRB3_HUMAN reviewed Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.-) MSRB3 UNQ1965/PRO4487 Homo sapiens (Human) 192 protein repair [GO:0030091]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005783; GO:0005829; GO:0006979; GO:0008270; GO:0030091; GO:0033743 0 0 0 PF01641; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.25.34 m.55918 sp VWDE_HUMAN 25.484 671 415 34 21 652 6 630 4.69E-20 100 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q90XW6 CHOYP_LOC100480673.1.1 m.10045 sp IRX4A_XENLA 42.5 280 84 10 5 236 120 370 4.69E-46 167 IRX4A_XENLA reviewed Iroquois-class homeodomain protein irx-4-A (Iroquois homeobox protein 4-A) irx4-a irx4 Xenopus laevis (African clawed frog) 496 "brain development [GO:0007420]; cell differentiation [GO:0030154]; dorsal/ventral pattern formation [GO:0009953]; heart development [GO:0007507]; proximal/distal pattern formation [GO:0009954]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007420; GO:0007507; GO:0009953; GO:0009954; GO:0030154; GO:0043565 0 0 0 PF05920; Q99M80 CHOYP_PTPRT.7.45 m.28350 sp PTPRT_MOUSE 31.181 728 427 17 694 1367 745 1452 4.69E-87 315 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BY67 CHOYP_UNC22.1.2 m.46930 sp CADM1_HUMAN 27.317 205 134 9 94 292 135 330 4.69E-09 61.6 CADM1_HUMAN reviewed Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1) CADM1 IGSF4 IGSF4A NECL2 SYNCAM TSLC1 Homo sapiens (Human) 442 adherens junction organization [GO:0034332]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell recognition [GO:0008037]; detection of stimulus [GO:0051606]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; immune system process [GO:0002376]; multicellular organism development [GO:0007275]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; spermatogenesis [GO:0007283]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271] GO:0002376; GO:0004872; GO:0005102; GO:0005886; GO:0005887; GO:0005911; GO:0005913; GO:0006915; GO:0007156; GO:0007157; GO:0007275; GO:0007283; GO:0008037; GO:0016323; GO:0030154; GO:0030165; GO:0034332; GO:0042271; GO:0042803; GO:0045202; GO:0045954; GO:0050715; GO:0050839; GO:0051606; GO:0070062 0 0 0 PF08205;PF07686; Q9H3E2 CHOYP_BRAFLDRAFT_79692.1.1 m.44918 sp SNX25_HUMAN 42.041 245 117 2 5 224 583 827 4.69E-61 207 SNX25_HUMAN reviewed Sorting nexin-25 SNX25 MSTP043 Homo sapiens (Human) 840 negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein transport [GO:0015031]; receptor catabolic process [GO:0032801] GO:0010008; GO:0015031; GO:0030512; GO:0032801; GO:0035091; GO:0060394 0 0 0 PF08628;PF00787;PF02194;PF00615; Q9Z2H2 CHOYP_AGAP_AGAP000232.1.1 m.1999 sp RGS6_MOUSE 38.876 445 233 10 11 431 21 450 4.69E-92 293 RGS6_MOUSE reviewed Regulator of G-protein signaling 6 (RGS6) Rgs6 Mus musculus (Mouse) 472 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547] GO:0004871; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005834; GO:0005886; GO:0007186; GO:0009968; GO:0019898; GO:0035556; GO:0043547 0 0 cd00068; PF00610;PF00631;PF00615; Q9ZPY2 CHOYP_LOC100206475.3.16 m.21125 sp LAC6_ARATH 29.63 162 72 4 29 186 446 569 4.69E-14 74.3 LAC6_ARATH reviewed Laccase-6 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 6) (Diphenol oxidase 6) (Urishiol oxidase 6) LAC6 At2g46570 F13A10.10 Arabidopsis thaliana (Mouse-ear cress) 569 lignin biosynthetic process [GO:0009809]; lignin catabolic process [GO:0046274] GO:0005507; GO:0009809; GO:0016722; GO:0046274; GO:0048046; GO:0052716 0 0 0 PF00394;PF07731;PF07732; A2VDN6 CHOYP_MGC80562.1.1 m.37827 sp SF3A1_BOVIN 68.376 117 37 0 87 203 677 793 4.70E-49 173 SF3A1_BOVIN reviewed Splicing factor 3A subunit 1 SF3A1 Bos taurus (Bovine) 793 "mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000381; GO:0000389; GO:0000398; GO:0003723; GO:0005654; GO:0005684; GO:0005686; GO:0044822; GO:0071004; GO:0071013 0 0 0 PF12230;PF01805;PF00240; A4IF63 CHOYP_LOC100373444.48.79 m.42233 sp TRIM2_BOVIN 28.761 226 140 7 339 554 530 744 4.70E-12 72.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O00370 CHOYP_LOC100368926.1.5 m.4696 sp LORF2_HUMAN 29.237 236 163 3 1 234 641 874 4.70E-23 105 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O88974 CHOYP_LOC100863269.1.1 m.16628 sp SETB1_MOUSE 44.156 385 204 7 236 609 573 957 4.70E-94 325 SETB1_MOUSE reviewed Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.43) (ERG-associated protein with SET domain) (ESET) (SET domain bifurcated 1) Setdb1 Eset Kiaa0067 Mus musculus (Mouse) 1307 "bone development [GO:0060348]; histone H3-K9 trimethylation [GO:0036124]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; Ras protein signal transduction [GO:0007265]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001833; GO:0003677; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005886; GO:0006351; GO:0007265; GO:0008270; GO:0018024; GO:0036124; GO:0043231; GO:0060348; GO:0090309; GO:1990841 0 0 0 PF01429;PF05033;PF00856; P06603 CHOYP_LOC100533261.1.1 m.36141 sp TBA1_DROME 96.154 130 5 0 5 134 32 161 4.70E-83 259 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P16157 CHOYP_LOC581927.15.27 m.39580 sp ANK1_HUMAN 26.95 872 490 36 600 1448 35 782 4.70E-46 186 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18433 CHOYP_PTPRE.4.19 m.25833 sp PTPRA_HUMAN 33.392 572 338 16 784 1328 238 793 4.70E-85 299 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P24643 CHOYP_LOC100304606.1.1 m.38282 sp CALX_CANLF 56.41 156 62 3 1 156 375 524 4.70E-52 179 CALX_CANLF reviewed Calnexin (pp90) CANX Canis lupus familiaris (Dog) (Canis familiaris) 593 clathrin-mediated endocytosis [GO:0072583]; protein folding [GO:0006457]; synaptic vesicle endocytosis [GO:0048488] GO:0005509; GO:0005783; GO:0005789; GO:0006457; GO:0016021; GO:0030246; GO:0042470; GO:0045202; GO:0048488; GO:0072583 0 0 0 PF00262; P38942 CHOYP_NEMVEDRAFT_V1G237598.1.1 m.11619 sp CAT2_CLOK5 43.868 424 220 6 78 498 13 421 4.70E-115 349 CAT2_CLOK5 reviewed 4-hydroxybutyrate coenzyme A transferase (EC 2.8.3.-) cat2 CKL_3018 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) 429 acetyl-CoA metabolic process [GO:0006084] GO:0006084; GO:0016740 0 0 0 PF13336;PF02550; P54145 CHOYP_NEMVEDRAFT_V1G173932.1.3 m.36366 sp AMT1_CAEEL 31.32 447 263 14 3 414 28 465 4.70E-48 175 AMT1_CAEEL reviewed Putative ammonium transporter 1 amt-1 C05E11.4 Caenorhabditis elegans 534 ammonium transmembrane transport [GO:0072488]; nitrogen utilization [GO:0019740]; organic cation transport [GO:0015695] GO:0005887; GO:0008519; GO:0015695; GO:0019740; GO:0072488 0 0 0 PF00909; Q13263 CHOYP_LOC100369754.8.10 m.60899 sp TIF1B_HUMAN 28.947 152 102 4 1 147 156 306 4.70E-09 62.8 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q14028 CHOYP_PHUM_PHUM463940.1.1 m.26522 sp CNGB1_HUMAN 49.271 343 172 1 1 343 755 1095 4.70E-115 380 CNGB1_HUMAN reviewed Cyclic nucleotide-gated cation channel beta-1 (Cyclic nucleotide-gated cation channel 4) (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel gamma) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-1) (CNG channel beta-1) (Glutamic acid-rich protein) (GARP) CNGB1 CNCG2 CNCG3L CNCG4 RCNC2 Homo sapiens (Human) 1251 cation transport [GO:0006812]; detection of light stimulus involved in visual perception [GO:0050908]; photoreceptor cell maintenance [GO:0045494]; photoreceptor cell outer segment organization [GO:0035845]; protein localization to organelle [GO:0033365]; regulation of membrane potential [GO:0042391]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; retina homeostasis [GO:0001895]; rhodopsin mediated signaling pathway [GO:0016056]; sensory perception of smell [GO:0007608]; transport [GO:0006810]; visual perception [GO:0007601] GO:0000139; GO:0001750; GO:0001895; GO:0005222; GO:0005223; GO:0005249; GO:0005886; GO:0005887; GO:0006810; GO:0006812; GO:0007601; GO:0007608; GO:0015276; GO:0016056; GO:0022400; GO:0030552; GO:0030553; GO:0030660; GO:0033365; GO:0035845; GO:0042391; GO:0045494; GO:0050908; GO:0060170; GO:1902495 0 0 0 PF00027; Q19PY9 CHOYP_LOC726755.1.1 m.1031 sp GNRHR_BOSMU 20.818 269 198 6 69 334 69 325 4.70E-11 66.6 GNRHR_BOSMU reviewed Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) GNRHR Bos mutus grunniens (Wild yak) (Bos grunniens) 328 0 GO:0004968; GO:0005886; GO:0016021 0 0 0 PF00001; Q28619 CHOYP_BRAFLDRAFT_120990.18.18 m.61786 sp NHRF1_RABIT 37.391 345 135 7 6 350 12 275 4.70E-60 202 NHRF1_RABIT reviewed Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) SLC9A3R1 NHERF NHERF1 Oryctolagus cuniculus (Rabbit) 358 bile acid secretion [GO:0032782]; glutathione transport [GO:0034635]; negative regulation of cell motility [GO:2000146]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein kinase B signaling [GO:0051898]; regulation of protein kinase activity [GO:0045859]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; Wnt signaling pathway [GO:0016055] GO:0001726; GO:0005737; GO:0005902; GO:0010642; GO:0012505; GO:0014067; GO:0016020; GO:0016055; GO:0016324; GO:0017081; GO:0030175; GO:0031528; GO:0032782; GO:0034635; GO:0045859; GO:0051898; GO:0070293; GO:0071944; GO:0097225; GO:0097291; GO:2000146 0 0 0 PF09007;PF00595; Q5R5L7 CHOYP_LOC100176335.1.7 m.14651 sp ARRD3_PONAB 33.889 360 216 9 1 348 3 352 4.70E-55 190 ARRD3_PONAB reviewed Arrestin domain-containing protein 3 ARRDC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 414 0 GO:0005764; GO:0005769; GO:0005886 0 0 0 PF02752;PF00339; Q5RB84 CHOYP_LOC100710792.1.1 m.24514 sp ZDH21_PONAB 34.848 264 169 2 42 304 4 265 4.70E-51 172 ZDH21_PONAB reviewed Probable palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 21) (DHHC-21) ZDHHC21 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 265 hair follicle development [GO:0001942]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; sebaceous gland development [GO:0048733] GO:0001942; GO:0005794; GO:0005886; GO:0008270; GO:0016021; GO:0018230; GO:0019706; GO:0048733 0 0 0 PF01529; Q6P823 CHOYP_H33.3.5 m.49594 sp H33_XENTR 100 136 0 0 55 190 1 136 4.70E-95 275 H33_XENTR reviewed Histone H3.3 TGas113e22.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q80U87 CHOYP_USP8.1.1 m.64535 sp UBP8_MOUSE 50 112 53 2 6 116 9 118 4.70E-19 92.8 UBP8_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (mUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) Usp8 Kiaa0055 Ubpy Mus musculus (Mouse) 1080 endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000281; GO:0004843; GO:0005622; GO:0005654; GO:0005737; GO:0005769; GO:0005794; GO:0005829; GO:0006511; GO:0007032; GO:0007265; GO:0016579; GO:0019897; GO:0030496; GO:0031313; GO:0070536; GO:0071108 0 0 0 PF00581;PF00443;PF08969; Q8C8H8 CHOYP_LOC100538483.1.1 m.62228 sp KY_MOUSE 28.34 494 306 18 77 560 164 619 4.70E-43 167 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8IT98 CHOYP_RS18.8.11 m.39329 sp RS18_ARGIR 86.667 90 12 0 1 90 27 116 4.70E-55 172 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8IYJ1 CHOYP_LOC100634021.1.1 m.53536 sp CPNE9_HUMAN 35.609 542 319 14 12 541 11 534 4.70E-95 304 CPNE9_HUMAN reviewed Copine-9 (Copine IX) CPNE9 Homo sapiens (Human) 553 positive regulation of dendrite extension [GO:1903861] GO:0005615; GO:0070062; GO:1903861 0 0 0 PF00168;PF07002; Q8N957 CHOYP_LOC100367672.1.1 m.58867 sp ANKF1_HUMAN 40.145 690 368 16 329 997 91 756 4.70E-157 493 ANKF1_HUMAN reviewed Ankyrin repeat and fibronectin type-III domain-containing protein 1 ANKFN1 Homo sapiens (Human) 763 0 0 0 0 0 PF00041; Q8R4G9 CHOYP_LOC100372668.2.2 m.62459 sp ACHA3_MOUSE 29.121 364 240 6 38 394 40 392 4.70E-53 187 ACHA3_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-3 Chrna3 Mus musculus (Mouse) 499 "activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; behavioral response to nicotine [GO:0035095]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of muscle contraction [GO:0006937]; regulation of smooth muscle contraction [GO:0006940]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0006937; GO:0006940; GO:0007165; GO:0007171; GO:0007271; GO:0007399; GO:0007626; GO:0014056; GO:0015464; GO:0030054; GO:0035095; GO:0042391; GO:0045211; GO:0048814; GO:0060079; GO:0060084 0 0 0 PF02931;PF02932; Q91WV7 CHOYP_BRAFLDRAFT_265208.3.7 m.10791 sp SLC31_MOUSE 31.818 660 364 23 16 641 43 650 4.70E-91 299 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q96GS4 CHOYP_LOC100862954.1.1 m.26487 sp BORC6_HUMAN 38.384 99 61 0 292 390 256 354 4.70E-20 94 BORC6_HUMAN reviewed BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin) BORCS6 C17orf59 Homo sapiens (Human) 357 lysosome localization [GO:0032418] GO:0032418; GO:0043234 0 0 0 PF10157; Q9H9A7 CHOYP_RMI1.1.1 m.17246 sp RMI1_HUMAN 49.746 197 96 1 1 194 3 199 4.70E-57 208 RMI1_HUMAN reviewed RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) RMI1 C9orf76 Homo sapiens (Human) 625 DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; glucose homeostasis [GO:0042593]; multicellular organism growth [GO:0035264]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to glucose [GO:0009749]; strand displacement [GO:0000732] GO:0000166; GO:0000731; GO:0000732; GO:0002023; GO:0005634; GO:0005654; GO:0006260; GO:0009749; GO:0035264; GO:0042593; GO:1901796 0 0 0 PF16099;PF08585; Q9U3P2 CHOYP_BRAFLDRAFT_83400.2.2 m.46031 sp SYG2_CAEEL 25.954 131 83 2 50 180 249 365 4.70E-08 58.2 SYG2_CAEEL reviewed Synaptogenesis protein syg-2 (Synaptogenesis abnormal protein 2) syg-2 C26G2.1 Caenorhabditis elegans 1270 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; collateral sprouting [GO:0048668]; protein localization to synapse [GO:0035418]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007155; GO:0007267; GO:0007416; GO:0008039; GO:0030054; GO:0035418; GO:0042803; GO:0045202; GO:0048668; GO:0050808; GO:0050839 0 0 0 PF08205;PF00041;PF07679; A4IF63 CHOYP_BRAFLDRAFT_92727.9.17 m.34059 sp TRIM2_BOVIN 26.415 159 97 6 333 490 576 715 4.71E-08 59.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5YM72 CHOYP_CARNS1.6.6 m.64237 sp CRNS1_HUMAN 58.553 152 62 1 31 181 595 746 4.71E-56 194 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 B0BNA5 CHOYP_LOC100704756.1.2 m.17112 sp COTL1_RAT 46.565 131 70 0 98 228 7 137 4.71E-35 124 COTL1_RAT reviewed Coactosin-like protein Cotl1 Clp Rattus norvegicus (Rat) 142 defense response to fungus [GO:0050832] GO:0005634; GO:0005737; GO:0005856; GO:0050832; GO:0070062 0 0 0 PF00241; G5ED84 CHOYP_KEL-8.1.1 m.32351 sp KLHL8_CAEEL 27.119 118 85 1 13 129 93 210 4.71E-06 52.8 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; P09480 CHOYP_ACH5.1.1 m.3951 sp ACHA2_CHICK 24.138 174 123 3 16 182 21 192 4.71E-09 60.1 ACHA2_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Gallus gallus (Chicken) 528 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P27701 CHOYP_DSEC_GM10209.1.1 m.49171 sp CD82_HUMAN 27.881 269 150 14 99 355 24 260 4.71E-14 74.7 CD82_HUMAN reviewed CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) CD82 KAI1 SAR2 ST6 TSPAN27 Homo sapiens (Human) 267 cell surface receptor signaling pathway [GO:0007166] GO:0005886; GO:0005887; GO:0007166; GO:0070062 0 0 0 PF00335; P62282 CHOYP_RPS11.3.5 m.30056 sp RS11_RAT 75.362 138 32 2 17 152 1 138 4.71E-73 219 RS11_RAT reviewed 40S ribosomal protein S11 Rps11 Rattus norvegicus (Rat) 158 osteoblast differentiation [GO:0001649]; translation [GO:0006412] GO:0001649; GO:0003735; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022627; GO:0044822; GO:0070062 0 0 0 PF00366;PF16205; Q0VCJ7 CHOYP_LOC100883252.1.1 m.8572 sp RERG_BOVIN 43.902 164 91 1 29 192 5 167 4.71E-44 149 RERG_BOVIN reviewed Ras-related and estrogen-regulated growth inhibitor RERG Bos taurus (Bovine) 199 negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0005829; GO:0007264; GO:0008285; GO:0009725; GO:0016020; GO:0030308 0 0 0 PF00071; Q5F359 CHOYP_BRAFLDRAFT_234234.2.2 m.50936 sp TPPC5_CHICK 60.843 166 65 0 122 287 6 171 4.71E-76 233 TPPC5_CHICK reviewed Trafficking protein particle complex subunit 5 TRAPPC5 RCJMB04_33f11 Gallus gallus (Chicken) 188 vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005794; GO:0016192 0 0 cd14943; PF04051; Q60HC2 CHOYP_LOC100366486.1.1 m.15012 sp TBB3_MACFA 85.714 105 12 1 12 113 346 450 4.71E-57 186 TBB3_MACFA reviewed Tubulin beta-3 chain (Tubulin beta-4 chain) TUBB3 TUBB4 QccE-11995 QccE-15186 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 450 axon guidance [GO:0007411]; microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0007411 0 0 0 PF00091;PF03953; Q61187 CHOYP_TS101.3.4 m.49580 sp TS101_MOUSE 50.282 177 68 2 1 177 1 157 4.71E-56 187 TS101_MOUSE reviewed Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Tsg101 Mus musculus (Mouse) 391 "cell cycle arrest [GO:0007050]; cell differentiation [GO:0030154]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; keratinocyte differentiation [GO:0030216]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein monoubiquitination [GO:0006513]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]" GO:0000813; GO:0001558; GO:0003714; GO:0005634; GO:0005730; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0006513; GO:0007050; GO:0008285; GO:0008333; GO:0015031; GO:0030154; GO:0030216; GO:0030374; GO:0031625; GO:0031902; GO:0042803; GO:0043130; GO:0043162; GO:0043405; GO:0045892; GO:0046755; GO:0046790; GO:0048306; GO:0048524; GO:0051301; GO:0070062; GO:1902188; GO:1903543; GO:1903551; GO:1903772; GO:1903774; GO:1990182; GO:2000397 0 0 0 PF05743;PF09454; Q6AX44 CHOYP_LOC101067075.1.2 m.30552 sp FBCDA_XENLA 51.807 166 66 4 46 198 282 446 4.71E-46 160 FBCDA_XENLA reviewed Fibrinogen C domain-containing protein 1-A fibcd1-a Xenopus laevis (African clawed frog) 457 0 GO:0008061; GO:0016021; GO:0046872 0 0 0 PF00147; Q6DRC3 CHOYP_CYTB.1.6 m.7874 sp CU059_DANRE 64.138 290 104 0 1 290 1 290 4.71E-144 409 CU059_DANRE reviewed UPF0769 protein C21orf59 homolog 0 Danio rerio (Zebrafish) (Brachydanio rerio) 290 cilium morphogenesis [GO:0060271] GO:0005737; GO:0060271 0 0 0 PF11069; Q6NZQ8 CHOYP_MARCH8.1.1 m.33775 sp MARH1_MOUSE 55.603 232 96 2 8 235 15 243 4.71E-89 269 MARH1_MOUSE reviewed E3 ubiquitin-protein ligase MARCH1 (EC 6.3.2.-) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) 1-Mar Mus musculus (Mouse) 289 antigen processing and presentation of peptide antigen via MHC class II [GO:0002495]; immune response [GO:0006955]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0002495; GO:0004842; GO:0005764; GO:0005765; GO:0005768; GO:0005789; GO:0005886; GO:0006955; GO:0008270; GO:0016021; GO:0016874; GO:0030659; GO:0031901; GO:0031902; GO:0032588; GO:0042287; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q6P9P0 CHOYP_BRAFLDRAFT_124025.1.1 m.16637 sp SLF2_MOUSE 24.464 560 366 15 741 1253 707 1256 4.71E-31 136 SLF2_MOUSE reviewed SMC5-SMC6 complex localization factor protein 2 Slf2 Fam178a Mus musculus (Mouse) 1278 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166] GO:0000785; GO:0005615; GO:0005634; GO:0006281; GO:0006974; GO:0031334; GO:0031625; GO:0032403; GO:0034184; GO:0035861; GO:0043231; GO:1990166; GO:2000781 0 0 0 PF14816; Q6XUX1 CHOYP_BRAFLDRAFT_81321.10.10 m.66491 sp DUSTY_MOUSE 25.867 375 214 15 541 902 519 842 4.71E-19 96.7 DUSTY_MOUSE reviewed Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) Dstyk Ripk5 Mus musculus (Mouse) 927 cellular response to fibroblast growth factor stimulus [GO:0044344]; intracellular signal transduction [GO:0035556]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; positive regulation of kinase activity [GO:0033674]; protein phosphorylation [GO:0006468] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0016323; GO:0016324; GO:0030054; GO:0033674; GO:0035556; GO:0044344; GO:0045743; GO:0070374 0 0 0 PF07714; Q71RH2 CHOYP_FA57B.3.3 m.50066 sp FA57B_HUMAN 39.147 258 144 3 8 254 6 261 4.71E-55 181 FA57B_HUMAN reviewed Protein FAM57B FAM57B FP1188 Homo sapiens (Human) 274 ceramide biosynthetic process [GO:0046513]; negative regulation of fat cell differentiation [GO:0045599] GO:0000139; GO:0005783; GO:0005789; GO:0016021; GO:0045599; GO:0046513; GO:0050291 0 0 0 PF03798; Q8IV33 CHOYP_LOC100890552.1.2 m.31526 sp K0825_HUMAN 25.271 277 191 7 31 299 92 360 4.71E-12 71.2 K0825_HUMAN reviewed Uncharacterized protein KIAA0825 KIAA0825 C5orf36 Homo sapiens (Human) 1275 0 0 0 0 0 PF14906; Q99NH0 CHOYP_LOC581927.10.27 m.32671 sp ANR17_MOUSE 30.398 352 200 15 12 348 299 620 4.71E-26 113 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9H2G2 CHOYP_ISCW_ISCW014720.2.2 m.2338 sp SLK_HUMAN 40.183 219 131 0 55 273 827 1045 4.71E-35 136 SLK_HUMAN reviewed STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) SLK KIAA0204 STK2 Homo sapiens (Human) 1235 apoptotic process [GO:0006915]; cytoplasmic microtubule organization [GO:0031122]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; regulation of cell migration [GO:0030334]; regulation of focal adhesion assembly [GO:0051893] GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005913; GO:0006915; GO:0030334; GO:0031122; GO:0031252; GO:0042802; GO:0042803; GO:0042981; GO:0046777; GO:0048471; GO:0051893; GO:0070062; GO:0098641 0 0 0 PF00069;PF12474; Q9PWL6 CHOYP_AGAP_AGAP004664.1.1 m.30826 sp HXA9A_DANRE 41.538 130 50 5 63 191 142 246 4.71E-21 90.9 HXA9A_DANRE reviewed Homeobox protein Hox-A9a (Hoxx9) hoxa9a hoxx9 zgc:110505 Danio rerio (Zebrafish) (Brachydanio rerio) 250 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046;PF04617; Q9VCY8 CHOYP_INF2.3.5 m.13729 sp ADRL_DROME 65.823 316 108 0 79 394 120 435 4.71E-153 442 ADRL_DROME reviewed Adiponectin receptor protein AdipoR CG5315 Drosophila melanogaster (Fruit fly) 444 adiponectin-activated signaling pathway [GO:0033211]; fatty acid oxidation [GO:0019395]; female germ-line stem cell population maintenance [GO:0036099]; glucose homeostasis [GO:0042593]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of insulin secretion [GO:0032024]; triglyceride homeostasis [GO:0070328] GO:0005886; GO:0009755; GO:0016021; GO:0019395; GO:0032024; GO:0033211; GO:0036099; GO:0042562; GO:0042593; GO:0046872; GO:0070328; GO:0097003 0 0 0 PF03006; A2A8L5 CHOYP_PTPRF.1.6 m.16667 sp PTPRF_MOUSE 22.664 578 343 23 282 816 426 942 4.72E-13 77.8 PTPRF_MOUSE reviewed Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) Ptprf Lar Mus musculus (Mouse) 1898 cell adhesion [GO:0007155]; cell migration [GO:0016477]; negative regulation of receptor binding [GO:1900121]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; regulation of neuron projection development [GO:0010975] GO:0004721; GO:0004725; GO:0007155; GO:0008201; GO:0010975; GO:0016021; GO:0016477; GO:0031102; GO:0032403; GO:0035335; GO:0035373; GO:0043005; GO:0043025; GO:0048679; GO:0070062; GO:1900121 0 0 0 PF00041;PF07679;PF00102; P27080 CHOYP_LOC100633390.4.5 m.46303 sp ADT_CHLRE 66.787 277 90 2 1 275 1 277 4.72E-129 373 ADT_CHLRE reviewed "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" ABT Chlamydomonas reinhardtii (Chlamydomonas smithii) 308 transmembrane transport [GO:0055085] GO:0005215; GO:0005743; GO:0016021; GO:0055085 0 0 0 PF00153; P40305 CHOYP_ACA1_226540.2.2 m.14054 sp IFI27_HUMAN 51.579 95 34 2 169 263 35 117 4.72E-16 76.3 IFI27_HUMAN reviewed "Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a))" IFI27 Homo sapiens (Human) 119 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of protein export from nucleus [GO:0046825]; type I interferon signaling pathway [GO:0060337] GO:0000122; GO:0001102; GO:0005521; GO:0005637; GO:0005739; GO:0005741; GO:0006919; GO:0016021; GO:0046825; GO:0060337; GO:0097190 0 0 0 PF06140; P42577 CHOYP_LOC100533455.4.9 m.24717 sp FRIS_LYMST 82.609 138 24 0 68 205 23 160 4.72E-82 244 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P49109 CHOYP_BRAFLDRAFT_113828.2.2 m.38816 sp FMO5_CAVPO 50 146 73 0 1 146 372 517 4.72E-41 146 FMO5_CAVPO reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Cavia porcellus (Guinea pig) 533 0 GO:0004499; GO:0005789; GO:0016021; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; P62264 CHOYP_RS14.6.6 m.63535 sp RS14_MOUSE 89.286 140 14 1 17 155 1 140 4.72E-89 259 RS14_MOUSE reviewed 40S ribosomal protein S14 Rps14 Mus musculus (Mouse) 151 "erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]" GO:0000028; GO:0000122; GO:0000462; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005739; GO:0005925; GO:0006412; GO:0016020; GO:0022627; GO:0030218; GO:0030490; GO:0044822; GO:0045182; GO:0048027; GO:0070062; GO:0070181 0 0 0 PF00411; Q02357 CHOYP_LOC578679.6.6 m.53428 sp ANK1_MOUSE 29.855 690 418 10 580 1236 111 767 4.72E-71 267 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q3SZQ6 CHOYP_ISCW_ISCW012366.1.1 m.3694 sp RL32_BOVIN 78.431 51 10 1 22 71 3 53 4.72E-20 81.3 RL32_BOVIN reviewed 60S ribosomal protein L32 RPL32 Bos taurus (Bovine) 135 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 cd00513; PF01655; Q4UMH6 CHOYP_AAEL_AAEL014668.1.2 m.22905 sp Y381_RICFE 26.797 306 194 9 2 304 741 1019 4.72E-14 76.6 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5M981 CHOYP_LOC100371864.1.1 m.51199 sp UB12B_XENLA 36.634 101 61 2 140 239 40 138 4.72E-09 60.1 UB12B_XENLA reviewed Ubiquitin carboxyl-terminal hydrolase 12-B (EC 3.4.19.12) (Deubiquitinating enzyme 12-B) (Ubiquitin thioesterase 12-B) (Ubiquitin-specific-processing protease 12-B) usp12-b Xenopus laevis (African clawed frog) 370 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004197; GO:0004843; GO:0006511; GO:0016579 0 0 0 PF00443; Q7KIN0 CHOYP_PHUM_PHUM081740.1.1 m.2188 sp TOLL7_DROME 24.851 1171 699 38 127 1177 125 1234 4.72E-54 211 TOLL7_DROME reviewed Toll-like receptor 7 Toll-7 CG8595 Drosophila melanogaster (Fruit fly) 1446 axon guidance [GO:0007411]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of autophagy [GO:0010508]; regulation of defense response to virus [GO:0050688] GO:0002752; GO:0005030; GO:0005887; GO:0007411; GO:0008329; GO:0009897; GO:0010508; GO:0045087; GO:0046790; GO:0050688; GO:0051607 0 0 0 PF13855;PF01582; Q9ESN6 CHOYP_BRAFLDRAFT_93221.1.1 m.47062 sp TRIM2_MOUSE 29.592 196 122 9 78 266 535 721 4.72E-10 63.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9VCA8 CHOYP_LOC764549.2.3 m.40990 sp ANKHM_DROME 33.574 277 169 8 1 265 625 898 4.72E-33 130 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; A0JM12 CHOYP_MEGF6.24.59 m.34456 sp MEG10_XENTR 36.31 336 183 15 192 514 94 411 4.73E-38 154 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2AX52 CHOYP_LOC100486063.2.9 m.5918 sp CO6A4_MOUSE 27.938 1217 763 40 22 1163 27 1204 4.73E-114 397 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; D2GXS7 CHOYP_BRAFLDRAFT_69647.4.5 m.47293 sp TRIM2_AILME 25 256 176 8 119 361 492 744 4.73E-11 67.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3Z3C6 CHOYP_LOC100051390.1.1 m.57617 sp ZFAN4_MOUSE 58.555 263 93 6 1 252 54 311 4.73E-85 284 ZFAN4_MOUSE reviewed AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1) Zfand4 Anubl1 Mus musculus (Mouse) 739 0 GO:0008270 0 0 0 PF00240;PF01428; O54890 CHOYP_ITB1.1.4 m.13048 sp ITB3_MOUSE 33.333 483 284 17 1 469 323 781 4.73E-79 265 ITB3_MOUSE reviewed Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) Itgb3 Mus musculus (Mouse) 787 activation of protein kinase activity [GO:0032147]; angiogenesis involved in wound healing [GO:0060055]; apolipoprotein A-I-mediated signaling pathway [GO:0038027]; cell adhesion mediated by integrin [GO:0033627]; cell growth [GO:0016049]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell projection morphogenesis [GO:0048858]; cell-substrate adhesion [GO:0031589]; cell-substrate junction assembly [GO:0007044]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; heterotypic cell-cell adhesion [GO:0034113]; integrin-mediated signaling pathway [GO:0007229]; negative chemotaxis [GO:0050919]; negative regulation of lipid storage [GO:0010888]; negative regulation of lipid transport [GO:0032369]; negative regulation of lipoprotein metabolic process [GO:0050748]; negative regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045715]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of bone resorption [GO:0045780]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of T cell migration [GO:2000406]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of extracellular matrix organization [GO:1903053]; regulation of protein tyrosine kinase activity [GO:0061097]; smooth muscle cell migration [GO:0014909]; substrate adhesion-dependent cell spreading [GO:0034446]; viral entry into host cell [GO:0046718] GO:0001938; GO:0001954; GO:0001968; GO:0002020; GO:0003756; GO:0004872; GO:0005178; GO:0005634; GO:0005886; GO:0005925; GO:0007044; GO:0007160; GO:0007229; GO:0008305; GO:0009897; GO:0009986; GO:0010595; GO:0010628; GO:0010745; GO:0010763; GO:0010888; GO:0014909; GO:0016049; GO:0016324; GO:0016477; GO:0019899; GO:0030168; GO:0030334; GO:0030335; GO:0031258; GO:0031527; GO:0031528; GO:0031589; GO:0032147; GO:0032369; GO:0032587; GO:0032956; GO:0033627; GO:0033690; GO:0034113; GO:0034446; GO:0034679; GO:0034683; GO:0035867; GO:0036120; GO:0038027; GO:0042470; GO:0042802; GO:0043184; GO:0043235; GO:0045672; GO:0045715; GO:0045780; GO:0046718; GO:0048008; GO:0048146; GO:0048858; GO:0050731; GO:0050748; GO:0050839; GO:0050840; GO:0050919; GO:0060055; GO:0061097; GO:0070062; GO:0070527; GO:0071133; GO:1900026; GO:1903053; GO:2000406 0 0 0 PF07974;PF08725;PF07965;PF00362; P07607 CHOYP_LOC100013725.2.2 m.42228 sp TYSY_MOUSE 72.973 296 80 0 70 365 12 307 4.73E-165 466 TYSY_MOUSE reviewed Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) Tyms Mus musculus (Mouse) 307 aging [GO:0007568]; cartilage development [GO:0051216]; circadian rhythm [GO:0007623]; developmental growth [GO:0048589]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; dUMP metabolic process [GO:0046078]; immortalization of host cell by virus [GO:0019088]; intestinal epithelial cell maturation [GO:0060574]; organ regeneration [GO:0031100]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; response to organophosphorus [GO:0046683]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; tetrahydrofolate interconversion [GO:0035999]; uracil metabolic process [GO:0019860] GO:0000166; GO:0003729; GO:0004799; GO:0005542; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006231; GO:0006235; GO:0007568; GO:0007623; GO:0008144; GO:0009636; GO:0019088; GO:0019860; GO:0031100; GO:0032570; GO:0033189; GO:0034097; GO:0035999; GO:0042493; GO:0045471; GO:0046078; GO:0046683; GO:0048037; GO:0048589; GO:0051216; GO:0051384; GO:0051593; GO:0060574 PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. 0 0 PF00303; P43143 CHOYP_ACHA.1.2 m.26366 sp ACHA6_RAT 31.535 241 150 8 1 231 94 329 4.73E-31 125 ACHA6_RAT reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Acra6 Rattus norvegicus (Rat) 493 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of dopamine secretion [GO:0033603]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0016020; GO:0030054; GO:0033603; GO:0035094; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; Q00725 CHOYP_contig_017759 m.20790 sp SGS4_DROME 52.83 106 50 0 6 111 70 175 4.73E-11 60.8 SGS4_DROME reviewed Salivary glue protein Sgs-4 Sgs4 Sgs-4 CG12181 Drosophila melanogaster (Fruit fly) 297 0 GO:0005576 0 0 0 0 Q149M9 CHOYP_LOC100378314.1.3 m.16428 sp NWD1_HUMAN 38.989 277 158 6 52 321 447 719 4.73E-48 176 NWD1_HUMAN reviewed NACHT domain- and WD repeat-containing protein 1 NWD1 Homo sapiens (Human) 1564 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; Q31125 CHOYP_NEMVEDRAFT_V1G241132.1.1 m.9834 sp S39A7_MOUSE 46.087 460 159 12 129 550 68 476 4.73E-102 319 S39A7_MOUSE reviewed "Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)" Slc39a7 H2-Ke4 Hke4 Mus musculus (Mouse) 476 cellular zinc ion homeostasis [GO:0006882]; zinc II ion transmembrane transport [GO:0071577] GO:0005385; GO:0005654; GO:0005783; GO:0005789; GO:0005794; GO:0006882; GO:0016021; GO:0071577 0 0 0 PF02535; Q3B8D7 CHOYP_BRAFLDRAFT_126379.3.3 m.12266 sp TC1DA_XENLA 40.945 127 71 2 104 229 54 177 4.73E-26 102 TC1DA_XENLA reviewed Tctex1 domain-containing protein 1-A tctex1d1-a Xenopus laevis (African clawed frog) 177 0 0 0 0 0 PF03645; Q5RER2 CHOYP_ATRAP.1.2 m.8198 sp ATRAP_PONAB 33.945 109 51 3 2 109 49 137 4.73E-09 54.3 ATRAP_PONAB reviewed Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein) AGTRAP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 152 angiotensin-activated signaling pathway [GO:0038166] GO:0000139; GO:0005789; GO:0016021; GO:0030659; GO:0038166 0 0 0 PF06396; Q5RFQ0 CHOYP_LOC100177727.1.1 m.12159 sp FCF1_PONAB 72.081 197 54 1 109 305 2 197 4.73E-102 300 FCF1_PONAB reviewed rRNA-processing protein FCF1 homolog FCF1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 198 rRNA processing [GO:0006364] GO:0005730; GO:0006364; GO:0032040 0 0 0 PF04900; Q67XX3 CHOYP_LOC100369871.1.2 m.32314 sp FB252_ARATH 24.49 245 131 8 141 349 193 419 4.73E-09 61.2 FB252_ARATH reviewed F-box protein At5g06550 At5g06550 F15M7.8 Arabidopsis thaliana (Mouse-ear cress) 502 histone H4-R3 methylation [GO:0043985]; positive regulation of seed germination [GO:0010030] GO:0000987; GO:0005634; GO:0010030; GO:0043985 0 0 0 0 Q7LHG5 CHOYP_contig_006832 m.7794 sp YI31B_YEAST 31.76 932 555 23 333 1253 615 1476 4.73E-119 410 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q7TN88 CHOYP_LOC100378512.4.6 m.44004 sp PK1L2_MOUSE 30.38 395 257 7 23 413 1276 1656 4.73E-57 206 PK1L2_MOUSE reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) 2461 detection of mechanical stimulus [GO:0050982] GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q80X19 CHOYP_COCA1.1.6 m.28520 sp COEA1_MOUSE 36.17 188 112 4 17 203 1027 1207 4.73E-28 118 COEA1_MOUSE reviewed Collagen alpha-1(XIV) chain Col14a1 Mus musculus (Mouse) 1797 cell adhesion [GO:0007155]; collagen fibril organization [GO:0030199]; homeostasis of number of cells within a tissue [GO:0048873]; regulation of cell growth involved in cardiac muscle cell development [GO:0061050]; ventricular cardiac muscle tissue development [GO:0003229] GO:0003229; GO:0005581; GO:0005614; GO:0005615; GO:0007155; GO:0030199; GO:0044822; GO:0048873; GO:0061050; GO:0070062 0 0 0 PF01391;PF00041;PF00092; Q86WZ0 CHOYP_LOC100369763.1.1 m.45387 sp HEAT4_HUMAN 29.443 951 529 20 48 965 48 889 4.73E-111 377 HEAT4_HUMAN reviewed HEAT repeat-containing protein 4 HEATR4 Homo sapiens (Human) 1026 0 0 0 0 0 PF02985; Q91VR8 CHOYP_BRK1.1.3 m.12345 sp BRK1_MOUSE 76.056 71 17 0 23 93 3 73 4.73E-32 110 BRK1_MOUSE reviewed Protein BRICK1 (BRK1) Brk1 Mus musculus (Mouse) 75 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell motility [GO:0048870]; in utero embryonic development [GO:0001701]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of cell proliferation [GO:0008284]; positive regulation of lamellipodium assembly [GO:0010592]; protein homotrimerization [GO:0070207]; Rac protein signal transduction [GO:0016601] GO:0001701; GO:0005856; GO:0007015; GO:0008284; GO:0010592; GO:0016601; GO:0030027; GO:0030036; GO:0031209; GO:0032403; GO:0048870; GO:0070062; GO:0070207; GO:2000601 0 0 0 0 Q96M86 CHOYP_LOC100376274.3.7 m.21301 sp DNHD1_HUMAN 22.511 924 612 20 145 1014 660 1533 4.73E-47 188 DNHD1_HUMAN reviewed Dynein heavy chain domain-containing protein 1 (Dynein heavy chain domain 1-like protein) (Protein CCDC35) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) 4753 microtubule-based movement [GO:0007018] GO:0003777; GO:0007018; GO:0030286; GO:0070062 0 0 0 PF08393;PF03028;PF12777; Q9BQA9 CHOYP_LOC101369831.1.1 m.54810 sp CQ062_HUMAN 39.227 181 107 2 4 182 3 182 4.73E-38 132 CQ062_HUMAN reviewed Uncharacterized protein C17orf62 C17orf62 Homo sapiens (Human) 187 0 GO:0016021 0 0 0 PF15169; Q9BXK5 CHOYP_BCL2L13.1.1 m.45301 sp B2L13_HUMAN 29.379 177 115 5 346 520 42 210 4.73E-15 81.6 B2L13_HUMAN reviewed Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1) BCL2L13 MIL1 CD003 Homo sapiens (Human) 485 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915] GO:0005634; GO:0005739; GO:0006915; GO:0006919; GO:0008656; GO:0016021; GO:0031966 0 0 0 PF00452; Q9D099 CHOYP_ACER3.1.1 m.6185 sp ACER3_MOUSE 44.697 264 143 2 2 262 3 266 4.73E-69 217 ACER3_MOUSE reviewed Alkaline ceramidase 3 (AlkCDase 3) (Alkaline CDase 3) (EC 3.5.1.-) (Alkaline phytoceramidase) (aPHC) Acer3 Aphc Phca Mus musculus (Mouse) 267 ceramide metabolic process [GO:0006672]; phytosphingosine biosynthetic process [GO:0071602]; positive regulation of cell proliferation [GO:0008284]; sphingosine biosynthetic process [GO:0046512] GO:0006672; GO:0008284; GO:0030173; GO:0030176; GO:0046512; GO:0070774; GO:0071602 0 0 0 PF05875; Q9ESN6 CHOYP_TRIM2.19.59 m.32488 sp TRIM2_MOUSE 29.891 184 112 9 74 250 534 707 4.73E-08 57 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9MYM7 CHOYP_LOC100121044.1.1 m.57738 sp B3GT1_PONPY 28.689 244 166 5 128 367 80 319 4.73E-34 132 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9UMY4 CHOYP_CPIPJ_CPIJ001623.1.1 m.19531 sp SNX12_HUMAN 71.429 161 44 1 13 173 1 159 4.73E-82 243 SNX12_HUMAN reviewed Sorting nexin-12 SNX12 Homo sapiens (Human) 172 negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; vesicle organization [GO:0016050] GO:0005769; GO:0010629; GO:0010955; GO:0015031; GO:0016050; GO:0019898; GO:0019899; GO:0030100; GO:0035091; GO:0042177; GO:0051224; GO:0070062; GO:2000642 0 0 0 PF00787; Q9Y2E6 CHOYP_DTX4.1.1 m.6324 sp DTX4_HUMAN 62.443 221 80 2 558 776 392 611 4.73E-88 293 DTX4_HUMAN reviewed E3 ubiquitin-protein ligase DTX4 (EC 6.3.2.-) (Protein deltex-4) (Deltex4) (RING finger protein 155) DTX4 KIAA0937 RNF155 Homo sapiens (Human) 619 Notch signaling pathway [GO:0007219]; regulation of type I interferon production [GO:0032479] GO:0004842; GO:0005829; GO:0007219; GO:0008270; GO:0016874; GO:0032479 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02825;PF00097; D3YXG0 CHOYP_UNC89.8.19 m.35375 sp HMCN1_MOUSE 24.282 383 240 11 138 498 945 1299 4.74E-08 62 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; E9Q555 CHOYP_BRAFLDRAFT_108418.2.2 m.47716 sp RN213_MOUSE 35.878 131 72 4 2 127 1806 1929 4.74E-17 79.3 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O08856 CHOYP_ELL.1.1 m.21542 sp ELL_MOUSE 52.941 119 55 1 356 473 479 597 4.74E-32 132 ELL_MOUSE reviewed RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein) Ell Mus musculus (Mouse) 602 in utero embryonic development [GO:0001701]; negative regulation of phosphatase activity [GO:0010923]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase III promoter [GO:0045945]; snRNA transcription from RNA polymerase III promoter [GO:0042796]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; transcription elongation from RNA polymerase II promoter [GO:0006368] GO:0001701; GO:0005634; GO:0005737; GO:0005886; GO:0006368; GO:0008023; GO:0010923; GO:0015030; GO:0015629; GO:0016607; GO:0019902; GO:0032968; GO:0035327; GO:0035363; GO:0042795; GO:0042796; GO:0045945 0 0 0 PF10390;PF07303; O42127 CHOYP_BRAFLDRAFT_99630.7.9 m.41438 sp FGFR3_XENLA 31.429 420 250 13 877 1263 329 743 4.74E-45 179 FGFR3_XENLA reviewed Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) fgfr3 Xenopus laevis (African clawed frog) 802 apoptotic process [GO:0006915]; positive regulation of cell proliferation [GO:0008284]; skeletal system development [GO:0001501] GO:0001501; GO:0005007; GO:0005524; GO:0005886; GO:0006915; GO:0008284; GO:0016021 0 0 0 PF07679;PF07714; O43399 CHOYP_LOC100878467.4.4 m.26007 sp TPD54_HUMAN 39.506 162 85 2 111 272 55 203 4.74E-31 117 TPD54_HUMAN reviewed Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) 206 regulation of cell proliferation [GO:0042127] GO:0005737; GO:0042127; GO:0042803; GO:0044822; GO:0046982; GO:0048471 0 0 0 PF04201; O95758 CHOYP_LOC100871266.1.1 m.38964 sp PTBP3_HUMAN 48.394 436 181 10 5 419 29 441 4.74E-123 371 PTBP3_HUMAN reviewed Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1) PTBP3 ROD1 Homo sapiens (Human) 552 anatomical structure morphogenesis [GO:0009653]; erythrocyte maturation [GO:0043249]; mRNA processing [GO:0006397]; negative regulation of RNA splicing [GO:0033119]; regulation of cell differentiation [GO:0045595]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005634; GO:0006397; GO:0008380; GO:0009653; GO:0033119; GO:0043249; GO:0044822; GO:0045595 0 0 0 PF00076; P09593 CHOYP_LOC100497129.5.8 m.38523 sp SANT_PLAFV 38.418 177 104 1 102 278 110 281 4.74E-06 52.8 SANT_PLAFV reviewed S-antigen protein 0 Plasmodium falciparum (isolate v1) 375 0 GO:0020003 0 0 0 PF05756; P16157 CHOYP_LOC583072.4.25 m.20255 sp ANK1_HUMAN 28.409 704 418 27 148 789 82 761 4.74E-39 160 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20478 CHOYP_GLNA2.3.4 m.38422 sp GLNA2_DROME 75.417 240 59 0 2 241 84 323 4.74E-143 408 GLNA2_DROME reviewed Glutamine synthetase 2 cytoplasmic (EC 6.3.1.2) (Glutamate--ammonia ligase 2) Gs2 CG1743 Drosophila melanogaster (Fruit fly) 369 glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; neurotransmitter receptor metabolic process [GO:0045213]; synapse assembly [GO:0007416] GO:0004356; GO:0005524; GO:0005737; GO:0006538; GO:0006542; GO:0007416; GO:0045213 0 0 0 PF00120;PF03951; P35604 CHOYP_LOC100115298.1.1 m.39207 sp COPZ1_BOVIN 66.102 177 60 0 20 196 1 177 4.74E-88 259 COPZ1_BOVIN reviewed Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) COPZ1 COPZ Bos taurus (Bovine) 177 "intracellular protein transport [GO:0006886]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; toxin transport [GO:1901998]" GO:0000139; GO:0006886; GO:0006890; GO:0006891; GO:0030126; GO:1901998 0 0 0 PF01217; P42674 CHOYP_LOC581452.3.4 m.41000 sp BP10_PARLI 35.816 282 155 9 65 337 60 324 4.74E-39 157 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; Q03650 CHOYP_LOC100535301.5.5 m.53275 sp CRAM_TRYBB 26.935 323 199 21 2 309 534 834 4.74E-22 100 CRAM_TRYBB reviewed "Cysteine-rich, acidic integral membrane protein" CRAM Trypanosoma brucei brucei 945 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021; GO:0020016 0 0 0 PF07016; Q15935 CHOYP_ZN699.1.1 m.12723 sp ZNF77_HUMAN 39.048 210 121 4 203 406 246 454 4.74E-39 150 ZNF77_HUMAN reviewed Zinc finger protein 77 (ZNFpT1) ZNF77 Homo sapiens (Human) 545 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q25010 CHOYP_NEMVEDRAFT_V1G169611.1.1 m.25715 sp ACT3A_HELAM 63.636 176 23 4 1 174 228 364 4.74E-59 191 ACT3A_HELAM reviewed "Actin, cytoplasmic A3a" actA3a Helicoverpa armigera (Cotton bollworm) (Heliothis armigera) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q4R7T5 CHOYP_NEMVEDRAFT_V1G122840.2.2 m.30686 sp CDKL2_MACFA 58.968 407 151 6 1 392 1 406 4.74E-172 505 CDKL2_MACFA reviewed Cyclin-dependent kinase-like 2 (EC 2.7.11.22) CDKL2 QtsA-14426 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 570 0 GO:0004693; GO:0005524; GO:0005634; GO:0005737 0 0 0 PF00069; Q502M6 CHOYP_TVAG_123950.11.31 m.32952 sp ANR29_DANRE 40.299 134 80 0 1 134 67 200 4.74E-27 104 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q6P1C6 CHOYP_LOC101070753.1.1 m.688 sp LRIG3_MOUSE 23.988 321 200 14 27 342 490 771 4.74E-13 75.5 LRIG3_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) Lrig3 Kiaa3016 Mus musculus (Mouse) 1117 otolith morphogenesis [GO:0032474] GO:0005615; GO:0005886; GO:0016021; GO:0030659; GO:0032474 0 0 0 PF07679;PF13855; Q6TLE4 CHOYP_LOC100891486.1.2 m.57216 sp MMGT1_DANRE 49.524 105 52 1 17 121 5 108 4.74E-27 100 MMGT1_DANRE reviewed Membrane magnesium transporter 1 (ER membrane protein complex subunit 5) (Transmembrane protein 32) mmgt1 emc5 tmem32 zgc:92918 Danio rerio (Zebrafish) (Brachydanio rerio) 130 cation transmembrane transport [GO:0098655]; magnesium ion transport [GO:0015693] GO:0000139; GO:0005769; GO:0005794; GO:0005886; GO:0015095; GO:0015693; GO:0016021; GO:0022890; GO:0031901; GO:0072546; GO:0098655 0 0 0 PF10270; Q8BQ89 CHOYP_LIX1L.1.1 m.59787 sp LIX1L_MOUSE 78.824 255 54 0 69 323 76 330 4.74E-152 433 LIX1L_MOUSE reviewed LIX1-like protein Lix1l Mus musculus (Mouse) 337 autophagosome maturation [GO:0097352] GO:0005737; GO:0097352 0 0 0 PF14954; Q8IXQ4 CHOYP_LOC100145215.1.1 m.6903 sp GPAM1_HUMAN 35.433 381 188 12 5 371 4 340 4.74E-54 184 GPAM1_HUMAN reviewed GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) GPALPP1 KIAA1704 LSR7 AD029 Homo sapiens (Human) 340 0 0 0 0 0 PF12572; Q8TBH0 CHOYP_LOC100158379.1.1 m.29144 sp ARRD2_HUMAN 28.667 300 190 11 16 305 23 308 4.74E-31 125 ARRD2_HUMAN reviewed Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) 407 signal transduction [GO:0007165] GO:0005886; GO:0007165; GO:0031410 0 0 0 PF02752;PF00339; Q967R6 CHOYP_CPEB.1.2 m.19045 sp CPEB_APLCA 64.626 294 88 1 31 324 347 624 4.74E-129 389 CPEB_APLCA reviewed Cytoplasmic polyadenylation element-binding protein (CPE-binding protein) (CPEB) 0 Aplysia californica (California sea hare) 687 positive regulation of translation [GO:0045727]; regulation of protein localization [GO:0032880]; regulation of synaptic plasticity [GO:0048167] GO:0000166; GO:0003729; GO:0008494; GO:0032880; GO:0043005; GO:0045727; GO:0048167; GO:0071598 0 0 0 PF16368;PF16366;PF16367; Q9GLW9 CHOYP_LOC101075536.1.1 m.42991 sp PRDX5_PAPHA 45.098 153 81 2 41 191 57 208 4.74E-46 154 PRDX5_PAPHA reviewed "Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Peroxiredoxin V) (Prx-V) (Thioredoxin reductase)" PRDX5 Papio hamadryas (Hamadryas baboon) 215 cell redox homeostasis [GO:0045454] GO:0004601; GO:0005739; GO:0005777; GO:0045454; GO:0051920 0 0 0 PF08534; Q9VRV7 CHOYP_LOC100181343.1.1 m.59214 sp SF3B6_DROME 76.471 119 28 0 15 133 1 119 4.74E-67 201 SF3B6_DROME reviewed Splicing factor 3B subunit 6-like protein (Pre-mRNA branch site p14-like protein) CG13298 Drosophila melanogaster (Fruit fly) 121 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]; neurogenesis [GO:0022008]; neuron projection morphogenesis [GO:0048812]" GO:0000166; GO:0000398; GO:0003729; GO:0005684; GO:0005689; GO:0007052; GO:0022008; GO:0048812; GO:0071011; GO:0071013 0 0 0 PF00076; Q9WTK8 CHOYP_SPO11.1.1 m.46737 sp SPO11_MOUSE 50.72 347 171 0 13 359 47 393 4.74E-129 378 SPO11_MOUSE reviewed Meiotic recombination protein SPO11 (EC 5.99.1.3) Spo11 Mus musculus (Mouse) 396 "DNA catabolic process, endonucleolytic [GO:0000737]; male meiosis I [GO:0007141]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; synapsis [GO:0007129]; synaptonemal complex assembly [GO:0007130]" GO:0000737; GO:0000781; GO:0001541; GO:0003677; GO:0003918; GO:0005524; GO:0005654; GO:0007129; GO:0007130; GO:0007131; GO:0007141; GO:0007286; GO:0016888; GO:0034502; GO:0045141; GO:0046872; GO:0048477 0 0 0 PF03533;PF04406; E7FAM5 CHOYP_BRAFLDRAFT_88218.7.8 m.63818 sp LIN41_DANRE 21.026 585 342 25 12 535 151 676 4.75E-09 62.8 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O43301 CHOYP_BRAFLDRAFT_208436.17.32 m.54925 sp HS12A_HUMAN 31.461 534 301 12 1 482 61 581 4.75E-77 258 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P04157 CHOYP_PTPRC.10.14 m.46482 sp PTPRC_RAT 39.527 296 154 9 11 298 659 937 4.75E-50 181 PTPRC_RAT reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) Ptprc Rattus norvegicus (Rat) 1273 B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of T cell proliferation [GO:0042102]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; release of sequestered calcium ion into cytosol [GO:0051209]; response to gamma radiation [GO:0010332]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] GO:0001915; GO:0001960; GO:0004725; GO:0005001; GO:0005887; GO:0005925; GO:0006469; GO:0006470; GO:0009898; GO:0009986; GO:0010332; GO:0016021; GO:0016311; GO:0019887; GO:0019901; GO:0030217; GO:0042100; GO:0042102; GO:0045121; GO:0050852; GO:0050853; GO:0050857; GO:0051209; GO:0051607; GO:0051726 0 0 0 PF12567;PF00041;PF12453;PF00102; P13051 CHOYP_LOC100708100.1.1 m.19627 sp UNG_HUMAN 55.108 323 132 4 13 332 1 313 4.75E-117 343 UNG_HUMAN reviewed Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) UNG DGU UNG1 UNG15 Homo sapiens (Human) 313 "base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; depyrimidination [GO:0045008]; DNA repair [GO:0006281]; negative regulation of apoptotic process [GO:0043066]; positive regulation of isotype switching [GO:0045830]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; viral process [GO:0016032]" GO:0003684; GO:0004844; GO:0005634; GO:0005654; GO:0005739; GO:0006281; GO:0006284; GO:0016032; GO:0016446; GO:0016447; GO:0019899; GO:0043066; GO:0045008; GO:0045830; GO:0097510 0 0 cd10027; PF03167; P23416 CHOYP_LOC100533289.4.6 m.44243 sp GLRA2_HUMAN 45.399 326 173 3 11 333 45 368 4.75E-102 310 GLRA2_HUMAN reviewed Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) 452 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glycinergic [GO:0060012]" GO:0005886; GO:0005887; GO:0007218; GO:0007416; GO:0016594; GO:0016934; GO:0021510; GO:0022852; GO:0030054; GO:0034220; GO:0034707; GO:0042995; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; P31689 CHOYP_LOC100374573.1.1 m.24523 sp DNJA1_HUMAN 65.594 404 125 5 1 398 1 396 4.75E-179 506 DNJA1_HUMAN reviewed DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) DNAJA1 DNAJ2 HDJ2 HSJ2 HSPF4 Homo sapiens (Human) 397 "androgen receptor signaling pathway [GO:0030521]; DNA damage response, detection of DNA damage [GO:0042769]; negative regulation of apoptotic process [GO:0043066]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway [GO:1905259]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of apoptotic process [GO:0043065]; protein folding [GO:0006457]; protein localization to mitochondrion [GO:0070585]; regulation of protein transport [GO:0051223]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986]; spermatogenesis [GO:0007283]; sperm motility [GO:0030317]; toxin transport [GO:1901998]" GO:0001664; GO:0005524; GO:0005634; GO:0005739; GO:0005829; GO:0006457; GO:0006986; GO:0007283; GO:0009408; GO:0016020; GO:0030317; GO:0030521; GO:0030544; GO:0030957; GO:0031397; GO:0031625; GO:0042769; GO:0043065; GO:0043066; GO:0043508; GO:0046872; GO:0048471; GO:0050750; GO:0051087; GO:0051223; GO:0055131; GO:0070062; GO:0070585; GO:0098554; GO:1901998; GO:1903748; GO:1905259 0 0 cd06257; PF00226;PF01556;PF00684; P33015 CHOYP_LOC100891566.1.1 m.25015 sp YEEE_ECOLI 23.496 349 227 13 62 400 10 328 4.75E-06 52 YEEE_ECOLI reviewed UPF0394 inner membrane protein YeeE yeeE b2013 JW1995 Escherichia coli (strain K12) 352 0 GO:0005886; GO:0016021 0 0 0 PF04143; P36975 CHOYP_LOC100533400.1.4 m.12300 sp SNP25_DROME 59.064 171 65 2 14 182 45 212 4.75E-64 199 SNP25_DROME reviewed Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) Snap25 CG40452 Drosophila melanogaster (Fruit fly) 212 Golgi to plasma membrane transport [GO:0006893]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter secretion [GO:0007269]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; synaptic vesicle priming [GO:0016082]; synaptic vesicle transport [GO:0048489]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] GO:0000149; GO:0005484; GO:0005737; GO:0005886; GO:0006893; GO:0006906; GO:0007269; GO:0007274; GO:0016020; GO:0016081; GO:0016082; GO:0016192; GO:0019905; GO:0030054; GO:0031201; GO:0031629; GO:0043195; GO:0048172; GO:0048489 0 0 0 PF00835; P45842 CHOYP_NEMVEDRAFT_V1G237122.3.6 m.18048 sp RL34_AEDAL 69.863 73 22 0 1 73 1 73 4.75E-28 102 RL34_AEDAL reviewed 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01199; P55214 CHOYP_CASP7.10.23 m.26573 sp CASP7_MESAU 44.558 294 144 6 11 294 17 301 4.75E-76 237 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q01844 CHOYP_CC136.1.1 m.64302 sp EWS_HUMAN 42.667 225 96 5 490 685 327 547 4.75E-36 148 EWS_HUMAN reviewed RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein) EWSR1 EWS Homo sapiens (Human) 656 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003723; GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0008270; GO:0042802; GO:0044822 0 0 0 PF00076;PF00641; Q24212 CHOYP_STNB.1.1 m.31521 sp STNB_DROME 47.601 521 241 6 790 1281 714 1231 4.75E-158 510 STNB_DROME reviewed Protein stoned-B (Stn-B) (StonedB) stnB CG12473 Drosophila melanogaster (Fruit fly) 1262 chemical synaptic transmission [GO:0007268]; neurotransmitter secretion [GO:0007269]; regulation of synaptic vesicle endocytosis [GO:1900242]; synaptic vesicle coating [GO:0016183]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle transport [GO:0048489]; vesicle coating [GO:0006901] GO:0005886; GO:0006901; GO:0007268; GO:0007269; GO:0008021; GO:0016183; GO:0030054; GO:0030135; GO:0030139; GO:0048488; GO:0048489; GO:1900242 0 0 0 PF00928; Q2KIK3 CHOYP_SMIM14.2.3 m.50206 sp SIM14_BOVIN 54.167 96 37 3 31 122 5 97 4.75E-28 101 SIM14_BOVIN reviewed Small integral membrane protein 14 SMIM14 Bos taurus (Bovine) 99 0 GO:0005783; GO:0005789; GO:0016021 0 0 0 PF11027; Q5TYW1 CHOYP_LOC101107626.1.1 m.1051 sp ZN658_HUMAN 27.103 642 359 24 654 1279 497 1045 4.75E-40 166 ZN658_HUMAN reviewed Zinc finger protein 658 ZNF658 Homo sapiens (Human) 1059 "cellular response to zinc ion [GO:0071294]; negative regulation of transcription, DNA-templated [GO:0045892]; ribosome biogenesis [GO:0042254]; transcription, DNA-templated [GO:0006351]" GO:0000976; GO:0003700; GO:0005634; GO:0006351; GO:0042254; GO:0045892; GO:0046872; GO:0071294 0 0 cd07765; PF01352;PF00096;PF13912; Q68LP1 CHOYP_LOC100865663.1.1 m.9283 sp MIB2_RAT 25.341 367 201 8 12 360 314 625 4.75E-23 104 MIB2_RAT reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (RBSC-skeletrophin/dystrophin-like polypeptide) Mib2 Rattus norvegicus (Rat) 971 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0005768; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6NRS6 CHOYP_DRAM2.1.2 m.55274 sp DRAM1_XENLA 29.31 232 145 3 15 242 12 228 4.75E-19 86.7 DRAM1_XENLA reviewed DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator) dram1 dram Xenopus laevis (African clawed frog) 239 apoptotic process [GO:0006915]; autophagy [GO:0006914] GO:0005765; GO:0006914; GO:0006915; GO:0016021 0 0 0 PF10277; Q6NZ22 CHOYP_MET14.1.1 m.5073 sp MET14_DANRE 61.125 409 145 5 26 423 1 406 4.75E-180 515 MET14_DANRE reviewed N6-adenosine-methyltransferase subunit METTL14 (EC 2.1.1.62) (Methyltransferase-like protein 14) mettl14 zgc:77296 Danio rerio (Zebrafish) (Brachydanio rerio) 455 "mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; mRNA splicing, via spliceosome [GO:0000398]; RNA methylation [GO:0001510]; stem cell population maintenance [GO:0019827]" GO:0000398; GO:0001510; GO:0003729; GO:0005634; GO:0016422; GO:0019827; GO:0036396; GO:0061157; GO:0080009 0 0 0 PF05063; Q8C525 CHOYP_NEMVEDRAFT_V1G196611.7.13 m.32528 sp M21D2_MOUSE 25 164 115 4 177 339 166 322 4.75E-08 58.2 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8R151 CHOYP_LOC100371500.2.7 m.12995 sp ZNFX1_MOUSE 36.642 816 453 20 19 781 667 1471 4.75E-131 456 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8TER0 CHOYP_LOC574757.2.9 m.21749 sp SNED1_HUMAN 45.578 294 143 3 21 313 26 303 4.75E-71 265 SNED1_HUMAN reviewed "Sushi, nidogen and EGF-like domain-containing protein 1 (Insulin-responsive sequence DNA-binding protein 1) (IRE-BP1)" SNED1 Homo sapiens (Human) 1413 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0070062 0 0 0 PF00008;PF00041;PF12661;PF06119; Q9U639 CHOYP_HSC70.1.1 m.336 sp HSP7D_MANSE 80 145 29 0 8 152 6 150 4.75E-78 246 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; Q9VCA8 CHOYP_LOC580878.1.1 m.39967 sp ANKHM_DROME 35.342 365 218 12 799 1148 653 1014 4.75E-43 176 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9W2N0 CHOYP_GBLP.6.7 m.57427 sp CAPZA_DROME 62.284 289 100 2 7 295 5 284 4.75E-136 389 CAPZA_DROME reviewed F-actin-capping protein subunit alpha cpa CG10540 Drosophila melanogaster (Fruit fly) 286 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; barbed-end actin filament capping [GO:0051016]; cell morphogenesis [GO:0000902]; germarium-derived oocyte fate determination [GO:0007294]; microtubule-based movement [GO:0007018]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of filopodium assembly [GO:0051490]; negative regulation of JNK cascade [GO:0046329]; phagocytosis [GO:0006909]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]; sensory perception of pain [GO:0019233]; wing disc development [GO:0035220] GO:0000902; GO:0005869; GO:0005875; GO:0006909; GO:0007015; GO:0007018; GO:0007294; GO:0008290; GO:0010591; GO:0016324; GO:0019233; GO:0030036; GO:0030837; GO:0035220; GO:0046329; GO:0046982; GO:0051016; GO:0051489; GO:0051490 0 0 0 PF01267; Q9YIC0 CHOYP_EEF1A.2.3 m.20689 sp EF1A_ORYLA 83.065 124 21 0 49 172 270 393 4.75E-67 214 EF1A_ORYLA reviewed Elongation factor 1-alpha (EF-1-alpha) eef1a ef1a Oryzias latipes (Japanese rice fish) (Japanese killifish) 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; A0JPE1 CHOYP_BRAFLDRAFT_86764.1.1 m.4061 sp FA69B_XENTR 28.223 287 189 5 2 281 151 427 4.76E-40 147 FA69B_XENTR reviewed Protein FAM69B fam69b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 431 0 GO:0005789; GO:0016021 0 0 0 PF12260;PF14875; A4IF63 CHOYP_LOC100369333.15.32 m.32599 sp TRIM2_BOVIN 26.442 208 145 4 80 282 540 744 4.76E-13 72.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NMZ7 CHOYP_LOC100708991.5.5 m.59991 sp CO6A6_HUMAN 29.34 409 253 13 45 448 610 987 4.76E-40 157 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; B8ARK7 CHOYP_LOC100632618.2.3 m.30752 sp SIR1_ORYSI 40 240 126 4 138 376 22 244 4.76E-46 169 SIR1_ORYSI reviewed NAD-dependent protein deacetylase SRT1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) SRT1 OsI_15145 Oryza sativa subsp. indica (Rice) 484 0 GO:0005634; GO:0016787; GO:0046872; GO:0070403 0 0 0 PF02146; O15995 CHOYP_LOC100371723.1.1 m.18487 sp CCNE_HEMPU 48.009 427 198 6 1 412 1 418 4.76E-130 385 CCNE_HEMPU reviewed G1/S-specific cyclin-E CYCE Hemicentrotus pulcherrimus (Sea urchin) (Strongylocentrotus pulcherrimus) 424 cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005634; GO:0007049; GO:0051301 0 0 0 PF02984;PF00134; O75478 CHOYP_TAD2A.1.1 m.27477 sp TAD2A_HUMAN 44.344 442 231 7 2 436 9 442 4.76E-122 365 TAD2A_HUMAN reviewed Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) TADA2A TADA2L KL04P Homo sapiens (Human) 443 chromatin remodeling [GO:0006338]; histone H3 acetylation [GO:0043966]; positive regulation of histone acetylation [GO:0035066]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000125; GO:0003677; GO:0003682; GO:0003700; GO:0003712; GO:0003713; GO:0005634; GO:0005694; GO:0006338; GO:0006357; GO:0006366; GO:0035066; GO:0043966 0 0 0 PF00249;PF04433; O97902 CHOYP_LOC100883206.1.1 m.28887 sp ASAP1_BOVIN 40.994 161 90 3 1 159 555 712 4.76E-27 115 ASAP1_BOVIN reviewed "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)" ASAP1 DDEF1 Bos taurus (Bovine) 1129 cilium morphogenesis [GO:0060271] GO:0005096; GO:0005737; GO:0016020; GO:0046872; GO:0060271 0 0 0 PF12796;PF01412;PF00169;PF00018; P21837 CHOYP_BRAFLDRAFT_95718.1.1 m.10095 sp CRYS_DICDI 37.16 514 285 17 29 526 39 530 4.76E-86 279 CRYS_DICDI reviewed Crystal protein cryS DDB_G0285419 Dictyostelium discoideum (Slime mold) 550 0 GO:0033118; GO:0052689 0 0 0 PF00135; P52432 CHOYP_RPAC1.1.1 m.36389 sp RPAC1_MOUSE 66.866 335 109 2 5 337 8 342 4.76E-171 481 RPAC1_MOUSE reviewed DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPC40) Polr1c Rpo1-1 Mus musculus (Mouse) 346 chromatin silencing at rDNA [GO:0000183]; piRNA metabolic process [GO:0034587]; transcription from RNA polymerase III promoter [GO:0006383]; transcription initiation from RNA polymerase I promoter [GO:0006361] GO:0000183; GO:0003677; GO:0003899; GO:0005654; GO:0005666; GO:0005736; GO:0006361; GO:0006383; GO:0034587 0 0 0 PF01000;PF01193; P61857 CHOYP_LOC373275.4.7 m.47552 sp TBB2_DROME 96.053 76 3 0 9 84 212 287 4.76E-47 159 TBB2_DROME reviewed Tubulin beta-2 chain (Beta-2-tubulin) betaTub85D TubB85D CG9359 Drosophila melanogaster (Fruit fly) 446 microtubule-based process [GO:0007017]; salivary gland morphogenesis [GO:0007435] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0007435 0 0 0 PF00091;PF03953; P72745 CHOYP_NEMVEDRAFT_V1G236658.1.6 m.1822 sp Y1101_SYNY3 37.864 103 62 1 51 151 6 108 4.76E-13 64.7 Y1101_SYNY3 reviewed Universal stress protein Slr1101 (USP Slr1101) slr1101 Synechocystis sp. (strain PCC 6803 / Kazusa) 108 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q03650 CHOYP_NEMVEDRAFT_V1G229510.2.4 m.41394 sp CRAM_TRYBB 26.939 490 342 5 9 484 350 837 4.76E-20 97.8 CRAM_TRYBB reviewed "Cysteine-rich, acidic integral membrane protein" CRAM Trypanosoma brucei brucei 945 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021; GO:0020016 0 0 0 PF07016; Q07G10 CHOYP_ALKB8.2.2 m.64314 sp ALKB8_XENTR 45.625 160 86 1 2 161 3 161 4.76E-26 107 ALKB8_XENTR reviewed Alkylated DNA repair protein alkB homolog 8 (EC 1.14.11.-) (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.-) (EC 2.1.1.229) alkbh8 TEgg091o15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 628 oxidation-reduction process [GO:0055114]; tRNA methylation [GO:0030488]; tRNA wobble uridine modification [GO:0002098] GO:0000049; GO:0000166; GO:0002098; GO:0005506; GO:0005634; GO:0005737; GO:0005829; GO:0008198; GO:0008270; GO:0016300; GO:0016706; GO:0030488; GO:0055114 0 0 0 PF13532;PF08241;PF00076; Q5BJ65 CHOYP_H2AV.3.7 m.18795 sp H2AV_XENTR 94.444 126 7 0 1 126 1 126 4.76E-80 234 H2AV_XENTR reviewed Histone H2A.V (H2A.F/Z) h2afv TGas096d24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 chromatin silencing [GO:0006342] GO:0000786; GO:0000790; GO:0003677; GO:0006342 0 0 0 PF00125;PF16211; Q6PA06 CHOYP_ATLA1.2.4 m.44363 sp ATLA2_MOUSE 40.547 439 250 6 41 475 71 502 4.76E-111 343 ATLA2_MOUSE reviewed Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) Atl2 Arl6ip2 Mus musculus (Mouse) 583 endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0007029; GO:0007030; GO:0016020; GO:0016021; GO:0042802; GO:0051260 0 0 0 PF02263; Q8CBY1 CHOYP_SMAG1.1.1 m.54362 sp SMAG1_MOUSE 37.728 766 333 27 6 688 2 706 4.76E-119 375 SMAG1_MOUSE reviewed Protein Smaug homolog 1 (Smaug 1) (mSmaug 1) (Sterile alpha motif domain-containing protein 4A) Samd4a Samd4 Smaug1 Mus musculus (Mouse) 711 "negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of translation [GO:0045727]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000289; GO:0000932; GO:0003729; GO:0006355; GO:0017148; GO:0030054; GO:0030371; GO:0030425; GO:0043488; GO:0044822; GO:0045202; GO:0045727 0 0 0 PF00536; Q8TE60 CHOYP_BRAFLDRAFT_95556.1.2 m.2894 sp ATS18_HUMAN 38.107 391 233 7 2 387 831 1217 4.76E-85 284 ATS18_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAM-TS 18) (ADAM-TS18) (ADAMTS-18) (EC 3.4.24.-) ADAMTS18 ADAMTS21 Homo sapiens (Human) 1221 eye development [GO:0001654]; negative regulation of platelet aggregation [GO:0090331] GO:0001654; GO:0004222; GO:0005578; GO:0008270; GO:0090331 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q920P5 CHOYP_RS14.3.6 m.23056 sp KAD5_MOUSE 31.004 458 270 10 1 445 138 562 4.76E-69 234 KAD5_MOUSE reviewed Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) Ak5 Mus musculus (Mouse) 562 ATP metabolic process [GO:0046034]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142] GO:0004017; GO:0004550; GO:0005524; GO:0005737; GO:0005815; GO:0006165; GO:0009142; GO:0019206; GO:0046034 0 0 cd01428; 0 Q98925 CHOYP_IRF1.3.3 m.59045 sp IRF2_CHICK 53.39 118 52 2 19 133 2 119 4.76E-39 145 IRF2_CHICK reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) 348 cell proliferation [GO:0008283] GO:0000977; GO:0001228; GO:0005654; GO:0005737; GO:0005925; GO:0008283 0 0 0 PF00605; Q99741 CHOYP_BRAFLDRAFT_123390.1.1 m.6961 sp CDC6_HUMAN 53.791 422 183 8 171 585 144 560 4.76E-146 436 CDC6_HUMAN reviewed Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6) CDC6 CDC18L Homo sapiens (Human) 560 cell division [GO:0051301]; cellular response to angiotensin [GO:1904385]; cellular response to vasopressin [GO:1904117]; DNA replication [GO:0006260]; DNA replication checkpoint [GO:0000076]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; positive regulation of chromosome segregation [GO:0051984]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytokinesis [GO:0032467]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; traversing start control point of mitotic cell cycle [GO:0007089] GO:0000076; GO:0000079; GO:0000082; GO:0000083; GO:0000166; GO:0000922; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0006260; GO:0006270; GO:0007067; GO:0007089; GO:0008156; GO:0008285; GO:0019900; GO:0030071; GO:0032467; GO:0045737; GO:0048146; GO:0051233; GO:0051301; GO:0051984; GO:1904117; GO:1904385 0 0 cd08768; PF13401;PF09079; Q99M80 CHOYP_LOC100877739.1.1 m.41289 sp PTPRT_MOUSE 36.429 280 163 7 1120 1393 891 1161 4.76E-45 182 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BY08 CHOYP_EBPL.1.1 m.6610 sp EBPL_HUMAN 59.538 173 69 1 29 201 33 204 4.76E-68 210 EBPL_HUMAN reviewed Emopamil-binding protein-like (Emopamil-binding-related protein) EBPL EBRP ERP Homo sapiens (Human) 206 sterol metabolic process [GO:0016125] GO:0005783; GO:0005789; GO:0016021; GO:0016125; GO:0047750 0 0 0 PF05241; Q9ESQ4 CHOYP_LOC100679140.1.1 m.38919 sp NMUR2_RAT 27.119 236 145 7 108 332 111 330 4.76E-09 60.8 NMUR2_RAT reviewed Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor TGR-1) (G-protein-coupled receptor FM-4) Nmur2 Tgr1 Rattus norvegicus (Rat) 395 activation of phospholipase A2 activity by calcium-mediated signaling [GO:0043006]; arachidonic acid secretion [GO:0050482]; calcium ion transport [GO:0006816]; central nervous system development [GO:0007417]; grooming behavior [GO:0007625]; inositol phosphate-mediated signaling [GO:0048016]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; reduction of food intake in response to dietary excess [GO:0002023]; response to pain [GO:0048265] GO:0001607; GO:0002023; GO:0005229; GO:0005525; GO:0005829; GO:0005886; GO:0006816; GO:0007200; GO:0007204; GO:0007417; GO:0007625; GO:0008188; GO:0016021; GO:0042924; GO:0043006; GO:0048016; GO:0048265; GO:0050482 0 0 0 PF00001; Q9Y2L5 CHOYP_TRAPPC8.1.1 m.12318 sp TPPC8_HUMAN 36.792 106 63 2 4 108 1060 1162 4.76E-13 68.2 TPPC8_HUMAN reviewed Trafficking protein particle complex subunit 8 (Protein TRS85 homolog) TRAPPC8 KIAA1012 Homo sapiens (Human) 1435 autophagosome assembly [GO:0000045]; CVT pathway [GO:0032258]; ER to Golgi vesicle-mediated transport [GO:0006888]; nucleophagy [GO:0044804]; pexophagy [GO:0030242]; protein localization to pre-autophagosomal structure [GO:0034497] GO:0000045; GO:0000407; GO:0006888; GO:0030242; GO:0031410; GO:0032258; GO:0034497; GO:0044804; GO:1990072 0 0 0 PF12739; B2GUZ1 CHOYP_USP15.1.2 m.58978 sp UBP4_RAT 51.429 105 47 2 1 104 126 227 4.77E-26 113 UBP4_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) Usp4 Rattus norvegicus (Rat) 961 negative regulation of protein ubiquitination [GO:0031397]; protein deubiquitination [GO:0016579]; protein localization to cell surface [GO:0034394]; regulation of protein stability [GO:0031647]; spliceosomal tri-snRNP complex assembly [GO:0000244]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000244; GO:0004843; GO:0005634; GO:0005737; GO:0005886; GO:0006511; GO:0016579; GO:0031397; GO:0031647; GO:0034394; GO:0046872 0 0 0 PF06337;PF14836;PF00443; D4A8G9 CHOYP_LOC100373252.1.1 m.40090 sp ZFY26_RAT 31.429 175 98 6 11 175 3 165 4.77E-11 67.8 ZFY26_RAT reviewed Zinc finger FYVE domain-containing protein 26 Zfyve26 Rattus norvegicus (Rat) 2542 cytokinesis [GO:0000910]; double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0000910; GO:0005737; GO:0005813; GO:0030496; GO:0032266; GO:0046872 0 0 0 PF01363; E1B7L7 CHOYP_LOC100370569.1.1 m.15643 sp UBN2_BOVIN 45.306 245 123 6 329 572 446 680 4.77E-55 213 UBN2_BOVIN reviewed Ubinuclein-2 UBN2 Bos taurus (Bovine) 1330 0 GO:0005634 0 0 0 PF08729;PF14075; O14490 CHOYP_DLGP1.1.3 m.25370 sp DLGP1_HUMAN 45.133 113 61 1 125 237 791 902 4.77E-26 111 DLGP1_HUMAN reviewed Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) DLGAP1 DAP1 GKAP Homo sapiens (Human) 977 chemical synaptic transmission [GO:0007268] GO:0007268; GO:0014069; GO:0030054; GO:0045211 0 0 0 PF03359; O94880 CHOYP_PHF14.1.1 m.27257 sp PHF14_HUMAN 44.073 658 330 15 75 712 246 885 4.77E-174 525 PHF14_HUMAN reviewed PHD finger protein 14 PHF14 KIAA0783 Homo sapiens (Human) 888 lung alveolus development [GO:0048286]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122] GO:0000122; GO:0005634; GO:0008270; GO:0048286; GO:2000584; GO:2000791 0 0 0 PF00628; P19984 CHOYP_CAOG_01521.1.1 m.28103 sp PROF2_ACACA 28.829 111 66 4 3 112 2 100 4.77E-07 48.9 PROF2_ACACA reviewed Profilin-2 (Basic profilin) (Profilin II) 0 Acanthamoeba castellanii (Amoeba) 126 0 GO:0005737; GO:0005856 0 0 0 PF00235; P24540 CHOYP_LOC101065571.2.2 m.61020 sp ACYP1_PIG 42.857 91 52 0 6 96 9 99 4.77E-23 88.2 ACYP1_PIG reviewed "Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1)" ACYP1 ACYPE Sus scrofa (Pig) 101 0 GO:0003998 0 0 0 PF00708; P32320 CHOYP_LOC100693418.2.2 m.56971 sp CDD_HUMAN 47.368 95 50 0 7 101 52 146 4.77E-27 99.8 CDD_HUMAN reviewed Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) CDA CDD Homo sapiens (Human) 146 cell surface receptor signaling pathway [GO:0007166]; cytidine deamination [GO:0009972]; cytosine metabolic process [GO:0019858]; negative regulation of cell growth [GO:0030308]; negative regulation of nucleotide metabolic process [GO:0045980]; protein homotetramerization [GO:0051289]; pyrimidine-containing compound salvage [GO:0008655]; pyrimidine nucleoside salvage [GO:0043097] GO:0001882; GO:0004126; GO:0005576; GO:0005829; GO:0007166; GO:0008270; GO:0008655; GO:0009972; GO:0019858; GO:0030308; GO:0042803; GO:0043097; GO:0045980; GO:0051289 0 0 0 PF00383; P41436 CHOYP_LOC726172.1.1 m.46833 sp IAP_GVCPM 47.674 86 45 0 8 93 102 187 4.77E-26 102 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P42577 CHOYP_LOC100533455.1.9 m.3607 sp FRIS_LYMST 82.036 167 30 0 21 187 1 167 4.77E-101 291 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; Q4L208 CHOYP_LOC100159032.1.1 m.14934 sp SL9A8_RAT 55.603 473 205 4 160 628 102 573 4.77E-177 518 SL9A8_RAT reviewed Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) Slc9a8 Nhe8 Rattus norvegicus (Rat) 575 regulation of pH [GO:0006885] GO:0000139; GO:0006885; GO:0015385; GO:0016021 0 0 0 PF00999; Q5R4Q3 CHOYP_SEC62.2.3 m.22035 sp SEC62_PONAB 39.221 385 200 6 140 502 4 376 4.77E-68 227 SEC62_PONAB reviewed Translocation protein SEC62 (Translocation protein 1) (TP-1) SEC62 TLOC1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 399 posttranslational protein targeting to membrane [GO:0006620] GO:0005789; GO:0005791; GO:0006620; GO:0008565; GO:0016021; GO:0016235; GO:0045111 0 0 0 PF03839; Q69ZS0 CHOYP_LOC100370549.1.1 m.30259 sp PZRN3_MOUSE 27.74 292 159 12 1 245 1 287 4.77E-16 82.8 PZRN3_MOUSE reviewed E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) Pdzrn3 Kiaa1095 Semcap3 Mus musculus (Mouse) 1063 neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] GO:0004842; GO:0007528; GO:0008270; GO:0016567; GO:0016874; GO:0031594; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00595; Q6NRW5 CHOYP_CO041.1.1 m.19366 sp CO041_XENLA 52.672 262 121 2 18 278 21 280 4.77E-100 297 CO041_XENLA reviewed Uncharacterized protein C15orf41 homolog 0 Xenopus laevis (African clawed frog) 303 0 0 0 0 0 PF14811; Q8BHT6 CHOYP_LOC100670231.1.1 m.6369 sp B3GLT_MOUSE 48.206 446 223 7 52 494 44 484 4.77E-141 418 B3GLT_MOUSE reviewed "Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (Beta 3-glucosyltransferase) (Beta-3-glycosyltransferase-like)" B3glct B3galtl Gm1057 Mus musculus (Mouse) 489 fucose metabolic process [GO:0006004]; protein glycosylation [GO:0006486] GO:0005789; GO:0006004; GO:0006486; GO:0016021; GO:0016757 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02434; Q9C040 CHOYP_ZF_BBOX_RING_-1.7.10 m.51127 sp TRIM2_HUMAN 31.169 154 85 5 8 149 15 159 4.77E-14 79 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JKB5 CHOYP_ARI4B.1.1 m.56056 sp ARI4B_RAT 46.683 407 186 9 2 388 3 398 4.77E-89 320 ARI4B_RAT reviewed AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1) Arid4b Rbbp1l1 Sap180 Rattus norvegicus (Rat) 1228 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006357; GO:0044212 0 0 0 PF01388;PF08169; Q9R0A8 CHOYP_LOC100374365.1.2 m.5388 sp HAUS1_RAT 27.358 212 153 1 1 211 4 215 4.77E-25 102 HAUS1_RAT reviewed HAUS augmin-like complex subunit 1 (Coiled-coil domain-containing protein 5) Haus1 Ccdc5 Rattus norvegicus (Rat) 278 cell division [GO:0051301]; centrosome organization [GO:0051297]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0000922; GO:0005737; GO:0005815; GO:0005874; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 0 Q9WTS5 CHOYP_LOC100369350.6.6 m.64941 sp TEN2_MOUSE 34.615 208 99 13 3 187 656 849 4.77E-14 82.8 TEN2_MOUSE reviewed "Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]" Tenm2 Kiaa1127 Odz2 Tnm2 Mus musculus (Mouse) 2764 "axon guidance [GO:0007411]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of filopodium assembly [GO:0051491]; self proteolysis [GO:0097264]; single organismal cell-cell adhesion [GO:0016337]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005102; GO:0005634; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0005911; GO:0006351; GO:0007157; GO:0007411; GO:0016337; GO:0016605; GO:0030054; GO:0030175; GO:0030425; GO:0030426; GO:0035584; GO:0042803; GO:0043005; GO:0043197; GO:0045202; GO:0045211; GO:0046982; GO:0050839; GO:0051491; GO:0097264 0 0 0 PF06484;PF15636; A4QND0 CHOYP_UBL4A.1.2 m.11644 sp UBL4A_XENTR 39.063 128 64 1 25 152 17 130 4.78E-24 94.4 UBL4A_XENTR reviewed Ubiquitin-like protein 4A ubl4a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 148 tail-anchored membrane protein insertion into ER membrane [GO:0071816]; transport [GO:0006810] GO:0005829; GO:0006810; GO:0071816; GO:0071818 0 0 0 PF00240; D3YXG0 CHOYP_BRAFLDRAFT_85664.2.10 m.9436 sp HMCN1_MOUSE 40.21 286 156 6 9 283 4529 4810 4.78E-53 194 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; F1LZF0 CHOYP_KLHL2.3.3 m.45408 sp KLHL2_RAT 22.636 349 235 9 103 437 3 330 4.78E-20 97.4 KLHL2_RAT reviewed Kelch-like protein 2 (Mayven) Klhl2 Rattus norvegicus (Rat) 593 protein ubiquitination [GO:0016567] GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0031463 0 0 0 PF07707;PF00651;PF01344; O13395 CHOYP_LOC100641628.1.3 m.34810 sp CHS6_USTMA 31.716 268 139 11 228 462 526 782 4.78E-22 106 CHS6_USTMA reviewed Chitin synthase 6 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 6) (Class-V chitin synthase 6) CHS6 UMAG_10367 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 1180 cell wall organization [GO:0071555] GO:0003677; GO:0004100; GO:0005886; GO:0016021; GO:0030659; GO:0071555 0 0 0 PF00173;PF08766; P04323 CHOYP_LOC580404.3.3 m.51358 sp POL3_DROME 40.909 418 231 7 741 1148 168 579 4.78E-88 311 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P18101 CHOYP_LOC100695843.2.4 m.24141 sp RL40_DROME 96.471 85 2 1 1 85 37 120 4.78E-56 173 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; Q03601 CHOYP_BRAFLDRAFT_87291.2.4 m.37235 sp NHL1_CAEEL 33.036 112 54 5 221 314 772 880 4.78E-06 53.1 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q0VFH9 CHOYP_BRAFLDRAFT_198761.1.1 m.16370 sp NKAI3_XENTR 46.667 180 87 4 18 195 9 181 4.78E-53 172 NKAI3_XENTR reviewed Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3) nkain3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 181 regulation of sodium ion transport [GO:0002028] GO:0002028; GO:0005886; GO:0016021 0 0 0 PF05640; Q5ND28 CHOYP_CED1.6.29 m.24776 sp SREC_MOUSE 32.512 203 109 10 193 376 152 345 4.78E-15 80.5 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5SV06 CHOYP_NEMVEDRAFT_V1G242484.1.1 m.45790 sp SPT22_MOUSE 41.441 111 64 1 396 506 232 341 4.78E-20 95.1 SPT22_MOUSE reviewed Spermatogenesis-associated protein 22 Spata22 Gm882 Repro42 Mus musculus (Mouse) 358 fertilization [GO:0009566]; gamete generation [GO:0007276]; meiotic DNA repair synthesis [GO:0000711]; regulation of meiotic cell cycle [GO:0051445]; reproductive system development [GO:0061458]; synapsis [GO:0007129] GO:0000711; GO:0005694; GO:0007129; GO:0007276; GO:0009566; GO:0051445; GO:0061458 0 0 0 0 Q5UQ13 CHOYP_COL4A4.1.1 m.30919 sp COLL2_MIMIV 45.918 98 53 0 1 98 913 1010 4.78E-12 68.2 COLL2_MIMIV reviewed Collagen-like protein 2 MIMI_R196 Acanthamoeba polyphaga mimivirus (APMV) 1595 0 GO:0019012 0 0 0 PF01391; Q6ZSM3 CHOYP_MOT5.1.2 m.5647 sp MOT12_HUMAN 30.088 226 151 2 20 245 5 223 4.78E-30 122 MOT12_HUMAN reviewed Monocarboxylate transporter 12 (MCT 12) (Creatine transporter 2) (CRT2) (Solute carrier family 16 member 12) SLC16A12 MCT12 Homo sapiens (Human) 486 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q7ZUB2 CHOYP_RS17.7.11 m.23228 sp RS17_COTJA 82 100 17 1 1 100 7 105 4.78E-54 168 RS17_COTJA reviewed 40S ribosomal protein S17 RPS17 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 135 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00833; Q92506 CHOYP_BRAFLDRAFT_281754.1.1 m.27604 sp DHB8_HUMAN 49.802 253 119 1 17 261 9 261 4.78E-88 265 DHB8_HUMAN reviewed Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239) HSD17B8 FABGL HKE6 RING2 SDR30C1 Homo sapiens (Human) 261 androgen metabolic process [GO:0008209]; estrogen biosynthetic process [GO:0006703]; fatty acid biosynthetic process [GO:0006633]; steroid biosynthetic process [GO:0006694] GO:0003857; GO:0004303; GO:0005740; GO:0005759; GO:0005886; GO:0006633; GO:0006694; GO:0006703; GO:0008209; GO:0047035 PATHWAY: Steroid biosynthesis; estrogen biosynthesis.; PATHWAY: Lipid metabolism; fatty acid biosynthesis. 0 0 0 Q96PZ2 CHOYP_BRAFLDRAFT_79380.1.3 m.13575 sp F111A_HUMAN 25.862 290 148 12 327 585 344 597 4.78E-06 53.5 F111A_HUMAN reviewed Protein FAM111A FAM111A KIAA1895 Homo sapiens (Human) 611 defense response to virus [GO:0051607]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071] GO:0000785; GO:0005634; GO:0005737; GO:0006260; GO:0045071; GO:0051607 0 0 0 0 Q96RW7 CHOYP_AGAP_AGAP001239.1.1 m.26778 sp HMCN1_HUMAN 26.904 197 117 4 50 246 4165 4334 4.78E-09 61.2 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9ESN6 CHOYP_LOC100369754.7.10 m.60670 sp TRIM2_MOUSE 22.601 469 307 20 88 514 273 727 4.78E-10 65.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P32100 CHOYP_RPL7.2.2 m.49809 sp RL7_DROME 71.186 118 33 1 1 117 135 252 4.79E-59 185 RL7_DROME reviewed 60S ribosomal protein L7 RpL7 CG4897 Drosophila melanogaster (Fruit fly) 252 "centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; pupariation [GO:0035073]" GO:0000022; GO:0000463; GO:0002181; GO:0003735; GO:0005840; GO:0007052; GO:0022625; GO:0035073; GO:0044822; GO:0051298 0 0 0 PF00327;PF08079; P38661 CHOYP_PDIA6.2.2 m.58490 sp PDIA6_MEDSA 26.688 311 214 8 59 359 58 364 4.79E-23 103 PDIA6_MEDSA reviewed Probable protein disulfide-isomerase A6 (EC 5.3.4.1) (P5) 0 Medicago sativa (Alfalfa) 364 cell redox homeostasis [GO:0045454] GO:0003756; GO:0005788; GO:0045454 0 0 cd00238; PF07749;PF00085; P62282 CHOYP_LOC101068140.2.2 m.50569 sp RS11_RAT 67.29 107 33 2 1 105 1 107 4.79E-46 149 RS11_RAT reviewed 40S ribosomal protein S11 Rps11 Rattus norvegicus (Rat) 158 osteoblast differentiation [GO:0001649]; translation [GO:0006412] GO:0001649; GO:0003735; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022627; GO:0044822; GO:0070062 0 0 0 PF00366;PF16205; P86854 CHOYP_PLCL.6.8 m.64296 sp PLCL_MYTGA 26.282 156 101 7 3 156 5 148 4.79E-09 55.8 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q08BC4 CHOYP_LOC100374155.1.1 m.56570 sp STPG2_DANRE 41.873 566 297 16 1 560 1 540 4.79E-128 390 STPG2_DANRE reviewed Sperm-tail PG-rich repeat-containing protein 2 stpg2 zgc:153987 Danio rerio (Zebrafish) (Brachydanio rerio) 562 0 0 0 0 0 PF07004; Q5BIM1 CHOYP_LOC100157373.1.1 m.51867 sp TRI45_BOVIN 22.422 223 155 6 1 213 123 337 4.79E-09 62.8 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5BIR5 CHOYP_SPB3.1.1 m.31072 sp SPB8_BOVIN 40 375 214 7 15 381 3 374 4.79E-88 273 SPB8_BOVIN reviewed Serpin B8 SERPINB8 Bos taurus (Bovine) 374 0 GO:0004867; GO:0005615; GO:0005737; GO:0005829; GO:0070062 0 0 0 PF00079; Q5RBP9 CHOYP_MPEG1.1.5 m.15132 sp MPEG1_PONAB 38.85 713 382 17 32 720 8 690 4.79E-159 479 MPEG1_PONAB reviewed Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 716 0 GO:0016021 0 0 0 PF01823; Q6RFZ7 CHOYP_BRAFLDRAFT_124569.1.1 m.57872 sp PKHG5_RAT 38.038 744 372 18 316 1002 7 718 4.79E-142 462 PKHG5_RAT reviewed Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Neuronal RhoA GEF protein) (Transcript highly enriched in cortex and hippocampus) Plekhg5 Tech Rattus norvegicus (Rat) 1039 endothelial cell chemotaxis [GO:0035767]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005737; GO:0005886; GO:0005911; GO:0030027; GO:0030139; GO:0035023; GO:0035767; GO:0048471 0 0 0 PF00621; Q75WE7 CHOYP_VWA5A.1.1 m.59943 sp VWA5A_RAT 32.316 786 445 18 9 720 1 773 4.79E-122 387 VWA5A_RAT reviewed von Willebrand factor A domain-containing protein 5A (Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog) (Mast cell surface antigen 1) (Masa-1) Vwa5a Loh11cr2a Masa1 Rattus norvegicus (Rat) 822 0 0 0 0 0 PF08487;PF13768; Q7Z3E1 CHOYP_PAR14.5.17 m.33163 sp PARPT_HUMAN 39.394 198 111 4 41 235 450 641 4.79E-35 134 PARPT_HUMAN reviewed TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 14) (ARTD14) (Poly [ADP-ribose] polymerase 7) (PARP-7) TIPARP PARP7 Homo sapiens (Human) 657 androgen metabolic process [GO:0008209]; cellular response to organic cyclic compound [GO:0071407]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; female gonad development [GO:0008585]; hemopoiesis [GO:0030097]; kidney development [GO:0001822]; multicellular organism metabolic process [GO:0044236]; negative regulation of gene expression [GO:0010629]; nitrogen compound metabolic process [GO:0006807]; palate development [GO:0060021]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of protein catabolic process [GO:0045732]; post-embryonic development [GO:0009791]; protein ADP-ribosylation [GO:0006471]; skeletal system morphogenesis [GO:0048705]; smooth muscle tissue development [GO:0048745]; vasculogenesis [GO:0001570] GO:0001570; GO:0001822; GO:0003950; GO:0005634; GO:0006471; GO:0006807; GO:0008209; GO:0008210; GO:0008585; GO:0009791; GO:0010629; GO:0030097; GO:0035326; GO:0044236; GO:0045732; GO:0046872; GO:0048008; GO:0048705; GO:0048745; GO:0060021; GO:0060325; GO:0071407 0 0 0 PF00644; Q8CE13 CHOYP_BRAFLDRAFT_126355.1.2 m.34322 sp CCD17_MOUSE 25.73 548 352 14 1 521 1 520 4.79E-33 139 CCD17_MOUSE reviewed Coiled-coil domain-containing protein 17 Ccdc17 Mus musculus (Mouse) 565 0 0 0 0 0 0 Q8IWZ3 CHOYP_ANK1.1.8 m.42 sp ANKH1_HUMAN 32.474 194 116 9 16 198 373 562 4.79E-16 79.3 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q9C0I9 CHOYP_LOC756946.1.1 m.49284 sp LRC27_HUMAN 28.98 490 282 18 77 531 47 505 4.79E-35 141 LRC27_HUMAN reviewed Leucine-rich repeat-containing protein 27 LRRC27 KIAA1674 Homo sapiens (Human) 530 0 0 0 0 0 PF13855; Q9GLY5 CHOYP_ITIH3.1.3 m.21735 sp ITIH3_RABIT 37.454 809 452 21 27 806 45 828 4.79E-155 481 ITIH3_RABIT reviewed Inter-alpha-trypsin inhibitor heavy chain H3 (ITI heavy chain H3) (ITI-HC3) (Inter-alpha-inhibitor heavy chain 3) ITIH3 Oryctolagus cuniculus (Rabbit) 903 hyaluronan metabolic process [GO:0030212] GO:0004867; GO:0005576; GO:0030212 0 0 0 PF06668;PF08487;PF00092; Q9GPR3 CHOYP_LOC100375740.1.2 m.27116 sp TM2D1_DICDI 49.231 65 33 0 331 395 2 66 4.79E-13 70.1 TM2D1_DICDI reviewed TM2 domain-containing protein DDB_G0277895 DDB_G0277895 Dictyostelium discoideum (Slime mold) 153 0 GO:0016021 0 0 0 PF05154; O70277 CHOYP_BRAFLDRAFT_87292.5.6 m.58186 sp TRIM3_RAT 25.185 135 99 1 133 265 599 733 4.80E-07 54.3 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75095 CHOYP_CED1.26.29 m.53629 sp MEGF6_HUMAN 38.406 276 150 13 177 451 817 1073 4.80E-33 138 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75179 CHOYP_LOC762964.4.10 m.26005 sp ANR17_HUMAN 28.182 550 314 15 1181 1717 208 689 4.80E-38 160 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75179 CHOYP_PLE7327_4008.1.1 m.45025 sp ANR17_HUMAN 37.156 218 129 6 1 212 439 654 4.80E-29 117 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_BRAFLDRAFT_110072.1.8 m.390 sp TRIM3_HUMAN 24.034 233 136 9 83 296 534 744 4.80E-07 54.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P48430 CHOYP_PHUM_PHUM361660.1.1 m.63424 sp SOX2_CHICK 59.813 214 59 7 51 238 12 224 4.80E-65 208 SOX2_CHICK reviewed Transcription factor SOX-2 (cSox2) (delta EF2a) SOX2 Gallus gallus (Chicken) 315 "cell cycle arrest [GO:0007050]; endodermal cell fate specification [GO:0001714]; eye development [GO:0001654]; inner ear development [GO:0048839]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuron differentiation [GO:0045665]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; response to growth factor [GO:0070848]; response to wounding [GO:0009611]; sensory organ precursor cell fate determination [GO:0016360]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]" GO:0001649; GO:0001654; GO:0001714; GO:0003700; GO:0005623; GO:0005634; GO:0005654; GO:0005829; GO:0006351; GO:0007050; GO:0009611; GO:0016360; GO:0021983; GO:0035019; GO:0035198; GO:0043281; GO:0043410; GO:0043565; GO:0044212; GO:0045665; GO:0045893; GO:0045944; GO:0048839; GO:0050680; GO:0070848; GO:0090090 0 0 0 PF00505;PF12336; Q3UMZ3 CHOYP_PPC1B.1.1 m.24784 sp PLPP5_MOUSE 52.301 239 112 2 3 239 2 240 4.80E-77 237 PLPP5_MOUSE reviewed Phospholipid phosphatase 5 (EC 3.1.3.4) (Phosphatidic acid phosphatase type 2 domain-containing protein 1B) Plpp5 Ppapdc1 Ppapdc1b Mus musculus (Mouse) 260 phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165] GO:0005887; GO:0006644; GO:0007165; GO:0008195; GO:0046839 0 0 0 PF01569; Q3ZBG9 CHOYP_SPT5H.1.1 m.60055 sp PLS2_BOVIN 56.272 279 98 5 1 269 24 288 4.80E-103 305 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q40588 CHOYP_LOC100376857.1.7 m.30171 sp ASO_TOBAC 29.085 612 315 18 96 678 45 566 4.80E-62 222 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q55E58 CHOYP_BRAFLDRAFT_129004.12.15 m.47968 sp PATS1_DICDI 26.573 286 167 10 494 778 1793 2036 4.80E-17 90.9 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5JXM2 CHOYP_LOC100375376.2.2 m.54772 sp MET24_HUMAN 26.16 237 145 7 341 548 131 366 4.80E-13 74.3 MET24_HUMAN reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) METTL24 C6orf186 Homo sapiens (Human) 366 0 GO:0005576; GO:0008168 0 0 0 PF13383; Q6DJN2 CHOYP_LOC100703551.1.1 m.15765 sp TRF6B_XENLA 51.351 111 51 2 69 178 56 164 4.80E-33 126 TRF6B_XENLA reviewed TNF receptor-associated factor 6-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF6) traf6-b Xenopus laevis (African clawed frog) 556 activation of NF-kappaB-inducing kinase activity [GO:0007250]; immune response [GO:0006955]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981] GO:0004842; GO:0005737; GO:0006955; GO:0007250; GO:0008270; GO:0016874; GO:0042981; GO:0070534 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02176; Q6R7H1 CHOYP_DPSE_GA29245.1.1 m.9596 sp Y054_OSHVF 23.438 256 158 12 2 240 324 558 4.80E-06 52.8 Y054_OSHVF reviewed Uncharacterized protein ORF54 ORF54 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 807 0 GO:0016021; GO:0033644 0 0 0 0 Q7LHG5 CHOYP_contig_020391 m.23601 sp YI31B_YEAST 22.756 479 276 16 26 470 616 1034 4.80E-21 102 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q8BPG6 CHOYP_LOC100370684.1.2 m.61028 sp SUMF2_MOUSE 50.598 251 117 2 2 252 58 301 4.80E-84 257 SUMF2_MOUSE reviewed Sulfatase-modifying factor 2 (C-alpha-formylglycine-generating enzyme 2) Sumf2 Mus musculus (Mouse) 308 0 GO:0005783; GO:0005788; GO:0042803; GO:0046872 0 0 0 PF03781; Q95029 CHOYP_LOC100206725.1.1 m.22845 sp CATL_DROME 59.425 313 113 3 47 345 59 371 4.80E-133 387 CATL_DROME reviewed Cathepsin L (EC 3.4.22.15) (Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] Cp1 fs(2)50Ca CG6692 Drosophila melanogaster (Fruit fly) 371 autophagic cell death [GO:0048102]; digestion [GO:0007586]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; salivary gland cell autophagic cell death [GO:0035071] GO:0004197; GO:0005615; GO:0005764; GO:0006508; GO:0007586; GO:0008233; GO:0035071; GO:0045169; GO:0048102; GO:0051603 0 0 0 PF08246;PF00112; Q9BRZ2 CHOYP_NEMVEDRAFT_V1G142847.1.1 m.34202 sp TRI56_HUMAN 23.737 198 125 4 9 192 12 197 4.80E-11 65.9 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9TTS3 CHOYP_ACACA.7.7 m.63941 sp ACACA_BOVIN 66.977 215 66 1 3 212 1554 1768 4.80E-94 303 ACACA_BOVIN reviewed Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACACA ACAC ACCA Bos taurus (Bovine) 2346 acetyl-CoA metabolic process [GO:0006084]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289] GO:0003989; GO:0004075; GO:0005524; GO:0005829; GO:0006084; GO:0006633; GO:0046872; GO:0051289; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; O08585 CHOYP_CLCA.1.1 m.15484 sp CLCA_MOUSE 47.093 172 67 3 20 169 65 234 4.81E-47 156 CLCA_MOUSE reviewed Clathrin light chain A (Lca) Clta Mus musculus (Mouse) 235 clathrin-mediated endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] GO:0005198; GO:0006886; GO:0016020; GO:0016023; GO:0030125; GO:0030130; GO:0030132; GO:0032050; GO:0043231; GO:0071439; GO:0072583 0 0 0 PF01086; O08863 CHOYP_BIRC3.5.7 m.47816 sp BIRC3_MOUSE 29.022 634 369 21 187 791 19 600 4.81E-60 217 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; O35737 CHOYP_LOC100377054.1.1 m.8489 sp HNRH1_MOUSE 60.088 228 76 4 34 255 9 227 4.81E-81 263 HNRH1_MOUSE reviewed "Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]" Hnrnph1 Hnrph Hnrph1 Mus musculus (Mouse) 449 mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005654; GO:0005737; GO:0006397; GO:0008380; GO:0016020; GO:0043484; GO:0044822; GO:0071013 0 0 0 PF00076;PF08080; O50655 CHOYP_LOC100635540.1.7 m.10040 sp XERD_SELRU 22.876 306 215 7 60 358 47 338 4.81E-15 79 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O54879 CHOYP_LOC778718.1.1 m.29230 sp HMGB3_MOUSE 41.463 164 80 5 25 175 14 174 4.81E-26 102 HMGB3_MOUSE reviewed High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) Hmgb3 Hmg2a Hmg4 Mus musculus (Mouse) 200 "DNA geometric change [GO:0032392]; innate immune response [GO:0045087]; negative regulation of B cell differentiation [GO:0045578]; negative regulation of myeloid cell differentiation [GO:0045638]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000400; GO:0003677; GO:0003723; GO:0005634; GO:0005694; GO:0005737; GO:0006351; GO:0006355; GO:0008301; GO:0032392; GO:0045087; GO:0045578; GO:0045638 0 0 0 PF00505;PF09011; O94759 CHOYP_LOC100622032.3.3 m.63183 sp TRPM2_HUMAN 28.659 492 293 14 558 1015 622 1089 4.81E-40 165 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; P26697 CHOYP_BRAFLDRAFT_216204.1.1 m.30654 sp GSTA3_CHICK 42.13 216 119 4 11 222 7 220 4.81E-47 158 GSTA3_CHICK reviewed Glutathione S-transferase 3 (EC 2.5.1.18) (GST class-alpha) (GST-CL3) 0 Gallus gallus (Chicken) 229 glutathione metabolic process [GO:0006749] GO:0004364; GO:0005737; GO:0006749 0 0 0 PF14497;PF02798; P59222 CHOYP_LOC101077597.2.3 m.25843 sp SREC2_MOUSE 33.333 132 81 4 158 289 234 358 4.81E-08 58.5 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P79781 CHOYP_ABCF2.1.2 m.28362 sp RS27A_CHICK 95.513 156 7 0 1 156 1 156 4.81E-96 276 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; Q2PW47 CHOYP_MED24.4.10 m.16709 sp MED24_DANRE 34.709 533 318 11 1 512 434 957 4.81E-87 292 MED24_DANRE reviewed Mediator of RNA polymerase II transcription subunit 24 (Mediator complex subunit 24) (Protein lessen) (Thyroid hormone receptor-associated protein 4 homolog) (Trap100 homolog) med24 lsn thrap4 trap100 Danio rerio (Zebrafish) (Brachydanio rerio) 989 "enteric nervous system development [GO:0048484]; interstitial cell of Cajal differentiation [GO:0061453]; retinal cone cell development [GO:0046549]; thymus development [GO:0048538]; transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592; GO:0046549; GO:0048484; GO:0048538; GO:0061453 0 0 0 PF11277; Q52KB5 CHOYP_LOC100186203.1.1 m.7875 sp ZBT24_DANRE 32.143 196 114 4 202 393 221 401 4.81E-17 90.5 ZBT24_DANRE reviewed Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) zbtb24 zfp450 zgc:194556 Danio rerio (Zebrafish) (Brachydanio rerio) 672 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF00096; Q5NC57 CHOYP_LOC100185469.1.2 m.17559 sp F183B_MOUSE 53.846 117 54 0 92 208 14 130 4.81E-33 119 F183B_MOUSE reviewed Protein FAM183B Fam183b Mus musculus (Mouse) 135 0 0 0 0 0 PF14886; Q5R9Y3 CHOYP_LOC591612.2.2 m.52079 sp ABT1_PONAB 44.961 129 62 1 45 173 105 224 4.81E-36 129 ABT1_PONAB reviewed Activator of basal transcription 1 ABT1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 272 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0003723; GO:0005730; GO:0006351; GO:0006355 0 0 0 0 Q5RJ80 CHOYP_LOC101066959.2.2 m.36009 sp CAPR2_DANRE 35.556 135 75 5 238 367 784 911 4.81E-12 70.9 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q6V7V2 CHOYP_LOC581809.2.2 m.32091 sp RTKN_RAT 41.479 311 148 6 30 318 7 305 4.81E-72 235 RTKN_RAT reviewed Rhotekin Rtkn Rattus norvegicus (Rat) 548 apoptotic process [GO:0006915]; Rho protein signal transduction [GO:0007266] GO:0005095; GO:0005525; GO:0005622; GO:0006915; GO:0007266; GO:0017049 0 0 0 PF08174; Q6VFT6 CHOYP_LOC100136214.1.1 m.15333 sp FOXL2_PIG 89.362 94 10 0 122 215 51 144 4.81E-55 188 FOXL2_PIG reviewed Forkhead box protein L2 FOXL2 Sus scrofa (Pig) 377 "apoptotic DNA fragmentation [GO:0006309]; embryonic eye morphogenesis [GO:0048048]; extraocular skeletal muscle development [GO:0002074]; female somatic sex determination [GO:0019101]; granulosa cell differentiation [GO:0060014]; menstruation [GO:0042703]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; oocyte growth [GO:0001555]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; single fertilization [GO:0007338]; uterus development [GO:0060065]" GO:0000122; GO:0000978; GO:0000981; GO:0001077; GO:0001541; GO:0001555; GO:0002074; GO:0003677; GO:0003700; GO:0005634; GO:0006309; GO:0007338; GO:0019101; GO:0033686; GO:0042703; GO:0043028; GO:0043065; GO:0043280; GO:0045893; GO:0045944; GO:0046881; GO:0048048; GO:0060014; GO:0060065 0 0 0 PF00250; Q6XPS3 CHOYP_LOC101074730.1.1 m.13029 sp TPTE2_HUMAN 42.735 468 251 6 81 541 62 519 4.81E-122 372 TPTE2_HUMAN reviewed "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)" TPTE2 TPIP Homo sapiens (Human) 522 phosphatidylinositol biosynthetic process [GO:0006661] GO:0000139; GO:0004725; GO:0005789; GO:0006661; GO:0008138; GO:0016021; GO:0016314; GO:0051800 0 0 0 PF00782;PF10409; Q7KRY7 CHOYP_BRAFLDRAFT_198676.1.1 m.15813 sp LAP4_DROME 39.189 518 273 12 102 595 930 1429 4.81E-86 302 LAP4_DROME reviewed Protein lap4 (Protein scribble) (Protein smell-impaired) scrib smi vart CG5462 Drosophila melanogaster (Fruit fly) 1851 "anterior/posterior axis specification, follicular epithelium [GO:0030714]; asymmetric protein localization [GO:0008105]; cell fate commitment involved in pattern specification [GO:0060581]; cell fate specification [GO:0001708]; cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; compound eye development [GO:0048749]; dorsal closure [GO:0007391]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; Malpighian tubule development [GO:0072002]; morphogenesis of a polarized epithelium [GO:0001738]; morphogenesis of embryonic epithelium [GO:0016331]; morphogenesis of follicular epithelium [GO:0016333]; morphogenesis of larval imaginal disc epithelium [GO:0016335]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; olfactory behavior [GO:0042048]; ovarian follicle cell development [GO:0030707]; pole plasm protein localization [GO:0007318]; positive regulation of heart contraction [GO:0045823]; R3/R4 cell fate commitment [GO:0007464]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of JAK-STAT cascade [GO:0046425]; regulation of Notch signaling pathway [GO:0008593]; regulation of synapse structure or activity [GO:0050803]; sensory perception of smell [GO:0007608]; septate junction assembly [GO:0019991]; stem cell differentiation [GO:0048863]; stem cell proliferation [GO:0072089]; wing disc morphogenesis [GO:0007472]; zonula adherens assembly [GO:0045186]" GO:0000122; GO:0000902; GO:0001708; GO:0001737; GO:0001738; GO:0005179; GO:0005576; GO:0005918; GO:0005923; GO:0007318; GO:0007391; GO:0007464; GO:0007472; GO:0007608; GO:0008105; GO:0008283; GO:0008285; GO:0008593; GO:0016323; GO:0016327; GO:0016328; GO:0016331; GO:0016332; GO:0016333; GO:0016334; GO:0016335; GO:0016336; GO:0019991; GO:0030100; GO:0030707; GO:0030714; GO:0031594; GO:0035088; GO:0042048; GO:0042058; GO:0042067; GO:0045169; GO:0045186; GO:0045197; GO:0045198; GO:0045571; GO:0045823; GO:0046425; GO:0048749; GO:0048863; GO:0050680; GO:0050803; GO:0051726; GO:0060581; GO:0072002; GO:0072089 0 0 0 PF13855;PF00595; Q8BGF7 CHOYP_PAN2.1.1 m.44690 sp PAN2_MOUSE 47.719 570 290 6 87 652 62 627 4.81E-171 545 PAN2_MOUSE reviewed PAB-dependent poly(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-nuclease) (PAN deadenylation complex catalytic subunit 2) Pan2 Kiaa0710 Usp52 Mus musculus (Mouse) 1200 "mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of cytoplasmic mRNA processing body assembly [GO:0010606]" GO:0000175; GO:0000289; GO:0000291; GO:0000932; GO:0003676; GO:0004535; GO:0005634; GO:0005737; GO:0006397; GO:0010606; GO:0031251 0 0 0 PF00929;PF13423; Q96I24 CHOYP_BRAFLDRAFT_124476.2.4 m.11928 sp FUBP3_HUMAN 38.14 215 85 7 8 183 352 557 4.81E-27 109 FUBP3_HUMAN reviewed Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) 572 "positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0001077; GO:0005634; GO:0005737; GO:0006351; GO:0010628; GO:0016020; GO:0044822; GO:0045893; GO:0045944 0 0 0 PF00013; Q96S44 CHOYP_LOC100375324.1.1 m.45919 sp PRPK_HUMAN 52.679 224 100 3 16 238 35 253 4.81E-79 241 PRPK_HUMAN reviewed TP53-regulating kinase (EC 2.7.11.1) (Atypical serine/threonine protein kinase TP53RK) (EKC/KEOPS complex subunit TP53RK) (EC 3.6.-.-) (Nori-2) (p53-related protein kinase) TP53RK C20orf64 PRPK Homo sapiens (Human) 253 protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525] GO:0000408; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005829; GO:0006468; GO:0008033; GO:0016020; GO:0016787; GO:0070525; GO:1901796 0 0 0 PF06293; Q9XWB9 CHOYP_CRE_06883.1.1 m.52272 sp BAT36_CAEEL 32.692 104 64 3 45 148 157 254 4.81E-09 60.1 BAT36_CAEEL reviewed BTB and MATH domain-containing protein 36 bath-36 Y75B12B.4 Caenorhabditis elegans 320 0 0 0 0 0 PF00651;PF00917; A1Z9X0 CHOYP_LOC100533284.2.2 m.44775 sp APKC_DROME 74.026 154 40 0 1 154 453 606 4.82E-79 248 APKC_DROME reviewed Atypical protein kinase C (EC 2.7.11.13) aPKC CG30475 Drosophila melanogaster (Fruit fly) 606 "adherens junction organization [GO:0034332]; apical protein localization [GO:0045176]; asymmetric neuroblast division [GO:0055059]; asymmetric protein localization involved in cell fate determination [GO:0045167]; branching involved in open tracheal system development [GO:0060446]; cell-cell junction assembly [GO:0007043]; compound eye retinal cell programmed cell death [GO:0046667]; epithelial cell morphogenesis [GO:0003382]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of epithelial cell planar polarity [GO:0090163]; establishment of mitotic spindle orientation [GO:0000132]; establishment or maintenance of cell polarity [GO:0007163]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; establishment or maintenance of neuroblast polarity [GO:0045196]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; establishment or maintenance of polarity of follicular epithelium [GO:0016334]; exocyst localization [GO:0051601]; germarium-derived oocyte fate determination [GO:0007294]; intracellular signal transduction [GO:0035556]; maintenance of cell polarity [GO:0030011]; melanotic encapsulation of foreign target [GO:0035011]; memory [GO:0007613]; morphogenesis of a polarized epithelium [GO:0001738]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte axis specification [GO:0007309]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuroblast proliferation [GO:0002052]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; sensory organ development [GO:0007423]; spermatogenesis [GO:0007283]; synapse assembly [GO:0007416]; terminal branching, open tracheal system [GO:0007430]; zonula adherens assembly [GO:0045186]" GO:0000132; GO:0001738; GO:0002052; GO:0003382; GO:0004674; GO:0004697; GO:0005524; GO:0005938; GO:0006468; GO:0007043; GO:0007163; GO:0007283; GO:0007294; GO:0007309; GO:0007314; GO:0007416; GO:0007423; GO:0007430; GO:0007613; GO:0010592; GO:0016324; GO:0016327; GO:0016332; GO:0016334; GO:0017022; GO:0030011; GO:0034332; GO:0035003; GO:0035011; GO:0035556; GO:0045167; GO:0045176; GO:0045179; GO:0045186; GO:0045196; GO:0045197; GO:0045198; GO:0046667; GO:0046872; GO:0051491; GO:0051601; GO:0055059; GO:0060446; GO:0072659; GO:0090163 0 0 0 PF00130;PF00564;PF00069;PF00433; A3KPW9 CHOYP_BAG6A.1.1 m.25802 sp BAG6_DANRE 29.764 467 298 10 877 1331 711 1159 4.82E-57 220 BAG6_DANRE reviewed Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3) Bag6 Bat3 si:ch211-215a10.6 Danio rerio (Zebrafish) (Brachydanio rerio) 1160 brain development [GO:0007420]; covalent chromatin modification [GO:0016569]; embryo development [GO:0009790]; internal peptidyl-lysine acetylation [GO:0018393]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; kidney development [GO:0001822]; lung development [GO:0030324]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of proteolysis [GO:0045861]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; transport [GO:0006810]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001822; GO:0005634; GO:0005829; GO:0006511; GO:0006810; GO:0007130; GO:0007283; GO:0007420; GO:0009790; GO:0016569; GO:0018393; GO:0030324; GO:0031593; GO:0032435; GO:0042771; GO:0042981; GO:0043022; GO:0045861; GO:0050821; GO:0070059; GO:0070628; GO:0071816; GO:0071818 0 0 0 PF12057;PF00240; P22897 CHOYP_LOC100699850.1.3 m.3523 sp MRC1_HUMAN 30.51 1098 685 35 1279 2340 329 1384 4.82E-140 481 MRC1_HUMAN reviewed Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0001618; GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0005887; GO:0006898; GO:0009986; GO:0010008; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q00420 CHOYP_LOC100369954.1.1 m.22656 sp GABP1_MOUSE 65.341 176 60 1 67 241 1 176 4.82E-76 248 GABP1_MOUSE reviewed GA-binding protein subunit beta-1 (GABP subunit beta-1) (GABPB-1) (GABP subunit beta-2) (GABPB-2) Gabpb1 Gabpb Gabpb2 Mus musculus (Mouse) 383 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0044212; GO:0045944; GO:0046982 0 0 0 PF12796; Q0EEE2 CHOYP_LOC100372915.6.7 m.65765 sp PTHD3_MOUSE 34.375 352 216 6 4 344 557 904 4.82E-60 211 PTHD3_MOUSE reviewed Patched domain-containing protein 3 (RND-type protein RNDEu-3) Ptchd3 Mus musculus (Mouse) 906 0 GO:0016021; GO:0097225 0 0 0 PF02460; Q17QH8 CHOYP_D39U1.1.1 m.29364 sp D39U1_BOVIN 45.875 303 153 4 4 305 1 293 4.82E-93 280 D39U1_BOVIN reviewed Epimerase family protein SDR39U1 (EC 1.1.1.-) (Short-chain dehydrogenase/reductase family 39U member 1) SDR39U1 Bos taurus (Bovine) 294 0 GO:0016491; GO:0050662 0 0 0 PF08338;PF01370; Q502B3 CHOYP_B3GL2.1.2 m.10183 sp B3GL2_DANRE 47.826 184 92 2 2 184 310 490 4.82E-60 197 B3GL2_DANRE reviewed "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (Beta-1,3-GalNAc-T2) (EC 2.4.1.-) (Beta-1,3-N-acetylgalactosaminyltransferase II)" b3galnt2 zgc:112351 Danio rerio (Zebrafish) (Brachydanio rerio) 491 muscle fiber development [GO:0048747]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493] GO:0000139; GO:0005783; GO:0006486; GO:0006493; GO:0008375; GO:0008376; GO:0008378; GO:0016021; GO:0048747 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q6IR41 CHOYP_LOC100697720.2.2 m.65567 sp C1QT6_MOUSE 35.088 114 66 3 255 365 148 256 4.82E-06 51.2 C1QT6_MOUSE reviewed Complement C1q tumor necrosis factor-related protein 6 C1qtnf6 Mus musculus (Mouse) 264 protein heterotrimerization [GO:0070208]; protein oligomerization [GO:0051259] GO:0005581; GO:0005615; GO:0042802; GO:0051259; GO:0070208 0 0 0 PF00386;PF01391; Q76KD6 CHOYP_TVAG_198570.4.8 m.48458 sp SPERI_HUMAN 34.579 107 57 3 871 975 444 539 4.82E-09 63.9 SPERI_HUMAN reviewed Speriolin (Spermatogenesis and centriole-associated protein 1) (Spermatogenesis-associated protein 15) (Spermatogenic cell-specific Cdc20-binding protein) SPATC1 SPATA15 SPRN Homo sapiens (Human) 591 0 GO:0005737; GO:0005813 0 0 0 PF15059;PF15058; Q8K5B3 CHOYP_LOC756261.1.1 m.12395 sp MCFD2_RAT 32.911 158 79 7 1 155 7 140 4.82E-17 78.6 MCFD2_RAT reviewed Multiple coagulation factor deficiency protein 2 homolog (Neural stem cell-derived neuronal survival protein) Mcfd2 Sdnsf Rattus norvegicus (Rat) 145 brain development [GO:0007420]; carboxylic acid metabolic process [GO:0019752]; negative regulation of cell death [GO:0060548]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005509; GO:0005576; GO:0005783; GO:0005793; GO:0005794; GO:0007420; GO:0015031; GO:0016192; GO:0019752; GO:0060548 0 0 0 PF13499; Q8WUA2 CHOYP_LOC100368924.1.1 m.5032 sp PPIL4_HUMAN 67.932 237 76 0 1 237 1 237 4.82E-113 335 PPIL4_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) PPIL4 Homo sapiens (Human) 492 protein folding [GO:0006457] GO:0000166; GO:0003755; GO:0005654; GO:0005737; GO:0006457; GO:0044822 0 0 0 PF00160;PF00076; Q91WC1 CHOYP_POTE1.1.1 m.49585 sp POTE1_MOUSE 27.843 510 287 10 46 544 6 445 4.82E-56 204 POTE1_MOUSE reviewed Protection of telomeres protein 1 (mPot1) (POT1-like telomere end-binding protein) Pot1 Pot1a Mus musculus (Mouse) 640 chromosome organization [GO:0051276]; DNA duplex unwinding [GO:0032508]; establishment of protein localization to telomere [GO:0070200]; negative regulation of telomerase activity [GO:0051974]; positive regulation of DNA strand elongation [GO:0060383]; positive regulation of helicase activity [GO:0051096]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of telomere maintenance via telomerase [GO:0032210]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]; telomere maintenance via telomerase [GO:0007004] GO:0000781; GO:0000783; GO:0000784; GO:0005634; GO:0005654; GO:0007004; GO:0010521; GO:0016233; GO:0017151; GO:0032202; GO:0032210; GO:0032212; GO:0032508; GO:0042162; GO:0043047; GO:0051096; GO:0051276; GO:0051973; GO:0051974; GO:0060383; GO:0070187; GO:0070200; GO:0098505 0 0 0 PF02765;PF16686; Q9NUV9 CHOYP_GIMA7.2.4 m.30591 sp GIMA4_HUMAN 37.813 320 174 8 134 450 30 327 4.82E-59 199 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; A9JTP3 CHOYP_BIRC7.5.5 m.61715 sp BIRC7_XENTR 38.849 417 187 9 248 649 1 364 4.83E-85 274 BIRC7_XENTR reviewed Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP) (Embryonic/Egg IAP) (EIAP/XLX) birc7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 365 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865]; regulation of signal transduction [GO:0009966] GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0007275; GO:0008270; GO:0009966; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865; GO:0090307; GO:1990001 0 0 0 PF00653; B4EX94 CHOYP_contig_034918 m.39615 sp BETA_PROMH 46.377 69 34 1 45 110 3 71 4.83E-14 70.1 BETA_PROMH reviewed Oxygen-dependent choline dehydrogenase (CDH) (CHD) (EC 1.1.99.1) (Betaine aldehyde dehydrogenase) (BADH) (EC 1.2.1.8) betA PMI1459 Proteus mirabilis (strain HI4320) 555 glycine betaine biosynthetic process from choline [GO:0019285] GO:0008802; GO:0008812; GO:0019285; GO:0050660 PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00750}. 0 0 PF05199;PF00732; E6ZHJ8 CHOYP_FXL15.3.3 m.58480 sp FXL15_DICLA 37.918 269 167 0 28 296 12 280 4.83E-57 190 FXL15_DICLA reviewed F-box/LRR-repeat protein 15 fbxl15 DLA_Ib03740 DLA_Ib03750 Dicentrarchus labrax (European seabass) (Morone labrax) 292 bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000086; GO:0005737; GO:0009953; GO:0016567; GO:0019005; GO:0030282; GO:0030513; GO:0031146 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00646;PF13516; Q13507 CHOYP_TRPC7.1.1 m.38695 sp TRPC3_HUMAN 28.777 834 487 23 23 809 28 801 4.83E-112 367 TRPC3_HUMAN reviewed Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3) TRPC3 TRP3 Homo sapiens (Human) 836 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; manganese ion transport [GO:0006828]; phototransduction [GO:0007602]; platelet activation [GO:0030168]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; single fertilization [GO:0007338] GO:0005262; GO:0005886; GO:0005887; GO:0006816; GO:0006828; GO:0007338; GO:0007602; GO:0010524; GO:0015279; GO:0030168; GO:0033198; GO:0051592; GO:0070588; GO:0070679; GO:1903244 0 0 0 PF12796;PF00520;PF08344; Q566Y1 CHOYP_BRAFLDRAFT_124325.1.1 m.16583 sp ELP4_DANRE 48.378 370 162 6 21 372 17 375 4.83E-110 331 ELP4_DANRE reviewed Elongator complex protein 4 (ELP4) elp4 si:dkey-157g7.1 zgc:112389 Danio rerio (Zebrafish) (Brachydanio rerio) 397 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006357; GO:0008023; GO:0008607; GO:0033588 0 0 0 PF05625; Q5USV7 CHOYP_GDF8.1.3 m.10336 sp GDF8_AEPME 33.152 368 210 13 70 428 35 375 4.83E-54 187 GDF8_AEPME reviewed Growth/differentiation factor 8 (GDF-8) (Myostatin) MSTN GDF8 Aepyceros melampus (Impala) 375 growth [GO:0040007] GO:0005615; GO:0008201; GO:0040007 0 0 0 PF00019;PF00688; Q7RTU5 CHOYP_LOC100021445.1.1 m.12194 sp ASCL5_HUMAN 56.061 66 29 0 47 112 153 218 4.83E-17 80.5 ASCL5_HUMAN reviewed Achaete-scute homolog 5 (ASH-5) (hASH5) (Class A basic helix-loop-helix protein 47) (bHLHa47) ASCL5 BHLHA47 Homo sapiens (Human) 278 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0006351; GO:0006357; GO:0090575 0 0 0 PF00010; Q8C525 CHOYP_LOC100377311.9.14 m.42330 sp M21D2_MOUSE 24.852 169 118 5 87 254 162 322 4.83E-07 55.8 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8CIV2 CHOYP_LOC100712483.1.1 m.16213 sp MBRL_MOUSE 71.605 324 75 3 265 587 194 501 4.83E-164 490 MBRL_MOUSE reviewed Membralin (Transmembrane protein 259) Tmem259 ORF61 Mus musculus (Mouse) 574 negative regulation of neuron death [GO:1901215]; positive regulation of ERAD pathway [GO:1904294]; response to endoplasmic reticulum stress [GO:0034976] GO:0005783; GO:0005789; GO:0016021; GO:0034976; GO:1901215; GO:1904294 0 0 0 PF09746; Q8MPM1 CHOYP_LOC100533528.1.2 m.15271 sp GELS2_LUMTE 52.419 372 170 4 1 371 1 366 4.83E-133 387 GELS2_LUMTE reviewed Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) 366 actin filament capping [GO:0051693] GO:0005737; GO:0005856; GO:0051693 0 0 0 PF00626; Q8QGX4 CHOYP_BRAFLDRAFT_85202.2.2 m.48139 sp PRKDC_CHICK 45.568 643 318 13 1 627 663 1289 4.83E-175 555 PRKDC_CHICK reviewed DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) PRKDC XRCC7 Gallus gallus (Chicken) 4134 DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431] GO:0000724; GO:0003677; GO:0004677; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006281; GO:0006303; GO:0016301; GO:0070419; GO:0072431 0 0 0 PF02259;PF02260;PF08163;PF00454; Q9D4J7 CHOYP_PPN.4.4 m.64476 sp PHF6_MOUSE 42.857 133 55 5 8 136 211 326 4.83E-21 99.4 PHF6_MOUSE reviewed PHD finger protein 6 Phf6 Kiaa1823 Mus musculus (Mouse) 364 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000777; GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0008270; GO:0015631; GO:0019899; GO:0042393; GO:0042826; GO:0043021; GO:0044822; GO:0051219; GO:0097110 0 0 0 0 Q9ESN6 CHOYP_contig_051550 m.61654 sp TRIM2_MOUSE 22.772 202 141 4 111 302 547 743 4.83E-07 54.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JKR5 CHOYP_BRAFLDRAFT_117157.3.3 m.53391 sp ZDHC2_RAT 49.558 339 161 3 12 345 16 349 4.83E-125 367 ZDHC2_RAT reviewed Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) Zdhhc2 Srec Rattus norvegicus (Rat) 366 protein palmitoylation [GO:0018345] GO:0005783; GO:0005794; GO:0005887; GO:0008270; GO:0018345; GO:0019706; GO:0055038 0 0 0 PF01529; Q9R001 CHOYP_LOC100770235.1.1 m.2514 sp ATS5_MOUSE 25.873 487 305 19 3 470 407 856 4.83E-34 140 ATS5_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (ADMP-2) (Aggrecanase-2) (Implantin) Adamts5 Mus musculus (Mouse) 930 defense response to bacterium [GO:0042742] GO:0004222; GO:0005578; GO:0005615; GO:0008201; GO:0008237; GO:0008270; GO:0042742; GO:0050840 0 0 0 PF05986;PF01562;PF01421;PF00090; Q9UM22 CHOYP_LOC100329078.2.3 m.30776 sp EPDR1_HUMAN 28.931 159 100 5 36 190 26 175 4.83E-11 63.5 EPDR1_HUMAN reviewed Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; Q9VVS4 CHOYP_LOC100369524.1.1 m.8160 sp MED11_DROME 52.174 115 54 1 11 124 4 118 4.83E-34 119 MED11_DROME reviewed Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11) (dMED21) MED11 Med21 CG6884 Drosophila melanogaster (Fruit fly) 176 dendrite morphogenesis [GO:0048813]; muscle organ development [GO:0007517]; negative regulation of neuroblast proliferation [GO:0007406]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription from RNA polymerase II promoter [GO:0006366] GO:0001104; GO:0003713; GO:0005634; GO:0006357; GO:0006366; GO:0007406; GO:0007517; GO:0016592; GO:0048813 0 0 0 PF10280; A4D2P6 CHOYP_LOC100370362.1.1 m.10753 sp GRD2I_HUMAN 40.909 374 201 5 1 365 828 1190 4.84E-84 280 GRD2I_HUMAN reviewed "Delphilin (Glutamate receptor, ionotropic, delta 2-interacting protein 1)" GRID2IP Homo sapiens (Human) 1211 long term synaptic depression [GO:0060292] GO:0030054; GO:0043197; GO:0045211; GO:0060292 0 0 0 PF02181;PF00595; H2A0M7 CHOYP_PLSP.1.5 m.17000 sp PLSP_PINMG 48.857 350 149 8 2 344 383 709 4.84E-85 276 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; P02707 CHOYP_LOC100368595.1.3 m.22184 sp LECH_CHICK 35.156 128 80 3 375 500 78 204 4.84E-21 94.7 LECH_CHICK reviewed Hepatic lectin 0 Gallus gallus (Chicken) 207 endocytosis [GO:0006897] GO:0006897; GO:0016021; GO:0030246 0 0 0 PF00059; P18101 CHOYP_RL40.4.7 m.25351 sp RL40_DROME 68.794 141 31 2 1 141 1 128 4.84E-60 184 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; P50416 CHOYP_LOC100647521.1.2 m.21487 sp CPT1A_HUMAN 62.774 274 101 1 3 275 159 432 4.84E-124 374 CPT1A_HUMAN reviewed "Carnitine O-palmitoyltransferase 1, liver isoform (CPT1-L) (EC 2.3.1.21) (Carnitine O-palmitoyltransferase I, liver isoform) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A)" CPT1A CPT1 Homo sapiens (Human) 773 carnitine metabolic process [GO:0009437]; carnitine shuttle [GO:0006853]; cellular response to fatty acid [GO:0071398]; circadian rhythm [GO:0007623]; eating behavior [GO:0042755]; epithelial cell differentiation [GO:0030855]; fatty acid beta-oxidation [GO:0006635]; glucose metabolic process [GO:0006006]; long-chain fatty acid metabolic process [GO:0001676]; positive regulation of fatty acid beta-oxidation [GO:0032000]; protein homooligomerization [GO:0051260]; regulation of insulin secretion [GO:0050796]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; triglyceride metabolic process [GO:0006641] GO:0001676; GO:0004095; GO:0005739; GO:0005741; GO:0005743; GO:0006006; GO:0006635; GO:0006641; GO:0006853; GO:0007623; GO:0009437; GO:0014070; GO:0016020; GO:0030855; GO:0031307; GO:0032000; GO:0042493; GO:0042755; GO:0050796; GO:0051260; GO:0071398; GO:1990698 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00755;PF16484; P60897 CHOYP_LOC100891402.2.3 m.27268 sp DSS1_MOUSE 79.104 67 13 1 168 234 3 68 4.84E-17 76.3 DSS1_MOUSE reviewed 26S proteasome complex subunit DSS1 (Deleted in split hand/split foot protein 1 homolog) (Split hand/foot deleted protein 1 homolog) (Split hand/foot malformation type 1 protein homolog) Shfm1 Dss1 Shfdg1 Mus musculus (Mouse) 70 double-strand break repair via homologous recombination [GO:0000724]; mRNA export from nucleus [GO:0006406]; proteasome assembly [GO:0043248]; proteolysis [GO:0006508] GO:0000502; GO:0000724; GO:0006406; GO:0006508; GO:0008541; GO:0043248 0 0 0 PF05160; Q1RMK1 CHOYP_BRAFLDRAFT_57402.2.3 m.22491 sp FA92B_BOVIN 48.416 221 112 1 3 223 6 224 4.84E-73 231 FA92B_BOVIN reviewed Protein FAM92B FAM92B Bos taurus (Bovine) 288 0 0 0 0 0 PF06730; Q499P8 CHOYP_ZGC_162613.1.1 m.20307 sp RUS1_RAT 46.891 386 203 2 43 428 74 457 4.84E-108 329 RUS1_RAT reviewed RUS1 family protein C16orf58 homolog 0 Rattus norvegicus (Rat) 466 0 GO:0016021 0 0 0 PF04884; Q4PMB3 CHOYP_LOC100371488.1.1 m.12177 sp RS4_IXOSC 77.654 179 40 0 2 180 67 245 4.84E-103 301 RS4_IXOSC reviewed 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) 262 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q5XIA9 CHOYP_LOC100186733.1.1 m.7066 sp KLD8B_RAT 37.861 346 203 4 6 342 9 351 4.84E-83 258 KLD8B_RAT reviewed Kelch domain-containing protein 8B Klhdc8b Rattus norvegicus (Rat) 354 0 GO:0005737 0 0 0 PF01344; Q60865 CHOYP_BRAFLDRAFT_128819.1.1 m.63322 sp CAPR1_MOUSE 32.468 616 325 23 20 562 52 649 4.84E-62 222 CAPR1_MOUSE reviewed Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) Caprin1 Gpiap Gpiap1 Gpip137 M11s1 Rng105 G5E5 Mus musculus (Mouse) 707 negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003] GO:0000932; GO:0003723; GO:0005737; GO:0005829; GO:0010494; GO:0016020; GO:0017148; GO:0030425; GO:0044822; GO:0050775; GO:0061003 0 0 0 PF12287; Q6P0U3 CHOYP_RSLBB.1.2 m.1608 sp RSLBB_DANRE 40.571 175 98 2 21 189 14 188 4.84E-40 140 RSLBB_DANRE reviewed Ras-like protein family member 11B rasl11b Danio rerio (Zebrafish) (Brachydanio rerio) 244 mesendoderm development [GO:0048382]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0016020; GO:0048382 0 0 0 PF00071; Q6PFY8 CHOYP_LOC100374741.49.83 m.42424 sp TRI45_MOUSE 24.354 271 182 9 11 264 133 397 4.84E-09 62 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q91614 CHOYP_LOC100181213.1.1 m.9 sp NCS1_XENLA 65.217 184 64 0 1 184 1 184 4.84E-85 251 NCS1_XENLA reviewed Neuronal calcium sensor 1 (NCS-1) (Frequenin) ncs1 freq Xenopus laevis (African clawed frog) 190 regulation of neuron projection development [GO:0010975] GO:0005245; GO:0005509; GO:0005794; GO:0010975; GO:0014069; GO:0030054; GO:0045211; GO:0048471 0 0 0 PF00036;PF13499; Q96GY0 CHOYP_ZC21A.3.3 m.64780 sp ZC21A_HUMAN 50 190 92 3 18 207 18 204 4.84E-44 160 ZC21A_HUMAN reviewed Zinc finger C2HC domain-containing protein 1A ZC2HC1A C8orf70 FAM164A CGI-62 Homo sapiens (Human) 325 0 GO:0046872 0 0 0 0 Q99KE8 CHOYP_XFIN.1.4 m.606 sp ZFP64_MOUSE 21.622 370 262 8 340 693 195 552 4.84E-15 84.7 ZFP64_MOUSE reviewed Zinc finger protein 64 (Zfp-64) Zfp64 Mus musculus (Mouse) 643 "multicellular organism development [GO:0007275]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0032728; GO:0032755; GO:0032760; GO:0046872; GO:0048026 0 0 0 0 Q9ERH8 CHOYP_LOC100369565.2.2 m.19007 sp S28A3_MOUSE 62.385 218 82 0 8 225 264 481 4.84E-90 282 S28A3_MOUSE reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (mCNT3) Slc28a3 Cnt3 Mus musculus (Mouse) 703 purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]; retina homeostasis [GO:0001895] GO:0001895; GO:0005887; GO:0015389; GO:0015390; GO:0015860; GO:0015864 0 0 0 PF07670;PF07662;PF01773; Q9GLK0 CHOYP_NEMVEDRAFT_V1G97278.1.2 m.34546 sp TGM1_CANLF 36.963 698 423 9 55 748 101 785 4.84E-155 474 TGM1_CANLF reviewed Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) TGM1 Canis lupus familiaris (Dog) (Canis familiaris) 815 keratinization [GO:0031424]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838] GO:0003810; GO:0010838; GO:0016020; GO:0018149; GO:0031424; GO:0045787; GO:0046872 0 0 0 PF00927;PF01841;PF00868; Q9Y6N9 CHOYP_WHRN.1.2 m.44307 sp USH1C_HUMAN 27.5 200 121 2 254 429 85 284 4.84E-13 74.7 USH1C_HUMAN reviewed Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) USH1C AIE75 Homo sapiens (Human) 552 brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; cellular protein complex assembly [GO:0043623]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; regulation of microvillus length [GO:0032532]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0000086; GO:0001750; GO:0001917; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005902; GO:0005903; GO:0007605; GO:0030154; GO:0030507; GO:0032420; GO:0032532; GO:0043623; GO:0045177; GO:0045202; GO:0045494; GO:0050953; GO:0050957; GO:1904106; GO:1904970 0 0 0 PF00595; O88866 CHOYP_RS2.6.10 m.37377 sp HUNK_MOUSE 54.545 209 91 2 41 245 56 264 4.85E-74 241 HUNK_MOUSE reviewed Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) Hunk Makv Mus musculus (Mouse) 714 intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0035556 0 0 0 PF00069; P20749 CHOYP_BCL3.1.2 m.56007 sp BCL3_HUMAN 37.124 299 157 7 272 542 26 321 4.85E-41 160 BCL3_HUMAN reviewed B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3) BCL3 BCL4 D19S37 Homo sapiens (Human) 454 "antimicrobial humoral response [GO:0019730]; cellular response to DNA damage stimulus [GO:0006974]; defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; humoral immune response mediated by circulating immunoglobulin [GO:0002455]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; marginal zone B cell differentiation [GO:0002315]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-8 biosynthetic process [GO:0045415]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of tumor necrosis factor biosynthetic process [GO:0042536]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 biosynthetic process [GO:0045082]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of translation [GO:0045727]; protein import into nucleus, translocation [GO:0000060]; regulation of apoptotic process [GO:0042981]; regulation of DNA binding [GO:0051101]; regulation of NF-kappaB import into nucleus [GO:0042345]; response to UV-C [GO:0010225]; response to virus [GO:0009615]; spleen development [GO:0048536]; T-helper 1 type immune response [GO:0042088]; T-helper 2 cell differentiation [GO:0045064]; transcription, DNA-templated [GO:0006351]" GO:0000060; GO:0002268; GO:0002315; GO:0002455; GO:0002467; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006974; GO:0007249; GO:0008134; GO:0009615; GO:0010225; GO:0019730; GO:0030198; GO:0030330; GO:0030674; GO:0032729; GO:0032996; GO:0033257; GO:0042088; GO:0042345; GO:0042536; GO:0042742; GO:0042771; GO:0042832; GO:0042981; GO:0043066; GO:0043234; GO:0045064; GO:0045082; GO:0045171; GO:0045415; GO:0045727; GO:0045892; GO:0045893; GO:0045944; GO:0048471; GO:0048536; GO:0051101; GO:0051457 0 0 0 PF12796; Q24307 CHOYP_BIRC2.10.13 m.55466 sp DIAP2_DROME 31.609 348 205 9 772 1110 174 497 4.85E-42 165 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q29496 CHOYP_CYP3A89.1.1 m.53245 sp CP3AO_SHEEP 34.638 511 314 11 8 515 3 496 4.85E-102 318 CP3AO_SHEEP reviewed Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) 503 0 GO:0004497; GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q5T3F8 CHOYP_TMEM63B.1.2 m.37918 sp CSCL2_HUMAN 33.421 763 466 21 39 772 38 787 4.85E-117 376 CSCL2_HUMAN reviewed CSC1-like protein 2 (Transmembrane protein 63B) TMEM63B C6orf110 Homo sapiens (Human) 832 ion transport [GO:0006811] GO:0000166; GO:0005886; GO:0006811; GO:0015629; GO:0016021 0 0 0 PF14703;PF02714;PF13967; Q6DRM0 CHOYP_WRB.1.1 m.24410 sp WRB_DANRE 38.312 154 95 0 7 160 10 163 4.85E-36 126 WRB_DANRE reviewed Tail-anchored protein insertion receptor WRB (Tryptophan-rich basic protein) (WRB) wrb Danio rerio (Zebrafish) (Brachydanio rerio) 170 heart development [GO:0007507]; retina development in camera-type eye [GO:0060041]; tail-anchored membrane protein insertion into ER membrane [GO:0071816] GO:0005789; GO:0007507; GO:0016021; GO:0060041; GO:0071816 0 0 0 PF04420; Q6UX07 CHOYP_LOC586040.1.1 m.53751 sp DHR13_HUMAN 31.383 188 119 5 4 181 161 348 4.85E-23 97.8 DHR13_HUMAN reviewed Dehydrogenase/reductase SDR family member 13 (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 7C member 5) DHRS13 SDR7C5 UNQ419/PRO853 Homo sapiens (Human) 377 0 GO:0005576; GO:0016020; GO:0016491 0 0 0 PF00106; Q6ZMT9 CHOYP_LOC584665.1.1 m.28760 sp DTHD1_HUMAN 23.95 643 417 19 357 988 184 765 4.85E-36 150 DTHD1_HUMAN reviewed Death domain-containing protein 1 DTHD1 Homo sapiens (Human) 781 signal transduction [GO:0007165] GO:0005634; GO:0007165 0 0 0 PF00531; Q810U3 CHOYP_LOC100901941.3.3 m.58475 sp NFASC_MOUSE 26.429 280 176 12 5 265 12 280 4.85E-14 75.5 NFASC_MOUSE reviewed Neurofascin Nfasc Mus musculus (Mouse) 1240 axon guidance [GO:0007411]; clustering of voltage-gated sodium channels [GO:0045162]; paranodal junction assembly [GO:0030913]; peripheral nervous system development [GO:0007422]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein targeting to plasma membrane [GO:0072661]; synapse organization [GO:0050808]; transmission of nerve impulse [GO:0019226] GO:0002175; GO:0005622; GO:0005886; GO:0005925; GO:0007411; GO:0007422; GO:0016021; GO:0019226; GO:0030424; GO:0030913; GO:0033010; GO:0033268; GO:0033270; GO:0043194; GO:0043209; GO:0045162; GO:0050808; GO:0070062; GO:0071205; GO:0072661; GO:0086080; GO:0097454 0 0 0 PF13882;PF00041;PF07679;PF00047; Q99M80 CHOYP_NEMVEDRAFT_V1G136229.1.2 m.21541 sp PTPRT_MOUSE 42.366 262 147 3 377 635 896 1156 4.85E-57 213 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9C056 CHOYP_NKX62.1.1 m.29693 sp NKX62_HUMAN 54.724 254 82 10 35 262 1 247 4.85E-75 233 NKX62_HUMAN reviewed Homeobox protein Nkx-6.2 (Homeobox protein NK-6 homolog B) NKX6-2 GTX NKX6B Homo sapiens (Human) 277 "central nervous system myelination [GO:0022010]; endocrine pancreas development [GO:0031018]; negative regulation of cell fate commitment [GO:0010454]; negative regulation of glial cell differentiation [GO:0045686]; neuromuscular process controlling balance [GO:0050885]; positive regulation of cell fate commitment [GO:0010455]; positive regulation of glial cell differentiation [GO:0045687]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification [GO:0021912]; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification [GO:0021913]" GO:0000978; GO:0001078; GO:0003700; GO:0005634; GO:0006355; GO:0010454; GO:0010455; GO:0021912; GO:0021913; GO:0022010; GO:0031018; GO:0045686; GO:0045687; GO:0050885 0 0 0 PF00046; Q9DEI1 CHOYP_LOC586799.1.1 m.18606 sp PRKDC_XENLA 37.135 377 230 4 4 377 22 394 4.85E-75 256 PRKDC_XENLA reviewed DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) prkdc Xenopus laevis (African clawed frog) 4146 double-strand break repair via nonhomologous end joining [GO:0006303]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431] GO:0003677; GO:0004677; GO:0005524; GO:0005730; GO:0006303; GO:0070419; GO:0072431 0 0 0 PF02259;PF02260;PF08163;PF00454; Q9SHU5 CHOYP_LOC100373889.1.4 m.9065 sp ARF4_ARATH 34.32 169 101 5 33 201 15 173 4.85E-19 84.3 ARF4_ARATH reviewed Probable ADP-ribosylation factor At2g15310 At2g15310 F27O10.4 Arabidopsis thaliana (Mouse-ear cress) 205 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q9VZW5 CHOYP_PHUM_PHUM268560.2.2 m.57114 sp FMAR_DROME 26.78 295 189 8 53 335 123 402 4.85E-20 94.7 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; A4IF63 CHOYP_TRIM2.40.59 m.42618 sp TRIM2_BOVIN 25.296 253 143 10 221 429 492 742 4.86E-08 58.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P02711 CHOYP_ACHA6.1.4 m.9624 sp ACHA_TORMA 29.24 342 224 9 8 341 11 342 4.86E-33 132 ACHA_TORMA reviewed Acetylcholine receptor subunit alpha CHRNA1 Torpedo marmorata (Marbled electric ray) 461 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; P0C872 CHOYP_LOC100888222.3.3 m.56624 sp JMJD7_MOUSE 29.897 291 166 9 229 514 36 293 4.86E-33 131 JMJD7_MOUSE reviewed JmjC domain-containing protein 7 (Jumonji domain-containing protein 7) Jmjd7 Mus musculus (Mouse) 316 0 0 0 0 0 0 P13952 CHOYP_CCNB.1.2 m.9736 sp CCNB_SPISO 75 108 27 0 4 111 318 425 4.86E-47 159 CCNB_SPISO reviewed G2/mitotic-specific cyclin-B 0 Spisula solidissima (Atlantic surf-clam) 428 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134; P40818 CHOYP_UBP4.1.2 m.26091 sp UBP8_HUMAN 26.71 307 180 13 347 621 778 1071 4.86E-14 79.3 UBP8_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) USP8 KIAA0055 UBPY Homo sapiens (Human) 1118 cell proliferation [GO:0008283]; endosome organization [GO:0007032]; ERBB2 signaling pathway [GO:0038128]; mitotic cytokinesis [GO:0000281]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000281; GO:0004197; GO:0004843; GO:0005654; GO:0005737; GO:0005769; GO:0005794; GO:0005829; GO:0005913; GO:0006511; GO:0007032; GO:0008283; GO:0016579; GO:0019897; GO:0030496; GO:0031313; GO:0038128; GO:0070536; GO:0071108; GO:0098641 0 0 0 PF00581;PF00443;PF08969; P81693 CHOYP_PPAC.1.1 m.31070 sp PPAC_PIG 48.026 152 72 4 37 185 8 155 4.86E-41 139 PPAC_PIG reviewed Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) ACP1 Sus scrofa (Pig) 158 0 GO:0003993; GO:0004726; GO:0005737; GO:0009898; GO:0070062 0 0 cd00115; PF01451; Q05974 CHOYP_RAB1A.1.3 m.10036 sp RAB1A_LYMST 92.233 206 14 2 1 205 1 205 4.86E-140 392 RAB1A_LYMST reviewed Ras-related protein Rab-1A RAB1A Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 205 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005783; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00071; Q07008 CHOYP_LOC100650248.1.1 m.2176 sp NOTC1_RAT 60.588 170 66 1 22 191 248 416 4.86E-65 219 NOTC1_RAT reviewed Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] Notch1 Rattus norvegicus (Rat) 2531 "aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; auditory receptor cell fate commitment [GO:0009912]; axonogenesis [GO:0007409]; brain development [GO:0007420]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac vascular smooth muscle cell development [GO:0060948]; cell differentiation in spinal cord [GO:0021515]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium morphogenesis [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart looping [GO:0001947]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; organ regeneration [GO:0031100]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral transcription [GO:0050434]; prostate gland epithelium morphogenesis [GO:0060740]; pulmonary valve morphogenesis [GO:0003184]; regulation of cardioblast proliferation [GO:0003264]; regulation of cell proliferation [GO:0042127]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; tissue regeneration [GO:0042246]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0001047; GO:0001190; GO:0001669; GO:0001701; GO:0001708; GO:0001726; GO:0001889; GO:0001947; GO:0002040; GO:0002052; GO:0002193; GO:0002437; GO:0003160; GO:0003162; GO:0003169; GO:0003180; GO:0003184; GO:0003192; GO:0003198; GO:0003213; GO:0003214; GO:0003219; GO:0003222; GO:0003241; GO:0003256; GO:0003264; GO:0003270; GO:0003273; GO:0003344; GO:0003700; GO:0004857; GO:0004872; GO:0005509; GO:0005634; GO:0005783; GO:0005794; GO:0005856; GO:0005886; GO:0005912; GO:0006959; GO:0007219; GO:0007221; GO:0007283; GO:0007386; GO:0007409; GO:0007420; GO:0007440; GO:0007492; GO:0008285; GO:0009912; GO:0009986; GO:0010718; GO:0010812; GO:0010832; GO:0014807; GO:0016021; GO:0016324; GO:0019899; GO:0021515; GO:0021915; GO:0030027; GO:0030216; GO:0030324; GO:0030335; GO:0030513; GO:0030514; GO:0030900; GO:0031069; GO:0031100; GO:0031490; GO:0031960; GO:0032495; GO:0032496; GO:0035116; GO:0035148; GO:0035914; GO:0035924; GO:0042127; GO:0042246; GO:0043065; GO:0043086; GO:0043235; GO:0043565; GO:0045070; GO:0045603; GO:0045608; GO:0045618; GO:0045662; GO:0045665; GO:0045668; GO:0045687; GO:0045747; GO:0045893; GO:0045944; GO:0045955; GO:0046427; GO:0046533; GO:0048103; GO:0048708; GO:0048709; GO:0048711; GO:0048715; GO:0048754; GO:0050434; GO:0050679; GO:0050768; GO:0060038; GO:0060045; GO:0060253; GO:0060271; GO:0060412; GO:0060528; GO:0060740; GO:0060768; GO:0060842; GO:0060843; GO:0060948; GO:0060956; GO:0060979; GO:0060982; GO:0061314; GO:0061419; GO:0070986; GO:0071372; GO:0072017; GO:0072044; GO:0072144; GO:0072602; GO:0090051; GO:0090090; GO:0097150; GO:1901201; GO:1902263; GO:2000737; GO:2000811; GO:2000974; GO:2001027 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; Q21735 CHOYP_NTF-2.1.1 m.38498 sp NTF2_CAEEL 41.667 132 75 2 32 162 2 132 4.86E-30 109 NTF2_CAEEL reviewed Probable nuclear transport factor 2 (NTF-2) ran-4 R05D11.3 Caenorhabditis elegans 133 protein transport [GO:0015031] GO:0005737; GO:0015031 0 0 cd00780; PF02136; Q28143 CHOYP_LOC100856796.1.3 m.4826 sp NRX3B_BOVIN 43.038 79 38 3 252 327 382 456 4.86E-10 63.9 NRX3B_BOVIN reviewed "Neurexin-3-beta (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)]" NRXN3 Bos taurus (Bovine) 456 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; neurotransmitter secretion [GO:0007269]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; synapse assembly [GO:0007416] GO:0001525; GO:0005576; GO:0005886; GO:0007155; GO:0007269; GO:0007416; GO:0016021; GO:0051965; GO:0090129; GO:0098793 0 0 0 PF02210;PF01034; Q571C7 CHOYP_BDP1.1.2 m.27406 sp BDP1_MOUSE 35.683 227 134 3 206 427 178 397 4.86E-34 144 BDP1_MOUSE reviewed Transcription factor TFIIIB component B'' homolog (Transcription factor IIIB 150) (TFIIIB150) (Transcription factor-like nuclear regulator) Bdp1 Kiaa1241 Tfnr Mus musculus (Mouse) 2467 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000126; GO:0001026; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006355 0 0 0 0 Q5U4T9 CHOYP_LOC100374966.1.1 m.40456 sp MBOA7_XENLA 42.217 469 265 6 15 480 4 469 4.86E-120 362 MBOA7_XENLA reviewed Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (Leukocyte receptor cluster member 4) (Membrane-bound O-acyltransferase domain-containing protein 7) (O-acyltransferase domain-containing protein 7) mboat7 leng4 oact7 Xenopus laevis (African clawed frog) 474 phospholipid biosynthetic process [GO:0008654] GO:0008654; GO:0016021; GO:0016746 PATHWAY: Lipid metabolism; phospholipid metabolism. 0 0 PF03062; Q5ZI40 CHOYP_GTDC1.1.1 m.15237 sp GTDC1_CHICK 43.377 385 158 9 12 392 4 332 4.86E-91 286 GTDC1_CHICK reviewed Glycosyltransferase-like domain-containing protein 1 GTDC1 RCJMB04_30i19 Gallus gallus (Chicken) 382 0 GO:0016757 0 0 0 PF12038; Q62261 CHOYP_BRAFLDRAFT_93030.1.1 m.29276 sp SPTB2_MOUSE 31.931 927 623 6 7 930 1154 2075 4.86E-138 474 SPTB2_MOUSE reviewed "Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain)" Sptbn1 Elf Spnb-2 Spnb2 Sptb2 Mus musculus (Mouse) 2363 actin filament capping [GO:0051693]; common-partner SMAD protein phosphorylation [GO:0007182]; Golgi to plasma membrane protein transport [GO:0043001]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 secretion [GO:1900042]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein targeting to plasma membrane [GO:0072661]; regulation of protein localization to plasma membrane [GO:1903076]; SMAD protein import into nucleus [GO:0007184] GO:0000281; GO:0005200; GO:0005543; GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0007009; GO:0007182; GO:0007184; GO:0008091; GO:0012505; GO:0014069; GO:0016020; GO:0030506; GO:0030673; GO:0030863; GO:0031430; GO:0032437; GO:0043001; GO:0044822; GO:0051020; GO:0051693; GO:0070062; GO:0071709; GO:0072661; GO:1900042; GO:1903076; GO:1903078 0 0 0 PF00307;PF00435; Q66HG4 CHOYP_contig_023445 m.26685 sp GALM_RAT 42.486 346 185 8 13 357 9 341 4.86E-82 256 GALM_RAT reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) Galm Rattus norvegicus (Rat) 342 galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006] GO:0004034; GO:0005737; GO:0006006; GO:0006012; GO:0030246; GO:0070062 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; Q6PIP5 CHOYP_LOC590657.1.1 m.634 sp NUDC1_MOUSE 38.786 593 327 15 13 590 8 579 4.86E-139 419 NUDC1_MOUSE reviewed NudC domain-containing protein 1 Nudcd1 Mus musculus (Mouse) 582 0 GO:0005634; GO:0005737 0 0 0 PF04969; Q7Z7G8 CHOYP_BRAFLDRAFT_75094.2.2 m.64333 sp VP13B_HUMAN 27.712 848 547 20 16 840 2455 3259 4.86E-83 300 VP13B_HUMAN reviewed Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1) VPS13B CHS1 COH1 KIAA0532 Homo sapiens (Human) 4022 protein transport [GO:0015031] GO:0015031 0 0 0 PF12624;PF06650;PF16909; Q80T91 CHOYP_PTPRC.8.14 m.42348 sp MEG11_MOUSE 37.344 241 138 9 135 375 205 432 4.86E-31 131 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8WRF3 CHOYP_BRAFLDRAFT_114866.1.5 m.6860 sp RL32_APIME 81.513 119 22 0 23 141 1 119 4.86E-67 202 RL32_APIME reviewed 60S ribosomal protein L32 (Ribosomal protein 49) RpL32 rp49 Apis mellifera (Honeybee) 134 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00513; PF01655; Q92197 CHOYP_DSEC_GM10642.1.1 m.47741 sp CHSC_ASPFU 24.877 406 235 14 803 1139 352 756 4.86E-19 97.8 CHSC_ASPFU reviewed Chitin synthase C (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase C) (Class-III chitin synthase C) chsC AFUA_5G00760 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) 893 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0071555 0 0 0 PF01644;PF08407; Q9BRZ2 CHOYP_TRI18.4.6 m.35892 sp TRI56_HUMAN 24.823 282 173 8 18 279 16 278 4.86E-16 83.6 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9NZC7 CHOYP_LOC763133.2.3 m.44158 sp WWOX_HUMAN 35.738 305 170 7 16 314 125 409 4.86E-53 182 WWOX_HUMAN reviewed WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1) WWOX FOR SDR41C1 WOX1 Homo sapiens (Human) 414 cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; oxidation-reduction process [GO:0055114]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; skeletal system morphogenesis [GO:0048705]; steroid metabolic process [GO:0008202]; Wnt signaling pathway [GO:0016055] GO:0001105; GO:0001649; GO:0005634; GO:0005737; GO:0005739; GO:0005794; GO:0005829; GO:0008202; GO:0016055; GO:0016491; GO:0019899; GO:0030178; GO:0045944; GO:0046983; GO:0048037; GO:0048705; GO:0050662; GO:0055114; GO:0071560; GO:0072332; GO:0090575; GO:0097191; GO:2001238; GO:2001241 0 0 0 PF00106;PF00397; Q9WV76 CHOYP_LOC100495149.1.1 m.16673 sp AP4B1_MOUSE 32.849 344 228 1 8 351 119 459 4.86E-61 211 AP4B1_MOUSE reviewed AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin) Ap4b1 Mus musculus (Mouse) 738 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005802; GO:0005905; GO:0006886; GO:0008565; GO:0016192; GO:0030131 0 0 0 PF01602;PF09066; A2VE79 CHOYP_LOC656747.1.1 m.53714 sp NUDT3_BOVIN 60 145 57 1 1 144 1 145 4.87E-63 193 NUDT3_BOVIN reviewed "Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3)" NUDT3 DIPP1 Bos taurus (Bovine) 172 diphosphoinositol polyphosphate catabolic process [GO:0071544] GO:0000287; GO:0005737; GO:0008486; GO:0052840; GO:0052843; GO:0052844; GO:0052845; GO:0052846; GO:0052847; GO:0052848; GO:0070062; GO:0071544 0 0 0 PF00293; A4IF78 CHOYP_LOC100369290.1.1 m.66929 sp TFIP8_BOVIN 50.273 183 91 0 25 207 16 198 4.87E-65 202 TFIP8_BOVIN reviewed Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) TNFAIP8 Bos taurus (Bovine) 198 0 GO:0005737; GO:0043027 0 0 0 PF05527; P09208 CHOYP_DVIR_GJ23604.1.1 m.57015 sp INSR_DROME 26.131 199 113 5 180 375 1484 1651 4.87E-15 83.2 INSR_DROME reviewed Insulin-like receptor (dIR) (dInr) (EC 2.7.10.1) (dIRH) [Cleaved into: Insulin-like receptor subunit alpha; Insulin-like receptor subunit beta 1; Insulin-like receptor subunit beta 2] InR dinr Dir-a Inr-a CG18402 Drosophila melanogaster (Fruit fly) 2144 "aging [GO:0007568]; axon guidance [GO:0007411]; carbohydrate metabolic process [GO:0005975]; cell growth [GO:0016049]; cellular response to DNA damage stimulus [GO:0006974]; circadian rhythm [GO:0007623]; determination of adult lifespan [GO:0008340]; developmental growth [GO:0048589]; dorsal closure [GO:0007391]; embryo development [GO:0009790]; embryonic development via the syncytial blastoderm [GO:0001700]; female germ-line stem cell asymmetric division [GO:0048132]; female gonad development [GO:0008585]; female mating behavior [GO:0060180]; germ-band shortening [GO:0007390]; germ-line stem-cell niche homeostasis [GO:0060250]; growth [GO:0040007]; imaginal disc growth [GO:0007446]; insulin receptor signaling pathway [GO:0008286]; intestinal stem cell homeostasis [GO:0036335]; lipid metabolic process [GO:0006629]; locomotory behavior [GO:0007626]; male germ-line stem cell asymmetric division [GO:0048133]; multicellular organism growth [GO:0035264]; myoblast fusion [GO:0007520]; negative regulation of autophagy [GO:0010507]; negative regulation of circadian sleep/wake cycle, sleep [GO:0042321]; negative regulation of feeding behavior [GO:2000252]; negative regulation of peptide hormone secretion [GO:0090278]; nervous system development [GO:0007399]; neuron remodeling [GO:0016322]; ovarian follicle cell development [GO:0030707]; positive regulation of cell growth [GO:0030307]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cell size [GO:0045793]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of organ growth [GO:0046622]; primary spermatocyte growth [GO:0007285]; protein autophosphorylation [GO:0046777]; protein heterotetramerization [GO:0051290]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; regulation of cell size [GO:0008361]; regulation of glucose metabolic process [GO:0010906]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to anoxia [GO:0034059]; response to cocaine [GO:0042220]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979]; somatic muscle development [GO:0007525]; trachea morphogenesis [GO:0060439]; vitellogenesis [GO:0007296]" GO:0001700; GO:0004713; GO:0005009; GO:0005524; GO:0005886; GO:0005899; GO:0005911; GO:0005975; GO:0006468; GO:0006629; GO:0006974; GO:0006979; GO:0007285; GO:0007296; GO:0007390; GO:0007391; GO:0007399; GO:0007411; GO:0007446; GO:0007520; GO:0007525; GO:0007568; GO:0007584; GO:0007623; GO:0007626; GO:0008284; GO:0008286; GO:0008340; GO:0008361; GO:0008585; GO:0009790; GO:0010507; GO:0010906; GO:0016049; GO:0016322; GO:0030307; GO:0030707; GO:0034059; GO:0035264; GO:0036335; GO:0040007; GO:0040014; GO:0040018; GO:0042127; GO:0042220; GO:0042321; GO:0042802; GO:0043548; GO:0043559; GO:0043560; GO:0045793; GO:0046620; GO:0046622; GO:0046777; GO:0046872; GO:0048132; GO:0048133; GO:0048589; GO:0051290; GO:0060180; GO:0060250; GO:0060439; GO:0090278; GO:2000252; GO:2000377 0 0 0 PF00757;PF07714;PF01030; P40855 CHOYP_PEX2.2.2 m.26981 sp PEX19_HUMAN 37.132 272 152 5 20 272 12 283 4.87E-52 175 PEX19_HUMAN reviewed Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein) PEX19 HK33 PXF OK/SW-cl.22 Homo sapiens (Human) 299 chaperone-mediated protein folding [GO:0061077]; chaperone-mediated protein transport [GO:0072321]; establishment of protein localization to peroxisome [GO:0072663]; negative regulation of lipid binding [GO:1900131]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; protein import into peroxisome membrane [GO:0045046]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]; transmembrane transport [GO:0055085] GO:0005634; GO:0005654; GO:0005737; GO:0005777; GO:0005778; GO:0005829; GO:0006625; GO:0007031; GO:0016021; GO:0016557; GO:0016559; GO:0031526; GO:0036105; GO:0043231; GO:0043234; GO:0045046; GO:0047485; GO:0050821; GO:0051117; GO:0055085; GO:0061077; GO:0072321; GO:0072663; GO:1900131 0 0 0 PF04614; P50538 CHOYP_PEX5.1.2 m.44603 sp MAD1_MOUSE 46.262 214 82 6 1 187 1 208 4.87E-44 149 MAD1_MOUSE reviewed Max dimerization protein 1 (Max dimerizer 1) (Protein MAD) Mxd1 Mad Mad1 Mus musculus (Mouse) 227 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0000978; GO:0001078; GO:0006351 0 0 0 PF00010; P56974 CHOYP_LOC101164582.1.2 m.52405 sp NRG2_MOUSE 27.989 368 208 14 12 353 8 344 4.87E-31 132 NRG2_MOUSE reviewed "Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)]" Nrg2 Mus musculus (Mouse) 756 animal organ development [GO:0048513]; intracellular signal transduction [GO:0035556] GO:0005102; GO:0005615; GO:0005622; GO:0005886; GO:0016021; GO:0035556; GO:0048513 0 0 0 PF07679;PF02158; P91778 CHOYP_LOC587610.2.3 m.26698 sp AMY_PECMA 52.13 493 213 10 17 489 13 502 4.87E-162 480 AMY_PECMA reviewed "Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)" 0 Pecten maximus (King scallop) (Pilgrim's clam) 508 carbohydrate metabolic process [GO:0005975] GO:0004556; GO:0005975; GO:0046872 0 0 0 PF00128;PF02806; P97376 CHOYP_LOC100123667.1.1 m.22353 sp FRG1_MOUSE 53.008 266 109 4 29 289 4 258 4.87E-80 245 FRG1_MOUSE reviewed Protein FRG1 (FSHD region gene 1 protein) Frg1 Mus musculus (Mouse) 258 mRNA processing [GO:0006397]; muscle organ development [GO:0007517]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364] GO:0005730; GO:0006364; GO:0006397; GO:0007517; GO:0008380; GO:0015030; GO:0030018; GO:0044822; GO:0051015; GO:0055120; GO:0071013 0 0 0 PF06229; Q14162 CHOYP_MEGF11.7.11 m.52029 sp SREC_HUMAN 29.223 373 167 18 172 485 53 387 4.87E-19 95.1 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q24799 CHOYP_LOC100748165.1.1 m.44439 sp MYPH_ECHGR 41.489 188 97 3 648 827 8 190 4.87E-35 135 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q32L63 CHOYP_LOC100378584.3.3 m.63220 sp VTA1_BOVIN 40.957 188 73 7 7 177 140 306 4.87E-29 112 VTA1_BOVIN reviewed Vacuolar protein sorting-associated protein VTA1 homolog VTA1 Bos taurus (Bovine) 307 protein transport [GO:0015031] GO:0010008; GO:0015031 0 0 0 0 Q3UUQ7 CHOYP_LOC100561975.1.1 m.51262 sp PGAP1_MOUSE 26.741 359 223 9 10 332 512 866 4.87E-26 114 PGAP1_MOUSE reviewed GPI inositol-deacylase (EC 3.1.-.-) (Post-GPI attachment to proteins factor 1) Pgap1 Mus musculus (Mouse) 922 anterior/posterior axis specification [GO:0009948]; embryonic pattern specification [GO:0009880]; forebrain regionalization [GO:0021871]; GPI anchor biosynthetic process [GO:0006506]; head development [GO:0060322]; myo-inositol transport [GO:0015798]; protein transport [GO:0015031]; sensory perception of sound [GO:0007605] GO:0004518; GO:0005783; GO:0005789; GO:0006506; GO:0007605; GO:0009880; GO:0009948; GO:0015031; GO:0015798; GO:0016021; GO:0021871; GO:0042578; GO:0060322 0 0 0 PF07819; Q562D6 CHOYP_NAP1.1.1 m.1308 sp TRMO_MOUSE 39.785 372 174 6 5 328 27 396 4.87E-76 242 TRMO_MOUSE reviewed tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O) Trmo Mus musculus (Mouse) 431 tRNA methylation [GO:0030488] GO:0003723; GO:0016430; GO:0030488 0 0 cd09281; PF01980; Q59LU0 CHOYP_DBP2.2.2 m.55820 sp DBP2_CANAL 47.523 444 222 8 91 533 86 519 4.87E-129 394 DBP2_CANAL reviewed ATP-dependent RNA helicase DBP2 (EC 3.6.4.13) DBP2 CaO19.171 CaO19.7804 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) 562 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]" GO:0000184; GO:0003723; GO:0004386; GO:0005524; GO:0005634; GO:0005737; GO:0006364 0 0 0 PF00270;PF00271; Q6AXS5 CHOYP_LOC100727208.1.1 m.9366 sp PAIRB_RAT 33.628 339 163 10 5 292 9 336 4.87E-26 111 PAIRB_RAT reviewed "Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (RDA288) (SERPINE1 mRNA-binding protein 1) [Cleaved into: Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processed]" Serbp1 Pairbp1 Rda288 Rattus norvegicus (Rat) 407 regulation of apoptotic process [GO:0042981] GO:0003730; GO:0005634; GO:0005737; GO:0005886; GO:0042981; GO:0048471; GO:0070062 0 0 0 PF04774;PF16174; Q6R7J0 CHOYP_Y028.1.1 m.30885 sp Y034_OSHVF 100 124 0 0 14 137 1 124 4.87E-89 257 Y034_OSHVF reviewed Uncharacterized protein ORF34 ORF34 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 124 0 0 0 0 0 0 Q91WJ8 CHOYP_BRAFLDRAFT_124476.3.4 m.48505 sp FUBP1_MOUSE 48.148 81 21 5 32 102 26 95 4.87E-06 47.4 FUBP1_MOUSE reviewed Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) Fubp1 D3Ertd330e Mus musculus (Mouse) 651 cell growth [GO:0016049]; hematopoietic stem cell proliferation [GO:0071425]; positive regulation of gene expression [GO:0010628]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; stem cell division [GO:0017145] GO:0001205; GO:0003677; GO:0005634; GO:0005654; GO:0006357; GO:0010628; GO:0016049; GO:0017145; GO:0044822; GO:0071425 0 0 0 PF09005;PF00013; Q92624 CHOYP_APPBP2.1.1 m.9093 sp APBP2_HUMAN 25.245 408 291 8 263 664 57 456 4.87E-22 104 APBP2_HUMAN reviewed Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1) APPBP2 KIAA0228 PAT1 Homo sapiens (Human) 585 intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907] GO:0003777; GO:0005634; GO:0005737; GO:0005874; GO:0005875; GO:0006886; GO:0030659; GO:0046907 0 0 0 PF13374; Q9UDY4 CHOYP_LOC752244.2.2 m.45622 sp DNJB4_HUMAN 56.667 360 127 3 1 354 1 337 4.87E-132 383 DNJB4_HUMAN reviewed DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) DNAJB4 DNAJW HLJ1 Homo sapiens (Human) 337 protein folding [GO:0006457]; response to heat [GO:0009408]; response to unfolded protein [GO:0006986] GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0006457; GO:0006986; GO:0009408; GO:0051082; GO:0051087; GO:0070062 0 0 cd06257; PF00226;PF01556; A6H603 CHOYP_TRIADDRAFT_19804.1.1 m.8993 sp NWD1_MOUSE 27.5 360 220 10 103 457 1 324 4.88E-36 145 NWD1_MOUSE reviewed NACHT domain- and WD repeat-containing protein 1 Nwd1 Mus musculus (Mouse) 1563 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; O60290 CHOYP_LOC101445267.1.1 m.15195 sp ZN862_HUMAN 23.881 134 89 3 47 179 494 615 4.88E-06 49.3 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; O95948 CHOYP_ONEC2.3.3 m.53779 sp ONEC2_HUMAN 46.12 451 131 14 73 478 105 488 4.88E-103 320 ONEC2_HUMAN reviewed One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) ONECUT2 HNF6B Homo sapiens (Human) 504 cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cilium assembly [GO:0042384]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; organ morphogenesis [GO:0009887]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell migration [GO:0030335]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952] GO:0000978; GO:0001077; GO:0001889; GO:0001952; GO:0002064; GO:0005634; GO:0005654; GO:0009887; GO:0015629; GO:0030154; GO:0030335; GO:0030512; GO:0031018; GO:0042384; GO:0045165; GO:0045944; GO:0048935 0 0 0 PF02376;PF00046; P07207 CHOYP_NOTC1.3.4 m.13266 sp NOTCH_DROME 35.214 514 306 21 135 636 720 1218 4.88E-64 236 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P25007 CHOYP_PHATRDRAFT_43152.1.1 m.15003 sp PPIA_DROME 65.556 180 59 2 26 205 51 227 4.88E-82 246 PPIA_DROME reviewed Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) Cyp1 Cyp-1 CG9916 Drosophila melanogaster (Fruit fly) 227 autophagic cell death [GO:0048102]; protein folding [GO:0006457]; salivary gland cell autophagic cell death [GO:0035071] GO:0003755; GO:0005634; GO:0005737; GO:0005829; GO:0005875; GO:0006457; GO:0035071; GO:0042277; GO:0048102 0 0 0 PF00160; P47911 CHOYP_BRAFLDRAFT_114734.1.8 m.7203 sp RL6_MOUSE 65.753 73 24 1 30 101 100 172 4.88E-24 95.5 RL6_MOUSE reviewed 60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) Rpl6 Mus musculus (Mouse) 296 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; Q0WU02 CHOYP_BM1_24985.1.1 m.51243 sp MTP10_ARATH 39.368 348 187 6 117 456 95 426 4.88E-75 244 MTP10_ARATH reviewed Metal tolerance protein 10 (AtMTP10) MTP10 At1g16310 F3O9.11 Arabidopsis thaliana (Mouse-ear cress) 428 regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043] GO:0005385; GO:0005774; GO:0010043; GO:0016020; GO:0016021; GO:0061088 0 0 0 PF01545;PF16916; Q28298 CHOYP_LOC100369294.3.6 m.24633 sp RRBP1_CANLF 25.966 828 472 28 217 989 785 1526 4.88E-21 103 RRBP1_CANLF reviewed Ribosome-binding protein 1 (180 kDa ribosome receptor) (RRp) RRBP1 P180 Canis lupus familiaris (Dog) (Canis familiaris) 1534 protein transport [GO:0015031]; signal transduction [GO:0007165]; translation [GO:0006412] GO:0004872; GO:0005840; GO:0006412; GO:0007165; GO:0015031; GO:0030176 0 0 0 PF05104; Q2KI83 CHOYP_DJC17.1.1 m.33348 sp DJC17_BOVIN 44.737 152 65 3 2 153 169 301 4.88E-30 113 DJC17_BOVIN reviewed DnaJ homolog subfamily C member 17 DNAJC17 Bos taurus (Bovine) 304 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; toxin transport [GO:1901998]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006351; GO:1901998 0 0 cd06257; PF00226;PF00076; Q5BIM1 CHOYP_ZF_BBOX_RING_-1.6.10 m.41229 sp TRI45_BOVIN 23 300 190 11 18 289 29 315 4.88E-11 66.6 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5BJ29 CHOYP_LOC100893988.1.1 m.35031 sp FBXL7_MOUSE 27.358 318 201 8 201 516 199 488 4.88E-20 96.7 FBXL7_MOUSE reviewed F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) Fbxl7 Kiaa0840 Mus musculus (Mouse) 491 cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000086; GO:0005737; GO:0005813; GO:0007067; GO:0008283; GO:0016567; GO:0019005; GO:0031146; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q5SPB6 CHOYP_CG10365.1.1 m.15506 sp CHAC1_DANRE 40.223 179 97 4 25 201 15 185 4.88E-40 139 CHAC1_DANRE reviewed Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 2.3.2.-) (Cation transport regulator-like protein 1) chac1 Danio rerio (Zebrafish) (Brachydanio rerio) 196 apoptotic process [GO:0006915]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein processing [GO:0010955]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; response to unfolded protein [GO:0006986] GO:0005112; GO:0005802; GO:0005829; GO:0006915; GO:0006986; GO:0007219; GO:0010955; GO:0016746; GO:0022008; GO:0045746 0 0 cd06661; PF04752; Q6MHJ5 CHOYP_LOC100379079.1.5 m.10047 sp PIF1_BDEBA 46.377 69 34 1 107 175 365 430 4.88E-10 63.5 PIF1_BDEBA reviewed ATP-dependent DNA helicase pif1 (EC 3.6.4.12) pif1 Bd3546 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) 439 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] GO:0000723; GO:0003677; GO:0003678; GO:0005524; GO:0006281; GO:0006310 0 0 0 PF05970; Q80TL4 CHOYP_LOC100369901.1.2 m.9587 sp PHF24_MOUSE 27.82 266 168 7 88 334 130 390 4.88E-24 104 PHF24_MOUSE reviewed PHD finger protein 24 Phf24 Kiaa1045 N28178 Mus musculus (Mouse) 400 0 GO:0005509 0 0 0 PF16744; Q8MQJ9 CHOYP_BRAFLDRAFT_99993.3.4 m.20467 sp BRAT_DROME 21.86 215 130 8 95 293 783 975 4.88E-07 54.7 BRAT_DROME reviewed Brain tumor protein brat CG10719 Drosophila melanogaster (Fruit fly) 1037 asymmetric cell division [GO:0008356]; asymmetric neuroblast division resulting in ganglion mother cell formation [GO:0055060]; axon guidance [GO:0007411]; brain development [GO:0007420]; ganglion mother cell fate determination [GO:0007402]; negative regulation of cell proliferation [GO:0008285]; negative regulation of neuroblast proliferation [GO:0007406]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; oogenesis [GO:0048477]; phagocytosis [GO:0006909]; regulation of neurogenesis [GO:0050767]; regulation of synaptic growth at neuromuscular junction [GO:0008582]; regulation of synaptic vesicle endocytosis [GO:1900242]; regulation of translation [GO:0006417]; rRNA transcription [GO:0009303]; segmentation [GO:0035282]; ventral cord development [GO:0007419] GO:0005737; GO:0006417; GO:0006909; GO:0007400; GO:0007402; GO:0007405; GO:0007406; GO:0007411; GO:0007419; GO:0007420; GO:0008270; GO:0008285; GO:0008356; GO:0008582; GO:0009303; GO:0022008; GO:0030182; GO:0030371; GO:0035282; GO:0043025; GO:0045182; GO:0048477; GO:0050767; GO:0055060; GO:1900242 0 0 0 PF01436;PF00643; Q9CZJ2 CHOYP_BRAFLDRAFT_240123.4.6 m.39151 sp HS12B_MOUSE 34.211 532 286 13 1 473 61 587 4.88E-84 276 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9VVE5 CHOYP_RBP6.2.2 m.41144 sp MSIR6_DROME 57.492 327 86 7 19 294 23 347 4.88E-116 343 MSIR6_DROME reviewed RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) 369 stem cell development [GO:0048864] GO:0000166; GO:0003727; GO:0005737; GO:0005844; GO:0008266; GO:0048864 0 0 0 PF00076; A2AJ76 CHOYP_CD22.2.4 m.50790 sp HMCN2_MOUSE 22.462 325 206 13 61 353 2524 2834 4.89E-11 68.2 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A6NCS4 CHOYP_NKX23.1.1 m.25439 sp NKX26_HUMAN 69.531 128 36 2 169 294 114 240 4.89E-49 169 NKX26_HUMAN reviewed Homeobox protein Nkx-2.6 (Homeobox protein NK-2 homolog F) NKX2-6 NKX2F Homo sapiens (Human) 301 "atrial cardiac muscle cell development [GO:0055014]; cell differentiation [GO:0030154]; digestive tract development [GO:0048565]; embryonic heart tube development [GO:0035050]; hypothalamus development [GO:0021854]; negative regulation of apoptotic process [GO:0043066]; pericardium development [GO:0060039]; pharyngeal system development [GO:0060037]; positive regulation of cell proliferation [GO:0008284]; tongue development [GO:0043586]; transcription, DNA-templated [GO:0006351]; ventricular cardiac muscle cell development [GO:0055015]" GO:0003700; GO:0005634; GO:0006351; GO:0008284; GO:0021854; GO:0030154; GO:0035050; GO:0043066; GO:0043565; GO:0043586; GO:0048565; GO:0055014; GO:0055015; GO:0060037; GO:0060039 0 0 0 PF00046; F1LZF0 CHOYP_LOC100908565.1.1 m.45407 sp KLHL2_RAT 22 150 108 3 125 274 14 154 4.89E-06 51.2 KLHL2_RAT reviewed Kelch-like protein 2 (Mayven) Klhl2 Rattus norvegicus (Rat) 593 protein ubiquitination [GO:0016567] GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0031463 0 0 0 PF07707;PF00651;PF01344; O57429 CHOYP_LOC100186834.1.2 m.55935 sp UBP2_CHICK 26 350 197 11 785 1092 20 349 4.89E-19 93.6 UBP2_CHICK reviewed Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Gallus gallus (Chicken) 357 protein deubiquitination [GO:0016579]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0016579; GO:0046872; GO:0048471; GO:0048511 0 0 0 PF00443; O60271 CHOYP_BRAFLDRAFT_117085.1.1 m.38253 sp JIP4_HUMAN 54.286 105 48 0 20 124 609 713 4.89E-35 130 JIP4_HUMAN reviewed C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) SPAG9 HSS KIAA0516 MAPK8IP4 SYD1 HLC6 Homo sapiens (Human) 1321 "activation of JUN kinase activity [GO:0007257]; negative regulation of protein homodimerization activity [GO:0090074]; positive regulation of cell migration [GO:0030335]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron differentiation [GO:0045666]; protein homooligomerization [GO:0051260]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; striated muscle cell differentiation [GO:0051146]" GO:0001669; GO:0005078; GO:0005737; GO:0005815; GO:0005829; GO:0007257; GO:0007283; GO:0008432; GO:0016021; GO:0019894; GO:0030159; GO:0030335; GO:0042147; GO:0045666; GO:0048471; GO:0051146; GO:0051149; GO:0051260; GO:0070062; GO:0090074 0 0 0 PF16471;PF09744; P04113 CHOYP_MLRA.3.3 m.62296 sp MLRA_MIZYE 80.503 159 31 0 8 166 3 161 4.89E-88 257 MLRA_MIZYE reviewed "Myosin regulatory light chain A, smooth adductor muscle" 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 161 0 GO:0005509; GO:0016459 0 0 0 PF13405; P10079 CHOYP_LOC100634060.1.37 m.2547 sp FBP1_STRPU 49.725 364 145 1 2 327 185 548 4.89E-104 330 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10394 CHOYP_LOC100894010.2.6 m.7851 sp POL4_DROME 28.88 1250 745 35 341 1520 61 1236 4.89E-136 457 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P13944 CHOYP_LOC100030437.3.3 m.42706 sp COCA1_CHICK 24.486 486 322 10 81 529 139 616 4.89E-36 148 COCA1_CHICK reviewed Collagen alpha-1(XII) chain (Fibrochimerin) COL12A1 Gallus gallus (Chicken) 3124 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00041;PF00092; Q4ZJM9 CHOYP_LOC101159074.1.1 m.29872 sp C1QL4_MOUSE 30.216 139 79 5 89 219 110 238 4.89E-09 58.2 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q6PBD7 CHOYP_SMRC2.1.2 m.19461 sp ID2_XENTR 44.762 105 47 5 1 96 1 103 4.89E-18 77 ID2_XENTR reviewed DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2) id2 TTpA010o03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 132 "cellular senescence [GO:0090398]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal digestive tract morphogenesis [GO:0061031]; negative regulation of gene expression [GO:0010629]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron fate commitment [GO:0048663]; positive regulation of blood pressure [GO:0045777]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of gene expression [GO:0010628]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0005737; GO:0006351; GO:0010628; GO:0010629; GO:0042752; GO:0043234; GO:0043425; GO:0045665; GO:0045777; GO:0045892; GO:0045893; GO:0048511; GO:0048557; GO:0048661; GO:0048663; GO:0061031; GO:0071158; GO:0090398; GO:2000178 0 0 0 PF00010; Q6PIJ6 CHOYP_LOC426699.1.1 m.17009 sp FBX38_HUMAN 48.712 466 238 1 27 492 25 489 4.89E-155 500 FBX38_HUMAN reviewed F-box only protein 38 (Modulator of KLF7 activity homolog) (MoKA) FBXO38 SP329 Homo sapiens (Human) 1188 positive regulation of neuron projection development [GO:0010976] GO:0005634; GO:0005737; GO:0010976 0 0 0 PF00646; Q700K0 CHOYP_LOC100210677.8.8 m.43132 sp SSPO_RAT 26.87 2259 1189 74 539 2417 2484 4659 4.89E-130 464 SSPO_RAT reviewed SCO-spondin Sspo Rattus norvegicus (Rat) 5141 cell adhesion [GO:0007155] GO:0005615; GO:0007155 0 0 0 PF08742;PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q7RTV5 CHOYP_C9ORF21.1.1 m.8358 sp AAED1_HUMAN 44.388 196 106 2 38 231 32 226 4.89E-57 183 AAED1_HUMAN reviewed Thioredoxin-like protein AAED1 (AhpC/TSA antioxidant enzyme domain-containing protein 1) AAED1 C9orf21 Homo sapiens (Human) 226 oxidation-reduction process [GO:0055114] GO:0016209; GO:0055114 0 0 0 PF13911; Q8N7M0 CHOYP_TC1D1.1.1 m.59653 sp TC1D1_HUMAN 32.759 174 102 3 55 214 7 179 4.89E-21 89 TC1D1_HUMAN reviewed Tctex1 domain-containing protein 1 TCTEX1D1 Homo sapiens (Human) 179 0 0 0 0 0 PF03645; Q8R3W5 CHOYP_LOC100892594.1.1 m.10575 sp SEN15_MOUSE 30.952 126 84 1 28 150 40 165 4.89E-12 64.7 SEN15_MOUSE reviewed tRNA-splicing endonuclease subunit Sen15 (tRNA-intron endonuclease Sen15) Tsen15 Sen15 Mus musculus (Mouse) 168 "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000213; GO:0005730; GO:0006388; GO:0006397 0 0 0 PF09631; Q9C0G0 CHOYP_ZN407.1.1 m.59120 sp ZN407_HUMAN 32.444 487 285 13 809 1270 1414 1881 4.89E-65 247 ZN407_HUMAN reviewed Zinc finger protein 407 ZNF407 KIAA1703 Homo sapiens (Human) 2248 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 0 Q9CQ90 CHOYP_LOC100650709.1.1 m.12958 sp CI085_MOUSE 53.774 106 49 0 1 106 1 106 4.89E-36 126 CI085_MOUSE reviewed Uncharacterized protein C9orf85 homolog 0 Mus musculus (Mouse) 155 0 0 0 0 0 PF10217; Q9EPA7 CHOYP_LOC577778.1.1 m.57642 sp NMNA1_MOUSE 54.135 266 108 3 27 289 4 258 4.89E-93 282 NMNA1_MOUSE reviewed Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMN/NaMN adenylyltransferase 1) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 1) (NMN adenylyltransferase 1) (Nicotinate-nucleotide adenylyltransferase 1) (NaMN adenylyltransferase 1) Nmnat1 D4Cole1e Nmnat Mus musculus (Mouse) 285 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; ATP generation from poly-ADP-D-ribose [GO:1990966]; NAD biosynthetic process [GO:0009435]; response to wounding [GO:0009611] GO:0000309; GO:0004515; GO:0005524; GO:0005634; GO:0009435; GO:0009611; GO:0034628; GO:1990966 PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. 0 0 PF01467; A2AX52 CHOYP_MATN1.2.5 m.45361 sp CO6A4_MOUSE 31.436 369 240 8 18 379 53 415 4.90E-45 186 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; B3EWZ3 CHOYP_LOC101236385.4.6 m.22188 sp CADN_ACRMI 45.263 190 97 3 153 341 223 406 4.90E-47 179 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; O01369 CHOYP_UCCR.1.2 m.129 sp QCR7_FASHE 39.175 97 59 0 53 149 25 121 4.90E-19 80.5 QCR7_FASHE reviewed Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) UBCRBP Fasciola hepatica (Liver fluke) 130 "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" GO:0005750; GO:0006122 0 0 0 PF02271; O57472 CHOYP_CHRD.1.2 m.10328 sp CHRD_DANRE 29.385 667 402 17 1 625 276 915 4.90E-90 302 CHRD_DANRE reviewed Chordin (Protein chordino) chd chrd Danio rerio (Zebrafish) (Brachydanio rerio) 940 anterior/posterior axis specification [GO:0009948]; caudal fin morphogenesis [GO:0035143]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; dorsal convergence [GO:0060030]; embryonic heart tube morphogenesis [GO:0003143]; embryonic hemopoiesis [GO:0035162]; heart looping [GO:0001947]; Kupffer's vesicle development [GO:0070121]; negative regulation of BMP signaling pathway [GO:0030514]; otic placode formation [GO:0043049]; regulation of BMP signaling pathway involved in heart jogging [GO:2000223]; somitogenesis [GO:0001756]; specification of organ position [GO:0010159] GO:0001756; GO:0001947; GO:0003143; GO:0005576; GO:0007368; GO:0009948; GO:0009953; GO:0010159; GO:0030514; GO:0035143; GO:0035162; GO:0043049; GO:0048264; GO:0060030; GO:0061371; GO:0070121; GO:2000223 0 0 0 PF07452;PF00093; O75382 CHOYP_BRAFLDRAFT_69765.21.23 m.60875 sp TRIM3_HUMAN 24.016 254 177 7 200 438 492 744 4.90E-12 71.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O96790 CHOYP_BRAFLDRAFT_120622.1.1 m.26853 sp DPGN_DIPMA 30.909 330 144 11 75 354 34 329 4.90E-26 111 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; Q00PJ9 CHOYP_LOC101162818.1.1 m.9695 sp CAV1_ATEAB 43.651 126 69 2 31 155 48 172 4.90E-31 113 CAV1_ATEAB reviewed Caveolin-1 CAV1 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) 178 caveola assembly [GO:0070836]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; receptor internalization [GO:0031623]; T cell costimulation [GO:0031295] GO:0000139; GO:0005768; GO:0005901; GO:0030512; GO:0031295; GO:0031623; GO:0045121; GO:0070836 0 0 0 PF01146; Q05909 CHOYP_LOC100208023.8.8 m.49917 sp PTPRG_MOUSE 29.209 493 294 16 336 794 934 1405 4.90E-50 194 PTPRG_MOUSE reviewed Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) Ptprg Mus musculus (Mouse) 1442 negative regulation of epithelial cell migration [GO:0010633]; toxin transport [GO:1901998] GO:0004725; GO:0010633; GO:0016021; GO:0042802; GO:0070062; GO:1901998 0 0 0 PF00194;PF00041;PF00102; Q4LDE5 CHOYP_LOC100367084.14.22 m.52849 sp SVEP1_HUMAN 25.581 688 412 23 241 844 435 1106 4.90E-38 158 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q55FM5 CHOYP_MTPN.2.2 m.58730 sp MTPN_DICDI 55.172 116 52 0 34 149 5 120 4.90E-38 128 MTPN_DICDI reviewed Myotrophin homolog mtpn DDB_G0268038 Dictyostelium discoideum (Slime mold) 120 0 GO:0005634; GO:0005737 0 0 0 0 Q5VY43 CHOYP_DVIR_GJ12529.1.1 m.21031 sp PEAR1_HUMAN 32.374 417 240 19 177 581 438 824 4.90E-39 157 PEAR1_HUMAN reviewed Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) PEAR1 MEGF12 Homo sapiens (Human) 1037 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q6R7G0 CHOYP_LOC100695950.1.6 m.11109 sp Y068_OSHVF 22.461 699 443 20 1 607 1 692 4.90E-37 152 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q7M456 CHOYP_RNS2.1.2 m.35820 sp RNOY_CRAGI 36.022 186 111 4 27 204 3 188 4.90E-32 121 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q99126 CHOYP_CHS1.2.4 m.28744 sp CHS3_USTMA 25.263 380 225 12 452 779 520 892 4.90E-20 100 CHS3_USTMA reviewed Chitin synthase 3 (EC 2.4.1.16) (Chitin synthase I) (Chitin-UDP acetyl-glucosaminyl transferase 3) CHS3 CHS1 UMAG_10120 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 1029 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0030659; GO:0071555 0 0 0 PF01644;PF08407; Q9H0D2 CHOYP_LOC100901719.1.1 m.58836 sp ZN541_HUMAN 57 100 37 3 158 256 127 221 4.90E-28 121 ZN541_HUMAN reviewed Zinc finger protein 541 ZNF541 Homo sapiens (Human) 1346 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0006357; GO:0007275; GO:0007283; GO:0008134; GO:0030154; GO:0044212; GO:0046872 0 0 0 PF01448;PF13912; Q9H204 CHOYP_MED28.1.2 m.10181 sp MED28_HUMAN 52.727 110 52 0 39 148 38 147 4.90E-36 129 MED28_HUMAN reviewed Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1) MED28 EG1 FKSG20 Homo sapiens (Human) 178 "negative regulation of smooth muscle cell differentiation [GO:0051151]; regulation of transcription, DNA-templated [GO:0006355]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0016020; GO:0016592; GO:0019827; GO:0030864; GO:0051151 0 0 0 PF11594; Q9QZM5 CHOYP_ABI2.2.2 m.65629 sp ABI1_RAT 50.622 241 92 6 18 250 1 222 4.90E-66 221 ABI1_RAT reviewed Abl interactor 1 (Abelson interactor 1) (Abi-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) Abi1 Rattus norvegicus (Rat) 476 0 GO:0005634; GO:0005737; GO:0005856; GO:0008134; GO:0014069; GO:0030027; GO:0030054; GO:0030175; GO:0030426; GO:0045211 0 0 0 PF07815;PF00018; Q9V535 CHOYP_BRAFLDRAFT_251578.1.1 m.15566 sp RBM8A_DROME 65.663 166 54 2 21 184 1 165 4.90E-76 228 RBM8A_DROME reviewed RNA-binding protein 8A (Protein tsunagi) tsu Y14 CG8781 Drosophila melanogaster (Fruit fly) 165 "epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of pole plasm mRNA localization [GO:0046595]; germarium-derived oocyte fate determination [GO:0007294]; microtubule cytoskeleton organization [GO:0000226]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of transposition, DNA-mediated [GO:0000335]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte dorsal/ventral axis specification [GO:0007310]; oocyte nucleus migration involved in oocyte dorsal/ventral axis specification [GO:0007312]; pole plasm oskar mRNA localization [GO:0045451]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of pole plasm oskar mRNA localization [GO:0007317]; RNA splicing [GO:0008380]" GO:0000166; GO:0000184; GO:0000226; GO:0000335; GO:0000381; GO:0000398; GO:0003729; GO:0005634; GO:0005737; GO:0006406; GO:0007173; GO:0007294; GO:0007310; GO:0007312; GO:0007314; GO:0007317; GO:0008380; GO:0035145; GO:0045451; GO:0046595; GO:0071013 0 0 0 PF00076; A0MZ67 CHOYP_RAN.3.3 m.59027 sp SHOT1_RAT 31.25 352 198 11 8 343 1 324 4.91E-21 97.8 SHOT1_RAT reviewed Shootin-1 (Shootin1) Shtn1 Rattus norvegicus (Rat) 633 "actin filament bundle retrograde transport [GO:0061573]; axonogenesis [GO:0007409]; Cdc42 protein signal transduction [GO:0032488]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; endoplasmic reticulum polarization [GO:0061163]; netrin-activated signaling pathway [GO:0038007]; positive regulation of axon extension [GO:0045773]; positive regulation of neuron migration [GO:2001224]; Ras protein signal transduction [GO:0007265]; regulation of establishment of cell polarity [GO:2000114]; substrate-dependent cell migration, cell extension [GO:0006930]" GO:0005829; GO:0005875; GO:0006930; GO:0007265; GO:0007409; GO:0015630; GO:0030027; GO:0030175; GO:0030424; GO:0030426; GO:0031252; GO:0032488; GO:0038007; GO:0043204; GO:0044295; GO:0045773; GO:0048471; GO:0050839; GO:0051015; GO:0060327; GO:0061163; GO:0061573; GO:2000114; GO:2001224 0 0 0 0 A2ASS6 CHOYP_TTN.3.9 m.25653 sp TITIN_MOUSE 27.717 184 113 8 23 195 32423 32597 4.91E-09 62.4 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A7YY46 CHOYP_LOC101066924.1.1 m.16031 sp PNKD_BOVIN 45.307 309 160 4 28 332 80 383 4.91E-93 285 PNKD_BOVIN reviewed Probable hydrolase PNKD (EC 3.-.-.-) PNKD Bos taurus (Bovine) 385 "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [GO:0019243]; negative regulation of neurotransmitter secretion [GO:0046929]; neuromuscular process controlling posture [GO:0050884]; regulation of dopamine metabolic process [GO:0042053]; regulation of synaptic transmission, dopaminergic [GO:0032225]" GO:0004416; GO:0005739; GO:0016020; GO:0019243; GO:0032225; GO:0042053; GO:0046872; GO:0046929; GO:0050884 0 0 0 PF16123;PF00753; O35375 CHOYP_NRP2.6.8 m.57032 sp NRP2_MOUSE 30.364 247 137 12 70 297 45 275 4.91E-19 92.8 NRP2_MOUSE reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) Nrp2 Mus musculus (Mouse) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; heart development [GO:0007507]; negative chemotaxis [GO:0050919]; nerve development [GO:0021675]; neural crest cell migration [GO:0001755]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; neuron migration [GO:0001764]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649] GO:0001525; GO:0001755; GO:0001764; GO:0005021; GO:0005886; GO:0007411; GO:0007507; GO:0008201; GO:0016021; GO:0017154; GO:0021612; GO:0021649; GO:0021675; GO:0021828; GO:0030424; GO:0036486; GO:0046872; GO:0048846; GO:0050919; GO:0061549; GO:0061551; GO:0097374; GO:0097490; GO:0097491; GO:1901166; GO:1902285; GO:1903375; GO:1904835 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O43301 CHOYP_NEMVEDRAFT_V1G212312.5.5 m.58424 sp HS12A_HUMAN 30.253 671 396 20 964 1571 12 673 4.91E-80 282 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O61366 CHOYP_LOC100378444.1.2 m.7147 sp GPRS_DROME 28.293 205 115 3 120 292 14 218 4.91E-20 94.4 GPRS_DROME reviewed Serine-enriched protein gprs CG18471 Drosophila melanogaster (Fruit fly) 1302 0 0 0 0 0 PF07707;PF00651; P11497 CHOYP_ACACA.3.7 m.41506 sp ACACA_RAT 64.912 114 38 2 1 114 1441 1552 4.91E-42 150 ACACA_RAT reviewed Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)] Acaca Acac Rattus norvegicus (Rat) 2345 acetyl-CoA metabolic process [GO:0006084]; fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; protein homotetramerization [GO:0051289]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070] GO:0003989; GO:0004075; GO:0005524; GO:0005829; GO:0006084; GO:0006633; GO:0009374; GO:0014070; GO:0019900; GO:0042493; GO:0046872; GO:0051289; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; P34056 CHOYP_TCFAP2B.2.2 m.11727 sp AP2A_MOUSE 56.071 453 153 17 52 486 13 437 4.91E-125 374 AP2A_MOUSE reviewed Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2) Tfap2a Ap2tf Tcfap2a Mus musculus (Mouse) 437 "anterior neuropore closure [GO:0021506]; basement membrane organization [GO:0071711]; bone morphogenesis [GO:0060349]; cellular response to iron ion [GO:0071281]; cornea development in camera-type eye [GO:0061303]; embryonic body morphogenesis [GO:0010172]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic forelimb morphogenesis [GO:0035115]; embryonic pattern specification [GO:0009880]; epidermis morphogenesis [GO:0048730]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; forebrain neuron development [GO:0021884]; forelimb morphogenesis [GO:0035136]; inner ear morphogenesis [GO:0042472]; keratinocyte development [GO:0003334]; kidney development [GO:0001822]; lens induction in camera-type eye [GO:0060235]; lens morphogenesis in camera-type eye [GO:0002089]; metanephric nephron development [GO:0072210]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; neural crest cell development [GO:0014032]; neural tube closure [GO:0001843]; oculomotor nerve formation [GO:0021623]; optic cup structural organization [GO:0003409]; optic vesicle morphogenesis [GO:0003404]; outflow tract morphogenesis [GO:0003151]; palate development [GO:0060021]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of neuron differentiation [GO:0045664]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sensory organ development [GO:0007423]; sensory perception of sound [GO:0007605]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; sympathetic nervous system development [GO:0048485]; trigeminal nerve development [GO:0021559]" GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000979; GO:0000980; GO:0000981; GO:0000982; GO:0000987; GO:0001077; GO:0001078; GO:0001105; GO:0001106; GO:0001228; GO:0001822; GO:0001843; GO:0002089; GO:0003151; GO:0003334; GO:0003404; GO:0003409; GO:0003682; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005794; GO:0005813; GO:0006355; GO:0006357; GO:0007399; GO:0007423; GO:0007605; GO:0008285; GO:0009880; GO:0010172; GO:0010628; GO:0010944; GO:0014032; GO:0021506; GO:0021559; GO:0021623; GO:0021884; GO:0030335; GO:0030501; GO:0035115; GO:0035136; GO:0042059; GO:0042472; GO:0043066; GO:0043231; GO:0043524; GO:0043525; GO:0043565; GO:0043588; GO:0044212; GO:0045595; GO:0045664; GO:0045892; GO:0045893; GO:0045944; GO:0046983; GO:0048485; GO:0048596; GO:0048701; GO:0048705; GO:0048730; GO:0060021; GO:0060235; GO:0060325; GO:0060349; GO:0061029; GO:0061303; GO:0070172; GO:0071281; GO:0071711; GO:0072210; GO:2000378 0 0 0 PF03299; Q3UES3 CHOYP_TVAG_470020.1.8 m.19372 sp TNKS2_MOUSE 29.605 304 160 5 41 295 28 326 4.91E-27 118 TNKS2_MOUSE reviewed Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) Tnks2 Tank2 Mus musculus (Mouse) 1166 "multicellular organism growth [GO:0035264]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein polyubiquitination [GO:0000209]; regulation of multicellular organism growth [GO:0040014]; telomere maintenance [GO:0000723]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000242; GO:0000723; GO:0000781; GO:0003950; GO:0005634; GO:0005635; GO:0005737; GO:0006471; GO:0016055; GO:0019899; GO:0035264; GO:0040014; GO:0046872; GO:0048471; GO:0070198; GO:0070213; GO:0090263; GO:1904355; GO:1904357 0 0 0 PF00023;PF12796;PF00644;PF07647; Q4V920 CHOYP_AGAP_AGAP008046.1.1 m.58394 sp PACN1_DANRE 41.667 468 235 6 11 476 14 445 4.91E-131 389 PACN1_DANRE reviewed Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) pacsin1b pacsin1 Danio rerio (Zebrafish) (Brachydanio rerio) 445 actin filament organization [GO:0007015]; auditory receptor cell stereocilium organization [GO:0060088]; endocytosis [GO:0006897]; membrane tubulation [GO:0097320]; neuron projection morphogenesis [GO:0048812]; regulation of endocytosis [GO:0030100] GO:0005768; GO:0005829; GO:0006897; GO:0007015; GO:0008289; GO:0030054; GO:0030100; GO:0030659; GO:0032587; GO:0043005; GO:0045202; GO:0048812; GO:0060088; GO:0097320 0 0 0 PF00611;PF00018; Q864R9 CHOYP_MRP1.1.10 m.4185 sp MRP1_MACFA 65.693 137 46 1 2 138 1396 1531 4.91E-57 194 MRP1_MACFA reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 1531 0 GO:0005524; GO:0005886; GO:0016021; GO:0042626 0 0 0 PF00664;PF00005; Q8BGD9 CHOYP_RPB1.1.1 m.36613 sp IF4B_MOUSE 42.353 255 106 5 13 226 14 268 4.91E-41 162 IF4B_MOUSE reviewed Eukaryotic translation initiation factor 4B (eIF-4B) Eif4b Mus musculus (Mouse) 611 cytoplasmic translation [GO:0002181]; eukaryotic translation initiation factor 4F complex assembly [GO:0097010]; formation of translation preinitiation complex [GO:0001731] GO:0000166; GO:0001731; GO:0002181; GO:0003743; GO:0005844; GO:0016281; GO:0033592; GO:0034057; GO:0043024; GO:0044822; GO:0097010 0 0 0 PF00076; Q99M80 CHOYP_PTPRT.19.45 m.44020 sp PTPRT_MOUSE 32.017 709 429 17 691 1359 758 1453 4.91E-85 309 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9CQ74 CHOYP_OBRG.1.1 m.66700 sp LERL1_MOUSE 59.055 127 49 2 29 152 5 131 4.91E-45 147 LERL1_MOUSE reviewed Leptin receptor overlapping transcript-like 1 (Endospanin-2) Leprotl1 Mus musculus (Mouse) 131 0 GO:0016021 0 0 0 PF04133; Q9NQ86 CHOYP_LOC100369333.3.32 m.20473 sp TRI36_HUMAN 22.648 287 190 10 13 281 157 429 4.91E-08 59.7 TRI36_HUMAN reviewed E3 ubiquitin-protein ligase TRIM36 (EC 6.3.2.-) (RING finger protein 98) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) TRIM36 RBCC728 RNF98 Homo sapiens (Human) 728 acrosome reaction [GO:0007340]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726] GO:0000209; GO:0001669; GO:0004842; GO:0005829; GO:0005856; GO:0007340; GO:0008270; GO:0016874; GO:0051726; GO:0070062 0 0 0 PF00041;PF00643;PF13445; Q9QY36 CHOYP_LOC101165304.1.1 m.54576 sp NAA10_MOUSE 84.146 164 25 1 1 164 1 163 4.91E-102 295 NAA10_MOUSE reviewed N-alpha-acetyltransferase 10 (EC 2.3.1.-) (EC 2.3.1.88) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit Naa10) Naa10 Ard1 Ard1a Te2 Mus musculus (Mouse) 235 internal protein amino acid acetylation [GO:0006475]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; N-terminal peptidyl-serine acetylation [GO:0017198]; N-terminal protein amino acid acetylation [GO:0006474] GO:0005622; GO:0005634; GO:0005730; GO:0005737; GO:0006474; GO:0006475; GO:0008080; GO:0016020; GO:0017198; GO:0018002; GO:0022626; GO:0031415; GO:0043022; GO:1990189; GO:1990190 0 0 0 PF00583; Q9UJV3 CHOYP_NEMVEDRAFT_V1G198897.3.6 m.36118 sp TRIM1_HUMAN 22.455 334 232 9 12 327 30 354 4.91E-14 79.3 TRIM1_HUMAN reviewed Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (Tripartite motif-containing protein 1) MID2 FXY2 RNF60 TRIM1 Homo sapiens (Human) 735 innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567] GO:0005737; GO:0005874; GO:0008017; GO:0008270; GO:0010508; GO:0016567; GO:0016874; GO:0032897; GO:0035372; GO:0042803; GO:0043123; GO:0045087; GO:0046597; GO:0046982; GO:0051091; GO:0051092; GO:0051219; GO:0070062; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622;PF00643;PF13445; Q9ULJ7 CHOYP_LOC753709.42.44 m.64122 sp ANR50_HUMAN 33.115 610 380 20 62 647 496 1101 4.91E-56 211 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A2AVA0 CHOYP_LOC100378937.1.1 m.31756 sp SVEP1_MOUSE 25.75 633 385 19 272 853 2794 3392 4.92E-40 167 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; F1NUK7 CHOYP_BRAFLDRAFT_241287.1.1 m.5544 sp FLRT3_CHICK 26.531 392 225 11 16 402 25 358 4.92E-29 122 FLRT3_CHICK reviewed Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3) FLRT3 Gallus gallus (Chicken) 647 axon guidance [GO:0007411]; cell-cell adhesion [GO:0098609]; cytokine-mediated signaling pathway [GO:0019221]; embryonic morphogenesis [GO:0048598]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; heart development [GO:0007507]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; neuron projection development [GO:0031175]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]; proepicardium cell migration involved in pericardium morphogenesis [GO:0003345]; response to axon injury [GO:0048678]; synapse assembly [GO:0007416] GO:0003345; GO:0004860; GO:0005615; GO:0005737; GO:0005789; GO:0005887; GO:0005911; GO:0005925; GO:0006469; GO:0007411; GO:0007416; GO:0007507; GO:0008543; GO:0019221; GO:0031175; GO:0043679; GO:0044295; GO:0045499; GO:0046426; GO:0048598; GO:0048678; GO:0051965; GO:0060322; GO:0097060; GO:0098609; GO:1990138 0 0 0 PF13855; H2A0L8 CHOYP_FND2.1.4 m.8542 sp FND2_PINMG 47.109 588 284 8 19 585 33 614 4.92E-164 493 FND2_PINMG reviewed Fibronectin type III domain-containing protein 2 0 Pinctada margaritifera (Black-lipped pearl oyster) 624 0 GO:0005576 0 0 0 PF00041; O08623 CHOYP_SQSTM1.1.1 m.29189 sp SQSTM_RAT 59.184 49 20 0 53 101 120 168 4.92E-16 75.5 SQSTM_RAT reviewed Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62) Sqstm1 Zip Rattus norvegicus (Rat) 439 apoptotic process [GO:0006915]; autophagy [GO:0006914]; cell differentiation [GO:0030154]; immune system process [GO:0002376]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein phosphorylation [GO:0001934]; protein heterooligomerization [GO:0051291]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of protein complex stability [GO:0061635]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000407; GO:0000932; GO:0001934; GO:0002376; GO:0005080; GO:0005770; GO:0005776; GO:0005783; GO:0006511; GO:0006914; GO:0006915; GO:0008270; GO:0016235; GO:0016236; GO:0016239; GO:0016605; GO:0030154; GO:0031410; GO:0042169; GO:0042803; GO:0043122; GO:0043130; GO:0044130; GO:0044753; GO:0044754; GO:0051291; GO:0061635; GO:0070062; GO:0097225; GO:0098779 0 0 0 PF00564;PF00569; O15460 CHOYP_PHUM_PHUM445570.1.1 m.18708 sp P4HA2_HUMAN 46.568 539 274 7 1 534 1 530 4.92E-168 489 P4HA2_HUMAN reviewed "Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)" P4HA2 UNQ290/PRO330 Homo sapiens (Human) 535 0 GO:0004656; GO:0005506; GO:0005634; GO:0005737; GO:0005783; GO:0005788; GO:0009055; GO:0016702; GO:0031418; GO:0043231 0 0 0 PF13640;PF08336; O15990 CHOYP_BRAFLDRAFT_67316.1.1 m.5349 sp KARG_LIOJA 61.905 105 39 1 1 105 167 270 4.92E-41 140 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; P27701 CHOYP_LOC751836.4.6 m.40980 sp CD82_HUMAN 29.224 219 134 6 64 271 52 260 4.92E-15 76.3 CD82_HUMAN reviewed CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) CD82 KAI1 SAR2 ST6 TSPAN27 Homo sapiens (Human) 267 cell surface receptor signaling pathway [GO:0007166] GO:0005886; GO:0005887; GO:0007166; GO:0070062 0 0 0 PF00335; P28824 CHOYP_NRP2.4.8 m.24146 sp NRP1_XENLA 27.961 304 183 14 52 340 26 308 4.92E-17 87.4 NRP1_XENLA reviewed Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) 928 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; endothelial cell chemotaxis [GO:0035767]; organ morphogenesis [GO:0009887]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005021; GO:0007411; GO:0008201; GO:0009887; GO:0016021; GO:0017154; GO:0035767; GO:0046872; GO:0048010 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P70207 CHOYP_TSP_08514.1.1 m.19341 sp PLXA2_MOUSE 23.359 655 397 31 48 649 278 880 4.92E-32 137 PLXA2_MOUSE reviewed Plexin-A2 (Plex 2) (Plexin-2) Plxna2 Kiaa0463 Mus musculus (Mouse) 1894 branchiomotor neuron axon guidance [GO:0021785]; cell surface receptor signaling pathway [GO:0007166]; centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756] GO:0001756; GO:0002116; GO:0005886; GO:0005887; GO:0007166; GO:0017154; GO:0021785; GO:0021915; GO:0021935; GO:0030334; GO:0048841; GO:0051642; GO:0060037; GO:0060174; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; P84875 CHOYP_BOOG2.1.1 m.52523 sp PCPI_SABMA 43.363 113 61 2 49 161 56 165 4.92E-22 89.7 PCPI_SABMA reviewed Carboxypeptidase inhibitor SmCI 0 Sabellastarte magnifica (Feather duster) 165 0 GO:0004867; GO:0008191 0 0 0 PF00014; P86854 CHOYP_SI_CH211-125E6.14.1.2 m.26825 sp PLCL_MYTGA 30.469 128 86 3 29 154 30 156 4.92E-17 76.6 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q05A80 CHOYP_CBLN13.1.9 m.4529 sp CAPR2_MOUSE 30.827 133 82 5 261 387 900 1028 4.92E-10 65.1 CAPR2_MOUSE reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) 1031 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q23808 CHOYP_BRAFLDRAFT_200162.4.4 m.59316 sp AQP_CICVR 33.73 252 142 10 3 247 8 241 4.92E-29 114 AQP_CICVR reviewed Aquaporin AQPcic AQP CIC Cicadella viridis (Green leafhopper) 255 0 GO:0005215; GO:0016021 0 0 cd00333; PF00230; Q32LE3 CHOYP_CETN1.3.3 m.63231 sp CETN1_BOVIN 78.659 164 35 0 2 165 9 172 4.92E-92 268 CETN1_BOVIN reviewed Centrin-1 CETN1 Bos taurus (Bovine) 172 cell division [GO:0051301]; cellular response to heat [GO:0034605]; mitotic nuclear division [GO:0007067] GO:0000922; GO:0005509; GO:0005814; GO:0007067; GO:0032391; GO:0034605; GO:0051301 0 0 0 PF13499;PF13833; Q4V7V8 CHOYP_ADAT2.1.1 m.16533 sp ADAT2_XENLA 59.281 167 66 1 33 199 11 175 4.92E-70 213 ADAT2_XENLA reviewed tRNA-specific adenosine deaminase 2 (EC 3.5.4.-) (Deaminase domain-containing protein 1) (tRNA-specific adenosine-34 deaminase subunit ADAT2) adat2 deadc1 Xenopus laevis (African clawed frog) 175 tRNA wobble adenosine to inosine editing [GO:0002100] GO:0002100; GO:0008251; GO:0008270 0 0 0 PF00383; Q5BIM1 CHOYP_LOC100691423.1.1 m.48936 sp TRI45_BOVIN 22.741 343 211 11 2 308 18 342 4.92E-13 73.6 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6DIB5 CHOYP_MEG10.78.91 m.58714 sp MEG10_MOUSE 34.699 415 207 17 194 561 271 668 4.92E-46 182 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q8BHN0 CHOYP_LOC100377829.2.2 m.13867 sp PPM1L_MOUSE 48.58 352 159 7 26 361 6 351 4.92E-107 321 PPM1L_MOUSE reviewed Protein phosphatase 1L (EC 3.1.3.16) (Protein phosphatase 1-like) (Protein phosphatase 2C isoform epsilon) (PP2C-epsilon) Ppm1l Kiaa4175 Mus musculus (Mouse) 360 MAPK cascade [GO:0000165]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178] GO:0000165; GO:0004722; GO:0005622; GO:0007178; GO:0016021; GO:0046872; GO:0070062 0 0 0 PF00481; Q96J86 CHOYP_contig_049880 m.59273 sp CYYR1_HUMAN 33.813 139 75 7 4 136 17 144 4.92E-06 47.4 CYYR1_HUMAN reviewed Cysteine and tyrosine-rich protein 1 (Proline-rich domain-containing protein) CYYR1 C21orf95 Homo sapiens (Human) 154 0 GO:0016021 0 0 0 PF10873; Q96QU1 CHOYP_FAT4.1.10 m.2578 sp PCD15_HUMAN 29.817 436 265 18 124 546 615 1022 4.92E-31 136 PCD15_HUMAN reviewed Protocadherin-15 PCDH15 USH1F Homo sapiens (Human) 1955 equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0001750; GO:0005509; GO:0005615; GO:0005886; GO:0007156; GO:0007605; GO:0016021; GO:0032420; GO:0045202; GO:0045494; GO:0048839; GO:0050953; GO:0050957; GO:0070062 0 0 0 PF00028; Q9H251 CHOYP_LOC100879829.1.1 m.49126 sp CAD23_HUMAN 30.861 1429 858 44 83 1475 84 1418 4.92E-144 502 CAD23_HUMAN reviewed Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) 3354 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0005509; GO:0005886; GO:0006816; GO:0007156; GO:0007601; GO:0007605; GO:0007626; GO:0016020; GO:0016021; GO:0016339; GO:0032420; GO:0045494; GO:0050896; GO:0050953; GO:0050957; GO:0051480; GO:0060122 0 0 0 PF00028; Q9P2N4 CHOYP_ATS9.2.3 m.45970 sp ATS9_HUMAN 52.817 426 191 7 1 423 411 829 4.92E-148 465 ATS9_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-) ADAMTS9 KIAA1312 Homo sapiens (Human) 1935 glycoprotein catabolic process [GO:0006516]; multicellular organism development [GO:0007275]; positive regulation of melanocyte differentiation [GO:0045636]; protein transport [GO:0015031]; proteolysis [GO:0006508]; vesicle-mediated transport [GO:0016192] GO:0004222; GO:0005578; GO:0005615; GO:0005783; GO:0006508; GO:0006516; GO:0007275; GO:0008237; GO:0008270; GO:0009986; GO:0015031; GO:0016192; GO:0045636 0 0 0 PF05986;PF08685;PF01562;PF01421;PF00090; Q9R0W9 CHOYP_BRAFLDRAFT_217532.1.1 m.62177 sp ACHA6_MOUSE 27.044 318 220 6 20 330 32 344 4.92E-32 129 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9XZC0 CHOYP_LCTA.1.1 m.65362 sp LCTA_LATTR 26.316 171 105 4 751 901 676 845 4.92E-08 60.8 LCTA_LATTR reviewed Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1) (Fragment) 0 Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) 1413 exocytosis [GO:0006887] GO:0005576; GO:0006887; GO:0016021; GO:0072556 0 0 0 PF12796;PF13606; O01393 CHOYP_LOC100533356.2.6 m.12535 sp UNC9_CAEEL 33.758 157 97 2 2 158 235 384 4.93E-22 94.4 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O70277 CHOYP_LOC100632153.1.6 m.12707 sp TRIM3_RAT 24.201 219 146 5 361 571 538 744 4.93E-09 62.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88545 CHOYP_LOC592528.1.2 m.17290 sp CSN6_MOUSE 72.403 308 84 1 38 345 18 324 4.93E-171 481 CSN6_MOUSE reviewed COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) Cops6 Csn6 Mus musculus (Mouse) 324 cullin deneddylation [GO:0010388] GO:0005654; GO:0005737; GO:0008180; GO:0010388; GO:0070062 0 0 0 PF01398;PF13012; O96102 CHOYP_CALM.45.50 m.57163 sp CALM_PHYPO 54.861 144 62 1 4 144 5 148 4.93E-53 167 CALM_PHYPO reviewed Calmodulin (CaM) 0 Physarum polycephalum (Slime mold) 149 0 GO:0005509 0 0 0 PF13499; P10155 CHOYP_LOC100377747.2.3 m.55118 sp RO60_HUMAN 40.909 550 277 14 33 579 9 513 4.93E-121 370 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P18503 CHOYP_BRAFLDRAFT_117253.1.1 m.27258 sp CAS4_EPHMU 28.643 199 104 10 89 280 198 365 4.93E-06 50.8 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P51942 CHOYP_LOC100962815.1.1 m.33034 sp MATN1_MOUSE 26.039 361 211 11 109 421 39 391 4.93E-22 102 MATN1_MOUSE reviewed Cartilage matrix protein (Matrilin-1) Matn1 Cmp Crtm Mus musculus (Mouse) 500 chondrocyte differentiation [GO:0002062]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; regulation of bone mineralization [GO:0030500] GO:0002062; GO:0003429; GO:0005201; GO:0005509; GO:0005578; GO:0030500 0 0 0 PF10393;PF00092; Q13207 CHOYP_BRAFLDRAFT_124787.1.1 m.10002 sp TBX2_HUMAN 60.352 227 87 2 68 294 80 303 4.93E-95 306 TBX2_HUMAN reviewed T-box transcription factor TBX2 (T-box protein 2) TBX2 Homo sapiens (Human) 712 "aorta morphogenesis [GO:0035909]; atrioventricular canal development [GO:0036302]; cardiac muscle tissue development [GO:0048738]; cell aging [GO:0007569]; cellular senescence [GO:0090398]; developmental growth involved in morphogenesis [GO:0060560]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic heart tube development [GO:0035050]; endocardial cushion morphogenesis [GO:0003203]; heart looping [GO:0001947]; mammary placode formation [GO:0060596]; muscle cell fate determination [GO:0007521]; negative regulation of cardiac chamber formation [GO:1901211]; negative regulation of heart looping [GO:1901208]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; palate development [GO:0060021]; pharynx development [GO:0060465]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation [GO:0008284]; regulation of heart contraction [GO:0008016]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000978; GO:0001078; GO:0001947; GO:0003148; GO:0003151; GO:0003203; GO:0003256; GO:0003677; GO:0005634; GO:0005667; GO:0006351; GO:0007219; GO:0007521; GO:0007569; GO:0008016; GO:0008284; GO:0035050; GO:0035909; GO:0036302; GO:0042733; GO:0043565; GO:0045892; GO:0048596; GO:0048738; GO:0060021; GO:0060045; GO:0060465; GO:0060560; GO:0060596; GO:0090398; GO:1901208; GO:1901211 0 0 0 PF00907;PF12598; Q15262 CHOYP_PTPRC.13.14 m.49977 sp PTPRK_HUMAN 32.258 527 324 11 153 654 886 1404 4.93E-75 266 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q2HJM9 CHOYP_MEST.2.2 m.55066 sp MEST_BOVIN 47.634 317 157 5 8 315 15 331 4.93E-90 275 MEST_BOVIN reviewed Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) MEST PEG1 Bos taurus (Bovine) 335 mesoderm development [GO:0007498]; regulation of lipid storage [GO:0010883] GO:0005783; GO:0005789; GO:0007498; GO:0010883; GO:0016021; GO:0016787 0 0 0 PF00561; Q7M456 CHOYP_RNS7.1.1 m.22640 sp RNOY_CRAGI 34.524 168 93 7 16 170 25 188 4.93E-22 93.2 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q8C525 CHOYP_LOC100375194.2.7 m.24601 sp M21D2_MOUSE 22.388 134 95 3 135 262 223 353 4.93E-06 52.4 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8IV33 CHOYP_LOC100889442.1.1 m.43938 sp K0825_HUMAN 26.111 720 469 21 2 694 577 1260 4.93E-51 196 K0825_HUMAN reviewed Uncharacterized protein KIAA0825 KIAA0825 C5orf36 Homo sapiens (Human) 1275 0 0 0 0 0 PF14906; Q9D6K9 CHOYP_CERS6.1.1 m.5214 sp CERS5_MOUSE 48.06 335 172 2 26 359 16 349 4.93E-108 326 CERS5_MOUSE reviewed Ceramide synthase 5 (CerS5) (EC 2.3.1.24) (LAG1 longevity assurance homolog 5) (Translocating chain-associating membrane protein homolog 4) (TRAM homolog 4) Cers5 Lass5 Trh4 Mus musculus (Mouse) 414 ceramide biosynthetic process [GO:0046513]; sphingolipid biosynthetic process [GO:0030148] GO:0003677; GO:0005783; GO:0005789; GO:0016021; GO:0030148; GO:0031965; GO:0046513; GO:0050291 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00046;PF03798; Q9H5P4 CHOYP_PDZD7B.1.1 m.64961 sp PDZD7_HUMAN 46.729 214 105 3 133 342 97 305 4.93E-49 186 PDZD7_HUMAN reviewed PDZ domain-containing protein 7 PDZD7 PDZK7 Homo sapiens (Human) 517 auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184] GO:0002141; GO:0005615; GO:0005634; GO:0005929; GO:0045184; GO:0050910; GO:0060088; GO:1990696 0 0 0 PF00595; Q9NYV6 CHOYP_LOC100565661.1.1 m.11633 sp RRN3_HUMAN 41.463 574 306 10 17 568 62 627 4.93E-140 424 RRN3_HUMAN reviewed RNA polymerase I-specific transcription initiation factor RRN3 (Transcription initiation factor IA) (TIF-IA) RRN3 TIFIA Homo sapiens (Human) 651 "cell proliferation [GO:0008283]; cytoplasm organization [GO:0007028]; homeostasis of number of cells [GO:0048872]; in utero embryonic development [GO:0001701]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; nucleolus organization [GO:0007000]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of DNA-templated transcription, initiation [GO:2000142]; ribosome biogenesis [GO:0042254]; transcription initiation from RNA polymerase I promoter [GO:0006361]" GO:0001164; GO:0001701; GO:0005634; GO:0005654; GO:0005730; GO:0006361; GO:0007000; GO:0007028; GO:0008283; GO:0010976; GO:0042254; GO:0045893; GO:0048872; GO:1902254; GO:2000142 0 0 0 PF05327; Q9VVE2 CHOYP_AGAP_AGAP006653.1.1 m.25149 sp ROGDI_DROME 39.918 243 136 5 23 265 18 250 4.93E-55 181 ROGDI_DROME reviewed Protein rogdi rogdi CG7725 Drosophila melanogaster (Fruit fly) 268 behavioral response to ethanol [GO:0048149]; learning or memory [GO:0007611]; olfactory learning [GO:0008355] GO:0005635; GO:0007611; GO:0008355; GO:0048149 0 0 0 PF10259; A6BM72 CHOYP_LOC100490321.1.2 m.24294 sp MEG11_HUMAN 37.437 398 220 18 194 581 262 640 4.94E-53 198 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; A7YY35 CHOYP_IFRX2.4.10 m.15894 sp K2012_BOVIN 36.22 254 156 3 1432 1680 891 1143 4.94E-25 117 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; B3RNE8 CHOYP_LOC100372923.1.1 m.29834 sp ATAT_TRIAD 49.327 223 99 4 1 210 1 222 4.94E-64 209 ATAT_TRIAD reviewed Alpha-tubulin N-acetyltransferase (Alpha-TAT) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) TRIADDRAFT_53139 Trichoplax adhaerens (Trichoplax reptans) 238 alpha-tubulin acetylation [GO:0071929]; regulation of microtubule cytoskeleton organization [GO:0070507] GO:0005874; GO:0019799; GO:0070507; GO:0071929 0 0 0 PF05301; C3Z1P5 CHOYP_RU1C.1.2 m.50387 sp RU1C_BRAFL 80.303 66 13 0 1 66 1 66 4.94E-37 128 RU1C_BRAFL reviewed U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) BRAFLDRAFT_69314 Branchiostoma floridae (Florida lancelet) (Amphioxus) 221 mRNA 5'-splice site recognition [GO:0000395]; spliceosomal snRNP assembly [GO:0000387] GO:0000243; GO:0000387; GO:0000395; GO:0003729; GO:0005685; GO:0008270; GO:0030619; GO:0030627; GO:0071004; GO:0071010 0 0 0 PF06220; O00370 CHOYP_LOC100368926.3.5 m.40575 sp LORF2_HUMAN 28.571 147 102 2 43 188 685 829 4.94E-09 58.5 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; O43315 CHOYP_LOC100373328.1.1 m.2851 sp AQP9_HUMAN 45.907 281 151 1 2 282 9 288 4.94E-82 252 AQP9_HUMAN reviewed Aquaporin-9 (AQP-9) (Aquaglyceroporin-9) (Small solute channel 1) AQP9 SSC1 Homo sapiens (Human) 295 amine transport [GO:0015837]; canalicular bile acid transport [GO:0015722]; carboxylic acid transport [GO:0046942]; cellular response to cAMP [GO:0071320]; cellular water homeostasis [GO:0009992]; excretion [GO:0007588]; glycerol transport [GO:0015793]; immune response [GO:0006955]; metabolic process [GO:0008152]; polyol transport [GO:0015791]; purine nucleobase transport [GO:0006863]; pyrimidine nucleobase transport [GO:0015855]; response to mercury ion [GO:0046689]; response to organic substance [GO:0010033]; response to osmotic stress [GO:0006970]; transport [GO:0006810]; urea transmembrane transport [GO:0071918]; water homeostasis [GO:0030104]; water transport [GO:0006833] GO:0005275; GO:0005345; GO:0005350; GO:0005372; GO:0005886; GO:0005887; GO:0006810; GO:0006833; GO:0006863; GO:0006955; GO:0006970; GO:0007588; GO:0008152; GO:0009992; GO:0010033; GO:0015166; GO:0015204; GO:0015250; GO:0015254; GO:0015265; GO:0015288; GO:0015722; GO:0015791; GO:0015793; GO:0015837; GO:0015855; GO:0016021; GO:0016323; GO:0030104; GO:0043231; GO:0046689; GO:0046942; GO:0046943; GO:0071320; GO:0071918 0 0 cd00333; PF00230; P09481 CHOYP_ACR3.1.1 m.8804 sp ACHA3_CHICK 30.063 316 209 5 35 342 27 338 4.94E-41 154 ACHA3_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) 496 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; P22031 CHOYP_NEMVEDRAFT_V1G111951.1.1 m.18549 sp LEG_HELCR 44.444 90 48 1 248 335 13 102 4.94E-19 85.1 LEG_HELCR reviewed D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 105 0 GO:0005737; GO:0030246 0 0 0 PF02140; P42674 CHOYP_LOC593467.1.4 m.52495 sp BP10_PARLI 37.818 275 153 7 161 429 73 335 4.94E-46 171 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P55043 CHOYP_LOC100865163.5.5 m.56364 sp RAD_RAT 32.71 214 130 4 199 406 91 296 4.94E-24 104 RAD_RAT reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) Rrad Rad Rattus norvegicus (Rat) 306 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; Q08420 CHOYP_LOC101169658.2.3 m.20752 sp SODE_RAT 25.654 191 112 8 147 323 48 222 4.94E-09 59.3 SODE_RAT reviewed Extracellular superoxide dismutase [Cu-Zn] (EC-SOD) (EC 1.15.1.1) (Superoxide dismutase B) Sod3 Sod-3 Rattus norvegicus (Rat) 244 response to copper ion [GO:0046688]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]; response to superoxide [GO:0000303] GO:0000303; GO:0001666; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005802; GO:0006979; GO:0008270; GO:0031012; GO:0046688; GO:0070062 0 0 cd00305; PF00080; Q5R4I3 CHOYP_UBXN4.1.1 m.22642 sp UBXN4_PONAB 34.18 512 274 11 1 453 1 508 4.94E-76 249 UBXN4_PONAB reviewed UBX domain-containing protein 4 (UBX domain-containing protein 2) UBXN4 UBXD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 508 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; response to unfolded protein [GO:0006986] GO:0005635; GO:0005789; GO:0006986; GO:0030433 0 0 0 PF00789; Q66IC8 CHOYP_LOC588988.1.1 m.48806 sp TC1D1_DANRE 43.333 120 66 1 88 207 56 173 4.94E-31 114 TC1D1_DANRE reviewed Tctex1 domain-containing protein 1 tctex1d1 zgc:101774 Danio rerio (Zebrafish) (Brachydanio rerio) 173 0 0 0 0 0 PF03645; Q6IP50 CHOYP_LOC100882159.1.1 m.37332 sp UBX1A_XENLA 57.609 92 39 0 1 92 76 167 4.94E-12 63.5 UBX1A_XENLA reviewed UBX domain-containing protein 1-A (SAPK substrate protein 1-A) ubxn1-a saks1-a Xenopus laevis (African clawed frog) 296 0 GO:0005737 0 0 0 PF00627;PF00789; Q80UU2 CHOYP_RPP38.1.1 m.15228 sp RPP38_MOUSE 31.746 126 80 2 162 287 104 223 4.94E-16 81.3 RPP38_MOUSE reviewed Ribonuclease P protein subunit p38 (RNaseP protein p38) (EC 3.1.26.5) Rpp38 Mus musculus (Mouse) 280 "RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; tRNA processing [GO:0008033]" GO:0004526; GO:0005655; GO:0005730; GO:0008033; GO:0090502 0 0 0 PF01248; Q9BX66 CHOYP_LOC100867381.2.8 m.14977 sp SRBS1_HUMAN 31.215 724 346 29 466 1117 286 929 4.94E-58 224 SRBS1_HUMAN reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) 1292 cell-matrix adhesion [GO:0007160]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; muscle contraction [GO:0006936]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0003779; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005913; GO:0005915; GO:0005924; GO:0005925; GO:0006936; GO:0007160; GO:0008092; GO:0008286; GO:0015758; GO:0016363; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q9NR21 CHOYP_LOC101161108.1.1 m.52561 sp PAR11_HUMAN 36.154 130 80 2 513 640 113 241 4.94E-20 95.9 PAR11_HUMAN reviewed Poly [ADP-ribose] polymerase 11 (PARP-11) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) PARP11 C12orf6 Homo sapiens (Human) 331 cell differentiation [GO:0030154]; mRNA transport [GO:0051028]; nuclear envelope organization [GO:0006998]; protein transport [GO:0015031]; spermatogenesis [GO:0007283] GO:0003950; GO:0005635; GO:0005643; GO:0006998; GO:0007283; GO:0015031; GO:0030154; GO:0051028 0 0 0 PF00644;PF02825; B5X4Y9 CHOYP_PTER.2.2 m.36064 sp PTER_SALSA 65.812 117 40 0 5 121 231 347 4.95E-52 170 PTER_SALSA reviewed Phosphotriesterase-related protein (EC 3.1.-.-) (Parathion hydrolase-related protein) pter Salmo salar (Atlantic salmon) 349 catabolic process [GO:0009056] GO:0008270; GO:0009056; GO:0016787 0 0 cd00530; PF02126; C3YWU0 CHOYP_LOC592142.8.9 m.62271 sp FUCO_BRAFL 42.593 108 57 2 26 133 346 448 4.95E-22 93.2 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; P02502 CHOYP_DPER_GL22446.1.1 m.52311 sp CRYAA_MACRU 31.507 73 49 1 1 72 79 151 4.95E-06 47.4 CRYAA_MACRU reviewed Alpha-crystallin A chain CRYAA Macropus rufus (Red kangaroo) (Megaleia rufa) 173 0 GO:0005212; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF00525;PF00011; P13214 CHOYP_LOC100367736.1.2 m.49130 sp ANXA4_BOVIN 53.465 303 141 0 7 309 12 314 4.95E-107 317 ANXA4_BOVIN reviewed Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Carbohydrate-binding protein p33/p41) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) ANXA4 ANX4 Bos taurus (Bovine) 319 epithelial cell differentiation [GO:0030855]; negative regulation of interleukin-8 secretion [GO:2000483]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; Notch signaling pathway [GO:0007219]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0005509; GO:0005544; GO:0005634; GO:0005829; GO:0006357; GO:0007219; GO:0008201; GO:0009986; GO:0016020; GO:0016324; GO:0030246; GO:0030855; GO:0031965; GO:0032088; GO:0035374; GO:0042584; GO:0042802; GO:0048306; GO:0048471; GO:0070062; GO:2000483 0 0 0 PF00191; P16157 CHOYP_contig_028655 m.32576 sp ANK1_HUMAN 37.751 249 155 0 2 250 238 486 4.95E-43 159 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P25390 CHOYP_BRAFLDRAFT_81321.1.10 m.22117 sp SSK22_YEAST 28.105 153 86 6 254 404 1039 1169 4.95E-06 52.8 SSK22_YEAST reviewed Serine/threonine-protein kinase SSK22 (EC 2.7.11.1) (MAP kinase kinase kinase SSK22) (Suppressor of sensor kinase 22) SSK22 YCR073C YCR73C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1331 MAPK cascade involved in osmosensory signaling pathway [GO:0000161]; stress-activated MAPK cascade [GO:0051403] GO:0000161; GO:0004702; GO:0004709; GO:0005524; GO:0005737; GO:0051403 0 0 0 PF00069; P32238 CHOYP_LOC101076498.1.2 m.23548 sp CCKAR_HUMAN 22.738 409 265 17 12 405 6 378 4.95E-07 55.5 CCKAR_HUMAN reviewed Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR CCKRA Homo sapiens (Human) 428 actin cytoskeleton reorganization [GO:0031532]; axonogenesis [GO:0007409]; cellular response to hormone stimulus [GO:0032870]; digestion [GO:0007586]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; gastric acid secretion [GO:0001696]; insulin secretion [GO:0030073]; neuron migration [GO:0001764]; organ regeneration [GO:0031100]; pancreas development [GO:0031016]; pancreatic juice secretion [GO:0030157]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of somatostatin secretion [GO:0090274]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of calcium ion transport [GO:0051924]; regulation of hormone secretion [GO:0046883]; regulation of potassium ion transport [GO:0043266]; response to glucocorticoid [GO:0051384]; response to heat [GO:0009408]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to radiation [GO:0009314]; response to starvation [GO:0042594]; temperature homeostasis [GO:0001659] GO:0001659; GO:0001696; GO:0001764; GO:0002023; GO:0004951; GO:0005764; GO:0005768; GO:0005783; GO:0005829; GO:0005886; GO:0005887; GO:0007200; GO:0007204; GO:0007409; GO:0007584; GO:0007586; GO:0007631; GO:0009314; GO:0009408; GO:0030073; GO:0030157; GO:0030900; GO:0031016; GO:0031100; GO:0031532; GO:0032496; GO:0032870; GO:0042594; GO:0043195; GO:0043266; GO:0046883; GO:0051384; GO:0051924; GO:0090274 0 0 0 PF00001;PF09193; Q07E28 CHOYP_TVAG_388180.7.8 m.61153 sp CTTB2_NEONE 39.073 151 86 2 14 158 687 837 4.95E-21 92 CTTB2_NEONE reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Neofelis nebulosa (Clouded leopard) 1658 0 GO:0005938; GO:0043197 0 0 0 PF00023;PF12796;PF09727; Q32KX7 CHOYP_BMI1B.1.1 m.59466 sp BMI1_BOVIN 50.222 225 95 4 1 208 1 225 4.95E-66 226 BMI1_BOVIN reviewed Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) BMI1 PCGF4 Bos taurus (Bovine) 326 "brain development [GO:0007420]; DNA methylation [GO:0006306]; embryonic skeletal system morphogenesis [GO:0048704]; histone acetylation [GO:0016573]; histone ubiquitination [GO:0016574]; humoral immune response [GO:0006959]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immature T cell proliferation in thymus [GO:0033092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; rostrocaudal neural tube patterning [GO:0021903]; somatic stem cell division [GO:0048103]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000151; GO:0000792; GO:0001701; GO:0005737; GO:0006306; GO:0006351; GO:0006959; GO:0007420; GO:0008270; GO:0016573; GO:0016574; GO:0016604; GO:0021903; GO:0030890; GO:0031519; GO:0033092; GO:0043565; GO:0045814; GO:0048103; GO:0048704; GO:0051443; GO:0097027; GO:1990841; GO:2001234 0 0 0 PF16207; Q496A3 CHOYP_LOC100374662.2.6 m.17014 sp SPAS1_HUMAN 38.926 149 83 2 107 249 142 288 4.95E-20 90.1 SPAS1_HUMAN reviewed Spermatogenesis-associated serine-rich protein 1 SPATS1 Homo sapiens (Human) 300 0 0 0 0 0 PF15160; Q496A3 CHOYP_LOC100374662.4.6 m.22422 sp SPAS1_HUMAN 38.926 149 83 2 107 249 142 288 4.95E-20 90.1 SPAS1_HUMAN reviewed Spermatogenesis-associated serine-rich protein 1 SPATS1 Homo sapiens (Human) 300 0 0 0 0 0 PF15160; Q4L818 CHOYP_BRAFLDRAFT_96927.1.3 m.37445 sp PDP_STAHJ 34.375 96 62 1 1 96 324 418 4.95E-10 58.5 PDP_STAHJ reviewed Pyrimidine-nucleoside phosphorylase (PYNP) (Py-NPase) (EC 2.4.2.2) pdp pyn SH0898 Staphylococcus haemolyticus (strain JCSC1435) 433 pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213] GO:0004645; GO:0006206; GO:0006213; GO:0016154; GO:0046872 0 0 0 PF02885;PF00591;PF07831; Q502M6 CHOYP_TVAG_227760.3.4 m.32948 sp ANR29_DANRE 37.838 222 137 1 14 235 31 251 4.95E-42 147 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q54KA7 CHOYP_contig_051382 m.61394 sp SECG_DICDI 37.701 374 232 1 1 373 109 482 4.95E-59 209 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q61847 CHOYP_NEMVEDRAFT_V1G120119.2.2 m.50513 sp MEP1B_MOUSE 31.144 472 237 21 9 444 9 428 4.95E-45 169 MEP1B_MOUSE reviewed Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) Mep1b Mep-1b Mus musculus (Mouse) 704 inflammatory response [GO:0006954]; toxin transport [GO:1901998] GO:0004222; GO:0005576; GO:0005886; GO:0006954; GO:0008270; GO:0016020; GO:0016021; GO:1901998 0 0 cd06263; PF01400;PF00008;PF00629; Q66I67 CHOYP_LOC100371443.1.1 m.15017 sp IFT20_DANRE 76.744 129 30 0 14 142 4 132 4.95E-66 199 IFT20_DANRE reviewed Intraflagellar transport protein 20 homolog ift20 zgc:103674 Danio rerio (Zebrafish) (Brachydanio rerio) 132 centrosome localization [GO:0051642]; cilium assembly [GO:0042384]; intraciliary transport [GO:0042073]; protein localization to cilium [GO:0061512]; protein localization to Golgi apparatus [GO:0034067] GO:0005794; GO:0005813; GO:0005814; GO:0005930; GO:0030992; GO:0034067; GO:0036064; GO:0042073; GO:0042384; GO:0051642; GO:0061512 0 0 0 PF14931; Q6DIB5 CHOYP_MEG10.89.91 m.65194 sp MEG10_MOUSE 38.14 215 107 9 8 207 355 558 4.95E-29 117 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6P7W2 CHOYP_SHKB1.1.1 m.60939 sp SHKB1_MOUSE 47.586 290 105 7 2 284 17 266 4.95E-74 243 SHKB1_MOUSE reviewed SH3KBP1-binding protein 1 (SETA-binding protein 1) Shkbp1 Sb1 Mus musculus (Mouse) 704 positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; protein homooligomerization [GO:0051260] GO:0045742; GO:0051260 0 0 0 PF02214; Q6R7E1 CHOYP_Y028.1.1 m.30879 sp Y088_OSHVF 27.811 507 305 23 41 527 145 610 4.95E-22 104 Y088_OSHVF reviewed Putative transmembrane protein ORF88 ORF88 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 748 0 GO:0016021; GO:0033644 0 0 0 0 Q8JIS3 CHOYP_BRAFLDRAFT_200527.1.1 m.601 sp DER_CHICK 55.649 239 106 0 2 240 4 242 4.95E-93 276 DER_CHICK reviewed D-erythrulose reductase (EC 1.1.1.162) (Probable L-xylulose reductase) (XR) (EC 1.1.1.10) DER Gallus gallus (Chicken) 246 D-xylose metabolic process [GO:0042732] GO:0005737; GO:0042732; GO:0047880; GO:0050038 0 0 0 0 Q8TB61 CHOYP_LOC578873.1.1 m.7193 sp S35B2_HUMAN 52.887 433 190 9 22 451 1 422 4.95E-146 426 S35B2_HUMAN reviewed Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2) SLC35B2 PAPST1 PSEC0149 Homo sapiens (Human) 432 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; 3'-phosphoadenosine 5'-phosphosulfate transport [GO:0046963]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0000139; GO:0004871; GO:0005794; GO:0016020; GO:0016021; GO:0030173; GO:0030176; GO:0043123; GO:0046963; GO:0046964; GO:0050428 0 0 0 PF08449; Q99081 CHOYP_HTF4.2.5 m.18247 sp HTF4_HUMAN 36.878 724 293 35 45 683 13 657 4.95E-77 264 HTF4_HUMAN reviewed Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4) TCF12 BHLHB20 HEB HTF4 Homo sapiens (Human) 682 immune response [GO:0006955]; muscle organ development [GO:0007517]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000790; GO:0000978; GO:0001077; GO:0003700; GO:0005634; GO:0005737; GO:0006357; GO:0006955; GO:0007517; GO:0008134; GO:0035326; GO:0035497; GO:0042803; GO:0043425; GO:0045666; GO:0045944; GO:0046332; GO:0046982; GO:0070888; GO:0090575 0 0 0 PF00010; Q99638 CHOYP_LOC100891745.1.1 m.47875 sp RAD9A_HUMAN 37.554 466 213 12 1 464 1 390 4.95E-91 285 RAD9A_HUMAN reviewed Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) RAD9A Homo sapiens (Human) 391 cellular response to DNA damage stimulus [GO:0006974]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication checkpoint [GO:0000076]; intra-S DNA damage checkpoint [GO:0031573]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; regulation of signal transduction by p53 class mediator [GO:1901796] GO:0000076; GO:0000077; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006281; GO:0006974; GO:0008408; GO:0008853; GO:0017124; GO:0019899; GO:0019901; GO:0030896; GO:0031573; GO:0042826; GO:0071479; GO:1901796; GO:1902231 0 0 0 PF04139; Q99JY8 CHOYP_MP.1.4 m.5731 sp PLPP3_MOUSE 39.024 205 93 6 3 203 20 196 4.95E-33 123 PLPP3_MOUSE reviewed Phospholipid phosphatase 3 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) Plpp3 Lpp3 Ppap2b Mus musculus (Mouse) 312 Bergmann glial cell differentiation [GO:0060020]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion [GO:0044329]; canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration [GO:0044328]; canonical Wnt signaling pathway involved in positive regulation of wound healing [GO:0044330]; cell adhesion [GO:0007155]; gastrulation with mouth forming second [GO:0001702]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of protein phosphorylation [GO:0001933]; phospholipid dephosphorylation [GO:0046839]; phospholipid metabolic process [GO:0006644]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein stabilization [GO:0050821]; regulation of sphingolipid mediated signaling pathway [GO:1902068]; regulation of Wnt signaling pathway [GO:0030111]; single organismal cell-cell adhesion [GO:0016337] GO:0001568; GO:0001702; GO:0001933; GO:0005178; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0006644; GO:0007155; GO:0008195; GO:0016337; GO:0030111; GO:0034109; GO:0042392; GO:0042577; GO:0044328; GO:0044329; GO:0044330; GO:0046839; GO:0050731; GO:0050821; GO:0051091; GO:0060020; GO:0060070; GO:0070062; GO:1902068 0 0 0 PF01569; Q9DCJ9 CHOYP_NPL.3.3 m.29352 sp NPL_MOUSE 44.521 292 151 6 10 294 8 295 4.95E-76 238 NPL_MOUSE reviewed N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) Npl Mus musculus (Mouse) 320 carbohydrate metabolic process [GO:0005975]; N-acetylneuraminate catabolic process [GO:0019262] GO:0005737; GO:0005975; GO:0008747; GO:0019262 PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000269|PubMed:22692205}. 0 0 PF00701; Q9UDX3 CHOYP_SEC14L4.1.1 m.1118 sp S14L4_HUMAN 55.072 138 57 3 44 180 254 387 4.95E-41 146 S14L4_HUMAN reviewed SEC14-like protein 4 (Tocopherol-associated protein 3) SEC14L4 TAP3 Homo sapiens (Human) 406 0 GO:0005215; GO:0005622; GO:0008289; GO:0016021 0 0 0 PF00650; A2ASS6 CHOYP_LOC100169177.1.1 m.2045 sp TITIN_MOUSE 26.714 1269 765 23 1133 2374 6965 8095 4.96E-108 394 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; E1BD59 CHOYP_NEMVEDRAFT_V1G198899.2.3 m.36566 sp TRI56_BOVIN 22.378 286 186 9 8 276 21 287 4.96E-12 69.3 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; F7E235 CHOYP_LOC100377010.7.16 m.37577 sp FAXC_XENTR 33.333 249 154 4 37 275 88 334 4.96E-47 165 FAXC_XENTR reviewed Failed axon connections homolog faxc Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 406 0 GO:0016021 0 0 0 PF17171;PF17172; O15027 CHOYP_LOC588883.2.3 m.14590 sp SC16A_HUMAN 50.905 497 213 10 854 1329 1227 1713 4.96E-144 506 SC16A_HUMAN reviewed Protein transport protein Sec16A (SEC16 homolog A) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) 2179 COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031]; substantia nigra development [GO:0021762] GO:0000139; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0007029; GO:0015031; GO:0021762; GO:0048208 0 0 0 PF12932;PF12931; O36022 CHOYP_ACLA_093460.1.1 m.41459 sp MNN9_SCHPO 35.897 273 156 9 132 391 68 334 4.96E-39 145 MNN9_SCHPO reviewed Mannan polymerase complex subunit mnn9 mnn9 SPAC4F10.10c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 337 negative regulation of G0 to G1 transition [GO:0070317]; protein glycosylation [GO:0006486] GO:0000139; GO:0005783; GO:0005789; GO:0005794; GO:0006486; GO:0016021; GO:0070317 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P39107}. 0 0 0 P18910 CHOYP_OLGC8.1.1 m.30299 sp ANPRA_RAT 44.771 612 303 12 231 828 460 1050 4.96E-157 493 ANPRA_RAT reviewed Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A) Npr1 Rattus norvegicus (Rat) 1057 cell surface receptor signaling pathway [GO:0007166]; cGMP biosynthetic process [GO:0006182]; dopamine metabolic process [GO:0042417]; intracellular signal transduction [GO:0035556]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cGMP biosynthetic process [GO:0030828]; receptor guanylyl cyclase signaling pathway [GO:0007168]; regulation of blood vessel size [GO:0050880] GO:0004383; GO:0004672; GO:0005524; GO:0005525; GO:0005886; GO:0006182; GO:0007166; GO:0007168; GO:0008074; GO:0016021; GO:0016941; GO:0017046; GO:0019901; GO:0030828; GO:0035556; GO:0042417; GO:0043235; GO:0048662; GO:0050880 0 0 0 PF01094;PF00211;PF07714; P19477 CHOYP_FGL1.2.6 m.36672 sp FIBA_PARPA 46.465 198 101 2 351 545 69 264 4.96E-49 174 FIBA_PARPA reviewed Fibrinogen-like protein A (FREP-A) 0 Parastichopus parvimensis (Warty sea cucumber) (Stichopus parvimensis) 282 0 0 0 0 0 PF00147; Q0E908 CHOYP_LOC100903712.1.1 m.26745 sp HIL_DROME 34.356 163 67 6 296 420 11 171 4.96E-16 84.3 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q12800 CHOYP_TFCP2.1.2 m.11029 sp TFCP2_HUMAN 48.491 530 191 12 57 545 14 502 4.96E-166 483 TFCP2_HUMAN reviewed Alpha-globin transcription factor CP2 (SAA3 enhancer factor) (Transcription factor LSF) TFCP2 LSF SEF Homo sapiens (Human) 502 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0008022; GO:0043565 0 0 0 PF04516; Q13310 CHOYP_PABPA.1.1 m.48960 sp PABP4_HUMAN 59.184 245 59 5 6 241 257 469 4.96E-86 276 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q4R6W9 CHOYP_LOC100373005.1.1 m.8832 sp SNPC1_MACFA 36.066 305 175 4 14 314 6 294 4.96E-57 195 SNPC1_MACFA reviewed snRNA-activating protein complex subunit 1 (SNAPc subunit 1) (Small nuclear RNA-activating complex polypeptide 1) (snRNA-activating protein complex 43 kDa subunit) (SNAPc 43 kDa subunit) SNAPC1 QtsA-16981 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 367 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF09808; Q5R5R3 CHOYP_WU_FA11C10.1.1 m.49687 sp F110B_PONAB 25.783 415 219 10 6 402 20 363 4.96E-11 67.4 F110B_PONAB reviewed Protein FAM110B FAM110B Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 370 0 GO:0005739; GO:0005815 0 0 0 PF14160;PF14161; Q5RFT1 CHOYP_BRAFLDRAFT_74627.1.1 m.29264 sp S35F6_PONAB 35.593 413 216 10 8 416 1 367 4.96E-71 231 S35F6_PONAB reviewed Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) SLC35F6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 371 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell proliferation [GO:0008284] GO:0005739; GO:0005765; GO:0008284; GO:0016021; GO:1901029 0 0 0 PF06027; Q80TC5 CHOYP_LOC100560153.1.3 m.9527 sp POGK_MOUSE 37.5 128 76 3 454 578 197 323 4.96E-15 82.4 POGK_MOUSE reviewed Pogo transposable element with KRAB domain Pogk Kiaa1513 Mus musculus (Mouse) 607 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q80TZ9 CHOYP_RERE.1.1 m.15562 sp RERE_MOUSE 46.875 640 248 14 94 651 93 722 4.96E-163 535 RERE_MOUSE reviewed Arginine-glutamic acid dipeptide repeats protein (Atrophin-2) Rere Atr2 Kiaa0458 Mus musculus (Mouse) 1558 branching morphogenesis of a nerve [GO:0048755]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell layer maturation [GO:0021691]; cerebellum development [GO:0021549]; chromatin remodeling [GO:0006338]; dendrite morphogenesis [GO:0048813]; radial glia guided migration of Purkinje cell [GO:0021942] GO:0000118; GO:0001105; GO:0001106; GO:0003682; GO:0003700; GO:0005634; GO:0006338; GO:0008270; GO:0016605; GO:0021549; GO:0021691; GO:0021930; GO:0021942; GO:0043565; GO:0048755; GO:0048813 0 0 0 PF03154;PF01426;PF01448;PF00320; Q8C0L6 CHOYP_SMOX.2.2 m.54286 sp PAOX_MOUSE 33.066 499 291 13 8 470 8 499 4.96E-79 257 PAOX_MOUSE reviewed Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) Paox Pao Mus musculus (Mouse) 504 polyamine catabolic process [GO:0006598]; positive regulation of spermidine biosynthetic process [GO:1901307]; putrescine biosynthetic process [GO:0009446]; putrescine catabolic process [GO:0009447]; spermidine catabolic process [GO:0046203]; spermine catabolic process [GO:0046208] GO:0005102; GO:0005782; GO:0006598; GO:0009446; GO:0009447; GO:0046203; GO:0046208; GO:0046592; GO:0052899; GO:0052901; GO:0052902; GO:0052903; GO:0052904; GO:1901307 PATHWAY: Amine and polyamine metabolism; spermine metabolism. 0 0 PF01593; Q8CEE7 CHOYP_RDH13.2.3 m.27035 sp RDH13_MOUSE 51.333 300 141 3 11 306 9 307 4.96E-92 279 RDH13_MOUSE reviewed Retinol dehydrogenase 13 (EC 1.1.1.-) Rdh13 Mus musculus (Mouse) 334 eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842] GO:0005739; GO:0009644; GO:0010842; GO:0016491; GO:0042462 0 0 0 PF00106; Q8TDY8 CHOYP_DOME.1.2 m.55746 sp IGDC4_HUMAN 25.095 263 160 11 50 295 424 666 4.96E-06 52 IGDC4_HUMAN reviewed Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36) IGDCC4 DDM36 KIAA1628 NOPE Homo sapiens (Human) 1250 0 GO:0005886; GO:0016021 0 0 0 PF00041;PF07679; Q8WZ42 CHOYP_HMCN1.5.44 m.7236 sp TITIN_HUMAN 25.384 2994 1875 125 253 3157 6437 9160 4.96E-137 490 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q96AE4 CHOYP_BRAFLDRAFT_124476.2.4 m.11927 sp FUBP1_HUMAN 57.225 173 69 2 12 184 176 343 4.96E-55 188 FUBP1_HUMAN reviewed Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V) FUBP1 Homo sapiens (Human) 644 positive regulation of gene expression [GO:0010628]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003697; GO:0003700; GO:0005634; GO:0005654; GO:0006366; GO:0010628; GO:0044822 0 0 0 PF09005;PF00013; Q96QU1 CHOYP_BRAFLDRAFT_84111.1.1 m.29331 sp PCD15_HUMAN 30.474 443 252 18 40 461 615 1022 4.96E-30 132 PCD15_HUMAN reviewed Protocadherin-15 PCDH15 USH1F Homo sapiens (Human) 1955 equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear development [GO:0048839]; photoreceptor cell maintenance [GO:0045494]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0001750; GO:0005509; GO:0005615; GO:0005886; GO:0007156; GO:0007605; GO:0016021; GO:0032420; GO:0045202; GO:0045494; GO:0048839; GO:0050953; GO:0050957; GO:0070062 0 0 0 PF00028; Q99M80 CHOYP_LOC100635116.3.5 m.23692 sp PTPRT_MOUSE 34.848 396 241 8 28 416 770 1155 4.96E-59 219 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BDB7 CHOYP_SI_CH211-197G15.10.7.7 m.63889 sp IF44L_MOUSE 30.108 279 153 9 51 323 26 268 4.96E-19 90.9 IF44L_MOUSE reviewed Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) 447 immune response [GO:0006955] GO:0005654; GO:0005737; GO:0006955 0 0 0 0 Q9U8W7 CHOYP_LOC100003029.1.1 m.19633 sp TL5B_TACTR 42.593 162 81 4 2 158 128 282 4.96E-37 133 TL5B_TACTR reviewed Techylectin-5B 0 Tachypleus tridentatus (Japanese horseshoe crab) 316 single organismal cell-cell adhesion [GO:0016337] GO:0005576; GO:0016337; GO:0030246; GO:0046872 0 0 0 PF00147; Q9ULJ7 CHOYP_LOC753709.25.44 m.42021 sp ANR50_HUMAN 31.081 666 371 26 885 1524 500 1103 4.96E-50 199 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; O15014 CHOYP_ZN609.1.1 m.44387 sp ZN609_HUMAN 45.392 293 109 13 160 414 282 561 4.97E-55 214 ZN609_HUMAN reviewed Zinc finger protein 609 ZNF609 KIAA0295 Homo sapiens (Human) 1411 0 GO:0005634; GO:0046872 0 0 0 0 O44252 CHOYP_NEMVEDRAFT_V1G181794.1.1 m.6796 sp ROST_DROME 26.154 260 170 8 11 258 12 261 4.97E-20 90.1 ROST_DROME reviewed Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) 275 myoblast fusion [GO:0007520]; skeletal muscle tissue development [GO:0007519] GO:0007519; GO:0007520; GO:0016020; GO:0016021 0 0 0 0 Q2QI47 CHOYP_RTKX.1.1 m.36711 sp USH2A_MOUSE 25.235 531 284 24 226 662 264 775 4.97E-31 137 USH2A_MOUSE reviewed Usherin (Usher syndrome type IIa protein homolog) (Usher syndrome type-2A protein homolog) Ush2A Gm676 Mus musculus (Mouse) 5193 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002141; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0042803; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF00054;PF02210;PF00055; Q3TBT3 CHOYP_TMEM173.1.5 m.23223 sp STING_MOUSE 43.939 66 37 0 47 112 256 321 4.97E-13 67.8 STING_MOUSE reviewed Stimulator of interferon genes protein (mSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (MMITA) (Transmembrane protein 173) Tmem173 Eris Mita Mpys Sting Mus musculus (Mouse) 378 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0006915; GO:0008134; GO:0016021; GO:0019901; GO:0031625; GO:0032092; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042802; GO:0042803; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; Q5VST9 CHOYP_LOC101063467.1.1 m.7704 sp OBSCN_HUMAN 36.875 160 98 3 6 165 3645 3801 4.97E-18 92.8 OBSCN_HUMAN reviewed Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) OBSCN KIAA1556 KIAA1639 Homo sapiens (Human) 7968 mitophagy in response to mitochondrial depolarization [GO:0098779]; multicellular organism development [GO:0007275]; positive regulation of apoptotic process [GO:0043065]; protein localization to M-band [GO:0036309]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; sarcomere organization [GO:0045214] GO:0004674; GO:0005085; GO:0005089; GO:0005524; GO:0005829; GO:0007275; GO:0008307; GO:0030016; GO:0030018; GO:0030506; GO:0031430; GO:0031432; GO:0035023; GO:0036309; GO:0043065; GO:0045214; GO:0046872; GO:0051056; GO:0098779 0 0 0 PF00041;PF07679;PF00612;PF00069;PF00621; Q5XGC9 CHOYP_SRFB1.1.2 m.18320 sp SRFB1_XENTR 44.037 109 60 1 70 178 4 111 4.97E-21 100 SRFB1_XENTR reviewed Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) srfbp1 TTpA001g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 535 "maturation of SSU-rRNA [GO:0030490]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0030490; GO:0030686; GO:0048471 0 0 0 PF09073; Q67E00 CHOYP_BRAFLDRAFT_81321.9.10 m.56521 sp DUSTY_XENTR 29.67 273 159 9 649 920 648 888 4.97E-21 103 DUSTY_XENTR reviewed Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (Receptor-interacting serine/threonine-protein kinase 5) dstyk ripk5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 918 embryonic organ development [GO:0048568]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0004674; GO:0004712; GO:0004713; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0016323; GO:0016324; GO:0030054; GO:0035556; GO:0048568 0 0 0 PF07714; Q6PBF0 CHOYP_RL8.9.10 m.59751 sp RL8_XENTR 84.27 178 28 0 14 191 31 208 4.97E-113 325 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q8NFZ8 CHOYP_LOC763963.1.1 m.48482 sp CADM4_HUMAN 27.273 242 150 12 100 337 76 295 4.97E-10 64.7 CADM4_HUMAN reviewed Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) CADM4 IGSF4C NECL4 TSLL2 Homo sapiens (Human) 388 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0042803; GO:0050839; GO:0070062 0 0 0 PF08205;PF07686; Q8TD84 CHOYP_SDK.1.1 m.34636 sp DSCL1_HUMAN 27.468 233 154 8 252 475 559 785 4.97E-09 64.3 DSCL1_HUMAN reviewed Down syndrome cell adhesion molecule-like protein 1 (Down syndrome cell adhesion molecule 2) DSCAML1 DSCAM2 KIAA1132 Homo sapiens (Human) 2053 axonogenesis [GO:0007409]; brain development [GO:0007420]; cell fate determination [GO:0001709]; central nervous system development [GO:0007417]; dorsal/ventral pattern formation [GO:0009953]; embryonic skeletal system morphogenesis [GO:0048704]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0001709; GO:0005615; GO:0005886; GO:0007156; GO:0007409; GO:0007417; GO:0007420; GO:0009953; GO:0009986; GO:0016021; GO:0030054; GO:0042803; GO:0045202; GO:0048704 0 0 0 PF00041;PF07679; Q8VDM6 CHOYP_LOC100553519.1.1 m.20707 sp HNRL1_MOUSE 46.04 404 203 8 274 670 210 605 4.97E-115 383 HNRL1_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein U-like protein 1 Hnrnpul1 Hnrpul1 Mus musculus (Mouse) 859 "regulation of transcription, DNA-templated [GO:0006355]; response to virus [GO:0009615]; RNA processing [GO:0006396]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0006396; GO:0009615; GO:0019899; GO:0030529; GO:0044822 0 0 0 PF02037;PF00622; Q9H116 CHOYP_GZF1.2.2 m.33308 sp GZF1_HUMAN 38.976 254 143 8 370 618 362 608 4.97E-43 170 GZF1_HUMAN reviewed GDNF-inducible zinc finger protein 1 (Zinc finger and BTB domain-containing protein 23) (Zinc finger protein 336) GZF1 ZBTB23 ZNF336 Homo sapiens (Human) 711 "branching involved in ureteric bud morphogenesis [GO:0001658]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000978; GO:0000980; GO:0001078; GO:0001206; GO:0001658; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0006351; GO:0043565; GO:0045892; GO:0046872 0 0 0 PF00651;PF13912; Q9H1J7 CHOYP_WNT5A.1.1 m.10293 sp WNT5B_HUMAN 63.529 340 118 3 32 371 26 359 4.97E-161 458 WNT5B_HUMAN reviewed Protein Wnt-5b WNT5B Homo sapiens (Human) 359 cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; fat cell differentiation [GO:0045444]; lens fiber cell development [GO:0070307]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of fat cell differentiation [GO:0045600]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060] GO:0002062; GO:0005102; GO:0005109; GO:0005576; GO:0005578; GO:0005615; GO:0005788; GO:0005796; GO:0005886; GO:0009986; GO:0016055; GO:0030182; GO:0030335; GO:0030666; GO:0042060; GO:0045165; GO:0045444; GO:0045600; GO:0070062; GO:0070307; GO:0071300; GO:0090090 0 0 0 PF00110; Q9QX82 CHOYP_BRAFLDRAFT_63486.1.1 m.39644 sp MUC24_RAT 44.318 88 35 3 241 317 111 195 4.97E-10 61.6 MUC24_RAT reviewed Sialomucin core protein 24 (MUC-24) (Endolyn) (Multi-glycosylated core protein 24) (MGC-24) (MGC-24v) Cd164 Rattus norvegicus (Rat) 195 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; muscle organ development [GO:0007517] GO:0005764; GO:0005765; GO:0005768; GO:0005886; GO:0007157; GO:0007517; GO:0010008; GO:0016021 0 0 0 PF05283; Q9R1R2 CHOYP_BRAFLDRAFT_71598.3.10 m.20497 sp TRIM3_MOUSE 26.282 156 102 5 261 408 593 743 4.97E-08 60.1 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9WUU8 CHOYP_TVAG_198570.5.8 m.51110 sp TNIP1_MOUSE 25.128 195 124 3 381 560 335 522 4.97E-07 57 TNIP1_MOUSE reviewed TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN) (ABIN-1) (Nef-associated factor 1) (Naf1) (Virion-associated nuclear shuttling protein) (VAN) (mVAN) Tnip1 Abin Naf1 Mus musculus (Mouse) 647 glycoprotein biosynthetic process [GO:0009101]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [GO:0085032]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; positive regulation of inflammatory response [GO:0050729]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteolysis [GO:0006508] GO:0002755; GO:0005654; GO:0005737; GO:0006508; GO:0006954; GO:0007159; GO:0009101; GO:0031593; GO:0043124; GO:0045944; GO:0050729; GO:0051019; GO:0070373; GO:0085032 0 0 0 0 B0BNE2 CHOYP_RPAB1.1.1 m.11586 sp RPAB1_RAT 86.603 209 28 0 1 209 1 209 4.98E-136 382 RPAB1_RAT reviewed "DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog)" Polr2e Rattus norvegicus (Rat) 210 transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase II promoter [GO:0006366]; transcription from RNA polymerase I promoter [GO:0006360] GO:0003677; GO:0003899; GO:0005634; GO:0005665; GO:0005666; GO:0005736; GO:0006360; GO:0006366; GO:0006383 0 0 0 PF01191;PF03871; B3EWY9 CHOYP_BRAFLDRAFT_129967.3.4 m.41916 sp MLP_ACRMI 27.281 1162 728 43 492 1607 266 1356 4.98E-98 355 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O43543 CHOYP_TXN4A.2.2 m.59595 sp XRCC2_HUMAN 37.736 212 110 3 49 257 61 253 4.98E-41 145 XRCC2_HUMAN reviewed DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) XRCC2 Homo sapiens (Human) 280 centrosome organization [GO:0051297]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via homologous recombination [GO:0000724]; in utero embryonic development [GO:0001701]; meiotic DNA recombinase assembly [GO:0000707]; meiotic nuclear division [GO:0007126]; mitotic cell cycle [GO:0000278]; mitotic recombination [GO:0006312]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of neurogenesis [GO:0050769]; reciprocal meiotic recombination [GO:0007131]; regulation of fibroblast apoptotic process [GO:2000269]; response to gamma radiation [GO:0010332]; response to ionizing radiation [GO:0010212]; response to X-ray [GO:0010165]; somitogenesis [GO:0001756]; strand displacement [GO:0000732]; strand invasion [GO:0042148] GO:0000150; GO:0000278; GO:0000707; GO:0000724; GO:0000731; GO:0000732; GO:0001701; GO:0001756; GO:0003690; GO:0003697; GO:0005524; GO:0005654; GO:0005657; GO:0005737; GO:0005813; GO:0006281; GO:0006312; GO:0007126; GO:0007131; GO:0008094; GO:0010165; GO:0010212; GO:0010332; GO:0033063; GO:0035264; GO:0042148; GO:0043524; GO:0050769; GO:0051297; GO:2000269 0 0 0 PF08423; O70277 CHOYP_LOC100374741.51.83 m.47072 sp TRIM3_RAT 24.603 252 169 10 277 517 465 706 4.98E-09 62.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P08575 CHOYP_PTPRC.9.14 m.42352 sp PTPRC_HUMAN 27.027 111 68 2 38 136 1115 1224 4.98E-07 51.6 PTPRC_HUMAN reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) PTPRC CD45 Homo sapiens (Human) 1304 B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; hematopoietic progenitor cell differentiation [GO:0002244]; immunoglobulin biosynthetic process [GO:0002378]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell proliferation [GO:0042102]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; release of sequestered calcium ion into cytosol [GO:0051209]; stem cell development [GO:0048864]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] GO:0001915; GO:0001960; GO:0002244; GO:0002378; GO:0004725; GO:0005001; GO:0005886; GO:0005887; GO:0005925; GO:0006469; GO:0006470; GO:0006933; GO:0007166; GO:0009897; GO:0009986; GO:0016020; GO:0016311; GO:0019901; GO:0030217; GO:0030890; GO:0042100; GO:0042102; GO:0044770; GO:0045121; GO:0045860; GO:0048539; GO:0048864; GO:0050852; GO:0050853; GO:0050857; GO:0051209; GO:0051607; GO:0051726; GO:0070062; GO:2000473; GO:2000648 0 0 0 PF12567;PF00041;PF12453;PF00102; P21329 CHOYP_LOC752194.6.12 m.31901 sp RTJK_DROFU 26.859 417 283 10 52 459 436 839 4.98E-35 144 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P23469 CHOYP_PTPRE.10.19 m.41706 sp PTPRE_HUMAN 31.059 557 335 13 9 532 159 699 4.98E-71 243 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P54985 CHOYP_PLIM_3654.1.1 m.18323 sp PPIA_BLAGE 80.921 152 29 0 39 190 1 152 4.98E-88 259 PPIA_BLAGE reviewed Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) CYPA Blattella germanica (German cockroach) (Blatta germanica) 164 protein folding [GO:0006457] GO:0003755; GO:0005737; GO:0006457; GO:0042277 0 0 0 PF00160; P97278 CHOYP_BRAFLDRAFT_92398.2.2 m.22020 sp ITIH1_MESAU 25.85 147 91 3 144 286 296 428 4.98E-06 53.5 ITIH1_MESAU reviewed Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) ITIH1 Mesocricetus auratus (Golden hamster) 914 hyaluronan metabolic process [GO:0030212] GO:0004867; GO:0005576; GO:0030212 0 0 0 PF06668;PF08487;PF00092; P98160 CHOYP_HMCN1.43.44 m.66933 sp PGBM_HUMAN 26.17 577 352 21 15 557 2861 3397 4.98E-31 136 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; Q1L8Y7 CHOYP_TOLL4.1.1 m.22510 sp SHOC2_DANRE 24.731 186 113 6 32 204 298 469 4.98E-07 55.8 SHOC2_DANRE reviewed Leucine-rich repeat protein SHOC-2 (Protein soc-2 homolog) (Protein sur-8 homolog) shoc2 si:ch211-159c12.3 si:ch211-197i12.3 Danio rerio (Zebrafish) (Brachydanio rerio) 561 positive regulation of Ras protein signal transduction [GO:0046579] GO:0000164; GO:0005634; GO:0005737; GO:0019903; GO:0046579 0 0 0 PF13855; Q297V5 CHOYP_LOC100891466.9.10 m.54778 sp KMT5A_DROPS 33.824 68 44 1 10 77 612 678 4.98E-07 51.6 KMT5A_DROPS reviewed Histone-lysine N-methyltransferase pr-set7 (EC 2.1.1.43) (PR/SET domain-containing protein 07) pr-set7 GA17259 Drosophila pseudoobscura pseudoobscura (Fruit fly) 691 "cell division [GO:0051301]; histone methylation [GO:0016571]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005700; GO:0006351; GO:0006355; GO:0007067; GO:0016571; GO:0042799; GO:0051301 0 0 0 PF00856; Q2UTP0 CHOYP_PIGZ.1.2 m.1672 sp SMP3_ASPOR 33.465 254 131 6 25 266 231 458 4.98E-30 122 SMP3_ASPOR reviewed GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) smp3 AO090009000654 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) 543 GPI anchor biosynthetic process [GO:0006506] GO:0005789; GO:0006506; GO:0016021; GO:0016757 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF03901; Q4R3D4 CHOYP_BRAFLDRAFT_198650.1.1 m.30512 sp EF1D_MACFA 55.556 234 84 5 2 220 53 281 4.98E-71 221 EF1D_MACFA reviewed Elongation factor 1-delta (EF-1-delta) EEF1D QthA-21064 QtsA-17735 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 281 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003746; GO:0005634; GO:0005853; GO:0006351; GO:0006355 0 0 cd00292; PF10587;PF00736; Q502K3 CHOYP_TVAG_166520.2.2 m.59111 sp ANR52_DANRE 23.947 380 249 8 17 386 42 391 4.98E-19 97.1 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q61830 CHOYP_LOC588996.1.1 m.33672 sp MRC1_MOUSE 25.18 139 100 3 30 166 670 806 4.98E-08 57.8 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q6P2W5 CHOYP_BRAFLDRAFT_120154.2.2 m.53980 sp ARGL1_XENTR 60.656 183 54 3 1 169 1 179 4.98E-26 103 ARGL1_XENTR reviewed Arginine and glutamate-rich protein 1 arglu1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 265 0 0 0 0 0 PF15346; Q8BLD6 CHOYP_LOC582142.1.1 m.38561 sp ANR55_MOUSE 51.5 200 97 0 30 229 30 229 4.98E-63 209 ANR55_MOUSE reviewed Ankyrin repeat domain-containing protein 55 Ankrd55 Mus musculus (Mouse) 626 0 0 0 0 0 PF12796; Q8IWW6 CHOYP_contig_043284 m.49994 sp RHG12_HUMAN 41.667 60 30 3 30 88 21 76 4.98E-06 49.7 RHG12_HUMAN reviewed Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) ARHGAP12 Homo sapiens (Human) 846 morphogenesis of an epithelial sheet [GO:0002011]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0002011; GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00169;PF00620;PF14604; Q9BXM0 CHOYP_contig_038486 m.43547 sp PRAX_HUMAN 35.156 128 69 5 132 249 582 705 4.98E-15 79 PRAX_HUMAN reviewed Periaxin PRX KIAA1620 Homo sapiens (Human) 1461 axon ensheathment [GO:0008366]; nerve development [GO:0021675] GO:0005634; GO:0005737; GO:0005886; GO:0008366; GO:0021675; GO:0030054; GO:0043209 0 0 0 0 Q9BYN0 CHOYP_BRAFLDRAFT_280480.1.1 m.55076 sp SRXN1_HUMAN 68.056 72 21 1 36 107 29 98 4.98E-29 104 SRXN1_HUMAN reviewed Sulfiredoxin-1 (EC 1.8.98.2) SRXN1 C20orf139 SRX Homo sapiens (Human) 137 response to oxidative stress [GO:0006979] GO:0005524; GO:0005829; GO:0006979; GO:0016667; GO:0032542 0 0 0 PF02195; Q9EQS9 CHOYP_CELAL_3120.1.1 m.22456 sp IGDC4_MOUSE 23.698 384 215 19 80 425 539 882 4.98E-10 66.2 IGDC4_MOUSE reviewed Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) Igdcc4 Ddm36 Kiaa1628 Nope Mus musculus (Mouse) 1252 0 GO:0005887 0 0 0 PF00041;PF07679; Q9ESB5 CHOYP_NECA3.1.1 m.106 sp NECA1_RAT 35.714 336 192 6 1 321 24 350 4.98E-66 214 NECA1_RAT reviewed N-terminal EF-hand calcium-binding protein 1 (EF-hand calcium-binding protein 1) (Neuronal calcium-binding protein 1) (Synaptotagmin-interacting protein 1) (Stip-1) Necab1 Efcbp1 Stip Rattus norvegicus (Rat) 352 0 GO:0005509; GO:0005654; GO:0005737 0 0 0 PF03992;PF13833; Q9PWF7 CHOYP_CATA.2.3 m.18456 sp CATA_RUGRU 62 150 56 1 1 150 350 498 4.98E-58 192 CATA_RUGRU reviewed Catalase (EC 1.11.1.6) cat Rugosa rugosa (Japanese wrinkled frog) (Glandirana rugosa) 528 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004096; GO:0005777; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF00199;PF06628; Q9WUN2 CHOYP_TBK1.1.5 m.34578 sp TBK1_MOUSE 35.714 644 361 11 10 638 2 607 4.98E-123 390 TBK1_MOUSE reviewed Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1) Tbk1 Mus musculus (Mouse) 729 activation of innate immune response [GO:0002218]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; dendritic cell proliferation [GO:0044565]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of xenophagy [GO:1904417] GO:0002218; GO:0003676; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0010629; GO:0018105; GO:0032727; GO:0032728; GO:0043123; GO:0044565; GO:0045087; GO:0045359; GO:0045944; GO:0050830; GO:0051219; GO:0051607; GO:1904417 0 0 0 PF00069; Q9WYG0 CHOYP_PHUM_PHUM411900.1.1 m.50272 sp Y325_THEMA 37.751 249 142 5 822 1067 13 251 4.98E-36 140 Y325_THEMA reviewed Uncharacterized oxidoreductase TM_0325 (EC 1.-.-.-) TM_0325 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) 251 0 GO:0016491 0 0 0 0 B0G143 CHOYP_LOC100368913.1.1 m.25628 sp UCPB_DICDI 49.175 303 133 6 11 310 10 294 4.99E-100 298 UCPB_DICDI reviewed Mitochondrial substrate carrier family protein ucpB (Solute carrier family 25 member 30 homolog) (Uncoupler protein B) ucpB slc25a30 DDB_G0283333 Dictyostelium discoideum (Slime mold) 294 mitochondrial transport [GO:0006839]; translation [GO:0006412] GO:0003735; GO:0005743; GO:0006412; GO:0006839; GO:0016021 0 0 0 PF00153; B3FL73 CHOYP_FBXL3.1.1 m.43665 sp FXL21_SHEEP 25 320 201 12 8 323 41 325 4.99E-09 61.6 FXL21_SHEEP reviewed F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) Fbxl21 Ovis aries (Sheep) 434 entrainment of circadian clock by photoperiod [GO:0043153]; protein ubiquitination [GO:0016567]; rhythmic process [GO:0048511] GO:0005634; GO:0005829; GO:0016567; GO:0019005; GO:0043153; GO:0048511 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; I3LM39 CHOYP_CGAS.2.6 m.22096 sp CGAS_PIG 27.273 209 122 8 242 425 263 466 4.99E-11 69.7 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O60232 CHOYP_SSSCA1.1.2 m.25666 sp SSA27_HUMAN 47.525 202 92 4 2 202 10 198 4.99E-49 161 SSA27_HUMAN reviewed Sjoegren syndrome/scleroderma autoantigen 1 (Autoantigen p27) SSSCA1 Homo sapiens (Human) 199 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0007067; GO:0051301 0 0 0 PF06677; O60462 CHOYP_NRP2.1.8 m.1464 sp NRP2_HUMAN 29.114 237 139 11 70 293 45 265 4.99E-18 91.3 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O95149 CHOYP_LOC101077787.3.3 m.65988 sp SPN1_HUMAN 45.013 371 189 7 1 368 1 359 4.99E-103 324 SPN1_HUMAN reviewed Snurportin-1 (RNA U transporter 1) SNUPN RNUT1 SPN1 Homo sapiens (Human) 360 nuclear import [GO:0051170]; protein import into nucleus [GO:0006606]; snRNA import into nucleus [GO:0061015]; spliceosomal snRNP assembly [GO:0000387] GO:0000339; GO:0000387; GO:0005643; GO:0005829; GO:0006606; GO:0008565; GO:0051170; GO:0061015; GO:0070062 0 0 0 PF11538; P04755 CHOYP_LOC100533245.6.6 m.45247 sp ACH3_DROME 52.511 219 94 2 1 219 1 209 4.99E-76 241 ACH3_DROME reviewed Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) nAChRbeta1 Acr64B AcrD ard nAcRbeta-64B CG11348 Drosophila melanogaster (Fruit fly) 521 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P08570 CHOYP_RLA1.11.12 m.38807 sp RLA1_DROME 59.459 111 41 1 4 110 2 112 4.99E-28 101 RLA1_DROME reviewed 60S acidic ribosomal protein P1 (Acidic ribosomal protein RPA2) (RP21C) RpLP1 M(2)21C rp21C RPA2 RpP2 CG4087 Drosophila melanogaster (Fruit fly) 112 cytoplasmic translation [GO:0002181]; positive regulation of protein kinase activity [GO:0045860]; translational elongation [GO:0006414] GO:0002181; GO:0003735; GO:0005840; GO:0006414; GO:0022625; GO:0030295; GO:0030687; GO:0045860; GO:0070180 0 0 0 0 P19217 CHOYP_AAEL_AAEL004557.1.1 m.14043 sp ST1E1_BOVIN 38.06 268 159 4 151 413 26 291 4.99E-56 189 ST1E1_BOVIN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) 295 estrogen metabolic process [GO:0008210] GO:0004304; GO:0005496; GO:0005737; GO:0008210; GO:0050294 0 0 0 PF00685; P23469 CHOYP_PTPRE.8.19 m.40114 sp PTPRE_HUMAN 33.333 597 339 19 503 1062 115 689 4.99E-84 290 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P70684 CHOYP_LOC591898.1.2 m.28918 sp PGDH_CAVPO 40.392 255 146 2 14 263 1 254 4.99E-62 199 PGDH_CAVPO reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) 265 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q03409 CHOYP_contig_001884 m.2052 sp RS25_DICDI 50 50 23 1 28 75 29 78 4.99E-08 50.1 RS25_DICDI reviewed 40S ribosomal protein S25 (S31) rps25 rpgF DDB_G0271148 Dictyostelium discoideum (Slime mold) 110 0 GO:0003723; GO:0005840 0 0 0 PF03297; Q13569 CHOYP_LOC586471.1.1 m.8913 sp TDG_HUMAN 57.917 240 92 4 102 334 95 332 4.99E-82 268 TDG_HUMAN reviewed G/T mismatch-specific thymine DNA glycosylase (EC 3.2.2.29) (Thymine-DNA glycosylase) (hTDG) TDG Homo sapiens (Human) 410 "base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; covalent chromatin modification [GO:0016569]; depyrimidination [GO:0045008]; DNA demethylation [GO:0080111]; embryo development [GO:0009790]; mismatch repair [GO:0006298]; negative regulation of chromatin binding [GO:0035562]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; oxidative DNA demethylation [GO:0035511]; protein sumoylation [GO:0016925]; regulation of gene expression, epigenetic [GO:0040029]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001104; GO:0003684; GO:0003690; GO:0004844; GO:0005634; GO:0005654; GO:0005886; GO:0006284; GO:0006285; GO:0006298; GO:0006351; GO:0008263; GO:0009790; GO:0016569; GO:0016605; GO:0016925; GO:0019104; GO:0030983; GO:0032091; GO:0035511; GO:0035562; GO:0040029; GO:0042803; GO:0043566; GO:0045008; GO:0080111 0 0 0 PF03167; Q4KLQ5 CHOYP_LOC593392.1.1 m.11166 sp WDR76_XENLA 44.842 475 238 12 109 571 116 578 4.99E-120 369 WDR76_XENLA reviewed WD repeat-containing protein 76 wdr76 Xenopus laevis (African clawed frog) 580 cellular response to DNA damage stimulus [GO:0006974] GO:0006974 0 0 0 0 Q5BK43 CHOYP_BRAFLDRAFT_119549.1.1 m.56597 sp ESIP1_RAT 32.381 210 130 5 66 271 24 225 4.99E-12 68.9 ESIP1_RAT reviewed Epithelial-stromal interaction protein 1 Epsti1 Rattus norvegicus (Rat) 314 0 0 0 0 0 0 Q5R875 CHOYP_TMX3.2.2 m.60912 sp TMX3_PONAB 41.045 402 218 10 1 398 10 396 4.99E-102 314 TMX3_PONAB reviewed Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) TMX3 TXNDC10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 454 cell redox homeostasis [GO:0045454] GO:0003756; GO:0005789; GO:0016021; GO:0045454 0 0 0 PF00085; Q5ZML6 CHOYP_LOC655522.1.1 m.54766 sp F210A_CHICK 35.795 176 84 3 64 227 94 252 4.99E-30 117 F210A_CHICK reviewed Protein FAM210A FAM210A RCJMB04_1k21 Gallus gallus (Chicken) 275 0 GO:0005739; GO:0016021 0 0 0 PF06916; Q80T91 CHOYP_LOC100485666.1.1 m.45513 sp MEG11_MOUSE 38.122 181 99 8 1 181 485 652 4.99E-21 96.3 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8BFR5 CHOYP_LOC658895.1.1 m.20262 sp EFTU_MOUSE 57.683 397 162 3 72 466 47 439 4.99E-168 484 EFTU_MOUSE reviewed "Elongation factor Tu, mitochondrial" Tufm Mus musculus (Mouse) 452 mitochondrial translational elongation [GO:0070125]; translational elongation [GO:0006414] GO:0003746; GO:0003924; GO:0005525; GO:0005739; GO:0005743; GO:0006414; GO:0016020; GO:0042645; GO:0043209; GO:0044822; GO:0070062; GO:0070125 0 0 cd03697; PF03144;PF03143; Q8BMN3 CHOYP_CHRNA7.1.1 m.2522 sp ACHB3_MOUSE 28.571 175 122 1 15 189 25 196 4.99E-18 87.8 ACHB3_MOUSE reviewed Neuronal acetylcholine receptor subunit beta-3 Chrnb3 Mus musculus (Mouse) 464 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; protein heterooligomerization [GO:0051291]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008144; GO:0030054; GO:0035094; GO:0042166; GO:0043005; GO:0045211; GO:0051291; GO:0098655 0 0 0 PF02931;PF02932; Q8NFH3 CHOYP_BRAFLDRAFT_281490.1.1 m.53995 sp NUP43_HUMAN 41.91 377 205 5 8 375 5 376 4.99E-99 301 NUP43_HUMAN reviewed Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) NUP43 Homo sapiens (Human) 380 cell division [GO:0051301]; gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; sister chromatid cohesion [GO:0007062]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0000777; GO:0005635; GO:0005829; GO:0006406; GO:0006409; GO:0007062; GO:0007067; GO:0007077; GO:0010827; GO:0015031; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031080; GO:0051301; GO:0075733; GO:1900034 0 0 0 PF00400; Q96HJ9 CHOYP_CG055.1.1 m.63242 sp CG055_HUMAN 43.011 93 51 2 39 129 11 103 4.99E-20 82 CG055_HUMAN reviewed UPF0562 protein C7orf55 C7orf55 HSPC268 Homo sapiens (Human) 113 0 GO:0005739 0 0 0 0 Q99M80 CHOYP_PTPRK.14.20 m.41704 sp PTPRT_MOUSE 29.379 708 461 13 498 1184 764 1453 4.99E-80 292 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9DFQ7 CHOYP_RL24.4.9 m.22154 sp RL24_GILMI 66.242 157 53 0 1 157 1 157 4.99E-65 198 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9W332 CHOYP_CUBN.7.7 m.64347 sp CUBN_DROME 27.239 268 155 13 45 298 520 761 4.99E-12 72.4 CUBN_DROME reviewed Cubilin homolog Cubn CG32702 Drosophila melanogaster (Fruit fly) 3750 nephrocyte filtration [GO:0097206]; protein transport [GO:0015031]; renal protein absorption [GO:0097017] GO:0005509; GO:0005886; GO:0015031; GO:0097017; GO:0097206 0 0 0 PF00431;PF00008;PF07645;PF12661; A0JN53 CHOYP_RPAP1.1.4 m.35285 sp RPAP1_BOVIN 32.899 1152 659 29 18 1099 1 1108 5.00E-154 498 RPAP1_BOVIN reviewed RNA polymerase II-associated protein 1 RPAP1 Bos taurus (Bovine) 1395 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0006366 0 0 0 PF08620;PF08621; A2VDD2 CHOYP_LOC100375714.1.2 m.12488 sp TC1DB_XENLA 39.286 140 82 1 35 174 40 176 5.00E-31 113 TC1DB_XENLA reviewed Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) 176 0 0 0 0 0 PF03645; P0C5E4 CHOYP_BRAFLDRAFT_124749.3.3 m.52956 sp PTPRQ_MOUSE 24.706 425 239 18 314 690 43 434 5.00E-08 60.5 PTPRQ_MOUSE reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Mus musculus (Mouse) 2300 detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; hematopoietic progenitor cell differentiation [GO:0002244]; inner ear morphogenesis [GO:0042472]; neuromuscular process controlling balance [GO:0050885]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598]; vestibular receptor cell morphogenesis [GO:0060116] GO:0002244; GO:0004725; GO:0016021; GO:0032421; GO:0042472; GO:0045598; GO:0046856; GO:0050885; GO:0050910; GO:0060116 0 0 0 PF00041;PF00102; P10394 CHOYP_LOC100636756.2.4 m.28966 sp POL4_DROME 28.286 350 242 4 52 400 894 1235 5.00E-40 157 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P18288 CHOYP_TBA.3.6 m.29935 sp TBAT_ONCMY 86.782 174 23 0 6 179 26 199 5.00E-96 289 TBAT_ONCMY reviewed "Tubulin alpha chain, testis-specific [Cleaved into: Detyrosinated tubulin alpha chain, testis-specific]" 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P40307 CHOYP_PSMB2.1.1 m.62965 sp PSB2_RAT 68.041 194 62 0 7 200 1 194 5.00E-95 278 PSB2_RAT reviewed Proteasome subunit beta type-2 (EC 3.4.25.1) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I) Psmb2 Rattus norvegicus (Rat) 201 proteolysis involved in cellular protein catabolic process [GO:0051603]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243] GO:0004298; GO:0005654; GO:0005737; GO:0005839; GO:0010243; GO:0014070; GO:0016020; GO:0051603; GO:0070062 0 0 0 PF00227; P42674 CHOYP_LOC581452.4.4 m.53370 sp BP10_PARLI 37.344 241 135 5 5 236 89 322 5.00E-35 144 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P83088 CHOYP_ISCW_ISCW004236.1.5 m.7106 sp FUCTC_DROME 31.657 338 190 11 77 380 82 412 5.00E-39 147 FUCTC_DROME reviewed "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) 425 protein glycosylation [GO:0006486] GO:0006486; GO:0008417; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q008S8 CHOYP_LOC100369302.2.3 m.28082 sp ECT2L_HUMAN 45.93 344 184 2 419 762 562 903 5.00E-94 316 ECT2L_HUMAN reviewed Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH) ECT2L C6orf91 LFDH Homo sapiens (Human) 904 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF14252;PF12937;PF00621; Q0R4F1 CHOYP_PODANSG5041.1.1 m.36259 sp PIF1_XENLA 33.333 210 123 6 13 213 432 633 5.00E-21 101 PIF1_XENLA reviewed ATP-dependent DNA helicase PIF1 (EC 3.6.4.12) (DNA repair and recombination helicase PIF1) pif1 Xenopus laevis (African clawed frog) 635 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; mitochondrial genome maintenance [GO:0000002]; telomere maintenance [GO:0000723] GO:0000002; GO:0000723; GO:0003677; GO:0005524; GO:0005634; GO:0005739; GO:0006281; GO:0006310; GO:0043141 0 0 0 PF02689;PF05970; Q12955 CHOYP_TVAG_168010.30.45 m.54520 sp ANK3_HUMAN 32.201 677 426 2 839 1484 87 761 5.00E-99 357 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q13490 CHOYP_TIAP2.9.13 m.53173 sp BIRC2_HUMAN 27.72 386 203 14 185 512 248 615 5.00E-38 150 BIRC2_HUMAN reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 MIHB RNF48 Homo sapiens (Human) 618 "cell surface receptor signaling pathway [GO:0007166]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; NIK/NF-kappaB signaling [GO:0038061]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell proliferation [GO:0042127]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006921; GO:0007166; GO:0007249; GO:0008270; GO:0009898; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0033209; GO:0034121; GO:0035631; GO:0035666; GO:0038061; GO:0039535; GO:0042127; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045088; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0070266; GO:0070424; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000116; GO:2000377 0 0 0 PF00653;PF00619; Q505D1 CHOYP_ANR28.1.3 m.15534 sp ANR28_MOUSE 67.532 308 99 1 17 324 1 307 5.00E-149 450 ANR28_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK) Ankrd28 Mus musculus (Mouse) 1053 0 GO:0005654 0 0 0 PF00023;PF12796; Q6ZRF8 CHOYP_LOC100374974.14.16 m.53361 sp RN207_HUMAN 20.896 201 145 6 1 199 122 310 5.00E-06 52.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q80TS3 CHOYP_LOC100632098.5.13 m.23447 sp AGRL3_MOUSE 35.843 332 180 9 10 314 941 1266 5.00E-50 181 AGRL3_MOUSE reviewed Adhesion G protein-coupled receptor L3 (Latrophilin-3) (Lectomedin-3) Adgrl3 Kiaa0768 Lec3 Lphn3 Mus musculus (Mouse) 1537 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007416; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q80X72 CHOYP_TLR3.2.6 m.33661 sp LRC15_MOUSE 27.34 406 258 14 72 463 40 422 5.00E-15 80.9 LRC15_MOUSE reviewed Leucine-rich repeat-containing protein 15 Lrrc15 Mus musculus (Mouse) 579 cytokine-mediated signaling pathway [GO:0019221]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813] GO:0001968; GO:0004860; GO:0005518; GO:0005737; GO:0006469; GO:0016021; GO:0019221; GO:0030335; GO:0043236; GO:0046426; GO:0046813; GO:0070062; GO:0090005 0 0 0 PF13855; Q86YP4 CHOYP_P66A.1.1 m.22279 sp P66A_HUMAN 39.206 403 155 14 285 611 102 490 5.00E-58 211 P66A_HUMAN reviewed Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A) GATAD2A Homo sapiens (Human) 633 "DNA methylation [GO:0006306]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003700; GO:0005634; GO:0005654; GO:0006306; GO:0006351; GO:0008270; GO:0016581; GO:0016607; GO:0030674; GO:0043565; GO:0045892 0 0 0 PF00320;PF16563; Q9V5L3 CHOYP_CC44.1.1 m.66208 sp C49A1_DROME 30.256 195 114 7 1 176 51 242 5.00E-12 67.8 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; A0JNG4 CHOYP_LOC100547755.1.1 m.39563 sp RN207_BOVIN 24.39 205 136 7 16 218 103 290 5.01E-13 72.4 RN207_BOVIN reviewed RING finger protein 207 RNF207 Bos taurus (Bovine) 556 0 GO:0005737; GO:0008270 0 0 0 PF00643;PF00097; O95428 CHOYP_LOC101162499.1.1 m.47400 sp PPN_HUMAN 34.292 487 274 10 28 514 29 469 5.01E-82 280 PPN_HUMAN reviewed Papilin PAPLN UNQ2420/PRO4977 Homo sapiens (Human) 1278 0 GO:0004222; GO:0004867; GO:0005578; GO:0008270 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; P02553 CHOYP_TBA1.3.9 m.12255 sp TBA_LYTPI 99.281 139 1 0 1 139 23 161 5.01E-100 286 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P34416 CHOYP_LASP1.1.2 m.24516 sp LASP1_CAEEL 45.538 325 130 6 1 281 1 322 5.01E-88 268 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; Q13685 CHOYP_AAMP.1.1 m.13698 sp AAMP_HUMAN 46.61 354 177 2 66 409 81 432 5.01E-113 341 AAMP_HUMAN reviewed Angio-associated migratory cell protein AAMP Homo sapiens (Human) 434 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; positive regulation of endothelial cell migration [GO:0010595]; ribosomal large subunit biogenesis [GO:0042273]; smooth muscle cell migration [GO:0014909] GO:0001525; GO:0005737; GO:0005886; GO:0008201; GO:0009986; GO:0010595; GO:0014909; GO:0015630; GO:0030154; GO:0030687; GO:0042273; GO:0045171; GO:0051082 0 0 0 PF00400; Q59E55 CHOYP_LOC100375168.1.1 m.23641 sp NAB_DROME 44.575 341 164 6 1 319 108 445 5.01E-74 250 NAB_DROME reviewed NGFI-A-binding protein homolog (dNAB) nab CG33545 Drosophila melanogaster (Fruit fly) 625 "cell proliferation [GO:0008283]; locomotory behavior [GO:0007626]; negative regulation of transcription, DNA-templated [GO:0045892]; neuroblast development [GO:0014019]; neuron development [GO:0048666]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; wing disc pattern formation [GO:0035222]" GO:0003712; GO:0005634; GO:0006351; GO:0006355; GO:0007626; GO:0008283; GO:0014019; GO:0035222; GO:0045892; GO:0048666 0 0 0 PF04904;PF04905; Q6DEJ5 CHOYP_BRAFLDRAFT_127497.1.1 m.35445 sp AASD1_DANRE 53.25 400 183 3 14 411 5 402 5.01E-153 442 AASD1_DANRE reviewed Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1) aarsd1 zgc:101066 Danio rerio (Zebrafish) (Brachydanio rerio) 412 regulation of translational fidelity [GO:0006450]; translation [GO:0006412]; tRNA aminoacylation [GO:0043039] GO:0000049; GO:0002196; GO:0005524; GO:0005737; GO:0006412; GO:0006450; GO:0016876; GO:0043039; GO:0046872 0 0 0 PF07973; Q6WYY1 CHOYP_PCDH11Y.1.1 m.43313 sp PC11X_PANPA 31.818 836 516 16 11 803 14 838 5.01E-106 361 PC11X_PANPA reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) PCDH11X PCDH11 PCDHX Pan paniscus (Pygmy chimpanzee) (Bonobo) 1347 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q8BGB5 CHOYP_LIMA1.1.1 m.60094 sp LIMD2_MOUSE 45.556 90 48 1 22 110 17 106 5.01E-22 86.7 LIMD2_MOUSE reviewed LIM domain-containing protein 2 Limd2 Mus musculus (Mouse) 128 0 GO:0008270 0 0 0 PF00412; Q9D2V8 CHOYP_NEMVEDRAFT_V1G177762.1.1 m.18774 sp MFS10_MOUSE 47.872 376 182 3 109 480 52 417 5.01E-119 359 MFS10_MOUSE reviewed Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein) Mfsd10 Tetran Mus musculus (Mouse) 456 apoptotic process [GO:0006915]; sodium-independent organic anion transport [GO:0043252]; tetracycline transport [GO:0015904]; transmembrane transport [GO:0055085] GO:0006915; GO:0008493; GO:0008514; GO:0015904; GO:0016021; GO:0030659; GO:0031526; GO:0043252; GO:0055085 0 0 cd06174; PF07690; Q9H4G4 CHOYP_ISCW_ISCW019177.1.4 m.20846 sp GAPR1_HUMAN 47.826 69 33 2 24 92 9 74 5.01E-12 63.9 GAPR1_HUMAN reviewed Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) 154 positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374 0 0 0 PF00188; Q9H8X2 CHOYP_IPPK.1.2 m.23050 sp IPPK_HUMAN 34.591 159 89 5 15 173 45 188 5.01E-19 86.7 IPPK_HUMAN reviewed "Inositol-pentakisphosphate 2-kinase (EC 2.7.1.158) (IPK1 homolog) (Inositol-1,3,4,5,6-pentakisphosphate 2-kinase) (Ins(1,3,4,5,6)P5 2-kinase) (InsP5 2-kinase)" IPPK C9orf12 Homo sapiens (Human) 491 inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; inositol phosphorylation [GO:0052746]; mitophagy in response to mitochondrial depolarization [GO:0098779] GO:0005524; GO:0005622; GO:0005634; GO:0005654; GO:0005829; GO:0032958; GO:0035299; GO:0043647; GO:0052746; GO:0098779 0 0 0 PF06090; Q9JHI0 CHOYP_MMP1.1.1 m.25613 sp MMP19_MOUSE 31.47 483 289 13 9 484 11 458 5.01E-58 204 MMP19_MOUSE reviewed Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) Mmp19 Rasi Mus musculus (Mouse) 527 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; luteolysis [GO:0001554]; ovarian follicle development [GO:0001541]; ovulation from ovarian follicle [GO:0001542]; response to cAMP [GO:0051591]; response to hormone [GO:0009725] GO:0001525; GO:0001541; GO:0001542; GO:0001554; GO:0004222; GO:0004252; GO:0005509; GO:0005576; GO:0005578; GO:0005886; GO:0008270; GO:0009725; GO:0022617; GO:0030154; GO:0030574; GO:0031225; GO:0051591 0 0 cd04278; PF00045;PF00413;PF01471; Q9LIK5 CHOYP_CALM.28.50 m.37092 sp CML11_ARATH 53.793 145 66 1 3 147 27 170 5.01E-48 155 CML11_ARATH reviewed Calmodulin-like protein 11 CML11 At3g22930 F5N5.10 Arabidopsis thaliana (Mouse-ear cress) 173 0 GO:0005509 0 0 0 PF13499; Q9NRD1 CHOYP_FBX6.1.1 m.62308 sp FBX6_HUMAN 38.846 260 152 5 74 330 16 271 5.01E-59 195 FBX6_HUMAN reviewed F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2) FBXO6 FBG2 FBS2 FBX6 Homo sapiens (Human) 293 DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; glycoprotein catabolic process [GO:0006516]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; response to unfolded protein [GO:0006986]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000077; GO:0000209; GO:0001948; GO:0004842; GO:0005737; GO:0005829; GO:0006281; GO:0006508; GO:0006516; GO:0006986; GO:0019005; GO:0030246; GO:0030433; GO:0031146; GO:0044322; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF04300; B2RTY4 CHOYP_LOC100870108.3.4 m.50445 sp MYO9A_HUMAN 36.364 594 333 17 599 1160 1811 2391 5.02E-98 348 MYO9A_HUMAN reviewed Unconventional myosin-IXa (Unconventional myosin-9a) MYO9A MYR7 Homo sapiens (Human) 2548 intracellular signal transduction [GO:0035556]; regulation of small GTPase mediated signal transduction [GO:0051056]; visual perception [GO:0007601] GO:0003774; GO:0005096; GO:0005524; GO:0005829; GO:0007601; GO:0016021; GO:0016461; GO:0035556; GO:0046872; GO:0051056 0 0 0 PF00612;PF00063;PF00788;PF00620; B3EWZ3 CHOYP_NEMVEDRAFT_V1G33857.1.1 m.30998 sp CADN_ACRMI 39.535 215 110 3 638 835 333 544 5.02E-41 167 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; G5ED84 CHOYP_LOC100575377.7.10 m.38836 sp KLHL8_CAEEL 26.875 160 105 4 10 158 88 246 5.02E-09 63.2 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O75382 CHOYP_BRAFLDRAFT_124722.1.3 m.25734 sp TRIM3_HUMAN 27.273 220 138 9 94 304 536 742 5.02E-09 60.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P37801 CHOYP_SMP_078690.4.5 m.41580 sp CLPH_ONCVO 40.526 190 96 8 100 273 144 332 5.02E-27 111 CLPH_ONCVO reviewed Calponin homolog OV9M 0 Onchocerca volvulus 378 0 0 0 0 0 PF00402; P41900 CHOYP_BRAFLDRAFT_284971.1.1 m.8608 sp T2FB_DROME 47.2 250 127 4 40 288 14 259 5.02E-76 236 T2FB_DROME reviewed General transcription factor IIF subunit 2 (EC 3.6.4.12) (ATP-dependent helicase TfIIF-beta) (Transcription initiation factor IIF subunit beta) (TFIIF-beta) TfIIFbeta TFIIF30 CG6538 Drosophila melanogaster (Fruit fly) 277 positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; transcription initiation from RNA polymerase II promoter [GO:0006367] GO:0000991; GO:0001096; GO:0003677; GO:0004386; GO:0005524; GO:0005634; GO:0005674; GO:0006367; GO:0032968; GO:0045944; GO:0060261 0 0 0 PF02270; P48148 CHOYP_RHO1.3.3 m.44338 sp RHO1_DROME 90.625 192 18 0 1 192 1 192 5.02E-130 365 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; Q14162 CHOYP_MEGF11.9.11 m.60220 sp SREC_HUMAN 35.484 186 113 6 190 375 213 391 5.02E-25 110 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q14BN4 CHOYP_SLMAP.5.8 m.26724 sp SLMAP_HUMAN 39.634 820 398 17 24 794 3 774 5.02E-149 464 SLMAP_HUMAN reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) 828 muscle contraction [GO:0006936] GO:0005790; GO:0005815; GO:0005887; GO:0006936; GO:0042383 0 0 0 PF00498; Q1LV22 CHOYP_FAM214A.1.1 m.16055 sp F214A_DANRE 54.244 271 109 3 769 1029 723 988 5.02E-83 293 F214A_DANRE reviewed Protein FAM214A fam214a si:dkey-266j9.3 Danio rerio (Zebrafish) (Brachydanio rerio) 989 0 0 0 0 0 PF13889;PF13915; Q29RP8 CHOYP_S421A.1.1 m.16724 sp KMT5B_BOVIN 52.812 320 109 7 16 305 55 362 5.02E-104 330 KMT5B_BOVIN reviewed Histone-lysine N-methyltransferase KMT5B (EC 2.1.1.43) (Lysine-specific methyltransferase 5B) (Suppressor of variegation 4-20 homolog 1) (Su(var)4-20 homolog 1) (Suv4-20h1) KMT5B SUV420H1 Bos taurus (Bovine) 393 "histone H4-K20 trimethylation [GO:0034773]; muscle organ development [GO:0007517]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0007517; GO:0018024; GO:0034773; GO:0042799 0 0 0 PF00856; Q4H4B6 CHOYP_SCRIB.1.1 m.6074 sp SCRIB_DANRE 54.753 263 111 2 6 260 997 1259 5.02E-88 295 SCRIB_DANRE reviewed Protein scribble homolog (Scribble1) scrib llk scrb1 Danio rerio (Zebrafish) (Brachydanio rerio) 1724 activation of GTPase activity [GO:0090630]; apoptotic process involved in morphogenesis [GO:0060561]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; convergent extension involved in gastrulation [GO:0060027]; establishment of apical/basal cell polarity [GO:0035089]; establishment of mitotic spindle orientation [GO:0000132]; establishment of planar polarity [GO:0001736]; motor neuron migration [GO:0097475]; negative regulation of mitotic cell cycle [GO:0045930]; neuron migration [GO:0001764]; positive chemotaxis [GO:0050918]; positive regulation of apoptotic process [GO:0043065]; secondary neural tube formation [GO:0014021]; single organismal cell-cell adhesion [GO:0016337]; vasculature development [GO:0001944] GO:0000132; GO:0001736; GO:0001764; GO:0001944; GO:0005737; GO:0005886; GO:0005911; GO:0005913; GO:0008283; GO:0014021; GO:0016020; GO:0016337; GO:0016477; GO:0035089; GO:0043065; GO:0045930; GO:0046982; GO:0050918; GO:0060027; GO:0060561; GO:0090630; GO:0097475 0 0 0 PF13855;PF00595; Q5R8Z6 CHOYP_BRAFLDRAFT_123910.1.1 m.12239 sp MCFD2_PONAB 43.617 94 45 1 56 141 8 101 5.02E-20 84.3 MCFD2_PONAB reviewed Multiple coagulation factor deficiency protein 2 homolog MCFD2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 146 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005509; GO:0005783; GO:0005793; GO:0005794; GO:0015031; GO:0016192 0 0 0 PF13499; Q5R9L9 CHOYP_POMP.1.2 m.51503 sp POMP_PONAB 47.059 119 63 0 37 155 23 141 5.02E-32 114 POMP_PONAB reviewed Proteasome maturation protein (Proteassemblin) POMP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 141 proteasome assembly [GO:0043248] GO:0005634; GO:0005783; GO:0005829; GO:0031090; GO:0043248 0 0 0 0 Q5UAW9 CHOYP_LOC100650648.2.2 m.41489 sp GP157_HUMAN 28.754 313 192 6 17 326 3 287 5.02E-18 87 GP157_HUMAN reviewed Probable G-protein coupled receptor 157 GPR157 Homo sapiens (Human) 335 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021 0 0 0 PF00002; Q6GQQ9 CHOYP_MUC1.4.5 m.58459 sp OTU7B_HUMAN 46.154 78 38 1 1 78 211 284 5.02E-17 78.6 OTU7B_HUMAN reviewed OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) OTUD7B ZA20D1 Homo sapiens (Human) 843 immune response [GO:0006955]; mucosal immune response [GO:0002385]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of protein localization to nucleus [GO:1900181]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536] GO:0000122; GO:0002385; GO:0003677; GO:0004843; GO:0005634; GO:0005737; GO:0006955; GO:0008234; GO:0008270; GO:0032717; GO:0035871; GO:0043124; GO:0070530; GO:0070536; GO:0071108; GO:0071947; GO:1900181; GO:1990380 0 0 0 PF02338;PF01754; Q6ZUJ8 CHOYP_PHUM_PHUM577900.1.1 m.65804 sp BCAP_HUMAN 30.952 168 112 2 210 374 221 387 5.02E-16 84.3 BCAP_HUMAN reviewed Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) PIK3AP1 BCAP Homo sapiens (Human) 805 negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; regulation of inflammatory response [GO:0050727]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162] GO:0005829; GO:0005886; GO:0014068; GO:0016020; GO:0034122; GO:0034123; GO:0034134; GO:0034142; GO:0034154; GO:0034162; GO:0036312; GO:0050727 0 0 0 PF14545; Q92193 CHOYP_ACT.26.27 m.66246 sp ACT_CRAVI 100 46 0 0 48 93 81 126 5.02E-25 98.6 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q99LM2 CHOYP_LOC100377362.1.1 m.10266 sp CK5P3_MOUSE 42.722 529 260 10 1 515 1 500 5.02E-142 421 CK5P3_MOUSE reviewed CDK5 regulatory subunit-associated protein 3 Cdk5rap3 Mus musculus (Mouse) 503 apoptotic nuclear changes [GO:0030262]; cell proliferation [GO:0008283]; endoplasmic reticulum unfolded protein response [GO:0030968]; mitotic G2/M transition checkpoint [GO:0044818]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of cellular protein catabolic process [GO:1903363]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ufmylation [GO:0071569]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of mitotic cell cycle [GO:0007346]; regulation of phosphatase activity [GO:0010921] GO:0000079; GO:0001933; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0007095; GO:0007346; GO:0008283; GO:0010921; GO:0012505; GO:0016020; GO:0019901; GO:0030262; GO:0030332; GO:0030968; GO:0031398; GO:0032088; GO:0043234; GO:0043407; GO:0044387; GO:0044389; GO:0044818; GO:0045944; GO:0051019; GO:0051059; GO:0071569; GO:0071901; GO:0097371; GO:1900182; GO:1901798; GO:1903363 0 0 0 PF05600; Q9GNN8 CHOYP_contig_003852 m.4386 sp CTXA_CARAL 19.231 338 244 13 69 393 120 441 5.02E-06 52 CTXA_CARAL reviewed Toxin CaTX-A (Toxin A) (CAT-1) 0 Carybdea alata (Hawaiian box jellyfish) 463 hemolysis in other organism [GO:0044179]; ion transport [GO:0006811] GO:0005576; GO:0006811; GO:0016021; GO:0042151; GO:0044179; GO:0044218 0 0 0 0 Q9H2S1 CHOYP_LOC657962.1.1 m.36073 sp KCNN2_HUMAN 39.416 411 241 4 62 466 116 524 5.02E-101 317 KCNN2_HUMAN reviewed Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) KCNN2 Homo sapiens (Human) 579 potassium ion transmembrane transport [GO:0071805]; potassium ion transport [GO:0006813]; regulation of potassium ion transmembrane transport [GO:1901379] GO:0005516; GO:0005790; GO:0005886; GO:0006813; GO:0009986; GO:0015269; GO:0016021; GO:0016286; GO:0019904; GO:0030018; GO:0030315; GO:0042803; GO:0043025; GO:0043197; GO:0051393; GO:0071805; GO:1901379 0 0 0 PF02888;PF07885;PF03530; Q9QUS6 CHOYP_LOC100374819.1.7 m.34139 sp TRIM1_MOUSE 27.241 290 159 15 24 283 24 291 5.02E-11 68.6 TRIM1_MOUSE reviewed Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midline defect 2) (Midline-2) (Tripartite motif-containing protein 1) Mid2 Fxy2 Trim1 Mus musculus (Mouse) 705 innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567] GO:0005737; GO:0005874; GO:0008017; GO:0008270; GO:0010508; GO:0016567; GO:0016874; GO:0032897; GO:0035372; GO:0042803; GO:0043123; GO:0045087; GO:0046597; GO:0046982; GO:0051091; GO:0051092; GO:0051219; GO:0070062; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643;PF13445; Q9Y6I7 CHOYP_WSB1.2.2 m.60800 sp WSB1_HUMAN 45.199 427 207 9 17 432 9 419 5.02E-122 364 WSB1_HUMAN reviewed WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1) WSB1 SWIP1 Homo sapiens (Human) 421 intracellular signal transduction [GO:0035556]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005622; GO:0005829; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07525;PF00400; A5D787 CHOYP_LOC100671857.1.1 m.29856 sp M17L2_BOVIN 38.636 176 102 4 9 181 16 188 5.03E-30 112 M17L2_BOVIN reviewed Mpv17-like protein 2 MPV17L2 Bos taurus (Bovine) 218 mitochondrial ribosome assembly [GO:0061668]; positive regulation of mitochondrial translation [GO:0070131] GO:0005743; GO:0005762; GO:0016021; GO:0061668; GO:0070131 0 0 0 PF04117; B4PZ52 CHOYP_LOC100378414.1.1 m.34038 sp NFU1_DROYA 56.827 271 104 4 2 267 8 270 5.03E-107 314 NFU1_DROYA reviewed "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial" GE15286 Drosophila yakuba (Fruit fly) 283 iron-sulfur cluster assembly [GO:0016226] GO:0005506; GO:0005739; GO:0016226; GO:0051536 0 0 0 PF08712;PF01106; O01761 CHOYP_UNC89.17.19 m.58312 sp UNC89_CAEEL 26.636 428 281 21 50 460 3247 3658 5.03E-21 102 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O70277 CHOYP_BRAFLDRAFT_82426.5.20 m.32774 sp TRIM3_RAT 28.333 120 81 3 42 158 627 744 5.03E-07 51.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_71598.4.10 m.20518 sp TRIM3_HUMAN 24.59 122 89 2 296 414 622 743 5.03E-06 52.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P23469 CHOYP_PTPRA.5.22 m.17115 sp PTPRE_HUMAN 27.174 92 66 1 34 124 595 686 5.03E-09 56.2 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P42573 CHOYP_LOC100185724.2.2 m.58677 sp CED3_CAEEL 34.014 147 63 7 253 384 232 359 5.03E-09 62 CED3_CAEEL reviewed Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 C48D1.2 Caenorhabditis elegans 503 apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; embryo development ending in birth or egg hatching [GO:0009792]; execution phase of apoptosis [GO:0097194]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; regulation of apoptotic process [GO:0042981]; regulation of cell adhesion [GO:0030155] GO:0004175; GO:0004197; GO:0005737; GO:0006915; GO:0009792; GO:0012501; GO:0016020; GO:0016540; GO:0030155; GO:0030163; GO:0042802; GO:0042981; GO:0048471; GO:0097194; GO:0097200; GO:1902742 0 0 0 PF00619; Q00PJ1 CHOYP_TVAG_451090.13.13 m.64723 sp CTTB2_ATEAB 36.364 176 106 3 27 196 691 866 5.03E-27 110 CTTB2_ATEAB reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) 1654 0 GO:0005938; GO:0043197 0 0 0 PF12796;PF09727; Q0VFZ6 CHOYP_LOC100372239.1.1 m.50390 sp CC173_HUMAN 37.222 540 300 10 44 568 37 552 5.03E-80 264 CC173_HUMAN reviewed Coiled-coil domain-containing protein 173 CCDC173 C2orf77 Homo sapiens (Human) 552 0 0 0 0 0 0 Q6PAE6 CHOYP_LOC101241753.2.2 m.61286 sp CE022_XENLA 22.026 454 285 15 80 515 13 415 5.03E-09 62 CE022_XENLA reviewed UPF0489 protein C5orf22 homolog 0 Xenopus laevis (African clawed frog) 423 0 0 0 0 0 PF12640; Q6PII3 CHOYP_LOC100541982.1.1 m.62957 sp CC174_HUMAN 44.578 415 197 13 12 411 1 397 5.03E-78 259 CC174_HUMAN reviewed Coiled-coil domain-containing protein 174 CCDC174 C3orf19 Homo sapiens (Human) 467 0 GO:0005654 0 0 0 PF13300; Q8R081 CHOYP_HNRPL.1.1 m.23313 sp HNRPL_MOUSE 66.049 162 55 0 1 162 128 289 5.03E-73 233 HNRPL_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein L (hnRNP L) Hnrnpl Hnrpl Mus musculus (Mouse) 586 "mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000166; GO:0000381; GO:0005634; GO:0005654; GO:0005737; GO:0006397; GO:0016020; GO:0030529; GO:0035770; GO:0044212; GO:0044822; GO:0045120; GO:0070062; GO:0097157 0 0 0 PF00076; Q8VEH0 CHOYP_TM144.1.2 m.14089 sp TM144_MOUSE 45.676 370 159 4 123 483 11 347 5.03E-109 330 TM144_MOUSE reviewed Transmembrane protein 144 Tmem144 Mus musculus (Mouse) 348 0 GO:0016021 0 0 0 PF07857; Q91W78 CHOYP_USB1.1.1 m.35883 sp USB1_MOUSE 38.376 271 151 7 4 268 6 266 5.03E-54 179 USB1_MOUSE reviewed U6 snRNA phosphodiesterase (EC 3.1.4.-) Usb1 Mus musculus (Mouse) 267 mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; U6 snRNA 3'-end processing [GO:0034477] GO:0000175; GO:0005634; GO:0006397; GO:0008380; GO:0034477; GO:0045171 0 0 0 PF09749; Q9D0N7 CHOYP_CHAF1B.1.1 m.46811 sp CAF1B_MOUSE 52.212 452 191 9 24 468 1 434 5.03E-163 479 CAF1B_MOUSE reviewed Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-I p60) Chaf1b Mus musculus (Mouse) 572 "cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nucleosome assembly [GO:0006334]; positive regulation of defense response to virus by host [GO:0002230]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; xenophagy [GO:0098792]" GO:0000790; GO:0002230; GO:0005634; GO:0005654; GO:0005829; GO:0006260; GO:0006281; GO:0006334; GO:0006335; GO:0006351; GO:0006355; GO:0007049; GO:0031497; GO:0033186; GO:0042393; GO:0043234; GO:0098779; GO:0098792 0 0 0 PF15512;PF00400; Q9D4J7 CHOYP_LOC100702129.1.1 m.6180 sp PHF6_MOUSE 42.105 133 56 5 8 136 211 326 5.03E-21 94.4 PHF6_MOUSE reviewed PHD finger protein 6 Phf6 Kiaa1823 Mus musculus (Mouse) 364 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000777; GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0008270; GO:0015631; GO:0019899; GO:0042393; GO:0042826; GO:0043021; GO:0044822; GO:0051219; GO:0097110 0 0 0 0 Q9DC33 CHOYP_BRAFLDRAFT_124005.1.1 m.13274 sp HM20A_MOUSE 39.645 169 89 4 131 294 30 190 5.03E-31 125 HM20A_MOUSE reviewed High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein HMGX1) (Inhibitor of BRAF35) (iBRAF) Hmg20a Ibraf Mus musculus (Mouse) 346 "covalent chromatin modification [GO:0016569]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005634; GO:0006351; GO:0016569; GO:0033234; GO:0045665; GO:0046982 0 0 0 PF00505; Q9H8W5 CHOYP_LOC100369014.4.9 m.34118 sp TRI45_HUMAN 25.068 367 222 14 10 340 20 369 5.03E-17 85.9 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_255103.8.18 m.39280 sp TRIM2_BOVIN 24.342 152 114 1 16 167 593 743 5.04E-08 55.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_79377.17.30 m.39419 sp TRIM2_BOVIN 31.132 106 70 2 223 326 627 731 5.04E-07 54.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15123 CHOYP_LOC100313602.1.2 m.22564 sp ANGP2_HUMAN 35.361 263 146 7 66 313 241 494 5.04E-38 144 ANGP2_HUMAN reviewed Angiopoietin-2 (ANG-2) ANGPT2 Homo sapiens (Human) 496 angiogenesis [GO:0001525]; cellular response to growth factor stimulus [GO:0071363]; germ cell development [GO:0007281]; glomerulus vasculature development [GO:0072012]; leukocyte migration [GO:0050900]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of positive chemotaxis [GO:0050928]; organ regeneration [GO:0031100]; positive regulation of angiogenesis [GO:0045766]; response to activity [GO:0014823]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to radiation [GO:0009314]; signal transduction [GO:0007165]; Tie signaling pathway [GO:0048014] GO:0001525; GO:0001666; GO:0005102; GO:0005576; GO:0005615; GO:0005634; GO:0005886; GO:0007165; GO:0007281; GO:0009314; GO:0009612; GO:0009749; GO:0010812; GO:0014070; GO:0014823; GO:0016525; GO:0030971; GO:0031100; GO:0042995; GO:0043537; GO:0045766; GO:0046872; GO:0048014; GO:0050900; GO:0050928; GO:0060135; GO:0071363; GO:0072012 0 0 0 PF00147; O75382 CHOYP_BRAFLDRAFT_87269.6.8 m.47297 sp TRIM3_HUMAN 22.727 264 174 6 183 427 492 744 5.04E-09 62 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06731 CHOYP_CEAM5.6.6 m.66452 sp CEAM5_HUMAN 26.426 333 191 13 10 337 200 483 5.04E-13 75.1 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; P07451 CHOYP_CAH1.2.2 m.29412 sp CAH3_HUMAN 31.008 258 164 8 310 560 9 259 5.04E-31 124 CAH3_HUMAN reviewed Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonate dehydratase III) (Carbonic anhydrase III) (CA-III) CA3 Homo sapiens (Human) 260 bicarbonate transport [GO:0015701]; one-carbon metabolic process [GO:0006730]; response to ethanol [GO:0045471]; response to oxidative stress [GO:0006979] GO:0004089; GO:0005829; GO:0006730; GO:0006979; GO:0008270; GO:0015701; GO:0016151; GO:0016791; GO:0045471 0 0 0 PF00194; P18172 CHOYP_LOC100877554.2.2 m.34916 sp DHGL_DROPS 40.63 571 296 11 36 594 65 604 5.04E-129 395 DHGL_DROPS reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) 625 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; P33527 CHOYP_MRP1.3.10 m.27615 sp MRP1_HUMAN 58.312 391 161 2 1 390 1142 1531 5.04E-153 472 MRP1_HUMAN reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) ABCC1 MRP MRP1 Homo sapiens (Human) 1531 cobalamin metabolic process [GO:0009235]; leukotriene metabolic process [GO:0006691]; response to drug [GO:0042493]; transmembrane transport [GO:0055085]; transport [GO:0006810] GO:0005215; GO:0005524; GO:0005886; GO:0005887; GO:0006691; GO:0006810; GO:0009235; GO:0015420; GO:0016020; GO:0016323; GO:0016887; GO:0042493; GO:0042626; GO:0043225; GO:0055085; GO:0070062 0 0 0 PF00664;PF00005; P38571 CHOYP_LOC100212698.1.1 m.5807 sp LICH_HUMAN 43.421 380 205 4 17 390 24 399 5.04E-106 320 LICH_HUMAN reviewed Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Lipase A) (Sterol esterase) LIPA Homo sapiens (Human) 399 cell morphogenesis [GO:0000902]; cell proliferation [GO:0008283]; cytokine production [GO:0001816]; fatty acid metabolic process [GO:0006631]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; lung development [GO:0030324]; sterol metabolic process [GO:0016125]; tissue remodeling [GO:0048771] GO:0000902; GO:0001816; GO:0004771; GO:0005764; GO:0006631; GO:0006954; GO:0008283; GO:0016042; GO:0016125; GO:0016298; GO:0030324; GO:0048771; GO:0048873; GO:0070062 0 0 0 PF00561; P46198 CHOYP_MTIF2.1.1 m.17935 sp IF2M_BOVIN 38.102 748 398 13 14 742 24 725 5.04E-160 483 IF2M_BOVIN reviewed "Translation initiation factor IF-2, mitochondrial (IF-2(Mt)) (IF-2Mt) (IF2(mt))" MTIF2 Bos taurus (Bovine) 727 mitochondrial translational initiation [GO:0070124]; ribosome disassembly [GO:0032790] GO:0003743; GO:0003924; GO:0005525; GO:0005654; GO:0005739; GO:0005759; GO:0008135; GO:0032790; GO:0043024; GO:0044822; GO:0070124 0 0 0 PF11987; P49230 CHOYP_INSI2.1.1 m.59456 sp PROF_ENTHI 34 100 65 1 24 122 22 121 5.04E-11 59.3 PROF_ENTHI reviewed Profilin 0 Entamoeba histolytica 130 0 GO:0005737; GO:0005856 0 0 0 PF00235; Q09575 CHOYP_LOC100373153.1.1 m.48215 sp YRD6_CAEEL 21.173 307 179 10 92 378 817 1080 5.04E-06 52.8 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q28ID3 CHOYP_GLRX3.1.1 m.63529 sp GLRX3_XENTR 62.883 326 117 2 15 340 3 324 5.04E-151 431 GLRX3_XENTR reviewed Glutaredoxin-3 (Thioredoxin-like protein 2) glrx3 txnl2 TNeu109g06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 326 cell redox homeostasis [GO:0045454] GO:0005938; GO:0009055; GO:0015035; GO:0045454; GO:0046872; GO:0051536 0 0 cd03028; PF00462;PF00085; Q6DFM9 CHOYP_TOM20.1.1 m.11207 sp TOM20_XENTR 52.096 167 54 3 13 176 4 147 5.04E-43 143 TOM20_XENTR reviewed Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20) tomm20 TNeu065b24.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 147 mitochondrial outer membrane translocase complex assembly [GO:0070096]; protein import into mitochondrial matrix [GO:0030150]; tRNA import into mitochondrion [GO:0016031] GO:0005742; GO:0015450; GO:0016031; GO:0030150; GO:0030943; GO:0031307; GO:0070096 0 0 0 PF02064; Q6DGL7 CHOYP_LOC100370503.1.1 m.59702 sp TM147_DANRE 61.538 221 85 0 14 234 1 221 5.04E-98 288 TM147_DANRE reviewed Transmembrane protein 147 tmem147 zgc:92863 Danio rerio (Zebrafish) (Brachydanio rerio) 225 0 GO:0016020; GO:0016021 0 0 0 PF09767; Q6R7J2 CHOYP_Y028.1.1 m.30882 sp Y031_OSHVF 98.919 185 2 0 1 185 1 185 5.04E-136 380 Y031_OSHVF reviewed Uncharacterized protein ORF31 ORF30 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 185 0 0 0 0 0 0 Q7T3C6 CHOYP_CPSF5.2.2 m.66646 sp CPSF5_DANRE 88.601 193 22 0 137 329 36 228 5.04E-125 360 CPSF5_DANRE reviewed Cleavage and polyadenylation specificity factor subunit 5 cpsf5 Danio rerio (Zebrafish) (Brachydanio rerio) 228 mRNA polyadenylation [GO:0006378]; mRNA processing [GO:0006397] GO:0003729; GO:0005849; GO:0006378; GO:0006397; GO:0016787; GO:0017091; GO:0042382 0 0 0 PF13869; Q7ZV80 CHOYP_TEC.1.1 m.54461 sp SPF30_DANRE 52.838 229 98 4 2 228 9 229 5.04E-76 232 SPF30_DANRE reviewed Survival of motor neuron-related-splicing factor 30 (Survival motor neuron domain-containing protein 1) smndc1 spf30 Danio rerio (Zebrafish) (Brachydanio rerio) 237 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0003723; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0015030; GO:0016607 0 0 0 PF06003; Q8CGF7 CHOYP_LOC659146.1.1 m.6067 sp TCRG1_MOUSE 49.412 85 43 0 1 85 713 797 5.04E-22 93.2 TCRG1_MOUSE reviewed Transcription elongation regulator 1 (Formin-binding protein 28) (FBP 28) (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) (p144) Tcerg1 Taf2s Mus musculus (Mouse) 1100 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001103; GO:0001106; GO:0003700; GO:0005634; GO:0005730; GO:0006351; GO:0015629; GO:0044822; GO:0070064 0 0 0 PF01846;PF00397; Q8K3A2 CHOYP_LOC100712543.1.1 m.9077 sp TRPT1_MOUSE 42.623 183 96 5 16 190 34 215 5.04E-41 142 TRPT1_MOUSE reviewed tRNA 2'-phosphotransferase 1 (mTPT1) (EC 2.7.1.160) Trpt1 Tpt1h Mus musculus (Mouse) 249 "regulation of protein kinase activity [GO:0045859]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388; GO:0008665; GO:0045859 0 0 0 PF01885; Q8SX83 CHOYP_SAFB2.1.3 m.11136 sp SPEN_DROME 33.654 104 64 3 216 318 1998 2097 5.04E-07 56.2 SPEN_DROME reviewed Protein split ends spen CG18497 Drosophila melanogaster (Fruit fly) 5560 "axon guidance [GO:0007411]; compound eye development [GO:0048749]; defense response to fungus [GO:0050832]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of thoracic bristle planar orientation [GO:0048106]; glial cell fate determination [GO:0007403]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; maintenance of imaginal disc-derived wing hair orientation [GO:0035321]; mRNA splicing, via spliceosome [GO:0000398]; neuroblast fate determination [GO:0007400]; peripheral nervous system development [GO:0007422]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of transcription, DNA-templated [GO:0006355]; segment specification [GO:0007379]; sleep [GO:0030431]; transcription, DNA-templated [GO:0006351]; wing disc pattern formation [GO:0035222]; Wnt signaling pathway [GO:0016055]" GO:0000166; GO:0000398; GO:0003676; GO:0003723; GO:0005634; GO:0006351; GO:0006355; GO:0007173; GO:0007379; GO:0007400; GO:0007403; GO:0007411; GO:0007422; GO:0008586; GO:0016055; GO:0030177; GO:0030431; GO:0035222; GO:0035321; GO:0048106; GO:0048749; GO:0050832 0 0 0 PF00076;PF07744; Q8VI63 CHOYP_ISCW_ISCW022842.1.1 m.5648 sp MOB2_MOUSE 50.952 210 100 2 50 259 1 207 5.04E-72 224 MOB2_MOUSE reviewed MOB kinase activator 2 (Mob2 homolog) (Mps one binder kinase activator-like 2) (Ovary-specific MOB-like protein) Mob2 Mmh Mus musculus (Mouse) 235 actin cytoskeleton organization [GO:0030036]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein phosphorylation [GO:0001934] GO:0001934; GO:0005634; GO:0005730; GO:0005737; GO:0010976; GO:0030036; GO:0044306; GO:0046872; GO:0048471 0 0 0 PF03637; Q96FN5 CHOYP_LOC100902075.1.1 m.10103 sp KIF12_HUMAN 42.604 507 247 9 85 589 26 490 5.04E-115 365 KIF12_HUMAN reviewed Kinesin-like protein KIF12 KIF12 Homo sapiens (Human) 646 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007018; GO:0016887; GO:0070062 0 0 0 PF00225; Q96RW7 CHOYP_NEMVEDRAFT_V1G207416.1.1 m.55693 sp HMCN1_HUMAN 38.298 141 68 6 59 195 4572 4697 5.04E-18 85.9 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9UKN7 CHOYP_LOC100901924.1.3 m.44085 sp MYO15_HUMAN 31.381 905 547 20 139 999 2645 3519 5.04E-141 471 MYO15_HUMAN reviewed Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) 3530 inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0007626; GO:0016459; GO:0032420; GO:0042472; GO:0070062 0 0 0 PF00373;PF00612;PF00063;PF00784;PF07653; D3YXG0 CHOYP_DANA_GF12383.1.1 m.47591 sp HMCN1_MOUSE 24.342 608 384 25 122 680 2557 3137 5.05E-23 110 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O70244 CHOYP_MASP2.1.1 m.3029 sp CUBN_RAT 31.333 150 92 5 108 250 1035 1180 5.05E-11 67.8 CUBN_RAT reviewed Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) 3623 cholesterol metabolic process [GO:0008203]; cobalamin transport [GO:0015889]; hemoglobin import [GO:0020028]; in utero embryonic development [GO:0001701]; protein homotrimerization [GO:0070207]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to nutrient [GO:0007584]; vitamin metabolic process [GO:0006766] GO:0001701; GO:0004872; GO:0005509; GO:0005765; GO:0005905; GO:0006766; GO:0006898; GO:0007584; GO:0008203; GO:0010008; GO:0015031; GO:0015235; GO:0015889; GO:0016020; GO:0020028; GO:0030135; GO:0030492; GO:0030666; GO:0031419; GO:0031526; GO:0042802; GO:0043202; GO:0043234; GO:0070207 0 0 0 PF00431;PF00008;PF12947;PF07645; O70497 CHOYP_BRAFLDRAFT_86061.6.13 m.48809 sp FCN2_MOUSE 53.302 212 96 3 114 324 103 312 5.05E-76 238 FCN2_MOUSE reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Mus musculus (Mouse) 314 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of interleukin-8 secretion [GO:2000484]; protein localization to cell surface [GO:0034394]; recognition of apoptotic cell [GO:0043654]" GO:0001664; GO:0001867; GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0033691; GO:0034394; GO:0043654; GO:0046597; GO:0046872; GO:0097367; GO:2000484 0 0 0 PF01391;PF00147; O75382 CHOYP_BRAFLDRAFT_255130.1.3 m.20552 sp TRIM3_HUMAN 29.6 125 83 3 155 277 622 743 5.05E-09 62 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P05450 CHOYP_BRAFLDRAFT_68342.2.2 m.65978 sp YAT7_RHOBL 43.478 69 39 0 88 156 36 104 5.05E-13 64.7 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P06797 CHOYP_NEMVEDRAFT_V1G180651.1.2 m.2808 sp CATL1_MOUSE 56.522 322 130 6 67 381 15 333 5.05E-124 363 CATL1_MOUSE reviewed Cathepsin L1 (EC 3.4.22.15) (Cathepsin L) (Major excreted protein) (MEP) (p39 cysteine proteinase) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain] Ctsl Ctsl1 Mus musculus (Mouse) 334 autophagic cell death [GO:0048102]; cell communication [GO:0007154]; cellular response to starvation [GO:0009267]; decidualization [GO:0046697]; hair follicle morphogenesis [GO:0031069]; male gonad development [GO:0008584]; multicellular organism aging [GO:0010259]; negative regulation of keratinocyte proliferation [GO:0010839]; nerve development [GO:0021675]; protein autoprocessing [GO:0016540]; protein processing [GO:0016485]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of actin cytoskeleton reorganization [GO:2000249]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to gonadotropin [GO:0034698]; response to organic cyclic compound [GO:0014070]; Sertoli cell differentiation [GO:0060008]; spermatogenesis [GO:0007283] GO:0004177; GO:0004197; GO:0005615; GO:0005634; GO:0005730; GO:0005737; GO:0005764; GO:0005773; GO:0005902; GO:0006508; GO:0007154; GO:0007283; GO:0008584; GO:0009267; GO:0009749; GO:0009897; GO:0010259; GO:0010839; GO:0014070; GO:0016485; GO:0016540; GO:0016807; GO:0021675; GO:0030141; GO:0031069; GO:0031410; GO:0034698; GO:0042277; GO:0042393; GO:0043005; GO:0043204; GO:0045177; GO:0046697; GO:0048102; GO:0051384; GO:0051603; GO:0060008; GO:0070062; GO:2000249 0 0 0 PF08246;PF00112; P19493 CHOYP_GRIK3.1.2 m.1113 sp GRIA4_RAT 30.867 473 285 14 19 471 413 863 5.05E-57 207 GRIA4_RAT reviewed "Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4)" Gria4 Glur4 Rattus norvegicus (Rat) 902 "chemical synaptic transmission [GO:0007268]; modulation of synaptic transmission [GO:0050804]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of synapse structure or activity [GO:0050803]; response to fungicide [GO:0060992]" GO:0004970; GO:0004971; GO:0005234; GO:0007268; GO:0008328; GO:0014069; GO:0030054; GO:0030425; GO:0032281; GO:0032983; GO:0043025; GO:0043195; GO:0045202; GO:0045211; GO:0050803; GO:0050804; GO:0051968; GO:0060992 0 0 0 PF01094;PF00060;PF10613; P29314 CHOYP_RS9.2.13 m.29265 sp RS9_RAT 73.184 179 37 3 5 174 1 177 5.05E-84 250 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; Q07837 CHOYP_BRAFLDRAFT_265208.5.7 m.49177 sp SLC31_HUMAN 33.333 213 124 10 17 216 443 650 5.05E-19 88.2 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q0P6H9 CHOYP_TMM62.1.1 m.55752 sp TMM62_HUMAN 40.159 503 275 7 1 491 63 551 5.05E-118 363 TMM62_HUMAN reviewed Transmembrane protein 62 TMEM62 Homo sapiens (Human) 643 0 GO:0016021; GO:0016787 0 0 0 PF00149; Q32PJ7 CHOYP_DVIR_GJ12450.1.1 m.8873 sp TENS4_BOVIN 36.8 125 64 3 104 213 449 573 5.05E-16 80.1 TENS4_BOVIN reviewed Tensin-4 TNS4 Bos taurus (Bovine) 716 apoptotic process [GO:0006915] GO:0005737; GO:0005856; GO:0005925; GO:0006915 0 0 0 PF08416;PF00017; Q6ZRF8 CHOYP_TIF1B.4.10 m.13551 sp RN207_HUMAN 31.868 91 56 4 16 104 103 189 5.05E-08 53.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q74GW7 CHOYP_LOC100377968.1.1 m.10750 sp TTCA_GEOSL 36.323 223 138 2 812 1033 18 237 5.05E-39 149 TTCA_GEOSL reviewed tRNA 2-thiocytidine biosynthesis protein TtcA ttcA GSU0127 Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) 257 tRNA processing [GO:0008033] GO:0005524; GO:0005737; GO:0008033 0 0 0 PF01171; Q90YS3 CHOYP_RS2.3.10 m.19694 sp RS2_ICTPU 86.893 206 27 0 1 206 69 274 5.05E-132 376 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q9BX66 CHOYP_LOC100867381.4.8 m.28245 sp SRBS1_HUMAN 33.034 669 315 27 305 865 286 929 5.05E-64 241 SRBS1_HUMAN reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) 1292 cell-matrix adhesion [GO:0007160]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; muscle contraction [GO:0006936]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0003779; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005913; GO:0005915; GO:0005924; GO:0005925; GO:0006936; GO:0007160; GO:0008092; GO:0008286; GO:0015758; GO:0016363; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q9I931 CHOYP_FUCL1.1.1 m.28893 sp FUCL1_ANGJA 33.333 177 106 8 3 174 2 171 5.05E-15 72.4 FUCL1_ANGJA reviewed Fucolectin-1 0 Anguilla japonica (Japanese eel) 178 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9JI85 CHOYP_NUCB2.2.2 m.55289 sp NUCB2_RAT 49.014 355 161 4 6 352 12 354 5.05E-98 308 NUCB2_RAT reviewed Nucleobindin-2 (DNA-binding protein NEFA) (Prepronesfatin) [Cleaved into: Nesfatin-1] Nucb2 Nefa Rattus norvegicus (Rat) 420 insulin metabolic process [GO:1901142]; negative regulation of appetite [GO:0032099]; negative regulation of cAMP biosynthetic process [GO:0030818]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of insulin receptor signaling pathway [GO:0046627]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of testosterone secretion [GO:2000845]; response to glucose [GO:0009749]; response to human chorionic gonadotropin [GO:0044752]; response to melanocyte-stimulating hormone [GO:1990680]; response to starvation [GO:0042594] GO:0003677; GO:0005164; GO:0005509; GO:0005615; GO:0005635; GO:0005737; GO:0005783; GO:0005797; GO:0009749; GO:0016020; GO:0030818; GO:0032099; GO:0042594; GO:0044752; GO:0045599; GO:0046321; GO:0046627; GO:0070093; GO:1901142; GO:1990680; GO:2000845 0 0 0 PF13499; A0PK84 CHOYP_ZDH14.2.2 m.37108 sp ZDH22_MOUSE 27.273 253 159 6 31 275 14 249 5.06E-28 112 ZDH22_MOUSE reviewed Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) Zdhhc22 Gm262 Mus musculus (Mouse) 263 protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345] GO:0005783; GO:0005794; GO:0008270; GO:0016021; GO:0018345; GO:0019706; GO:0072659 0 0 0 PF01529; A2AWH2 CHOYP_LOC100486518.1.1 m.1595 sp F155A_DANRE 28.571 175 104 5 85 242 143 313 5.06E-11 66.6 F155A_DANRE reviewed Transmembrane protein FAM155A fam155a si:dkey-48f17.1 zgc:158322 Danio rerio (Zebrafish) (Brachydanio rerio) 401 0 GO:0016021 0 0 0 0 D2GXS7 CHOYP_BRAFLDRAFT_88219.5.5 m.61451 sp TRIM2_AILME 24.091 220 146 7 240 449 534 742 5.06E-09 62 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14490 CHOYP_DLGP1.3.3 m.44296 sp DLGP1_HUMAN 45.614 114 61 1 687 800 790 902 5.06E-26 119 DLGP1_HUMAN reviewed Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) DLGAP1 DAP1 GKAP Homo sapiens (Human) 977 chemical synaptic transmission [GO:0007268] GO:0007268; GO:0014069; GO:0030054; GO:0045211 0 0 0 PF03359; O16025 CHOYP_LOC584481.4.10 m.29669 sp AOSL_PLEHO 33.761 702 412 18 4 663 376 1066 5.06E-115 372 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O60494 CHOYP_CUBN.4.7 m.51181 sp CUBN_HUMAN 25.714 245 153 9 37 275 1750 1971 5.06E-14 78.2 CUBN_HUMAN reviewed Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) 3623 cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; tissue homeostasis [GO:0001894]; vitamin D metabolic process [GO:0042359] GO:0001894; GO:0004872; GO:0005215; GO:0005509; GO:0005765; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0005905; GO:0006898; GO:0008203; GO:0009235; GO:0010008; GO:0015031; GO:0015889; GO:0016020; GO:0016324; GO:0030139; GO:0031232; GO:0031419; GO:0031526; GO:0042157; GO:0042359; GO:0042803; GO:0042953; GO:0043202; GO:0070062 0 0 0 PF00431;PF00008;PF12947;PF07645; O95149 CHOYP_LOC101077787.2.3 m.65668 sp SPN1_HUMAN 45.013 371 189 7 14 381 1 359 5.06E-108 325 SPN1_HUMAN reviewed Snurportin-1 (RNA U transporter 1) SNUPN RNUT1 SPN1 Homo sapiens (Human) 360 nuclear import [GO:0051170]; protein import into nucleus [GO:0006606]; snRNA import into nucleus [GO:0061015]; spliceosomal snRNP assembly [GO:0000387] GO:0000339; GO:0000387; GO:0005643; GO:0005829; GO:0006606; GO:0008565; GO:0051170; GO:0061015; GO:0070062 0 0 0 PF11538; P17671 CHOYP_E75BB.1.1 m.43378 sp E75BC_DROME 31.778 343 211 6 173 493 243 584 5.06E-51 190 E75BC_DROME reviewed "Ecdysone-induced protein 75B, isoforms C/D (E75-A) (Nuclear receptor subfamily 1 group D member 3, isoforms C/D)" Eip75B NR1D3 CG8127 Drosophila melanogaster (Fruit fly) 1199 "antimicrobial humoral response [GO:0019730]; ecdysis, chitin-based cuticle [GO:0018990]; molting cycle, chitin-based cuticle [GO:0007591]; multicellular organism development [GO:0007275]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; oogenesis [GO:0048477]; regulation of ecdysteroid metabolic process [GO:0007553]; regulation of gene expression [GO:0010468]; regulation of glucose metabolic process [GO:0010906]; response to ecdysone [GO:0035075]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003707; GO:0004879; GO:0004887; GO:0005634; GO:0006351; GO:0007275; GO:0007553; GO:0007591; GO:0008270; GO:0010468; GO:0010906; GO:0018990; GO:0019730; GO:0020037; GO:0035075; GO:0043565; GO:0048477 0 0 0 PF00104;PF00105; P56404 CHOYP_BRAFLDRAFT_64447.1.1 m.40135 sp AQP8_MOUSE 34.934 229 135 6 2 225 32 251 5.06E-37 133 AQP8_MOUSE reviewed Aquaporin-8 (AQP-8) Aqp8 Mus musculus (Mouse) 261 cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; water transport [GO:0006833] GO:0005887; GO:0006833; GO:0009992; GO:0015250; GO:0015254; GO:0034220; GO:0045177 0 0 0 PF00230; P81139 CHOYP_LOC100177659.1.1 m.36271 sp LIPR2_CAVPO 37.037 297 170 8 438 722 26 317 5.06E-49 181 LIPR2_CAVPO reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (GPL) (Galactolipase) PNLIPRP2 Cavia porcellus (Guinea pig) 434 galactolipid catabolic process [GO:0019376]; lipid metabolic process [GO:0006629]; phospholipid catabolic process [GO:0009395] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0006629; GO:0009395; GO:0019376; GO:0047372; GO:0047714 0 0 0 PF00151;PF01477; P86948 CHOYP_MP.1.4 m.5729 sp MP_PINMA 41.841 239 132 1 1 232 1 239 5.06E-42 146 MP_PINMA reviewed Mantle protein (MP) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 260 0 GO:0005576 0 0 0 0 Q09654 CHOYP_NEMVEDRAFT_V1G126319.1.1 m.60331 sp TRI23_CAEEL 31.034 116 73 4 11 119 106 221 5.06E-06 47.8 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q11118 CHOYP_LOC100554313.1.1 m.20950 sp WOS2_SCHPO 33.333 141 83 4 7 136 8 148 5.06E-16 74.7 WOS2_SCHPO reviewed Protein wos2 (p21) wos2 SPAC9E9.13 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 186 cell cycle [GO:0007049] GO:0005634; GO:0005829; GO:0007049 0 0 0 PF04969; Q4R7I8 CHOYP_LOC100864501.1.1 m.7850 sp HAKAI_MACFA 42.18 211 103 7 9 212 2 200 5.06E-38 148 HAKAI_MACFA reviewed E3 ubiquitin-protein ligase Hakai (EC 6.3.2.-) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) CBLL1 HAKAI QtsA-15158 QtsA-17111 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 490 negative regulation of cell adhesion [GO:0007162]; positive regulation of cell migration [GO:0030335]; positive regulation of endocytosis [GO:0045807] GO:0004842; GO:0007162; GO:0008270; GO:0016607; GO:0016874; GO:0030335; GO:0045807 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q4V838 CHOYP_LTV1.1.1 m.19482 sp LTV1_XENLA 50.524 477 194 10 1 443 1 469 5.06E-130 386 LTV1_XENLA reviewed Protein LTV1 homolog ltv1 Xenopus laevis (African clawed frog) 469 0 0 0 0 0 PF04180; Q4V8C9 CHOYP_LOC100378322.1.1 m.16268 sp LRC56_RAT 37.867 375 189 10 55 422 50 387 5.06E-60 214 LRC56_RAT reviewed Leucine-rich repeat-containing protein 56 Lrrc56 Rattus norvegicus (Rat) 548 0 0 0 0 0 PF12799; Q5R930 CHOYP_MSRB3.1.4 m.4844 sp MSRB3_PONAB 54.676 139 61 2 58 194 32 170 5.06E-52 168 MSRB3_PONAB reviewed Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.-) MSRB3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 190 protein repair [GO:0030091]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005783; GO:0006979; GO:0008270; GO:0030091; GO:0033743 0 0 0 PF01641; Q6R7I1 CHOYP_IAP1.2.4 m.30874 sp Y043_OSHVF 100 203 0 0 1 203 1 203 5.06E-150 417 Y043_OSHVF reviewed Uncharacterized protein ORF43 ORF43 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 203 0 0 0 0 0 0 Q8BIY1 CHOYP_LOC100375338.1.1 m.16993 sp GPTC3_MOUSE 43.993 541 232 11 13 523 14 513 5.06E-136 407 GPTC3_MOUSE reviewed G patch domain-containing protein 3 Gpatch3 Gpatc3 Mus musculus (Mouse) 525 0 GO:0003676 0 0 0 PF01585; Q8BYF6 CHOYP_BRAFLDRAFT_268046.1.3 m.30265 sp SC5A8_MOUSE 44.485 544 290 6 5 539 9 549 5.06E-150 450 SC5A8_MOUSE reviewed Sodium-coupled monocarboxylate transporter 1 (Electrogenic sodium monocarboxylate cotransporter) (Solute carrier family 5 member 8) Slc5a8 Smct Smct1 Mus musculus (Mouse) 611 apoptotic process [GO:0006915]; sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0006915; GO:0015293; GO:0016324; GO:0070062 0 0 0 PF00474; Q8CDF7 CHOYP_UNC89.16.19 m.57422 sp EXD1_MOUSE 33.974 156 89 6 972 1121 97 244 5.06E-09 64.3 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q90932 CHOYP_BRAFLDRAFT_117858.3.3 m.61649 sp NFIX_CHICK 63.498 263 86 3 1 263 7 259 5.06E-110 340 NFIX_CHICK reviewed Nuclear factor 1 X-type (NF1-X) (Nuclear factor 1/X) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/X) (NF-I/X) (NFI-X) (TGGCA-binding protein) NFIX NFI-X Gallus gallus (Chicken) 431 "DNA replication [GO:0006260]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000981; GO:0003677; GO:0005634; GO:0006260; GO:0006351; GO:0045944 0 0 0 PF00859;PF03165;PF10524; D2GXS7 CHOYP_LOC100634336.1.4 m.3230 sp TRIM2_AILME 35.443 79 49 2 33 110 631 708 5.07E-06 47 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5E8K5 CHOYP_TVAG_168010.26.45 m.54134 sp ANK3_MOUSE 33.121 314 209 1 16 328 390 703 5.07E-52 190 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P0C6B8 CHOYP_LOC100879487.3.3 m.33048 sp SVEP1_RAT 28.777 417 267 13 1088 1496 1213 1607 5.07E-40 167 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P16157 CHOYP_LOC100635111.11.13 m.61147 sp ANK1_HUMAN 33.996 553 337 4 282 812 240 786 5.07E-76 273 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22856 CHOYP_LOC101267440.1.1 m.59348 sp VL96_IRV1 26.582 158 98 4 264 411 595 744 5.07E-11 68.6 VL96_IRV1 reviewed Putative ubiquitin thioesterase L96 (EC 3.4.19.12) L96 Tipula iridescent virus (TIV) (Insect iridescent virus type 1) 867 "DNA-templated transcription, termination [GO:0006353]; viral release from host cell [GO:0019076]" GO:0003677; GO:0006353; GO:0019076; GO:0036459 0 0 0 PF02338; P25931 CHOYP_NPBW2.1.1 m.51442 sp NPYR_DROME 27.6 250 167 8 20 262 87 329 5.07E-10 63.9 NPYR_DROME reviewed Neuropeptide Y receptor (NPY-R) (PR4 receptor) (RYamide receptor) RYa-R NepYr CG5811 Drosophila melanogaster (Fruit fly) 464 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0001653; GO:0004983; GO:0005886; GO:0007166; GO:0007186; GO:0008188; GO:0016021 0 0 0 PF00001; P48725 CHOYP_contig_002880 m.3202 sp PCNT_MOUSE 37.391 115 66 3 1 113 2721 2831 5.07E-14 71.2 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; P53816 CHOYP_BRAFLDRAFT_119296.1.16 m.4209 sp HRSL3_HUMAN 34.177 158 92 4 21 171 2 154 5.07E-17 77.8 HRSL3_HUMAN reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (HRAS-like suppressor 1) (HREV107-1) (HREV107-3) (Renal carcinoma antigen NY-REN-65) PLA2G16 HRASLS3 HREV107 Homo sapiens (Human) 162 lipid catabolic process [GO:0016042]; negative regulation of cell cycle [GO:0045786]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid biosynthetic process [GO:0008654]; phospholipid metabolic process [GO:0006644] GO:0004623; GO:0005783; GO:0005829; GO:0006644; GO:0008654; GO:0008970; GO:0016021; GO:0016042; GO:0036149; GO:0036150; GO:0036151; GO:0036152; GO:0045786; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; P86856 CHOYP_MANL.4.9 m.27748 sp MANL_MYTCA 35.106 376 134 10 123 457 2 308 5.07E-54 187 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q01240 CHOYP_NF70.1.4 m.31159 sp NF60_DORPE 56.568 472 193 5 7 477 2 462 5.07E-172 513 NF60_DORPE reviewed 60 kDa neurofilament protein (NF60) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 511 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q14146 CHOYP_URB2.1.2 m.8118 sp URB2_HUMAN 30.723 166 109 4 147 308 359 522 5.07E-17 85.1 URB2_HUMAN reviewed Unhealthy ribosome biogenesis protein 2 homolog URB2 KIAA0133 Homo sapiens (Human) 1524 0 GO:0005730; GO:0016235 0 0 0 PF10441; Q3V1V3 CHOYP_ESF1.1.1 m.15088 sp ESF1_MOUSE 42.333 600 282 17 272 856 293 843 5.07E-124 397 ESF1_MOUSE reviewed ESF1 homolog (ABT1-associated protein) Esf1 Abtap Mus musculus (Mouse) 845 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005615; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0044822 0 0 0 PF08159; Q5TZ51 CHOYP_LOC100899945.3.3 m.66490 sp MPV17_DANRE 37.234 94 56 2 1 91 1 94 5.07E-13 65.1 MPV17_DANRE reviewed Protein Mpv17 mpv17 zgc:63573 Danio rerio (Zebrafish) (Brachydanio rerio) 177 0 GO:0005743; GO:0016021 0 0 0 PF04117; Q8CDF7 CHOYP_UNC89.19.19 m.59123 sp EXD1_MOUSE 33.974 156 89 6 903 1052 97 244 5.07E-09 64.3 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q8WP23 CHOYP_LOC100892519.2.4 m.5554 sp BOLL_MACFA 34.839 155 58 8 3 155 89 202 5.07E-09 58.9 BOLL_MACFA reviewed Protein boule-like BOLL QtsA-21032 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 283 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283] GO:0000166; GO:0003723; GO:0005737; GO:0006417; GO:0007275; GO:0007283; GO:0030154 0 0 0 PF00076; Q96MM6 CHOYP_BRAFLDRAFT_208436.23.32 m.59515 sp HS12B_HUMAN 30.599 634 373 11 36 610 58 683 5.07E-100 322 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9JJ80 CHOYP_RPF2.2.2 m.27891 sp RPF2_MOUSE 63.907 302 109 0 2 303 3 304 5.07E-142 405 RPF2_MOUSE reviewed Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog) Rpf2 Bxdc1 MNCb-4285 Mus musculus (Mouse) 306 "maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; ribosomal large subunit assembly [GO:0000027]" GO:0000027; GO:0000463; GO:0005634; GO:0005730; GO:0019843; GO:0044822 0 0 0 PF04427; Q9N294 CHOYP_LOC100934353.1.1 m.11771 sp B3GT5_PANPA 34.553 246 158 2 83 328 48 290 5.07E-47 164 B3GT5_PANPA reviewed "Beta-1,3-galactosyltransferase 5 (Beta-1,3-GalTase 5) (Beta3Gal-T5) (Beta3GalT5) (b3Gal-T5) (EC 2.4.1.-) (Beta-3-Gx-T5) (UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5) (Fragment)" B3GALT5 Pan paniscus (Pygmy chimpanzee) (Bonobo) 301 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9PRL8 CHOYP_ACBP.1.4 m.15501 sp ACBP_CHICK 70.588 85 25 0 28 112 2 86 5.07E-39 128 ACBP_CHICK reviewed Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) DBI Gallus gallus (Chicken) 86 transport [GO:0006810] GO:0000062; GO:0005783; GO:0005794; GO:0006810; GO:0008289 0 0 0 PF00887; Q9WVH6 CHOYP_BRAFLDRAFT_108085.1.3 m.32898 sp ANGP4_MOUSE 49.02 51 25 1 173 223 293 342 5.07E-11 65.1 ANGP4_MOUSE reviewed Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) Angpt4 Agpt4 Ang3 Mus musculus (Mouse) 509 angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; endoderm development [GO:0007492]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; Tie signaling pathway [GO:0048014] GO:0001525; GO:0005172; GO:0005615; GO:0007219; GO:0007492; GO:0010595; GO:0016525; GO:0030297; GO:0030971; GO:0043066; GO:0043536; GO:0043537; GO:0045766; GO:0048014; GO:0050731; GO:0071456 0 0 0 PF00147; Q9WWW2 CHOYP_LOC100118063.3.4 m.39704 sp ALKJ_PSEPU 40.271 591 287 17 38 606 2 548 5.07E-119 367 ALKJ_PSEPU reviewed Alcohol dehydrogenase [acceptor] (EC 1.1.99.-) alkJ Pseudomonas putida (Arthrobacter siderocapsulatus) 552 0 GO:0005886; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; A1L2F3 CHOYP_NSAPB.1.2 m.11765 sp NUSAP_DANRE 28.953 487 264 14 75 525 3 443 5.08E-27 117 NUSAP_DANRE reviewed Nucleolar and spindle-associated protein 1 (NuSAP) nusap1 Danio rerio (Zebrafish) (Brachydanio rerio) 446 establishment of mitotic spindle localization [GO:0040001]; mitotic cytokinesis [GO:0000281]; mitotic nuclear division [GO:0007067]; neural crest cell migration [GO:0001755] GO:0000281; GO:0001755; GO:0003677; GO:0005634; GO:0005737; GO:0005819; GO:0005874; GO:0007067; GO:0040001 0 0 0 PF16006; A4IF63 CHOYP_BRAFLDRAFT_69798.22.22 m.65643 sp TRIM2_BOVIN 22.642 212 132 7 152 347 492 687 5.08E-07 55.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IFD0 CHOYP_AK5.2.2 m.42812 sp KAD5_BOVIN 45.455 66 35 1 9 73 5 70 5.08E-12 63.9 KAD5_BOVIN reviewed Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) Ak5 Bos taurus (Bovine) 562 ATP metabolic process [GO:0046034]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142] GO:0004017; GO:0004550; GO:0005524; GO:0005737; GO:0005815; GO:0006165; GO:0009142; GO:0046034 0 0 cd01428; 0 A7SJ66 CHOYP_BRAFLDRAFT_120923.2.3 m.49934 sp U587_NEMVE 62.205 127 48 0 1 127 1 127 5.08E-56 175 U587_NEMVE reviewed UPF0587 protein v1g245604 v1g245604 Nematostella vectensis (Starlet sea anemone) 159 0 0 0 0 0 PF05907; B5X7X4 CHOYP_LTOR2.2.2 m.61709 sp LTOR2_SALSA 77.6 125 28 0 178 302 1 125 5.08E-65 203 LTOR2_SALSA reviewed Ragulator complex protein LAMTOR2 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) lamtor2 Salmo salar (Atlantic salmon) 125 cell growth [GO:0016049]; cellular protein localization [GO:0034613]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008] GO:0005765; GO:0005770; GO:0016049; GO:0032008; GO:0034613; GO:0043547; GO:0071230; GO:0071986 0 0 0 PF03259; D2GXS7 CHOYP_LOC100369333.8.32 m.28515 sp TRIM2_AILME 25.194 258 176 7 157 402 492 744 5.08E-14 77.4 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P26652 CHOYP_LOC100142611.2.2 m.66701 sp TIMP3_CHICK 35.461 141 83 4 16 152 20 156 5.08E-18 81.3 TIMP3_CHICK reviewed Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) 212 negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] GO:0002020; GO:0005578; GO:0005615; GO:0008191; GO:0010033; GO:0043086; GO:0046872; GO:0051045 0 0 0 PF00965; P48430 CHOYP_SOX2.1.2 m.31411 sp SOX2_CHICK 52.443 307 113 10 51 327 12 315 5.08E-79 246 SOX2_CHICK reviewed Transcription factor SOX-2 (cSox2) (delta EF2a) SOX2 Gallus gallus (Chicken) 315 "cell cycle arrest [GO:0007050]; endodermal cell fate specification [GO:0001714]; eye development [GO:0001654]; inner ear development [GO:0048839]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuron differentiation [GO:0045665]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; response to growth factor [GO:0070848]; response to wounding [GO:0009611]; sensory organ precursor cell fate determination [GO:0016360]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]" GO:0001649; GO:0001654; GO:0001714; GO:0003700; GO:0005623; GO:0005634; GO:0005654; GO:0005829; GO:0006351; GO:0007050; GO:0009611; GO:0016360; GO:0021983; GO:0035019; GO:0035198; GO:0043281; GO:0043410; GO:0043565; GO:0044212; GO:0045665; GO:0045893; GO:0045944; GO:0048839; GO:0050680; GO:0070848; GO:0090090 0 0 0 PF00505;PF12336; P48430 CHOYP_SOX2.2.2 m.61089 sp SOX2_CHICK 52.443 307 113 10 51 327 12 315 5.08E-79 246 SOX2_CHICK reviewed Transcription factor SOX-2 (cSox2) (delta EF2a) SOX2 Gallus gallus (Chicken) 315 "cell cycle arrest [GO:0007050]; endodermal cell fate specification [GO:0001714]; eye development [GO:0001654]; inner ear development [GO:0048839]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of neuron differentiation [GO:0045665]; osteoblast differentiation [GO:0001649]; pituitary gland development [GO:0021983]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; response to growth factor [GO:0070848]; response to wounding [GO:0009611]; sensory organ precursor cell fate determination [GO:0016360]; somatic stem cell population maintenance [GO:0035019]; transcription, DNA-templated [GO:0006351]" GO:0001649; GO:0001654; GO:0001714; GO:0003700; GO:0005623; GO:0005634; GO:0005654; GO:0005829; GO:0006351; GO:0007050; GO:0009611; GO:0016360; GO:0021983; GO:0035019; GO:0035198; GO:0043281; GO:0043410; GO:0043565; GO:0044212; GO:0045665; GO:0045893; GO:0045944; GO:0048839; GO:0050680; GO:0070848; GO:0090090 0 0 0 PF00505;PF12336; P55266 CHOYP_ADAR.2.3 m.45677 sp DSRAD_RAT 26.257 179 108 2 9 166 563 738 5.08E-10 60.8 DSRAD_RAT reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) Adar Dsrad Rattus norvegicus (Rat) 1175 "adenosine to inosine editing [GO:0006382]; defense response to virus [GO:0051607]; gene silencing by RNA [GO:0031047]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; positive regulation of viral genome replication [GO:0045070]; regulation of transcription, DNA-templated [GO:0006355]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0003726; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0006382; GO:0006397; GO:0009615; GO:0016607; GO:0031047; GO:0035455; GO:0044387; GO:0044530; GO:0045070; GO:0045087; GO:0046872; GO:0051607 0 0 0 PF02137;PF00035;PF02295; P62155 CHOYP_LOC100372664.2.2 m.59091 sp CALM_XENLA 98.947 95 1 0 1 95 1 95 5.08E-63 191 CALM_XENLA reviewed Calmodulin (CaM) calm1; calm2 Xenopus laevis (African clawed frog) 149 0 GO:0005102; GO:0005509 0 0 0 PF13499; Q04735 CHOYP_LOC100376832.1.1 m.41142 sp CDK16_MOUSE 30 150 59 3 2 127 4 131 5.08E-09 56.2 CDK16_MOUSE reviewed Cyclin-dependent kinase 16 (EC 2.7.11.22) (CRK5) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) Cdk16 Crk5 Pctaire1 Pctk1 Mus musculus (Mouse) 496 exocytosis [GO:0006887]; growth hormone secretion [GO:0030252]; neuron projection development [GO:0031175]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; spermatogenesis [GO:0007283] GO:0004674; GO:0004693; GO:0005524; GO:0005737; GO:0005886; GO:0006887; GO:0007283; GO:0015630; GO:0030054; GO:0030133; GO:0030252; GO:0031175; GO:0031234; GO:0043005; GO:0045202; GO:0061178 0 0 0 PF00069; Q2TBT5 CHOYP_BRAFLDRAFT_285333.1.1 m.12846 sp RNH2A_BOVIN 51.864 295 142 0 1 295 1 295 5.08E-107 316 RNH2A_BOVIN reviewed Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) RNASEH2A Bos taurus (Bovine) 299 "DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]" GO:0003723; GO:0004523; GO:0005654; GO:0005737; GO:0006298; GO:0006401; GO:0032299; GO:0043137; GO:0046872 0 0 0 PF01351; Q3TLH4 CHOYP_LOC100559941.1.2 m.12240 sp PRC2C_MOUSE 37.075 588 255 22 1 569 1 492 5.08E-62 241 PRC2C_MOUSE reviewed Protein PRRC2C (BAT2 domain-containing protein 1) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C) Prrc2c Bat2d Bat2d1 Bat2l2 Kiaa1096 Mus musculus (Mouse) 2846 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244; GO:0008022; GO:0016020; GO:0044822 0 0 0 PF07001; Q3ZBG9 CHOYP_LOC585374.1.1 m.12728 sp PLS2_BOVIN 58.955 268 97 5 1 258 24 288 5.08E-106 312 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q5BKW7 CHOYP_ENPP6.1.5 m.4896 sp ENPP6_DANRE 39.43 421 242 5 2 415 8 422 5.08E-115 347 ENPP6_DANRE reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine cholinephosphodiesterase) (GPC-Cpde) enpp6 zgc:103605 Danio rerio (Zebrafish) (Brachydanio rerio) 438 choline metabolic process [GO:0019695]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629] GO:0005886; GO:0006629; GO:0008081; GO:0016042; GO:0019695; GO:0031225; GO:0047390 0 0 0 PF01663; Q5RC53 CHOYP_GLRX2.1.1 m.19246 sp GLRX2_PONAB 48.421 95 49 0 50 144 57 151 5.08E-30 109 GLRX2_PONAB reviewed "Glutaredoxin-2, mitochondrial" GLRX2 GRX2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 161 cell redox homeostasis [GO:0045454] GO:0005739; GO:0009055; GO:0015035; GO:0045454; GO:0046872; GO:0051537 0 0 0 PF00462; Q5SRD1 CHOYP_ISCW_ISCW004474.1.1 m.64180 sp TI23B_HUMAN 31.325 166 94 4 16 180 26 172 5.08E-15 75.5 TI23B_HUMAN reviewed Putative mitochondrial import inner membrane translocase subunit Tim23B TIMM23B Homo sapiens (Human) 257 protein import into mitochondrial matrix [GO:0030150] GO:0005744; GO:0015266; GO:0015450; GO:0030150; GO:0031305 0 0 0 PF02466; Q5U4X5 CHOYP_NDC80.2.3 m.61472 sp NDC80_XENTR 31.179 619 399 11 38 643 2 606 5.08E-86 285 NDC80_XENTR reviewed Kinetochore protein NDC80 homolog (Kinetochore protein Hec1) (Kinetochore-associated protein 2) ndc80 kntc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 640 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; mitotic spindle organization [GO:0007052] GO:0000132; GO:0000776; GO:0000777; GO:0000778; GO:0005200; GO:0007052; GO:0007059; GO:0031262; GO:0051301; GO:0051315 0 0 0 PF03801; Q6PIF2 CHOYP_BRAFLDRAFT_69975.1.1 m.46090 sp SYCE2_HUMAN 26.374 91 67 0 67 157 70 160 5.08E-08 53.5 SYCE2_HUMAN reviewed Synaptonemal complex central element protein 2 (Central element synaptonemal complex protein 1) SYCE2 CESC1 Homo sapiens (Human) 218 cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130] GO:0000801; GO:0007130; GO:0051301 0 0 0 0 Q99828 CHOYP_BRAFLDRAFT_125227.2.2 m.58044 sp CIB1_HUMAN 45.55 191 97 3 37 220 1 191 5.08E-54 174 CIB1_HUMAN reviewed Calcium and integrin-binding protein 1 (CIB) (Calcium- and integrin-binding protein) (CIBP) (Calmyrin) (DNA-PKcs-interacting protein) (Kinase-interacting protein) (KIP) (SNK-interacting protein 2-28) (SIP2-28) CIB1 CIB KIP PRKDCIP Homo sapiens (Human) 191 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to growth factor stimulus [GO:0071363]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; cytoplasmic microtubule organization [GO:0031122]; double-strand break repair [GO:0006302]; endomitotic cell cycle [GO:0007113]; extrinsic apoptotic signaling pathway [GO:0097191]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of megakaryocyte differentiation [GO:0045653]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; platelet formation [GO:0030220]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of cell growth [GO:0030307]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of male germ cell proliferation [GO:2000256]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of cell division [GO:0051302]; regulation of cell proliferation [GO:0042127]; response to ischemia [GO:0002931]; spermatid development [GO:0007286]; thrombopoietin-mediated signaling pathway [GO:0038163] GO:0001525; GO:0001933; GO:0001934; GO:0001954; GO:0002931; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005794; GO:0005813; GO:0005886; GO:0006302; GO:0006915; GO:0006974; GO:0007026; GO:0007113; GO:0007155; GO:0007286; GO:0008284; GO:0008285; GO:0008427; GO:0010977; GO:0016020; GO:0016324; GO:0017016; GO:0030027; GO:0030220; GO:0030291; GO:0030307; GO:0030335; GO:0030424; GO:0030425; GO:0030426; GO:0031122; GO:0031982; GO:0032433; GO:0032587; GO:0033630; GO:0038163; GO:0042127; GO:0042383; GO:0043005; GO:0043025; GO:0043066; GO:0043085; GO:0043495; GO:0045653; GO:0048471; GO:0051092; GO:0051301; GO:0051302; GO:0051898; GO:0070062; GO:0070374; GO:0070886; GO:0071356; GO:0071363; GO:0071902; GO:0071944; GO:0090004; GO:0090050; GO:0090314; GO:0097191; GO:1900026; GO:1990090; GO:2000256 0 0 0 PF13499; Q9DFQ7 CHOYP_IDLC.1.1 m.63623 sp RL24_GILMI 75.63 119 29 0 1 119 1 119 5.08E-64 194 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; A6H6E2 CHOYP_MMRN2.3.3 m.43940 sp MMRN2_MOUSE 31.061 132 81 3 88 219 819 940 5.09E-10 62 MMRN2_MOUSE reviewed Multimerin-2 Mmrn2 Mus musculus (Mouse) 943 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; O01393 CHOYP_LOC100533353.1.1 m.22529 sp UNC9_CAEEL 39.788 377 218 3 76 452 12 379 5.09E-102 313 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; P27512 CHOYP_TSP_05323.1.1 m.66498 sp TNR5_MOUSE 30.688 189 120 5 22 209 27 205 5.09E-17 80.5 TNR5_MOUSE reviewed Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CD antigen CD40) Cd40 Tnfrsf5 Mus musculus (Mouse) 289 apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cellular calcium ion homeostasis [GO:0006874]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of GTPase activity [GO:0043547]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tyrosine phosphorylation of Stat1 protein [GO:0042511]; protein kinase B signaling [GO:0043491]; regulation of apoptotic process [GO:0042981]; regulation of immune response [GO:0050776]; regulation of immunoglobulin secretion [GO:0051023]; response to lipopolysaccharide [GO:0032496] GO:0001934; GO:0002768; GO:0003823; GO:0005031; GO:0005615; GO:0005737; GO:0005886; GO:0006874; GO:0006954; GO:0009897; GO:0009986; GO:0019899; GO:0030890; GO:0031625; GO:0032496; GO:0032735; GO:0035631; GO:0042113; GO:0042511; GO:0042832; GO:0042981; GO:0043123; GO:0043231; GO:0043406; GO:0043410; GO:0043491; GO:0043547; GO:0045944; GO:0048304; GO:0050776; GO:0051023; GO:0051092; GO:0051607; GO:0070062; GO:0071222; GO:0071260; GO:0090037; GO:0097190; GO:2000353 0 0 cd13407; PF00020; P58374 CHOYP_LOC100207455.1.1 m.22703 sp RL30_BRABE 78.378 111 24 0 5 115 4 114 5.09E-62 187 RL30_BRABE reviewed 60S ribosomal protein L30 RPL30 Branchiostoma belcheri (Amphioxus) 114 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01248; P58727 CHOYP_TLR6.1.2 m.24581 sp TLR4_FELCA 26.622 447 274 15 338 757 400 819 5.09E-30 130 TLR4_FELCA reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Felis catus (Cat) (Felis silvestris catus) 833 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0001530; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005887; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF00560;PF13855;PF01582; Q09811 CHOYP_PGTG_04598.1.1 m.65229 sp HUS2_SCHPO 30.519 154 96 3 5 147 506 659 5.09E-14 71.2 HUS2_SCHPO reviewed ATP-dependent DNA helicase hus2/rqh1 (EC 3.6.4.12) rqh1 hus2 rad12 rec9 SPAC2G11.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1328 cellular response to DNA damage stimulus [GO:0006974]; DNA duplex unwinding [GO:0032508]; double-strand break repair via homologous recombination [GO:0000724]; intra-S DNA damage checkpoint [GO:0031573]; maintenance of rDNA [GO:0043007]; mitotic recombination-dependent replication fork processing [GO:1990426]; postreplication repair [GO:0006301]; recombinational repair [GO:0000725]; regulation of mitotic recombination involved in replication fork processing [GO:1903221]; replication fork processing at rDNA locus [GO:0034065]; resolution of mitotic recombination intermediates [GO:0071140]; telomere maintenance [GO:0000723]; UV-damage excision repair [GO:0070914] GO:0000228; GO:0000723; GO:0000724; GO:0000725; GO:0003677; GO:0005524; GO:0005730; GO:0005737; GO:0006301; GO:0006974; GO:0009378; GO:0031422; GO:0031573; GO:0032508; GO:0034065; GO:0035861; GO:0043007; GO:0043140; GO:0070914; GO:0071140; GO:1903221; GO:1990426 0 0 0 PF00270;PF00271;PF00570;PF16124;PF09382; Q3A8Q0 CHOYP_NEMVEDRAFT_V1G194582.1.2 m.11443 sp PDXT_CARHZ 43.779 217 94 7 13 228 1 190 5.09E-50 164 PDXT_CARHZ reviewed Pyridoxal 5'-phosphate synthase subunit PdxT (EC 4.3.3.6) (Pdx2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) pdxT CHY_2702 Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) 191 glutamine catabolic process [GO:0006543]; pyridoxal phosphate biosynthetic process [GO:0042823]; vitamin B6 biosynthetic process [GO:0042819] GO:0004359; GO:0006543; GO:0036381; GO:0042819; GO:0042823 PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01615}. 0 cd01749; PF01174; Q4UMH6 CHOYP_LOC100892569.1.1 m.46708 sp Y381_RICFE 28.66 321 207 9 206 522 831 1133 5.09E-24 110 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q642H9 CHOYP_RS4.4.11 m.16202 sp RS4X_DANRE 76.786 168 39 0 4 171 3 170 5.09E-92 272 RS4X_DANRE reviewed "40S ribosomal protein S4, X isoform" rps4x rps4 zgc:92076 Danio rerio (Zebrafish) (Brachydanio rerio) 263 brain development [GO:0007420]; chordate embryonic development [GO:0043009]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0007420; GO:0019843; GO:0022627; GO:0043009 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q8NHV1 CHOYP_LOC100331400.2.2 m.60971 sp GIMA7_HUMAN 35.021 237 134 5 310 541 1 222 5.09E-41 154 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8R059 CHOYP_LOC100562252.1.1 m.61548 sp GALE_MOUSE 65.724 283 91 2 6 282 4 286 5.09E-143 411 GALE_MOUSE reviewed UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-galactose 4-epimerase) Gale Mus musculus (Mouse) 347 galactose catabolic process [GO:0019388]; galactose catabolic process via UDP-galactose [GO:0033499]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623] GO:0003974; GO:0003978; GO:0006012; GO:0019388; GO:0033499; GO:0042803; GO:0061623; GO:0070062 PATHWAY: Carbohydrate metabolism; galactose metabolism. 0 0 PF16363; Q93212 CHOYP_LOC100748598.1.1 m.25151 sp SOL1_CAEEL 24.561 570 363 24 55 601 28 553 5.09E-27 119 SOL1_CAEEL reviewed Suppressor of lurcher protein 1 sol-1 C15A11.3 Caenorhabditis elegans 594 "adult locomotory behavior [GO:0008344]; hyperosmotic response [GO:0006972]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of locomotion [GO:0040012]; thigmotaxis [GO:0001966]" GO:0001966; GO:0005886; GO:0006972; GO:0008328; GO:0008344; GO:0016247; GO:0030054; GO:0032589; GO:0040012; GO:0045202; GO:0045211; GO:0051968 0 0 0 PF00431; Q99M80 CHOYP_PTPRT.4.45 m.8814 sp PTPRT_MOUSE 30.352 738 464 17 422 1131 738 1453 5.09E-85 306 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9D5V6 CHOYP_SYAP1.1.1 m.22473 sp SYAP1_MOUSE 50.376 266 110 5 81 327 65 327 5.09E-74 238 SYAP1_MOUSE reviewed Synapse-associated protein 1 Syap1 Mus musculus (Mouse) 365 0 GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0070062 0 0 0 PF03909; Q9VCA2 CHOYP_DWIL_GK11736.1.1 m.65581 sp ORCT_DROME 35.428 573 330 11 1 559 1 547 5.09E-108 337 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9Y7Y3 CHOYP_LOC580669.1.1 m.7758 sp YGR4_SCHPO 48.485 99 49 1 112 208 91 189 5.09E-22 93.2 YGR4_SCHPO reviewed Uncharacterized RNA-binding protein C365.04c SPBC365.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 233 ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254] GO:0000166; GO:0003723; GO:0005634; GO:0005730; GO:0019843; GO:0030686; GO:0042254; GO:0042274 0 0 0 PF00076; O75382 CHOYP_BRAFLDRAFT_84664.5.7 m.53877 sp TRIM3_HUMAN 26.667 165 111 5 149 305 578 740 5.10E-07 54.7 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P27465 CHOYP_PISD.1.2 m.2775 sp PISD_CRIGR 50.968 310 138 4 87 391 108 408 5.10E-107 323 PISD_CRIGR reviewed "Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]" Pisd PSSC Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 409 phosphatidylethanolamine biosynthetic process [GO:0006646]; protein autoprocessing [GO:0016540] GO:0004609; GO:0006646; GO:0016540; GO:0031305 0 0 0 PF02666; P83425 CHOYP_BRAFLDRAFT_69134.10.13 m.57248 sp HIP_MYTED 30.476 105 72 1 51 155 85 188 5.10E-09 56.2 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q10010 CHOYP_BRAFLDRAFT_124948.1.1 m.19871 sp YSV4_CAEEL 44.33 97 54 0 2 98 61 157 5.10E-27 107 YSV4_CAEEL reviewed Uncharacterized protein T19C3.4 T19C3.4 Caenorhabditis elegans 229 0 GO:0016021 0 0 0 PF03134; Q497B8 CHOYP_NEMVEDRAFT_V1G245101.1.1 m.56451 sp KDM8_RAT 31.193 218 134 7 49 254 189 402 5.10E-21 97.8 KDM8_RAT reviewed Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) Kdm8 Jmjd5 Rattus norvegicus (Rat) 414 "G2/M transition of mitotic cell cycle [GO:0000086]; histone H3-K36 demethylation [GO:0070544]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0003682; GO:0005634; GO:0006351; GO:0045893; GO:0046872; GO:0051864; GO:0070544 0 0 0 0 Q502M6 CHOYP_LOC755521.27.28 m.61132 sp ANR29_DANRE 41.722 151 87 1 4 154 116 265 5.10E-29 110 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q60953 CHOYP_LOC100377759.4.15 m.13102 sp PML_MOUSE 25.896 251 138 8 83 327 621 829 5.10E-06 52 PML_MOUSE reviewed Protein PML Pml Mus musculus (Mouse) 885 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell aging [GO:0007569]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of interleukin-1 secretion [GO:0050711]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of MHC class I biosynthetic process [GO:0045345]; positive regulation of telomere maintenance [GO:0032206]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0007569; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045345; GO:0045892; GO:0045944; GO:0046332; GO:0048146; GO:0048384; GO:0050711; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060444; GO:0070059; GO:0071353; GO:0072332; GO:0090398; GO:0097191; GO:1902187; GO:2000059; GO:2000779; GO:2001235; GO:2001238 0 0 0 PF12126;PF00643; Q68FD7 CHOYP_FNIP1.1.1 m.23640 sp FNIP1_MOUSE 40.741 540 231 20 38 509 32 550 5.10E-98 338 FNIP1_MOUSE reviewed Folliculin-interacting protein 1 Fnip1 Kiaa1961 Mus musculus (Mouse) 1165 cellular response to starvation [GO:0009267]; immature B cell differentiation [GO:0002327]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of B cell apoptotic process [GO:0002904]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein phosphorylation [GO:0001934]; regulation of pro-B cell differentiation [GO:2000973]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] GO:0000122; GO:0001932; GO:0001934; GO:0002327; GO:0002904; GO:0005085; GO:0005737; GO:0009267; GO:0031334; GO:0031929; GO:0032007; GO:0033138; GO:0043154; GO:2000973 0 0 0 PF14638;PF14637;PF14636; Q8BRG8 CHOYP_LOC100377657.1.1 m.10723 sp TM209_MOUSE 38.486 621 285 15 29 643 30 559 5.10E-131 399 TM209_MOUSE reviewed Transmembrane protein 209 Tmem209 Mus musculus (Mouse) 561 0 GO:0016021 0 0 0 PF09786; Q90XD2 CHOYP_LOC100180543.1.1 m.4746 sp SPEB_CHICK 62.908 337 122 1 19 352 4 340 5.10E-160 454 SPEB_CHICK reviewed "Agmatinase, mitochondrial (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH)" AGMAT Gallus gallus (Chicken) 340 putrescine biosynthetic process from arginine [GO:0033388]; spermidine biosynthetic process [GO:0008295] GO:0005739; GO:0008295; GO:0008783; GO:0033388; GO:0046872; GO:0070062 PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. {ECO:0000250|UniProtKB:Q9BSE5}. 0 0 PF00491; Q99M80 CHOYP_PTPRT.41.45 m.61846 sp PTPRT_MOUSE 30.337 178 115 4 1 172 1132 1306 5.10E-13 72.4 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; A8XZB0 CHOYP_contig_054901 m.65508 sp ATIF2_CAEBR 53.521 71 33 0 61 131 32 102 5.11E-17 74.3 ATIF2_CAEBR reviewed "ATPase inhibitor mai-2, mitochondrial" mai-2 CBG21048 Caenorhabditis briggsae 109 heme biosynthetic process [GO:0006783]; negative regulation of ATPase activity [GO:0032780] GO:0005739; GO:0006783; GO:0032780; GO:0042030; GO:0051117 0 0 0 PF04568; G5E8P0 CHOYP_TUBGCP6.1.1 m.54124 sp GCP6_MOUSE 32.25 831 501 19 13 803 3 811 5.11E-112 395 GCP6_MOUSE reviewed Gamma-tubulin complex component 6 (GCP-6) Tubgcp6 Kiaa1669 Mus musculus (Mouse) 1769 centrosome duplication [GO:0051298]; cytoplasmic microtubule organization [GO:0031122]; interphase microtubule nucleation by interphase microtubule organizing center [GO:0051415]; meiotic nuclear division [GO:0007126]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307] GO:0000922; GO:0000923; GO:0005200; GO:0005813; GO:0005874; GO:0007020; GO:0007126; GO:0008017; GO:0008274; GO:0016020; GO:0031122; GO:0043015; GO:0051298; GO:0051415; GO:0070062; GO:0090307 0 0 0 PF04130; O43734 CHOYP_LOC100157000.1.1 m.34246 sp CIKS_HUMAN 31.25 112 67 4 237 345 450 554 5.11E-11 67.4 CIKS_HUMAN reviewed Adapter protein CIKS (Connection to IKK and SAPK/JNK) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) TRAF3IP2 C6orf2 C6orf4 C6orf5 C6orf6 Homo sapiens (Human) 574 B cell apoptotic process [GO:0001783]; humoral immune response [GO:0006959]; immunoglobulin secretion [GO:0048305]; intracellular signal transduction [GO:0035556]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0001783; GO:0002230; GO:0005622; GO:0006959; GO:0035556; GO:0043123; GO:0048305 0 0 0 PF08357; P17810 CHOYP_LOC100369131.1.2 m.45133 sp PRPH2_BOVIN 25.839 298 203 6 4 285 4 299 5.11E-38 142 PRPH2_BOVIN reviewed Peripherin-2 (Retinal degeneration slow protein) PRPH2 RDS Bos taurus (Bovine) 345 cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; visual perception [GO:0007601] GO:0005887; GO:0007155; GO:0007166; GO:0007601 0 0 0 PF00335; P18101 CHOYP_RL40.3.7 m.22665 sp RL40_DROME 96.094 128 5 0 1 128 1 128 5.11E-89 256 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; P20481 CHOYP_AFURIN2.1.1 m.59866 sp BUCC_APLCA 62.5 48 17 1 63 110 335 381 5.11E-10 58.5 BUCC_APLCA reviewed Buccalin [Cleaved into: Buccalin-D; Buccalin-E; Buccalin-F; Buccalin-G; Buccalin-H; Buccalin-A; Buccalin-I; Buccalin-J; Buccalin-K; Buccalin-L; Buccalin-B (BUCb); Buccalin-M; Buccalin gene-predicted acidic peptide A (BGPAP A); Buccalin-N; Buccalin-O; Buccalin-P; Buccalin-Q; Buccalin-R; Buccalin-C; Buccalin-S; Buccalin gene-predicted acidic peptide B (BGPAP B)] 0 Aplysia californica (California sea hare) 505 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 0 P29590 CHOYP_LOC100377759.15.15 m.64824 sp PML_HUMAN 26.222 225 138 6 98 318 621 821 5.11E-09 61.2 PML_HUMAN reviewed Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) 882 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006915; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0016925; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045892; GO:0045930; GO:0046982; GO:0048146; GO:0048384; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060333; GO:0060444; GO:0070059; GO:0071353; GO:0090398; GO:0097191; GO:1901796; GO:1902187; GO:1904816; GO:2000059; GO:2000779; GO:2001238 0 0 0 PF12126;PF00643; P62864 CHOYP_MGC89853.1.7 m.7189 sp RS30_RAT 86.441 59 8 0 105 163 1 59 5.11E-21 84 RS30_RAT reviewed 40S ribosomal protein S30 Fau Rattus norvegicus (Rat) 59 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF04758; P78559 CHOYP_NEMVEDRAFT_V1G106168.1.1 m.35433 sp MAP1A_HUMAN 32.168 143 87 3 316 455 1360 1495 5.11E-15 81.6 MAP1A_HUMAN reviewed Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] MAP1A MAP1L Homo sapiens (Human) 2803 microtubule cytoskeleton organization [GO:0000226]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0000226; GO:0002230; GO:0005198; GO:0005737; GO:0005874; GO:0005875; GO:0007026; GO:0098779; GO:0098792 0 0 0 0 P87132 CHOYP_SMP_076400.1.2 m.27788 sp YFK5_SCHPO 27.607 163 101 4 2 161 423 571 5.11E-09 57.4 YFK5_SCHPO reviewed Uncharacterized protein C167.05 SPAC167.05 SPAC57A7.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 601 response to stress [GO:0006950] GO:0005829; GO:0006950 0 0 0 PF00582; Q06852 CHOYP_043R.1.5 m.16874 sp SLAP1_CLOTH 56.944 216 61 18 10 197 1388 1599 5.11E-08 55.8 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q0P4Y8 CHOYP_LOC100864539.1.1 m.9375 sp LMF2_XENTR 47.248 218 107 4 1 214 399 612 5.11E-58 199 LMF2_XENTR reviewed Lipase maturation factor 2 lmf2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 707 0 GO:0005789; GO:0016021 0 0 0 PF06762; Q28298 CHOYP_LOC100369294.4.6 m.28261 sp RRBP1_CANLF 27.479 706 380 20 217 899 785 1381 5.11E-26 119 RRBP1_CANLF reviewed Ribosome-binding protein 1 (180 kDa ribosome receptor) (RRp) RRBP1 P180 Canis lupus familiaris (Dog) (Canis familiaris) 1534 protein transport [GO:0015031]; signal transduction [GO:0007165]; translation [GO:0006412] GO:0004872; GO:0005840; GO:0006412; GO:0007165; GO:0015031; GO:0030176 0 0 0 PF05104; Q55E58 CHOYP_TRIADDRAFT_57945.1.3 m.9119 sp PATS1_DICDI 31.827 531 327 10 1 499 1692 2219 5.11E-78 275 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q64127 CHOYP_LOC100373444.7.79 m.3209 sp TIF1A_MOUSE 26.923 208 138 6 26 222 175 379 5.11E-07 55.1 TIF1A_MOUSE reviewed Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 6.3.2.-) (E3 ubiquitin-protein ligase Trim24) (Tripartite motif-containing protein 24) Trim24 Tif1 Tif1a Mus musculus (Mouse) 1051 "calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; transcription, DNA-templated [GO:0006351]" GO:0002039; GO:0003682; GO:0003713; GO:0004672; GO:0004842; GO:0005634; GO:0005719; GO:0005726; GO:0005737; GO:0006351; GO:0006468; GO:0008270; GO:0008285; GO:0010628; GO:0016567; GO:0016874; GO:0016922; GO:0030163; GO:0031647; GO:0034056; GO:0042981; GO:0043565; GO:0045892; GO:0045893; GO:0046777; GO:0055074; GO:0061630; GO:0070562; GO:0070577; GO:0071391; GO:1901796 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643; Q6IMN6 CHOYP_LOC101165018.5.5 m.63087 sp CAPR2_HUMAN 30.631 111 68 4 248 352 994 1101 5.11E-07 55.5 CAPR2_HUMAN reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (Gastric cancer multidrug resistance-associated protein) (Protein EEG-1) (RNA granule protein 140) CAPRIN2 C1QDC1 EEG1 KIAA1873 RNG140 Homo sapiens (Human) 1127 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q6PFY8 CHOYP_TRI45.15.23 m.39319 sp TRI45_MOUSE 23.827 277 167 10 6 253 133 394 5.11E-07 55.1 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6W5P4 CHOYP_NPSR1.1.2 m.22461 sp NPSR1_HUMAN 26.667 270 164 11 24 287 31 272 5.11E-06 52.4 NPSR1_HUMAN reviewed Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) (G-protein coupled receptor for asthma susceptibility) NPSR1 GPR154 GPRA PGR14 Homo sapiens (Human) 371 neuropeptide signaling pathway [GO:0007218]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281] GO:0005000; GO:0005737; GO:0005886; GO:0005887; GO:0007218; GO:0008188; GO:0051281 0 0 0 PF00001; Q7ZV22 CHOYP_MTAP.1.1 m.15433 sp MTAP_DANRE 64.706 272 96 0 11 282 7 278 5.11E-134 383 MTAP_DANRE reviewed S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) mtap zgc:66012 Danio rerio (Zebrafish) (Brachydanio rerio) 280 L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; purine-containing compound salvage [GO:0043101]; purine ribonucleoside salvage [GO:0006166] GO:0005634; GO:0005737; GO:0006166; GO:0017061; GO:0019509; GO:0043101 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_03155}. 0 0 PF01048; Q7ZVC9 CHOYP_BRAFLDRAFT_249141.1.1 m.6974 sp SMAP_DANRE 37.576 165 84 5 33 193 22 171 5.11E-25 98.6 SMAP_DANRE reviewed Small acidic protein smap zgc:56106 Danio rerio (Zebrafish) (Brachydanio rerio) 171 0 0 0 0 0 PF15477; Q80V70 CHOYP_MEG10.34.91 m.38624 sp MEGF6_MOUSE 37.681 207 102 9 197 403 1033 1212 5.11E-24 109 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8BMG8 CHOYP_DMOJ_GI19815.1.1 m.35416 sp MFTC_MOUSE 53.821 301 131 3 18 318 17 309 5.11E-108 320 MFTC_MOUSE reviewed Mitochondrial folate transporter/carrier (Solute carrier family 25 member 32) Slc25a32 Mftc Mus musculus (Mouse) 316 glycine metabolic process [GO:0006544]; translation [GO:0006412]; transport [GO:0006810] GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0006544; GO:0006810; GO:0016021 0 0 0 PF00153; Q90773 CHOYP_LOC663736.2.2 m.31452 sp CEPU1_CHICK 32.372 312 186 11 9 317 21 310 5.11E-31 124 CEPU1_CHICK reviewed Protein CEPU-1 0 Gallus gallus (Chicken) 353 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225 0 0 0 PF07679;PF00047; Q99NH0 CHOYP_LOC762964.6.10 m.39980 sp ANR17_MOUSE 33 500 280 17 273 755 224 685 5.11E-54 206 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BYD6 CHOYP_LOC100122067.1.1 m.49811 sp RM01_HUMAN 27.099 262 163 11 72 326 70 310 5.11E-11 66.6 RM01_HUMAN reviewed "39S ribosomal protein L1, mitochondrial (L1mt) (MRP-L1)" MRPL1 BM-022 Homo sapiens (Human) 325 maturation of LSU-rRNA [GO:0000470]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0015934; GO:0044822; GO:0070125; GO:0070126 0 0 cd00403; PF00687; Q9CQW0 CHOYP_LOC100369729.2.3 m.44256 sp EMC6_MOUSE 66.019 103 35 0 15 117 8 110 5.11E-39 129 EMC6_MOUSE reviewed ER membrane protein complex subunit 6 (Transmembrane protein 93) Emc6 Tmem93 Mus musculus (Mouse) 110 autophagosome assembly [GO:0000045]; protein folding in endoplasmic reticulum [GO:0034975] GO:0000045; GO:0016021; GO:0030176; GO:0034975; GO:0072546; GO:0097631 0 0 0 PF07019; Q9NQC3 CHOYP_SYWC.5.5 m.54889 sp RTN4_HUMAN 55.135 185 83 0 155 339 1006 1190 5.11E-70 239 RTN4_HUMAN reviewed Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) 1192 apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; cardiac epithelial to mesenchymal transition [GO:0060317]; cerebral cortex radial glia guided migration [GO:0021801]; endoplasmic reticulum tubular network assembly [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of axon extension [GO:0030517]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell growth [GO:0030308]; nuclear pore complex assembly [GO:0051292]; regulation of apoptotic process [GO:0042981]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of cell migration [GO:0030334] GO:0005622; GO:0005635; GO:0005783; GO:0005789; GO:0005886; GO:0005913; GO:0006915; GO:0007413; GO:0021801; GO:0030176; GO:0030308; GO:0030334; GO:0030517; GO:0042981; GO:0042995; GO:0044822; GO:0050771; GO:0051292; GO:0060317; GO:0070062; GO:0071786; GO:0071787; GO:0098641; GO:2000172 0 0 0 PF02453; O14522 CHOYP_PTPRZ.9.9 m.46959 sp PTPRT_HUMAN 30.556 576 372 11 198 749 869 1440 5.12E-76 271 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O89026 CHOYP_LOC100551893.1.1 m.20438 sp ROBO1_MOUSE 30.085 236 137 12 22 252 194 406 5.12E-10 63.9 ROBO1_MOUSE reviewed Roundabout homolog 1 Robo1 Dutt1 Mus musculus (Mouse) 1612 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; cell migration involved in sprouting angiogenesis [GO:0002042]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; coronary vasculature development [GO:0060976]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; olfactory bulb interneuron development [GO:0021891]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Rho protein signal transduction [GO:0035025]; Roundabout signaling pathway [GO:0035385]; ventricular septum development [GO:0003281] GO:0002042; GO:0003281; GO:0005737; GO:0005886; GO:0006919; GO:0007156; GO:0007411; GO:0007507; GO:0008285; GO:0009986; GO:0016021; GO:0016199; GO:0021836; GO:0021891; GO:0030275; GO:0030336; GO:0030673; GO:0033600; GO:0035025; GO:0035385; GO:0042802; GO:0050772; GO:0050925; GO:0060763; GO:0060976; GO:0070100 0 0 0 PF00041;PF07679; P02707 CHOYP_LOC100368595.2.3 m.43362 sp LECH_CHICK 35.156 128 80 3 374 499 78 204 5.12E-21 94.7 LECH_CHICK reviewed Hepatic lectin 0 Gallus gallus (Chicken) 207 endocytosis [GO:0006897] GO:0006897; GO:0016021; GO:0030246 0 0 0 PF00059; P19965 CHOYP_LOC100371381.2.2 m.6959 sp SP15_TETCF 29.651 172 101 6 93 260 112 267 5.12E-16 80.9 SP15_TETCF reviewed SITS-binding protein (SP105) 0 Tetronarce californica (Pacific electric ray) (Torpedo californica) 697 carbohydrate metabolic process [GO:0005975] GO:0004553; GO:0005975; GO:0016021 0 0 0 PF01055; Q12829 CHOYP_LOC100372140.1.1 m.17011 sp RB40B_HUMAN 62.774 274 86 4 9 266 5 278 5.12E-123 354 RB40B_HUMAN reviewed Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Protein Rar) RAB40B SEC4L Homo sapiens (Human) 278 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264]; symbiont intracellular protein transport in host [GO:0030581] GO:0005525; GO:0005635; GO:0005886; GO:0007264; GO:0016567; GO:0030581; GO:0043657; GO:0048471 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00071;PF07525; Q13107 CHOYP_LOC100369578.1.1 m.6663 sp UBP4_HUMAN 40.828 169 94 2 1087 1251 757 923 5.12E-36 152 UBP4_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog) USP4 UNP UNPH Homo sapiens (Human) 963 negative regulation of protein ubiquitination [GO:0031397]; protein deubiquitination [GO:0016579]; protein localization to cell surface [GO:0034394]; regulation of protein stability [GO:0031647]; spliceosomal tri-snRNP complex assembly [GO:0000244]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000244; GO:0004843; GO:0005634; GO:0005737; GO:0005764; GO:0005886; GO:0006511; GO:0016579; GO:0031397; GO:0031647; GO:0031685; GO:0034394; GO:0042802; GO:0046872 0 0 0 PF06337;PF14836;PF00443; Q1JP79 CHOYP_ARC1A.1.1 m.56263 sp ARC1A_BOVIN 62.5 152 57 0 1 152 1 152 5.12E-64 203 ARC1A_BOVIN reviewed Actin-related protein 2/3 complex subunit 1A ARPC1A Bos taurus (Bovine) 370 Arp2/3 complex-mediated actin nucleation [GO:0034314] GO:0005737; GO:0005885; GO:0034314; GO:0036195; GO:0051015; GO:0070062 0 0 0 PF00400; Q3ZC84 CHOYP_CNDP2.2.4 m.25846 sp CNDP2_BOVIN 74.556 169 43 0 1 169 305 473 5.12E-91 276 CNDP2_BOVIN reviewed Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) CNDP2 Bos taurus (Bovine) 475 peptide catabolic process [GO:0043171] GO:0004180; GO:0005654; GO:0005737; GO:0008270; GO:0043171; GO:0070062; GO:0070573; GO:0102008 0 0 cd05676; PF07687;PF01546; Q49A92 CHOYP_NEMVEDRAFT_V1G215851.2.2 m.18129 sp CH034_HUMAN 29.684 411 224 17 19 385 1 390 5.12E-22 102 CH034_HUMAN reviewed Uncharacterized protein C8orf34 (Protein VEST-1) C8orf34 Homo sapiens (Human) 452 0 0 0 0 0 0 Q4VBS4 CHOYP_AGAP_AGAP007120.1.1 m.57543 sp MAP12_DANRE 50 122 57 1 34 155 183 300 5.12E-32 119 MAP12_DANRE reviewed "Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D)" metap1d map1d zgc:110461 Danio rerio (Zebrafish) (Brachydanio rerio) 338 protein initiator methionine removal [GO:0070084] GO:0005739; GO:0046872; GO:0070006; GO:0070084 0 0 cd01086; PF00557; Q58DT1 CHOYP_RL7.1.2 m.38623 sp RL7_BOVIN 74.011 177 46 0 1 177 71 247 5.12E-94 276 RL7_BOVIN reviewed 60S ribosomal protein L7 RPL7 Bos taurus (Bovine) 248 "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" GO:0000463; GO:0002181; GO:0003735; GO:0022625; GO:0044822 0 0 0 PF00327;PF08079; Q58DT1 CHOYP_RL7.2.2 m.57459 sp RL7_BOVIN 74.011 177 46 0 1 177 71 247 5.12E-94 276 RL7_BOVIN reviewed 60S ribosomal protein L7 RPL7 Bos taurus (Bovine) 248 "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]" GO:0000463; GO:0002181; GO:0003735; GO:0022625; GO:0044822 0 0 0 PF00327;PF08079; Q5BIM1 CHOYP_BRAFLDRAFT_88224.5.11 m.31855 sp TRI45_BOVIN 22.039 304 190 12 18 304 90 363 5.12E-08 59.7 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6DDK1 CHOYP_MUC1.2.5 m.10887 sp CREST_XENLA 65.823 79 24 3 1 78 1 77 5.12E-24 106 CREST_XENLA reviewed Calcium-responsive transactivator (ss18-like protein 1) ss18l1 crest Xenopus laevis (African clawed frog) 403 "covalent chromatin modification [GO:0016569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0016569 0 0 0 PF05030; Q6YHU6 CHOYP_LOC416924.1.1 m.51120 sp THADA_HUMAN 25 1104 676 31 329 1326 359 1416 5.12E-66 252 THADA_HUMAN reviewed Thyroid adenoma-associated protein (Gene inducing thyroid adenomas protein) THADA GITA KIAA1767 Homo sapiens (Human) 1953 0 0 0 0 0 PF10350; Q8CA72 CHOYP_BRAFLDRAFT_214407.1.1 m.17277 sp GAN_MOUSE 35.117 598 346 10 23 611 11 575 5.12E-112 351 GAN_MOUSE reviewed Gigaxonin Gan Mus musculus (Mouse) 597 cytoskeleton organization [GO:0007010]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005737; GO:0005856; GO:0007010; GO:0016567; GO:0031463; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H2C0}. 0 0 PF07707;PF00651;PF01344; Q8IW40 CHOYP_BRAFLDRAFT_118362.1.1 m.10446 sp CC103_HUMAN 42.857 210 117 2 11 218 4 212 5.12E-52 171 CC103_HUMAN reviewed Coiled-coil domain-containing protein 103 CCDC103 Homo sapiens (Human) 242 axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; determination of digestive tract left/right asymmetry [GO:0071907]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; heart looping [GO:0001947]; inner dynein arm assembly [GO:0036159]; outer dynein arm assembly [GO:0036158] GO:0001947; GO:0003341; GO:0005737; GO:0005930; GO:0031514; GO:0036158; GO:0036159; GO:0042803; GO:0060287; GO:0070286; GO:0071907 0 0 0 PF15867;PF13877; Q8VE97 CHOYP_LOC100367051.1.1 m.13013 sp SRSF4_MOUSE 76.757 185 33 3 4 188 3 177 5.12E-92 284 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q8W485 CHOYP_LOC101163250.3.3 m.65692 sp Y5010_ARATH 42.609 115 66 0 35 149 74 188 5.12E-25 99 Y5010_ARATH reviewed "Uncharacterized protein At5g50100, mitochondrial" At5g50100 MPF21.11 Arabidopsis thaliana (Mouse-ear cress) 214 0 GO:0005739 0 0 0 PF04134; Q96DM1 CHOYP_LOC100498109.2.3 m.53613 sp PGBD4_HUMAN 28.173 323 192 12 1 298 275 582 5.12E-21 96.7 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q96DZ5 CHOYP_LOC100374091.1.1 m.26179 sp CLIP3_HUMAN 46.935 522 235 9 33 540 37 530 5.12E-154 458 CLIP3_HUMAN reviewed CAP-Gly domain-containing linker protein 3 (Cytoplasmic linker protein 170-related 59 kDa protein) (CLIP-170-related 59 kDa protein) (CLIPR-59) CLIP3 CLIPR59 Homo sapiens (Human) 547 chaperone-mediated protein transport [GO:0072321]; fat cell differentiation [GO:0045444]; membrane biogenesis [GO:0044091]; negative regulation of microtubule polymerization [GO:0031115]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endocytosis [GO:0045807]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose transport [GO:0010828]; positive regulation of protein phosphorylation [GO:0001934]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803] GO:0001934; GO:0005795; GO:0005802; GO:0005829; GO:0005886; GO:0008017; GO:0010803; GO:0010828; GO:0018230; GO:0031115; GO:0031901; GO:0032588; GO:0035594; GO:0043065; GO:0044091; GO:0045121; GO:0045444; GO:0045807; GO:0055038; GO:0072321; GO:0090004 0 0 0 PF12796;PF01302; Q9LQV2 CHOYP_BRAFLDRAFT_99723.6.9 m.52974 sp RDR1_ARATH 35.246 976 557 25 23 951 146 1093 5.12E-140 466 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; Q9UGM3 CHOYP_DMBT1.16.34 m.33435 sp DMBT1_HUMAN 43.22 590 257 11 1 517 508 1092 5.12E-126 409 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9VCA8 CHOYP_LOC589750.4.5 m.52144 sp ANKHM_DROME 29.651 516 297 14 1414 1917 546 1007 5.12E-41 171 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; A0JNH6 CHOYP_C102A.1.1 m.23591 sp C102A_BOVIN 48.554 484 198 9 50 483 66 548 5.13E-117 357 C102A_BOVIN reviewed Coiled-coil domain-containing protein 102A CCDC102A Bos taurus (Bovine) 555 0 GO:0003774; GO:0016459 0 0 0 PF01576; A2RV29 CHOYP_LOC410079.1.1 m.51060 sp ZN346_DANRE 36 75 44 1 146 216 182 256 5.13E-07 52.8 ZN346_DANRE reviewed Zinc finger protein 346 (Just another zinc finger protein) (Protein jaz) znf346 zgc:158750 Danio rerio (Zebrafish) (Brachydanio rerio) 301 intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332] GO:0002039; GO:0003725; GO:0005634; GO:0005737; GO:0008270; GO:0072332 0 0 0 PF12171; D2GXS7 CHOYP_BRAFLDRAFT_87292.3.6 m.23956 sp TRIM2_AILME 24.138 145 104 3 38 179 602 743 5.13E-07 52.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2A0P0 CHOYP_TFPI2.1.1 m.48021 sp KCP5_PINMG 39.669 121 60 5 117 228 47 163 5.13E-18 84 KCP5_PINMG reviewed BPTI/Kunitz domain-containing protein 5 (Nacre serine protease inhibitor 5) 0 Pinctada margaritifera (Black-lipped pearl oyster) 182 0 GO:0004867; GO:0005576 0 0 0 PF00014; O13395 CHOYP_CHS1.3.4 m.36831 sp CHS6_USTMA 26.849 365 191 12 592 943 573 874 5.13E-21 103 CHS6_USTMA reviewed Chitin synthase 6 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 6) (Class-V chitin synthase 6) CHS6 UMAG_10367 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 1180 cell wall organization [GO:0071555] GO:0003677; GO:0004100; GO:0005886; GO:0016021; GO:0030659; GO:0071555 0 0 0 PF00173;PF08766; P20816 CHOYP_BRAFLDRAFT_58592.2.2 m.4914 sp CP4A2_RAT 36.726 226 129 2 51 276 57 268 5.13E-40 148 CP4A2_RAT reviewed Cytochrome P450 4A2 (CYPIVA2) (Cytochrome P-450 K-2) (Cytochrome P450 K-5) (Cytochrome P450-LA-omega 2) (Lauric acid omega-hydroxylase) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.13.205) Cyp4a2 Cyp4a-2 Cyp4a11 Rattus norvegicus (Rat) 504 arachidonic acid metabolic process [GO:0019369]; icosanoid biosynthetic process [GO:0046456]; kidney development [GO:0001822]; lauric acid metabolic process [GO:0048252]; linoleic acid metabolic process [GO:0043651]; response to drug [GO:0042493]; response to hormone [GO:0009725] GO:0001822; GO:0005504; GO:0005506; GO:0005789; GO:0008391; GO:0008405; GO:0009725; GO:0018685; GO:0019369; GO:0020037; GO:0031090; GO:0042493; GO:0043231; GO:0043651; GO:0046456; GO:0048252; GO:0050544 0 0 0 PF00067; Q01765 CHOYP_EEF1A.2.3 m.20693 sp EF1A_PODCU 78.261 69 15 0 40 108 393 461 5.13E-29 111 EF1A_PODCU reviewed Elongation factor 1-alpha (EF-1-alpha) TEF Podospora curvicolla 461 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q01H84 CHOYP_SELN.1.1 m.31999 sp SELN_XENTR 43.272 379 195 8 138 509 70 435 5.13E-101 317 SELN_XENTR reviewed Selenoprotein N (SelN) sepn1 TEgg073a06.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 562 skeletal muscle fiber development [GO:0048741] GO:0005789; GO:0016021; GO:0016491; GO:0048741 0 0 0 0 Q18206 CHOYP_LOC100366518.6.6 m.65975 sp NAS36_CAEEL 31.564 358 220 17 161 507 141 484 5.13E-34 142 NAS36_CAEEL reviewed Zinc metalloproteinase nas-36 (EC 3.4.24.21) (Nematode astacin 36) nas-36 C26C6.3 Caenorhabditis elegans 617 "molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; multicellular organism development [GO:0007275]" GO:0004222; GO:0005576; GO:0007275; GO:0008270; GO:0018996 0 0 0 PF01400;PF00431;PF00090; Q6GNV7 CHOYP_TRIADDRAFT_60867.1.3 m.820 sp DIRC2_XENLA 38.261 115 68 1 1 112 341 455 5.13E-18 82 DIRC2_XENLA reviewed Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) 456 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6ZMQ8 CHOYP_LOC100679044.2.2 m.64055 sp LMTK1_HUMAN 35.952 420 215 16 7 409 32 414 5.13E-62 232 LMTK1_HUMAN reviewed Serine/threonine-protein kinase LMTK1 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (Lemur tyrosine kinase 1) (p35-binding protein) (p35BP) AATK AATYK KIAA0641 LMR1 LMTK1 Homo sapiens (Human) 1374 0 GO:0004674; GO:0005524; GO:0016021; GO:0048471 0 0 0 PF07714; Q8CAQ8 CHOYP_LOC586678.1.1 m.35070 sp MIC60_MOUSE 35.902 571 333 8 143 690 192 752 5.13E-105 339 MIC60_MOUSE reviewed MICOS complex subunit Mic60 (Mitochondrial inner membrane protein) (Mitofilin) Immt Mic60 Mus musculus (Mouse) 757 cristae formation [GO:0042407]; mitochondrial calcium ion homeostasis [GO:0051560] GO:0005739; GO:0005743; GO:0016020; GO:0042407; GO:0043209; GO:0044822; GO:0051560; GO:0061617 0 0 0 PF09731; Q8IFN0 CHOYP_contig_018371 m.21529 sp YD115_PLAF7 29.371 143 93 3 1 143 780 914 5.13E-06 52.4 YD115_PLAF7 reviewed Uncharacterized protein PFD1115c PFD1115c Plasmodium falciparum (isolate 3D7) 1612 0 GO:0016021 0 0 0 0 Q8N7X0 CHOYP_ADGB.1.3 m.22995 sp ADGB_HUMAN 40.82 561 278 15 15 547 35 569 5.13E-107 364 ADGB_HUMAN reviewed Androglobin (Calpain-7-like protein) ADGB C6orf103 CAPN7L Homo sapiens (Human) 1667 proteolysis [GO:0006508] GO:0004198; GO:0005737; GO:0006508; GO:0019825; GO:0020037 0 0 0 PF00648; Q8T2Q0 CHOYP_LOC100890020.1.1 m.36738 sp ZDHC6_DICDI 32.5 160 95 5 75 231 34 183 5.13E-08 58.9 ZDHC6_DICDI reviewed Putative ZDHHC-type palmitoyltransferase 6 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 6) DDB_G0275149 Dictyostelium discoideum (Slime mold) 698 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF00023;PF12796;PF01529; Q96MM6 CHOYP_LOC100374651.3.4 m.52010 sp HS12B_HUMAN 30.428 631 347 18 34 590 61 673 5.13E-94 306 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9H0J4 CHOYP_LOC100378873.2.3 m.16077 sp QRIC2_HUMAN 36.449 428 191 12 63 433 1251 1654 5.13E-70 245 QRIC2_HUMAN reviewed Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 0 0 0 0 0 PF16043; Q9JJ25 CHOYP_LOC100374741.17.83 m.20542 sp MEFV_RAT 25.389 193 113 5 12 204 404 565 5.13E-07 55.8 MEFV_RAT reviewed Pyrin (Marenostrin) Mefv Rattus norvegicus (Rat) 750 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; response to interferon-gamma [GO:0034341]; response to lipopolysaccharide [GO:0032496]; response to silicon dioxide [GO:0034021] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032496; GO:0034021; GO:0034341; GO:1900016; GO:1900226 0 0 0 PF02758;PF00643; Q9NZ94 CHOYP_CHLE.1.3 m.1676 sp NLGN3_HUMAN 30.245 367 206 9 9 341 201 551 5.13E-37 144 NLGN3_HUMAN reviewed Neuroligin-3 (Gliotactin homolog) NLGN3 KIAA1480 NL3 Homo sapiens (Human) 848 "adult behavior [GO:0030534]; axon extension [GO:0048675]; excitatory postsynaptic potential [GO:0060079]; inhibitory postsynaptic potential [GO:0060080]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; modulation of synaptic transmission [GO:0050804]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; oligodendrocyte differentiation [GO:0048709]; positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000969]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; receptor-mediated endocytosis [GO:0006898]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; regulation of terminal button organization [GO:2000331]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; visual learning [GO:0008542]; vocalization behavior [GO:0071625]" GO:0002087; GO:0004872; GO:0005887; GO:0006898; GO:0007158; GO:0007416; GO:0007612; GO:0008542; GO:0009986; GO:0030054; GO:0030139; GO:0030425; GO:0030534; GO:0035176; GO:0042043; GO:0043025; GO:0045202; GO:0048675; GO:0048709; GO:0050804; GO:0050808; GO:0050839; GO:0051965; GO:0051968; GO:0052689; GO:0060024; GO:0060076; GO:0060077; GO:0060079; GO:0060080; GO:0060291; GO:0060999; GO:0061002; GO:0071625; GO:0090394; GO:0097104; GO:0097105; GO:0097110; GO:0097151; GO:0098794; GO:1900271; GO:1902474; GO:2000310; GO:2000331; GO:2000463; GO:2000809; GO:2000969 0 0 0 PF00135; Q9UKN7 CHOYP_MYO20.1.1 m.7884 sp MYO15_HUMAN 29.337 784 457 22 7 770 1224 1930 5.13E-77 279 MYO15_HUMAN reviewed Unconventional myosin-XV (Unconventional myosin-15) MYO15A MYO15 Homo sapiens (Human) 3530 inner ear morphogenesis [GO:0042472]; locomotory behavior [GO:0007626]; sensory perception of sound [GO:0007605] GO:0003774; GO:0005524; GO:0005737; GO:0007605; GO:0007626; GO:0016459; GO:0032420; GO:0042472; GO:0070062 0 0 0 PF00373;PF00612;PF00063;PF00784;PF07653; Q9W6R5 CHOYP_HMCN2.11.12 m.51619 sp XLRS1_TAKRU 36.429 140 71 3 247 385 154 276 5.13E-22 100 XLRS1_TAKRU reviewed Retinoschisin (X-linked juvenile retinoschisis protein homolog) xlrs1 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 280 cell adhesion [GO:0007155] GO:0005576; GO:0007155 0 0 0 PF00754; A0JM12 CHOYP_CED1.4.29 m.23586 sp MEG10_XENTR 32.218 478 243 16 3 417 11 470 5.14E-50 190 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; O50655 CHOYP_LOC100373761.3.3 m.35341 sp XERD_SELRU 23.741 278 171 9 24 295 82 324 5.14E-08 57 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; P20478 CHOYP_GLNA2.4.4 m.64443 sp GLNA2_DROME 76.866 268 62 0 74 341 102 369 5.14E-161 457 GLNA2_DROME reviewed Glutamine synthetase 2 cytoplasmic (EC 6.3.1.2) (Glutamate--ammonia ligase 2) Gs2 CG1743 Drosophila melanogaster (Fruit fly) 369 glutamate catabolic process [GO:0006538]; glutamine biosynthetic process [GO:0006542]; neurotransmitter receptor metabolic process [GO:0045213]; synapse assembly [GO:0007416] GO:0004356; GO:0005524; GO:0005737; GO:0006538; GO:0006542; GO:0007416; GO:0045213 0 0 0 PF00120;PF03951; P24044 CHOYP_DICPUDRAFT_93011.1.1 m.30650 sp CALM_PLAFA 45.255 137 74 1 11 146 13 149 5.14E-35 121 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; P42262 CHOYP_GRIK2.1.3 m.33696 sp GRIA2_HUMAN 30.211 427 268 9 166 564 413 837 5.14E-57 209 GRIA2_HUMAN reviewed "Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)" GRIA2 GLUR2 Homo sapiens (Human) 883 chemical synaptic transmission [GO:0007268]; ionotropic glutamate receptor signaling pathway [GO:0035235]; signal transduction [GO:0007165] GO:0004970; GO:0004971; GO:0005231; GO:0005234; GO:0005789; GO:0005886; GO:0005887; GO:0007165; GO:0007268; GO:0030054; GO:0030666; GO:0032281; GO:0035235; GO:0045211 0 0 0 PF01094;PF00060;PF10613; Q04202 CHOYP_TCB2.2.2 m.35943 sp TCB2_CAEBR 25.651 269 182 5 77 336 11 270 5.14E-21 94 TCB2_CAEBR reviewed Transposable element Tcb2 transposase 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; Q06805 CHOYP_MEGF6.23.59 m.34455 sp TIE1_BOVIN 33.684 95 45 5 24 103 213 304 5.14E-10 58.5 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q08431 CHOYP_NEMVEDRAFT_V1G248463.1.1 m.46230 sp MFGM_HUMAN 29.187 209 116 10 170 351 22 225 5.14E-13 72.8 MFGM_HUMAN reviewed Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] MFGE8 Homo sapiens (Human) 387 "angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cellular protein metabolic process [GO:0044267]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of cell proliferation [GO:0008284]; response to estrogen [GO:0043627]; single fertilization [GO:0007338]; viral process [GO:0016032]" GO:0001525; GO:0001786; GO:0005576; GO:0005615; GO:0006910; GO:0006911; GO:0007155; GO:0007338; GO:0008284; GO:0008429; GO:0009897; GO:0016020; GO:0016032; GO:0019897; GO:0043627; GO:0044267; GO:0070062; GO:1903561; GO:2000427 0 0 0 PF00008;PF00754; Q09JW2 CHOYP_RL17.3.7 m.36827 sp RL17_ARGMO 79.72 143 29 0 1 143 1 143 5.14E-79 237 RL17_ARGMO reviewed 60S ribosomal protein L17 RpL17 Argas monolakensis (Mono lake bird tick) 185 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 cd00336; PF00237; Q24306 CHOYP_LOC100185951.1.1 m.35167 sp DIAP1_DROME 51.22 41 20 0 196 236 227 267 5.14E-06 50.1 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q502M6 CHOYP_TVAG_033450.1.4 m.21059 sp ANR29_DANRE 40.571 175 104 0 1 175 55 229 5.14E-36 129 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q502M6 CHOYP_TVAG_470020.5.8 m.24802 sp ANR29_DANRE 35.135 148 80 1 1 148 49 180 5.14E-19 84 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q55E31 CHOYP_NEMVEDRAFT_V1G245354.1.1 m.5223 sp RB32B_DICDI 56.944 216 78 3 13 225 56 259 5.14E-86 258 RB32B_DICDI reviewed Ras-related protein Rab-32B rab32B DDB_G0269416 Dictyostelium discoideum (Slime mold) 260 melanosome organization [GO:0032438]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005802; GO:0007264; GO:0032438; GO:0042470 0 0 0 PF00071; Q5FWI3 CHOYP_TMEM2.3.4 m.10491 sp TMEM2_MOUSE 30.616 1153 632 42 25 1087 111 1185 5.14E-133 441 TMEM2_MOUSE reviewed Transmembrane protein 2 Tmem2 Kiaa1412 Mus musculus (Mouse) 1383 multicellular organism development [GO:0007275] GO:0007275; GO:0016021; GO:0070062 0 0 0 PF10162; Q5IFJ8 CHOYP_BRAFLDRAFT_114978.1.1 m.43775 sp PSMD5_MACFA 35.197 483 309 3 26 504 20 502 5.14E-103 320 PSMD5_MACFA reviewed 26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B) PSMD5 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 504 proteasome assembly [GO:0043248] GO:0022624; GO:0043248 0 0 0 PF10508; Q6IRB2 CHOYP_BRAFLDRAFT_265744.1.1 m.52576 sp HES1A_XENLA 60.656 122 48 0 8 129 25 146 5.14E-47 164 HES1A_XENLA reviewed Transcription factor HES-1-A (Hairy and enhancer of split 1-A) (Protein hairy-1) (Xhairy-1) (Xhairy1) (Xlh1) hes1-a hairy1 Xenopus laevis (African clawed frog) 267 "multicellular organism development [GO:0007275]; negative regulation of muscle organ development [GO:0048635]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0006351; GO:0007219; GO:0007275; GO:0043425; GO:0043565; GO:0045892; GO:0046982; GO:0048635 0 0 0 PF07527;PF00010; Q6SJ93 CHOYP_NEMVEDRAFT_V1G233709.11.13 m.62982 sp F111B_HUMAN 22.449 294 182 9 668 938 438 708 5.14E-06 54.3 F111B_HUMAN reviewed Protein FAM111B (Cancer-associated nucleoprotein) FAM111B CANP Homo sapiens (Human) 734 0 0 0 0 0 0 Q7Z5L3 CHOYP_SMC2.2.4 m.21315 sp C1QL2_HUMAN 33.094 139 88 3 283 418 148 284 5.14E-12 69.7 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q8AXY6 CHOYP_ROR2.1.1 m.39984 sp MUSK_CHICK 39.45 218 117 4 32 239 315 527 5.14E-45 164 MUSK_CHICK reviewed "Muscle, skeletal receptor tyrosine protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)" MUSK Gallus gallus (Chicken) 947 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of synaptic growth at neuromuscular junction [GO:0008582] GO:0004714; GO:0005524; GO:0005886; GO:0007275; GO:0008582; GO:0016021; GO:0030054; GO:0030154; GO:0045211 0 0 0 PF01392;PF07679;PF00051;PF07714; Q8N5N7 CHOYP_PHUM_PHUM174810.1.1 m.31029 sp RM50_HUMAN 35.294 102 63 2 82 181 58 158 5.14E-16 76.3 RM50_HUMAN reviewed "39S ribosomal protein L50, mitochondrial (L50mt) (MRP-L50)" MRPL50 Homo sapiens (Human) 158 mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126] GO:0005743; GO:0005840; GO:0070125; GO:0070126 0 0 0 PF10501; Q8NB59 CHOYP_LOC100369472.1.2 m.54348 sp SYT14_HUMAN 50.689 363 157 3 190 546 209 555 5.14E-121 370 SYT14_HUMAN reviewed Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV) SYT14 Homo sapiens (Human) 555 vesicle fusion [GO:0006906] GO:0005509; GO:0005886; GO:0006906; GO:0016021; GO:0019905; GO:0030276 0 0 0 PF00168; Q96DM1 CHOYP_LOC100878126.1.1 m.59768 sp PGBD4_HUMAN 27.078 373 238 12 56 407 222 581 5.14E-29 122 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9C005 CHOYP_BRAFLDRAFT_202721.2.2 m.49541 sp DPY30_HUMAN 71.233 73 20 1 40 112 25 96 5.14E-29 103 DPY30_HUMAN reviewed Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) DPY30 Homo sapiens (Human) 99 "chromatin silencing at telomere [GO:0006348]; endosomal transport [GO:0016197]; histone H3-K4 methylation [GO:0051568]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005654; GO:0005794; GO:0005802; GO:0006348; GO:0006351; GO:0016197; GO:0018024; GO:0035097; GO:0042802; GO:0042803; GO:0044666; GO:0048188; GO:0051568 0 0 0 PF05186; Q9NYC9 CHOYP_BRAFLDRAFT_108792.5.5 m.64342 sp DYH9_HUMAN 32.588 313 181 4 654 966 1774 2056 5.14E-49 196 DYH9_HUMAN reviewed "Dynein heavy chain 9, axonemal (Axonemal beta dynein heavy chain 9) (Ciliary dynein heavy chain 9)" DNAH9 DNAH17L DNAL1 KIAA0357 Homo sapiens (Human) 4486 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018]; movement of cell or subcellular component [GO:0006928]; spermatogenesis [GO:0007283] GO:0003774; GO:0003777; GO:0005524; GO:0005737; GO:0005856; GO:0005874; GO:0005930; GO:0006928; GO:0007018; GO:0007283; GO:0016887; GO:0030030; GO:0030286 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; A3KG59 CHOYP_PM20D2.1.1 m.27186 sp P20D2_MOUSE 52.723 404 180 5 4 396 22 425 5.15E-129 380 P20D2_MOUSE reviewed Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) Pm20d2 Acy1l2 Gm424 Mus musculus (Mouse) 431 proteolysis [GO:0006508]; regulation of cellular protein metabolic process [GO:0032268] GO:0005654; GO:0006508; GO:0016805; GO:0032268; GO:0070062 0 0 0 PF07687;PF01546; E1BD59 CHOYP_TRI45.5.23 m.14695 sp TRI56_BOVIN 26.46 291 178 8 6 268 11 293 5.15E-23 105 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; E1BJS7 CHOYP_LOC100374741.70.83 m.60165 sp LIN41_BOVIN 25.161 155 101 8 26 174 278 423 5.15E-06 50.8 LIN41_BOVIN reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Bos taurus (Bovine) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; E7EXT2 CHOYP_UVSSA.1.1 m.8883 sp UVSSA_DANRE 38.623 523 285 9 351 857 218 720 5.15E-84 287 UVSSA_DANRE reviewed UV-stimulated scaffold protein A uvssa si:dkey-18h19.2 Danio rerio (Zebrafish) (Brachydanio rerio) 721 protein ubiquitination [GO:0016567]; response to UV [GO:0009411]; transcription-coupled nucleotide-excision repair [GO:0006283] GO:0000993; GO:0005694; GO:0006283; GO:0009411; GO:0016567 0 0 0 PF09740; O42596 CHOYP_AGAP_AGAP000974.1.1 m.31738 sp ADA22_XENLA 31.301 738 438 24 13 717 12 713 5.15E-92 323 ADA22_XENLA reviewed Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (MDC11.2) (Metalloprotease-disintegrin MDC11b) adam22 mdc11b Xenopus laevis (African clawed frog) 935 0 GO:0004222; GO:0008270; GO:0016021 0 0 0 PF08516;PF00200;PF01562;PF01421; O43586 CHOYP_PSTPIP1.1.1 m.39114 sp PPIP1_HUMAN 27.99 418 275 7 1 397 1 413 5.15E-43 158 PPIP1_HUMAN reviewed Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP) PSTPIP1 CD2BP1 Homo sapiens (Human) 416 cell adhesion [GO:0007155]; cell migration [GO:0016477]; endocytosis [GO:0006897]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; signal transduction [GO:0007165] GO:0001931; GO:0005829; GO:0005856; GO:0005886; GO:0006897; GO:0006954; GO:0007155; GO:0007165; GO:0016020; GO:0016477; GO:0030027; GO:0032154; GO:0045087; GO:0048471 0 0 0 PF00611;PF14604; P22105 CHOYP_LOC100369350.2.6 m.42373 sp TENX_HUMAN 32.889 675 301 32 103 743 201 757 5.15E-56 219 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P25067 CHOYP_MMRN1.2.2 m.52364 sp CO8A2_HUMAN 32.479 117 70 5 95 205 587 700 5.15E-09 58.5 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; Q09654 CHOYP_LOC101161952.1.1 m.60505 sp TRI23_CAEEL 31.25 112 65 4 6 109 119 226 5.15E-07 55.1 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q460N5 CHOYP_PAR14.6.17 m.34223 sp PAR14_HUMAN 33.14 172 109 4 355 522 1027 1196 5.15E-14 79.3 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q54KA7 CHOYP_AASI_1435.7.35 m.32829 sp SECG_DICDI 37.563 394 244 2 3 394 85 478 5.15E-63 221 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5BKX0 CHOYP_TM248.1.1 m.58361 sp TM248_DANRE 30.097 309 193 6 34 329 9 307 5.15E-47 164 TM248_DANRE reviewed Transmembrane protein 248 tmem248 zgc:103561 Danio rerio (Zebrafish) (Brachydanio rerio) 315 0 GO:0016021 0 0 0 0 Q5DU00 CHOYP_DCDC2.4.7 m.38230 sp DCDC2_MOUSE 29.275 345 178 14 13 339 61 357 5.15E-22 103 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q6DE06 CHOYP_BRAFLDRAFT_85791.1.1 m.42986 sp TM2D3_XENLA 53.96 202 87 2 63 259 47 247 5.15E-76 234 TM2D3_XENLA reviewed TM2 domain-containing protein 3 tm2d3 Xenopus laevis (African clawed frog) 247 0 GO:0016021 0 0 0 PF05154; Q6L5F5 CHOYP_LOC101166634.1.1 m.36726 sp IMCE_ORYSJ 32.474 194 106 6 32 205 47 235 5.15E-24 107 IMCE_ORYSJ reviewed Probable isoprenylcysteine alpha-carbonyl methylesterase ICME (EC 3.1.1.n2) IMCE Os05g0577200 LOC_Os05g50170 OJ1126_B10.7 Oryza sativa subsp. japonica (Rice) 414 metabolic process [GO:0008152] GO:0000139; GO:0005789; GO:0008152; GO:0016021; GO:0052689 0 0 0 PF07859; Q6NT55 CHOYP_LOC100013319.1.1 m.37584 sp CP4FN_HUMAN 43.542 480 247 8 32 499 57 524 5.15E-129 388 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q7T0B1 CHOYP_STK40.1.1 m.9484 sp STK40_CHICK 61.358 427 148 7 408 827 4 420 5.15E-173 509 STK40_CHICK reviewed Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine-protein kinase lyk4) STK40 Gallus gallus (Chicken) 435 0 GO:0004674; GO:0005524; GO:0005634; GO:0005737 0 0 cd13974; PF00069; Q8CFR0 CHOYP_LOC100693208.8.8 m.63097 sp C1QL2_MOUSE 44.068 59 30 1 59 117 159 214 5.15E-07 52 C1QL2_MOUSE reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10) C1ql2 C1qtnf10 Ctrp10 Mus musculus (Mouse) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0042802; GO:0051259 0 0 0 PF00386; Q8R143 CHOYP_contig_017085 m.20088 sp PTTG_MOUSE 53.333 135 60 2 4 137 42 174 5.15E-33 117 PTTG_MOUSE reviewed Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor) Pttg1ip Mus musculus (Mouse) 174 "negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]" GO:0002039; GO:0005634; GO:0005737; GO:0005886; GO:0006606; GO:0016020; GO:0016021; GO:0031398; GO:0043518; GO:0070062; GO:1902254; GO:1903364 0 0 0 0 Q9ULZ9 CHOYP_LOC100369238.1.1 m.496 sp MMP17_HUMAN 38.889 486 275 11 81 554 53 528 5.15E-112 350 MMP17_HUMAN reviewed Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP) MMP17 MT4MMP Homo sapiens (Human) 603 0 GO:0004222; GO:0005509; GO:0005578; GO:0005887; GO:0008047; GO:0008270; GO:0031225 0 0 cd04278; PF00045;PF00413;PF01471; Q9V0D5 CHOYP_LOC101069440.1.3 m.4206 sp MDH_PYRAB 37.017 362 219 6 30 387 6 362 5.15E-67 219 MDH_PYRAB reviewed Malate dehydrogenase (EC 1.1.1.37) mdh PYRAB08550 PAB1791 Pyrococcus abyssi (strain GE5 / Orsay) 362 tricarboxylic acid cycle [GO:0006099] GO:0005737; GO:0006099; GO:0030060 0 0 0 PF02615; A4IGL7 CHOYP_PXDN.4.5 m.45825 sp PXDN_XENTR 27.027 296 190 8 2 290 120 396 5.16E-18 89 PXDN_XENTR reviewed Peroxidasin (EC 1.11.1.7) pxdn pxn Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1457 hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037; GO:0042744; GO:0046872 0 0 0 PF03098;PF07679;PF13855;PF00093; O43399 CHOYP_LOC100878467.1.4 m.2864 sp TPD54_HUMAN 38.272 162 87 2 131 292 55 203 5.16E-28 110 TPD54_HUMAN reviewed Tumor protein D54 (hD54) (Tumor protein D52-like 2) TPD52L2 Homo sapiens (Human) 206 regulation of cell proliferation [GO:0042127] GO:0005737; GO:0042127; GO:0042803; GO:0044822; GO:0046982; GO:0048471 0 0 0 PF04201; O57592 CHOYP_RL7A.2.6 m.5690 sp RL7A_TAKRU 78.771 179 35 2 15 193 16 191 5.16E-99 291 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O95630 CHOYP_FA13A.1.2 m.298 sp STABP_HUMAN 53.913 115 47 2 8 121 6 115 5.16E-29 112 STABP_HUMAN reviewed STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase) STAMBP AMSH Homo sapiens (Human) 424 JAK-STAT cascade [GO:0007259]; mitotic cytokinesis [GO:0000281]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell proliferation [GO:0008284]; protein deubiquitination [GO:0016579] GO:0000281; GO:0004843; GO:0005634; GO:0005654; GO:0005737; GO:0005769; GO:0005886; GO:0007259; GO:0008237; GO:0008284; GO:0014067; GO:0016579; GO:0019904; GO:0032154; GO:0043524; GO:0046580; GO:0046872; GO:0070062 0 0 0 PF01398;PF08969; Q0ZAQ8 CHOYP_PPARG.1.1 m.37874 sp PPARD_CANLF 34.037 379 205 11 146 491 70 436 5.16E-57 198 PPARD_CANLF reviewed Peroxisome proliferator-activated receptor delta (PPAR-delta) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) PPARD NR1C2 PPARB Canis lupus familiaris (Dog) (Canis familiaris) 441 "adipose tissue development [GO:0060612]; apoptotic signaling pathway [GO:0097190]; axon ensheathment [GO:0008366]; cell differentiation [GO:0030154]; cell-substrate adhesion [GO:0031589]; cellular response to hypoxia [GO:0071456]; embryo implantation [GO:0007566]; fatty acid beta-oxidation [GO:0006635]; fatty acid transport [GO:0015908]; keratinocyte migration [GO:0051546]; keratinocyte proliferation [GO:0043616]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894]; placenta development [GO:0001890]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of skeletal muscle tissue regeneration [GO:0043415]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; transcription, DNA-templated [GO:0006351]; wound healing [GO:0042060]" GO:0000790; GO:0001227; GO:0001890; GO:0003707; GO:0004879; GO:0006351; GO:0006635; GO:0007566; GO:0008144; GO:0008270; GO:0008289; GO:0008366; GO:0014068; GO:0014842; GO:0015908; GO:0030154; GO:0031589; GO:0042060; GO:0043415; GO:0043565; GO:0043616; GO:0045598; GO:0045662; GO:0045893; GO:0050680; GO:0051546; GO:0060612; GO:0070539; GO:0071456; GO:0097190; GO:1902894; GO:2000288 0 0 0 PF00104;PF00105; Q3TNH5 CHOYP_F172A.2.2 m.58797 sp F172A_MOUSE 43.817 372 142 6 22 342 49 404 5.16E-88 275 F172A_MOUSE reviewed Protein FAM172A Fam172a Mus musculus (Mouse) 417 0 GO:0005576; GO:0005783 0 0 0 PF09757; Q3ZC15 CHOYP_RCAN2.1.1 m.25848 sp RCAN2_BOVIN 48.305 118 60 1 2 118 25 142 5.16E-32 114 RCAN2_BOVIN reviewed Calcipressin-2 (Down syndrome candidate region 1-like 1) (Regulator of calcineurin 2) RCAN2 DSCR1L1 Bos taurus (Bovine) 197 calcium-mediated signaling [GO:0019722]; regulation of calcineurin-NFAT signaling cascade [GO:0070884] GO:0000166; GO:0005737; GO:0008597; GO:0019722; GO:0070884 0 0 0 PF04847; Q5BIM1 CHOYP_LOC100370907.2.3 m.15763 sp TRI45_BOVIN 24.699 166 111 5 4 156 127 291 5.16E-07 52.4 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5FWN7 CHOYP_AKIRIN2.1.1 m.11193 sp C108A_XENLA 45.96 198 86 5 1 189 1 186 5.16E-48 157 C108A_XENLA reviewed Uncharacterized protein C1orf108 homolog A 0 Xenopus laevis (African clawed frog) 186 0 0 0 0 0 0 Q5R7B4 CHOYP_LOC100765804.1.1 m.61102 sp STRA6_PONAB 24.896 241 159 2 392 620 421 651 5.16E-14 79 STRA6_PONAB reviewed Stimulated by retinoic acid gene 6 protein homolog STRA6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 667 0 GO:0004872; GO:0005886; GO:0016021; GO:0051183 0 0 0 0 Q5U1Y1 CHOYP_LOC100179448.1.1 m.8295 sp RAB34_RAT 52.941 255 113 4 12 262 7 258 5.16E-94 280 RAB34_RAT reviewed Ras-related protein Rab-34 Rab34 Rattus norvegicus (Rat) 259 phagosome-lysosome fusion [GO:0090385]; phagosome maturation [GO:0090382]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0030670; GO:0045335; GO:0090382; GO:0090385 0 0 0 PF00071; Q60HD2 CHOYP_ATL1.1.1 m.21417 sp ATLA1_MACFA 37.534 365 224 3 1 363 72 434 5.16E-78 261 ATLA1_MACFA reviewed Atlastin-1 (EC 3.6.5.-) ATL1 QflA-10403 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; protein homooligomerization [GO:0051260] GO:0000137; GO:0000139; GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0005794; GO:0007029; GO:0007409; GO:0016021; GO:0030424; GO:0042802; GO:0051260 0 0 0 PF02263; Q67VW6 CHOYP_GPATCH1.1.1 m.20158 sp TGHH_ORYSJ 43.299 97 43 3 37 122 1 96 5.16E-17 79 TGHH_ORYSJ reviewed G patch domain-containing protein TGH homolog (Protein TOUGH homolog) Os06g0489200 LOC_Os06g29400 OsJ_21406 P0583E12.23 Oryza sativa subsp. japonica (Rice) 984 gene silencing by RNA [GO:0031047]; mRNA processing [GO:0006397]; regulation of growth [GO:0040008] GO:0003723; GO:0005634; GO:0006397; GO:0031047; GO:0040008 0 0 0 PF07713;PF01805; Q7RVM2 CHOYP_SMP_088650.2.3 m.15853 sp ARF_NEUCR 54.11 146 67 0 1 146 8 153 5.16E-51 166 ARF_NEUCR reviewed ADP-ribosylation factor NCU08340 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 185 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q9LQV2 CHOYP_BRAFLDRAFT_99723.8.9 m.61481 sp RDR1_ARATH 34.172 1033 605 26 195 1182 91 1093 5.16E-144 468 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; Q9NRG9 CHOYP_LOC100366577.2.2 m.40625 sp AAAS_HUMAN 47.273 165 86 1 3 167 272 435 5.16E-45 158 AAAS_HUMAN reviewed Aladin (Adracalin) AAAS ADRACALA GL003 Homo sapiens (Human) 546 fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; intracellular transport of virus [GO:0075733]; learning [GO:0007612]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; nucleocytoplasmic transport [GO:0006913]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; regulation of nucleocytoplasmic transport [GO:0046822]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]; viral transcription [GO:0019083] GO:0005634; GO:0005635; GO:0005643; GO:0005654; GO:0005737; GO:0005813; GO:0006406; GO:0006409; GO:0006913; GO:0007077; GO:0007612; GO:0009566; GO:0010827; GO:0015031; GO:0016020; GO:0016032; GO:0016925; GO:0019083; GO:0031047; GO:0031965; GO:0046822; GO:0075733; GO:1900034 0 0 0 PF00400; A2ASQ1 CHOYP_CMU_009430.1.2 m.29741 sp AGRIN_MOUSE 25.714 105 67 2 72 175 323 417 5.17E-06 50.1 AGRIN_MOUSE reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] Agrn Agrin Mus musculus (Mouse) 1950 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; glycosaminoglycan biosynthetic process [GO:0006024]; multicellular organism development [GO:0007275]; negative regulation of sodium:potassium-exchanging ATPase activity [GO:1903407]; negative regulation of sodium ion export from cell [GO:1903277]; neuromuscular junction development [GO:0007528]; neurotransmitter receptor metabolic process [GO:0045213]; plasma membrane organization [GO:0007009]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein binding [GO:0032092]; positive regulation of protein geranylgeranylation [GO:2000541]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; receptor clustering [GO:0043113]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of GTPase activity [GO:0043087]; regulation of synaptic growth at neuromuscular junction [GO:0008582] GO:0001934; GO:0002162; GO:0005509; GO:0005576; GO:0005604; GO:0005605; GO:0005615; GO:0005737; GO:0005796; GO:0005886; GO:0006024; GO:0007009; GO:0007268; GO:0007275; GO:0007528; GO:0008582; GO:0009986; GO:0016021; GO:0030054; GO:0030154; GO:0030548; GO:0031012; GO:0032092; GO:0033691; GO:0035374; GO:0042030; GO:0043087; GO:0043113; GO:0043395; GO:0043525; GO:0043547; GO:0044325; GO:0045202; GO:0045213; GO:0045887; GO:0045944; GO:0051491; GO:0055117; GO:0061098; GO:0070062; GO:0086036; GO:1903277; GO:1903407; GO:2000541 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF01390; B2RU80 CHOYP_PTPRB.3.4 m.52977 sp PTPRB_MOUSE 31.54 818 460 29 701 1475 1232 1992 5.17E-88 321 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; E1BD59 CHOYP_TRI56.4.4 m.61739 sp TRI56_BOVIN 23.304 339 217 9 38 355 21 337 5.17E-16 85.5 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O35309 CHOYP_LOC100367414.7.7 m.61626 sp NMI_MOUSE 33.803 142 81 5 13 143 160 299 5.17E-09 58.9 NMI_MOUSE reviewed N-myc-interactor (Nmi) (N-myc and STAT interactor) Nmi Mus musculus (Mouse) 314 interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha biosynthetic process [GO:0045355]; negative regulation of interferon-beta biosynthetic process [GO:0045358]; negative regulation of type I interferon production [GO:0032480]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003712; GO:0005654; GO:0005737; GO:0006366; GO:0032480; GO:0045355; GO:0045358; GO:0045824; GO:0060333; GO:1902524 0 0 0 PF07334;PF07292; O43301 CHOYP_BRAFLDRAFT_208436.4.32 m.22687 sp HS12A_HUMAN 33.49 639 335 16 12 577 54 675 5.17E-112 352 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O73791 CHOYP_LOC101062986.1.3 m.22076 sp TIE2_DANRE 34.483 145 59 9 41 165 218 346 5.17E-14 73.6 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O75962 CHOYP_PHUM_PHUM149600.1.1 m.26170 sp TRIO_HUMAN 46.316 95 48 2 118 209 746 840 5.17E-16 79.3 TRIO_HUMAN reviewed Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein) TRIO Homo sapiens (Human) 3097 positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0004674; GO:0005085; GO:0005089; GO:0005524; GO:0005829; GO:0007185; GO:0035023; GO:0043065; GO:0051056 0 0 0 PF00650;PF07679;PF00169;PF00069;PF00621;PF00018;PF00435; P18489 CHOYP_LOC100699603.2.2 m.44436 sp SYB_DROME 32.558 86 58 0 45 130 41 126 5.17E-10 58.2 SYB_DROME reviewed Synaptobrevin Syb CG12210 Drosophila melanogaster (Fruit fly) 152 "exocytosis [GO:0006887]; lumen formation, open tracheal system [GO:0035149]; neurotransmitter secretion [GO:0007269]; synaptic vesicle docking [GO:0016081]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" GO:0000149; GO:0005484; GO:0005886; GO:0006887; GO:0006906; GO:0007269; GO:0008021; GO:0016021; GO:0016081; GO:0016192; GO:0030054; GO:0030672; GO:0035149; GO:0043005 0 0 0 PF00957; P21329 CHOYP_LOC100890922.1.1 m.33255 sp RTJK_DROFU 21.457 247 172 8 65 301 258 492 5.17E-06 51.6 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; P30974 CHOYP_LOC100539861.1.1 m.23398 sp TLR1_DROME 21.387 346 206 9 21 354 88 379 5.17E-08 58.2 TLR1_DROME reviewed Tachykinin-like peptides receptor 86C (NKD) TkR86C NKD Takr86C CG6515 Drosophila melanogaster (Fruit fly) 504 G-protein coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217] GO:0002121; GO:0004995; GO:0005887; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016021 0 0 0 PF00001; P36241 CHOYP_POL4.3.4 m.44717 sp RL19_DROME 71.667 120 34 0 1 120 76 195 5.17E-48 155 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; Q3SZI0 CHOYP_MPI.1.1 m.35645 sp MPI_BOVIN 47.837 416 214 3 7 421 6 419 5.17E-141 412 MPI_BOVIN reviewed Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphohexomutase) (Phosphomannose isomerase) (PMI) MPI Bos taurus (Bovine) 423 carbohydrate metabolic process [GO:0005975]; GDP-mannose biosynthetic process [GO:0009298] GO:0004476; GO:0005737; GO:0005975; GO:0008270; GO:0009298 PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2. 0 0 PF01238; Q4R6F0 CHOYP_LOC100187348.1.1 m.29904 sp LRRD1_MACFA 28.299 629 409 8 90 709 149 744 5.17E-54 204 LRRD1_MACFA reviewed Leucine-rich repeat and death domain-containing protein 1 LRRD1 QtsA-18164 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 863 signal transduction [GO:0007165] GO:0007165 0 0 0 PF13855; Q6GNK9 CHOYP_NDNF.1.1 m.56568 sp NDNF_XENLA 26.232 568 357 14 10 520 7 569 5.17E-58 205 NDNF_XENLA reviewed Protein NDNF ndnf Xenopus laevis (African clawed frog) 569 cell growth [GO:0016049]; extracellular matrix organization [GO:0030198]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan [GO:0019800]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron projection development [GO:0010976] GO:0001764; GO:0005539; GO:0005576; GO:0008201; GO:0010811; GO:0010976; GO:0016049; GO:0019800; GO:0030198; GO:0031012; GO:0043524 0 0 0 PF10179; Q6PST4 CHOYP_ATLA1.4.4 m.59471 sp ATLA1_RAT 38.647 414 243 4 16 427 30 434 5.17E-93 301 ATLA1_RAT reviewed Atlastin-1 (EC 3.6.5.-) (Spastic paraplegia 3A homolog) Atl1 Spg3a Rattus norvegicus (Rat) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; protein homooligomerization [GO:0051260] GO:0000137; GO:0000139; GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0005794; GO:0007029; GO:0007409; GO:0016021; GO:0030424; GO:0042802; GO:0051260 0 0 0 PF02263; Q8BGN2 CHOYP_LOC101422627.1.1 m.40502 sp CD033_MOUSE 55.801 181 76 2 31 207 4 184 5.17E-68 209 CD033_MOUSE reviewed UPF0462 protein C4orf33 homolog D3Ertd751e Mus musculus (Mouse) 192 0 0 0 0 0 0 Q96A58 CHOYP_RERG.1.2 m.4035 sp RERG_HUMAN 48.691 191 95 2 35 225 8 195 5.17E-57 182 RERG_HUMAN reviewed Ras-related and estrogen-regulated growth inhibitor RERG Homo sapiens (Human) 199 negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0005829; GO:0007264; GO:0008285; GO:0009725; GO:0016020; GO:0019003; GO:0030308; GO:0030331 0 0 0 PF00071; Q96MM6 CHOYP_BRAFLDRAFT_208436.6.32 m.31980 sp HS12B_HUMAN 31.269 646 350 15 9 579 60 686 5.17E-100 321 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9ESN6 CHOYP_LOC100369333.11.32 m.32523 sp TRIM2_MOUSE 24.883 213 133 7 340 540 534 731 5.17E-08 59.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9I8C7 CHOYP_CHRNA9.2.3 m.34258 sp ACH10_CHICK 35.493 355 213 6 1 342 1 352 5.17E-77 248 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; A6NMZ7 CHOYP_LOC100708991.1.5 m.740 sp CO6A6_HUMAN 30.318 409 249 12 17 420 610 987 5.18E-43 165 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; B2RPV6 CHOYP_ZGC_136272.1.1 m.5887 sp MMRN1_MOUSE 34.286 140 81 5 865 1001 1076 1207 5.18E-09 64.3 MMRN1_MOUSE reviewed Multimerin-1 Mmrn1 Mus musculus (Mouse) 1210 blood coagulation [GO:0007596] GO:0005509; GO:0005576; GO:0007596 0 0 0 PF00386;PF00008;PF07546; P18172 CHOYP_LOC100651467.2.2 m.55704 sp DHGL_DROPS 39.405 571 301 14 38 593 65 605 5.18E-116 362 DHGL_DROPS reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) 625 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; P27393 CHOYP_CO4A1.1.2 m.36472 sp CO4A2_ASCSU 48.79 248 94 7 137 361 1064 1301 5.18E-30 128 CO4A2_ASCSU reviewed Collagen alpha-2(IV) chain 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 1763 0 GO:0005201; GO:0005581; GO:0005604 0 0 0 PF01413;PF01391; P74148 CHOYP_NEMVEDRAFT_V1G236658.3.6 m.24704 sp Y1388_SYNY3 33.981 103 66 1 52 154 54 154 5.18E-15 70.9 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P82596 CHOYP_ASGR2.3.4 m.47793 sp PLC_HALLA 38.346 133 76 5 22 152 2 130 5.18E-22 89.4 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q08CX2 CHOYP_LOC576200.1.4 m.14081 sp SH24A_XENTR 46.491 114 57 2 1 110 1 114 5.18E-25 100 SH24A_XENTR reviewed SH2 domain-containing protein 4A sh2d4a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 453 negative regulation of phosphatase activity [GO:0010923] GO:0005737; GO:0010923; GO:0019902 0 0 0 PF00017; Q0PV50 CHOYP_TLR3.4.6 m.45599 sp TLR3_BOSTR 23.649 296 186 12 231 490 433 724 5.18E-08 59.3 TLR3_BOSTR reviewed Toll-like receptor 3 (CD antigen CD283) TLR3 Boselaphus tragocamelus (Nilgai) 904 defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138] GO:0002756; GO:0003725; GO:0004888; GO:0005769; GO:0005789; GO:0006954; GO:0010008; GO:0016021; GO:0032722; GO:0034138; GO:0043330; GO:0045087; GO:0050729; GO:0051607 0 0 0 PF13516;PF13855;PF01582; Q0VGY8 CHOYP_LOC755512.4.5 m.33019 sp TANC1_MOUSE 42.241 116 67 0 3 118 1099 1214 5.18E-21 90.9 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q2WEA5 CHOYP_BRAFLDRAFT_70987.1.2 m.54595 sp TRPM1_RAT 27.842 607 389 14 17 596 660 1244 5.18E-68 243 TRPM1_RAT reviewed Transient receptor potential cation channel subfamily M member 1 (Melastatin-1) Trpm1 Rattus norvegicus (Rat) 1628 calcium ion transport into cytosol [GO:0060402]; cellular response to light stimulus [GO:0071482]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; protein tetramerization [GO:0051262] GO:0005262; GO:0005886; GO:0007216; GO:0016021; GO:0051262; GO:0060402; GO:0071482 0 0 0 PF00520;PF16519; Q54CX4 CHOYP_BRAFLDRAFT_255756.1.1 m.58817 sp Y5521_DICDI 25.521 192 125 6 101 286 632 811 5.18E-10 63.5 Y5521_DICDI reviewed Uncharacterized protein DDB_G0292642 DDB_G0292642 Dictyostelium discoideum (Slime mold) 903 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005737; GO:0008270; GO:0016021; GO:0031624; GO:0032436; GO:0042787; GO:0061630 0 0 0 PF01485;PF13639; Q5FVR2 CHOYP_BRAFLDRAFT_244533.2.2 m.53951 sp TYPH_RAT 48 425 219 2 7 430 29 452 5.18E-135 399 TYPH_RAT reviewed Thymidine phosphorylase (TP) (EC 2.4.2.4) (TdRPase) Tymp Ecgf1 Rattus norvegicus (Rat) 476 pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]; pyrimidine nucleotide metabolic process [GO:0006220] GO:0004645; GO:0005829; GO:0006206; GO:0006213; GO:0006220; GO:0009032; GO:0016154 PATHWAY: Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. 0 0 PF02885;PF00591;PF07831; Q5I7G2 CHOYP_RBM22.1.1 m.43646 sp RXR_LYMST 65.823 158 41 3 41 190 29 181 5.18E-65 209 RXR_LYMST reviewed Retinoic acid receptor RXR (Retinoid X receptor) (LymRXR) RXR Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 436 "multicellular organism development [GO:0007275]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0005737; GO:0006351; GO:0007275; GO:0008270; GO:0016020; GO:0016918; GO:0030424; GO:0030426; GO:0043565 0 0 0 PF00104;PF00105; Q60821 CHOYP_ZNF91.3.4 m.11564 sp ZBT17_MOUSE 25.352 497 281 16 478 909 287 758 5.18E-28 125 ZBT17_MOUSE reviewed Zinc finger and BTB domain-containing protein 17 (LP-1) (Polyomavirus late initiator promoter-binding protein) (Zinc finger protein 100) (Zfp-100) (Zinc finger protein 151) (Zinc finger protein Z13) Zbtb17 Zfp100 Znf151 Mus musculus (Mouse) 794 "ectoderm development [GO:0007398]; gastrulation with mouth forming second [GO:0001702]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of mitophagy [GO:1903146]; transcription, DNA-templated [GO:0006351]" GO:0001702; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007398; GO:0045893; GO:0046872; GO:1903146; GO:1903955 0 0 0 PF00651;PF00096; Q6MFY5 CHOYP_ZNRD1.1.2 m.7107 sp RPA12_RAT 52.893 121 56 1 1 120 3 123 5.18E-44 142 RPA12_RAT reviewed DNA-directed RNA polymerase I subunit RPA12 (Zinc ribbon domain-containing protein 1) Znrd1 Rattus norvegicus (Rat) 123 termination of RNA polymerase I transcription [GO:0006363] GO:0003676; GO:0003899; GO:0005736; GO:0006363; GO:0008270 0 0 0 PF01096; Q6P0U0 CHOYP_AMDHD2.2.2 m.52160 sp NAGA_DANRE 59.259 405 162 3 185 587 1 404 5.18E-171 494 NAGA_DANRE reviewed N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) (EC 3.5.1.25) (Amidohydrolase domain-containing protein 2) amdhd2 zgc:77775 Danio rerio (Zebrafish) (Brachydanio rerio) 404 carbohydrate metabolic process [GO:0005975]; N-acetylglucosamine catabolic process [GO:0006046]; N-acetylneuraminate catabolic process [GO:0019262] GO:0005634; GO:0005975; GO:0006046; GO:0008448; GO:0019262; GO:0046872 PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000250|UniProtKB:Q9Y303}. 0 cd00854; PF01979; Q6P632 CHOYP_BRAFLDRAFT_284784.1.1 m.12397 sp NAA20_XENTR 73.034 178 43 2 13 185 1 178 5.18E-96 279 NAA20_XENTR reviewed N-alpha-acetyltransferase 20 (EC 2.3.1.88) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit) naa20 nat5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 178 N-terminal peptidyl-methionine acetylation [GO:0017196] GO:0004596; GO:0005634; GO:0017196; GO:0031416 0 0 0 PF00583; Q7RTY1 CHOYP_ISCW_ISCW023788.1.1 m.32082 sp MOT9_HUMAN 30 530 315 12 25 547 7 487 5.18E-60 210 MOT9_HUMAN reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 C10orf36 MCT9 Homo sapiens (Human) 509 urate metabolic process [GO:0046415] GO:0005886; GO:0008028; GO:0015293; GO:0016021; GO:0046415 0 0 cd06174; PF07690; Q8K039 CHOYP_KIAA1143.1.1 m.1249 sp K1143_MOUSE 42.308 156 73 5 5 150 6 154 5.18E-31 112 K1143_MOUSE reviewed Uncharacterized protein KIAA1143 homolog 0 Mus musculus (Mouse) 155 0 0 0 0 0 PF15377; Q9DCT6 CHOYP_BAP18.1.1 m.48944 sp BAP18_MOUSE 52.326 172 68 6 1 161 1 169 5.18E-47 154 BAP18_MOUSE reviewed Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa) Bap18 Mus musculus (Mouse) 171 covalent chromatin modification [GO:0016569] GO:0003677; GO:0005654; GO:0005737; GO:0016569; GO:0016589; GO:0071339 0 0 0 0 Q9ES30 CHOYP_C1QT3.4.8 m.22821 sp C1QT3_MOUSE 34.646 127 71 5 131 249 118 240 5.18E-07 52.8 C1QT3_MOUSE reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) 246 cellular triglyceride homeostasis [GO:0035356]; glucose homeostasis [GO:0042593]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein kinase B signaling [GO:0051897]; protein oligomerization [GO:0051259]; protein trimerization [GO:0070206] GO:0005576; GO:0005581; GO:0005615; GO:0005623; GO:0016020; GO:0035356; GO:0042347; GO:0042593; GO:0042802; GO:0045721; GO:0050715; GO:0050728; GO:0051259; GO:0051897; GO:0070062; GO:0070165; GO:0070206; GO:0070374; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9QXW9 CHOYP_CPIPJ_CPIJ015772.1.1 m.36200 sp LAT2_MOUSE 34.909 275 176 1 3 277 217 488 5.18E-52 181 LAT2_MOUSE reviewed Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (mLAT2) (Solute carrier family 7 member 8) Slc7a8 Lat2 Mus musculus (Mouse) 531 amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; neutral amino acid transport [GO:0015804] GO:0005275; GO:0005737; GO:0005886; GO:0005887; GO:0006865; GO:0015101; GO:0015171; GO:0015175; GO:0015179; GO:0015297; GO:0015804; GO:0015807; GO:0016323; GO:0019534; GO:0070062 0 0 0 PF13520; A2BDA5 CHOYP_DCA15.1.1 m.11376 sp DCA15_XENLA 37.815 238 123 4 5 232 36 258 5.19E-41 162 DCA15_XENLA reviewed DDB1- and CUL4-associated factor 15 dcaf15 Xenopus laevis (African clawed frog) 600 protein ubiquitination [GO:0016567] GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF14939; A4IF63 CHOYP_BRAFLDRAFT_255103.14.18 m.55178 sp TRIM2_BOVIN 32.759 116 73 3 324 434 629 744 5.19E-08 58.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6QPC8 CHOYP_CBG12070.1.1 m.62281 sp EID3_BOVIN 29.05 179 117 2 973 1144 96 271 5.19E-13 76.3 EID3_BOVIN reviewed EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) EID3 Bos taurus (Bovine) 379 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005737; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0030915 0 0 0 PF15412;PF08743; B9F655 CHOYP_LOC100888319.1.1 m.10247 sp PIRL7_ORYSJ 36.667 150 88 2 66 215 54 196 5.19E-16 82 PIRL7_ORYSJ reviewed Plant intracellular Ras-group-related LRR protein 7 (Intracellular Ras-group-related LRR protein 7) (OsIRL7) IRL7 Os03g0212200 LOC_Os03g11360 OsJ_09890 Oryza sativa subsp. japonica (Rice) 262 0 0 0 0 0 PF13855; H1AFJ7 CHOYP_LOC100891438.2.3 m.30346 sp SCNNG_NEOFS 27.35 351 218 10 66 397 240 572 5.19E-41 157 SCNNG_NEOFS reviewed Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) scnn1g enacgamma Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri) 653 response to stimulus [GO:0050896]; sensory perception of taste [GO:0050909]; sodium ion transmembrane transport [GO:0035725] GO:0015280; GO:0016324; GO:0034706; GO:0035725; GO:0050896; GO:0050909 0 0 0 PF00858; P0C6X5 CHOYP_K655_GP1.1.1 m.52481 sp R1AB_CVHNL 23.052 1566 986 61 332 1822 4526 5947 5.19E-44 181 R1AB_CVHNL reviewed Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (p9); Non-structural protein 2 (nsp2) (p87); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.-) (PL1-PRO/PL2-PRO) (PLP1/PLP2) (Papain-like proteinases 1/2) (p195); Non-structural protein 4 (nsp4) (Peptide HD2); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p34); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7) (p5); Non-structural protein 8 (nsp8) (p23); Non-structural protein 9 (nsp9) (p12); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p14); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (nsp12) (p100); Helicase (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (nsp13) (p66) (p66-HEL); Exoribonuclease (ExoN) (EC 3.1.13.-) (nsp14); Uridylate-specific endoribonuclease (EC 3.1.-.-) (NendoU) (nsp15) (p41); Putative 2'-O-methyl transferase (EC 2.1.1.-) (nsp16)] rep 1a-1b Human coronavirus NL63 (HCoV-NL63) 6729 "induction by virus of host autophagy [GO:0039520]; modulation by virus of host protein ubiquitination [GO:0039648]; suppression by virus of host IRF3 activity [GO:0039548]; transcription, DNA-templated [GO:0006351]; viral protein processing [GO:0019082]; viral RNA genome replication [GO:0039694]" GO:0003723; GO:0003968; GO:0004197; GO:0004386; GO:0004519; GO:0005524; GO:0006351; GO:0008168; GO:0008242; GO:0008270; GO:0016021; GO:0016896; GO:0019082; GO:0033644; GO:0036459; GO:0039520; GO:0039548; GO:0039648; GO:0039694; GO:0044172; GO:0044220 0 0 0 PF16348;PF06478;PF01661;PF09401;PF06471;PF06460;PF08716;PF08717;PF08710;PF05409;PF08715; P20825 CHOYP_contig_007396 m.8539 sp POL2_DROME 43.523 386 204 5 1 379 244 622 5.19E-96 326 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P49165 CHOYP_LOC100208996.1.1 m.22802 sp RL4_URECA 64.653 331 114 3 1 329 1 330 5.19E-161 458 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; P50430 CHOYP_BRAFLDRAFT_206907.5.11 m.19272 sp ARSB_RAT 43.478 414 197 7 90 467 36 448 5.19E-119 362 ARSB_RAT reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb Rattus norvegicus (Rat) 528 autophagy [GO:0006914]; central nervous system development [GO:0007417]; colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005791; GO:0005794; GO:0006914; GO:0007417; GO:0007584; GO:0008152; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0043627; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; P69478 CHOYP_CHSTB.1.1 m.54672 sp CHSTB_RAT 37.857 280 160 6 85 356 77 350 5.19E-68 221 CHSTB_RAT reviewed Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4S-1) (C4ST-1) (C4ST1) Chst11 Rattus norvegicus (Rat) 352 carbohydrate biosynthetic process [GO:0016051]; chondrocyte development [GO:0002063]; chondroitin sulfate biosynthetic process [GO:0030206]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; embryonic viscerocranium morphogenesis [GO:0048703]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; polysaccharide localization [GO:0033037]; post-anal tail morphogenesis [GO:0036342]; post-embryonic development [GO:0009791]; regulation of cell proliferation [GO:0042127]; respiratory gaseous exchange [GO:0007585] GO:0000139; GO:0001537; GO:0002063; GO:0007585; GO:0009791; GO:0016021; GO:0016051; GO:0030206; GO:0030512; GO:0033037; GO:0036342; GO:0042127; GO:0042733; GO:0043066; GO:0047756; GO:0048589; GO:0048703; GO:0050659 0 0 0 PF03567; Q09738 CHOYP_LOC101307995.1.1 m.57720 sp UBP8_SCHPO 23.975 317 212 9 597 910 146 436 5.19E-19 94.4 UBP8_SCHPO reviewed Probable ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) ubp8 SPAC13A11.04c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 449 histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; protein deubiquitination [GO:0016579]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000124; GO:0004843; GO:0005634; GO:0005654; GO:0006357; GO:0006511; GO:0008270; GO:0016579; GO:0035616 0 0 0 PF00443;PF02148; Q15404 CHOYP_RSU1.1.1 m.44138 sp RSU1_HUMAN 68.846 260 79 2 1 259 1 259 5.19E-129 370 RSU1_HUMAN reviewed Ras suppressor protein 1 (RSP-1) (Rsu-1) RSU1 RSP1 Homo sapiens (Human) 277 positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] GO:0005829; GO:0005925; GO:0007165; GO:0010811; GO:0043547; GO:0070062 0 0 0 PF13855; Q49LS8 CHOYP_LOC101169752.1.1 m.33941 sp XKR6_TETNG 27.049 366 237 6 148 500 87 435 5.19E-32 132 XKR6_TETNG reviewed XK-related protein 6 xkr6 xrg6 GSTENG00030285001 GSTENG00030286001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 578 0 GO:0016021 0 0 0 PF09815; Q6XBJ3 CHOYP_PHUM_PHUM228480.1.1 m.498 sp ONEC2_MOUSE 29.87 154 100 4 132 281 334 483 5.19E-08 59.7 ONEC2_MOUSE reviewed One cut domain family member 2 (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2) Onecut2 Oc2 Mus musculus (Mouse) 505 anatomical structure morphogenesis [GO:0009653]; cell fate commitment [GO:0045165]; cilium assembly [GO:0042384]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; pancreas development [GO:0031016]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell migration [GO:0030335]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952] GO:0000978; GO:0001077; GO:0001889; GO:0001952; GO:0002064; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0009653; GO:0015629; GO:0030335; GO:0030512; GO:0031016; GO:0031018; GO:0042384; GO:0045165; GO:0045944; GO:0048935 0 0 0 PF02376;PF00046; Q7KW14 CHOYP_LOC100883165.1.2 m.499 sp CCDCX_DROME 44.608 204 89 3 504 701 573 758 5.19E-38 159 CCDCX_DROME reviewed Coiled-coil domain-containing protein CG32809 CG32809 Drosophila melanogaster (Fruit fly) 1234 0 0 0 0 0 PF03915; Q8C0X8 CHOYP_SMKX.1.1 m.48584 sp SMKX_MOUSE 30.175 285 174 8 101 385 13 272 5.19E-28 119 SMKX_MOUSE reviewed Sperm motility kinase X (EC 2.7.11.1) 0 Mus musculus (Mouse) 640 cellular response to hormone stimulus [GO:0032870]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0032870; GO:0035556 0 0 0 PF00069; Q90YS3 CHOYP_LOC100363271.1.1 m.21156 sp RS2_ICTPU 86.695 233 31 0 14 246 32 264 5.19E-149 419 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q90YV7 CHOYP_RL11.3.7 m.25578 sp RL11_ICTPU 86.301 146 20 0 15 160 6 151 5.19E-91 265 RL11_ICTPU reviewed 60S ribosomal protein L11 rpl11 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 178 protein localization to nucleus [GO:0034504]; translation [GO:0006412] GO:0003735; GO:0005730; GO:0005840; GO:0006412; GO:0019843; GO:0034504 0 0 0 PF00281;PF00673; Q91YE6 CHOYP_IPO9.4.4 m.66872 sp IPO9_MOUSE 58.333 120 50 0 2 121 317 436 5.19E-46 164 IPO9_MOUSE reviewed Importin-9 (Imp9) (Importin-9a) (Imp9a) (Importin-9b) (Imp9b) (Ran-binding protein 9) (RanBP9) Ipo9 Imp9 Ranbp9 Mus musculus (Mouse) 1041 protein import into nucleus [GO:0006606]; protein stabilization [GO:0050821]; ribosomal protein import into nucleus [GO:0006610]; ribosome biogenesis [GO:0042254]; transcription factor import into nucleus [GO:0042991] GO:0005635; GO:0005737; GO:0005829; GO:0006606; GO:0006610; GO:0008536; GO:0008565; GO:0016020; GO:0042254; GO:0042393; GO:0042991; GO:0050821 0 0 0 PF03810; Q9BXM0 CHOYP_LOC100933241.2.45 m.13563 sp PRAX_HUMAN 25.588 340 205 9 1 314 441 758 5.19E-10 64.3 PRAX_HUMAN reviewed Periaxin PRX KIAA1620 Homo sapiens (Human) 1461 axon ensheathment [GO:0008366]; nerve development [GO:0021675] GO:0005634; GO:0005737; GO:0005886; GO:0008366; GO:0021675; GO:0030054; GO:0043209 0 0 0 0 Q9W6B3 CHOYP_NR1H4.2.2 m.54740 sp RARB_COTJA 25.765 392 237 9 63 450 47 388 5.19E-36 142 RARB_COTJA reviewed Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2) RARB NR1B2 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 455 "transcription, DNA-templated [GO:0006351]" GO:0003707; GO:0003708; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; Q9Y345 CHOYP_SLC6A14.1.1 m.43828 sp SC6A5_HUMAN 41.941 608 332 7 21 626 172 760 5.19E-164 493 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; D9IQ16 CHOYP_LOC100180758.1.2 m.25809 sp GXN_ACRMI 28.378 296 158 11 43 329 60 310 5.20E-17 86.3 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 O60462 CHOYP_NRP2.3.8 m.22980 sp NRP2_HUMAN 29.008 262 149 13 50 295 25 265 5.20E-17 89 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O61967 CHOYP_LRC40.2.2 m.35584 sp LAP1_CAEEL 37.931 145 89 1 148 292 38 181 5.20E-17 85.1 LAP1_CAEEL reviewed Protein lap1 (Lethal protein 413) let-413 F26D11.11 Caenorhabditis elegans 699 actin filament-based process [GO:0030029]; cell adhesion [GO:0007155]; cell-cell junction assembly [GO:0007043]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract morphogenesis [GO:0048557]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; protein transport [GO:0015031]; regulation of intermediate filament polymerization or depolymerization [GO:0045108] GO:0005912; GO:0007043; GO:0007155; GO:0007163; GO:0009792; GO:0015031; GO:0016323; GO:0030029; GO:0045108; GO:0045199; GO:0048557 0 0 0 PF13855;PF00595; P15308 CHOYP_BRAFLDRAFT_190162.5.5 m.50115 sp B4_XENLA 42.466 73 35 1 38 110 41 106 5.20E-10 61.2 B4_XENLA reviewed Protein B4 (Histone H1-like protein) (Linker histone B4) b4 Xenopus laevis (African clawed frog) 273 multicellular organism development [GO:0007275]; nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0007275 0 0 0 PF00538; P17078 CHOYP_LOC100922776.1.2 m.34613 sp RL35_RAT 72.358 123 33 1 1 123 1 122 5.20E-53 165 RL35_RAT reviewed 60S ribosomal protein L35 Rpl35 Rattus norvegicus (Rat) 123 "cellular response to UV-B [GO:0071493]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; translation [GO:0006412]" GO:0000463; GO:0003729; GO:0003735; GO:0006412; GO:0022625; GO:0043021; GO:0071493 0 0 cd00427; PF00831; P30622 CHOYP_LOC100369031.1.1 m.19197 sp CLIP1_HUMAN 31.611 987 513 26 51 934 55 982 5.20E-104 363 CLIP1_HUMAN reviewed CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) CLIP1 CYLN1 RSN Homo sapiens (Human) 1438 microtubule bundle formation [GO:0001578]; mitotic nuclear division [GO:0007067]; positive regulation of microtubule polymerization [GO:0031116]; protein transport into plasma membrane raft [GO:0044861]; sister chromatid cohesion [GO:0007062] GO:0000776; GO:0001578; GO:0001726; GO:0005737; GO:0005768; GO:0005813; GO:0005829; GO:0005874; GO:0005881; GO:0005882; GO:0007062; GO:0007067; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0030659; GO:0031116; GO:0035371; GO:0042803; GO:0044861; GO:0046872; GO:0051010; GO:1990752 0 0 0 PF01302;PF16641; P49230 CHOYP_PROF.2.2 m.41295 sp PROF_ENTHI 32.99 97 64 1 24 119 22 118 5.20E-09 54.3 PROF_ENTHI reviewed Profilin 0 Entamoeba histolytica 130 0 GO:0005737; GO:0005856 0 0 0 PF00235; P82596 CHOYP_MFN2.1.1 m.15293 sp PLC_HALLA 26.241 141 90 4 32 171 2 129 5.20E-11 60.8 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q63604 CHOYP_BM1_36790.1.1 m.19945 sp NTRK2_RAT 28.824 170 115 3 28 195 651 816 5.20E-13 76.6 NTRK2_RAT reviewed BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Trk-B) Ntrk2 Trkb Rattus norvegicus (Rat) 821 "activation of adenylate cyclase activity [GO:0007190]; activation of MAPKK activity [GO:0000186]; activation of phospholipase C activity [GO:0007202]; aging [GO:0007568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; central nervous system neuron development [GO:0021954]; cerebral cortex development [GO:0021987]; inflammatory response [GO:0006954]; learning [GO:0007612]; long-term memory [GO:0007616]; negative regulation of neuron apoptotic process [GO:0043524]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of glucocorticoid receptor signaling pathway [GO:2000324]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; protein autophosphorylation [GO:0046777]; Ras protein signal transduction [GO:0007265]; regulation of dendrite development [GO:0050773]; regulation of GTPase activity [GO:0043087]; regulation of MAPK cascade [GO:0043408]; regulation of neurotransmitter secretion [GO:0046928]; response to auditory stimulus [GO:0010996]; response to light stimulus [GO:0009416]; small GTPase mediated signal transduction [GO:0007264]" GO:0000139; GO:0000186; GO:0001764; GO:0004675; GO:0004714; GO:0005030; GO:0005524; GO:0005737; GO:0005791; GO:0005886; GO:0005887; GO:0006954; GO:0007190; GO:0007202; GO:0007264; GO:0007265; GO:0007568; GO:0007612; GO:0007616; GO:0008284; GO:0009416; GO:0009986; GO:0010008; GO:0010628; GO:0010976; GO:0010996; GO:0014068; GO:0014069; GO:0021954; GO:0021987; GO:0030182; GO:0030424; GO:0030425; GO:0030426; GO:0030971; GO:0031547; GO:0042803; GO:0043025; GO:0043087; GO:0043121; GO:0043197; GO:0043204; GO:0043408; GO:0043410; GO:0043524; GO:0043679; GO:0046777; GO:0046928; GO:0048011; GO:0048403; GO:0048786; GO:0050772; GO:0050773; GO:0051968; GO:0060076; GO:0060175; GO:0071356; GO:1990090; GO:1990416; GO:2000324 0 0 0 PF07679;PF13855;PF07714;PF16920; Q6GM59 CHOYP_MOT11.1.1 m.1311 sp MOT12_XENLA 29.455 404 271 6 8 407 17 410 5.20E-50 178 MOT12_XENLA reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) 460 creatine transmembrane transport [GO:1902598] GO:0005308; GO:0005887; GO:0015293; GO:1902598 0 0 cd06174; PF07690; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.10.34 m.29731 sp VWDE_HUMAN 25.085 295 201 8 592 871 800 1089 5.20E-16 87.4 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q95ND5 CHOYP_LOC100638885.1.4 m.28187 sp CASP3_PIG 31.138 167 87 3 102 265 32 173 5.20E-14 75.9 CASP3_PIG reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Sus scrofa (Pig) 277 erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182] GO:0005634; GO:0005737; GO:0030182; GO:0030216; GO:0030218; GO:0097194; GO:0097200 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208436.10.32 m.38665 sp HS12B_HUMAN 29.431 615 363 10 24 573 62 670 5.20E-95 308 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BYK8 CHOYP_LOC583716.2.4 m.27243 sp HELZ2_HUMAN 29.081 1654 973 50 553 2136 1117 2640 5.20E-180 614 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9PU85 CHOYP_ZGC_153997.2.2 m.59740 sp PIM3_COTJA 65.318 173 59 1 27 198 32 204 5.20E-75 233 PIM3_COTJA reviewed Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (qpim) PIM3 PIM-3 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 323 negative regulation of apoptotic process [GO:0043066] GO:0004674; GO:0005524; GO:0005737; GO:0043066 0 0 0 PF00069; Q9SB50 CHOYP_AP4M1.1.1 m.36172 sp AP4M_ARATH 31.234 397 245 12 2 380 1 387 5.20E-55 190 AP4M_ARATH reviewed AP-4 complex subunit mu (Adaptor protein complex AP-4 subunit mu) (Adaptor protein-4 mu-adaptin) (Adaptor-related protein complex 4 subunit mu) (At-muC-Ad) (Mu4-adaptin) AP4M CLH At4g24550 F22K18.250 Arabidopsis thaliana (Mouse-ear cress) 451 intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005802; GO:0005829; GO:0005905; GO:0006886; GO:0016192; GO:0030124; GO:0030131 0 0 0 PF00928;PF01217; Q9Z1J2 CHOYP_NEK4.6.8 m.52424 sp NEK4_MOUSE 41.797 256 146 3 31 285 11 264 5.20E-58 211 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; C3XVM1 CHOYP_GATC.1.2 m.2975 sp GATC_BRAFL 56.667 120 52 0 10 129 17 136 5.21E-42 139 GATC_BRAFL reviewed "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-)" BRAFLDRAFT_270748 Branchiostoma floridae (Florida lancelet) (Amphioxus) 149 glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of translational fidelity [GO:0006450] GO:0005524; GO:0005739; GO:0006450; GO:0030956; GO:0032543; GO:0050567; GO:0070681 0 0 0 PF02686; H2A0L1 CHOYP_TYRO2.4.5 m.43848 sp TYRO2_PINMG 29.945 364 221 10 58 395 55 410 5.21E-34 138 TYRO2_PINMG reviewed Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) 0 Pinctada margaritifera (Black-lipped pearl oyster) 456 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; O70277 CHOYP_TRIM3.10.58 m.14523 sp TRIM3_RAT 23.529 272 184 9 175 435 477 735 5.21E-10 65.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P00978 CHOYP_AMBP.1.1 m.4794 sp AMBP_BOVIN 33.108 148 74 8 118 258 208 337 5.21E-08 56.6 AMBP_BOVIN reviewed Protein AMBP [Cleaved into: Alpha-1-microglobulin; Inter-alpha-trypsin inhibitor light chain (ITI-LC) (BI-14) (Bikunin) (Cumulus extracellular matrix-stabilizing factor) (ESF) (HI-30); Trypstatin] AMBP ITIL Bos taurus (Bovine) 352 protein-chromophore linkage [GO:0018298] GO:0004867; GO:0005576; GO:0005886; GO:0018298; GO:0019862; GO:0020037; GO:0036094; GO:0042803 0 0 0 PF00014;PF00061; P30599 CHOYP_AGAP_AGAP001748.1.2 m.39011 sp CHS2_USTMA 27.805 410 202 19 55 388 542 933 5.21E-20 99 CHS2_USTMA reviewed Chitin synthase 2 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 2) CHS2 UMAG_04290 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 1074 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0030659; GO:0071555 0 0 0 PF01644;PF08407;PF13632; P51910 CHOYP_LOC100370738.1.1 m.30463 sp APOD_MOUSE 44.253 174 95 2 30 202 14 186 5.21E-43 145 APOD_MOUSE reviewed Apolipoprotein D (Apo-D) (ApoD) Apod Mus musculus (Mouse) 189 aging [GO:0007568]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246] GO:0000302; GO:0005215; GO:0005615; GO:0005622; GO:0005783; GO:0006006; GO:0006629; GO:0007420; GO:0007568; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0042493; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405 0 0 0 PF08212; P52556 CHOYP_LOC100374912.1.1 m.51922 sp BLVRB_BOVIN 27.861 201 123 7 2 199 5 186 5.21E-15 73.9 BLVRB_BOVIN reviewed Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) BLVRB Bos taurus (Bovine) 206 heme catabolic process [GO:0042167] GO:0004074; GO:0005654; GO:0005829; GO:0005886; GO:0042167; GO:0042602; GO:0070062 0 0 0 PF13460; P62752 CHOYP_ASTER.4.4 m.30482 sp RL23A_RAT 64.865 74 26 0 49 122 31 104 5.21E-24 94 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P70031 CHOYP_CCKAR.6.6 m.55706 sp CCKAR_XENLA 23.209 349 246 12 81 416 73 412 5.21E-15 80.1 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q6NUB2 CHOYP_LOC592411.1.1 m.19664 sp CW15A_XENLA 70 230 54 5 17 233 1 228 5.21E-90 267 CW15A_XENLA reviewed Protein CWC15 homolog A cwc15-a Xenopus laevis (African clawed frog) 228 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003723; GO:0005634; GO:0005681 0 0 0 PF04889; Q70CQ4 CHOYP_BRAFLDRAFT_119038.1.1 m.49061 sp UBP31_HUMAN 39.643 280 154 5 173 444 126 398 5.21E-57 207 UBP31_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.4.19.12) (Deubiquitinating enzyme 31) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) USP31 KIAA1203 Homo sapiens (Human) 1352 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0005634; GO:0006511; GO:0016579 0 0 0 PF00443; Q7KVW5 CHOYP_LOC100165930.1.1 m.843 sp KCNN_DROME 34.725 455 287 6 23 471 429 879 5.21E-91 300 KCNN_DROME reviewed Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) 927 potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057] GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016021; GO:0016057; GO:0016286; GO:0043025 0 0 0 PF02888;PF07885;PF03530; Q7L9B9 CHOYP_EEPD1.1.1 m.54277 sp EEPD1_HUMAN 40.172 580 305 12 1 570 1 548 5.21E-134 405 EEPD1_HUMAN reviewed Endonuclease/exonuclease/phosphatase family domain-containing protein 1 EEPD1 KIAA1706 Homo sapiens (Human) 569 DNA repair [GO:0006281] GO:0003677; GO:0006281 0 0 0 0 Q7Z5L3 CHOYP_C1QL2.28.32 m.55396 sp C1QL2_HUMAN 32.576 132 81 3 288 417 160 285 5.21E-10 63.5 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q7ZV00 CHOYP_OTUD6B.2.2 m.41784 sp OTU6B_DANRE 25.877 228 131 9 351 575 99 291 5.21E-10 65.1 OTU6B_DANRE reviewed OTU domain-containing protein 6B (EC 3.4.19.12) otud6b zgc:56305 Danio rerio (Zebrafish) (Brachydanio rerio) 293 0 GO:0036459 0 0 0 PF02338; Q7ZY86 CHOYP_LOC100374493.1.1 m.14259 sp TM168_XENLA 37.126 668 419 1 14 680 33 700 5.21E-164 490 TM168_XENLA reviewed Transmembrane protein 168 tmem168 Xenopus laevis (African clawed frog) 700 0 GO:0016021 0 0 0 0 Q8TCT0 CHOYP_SPHK2.2.2 m.65471 sp CERK1_HUMAN 34.518 197 128 1 109 305 125 320 5.21E-32 132 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q90YI3 CHOYP_SYMM.1.1 m.9409 sp SYMM_TAKRU 45.582 498 262 5 26 514 39 536 5.21E-154 456 SYMM_TAKRU reviewed "Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS)" mars2 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 590 methionyl-tRNA aminoacylation [GO:0006431] GO:0004825; GO:0005524; GO:0005739; GO:0005759; GO:0006431 0 0 0 PF09334; Q9ET47 CHOYP_LOC100632832.1.1 m.45608 sp ESPN_MOUSE 41.566 332 188 5 1 330 1 328 5.21E-70 249 ESPN_MOUSE reviewed Espin (Ectoplasmic specialization protein) Espn Mus musculus (Mouse) 871 actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; locomotory behavior [GO:0007626]; negative regulation of cytoskeleton organization [GO:0051494]; parallel actin filament bundle assembly [GO:0030046]; positive regulation of filopodium assembly [GO:0051491]; sensory perception of sound [GO:0007605] GO:0005737; GO:0005902; GO:0005903; GO:0007605; GO:0007626; GO:0015629; GO:0017124; GO:0030046; GO:0030054; GO:0031941; GO:0032421; GO:0032426; GO:0043197; GO:0051015; GO:0051017; GO:0051491; GO:0051494; GO:0051639 0 0 0 PF12796;PF02205; A4IF63 CHOYP_LOC101163547.2.3 m.47859 sp TRIM2_BOVIN 20.755 318 217 7 46 336 435 744 5.22E-12 70.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P02554 CHOYP_LOC373275.4.7 m.47548 sp TBB_PIG 98.37 184 3 0 1 184 73 256 5.22E-133 382 TBB_PIG reviewed Tubulin beta chain (Beta-tubulin) 0 Sus scrofa (Pig) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P55259 CHOYP_LOC100202447.1.1 m.26085 sp GP2_HUMAN 31.579 190 111 8 1 184 1 177 5.22E-14 77.4 GP2_HUMAN reviewed Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) (ZAP75) GP2 Homo sapiens (Human) 537 0 GO:0005886; GO:0031225; GO:0070062 0 0 0 PF00100; P62909 CHOYP_BRAFLDRAFT_56803.1.1 m.23114 sp RS3_RAT 90.909 143 13 0 1 143 5 147 5.22E-89 263 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; Q04336 CHOYP_LOC100636110.1.2 m.5041 sp YM54_YEAST 38.421 380 199 8 6 365 576 940 5.22E-72 247 YM54_YEAST reviewed Uncharacterized protein YMR196W YMR196W YM9646.09 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1088 oligosaccharide metabolic process [GO:0009311]; protein N-linked glycosylation [GO:0006487] GO:0004573; GO:0006487; GO:0009311 0 0 0 0 Q25390 CHOYP_KLH13.1.1 m.45401 sp SCRA_LIMPO 34.694 98 64 0 16 113 662 759 5.22E-14 70.9 SCRA_LIMPO reviewed Alpha-scruin 0 Limulus polyphemus (Atlantic horseshoe crab) 918 0 0 0 0 0 PF01344; Q28CF8 CHOYP_ENTPD4.1.1 m.15533 sp ENTP7_XENTR 42.288 577 299 9 29 587 14 574 5.22E-164 485 ENTP7_XENTR reviewed Ectonucleoside triphosphate diphosphohydrolase 7 (NTPDase 7) (EC 3.6.1.-) entpd7 TGas060f02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 610 0 GO:0016021; GO:0016787; GO:0030659; GO:0046872 0 0 0 PF01150; Q58EM4 CHOYP_LOC100372967.1.1 m.16378 sp ARMT1_DANRE 46.083 434 225 2 6 430 9 442 5.22E-138 405 ARMT1_DANRE reviewed Protein-glutamate O-methyltransferase (EC 2.1.1.-) (Acidic residue methyltransferase 1) armt1 zgc:110816 Danio rerio (Zebrafish) (Brachydanio rerio) 448 methylation [GO:0032259]; protein methylation [GO:0006479]; regulation of response to DNA damage stimulus [GO:2001020] GO:0006479; GO:0008757; GO:0032259; GO:0051998; GO:2001020 0 0 0 PF01937; Q71MB6 CHOYP_BRAFLDRAFT_134943.1.1 m.4731 sp SO4C1_RAT 38.047 686 409 7 38 714 15 693 5.22E-159 481 SO4C1_RAT reviewed Solute carrier organic anion transporter family member 4C1 (Solute carrier family 21 member 20) Slco4c1 Oatp4c1 Slc21a20 Rattus norvegicus (Rat) 724 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; sodium-independent organic anion transport [GO:0043252]; spermatogenesis [GO:0007283]; transport [GO:0006810] GO:0005215; GO:0005887; GO:0006810; GO:0007275; GO:0007283; GO:0015347; GO:0016021; GO:0016323; GO:0030154; GO:0043252 0 0 cd06174; PF07648;PF03137; Q80V70 CHOYP_MEGF6.6.59 m.4450 sp MEGF6_MOUSE 38.535 314 176 12 148 457 599 899 5.22E-37 148 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8BRH4 CHOYP_MLL3.3.3 m.48649 sp KMT2C_MOUSE 28.669 586 325 19 4 529 1143 1695 5.22E-38 162 KMT2C_MOUSE reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog) Kmt2c Mll3 Mus musculus (Mouse) 4903 "eyelid development in camera-type eye [GO:0061029]; histone methylation [GO:0016571]; multicellular organism growth [GO:0035264]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; single fertilization [GO:0007338]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0007338; GO:0008270; GO:0010468; GO:0016571; GO:0016746; GO:0035097; GO:0035264; GO:0042800; GO:0044666; GO:0044822; GO:0048146; GO:0061029 0 0 0 PF05965;PF05964;PF00628;PF00856; Q8WP23 CHOYP_LOC100892519.4.4 m.44989 sp BOLL_MACFA 41.546 207 77 9 1 205 38 202 5.22E-35 129 BOLL_MACFA reviewed Protein boule-like BOLL QtsA-21032 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 283 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of translation [GO:0006417]; spermatogenesis [GO:0007283] GO:0000166; GO:0003723; GO:0005737; GO:0006417; GO:0007275; GO:0007283; GO:0030154 0 0 0 PF00076; Q99M80 CHOYP_PTPRT.8.45 m.34312 sp PTPRT_MOUSE 35.835 413 223 9 412 786 758 1166 5.22E-61 228 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9JL15 CHOYP_LEG8.1.2 m.25640 sp LEG8_MOUSE 29.565 230 126 5 42 239 53 278 5.22E-22 97.1 LEG8_MOUSE reviewed Galectin-8 (Gal-8) (LGALS-8) Lgals8 Mus musculus (Mouse) 316 plasma cell differentiation [GO:0002317]; T cell costimulation [GO:0031295]; xenophagy [GO:0098792] GO:0002317; GO:0005829; GO:0016020; GO:0030246; GO:0031295; GO:0070062; GO:0098792 0 0 0 PF00337; Q9MYP6 CHOYP_DHB14.1.1 m.13441 sp DHB14_BOVIN 50 258 124 2 19 276 4 256 5.22E-86 261 DHB14_BOVIN reviewed 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) HSD17B14 DHRS10 SDR3 Bos taurus (Bovine) 270 steroid catabolic process [GO:0006706] GO:0004303; GO:0005829; GO:0006706; GO:0047045 0 0 0 0 Q9Y345 CHOYP_SC6A7.1.1 m.64266 sp SC6A5_HUMAN 42.017 595 338 6 25 614 179 771 5.22E-171 510 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; O75197 CHOYP_LRP5.3.3 m.60389 sp LRP5_HUMAN 32.727 275 173 7 41 310 341 608 5.23E-36 145 LRP5_HUMAN reviewed Low-density lipoprotein receptor-related protein 5 (LRP-5) LRP5 LR3 LRP7 Homo sapiens (Human) 1615 "adipose tissue development [GO:0060612]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in patterning of blood vessels [GO:1902262]; beta-catenin destruction complex disassembly [GO:1904886]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling involved in mammary gland development [GO:0060764]; cell migration involved in gastrulation [GO:0042074]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; glucose catabolic process [GO:0006007]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; osteoblast development [GO:0002076]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of bone remodeling [GO:0046850]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; retinal blood vessel morphogenesis [GO:0061304]; retina morphogenesis in camera-type eye [GO:0060042]; somatic stem cell population maintenance [GO:0035019]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]" GO:0001702; GO:0002053; GO:0002076; GO:0005739; GO:0005783; GO:0005886; GO:0006007; GO:0006897; GO:0008203; GO:0008217; GO:0008284; GO:0009952; GO:0016021; GO:0016055; GO:0017147; GO:0033690; GO:0035019; GO:0035426; GO:0042074; GO:0042632; GO:0042733; GO:0042813; GO:0042981; GO:0043235; GO:0044332; GO:0045600; GO:0045668; GO:0045840; GO:0045893; GO:0045944; GO:0046849; GO:0046850; GO:0048539; GO:0051091; GO:0060033; GO:0060042; GO:0060070; GO:0060349; GO:0060444; GO:0060612; GO:0060764; GO:0060828; GO:0061178; GO:0061304; GO:0071901; GO:0071936; GO:1902262; GO:1904886; GO:1904928; GO:1990851; GO:1990909 0 0 0 PF00057;PF00058; P04755 CHOYP_LOC100533245.5.6 m.38133 sp ACH3_DROME 51.093 503 228 7 28 522 24 516 5.23E-161 471 ACH3_DROME reviewed Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) nAChRbeta1 Acr64B AcrD ard nAcRbeta-64B CG11348 Drosophila melanogaster (Fruit fly) 521 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P53440 CHOYP_LOC100200547.1.1 m.1053 sp CALMF_NAEGR 55.629 151 66 1 1 151 6 155 5.23E-55 172 CALMF_NAEGR reviewed "Calmodulin, flagellar (CAM-1)" CAM1 Naegleria gruberi (Amoeba) 155 0 GO:0005509; GO:0031514 0 0 0 PF13499; Q29496 CHOYP_CP341.1.1 m.4788 sp CP3AO_SHEEP 40.681 499 283 9 3 498 8 496 5.23E-133 397 CP3AO_SHEEP reviewed Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) CYP3A24 Ovis aries (Sheep) 503 0 GO:0004497; GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q2YDJ8 CHOYP_LOC100891939.3.7 m.24772 sp KMT5A_BOVIN 32.54 126 66 4 67 175 226 349 5.23E-14 72.4 KMT5A_BOVIN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A SETD8 Bos taurus (Bovine) 352 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0005634; GO:0005694; GO:0006351; GO:0007067; GO:0016279; GO:0018024; GO:0018026; GO:0043516; GO:0051301 0 0 0 PF00856; Q32KY9 CHOYP_BRAFLDRAFT_117049.1.1 m.12884 sp NSE2_BOVIN 31.356 236 145 6 8 233 19 247 5.23E-29 112 NSE2_BOVIN reviewed E3 SUMO-protein ligase NSE2 (EC 6.3.2.-) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) NSMCE2 MMS21 Bos taurus (Bovine) 248 cell division [GO:0051301]; cellular senescence [GO:0090398]; double-strand break repair via homologous recombination [GO:0000724]; mitotic nuclear division [GO:0007067]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000724; GO:0000781; GO:0004842; GO:0007067; GO:0008270; GO:0016605; GO:0016874; GO:0019789; GO:0030915; GO:0034184; GO:0045842; GO:0051301; GO:0090398 PATHWAY: Protein modification; protein sumoylation. 0 0 PF11789; Q32LQ4 CHOYP_BRAFLDRAFT_90098.2.4 m.5630 sp BHMT1_DANRE 33.333 351 204 13 15 352 4 337 5.23E-44 159 BHMT1_DANRE reviewed Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) bhmt wu:fb53h01 zgc:123027 Danio rerio (Zebrafish) (Brachydanio rerio) 400 amino-acid betaine catabolic process [GO:0006579]; digestive system development [GO:0055123]; methionine biosynthetic process [GO:0009086]; type B pancreatic cell development [GO:0003323] GO:0003323; GO:0005829; GO:0006579; GO:0008270; GO:0008898; GO:0009086; GO:0047150; GO:0055123 PATHWAY: Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.; PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. 0 0 PF02574; Q6DIL6 CHOYP_LOC100378692.1.1 m.62182 sp F124A_XENTR 37.855 317 181 5 51 365 2 304 5.23E-67 223 F124A_XENTR reviewed Protein FAM124A fam124a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 503 0 0 0 0 0 PF15067; Q6GQD3 CHOYP_COX3.3.3 m.31130 sp RB24A_XENLA 54.468 235 72 11 6 218 4 225 5.23E-63 198 RB24A_XENLA reviewed RNA-binding protein 24-A (RNA-binding motif protein 24-A) (RRM domain-containing protein SEB-4) (SEB-4) (Xseb-4) rbm24-a Xenopus laevis (African clawed frog) 225 cell differentiation [GO:0030154]; regulation of mRNA stability [GO:0043488]; regulation of myotube differentiation [GO:0010830] GO:0000166; GO:0003730; GO:0005634; GO:0005737; GO:0010830; GO:0030154; GO:0043488 0 0 0 PF00076; Q7M456 CHOYP_LOC100114608.1.2 m.22363 sp RNOY_CRAGI 33.005 203 125 7 63 256 3 203 5.23E-29 113 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q8BUH7 CHOYP_RNF26.1.1 m.56545 sp RNF26_MOUSE 37.383 107 55 4 330 428 322 424 5.23E-14 77 RNF26_MOUSE reviewed Ring finger protein 26 Rnf26 Mus musculus (Mouse) 424 0 GO:0008270; GO:0016021 0 0 0 0 Q8N4P6 CHOYP_LOC585585.1.1 m.28772 sp LRC71_HUMAN 32.99 97 63 1 4 98 449 545 5.23E-13 67 LRC71_HUMAN reviewed Leucine-rich repeat-containing protein 71 LRRC71 C1orf92 Homo sapiens (Human) 559 0 0 0 0 0 PF13516; Q9NZN5 CHOYP_LOC100644321.2.7 m.23251 sp ARHGC_HUMAN 43.702 389 201 8 610 983 755 1140 5.23E-80 294 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q9TU19 CHOYP_LOC100375699.2.2 m.55362 sp NPHP1_CANLF 40.347 518 299 6 229 745 50 558 5.23E-132 406 NPHP1_CANLF reviewed Nephrocystin-1 (Fragment) NPHP1 NPH1 Canis lupus familiaris (Dog) (Canis familiaris) 565 cell differentiation [GO:0030154]; cell projection organization [GO:0030030]; spermatogenesis [GO:0007283] GO:0005737; GO:0005856; GO:0005911; GO:0005912; GO:0005923; GO:0005929; GO:0007283; GO:0030030; GO:0030154 0 0 0 PF00018; A0JM12 CHOYP_DRPR.2.2 m.62931 sp MEG10_XENTR 30.926 1080 592 20 1 949 1 1057 5.24E-146 465 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A6NI56 CHOYP_LOC100370844.1.2 m.30341 sp CC154_HUMAN 20.911 593 378 15 197 765 74 599 5.24E-12 73.6 CC154_HUMAN reviewed Coiled-coil domain-containing protein 154 CCDC154 Homo sapiens (Human) 674 0 GO:0005769 0 0 0 PF15450; B5DGL6 CHOYP_RS3A.15.15 m.63175 sp RS3A_SALSA 84.177 158 25 0 4 161 1 158 5.24E-92 271 RS3A_SALSA reviewed 40S ribosomal protein S3a rps3a Salmo salar (Atlantic salmon) 266 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P16303 CHOYP_EST1C.2.2 m.51703 sp CES1D_RAT 36.275 510 265 16 20 495 34 517 5.24E-81 265 CES1D_RAT reviewed Carboxylesterase 1D (Carboxyesterase ES-10) (Carboxylesterase 3) (EC 3.1.1.1) (EC 3.1.1.67) (ES-HVEL) (Fatty acid ethyl ester synthase) (FAEE synthase) (Liver carboxylesterase 10) (pI 6.1 esterase) Ces1d Ces3 Rattus norvegicus (Rat) 565 acylglycerol catabolic process [GO:0046464] GO:0004771; GO:0004806; GO:0005615; GO:0005788; GO:0005811; GO:0005829; GO:0030339; GO:0046464; GO:0052689 0 0 0 PF00135; P23206 CHOYP_C1QL3.4.5 m.58786 sp COAA1_BOVIN 31.25 144 84 6 60 202 543 672 5.24E-08 55.5 COAA1_BOVIN reviewed Collagen alpha-1(X) chain COL10A1 Bos taurus (Bovine) 674 0 GO:0005576; GO:0005578; GO:0005581 0 0 0 PF00386;PF01391; P70031 CHOYP_LOC100331465.1.3 m.25336 sp CCKAR_XENLA 24.194 372 229 15 50 399 69 409 5.24E-12 70.9 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q06852 CHOYP_NEMVEDRAFT_V1G198667.13.15 m.55267 sp SLAP1_CLOTH 31.445 512 305 16 212 688 1516 2016 5.24E-21 103 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q3UIR3 CHOYP_PAR14.8.17 m.35893 sp DTX3L_MOUSE 57.222 180 75 2 815 993 569 747 5.24E-61 225 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q3ZBK2 CHOYP_F213A.1.1 m.56030 sp F213A_BOVIN 51.049 143 66 2 1 139 76 218 5.24E-43 144 F213A_BOVIN reviewed Redox-regulatory protein FAM213A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) FAM213A PAMM Bos taurus (Bovine) 218 oxidation-reduction process [GO:0055114]; regulation of osteoclast differentiation [GO:0045670] GO:0005737; GO:0005739; GO:0016209; GO:0045670; GO:0055114; GO:0070062 0 0 0 PF13911; Q4R3B7 CHOYP_ISCW_ISCW021371.1.1 m.23571 sp SLNL1_MACFA 32.877 73 48 1 53 125 235 306 5.24E-06 48.5 SLNL1_MACFA reviewed Schlafen-like protein 1 SLFNL1 QtsA-18087 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 404 0 GO:0005524 0 0 0 PF04326; Q5XGP7 CHOYP_SKA2A.1.3 m.24186 sp SKA2A_XENLA 38.655 119 63 3 9 119 99 215 5.24E-16 82.8 SKA2A_XENLA reviewed Src kinase-associated phosphoprotein 2-A skap2-a Xenopus laevis (African clawed frog) 330 B cell activation [GO:0042113] GO:0005737; GO:0042113 0 0 0 PF00169;PF00018; Q6INU7 CHOYP_AAEL_AAEL006322.3.3 m.51696 sp FRRS1_XENLA 28.358 670 370 21 7 654 8 589 5.24E-86 284 FRRS1_XENLA reviewed Putative ferric-chelate reductase 1 (EC 1.-.-.-) frrs1 Xenopus laevis (African clawed frog) 590 0 GO:0016021; GO:0016491 0 0 cd08544; PF03188;PF03351;PF02014; Q7PCJ9 CHOYP_BRAFLDRAFT_285620.3.6 m.37912 sp SAT2_PIG 32.895 152 89 4 40 181 20 168 5.24E-22 90.5 SAT2_PIG reviewed Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) SAT2 SSAT2 Sus scrofa (Pig) 170 putrescine catabolic process [GO:0009447] GO:0004145; GO:0005737; GO:0009447 PATHWAY: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. 0 0 PF00583; Q8K0U4 CHOYP_BRAFLDRAFT_208197.1.21 m.4635 sp HS12A_MOUSE 30.88 625 371 11 43 615 50 665 5.24E-90 296 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8MP06 CHOYP_BRAFLDRAFT_278918.4.5 m.39356 sp SNO1_TYRJA 35.897 117 73 1 2 118 22 136 5.24E-18 81.6 SNO1_TYRJA reviewed Senecionine N-oxygenase (SNO) (EC 1.14.13.101) sno1 Tyria jacobaeae (Cinnabar moth) 456 alkaloid metabolic process [GO:0009820]; oxidation-reduction process [GO:0055114]; protein homotetramerization [GO:0051289] GO:0004499; GO:0005576; GO:0009820; GO:0033784; GO:0050660; GO:0050661; GO:0051289; GO:0055114 0 0 0 PF00743; Q96RW7 CHOYP_PGBM.1.3 m.17823 sp HMCN1_HUMAN 26.836 1103 689 41 62 1137 483 1494 5.24E-64 243 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9V9W8 CHOYP_LOC100875705.1.1 m.10980 sp PYGO_DROME 70.787 89 26 0 187 275 726 814 5.24E-42 156 PYGO_DROME reviewed Protein pygopus (Protein gammy legs) pygo gam CG11518 Drosophila melanogaster (Fruit fly) 815 "delamination [GO:0060232]; dendrite morphogenesis [GO:0048813]; embryonic pattern specification [GO:0009880]; eye-antennal disc development [GO:0035214]; imaginal disc-derived wing expansion [GO:0048526]; neurogenesis [GO:0022008]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; segment polarity determination [GO:0007367]; transcription, DNA-templated [GO:0006351]; wing disc morphogenesis [GO:0007472]; Wnt signaling pathway [GO:0016055]" GO:0005634; GO:0006351; GO:0007367; GO:0007472; GO:0008270; GO:0009880; GO:0016055; GO:0022008; GO:0030177; GO:0035214; GO:0045944; GO:0048526; GO:0048813; GO:0060232 0 0 0 0 Q9VXX8 CHOYP_LOC100378054.4.4 m.63855 sp RL371_DROME 66.154 65 22 0 42 106 28 92 5.24E-25 93.6 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; Q9XZC0 CHOYP_TVAG_272280.1.2 m.25447 sp LCTA_LATTR 30 160 86 6 762 900 698 852 5.24E-10 67.4 LCTA_LATTR reviewed Alpha-latrocrustotoxin-Lt1a (Alpha-LCT-Lt1a) (Alpha-latrocrustotoxin) (Alpha-LCT) (Crusta1) (Fragment) 0 Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus) 1413 exocytosis [GO:0006887] GO:0005576; GO:0006887; GO:0016021; GO:0072556 0 0 0 PF12796;PF13606; Q9Y4L1 CHOYP_HYOU1.3.3 m.28442 sp HYOU1_HUMAN 43.75 208 108 3 2 207 739 939 5.24E-41 154 HYOU1_HUMAN reviewed Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) HYOU1 GRP170 ORP150 Homo sapiens (Human) 999 cellular response to hypoxia [GO:0071456]; ER to Golgi vesicle-mediated transport [GO:0006888]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; receptor-mediated endocytosis [GO:0006898]; response to endoplasmic reticulum stress [GO:0034976]; response to ischemia [GO:0002931] GO:0002931; GO:0005524; GO:0005576; GO:0005783; GO:0005788; GO:0005790; GO:0005925; GO:0006888; GO:0006898; GO:0016020; GO:0034663; GO:0034976; GO:0036498; GO:0051087; GO:0070062; GO:0071456; GO:0071682; GO:1903298; GO:1903382 0 0 0 PF00012; A7Y2W8 CHOYP_SC6A1.1.1 m.36547 sp SC6A9_XENLA 54.911 224 97 1 79 302 189 408 5.25E-78 252 SC6A9_XENLA reviewed Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) 633 amino acid transport [GO:0006865] GO:0005283; GO:0005328; GO:0005887; GO:0006865 0 0 0 PF00209; B6RSP1 CHOYP_LOC593558.2.4 m.23211 sp PKHA7_DANRE 38.431 255 118 4 9 234 15 259 5.25E-48 192 PKHA7_DANRE reviewed Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) (Heart adapter protein 1) plekha7 hadp1 Danio rerio (Zebrafish) (Brachydanio rerio) 1197 cardiac muscle cell differentiation [GO:0055007]; epithelial cell-cell adhesion [GO:0090136]; regulation of heart contraction [GO:0008016]; zonula adherens maintenance [GO:0045218] GO:0005737; GO:0005813; GO:0005915; GO:0008016; GO:0045218; GO:0055007; GO:0070097; GO:0090136 0 0 0 PF00169;PF00397; Q32NQ7 CHOYP_LOC100377462.1.1 m.27334 sp DAAF3_XENLA 43.041 467 259 3 61 526 12 472 5.25E-125 377 DAAF3_XENLA reviewed "Dynein assembly factor 3, axonemal" dnaaf3 Xenopus laevis (African clawed frog) 485 axonemal dynein complex assembly [GO:0070286]; motile cilium assembly [GO:0044458] GO:0005737; GO:0044458; GO:0070286 0 0 0 PF14737;PF14740; Q4V9P6 CHOYP_ADAL.1.1 m.57556 sp ADAL_DANRE 53.416 322 146 2 33 350 16 337 5.25E-122 358 ADAL_DANRE reviewed Adenosine deaminase-like protein (EC 3.5.4.-) adal zgc:109912 Danio rerio (Zebrafish) (Brachydanio rerio) 348 adenosine catabolic process [GO:0006154]; inosine biosynthetic process [GO:0046103]; nucleotide metabolic process [GO:0009117] GO:0004000; GO:0006154; GO:0009117; GO:0046103; GO:0046872 0 0 0 PF00962; Q566U4 CHOYP_CCHCR1.1.1 m.59142 sp KFA_DANRE 36.644 292 181 2 6 297 4 291 5.25E-75 234 KFA_DANRE reviewed Kynurenine formamidase (KFA) (KFase) (EC 3.5.1.9) (Arylformamidase) (N-formylkynurenine formamidase) (FKF) afmid zgc:112472 Danio rerio (Zebrafish) (Brachydanio rerio) 293 'de novo' NAD biosynthetic process from tryptophan [GO:0034354]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0004061; GO:0005634; GO:0005829; GO:0019441; GO:0034354 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03014}. 0 0 PF07859; Q60648 CHOYP_GM2A.2.3 m.19346 sp SAP3_MOUSE 34.579 107 68 2 5 110 86 191 5.25E-19 80.9 SAP3_MOUSE reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) Gm2a Mus musculus (Mouse) 193 ganglioside catabolic process [GO:0006689]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; neurological system process [GO:0050877]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; positive regulation of hydrolase activity [GO:0051345] GO:0004563; GO:0005319; GO:0005739; GO:0005764; GO:0005889; GO:0006689; GO:0007611; GO:0008047; GO:0009313; GO:0009898; GO:0016004; GO:0019915; GO:0032428; GO:0045179; GO:0050877; GO:0050885; GO:0051345; GO:0070062 0 0 0 PF02221; Q66KD0 CHOYP_BTBD17.1.1 m.52333 sp BTBDH_XENTR 28.137 263 162 11 41 294 39 283 5.25E-16 83.2 BTBDH_XENTR reviewed BTB/POZ domain-containing protein 17 btbd17 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 468 0 GO:0005576 0 0 0 PF07707;PF00651; Q6NT55 CHOYP_BRAFLDRAFT_61250.10.14 m.46081 sp CP4FN_HUMAN 42.767 477 252 10 44 509 56 522 5.25E-127 384 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q7M3Y3 CHOYP_TNNI.2.3 m.19311 sp TNNI_CHLNI 62.887 97 30 3 62 154 194 288 5.25E-30 113 TNNI_CHLNI reviewed Troponin I (TnI) 0 Chlamys nipponensis akazara (Akazara scallop) (Japanese scallop) 292 0 GO:0005861; GO:0046872 0 0 0 PF00992; Q7XPJ0 CHOYP_LOC373208.1.1 m.17490 sp KCBP_ORYSJ 43.887 638 296 20 1258 1858 616 1228 5.25E-119 412 KCBP_ORYSJ reviewed Kinesin-like calmodulin-binding protein homolog Os04g0666900 LOC_Os04g57140 OSJNBa0087O24.20 Oryza sativa subsp. japonica (Rice) 1248 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005871; GO:0007018; GO:0016491; GO:0016887 0 0 0 PF00373;PF09379;PF00225;PF00784; Q7ZXX1 CHOYP_CEACAM1.2.3 m.58736 sp CADM3_XENLA 24.125 257 177 8 73 328 60 299 5.25E-08 58.5 CADM3_XENLA reviewed Cell adhesion molecule 3 (Immunoglobulin superfamily member 4B) (IgSF4B) cadm3 igsf4b Xenopus laevis (African clawed frog) 394 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030054 0 0 0 PF08205;PF07679; Q8BKF1 CHOYP_LOC100024662.1.1 m.1590 sp RPOM_MOUSE 46.882 465 227 4 16 477 610 1057 5.25E-140 435 RPOM_MOUSE reviewed "DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)" Polrmt Mus musculus (Mouse) 1207 transcription from mitochondrial promoter [GO:0006390] GO:0003677; GO:0003899; GO:0005739; GO:0006390; GO:0042645; GO:0044822 0 0 0 PF00940;PF14700; Q8CFN2 CHOYP_SMP_082810.2.1.1 m.55540 sp CDC42_RAT 41.361 191 111 1 16 206 2 191 5.25E-48 158 CDC42_RAT reviewed Cell division control protein 42 homolog Cdc42 Rattus norvegicus (Rat) 191 actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; adherens junction organization [GO:0034332]; canonical Wnt signaling pathway [GO:0060070]; cardiac conduction system development [GO:0003161]; cellular protein localization [GO:0034613]; dendritic cell migration [GO:0036336]; endocytosis [GO:0006897]; epithelial cell-cell adhesion [GO:0090136]; epithelial-mesenchymal cell signaling [GO:0060684]; establishment of cell polarity [GO:0030010]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; heart contraction [GO:0060047]; keratinization [GO:0031424]; keratinocyte development [GO:0003334]; multicellular organism growth [GO:0035264]; negative regulation of gene expression [GO:0010629]; negative regulation of protein complex assembly [GO:0031333]; neuron fate determination [GO:0048664]; nuclear migration [GO:0007097]; organelle transport along microtubule [GO:0072384]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cell growth [GO:0030307]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of gene expression [GO:0010628]; positive regulation of hair follicle cell proliferation [GO:0071338]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of synapse structural plasticity [GO:0051835]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of exocytosis [GO:0017157]; regulation of filopodium assembly [GO:0051489]; regulation of mitotic nuclear division [GO:0007088]; regulation of protein catabolic process [GO:0042176]; regulation of protein heterodimerization activity [GO:0043497]; regulation of protein kinase activity [GO:0045859]; regulation of protein stability [GO:0031647]; response to glucose [GO:0009749]; small GTPase mediated signal transduction [GO:0007264]; sprouting angiogenesis [GO:0002040]; submandibular salivary gland formation [GO:0060661]; substantia nigra development [GO:0021762] GO:0000139; GO:0000322; GO:0002040; GO:0003161; GO:0003334; GO:0003924; GO:0005525; GO:0005815; GO:0005829; GO:0005886; GO:0005911; GO:0005925; GO:0006897; GO:0007015; GO:0007030; GO:0007088; GO:0007097; GO:0007264; GO:0009749; GO:0010628; GO:0010629; GO:0016020; GO:0017157; GO:0021762; GO:0030010; GO:0030141; GO:0030175; GO:0030307; GO:0030496; GO:0031069; GO:0031256; GO:0031274; GO:0031333; GO:0031424; GO:0031435; GO:0031647; GO:0032467; GO:0033138; GO:0034332; GO:0034613; GO:0035088; GO:0035264; GO:0036336; GO:0036464; GO:0042176; GO:0043005; GO:0043025; GO:0043085; GO:0043209; GO:0043497; GO:0043525; GO:0043552; GO:0045177; GO:0045740; GO:0045859; GO:0046330; GO:0046847; GO:0048664; GO:0051017; GO:0051233; GO:0051489; GO:0051683; GO:0051835; GO:0051988; GO:0060047; GO:0060070; GO:0060501; GO:0060661; GO:0060684; GO:0060789; GO:0061630; GO:0070062; GO:0071338; GO:0072384; GO:0072686; GO:0090135; GO:0090136; GO:0090316; GO:1900026 0 0 0 PF00071; Q8TEP8 CHOYP_CEP192.1.2 m.7869 sp CE192_HUMAN 29.667 1200 755 31 1510 2654 771 1936 5.25E-144 502 CE192_HUMAN reviewed Centrosomal protein of 192 kDa (Cep192) CEP192 KIAA1569 PP8407 Homo sapiens (Human) 1941 centrosome duplication [GO:0051298]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of phosphatase activity [GO:0010923]; spindle assembly [GO:0051225] GO:0000086; GO:0000242; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0010923; GO:0019902; GO:0051225; GO:0051298 0 0 0 0 Q91312 CHOYP_CRYAB.1.5 m.2659 sp CRYAB_LITCT 31.875 160 98 5 73 223 8 165 5.25E-17 78.6 CRYAB_LITCT reviewed Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 173 0 GO:0005212; GO:0042803; GO:0046872 0 0 0 PF00525;PF00011; Q9VGH7 CHOYP_BRAFLDRAFT_118473.3.3 m.40431 sp CLCN2_DROME 56.098 410 173 4 14 417 103 511 5.25E-151 461 CLCN2_DROME reviewed Chloride channel protein 2 (ClC-2) (DmClC-2) (Chloride channel-a) ClC-a CG31116 Drosophila melanogaster (Fruit fly) 1193 chloride transport [GO:0006821] GO:0005247; GO:0006821; GO:0015629; GO:0034707 0 0 0 PF00654; Q9Y383 CHOYP_BRAFLDRAFT_206907.5.11 m.19273 sp LC7L2_HUMAN 70.293 239 71 0 1 239 1 239 5.25E-123 365 LC7L2_HUMAN reviewed Putative RNA-binding protein Luc7-like 2 LUC7L2 CGI-59 CGI-74 Homo sapiens (Human) 392 mRNA splice site selection [GO:0006376] GO:0003729; GO:0005685; GO:0006376; GO:0016607; GO:0019899; GO:0044822; GO:0071004 0 0 0 PF03194; Q9Z0T0 CHOYP_LOC101168968.1.1 m.61773 sp TPMT_RAT 32.85 207 135 3 33 235 19 225 5.25E-32 120 TPMT_RAT reviewed Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) Tpmt Rattus norvegicus (Rat) 240 nucleobase-containing compound metabolic process [GO:0006139]; response to organic cyclic compound [GO:0014070]; response to testosterone [GO:0033574] GO:0005737; GO:0006139; GO:0008119; GO:0014070; GO:0033574 0 0 0 PF05724; Q9Z2D3 CHOYP_BRAFLDRAFT_96254.1.1 m.47860 sp DFNA5_MOUSE 23.32 253 181 8 43 290 1 245 5.25E-09 62 DFNA5_MOUSE reviewed Non-syndromic hearing impairment protein 5 homolog Dfna5 Dfna5h Mus musculus (Mouse) 512 apoptotic process [GO:0006915]; inner ear receptor cell differentiation [GO:0060113]; negative regulation of cell proliferation [GO:0008285]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; sensory perception of sound [GO:0007605] GO:0005737; GO:0006915; GO:0007605; GO:0008285; GO:0060113; GO:2001244 0 0 0 PF04598; A7Y2W8 CHOYP_LOC100375514.3.6 m.39059 sp SC6A9_XENLA 56.075 107 47 0 1 107 301 407 5.26E-38 140 SC6A9_XENLA reviewed Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) 633 amino acid transport [GO:0006865] GO:0005283; GO:0005328; GO:0005887; GO:0006865 0 0 0 PF00209; B2RU80 CHOYP_PTP10.2.3 m.39408 sp PTPRB_MOUSE 39.164 383 204 12 765 1136 1620 1984 5.26E-73 271 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; O08781 CHOYP_ZMAT3.1.1 m.16696 sp ZMAT3_RAT 31.457 302 128 9 614 907 51 281 5.26E-30 124 ZMAT3_RAT reviewed Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein) Zmat3 Pag608 Wig1 Rattus norvegicus (Rat) 289 cellular response to DNA damage stimulus [GO:0006974]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of apoptotic process [GO:0043065]; protein transport [GO:0015031]; regulation of growth [GO:0040008] GO:0002039; GO:0003723; GO:0005730; GO:0006974; GO:0008270; GO:0015031; GO:0040008; GO:0043065; GO:0044822; GO:0072332 0 0 0 PF12171; P11627 CHOYP_LOC101160163.1.2 m.20003 sp L1CAM_MOUSE 24.711 433 290 14 40 457 48 459 5.26E-24 110 L1CAM_MOUSE reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) L1cam Caml1 Mus musculus (Mouse) 1260 axon guidance [GO:0007411]; cell-cell adhesion mediated by integrin [GO:0033631]; cell surface receptor signaling pathway [GO:0007166]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; homotypic cell-cell adhesion [GO:0034109]; leukocyte cell-cell adhesion [GO:0007159]; neuron projection development [GO:0031175]; positive regulation of axon extension [GO:0045773]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of cell-cell adhesion [GO:0022409] GO:0005178; GO:0005886; GO:0005925; GO:0007156; GO:0007157; GO:0007159; GO:0007166; GO:0007411; GO:0009897; GO:0009986; GO:0016020; GO:0016021; GO:0022409; GO:0031175; GO:0033631; GO:0033691; GO:0034109; GO:0042734; GO:0042802; GO:0043195; GO:0043621; GO:0044295; GO:0045773; GO:0050850 0 0 0 PF13882;PF00041;PF07679; Q04832 CHOYP_ZCHC9.1.2 m.201 sp HEXP_LEIMA 33.333 99 53 2 94 192 38 123 5.26E-10 62 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q1L8J7 CHOYP_YAP.1.2 m.23387 sp YAP1_DANRE 36.556 331 137 12 1 281 135 442 5.26E-41 149 YAP1_DANRE reviewed Transcriptional coactivator YAP1 (Yes-associated protein 1) (zYAP) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) yap1 CH211-181P1.5-001 Danio rerio (Zebrafish) (Brachydanio rerio) 442 "dorsal/ventral axis specification [GO:0009950]; embryonic hemopoiesis [GO:0035162]; heart formation [GO:0060914]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0009950; GO:0010629; GO:0035162; GO:0043066; GO:0060914 0 0 0 PF00397; Q23023 CHOYP_DPSE_GA10675.1.1 m.23860 sp UNC51_CAEEL 63.664 333 100 3 1 313 1 332 5.26E-126 406 UNC51_CAEEL reviewed Serine/threonine-protein kinase unc-51 (EC 2.7.11.1) (Uncoordinated protein 51) unc-51 Y60A3A.1 Caenorhabditis elegans 856 apoptotic cell clearance [GO:0043277]; autophagy [GO:0006914]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cell migration [GO:0016477]; dauer larval development [GO:0040024]; determination of adult lifespan [GO:0008340]; embryo development ending in birth or egg hatching [GO:0009792]; nematode male tail tip morphogenesis [GO:0045138]; programmed cell death [GO:0012501]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon extension [GO:0030516]; regulation of cell size [GO:0008361]; regulation of multicellular organism growth [GO:0040014]; regulation of protein localization [GO:0032880] GO:0004672; GO:0004674; GO:0005524; GO:0006468; GO:0006914; GO:0007409; GO:0007411; GO:0008340; GO:0008361; GO:0009792; GO:0012501; GO:0016477; GO:0030424; GO:0030516; GO:0032880; GO:0040014; GO:0040024; GO:0043005; GO:0043025; GO:0043277; GO:0045138; GO:0046777; GO:0046872 0 0 0 PF12063;PF00069; Q24157 CHOYP_PHUM_PHUM278100.1.1 m.55818 sp BRN_DROME 33.191 235 150 3 92 323 56 286 5.26E-34 130 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q5RJ80 CHOYP_C1QL2.23.32 m.46727 sp CAPR2_DANRE 35.115 131 75 5 263 387 785 911 5.26E-11 68.2 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q6P7S1 CHOYP_LOC101065149.1.1 m.49591 sp ASAH1_RAT 50.806 372 177 3 19 386 22 391 5.26E-146 422 ASAH1_RAT reviewed Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylsphingosine amidohydrolase) Asah1 Rattus norvegicus (Rat) 394 lipid metabolic process [GO:0006629]; lung development [GO:0030324]; response to organic substance [GO:0010033] GO:0005764; GO:0006629; GO:0010033; GO:0017040; GO:0030324 0 0 0 PF02275;PF15508; Q8IYE1 CHOYP_LOC594533.1.1 m.58830 sp CCD13_HUMAN 35.861 778 411 22 2 756 3 715 5.26E-108 348 CCD13_HUMAN reviewed Coiled-coil domain-containing protein 13 CCDC13 Homo sapiens (Human) 715 cellular response to DNA damage stimulus [GO:0006974]; cytoplasmic microtubule organization [GO:0031122]; nonmotile primary cilium assembly [GO:0035058] GO:0005813; GO:0006974; GO:0031122; GO:0034451; GO:0035058; GO:0042995 0 0 0 0 Q8SX83 CHOYP_MINT.1.1 m.54605 sp SPEN_DROME 58.052 267 111 1 269 535 549 814 5.26E-94 348 SPEN_DROME reviewed Protein split ends spen CG18497 Drosophila melanogaster (Fruit fly) 5560 "axon guidance [GO:0007411]; compound eye development [GO:0048749]; defense response to fungus [GO:0050832]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of thoracic bristle planar orientation [GO:0048106]; glial cell fate determination [GO:0007403]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; maintenance of imaginal disc-derived wing hair orientation [GO:0035321]; mRNA splicing, via spliceosome [GO:0000398]; neuroblast fate determination [GO:0007400]; peripheral nervous system development [GO:0007422]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of transcription, DNA-templated [GO:0006355]; segment specification [GO:0007379]; sleep [GO:0030431]; transcription, DNA-templated [GO:0006351]; wing disc pattern formation [GO:0035222]; Wnt signaling pathway [GO:0016055]" GO:0000166; GO:0000398; GO:0003676; GO:0003723; GO:0005634; GO:0006351; GO:0006355; GO:0007173; GO:0007379; GO:0007400; GO:0007403; GO:0007411; GO:0007422; GO:0008586; GO:0016055; GO:0030177; GO:0030431; GO:0035222; GO:0035321; GO:0048106; GO:0048749; GO:0050832 0 0 0 PF00076;PF07744; Q960V3 CHOYP_LOC100647086.1.1 m.27655 sp MILT_DROME 36.486 148 71 6 79 206 666 810 5.26E-12 71.2 MILT_DROME reviewed Trafficking kinesin-binding protein milt (Protein milton) milt CG43227 Drosophila melanogaster (Fruit fly) 1122 axonal transport of mitochondrion [GO:0019896]; establishment of mitochondrion localization [GO:0051654]; mitochondrion distribution [GO:0048311]; Nebenkern assembly [GO:0007287]; oocyte dorsal/ventral axis specification [GO:0007310]; phototransduction [GO:0007602]; sensory perception of pain [GO:0019233]; sperm mitochondrion organization [GO:0030382] GO:0003777; GO:0005739; GO:0007287; GO:0007310; GO:0007602; GO:0017022; GO:0019233; GO:0019896; GO:0030382; GO:0048311; GO:0051654; GO:1904115 0 0 0 PF04849;PF12448; Q99MD9 CHOYP_BRAFLDRAFT_131259.1.1 m.49716 sp NASP_MOUSE 49.383 162 79 3 2 161 23 183 5.26E-32 123 NASP_MOUSE reviewed Nuclear autoantigenic sperm protein (NASP) Nasp Mus musculus (Mouse) 773 blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone exchange [GO:0043486]; protein transport [GO:0015031] GO:0000790; GO:0001824; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006335; GO:0006336; GO:0007049; GO:0008283; GO:0015031; GO:0042393; GO:0043234; GO:0043486; GO:0051879 0 0 0 PF10516; Q9BH04 CHOYP_LOC101280586.1.1 m.64390 sp KBRS1_MACFA 57.558 172 72 1 1 172 1 171 5.26E-69 212 KBRS1_MACFA reviewed NF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1) NKIRAS1 QflA-10220 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 192 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005737; GO:0007264; GO:0016020 0 0 0 PF00071; Q9CZJ2 CHOYP_BRAFLDRAFT_240123.6.6 m.60284 sp HS12B_MOUSE 36.364 352 172 10 11 311 61 411 5.26E-54 190 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9UJA9 CHOYP_ENPP5.1.1 m.25136 sp ENPP5_HUMAN 45.013 391 202 9 35 424 27 405 5.26E-110 337 ENPP5_HUMAN reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-) ENPP5 UNQ550/PRO1107 Homo sapiens (Human) 477 cell communication [GO:0007154]; metabolic process [GO:0008152] GO:0005576; GO:0005886; GO:0007154; GO:0008152; GO:0016021; GO:0016787; GO:0046872 0 0 0 PF01663; Q9WUQ1 CHOYP_ATS6.1.3 m.8385 sp ATS1_RAT 26.862 443 229 20 140 535 153 547 5.26E-26 117 ATS1_RAT reviewed A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) Adamts1 Rattus norvegicus (Rat) 967 cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to prostaglandin E stimulus [GO:0071380]; cellular response to vitamin D [GO:0071305]; ovulation [GO:0030728]; positive regulation of neuron projection development [GO:0010976]; tooth eruption [GO:0044691] GO:0004222; GO:0005578; GO:0008201; GO:0008270; GO:0010976; GO:0030728; GO:0031012; GO:0044691; GO:0071305; GO:0071374; GO:0071380 0 0 0 PF05986;PF01562;PF01421;PF00090; B3EWZ5 CHOYP_DMBT1.15.34 m.29008 sp MLRP1_ACRMI 42.358 229 114 6 119 339 2327 2545 5.27E-43 174 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B5XGE7 CHOYP_LOC594590.2.2 m.11915 sp TPC2L_SALSA 74.815 135 34 0 30 164 1 135 5.27E-74 221 TPC2L_SALSA reviewed Trafficking protein particle complex subunit 2-like protein trappc2l tpc2l Salmo salar (Atlantic salmon) 139 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0005783; GO:0005794; GO:0006888; GO:0048471 0 0 0 PF04628; B9A8D7 CHOYP_SPI2.8.37 m.4837 sp SPI2_CRAVI 35.802 81 50 2 16 96 4 82 5.27E-06 43.9 SPI2_CRAVI reviewed Serine protease inhibitor Cvsi-2 CVSI2 Crassostrea virginica (Eastern oyster) 85 0 GO:0004867; GO:0005576 0 0 0 0 D2GXS7 CHOYP_LOC100373444.21.79 m.24675 sp TRIM2_AILME 30.323 155 99 4 352 500 578 729 5.27E-10 65.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O17185 CHOYP_LOC100120322.2.3 m.1334 sp SUP9_CAEEL 55.556 306 126 4 1 305 1 297 5.27E-114 337 SUP9_CAEEL reviewed Two pore potassium channel protein sup-9 (Suppressor of unc-93 protein 9) (n2P38) sup-9 F34D6.3 Caenorhabditis elegans 329 potassium ion transport [GO:0006813]; regulation of muscle contraction [GO:0006937]; stabilization of membrane potential [GO:0030322] GO:0005267; GO:0005887; GO:0006813; GO:0006937; GO:0022841; GO:0030322; GO:0036195; GO:0055120 0 0 0 PF07885; O76050 CHOYP_LOC100533294.3.3 m.64945 sp NEUL1_HUMAN 55.769 52 22 1 469 519 521 572 5.27E-13 75.1 NEUL1_HUMAN reviewed E3 ubiquitin-protein ligase NEURL1 (EC 6.3.2.-) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) NEURL1 NEURL NEURL1A RNF67 Homo sapiens (Human) 574 brain development [GO:0007420]; cellular response to amino acid stimulus [GO:0071230]; lactation [GO:0007595]; negative regulation of cell proliferation [GO:0008285]; negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of synapse maturation [GO:0090129]; protein monoubiquitination [GO:0006513]; skeletal muscle tissue development [GO:0007519]; sperm axoneme assembly [GO:0007288]; sperm motility [GO:0030317] GO:0004842; GO:0005886; GO:0006513; GO:0007219; GO:0007288; GO:0007399; GO:0007420; GO:0007519; GO:0007595; GO:0008270; GO:0008285; GO:0014069; GO:0016874; GO:0030054; GO:0030317; GO:0043065; GO:0043197; GO:0043204; GO:0045183; GO:0045211; GO:0045741; GO:0045746; GO:0048170; GO:0048471; GO:0051491; GO:0060999; GO:0061630; GO:0071230; GO:0090129; GO:0097440 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07177; P22105 CHOYP_MEG11.7.25 m.38754 sp TENX_HUMAN 30.482 456 232 34 180 611 263 657 5.27E-34 144 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P40305 CHOYP_LOC101242540.1.2 m.6466 sp IFI27_HUMAN 48.485 99 40 2 139 237 30 117 5.27E-16 75.9 IFI27_HUMAN reviewed "Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a))" IFI27 Homo sapiens (Human) 119 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of protein export from nucleus [GO:0046825]; type I interferon signaling pathway [GO:0060337] GO:0000122; GO:0001102; GO:0005521; GO:0005637; GO:0005739; GO:0005741; GO:0006919; GO:0016021; GO:0046825; GO:0060337; GO:0097190 0 0 0 PF06140; Q03601 CHOYP_BRAFLDRAFT_87310.3.3 m.52709 sp NHL1_CAEEL 30.769 117 72 4 112 225 730 840 5.27E-07 53.5 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q06852 CHOYP_LOC100892997.1.1 m.16865 sp SLAP1_CLOTH 55.162 339 103 24 213 510 1499 1829 5.27E-26 119 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q08DF7 CHOYP_BRAFLDRAFT_212438.1.1 m.29117 sp PDE12_BOVIN 39.145 585 309 10 69 621 40 609 5.27E-134 408 PDE12_BOVIN reviewed "2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)" PDE12 Bos taurus (Bovine) 609 mRNA processing [GO:0006397] GO:0004535; GO:0005759; GO:0006397; GO:0046872 0 0 0 PF03372; Q56R14 CHOYP_LOC100370588.17.19 m.61003 sp TRI33_XENLA 26.126 222 123 8 13 221 185 378 5.27E-06 50.8 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5ZJ41 CHOYP_LOC100904946.1.1 m.3903 sp MARH5_CHICK 25.62 121 79 5 404 521 15 127 5.27E-06 52 MARH5_CHICK reviewed E3 ubiquitin-protein ligase MARCH5 (EC 6.3.2.-) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) MARCH5 RCJMB04_20o22 Gallus gallus (Chicken) 281 negative regulation of cell aging [GO:0090344]; positive regulation of mitochondrial fission [GO:0090141]; protein autoubiquitination [GO:0051865]; protein localization to mitochondrion [GO:0070585]; protein polyubiquitination [GO:0000209]; regulation of mitochondrial fission [GO:0090140] GO:0000209; GO:0004842; GO:0005741; GO:0005783; GO:0005789; GO:0008270; GO:0016021; GO:0016874; GO:0051865; GO:0070585; GO:0090140; GO:0090141; GO:0090344 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12906; Q642G4 CHOYP_BRAFLDRAFT_122688.1.1 m.21373 sp PEX14_RAT 39.13 230 129 5 33 261 24 243 5.27E-51 176 PEX14_RAT reviewed Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) Pex14 Rattus norvegicus (Rat) 376 "microtubule anchoring [GO:0034453]; negative regulation of protein binding [GO:0032091]; negative regulation of protein homotetramerization [GO:1901094]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription, DNA-templated [GO:0045892]; peroxisome organization [GO:0007031]; peroxisome transport along microtubule [GO:0036250]; protein homooligomerization [GO:0051260]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, substrate release [GO:0044721]; protein import into peroxisome matrix, translocation [GO:0016561]" GO:0003714; GO:0005730; GO:0005777; GO:0005778; GO:0007031; GO:0016021; GO:0016560; GO:0016561; GO:0032091; GO:0034453; GO:0036250; GO:0043234; GO:0043433; GO:0044721; GO:0045892; GO:0051260; GO:1901094 0 0 0 PF04695; Q6A098 CHOYP_SECISBP2L.1.1 m.52771 sp SBP2L_MOUSE 50.245 408 170 10 489 881 474 863 5.27E-104 356 SBP2L_MOUSE reviewed Selenocysteine insertion sequence-binding protein 2-like (SECIS-binding protein 2-like) Secisbp2l Kiaa0256 Mus musculus (Mouse) 1086 0 GO:0044822 0 0 0 PF01248; Q7T3N8 CHOYP_RL15.1.3 m.44233 sp RL15_CTEID 75.49 204 50 0 41 244 1 204 5.27E-114 328 RL15_CTEID reviewed 60S ribosomal protein L15 rpl15 Ctenopharyngodon idella (Grass carp) (Leuciscus idella) 204 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00827; Q80T91 CHOYP_CBG18730.1.1 m.2611 sp MEG11_MOUSE 35.135 296 161 19 254 541 366 638 5.27E-23 107 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8C7M3 CHOYP_LOC100373444.49.79 m.42404 sp TRIM9_MOUSE 21.659 217 157 5 4 211 159 371 5.27E-06 52.4 TRIM9_MOUSE reviewed E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (Tripartite motif-containing protein 9) Trim9 Kiaa0282 Mus musculus (Mouse) 817 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; synaptic vesicle exocytosis [GO:0016079] GO:0004842; GO:0005737; GO:0005856; GO:0008021; GO:0008270; GO:0016079; GO:0016874; GO:0030054; GO:0030425; GO:0042803; GO:0043161 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00041;PF00622;PF00643; Q8C8N3 CHOYP_VWC2.2.3 m.33526 sp VWC2_MOUSE 33.673 98 63 2 25 121 209 305 5.27E-08 53.5 VWC2_MOUSE reviewed Brorin (Brain-specific chordin-like protein) (CR (chordin-like cysteine-rich) domain-containing adhesive protein) (Cradin) (von Willebrand factor C domain-containing protein 2) Vwc2 Mus musculus (Mouse) 324 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of neuron differentiation [GO:0045666] GO:0005578; GO:0005604; GO:0005614; GO:0005615; GO:0010811; GO:0030054; GO:0030514; GO:0032281; GO:0045202; GO:0045666 0 0 0 PF00093; Q9H1K0 CHOYP_BRAFLDRAFT_215186.1.1 m.10642 sp RBNS5_HUMAN 41.553 515 254 8 5 494 8 500 5.27E-118 367 RBNS5_HUMAN reviewed Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20) RBSN ZFYVE20 Homo sapiens (Human) 784 blood coagulation [GO:0007596]; early endosome to Golgi transport [GO:0034498]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; Golgi to endosome transport [GO:0006895]; Golgi to lysosome transport [GO:0090160]; Golgi to vacuole transport [GO:0006896]; protein transport [GO:0015031]; regulation of Golgi organization [GO:1903358]; vacuole inheritance [GO:0000011] GO:0000011; GO:0005768; GO:0005829; GO:0005886; GO:0006895; GO:0006896; GO:0006897; GO:0007596; GO:0008270; GO:0010008; GO:0010009; GO:0015031; GO:0016197; GO:0017137; GO:0031901; GO:0034058; GO:0034498; GO:0043231; GO:0070062; GO:0090160; GO:1903358 0 0 0 PF01363;PF11464; Q9JLQ0 CHOYP_BRAFLDRAFT_90471.2.2 m.49430 sp CD2AP_MOUSE 42.169 249 123 6 1 229 1 248 5.27E-47 183 CD2AP_MOUSE reviewed CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1) Cd2ap Mets1 Mus musculus (Mouse) 637 cell division [GO:0051301]; cell migration [GO:0016477]; mitotic nuclear division [GO:0007067]; negative regulation of transforming growth factor beta1 production [GO:0032911]; positive regulation of protein localization to nucleus [GO:1900182]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of actin cytoskeleton reorganization [GO:2000249]; regulation of receptor-mediated endocytosis [GO:0048259]; single organismal cell-cell adhesion [GO:0016337]; vesicle organization [GO:0016050] GO:0001726; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0005938; GO:0007067; GO:0016050; GO:0016337; GO:0016477; GO:0017124; GO:0030139; GO:0031941; GO:0032911; GO:0043161; GO:0048259; GO:0048471; GO:0051301; GO:0070062; GO:1900182; GO:2000249 0 0 0 PF00018;PF14604; Q9Y2H2 CHOYP_LOC663138.1.1 m.7661 sp SAC2_HUMAN 47.581 372 166 6 1 364 417 767 5.27E-111 362 SAC2_HUMAN reviewed Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2) INPP5F KIAA0966 SAC2 MSTP007 MSTP047 Homo sapiens (Human) 1132 cardiac muscle hypertrophy in response to stress [GO:0014898]; clathrin-mediated endocytosis [GO:0072583]; negative regulation of axon regeneration [GO:0048681]; negative regulation of tyrosine phosphorylation of Stat3 protein [GO:0042518]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol catabolic process [GO:0031161]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of receptor recycling [GO:0001921]; regulation of cell motility [GO:2000145]; regulation of endocytic recycling [GO:2001135]; regulation of protein kinase B signaling [GO:0051896] GO:0001921; GO:0005769; GO:0005905; GO:0006661; GO:0008934; GO:0014898; GO:0031161; GO:0031901; GO:0034595; GO:0034596; GO:0042518; GO:0042803; GO:0045334; GO:0046856; GO:0048015; GO:0048681; GO:0051896; GO:0052832; GO:0052833; GO:0055037; GO:0072583; GO:2000145; GO:2001135 0 0 0 PF12456;PF02383; C6KFA3 CHOYP_LOC577191.1.1 m.25751 sp GP126_DANRE 28.499 593 369 16 692 1256 558 1123 5.28E-60 229 GP126_DANRE reviewed G-protein coupled receptor 126 gpr126 Danio rerio (Zebrafish) (Brachydanio rerio) 1185 cAMP-mediated signaling [GO:0019933]; cell surface receptor signaling pathway [GO:0007166]; ear development [GO:0043583]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; mitochondrion organization [GO:0007005]; myelination [GO:0042552]; myelination in peripheral nervous system [GO:0022011]; myelination of posterior lateral line nerve axons [GO:0048932]; ossification [GO:0001503]; peripheral nervous system myelin formation [GO:0032290]; regulation of sprouting angiogenesis [GO:1903670]; semicircular canal fusion [GO:0060879] GO:0001503; GO:0004930; GO:0005518; GO:0005622; GO:0005886; GO:0007005; GO:0007166; GO:0007186; GO:0007507; GO:0016021; GO:0019933; GO:0022011; GO:0032290; GO:0042552; GO:0043583; GO:0048932; GO:0050840; GO:0060347; GO:0060879; GO:1903670 0 0 0 PF00002;PF00431;PF01825;PF00354; E5RJM6 CHOYP_LOC100371435.1.1 m.6503 sp ANR65_HUMAN 39.048 105 63 1 14 118 47 150 5.28E-13 70.5 ANR65_HUMAN reviewed Ankyrin repeat domain-containing protein 65 ANKRD65 Homo sapiens (Human) 399 0 0 0 0 0 PF12796; G3V9R8 CHOYP_BRAFLDRAFT_126700.1.2 m.17811 sp HNRPC_RAT 58.14 86 34 1 55 138 4 89 5.28E-27 110 HNRPC_RAT reviewed Heterogeneous nuclear ribonucleoprotein C (hnRNP C) (hnRNP core protein C) Hnrnpc Hnrpc Rattus norvegicus (Rat) 298 "mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA modification [GO:0090367]" GO:0000166; GO:0000398; GO:0003729; GO:0004857; GO:0005634; GO:0005681; GO:0019904; GO:0043021; GO:0090367; GO:1990247; GO:1990826; GO:1990827 0 0 0 PF00076; O35601 CHOYP_CD36_40650.1.1 m.47015 sp FYB_MOUSE 43.529 85 42 2 640 724 509 587 5.28E-11 69.7 FYB_MOUSE reviewed FYN-binding protein (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein) Fyb Mus musculus (Mouse) 819 immune response [GO:0006955]; protein localization to plasma membrane [GO:0072659]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852] GO:0005102; GO:0005634; GO:0005829; GO:0005886; GO:0006955; GO:0007165; GO:0015629; GO:0030054; GO:0050852; GO:0072659 0 0 0 PF14603;PF07653; O70277 CHOYP_contig_040705 m.46262 sp TRIM3_RAT 25.49 153 108 3 41 189 593 743 5.28E-09 59.3 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P02594 CHOYP_CALM.5.50 m.9467 sp CALM_ELEEL 60.465 86 32 1 14 99 64 147 5.28E-29 104 CALM_ELEEL reviewed Calmodulin (CaM) calm Electrophorus electricus (Electric eel) (Gymnotus electricus) 149 0 GO:0005509 0 0 0 PF13499; P20241 CHOYP_LOC100863781.1.1 m.33751 sp NRG_DROME 29.283 1284 780 43 26 1257 28 1235 5.28E-133 443 NRG_DROME reviewed Neuroglian Nrg CG1634 Drosophila melanogaster (Fruit fly) 1302 "axon ensheathment [GO:0008366]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; cell adhesion involved in heart morphogenesis [GO:0061343]; central complex development [GO:0048036]; dendrite morphogenesis [GO:0048813]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of glial blood-brain barrier [GO:0060857]; female courtship behavior [GO:0008050]; imaginal disc morphogenesis [GO:0007560]; male courtship behavior [GO:0008049]; melanotic encapsulation of foreign target [GO:0035011]; motor neuron axon guidance [GO:0008045]; mushroom body development [GO:0016319]; nerve maturation [GO:0021682]; neuron cell-cell adhesion [GO:0007158]; neuron projection morphogenesis [GO:0048812]; photoreceptor cell axon guidance [GO:0072499]; regulation of female receptivity [GO:0045924]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]; synapse organization [GO:0050808]" GO:0005509; GO:0005886; GO:0005918; GO:0005919; GO:0005923; GO:0007158; GO:0007173; GO:0007409; GO:0007560; GO:0008045; GO:0008049; GO:0008050; GO:0008366; GO:0016021; GO:0016319; GO:0016328; GO:0019991; GO:0021682; GO:0030175; GO:0035011; GO:0035151; GO:0045924; GO:0048036; GO:0048675; GO:0048812; GO:0048813; GO:0050808; GO:0060857; GO:0061343; GO:0072499 0 0 0 PF13882;PF00041;PF07679;PF00047; P90703 CHOYP_LOC100175959.6.7 m.50301 sp RLA2_BRUMA 44.037 109 60 1 11 118 5 113 5.28E-24 92 RLA2_BRUMA reviewed 60S acidic ribosomal protein P2 rpp-2 Brugia malayi (Filarial nematode worm) 114 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 Q0DXS3 CHOYP_BRAFLDRAFT_99723.9.9 m.61616 sp RDR1_ORYSJ 38.472 733 403 16 368 1072 7 719 5.28E-138 450 RDR1_ORYSJ reviewed Probable RNA-dependent RNA polymerase 1 (OsRDR1) (EC 2.7.7.48) RDR1 Os02g0736200 LOC_Os02g50330 Oryza sativa subsp. japonica (Rice) 740 gene silencing by RNA [GO:0031047] GO:0003723; GO:0003968; GO:0031047 0 0 0 PF05183; Q12955 CHOYP_LOC581491.2.2 m.58871 sp ANK3_HUMAN 27.922 616 390 10 93 700 87 656 5.28E-55 217 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q4UMH6 CHOYP_LOC100889142.4.4 m.54326 sp Y381_RICFE 26.708 322 214 9 64 381 830 1133 5.28E-23 105 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5ZIJ9 CHOYP_LOC100374277.3.3 m.45767 sp MIB2_CHICK 63.066 287 96 4 1 284 9 288 5.28E-118 370 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q8C525 CHOYP_AAEL_AAEL009477.1.1 m.62537 sp M21D2_MOUSE 29.67 182 120 6 246 424 178 354 5.28E-13 75.5 M21D2_MOUSE reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) Mb21d2 Mus musculus (Mouse) 428 0 GO:0032403 0 0 0 PF03281; Q8R4I7 CHOYP_NETO1.1.1 m.10276 sp NETO1_MOUSE 30.4 375 224 8 8 373 3 349 5.28E-48 179 NETO1_MOUSE reviewed Neuropilin and tolloid-like protein 1 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1) Neto1 Btcl1 Mus musculus (Mouse) 533 memory [GO:0007613]; positive regulation of excitatory postsynaptic potential [GO:2000463]; receptor localization to synapse [GO:0097120]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; visual learning [GO:0008542] GO:0007613; GO:0008542; GO:0014069; GO:0016021; GO:0030054; GO:0035255; GO:0045202; GO:0045211; GO:0048169; GO:0060076; GO:0097120; GO:2000463 0 0 0 PF00431;PF00057; Q9H2L4 CHOYP_BRAFLDRAFT_125975.1.1 m.25933 sp TMM60_HUMAN 35.433 127 79 2 1 125 3 128 5.28E-21 85.1 TMM60_HUMAN reviewed Transmembrane protein 60 TMEM60 C7orf35 DC32 Homo sapiens (Human) 133 0 GO:0016021 0 0 0 PF10269; A4IF63 CHOYP_BRAFLDRAFT_69765.9.23 m.32956 sp TRIM2_BOVIN 23.529 153 115 1 321 473 593 743 5.29E-07 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8MU46 CHOYP_LOC756222.1.2 m.62 sp SMTL1_HUMAN 55.629 151 61 2 163 311 300 446 5.29E-53 183 SMTL1_HUMAN reviewed Smoothelin-like protein 1 SMTNL1 Homo sapiens (Human) 457 negative regulation of vasodilation [GO:0045908]; positive regulation of vasoconstriction [GO:0045907] GO:0005634; GO:0005737; GO:0031430; GO:0031674; GO:0043292; GO:0045907; GO:0045908 0 0 0 PF00307; B3EWY9 CHOYP_contig_024234 m.27518 sp MLP_ACRMI 28.918 1072 604 46 59 1066 388 1365 5.29E-97 350 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O43301 CHOYP_BRAFLDRAFT_208436.11.32 m.42955 sp HS12A_HUMAN 36.916 214 124 7 929 1135 36 245 5.29E-30 131 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P16157 CHOYP_LOC753709.43.44 m.64126 sp ANK1_HUMAN 31.593 728 442 23 18 724 84 776 5.29E-63 233 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P42566 CHOYP_LOC100708054.1.1 m.57813 sp EPS15_HUMAN 32.086 187 121 2 21 207 131 311 5.29E-26 120 EPS15_HUMAN reviewed Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) EPS15 AF1P Homo sapiens (Human) 896 cell proliferation [GO:0008283]; clathrin coat assembly [GO:0048268]; endocytic recycling [GO:0032456]; epidermal growth factor receptor signaling pathway [GO:0007173]; Golgi to endosome transport [GO:0006895]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; protein transport [GO:0015031]; receptor-mediated endocytosis of virus by host cell [GO:0019065]; vesicle organization [GO:0016050]; viral entry into host cell [GO:0046718] GO:0005509; GO:0005737; GO:0005829; GO:0005886; GO:0005905; GO:0005913; GO:0006895; GO:0007173; GO:0008283; GO:0015031; GO:0016020; GO:0016050; GO:0016235; GO:0019065; GO:0030122; GO:0031593; GO:0031901; GO:0032456; GO:0042059; GO:0043231; GO:0046718; GO:0048268; GO:0060170; GO:0098641 0 0 0 PF12763; Q05941 CHOYP_ACH1.1.1 m.58842 sp ACHA7_RAT 34.754 305 187 6 41 340 36 333 5.29E-52 185 ACHA7_RAT reviewed Neuronal acetylcholine receptor subunit alpha-7 Chrna7 Acra7 Rattus norvegicus (Rat) 502 "calcium ion transport [GO:0006816]; dopamine biosynthetic process [GO:0042416]; neuronal action potential [GO:0019228]; regulation of membrane potential [GO:0042391]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0007165; GO:0007271; GO:0008144; GO:0008179; GO:0014069; GO:0019228; GO:0019901; GO:0030054; GO:0030424; GO:0030425; GO:0030426; GO:0032279; GO:0042166; GO:0042391; GO:0042416; GO:0042734; GO:0043025; GO:0043197; GO:0043198; GO:0045121; GO:0045211; GO:0051117; GO:0097110 0 0 0 PF02931;PF02932; Q6A070 CHOYP_FAM179B.1.2 m.10735 sp F179B_MOUSE 34.902 871 472 18 807 1651 968 1769 5.29E-128 444 F179B_MOUSE reviewed Protein FAM179B Fam179b Kiaa0423 Mus musculus (Mouse) 1776 0 0 0 0 0 0 Q6R7G0 CHOYP_YG31B.3.3 m.27446 sp Y068_OSHVF 22.787 610 402 12 27 568 23 631 5.29E-45 176 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6TLH3 CHOYP_CUEDC2.1.1 m.3490 sp CUED2_DANRE 39.858 281 164 3 9 288 6 282 5.29E-59 192 CUED2_DANRE reviewed CUE domain-containing protein 2 cuedc2 zgc:92255 Danio rerio (Zebrafish) (Brachydanio rerio) 282 0 GO:0005634; GO:0005737 0 0 0 0 Q8C0L6 CHOYP_BRAFLDRAFT_125091.1.1 m.9429 sp PAOX_MOUSE 30.321 498 313 12 19 495 6 490 5.29E-59 206 PAOX_MOUSE reviewed Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase) Paox Pao Mus musculus (Mouse) 504 polyamine catabolic process [GO:0006598]; positive regulation of spermidine biosynthetic process [GO:1901307]; putrescine biosynthetic process [GO:0009446]; putrescine catabolic process [GO:0009447]; spermidine catabolic process [GO:0046203]; spermine catabolic process [GO:0046208] GO:0005102; GO:0005782; GO:0006598; GO:0009446; GO:0009447; GO:0046203; GO:0046208; GO:0046592; GO:0052899; GO:0052901; GO:0052902; GO:0052903; GO:0052904; GO:1901307 PATHWAY: Amine and polyamine metabolism; spermine metabolism. 0 0 PF01593; Q8CFY5 CHOYP_LOC100695060.1.1 m.7580 sp COX10_MOUSE 59.567 277 112 0 138 414 135 411 5.29E-111 337 COX10_MOUSE reviewed "Protoheme IX farnesyltransferase, mitochondrial (EC 2.5.1.-) (Heme O synthase)" Cox10 Mus musculus (Mouse) 443 aerobic respiration [GO:0009060]; cellular respiration [GO:0045333]; cytochrome complex assembly [GO:0017004]; heme a biosynthetic process [GO:0006784]; heme O biosynthetic process [GO:0048034]; mitochondrial fission [GO:0000266]; mitochondrion organization [GO:0007005]; protein farnesylation [GO:0018343]; respiratory chain complex IV assembly [GO:0008535] GO:0000266; GO:0004129; GO:0004311; GO:0005739; GO:0006784; GO:0007005; GO:0008495; GO:0008535; GO:0009060; GO:0016021; GO:0017004; GO:0018343; GO:0031966; GO:0045333; GO:0048034; GO:0070069 0 0 cd13957; PF01040; Q90W98 CHOYP_IVBI.2.2 m.67049 sp VKT4_PSETT 56.863 51 22 0 56 106 31 81 5.29E-14 66.2 VKT4_PSETT reviewed Kunitz-type serine protease inhibitor textilinin-4 (Txln-4) 0 Pseudonaja textilis textilis (Eastern brown snake) 83 0 GO:0004867; GO:0005576 0 0 0 PF00014; Q96GP6 CHOYP_LOC579946.8.24 m.40378 sp SREC2_HUMAN 40.606 165 89 6 179 343 278 433 5.29E-25 109 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q99NH0 CHOYP_LOC754035.3.6 m.41298 sp ANR17_MOUSE 37.941 340 184 12 299 623 231 558 5.29E-49 188 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9DBU6 CHOYP_contig_046832 m.55023 sp RSRC1_MOUSE 29.187 209 129 4 106 296 123 330 5.29E-06 50.8 RSRC1_MOUSE reviewed Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1) Rsrc1 Srrp53 Mus musculus (Mouse) 334 "alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]; nucleocytoplasmic transport [GO:0006913]; protein phosphorylation [GO:0006468]; response to antibiotic [GO:0046677]; RNA splicing [GO:0008380]" GO:0000380; GO:0000398; GO:0005634; GO:0005737; GO:0006468; GO:0006913; GO:0008380; GO:0016607; GO:0046677 0 0 0 0 Q9GZZ6 CHOYP_ACHAA.2.2 m.62698 sp ACH10_HUMAN 26.34 429 279 10 198 604 34 447 5.29E-38 149 ACH10_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 NACHRA10 Homo sapiens (Human) 450 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell proliferation [GO:0042127]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005102; GO:0005262; GO:0005892; GO:0007165; GO:0007204; GO:0007271; GO:0016020; GO:0030054; GO:0030424; GO:0042127; GO:0042166; GO:0042472; GO:0043204; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; Q9HC78 CHOYP_ZBT20.1.1 m.10389 sp ZBT20_HUMAN 31.111 135 85 4 545 679 555 681 5.29E-12 72.8 ZBT20_HUMAN reviewed Zinc finger and BTB domain-containing protein 20 (Dendritic-derived BTB/POZ zinc finger protein) (Zinc finger protein 288) ZBTB20 DPZF ZNF288 Homo sapiens (Human) 741 "positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of tumor necrosis factor production [GO:0032760]; transcription, DNA-templated [GO:0006351]" GO:0001078; GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0032728; GO:0032755; GO:0032760; GO:0046872 0 0 0 PF00651;PF00096; Q9Z254 CHOYP_GIPC1.1.1 m.60630 sp GIPC1_RAT 56.637 339 129 7 5 336 5 332 5.29E-126 367 GIPC1_RAT reviewed PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (GLUT1 C-terminal-binding protein) (GLUT1CBP) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) Gipc1 Gipc Rgs19ip1 Rattus norvegicus (Rat) 333 chemical synaptic transmission [GO:0007268]; endothelial cell migration [GO:0043542]; glutamate secretion [GO:0014047]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cytokinesis [GO:0032467]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein targeting [GO:0006605]; regulation of protein stability [GO:0031647]; regulation of synaptic plasticity [GO:0048167] GO:0005829; GO:0005903; GO:0005938; GO:0006605; GO:0007268; GO:0008021; GO:0012506; GO:0014047; GO:0016020; GO:0030139; GO:0030165; GO:0030511; GO:0031647; GO:0032435; GO:0032467; GO:0043197; GO:0043198; GO:0043542; GO:0048167; GO:0070062 0 0 0 PF00595; A4IF63 CHOYP_BRAFLDRAFT_87285.7.8 m.60157 sp TRIM2_BOVIN 24.648 142 104 2 375 513 602 743 5.30E-07 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O89110 CHOYP_CASP8.1.1 m.54330 sp CASP8_MOUSE 34.454 238 122 4 155 375 213 433 5.30E-36 140 CASP8_MOUSE reviewed Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Mus musculus (Mouse) 480 activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cardiac muscle tissue development [GO:0048738]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; heart development [GO:0007507]; hepatocyte apoptotic process [GO:0097284]; macrophage differentiation [GO:0030225]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of necroptotic process [GO:0060546]; neural tube formation [GO:0001841]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of apoptotic signaling pathway [GO:2001233]; regulation of thymocyte apoptotic process [GO:0070243]; response to tumor necrosis factor [GO:0034612]; TRAIL-activated apoptotic signaling pathway [GO:0036462] GO:0001525; GO:0001841; GO:0004175; GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005815; GO:0005829; GO:0005886; GO:0006508; GO:0006915; GO:0006919; GO:0007507; GO:0008233; GO:0008625; GO:0030225; GO:0030690; GO:0031264; GO:0031265; GO:0031625; GO:0034612; GO:0035877; GO:0036462; GO:0042802; GO:0043123; GO:0043124; GO:0045651; GO:0045862; GO:0046982; GO:0048738; GO:0051603; GO:0060546; GO:0070243; GO:0097110; GO:0097153; GO:0097190; GO:0097191; GO:0097194; GO:0097199; GO:0097202; GO:0097284; GO:0097342; GO:2001233; GO:2001238 0 0 0 PF01335; O94813 CHOYP_BRAFLDRAFT_85165.1.1 m.48977 sp SLIT2_HUMAN 26.19 210 147 4 7 214 11 214 5.30E-13 73.6 SLIT2_HUMAN reviewed Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) 1529 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; response to cortisol [GO:0051414]; response to nutrient levels [GO:0031667]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510]; ureteric bud development [GO:0001657] GO:0001657; GO:0001933; GO:0002042; GO:0002689; GO:0005095; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005737; GO:0005886; GO:0007411; GO:0008045; GO:0008201; GO:0009986; GO:0010593; GO:0010596; GO:0014912; GO:0016020; GO:0021510; GO:0021836; GO:0021972; GO:0030308; GO:0030336; GO:0030837; GO:0031290; GO:0031667; GO:0032870; GO:0035385; GO:0042802; GO:0042803; GO:0043065; GO:0043116; GO:0043237; GO:0043394; GO:0043395; GO:0048495; GO:0048754; GO:0048846; GO:0050728; GO:0050772; GO:0050919; GO:0050929; GO:0051058; GO:0051414; GO:0061364; GO:0070062; GO:0070100; GO:0071504; GO:0071672; GO:0071676; GO:0090024; GO:0090027; GO:0090260; GO:0090288 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P0DKY8 CHOYP_NUD16.1.2 m.10250 sp NUD16_HOMVI 50.556 180 88 1 3 182 7 185 5.30E-57 182 NUD16_HOMVI reviewed U8 snoRNA-decapping enzyme (EC 3.6.1.62) (IDP phosphatase) (IDPase) (EC 3.6.1.64) (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (m7GpppN-mRNA hydrolase) NUDT16 Homalodisca vitripennis (Glassy-winged sharpshooter) (Homalodisca coagulata) 187 nucleotide metabolic process [GO:0009117] GO:0000166; GO:0003723; GO:0005654; GO:0005730; GO:0005737; GO:0009117; GO:0016787; GO:0046872 0 0 0 PF00293; P27401 CHOYP_LOC100708199.4.6 m.33491 sp POL_SFV3L 25.926 135 97 2 1 134 835 967 5.30E-13 67.8 POL_SFV3L reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Simian foamy virus type 3 (strain LK3) (SFVagm) (SFV-3) 1143 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; Q14978 CHOYP_LOC100658481.1.1 m.8712 sp NOLC1_HUMAN 59.292 113 40 2 772 879 588 699 5.30E-32 137 NOLC1_HUMAN reviewed Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) NOLC1 KIAA0035 NS5ATP13 Homo sapiens (Human) 699 cell cycle [GO:0007049]; mitotic nuclear division [GO:0007067]; nucleolus organization [GO:0007000]; rRNA processing [GO:0006364] GO:0005524; GO:0005525; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0007000; GO:0007049; GO:0007067; GO:0015030; GO:0044822 0 0 0 PF05022; Q29S00 CHOYP_OSCP1.1.1 m.36557 sp OSCP1_BOVIN 50.935 214 89 8 1 203 169 377 5.30E-57 187 OSCP1_BOVIN reviewed Protein OSCP1 OSCP1 Bos taurus (Bovine) 379 positive regulation of protein targeting to mitochondrion [GO:1903955]; transport [GO:0006810] GO:0006810; GO:0009925; GO:1903955 0 0 0 PF10188; Q3ZBT2 CHOYP_FBX9.1.1 m.49865 sp FBX9_BOVIN 41.446 415 220 7 54 448 26 437 5.30E-104 319 FBX9_BOVIN reviewed F-box only protein 9 FBXO9 Bos taurus (Bovine) 437 fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; protein ubiquitination [GO:0016567]; regulation of TOR signaling [GO:0032006]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0016567; GO:0019005; GO:0031146; GO:0032006; GO:0045087; GO:0045444 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; Q5D0E6 CHOYP_BRAFLDRAFT_103698.1.1 m.19261 sp DALD3_HUMAN 29.505 566 325 17 45 587 29 543 5.30E-61 214 DALD3_HUMAN reviewed DALR anticodon-binding domain-containing protein 3 DALRD3 Homo sapiens (Human) 543 arginyl-tRNA aminoacylation [GO:0006420] GO:0004814; GO:0005524; GO:0006420 0 0 0 PF05746; Q5REG4 CHOYP_DTX3.1.3 m.54387 sp DTX3_PONAB 61.268 142 53 2 1 140 205 346 5.30E-52 171 DTX3_PONAB reviewed Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 347 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] GO:0005737; GO:0007219; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q5ZJ75 CHOYP_CPIPJ_CPIJ001137.1.2 m.7136 sp SL9A8_CHICK 52.846 246 109 3 85 327 44 285 5.30E-79 254 SL9A8_CHICK reviewed Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8) 0 Gallus gallus (Chicken) 574 regulation of pH [GO:0006885] GO:0000139; GO:0006885; GO:0015385; GO:0016021 0 0 0 PF00999; Q640E9 CHOYP_WIBG.1.1 m.11521 sp PYM1_XENLA 49.733 187 83 3 33 208 13 199 5.30E-45 151 PYM1_XENLA reviewed Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) pym1 pym wibg Xenopus laevis (African clawed frog) 199 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of translation [GO:0045727]" GO:0000184; GO:0005654; GO:0005730; GO:0005737; GO:0035145; GO:0043022; GO:0045727 0 0 0 PF09282; Q6P9N1 CHOYP_PHUM_PHUM176650.1.1 m.13332 sp HYCCI_MOUSE 32.981 473 271 11 6 471 8 441 5.30E-71 238 HYCCI_MOUSE reviewed Hyccin (Down-regulated by CTNNB1 protein A) (Protein FAM126A) Fam126a Drctnnb1a Mus musculus (Mouse) 521 establishment of protein localization to plasma membrane [GO:0090002]; myelination [GO:0042552]; phosphatidylinositol phosphorylation [GO:0046854] GO:0005737; GO:0005829; GO:0005886; GO:0042552; GO:0043005; GO:0046854; GO:0090002 0 0 0 PF09790; Q8CFV9 CHOYP_LOC101072503.1.1 m.54785 sp RIFK_MOUSE 59.836 122 49 0 437 558 29 150 5.30E-46 162 RIFK_MOUSE reviewed Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase) (KOI-4) Rfk Mus musculus (Mouse) 155 apoptotic process [GO:0006915]; FMN biosynthetic process [GO:0009398]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; reactive oxygen species metabolic process [GO:0072593]; riboflavin biosynthetic process [GO:0009231] GO:0005524; GO:0005739; GO:0006915; GO:0008531; GO:0009231; GO:0009398; GO:0033864; GO:0046872; GO:0072593 PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. 0 0 PF01687; Q8RA32 CHOYP_LOC100570366.2.3 m.60724 sp DPO3_CALS4 30.435 184 101 8 434 611 385 547 5.30E-09 63.5 DPO3_CALS4 reviewed DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC TTE1398 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis) 1401 DNA-dependent DNA replication [GO:0006261] GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 0 0 0 PF11490;PF07733;PF14579;PF02811;PF00929; Q9ES28 CHOYP_ARHG7.2.5 m.23155 sp ARHG7_MOUSE 48.235 85 40 2 23 103 776 860 5.30E-17 78.2 ARHG7_MOUSE reviewed Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR) Arhgef7 Kiaa0142 Pak3bp Mus musculus (Mouse) 862 focal adhesion assembly [GO:0048041]; Golgi organization [GO:0007030]; hematopoietic progenitor cell differentiation [GO:0002244]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of growth hormone secretion [GO:0060124]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of protein binding [GO:0032092]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of GTP binding [GO:1904424]; regulation of Rho protein signal transduction [GO:0035023] GO:0000322; GO:0001726; GO:0002244; GO:0005085; GO:0005089; GO:0005829; GO:0005886; GO:0005925; GO:0005938; GO:0007030; GO:0007399; GO:0010763; GO:0019901; GO:0030027; GO:0030032; GO:0032092; GO:0035023; GO:0035556; GO:0043005; GO:0043025; GO:0043065; GO:0043234; GO:0043547; GO:0048041; GO:0060124; GO:1900026; GO:1904424; GO:2000394 0 0 0 PF16523;PF00307;PF00169;PF00621;PF07653; Q9NQR1 CHOYP_LOC100892236.6.7 m.55463 sp KMT5A_HUMAN 37.324 142 80 5 31 168 257 393 5.30E-16 84.7 KMT5A_HUMAN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A PRSET7 SET07 SET8 SETD8 Homo sapiens (Human) 393 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0003714; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006351; GO:0007067; GO:0016278; GO:0016279; GO:0018024; GO:0018026; GO:0042799; GO:0043516; GO:0045892; GO:0051301; GO:1901796 0 0 0 PF00856; B2IZD3 CHOYP_BRAFLDRAFT_89869.2.3 m.37104 sp BDLP_NOSP7 25.833 120 82 1 137 249 72 191 5.31E-08 60.1 BDLP_NOSP7 reviewed Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5) Npun_R6513 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 693 0 GO:0003924; GO:0005525; GO:0005886; GO:0008289; GO:0016021 0 0 0 PF00350; B9EKR1 CHOYP_PTPRZ1.1.1 m.24190 sp PRPTZ_MOUSE 38.732 284 148 8 1 267 1790 2064 5.31E-50 180 PRPTZ_MOUSE reviewed Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) Ptprz1 Mus musculus (Mouse) 2312 axonal fasciculation [GO:0007413]; axonogenesis [GO:0007409]; hematopoietic progenitor cell differentiation [GO:0002244]; hippocampus development [GO:0021766]; learning or memory [GO:0007611]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of dendrite development [GO:2000171]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of dendrite development [GO:1900006]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron migration [GO:2001224]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of Schwann cell migration [GO:1900149]; regulation of dendrite morphogenesis [GO:0048814]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]; visual learning [GO:0008542] GO:0002244; GO:0004725; GO:0005578; GO:0005615; GO:0005737; GO:0007409; GO:0007413; GO:0007611; GO:0008285; GO:0008542; GO:0010812; GO:0016021; GO:0021766; GO:0030027; GO:0030175; GO:0030424; GO:0030426; GO:0031226; GO:0032587; GO:0035335; GO:0043025; GO:0043197; GO:0045211; GO:0048146; GO:0048709; GO:0048814; GO:0050731; GO:0070445; GO:0072534; GO:1900006; GO:1900149; GO:1901216; GO:2000171; GO:2001224 0 0 0 PF00194;PF00041;PF00102; O75179 CHOYP_LOC754728.6.6 m.46535 sp ANR17_HUMAN 40.11 182 100 6 7 182 535 713 5.31E-23 98.6 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P23034 CHOYP_LOC582121.1.1 m.30176 sp AAT_BACY2 28.753 393 248 15 16 396 1 373 5.31E-45 164 AAT_BACY2 reviewed Aspartate aminotransferase (AspAT) (EC 2.6.1.1) (Transaminase A) 0 Bacillus sp. (strain YM-2) 392 biosynthetic process [GO:0009058] GO:0004069; GO:0005737; GO:0009058; GO:0030170; GO:0080130 0 0 0 PF00155; P37064 CHOYP_LOC100206475.13.16 m.54375 sp ASO_CUCPM 26.059 614 323 21 85 661 24 543 5.31E-45 172 ASO_CUCPM reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) 0 Cucurbita pepo var. melopepo (Zucchini) 552 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P42930 CHOYP_SMP_049250.1.1 m.1835 sp HSPB1_RAT 32.71 107 70 2 15 119 67 173 5.31E-08 55.1 HSPB1_RAT reviewed Heat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) Hspb1 Hsp27 Rattus norvegicus (Rat) 206 aging [GO:0007568]; cellular response to butyrate [GO:1903545]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to interleukin-11 [GO:0071348]; female pregnancy [GO:0007565]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced cell death [GO:1903202]; positive regulation of neuron projection development [GO:0010976]; response to angiotensin [GO:1990776]; response to ischemia [GO:0002931]; response to muscle stretch [GO:0035994] GO:0000502; GO:0002931; GO:0005634; GO:0005737; GO:0005819; GO:0005886; GO:0007565; GO:0007568; GO:0010976; GO:0030424; GO:0030425; GO:0031430; GO:0031674; GO:0035994; GO:0043066; GO:0043130; GO:0043204; GO:0045202; GO:0070301; GO:0071348; GO:0097512; GO:0098839; GO:1903202; GO:1903545; GO:1990776 0 0 0 PF00011; Q6PFY8 CHOYP_BRAFLDRAFT_88224.1.11 m.657 sp TRI45_MOUSE 24.542 273 185 12 4 261 127 393 5.31E-09 62.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8IVN8 CHOYP_NEMVEDRAFT_V1G226328.1.1 m.11691 sp SBSPO_HUMAN 32.955 264 152 9 29 288 22 264 5.31E-35 130 SBSPO_HUMAN reviewed Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) SBSPON C8orf84 RPESP Homo sapiens (Human) 264 immune response [GO:0006955] GO:0005044; GO:0005578; GO:0006955; GO:0030247 0 0 0 PF00090; Q8K0U4 CHOYP_LOC591177.1.1 m.1476 sp HS12A_MOUSE 34.253 616 340 16 118 678 56 661 5.31E-102 329 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K3K9 CHOYP_LOC100149190.1.1 m.22100 sp GIMA4_RAT 29.73 222 132 5 207 410 22 237 5.31E-23 102 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q99NH0 CHOYP_LOC100889142.3.4 m.42346 sp ANR17_MOUSE 44.737 114 59 3 7 118 534 645 5.31E-18 81.6 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9EQJ4 CHOYP_ZN394.1.1 m.48613 sp ZN384_RAT 21.667 180 104 5 159 328 305 457 5.31E-07 55.1 ZN384_RAT reviewed Zinc finger protein 384 (Cas-associated zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) Znf384 Ciz Nmp4 Zfp384 Rattus norvegicus (Rat) 579 "nucleocytoplasmic transport [GO:0006913]; positive regulation of protein secretion [GO:0050714]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005925; GO:0006351; GO:0006913; GO:0017124; GO:0043565; GO:0045944; GO:0046872; GO:0050714 0 0 0 PF00096;PF13912; Q9I8C7 CHOYP_NEMVEDRAFT_V1G205855.1.2 m.26367 sp ACH10_CHICK 32.42 219 143 2 32 245 17 235 5.31E-33 127 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9QUK6 CHOYP_TLR4.1.4 m.20703 sp TLR4_MOUSE 36.296 135 69 6 7 128 672 802 5.31E-12 70.1 TLR4_MOUSE reviewed Toll-like receptor 4 (CD antigen CD284) Tlr4 Lps Mus musculus (Mouse) 835 activation of innate immune response [GO:0002218]; activation of MAPK activity [GO:0000187]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; astrocyte development [GO:0014002]; B cell proliferation involved in immune response [GO:0002322]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to mechanical stimulus [GO:0071260]; defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; I-kappaB phosphorylation [GO:0007252]; innate immune response [GO:0045087]; interferon-gamma production [GO:0032609]; interleukin-1 beta secretion [GO:0050702]; intestinal epithelial structure maintenance [GO:0060729]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation [GO:0042116]; mast cell activation [GO:0045576]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide production involved in inflammatory response [GO:0002537]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine production [GO:0032722]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 biosynthetic process [GO:0045084]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 biosynthetic process [GO:0045368]; positive regulation of interleukin-1 biosynthetic process [GO:0045362]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 biosynthetic process [GO:0045416]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of platelet activation [GO:0010572]; positive regulation of stress-activated MAPK cascade [GO:0032874]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cytokine secretion [GO:0050707]; regulation of dendritic cell cytokine production [GO:0002730]; regulation of inflammatory response [GO:0050727]; response to bacterium [GO:0009617]; response to lipopolysaccharide [GO:0032496]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0000187; GO:0001530; GO:0001875; GO:0002218; GO:0002224; GO:0002322; GO:0002537; GO:0002730; GO:0002755; GO:0004888; GO:0005737; GO:0005886; GO:0005887; GO:0007250; GO:0007252; GO:0009617; GO:0009897; GO:0009986; GO:0010572; GO:0010628; GO:0014002; GO:0030890; GO:0031226; GO:0031663; GO:0032496; GO:0032497; GO:0032609; GO:0032689; GO:0032700; GO:0032707; GO:0032715; GO:0032720; GO:0032722; GO:0032727; GO:0032728; GO:0032729; GO:0032732; GO:0032733; GO:0032735; GO:0032755; GO:0032757; GO:0032760; GO:0032874; GO:0034142; GO:0042116; GO:0042346; GO:0042535; GO:0043123; GO:0045084; GO:0045087; GO:0045348; GO:0045359; GO:0045362; GO:0045368; GO:0045410; GO:0045416; GO:0045429; GO:0045576; GO:0045944; GO:0046330; GO:0046696; GO:0048471; GO:0050671; GO:0050702; GO:0050707; GO:0050727; GO:0050829; GO:0051092; GO:0051770; GO:0060729; GO:0060907; GO:0070373; GO:0070374; GO:0070430; GO:0070434; GO:0071222; GO:0071223; GO:0071260; GO:1900227 0 0 0 PF00560;PF13855;PF01582; Q9QXM0 CHOYP_ABHD2.1.2 m.24824 sp ABHD2_MOUSE 46.419 377 198 2 17 390 29 404 5.31E-121 360 ABHD2_MOUSE reviewed Monoacylglycerol lipase ABHD2 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 2) (Lung alpha/beta hydrolase 2) (MmLABH2) Abhd2 Labh-2 Labh2 Mus musculus (Mouse) 425 acrosome reaction [GO:0007340]; acylglycerol catabolic process [GO:0046464]; negative regulation of cell migration [GO:0030336]; response to progesterone [GO:0032570]; response to wounding [GO:0009611]; sperm capacitation [GO:0048240]; steroid hormone mediated signaling pathway [GO:0043401] GO:0001669; GO:0002080; GO:0003707; GO:0007340; GO:0009611; GO:0016021; GO:0030336; GO:0032570; GO:0036126; GO:0042562; GO:0043401; GO:0046464; GO:0047372; GO:0048240; GO:0097524 0 0 0 PF00561; Q9UPS8 CHOYP_ANR26.1.1 m.57187 sp ANR26_HUMAN 26.401 1106 606 24 1130 2139 716 1709 5.31E-68 259 ANR26_HUMAN reviewed Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) 1709 0 GO:0005813 0 0 0 PF00023;PF12796;PF12001; Q9V5N8 CHOYP_BRAFLDRAFT_208436.4.32 m.22688 sp STAN_DROME 31.472 197 125 3 1 187 925 1121 5.31E-21 96.7 STAN_DROME reviewed Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) 3579 "axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Wnt signaling pathway [GO:0030178]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; positive regulation of Wnt signaling pathway [GO:0030177]; R3/R4 cell fate commitment [GO:0007464]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of establishment of planar polarity [GO:0090175]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" GO:0001736; GO:0001738; GO:0004872; GO:0004888; GO:0004930; GO:0005057; GO:0005509; GO:0005887; GO:0005911; GO:0007156; GO:0007164; GO:0007165; GO:0007367; GO:0007409; GO:0007411; GO:0007464; GO:0016021; GO:0016055; GO:0016318; GO:0016319; GO:0016339; GO:0016358; GO:0019233; GO:0030177; GO:0030178; GO:0035159; GO:0042067; GO:0045746; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:0090175; GO:1902669 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9VAC5 CHOYP_LOC100645870.1.1 m.63229 sp ADA17_DROME 35.753 744 417 23 22 746 29 730 5.31E-140 432 ADA17_DROME reviewed ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) 732 membrane protein ectodomain proteolysis [GO:0006509] GO:0004222; GO:0006509; GO:0008270; GO:0016021 0 0 0 PF16698;PF00200;PF01562; O46160 CHOYP_RL14.1.9 m.3289 sp RL14_LUMRU 63.121 141 52 0 3 143 1 141 5.32E-60 185 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; O60290 CHOYP_LOC100495689.1.1 m.33609 sp ZN862_HUMAN 25.316 316 215 6 10 317 559 861 5.32E-21 97.8 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; P07207 CHOYP_NOTCH.1.6 m.3445 sp NOTCH_DROME 27.357 541 280 22 535 1022 528 1008 5.32E-21 105 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P13908 CHOYP_LOC446015.1.1 m.10760 sp ACHN2_CARAU 25.815 399 272 8 27 403 34 430 5.32E-42 157 ACHN2_CARAU reviewed Neuronal acetylcholine receptor subunit non-alpha-2 (GFN-alpha-2) 0 Carassius auratus (Goldfish) 462 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; Q24157 CHOYP_LOC100376635.1.1 m.9789 sp BRN_DROME 32.342 269 152 8 90 340 60 316 5.32E-35 133 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q24K15 CHOYP_LOC100639584.3.3 m.22934 sp ANGP4_BOVIN 42.523 214 116 4 105 314 285 495 5.32E-54 186 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q28623 CHOYP_SLMAP.3.8 m.19179 sp SLMAP_RABIT 60.471 382 141 4 16 390 3 381 5.32E-148 459 SLMAP_RABIT reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP SLAP Oryctolagus cuniculus (Rabbit) 771 muscle contraction [GO:0006936] GO:0005615; GO:0005737; GO:0005815; GO:0006936; GO:0016021; GO:0042383 0 0 0 PF00498; Q6PFY8 CHOYP_LOC100378898.4.10 m.43264 sp TRI45_MOUSE 28.302 212 119 6 8 205 129 321 5.32E-12 72 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6TH47 CHOYP_FA13A.1.2 m.297 sp STBPA_DANRE 57.286 199 79 3 29 223 222 418 5.32E-75 235 STBPA_DANRE reviewed STAM-binding protein-like A (EC 3.4.19.-) stambpa amsh stambp Danio rerio (Zebrafish) (Brachydanio rerio) 418 0 GO:0008237; GO:0046872 0 0 0 PF01398;PF08969; Q6TXF1 CHOYP_TXNIP.1.1 m.40131 sp ARRD3_RAT 27.551 294 185 10 22 293 24 311 5.32E-24 105 ARRD3_RAT reviewed Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) 414 fat pad development [GO:0060613]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of multicellular organismal metabolic process [GO:0044252]; positive regulation of adrenergic receptor signaling pathway [GO:0071879]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; skin development [GO:0043588]; temperature homeostasis [GO:0001659] GO:0001659; GO:0005764; GO:0005769; GO:0005886; GO:0031651; GO:0043588; GO:0044252; GO:0051443; GO:0060613; GO:0071879; GO:0090327 0 0 0 PF02752;PF00339; Q8JHV9 CHOYP_IAP2.3.5 m.43282 sp BIR7A_XENLA 29.573 328 154 9 1170 1485 139 401 5.32E-39 154 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q92902 CHOYP_BRAFLDRAFT_126225.1.1 m.23534 sp HPS1_HUMAN 27.125 800 458 19 1 780 1 695 5.32E-64 230 HPS1_HUMAN reviewed Hermansky-Pudlak syndrome 1 protein HPS1 HPS Homo sapiens (Human) 700 lysosome organization [GO:0007040]; response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005737; GO:0005764; GO:0005887; GO:0007040; GO:0007601; GO:0016023; GO:0031085; GO:0046983; GO:0050896 0 0 0 0 Q9HAR2 CHOYP_BAI1.1.2 m.4434 sp AGRL3_HUMAN 27.728 559 343 19 392 914 508 1041 5.32E-48 190 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9R088 CHOYP_NEMVEDRAFT_V1G200323.1.1 m.23528 sp KITM_MOUSE 45.238 210 115 0 110 319 52 261 5.32E-65 209 KITM_MOUSE reviewed "Thymidine kinase 2, mitochondrial (EC 2.7.1.21) (Mt-TK)" Tk2 Mus musculus (Mouse) 270 deoxyribonucleotide metabolic process [GO:0009262]; DNA biosynthetic process [GO:0071897]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA replication [GO:0006264] GO:0004797; GO:0005524; GO:0005739; GO:0005743; GO:0006264; GO:0009262; GO:0032042; GO:0071897 0 0 0 PF01712; Q9Y3B2 CHOYP_NEMVEDRAFT_V1G238196.1.2 m.19362 sp EXOS1_HUMAN 58.974 195 77 3 15 207 1 194 5.32E-78 235 EXOS1_HUMAN reviewed Exosome complex component CSL4 (Exosome component 1) EXOSC1 CSL4 CGI-108 Homo sapiens (Human) 195 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; regulation of mRNA stability [GO:0043488]; rRNA processing [GO:0006364] GO:0000176; GO:0000178; GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006364; GO:0043488; GO:0043928 0 0 0 PF14382;PF10447; Q9Y3M9 CHOYP_contig_015536 m.18127 sp ZN337_HUMAN 44.615 65 35 1 345 409 616 679 5.32E-08 58.9 ZN337_HUMAN reviewed Zinc finger protein 337 ZNF337 Homo sapiens (Human) 751 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; D2YVK5 CHOYP_LOC100081235.2.2 m.37081 sp LECM_NOTSC 34.343 99 62 3 6 103 59 155 5.33E-14 66.6 LECM_NOTSC reviewed C-type lectin mannose-binding isoform (CTL) (Venom C-type lectin mannose binding isoform 1) 0 Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake) 158 0 GO:0005576; GO:0030246; GO:0046872 0 0 0 PF00059; O75382 CHOYP_TRIM3.31.58 m.33124 sp TRIM3_HUMAN 26.374 273 173 13 127 383 482 742 5.33E-12 70.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P13216 CHOYP_LOC100748436.1.1 m.33164 sp ADX_CHICK 64.602 113 39 1 85 197 23 134 5.33E-48 156 ADX_CHICK reviewed "Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Fragment)" FDX1 Gallus gallus (Chicken) 143 cholesterol metabolic process [GO:0008203]; hormone biosynthetic process [GO:0042446]; oxidation-reduction process [GO:0055114]; steroid biosynthetic process [GO:0006694] GO:0005759; GO:0006694; GO:0008203; GO:0009055; GO:0042446; GO:0046872; GO:0051537; GO:0055114 0 0 cd00207; PF00111; P62286 CHOYP_ASPM.2.4 m.19758 sp ASPM_CANLF 31.579 323 204 6 1 318 1441 1751 5.33E-29 120 ASPM_CANLF reviewed Abnormal spindle-like microcephaly-associated protein homolog ASPM Canis lupus familiaris (Dog) (Canis familiaris) 3469 cerebral cortex development [GO:0021987]; developmental growth [GO:0048589]; forebrain neuroblast division [GO:0021873]; maintenance of centrosome location [GO:0051661]; male gonad development [GO:0008584]; mitotic nuclear division [GO:0007067]; negative regulation of asymmetric cell division [GO:0045769]; negative regulation of neuron differentiation [GO:0045665]; neuronal stem cell population maintenance [GO:0097150]; neuron migration [GO:0001764]; oogenesis [GO:0048477]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuroblast proliferation [GO:0002052]; regulation of meiotic cell cycle [GO:0051445]; spermatogenesis [GO:0007283]; spindle assembly involved in meiosis [GO:0090306]; spindle localization [GO:0051653] GO:0001764; GO:0002052; GO:0005634; GO:0005737; GO:0007067; GO:0007283; GO:0008584; GO:0021873; GO:0021987; GO:0030496; GO:0036449; GO:0045665; GO:0045769; GO:0048477; GO:0048589; GO:0051445; GO:0051653; GO:0051661; GO:0072687; GO:0090263; GO:0090306; GO:0097150; GO:0097431 0 0 0 PF15780;PF00307;PF00612; P62972 CHOYP_UBIQP.4.13 m.19914 sp UBIQP_XENLA 98.361 122 2 0 1 122 16 137 5.33E-82 241 UBIQP_XENLA reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Xenopus laevis (African clawed frog) 167 0 GO:0005634; GO:0005737 0 0 0 PF00240; Q498J9 CHOYP_BRAFLDRAFT_227287.1.1 m.14669 sp MBLC1_XENLA 46.392 194 99 2 2 193 29 219 5.33E-51 168 MBLC1_XENLA reviewed Metallo-beta-lactamase domain-containing protein 1 (EC 3.-.-.-) mblac1 Xenopus laevis (African clawed frog) 233 0 GO:0016787; GO:0046872 0 0 0 PF00753; Q502M6 CHOYP_LOC755512.3.5 m.32842 sp ANR29_DANRE 39.759 166 98 1 1 164 45 210 5.33E-32 119 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q7ZUB2 CHOYP_RS17.8.11 m.30993 sp RS17_COTJA 82.031 128 22 1 12 139 1 127 5.33E-72 214 RS17_COTJA reviewed 40S ribosomal protein S17 RPS17 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 135 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00833; Q8C8R3 CHOYP_ANR44.5.5 m.65087 sp ANK2_MOUSE 31.21 157 108 0 5 161 626 782 5.33E-21 92 ANK2_MOUSE reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) Ank2 Mus musculus (Mouse) 3898 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; cardiac muscle contraction [GO:0060048]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cation channel activity [GO:2001257]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of SA node cell action potential [GO:0098907]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; T-tubule organization [GO:0033292] GO:0002027; GO:0005622; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0006874; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014069; GO:0014704; GO:0015459; GO:0016324; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0048471; GO:0050821; GO:0051117; GO:0051924; GO:0051928; GO:0055117; GO:0060048; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086014; GO:0086015; GO:0086036; GO:0086066; GO:0086070; GO:0086091; GO:0098904; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001257; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q8K039 CHOYP_K1143.1.1 m.63474 sp K1143_MOUSE 44 125 59 3 17 131 6 129 5.33E-26 99 K1143_MOUSE reviewed Uncharacterized protein KIAA1143 homolog 0 Mus musculus (Mouse) 155 0 0 0 0 0 PF15377; Q9H9D4 CHOYP_LOC100678246.1.1 m.17933 sp ZN408_HUMAN 35.821 67 41 2 220 285 494 559 5.33E-06 51.2 ZN408_HUMAN reviewed Zinc finger protein 408 (PR domain zinc finger protein 17) ZNF408 PFM14 PRDM17 Homo sapiens (Human) 720 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0042802; GO:0046872 0 0 0 PF13912; Q9UQ90 CHOYP_CEP76.1.1 m.6263 sp SPG7_HUMAN 53.524 454 204 3 339 787 304 755 5.33E-164 498 SPG7_HUMAN reviewed Paraplegin (EC 3.4.24.-) (Spastic paraplegia 7 protein) SPG7 CAR CMAR PGN Homo sapiens (Human) 795 anterograde axonal transport [GO:0008089]; cell adhesion [GO:0007155]; mitochondrion organization [GO:0007005]; nervous system development [GO:0007399]; proteolysis [GO:0006508] GO:0004176; GO:0004222; GO:0005524; GO:0005739; GO:0006508; GO:0007005; GO:0007155; GO:0007399; GO:0008089; GO:0008233; GO:0008270; GO:0016021; GO:0031966; GO:0051082; GO:1904115 0 0 0 PF00004;PF06480;PF01434; O08740 CHOYP_ISCW_ISCW008174.1.2 m.8360 sp RPB11_MOUSE 80 115 23 0 1 115 1 115 5.34E-66 197 RPB11_MOUSE reviewed DNA-directed RNA polymerase II subunit RPB11 (RNA polymerase II subunit B11) (DNA-directed RNA polymerase II subunit J) (RNA polymerase II 13.3 kDa subunit) (RPB14) Polr2j Rpo2-4 Mus musculus (Mouse) 117 piRNA metabolic process [GO:0034587]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0006366; GO:0030275; GO:0034587 0 0 0 0 P61866 CHOYP_LOC100908688.3.5 m.44315 sp RL12_CAEEL 65.517 58 20 0 1 58 106 163 5.34E-18 82.4 RL12_CAEEL reviewed 60S ribosomal protein L12 rpl-12 JC8.3 Caenorhabditis elegans 165 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0006412; GO:0019843; GO:0022625 0 0 cd00349; PF00298;PF03946; Q64104 CHOYP_TLL.1.1 m.27043 sp NR2E1_MOUSE 57.841 389 151 6 1 380 1 385 5.34E-158 452 NR2E1_MOUSE reviewed Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (mTll) Nr2e1 Tll Tlx Mus musculus (Mouse) 385 aggressive behavior [GO:0002118]; amygdala development [GO:0021764]; anterior commissure morphogenesis [GO:0021960]; behavioral fear response [GO:0001662]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; cell fate commitment [GO:0045165]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; dentate gyrus development [GO:0021542]; extracellular matrix organization [GO:0030198]; forebrain generation of neurons [GO:0021872]; glial cell migration [GO:0008347]; layer formation in cerebral cortex [GO:0021819]; long-term synaptic potentiation [GO:0060291]; negative regulation of apoptotic process [GO:0043066]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; olfactory bulb development [GO:0021772]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of stem cell proliferation [GO:2000648]; regulation of cell migration involved in sprouting angiogenesis [GO:0090049]; regulation of cellular component organization [GO:0051128]; regulation of dendrite morphogenesis [GO:0048814]; regulation of timing of neuron differentiation [GO:0060164]; retina development in camera-type eye [GO:0060041]; social behavior [GO:0035176]; somatic stem cell population maintenance [GO:0035019]; visual perception [GO:0007601] GO:0000122; GO:0001077; GO:0001078; GO:0001662; GO:0002118; GO:0003677; GO:0003707; GO:0005634; GO:0007420; GO:0007601; GO:0008270; GO:0008284; GO:0008347; GO:0019899; GO:0021542; GO:0021764; GO:0021772; GO:0021819; GO:0021872; GO:0021895; GO:0021960; GO:0021987; GO:0030198; GO:0035019; GO:0035176; GO:0042826; GO:0043010; GO:0043066; GO:0043565; GO:0045165; GO:0045665; GO:0045766; GO:0045787; GO:0048712; GO:0048814; GO:0051128; GO:0060041; GO:0060164; GO:0060291; GO:0090049; GO:2000178; GO:2000179; GO:2000648 0 0 0 PF00104;PF00105; Q69Z37 CHOYP_BRAFLDRAFT_131039.3.9 m.32019 sp SAM9L_MOUSE 27.389 157 91 5 15 149 678 833 5.34E-07 57.8 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6Q759 CHOYP_BRAFLDRAFT_120607.2.3 m.33779 sp SPG17_HUMAN 31.275 1231 700 32 781 1897 743 1941 5.34E-126 447 SPG17_HUMAN reviewed Sperm-associated antigen 17 (Projection protein PF6 homolog) SPAG17 Homo sapiens (Human) 2223 axoneme assembly [GO:0035082]; cilium movement [GO:0003341] GO:0003341; GO:0005654; GO:0005737; GO:0005874; GO:0031514; GO:0035082; GO:1990716 0 0 0 0 Q6R3M4 CHOYP_POLI.1.1 m.17325 sp POLI_MOUSE 51.145 393 178 4 45 431 28 412 5.34E-130 404 POLI_MOUSE reviewed DNA polymerase iota (EC 2.7.7.7) (Rad30 homolog B) Poli Rad30b Mus musculus (Mouse) 717 cellular response to UV-C [GO:0071494]; DNA replication [GO:0006260]; translesion synthesis [GO:0019985] GO:0003684; GO:0003887; GO:0005622; GO:0005634; GO:0006260; GO:0019985; GO:0043231; GO:0046872; GO:0071494 0 0 0 PF00817;PF11799;PF11798; Q8K3K9 CHOYP_LOC100934456.2.2 m.65906 sp GIMA4_RAT 32.864 213 121 7 137 329 31 241 5.34E-21 94.7 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q91WV7 CHOYP_SLC31.1.5 m.13052 sp SLC31_MOUSE 43.725 247 120 5 6 249 101 331 5.34E-62 211 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q9MBF8 CHOYP_LOC100376274.7.7 m.64553 sp DYH1B_CHLRE 26.418 670 445 13 1773 2424 2818 3457 5.34E-63 244 DYH1B_CHLRE reviewed "Dynein-1-beta heavy chain, flagellar inner arm I1 complex (1-beta DHC) (Dynein-1, subspecies f)" DHC10 IDA2 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4513 cilium movement involved in cell motility [GO:0060294]; inner dynein arm assembly [GO:0036159] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005930; GO:0008017; GO:0016887; GO:0031514; GO:0036156; GO:0036159; GO:0060294 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q9NZJ5 CHOYP_BRAFLDRAFT_98591.1.1 m.39947 sp E2AK3_HUMAN 37.228 1010 544 34 72 1027 105 1078 5.34E-173 540 E2AK3_HUMAN reviewed Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) EIF2AK3 PEK PERK Homo sapiens (Human) 1116 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; bone mineralization [GO:0030282]; calcium-mediated signaling [GO:0019722]; cellular response to amino acid starvation [GO:0034198]; cellular response to cold [GO:0070417]; cellular response to glucose starvation [GO:0042149]; chondrocyte development [GO:0002063]; eiF2alpha phosphorylation in response to endoplasmic reticulum stress [GO:0036492]; endocrine pancreas development [GO:0031018]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; insulin-like growth factor receptor signaling pathway [GO:0048009]; insulin secretion [GO:0030073]; negative regulation of myelination [GO:0031642]; negative regulation of translation [GO:0017148]; negative regulation of translational initiation in response to stress [GO:0032057]; ossification [GO:0001503]; peptidyl-serine phosphorylation [GO:0018105]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transcription from RNA polymerase I promoter [GO:0045943]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; protein homooligomerization [GO:0051260]; protein phosphorylation [GO:0006468]; regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:0060734]; regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902235]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; skeletal system development [GO:0001501] GO:0001501; GO:0001503; GO:0001525; GO:0002063; GO:0004672; GO:0004674; GO:0004694; GO:0005524; GO:0005737; GO:0005783; GO:0005789; GO:0006468; GO:0006919; GO:0006983; GO:0007029; GO:0010575; GO:0010628; GO:0010998; GO:0016020; GO:0017148; GO:0018105; GO:0019722; GO:0019899; GO:0019903; GO:0030073; GO:0030176; GO:0030282; GO:0030968; GO:0031018; GO:0031642; GO:0032057; GO:0034198; GO:0034976; GO:0036492; GO:0036499; GO:0042149; GO:0042802; GO:0042803; GO:0045943; GO:0046777; GO:0048009; GO:0048471; GO:0051260; GO:0060734; GO:0070417; GO:1900182; GO:1902235; GO:1990737 0 0 0 PF00069; Q9SZJ2 CHOYP_LOC100367312.2.13 m.3427 sp GRDP2_ARATH 40 285 156 5 5 278 15 295 5.34E-55 206 GRDP2_ARATH reviewed Glycine-rich domain-containing protein 2 (AtGRDP2) GRDP2 At4g37900 F20D10.20 Arabidopsis thaliana (Mouse-ear cress) 787 "auxin-activated signaling pathway [GO:0009734]; cellular response to osmotic stress [GO:0071470]; regulation of auxin mediated signaling pathway [GO:0010928]; regulation of photoperiodism, flowering [GO:2000028]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]" GO:0005198; GO:0006979; GO:0009650; GO:0009734; GO:0010928; GO:0071470; GO:0071944; GO:2000028 0 0 0 PF07173; Q9UPQ7 CHOYP_LOC593787.1.2 m.32263 sp PZRN3_HUMAN 30.601 183 122 4 4 182 3 184 5.34E-24 112 PZRN3_HUMAN reviewed E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) PDZRN3 KIAA1095 LNX3 SEMCAP3 Homo sapiens (Human) 1066 neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] GO:0004842; GO:0007528; GO:0008270; GO:0016567; GO:0016874; GO:0031594; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00595; B3EWZ6 CHOYP_LOC580670.6.6 m.40875 sp MLRP2_ACRMI 28.416 1471 845 64 1339 2695 722 2098 5.35E-111 403 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D3ZAT9 CHOYP_LOC100377010.1.16 m.1976 sp FAXC_RAT 36.626 243 137 5 43 273 98 335 5.35E-50 173 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; O61463 CHOYP_RLA2.7.9 m.23413 sp RLA2_CRYST 64.179 67 24 0 1 67 1 67 5.35E-24 92.4 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 P16157 CHOYP_ANK1.7.8 m.59940 sp ANK1_HUMAN 35.244 471 290 4 156 616 90 555 5.35E-72 256 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18947 CHOYP_LS14A.3.3 m.12698 sp VIT4_CAEEL 31.461 178 122 0 10 187 506 683 5.35E-21 93.2 VIT4_CAEEL reviewed Vitellogenin-4 vit-4 F59D8.2 Caenorhabditis elegans 1603 0 GO:0005319; GO:0005576; GO:0045735 0 0 0 PF09172;PF01347;PF00094; Q03601 CHOYP_NHL1.5.6 m.23967 sp NHL1_CAEEL 26 150 97 5 44 183 735 880 5.35E-07 55.8 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q20681 CHOYP_CRE_06881.1.1 m.62783 sp BAT38_CAEEL 26.577 222 131 9 47 255 183 385 5.35E-10 63.2 BAT38_CAEEL reviewed BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans 387 0 0 0 0 0 PF00651;PF00917; Q4QQQ7 CHOYP_BRAFLDRAFT_116913.1.1 m.43886 sp PO3F1_XENTR 72.768 224 36 4 150 355 148 364 5.35E-102 310 PO3F1_XENTR reviewed "POU domain, class 3, transcription factor 1" pou3f1 TTpA009b07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 375 "brain development [GO:0007420]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0007420; GO:0043565 0 0 0 PF00046;PF00157; Q6ZRF8 CHOYP_LOC100369754.9.10 m.65250 sp RN207_HUMAN 25.359 209 132 9 20 221 103 294 5.35E-12 72 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q923M0 CHOYP_LOC100903999.1.1 m.16840 sp PP16A_MOUSE 50 382 183 4 1 382 1 374 5.35E-120 371 PP16A_MOUSE reviewed Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3) Ppp1r16a Mypt3 Mus musculus (Mouse) 524 0 GO:0005829; GO:0005886; GO:0008599 0 0 0 PF12796; A1L0Y2 CHOYP_NEUL4.1.2 m.15391 sp NEUL4_XENTR 50.914 383 157 3 14 366 3 384 5.36E-123 391 NEUL4_XENTR reviewed Neuralized-like protein 4 neurl4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1477 0 GO:0005814 0 0 0 PF07177; A6NMZ7 CHOYP_LOC100486063.8.9 m.60985 sp CO6A6_HUMAN 21.32 788 558 24 1643 2410 430 1175 5.36E-33 145 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; B3A0P8 CHOYP_LOC100186797.1.1 m.63161 sp SCP2_LOTGI 24.855 173 109 7 33 203 145 298 5.36E-09 60.8 SCP2_LOTGI reviewed SCP domain-containing protein 2 (Uncharacterized shell protein 3) (LUSP-3) 0 Lottia gigantea (Giant owl limpet) 318 0 GO:0005576 0 0 0 PF00188; D3YXG0 CHOYP_BRAFLDRAFT_236936.1.6 m.3385 sp HMCN1_MOUSE 44.803 279 140 6 4 271 4531 4806 5.36E-62 218 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O08623 CHOYP_NEMVEDRAFT_V1G239529.2.2 m.28836 sp SQSTM_RAT 55.102 49 22 0 25 73 120 168 5.36E-13 68.6 SQSTM_RAT reviewed Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62) Sqstm1 Zip Rattus norvegicus (Rat) 439 apoptotic process [GO:0006915]; autophagy [GO:0006914]; cell differentiation [GO:0030154]; immune system process [GO:0002376]; macroautophagy [GO:0016236]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of macroautophagy [GO:0016239]; positive regulation of protein phosphorylation [GO:0001934]; protein heterooligomerization [GO:0051291]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of protein complex stability [GO:0061635]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000407; GO:0000932; GO:0001934; GO:0002376; GO:0005080; GO:0005770; GO:0005776; GO:0005783; GO:0006511; GO:0006914; GO:0006915; GO:0008270; GO:0016235; GO:0016236; GO:0016239; GO:0016605; GO:0030154; GO:0031410; GO:0042169; GO:0042803; GO:0043122; GO:0043130; GO:0044130; GO:0044753; GO:0044754; GO:0051291; GO:0061635; GO:0070062; GO:0097225; GO:0098779 0 0 0 PF00564;PF00569; O75343 CHOYP_GCYB2.1.1 m.24590 sp GCYB2_HUMAN 51.331 263 114 4 1 256 361 616 5.36E-81 258 GCYB2_HUMAN reviewed Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) GUCY1B2 Homo sapiens (Human) 617 cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; signal transduction [GO:0007165] GO:0004383; GO:0005525; GO:0005886; GO:0006182; GO:0007165; GO:0008074; GO:0020037; GO:0035556; GO:0046872 0 0 0 PF00211;PF07700;PF07701; P19492 CHOYP_LOC100533315.2.3 m.40370 sp GRIA3_RAT 21.908 283 172 9 39 281 118 391 5.36E-09 60.5 GRIA3_RAT reviewed "Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3)" Gria3 Glur3 Rattus norvegicus (Rat) 888 regulation of receptor recycling [GO:0001919]; response to fungicide [GO:0060992]; response to lithium ion [GO:0010226] GO:0001919; GO:0004970; GO:0004971; GO:0005234; GO:0008328; GO:0010226; GO:0014069; GO:0030054; GO:0030165; GO:0030425; GO:0032279; GO:0032281; GO:0043025; GO:0043083; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0043234; GO:0045211; GO:0060992 0 0 0 PF01094;PF00060;PF10613; P23880 CHOYP_ISCW_ISCW005791.1.1 m.53514 sp PP12_SCHPO 34.951 309 167 9 480 787 10 285 5.36E-52 187 PP12_SCHPO reviewed Serine/threonine-protein phosphatase PP1-2 (EC 3.1.3.16) (Suppressor protein SDS21) sds21 SPCC31H12.05c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 322 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; positive regulation of establishment of cell polarity regulating cell shape [GO:2000784]; protein dephosphorylation [GO:0006470] GO:0000164; GO:0004721; GO:0005634; GO:0005730; GO:0006470; GO:0007067; GO:0046872; GO:0051301; GO:0072357; GO:2000784 0 0 0 PF00149;PF16891; P27512 CHOYP_CD40.1.1 m.16191 sp TNR5_MOUSE 29.6 250 156 9 10 253 12 247 5.36E-18 87 TNR5_MOUSE reviewed Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CD antigen CD40) Cd40 Tnfrsf5 Mus musculus (Mouse) 289 apoptotic signaling pathway [GO:0097190]; B cell activation [GO:0042113]; cellular calcium ion homeostasis [GO:0006874]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; defense response to protozoan [GO:0042832]; defense response to virus [GO:0051607]; immune response-regulating cell surface receptor signaling pathway [GO:0002768]; inflammatory response [GO:0006954]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of GTPase activity [GO:0043547]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tyrosine phosphorylation of Stat1 protein [GO:0042511]; protein kinase B signaling [GO:0043491]; regulation of apoptotic process [GO:0042981]; regulation of immune response [GO:0050776]; regulation of immunoglobulin secretion [GO:0051023]; response to lipopolysaccharide [GO:0032496] GO:0001934; GO:0002768; GO:0003823; GO:0005031; GO:0005615; GO:0005737; GO:0005886; GO:0006874; GO:0006954; GO:0009897; GO:0009986; GO:0019899; GO:0030890; GO:0031625; GO:0032496; GO:0032735; GO:0035631; GO:0042113; GO:0042511; GO:0042832; GO:0042981; GO:0043123; GO:0043231; GO:0043406; GO:0043410; GO:0043491; GO:0043547; GO:0045944; GO:0048304; GO:0050776; GO:0051023; GO:0051092; GO:0051607; GO:0070062; GO:0071222; GO:0071260; GO:0090037; GO:0097190; GO:2000353 0 0 cd13407; PF00020; P34275 CHOYP_PDE8B.1.1 m.20359 sp IVD_CAEEL 52.163 393 187 1 20 411 6 398 5.36E-146 424 IVD_CAEEL reviewed Probable acyl-CoA dehydrogenase 6 (Probable isovaleryl-CoA dehydrogenase) (IVD) (EC 1.3.8.4) acdh-6 C02D5.1 Caenorhabditis elegans 408 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; leucine catabolic process [GO:0006552]; lipid homeostasis [GO:0055088] GO:0000062; GO:0003995; GO:0006552; GO:0009055; GO:0033539; GO:0050660; GO:0052890; GO:0055088 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3. 0 0 PF00441;PF02770;PF02771; P42577 CHOYP_LOC100533455.4.9 m.24718 sp FRIS_LYMST 79 100 21 0 1 100 68 167 5.36E-55 171 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P63182 CHOYP_CBLN1.2.2 m.49936 sp CBLN1_RAT 30.667 150 86 6 77 220 53 190 5.36E-11 62.8 CBLN1_RAT reviewed Cerebellin-1 (Precerebellin) [Cleaved into: Cerebellin (CER); [des-Ser1]-cerebellin (des-Ser(1)-cerebellin) ([des-Ser1]CER) (des-CER) (des-Ser1CER)] Cbln1 Rattus norvegicus (Rat) 193 cerebellar granule cell differentiation [GO:0021707]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; positive regulation of synapse assembly [GO:0051965]; protein secretion [GO:0009306] GO:0005576; GO:0007157; GO:0009306; GO:0021707; GO:0030054; GO:0045211; GO:0051965 0 0 0 PF00386; Q29599 CHOYP_LOC100767905.1.1 m.3929 sp OAS1_PIG 29.909 331 194 10 80 375 8 335 5.36E-36 137 OAS1_PIG reviewed 2'-5'-oligoadenylate synthase 1 ((2-5')oligo(A) synthase 1) (2-5A synthase 1) (EC 2.7.7.84) (p42 OAS) OAS1 Sus scrofa (Pig) 349 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; purine nucleotide biosynthetic process [GO:0006164] GO:0001730; GO:0003725; GO:0005524; GO:0005576; GO:0005634; GO:0005737; GO:0005739; GO:0005783; GO:0006164; GO:0045071; GO:0045087; GO:0046872; GO:0051607 0 0 0 PF01909;PF10421; Q4R4T9 CHOYP_LOC591690.1.1 m.30550 sp RANB3_MACFA 40 295 150 9 228 518 226 497 5.36E-47 174 RANB3_MACFA reviewed Ran-binding protein 3 (RanBP3) RANBP3 QccE-19613 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 499 intracellular transport [GO:0046907]; protein transport [GO:0015031] GO:0005634; GO:0005737; GO:0015031; GO:0046907 0 0 0 PF00638; Q5R7L3 CHOYP_AGAP_AGAP004985.2.2 m.30760 sp RM16_PONAB 34.821 112 62 3 38 146 27 130 5.36E-12 65.5 RM16_PONAB reviewed "39S ribosomal protein L16, mitochondrial (L16mt) (MRP-L16)" MRPL16 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 251 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005840; GO:0006412; GO:0019843 0 0 cd01433; PF00252; Q5XGC9 CHOYP_SRFB1.2.2 m.41283 sp SRFB1_XENTR 38.636 132 74 2 50 181 4 128 5.36E-21 98.6 SRFB1_XENTR reviewed Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) srfbp1 TTpA001g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 535 "maturation of SSU-rRNA [GO:0030490]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0030490; GO:0030686; GO:0048471 0 0 0 PF09073; Q95YM9 CHOYP_TRIADDRAFT_34144.1.1 m.54539 sp FGFR_HALRO 26.752 157 101 5 338 483 108 261 5.36E-08 59.3 FGFR_HALRO reviewed Fibroblast growth factor receptor (HrFGFR) (EC 2.7.10.1) FGFR Halocynthia roretzi (Sea squirt) (Cynthia roretzi) 763 positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0008284; GO:0016021 0 0 0 PF07679;PF07714; Q9GJT2 CHOYP_BRAFLDRAFT_79044.1.2 m.13754 sp ESTD_PIG 70.93 86 25 0 25 110 1 86 5.36E-40 138 ESTD_PIG reviewed S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) ESD Sus scrofa (Pig) 282 formaldehyde catabolic process [GO:0046294] GO:0016023; GO:0018738; GO:0046294; GO:0052689; GO:0070062 0 0 0 PF00756; Q9ULJ7 CHOYP_LOC593853.4.4 m.64196 sp ANR50_HUMAN 33.48 454 282 14 20 455 489 940 5.36E-45 172 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A0JM12 CHOYP_LOC579946.10.24 m.41446 sp MEG10_XENTR 38.049 205 105 10 16 219 170 353 5.37E-21 97.1 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A0JPI9 CHOYP_LOC100372392.8.8 m.62541 sp LR74A_RAT 35.88 432 257 4 153 580 51 466 5.37E-89 287 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A4IF63 CHOYP_TRIM2.30.59 m.35827 sp TRIM2_BOVIN 25.871 201 141 4 178 374 535 731 5.37E-12 70.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B5X5N3 CHOYP_LOC100894033.1.1 m.8338 sp SKA2_SALSA 29.811 265 145 6 1 262 1 227 5.37E-17 80.9 SKA2_SALSA reviewed Spindle and kinetochore-associated protein 2 (Protein FAM33A) ska2 fam33a Salmo salar (Atlantic salmon) 228 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; regulation of microtubule polymerization or depolymerization [GO:0031110] GO:0000940; GO:0005737; GO:0005876; GO:0007059; GO:0007067; GO:0008017; GO:0031110; GO:0051301 0 0 0 PF11362;PF16740; O70277 CHOYP_BRAFLDRAFT_99993.4.4 m.35104 sp TRIM3_RAT 34.884 86 55 1 82 167 500 584 5.37E-08 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75366 CHOYP_AVIL.1.1 m.36624 sp AVIL_HUMAN 28.485 825 555 17 99 900 6 818 5.37E-97 326 AVIL_HUMAN reviewed Advillin (p92) AVIL Homo sapiens (Human) 819 actin filament capping [GO:0051693]; cilium morphogenesis [GO:0060271]; cytoskeleton organization [GO:0007010]; nervous system development [GO:0007399]; positive regulation of neuron projection development [GO:0010976] GO:0003779; GO:0005737; GO:0007010; GO:0007399; GO:0010976; GO:0015629; GO:0030424; GO:0042995; GO:0043005; GO:0051693; GO:0060271 0 0 0 PF00626;PF02209; P28075 CHOYP_NEMVEDRAFT_V1G173323.2.2 m.55211 sp PSB5_RAT 78.846 208 44 0 69 276 51 258 5.37E-120 347 PSB5_RAT reviewed Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit X) Psmb5 Rattus norvegicus (Rat) 263 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004298; GO:0005634; GO:0005737; GO:0005839; GO:0051603 0 0 0 PF00227; P49193 CHOYP_RALB.1.1 m.57176 sp RALB_TODPA 48.555 346 174 2 82 427 1 342 5.37E-120 356 RALB_TODPA reviewed Retinal-binding protein (RALBP) 0 Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) 343 response to stimulus [GO:0050896]; transport [GO:0006810]; visual perception [GO:0007601] GO:0006810; GO:0007601; GO:0016021; GO:0050896 0 0 0 PF00650;PF13897; P83741 CHOYP_WNK2.1.2 m.38552 sp WNK1_MOUSE 68.966 377 112 3 274 648 192 565 5.37E-164 564 WNK1_MOUSE reviewed Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) Wnk1 Hsn2 Prkwnk1 Mus musculus (Mouse) 2377 intracellular signal transduction [GO:0035556]; ion transport [GO:0006811]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of phosphatase activity [GO:0010923]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of systemic arterial blood pressure [GO:0003084]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cellular process [GO:0050794]; regulation of ion homeostasis [GO:2000021] GO:0000287; GO:0003084; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006811; GO:0010923; GO:0019869; GO:0019870; GO:0019902; GO:0030291; GO:0032414; GO:0035556; GO:0046777; GO:0050794; GO:0090188; GO:2000021 0 0 0 PF12202;PF00069; P84316 CHOYP_EEF1A.1.3 m.18896 sp EF1A_HELZE 84 125 20 0 1 125 88 212 5.37E-71 221 EF1A_HELZE reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Helicoverpa zea (Corn earworm moth) (Heliothis zea) 413 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q6DER2 CHOYP_RL36.4.8 m.27560 sp RL36_XENTR 64.835 91 30 1 16 106 1 89 5.37E-33 114 RL36_XENTR reviewed 60S ribosomal protein L36 rpl36 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 105 brain development [GO:0007420]; cytoplasmic translation [GO:0002181]; regulation of cell cycle [GO:0051726] GO:0002181; GO:0003735; GO:0007420; GO:0022625; GO:0051726 0 0 0 PF01158; Q7JQD3 CHOYP_GELS2.1.2 m.25225 sp GELS1_LUMTE 68.75 144 43 2 2 143 68 211 5.37E-66 211 GELS1_LUMTE reviewed Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) 367 actin filament capping [GO:0051693]; actin filament fragmentation [GO:0030043]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; multicellular organism development [GO:0007275] GO:0003779; GO:0005509; GO:0005737; GO:0005856; GO:0007275; GO:0030041; GO:0030043; GO:0045010; GO:0051014; GO:0051693 0 0 0 PF00626; Q80T91 CHOYP_MEG10.69.91 m.54568 sp MEG11_MOUSE 36.214 243 140 10 89 330 264 492 5.37E-32 129 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q95XZ6 CHOYP_EIF4G1.1.2 m.33171 sp LAAT1_CAEEL 34.532 278 173 5 25 301 16 285 5.37E-52 176 LAAT1_CAEEL reviewed Lysosomal amino acid transporter 1 laat-1 Y43H11AL.2 Caenorhabditis elegans 311 amino acid homeostasis [GO:0080144]; arginine transport [GO:0015809]; lysine transport [GO:0015819] GO:0005765; GO:0015181; GO:0015189; GO:0015809; GO:0015819; GO:0031301; GO:0080144 0 0 0 PF04193; Q9C0E8 CHOYP_LNP.1.1 m.13766 sp LNP_HUMAN 48 325 148 6 1 312 1 317 5.37E-97 300 LNP_HUMAN reviewed Protein lunapark LNP KIAA1715 Homo sapiens (Human) 428 blood coagulation [GO:0007596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; endoplasmic reticulum tubular network organization [GO:0071786]; limb development [GO:0060173]; regulation of chondrocyte differentiation [GO:0032330] GO:0005789; GO:0007596; GO:0016021; GO:0032330; GO:0035115; GO:0042733; GO:0046872; GO:0060173; GO:0071782; GO:0071786 0 0 0 PF10058; D4B1Z7 CHOYP_ATEG_01760.1.1 m.21086 sp A2478_ARTBC 28.39 472 283 14 74 523 122 560 5.38E-39 153 A2478_ARTBC reviewed Uncharacterized FAD-linked oxidoreductase ARB_02478 (EC 1.-.-.-) ARB_02478 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) 565 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF08031;PF01565; O61491 CHOYP_LOC586889.1.1 m.57220 sp FLOT1_DROME 69.196 224 69 0 26 249 203 426 5.38E-99 298 FLOT1_DROME reviewed Flotillin-1 Flo1 Flo Flo-1 FLODM-1 CG8200 Drosophila melanogaster (Fruit fly) 426 multicellular organism development [GO:0007275] GO:0005198; GO:0005737; GO:0005886; GO:0007275; GO:0016600 0 0 0 PF01145;PF15975; O75095 CHOYP_LOC100371242.1.6 m.13849 sp MEGF6_HUMAN 36.41 390 184 15 142 482 817 1191 5.38E-45 172 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75355 CHOYP_LOC100533297.1.1 m.14638 sp ENTP3_HUMAN 28.504 421 253 13 22 406 54 462 5.38E-46 170 ENTP3_HUMAN reviewed Ectonucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) (EC 3.6.1.5) (CD39 antigen-like 3) (Ecto-ATP diphosphohydrolase 3) (Ecto-ATPDase 3) (Ecto-ATPase 3) (Ecto-apyrase 3) (HB6) ENTPD3 CD39L3 Homo sapiens (Human) 529 nucleoside diphosphate catabolic process [GO:0009134]; nucleoside triphosphate catabolic process [GO:0009143] GO:0005524; GO:0005886; GO:0009134; GO:0009143; GO:0016021; GO:0017110; GO:0017111 0 0 0 PF01150; P07572 CHOYP_LOC100497321.4.4 m.65789 sp POL_MPMV 22.963 270 164 11 28 284 69 307 5.38E-10 65.5 POL_MPMV reviewed Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) 867 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P15253 CHOYP_NEMVEDRAFT_V1G61368.1.1 m.42775 sp CALR_RABIT 73.636 110 29 0 1 110 257 366 5.38E-50 186 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P27987 CHOYP_LOC590949.2.2 m.19744 sp IP3KB_HUMAN 60.502 319 120 2 106 424 630 942 5.38E-130 401 IP3KB_HUMAN reviewed "Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)" ITPKB Homo sapiens (Human) 946 cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; common myeloid progenitor cell proliferation [GO:0035726]; inositol phosphate metabolic process [GO:0043647]; inositol trisphosphate metabolic process [GO:0032957]; MAPK cascade [GO:0000165]; myeloid cell homeostasis [GO:0002262]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neutrophil apoptotic process [GO:0033030]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of Ras protein signal transduction [GO:0046579]; positive thymic T cell selection [GO:0045059]; regulation of protein phosphorylation [GO:0001932]; signal transduction [GO:0007165] GO:0000165; GO:0001932; GO:0002262; GO:0005524; GO:0005634; GO:0005829; GO:0007165; GO:0007166; GO:0008440; GO:0016020; GO:0032957; GO:0033030; GO:0035726; GO:0043647; GO:0045059; GO:0045638; GO:0046579; GO:0046638; GO:0071277 0 0 0 PF03770; P86963 CHOYP_KCP2.1.1 m.28193 sp KCP2_PINMA 48.485 132 59 4 30 154 36 165 5.38E-30 122 KCP2_PINMA reviewed BPTI/Kunitz domain-containing protein 2 (Nacre serine protease inhibitor 1) (NSPI1) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 337 0 GO:0004867; GO:0005576 0 0 0 PF00014; Q0PMG2 CHOYP_BRAFLDRAFT_74469.3.3 m.53818 sp MDGA1_MOUSE 26.531 294 156 12 224 488 175 437 5.38E-06 54.3 MDGA1_MOUSE reviewed MAM domain-containing glycosylphosphatidylinositol anchor protein 1 Mdga1 Mus musculus (Mouse) 940 cerebral cortex radially oriented cell migration [GO:0021799]; neuron migration [GO:0001764] GO:0001764; GO:0005615; GO:0005794; GO:0005886; GO:0021799; GO:0045121; GO:0046658 0 0 cd06263; PF00629; Q27294 CHOYP_LOC100744767.1.2 m.18521 sp CAZ_DROME 53.968 63 29 0 140 202 114 176 5.38E-15 76.3 CAZ_DROME reviewed RNA-binding protein cabeza (P19) (Sarcoma-associated RNA-binding fly homolog) caz SARFH CG3606 Drosophila melanogaster (Fruit fly) 399 "adult locomotory behavior [GO:0008344]; compound eye development [GO:0048749]; larval locomotory behavior [GO:0008345]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; synaptic growth at neuromuscular junction [GO:0051124]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000166; GO:0000398; GO:0003729; GO:0005634; GO:0005654; GO:0005669; GO:0006367; GO:0008270; GO:0008344; GO:0008345; GO:0045887; GO:0048749; GO:0051124; GO:0071013 0 0 0 PF00076;PF00641; Q4V348 CHOYP_LOC100730443.1.1 m.57698 sp Z658B_HUMAN 27.586 377 212 15 2 341 312 664 5.38E-26 112 Z658B_HUMAN reviewed Zinc finger protein 658B ZNF658B Homo sapiens (Human) 819 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q6NXR4 CHOYP_TTI2.1.1 m.35068 sp TTI2_HUMAN 34.118 340 195 9 137 465 144 465 5.38E-37 145 TTI2_HUMAN reviewed TELO2-interacting protein 2 TTI2 C8orf41 Homo sapiens (Human) 508 0 0 0 0 0 PF10521; Q7SXL7 CHOYP_SODM.1.2 m.45532 sp FL2D_DANRE 49.65 143 70 2 7 147 8 150 5.38E-36 132 FL2D_DANRE reviewed Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (WT1-associated protein) (Wilms tumor 1-associating protein) wtap ch211-195e3.2 zgc:66202 Danio rerio (Zebrafish) (Brachydanio rerio) 423 "cell cycle [GO:0007049]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]" GO:0000381; GO:0005634; GO:0006397; GO:0007049; GO:0008380; GO:0016607; GO:0036396; GO:0042981; GO:0080009 0 0 0 PF17098; Q7TN88 CHOYP_LOC100378512.1.6 m.22021 sp PK1L2_MOUSE 25.371 607 392 14 4 595 1831 2391 5.38E-52 199 PK1L2_MOUSE reviewed Polycystic kidney disease protein 1-like 2 (PC1-like 2 protein) (Polycystin-1L2) Pkd1l2 Mus musculus (Mouse) 2461 detection of mechanical stimulus [GO:0050982] GO:0001965; GO:0005262; GO:0005509; GO:0016020; GO:0016021; GO:0030246; GO:0050982 0 0 0 PF02140;PF01825;PF00059;PF08016;PF01477;PF02010; Q80TC5 CHOYP_POGK.1.1 m.12800 sp POGK_MOUSE 37.956 137 81 3 151 284 197 332 5.38E-19 92.4 POGK_MOUSE reviewed Pogo transposable element with KRAB domain Pogk Kiaa1513 Mus musculus (Mouse) 607 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q8BZ25 CHOYP_TVAG_355070.1.1 m.57891 sp ANKK1_MOUSE 34.646 127 80 2 224 348 354 479 5.38E-12 70.5 ANKK1_MOUSE reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) 745 0 GO:0004674; GO:0005524 0 0 0 PF00023;PF12796;PF07714; Q9I7U4 CHOYP_TITIN.8.19 m.35868 sp TITIN_DROME 39.623 106 63 1 26 131 17704 17808 5.38E-15 73.9 TITIN_DROME reviewed Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) 18141 cell division [GO:0051301]; locomotion [GO:0040011]; mesoderm development [GO:0007498]; mitotic chromosome condensation [GO:0007076]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; regulation of hemocyte proliferation [GO:0035206]; sarcomere organization [GO:0045214]; sensory perception of pain [GO:0019233]; sister chromatid cohesion [GO:0007062]; skeletal muscle tissue development [GO:0007519]; somatic muscle development [GO:0007525]; visceral muscle development [GO:0007522] GO:0000794; GO:0003779; GO:0005863; GO:0005875; GO:0007062; GO:0007076; GO:0007498; GO:0007517; GO:0007519; GO:0007520; GO:0007522; GO:0007525; GO:0008307; GO:0016203; GO:0019233; GO:0030017; GO:0030018; GO:0031674; GO:0035206; GO:0040011; GO:0045214; GO:0051301 0 0 0 PF06582;PF00041;PF07679;PF00018; Q9Y2D1 CHOYP_RS2.2.10 m.5563 sp ATF5_HUMAN 48.75 80 38 1 268 344 196 275 5.38E-16 80.5 ATF5_HUMAN reviewed Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5) (Transcription factor ATFx) ATF5 ATFX Homo sapiens (Human) 282 "cerebellar granule cell precursor proliferation [GO:0021930]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cell cycle G2/M phase transition [GO:1902750]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; olfactory bulb interneuron development [GO:0021891]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; regulation of centrosome cycle [GO:0046605]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]" GO:0000977; GO:0000981; GO:0001228; GO:0003682; GO:0003700; GO:0003714; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005813; GO:0006355; GO:0006357; GO:0007623; GO:0008285; GO:0009791; GO:0015631; GO:0019900; GO:0021891; GO:0021930; GO:0035264; GO:0043066; GO:0043565; GO:0044212; GO:0045444; GO:0045892; GO:0045893; GO:0045944; GO:0046605; GO:0048712; GO:1902750 0 0 0 PF00170; Q9Y4P3 CHOYP_TBL2.1.1 m.29917 sp TBL2_HUMAN 52.32 388 178 2 60 444 59 442 5.38E-140 411 TBL2_HUMAN reviewed Transducin beta-like protein 2 (WS beta-transducin repeats protein) (WS-betaTRP) (Williams-Beuren syndrome chromosomal region 13 protein) TBL2 WBSCR13 UNQ563/PRO1125 Homo sapiens (Human) 447 cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; endoplasmic reticulum unfolded protein response [GO:0030968] GO:0005783; GO:0019901; GO:0030176; GO:0030968; GO:0031369; GO:0042149; GO:0044822; GO:0051219; GO:0071456 0 0 0 PF00400; O08762 CHOYP_BRAFLDRAFT_85664.8.10 m.38630 sp NETR_MOUSE 42.381 210 117 2 17 223 163 371 5.39E-49 176 NETR_MOUSE reviewed Neurotrypsin (EC 3.4.21.-) (Brain-specific serine protease 3) (BSSP-3) (Motopsin) (Serine protease 12) Prss12 Bssp3 Mus musculus (Mouse) 761 exocytosis [GO:0006887]; proteolysis [GO:0006508]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006508; GO:0006887; GO:0008233; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195; GO:0045202 0 0 cd00190; PF00051;PF00530;PF00089; O35929 CHOYP_LOC100119620.1.2 m.598 sp REM1_MOUSE 33.503 197 122 4 127 316 80 274 5.39E-21 94.7 REM1_MOUSE reviewed GTP-binding protein REM 1 (Rad and Gem-like GTP-binding protein 1) Rem1 Rem Mus musculus (Mouse) 297 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0016020 0 0 0 PF00071; P16157 CHOYP_ACA1_388490.3.3 m.64721 sp ANK1_HUMAN 33.574 277 162 4 59 318 232 503 5.39E-36 141 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P55108 CHOYP_BMP3.1.1 m.8964 sp GDF10_RAT 31.881 436 230 16 62 463 74 476 5.39E-58 201 GDF10_RAT reviewed Growth/differentiation factor 10 (GDF-10) (Bone morphogenetic protein 3B) (BMP-3B) (Bone-inducing protein) (BIP) Gdf10 Bmp3b Rattus norvegicus (Rat) 476 BMP signaling pathway [GO:0030509]; cell development [GO:0048468]; cerebellum development [GO:0021549]; negative regulation of osteoblast differentiation [GO:0045668]; osteoblast differentiation [GO:0001649]; ovulation cycle [GO:0042698]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; regulation of apoptotic process [GO:0042981]; regulation of MAPK cascade [GO:0043408]; regulation of ossification [GO:0030278]; response to transforming growth factor beta [GO:0071559]; SMAD protein signal transduction [GO:0060395] GO:0001649; GO:0005125; GO:0005160; GO:0005615; GO:0010862; GO:0021549; GO:0030278; GO:0030509; GO:0042698; GO:0042981; GO:0043408; GO:0045668; GO:0045669; GO:0048468; GO:0060395; GO:0071559 0 0 0 PF00019; Q08509 CHOYP_LOC100744369.1.1 m.56678 sp EPS8_MOUSE 29.965 564 297 20 62 571 17 536 5.39E-54 201 EPS8_MOUSE reviewed Epidermal growth factor receptor kinase substrate 8 Eps8 Mus musculus (Mouse) 821 actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360] GO:0003779; GO:0005903; GO:0005938; GO:0008344; GO:0008360; GO:0010458; GO:0014069; GO:0016601; GO:0017146; GO:0030054; GO:0030426; GO:0030832; GO:0031532; GO:0031982; GO:0032420; GO:0032587; GO:0035591; GO:0036336; GO:0045202; GO:0048149; GO:0048365; GO:0051016; GO:0051017; GO:0051764; GO:0070062; GO:0070358 0 0 0 PF08416;PF00018; Q10725 CHOYP_BRAFLDRAFT_266781.2.2 m.44659 sp FSDH_RALPI 31.975 319 195 8 6 314 5 311 5.39E-43 154 FSDH_RALPI reviewed Phenylserine dehydratase (EC 4.2.1.-) psdht Ralstonia pickettii (Burkholderia pickettii) 326 0 GO:0016829 0 0 0 PF00291; Q29RU1 CHOYP_AGAP_AGAP013102.1.1 m.50186 sp RT12_BOVIN 57.937 126 46 3 36 160 19 138 5.39E-41 137 RT12_BOVIN reviewed "28S ribosomal protein S12, mitochondrial (MRP-S12) (S12mt)" MRPS12 Bos taurus (Bovine) 139 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005763; GO:0032543; GO:0044822; GO:0070124; GO:0070125 0 0 cd03368; PF00164; Q6RUV5 CHOYP_RAC1.2.3 m.23406 sp RAC1_RAT 88.333 180 21 0 23 202 13 192 5.39E-120 340 RAC1_RAT reviewed Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) 192 "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure arrangement [GO:0048532]; auditory receptor cell morphogenesis [GO:0002093]; axon guidance [GO:0007411]; bone resorption [GO:0045453]; cell-cell junction organization [GO:0045216]; cell motility [GO:0048870]; cell proliferation [GO:0008283]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex GABAergic interneuron development [GO:0021894]; cerebral cortex radially oriented cell migration [GO:0021799]; chemotaxis [GO:0006935]; cochlea morphogenesis [GO:0090103]; dendrite morphogenesis [GO:0048813]; dopaminergic neuron differentiation [GO:0071542]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; engulfment of apoptotic cell [GO:0043652]; epithelial cell morphogenesis [GO:0003382]; G-protein coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; hyperosmotic response [GO:0006972]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; mast cell chemotaxis [GO:0002551]; negative regulation of interleukin-23 production [GO:0032707]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of DNA replication [GO:0045740]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane [GO:0072659]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; regulation of cell size [GO:0008361]; regulation of fibroblast migration [GO:0010762]; regulation of neuron maturation [GO:0014041]; regulation of respiratory burst [GO:0060263]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000139; GO:0001891; GO:0001934; GO:0002093; GO:0002551; GO:0003382; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005802; GO:0005829; GO:0005884; GO:0005925; GO:0006935; GO:0006972; GO:0007015; GO:0007186; GO:0007411; GO:0008283; GO:0008361; GO:0010592; GO:0010762; GO:0014041; GO:0016020; GO:0016601; GO:0017137; GO:0019897; GO:0019901; GO:0021799; GO:0021831; GO:0021894; GO:0030027; GO:0030032; GO:0030036; GO:0030041; GO:0030334; GO:0030838; GO:0031410; GO:0031901; GO:0032587; GO:0032707; GO:0034446; GO:0036464; GO:0042470; GO:0042826; GO:0043552; GO:0043652; GO:0045216; GO:0045453; GO:0045740; GO:0048532; GO:0048813; GO:0048870; GO:0048873; GO:0051022; GO:0051496; GO:0051668; GO:0051894; GO:0051932; GO:0060071; GO:0060263; GO:0070062; GO:0071260; GO:0071526; GO:0071542; GO:0072659; GO:0090023; GO:0090103; GO:0097178; GO:1900026 0 0 0 PF00071; Q6UX40 CHOYP_TM107.1.1 m.66024 sp TM107_HUMAN 48.889 135 69 0 2 136 3 137 5.39E-48 154 TM107_HUMAN reviewed Transmembrane protein 107 TMEM107 DC20 UNQ638/PRO1268 Homo sapiens (Human) 140 cilium assembly [GO:0042384]; embryonic digit morphogenesis [GO:0042733]; neural tube patterning [GO:0021532]; nonmotile primary cilium assembly [GO:0035058] GO:0016021; GO:0021532; GO:0035058; GO:0035869; GO:0042384; GO:0042733 0 0 0 PF14995; Q8TFN0 CHOYP_PAAG_04291.1.1 m.44852 sp NDK_EMENI 75.51 98 24 0 16 113 43 140 5.39E-52 163 NDK_EMENI reviewed Nucleoside diphosphate kinase (NDP kinase) (EC 2.7.4.6) (AnNDK) (NDK) swoH AN8216 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 153 anisotropic cell growth [GO:0051211]; CDP phosphorylation [GO:0061508]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; nucleoside triphosphate biosynthetic process [GO:0009142]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; UTP biosynthetic process [GO:0006228] GO:0004550; GO:0005524; GO:0005576; GO:0005622; GO:0005634; GO:0005758; GO:0005829; GO:0006163; GO:0006183; GO:0006220; GO:0006228; GO:0006241; GO:0009142; GO:0046872; GO:0051211; GO:0061508 0 0 0 PF00334; Q96MM6 CHOYP_LOC100207121.9.9 m.60845 sp HS12B_HUMAN 28.795 639 387 16 42 619 55 686 5.39E-84 280 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9FMR5 CHOYP_BRAFLDRAFT_140951.1.1 m.40225 sp VA714_ARATH 31.163 215 146 2 31 244 1 214 5.39E-43 148 VA714_ARATH reviewed Vesicle-associated membrane protein 714 (AtVAMP714) VAMP714 At5g22360 MWD9.16 Arabidopsis thaliana (Mouse-ear cress) 221 exocytosis [GO:0006887]; protein transport [GO:0015031]; response to salt stress [GO:0009651]; vesicle fusion [GO:0006906] GO:0000139; GO:0000149; GO:0005484; GO:0005773; GO:0005794; GO:0006887; GO:0006906; GO:0009651; GO:0015031; GO:0016021; GO:0031201 0 0 0 PF13774;PF00957; Q9NSI2 CHOYP_FAM207A.2.2 m.43096 sp F207A_HUMAN 27.826 230 144 6 1 208 1 230 5.39E-17 79.7 F207A_HUMAN reviewed Protein FAM207A FAM207A C21orf70 PRED56 Homo sapiens (Human) 230 0 0 0 0 0 0 Q9NUV9 CHOYP_GIMAP4.3.4 m.56705 sp GIMA4_HUMAN 42.353 255 131 5 5 247 22 272 5.39E-61 202 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9UL19 CHOYP_BRAFLDRAFT_119296.16.16 m.66633 sp HRSL4_HUMAN 37.805 82 48 1 12 93 6 84 5.39E-10 57.4 HRSL4_HUMAN reviewed Retinoic acid receptor responder protein 3 (EC 3.1.1.-) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein) RARRES3 RIG1 TIG3 Homo sapiens (Human) 164 lipid catabolic process [GO:0016042]; negative regulation of cell proliferation [GO:0008285]; phospholipid metabolic process [GO:0006644] GO:0004623; GO:0006644; GO:0008285; GO:0016021; GO:0016042 0 0 0 PF04970; Q9UPS8 CHOYP_ANKRD7.2.3 m.28445 sp ANR26_HUMAN 27.809 1068 619 23 1130 2119 716 1709 5.39E-69 262 ANR26_HUMAN reviewed Ankyrin repeat domain-containing protein 26 ANKRD26 KIAA1074 Homo sapiens (Human) 1709 0 GO:0005813 0 0 0 PF00023;PF12796;PF12001; Q9V3J1 CHOYP_LOC657235.1.1 m.1711 sp VATH_DROME 52.899 276 122 3 79 351 5 275 5.39E-101 308 VATH_DROME reviewed V-type proton ATPase subunit H (V-ATPase subunit H) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD) VhaSFD CG17332 Drosophila melanogaster (Fruit fly) 468 ATP hydrolysis coupled proton transport [GO:0015991]; determination of adult lifespan [GO:0008340]; dsRNA transport [GO:0033227] GO:0000221; GO:0005886; GO:0008340; GO:0015991; GO:0033181; GO:0033227; GO:0046961 0 0 0 PF11698; Q9VF81 CHOYP_LOC100369926.2.6 m.34243 sp TMTC4_DROME 22.995 187 113 4 546 732 462 617 5.39E-06 53.9 TMTC4_DROME reviewed Transmembrane and TPR repeat-containing protein CG5038 CG5038 Drosophila melanogaster (Fruit fly) 705 0 GO:0016021 0 0 0 PF08409;PF13414; B0BN95 CHOYP_HARB1.2.3 m.47201 sp HARB1_RAT 35.135 148 92 3 1 147 39 183 5.40E-19 84.7 HARB1_RAT reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) Harbi1 Rattus norvegicus (Rat) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; B0V207 CHOYP_F16A2.1.3 m.42903 sp F16A2_DANRE 45.656 587 256 13 1 532 1 579 5.40E-156 481 F16A2_DANRE reviewed FTS and Hook-interacting protein homolog (FHIP) (Protein FAM160A2) fam160a2 si:ch211-39h10.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1124 early endosome to late endosome transport [GO:0045022]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; lysosome organization [GO:0007040]; protein transport [GO:0015031] GO:0005829; GO:0007032; GO:0007040; GO:0008333; GO:0015031; GO:0045022; GO:0070695 0 0 0 PF10257; O46102 CHOYP_LOC551561.1.1 m.46053 sp PAPD1_DROME 27.848 316 180 9 297 566 158 471 5.40E-17 88.2 PAPD1_DROME reviewed "Poly(A) RNA polymerase, mitochondrial (DmMTPAP) (EC 2.7.7.19)" MTPAP CG11418 Drosophila melanogaster (Fruit fly) 612 mitochondrial mRNA polyadenylation [GO:0097222]; mRNA polyadenylation [GO:0006378]; tRNA stabilization [GO:0036416] GO:0005739; GO:0006378; GO:0036416; GO:0044822; GO:0097222 0 0 0 PF03828; O97788 CHOYP_FABP.2.2 m.60105 sp FABP4_PIG 34.091 132 84 2 20 151 3 131 5.40E-17 75.5 FABP4_PIG reviewed "Fatty acid-binding protein, adipocyte (AP2) (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)" FABP4 Sus scrofa (Pig) 132 regulation of inflammatory response [GO:0050727] GO:0005215; GO:0005504; GO:0005634; GO:0005737; GO:0050727 0 0 0 PF00061; P13590 CHOYP_BM1_12515.6.7 m.41009 sp NCAM1_CHICK 25.12 418 257 22 132 527 9 392 5.40E-06 55.1 NCAM1_CHICK reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) 1091 cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167] GO:0005886; GO:0007155; GO:0016021; GO:0030198; GO:0031175; GO:0048167 0 0 0 PF00041;PF07679; P30414 CHOYP_PPIG.1.1 m.63308 sp NKTR_HUMAN 43.672 403 165 11 38 396 7 391 5.40E-83 301 NKTR_HUMAN reviewed NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) [Includes: Putative peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Rotamase)] NKTR Homo sapiens (Human) 1462 protein folding [GO:0006457] GO:0003755; GO:0006457; GO:0016018; GO:0016020 0 0 0 PF00160; P42674 CHOYP_LOC581886.3.3 m.51843 sp BP10_PARLI 32.95 261 145 11 170 416 83 327 5.40E-24 110 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; Q03164 CHOYP_MLL1.1.1 m.12571 sp KMT2A_HUMAN 54.348 46 20 1 5 49 1151 1196 5.40E-09 64.3 KMT2A_HUMAN reviewed Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1 Homo sapiens (Human) 3969 "anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; circadian regulation of gene expression [GO:0032922]; definitive hemopoiesis [GO:0060216]; DNA methylation [GO:0006306]; embryonic hemopoiesis [GO:0035162]; exploration behavior [GO:0035640]; histone H3-K4 dimethylation [GO:0044648]; histone H3-K4 methylation [GO:0051568]; histone H3-K4 trimethylation [GO:0080182]; histone H4-K16 acetylation [GO:0043984]; homeostasis of number of cells within a tissue [GO:0048873]; membrane depolarization [GO:0051899]; negative regulation of cell proliferation [GO:0008285]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cellular response to drug [GO:2001040]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transporter activity [GO:0032411]; post-embryonic development [GO:0009791]; protein complex assembly [GO:0006461]; regulation of histone H3-K14 acetylation [GO:0071440]; regulation of histone H3-K27 acetylation [GO:1901674]; regulation of histone H3-K9 acetylation [GO:2000615]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to potassium ion [GO:0035864]; spleen development [GO:0048536]; transcription from RNA polymerase II promoter [GO:0006366]; visual learning [GO:0008542]" GO:0001046; GO:0003680; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006306; GO:0006366; GO:0006461; GO:0006915; GO:0008270; GO:0008285; GO:0008542; GO:0009791; GO:0009952; GO:0018024; GO:0018026; GO:0032411; GO:0032922; GO:0035097; GO:0035162; GO:0035640; GO:0035864; GO:0042800; GO:0042802; GO:0042803; GO:0043984; GO:0044212; GO:0044648; GO:0045322; GO:0045893; GO:0045944; GO:0048172; GO:0048536; GO:0048873; GO:0051568; GO:0051571; GO:0051899; GO:0060216; GO:0070577; GO:0071339; GO:0071440; GO:0080182; GO:1901674; GO:2000615; GO:2001040 0 0 0 PF05965;PF05964;PF00628;PF00856;PF02008; Q12955 CHOYP_TRIADDRAFT_51756.1.1 m.8332 sp ANK3_HUMAN 26.15 413 255 9 557 966 369 734 5.40E-27 123 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q13263 CHOYP_LOC100369929.1.5 m.32680 sp TIF1B_HUMAN 24.257 202 144 6 1 197 135 332 5.40E-09 58.9 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q3U6K5 CHOYP_SPAT6.1.1 m.11699 sp SPAT6_MOUSE 29.159 535 273 20 46 529 1 480 5.40E-42 160 SPAT6_MOUSE reviewed Spermatogenesis-associated protein 6 (Kinesin-related protein) Spata6 Hash Mus musculus (Mouse) 488 cell differentiation [GO:0030154]; motile cilium assembly [GO:0044458]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005576; GO:0007275; GO:0007283; GO:0030154; GO:0032027; GO:0044458; GO:0097224 0 0 0 PF14909; Q502M6 CHOYP_ANKH1.1.1 m.64608 sp ANR29_DANRE 40.288 139 83 0 1 139 62 200 5.40E-26 102 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5R9R4 CHOYP_LOC100376857.4.7 m.47468 sp RL7_PONAB 65.306 245 85 0 68 312 2 246 5.40E-110 322 RL7_PONAB reviewed 60S ribosomal protein L7 RPL7 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 247 ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0003677; GO:0003729; GO:0005730; GO:0005925; GO:0006364; GO:0016020; GO:0022625; GO:0042273; GO:0070062 0 0 0 PF00327;PF08079; Q5RHP9 CHOYP_LOC100179357.4.6 m.32035 sp ERIC3_HUMAN 37.5 424 199 12 1 385 1 397 5.40E-69 260 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q5TJ59 CHOYP_TLR3.5.6 m.51305 sp TLR3_BOVIN 23.552 518 296 18 2 429 259 766 5.40E-16 84 TLR3_BOVIN reviewed Toll-like receptor 3 (CD antigen CD283) TLR3 Bos taurus (Bovine) 904 defense response to virus [GO:0051607]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; response to dsRNA [GO:0043331]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224] GO:0002224; GO:0002756; GO:0003725; GO:0004872; GO:0004888; GO:0005769; GO:0005789; GO:0005887; GO:0006954; GO:0010008; GO:0032722; GO:0034138; GO:0043330; GO:0043331; GO:0045087; GO:0050729; GO:0051607 0 0 0 PF13516;PF13855;PF01582; Q5ZM16 CHOYP_LOC100378492.1.1 m.36585 sp RBM22_CHICK 68.473 406 97 6 51 448 30 412 5.40E-180 512 RBM22_CHICK reviewed Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) RBM22 RCJMB04_3g16 Gallus gallus (Chicken) 420 "cellular response to drug [GO:0035690]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of RNA splicing [GO:0033120]; spliceosomal snRNP assembly [GO:0000387]" GO:0000166; GO:0000387; GO:0000974; GO:0005487; GO:0005634; GO:0005737; GO:0017070; GO:0033120; GO:0035690; GO:0036002; GO:0045292; GO:0046872; GO:0071006; GO:0071007; GO:0090316 0 0 0 PF00076; Q67ER4 CHOYP_LOC100136190.1.1 m.9460 sp R113A_BOVIN 62.774 274 98 1 36 305 52 325 5.40E-132 382 R113A_BOVIN reviewed RING finger protein 113A (Zinc finger protein 183) RNF113A ZNF183 Bos taurus (Bovine) 343 "mRNA cis splicing, via spliceosome [GO:0045292]; snoRNA splicing [GO:0034247]" GO:0005684; GO:0008270; GO:0034247; GO:0045292 0 0 0 PF00642; Q7ZWG6 CHOYP_SLC46A1.1.1 m.9990 sp PCFT_DANRE 25.773 388 273 7 52 434 78 455 5.40E-34 136 PCFT_DANRE reviewed Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) 481 transmembrane transport [GO:0055085] GO:0005542; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q92047 CHOYP_BRAFLDRAFT_284774.3.3 m.25057 sp PIMT_DANRE 64.286 224 78 1 1 224 1 222 5.40E-104 303 PIMT_DANRE reviewed Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) pcmt Danio rerio (Zebrafish) (Brachydanio rerio) 228 0 GO:0004719; GO:0005737 0 0 0 0 Q96KG7 CHOYP_MEG11.6.25 m.37352 sp MEG10_HUMAN 37.671 292 162 13 191 480 348 621 5.40E-34 139 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q9UMZ3 CHOYP_PTPRQ.5.8 m.38608 sp PTPRQ_HUMAN 29.71 414 234 17 18 396 1912 2303 5.40E-31 129 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; A0JM12 CHOYP_MEGF6.4.59 m.2627 sp MEG10_XENTR 35.981 214 114 9 5 206 208 410 5.41E-25 106 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A6QPN6 CHOYP_BRAFLDRAFT_126371.3.3 m.66053 sp GILT_BOVIN 39.623 212 115 6 52 261 32 232 5.41E-42 147 GILT_BOVIN reviewed Gamma-interferon-inducible lysosomal thiol reductase (EC 1.8.-.-) (IFI30 protein) IFI30 Bos taurus (Bovine) 244 antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590] GO:0005576; GO:0005764; GO:0016667; GO:0042590 0 0 0 PF03227; O96790 CHOYP_AGRIN.1.5 m.4676 sp DPGN_DIPMA 35.831 307 126 12 516 752 27 332 5.41E-33 134 DPGN_DIPMA reviewed Serine protease inhibitor dipetalogastin (Dipetalin) (Fragment) 0 Dipetalogaster maximus (Blood-sucking bug) 351 negative regulation of coagulation [GO:0050819] GO:0004867; GO:0005576; GO:0050819 0 0 0 PF00050;PF07648; P54611 CHOYP_VATE.1.1 m.21420 sp VATE_DROME 65.044 226 79 0 57 282 1 226 5.41E-104 305 VATE_DROME reviewed V-type proton ATPase subunit E (V-ATPase subunit E) (V-ATPase 26 kDa subunit) (Vacuolar proton pump subunit E) Vha26 CG1088 Drosophila melanogaster (Fruit fly) 226 "apical protein localization [GO:0045176]; ATP hydrolysis coupled proton transport [GO:0015991]; terminal branching, open tracheal system [GO:0007430]; trachea morphogenesis [GO:0060439]" GO:0000221; GO:0005886; GO:0007430; GO:0015991; GO:0033181; GO:0045176; GO:0046961; GO:0060439 0 0 0 PF01991; P86982 CHOYP_contig_035457 m.40214 sp IMSP1_RUDPH 54.167 144 51 4 190 330 8 139 5.41E-42 146 IMSP1_RUDPH reviewed Insoluble matrix shell protein 1 (IMSP1) (Fragment) 0 Ruditapes philippinarum (Japanese littleneck clam) (Venerupis philippinarum) 148 0 GO:0005576 0 0 0 0 Q6P9F0 CHOYP_LOC100371901.1.1 m.10745 sp CCD62_HUMAN 35 300 190 3 225 520 21 319 5.41E-43 170 CCD62_HUMAN reviewed Coiled-coil domain-containing protein 62 (Protein TSP-NY) (Protein aaa) CCDC62 Homo sapiens (Human) 684 cellular response to estradiol stimulus [GO:0071392]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0030331; GO:0030374; GO:0045944; GO:0071392 0 0 0 0 Q6UX98 CHOYP_LOC100372805.1.1 m.25288 sp ZDH24_HUMAN 31.429 210 140 3 112 318 73 281 5.41E-30 118 ZDH24_HUMAN reviewed Probable palmitoyltransferase ZDHHC24 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 24) (DHHC-24) ZDHHC24 UNQ2528/PRO6027 Homo sapiens (Human) 284 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q75UR0 CHOYP_BRAFLDRAFT_126668.2.2 m.56904 sp ANO5_MOUSE 27.74 876 445 22 41 792 50 861 5.41E-74 265 ANO5_MOUSE reviewed Anoctamin-5 (Gnathodiaphyseal dysplasia 1 protein homolog) (Transmembrane protein 16E) Ano5 Gdd1 Tmem16e Mus musculus (Mouse) 904 chloride transport [GO:0006821] GO:0005229; GO:0005622; GO:0005789; GO:0005886; GO:0006821; GO:0016021; GO:0031982 0 0 0 PF16178;PF04547; Q99NG0 CHOYP_ARIP4.1.3 m.5789 sp ARIP4_MOUSE 42.69 171 78 5 1 153 574 742 5.41E-35 134 ARIP4_MOUSE reviewed Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) (Steroid receptor-interacting SNF2 domain-containing protein-like) Rad54l2 Arip4 Srisnf2l Mus musculus (Mouse) 1466 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003677; GO:0003712; GO:0004386; GO:0005524; GO:0005634; GO:0016607; GO:0016887; GO:0019901; GO:0045944 0 0 0 PF00271;PF00176; Q9BLG0 CHOYP_TNNC.1.1 m.66691 sp TNNC_TODPA 66.901 142 47 0 6 147 5 146 5.41E-65 197 TNNC_TODPA reviewed Troponin C (TN-C) 0 Todarodes pacificus (Japanese flying squid) (Ommastrephes pacificus) 148 0 GO:0005509 0 0 0 PF13499; Q9QXW2 CHOYP_FBXW5.1.1 m.51733 sp FBXW5_MOUSE 29.897 194 132 2 11 200 9 202 5.41E-19 94.7 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9VFK6 CHOYP_LOC101237965.2.4 m.62046 sp KMT5A_DROME 31.746 126 79 4 36 156 555 678 5.41E-14 72.4 KMT5A_DROME reviewed Histone-lysine N-methyltransferase pr-set7 (EC 2.1.1.43) (Lysine N-methyltransferase 5A) (PR/SET domain-containing protein 07) (dSET8) pr-set7 KMT5A CG3307 Drosophila melanogaster (Fruit fly) 691 "cell division [GO:0051301]; chromosome condensation [GO:0030261]; DNA damage checkpoint [GO:0000077]; histone H4-K20 monomethylation [GO:0034771]; histone methylation [GO:0016571]; mitotic nuclear division [GO:0007067]; negative regulation of histone acetylation [GO:0035067]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000077; GO:0005634; GO:0005700; GO:0006351; GO:0006355; GO:0007067; GO:0016571; GO:0030261; GO:0034771; GO:0035067; GO:0042799; GO:0051301 0 0 0 PF00856; A0JPI9 CHOYP_LOC100183078.1.1 m.55899 sp LR74A_RAT 29.688 448 308 5 12 457 24 466 5.42E-63 215 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A8MRT5 CHOYP_contig_025136 m.28616 sp NPIB5_HUMAN 33.028 109 69 3 32 140 1014 1118 5.42E-06 50.8 NPIB5_HUMAN reviewed Nuclear pore complex-interacting protein family member B5 NPIPB5 Homo sapiens (Human) 1133 0 GO:0016021 0 0 0 0 B2RXR6 CHOYP_AASI_0340.1.2 m.21660 sp ANR44_MOUSE 34 350 222 2 7 351 54 399 5.42E-57 202 ANR44_MOUSE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) Ankrd44 Mus musculus (Mouse) 993 0 0 0 0 0 PF12796; H2A0M7 CHOYP_DYAK_GE13192.1.2 m.6772 sp PLSP_PINMG 43.605 172 92 2 18 184 576 747 5.42E-38 144 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O57592 CHOYP_LOC100366813.1.6 m.2829 sp RL7A_TAKRU 76.563 192 43 1 2 193 72 261 5.42E-106 308 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O75832 CHOYP_TVAG_297150.1.1 m.19904 sp PSD10_HUMAN 38.931 131 71 4 185 309 70 197 5.42E-16 81.6 PSD10_HUMAN reviewed 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)) PSMD10 Homo sapiens (Human) 226 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; apoptotic process [GO:0006915]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth [GO:0030307]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; proteasome regulatory particle assembly [GO:0070682]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000122; GO:0000165; GO:0000209; GO:0000502; GO:0002223; GO:0002479; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005838; GO:0006521; GO:0006915; GO:0007253; GO:0008134; GO:0030307; GO:0031145; GO:0031398; GO:0032088; GO:0032436; GO:0033209; GO:0038061; GO:0038095; GO:0043066; GO:0043161; GO:0043409; GO:0043488; GO:0043518; GO:0045111; GO:0045737; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070682; GO:0090090; GO:0090201; GO:0090263 0 0 0 PF00023;PF12796; O97649 CHOYP_UCP2.2.3 m.2640 sp UCP3_PIG 56.198 121 53 0 4 124 174 294 5.42E-45 151 UCP3_PIG reviewed Mitochondrial uncoupling protein 3 (UCP 3) (Solute carrier family 25 member 9) UCP3 SLC25A9 Sus scrofa (Pig) 308 mitochondrial transport [GO:0006839]; translation [GO:0006412] GO:0003735; GO:0005743; GO:0006412; GO:0006839; GO:0016021 0 0 0 PF00153; P10079 CHOYP_LOC100632098.10.13 m.51165 sp FBP1_STRPU 54.907 377 170 0 7 383 178 554 5.42E-130 406 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P32018 CHOYP_LOC568379.1.1 m.66354 sp COEA1_CHICK 26.277 137 93 4 1 134 1074 1205 5.42E-06 53.5 COEA1_CHICK reviewed Collagen alpha-1(XIV) chain (Undulin) COL14A1 Gallus gallus (Chicken) 1888 cell adhesion [GO:0007155] GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00041;PF00092; P36573 CHOYP_LOC101156514.1.1 m.23655 sp LEC1_CAEEL 36.508 126 76 3 1 124 150 273 5.42E-14 70.9 LEC1_CAEEL reviewed 32 kDa beta-galactoside-binding lectin (32 kDa GBP) lec-1 W09H1.6 Caenorhabditis elegans 279 0 GO:0016936; GO:0030246; GO:0045121; GO:0060102 0 0 0 PF00337; P62154 CHOYP_CALM.47.50 m.58815 sp CALM_LOCMI 74.15 147 38 0 2 148 3 149 5.42E-75 223 CALM_LOCMI reviewed Calmodulin (CaM) 0 Locusta migratoria (Migratory locust) 149 0 GO:0005509 0 0 0 PF13499; P62914 CHOYP_RL11.6.7 m.49989 sp RL11_RAT 82.243 107 19 0 1 107 72 178 5.42E-61 187 RL11_RAT reviewed 60S ribosomal protein L11 Rpl11 Rattus norvegicus (Rat) 178 negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; protein localization to nucleus [GO:0034504]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0019843; GO:0022625; GO:0022626; GO:0034504; GO:0042975; GO:0043433 0 0 0 PF00281;PF00673; Q3T0J3 CHOYP_AGAP_AGAP004985.1.2 m.20274 sp RM16_BOVIN 41.872 203 107 3 55 254 37 231 5.42E-47 159 RM16_BOVIN reviewed "39S ribosomal protein L16, mitochondrial (L16mt) (MRP-L16)" MRPL16 Bos taurus (Bovine) 251 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005762; GO:0019843; GO:0032543; GO:0070124; GO:0070125 0 0 cd01433; PF00252; Q5ZM71 CHOYP_ISCW_ISCW017342.1.1 m.62057 sp SP20H_CHICK 41.404 413 227 7 4 404 5 414 5.42E-101 332 SP20H_CHICK reviewed Transcription factor SPT20 homolog SUPT20H FAM48A RCJMB04_2p6 Gallus gallus (Chicken) 687 gastrulation [GO:0007369] GO:0000124; GO:0003712; GO:0007369 0 0 0 PF12090; Q6DFV8 CHOYP_BRAFLDRAFT_80496.2.10 m.21674 sp VWDE_MOUSE 25.843 356 226 15 139 483 292 620 5.42E-16 86.7 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q8AWF2 CHOYP_NACA.2.9 m.11875 sp NACA_ORENI 71.622 222 44 5 26 235 1 215 5.42E-85 254 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q8CI17 CHOYP_NEMVEDRAFT_V1G207511.5.5 m.62528 sp MB213_MOUSE 26.708 161 104 6 357 512 277 428 5.42E-06 52.8 MB213_MOUSE reviewed Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) 429 0 0 0 0 0 PF03281; Q8NFZ8 CHOYP_PHUM_PHUM068980.4.5 m.56739 sp CADM4_HUMAN 28.755 233 134 11 127 348 114 325 5.42E-13 75.5 CADM4_HUMAN reviewed Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2) CADM4 IGSF4C NECL4 TSLL2 Homo sapiens (Human) 388 cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0008037; GO:0042803; GO:0050839; GO:0070062 0 0 0 PF08205;PF07686; Q9ESN6 CHOYP_TRIM2.23.59 m.33003 sp TRIM2_MOUSE 30.392 204 127 8 114 310 536 731 5.42E-13 73.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H251 CHOYP_LOC660465.1.2 m.3799 sp CAD23_HUMAN 30.575 1426 863 46 94 1483 87 1421 5.42E-138 483 CAD23_HUMAN reviewed Cadherin-23 (Otocadherin) CDH23 KIAA1774 KIAA1812 UNQ1894/PRO4340 Homo sapiens (Human) 3354 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium ion transport [GO:0006816]; equilibrioception [GO:0050957]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; locomotory behavior [GO:0007626]; photoreceptor cell maintenance [GO:0045494]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0005509; GO:0005886; GO:0006816; GO:0007156; GO:0007601; GO:0007605; GO:0007626; GO:0016020; GO:0016021; GO:0016339; GO:0032420; GO:0045494; GO:0050896; GO:0050953; GO:0050957; GO:0051480; GO:0060122 0 0 0 PF00028; Q9NY59 CHOYP_SMPD3.1.1 m.7655 sp NSMA2_HUMAN 33.131 329 188 7 158 464 328 646 5.42E-52 189 NSMA2_HUMAN reviewed Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) SMPD3 Homo sapiens (Human) 655 cell cycle [GO:0007049]; glycosphingolipid metabolic process [GO:0006687]; hematopoietic progenitor cell differentiation [GO:0002244]; peptide hormone secretion [GO:0030072]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of exosomal secretion [GO:1903543]; sphingomyelin catabolic process [GO:0006685] GO:0000137; GO:0000139; GO:0002244; GO:0004767; GO:0005886; GO:0006685; GO:0006687; GO:0007049; GO:0030072; GO:0046872; GO:1903543; GO:2000304 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF03372; B3EWZ6 CHOYP_LOC100183059.3.4 m.29252 sp MLRP2_ACRMI 39.344 183 89 6 186 366 1395 1557 5.43E-26 116 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B4N937 CHOYP_HTRA2.1.1 m.10430 sp HTRA2_DROWI 45.455 330 166 8 106 422 105 433 5.43E-85 269 HTRA2_DROWI reviewed "Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2)" HtrA2 GK12147 Drosophila willistoni (Fruit fly) 434 apoptotic process [GO:0006915] GO:0004252; GO:0005758; GO:0006915; GO:0016021; GO:0031966 0 0 0 PF13180; O43290 CHOYP_SART1.1.1 m.14398 sp SNUT1_HUMAN 54.962 262 101 9 542 796 549 800 5.43E-75 263 SNUT1_HUMAN reviewed U4/U6.U5 tri-snRNP-associated protein 1 (SNU66 homolog) (hSnu66) (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (hSART-1) (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (allergen Hom s 1) SART1 Homo sapiens (Human) 800 "cell cycle arrest [GO:0007050]; intrinsic apoptotic signaling pathway [GO:0097193]; maturation of 5S rRNA [GO:0000481]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; spliceosomal snRNP assembly [GO:0000387]" GO:0000387; GO:0000398; GO:0000481; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0007050; GO:0015030; GO:0044822; GO:0045292; GO:0045585; GO:0046540; GO:0071013; GO:0097193 0 0 0 PF03343; O70277 CHOYP_BRAFLDRAFT_255130.2.3 m.23964 sp TRIM3_RAT 30 120 79 3 76 191 625 743 5.43E-09 58.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P0CT39 CHOYP_LOC100495679.1.2 m.52243 sp TF26_SCHPO 23.014 491 299 18 67 538 402 832 5.43E-11 69.3 TF26_SCHPO reviewed Transposon Tf2-6 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-6 SPAC27E2.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P23953 CHOYP_EST1C.1.2 m.13763 sp EST1C_MOUSE 32.288 542 303 19 14 531 9 510 5.43E-74 248 EST1C_MOUSE reviewed Carboxylesterase 1C (EC 3.1.1.1) (Liver carboxylesterase N) (Lung surfactant convertase) (PES-N) Ces1c Es1 Mus musculus (Mouse) 554 0 GO:0005615; GO:0005788; GO:0016788; GO:0052689 0 0 0 PF00135; P55214 CHOYP_CASP7.7.23 m.22859 sp CASP7_MESAU 25.155 322 167 12 3 317 45 299 5.43E-14 74.7 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 P58375 CHOYP_MYEF2.1.1 m.19002 sp RL30_SPOFR 84.536 97 15 0 35 131 1 97 5.43E-56 173 RL30_SPOFR reviewed 60S ribosomal protein L30 RpL30 Spodoptera frugiperda (Fall armyworm) 113 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01248; P62752 CHOYP_RPL23A.2.3 m.50278 sp RL23A_RAT 77.477 111 25 0 59 169 31 141 5.43E-54 171 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; Q03601 CHOYP_NHL1.2.6 m.2492 sp NHL1_CAEEL 34.127 126 64 5 9 117 42 165 5.43E-11 68.6 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q26261 CHOYP_UNC5.1.1 m.23807 sp UNC5_CAEEL 42.105 57 28 2 238 294 273 324 5.43E-07 54.7 UNC5_CAEEL reviewed Netrin receptor unc-5 (Uncoordinated protein 5) unc-5 B0273.4 Caenorhabditis elegans 919 commissural neuron axon guidance [GO:0071679]; dorsal/ventral axon guidance [GO:0033563]; gonad morphogenesis [GO:0035262]; mesodermal cell migration [GO:0008078]; motor neuron axon guidance [GO:0008045]; nematode male tail tip morphogenesis [GO:0045138]; positive regulation of axon extension [GO:0045773]; positive regulation of locomotion [GO:0040017] GO:0005042; GO:0005887; GO:0008045; GO:0008078; GO:0033563; GO:0035262; GO:0040017; GO:0045138; GO:0045773; GO:0071679; GO:1990782 0 0 0 PF00531;PF13895;PF00090;PF00791; Q497B8 CHOYP_KDM8.1.1 m.43721 sp KDM8_RAT 45.346 419 204 8 2 417 13 409 5.43E-122 363 KDM8_RAT reviewed Lysine-specific demethylase 8 (EC 1.14.11.27) (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5) Kdm8 Jmjd5 Rattus norvegicus (Rat) 414 "G2/M transition of mitotic cell cycle [GO:0000086]; histone H3-K36 demethylation [GO:0070544]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000086; GO:0003682; GO:0005634; GO:0006351; GO:0045893; GO:0046872; GO:0051864; GO:0070544 0 0 0 0 Q498M5 CHOYP_F16A2.1.3 m.42902 sp SH3R2_RAT 39.359 437 198 9 11 380 11 447 5.43E-89 298 SH3R2_RAT reviewed Putative E3 ubiquitin-protein ligase SH3RF2 (EC 6.3.2.-) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (SH3 domain-containing RING finger protein 2) Sh3rf2 Ppp1r39 Rnf158 Rattus norvegicus (Rat) 735 negative regulation of phosphatase activity [GO:0010923]; protein ubiquitination [GO:0016567] GO:0004864; GO:0005654; GO:0008157; GO:0008270; GO:0010923; GO:0016567; GO:0016874; GO:0019902 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00018;PF07653;PF00097; Q54P70 CHOYP_DICPUDRAFT_147269.1.1 m.34818 sp Y4757_DICDI 36.719 128 73 5 510 633 639 762 5.43E-11 70.9 Y4757_DICDI reviewed OTU domain-containing protein DDB_G0284757 (EC 3.1.2.-) DDB_G0284757 Dictyostelium discoideum (Slime mold) 766 0 GO:0008234 0 0 0 PF02338; Q6GPV5 CHOYP_ARALYDRAFT_496711.1.1 m.58259 sp RN181_XENLA 38.542 96 59 0 612 707 30 125 5.43E-16 79.3 RN181_XENLA reviewed E3 ubiquitin-protein ligase RNF181 (EC 6.3.2.-) (RING finger protein 181) rnf181 Xenopus laevis (African clawed frog) 156 protein ubiquitination [GO:0016567] GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q9BZ19 CHOYP_LOC100374676.1.1 m.61638 sp ANR60_HUMAN 38.14 215 130 2 18 229 94 308 5.43E-44 160 ANR60_HUMAN reviewed Ankyrin repeat domain-containing protein 60 ANKRD60 C20orf86 Homo sapiens (Human) 345 0 0 0 0 0 PF12796; Q9CQY2 CHOYP_BRAFLDRAFT_221294.2.2 m.52722 sp RAM_MOUSE 37.079 89 47 1 63 142 4 92 5.43E-09 55.5 RAM_MOUSE reviewed RNMT-activating mini protein (RAM) (Protein FAM103A1) Fam103a1 Mus musculus (Mouse) 119 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031] GO:0003723; GO:0005634; GO:0005845; GO:0006370; GO:0032259; GO:0036031; GO:0044822 0 0 0 PF15320; Q9EQT3 CHOYP_LOC100368648.1.1 m.63375 sp RHOU_MOUSE 65.766 222 61 3 27 247 53 260 5.43E-98 290 RHOU_MOUSE reviewed Rho-related GTP-binding protein RhoU (Rho GTPase-like protein ARHU) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1) Rhou Arhu G28k Wrch1 Mus musculus (Mouse) 261 actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of protein targeting to mitochondrion [GO:1903955]; Rac protein signal transduction [GO:0016601]; regulation of cell shape [GO:0008360] GO:0000082; GO:0000139; GO:0002102; GO:0003924; GO:0005525; GO:0005886; GO:0005925; GO:0007010; GO:0008360; GO:0016601; GO:0030036; GO:0042995; GO:0046872; GO:1903955 0 0 0 PF00071; Q9JI90 CHOYP_LOC100832737.1.1 m.47866 sp RNF14_MOUSE 28.6 500 266 14 27 476 9 467 5.43E-46 172 RNF14_MOUSE reviewed E3 ubiquitin-protein ligase RNF14 (EC 6.3.2.-) (Androgen receptor-associated protein 54) (Protein Triad2) (RING finger protein 14) Rnf14 Ara54 Triad2 Mus musculus (Mouse) 485 "positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription, DNA-templated [GO:0045893]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000209; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007165; GO:0008270; GO:0016874; GO:0019787; GO:0031624; GO:0032436; GO:0042787; GO:0045893; GO:0050681; GO:0060765; GO:0061630 0 0 0 PF01485;PF05773; A5PJP1 CHOYP_ISCW_ISCW004420.4.8 m.12282 sp BL1S3_BOVIN 32.967 91 60 1 52 142 105 194 5.44E-06 47.4 BL1S3_BOVIN reviewed Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) BLOC1S3 Bos taurus (Bovine) 200 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; eye development [GO:0001654]; melanosome organization [GO:0032438]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; platelet activation [GO:0030168]; platelet dense granule organization [GO:0060155]; positive regulation of natural killer cell activation [GO:0032816]; response to drug [GO:0042493]; secretion of lysosomal enzymes [GO:0033299] GO:0001654; GO:0008089; GO:0008320; GO:0016197; GO:0030133; GO:0030168; GO:0031083; GO:0031175; GO:0032402; GO:0032438; GO:0032816; GO:0033299; GO:0035646; GO:0042493; GO:0048490; GO:0060155; GO:1904115 0 0 0 PF15753; B1WB06 CHOYP_LOC100373794.2.5 m.12806 sp MET24_XENTR 28.517 263 141 12 64 295 103 349 5.44E-17 83.6 MET24_XENTR reviewed Methyltransferase-like protein 24 (EC 2.1.1.-) mettl24 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 353 0 GO:0005576; GO:0008168 0 0 0 PF13383; O96064 CHOYP_LOC100373653.2.3 m.43038 sp MYSP_MYTGA 83.539 243 39 1 119 361 504 745 5.44E-129 393 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; Q0ZM14 CHOYP_FAT.1.2 m.10451 sp PCD15_CHICK 30.744 309 171 13 113 406 89 369 5.44E-24 110 PCD15_CHICK reviewed Protocadherin-15 Pcdh15 Gallus gallus (Chicken) 1899 actin filament bundle assembly [GO:0051017]; adult walking behavior [GO:0007628]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in equilibrioception [GO:0050973]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of an epithelium [GO:0002009]; multicellular organism growth [GO:0035264]; nonmotile primary cilium assembly [GO:0035058]; righting reflex [GO:0060013]; startle response [GO:0001964]; visual perception [GO:0007601] GO:0001750; GO:0001964; GO:0002009; GO:0005509; GO:0005737; GO:0005886; GO:0007156; GO:0007601; GO:0007628; GO:0016021; GO:0032420; GO:0035058; GO:0035264; GO:0050910; GO:0050973; GO:0051017; GO:0060013; GO:0060088 0 0 0 PF00028; Q56A24 CHOYP_KLH24.2.6 m.24951 sp KLH24_RAT 28.936 470 305 7 44 507 43 489 5.44E-64 222 KLH24_RAT reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) Klhl24 Dre1 Rattus norvegicus (Rat) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q5R4R7 CHOYP_K1045.2.2 m.61378 sp PHF24_PONAB 29.156 391 244 12 10 376 13 394 5.44E-41 152 PHF24_PONAB reviewed PHD finger protein 24 PHF24 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 400 0 GO:0046872 0 0 0 PF16744; Q80V70 CHOYP_MEGF6.29.59 m.39725 sp MEGF6_MOUSE 34.417 369 189 16 144 481 600 946 5.44E-38 152 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q98943 CHOYP_LOC100892193.2.5 m.28130 sp CASP2_CHICK 29.397 398 236 11 40 410 40 419 5.44E-39 148 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9DFQ7 CHOYP_BRAFLDRAFT_273508.1.4 m.5528 sp RL24_GILMI 68.75 160 43 2 1 156 1 157 5.44E-70 211 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9DFQ7 CHOYP_RL13.1.4 m.15673 sp RL24_GILMI 68.75 160 43 2 1 156 1 157 5.44E-70 211 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9QXW2 CHOYP_LOC100652284.1.1 m.63342 sp FBXW5_MOUSE 30.928 194 132 1 11 202 9 202 5.44E-20 97.4 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; F7H9X2 CHOYP_SMP_039300.1.1 m.1202 sp TRIM2_CALJA 27.273 330 186 5 59 381 12 294 5.45E-31 132 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; H2MTR9 CHOYP_LOC100367423.1.1 m.23397 sp ADIP_ORYLA 32.008 528 295 11 66 562 50 544 5.45E-61 216 ADIP_ORYLA reviewed Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain-interacting protein) (SSX2-interacting protein) ssx2ip Oryzias latipes (Japanese rice fish) (Japanese killifish) 583 cell adhesion [GO:0007155]; determination of left/right symmetry [GO:0007368] GO:0005737; GO:0005813; GO:0005874; GO:0005912; GO:0007155; GO:0007368; GO:0036064 0 0 0 PF11559; O70277 CHOYP_BRAFLDRAFT_87336.3.9 m.20541 sp TRIM3_RAT 25.984 127 87 3 73 195 620 743 5.45E-07 53.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O95817 CHOYP_LOC100186360.1.2 m.50759 sp BAG3_HUMAN 55.882 34 15 0 7 40 21 54 5.45E-06 52.4 BAG3_HUMAN reviewed BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) 575 brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cellular response to heat [GO:1900034]; spinal cord development [GO:0021510] GO:0000774; GO:0005737; GO:0005829; GO:0005886; GO:0005913; GO:0006457; GO:0007420; GO:0008625; GO:0010664; GO:0021510; GO:0030018; GO:0043005; GO:0043066; GO:0050821; GO:0071260; GO:0097192; GO:0098641; GO:1900034 0 0 0 PF02179;PF00397; P36406 CHOYP_LOC100374741.39.83 m.34850 sp TRI23_HUMAN 22.605 261 168 9 1 234 122 375 5.45E-07 55.5 TRI23_HUMAN reviewed E3 ubiquitin-protein ligase TRIM23 (EC 6.3.2.-) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23) TRIM23 ARD1 ARFD1 RNF46 Homo sapiens (Human) 574 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264]; viral process [GO:0016032] GO:0000139; GO:0003924; GO:0004842; GO:0005525; GO:0005634; GO:0005765; GO:0007264; GO:0008047; GO:0008270; GO:0016032; GO:0016567; GO:0016874; GO:0019003; GO:0042802; GO:0070062 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF14634; P41095 CHOYP_BRAFLDRAFT_127105.1.1 m.21928 sp RLA0_ORYSJ 64.516 93 29 2 10 99 228 319 5.45E-23 93.2 RLA0_ORYSJ reviewed 60S acidic ribosomal protein P0 Os08g0130500 LOC_Os08g03640 P0582D05.130-1 Oryza sativa subsp. japonica (Rice) 319 cytoplasmic translation [GO:0002181]; ribosome biogenesis [GO:0042254] GO:0002181; GO:0003735; GO:0022625; GO:0030687; GO:0042254; GO:0070180 0 0 0 PF00466; Q10980 CHOYP_LOC100010332.1.1 m.55950 sp FUT1_RAT 30.435 276 171 11 55 316 83 351 5.45E-32 125 FUT1_RAT reviewed "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha 1,2-fucosyltransferase A) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" Fut1 Fta Rattus norvegicus (Rat) 376 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q18120 CHOYP_AAEL_AAEL004664.1.1 m.184 sp TWK18_CAEEL 25.75 400 178 11 63 450 8 300 5.45E-28 120 TWK18_CAEEL reviewed TWiK family of potassium channels protein 18 twk-18 C24A3.6 Caenorhabditis elegans 461 locomotion [GO:0040011]; muscle contraction [GO:0006936]; potassium ion transport [GO:0006813]; stabilization of membrane potential [GO:0030322] GO:0005887; GO:0006813; GO:0006936; GO:0015271; GO:0016020; GO:0022841; GO:0030322; GO:0040011 0 0 0 PF07885; Q29M42 CHOYP_BRAFLDRAFT_107506.1.1 m.15759 sp C2D1_DROPS 69.118 68 21 0 43 110 744 811 5.45E-27 111 C2D1_DROPS reviewed Coiled-coil and C2 domain-containing protein 1-like GA18377 Drosophila pseudoobscura pseudoobscura (Fruit fly) 814 0 0 0 0 0 PF00168; Q32NG5 CHOYP_GTR12.1.1 m.64326 sp GTR12_XENLA 42.334 574 292 13 53 602 25 583 5.45E-139 420 GTR12_XENLA reviewed "Solute carrier family 2, facilitated glucose transporter member 12 (Glucose transporter type 12) (GLUT-12)" slc2a12 glut12 Xenopus laevis (African clawed frog) 588 carbohydrate transport [GO:0008643] GO:0008643; GO:0012505; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q32PH2 CHOYP_LOC592624.1.1 m.45639 sp TM143_BOVIN 30.89 382 226 12 117 488 55 408 5.45E-39 151 TM143_BOVIN reviewed Transmembrane protein 143 TMEM143 Bos taurus (Bovine) 457 0 GO:0005739; GO:0016021 0 0 0 PF12576; Q3KPT0 CHOYP_BRAFLDRAFT_117200.1.2 m.56933 sp CC169_XENLA 46.535 101 49 2 2 100 9 106 5.45E-20 84.3 CC169_XENLA reviewed Coiled-coil domain-containing protein 169 ccdc169 Xenopus laevis (African clawed frog) 214 0 0 0 0 0 PF15372; Q7Z6J2 CHOYP_LOC655596.1.1 m.43632 sp GRASP_HUMAN 38.462 91 55 1 38 128 89 178 5.45E-13 68.2 GRASP_HUMAN reviewed General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) GRASP Homo sapiens (Human) 395 protein localization [GO:0008104]; signal transduction [GO:0007165] GO:0007165; GO:0008104; GO:0030054; GO:0045211; GO:0048471 0 0 0 PF00595; Q8BK48 CHOYP_SI_CH211-93F2.1.2.4 m.25248 sp EST2E_MOUSE 33.938 551 311 16 582 1115 33 547 5.45E-86 293 EST2E_MOUSE reviewed Pyrethroid hydrolase Ces2e (EC 3.1.1.88) (carboxylesterase 2E) Ces2e Ces5 Mus musculus (Mouse) 559 0 GO:0005615; GO:0005783; GO:0052689; GO:0102209 0 0 0 PF00135; Q8VCC1 CHOYP_PGDH.3.5 m.36973 sp PGDH_MOUSE 43.621 243 131 2 3 239 4 246 5.45E-68 214 PGDH_MOUSE reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) Hpgd Pgdh1 Mus musculus (Mouse) 269 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005654; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070062; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q8WW62 CHOYP_ISCW_ISCW011849.2.2 m.29780 sp TMED6_HUMAN 27.638 199 140 2 40 234 41 239 5.45E-22 93.6 TMED6_HUMAN reviewed Transmembrane emp24 domain-containing protein 6 (p24 family protein gamma-5) (p24gamma5) TMED6 UNQ9146/PRO34237 Homo sapiens (Human) 240 transport [GO:0006810] GO:0005789; GO:0006810; GO:0016021 0 0 0 PF01105; Q92673 CHOYP_SORL.2.3 m.18782 sp SORL_HUMAN 34.948 289 154 8 1 274 1 270 5.45E-40 154 SORL_HUMAN reviewed Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) 2214 cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of beta-amyloid formation [GO:1902430]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein oligomerization [GO:0032460]; negative regulation of tau-protein kinase activity [GO:1902948]; positive regulation of choline O-acetyltransferase activity [GO:1902771]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to Golgi [GO:0000042]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of smooth muscle cell migration [GO:0014910] GO:0000042; GO:0001540; GO:0004888; GO:0005615; GO:0005641; GO:0005768; GO:0005769; GO:0005783; GO:0005794; GO:0005802; GO:0005887; GO:0006605; GO:0006622; GO:0006869; GO:0006892; GO:0006898; GO:0008203; GO:0014910; GO:0016020; GO:0030169; GO:0030306; GO:0031985; GO:0032091; GO:0032460; GO:0034362; GO:0043407; GO:0045053; GO:0045732; GO:0050768; GO:0051604; GO:0055037; GO:0070062; GO:0070863; GO:1901215; GO:1902430; GO:1902771; GO:1902948; GO:1902953; GO:1902955; GO:1902960; GO:1902963; GO:1902966; GO:1902997; GO:2001137 0 0 0 PF00041;PF00057;PF00058;PF15902;PF15901; Q96DM1 CHOYP_LOC100877109.1.1 m.37087 sp PGBD4_HUMAN 33.499 403 242 11 1 390 155 544 5.45E-47 172 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9GZR7 CHOYP_DDX24.1.1 m.6330 sp DDX24_HUMAN 46.958 641 304 9 223 840 191 818 5.45E-179 541 DDX24_HUMAN reviewed ATP-dependent RNA helicase DDX24 (EC 3.6.4.13) (DEAD box protein 24) DDX24 Homo sapiens (Human) 859 RNA metabolic process [GO:0016070]; RNA secondary structure unwinding [GO:0010501] GO:0003724; GO:0004004; GO:0005524; GO:0005730; GO:0010501; GO:0016020; GO:0016070; GO:0044822 0 0 0 PF00270;PF00271; Q9P2K2 CHOYP_BRAFLDRAFT_78229.1.1 m.52210 sp TXD16_HUMAN 25.065 770 519 22 55 816 46 765 5.45E-55 208 TXD16_HUMAN reviewed Thioredoxin domain-containing protein 16 TXNDC16 KIAA1344 Homo sapiens (Human) 825 cell redox homeostasis [GO:0045454] GO:0005788; GO:0045454; GO:0070062 0 0 0 PF00085; A4IF63 CHOYP_LOC100213038.1.1 m.60491 sp TRIM2_BOVIN 22.814 263 153 11 346 583 457 694 5.46E-08 59.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6BM72 CHOYP_DGRI_GH15511.1.1 m.52354 sp MEG11_HUMAN 37.5 240 125 10 193 420 513 739 5.46E-30 127 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; A8MPX8 CHOYP_LOC100374333.2.2 m.65801 sp PP2D1_HUMAN 30.154 650 347 19 61 692 63 623 5.46E-68 238 PP2D1_HUMAN reviewed Protein phosphatase 2C-like domain-containing protein 1 PP2D1 C3orf48 Homo sapiens (Human) 630 0 GO:0004722 0 0 0 PF00481; D3YXG0 CHOYP_TSP2.2.2 m.58235 sp HMCN1_MOUSE 52.991 117 55 0 158 274 4527 4643 5.46E-37 144 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O75382 CHOYP_BRAFLDRAFT_69798.5.22 m.32588 sp TRIM3_HUMAN 26.829 123 87 2 19 139 622 743 5.46E-11 63.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P27085 CHOYP_RS26.14.15 m.57342 sp RS26_OCTVU 86.087 115 14 1 22 134 1 115 5.46E-68 204 RS26_OCTVU reviewed 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) 127 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01283; P92176 CHOYP_ACT2.3.3 m.41138 sp ACT2_LUMTE 98.305 177 3 0 1 177 1 177 5.46E-129 370 ACT2_LUMTE reviewed Actin-2 ACT2 Lumbricus terrestris (Common earthworm) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q14162 CHOYP_SCARF1.5.7 m.37822 sp SREC_HUMAN 34.615 78 45 3 23 98 307 380 5.46E-07 53.5 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q3TDN0 CHOYP_LOC100372582.1.2 m.8557 sp DISP1_MOUSE 25.355 493 292 14 684 1162 716 1146 5.46E-34 146 DISP1_MOUSE reviewed Protein dispatched homolog 1 (Mdispa) Disp1 Disp Dispa Icb Icbins Mus musculus (Mouse) 1521 determination of left/right symmetry [GO:0007368]; diaphragm development [GO:0060539]; dorsal/ventral pattern formation [GO:0009953]; embryonic pattern specification [GO:0009880]; patched ligand maturation [GO:0007225]; pattern specification process [GO:0007389]; peptide transport [GO:0015833]; smoothened signaling pathway [GO:0007224] GO:0007224; GO:0007225; GO:0007368; GO:0007389; GO:0009880; GO:0009953; GO:0015197; GO:0015833; GO:0016021; GO:0060539 0 0 0 PF02460; Q4UMH6 CHOYP_ANK2.5.8 m.51712 sp Y381_RICFE 27.551 392 211 11 334 668 642 1017 5.46E-22 105 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q502M6 CHOYP_ANR29.1.2 m.41304 sp ANR29_DANRE 41.848 184 107 0 2 185 45 228 5.46E-42 145 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q54TR1 CHOYP_ACSL1.1.1 m.686 sp CFAD_DICDI 34.979 486 299 10 1 479 52 527 5.46E-88 281 CFAD_DICDI reviewed Counting factor associated protein D cfaD DDB_G0281605 Dictyostelium discoideum (Slime mold) 531 negative regulation of asexual reproduction [GO:1903665]; positive regulation of chemorepellent activity [GO:1903669]; protein localization to plasma membrane [GO:0072659]; sorocarp morphogenesis [GO:0031288]; sporulation resulting in formation of a cellular spore [GO:0030435] GO:0005576; GO:0005615; GO:0005764; GO:0030435; GO:0031288; GO:0031410; GO:0072659; GO:1903665; GO:1903669 0 0 0 PF08246;PF00112; Q64512 CHOYP_LOC100679475.1.1 m.41103 sp PTN13_MOUSE 42.52 127 68 3 1 125 2252 2375 5.46E-29 115 PTN13_MOUSE reviewed Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (PTP36) (Protein tyrosine phosphatase DPZPTP) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) Ptpn13 Ptp14 Mus musculus (Mouse) 2453 peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066] GO:0004725; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0006470; GO:0014066; GO:0030027; GO:0030496; GO:0035335; GO:0036312; GO:0070062 0 0 0 PF09380;PF00373;PF09379;PF00595;PF00102; Q6ZRF8 CHOYP_LOC100370588.5.19 m.21261 sp RN207_HUMAN 24.88 209 134 9 16 218 103 294 5.46E-13 71.6 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8BZH4 CHOYP_PAR15.5.6 m.60634 sp POGZ_MOUSE 30.389 283 161 8 13 269 560 832 5.46E-32 135 POGZ_MOUSE reviewed Pogo transposable element with ZNF domain Pogz Kiaa0461 Mus musculus (Mouse) 1409 cell division [GO:0051301]; kinetochore assembly [GO:0051382]; mitotic sister chromatid cohesion [GO:0007064] GO:0000790; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0007064; GO:0046872; GO:0051301; GO:0051382 0 0 0 PF03184;PF03221; Q8IVI9 CHOYP_AGO1.1.1 m.16550 sp NOSTN_HUMAN 30.04 496 328 7 21 511 14 495 5.46E-66 224 NOSTN_HUMAN reviewed Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) NOSTRIN Homo sapiens (Human) 506 "endocytosis [GO:0006897]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of nitric-oxide synthase activity [GO:0050999]; signal transduction [GO:0007165]" GO:0003677; GO:0005634; GO:0005856; GO:0005886; GO:0006897; GO:0007165; GO:0030666; GO:0045892; GO:0050999 0 0 0 PF00611;PF14604; Q8MJY8 CHOYP_PGDH.4.5 m.65203 sp PGDH_MACFA 41.176 255 145 2 1 251 1 254 5.46E-65 206 PGDH_MACFA reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 266 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q8R3Q6 CHOYP_LOC100554450.1.1 m.66550 sp CCD58_MOUSE 46.847 111 57 1 1 109 31 141 5.46E-32 112 CCD58_MOUSE reviewed Coiled-coil domain-containing protein 58 Ccdc58 Mus musculus (Mouse) 144 0 GO:0005739 0 0 0 PF09774; Q96P65 CHOYP_BRAFLDRAFT_74637.1.1 m.45691 sp QRFPR_HUMAN 34.076 314 179 6 39 334 38 341 5.46E-59 200 QRFPR_HUMAN reviewed Pyroglutamylated RFamide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) QRFPR GPR103 Homo sapiens (Human) 431 cellular response to hormone stimulus [GO:0032870]; G-protein coupled receptor signaling pathway [GO:0007186]; response to peptide [GO:1901652] GO:0004930; GO:0004983; GO:0005886; GO:0005887; GO:0007186; GO:0016021; GO:0032870; GO:0042277; GO:1901652 0 0 0 PF00001; Q9H3N1 CHOYP_BRAFLDRAFT_275793.1.1 m.9519 sp TMX1_HUMAN 42.105 190 105 1 42 231 34 218 5.46E-63 202 TMX1_HUMAN reviewed Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) TMX1 TMX TXNDC TXNDC1 PSEC0085 UNQ235/PRO268 Homo sapiens (Human) 280 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005730; GO:0005783; GO:0005789; GO:0006457; GO:0015036; GO:0016021; GO:0034976; GO:0045454 0 0 0 PF00085; A4IIK1 CHOYP_LOC100370194.1.1 m.52469 sp MFHA1_XENTR 40.351 228 122 3 34 260 173 387 5.47E-39 148 MFHA1_XENTR reviewed Malignant fibrous histiocytoma-amplified sequence 1 homolog mfhas1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 997 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF16095;PF13855;PF08477; D2GXS7 CHOYP_contig_045767 m.53362 sp TRIM2_AILME 24.88 209 132 7 67 262 492 688 5.47E-10 62.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_71754.2.3 m.42047 sp TRIM3_RAT 26.984 126 85 3 36 159 622 742 5.47E-08 55.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC100120322.1.3 m.1078 sp TRIM3_RAT 23.485 264 178 7 317 563 488 744 5.47E-11 68.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P04323 CHOYP_T184C.2.2 m.36660 sp POL3_DROME 25.401 374 226 15 22 380 289 624 5.47E-11 69.3 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P12970 CHOYP_LOC100707299.1.1 m.15099 sp RL7A_MOUSE 72.727 66 18 0 33 98 23 88 5.47E-30 110 RL7A_MOUSE reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) Rpl7a Surf-3 Surf3 Mus musculus (Mouse) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0006412; GO:0016020; GO:0022625; GO:0042788; GO:0044822; GO:0070062 0 0 0 PF01248; P16157 CHOYP_TVAG_020440.16.21 m.47704 sp ANK1_HUMAN 34.336 399 233 1 2 371 97 495 5.47E-66 230 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_168010.15.45 m.35998 sp ANK1_HUMAN 31.769 554 372 2 208 755 174 727 5.47E-86 301 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18489 CHOYP_LOC100699603.1.2 m.40687 sp SYB_DROME 32.558 86 58 0 61 146 41 126 5.47E-10 58.5 SYB_DROME reviewed Synaptobrevin Syb CG12210 Drosophila melanogaster (Fruit fly) 152 "exocytosis [GO:0006887]; lumen formation, open tracheal system [GO:0035149]; neurotransmitter secretion [GO:0007269]; synaptic vesicle docking [GO:0016081]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192]" GO:0000149; GO:0005484; GO:0005886; GO:0006887; GO:0006906; GO:0007269; GO:0008021; GO:0016021; GO:0016081; GO:0016192; GO:0030054; GO:0030672; GO:0035149; GO:0043005 0 0 0 PF00957; P26779 CHOYP_LOC100208544.1.1 m.54499 sp SAP_BOVIN 30.159 441 243 13 295 673 51 488 5.47E-46 174 SAP_BOVIN reviewed Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)] PSAP Bos taurus (Bovine) 525 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; glycosphingolipid metabolic process [GO:0006687]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216] GO:0001664; GO:0005615; GO:0005737; GO:0005764; GO:0006687; GO:0007193; GO:0008047; GO:0019216; GO:0060736; GO:0060742 0 0 0 PF02199;PF05184;PF03489; P33274 CHOYP_BRAFLDRAFT_61250.14.14 m.65552 sp CP4F1_RAT 38.587 184 102 3 36 211 130 310 5.47E-37 137 CP4F1_RAT reviewed Cytochrome P450 4F1 (EC 1.14.14.1) (CYPIVF1) (Cytochrome P450-A3) Cyp4f1 Cyp4f-1 Cyp4f2 Rattus norvegicus (Rat) 524 arachidonic acid metabolic process [GO:0019369]; icosanoid metabolic process [GO:0006690]; response to toxic substance [GO:0009636] GO:0005506; GO:0005789; GO:0006690; GO:0008391; GO:0009636; GO:0019369; GO:0020037; GO:0031090; GO:0043231; GO:0050544; GO:0070330 0 0 0 PF00067; P35331 CHOYP_LOC100707588.1.1 m.3834 sp NRCAM_CHICK 31.463 410 245 12 23 418 39 426 5.47E-51 188 NRCAM_CHICK reviewed Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (gBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) 0 Gallus gallus (Chicken) 1284 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; clustering of voltage-gated sodium channels [GO:0045162]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron cell-cell adhesion [GO:0007158] GO:0005886; GO:0005887; GO:0005911; GO:0007156; GO:0007158; GO:0016338; GO:0016339; GO:0030246; GO:0030247; GO:0030506; GO:0045162; GO:0046982; GO:0050839 0 0 0 PF13882;PF00041;PF07679; P48508 CHOYP_BRAFLDRAFT_113892.1.1 m.44055 sp GSH0_RAT 37.5 256 159 1 12 266 16 271 5.47E-65 207 GSH0_RAT reviewed Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit) Gclm Glclr Rattus norvegicus (Rat) 274 aging [GO:0007568]; apoptotic mitochondrial changes [GO:0008637]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cellular response to thyroxine stimulus [GO:0097069]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; hepatic stellate cell activation [GO:0035733]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of glutamate-cysteine ligase activity [GO:0035229]; regulation of blood vessel size [GO:0050880]; regulation of mitochondrial depolarization [GO:0051900]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to human chorionic gonadotropin [GO:0044752]; response to nitrosative stress [GO:0051409]; response to nutrient [GO:0007584]; response to oxidative stress [GO:0006979] GO:0004357; GO:0006534; GO:0006536; GO:0006750; GO:0006979; GO:0007568; GO:0007584; GO:0008637; GO:0014823; GO:0017109; GO:0030234; GO:0035226; GO:0035229; GO:0035729; GO:0035733; GO:0042493; GO:0043524; GO:0044344; GO:0044752; GO:0046982; GO:0050880; GO:0051409; GO:0051900; GO:0071333; GO:0071372; GO:0097069; GO:2001237 PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. 0 0 PF00248; P50174 CHOYP_NEMVEDRAFT_V1G169195.1.1 m.2476 sp THIL_RHIME 60.651 338 131 1 17 354 6 341 5.47E-142 417 THIL_RHIME reviewed Acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) phbA R03262 SMc03879 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) 393 poly-hydroxybutyrate biosynthetic process [GO:0042619] GO:0003985; GO:0005737; GO:0042619 PATHWAY: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3. 0 0 PF02803;PF00108; Q08174 CHOYP_LOC101157079.1.2 m.6704 sp PCDH1_HUMAN 32.01 781 488 19 27 785 56 815 5.47E-109 365 PCDH1_HUMAN reviewed Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) 1060 cell-cell signaling [GO:0007267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] GO:0005509; GO:0005886; GO:0005887; GO:0005911; GO:0007156; GO:0007267; GO:0007399 0 0 0 PF00028;PF08266;PF08374; Q5ZLN7 CHOYP_FAM122B.1.1 m.7361 sp F122A_CHICK 38.934 244 105 15 5 236 3 214 5.47E-16 80.5 F122A_CHICK reviewed Protein FAM122A FAM122A RCJMB04_5g5 Gallus gallus (Chicken) 284 0 0 0 0 0 0 Q62283 CHOYP_BRAFLDRAFT_96598.1.1 m.54770 sp TSN7_MOUSE 27.757 263 152 10 9 270 12 237 5.47E-17 82 TSN7_MOUSE reviewed Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (PE31) (TALLA homolog) (Transmembrane 4 superfamily member 2) (CD antigen CD231) Tspan7 Mxs1 Tm4sf2 Mus musculus (Mouse) 249 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q96WV6 CHOYP_contig_027437 m.31153 sp YHU2_SCHPO 32.108 408 226 11 1 390 2177 2551 5.47E-21 99 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q9D773 CHOYP_ISCW_ISCW005878.1.1 m.39374 sp RM02_MOUSE 38.699 292 161 5 1 277 1 289 5.47E-52 176 RM02_MOUSE reviewed "39S ribosomal protein L2, mitochondrial (L2mt) (MRP-L2)" Mrpl2 Mus musculus (Mouse) 306 mitochondrial translation [GO:0032543]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005762; GO:0006412; GO:0016740; GO:0032543; GO:0044822 0 0 0 PF00181;PF03947; Q9GNQ1 CHOYP_LPS18.1.1 m.46990 sp LPS18_LEHMA 49.02 102 41 5 1 97 1 96 5.47E-21 84.3 LPS18_LEHMA reviewed 18 kDa learning-associated protein of slug LAPS18 Lehmannia marginata (Tree slug) (Limax marginatus) 121 learning or memory [GO:0007611]; long-term memory [GO:0007616] GO:0005576; GO:0005737; GO:0007611; GO:0007616 0 0 0 PF10169; Q9JI92 CHOYP_KDM1A.1.1 m.60231 sp SDCB1_RAT 55.116 303 125 3 4 300 3 300 5.47E-120 349 SDCB1_RAT reviewed Syntenin-1 (Syndecan-binding protein 1) Sdcbp Rattus norvegicus (Rat) 300 actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor internalization [GO:0002091]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; Ras protein signal transduction [GO:0007265]; regulation of mitotic cell cycle [GO:0007346] GO:0001948; GO:0002091; GO:0005137; GO:0005634; GO:0005789; GO:0005829; GO:0005856; GO:0005886; GO:0005895; GO:0005925; GO:0007265; GO:0007268; GO:0007346; GO:0008022; GO:0008284; GO:0010718; GO:0010862; GO:0019838; GO:0030036; GO:0030307; GO:0030335; GO:0030511; GO:0032435; GO:0042043; GO:0042470; GO:0042803; GO:0045121; GO:0045545; GO:0046875; GO:0046982; GO:0050839; GO:0070062; GO:0072562; GO:1903543; GO:1903553 0 0 0 PF00595; Q9LQU4 CHOYP_LOC100891563.1.2 m.27443 sp PCR2_ARATH 35.922 103 59 2 3 98 14 116 5.47E-11 58.9 PCR2_ARATH reviewed Protein PLANT CADMIUM RESISTANCE 2 (AtPCR2) PCR2 At1g14870 F10B6.27 Arabidopsis thaliana (Mouse-ear cress) 152 response to oxidative stress [GO:0006979] GO:0005886; GO:0006979; GO:0016021 0 0 0 PF04749; Q9LQU4 CHOYP_LOC100891563.2.2 m.63492 sp PCR2_ARATH 35.922 103 59 2 3 98 14 116 5.47E-11 58.9 PCR2_ARATH reviewed Protein PLANT CADMIUM RESISTANCE 2 (AtPCR2) PCR2 At1g14870 F10B6.27 Arabidopsis thaliana (Mouse-ear cress) 152 response to oxidative stress [GO:0006979] GO:0005886; GO:0006979; GO:0016021 0 0 0 PF04749; Q9NTM9 CHOYP_CUTC.1.1 m.50181 sp CUTC_HUMAN 59.916 237 95 0 1 237 28 264 5.47E-99 292 CUTC_HUMAN reviewed Copper homeostasis protein cutC homolog CUTC CGI-32 Homo sapiens (Human) 273 copper ion homeostasis [GO:0055070]; copper ion transport [GO:0006825]; protein tetramerization [GO:0051262] GO:0005507; GO:0005634; GO:0005730; GO:0005737; GO:0006825; GO:0051262; GO:0055070 0 0 0 PF03932; Q9UIF8 CHOYP_BRAFLDRAFT_122791.5.6 m.51053 sp BAZ2B_HUMAN 39.469 565 286 12 576 1117 731 1262 5.47E-104 377 BAZ2B_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 2B (hWALp4) BAZ2B KIAA1476 Homo sapiens (Human) 2168 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF00439;PF02791;PF01429;PF00628;PF15613; A8E5V9 CHOYP_TMEM173.5.5 m.65150 sp STING_XENTR 26.108 203 123 7 170 362 136 321 5.48E-09 62 STING_XENTR reviewed Stimulator of interferon genes protein (STING) (Transmembrane protein 173) tmem173 sting Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 329 activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of type I interferon production [GO:0032481] GO:0002218; GO:0005741; GO:0005789; GO:0005886; GO:0006915; GO:0016021; GO:0032481; GO:0032608; GO:0035438; GO:0042803; GO:0045087; GO:0048471; GO:0051607; GO:0061507 0 0 0 PF15009; O31463 CHOYP_BRAFLDRAFT_98591.1.1 m.39948 sp HMT_BACSU 43.03 165 92 2 42 205 143 306 5.48E-38 136 HMT_BACSU reviewed Homocysteine S-methyltransferase YbgG (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase) ybgG BSU02410 Bacillus subtilis (strain 168) 315 methionine biosynthetic process [GO:0009086] GO:0008168; GO:0009086; GO:0046872 0 0 0 PF02574; O43301 CHOYP_BRAFLDRAFT_208197.12.21 m.49142 sp HS12A_HUMAN 30.251 638 350 19 230 792 57 674 5.48E-78 268 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P13846 CHOYP_LOC100485517.2.2 m.57428 sp DPOL_HHBV 31.138 167 104 6 82 244 448 607 5.48E-09 62 DPOL_HHBV reviewed Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Heron hepatitis B virus (HHBV) 788 DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006260; GO:0046872 0 0 0 PF00336;PF00242;PF00078; P98158 CHOYP_LDLR.3.7 m.15783 sp LRP2_RAT 40.838 191 100 5 46 224 3553 3742 5.48E-31 123 LRP2_RAT reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) Lrp2 Rattus norvegicus (Rat) 4660 aging [GO:0007568]; endosomal transport [GO:0016197]; hemoglobin import [GO:0020028]; hormone secretion [GO:0046879]; lipoprotein transport [GO:0042953]; negative regulation of endopeptidase activity [GO:0010951]; organ regeneration [GO:0031100]; receptor-mediated endocytosis [GO:0006898]; response to drug [GO:0042493]; response to retinoic acid [GO:0032526]; response to vitamin D [GO:0033280]; response to X-ray [GO:0010165]; transcytosis [GO:0045056]; vitamin metabolic process [GO:0006766] GO:0004872; GO:0005509; GO:0005615; GO:0005737; GO:0005768; GO:0005903; GO:0005905; GO:0006766; GO:0006898; GO:0007568; GO:0010165; GO:0010951; GO:0016020; GO:0016021; GO:0016197; GO:0016324; GO:0020028; GO:0030165; GO:0030492; GO:0031100; GO:0031526; GO:0032403; GO:0032526; GO:0033280; GO:0042493; GO:0042562; GO:0042953; GO:0043234; GO:0045056; GO:0045121; GO:0046879; GO:0050750 0 0 0 PF12662;PF07645;PF00057;PF00058; Q33E94 CHOYP_NEMVEDRAFT_V1G122918.1.1 m.47823 sp RFX4_HUMAN 29.009 424 289 6 104 523 59 474 5.48E-58 208 RFX4_HUMAN reviewed Transcription factor RFX4 (Regulatory factor X 4) (Testis development protein NYD-SP10) RFX4 Homo sapiens (Human) 735 cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; dorsal spinal cord development [GO:0021516]; midbrain development [GO:0030901]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of protein processing [GO:0070613]; telencephalon development [GO:0021537] GO:0000978; GO:0001077; GO:0003682; GO:0005634; GO:0021516; GO:0021537; GO:0021696; GO:0021914; GO:0030901; GO:0042384; GO:0045944; GO:0070613 0 0 0 PF02257; Q53G44 CHOYP_LOC101165968.2.7 m.18121 sp IF44L_HUMAN 40.996 261 151 2 64 322 176 435 5.48E-55 189 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5EAR5 CHOYP_BRAFLDRAFT_274539.2.3 m.26932 sp TRPT1_DANRE 50 210 98 4 190 395 18 224 5.48E-59 202 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q7Z449 CHOYP_BRAFLDRAFT_271642.1.1 m.32364 sp CP2U1_HUMAN 32.692 260 169 4 16 270 286 544 5.48E-47 167 CP2U1_HUMAN reviewed Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Homo sapiens (Human) 544 omega-hydroxylase P450 pathway [GO:0097267] GO:0004497; GO:0005506; GO:0005789; GO:0008395; GO:0016021; GO:0019825; GO:0020037; GO:0031090; GO:0070330; GO:0097267 0 0 0 PF00067; Q96ME1 CHOYP_BRAFLDRAFT_287444.1.5 m.679 sp FXL18_HUMAN 31.412 347 196 8 364 701 365 678 5.48E-35 146 FXL18_HUMAN reviewed F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18) FBXL18 FBL18 Homo sapiens (Human) 805 0 0 0 0 0 PF00646; Q9I931 CHOYP_BRAFLDRAFT_125849.2.2 m.50710 sp FUCL1_ANGJA 33.333 117 66 6 90 195 56 171 5.48E-08 53.9 FUCL1_ANGJA reviewed Fucolectin-1 0 Anguilla japonica (Japanese eel) 178 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9UIL4 CHOYP_BRAFLDRAFT_84054.1.2 m.8523 sp KIF25_HUMAN 46.814 408 162 6 202 604 18 375 5.48E-111 341 KIF25_HUMAN reviewed Kinesin-like protein KIF25 (Kinesin-like protein 3) KIF25 KNSL3 Homo sapiens (Human) 384 microtubule-based movement [GO:0007018]; mitotic sister chromatid segregation [GO:0000070]; negative regulation of autophagy [GO:0010507]; organelle organization [GO:0006996] GO:0000070; GO:0003777; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0006996; GO:0007018; GO:0010507; GO:0016887 0 0 0 PF00225; A5PLK6 CHOYP_LOC100376370.2.2 m.50402 sp RGSL_HUMAN 24.096 415 244 10 706 1090 606 979 5.49E-26 120 RGSL_HUMAN reviewed Regulator of G-protein signaling protein-like RGSL1 RGSL RGSL2 Homo sapiens (Human) 1076 0 GO:0005096; GO:0005737; GO:0005886; GO:0016021 0 0 0 PF00615; O15553 CHOYP_ZGC_136767.1.2 m.3222 sp MEFV_HUMAN 25.926 162 94 3 38 196 373 511 5.49E-07 53.1 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; P20825 CHOYP_LOC754648.2.3 m.14124 sp POL2_DROME 31.5 200 93 4 316 479 413 604 5.49E-15 81.6 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P24140 CHOYP_LOC100368253.1.1 m.13031 sp GPT_CRIGR 60.298 403 159 1 5 407 6 407 5.49E-175 497 GPT_CRIGR reviewed UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase) DPAGT1 DPAGT2 GNPTA GTR2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 408 dolichol biosynthetic process [GO:0019408]; protein glycosylation [GO:0006486]; protein oligomerization [GO:0051259] GO:0003975; GO:0005789; GO:0006486; GO:0008963; GO:0016021; GO:0016757; GO:0019408; GO:0030176; GO:0051259 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00953; P27166 CHOYP_CALM.10.50 m.22172 sp CALM_STYLE 51.37 146 71 0 1 146 1 146 5.49E-50 159 CALM_STYLE reviewed Calmodulin (CaM) 0 Stylonychia lemnae (Ciliate) 149 0 GO:0005509 0 0 0 PF13499; P27166 CHOYP_CALM.40.50 m.54954 sp CALM_STYLE 51.37 146 71 0 1 146 1 146 5.49E-50 159 CALM_STYLE reviewed Calmodulin (CaM) 0 Stylonychia lemnae (Ciliate) 149 0 GO:0005509 0 0 0 PF13499; P59222 CHOYP_LOC100555258.1.3 m.24861 sp SREC2_MOUSE 37.222 180 104 7 1 180 227 397 5.49E-24 104 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P86854 CHOYP_MRC2.1.1 m.29330 sp PLCL_MYTGA 31.613 155 93 5 12 155 4 156 5.49E-20 84.3 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q04073 CHOYP_P3A2.2.3 m.13667 sp P3A2_STRPU 54.197 417 128 11 26 399 2 398 5.49E-138 407 P3A2_STRPU reviewed DNA-binding protein P3A2 0 Strongylocentrotus purpuratus (Purple sea urchin) 459 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF10492;PF10491; Q05AQ8 CHOYP_ZN703.1.1 m.50334 sp ZN503_XENTR 33.908 522 268 22 6 495 56 532 5.49E-33 135 ZN503_XENTR reviewed Zinc finger protein 503 znf503 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 541 "embryonic camera-type eye morphogenesis [GO:0048596]; hindbrain development [GO:0030902]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0030902; GO:0046872; GO:0048596 0 0 0 PF12402; Q24K15 CHOYP_ANGP4.2.7 m.22752 sp ANGP4_BOVIN 39.189 222 127 5 61 279 261 477 5.49E-53 182 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q29NV5 CHOYP_RM10.1.2 m.26850 sp RM10_DROPS 30.851 188 120 4 55 241 52 230 5.49E-24 100 RM10_DROPS reviewed "39S ribosomal protein L10, mitochondrial (L10mt) (MRP-L10)" mRpL10 GA11028 Drosophila pseudoobscura pseudoobscura (Fruit fly) 253 ribosome biogenesis [GO:0042254]; translation [GO:0006412] GO:0003735; GO:0005762; GO:0006412; GO:0030529; GO:0042254 0 0 0 PF00466; Q3T0F5 CHOYP_RAB7A.1.2 m.23790 sp RAB7A_BOVIN 87.923 207 23 2 1 205 1 207 5.49E-133 374 RAB7A_BOVIN reviewed Ras-related protein Rab-7a RAB7A RAB7 Bos taurus (Bovine) 207 early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; lipophagy [GO:0061724]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000421; GO:0005525; GO:0005764; GO:0005770; GO:0005774; GO:0005811; GO:0005829; GO:0007264; GO:0008333; GO:0015031; GO:0030670; GO:0031902; GO:0032419; GO:0033162; GO:0045022; GO:0045335; GO:0061724; GO:0090383; GO:0090385 0 0 0 PF00071; Q3T0F5 CHOYP_RAB7A.2.2 m.49927 sp RAB7A_BOVIN 87.923 207 23 2 1 205 1 207 5.49E-133 374 RAB7A_BOVIN reviewed Ras-related protein Rab-7a RAB7A RAB7 Bos taurus (Bovine) 207 early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; lipophagy [GO:0061724]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000421; GO:0005525; GO:0005764; GO:0005770; GO:0005774; GO:0005811; GO:0005829; GO:0007264; GO:0008333; GO:0015031; GO:0030670; GO:0031902; GO:0032419; GO:0033162; GO:0045022; GO:0045335; GO:0061724; GO:0090383; GO:0090385 0 0 0 PF00071; Q5ZJL9 CHOYP_SAMHD1.1.1 m.39619 sp SAMH1_CHICK 49.351 308 136 5 4 296 107 409 5.49E-92 288 SAMH1_CHICK reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) 614 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966; Q6R7J1 CHOYP_Y028.1.1 m.30883 sp Y033_OSHVF 100 168 0 0 1 168 1 168 5.49E-120 343 Y033_OSHVF reviewed Uncharacterized protein ORF33 ORF33 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 296 0 0 0 0 0 0 Q80UX8 CHOYP_BRAFLDRAFT_75084.1.1 m.25345 sp ABHDD_MOUSE 44.785 326 172 4 22 344 1 321 5.49E-99 299 ABHDD_MOUSE reviewed Protein ABHD13 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 13) (Abhydrolase domain-containing protein 13) Abhd13 Mus musculus (Mouse) 337 0 GO:0016020; GO:0016021; GO:0016787 0 0 0 PF12146; Q86Z23 CHOYP_LOC100371610.2.2 m.45181 sp C1QL4_HUMAN 35.714 140 71 6 24 156 110 237 5.49E-18 81.3 C1QL4_HUMAN reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8BGC4 CHOYP_ZADH2.3.3 m.44891 sp ZADH2_MOUSE 52.778 144 63 3 3 143 26 167 5.49E-43 149 ZADH2_MOUSE reviewed Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-) Zadh2 Mus musculus (Mouse) 377 0 GO:0005739; GO:0005777; GO:0008270; GO:0016491 0 0 0 PF08240;PF00107; Q8MRC9 CHOYP_DPSE_GA25136.1.1 m.66680 sp GALT9_DROME 56.731 104 45 0 1 104 300 403 5.49E-36 131 GALT9_DROME reviewed Putative polypeptide N-acetylgalactosaminyltransferase 9 (pp-GaNTase 9) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9) pgant9 CG30463 Drosophila melanogaster (Fruit fly) 650 multicellular organism reproduction [GO:0032504]; protein O-linked glycosylation [GO:0006493] GO:0000139; GO:0004653; GO:0005794; GO:0005829; GO:0006493; GO:0016021; GO:0030246; GO:0031985; GO:0032504; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q99L04 CHOYP_LOC592990.1.1 m.17663 sp DHRS1_MOUSE 50.755 331 136 6 4 329 5 313 5.49E-111 328 DHRS1_MOUSE reviewed Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) Dhrs1 D14ertd484e Mus musculus (Mouse) 313 0 GO:0005739; GO:0005743; GO:0005783; GO:0016491 0 0 0 PF00106; Q9R186 CHOYP_NAN.1.1 m.32309 sp TRPV6_RAT 29.542 677 395 21 98 762 80 686 5.49E-69 245 TRPV6_RAT reviewed Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) Trpv6 Rattus norvegicus (Rat) 767 calcium ion import [GO:0070509]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; protein homotetramerization [GO:0051289] GO:0005227; GO:0005262; GO:0005886; GO:0005887; GO:0016324; GO:0051289; GO:0070509; GO:0070588; GO:1990035 0 0 0 PF12796;PF00520; D3ZHH1 CHOYP_LOC100893124.1.1 m.4621 sp DLL4_RAT 29.348 460 255 14 33 441 27 467 5.50E-38 153 DLL4_RAT reviewed Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4) Dll4 Rattus norvegicus (Rat) 686 blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac atrium morphogenesis [GO:0003209]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; dorsal aorta morphogenesis [GO:0035912]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; patterning of blood vessels [GO:0001569]; pericardium morphogenesis [GO:0003344]; positive regulation of gene expression [GO:0010628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; T cell differentiation [GO:0030217]; ventral spinal cord interneuron fate commitment [GO:0060579]; ventricular trabecula myocardium morphogenesis [GO:0003222] GO:0000122; GO:0001569; GO:0001974; GO:0003209; GO:0003222; GO:0003344; GO:0005509; GO:0005886; GO:0010628; GO:0016021; GO:0030217; GO:0035912; GO:0035924; GO:0044344; GO:0045746; GO:0045747; GO:0050767; GO:0060579; GO:0061074; GO:0061314; GO:0072554; GO:0090051; GO:1903588; GO:2000179 0 0 0 PF01414;PF00008;PF12661;PF07657; O75592 CHOYP_MYCB2.2.2 m.15321 sp MYCB2_HUMAN 47.651 298 144 5 62 348 4342 4638 5.50E-93 306 MYCB2_HUMAN reviewed E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) 4640 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016020; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF00630;PF08005;PF00415;PF08239;PF13639; P10394 CHOYP_LOC578054.3.7 m.17053 sp POL4_DROME 24.031 129 93 1 5 133 1065 1188 5.50E-06 48.1 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P41436 CHOYP_ADORNPV_GP085.1.1 m.23659 sp IAP_GVCPM 33.766 77 51 0 279 355 102 178 5.50E-07 53.9 IAP_GVCPM reviewed Apoptosis inhibitor IAP IAP Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) 275 0 GO:0008270 0 0 0 PF00653; P56591 CHOYP_CP1A1.1.1 m.7519 sp CP1A1_SHEEP 38.353 498 289 6 8 488 10 506 5.50E-129 387 CP1A1_SHEEP reviewed Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (Cytochrome P450-C) (Cytochrome P4501A1) CYP1A1 Ovis aries (Sheep) 519 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P82186 CHOYP_GUN.2.2 m.46462 sp GUN_MYTED 65.746 181 55 2 23 198 2 180 5.50E-86 254 GUN_MYTED reviewed "Endoglucanase (EC 3.2.1.4) (CMCase) (Cellulase) (Endo-1,4-beta-glucanase)" 0 Mytilus edulis (Blue mussel) 181 cellulose catabolic process [GO:0030245] GO:0008810; GO:0030245 0 0 0 0 Q0VD31 CHOYP_DMOJ_GI15977.1.1 m.55933 sp FBXL4_BOVIN 29.282 181 96 6 32 180 47 227 5.50E-17 84.7 FBXL4_BOVIN reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) FBXL4 Bos taurus (Bovine) 621 0 GO:0005634; GO:0005758 0 0 0 PF00646; Q1LV46 CHOYP_LOC100378195.1.1 m.46024 sp ABHEA_DANRE 43.719 199 103 4 70 266 77 268 5.50E-47 160 ABHEA_DANRE reviewed Protein ABHD14A (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 14A) (Abhydrolase domain-containing protein 14A) abhd14a si:ch211-231a1.1 zgc:85972 Danio rerio (Zebrafish) (Brachydanio rerio) 270 0 GO:0005737; GO:0016021; GO:0016787 0 0 0 PF12697; Q55EH8 CHOYP_LOC101072538.1.1 m.51457 sp ABCGN_DICDI 36.17 423 245 7 14 421 36 448 5.50E-79 261 ABCGN_DICDI reviewed ABC transporter G family member 23 (ABC transporter ABCG.23) abcG23 DDB_G0269026 Dictyostelium discoideum (Slime mold) 701 transport [GO:0006810] GO:0005524; GO:0006810; GO:0016021; GO:0016887 0 0 0 PF00005; Q5BK24 CHOYP_LOC101062314.1.1 m.18494 sp CH076_RAT 34.32 169 108 2 3 170 8 174 5.50E-20 91.7 CH076_RAT reviewed Uncharacterized protein C8orf76 homolog 0 Rattus norvegicus (Rat) 374 0 0 0 0 0 0 Q5EA33 CHOYP_LOC578101.1.1 m.17705 sp ANR49_BOVIN 48.421 190 88 2 20 199 37 226 5.50E-52 173 ANR49_BOVIN reviewed Ankyrin repeat domain-containing protein 49 ANKRD49 Bos taurus (Bovine) 238 "cell differentiation [GO:0030154]; positive regulation of transcription, DNA-templated [GO:0045893]; spermatogenesis [GO:0007283]" GO:0005634; GO:0007283; GO:0030154; GO:0045893 0 0 0 PF00023; Q5R4M2 CHOYP_ULK4.1.3 m.14608 sp ULK4_PONAB 43.252 615 313 10 1 603 1 591 5.50E-162 499 ULK4_PONAB reviewed Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4) ULK4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1275 0 GO:0004674; GO:0005524 0 0 0 PF00069; Q5R9K8 CHOYP_LOC100367381.1.2 m.17575 sp AR2BP_PONAB 62.329 146 55 0 33 178 3 148 5.50E-60 188 AR2BP_PONAB reviewed ADP-ribosylation factor-like protein 2-binding protein (ARF-like 2-binding protein) ARL2BP Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 163 maintenance of protein location in nucleus [GO:0051457]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517] GO:0003713; GO:0005634; GO:0005758; GO:0005813; GO:0005819; GO:0005929; GO:0030496; GO:0042517; GO:0051457 0 0 0 PF11527; Q9CZ57 CHOYP_NSUN4.1.1 m.13670 sp NSUN4_MOUSE 47.718 241 117 3 1 232 139 379 5.50E-68 216 NSUN4_MOUSE reviewed 5-methylcytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) (Sperm head and tail associated protein) Nsun4 Shtap Mus musculus (Mouse) 381 mature ribosome assembly [GO:0042256]; positive regulation of mitochondrial translation [GO:0070131]; rRNA methylation [GO:0031167] GO:0005739; GO:0005762; GO:0008168; GO:0031167; GO:0042256; GO:0070131; GO:0070181 0 0 0 PF01189; Q9I8S2 CHOYP_LOC100691696.1.1 m.66554 sp MCES_XENLA 60.748 107 36 2 1 107 90 190 5.50E-37 132 MCES_XENLA reviewed mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (xCMT1) rnmt Xenopus laevis (African clawed frog) 402 7-methylguanosine mRNA capping [GO:0006370] GO:0003723; GO:0004482; GO:0005634; GO:0005845; GO:0006370 0 0 0 PF03291; Q9UGM3 CHOYP_LOC100636340.3.4 m.44279 sp DMBT1_HUMAN 28.349 1926 1013 64 30 1635 92 1970 5.50E-158 552 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; G5ED84 CHOYP_AGAP_AGAP003823.1.1 m.16648 sp KLHL8_CAEEL 24.845 161 109 4 13 171 72 222 5.51E-07 56.6 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O01404 CHOYP_LOC100866792.1.1 m.3066 sp PHM_DROME 43.45 313 154 13 72 365 56 364 5.51E-76 242 PHM_DROME reviewed Peptidylglycine alpha-hydroxylating monooxygenase (dPHM) (EC 1.14.17.3) Phm CG3832 Drosophila melanogaster (Fruit fly) 365 memory [GO:0007613]; multicellular organism reproduction [GO:0032504]; peptide metabolic process [GO:0006518]; regulation of imaginal disc-derived wing size [GO:0044719]; response to fungus [GO:0009620] GO:0004504; GO:0005507; GO:0005615; GO:0006518; GO:0007613; GO:0009620; GO:0016020; GO:0032504; GO:0044719 0 0 0 PF03712;PF01082; P14133 CHOYP_LOC100198324.4.6 m.60758 sp ASO_CUCSA 27.319 593 305 20 101 658 58 559 5.51E-48 181 ASO_CUCSA reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) 0 Cucumis sativus (Cucumber) 587 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P30602 CHOYP_LOC100907845.1.3 m.9952 sp CHS3_EXODE 26.977 430 226 15 364 713 366 787 5.51E-19 96.7 CHS3_EXODE reviewed Chitin synthase 3 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 3) (Class-III chitin synthase 3) CHS3 Exophiala dermatitidis (Black yeast) (Wangiella dermatitidis) 885 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0071555 0 0 0 PF01644;PF08407; P82251 CHOYP_BAT1.2.4 m.14701 sp BAT1_HUMAN 51.584 442 207 1 3 444 24 458 5.51E-165 477 BAT1_HUMAN reviewed "b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Homo sapiens (Human) 487 amino acid transport [GO:0006865]; L-cystine transport [GO:0015811]; leukocyte migration [GO:0050900]; neutral amino acid transport [GO:0015804]; protein complex assembly [GO:0006461] GO:0005886; GO:0005887; GO:0006461; GO:0006865; GO:0015175; GO:0015184; GO:0015297; GO:0015804; GO:0015811; GO:0016324; GO:0031526; GO:0042605; GO:0050900 0 0 0 PF13520; P86854 CHOYP_COL12.1.3 m.27221 sp PLCL_MYTGA 26.923 156 105 3 1 147 1 156 5.51E-17 76.3 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q06453 CHOYP_ARX.1.1 m.8413 sp AL_DROME 60.227 88 35 0 43 130 58 145 5.51E-28 113 AL_DROME reviewed Homeobox protein aristaless al CG3935 Drosophila melanogaster (Fruit fly) 408 "antennal morphogenesis [GO:0048800]; chaeta development [GO:0022416]; elongation of arista core [GO:0035015]; imaginal disc-derived leg morphogenesis [GO:0007480]; leg disc development [GO:0035218]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of Notch signaling pathway [GO:0045747]" GO:0005634; GO:0007480; GO:0022416; GO:0035015; GO:0035218; GO:0043234; GO:0043565; GO:0045747; GO:0045892; GO:0048800 0 0 0 PF00046;PF03826; Q4R4I6 CHOYP_LOC100710670.2.2 m.45011 sp CAP1_MACFA 51.793 251 95 3 2 252 250 474 5.51E-81 253 CAP1_MACFA reviewed Adenylyl cyclase-associated protein 1 (CAP 1) CAP1 QtrA-13003 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 475 actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902] GO:0000902; GO:0005886; GO:0030036 0 0 0 PF08603;PF01213; Q6AXZ2 CHOYP_BRAFLDRAFT_125776.1.2 m.36288 sp LRC46_RAT 50.98 153 72 3 47 198 19 169 5.51E-35 130 LRC46_RAT reviewed Leucine-rich repeat-containing protein 46 Lrrc46 Rattus norvegicus (Rat) 323 0 0 0 0 0 0 Q6NS45 CHOYP_BRAFLDRAFT_121183.7.8 m.55264 sp CCD66_MOUSE 39.098 133 81 0 744 876 438 570 5.51E-13 77.4 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q6PFY8 CHOYP_LOC100370588.19.19 m.65491 sp TRI45_MOUSE 29.187 209 116 7 48 238 127 321 5.51E-11 65.9 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6PGR9 CHOYP_LOC100930468.1.1 m.45238 sp TRI72_XENLA 34.375 96 46 3 41 136 12 90 5.51E-06 51.2 TRI72_XENLA reviewed Tripartite motif-containing protein 72 (Mitsugumin-53) (Mg53) trim72 mg53 Xenopus laevis (African clawed frog) 477 exocytosis [GO:0006887]; muscle organ development [GO:0007517]; muscle system process [GO:0003012]; plasma membrane repair [GO:0001778]; protein homooligomerization [GO:0051260] GO:0001778; GO:0001786; GO:0003012; GO:0006887; GO:0007517; GO:0008270; GO:0030659; GO:0042383; GO:0051260 0 0 0 PF13765;PF00622;PF00643; Q7TPV2 CHOYP_LOC100372567.3.5 m.36717 sp DZIP3_MOUSE 26.25 160 105 4 8 164 386 535 5.51E-08 58.2 DZIP3_MOUSE reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) 1204 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8N6F8 CHOYP_BRAFLDRAFT_126943.1.3 m.6839 sp WBS27_HUMAN 34.32 169 107 4 36 204 32 196 5.51E-24 99 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q93131 CHOYP_NEMVEDRAFT_V1G169611.1.1 m.25714 sp ACTC_BRAFL 66.667 222 51 4 1 220 119 319 5.51E-96 288 ACTC_BRAFL reviewed "Actin, cytoplasmic (BfCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma floridae (Florida lancelet) (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9ESN6 CHOYP_TRIM3.49.58 m.53282 sp TRIM2_MOUSE 28.23 209 126 6 76 273 536 731 5.51E-12 69.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9UK41 CHOYP_LOC101164168.1.1 m.24728 sp VPS28_HUMAN 68.468 222 64 3 1 218 1 220 5.51E-107 310 VPS28_HUMAN reviewed Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) VPS28 Homo sapiens (Human) 221 autophagy [GO:0006914]; endosomal transport [GO:0016197]; intracellular transport of virus [GO:0075733]; multivesicular body assembly [GO:0036258]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058] GO:0000813; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005886; GO:0006914; GO:0010008; GO:0016197; GO:0019058; GO:0031397; GO:0031902; GO:0032403; GO:0036258; GO:0039702; GO:0043130; GO:0043162; GO:0043328; GO:0045732; GO:0070062; GO:0075733; GO:2000397 0 0 0 PF03997; A9C3P0 CHOYP_LOC100740246.1.1 m.25108 sp MLEC_DANRE 51.613 279 118 6 20 283 9 285 5.52E-91 274 MLEC_DANRE reviewed Malectin mlec si:dkey-117k10.5 Danio rerio (Zebrafish) (Brachydanio rerio) 285 carbohydrate metabolic process [GO:0005975] GO:0005783; GO:0005789; GO:0005975; GO:0016021; GO:0030246 0 0 0 PF11721; A9ULC7 CHOYP_LOC100888334.1.1 m.40374 sp OSTA_XENTR 25.081 307 223 5 29 332 17 319 5.52E-24 103 OSTA_XENTR reviewed Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha) slc51a osta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 339 bile acid and bile salt transport [GO:0015721]; transport [GO:0006810] GO:0005215; GO:0005789; GO:0005886; GO:0006810; GO:0015721; GO:0016021; GO:0042803; GO:0043234; GO:0046982 0 0 0 PF03619; B4NFJ7 CHOYP_ISCW_ISCW018501.1.2 m.21028 sp LST2_DROWI 46.429 56 29 1 82 136 913 968 5.52E-10 59.7 LST2_DROWI reviewed Lateral signaling target protein 2 homolog GK22512 Drosophila willistoni (Fruit fly) 993 0 GO:0046872 0 0 0 PF01363; E1BD59 CHOYP_BRAFLDRAFT_85511.17.23 m.55470 sp TRI56_BOVIN 27.143 280 187 7 207 470 13 291 5.52E-32 133 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; F1NPG5 CHOYP_LOC100891651.1.1 m.11904 sp CENPT_CHICK 29.433 282 156 9 624 878 372 637 5.52E-24 111 CENPT_CHICK reviewed Centromere protein T (CENP-T) CENPT Gallus gallus (Chicken) 639 cell division [GO:0051301]; chromosome segregation [GO:0007059]; kinetochore assembly [GO:0051382]; mitotic nuclear division [GO:0007067] GO:0000777; GO:0003677; GO:0005634; GO:0007059; GO:0007067; GO:0051301; GO:0051382 0 0 0 PF16171; O14974 CHOYP_LOC100114433.1.4 m.363 sp MYPT1_HUMAN 60.49 286 113 0 12 297 2 287 5.52E-117 384 MYPT1_HUMAN reviewed Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) 1030 cellular response to drug [GO:0035690]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; negative regulation of catalytic activity [GO:0043086]; positive regulation of myosin-light-chain-phosphatase activity [GO:0035508]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of nucleocytoplasmic transport [GO:0046822] GO:0000086; GO:0000776; GO:0004721; GO:0004857; GO:0004871; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005925; GO:0006470; GO:0007067; GO:0015629; GO:0019208; GO:0019901; GO:0030018; GO:0030155; GO:0031672; GO:0035507; GO:0035508; GO:0035690; GO:0043086; GO:0043292; GO:0045944; GO:0046822; GO:0051297; GO:0071889; GO:0072357 0 0 0 PF12796;PF15898; O35474 CHOYP_NEMVEDRAFT_V1G207417.1.1 m.48558 sp EDIL3_MOUSE 28.571 196 128 5 179 362 121 316 5.52E-19 91.3 EDIL3_MOUSE reviewed EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) Edil3 Del1 Mus musculus (Mouse) 480 cell adhesion [GO:0007155]; multicellular organism development [GO:0007275]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0005509; GO:0007155; GO:0007275; GO:0010811; GO:0070062; GO:1903561 0 0 0 PF00008;PF00754;PF12661; O43854 CHOYP_MUC5A.2.2 m.48646 sp EDIL3_HUMAN 36.424 151 82 5 1486 1625 329 476 5.52E-18 92.8 EDIL3_HUMAN reviewed EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1) EDIL3 DEL1 Homo sapiens (Human) 480 cell adhesion [GO:0007155]; multicellular organism development [GO:0007275]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0005178; GO:0005509; GO:0007155; GO:0007275; GO:0010811; GO:0031012; GO:0070062; GO:1903561 0 0 0 PF00008;PF00754;PF12661; O50655 CHOYP_LOC100634784.1.1 m.10778 sp XERD_SELRU 24.161 298 193 10 15 298 32 310 5.52E-11 65.9 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; P07686 CHOYP_LOC100897999.1.1 m.2498 sp HEXB_HUMAN 46.589 513 250 10 39 538 50 551 5.52E-161 474 HEXB_HUMAN reviewed Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) 556 astrocyte cell migration [GO:0043615]; cellular calcium ion homeostasis [GO:0006874]; cellular protein metabolic process [GO:0044267]; chondroitin sulfate catabolic process [GO:0030207]; ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; hyaluronan catabolic process [GO:0030214]; keratan sulfate catabolic process [GO:0042340]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501] GO:0001501; GO:0001669; GO:0004563; GO:0006687; GO:0006689; GO:0006874; GO:0007040; GO:0007341; GO:0007605; GO:0007626; GO:0008049; GO:0008360; GO:0008375; GO:0008654; GO:0009313; GO:0016020; GO:0019915; GO:0030207; GO:0030214; GO:0042340; GO:0042552; GO:0042582; GO:0042803; GO:0043202; GO:0043615; GO:0044267; GO:0045944; GO:0046982; GO:0048477; GO:0050885; GO:0070062 0 0 0 PF00728;PF14845; P30974 CHOYP_NEMVEDRAFT_V1G240722.1.1 m.43918 sp TLR1_DROME 27.885 208 128 7 49 243 84 282 5.52E-10 65.1 TLR1_DROME reviewed Tachykinin-like peptides receptor 86C (NKD) TkR86C NKD Takr86C CG6515 Drosophila melanogaster (Fruit fly) 504 G-protein coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217] GO:0002121; GO:0004995; GO:0005887; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016021 0 0 0 PF00001; P32238 CHOYP_LOC100890822.2.2 m.23685 sp CCKAR_HUMAN 23.98 392 236 13 36 423 45 378 5.52E-12 70.9 CCKAR_HUMAN reviewed Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR CCKRA Homo sapiens (Human) 428 actin cytoskeleton reorganization [GO:0031532]; axonogenesis [GO:0007409]; cellular response to hormone stimulus [GO:0032870]; digestion [GO:0007586]; feeding behavior [GO:0007631]; forebrain development [GO:0030900]; gastric acid secretion [GO:0001696]; insulin secretion [GO:0030073]; neuron migration [GO:0001764]; organ regeneration [GO:0031100]; pancreas development [GO:0031016]; pancreatic juice secretion [GO:0030157]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of somatostatin secretion [GO:0090274]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of calcium ion transport [GO:0051924]; regulation of hormone secretion [GO:0046883]; regulation of potassium ion transport [GO:0043266]; response to glucocorticoid [GO:0051384]; response to heat [GO:0009408]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; response to radiation [GO:0009314]; response to starvation [GO:0042594]; temperature homeostasis [GO:0001659] GO:0001659; GO:0001696; GO:0001764; GO:0002023; GO:0004951; GO:0005764; GO:0005768; GO:0005783; GO:0005829; GO:0005886; GO:0005887; GO:0007200; GO:0007204; GO:0007409; GO:0007584; GO:0007586; GO:0007631; GO:0009314; GO:0009408; GO:0030073; GO:0030157; GO:0030900; GO:0031016; GO:0031100; GO:0031532; GO:0032496; GO:0032870; GO:0042594; GO:0043195; GO:0043266; GO:0046883; GO:0051384; GO:0051924; GO:0090274 0 0 0 PF00001;PF09193; P41595 CHOYP_HTR2B.1.1 m.121 sp 5HT2B_HUMAN 24.317 366 229 13 37 387 65 397 5.52E-11 67.4 5HT2B_HUMAN reviewed 5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B) HTR2B Homo sapiens (Human) 481 activation of phospholipase C activity [GO:0007202]; behavior [GO:0007610]; calcium-mediated signaling [GO:0019722]; cardiac muscle hypertrophy [GO:0003300]; cellular calcium ion homeostasis [GO:0006874]; cellular response to amine stimulus [GO:0071418]; cellular response to serotonin [GO:1904015]; cellular response to temperature stimulus [GO:0071502]; cGMP biosynthetic process [GO:0006182]; embryonic morphogenesis [GO:0048598]; ERK1 and ERK2 cascade [GO:0070371]; G-protein coupled receptor internalization [GO:0002031]; G-protein coupled receptor signaling pathway [GO:0007186]; heart morphogenesis [GO:0003007]; hepatic stellate cell activation [GO:0035733]; inositol phosphate metabolic process [GO:0043647]; intestine smooth muscle contraction [GO:0014827]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of cell death [GO:0060548]; neural crest cell differentiation [GO:0014033]; neural crest cell migration [GO:0001755]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphorylation [GO:0016310]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein kinase C signaling [GO:0070528]; regulation of behavior [GO:0050795]; release of sequestered calcium ion into cytosol [GO:0051209]; response to drug [GO:0042493]; serotonin receptor signaling pathway [GO:0007210]; vasoconstriction [GO:0042310] GO:0001755; GO:0001819; GO:0001938; GO:0001965; GO:0002031; GO:0003007; GO:0003300; GO:0004993; GO:0005096; GO:0005737; GO:0005886; GO:0005887; GO:0006182; GO:0006874; GO:0007186; GO:0007202; GO:0007205; GO:0007210; GO:0007610; GO:0008144; GO:0008284; GO:0010507; GO:0010513; GO:0014033; GO:0014065; GO:0014827; GO:0016310; GO:0019722; GO:0030054; GO:0030425; GO:0035733; GO:0042310; GO:0042493; GO:0043025; GO:0043066; GO:0043123; GO:0043406; GO:0043647; GO:0045202; GO:0048598; GO:0050715; GO:0050795; GO:0051000; GO:0051209; GO:0051378; GO:0051781; GO:0060548; GO:0070371; GO:0070374; GO:0070528; GO:0071418; GO:0071502; GO:1904015 0 0 0 PF00001; P51942 CHOYP_BRAFLDRAFT_117282.6.6 m.53715 sp MATN1_MOUSE 26.984 252 155 7 112 358 229 456 5.52E-15 84.7 MATN1_MOUSE reviewed Cartilage matrix protein (Matrilin-1) Matn1 Cmp Crtm Mus musculus (Mouse) 500 chondrocyte differentiation [GO:0002062]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; regulation of bone mineralization [GO:0030500] GO:0002062; GO:0003429; GO:0005201; GO:0005509; GO:0005578; GO:0030500 0 0 0 PF10393;PF00092; P62914 CHOYP_RL11.5.7 m.30542 sp RL11_RAT 85.526 152 22 0 12 163 7 158 5.52E-94 273 RL11_RAT reviewed 60S ribosomal protein L11 Rpl11 Rattus norvegicus (Rat) 178 negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; protein localization to nucleus [GO:0034504]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0019843; GO:0022625; GO:0022626; GO:0034504; GO:0042975; GO:0043433 0 0 0 PF00281;PF00673; Q27J81 CHOYP_INF2.4.5 m.37911 sp INF2_HUMAN 41.346 104 60 1 31 134 223 325 5.52E-12 67.8 INF2_HUMAN reviewed Inverted formin-2 (HBEBP2-binding protein C) INF2 C14orf151 C14orf173 Homo sapiens (Human) 1249 actin cytoskeleton organization [GO:0030036]; regulation of mitochondrial fission [GO:0090140] GO:0030036; GO:0048471; GO:0090140 0 0 0 PF06367;PF06371;PF02181;PF02205; Q4ZJM9 CHOYP_LOC100693208.7.8 m.52121 sp C1QL4_MOUSE 32.787 122 70 4 154 274 125 235 5.52E-08 55.8 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q54F46 CHOYP_LOC100637968.6.12 m.36686 sp WARA_DICDI 39.063 192 116 1 247 437 382 573 5.52E-30 127 WARA_DICDI reviewed Homeobox protein Wariai (Homeobox protein 1) (DdHbx-1) warA hbx1 wri DDB_G0291075 Dictyostelium discoideum (Slime mold) 803 "anatomical structure morphogenesis [GO:0009653]; multicellular organism development [GO:0007275]; protein targeting to plasma membrane [GO:0072661]; regulation of cell differentiation [GO:0045595]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007275; GO:0008093; GO:0009653; GO:0030507; GO:0043565; GO:0045595; GO:0072661 0 0 0 PF00023;PF12796;PF00046; Q54KD0 CHOYP_BRAFLDRAFT_122847.1.2 m.50414 sp Y7407_DICDI 29.73 111 76 2 15 124 959 1068 5.52E-10 60.1 Y7407_DICDI reviewed TPR repeat-containing protein DDB_G0287407 DDB_G0287407 Dictyostelium discoideum (Slime mold) 1663 0 0 0 0 0 PF13271; Q6INI5 CHOYP_NOL11.1.1 m.6423 sp NOL11_XENLA 23.375 723 435 20 20 643 18 720 5.52E-43 168 NOL11_XENLA reviewed Nucleolar protein 11 nol11 Xenopus laevis (African clawed frog) 720 "maturation of SSU-rRNA [GO:0030490]; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901838]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006351; GO:0030490; GO:1901838 0 0 0 0 Q8C4Y3 CHOYP_NELFB.2.2 m.43719 sp NELFB_MOUSE 59.477 153 61 1 1 152 2 154 5.52E-59 195 NELFB_MOUSE reviewed Negative elongation factor B (NELF-B) (Cofactor of BRCA1) Nelfb Cobra1 MNCb-5210 Mus musculus (Mouse) 580 "negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; transcription, DNA-templated [GO:0006351]" GO:0005654; GO:0005737; GO:0006351; GO:0032021; GO:0034244 0 0 0 PF06209; Q8K3K9 CHOYP_LOC100484230.1.1 m.50381 sp GIMA4_RAT 35.484 217 136 2 43 259 30 242 5.52E-39 142 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8VE97 CHOYP_LOC100376908.1.4 m.112 sp SRSF4_MOUSE 42.553 94 50 1 22 115 4 93 5.52E-16 79.3 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q8VE97 CHOYP_SRSF4.4.6 m.28747 sp SRSF4_MOUSE 81.481 54 10 0 1 54 124 177 5.52E-26 105 SRSF4_MOUSE reviewed "Serine/arginine-rich splicing factor 4 (Splicing factor, arginine/serine-rich 4)" Srsf4 Sfrs4 MNCb-2616 Mus musculus (Mouse) 489 "hematopoietic progenitor cell differentiation [GO:0002244]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0002244; GO:0005654; GO:0006397; GO:0008380; GO:0016607; GO:0044822; GO:0048025 0 0 0 PF00076; Q922J3 CHOYP_YM92.1.1 m.49782 sp CLIP1_MOUSE 58.571 70 29 0 57 126 211 280 5.52E-23 105 CLIP1_MOUSE reviewed CAP-Gly domain-containing linker protein 1 (Restin) Clip1 Kiaa4046 Rsn Mus musculus (Mouse) 1391 microtubule bundle formation [GO:0001578]; positive regulation of microtubule polymerization [GO:0031116]; protein transport into plasma membrane raft [GO:0044861] GO:0001578; GO:0001726; GO:0005635; GO:0005737; GO:0005813; GO:0005874; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0030659; GO:0031116; GO:0035371; GO:0044354; GO:0044861; GO:0051010; GO:1990752 0 0 0 PF01302;PF16641; Q92542 CHOYP_BRAFLDRAFT_115392.1.1 m.57264 sp NICA_HUMAN 36.901 710 406 19 39 728 15 702 5.52E-155 469 NICA_HUMAN reviewed Nicastrin NCSTN KIAA0253 UNQ1874/PRO4317 Homo sapiens (Human) 709 amyloid precursor protein catabolic process [GO:0042987]; beta-amyloid metabolic process [GO:0050435]; ephrin receptor signaling pathway [GO:0048013]; epithelial cell proliferation [GO:0050673]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; myeloid cell homeostasis [GO:0002262]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; protein processing [GO:0016485]; proteolysis [GO:0006508]; T cell proliferation [GO:0042098] GO:0002262; GO:0004175; GO:0005765; GO:0005783; GO:0005794; GO:0005886; GO:0005887; GO:0005925; GO:0006508; GO:0006509; GO:0007219; GO:0007220; GO:0016020; GO:0016021; GO:0016485; GO:0031293; GO:0042098; GO:0042470; GO:0042987; GO:0043065; GO:0043085; GO:0048013; GO:0050435; GO:0050673; GO:0070062 0 0 0 PF05450; Q99M80 CHOYP_LOC100890753.2.3 m.53551 sp PTPRT_MOUSE 27.876 739 485 18 285 981 721 1453 5.52E-76 276 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9H2Y9 CHOYP_LOC661450.1.1 m.1742 sp SO5A1_HUMAN 46.296 108 55 1 1 105 677 784 5.52E-27 108 SO5A1_HUMAN reviewed Solute carrier organic anion transporter family member 5A1 (Organic anion transporter polypeptide-related protein 4) (OATP-RP4) (OATPRP4) (Solute carrier family 21 member 15) SLCO5A1 OATP5A1 SLC21A15 Homo sapiens (Human) 848 sodium-independent organic anion transport [GO:0043252] GO:0005887; GO:0015347; GO:0043252 0 0 cd06174; PF07648;PF03137; Q9JHX4 CHOYP_LOC100541666.1.1 m.60093 sp CASP8_RAT 28.37 497 277 16 1 474 41 481 5.52E-48 175 CASP8_RAT reviewed Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Rattus norvegicus (Rat) 482 activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage differentiation [GO:0045651]; protein heterooligomerization [GO:0051291]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to cold [GO:0009409]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; TRAIL-activated apoptotic signaling pathway [GO:0036462] GO:0004197; GO:0005123; GO:0005164; GO:0005654; GO:0005739; GO:0005815; GO:0005829; GO:0006508; GO:0006915; GO:0008625; GO:0009409; GO:0030225; GO:0031264; GO:0031265; GO:0032025; GO:0032355; GO:0032403; GO:0032496; GO:0034612; GO:0035877; GO:0036462; GO:0042981; GO:0043005; GO:0043123; GO:0043124; GO:0043234; GO:0044297; GO:0045121; GO:0045471; GO:0045651; GO:0046677; GO:0051291; GO:0051603; GO:0071260; GO:0071407; GO:0097153; GO:0097194; GO:0097199; GO:0097202; GO:0097342 0 0 0 PF01335; Q9V4M2 CHOYP_BRAFLDRAFT_87322.2.10 m.20499 sp WECH_DROME 33.333 87 53 2 175 258 540 624 5.52E-07 54.7 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; Q9VQ93 CHOYP_MCMBP.1.2 m.3995 sp GOLP3_DROME 79.916 239 48 0 6 244 44 282 5.52E-140 398 GOLP3_DROME reviewed Golgi phosphoprotein 3 homolog sauron (Protein rotini) sau GOLPH3 l(2)s5379 rti CG7085 Drosophila melanogaster (Fruit fly) 294 "actomyosin contractile ring assembly [GO:0000915]; cleavage furrow formation [GO:0036089]; Golgi organization [GO:0007030]; male meiosis cytokinesis [GO:0007112]; meiosis I cytokinesis [GO:0007110]; meiosis II cytokinesis [GO:0007111]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; smoothened signaling pathway [GO:0007224]; spindle assembly [GO:0051225]; spindle assembly involved in male meiosis [GO:0007053]" GO:0000139; GO:0000281; GO:0000301; GO:0000915; GO:0005794; GO:0007030; GO:0007053; GO:0007110; GO:0007111; GO:0007112; GO:0007224; GO:0010314; GO:0015031; GO:0016023; GO:0017137; GO:0031985; GO:0032154; GO:0032266; GO:0036089; GO:0051225; GO:0070273; GO:0070300; GO:0090307 0 0 0 PF05719; Q9Y5A7 CHOYP_BRAFLDRAFT_67011.1.1 m.9730 sp NUB1_HUMAN 42.342 111 58 2 2 106 495 605 5.52E-18 81.3 NUB1_HUMAN reviewed NEDD8 ultimate buster 1 (Negative regulator of ubiquitin-like proteins 1) (Renal carcinoma antigen NY-REN-18) NUB1 NYREN18 Homo sapiens (Human) 615 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein ubiquitination [GO:0016567]; response to interferon-gamma [GO:0034341]; response to tumor necrosis factor [GO:0034612]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005634; GO:0006511; GO:0016567; GO:0032436; GO:0034341; GO:0034612 0 0 0 PF00627; A4IF63 CHOYP_BRAFLDRAFT_85511.7.23 m.32534 sp TRIM2_BOVIN 24.215 223 137 7 342 548 488 694 5.53E-10 65.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_85706.3.5 m.39443 sp TRIM3_HUMAN 30.833 120 78 3 440 556 627 744 5.53E-10 65.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P50102 CHOYP_LOC100573970.1.1 m.30365 sp UBP8_YEAST 23.596 267 177 10 612 855 111 373 5.53E-08 60.1 UBP8_YEAST reviewed Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) UBP8 YMR223W YM9959.05 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 471 "histone deubiquitination [GO:0016578]; histone H3-K4 methylation [GO:0051568]; histone H3-K79 methylation [GO:0034729]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0000124; GO:0004843; GO:0006351; GO:0006355; GO:0006511; GO:0008270; GO:0008380; GO:0016578; GO:0032947; GO:0034729; GO:0046695; GO:0051568; GO:0071819 0 0 0 PF00443;PF02148; Q08EJ0 CHOYP_LOC100373752.4.4 m.46402 sp PL8L1_MOUSE 32.203 118 78 2 4 120 41 157 5.53E-11 60.5 PL8L1_MOUSE reviewed PLAC8-like protein 1 Plac8l1 Mus musculus (Mouse) 177 0 0 0 0 0 PF04749; Q2TBI2 CHOYP_LOC100634182.1.1 m.48374 sp THAP4_BOVIN 37.037 108 60 3 1 101 1 107 5.53E-12 66.2 THAP4_BOVIN reviewed THAP domain-containing protein 4 THAP4 Bos taurus (Bovine) 584 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q3SWZ4 CHOYP_LOC100082337.1.1 m.10235 sp EXOS9_BOVIN 59.544 351 139 1 1 351 1 348 5.53E-145 430 EXOS9_BOVIN reviewed Exosome complex component RRP45 (Exosome component 9) EXOSC9 Bos taurus (Bovine) 440 "exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; U1 snRNA 3'-end processing [GO:0034473]; U4 snRNA 3'-end processing [GO:0034475]; U5 snRNA 3'-end processing [GO:0034476]" GO:0000176; GO:0000177; GO:0000178; GO:0000228; GO:0000467; GO:0005654; GO:0005730; GO:0017091; GO:0034427; GO:0034473; GO:0034475; GO:0034476; GO:0043928; GO:0071028; GO:0071035; GO:0071038; GO:0071042 0 0 cd11368; PF01138;PF03725; Q54SW1 CHOYP_BRAFLDRAFT_120431.1.1 m.49038 sp Y2179_DICDI 27.049 122 83 2 91 210 20 137 5.53E-08 53.5 Y2179_DICDI reviewed Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282179 DDB_G0282179 Dictyostelium discoideum (Slime mold) 145 lipid transport [GO:0006869] GO:0006869 0 0 0 PF02221; Q58CZ9 CHOYP_BRAFLDRAFT_275580.1.2 m.19622 sp ATTY_BOVIN 54.955 111 48 1 4 114 28 136 5.53E-30 115 ATTY_BOVIN reviewed Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase) TAT Bos taurus (Bovine) 447 biosynthetic process [GO:0009058]; cellular amino acid metabolic process [GO:0006520]; glutamate metabolic process [GO:0006536]; L-phenylalanine catabolic process [GO:0006559]; tyrosine catabolic process [GO:0006572] GO:0004838; GO:0005739; GO:0006520; GO:0006536; GO:0006559; GO:0006572; GO:0009058; GO:0016597; GO:0030170; GO:0080130 PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6. 0 0 PF00155;PF07706; Q8IDX6 CHOYP_contig_056248 m.66816 sp RBP2A_PLAF7 30.088 113 71 2 150 254 2748 2860 5.53E-06 52.8 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q9FY42 CHOYP_PHUM_PHUM323880.2.4 m.43885 sp HBL_MAIZE 26.974 152 106 3 30 177 12 162 5.53E-13 66.6 HBL_MAIZE reviewed Non-symbiotic hemoglobin (Hbm) (ZEAma GLB1) HB GLB1 Zea mays (Maize) 165 0 GO:0019825; GO:0020037; GO:0046872 0 0 0 PF00042; Q9H0J4 CHOYP_LOC100378873.3.3 m.30410 sp QRIC2_HUMAN 36.387 393 181 9 330 657 1227 1615 5.53E-66 242 QRIC2_HUMAN reviewed Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 0 0 0 0 0 PF16043; A4IF63 CHOYP_BRAFLDRAFT_87334.3.4 m.39018 sp TRIM2_BOVIN 34.653 101 64 2 3 101 631 731 5.54E-11 61.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; C3YWU0 CHOYP_LOC592142.8.9 m.62269 sp FUCO_BRAFL 63.333 330 120 1 21 349 17 346 5.54E-161 461 FUCO_BRAFL reviewed Alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase) BRAFLDRAFT_56888 Branchiostoma floridae (Florida lancelet) (Amphioxus) 449 fucose metabolic process [GO:0006004] GO:0004560; GO:0005576; GO:0006004 0 0 0 PF01120;PF16757; O15943 CHOYP_CADN.3.3 m.27486 sp CADN_DROME 30.244 1187 697 42 283 1398 483 1609 5.54E-97 352 CADN_DROME reviewed Neural-cadherin (Cadherin-N) (dN-cadherin) CadN CG7100 Drosophila melanogaster (Fruit fly) 3097 axonal fasciculation [GO:0007413]; axon extension [GO:0048675]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of dendrite morphogenesis [GO:0050774]; ommatidial rotation [GO:0016318]; R7 cell development [GO:0045467]; R8 cell development [GO:0045463]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of dendrite morphogenesis [GO:0048814]; retinal ganglion cell axon guidance [GO:0031290]; sensory perception of pain [GO:0019233] GO:0004872; GO:0005509; GO:0005886; GO:0005887; GO:0005911; GO:0007156; GO:0007411; GO:0007412; GO:0007413; GO:0008013; GO:0016021; GO:0016318; GO:0016339; GO:0019233; GO:0030424; GO:0030425; GO:0031290; GO:0042803; GO:0044331; GO:0045296; GO:0045463; GO:0045467; GO:0048675; GO:0048814; GO:0048841; GO:0048846; GO:0050774; GO:0050839 0 0 0 PF00028;PF01049;PF00008;PF02210; P23142 CHOYP_LOC100634184.2.3 m.15892 sp FBLN1_HUMAN 41.489 94 50 4 4 96 397 486 5.54E-12 63.5 FBLN1_HUMAN reviewed Fibulin-1 (FIBL-1) FBLN1 PP213 Homo sapiens (Human) 703 "blood coagulation, fibrin clot formation [GO:0072378]; embryo implantation [GO:0007566]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of transformation of host cell by virus [GO:1904188]; negative regulation of transforming growth factor-beta secretion [GO:2001202]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; viral process [GO:0016032]" GO:0001933; GO:0001968; GO:0005178; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0005604; GO:0005615; GO:0007162; GO:0007566; GO:0008022; GO:0010628; GO:0016032; GO:0016504; GO:0030198; GO:0032403; GO:0042802; GO:0048146; GO:0070051; GO:0070062; GO:0070373; GO:0071953; GO:0072378; GO:1900025; GO:1904188; GO:1904237; GO:2000146; GO:2000647; GO:2001202 0 0 0 PF12662;PF07645; Q27350 CHOYP_SIX1.1.2 m.49270 sp SO_DROME 34.706 170 102 4 55 219 135 300 5.54E-24 105 SO_DROME reviewed Protein sine oculis so CG11121 Drosophila melanogaster (Fruit fly) 416 Bolwig's organ morphogenesis [GO:0001746]; circadian rhythm [GO:0007623]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; entrainment of circadian clock [GO:0009649]; eye-antennal disc morphogenesis [GO:0007455]; glial cell migration [GO:0008347]; optic lobe placode formation [GO:0001744]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; ring gland development [GO:0035271]; spermatogenesis [GO:0007283] GO:0001744; GO:0001745; GO:0001746; GO:0003700; GO:0003705; GO:0005634; GO:0007283; GO:0007455; GO:0007623; GO:0008134; GO:0008347; GO:0009649; GO:0035271; GO:0043565; GO:0045944; GO:0048749 0 0 0 PF00046;PF16878; Q5F478 CHOYP_LOC583072.22.25 m.57128 sp ANR44_CHICK 23.724 784 477 18 895 1646 11 705 5.54E-39 162 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q60992 CHOYP_NEMVEDRAFT_V1G238125.1.1 m.44416 sp VAV2_MOUSE 39.286 84 40 2 230 313 663 735 5.54E-07 55.1 VAV2_MOUSE reviewed Guanine nucleotide exchange factor VAV2 (VAV-2) Vav2 Mus musculus (Mouse) 868 angiogenesis [GO:0001525]; cell migration [GO:0016477]; cell projection assembly [GO:0030031]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of blood coagulation [GO:0030193]; regulation of cell size [GO:0008361]; regulation of gene expression [GO:0010468]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264] GO:0001525; GO:0005085; GO:0005089; GO:0005154; GO:0005737; GO:0005829; GO:0005886; GO:0007264; GO:0008361; GO:0010468; GO:0016477; GO:0030031; GO:0030032; GO:0030168; GO:0030193; GO:0035023; GO:0043087; GO:0043552; GO:0046872 0 0 0 PF00130;PF11971;PF00169;PF00621;PF00017;PF07653; Q68CR1 CHOYP_BRAFLDRAFT_130493.1.1 m.34400 sp SE1L3_HUMAN 31.516 1009 636 19 75 1054 93 1075 5.54E-169 530 SE1L3_HUMAN reviewed Protein sel-1 homolog 3 (Suppressor of lin-12-like protein 3) (Sel-1L3) SEL1L3 KIAA0746 Homo sapiens (Human) 1132 0 GO:0005634; GO:0005654; GO:0016021 0 0 0 PF08238; Q6DFC2 CHOYP_LOC100376772.1.1 m.10397 sp CCD77_XENLA 56.442 489 179 7 21 488 19 494 5.54E-177 509 CCD77_XENLA reviewed Coiled-coil domain-containing protein 77 ccdc77 Xenopus laevis (African clawed frog) 496 0 0 0 0 0 0 Q6P7B7 CHOYP_ZFY27.1.1 m.31417 sp ZFY27_RAT 25.594 379 241 9 32 375 30 402 5.54E-25 108 ZFY27_RAT reviewed Protrudin (Zinc finger FYVE domain-containing protein 27) Zfyve27 Rattus norvegicus (Rat) 404 neuron projection development [GO:0031175]; neurotrophin TRK receptor signaling pathway [GO:0048011]; protein localization to plasma membrane [GO:0072659] GO:0005783; GO:0005789; GO:0016021; GO:0030424; GO:0030425; GO:0031175; GO:0032584; GO:0046872; GO:0048011; GO:0055038; GO:0072659 0 0 0 PF01363; Q7TQG1 CHOYP_LOC100889787.1.1 m.56671 sp PKHA6_MOUSE 47.17 106 50 4 480 581 54 157 5.54E-19 95.9 PKHA6_MOUSE reviewed Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) Plekha6 Pepp3 Mus musculus (Mouse) 1173 0 0 0 0 0 PF00169; Q8BU85 CHOYP_MSRB3.4.4 m.43455 sp MSRB3_MOUSE 55.414 157 68 2 15 170 71 226 5.54E-60 189 MSRB3_MOUSE reviewed "Methionine-R-sulfoxide reductase B3, mitochondrial (MsrB3) (EC 1.8.4.-)" Msrb3 Mus musculus (Mouse) 253 protein repair [GO:0030091]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005783; GO:0006979; GO:0008270; GO:0030091; GO:0033743 0 0 0 PF01641; Q8C854 CHOYP_MYEF2.1.1 m.18999 sp MYEF2_MOUSE 39.852 542 260 18 70 589 92 589 5.54E-85 279 MYEF2_MOUSE reviewed Myelin expression factor 2 (MEF-2) (MyEF-2) Myef2 Kiaa1341 Mef2 Mus musculus (Mouse) 591 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0000978; GO:0001078; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0044822 0 0 0 PF00076; Q8N2E2 CHOYP_LOC591161.2.2 m.47557 sp VWDE_HUMAN 41.143 175 100 3 67 239 1412 1585 5.54E-31 124 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8R3C6 CHOYP_RBM19.2.2 m.38975 sp RBM19_MOUSE 47.024 168 74 2 19 186 1 153 5.54E-40 149 RBM19_MOUSE reviewed Probable RNA-binding protein 19 (RNA-binding motif protein 19) Rbm19 Mus musculus (Mouse) 952 multicellular organism development [GO:0007275]; positive regulation of embryonic development [GO:0040019] GO:0000166; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0007275; GO:0016020; GO:0040019; GO:0044822 0 0 0 PF00076; Q8TDX9 CHOYP_LOC100375380.3.4 m.52454 sp PK1L1_HUMAN 25.283 2033 1224 59 1 1927 823 2666 5.54E-148 520 PK1L1_HUMAN reviewed Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1) PKD1L1 UNQ5785/PRO19563 Homo sapiens (Human) 2849 detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986]; single organismal cell-cell adhesion [GO:0016337] GO:0003127; GO:0005262; GO:0005929; GO:0016020; GO:0016337; GO:0031513; GO:0034704; GO:0050982; GO:0060170; GO:0070986 0 0 0 PF00801;PF08016;PF01477;PF02010; Q9D172 CHOYP_ES1.1.1 m.66406 sp ES1_MOUSE 59.533 257 95 4 4 255 11 263 5.54E-104 305 ES1_MOUSE reviewed "ES1 protein homolog, mitochondrial" D10Jhu81e Mus musculus (Mouse) 266 0 GO:0005739 0 0 0 0 Q9HC24 CHOYP_LFG4.1.1 m.57226 sp LFG4_HUMAN 43.103 116 66 0 10 125 15 130 5.54E-18 82.8 LFG4_HUMAN reviewed Protein lifeguard 4 (Golgi anti-apoptotic protein) (Protein S1R) (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) TMBIM4 GAAP LFG4 CGI-119 Homo sapiens (Human) 238 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; regulation of calcium-mediated signaling [GO:0050848] GO:0000139; GO:0005795; GO:0006915; GO:0016021; GO:0043066; GO:0050848 0 0 0 0 Q9ULB1 CHOYP_LOC100856796.1.3 m.4825 sp NRX1A_HUMAN 43.262 282 151 5 31 309 1019 1294 5.54E-68 234 NRX1A_HUMAN reviewed Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 KIAA0578 Homo sapiens (Human) 1477 "adult behavior [GO:0030534]; axon guidance [GO:0007411]; chemical synaptic transmission [GO:0007268]; gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; learning [GO:0007612]; neuroligin clustering involved in postsynaptic membrane assembly [GO:0097118]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; neurotransmitter secretion [GO:0007269]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synapse maturation [GO:0090129]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; prepulse inhibition [GO:0060134]; regulation of grooming behavior [GO:2000821]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; vocalization behavior [GO:0071625]; vocal learning [GO:0042297]" GO:0004872; GO:0005246; GO:0005509; GO:0005783; GO:0005886; GO:0005887; GO:0007158; GO:0007268; GO:0007269; GO:0007411; GO:0007416; GO:0007612; GO:0009986; GO:0030054; GO:0030534; GO:0031965; GO:0031982; GO:0033130; GO:0035176; GO:0042297; GO:0042734; GO:0043025; GO:0043234; GO:0050839; GO:0050885; GO:0051965; GO:0051968; GO:0060134; GO:0061178; GO:0071625; GO:0090129; GO:0097104; GO:0097109; GO:0097116; GO:0097118; GO:0097119; GO:2000463; GO:2000821 0 0 0 PF00008;PF02210;PF01034; O43257 CHOYP_LOC100649205.1.1 m.39938 sp ZNHI1_HUMAN 56.688 157 63 2 1 156 2 154 5.55E-51 162 ZNHI1_HUMAN reviewed Zinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein 1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet) ZNHIT1 CGBP1 ZNFN4A1 Homo sapiens (Human) 154 histone exchange [GO:0043486]; regulation of histone deacetylation [GO:0031063] GO:0000812; GO:0005634; GO:0031063; GO:0031491; GO:0042826; GO:0043486; GO:0046872 0 0 0 PF04438; O60462 CHOYP_NRP2.2.8 m.3907 sp NRP2_HUMAN 29.114 237 139 11 50 273 45 265 5.55E-18 88.2 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; O60673 CHOYP_REV3L.1.1 m.353 sp DPOLZ_HUMAN 38.947 570 272 16 1 534 1 530 5.55E-93 343 DPOLZ_HUMAN reviewed DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) REV3L POLZ REV3 Homo sapiens (Human) 3130 DNA-dependent DNA replication [GO:0006261]; error-prone translesion synthesis [GO:0042276] GO:0000166; GO:0003677; GO:0003887; GO:0005634; GO:0005654; GO:0005730; GO:0006261; GO:0008408; GO:0016035; GO:0042276; GO:0046872; GO:0051539 0 0 0 PF00136;PF03104;PF15735;PF14260; O75179 CHOYP_LOC753709.12.44 m.23557 sp ANR17_HUMAN 41.497 147 80 4 2 144 545 689 5.55E-21 91.7 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P02707 CHOYP_LOC100893009.1.1 m.10022 sp LECH_CHICK 31.667 120 75 4 376 494 93 206 5.55E-10 62.4 LECH_CHICK reviewed Hepatic lectin 0 Gallus gallus (Chicken) 207 endocytosis [GO:0006897] GO:0006897; GO:0016021; GO:0030246 0 0 0 PF00059; P22300 CHOYP_BRAFLDRAFT_64442.1.2 m.34815 sp GBRG2_BOVIN 24.453 274 180 8 23 276 79 345 5.55E-08 58.2 GBRG2_BOVIN reviewed Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) GABRG2 Bos taurus (Bovine) 475 cellular response to histamine [GO:0071420]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214] GO:0004890; GO:0005230; GO:0005254; GO:0005887; GO:0007214; GO:0030054; GO:0034707; GO:0045211; GO:0071420; GO:1902476; GO:1902711 0 0 0 PF02931;PF02932; P30985 CHOYP_HTF4.3.5 m.49739 sp HTF4_CHICK 43.381 491 197 23 262 697 168 632 5.55E-74 257 HTF4_CHICK reviewed Transcription factor 12 (TCF-12) (Class A helix-loop-helix transcription factor GE1) (E-box-binding protein) (Transcription factor HTF-4) (Fragment) TCF12 CTF4 Gallus gallus (Chicken) 657 "positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0042803; GO:0043425; GO:0045666; GO:0045944; GO:0046982; GO:0070888 0 0 0 PF00010; Q05A80 CHOYP_LOC100698649.3.8 m.28875 sp CAPR2_MOUSE 27.731 119 85 1 118 235 891 1009 5.55E-07 53.5 CAPR2_MOUSE reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) 1031 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q0E908 CHOYP_BRAFLDRAFT_92367.2.4 m.29877 sp HIL_DROME 26.966 267 188 4 62 322 511 776 5.55E-19 96.7 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q24799 CHOYP_LOC101173335.4.4 m.49816 sp MYPH_ECHGR 41.026 195 102 3 1 187 1 190 5.55E-40 137 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q24799 CHOYP_PHUM_PHUM002690.1.1 m.21364 sp MYPH_ECHGR 41.026 195 102 3 1 187 1 190 5.55E-40 137 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q25145 CHOYP_TPM2.8.8 m.50799 sp TPM_HALRU 73.391 233 62 0 10 242 28 260 5.55E-105 310 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q4U2R1 CHOYP_BRAFLDRAFT_120990.12.18 m.54924 sp HERC2_MOUSE 37.681 69 40 1 697 762 1865 1933 5.55E-06 54.3 HERC2_MOUSE reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) 4836 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005634; GO:0005737; GO:0005743; GO:0005814; GO:0006281; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; Q575T0 CHOYP_XGB.1.1 m.10099 sp CYGB1_ORYLA 30.556 144 94 3 29 167 24 166 5.55E-14 69.3 CYGB1_ORYLA reviewed Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 177 0 GO:0005344; GO:0005506; GO:0005737; GO:0019825; GO:0020037 0 0 0 PF00042; Q5ND28 CHOYP_LOC100182840.2.4 m.33829 sp SREC_MOUSE 38.168 131 76 4 194 322 215 342 5.55E-17 87 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RJ80 CHOYP_contig_043337 m.50067 sp CAPR2_DANRE 30.435 138 86 5 29 158 776 911 5.55E-08 54.3 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5UR67 CHOYP_LOC100638431.5.10 m.50252 sp RIBX_MIMIV 46.4 125 67 0 114 238 42 166 5.55E-27 105 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5ZIJ9 CHOYP_MIB.1.3 m.2822 sp MIB2_CHICK 32.338 770 474 11 6 736 12 773 5.55E-123 400 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q69Z28 CHOYP_ADAMTS18.1.2 m.4932 sp ATS16_MOUSE 29.885 348 189 15 216 553 290 592 5.55E-24 113 ATS16_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Adamts16 Kiaa2029 Mus musculus (Mouse) 1222 branching involved in ureteric bud morphogenesis [GO:0001658]; regulation of cilium assembly [GO:1902017]; regulation of systemic arterial blood pressure [GO:0003073] GO:0001658; GO:0003073; GO:0004222; GO:0005578; GO:0008270; GO:1902017 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q6NTZ6 CHOYP_FUT10.1.1 m.34218 sp FUT10_XENLA 43.478 414 212 8 89 497 72 468 5.55E-106 327 FUT10_XENLA reviewed "Alpha-(1,3)-fucosyltransferase 10 (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)" fut10 Xenopus laevis (African clawed frog) 469 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0032580; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q868Z9 CHOYP_DSEC_GM16292.1.1 m.12184 sp PPN_DROME 33.968 683 302 17 285 847 1490 2143 5.55E-99 358 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q8BZ20 CHOYP_LOC100665832.1.1 m.2957 sp PAR12_MOUSE 46.809 141 70 3 12 148 560 699 5.55E-34 134 PAR12_MOUSE reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) 711 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q8T674 CHOYP_AAEL_AAEL005244.1.1 m.10334 sp ABCGK_DICDI 33.604 369 232 4 1 367 361 718 5.55E-63 217 ABCGK_DICDI reviewed ABC transporter G family member 20 (ABC transporter ABCG.20) abcG20 DDB_G0267430 Dictyostelium discoideum (Slime mold) 730 transport [GO:0006810] GO:0005524; GO:0006810; GO:0042626; GO:0043190 0 0 0 PF00005; Q8UVC3 CHOYP_LOC660067.1.1 m.20127 sp INVS_CHICK 55.147 136 61 0 1 136 502 637 5.55E-44 159 INVS_CHICK reviewed Inversin INVS Gallus gallus (Chicken) 1106 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005737; GO:0005856; GO:0007275; GO:0016055 0 0 0 PF12796;PF00612; Q99LE6 CHOYP_ABCF2.2.2 m.44972 sp ABCF2_MOUSE 49.55 111 51 3 9 116 20 128 5.55E-22 93.2 ABCF2_MOUSE reviewed ATP-binding cassette sub-family F member 2 Abcf2 Mus musculus (Mouse) 628 0 GO:0005524; GO:0005739; GO:0016020; GO:0016887 0 0 0 PF00005;PF12848; O73791 CHOYP_CRE_01394.1.2 m.34798 sp TIE2_DANRE 31.818 88 56 2 16 101 246 331 5.56E-09 58.9 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; P0AGE8 CHOYP_LOC100370698.1.1 m.22760 sp CHRR_SHIFL 28.571 140 90 3 16 151 55 188 5.56E-06 47.4 CHRR_SHIFL reviewed Chromate reductase (CHRR) (EC 1.6.5.2) (NAD(P)H dehydrogenase (quinone)) chrR yieF SF3747 S4025 Shigella flexneri 188 0 GO:0003955 0 0 0 PF03358; P11233 CHOYP_RALA.3.4 m.25344 sp RALA_HUMAN 86.957 161 21 0 1 161 19 179 5.56E-100 290 RALA_HUMAN reviewed Ras-related protein Ral-A RALA RAL Homo sapiens (Human) 206 actin cytoskeleton reorganization [GO:0031532]; chemotaxis [GO:0006935]; cytokinesis [GO:0000910]; exocytosis [GO:0006887]; membrane organization [GO:0061024]; membrane raft localization [GO:0051665]; neural tube closure [GO:0001843]; positive regulation of filopodium assembly [GO:0051491]; Ras protein signal transduction [GO:0007265]; regulation of exocytosis [GO:0017157]; signal transduction [GO:0007165]; viral process [GO:0016032] GO:0000910; GO:0001843; GO:0003924; GO:0005525; GO:0005886; GO:0005925; GO:0006887; GO:0006935; GO:0007165; GO:0007265; GO:0009986; GO:0016032; GO:0017022; GO:0017157; GO:0019003; GO:0030496; GO:0030659; GO:0031532; GO:0031625; GO:0031755; GO:0032154; GO:0043209; GO:0051117; GO:0051491; GO:0051665; GO:0061024; GO:0070062 0 0 0 PF00071; P42325 CHOYP_NCAH.4.5 m.52379 sp NCAH_DROME 60.428 187 74 0 24 210 1 187 5.56E-83 247 NCAH_DROME reviewed Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) 190 0 GO:0005509 0 0 0 PF00036;PF13499; Q14690 CHOYP_RRP5.1.1 m.7375 sp RRP5_HUMAN 31.961 1142 656 29 36 1109 5 1093 5.56E-138 474 RRP5_HUMAN reviewed Protein RRP5 homolog (NF-kappa-B-binding protein) (NFBP) (Programmed cell death protein 11) PDCD11 KIAA0185 Homo sapiens (Human) 1871 mRNA processing [GO:0006397]; rRNA processing [GO:0006364] GO:0003723; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006364; GO:0006397; GO:0008134; GO:0032040; GO:0044822 0 0 0 PF00575;PF05843; Q2VLG6 CHOYP_LOC762897.3.3 m.42225 sp C163A_CANLF 41.333 225 110 7 203 421 158 366 5.56E-37 147 C163A_CANLF reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis lupus familiaris (Dog) (Canis familiaris) 1133 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q3UIR3 CHOYP_LOC100634077.1.1 m.20770 sp DTX3L_MOUSE 37.5 208 92 9 641 838 568 747 5.56E-27 121 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q3USW5 CHOYP_FXRD2.1.1 m.48848 sp FXRD2_MOUSE 45.926 270 142 3 1 267 311 579 5.56E-77 249 FXRD2_MOUSE reviewed FAD-dependent oxidoreductase domain-containing protein 2 Foxred2 D15Bwg0759e Mus musculus (Mouse) 665 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; oxidation-reduction process [GO:0055114] GO:0001948; GO:0004497; GO:0005788; GO:0030433; GO:0050660; GO:0055114 0 0 0 0 Q5UQ22 CHOYP_MG305.1.1 m.16768 sp YL207_MIMIV 22.65 234 163 6 57 278 71 298 5.56E-07 54.7 YL207_MIMIV reviewed Putative helicase L207/L206 (EC 3.6.4.-) MIMI_L206 MIMI_L207 Acanthamoeba polyphaga mimivirus (APMV) 960 0 GO:0004386; GO:0005524 0 0 0 PF08706;PF08707; Q8BXB6 CHOYP_SO2B1.1.1 m.2443 sp SO2B1_MOUSE 30.629 604 367 9 26 583 40 637 5.56E-82 276 SO2B1_MOUSE reviewed Solute carrier organic anion transporter family member 2B1 (Solute carrier family 21 member 9) Slco2b1 Oatp2b1 Slc21a9 Mus musculus (Mouse) 683 bile acid and bile salt transport [GO:0015721]; organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252] GO:0005887; GO:0008514; GO:0009925; GO:0015125; GO:0015347; GO:0015711; GO:0015721; GO:0043252 0 0 cd06174; PF03137; Q8R3W5 CHOYP_LOC577213.1.1 m.30837 sp SEN15_MOUSE 32.075 106 69 1 4 106 60 165 5.56E-09 55.1 SEN15_MOUSE reviewed tRNA-splicing endonuclease subunit Sen15 (tRNA-intron endonuclease Sen15) Tsen15 Sen15 Mus musculus (Mouse) 168 "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000213; GO:0005730; GO:0006388; GO:0006397 0 0 0 PF09631; Q8W257 CHOYP_LOC100208937.4.4 m.44194 sp PFI_PTIFI 22.244 499 327 15 57 519 24 497 5.56E-16 84 PFI_PTIFI reviewed Polyenoic fatty acid isomerase (PFI) (EC 5.3.3.13) 0 Ptilota filicina (Red alga) 500 0 GO:0016491; GO:0034016 0 0 0 PF01593; Q92122 CHOYP_SMP_065610.2.1.1 m.14249 sp KPYM_XENLA 47.458 59 31 0 55 113 469 527 5.56E-14 70.5 KPYM_XENLA reviewed Pyruvate kinase PKM (EC 2.7.1.40) (Cytosolic thyroid hormone-binding protein) (CTHBP) pkm Xenopus laevis (African clawed frog) 527 0 GO:0000287; GO:0004743; GO:0005524; GO:0016301; GO:0030955 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5. 0 0 PF00224;PF02887; Q9ESN6 CHOYP_LOC100213744.8.19 m.37264 sp TRIM2_MOUSE 25.116 215 148 6 343 550 536 744 5.56E-09 62.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9J5A7 CHOYP_TVAG_291510.9.9 m.53036 sp V155_FOWPN 27.059 255 138 10 1119 1361 217 435 5.56E-12 73.9 V155_FOWPN reviewed Putative ankyrin repeat protein FPV115 FPV115 Fowlpox virus (strain NVSL) (FPV) 542 0 0 0 0 0 PF00023;PF12796; Q9ULH0 CHOYP_NEMVEDRAFT_V1G244932.1.1 m.35179 sp KDIS_HUMAN 25.436 401 238 14 343 721 31 392 5.56E-14 80.1 KDIS_HUMAN reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) KIDINS220 ARMS KIAA1250 Homo sapiens (Human) 1771 activation of MAPKK activity [GO:0000186]; cellular response to nerve growth factor stimulus [GO:1990090]; dendrite morphogenesis [GO:0048813]; in utero embryonic development [GO:0001701]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976]; regulation of protein kinase activity [GO:0045859] GO:0000186; GO:0001701; GO:0005770; GO:0005829; GO:0010976; GO:0016020; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0043234; GO:0045859; GO:0048813; GO:1990090 0 0 0 PF12796;PF07693; Q9Y5N5 CHOYP_N6MT1.1.1 m.12960 sp HEMK2_HUMAN 53.052 213 97 2 25 237 5 214 5.56E-67 209 HEMK2_HUMAN reviewed HemK methyltransferase family member 2 (EC 2.1.1.-) (M.HsaHemK2P) (N(6)-adenine-specific DNA methyltransferase 1) N6AMT1 C21orf127 HEMK2 PRED28 Homo sapiens (Human) 214 methylation [GO:0032259]; positive regulation of cell growth [GO:0030307]; translational termination [GO:0006415] GO:0003676; GO:0005829; GO:0006415; GO:0008276; GO:0030307; GO:0032259; GO:0043234 0 0 0 PF05175; B8JMH0 CHOYP_BRAFLDRAFT_75724.1.1 m.13870 sp CAF17_DANRE 43.614 321 163 10 40 352 39 349 5.57E-79 249 CAF17_DANRE reviewed "Putative transferase CAF17 homolog, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog)" iba57 ch1073-162b20.1 Danio rerio (Zebrafish) (Brachydanio rerio) 354 heme biosynthetic process [GO:0006783]; iron-sulfur cluster assembly [GO:0016226] GO:0005759; GO:0006783; GO:0016226; GO:0016740 0 0 0 PF01571;PF08669; D2GXS7 CHOYP_LOC100370588.14.19 m.60864 sp TRIM2_AILME 23.779 307 199 12 287 572 429 721 5.57E-09 62.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43301 CHOYP_HSPA12A.4.27 m.20924 sp HS12A_HUMAN 29.571 629 378 14 9 583 56 673 5.57E-84 278 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P16157 CHOYP_AAEL_AAEL014742.2.8 m.21476 sp ANK1_HUMAN 33.987 459 273 2 3 431 32 490 5.57E-70 244 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20483 CHOYP_AGAP_AGAP003301.1.1 m.11962 sp MPIP_DROME 45.701 221 98 4 131 338 249 460 5.57E-60 204 MPIP_DROME reviewed M-phase inducer phosphatase (EC 3.1.3.48) (Cdc25-like protein) (Protein string) stg cdc25 CG1395 Drosophila melanogaster (Fruit fly) 479 "cell division [GO:0051301]; cell proliferation [GO:0008283]; centriole replication [GO:0007099]; G2/M transition of mitotic cell cycle [GO:0000086]; gastrulation [GO:0007369]; Golgi organization [GO:0007030]; histoblast morphogenesis [GO:0007488]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of cell size [GO:0045792]; negative regulation of mitotic cell cycle [GO:0045930]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of mitotic cell cycle, embryonic [GO:0045977]; protein dephosphorylation [GO:0006470]; regulation of cell diameter [GO:0060305]; regulation of mitotic cell cycle [GO:0007346]" GO:0000086; GO:0000278; GO:0004725; GO:0005634; GO:0005694; GO:0006470; GO:0007030; GO:0007067; GO:0007099; GO:0007346; GO:0007369; GO:0007422; GO:0007424; GO:0007488; GO:0007498; GO:0008138; GO:0008283; GO:0008284; GO:0045792; GO:0045930; GO:0045931; GO:0045977; GO:0046331; GO:0051301; GO:0060305 0 0 0 PF00581; P30937 CHOYP_PHUM_PHUM101310.1.1 m.44398 sp SSR4_RAT 44.407 295 152 5 41 333 36 320 5.57E-77 246 SSR4_RAT reviewed Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R) Sstr4 Rattus norvegicus (Rat) 384 "arachidonic acid metabolic process [GO:0019369]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; chemical synaptic transmission [GO:0007268]; forebrain development [GO:0030900]; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cAMP metabolic process [GO:0030815]; negative regulation of cell proliferation [GO:0008285]; positive regulation of MAPK cascade [GO:0043410]" GO:0004994; GO:0005737; GO:0005886; GO:0005887; GO:0007187; GO:0007268; GO:0008285; GO:0016477; GO:0019369; GO:0030815; GO:0030900; GO:0042923; GO:0043005; GO:0043410; GO:0071385 0 0 0 PF00001; Q13263 CHOYP_TBB.2.7 m.37920 sp TIF1B_HUMAN 28.431 102 62 2 11 101 153 254 5.57E-06 49.3 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q1L8J7 CHOYP_YAP.1.2 m.23386 sp YAP1_DANRE 38.544 467 190 18 10 414 11 442 5.57E-71 233 YAP1_DANRE reviewed Transcriptional coactivator YAP1 (Yes-associated protein 1) (zYAP) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) yap1 CH211-181P1.5-001 Danio rerio (Zebrafish) (Brachydanio rerio) 442 "dorsal/ventral axis specification [GO:0009950]; embryonic hemopoiesis [GO:0035162]; heart formation [GO:0060914]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0009950; GO:0010629; GO:0035162; GO:0043066; GO:0060914 0 0 0 PF00397; Q4QRH7 CHOYP_PEX16.1.1 m.51760 sp PEX16_DANRE 45.739 352 172 2 9 360 2 334 5.57E-98 296 PEX16_DANRE reviewed Peroxisomal membrane protein PEX16 (Peroxin-16) (Peroxisomal biogenesis factor 16) pex16 zgc:112248 Danio rerio (Zebrafish) (Brachydanio rerio) 335 peroxisome organization [GO:0007031] GO:0005778; GO:0007031; GO:0016021 0 0 0 PF08610; Q5BIM1 CHOYP_LIN41.2.3 m.35913 sp TRI45_BOVIN 25.07 359 221 11 19 338 29 378 5.57E-21 100 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5SWK7 CHOYP_RN145.1.1 m.40187 sp RN145_MOUSE 39.68 625 363 5 29 641 4 626 5.57E-156 467 RN145_MOUSE reviewed RING finger protein 145 Rnf145 Mus musculus (Mouse) 663 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0008270; GO:0016021; GO:0042787; GO:0043161; GO:0061630 0 0 0 PF13705;PF13639; Q63447 CHOYP_LOC100700643.1.1 m.7593 sp NPY4R_RAT 24.679 312 202 8 46 348 49 336 5.57E-12 69.7 NPY4R_RAT reviewed Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) Npy4r Ppyr1 Rattus norvegicus (Rat) 375 blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631] GO:0001601; GO:0001602; GO:0005887; GO:0007166; GO:0007631; GO:0008015; GO:0042277 0 0 0 PF00001; Q70PU1 CHOYP_LOC100379013.3.3 m.61813 sp PGSC2_DROSI 43.293 164 93 0 193 356 21 184 5.57E-47 160 PGSC2_DROSI reviewed Peptidoglycan-recognition protein SC2 (EC 3.5.1.28) PGRP-SC2 GD10595 Drosophila simulans (Fruit fly) 184 innate immune response [GO:0045087]; peptidoglycan catabolic process [GO:0009253] GO:0005576; GO:0008270; GO:0008745; GO:0009253; GO:0045087 0 0 cd06583; PF01510; Q9D1A2 CHOYP_LOC101066809.1.1 m.6848 sp CNDP2_MOUSE 70.279 323 95 1 2 324 139 460 5.57E-175 496 CNDP2_MOUSE reviewed Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) Cndp2 Cn2 Mus musculus (Mouse) 475 peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004180; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0008233; GO:0008270; GO:0016805; GO:0043171; GO:0070062; GO:0070573; GO:0102008 0 0 cd05676; PF07687;PF01546; Q9ESN6 CHOYP_BRAFLDRAFT_86890.2.4 m.23914 sp TRIM2_MOUSE 26.563 256 168 10 15 258 484 731 5.57E-14 75.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9R001 CHOYP_ATS4.1.1 m.21900 sp ATS5_MOUSE 31.855 248 133 10 3 233 393 621 5.57E-27 114 ATS5_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (ADMP-2) (Aggrecanase-2) (Implantin) Adamts5 Mus musculus (Mouse) 930 defense response to bacterium [GO:0042742] GO:0004222; GO:0005578; GO:0005615; GO:0008201; GO:0008237; GO:0008270; GO:0042742; GO:0050840 0 0 0 PF05986;PF01562;PF01421;PF00090; Q9U943 CHOYP_LOC100377089.1.2 m.5892 sp APLP_LOCMI 29.236 968 608 24 1 922 10 946 5.57E-106 386 APLP_LOCMI reviewed Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] 0 Locusta migratoria (Migratory locust) 3380 Wnt signaling pathway [GO:0016055] GO:0005319; GO:0005576; GO:0008289; GO:0016055 0 0 0 PF08742;PF06448;PF09172;PF01347;PF00094; Q9WU00 CHOYP_NEMVEDRAFT_V1G192750.1.1 m.51308 sp NRF1_MOUSE 35.514 107 59 4 13 109 173 279 5.57E-13 75.9 NRF1_MOUSE reviewed Nuclear respiratory factor 1 (NRF-1) (Alpha palindromic-binding protein) (Alpha-pal) Nrf1 Mus musculus (Mouse) 503 mitochondrion organization [GO:0007005]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001046; GO:0001077; GO:0003700; GO:0005634; GO:0005654; GO:0005667; GO:0007005; GO:0042803; GO:0045944; GO:0070062 0 0 0 PF10492;PF10491; E9QBI7 CHOYP_LOC594646.1.2 m.13864 sp OMA1_DANRE 32.584 267 155 4 24 277 59 313 5.58E-37 140 OMA1_DANRE reviewed "Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Overlapping with the m-AAA protease 1 homolog)" oma1 si:ch73-215a11.1 Danio rerio (Zebrafish) (Brachydanio rerio) 478 diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrial protein processing [GO:0034982]; negative regulation of mitochondrial fusion [GO:0010637]; response to stress [GO:0006950] GO:0002024; GO:0004222; GO:0005743; GO:0006006; GO:0006515; GO:0006629; GO:0006950; GO:0010637; GO:0016021; GO:0031966; GO:0034982; GO:0046872; GO:0097009 0 0 0 PF01435; O02833 CHOYP_LOC101067919.1.1 m.5278 sp ALS_PAPHA 22.65 234 153 4 32 238 41 273 5.58E-14 77.4 ALS_PAPHA reviewed Insulin-like growth factor-binding protein complex acid labile subunit (ALS) IGFALS ALS Papio hamadryas (Hamadryas baboon) 605 cell adhesion [GO:0007155] GO:0005615; GO:0007155 0 0 0 PF13855;PF01462; O60502 CHOYP_LOC100378403.1.1 m.26210 sp OGA_HUMAN 25.991 227 127 5 4 189 435 661 5.58E-17 82.4 OGA_HUMAN reviewed Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (EC 3.2.1.-) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT) MGEA5 HEXC KIAA0679 MEA5 Homo sapiens (Human) 916 glycoprotein catabolic process [GO:0006516]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517] GO:0004415; GO:0005634; GO:0005829; GO:0006044; GO:0006516; GO:0006517; GO:0016020; GO:0016231 0 0 0 PF07555; P34416 CHOYP_LASP1.2.2 m.40529 sp LASP1_CAEEL 66.667 141 45 1 1 139 1 141 5.58E-63 201 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P98203 CHOYP_PKP4.1.1 m.8551 sp ARVC_MOUSE 39.432 563 286 16 597 1136 343 873 5.58E-105 358 ARVC_MOUSE reviewed Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog Arvcf Mus musculus (Mouse) 962 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; multicellular organism development [GO:0007275]; single organismal cell-cell adhesion [GO:0016337] GO:0005634; GO:0005737; GO:0005886; GO:0007275; GO:0016337; GO:0016339 0 0 0 PF00514; Q11130 CHOYP_LOC100213495.1.2 m.24905 sp FUT7_HUMAN 29.818 275 168 9 24 289 46 304 5.58E-27 111 FUT7_HUMAN reviewed "Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase) (Selectin ligand synthase)" FUT7 Homo sapiens (Human) 342 "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; leukocyte migration involved in immune response [GO:0002522]; L-fucose catabolic process [GO:0042355]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]" GO:0000139; GO:0002361; GO:0002522; GO:0005794; GO:0006486; GO:0006487; GO:0008417; GO:0016020; GO:0016021; GO:0032580; GO:0042355; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q5M7F8 CHOYP_LOC100371099.1.1 m.20282 sp C070A_XENLA 54.545 121 55 0 1 121 23 143 5.58E-46 151 C070A_XENLA reviewed UPF0573 protein C2orf70 homolog A 0 Xenopus laevis (African clawed frog) 155 0 0 0 0 0 PF10629; Q6IQ97 CHOYP_OS03G0786500.1.1 m.18255 sp RBM41_DANRE 43.056 72 25 4 212 270 151 219 5.58E-06 51.2 RBM41_DANRE reviewed RNA-binding protein 4.1 (RNA-binding motif protein 4.1) rbm4.1 rbm4 Danio rerio (Zebrafish) (Brachydanio rerio) 419 0 GO:0000166; GO:0003723; GO:0005634; GO:0008270 0 0 0 PF00076;PF00098; Q6PDJ1 CHOYP_NEMVEDRAFT_V1G239644.4.4 m.53895 sp CAHD1_MOUSE 25.473 1056 679 41 26 1010 59 1077 5.58E-80 290 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q78P75 CHOYP_DYNLL2.2.2 m.37356 sp DYL2_RAT 96.629 89 3 0 57 145 1 89 5.58E-61 185 DYL2_RAT reviewed "Dynein light chain 2, cytoplasmic (Dynein light chain LC8-type 2)" Dynll2 Dlc2 Rattus norvegicus (Rat) 89 microtubule-based process [GO:0007017]; synaptic target recognition [GO:0008039]; transport [GO:0006810] GO:0003774; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0006810; GO:0007017; GO:0008039; GO:0008092; GO:0016020; GO:0016459; GO:0030286 0 0 0 PF01221; Q8IWZ3 CHOYP_LOC753709.35.44 m.59607 sp ANKH1_HUMAN 34.975 406 244 13 14 404 274 674 5.58E-45 170 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8K385 CHOYP_LOC100168620.2.4 m.18740 sp FRRS1_MOUSE 32.609 184 108 5 8 180 10 188 5.58E-20 93.2 FRRS1_MOUSE reviewed Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 Sdfr2 Sdr2 Mus musculus (Mouse) 592 0 GO:0000293; GO:0016021; GO:0046872 0 0 cd08544; PF03351;PF02014; Q96SN8 CHOYP_TVAG_268110.1.13 m.574 sp CK5P2_HUMAN 30.808 396 206 11 7 342 35 422 5.58E-29 131 CK5P2_HUMAN reviewed CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) CDK5RAP2 CEP215 KIAA1633 Homo sapiens (Human) 1893 "brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome organization [GO:0051297]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of neuron differentiation [GO:0045664]; regulation of spindle checkpoint [GO:0090231]" GO:0000086; GO:0000132; GO:0000226; GO:0000242; GO:0000922; GO:0001578; GO:0005516; GO:0005737; GO:0005794; GO:0005813; GO:0005829; GO:0005856; GO:0005874; GO:0007059; GO:0007099; GO:0007420; GO:0008017; GO:0015631; GO:0019901; GO:0022008; GO:0030054; GO:0031023; GO:0035371; GO:0044212; GO:0045664; GO:0045665; GO:0045893; GO:0046600; GO:0048471; GO:0051297; GO:0070062; GO:0090231; GO:0097431 0 0 0 PF07989; Q99NH0 CHOYP_LOC593853.2.4 m.37463 sp ANR17_MOUSE 35.458 251 151 8 1 243 368 615 5.58E-28 115 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9BXJ4 CHOYP_C1QT3.7.8 m.40185 sp C1QT3_HUMAN 31.818 154 92 6 32 177 92 240 5.58E-09 57 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9NRH2 CHOYP_LOC100742095.2.2 m.23738 sp SNRK_HUMAN 73.314 341 86 2 11 347 4 343 5.58E-177 535 SNRK_HUMAN reviewed SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase) SNRK KIAA0096 SNFRK Homo sapiens (Human) 765 intracellular signal transduction [GO:0035556]; myeloid cell differentiation [GO:0030099]; protein phosphorylation [GO:0006468] GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0030099; GO:0035556 0 0 0 PF00069; Q9UKW6 CHOYP_TAG-97.1.2 m.10435 sp ELF5_HUMAN 45.161 93 45 1 563 655 174 260 5.58E-19 90.9 ELF5_HUMAN reviewed ETS-related transcription factor Elf-5 (E74-like factor 5) (Epithelium-restricted ESE-1-related Ets factor) (Epithelium-specific Ets transcription factor 2) (ESE-2) ELF5 ESE2 Homo sapiens (Human) 265 cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; ectodermal cell fate commitment [GO:0001712]; mammary gland epithelial cell differentiation [GO:0060644]; negative regulation of cell differentiation [GO:0045596]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; somatic stem cell population maintenance [GO:0035019]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000977; GO:0000981; GO:0001228; GO:0001712; GO:0005634; GO:0005737; GO:0006357; GO:0006366; GO:0008283; GO:0030154; GO:0035019; GO:0045596; GO:0060644 0 0 0 PF00178;PF02198; A4IGP0 CHOYP_BRAFLDRAFT_113596.1.1 m.53557 sp HIKES_XENTR 56.345 197 83 3 1 195 1 196 5.59E-79 237 HIKES_XENTR reviewed Protein Hikeshi 0 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 197 cellular response to heat [GO:0034605]; protein import into nucleus [GO:0006606]; protein transport [GO:0015031] GO:0005622; GO:0005634; GO:0005829; GO:0006606; GO:0008565; GO:0015031; GO:0030544; GO:0034605 0 0 0 PF05603; A4IGP0 CHOYP_BRAFLDRAFT_206907.7.11 m.42201 sp HIKES_XENTR 56.345 197 83 3 1 195 1 196 5.59E-79 237 HIKES_XENTR reviewed Protein Hikeshi 0 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 197 cellular response to heat [GO:0034605]; protein import into nucleus [GO:0006606]; protein transport [GO:0015031] GO:0005622; GO:0005634; GO:0005829; GO:0006606; GO:0008565; GO:0015031; GO:0030544; GO:0034605 0 0 0 PF05603; D2GXS7 CHOYP_LOC100369333.25.32 m.53323 sp TRIM2_AILME 25.483 259 173 8 301 545 492 744 5.59E-12 72 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_67269.2.4 m.32395 sp TRIM3_HUMAN 26.316 209 127 9 261 457 536 729 5.59E-10 65.1 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_87327.8.13 m.41967 sp TRIM3_HUMAN 27.481 131 86 4 108 230 614 743 5.59E-08 57.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P12111 CHOYP_LOC100709262.2.2 m.61236 sp CO6A3_HUMAN 31.293 147 95 1 5 145 16 162 5.59E-16 78.2 CO6A3_HUMAN reviewed Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) 3177 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; muscle organ development [GO:0007517] GO:0004867; GO:0005576; GO:0005578; GO:0005589; GO:0005615; GO:0005788; GO:0007155; GO:0007517; GO:0030198; GO:0030574; GO:0031012; GO:0042383; GO:0070062; GO:1903561 0 0 0 PF01391;PF00014;PF00092; P31597 CHOYP_BRAFLDRAFT_67483.1.1 m.55097 sp EAA3_RABIT 50.775 516 214 9 18 530 12 490 5.59E-172 499 EAA3_RABIT reviewed Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1) SLC1A1 EAAC1 EAAT3 Oryctolagus cuniculus (Rabbit) 524 cysteine transport [GO:0042883]; D-aspartate import [GO:0070779]; L-glutamate transmembrane transport [GO:0089711] GO:0005313; GO:0005886; GO:0015293; GO:0016021; GO:0016324; GO:0033229; GO:0042883; GO:0070779; GO:0089711 0 0 0 PF00375; P49395 CHOYP_RS3A.11.15 m.43498 sp RS3A_APLCA 70.455 132 36 1 11 139 134 265 5.59E-62 194 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P56719 CHOYP_NMUR1.1.1 m.63505 sp OX2R_RAT 25.948 343 218 15 45 374 62 381 5.59E-20 94.7 OX2R_RAT reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) Hcrtr2 Rattus norvegicus (Rat) 460 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0004930; GO:0005887; GO:0007186; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P59111 CHOYP_KCNH8.1.2 m.9257 sp KCNH8_MOUSE 50.833 120 48 2 1 109 590 709 5.59E-29 121 KCNH8_MOUSE reviewed Potassium voltage-gated channel subfamily H member 8 (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (Voltage-gated potassium channel subunit Kv12.1) Kcnh8 Mus musculus (Mouse) 1102 regulation of membrane potential [GO:0042391] GO:0000155; GO:0005249; GO:0005622; GO:0005887; GO:0042391 0 0 0 PF00027;PF00520;PF13426; P86786 CHOYP_GIGA3.1.1 m.42774 sp GIGA3_CRAGI 99.512 205 1 0 359 563 1 205 5.59E-144 426 GIGA3_CRAGI reviewed Gigasin-3a (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 284 0 0 0 0 0 0 Q01241 CHOYP_BRAFLDRAFT_282105.2.2 m.59786 sp NF70_DORPE 50.575 87 41 1 27 113 52 136 5.59E-17 78.6 NF70_DORPE reviewed 70 kDa neurofilament protein (NF70) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 615 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q08AE8 CHOYP_SPIR1.1.1 m.55859 sp SPIR1_HUMAN 45.251 358 174 8 13 355 36 386 5.59E-83 291 SPIR1_HUMAN reviewed Protein spire homolog 1 (Spir-1) SPIRE1 KIAA1135 SPIR1 Homo sapiens (Human) 756 actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005856; GO:0005886; GO:0005938; GO:0015031; GO:0016192; GO:0030036; GO:0030659; GO:0036089; GO:0040038; GO:0045010; GO:0046907; GO:0048471; GO:0051295; GO:0070649 0 0 0 PF16474; Q5BKQ4 CHOYP_BRAFLDRAFT_225844.1.2 m.5122 sp LIPR1_MOUSE 41.573 356 190 7 10 349 2 355 5.59E-88 275 LIPR1_MOUSE reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) Pnliprp1 Mus musculus (Mouse) 473 lipid metabolic process [GO:0006629] GO:0004806; GO:0005509; GO:0005576; GO:0006629 0 0 0 PF00151;PF01477; Q5G271 CHOYP_NEMVEDRAFT_V1G141947.1.1 m.36594 sp NETR_PANTR 57 100 43 0 153 252 500 599 5.59E-31 124 NETR_PANTR reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Pan troglodytes (Chimpanzee) 875 exocytosis [GO:0006887]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006887; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195 0 0 cd00190; PF00051;PF00530;PF00089; Q5I0P2 CHOYP_GCSH.1.1 m.61889 sp GCSH_RAT 59.091 132 54 0 63 194 36 167 5.59E-50 162 GCSH_RAT reviewed "Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)" Gcsh Rattus norvegicus (Rat) 170 glycine decarboxylation via glycine cleavage system [GO:0019464] GO:0004047; GO:0005739; GO:0005960; GO:0019464; GO:0019899 0 0 cd06848; 0 Q6P073 CHOYP_UB2J2.1.2 m.3608 sp UB2J2_MOUSE 66.929 254 63 2 2 234 5 258 5.59E-121 347 UB2J2_MOUSE reviewed Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2) Ube2j2 Ncube2 Mus musculus (Mouse) 259 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein polyubiquitination [GO:0000209]; response to unfolded protein [GO:0006986] GO:0000151; GO:0000209; GO:0005524; GO:0005783; GO:0005789; GO:0006986; GO:0016021; GO:0030433; GO:0031625; GO:0061630; GO:0061631; GO:1903955 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q6P073 CHOYP_UB2J2.2.2 m.64184 sp UB2J2_MOUSE 66.929 254 63 2 2 234 5 258 5.59E-121 347 UB2J2_MOUSE reviewed Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2) Ube2j2 Ncube2 Mus musculus (Mouse) 259 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein polyubiquitination [GO:0000209]; response to unfolded protein [GO:0006986] GO:0000151; GO:0000209; GO:0005524; GO:0005783; GO:0005789; GO:0006986; GO:0016021; GO:0030433; GO:0031625; GO:0061630; GO:0061631; GO:1903955 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q7ZYF1 CHOYP_LOC100368102.1.1 m.27424 sp DJ27A_XENLA 38.095 168 99 2 31 193 17 184 5.59E-39 137 DJ27A_XENLA reviewed DnaJ homolog subfamily C member 27-A (Rab and DnaJ domain-containing protein 1) (Rab and DnaJ domain-containing protein A) dnajc27-a rbj-a rbj1 Xenopus laevis (African clawed frog) 273 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005634; GO:0007264 0 0 cd06257; PF00226;PF00071; Q8NBX0 CHOYP_SCPDL.1.1 m.55687 sp SCPDL_HUMAN 46.604 427 215 7 2 418 1 424 5.59E-129 381 SCPDL_HUMAN reviewed Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-) SCCPDH CGI-49 Homo sapiens (Human) 429 0 GO:0005634; GO:0005739; GO:0005811; GO:0016020; GO:0016491; GO:0030496 0 0 0 PF03435; Q8NDI1 CHOYP_EHBP1.2.2 m.60145 sp EHBP1_HUMAN 45.075 599 262 10 2 546 3 588 5.59E-152 488 EHBP1_HUMAN reviewed EH domain-binding protein 1 EHBP1 KIAA0903 NACSIN Homo sapiens (Human) 1231 0 GO:0005737; GO:0005886 0 0 0 PF00307;PF12130;PF10358; Q8TCE6 CHOYP_FAM45A.1.1 m.20926 sp FA45A_HUMAN 51.389 72 32 2 40 109 16 86 5.59E-15 72 FA45A_HUMAN reviewed Protein FAM45A FAM45A Homo sapiens (Human) 357 0 0 0 0 0 0 Q92847 CHOYP_LOC100377176.1.1 m.25526 sp GHSR_HUMAN 24.528 371 212 15 2 351 13 336 5.59E-13 72.8 GHSR_HUMAN reviewed Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) 366 actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin stimulus [GO:0032869]; decidualization [GO:0046697]; G-protein coupled receptor signaling pathway [GO:0007186]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 biosynthetic process [GO:0045409]; negative regulation of tumor necrosis factor biosynthetic process [GO:0042536]; positive regulation of appetite [GO:0032100]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; regulation of hindgut contraction [GO:0043134]; regulation of synapse assembly [GO:0051963]; response to food [GO:0032094]; response to hormone [GO:0009725] GO:0001616; GO:0004930; GO:0005886; GO:0007186; GO:0008154; GO:0008343; GO:0009725; GO:0009755; GO:0009986; GO:0016021; GO:0016520; GO:0017046; GO:0030252; GO:0032094; GO:0032100; GO:0032691; GO:0032869; GO:0040018; GO:0042536; GO:0043005; GO:0043134; GO:0043568; GO:0045121; GO:0045409; GO:0045923; GO:0046676; GO:0046697; GO:0050728; GO:0051963 0 0 0 PF00001; Q9ULJ7 CHOYP_AFUA_1G01020.11.50 m.21396 sp ANR50_HUMAN 35.337 549 350 1 2 545 527 1075 5.59E-88 300 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A9CJC9 CHOYP_LOC100486741.1.2 m.19339 sp PHRA_AGRFC 35.351 413 246 9 9 412 77 477 5.60E-67 226 PHRA_AGRFC reviewed Deoxyribodipyrimidine photo-lyase (EC 4.1.99.3) (Cyclobutane pyrimidine dimer photolyase) (CPD photolyase) (DNA photolyase PhrA) (Photoreactivating enzyme PhrA) phrA Atu1218 Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) 479 photoreactive repair [GO:0000719]; protein-chromophore linkage [GO:0018298] GO:0000719; GO:0003677; GO:0003904; GO:0018298; GO:0071949 0 0 0 PF00875;PF03441; D3ZAT9 CHOYP_FAXC.1.1 m.63178 sp FAXC_RAT 39.759 249 133 6 47 282 90 334 5.60E-51 176 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; P53476 CHOYP_A1.1.1 m.38445 sp ACT_TOXGO 39.844 128 61 6 13 140 10 121 5.60E-17 79.3 ACT_TOXGO reviewed Actin ACT1 Toxoplasma gondii 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P70193 CHOYP_CAOG_08239.1.3 m.40584 sp LRIG1_MOUSE 26.151 478 271 14 69 537 80 484 5.60E-20 100 LRIG1_MOUSE reviewed Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) Lrig1 Mus musculus (Mouse) 1091 innervation [GO:0060384]; otolith morphogenesis [GO:0032474]; sensory perception of sound [GO:0007605] GO:0007605; GO:0016021; GO:0032474; GO:0060384 0 0 0 PF07679;PF13855;PF01463;PF01462; Q18786 CHOYP_NEMVEDRAFT_V1G247177.1.1 m.63233 sp SMD2_CAEEL 81.579 114 21 0 6 119 5 118 5.60E-57 175 SMD2_CAEEL reviewed Probable small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) snr-4 C52E4.3 Caenorhabditis elegans 118 spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0005682; GO:0005685; GO:0005686; GO:0046540; GO:0071011; GO:0071013 0 0 0 PF01423; Q28199 CHOYP_LOC664019.1.1 m.28037 sp CD5R1_BOVIN 45.277 307 133 7 1 286 1 293 5.60E-83 254 CD5R1_BOVIN reviewed "Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)]" CDK5R1 CDK5R NCK5A Bos taurus (Bovine) 307 "axonal fasciculation [GO:0007413]; axon guidance [GO:0007411]; brain development [GO:0007420]; cerebellum development [GO:0021549]; embryo development [GO:0009790]; ephrin receptor signaling pathway [GO:0048013]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; layer formation in cerebral cortex [GO:0021819]; negative regulation of axon extension [GO:0030517]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of microtubule cytoskeleton organization [GO:0070507]; rhythmic process [GO:0048511]; serine phosphorylation of STAT3 protein [GO:0033136]; superior olivary nucleus maturation [GO:0021722]" GO:0001764; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007158; GO:0007213; GO:0007411; GO:0007413; GO:0007420; GO:0009790; GO:0014069; GO:0016020; GO:0016301; GO:0016533; GO:0016534; GO:0018107; GO:0021549; GO:0021722; GO:0021766; GO:0021819; GO:0030182; GO:0030424; GO:0030425; GO:0030426; GO:0030517; GO:0031175; GO:0031594; GO:0032956; GO:0033136; GO:0035235; GO:0043025; GO:0043197; GO:0043292; GO:0043525; GO:0043539; GO:0045296; GO:0045892; GO:0048013; GO:0048471; GO:0048511; GO:0061001; GO:0070507; GO:0071158; GO:0090314 0 0 0 PF03261; Q40642 CHOYP_CML11.1.2 m.11181 sp CML1_ORYSI 36.842 133 81 1 66 198 13 142 5.60E-20 91.7 CML1_ORYSI reviewed Calmodulin-like protein 1 (OsCaM61) CML1 OsI_004066 Oryza sativa subsp. indica (Rice) 187 0 GO:0005509; GO:0016020 0 0 0 PF13499; Q68EM7 CHOYP_RHG44.1.1 m.982 sp RHG17_HUMAN 50.331 453 216 5 7 454 1 449 5.60E-148 463 RHG17_HUMAN reviewed Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) ARHGAP17 RICH1 MSTP066 MSTP110 Homo sapiens (Human) 881 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0005886; GO:0005923; GO:0007165; GO:0051056 0 0 0 PF03114;PF00620; Q6PFY8 CHOYP_LOC100369333.14.32 m.32582 sp TRI45_MOUSE 31.373 204 120 6 5 196 127 322 5.60E-15 81.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7E1 CHOYP_OSHV1_GP060.1.1 m.28282 sp Y088_OSHVF 25.167 449 278 21 71 498 140 551 5.60E-11 69.3 Y088_OSHVF reviewed Putative transmembrane protein ORF88 ORF88 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 748 0 GO:0016021; GO:0033644 0 0 0 0 Q8NFD2 CHOYP_AASI_1435.22.35 m.54474 sp ANKK1_HUMAN 32.955 264 161 4 722 985 365 612 5.60E-27 121 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8WYN3 CHOYP_LOC101155731.1.1 m.53109 sp CSRN3_HUMAN 48.029 279 111 5 1 249 5 279 5.60E-70 239 CSRN3_HUMAN reviewed Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2) CSRNP3 FAM130A2 TAIP2 Homo sapiens (Human) 585 apoptotic process [GO:0006915]; negative regulation of phosphatase activity [GO:0010923]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001228; GO:0003700; GO:0005634; GO:0006915; GO:0010923; GO:0043065; GO:0043565; GO:0045944 0 0 0 PF16019; Q92673 CHOYP_LOC100368490.1.1 m.29618 sp SORL_HUMAN 50 76 37 1 29 103 1156 1231 5.60E-18 87.4 SORL_HUMAN reviewed Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) SORL1 C11orf32 Homo sapiens (Human) 2214 cholesterol metabolic process [GO:0008203]; lipid transport [GO:0006869]; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902960]; negative regulation of beta-amyloid formation [GO:1902430]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of neurofibrillary tangle assembly [GO:1902997]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein oligomerization [GO:0032460]; negative regulation of tau-protein kinase activity [GO:1902948]; positive regulation of choline O-acetyltransferase activity [GO:1902771]; positive regulation of early endosome to recycling endosome transport [GO:1902955]; positive regulation of endocytic recycling [GO:2001137]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to early endosome [GO:1902966]; post-Golgi vesicle-mediated transport [GO:0006892]; protein maturation [GO:0051604]; protein retention in Golgi apparatus [GO:0045053]; protein targeting [GO:0006605]; protein targeting to Golgi [GO:0000042]; protein targeting to lysosome [GO:0006622]; receptor-mediated endocytosis [GO:0006898]; regulation of smooth muscle cell migration [GO:0014910] GO:0000042; GO:0001540; GO:0004888; GO:0005615; GO:0005641; GO:0005768; GO:0005769; GO:0005783; GO:0005794; GO:0005802; GO:0005887; GO:0006605; GO:0006622; GO:0006869; GO:0006892; GO:0006898; GO:0008203; GO:0014910; GO:0016020; GO:0030169; GO:0030306; GO:0031985; GO:0032091; GO:0032460; GO:0034362; GO:0043407; GO:0045053; GO:0045732; GO:0050768; GO:0051604; GO:0055037; GO:0070062; GO:0070863; GO:1901215; GO:1902430; GO:1902771; GO:1902948; GO:1902953; GO:1902955; GO:1902960; GO:1902963; GO:1902966; GO:1902997; GO:2001137 0 0 0 PF00041;PF00057;PF00058;PF15902;PF15901; Q95JD5 CHOYP_LOC101169780.1.1 m.46531 sp ST1B1_CANLF 32 225 133 6 18 229 17 234 5.60E-25 103 ST1B1_CANLF reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (cSULT1B1) (EC 2.8.2.-) SULT1B1 ST1B2 Canis lupus familiaris (Dog) (Canis familiaris) 296 epithelial cell differentiation [GO:0030855]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005737; GO:0006805; GO:0008202; GO:0009812; GO:0030855; GO:0042403; GO:0051923 0 0 0 PF00685; Q98TR7 CHOYP_RS16.5.5 m.64462 sp RS16_HETFO 87.586 145 18 0 5 149 2 146 5.60E-90 261 RS16_HETFO reviewed 40S ribosomal protein S16 rps16 Heteropneustes fossilis (Stinging catfish) 146 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00380; Q9H8L6 CHOYP_CBLN13.6.9 m.46441 sp MMRN2_HUMAN 33.333 138 81 4 101 237 822 949 5.60E-12 68.2 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; A4IIL4 CHOYP_BRAFLDRAFT_115208.1.1 m.52467 sp BROX_XENTR 49.286 420 202 4 1 418 1 411 5.61E-143 416 BROX_XENTR reviewed BRO1 domain-containing protein BROX (BRO1 domain- and CAAX motif-containing protein) brox Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 411 0 GO:0016020 0 0 0 PF03097; A6QPC8 CHOYP_NSMCE4A.1.1 m.56171 sp EID3_BOVIN 29.204 226 144 3 28 240 49 271 5.61E-19 92.4 EID3_BOVIN reviewed EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) EID3 Bos taurus (Bovine) 379 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005737; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0030915 0 0 0 PF15412;PF08743; P08548 CHOYP_LOC100256388.1.1 m.55150 sp LIN1_NYCCO 29.697 330 221 6 1 323 562 887 5.61E-34 138 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; Q07969 CHOYP_LOC583590.1.1 m.49389 sp CD36_RAT 37.313 134 81 2 13 145 338 469 5.61E-25 102 CD36_RAT reviewed Platelet glycoprotein 4 (Adipocyte membrane protein) (Fatty acid translocase) (Fatty acid transport protein) (Glycoprotein IIIb) (GPIIIB) (PAS IV) (PAS-4) (Platelet glycoprotein IV) (GPIV) (CD antigen CD36) Cd36 Fat Rattus norvegicus (Rat) 472 amyloid fibril formation [GO:1990000]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; cell surface receptor signaling pathway [GO:0007166]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to insulin stimulus [GO:0032869]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cholesterol import [GO:0070508]; digestive tract development [GO:0048565]; eating behavior [GO:0042755]; fatty acid metabolic process [GO:0006631]; fatty acid oxidation [GO:0019395]; fatty acid transport [GO:0015908]; glucose homeostasis [GO:0042593]; immune response [GO:0006955]; interleukin-1 beta secretion [GO:0050702]; intestinal absorption [GO:0050892]; intestinal cholesterol absorption [GO:0030299]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; maternal placenta development [GO:0001893]; negative regulation of angiogenesis [GO:0016525]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of phagocytosis [GO:0050766]; positive regulation of triglyceride metabolic process [GO:0090208]; receptor internalization [GO:0031623]; regulation of energy homeostasis [GO:2000505]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to fatty acid [GO:0070542]; response to growth hormone [GO:0060416]; response to linoleic acid [GO:0070543]; response to lipid [GO:0033993]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; sensory perception of taste [GO:0050909]; triglyceride metabolic process [GO:0006641]; triglyceride transport [GO:0034197] GO:0001676; GO:0001893; GO:0003085; GO:0005622; GO:0005739; GO:0005783; GO:0005794; GO:0005886; GO:0005901; GO:0006631; GO:0006641; GO:0006955; GO:0007166; GO:0007204; GO:0007584; GO:0009612; GO:0009986; GO:0014823; GO:0015908; GO:0015909; GO:0016021; GO:0016324; GO:0016525; GO:0019395; GO:0030299; GO:0031526; GO:0031623; GO:0032355; GO:0032869; GO:0033993; GO:0034197; GO:0042383; GO:0042493; GO:0042593; GO:0042755; GO:0043231; GO:0043234; GO:0044539; GO:0045177; GO:0048565; GO:0050431; GO:0050702; GO:0050715; GO:0050766; GO:0050892; GO:0050909; GO:0060416; GO:0070053; GO:0070508; GO:0070538; GO:0070542; GO:0070543; GO:0071404; GO:0071726; GO:0090208; GO:0098742; GO:1900227; GO:1990000; GO:2000505 0 0 0 PF01130; Q86WV6 CHOYP_STING.2.3 m.53202 sp STING_HUMAN 34.27 178 107 6 516 685 154 329 5.61E-19 92.8 STING_HUMAN reviewed Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173) TMEM173 ERIS MITA STING Homo sapiens (Human) 379 "activation of innate immune response [GO:0002218]; apoptotic process [GO:0006915]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to organic cyclic compound [GO:0071407]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of protein binding [GO:0032092]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of type I interferon production [GO:0032479]" GO:0002218; GO:0002230; GO:0005741; GO:0005777; GO:0005789; GO:0005794; GO:0005886; GO:0006915; GO:0008134; GO:0016021; GO:0019901; GO:0030659; GO:0032092; GO:0032479; GO:0032481; GO:0032608; GO:0033160; GO:0035438; GO:0035458; GO:0042802; GO:0042803; GO:0042993; GO:0045087; GO:0045944; GO:0048471; GO:0051607; GO:0061507; GO:0071360; GO:0071407 0 0 0 PF15009; Q8C1B1 CHOYP_CPIPJ_CPIJ005871.1.1 m.40819 sp CAMP2_MOUSE 51.807 166 79 1 60 225 1283 1447 5.61E-47 169 CAMP2_MOUSE reviewed Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1) Camsap2 Camsap1l1 Kiaa1078 Mus musculus (Mouse) 1461 microtubule cytoskeleton organization [GO:0000226]; neuron projection development [GO:0031175]; regulation of organelle organization [GO:0033043] GO:0000226; GO:0005737; GO:0031175; GO:0033043; GO:0036449; GO:0051011 0 0 0 PF17095;PF11971;PF08683; Q9CZJ2 CHOYP_HSPA12A.25.27 m.65103 sp HS12B_MOUSE 36.234 632 334 15 5 576 61 683 5.61E-124 383 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D0W5 CHOYP_CYPL.1.1 m.25000 sp PPIL1_MOUSE 75.309 162 40 0 4 165 2 163 5.61E-94 272 PPIL1_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase-like 1 (PPIase) (EC 5.2.1.8) (Rotamase PPIL1) Ppil1 Mus musculus (Mouse) 166 mRNA processing [GO:0006397]; protein folding [GO:0006457]; RNA splicing [GO:0008380] GO:0003755; GO:0006397; GO:0006457; GO:0008380; GO:0070062; GO:0071013 0 0 0 PF00160; Q9FLK4 CHOYP_BRAFLDRAFT_278918.1.5 m.13792 sp GSXL8_ARATH 36.896 393 223 12 4 377 10 396 5.61E-62 211 GSXL8_ARATH reviewed Flavin-containing monooxygenase FMO GS-OX-like 8 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 8) At5g61290 MFB13.9 Arabidopsis thaliana (Mouse-ear cress) 461 oxidation-reduction process [GO:0055114] GO:0004497; GO:0004499; GO:0050660; GO:0050661; GO:0055114 0 0 0 PF00743; Q9H1D0 CHOYP_LOC101170293.1.1 m.61735 sp TRPV6_HUMAN 26.37 292 170 13 154 439 155 407 5.61E-10 65.5 TRPV6_HUMAN reviewed Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) TRPV6 ECAC2 Homo sapiens (Human) 765 calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; regulation of calcium ion-dependent exocytosis [GO:0017158] GO:0005262; GO:0005516; GO:0005886; GO:0005887; GO:0006816; GO:0017158; GO:0070062; GO:0070588; GO:1990035 0 0 0 PF00023;PF12796;PF00520; Q9ULI1 CHOYP_K1239.1.3 m.6750 sp NWD2_HUMAN 22.683 1327 871 43 68 1277 26 1314 5.61E-72 269 NWD2_HUMAN reviewed NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 0 0 0 0 0 PF13271; Q9ULJ7 CHOYP_LOC100641396.19.27 m.57917 sp ANR50_HUMAN 32.263 654 367 26 159 780 494 1103 5.61E-57 216 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A2VE52 CHOYP_LOC100187372.1.1 m.18074 sp ORN_BOVIN 61.272 173 67 0 38 210 43 215 5.62E-80 241 ORN_BOVIN reviewed "Oligoribonuclease, mitochondrial (EC 3.1.-.-) (RNA exonuclease 2 homolog) (Small fragment nuclease)" REXO2 Bos taurus (Bovine) 237 nucleic acid phosphodiester bond hydrolysis [GO:0090305] GO:0000175; GO:0003676; GO:0005730; GO:0005739; GO:0005758; GO:0005759; GO:0005925; GO:0090305 0 0 0 PF00929; A5D794 CHOYP_LOC100866049.1.1 m.43779 sp GAPD1_BOVIN 49.55 444 203 6 1191 1616 970 1410 5.62E-131 446 GAPD1_BOVIN reviewed GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Bos taurus (Bovine) 1413 endocytosis [GO:0006897]; regulation of protein transport [GO:0051223]; signal transduction [GO:0007165] GO:0005085; GO:0005096; GO:0005768; GO:0005829; GO:0006897; GO:0007165; GO:0016020; GO:0032794; GO:0051223 0 0 0 PF00616;PF02204; B2IZD3 CHOYP_LOC100370751.2.4 m.55559 sp BDLP_NOSP7 23.554 242 159 5 132 356 65 297 5.62E-07 55.8 BDLP_NOSP7 reviewed Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5) Npun_R6513 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 693 0 GO:0003924; GO:0005525; GO:0005886; GO:0008289; GO:0016021 0 0 0 PF00350; E1BGN7 CHOYP_MB21D1.3.5 m.42920 sp CGAS_BOVIN 23.301 309 173 9 32 318 174 440 5.62E-08 58.5 CGAS_BOVIN reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) MB21D1 Bos taurus (Bovine) 498 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O01367 CHOYP_HOW.5.5 m.58452 sp HOW_DROME 74.479 192 49 0 14 205 77 268 5.62E-98 301 HOW_DROME reviewed Protein held out wings (KH domain protein KH93F) (Protein muscle-specific) (Protein struthio) (Protein wings held out) (Putative RNA-binding protein) (Quaking-related 93F) how KH93F qkr93F stru who CG10293 Drosophila melanogaster (Fruit fly) 405 "apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; axon ensheathment [GO:0008366]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; germ-line stem cell population maintenance [GO:0030718]; glial cell migration [GO:0008347]; mesodermal cell migration [GO:0008078]; mesoderm development [GO:0007498]; muscle attachment [GO:0016203]; muscle cell fate determination [GO:0007521]; muscle organ development [GO:0007517]; oenocyte development [GO:0007438]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of embryonic development [GO:0045995]; regulation of heart contraction [GO:0008016]; regulation of translation [GO:0006417]; sarcomere organization [GO:0045214]; somatic muscle development [GO:0007525]; spermatogonial cell division [GO:0007284]" GO:0000381; GO:0003727; GO:0003729; GO:0003730; GO:0005634; GO:0005737; GO:0006417; GO:0007155; GO:0007284; GO:0007438; GO:0007475; GO:0007498; GO:0007517; GO:0007521; GO:0007525; GO:0008016; GO:0008078; GO:0008347; GO:0008366; GO:0016203; GO:0016477; GO:0030154; GO:0030718; GO:0045214; GO:0045995 0 0 0 PF00013;PF16544; O60858 CHOYP_BRAFLDRAFT_82426.14.20 m.55225 sp TRI13_HUMAN 23.81 189 128 3 89 272 90 267 5.62E-06 52.4 TRI13_HUMAN reviewed E3 ubiquitin-protein ligase TRIM13 (EC 6.3.2.-) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (Ret finger protein 2) (Tripartite motif-containing protein 13) TRIM13 LEU5 RFP2 RNF77 Homo sapiens (Human) 407 anatomical structure morphogenesis [GO:0009653]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; innate immune response [GO:0045087]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell death [GO:0010942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; response to gamma radiation [GO:0010332] GO:0004842; GO:0004871; GO:0005737; GO:0005789; GO:0008270; GO:0009653; GO:0010332; GO:0010942; GO:0016021; GO:0016239; GO:0016874; GO:0030433; GO:0032897; GO:0043123; GO:0043161; GO:0045087; GO:0051092; GO:0051865; GO:0097038; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; P05099 CHOYP_BRAFLDRAFT_234820.1.1 m.63189 sp MATN1_CHICK 39.31 145 85 2 25 169 268 409 5.62E-25 103 MATN1_CHICK reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP Gallus gallus (Chicken) 493 0 GO:0005201; GO:0005509; GO:0005578 0 0 0 PF10393;PF00092; P51661 CHOYP_LOC100374321.1.1 m.49165 sp DHI2_MOUSE 34.694 343 222 2 53 393 13 355 5.62E-65 216 DHI2_MOUSE reviewed Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 2) (11-DH2) (11-beta-HSD2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) Hsd11b2 Hsd11k Mus musculus (Mouse) 386 female pregnancy [GO:0007565]; glucocorticoid metabolic process [GO:0008211]; regulation of blood volume by renal aldosterone [GO:0002017]; response to drug [GO:0042493]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868] GO:0001666; GO:0002017; GO:0003845; GO:0005496; GO:0005783; GO:0007565; GO:0008211; GO:0032094; GO:0032868; GO:0042493; GO:0051287; GO:0051384 0 0 0 PF00106; Q02337 CHOYP_LOC100367071.1.1 m.27695 sp BDH_BOVIN 40.333 300 162 7 67 358 52 342 5.62E-61 202 BDH_BOVIN reviewed "D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH)" BDH1 BDH Bos taurus (Bovine) 344 0 GO:0003858; GO:0005654; GO:0005759; GO:0099617 0 0 0 PF00106; Q0V8R7 CHOYP_BM1_12535.1.1 m.9311 sp NSUN4_BOVIN 36.538 104 60 3 30 130 14 114 5.62E-09 59.3 NSUN4_BOVIN reviewed 5-methylcytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) NSUN4 Bos taurus (Bovine) 384 mature ribosome assembly [GO:0042256]; positive regulation of mitochondrial translation [GO:0070131]; rRNA methylation [GO:0031167] GO:0005762; GO:0008168; GO:0031167; GO:0042256; GO:0070131; GO:0070181 0 0 0 PF01189; Q15276 CHOYP_LOC585032.1.2 m.1235 sp RABE1_HUMAN 35.548 858 412 16 15 799 51 840 5.62E-128 409 RABE1_HUMAN reviewed Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17) RABEP1 RAB5EP RABPT5 RABPT5A Homo sapiens (Human) 862 apoptotic process [GO:0006915]; endocytosis [GO:0006897]; membrane fusion [GO:0061025]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005096; GO:0005768; GO:0005769; GO:0006897; GO:0006915; GO:0015031; GO:0016192; GO:0030139; GO:0042803; GO:0043231; GO:0055037; GO:0061025 0 0 0 PF09311;PF03528; Q24306 CHOYP_AAEL_AAEL009074.2.3 m.25222 sp DIAP1_DROME 39.286 140 65 3 59 179 218 356 5.62E-25 105 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q2HJF3 CHOYP_ORC6.1.1 m.29416 sp ORC6_BOVIN 35.938 256 149 5 1 250 1 247 5.62E-42 147 ORC6_BOVIN reviewed Origin recognition complex subunit 6 ORC6 ORC6L Bos taurus (Bovine) 252 DNA replication [GO:0006260] GO:0003677; GO:0005664; GO:0006260; GO:0015629; GO:0016020; GO:0016235 0 0 0 PF05460; Q2TA49 CHOYP_VASP.1.1 m.15245 sp VASP_BOVIN 38.575 407 213 11 43 441 3 380 5.62E-60 203 VASP_BOVIN reviewed Vasodilator-stimulated phosphoprotein (VASP) VASP Bos taurus (Bovine) 383 actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289] GO:0001843; GO:0005737; GO:0005856; GO:0005923; GO:0005925; GO:0007411; GO:0008154; GO:0030838; GO:0031258; GO:0031527; GO:0051289; GO:0070062 0 0 0 PF08776;PF00568; Q496A3 CHOYP_LOC100374662.3.6 m.20284 sp SPAS1_HUMAN 34.682 173 81 3 107 273 142 288 5.62E-17 82.4 SPAS1_HUMAN reviewed Spermatogenesis-associated serine-rich protein 1 SPATS1 Homo sapiens (Human) 300 0 0 0 0 0 PF15160; Q5EAC2 CHOYP_GSHB.1.1 m.27512 sp GSHB_BOVIN 44.885 479 248 5 11 488 11 474 5.62E-135 401 GSHB_BOVIN reviewed Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase) GSS Bos taurus (Bovine) 474 0 GO:0000287; GO:0004363; GO:0005524; GO:0042803; GO:0043295 PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. 0 0 PF03917;PF03199; Q62288 CHOYP_ISCW_ISCW018858.1.1 m.63224 sp TICN1_MOUSE 40.609 197 94 7 206 389 193 379 5.62E-33 131 TICN1_MOUSE reviewed Testican-1 (Protein SPOCK) Spock1 Spock Ticn1 Mus musculus (Mouse) 442 central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of neuron projection development [GO:0010977]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; signal transduction [GO:0007165] GO:0001764; GO:0004869; GO:0005509; GO:0005578; GO:0005615; GO:0005737; GO:0007165; GO:0008191; GO:0010812; GO:0010951; GO:0010977; GO:0016528; GO:0021953; GO:0022008; GO:0031594; GO:0033268 0 0 0 PF07648;PF10591;PF00086; Q6PUR6 CHOYP_BRAFLDRAFT_83096.1.1 m.27012 sp GPN2_DANRE 58.475 118 49 0 1 118 188 305 5.62E-45 150 GPN2_DANRE reviewed GPN-loop GTPase 2 (ATP-binding domain 1 family member B) gpn2 atpbd1b zgc:92877 Danio rerio (Zebrafish) (Brachydanio rerio) 311 0 GO:0005525; GO:0016787 0 0 0 PF03029; Q6RG77 CHOYP_NFYB.1.2 m.8661 sp NFYB_HORSE 58.621 203 76 4 2 198 6 206 5.62E-74 224 NFYB_HORSE reviewed Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) NFYB Equus caballus (Horse) 207 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0043565 0 0 0 PF00808; Q8NB50 CHOYP_LOC100536072.1.1 m.18278 sp ZFP62_HUMAN 27.46 437 280 10 523 946 255 667 5.62E-36 151 ZFP62_HUMAN reviewed Zinc finger protein 62 homolog (Zfp-62) ZFP62 Homo sapiens (Human) 900 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q9BU19 CHOYP_BRAFLDRAFT_67258.9.18 m.34120 sp ZN692_HUMAN 44.231 52 29 0 19 70 13 64 5.62E-06 52.4 ZN692_HUMAN reviewed Zinc finger protein 692 ZNF692 Homo sapiens (Human) 519 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q9NUV9 CHOYP_LOC100147160.1.1 m.62054 sp GIMA4_HUMAN 38.745 271 159 2 108 373 27 295 5.62E-63 209 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; A2VDC2 CHOYP_LOC100690782.1.1 m.26094 sp HIBCH_XENLA 63.934 366 128 1 63 428 17 378 5.63E-172 489 HIBCH_XENLA reviewed "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC 3.1.2.4) (3-hydroxyisobutyryl-coenzyme A hydrolase) (HIB-CoA hydrolase) (HIBYL-CoA-H)" hibch Xenopus laevis (African clawed frog) 385 branched-chain amino acid catabolic process [GO:0009083]; valine catabolic process [GO:0006574] GO:0003860; GO:0005739; GO:0006574; GO:0009083 PATHWAY: Amino-acid degradation; L-valine degradation. 0 0 PF16113; A8J4S9 CHOYP_LOC580425.1.1 m.35215 sp TREA_APIME 43.44 564 312 3 3 560 13 575 5.63E-164 485 TREA_APIME reviewed "Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)" 0 Apis mellifera (Honeybee) 626 trehalose metabolic process [GO:0005991] GO:0004555; GO:0005991; GO:0016021 0 0 0 PF01204; H2A0L1 CHOYP_TYRO2.2.5 m.18429 sp TYRO2_PINMG 39.943 353 178 12 65 389 55 401 5.63E-62 220 TYRO2_PINMG reviewed Tyrosinase-like protein 2 (EC 1.14.18.-) (Tyrosinase 2) 0 Pinctada margaritifera (Black-lipped pearl oyster) 456 0 GO:0005576; GO:0016491; GO:0046872 0 0 0 PF00264; P04323 CHOYP_contig_040048 m.45313 sp POL3_DROME 35.656 244 148 5 93 331 147 386 5.63E-35 138 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P50591 CHOYP_TNF11.1.3 m.48769 sp TNF10_HUMAN 35.772 123 75 3 224 345 162 281 5.63E-19 89 TNF10_HUMAN reviewed Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) TNFSF10 APO2L TRAIL Homo sapiens (Human) 281 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; cell surface receptor signaling pathway [GO:0007166]; immune response [GO:0006955]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; signal transduction [GO:0007165] GO:0005102; GO:0005576; GO:0005615; GO:0005887; GO:0006915; GO:0006919; GO:0006955; GO:0007165; GO:0007166; GO:0007267; GO:0043065; GO:0043123; GO:0043280; GO:0046872; GO:0070062; GO:0090200; GO:0097296; GO:1902041; GO:1902042; GO:2001238 0 0 0 PF00229; Q5XIG6 CHOYP_GALK2.1.2 m.5222 sp GALK2_RAT 57.528 445 187 2 17 461 14 456 5.63E-180 514 GALK2_RAT reviewed N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2) Galk2 Rattus norvegicus (Rat) 458 galactose metabolic process [GO:0006012] GO:0004335; GO:0005524; GO:0005737; GO:0006012; GO:0033858 0 0 0 PF10509;PF08544;PF00288; Q6MG82 CHOYP_LOC100557152.3.3 m.66083 sp PRRT1_RAT 42.466 73 42 0 90 162 221 293 5.63E-13 68.2 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6P5F6 CHOYP_SLC39A10.1.1 m.24529 sp S39AA_MOUSE 33.514 555 243 17 84 519 283 830 5.63E-75 256 S39AA_MOUSE reviewed Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) Slc39a10 Kiaa1265 Zip10 Mus musculus (Mouse) 833 cellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; zinc II ion transmembrane import [GO:0071578] GO:0002903; GO:0005385; GO:0005886; GO:0005887; GO:0006882; GO:0030890; GO:0050861; GO:0071578; GO:1903615 0 0 0 PF02535; Q7Z0T3 CHOYP_TEMPT.1.3 m.4934 sp TEMPT_APLCA 54.369 103 44 3 13 113 19 120 5.63E-28 102 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q7Z2W7 CHOYP_TRPM6.1.2 m.31867 sp TRPM8_HUMAN 25.956 497 296 15 564 1023 561 1022 5.63E-40 165 TRPM8_HUMAN reviewed Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) 1104 calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955] GO:0005262; GO:0005789; GO:0005886; GO:0006874; GO:0009409; GO:0009897; GO:0016021; GO:0016048; GO:0045121; GO:0050955; GO:0051289; GO:0070207; GO:0070588 0 0 0 PF00520; Q8WTR2 CHOYP_LOC100366822.1.1 m.26604 sp DUS19_HUMAN 46.154 195 104 1 5 198 8 202 5.63E-56 179 DUS19_HUMAN reviewed Dual specificity protein phosphatase 19 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase TS-DSP1) (Low molecular weight dual specificity phosphatase 3) (LMW-DSP3) (Protein phosphatase SKRP1) (Stress-activated protein kinase pathway-regulating phosphatase 1) (SAPK pathway-regulating phosphatase 1) DUSP19 DUSP17 LMWDSP3 SKRP1 Homo sapiens (Human) 217 negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase activity [GO:0045860] GO:0004725; GO:0004860; GO:0005078; GO:0006469; GO:0008579; GO:0030295; GO:0031435; GO:0043410; GO:0043507; GO:0043508; GO:0045860; GO:0046329; GO:0046330 0 0 0 PF00782; Q9ESN6 CHOYP_DDB_G0289647.1.1 m.3938 sp TRIM2_MOUSE 25.683 183 121 8 75 252 535 707 5.63E-08 56.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y6R7 CHOYP_BRAFLDRAFT_122634.2.2 m.43678 sp FCGBP_HUMAN 23.429 350 243 11 13 348 89 427 5.63E-11 67.8 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A1L237 CHOYP_ENDUA.1.1 m.30689 sp ENDUA_DANRE 41.489 282 151 7 26 297 22 299 5.64E-61 199 ENDUA_DANRE reviewed Poly(U)-specific endoribonuclease-A (EC 3.1.-.-) (Protein endoU-A) (Uridylate-specific endoribonuclease-A) endoua zgc:158628 Danio rerio (Zebrafish) (Brachydanio rerio) 303 0 GO:0003723; GO:0004521; GO:0005576; GO:0046872 0 0 0 PF09412; A4IF63 CHOYP_BRAFLDRAFT_69647.5.5 m.60362 sp TRIM2_BOVIN 37.549 253 153 1 136 383 477 729 5.64E-41 157 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A9XE49 CHOYP_IL17L.1.1 m.28877 sp IL17L_CRAGI 100 200 0 0 16 215 1 200 5.64E-149 415 IL17L_CRAGI reviewed Interleukin 17-like protein (CgIL-17) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 200 0 GO:0005576 0 0 0 PF06083; O14522 CHOYP_PTPRK.11.20 m.34318 sp PTPRT_HUMAN 31.412 347 186 10 130 426 712 1056 5.64E-44 169 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O14975 CHOYP_LOC100562367.1.1 m.29665 sp S27A2_HUMAN 39.547 574 331 7 86 655 59 620 5.64E-143 432 S27A2_HUMAN reviewed "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) 620 bile acid biosynthetic process [GO:0006699]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; very long-chain fatty acid catabolic process [GO:0042760] GO:0001561; GO:0001676; GO:0004467; GO:0005102; GO:0005524; GO:0005739; GO:0005778; GO:0005779; GO:0005788; GO:0005789; GO:0006635; GO:0006699; GO:0015245; GO:0019899; GO:0030176; GO:0031957; GO:0042760; GO:0044539; GO:0050197; GO:0070062; GO:0070251; GO:0097089; GO:0102391 0 0 0 PF00501;PF13193; Q02357 CHOYP_LOC583072.21.25 m.56857 sp ANK1_MOUSE 40.191 209 125 0 512 720 217 425 5.64E-37 153 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q07DZ5 CHOYP_CTTB2.1.2 m.1598 sp CTTB2_ORNAN 33.976 415 254 7 10 411 997 1404 5.64E-72 262 CTTB2_ORNAN reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Ornithorhynchus anatinus (Duckbill platypus) 1635 0 GO:0005938; GO:0043197 0 0 0 PF12796;PF09727; Q0IIZ5 CHOYP_KBP.1.1 m.16212 sp KBP_XENTR 42.419 620 299 9 1 573 1 609 5.64E-148 442 KBP_XENTR reviewed KIF1-binding protein Kif1bp kbp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 616 central nervous system projection neuron axonogenesis [GO:0021952]; efferent axon development in posterior lateral line nerve [GO:0048929]; enteric nervous system development [GO:0048484]; microtubule cytoskeleton organization [GO:0000226]; mitochondrial transport [GO:0006839]; nervous system development [GO:0007399]; neuron projection maintenance [GO:1990535] GO:0000226; GO:0005739; GO:0005856; GO:0006839; GO:0007399; GO:0019894; GO:0021952; GO:0048484; GO:0048929; GO:1990535 0 0 0 PF12309; Q14162 CHOYP_LOC100370489.4.4 m.50087 sp SREC_HUMAN 41.667 120 60 5 190 306 300 412 5.64E-15 80.5 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q5UNS9 CHOYP_PXDN.3.5 m.28735 sp COLL7_MIMIV 50 146 67 1 108 247 313 458 5.64E-27 118 COLL7_MIMIV reviewed Collagen-like protein 7 MIMI_L669 Acanthamoeba polyphaga mimivirus (APMV) 1937 0 GO:0019012 0 0 0 PF01391; Q640H3 CHOYP_OTU5B.1.1 m.6211 sp OTU5B_XENLA 46.369 537 225 16 1 504 1 507 5.64E-130 391 OTU5B_XENLA reviewed OTU domain-containing protein 5-B (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA) otud5-b Xenopus laevis (African clawed frog) 518 protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; response to lipopolysaccharide [GO:0032496] GO:0004843; GO:0032496; GO:0070536; GO:0071108 0 0 0 PF02338; Q66IJ4 CHOYP_PIGM.1.1 m.17682 sp PIGM_XENTR 56.01 391 159 5 35 414 21 409 5.64E-146 424 PIGM_XENTR reviewed GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M) pigm TGas014d02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 419 GPI anchor biosynthetic process [GO:0006506] GO:0005789; GO:0006506; GO:0016021; GO:0016758 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF05007; Q6ZWX0 CHOYP_ASTER.2.4 m.2886 sp ASTER_MOUSE 82.243 107 16 2 17 121 1 106 5.64E-59 179 ASTER_MOUSE reviewed Protein Asterix (Protein WDR83OS homolog) Wdr83os Mus musculus (Mouse) 106 0 GO:0016021 0 0 0 PF03669; Q8CFJ7 CHOYP_S2545.1.2 m.2635 sp S2545_MOUSE 40 290 165 5 8 292 2 287 5.64E-62 201 S2545_MOUSE reviewed Solute carrier family 25 member 45 Slc25a45 Mus musculus (Mouse) 288 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q8IDX6 CHOYP_contig_045251 m.52577 sp RBP2A_PLAF7 38.312 154 78 5 172 314 2751 2898 5.64E-09 64.3 RBP2A_PLAF7 reviewed Reticulocyte-binding protein 2 homolog a PF13_0198 Plasmodium falciparum (isolate 3D7) 3130 single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0008201; GO:0016020; GO:0016021; GO:0016337 0 0 0 0 Q8JZL1 CHOYP_IL17RA.1.2 m.50986 sp I17RD_MOUSE 25.581 172 114 5 467 629 351 517 5.64E-10 66.6 I17RD_MOUSE reviewed Interleukin-17 receptor D (IL-17 receptor D) (IL-17RD) (Interleukin-17 receptor-like protein) (Sef homolog) (mSef) Il17rd Il17rlm Sef Mus musculus (Mouse) 738 0 GO:0000139; GO:0005654; GO:0005794; GO:0005887; GO:0030368; GO:0046872 0 0 0 PF16742;PF08357; Q8R5M3 CHOYP_BRAFLDRAFT_91298.1.1 m.43490 sp LRC15_RAT 24.109 589 356 11 7 585 10 517 5.64E-34 140 LRC15_RAT reviewed Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid) (rLib) Lrrc15 Lib Rattus norvegicus (Rat) 578 cell communication [GO:0007154]; cytokine-mediated signaling pathway [GO:0019221]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469] GO:0004860; GO:0005622; GO:0005737; GO:0006469; GO:0007154; GO:0016021; GO:0019221; GO:0046426 0 0 0 PF00560;PF13855; Q92851 CHOYP_CASP10.2.7 m.34061 sp CASPA_HUMAN 35.507 138 70 6 7 140 280 402 5.64E-15 78.2 CASPA_HUMAN reviewed Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005829; GO:0006915; GO:0007166; GO:0008625; GO:0030225; GO:0031265; GO:0031625; GO:0035877; GO:0042981; GO:0043123; GO:0097190; GO:0097199; GO:0097342 0 0 0 PF01335; Q96T60 CHOYP_LOC586494.1.1 m.50214 sp PNKP_HUMAN 43.75 352 195 3 85 434 153 503 5.64E-95 299 PNKP_HUMAN reviewed Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] PNKP Homo sapiens (Human) 521 "dephosphorylation [GO:0016311]; DNA 3' dephosphorylation involved in DNA repair [GO:0098504]; DNA damage response, detection of DNA damage [GO:0042769]; DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; nucleotide-excision repair, DNA damage removal [GO:0000718]; nucleotide phosphorylation [GO:0046939]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]" GO:0000718; GO:0003684; GO:0003690; GO:0004519; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006261; GO:0006281; GO:0006979; GO:0009314; GO:0016020; GO:0016311; GO:0017076; GO:0019201; GO:0032212; GO:0042769; GO:0046403; GO:0046404; GO:0046939; GO:0051973; GO:0098504; GO:1904355 0 0 0 PF08645; Q9JIP0 CHOYP_BRAFLDRAFT_125475.2.2 m.41911 sp TRPV5_RAT 27.76 317 175 9 26 316 374 662 5.64E-23 103 TRPV5_RAT reviewed Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transporter 2) (CaT2) (Epithelial calcium channel 1) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) Trpv5 Cat2 Ecac Ecac1 Rattus norvegicus (Rat) 723 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; protein tetramerization [GO:0051262] GO:0005262; GO:0005887; GO:0006816; GO:0016324; GO:0051262; GO:0060402 0 0 0 PF12796;PF00520; A8MU46 CHOYP_LOC756222.2.2 m.57673 sp SMTL1_HUMAN 67.416 89 29 0 3 91 358 446 5.65E-40 140 SMTL1_HUMAN reviewed Smoothelin-like protein 1 SMTNL1 Homo sapiens (Human) 457 negative regulation of vasodilation [GO:0045908]; positive regulation of vasoconstriction [GO:0045907] GO:0005634; GO:0005737; GO:0031430; GO:0031674; GO:0043292; GO:0045907; GO:0045908 0 0 0 PF00307; F7H9X2 CHOYP_TRIM2.44.59 m.48578 sp TRIM2_CALJA 25.714 210 141 4 375 581 544 741 5.65E-17 88.2 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P10632 CHOYP_CP2J6.1.1 m.48635 sp CP2C8_HUMAN 37.161 479 297 1 1 475 1 479 5.65E-116 353 CP2C8_HUMAN reviewed Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) CYP2C8 Homo sapiens (Human) 490 drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; exogenous drug catabolic process [GO:0042738]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; oxidation-reduction process [GO:0055114]; oxidative demethylation [GO:0070989]; xenobiotic metabolic process [GO:0006805] GO:0004497; GO:0005506; GO:0005789; GO:0006082; GO:0006805; GO:0008392; GO:0008395; GO:0017144; GO:0019373; GO:0019825; GO:0020037; GO:0031090; GO:0034875; GO:0042738; GO:0055114; GO:0070330; GO:0070989; GO:0097267 0 0 0 PF00067; P86854 CHOYP_LOC100372505.2.2 m.26614 sp PLCL_MYTGA 31.298 131 84 4 60 188 30 156 5.65E-14 69.7 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q00960 CHOYP_LOC100533244.2.3 m.33391 sp NMDE2_RAT 26.88 532 328 19 4 529 77 553 5.65E-49 185 NMDE2_RAT reviewed "Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)" Grin2b Rattus norvegicus (Rat) 1482 action potential [GO:0001508]; associative learning [GO:0008306]; cellular response to amino acid stimulus [GO:0071230]; cellular response to dsRNA [GO:0071359]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lipid [GO:0071396]; cellular response to magnesium starvation [GO:0010350]; cellular response to manganese ion [GO:0071287]; cellular response to organic cyclic compound [GO:0071407]; cerebral cortex development [GO:0021987]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; memory [GO:0007613]; multicellular organismal response to stress [GO:0033555]; positive regulation of cell death [GO:0010942]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of synaptic transmission [GO:0050806]; receptor clustering [GO:0043113]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of MAPK cascade [GO:0043408]; response to amine [GO:0014075]; response to amphetamine [GO:0001975]; response to calcium ion [GO:0051592]; response to carbohydrate [GO:0009743]; response to cocaine [GO:0042220]; response to cytokine [GO:0034097]; response to electrical stimulus [GO:0051602]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; response to growth hormone [GO:0060416]; response to magnesium ion [GO:0032026]; response to manganese ion [GO:0010042]; response to mechanical stimulus [GO:0009612]; response to methylmercury [GO:0051597]; response to organic cyclic compound [GO:0014070]; response to other organism [GO:0051707]; response to toxic substance [GO:0009636]; rhythmic process [GO:0048511] GO:0001508; GO:0001975; GO:0004970; GO:0004972; GO:0005102; GO:0005149; GO:0005234; GO:0007611; GO:0007613; GO:0007616; GO:0008013; GO:0008144; GO:0008270; GO:0008306; GO:0009612; GO:0009636; GO:0009743; GO:0010042; GO:0010350; GO:0010942; GO:0014049; GO:0014069; GO:0014070; GO:0014075; GO:0017146; GO:0021766; GO:0021987; GO:0030018; GO:0030054; GO:0031749; GO:0032026; GO:0033555; GO:0034097; GO:0035235; GO:0035255; GO:0042165; GO:0042220; GO:0042734; GO:0043005; GO:0043083; GO:0043113; GO:0043195; GO:0043197; GO:0043408; GO:0045202; GO:0045211; GO:0045471; GO:0046982; GO:0048169; GO:0048511; GO:0050806; GO:0050839; GO:0051592; GO:0051597; GO:0051602; GO:0051707; GO:0060416; GO:0060992; GO:0071230; GO:0071287; GO:0071359; GO:0071363; GO:0071396; GO:0071407 0 0 0 PF01094;PF00060;PF10613;PF10565; Q02543 CHOYP_RL18A.5.8 m.44787 sp RL18A_HUMAN 73.95 119 31 0 1 119 54 172 5.65E-62 193 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q14191 CHOYP_BRAFLDRAFT_72852.2.2 m.60263 sp WRN_HUMAN 41.221 131 64 6 53 180 566 686 5.65E-17 81.6 WRN_HUMAN reviewed "Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)" WRN RECQ3 RECQL2 Homo sapiens (Human) 1432 aging [GO:0007568]; base-excision repair [GO:0006284]; brain development [GO:0007420]; cell aging [GO:0007569]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; multicellular organism aging [GO:0010259]; nucleolus to nucleoplasm transport [GO:0032066]; positive regulation of hydrolase activity [GO:0051345]; protein sumoylation [GO:0016925]; regulation of apoptotic process [GO:0042981]; regulation of growth rate [GO:0040009]; regulation of signal transduction by p53 class mediator [GO:1901796]; replication fork processing [GO:0031297]; replicative cell aging [GO:0001302]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; strand displacement [GO:0000732]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722] GO:0000287; GO:0000403; GO:0000405; GO:0000722; GO:0000723; GO:0000731; GO:0000732; GO:0000784; GO:0001302; GO:0003677; GO:0003678; GO:0003682; GO:0004003; GO:0004386; GO:0004527; GO:0005524; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006302; GO:0006974; GO:0006979; GO:0007420; GO:0007568; GO:0007569; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0010259; GO:0016887; GO:0016925; GO:0030145; GO:0031297; GO:0032066; GO:0032403; GO:0040009; GO:0042803; GO:0042981; GO:0043005; GO:0043138; GO:0043140; GO:0051345; GO:0051880; GO:0071480; GO:1901796 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; Q32L09 CHOYP_CS066.1.3 m.44165 sp RYDEN_BOVIN 36.816 201 104 6 13 191 14 213 5.65E-30 119 RYDEN_BOVIN reviewed Repressor of yield of DENV protein homolog (RyDEN) RYDEN Bos taurus (Bovine) 290 defense response to virus [GO:0051607]; negative regulation of viral genome replication [GO:0045071]; response to interferon-gamma [GO:0034341]; response to type III interferon [GO:0034342]; response to type I interferon [GO:0034340] GO:0003723; GO:0005634; GO:0005737; GO:0034340; GO:0034341; GO:0034342; GO:0045071; GO:0051607 0 0 0 PF15135; Q5BIM1 CHOYP_ZF_BBOX_RING_-1.1.10 m.984 sp TRI45_BOVIN 24.161 298 185 12 18 287 29 313 5.65E-12 69.3 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6P0B1 CHOYP_CELF2.1.4 m.2352 sp CELF2_DANRE 63.934 244 71 6 43 272 22 262 5.65E-105 317 CELF2_DANRE reviewed CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (RNA-binding protein BRUNOL-3) celf2 cugbp2 etr3 Danio rerio (Zebrafish) (Brachydanio rerio) 514 mRNA processing [GO:0006397] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006397 0 0 0 PF00076; Q761V0 CHOYP_LOC100375514.1.6 m.12559 sp SC6A5_MOUSE 39.744 156 92 1 1 156 615 768 5.65E-35 134 SC6A5_MOUSE reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) Slc6a5 Glyt2 Mus musculus (Mouse) 799 "glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]" GO:0005328; GO:0005886; GO:0005887; GO:0015375; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; Q8BWD2 CHOYP_IP6K2.2.2 m.57366 sp IP6K3_MOUSE 29.659 381 215 8 15 346 16 392 5.65E-55 187 IP6K3_MOUSE reviewed Inositol hexakisphosphate kinase 3 (InsP6 kinase 3) (EC 2.7.4.21) (Inositol hexaphosphate kinase 3) Ip6k3 Ihpk3 Mus musculus (Mouse) 396 inositol phosphate biosynthetic process [GO:0032958]; phosphatidylinositol metabolic process [GO:0046488]; protein phosphorylation [GO:0006468] GO:0000831; GO:0000832; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008440; GO:0032958; GO:0046488; GO:0052723; GO:0052724 0 0 0 PF03770; Q8R003 CHOYP_LOC100142119.1.2 m.2339 sp MBNL3_MOUSE 45.045 333 155 11 14 342 9 317 5.65E-83 258 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q8WXR4 CHOYP_BRAFLDRAFT_123397.1.1 m.42218 sp MYO3B_HUMAN 48.363 397 181 3 1 391 744 1122 5.65E-110 369 MYO3B_HUMAN reviewed Myosin-IIIb (EC 2.7.11.1) MYO3B Homo sapiens (Human) 1341 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0003774; GO:0004674; GO:0005524; GO:0005737; GO:0007601; GO:0016459; GO:0050896 0 0 0 PF00612;PF00063;PF00069; Q9BT30 CHOYP_LOC100141950.1.1 m.13542 sp ALKB7_HUMAN 49.741 193 97 0 47 239 15 207 5.65E-66 206 ALKB7_HUMAN reviewed "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11)" ALKBH7 ABH7 SPATA11 UNQ6002/PRO34564 Homo sapiens (Human) 221 cellular response to DNA damage stimulus [GO:0006974]; fatty acid metabolic process [GO:0006631]; regulation of lipid storage [GO:0010883]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445] GO:0005759; GO:0006631; GO:0006974; GO:0010883; GO:0046872; GO:0051213; GO:1902445 0 0 0 PF13532; Q9I8C7 CHOYP_NACHRA5.1.2 m.35585 sp ACH10_CHICK 48.525 305 151 4 4 306 57 357 5.65E-105 321 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9JID1 CHOYP_LOC100370909.1.1 m.30849 sp PDCD4_RAT 49.157 415 196 5 120 524 56 465 5.65E-115 351 PDCD4_RAT reviewed Programmed cell death protein 4 (Death up-regulated gene protein) Pdcd4 Dug Rattus norvegicus (Rat) 469 "apoptotic process [GO:0006915]; cell aging [GO:0007569]; negative regulation of apoptotic process [GO:0043066]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; regulation of protein metabolic process [GO:0051246]" GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006915; GO:0007569; GO:0034393; GO:0043066; GO:0043508; GO:0045892; GO:0051246; GO:1904761 0 0 0 PF02847; Q9JK81 CHOYP_LOC100698240.4.4 m.18890 sp MYG1_MOUSE 57.447 141 56 2 19 155 15 155 5.65E-45 156 MYG1_MOUSE reviewed "UPF0160 protein MYG1, mitochondrial (Protein Gamm1)" Myg1 Mus musculus (Mouse) 380 locomotory exploration behavior [GO:0035641] GO:0005634; GO:0005654; GO:0005739; GO:0035641; GO:0070062 0 0 0 PF03690; Q9NYL5 CHOYP_BRAFLDRAFT_83728.1.1 m.41813 sp CP39A_HUMAN 41.535 443 250 5 67 503 29 468 5.65E-128 383 CP39A_HUMAN reviewed 24-hydroxycholesterol 7-alpha-hydroxylase (EC 1.14.14.26) (Cytochrome P450 39A1) (hCYP39A1) (Oxysterol 7-alpha-hydroxylase) CYP39A1 Homo sapiens (Human) 469 bile acid biosynthetic process [GO:0006699]; bile acid catabolic process [GO:0030573]; cholesterol catabolic process [GO:0006707]; digestion [GO:0007586]; sterol metabolic process [GO:0016125] GO:0005506; GO:0005789; GO:0006699; GO:0006707; GO:0007586; GO:0008387; GO:0008396; GO:0016125; GO:0020037; GO:0030573; GO:0031090; GO:0043231 0 0 0 PF00067; Q9Y519 CHOYP_T184B.1.1 m.61143 sp T184B_HUMAN 60.674 445 129 7 18 455 2 407 5.65E-180 511 T184B_HUMAN reviewed Transmembrane protein 184B (Putative MAPK-activating protein FM08) TMEM184B C22orf5 PSEC0108 Homo sapiens (Human) 407 transport [GO:0006810] GO:0005215; GO:0006810; GO:0016021 0 0 0 PF03619; B3EWY9 CHOYP_BRAFLDRAFT_92365.3.3 m.51160 sp MLP_ACRMI 26.833 723 428 27 805 1468 387 1067 5.66E-47 189 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B7Q2M2 CHOYP_RU1C.2.2 m.59192 sp RU1C_IXOSC 73.626 91 24 0 3 93 11 101 5.66E-46 149 RU1C_IXOSC reviewed U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) ISCW020627 Ixodes scapularis (Black-legged tick) (Deer tick) 150 mRNA 5'-splice site recognition [GO:0000395]; spliceosomal snRNP assembly [GO:0000387] GO:0000243; GO:0000387; GO:0000395; GO:0003729; GO:0005685; GO:0008270; GO:0030619; GO:0030627; GO:0071004; GO:0071010 0 0 0 PF06220; O01666 CHOYP_ATP5C1.1.1 m.16222 sp ATPG_DROME 55.797 276 117 3 15 286 22 296 5.66E-105 310 ATPG_DROME reviewed "ATP synthase subunit gamma, mitochondrial (F-ATPase gamma subunit)" ATPsyngamma ATPsyn-gamma CG7610 Drosophila melanogaster (Fruit fly) 297 ATP synthesis coupled proton transport [GO:0015986]; phagocytosis [GO:0006909] GO:0005739; GO:0005743; GO:0005811; GO:0006909; GO:0015986; GO:0045261; GO:0046933; GO:0046961 0 0 cd12151; PF00231; O15050 CHOYP_BRAFLDRAFT_118709.1.4 m.35636 sp TRNK1_HUMAN 30.216 1294 720 28 340 1488 751 2006 5.66E-157 548 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 P10079 CHOYP_LOC100632098.3.13 m.13060 sp FBP1_STRPU 53.316 392 183 0 2 393 189 580 5.66E-132 407 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P53683 CHOYP_AGAP_AGAP002350.1.1 m.37287 sp CDPKJ_ORYSJ 33.333 141 91 3 19 159 394 531 5.66E-13 70.5 CDPKJ_ORYSJ reviewed Calcium-dependent protein kinase 19 (OsCDPK19) (OsCPK19) (EC 2.7.11.1) (Calcium-dependent protein kinase isoform 2) (OsCDPK2) (OsCPK2) CPK19 CPK2 Os07g0515100 LOC_Os07g33110 P0048D08.112 Oryza sativa subsp. japonica (Rice) 533 abscisic acid-activated signaling pathway [GO:0009738]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0009738; GO:0009931; GO:0016020; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; Q00PJ9 CHOYP_BRAFLDRAFT_68444.4.4 m.56117 sp CAV1_ATEAB 39.231 130 78 1 2 130 43 172 5.66E-29 106 CAV1_ATEAB reviewed Caveolin-1 CAV1 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) 178 caveola assembly [GO:0070836]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; receptor internalization [GO:0031623]; T cell costimulation [GO:0031295] GO:0000139; GO:0005768; GO:0005901; GO:0030512; GO:0031295; GO:0031623; GO:0045121; GO:0070836 0 0 0 PF01146; Q15431 CHOYP_USO1.8.11 m.46032 sp SYCP1_HUMAN 27.701 722 413 20 67 765 97 732 5.66E-27 122 SYCP1_HUMAN reviewed Synaptonemal complex protein 1 (SCP-1) (Cancer/testis antigen 8) (CT8) SYCP1 SCP1 Homo sapiens (Human) 976 cell division [GO:0051301]; chiasma assembly [GO:0051026]; lateral element assembly [GO:0051878]; meiotic DNA repair synthesis [GO:0000711]; reciprocal meiotic recombination [GO:0007131]; regulation of protein localization [GO:0032880]; spermatogenesis [GO:0007283]; sperm chromatin condensation [GO:0035092]; synapsis [GO:0007129]; synaptonemal complex assembly [GO:0007130] GO:0000711; GO:0000775; GO:0000795; GO:0000801; GO:0000802; GO:0001673; GO:0003677; GO:0007129; GO:0007130; GO:0007131; GO:0007283; GO:0032880; GO:0035092; GO:0051026; GO:0051301; GO:0051878 0 0 0 PF05483; Q4R5P1 CHOYP_RAB8A.2.3 m.33866 sp RAB8A_MACFA 84.135 208 31 2 66 272 1 207 5.66E-125 357 RAB8A_MACFA reviewed Ras-related protein Rab-8A RAB8A QccE-11745 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 207 axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0042384]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005794; GO:0005814; GO:0005886; GO:0005929; GO:0007264; GO:0007409; GO:0015031; GO:0017137; GO:0019003; GO:0030670; GO:0032869; GO:0042384; GO:0045335; GO:0055038; GO:0072659 0 0 0 PF00071; Q58D68 CHOYP_ENPP6.3.5 m.13309 sp ENPP6_PIG 36.122 263 154 4 3 261 169 421 5.66E-49 170 ENPP6_PIG reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine cholinephosphodiesterase) (GPC-Cpde) ENPP6 Sus scrofa (Pig) 440 choline metabolic process [GO:0019695]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629] GO:0005886; GO:0006629; GO:0008081; GO:0016042; GO:0019695; GO:0031225; GO:0047390 0 0 0 PF01663; Q7Z2W7 CHOYP_TRPM2.9.12 m.55043 sp TRPM8_HUMAN 26.376 527 310 18 540 1021 530 1023 5.66E-41 167 TRPM8_HUMAN reviewed Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) 1104 calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955] GO:0005262; GO:0005789; GO:0005886; GO:0006874; GO:0009409; GO:0009897; GO:0016021; GO:0016048; GO:0045121; GO:0050955; GO:0051289; GO:0070207; GO:0070588 0 0 0 PF00520; Q96EY1 CHOYP_contig_053846 m.64435 sp DNJA3_HUMAN 42.453 106 52 3 2 98 51 156 5.66E-16 79.3 DNJA3_HUMAN reviewed "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) 480 activation-induced cell death of T cells [GO:0006924]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell aging [GO:0007569]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of programmed cell death [GO:0043069]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to interferon-gamma [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] GO:0000122; GO:0005133; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006264; GO:0006457; GO:0006469; GO:0006919; GO:0006924; GO:0007005; GO:0007264; GO:0007528; GO:0007569; GO:0008134; GO:0008285; GO:0009408; GO:0019897; GO:0019901; GO:0030054; GO:0030695; GO:0031398; GO:0031594; GO:0032088; GO:0033077; GO:0034341; GO:0042102; GO:0042645; GO:0043065; GO:0043066; GO:0043069; GO:0043124; GO:0043154; GO:0043231; GO:0045211; GO:0046872; GO:0050821; GO:0051059; GO:0060336; GO:0071340 0 0 cd06257; PF00226;PF01556;PF00684; Q9BXI9 CHOYP_TMEL_0889.2.2 m.21437 sp C1QT6_HUMAN 32.258 124 77 4 284 406 111 228 5.66E-06 50.8 C1QT6_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 6 C1QTNF6 CTRP6 UNQ581/PRO1151 Homo sapiens (Human) 259 protein heterotrimerization [GO:0070208] GO:0005581; GO:0005615; GO:0070208 0 0 0 PF00386;PF01391; Q9H1D0 CHOYP_IAV.1.1 m.22710 sp TRPV6_HUMAN 27.463 335 215 9 1 314 360 687 5.66E-24 106 TRPV6_HUMAN reviewed Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) TRPV6 ECAC2 Homo sapiens (Human) 765 calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; regulation of calcium ion-dependent exocytosis [GO:0017158] GO:0005262; GO:0005516; GO:0005886; GO:0005887; GO:0006816; GO:0017158; GO:0070062; GO:0070588; GO:1990035 0 0 0 PF00023;PF12796;PF00520; Q9H6P5 CHOYP_TASP1.1.1 m.14338 sp TASP1_HUMAN 43.467 375 192 5 5 366 43 410 5.66E-96 295 TASP1_HUMAN reviewed Threonine aspartase 1 (Taspase-1) (EC 3.4.25.-) [Cleaved into: Threonine aspartase subunit alpha; Threonine aspartase subunit beta] TASP1 C20orf13 Homo sapiens (Human) 420 "positive regulation of transcription, DNA-templated [GO:0045893]; proteolysis [GO:0006508]" GO:0004298; GO:0006508; GO:0045893 0 0 0 PF01112; A0JPP8 CHOYP_LOC100373421.1.1 m.38932 sp CCD61_RAT 47.912 407 164 9 1 407 1 359 5.67E-111 343 CCD61_RAT reviewed Coiled-coil domain-containing protein 61 Ccdc61 Rattus norvegicus (Rat) 512 0 GO:0005813 0 0 0 0 B0BNA9 CHOYP_LOC100561785.1.1 m.10326 sp CNO11_RAT 52.206 136 62 2 1 133 55 190 5.67E-42 148 CNO11_RAT reviewed CCR4-NOT transcription complex subunit 11 Cnot11 Rattus norvegicus (Rat) 504 "gene silencing by RNA [GO:0031047]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006417; GO:0030014; GO:0031047 0 0 0 PF10155; P22770 CHOYP_AGAP_AGAP002152.1.1 m.45611 sp ACHA7_CHICK 45.534 459 208 6 23 451 18 464 5.67E-137 405 ACHA7_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 Gallus gallus (Chicken) 502 "activation of MAPK activity [GO:0000187]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; cognition [GO:0050890]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell proliferation [GO:0008284]; response to hypoxia [GO:0001666]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0000187; GO:0001540; GO:0001666; GO:0004889; GO:0005737; GO:0005886; GO:0005892; GO:0006816; GO:0006874; GO:0007165; GO:0007271; GO:0008284; GO:0015464; GO:0015643; GO:0017081; GO:0030054; GO:0030424; GO:0030425; GO:0032720; GO:0035094; GO:0042166; GO:0042803; GO:0043204; GO:0045211; GO:0045766; GO:0050890 0 0 0 PF02931;PF02932; P35129 CHOYP_UBC2.3.3 m.66222 sp UBC2_CAEEL 91.837 147 12 0 44 190 1 147 5.67E-99 285 UBC2_CAEEL reviewed Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Lethal protein 70) (Ubiquitin carrier protein 2) (Ubiquitin-protein ligase 2) let-70 ubc-2 M7.1 Caenorhabditis elegans 147 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005524; GO:0016567; GO:0031625; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; P46939 CHOYP_TEKT5.1.1 m.60032 sp UTRO_HUMAN 25.94 266 178 3 13 267 1854 2111 5.67E-25 108 UTRO_HUMAN reviewed Utrophin (Dystrophin-related protein 1) (DRP-1) UTRN DMDL DRP1 Homo sapiens (Human) 3433 muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649] GO:0001954; GO:0003779; GO:0005178; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0006936; GO:0007517; GO:0007528; GO:0008270; GO:0016010; GO:0016020; GO:0017166; GO:0019901; GO:0030054; GO:0030175; GO:0030426; GO:0030864; GO:0031527; GO:0031594; GO:0042383; GO:0043234; GO:0045211; GO:0070062; GO:2000649 0 0 0 PF00307;PF09068;PF09069;PF00435;PF00569; P56597 CHOYP_LOC100371808.1.2 m.15364 sp NDK5_HUMAN 63.871 155 56 0 2 156 24 178 5.67E-76 229 NDK5_HUMAN reviewed Nucleoside diphosphate kinase homolog 5 (NDK-H 5) (NDP kinase homolog 5) (Inhibitor of p53-induced apoptosis-beta) (IPIA-beta) (Testis-specific nm23 homolog) (nm23-H5) NME5 Homo sapiens (Human) 212 cilium assembly [GO:0042384]; CTP biosynthetic process [GO:0006241]; epithelial cilium movement [GO:0003351]; GTP biosynthetic process [GO:0006183]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; nucleoside metabolic process [GO:0009116]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; UTP biosynthetic process [GO:0006228]; ventricular system development [GO:0021591] GO:0003351; GO:0004550; GO:0005622; GO:0006183; GO:0006228; GO:0006241; GO:0007283; GO:0007286; GO:0009116; GO:0021591; GO:0036126; GO:0042384; GO:1902176 0 0 0 PF05186;PF00334; P57760 CHOYP_LOC100745596.1.1 m.9791 sp STK16_RAT 41.391 302 163 5 10 308 1 291 5.67E-85 261 STK16_RAT reviewed Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) Stk16 Mpsk1 Tsf1 Rattus norvegicus (Rat) 305 cellular response to transforming growth factor beta stimulus [GO:0071560]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777] GO:0001077; GO:0004672; GO:0004674; GO:0004715; GO:0005524; GO:0005737; GO:0005798; GO:0016020; GO:0045944; GO:0046777; GO:0048471; GO:0071560 0 0 0 PF00069; Q09624 CHOYP_LOC100368614.1.3 m.31897 sp PKD1_CAEEL 25.043 1154 738 26 2362 3469 2171 3243 5.67E-101 370 PKD1_CAEEL reviewed Location of vulva defective 1 (Polycystic kidney disease 1 protein homolog) (Polycystin-1) lov-1 pkd-1 ZK945.9/ZK945.10 Caenorhabditis elegans 3284 detection of mechanical stimulus [GO:0050982]; male mating behavior [GO:0060179]; mating behavior [GO:0007617]; response to hermaphrodite contact [GO:0034606]; vulval location [GO:0034608] GO:0005262; GO:0005929; GO:0007617; GO:0016020; GO:0016021; GO:0019904; GO:0031513; GO:0034606; GO:0034608; GO:0043025; GO:0050982; GO:0060179 0 0 0 PF08016;PF01477; Q28IU1 CHOYP_DHB12.1.1 m.62534 sp DHB12_XENTR 51.974 304 145 1 34 336 17 320 5.67E-105 313 DHB12_XENTR reviewed Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) hsd17b12 TNeu053h21.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 320 estrogen biosynthetic process [GO:0006703]; fatty acid biosynthetic process [GO:0006633]; steroid biosynthetic process [GO:0006694] GO:0004303; GO:0005789; GO:0006633; GO:0006694; GO:0006703; GO:0016021; GO:0102339; GO:0102340; GO:0102341 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q53GQ0}.; PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000250|UniProtKB:Q53GQ0}. 0 0 PF00106; Q2YDJ8 CHOYP_LOC100891939.1.7 m.8031 sp KMT5A_BOVIN 32.54 126 66 4 65 173 226 349 5.67E-14 72.4 KMT5A_BOVIN reviewed N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.43) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8) KMT5A SETD8 Bos taurus (Bovine) 352 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; peptidyl-lysine monomethylation [GO:0018026]; regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002039; GO:0005634; GO:0005694; GO:0006351; GO:0007067; GO:0016279; GO:0018024; GO:0018026; GO:0043516; GO:0051301 0 0 0 PF00856; Q5EAR5 CHOYP_LOC100186294.1.2 m.39156 sp TRPT1_DANRE 50.244 205 95 4 198 398 23 224 5.67E-62 211 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q5GRG2 CHOYP_NLGN2.1.3 m.4279 sp EST5A_RAT 32.288 542 324 12 102 629 35 547 5.67E-77 260 EST5A_RAT reviewed Carboxylesterase 5A (EC 3.1.1.1) (Carboxylesterase-like urinary excreted protein homolog) (Cauxin) (Epididymis-specific gene 615 protein) Ces5a Ces7 Rattus norvegicus (Rat) 575 0 GO:0005615; GO:0052689 0 0 0 PF00135; Q5R592 CHOYP_RPAB2.1.2 m.1204 sp RPAB2_PONAB 75.701 107 23 2 41 146 22 126 5.67E-52 164 RPAB2_PONAB reviewed "DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (RPB6 homolog)" POLR2F Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 127 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005634; GO:0005665; GO:0006366 0 0 0 PF01192; Q62685 CHOYP_LOC100120260.1.1 m.41888 sp NR1H3_RAT 31.436 369 218 11 95 445 93 444 5.67E-47 171 NR1H3_RAT reviewed Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) (RLD-1) Nr1h3 Lxra Rattus norvegicus (Rat) 445 "insulin receptor signaling pathway [GO:0008286]; lipid metabolic process [GO:0006629]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cholesterol homeostasis [GO:2000188]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0005737; GO:0006351; GO:0006629; GO:0008270; GO:0008286; GO:0043565; GO:0045893; GO:0046965; GO:0046982; GO:2000188 0 0 0 PF00104;PF00105; Q6DCF6 CHOYP_EFCAB7.1.1 m.17862 sp EFCB7_XENLA 37.336 608 352 12 17 615 31 618 5.67E-131 400 EFCB7_XENLA reviewed EF-hand calcium-binding domain-containing protein 7 efcab7 Xenopus laevis (African clawed frog) 620 0 GO:0005509 0 0 0 PF13202;PF13499; Q6Q899 CHOYP_DDX58.8.9 m.61410 sp DDX58_MOUSE 30.769 728 447 20 375 1073 212 911 5.67E-84 296 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q96MM6 CHOYP_BRAFLDRAFT_208197.19.21 m.60089 sp HS12B_HUMAN 31.201 641 344 21 233 794 61 683 5.67E-81 277 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9CQR7 CHOYP_PHUM_PHUM285270.1.1 m.57612 sp PEN2_MOUSE 59.406 101 41 0 1 101 1 101 5.67E-41 133 PEN2_MOUSE reviewed Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2) Psenen Pen2 Mus musculus (Mouse) 101 membrane protein ectodomain proteolysis [GO:0006509]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; positive regulation of catalytic activity [GO:0043085]; protein processing [GO:0016485] GO:0005783; GO:0005789; GO:0005794; GO:0005886; GO:0005887; GO:0006509; GO:0007219; GO:0007220; GO:0016485; GO:0043085; GO:0070765 0 0 0 PF10251; Q9GUM2 CHOYP_PHUM_PHUM125800.2.2 m.59389 sp BRE4_CAEEL 45.415 229 121 2 83 307 136 364 5.67E-66 214 BRE4_CAEEL reviewed "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 Y73E7A.7 Caenorhabditis elegans 383 formation of infection structure on or near host [GO:0075015]; positive regulation of Notch signaling pathway [GO:0045747]; protein glycosylation [GO:0006486]; response to toxic substance [GO:0009636] GO:0006486; GO:0008376; GO:0009636; GO:0016021; GO:0033207; GO:0045747; GO:0046872; GO:0075015 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:12167666, ECO:0000269|PubMed:12944392}." 0 0 PF02709;PF13733; Q9H8W5 CHOYP_TRI45.1.23 m.562 sp TRI45_HUMAN 27.586 203 123 5 27 214 27 220 5.67E-13 70.5 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9JHG0 CHOYP_CBLN9.1.1 m.4569 sp CBLN3_MOUSE 32.479 117 68 3 94 205 84 194 5.67E-08 54.3 CBLN3_MOUSE reviewed Cerebellin-3 Cbln3 Mus musculus (Mouse) 197 0 GO:0005615; GO:0005783; GO:0005794; GO:0030054; GO:0045202 0 0 0 PF00386; Q9UGM3 CHOYP_LOC100638486.1.1 m.1134 sp DMBT1_HUMAN 44.811 212 107 6 84 289 494 701 5.67E-39 161 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A4IF63 CHOYP_BRAFLDRAFT_87279.6.10 m.32968 sp TRIM2_BOVIN 26.207 145 93 4 17 157 609 743 5.68E-07 52.8 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_87288.5.5 m.65255 sp TRIM2_BOVIN 27.536 207 130 6 148 342 546 744 5.68E-13 73.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E9QBI7 CHOYP_LOC594646.2.2 m.38865 sp OMA1_DANRE 39.045 356 202 5 75 415 98 453 5.68E-82 263 OMA1_DANRE reviewed "Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Overlapping with the m-AAA protease 1 homolog)" oma1 si:ch73-215a11.1 Danio rerio (Zebrafish) (Brachydanio rerio) 478 diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrial protein processing [GO:0034982]; negative regulation of mitochondrial fusion [GO:0010637]; response to stress [GO:0006950] GO:0002024; GO:0004222; GO:0005743; GO:0006006; GO:0006515; GO:0006629; GO:0006950; GO:0010637; GO:0016021; GO:0031966; GO:0034982; GO:0046872; GO:0097009 0 0 0 PF01435; O43175 CHOYP_LOC590971.1.1 m.30661 sp SERA_HUMAN 59.277 415 159 4 1 412 1 408 5.68E-166 484 SERA_HUMAN reviewed D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) PHGDH PGDH3 Homo sapiens (Human) 533 brain development [GO:0007420]; G1 to G0 transition [GO:0070314]; gamma-aminobutyric acid metabolic process [GO:0009448]; glial cell development [GO:0021782]; glutamine metabolic process [GO:0006541]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; neural tube development [GO:0021915]; neuron projection development [GO:0031175]; regulation of gene expression [GO:0010468]; serine family amino acid biosynthetic process [GO:0009070]; spinal cord development [GO:0021510]; taurine metabolic process [GO:0019530]; threonine metabolic process [GO:0006566] GO:0004617; GO:0005829; GO:0006541; GO:0006544; GO:0006564; GO:0006566; GO:0007420; GO:0009055; GO:0009070; GO:0009448; GO:0010468; GO:0019530; GO:0021510; GO:0021782; GO:0021915; GO:0031175; GO:0043209; GO:0051287; GO:0070062; GO:0070314 PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3. 0 0 PF00389;PF02826; P06731 CHOYP_HMCN1.16.44 m.34860 sp CEAM5_HUMAN 26.154 325 206 15 32 341 202 507 5.68E-16 85.1 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; P29176 CHOYP_contig_050455 m.60030 sp FOSX_MSVFR 33.784 74 49 0 93 166 107 180 5.68E-07 52.8 FOSX_MSVFR reviewed Transforming protein v-Fos/v-Fox FOS-FOX FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus) 244 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0003700; GO:0006357; GO:0042025; GO:0043565 0 0 0 PF00170; P62501 CHOYP_LOC100701007.1.1 m.30190 sp T22D1_RAT 90.164 61 6 0 72 132 44 104 5.68E-31 111 T22D1_RAT reviewed TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) Tsc22d1 Tgfb1i4 Tsc22 Rattus norvegicus (Rat) 143 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351 0 0 0 PF01166; Q02357 CHOYP_contig_042534 m.48999 sp ANK1_MOUSE 42.453 106 61 0 266 371 652 757 5.68E-19 92.4 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q13231 CHOYP_BRAFLDRAFT_281651.7.8 m.47022 sp CHIT1_HUMAN 49.537 432 189 10 38 455 23 439 5.68E-140 412 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q26487 CHOYP_EEF1A.2.3 m.20687 sp EF1A_SPOFR 86.937 222 29 0 1 222 35 256 5.68E-139 399 EF1A_SPOFR reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Spodoptera frugiperda (Fall armyworm) 413 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q28346 CHOYP_RL4B.1.1 m.62934 sp RL4_CANLF 80 190 38 0 1 190 5 194 5.68E-111 327 RL4_CANLF reviewed 60S ribosomal protein L4 (60S ribosomal protein L1) RPL4 RPL1 Canis lupus familiaris (Dog) (Canis familiaris) 421 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF14374;PF00573; Q54468 CHOYP_NEMVEDRAFT_V1G201552.5.6 m.51416 sp CHB_SERMA 38.679 424 205 9 2 386 427 834 5.68E-86 281 CHB_SERMA reviewed Chitobiase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (N-acetyl-beta-glucosaminidase) chb Serratia marcescens 885 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0030247; GO:0042597 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; Q68EV6 CHOYP_LOC101071891.1.2 m.31440 sp RM28_XENLA 47.032 219 107 4 41 257 24 235 5.68E-58 189 RM28_XENLA reviewed "39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28)" mrpl28 Xenopus laevis (African clawed frog) 253 0 GO:0003735; GO:0005739; GO:0005840 0 0 0 PF00830; Q6AXS3 CHOYP_DEK.1.1 m.40646 sp DEK_RAT 43.072 332 179 6 96 424 54 378 5.68E-61 205 DEK_RAT reviewed Protein DEK Dek Rattus norvegicus (Rat) 378 covalent chromatin modification [GO:0016569]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032] GO:0003677; GO:0005634; GO:0016569; GO:0043292; GO:0044822; GO:2001032 0 0 0 PF08766; Q6TLH3 CHOYP_LOC756750.1.1 m.21065 sp CUED2_DANRE 38.849 278 158 4 9 280 6 277 5.68E-53 178 CUED2_DANRE reviewed CUE domain-containing protein 2 cuedc2 zgc:92255 Danio rerio (Zebrafish) (Brachydanio rerio) 282 0 GO:0005634; GO:0005737 0 0 0 0 Q8AWF2 CHOYP_ISCW_ISCW012592.2.2 m.58477 sp NACA_ORENI 58.929 112 33 4 1 104 1 107 5.68E-24 96.7 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q8IIG7 CHOYP_LMXM_36_6480.2.2 m.33820 sp YPF05_PLAF7 21.739 322 239 4 94 414 118 427 5.68E-13 75.5 YPF05_PLAF7 reviewed Uncharacterized protein PF11_0207 PF11_0207 Plasmodium falciparum (isolate 3D7) 1070 0 GO:0005737; GO:0016020 0 0 0 0 Q8IZD4 CHOYP_LOC100554670.1.1 m.4865 sp DCP1B_HUMAN 53.171 205 77 7 16 218 16 203 5.68E-58 205 DCP1B_HUMAN reviewed mRNA-decapping enzyme 1B (EC 3.-.-.-) DCP1B Homo sapiens (Human) 617 "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]" GO:0000184; GO:0000290; GO:0000932; GO:0003729; GO:0005634; GO:0005737; GO:0005829; GO:0008047; GO:0016020; GO:0016787; GO:0030234; GO:0031087; GO:0043231; GO:0043928 0 0 0 PF06058;PF16741; Q8TBK6 CHOYP_BRAFLDRAFT_123288.1.1 m.65665 sp ZCH10_HUMAN 46.774 62 30 1 24 85 31 89 5.68E-11 61.6 ZCH10_HUMAN reviewed Zinc finger CCHC domain-containing protein 10 ZCCHC10 Homo sapiens (Human) 192 0 GO:0003676; GO:0008270 0 0 0 0 Q91ZR3 CHOYP_MYS3.1.2 m.31829 sp ZHANG_MOUSE 43.299 97 49 3 139 230 223 318 5.68E-12 68.9 ZHANG_MOUSE reviewed CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei) (Tyrosine kinase-associated leucine zipper protein LAZip) Crebzf Zf Mus musculus (Mouse) 358 "negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; response to virus [GO:0009615]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0009615; GO:0042802; GO:0043565; GO:0045814; GO:0045892; GO:0051090 0 0 0 PF00170; Q95K40 CHOYP_BRAFLDRAFT_268046.1.3 m.30266 sp CCD83_MACFA 30.526 190 114 4 9 187 3 185 5.68E-13 69.7 CCD83_MACFA reviewed Coiled-coil domain-containing protein 83 CCDC83 QtsA-10152 QtsA-19320 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 413 0 0 0 0 0 0 Q95KL9 CHOYP_LOC100576956.1.1 m.66868 sp TIMP1_MACMU 38.235 68 37 2 1 66 7 71 5.68E-08 51.2 TIMP1_MACMU reviewed Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1) (TIMP-1) TIMP1 Macaca mulatta (Rhesus macaque) 207 negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of trophoblast cell migration [GO:1901164]; positive regulation of cell proliferation [GO:0008284]; regulation of integrin-mediated signaling pathway [GO:2001044]; response to cytokine [GO:0034097]; response to hormone [GO:0009725] GO:0002020; GO:0005125; GO:0005578; GO:0005604; GO:0005615; GO:0008191; GO:0008284; GO:0009725; GO:0010951; GO:0034097; GO:0043086; GO:0046872; GO:0051045; GO:0070062; GO:1901164; GO:2001044 0 0 0 PF00965; Q9GNE2 CHOYP_RL23.9.11 m.49288 sp RL23_AEDAE 90.909 66 6 0 23 88 1 66 5.68E-36 122 RL23_AEDAE reviewed 60S ribosomal protein L23 (AeRpL17A) (L17A) RpL23-A RpL17A AAEL013097; RpL23-B AAEL013583; RpL23-C AAEL015006 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 140 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00238; Q9Y493 CHOYP_CRE_06684.1.1 m.34357 sp ZAN_HUMAN 45.263 95 48 2 101 191 702 796 5.68E-09 61.6 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A0JM12 CHOYP_MEG10.29.91 m.33867 sp MEG10_XENTR 36.218 312 150 15 134 419 373 661 5.69E-32 134 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A4IF63 CHOYP_BN140_2141.1.1 m.20672 sp TRIM2_BOVIN 35.185 108 66 3 22 126 625 731 5.69E-12 65.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14662 CHOYP_LOC100372071.1.1 m.14107 sp STX16_HUMAN 54.777 314 109 4 1 293 1 302 5.69E-115 338 STX16_HUMAN reviewed Syntaxin-16 (Syn16) STX16 Homo sapiens (Human) 325 "Golgi ribbon formation [GO:0090161]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]" GO:0000139; GO:0005484; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0005925; GO:0006886; GO:0006906; GO:0016020; GO:0016021; GO:0019905; GO:0031201; GO:0031985; GO:0032588; GO:0042147; GO:0043231; GO:0048278; GO:0048471; GO:0090161 0 0 0 PF05739;PF00804; O15439 CHOYP_ABCC4.1.1 m.66690 sp MRP4_HUMAN 35.135 148 93 1 8 152 10 157 5.69E-26 105 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; P10632 CHOYP_WNT2B.3.3 m.56273 sp CP2C8_HUMAN 38.446 489 300 1 1 488 1 489 5.69E-125 376 CP2C8_HUMAN reviewed Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) CYP2C8 Homo sapiens (Human) 490 drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; exogenous drug catabolic process [GO:0042738]; omega-hydroxylase P450 pathway [GO:0097267]; organic acid metabolic process [GO:0006082]; oxidation-reduction process [GO:0055114]; oxidative demethylation [GO:0070989]; xenobiotic metabolic process [GO:0006805] GO:0004497; GO:0005506; GO:0005789; GO:0006082; GO:0006805; GO:0008392; GO:0008395; GO:0017144; GO:0019373; GO:0019825; GO:0020037; GO:0031090; GO:0034875; GO:0042738; GO:0055114; GO:0070330; GO:0070989; GO:0097267 0 0 0 PF00067; P14381 CHOYP_LOC100371228.2.4 m.26351 sp YTX2_XENLA 26.633 199 139 5 1 197 1 194 5.69E-13 70.1 YTX2_XENLA reviewed Transposon TX1 uncharacterized 149 kDa protein (ORF 2) 0 Xenopus laevis (African clawed frog) 1308 0 0 0 0 0 PF03372;PF00078; P52732 CHOYP_LOC100372181.1.1 m.30892 sp KIF11_HUMAN 28.676 136 68 5 2 111 18 150 5.69E-07 50.1 KIF11_HUMAN reviewed Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5) KIF11 EG5 KNSL1 TRIP5 Homo sapiens (Human) 1056 "antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; microtubule-based movement [GO:0007018]; mitotic centrosome separation [GO:0007100]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; regulation of mitotic centrosome separation [GO:0046602]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; spindle organization [GO:0007051]" GO:0000922; GO:0003777; GO:0005524; GO:0005737; GO:0005819; GO:0005829; GO:0005871; GO:0005874; GO:0006890; GO:0007018; GO:0007051; GO:0007052; GO:0007059; GO:0007067; GO:0007100; GO:0008574; GO:0016020; GO:0019886; GO:0019901; GO:0032403; GO:0046602; GO:0051301; GO:0090307 0 0 0 PF00225;PF13931; P54813 CHOYP_LOC658809.1.1 m.35059 sp YME1_CAEEL 43.551 597 304 10 151 720 101 691 5.69E-150 456 YME1_CAEEL reviewed ATP-dependent zinc metalloprotease YME1 homolog (EC 3.4.24.-) ymel-1 M03C11.5 Caenorhabditis elegans 723 misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrion organization [GO:0007005] GO:0004176; GO:0004222; GO:0005524; GO:0005743; GO:0006515; GO:0007005; GO:0008237; GO:0016021; GO:0046872 0 0 0 PF00004;PF01434; P61354 CHOYP_PP1B.1.3 m.21710 sp RL27_RAT 82.353 136 24 0 1 136 1 136 5.69E-80 234 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; P86789 CHOYP_BRAFLDRAFT_121480.1.1 m.48790 sp GIGA6_CRAGI 45.055 273 143 4 27 298 11 277 5.69E-77 248 GIGA6_CRAGI reviewed Gigasin-6 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 302 0 GO:0016021 0 0 0 PF00144; Q10741 CHOYP_LOC100117425.1.1 m.1256 sp ADA10_BOVIN 41.362 793 362 22 22 806 24 721 5.69E-179 537 ADA10_BOVIN reviewed Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (Myelin-associated metalloproteinase) (CD antigen CD156c) ADAM10 MADM Bos taurus (Bovine) 748 constitutive protein ectodomain proteolysis [GO:0051089]; in utero embryonic development [GO:0001701]; membrane protein ectodomain proteolysis [GO:0006509]; monocyte activation [GO:0042117]; negative regulation of cell adhesion [GO:0007162]; Notch signaling pathway [GO:0007219]; PMA-inducible membrane protein ectodomain proteolysis [GO:0051088]; positive regulation of cell growth [GO:0030307]; positive regulation of cell proliferation [GO:0008284]; positive regulation of T cell chemotaxis [GO:0010820]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; response to tumor necrosis factor [GO:0034612] GO:0000139; GO:0001701; GO:0004175; GO:0004222; GO:0005634; GO:0005737; GO:0005794; GO:0005798; GO:0005925; GO:0006468; GO:0006509; GO:0007162; GO:0007219; GO:0008237; GO:0008270; GO:0008284; GO:0009986; GO:0010820; GO:0014069; GO:0016021; GO:0016485; GO:0019901; GO:0030307; GO:0034612; GO:0042117; GO:0042803; GO:0051088; GO:0051089; GO:0070062; GO:0097038; GO:0097197 0 0 0 PF00200;PF01562; Q13489 CHOYP_BIRC2.9.13 m.53752 sp BIRC3_HUMAN 38.824 85 42 2 164 248 529 603 5.69E-09 59.7 BIRC3_HUMAN reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 MIHC RNF49 Homo sapiens (Human) 604 cell surface receptor signaling pathway [GO:0007166]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; protein heterooligomerization [GO:0051291]; regulation of apoptotic process [GO:0042981]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; spermatogenesis [GO:0007283]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007166; GO:0007249; GO:0007283; GO:0008270; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0031398; GO:0033209; GO:0034121; GO:0035666; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043234; GO:0045088; GO:0045121; GO:0050727; GO:0051291; GO:0060544; GO:0060546; GO:0070424; GO:1990001; GO:2000116 0 0 0 PF00653;PF00619; Q14590 CHOYP_ZNF98.1.1 m.17909 sp ZN235_HUMAN 38.312 308 177 8 27 330 319 617 5.69E-59 205 ZN235_HUMAN reviewed Zinc finger protein 235 (Zinc finger protein 270) (Zinc finger protein 93 homolog) (Zfp-93) (Zinc finger protein HZF6) ZNF235 ZFP93 ZNF270 Homo sapiens (Human) 738 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q4PM12 CHOYP_BRAFLDRAFT_279545.1.1 m.35 sp RL36_IXOSC 56.18 89 37 1 1 89 1 87 5.69E-27 98.2 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q60989 CHOYP_XIAP.3.7 m.16591 sp XIAP_MOUSE 32.768 177 112 5 48 222 158 329 5.69E-17 82.4 XIAP_MOUSE reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) 496 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; neuron apoptotic process [GO:0051402]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005737; GO:0008270; GO:0016055; GO:0016874; GO:0031398; GO:0043027; GO:0043066; GO:0043154; GO:0051402; GO:0061630; GO:0090263; GO:1902530; GO:1990001 0 0 0 PF00653; Q6H236 CHOYP_contig_051198 m.61094 sp PEG3_BOVIN 38.564 376 177 22 226 547 1118 1493 5.69E-14 79.3 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6NXT6 CHOYP_AGAP_AGAP002775.1.1 m.957 sp TAPT1_HUMAN 53.763 93 42 1 31 123 66 157 5.69E-27 107 TAPT1_HUMAN reviewed Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) TAPT1 CMVFR Homo sapiens (Human) 567 cartilage development [GO:0051216]; cell projection organization [GO:0030030]; embryonic skeletal system development [GO:0048706]; in utero embryonic development [GO:0001701]; neural crest cell development [GO:0014032]; ossification [GO:0001503]; positive regulation of bone development [GO:1903012]; positive regulation of cartilage development [GO:0061036]; positive regulation of cilium assembly [GO:0045724]; post-embryonic development [GO:0009791] GO:0001503; GO:0001701; GO:0005737; GO:0005813; GO:0009791; GO:0014032; GO:0016021; GO:0016520; GO:0030030; GO:0036064; GO:0045724; GO:0048706; GO:0051216; GO:0061036; GO:1903012 0 0 0 PF05346; Q6Q899 CHOYP_IFIH1.12.14 m.63742 sp DDX58_MOUSE 26.957 920 588 30 133 1004 14 897 5.69E-79 280 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q803M3 CHOYP_TEX10.2.3 m.28279 sp TEX10_DANRE 34.573 457 251 13 5 425 4 448 5.69E-68 238 TEX10_DANRE reviewed Testis-expressed sequence 10 protein homolog tex10 zgc:55523 Danio rerio (Zebrafish) (Brachydanio rerio) 933 maturation of LSU-rRNA [GO:0000470]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000470; GO:0003682; GO:0005730; GO:0016021; GO:0030174; GO:0030687; GO:0031965; GO:0071339; GO:0097344 0 0 0 PF12333; Q95LU3 CHOYP_FGL1.5.6 m.52535 sp FBCD1_MACFA 34.347 329 177 8 14 303 98 426 5.69E-52 179 FBCD1_MACFA reviewed Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 431 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q96MM6 CHOYP_HS12B.13.14 m.63427 sp HS12B_HUMAN 32.613 509 260 15 14 467 54 534 5.69E-69 235 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BVK2 CHOYP_ALG8.1.2 m.7324 sp ALG8_HUMAN 57.027 370 150 3 1 366 153 517 5.69E-144 421 ALG8_HUMAN reviewed "Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)" ALG8 HUSSY-02 Homo sapiens (Human) 526 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide-lipid intermediate biosynthetic process [GO:0006490]; protein N-linked glycosylation [GO:0006487] GO:0000033; GO:0004583; GO:0005789; GO:0006487; GO:0006488; GO:0006490; GO:0016021; GO:0042281 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03155; Q9D6K9 CHOYP_LOC100674871.1.1 m.44942 sp CERS5_MOUSE 46.544 217 111 1 2 218 138 349 5.69E-65 210 CERS5_MOUSE reviewed Ceramide synthase 5 (CerS5) (EC 2.3.1.24) (LAG1 longevity assurance homolog 5) (Translocating chain-associating membrane protein homolog 4) (TRAM homolog 4) Cers5 Lass5 Trh4 Mus musculus (Mouse) 414 ceramide biosynthetic process [GO:0046513]; sphingolipid biosynthetic process [GO:0030148] GO:0003677; GO:0005783; GO:0005789; GO:0016021; GO:0030148; GO:0031965; GO:0046513; GO:0050291 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00046;PF03798; Q9ESN6 CHOYP_BRAFLDRAFT_88219.2.5 m.39787 sp TRIM2_MOUSE 22.713 317 207 11 268 570 452 744 5.69E-10 65.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ET67 CHOYP_PEX12.1.1 m.31340 sp PEX12_CRILO 49.025 359 166 6 1 342 1 359 5.69E-111 330 PEX12_CRILO reviewed Peroxisome assembly protein 12 (Peroxin-12) PEX12 Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) 359 peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558] GO:0005779; GO:0007031; GO:0008270; GO:0016558 0 0 0 PF04757; Q9ULI1 CHOYP_LOC100374526.1.1 m.37007 sp NWD2_HUMAN 28.215 521 327 16 147 629 21 532 5.69E-51 194 NWD2_HUMAN reviewed NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 0 0 0 0 0 PF13271; Q9Z2H2 CHOYP_DWIL_GK10200.1.1 m.12018 sp RGS6_MOUSE 39.301 458 238 11 4 436 8 450 5.69E-95 302 RGS6_MOUSE reviewed Regulator of G-protein signaling 6 (RGS6) Rgs6 Mus musculus (Mouse) 472 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547] GO:0004871; GO:0005096; GO:0005634; GO:0005737; GO:0005829; GO:0005834; GO:0005886; GO:0007186; GO:0009968; GO:0019898; GO:0035556; GO:0043547 0 0 cd00068; PF00610;PF00631;PF00615; F7H9X2 CHOYP_TRIM2.36.59 m.38810 sp TRIM2_CALJA 26.054 261 169 8 32 276 492 744 5.70E-11 66.2 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O35593 CHOYP_EF1A2.3.3 m.57361 sp PSDE_MOUSE 97.283 184 4 1 1 184 1 183 5.70E-129 367 PSDE_MOUSE reviewed 26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory subunit RPN11) (MAD1) Psmd14 Pad1 Mus musculus (Mouse) 310 double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; protein K63-linked deubiquitination [GO:0070536]; regulation of proteasomal protein catabolic process [GO:0061136]; response to ethanol [GO:0045471] GO:0000502; GO:0000724; GO:0004175; GO:0005634; GO:0006303; GO:0008237; GO:0008541; GO:0022624; GO:0031597; GO:0045471; GO:0046872; GO:0061133; GO:0061136; GO:0070062; GO:0070536; GO:0070628 0 0 0 PF01398;PF13012; O42387 CHOYP_RPS24.1.8 m.571 sp RS24_TAKRU 80.342 117 23 0 37 153 6 122 5.70E-65 199 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O88992 CHOYP_C1QL2.19.32 m.29743 sp C1QRF_MOUSE 31.783 129 80 4 484 607 131 256 5.70E-10 63.9 C1QRF_MOUSE reviewed C1q-related factor (C1q and tumor necrosis factor-related protein 14) (C1q/TNF-related protein 14) (CTRP14) (Complement component 1 Q subcomponent-like 1) C1ql1 C1qrf Crf Ctrp14 Mus musculus (Mouse) 258 maintenance of synapse structure [GO:0099558]; motor learning [GO:0061743]; neuron remodeling [GO:0016322] GO:0005102; GO:0005581; GO:0005737; GO:0016322; GO:0043083; GO:0044301; GO:0061743; GO:0098793; GO:0099558 0 0 0 PF00386;PF01391; P15206 CHOYP_CCNB2.1.1 m.16388 sp CCNB_MARGL 32.432 259 171 1 111 365 112 370 5.70E-51 178 CCNB_MARGL reviewed G2/mitotic-specific cyclin-B 0 Marthasterias glacialis (Spiny starfish) 388 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134; P21941 CHOYP_MATN1.4.5 m.60311 sp MATN1_HUMAN 29.083 447 273 13 44 481 41 452 5.70E-47 176 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P51521 CHOYP_ISCW_ISCW013547.1.1 m.12719 sp OVO_DROME 68.966 145 45 0 588 732 1188 1332 5.70E-67 244 OVO_DROME reviewed Protein ovo (Protein shaven baby) ovo Svb CG6824 Drosophila melanogaster (Fruit fly) 1351 "adult feeding behavior [GO:0008343]; cuticle development [GO:0042335]; cuticle pattern formation [GO:0035017]; cuticle pigmentation [GO:0048067]; cytoskeleton organization [GO:0007010]; epidermal cell differentiation [GO:0009913]; female germ-line sex determination [GO:0019099]; germ-line sex determination [GO:0018992]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; non-sensory hair organization [GO:0035316]; oogenesis [GO:0048477]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transposon integration [GO:0070896]; regulation of cell shape [GO:0008360]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0000981; GO:0003677; GO:0005634; GO:0005737; GO:0006355; GO:0006366; GO:0007010; GO:0008343; GO:0008360; GO:0009913; GO:0016348; GO:0018992; GO:0019099; GO:0035017; GO:0035316; GO:0042335; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0046872; GO:0048067; GO:0048477; GO:0070896 0 0 0 0 P54318 CHOYP_LIPR1.3.3 m.13374 sp LIPR2_RAT 41.42 338 183 7 54 380 5 338 5.70E-78 251 LIPR2_RAT reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) (Secretory glycoprotein GP-3) Pnliprp2 Plrp2 Rattus norvegicus (Rat) 468 galactolipid catabolic process [GO:0019376]; phospholipid catabolic process [GO:0009395]; post-embryonic development [GO:0009791]; response to food [GO:0032094]; response to glucocorticoid [GO:0051384]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0009395; GO:0009791; GO:0016298; GO:0019376; GO:0032094; GO:0033993; GO:0042589; GO:0043434; GO:0047372; GO:0047714; GO:0051384 0 0 0 PF00151;PF01477; P59105 CHOYP_LOC100366294.1.1 m.33363 sp SLEB_OCEIH 32.258 155 77 7 685 839 148 274 5.70E-08 58.5 SLEB_OCEIH reviewed Spore cortex-lytic enzyme (SCLE) sleB OB1806 Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831) 276 cell wall organization [GO:0071555]; spore germination [GO:0009847]; sporulation resulting in formation of a cellular spore [GO:0030435] GO:0009847; GO:0016787; GO:0030435; GO:0071555 0 0 0 PF07486;PF01471; Q00959 CHOYP_LOC100533244.3.3 m.61615 sp NMDE1_RAT 40.223 179 104 2 1 177 689 866 5.70E-34 135 NMDE1_RAT reviewed "Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)" Grin2a Rattus norvegicus (Rat) 1464 action potential [GO:0001508]; cellular response to amino acid stimulus [GO:0071230]; cellular response to dsRNA [GO:0071359]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lipid [GO:0071396]; cellular response to magnesium ion [GO:0071286]; cellular response to manganese ion [GO:0071287]; cellular response to zinc ion [GO:0071294]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; excitatory postsynaptic potential [GO:0060079]; hippocampus development [GO:0021766]; ionotropic glutamate receptor signaling pathway [GO:0035235]; memory [GO:0007613]; positive regulation of cell death [GO:0010942]; positive regulation of excitatory postsynaptic potential [GO:2000463]; protein tetramerization [GO:0051262]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; response to amine [GO:0014075]; response to ammonium ion [GO:0060359]; response to calcium ion [GO:0051592]; response to carbohydrate [GO:0009743]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; response to light stimulus [GO:0009416]; response to manganese ion [GO:0010042]; response to methylmercury [GO:0051597]; response to organic cyclic compound [GO:0014070]; response to other organism [GO:0051707]; rhythmic process [GO:0048511]; spinal cord development [GO:0021510] GO:0001508; GO:0004970; GO:0004972; GO:0005102; GO:0005234; GO:0007268; GO:0007613; GO:0008270; GO:0009416; GO:0009743; GO:0010042; GO:0010942; GO:0014069; GO:0014070; GO:0014075; GO:0016595; GO:0017146; GO:0019901; GO:0021510; GO:0021766; GO:0021987; GO:0022843; GO:0030054; GO:0032403; GO:0035235; GO:0035254; GO:0042165; GO:0042220; GO:0042493; GO:0042734; GO:0043005; GO:0043195; GO:0043197; GO:0045202; GO:0045211; GO:0045471; GO:0046982; GO:0046983; GO:0048169; GO:0048511; GO:0050839; GO:0051117; GO:0051262; GO:0051592; GO:0051597; GO:0051707; GO:0060079; GO:0060359; GO:0060992; GO:0071230; GO:0071286; GO:0071287; GO:0071294; GO:0071359; GO:0071363; GO:0071396; GO:0097110; GO:2000463 0 0 0 PF01094;PF00060;PF10613;PF10565; Q09624 CHOYP_LOC100368459.1.1 m.34824 sp PKD1_CAEEL 21.702 235 155 6 1 212 2948 3176 5.70E-08 60.5 PKD1_CAEEL reviewed Location of vulva defective 1 (Polycystic kidney disease 1 protein homolog) (Polycystin-1) lov-1 pkd-1 ZK945.9/ZK945.10 Caenorhabditis elegans 3284 detection of mechanical stimulus [GO:0050982]; male mating behavior [GO:0060179]; mating behavior [GO:0007617]; response to hermaphrodite contact [GO:0034606]; vulval location [GO:0034608] GO:0005262; GO:0005929; GO:0007617; GO:0016020; GO:0016021; GO:0019904; GO:0031513; GO:0034606; GO:0034608; GO:0043025; GO:0050982; GO:0060179 0 0 0 PF08016;PF01477; Q0E908 CHOYP_BRAFLDRAFT_69505.2.4 m.27770 sp HIL_DROME 25.207 242 159 8 5 233 546 778 5.70E-07 57.4 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q149M9 CHOYP_LOC100369007.1.1 m.11062 sp NWD1_HUMAN 28.076 837 485 19 53 879 18 747 5.70E-85 303 NWD1_HUMAN reviewed NACHT domain- and WD repeat-containing protein 1 NWD1 Homo sapiens (Human) 1564 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; Q28262 CHOYP_PLA2G7.1.1 m.10707 sp PAFA_CANLF 39.055 402 212 9 46 446 57 426 5.70E-93 291 PAFA_CANLF reviewed Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase) PLA2G7 Canis lupus familiaris (Dog) (Canis familiaris) 444 lipid catabolic process [GO:0016042] GO:0003847; GO:0005615; GO:0016042 0 0 0 PF03403; Q4QY64 CHOYP_ATAD5.1.1 m.6517 sp ATAD5_MOUSE 29.468 940 480 33 698 1533 604 1464 5.70E-75 281 ATAD5_MOUSE reviewed ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) Atad5 Frag1 Mus musculus (Mouse) 1826 cellular response to DNA damage stimulus [GO:0006974]; immunoglobulin production [GO:0002377]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; regulation of mitotic cell cycle phase transition [GO:1901990] GO:0002377; GO:0005524; GO:0005634; GO:0006974; GO:0030890; GO:0048304; GO:1901990 0 0 0 PF00004; Q4UMH6 CHOYP_TVAG_117920.1.1 m.65694 sp Y381_RICFE 21.598 676 393 23 1148 1807 618 1172 5.70E-12 75.1 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q54RA4 CHOYP_PMAA_001770.1.1 m.11519 sp Y3291_DICDI 29.904 311 175 13 10 289 12 310 5.70E-23 101 Y3291_DICDI reviewed Probable iron/ascorbate oxidoreductase DDB_G0283291 (EC 1.14.-.-) DDB_G0283291 Dictyostelium discoideum (Slime mold) 363 0 GO:0005506; GO:0051213 0 0 0 PF03171;PF14226; Q5SPB6 CHOYP_CHAC1.1.3 m.1492 sp CHAC1_DANRE 43.979 191 96 5 15 202 13 195 5.70E-48 159 CHAC1_DANRE reviewed Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 2.3.2.-) (Cation transport regulator-like protein 1) chac1 Danio rerio (Zebrafish) (Brachydanio rerio) 196 apoptotic process [GO:0006915]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein processing [GO:0010955]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; response to unfolded protein [GO:0006986] GO:0005112; GO:0005802; GO:0005829; GO:0006915; GO:0006986; GO:0007219; GO:0010955; GO:0016746; GO:0022008; GO:0045746 0 0 cd06661; PF04752; Q8BZ20 CHOYP_LOC100089554.1.1 m.18597 sp PAR12_MOUSE 28.75 160 100 6 189 337 75 231 5.70E-09 62 PAR12_MOUSE reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) 711 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q92193 CHOYP_ACT.6.27 m.15623 sp ACT_CRAVI 98.942 189 2 0 3 191 1 189 5.70E-139 393 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9JHX4 CHOYP_CASP10.1.7 m.14427 sp CASP8_RAT 32.675 557 284 14 8 552 2 479 5.70E-77 254 CASP8_RAT reviewed Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] Casp8 Rattus norvegicus (Rat) 482 activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; cellular response to organic cyclic compound [GO:0071407]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage differentiation [GO:0045651]; protein heterooligomerization [GO:0051291]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to cold [GO:0009409]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; TRAIL-activated apoptotic signaling pathway [GO:0036462] GO:0004197; GO:0005123; GO:0005164; GO:0005654; GO:0005739; GO:0005815; GO:0005829; GO:0006508; GO:0006915; GO:0008625; GO:0009409; GO:0030225; GO:0031264; GO:0031265; GO:0032025; GO:0032355; GO:0032403; GO:0032496; GO:0034612; GO:0035877; GO:0036462; GO:0042981; GO:0043005; GO:0043123; GO:0043124; GO:0043234; GO:0044297; GO:0045121; GO:0045471; GO:0045651; GO:0046677; GO:0051291; GO:0051603; GO:0071260; GO:0071407; GO:0097153; GO:0097194; GO:0097199; GO:0097202; GO:0097342 0 0 0 PF01335; Q9NWT6 CHOYP_HIF1N.1.1 m.53726 sp HIF1N_HUMAN 57.862 318 131 2 20 334 32 349 5.70E-137 395 HIF1N_HUMAN reviewed Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase) HIF1AN FIH1 Homo sapiens (Human) 349 "negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; oxidation-reduction process [GO:0055114]; peptidyl-asparagine hydroxylation [GO:0042265]; peptidyl-aspartic acid hydroxylation [GO:0042264]; peptidyl-histidine hydroxylation [GO:0036138]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription, DNA-templated [GO:0006351]" GO:0005112; GO:0005506; GO:0005654; GO:0005737; GO:0005829; GO:0006351; GO:0008270; GO:0016706; GO:0019826; GO:0031406; GO:0036138; GO:0036139; GO:0036140; GO:0042264; GO:0042265; GO:0042803; GO:0045663; GO:0045746; GO:0048037; GO:0048471; GO:0051059; GO:0055114; GO:0061418; GO:0061428; GO:0071532; GO:2001214 0 0 0 0 Q9R0M0 CHOYP_FTRAC_0410.1.1 m.35658 sp CELR2_MOUSE 27.737 411 256 17 362 747 462 856 5.70E-17 90.5 CELR2_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Flamingo homolog) Celsr2 Mus musculus (Mouse) 2920 "cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0042384]; cilium movement [GO:0003341]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of transcription, DNA-templated [GO:0006355]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]" GO:0001764; GO:0003341; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0016021; GO:0016055; GO:0021591; GO:0021999; GO:0032880; GO:0033326; GO:0042384 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9Y6R7 CHOYP_BRAFLDRAFT_66204.1.3 m.2589 sp FCGBP_HUMAN 24.586 423 291 11 19 436 28 427 5.70E-19 95.1 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; D3ZAT9 CHOYP_LOC100158373.1.1 m.45529 sp FAXC_RAT 40.161 249 132 6 34 269 90 334 5.71E-52 178 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; E9Q555 CHOYP_BRAFLDRAFT_108419.3.3 m.54321 sp RN213_MOUSE 25.494 506 340 14 5 497 3305 3786 5.71E-41 161 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O22161 CHOYP_BRAFLDRAFT_128636.1.1 m.61833 sp ADLO1_ARATH 30.769 104 71 1 312 415 434 536 5.71E-06 53.5 ADLO1_ARATH reviewed Protein ARABIDILLO 1 (F-box only protein 5) FBX5 At2g44900 T13E15.9 Arabidopsis thaliana (Mouse-ear cress) 930 lateral root development [GO:0048527] GO:0005634; GO:0005737; GO:0048527 0 0 0 PF00514; O70244 CHOYP_LOC100223474.1.1 m.25227 sp CUBN_RAT 38.346 133 73 5 33 160 3152 3280 5.71E-18 85.9 CUBN_RAT reviewed Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) 3623 cholesterol metabolic process [GO:0008203]; cobalamin transport [GO:0015889]; hemoglobin import [GO:0020028]; in utero embryonic development [GO:0001701]; protein homotrimerization [GO:0070207]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to nutrient [GO:0007584]; vitamin metabolic process [GO:0006766] GO:0001701; GO:0004872; GO:0005509; GO:0005765; GO:0005905; GO:0006766; GO:0006898; GO:0007584; GO:0008203; GO:0010008; GO:0015031; GO:0015235; GO:0015889; GO:0016020; GO:0020028; GO:0030135; GO:0030492; GO:0030666; GO:0031419; GO:0031526; GO:0042802; GO:0043202; GO:0043234; GO:0070207 0 0 0 PF00431;PF00008;PF12947;PF07645; P08684 CHOYP_CP3AL.1.1 m.47224 sp CP3A4_HUMAN 38.211 123 59 4 2 123 225 331 5.71E-17 79.3 CP3A4_HUMAN reviewed "Cytochrome P450 3A4 (EC 1.14.13.-) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.13.157) (Albendazole monooxygenase) (EC 1.14.13.32) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (EC 1.14.14.1) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.13.67) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.13.97)" CYP3A4 CYP3A3 Homo sapiens (Human) 503 alkaloid catabolic process [GO:0009822]; androgen metabolic process [GO:0008209]; drug catabolic process [GO:0042737]; drug metabolic process [GO:0017144]; exogenous drug catabolic process [GO:0042738]; heterocycle metabolic process [GO:0046483]; lipid metabolic process [GO:0006629]; monoterpenoid metabolic process [GO:0016098]; oxidation-reduction process [GO:0055114]; oxidative demethylation [GO:0070989]; steroid catabolic process [GO:0006706]; steroid metabolic process [GO:0008202]; vitamin D metabolic process [GO:0042359]; xenobiotic metabolic process [GO:0006805] GO:0004497; GO:0005496; GO:0005506; GO:0005737; GO:0005789; GO:0006629; GO:0006706; GO:0006805; GO:0008202; GO:0008209; GO:0008395; GO:0009822; GO:0016021; GO:0016098; GO:0016491; GO:0017144; GO:0019825; GO:0019899; GO:0020037; GO:0030343; GO:0031090; GO:0033780; GO:0034875; GO:0042359; GO:0042737; GO:0042738; GO:0043231; GO:0046483; GO:0047638; GO:0050591; GO:0050649; GO:0055114; GO:0070330; GO:0070576; GO:0070989 0 0 0 PF00067; P10982 CHOYP_ACT.15.27 m.41971 sp ACT1_ABSGL 78.788 132 27 1 1 131 1 132 5.71E-76 224 ACT1_ABSGL reviewed Actin-1 (Fragment) ACT1 Absidia glauca (Pin mould) 140 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P12001 CHOYP_LOC100875987.2.2 m.63382 sp RL18_RAT 73.714 175 46 0 18 192 1 175 5.71E-95 277 RL18_RAT reviewed 60S ribosomal protein L18 Rpl18 Rattus norvegicus (Rat) 188 liver regeneration [GO:0097421]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0097421 0 0 0 PF17135; P15880 CHOYP_RS2.6.10 m.37378 sp RS2_HUMAN 90.769 195 18 0 1 195 61 255 5.71E-129 369 RS2_HUMAN reviewed 40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) RPS2 RPS4 Homo sapiens (Human) 293 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of transferase activity [GO:0051347]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003729; GO:0003735; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005913; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0017134; GO:0019083; GO:0019899; GO:0022627; GO:0044822; GO:0051347; GO:0070062; GO:0098641 0 0 0 PF00333;PF03719; P37064 CHOYP_LOC100376857.7.7 m.64339 sp ASO_CUCPM 28.934 591 297 26 122 675 23 527 5.71E-46 175 ASO_CUCPM reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) 0 Cucurbita pepo var. melopepo (Zucchini) 552 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P55265 CHOYP_ADAR.3.3 m.60419 sp DSRAD_HUMAN 47.407 270 128 7 4 260 955 1223 5.71E-69 233 DSRAD_HUMAN reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) 1226 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337] GO:0001649; GO:0001701; GO:0002244; GO:0002566; GO:0003677; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006397; GO:0006606; GO:0006611; GO:0009615; GO:0016020; GO:0016553; GO:0030218; GO:0031054; GO:0035280; GO:0035455; GO:0043066; GO:0044387; GO:0044530; GO:0044822; GO:0045070; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060216; GO:0060337; GO:0060339; GO:0061484; GO:0098586; GO:1900369 0 0 0 PF02137;PF00035;PF02295; Q1MSJ5 CHOYP_CSPP1.9.14 m.48289 sp CSPP1_HUMAN 34.371 707 360 23 707 1339 549 1225 5.71E-51 201 CSPP1_HUMAN reviewed Centrosome and spindle pole-associated protein 1 CSPP1 CSPP Homo sapiens (Human) 1256 positive regulation of cell division [GO:0051781]; positive regulation of cytokinesis [GO:0032467] GO:0000922; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005874; GO:0032467; GO:0051781 0 0 0 0 Q24K15 CHOYP_BRAFLDRAFT_59661.6.6 m.60648 sp ANGP4_BOVIN 41.228 228 124 6 82 306 275 495 5.71E-59 199 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q5G271 CHOYP_TRIADDRAFT_53242.3.3 m.47405 sp NETR_PANTR 48.571 105 46 4 293 394 500 599 5.71E-18 89.7 NETR_PANTR reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Pan troglodytes (Chimpanzee) 875 exocytosis [GO:0006887]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006887; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195 0 0 cd00190; PF00051;PF00530;PF00089; Q5U538 CHOYP_LOC100636450.2.2 m.12943 sp HARB1_XENLA 25.362 138 94 5 123 255 93 226 5.71E-06 51.2 HARB1_XENLA reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 Xenopus laevis (African clawed frog) 347 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6QI06 CHOYP_RICTOR.1.1 m.20441 sp RICTR_MOUSE 46.617 133 70 1 1 132 14 146 5.71E-30 117 RICTR_MOUSE reviewed Rapamycin-insensitive companion of mTOR (AVO3 homolog) (mAVO3) (Protein pianissimo) Rictor Kiaa1999 Mus musculus (Mouse) 1708 actin cytoskeleton reorganization [GO:0031532]; embryo development [GO:0009790]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of TOR signaling [GO:0032008]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of establishment of cell polarity [GO:2000114]; regulation of gene expression [GO:0010468]; regulation of GTPase activity [GO:0043087]; regulation of inflammatory response [GO:0050727]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of protein kinase B signaling [GO:0051896]; regulation of protein phosphorylation [GO:0001932]; TOR signaling [GO:0031929] GO:0001932; GO:0001938; GO:0008047; GO:0009790; GO:0010468; GO:0018105; GO:0019901; GO:0030838; GO:0030950; GO:0031532; GO:0031929; GO:0031932; GO:0032008; GO:0032956; GO:0033135; GO:0043022; GO:0043087; GO:0050727; GO:0050731; GO:0051896; GO:0051897; GO:2000114 0 0 0 PF14663;PF14666;PF14664;PF14665;PF14668; Q7RTY7 CHOYP_LOC100366428.1.1 m.3739 sp OVCH1_HUMAN 30.169 474 296 11 465 931 366 811 5.71E-62 232 OVCH1_HUMAN reviewed Ovochymase-1 (EC 3.4.21.-) OVCH1 Homo sapiens (Human) 1134 0 GO:0004252; GO:0005576; GO:0046872 0 0 cd00190; PF00431;PF00089; Q8TBZ9 CHOYP_LOC579291.1.1 m.3101 sp CG062_HUMAN 32.759 232 147 3 17 244 27 253 5.71E-40 141 CG062_HUMAN reviewed Uncharacterized protein C7orf62 C7orf62 Homo sapiens (Human) 253 0 0 0 0 0 0 Q964T1 CHOYP_BRAFLDRAFT_117251.1.1 m.6685 sp CP4CU_BLAGE 30.37 135 87 4 49 180 31 161 5.71E-09 58.2 CP4CU_BLAGE reviewed Cytochrome P450 4c21 (EC 1.14.14.1) (CYPIVC21) CYP4C21 Blattella germanica (German cockroach) (Blatta germanica) 501 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q9H8L6 CHOYP_LOC100698726.7.8 m.30454 sp MMRN2_HUMAN 29.457 129 82 4 133 261 825 944 5.71E-07 53.9 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; Q9VCA8 CHOYP_LOC100637968.2.12 m.14186 sp ANKHM_DROME 34.483 406 239 13 1 384 625 1025 5.71E-48 178 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; G5EFX6 CHOYP_NOTCH.4.6 m.47780 sp SLIT1_CAEEL 32.707 266 137 15 186 418 861 1117 5.72E-19 95.1 SLIT1_CAEEL reviewed Slit homolog 1 protein (Slt-1) slt-1 F40E10.4 Caenorhabditis elegans 1410 dorsal/ventral axon guidance [GO:0033563]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron migration [GO:0001764]; Roundabout signaling pathway [GO:0035385] GO:0001764; GO:0005102; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0008201; GO:0033563; GO:0035385; GO:0048495; GO:0048843 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01462; O15553 CHOYP_TRIM29.1.1 m.32439 sp MEFV_HUMAN 43.548 62 33 2 78 138 373 433 5.72E-06 50.1 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; O94760 CHOYP_ABCB6.2.3 m.11344 sp DDAH1_HUMAN 37.091 275 160 6 7 275 14 281 5.72E-52 175 DDAH1_HUMAN reviewed "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)" DDAH1 DDAH Homo sapiens (Human) 285 arginine catabolic process [GO:0006527]; citrulline metabolic process [GO:0000052]; nitric oxide mediated signal transduction [GO:0007263]; positive regulation of angiogenesis [GO:0045766]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of systemic arterial blood pressure [GO:0003073] GO:0000052; GO:0003073; GO:0003824; GO:0005739; GO:0005829; GO:0006527; GO:0007263; GO:0016403; GO:0016597; GO:0045429; GO:0045766; GO:0046872; GO:0050999; GO:0070062 0 0 0 0 P02693 CHOYP_LOC100566943.2.2 m.38725 sp FABPI_RAT 37.778 135 72 3 8 136 3 131 5.72E-14 67 FABPI_RAT reviewed "Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)" Fabp2 Fabpi Rattus norvegicus (Rat) 132 fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; long-chain fatty acid transport [GO:0015909] GO:0005324; GO:0005504; GO:0005737; GO:0005886; GO:0005902; GO:0006631; GO:0015908; GO:0015909; GO:0045179; GO:0050892 0 0 0 PF00061; P0CB42 CHOYP_ALKB1.1.1 m.11559 sp ALKB1_MOUSE 37.19 363 192 9 10 355 15 358 5.72E-72 232 ALKB1_MOUSE reviewed DNA demethylase ALKBH1 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 1) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA 6mA demethylase) (DNA N6-methyl adenine demethylase) (EC 1.14.11.-) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1) (EC 1.14.11.33) Alkbh1 Abh Alkbh Mus musculus (Mouse) 389 cell differentiation [GO:0030154]; developmental growth [GO:0048589]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; in utero embryonic development [GO:0001701]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oxidative demethylation [GO:0070989]; placenta development [GO:0001890]; regulation of gene expression [GO:0010468]; RNA repair [GO:0042245] GO:0001701; GO:0001764; GO:0001890; GO:0003906; GO:0005719; GO:0005739; GO:0006281; GO:0006307; GO:0008198; GO:0010468; GO:0030154; GO:0031175; GO:0042056; GO:0042245; GO:0043524; GO:0048589; GO:0070579; GO:0070989; GO:0080111 0 0 0 PF13532; P21613 CHOYP_KINH.4.9 m.33827 sp KINH_DORPE 75.369 203 48 2 85 287 725 925 5.72E-90 290 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P48509 CHOYP_contig_032705 m.37358 sp CD151_HUMAN 24.862 181 117 4 16 196 24 185 5.72E-07 53.1 CD151_HUMAN reviewed CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151) CD151 TSPAN24 Homo sapiens (Human) 253 cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; hemidesmosome assembly [GO:0031581]; T cell proliferation [GO:0042098] GO:0005178; GO:0005604; GO:0005829; GO:0005886; GO:0005887; GO:0005925; GO:0007155; GO:0007166; GO:0016020; GO:0016477; GO:0031581; GO:0042098 0 0 0 PF00335; P62914 CHOYP_RL11.2.7 m.12991 sp RL11_RAT 86.628 172 23 0 31 202 7 178 5.72E-110 315 RL11_RAT reviewed 60S ribosomal protein L11 Rpl11 Rattus norvegicus (Rat) 178 negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; protein localization to nucleus [GO:0034504]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0019843; GO:0022625; GO:0022626; GO:0034504; GO:0042975; GO:0043433 0 0 0 PF00281;PF00673; P91924 CHOYP_CPIPJ_CPIJ004239.1.1 m.42757 sp ARF_DUGJA 89.72 107 11 0 10 116 76 182 5.72E-69 209 ARF_DUGJA reviewed ADP-ribosylation factor 0 Dugesia japonica (Planarian) 183 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005794; GO:0007264; GO:0015031; GO:0016192 0 0 0 PF00025; Q32LJ3 CHOYP_LOC100373454.1.1 m.59681 sp CX065_BOVIN 36.134 119 67 4 1 116 1 113 5.72E-12 63.5 CX065_BOVIN reviewed Uncharacterized protein CXorf65 homolog 0 Bos taurus (Bovine) 174 0 0 0 0 0 0 Q5UQP2 CHOYP_LOC582782.4.4 m.62807 sp YL446_MIMIV 28.922 204 133 3 78 279 45 238 5.72E-18 89 YL446_MIMIV reviewed Uncharacterized protein L446 (EC 3.1.1.-) MIMI_L446 Acanthamoeba polyphaga mimivirus (APMV) 332 lipid catabolic process [GO:0016042] GO:0016021; GO:0016042; GO:0016787 0 0 0 PF01734; Q5ZJH7 CHOYP_LOC100372380.1.1 m.51206 sp CNPD1_CHICK 37.979 287 168 3 8 288 6 288 5.72E-63 214 CNPD1_CHICK reviewed Protein CNPPD1 CNPPD1 RCJMB04_3a20 Gallus gallus (Chicken) 439 regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079] GO:0000079; GO:0016021 0 0 0 PF08613; Q6AYB3 CHOYP_ISY1.1.1 m.53545 sp ISY1_RAT 66.202 287 92 3 1 286 1 283 5.72E-126 363 ISY1_RAT reviewed Pre-mRNA-splicing factor ISY1 homolog Isy1 Rattus norvegicus (Rat) 284 generation of catalytic spliceosome for second transesterification step [GO:0000350]; mRNA 3'-splice site recognition [GO:0000389] GO:0000350; GO:0000389; GO:0000974; GO:0071012; GO:0071013; GO:0071014; GO:0071020 0 0 0 PF06246; Q6H236 CHOYP_contig_042083 m.48342 sp PEG3_BOVIN 38.83 376 176 22 127 448 1118 1493 5.72E-12 73.9 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6PGS5 CHOYP_BRAFLDRAFT_92202.1.2 m.28707 sp TM56B_XENLA 42.424 231 132 1 20 249 15 245 5.72E-64 204 TM56B_XENLA reviewed Transmembrane protein 56-B tmem56-b Xenopus laevis (African clawed frog) 262 0 GO:0016021 0 0 0 PF03798; Q90YG6 CHOYP_T2AG.1.1 m.6205 sp T2AG_ONCMY 81.373 102 19 0 1 102 1 102 5.72E-58 176 T2AG_ONCMY reviewed Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) gtf2a2 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 108 "regulation of transcription, DNA-templated [GO:0006355]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0005672; GO:0006355; GO:0006367 0 0 cd10014;cd10145; PF02751;PF02268; Q9DG68 CHOYP_LOC660560.2.4 m.40913 sp RLA0_RANSY 71.273 275 79 0 1 275 1 275 5.72E-147 419 RLA0_RANSY reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) RPLP0 Rana sylvatica (Wood frog) 315 ribosome biogenesis [GO:0042254] GO:0005840; GO:0042254 0 0 0 PF00466; Q9H0J4 CHOYP_LOC100378873.1.3 m.9863 sp QRIC2_HUMAN 36.387 393 181 9 354 681 1227 1615 5.72E-66 243 QRIC2_HUMAN reviewed Glutamine-rich protein 2 QRICH2 Homo sapiens (Human) 1663 0 0 0 0 0 PF16043; Q9UGM3 CHOYP_BRAFLDRAFT_68917.1.3 m.16606 sp DMBT1_HUMAN 33.768 613 328 13 464 1020 371 961 5.72E-79 293 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9Z2J0 CHOYP_BRAFLDRAFT_118178.1.1 m.13101 sp S23A1_MOUSE 45 120 57 4 1 117 475 588 5.72E-25 102 S23A1_MOUSE reviewed Solute carrier family 23 member 1 (Na(+)/L-ascorbic acid transporter 1) (Sodium-dependent vitamin C transporter 1) (Yolk sac permease-like molecule 3) Slc23a1 Svct1 Yspl3 Mus musculus (Mouse) 605 brain development [GO:0007420]; dehydroascorbic acid transport [GO:0070837]; L-ascorbic acid transport [GO:0015882]; lung development [GO:0030324]; response to toxic substance [GO:0009636]; sodium ion transport [GO:0006814]; transepithelial L-ascorbic acid transport [GO:0070904] GO:0005737; GO:0005886; GO:0006814; GO:0007420; GO:0008520; GO:0009636; GO:0009925; GO:0015081; GO:0015229; GO:0015882; GO:0016021; GO:0016324; GO:0030324; GO:0033300; GO:0043229; GO:0070062; GO:0070837; GO:0070890; GO:0070904 0 0 0 PF00860; O14974 CHOYP_LOC100114433.3.4 m.46012 sp MYPT1_HUMAN 60.49 286 113 0 6 291 2 287 5.73E-116 386 MYPT1_HUMAN reviewed Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) 1030 cellular response to drug [GO:0035690]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; negative regulation of catalytic activity [GO:0043086]; positive regulation of myosin-light-chain-phosphatase activity [GO:0035508]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of nucleocytoplasmic transport [GO:0046822] GO:0000086; GO:0000776; GO:0004721; GO:0004857; GO:0004871; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005925; GO:0006470; GO:0007067; GO:0015629; GO:0019208; GO:0019901; GO:0030018; GO:0030155; GO:0031672; GO:0035507; GO:0035508; GO:0035690; GO:0043086; GO:0043292; GO:0045944; GO:0046822; GO:0051297; GO:0071889; GO:0072357 0 0 0 PF12796;PF15898; O95817 CHOYP_LOC100186360.2.2 m.54733 sp BAG3_HUMAN 55.882 34 15 0 7 40 21 54 5.73E-06 52.4 BAG3_HUMAN reviewed BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) 575 brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cellular response to heat [GO:1900034]; spinal cord development [GO:0021510] GO:0000774; GO:0005737; GO:0005829; GO:0005886; GO:0005913; GO:0006457; GO:0007420; GO:0008625; GO:0010664; GO:0021510; GO:0030018; GO:0043005; GO:0043066; GO:0050821; GO:0071260; GO:0097192; GO:0098641; GO:1900034 0 0 0 PF02179;PF00397; P27615 CHOYP_LOC100705846.1.1 m.56864 sp SCRB2_RAT 36.842 437 259 9 29 463 28 449 5.73E-103 319 SCRB2_RAT reviewed Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) Scarb2 Cd36l2 Limpii Rattus norvegicus (Rat) 478 protein targeting to lysosome [GO:0006622] GO:0004872; GO:0005765; GO:0005925; GO:0006622; GO:0016021; GO:0043202; GO:0070062 0 0 0 PF01130; P30975 CHOYP_LOC100744404.1.1 m.43810 sp TLR2_DROME 46.575 365 173 6 18 369 96 451 5.73E-107 327 TLR2_DROME reviewed Tachykinin-like peptides receptor 99D (Tachykinin-like receptor at 99D) (dTKR) TkR99D Takr99D CG7887 Drosophila melanogaster (Fruit fly) 519 detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of synaptic transmission [GO:0050805]; neuropeptide signaling pathway [GO:0007218]; olfactory behavior [GO:0042048]; positive regulation of sensory perception of pain [GO:1904058]; tachykinin receptor signaling pathway [GO:0007217] GO:0004995; GO:0005886; GO:0005887; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016021; GO:0042048; GO:0050805; GO:0050911; GO:1904058 0 0 0 PF00001; P31331 CHOYP_LOC100378901.2.2 m.56894 sp GLB_NASMU 28.671 143 101 1 51 192 1 143 5.73E-16 74.7 GLB_NASMU reviewed Globin (Myoglobin) 0 Nassarius mutabilis (Sea snail) (Buccinum mutabile) 147 0 GO:0005344; GO:0005506; GO:0005576; GO:0005833; GO:0019825; GO:0020037 0 0 0 PF00042; P61294 CHOYP_LOC100874837.1.1 m.56663 sp RAB6B_MOUSE 94.34 106 6 0 1 106 1 106 5.73E-70 210 RAB6B_MOUSE reviewed Ras-related protein Rab-6B Rab6b D9Bwg0185e Mus musculus (Mouse) 208 "intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; small GTPase mediated signal transduction [GO:0007264]" GO:0000139; GO:0005525; GO:0005793; GO:0005794; GO:0005829; GO:0006890; GO:0006891; GO:0007264; GO:0015031; GO:0016023; GO:0031489; GO:0042147 0 0 0 PF00071; Q13490 CHOYP_BRAFLDRAFT_117715.1.3 m.56438 sp BIRC2_HUMAN 24.314 255 157 7 418 664 391 617 5.73E-15 82 BIRC2_HUMAN reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 MIHB RNF48 Homo sapiens (Human) 618 "cell surface receptor signaling pathway [GO:0007166]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; NIK/NF-kappaB signaling [GO:0038061]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell proliferation [GO:0042127]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006921; GO:0007166; GO:0007249; GO:0008270; GO:0009898; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0033209; GO:0034121; GO:0035631; GO:0035666; GO:0038061; GO:0039535; GO:0042127; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045088; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0070266; GO:0070424; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000116; GO:2000377 0 0 0 PF00653;PF00619; Q5DU57 CHOYP_ISCW_ISCW011606.2.2 m.41757 sp SPT13_MOUSE 46.208 567 276 9 2124 2680 73 620 5.73E-159 511 SPT13_MOUSE reviewed Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) Spata13 Mus musculus (Mouse) 656 cell migration [GO:0016477]; filopodium assembly [GO:0046847]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]; regulation of Rho protein signal transduction [GO:0035023] GO:0005085; GO:0005654; GO:0005737; GO:0016477; GO:0030027; GO:0030032; GO:0030175; GO:0030334; GO:0030676; GO:0032587; GO:0035023; GO:0035556; GO:0046847 0 0 0 PF00169;PF00621;PF00018; Q5U2Q3 CHOYP_LOC100376984.1.1 m.15840 sp CK054_RAT 52.459 305 140 3 43 342 10 314 5.73E-110 326 CK054_RAT reviewed Ester hydrolase C11orf54 homolog (EC 3.1.-.-) 0 Rattus norvegicus (Rat) 315 0 GO:0005634; GO:0008270; GO:0016788; GO:0070062 0 0 0 PF08925; Q8CG09 CHOYP_MRP1.2.10 m.23573 sp MRP1_RAT 36.877 301 166 7 1 295 178 460 5.73E-53 189 MRP1_RAT reviewed Multidrug resistance-associated protein 1 (ATP-binding cassette sub-family C member 1) (Leukotriene C(4) transporter) (LTC4 transporter) Abcc1 Mrp1 Rattus norvegicus (Rat) 1532 cell chemotaxis [GO:0060326]; daunorubicin transport [GO:0043215]; drug export [GO:0046618]; drug transmembrane transport [GO:0006855]; glutathione transmembrane transport [GO:0034775]; negative regulation of neuron death [GO:1901215]; phospholipid efflux [GO:0033700]; plasma membrane long-chain fatty acid transport [GO:0015911]; positive regulation of cell migration [GO:0030335]; response to drug [GO:0042493]; response to oxidative stress [GO:0006979]; transmembrane transport [GO:0055085]; xenobiotic transport [GO:0042908] GO:0005324; GO:0005524; GO:0005737; GO:0005886; GO:0005887; GO:0006855; GO:0006979; GO:0008559; GO:0015238; GO:0015431; GO:0015562; GO:0015911; GO:0016020; GO:0016323; GO:0016491; GO:0030335; GO:0033700; GO:0034040; GO:0034634; GO:0034775; GO:0042493; GO:0042908; GO:0043215; GO:0046618; GO:0046624; GO:0055085; GO:0060326; GO:1901215 0 0 0 PF00664;PF00005; Q8K0U4 CHOYP_BRAFLDRAFT_208197.6.21 m.21765 sp HS12A_MOUSE 33.228 632 348 14 1 577 62 674 5.73E-98 315 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8VHK2 CHOYP_CSKI2.1.1 m.29327 sp CSKI1_RAT 56.637 339 143 3 1 336 1 338 5.73E-115 397 CSKI1_RAT reviewed Caskin-1 (CASK-interacting protein 1) Caskin1 Rattus norvegicus (Rat) 1430 signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0019904 0 0 0 PF12796;PF16632;PF00536;PF07653; Q9DAN9 CHOYP_LOC100375219.1.1 m.30269 sp CQ105_MOUSE 38 150 91 1 4 151 9 158 5.73E-25 99.8 CQ105_MOUSE reviewed Uncharacterized protein C17orf105 homolog 0 Mus musculus (Mouse) 164 0 0 0 0 0 PF13879; Q9H0J9 CHOYP_BRAFLDRAFT_92020.1.3 m.52306 sp PAR12_HUMAN 27.586 145 87 6 309 437 73 215 5.73E-06 52.8 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9JIA7 CHOYP_LOC100494664.1.1 m.10536 sp SPHK2_MOUSE 30.709 635 379 15 7 622 15 607 5.73E-79 265 SPHK2_MOUSE reviewed Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) Sphk2 Mus musculus (Mouse) 617 blood vessel development [GO:0001568]; brain development [GO:0007420]; cell proliferation [GO:0008283]; female pregnancy [GO:0007565]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell proliferation [GO:0008284]; sphinganine-1-phosphate biosynthetic process [GO:0006669]; sphingosine biosynthetic process [GO:0046512]; sphingosine metabolic process [GO:0006670] GO:0001568; GO:0005524; GO:0005765; GO:0005829; GO:0006669; GO:0006670; GO:0007420; GO:0007565; GO:0008283; GO:0008284; GO:0008481; GO:0016020; GO:0017050; GO:0038036; GO:0043066; GO:0046512 0 0 0 PF00781; Q9R1R2 CHOYP_BRAFLDRAFT_87294.3.6 m.39420 sp TRIM3_MOUSE 25.301 249 138 10 37 264 523 744 5.73E-10 62.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9WYX8 CHOYP_LOC100368311.1.2 m.26732 sp Y508_THEMA 29.341 167 112 3 417 583 429 589 5.73E-12 72.8 Y508_THEMA reviewed Uncharacterized protein TM_0508 TM_0508 Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) 599 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] GO:0003677; GO:0005524; GO:0006260; GO:0006281; GO:0006310; GO:0009378 0 0 0 PF16193;PF01661;PF12002;PF05496; D2GXS7 CHOYP_LOC101169131.1.2 m.6806 sp TRIM2_AILME 26.033 242 146 7 73 300 521 743 5.74E-10 63.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O55071 CHOYP_CP2C1.1.1 m.49658 sp CP2BJ_MOUSE 34.641 459 292 5 7 461 4 458 5.74E-97 303 CP2BJ_MOUSE reviewed Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19) Cyp2b19 Mus musculus (Mouse) 492 epoxygenase P450 pathway [GO:0019373] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019373; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; O75342 CHOYP_LOC583823.1.1 m.21024 sp LX12B_HUMAN 28.606 416 258 14 129 521 233 632 5.74E-38 151 LX12B_HUMAN reviewed "Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)" ALOX12B Homo sapiens (Human) 701 arachidonic acid metabolic process [GO:0019369]; ceramide biosynthetic process [GO:0046513]; establishment of skin barrier [GO:0061436]; hepoxilin biosynthetic process [GO:0051122]; linoleic acid metabolic process [GO:0043651]; lipoxygenase pathway [GO:0019372]; oxidation-reduction process [GO:0055114]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mucus secretion [GO:0070257]; protein lipidation [GO:0006497]; sphingolipid metabolic process [GO:0006665] GO:0004052; GO:0005506; GO:0005829; GO:0006497; GO:0006665; GO:0010628; GO:0016702; GO:0019369; GO:0019372; GO:0043410; GO:0043651; GO:0046513; GO:0051122; GO:0055114; GO:0061436; GO:0070257; GO:1990136 PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:21558561}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:21558561}. 0 0 PF00305;PF01477; P17141 CHOYP_BRAFLDRAFT_204357.1.1 m.62329 sp ZFP37_MOUSE 33.051 354 212 12 595 940 246 582 5.74E-39 159 ZFP37_MOUSE reviewed Zinc finger protein 37 (Zfp-37) (Male germ cell-specific zinc finger protein) Zfp37 Zfp-37 Mus musculus (Mouse) 594 "germ cell development [GO:0007281]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0007281; GO:0007283; GO:0008270 0 0 cd07765; PF01352;PF00096;PF13912; P48725 CHOYP_LOC100368547.26.40 m.32851 sp PCNT_MOUSE 49.565 115 40 4 27 136 2683 2784 5.74E-26 105 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; Q08DY9 CHOYP_CASP7.12.23 m.29337 sp CASP3_BOVIN 27.734 256 142 13 29 265 44 275 5.74E-16 79 CASP3_BOVIN reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) 275 erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182] GO:0005737; GO:0030182; GO:0030216; GO:0030218; GO:0097194; GO:0097200 0 0 0 0 Q0E908 CHOYP_LOC100117474.2.2 m.58862 sp HIL_DROME 24.096 498 330 13 138 620 350 814 5.74E-33 140 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q0WR59 CHOYP_Y5020.1.1 m.26498 sp Y5020_ARATH 37.857 140 70 5 227 352 393 529 5.74E-10 65.1 Y5020_ARATH reviewed Probable inactive receptor kinase At5g10020 At5g10020 T31P16.10 T31P16_9 Arabidopsis thaliana (Mouse-ear cress) 1048 0 GO:0004672; GO:0005524; GO:0005829; GO:0005886; GO:0016021 0 0 0 PF13516;PF13855;PF08263;PF00069; Q3T149 CHOYP_LOC100892767.1.1 m.5428 sp HSPB1_BOVIN 42.683 82 46 1 102 183 82 162 5.74E-16 75.5 HSPB1_BOVIN reviewed Heat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) HSPB1 HSP27 Bos taurus (Bovine) 201 0 GO:0005634; GO:0005737; GO:0005819 0 0 0 PF00011; Q5R5S1 CHOYP_LOC100373758.1.1 m.41561 sp FBX21_PONAB 34.662 577 354 11 11 570 30 600 5.74E-106 335 FBX21_PONAB reviewed F-box only protein 21 FBXO21 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 621 protein ubiquitination [GO:0016567] GO:0000151; GO:0003677; GO:0016567 0 0 0 PF13369;PF08755; Q60787 CHOYP_LCP2.14.14 m.59691 sp LCP2_MOUSE 36.885 122 74 2 556 674 402 523 5.74E-18 91.3 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q94CF0 CHOYP_BRAFLDRAFT_282105.2.2 m.59782 sp EHD1_ARATH 26.368 201 128 7 143 330 197 390 5.74E-08 58.9 EHD1_ARATH reviewed EH domain-containing protein 1 (AtEHD1) (EC 3.6.5.2) EHD1 At3g20290 MQC12.3 Arabidopsis thaliana (Mouse-ear cress) 545 endocytic recycling [GO:0032456]; endocytosis [GO:0006897]; hyperosmotic salinity response [GO:0042538]; protein homooligomerization [GO:0051260] GO:0005509; GO:0005525; GO:0005737; GO:0005768; GO:0005886; GO:0006897; GO:0009506; GO:0010008; GO:0016020; GO:0016787; GO:0032456; GO:0042538; GO:0043231; GO:0051260 0 0 0 PF00350;PF12763;PF16880; E1BBQ2 CHOYP_RADI.2.2 m.22446 sp GP158_BOVIN 27.545 167 104 5 656 820 219 370 5.75E-13 77 GP158_BOVIN reviewed Probable G-protein coupled receptor 158 GPR158 Bos taurus (Bovine) 1216 G-protein coupled receptor signaling pathway [GO:0007186]; protein localization to plasma membrane [GO:0072659]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0004930; GO:0005886; GO:0007186; GO:0008277; GO:0016021; GO:0072659 0 0 0 PF00003; E9NA96 CHOYP_LOC659899.1.1 m.34744 sp IR25A_DROME 37.634 744 379 19 76 768 66 775 5.75E-158 486 IR25A_DROME reviewed Ionotropic receptor 25a Ir25a CG15627 Drosophila melanogaster (Fruit fly) 947 detection of chemical stimulus involved in sensory perception [GO:0050907]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; rhythmic process [GO:0048511]; transmission of nerve impulse [GO:0019226] GO:0004970; GO:0005234; GO:0005886; GO:0005929; GO:0015026; GO:0015276; GO:0016021; GO:0019226; GO:0030424; GO:0043204; GO:0048511; GO:0050907; GO:0050911; GO:0071683 0 0 0 PF00060;PF10613; E9Q555 CHOYP_BRAFLDRAFT_108418.2.2 m.47715 sp RN213_MOUSE 27.19 548 313 15 228 757 1221 1700 5.75E-51 199 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O15116 CHOYP_LOC100369712.1.1 m.64282 sp LSM1_HUMAN 68.939 132 40 1 1 131 1 132 5.75E-58 179 LSM1_HUMAN reviewed U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm) LSM1 CASM Homo sapiens (Human) 133 "deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; histone mRNA catabolic process [GO:0071044]; mRNA processing [GO:0006397]; negative regulation of neuron differentiation [GO:0045665]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; stem cell population maintenance [GO:0019827]" GO:0000290; GO:0000339; GO:0000375; GO:0000932; GO:0003729; GO:0005634; GO:0005737; GO:0005829; GO:0006397; GO:0008380; GO:0019827; GO:0030424; GO:0030425; GO:0036002; GO:0043025; GO:0043928; GO:0044822; GO:0045665; GO:0071044; GO:1990124 0 0 0 PF01423; P10072 CHOYP_LOC101347770.1.1 m.42559 sp HKR1_HUMAN 36.667 60 37 1 4 63 569 627 5.75E-06 50.1 HKR1_HUMAN reviewed Krueppel-related zinc finger protein 1 (Protein HKR1) (Zinc finger protein 875) HKR1 ZNF875 Homo sapiens (Human) 659 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0046872 0 0 cd07765; PF01352;PF00096; P48159 CHOYP_RL23.2.11 m.5430 sp RL23_DROME 91.241 137 12 0 11 147 4 140 5.75E-88 255 RL23_DROME reviewed 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) 140 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0006412; GO:0007052; GO:0017022; GO:0022008; GO:0022625; GO:0070180 0 0 0 PF00238; P70031 CHOYP_LOC101076498.2.2 m.25096 sp CCKAR_XENLA 23.398 359 249 11 53 396 72 419 5.75E-20 94.7 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q03601 CHOYP_BRAFLDRAFT_206799.19.23 m.52746 sp NHL1_CAEEL 29.348 92 60 2 28 114 789 880 5.75E-07 50.8 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q4ZJM9 CHOYP_SI_RP71-1G18.9.1.2 m.4018 sp C1QL4_MOUSE 36.441 118 60 5 163 272 126 236 5.75E-10 61.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5IS75 CHOYP_ACHB.1.3 m.8510 sp ACHB3_PANTR 26.329 414 256 8 26 393 27 437 5.75E-44 162 ACHB3_PANTR reviewed Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Pan troglodytes (Chimpanzee) 458 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; Q5ZM41 CHOYP_TEX10.1.3 m.1379 sp TEX10_CHICK 23.598 428 280 12 86 470 328 751 5.75E-18 92 TEX10_CHICK reviewed Testis-expressed sequence 10 protein homolog TEX10 RCJMB04_3d16 Gallus gallus (Chicken) 927 maturation of LSU-rRNA [GO:0000470]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000470; GO:0003682; GO:0005730; GO:0016021; GO:0030174; GO:0030687; GO:0031965; GO:0071339; GO:0097344 0 0 0 PF12333; Q7L273 CHOYP_KCTD9.1.1 m.40883 sp KCTD9_HUMAN 63 100 37 0 1 100 222 321 5.75E-34 125 KCTD9_HUMAN reviewed BTB/POZ domain-containing protein KCTD9 KCTD9 Homo sapiens (Human) 389 protein homooligomerization [GO:0051260] GO:0051260 0 0 0 PF02214;PF11834;PF00805; Q8BYM7 CHOYP_YTDC2.1.1 m.58332 sp RSH4A_MOUSE 56.667 300 121 3 19 316 212 504 5.75E-106 328 RSH4A_MOUSE reviewed Radial spoke head protein 4 homolog A (Radial spoke head-like protein 3) Rsph4a Rshl3 Mus musculus (Mouse) 716 axoneme assembly [GO:0035082]; cilium movement [GO:0003341] GO:0001534; GO:0003341; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005930; GO:0035082 0 0 0 PF04712; Q8C3X4 CHOYP_GUF1.1.2 m.14878 sp GUF1_MOUSE 62.178 349 130 1 42 390 29 375 5.75E-154 452 GUF1_MOUSE reviewed "Translation factor Guf1, mitochondrial (EC 3.6.5.-) (Elongation factor 4 homolog) (EF-4) (GTPase Guf1) (Ribosomal back-translocase)" Guf1 Mus musculus (Mouse) 651 positive regulation of translation [GO:0045727]; translation [GO:0006412] GO:0003924; GO:0005525; GO:0005739; GO:0005743; GO:0005759; GO:0006412; GO:0043022; GO:0045727 0 0 0 PF00679;PF03144;PF06421; Q91VN0 CHOYP_LRP5.2.3 m.43955 sp LRP5_MOUSE 26.02 980 602 34 69 992 72 984 5.75E-79 286 LRP5_MOUSE reviewed Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7) (Lr3) Lrp5 Lrp7 Mus musculus (Mouse) 1614 "adipose tissue development [GO:0060612]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in patterning of blood vessels [GO:1902262]; bone development [GO:0060348]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling involved in mammary gland development [GO:0060764]; cell migration involved in gastrulation [GO:0042074]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; glucose catabolic process [GO:0006007]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; osteoblast development [GO:0002076]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of bone remodeling [GO:0046850]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; retinal blood vessel morphogenesis [GO:0061304]; retina morphogenesis in camera-type eye [GO:0060042]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; somatic stem cell population maintenance [GO:0035019]; vasculature development [GO:0001944]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]" GO:0001702; GO:0001944; GO:0002053; GO:0002076; GO:0005739; GO:0005783; GO:0005886; GO:0006007; GO:0006897; GO:0008203; GO:0008217; GO:0008284; GO:0009952; GO:0016021; GO:0016055; GO:0017147; GO:0033690; GO:0035019; GO:0035108; GO:0035426; GO:0042074; GO:0042632; GO:0042733; GO:0042813; GO:0042981; GO:0043235; GO:0044332; GO:0045600; GO:0045668; GO:0045840; GO:0045893; GO:0045944; GO:0046849; GO:0046850; GO:0048539; GO:0051091; GO:0060033; GO:0060042; GO:0060070; GO:0060348; GO:0060349; GO:0060444; GO:0060603; GO:0060612; GO:0060764; GO:0060828; GO:0061178; GO:0061299; GO:0061304; GO:0071901; GO:0071936; GO:1902262 0 0 0 PF00057;PF00058; Q98ST7 CHOYP_ACDOPBH.7.9 m.47783 sp MOXD1_CHICK 28.61 374 236 13 167 513 189 558 5.75E-36 145 MOXD1_CHICK reviewed DBH-like monooxygenase protein 1 (EC 1.14.17.-) (DBH-related protein) (Monooxygenase X) MOXD1 DBHR MOX Gallus gallus (Chicken) 614 0 GO:0005507; GO:0005789; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q9H9L4 CHOYP_MGC154513.1.1 m.20908 sp KANL2_HUMAN 46.216 370 180 7 27 384 28 390 5.75E-95 301 KANL2_HUMAN reviewed KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) KANSL2 C12orf41 NSL2 Homo sapiens (Human) 492 histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982] GO:0000123; GO:0005654; GO:0043981; GO:0043982; GO:0043984; GO:0044545 0 0 0 PF13891; A7YY35 CHOYP_LOC100376186.1.7 m.6887 sp K2012_BOVIN 36.22 254 156 3 1394 1642 891 1143 5.76E-25 117 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; O88572 CHOYP_LRP6.2.6 m.1956 sp LRP6_MOUSE 32.453 265 169 4 26 288 327 583 5.76E-36 145 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; P23381 CHOYP_SYWC.4.5 m.36167 sp SYWC_HUMAN 68.182 88 28 0 23 110 81 168 5.76E-37 133 SYWC_HUMAN reviewed "Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]" WARS IFI53 WRS Homo sapiens (Human) 471 angiogenesis [GO:0001525]; negative regulation of cell proliferation [GO:0008285]; regulation of angiogenesis [GO:0045765]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]; tryptophanyl-tRNA aminoacylation [GO:0006436] GO:0001525; GO:0004830; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006412; GO:0006418; GO:0006436; GO:0008285; GO:0045765; GO:0070062 0 0 0 PF00579;PF00458; P34257 CHOYP_TCB2.1.2 m.11737 sp TC3A_CAEEL 29.688 128 88 2 1 127 181 307 5.76E-16 75.5 TC3A_CAEEL reviewed Transposable element Tc3 transposase tc3a B0303.5 Caenorhabditis elegans 329 "developmental process [GO:0032502]; DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074; GO:0032502 0 0 0 PF11427;PF01498; Q03111 CHOYP_ENL.1.1 m.11664 sp ENL_HUMAN 55.392 204 79 2 6 207 5 198 5.76E-68 238 ENL_HUMAN reviewed Protein ENL (YEATS domain-containing protein 1) MLLT1 ENL LTG19 YEATS1 Homo sapiens (Human) 559 "negative regulation of protein kinase activity [GO:0006469]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006355; GO:0006366; GO:0006469; GO:0008023 0 0 0 PF03366; Q09YG9 CHOYP_LOC754728.4.6 m.41550 sp CTTB2_SAIBB 41.558 77 43 2 1 75 758 834 5.76E-10 57.8 CTTB2_SAIBB reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) 1659 0 GO:0005938; GO:0043197 0 0 0 PF12796;PF09727; Q1LZA0 CHOYP_PIGB.1.1 m.11291 sp PIGB_BOVIN 48.16 326 162 3 78 399 57 379 5.76E-104 329 PIGB_BOVIN reviewed GPI mannosyltransferase 3 (EC 2.4.1.-) (GPI mannosyltransferase III) (GPI-MT-III) (Phosphatidylinositol-glycan biosynthesis class B protein) (PIG-B) PIGB Bos taurus (Bovine) 541 GPI anchor biosynthetic process [GO:0006506] GO:0000030; GO:0005789; GO:0006506; GO:0016021 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF03901; Q24K15 CHOYP_BRAFLDRAFT_68413.1.1 m.33575 sp ANGP4_BOVIN 46.97 132 64 3 107 236 285 412 5.76E-34 130 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q25C93 CHOYP_FEZF1.1.1 m.35711 sp FEZF1_DANRE 80.583 206 33 3 225 429 224 423 5.76E-113 343 FEZF1_DANRE reviewed Fez family zinc finger protein 1 fezf1 fez Danio rerio (Zebrafish) (Brachydanio rerio) 429 "axon guidance [GO:0007411]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0001227; GO:0003677; GO:0005634; GO:0006351; GO:0007411; GO:0045892; GO:0046872 0 0 0 PF00096;PF13912; Q4R7T5 CHOYP_NEMVEDRAFT_V1G122840.1.2 m.28819 sp CDKL2_MACFA 58.968 407 151 6 1 392 1 406 5.76E-172 504 CDKL2_MACFA reviewed Cyclin-dependent kinase-like 2 (EC 2.7.11.22) CDKL2 QtsA-14426 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 570 0 GO:0004693; GO:0005524; GO:0005634; GO:0005737 0 0 0 PF00069; Q6YHK3 CHOYP_LOC100647494.1.1 m.55801 sp CD109_HUMAN 31.324 763 472 17 699 1433 679 1417 5.76E-103 363 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q7LHG5 CHOYP_LOC100374064.1.4 m.7388 sp YI31B_YEAST 30.815 1019 611 23 238 1225 513 1468 5.76E-124 424 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q8C9M2 CHOYP_LOC100376540.1.1 m.10630 sp CCD15_MOUSE 45.455 176 89 3 303 477 615 784 5.76E-30 127 CCD15_MOUSE reviewed Coiled-coil domain-containing protein 15 Ccdc15 Mus musculus (Mouse) 810 0 GO:0005813 0 0 0 0 Q9D733 CHOYP_LOC100536672.1.1 m.15537 sp GP2_MOUSE 36.364 143 72 7 149 278 38 174 5.76E-14 76.3 GP2_MOUSE reviewed Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) Gp2 Mus musculus (Mouse) 531 antigen transcytosis by M cells in mucosal-associated lymphoid tissue [GO:0002412] GO:0002412; GO:0003823; GO:0016324; GO:0031225; GO:0070062 0 0 0 PF00100; Q9H8L6 CHOYP_MMRN2.1.3 m.18122 sp MMRN2_HUMAN 32.759 116 75 2 88 203 819 931 5.76E-09 59.3 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; I1VZH0 CHOYP_NEMVEDRAFT_V1G198897.6.6 m.60895 sp RN207_RABIT 24.878 205 139 6 16 218 103 294 5.77E-11 67.4 RN207_RABIT reviewed RING finger protein 207 RNF207 Oryctolagus cuniculus (Rabbit) 594 0 GO:0005737; GO:0008270 0 0 0 PF00643; O94901 CHOYP_SUN1.2.2 m.47230 sp SUN1_HUMAN 48.8 250 120 3 536 778 564 812 5.77E-74 260 SUN1_HUMAN reviewed SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1) SUN1 KIAA0810 UNC84A Homo sapiens (Human) 812 cytoskeletal anchoring at nuclear membrane [GO:0090286]; nuclear envelope organization [GO:0006998]; nuclear matrix anchoring at nuclear membrane [GO:0090292]; ossification [GO:0001503]; response to mechanical stimulus [GO:0009612]; synapsis [GO:0007129] GO:0001503; GO:0002080; GO:0005635; GO:0005639; GO:0006998; GO:0007129; GO:0009612; GO:0031965; GO:0034993; GO:0043231; GO:0090286; GO:0090292 0 0 0 PF09387;PF07738; P37397 CHOYP_SMP_078690.1.5 m.1277 sp CNN3_RAT 47.407 135 64 4 19 150 141 271 5.77E-24 99.8 CNN3_RAT reviewed "Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform)" Cnn3 Rattus norvegicus (Rat) 330 actomyosin structure organization [GO:0031032]; epithelial cell differentiation [GO:0030855]; negative regulation of ATPase activity [GO:0032780] GO:0005737; GO:0005874; GO:0005884; GO:0005925; GO:0008017; GO:0014069; GO:0030425; GO:0030674; GO:0030855; GO:0031032; GO:0032780; GO:0043025; GO:0043197 0 0 0 PF00402;PF00307; P53369 CHOYP_LOC587752.1.1 m.66173 sp 8ODP_RAT 60.265 151 60 0 3 153 4 154 5.77E-64 196 8ODP_RAT reviewed "7,8-dihydro-8-oxoguanine triphosphatase (EC 3.6.1.55) (2-hydroxy-dATP diphosphatase) (EC 3.6.1.56) (8-oxo-dGTPase) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1)" Nudt1 Mth1 Rattus norvegicus (Rat) 156 aging [GO:0007568]; dATP catabolic process [GO:0046061]; dGTP catabolic process [GO:0006203]; DNA protection [GO:0042262]; DNA repair [GO:0006281]; male gonad development [GO:0008584]; purine nucleotide catabolic process [GO:0006195]; response to cadmium ion [GO:0046686] GO:0001669; GO:0005615; GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005886; GO:0006195; GO:0006203; GO:0006281; GO:0007568; GO:0008413; GO:0008584; GO:0030515; GO:0031965; GO:0035539; GO:0036219; GO:0042262; GO:0046061; GO:0046686; GO:0046872; GO:0047693; GO:0070062 0 0 0 PF00293; Q27874 CHOYP_PAT3.4.4 m.54228 sp PAT3_CAEEL 37.379 618 350 12 2 599 203 803 5.77E-119 379 PAT3_CAEEL reviewed Integrin beta pat-3 (Paralyzed arrest at two-fold protein 3) pat-3 ZK1058.2 Caenorhabditis elegans 809 cell adhesion [GO:0007155]; integrin-mediated signaling pathway [GO:0007229]; muscle cell development [GO:0055001]; positive regulation of distal tip cell migration [GO:1903356]; positive regulation of locomotion [GO:0040017]; positive regulation of myosin II filament organization [GO:1904901]; positive regulation of ovulation [GO:0060279]; positive regulation of smooth muscle contraction [GO:0045987]; regulation of actin cytoskeleton organization [GO:0032956] GO:0007155; GO:0007229; GO:0008305; GO:0009986; GO:0031430; GO:0032956; GO:0040017; GO:0043005; GO:0043025; GO:0045987; GO:0055001; GO:0055120; GO:0060279; GO:1903356; GO:1904901 0 0 0 PF07974;PF08725;PF07965;PF00362; Q54728 CHOYP_BRAFLDRAFT_268591.1.1 m.59744 sp Y1686_STRPN 31.905 210 126 7 15 221 6 201 5.77E-19 88.2 Y1686_STRPN reviewed Uncharacterized oxidoreductase SP_1686 (EC 1.-.-.-) SP_1686 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 367 0 GO:0016491 0 0 0 PF01408;PF02894; Q5R6Z6 CHOYP_LOC100367949.3.3 m.63228 sp RCD1_PONAB 87.361 269 34 0 17 285 11 279 5.77E-172 494 RCD1_PONAB reviewed Cell differentiation protein RCD1 homolog (Rcd-1) (CCR4-NOT transcription complex subunit 9) RQCD1 CNOT9 RCD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 299 "cytokine-mediated signaling pathway [GO:0019221]; gene silencing by RNA [GO:0031047]; mRNA catabolic process [GO:0006402]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; positive regulation of ligand-dependent nuclear receptor transcription coactivator activity [GO:2000327]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]" GO:0000932; GO:0005634; GO:0006351; GO:0006355; GO:0006402; GO:0006417; GO:0016020; GO:0019221; GO:0030014; GO:0031047; GO:0033147; GO:2000327 0 0 0 0 Q8N6T3 CHOYP_BRAFLDRAFT_123642.2.2 m.55471 sp ARFG1_HUMAN 42.217 469 192 13 1 453 1 406 5.77E-107 328 ARFG1_HUMAN reviewed ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) ARFGAP1 ARF1GAP Homo sapiens (Human) 406 "ER to Golgi vesicle-mediated transport [GO:0006888]; IRE1-mediated unfolded protein response [GO:0036498]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005096; GO:0005829; GO:0006888; GO:0006890; GO:0015031; GO:0030100; GO:0036498; GO:0045202; GO:0046872 0 0 0 PF01412; Q90YP3 CHOYP_MANL.5.9 m.42622 sp RS28_ICTPU 89.231 65 7 0 61 125 5 69 5.77E-37 123 RS28_ICTPU reviewed 40S ribosomal protein S28 rps28 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 69 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd04457; PF01200; Q9BXB1 CHOYP_LGR4.2.2 m.36403 sp LGR4_HUMAN 31.221 426 254 7 24 423 29 441 5.77E-40 159 LGR4_HUMAN reviewed Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) LGR4 GPR48 Homo sapiens (Human) 951 "bone mineralization [GO:0030282]; bone remodeling [GO:0046849]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cell differentiation involved in metanephros development [GO:0072202]; circadian regulation of gene expression [GO:0032922]; digestive tract development [GO:0048565]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; hair follicle development [GO:0001942]; innate immune response [GO:0045087]; intestinal stem cell homeostasis [GO:0036335]; male genitalia development [GO:0030539]; metanephric glomerulus development [GO:0072224]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transcription, DNA-templated [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription, DNA-templated [GO:0045893]; spermatogenesis [GO:0007283]" GO:0001649; GO:0001942; GO:0004888; GO:0004930; GO:0005886; GO:0005887; GO:0007283; GO:0030282; GO:0030539; GO:0032922; GO:0034122; GO:0036335; GO:0045087; GO:0045892; GO:0045893; GO:0046849; GO:0048565; GO:0050710; GO:0061290; GO:0072202; GO:0072224; GO:0072282; GO:0090190; GO:0090263; GO:2001013 0 0 0 PF00001;PF13855;PF01462; Q9ES30 CHOYP_BRAFLDRAFT_69138.2.2 m.62771 sp C1QT3_MOUSE 31.496 127 81 3 65 187 118 242 5.77E-09 57.4 C1QT3_MOUSE reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1qtnf3 Cors26 Ctrp3 Mus musculus (Mouse) 246 cellular triglyceride homeostasis [GO:0035356]; glucose homeostasis [GO:0042593]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of protein kinase B signaling [GO:0051897]; protein oligomerization [GO:0051259]; protein trimerization [GO:0070206] GO:0005576; GO:0005581; GO:0005615; GO:0005623; GO:0016020; GO:0035356; GO:0042347; GO:0042593; GO:0042802; GO:0045721; GO:0050715; GO:0050728; GO:0051259; GO:0051897; GO:0070062; GO:0070165; GO:0070206; GO:0070374; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9JIX0 CHOYP_LOC100374772.2.4 m.36460 sp ENY2_MOUSE 84.091 88 14 0 40 127 13 100 5.77E-51 159 ENY2_MOUSE reviewed Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog) Eny2 Mus musculus (Mouse) 101 "histone deubiquitination [GO:0016578]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of transcription, DNA-templated [GO:0045893]; protein transport [GO:0015031]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]" GO:0000124; GO:0003682; GO:0003713; GO:0005643; GO:0006357; GO:0006368; GO:0015031; GO:0016578; GO:0016973; GO:0030374; GO:0045893; GO:0061179; GO:0070390; GO:0071819 0 0 0 0 Q9UBB5 CHOYP_ISCW_ISCW010143.3.3 m.61541 sp MBD2_HUMAN 52.018 223 86 5 4 210 148 365 5.77E-71 224 MBD2_HUMAN reviewed Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2) MBD2 Homo sapiens (Human) 411 "ATP-dependent chromatin remodeling [GO:0043044]; cellular protein complex assembly [GO:0043623]; chromatin silencing at rDNA [GO:0000183]; maternal behavior [GO:0042711]; methylation-dependent chromatin silencing [GO:0006346]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of cell proliferation [GO:0042127]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000122; GO:0000183; GO:0000790; GO:0000792; GO:0003682; GO:0003696; GO:0003729; GO:0005634; GO:0005654; GO:0005737; GO:0006346; GO:0006351; GO:0008327; GO:0019904; GO:0030177; GO:0035197; GO:0042127; GO:0042711; GO:0043044; GO:0043234; GO:0043623; GO:0045892; GO:0070742 0 0 0 PF01429;PF14048;PF16564; Q9VQ93 CHOYP_GOLP3.1.1 m.52389 sp GOLP3_DROME 73.038 293 70 2 5 288 2 294 5.77E-154 434 GOLP3_DROME reviewed Golgi phosphoprotein 3 homolog sauron (Protein rotini) sau GOLPH3 l(2)s5379 rti CG7085 Drosophila melanogaster (Fruit fly) 294 "actomyosin contractile ring assembly [GO:0000915]; cleavage furrow formation [GO:0036089]; Golgi organization [GO:0007030]; male meiosis cytokinesis [GO:0007112]; meiosis I cytokinesis [GO:0007110]; meiosis II cytokinesis [GO:0007111]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly [GO:0090307]; protein transport [GO:0015031]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; smoothened signaling pathway [GO:0007224]; spindle assembly [GO:0051225]; spindle assembly involved in male meiosis [GO:0007053]" GO:0000139; GO:0000281; GO:0000301; GO:0000915; GO:0005794; GO:0007030; GO:0007053; GO:0007110; GO:0007111; GO:0007112; GO:0007224; GO:0010314; GO:0015031; GO:0016023; GO:0017137; GO:0031985; GO:0032154; GO:0032266; GO:0036089; GO:0051225; GO:0070273; GO:0070300; GO:0090307 0 0 0 PF05719; A4IF63 CHOYP_BRAFLDRAFT_87306.1.4 m.3211 sp TRIM2_BOVIN 24.766 214 112 7 213 425 538 703 5.78E-09 62 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O18756 CHOYP_LOC100370244.3.4 m.52580 sp GLCE_BOVIN 47.328 524 264 6 84 602 101 617 5.78E-176 515 GLCE_BOVIN reviewed D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) GLCE Bos taurus (Bovine) 617 heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] GO:0000139; GO:0005794; GO:0015012; GO:0016021; GO:0016857; GO:0030210; GO:0047464; GO:0050379 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis. 0 0 PF06662; O57592 CHOYP_LOC100366813.6.6 m.44802 sp RL7A_TAKRU 76 225 52 1 22 246 44 266 5.78E-127 363 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O75382 CHOYP_BRAFLDRAFT_85511.11.23 m.33096 sp TRIM3_HUMAN 21.942 278 182 10 254 512 483 744 5.78E-09 62.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0C6A0 CHOYP_LOC101160291.1.1 m.14540 sp ZGLP1_HUMAN 37.805 164 80 4 261 418 118 265 5.78E-26 109 ZGLP1_HUMAN reviewed GATA-type zinc finger protein 1 (GATA-like protein 1) (GLP-1) ZGLP1 GLP1 Homo sapiens (Human) 271 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; oocyte development [GO:0048599]; spermatogenesis [GO:0007283] GO:0000122; GO:0000977; GO:0001085; GO:0001228; GO:0003682; GO:0005634; GO:0005667; GO:0007275; GO:0007283; GO:0008270; GO:0030154; GO:0048599 0 0 0 PF00320; P10079 CHOYP_LOC575027.1.6 m.21079 sp FBP1_STRPU 52.347 426 197 5 97 519 454 876 5.78E-138 427 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11620 CHOYP_DVIR_GJ12112.1.3 m.1998 sp YPT1_SCHPO 37.288 177 102 6 39 213 9 178 5.78E-26 103 YPT1_SCHPO reviewed GTP-binding protein ypt1 ypt1 SPBC1703.10 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 203 autophagy [GO:0006914]; negative regulation of G0 to G1 transition [GO:0070317]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0003924; GO:0005525; GO:0005634; GO:0005789; GO:0005829; GO:0006914; GO:0007264; GO:0015031; GO:0034045; GO:0070317 0 0 0 PF00071; P18106 CHOYP_LOC594826.1.1 m.25127 sp FER_DROME 36.339 366 220 6 955 1309 955 1318 5.78E-61 233 FER_DROME reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) FER fps Fps85D HD-179 CG8874 Drosophila melanogaster (Fruit fly) 1325 "actin filament bundle assembly [GO:0051017]; axon guidance [GO:0007411]; dorsal closure [GO:0007391]; dorsal closure, amnioserosa morphology change [GO:0046664]; dorsal closure, elongation of leading edge cells [GO:0007394]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]" GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005543; GO:0005886; GO:0005912; GO:0006468; GO:0007169; GO:0007391; GO:0007394; GO:0007411; GO:0019898; GO:0031234; GO:0038083; GO:0042127; GO:0045087; GO:0046664; GO:0051017 0 0 0 PF00611;PF07714;PF00017; P42674 CHOYP_LOC100377541.3.4 m.27246 sp BP10_PARLI 31.266 403 243 14 130 522 71 449 5.78E-44 167 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P70031 CHOYP_BRAFLDRAFT_66653.1.2 m.4846 sp CCKAR_XENLA 22.277 404 281 15 7 389 32 423 5.78E-09 61.2 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q13395 CHOYP_LOC100700626.2.2 m.17262 sp TARB1_HUMAN 29.054 1363 859 31 276 1537 265 1620 5.78E-158 524 TARB1_HUMAN reviewed Probable methyltransferase TARBP1 (EC 2.1.1.-) (TAR RNA-binding protein 1) (TAR RNA-binding protein of 185 kDa) (TRP-185) TARBP1 TRM3 TRP185 Homo sapiens (Human) 1621 regulation of transcription from RNA polymerase II promoter [GO:0006357]; tRNA methylation [GO:0030488] GO:0003723; GO:0005634; GO:0006357; GO:0016423; GO:0030488 0 0 0 PF00588; Q16566 CHOYP_CAMK4.1.1 m.30431 sp KCC4_HUMAN 60 305 121 1 8 312 31 334 5.78E-137 400 KCC4_HUMAN reviewed Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) CAMK4 CAMK CAMK-GR CAMKIV Homo sapiens (Human) 473 "adaptive immune response [GO:0002250]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of osteoclast differentiation [GO:0045670]; regulation of T cell differentiation in thymus [GO:0033081]; signal transduction [GO:0007165]" GO:0002250; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006468; GO:0006954; GO:0007165; GO:0007616; GO:0009931; GO:0018105; GO:0033081; GO:0035556; GO:0043011; GO:0045670; GO:0045893; GO:0046777; GO:0070062 0 0 0 PF00069; Q1L994 CHOYP_PPR37.1.1 m.27483 sp PPR37_DANRE 52.347 426 194 4 70 493 192 610 5.78E-147 459 PPR37_DANRE reviewed Protein phosphatase 1 regulatory subunit 37 (Leucine-rich repeat-containing protein 68) ppp1r37 lrrc68 si:ch211-234g24.1 Danio rerio (Zebrafish) (Brachydanio rerio) 919 negative regulation of phosphatase activity [GO:0010923] GO:0004864; GO:0010923; GO:0019902 0 0 0 PF13516; Q3V1N1 CHOYP_TLR3.6.6 m.65942 sp MFHA1_MOUSE 29.565 115 76 2 184 298 58 167 5.78E-07 55.1 MFHA1_MOUSE reviewed Malignant fibrous histiocytoma-amplified sequence 1 homolog Mfhas1 Mus musculus (Mouse) 1048 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF13855;PF08477; Q5DRD0 CHOYP_contig_042627 m.49113 sp PCDB4_PANTR 27.891 441 249 19 79 480 185 595 5.78E-21 100 PCDB4_PANTR reviewed Protocadherin beta-4 (PCDH-beta-4) PCDHB4 Pan troglodytes (Chimpanzee) 795 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005737; GO:0005886; GO:0007156; GO:0016021; GO:0045111 0 0 0 PF00028;PF08266;PF16492; Q5ZIN1 CHOYP_RBM22.1.1 m.43648 sp NUDC_CHICK 45.113 133 66 2 2 134 8 133 5.78E-28 109 NUDC_CHICK reviewed Nuclear migration protein nudC (Nuclear distribution protein C homolog) NUDC RCJMB04_24m10 Gallus gallus (Chicken) 341 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005737; GO:0005874; GO:0007067; GO:0051301 0 0 0 PF04969;PF16273;PF14050; Q6AYH2 CHOYP_BRAFLDRAFT_114734.7.8 m.50127 sp IN80E_RAT 64.13 92 27 2 14 99 8 99 5.78E-26 103 IN80E_RAT reviewed INO80 complex subunit E (Coiled-coil domain-containing protein 95) Ino80e Ccdc95 Rattus norvegicus (Rat) 244 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005730; GO:0006260; GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0031011 0 0 0 0 Q9WU63 CHOYP_HEBP2.1.2 m.48089 sp HEBP2_MOUSE 29.016 193 106 7 38 228 35 198 5.78E-13 68.6 HEBP2_MOUSE reviewed Heme-binding protein 2 (Protein SOUL) Hebp2 Soul Mus musculus (Mouse) 205 negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of necrotic cell death [GO:0010940] GO:0005737; GO:0005739; GO:0010917; GO:0010940; GO:0035794; GO:0070062 0 0 0 PF04832; B5X7E4 CHOYP_LOC100368907.1.1 m.22004 sp IF43B_SALSA 41.627 209 114 3 1 208 1 202 5.79E-46 154 IF43B_SALSA reviewed Intraflagellar transport protein 43 homolog B ift43b Salmo salar (Atlantic salmon) 215 cilium morphogenesis [GO:0060271]; intraciliary retrograde transport [GO:0035721] GO:0005929; GO:0030991; GO:0035721; GO:0060271 0 0 0 PF15305; C9J6K1 CHOYP_CS081.1.1 m.48577 sp CS081_HUMAN 30.769 91 57 2 198 282 63 153 5.79E-07 52.8 CS081_HUMAN reviewed Putative uncharacterized protein C19orf81 C19orf81 Homo sapiens (Human) 198 0 0 0 0 0 PF15876; Q02290 CHOYP_contig_041263 m.47053 sp XYNB_NEOPA 25.581 344 256 0 4 347 451 794 5.79E-27 115 XYNB_NEOPA reviewed "Endo-1,4-beta-xylanase B (Xylanase B) (EC 3.2.1.8) (1,4-beta-D-xylan xylanohydrolase B)" xynB Neocallimastix patriciarum (Rumen fungus) 860 xylan catabolic process [GO:0045493] GO:0005576; GO:0030248; GO:0031176; GO:0045493 PATHWAY: Glycan degradation; xylan degradation. 0 0 PF00734;PF00331; Q07837 CHOYP_SLC31.4.5 m.43504 sp SLC31_HUMAN 40.5 200 113 2 35 228 182 381 5.79E-50 176 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q148V8 CHOYP_AGAP_AGAP007349.1.5 m.2718 sp FA83H_MOUSE 43.939 66 37 0 33 98 861 926 5.79E-06 47.4 FA83H_MOUSE reviewed Protein FAM83H Fam83h Mus musculus (Mouse) 1209 biomineral tissue development [GO:0031214]; intermediate filament cytoskeleton organization [GO:0045104]; positive regulation of cell migration [GO:0030335]; protein localization to cytoskeleton [GO:0044380] GO:0005737; GO:0019901; GO:0030335; GO:0031214; GO:0044380; GO:0045095; GO:0045104; GO:1990254 0 0 0 PF07894; Q1PSW8 CHOYP_BRAFLDRAFT_88223.2.22 m.14538 sp LIN41_MOUSE 21.704 493 302 21 63 527 259 695 5.79E-11 68.9 LIN41_MOUSE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (mLin41) (Tripartite motif-containing protein 71) Trim71 Gm1127 Lin41 Mus musculus (Mouse) 855 3'-UTR-mediated mRNA destabilization [GO:0061158]; cellular response to organic substance [GO:0071310]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; regulation of protein metabolic process [GO:0051246]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0017148; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051246; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0071310; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q460N5 CHOYP_PAR14.13.17 m.57656 sp PAR14_HUMAN 31.748 652 391 15 585 1228 1195 1800 5.79E-78 287 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q502M6 CHOYP_TVAG_099270.4.6 m.54149 sp ANR29_DANRE 37.126 167 105 0 193 359 62 228 5.79E-25 106 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5PR73 CHOYP_LOC100371150.1.1 m.48549 sp DIRA2_MOUSE 40.994 161 93 1 9 169 9 167 5.79E-37 131 DIRA2_MOUSE reviewed GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2) Diras2 Mus musculus (Mouse) 199 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264 0 0 0 PF00071; Q6UIM1 CHOYP_BRAFLDRAFT_113877.1.1 m.27198 sp ZNHI3_MACMU 39.716 141 74 4 20 151 2 140 5.79E-21 86.7 ZNHI3_MACMU reviewed Zinc finger HIT domain-containing protein 3 (Thyroid hormone receptor interactor 3) (Thyroid receptor-interacting protein 3) (TR-interacting protein 3) (TRIP-3) (Fragment) ZNHIT3 TRIP3 Macaca mulatta (Rhesus macaque) 147 0 GO:0046872 0 0 0 PF04438; Q80V70 CHOYP_CED1.23.29 m.49745 sp MEGF6_MOUSE 25.994 704 354 33 194 768 906 1571 5.79E-20 99.4 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q96M86 CHOYP_LOC100376274.4.7 m.33238 sp DNHD1_HUMAN 23.501 1234 789 30 15 1178 660 1808 5.79E-75 285 DNHD1_HUMAN reviewed Dynein heavy chain domain-containing protein 1 (Dynein heavy chain domain 1-like protein) (Protein CCDC35) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) 4753 microtubule-based movement [GO:0007018] GO:0003777; GO:0007018; GO:0030286; GO:0070062 0 0 0 PF08393;PF03028;PF12777; Q9WVM7 CHOYP_LOC575132.1.2 m.1649 sp AIMP2_CRIGR 32.117 274 158 6 9 262 54 319 5.79E-37 135 AIMP2_CRIGR reviewed Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) AIMP2 JTV1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 320 apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; translation [GO:0006412] GO:0005634; GO:0005829; GO:0006412; GO:0006915; GO:0007275; GO:0030154 0 0 0 PF16780;PF00043; A0A0R4IBK5 CHOYP_BRAFLDRAFT_106560.1.14 m.4931 sp R213A_DANRE 30.419 1121 646 36 80 1115 2429 3500 5.80E-125 442 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 B3EWZ6 CHOYP_MDGA2.1.2 m.5344 sp MLRP2_ACRMI 36.129 155 96 3 17 168 889 1043 5.80E-22 95.9 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B9EJ86 CHOYP_OSBL8.1.2 m.7583 sp OSBL8_MOUSE 57.186 334 119 7 56 367 101 432 5.80E-119 368 OSBL8_MOUSE reviewed Oxysterol-binding protein-related protein 8 (ORP-8) (OSBP-related protein 8) Osbpl8 Kiaa1451 Orp8 Mus musculus (Mouse) 889 activation of protein kinase B activity [GO:0032148]; fat cell differentiation [GO:0045444]; negative regulation of cell migration [GO:0030336]; negative regulation of sequestering of triglyceride [GO:0010891]; phospholipid transport [GO:0015914]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of protein kinase B signaling [GO:0051897]; protein localization to nuclear pore [GO:0090204] GO:0001786; GO:0005548; GO:0005789; GO:0010891; GO:0015485; GO:0015914; GO:0016020; GO:0016021; GO:0030336; GO:0031965; GO:0032148; GO:0032541; GO:0045444; GO:0046628; GO:0051897; GO:0070273; GO:0090204; GO:2001275 0 0 0 PF01237;PF00169; O18326 CHOYP_HB.1.1 m.8391 sp HUNB_BOMMO 58.192 177 66 1 281 457 198 366 5.80E-62 219 HUNB_BOMMO reviewed Protein hunchback (Fragment) hb Bombyx mori (Silk moth) 385 "regulation of development, heterochronic [GO:0040034]; segmentation [GO:0035282]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003677; GO:0005634; GO:0006351; GO:0035282; GO:0040034; GO:0046872 0 0 0 0 P10394 CHOYP_contig_000441 m.425 sp POL4_DROME 35.204 196 121 1 135 324 270 465 5.80E-34 135 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P20693 CHOYP_ASGR2.1.4 m.4187 sp FCER2_MOUSE 34.437 151 82 5 10 157 171 307 5.80E-20 87.8 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P42577 CHOYP_LOC100881468.1.1 m.61701 sp FRIS_LYMST 83.626 171 28 0 1 171 1 171 5.80E-106 303 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P48148 CHOYP_AAEL_AAEL013139.2.2 m.63703 sp RHO1_DROME 65.054 186 63 1 1 186 1 184 5.80E-86 255 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; P86854 CHOYP_LOC100485485.1.1 m.27961 sp PLCL_MYTGA 31.061 132 85 4 61 190 29 156 5.80E-16 74.7 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P9WIT3 CHOYP_PNAP_0598.1.2 m.52942 sp GULDH_MYCTU 20.534 487 321 14 107 591 5 427 5.80E-11 68.6 GULDH_MYCTU reviewed "L-gulono-1,4-lactone dehydrogenase (EC 1.1.2.-)" Rv1771 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 428 L-ascorbic acid biosynthetic process [GO:0019853] GO:0003885; GO:0005618; GO:0005886; GO:0019853; GO:0050660; GO:0080049 PATHWAY: Cofactor biosynthesis; L-ascorbate biosynthesis. {ECO:0000269|PubMed:16956367}. 0 0 PF04030;PF01565; Q04637 CHOYP_IF4G1.1.2 m.36813 sp IF4G1_HUMAN 53.02 298 129 5 411 697 725 1022 5.80E-88 305 IF4G1_HUMAN reviewed Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) EIF4G1 EIF4F EIF4G EIF4GI Homo sapiens (Human) 1599 "behavioral fear response [GO:0001662]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of neuron differentiation [GO:0045666]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]; viral process [GO:0016032]" GO:0000184; GO:0000289; GO:0001662; GO:0003743; GO:0005737; GO:0005829; GO:0005913; GO:0006413; GO:0006446; GO:0008135; GO:0008190; GO:0016020; GO:0016032; GO:0016281; GO:0043488; GO:0044822; GO:0045666; GO:0098641 0 0 0 PF02847;PF02854;PF02020; Q24372 CHOYP_HMCN2.10.12 m.49343 sp LACH_DROME 31.27 307 180 11 281 579 39 322 5.80E-32 130 LACH_DROME reviewed Lachesin Lac CG12369 Drosophila melanogaster (Fruit fly) 359 "cell adhesion involved in heart morphogenesis [GO:0061343]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; morphogenesis of embryonic epithelium [GO:0016331]; open tracheal system development [GO:0007424]; regulation of tube size, open tracheal system [GO:0035151]; septate junction assembly [GO:0019991]" GO:0005886; GO:0005918; GO:0007156; GO:0007424; GO:0016331; GO:0019991; GO:0031225; GO:0035151; GO:0035160; GO:0042803; GO:0061343 0 0 0 PF07679; Q8BMJ7 CHOYP_MYC.2.2 m.47338 sp CGRF1_MOUSE 26.198 313 211 10 22 329 21 318 5.80E-23 102 CGRF1_MOUSE reviewed Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) Cgrrf1 Cgr19 Mus musculus (Mouse) 332 cell cycle arrest [GO:0007050] GO:0005654; GO:0007050; GO:0008270; GO:0043231 0 0 0 0 Q8C6L5 CHOYP_NEMVEDRAFT_V1G218264.10.14 m.51527 sp CGAS_MOUSE 27.564 156 93 5 173 311 328 480 5.80E-08 59.3 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q92051 CHOYP_LOC576041.1.1 m.28220 sp CAHZ_DANRE 42.164 268 137 11 21 280 2 259 5.80E-58 190 CAHZ_DANRE reviewed Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) cahz cah-z Danio rerio (Zebrafish) (Brachydanio rerio) 260 carbon dioxide transport [GO:0015670]; hypotonic salinity response [GO:0042539]; one-carbon metabolic process [GO:0006730] GO:0004089; GO:0006730; GO:0008270; GO:0015670; GO:0042539 0 0 0 PF00194; Q9CQZ5 CHOYP_LOC101070737.2.3 m.11531 sp NDUA6_MOUSE 56.757 111 48 0 33 143 21 131 5.80E-42 138 NDUA6_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (NADH-ubiquinone oxidoreductase B14 subunit) Ndufa6 Mus musculus (Mouse) 131 oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005747; GO:0006979; GO:0031966; GO:0055114 0 0 0 PF05347; Q9H7H0 CHOYP_LOC100709610.1.1 m.939 sp MET17_HUMAN 31.347 453 262 11 80 520 24 439 5.80E-73 243 MET17_HUMAN reviewed "Methyltransferase-like protein 17, mitochondrial (EC 2.1.1.-) (False p73 target gene protein) (Methyltransferase 11 domain-containing protein 1) (Protein RSM22 homolog, mitochondrial)" METTL17 METT11D1 Homo sapiens (Human) 456 aerobic respiration [GO:0009060]; respiratory chain complex IV assembly [GO:0008535]; translation [GO:0006412] GO:0005507; GO:0005634; GO:0005654; GO:0005739; GO:0005840; GO:0006412; GO:0008168; GO:0008535; GO:0009060 0 0 0 PF09243; Q9JHA8 CHOYP_LOC101165910.1.1 m.59982 sp VWA7_MOUSE 25.17 588 377 21 72 632 91 642 5.80E-27 122 VWA7_MOUSE reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) 891 0 GO:0005576 0 0 0 0 A5YM72 CHOYP_CRNS1.1.1 m.65328 sp CRNS1_HUMAN 32.056 287 183 7 15 290 65 350 5.81E-24 105 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A6H7E2 CHOYP_CINP.1.1 m.16121 sp CINP_BOVIN 34.314 204 113 5 28 214 10 209 5.81E-31 115 CINP_BOVIN reviewed Cyclin-dependent kinase 2-interacting protein CINP Bos taurus (Bovine) 212 cell cycle [GO:0007049]; cell division [GO:0051301]; DNA repair [GO:0006281]; DNA replication [GO:0006260] GO:0005634; GO:0006260; GO:0006281; GO:0007049; GO:0051301 0 0 0 0 O43301 CHOYP_BRAFLDRAFT_208293.9.20 m.44068 sp HS12A_HUMAN 35.354 198 124 2 1 194 476 673 5.81E-36 135 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P06603 CHOYP_LOC754102.1.1 m.57574 sp TBA1_DROME 99.275 138 1 0 57 194 89 226 5.81E-96 288 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P0C0W8 CHOYP_LOC100876937.1.1 m.10567 sp GP139_RAT 27.692 260 140 14 54 301 102 325 5.81E-14 75.1 GP139_RAT reviewed Probable G-protein coupled receptor 139 (G(q)-coupled orphan receptor GPRg1) Gpr139 Gprg1 Rattus norvegicus (Rat) 345 phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200] GO:0005886; GO:0007200; GO:0008188; GO:0016021 0 0 0 PF00001; P10079 CHOYP_BRAFLDRAFT_203370.1.1 m.42886 sp FBP1_STRPU 43.167 461 257 4 373 832 261 717 5.81E-116 380 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P41593 CHOYP_LOC100556910.1.1 m.14573 sp PTH1R_MOUSE 28.571 378 234 10 43 397 108 472 5.81E-45 167 PTH1R_MOUSE reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) Pth1r Pthr Pthr1 Mus musculus (Mouse) 591 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; aging [GO:0007568]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; cell maturation [GO:0048469]; cell surface receptor signaling pathway [GO:0007166]; cellular calcium ion homeostasis [GO:0006874]; chondrocyte differentiation [GO:0002062]; negative regulation of cell proliferation [GO:0008285]; ossification [GO:0001503]; osteoblast development [GO:0002076]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; skeletal system development [GO:0001501] GO:0001501; GO:0001503; GO:0002062; GO:0002076; GO:0004991; GO:0005622; GO:0005634; GO:0005829; GO:0005887; GO:0006874; GO:0007166; GO:0007188; GO:0007189; GO:0007200; GO:0007204; GO:0007568; GO:0008284; GO:0008285; GO:0016323; GO:0016324; GO:0017046; GO:0030282; GO:0031526; GO:0043235; GO:0043621; GO:0045453; GO:0048469; GO:0060732; GO:0070062 0 0 0 PF00002;PF02793; P78412 CHOYP_IRO.2.4 m.10201 sp IRX6_HUMAN 59.259 108 41 2 164 268 133 240 5.81E-33 133 IRX6_HUMAN reviewed Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6) IRX6 IRX7 IRXB3 Homo sapiens (Human) 446 "regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0043565 0 0 0 PF05920; Q25010 CHOYP_ACT3.3.3 m.66907 sp ACT3A_HELAM 81.57 293 5 1 1 293 133 376 5.81E-169 476 ACT3A_HELAM reviewed "Actin, cytoplasmic A3a" actA3a Helicoverpa armigera (Cotton bollworm) (Heliothis armigera) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q5BIM1 CHOYP_BRAFLDRAFT_86868.1.2 m.24995 sp TRI45_BOVIN 22.467 454 282 9 262 661 36 473 5.81E-24 110 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5VYJ5 CHOYP_NEMVEDRAFT_V1G138161.1.1 m.30414 sp MALR1_HUMAN 35.882 170 98 6 82 241 849 1017 5.81E-23 100 MALR1_HUMAN reviewed MAM and LDL-receptor class A domain-containing protein 1 MALRD1 C10orf112 DIET1 Homo sapiens (Human) 2156 cholesterol homeostasis [GO:0042632]; negative regulation of bile acid biosynthetic process [GO:0070858] GO:0016021; GO:0030659; GO:0042632; GO:0070858 0 0 cd06263; PF00008;PF00057;PF00629; Q80X44 CHOYP_ZBT49.1.1 m.9308 sp ZBT24_MOUSE 31.551 187 115 5 11 196 337 511 5.81E-24 105 ZBT24_MOUSE reviewed Zinc finger and BTB domain-containing protein 24 (Bone morphogenetic protein-induced factor 1) (Brain-specific protein 1) (Zinc finger protein 450) Zbtb24 Bif1 Bsg1 Znf450 Mus musculus (Mouse) 710 "hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0002244; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF00096;PF13912; Q9CZJ2 CHOYP_LOC100374651.2.4 m.34410 sp HS12B_MOUSE 29.645 479 274 9 8 433 61 529 5.81E-61 213 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9H0J9 CHOYP_PARP12.1.2 m.42887 sp PAR12_HUMAN 31.165 738 422 24 124 841 6 677 5.81E-98 323 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9HCM2 CHOYP_PLXNB2.2.4 m.42942 sp PLXA4_HUMAN 26.385 1967 1192 78 37 1866 47 1894 5.81E-163 550 PLXA4_HUMAN reviewed Plexin-A4 PLXNA4 KIAA1550 PLXNA4A PLXNA4B UNQ2820/PRO34003 Homo sapiens (Human) 1894 anterior commissure morphogenesis [GO:0021960]; branchiomotor neuron axon guidance [GO:0021785]; chemorepulsion of branchiomotor axon [GO:0021793]; facial nerve structural organization [GO:0021612]; glossopharyngeal nerve morphogenesis [GO:0021615]; postganglionic parasympathetic fiber development [GO:0021784]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; regulation of negative chemotaxis [GO:0050923]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; sympathetic nervous system development [GO:0048485]; trigeminal nerve structural organization [GO:0021637]; vagus nerve morphogenesis [GO:0021644] GO:0002116; GO:0005886; GO:0005887; GO:0017154; GO:0021612; GO:0021615; GO:0021637; GO:0021644; GO:0021784; GO:0021785; GO:0021793; GO:0021960; GO:0030334; GO:0048485; GO:0048841; GO:0050923; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; Q9SA71 CHOYP_BRAFLDRAFT_81240.1.1 m.54953 sp GLPT3_ARATH 27.294 436 265 14 6 393 33 464 5.81E-36 141 GLPT3_ARATH reviewed Putative glycerol-3-phosphate transporter 3 (G-3-P transporter 3) (Glycerol-3-phosphate permease 3) (AtG3Pp3) (G-3-P permease 3) At1g30560 T5I8.1 Arabidopsis thaliana (Mouse-ear cress) 510 anion transport [GO:0006820]; carbohydrate transport [GO:0008643]; phosphate ion homeostasis [GO:0055062]; transmembrane transport [GO:0055085] GO:0006820; GO:0008643; GO:0016021; GO:0022857; GO:0055062; GO:0055085 0 0 cd06174; PF07690; A5PJ65 CHOYP_RER1.1.1 m.49089 sp RER1_BOVIN 68.449 187 57 1 25 211 9 193 5.82E-94 275 RER1_BOVIN reviewed Protein RER1 RER1 Bos taurus (Bovine) 196 "retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0006890; GO:0016021 0 0 0 PF03248; B3EWY7 CHOYP_NEMVEDRAFT_V1G246686.1.1 m.53126 sp ASOMP_ACRMI 31.818 242 136 7 51 264 84 324 5.82E-30 119 ASOMP_ACRMI reviewed Acidic skeletal organic matrix protein (Acidic SOMP) 0 Acropora millepora (Staghorn coral) 359 0 GO:0005576 0 0 0 0 O88658 CHOYP_LOC100169592.1.1 m.29028 sp KIF1B_RAT 50 452 168 12 6 408 812 1254 5.82E-127 406 KIF1B_RAT reviewed Kinesin-like protein KIF1B Kif1b Rattus norvegicus (Rat) 1816 anterograde axonal transport [GO:0008089]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; mitochondrion transport along microtubule [GO:0047497]; neuromuscular synaptic transmission [GO:0007274]; neuron-neuron synaptic transmission [GO:0007270] GO:0003777; GO:0005524; GO:0005739; GO:0005871; GO:0005874; GO:0005875; GO:0007018; GO:0007270; GO:0007274; GO:0008089; GO:0016887; GO:0030659; GO:0030705; GO:0031410; GO:0043005; GO:0047497; GO:1904115 0 0 0 PF12473;PF00498;PF12423;PF00225;PF16183;PF00169; O95714 CHOYP_LOC100370069.5.14 m.36409 sp HERC2_HUMAN 29.167 144 87 3 236 368 1793 1932 5.82E-10 66.6 HERC2_HUMAN reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) HERC2 Homo sapiens (Human) 4834 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair via nonhomologous end joining [GO:0006303]; intracellular protein transport [GO:0006886]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005085; GO:0005634; GO:0005654; GO:0005737; GO:0005743; GO:0005814; GO:0006303; GO:0006886; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016925; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; P02720 CHOYP_BRAFLDRAFT_270293.1.3 m.8709 sp PPCT_BOVIN 55.208 192 84 1 27 216 19 210 5.82E-79 239 PPCT_BOVIN reviewed Phosphatidylcholine transfer protein (PC-TP) (START domain-containing protein 2) (StARD2) (StAR-related lipid transfer protein 2) PCTP STARD2 Bos taurus (Bovine) 213 phospholipid transport [GO:0015914] GO:0005737; GO:0008289; GO:0008525; GO:0015914; GO:0031210 0 0 0 PF01852; P10394 CHOYP_POL4.1.4 m.8082 sp POL4_DROME 28.811 1253 795 28 12 1238 55 1236 5.82E-142 469 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P19419 CHOYP_ISCW_ISCW009238.1.1 m.24963 sp ELK1_HUMAN 64.348 115 33 3 42 148 1 115 5.82E-43 157 ELK1_HUMAN reviewed ETS domain-containing protein Elk-1 ELK1 Homo sapiens (Human) 428 "cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to testosterone stimulus [GO:0071394]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to fibroblast growth factor [GO:0071774]; response to light stimulus [GO:0009416]" GO:0000978; GO:0001047; GO:0001077; GO:0001085; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005739; GO:0009416; GO:0030154; GO:0030425; GO:0043025; GO:0043679; GO:0045893; GO:0045944; GO:0071394; GO:0071480; GO:0071774; GO:1901216 0 0 0 PF00178; P41824 CHOYP_LOC100370246.2.2 m.45834 sp YBOXH_APLCA 76.86 121 18 1 51 161 1 121 5.82E-58 190 YBOXH_APLCA reviewed Y-box factor homolog (APY1) 0 Aplysia californica (California sea hare) 253 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005634; GO:0006351; GO:0006355 0 0 cd04458; PF00313; P59222 CHOYP_LOC100370489.1.4 m.37791 sp SREC2_MOUSE 40.506 79 44 1 185 260 261 339 5.82E-08 57 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; Q00560 CHOYP_CPIPJ_CPIJ017416.1.1 m.11252 sp IL6RB_MOUSE 23.11 463 282 19 231 661 219 639 5.82E-07 57.8 IL6RB_MOUSE reviewed Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) Il6st Mus musculus (Mouse) 917 ciliary neurotrophic factor-mediated signaling pathway [GO:0070120]; cytokine-mediated signaling pathway [GO:0019221]; glycogen metabolic process [GO:0005977]; interleukin-11-mediated signaling pathway [GO:0038154]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-6-mediated signaling pathway [GO:0070102]; leukemia inhibitory factor signaling pathway [GO:0048861]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of cell proliferation [GO:0008284]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tyrosine phosphorylation of Stat1 protein [GO:0042511]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; regulation of Notch signaling pathway [GO:0008593]; response to cytokine [GO:0034097]; signal transduction [GO:0007165] GO:0004897; GO:0004915; GO:0004923; GO:0004924; GO:0005127; GO:0005615; GO:0005896; GO:0005900; GO:0005977; GO:0007165; GO:0008284; GO:0008593; GO:0009897; GO:0016020; GO:0019221; GO:0019838; GO:0030425; GO:0034097; GO:0038154; GO:0038165; GO:0042102; GO:0042511; GO:0042517; GO:0043025; GO:0044297; GO:0045669; GO:0048711; GO:0048861; GO:0070062; GO:0070102; GO:0070104; GO:0070106; GO:0070110; GO:0070120 0 0 0 PF00041;PF09240;PF06328; Q3U288 CHOYP_LOC100119315.1.1 m.59339 sp ZN710_MOUSE 35.714 98 57 3 375 471 466 558 5.82E-07 55.8 ZN710_MOUSE reviewed Zinc finger protein 710 Znf710 Zfp710 Mus musculus (Mouse) 666 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003712; GO:0005634; GO:0006351; GO:0006357; GO:0046872 0 0 0 PF13912; Q3ZBE6 CHOYP_TM135.1.1 m.8221 sp TM135_BOVIN 45.969 459 227 5 1 445 1 452 5.82E-139 409 TM135_BOVIN reviewed Transmembrane protein 135 TMEM135 Bos taurus (Bovine) 458 0 GO:0005777; GO:0016021 0 0 0 PF02466;PF15982; Q55E58 CHOYP_LOC100313668.1.6 m.23636 sp PATS1_DICDI 21.909 461 288 17 743 1196 1792 2187 5.82E-22 107 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5ND28 CHOYP_contig_037019 m.41692 sp SREC_MOUSE 32.963 270 146 16 202 457 153 401 5.82E-17 87.4 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q8TCT0 CHOYP_CERKL.4.4 m.64884 sp CERK1_HUMAN 32.468 231 154 2 67 295 81 311 5.82E-36 142 CERK1_HUMAN reviewed Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) CERK KIAA1646 Homo sapiens (Human) 537 ceramide metabolic process [GO:0006672]; glycosphingolipid metabolic process [GO:0006687] GO:0000287; GO:0001729; GO:0005524; GO:0005739; GO:0005886; GO:0006672; GO:0006687; GO:0016021 0 0 0 PF00781; Q9CPY7 CHOYP_SEC61G.3.3 m.59281 sp AMPL_MOUSE 36.607 112 71 0 3 114 59 170 5.82E-18 81.3 AMPL_MOUSE reviewed Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) Lap3 Lapep Mus musculus (Mouse) 519 0 GO:0004177; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005802; GO:0005925; GO:0008233; GO:0008235; GO:0030145; GO:0070062 0 0 cd00433; PF00883;PF02789; Q9QYJ6 CHOYP_BRAFLDRAFT_83680.1.1 m.4634 sp PDE10_RAT 30.222 225 149 5 33 254 21 240 5.82E-22 98.2 PDE10_RAT reviewed "cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35)" Pde10a Rattus norvegicus (Rat) 794 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; regulation of cAMP-mediated signaling [GO:0043949]; regulation of protein kinase A signaling [GO:0010738]; signal transduction [GO:0007165] GO:0004112; GO:0004118; GO:0005737; GO:0006198; GO:0007165; GO:0008144; GO:0010738; GO:0016020; GO:0030552; GO:0030553; GO:0043025; GO:0043204; GO:0043949; GO:0046069; GO:0046872; GO:0047555 "PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.; PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1." 0 0 PF01590;PF00233; Q9VZW5 CHOYP_AAEL_AAEL015604.1.1 m.6434 sp FMAR_DROME 27.523 327 219 5 42 362 103 417 5.82E-34 137 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; A9ULZ2 CHOYP_XIAP.5.7 m.46805 sp BIR7B_XENLA 33.466 251 107 5 26 272 37 231 5.83E-34 130 BIR7B_XENLA reviewed Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) 345 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; O08629 CHOYP_LOC100376307.2.2 m.62429 sp TIF1B_RAT 20.619 194 137 6 11 204 117 293 5.83E-07 52.8 TIF1B_RAT reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (Nuclear corepressor KAP-1) (Tripartite motif-containing protein 28) Trim28 Kap1 Tif1b Rattus norvegicus (Rat) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]" GO:0001105; GO:0001837; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; P0CT43 CHOYP_LOC100493440.1.2 m.17291 sp TF28_SCHPO 20.961 458 299 17 113 555 422 831 5.83E-08 59.7 TF28_SCHPO reviewed Transposon Tf2-8 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-8 Tf2-9 SPAC13D1.02c SPAC19D5.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P20693 CHOYP_FCER2.1.9 m.2786 sp FCER2_MOUSE 35.461 141 79 6 22 160 186 316 5.83E-16 76.6 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P82198 CHOYP_BRAFLDRAFT_127065.4.7 m.28277 sp BGH3_MOUSE 35.102 245 148 8 47 286 136 374 5.83E-35 136 BGH3_MOUSE reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) Tgfbi Mus musculus (Mouse) 683 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198] GO:0001525; GO:0002062; GO:0005518; GO:0005578; GO:0005604; GO:0005615; GO:0005802; GO:0007155; GO:0008283; GO:0030198; GO:0050839; GO:0050840; GO:0070062 0 0 0 PF02469; Q15459 CHOYP_SF3A1.2.3 m.46631 sp SF3A1_HUMAN 59.509 163 62 3 21 181 385 545 5.83E-56 191 SF3A1_HUMAN reviewed Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114) SF3A1 SAP114 Homo sapiens (Human) 793 "mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]" GO:0000381; GO:0000389; GO:0000398; GO:0003723; GO:0005654; GO:0005681; GO:0005684; GO:0005686; GO:0006397; GO:0044822; GO:0071004; GO:0071013 0 0 0 PF12230;PF01805;PF00240; Q460N5 CHOYP_PAR14.2.17 m.19746 sp PAR14_HUMAN 53.205 156 71 2 2 157 1647 1800 5.83E-41 149 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q8BGB5 CHOYP_LOC100563867.1.1 m.11836 sp LIMD2_MOUSE 42.857 112 63 1 23 133 17 128 5.83E-28 102 LIMD2_MOUSE reviewed LIM domain-containing protein 2 Limd2 Mus musculus (Mouse) 128 0 GO:0008270 0 0 0 PF00412; Q8VEL2 CHOYP_MTMRE.1.1 m.13570 sp MTMRE_MOUSE 46.285 646 271 19 14 608 28 648 5.83E-171 504 MTMRE_MOUSE reviewed Myotubularin-related protein 14 (EC 3.1.3.-) (mJumpy) Mtmr14 Mus musculus (Mouse) 648 0 GO:0001726; GO:0004438; GO:0004725; GO:0048471 0 0 0 0 Q9CZJ2 CHOYP_HS12A.28.33 m.61122 sp HS12B_MOUSE 33.438 317 157 10 11 274 61 376 5.83E-37 141 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_105410.1.1 m.20547 sp TRIM2_MOUSE 26.699 206 135 7 58 257 536 731 5.83E-10 63.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9QY73 CHOYP_LOC100377241.1.1 m.43620 sp TMM59_MOUSE 30.645 310 176 10 37 331 33 318 5.83E-35 132 TMM59_MOUSE reviewed Transmembrane protein 59 (Thymic dendritic cell-derived factor 1) Tmem59 ORF18 Tdcf1 Mus musculus (Mouse) 323 autophagy [GO:0006914]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of protein glycosylation in Golgi [GO:0090285]; negative regulation of protein processing [GO:0010955]; positive regulation of autophagy [GO:0010508] GO:0000137; GO:0000138; GO:0000139; GO:0004175; GO:0005764; GO:0005765; GO:0005770; GO:0005797; GO:0005886; GO:0006914; GO:0010508; GO:0010955; GO:0016021; GO:0031902; GO:0070062; GO:0090005; GO:0090285 0 0 0 PF12280; Q9WVM7 CHOYP_LOC575132.2.2 m.66125 sp AIMP2_CRIGR 31.193 327 188 9 52 351 3 319 5.83E-42 151 AIMP2_CRIGR reviewed Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1) AIMP2 JTV1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 320 apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; translation [GO:0006412] GO:0005634; GO:0005829; GO:0006412; GO:0006915; GO:0007275; GO:0030154 0 0 0 PF16780;PF00043; Q9Y0I1 CHOYP_MO4L1.1.1 m.8106 sp EAF3_DROME 39.955 443 220 10 32 469 22 423 5.83E-89 280 EAF3_DROME reviewed NuA4 complex subunit EAF3 homolog (Protein MRG15) MRG15 CG6363 Drosophila melanogaster (Fruit fly) 424 "chromatin modification [GO:0016568]; chromatin silencing [GO:0006342]; chromosome organization [GO:0051276]; chromosome separation [GO:0051304]; DNA repair [GO:0006281]; histone acetylation [GO:0016573]; histone deacetylation [GO:0016575]; histone exchange [GO:0043486]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0005634; GO:0006281; GO:0006342; GO:0006351; GO:0016568; GO:0016573; GO:0016575; GO:0035064; GO:0035267; GO:0043486; GO:0043967; GO:0043968; GO:0051276; GO:0051304 0 0 0 PF05712;PF11717; A4IG32 CHOYP_LOC552081.1.1 m.51439 sp MICU1_DANRE 58.252 412 157 5 121 525 80 483 5.84E-163 474 MICU1_DANRE reviewed "Calcium uptake protein 1, mitochondrial (Calcium-binding atopy-related autoantigen 1 homolog)" micu1 cbara1 si:ch211-199i24.4 zgc:162148 Danio rerio (Zebrafish) (Brachydanio rerio) 489 calcium ion import [GO:0070509]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; positive regulation of mitochondrial calcium ion concentration [GO:0051561] GO:0005509; GO:0005743; GO:0005758; GO:0006851; GO:0032592; GO:0051560; GO:0051561; GO:0070509; GO:1990246 0 0 0 PF13202;PF13833; D3ZAT9 CHOYP_LOC100377010.12.16 m.56470 sp FAXC_RAT 35.681 213 121 4 1 202 128 335 5.84E-42 149 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; O43301 CHOYP_BRAFLDRAFT_208436.14.32 m.45861 sp HS12A_HUMAN 28.305 537 319 12 5 481 129 659 5.84E-74 249 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O95861 CHOYP_BRAFLDRAFT_285264.1.1 m.52913 sp BPNT1_HUMAN 53.746 307 139 3 1 305 1 306 5.84E-118 347 BPNT1_HUMAN reviewed "3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)" BPNT1 Homo sapiens (Human) 308 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; phosphatidylinositol phosphorylation [GO:0046854] GO:0000287; GO:0004441; GO:0005737; GO:0005829; GO:0006139; GO:0007399; GO:0008441; GO:0046854; GO:0050427; GO:0070062 0 0 0 PF00459; P0CT39 CHOYP_contig_001932 m.2146 sp TF26_SCHPO 26.138 681 443 17 1 640 540 1201 5.84E-60 223 TF26_SCHPO reviewed Transposon Tf2-6 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-6 SPAC27E2.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P17972 CHOYP_KCNC4.2.5 m.18635 sp KCNAW_DROME 37.079 445 235 9 60 487 8 424 5.84E-87 280 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P53563 CHOYP_contig_032447 m.37025 sp B2CL1_RAT 31.776 107 62 4 470 567 89 193 5.84E-06 51.2 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; Q0VCP9 CHOYP_LOC100344710.1.1 m.66195 sp CC149_BOVIN 49.324 296 143 3 59 352 1 291 5.84E-82 260 CC149_BOVIN reviewed Coiled-coil domain-containing protein 149 CCDC149 Bos taurus (Bovine) 319 0 GO:0016021 0 0 0 PF09789; Q17RB8 CHOYP_LONRF1.1.1 m.61768 sp LONF1_HUMAN 35.897 780 367 19 47 762 62 772 5.84E-138 428 LONF1_HUMAN reviewed LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191) LONRF1 RNF191 Homo sapiens (Human) 773 protein polyubiquitination [GO:0000209] GO:0000209; GO:0004176; GO:0004842; GO:0005829; GO:0008270 0 0 0 PF02190;PF13445; Q29HY3 CHOYP_CDC42.1.11 m.325 sp CDC42_DROPS 91.573 178 15 0 8 185 14 191 5.84E-121 342 CDC42_DROPS reviewed Cdc42 homolog Cdc42 GA11680 Drosophila pseudoobscura pseudoobscura (Fruit fly) 191 maintenance of protein location [GO:0045185]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275; GO:0045185; GO:0045860 0 0 0 PF00071; Q61EX6 CHOYP_LOC100377541.4.4 m.60673 sp NAS36_CAEBR 32.718 379 218 17 149 513 124 479 5.84E-40 159 NAS36_CAEBR reviewed Zinc metalloproteinase nas-36 (EC 3.4.24.21) (Nematode astacin 36) nas-36 CBG11886 Caenorhabditis briggsae 616 "molting cycle, collagen and cuticulin-based cuticle [GO:0018996]; multicellular organism development [GO:0007275]" GO:0004222; GO:0005576; GO:0007275; GO:0008270; GO:0018996 0 0 0 PF01400;PF00431;PF00090; Q803T2 CHOYP_LOC100366965.2.2 m.54530 sp STRP1_DANRE 78.413 315 68 0 2 316 419 733 5.84E-169 492 STRP1_DANRE reviewed Striatin-interacting protein 1 homolog strip1 fam40a Danio rerio (Zebrafish) (Brachydanio rerio) 813 cortical actin cytoskeleton organization [GO:0030866]; heart contraction [GO:0060047]; regulation of cell morphogenesis [GO:0022604] GO:0005737; GO:0022604; GO:0030866; GO:0060047 0 0 0 PF11882;PF07923; Q8R0M8 CHOYP_DANA_MCT1.1.1 m.2202 sp MOT5_MOUSE 29.893 562 318 12 20 581 14 499 5.84E-78 258 MOT5_MOUSE reviewed Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) 500 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; Q8WZ42 CHOYP_LOC100375089.1.1 m.1340 sp TITIN_HUMAN 30.62 258 166 7 40 292 24681 24930 5.84E-22 100 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q95KG7 CHOYP_MANS1.1.1 m.49065 sp MANS1_MACFA 33.333 90 60 0 45 134 339 428 5.84E-07 50.4 MANS1_MACFA reviewed MANSC domain-containing protein 1 MANSC1 QtrA-13483 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 431 0 GO:0016021 0 0 0 PF07502; Q96RW7 CHOYP_BRAFLDRAFT_88566.8.11 m.28561 sp HMCN1_HUMAN 47.119 295 156 0 8 302 4575 4869 5.84E-91 303 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BV29 CHOYP_contig_055775 m.66401 sp CO057_HUMAN 43.636 55 30 1 6 60 63 116 5.84E-06 46.6 CO057_HUMAN reviewed Uncharacterized protein C15orf57 (Protein CCDC32) C15orf57 CCDC32 Homo sapiens (Human) 185 0 0 0 0 0 PF14989; Q9D1C2 CHOYP_BRAFLDRAFT_59498.1.2 m.19232 sp CBY1_MOUSE 55.039 129 54 3 1 127 1 127 5.84E-40 132 CBY1_MOUSE reviewed "Protein chibby homolog 1 (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)" Cby1 Cby Pgea1 Mus musculus (Mouse) 127 "cardiac muscle cell differentiation [GO:0055007]; cilium assembly [GO:0042384]; fat cell differentiation [GO:0045444]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of Wnt signaling pathway [GO:0030178]; protein localization [GO:0008104]" GO:0005634; GO:0005802; GO:0008013; GO:0008104; GO:0016607; GO:0030178; GO:0036064; GO:0042384; GO:0042802; GO:0045444; GO:0045892; GO:0055007; GO:0090090 0 0 0 PF14645; Q9NYQ8 CHOYP_PCDH1.3.3 m.63887 sp FAT2_HUMAN 27.642 123 83 2 1 117 3332 3454 5.84E-09 56.2 FAT2_HUMAN reviewed Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) FAT2 CDHF8 KIAA0811 MEGF1 Homo sapiens (Human) 4349 epithelial cell migration [GO:0010631]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005634; GO:0005886; GO:0005913; GO:0007156; GO:0010631; GO:0016021; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q9QXW9 CHOYP_LOC100904518.1.1 m.53104 sp LAT2_MOUSE 53.586 502 224 5 5 498 3 503 5.84E-174 503 LAT2_MOUSE reviewed Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (mLAT2) (Solute carrier family 7 member 8) Slc7a8 Lat2 Mus musculus (Mouse) 531 amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; neutral amino acid transport [GO:0015804] GO:0005275; GO:0005737; GO:0005886; GO:0005887; GO:0006865; GO:0015101; GO:0015171; GO:0015175; GO:0015179; GO:0015297; GO:0015804; GO:0015807; GO:0016323; GO:0019534; GO:0070062 0 0 0 PF13520; Q9U489 CHOYP_BRAFLDRAFT_102372.1.2 m.42049 sp LIN41_CAEEL 24.561 171 106 5 222 381 848 1006 5.84E-07 55.5 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9Y264 CHOYP_FIBB.1.3 m.43343 sp ANGP4_HUMAN 42.857 252 132 4 94 338 254 500 5.84E-61 207 ANGP4_HUMAN reviewed Angiopoietin-4 (ANG-4) (Angiopoietin-3) (ANG-3) ANGPT4 ANG3 ANG4 Homo sapiens (Human) 503 angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; Notch signaling pathway [GO:0007219]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731] GO:0001525; GO:0005576; GO:0005615; GO:0007219; GO:0010595; GO:0016525; GO:0030297; GO:0030971; GO:0043066; GO:0043536; GO:0043537; GO:0045766; GO:0050731; GO:0050900; GO:0071456 0 0 0 PF00147; Q9ZW86 CHOYP_DICPUDRAFT_80174.1.1 m.15029 sp P4H1_ARATH 22.222 225 126 7 45 249 76 271 5.84E-06 50.4 P4H1_ARATH reviewed Prolyl 4-hydroxylase 1 (AtP4H-1) (AtP4H1) (EC 1.14.11.2) P4H1 At2g43080 MFL8 Arabidopsis thaliana (Mouse-ear cress) 283 peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401] GO:0004656; GO:0005506; GO:0005789; GO:0005794; GO:0016021; GO:0018401; GO:0031418 0 0 0 PF13640; P42573 CHOYP_LOAG_03664.1.1 m.48895 sp CED3_CAEEL 32.313 294 174 10 242 522 215 496 5.85E-34 137 CED3_CAEEL reviewed Cell death protein 3 (EC 3.4.22.-) [Cleaved into: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] ced-3 C48D1.2 Caenorhabditis elegans 503 apoptotic process [GO:0006915]; apoptotic process involved in development [GO:1902742]; embryo development ending in birth or egg hatching [GO:0009792]; execution phase of apoptosis [GO:0097194]; programmed cell death [GO:0012501]; protein autoprocessing [GO:0016540]; protein catabolic process [GO:0030163]; regulation of apoptotic process [GO:0042981]; regulation of cell adhesion [GO:0030155] GO:0004175; GO:0004197; GO:0005737; GO:0006915; GO:0009792; GO:0012501; GO:0016020; GO:0016540; GO:0030155; GO:0030163; GO:0042802; GO:0042981; GO:0048471; GO:0097194; GO:0097200; GO:1902742 0 0 0 PF00619; P74148 CHOYP_NEMVEDRAFT_V1G242153.1.4 m.7718 sp Y1388_SYNY3 26.852 108 75 1 51 158 51 154 5.85E-11 60.8 Y1388_SYNY3 reviewed Universal stress protein Sll1388 (USP Sll1388) sll1388 Synechocystis sp. (strain PCC 6803 / Kazusa) 154 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q15399 CHOYP_LOC100647659.1.1 m.41847 sp TLR1_HUMAN 39.252 107 62 3 54 159 636 740 5.85E-11 68.6 TLR1_HUMAN reviewed Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) 786 cellular response to triacyl bacterial lipopeptide [GO:0071727]; defense response to bacterium [GO:0042742]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; toll-like receptor 1 signaling pathway [GO:0034130]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0016020; GO:0030670; GO:0034130; GO:0035354; GO:0035663; GO:0038123; GO:0042116; GO:0042495; GO:0042535; GO:0042742; GO:0045087; GO:0045121; GO:0045410; GO:0046982; GO:0050707; GO:0071723; GO:0071727 0 0 0 PF13855;PF01463;PF01582; Q2V2M9 CHOYP_FHOD3.2.2 m.44837 sp FHOD3_HUMAN 53.142 557 228 13 1830 2365 864 1408 5.85E-166 555 FHOD3_HUMAN reviewed FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) FHOD3 FHOS2 KIAA1695 Homo sapiens (Human) 1422 actin filament network formation [GO:0051639]; cardiac myofibril assembly [GO:0055003]; negative regulation of actin filament polymerization [GO:0030837]; sarcomere organization [GO:0045214] GO:0005856; GO:0030018; GO:0030837; GO:0045214; GO:0051639; GO:0055003 0 0 0 PF02181; Q3UF64 CHOYP_LOC100375947.1.1 m.32080 sp RNFT2_MOUSE 36.875 320 178 7 120 421 132 445 5.85E-65 217 RNFT2_MOUSE reviewed RING finger and transmembrane domain-containing protein 2 (Transmembrane protein 118) Rnft2 Tmem118 Mus musculus (Mouse) 445 0 GO:0008270; GO:0016021 0 0 0 0 Q3UIR3 CHOYP_BRAFLDRAFT_91316.1.1 m.46558 sp DTX3L_MOUSE 51.128 133 64 1 1189 1321 616 747 5.85E-34 144 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q64731 CHOYP_LOC100147110.1.1 m.29509 sp FOXL1_MOUSE 65.926 135 36 1 64 198 43 167 5.85E-58 195 FOXL1_MOUSE reviewed Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6) Foxl1 Fkh6 Fkhl11 Mus musculus (Mouse) 336 "heart development [GO:0007507]; Peyer's patch morphogenesis [GO:0061146]; proteoglycan biosynthetic process [GO:0030166]; regulation of transcription, DNA-templated [GO:0006355]; regulation of Wnt signaling pathway [GO:0030111]; transcription, DNA-templated [GO:0006351]; visceral mesoderm-endoderm interaction involved in midgut development [GO:0007495]" GO:0000981; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0007495; GO:0007507; GO:0030111; GO:0030166; GO:0043565; GO:0061146 0 0 0 PF00250; Q80WT5 CHOYP_LOC100376520.1.1 m.986 sp AFTIN_MOUSE 35 120 43 5 1 95 807 916 5.85E-07 49.3 AFTIN_MOUSE reviewed Aftiphilin Aftph Afth Mus musculus (Mouse) 931 intracellular transport [GO:0046907]; protein transport [GO:0015031] GO:0005634; GO:0005654; GO:0005737; GO:0005794; GO:0005829; GO:0015031; GO:0030121; GO:0030276; GO:0043231; GO:0046907 0 0 0 PF15045; Q8WZ42 CHOYP_UNC89.11.19 m.38611 sp TITIN_HUMAN 29.885 261 149 12 28 275 5761 6000 5.85E-06 54.7 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q9H2Y7 CHOYP_ZNF106.1.1 m.13975 sp ZN106_HUMAN 32.394 355 228 6 1223 1571 1527 1875 5.85E-52 206 ZN106_HUMAN reviewed Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) ZNF106 SH3BP3 ZFP106 ZNF474 Homo sapiens (Human) 1883 insulin receptor signaling pathway [GO:0008286] GO:0005730; GO:0005829; GO:0008286; GO:0016020; GO:0017124; GO:0044822; GO:0046872 0 0 0 PF00400; G9JJU2 CHOYP_GPX3.1.2 m.24838 sp GPX_PROCL 47.826 138 70 2 2 138 34 170 5.86E-40 135 GPX_PROCL reviewed Glutathione peroxidase (PcGPx) (Se-PcGPx) (EC 1.11.1.9) GPx Procambarus clarkii (Red swamp crayfish) 172 response to oxidative stress [GO:0006979] GO:0004602; GO:0006979 0 0 cd00340; PF00255; P0CT39 CHOYP_LOC100709668.1.1 m.16459 sp TF26_SCHPO 27.357 859 556 20 380 1193 368 1203 5.86E-86 311 TF26_SCHPO reviewed Transposon Tf2-6 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-6 SPAC27E2.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P32240 CHOYP_PE2R4.5.5 m.58403 sp PE2R4_MOUSE 35.925 373 191 7 7 335 5 373 5.86E-62 213 PE2R4_MOUSE reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) Ptger4 Ptgerep4 Mus musculus (Mouse) 513 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005887; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0030278; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; Q53G44 CHOYP_BRAFLDRAFT_91636.5.11 m.46840 sp IF44L_HUMAN 33.208 265 173 3 258 520 173 435 5.86E-42 159 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5TW90 CHOYP_MB21L.1.1 m.35723 sp MAB21_ANOGA 24.111 253 166 8 92 329 87 328 5.86E-10 63.2 MAB21_ANOGA reviewed Protein mab-21 mab-21 AGAP001034 Anopheles gambiae (African malaria mosquito) 365 0 0 0 0 0 PF03281; Q6JHU9 CHOYP_CBP.1.4 m.5868 sp CBP_RAT 61.039 154 37 5 56 190 286 435 5.86E-39 149 CBP_RAT reviewed CREB-binding protein (EC 2.3.1.48) Crebbp Cbp Rattus norvegicus (Rat) 2442 "cell-cell adhesion [GO:0098609]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; histone acetylation [GO:0016573]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to interleukin-1 [GO:0070555]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000123; GO:0003682; GO:0003684; GO:0003713; GO:0004402; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0008283; GO:0016407; GO:0016573; GO:0016604; GO:0033613; GO:0034644; GO:0042975; GO:0043234; GO:0043426; GO:0045893; GO:0045944; GO:0046332; GO:0048511; GO:0060355; GO:0070555; GO:0098609; GO:1900087; GO:1901224 0 0 cd15802; PF00439;PF09030;PF06001;PF08214;PF02172;PF02135;PF00569; Q6PIX5 CHOYP_RHDF1.2.3 m.45435 sp RHDF1_MOUSE 28.814 354 182 12 549 851 381 715 5.86E-32 137 RHDF1_MOUSE reviewed Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid family member 1) Rhbdf1 Dist1 Irhom1 Kiaa4242 Mus musculus (Mouse) 856 cell migration [GO:0016477]; cell proliferation [GO:0008283]; negative regulation of protein secretion [GO:0050709]; proteolysis [GO:0006508]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708] GO:0000139; GO:0005789; GO:0006508; GO:0008283; GO:0016021; GO:0016477; GO:0042058; GO:0050708; GO:0050709; GO:0061136 0 0 0 PF01694;PF12595; Q91W90 CHOYP_LOC660338.1.1 m.33595 sp TXND5_MOUSE 46.486 370 186 4 29 390 52 417 5.86E-121 359 TXND5_MOUSE reviewed Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Plasma cell-specific thioredoxin-related protein) (PC-TRP) (Thioredoxin-like protein p46) Txndc5 Tlp46 Mus musculus (Mouse) 417 apoptotic cell clearance [GO:0043277]; cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005788; GO:0006457; GO:0034976; GO:0043277; GO:0045454; GO:0070062 0 0 0 PF00085; Q9DDJ0 CHOYP_UBC9B.1.1 m.10688 sp UBC9B_DANRE 87.097 155 20 0 1 155 1 155 5.86E-104 297 UBC9B_DANRE reviewed SUMO-conjugating enzyme UBC9-B (EC 6.3.2.-) (SUMO-protein ligase B) (Ubiquitin carrier protein 9-B) (Ubiquitin carrier protein I-B) (Ubiquitin-conjugating enzyme E2 I-B) (Ubiquitin-protein ligase I-B) ube2ib ubc9b ube2i2 Danio rerio (Zebrafish) (Brachydanio rerio) 157 cell division [GO:0051301]; chromosome segregation [GO:0007059]; definitive hemopoiesis [GO:0060216]; mitotic nuclear division [GO:0007067]; protein sumoylation [GO:0016925] GO:0005524; GO:0005634; GO:0005737; GO:0007059; GO:0007067; GO:0016874; GO:0016925; GO:0019789; GO:0051301; GO:0060216 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00179; A8KBL7 CHOYP_LOC101075807.1.1 m.30761 sp MEL2A_DANRE 66.563 320 91 4 69 373 31 349 5.87E-156 446 MEL2A_DANRE reviewed Methyltransferase-like protein 2-A (EC 2.1.1.-) mettl2a mettl2 zgc:110598 Danio rerio (Zebrafish) (Brachydanio rerio) 353 tRNA methylation [GO:0030488] GO:0016427; GO:0030488 0 0 0 0 D9IQ16 CHOYP_LOC100185953.1.2 m.25807 sp GXN_ACRMI 27.465 284 168 10 57 319 44 310 5.87E-15 79.7 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 G3V801 CHOYP_DMBT1.10.34 m.21106 sp NETR_RAT 52.941 102 47 1 29 130 166 266 5.87E-29 117 NETR_RAT reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) Prss12 Rattus norvegicus (Rat) 761 exocytosis [GO:0006887]; zymogen activation [GO:0031638] GO:0004252; GO:0005044; GO:0005886; GO:0006887; GO:0030424; GO:0030425; GO:0031410; GO:0031638; GO:0043083; GO:0043195 0 0 cd00190; PF00051;PF00530;PF00089; O75943 CHOYP_LOC582037.1.1 m.64268 sp RAD17_HUMAN 41.721 616 316 11 37 619 8 613 5.87E-157 471 RAD17_HUMAN reviewed Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) RAD17 R24L Homo sapiens (Human) 681 cellular response to DNA damage stimulus [GO:0006974]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication checkpoint [GO:0000076]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of DNA replication [GO:0008156]; regulation of phosphorylation [GO:0042325]; regulation of signal transduction by p53 class mediator [GO:1901796] GO:0000076; GO:0000077; GO:0003689; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006260; GO:0006281; GO:0006974; GO:0007093; GO:0008156; GO:0031389; GO:0042325; GO:1901796 0 0 0 0 P08928 CHOYP_LMNB2.1.1 m.55999 sp LAM0_DROME 37.543 578 329 7 39 599 18 580 5.87E-122 377 LAM0_DROME reviewed Lamin Dm0 Lam CG6944 Drosophila melanogaster (Fruit fly) 622 "adult locomotory behavior [GO:0008344]; cell aging [GO:0007569]; central nervous system development [GO:0007417]; centrosome organization [GO:0051297]; chitin-based cuticle development [GO:0040003]; chromatin silencing [GO:0006342]; compound eye morphogenesis [GO:0001745]; digestive tract morphogenesis [GO:0048546]; gonad morphogenesis [GO:0035262]; heterochromatin maintenance involved in chromatin silencing [GO:0070870]; lateral inhibition [GO:0046331]; mitotic nuclear envelope reassembly [GO:0007084]; negative regulation of cell proliferation [GO:0008285]; negative regulation of immune response [GO:0050777]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; nuclear migration [GO:0007097]; nuclear pore distribution [GO:0031081]; nucleus organization [GO:0006997]; protein localization to nuclear envelope [GO:0090435]; spermatogenesis [GO:0007283]; terminal branching, open tracheal system [GO:0007430]" GO:0000922; GO:0001745; GO:0005102; GO:0005198; GO:0005634; GO:0005635; GO:0005637; GO:0005638; GO:0005652; GO:0005737; GO:0005811; GO:0005813; GO:0005875; GO:0006342; GO:0006997; GO:0006998; GO:0007084; GO:0007097; GO:0007283; GO:0007417; GO:0007430; GO:0007569; GO:0008285; GO:0008344; GO:0031081; GO:0035262; GO:0040003; GO:0046331; GO:0048546; GO:0050777; GO:0051297; GO:0070870; GO:0071763; GO:0072686; GO:0090435 0 0 0 PF00038;PF00932; P42664 CHOYP_UVS2.1.1 m.10305 sp UVS2_XENLA 30.216 139 81 4 14 142 378 510 5.87E-08 55.5 UVS2_XENLA reviewed Embryonic protein UVS.2 (EC 3.4.24.-) 0 Xenopus laevis (African clawed frog) 514 0 GO:0004222; GO:0008270 0 0 0 PF01400;PF00431; P50131 CHOYP_PE2R2.2.2 m.48937 sp PE2R3_PIG 25.61 328 210 8 13 310 20 343 5.87E-19 89.7 PE2R3_PIG reviewed Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (Prostanoid EP3 receptor) PTGER3 Sus scrofa (Pig) 373 inflammatory response [GO:0006954]; intestine smooth muscle contraction [GO:0014827]; negative regulation of gastric acid secretion [GO:0060455]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0004957; GO:0005887; GO:0006954; GO:0007200; GO:0007204; GO:0014827; GO:0060455 0 0 0 PF00001; Q24JV9 CHOYP_LRRX1.5.11 m.33926 sp L3BPA_DANRE 50.943 106 51 1 875 979 27 132 5.87E-29 126 L3BPA_DANRE reviewed Galectin-3-binding protein A (Lectin galactoside-binding soluble 3-binding protein A) lgals3bpa lgals3bp zgc:136780 Danio rerio (Zebrafish) (Brachydanio rerio) 567 cell adhesion [GO:0007155] GO:0005044; GO:0005578; GO:0007155; GO:0016020 0 0 0 PF07707;PF00651;PF00530; Q26636 CHOYP_LOC575203.2.6 m.6856 sp CATL_SARPE 57.632 321 126 5 19 330 20 339 5.87E-128 372 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q5JS54 CHOYP_LOC100489682.1.1 m.45803 sp PSMG4_HUMAN 42.342 111 58 3 27 133 15 123 5.87E-24 92.4 PSMG4_HUMAN reviewed Proteasome assembly chaperone 4 (PAC-4) (hPAC4) PSMG4 C6orf86 PAC4 Homo sapiens (Human) 123 proteasome assembly [GO:0043248] GO:0043248 0 0 0 PF16093; Q5R4B2 CHOYP_LOC100165581.1.1 m.18008 sp ARMX1_PONAB 22.078 231 156 4 322 551 201 408 5.87E-11 68.6 ARMX1_PONAB reviewed Armadillo repeat-containing X-linked protein 1 ARMCX1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 453 0 GO:0016021 0 0 0 PF04826; Q5XTS1 CHOYP_LOC726656.1.1 m.4804 sp PLPL8_RABIT 42.056 428 245 3 209 634 343 769 5.87E-123 386 PLPL8_RABIT reviewed Calcium-independent phospholipase A2-gamma (EC 3.1.1.5) (Group VIB calcium-independent phospholipase A2) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (Patatin-like phospholipase domain-containing protein 8) PNPLA8 Oryctolagus cuniculus (Rabbit) 786 lipid catabolic process [GO:0016042] GO:0000139; GO:0004622; GO:0005789; GO:0016021; GO:0016042; GO:0048471 0 0 0 PF01734; Q60997 CHOYP_LOC583353.1.1 m.37518 sp DMBT1_MOUSE 55.34 103 43 2 1 102 329 429 5.87E-23 107 DMBT1_MOUSE reviewed Deleted in malignant brain tumors 1 protein (Apactin) (CRP-ductin) (Glycoprotein 300) (gp300) (Hensin) (Mucin-like glycoprotein) (Muclin) (Vomeroglandin) (p80) Dmbt1 Crpd Mus musculus (Mouse) 2085 blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; inner cell mass cell proliferation [GO:0001833]; positive regulation of epithelial cell differentiation [GO:0030858]; protein transport [GO:0015031] GO:0001824; GO:0001833; GO:0005044; GO:0005578; GO:0005615; GO:0005622; GO:0005737; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0030670; GO:0030858; GO:0035375; GO:0042589; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q61097 CHOYP_LOC100121463.1.1 m.25001 sp KSR1_MOUSE 34.659 880 439 21 12 836 32 830 5.87E-141 442 KSR1_MOUSE reviewed Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) Ksr1 Ksr Mus musculus (Mouse) 873 cAMP-mediated signaling [GO:0019933]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] GO:0004672; GO:0005078; GO:0005524; GO:0005783; GO:0005789; GO:0007265; GO:0008022; GO:0016020; GO:0019933; GO:0032587; GO:0043234; GO:0043410; GO:0046872 0 0 0 PF13543;PF07714; Q8BGW2 CHOYP_contig_012629 m.14537 sp WBP1L_MOUSE 39.655 58 32 2 33 90 17 71 5.87E-08 53.5 WBP1L_MOUSE reviewed WW domain binding protein 1-like (Outcome predictor in acute leukemia 1 homolog) Wbp1l D19Wsu162e Opal1 Mus musculus (Mouse) 348 0 GO:0016021 0 0 0 PF11669; Q8IYB1 CHOYP_LOC100377311.12.14 m.55340 sp M21D2_HUMAN 26.286 175 108 6 82 249 225 385 5.87E-08 59.3 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8K385 CHOYP_DFP.1.1 m.31016 sp FRRS1_MOUSE 27.404 208 113 10 4 203 5 182 5.87E-07 53.9 FRRS1_MOUSE reviewed Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2) FRRS1 Sdfr2 Sdr2 Mus musculus (Mouse) 592 0 GO:0000293; GO:0016021; GO:0046872 0 0 cd08544; PF03351;PF02014; Q9MYM7 CHOYP_B3GT1.2.2 m.56750 sp B3GT1_PONPY 39.773 264 148 5 136 396 61 316 5.87E-59 197 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9UMZ3 CHOYP_LOC663785.3.3 m.58222 sp PTPRQ_HUMAN 27.4 427 261 17 258 654 68 475 5.87E-14 80.5 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; O93567 CHOYP_PRDM5.1.2 m.38512 sp ZBT7A_CHICK 27.451 153 99 4 12 160 16 160 5.88E-07 56.2 ZBT7A_CHICK reviewed Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma-related factor) (cLRF) ZBTB7A LRF ZBTB7 Gallus gallus (Chicken) 546 "transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0001078; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00651;PF00096; O94673 CHOYP_LOC578858.1.2 m.7425 sp YG75_SCHPO 28.214 280 188 7 52 321 100 376 5.88E-27 112 YG75_SCHPO reviewed Uncharacterized membrane protein C776.05 SPBC776.05 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 403 0 GO:0000139; GO:0005783; GO:0005789; GO:0005794; GO:0016021; GO:0022857 0 0 0 PF10998; P16354 CHOYP_LOC100149324.1.1 m.5536 sp PA23_HELSU 47.619 105 55 0 133 237 1 105 5.88E-29 110 PA23_HELSU reviewed Phospholipase A2 isozymes PA3A/PA3B/PA5 (PLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) 0 Heloderma suspectum (Gila monster) 143 lipid catabolic process [GO:0016042] GO:0004623; GO:0005576; GO:0016042; GO:0046872 0 0 0 PF05826; P86947 CHOYP_DERE_GG18317.1.1 m.44729 sp VRP_PINMA 47.887 142 59 5 1 140 1 129 5.88E-20 86.3 VRP_PINMA reviewed Valine-rich protein (Alveolin-like protein) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 238 0 GO:0005576 0 0 0 0 P98106 CHOYP_BRAFLDRAFT_201271.1.1 m.4376 sp LYAM3_RAT 28.758 306 176 14 214 507 87 362 5.88E-20 97.1 LYAM3_RAT reviewed P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P) Selp Rattus norvegicus (Rat) 768 leukocyte migration [GO:0050900]; positive regulation of cell adhesion [GO:0045785]; regulation of cellular extravasation [GO:0002691]; response to lipopolysaccharide [GO:0032496]; response to organic cyclic compound [GO:0014070]; single organismal cell-cell adhesion [GO:0016337] GO:0002691; GO:0005615; GO:0009897; GO:0014070; GO:0016021; GO:0016337; GO:0030246; GO:0032496; GO:0045785; GO:0050900 0 0 0 PF00059;PF00084; Q04786 CHOYP_NEMVEDRAFT_V1G201552.2.6 m.4068 sp HEX_VIBVL 35.714 868 479 21 864 1687 6 838 5.88E-161 515 HEX_VIBVL reviewed Beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) hex Vibrio vulnificus 847 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004563; GO:0006032; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. 0 0 PF03173;PF00728;PF02838; Q3L1C9 CHOYP_LOC100533450.1.1 m.54335 sp STAUH_APLCA 69.231 117 34 2 1 117 346 460 5.88E-35 130 STAUH_APLCA reviewed Double-stranded RNA-binding protein Staufen homolog 0 Aplysia californica (California sea hare) 950 regulation of protein localization [GO:0032880] GO:0003729; GO:0032880; GO:0043005; GO:0043025 0 0 0 PF00035;PF16482; Q3UHD1 CHOYP_LOC100702950.1.4 m.2385 sp BAI1_MOUSE 26.453 654 411 20 19 638 581 1198 5.88E-55 208 BAI1_MOUSE reviewed Brain-specific angiogenesis inhibitor 1 Bai1 Mus musculus (Mouse) 1582 cell surface receptor signaling pathway [GO:0007166]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965] GO:0004930; GO:0005886; GO:0007166; GO:0014069; GO:0016021; GO:0016525; GO:0051965 0 0 0 PF00002;PF16489;PF01825;PF02793;PF00090; Q5UPF8 CHOYP_TVAG_178480.2.2 m.40273 sp YL088_MIMIV 22.56 461 265 8 43 456 83 498 5.88E-11 68.9 YL088_MIMIV reviewed Putative ankyrin repeat protein L88 MIMI_L88 Acanthamoeba polyphaga mimivirus (APMV) 879 0 0 0 0 0 PF12796; Q6AZ60 CHOYP_MD27A.2.2 m.20145 sp EGFL7_RAT 29.851 134 69 6 52 165 85 213 5.88E-08 57 EGFL7_RAT reviewed Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) Egfl7 Cbl20 Megf7 Rattus norvegicus (Rat) 279 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001938; GO:0005509; GO:0005576; GO:0005615; GO:0007155; GO:0031012; GO:0045746 0 0 0 PF07974;PF07645;PF07546; Q8WV28 CHOYP_PHUM_PHUM128460.2.7 m.26204 sp BLNK_HUMAN 29.68 219 116 8 512 714 254 450 5.88E-15 81.6 BLNK_HUMAN reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH SLP65 Homo sapiens (Human) 456 B cell differentiation [GO:0030183]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005622; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0006959; GO:0030183; GO:0035556 0 0 0 PF00017; Q8WV28 CHOYP_PHUM_PHUM128460.3.7 m.27983 sp BLNK_HUMAN 29.68 219 116 8 497 699 254 450 5.88E-15 81.6 BLNK_HUMAN reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH SLP65 Homo sapiens (Human) 456 B cell differentiation [GO:0030183]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005622; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0006959; GO:0030183; GO:0035556 0 0 0 PF00017; Q9ESN6 CHOYP_BRAFLDRAFT_87273.1.3 m.17218 sp TRIM2_MOUSE 25.49 153 97 5 45 192 600 740 5.88E-07 52.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A1L162 CHOYP_BRAFLDRAFT_74793.2.2 m.36140 sp ERIC2_HUMAN 44.565 92 49 2 169 260 64 153 5.89E-13 68.6 ERIC2_HUMAN reviewed Glutamate-rich protein 2 ERICH2 Homo sapiens (Human) 156 0 0 0 0 0 0 B2RYG6 CHOYP_OTUB1.1.1 m.29705 sp OTUB1_RAT 57.143 245 104 1 16 259 26 270 5.89E-100 296 OTUB1_RAT reviewed Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (Ubiquitin-specific-processing protease OTUB1) Otub1 Rattus norvegicus (Rat) 271 adaptive immune response [GO:0002250]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to interleukin-1 [GO:0071347]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; protein K48-linked deubiquitination [GO:0071108] GO:0002250; GO:0004843; GO:0005634; GO:0005737; GO:0006281; GO:0006974; GO:0019784; GO:0043130; GO:0070062; GO:0071108; GO:0071347; GO:1901315; GO:2000780 0 0 0 PF10275; B3EWY9 CHOYP_LOC575161.4.5 m.42590 sp MLP_ACRMI 27.778 1062 619 39 169 1167 387 1363 5.89E-94 342 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O11780 CHOYP_NEMVEDRAFT_V1G957.1.1 m.27284 sp BGH3_PIG 31.356 236 156 6 81 311 139 373 5.89E-26 111 BGH3_PIG reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) (Kerato-epithelin) (RGD-containing collagen-associated protein) (RGD-CAP) TGFBI Sus scrofa (Pig) 683 cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; extracellular matrix organization [GO:0030198] GO:0005578; GO:0005615; GO:0007155; GO:0008283; GO:0030198; GO:0050839; GO:0050840 0 0 0 PF02469; Q14162 CHOYP_MEGF6.16.59 m.24543 sp SREC_HUMAN 31.915 141 81 7 21 161 88 213 5.89E-09 60.5 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q28DE6 CHOYP_LOC578100.2.3 m.17191 sp RSBNL_XENTR 70.968 155 42 1 3 157 492 643 5.89E-73 252 RSBNL_XENTR reviewed Round spermatid basic protein 1-like rsbn1l TEgg039d07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 782 0 GO:0005634 0 0 0 0 Q5RGT6 CHOYP_ANGE2.1.1 m.15705 sp ANGE2_DANRE 37.219 489 261 11 112 575 96 563 5.89E-90 291 ANGE2_DANRE reviewed Protein angel homolog 2 angel2 si:ch211-181h6.2 zgc:153829 Danio rerio (Zebrafish) (Brachydanio rerio) 569 0 0 0 0 0 PF03372; Q60714 CHOYP_LOC100375206.1.1 m.8725 sp S27A1_MOUSE 37.436 195 120 1 41 233 16 210 5.89E-40 148 S27A1_MOUSE reviewed Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.-) (Solute carrier family 27 member 1) Slc27a1 Fatp Fatp1 Mus musculus (Mouse) 646 adiponectin-activated signaling pathway [GO:0033211]; cardiolipin biosynthetic process [GO:0032049]; fatty acid transport [GO:0015908]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylglycerol biosynthetic process [GO:0006655]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; response to cold [GO:0009409]; response to insulin [GO:0032868] GO:0000166; GO:0001579; GO:0001676; GO:0004467; GO:0005743; GO:0005783; GO:0005886; GO:0005901; GO:0006646; GO:0006654; GO:0006655; GO:0006656; GO:0006659; GO:0006661; GO:0009409; GO:0015245; GO:0015908; GO:0015909; GO:0016020; GO:0016021; GO:0031410; GO:0031652; GO:0031957; GO:0032049; GO:0032868; GO:0033211; GO:0042803; GO:0071072; GO:0071902 0 0 0 PF00501;PF13193; Q6DDL7 CHOYP_LOC100367380.1.1 m.14742 sp UN93A_XENLA 35.991 439 269 6 19 446 2 439 5.89E-89 281 UN93A_XENLA reviewed Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) 460 0 GO:0016021 0 0 cd06174; PF05978; Q7L5N7 CHOYP_PCAT2.2.2 m.56644 sp PCAT2_HUMAN 52.165 485 226 5 3 485 25 505 5.89E-166 483 PCAT2_HUMAN reviewed Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) LPCAT2 AGPAT11 AYTL1 Homo sapiens (Human) 544 membrane organization [GO:0061024]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; platelet activating factor biosynthetic process [GO:0006663] GO:0000139; GO:0003841; GO:0005509; GO:0005783; GO:0005789; GO:0005795; GO:0005811; GO:0006663; GO:0016021; GO:0036151; GO:0047144; GO:0047184; GO:0047192; GO:0061024 PATHWAY: Lipid metabolism; phospholipid metabolism. 0 0 PF01553;PF13499; Q8N328 CHOYP_LOC100498109.1.3 m.29965 sp PGBD3_HUMAN 25.329 304 184 9 7 292 313 591 5.89E-13 72.4 PGBD3_HUMAN reviewed PiggyBac transposable element-derived protein 3 PGBD3 Homo sapiens (Human) 593 0 0 0 0 0 PF13843; Q924H5 CHOYP_LOC583093.1.1 m.18950 sp RA51C_MOUSE 52.273 352 159 3 4 347 2 352 5.89E-129 377 RA51C_MOUSE reviewed DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2) Rad51c Rad51l2 Mus musculus (Mouse) 366 DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283]; strand invasion [GO:0042148]; telomere maintenance via recombination [GO:0000722] GO:0000150; GO:0000400; GO:0000722; GO:0000724; GO:0000730; GO:0000794; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005739; GO:0006281; GO:0006310; GO:0007066; GO:0007131; GO:0007141; GO:0007283; GO:0008094; GO:0008821; GO:0010212; GO:0010971; GO:0033063; GO:0033065; GO:0042148; GO:0048471; GO:0048476 0 0 0 PF08423; Q9BQQ7 CHOYP_LOC100374693.1.1 m.62043 sp RTP3_HUMAN 26.087 161 102 6 93 241 7 162 5.89E-10 60.8 RTP3_HUMAN reviewed Receptor-transporting protein 3 (3CxxC-type zinc finger protein 3) (Transmembrane protein 7) RTP3 TMEM7 Z3CXXC3 Homo sapiens (Human) 232 detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; protein insertion into membrane [GO:0051205]; protein targeting to membrane [GO:0006612] GO:0001580; GO:0005737; GO:0006612; GO:0016021; GO:0031849; GO:0051205 0 0 0 PF13695; D3Z8D9 CHOYP_LOC100313650.1.1 m.1671 sp MD2L2_RAT 44.33 194 107 1 15 208 13 205 5.90E-57 182 MD2L2_RAT reviewed Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) Mad2l2 Rattus norvegicus (Rat) 211 "actin filament organization [GO:0007015]; cell division [GO:0051301]; DNA damage response, signal transduction resulting in transcription [GO:0042772]; double-strand break repair [GO:0006302]; mitotic nuclear division [GO:0007067]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell growth [GO:0001558]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001558; GO:0005634; GO:0005680; GO:0005737; GO:0005819; GO:0006302; GO:0006351; GO:0007015; GO:0007067; GO:0008432; GO:0010719; GO:0010944; GO:0016035; GO:0033138; GO:0042177; GO:0042772; GO:0043433; GO:0045893; GO:0051301; GO:0090090; GO:1904667; GO:2000048; GO:2000678 0 0 0 PF02301; O07552 CHOYP_LOC100181607.2.2 m.55285 sp NHAX_BACSU 26.25 160 102 4 73 216 7 166 5.90E-09 56.6 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O35309 CHOYP_LOC100367414.5.7 m.57926 sp NMI_MOUSE 33.813 139 77 6 165 291 160 295 5.90E-07 54.7 NMI_MOUSE reviewed N-myc-interactor (Nmi) (N-myc and STAT interactor) Nmi Mus musculus (Mouse) 314 interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of innate immune response [GO:0045824]; negative regulation of interferon-alpha biosynthetic process [GO:0045355]; negative regulation of interferon-beta biosynthetic process [GO:0045358]; negative regulation of type I interferon production [GO:0032480]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; transcription from RNA polymerase II promoter [GO:0006366] GO:0003712; GO:0005654; GO:0005737; GO:0006366; GO:0032480; GO:0045355; GO:0045358; GO:0045824; GO:0060333; GO:1902524 0 0 0 PF07334;PF07292; O88843 CHOYP_contig_040342 m.45731 sp CRADD_MOUSE 28.571 126 82 3 1 125 1 119 5.90E-06 47 CRADD_MOUSE reviewed Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) Cradd Raidd Mus musculus (Mouse) 199 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; positive regulation of apoptotic signaling pathway [GO:2001235]" GO:0002020; GO:0005634; GO:0005737; GO:0006915; GO:0006919; GO:0006977; GO:0030674; GO:0070513; GO:0071260; GO:2001235 0 0 0 PF00619;PF00531; P23469 CHOYP_PTPRD.1.3 m.46484 sp PTPRE_HUMAN 30.695 619 384 20 193 781 87 690 5.90E-79 271 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; P41044 CHOYP_CAB32.1.1 m.52444 sp CAB32_DROME 64.626 294 103 1 30 322 15 308 5.90E-134 386 CAB32_DROME reviewed Calbindin-32 Cbp53E cbn CG6702 Drosophila melanogaster (Fruit fly) 310 negative regulation of response to wounding [GO:1903035]; regulation of cytosolic calcium ion concentration [GO:0051480] GO:0005509; GO:0005634; GO:0005829; GO:0051480; GO:0061175; GO:0097467; GO:1903035 0 0 0 PF00036;PF13499; P86854 CHOYP_MRC1.4.4 m.63487 sp PLCL_MYTGA 26.984 126 83 5 41 165 39 156 5.90E-10 58.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q09654 CHOYP_LOC755290.1.4 m.651 sp TRI23_CAEEL 28.846 156 89 8 23 156 118 273 5.90E-07 51.2 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q0E908 CHOYP_CPIPJ_CPIJ000133.2.2 m.47975 sp HIL_DROME 26.181 508 311 13 38 503 333 818 5.90E-43 170 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q502M6 CHOYP_TVAG_123950.25.31 m.54154 sp ANR29_DANRE 39.07 215 130 1 4 218 31 244 5.90E-46 157 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5ZIJ9 CHOYP_BRAFLDRAFT_120990.11.18 m.51970 sp MIB2_CHICK 43.939 66 30 1 341 399 9 74 5.90E-09 62.8 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q61263 CHOYP_LOC100716750.1.1 m.16732 sp SOAT1_MOUSE 44.28 542 282 9 7 536 5 538 5.90E-157 461 SOAT1_MOUSE reviewed Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) Soat1 Acact Mus musculus (Mouse) 540 cholesterol efflux [GO:0033344]; cholesterol esterification [GO:0034435]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol storage [GO:0010878]; macrophage derived foam cell differentiation [GO:0010742]; positive regulation of amyloid precursor protein biosynthetic process [GO:0042986]; very-low-density lipoprotein particle assembly [GO:0034379] GO:0000062; GO:0004772; GO:0005783; GO:0005789; GO:0008203; GO:0010742; GO:0010878; GO:0015485; GO:0016020; GO:0016021; GO:0033344; GO:0034379; GO:0034435; GO:0034736; GO:0042632; GO:0042986 0 0 0 PF03062; Q86I06 CHOYP_NEK2.3.3 m.58492 sp NEK3_DICDI 38.065 155 92 2 4 155 102 255 5.90E-28 119 NEK3_DICDI reviewed Probable serine/threonine-protein kinase nek3 (EC 2.7.11.1) (Never in mitosis protein A-related protein kinase 3) (NimA-related protein kinase 3) nek3 DDB_G0275241 Dictyostelium discoideum (Slime mold) 1123 0 GO:0004674; GO:0005524 0 0 0 PF00069; Q922M7 CHOYP_BRAFLDRAFT_99073.1.1 m.18282 sp ASHWN_MOUSE 38.554 83 51 0 18 100 17 99 5.90E-09 58.2 ASHWN_MOUSE reviewed Ashwin 0 Mus musculus (Mouse) 232 embryonic morphogenesis [GO:0048598] GO:0048598; GO:0072669 0 0 0 PF15323; Q96DM1 CHOYP_LOC100661020.3.5 m.24722 sp PGBD4_HUMAN 27.312 465 305 13 98 540 103 556 5.90E-42 162 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9NUA8 CHOYP_LOC100197217.1.2 m.19401 sp ZBT40_HUMAN 30.894 123 72 3 11 128 4 118 5.90E-06 53.1 ZBT40_HUMAN reviewed Zinc finger and BTB domain-containing protein 40 ZBTB40 KIAA0478 Homo sapiens (Human) 1239 "bone mineralization [GO:0030282]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0006974; GO:0030282; GO:0046872 0 0 0 PF00651; Q9Z2W9 CHOYP_LOC100533312.1.1 m.13900 sp GRIA3_MOUSE 41.791 67 39 0 1 67 789 855 5.90E-12 65.1 GRIA3_MOUSE reviewed "Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3)" Gria3 Glur3 Kiaa4184 Mus musculus (Mouse) 888 response to fungicide [GO:0060992] GO:0004971; GO:0005234; GO:0005654; GO:0005886; GO:0014069; GO:0016020; GO:0030054; GO:0032279; GO:0032281; GO:0043083; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0045211; GO:0060992 0 0 0 PF01094;PF00060;PF10613; A0A0R4I9Y1 CHOYP_NEMVEDRAFT_V1G239505.2.2 m.66987 sp R213B_DANRE 26.957 115 70 2 1 106 4567 4676 5.91E-08 52.4 R213B_DANRE reviewed E3 ubiquitin-protein ligase rnf213-beta (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-B) (Mysterin-beta) (RING finger protein 213-B) (RING finger protein 213-beta) rnf213b Danio rerio (Zebrafish) (Brachydanio rerio) 5061 protein ubiquitination [GO:0016567] GO:0005829; GO:0008270; GO:0016567; GO:0016787; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A4IGK4 CHOYP_RBM10.2.2 m.59955 sp RBM5_XENTR 41.041 826 403 22 92 861 41 838 5.91E-172 522 RBM5_XENTR reviewed RNA-binding protein 5 (RNA-binding motif protein 5) rbm5 TGas113j08.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 838 "positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal complex assembly [GO:0000245]" GO:0000166; GO:0000245; GO:0000381; GO:0003729; GO:0005634; GO:0005681; GO:0008270; GO:0043065 0 0 0 PF01585;PF00076;PF00641; A6NGD5 CHOYP_AAEL_AAEL009187.1.1 m.25730 sp ZSA5C_HUMAN 32.174 115 72 4 622 734 348 458 5.91E-10 65.9 ZSA5C_HUMAN reviewed Putative zinc finger and SCAN domain-containing protein 5C (Zinc finger and SCAN domain-containing protein 5C pseudogene) ZSCAN5CP ZSCAN5C Homo sapiens (Human) 496 "transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF02023;PF00096; D3YXG0 CHOYP_LOC100374680.1.1 m.3880 sp HMCN1_MOUSE 28.721 766 494 22 38 788 1557 2285 5.91E-66 246 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; H3ZPL1 CHOYP_LOC100119008.1.1 m.43229 sp ARAT1_THELN 28.535 389 255 9 3 388 45 413 5.91E-41 152 ARAT1_THELN reviewed Aromatic-amino-acid aminotransferase 1 (ARAT-I) (AROAT) (EC 2.6.1.57) OCC_04335 Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) 417 biosynthetic process [GO:0009058] GO:0008793; GO:0009058; GO:0030170; GO:0080130 0 0 0 PF00155; O01393 CHOYP_LOC100533356.6.6 m.63561 sp UNC9_CAEEL 39.216 357 206 4 1 357 36 381 5.91E-96 294 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O08550 CHOYP_MLL.1.1 m.33426 sp KMT2B_MOUSE 62.903 310 110 3 3476 3782 2406 2713 5.91E-121 435 KMT2B_MOUSE reviewed Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) Kmt2b Mll2 Trx2 Wbp7 Mus musculus (Mouse) 2713 "gene silencing [GO:0016458]; histone H3-K4 methylation [GO:0051568]; histone H3-K4 trimethylation [GO:0080182]; histone lysine methylation [GO:0034968]; memory [GO:0007613]; oocyte differentiation [GO:0009994]; ovarian follicle development [GO:0001541]; ovulation [GO:0030728]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001541; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007613; GO:0008270; GO:0009994; GO:0016458; GO:0030728; GO:0034968; GO:0035097; GO:0042800; GO:0051568; GO:0051569; GO:0080182 0 0 0 PF05965;PF05964;PF00628;PF00856;PF02008; O15990 CHOYP_KARG.4.11 m.5401 sp KARG_LIOJA 62.5 144 53 1 1 143 1 144 5.91E-60 191 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O70277 CHOYP_BRAFLDRAFT_87285.3.8 m.50783 sp TRIM3_RAT 28.244 131 86 4 72 195 614 743 5.91E-08 56.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P00765 CHOYP_PLMN.1.11 m.5524 sp TRYP_ASTAS 40.586 239 131 4 55 286 1 235 5.91E-55 181 TRYP_ASTAS reviewed Trypsin-1 (EC 3.4.21.4) (Trypsin I) 0 Astacus astacus (Noble crayfish) (Astacus fluviatilis) 237 digestion [GO:0007586] GO:0004252; GO:0005615; GO:0007586; GO:0046872 0 0 cd00190; PF00089; P07882 CHOYP_CEL.2.3 m.27351 sp CEL_RAT 28.653 349 197 13 1 334 215 526 5.91E-20 94.7 CEL_RAT reviewed Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) Cel Rattus norvegicus (Rat) 612 lipid catabolic process [GO:0016042]; modulation of synaptic transmission [GO:0050804]; neuron cell-cell adhesion [GO:0007158]; synapse assembly [GO:0007416] GO:0004622; GO:0004771; GO:0004806; GO:0004872; GO:0005615; GO:0005737; GO:0005791; GO:0005794; GO:0005829; GO:0005887; GO:0007158; GO:0007416; GO:0009986; GO:0016042; GO:0032403; GO:0042043; GO:0042588; GO:0043208; GO:0043231; GO:0043234; GO:0045121; GO:0045202; GO:0050253; GO:0050804; GO:0052689 0 0 0 PF00135; P16157 CHOYP_TVAG_168010.37.45 m.59937 sp ANK1_HUMAN 26.579 380 222 7 234 563 139 511 5.91E-31 132 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22031 CHOYP_BRAFLDRAFT_109205.5.5 m.36008 sp LEG_HELCR 40 90 51 1 35 121 13 102 5.91E-18 76.6 LEG_HELCR reviewed D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 105 0 GO:0005737; GO:0030246 0 0 0 PF02140; P43689 CHOYP_TPM.19.19 m.66623 sp TPM2_BIOGL 72.024 168 47 0 1 168 1 168 5.91E-76 232 TPM2_BIOGL reviewed Tropomyosin-2 (Tropomyosin II) (BgTMII) (TMII) 0 Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) 284 0 0 0 0 0 PF00261; P62084 CHOYP_LOC101050758.1.1 m.40538 sp RS7_DANRE 81.395 86 15 1 33 117 1 86 5.91E-42 139 RS7_DANRE reviewed 40S ribosomal protein S7 rps7 zgc:73216 Danio rerio (Zebrafish) (Brachydanio rerio) 194 chordate embryonic development [GO:0043009]; hemopoiesis [GO:0030097]; regulation of cell cycle [GO:0051726]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0003735; GO:0006364; GO:0006412; GO:0022627; GO:0030097; GO:0030686; GO:0032040; GO:0042274; GO:0043009; GO:0051726 0 0 0 PF01251; P84039 CHOYP_BRAFLDRAFT_85509.1.1 m.7000 sp ENPP5_RAT 43.358 399 213 6 23 417 12 401 5.91E-109 333 ENPP5_RAT reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-) Enpp5 Rattus norvegicus (Rat) 477 cell communication [GO:0007154]; metabolic process [GO:0008152] GO:0005886; GO:0007154; GO:0008152; GO:0016021; GO:0016787; GO:0046872 0 0 0 PF01663; P93009 CHOYP_LOC100743919.1.1 m.19201 sp CUTA_ARATH 57.143 49 21 0 50 98 82 130 5.91E-13 64.7 CUTA_ARATH reviewed "Protein CutA, chloroplastic (Copper-binding protein CutA) (AtCUTA)" CUTA At2g33740 T1B8.5 Arabidopsis thaliana (Mouse-ear cress) 182 response to metal ion [GO:0010038] GO:0005507; GO:0009507; GO:0010038; GO:0031972 0 0 0 PF03091; Q05438 CHOYP_BMR1A.1.1 m.62775 sp BMR1B_CHICK 52.51 478 209 8 35 509 30 492 5.91E-178 513 BMR1B_CHICK reviewed Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (Activin receptor-like kinase 6) (ALK-6) (RPK-1) (Serine/threonine-protein kinase receptor R6) (SKR6) BMPR1B Gallus gallus (Chicken) 502 BMP signaling pathway [GO:0030509]; cellular response to growth factor stimulus [GO:0071363]; chondrocyte development [GO:0002063]; endochondral bone morphogenesis [GO:0060350]; negative regulation of chondrocyte proliferation [GO:1902731]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; proteoglycan biosynthetic process [GO:0030166] GO:0002063; GO:0004675; GO:0004702; GO:0005524; GO:0005886; GO:0030166; GO:0030509; GO:0032332; GO:0044214; GO:0046872; GO:0060350; GO:0061036; GO:0071363; GO:1902731 0 0 0 PF01064;PF07714;PF08515; Q06852 CHOYP_CPIPJ_CPIJ004536.2.3 m.52643 sp SLAP1_CLOTH 28.648 562 332 22 38 586 1386 1891 5.91E-09 65.1 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q13115 CHOYP_DUSP4.1.1 m.11073 sp DUS4_HUMAN 37.596 391 221 8 1 376 10 392 5.91E-73 235 DUS4_HUMAN reviewed Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) DUSP4 MKP2 VH2 Homo sapiens (Human) 394 dephosphorylation [GO:0016311]; endoderm formation [GO:0001706]; inactivation of MAPK activity [GO:0000188]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; peptidyl-threonine dephosphorylation [GO:0035970]; peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0000188; GO:0001706; GO:0004725; GO:0005634; GO:0005654; GO:0008330; GO:0016311; GO:0016791; GO:0017017; GO:0035335; GO:0035970; GO:0070373; GO:1990439 0 0 0 PF00782;PF00581; Q26474 CHOYP_LOC662036.1.1 m.592 sp LACH_SCHAM 29.932 147 81 7 49 188 35 166 5.91E-07 53.9 LACH_SCHAM reviewed Lachesin LAC Schistocerca americana (American grasshopper) 349 cell adhesion [GO:0007155]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005886; GO:0007155; GO:0007169; GO:0031225 0 0 0 PF07679; Q5R6S0 CHOYP_LOC100375565.1.1 m.55803 sp ABHGA_PONAB 42.959 561 276 6 28 549 1 556 5.91E-168 491 ABHGA_PONAB reviewed Protein ABHD16A (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 16A) (Abhydrolase domain-containing protein 16A) (HLA-B-associated transcript 5) ABHD16A BAT5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 558 0 GO:0016021; GO:0016787 0 0 0 PF00561; Q6QAP7 CHOYP_RS17.10.11 m.58729 sp RS17_PIG 83.594 128 20 1 1 128 1 127 5.91E-74 219 RS17_PIG reviewed 40S ribosomal protein S17 RPS17 Sus scrofa (Pig) 135 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00833; Q6ZRF8 CHOYP_LOC100370588.15.19 m.60881 sp RN207_HUMAN 23.98 196 128 8 5 194 114 294 5.91E-10 65.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q86YS6 CHOYP_LOC100366735.1.1 m.52023 sp RAB43_HUMAN 63.5 200 71 1 11 210 13 210 5.91E-93 273 RAB43_HUMAN reviewed Ras-related protein Rab-43 (Ras-related protein Rab-41) RAB43 RAB41 Homo sapiens (Human) 212 "Golgi organization [GO:0007030]; phagosome maturation [GO:0090382]; retrograde transport, plasma membrane to Golgi [GO:0035526]; small GTPase mediated signal transduction [GO:0007264]; toxin transport [GO:1901998]; virion assembly [GO:0019068]" GO:0003924; GO:0005525; GO:0005768; GO:0005794; GO:0007030; GO:0007264; GO:0019068; GO:0030670; GO:0032588; GO:0035526; GO:0045335; GO:0070062; GO:0090382; GO:1901998 0 0 0 PF00071; Q8AWC7 CHOYP_FUT11.1.1 m.14979 sp FUT11_CHICK 44.844 417 205 9 41 442 87 493 5.91E-112 342 FUT11_CHICK reviewed "Alpha-(1,3)-fucosyltransferase 11 (EC 2.4.1.-) (Fucosyltransferase XI) (Fuc-TXI) (FucT-XI) (Galactoside 3-L-fucosyltransferase 11) (Fucosyltransferase 11)" FUT11 Gallus gallus (Chicken) 505 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0032580; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q8K0U4 CHOYP_HS12A.21.33 m.58427 sp HS12A_MOUSE 31.329 632 371 16 862 1434 46 673 5.91E-81 285 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q91WM2 CHOYP_LOC100183583.2.2 m.42824 sp CECR5_MOUSE 58.416 101 42 0 6 106 229 329 5.91E-38 135 CECR5_MOUSE reviewed Cat eye syndrome critical region protein 5 homolog Cecr5 Mus musculus (Mouse) 419 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q92193 CHOYP_FAF1.1.1 m.35623 sp ACT_CRAVI 84.516 155 6 1 2 156 56 192 5.91E-90 265 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96DT7 CHOYP_BACH1.16.17 m.53583 sp ZBT10_HUMAN 29.268 123 68 3 11 122 346 460 5.91E-07 56.2 ZBT10_HUMAN reviewed Zinc finger and BTB domain-containing protein 10 (Zinc finger protein RIN ZF) ZBTB10 RINZF RINZFC Homo sapiens (Human) 871 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005654; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651; O43301 CHOYP_HS12B.4.14 m.31611 sp HS12A_HUMAN 28.499 593 363 13 43 586 57 637 5.92E-70 242 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O43557 CHOYP_TNFSF10.1.1 m.59325 sp TNF14_HUMAN 32.414 145 82 8 186 326 108 240 5.92E-12 67.8 TNF14_HUMAN reviewed "Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]" TNFSF14 HVEML LIGHT UNQ391/PRO726 Homo sapiens (Human) 240 apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of T cell chemotaxis [GO:0010820]; release of cytoplasmic sequestered NF-kappaB [GO:0008588]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0005102; GO:0005615; GO:0005737; GO:0005886; GO:0006915; GO:0006955; GO:0007165; GO:0008588; GO:0010820; GO:0016021; GO:0031295; GO:0033209; GO:0042098; GO:0042110; GO:0043027; GO:0043029; GO:0045663; GO:0071260; GO:1901741 0 0 0 PF00229; O70277 CHOYP_BRAFLDRAFT_255103.6.18 m.32780 sp TRIM3_RAT 21.224 245 180 4 22 255 488 730 5.92E-08 56.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P42346 CHOYP_MTOR.1.2 m.15750 sp MTOR_RAT 77.099 131 30 0 2 132 1882 2012 5.92E-62 209 MTOR_RAT reviewed Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin target protein 1) (RAPT1) Mtor Frap1 Raft1 Rattus norvegicus (Rat) 2549 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; brain development [GO:0007420]; cardiac muscle cell development [GO:0055013]; cardiac muscle contraction [GO:0060048]; cell aging [GO:0007569]; cell growth [GO:0016049]; cell projection organization [GO:0030030]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; DNA repair [GO:0006281]; energy reserve metabolic process [GO:0006112]; germ cell development [GO:0007281]; heart morphogenesis [GO:0003007]; heart valve morphogenesis [GO:0003179]; long-term memory [GO:0007616]; maternal process involved in female pregnancy [GO:0060135]; mRNA stabilization [GO:0048255]; multicellular organism growth [GO:0035264]; negative regulation of autophagy [GO:0010507]; negative regulation of cell size [GO:0045792]; negative regulation of cholangiocyte apoptotic process [GO:1904193]; negative regulation of iodide transmembrane transport [GO:1904213]; negative regulation of macroautophagy [GO:0016242]; negative regulation of muscle atrophy [GO:0014736]; negative regulation of NFAT protein import into nucleus [GO:0051534]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein ubiquitination [GO:0031397]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell death [GO:0010942]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of cholangiocyte proliferation [GO:1904056]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of eating behavior [GO:1904000]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of granulosa cell proliferation [GO:1904197]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron maturation [GO:0014042]; positive regulation of neuron projection development [GO:0010976]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of sensory perception of pain [GO:1904058]; positive regulation of skeletal muscle hypertrophy [GO:1904206]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription from RNA polymerase III promoter [GO:0045945]; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901838]; positive regulation of translation [GO:0045727]; post-embryonic development [GO:0009791]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of brown fat cell differentiation [GO:0090335]; regulation of carbohydrate metabolic process [GO:0006109]; regulation of carbohydrate utilization [GO:0043610]; regulation of fatty acid beta-oxidation [GO:0031998]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of GTPase activity [GO:0043087]; regulation of membrane permeability [GO:0090559]; regulation of myelination [GO:0031641]; regulation of osteoclast differentiation [GO:0045670]; regulation of protein kinase activity [GO:0045859]; regulation of response to food [GO:0032095]; response to amino acid [GO:0043200]; response to cocaine [GO:0042220]; response to insulin [GO:0032868]; response to morphine [GO:0043278]; ruffle organization [GO:0031529]; social behavior [GO:0035176]; spinal cord development [GO:0021510]; TOR signaling [GO:0031929]; visual learning [GO:0008542]; voluntary musculoskeletal movement [GO:0050882]; wound healing [GO:0042060] GO:0000139; GO:0001030; GO:0001031; GO:0001032; GO:0001933; GO:0001938; GO:0003007; GO:0003179; GO:0004674; GO:0005524; GO:0005634; GO:0005741; GO:0005764; GO:0005765; GO:0005789; GO:0005829; GO:0005979; GO:0006109; GO:0006112; GO:0006207; GO:0006281; GO:0006468; GO:0007281; GO:0007420; GO:0007569; GO:0007616; GO:0008542; GO:0009791; GO:0010507; GO:0010592; GO:0010831; GO:0010942; GO:0010976; GO:0014042; GO:0014736; GO:0016049; GO:0016242; GO:0016605; GO:0018105; GO:0018107; GO:0019901; GO:0019904; GO:0021510; GO:0030030; GO:0030425; GO:0030838; GO:0031397; GO:0031529; GO:0031641; GO:0031669; GO:0031929; GO:0031931; GO:0031932; GO:0031998; GO:0032095; GO:0032868; GO:0032991; GO:0035176; GO:0035264; GO:0042060; GO:0042220; GO:0043022; GO:0043087; GO:0043200; GO:0043278; GO:0043610; GO:0045429; GO:0045670; GO:0045727; GO:0045792; GO:0045859; GO:0045945; GO:0046777; GO:0046889; GO:0048255; GO:0048661; GO:0048714; GO:0050731; GO:0050769; GO:0050882; GO:0051496; GO:0051534; GO:0051897; GO:0055013; GO:0060048; GO:0060135; GO:0060252; GO:0060999; GO:0061051; GO:0071456; GO:0090335; GO:0090559; GO:1901216; GO:1901838; GO:1904000; GO:1904056; GO:1904058; GO:1904193; GO:1904197; GO:1904206; GO:1904213 0 0 0 PF11865;PF02259;PF02260;PF08771;PF00454; P62878 CHOYP_RBX1A.1.1 m.63168 sp RBX1_MOUSE 88.785 107 12 0 18 124 2 108 5.92E-69 205 RBX1_MOUSE reviewed "E3 ubiquitin-protein ligase RBX1 (EC 6.3.2.-) (RING finger protein 75) (RING-box protein 1) (Rbx1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed]" Rbx1 Mus musculus (Mouse) 108 DNA repair [GO:0006281]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process [GO:0030163]; protein monoubiquitination [GO:0006513]; protein neddylation [GO:0045116]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0004842; GO:0005680; GO:0005829; GO:0006281; GO:0006511; GO:0006513; GO:0008190; GO:0008270; GO:0016567; GO:0016874; GO:0019005; GO:0019788; GO:0030163; GO:0030891; GO:0031146; GO:0031461; GO:0031462; GO:0031463; GO:0031464; GO:0031465; GO:0031466; GO:0031467; GO:0034450; GO:0042787; GO:0043161; GO:0043224; GO:0045116; GO:0061630; GO:0080008; GO:0097602 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12678; Q28852 CHOYP_contig_042148 m.48444 sp ATP5L_BOVIN 33.333 81 54 0 34 114 23 103 5.92E-07 49.7 ATP5L_BOVIN reviewed "ATP synthase subunit g, mitochondrial (ATPase subunit g)" ATP5L Bos taurus (Bovine) 103 ATP synthesis coupled proton transport [GO:0015986] GO:0000276; GO:0005753; GO:0015078; GO:0015986 0 0 0 PF04718; Q63ZR5 CHOYP_HIAT1.1.1 m.63550 sp RHN2B_XENLA 39.075 389 222 6 1 382 211 591 5.92E-91 293 RHN2B_XENLA reviewed Rhophilin-2-B (GTP-Rho-binding protein 2-B) rhpn2-b Xenopus laevis (African clawed frog) 683 signal transduction [GO:0007165] GO:0007165; GO:0048471 0 0 0 PF03097;PF02185; Q6P9B9 CHOYP_BRAFLDRAFT_124611.1.1 m.34341 sp INT5_HUMAN 30.558 1021 591 26 6 940 21 1009 5.92E-121 396 INT5_HUMAN reviewed Integrator complex subunit 5 (Int5) INTS5 KIAA1698 Homo sapiens (Human) 1019 snRNA processing [GO:0016180]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0005634; GO:0005654; GO:0016020; GO:0016021; GO:0016180; GO:0032039; GO:0042795 0 0 0 PF14838;PF14837; Q6Q311 CHOYP_RS25.3.11 m.11867 sp RS25_SHEEP 75.862 87 21 0 18 104 33 119 5.92E-36 122 RS25_SHEEP reviewed 40S ribosomal protein S25 RPS25 Ovis aries (Sheep) 125 0 GO:0005840 0 0 0 PF03297; Q7RTY7 CHOYP_LOC101155223.1.1 m.53862 sp OVCH1_HUMAN 27.132 129 91 2 30 155 417 545 5.92E-06 50.8 OVCH1_HUMAN reviewed Ovochymase-1 (EC 3.4.21.-) OVCH1 Homo sapiens (Human) 1134 0 GO:0004252; GO:0005576; GO:0046872 0 0 cd00190; PF00431;PF00089; Q7Z5P9 CHOYP_PF13_0210.1.2 m.9255 sp MUC19_HUMAN 34.622 569 285 28 17 530 4420 4956 5.92E-07 56.6 MUC19_HUMAN reviewed Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) 8384 O-glycan processing [GO:0016266] GO:0005796; GO:0016266; GO:0070062 0 0 0 PF08742;PF01826;PF00094; Q8IZ57 CHOYP_BRAFLDRAFT_83581.1.1 m.28264 sp NRSN1_HUMAN 32.609 184 101 7 55 227 24 195 5.92E-19 84.7 NRSN1_HUMAN reviewed Neurensin-1 (Neuro-p24) (Vesicular membrane protein of 24 kDa) (Vesicular membrane protein p24) NRSN1 VMP Homo sapiens (Human) 195 nervous system development [GO:0007399] GO:0007399; GO:0016021; GO:0016023; GO:0030133; GO:0030426; GO:0043005; GO:0043025 0 0 0 0 Q91ZN1 CHOYP_CORO.1.1 m.23174 sp COR1A_RAT 43.662 71 38 1 1 71 349 417 5.92E-10 63.2 COR1A_RAT reviewed Coronin-1A (Coronin-like protein A) (Clipin-A) (Tryptophan aspartate-containing coat protein) (TACO) Coro1a Coro1 Rattus norvegicus (Rat) 461 actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; calcium ion transport [GO:0006816]; cell-substrate adhesion [GO:0031589]; cellular response to interleukin-4 [GO:0071353]; early endosome to recycling endosome transport [GO:0061502]; homeostasis of number of cells within a tissue [GO:0048873]; leukocyte chemotaxis [GO:0030595]; natural killer cell degranulation [GO:0043320]; negative regulation of actin nucleation [GO:0051126]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of vesicle fusion [GO:0031339]; nerve growth factor signaling pathway [GO:0038180]; phagolysosome assembly [GO:0001845]; positive chemotaxis [GO:0050918]; positive regulation of cell migration [GO:0030335]; positive regulation of T cell proliferation [GO:0042102]; regulation of cell shape [GO:0008360]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; uropod organization [GO:0032796] GO:0001772; GO:0001845; GO:0001891; GO:0005769; GO:0005829; GO:0005884; GO:0005911; GO:0006816; GO:0007015; GO:0008360; GO:0015629; GO:0030027; GO:0030036; GO:0030217; GO:0030335; GO:0030424; GO:0030595; GO:0030670; GO:0030864; GO:0031339; GO:0031589; GO:0032796; GO:0038180; GO:0042102; GO:0043029; GO:0043234; GO:0043320; GO:0043524; GO:0044822; GO:0048873; GO:0050918; GO:0051015; GO:0051126; GO:0051279; GO:0061502; GO:0070062; GO:0071353 0 0 0 PF08953;PF08954;PF00400; Q96K76 CHOYP_UBP4.2.2 m.44546 sp UBP47_HUMAN 24.889 225 137 7 431 642 189 394 5.92E-09 63.2 UBP47_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47) USP47 Homo sapiens (Human) 1375 "base-excision repair [GO:0006284]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell growth [GO:0030307]; response to drug [GO:0042493]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0004843; GO:0005634; GO:0005737; GO:0006284; GO:0006511; GO:0006974; GO:0010972; GO:0019005; GO:0030307; GO:0034644; GO:0035520; GO:0042493; GO:0043066; GO:0043154; GO:0045892; GO:0071987; GO:1902230 0 0 0 PF00443; Q9CR58 CHOYP_KMCP1.2.2 m.16595 sp KMCP1_MOUSE 62.5 288 105 2 3 290 5 289 5.92E-134 384 KMCP1_MOUSE reviewed Kidney mitochondrial carrier protein 1 (Solute carrier family 25 member 30) Slc25a30 Kmcp1 Mus musculus (Mouse) 291 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005739; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q9CXW2 CHOYP_LOC100869188.1.1 m.18952 sp RT22_MOUSE 35.743 249 150 4 50 296 67 307 5.92E-40 148 RT22_MOUSE reviewed "28S ribosomal protein S22, mitochondrial (MRP-S22) (S22mt)" Mrps22 Rpms22 Mus musculus (Mouse) 359 0 GO:0003735; GO:0005739; GO:0005763 0 0 0 PF10245; Q9D3P8 CHOYP_BRAFLDRAFT_88556.1.1 m.50506 sp PLRKT_MOUSE 45.638 149 74 3 23 168 1 145 5.92E-38 130 PLRKT_MOUSE reviewed Plasminogen receptor (KT) (Plg-R(KT)) Plgrkt Mus musculus (Mouse) 147 chemotaxis [GO:0006935]; inflammatory response [GO:0006954]; positive regulation of plasminogen activation [GO:0010756] GO:0005739; GO:0005887; GO:0006935; GO:0006954; GO:0010756 0 0 0 PF10166; Q9D7Q1 CHOYP_CHIT1.1.3 m.2916 sp CHIT1_MOUSE 39.35 277 133 8 1 273 219 464 5.92E-47 168 CHIT1_MOUSE reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) Chit1 Mus musculus (Mouse) 464 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0006032; GO:0008061; GO:0008843 0 0 0 PF01607;PF00704; Q9ESN6 CHOYP_LOC100373444.3.79 m.2777 sp TRIM2_MOUSE 27.778 198 131 8 365 557 536 726 5.92E-11 68.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9QY93 CHOYP_LOC100641006.1.1 m.6417 sp DCTP1_MOUSE 50.413 121 60 0 25 145 23 143 5.92E-39 132 DCTP1_MOUSE reviewed dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21-C6) (XTP3-transactivated gene A protein homolog) Dctpp1 Tdrg-TL1 Mus musculus (Mouse) 170 nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside triphosphate catabolic process [GO:0009143]; protein homotetramerization [GO:0051289] GO:0000287; GO:0005829; GO:0009143; GO:0015949; GO:0016462; GO:0032556; GO:0042802; GO:0047429; GO:0047840; GO:0051289 0 0 cd11537; PF12643; Q9R0W9 CHOYP_ACHB3.3.5 m.58276 sp ACHA6_MOUSE 30.4 375 243 6 14 376 10 378 5.92E-60 205 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9UI26 CHOYP_IPO11.1.1 m.10815 sp IPO11_HUMAN 62.722 169 63 0 1 169 1 169 5.92E-72 236 IPO11_HUMAN reviewed Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11) IPO11 RANBP11 Homo sapiens (Human) 975 ribosomal protein import into nucleus [GO:0006610]; transcription factor import into nucleus [GO:0042991] GO:0005635; GO:0005829; GO:0006610; GO:0008565; GO:0042991 0 0 0 PF03810; Q9VCA2 CHOYP_ORCT.4.6 m.55572 sp ORCT_DROME 36.232 276 161 4 1 270 1 267 5.92E-53 183 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9Y345 CHOYP_LOC100375514.3.6 m.39058 sp SC6A5_HUMAN 45.062 162 87 1 2 163 607 766 5.92E-44 160 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; P02710 CHOYP_ACH2.1.1 m.63012 sp ACHA_TETCF 26.027 438 289 10 25 430 26 460 5.93E-46 168 ACHA_TETCF reviewed Acetylcholine receptor subunit alpha CHRNA1 Tetronarce californica (Pacific electric ray) (Torpedo californica) 461 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; Q5F478 CHOYP_TVAG_262090.1.1 m.29944 sp ANR44_CHICK 25 216 140 7 1 215 22 216 5.93E-07 55.1 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5I0X7 CHOYP_TTC32.1.2 m.183 sp TTC32_HUMAN 40.152 132 71 2 11 135 15 145 5.93E-23 90.9 TTC32_HUMAN reviewed Tetratricopeptide repeat protein 32 (TPR repeat protein 32) TTC32 Homo sapiens (Human) 151 0 0 0 0 0 PF00515; Q6JEL2 CHOYP_KLH10.1.1 m.49492 sp KLH10_HUMAN 41.446 567 324 3 22 587 29 588 5.93E-164 483 KLH10_HUMAN reviewed Kelch-like protein 10 KLHL10 Homo sapiens (Human) 608 cell morphogenesis [GO:0000902]; fertilization [GO:0009566]; homeostasis of number of cells within a tissue [GO:0048873]; male genitalia morphogenesis [GO:0048808]; male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]; spermatid development [GO:0007286] GO:0000902; GO:0005737; GO:0007286; GO:0008584; GO:0009566; GO:0016567; GO:0031463; GO:0048808; GO:0048873 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q70E73 CHOYP_ISCW_ISCW014636.1.2 m.28505 sp RAPH1_HUMAN 49.827 289 139 4 237 524 243 526 5.93E-86 301 RAPH1_HUMAN reviewed Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) RAPH1 ALS2CR18 ALS2CR9 KIAA1681 LPD PREL2 RMO1 Homo sapiens (Human) 1250 axon extension [GO:0048675]; signal transduction [GO:0007165] GO:0005737; GO:0005856; GO:0005886; GO:0007165; GO:0030027; GO:0030175; GO:0048675 0 0 0 PF00169;PF00788; Q7Z2W4 CHOYP_LOC100370625.2.3 m.26929 sp ZCCHV_HUMAN 29.197 137 84 5 105 236 82 210 5.93E-11 66.6 ZCCHV_HUMAN reviewed Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) ZC3HAV1 ZC3HDC2 PRO1677 Homo sapiens (Human) 902 cellular response to exogenous dsRNA [GO:0071360]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]; regulation of defense response to virus by host [GO:0050691]; response to virus [GO:0009615]; suppression by virus of host molecular function [GO:0039507] GO:0003950; GO:0005634; GO:0005737; GO:0005764; GO:0005770; GO:0005794; GO:0005913; GO:0009615; GO:0032481; GO:0032727; GO:0032728; GO:0039507; GO:0043123; GO:0044822; GO:0045071; GO:0045087; GO:0046872; GO:0050691; GO:0051607; GO:0061014; GO:0071360; GO:0098641; GO:1900246 0 0 0 PF00644;PF02825; Q924S7 CHOYP_SPRE2.1.1 m.50966 sp SPRE2_MOUSE 41.284 436 219 11 3 430 4 410 5.93E-102 312 SPRE2_MOUSE reviewed "Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)" Spred2 Mus musculus (Mouse) 410 "inactivation of MAPK activity [GO:0000188]; multicellular organism development [GO:0007275]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of protein deacetylation [GO:0090311]" GO:0000188; GO:0005173; GO:0005886; GO:0007275; GO:0010801; GO:0019901; GO:0030291; GO:0030658; GO:0031410; GO:0043517; GO:0090311 0 0 0 PF05210;PF00568; Q92626 CHOYP_KIRREL.1.1 m.7159 sp PXDN_HUMAN 26.667 150 92 3 49 194 343 478 5.93E-09 60.1 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q96GP6 CHOYP_MEGF6.11.59 m.24283 sp SREC2_HUMAN 40.179 112 61 4 1 110 254 361 5.93E-16 76.6 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q99999 CHOYP_BRAFLDRAFT_129875.2.2 m.62310 sp G3ST1_HUMAN 30.662 287 165 10 59 336 64 325 5.93E-26 112 G3ST1_HUMAN reviewed Galactosylceramide sulfotransferase (GalCer sulfotransferase) (EC 2.8.2.11) (3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase) (3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase) (Cerebroside sulfotransferase) GAL3ST1 CST Homo sapiens (Human) 423 galactosylceramide biosynthetic process [GO:0006682]; myelination [GO:0042552]; protein N-linked glycosylation [GO:0006487]; spermatogenesis [GO:0007283] GO:0000139; GO:0001733; GO:0005887; GO:0006487; GO:0006682; GO:0007283; GO:0008146; GO:0016020; GO:0042552 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF06990; Q99M80 CHOYP_PTPRK.9.20 m.13960 sp PTPRT_MOUSE 31.818 550 344 10 231 767 764 1295 5.93E-77 275 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q99MI1 CHOYP_RB6I2.2.2 m.65652 sp RB6I2_MOUSE 39.48 884 456 13 215 1042 127 987 5.93E-155 493 RB6I2_MOUSE reviewed ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (CAZ-associated structural protein 2) (CAST2) (Rab6-interacting protein 2) Erc1 Cast2 Kiaa1081 Rab6ip2 Mus musculus (Mouse) 1120 "I-kappaB phosphorylation [GO:0007252]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000139; GO:0005737; GO:0007252; GO:0008385; GO:0015031; GO:0017137; GO:0030165; GO:0042147; GO:0045202; GO:0048786 0 0 0 PF10174;PF09457; Q9C0D9 CHOYP_BRAFLDRAFT_123523.1.1 m.18771 sp EPT1_HUMAN 48.177 384 187 3 4 383 6 381 5.93E-117 348 EPT1_HUMAN reviewed Ethanolaminephosphotransferase 1 (hEPT1) (EC 2.7.8.1) (Selenoprotein I) (SelI) EPT1 KIAA1724 SELI Homo sapiens (Human) 397 phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of protein targeting to mitochondrion [GO:1903955] GO:0004307; GO:0005789; GO:0006646; GO:0016021; GO:0046872; GO:1903955 PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. 0 0 PF01066; Q9JJG5 CHOYP_LOC100496857.1.1 m.17189 sp SRTD2_MOUSE 28.261 322 138 15 2 247 5 309 5.93E-09 58.9 SRTD2_MOUSE reviewed SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2) Sertad2 Kiaa0127 MNCb-1504 Mus musculus (Mouse) 309 "negative regulation of cell growth [GO:0030308]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005737; GO:0006351; GO:0030308; GO:0045893 0 0 0 PF06031; Q9JJG5 CHOYP_LOC100496857.1.1 m.17190 sp SRTD2_MOUSE 28.261 322 138 15 2 247 5 309 5.93E-09 58.9 SRTD2_MOUSE reviewed SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2) Sertad2 Kiaa0127 MNCb-1504 Mus musculus (Mouse) 309 "negative regulation of cell growth [GO:0030308]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005737; GO:0006351; GO:0030308; GO:0045893 0 0 0 PF06031; Q9QZN3 CHOYP_FBXO8.1.1 m.66085 sp FBX8_MOUSE 60.87 253 94 2 25 273 68 319 5.93E-109 321 FBX8_MOUSE reviewed F-box only protein 8 Fbxo8 Fbx8 Mus musculus (Mouse) 319 regulation of ARF protein signal transduction [GO:0032012]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0005086; GO:0006511; GO:0032012 0 0 0 PF12937;PF01369; A0PQX0 CHOYP_RIV7116_2086.1.1 m.44136 sp PHMT1_MYCUA 26.724 116 85 0 212 327 75 190 5.94E-09 60.1 PHMT1_MYCUA reviewed Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase 1 (EC 2.1.1.-) MUL_2377 Mycobacterium ulcerans (strain Agy99) 271 lipid metabolic process [GO:0006629] GO:0006629; GO:0008168 0 0 0 PF08241; A3RLT6 CHOYP_RSSA.2.10 m.4243 sp RSSA_PINFU 90.476 105 10 0 1 105 1 105 5.94E-57 180 RSSA_PINFU reviewed 40S ribosomal protein SA 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 301 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003735; GO:0006412; GO:0022627 0 0 cd01425; PF16122;PF00318; O15439 CHOYP_MRP4.3.3 m.47438 sp MRP4_HUMAN 41.2 500 268 6 1 500 166 639 5.94E-124 396 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O62640 CHOYP_LOC100647366.1.2 m.27812 sp PIAP_PIG 33.503 197 119 6 153 342 86 277 5.94E-29 118 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P24014 CHOYP_ISCW_ISCW018193.1.1 m.33196 sp SLIT_DROME 26.962 293 147 12 240 488 460 729 5.94E-13 75.9 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P33538 CHOYP_LOC575748.4.4 m.52429 sp DPOM_NEUIN 23.762 202 128 4 433 628 414 595 5.94E-06 53.5 DPOM_NEUIN reviewed Probable DNA polymerase (EC 2.7.7.7) 0 Neurospora intermedia 969 DNA replication [GO:0006260] GO:0000166; GO:0003677; GO:0003887; GO:0005739; GO:0006260; GO:0008408 0 0 0 PF03175; P53459 CHOYP_ACT6.1.2 m.20329 sp ACT6_DIPDE 54.223 367 168 0 24 390 6 372 5.94E-149 429 ACT6_DIPDE reviewed Actin-6 (Fragment) ACT6 Diphyllobothrium dendriticum (Tapeworm) 373 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P83425 CHOYP_C1QL3.3.5 m.53243 sp HIP_MYTED 32.52 123 71 4 71 186 69 186 5.94E-08 53.9 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q0KHY3 CHOYP_LOC100890161.2.3 m.36684 sp MESH_DROME 26.371 1058 613 41 23 973 181 1179 5.94E-71 265 MESH_DROME reviewed Protein mesh mesh CG31004 Drosophila melanogaster (Fruit fly) 1454 cell-matrix adhesion [GO:0007160]; multicellular organism development [GO:0007275]; smooth septate junction assembly [GO:0090528] GO:0005920; GO:0007160; GO:0007275; GO:0016021; GO:0016327; GO:0090528 0 0 0 PF03782;PF06119;PF00084;PF00094; Q5EA98 CHOYP_LOC100880308.1.1 m.6158 sp MFAP1_BOVIN 60.82 439 159 6 9 447 12 437 5.94E-138 405 MFAP1_BOVIN reviewed Microfibrillar-associated protein 1 MFAP1 Bos taurus (Bovine) 439 0 GO:0001527; GO:0044822 0 0 0 PF06991; Q5GH73 CHOYP_AAEL_AAEL002820.1.1 m.51981 sp XKR6_HUMAN 26.937 271 172 9 81 332 244 507 5.94E-28 122 XKR6_HUMAN reviewed XK-related protein 6 XKR6 C8orf21 C8orf5 C8orf7 XRG6 Homo sapiens (Human) 641 0 GO:0016020; GO:0016021 0 0 0 PF09815; Q5R9C1 CHOYP_AGAP_AGAP012010.1.2 m.6115 sp F263_PONAB 65.138 109 36 2 11 117 26 134 5.94E-44 152 F263_PONAB reviewed "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]" PFKFB3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 514 "fructose 2,6-bisphosphate metabolic process [GO:0006003]; fructose metabolic process [GO:0006000]" GO:0003873; GO:0004331; GO:0005524; GO:0006000; GO:0006003 0 0 cd07067; PF01591;PF00300; Q5RDJ2 CHOYP_LOC100769984.1.2 m.35547 sp ZMYM2_PONAB 27.027 148 90 6 3 132 1212 1359 5.94E-07 54.3 ZMYM2_PONAB reviewed Zinc finger MYM-type protein 2 (Zinc finger protein 198) ZMYM2 ZNF198 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1377 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF12012;PF06467; Q5THR3 CHOYP_BRAFLDRAFT_77829.1.1 m.66885 sp EFCB6_HUMAN 33.6 125 77 2 17 141 121 239 5.94E-15 74.3 EFCB6_HUMAN reviewed EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) 1501 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q5W8I7 CHOYP_VGL2B.1.1 m.25006 sp VGL2B_DANRE 34.298 484 302 6 5 485 69 539 5.94E-97 308 VGL2B_DANRE reviewed Vesicular glutamate transporter 2.2 (Solute carrier family 17 member 6-A) (Vesicular glutamate transporter 2-B) slc17a6a slc17a6l vglut2.2 vglut2b Danio rerio (Zebrafish) (Brachydanio rerio) 587 L-glutamate transmembrane transport [GO:0089711]; neurotransmitter transport [GO:0006836]; sodium ion transport [GO:0006814] GO:0005313; GO:0006814; GO:0006836; GO:0015293; GO:0016021; GO:0030054; GO:0030672; GO:0043005; GO:0089711 0 0 cd06174; PF07690; Q8K0U4 CHOYP_LOC100533316.2.2 m.47773 sp HS12A_MOUSE 34.489 519 284 10 6 470 158 674 5.94E-100 317 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K386 CHOYP_RAB15.1.1 m.24536 sp RAB15_MOUSE 52.083 192 91 1 20 210 1 192 5.94E-67 208 RAB15_MOUSE reviewed Ras-related protein Rab-15 Rab15 Mus musculus (Mouse) 212 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0015031 0 0 0 PF00071; Q92982 CHOYP_contig_041571 m.47529 sp NINJ1_HUMAN 40.984 61 36 0 68 128 39 99 5.94E-10 59.3 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q96RW7 CHOYP_LOC589644.2.3 m.21781 sp HMCN1_HUMAN 25.74 777 488 30 3 752 639 1353 5.94E-46 185 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96RW7 CHOYP_MDGA2.2.2 m.66368 sp HMCN1_HUMAN 23.901 523 328 23 91 569 2063 2559 5.94E-20 98.6 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99489 CHOYP_OXDD.4.4 m.51986 sp OXDD_HUMAN 44.3 307 160 6 28 328 1 302 5.94E-79 247 OXDD_HUMAN reviewed D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Homo sapiens (Human) 341 aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; D-amino acid catabolic process [GO:0019478]; glyoxylate metabolic process [GO:0046487]; grooming behavior [GO:0007625]; hormone metabolic process [GO:0042445]; insemination [GO:0007320] GO:0005102; GO:0005777; GO:0005782; GO:0006531; GO:0006533; GO:0007320; GO:0007625; GO:0008445; GO:0019478; GO:0042445; GO:0046487; GO:0048037; GO:0071949 0 0 0 PF01266; Q9ESN6 CHOYP_contig_028465 m.32406 sp TRIM2_MOUSE 24.528 159 109 4 164 313 547 703 5.94E-06 51.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H4E5 CHOYP_RHOJ.2.2 m.25292 sp RHOJ_HUMAN 39.512 205 109 4 16 220 20 209 5.94E-50 165 RHOJ_HUMAN reviewed Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein) RHOJ ARHJ RASL7B RHOI TCL Homo sapiens (Human) 214 actin cytoskeleton organization [GO:0030036]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; Rho protein signal transduction [GO:0007266] GO:0003924; GO:0005525; GO:0005829; GO:0005886; GO:0007266; GO:0008360; GO:0030036; GO:0051056; GO:0061299; GO:0070062 0 0 0 PF00071; Q9P225 CHOYP_BRAFLDRAFT_72754.1.1 m.23281 sp DYH2_HUMAN 68.182 220 70 0 1 220 2582 2801 5.94E-107 343 DYH2_HUMAN reviewed "Dynein heavy chain 2, axonemal (Axonemal beta dynein heavy chain 2) (Ciliary dynein heavy chain 2) (Dynein heavy chain domain-containing protein 3)" DNAH2 DNAHC2 DNHD3 KIAA1503 Homo sapiens (Human) 4427 cilium or flagellum-dependent cell motility [GO:0001539]; microtubule-based movement [GO:0007018] GO:0001539; GO:0003777; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0007018; GO:0016887 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q9Y394 CHOYP_NEMVEDRAFT_V1G99227.1.1 m.25421 sp DHRS7_HUMAN 43.667 300 166 3 25 322 28 326 5.94E-80 249 DHRS7_HUMAN reviewed Dehydrogenase/reductase SDR family member 7 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4) (Short chain dehydrogenase/reductase family 34C member 1) DHRS7 DHRS7A RETSDR4 SDR34C1 CGI-86 UNQ285/PRO3448 Homo sapiens (Human) 339 0 GO:0016020; GO:0016491 0 0 0 PF00106; B3MFV7 CHOYP_LOC100367484.1.1 m.57281 sp LPHN_DROAN 36.607 112 67 2 97 208 16 123 5.95E-14 73.9 LPHN_DROAN reviewed Latrophilin Cirl Cirl GF12369 Drosophila ananassae (Fruit fly) 1714 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021; GO:0030246 0 0 0 PF16489;PF02140;PF01825; P02553 CHOYP_TBA.1.6 m.12217 sp TBA_LYTPI 97.26 146 4 0 1 146 16 161 5.95E-104 296 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P32004 CHOYP_L1CAM.1.2 m.34870 sp L1CAM_HUMAN 23.861 461 293 19 46 478 22 452 5.95E-18 91.3 L1CAM_HUMAN reviewed Neural cell adhesion molecule L1 (N-CAM-L1) (NCAM-L1) (CD antigen CD171) L1CAM CAML1 MIC5 Homo sapiens (Human) 1257 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; chemotaxis [GO:0006935]; leukocyte migration [GO:0050900]; nervous system development [GO:0007399]; positive regulation of axon extension [GO:0045773] GO:0005886; GO:0005925; GO:0006935; GO:0007155; GO:0007399; GO:0007411; GO:0009986; GO:0016021; GO:0044295; GO:0045773; GO:0050900 0 0 0 PF13882;PF00041;PF07679; P52187 CHOYP_LOC100871940.1.1 m.7479 sp KCJ12_MOUSE 37.297 370 221 5 26 390 35 398 5.95E-85 268 KCJ12_MOUSE reviewed "ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Potassium channel, inwardly rectifying subfamily J member 12)" Kcnj12 Irk2 Mus musculus (Mouse) 427 potassium ion import [GO:0010107]; potassium ion transport [GO:0006813]; protein homotetramerization [GO:0051289] GO:0005242; GO:0005887; GO:0006813; GO:0010107; GO:0031224; GO:0051289 0 0 0 PF01007;PF08466; Q02058 CHOYP_BRAFLDRAFT_118645.1.1 m.30629 sp DIM6_STRCO 25.786 159 107 4 78 235 9 157 5.95E-12 67 DIM6_STRCO reviewed Actinorhodin polyketide dimerase (EC 1.-.-.-) (actI ORF6) actVB SCO5092 SCBAC28G1.18 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 177 antibiotic biosynthetic process [GO:0017000] GO:0010181; GO:0017000; GO:0042602 PATHWAY: Antibiotic biosynthesis; actinorhodin biosynthesis. 0 0 PF01613; Q29RU9 CHOYP_BRAFLDRAFT_68491.1.1 m.26328 sp SOX_BOVIN 35.099 151 95 2 14 164 4 151 5.95E-18 82.8 SOX_BOVIN reviewed Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) PIPOX Bos taurus (Bovine) 392 L-lysine catabolic process to acetyl-CoA via L-pipecolate [GO:0033514]; tetrahydrofolate metabolic process [GO:0046653] GO:0005777; GO:0008115; GO:0033514; GO:0046653; GO:0050031 0 0 0 PF01266; Q69BJ8 CHOYP_LOC100742152.2.2 m.11485 sp UCRI_LAGLA 56.552 145 62 1 2 146 129 272 5.95E-58 184 UCRI_LAGLA reviewed "Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 11 (Complex III subunit IX) (Ubiquinol-cytochrome c reductase 8 kDa protein)]" UQCRFS1 Lagothrix lagotricha (Brown woolly monkey) (Humboldt's woolly monkey) 274 0 GO:0005743; GO:0008121; GO:0016021; GO:0046872; GO:0051537; GO:0070469 0 0 0 PF00355;PF09165;PF02921; Q6UW60 CHOYP_LOC100650142.1.1 m.63481 sp PCSK4_HUMAN 41.296 494 267 11 85 565 94 577 5.95E-111 352 PCSK4_HUMAN reviewed Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4) PCSK4 PC4 UNQ2757/PRO6496 Homo sapiens (Human) 755 acrosome reaction [GO:0007340]; binding of sperm to zona pellucida [GO:0007339]; fertilization [GO:0009566]; protein processing [GO:0016485]; reproductive process [GO:0022414]; sperm capacitation [GO:0048240] GO:0001669; GO:0002080; GO:0004252; GO:0005615; GO:0007339; GO:0007340; GO:0009566; GO:0016021; GO:0016485; GO:0022414; GO:0048240 0 0 0 PF01483;PF00082;PF16470; Q80Y75 CHOYP_LOC100377412.1.1 m.41404 sp DJB13_MOUSE 62.975 316 116 1 29 344 1 315 5.95E-146 417 DJB13_MOUSE reviewed DnaJ homolog subfamily B member 13 (Testis and spermatogenesis cell-related protein 6) (Testis spermatocyte apoptosis-related gene 6 protein) (Testis spermatogenesis apoptosis-related gene 3 protein) (Testis spermatogenesis apoptosis-related gene 6 protein) Dnajb13 Tsarg Tsarg3 Tsarg6 Mus musculus (Mouse) 316 protein folding [GO:0006457] GO:0005737; GO:0005930; GO:0006457; GO:0031514; GO:0036126 0 0 cd06257; PF00226;PF01556; Q86VX9 CHOYP_BRAFLDRAFT_234513.1.1 m.9581 sp MON1A_HUMAN 52.482 423 199 2 98 520 135 555 5.95E-162 474 MON1A_HUMAN reviewed Vacuolar fusion protein MON1 homolog A MON1A SAND1 Homo sapiens (Human) 555 protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192] GO:0009306; GO:0012505; GO:0016192 0 0 0 PF03164; Q8C3Q9 CHOYP_CASP9.1.2 m.49458 sp CASP9_MOUSE 29.087 471 275 16 1 450 1 433 5.95E-39 149 CASP9_MOUSE reviewed Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] Casp9 Mch6 Mus musculus (Mouse) 454 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aging [GO:0007568]; apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; glial cell apoptotic process [GO:0034349]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of response to DNA damage stimulus [GO:2001020]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to UV [GO:0009411]; signal transduction in response to DNA damage [GO:0042770] GO:0004197; GO:0005634; GO:0005739; GO:0005829; GO:0006915; GO:0006919; GO:0006974; GO:0007568; GO:0008233; GO:0008630; GO:0009411; GO:0017124; GO:0019901; GO:0032025; GO:0032355; GO:0032496; GO:0034349; GO:0034644; GO:0042770; GO:0043293; GO:0043525; GO:0046677; GO:0070059; GO:0071549; GO:0097153; GO:2001020 0 0 0 PF00619; Q99K82 CHOYP_SMOX.1.2 m.3830 sp SMOX_MOUSE 37.594 532 273 9 14 487 19 549 5.95E-108 334 SMOX_MOUSE reviewed Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1) Smox Smo Mus musculus (Mouse) 555 polyamine catabolic process [GO:0006598]; spermine catabolic process [GO:0046208] GO:0005634; GO:0005737; GO:0006598; GO:0046208; GO:0046592; GO:0052894; GO:0052895; GO:0052901 PATHWAY: Amine and polyamine degradation; spermine degradation. 0 0 PF01593; Q9UKP5 CHOYP_LOC100897824.1.1 m.54366 sp ATS6_HUMAN 24.67 531 344 24 23 523 43 547 5.95E-19 95.1 ATS6_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-) ADAMTS6 Homo sapiens (Human) 1117 aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976] GO:0003279; GO:0004222; GO:0005578; GO:0008237; GO:0008270; GO:0035904; GO:0060976 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; A6NFD8 CHOYP_LOC100313631.1.1 m.43807 sp HELT_HUMAN 46.667 120 59 1 14 133 13 127 5.96E-34 125 HELT_HUMAN reviewed Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor) HELT Homo sapiens (Human) 242 "central nervous system development [GO:0007417]; GABAergic neuron differentiation in basal ganglia [GO:0021858]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; post-embryonic development [GO:0009791]; suckling behavior [GO:0001967]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0001078; GO:0001967; GO:0005634; GO:0005667; GO:0006351; GO:0007417; GO:0009791; GO:0010259; GO:0021858; GO:0035264; GO:0045944 0 0 0 PF07527;PF00010; E9PVX6 CHOYP_DICPUDRAFT_74702.1.2 m.311 sp KI67_MOUSE 33.696 92 60 1 157 248 7 97 5.96E-06 53.5 KI67_MOUSE reviewed Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67 homolog) (Antigen KI-67 homolog) (Antigen Ki67 homolog) Mki67 Mus musculus (Mouse) 3177 cell proliferation [GO:0008283]; cellular response to heat [GO:0034605]; cholangiocyte proliferation [GO:1990705]; DNA metabolic process [GO:0006259]; hepatocyte proliferation [GO:0072574]; hyaluronan metabolic process [GO:0030212]; meiotic nuclear division [GO:0007126]; organ regeneration [GO:0031100]; response to organic cyclic compound [GO:0014070] GO:0000775; GO:0000793; GO:0005634; GO:0005730; GO:0005737; GO:0006259; GO:0007126; GO:0008022; GO:0008283; GO:0014070; GO:0016020; GO:0030212; GO:0031100; GO:0034605; GO:0044822; GO:0072574; GO:1990705 0 0 0 PF00498;PF08065;PF15276; O70277 CHOYP_LOC100374342.15.19 m.60500 sp TRIM3_RAT 23.664 262 161 11 309 554 506 744 5.96E-08 59.3 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P00178 CHOYP_BRAFLDRAFT_116025.1.2 m.37393 sp CP2B4_RABIT 30.684 453 296 11 29 470 21 466 5.96E-58 202 CP2B4_RABIT reviewed Cytochrome P450 2B4 (EC 1.14.14.1) (CYPIIB4) (Cytochrome P450 isozyme 2) (Cytochrome P450 LM2) (Cytochrome P450 type B0) (Cytochrome P450 type B1) CYP2B4 Oryctolagus cuniculus (Rabbit) 491 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P10394 CHOYP_LOC100370477.2.2 m.16367 sp POL4_DROME 28.231 294 206 3 9 297 896 1189 5.96E-33 137 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P11029 CHOYP_ACAC.2.2 m.58115 sp ACAC_CHICK 78.571 140 30 0 1 140 1783 1922 5.96E-72 238 ACAC_CHICK reviewed Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACAC Gallus gallus (Chicken) 2324 "fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of biological quality [GO:0065008]; regulation of gene expression, epigenetic [GO:0040029]; response to carbohydrate [GO:0009743]; response to fatty acid [GO:0070542]; response to thyroid hormone [GO:0097066]; transport [GO:0006810]" GO:0003989; GO:0004075; GO:0005102; GO:0005524; GO:0005623; GO:0005737; GO:0006633; GO:0006810; GO:0009374; GO:0009743; GO:0010628; GO:0032810; GO:0040029; GO:0045893; GO:0046872; GO:0046966; GO:0050692; GO:0065008; GO:0070542; GO:0097066; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; P22288 CHOYP_GCH1.1.2 m.19567 sp GCH1_RAT 80.108 186 30 1 76 261 62 240 5.96E-109 317 GCH1_RAT reviewed GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) Gch1 Gch Rattus norvegicus (Rat) 241 "7,8-dihydroneopterin 3'-triphosphate biosynthetic process [GO:0035998]; dihydrobiopterin metabolic process [GO:0051066]; dopamine biosynthetic process [GO:0042416]; negative regulation of blood pressure [GO:0045776]; neuromuscular process controlling posture [GO:0050884]; positive regulation of nitric-oxide synthase activity [GO:0051000]; protein complex assembly [GO:0006461]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; regulation of lung blood pressure [GO:0014916]; regulation of removal of superoxide radicals [GO:2000121]; response to interferon-gamma [GO:0034341]; response to lipopolysaccharide [GO:0032496]; response to pain [GO:0048265]; response to tumor necrosis factor [GO:0034612]; tetrahydrobiopterin biosynthetic process [GO:0006729]; tetrahydrofolate biosynthetic process [GO:0046654]; vasodilation [GO:0042311]" GO:0003934; GO:0005509; GO:0005525; GO:0005654; GO:0005737; GO:0005829; GO:0006461; GO:0006729; GO:0008270; GO:0014916; GO:0030742; GO:0031369; GO:0031410; GO:0031965; GO:0032496; GO:0034341; GO:0034612; GO:0035998; GO:0042311; GO:0042416; GO:0043234; GO:0045776; GO:0046654; GO:0048265; GO:0050662; GO:0050884; GO:0051000; GO:0051066; GO:0051260; GO:0051291; GO:2000121 "PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. {ECO:0000305|PubMed:2557335}." 0 0 PF01227; P42325 CHOYP_NCAH.5.5 m.62855 sp NCAH_DROME 59.016 183 72 1 1 180 1 183 5.96E-76 228 NCAH_DROME reviewed Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) 190 0 GO:0005509 0 0 0 PF00036;PF13499; P62257 CHOYP_CPIPJ_CPIJ015105.1.1 m.31438 sp UBE2H_MOUSE 86.339 183 24 1 85 266 1 183 5.96E-108 312 UBE2H_MOUSE reviewed Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UBCH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H) Ube2h Mus musculus (Mouse) 183 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936] GO:0004842; GO:0005524; GO:0005737; GO:0031625; GO:0043161; GO:0061630; GO:0061631; GO:0070936; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; P98092 CHOYP_BRAFLDRAFT_80311.3.3 m.30251 sp HMCT_BOMMO 35.366 164 90 4 162 325 948 1095 5.96E-18 92 HMCT_BOMMO reviewed Hemocytin (Humoral lectin) 0 Bombyx mori (Silk moth) 3133 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF08742;PF00754;PF01826;PF00094; Q04861 CHOYP_IKBZ.1.1 m.23083 sp NFKB1_CHICK 30.677 251 137 7 729 977 524 739 5.96E-22 106 NFKB1_CHICK reviewed Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Gallus gallus (Chicken) 983 cellular response to dsRNA [GO:0071359]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to peptide hormone stimulus [GO:0071375]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 biosynthetic process [GO:0045083]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cytokine [GO:0034097]; response to muscle stretch [GO:0035994] GO:0000122; GO:0000977; GO:0000980; GO:0000981; GO:0001205; GO:0001227; GO:0003682; GO:0005654; GO:0005739; GO:0005829; GO:0006954; GO:0007249; GO:0010956; GO:0033256; GO:0034097; GO:0035994; GO:0038061; GO:0045083; GO:0045087; GO:0045944; GO:0050728; GO:0051059; GO:0071222; GO:0071260; GO:0071316; GO:0071347; GO:0071354; GO:0071359; GO:0071375; GO:0090263; GO:1900127; GO:2000630 0 0 0 PF12796;PF00531;PF16179;PF00554; Q66K08 CHOYP_BRAFLDRAFT_88565.2.2 m.48459 sp CILP1_MOUSE 23.8 958 604 29 171 1083 137 1013 5.96E-71 261 CILP1_MOUSE reviewed Cartilage intermediate layer protein 1 (CILP-1) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] Cilp Mus musculus (Mouse) 1184 negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569] GO:0005578; GO:0005615; GO:0031012; GO:0043569; GO:0070062 0 0 0 PF13330;PF00090; Q6R7B2 CHOYP_DPOL.1.1 m.30091 sp Y001_OSHVF 100 148 0 0 1 148 1 148 5.96E-107 303 Y001_OSHVF reviewed Uncharacterized protein ORF1 ORF1 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 148 0 0 0 0 0 0 Q6R7B2 CHOYP_OSHV1_GP060.1.1 m.28285 sp Y001_OSHVF 100 148 0 0 1 148 1 148 5.96E-107 303 Y001_OSHVF reviewed Uncharacterized protein ORF1 ORF1 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 148 0 0 0 0 0 0 Q6R7B2 CHOYP_Y003.1.1 m.31013 sp Y001_OSHVF 100 148 0 0 1 148 1 148 5.96E-107 303 Y001_OSHVF reviewed Uncharacterized protein ORF1 ORF1 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 148 0 0 0 0 0 0 Q6ZRF8 CHOYP_LOC100373444.34.79 m.32924 sp RN207_HUMAN 24.88 209 134 9 16 218 103 294 5.96E-11 68.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q80X72 CHOYP_LOAG_02782.1.1 m.25400 sp LRC15_MOUSE 27.493 371 228 15 10 368 65 406 5.96E-09 61.6 LRC15_MOUSE reviewed Leucine-rich repeat-containing protein 15 Lrrc15 Mus musculus (Mouse) 579 cytokine-mediated signaling pathway [GO:0019221]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813] GO:0001968; GO:0004860; GO:0005518; GO:0005737; GO:0006469; GO:0016021; GO:0019221; GO:0030335; GO:0043236; GO:0046426; GO:0046813; GO:0070062; GO:0090005 0 0 0 PF13855; Q8INB9 CHOYP_AKT1.1.2 m.23291 sp AKT1_DROME 81.224 245 46 0 1 245 323 567 5.96E-151 437 AKT1_DROME reviewed RAC serine/threonine-protein kinase (DAkt) (DRAC-PK) (Dakt1) (EC 2.7.11.1) (Akt) (Protein kinase B) (PKB) Akt1 CG4006 Drosophila melanogaster (Fruit fly) 611 "apoptotic process [GO:0006915]; chitin-based embryonic cuticle biosynthetic process [GO:0008362]; circadian rhythm [GO:0007623]; dendrite regeneration [GO:0031104]; epithelial cell migration, open tracheal system [GO:0007427]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; lipid metabolic process [GO:0006629]; lipid storage [GO:0019915]; long term synaptic depression [GO:0060292]; multicellular organism growth [GO:0035264]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron death [GO:1901215]; negative regulation of peptide hormone secretion [GO:0090278]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cell growth [GO:0030307]; positive regulation of cell size [GO:0045793]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of organ growth [GO:0046622]; protein phosphorylation [GO:0006468]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of dendrite development [GO:0050773]; regulation of glucose metabolic process [GO:0010906]; regulation of hemocyte proliferation [GO:0035206]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein import into nucleus [GO:0042306]; response to oxidative stress [GO:0006979]; somatic muscle development [GO:0007525]" GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0006629; GO:0006915; GO:0006979; GO:0007424; GO:0007427; GO:0007520; GO:0007525; GO:0007623; GO:0008286; GO:0008360; GO:0008361; GO:0008362; GO:0009986; GO:0010906; GO:0018105; GO:0019915; GO:0030307; GO:0031104; GO:0035091; GO:0035206; GO:0035264; GO:0035556; GO:0040014; GO:0040018; GO:0042306; GO:0043025; GO:0043066; GO:0045793; GO:0045886; GO:0046620; GO:0046622; GO:0048477; GO:0048680; GO:0050773; GO:0060292; GO:0090278; GO:1901215 0 0 0 PF00169;PF00069;PF00433; Q9UM22 CHOYP_LOC100329078.1.3 m.26927 sp EPDR1_HUMAN 28.497 193 129 5 30 217 22 210 5.96E-26 103 EPDR1_HUMAN reviewed Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; A5PLK6 CHOYP_LOC100376370.1.2 m.49261 sp RGSL_HUMAN 21.583 278 170 6 1 253 725 979 5.97E-13 74.3 RGSL_HUMAN reviewed Regulator of G-protein signaling protein-like RGSL1 RGSL RGSL2 Homo sapiens (Human) 1076 0 GO:0005096; GO:0005737; GO:0005886; GO:0016021 0 0 0 PF00615; B0WC46 CHOYP_BRAFLDRAFT_82927.1.1 m.9227 sp TRET1_CULQU 40.315 444 258 5 37 473 57 500 5.97E-106 328 TRET1_CULQU reviewed Facilitated trehalose transporter Tret1 Tret1 CPIJ004516 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) 517 trehalose transport [GO:0015771] GO:0005886; GO:0015574; GO:0015771; GO:0016021 0 0 cd06174; PF00083; P34147 CHOYP_LOC100367936.2.2 m.49545 sp RACA_DICDI 37.037 297 163 6 1 288 221 502 5.97E-53 184 RACA_DICDI reviewed Rho-related protein racA racA DDB_G0286555 Dictyostelium discoideum (Slime mold) 598 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0019901 0 0 0 PF00651;PF00071; Q5HZH2 CHOYP_LOC100010388.1.1 m.18793 sp TSR3_MOUSE 53.275 229 102 2 37 263 39 264 5.97E-84 259 TSR3_MOUSE reviewed Ribosome biogenesis protein TSR3 homolog Tsr3 Mus musculus (Mouse) 323 maturation of SSU-rRNA [GO:0030490] GO:0030490 0 0 0 PF04034;PF04068; Q61847 CHOYP_MEP1B.1.4 m.4612 sp MEP1B_MOUSE 27.604 384 227 19 40 401 75 429 5.97E-24 107 MEP1B_MOUSE reviewed Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) Mep1b Mep-1b Mus musculus (Mouse) 704 inflammatory response [GO:0006954]; toxin transport [GO:1901998] GO:0004222; GO:0005576; GO:0005886; GO:0006954; GO:0008270; GO:0016020; GO:0016021; GO:1901998 0 0 cd06263; PF01400;PF00008;PF00629; Q6IQ22 CHOYP_DVIR_GJ12112.2.3 m.25711 sp RAB12_HUMAN 34.135 208 113 8 38 235 21 214 5.97E-26 104 RAB12_HUMAN reviewed Ras-related protein Rab-12 RAB12 Homo sapiens (Human) 244 autophagy [GO:0006914]; cellular protein catabolic process [GO:0044257]; endosome to lysosome transport [GO:0008333]; positive regulation of macroautophagy [GO:0016239]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0005525; GO:0005764; GO:0005765; GO:0005776; GO:0006914; GO:0007264; GO:0008333; GO:0015031; GO:0016239; GO:0019003; GO:0031410; GO:0044257; GO:0055038 0 0 0 PF00071; Q6ZHE5 CHOYP_NEMVEDRAFT_V1G92762.1.1 m.1253 sp DCYD1_ORYSJ 42.898 352 190 7 3 348 54 400 5.97E-89 277 DCYD1_ORYSJ reviewed "Putative D-cysteine desulfhydrase 1, mitochondrial (EC 4.4.1.15) (OsD-CDes1) (D-CDes1)" Os02g0773300 LOC_Os02g53330 OJ1611_C08.26 OsJ_08555 Oryza sativa subsp. japonica (Rice) 426 0 GO:0005737; GO:0005739; GO:0019148; GO:0030170 0 0 0 PF00291; Q80ZE5 CHOYP_PAQR8.1.2 m.7723 sp MPRB_MOUSE 36.07 341 195 7 4 332 24 353 5.97E-58 193 MPRB_MOUSE reviewed Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ receptor family member VIII) Paqr8 Mprb Mus musculus (Mouse) 354 multicellular organism development [GO:0007275]; oogenesis [GO:0048477]; response to steroid hormone [GO:0048545] GO:0003707; GO:0005496; GO:0005886; GO:0007275; GO:0016021; GO:0048477; GO:0048545 0 0 0 PF03006; Q8TDB6 CHOYP_LOC100060632.2.3 m.34023 sp DTX3L_HUMAN 48.416 221 104 5 631 844 522 739 5.97E-57 212 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q96MM6 CHOYP_HS12A.16.33 m.50931 sp HS12B_HUMAN 33.333 186 60 7 10 195 102 223 5.97E-19 87.8 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9H8W5 CHOYP_BRAFLDRAFT_82867.3.6 m.34026 sp TRI45_HUMAN 24.085 328 195 12 1 284 12 329 5.97E-14 78.2 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9NY12 CHOYP_GAR1.1.2 m.9449 sp GAR1_HUMAN 71.429 105 28 1 73 175 62 166 5.97E-49 162 GAR1_HUMAN reviewed H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1) GAR1 NOLA1 Homo sapiens (Human) 217 rRNA pseudouridine synthesis [GO:0031118]; telomere maintenance via telomerase [GO:0007004] GO:0000784; GO:0005261; GO:0005634; GO:0005654; GO:0005697; GO:0005730; GO:0007004; GO:0031118; GO:0031429; GO:0034513; GO:0044822; GO:0070034; GO:0072589; GO:0090661 0 0 0 PF04410; Q9WVL2 CHOYP_MONBRDRAFT_9339.2.2 m.65190 sp STAT2_MOUSE 44.681 94 52 0 275 368 757 850 5.97E-06 53.5 STAT2_MOUSE reviewed Signal transducer and activator of transcription 2 Stat2 Mus musculus (Mouse) 923 "defense response to virus [GO:0051607]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; transcription, DNA-templated [GO:0006351]; type I interferon signaling pathway [GO:0060337]; xenophagy [GO:0098792]" GO:0001932; GO:0002230; GO:0003677; GO:0003700; GO:0004871; GO:0005634; GO:0005737; GO:0005886; GO:0006351; GO:0042802; GO:0051607; GO:0060337; GO:0090140; GO:0098779; GO:0098792 0 0 0 PF00017;PF12188;PF01017;PF02864;PF02865; O94759 CHOYP_LOC100560953.1.1 m.23222 sp TRPM2_HUMAN 22.5 200 127 5 75 251 166 360 5.98E-07 53.5 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; Q24157 CHOYP_BRN.1.1 m.35403 sp BRN_DROME 32.432 296 184 7 72 355 26 317 5.98E-44 157 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q5F362 CHOYP_LOC100646416.1.1 m.66230 sp CC50A_CHICK 54.335 346 130 7 26 358 34 364 5.98E-112 334 CC50A_CHICK reviewed Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A) TMEM30A CDC50A RCJMB04_32j24 Gallus gallus (Chicken) 372 phospholipid transport [GO:0015914] GO:0005794; GO:0015914; GO:0016021; GO:0016324; GO:0030658 0 0 0 PF03381; Q5RCS8 CHOYP_VATD.2.2 m.64245 sp VATD_PONAB 76.113 247 58 1 21 267 1 246 5.98E-134 381 VATD_PONAB reviewed V-type proton ATPase subunit D (V-ATPase subunit D) (Vacuolar proton pump subunit D) ATP6V1D Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 247 cilium assembly [GO:0042384]; protein localization to cilium [GO:0061512]; proton transport [GO:0015992] GO:0005765; GO:0005813; GO:0005929; GO:0015992; GO:0033176; GO:0042384; GO:0042626; GO:0061512; GO:0070062 0 0 0 PF01813; Q6TGY8 CHOYP_EMC2.2.2 m.21018 sp EMC2_DANRE 50.185 271 132 2 2 270 23 292 5.98E-94 281 EMC2_DANRE reviewed ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35) emc2 ttc35 zgc:86891 Danio rerio (Zebrafish) (Brachydanio rerio) 297 0 GO:0005634; GO:0005737; GO:0005783; GO:0072546 0 0 0 0 Q78WZ7 CHOYP_RPA43.1.1 m.7914 sp RPA43_MOUSE 41.538 130 68 3 30 151 55 184 5.98E-22 95.9 RPA43_MOUSE reviewed DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein) Twistnb Mus musculus (Mouse) 330 transcription from RNA polymerase I promoter [GO:0006360] GO:0003899; GO:0005634; GO:0005730; GO:0005736; GO:0006360; GO:0015630 0 0 0 PF03876; Q95M12 CHOYP_LOC100182585.1.2 m.2597 sp LGMN_BOVIN 46.667 435 219 7 4 435 5 429 5.98E-131 389 LGMN_BOVIN reviewed "Legumain (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1)" LGMN PRSC1 Bos taurus (Bovine) 433 negative regulation of ERBB signaling pathway [GO:1901185]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; receptor catabolic process [GO:0032801]; renal system process [GO:0003014]; vacuolar protein processing [GO:0006624] GO:0003014; GO:0004197; GO:0005764; GO:0006508; GO:0006624; GO:0032801; GO:0051603; GO:1901185 0 0 0 PF01650; Q9QYW3 CHOYP_PHOCN.1.1 m.40660 sp PHOCN_RAT 82.301 226 37 2 19 242 1 225 5.98E-141 397 PHOCN_RAT reviewed MOB-like protein phocein (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Phocein) (Preimplantation protein 3) Mob4 Mob3 Mobkl1 Phocn Prei3 Rattus norvegicus (Rat) 225 membrane budding [GO:0006900] GO:0005737; GO:0005794; GO:0005829; GO:0006900; GO:0016020; GO:0019900; GO:0032580; GO:0043025; GO:0043197; GO:0046872; GO:0048471 0 0 0 PF03637; E7FAM5 CHOYP_LOC100374741.83.83 m.66460 sp LIN41_DANRE 22.846 499 312 17 47 523 234 681 5.99E-11 68.9 LIN41_DANRE reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Danio rerio (Zebrafish) (Brachydanio rerio) 824 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; P09481 CHOYP_ACHB.2.3 m.10968 sp ACHA3_CHICK 29.787 329 212 6 10 333 7 321 5.99E-43 160 ACHA3_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Gallus gallus (Chicken) 496 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; P18433 CHOYP_PTPRE.12.19 m.42505 sp PTPRA_HUMAN 30.496 705 447 21 389 1061 98 791 5.99E-84 293 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P53683 CHOYP_LOC100367481.1.1 m.30872 sp CDPKJ_ORYSJ 33.333 141 91 3 35 175 394 531 5.99E-13 70.9 CDPKJ_ORYSJ reviewed Calcium-dependent protein kinase 19 (OsCDPK19) (OsCPK19) (EC 2.7.11.1) (Calcium-dependent protein kinase isoform 2) (OsCDPK2) (OsCPK2) CPK19 CPK2 Os07g0515100 LOC_Os07g33110 P0048D08.112 Oryza sativa subsp. japonica (Rice) 533 abscisic acid-activated signaling pathway [GO:0009738]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0009738; GO:0009931; GO:0016020; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; P83088 CHOYP_TRIADDRAFT_26518.1.1 m.16475 sp FUCTC_DROME 28.521 284 168 6 101 359 121 394 5.99E-28 117 FUCTC_DROME reviewed "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) 425 protein glycosylation [GO:0006486] GO:0006486; GO:0008417; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; P86854 CHOYP_YBOXH.2.4 m.3352 sp PLCL_MYTGA 30.081 123 78 3 29 147 30 148 5.99E-16 74.3 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P91621 CHOYP_SIF2.1.1 m.24068 sp SIF1_DROME 42.723 213 121 1 5 216 1432 1644 5.99E-48 184 SIF1_DROME reviewed "Protein still life, isoform SIF type 1" sif CG34418 Drosophila melanogaster (Fruit fly) 2072 actin cytoskeleton organization [GO:0030036]; intracellular signal transduction [GO:0035556]; positive regulation of filopodium assembly [GO:0051491]; regulation of axonogenesis [GO:0050770]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synapse structure or activity [GO:0050803] GO:0005057; GO:0005622; GO:0030036; GO:0030054; GO:0030676; GO:0035023; GO:0035556; GO:0043087; GO:0045202; GO:0050770; GO:0050803; GO:0051491 0 0 0 PF00169;PF02196;PF00621; Q06852 CHOYP_contig_016897 m.19870 sp SLAP1_CLOTH 59.406 101 26 8 82 167 1916 2016 5.99E-06 52 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q1PRL4 CHOYP_TRIM8.1.1 m.60178 sp LIN41_CHICK 23.868 243 131 8 6 197 198 437 5.99E-08 56.6 LIN41_CHICK reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) 876 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q2QUN2 CHOYP_LOC100198324.5.6 m.63861 sp LAC24_ORYSJ 26.834 559 310 19 105 612 47 557 5.99E-39 155 LAC24_ORYSJ reviewed Laccase-24 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 24) (Diphenol oxidase 24) (Urishiol oxidase 24) LAC24 Os12g0258700 LOC_Os12g15680 OsJ_016843 OsJ_17624 Oryza sativa subsp. japonica (Rice) 579 lignin catabolic process [GO:0046274] GO:0005507; GO:0016722; GO:0046274; GO:0048046; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q2VLG6 CHOYP_BRAFLDRAFT_120140.1.1 m.50410 sp C163A_CANLF 44.361 133 66 5 1 128 235 364 5.99E-22 105 C163A_CANLF reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis lupus familiaris (Dog) (Canis familiaris) 1133 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q5F359 CHOYP_BRAFLDRAFT_234234.1.2 m.3110 sp TPPC5_CHICK 59.669 181 73 0 168 348 3 183 5.99E-81 247 TPPC5_CHICK reviewed Trafficking protein particle complex subunit 5 TRAPPC5 RCJMB04_33f11 Gallus gallus (Chicken) 188 vesicle-mediated transport [GO:0016192] GO:0005783; GO:0005794; GO:0016192 0 0 cd14943; PF04051; Q5XGG3 CHOYP_LOC100377646.1.1 m.29198 sp PIHD2_XENTR 32.53 332 199 9 12 340 10 319 5.99E-50 172 PIHD2_XENTR reviewed PIH1 domain-containing protein 2 pih1d2 TNeu089n07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 321 0 0 0 0 0 PF08190; Q76KB1 CHOYP_HS2ST.1.1 m.35792 sp HS2ST_CHICK 52.137 351 156 3 26 374 14 354 5.99E-135 392 HS2ST_CHICK reviewed Heparan sulfate 2-O-sulfotransferase 1 (cHS2ST) (EC 2.8.2.-) HS2ST1 HS2ST Gallus gallus (Chicken) 356 0 GO:0000139; GO:0008146; GO:0016021 0 0 0 PF03567; Q7NBF8 CHOYP_LOC585963.2.2 m.37122 sp HMW2_MYCGA 22.677 1173 702 52 8100 9174 124 1189 5.99E-35 153 HMW2_MYCGA reviewed Cytadherence high molecular weight protein 2 (Cytadherence accessory protein 2) hlp2 hmw2 MYCGA3210 MGA_1203 Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2)) 1931 "cytoadherence to microvasculature, mediated by symbiont protein [GO:0020035]; pathogenesis [GO:0009405]" GO:0009405; GO:0020035 0 0 0 0 Q8LGG8 CHOYP_LOC100185549.3.6 m.43515 sp USPAL_ARATH 28.169 142 89 4 21 150 19 159 5.99E-14 68.6 USPAL_ARATH reviewed Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) 175 response to stress [GO:0006950] GO:0005886; GO:0006950; GO:0016208 0 0 0 PF00582; Q96EY1 CHOYP_DNAJA3.1.1 m.15518 sp DNJA3_HUMAN 60 55 22 0 37 91 94 148 5.99E-16 77 DNJA3_HUMAN reviewed "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (hTid-1) (Hepatocellular carcinoma-associated antigen 57) (Tumorous imaginal discs protein Tid56 homolog)" DNAJA3 HCA57 TID1 Homo sapiens (Human) 480 activation-induced cell death of T cells [GO:0006924]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell aging [GO:0007569]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of programmed cell death [GO:0043069]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuromuscular junction development [GO:0007528]; positive regulation of apoptotic process [GO:0043065]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; response to heat [GO:0009408]; response to interferon-gamma [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] GO:0000122; GO:0005133; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006264; GO:0006457; GO:0006469; GO:0006919; GO:0006924; GO:0007005; GO:0007264; GO:0007528; GO:0007569; GO:0008134; GO:0008285; GO:0009408; GO:0019897; GO:0019901; GO:0030054; GO:0030695; GO:0031398; GO:0031594; GO:0032088; GO:0033077; GO:0034341; GO:0042102; GO:0042645; GO:0043065; GO:0043066; GO:0043069; GO:0043124; GO:0043154; GO:0043231; GO:0045211; GO:0046872; GO:0050821; GO:0051059; GO:0060336; GO:0071340 0 0 cd06257; PF00226;PF01556;PF00684; Q9H2G9 CHOYP_BLZF1.1.1 m.60556 sp GO45_HUMAN 35.517 290 167 7 133 404 113 400 5.99E-41 152 GO45_HUMAN reviewed Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor) BLZF1 JEM1 Homo sapiens (Human) 400 cell proliferation [GO:0008283]; Golgi organization [GO:0007030]; Golgi to plasma membrane protein transport [GO:0043001]; regulation of cell growth [GO:0001558]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0001558; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005796; GO:0006357; GO:0007030; GO:0008283; GO:0016192; GO:0019899; GO:0031625; GO:0043001 0 0 0 PF08227; Q9R0M0 CHOYP_FAT2.1.2 m.25518 sp CELR2_MOUSE 30.531 226 139 11 17 228 326 547 5.99E-18 86.3 CELR2_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Flamingo homolog) Celsr2 Mus musculus (Mouse) 2920 "cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0042384]; cilium movement [GO:0003341]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of transcription, DNA-templated [GO:0006355]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]" GO:0001764; GO:0003341; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0016021; GO:0016055; GO:0021591; GO:0021999; GO:0032880; GO:0033326; GO:0042384 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; A1L2I9 CHOYP_LOC100559294.1.1 m.8325 sp T214B_XENLA 31.884 621 373 13 27 626 25 616 6.00E-98 318 T214B_XENLA reviewed Transmembrane protein 214-B tmem214-b Xenopus laevis (African clawed frog) 679 apoptotic process [GO:0006915] GO:0005789; GO:0006915; GO:0016021 0 0 0 PF10151; O57683 CHOYP_SF3B1.3.3 m.50570 sp SF3B1_XENLA 49.495 198 86 6 2 195 4 191 6.00E-47 167 SF3B1_XENLA reviewed Splicing factor 3B subunit 1 (146 kDa nuclear protein) (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) sf3b1 Xenopus laevis (African clawed frog) 1307 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0008380 0 0 0 PF08920; O75445 CHOYP_LOC100558451.1.1 m.58708 sp USH2A_HUMAN 30.671 313 135 10 431 664 575 884 6.00E-32 140 USH2A_HUMAN reviewed Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF02210;PF00055; P02552 CHOYP_AAEL_AAEL013229.1.2 m.30362 sp TBA1_CHICK 83.117 77 3 1 1 77 263 329 6.00E-41 142 TBA1_CHICK reviewed Tubulin alpha-1 chain [Cleaved into: Detyrosinated tubulin alpha-1 chain] (Fragment) 0 Gallus gallus (Chicken) 412 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P50226 CHOYP_LOC100369433.1.1 m.59390 sp ST1A2_HUMAN 30.072 276 169 8 34 294 26 292 6.00E-38 139 ST1A2_HUMAN reviewed Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2) SULT1A2 STP2 Homo sapiens (Human) 295 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine biosynthetic process [GO:0009309]; catecholamine metabolic process [GO:0006584]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005829; GO:0006584; GO:0006805; GO:0008146; GO:0008202; GO:0009309; GO:0018958; GO:0047894; GO:0050427; GO:0051923 0 0 0 PF00685; Q08509 CHOYP_LOC657378.1.1 m.14648 sp EPS8_MOUSE 37.176 347 185 9 296 637 266 584 6.00E-56 211 EPS8_MOUSE reviewed Epidermal growth factor receptor kinase substrate 8 Eps8 Mus musculus (Mouse) 821 actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360] GO:0003779; GO:0005903; GO:0005938; GO:0008344; GO:0008360; GO:0010458; GO:0014069; GO:0016601; GO:0017146; GO:0030054; GO:0030426; GO:0030832; GO:0031532; GO:0031982; GO:0032420; GO:0032587; GO:0035591; GO:0036336; GO:0045202; GO:0048149; GO:0048365; GO:0051016; GO:0051017; GO:0051764; GO:0070062; GO:0070358 0 0 0 PF08416;PF00018; Q28DE7 CHOYP_BRAFLDRAFT_89663.2.2 m.43008 sp KLD10_XENTR 23.006 326 207 11 21 308 17 336 6.00E-19 92.4 KLD10_XENTR reviewed Kelch domain-containing protein 10 klhdc10 TEgg142i20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 411 0 GO:0005634; GO:0005737 0 0 0 PF01344; Q6NZ21 CHOYP_LOC100182897.1.1 m.7227 sp RNFT1_DANRE 46.667 45 24 0 311 355 356 400 6.00E-06 51.6 RNFT1_DANRE reviewed RING finger and transmembrane domain-containing protein 1 rnft1 zgc:77306 Danio rerio (Zebrafish) (Brachydanio rerio) 419 0 GO:0008270; GO:0016021 0 0 0 PF13639; Q7T076 CHOYP_LSM11.1.1 m.616 sp LSM11_XENLA 37.634 186 101 2 22 207 13 183 6.00E-25 106 LSM11_XENLA reviewed U7 snRNA-associated Sm-like protein LSm11 lsm11 Xenopus laevis (African clawed frog) 291 mRNA processing [GO:0006397] GO:0003723; GO:0005634; GO:0006397; GO:0030529 0 0 0 0 Q868Z9 CHOYP_PHUM_PHUM547410.1.1 m.10964 sp PPN_DROME 36.184 304 181 5 118 421 1612 1902 6.00E-55 200 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q86UP9 CHOYP_BRAFLDRAFT_57176.5.5 m.54727 sp LHPL3_HUMAN 42.661 218 124 1 8 225 20 236 6.00E-59 190 LHPL3_HUMAN reviewed Lipoma HMGIC fusion partner-like 3 protein LHFPL3 LHFPL4 Homo sapiens (Human) 236 0 GO:0016021 0 0 0 PF10242; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.19.34 m.44579 sp VWDE_HUMAN 23.888 607 358 26 50 603 53 608 6.00E-21 103 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q9ESN6 CHOYP_BRAFLDRAFT_102380.4.11 m.32814 sp TRIM2_MOUSE 28.492 179 116 7 28 201 536 707 6.00E-11 64.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9FPS2 CHOYP_LOC101252175.1.1 m.29712 sp UBP25_ARATH 26.1 341 194 20 14 310 9 335 6.00E-13 72.8 UBP25_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (AtUBP25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) UBP25 At3g14400 MLN21.18 Arabidopsis thaliana (Mouse-ear cress) 661 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016579; GO:0036459 0 0 0 PF00443; Q9H2P9 CHOYP_LOC577892.2.2 m.18509 sp DPH5_HUMAN 68.231 277 86 2 1 276 1 276 6.00E-145 411 DPH5_HUMAN reviewed Diphthine methyl ester synthase (EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase) DPH5 AD-018 CGI-30 HSPC143 NPD015 Homo sapiens (Human) 285 peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183] GO:0004164; GO:0005829; GO:0017183 PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. 0 cd11647; PF00590; Q9NUA8 CHOYP_LOC100693637.2.4 m.47781 sp ZBT40_HUMAN 29.839 124 84 1 3 126 4 124 6.00E-06 52.8 ZBT40_HUMAN reviewed Zinc finger and BTB domain-containing protein 40 ZBTB40 KIAA0478 Homo sapiens (Human) 1239 "bone mineralization [GO:0030282]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0006974; GO:0030282; GO:0046872 0 0 0 PF00651; Q9QYS2 CHOYP_LOC100374272.5.6 m.57085 sp GRM3_MOUSE 27.041 784 524 20 2027 2784 57 818 6.00E-69 255 GRM3_MOUSE reviewed Metabotropic glutamate receptor 3 (mGluR3) Grm3 Gprc1c Mglur3 Mus musculus (Mouse) 879 "regulation of sensory perception of pain [GO:0051930]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]; synaptic transmission, glutamatergic [GO:0035249]" GO:0001641; GO:0005246; GO:0005886; GO:0005887; GO:0014069; GO:0019233; GO:0030424; GO:0035249; GO:0042734; GO:0043005; GO:0043197; GO:0045211; GO:0048786; GO:0051930; GO:0051966 0 0 0 PF00003;PF01094;PF07562; B3EWZ3 CHOYP_SEM5A.1.2 m.13868 sp CADN_ACRMI 46.565 131 56 6 80 210 223 339 6.01E-24 104 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; G5ED84 CHOYP_ZBTB5.2.4 m.15718 sp KLHL8_CAEEL 29.586 169 108 7 8 172 88 249 6.01E-09 62.8 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O35094 CHOYP_LOC100878391.1.1 m.28644 sp TIM44_RAT 42.152 446 247 4 26 463 11 453 6.01E-121 363 TIM44_RAT reviewed Mitochondrial import inner membrane translocase subunit TIM44 Timm44 Mimt44 Tim44 Rattus norvegicus (Rat) 453 intracellular protein transport [GO:0006886]; protein import into mitochondrial matrix [GO:0030150] GO:0005524; GO:0005743; GO:0006886; GO:0030150; GO:0051087 0 0 0 PF04280; O75179 CHOYP_LOC581927.14.27 m.38992 sp ANR17_HUMAN 29.636 550 306 17 1414 1950 208 689 6.01E-41 171 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75179 CHOYP_LOC762964.7.10 m.41551 sp ANR17_HUMAN 35.167 509 283 17 197 689 236 713 6.01E-54 204 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P22897 CHOYP_LOC420515.1.1 m.15613 sp MRC1_HUMAN 26.866 1206 775 41 506 1663 238 1384 6.01E-105 373 MRC1_HUMAN reviewed Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0001618; GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0005887; GO:0006898; GO:0009986; GO:0010008; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; P25291 CHOYP_BRAFLDRAFT_69120.1.3 m.21994 sp GP2_CANLF 32.824 131 77 5 25 150 28 152 6.01E-10 62 GP2_CANLF reviewed Pancreatic secretory granule membrane major glycoprotein GP2 (Pancreatic zymogen granule membrane protein GP-2) GP2 Canis lupus familiaris (Dog) (Canis familiaris) 509 0 GO:0005576; GO:0005886; GO:0031225 0 0 0 PF00100; P40872 CHOYP_LOC100922325.1.2 m.25236 sp PKSM_BACSU 20.904 354 244 12 8 335 960 1303 6.01E-10 66.6 PKSM_BACSU reviewed Polyketide synthase PksM pksM pksY BSU17200 Bacillus subtilis (strain 168) 4262 antibiotic biosynthetic process [GO:0017000] GO:0005737; GO:0016747; GO:0017000; GO:0031177 PATHWAY: Antibiotic biosynthesis; bacillaene biosynthesis. 0 0 PF16197;PF00109;PF02801;PF08659;PF08242;PF00550;PF14765; Q2TGI8 CHOYP_ERFB.1.1 m.14914 sp ZDH22_RAT 32.716 162 104 4 165 323 91 250 6.01E-16 80.1 ZDH22_RAT reviewed Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22) Zdhhc22 Rattus norvegicus (Rat) 263 protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345] GO:0005783; GO:0005794; GO:0008270; GO:0016021; GO:0018345; GO:0019706; GO:0072659 0 0 0 PF01529; Q32KU3 CHOYP_DLAT.1.1 m.64813 sp MORN2_BOVIN 56.962 79 34 0 128 206 1 79 6.01E-25 95.9 MORN2_BOVIN reviewed MORN repeat-containing protein 2 MORN2 Bos taurus (Bovine) 79 0 0 0 0 0 PF02493; Q63072 CHOYP_TTC1.2.2 m.60702 sp BST1_RAT 31.841 201 126 6 24 223 48 238 6.01E-25 103 BST1_RAT reviewed ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPr hydrolase 2) (CD antigen CD157) Bst1 Rattus norvegicus (Rat) 319 positive regulation of B cell proliferation [GO:0030890] GO:0003953; GO:0005886; GO:0016740; GO:0016849; GO:0030890; GO:0031225; GO:0050135 0 0 0 PF02267; Q86SQ9 CHOYP_BRAFLDRAFT_281462.1.1 m.12546 sp DHDDS_HUMAN 56.061 330 139 2 1 326 1 328 6.01E-129 374 DHDDS_HUMAN reviewed Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Epididymis tissue protein Li 189m) DHDDS HDS Homo sapiens (Human) 333 dolichyl diphosphate biosynthetic process [GO:0006489]; protein glycosylation [GO:0006486] GO:0005789; GO:0006486; GO:0006489; GO:0016765 PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}. 0 cd00475; PF01255; Q8BH18 CHOYP_BRAFLDRAFT_236042.1.1 m.53182 sp TM117_MOUSE 54.229 402 180 3 242 640 3 403 6.01E-153 457 TM117_MOUSE reviewed Transmembrane protein 117 Tmem117 Mus musculus (Mouse) 514 0 GO:0005783; GO:0016021 0 0 0 PF15113; Q8N2E2 CHOYP_LOC101174005.1.1 m.2407 sp VWDE_HUMAN 26.957 230 139 8 405 623 404 615 6.01E-12 73.9 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q96MM6 CHOYP_HSPA12A.9.27 m.34375 sp HS12B_HUMAN 29.348 644 380 17 992 1564 47 686 6.01E-76 270 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9P2F6 CHOYP_LOC582570.1.1 m.65944 sp RHG20_HUMAN 35.113 618 353 14 310 908 38 626 6.01E-99 350 RHG20_HUMAN reviewed Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20) ARHGAP20 KIAA1391 Homo sapiens (Human) 1191 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00788;PF00620; O08684 CHOYP_DGRI_GH20939.1.1 m.50618 sp PLD1_CRIGR 31.731 104 62 1 59 153 51 154 6.02E-13 68.6 PLD1_CRIGR reviewed Phospholipase D1 (PLD 1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) PLD1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 1036 inositol lipid-mediated signaling [GO:0048017]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654] GO:0000139; GO:0004630; GO:0005789; GO:0006654; GO:0016042; GO:0031902; GO:0035091; GO:0048017; GO:0048471; GO:0070290 0 0 0 PF00169;PF00614;PF13091;PF00787; P28799 CHOYP_BRAFLDRAFT_102424.5.6 m.60048 sp GRN_HUMAN 36.742 264 148 5 20 276 113 364 6.02E-49 174 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P49641 CHOYP_BRAFLDRAFT_216484.1.1 m.40095 sp MA2A2_HUMAN 31.296 409 247 11 66 460 761 1149 6.02E-58 211 MA2A2_HUMAN reviewed "Alpha-mannosidase 2x (EC 3.2.1.114) (Alpha-mannosidase IIx) (Man IIx) (Mannosidase alpha class 2A member 2) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase)" MAN2A2 MANA2X Homo sapiens (Human) 1150 mannose metabolic process [GO:0006013]; N-glycan processing [GO:0006491]; protein deglycosylation [GO:0006517] GO:0000139; GO:0004559; GO:0004572; GO:0006013; GO:0006491; GO:0006517; GO:0008270; GO:0016021; GO:0016799; GO:0030246 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09261;PF01074;PF07748; Q4LDE5 CHOYP_LOC100367084.3.22 m.29143 sp SVEP1_HUMAN 25.057 870 481 30 76 815 332 1160 6.02E-43 175 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5RAP9 CHOYP_LOC100182289.1.2 m.27247 sp AT5G2_PONAB 61.062 113 30 2 4 116 42 140 6.02E-39 130 AT5G2_PONAB reviewed "ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase proteolipid P2) (ATPase protein 9) (ATPase subunit c)" ATP5G2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 141 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0008289; GO:0015078; GO:0015986; GO:0015991; GO:0016021; GO:0031966; GO:0045263 0 0 0 PF00137; Q6DIB5 CHOYP_LOC579946.19.24 m.53963 sp MEG10_MOUSE 39.308 318 171 14 41 354 271 570 6.02E-42 159 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6GN15 CHOYP_CCNL1.1.2 m.9018 sp CCNL1_XENLA 64.565 333 97 5 9 327 22 347 6.02E-149 436 CCNL1_XENLA reviewed Cyclin-L1 ccnl1 Xenopus laevis (African clawed frog) 496 "regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of transcription, DNA-templated [GO:0006355]; RNA processing [GO:0006396]; transcription, DNA-templated [GO:0006351]" GO:0000079; GO:0006351; GO:0006355; GO:0006396; GO:0016607 0 0 0 PF00134; Q922J9 CHOYP_FACR1.2.2 m.63340 sp FACR1_MOUSE 44.864 477 263 0 1 477 22 498 6.02E-167 484 FACR1_MOUSE reviewed Fatty acyl-CoA reductase 1 (EC 1.2.1.n2) (Male sterility domain-containing protein 2) Far1 Mlstd2 Mus musculus (Mouse) 515 ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025] GO:0005777; GO:0005778; GO:0008611; GO:0010025; GO:0016021; GO:0035336; GO:0046474; GO:0050062; GO:0080019 0 0 cd09071; PF07993;PF03015; Q98943 CHOYP_BRAFLDRAFT_81923.1.1 m.66586 sp CASP2_CHICK 29.56 159 80 3 17 168 170 303 6.02E-11 66.6 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9C040 CHOYP_TRIM2.50.59 m.55658 sp TRIM2_HUMAN 22.695 282 163 8 325 561 472 743 6.02E-11 68.9 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9UEW3 CHOYP_OTOL1.1.1 m.43359 sp MARCO_HUMAN 42.453 212 108 5 216 414 220 430 6.02E-20 95.5 MARCO_HUMAN reviewed Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2) MARCO SCARA2 Homo sapiens (Human) 520 apoptotic cell clearance [GO:0043277]; cell surface receptor signaling pathway [GO:0007166]; innate immune response [GO:0045087]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005581; GO:0005886; GO:0005887; GO:0006898; GO:0007166; GO:0008329; GO:0030666; GO:0043277; GO:0045087 0 0 0 PF01391;PF00530; Q9VCA8 CHOYP_LOC583072.7.25 m.35648 sp ANKHM_DROME 34.651 430 256 13 382 796 588 1007 6.02E-51 200 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9WV92 CHOYP_E41L3.1.2 m.25633 sp E41L3_MOUSE 58.529 340 135 4 4 342 120 454 6.02E-135 439 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; A4IIA7 CHOYP_CG060.2.2 m.58588 sp BMT2_XENTR 48.387 93 44 3 7 96 36 127 6.03E-18 81.3 BMT2_XENTR reviewed Probable methyltransferase BTM2 homolog (EC 2.1.1.-) 0 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 400 0 GO:0016433 0 0 0 PF11968; A8XZB0 CHOYP_LOC100374535.3.3 m.31001 sp ATIF2_CAEBR 54.286 70 32 0 57 126 32 101 6.03E-17 73.9 ATIF2_CAEBR reviewed "ATPase inhibitor mai-2, mitochondrial" mai-2 CBG21048 Caenorhabditis briggsae 109 heme biosynthetic process [GO:0006783]; negative regulation of ATPase activity [GO:0032780] GO:0005739; GO:0006783; GO:0032780; GO:0042030; GO:0051117 0 0 0 PF04568; B3EWZ3 CHOYP_BRAFLDRAFT_88566.7.11 m.28558 sp CADN_ACRMI 44.018 443 237 4 546 979 131 571 6.03E-110 380 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; P16157 CHOYP_TVAG_168010.25.45 m.52984 sp ANK1_HUMAN 30.786 458 294 5 65 522 139 573 6.03E-57 209 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P22105 CHOYP_LOC100176721.1.6 m.39201 sp TENX_HUMAN 36.044 455 220 24 75 501 190 601 6.03E-31 131 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P52841 CHOYP_LOC100037047.1.1 m.3882 sp SUHB_CAVPO 33.094 139 82 4 17 146 5 141 6.03E-14 71.2 SUHB_CAVPO reviewed 3-beta-hydroxysteroid sulfotransferase (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2) (HST2) (Pregnenolone sulfotransferase) STD2 Cavia porcellus (Guinea pig) 287 steroid metabolic process [GO:0008202] GO:0004027; GO:0005737; GO:0008202 0 0 0 PF00685; P61805 CHOYP_LOC578220.2.2 m.22024 sp DAD1_RAT 73.214 112 30 0 298 409 2 113 6.03E-54 177 DAD1_RAT reviewed Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (EC 2.4.99.18) (Defender against cell death 1) (DAD-1) Dad1 Rattus norvegicus (Rat) 113 apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of apoptotic process [GO:0043066]; protein glycosylation [GO:0006486]; response to drug [GO:0042493]; response to nutrient [GO:0007584] GO:0001824; GO:0004579; GO:0006486; GO:0006915; GO:0007584; GO:0008250; GO:0016021; GO:0042493; GO:0043066; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02109; Q1LX59 CHOYP_BRAFLDRAFT_116078.1.1 m.27592 sp C2512_DANRE 50.385 260 126 2 29 287 12 269 6.03E-87 265 C2512_DANRE reviewed "Cholesterol 25-hydroxylase-like protein 1, member 2 (EC 1.14.99.-)" ch25hl1.2 si:dkey-24l11.9 Danio rerio (Zebrafish) (Brachydanio rerio) 276 fatty acid biosynthetic process [GO:0006633]; sterol biosynthetic process [GO:0016126] GO:0004497; GO:0005506; GO:0005789; GO:0006633; GO:0016021; GO:0016126 0 0 0 PF04116; Q24407 CHOYP_DANA_GF18010.1.1 m.6864 sp ATP5J_DROME 35.922 103 58 3 5 106 4 99 6.03E-10 56.6 ATP5J_DROME reviewed "ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6)" ATPsynCf6 CG4412 Drosophila melanogaster (Fruit fly) 106 ATP synthesis coupled proton transport [GO:0015986]; lateral inhibition [GO:0046331] GO:0000276; GO:0005739; GO:0015078; GO:0015986; GO:0046331 0 0 0 PF05511; Q27433 CHOYP_MEC2.3.4 m.30735 sp MEC2_CAEEL 73.684 247 64 1 2 247 123 369 6.03E-118 348 MEC2_CAEEL reviewed Mechanosensory protein 2 mec-2 F14D12.4 Caenorhabditis elegans 481 mechanosensory behavior [GO:0007638]; response to mechanical stimulus [GO:0009612] GO:0007638; GO:0009612; GO:0015485; GO:0016021; GO:0032589; GO:0043005 0 0 0 PF01145; Q4UMH6 CHOYP_TVAG_287350.3.5 m.18540 sp Y381_RICFE 22.481 516 343 16 11 505 673 1152 6.03E-14 79.3 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5RID7 CHOYP_BRAFLDRAFT_240864.1.1 m.24434 sp SNX17_DANRE 49.58 476 202 4 30 470 1 473 6.03E-167 481 SNX17_DANRE reviewed Sorting nexin-17 snx17 si:ch211-101l18.2 Danio rerio (Zebrafish) (Brachydanio rerio) 473 "intracellular protein transport [GO:0006886]; retrograde transport, endosome to plasma membrane [GO:1990126]; signal transduction [GO:0007165]" GO:0005769; GO:0005829; GO:0006886; GO:0007165; GO:0016023; GO:0030659; GO:0035091; GO:1990126 0 0 0 PF00787; Q63184 CHOYP_LOC100208179.2.3 m.35144 sp E2AK2_RAT 32.951 349 174 12 34 379 197 488 6.03E-38 148 E2AK2_RAT reviewed "Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2)" Eif2ak2 Prkr Rattus norvegicus (Rat) 513 "activation of MAPKK activity [GO:0000186]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of osteoblast proliferation [GO:0033689]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production [GO:0001819]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of NLRP3 inflammasome complex assembly [GO:1900225]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to exogenous dsRNA [GO:0043330]; response to interferon-alpha [GO:0035455]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to organic substance [GO:0010033]; response to toxic substance [GO:0009636]; response to virus [GO:0009615]; response to vitamin E [GO:0033197]; transcription, DNA-templated [GO:0006351]" GO:0000186; GO:0001819; GO:0003725; GO:0004672; GO:0004674; GO:0004715; GO:0005524; GO:0005634; GO:0005737; GO:0006351; GO:0006468; GO:0009612; GO:0009615; GO:0009636; GO:0010033; GO:0010998; GO:0017148; GO:0032496; GO:0032722; GO:0032874; GO:0033197; GO:0033689; GO:0035455; GO:0043065; GO:0043330; GO:0045071; GO:0045087; GO:0046777; GO:0048471; GO:0051092; GO:0051607; GO:1900225; GO:1901224; GO:1901532; GO:1902033; GO:1902036 0 0 0 PF00035;PF00069; Q6PHU5 CHOYP_LOC100313736.1.1 m.59857 sp SORT_MOUSE 36.272 794 453 21 48 827 69 823 6.03E-159 488 SORT_MOUSE reviewed Sortilin (Neurotensin receptor 3) (NTR3) (mNTR3) Sort1 Mus musculus (Mouse) 825 endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose import [GO:0046323]; Golgi to endosome transport [GO:0006895]; G-protein coupled receptor signaling pathway [GO:0007186]; multicellular organism development [GO:0007275]; myotube differentiation [GO:0014902]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of lipoprotein lipase activity [GO:0051005]; neuropeptide signaling pathway [GO:0007218]; neurotrophin TRK receptor signaling pathway [GO:0048011]; ossification [GO:0001503]; plasma membrane to endosome transport [GO:0048227]; positive regulation of epithelial cell apoptotic process [GO:1904037]; regulation of gene expression [GO:0010468]; response to insulin [GO:0032868]; vesicle organization [GO:0016050] GO:0001503; GO:0005765; GO:0005769; GO:0005789; GO:0005794; GO:0005829; GO:0005886; GO:0005905; GO:0006895; GO:0006897; GO:0007186; GO:0007218; GO:0007275; GO:0008333; GO:0008625; GO:0009986; GO:0010008; GO:0010465; GO:0010468; GO:0014902; GO:0016021; GO:0016023; GO:0016050; GO:0019899; GO:0030136; GO:0030140; GO:0030379; GO:0030425; GO:0031965; GO:0032509; GO:0032580; GO:0032868; GO:0043025; GO:0045599; GO:0046323; GO:0048011; GO:0048227; GO:0048406; GO:0048471; GO:0051005; GO:1904037 0 0 0 PF15902;PF15901; Q80ZA4 CHOYP_BRAFLDRAFT_71586.1.1 m.40464 sp PKHL1_MOUSE 36.782 522 286 10 1 503 3674 4170 6.03E-94 320 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q9BXW7 CHOYP_CECR5.1.1 m.40218 sp CECR5_HUMAN 42.424 132 75 1 37 167 43 174 6.03E-27 109 CECR5_HUMAN reviewed Cat eye syndrome critical region protein 5 CECR5 Homo sapiens (Human) 423 glycerophospholipid biosynthetic process [GO:0046474] GO:0005739; GO:0046474 0 0 0 PF13344; Q9H2F5 CHOYP_LOC100374204.1.1 m.14343 sp EPC1_HUMAN 51.465 546 209 8 1 493 1 543 6.03E-173 520 EPC1_HUMAN reviewed Enhancer of polycomb homolog 1 EPC1 Homo sapiens (Human) 836 "histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of growth [GO:0040008]; transcription, DNA-templated [GO:0006351]; vascular smooth muscle cell differentiation [GO:0035886]" GO:0000122; GO:0005634; GO:0005654; GO:0006351; GO:0031965; GO:0032777; GO:0035267; GO:0035886; GO:0040008; GO:0043967; GO:0043968; GO:0045814; GO:0045892; GO:0045893; GO:0045944 0 0 0 PF06752;PF10513; Q9I8C7 CHOYP_ACH10.1.2 m.34122 sp ACH10_CHICK 29.263 434 281 10 38 460 33 451 6.03E-58 200 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; G5ED84 CHOYP_ZBTB5.3.4 m.30995 sp KLHL8_CAEEL 29.586 169 108 7 8 172 88 249 6.04E-09 62.8 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O35963 CHOYP_LOC100367291.1.1 m.51818 sp RB33B_MOUSE 74.719 178 45 0 25 202 29 206 6.04E-102 298 RB33B_MOUSE reviewed Ras-related protein Rab-33B Rab33b Mus musculus (Mouse) 229 "autophagy [GO:0006914]; intra-Golgi vesicle-mediated transport [GO:0006891]; negative regulation of constitutive secretory pathway [GO:1903434]; protein targeting to Golgi [GO:0000042]; regulation of autophagosome assembly [GO:2000785]; regulation of Golgi organization [GO:1903358]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; skeletal system morphogenesis [GO:0048705]; small GTPase mediated signal transduction [GO:0007264]" GO:0000042; GO:0000139; GO:0003924; GO:0005525; GO:0005794; GO:0005796; GO:0006891; GO:0006914; GO:0007264; GO:0048705; GO:0070062; GO:1903358; GO:1903434; GO:2000156; GO:2000785 0 0 0 PF00071; O76190 CHOYP_RPL5.1.1 m.55846 sp RL5_BOMMO 58.696 92 37 1 23 113 205 296 6.04E-30 111 RL5_BOMMO reviewed 60S ribosomal protein L5 RpL5 Bombyx mori (Silk moth) 299 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; O93603 CHOYP_5HT2A.1.1 m.43293 sp TRFR_CHICK 22.753 356 210 13 46 393 39 337 6.04E-08 57.8 TRFR_CHICK reviewed Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor) TRHR Gallus gallus (Chicken) 395 0 GO:0004997; GO:0005886; GO:0016021 0 0 0 PF00001; P05300 CHOYP_LAMP1.1.3 m.4165 sp LAMP1_CHICK 28.608 388 202 16 326 678 67 414 6.04E-25 111 LAMP1_CHICK reviewed Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (Lysosome membrane glycoprotein LEP100) LAMP1 Gallus gallus (Chicken) 414 0 GO:0005765; GO:0005770; GO:0005886; GO:0010008; GO:0016020; GO:0016021 0 0 0 PF01299; Q11212 CHOYP_ACT3.2.3 m.23311 sp ACT_SPOLI 98.81 84 1 0 1 84 63 146 6.04E-58 179 ACT_SPOLI reviewed Actin (Fragment) 0 Spodoptera littoralis (Egyptian cotton leafworm) 164 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q2HJ10 CHOYP_LOC100178917.1.1 m.41458 sp ZNT2_MOUSE 45.013 371 158 3 56 422 40 368 6.04E-113 338 ZNT2_MOUSE reviewed Zinc transporter 2 (ZnT-2) (Solute carrier family 30 member 2) Slc30a2 Znt2 Mus musculus (Mouse) 371 positive regulation of sequestering of zinc ion [GO:0061090]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043] GO:0005385; GO:0005737; GO:0005765; GO:0005770; GO:0005886; GO:0010043; GO:0016021; GO:0016023; GO:0061088; GO:0061090 0 0 0 PF01545; Q2V898 CHOYP_TLR13.3.5 m.32018 sp TLR4_BOSTR 25 432 286 16 419 840 413 816 6.04E-26 118 TLR4_BOSTR reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Boselaphus tragocamelus (Nilgai) 841 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142] GO:0001875; GO:0002755; GO:0004888; GO:0005886; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13306;PF13855;PF01582; Q6AXX4 CHOYP_ISCW_ISCW011328.1.1 m.8861 sp SAS10_RAT 38.254 481 247 9 30 506 36 470 6.04E-82 265 SAS10_RAT reviewed Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (Disrupter of silencing SAS10) (UTP3 homolog) Utp3 Crlz1 Sas10 Rattus norvegicus (Rat) 470 "brain development [GO:0007420]; covalent chromatin modification [GO:0016569]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]" GO:0000462; GO:0005634; GO:0005730; GO:0007420; GO:0016569; GO:0032040; GO:0044822 0 0 0 PF09368;PF04000; Q7ZX37 CHOYP_BRAFLDRAFT_84996.1.1 m.14438 sp JMD6B_XENLA 27.076 277 159 8 126 384 42 293 6.04E-18 88.6 JMD6B_XENLA reviewed Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-B (EC 1.14.11.-) (Histone arginine demethylase JMJD6-B) (JmjC domain-containing protein 6-B) (Jumonji domain-containing protein 6-B) (Lysyl-hydroxylase JMJD6-B) (Peptide-lysine 5-dioxygenase JMJD6-B) (Phosphatidylserine receptor-B) (Protein PTDSR-B) jmjd6-b ptdsr-b Xenopus laevis (African clawed frog) 403 "cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine [GO:0018395]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; sprouting angiogenesis [GO:0002040]; transcription, DNA-templated [GO:0006351]" GO:0002040; GO:0003727; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0018395; GO:0030154; GO:0033746; GO:0033749; GO:0046872; GO:0048024; GO:0070815 0 0 0 PF02373; Q86XL3 CHOYP_ANKLE2.1.1 m.6635 sp ANKL2_HUMAN 36.364 352 172 9 1 305 65 411 6.04E-57 200 ANKL2_HUMAN reviewed Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) ANKLE2 KIAA0692 LEM4 Homo sapiens (Human) 938 cell division [GO:0051301]; central nervous system development [GO:0007417]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope reassembly [GO:0007084]; negative regulation of apoptotic process [GO:0043066]; negative regulation of phosphorylation [GO:0042326]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of catalytic activity [GO:0050790] GO:0005789; GO:0007067; GO:0007084; GO:0007417; GO:0008601; GO:0016020; GO:0030176; GO:0035307; GO:0042326; GO:0043066; GO:0050790; GO:0051301; GO:0051721 0 0 0 PF01693;PF03020; Q8BH66 CHOYP_ATLA1.1.4 m.35226 sp ATLA1_MOUSE 37.108 415 249 4 183 595 30 434 6.04E-85 284 ATLA1_MOUSE reviewed Atlastin-1 (EC 3.6.5.-) (Spastic paraplegia 3A homolog) Atl1 Spg3a Mus musculus (Mouse) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; protein homooligomerization [GO:0051260] GO:0000137; GO:0000139; GO:0003924; GO:0005525; GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0007029; GO:0007409; GO:0016021; GO:0030424; GO:0042802; GO:0051260 0 0 0 PF02263; Q8JGT5 CHOYP_SAE1.1.1 m.46861 sp SAE1_XENLA 54.706 340 150 2 3 339 5 343 6.04E-136 393 SAE1_XENLA reviewed SUMO-activating enzyme subunit 1 (SUMO-activating enzyme E1 N subunit) (Ubiquitin-like 1-activating enzyme E1A) sae1 uble1a Xenopus laevis (African clawed frog) 344 protein sumoylation [GO:0016925] GO:0005634; GO:0008641; GO:0016925 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00899; Q9JI18 CHOYP_LOC578656.2.15 m.11315 sp LRP1B_MOUSE 26.286 894 564 36 126 975 1340 2182 6.04E-59 228 LRP1B_MOUSE reviewed Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) 4599 in utero embryonic development [GO:0001701] GO:0001701; GO:0005041; GO:0005509; GO:0016020; GO:0016021; GO:0043235; GO:0050750 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q9ULJ7 CHOYP_LOC583072.6.25 m.33002 sp ANR50_HUMAN 33.696 460 272 16 12 453 496 940 6.04E-44 169 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; A0A0R4IBK5 CHOYP_LOC100537840.1.1 m.55651 sp R213A_DANRE 21.75 777 498 33 292 1021 140 853 6.05E-11 71.2 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 A4IF63 CHOYP_BRAFLDRAFT_87283.1.1 m.46768 sp TRIM2_BOVIN 27.333 150 95 3 7 154 607 744 6.05E-06 48.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B2RU80 CHOYP_PTPRD.3.3 m.60153 sp PTPRB_MOUSE 30.525 819 475 26 874 1652 1228 1992 6.05E-88 322 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; F4JAU3 CHOYP_DFA_07312.2.2 m.47255 sp P4H2_ARATH 28.431 204 102 9 19 189 47 239 6.05E-06 48.9 P4H2_ARATH reviewed Prolyl 4-hydroxylase 2 (AtP4H-2) (AtP4H2) (EC 1.14.11.2) P4H2 At3g06300 F24P17.24 Arabidopsis thaliana (Mouse-ear cress) 299 peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; root hair cell development [GO:0080147] GO:0000139; GO:0004656; GO:0005506; GO:0005768; GO:0005789; GO:0005794; GO:0005802; GO:0016021; GO:0018401; GO:0031418; GO:0080147 0 0 0 PF13640; H2A0L8 CHOYP_FND2.3.4 m.40482 sp FND2_PINMG 46.422 573 280 7 26 575 39 607 6.05E-152 457 FND2_PINMG reviewed Fibronectin type III domain-containing protein 2 0 Pinctada margaritifera (Black-lipped pearl oyster) 624 0 GO:0005576 0 0 0 PF00041; H2A0M7 CHOYP_LOC100743516.1.1 m.54391 sp PLSP_PINMG 36.364 594 323 19 47 597 152 733 6.05E-98 319 PLSP_PINMG reviewed Peroxidase-like protein 0 Pinctada margaritifera (Black-lipped pearl oyster) 793 response to oxidative stress [GO:0006979] GO:0004601; GO:0005576; GO:0006979; GO:0020037 0 0 0 PF03098; O00214 CHOYP_LOC100378205.1.1 m.51543 sp LEG8_HUMAN 39.416 137 77 2 63 199 185 315 6.05E-28 110 LEG8_HUMAN reviewed Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) LGALS8 Homo sapiens (Human) 317 xenophagy [GO:0098792] GO:0005615; GO:0005829; GO:0016020; GO:0030246; GO:0070062; GO:0098792 0 0 0 PF00337; O75096 CHOYP_LOC578656.1.15 m.6686 sp LRP4_HUMAN 29.266 926 579 28 95 998 472 1343 6.05E-113 390 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; O75382 CHOYP_BRAFLDRAFT_87268.4.4 m.64638 sp TRIM3_HUMAN 27.642 123 84 3 161 279 622 743 6.05E-07 54.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P10079 CHOYP_TRIADDRAFT_26462.1.2 m.4097 sp FBP1_STRPU 35.459 643 370 23 196 806 202 831 6.05E-87 301 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P18503 CHOYP_BRAFLDRAFT_76550.8.21 m.48624 sp CAS4_EPHMU 31.746 126 72 3 103 228 202 313 6.05E-06 50.4 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P41126 CHOYP_LOC656265.1.1 m.14824 sp RL13_DROME 64.706 102 36 0 4 105 13 114 6.05E-43 142 RL13_DROME reviewed 60S ribosomal protein L13 (BBC1 protein homolog) RpL13 bbc1 CG4651 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; translation [GO:0006412] GO:0000022; GO:0003723; GO:0003735; GO:0005840; GO:0006412; GO:0007052; GO:0022625; GO:0051298 0 0 0 PF01294; P87367 CHOYP_OPSR.1.1 m.11925 sp OPSR_ORYLA 24.49 294 197 8 37 316 52 334 6.05E-14 75.1 OPSR_ORYLA reviewed Red-sensitive opsin (KFH-R) (Red cone photoreceptor pigment) 0 Oryzias latipes (Japanese rice fish) (Japanese killifish) 357 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0004930; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; Q5XIG2 CHOYP_LOC100371610.2.2 m.45180 sp C1QT1_RAT 32.609 138 89 2 49 182 144 281 6.05E-15 74.3 C1QT1_RAT reviewed Complement C1q tumor necrosis factor-related protein 1 C1qtnf1 Rattus norvegicus (Rat) 281 0 GO:0005576; GO:0005581 0 0 0 PF00386;PF01391; Q6NS45 CHOYP_BRAFLDRAFT_121183.5.8 m.31443 sp CCD66_MOUSE 39.098 133 81 0 770 902 438 570 6.05E-13 77.4 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q7TP17 CHOYP_BRAFLDRAFT_202693.3.4 m.26807 sp U2AF4_RAT 79.195 149 24 2 2 149 54 196 6.05E-82 247 U2AF4_RAT reviewed Splicing factor U2AF 26 kDa subunit (Liver regeneration-related protein LRRG157/LRRG158) (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) U2af1l4 Cb2-806 Cb2-807 Rattus norvegicus (Rat) 220 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005681; GO:0005737; GO:0016607; GO:0046872; GO:0089701 0 0 0 PF00076;PF00642; Q8N7X2 CHOYP_LOC100175702.1.1 m.56240 sp CI173_HUMAN 37.975 79 47 2 222 299 94 171 6.05E-07 54.7 CI173_HUMAN reviewed Uncharacterized protein C9orf173 C9orf173 Homo sapiens (Human) 389 0 0 0 0 0 0 Q8WZ42 CHOYP_HMCN2.9.12 m.44986 sp TITIN_HUMAN 22.602 615 368 26 352 920 7302 7854 6.05E-16 87.4 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q99P55 CHOYP_SGPP1.1.1 m.5606 sp SGPP1_RAT 38.642 427 248 7 41 464 14 429 6.05E-85 270 SGPP1_RAT reviewed Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) Sgpp1 Rattus norvegicus (Rat) 430 0 GO:0005789; GO:0016021; GO:0016787 0 0 0 PF01569; Q9MYN5 CHOYP_LOC580574.1.1 m.4953 sp CDKN3_PIG 48.864 176 90 0 27 202 10 185 6.05E-57 184 CDKN3_PIG reviewed Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Kinase-associated phosphatase) CDKN3 KAP Sus scrofa (Pig) 212 cell cycle arrest [GO:0007050]; G1/S transition of mitotic cell cycle [GO:0000082] GO:0000082; GO:0004722; GO:0004725; GO:0005634; GO:0005737; GO:0007050; GO:0008138; GO:0048471 0 0 0 PF05706; Q9ULF5 CHOYP_S39AA.2.3 m.63503 sp S39AA_HUMAN 61.783 157 56 2 2 154 669 825 6.05E-63 209 S39AA_HUMAN reviewed Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10) SLC39A10 KIAA1265 ZIP10 Homo sapiens (Human) 831 cellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; zinc II ion transmembrane import [GO:0071578] GO:0002903; GO:0005385; GO:0005887; GO:0006882; GO:0030890; GO:0050861; GO:0071578; GO:1903615 0 0 0 PF02535; A1BQQ5 CHOYP_LOC764722.2.3 m.42252 sp MR30_CONMR 37.692 130 63 5 9 128 167 288 6.06E-15 76.6 MR30_CONMR reviewed Cysteine-rich venom protein Mr30 (CRVP) (Cysteine-rich secretory protein Mr30) (GlaCrisp isoform 1/2/3) (Mr30-1/2) 0 Conus marmoreus (Marble cone) 289 0 GO:0005576 0 0 0 PF00188; B2RX14 CHOYP_TUT4.1.2 m.23151 sp TUT4_MOUSE 58.14 129 50 2 8 135 1201 1326 6.06E-45 169 TUT4_MOUSE reviewed Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11) Zcchc11 Kiaa0191 Tut4 Mus musculus (Mouse) 1644 cytokine production [GO:0001816]; interleukin-6-mediated signaling pathway [GO:0070102]; miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of interleukin-6 production [GO:0032755]; pre-miRNA processing [GO:0031054]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827] GO:0001816; GO:0005615; GO:0005634; GO:0005730; GO:0005737; GO:0008270; GO:0010586; GO:0010587; GO:0019827; GO:0031054; GO:0031123; GO:0031664; GO:0032088; GO:0032755; GO:0044822; GO:0050265; GO:0070062; GO:0070102 0 0 0 PF01909;PF03828;PF00098; B5DGL6 CHOYP_RS3A.12.15 m.49133 sp RS3A_SALSA 80.769 104 19 1 13 116 44 146 6.06E-55 176 RS3A_SALSA reviewed 40S ribosomal protein S3a rps3a Salmo salar (Atlantic salmon) 266 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; D2GXS7 CHOYP_BRAFLDRAFT_241726.11.22 m.32648 sp TRIM2_AILME 23.643 258 180 8 23 268 492 744 6.06E-07 53.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O05972 CHOYP_LOC574855.9.9 m.61104 sp Y028_RICPR 31.683 101 66 3 97 195 47 146 6.06E-07 52.8 Y028_RICPR reviewed Uncharacterized protein RP028 RP028 Rickettsia prowazekii (strain Madrid E) 250 0 0 0 0 0 PF13847; O35586 CHOYP_BRAFLDRAFT_76431.1.2 m.55155 sp IDI1_MESAU 57.273 220 90 2 46 264 10 226 6.06E-91 271 IDI1_MESAU reviewed Isopentenyl-diphosphate Delta-isomerase 1 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 1) (IPP isomerase 1) (IPPI1) IDI1 Mesocricetus auratus (Golden hamster) 227 cholesterol biosynthetic process [GO:0006695]; dimethylallyl diphosphate biosynthetic process [GO:0050992]; isoprenoid biosynthetic process [GO:0008299] GO:0004452; GO:0005777; GO:0006695; GO:0008299; GO:0016787; GO:0046872; GO:0050992 PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1. 0 cd02885; PF00293; O75071 CHOYP_EFCAB14.1.1 m.61948 sp EFC14_HUMAN 25.441 397 243 13 18 381 1 377 6.06E-14 78.6 EFC14_HUMAN reviewed EF-hand calcium-binding domain-containing protein 14 EFCAB14 KIAA0494 Homo sapiens (Human) 495 0 GO:0005509 0 0 0 0 P31396 CHOYP_LOC663422.1.1 m.57246 sp HR3_DROME 44.304 474 234 10 101 554 18 481 6.06E-126 381 HR3_DROME reviewed Probable nuclear hormone receptor HR3 (dHR3) (Nuclear receptor subfamily 1 group F member 4) Hr46 Hr3 NR1F4 CG11823 Drosophila melanogaster (Fruit fly) 487 "metamorphosis [GO:0007552]; mushroom body development [GO:0016319]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of development, heterochronic [GO:0040034]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0003707; GO:0004879; GO:0004887; GO:0005634; GO:0006351; GO:0007552; GO:0008270; GO:0016319; GO:0040034; GO:0045944 0 0 0 PF00104;PF00105; P46209 CHOYP_NEMVEDRAFT_V1G164392.3.3 m.59980 sp USF_AQUPY 40.351 57 30 2 49 102 27 82 6.06E-07 50.1 USF_AQUPY reviewed Protein usf usf Aquifex pyrophilus 231 0 GO:0016787 0 0 0 PF01738; Q26636 CHOYP_LOC659226.1.3 m.16864 sp CATL_SARPE 55.873 315 132 3 289 596 25 339 6.06E-124 372 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q3T0Y3 CHOYP_LOC100459096.1.3 m.12787 sp ST1B1_BOVIN 35.517 290 157 10 71 343 19 295 6.06E-40 145 ST1B1_BOVIN reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) SULT1B1 Bos taurus (Bovine) 296 epithelial cell differentiation [GO:0030855]; flavonoid metabolic process [GO:0009812]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005737; GO:0006805; GO:0008202; GO:0009812; GO:0030855; GO:0042403; GO:0051923 0 0 0 PF00685; Q6A4L1 CHOYP_DVIR_GJ19220.1.1 m.53570 sp S12A8_XENLA 48.283 495 241 3 63 555 23 504 6.06E-156 466 S12A8_XENLA reviewed Solute carrier family 12 member 8 slc12a8 Xenopus laevis (African clawed frog) 721 potassium ion transport [GO:0006813] GO:0006813; GO:0015293; GO:0016021 0 0 0 PF00324; Q6NS15 CHOYP_MED15.1.3 m.19384 sp MED15_XENLA 52.083 288 127 5 434 718 494 773 6.06E-84 285 MED15_XENLA reviewed Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (xARC105) (Mediator complex subunit 15) med15 arc105 Xenopus laevis (African clawed frog) 777 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0005737; GO:0006351; GO:0016592 0 0 0 PF09606; Q80ZA4 CHOYP_BRAFLDRAFT_119774.2.4 m.17747 sp PKHL1_MOUSE 40.559 572 294 10 1 551 2491 3037 6.06E-134 434 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.3.34 m.3035 sp VWDE_HUMAN 27.147 652 407 23 24 633 1 626 6.06E-56 216 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q90596 CHOYP_MAFK.1.1 m.55009 sp MAFK_CHICK 55.263 114 51 0 18 131 20 133 6.06E-36 124 MAFK_CHICK reviewed Transcription factor MafK MAFK Gallus gallus (Chicken) 156 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0001228; GO:0005634; GO:0005654; GO:0006357; GO:0043565 0 0 0 PF03131; Q95VY2 CHOYP_LOC100373427.1.1 m.49649 sp TCTP_BRABE 42.623 122 65 3 8 129 10 126 6.06E-22 88.2 TCTP_BRABE reviewed Translationally-controlled tumor protein homolog (TCTP) 0 Branchiostoma belcheri (Amphioxus) 169 0 GO:0005737 0 0 0 PF00838; Q96GP6 CHOYP_CRE_01395.1.2 m.19131 sp SREC2_HUMAN 37.209 215 124 8 175 389 236 439 6.06E-27 116 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q99715 CHOYP_COCA1.6.6 m.59427 sp COCA1_HUMAN 45.361 97 51 2 7 102 2321 2416 6.06E-17 77.8 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q9HC21 CHOYP_BRAFLDRAFT_287708.1.1 m.52226 sp TPC_HUMAN 48.101 316 157 5 1 314 1 311 6.06E-95 287 TPC_HUMAN reviewed Mitochondrial thiamine pyrophosphate carrier (Mitochondrial uncoupling protein 1) (Solute carrier family 25 member 19) SLC25A19 DNC MUP1 Homo sapiens (Human) 320 deoxynucleotide transport [GO:0030302]; positive regulation of defense response to virus by host [GO:0002230]; translation [GO:0006412]; xenophagy [GO:0098792] GO:0002230; GO:0003735; GO:0005634; GO:0005743; GO:0006412; GO:0016021; GO:0030233; GO:0030302; GO:0098792 0 0 0 PF00153; A7GCK7 CHOYP_BRAFLDRAFT_275989.1.1 m.18541 sp PSUG_CLOBL 56.574 251 107 2 29 279 6 254 6.07E-93 280 PSUG_CLOBL reviewed Pseudouridine-5'-phosphate glycosidase (PsiMP glycosidase) (EC 4.2.1.70) psuG CLI_1251 Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) 307 nucleobase catabolic process [GO:0046113] GO:0004730; GO:0016798; GO:0046113; GO:0046872 0 0 0 PF04227; B0WIW5 CHOYP_LOC594038.1.1 m.8864 sp DDRGK_CULQU 47.138 297 135 7 8 294 3 287 6.07E-61 198 DDRGK_CULQU reviewed DDRGK domain-containing protein 1 CPIJ007479 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) 287 0 0 0 0 0 PF09756; O01359 CHOYP_LOC100371985.2.3 m.42484 sp RLA1_OSCTI 61.607 112 43 0 1 112 1 112 6.07E-34 116 RLA1_OSCTI reviewed 60S acidic ribosomal protein P1 (Ribosomal protein RPL-21) rpl-21 Oscheius tipulae 112 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O01359 CHOYP_RLA1.10.12 m.37756 sp RLA1_OSCTI 61.607 112 43 0 1 112 1 112 6.07E-34 116 RLA1_OSCTI reviewed 60S acidic ribosomal protein P1 (Ribosomal protein RPL-21) rpl-21 Oscheius tipulae 112 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O42249 CHOYP_LOC101079003.1.1 m.39305 sp GBLP_ORENI 88.571 70 8 0 13 82 156 225 6.07E-39 135 GBLP_ORENI reviewed Guanine nucleotide-binding protein subunit beta-2-like 1 (Receptor of activated protein kinase C) (RACK) gnb2l1 rack1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 317 negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of gastrulation [GO:2000543]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880] GO:0005737; GO:0030178; GO:0032880; GO:0051302; GO:2000114; GO:2000543 0 0 0 PF00400; O43805 CHOYP_BRAFLDRAFT_57176.4.5 m.26759 sp SSNA1_HUMAN 69.027 113 35 0 27 139 1 113 6.07E-51 160 SSNA1_HUMAN reviewed Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa) SSNA1 NA14 Homo sapiens (Human) 119 ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; G2/M transition of mitotic cell cycle [GO:0000086]; intraciliary transport [GO:0042073] GO:0000086; GO:0005634; GO:0005813; GO:0005829; GO:0005886; GO:0036064; GO:0042073; GO:0042802; GO:0060830 0 0 0 0 O57337 CHOYP_LOC100700093.1.1 m.4795 sp HES1_CHICK 28.028 289 175 11 13 293 27 290 6.07E-21 93.6 HES1_CHICK reviewed Transcription factor HES-1 (C-HAIRY1) (Hairy and enhancer of split 1) HES1 HAIRY1 Gallus gallus (Chicken) 290 "negative regulation of neuron differentiation [GO:0045665]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0042803; GO:0045665; GO:0046982 0 0 0 PF07527;PF00010; P07607 CHOYP_LOC100013725.1.2 m.12740 sp TYSY_MOUSE 72.973 296 80 0 67 362 12 307 6.07E-166 468 TYSY_MOUSE reviewed Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) Tyms Mus musculus (Mouse) 307 aging [GO:0007568]; cartilage development [GO:0051216]; circadian rhythm [GO:0007623]; developmental growth [GO:0048589]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; dUMP metabolic process [GO:0046078]; immortalization of host cell by virus [GO:0019088]; intestinal epithelial cell maturation [GO:0060574]; organ regeneration [GO:0031100]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; response to organophosphorus [GO:0046683]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; tetrahydrofolate interconversion [GO:0035999]; uracil metabolic process [GO:0019860] GO:0000166; GO:0003729; GO:0004799; GO:0005542; GO:0005634; GO:0005730; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006231; GO:0006235; GO:0007568; GO:0007623; GO:0008144; GO:0009636; GO:0019088; GO:0019860; GO:0031100; GO:0032570; GO:0033189; GO:0034097; GO:0035999; GO:0042493; GO:0045471; GO:0046078; GO:0046683; GO:0048037; GO:0048589; GO:0051216; GO:0051384; GO:0051593; GO:0060574 PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. 0 0 PF00303; P10394 CHOYP_POL4.3.4 m.44716 sp POL4_DROME 28.732 355 220 9 1 325 672 1023 6.07E-26 114 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P23038 CHOYP_MT.14.18 m.57923 sp MT_CRAVI 55.696 79 29 4 23 99 1 75 6.07E-09 51.6 MT_CRAVI reviewed Metallothionein (MT) 0 Crassostrea virginica (Eastern oyster) 75 0 GO:0046872 0 0 0 0 P35951 CHOYP_LDLR.4.7 m.36371 sp LDLR_MOUSE 40 100 32 2 34 105 80 179 6.07E-14 69.7 LDLR_MOUSE reviewed Low-density lipoprotein receptor (LDL receptor) Ldlr Mus musculus (Mouse) 862 cellular response to fatty acid [GO:0071398]; cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; lipoprotein metabolic process [GO:0042157]; low-density lipoprotein particle clearance [GO:0034383]; negative regulation of gene expression [GO:0010629]; phospholipid transport [GO:0015914]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001948; GO:0002020; GO:0005041; GO:0005509; GO:0005764; GO:0005768; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005905; GO:0006629; GO:0008203; GO:0009897; GO:0009986; GO:0010628; GO:0010629; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016021; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0034362; GO:0034383; GO:0042157; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0050729; GO:0070508; GO:0071398; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; P62845 CHOYP_RS15.1.1 m.5709 sp RS15_RAT 89.011 91 10 0 16 106 55 145 6.07E-57 175 RS15_RAT reviewed 40S ribosomal protein S15 (RIG protein) Rps15 Rig Rattus norvegicus (Rat) 145 liver regeneration [GO:0097421]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0005654; GO:0006412; GO:0022627; GO:0097421 0 0 0 PF00203; Q5RB02 CHOYP_BRAFLDRAFT_125840.1.1 m.58396 sp CATC_PONAB 53.968 441 197 3 13 448 21 460 6.07E-180 513 CATC_PONAB reviewed Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)] CTSC Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 463 0 GO:0005764; GO:0008234 0 0 0 PF08773;PF00112; Q6XKE6 CHOYP_contig_025803 m.29450 sp POLG_PVCV2 26.889 450 260 15 42 466 1400 1805 6.07E-23 108 POLG_PVCV2 reviewed Genome polyprotein [Cleaved into: Movement protein (MP); Capsid protein (CP); Aspartic protease (PR) (EC 3.4.23.-); Reverse transcriptase (RT) (EC 2.7.7.49)] 0 Petunia vein clearing virus (isolate Hohn) (PVCV) 2180 "transport of virus in host, cell to cell [GO:0046740]" GO:0003677; GO:0003964; GO:0004190; GO:0004519; GO:0008270; GO:0046740 0 0 0 PF01107;PF00078;PF00098; Q80ZA4 CHOYP_PKHD1L1.5.5 m.29972 sp PKHL1_MOUSE 32.915 319 191 7 10 307 805 1121 6.07E-41 155 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q9SR22 CHOYP_LOC100372731.1.1 m.59472 sp PAE5_ARATH 31.7 347 212 7 89 418 69 407 6.07E-51 181 PAE5_ARATH reviewed Pectin acetylesterase 5 (EC 3.1.1.-) PAE5 At3g09410 F3L24.31 Arabidopsis thaliana (Mouse-ear cress) 427 cell wall organization [GO:0071555] GO:0005576; GO:0005618; GO:0016787; GO:0071555 0 0 0 PF03283; Q9UPI3 CHOYP_FLVCR2B.1.1 m.48017 sp FLVC2_HUMAN 51.121 446 206 3 38 479 66 503 6.07E-157 459 FLVC2_HUMAN reviewed Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT) FLVCR2 C14orf58 Homo sapiens (Human) 526 transmembrane transport [GO:0055085] GO:0005886; GO:0015232; GO:0016021; GO:0020037; GO:0055085 0 0 cd06174; PF07690; A0JPI9 CHOYP_LOC100372392.4.8 m.31087 sp LR74A_RAT 37.17 417 256 4 103 514 51 466 6.08E-92 292 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; A4IF63 CHOYP_BRAFLDRAFT_169586.1.1 m.20664 sp TRIM2_BOVIN 23.026 152 113 3 39 187 593 743 6.08E-06 49.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E9FCP6 CHOYP_BRAFLDRAFT_77607.1.1 m.7988 sp DTXS3_METRA 44.262 122 68 0 3 124 140 261 6.08E-31 115 DTXS3_METRA reviewed Aldo-keto reductase dtxS3 (EC 1.1.1.-) (Destruxin synthesis protein 3) dtxS3 MAA_10045 Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23)) 370 0 GO:0016491 PATHWAY: Secondary metabolite biosynthesis. {ECO:0000269|PubMed:22232661}. 0 cd06660; PF00248; O60749 CHOYP_SNX2.1.1 m.25425 sp SNX2_HUMAN 49.071 538 229 9 27 538 1 519 6.08E-168 488 SNX2_HUMAN reviewed Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) SNX2 TRG9 Homo sapiens (Human) 519 "early endosome to Golgi transport [GO:0034498]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; lamellipodium morphogenesis [GO:0072673]; protein oligomerization [GO:0051259]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle organization [GO:0016050]" GO:0005154; GO:0005158; GO:0005737; GO:0005829; GO:0005913; GO:0006886; GO:0006897; GO:0010008; GO:0016020; GO:0016050; GO:0019898; GO:0030027; GO:0030904; GO:0030905; GO:0031901; GO:0034498; GO:0035091; GO:0042147; GO:0042803; GO:0043234; GO:0046982; GO:0051259; GO:0070062; GO:0072673; GO:0098641; GO:1990459; GO:1990460 0 0 0 PF00787;PF03700;PF09325; O75095 CHOYP_BRAFLDRAFT_282171.1.1 m.21613 sp MEGF6_HUMAN 39.496 119 66 4 158 276 863 975 6.08E-13 72.4 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O75179 CHOYP_LOC753709.26.44 m.46539 sp ANR17_HUMAN 34.676 447 274 10 160 595 250 689 6.08E-55 205 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75752 CHOYP_B3GN5.1.4 m.8695 sp B3GL1_HUMAN 23.431 239 150 6 55 279 51 270 6.08E-17 84 B3GL1_HUMAN reviewed "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)" B3GALNT1 B3GALT3 UNQ531/PRO1074 Homo sapiens (Human) 331 oligosaccharide biosynthetic process [GO:0009312]; protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008499; GO:0009312; GO:0016021; GO:0047273 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q13637 CHOYP_LOC100370154.2.2 m.65685 sp RAB32_HUMAN 70 210 59 2 19 228 20 225 6.08E-107 310 RAB32_HUMAN reviewed Ras-related protein Rab-32 RAB32 Homo sapiens (Human) 225 antigen processing and presentation [GO:0019882]; endosome to melanosome transport [GO:0035646]; melanosome assembly [GO:1903232]; phagosome maturation [GO:0090382]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005769; GO:0005783; GO:0005802; GO:0007264; GO:0016020; GO:0019882; GO:0030670; GO:0030742; GO:0035646; GO:0035650; GO:0035651; GO:0036461; GO:0042470; GO:0044233; GO:0045335; GO:0090382; GO:1903232 0 0 0 PF00071; Q196X6 CHOYP_BRAFLDRAFT_86475.2.2 m.54251 sp VF232_IIV3 33.758 157 81 6 324 470 579 722 6.08E-11 70.5 VF232_IIV3 reviewed Putative ubiquitin thioesterase 232R (EC 3.4.19.12) IIV3-084L Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) 844 "DNA-templated transcription, termination [GO:0006353]" GO:0006353; GO:0036459 0 0 0 PF02338;PF07498; Q5ND28 CHOYP_MEG11.9.25 m.40678 sp SREC_MOUSE 36.842 190 100 8 212 398 211 383 6.08E-21 99.8 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q61315 CHOYP_APC.2.2 m.39700 sp APC_MOUSE 47.368 437 179 7 84 509 114 510 6.08E-111 365 APC_MOUSE reviewed Adenomatous polyposis coli protein (Protein APC) (mAPC) Apc Mus musculus (Mouse) 2845 anterior/posterior pattern specification [GO:0009952]; axis specification [GO:0009798]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; canonical Wnt signaling pathway involved in positive regulation of apoptotic process [GO:0044337]; cell cycle arrest [GO:0007050]; cell fate specification [GO:0001708]; cell migration [GO:0016477]; cellular response to DNA damage stimulus [GO:0006974]; chromosome organization [GO:0051276]; cytoplasmic microtubule organization [GO:0031122]; dorsal/ventral pattern formation [GO:0009953]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; metaphase/anaphase transition of mitotic cell cycle [GO:0007091]; mitotic cytokinesis [GO:0000281]; mitotic spindle assembly checkpoint [GO:0007094]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of odontogenesis [GO:0042483]; negative regulation of Wnt signaling pathway [GO:0030178]; pattern specification process [GO:0007389]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of pseudopodium assembly [GO:0031274]; protein complex assembly [GO:0006461]; proximal/distal pattern formation [GO:0009954]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell migration [GO:0030334]; regulation of epithelial cell differentiation [GO:0030856]; regulation of microtubule-based process [GO:0032886]; regulation of nitrogen compound metabolic process [GO:0051171]; regulation of osteoblast differentiation [GO:0045667]; regulation of osteoclast differentiation [GO:0045670]; retina development in camera-type eye [GO:0060041]; skin development [GO:0043588]; somatic stem cell population maintenance [GO:0035019]; stem cell population maintenance [GO:0019827]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; Wnt signaling pathway [GO:0016055] GO:0000281; GO:0000776; GO:0001708; GO:0001822; GO:0001942; GO:0002020; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0005886; GO:0005912; GO:0005923; GO:0006461; GO:0006974; GO:0007026; GO:0007050; GO:0007091; GO:0007094; GO:0007389; GO:0007409; GO:0008013; GO:0008017; GO:0008285; GO:0009798; GO:0009952; GO:0009953; GO:0009954; GO:0016055; GO:0016328; GO:0016342; GO:0016477; GO:0019827; GO:0019887; GO:0019901; GO:0030027; GO:0030178; GO:0030334; GO:0030335; GO:0030424; GO:0030426; GO:0030856; GO:0030858; GO:0030877; GO:0031116; GO:0031122; GO:0031253; GO:0031274; GO:0032587; GO:0032886; GO:0033077; GO:0034750; GO:0035019; GO:0042483; GO:0042995; GO:0043065; GO:0043066; GO:0043409; GO:0043588; GO:0044295; GO:0044336; GO:0044337; GO:0045295; GO:0045595; GO:0045597; GO:0045667; GO:0045670; GO:0045732; GO:0045736; GO:0045785; GO:0046716; GO:0048538; GO:0050680; GO:0051010; GO:0051171; GO:0051276; GO:0051726; GO:0051781; GO:0051988; GO:0060041; GO:0060070; GO:0060770; GO:0090090 0 0 0 PF05972;PF05956;PF16689;PF05923;PF00514;PF05937;PF05924; Q66J54 CHOYP_LOC100001249.2.2 m.54527 sp S226A_XENLA 30.978 552 355 8 8 541 6 549 6.08E-84 274 S226A_XENLA reviewed Solute carrier family 22 member 6-A (Organic cation transporter 1-A) (Renal organic anion transporter 1-A) (ROAT1-A) slc22a6-a oat1-a Xenopus laevis (African clawed frog) 558 0 GO:0005886; GO:0016021; GO:0022857 0 0 cd06174; PF00083; Q6PBT7 CHOYP_LOC100560768.1.1 m.18804 sp TIM14_DANRE 57.759 116 48 1 1 116 1 115 6.08E-42 137 TIM14_DANRE reviewed Mitochondrial import inner membrane translocase subunit TIM14 (DnaJ homolog subfamily C member 19) dnajc19 tim14 timm14 zgc:73251 Danio rerio (Zebrafish) (Brachydanio rerio) 115 protein transport [GO:0015031] GO:0005743; GO:0015031; GO:0016021 0 0 cd06257; PF00226; Q80V03 CHOYP_ADCK5.1.2 m.11250 sp ADCK5_MOUSE 47.015 536 263 4 51 576 48 572 6.08E-161 475 ADCK5_MOUSE reviewed Uncharacterized aarF domain-containing protein kinase 5 (EC 2.7.11.-) Adck5 Mus musculus (Mouse) 582 0 GO:0004674; GO:0005739; GO:0016021 0 0 0 PF03109; Q8W4Q3 CHOYP_LOC100374769.1.1 m.40767 sp PIRL3_ARATH 32.907 313 198 6 75 376 80 391 6.08E-33 133 PIRL3_ARATH reviewed Plant intracellular Ras-group-related LRR protein 3 PIRL3 At1g12970 F13K23.23 Arabidopsis thaliana (Mouse-ear cress) 464 protein autophosphorylation [GO:0046777] GO:0004674; GO:0046777 0 0 0 PF00560;PF13855; Q921I2 CHOYP_LOC100115776.1.1 m.24729 sp KLDC4_MOUSE 43.212 604 287 15 14 611 15 568 6.08E-157 466 KLDC4_MOUSE reviewed Kelch domain-containing protein 4 Klhdc4 Mus musculus (Mouse) 584 0 0 0 0 0 PF07646; Q9BT25 CHOYP_LOC100121360.1.1 m.56330 sp HAUS8_HUMAN 35.135 111 72 0 463 573 169 279 6.08E-10 65.1 HAUS8_HUMAN reviewed HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) HAUS8 HICE1 Homo sapiens (Human) 410 cell division [GO:0051301]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0000086; GO:0000922; GO:0005813; GO:0005829; GO:0005874; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 0 Q9M146 CHOYP_BM1_44130.1.1 m.27713 sp MGP4_ARATH 23.469 294 182 11 71 339 80 355 6.08E-12 69.7 MGP4_ARATH reviewed "UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase MGP4 (EC 2.4.2.-) (Protein MALE GAMETOPHYTE DEFECTIVE 4) (Rhamnogalacturonan xylosyltransferase MGP4)" MGP4 At4g01220 F2N1.35 Arabidopsis thaliana (Mouse-ear cress) 360 pollen tube development [GO:0048868]; rhamnogalacturonan II biosynthetic process [GO:0010306] GO:0000139; GO:0005794; GO:0010306; GO:0016021; GO:0035252; GO:0042285; GO:0048868 0 0 0 PF03407; Q9UEW8 CHOYP_STK39.1.1 m.44512 sp STK39_HUMAN 63.441 93 33 1 1 92 453 545 6.08E-32 119 STK39_HUMAN reviewed STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39) STK39 SPAK Homo sapiens (Human) 545 cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; negative regulation of rubidium ion transport [GO:2000681]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of potassium ion transport [GO:0043268]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; regulation of ion homeostasis [GO:2000021]; response to stress [GO:0006950]; signal transduction by protein phosphorylation [GO:0023014] GO:0001933; GO:0004674; GO:0004702; GO:0005524; GO:0005634; GO:0005737; GO:0005856; GO:0006468; GO:0006950; GO:0008217; GO:0016323; GO:0016324; GO:0018105; GO:0018107; GO:0023014; GO:0035556; GO:0043268; GO:0050727; GO:0071476; GO:0090188; GO:1901017; GO:1901380; GO:2000021; GO:2000681; GO:2000687 0 0 0 PF12202;PF00069; A5D989 CHOYP_NUBP1.1.1 m.65723 sp EF1D_BOVIN 56.098 205 76 1 15 205 76 280 6.09E-70 217 EF1D_BOVIN reviewed Elongation factor 1-delta (EF-1-delta) EEF1D Bos taurus (Bovine) 280 cellular response to ionizing radiation [GO:0071479]; mRNA transcription [GO:0009299]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of cell death [GO:0010941] GO:0003677; GO:0003746; GO:0004871; GO:0005730; GO:0005783; GO:0005853; GO:0009299; GO:0010941; GO:0043123; GO:0071479 0 0 cd00292; PF10587;PF00736; O75382 CHOYP_BRAFLDRAFT_87322.8.10 m.64644 sp TRIM3_HUMAN 26.829 123 86 3 131 250 622 743 6.09E-06 50.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P38977 CHOYP_LOC100891949.3.4 m.28647 sp ANTA_HYDVU 26.556 241 121 11 140 361 5 208 6.09E-07 54.3 ANTA_HYDVU reviewed Antistasin (ATS) (Blood coagulation factor Xa/proclotting enzyme inhibitor) 0 Hydra vulgaris (Hydra) (Hydra attenuata) 220 blood coagulation [GO:0007596] GO:0004867; GO:0005576; GO:0007596; GO:0008201 0 0 0 PF02822; Q14BN4 CHOYP_SLMAP.6.8 m.36920 sp SLMAP_HUMAN 51.19 504 219 8 23 506 3 499 6.09E-148 462 SLMAP_HUMAN reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) 828 muscle contraction [GO:0006936] GO:0005790; GO:0005815; GO:0005887; GO:0006936; GO:0042383 0 0 0 PF00498; Q25074 CHOYP_AQP5.1.1 m.26714 sp AQP_HAEIX 56.667 60 23 1 69 128 190 246 6.09E-15 73.2 AQP_HAEIX reviewed Aquaporin (BfWC1) (Water channel 1) 0 Haematobia irritans exigua (Buffalo fly) 251 0 GO:0005215; GO:0016021 0 0 cd00333; PF00230; Q53G44 CHOYP_BRAFLDRAFT_99019.3.8 m.27353 sp IF44L_HUMAN 40.996 261 151 2 232 490 176 435 6.09E-53 188 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5SP85 CHOYP_CC85C.1.1 m.52139 sp CC85A_MOUSE 58.156 141 59 0 44 184 31 171 6.09E-52 190 CC85A_MOUSE reviewed Coiled-coil domain-containing protein 85A Ccdc85a Kiaa1912 Mus musculus (Mouse) 500 0 0 0 0 0 PF10226; Q6UXI7 CHOYP_LOC100210247.2.2 m.54227 sp VITRN_HUMAN 27.219 169 105 6 129 284 279 442 6.09E-10 63.9 VITRN_HUMAN reviewed Vitrin VIT UNQ647/PRO1277 Homo sapiens (Human) 678 extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0005539; GO:0005614; GO:0010811; GO:0030198 0 0 0 PF03815;PF00092; Q80V70 CHOYP_MEG10.58.91 m.48257 sp MEGF6_MOUSE 36.73 422 233 18 3 424 806 1193 6.09E-59 216 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8R151 CHOYP_LOC100372654.2.2 m.36698 sp ZNFX1_MOUSE 42.439 205 114 4 1 204 1212 1413 6.09E-47 168 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8WV28 CHOYP_PHUM_PHUM128460.1.7 m.3477 sp BLNK_HUMAN 29.68 219 116 8 454 656 254 450 6.09E-15 81.3 BLNK_HUMAN reviewed B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65) BLNK BASH SLP65 Homo sapiens (Human) 456 B cell differentiation [GO:0030183]; humoral immune response [GO:0006959]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556] GO:0005068; GO:0005070; GO:0005622; GO:0005737; GO:0005829; GO:0005886; GO:0006954; GO:0006959; GO:0030183; GO:0035556 0 0 0 PF00017; Q99996 CHOYP_LOC582174.16.16 m.64684 sp AKAP9_HUMAN 39.456 147 76 3 53 194 3587 3725 6.09E-22 96.3 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q99MG9 CHOYP_LOC100888051.2.3 m.9726 sp KCIP4_RAT 60.606 198 77 1 35 232 54 250 6.09E-92 273 KCIP4_RAT reviewed Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) Kcnip4 Kchip4 Rattus norvegicus (Rat) 250 protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379] GO:0005244; GO:0005267; GO:0005509; GO:0005829; GO:0005886; GO:0008076; GO:0015459; GO:0016020; GO:0030425; GO:0043025; GO:0072659; GO:1901379 0 0 0 PF13499;PF13833; Q9DBT3 CHOYP_LOC100370539.1.1 m.10562 sp CCD97_MOUSE 33.444 302 172 6 3 288 49 337 6.09E-33 127 CCD97_MOUSE reviewed Coiled-coil domain-containing protein 97 Ccdc97 D7Ertd462e Mus musculus (Mouse) 340 0 GO:0005686 0 0 0 PF09747; Q9H8W5 CHOYP_BRAFLDRAFT_82868.5.5 m.55659 sp TRI45_HUMAN 23.78 164 108 3 36 190 133 288 6.09E-09 61.2 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9U489 CHOYP_BRAFLDRAFT_84665.3.3 m.56688 sp LIN41_CAEEL 34.259 108 64 4 102 203 823 929 6.09E-06 52.8 LIN41_CAEEL reviewed Protein lin-41 (Abnormal cell lineage protein 41) lin-41 C12C8.3 Caenorhabditis elegans 1147 "epidermal cell fate specification [GO:0009957]; gamete generation [GO:0007276]; multicellular organismal protein metabolic process [GO:0044268]; nematode male tail tip morphogenesis [GO:0045138]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of development, heterochronic [GO:0040034]; regulation of epidermal cell differentiation [GO:0045604]" GO:0004842; GO:0005737; GO:0007276; GO:0008270; GO:0009957; GO:0040034; GO:0042787; GO:0044268; GO:0045138; GO:0045604 0 0 0 PF00630;PF01436; Q9Z1J2 CHOYP_NEK4.4.8 m.37069 sp NEK4_MOUSE 37.586 290 167 5 13 296 11 292 6.09E-56 205 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; A4IF63 CHOYP_TRIM2.33.59 m.37760 sp TRIM2_BOVIN 23.043 230 130 5 86 293 490 694 6.10E-09 60.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_TRIM3.6.58 m.5978 sp TRIM3_RAT 27.354 223 141 9 13 226 534 744 6.10E-12 67.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P20073 CHOYP_DVIR_GJ11008.1.1 m.11917 sp ANXA7_HUMAN 46.129 310 167 0 3 312 177 486 6.10E-95 292 ANXA7_HUMAN reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 SNX OK/SW-cl.95 Homo sapiens (Human) 488 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; membrane fusion [GO:0061025]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to calcium ion [GO:0051592]; response to organic cyclic compound [GO:0014070]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005178; GO:0005509; GO:0005544; GO:0005634; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0014070; GO:0016020; GO:0030855; GO:0035176; GO:0044822; GO:0048306; GO:0051592; GO:0061025; GO:0070062 0 0 0 PF00191; P23403 CHOYP_LOC100550844.5.7 m.18855 sp RS20_XENLA 90.217 92 7 2 4 93 3 94 6.10E-52 163 RS20_XENLA reviewed 40S ribosomal protein S20 (S22) rps20 Xenopus laevis (African clawed frog) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00338; P31241 CHOYP_MPI5.1.1 m.2885 sp MPI5_LYMST 27.642 123 59 3 39 159 43 137 6.10E-07 49.3 MPI5_LYMST reviewed Molluscan insulin-related peptide 5 (MIP V) [Cleaved into: Molluscan insulin-related peptide 5 B chain; Molluscan insulin-related peptide 5 A chain] 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 138 0 GO:0005576; GO:0030133 0 0 0 PF00049; P35448 CHOYP_LOC100888702.1.1 m.56287 sp TSP1_XENLA 64 50 18 0 350 399 438 487 6.10E-13 77 TSP1_XENLA reviewed Thrombospondin-1 thbs1 tsp1 Xenopus laevis (African clawed frog) 1173 cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; response to unfolded protein [GO:0006986] GO:0005509; GO:0005615; GO:0005783; GO:0006954; GO:0006986; GO:0007155; GO:0008201; GO:0016525; GO:0016529; GO:0050840 0 0 0 PF12947;PF00090;PF02412;PF05735;PF00093; P46209 CHOYP_NEMVEDRAFT_V1G164392.2.3 m.58236 sp USF_AQUPY 34.973 183 102 6 49 220 27 203 6.10E-24 99 USF_AQUPY reviewed Protein usf usf Aquifex pyrophilus 231 0 GO:0016787 0 0 0 PF01738; P97852 CHOYP_DHB4.2.2 m.19618 sp DHB4_RAT 76.316 304 72 0 1 304 7 310 6.10E-165 489 DHB4_RAT reviewed "Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MPF-2) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]" Hsd17b4 Edh17b4 Rattus norvegicus (Rat) 735 aging [GO:0007568]; cellular response to organic cyclic compound [GO:0071407]; cholesterol metabolic process [GO:0008203]; fatty acid beta-oxidation [GO:0006635]; response to drug [GO:0042493]; response to organic cyclic compound [GO:0014070]; response to steroid hormone [GO:0048545] GO:0004303; GO:0005777; GO:0006635; GO:0007568; GO:0008203; GO:0014070; GO:0016853; GO:0018812; GO:0030283; GO:0033989; GO:0042493; GO:0042803; GO:0044594; GO:0048545; GO:0071407 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00106;PF01575;PF02036; Q14162 CHOYP_SCARF1.1.7 m.15616 sp SREC_HUMAN 36 125 76 4 22 146 250 370 6.10E-15 75.1 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q19673 CHOYP_CRE_16884.1.1 m.28203 sp TYR3_CAEEL 33.138 341 195 13 106 424 108 437 6.10E-43 169 TYR3_CAEEL reviewed Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans 693 0 GO:0004497; GO:0046872 0 0 0 PF01549;PF00264; Q196X6 CHOYP_BRAFLDRAFT_86475.1.2 m.48519 sp VF232_IIV3 33.758 157 81 6 312 458 579 722 6.10E-11 70.5 VF232_IIV3 reviewed Putative ubiquitin thioesterase 232R (EC 3.4.19.12) IIV3-084L Invertebrate iridescent virus 3 (IIV-3) (Mosquito iridescent virus) 844 "DNA-templated transcription, termination [GO:0006353]" GO:0006353; GO:0036459 0 0 0 PF02338;PF07498; Q2TBI0 CHOYP_LOC589952.1.5 m.2235 sp LBP_BOVIN 24.797 246 180 3 2 245 236 478 6.10E-13 71.2 LBP_BOVIN reviewed Lipopolysaccharide-binding protein (LBP) LBP Bos taurus (Bovine) 481 acute-phase response [GO:0006953]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; macrophage activation involved in immune response [GO:0002281]; positive regulation of tumor necrosis factor production [GO:0032760] GO:0001530; GO:0002281; GO:0005615; GO:0006869; GO:0006953; GO:0016020; GO:0032760; GO:0045087; GO:0050829; GO:0071222 0 0 0 PF01273;PF02886; Q32KL8 CHOYP_LOC100377392.1.4 m.4798 sp TBATA_BOVIN 30.078 256 112 9 47 294 59 255 6.10E-22 99.4 TBATA_BOVIN reviewed "Protein TBATA (Protein SPATIAL) (Stromal protein associated with thymii and lymph node homolog) (Thymus, brain and testes-associated protein)" TBATA SPATIAL Bos taurus (Bovine) 333 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005829; GO:0007275; GO:0007283; GO:0030154 0 0 0 0 Q6IQY5 CHOYP_LOC100370976.1.2 m.17764 sp CEP70_MOUSE 29.094 629 380 14 54 670 41 615 6.10E-64 226 CEP70_MOUSE reviewed Centrosomal protein of 70 kDa (Cep70) Cep70 Mus musculus (Mouse) 616 0 GO:0005654; GO:0005737; GO:0005813; GO:0031965 0 0 0 0 Q86Y13 CHOYP_LOC100372716.6.10 m.32362 sp DZIP3_HUMAN 29.348 92 65 0 73 164 451 542 6.10E-06 49.3 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8C2A2 CHOYP_LOC100702975.1.1 m.18692 sp SEN54_MOUSE 30.672 551 333 15 16 560 16 523 6.10E-63 218 SEN54_MOUSE reviewed tRNA-splicing endonuclease subunit Sen54 (tRNA-intron endonuclease Sen54) Tsen54 Sen54 Mus musculus (Mouse) 525 "mRNA processing [GO:0006397]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]" GO:0000214; GO:0000379; GO:0005730; GO:0006388; GO:0006397; GO:0090502 0 0 0 PF12928; Q9Y6R7 CHOYP_BRAFLDRAFT_87842.1.1 m.35635 sp FCGBP_HUMAN 26.033 242 167 6 207 444 131 364 6.10E-15 81.6 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A8C754 CHOYP_LOC100536294.1.1 m.15947 sp THADA_CHICK 31.507 584 320 15 2 550 393 931 6.11E-74 259 THADA_CHICK reviewed Thyroid adenoma-associated protein homolog THADA Gallus gallus (Chicken) 1930 0 0 0 0 0 PF10350; O43301 CHOYP_HSPA12A.7.27 m.23290 sp HS12A_HUMAN 36.634 101 56 4 1 98 537 632 6.11E-10 58.2 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75179 CHOYP_LOC753709.14.44 m.25353 sp ANR17_HUMAN 34.991 543 298 17 128 655 222 724 6.11E-65 236 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P22451 CHOYP_LOC373275.7.7 m.63849 sp RL5_CHICK 79.918 244 49 0 16 259 5 248 6.11E-148 418 RL5_CHICK reviewed 60S ribosomal protein L5 RPL5 Gallus gallus (Chicken) 297 ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0005925; GO:0006364; GO:0006412; GO:0008097; GO:0016020; GO:0022625; GO:0044822; GO:0070062 0 0 0 PF14204;PF17144; P37805 CHOYP_TAGL3.1.1 m.31031 sp TAGL3_RAT 32.704 159 94 6 6 162 4 151 6.11E-11 61.6 TAGL3_RAT reviewed Transgelin-3 (Neuronal protein 22) (NP22) (Neuronal protein NP25) Tagln3 Np25 Rattus norvegicus (Rat) 199 0 0 0 0 0 PF00402;PF00307; P41413 CHOYP_GSPATT00032979001.1.1 m.56433 sp PCSK5_RAT 23.891 699 429 35 133 754 654 1326 6.11E-10 67 PCSK5_RAT reviewed Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (Subtilisin/kexin-like protease PC5) (rPC5) Pcsk5 Rattus norvegicus (Rat) 1809 anterior/posterior pattern specification [GO:0009952]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; cytokine biosynthetic process [GO:0042089]; determination of left/right symmetry [GO:0007368]; embryo implantation [GO:0007566]; embryonic digestive tract development [GO:0048566]; embryonic skeletal system development [GO:0048706]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; peptide biosynthetic process [GO:0043043]; peptide hormone processing [GO:0016486]; protein processing [GO:0016485]; renin secretion into blood stream [GO:0002001]; respiratory tube development [GO:0030323]; signal peptide processing [GO:0006465]; viral life cycle [GO:0019058] GO:0001822; GO:0002001; GO:0003279; GO:0004252; GO:0005615; GO:0005794; GO:0006465; GO:0007368; GO:0007566; GO:0009952; GO:0016021; GO:0016485; GO:0016486; GO:0019058; GO:0030141; GO:0030323; GO:0035108; GO:0042089; GO:0042277; GO:0043043; GO:0048566; GO:0048706; GO:0060976 0 0 0 PF14843;PF01483;PF00082;PF16470; P50876 CHOYP_BRAFLDRAFT_125022.1.1 m.43641 sp R144A_HUMAN 52.703 296 130 4 3 295 2 290 6.11E-106 313 R144A_HUMAN reviewed E3 ubiquitin-protein ligase RNF144A (EC 6.3.2.-) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4) RNF144A KIAA0161 RNF144 UBCE7IP4 Homo sapiens (Human) 292 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0000209; GO:0005794; GO:0005886; GO:0008270; GO:0016021; GO:0016874; GO:0030659; GO:0031624; GO:0032436; GO:0042787; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01485; P81116 CHOYP_C43H6.6.2.2 m.54235 sp SLBB_TRIAB 24.161 149 95 7 146 289 10 145 6.11E-07 52 SLBB_TRIAB reviewed Snaclec alboaggregin-B subunit beta (AL-B subunit beta) (25-kDa alboaggregin) 0 Trimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris) 146 0 GO:0005576 0 0 0 PF00059; P87132 CHOYP_LOC100178454.1.1 m.43716 sp YFK5_SCHPO 27.564 156 100 5 28 181 427 571 6.11E-09 57.8 YFK5_SCHPO reviewed Uncharacterized protein C167.05 SPAC167.05 SPAC57A7.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 601 response to stress [GO:0006950] GO:0005829; GO:0006950 0 0 0 PF00582; Q09654 CHOYP_LOC100369186.2.9 m.27904 sp TRI23_CAEEL 25 208 123 7 22 207 118 314 6.11E-07 54.7 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q13231 CHOYP_DYAK_GE26461.1.1 m.41494 sp CHIT1_HUMAN 34.118 170 83 5 1 169 324 465 6.11E-24 103 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q2F637 CHOYP_1433Z.1.1 m.17045 sp 1433Z_BOMMO 62.5 248 83 2 4 246 5 247 6.11E-107 313 1433Z_BOMMO reviewed 14-3-3 protein zeta 14-3-3zeta Bombyx mori (Silk moth) 247 0 GO:0005737 0 0 0 PF00244; Q3ZC15 CHOYP_LOC100902369.2.2 m.24413 sp RCAN2_BOVIN 47.283 184 81 3 36 206 9 189 6.11E-53 171 RCAN2_BOVIN reviewed Calcipressin-2 (Down syndrome candidate region 1-like 1) (Regulator of calcineurin 2) RCAN2 DSCR1L1 Bos taurus (Bovine) 197 calcium-mediated signaling [GO:0019722]; regulation of calcineurin-NFAT signaling cascade [GO:0070884] GO:0000166; GO:0005737; GO:0008597; GO:0019722; GO:0070884 0 0 0 PF04847; Q5TZ18 CHOYP_LOC100378522.1.2 m.6787 sp NAV3_DANRE 29.808 104 72 1 127 229 56 159 6.11E-08 61.2 NAV3_DANRE reviewed Neuron navigator 3 nav3 si:dkeyp-60g2.1 Danio rerio (Zebrafish) (Brachydanio rerio) 2269 liver morphogenesis [GO:0072576]; pancreas development [GO:0031016] GO:0003779; GO:0005524; GO:0005640; GO:0005794; GO:0030027; GO:0030175; GO:0031016; GO:0072576 0 0 0 PF00004;PF00307; Q64133 CHOYP_AOFA.1.1 m.25415 sp AOFA_MOUSE 45.631 515 265 6 5 506 12 524 6.11E-164 478 AOFA_MOUSE reviewed Amine oxidase [flavin-containing] A (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) Maoa Mus musculus (Mouse) 526 dopamine catabolic process [GO:0042420]; neurotransmitter catabolic process [GO:0042135]; phenylethylamine metabolic process [GO:0042443]; serotonin metabolic process [GO:0042428] GO:0005739; GO:0005741; GO:0008131; GO:0016021; GO:0042135; GO:0042420; GO:0042428; GO:0042443; GO:0050660; GO:0051378 0 0 0 PF01593; Q6NWC6 CHOYP_LOC100116878.1.1 m.11655 sp CPSF6_DANRE 60 175 52 7 331 499 352 514 6.11E-47 175 CPSF6_DANRE reviewed Cleavage and polyadenylation specificity factor subunit 6 cpsf6 Danio rerio (Zebrafish) (Brachydanio rerio) 545 mRNA polyadenylation [GO:0006378] GO:0000166; GO:0003729; GO:0005634; GO:0005849; GO:0006378 0 0 0 PF00076; Q6ZMY6 CHOYP_BRAFLDRAFT_126756.1.1 m.29611 sp WDR88_HUMAN 39.612 361 213 4 30 386 86 445 6.11E-94 292 WDR88_HUMAN reviewed WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein) WDR88 PQWD Homo sapiens (Human) 472 0 0 0 0 0 PF01011;PF00400; Q8K3A2 CHOYP_TRPT1.1.1 m.59684 sp TRPT1_MOUSE 42.365 203 107 6 3 196 21 222 6.11E-43 147 TRPT1_MOUSE reviewed tRNA 2'-phosphotransferase 1 (mTPT1) (EC 2.7.1.160) Trpt1 Tpt1h Mus musculus (Mouse) 249 "regulation of protein kinase activity [GO:0045859]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388; GO:0008665; GO:0045859 0 0 0 PF01885; Q961D9 CHOYP_LOC662357.1.1 m.64851 sp BCL9_DROME 53.448 58 26 1 147 204 316 372 6.11E-11 71.2 BCL9_DROME reviewed Protein BCL9 homolog (Protein legless) lgs BCL9 CG2041 Drosophila melanogaster (Fruit fly) 1469 "imaginal disc-derived wing margin morphogenesis [GO:0008587]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; segment polarity determination [GO:0007367]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0005634; GO:0006351; GO:0007367; GO:0008587; GO:0016055; GO:0030177; GO:0045944 0 0 0 PF11502; Q96P65 CHOYP_BRAFLDRAFT_202783.2.2 m.41804 sp QRFPR_HUMAN 30.595 353 211 9 32 369 9 342 6.11E-42 155 QRFPR_HUMAN reviewed Pyroglutamylated RFamide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) QRFPR GPR103 Homo sapiens (Human) 431 cellular response to hormone stimulus [GO:0032870]; G-protein coupled receptor signaling pathway [GO:0007186]; response to peptide [GO:1901652] GO:0004930; GO:0004983; GO:0005886; GO:0005887; GO:0007186; GO:0016021; GO:0032870; GO:0042277; GO:1901652 0 0 0 PF00001; Q9CPX9 CHOYP_APC11.1.1 m.40790 sp APC11_MOUSE 84.524 84 13 0 2 85 1 84 6.11E-50 155 APC11_MOUSE reviewed Anaphase-promoting complex subunit 11 (APC11) (Cyclosome subunit 11) Anapc11 Mus musculus (Mouse) 84 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0005680; GO:0005737; GO:0007067; GO:0008270; GO:0016567; GO:0034450; GO:0042787; GO:0045842; GO:0051301; GO:0061630; GO:0070979; GO:0097602 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12861; O01812 CHOYP_FABP6.2.2 m.59518 sp FABP6_CAEEL 29.545 132 89 2 5 134 3 132 6.12E-12 62.4 FABP6_CAEEL reviewed Fatty acid-binding protein homolog 6 lbp-6 W02D3.5 Caenorhabditis elegans 135 0 GO:0005215; GO:0008289 0 0 0 PF00061; P17178 CHOYP_NEMVEDRAFT_V1G102678.1.1 m.57500 sp CP27A_RAT 28.311 219 152 5 1 216 222 438 6.12E-22 96.3 CP27A_RAT reviewed "Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)" Cyp27a1 Cyp27 Rattus norvegicus (Rat) 533 cholesterol metabolic process [GO:0008203]; steroid catabolic process [GO:0006706] GO:0005506; GO:0005739; GO:0005740; GO:0006706; GO:0008203; GO:0016705; GO:0020037; GO:0030343; GO:0031073; GO:0031966 PATHWAY: Hormone biosynthesis; cholecalciferol biosynthesis. 0 0 PF00067; P42577 CHOYP_PTBP1.1.2 m.49 sp FRIS_LYMST 83.673 147 24 0 1 147 1 147 6.12E-90 262 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P94459 CHOYP_SLIP_0475.1.1 m.57121 sp PPSD_BACSU 25.045 551 323 23 23 550 1500 1983 6.12E-24 110 PPSD_BACSU reviewed Plipastatin synthase subunit D (EC 2.3.1.-) (Peptide synthase 4) [Includes: ATP-dependent proline adenylase (ProA 1) (Proline activase 1); ATP-dependent glutamine adenylase (GlnA) (Glutamine activase); ATP-dependent tyrosine adenylase 2 (TyrA 2) (Tyrosine activase 2)] ppsD pps4 BSU18310 Bacillus subtilis (strain 168) 3603 antibiotic biosynthetic process [GO:0017000] GO:0016740; GO:0017000; GO:0031177 0 0 0 PF00501;PF13193;PF00668;PF00550; Q03650 CHOYP_MAL13P1.313.2.2 m.41382 sp CRAM_TRYBB 28.924 567 384 14 183 744 63 615 6.12E-19 95.9 CRAM_TRYBB reviewed "Cysteine-rich, acidic integral membrane protein" CRAM Trypanosoma brucei brucei 945 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021; GO:0020016 0 0 0 PF07016; Q06852 CHOYP_DWIL_GK10515.4.4 m.60306 sp SLAP1_CLOTH 56.573 426 136 32 745 1133 1499 1912 6.12E-30 133 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q5T1B0 CHOYP_LOC578169.1.1 m.63470 sp AXDN1_HUMAN 33.46 1052 589 24 10 1026 7 982 6.12E-164 513 AXDN1_HUMAN reviewed Axonemal dynein light chain domain-containing protein 1 AXDND1 C1orf125 Homo sapiens (Human) 1012 0 0 0 0 0 PF10211; Q6AXU6 CHOYP_LOC101157371.2.3 m.50812 sp HN1_RAT 50 54 26 1 1 53 1 54 6.12E-06 47.8 HN1_RAT reviewed "Hematological and neurological expressed 1 protein [Cleaved into: Hematological and neurological expressed 1 protein, N-terminally processed]" Hn1 Rattus norvegicus (Rat) 149 0 GO:0005730; GO:0031965 0 0 0 PF17054; Q6H236 CHOYP_BACOIKO003_32.2.3 m.31690 sp PEG3_BOVIN 44.041 193 81 12 376 546 1260 1447 6.12E-10 66.2 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q7TPV2 CHOYP_LOC100372716.1.10 m.5310 sp DZIP3_MOUSE 28.07 114 73 2 30 143 409 513 6.12E-07 55.5 DZIP3_MOUSE reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) 1204 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8IXR9 CHOYP_LOC100893889.1.2 m.7738 sp CL056_HUMAN 35.556 360 219 6 447 799 268 621 6.12E-61 220 CL056_HUMAN reviewed Uncharacterized protein C12orf56 C12orf56 Homo sapiens (Human) 622 0 0 0 0 0 PF15087; Q8K561 CHOYP_SRAP.16.18 m.58654 sp OTOAN_MOUSE 28.462 260 179 5 1535 1791 841 1096 6.12E-20 100 OTOAN_MOUSE reviewed Otoancorin Otoa Mus musculus (Mouse) 1137 cell-matrix adhesion [GO:0007160]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226] GO:0005578; GO:0007160; GO:0007605; GO:0009986; GO:0016324; GO:0019226; GO:0031225 0 0 0 0 Q96H40 CHOYP_ZN486.1.1 m.29828 sp ZN486_HUMAN 56.757 111 48 0 14 124 318 428 6.12E-33 122 ZN486_HUMAN reviewed Zinc finger protein 486 (KRAB domain only protein 2) ZNF486 KRBO2 Homo sapiens (Human) 463 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0005634; GO:0006351; GO:0006355; GO:0046872; GO:0070062 0 0 cd07765; PF01352;PF00096;PF13912; Q9DEN3 CHOYP_FOXD3.1.1 m.29766 sp FXD3B_XENLA 51.037 241 86 6 69 278 20 259 6.12E-64 213 FXD3B_XENLA reviewed Forkhead box protein D3-B (FoxD3-B) (FoxD3b) (Fork head domain-related protein 6') (xFD-6') foxd3-b foxd3b Xenopus laevis (African clawed frog) 371 "negative regulation of neurogenesis [GO:0050768]; negative regulation of transcription, DNA-templated [GO:0045892]; neural crest cell fate commitment [GO:0014034]; positive regulation of neurogenesis [GO:0050769]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0014034; GO:0043565; GO:0045892; GO:0050768; GO:0050769 0 0 0 PF00250; Q9MYX8 CHOYP_LOC583995.1.2 m.23065 sp TAU_PAPHA 35.583 163 92 5 126 284 201 354 6.12E-18 89 TAU_PAPHA reviewed Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) MAPT TAU Papio hamadryas (Hamadryas baboon) 383 0 GO:0005829; GO:0005874; GO:0005886; GO:0030424 0 0 0 PF00418; A4IF63 CHOYP_BRAFLDRAFT_206799.12.23 m.39267 sp TRIM2_BOVIN 25.874 143 105 1 8 150 602 743 6.13E-10 60.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43614 CHOYP_OX2R.3.3 m.44161 sp OX2R_HUMAN 25.916 382 239 15 4 367 30 385 6.13E-13 73.2 OX2R_HUMAN reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Homo sapiens (Human) 444 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005886; GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; O75897 CHOYP_ST1C4.1.3 m.1687 sp ST1C4_HUMAN 37.895 285 144 12 30 299 35 301 6.13E-46 160 ST1C4_HUMAN reviewed Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) 302 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; sulfation [GO:0051923] GO:0004062; GO:0005829; GO:0008146; GO:0050427; GO:0051923 0 0 0 PF00685; Q14B02 CHOYP_RN133.1.1 m.51022 sp RN133_MOUSE 28.926 121 80 3 16 133 256 373 6.13E-08 57 RN133_MOUSE reviewed E3 ubiquitin-protein ligase RNF133 (EC 6.3.2.-) (Goliath-related E3 ubiquitin-protein ligase 2) (RING finger protein 133) Rnf133 Greul2 Mus musculus (Mouse) 382 protein autoubiquitination [GO:0051865] GO:0005789; GO:0008270; GO:0016021; GO:0016874; GO:0051865 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02225;PF13639; Q3V1N1 CHOYP_MFHA1.1.1 m.20348 sp MFHA1_MOUSE 23.96 697 437 22 30 688 99 740 6.13E-34 145 MFHA1_MOUSE reviewed Malignant fibrous histiocytoma-amplified sequence 1 homolog Mfhas1 Mus musculus (Mouse) 1048 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF13855;PF08477; Q3ZBH3 CHOYP_LOC751836.1.6 m.9820 sp CD151_BOVIN 25.126 199 138 3 66 264 61 248 6.13E-10 61.6 CD151_BOVIN reviewed CD151 antigen (CD antigen CD151) CD151 Bos taurus (Bovine) 253 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q6GLZ8 CHOYP_PHUM_PHUM335250.2.2 m.55353 sp SNR27_XENLA 50 92 44 2 84 174 68 158 6.13E-25 97.4 SNR27_XENLA reviewed U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (U4/U6.U5 snRNP 27 kDa protein) (U4/U6.U5-27K) (U4/U6.U5 tri-snRNP-associated protein 3) snrnp27 Xenopus laevis (African clawed frog) 158 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005634; GO:0006397; GO:0008380 0 0 0 PF08648; Q8N2E2 CHOYP_VWDE.2.13 m.22479 sp VWDE_HUMAN 26.359 368 243 12 669 1017 749 1107 6.13E-22 106 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q96MM6 CHOYP_LOC100207121.5.9 m.48175 sp HS12B_HUMAN 28.436 633 380 14 815 1383 61 684 6.13E-76 270 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BXB1 CHOYP_LGR4.1.2 m.27343 sp LGR4_HUMAN 29.596 223 126 5 186 406 60 253 6.13E-15 81.3 LGR4_HUMAN reviewed Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48) LGR4 GPR48 Homo sapiens (Human) 951 "bone mineralization [GO:0030282]; bone remodeling [GO:0046849]; canonical Wnt signaling pathway involved in metanephric kidney development [GO:0061290]; cell differentiation involved in metanephros development [GO:0072202]; circadian regulation of gene expression [GO:0032922]; digestive tract development [GO:0048565]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; hair follicle development [GO:0001942]; innate immune response [GO:0045087]; intestinal stem cell homeostasis [GO:0036335]; male genitalia development [GO:0030539]; metanephric glomerulus development [GO:0072224]; metanephric nephron tubule morphogenesis [GO:0072282]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of transcription, DNA-templated [GO:0045892]; osteoblast differentiation [GO:0001649]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription, DNA-templated [GO:0045893]; spermatogenesis [GO:0007283]" GO:0001649; GO:0001942; GO:0004888; GO:0004930; GO:0005886; GO:0005887; GO:0007283; GO:0030282; GO:0030539; GO:0032922; GO:0034122; GO:0036335; GO:0045087; GO:0045892; GO:0045893; GO:0046849; GO:0048565; GO:0050710; GO:0061290; GO:0072202; GO:0072224; GO:0072282; GO:0090190; GO:0090263; GO:2001013 0 0 0 PF00001;PF13855;PF01462; Q9UKA2 CHOYP_BRAFLDRAFT_58172.1.1 m.61764 sp FBXL4_HUMAN 43.229 576 312 8 29 598 53 619 6.13E-162 479 FBXL4_HUMAN reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) FBXL4 FBL4 FBL5 Homo sapiens (Human) 621 protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000209; GO:0004842; GO:0005654; GO:0005758; GO:0005829; GO:0006511 0 0 0 PF00646; Q9VI93 CHOYP_LOC659822.1.1 m.60908 sp RN_DROME 71.264 174 49 1 85 258 486 658 6.13E-85 281 RN_DROME reviewed Zinc finger protein rotund (Zinc finger protein roughened eye) rn roe CG32466 Drosophila melanogaster (Fruit fly) 946 "cell fate specification [GO:0001708]; chaeta development [GO:0022416]; compound eye development [GO:0048749]; imaginal disc-derived leg morphogenesis [GO:0007480]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; sensory perception of pain [GO:0019233]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001708; GO:0003676; GO:0003705; GO:0005634; GO:0006351; GO:0007480; GO:0019233; GO:0022416; GO:0045892; GO:0046872; GO:0048749 0 0 0 PF00096; A3KN46 CHOYP_DMOJ_GI12418.1.1 m.49398 sp LTMD1_BOVIN 22.83 311 189 9 60 340 71 360 6.14E-09 60.5 LTMD1_BOVIN reviewed LETM1 domain-containing protein 1 LETMD1 Bos taurus (Bovine) 360 0 GO:0005741; GO:0016021; GO:0043022 0 0 0 PF07766; A6NGN9 CHOYP_LOC100707926.2.4 m.43942 sp IGLO5_HUMAN 30.882 136 78 5 149 284 135 254 6.14E-09 60.1 IGLO5_HUMAN reviewed IgLON family member 5 IGLON5 Homo sapiens (Human) 336 0 GO:0005576 0 0 0 PF00047; B4PEU8 CHOYP_RS9.11.13 m.49921 sp RS9_DROYA 87.151 179 23 0 3 181 4 182 6.14E-111 317 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; O01393 CHOYP_LOC100533354.1.6 m.12794 sp UNC9_CAEEL 34.771 371 225 5 21 387 19 376 6.14E-75 241 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O01814 CHOYP_DANA_GF16638.1.1 m.10255 sp FABP5_CAEEL 40.741 135 76 3 3 137 5 135 6.14E-25 95.5 FABP5_CAEEL reviewed Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans 136 0 GO:0005215; GO:0005504; GO:0005634; GO:0048471 0 0 0 PF00061; O35127 CHOYP_LOC101357837.1.1 m.42114 sp C10_MOUSE 45.794 107 58 0 12 118 11 117 6.14E-29 105 C10_MOUSE reviewed Protein C10 Grcc10 C10 Mus musculus (Mouse) 126 0 GO:0005737 0 0 0 PF14974; P04323 CHOYP_contig_014017 m.15976 sp POL3_DROME 36.177 586 346 11 220 795 83 650 6.14E-100 345 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P18754 CHOYP_LOC754700.2.2 m.19480 sp RCC1_HUMAN 50.926 324 147 6 21 336 20 339 6.14E-104 316 RCC1_HUMAN reviewed Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1) RCC1 CHC1 Homo sapiens (Human) 421 cell division [GO:0051301]; chromosome segregation [GO:0007059]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]; viral process [GO:0016032] GO:0000082; GO:0000790; GO:0000794; GO:0003682; GO:0005087; GO:0005634; GO:0005654; GO:0005737; GO:0007052; GO:0007059; GO:0007067; GO:0007088; GO:0016032; GO:0031492; GO:0031965; GO:0042393; GO:0051225; GO:0051301 0 0 0 PF00415; P22105 CHOYP_LOC575944.3.5 m.24887 sp TENX_HUMAN 29.195 596 285 47 221 748 154 680 6.14E-34 144 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P25107 CHOYP_PTH1R.3.4 m.50190 sp PTH1R_DIDVI 38.952 439 239 11 33 452 66 494 6.14E-88 284 PTH1R_DIDVI reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) 585 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166] GO:0004991; GO:0005887; GO:0007166; GO:0007188; GO:0017046; GO:0043621 0 0 0 PF00002;PF02793; P35992 CHOYP_PTP10.1.3 m.17771 sp PTP10_DROME 43.564 303 160 5 814 1115 1241 1533 6.14E-72 268 PTP10_DROME reviewed Tyrosine-protein phosphatase 10D (EC 3.1.3.48) (Receptor-linked protein-tyrosine phosphatase 10D) (DPTP10D) Ptp10D CG1817 Drosophila melanogaster (Fruit fly) 1990 axon guidance [GO:0007411]; central nervous system development [GO:0007417]; long-term memory [GO:0007616]; motor neuron axon guidance [GO:0008045]; open tracheal system development [GO:0007424]; protein dephosphorylation [GO:0006470] GO:0004721; GO:0004725; GO:0005001; GO:0005886; GO:0006470; GO:0007411; GO:0007417; GO:0007424; GO:0007616; GO:0008045; GO:0016021; GO:0030424; GO:0045177 0 0 0 PF00041;PF00102; P57103 CHOYP_LOC100371845.1.3 m.14690 sp NAC3_HUMAN 35.307 895 455 19 25 823 54 920 6.14E-159 490 NAC3_HUMAN reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) SLC8A3 NCX3 Homo sapiens (Human) 927 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; ion transport [GO:0006811]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005886; GO:0005887; GO:0006811; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0016528; GO:0021537; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1903779; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; P80109 CHOYP_LOC590298.3.3 m.63121 sp PHLD_BOVIN 28.402 169 106 5 2 158 576 741 6.14E-13 69.7 PHLD_BOVIN reviewed Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) 839 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytolysis [GO:0045919]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633] GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0005578; GO:0005615; GO:0005737; GO:0006507; GO:0008285; GO:0008286; GO:0009749; GO:0010595; GO:0010694; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0032869; GO:0034364; GO:0035690; GO:0035774; GO:0043065; GO:0043231; GO:0045919; GO:0046470; GO:0051044; GO:0051047; GO:0070633; GO:0071277; GO:0071397; GO:0071401; GO:0071467; GO:1900076 0 0 0 PF01839;PF00882; P98109 CHOYP_LYAM3.2.4 m.3333 sp LYAM3_SHEEP 25.89 309 214 9 40 346 282 577 6.14E-18 88.6 LYAM3_SHEEP reviewed P-selectin (CD62 antigen-like family member P) (CD62P antigen) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62) SELP Ovis aries (Sheep) 769 cell adhesion [GO:0007155] GO:0007155; GO:0016021; GO:0030246 0 0 0 PF00059;PF00084; Q0IH24 CHOYP_SPEF1.2.4 m.22717 sp SPEF1_XENLA 42.248 258 114 5 12 268 3 226 6.14E-53 175 SPEF1_XENLA reviewed Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) 229 0 GO:0005737; GO:0005930 0 0 0 PF06294; Q496A3 CHOYP_LOC100374662.6.6 m.50717 sp SPAS1_HUMAN 39.759 83 42 2 107 183 142 222 6.14E-06 48.5 SPAS1_HUMAN reviewed Spermatogenesis-associated serine-rich protein 1 SPATS1 Homo sapiens (Human) 300 0 0 0 0 0 PF15160; Q5DU00 CHOYP_LOC100376412.1.3 m.13631 sp DCDC2_MOUSE 29.156 391 229 12 24 400 18 374 6.14E-35 141 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q5EE04 CHOYP_TPR.1.2 m.29645 sp TPR_XENLA 41.818 165 71 9 81 239 1739 1884 6.14E-21 99 TPR_XENLA reviewed Nucleoprotein TPR (NPC-associated intranuclear protein) (Translocated promoter region and nuclear basket protein) (Fragment) tpr Xenopus laevis (African clawed frog) 1997 cell division [GO:0051301]; cellular response to heat [GO:0034605]; MAPK import into nucleus [GO:0000189]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of translational initiation [GO:0045947]; positive regulation of heterochromatin assembly [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404] GO:0000122; GO:0000189; GO:0000776; GO:0003682; GO:0003729; GO:0005487; GO:0005643; GO:0005737; GO:0005868; GO:0006404; GO:0006405; GO:0007067; GO:0007094; GO:0010965; GO:0019898; GO:0031072; GO:0031453; GO:0031965; GO:0031990; GO:0034399; GO:0034605; GO:0042307; GO:0042405; GO:0042803; GO:0044615; GO:0045947; GO:0046827; GO:0046832; GO:0051019; GO:0051301; GO:0070849; GO:0072686; GO:0090267; GO:0090316; GO:1901673 0 0 0 PF07926; Q6H236 CHOYP_CPIPJ_CPIJ000460.1.2 m.34476 sp PEG3_BOVIN 32.155 283 183 1 1 283 1255 1528 6.14E-22 100 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6PDJ1 CHOYP_NEMVEDRAFT_V1G238894.5.11 m.55221 sp CAHD1_MOUSE 25.678 1106 731 40 26 1066 59 1138 6.14E-88 313 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6ZRF8 CHOYP_LOC100372879.2.3 m.21260 sp RN207_HUMAN 21.393 201 142 7 22 217 98 287 6.14E-08 58.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8C0Y1 CHOYP_LOC100901362.1.1 m.9856 sp TGIF2_MOUSE 40.724 221 85 7 24 213 3 208 6.14E-41 142 TGIF2_MOUSE reviewed Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2) Tgif2 Mus musculus (Mouse) 237 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nodal signaling pathway [GO:0038092]; positive regulation of neuron differentiation [GO:0045666]; regulation of gastrulation [GO:0010470]; retina development in camera-type eye [GO:0060041]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005654; GO:0006351; GO:0010470; GO:0038092; GO:0045666; GO:0060041 0 0 0 PF05920; Q8IYB1 CHOYP_NEMVEDRAFT_V1G199927.3.9 m.38771 sp M21D2_HUMAN 25 208 122 7 190 388 244 426 6.14E-08 58.2 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q9CZA6 CHOYP_NDL1A.1.1 m.10230 sp NDE1_MOUSE 56.774 310 102 5 2 298 3 293 6.14E-100 300 NDE1_MOUSE reviewed Nuclear distribution protein nudE homolog 1 (NudE) (mNudE) Nde1 Nude Mus musculus (Mouse) 344 cell division [GO:0051301]; centrosome duplication [GO:0051298]; centrosome localization [GO:0051642]; cerebral cortex development [GO:0021987]; chromosome segregation [GO:0007059]; establishment of chromosome localization [GO:0051303]; establishment of mitotic spindle orientation [GO:0000132]; forebrain development [GO:0030900]; microtubule nucleation [GO:0007020]; microtubule organizing center organization [GO:0031023]; mitotic centrosome separation [GO:0007100]; neuroblast proliferation [GO:0007405]; neuron migration [GO:0001764]; regulation of microtubule motor activity [GO:2000574]; vesicle transport along microtubule [GO:0047496] GO:0000132; GO:0000776; GO:0000777; GO:0001764; GO:0005737; GO:0005813; GO:0005815; GO:0005819; GO:0005871; GO:0005874; GO:0007020; GO:0007059; GO:0007100; GO:0007405; GO:0008017; GO:0016020; GO:0021987; GO:0030900; GO:0031023; GO:0031616; GO:0032154; GO:0042802; GO:0045202; GO:0047496; GO:0051298; GO:0051301; GO:0051303; GO:0051642; GO:2000574 0 0 0 PF04880; Q9UJV3 CHOYP_NEMVEDRAFT_V1G217091.3.4 m.52630 sp TRIM1_HUMAN 25.191 262 158 7 2 238 18 266 6.14E-16 84.7 TRIM1_HUMAN reviewed Probable E3 ubiquitin-protein ligase MID2 (EC 6.3.2.-) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (Tripartite motif-containing protein 1) MID2 FXY2 RNF60 TRIM1 Homo sapiens (Human) 735 innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567] GO:0005737; GO:0005874; GO:0008017; GO:0008270; GO:0010508; GO:0016567; GO:0016874; GO:0032897; GO:0035372; GO:0042803; GO:0043123; GO:0045087; GO:0046597; GO:0046982; GO:0051091; GO:0051092; GO:0051219; GO:0070062; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622;PF00643;PF13445; Q9VAU9 CHOYP_ZN330.1.2 m.7843 sp ZN330_DROME 66.393 244 82 0 18 261 3 246 6.14E-118 347 ZN330_DROME reviewed Zinc finger protein 330 homolog (Nucleolar autoantigen 36 homolog) Noa36 CG10009 Drosophila melanogaster (Fruit fly) 315 larval lymph gland hemopoiesis [GO:0035167] GO:0000775; GO:0005730; GO:0008270; GO:0030496; GO:0035167 0 0 0 PF06524; A0JPI9 CHOYP_NEMVEDRAFT_V1G245744.1.1 m.36806 sp LR74A_RAT 27.88 434 304 4 287 718 53 479 6.15E-45 172 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; B1AXV0 CHOYP_BRAFLDRAFT_140619.1.1 m.43486 sp FRS1L_MOUSE 26.54 211 131 10 200 403 97 290 6.15E-14 75.1 FRS1L_MOUSE reviewed DOMON domain-containing protein FRRS1L (Ferric-chelate reductase 1-like protein) Frrs1l Mus musculus (Mouse) 293 0 GO:0005886; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF03351; O35613 CHOYP_LRRX1.2.11 m.7800 sp DAXX_MOUSE 39.713 209 118 3 674 877 186 391 6.15E-41 166 DAXX_MOUSE reviewed Death domain-associated protein 6 (Daxx) Daxx Mus musculus (Mouse) 739 "androgen receptor signaling pathway [GO:0030521]; apoptotic signaling pathway [GO:0097190]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome assembly [GO:0006334]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron death [GO:1901216]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of multicellular organism growth [GO:0040014]; regulation of protein ubiquitination [GO:0031396]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000281; GO:0000775; GO:0000792; GO:0001934; GO:0002039; GO:0003713; GO:0003714; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0006334; GO:0006338; GO:0006351; GO:0006355; GO:0008134; GO:0016569; GO:0016605; GO:0019899; GO:0019901; GO:0030295; GO:0030521; GO:0031396; GO:0031625; GO:0040014; GO:0042393; GO:0042803; GO:0043066; GO:0045860; GO:0045892; GO:0045944; GO:0047485; GO:0050681; GO:0070603; GO:0097190; GO:1901216; GO:2001235 0 0 cd13151; PF03344; O54926 CHOYP_LOC100892743.1.1 m.55850 sp SIVA_MOUSE 32.813 192 105 6 1 189 1 171 6.15E-22 90.5 SIVA_MOUSE reviewed Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP) Siva1 Siva Mus musculus (Mouse) 175 extrinsic apoptotic signaling pathway [GO:0097191] GO:0001618; GO:0005164; GO:0005175; GO:0005654; GO:0005737; GO:0046872; GO:0097191 0 0 0 PF05458; P28827 CHOYP_PTPRK.7.20 m.8293 sp PTPRM_HUMAN 34.609 575 361 10 431 994 880 1450 6.15E-100 347 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P51989 CHOYP_LOC100748395.7.7 m.62091 sp RO21_XENLA 49.618 131 66 0 2 132 63 193 6.15E-34 129 RO21_XENLA reviewed Heterogeneous nuclear ribonucleoprotein A2 homolog 1 (hnRNP A2(A)) 0 Xenopus laevis (African clawed frog) 346 0 GO:0000166; GO:0003723; GO:0005634; GO:0030529 0 0 0 PF00076; Q2YDN4 CHOYP_LOC100371590.1.1 m.64405 sp CC105_BOVIN 30.376 372 243 4 45 414 110 467 6.15E-42 157 CC105_BOVIN reviewed Coiled-coil domain-containing protein 105 CCDC105 Bos taurus (Bovine) 500 0 GO:0070062 0 0 0 0 Q39565 CHOYP_BRAFLDRAFT_108792.1.5 m.21494 sp DYHB_CHLRE 26.786 1400 909 30 1211 2591 2169 3471 6.15E-155 549 DYHB_CHLRE reviewed "Dynein beta chain, flagellar outer arm" ODA4 ODA-4 SUP1 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4568 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0030030; GO:0030286; GO:0031514 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q54JW9 CHOYP_LOC101162891.1.1 m.36536 sp IMPCT_DICDI 39.56 91 54 1 291 381 209 298 6.15E-13 72.8 IMPCT_DICDI reviewed Protein IMPACT homolog impact DDB_G0287757 Dictyostelium discoideum (Slime mold) 345 cell differentiation [GO:0030154]; cellular response to acidic pH [GO:0071468]; cellular response to amino acid starvation [GO:0034198]; cellular response to benomyl [GO:0072755]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of cell death [GO:0060548]; nervous system development [GO:0007399]; regulation of translation [GO:0006417] GO:0005737; GO:0006417; GO:0007399; GO:0030154; GO:0034198; GO:0060548; GO:0070301; GO:0071468; GO:0072755 0 0 0 PF05773;PF01205; Q640V3 CHOYP_BRAFLDRAFT_203117.1.1 m.61688 sp NOL12_XENTR 39.2 125 66 2 3 119 1 123 6.15E-17 79 NOL12_XENTR reviewed Nucleolar protein 12 nol12 TNeu122o09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 216 0 GO:0005730; GO:0019843 0 0 0 PF09805; Q80V70 CHOYP_LOC579946.16.24 m.50660 sp MEGF6_MOUSE 37.255 510 288 19 12 514 708 1192 6.15E-65 232 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8R4G9 CHOYP_ACHA9.3.3 m.53227 sp ACHA3_MOUSE 31.268 339 219 5 4 339 65 392 6.15E-55 191 ACHA3_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-3 Chrna3 Mus musculus (Mouse) 499 "activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; behavioral response to nicotine [GO:0035095]; excitatory postsynaptic potential [GO:0060079]; locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of muscle contraction [GO:0006937]; regulation of smooth muscle contraction [GO:0006940]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0006937; GO:0006940; GO:0007165; GO:0007171; GO:0007271; GO:0007399; GO:0007626; GO:0014056; GO:0015464; GO:0030054; GO:0035095; GO:0042391; GO:0045211; GO:0048814; GO:0060079; GO:0060084 0 0 0 PF02931;PF02932; Q9BY84 CHOYP_BRAFLDRAFT_222288.1.1 m.27052 sp DUS16_HUMAN 53.401 294 128 3 52 343 15 301 6.15E-98 328 DUS16_HUMAN reviewed Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) DUSP16 KIAA1700 MKP7 Homo sapiens (Human) 665 "dephosphorylation [GO:0016311]; inactivation of MAPK activity [GO:0000188]; MAPK export from nucleus [GO:0045204]; MAPK phosphatase export from nucleus, leptomycin B sensitive [GO:0045209]" GO:0000188; GO:0004721; GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016023; GO:0016311; GO:0016791; GO:0017017; GO:0045204; GO:0045209 0 0 0 PF00782;PF00581; A6QLH5 CHOYP_CHRO_0413.1.2 m.16023 sp ERI3_BOVIN 53.636 220 94 5 12 225 116 333 6.16E-74 230 ERI3_BOVIN reviewed ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein) ERI3 PINT1 PRNPIP PRNPIP1 Bos taurus (Bovine) 337 "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" GO:0000467; GO:0004527; GO:0044822; GO:0046872 0 0 0 PF00929; P04069 CHOYP_MF-CPA.1.1 m.3630 sp CBPB_ASTAS 45.27 296 153 6 117 408 5 295 6.16E-90 278 CBPB_ASTAS reviewed Carboxypeptidase B (EC 3.4.17.2) 0 Astacus astacus (Noble crayfish) (Astacus fluviatilis) 303 0 GO:0004181; GO:0005576; GO:0008270 0 0 0 PF00246; P53804 CHOYP_TTC3.1.1 m.7750 sp TTC3_HUMAN 32 300 197 4 2 299 496 790 6.16E-36 148 TTC3_HUMAN reviewed E3 ubiquitin-protein ligase TTC3 (EC 6.3.2.-) (Protein DCRR1) (RING finger protein 105) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3) TTC3 DCRR1 RNF105 TPRD Homo sapiens (Human) 2025 protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004842; GO:0005634; GO:0005730; GO:0005737; GO:0006511; GO:0008270; GO:0016874; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; P61227 CHOYP_LOC100168751.1.1 m.49841 sp RAP2B_RAT 73.224 183 47 1 1 181 1 183 6.16E-87 256 RAP2B_RAT reviewed Ras-related protein Rap-2b Rap2b Rattus norvegicus (Rat) 183 negative regulation of cell migration [GO:0030336]; platelet aggregation [GO:0070527]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of protein tyrosine kinase activity [GO:0061097] GO:0005525; GO:0005829; GO:0005886; GO:0005923; GO:0019003; GO:0030336; GO:0031954; GO:0032486; GO:0044291; GO:0045121; GO:0055038; GO:0061097; GO:0070062; GO:0070527 0 0 0 PF00071; Q06805 CHOYP_LOC100701872.3.7 m.31772 sp TIE1_BOVIN 30.636 173 100 7 148 308 185 349 6.16E-16 82 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q08174 CHOYP_PCDH1.1.3 m.8001 sp PCDH1_HUMAN 32.867 715 439 15 78 761 111 815 6.16E-108 363 PCDH1_HUMAN reviewed Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42) PCDH1 Homo sapiens (Human) 1060 cell-cell signaling [GO:0007267]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399] GO:0005509; GO:0005886; GO:0005887; GO:0005911; GO:0007156; GO:0007267; GO:0007399 0 0 0 PF00028;PF08266;PF08374; Q4ZJM9 CHOYP_C1QL4.5.10 m.28345 sp C1QL4_MOUSE 34.127 126 75 3 254 371 110 235 6.16E-12 68.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5XNS0 CHOYP_EOMES.1.1 m.52466 sp TBX19_CANLF 28.395 162 68 2 1 114 61 222 6.16E-16 79.3 TBX19_CANLF reviewed T-box transcription factor TBX19 (T-box protein 19) TBX19 Canis lupus familiaris (Dog) (Canis familiaris) 445 "cell fate commitment [GO:0045165]; pituitary gland development [GO:0021983]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell differentiation [GO:0045595]; regulation of cell proliferation [GO:0042127]; transcription, DNA-templated [GO:0006351]" GO:0001158; GO:0003700; GO:0005634; GO:0006351; GO:0021983; GO:0042127; GO:0045165; GO:0045595; GO:0045944 0 0 0 PF00907; Q6PFY8 CHOYP_BRAFLDRAFT_75787.3.5 m.32932 sp TRI45_MOUSE 27.523 218 152 3 5 217 127 343 6.16E-13 70.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q7Z0T3 CHOYP_ACDOPBH.5.9 m.42992 sp TEMPT_APLCA 50.943 106 51 1 19 123 15 120 6.16E-28 111 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q8D3M4 CHOYP_BRAFLDRAFT_77063.1.1 m.8252 sp PHNW_VIBVU 47.514 362 184 5 42 401 3 360 6.16E-116 345 PHNW_VIBVU reviewed 2-aminoethylphosphonate--pyruvate transaminase (EC 2.6.1.37) (2-aminoethylphosphonate aminotransferase) (AEP transaminase) (AEPT) phnW VV2_1664 Vibrio vulnificus (strain CMCP6) 367 organic phosphonate catabolic process [GO:0019700] GO:0019700; GO:0047304 0 0 0 PF00266; Q8HYN0 CHOYP_LOC581885.1.1 m.45949 sp CP17A_PAPCY 33.333 141 92 2 83 221 20 160 6.16E-19 88.6 CP17A_PAPCY reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Papio cynocephalus (Yellow baboon) 508 hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0008202; GO:0016020; GO:0020037; GO:0042446; GO:0042448; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q9NZS9 CHOYP_BFAR.2.2 m.48768 sp BFAR_HUMAN 33.882 425 251 7 22 429 30 441 6.16E-86 272 BFAR_HUMAN reviewed Bifunctional apoptosis regulator (RING finger protein 47) BFAR BAR RNF47 Homo sapiens (Human) 450 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of IRE1-mediated unfolded protein response [GO:1903895]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0005783; GO:0005887; GO:0006915; GO:0008270; GO:0016020; GO:0030176; GO:0030674; GO:0042787; GO:0043066; GO:0043161; GO:0051865; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:1903895 0 0 0 PF00536; Q9P000 CHOYP_LOC100561410.1.1 m.58687 sp COMD9_HUMAN 45.789 190 103 0 23 212 9 198 6.16E-59 186 COMD9_HUMAN reviewed COMM domain-containing protein 9 COMMD9 HSPC166 Homo sapiens (Human) 198 "regulation of transcription, DNA-templated [GO:0006355]; sodium ion transport [GO:0006814]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0006814; GO:0016023 0 0 0 PF07258; A3KPP4 CHOYP_LOC577507.1.1 m.45248 sp S2535_DANRE 53.691 298 137 1 1 298 1 297 6.17E-117 341 S2535_DANRE reviewed Solute carrier family 25 member 35 slc25a35 si:ch211-268m12.5 Danio rerio (Zebrafish) (Brachydanio rerio) 298 translation [GO:0006412]; transport [GO:0006810] GO:0003735; GO:0005743; GO:0006412; GO:0006810; GO:0016021 0 0 0 PF00153; P20929 CHOYP_LOC663855.3.5 m.1804 sp NEBU_HUMAN 36.449 321 171 7 21 312 6353 6669 6.17E-47 172 NEBU_HUMAN reviewed Nebulin NEB Homo sapiens (Human) 6669 muscle filament sliding [GO:0030049]; muscle organ development [GO:0007517]; regulation of actin filament length [GO:0030832]; somatic muscle development [GO:0007525] GO:0005829; GO:0007517; GO:0007525; GO:0008307; GO:0015629; GO:0030018; GO:0030049; GO:0030832; GO:0070062 0 0 0 PF00880;PF14604; P32939 CHOYP_LOC586472.1.1 m.60215 sp YPT7_YEAST 31.333 150 78 3 24 172 9 134 6.17E-16 79.7 YPT7_YEAST reviewed GTP-binding protein YPT7 YPT7 VAM4 YML001W YM8270.02 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 208 "CVT pathway [GO:0032258]; endocytosis [GO:0006897]; macroautophagy [GO:0016236]; phagosome-lysosome fusion [GO:0090385]; piecemeal microautophagy of nucleus [GO:0034727]; protein localization to vacuole [GO:0072665]; regulation of vacuole fusion, non-autophagic [GO:0032889]; retrograde transport, endosome to Golgi [GO:0042147]; small GTPase mediated signal transduction [GO:0007264]; vacuole inheritance [GO:0000011]; vesicle-mediated transport [GO:0016192]" GO:0000011; GO:0000324; GO:0000329; GO:0003924; GO:0005525; GO:0005764; GO:0005770; GO:0005829; GO:0006897; GO:0007264; GO:0016192; GO:0016236; GO:0032258; GO:0032889; GO:0034727; GO:0042147; GO:0045335; GO:0072665; GO:0090385; GO:1990816 0 0 0 PF00071; P34501 CHOYP_Y1004.1.1 m.18927 sp YMS5_CAEEL 26.45 1017 615 32 148 1062 311 1296 6.17E-85 304 YMS5_CAEEL reviewed Uncharacterized protein K03H1.5 K03H1.5 Caenorhabditis elegans 1385 cell-matrix adhesion [GO:0007160] GO:0007160 0 0 0 PF03782;PF06119;PF00084;PF00094; P86881 CHOYP_LOC100909144.1.2 m.46036 sp NGB_DISMA 28.369 141 98 3 43 182 12 150 6.17E-14 70.5 NGB_DISMA reviewed Neuroglobin 0 Dissostichus mawsoni (Antarctic cod) 159 0 GO:0005344; GO:0005737; GO:0019825; GO:0020037; GO:0043204; GO:0046872 0 0 0 PF00042; Q29116 CHOYP_LOC555374.1.2 m.26438 sp TENA_PIG 43.541 209 115 2 6 214 1528 1733 6.17E-54 188 TENA_PIG reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (P230) (Tenascin-C) (TN-C) TNC HXB Sus scrofa (Pig) 1746 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041; Q2L6K8 CHOYP_LOC100184874.1.1 m.41851 sp CNPY4_DANRE 47.959 196 86 4 4 196 8 190 6.17E-60 191 CNPY4_DANRE reviewed Protein canopy 4 cnpy4 Danio rerio (Zebrafish) (Brachydanio rerio) 217 0 GO:0005576 0 0 0 PF11938; Q60722 CHOYP_ITF2.1.1 m.1445 sp ITF2_MOUSE 39.387 424 178 24 45 415 12 409 6.17E-37 147 ITF2_MOUSE reviewed Transcription factor 4 (TCF-4) (Class A helix-loop-helix transcription factor ME2) (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) Tcf4 Itf2 Sef2 Mus musculus (Mouse) 670 "DNA-templated transcription, initiation [GO:0006352]; endothelial cell activation [GO:0042118]; negative regulation of angiogenesis [GO:0016525]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein-DNA complex assembly [GO:0065004]; regulation of transcription, DNA-templated [GO:0006355]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000122; GO:0000790; GO:0000978; GO:0001011; GO:0001077; GO:0001087; GO:0001093; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0005634; GO:0005667; GO:0006352; GO:0006355; GO:0006367; GO:0008022; GO:0010629; GO:0016525; GO:0042118; GO:0042802; GO:0042803; GO:0043425; GO:0043621; GO:0045666; GO:0045893; GO:0045944; GO:0046982; GO:0065004; GO:0070888; GO:1900746 0 0 0 PF00010; Q6NXT1 CHOYP_BRAFLDRAFT_102566.1.1 m.6536 sp ANR54_HUMAN 32.051 156 94 3 11 156 113 266 6.17E-13 73.6 ANR54_HUMAN reviewed Ankyrin repeat domain-containing protein 54 (Lyn-interacting ankyrin repeat protein) ANKRD54 LIAR Homo sapiens (Human) 300 nucleocytoplasmic transport [GO:0006913]; positive regulation of erythrocyte differentiation [GO:0045648]; regulation of intracellular signal transduction [GO:1902531] GO:0005634; GO:0005737; GO:0006913; GO:0019887; GO:0030496; GO:0045648; GO:1902531 0 0 0 0 Q6PB70 CHOYP_ANO8.1.1 m.23817 sp ANO8_MOUSE 48.78 205 105 0 23 227 37 241 6.17E-62 211 ANO8_MOUSE reviewed Anoctamin-8 (Transmembrane protein 16H) Ano8 Kiaa1623 Tmem16h Mus musculus (Mouse) 1060 chloride transport [GO:0006821] GO:0005229; GO:0005622; GO:0005886; GO:0006821; GO:0016021 0 0 0 PF04547; Q6PQZ3 CHOYP_INSI2.1.1 m.59455 sp INSI2_PIG 68.557 194 56 3 1 194 26 214 6.17E-94 276 INSI2_PIG reviewed Insulin-induced gene 2 protein (INSIG-2) INSIG2 Sus scrofa (Pig) 225 cholesterol metabolic process [GO:0008203] GO:0005789; GO:0008203; GO:0016021 0 0 0 PF07281; Q8BGW0 CHOYP_contig_045864 m.53523 sp THMS1_MOUSE 21.272 456 269 19 166 601 166 551 6.17E-08 59.7 THMS1_MOUSE reviewed Protein THEMIS (Grb2-associating protein) (Gasp) (Protein thylex) (Thymocyte-expressed molecule involved in selection) Themis Mus musculus (Mouse) 636 adaptive immune response [GO:0002250]; negative T cell selection [GO:0043383]; positive T cell selection [GO:0043368]; T cell receptor signaling pathway [GO:0050852] GO:0002250; GO:0005634; GO:0005737; GO:0005911; GO:0008180; GO:0043368; GO:0043383; GO:0050852 0 0 0 PF12736; Q8TCA0 CHOYP_LOC100642680.1.1 m.6611 sp LRC20_HUMAN 32.278 158 103 2 7 160 4 161 6.17E-26 100 LRC20_HUMAN reviewed Leucine-rich repeat-containing protein 20 LRRC20 UNQ2429/PRO4989 Homo sapiens (Human) 184 0 0 0 0 0 PF00560;PF13855; Q9ESN6 CHOYP_TRIM3.24.58 m.32676 sp TRIM2_MOUSE 25 248 163 11 37 271 484 721 6.17E-10 62.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9P2K3 CHOYP_LOC100744356.1.1 m.49326 sp RCOR3_HUMAN 48.126 507 189 10 40 505 1 474 6.17E-151 443 RCOR3_HUMAN reviewed REST corepressor 3 RCOR3 KIAA1343 Homo sapiens (Human) 495 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003700; GO:0003714; GO:0005634; GO:0005667; GO:0006351; GO:0008134; GO:0017053; GO:0044212 0 0 0 PF01448;PF00249; Q9ULJ8 CHOYP_LOC100720996.1.1 m.24778 sp NEB1_HUMAN 50 96 48 0 113 208 978 1073 6.17E-25 105 NEB1_HUMAN reviewed Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A) PPP1R9A KIAA1222 Homo sapiens (Human) 1098 actin filament organization [GO:0007015]; aging [GO:0007568]; calcium-mediated signaling [GO:0019722]; cellular response to toxic substance [GO:0097237]; excitatory postsynaptic potential [GO:0060079]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of stress fiber assembly [GO:0051497]; neuron projection development [GO:0031175]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of long term synaptic depression [GO:1900454]; positive regulation of protein kinase activity [GO:0045860]; regulation of actin filament polymerization [GO:0030833]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; regulation of synapse structural plasticity [GO:0051823] GO:0005737; GO:0005829; GO:0007015; GO:0007568; GO:0014069; GO:0015629; GO:0019722; GO:0030054; GO:0030175; GO:0030425; GO:0030833; GO:0030864; GO:0031175; GO:0031594; GO:0043025; GO:0044326; GO:0045860; GO:0051015; GO:0051489; GO:0051497; GO:0051823; GO:0051963; GO:0060079; GO:0060999; GO:0061001; GO:0097237; GO:1900272; GO:1900454; GO:1904049; GO:1990761 0 0 0 PF00595;PF07647; Q9VYN8 CHOYP_BRAFLDRAFT_144973.1.1 m.43469 sp TENA_DROME 26.316 190 113 7 47 230 650 818 6.17E-08 56.2 TENA_DROME reviewed Teneurin-a (Tena) (Tenascin-like protein) Ten-a CG42338 Drosophila melanogaster (Fruit fly) 3004 cell adhesion [GO:0007155]; central complex development [GO:0048036]; maintenance of presynaptic active zone structure [GO:0048790]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of locomotion [GO:0040017]; postsynaptic membrane organization [GO:0001941]; presynaptic membrane organization [GO:0097090]; regulation of homotypic cell-cell adhesion [GO:0034110]; regulation of terminal button organization [GO:2000331]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; synaptic target attraction [GO:0016200]; synaptic target recognition [GO:0008039]; synaptic vesicle membrane organization [GO:0048499] GO:0001941; GO:0003824; GO:0005576; GO:0005578; GO:0007155; GO:0007274; GO:0008039; GO:0016021; GO:0016200; GO:0030054; GO:0030424; GO:0031594; GO:0034110; GO:0034116; GO:0040017; GO:0042734; GO:0042803; GO:0043025; GO:0046982; GO:0048036; GO:0048499; GO:0048786; GO:0048788; GO:0048790; GO:0050808; GO:0051124; GO:0097090; GO:2000331 0 0 0 PF07974;PF15636; A4IF63 CHOYP_LOC101163206.1.1 m.55052 sp TRIM2_BOVIN 27.004 237 152 7 8 236 484 707 6.18E-09 59.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O60494 CHOYP_CPIPJ_CPIJ000326.1.1 m.9644 sp CUBN_HUMAN 25.199 377 217 17 59 424 1288 1610 6.18E-12 72.8 CUBN_HUMAN reviewed Cubilin (460 kDa receptor) (Intestinal intrinsic factor receptor) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) CUBN IFCR Homo sapiens (Human) 3623 cholesterol metabolic process [GO:0008203]; cobalamin metabolic process [GO:0009235]; cobalamin transport [GO:0015889]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; tissue homeostasis [GO:0001894]; vitamin D metabolic process [GO:0042359] GO:0001894; GO:0004872; GO:0005215; GO:0005509; GO:0005765; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0005905; GO:0006898; GO:0008203; GO:0009235; GO:0010008; GO:0015031; GO:0015889; GO:0016020; GO:0016324; GO:0030139; GO:0031232; GO:0031419; GO:0031526; GO:0042157; GO:0042359; GO:0042803; GO:0042953; GO:0043202; GO:0070062 0 0 0 PF00431;PF00008;PF12947;PF07645; O70566 CHOYP_DIAPH1.1.1 m.55416 sp DIAP2_MOUSE 45.551 472 238 5 620 1086 618 1075 6.18E-120 399 DIAP2_MOUSE reviewed Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3) Diaph2 Diap2 Mus musculus (Mouse) 1098 actin filament polymerization [GO:0030041]; multicellular organism development [GO:0007275]; oogenesis [GO:0048477] GO:0003779; GO:0007275; GO:0030041; GO:0048477 0 0 0 PF06345;PF06367;PF06371;PF02181; P16157 CHOYP_TVAG_020440.17.21 m.54135 sp ANK1_HUMAN 36.519 293 186 0 10 302 206 498 6.18E-53 189 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P25107 CHOYP_LOC693244.1.1 m.55536 sp PTH1R_DIDVI 39.636 439 236 12 33 452 66 494 6.18E-90 290 PTH1R_DIDVI reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) 585 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166] GO:0004991; GO:0005887; GO:0007166; GO:0007188; GO:0017046; GO:0043621 0 0 0 PF00002;PF02793; P54921 CHOYP_BRAFLDRAFT_114106.1.1 m.28307 sp SNAA_RAT 70.144 278 80 2 17 292 19 295 6.18E-146 414 SNAA_RAT reviewed Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) Napa Snap Snapa Rattus norvegicus (Rat) 295 "apical protein localization [GO:0045176]; brain development [GO:0007420]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; neuron differentiation [GO:0030182]; regulation of synaptic vesicle priming [GO:0010807]; SNARE complex disassembly [GO:0035494]; synaptic transmission, glutamatergic [GO:0035249]" GO:0000149; GO:0005483; GO:0005774; GO:0006886; GO:0007420; GO:0010807; GO:0019905; GO:0030182; GO:0035249; GO:0035494; GO:0043195; GO:0043209; GO:0045176; GO:0061025; GO:0070044; GO:0070062 0 0 cd15832; 0 P55210 CHOYP_CASP7.14.23 m.37310 sp CASP7_HUMAN 30.864 243 120 10 63 285 87 301 6.18E-18 85.5 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 Q1L8X9 CHOYP_VGLU1.1.1 m.23414 sp VGLU3_DANRE 39.259 270 161 3 5 271 244 513 6.18E-63 212 VGLU3_DANRE reviewed Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) slc17a8 vglut3 si:ch211-264e16.4 Danio rerio (Zebrafish) (Brachydanio rerio) 590 equilibrioception [GO:0050957]; neurotransmitter transport [GO:0006836]; regulation of synapse structure or activity [GO:0050803]; sodium ion transport [GO:0006814]; vestibular reflex [GO:0060005] GO:0005313; GO:0006814; GO:0006836; GO:0015293; GO:0016021; GO:0030054; GO:0030672; GO:0043005; GO:0050803; GO:0050957; GO:0060005 0 0 cd06174; PF07690; Q5XHB2 CHOYP_DWIL_GK17106.1.1 m.42167 sp DUS22_XENTR 54.706 170 77 0 1 170 1 170 6.18E-66 208 DUS22_XENTR reviewed Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) dusp22 TEgg009e03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 209 positive regulation of JNK cascade [GO:0046330]; regulation of cell proliferation [GO:0042127]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0004725; GO:0005634; GO:0005737; GO:0007179; GO:0008138; GO:0042127; GO:0046330 0 0 0 PF00782; Q68EK7 CHOYP_RAB4B.1.1 m.55402 sp RAB4B_DANRE 86.854 213 26 1 1 211 1 213 6.18E-137 385 RAB4B_DANRE reviewed Ras-related protein Rab-4B rab4b zgc:101015 Danio rerio (Zebrafish) (Brachydanio rerio) 213 protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005768; GO:0005886; GO:0007264; GO:0015031; GO:0030100; GO:0032593 0 0 0 PF00071; Q6DD44 CHOYP_CPIPJ_CPIJ009812.1.1 m.47469 sp XPR1_XENLA 60.215 93 31 1 7 99 586 672 6.18E-31 117 XPR1_XENLA reviewed Xenotropic and polytropic retrovirus receptor 1 homolog xpr1 Xenopus laevis (African clawed frog) 692 cellular phosphate ion homeostasis [GO:0030643]; phosphate ion transmembrane transport [GO:0035435] GO:0000822; GO:0015114; GO:0015562; GO:0016021; GO:0030643; GO:0031226; GO:0035435 0 0 0 PF03124;PF03105; Q8CIC2 CHOYP_NUPL2.1.2 m.4693 sp NUPL2_MOUSE 29.63 405 206 12 12 411 88 418 6.18E-23 103 NUPL2_MOUSE reviewed Nucleoporin-like protein 2 (NLP-1) Nupl2 Mus musculus (Mouse) 420 mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611] GO:0001750; GO:0005049; GO:0005634; GO:0005643; GO:0005654; GO:0005737; GO:0006611; GO:0031965; GO:0044822; GO:0046872; GO:0051028 0 0 0 0 Q90705 CHOYP_LOC101242512.1.1 m.48608 sp EF2_CHICK 79.439 107 22 0 3 109 611 717 6.18E-54 183 EF2_CHICK reviewed Elongation factor 2 (EF-2) EEF2 Gallus gallus (Chicken) 858 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; Q92038 CHOYP_LOC100564278.1.1 m.1665 sp ACOD_CYPCA 74.854 171 43 0 493 663 69 239 6.18E-87 278 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; Q9CZJ2 CHOYP_HSPA12A.1.27 m.13508 sp HS12B_MOUSE 28.216 241 162 5 6 236 444 683 6.18E-27 112 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9DCM4 CHOYP_COPD.1.1 m.37390 sp DNAL4_MOUSE 72.381 105 29 0 1 105 1 105 6.18E-57 174 DNAL4_MOUSE reviewed "Dynein light chain 4, axonemal" Dnal4 Dnalc4 Mus musculus (Mouse) 105 microtubule-based process [GO:0007017] GO:0003774; GO:0005737; GO:0005874; GO:0005929; GO:0007017; GO:0030286 0 0 0 PF01221; Q9DCM4 CHOYP_LOC100375307.1.2 m.50297 sp DNAL4_MOUSE 72.381 105 29 0 1 105 1 105 6.18E-57 174 DNAL4_MOUSE reviewed "Dynein light chain 4, axonemal" Dnal4 Dnalc4 Mus musculus (Mouse) 105 microtubule-based process [GO:0007017] GO:0003774; GO:0005737; GO:0005874; GO:0005929; GO:0007017; GO:0030286 0 0 0 PF01221; Q9DCM4 CHOYP_LOC100375307.2.2 m.63049 sp DNAL4_MOUSE 72.381 105 29 0 1 105 1 105 6.18E-57 174 DNAL4_MOUSE reviewed "Dynein light chain 4, axonemal" Dnal4 Dnalc4 Mus musculus (Mouse) 105 microtubule-based process [GO:0007017] GO:0003774; GO:0005737; GO:0005874; GO:0005929; GO:0007017; GO:0030286 0 0 0 PF01221; Q9U3W6 CHOYP_LOC100377009.2.10 m.2998 sp MAB21_DROME 24.706 170 110 5 29 189 183 343 6.18E-07 53.9 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; Q9ULL1 CHOYP_LOC100367084.6.22 m.31842 sp PKHG1_HUMAN 51.553 322 155 1 354 675 114 434 6.18E-102 363 PKHG1_HUMAN reviewed Pleckstrin homology domain-containing family G member 1 PLEKHG1 KIAA1209 Homo sapiens (Human) 1385 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF00621; A8K0R7 CHOYP_LOC100900174.1.1 m.14983 sp ZN839_HUMAN 38.532 109 62 1 499 602 336 444 6.19E-15 83.2 ZN839_HUMAN reviewed Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50) ZNF839 C14orf131 Homo sapiens (Human) 811 0 GO:0046872 0 0 0 PF15961; O01971 CHOYP_LOC101162206.1.1 m.53261 sp EMR1_CAEEL 28.387 155 93 5 3 148 2 147 6.19E-08 52.8 EMR1_CAEEL reviewed Emerin homolog 1 (Ce-emerin) emr-1 M01D7.6 Caenorhabditis elegans 166 chromosome segregation [GO:0007059]; mitotic cytokinesis [GO:0000281]; response to X-ray [GO:0010165] GO:0000281; GO:0005521; GO:0005635; GO:0005639; GO:0007059; GO:0010165 0 0 0 PF03020; O01971 CHOYP_LOC586472.1.1 m.60216 sp EMR1_CAEEL 28.387 155 93 5 3 148 2 147 6.19E-08 52.8 EMR1_CAEEL reviewed Emerin homolog 1 (Ce-emerin) emr-1 M01D7.6 Caenorhabditis elegans 166 chromosome segregation [GO:0007059]; mitotic cytokinesis [GO:0000281]; response to X-ray [GO:0010165] GO:0000281; GO:0005521; GO:0005635; GO:0005639; GO:0007059; GO:0010165 0 0 0 PF03020; O93567 CHOYP_LOC100892078.1.1 m.26453 sp ZBT7A_CHICK 27.451 153 99 4 12 160 16 160 6.19E-07 56.2 ZBT7A_CHICK reviewed Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma-related factor) (cLRF) ZBTB7A LRF ZBTB7 Gallus gallus (Chicken) 546 "transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0001078; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00651;PF00096; P49013 CHOYP_NOTCH.6.6 m.62784 sp FBP3_STRPU 38.506 348 177 15 703 1043 180 497 6.19E-49 187 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P84175 CHOYP_LOC100376688.5.8 m.37895 sp RS12_CHICK 81.89 127 23 0 26 152 6 132 6.19E-73 217 RS12_CHICK reviewed 40S ribosomal protein S12 RPS12 Gallus gallus (Chicken) 132 translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0044822 0 0 0 PF01248; Q24799 CHOYP_LOC100212224.1.1 m.37724 sp MYPH_ECHGR 45.729 199 97 3 10 206 1 190 6.19E-54 173 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q5BIM1 CHOYP_LOC100373444.2.79 m.1185 sp TRI45_BOVIN 27.189 217 136 6 8 212 132 338 6.19E-15 81.3 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q96MT8 CHOYP_CEP63.1.2 m.24656 sp CEP63_HUMAN 28.631 723 396 21 58 691 10 701 6.19E-53 197 CEP63_HUMAN reviewed Centrosomal protein of 63 kDa (Cep63) CEP63 Homo sapiens (Human) 703 cell division [GO:0051301]; centriole replication [GO:0007099]; de novo centriole assembly [GO:0098535]; DNA damage checkpoint [GO:0000077]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225] GO:0000077; GO:0000086; GO:0000922; GO:0005813; GO:0005814; GO:0005829; GO:0007067; GO:0007099; GO:0042770; GO:0051225; GO:0051301; GO:0098535 0 0 0 PF17045; Q99999 CHOYP_BRAFLDRAFT_129875.1.2 m.6998 sp G3ST1_HUMAN 33.692 279 156 10 57 328 67 323 6.19E-35 137 G3ST1_HUMAN reviewed Galactosylceramide sulfotransferase (GalCer sulfotransferase) (EC 2.8.2.11) (3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase) (3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase) (Cerebroside sulfotransferase) GAL3ST1 CST Homo sapiens (Human) 423 galactosylceramide biosynthetic process [GO:0006682]; myelination [GO:0042552]; protein N-linked glycosylation [GO:0006487]; spermatogenesis [GO:0007283] GO:0000139; GO:0001733; GO:0005887; GO:0006487; GO:0006682; GO:0007283; GO:0008146; GO:0016020; GO:0042552 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF06990; Q9H8W5 CHOYP_LOC100373444.50.79 m.42407 sp TRI45_HUMAN 24.895 237 165 9 4 233 127 357 6.19E-09 59.3 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; B1WBP0 CHOYP_MPPD2.2.3 m.28703 sp MPPD2_RAT 48.443 289 138 5 3 284 9 293 6.20E-88 267 MPPD2_RAT reviewed Metallophosphoesterase MPPED2 (EC 3.1.-.-) (239FB) (Fetal brain protein 239 homolog) (Metallophosphoesterase domain-containing protein 2) Mpped2 Rattus norvegicus (Rat) 294 0 GO:0016787; GO:0046872 0 0 0 PF00149; D3YXG0 CHOYP_BRAFLDRAFT_88566.11.11 m.31257 sp HMCN1_MOUSE 46.313 339 182 0 1 339 4529 4867 6.20E-102 333 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O43542 CHOYP_LOC100368320.1.1 m.19409 sp XRCC3_HUMAN 41.026 351 170 7 7 338 6 338 6.20E-80 250 XRCC3_HUMAN reviewed DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3) XRCC3 Homo sapiens (Human) 346 cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; meiotic DNA recombinase assembly [GO:0000707]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; reciprocal meiotic recombination [GO:0007131]; regulation of centrosome duplication [GO:0010824]; resolution of mitotic recombination intermediates [GO:0071140]; response to ionizing radiation [GO:0010212]; response to organic substance [GO:0010033]; strand displacement [GO:0000732]; strand invasion [GO:0042148]; t-circle formation [GO:0090656]; telomere maintenance via recombination [GO:0000722] GO:0000150; GO:0000707; GO:0000722; GO:0000724; GO:0000731; GO:0000732; GO:0000784; GO:0003690; GO:0003697; GO:0005524; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005739; GO:0006281; GO:0006310; GO:0006974; GO:0007131; GO:0008094; GO:0010033; GO:0010212; GO:0010824; GO:0033063; GO:0033065; GO:0036297; GO:0042148; GO:0048471; GO:0071140; GO:0090267; GO:0090656 0 0 0 PF08423; P15941 CHOYP_LOC100929680.1.2 m.17333 sp MUC1_HUMAN 37.158 915 459 32 2995 3843 78 942 6.20E-48 194 MUC1_HUMAN reviewed Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] MUC1 PUM Homo sapiens (Human) 1255 "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by competitive promoter binding [GO:0010944]; O-glycan processing [GO:0016266]; positive regulation of histone H4 acetylation [GO:0090240]; positive regulation of transcription from RNA polymerase II promoter in response to stress [GO:0036003]; regulation of transcription from RNA polymerase II promoter in response to stress [GO:0043618]" GO:0000790; GO:0000978; GO:0002039; GO:0003712; GO:0005615; GO:0005796; GO:0005887; GO:0006977; GO:0006978; GO:0010944; GO:0016266; GO:0016324; GO:0031982; GO:0033629; GO:0036003; GO:0043618; GO:0070062; GO:0090240; GO:1902166 0 0 0 PF01390; P52900 CHOYP_PDHA-1.1.1 m.67024 sp ODPA_SMIMA 68.056 144 46 0 52 195 6 149 6.20E-68 214 ODPA_SMIMA reviewed "Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (PDHE1-A) (EC 1.2.4.1) (Fragment)" PDHA Sminthopsis macroura (Stripe-faced dunnart) 363 acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; tricarboxylic acid cycle [GO:0006099] GO:0004738; GO:0004739; GO:0005759; GO:0006006; GO:0006086; GO:0006099; GO:0045254 0 0 0 PF00676; Q1HG43 CHOYP_DOXA2.1.1 m.35713 sp DOXA1_HUMAN 34.34 265 166 6 13 272 8 269 6.20E-33 130 DOXA1_HUMAN reviewed Dual oxidase maturation factor 1 (Dual oxidase activator 1) (Numb-interacting protein) DUOXA1 NIP NUMBIP Homo sapiens (Human) 343 hydrogen peroxide metabolic process [GO:0042743]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein transport [GO:0015031]; regulation of inflammatory response [GO:0050727]; regulation of thyroid hormone generation [GO:2000609] GO:0005789; GO:0005886; GO:0015031; GO:0016020; GO:0016021; GO:0042743; GO:0045666; GO:0050727; GO:2000379; GO:2000609 0 0 0 PF10204; Q2EY13 CHOYP_BRAFLDRAFT_78749.4.5 m.42437 sp PRTGB_DANRE 23.794 311 201 14 297 588 131 424 6.20E-06 53.9 PRTGB_DANRE reviewed Protogenin B (Fragment) prtgb Danio rerio (Zebrafish) (Brachydanio rerio) 1069 multicellular organism development [GO:0007275] GO:0007275; GO:0016021 0 0 0 PF00041;PF07679; Q49LS8 CHOYP_XKR7.2.2 m.33939 sp XKR6_TETNG 26.146 371 234 6 230 577 82 435 6.20E-30 127 XKR6_TETNG reviewed XK-related protein 6 xkr6 xrg6 GSTENG00030285001 GSTENG00030286001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 578 0 GO:0016021 0 0 0 PF09815; Q5XGF7 CHOYP_DHRS3.1.1 m.43247 sp RDH10_XENTR 38.801 317 158 7 36 318 10 324 6.20E-68 219 RDH10_XENTR reviewed Retinol dehydrogenase 10 (EC 1.1.1.300) rdh10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 341 retinoic acid biosynthetic process [GO:0002138] GO:0002138; GO:0005789; GO:0016021; GO:0031090; GO:0052650 PATHWAY: Cofactor metabolism; retinol metabolism. 0 0 PF00106; Q5ZI20 CHOYP_BRAFLDRAFT_126133.1.1 m.5566 sp S39AD_CHICK 54.142 338 115 8 66 396 60 364 6.20E-108 325 S39AD_CHICK reviewed Zinc transporter ZIP13 (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) (ZIP-13) SLC39A13 ZIP13 RCJMB04_31f18 Gallus gallus (Chicken) 366 cellular zinc ion homeostasis [GO:0006882]; connective tissue development [GO:0061448]; zinc II ion transmembrane transport [GO:0071577] GO:0000139; GO:0005385; GO:0006882; GO:0016021; GO:0048471; GO:0061448; GO:0071577 0 0 0 PF02535; Q68CP9 CHOYP_ARID2.1.2 m.32278 sp ARID2_HUMAN 36.753 653 372 9 1 629 1 636 6.20E-129 450 ARID2_HUMAN reviewed AT-rich interactive domain-containing protein 2 (ARID domain-containing protein 2) (BRG1-associated factor 200) (BAF200) (Zinc finger protein with activation potential) (Zipzap/p200) ARID2 KIAA1557 Homo sapiens (Human) 1835 "covalent chromatin modification [GO:0016569]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005654; GO:0005886; GO:0006337; GO:0006351; GO:0006355; GO:0008285; GO:0016569; GO:0030336; GO:0046872; GO:0090544 0 0 0 PF01388;PF02257; Q6AX23 CHOYP_BRAFLDRAFT_88784.1.1 m.51882 sp QSOX2_XENLA 33.333 615 378 13 24 620 32 632 6.20E-104 333 QSOX2_XENLA reviewed Sulfhydryl oxidase 2 (EC 1.8.3.2) (Quiescin Q6-like protein 1) qsox2 qscn6l1 Xenopus laevis (African clawed frog) 661 cell redox homeostasis [GO:0045454] GO:0005623; GO:0016021; GO:0016972; GO:0045454 0 0 0 PF04777;PF00085; Q6ZN84 CHOYP_LOC100373351.1.3 m.49572 sp CCD81_HUMAN 51.832 191 92 0 24 214 23 213 6.20E-65 233 CCD81_HUMAN reviewed Coiled-coil domain-containing protein 81 CCDC81 Homo sapiens (Human) 652 0 GO:0005737; GO:0005813 0 0 0 PF14908; Q86VX2 CHOYP_BRAFLDRAFT_108193.1.2 m.1093 sp COMD7_HUMAN 54.464 112 51 0 1 112 51 162 6.20E-36 125 COMD7_HUMAN reviewed COMM domain-containing protein 7 COMMD7 C20orf92 Homo sapiens (Human) 200 "negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" GO:0006351; GO:0016023; GO:0032088; GO:0033209; GO:0043231; GO:0045892; GO:0051059; GO:0070062 0 0 0 PF07258; Q8BZP8 CHOYP_CCAPR.2.2 m.43173 sp NPSR1_MOUSE 26.623 154 111 2 3 155 36 188 6.20E-08 58.2 NPSR1_MOUSE reviewed Neuropeptide S receptor (G-protein coupled receptor 154) (G-protein coupled receptor PGR14) Npsr1 Gpr154 Pgr14 Mus musculus (Mouse) 371 neuropeptide signaling pathway [GO:0007218]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281] GO:0005000; GO:0005737; GO:0005887; GO:0007218; GO:0008188; GO:0051281 0 0 0 PF00001; Q8WZ42 CHOYP_TTN.9.9 m.51076 sp TITIN_HUMAN 28.076 317 199 13 179 479 8867 9170 6.20E-20 98.2 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q96C34 CHOYP_ISCW_ISCW015959.1.1 m.59300 sp RUND1_HUMAN 51.337 187 89 1 1 185 427 613 6.20E-53 181 RUND1_HUMAN reviewed RUN domain-containing protein 1 RUNDC1 LP5161 Homo sapiens (Human) 613 activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0006886; GO:0012505; GO:0017137; GO:0031338; GO:0090630 0 0 0 PF02759; Q96GP6 CHOYP_MEGF6.12.59 m.24291 sp SREC2_HUMAN 39.487 195 103 7 34 224 236 419 6.20E-28 115 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9D824 CHOYP_LOC100217869.2.2 m.41350 sp FIP1_MOUSE 51.887 106 46 2 91 196 95 195 6.20E-24 108 FIP1_MOUSE reviewed Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1 protein) Fip1l1 Mus musculus (Mouse) 581 mRNA polyadenylation [GO:0006378] GO:0005634; GO:0005847; GO:0006378; GO:0044822 0 0 0 PF05182; Q9J569 CHOYP_TVAG_287350.4.5 m.31577 sp V162_FOWPN 27.436 390 211 10 67 451 25 347 6.20E-20 98.6 V162_FOWPN reviewed Putative ankyrin repeat protein FPV162 FPV162 Fowlpox virus (strain NVSL) (FPV) 603 0 0 0 0 0 PF12796;PF09372; Q9QYM9 CHOYP_KAZAL2.1.1 m.36918 sp TEFF2_MOUSE 46.939 49 26 0 62 110 91 139 6.20E-08 52.4 TEFF2_MOUSE reviewed Tomoregulin-2 (TR-2) (Transmembrane protein with EGF-like and two follistatin-like domains) Tmeff2 MNCb-1026 Mus musculus (Mouse) 374 "negative regulation of cell migration [GO:0030336]; negative regulation of integrin biosynthetic process [GO:0045720]; negative regulation of stress fiber assembly [GO:0051497]; wound healing, spreading of cells [GO:0044319]" GO:0016021; GO:0030336; GO:0044319; GO:0045720; GO:0051497 0 0 0 PF07648; Q9UBS9 CHOYP_SUCO.1.1 m.49564 sp SUCO_HUMAN 37.647 170 99 3 338 502 304 471 6.20E-31 133 SUCO_HUMAN reviewed SUN domain-containing ossification factor (Membrane protein CH1) (Protein osteopotentia homolog) (SUN-like protein 1) SUCO C1orf9 CH1 OPT SLP1 Homo sapiens (Human) 1254 multicellular organism development [GO:0007275]; ossification [GO:0001503]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of bone remodeling [GO:0046850] GO:0001503; GO:0005791; GO:0007275; GO:0016020; GO:0016021; GO:0030867; GO:0032967; GO:0045669; GO:0046850 0 0 0 PF07738; A1ZA47 CHOYP_SMP_006860.2.4.4 m.66077 sp ZASP_DROME 39.13 69 42 0 37 105 20 88 6.21E-09 57.4 ZASP_DROME reviewed PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) 2194 muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952] GO:0001725; GO:0001952; GO:0003779; GO:0005915; GO:0005925; GO:0005927; GO:0008270; GO:0015629; GO:0016323; GO:0030018; GO:0030239; GO:0031252; GO:0045177; GO:0045178; GO:0051371; GO:0061061 0 0 0 PF15936;PF00412;PF00595; P11940 CHOYP_PABPA.1.1 m.48961 sp PABP1_HUMAN 75.185 270 66 1 6 275 1 269 6.21E-149 434 PABP1_HUMAN reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 Homo sapiens (Human) 636 "gene silencing by RNA [GO:0031047]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulation of mRNA stability [GO:0043488]; translational initiation [GO:0006413]" GO:0000166; GO:0000184; GO:0000289; GO:0000398; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006378; GO:0006413; GO:0008022; GO:0008143; GO:0008266; GO:0008494; GO:0010494; GO:0016020; GO:0030529; GO:0031047; GO:0036464; GO:0043488; GO:0044822; GO:0045070; GO:0048255; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:2000623 0 0 0 PF00658;PF00076; P16157 CHOYP_TVAG_291510.6.9 m.30900 sp ANK1_HUMAN 23.803 773 452 24 233 910 14 744 6.21E-34 145 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P31944 CHOYP_LOC100931580.2.2 m.44310 sp CASPE_HUMAN 31.915 235 143 5 197 426 19 241 6.21E-29 116 CASPE_HUMAN reviewed "Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]" CASP14 Homo sapiens (Human) 242 cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424] GO:0004197; GO:0005634; GO:0005737; GO:0008544; GO:0031012; GO:0031424; GO:0045095; GO:0070062; GO:0070268; GO:0097153 0 0 0 0 P32429 CHOYP_LOC100366813.5.6 m.38573 sp RL7A_CHICK 75.275 182 43 1 2 183 72 251 6.21E-96 284 RL7A_CHICK reviewed 60S ribosomal protein L7a RPL7A SURF-3 Gallus gallus (Chicken) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0022625; GO:0042788; GO:0044822; GO:0070062 0 0 0 PF01248; P50093 CHOYP_LOC100367895.1.1 m.23456 sp PHB2_CAEEL 24.701 251 141 10 34 263 44 267 6.21E-06 50.4 PHB2_CAEEL reviewed Mitochondrial prohibitin complex protein 2 (Prohibitin-2) phb-2 T24H7.1 Caenorhabditis elegans 294 defecation [GO:0030421]; embryo development ending in birth or egg hatching [GO:0009792]; gonad development [GO:0008406]; mitochondrion morphogenesis [GO:0070584]; oogenesis [GO:0048477]; positive regulation of multicellular organism growth [GO:0040018]; regulation of oxidative phosphorylation [GO:0002082]; regulation of pharyngeal pumping [GO:0043051]; response to oxidative stress [GO:0006979]; spermatogenesis [GO:0007283] GO:0002082; GO:0005739; GO:0006979; GO:0007283; GO:0008406; GO:0009792; GO:0016021; GO:0030421; GO:0031966; GO:0035632; GO:0040018; GO:0043051; GO:0048477; GO:0070584 0 0 cd03401; PF01145; P62909 CHOYP_RS3.4.7 m.42802 sp RS3_RAT 89.041 219 23 1 29 247 18 235 6.21E-140 395 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; Q54KA7 CHOYP_AFUA_1G01020.48.50 m.65369 sp SECG_DICDI 37.186 398 248 2 1 396 72 469 6.21E-69 237 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5REG4 CHOYP_LOC100368715.1.3 m.31823 sp DTX3_PONAB 52.632 190 89 1 736 924 157 346 6.21E-59 208 DTX3_PONAB reviewed Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 347 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] GO:0005737; GO:0007219; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q64077 CHOYP_TAA7E.1.1 m.57000 sp NK2R_CAVPO 25.407 307 190 10 55 348 43 323 6.21E-12 69.7 NK2R_CAVPO reviewed Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 Cavia porcellus (Guinea pig) 402 0 GO:0004995; GO:0005886; GO:0016021 0 0 0 PF00001; Q6PDY2 CHOYP_BRAFLDRAFT_101346.1.1 m.1028 sp AEDO_MOUSE 34.8 250 151 4 15 254 5 252 6.21E-39 139 AEDO_MOUSE reviewed 2-aminoethanethiol dioxygenase (EC 1.13.11.19) (Cysteamine dioxygenase) Ado Gm237 Mus musculus (Mouse) 256 oxidation-reduction process [GO:0055114] GO:0005739; GO:0046872; GO:0047800; GO:0055114 0 0 0 PF07847; Q95KD9 CHOYP_LOC100372720.1.1 m.9896 sp DIRA2_MACFA 79.899 199 39 1 35 232 1 199 6.21E-118 337 DIRA2_MACFA reviewed GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2) DIRAS2 QflA-13004 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 199 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0007264 0 0 0 PF00071; B5XGE7 CHOYP_LOC594590.1.2 m.10772 sp TPC2L_SALSA 74.815 135 34 0 1 135 1 135 6.22E-75 222 TPC2L_SALSA reviewed Trafficking protein particle complex subunit 2-like protein trappc2l tpc2l Salmo salar (Atlantic salmon) 139 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0005783; GO:0005794; GO:0006888; GO:0048471 0 0 0 PF04628; O75179 CHOYP_LOC581927.6.27 m.20052 sp ANR17_HUMAN 35.333 450 231 17 23 419 271 713 6.22E-50 187 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P10394 CHOYP_contig_030266 m.34428 sp POL4_DROME 23.554 242 164 4 3 237 1007 1234 6.22E-20 93.6 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P15153 CHOYP_AAEL_AAEL015271.1.1 m.56223 sp RAC2_HUMAN 72.487 189 52 0 7 195 4 192 6.22E-104 300 RAC2_HUMAN reviewed Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) RAC2 Homo sapiens (Human) 192 actin filament organization [GO:0007015]; bone resorption [GO:0045453]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; G-protein coupled receptor signaling pathway [GO:0007186]; lymphocyte aggregation [GO:0071593]; platelet activation [GO:0030168]; positive regulation of cell proliferation [GO:0008284]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of cell-substrate adhesion [GO:0010810]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mast cell chemotaxis [GO:0060753]; regulation of mast cell degranulation [GO:0043304]; regulation of neutrophil migration [GO:1902622]; regulation of respiratory burst [GO:0060263]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of T cell proliferation [GO:0042129]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005635; GO:0005829; GO:0005886; GO:0005925; GO:0006935; GO:0007015; GO:0007165; GO:0007186; GO:0007264; GO:0008284; GO:0010310; GO:0010592; GO:0010810; GO:0019887; GO:0030027; GO:0030031; GO:0030168; GO:0030670; GO:0042129; GO:0043304; GO:0045453; GO:0051056; GO:0060263; GO:0060753; GO:0070062; GO:0071593; GO:0090023; GO:1902622; GO:1903955 0 0 0 PF00071; P16157 CHOYP_ANK1.6.8 m.52985 sp ANK1_HUMAN 28.361 543 283 12 470 933 139 654 6.22E-49 193 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P56395 CHOYP_CYB5.2.2 m.22896 sp CYB5_MOUSE 57.6 125 50 2 5 128 10 132 6.22E-43 141 CYB5_MOUSE reviewed Cytochrome b5 Cyb5a Cyb5 Mus musculus (Mouse) 134 fatty acid metabolic process [GO:0006631]; response to cadmium ion [GO:0046686] GO:0004768; GO:0005737; GO:0005739; GO:0005789; GO:0006631; GO:0016020; GO:0016021; GO:0019899; GO:0020037; GO:0031090; GO:0043231; GO:0046686; GO:0046872; GO:0070062 0 0 0 PF00173; P62282 CHOYP_RAB35.1.1 m.8278 sp RS11_RAT 74.214 159 38 3 1 157 1 158 6.22E-83 244 RS11_RAT reviewed 40S ribosomal protein S11 Rps11 Rattus norvegicus (Rat) 158 osteoblast differentiation [GO:0001649]; translation [GO:0006412] GO:0001649; GO:0003735; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022627; GO:0044822; GO:0070062 0 0 0 PF00366;PF16205; P83425 CHOYP_HIP.1.3 m.49737 sp HIP_MYTED 30.216 139 90 2 91 222 60 198 6.22E-12 66.2 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q14162 CHOYP_BRAFLDRAFT_224574.12.18 m.46120 sp SREC_HUMAN 34.722 144 73 6 191 317 242 381 6.22E-13 73.2 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q5DU00 CHOYP_DCDC2.2.7 m.35510 sp DCDC2_MOUSE 29.117 419 225 16 20 414 19 389 6.22E-35 138 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q5E951 CHOYP_BRAFLDRAFT_275787.1.2 m.15360 sp TBCB_BOVIN 55.328 244 103 3 7 249 6 244 6.22E-93 276 TBCB_BOVIN reviewed Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) TBCB CKAP1 Bos taurus (Bovine) 244 cell differentiation [GO:0030154]; nervous system development [GO:0007399]; post-chaperonin tubulin folding pathway [GO:0007023] GO:0005654; GO:0005829; GO:0005874; GO:0007023; GO:0007399; GO:0030154 0 0 0 PF01302;PF14560; Q5M7S0 CHOYP_LOC574943.1.1 m.56445 sp S38A9_XENTR 41.093 567 287 10 9 544 4 554 6.22E-138 414 S38A9_XENTR reviewed Sodium-coupled neutral amino acid transporter 9 (Solute carrier family 38 member 9) slc38a9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 554 amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of TOR signaling [GO:0032008] GO:0003333; GO:0005764; GO:0005765; GO:0005770; GO:0005783; GO:0006865; GO:0015171; GO:0016021; GO:0031902; GO:0032008; GO:0071230 0 0 0 PF01490; Q8BTI8 CHOYP_LOC100372992.2.2 m.34206 sp SRRM2_MOUSE 57.143 189 75 5 1 187 1 185 6.22E-57 209 SRRM2_MOUSE reviewed Serine/arginine repetitive matrix protein 2 Srrm2 Kiaa0324 Mus musculus (Mouse) 2703 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0006397; GO:0008380; GO:0015030; GO:0016607; GO:0044822; GO:0071013 0 0 0 PF08312; Q8BTM8 CHOYP_LOC100369791.2.2 m.63879 sp FLNA_MOUSE 29.862 509 319 12 354 842 1866 2356 6.22E-49 192 FLNA_MOUSE reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin) Flna Fln Fln1 Mus musculus (Mouse) 2647 "actin crosslink formation [GO:0051764]; actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; cell-cell junction organization [GO:0045216]; cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; early endosome to late endosome transport [GO:0045022]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization [GO:0045184]; heart morphogenesis [GO:0003007]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase I promoter [GO:0016479]; platelet aggregation [GO:0070527]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein localization to cell surface [GO:0034394]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; wound healing, spreading of cells [GO:0044319]" GO:0001525; GO:0001664; GO:0001837; GO:0001948; GO:0001974; GO:0003007; GO:0003779; GO:0004871; GO:0005080; GO:0005634; GO:0005730; GO:0005737; GO:0005802; GO:0005829; GO:0005886; GO:0005903; GO:0005911; GO:0005925; GO:0005938; GO:0007195; GO:0008134; GO:0010977; GO:0015629; GO:0016020; GO:0016479; GO:0017048; GO:0017160; GO:0019900; GO:0030036; GO:0030334; GO:0030426; GO:0031267; GO:0031523; GO:0031532; GO:0032231; GO:0032432; GO:0034394; GO:0034988; GO:0042177; GO:0042384; GO:0042803; GO:0042993; GO:0043066; GO:0043113; GO:0043123; GO:0043433; GO:0044319; GO:0044822; GO:0045022; GO:0045184; GO:0045216; GO:0048365; GO:0050821; GO:0051015; GO:0051020; GO:0051220; GO:0051764; GO:0070062; GO:0070527; GO:0071526; GO:0090307; GO:1900026; GO:2001046 0 0 0 PF00307;PF00630; Q8C8R3 CHOYP_LOC100767295.1.1 m.31295 sp ANK2_MOUSE 30.531 226 138 4 223 448 566 772 6.22E-25 112 ANK2_MOUSE reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) Ank2 Mus musculus (Mouse) 3898 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; cardiac muscle contraction [GO:0060048]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cation channel activity [GO:2001257]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of SA node cell action potential [GO:0098907]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; T-tubule organization [GO:0033292] GO:0002027; GO:0005622; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0006874; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014069; GO:0014704; GO:0015459; GO:0016324; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0048471; GO:0050821; GO:0051117; GO:0051924; GO:0051928; GO:0055117; GO:0060048; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086014; GO:0086015; GO:0086036; GO:0086066; GO:0086070; GO:0086091; GO:0098904; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001257; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q9QX47 CHOYP_LOC100542052.2.2 m.62095 sp SON_MOUSE 58.537 123 51 0 26 148 2313 2435 6.22E-46 164 SON_MOUSE reviewed Protein SON (Negative regulatory element-binding protein) (NRE-binding protein) Son Nrebp Mus musculus (Mouse) 2444 "microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000226; GO:0000281; GO:0003677; GO:0003723; GO:0005654; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0016607; GO:0043066; GO:0043484; GO:0044822; GO:0048024; GO:0050733; GO:0051726; GO:0071011 0 0 0 PF01585; A0JM12 CHOYP_MEG10.61.91 m.50119 sp MEG10_XENTR 36.97 330 180 15 2 324 542 850 6.23E-45 169 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; A2A8L5 CHOYP_PTPRJ.1.2 m.35850 sp PTPRF_MOUSE 23.614 487 319 17 246 723 544 986 6.23E-12 73.6 PTPRF_MOUSE reviewed Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) Ptprf Lar Mus musculus (Mouse) 1898 cell adhesion [GO:0007155]; cell migration [GO:0016477]; negative regulation of receptor binding [GO:1900121]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; regulation of neuron projection development [GO:0010975] GO:0004721; GO:0004725; GO:0007155; GO:0008201; GO:0010975; GO:0016021; GO:0016477; GO:0031102; GO:0032403; GO:0035335; GO:0035373; GO:0043005; GO:0043025; GO:0048679; GO:0070062; GO:1900121 0 0 0 PF00041;PF07679;PF00102; B2RU80 CHOYP_LOC663785.2.3 m.45347 sp PTPRB_MOUSE 40.86 186 96 5 767 946 1620 1797 6.23E-31 135 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; D2GXS7 CHOYP_BRAFLDRAFT_241726.19.22 m.47315 sp TRIM2_AILME 23.922 255 180 5 124 366 492 744 6.23E-13 73.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15118 CHOYP_NEMVEDRAFT_V1G199749.1.1 m.63005 sp NPC1_HUMAN 29.086 722 433 21 221 869 556 1271 6.23E-72 263 NPC1_HUMAN reviewed Niemann-Pick C1 protein NPC1 Homo sapiens (Human) 1278 adult walking behavior [GO:0007628]; autophagy [GO:0006914]; bile acid metabolic process [GO:0008206]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to steroid hormone stimulus [GO:0071383]; cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; establishment of protein localization to membrane [GO:0090150]; lysosomal transport [GO:0007041]; membrane raft organization [GO:0031579]; negative regulation of cell death [GO:0060548]; negative regulation of macroautophagy [GO:0016242]; positive regulation of cholesterol homeostasis [GO:2000189]; protein glycosylation [GO:0006486]; response to cadmium ion [GO:0046686]; response to drug [GO:0042493]; viral entry into host cell [GO:0046718] GO:0001618; GO:0004872; GO:0004888; GO:0005576; GO:0005635; GO:0005764; GO:0005765; GO:0005783; GO:0005794; GO:0005887; GO:0006486; GO:0006897; GO:0006914; GO:0007041; GO:0007628; GO:0008203; GO:0008206; GO:0015248; GO:0015485; GO:0016020; GO:0016021; GO:0016242; GO:0030301; GO:0031579; GO:0031902; GO:0033344; GO:0042493; GO:0042632; GO:0045121; GO:0046686; GO:0046718; GO:0048471; GO:0060548; GO:0070062; GO:0071383; GO:0071404; GO:0090150; GO:2000189 0 0 0 PF16414;PF02460;PF12349; O70583 CHOYP_TRI18.2.6 m.7615 sp TRI18_MOUSE 29.051 506 299 15 42 513 4 483 6.23E-48 182 TRI18_MOUSE reviewed E3 ubiquitin-protein ligase Midline-1 (EC 6.3.2.-) (Midin) (RING finger protein Midline-1) (Tripartite motif-containing protein 18) Mid1 Fxy Trim18 Mus musculus (Mouse) 680 negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein localization to microtubule [GO:0035372] GO:0005737; GO:0005874; GO:0005881; GO:0007026; GO:0008017; GO:0008270; GO:0015630; GO:0016874; GO:0031625; GO:0032874; GO:0035372; GO:0042802; GO:0042803; GO:0046982; GO:0051219 0 0 0 PF00041;PF13765;PF00622;PF00643;PF13445; O77564 CHOYP_NALDL.1.1 m.56738 sp FOLH1_PIG 22.51 773 463 31 37 711 16 750 6.23E-32 136 FOLH1_PIG reviewed Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen homolog) (Pteroylpoly-gamma-glutamate carboxypeptidase) FOLH1 NAALAD1 Sus scrofa (Pig) 751 0 GO:0004180; GO:0005886; GO:0008237; GO:0016021; GO:0016805; GO:0046872 0 0 0 PF02225;PF04389;PF04253; P00773 CHOYP_CELA1.1.3 m.14531 sp CELA1_RAT 36.614 254 144 9 32 274 15 262 6.23E-45 155 CELA1_RAT reviewed Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) Cela1 Ela1 Rattus norvegicus (Rat) 266 0 GO:0004252; GO:0005615; GO:0046872 0 0 cd00190; PF00089; P26652 CHOYP_LOC753828.1.1 m.40149 sp TIMP3_CHICK 32.105 190 109 8 20 205 22 195 6.23E-19 84.7 TIMP3_CHICK reviewed Metalloproteinase inhibitor 3 (21 kDa protein of extracellular matrix) (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 IMP-3 Gallus gallus (Chicken) 212 negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; response to organic substance [GO:0010033] GO:0002020; GO:0005578; GO:0005615; GO:0008191; GO:0010033; GO:0043086; GO:0046872; GO:0051045 0 0 0 PF00965; P31422 CHOYP_GRM3.2.2 m.43853 sp GRM3_RAT 49.805 512 242 7 1 504 101 605 6.23E-176 520 GRM3_RAT reviewed Metabotropic glutamate receptor 3 (mGluR3) Grm3 Gprc1c Mglur3 Rattus norvegicus (Rat) 879 "modulation of synaptic transmission [GO:0050804]; regulation of synaptic transmission, glutamatergic [GO:0051966]; sensory perception of pain [GO:0019233]" GO:0001641; GO:0005887; GO:0019233; GO:0042734; GO:0050804; GO:0051966; GO:0097449 0 0 0 PF00003;PF01094;PF07562; P32192 CHOYP_LOC100117276.1.1 m.37740 sp EF1D_ARTSA 52.555 137 58 2 24 160 60 189 6.23E-40 137 EF1D_ARTSA reviewed Elongation factor 1-delta (EF-1-delta) 0 Artemia salina (Brine shrimp) 237 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; Q02357 CHOYP_LOC577492.1.1 m.47275 sp ANK1_MOUSE 37.572 173 108 0 1 173 222 394 6.23E-31 120 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q09621 CHOYP_LOC575771.2.3 m.27055 sp LACT2_CAEEL 31.095 402 249 8 24 409 66 455 6.23E-61 208 LACT2_CAEEL reviewed Beta-lactamase domain-containing protein 2 lact-2 ZK945.1 Caenorhabditis elegans 473 0 GO:0016021 0 0 0 PF00144; Q5R941 CHOYP_LOC659512.4.4 m.31246 sp FKB14_PONAB 44.749 219 107 7 9 221 1 211 6.23E-52 169 FKB14_PONAB reviewed Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase) FKBP14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 211 protein folding [GO:0006457] GO:0003755; GO:0005509; GO:0005788; GO:0006457 0 0 0 PF13499;PF00254; Q6P3Z3 CHOYP_BRAFLDRAFT_201218.1.1 m.10840 sp THAP4_MOUSE 44.262 61 32 2 9 68 1 60 6.23E-08 56.6 THAP4_MOUSE reviewed THAP domain-containing protein 4 Thap4 Mus musculus (Mouse) 569 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q8N2M8 CHOYP_CLASR.2.2 m.63780 sp CLASR_HUMAN 56.934 137 54 2 10 142 203 338 6.23E-28 112 CLASR_HUMAN reviewed "CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)" CLASRP SFRS16 SWAP2 UNQ2428/PRO4988 Homo sapiens (Human) 674 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005634; GO:0006397; GO:0008380 0 0 0 PF09750; Q95108 CHOYP_LOC100024935.1.1 m.2615 sp THIOM_BOVIN 44.604 139 75 1 32 170 29 165 6.23E-43 143 THIOM_BOVIN reviewed "Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)" TXN2 Bos taurus (Bovine) 166 cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; oxidation-reduction process [GO:0055114]; protein folding [GO:0006457]; sulfate assimilation [GO:0000103] GO:0000103; GO:0005730; GO:0005737; GO:0005739; GO:0006457; GO:0006662; GO:0015035; GO:0016671; GO:0034599; GO:0045454; GO:0055114 0 0 0 PF00085; Q9ESN6 CHOYP_BRAFLDRAFT_84666.1.3 m.13245 sp TRIM2_MOUSE 24 275 172 10 79 333 485 742 6.23E-07 54.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HCJ0 CHOYP_TNRC6A.2.2 m.59802 sp TNR6C_HUMAN 28.499 793 397 32 692 1395 884 1595 6.23E-44 179 TNR6C_HUMAN reviewed Trinucleotide repeat-containing gene 6C protein TNRC6C KIAA1582 Homo sapiens (Human) 1690 "gene silencing by miRNA [GO:0035195]; miRNA mediated inhibition of translation [GO:0035278]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; posttranscriptional gene silencing by RNA [GO:0035194]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]" GO:0000166; GO:0003723; GO:0005829; GO:0007223; GO:0035194; GO:0035195; GO:0035278; GO:0048015; GO:0060213; GO:1900153 0 0 0 PF10427;PF12938;PF00076;PF16608;PF00627; Q9NQ86 CHOYP_BRAFLDRAFT_109857.5.15 m.20479 sp TRI36_HUMAN 31.959 97 62 1 7 99 171 267 6.23E-06 52.4 TRI36_HUMAN reviewed E3 ubiquitin-protein ligase TRIM36 (EC 6.3.2.-) (RING finger protein 98) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) TRIM36 RBCC728 RNF98 Homo sapiens (Human) 728 acrosome reaction [GO:0007340]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726] GO:0000209; GO:0001669; GO:0004842; GO:0005829; GO:0005856; GO:0007340; GO:0008270; GO:0016874; GO:0051726; GO:0070062 0 0 0 PF00041;PF00643;PF13445; Q9NZN5 CHOYP_LOC100644321.6.7 m.56495 sp ARHGC_HUMAN 43.702 389 201 8 780 1153 755 1140 6.23E-80 296 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q9Y345 CHOYP_LOC100368611.1.1 m.700 sp SC6A5_HUMAN 43.886 597 323 6 10 595 177 772 6.23E-177 525 SC6A5_HUMAN reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (Solute carrier family 6 member 5) SLC6A5 GLYT2 NET1 Homo sapiens (Human) 797 "chemical synaptic transmission [GO:0007268]; glycine import [GO:0036233]; synaptic transmission, glycinergic [GO:0060012]; transport [GO:0006810]" GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0007268; GO:0015375; GO:0016021; GO:0036233; GO:0046872; GO:0060012 0 0 0 PF00209; D2GXS7 CHOYP_LOC100369333.2.32 m.3937 sp TRIM2_AILME 25.373 201 144 3 67 263 546 744 6.24E-12 68.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_87336.4.9 m.23926 sp TRIM3_RAT 26.829 123 85 3 95 213 622 743 6.24E-07 53.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P35556 CHOYP_LOC100637925.2.4 m.39170 sp FBN2_HUMAN 29.577 1606 852 66 1522 2989 1385 2849 6.24E-116 418 FBN2_HUMAN reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] FBN2 Homo sapiens (Human) 2912 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cellular response to growth factor stimulus [GO:0090287]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0022617; GO:0030023; GO:0030198; GO:0030326; GO:0030501; GO:0031012; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346; GO:0090287 0 0 0 PF12662;PF07645;PF12661;PF00683; P70684 CHOYP_PGDH.2.5 m.23073 sp PGDH_CAVPO 38.843 121 70 1 1 117 134 254 6.24E-22 90.5 PGDH_CAVPO reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) HPGD PGDH1 Cavia porcellus (Guinea pig) 265 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q01484 CHOYP_LOC755521.13.28 m.41303 sp ANK2_HUMAN 32.07 343 210 5 387 708 115 455 6.24E-40 162 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q04757 CHOYP_ISCW_ISCW017709.1.1 m.30040 sp HR29_HALRO 39.56 91 51 1 134 220 156 246 6.24E-16 77.4 HR29_HALRO reviewed Body wall muscle protein HR-29 0 Halocynthia roretzi (Sea squirt) (Cynthia roretzi) 252 0 GO:0016020 0 0 0 PF00011; Q3ZBG9 CHOYP_contig_005547 m.6297 sp PLS2_BOVIN 57.706 279 107 6 14 283 12 288 6.24E-104 308 PLS2_BOVIN reviewed Phospholipid scramblase 2 (PL scramblase 2) (Ca(2+)-dependent phospholipid scramblase 2) PLSCR2 Bos taurus (Bovine) 293 0 GO:0005886; GO:0016021; GO:0017128; GO:0046872 0 0 0 PF03803; Q66IH2 CHOYP_LOC100708602.1.1 m.65805 sp TBRG1_XENTR 40 315 184 3 125 436 34 346 6.24E-69 228 TBRG1_XENTR reviewed Transforming growth factor beta regulator 1 tbrg1 TEgg020g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 409 cell cycle [GO:0007049] GO:0005634; GO:0007049 0 0 0 PF05965;PF05964; Q6PA06 CHOYP_ATLA3.1.2 m.3861 sp ATLA2_MOUSE 38.67 406 246 2 13 418 61 463 6.24E-101 315 ATLA2_MOUSE reviewed Atlastin-2 (EC 3.6.5.-) (ADP-ribosylation factor-like protein 6-interacting protein 2) (ARL-6-interacting protein 2) (Aip-2) Atl2 Arl6ip2 Mus musculus (Mouse) 583 endoplasmic reticulum organization [GO:0007029]; Golgi organization [GO:0007030]; protein homooligomerization [GO:0051260] GO:0003924; GO:0005525; GO:0005783; GO:0005789; GO:0007029; GO:0007030; GO:0016020; GO:0016021; GO:0042802; GO:0051260 0 0 0 PF02263; Q8C0P7 CHOYP_ZN451.1.1 m.18677 sp ZN451_MOUSE 25.789 190 114 6 183 366 168 336 6.24E-09 62 ZN451_MOUSE reviewed E3 SUMO-protein ligase ZNF451 (Zinc finger protein 451) (EC 6.3.2.-) Znf451 Zfp451 Mus musculus (Mouse) 1056 "negative regulation of histone H3-K9 acetylation [GO:2000616]; negative regulation of transcription initiation from RNA polymerase II promoter [GO:0060633]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein sumoylation [GO:0016925]; transcription, DNA-templated [GO:0006351]" GO:0001106; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0016605; GO:0016874; GO:0016925; GO:0030512; GO:0046872; GO:0060633; GO:0061665; GO:2000616 PATHWAY: Protein modification; protein sumoylation. {ECO:0000269|PubMed:26524493}. 0 0 0 Q8NF37 CHOYP_LOC100120270.1.1 m.65968 sp PCAT1_HUMAN 53.77 305 140 1 13 317 23 326 6.24E-116 348 PCAT1_HUMAN reviewed Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3) LPCAT1 AYTL2 PFAAP3 Homo sapiens (Human) 534 negative regulation of phosphatidylcholine biosynthetic process [GO:2001246]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]; positive regulation of protein catabolic process [GO:0045732]; retina development in camera-type eye [GO:0060041]; surfactant homeostasis [GO:0043129]; triglyceride biosynthetic process [GO:0019432] GO:0000139; GO:0003841; GO:0005509; GO:0005783; GO:0005789; GO:0005794; GO:0005811; GO:0006654; GO:0008654; GO:0016020; GO:0016021; GO:0019432; GO:0036148; GO:0036151; GO:0043129; GO:0045732; GO:0047144; GO:0047159; GO:0047184; GO:0047191; GO:0047192; GO:0060041; GO:2001246 PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:21498505}. 0 0 PF01553;PF13833; Q96A56 CHOYP_LOC100704237.1.2 m.6766 sp T53I1_HUMAN 29.518 166 98 8 24 181 85 239 6.24E-07 51.2 T53I1_HUMAN reviewed Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) TP53INP1 P53DINP1 SIP Homo sapiens (Human) 240 "apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cell cycle arrest [GO:0007050]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of apoptotic process [GO:0042981]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to heat [GO:0009408]; response to stress [GO:0006950]; transcription, DNA-templated [GO:0006351]" GO:0000045; GO:0005634; GO:0005654; GO:0005737; GO:0005776; GO:0005829; GO:0006351; GO:0006915; GO:0006950; GO:0007050; GO:0008285; GO:0009408; GO:0010508; GO:0016209; GO:0016605; GO:0030336; GO:0031410; GO:0034644; GO:0042981; GO:0045893; GO:0048102; GO:0071361; GO:0071447; GO:0072703; GO:1901796; GO:2001235 0 0 0 PF14839; Q9DBL7 CHOYP_LOC100490454.1.1 m.64455 sp COASY_MOUSE 39.506 567 296 8 1 534 3 555 6.24E-131 395 COASY_MOUSE reviewed Bifunctional coenzyme A synthase (CoA synthase) [Includes: Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT); Dephospho-CoA kinase (DPCK) (EC 2.7.1.24) (Dephosphocoenzyme A kinase) (DPCOAK)] Coasy Ukr1 Mus musculus (Mouse) 563 coenzyme A biosynthetic process [GO:0015937] GO:0004140; GO:0004595; GO:0005524; GO:0005654; GO:0005737; GO:0005759; GO:0015937; GO:0070062 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.; PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. 0 cd02022; PF01121;PF01467; Q9Y251 CHOYP_HPSE.1.1 m.51248 sp HPSE_HUMAN 35.225 511 276 13 40 501 38 542 6.24E-87 280 HPSE_HUMAN reviewed Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) 543 angiogenesis involved in wound healing [GO:0060055]; carbohydrate metabolic process [GO:0005975]; cell-matrix adhesion [GO:0007160]; extracellular matrix organization [GO:0030198]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; positive regulation of blood coagulation [GO:0030194]; positive regulation of hair follicle development [GO:0051798]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of vascular endothelial growth factor production [GO:0010575]; proteoglycan metabolic process [GO:0006029]; regulation of hair follicle development [GO:0051797]; vascular wound healing [GO:0061042] GO:0004566; GO:0005578; GO:0005634; GO:0005654; GO:0005764; GO:0005765; GO:0005975; GO:0006027; GO:0006029; GO:0007160; GO:0010575; GO:0030194; GO:0030198; GO:0030200; GO:0030305; GO:0033690; GO:0043202; GO:0043231; GO:0043395; GO:0045121; GO:0045545; GO:0046983; GO:0051797; GO:0051798; GO:0051897; GO:0060055; GO:0061042 0 0 0 PF03662; D2GXS7 CHOYP_LOC100374741.9.83 m.11119 sp TRIM2_AILME 21.843 293 205 6 117 392 453 738 6.25E-09 61.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5E8K5 CHOYP_AAEL_AAEL014668.2.2 m.28431 sp ANK3_MOUSE 29.511 532 341 11 1 511 280 798 6.25E-50 189 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O43312 CHOYP_MTSS1.1.5 m.732 sp MTSS1_HUMAN 63.082 279 99 1 1 279 1 275 6.25E-118 376 MTSS1_HUMAN reviewed Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) 755 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; movement of cell or subcellular component [GO:0006928]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of defense response to virus by host [GO:0002230]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; xenophagy [GO:0098792] GO:0001726; GO:0002230; GO:0003785; GO:0005102; GO:0005737; GO:0006928; GO:0007009; GO:0007155; GO:0007169; GO:0015629; GO:0030035; GO:0030036; GO:0030139; GO:0042802; GO:0050680; GO:0061333; GO:0071498; GO:0072102; GO:0072160; GO:0098792; GO:2001013 0 0 0 PF08397;PF02205; P54353 CHOYP_IF4A2.1.1 m.62722 sp DOD_DROME 63.19 163 49 1 2 153 4 166 6.25E-68 206 DOD_DROME reviewed Putative peptidyl-prolyl cis-trans isomerase dodo (PPIase dodo) (EC 5.2.1.8) (Rotamase dodo) dod CG17051 Drosophila melanogaster (Fruit fly) 166 epidermal growth factor receptor signaling pathway [GO:0007173] GO:0003755; GO:0005634; GO:0007173 0 0 0 PF00639;PF00397; Q3UV71 CHOYP_TMTC1.1.1 m.9406 sp TMTC1_MOUSE 39.028 597 356 4 3 596 341 932 6.25E-135 420 TMTC1_MOUSE reviewed Transmembrane and TPR repeat-containing protein 1 Tmtc1 Mus musculus (Mouse) 942 RNA processing [GO:0006396] GO:0005739; GO:0006396; GO:0016021 0 0 0 PF08409;PF13414; Q66IL0 CHOYP_LOC100544553.1.1 m.13028 sp CHID1_XENTR 53.944 393 170 6 3 386 4 394 6.25E-147 424 CHID1_XENTR reviewed Chitinase domain-containing protein 1 chid1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 394 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; inflammatory response [GO:0006954] GO:0004568; GO:0005576; GO:0005764; GO:0005975; GO:0006032; GO:0006954; GO:0008061 0 0 0 PF00704; Q6DCS1 CHOYP_LYRM4.2.3 m.7011 sp LYRM4_XENLA 52.439 82 39 0 2 83 4 85 6.25E-26 95.1 LYRM4_XENLA reviewed LYR motif-containing protein 4 lyrm4 isd11 Xenopus laevis (African clawed frog) 89 0 GO:0005634; GO:0005739 PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. 0 0 PF05347; Q6GQ70 CHOYP_S35B1.1.1 m.9746 sp S35B1_XENLA 60.577 312 119 2 35 344 7 316 6.25E-124 362 S35B1_XENLA reviewed Solute carrier family 35 member B1 (Endoplasmic reticulum nucleotide sugar transporter 1) slc35b1 ernst1 Xenopus laevis (African clawed frog) 320 carbohydrate transport [GO:0008643]; transmembrane transport [GO:0055085] GO:0005789; GO:0008643; GO:0016021; GO:0055085 0 0 0 PF08449; Q88SK6 CHOYP_LMXM_36_6480.1.2 m.33817 sp Y3408_LACPL 30.539 167 107 4 1236 1398 2 163 6.25E-13 72.4 Y3408_LACPL reviewed Macro domain-containing protein lp_3408 lp_3408 Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 172 0 0 0 0 0 PF01661; Q8IZN3 CHOYP_ZDH14.1.2 m.12296 sp ZDH14_HUMAN 73.927 303 78 1 41 342 40 342 6.25E-173 496 ZDH14_HUMAN reviewed Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) ZDHHC14 Homo sapiens (Human) 488 protein palmitoylation [GO:0018345] GO:0005783; GO:0008270; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q8NUZ4 CHOYP_LOC100891431.1.1 m.44197 sp FLP_STAAW 25 320 183 11 38 347 58 330 6.25E-09 62.4 FLP_STAAW reviewed Protein flp (FmtA-like protein) flp MW2365 Staphylococcus aureus (strain MW2) 498 0 GO:0005886; GO:0016021 0 0 0 PF00144; Q96GX1 CHOYP_LOC100891343.1.1 m.13382 sp TECT2_HUMAN 23.989 371 219 11 475 838 357 671 6.25E-26 117 TECT2_HUMAN reviewed Tectonic-2 TCTN2 C12orf38 TECT2 Homo sapiens (Human) 697 cilium assembly [GO:0042384]; cilium morphogenesis [GO:0060271]; smoothened signaling pathway [GO:0007224] GO:0005737; GO:0005856; GO:0007224; GO:0016021; GO:0036038; GO:0042384; GO:0060170; GO:0060271 0 0 0 PF07773; Q9GUM2 CHOYP_LOC100121931.1.1 m.5977 sp BRE4_CAEEL 44.815 270 144 3 104 369 96 364 6.25E-82 258 BRE4_CAEEL reviewed "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 Y73E7A.7 Caenorhabditis elegans 383 formation of infection structure on or near host [GO:0075015]; positive regulation of Notch signaling pathway [GO:0045747]; protein glycosylation [GO:0006486]; response to toxic substance [GO:0009636] GO:0006486; GO:0008376; GO:0009636; GO:0016021; GO:0033207; GO:0045747; GO:0046872; GO:0075015 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:12167666, ECO:0000269|PubMed:12944392}." 0 0 PF02709;PF13733; Q9R172 CHOYP_BRAFLDRAFT_89746.1.2 m.29425 sp NOTC3_RAT 45.37 108 57 1 4 111 170 275 6.25E-26 116 NOTC3_RAT reviewed Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Notch3 Rattus norvegicus (Rat) 2319 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; Notch signaling pathway [GO:0007219]; regulation of transcription, DNA-templated [GO:0006355]; tissue regeneration [GO:0042246]; transcription, DNA-templated [GO:0006351]" GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0007219; GO:0007275; GO:0016021; GO:0030154; GO:0042246 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P06603 CHOYP_TBA3E.1.1 m.4874 sp TBA1_DROME 91.111 180 10 1 11 190 54 227 6.26E-113 333 TBA1_DROME reviewed Tubulin alpha-1 chain alphaTub84B tubA84B CG1913 Drosophila melanogaster (Fruit fly) 450 antimicrobial humoral response [GO:0019730]; microtubule-based process [GO:0007017]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052] GO:0000235; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0007017; GO:0007052; GO:0007094; GO:0019730; GO:0048471 0 0 0 PF00091;PF03953; P34059 CHOYP_LOC588014.1.1 m.62735 sp GALNS_HUMAN 83.962 106 17 0 20 125 31 136 6.26E-58 191 GALNS_HUMAN reviewed N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase) GALNS Homo sapiens (Human) 522 keratan sulfate catabolic process [GO:0042340] GO:0003943; GO:0008484; GO:0042340; GO:0043202; GO:0043890; GO:0046872; GO:0070062 0 0 0 PF00884; P83425 CHOYP_BRAFLDRAFT_69134.12.13 m.65262 sp HIP_MYTED 30.973 113 75 2 50 161 85 195 6.26E-11 62 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q2NL00 CHOYP_LOC100166353.1.1 m.4625 sp GSTT1_BOVIN 42.922 219 122 3 4 221 3 219 6.26E-61 194 GSTT1_BOVIN reviewed Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) GSTT1 Bos taurus (Bovine) 240 glutathione metabolic process [GO:0006749] GO:0004364; GO:0005737; GO:0006749 0 0 0 PF00043;PF02798; Q4V885 CHOYP_LOC100699850.3.3 m.52775 sp COL12_RAT 33.077 130 77 5 106 229 606 731 6.26E-15 77 COL12_RAT reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) (Nurse cell scavenger receptor 2) Colec12 Clp1 Nsr2 Rattus norvegicus (Rat) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; Q66S03 CHOYP_LECM2.2.3 m.55809 sp LECG_THANI 29.655 145 100 2 5 148 12 155 6.26E-17 75.9 LECG_THANI reviewed Galactose-specific lectin nattectin (CTL) 0 Thalassophryne nattereri (Niquim) 159 inflammatory response [GO:0006954] GO:0005576; GO:0006954; GO:0030246; GO:0046872 0 0 0 PF00059; Q6ZPS2 CHOYP_CRNS1.1.1 m.65329 sp CRNS1_MOUSE 38.857 175 104 2 19 192 406 578 6.26E-31 121 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q7Z9I4 CHOYP_LOC100561086.1.1 m.13015 sp YCP6_SCHPO 31.128 257 147 5 8 246 9 253 6.26E-29 112 YCP6_SCHPO reviewed Uncharacterized oxidoreductase C663.06c (EC 1.-.-.-) SPCC663.06c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 253 0 GO:0005634; GO:0005829; GO:0016491 0 0 0 PF00106; Q96MM6 CHOYP_BRAFLDRAFT_208436.28.32 m.61328 sp HS12B_HUMAN 32.357 649 371 12 1 584 41 686 6.26E-107 339 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96RW7 CHOYP_HMCN1.36.44 m.60553 sp HMCN1_HUMAN 20.978 491 326 14 55 494 2691 3170 6.26E-18 92 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99N01 CHOYP_SLCO4A1.4.4 m.42697 sp SO4A1_RAT 38.235 102 63 0 41 142 81 182 6.26E-18 82.4 SO4A1_RAT reviewed Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Rattus norvegicus (Rat) 723 sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403] GO:0005887; GO:0015347; GO:0015349; GO:0042403; GO:0043252 0 0 cd06174; PF07648;PF03137; Q9CR23 CHOYP_AGAP_AGAP007259.1.1 m.54356 sp TMEM9_MOUSE 37.43 179 95 5 34 207 17 183 6.26E-30 112 TMEM9_MOUSE reviewed Transmembrane protein 9 Tmem9 Mus musculus (Mouse) 183 transport [GO:0006810] GO:0005764; GO:0005765; GO:0005770; GO:0006810; GO:0016021; GO:0031902 0 0 0 PF05434; Q9ULJ7 CHOYP_AASI_1435.7.35 m.32828 sp ANR50_HUMAN 36.842 380 219 4 56 414 528 907 6.26E-57 206 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9XYM0 CHOYP_PHUM_PHUM332570.1.1 m.56283 sp CRK_DROME 50.192 261 115 4 5 254 4 260 6.26E-88 265 CRK_DROME reviewed Adapter molecule Crk Crk CG1587 Drosophila melanogaster (Fruit fly) 271 "border follicle cell migration [GO:0007298]; ephrin receptor signaling pathway [GO:0048013]; imaginal disc fusion, thorax closure [GO:0046529]; myoblast fusion [GO:0007520]; phagocytosis, engulfment [GO:0006911]; positive regulation of JNK cascade [GO:0046330]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of GTPase activity [GO:0043087]" GO:0005070; GO:0006911; GO:0007298; GO:0007520; GO:0032956; GO:0043087; GO:0046330; GO:0046529; GO:0048013 0 0 0 PF00017;PF00018;PF07653; A7RWC9 CHOYP_ITPA.1.1 m.13655 sp ITPA_NEMVE 66.484 182 61 0 26 207 4 185 6.27E-89 263 ITPA_NEMVE reviewed Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.19) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) v1g163483 Nematostella vectensis (Starlet sea anemone) 203 deoxyribonucleoside triphosphate catabolic process [GO:0009204]; nucleotide metabolic process [GO:0009117] GO:0000166; GO:0005737; GO:0009117; GO:0009204; GO:0046872; GO:0047429 0 0 cd00515; PF01725; D2GXS7 CHOYP_TRIM2.20.59 m.32887 sp TRIM2_AILME 29.268 164 102 8 112 270 536 690 6.27E-07 53.9 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O18739 CHOYP_CYR61.1.1 m.33530 sp CTGF_BOVIN 35 320 189 8 37 348 22 330 6.27E-51 176 CTGF_BOVIN reviewed Connective tissue growth factor (CCN family member 2) CTGF CCN2 Bos taurus (Bovine) 349 angiogenesis [GO:0001525]; cartilage condensation [GO:0001502]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell differentiation [GO:0030154]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; chondrocyte proliferation [GO:0035988]; DNA biosynthetic process [GO:0071897]; fibroblast growth factor receptor signaling pathway [GO:0008543]; integrin-mediated signaling pathway [GO:0007229]; lung development [GO:0030324]; negative regulation of cell death [GO:0060548]; negative regulation of gene expression [GO:0010629]; ossification [GO:0001503]; positive regulation of cell differentiation [GO:0045597]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of stress fiber assembly [GO:0051496]; reactive oxygen species metabolic process [GO:0072593]; regulation of cell growth [GO:0001558]; regulation of chondrocyte differentiation [GO:0032330]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894] GO:0001502; GO:0001503; GO:0001525; GO:0001558; GO:0001894; GO:0005178; GO:0005578; GO:0005794; GO:0007155; GO:0007160; GO:0007165; GO:0007229; GO:0007267; GO:0008201; GO:0008543; GO:0010629; GO:0016477; GO:0030154; GO:0030324; GO:0032330; GO:0035988; GO:0045597; GO:0046330; GO:0051496; GO:0060548; GO:0070374; GO:0071897; GO:0072593 0 0 0 PF00007;PF00219;PF00090;PF00093; O70277 CHOYP_TRIM3.4.58 m.3384 sp TRIM3_RAT 27.315 216 143 7 22 231 536 743 6.27E-11 65.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_LOC581927.4.27 m.14275 sp ANR17_HUMAN 34.857 350 214 10 23 360 241 588 6.27E-46 171 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O88488 CHOYP_PHUM_PHUM530510.1.1 m.42208 sp PTPRQ_RAT 27.258 1218 725 34 683 1838 1146 2264 6.27E-95 346 PTPRQ_RAT reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1) (rPTP-GMC1) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Ptpgmc1 Rattus norvegicus (Rat) 2302 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0005886; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; P86854 CHOYP_CLC4E.1.1 m.15210 sp PLCL_MYTGA 26.946 167 106 6 2 163 1 156 6.27E-15 71.6 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q17M80 CHOYP_MMSA.1.2 m.13168 sp MMSA_AEDAE 74 250 65 0 11 260 7 256 6.27E-137 398 MMSA_AEDAE reviewed "Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27)" AAEL001134 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 521 thymine metabolic process [GO:0019859]; valine metabolic process [GO:0006573] GO:0004491; GO:0005739; GO:0006573; GO:0018478; GO:0019859 0 0 cd07085; PF00171; Q5ZIR1 CHOYP_SHLB1.2.2 m.54016 sp SHLB1_CHICK 60.163 369 133 4 19 379 3 365 6.27E-162 461 SHLB1_CHICK reviewed Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) SH3GLB1 RCJMB04_24b23 Gallus gallus (Chicken) 366 'de novo' posttranslational protein folding [GO:0051084]; apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; phosphatidic acid biosynthetic process [GO:0006654]; phospholipid biosynthetic process [GO:0008654]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; protein localization to vacuolar membrane [GO:1903778] GO:0000139; GO:0005504; GO:0005741; GO:0006654; GO:0006915; GO:0008654; GO:0042171; GO:0043234; GO:0043552; GO:0048102; GO:0051084; GO:1900740; GO:1902254; GO:1902255; GO:1903778; GO:2000786 0 0 0 PF03114;PF14604; Q99M87 CHOYP_LOC100909243.1.1 m.22728 sp DNJA3_MOUSE 52.5 240 112 2 1 240 241 478 6.27E-87 268 DNJA3_MOUSE reviewed "DnaJ homolog subfamily A member 3, mitochondrial (DnaJ protein Tid-1) (mTid-1) (Tumorous imaginal discs protein Tid56 homolog)" Dnaja3 Tid1 Mus musculus (Mouse) 480 activation-induced cell death of T cells [GO:0006924]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cell aging [GO:0007569]; mitochondrial DNA replication [GO:0006264]; mitochondrion organization [GO:0007005]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of programmed cell death [GO:0043069]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuromuscular junction development [GO:0007528]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of T cell proliferation [GO:0042102]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; response to heat [GO:0009408]; response to interferon-gamma [GO:0034341]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; small GTPase mediated signal transduction [GO:0007264]; T cell differentiation in thymus [GO:0033077] GO:0000122; GO:0005524; GO:0005634; GO:0005739; GO:0005759; GO:0005829; GO:0005884; GO:0005886; GO:0006264; GO:0006457; GO:0006469; GO:0006915; GO:0006919; GO:0006924; GO:0007005; GO:0007264; GO:0007528; GO:0007569; GO:0008285; GO:0008385; GO:0009408; GO:0019897; GO:0030054; GO:0030695; GO:0030971; GO:0031398; GO:0031594; GO:0032088; GO:0033077; GO:0033256; GO:0034341; GO:0042102; GO:0042645; GO:0042981; GO:0043069; GO:0043124; GO:0043154; GO:0043231; GO:0045211; GO:0046872; GO:0050821; GO:0051082; GO:0060336; GO:0071340 0 0 cd06257; PF00226;PF01556;PF00684; Q9D9R9 CHOYP_contig_038255 m.43237 sp F186A_MOUSE 36.632 475 179 23 117 533 533 943 6.27E-19 95.9 F186A_MOUSE reviewed Protein FAM186A FAM186A Gm920 Mus musculus (Mouse) 1790 0 0 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_88217.14.14 m.62975 sp TRIM2_MOUSE 25.116 215 142 6 1238 1448 534 733 6.27E-11 70.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43301 CHOYP_BRAFLDRAFT_242762.4.8 m.21828 sp HS12A_HUMAN 30.216 278 176 5 1 270 315 582 6.28E-37 144 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P07572 CHOYP_LOC100489555.1.1 m.51823 sp POL_MPMV 28.718 195 107 9 111 292 69 244 6.28E-06 52.8 POL_MPMV reviewed Pol polyprotein [Cleaved into: Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] pol Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus) 867 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006310; GO:0008270; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00552;PF02022;PF00075;PF00665;PF00078;PF06817; P17078 CHOYP_LOC100209196.1.1 m.21584 sp RL35_RAT 72.321 112 31 0 1 112 1 112 6.28E-48 152 RL35_RAT reviewed 60S ribosomal protein L35 Rpl35 Rattus norvegicus (Rat) 123 "cellular response to UV-B [GO:0071493]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; translation [GO:0006412]" GO:0000463; GO:0003729; GO:0003735; GO:0006412; GO:0022625; GO:0043021; GO:0071493 0 0 cd00427; PF00831; Q02357 CHOYP_PERMA_0371.1.1 m.54922 sp ANK1_MOUSE 41.026 117 69 0 39 155 336 452 6.28E-21 94.4 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q32ZE2 CHOYP_MC4R.1.1 m.40134 sp AA2BR_RABIT 28.947 304 169 10 77 356 28 308 6.28E-17 84.3 AA2BR_RABIT reviewed Adenosine receptor A2b ADORA2B Oryctolagus cuniculus (Rabbit) 332 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; cellular response to extracellular stimulus [GO:0031668]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of chemokine production [GO:0032722]; positive regulation of chronic inflammatory response to non-antigenic stimulus [GO:0002882]; positive regulation of guanylate cyclase activity [GO:0031284]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of vascular endothelial growth factor production [GO:0010575]; relaxation of vascular smooth muscle [GO:0060087] GO:0001609; GO:0002882; GO:0005886; GO:0007189; GO:0010575; GO:0016021; GO:0030819; GO:0031284; GO:0031668; GO:0032722; GO:0032755; GO:0043306; GO:0060087 0 0 0 PF00001; Q3ZBG5 CHOYP_TSP_06726.1.1 m.7470 sp BAG2_BOVIN 34.161 161 105 1 33 192 18 178 6.28E-25 99.8 BAG2_BOVIN reviewed BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2) 0 Bos taurus (Bovine) 211 protein folding [GO:0006457]; protein metabolic process [GO:0019538] GO:0006457; GO:0019538 0 0 0 0 Q5M8V0 CHOYP_ISCW_ISCW006277.1.2 m.29448 sp BT3L4_XENTR 84.615 117 18 0 1 117 1 117 6.28E-67 202 BT3L4_XENTR reviewed Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) btf3l4 TNeu120e23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 158 0 0 0 0 0 PF01849; Q5PPY6 CHOYP_LOC100368639.1.1 m.56563 sp EIF3H_XENLA 61.3 323 121 3 44 365 14 333 6.28E-142 409 EIF3H_XENLA reviewed Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit) eif3h eif3s3 Xenopus laevis (African clawed frog) 334 formation of translation preinitiation complex [GO:0001731]; translational initiation [GO:0006413] GO:0001731; GO:0003743; GO:0005852; GO:0006413; GO:0016282; GO:0033290 0 0 cd08065; PF01398; Q9NUV9 CHOYP_GIMA4.3.7 m.34228 sp GIMA4_HUMAN 43.103 290 144 5 268 545 9 289 6.28E-63 213 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9Y5Z4 CHOYP_VOLCADRAFT_89567.1.1 m.27272 sp HEBP2_HUMAN 39.873 158 93 2 50 206 38 194 6.28E-28 107 HEBP2_HUMAN reviewed Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) HEBP2 C6orf34 SOUL Homo sapiens (Human) 205 negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of necrotic cell death [GO:0010940] GO:0005737; GO:0005739; GO:0010917; GO:0010940; GO:0035794; GO:0070062 0 0 0 PF04832; F4KGU4 CHOYP_LOC100632169.6.6 m.59137 sp DEAHC_ARATH 31.721 1261 763 33 6 1205 235 1458 6.29E-165 538 DEAHC_ARATH reviewed "ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)" At5g10370 F12B17_280 Arabidopsis thaliana (Mouse-ear cress) 1775 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006396; GO:0008270; GO:0009507; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF01485;PF07717;PF13445; P16157 CHOYP_TVAG_168010.32.45 m.57378 sp ANK1_HUMAN 31.026 809 519 2 185 993 5 774 6.29E-105 369 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P41924 CHOYP_PGTG_05920.1.1 m.27206 sp RYL1_YARLI 34.783 184 106 4 22 197 9 186 6.29E-32 118 RYL1_YARLI reviewed Ras-like GTP-binding protein RYL1 RYL1 YALI0E23067g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) 203 protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; small GTPase mediated signal transduction [GO:0007264]; vesicle docking involved in exocytosis [GO:0006904] GO:0005525; GO:0005768; GO:0005886; GO:0006904; GO:0007264; GO:0009306; GO:0072659 0 0 0 PF00071; Q20681 CHOYP_NEMVEDRAFT_V1G198958.3.6 m.33963 sp BAT38_CAEEL 39.583 96 56 2 18 112 229 323 6.29E-12 67.4 BAT38_CAEEL reviewed BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans 387 0 0 0 0 0 PF00651;PF00917; Q5ZMH1 CHOYP_SEPT2.1.1 m.40427 sp SEPT2_CHICK 76.226 265 61 1 253 517 3 265 6.29E-152 443 SEPT2_CHICK reviewed Septin-2 SEPT2 RCJMB04_2a21 Gallus gallus (Chicken) 349 cell division [GO:0051301]; cilium assembly [GO:0042384]; mitotic nuclear division [GO:0007067]; smoothened signaling pathway [GO:0007224] GO:0005525; GO:0005737; GO:0005819; GO:0005938; GO:0007067; GO:0007224; GO:0030496; GO:0032154; GO:0042384; GO:0051301; GO:0060170 0 0 cd01850; PF00735; Q64347 CHOYP_BRAFLDRAFT_118473.1.3 m.10905 sp CLCN1_MOUSE 41.157 605 310 7 1 600 316 879 6.29E-149 459 CLCN1_MOUSE reviewed "Chloride channel protein 1 (ClC-1) (Chloride channel protein, skeletal muscle)" Clcn1 Clc1 Mus musculus (Mouse) 994 chloride transmembrane transport [GO:1902476]; chloride transport [GO:0006821]; muscle contraction [GO:0006936]; neuronal action potential propagation [GO:0019227] GO:0005247; GO:0005887; GO:0006821; GO:0006936; GO:0019227; GO:0034707; GO:0042383; GO:0042803; GO:1902476 0 0 0 PF00654; Q71U34 CHOYP_BRAFLDRAFT_114843.2.2 m.57235 sp HSP7C_SAGOE 94.118 153 9 0 1 153 237 389 6.29E-98 298 HSP7C_SAGOE reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) (Intracellular vitamin D-binding protein 1) HSPA8 IDBP1 Saguinus oedipus (Cotton-top tamarin) 646 "mRNA processing [GO:0006397]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005681; GO:0005730; GO:0005886; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0042470 0 0 0 PF00012; Q8BN59 CHOYP_PHUM_PHUM210130.1.1 m.22260 sp LARP6_MOUSE 57.813 64 22 2 50 113 65 123 6.29E-14 69.7 LARP6_MOUSE reviewed La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) Larp6 Mus musculus (Mouse) 492 regulation of translation [GO:0006417]; RNA processing [GO:0006396] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006396; GO:0006417; GO:0030529 0 0 0 PF05383;PF12901; Q8N539 CHOYP_BRAFLDRAFT_59661.3.6 m.48775 sp FBCD1_HUMAN 49.115 226 105 3 41 256 230 455 6.29E-74 235 FBCD1_HUMAN reviewed Fibrinogen C domain-containing protein 1 FIBCD1 UNQ701/PRO1346 Homo sapiens (Human) 461 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q96RW7 CHOYP_FRED.1.1 m.55727 sp HMCN1_HUMAN 24.932 734 405 32 31 702 2879 3528 6.29E-34 146 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; A2AWP0 CHOYP_IAP1.1.4 m.25918 sp BIRC7_MOUSE 42.361 144 78 2 148 286 85 228 6.30E-30 117 BIRC7_MOUSE reviewed Baculoviral IAP repeat-containing protein 7 (EC 6.3.2.-) (Livin) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30 kDa subunit (Truncated livin) (p30-Livin) (tLivin)] Birc7 Livin Mus musculus (Mouse) 285 apoptotic process [GO:0006915]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127]; regulation of natural killer cell apoptotic process [GO:0070247]; regulation of signal transduction [GO:0009966] GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005794; GO:0005876; GO:0006915; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0042127; GO:0043066; GO:0070247; GO:0090307; GO:1990001 0 0 0 PF00653; O01159 CHOYP_LOC100370236.2.3 m.7770 sp RSP7_CAEEL 39.441 322 190 3 3 322 5 323 6.30E-50 183 RSP7_CAEEL reviewed "Probable splicing factor, arginine/serine-rich 7 (p54)" rsp-7 D2089.1 Caenorhabditis elegans 452 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005634 0 0 0 PF00076; O14463 CHOYP_RS21.1.4 m.13400 sp TRX1_SCHPO 53.922 102 47 0 1 102 1 102 6.30E-35 118 TRX1_SCHPO reviewed Thioredoxin-1 (TR-1) (Trx-1) trx1 trx2 SPAC7D4.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 103 "cell redox homeostasis [GO:0045454]; cellular response to reactive oxygen species [GO:0034614]; glycerol ether metabolic process [GO:0006662]; hydrogen peroxide catabolic process [GO:0042744]; L-methionine biosynthetic process from methionine sulphoxide [GO:1990355]; positive regulation of cellular response to oxidative stress [GO:1900409]; protein folding [GO:0006457]; sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [GO:0019379]" GO:0005634; GO:0005737; GO:0005829; GO:0006457; GO:0006662; GO:0015035; GO:0016209; GO:0016671; GO:0019379; GO:0034614; GO:0042744; GO:0045454; GO:1900409; GO:1990355 0 0 0 PF00085; O14463 CHOYP_RTJK.3.3 m.35968 sp TRX1_SCHPO 53.922 102 47 0 1 102 1 102 6.30E-35 118 TRX1_SCHPO reviewed Thioredoxin-1 (TR-1) (Trx-1) trx1 trx2 SPAC7D4.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 103 "cell redox homeostasis [GO:0045454]; cellular response to reactive oxygen species [GO:0034614]; glycerol ether metabolic process [GO:0006662]; hydrogen peroxide catabolic process [GO:0042744]; L-methionine biosynthetic process from methionine sulphoxide [GO:1990355]; positive regulation of cellular response to oxidative stress [GO:1900409]; protein folding [GO:0006457]; sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [GO:0019379]" GO:0005634; GO:0005737; GO:0005829; GO:0006457; GO:0006662; GO:0015035; GO:0016209; GO:0016671; GO:0019379; GO:0034614; GO:0042744; GO:0045454; GO:1900409; GO:1990355 0 0 0 PF00085; O28987 CHOYP_LOC100638860.2.2 m.44785 sp Y1281_ARCFU 48.503 167 85 1 25 191 2 167 6.30E-52 167 Y1281_ARCFU reviewed Uncharacterized protein AF_1281 AF_1281 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) 168 0 0 0 0 0 PF01965; O35127 CHOYP_C10.2.2 m.53993 sp C10_MOUSE 47.959 98 51 0 23 120 20 117 6.30E-29 104 C10_MOUSE reviewed Protein C10 Grcc10 C10 Mus musculus (Mouse) 126 0 GO:0005737 0 0 0 PF14974; O75095 CHOYP_MEGF10.1.12 m.1686 sp MEGF6_HUMAN 37.991 229 129 7 50 275 639 857 6.30E-35 137 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P70604 CHOYP_LOC563352.1.1 m.20403 sp KCNN2_RAT 32.921 404 259 5 43 438 117 516 6.30E-67 226 KCNN2_RAT reviewed Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) Kcnn2 Rattus norvegicus (Rat) 580 potassium ion transport [GO:0006813]; regulation of neuronal synaptic plasticity [GO:0048168] GO:0005516; GO:0005886; GO:0006813; GO:0016021; GO:0016286; GO:0043025; GO:0043197; GO:0048168 0 0 0 PF02888;PF07885;PF03530; Q14978 CHOYP_NOLC1.1.3 m.21141 sp NOLC1_HUMAN 59.292 113 40 2 732 839 588 699 6.30E-32 136 NOLC1_HUMAN reviewed Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) NOLC1 KIAA0035 NS5ATP13 Homo sapiens (Human) 699 cell cycle [GO:0007049]; mitotic nuclear division [GO:0007067]; nucleolus organization [GO:0007000]; rRNA processing [GO:0006364] GO:0005524; GO:0005525; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0007000; GO:0007049; GO:0007067; GO:0015030; GO:0044822 0 0 0 PF05022; Q2HJ10 CHOYP_LOC100123888.1.1 m.52921 sp ZNT2_MOUSE 44.828 377 151 4 28 400 46 369 6.30E-108 325 ZNT2_MOUSE reviewed Zinc transporter 2 (ZnT-2) (Solute carrier family 30 member 2) Slc30a2 Znt2 Mus musculus (Mouse) 371 positive regulation of sequestering of zinc ion [GO:0061090]; regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043] GO:0005385; GO:0005737; GO:0005765; GO:0005770; GO:0005886; GO:0010043; GO:0016021; GO:0016023; GO:0061088; GO:0061090 0 0 0 PF01545; Q4GXU6 CHOYP_RS4.5.11 m.30050 sp RS4_CARGR 73.214 56 15 0 22 77 39 94 6.30E-22 89.7 RS4_CARGR reviewed 40S ribosomal protein S4 RpS4 Carabus granulatus (Ground beetle) 261 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q502M6 CHOYP_TVAG_388180.2.8 m.13644 sp ANR29_DANRE 38.621 145 89 0 93 237 56 200 6.30E-29 113 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5F478 CHOYP_TVAG_099270.6.6 m.61151 sp ANR44_CHICK 34.583 240 136 3 548 786 45 264 6.30E-30 130 ANR44_CHICK reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 RCJMB04_2g14 Gallus gallus (Chicken) 990 0 0 0 0 0 PF00023;PF12796; Q5I2E5 CHOYP_BRAFLDRAFT_252169.4.6 m.39043 sp FCN2_BOVIN 51.087 184 80 4 201 383 121 295 6.30E-52 180 FCN2_BOVIN reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) 329 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0046872 0 0 0 PF01391;PF00147; Q5M7D6 CHOYP_LOC578003.1.1 m.64329 sp P4R2A_XENLA 50.955 157 72 3 24 179 1 153 6.30E-39 150 P4R2A_XENLA reviewed Serine/threonine-protein phosphatase 4 regulatory subunit 2-A ppp4r2-a Xenopus laevis (African clawed frog) 403 0 GO:0030289; GO:0030362 0 0 0 PF09184; Q5U4F6 CHOYP_LOC100373578.1.1 m.478 sp WDR34_MOUSE 37.278 507 303 8 4 504 38 535 6.30E-120 365 WDR34_MOUSE reviewed WD repeat-containing protein 34 Wdr34 Mus musculus (Mouse) 535 0 GO:0005737; GO:0005814; GO:0005868; GO:0005930; GO:0036064 0 0 0 PF00400; Q5ZLF0 CHOYP_F10A1.3.4 m.36004 sp F10A1_CHICK 65.217 69 23 1 33 101 294 361 6.30E-24 96.7 F10A1_CHICK reviewed Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) ST13 FAM10A1 RCJMB04_6h13 Gallus gallus (Chicken) 361 0 GO:0005737 0 0 0 PF13181; Q6NS45 CHOYP_BRAFLDRAFT_121183.8.8 m.66891 sp CCD66_MOUSE 39.098 133 81 0 637 769 438 570 6.30E-13 77 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q6P2X9 CHOYP_MOT3.1.1 m.1348 sp MOT12_XENTR 31.714 350 192 12 2 317 83 419 6.30E-28 118 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6R7H9 CHOYP_Y047.1.1 m.27088 sp Y045_OSHVF 100 241 0 0 1 241 1 241 6.30E-177 488 Y045_OSHVF reviewed Uncharacterized protein ORF45 ORF45 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 241 0 0 0 0 0 0 Q8CHB8 CHOYP_LOC100372717.1.1 m.23092 sp TTLL5_MOUSE 43.443 244 97 4 1 241 298 503 6.30E-63 215 TTLL5_MOUSE reviewed Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 5) Ttll5 Kiaa0998 Mus musculus (Mouse) 1328 "fertilization [GO:0009566]; protein polyglutamylation [GO:0018095]; retina development in camera-type eye [GO:0060041]; spermatogenesis [GO:0007283]; sperm axoneme assembly [GO:0007288]; sperm motility [GO:0030317]; transcription, DNA-templated [GO:0006351]" GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0005874; GO:0005929; GO:0006351; GO:0007283; GO:0007288; GO:0009566; GO:0016874; GO:0018095; GO:0030317; GO:0060041 0 0 0 PF03133; Q8NI99 CHOYP_LOC100698094.1.1 m.53121 sp ANGL6_HUMAN 36.792 212 126 5 34 240 257 465 6.30E-38 140 ANGL6_HUMAN reviewed Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) (Angiopoietin-related protein 5) ANGPTL6 AGF ARP5 UNQ152/PRO178 Homo sapiens (Human) 470 angiogenesis [GO:0001525]; cell differentiation [GO:0030154] GO:0001525; GO:0030141; GO:0030154; GO:0070062 0 0 0 PF00147; Q91ZT9 CHOYP_TVAG_469860.1.1 m.32462 sp ASB8_MOUSE 42.384 151 84 3 442 592 30 177 6.30E-24 105 ASB8_MOUSE reviewed Ankyrin repeat and SOCS box protein 8 (ASB-8) Asb8 Mus musculus (Mouse) 288 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005737; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q9ESN6 CHOYP_BRAFLDRAFT_88218.6.8 m.42418 sp TRIM2_MOUSE 27.895 190 128 5 188 373 536 720 6.30E-11 67.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14512 CHOYP_LOC588073.1.1 m.56436 sp SOCS7_HUMAN 52.459 183 81 2 976 1157 377 554 6.31E-60 219 SOCS7_HUMAN reviewed "Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4)" SOCS7 NAP4 SOCS6 Homo sapiens (Human) 581 cytokine-mediated signaling pathway [GO:0019221]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; intracellular signal transduction [GO:0035556]; layer formation in cerebral cortex [GO:0021819]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; protein ubiquitination [GO:0016567]; radial glia guided migration of Purkinje cell [GO:0021942]; regulation of growth [GO:0040008] GO:0004860; GO:0005634; GO:0005737; GO:0005886; GO:0006469; GO:0008286; GO:0016567; GO:0017124; GO:0019221; GO:0021819; GO:0021942; GO:0035556; GO:0040008; GO:0045444; GO:0046426 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00017;PF07525; O46581 CHOYP_EF-1A.9.9 m.63040 sp COX41_THEGE 32.374 139 83 4 73 205 10 143 6.31E-18 80.5 COX41_THEGE reviewed "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) (Fragment)" COX4I1 COX4 Theropithecus gelada (Gelada baboon) 144 0 GO:0004129; GO:0005743 0 0 cd00922; PF02936; O75912 CHOYP_BRAFLDRAFT_256433.1.1 m.15728 sp DGKI_HUMAN 59.242 211 80 3 38 243 134 343 6.31E-81 265 DGKI_HUMAN reviewed Diacylglycerol kinase iota (DAG kinase iota) (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) DGKI Homo sapiens (Human) 1065 "excitatory postsynaptic potential [GO:0060079]; habituation [GO:0046959]; intracellular signal transduction [GO:0035556]; neurotransmitter secretion [GO:0007269]; platelet activation [GO:0030168]; positive regulation of Ras protein signal transduction [GO:0046579]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; regulation of long term synaptic depression [GO:1900452]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0004143; GO:0005095; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0007205; GO:0007269; GO:0008021; GO:0030168; GO:0032045; GO:0035556; GO:0043025; GO:0043197; GO:0043234; GO:0043679; GO:0045202; GO:0046579; GO:0046872; GO:0046959; GO:0048471; GO:0048786; GO:0051966; GO:0060076; GO:0060079; GO:0097060; GO:1900452 0 0 0 PF12796;PF00130;PF00609;PF00781; P24861 CHOYP_CCNA.1.1 m.19220 sp CCNA_PATVU 41.379 116 53 8 54 165 58 162 6.31E-07 51.6 CCNA_PATVU reviewed G2/mitotic-specific cyclin-A 0 Patella vulgata (Common limpet) 426 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134;PF16500; P31029 CHOYP_TRIADDRAFT_26208.1.1 m.10460 sp SPYA_CALJA 55.409 379 169 0 43 421 29 407 6.31E-155 447 SPYA_CALJA reviewed "Serine--pyruvate aminotransferase, mitochondrial (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44)" AGXT AGT1 Callithrix jacchus (White-tufted-ear marmoset) 414 "glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; L-alanine catabolic process [GO:0042853]; L-cysteine catabolic process [GO:0019448]; Notch signaling pathway [GO:0007219]; oxalic acid secretion [GO:0046724]; proteasomal protein catabolic process [GO:0010498]" GO:0004760; GO:0005759; GO:0005782; GO:0007219; GO:0008453; GO:0009436; GO:0010498; GO:0016597; GO:0019265; GO:0019448; GO:0030170; GO:0042803; GO:0042853; GO:0043621; GO:0046724 0 0 0 PF00266; P42026 CHOYP_LOC100875987.1.2 m.7720 sp NDUS7_BOVIN 74.054 185 42 1 51 235 38 216 6.31E-99 291 NDUS7_BOVIN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) 216 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005747; GO:0008137; GO:0032981; GO:0046872; GO:0048038; GO:0051539 0 0 0 PF01058; P42026 CHOYP_LOC100875987.2.2 m.63381 sp NDUS7_BOVIN 74.054 185 42 1 51 235 38 216 6.31E-99 291 NDUS7_BOVIN reviewed "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-20kD) (CI-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) (PSST subunit)" NDUFS7 Bos taurus (Bovine) 216 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005747; GO:0008137; GO:0032981; GO:0046872; GO:0048038; GO:0051539 0 0 0 PF01058; P46531 CHOYP_AAEL_AAEL008069.2.2 m.60920 sp NOTC1_HUMAN 32.8 625 331 23 1703 2308 306 860 6.31E-68 261 NOTC1_HUMAN reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 Homo sapiens (Human) 2555 "aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium morphogenesis [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; organ regeneration [GO:0031100]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral transcription [GO:0050434]; prostate gland epithelium morphogenesis [GO:0060740]; pulmonary valve morphogenesis [GO:0003184]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; tissue regeneration [GO:0042246]; transcription initiation from RNA polymerase II promoter [GO:0006367]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0000139; GO:0001047; GO:0001190; GO:0001669; GO:0001701; GO:0001708; GO:0001837; GO:0001889; GO:0001947; GO:0002040; GO:0002052; GO:0002193; GO:0002437; GO:0003157; GO:0003160; GO:0003162; GO:0003169; GO:0003180; GO:0003181; GO:0003184; GO:0003192; GO:0003198; GO:0003203; GO:0003207; GO:0003208; GO:0003209; GO:0003213; GO:0003214; GO:0003219; GO:0003222; GO:0003241; GO:0003256; GO:0003270; GO:0003273; GO:0003344; GO:0003700; GO:0004857; GO:0004872; GO:0005509; GO:0005576; GO:0005634; GO:0005654; GO:0005789; GO:0005829; GO:0005886; GO:0005912; GO:0006355; GO:0006367; GO:0006955; GO:0006959; GO:0007219; GO:0007221; GO:0007283; GO:0007368; GO:0007386; GO:0007409; GO:0007440; GO:0007492; GO:0007507; GO:0008284; GO:0008285; GO:0009912; GO:0009986; GO:0010718; GO:0010812; GO:0010832; GO:0014031; GO:0014807; GO:0016021; GO:0016324; GO:0019899; GO:0021515; GO:0021915; GO:0030216; GO:0030279; GO:0030324; GO:0030335; GO:0030513; GO:0030514; GO:0030900; GO:0031069; GO:0031100; GO:0031490; GO:0031960; GO:0032495; GO:0032496; GO:0035116; GO:0035148; GO:0035914; GO:0035924; GO:0042246; GO:0043065; GO:0043086; GO:0043235; GO:0043565; GO:0045070; GO:0045603; GO:0045608; GO:0045618; GO:0045662; GO:0045668; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0045955; GO:0046427; GO:0046533; GO:0048103; GO:0048708; GO:0048709; GO:0048711; GO:0048715; GO:0048754; GO:0050434; GO:0050679; GO:0050768; GO:0055008; GO:0060038; GO:0060045; GO:0060253; GO:0060271; GO:0060317; GO:0060411; GO:0060412; GO:0060528; GO:0060740; GO:0060768; GO:0060842; GO:0060843; GO:0060948; GO:0060956; GO:0060979; GO:0060982; GO:0061314; GO:0061384; GO:0061419; GO:0070986; GO:0071372; GO:0072017; GO:0072044; GO:0072144; GO:0072602; GO:0090051; GO:0090090; GO:0097150; GO:1901201; GO:1902263; GO:2000737; GO:2000811; GO:2000974; GO:2001027 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P55214 CHOYP_CASP3.3.3 m.53528 sp CASP7_MESAU 29.07 172 82 5 21 188 83 218 6.31E-11 66.2 CASP7_MESAU reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Mesocricetus auratus (Golden hamster) 303 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q24746 CHOYP_LOC100313668.2.6 m.31487 sp NEUR_DROVI 35.897 156 97 3 3 157 98 251 6.31E-25 115 NEUR_DROVI reviewed Protein neuralized neur neu Drosophila virilis (Fruit fly) 747 mesoderm development [GO:0007498]; nervous system development [GO:0007399]; peripheral nervous system development [GO:0007422]; sensory organ development [GO:0007423]; sensory organ precursor cell fate determination [GO:0016360] GO:0003677; GO:0004842; GO:0005634; GO:0005886; GO:0007399; GO:0007422; GO:0007423; GO:0007498; GO:0008270; GO:0016360 0 0 0 PF07177; Q4U2R1 CHOYP_BRAFLDRAFT_120990.17.18 m.61706 sp HERC2_MOUSE 40 70 39 2 309 375 1869 1938 6.31E-08 59.3 HERC2_MOUSE reviewed E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2) Herc2 Jdf2 Kiaa0393 Rjs Mus musculus (Mouse) 4836 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; spermatogenesis [GO:0007283] GO:0004842; GO:0005634; GO:0005737; GO:0005743; GO:0005814; GO:0006281; GO:0006974; GO:0007283; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0031625; GO:0032183; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF11515;PF00173;PF00632;PF06701;PF00415;PF00569; Q59I64 CHOYP_LOC411935.1.1 m.4534 sp YLAT2_DANRE 54.194 465 211 1 25 487 1 465 6.31E-170 490 YLAT2_DANRE reviewed Y+L amino acid transporter 2 (Solute carrier family 7 member 6) (zfSlc7a6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) slc7a6 Danio rerio (Zebrafish) (Brachydanio rerio) 468 0 GO:0005887; GO:0015179; GO:0015297; GO:0016323 0 0 0 PF13520; Q5IS66 CHOYP_DRD2.1.1 m.22336 sp 5HT2C_PANTR 56.41 78 33 1 271 347 299 376 6.31E-22 99.4 5HT2C_PANTR reviewed 5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (Serotonin receptor 2C) HTR2C Pan troglodytes (Chimpanzee) 458 behavioral fear response [GO:0001662]; feeding behavior [GO:0007631]; locomotory behavior [GO:0007626]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [GO:0051482]; regulation of appetite [GO:0032098]; regulation of corticotropin-releasing hormone secretion [GO:0043397]; regulation of neurological system process [GO:0031644] GO:0001587; GO:0001662; GO:0005887; GO:0007208; GO:0007626; GO:0007631; GO:0031644; GO:0032098; GO:0043397; GO:0051482 0 0 0 PF00001; Q61555 CHOYP_LOC100637925.1.4 m.34491 sp FBN2_MOUSE 30.99 1565 803 79 1251 2662 1075 2515 6.31E-116 418 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q63041 CHOYP_A1M.1.2 m.39785 sp A1M_RAT 37.037 135 80 3 233 363 1355 1488 6.31E-14 77.8 A1M_RAT reviewed Alpha-1-macroglobulin (Alpha-1-M) (Alpha-1-macroglobulin 165 kDa subunit) [Cleaved into: Alpha-1-macroglobulin 45 kDa subunit] A1m Pzp Rattus norvegicus (Rat) 1500 embryo implantation [GO:0007566] GO:0004867; GO:0005615; GO:0007566; GO:0032403; GO:0048403; GO:0048406 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q92038 CHOYP_ACOD.6.8 m.49385 sp ACOD_CYPCA 66.977 215 70 1 2 215 109 323 6.31E-102 300 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; Q96MM6 CHOYP_BRAFLDRAFT_208436.13.32 m.43521 sp HS12B_HUMAN 33.167 401 192 13 427 773 38 416 6.31E-52 196 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9UM22 CHOYP_TRIADDRAFT_63666.1.3 m.4525 sp EPDR1_HUMAN 25.628 199 110 9 9 186 30 211 6.31E-07 51.6 EPDR1_HUMAN reviewed Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; E1BZ85 CHOYP_LOC586486.1.1 m.50220 sp MARF1_CHICK 63.871 155 54 1 4 158 341 493 6.32E-63 212 MARF1_CHICK reviewed Meiosis arrest female protein 1 homolog (Limkain-b1) MARF1 LKAP Gallus gallus (Chicken) 1741 meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; regulation of gene expression [GO:0010468] GO:0000166; GO:0003723; GO:0005777; GO:0010468; GO:0048477; GO:0051321 0 0 0 PF11608;PF01936;PF12872; F6QEU4 CHOYP_LIN41.1.3 m.33080 sp LIN41_XENTR 21.339 239 140 8 9 215 141 363 6.32E-08 56.2 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O95613 CHOYP_LOC100368547.20.40 m.23978 sp PCNT_HUMAN 26.746 673 454 14 1400 2060 2443 3088 6.32E-29 131 PCNT_HUMAN reviewed Pericentrin (Kendrin) (Pericentrin-B) PCNT KIAA0402 PCNT2 Homo sapiens (Human) 3336 cilium assembly [GO:0042384]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316] GO:0000086; GO:0000226; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0005874; GO:0007052; GO:0016020; GO:0034451; GO:0042384; GO:0090316 0 0 0 PF10495; P07898 CHOYP_FCER2.9.9 m.30469 sp PGCA_CHICK 36.923 130 70 6 22 146 1895 2017 6.32E-19 85.9 PGCA_CHICK reviewed Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) ACAN AGC1 Gallus gallus (Chicken) 2109 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; P10079 CHOYP_LOC100634060.2.37 m.2551 sp FBP1_STRPU 55.769 260 115 0 1 260 186 445 6.32E-87 282 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P17139 CHOYP_PHUM_PHUM569140.1.1 m.29155 sp CO4A1_CAEEL 36.224 196 114 4 49 240 1335 1523 6.32E-13 71.2 CO4A1_CAEEL reviewed Collagen alpha-1(IV) chain emb-9 clb-2 K04H4.1 Caenorhabditis elegans 1759 embryo development ending in birth or egg hatching [GO:0009792]; extracellular matrix organization [GO:0030198]; muscle organ development [GO:0007517]; nematode larval development [GO:0002119]; positive regulation of protein secretion [GO:0050714] GO:0002119; GO:0005201; GO:0005581; GO:0005604; GO:0007517; GO:0009792; GO:0030198; GO:0050714 0 0 0 PF01413;PF01391; P24014 CHOYP_SLIT2.1.3 m.31887 sp SLIT_DROME 32.323 99 67 0 1 99 629 727 6.32E-12 68.2 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P52947 CHOYP_LOC100371286.1.1 m.49379 sp PDX1_RAT 71.818 110 26 3 128 234 102 209 6.32E-49 167 PDX1_RAT reviewed Pancreas/duodenum homeobox protein 1 (Insulin promoter factor 1) (IPF-1) (Islet/duodenum homeobox 1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) Pdx1 Ipf1 Rattus norvegicus (Rat) 283 "cell differentiation [GO:0030154]; central nervous system development [GO:0007417]; detection of glucose [GO:0051594]; digestive tract development [GO:0048565]; exocrine pancreas development [GO:0031017]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin secretion [GO:0030073]; liver development [GO:0001889]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of cell proliferation [GO:0008285]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nitric oxide mediated signal transduction [GO:0007263]; organ regeneration [GO:0031100]; organ senescence [GO:0010260]; pancreas development [GO:0031016]; positive regulation of cell death [GO:0010942]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA binding [GO:0043388]; positive regulation of insulin secretion [GO:0032024]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; response to alkaloid [GO:0043279]; response to chlorate [GO:0010157]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to fatty acid [GO:0070542]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to iron(II) ion [GO:0010040]; response to leucine [GO:0043201]; response to lipid [GO:0033993]; response to nicotine [GO:0035094]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to vitamin [GO:0033273]; response to wounding [GO:0009611]; smoothened signaling pathway [GO:0007224]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; transdifferentiation [GO:0060290]; type B pancreatic cell differentiation [GO:0003309]" GO:0000122; GO:0000978; GO:0001046; GO:0001889; GO:0003309; GO:0003682; GO:0003700; GO:0005634; GO:0005737; GO:0005829; GO:0006006; GO:0006351; GO:0006355; GO:0006366; GO:0007224; GO:0007263; GO:0007417; GO:0008134; GO:0008284; GO:0008285; GO:0009611; GO:0009749; GO:0010040; GO:0010157; GO:0010260; GO:0010468; GO:0010942; GO:0014070; GO:0016331; GO:0016607; GO:0030073; GO:0030154; GO:0031016; GO:0031017; GO:0031100; GO:0031667; GO:0032024; GO:0032403; GO:0033273; GO:0033993; GO:0034097; GO:0035094; GO:0035774; GO:0042493; GO:0042593; GO:0043201; GO:0043279; GO:0043388; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0048565; GO:0048863; GO:0051384; GO:0051594; GO:0060290; GO:0070542; GO:1902236; GO:2000675 0 0 0 PF00046; Q13231 CHOYP_CHIT1.3.3 m.17004 sp CHIT1_HUMAN 43.249 474 232 8 41 508 23 465 6.32E-126 389 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q26487 CHOYP_EF-1A.5.9 m.37989 sp EF1A_SPOFR 91.139 158 14 0 41 198 41 198 6.32E-103 305 EF1A_SPOFR reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Spodoptera frugiperda (Fall armyworm) 413 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q4R7H5 CHOYP_EF1G.2.3 m.50675 sp EF1G_MACFA 57.358 265 102 3 4 257 1 265 6.32E-104 314 EF1G_MACFA reviewed Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) EEF1G QtsA-15310 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 437 0 GO:0003746 0 0 0 PF00647;PF00043;PF02798; Q4UMH6 CHOYP_ANR52.1.3 m.24460 sp Y381_RICFE 29.504 383 235 8 59 441 784 1131 6.32E-32 138 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q60847 CHOYP_TENN.1.1 m.53900 sp COCA1_MOUSE 21.092 403 280 11 157 551 1731 2103 6.32E-10 66.6 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q6IMK3 CHOYP_BRAFLDRAFT_213951.1.1 m.14919 sp DJC27_DANRE 67.176 262 84 1 6 265 9 270 6.32E-138 392 DJC27_DANRE reviewed DnaJ homolog subfamily C member 27 (Rab and DnaJ domain-containing protein) dnajc27 rbj Danio rerio (Zebrafish) (Brachydanio rerio) 273 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005634; GO:0007264 0 0 cd06257; PF00226;PF00071; Q6IQ20 CHOYP_NAPEP.1.1 m.16542 sp NAPEP_HUMAN 51.36 331 151 5 14 337 61 388 6.32E-122 359 NAPEP_HUMAN reviewed N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) NAPEPLD C7orf18 Homo sapiens (Human) 393 phospholipid catabolic process [GO:0009395]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0005737; GO:0008270; GO:0009395; GO:0042622; GO:0070062; GO:0070290 0 0 0 PF12706; Q80VI1 CHOYP_BRAFLDRAFT_75787.1.5 m.20483 sp TRI56_MOUSE 28.571 126 69 5 18 122 88 213 6.32E-06 48.1 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q9J569 CHOYP_TVAG_287350.2.5 m.13823 sp V162_FOWPN 27.543 403 218 11 55 451 13 347 6.32E-21 100 V162_FOWPN reviewed Putative ankyrin repeat protein FPV162 FPV162 Fowlpox virus (strain NVSL) (FPV) 603 0 0 0 0 0 PF12796;PF09372; B3EWZ6 CHOYP_LOC593967.1.2 m.26281 sp MLRP2_ACRMI 42.069 145 72 6 246 378 1054 1198 6.33E-16 83.6 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D3YXG0 CHOYP_LOC100313665.2.2 m.49938 sp HMCN1_MOUSE 25.59 551 364 24 81 610 4035 4560 6.33E-22 107 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O93233 CHOYP_DGRI_GH19403.1.1 m.18385 sp PLIB_GLOBS 27.273 275 160 11 50 317 88 329 6.33E-10 63.5 PLIB_GLOBS reviewed Phospholipase A2 inhibitor (beta-PLI) 0 Gloydius brevicaudus siniticus (Chinese mamushi) (Agkistrodon blomhoffii siniticus) 331 0 GO:0019834 0 0 0 PF13855; O96064 CHOYP_MYSP.7.9 m.42315 sp MYSP_MYTGA 84.956 226 34 0 1 226 497 722 6.33E-121 366 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P10039 CHOYP_NEMVEDRAFT_V1G228654.1.2 m.597 sp TENA_CHICK 44.706 170 89 4 2 170 1632 1797 6.33E-42 152 TENA_CHICK reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) 1808 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041;PF12661; P18288 CHOYP_RN45S.5.5 m.55875 sp TBAT_ONCMY 98.558 208 3 0 22 229 1 208 6.33E-152 433 TBAT_ONCMY reviewed "Tubulin alpha chain, testis-specific [Cleaved into: Detyrosinated tubulin alpha chain, testis-specific]" 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P35869 CHOYP_LOC100367261.1.1 m.4210 sp AHR_HUMAN 28.169 71 51 0 7 77 322 392 6.33E-07 55.8 AHR_HUMAN reviewed Aryl hydrocarbon receptor (Ah receptor) (AhR) (Class E basic helix-loop-helix protein 76) (bHLHe76) AHR BHLHE76 Homo sapiens (Human) 848 "apoptotic process [GO:0006915]; blood vessel development [GO:0001568]; cell cycle [GO:0007049]; cellular response to glucocorticoid stimulus [GO:0071385]; circadian regulation of gene expression [GO:0032922]; negative regulation of transcription, DNA-templated [GO:0045892]; ovarian follicle development [GO:0001541]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of B cell proliferation [GO:0030888]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to estradiol [GO:0032355]; response to toxic substance [GO:0009636]; response to xenobiotic stimulus [GO:0009410]; transcription from RNA polymerase II promoter [GO:0006366]; xenobiotic metabolic process [GO:0006805]" GO:0001541; GO:0001568; GO:0003677; GO:0003700; GO:0004874; GO:0004879; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006355; GO:0006357; GO:0006366; GO:0006805; GO:0006915; GO:0007049; GO:0008134; GO:0009410; GO:0009636; GO:0010468; GO:0030888; GO:0032355; GO:0032922; GO:0034752; GO:0034753; GO:0035326; GO:0044212; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0046983; GO:0051879; GO:0070888; GO:0071385 0 0 0 PF00010;PF00989;PF08447; Q13148 CHOYP_BRAFLDRAFT_223429.1.2 m.30136 sp TADBP_HUMAN 62.909 275 97 4 36 308 1 272 6.33E-125 371 TADBP_HUMAN reviewed TAR DNA-binding protein 43 (TDP-43) TARDBP TDP43 Homo sapiens (Human) 414 3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear fragmentation involved in apoptotic nuclear change [GO:0030264]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; regulation of cell cycle [GO:0051726]; response to endoplasmic reticulum stress [GO:0034976]; RNA splicing [GO:0008380]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000166; GO:0001205; GO:0001933; GO:0003690; GO:0003700; GO:0003723; GO:0003730; GO:0005634; GO:0005654; GO:0005726; GO:0005737; GO:0006366; GO:0006397; GO:0008380; GO:0010629; GO:0016607; GO:0030264; GO:0032024; GO:0034976; GO:0035061; GO:0042802; GO:0043922; GO:0044822; GO:0051726; GO:0070935; GO:0071765 0 0 0 PF00076; Q2LK54 CHOYP_CLC4K.1.2 m.22040 sp COL12_CHICK 33.065 124 75 3 22 140 602 722 6.33E-16 76.6 COL12_CHICK reviewed Collectin-12 (Collectin-3) (CL-3) (cCL-3) COLEC12 CL3 Gallus gallus (Chicken) 742 0 GO:0005581; GO:0016021; GO:0030246; GO:0046872 0 0 0 PF01391;PF00059; Q5XIA2 CHOYP_BRAFLDRAFT_122687.1.1 m.47713 sp SZRD1_RAT 42.188 128 61 4 4 126 32 151 6.33E-22 87.8 SZRD1_RAT reviewed SUZ domain-containing protein 1 Szrd1 Rattus norvegicus (Rat) 152 0 0 0 0 0 PF12752;PF12901; Q5ZI57 CHOYP_TPPC3.1.1 m.58563 sp TPPC3_CHICK 74.444 180 46 0 1 180 1 180 6.33E-102 293 TPPC3_CHICK reviewed Trafficking protein particle complex subunit 3 TRAPPC3 RCJMB04_30c23 Gallus gallus (Chicken) 180 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0000139; GO:0005783; GO:0005829; GO:0006888; GO:0030008 0 0 cd14942; PF04051; Q61830 CHOYP_LOC100378295.2.4 m.15030 sp MRC1_MOUSE 24.708 514 339 17 28 516 364 854 6.33E-31 132 MRC1_MOUSE reviewed Macrophage mannose receptor 1 (MMR) (CD antigen CD206) Mrc1 Mus musculus (Mouse) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0006898; GO:0009986; GO:0010008; GO:0016021; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; Q69Z37 CHOYP_LOC100367242.2.2 m.54834 sp SAM9L_MOUSE 31.158 613 340 23 16 594 194 758 6.33E-63 229 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q6NWC9 CHOYP_GKAP1.1.1 m.18792 sp GKAP1_DANRE 32.917 240 110 8 4 205 10 236 6.33E-16 79 GKAP1_DANRE reviewed G kinase-anchoring protein 1 gkap1 zgc:85804 Danio rerio (Zebrafish) (Brachydanio rerio) 368 signal transduction [GO:0007165] GO:0005794; GO:0007165 0 0 0 0 Q6UWR7 CHOYP_ENPP6.5.5 m.52931 sp ENPP6_HUMAN 40.295 407 225 7 28 429 21 414 6.33E-99 306 ENPP6_HUMAN reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (E-NPP 6) (NPP-6) (EC 3.1.4.-) (EC 3.1.4.38) (Choline-specific glycerophosphodiester phosphodiesterase) (Glycerophosphocholine cholinephosphodiesterase) (GPC-Cpde) ENPP6 UNQ1889/PRO4334 Homo sapiens (Human) 440 choline metabolic process [GO:0019695]; glycerophospholipid catabolic process [GO:0046475]; lipid metabolic process [GO:0006629] GO:0005576; GO:0005886; GO:0006629; GO:0008081; GO:0008889; GO:0019695; GO:0031225; GO:0046475; GO:0047390; GO:0070062 0 0 0 PF01663; Q7Z3D4 CHOYP_LOC100373008.1.1 m.52998 sp LYSM3_HUMAN 30.769 247 135 7 31 268 20 239 6.33E-30 117 LYSM3_HUMAN reviewed LysM and putative peptidoglycan-binding domain-containing protein 3 LYSMD3 Homo sapiens (Human) 306 0 GO:0016021 0 0 0 PF01476; Q87013 CHOYP_MREP.1.1 m.23653 sp REP6_SCSVF 37.762 143 85 4 32 171 138 279 6.33E-15 75.1 REP6_SCSVF reviewed Para-Rep C6 (Rep6) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.3) (Replication-associated protein of non-essential DNA C6) C6 Subterranean clover stunt virus (strain F) (SCSV) 285 DNA replication [GO:0006260]; protein-DNA covalent cross-linking [GO:0018142] GO:0003677; GO:0003723; GO:0003724; GO:0005524; GO:0006260; GO:0016779; GO:0016888; GO:0018142; GO:0042025; GO:0042624; GO:0046872 0 0 0 PF00910;PF02407; Q8VDL4 CHOYP_LOC100216148.1.1 m.29776 sp ADPGK_MOUSE 33.097 423 269 9 65 481 75 489 6.33E-61 210 ADPGK_MOUSE reviewed ADP-dependent glucokinase (ADP-GK) (ADPGK) (EC 2.7.1.147) Adpgk Mus musculus (Mouse) 496 glycolytic process [GO:0006096] GO:0005576; GO:0005783; GO:0006096; GO:0016020; GO:0043843; GO:0046872 PATHWAY: Carbohydrate degradation; glycolysis. {ECO:0000255|PROSITE-ProRule:PRU00584}. 0 0 PF04587; Q92193 CHOYP_ACT.22.27 m.58203 sp ACT_CRAVI 98.261 115 2 0 1 115 43 157 6.33E-78 233 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96II8 CHOYP_PHUM_PHUM584220.1.1 m.1131 sp LRCH3_HUMAN 35.015 654 339 17 1 613 157 765 6.33E-85 285 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q99M85 CHOYP_LOC100745572.1.1 m.1525 sp SCRT1_MOUSE 65.714 140 48 0 282 421 191 330 6.33E-59 200 SCRT1_MOUSE reviewed Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (mScrt) Scrt1 Mus musculus (Mouse) 348 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of neuron migration [GO:2001222]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005634; GO:0006351; GO:0046872; GO:2001222 0 0 0 PF00096;PF13912; Q9GNE2 CHOYP_PHUM_PHUM465850.2.2 m.57772 sp RL23_AEDAE 89.796 98 10 0 17 114 1 98 6.33E-58 178 RL23_AEDAE reviewed 60S ribosomal protein L23 (AeRpL17A) (L17A) RpL23-A RpL17A AAEL013097; RpL23-B AAEL013583; RpL23-C AAEL015006 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 140 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00238; A4IF63 CHOYP_LOC100374741.8.83 m.8076 sp TRIM2_BOVIN 32.71 107 68 3 37 140 627 732 6.34E-10 59.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8WGA3 CHOYP_LRC4C.1.1 m.63346 sp LFN1L_DANRE 27.075 506 272 21 13 450 1 477 6.34E-32 133 LFN1L_DANRE reviewed Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein lrfn1l zgc:172282 Danio rerio (Zebrafish) (Brachydanio rerio) 687 axonogenesis [GO:0007409] GO:0007409; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF07679;PF13855; O75179 CHOYP_LOC755521.16.28 m.46385 sp ANR17_HUMAN 33.004 506 273 17 6 483 222 689 6.34E-51 194 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P23469 CHOYP_PTPRT.21.45 m.45515 sp PTPRE_HUMAN 31.597 595 353 12 535 1089 115 695 6.34E-80 279 PTPRE_HUMAN reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) PTPRE Homo sapiens (Human) 700 negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005634; GO:0005737; GO:0005886; GO:0006470; GO:0007185; GO:0016021; GO:0033003; GO:0046627 0 0 0 PF00102; Q01622 CHOYP_LOC100160569.1.1 m.15741 sp HLOX2_HELRO 69.291 127 25 3 125 239 160 284 6.34E-48 167 HLOX2_HELRO reviewed Homeobox protein LOX2 (Fragment) LOX2 Helobdella robusta (Californian leech) 429 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; Q24JV9 CHOYP_LOC100632389.1.1 m.36983 sp L3BPA_DANRE 50.943 106 51 1 742 846 27 132 6.34E-29 126 L3BPA_DANRE reviewed Galectin-3-binding protein A (Lectin galactoside-binding soluble 3-binding protein A) lgals3bpa lgals3bp zgc:136780 Danio rerio (Zebrafish) (Brachydanio rerio) 567 cell adhesion [GO:0007155] GO:0005044; GO:0005578; GO:0007155; GO:0016020 0 0 0 PF07707;PF00651;PF00530; Q2YGT9 CHOYP_BRAFLDRAFT_114734.8.8 m.66848 sp RL6_PIG 60.215 93 34 1 429 521 195 284 6.34E-26 110 RL6_PIG reviewed 60S ribosomal protein L6 RPL6 Sus scrofa (Pig) 284 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; Q39575 CHOYP_LOC100374716.1.1 m.919 sp DYHG_CHLRE 31.356 118 74 4 1 116 4324 4436 6.34E-12 65.1 DYHG_CHLRE reviewed "Dynein gamma chain, flagellar outer arm" ODA2 ODA-2 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4485 cilium movement involved in cell motility [GO:0060294]; outer dynein arm assembly [GO:0036158] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0016887; GO:0030286; GO:0031514; GO:0036158; GO:0060294 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q503Y4 CHOYP_BRAFLDRAFT_126058.1.1 m.1201 sp OVCA2_DANRE 52.232 224 93 4 2 214 6 226 6.34E-74 226 OVCA2_DANRE reviewed Esterase OVCA2 (EC 3.1.2.-) (Ovarian cancer-associated gene 2 protein homolog) ovca2 zgc:110011 Danio rerio (Zebrafish) (Brachydanio rerio) 227 0 GO:0016787 0 0 0 PF03959; Q5DU57 CHOYP_ISCW_ISCW011606.1.2 m.39943 sp SPT13_MOUSE 46.032 567 277 9 570 1126 73 620 6.34E-166 508 SPT13_MOUSE reviewed Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2) Spata13 Mus musculus (Mouse) 656 cell migration [GO:0016477]; filopodium assembly [GO:0046847]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]; regulation of Rho protein signal transduction [GO:0035023] GO:0005085; GO:0005654; GO:0005737; GO:0016477; GO:0030027; GO:0030032; GO:0030175; GO:0030334; GO:0030676; GO:0032587; GO:0035023; GO:0035556; GO:0046847 0 0 0 PF00169;PF00621;PF00018; Q6DC53 CHOYP_LOC585726.1.1 m.50723 sp CTU2_DANRE 48.864 88 41 2 15 98 1 88 6.34E-17 77.8 CTU2_DANRE reviewed Cytoplasmic tRNA 2-thiolation protein 2 ctu2 ncs2 zgc:101113 Danio rerio (Zebrafish) (Brachydanio rerio) 501 protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] GO:0000049; GO:0002098; GO:0005829; GO:0016779; GO:0032447; GO:0034227 PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03054}. 0 0 PF10288; Q6PG29 CHOYP_SKAP2.1.1 m.63022 sp SKAP2_DANRE 31.323 431 204 11 1 429 1 341 6.34E-48 170 SKAP2_DANRE reviewed Src kinase-associated phosphoprotein 2 (Src family-associated phosphoprotein 2) skap2 scap2 zgc:65975 Danio rerio (Zebrafish) (Brachydanio rerio) 341 B cell activation [GO:0042113]; immune response-activating signal transduction [GO:0002757] GO:0002757; GO:0005070; GO:0005737; GO:0005886; GO:0042113 0 0 0 PF00169;PF00018; Q9HB19 CHOYP_PLEKHA1.2.2 m.21816 sp PKHA2_HUMAN 43.144 299 140 7 66 336 1 297 6.34E-68 224 PKHA2_HUMAN reviewed Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) PLEKHA2 TAPP2 Homo sapiens (Human) 425 positive regulation of cell-matrix adhesion [GO:0001954] GO:0001954; GO:0001968; GO:0005634; GO:0005737; GO:0005886; GO:0016020; GO:0030165; GO:0035091; GO:0043234; GO:0043236 0 0 0 PF00169; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G199235.6.15 m.33122 sp SACS_HUMAN 22.166 591 377 21 13 551 399 958 6.34E-19 95.1 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9V4M2 CHOYP_BRAFLDRAFT_85511.9.23 m.32657 sp WECH_DROME 28.037 107 72 1 88 189 564 670 6.34E-07 52.4 WECH_DROME reviewed Protein wech (Protein dappled) wech dpld CG42396 Drosophila melanogaster (Fruit fly) 832 cell differentiation [GO:0030154]; instar larval development [GO:0002168]; muscle attachment [GO:0016203]; regulation of cell-cell adhesion mediated by integrin [GO:0033632] GO:0002168; GO:0005622; GO:0005927; GO:0008270; GO:0016203; GO:0030154; GO:0030674; GO:0033632 0 0 0 PF01436;PF00643; A8TX70 CHOYP_LOC100633626.1.1 m.54506 sp CO6A5_HUMAN 37.097 186 111 4 19 202 626 807 6.35E-25 114 CO6A5_HUMAN reviewed Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) 2615 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; F6WXT2 CHOYP_NU188.1.2 m.15113 sp NU188_XENTR 34.901 404 255 6 12 411 5 404 6.35E-70 243 NU188_XENTR reviewed Nucleoporin NUP188 homolog nup188 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1739 mRNA transport [GO:0051028]; protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405] GO:0006405; GO:0006606; GO:0017056; GO:0044611; GO:0051028 0 0 0 PF10487; O75382 CHOYP_contig_045769 m.53364 sp TRIM3_HUMAN 26.047 215 137 10 219 420 484 689 6.35E-06 52.4 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P22105 CHOYP_MEGF11.3.11 m.34077 sp TENX_HUMAN 26.511 513 239 33 3 400 207 696 6.35E-26 117 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P60868 CHOYP_LOC581452.3.4 m.41001 sp RS20_RAT 84.821 112 15 1 5 114 1 112 6.35E-62 189 RS20_RAT reviewed 40S ribosomal protein S20 Rps20 Rattus norvegicus (Rat) 119 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00338; Q3UTY6 CHOYP_THSD4.2.2 m.57001 sp THSD4_MOUSE 33.031 772 448 17 76 833 290 1006 6.35E-136 432 THSD4_MOUSE reviewed Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) (ADAMTS-like protein 4) (ADAMTSL-4) Thsd4 Mus musculus (Mouse) 1018 elastic fiber assembly [GO:0048251] GO:0001527; GO:0004222; GO:0005578; GO:0048251; GO:0070062 0 0 0 PF05986;PF08686;PF00090; Q5F4C0 CHOYP_BRAFLDRAFT_78412.1.1 m.30518 sp HVCN1_CHICK 40.816 98 50 3 223 317 90 182 6.35E-13 71.6 HVCN1_CHICK reviewed Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) HVCN1 RCJMB04_1c7 Gallus gallus (Chicken) 235 cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transport [GO:0015992]; response to pH [GO:0009268]; response to zinc ion [GO:0010043] GO:0005887; GO:0009268; GO:0010043; GO:0015992; GO:0016021; GO:0030171; GO:0071294; GO:0071467 0 0 0 PF00520;PF16799; Q5UBV8 CHOYP_TNFSF14.1.1 m.33768 sp TNF15_MOUSE 27.607 163 106 5 105 260 95 252 6.35E-07 52.8 TNF15_MOUSE reviewed Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) Tnfsf15 Tl1 Vegi Mus musculus (Mouse) 252 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cytokine metabolic process [GO:0042107]; immune response [GO:0006955] GO:0005615; GO:0005622; GO:0005886; GO:0006919; GO:0006955; GO:0007250; GO:0016021; GO:0042107 0 0 0 PF00229; Q60431 CHOYP_CASP7.18.23 m.52787 sp CASP3_MESAU 33.766 154 79 4 45 198 34 164 6.35E-14 75.5 CASP3_MESAU reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q7PCJ9 CHOYP_BRAFLDRAFT_285620.4.6 m.41181 sp SAT2_PIG 32.164 171 103 4 18 178 1 168 6.35E-24 95.1 SAT2_PIG reviewed Diamine acetyltransferase 2 (EC 2.3.1.57) (Polyamine N-acetyltransferase 2) (Spermidine/spermine N(1)-acetyltransferase 2) SAT2 SSAT2 Sus scrofa (Pig) 170 putrescine catabolic process [GO:0009447] GO:0004145; GO:0005737; GO:0009447 PATHWAY: Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. 0 0 PF00583; Q8K078 CHOYP_SLCO4A1.1.4 m.10763 sp SO4A1_MOUSE 37.576 495 298 5 6 494 228 717 6.35E-115 358 SO4A1_MOUSE reviewed Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Mus musculus (Mouse) 723 organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327] GO:0005887; GO:0008514; GO:0015347; GO:0015349; GO:0015711; GO:0042403; GO:0043252; GO:0070327 0 0 cd06174; PF07648;PF03137; Q9ESN6 CHOYP_BRAFLDRAFT_255103.18.18 m.65488 sp TRIM2_MOUSE 25.309 162 114 4 184 340 547 706 6.35E-07 55.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NZJ4 CHOYP_NEMVEDRAFT_V1G247395.4.8 m.26821 sp SACS_HUMAN 28.846 988 595 28 30 973 2359 3282 6.35E-99 348 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9VXV9 CHOYP_WCSD.1.1 m.3611 sp WCSD_DROME 52.174 138 63 2 42 177 72 208 6.35E-38 135 WCSD_DROME reviewed WSCD family member CG9164 CG9164 Drosophila melanogaster (Fruit fly) 317 0 GO:0016021 0 0 0 0 Q9Y6H5 CHOYP_LOC582832.1.1 m.36307 sp SNCAP_HUMAN 26.19 168 111 4 341 503 391 550 6.35E-09 63.9 SNCAP_HUMAN reviewed Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein) SNCAIP Homo sapiens (Human) 919 cell death [GO:0008219]; cellular protein metabolic process [GO:0044267]; dopamine metabolic process [GO:0042417]; regulation of inclusion body assembly [GO:0090083]; regulation of neurotransmitter secretion [GO:0046928] GO:0005737; GO:0005829; GO:0008021; GO:0008219; GO:0031625; GO:0042417; GO:0042734; GO:0042802; GO:0043025; GO:0044267; GO:0046928; GO:0090083 0 0 0 PF12796;PF16700; Q9Z223 CHOYP_TRIADDRAFT_23075.1.1 m.48886 sp MOC2B_MOUSE 59.859 142 57 0 2 143 45 186 6.35E-62 191 MOC2B_MOUSE reviewed Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) Mocs2 Mus musculus (Mouse) 189 molybdopterin cofactor biosynthetic process [GO:0032324]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0005634; GO:0005737; GO:0005829; GO:0006777; GO:0019008; GO:0030366; GO:0032324; GO:0042802 PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03052}. 0 cd00756; PF02391; P04233 CHOYP_LOC100371332.2.6 m.27514 sp HG2A_HUMAN 51.02 49 24 0 9 57 228 276 6.36E-09 60.1 HG2A_HUMAN reviewed HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74) CD74 DHLAG Homo sapiens (Human) 296 "activation of MAPK activity [GO:0000187]; antigen processing and presentation of endogenous antigen [GO:0019883]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cell proliferation [GO:0008283]; chaperone mediated protein folding requiring cofactor [GO:0051085]; defense response [GO:0006952]; immunoglobulin mediated immune response [GO:0016064]; intracellular protein transport [GO:0006886]; leukocyte migration [GO:0050900]; macrophage migration inhibitory factor signaling pathway [GO:0035691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of peptide secretion [GO:0002792]; negative regulation of T cell differentiation [GO:0045581]; negative thymic T cell selection [GO:0045060]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of dendritic cell antigen processing and presentation [GO:0002606]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of type 2 immune response [GO:0002830]; positive thymic T cell selection [GO:0045059]; prostaglandin biosynthetic process [GO:0001516]; protein complex assembly [GO:0006461]; regulation of macrophage activation [GO:0043030]; signal transduction [GO:0007165]; T cell selection [GO:0045058]" GO:0000139; GO:0000187; GO:0001516; GO:0001540; GO:0001961; GO:0002606; GO:0002792; GO:0002830; GO:0002906; GO:0004896; GO:0005622; GO:0005765; GO:0005771; GO:0005773; GO:0005886; GO:0006461; GO:0006886; GO:0006952; GO:0007165; GO:0008283; GO:0009897; GO:0009986; GO:0012507; GO:0016020; GO:0016021; GO:0016064; GO:0019883; GO:0019886; GO:0019955; GO:0023026; GO:0030658; GO:0030666; GO:0030669; GO:0030890; GO:0032588; GO:0035691; GO:0035692; GO:0035693; GO:0035718; GO:0042289; GO:0042613; GO:0042658; GO:0042802; GO:0043030; GO:0043066; GO:0043202; GO:0043518; GO:0044183; GO:0045058; GO:0045059; GO:0045060; GO:0045581; GO:0045582; GO:0048146; GO:0050731; GO:0050900; GO:0051085; GO:0060907; GO:0070062; GO:0070374; GO:0071556; GO:0090023; GO:1902166; GO:2000343 0 0 0 PF09307;PF08831;PF00086; P18700 CHOYP_LOC373275.2.7 m.14497 sp TBB_STRPU 97.79 181 3 1 1 180 111 291 6.36E-131 371 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P29176 CHOYP_LOC100373869.1.1 m.64294 sp FOSX_MSVFR 48 75 39 0 197 271 106 180 6.36E-16 78.6 FOSX_MSVFR reviewed Transforming protein v-Fos/v-Fox FOS-FOX FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus) 244 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0003700; GO:0006357; GO:0042025; GO:0043565 0 0 0 PF00170; P53013 CHOYP_EF-1A.5.9 m.37988 sp EF1A_CAEEL 81.517 211 39 0 15 225 224 434 6.36E-126 367 EF1A_CAEEL reviewed Elongation factor 1-alpha (EF-1-alpha) eft-3 F31E3.5; eft-4 R03G5.1 Caenorhabditis elegans 463 embryo development ending in birth or egg hatching [GO:0009792]; growth [GO:0040007] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0008135; GO:0009792; GO:0040007 0 0 0 PF03144;PF03143; P78318 CHOYP_IGBP1.1.1 m.4984 sp IGBP1_HUMAN 34.188 117 75 1 8 124 11 125 6.36E-17 79.3 IGBP1_HUMAN reviewed Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16) IGBP1 IBP1 Homo sapiens (Human) 339 B cell activation [GO:0042113]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of protein dephosphorylation [GO:0035308]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of microtubule-based movement [GO:0060632]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165] GO:0000122; GO:0005737; GO:0005829; GO:0005874; GO:0007165; GO:0008601; GO:0032873; GO:0034612; GO:0035306; GO:0035308; GO:0042113; GO:0043154; GO:0045944; GO:0051721; GO:0060632; GO:0070555; GO:2001234 0 0 0 PF04177; Q24307 CHOYP_XIAP.5.7 m.46806 sp DIAP2_DROME 35.172 145 80 4 24 154 352 496 6.36E-22 94 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q66J69 CHOYP_BRAFLDRAFT_122927.1.1 m.51870 sp RNG2A_XENLA 61.538 338 107 5 6 320 5 342 6.36E-139 400 RNG2A_XENLA reviewed E3 ubiquitin-protein ligase RING2-A (EC 6.3.2.-) (RING finger protein 1B-A) (RING1b-A) (RING finger protein 2-A) rnf2-a ring1b-a Xenopus laevis (African clawed frog) 344 "histone H2A-K119 monoubiquitination [GO:0036353]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0006351; GO:0008270; GO:0016874; GO:0031519; GO:0035102; GO:0036353; GO:0071339 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF16207; Q7Z5P9 CHOYP_HKNMT.1.1 m.47124 sp MUC19_HUMAN 34.755 1102 510 62 1 960 3798 4832 6.36E-14 80.5 MUC19_HUMAN reviewed Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) 8384 O-glycan processing [GO:0016266] GO:0005796; GO:0016266; GO:0070062 0 0 0 PF08742;PF01826;PF00094; Q7ZV80 CHOYP_LOC100373830.1.1 m.25323 sp SPF30_DANRE 50 150 65 4 6 153 4 145 6.36E-42 142 SPF30_DANRE reviewed Survival of motor neuron-related-splicing factor 30 (Survival motor neuron domain-containing protein 1) smndc1 spf30 Danio rerio (Zebrafish) (Brachydanio rerio) 237 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0003723; GO:0005681; GO:0005737; GO:0006397; GO:0008380; GO:0015030; GO:0016607 0 0 0 PF06003; Q86WI1 CHOYP_PKHD1L1.1.5 m.9942 sp PKHL1_HUMAN 33.513 1116 671 28 159 1228 18 1108 6.36E-165 549 PKHL1_HUMAN reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) PKHD1L1 Homo sapiens (Human) 4243 immune response [GO:0006955] GO:0004872; GO:0005615; GO:0005829; GO:0006955; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8C033 CHOYP_PHUM_PHUM169900.1.2 m.49859 sp ARHGA_MOUSE 31.824 839 504 21 294 1087 378 1193 6.36E-121 412 ARHGA_MOUSE reviewed Rho guanine nucleotide exchange factor 10 Arhgef10 Kiaa0294 Mus musculus (Mouse) 1345 activation of GTPase activity [GO:0090630]; centrosome duplication [GO:0051298]; mitotic spindle assembly [GO:0090307]; myelination in peripheral nervous system [GO:0022011]; positive regulation of stress fiber assembly [GO:0051496]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005813; GO:0005829; GO:0019894; GO:0022011; GO:0035023; GO:0051298; GO:0051496; GO:0090307; GO:0090630 0 0 0 PF00621; Q8K3I9 CHOYP_LOC100373230.1.1 m.57154 sp GLCI1_MOUSE 36.927 371 163 21 61 412 138 456 6.36E-37 144 GLCI1_MOUSE reviewed Glucocorticoid-induced transcript 1 protein (Glucocorticoid-induced gene 18 protein) (Testhymin) (Thymocyte/spermatocyte selection protein 1) Glcci1 Gig18 Tssn1 Mus musculus (Mouse) 537 0 GO:0005737 0 0 0 PF15388; Q96GP6 CHOYP_SREC2.8.9 m.47518 sp SREC2_HUMAN 39.267 191 101 7 22 208 236 415 6.36E-27 110 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9R1R2 CHOYP_LOC100374741.27.83 m.24541 sp TRIM3_MOUSE 26.812 276 171 14 298 557 482 742 6.36E-11 68.9 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A2VDD2 CHOYP_BRAFLDRAFT_126378.1.2 m.10175 sp TC1DB_XENLA 36.97 165 104 0 51 215 12 176 6.37E-30 112 TC1DB_XENLA reviewed Tctex1 domain-containing protein 1-B (Fragment) tctex1d1-b Xenopus laevis (African clawed frog) 176 0 0 0 0 0 PF03645; O88846 CHOYP_RNF4.1.1 m.44155 sp RNF4_RAT 33.493 209 110 8 26 226 7 194 6.37E-19 84.3 RNF4_RAT reviewed E3 ubiquitin-protein ligase RNF4 (EC 6.3.2.-) (RING finger protein 4) (Small nuclear ring finger protein) (Protein SNURF) Rnf4 Snurf Rattus norvegicus (Rat) 194 "cellular response to arsenic-containing substance [GO:0071243]; cellular response to cytokine stimulus [GO:0071345]; cellular response to gamma radiation [GO:0071480]; cellular response to hydroxyurea [GO:0072711]; cellular response to testosterone stimulus [GO:0071394]; male gonad development [GO:0008584]; negative regulation of cell death [GO:0060548]; negative regulation of protein sumoylation [GO:0033234]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]; response to arsenic-containing substance [GO:0046685]; response to estradiol [GO:0032355]; response to human chorionic gonadotropin [GO:0044752]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006351; GO:0007283; GO:0008270; GO:0008584; GO:0016567; GO:0016605; GO:0016874; GO:0017025; GO:0030331; GO:0031491; GO:0031624; GO:0032184; GO:0032355; GO:0033142; GO:0033234; GO:0033768; GO:0042803; GO:0043161; GO:0044752; GO:0045893; GO:0045944; GO:0046685; GO:0050681; GO:0051865; GO:0060548; GO:0061630; GO:0070534; GO:0070936; GO:0070979; GO:0071243; GO:0071345; GO:0071394; GO:0071480; GO:0072711; GO:0085020; GO:0090169; GO:0090234 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; O95947 CHOYP_TBX20.1.4 m.9929 sp TBX6_HUMAN 43.721 215 116 2 190 399 90 304 6.37E-52 185 TBX6_HUMAN reviewed T-box transcription factor TBX6 (T-box protein 6) TBX6 Homo sapiens (Human) 436 "anatomical structure morphogenesis [GO:0009653]; cell fate specification [GO:0001708]; mesoderm development [GO:0007498]; mesoderm formation [GO:0001707]; negative regulation of neuron maturation [GO:0014043]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; signal transduction involved in regulation of gene expression [GO:0023019]; somite rostral/caudal axis specification [GO:0032525]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001085; GO:0001102; GO:0001191; GO:0001707; GO:0001708; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007498; GO:0009653; GO:0010977; GO:0014043; GO:0023019; GO:0032525; GO:0045944 0 0 0 PF00907; P17955 CHOYP_NUP62L.1.1 m.15606 sp NUP62_RAT 57.848 223 89 1 294 516 308 525 6.37E-87 280 NUP62_RAT reviewed Nuclear pore glycoprotein p62 (62 kDa nucleoporin) (Nucleoporin Nup62) Nup62 Rattus norvegicus (Rat) 525 "cell aging [GO:0007569]; cell death [GO:0008219]; cell surface receptor signaling pathway [GO:0007166]; mitotic nuclear division [GO:0007067]; mRNA transport [GO:0051028]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of programmed cell death [GO:0043069]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of transcription, DNA-templated [GO:0045893]; protein heterotrimerization [GO:0070208]; protein import into nucleus [GO:0006606]; regulation of protein import into nucleus [GO:0042306]; ribonucleoprotein complex export from nucleus [GO:0071426]; RNA export from nucleus [GO:0006405]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000922; GO:0005487; GO:0005543; GO:0005642; GO:0005643; GO:0005737; GO:0006351; GO:0006405; GO:0006606; GO:0007067; GO:0007166; GO:0007283; GO:0007569; GO:0008219; GO:0008285; GO:0017056; GO:0019894; GO:0030159; GO:0030529; GO:0031965; GO:0042059; GO:0042169; GO:0042306; GO:0043066; GO:0043069; GO:0043123; GO:0043130; GO:0043234; GO:0043407; GO:0044613; GO:0045893; GO:0046580; GO:0046966; GO:0051028; GO:0070208; GO:0071426; GO:0090543 0 0 0 PF05064; P28827 CHOYP_PTPRM.12.15 m.52060 sp PTPRM_HUMAN 29.766 598 369 17 277 839 818 1399 6.37E-66 243 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; Q5M9B1 CHOYP_BRAFLDRAFT_118668.1.3 m.11225 sp SPSB3_XENLA 43.269 104 56 1 10 113 105 205 6.37E-24 96.7 SPSB3_XENLA reviewed SPRY domain-containing SOCS box protein 3 (SSB-3) spsb3 Xenopus laevis (African clawed frog) 360 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07525;PF00622; Q5RJ80 CHOYP_LOC100701854.5.6 m.32021 sp CAPR2_DANRE 33.835 133 79 5 87 215 784 911 6.37E-11 64.7 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5U2P1 CHOYP_CNNM2.1.1 m.61572 sp CNNM2_RAT 62.745 357 130 2 138 493 236 590 6.37E-160 478 CNNM2_RAT reviewed Metal transporter CNNM2 (Ancient conserved domain-containing protein 2) (Cyclin-M2) Cnnm2 Acdp2 Rattus norvegicus (Rat) 875 magnesium ion homeostasis [GO:0010960]; magnesium ion transport [GO:0015693] GO:0010960; GO:0015693; GO:0016021; GO:0016323 0 0 0 PF00571;PF01595; Q6R5N8 CHOYP_BRAFLDRAFT_87577.2.2 m.45545 sp TLR13_MOUSE 29.323 133 84 5 86 210 834 964 6.37E-06 50.8 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q86Y13 CHOYP_NEMVEDRAFT_V1G224392.1.3 m.31703 sp DZIP3_HUMAN 29.07 86 61 0 64 149 455 540 6.37E-06 53.1 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8TCB0 CHOYP_BRAFLDRAFT_91636.10.11 m.61352 sp IFI44_HUMAN 28.042 378 246 9 45 421 24 376 6.37E-33 132 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q9UA35 CHOYP_S28A2.1.1 m.36830 sp S28A3_EPTST 41.228 342 195 3 48 389 78 413 6.37E-82 267 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; Q9W7R4 CHOYP_LOC100369767.3.4 m.54779 sp TEN3_DANRE 34.259 108 49 6 63 170 548 633 6.37E-06 54.3 TEN3_DANRE reviewed Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) tenm3 odz3 tnm3 Danio rerio (Zebrafish) (Brachydanio rerio) 2590 dendrite guidance [GO:0070983]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of neuron projection development [GO:0010976]; retinal ganglion cell axon guidance [GO:0031290]; self proteolysis [GO:0097264]; signal transduction [GO:0007165] GO:0007156; GO:0007165; GO:0010976; GO:0016020; GO:0016021; GO:0030424; GO:0031290; GO:0042803; GO:0046982; GO:0070983; GO:0097264 0 0 0 PF06484;PF15636; Q9WVC1 CHOYP_SLIT1.2.5 m.17441 sp SLIT2_RAT 34.252 254 141 5 26 278 497 725 6.37E-35 138 SLIT2_RAT reviewed Slit homolog 2 protein (Slit-2) (Fragment) Slit2 Rattus norvegicus (Rat) 766 axon extension involved in axon guidance [GO:0048846]; brain development [GO:0007420]; central nervous system projection neuron axonogenesis [GO:0021952]; negative regulation of cell growth [GO:0030308]; negative regulation of inflammatory response [GO:0050728]; negative regulation of monocyte chemotaxis [GO:0090027]; regulation of axonogenesis [GO:0050770]; response to nutrient levels [GO:0031667]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510] GO:0004963; GO:0005578; GO:0005615; GO:0005886; GO:0007420; GO:0008201; GO:0016021; GO:0021510; GO:0021952; GO:0030308; GO:0031290; GO:0031667; GO:0035385; GO:0043395; GO:0048495; GO:0048846; GO:0050728; GO:0050770; GO:0090027 0 0 0 PF13855;PF01463;PF01462; O35449 CHOYP_LOC100378921.1.2 m.49482 sp PRRT1_MOUSE 34.118 85 56 0 52 136 219 303 6.38E-09 55.8 PRRT1_MOUSE reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) Prrt1 Ng5 SynDIG4 Mus musculus (Mouse) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; P04323 CHOYP_LOC579970.1.5 m.4690 sp POL3_DROME 43.655 197 106 2 1 196 431 623 6.38E-42 167 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P0C754 CHOYP_SYCP2.2.2 m.47727 sp VF71_ASFK5 31.724 145 81 3 471 615 49 175 6.38E-09 59.3 VF71_ASFK5 reviewed Protein DP71L Ken-167 African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV) 185 modulation by virus of host PP1 activity [GO:0039586]; suppression by virus of host type I interferon-mediated signaling pathway [GO:0039502] GO:0039502; GO:0039586 0 0 0 PF10488; Q3SZ76 CHOYP_ISCW_ISCW008596.2.2 m.44077 sp COMD3_BOVIN 39.691 194 117 0 1 194 1 194 6.38E-47 155 COMD3_BOVIN reviewed COMM domain-containing protein 3 COMMD3 Bos taurus (Bovine) 195 "regulation of transcription, DNA-templated [GO:0006355]; sodium ion transport [GO:0006814]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006814 0 0 0 PF07258; Q4FZG9 CHOYP_LOC581594.3.3 m.40960 sp NUA4L_MOUSE 39.13 69 42 0 49 117 11 79 6.38E-12 60.5 NUA4L_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 Ndufa4l2 Mus musculus (Mouse) 87 hydrogen ion transmembrane transport [GO:1902600] GO:0005751; GO:0008137; GO:1902600 0 0 0 PF06522; Q4R8T1 CHOYP_BRAFLDRAFT_117976.1.3 m.22767 sp EFCB6_MACFA 19.423 659 397 14 337 995 7 531 6.38E-16 86.3 EFCB6_MACFA reviewed EF-hand calcium-binding domain-containing protein 6 (DJ-1-binding protein) (DJBP) (Fragment) EFCAB6 DJBP QtsA-11542 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 646 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q5E9W3 CHOYP_PYRD.1.1 m.47593 sp PYRD_BOVIN 58.247 388 152 5 13 393 8 392 6.38E-151 435 PYRD_BOVIN reviewed "Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)" DHODH Bos taurus (Bovine) 395 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205] GO:0004152; GO:0005737; GO:0005743; GO:0006207; GO:0016021; GO:0044205 PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. 0 cd04738; PF01180; Q6B9X6 CHOYP_LOC100372473.3.5 m.39839 sp VWKA_DICDI 28.814 177 114 5 5 180 121 286 6.38E-12 71.6 VWKA_DICDI reviewed Alpha-protein kinase vwkA (EC 2.7.11.1) (von Willebrand factor A alpha-kinase) (vWF kinase) vwkA DDB_G0268144 Dictyostelium discoideum (Slime mold) 625 contractile vacuole discharge [GO:0070177]; contractile vacuole organization [GO:0033298]; hypotonic response [GO:0006971]; mitotic cytokinesis [GO:0000281]; myosin II filament organization [GO:0031038]; peptidyl-serine modification [GO:0018209]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; regulation of sorocarp development [GO:0031156]; sorocarp morphogenesis [GO:0031288] GO:0000281; GO:0000331; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006971; GO:0018107; GO:0018209; GO:0031038; GO:0031156; GO:0031164; GO:0031288; GO:0033298; GO:0048471; GO:0070177 0 0 0 PF02816; Q7Z5P9 CHOYP_contig_030053 m.34143 sp MUC19_HUMAN 36 125 77 1 9 133 2241 2362 6.38E-06 47.8 MUC19_HUMAN reviewed Mucin-19 (MUC-19) MUC19 Homo sapiens (Human) 8384 O-glycan processing [GO:0016266] GO:0005796; GO:0016266; GO:0070062 0 0 0 PF08742;PF01826;PF00094; Q86DA5 CHOYP_LOC100370582.1.1 m.7903 sp SARM1_CAEEL 42.188 64 35 2 253 316 614 675 6.38E-06 53.5 SARM1_CAEEL reviewed Sterile alpha and TIR motif-containing protein tir-1 (Neuronal symmetry protein 2) (SARM1 homolog) tir-1 nsy-2 F13B10.1 Caenorhabditis elegans 1000 activation of MAPK activity [GO:0000187]; cell-cell signaling involved in cell fate commitment [GO:0045168]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; determination of adult lifespan [GO:0008340]; innate immune response [GO:0045087]; nervous system development [GO:0007399]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium [GO:1902097]; protein localization [GO:0008104]; signal transduction [GO:0007165] GO:0000187; GO:0007165; GO:0007399; GO:0008104; GO:0008340; GO:0017137; GO:0019901; GO:0035591; GO:0042742; GO:0042802; GO:0045087; GO:0045168; GO:0045944; GO:0050832; GO:1902097; GO:1904115 0 0 0 PF00536;PF07647;PF13676; Q8K2J9 CHOYP_BTBD6.4.6 m.25255 sp BTBD6_MOUSE 20.739 352 226 8 11 360 186 486 6.38E-16 82.4 BTBD6_MOUSE reviewed BTB/POZ domain-containing protein 6 Btbd6 Mus musculus (Mouse) 488 0 GO:0000932 0 0 0 PF07707;PF00651;PF08005; Q99417 CHOYP_BRAFLDRAFT_115113.1.2 m.31023 sp MYCBP_HUMAN 65.957 94 32 0 45 138 1 94 6.38E-40 132 MYCBP_HUMAN reviewed C-Myc-binding protein (Associate of Myc 1) (AMY-1) MYCBP AMY1 Homo sapiens (Human) 103 "regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003713; GO:0005634; GO:0005737; GO:0005739; GO:0006351; GO:0006355; GO:0007283 0 0 0 0 Q9EQC4 CHOYP_LOC588095.1.1 m.25041 sp ELOV4_MOUSE 47.368 285 136 2 15 286 29 312 6.38E-90 273 ELOV4_MOUSE reviewed Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) Elovl4 Mus musculus (Mouse) 312 "fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" GO:0005783; GO:0005789; GO:0006636; GO:0009922; GO:0019367; GO:0030176; GO:0034626; GO:0035338; GO:0042761; GO:0102336; GO:0102337; GO:0102338 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03204}. 0 0 PF01151; Q9ESN6 CHOYP_TRIM2.42.59 m.43682 sp TRIM2_MOUSE 20.796 226 169 4 293 512 486 707 6.38E-10 65.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JI19 CHOYP_FIBP.1.1 m.36402 sp FIBP_MOUSE 53.463 361 160 4 2 361 3 356 6.38E-133 386 FIBP_MOUSE reviewed Acidic fibroblast growth factor intracellular-binding protein (aFGF intracellular-binding protein) (FGF-1 intracellular-binding protein) Fibp Mus musculus (Mouse) 357 platelet aggregation [GO:0070527] GO:0005634; GO:0012505; GO:0016020; GO:0017134; GO:0070062; GO:0070527 0 0 0 PF05427; Q9UER7 CHOYP_LOC100368330.1.2 m.16204 sp DAXX_HUMAN 38.222 225 130 4 658 876 164 385 6.38E-41 166 DAXX_HUMAN reviewed Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein) DAXX BING2 DAP6 Homo sapiens (Human) 740 "activation of JUN kinase activity [GO:0007257]; androgen receptor signaling pathway [GO:0030521]; apoptotic process [GO:0006915]; cellular response to anoxia [GO:0071454]; cellular response to tumor necrosis factor [GO:0071356]; chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome assembly [GO:0006334]; PML body organization [GO:0030578]; positive regulation of apoptotic process [GO:0043065]; positive regulation of histone phosphorylation [GO:0033129]; positive regulation of neuron death [GO:1901216]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; regulation of protein ubiquitination [GO:0031396]; regulation of transcription, DNA-templated [GO:0006355]; response to metal ion [GO:0010038]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]" GO:0000122; GO:0000775; GO:0001741; GO:0001934; GO:0002039; GO:0003714; GO:0005057; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0005874; GO:0005938; GO:0006334; GO:0006338; GO:0006351; GO:0006355; GO:0006915; GO:0007257; GO:0008134; GO:0008625; GO:0010038; GO:0010832; GO:0016032; GO:0016569; GO:0016605; GO:0019899; GO:0019901; GO:0030295; GO:0030521; GO:0030578; GO:0031072; GO:0031396; GO:0031625; GO:0033129; GO:0042393; GO:0042803; GO:0043005; GO:0043065; GO:0044297; GO:0045860; GO:0045892; GO:0047485; GO:0050681; GO:0070603; GO:0071356; GO:0071454; GO:1901216 0 0 cd13151; PF03344; D2GXS7 CHOYP_ACA1_078640.1.1 m.42412 sp TRIM2_AILME 28.448 116 81 1 223 336 627 742 6.39E-07 54.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P42232 CHOYP_STAT1.2.2 m.43480 sp STA5B_MOUSE 24.752 404 222 15 339 717 311 657 6.39E-20 99.4 STA5B_MOUSE reviewed Signal transducer and activator of transcription 5B Stat5b Mus musculus (Mouse) 786 2-oxoglutarate metabolic process [GO:0006103]; acute-phase response [GO:0006953]; allantoin metabolic process [GO:0000255]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hormone stimulus [GO:0032870]; citrate metabolic process [GO:0006101]; creatine metabolic process [GO:0006600]; creatinine metabolic process [GO:0046449]; cytokine-mediated signaling pathway [GO:0019221]; development of secondary female sexual characteristics [GO:0046543]; development of secondary male sexual characteristics [GO:0046544]; fatty acid metabolic process [GO:0006631]; female pregnancy [GO:0007565]; isoleucine metabolic process [GO:0006549]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; lactation [GO:0007595]; lipid storage [GO:0019915]; liver development [GO:0001889]; luteinization [GO:0001553]; mast cell migration [GO:0097531]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; oxaloacetate metabolic process [GO:0006107]; Peyer's patch development [GO:0048541]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cellular component movement [GO:0051272]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 biosynthetic process [GO:0045086]; positive regulation of lymphocyte differentiation [GO:0045621]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; progesterone metabolic process [GO:0042448]; prolactin signaling pathway [GO:0038161]; regulation of cell adhesion [GO:0030155]; regulation of epithelial cell differentiation [GO:0030856]; regulation of multicellular organism growth [GO:0040014]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to interleukin-15 [GO:0070672]; response to interleukin-2 [GO:0070669]; response to interleukin-4 [GO:0070670]; response to lipopolysaccharide [GO:0032496]; sex differentiation [GO:0007548]; succinate metabolic process [GO:0006105]; taurine metabolic process [GO:0019530]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; valine metabolic process [GO:0006573] GO:0000255; GO:0000979; GO:0001077; GO:0001553; GO:0001666; GO:0001779; GO:0001889; GO:0003677; GO:0003682; GO:0004871; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006101; GO:0006103; GO:0006105; GO:0006107; GO:0006357; GO:0006549; GO:0006573; GO:0006600; GO:0006631; GO:0006953; GO:0007259; GO:0007548; GO:0007565; GO:0007595; GO:0008284; GO:0019218; GO:0019221; GO:0019530; GO:0019903; GO:0019915; GO:0030155; GO:0030856; GO:0032355; GO:0032496; GO:0032819; GO:0032825; GO:0032870; GO:0033077; GO:0035259; GO:0038161; GO:0040014; GO:0040018; GO:0042104; GO:0042448; GO:0043029; GO:0043066; GO:0045086; GO:0045471; GO:0045579; GO:0045588; GO:0045621; GO:0045647; GO:0045648; GO:0045931; GO:0045944; GO:0045954; GO:0046449; GO:0046543; GO:0046544; GO:0046983; GO:0048541; GO:0048661; GO:0050729; GO:0051272; GO:0060397; GO:0070669; GO:0070670; GO:0070672; GO:0071363; GO:0071364; GO:0097531 0 0 0 PF00017;PF01017;PF02864;PF02865; P61376 CHOYP_LHX1.2.2 m.31365 sp LHX5_RAT 48.233 481 130 16 1 450 2 394 6.39E-132 390 LHX5_RAT reviewed LIM/homeobox protein Lhx5 (LIM homeobox protein 5) (Homeobox protein LIM-2) Lhx5 Lim-2 Lim2 Rattus norvegicus (Rat) 402 "cell proliferation in forebrain [GO:0021846]; cerebellar Purkinje cell differentiation [GO:0021702]; cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [GO:0021937]; forebrain neuron differentiation [GO:0021879]; hippocampus development [GO:0021766]; positive regulation of transcription, DNA-templated [GO:0045893]; spinal cord association neuron differentiation [GO:0021527]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0008270; GO:0021527; GO:0021702; GO:0021766; GO:0021846; GO:0021879; GO:0021937; GO:0043565; GO:0045893 0 0 0 PF00046;PF00412; P62071 CHOYP_BRAFLDRAFT_199337.1.1 m.25508 sp RRAS2_MOUSE 75.132 189 46 1 3 191 7 194 6.39E-96 280 RRAS2_MOUSE reviewed Ras-related protein R-Ras2 Rras2 Mus musculus (Mouse) 204 cellular process [GO:0009987]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; Ras protein signal transduction [GO:0007265]; regulation of neuron death [GO:1901214] GO:0001649; GO:0005525; GO:0005622; GO:0005886; GO:0005925; GO:0007265; GO:0009987; GO:0016020; GO:0030335; GO:0070062; GO:1901214 0 0 0 PF00071; Q0II25 CHOYP_POP7.2.2 m.46417 sp POP7_BOVIN 58.4 125 45 1 52 169 15 139 6.39E-48 155 POP7_BOVIN reviewed Ribonuclease P protein subunit p20 (RNaseP protein p20) (EC 3.1.26.5) POP7 RPP20 Bos taurus (Bovine) 140 "RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; tRNA processing [GO:0008033]" GO:0004526; GO:0005634; GO:0005730; GO:0005737; GO:0008033; GO:0044822; GO:0090502 0 0 0 PF12328; Q12955 CHOYP_LOC753709.28.44 m.52232 sp ANK3_HUMAN 29.562 707 442 24 13 667 81 783 6.39E-57 213 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q568Z9 CHOYP_CRE_03678.2.3 m.34907 sp PHYIP_RAT 36.598 194 113 4 290 480 140 326 6.39E-27 114 PHYIP_RAT reviewed Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1) Phyhip Rattus norvegicus (Rat) 330 0 0 0 0 0 0 Q5E9A5 CHOYP_DERE_GG23269.1.1 m.10341 sp GA45B_BOVIN 28.846 104 72 1 70 171 19 122 6.39E-10 58.9 GA45B_BOVIN reviewed Growth arrest and DNA damage-inducible protein GADD45 beta GADD45B Bos taurus (Bovine) 160 activation of MAPKK activity [GO:0000186]; activation of MAPKKK activity [GO:0000185]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; regulation of cell cycle [GO:0051726]; response to stress [GO:0006950] GO:0000185; GO:0000186; GO:0005634; GO:0005737; GO:0006469; GO:0006915; GO:0006950; GO:0007275; GO:0030154; GO:0043065; GO:0046330; GO:0051726; GO:1900745 0 0 0 PF01248; Q6ZRF8 CHOYP_LOC100891801.1.1 m.31895 sp RN207_HUMAN 23.348 227 153 8 22 237 117 333 6.39E-08 57.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZUK4 CHOYP_LOC100372311.1.1 m.6654 sp TMM26_HUMAN 32.704 318 184 7 114 405 7 320 6.39E-40 149 TMM26_HUMAN reviewed Transmembrane protein 26 TMEM26 Homo sapiens (Human) 368 0 GO:0016021 0 0 0 PF09772; Q6ZWR6 CHOYP_SYNE2.1.1 m.731 sp SYNE1_MOUSE 26.667 375 229 6 259 587 8424 8798 6.39E-29 126 SYNE1_MOUSE reviewed Nesprin-1 (Enaptin) (Myocyte nuclear envelope protein 1) (Myne-1) (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) Syne1 Mus musculus (Mouse) 8799 cytoskeletal anchoring at nuclear membrane [GO:0090286]; establishment of nucleus localization [GO:0040023]; Golgi organization [GO:0007030]; muscle cell differentiation [GO:0042692]; nuclear matrix anchoring at nuclear membrane [GO:0090292] GO:0003779; GO:0005521; GO:0005634; GO:0005635; GO:0005640; GO:0005654; GO:0005737; GO:0005794; GO:0005856; GO:0007030; GO:0016021; GO:0030017; GO:0031965; GO:0034993; GO:0040023; GO:0042692; GO:0042802; GO:0042803; GO:0044822; GO:0045211; GO:0051015; GO:0090286; GO:0090292 0 0 0 PF00307;PF10541;PF00435; Q8I030 CHOYP_LOC100923499.2.2 m.45829 sp CYTB_PANTR 45.918 98 52 1 13 109 1 98 6.39E-27 98.2 CYTB_PANTR reviewed Cystatin-B (Stefin-B) CSTB STFB Pan troglodytes (Chimpanzee) 98 adult locomotory behavior [GO:0008344] GO:0004869; GO:0005615; GO:0005730; GO:0005737; GO:0008344; GO:0044822; GO:0070062 0 0 0 PF00031; Q8IYF3 CHOYP_LOC797197.1.1 m.49426 sp TEX11_HUMAN 33.635 883 542 15 57 919 68 926 6.39E-148 464 TEX11_HUMAN reviewed Testis-expressed sequence 11 protein TEX11 Homo sapiens (Human) 940 chiasma assembly [GO:0051026]; fertilization [GO:0009566]; male gonad development [GO:0008584]; male meiosis chromosome segregation [GO:0007060]; meiotic gene conversion [GO:0006311]; negative regulation of apoptotic process [GO:0043066]; reciprocal meiotic recombination [GO:0007131]; resolution of meiotic recombination intermediates [GO:0000712]; synaptonemal complex assembly [GO:0007130] GO:0000712; GO:0000801; GO:0006311; GO:0007060; GO:0007130; GO:0007131; GO:0008584; GO:0009566; GO:0043066; GO:0051026 0 0 0 PF08631; Q8N9Z9 CHOYP_LOC100378619.2.2 m.36047 sp LMTD1_HUMAN 31.436 369 190 12 486 832 49 376 6.39E-40 155 LMTD1_HUMAN reviewed Lamin tail domain-containing protein 1 (Intermediate filament tail domain-containing protein 1) LMNTD1 IFLTD1 Homo sapiens (Human) 388 cell proliferation [GO:0008283] GO:0005198; GO:0005635; GO:0005737; GO:0005882; GO:0008283 0 0 0 PF00932; Q8TCB0 CHOYP_BRAFLDRAFT_91636.8.11 m.58992 sp IFI44_HUMAN 35.409 257 164 2 258 513 168 423 6.39E-44 164 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; Q92625 CHOYP_BRAFLDRAFT_127440.1.1 m.34592 sp ANS1A_HUMAN 33.702 181 97 6 10 176 701 872 6.39E-14 76.6 ANS1A_HUMAN reviewed Ankyrin repeat and SAM domain-containing protein 1A (Odin) ANKS1A ANKS1 KIAA0229 ODIN Homo sapiens (Human) 1134 ephrin receptor signaling pathway [GO:0048013]; neuron remodeling [GO:0016322]; regulation of ephrin receptor signaling pathway [GO:1901187]; substrate-dependent cell migration [GO:0006929] GO:0005654; GO:0005737; GO:0006929; GO:0016322; GO:0043005; GO:0048013; GO:1901187 0 0 0 PF12796;PF00640;PF00536;PF07647; Q99LU8 CHOYP_CF062.1.1 m.8738 sp CF062_MOUSE 61.674 227 87 0 1 227 1 227 6.39E-99 290 CF062_MOUSE reviewed Uncharacterized protein C6orf62 homolog 0 Mus musculus (Mouse) 229 0 GO:0005622 0 0 0 PF15130; Q9GZY4 CHOYP_ISCW_ISCW008283.1.1 m.10343 sp COA1_HUMAN 28.049 82 59 0 57 138 46 127 6.39E-07 49.7 COA1_HUMAN reviewed Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa) COA1 C7orf44 MITRAC15 Homo sapiens (Human) 146 mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0005737; GO:0005739; GO:0006412; GO:0022625; GO:0031305; GO:0032981; GO:0033617 0 0 0 PF08695; Q9ULJ7 CHOYP_LOC583072.24.25 m.65759 sp ANR50_HUMAN 32.249 338 224 2 196 528 646 983 6.39E-49 185 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; G5E8K6 CHOYP_LOC100745107.2.3 m.38333 sp MOT6_MOUSE 23.928 443 311 6 9 430 14 451 6.40E-31 127 MOT6_MOUSE reviewed Monocarboxylate transporter 6 (MCT 6) (Monocarboxylate transporter 5) (MCT 5) (Solute carrier family 16 member 5) Slc16a5 Mct5 Mct6 Mus musculus (Mouse) 468 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; O35930 CHOYP_contig_018619 m.21845 sp GP1BA_MOUSE 44.218 147 64 4 374 508 383 523 6.40E-08 60.1 GP1BA_MOUSE reviewed Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (CD antigen CD42b) Gp1ba Mus musculus (Mouse) 734 blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cytokine-mediated signaling pathway [GO:0019221]; fibrinolysis [GO:0042730]; hemostasis [GO:0007599]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469] GO:0000902; GO:0004860; GO:0005737; GO:0005886; GO:0005887; GO:0006469; GO:0007155; GO:0007596; GO:0007599; GO:0009986; GO:0016020; GO:0019221; GO:0031362; GO:0042730; GO:0046426; GO:0070062 0 0 0 PF13855; O70277 CHOYP_BRAFLDRAFT_67269.4.4 m.37388 sp TRIM3_RAT 28.111 217 140 8 343 553 536 742 6.40E-12 72 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P02597 CHOYP_LOC100565534.1.3 m.28075 sp CALMS_CHICK 40.667 150 88 1 1 150 1 149 6.40E-36 124 CALMS_CHICK reviewed "Calmodulin, striated muscle" CCM1 Gallus gallus (Chicken) 149 0 GO:0005509 0 0 0 PF13499; P70677 CHOYP_CASP3.2.3 m.24896 sp CASP3_MOUSE 25.086 291 167 11 11 299 34 275 6.40E-12 68.2 CASP3_MOUSE reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] Casp3 Cpp32 Mus musculus (Mouse) 277 apoptotic process [GO:0006915]; B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to organic cyclic compound [GO:0071407]; cellular response to organic substance [GO:0071310]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; hippocampus development [GO:0021766]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; keratinocyte differentiation [GO:0030216]; learning or memory [GO:0007611]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cell cycle [GO:0045786]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to amino acid [GO:0043200]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to organic substance [GO:0010033]; response to UV [GO:0009411]; response to wounding [GO:0009611]; response to X-ray [GO:0010165]; sensory perception of sound [GO:0007605]; T cell homeostasis [GO:0043029]; wound healing [GO:0042060] GO:0001666; GO:0001782; GO:0004190; GO:0004197; GO:0004252; GO:0004861; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006974; GO:0007507; GO:0007605; GO:0007611; GO:0008233; GO:0008234; GO:0009411; GO:0009611; GO:0009749; GO:0010033; GO:0010165; GO:0016005; GO:0016485; GO:0021766; GO:0030182; GO:0030216; GO:0030218; GO:0030889; GO:0031264; GO:0032025; GO:0032355; GO:0032496; GO:0034349; GO:0035094; GO:0042060; GO:0042493; GO:0042542; GO:0043029; GO:0043066; GO:0043200; GO:0043525; GO:0045121; GO:0045165; GO:0045736; GO:0045786; GO:0046007; GO:0046677; GO:0048011; GO:0051384; GO:0051402; GO:0070059; GO:0071310; GO:0071407; GO:0097153; GO:0097192; GO:0097194; GO:0097200 0 0 0 0 Q3ZBN6 CHOYP_LOC100926902.1.1 m.24455 sp GA45A_BOVIN 28.743 167 106 4 1 157 1 164 6.40E-15 70.9 GA45A_BOVIN reviewed Growth arrest and DNA damage-inducible protein GADD45 alpha GADD45A Bos taurus (Bovine) 165 activation of MAPKKK activity [GO:0000185]; cellular response to ionizing radiation [GO:0071479]; cellular response to mechanical stimulus [GO:0071260]; centrosome cycle [GO:0007098]; mitotic cell cycle arrest [GO:0071850]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; signal transduction in response to DNA damage [GO:0042770] GO:0000185; GO:0001047; GO:0005654; GO:0005737; GO:0006469; GO:0007098; GO:0042770; GO:0043065; GO:0046330; GO:0071260; GO:0071479; GO:0071850; GO:1900745; GO:2000379 0 0 0 PF01248; Q501S4 CHOYP_LOC100493575.1.1 m.47996 sp MET12_DANRE 28.061 196 136 3 1 193 57 250 6.40E-17 79.3 MET12_DANRE reviewed "Methyltransferase-like protein 12, mitochondrial (EC 2.1.1.-)" mettl12 zgc:113305 Danio rerio (Zebrafish) (Brachydanio rerio) 254 0 GO:0005739; GO:0008168 0 0 0 PF13847; Q61382 CHOYP_LOC574808.1.1 m.28998 sp TRAF4_MOUSE 31.515 330 206 4 1 325 155 469 6.40E-54 186 TRAF4_MOUSE reviewed TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1) Traf4 Cart1 Mus musculus (Mouse) 470 apoptotic process [GO:0006915]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of protein kinase activity [GO:0045860]; regulation of apoptotic process [GO:0042981]; respiratory gaseous exchange [GO:0007585]; respiratory tube development [GO:0030323]; signal transduction [GO:0007165] GO:0004842; GO:0005164; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0005923; GO:0006915; GO:0007165; GO:0007585; GO:0008270; GO:0019901; GO:0030323; GO:0031625; GO:0031996; GO:0042981; GO:0045860; GO:0046330; GO:0048471; GO:0050699; GO:0090073 0 0 0 PF00097;PF02176; Q6DIJ4 CHOYP_UBP10.1.1 m.10603 sp UBP10_XENTR 47.852 512 233 12 427 922 311 804 6.40E-148 460 UBP10_XENTR reviewed Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) usp10 TGas137m11.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 805 "autophagy [GO:0006914]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to interleukin-1 [GO:0071347]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; protein deubiquitination [GO:0016579]; regulation of autophagy [GO:0010506]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0002039; GO:0004197; GO:0004843; GO:0005634; GO:0005737; GO:0005769; GO:0006281; GO:0006511; GO:0006914; GO:0006974; GO:0010506; GO:0016579; GO:0030330; GO:0043124; GO:0044325; GO:0071347 0 0 0 PF00443; Q6ZRR7 CHOYP_LOC100372309.1.1 m.66389 sp LRRC9_HUMAN 43.223 273 108 6 1 232 133 399 6.40E-53 186 LRRC9_HUMAN reviewed Leucine-rich repeat-containing protein 9 LRRC9 Homo sapiens (Human) 1453 0 0 0 0 0 0 Q7TNK0 CHOYP_LOC100120039.1.1 m.55929 sp SERC1_RAT 49.474 475 209 7 1 467 1 452 6.40E-159 460 SERC1_RAT reviewed Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2) Serinc1 Tde1l Tde2 Rattus norvegicus (Rat) 453 L-serine transport [GO:0015825]; phosphatidylserine metabolic process [GO:0006658]; phospholipid biosynthetic process [GO:0008654]; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:1904219]; positive regulation of serine C-palmitoyltransferase activity [GO:1904222]; sphingolipid metabolic process [GO:0006665] GO:0005789; GO:0005886; GO:0006658; GO:0006665; GO:0008654; GO:0015194; GO:0015825; GO:0016021; GO:0070062; GO:1904219; GO:1904222 0 0 0 PF03348; Q8BGV0 CHOYP_SYNM.1.1 m.6924 sp SYNM_MOUSE 40.237 169 96 1 34 197 17 185 6.40E-36 134 SYNM_MOUSE reviewed "Probable asparagine--tRNA ligase, mitochondrial (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)" Nars2 Mus musculus (Mouse) 477 asparaginyl-tRNA aminoacylation [GO:0006421] GO:0003676; GO:0004816; GO:0005524; GO:0005739; GO:0005759; GO:0006421 0 0 0 PF00152;PF01336; Q8K0U4 CHOYP_HS12A.16.33 m.50930 sp HS12A_MOUSE 31.79 324 185 10 2 322 305 595 6.40E-43 159 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8W1K8 CHOYP_NEMVEDRAFT_V1G168076.1.2 m.48224 sp MUT11_CHLRE 32.867 143 72 6 92 231 108 229 6.40E-07 53.1 MUT11_CHLRE reviewed Protein Mut11 (Mut11p) Mut11 Chlamydomonas reinhardtii (Chlamydomonas smithii) 370 0 GO:0005634 0 0 0 PF00400; Q9BT23 CHOYP_LOC100877689.2.2 m.26187 sp LIMD2_HUMAN 52.564 78 37 0 1151 1228 38 115 6.40E-24 101 LIMD2_HUMAN reviewed LIM domain-containing protein 2 LIMD2 SB143 Homo sapiens (Human) 127 0 GO:0008270 0 0 0 PF00412; Q9VVE2 CHOYP_LOC100901761.1.1 m.15275 sp ROGDI_DROME 38.8 250 140 6 2 251 6 242 6.40E-51 172 ROGDI_DROME reviewed Protein rogdi rogdi CG7725 Drosophila melanogaster (Fruit fly) 268 behavioral response to ethanol [GO:0048149]; learning or memory [GO:0007611]; olfactory learning [GO:0008355] GO:0005635; GO:0007611; GO:0008355; GO:0048149 0 0 0 PF10259; Q9Y5G0 CHOYP_PCDGH.1.1 m.12317 sp PCDGH_HUMAN 36.278 317 190 6 24 340 35 339 6.40E-50 181 PCDGH_HUMAN reviewed Protocadherin gamma-B5 (PCDH-gamma-B5) PCDHGB5 Homo sapiens (Human) 923 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0070062 0 0 0 PF00028;PF08266;PF16492;PF15974; A6QP79 CHOYP_CD209.4.6 m.50478 sp COL12_BOVIN 31.034 145 84 6 67 198 590 731 6.41E-10 61.2 COL12_BOVIN reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) COLEC12 CLP1 Bos taurus (Bovine) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; D8VNT0 CHOYP_LOC100637173.1.1 m.61870 sp FCNV4_CERRY 47.847 209 101 4 338 541 136 341 6.41E-49 175 FCNV4_CERRY reviewed Ryncolin-4 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; E9Q555 CHOYP_RN213.6.13 m.42269 sp RN213_MOUSE 28.197 1337 866 37 4 1306 3863 5139 6.41E-148 501 RN213_MOUSE reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin) (RING finger protein 213) Rnf213 Mystr Mus musculus (Mouse) 5152 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O75197 CHOYP_LRP5.1.3 m.18025 sp LRP5_HUMAN 28.664 614 367 20 242 845 330 882 6.41E-57 217 LRP5_HUMAN reviewed Low-density lipoprotein receptor-related protein 5 (LRP-5) LRP5 LR3 LRP7 Homo sapiens (Human) 1615 "adipose tissue development [GO:0060612]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in patterning of blood vessels [GO:1902262]; beta-catenin destruction complex disassembly [GO:1904886]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling involved in mammary gland development [GO:0060764]; cell migration involved in gastrulation [GO:0042074]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; glucose catabolic process [GO:0006007]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; osteoblast development [GO:0002076]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of bone remodeling [GO:0046850]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; retinal blood vessel morphogenesis [GO:0061304]; retina morphogenesis in camera-type eye [GO:0060042]; somatic stem cell population maintenance [GO:0035019]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]" GO:0001702; GO:0002053; GO:0002076; GO:0005739; GO:0005783; GO:0005886; GO:0006007; GO:0006897; GO:0008203; GO:0008217; GO:0008284; GO:0009952; GO:0016021; GO:0016055; GO:0017147; GO:0033690; GO:0035019; GO:0035426; GO:0042074; GO:0042632; GO:0042733; GO:0042813; GO:0042981; GO:0043235; GO:0044332; GO:0045600; GO:0045668; GO:0045840; GO:0045893; GO:0045944; GO:0046849; GO:0046850; GO:0048539; GO:0051091; GO:0060033; GO:0060042; GO:0060070; GO:0060349; GO:0060444; GO:0060612; GO:0060764; GO:0060828; GO:0061178; GO:0061304; GO:0071901; GO:0071936; GO:1902262; GO:1904886; GO:1904928; GO:1990851; GO:1990909 0 0 0 PF00057;PF00058; P18433 CHOYP_BRAFLDRAFT_59175.2.2 m.53473 sp PTPRA_HUMAN 28.99 683 438 18 414 1069 138 800 6.41E-75 267 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P28034 CHOYP_CAL6303_3579.1.1 m.59031 sp CAMT_PETCR 34.978 223 131 5 61 271 20 240 6.41E-28 110 CAMT_PETCR reviewed Caffeoyl-CoA O-methyltransferase (EC 2.1.1.104) (Trans-caffeoyl-CoA 3-O-methyltransferase) (CCoAMT) (CCoAOMT) 0 Petroselinum crispum (Parsley) (Petroselinum hortense) 241 lignin biosynthetic process [GO:0009809] GO:0009809; GO:0042409; GO:0046872 PATHWAY: Aromatic compound metabolism; phenylpropanoid biosynthesis. 0 0 PF01596; P47967 CHOYP_LOC100378653.3.3 m.64189 sp LEG5_RAT 45.255 137 66 3 415 550 15 143 6.41E-27 109 LEG5_RAT reviewed Galectin-5 (Gal-5) (RL-18) Lgals5 Rattus norvegicus (Rat) 145 0 GO:0030246 0 0 0 PF00337; Q0IES8 CHOYP_LOC100370446.3.12 m.24546 sp MAB21_AEDAE 24.528 265 173 8 111 368 92 336 6.41E-09 61.2 MAB21_AEDAE reviewed Protein mab-21 mab-21 AAEL008118 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 365 0 GO:0005634 0 0 0 PF03281; Q0V9W6 CHOYP_BTBD6.6.6 m.55036 sp BTBD6_XENTR 33.647 425 269 10 5 419 106 527 6.41E-60 207 BTBD6_XENTR reviewed BTB/POZ domain-containing protein 6 btbd6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 529 0 GO:0000932 0 0 0 PF07707;PF00651;PF08005; Q15063 CHOYP_BRAFLDRAFT_127065.3.7 m.15669 sp POSTN_HUMAN 32.692 260 170 5 28 283 109 367 6.41E-32 127 POSTN_HUMAN reviewed Periostin (PN) (Osteoblast-specific factor 2) (OSF-2) POSTN OSF2 Homo sapiens (Human) 836 bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-C motif) ligand 2 secretion [GO:1904209]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; skeletal system development [GO:0001501] GO:0001501; GO:0001666; GO:0001953; GO:0003073; GO:0005578; GO:0005615; GO:0005802; GO:0007155; GO:0008201; GO:0008593; GO:0009612; GO:0014850; GO:0014911; GO:0030198; GO:0031012; GO:0031594; GO:0032355; GO:0044344; GO:0046872; GO:0050839; GO:0071307; GO:0071356; GO:0071560; GO:1900025; GO:1904209; GO:1990138; GO:1990523 0 0 0 PF02469; Q3ZBL5 CHOYP_PTH2.1.1 m.5380 sp PTH2_BOVIN 52.727 165 76 2 31 195 16 178 6.41E-55 175 PTH2_BOVIN reviewed "Peptidyl-tRNA hydrolase 2, mitochondrial (PTH 2) (EC 3.1.1.29) (Bcl-2 inhibitor of transcription)" PTRH2 BIT1 Bos taurus (Bovine) 179 0 GO:0004045; GO:0005739 0 0 0 PF01981; Q6GPQ6 CHOYP_SI_CH211-197G15.10.6.7 m.50389 sp EDF1_XENLA 61.644 146 55 1 382 526 1 146 6.41E-55 184 EDF1_XENLA reviewed Endothelial differentiation-related factor 1 homolog (EDF-1) edf1 Xenopus laevis (African clawed frog) 147 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0043565 0 0 0 PF01381;PF08523; Q6PFY8 CHOYP_LOC100375954.6.6 m.65484 sp TRI45_MOUSE 30.392 204 120 7 5 195 127 321 6.41E-14 77.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8ISH7 CHOYP_CBG11292.1.1 m.12957 sp FCAP_APLCA 37.533 381 146 16 133 423 293 671 6.41E-46 172 FCAP_APLCA reviewed Feeding circuit activating peptides (FCAP) [Cleaved into: Feeding circuit activating peptide a (FCAPa); Feeding circuit activating peptide b (FCAPb); Feeding circuit activating peptide c (FCAPc); Feeding circuit activating peptide d (FCAPd); Feeding circuit activating peptide e (FCAPe); Feeding circuit activating peptide f (FCAPf); Feeding circuit activating peptide g (FCAPg); Feeding circuit activating peptide h (FCAPh)] 0 Aplysia californica (California sea hare) 742 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 0 Q8IXZ2 CHOYP_LOC101168697.2.2 m.10478 sp ZC3H3_HUMAN 59.146 164 64 2 587 747 644 807 6.41E-62 229 ZC3H3_HUMAN reviewed Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) ZC3H3 KIAA0150 SMICL ZC3HDC3 Homo sapiens (Human) 948 mRNA polyadenylation [GO:0006378]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of activin receptor signaling pathway [GO:0032927]; regulation of mRNA export from nucleus [GO:0010793] GO:0003677; GO:0005634; GO:0005847; GO:0006378; GO:0010793; GO:0016973; GO:0032927; GO:0046872 0 0 0 PF00642; Q92804 CHOYP_RARB.2.3 m.19589 sp RBP56_HUMAN 36.667 330 146 10 9 315 28 317 6.41E-32 128 RBP56_HUMAN reviewed TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) TAF15 RBP56 TAF2N Homo sapiens (Human) 592 "positive regulation of transcription, DNA-templated [GO:0045893]" GO:0000166; GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0044822; GO:0045893 0 0 0 PF00076;PF00641; Q9D3W1 CHOYP_BRAFLDRAFT_279978.1.1 m.30960 sp RSP14_MOUSE 46.667 345 176 4 137 477 1 341 6.41E-99 303 RSP14_MOUSE reviewed Radial spoke head 14 homolog (Rhabdoid tumor deletion region protein 1) Rsph14 Rtdr1 Mus musculus (Mouse) 341 0 0 0 0 0 PF00514; A4QMS7 CHOYP_LOC100374242.1.2 m.46929 sp CE049_HUMAN 37.895 95 56 1 69 163 36 127 6.42E-13 65.5 CE049_HUMAN reviewed Uncharacterized protein C5orf49 C5orf49 Homo sapiens (Human) 147 0 0 0 0 0 PF15074; A7YVD7 CHOYP_LOC100358419.1.1 m.30764 sp NDUF6_BOVIN 40.476 294 166 5 38 326 44 333 6.42E-72 229 NDUF6_BOVIN reviewed "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6" NDUFAF6 Bos taurus (Bovine) 333 biosynthetic process [GO:0009058]; mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0005634; GO:0005739; GO:0005743; GO:0009058; GO:0016021; GO:0016740; GO:0022857; GO:0032981 0 0 0 PF00494; O70277 CHOYP_BRAFLDRAFT_87340.3.6 m.42076 sp TRIM3_RAT 25.984 127 87 3 66 190 622 743 6.42E-07 53.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_LOC583072.13.25 m.47280 sp ANR17_HUMAN 40.127 157 86 5 37 188 468 621 6.42E-21 93.2 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_BRAFLDRAFT_88223.4.22 m.23620 sp TRIM3_HUMAN 26.407 231 127 10 250 471 525 721 6.42E-07 55.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O75897 CHOYP_ST1C2.1.1 m.65005 sp ST1C4_HUMAN 33.488 215 126 8 40 241 30 240 6.42E-23 98.2 ST1C4_HUMAN reviewed Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2) SULT1C4 SULT1C2 Homo sapiens (Human) 302 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; sulfation [GO:0051923] GO:0004062; GO:0005829; GO:0008146; GO:0050427; GO:0051923 0 0 0 PF00685; P16157 CHOYP_LOC100882592.1.1 m.55645 sp ANK1_HUMAN 33.747 403 267 0 88 490 372 774 6.42E-60 221 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P42678 CHOYP_EIF1B.3.3 m.61333 sp SUI1_ANOGA 70.192 104 30 1 66 169 8 110 6.42E-48 154 SUI1_ANOGA reviewed Protein translation factor SUI1 homolog AGAP006459 Anopheles gambiae (African malaria mosquito) 110 regulation of translation [GO:0006417] GO:0003743; GO:0006417 0 0 cd11566; PF01253; P62282 CHOYP_RPS11.1.5 m.11990 sp RS11_RAT 74.051 158 38 3 6 161 1 157 6.42E-82 242 RS11_RAT reviewed 40S ribosomal protein S11 Rps11 Rattus norvegicus (Rat) 158 osteoblast differentiation [GO:0001649]; translation [GO:0006412] GO:0001649; GO:0003735; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022627; GO:0044822; GO:0070062 0 0 0 PF00366;PF16205; P97500 CHOYP_LOC100313656.1.1 m.31026 sp MYT1L_MOUSE 47.083 240 116 5 1 238 929 1159 6.42E-65 222 MYT1L_MOUSE reviewed Myelin transcription factor 1-like protein (MyT1-L) (MyT1L) (Neural zinc finger factor 1) (NZF-1) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) Myt1l Kiaa1106 Nzf1 Png1 Mus musculus (Mouse) 1187 "cell differentiation [GO:0030154]; nervous system development [GO:0007399]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007399; GO:0008270; GO:0030154 0 0 0 PF08474;PF01530; Q5R5N4 CHOYP_LOC100743733.1.1 m.2060 sp MET14_PONAB 59.639 332 122 5 404 723 9 340 6.42E-133 403 MET14_PONAB reviewed N6-adenosine-methyltransferase subunit METTL14 (EC 2.1.1.62) (Methyltransferase-like protein 14) METTL14 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 456 "mRNA destabilization [GO:0061157]; mRNA methylation [GO:0080009]; mRNA splicing, via spliceosome [GO:0000398]; RNA methylation [GO:0001510]; stem cell population maintenance [GO:0019827]" GO:0000398; GO:0001510; GO:0003729; GO:0005634; GO:0016422; GO:0019827; GO:0036396; GO:0061157; GO:0080009 0 0 0 PF05063; Q5T5J6 CHOYP_SWT1.1.1 m.53434 sp SWT1_HUMAN 30.248 443 274 9 216 642 385 808 6.42E-44 173 SWT1_HUMAN reviewed Transcriptional protein SWT1 SWT1 C1orf26 Homo sapiens (Human) 900 0 0 0 0 0 PF13638; Q60847 CHOYP_LOC100558670.1.1 m.29908 sp COCA1_MOUSE 31.98 197 126 4 21 217 135 323 6.42E-19 91.7 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q6DFQ5 CHOYP_TMM97.1.1 m.16413 sp TMM97_XENTR 53.614 166 75 1 3 168 6 169 6.42E-50 161 TMM97_XENTR reviewed Transmembrane protein 97 tmem97 TEgg113g04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 171 cholesterol homeostasis [GO:0042632] GO:0005764; GO:0005791; GO:0005886; GO:0016021; GO:0031965; GO:0042632 0 0 0 0 Q80V70 CHOYP_MEGF6.14.59 m.24310 sp MEGF6_MOUSE 29.767 514 310 16 11 497 703 1192 6.42E-36 146 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8CC88 CHOYP_VWA8.3.3 m.29910 sp VWA8_MOUSE 63.218 174 64 0 18 191 25 198 6.42E-68 227 VWA8_MOUSE reviewed von Willebrand factor A domain-containing protein 8 Vwa8 Kiaa0564 Mus musculus (Mouse) 1905 0 GO:0005524; GO:0005576; GO:0005739; GO:0016887 0 0 0 PF07728; Q8CGS4 CHOYP_CHMP3.1.1 m.65684 sp CHMP3_RAT 65.471 223 69 2 1 215 1 223 6.42E-92 271 CHMP3_RAT reviewed Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Vacuolar protein sorting-associated protein 24) (rVps24p) Chmp3 Vps24 Rattus norvegicus (Rat) 223 cell cycle [GO:0007049]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; positive regulation of cytokinesis [GO:0032467]; protein transport [GO:0015031]; regulation of endosome size [GO:0051036] GO:0000815; GO:0005546; GO:0005769; GO:0005770; GO:0005829; GO:0007049; GO:0008333; GO:0015031; GO:0030496; GO:0031902; GO:0032467; GO:0051036; GO:0051301 0 0 0 PF03357; Q8NBJ4 CHOYP_LOC100373083.1.2 m.19988 sp GOLM1_HUMAN 26.277 137 94 2 11 143 5 138 6.42E-07 54.7 GOLM1_HUMAN reviewed Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326 Homo sapiens (Human) 401 nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216] GO:0005615; GO:0005794; GO:0005887; GO:0006997; GO:0019216; GO:0070062 0 0 0 0 Q8R1B8 CHOYP_NR1D2.2.2 m.36518 sp RORB_MOUSE 26.244 442 277 10 40 468 16 421 6.42E-28 119 RORB_MOUSE reviewed Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) Rorb Nr1f2 Mus musculus (Mouse) 470 "amacrine cell differentiation [GO:0035881]; brain development [GO:0007420]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; eye photoreceptor cell development [GO:0042462]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; transcription, DNA-templated [GO:0006351]; visual perception [GO:0007601]" GO:0003700; GO:0003707; GO:0004879; GO:0005634; GO:0006351; GO:0007420; GO:0007601; GO:0007623; GO:0008134; GO:0008270; GO:0008502; GO:0035881; GO:0042462; GO:0042752; GO:0043565; GO:0045668; GO:0045892; GO:0045893; GO:0046548; GO:0046549; GO:0060041; GO:0071300 0 0 0 PF00104;PF00105; Q923G2 CHOYP_RPAB3.2.4 m.30639 sp RPAB3_MOUSE 85.333 150 21 1 1 149 1 150 6.42E-89 258 RPAB3_MOUSE reviewed "DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (RPB17) (RPB8 homolog)" Polr2h Mus musculus (Mouse) 150 piRNA metabolic process [GO:0034587]; transcription from RNA polymerase III promoter [GO:0006383]; transcription from RNA polymerase II promoter [GO:0006366]; transcription from RNA polymerase I promoter [GO:0006360] GO:0003677; GO:0003899; GO:0005634; GO:0005654; GO:0005665; GO:0005666; GO:0005736; GO:0006360; GO:0006366; GO:0006383; GO:0034587 0 0 0 PF03870; Q9VUL9 CHOYP_FUCTA.3.4 m.21442 sp FUCTA_DROME 34.419 215 123 7 21 228 300 503 6.42E-29 116 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; O75339 CHOYP_BRAFLDRAFT_96564.1.1 m.4500 sp CILP1_HUMAN 23.546 361 209 17 66 371 752 1100 6.43E-06 52 CILP1_HUMAN reviewed Cartilage intermediate layer protein 1 (CILP-1) (Cartilage intermediate-layer protein) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] CILP UNQ602/PRO1188 Homo sapiens (Human) 1184 negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569] GO:0005578; GO:0005615; GO:0031012; GO:0043569; GO:0070062 0 0 0 PF13330;PF00090; P27987 CHOYP_LOC590949.1.2 m.13540 sp IP3KB_HUMAN 54.026 385 161 4 362 738 566 942 6.43E-129 409 IP3KB_HUMAN reviewed "Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B)" ITPKB Homo sapiens (Human) 946 cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; common myeloid progenitor cell proliferation [GO:0035726]; inositol phosphate metabolic process [GO:0043647]; inositol trisphosphate metabolic process [GO:0032957]; MAPK cascade [GO:0000165]; myeloid cell homeostasis [GO:0002262]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of neutrophil apoptotic process [GO:0033030]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of Ras protein signal transduction [GO:0046579]; positive thymic T cell selection [GO:0045059]; regulation of protein phosphorylation [GO:0001932]; signal transduction [GO:0007165] GO:0000165; GO:0001932; GO:0002262; GO:0005524; GO:0005634; GO:0005829; GO:0007165; GO:0007166; GO:0008440; GO:0016020; GO:0032957; GO:0033030; GO:0035726; GO:0043647; GO:0045059; GO:0045638; GO:0046579; GO:0046638; GO:0071277 0 0 0 PF03770; P43028 CHOYP_BRAFLDRAFT_80287.1.1 m.33178 sp GDF6_MOUSE 28.182 440 223 16 63 484 89 453 6.43E-40 152 GDF6_MOUSE reviewed Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16) Gdf6 Bmp13 Gdf-6 Gdf16 Mus musculus (Mouse) 454 "activin receptor signaling pathway [GO:0032924]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; fat cell differentiation [GO:0045444]; growth [GO:0040007]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of apoptotic process [GO:0042981]; retinal cell apoptotic process [GO:1990009]; SMAD protein signal transduction [GO:0060395]" GO:0005125; GO:0005160; GO:0005615; GO:0006915; GO:0010862; GO:0030509; GO:0032332; GO:0032924; GO:0040007; GO:0042803; GO:0042981; GO:0045444; GO:0045666; GO:0045893; GO:0060389; GO:0060395; GO:1900745; GO:1990009 0 0 0 PF00019;PF00688; P84175 CHOYP_LOC100376688.1.8 m.12067 sp RS12_CHICK 81.89 127 23 0 11 137 6 132 6.43E-73 216 RS12_CHICK reviewed 40S ribosomal protein S12 RPS12 Gallus gallus (Chicken) 132 translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0044822 0 0 0 PF01248; P84175 CHOYP_LOC100376688.2.8 m.15638 sp RS12_CHICK 81.89 127 23 0 11 137 6 132 6.43E-73 216 RS12_CHICK reviewed 40S ribosomal protein S12 RPS12 Gallus gallus (Chicken) 132 translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0044822 0 0 0 PF01248; P84175 CHOYP_Y059.1.1 m.26786 sp RS12_CHICK 81.89 127 23 0 11 137 6 132 6.43E-73 216 RS12_CHICK reviewed 40S ribosomal protein S12 RPS12 Gallus gallus (Chicken) 132 translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0044822 0 0 0 PF01248; Q3SZQ6 CHOYP_BRAFLDRAFT_114866.2.5 m.11126 sp RL32_BOVIN 78.462 130 28 0 21 150 3 132 6.43E-72 216 RL32_BOVIN reviewed 60S ribosomal protein L32 RPL32 Bos taurus (Bovine) 135 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 cd00513; PF01655; Q54CQ8 CHOYP_NEMVEDRAFT_V1G92763.1.1 m.64526 sp Y2740_DICDI 43.537 147 81 2 10 154 346 492 6.43E-35 132 Y2740_DICDI reviewed von Willebrand factor A domain-containing protein DDB_G0292740 DDB_G0292740 Dictyostelium discoideum (Slime mold) 910 0 0 0 0 0 PF08487;PF13768; Q61555 CHOYP_LOC100374579.3.3 m.42645 sp FBN2_MOUSE 32.091 832 444 31 281 1013 1823 2632 6.43E-81 297 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q6PFX9 CHOYP_LOC100877947.1.1 m.51907 sp TNKS1_MOUSE 29.762 252 123 10 55 260 277 520 6.43E-13 77 TNKS1_MOUSE reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (TRF1-interacting ankyrin-related ADP-ribose polymerase 1) (Tankyrase I) Tnks Tnks1 Mus musculus (Mouse) 1320 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; Q7TS63 CHOYP_PHUM_PHUM446350.2.2 m.25485 sp ZFAT_MOUSE 31.469 143 86 4 103 242 902 1035 6.43E-09 63.5 ZFAT_MOUSE reviewed Zinc finger protein ZFAT (Zinc finger protein 406) Zfat Gm922 Zfat1 Zfp406 Znf406 Mus musculus (Mouse) 1237 hematopoietic progenitor cell differentiation [GO:0002244]; hemopoiesis [GO:0030097]; spongiotrophoblast layer development [GO:0060712] GO:0000977; GO:0001077; GO:0002244; GO:0005634; GO:0005829; GO:0030097; GO:0046872; GO:0060712 0 0 0 0 Q80TC5 CHOYP_PMFBP.1.1 m.23873 sp POGK_MOUSE 40.625 128 72 3 554 678 197 323 6.43E-19 95.5 POGK_MOUSE reviewed Pogo transposable element with KRAB domain Pogk Kiaa1513 Mus musculus (Mouse) 607 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q8BWQ5 CHOYP_DICPUDRAFT_77168.1.2 m.21178 sp DCLK3_MOUSE 27.315 216 115 8 399 600 520 707 6.43E-14 79.7 DCLK3_MOUSE reviewed Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (CLICK-I and II-related) (CLr) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) Dclk3 Dcamkl3 Mus musculus (Mouse) 790 intracellular signal transduction [GO:0035556]; negative regulation of protein localization to nucleus [GO:1900181]; peptidyl-serine phosphorylation [GO:0018105] GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0018105; GO:0035556; GO:1900181 0 0 0 PF03607;PF00069; Q99996 CHOYP_LOC582174.8.16 m.39239 sp AKAP9_HUMAN 46.552 58 27 1 48 105 3584 3637 6.43E-07 49.7 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9UBQ7 CHOYP_GRHPR.1.1 m.48129 sp GRHPR_HUMAN 47.231 307 158 2 123 425 8 314 6.43E-94 288 GRHPR_HUMAN reviewed Glyoxylate reductase/hydroxypyruvate reductase (EC 1.1.1.79) (EC 1.1.1.81) GRHPR GLXR MSTP035 Homo sapiens (Human) 328 dicarboxylic acid metabolic process [GO:0043648]; excretion [GO:0007588]; glyoxylate metabolic process [GO:0046487]; metabolic process [GO:0008152]; oxidation-reduction process [GO:0055114]; protein oligomerization [GO:0051259] GO:0005737; GO:0005782; GO:0005829; GO:0007588; GO:0008152; GO:0008465; GO:0016618; GO:0030267; GO:0031406; GO:0042803; GO:0043648; GO:0046487; GO:0051259; GO:0051287; GO:0055114; GO:0070062; GO:0070402 0 0 0 PF00389;PF02826; Q9Y2W6 CHOYP_LOC580618.1.1 m.24550 sp TDRKH_HUMAN 41.83 153 82 4 834 984 308 455 6.43E-27 120 TDRKH_HUMAN reviewed Tudor and KH domain-containing protein (Tudor domain-containing protein 2) TDRKH TDRD2 Homo sapiens (Human) 561 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0003723; GO:0005739; GO:0007140; GO:0007283; GO:0009566; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:0071546; GO:0071547 0 0 0 PF00013;PF00567; A0A0R4IBK5 CHOYP_BRAFLDRAFT_68766.2.4 m.6055 sp R213A_DANRE 35.862 290 161 6 1 290 1500 1764 6.44E-45 171 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 P30028 CHOYP_LOC100494049.5.8 m.61114 sp DPOL_HPBDC 29.091 165 112 4 282 445 446 606 6.44E-11 69.3 DPOL_HPBDC reviewed Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (strain China) (DHBV) 787 DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006260; GO:0046872 0 0 0 PF00336;PF00242;PF00078; Q05A80 CHOYP_C1QT3.8.8 m.50404 sp CAPR2_MOUSE 31.25 144 89 4 91 232 893 1028 6.44E-12 68.2 CAPR2_MOUSE reviewed Caprin-2 (C1q domain-containing protein 1) (Cytoplasmic activation/proliferation-associated protein 2) (RNA granule protein 140) Caprin2 C1qdc1 Kiaa1873 Rng140 Mus musculus (Mouse) 1031 negative regulation of cell growth [GO:0030308]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0003723; GO:0005102; GO:0005634; GO:0005737; GO:0005739; GO:0005813; GO:0017148; GO:0030308; GO:0032092; GO:0033138; GO:0043235; GO:0045944; GO:0050775; GO:0061003; GO:0090263 0 0 0 PF00386;PF12287; Q15399 CHOYP_BRAFLDRAFT_89683.5.5 m.61443 sp TLR1_HUMAN 31.081 148 88 5 67 202 617 762 6.44E-07 55.8 TLR1_HUMAN reviewed Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) TLR1 KIAA0012 Homo sapiens (Human) 786 cellular response to triacyl bacterial lipopeptide [GO:0071727]; defense response to bacterium [GO:0042742]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; toll-like receptor 1 signaling pathway [GO:0034130]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0016020; GO:0030670; GO:0034130; GO:0035354; GO:0035663; GO:0038123; GO:0042116; GO:0042495; GO:0042535; GO:0042742; GO:0045087; GO:0045121; GO:0045410; GO:0046982; GO:0050707; GO:0071723; GO:0071727 0 0 0 PF13855;PF01463;PF01582; Q460N5 CHOYP_PAR15.2.6 m.21083 sp PAR14_HUMAN 34.228 149 96 2 30 176 1012 1160 6.44E-19 87.8 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q80T91 CHOYP_MEGF6.51.59 m.53128 sp MEG11_MOUSE 38.462 156 84 6 192 344 705 851 6.44E-18 89.7 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q92038 CHOYP_ACOD.5.8 m.37925 sp ACOD_CYPCA 64.087 323 109 4 33 349 2 323 6.44E-147 420 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; Q9V9A8 CHOYP_PHTF2.1.1 m.10109 sp PHTF_DROME 52.754 345 145 3 561 888 527 870 6.44E-111 364 PHTF_DROME reviewed Putative homeodomain transcription factor phtf CG3268 Drosophila melanogaster (Fruit fly) 880 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0046983 0 0 0 PF12129; Q9VAU9 CHOYP_ZN330.2.2 m.18093 sp ZN330_DROME 69.106 246 76 0 19 264 1 246 6.44E-125 363 ZN330_DROME reviewed Zinc finger protein 330 homolog (Nucleolar autoantigen 36 homolog) Noa36 CG10009 Drosophila melanogaster (Fruit fly) 315 larval lymph gland hemopoiesis [GO:0035167] GO:0000775; GO:0005730; GO:0008270; GO:0030496; GO:0035167 0 0 0 PF06524; O75351 CHOYP_VPS4B.1.2 m.23772 sp VPS4B_HUMAN 44.151 265 126 5 49 292 170 433 6.45E-70 226 VPS4B_HUMAN reviewed Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) VPS4B SKD1 VPS42 MIG1 Homo sapiens (Human) 444 autophagy [GO:0006914]; cell separation after cytokinesis [GO:0000920]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; late endosomal microautophagy [GO:0061738]; mitotic metaphase plate congression [GO:0007080]; multivesicular body assembly [GO:0036258]; negative regulation of cell death [GO:0060548]; negative regulation of exosomal secretion [GO:1903542]; nucleus organization [GO:0006997]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of viral life cycle [GO:1903902]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of viral process [GO:0050792]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vacuole organization [GO:0007033]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]; viral release from host cell [GO:0019076] GO:0000920; GO:0000922; GO:0005524; GO:0005634; GO:0005737; GO:0005768; GO:0005813; GO:0005829; GO:0006813; GO:0006914; GO:0006997; GO:0007033; GO:0007080; GO:0008022; GO:0010008; GO:0010824; GO:0010971; GO:0015031; GO:0016197; GO:0016887; GO:0019058; GO:0019076; GO:0030301; GO:0031902; GO:0032510; GO:0033993; GO:0036258; GO:0039702; GO:0042623; GO:0042802; GO:0042803; GO:0043162; GO:0048524; GO:0050792; GO:0051261; GO:0060548; GO:0061738; GO:0070062; GO:0090543; GO:0090611; GO:1901673; GO:1902188; GO:1903542; GO:1903543; GO:1903724; GO:1903902; GO:1904903 0 0 0 PF00004;PF04212;PF09336; P0C0T2 CHOYP_LOC100378344.1.1 m.36876 sp ANKS6_RAT 38.074 893 431 24 7 803 13 879 6.45E-152 469 ANKS6_RAT reviewed Ankyrin repeat and SAM domain-containing protein 6 (Polycystic kidney disease protein 1) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) Anks6 Pkdr1 Samd6 Rattus norvegicus (Rat) 885 0 GO:0005737; GO:0005929; GO:0042803 0 0 0 PF12796;PF00536; P49442 CHOYP_LOC101154772.1.1 m.55397 sp INPP_MOUSE 43.264 386 195 8 8 376 4 382 6.45E-102 310 INPP_MOUSE reviewed Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) Inpp1 Mus musculus (Mouse) 396 inositol phosphate dephosphorylation [GO:0046855]; phosphatidylinositol phosphorylation [GO:0046854]; signal transduction [GO:0007165] GO:0000287; GO:0004441; GO:0005737; GO:0007165; GO:0046854; GO:0046855 PATHWAY: Signal transduction; phosphatidylinositol signaling pathway. 0 0 PF00459; Q09621 CHOYP_LOC575771.1.3 m.18169 sp LACT2_CAEEL 32 400 256 8 43 435 66 456 6.45E-59 203 LACT2_CAEEL reviewed Beta-lactamase domain-containing protein 2 lact-2 ZK945.1 Caenorhabditis elegans 473 0 GO:0016021 0 0 0 PF00144; Q24K15 CHOYP_FBCD1.2.3 m.52341 sp ANGP4_BOVIN 42.241 232 127 4 57 284 266 494 6.45E-57 193 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q28864 CHOYP_LOC100371332.6.6 m.65822 sp TFPI1_MACMU 40.602 133 65 2 936 1056 46 176 6.45E-24 107 TFPI1_MACMU reviewed Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI TFPI1 Macaca mulatta (Rhesus macaque) 304 blood coagulation [GO:0007596] GO:0004867; GO:0005615; GO:0007596; GO:0009986 0 0 0 PF00014; Q2KIY1 CHOYP_LOC100368884.1.1 m.50320 sp PXMP2_BOVIN 43.575 179 94 2 14 189 19 193 6.45E-47 155 PXMP2_BOVIN reviewed Peroxisomal membrane protein 2 PXMP2 Bos taurus (Bovine) 196 0 GO:0005778; GO:0016021; GO:0043234 0 0 0 PF04117; Q5XJ85 CHOYP_BRAFLDRAFT_84994.1.1 m.4753 sp MYD88_DANRE 38.636 132 74 4 6 133 149 277 6.45E-18 82 MYD88_DANRE reviewed Myeloid differentiation primary response protein MyD88 myd88 Danio rerio (Zebrafish) (Brachydanio rerio) 284 activation of innate immune response [GO:0002218]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil chemotaxis [GO:0030593]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; response to molecule of bacterial origin [GO:0002237] GO:0002218; GO:0002237; GO:0002755; GO:0005737; GO:0006954; GO:0030593; GO:0043123; GO:0045087; GO:1901532; GO:1901534 0 0 0 PF00531;PF01582; Q7ZV82 CHOYP_SMC2.1.4 m.17838 sp RL27_DANRE 80.198 101 20 0 54 154 35 135 6.45E-56 174 RL27_DANRE reviewed 60S ribosomal protein L27 rpl27 zgc:56171 Danio rerio (Zebrafish) (Brachydanio rerio) 136 erythrocyte differentiation [GO:0030218]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625; GO:0030218 0 0 0 PF00467;PF01777; Q8NI08 CHOYP_LOC655529.2.3 m.40718 sp NCOA7_HUMAN 44.262 366 175 7 339 691 592 941 6.45E-92 309 NCOA7_HUMAN reviewed Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) NCOA7 ERAP140 ESNA1 Nbla00052 Nbla10993 Homo sapiens (Human) 942 "positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0005622; GO:0005634; GO:0006351; GO:0030374; GO:0035257; GO:0045944 0 0 0 PF01476;PF07534; Q91642 CHOYP_BRAFLDRAFT_279226.1.1 m.24471 sp PEPE_XENLA 69.328 238 72 1 1 237 4 241 6.45E-119 341 PEPE_XENLA reviewed Alpha-aspartyl dipeptidase (EC 3.4.13.21) (Asp-specific dipeptidase) (Dipeptidase E) aad-a Xenopus laevis (African clawed frog) 242 0 GO:0005737; GO:0008236; GO:0016805 0 0 0 PF03575; Q91V92 CHOYP_LOC100377487.1.1 m.27964 sp ACLY_MOUSE 61 100 36 2 1 97 1 100 6.45E-31 117 ACLY_MOUSE reviewed ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) Acly Mus musculus (Mouse) 1091 acetyl-CoA biosynthetic process [GO:0006085]; citrate metabolic process [GO:0006101]; lipid biosynthetic process [GO:0008610]; oxaloacetate metabolic process [GO:0006107] GO:0003878; GO:0005524; GO:0005654; GO:0005737; GO:0005739; GO:0005886; GO:0006085; GO:0006101; GO:0006107; GO:0008610; GO:0016020; GO:0046872; GO:0048037; GO:0070062 0 0 0 PF16114;PF00285;PF02629;PF00549; Q9BSV6 CHOYP_MCM3.1.1 m.14854 sp SEN34_HUMAN 36.601 306 167 4 12 290 4 309 6.45E-59 193 SEN34_HUMAN reviewed tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34) TSEN34 LENG5 SEN34 Homo sapiens (Human) 310 "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]; tRNA-type intron splice site recognition and cleavage [GO:0000379]" GO:0000213; GO:0000214; GO:0000379; GO:0003676; GO:0005634; GO:0005654; GO:0005730; GO:0006388; GO:0006397; GO:0016829 0 0 0 PF01974; Q9JJL4 CHOYP_CDC42.2.11 m.18078 sp RHOQ_RAT 37.226 137 75 2 21 147 53 188 6.45E-29 108 RHOQ_RAT reviewed Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) Rhoq Tc10 Rattus norvegicus (Rat) 205 cortical actin cytoskeleton organization [GO:0030866]; GTP metabolic process [GO:0046039]; insulin receptor signaling pathway [GO:0008286]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of glucose import [GO:0046326]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell shape [GO:0008360]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005737; GO:0005884; GO:0005886; GO:0007264; GO:0008286; GO:0008360; GO:0030866; GO:0045121; GO:0045944; GO:0046039; GO:0046326; GO:0051491; GO:0070062; GO:0090005 0 0 0 PF00071; Q9TT38 CHOYP_PA24A.3.3 m.30374 sp PA24A_RABIT 53.435 262 115 3 52 307 461 721 6.45E-88 281 PA24A_RABIT reviewed Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)] PLA2G4A CPLA2 PLA2G4 Oryctolagus cuniculus (Rabbit) 748 phospholipid catabolic process [GO:0009395] GO:0004622; GO:0004623; GO:0005509; GO:0005544; GO:0009395; GO:0016023 0 0 0 PF00168;PF01735; Q9UBF6 CHOYP_ISCW_ISCW016510.3.5 m.37935 sp RBX2_HUMAN 90.805 87 8 0 20 106 27 113 6.45E-54 166 RBX2_HUMAN reviewed RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) RNF7 RBX2 ROC2 SAG Homo sapiens (Human) 113 protein neddylation [GO:0045116]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to redox state [GO:0051775]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005507; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0019788; GO:0031146; GO:0031462; GO:0031463; GO:0031466; GO:0031467; GO:0042787; GO:0043224; GO:0045116; GO:0051775; GO:0061630; GO:0080008; GO:0097602 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12678; Q9UBF6 CHOYP_ISCW_ISCW016510.4.5 m.46841 sp RBX2_HUMAN 90.805 87 8 0 20 106 27 113 6.45E-54 166 RBX2_HUMAN reviewed RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) RNF7 RBX2 ROC2 SAG Homo sapiens (Human) 113 protein neddylation [GO:0045116]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to redox state [GO:0051775]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005507; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0019788; GO:0031146; GO:0031462; GO:0031463; GO:0031466; GO:0031467; GO:0042787; GO:0043224; GO:0045116; GO:0051775; GO:0061630; GO:0080008; GO:0097602 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12678; Q9UBF6 CHOYP_ISCW_ISCW016510.5.5 m.61387 sp RBX2_HUMAN 90.805 87 8 0 20 106 27 113 6.45E-54 166 RBX2_HUMAN reviewed RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein) RNF7 RBX2 ROC2 SAG Homo sapiens (Human) 113 protein neddylation [GO:0045116]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to redox state [GO:0051775]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005507; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0019788; GO:0031146; GO:0031462; GO:0031463; GO:0031466; GO:0031467; GO:0042787; GO:0043224; GO:0045116; GO:0051775; GO:0061630; GO:0080008; GO:0097602 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12678; Q9UHR5 CHOYP_S30BP.1.1 m.62845 sp S30BP_HUMAN 49.333 225 85 5 127 325 84 305 6.45E-63 204 S30BP_HUMAN reviewed SAP30-binding protein (Transcriptional regulator protein HCNGP) SAP30BP HCNGP HTRG HTRP Homo sapiens (Human) 308 "apoptotic process [GO:0006915]; positive regulation of cell death [GO:0010942]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0006915; GO:0010942; GO:0045111 0 0 0 PF07818; A6NIV6 CHOYP_NEMVEDRAFT_V1G241970.1.1 m.19048 sp LRIQ4_HUMAN 29.457 129 91 0 90 218 387 515 6.46E-13 72.4 LRIQ4_HUMAN reviewed Leucine-rich repeat and IQ domain-containing protein 4 (Leucine-rich repeat-containing protein 64) LRRIQ4 LRRC64 Homo sapiens (Human) 560 0 0 0 0 0 PF12799;PF13855; O75382 CHOYP_TRIM3.11.58 m.16306 sp TRIM3_HUMAN 28.283 297 186 8 737 1016 458 744 6.46E-26 118 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0C8E4 CHOYP_M3K7.1.4 m.7880 sp M3K7_RAT 58.482 448 145 10 11 446 29 447 6.46E-174 512 M3K7_RAT reviewed Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) Map3k7 Rattus norvegicus (Rat) 606 "activation of MAPKK activity [GO:0000186]; apoptotic process [GO:0006915]; I-kappaB phosphorylation [GO:0007252]; MAPK cascade [GO:0000165]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JUN kinase activity [GO:0043507]; protein phosphorylation [GO:0006468]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000165; GO:0000186; GO:0000287; GO:0004709; GO:0005524; GO:0005622; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0006468; GO:0006915; GO:0007252; GO:0043123; GO:0043507 0 0 0 PF07714; P17972 CHOYP_ISCW_ISCW006705.1.1 m.56284 sp KCNAW_DROME 40.308 454 230 8 13 448 7 437 6.46E-105 329 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; Q2KIK3 CHOYP_LOC100373771.1.1 m.52860 sp SIM14_BOVIN 53.684 95 37 3 14 104 6 97 6.46E-27 98.2 SIM14_BOVIN reviewed Small integral membrane protein 14 SMIM14 Bos taurus (Bovine) 99 0 GO:0005783; GO:0005789; GO:0016021 0 0 0 PF11027; Q5QJ74 CHOYP_TBCEL.2.2 m.26805 sp TBCEL_HUMAN 37.5 392 223 8 3 385 8 386 6.46E-77 248 TBCEL_HUMAN reviewed Tubulin-specific chaperone cofactor E-like protein (EL) (Leucine-rich repeat-containing protein 35) TBCEL LRRC35 Homo sapiens (Human) 424 0 GO:0005737; GO:0005856 0 0 0 PF14560; Q5RBU8 CHOYP_MMEL1.3.3 m.42932 sp ROA2_PONAB 53.125 192 83 1 77 261 16 207 6.46E-67 215 ROA2_PONAB reviewed Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) HNRNPA2B1 HNRPA2B1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 353 "miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; primary miRNA processing [GO:0031053]" GO:0000166; GO:0000398; GO:0003730; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006406; GO:0030529; GO:0031053; GO:0035198; GO:0043047; GO:0070062; GO:1990247; GO:1990428 0 0 0 PF00076; Q6NRW2 CHOYP_SPDLA.1.1 m.19204 sp SPDLB_XENLA 27.146 431 251 12 3 394 52 458 6.46E-20 96.7 SPDLB_XENLA reviewed Protein Spindly-B (Coiled-coil domain-containing protein 99-B) (Spindle apparatus coiled-coil domain-containing protein 1-B) spdl1-b ccdc99-b Xenopus laevis (African clawed frog) 610 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; mitotic metaphase plate congression [GO:0007080]; protein localization to kinetochore [GO:0034501]; spindle checkpoint [GO:0031577] GO:0000132; GO:0000922; GO:0000940; GO:0005634; GO:0007080; GO:0031577; GO:0034501; GO:0043515; GO:0051301 0 0 0 0 Q6NS45 CHOYP_BRAFLDRAFT_121183.4.8 m.26465 sp CCD66_MOUSE 39.231 130 79 0 740 869 438 567 6.46E-12 73.9 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q86Y13 CHOYP_NEMVEDRAFT_V1G248040.1.1 m.5292 sp DZIP3_HUMAN 28.07 114 68 2 61 160 451 564 6.46E-07 54.3 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q99M80 CHOYP_PTPRT.2.45 m.2969 sp PTPRT_MOUSE 40.076 262 154 2 196 455 900 1160 6.46E-57 207 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ESN6 CHOYP_BRAFLDRAFT_255103.12.18 m.48238 sp TRIM2_MOUSE 25.373 201 126 7 166 352 554 744 6.46E-07 54.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ULJ7 CHOYP_LOC753709.16.44 m.29100 sp ANR50_HUMAN 32.137 585 341 21 1 564 564 1113 6.46E-56 207 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9VZW5 CHOYP_CRE_21950.1.1 m.55 sp FMAR_DROME 28.618 304 178 10 60 346 122 403 6.46E-24 107 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; Q9W725 CHOYP_UCP2.2.3 m.2639 sp UCP2_CYPCA 50.943 212 77 7 22 214 10 213 6.46E-56 183 UCP2_CYPCA reviewed Mitochondrial uncoupling protein 2 (UCP 2) (Solute carrier family 25 member 8) ucp2 slc25a8 Cyprinus carpio (Common carp) 310 mitochondrial transport [GO:0006839] GO:0005743; GO:0006839; GO:0016021 0 0 0 PF00153; A0JNA8 CHOYP_PAXI1.3.4 m.42162 sp PAXI1_BOVIN 39.794 485 281 4 375 855 507 984 6.47E-120 390 PAXI1_BOVIN reviewed PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) PAXIP1 Bos taurus (Bovine) 984 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0016363 0 0 0 PF00533;PF12738;PF16770; P23038 CHOYP_MT.10.18 m.44063 sp MT_CRAVI 55.696 79 29 4 23 99 1 75 6.47E-09 51.6 MT_CRAVI reviewed Metallothionein (MT) 0 Crassostrea virginica (Eastern oyster) 75 0 GO:0046872 0 0 0 0 P49165 CHOYP_RL4.1.6 m.1146 sp RL4_URECA 74.453 137 34 1 1 137 195 330 6.47E-69 218 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; Q5M7R9 CHOYP_ELF1.1.1 m.63294 sp GRHL2_XENTR 43.28 439 219 15 512 932 193 619 6.47E-91 305 GRHL2_XENTR reviewed Grainyhead-like protein 2 homolog (Transcription factor CP2-like 3) grhl2 tfcp2l3 TGas068d14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 619 "bicellular tight junction assembly [GO:0070830]; brain development [GO:0007420]; cell adhesion [GO:0007155]; cell junction assembly [GO:0034329]; epithelial cell morphogenesis [GO:0003382]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0001161; GO:0001843; GO:0003382; GO:0003700; GO:0005634; GO:0005911; GO:0006351; GO:0006357; GO:0007155; GO:0007420; GO:0016020; GO:0021915; GO:0034329; GO:0043565; GO:0045944; GO:0051973; GO:0070830 0 0 0 PF04516; Q6NT55 CHOYP_BRAFLDRAFT_61250.5.14 m.37733 sp CP4FN_HUMAN 43.004 486 253 8 40 513 57 530 6.47E-131 394 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q6ZWX0 CHOYP_ASTER.4.4 m.30483 sp ASTER_MOUSE 82.243 107 16 2 9 113 1 106 6.47E-59 179 ASTER_MOUSE reviewed Protein Asterix (Protein WDR83OS homolog) Wdr83os Mus musculus (Mouse) 106 0 GO:0016021 0 0 0 PF03669; Q80WP8 CHOYP_LOC100555254.1.1 m.40934 sp GADL1_MOUSE 39.13 69 41 1 79 146 72 140 6.47E-09 56.6 GADL1_MOUSE reviewed Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1) Gadl1 Mus musculus (Mouse) 550 carboxylic acid metabolic process [GO:0019752] GO:0004068; GO:0004782; GO:0019752; GO:0030170 0 0 0 PF00282; Q8N0W4 CHOYP_SASB.2.3 m.37538 sp NLGNX_HUMAN 38.983 354 175 10 223 547 41 382 6.47E-67 235 NLGNX_HUMAN reviewed "Neuroligin-4, X-linked (Neuroligin X) (HNLX)" NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 Homo sapiens (Human) 816 adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; learning [GO:0007612]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625] GO:0003360; GO:0004872; GO:0005886; GO:0005887; GO:0007158; GO:0007612; GO:0009986; GO:0014069; GO:0016021; GO:0021549; GO:0030054; GO:0030182; GO:0030425; GO:0030534; GO:0031404; GO:0035176; GO:0035265; GO:0042043; GO:0042803; GO:0045202; GO:0045211; GO:0045216; GO:0050808; GO:0050839; GO:0052689; GO:0060076; GO:0071625; GO:0090394; GO:0097105; GO:0097110 0 0 0 PF00135; Q9FLK4 CHOYP_BRAFLDRAFT_278918.3.5 m.38481 sp GSXL8_ARATH 36.387 393 225 11 4 377 10 396 6.47E-64 216 GSXL8_ARATH reviewed Flavin-containing monooxygenase FMO GS-OX-like 8 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 8) At5g61290 MFB13.9 Arabidopsis thaliana (Mouse-ear cress) 461 oxidation-reduction process [GO:0055114] GO:0004497; GO:0004499; GO:0050660; GO:0050661; GO:0055114 0 0 0 PF00743; Q9MYM7 CHOYP_LOC658348.1.1 m.41613 sp B3GT1_PONPY 31.651 218 144 4 117 334 66 278 6.47E-29 118 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9P267 CHOYP_BRAFLDRAFT_84983.1.1 m.46603 sp MBD5_HUMAN 42.553 141 69 3 313 442 12 151 6.47E-24 114 MBD5_HUMAN reviewed Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5) MBD5 KIAA1461 Homo sapiens (Human) 1494 glucose homeostasis [GO:0042593]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nervous system development [GO:0007399]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of growth hormone receptor signaling pathway [GO:0060399]; regulation of multicellular organism growth [GO:0040014]; single-organism behavior [GO:0044708]; xenophagy [GO:0098792] GO:0002230; GO:0003682; GO:0005634; GO:0007399; GO:0010369; GO:0040014; GO:0042593; GO:0044708; GO:0060399; GO:0070062; GO:0098779; GO:0098792 0 0 0 PF00855; Q9UKK3 CHOYP_LOC100373327.8.13 m.42525 sp PARP4_HUMAN 43.895 647 331 12 23 650 581 1214 6.47E-151 511 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9VE46 CHOYP_BRAFLDRAFT_207989.1.1 m.16773 sp SC5A7_DROME 47.718 482 247 4 3 481 2 481 6.47E-152 451 SC5A7_DROME reviewed High-affinity choline transporter 1 CG7708 Drosophila melanogaster (Fruit fly) 614 acetylcholine biosynthetic process [GO:0008292]; amino acid transmembrane transport [GO:0003333]; choline transport [GO:0015871]; sensory perception of pain [GO:0019233] GO:0003333; GO:0005307; GO:0005887; GO:0008292; GO:0015171; GO:0015220; GO:0015871; GO:0016021; GO:0019233; GO:0033265 0 0 0 PF00474; A2AJ76 CHOYP_LOC658762.2.2 m.53775 sp HMCN2_MOUSE 23.81 315 193 16 337 627 2418 2709 6.48E-12 74.3 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A4IF63 CHOYP_BRAFLDRAFT_87269.8.8 m.60862 sp TRIM2_BOVIN 26.316 228 152 7 332 551 525 744 6.48E-14 78.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_TRIM2.45.59 m.51001 sp TRIM3_HUMAN 29.762 168 88 7 84 242 560 706 6.48E-07 53.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P98187 CHOYP_BRAFLDRAFT_58592.2.2 m.4915 sp CP4F8_HUMAN 50.838 179 86 2 1 178 313 490 6.48E-60 197 CP4F8_HUMAN reviewed Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016021; GO:0018685; GO:0019825; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q08E43 CHOYP_LOC100703270.1.1 m.49140 sp ASB8_BOVIN 48.07 285 141 2 9 290 1 281 6.48E-88 266 ASB8_BOVIN reviewed Ankyrin repeat and SOCS box protein 8 (ASB-8) ASB8 Bos taurus (Bovine) 288 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005737; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q2ABP2 CHOYP_PGAP2.2.3 m.33201 sp PGAP2_CRIGR 40.845 142 71 3 2 133 111 249 6.48E-29 108 PGAP2_CRIGR reviewed Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1) Pgap2 Frag1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 254 GPI anchor biosynthetic process [GO:0006506] GO:0000139; GO:0005789; GO:0006506; GO:0008565; GO:0016021 0 0 0 PF10277; Q5R723 CHOYP_PPIE.1.1 m.18580 sp PPIE_PONAB 72.575 299 80 2 18 315 2 299 6.48E-166 466 PPIE_PONAB reviewed Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Rotamase E) PPIE Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 301 mRNA processing [GO:0006397]; protein folding [GO:0006457]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0003755; GO:0005681; GO:0006397; GO:0006457; GO:0008380 0 0 0 PF00160;PF00076; Q5THR3 CHOYP_LOC100185585.1.1 m.20010 sp EFCB6_HUMAN 34.759 187 116 2 29 215 32 212 6.48E-26 112 EFCB6_HUMAN reviewed EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) 1501 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q8K3K9 CHOYP_AIG1.1.2 m.45751 sp GIMA4_RAT 29.87 154 91 7 21 167 98 241 6.48E-09 57.4 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8MJC3 CHOYP_CASP6.1.1 m.11566 sp CASP3_RABIT 31.679 262 124 13 1 237 44 275 6.48E-23 97.4 CASP3_RABIT reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Oryctolagus cuniculus (Rabbit) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q92847 CHOYP_GHSR.1.1 m.43512 sp GHSR_HUMAN 26.596 282 167 14 1 259 19 283 6.48E-11 67.4 GHSR_HUMAN reviewed Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor) GHSR Homo sapiens (Human) 366 actin polymerization or depolymerization [GO:0008154]; adult feeding behavior [GO:0008343]; cellular response to insulin stimulus [GO:0032869]; decidualization [GO:0046697]; G-protein coupled receptor signaling pathway [GO:0007186]; growth hormone secretion [GO:0030252]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 biosynthetic process [GO:0045409]; negative regulation of tumor necrosis factor biosynthetic process [GO:0042536]; positive regulation of appetite [GO:0032100]; positive regulation of fatty acid metabolic process [GO:0045923]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of multicellular organism growth [GO:0040018]; regulation of hindgut contraction [GO:0043134]; regulation of synapse assembly [GO:0051963]; response to food [GO:0032094]; response to hormone [GO:0009725] GO:0001616; GO:0004930; GO:0005886; GO:0007186; GO:0008154; GO:0008343; GO:0009725; GO:0009755; GO:0009986; GO:0016021; GO:0016520; GO:0017046; GO:0030252; GO:0032094; GO:0032100; GO:0032691; GO:0032869; GO:0040018; GO:0042536; GO:0043005; GO:0043134; GO:0043568; GO:0045121; GO:0045409; GO:0045923; GO:0046676; GO:0046697; GO:0050728; GO:0051963 0 0 0 PF00001; Q9CQZ5 CHOYP_LOC101070737.3.3 m.20342 sp NDUA6_MOUSE 56.25 112 49 0 19 130 20 131 6.48E-42 138 NDUA6_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 (Complex I-B14) (CI-B14) (NADH-ubiquinone oxidoreductase B14 subunit) Ndufa6 Mus musculus (Mouse) 131 oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0005739; GO:0005747; GO:0006979; GO:0031966; GO:0055114 0 0 0 PF05347; Q9NXW9 CHOYP_LOC100367945.1.1 m.6651 sp ALKB4_HUMAN 44.027 293 133 3 1 264 12 302 6.48E-82 251 ALKB4_HUMAN reviewed Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 4) ALKBH4 ABH4 Homo sapiens (Human) 302 "actomyosin structure organization [GO:0031032]; cleavage furrow ingression [GO:0036090]; protein demethylation [GO:0006482]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003779; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006482; GO:0016706; GO:0030496; GO:0031032; GO:0032451; GO:0036090; GO:0046872; GO:0070938 0 0 0 0 Q9VCA2 CHOYP_S22A8.1.1 m.26317 sp ORCT_DROME 26.782 519 343 8 19 505 4 517 6.48E-58 204 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9ZRW8 CHOYP_GSTUL.1.1 m.35986 sp GSTUJ_ARATH 33.5 200 127 5 14 212 11 205 6.48E-23 95.5 GSTUJ_ARATH reviewed Glutathione S-transferase U19 (AtGSTU19) (EC 2.5.1.18) (GST class-tau member 19) (Glutathione S-transferase 8) GSTU19 GST8 At1g78380 F3F9.11 Arabidopsis thaliana (Mouse-ear cress) 219 cellular response to water deprivation [GO:0042631]; glutathione metabolic process [GO:0006749]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]; toxin catabolic process [GO:0009407] GO:0004364; GO:0004601; GO:0005737; GO:0005774; GO:0005829; GO:0005886; GO:0006749; GO:0006979; GO:0009407; GO:0009507; GO:0009570; GO:0042631; GO:0043295; GO:0046686 0 0 0 PF02798; F1MNN4 CHOYP_LOC100377670.2.2 m.29516 sp FBXW7_BOVIN 31.25 112 60 4 427 531 473 574 6.49E-06 52.8 FBXW7_BOVIN reviewed F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) FBXW7 FBW7 Bos taurus (Bovine) 627 cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; negative regulation of DNA endoreduplication [GO:0032876]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of mitophagy [GO:1903146]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062] GO:0005654; GO:0005730; GO:0005737; GO:0006974; GO:0007062; GO:0016567; GO:0019005; GO:0031146; GO:0032876; GO:0034644; GO:0045741; GO:0050816; GO:0050821; GO:0051443; GO:0070374; GO:0097027; GO:1901800; GO:1903146; GO:1903378; GO:1903955; GO:1990452; GO:2000060 0 0 0 PF12937;PF00400; O95235 CHOYP_LOC100368346.2.2 m.25417 sp KI20A_HUMAN 37.731 811 407 24 22 790 35 789 6.49E-143 451 KI20A_HUMAN reviewed Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6) KIF20A MKLP2 RAB6KIFL Homo sapiens (Human) 890 cell separation after cytokinesis [GO:0000920]; cytokinesis [GO:0000910]; microtubule-based movement [GO:0007018]; microtubule bundle formation [GO:0001578]; mitotic cytokinesis [GO:0000281]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0000281; GO:0000910; GO:0000920; GO:0001578; GO:0003777; GO:0005215; GO:0005524; GO:0005654; GO:0005794; GO:0005819; GO:0005871; GO:0005874; GO:0007018; GO:0015031; GO:0016192; GO:0016887; GO:0019901; GO:0030496 0 0 0 PF00225; P15771 CHOYP_CALM.31.50 m.48471 sp NUCL_CHICK 40.678 59 33 1 1 57 489 547 6.49E-07 50.4 NUCL_CHICK reviewed Nucleolin (Protein C23) NCL Gallus gallus (Chicken) 694 0 GO:0000166; GO:0003677; GO:0003723; GO:0005730 0 0 0 PF00076; Q1WIM2 CHOYP_LRIG3.3.3 m.41029 sp CADM2_RAT 24.116 311 187 13 26 328 31 300 6.49E-11 67.8 CADM2_RAT reviewed Cell adhesion molecule 2 (Immunoglobulin superfamily member 4D) (IgSF4D) (Nectin-like protein 3) (NECL-3) (Synaptic cell adhesion molecule 2) (SynCAM 2) Cadm2 Igsf4d Necl3 Rattus norvegicus (Rat) 435 brain development [GO:0007420]; cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0004872; GO:0005102; GO:0005737; GO:0005887; GO:0005913; GO:0007156; GO:0007157; GO:0007420; GO:0008037; GO:0030424; GO:0032809; GO:0042803; GO:0045202; GO:0050839 0 0 0 PF08205;PF07686; Q25145 CHOYP_TPM.14.19 m.41137 sp TPM_HALRU 77.821 257 57 0 1 257 1 257 6.49E-126 363 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q2IBC5 CHOYP_LOC100113488.1.1 m.15322 sp CAV2_RAT 32.773 119 79 1 9 127 35 152 6.49E-17 77.8 CAV2_RAT reviewed Caveolin-2 Cav2 Rattus norvegicus (Rat) 162 caveola assembly [GO:0070836]; chemical synaptic transmission [GO:0007268]; endoplasmic reticulum organization [GO:0007029]; insulin receptor signaling pathway [GO:0008286]; mitochondrion organization [GO:0007005]; negative regulation of endothelial cell proliferation [GO:0001937]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to nucleus [GO:1900182]; skeletal muscle fiber development [GO:0048741]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000139; GO:0000149; GO:0001937; GO:0005635; GO:0005637; GO:0005737; GO:0005783; GO:0005794; GO:0005811; GO:0005829; GO:0005886; GO:0005901; GO:0006906; GO:0007005; GO:0007029; GO:0007268; GO:0008286; GO:0009986; GO:0019905; GO:0031234; GO:0031435; GO:0031748; GO:0043234; GO:0043410; GO:0045121; GO:0048278; GO:0048471; GO:0048741; GO:0050731; GO:0051219; GO:0060161; GO:0070836; GO:1900182 0 0 0 PF01146; Q5RJQ0 CHOYP_CHST1.3.3 m.41514 sp CHST1_RAT 28.704 324 164 15 96 372 57 360 6.49E-16 82 CHST1_RAT reviewed Carbohydrate sulfotransferase 1 (EC 2.8.2.21) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1) (GST-1) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) Chst1 Rattus norvegicus (Rat) 411 galactose metabolic process [GO:0006012]; inflammatory response [GO:0006954]; keratan sulfate metabolic process [GO:0042339]; sulfur compound metabolic process [GO:0006790] GO:0000139; GO:0001517; GO:0006012; GO:0006790; GO:0006954; GO:0016021; GO:0042339; GO:0045130 0 0 0 PF00685; Q5ZLG9 CHOYP_WDR59.2.5 m.37914 sp WDR59_CHICK 36.86 605 332 15 5 586 360 937 6.49E-109 354 WDR59_CHICK reviewed WD repeat-containing protein 59 WDR59 RCJMB04_6d21 Gallus gallus (Chicken) 973 cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008] GO:0032008; GO:0034198; GO:0061700 0 0 0 PF00400; Q63HN8 CHOYP_BRAFLDRAFT_106560.9.14 m.35081 sp RN213_HUMAN 27.497 1582 914 54 367 1774 1840 3362 6.49E-125 442 RN213_HUMAN reviewed E3 ubiquitin-protein ligase RNF213 (EC 3.6.4.-) (EC 6.3.2.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) RNF213 ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR Homo sapiens (Human) 5207 angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0001525; GO:0002040; GO:0004842; GO:0005730; GO:0005737; GO:0005829; GO:0006511; GO:0008270; GO:0016020; GO:0016567; GO:0016874; GO:0016887; GO:0051260; GO:0051865; GO:2000051 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:21799892}. 0 0 PF00097; Q6NV34 CHOYP_DECR2.1.2 m.29687 sp DECR2_DANRE 59.233 287 111 2 22 302 3 289 6.49E-121 352 DECR2_DANRE reviewed "Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2)" decr2 si:ch211-153c20.5 zgc:85626 Danio rerio (Zebrafish) (Brachydanio rerio) 300 fatty acid metabolic process [GO:0006631] GO:0005777; GO:0006631; GO:0008670 0 0 0 0 Q8BZ25 CHOYP_LOC590657.1.1 m.633 sp ANKK1_MOUSE 32.27 282 179 6 5 281 24 298 6.49E-34 142 ANKK1_MOUSE reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) Ankk1 Mus musculus (Mouse) 745 0 GO:0004674; GO:0005524 0 0 0 PF00023;PF12796;PF07714; Q8BZM1 CHOYP_GLMN.1.1 m.17085 sp GLMN_MOUSE 29.719 498 297 10 119 609 131 582 6.49E-55 199 GLMN_MOUSE reviewed Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein) Glmn Fap48 Mus musculus (Mouse) 596 "cell surface receptor signaling pathway [GO:0007166]; circulatory system development [GO:0072359]; muscle cell differentiation [GO:0042692]; negative regulation of cell proliferation [GO:0008285]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of interleukin-2 biosynthetic process [GO:0045086]; positive regulation of phosphorylation [GO:0042327]; regulation of gene expression, epigenetic [GO:0040029]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570]" GO:0001570; GO:0001843; GO:0005102; GO:0005171; GO:0005737; GO:0007166; GO:0008285; GO:0031461; GO:0031462; GO:0031463; GO:0031464; GO:0031625; GO:0032434; GO:0040029; GO:0042130; GO:0042327; GO:0042692; GO:0045086; GO:0050715; GO:0055105; GO:0072359 0 0 0 PF08568; Q91WD4 CHOYP_CG025.1.1 m.35315 sp CG025_MOUSE 41.86 473 203 10 16 480 5 413 6.49E-112 342 CG025_MOUSE reviewed UPF0415 protein C7orf25 homolog 0 Mus musculus (Mouse) 421 0 0 0 0 0 PF07000; Q96M20 CHOYP_LOC100893228.1.5 m.6775 sp CNBD2_HUMAN 30.435 230 147 5 88 311 72 294 6.49E-21 100 CNBD2_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 2 CNBD2 C20orf152 Homo sapiens (Human) 576 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; Q9XWD6 CHOYP_MEG10.35.91 m.38928 sp CED1_CAEEL 37.566 189 109 5 28 214 354 535 6.49E-25 105 CED1_CAEEL reviewed Cell death abnormality protein 1 ced-1 Y47H9C.4 Caenorhabditis elegans 1111 actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; defense response to bacterium [GO:0042742]; engulfment of apoptotic cell [GO:0043652]; establishment of protein localization [GO:0045184]; phagolysosome assembly [GO:0001845]; programmed cell death [GO:0012501]; recognition of apoptotic cell [GO:0043654] GO:0001845; GO:0001891; GO:0005044; GO:0005886; GO:0006915; GO:0009986; GO:0012501; GO:0016021; GO:0030670; GO:0031260; GO:0031532; GO:0034620; GO:0042742; GO:0043652; GO:0043654; GO:0045184 0 0 0 PF00053; A1A4K8 CHOYP_BRAFLDRAFT_202693.2.4 m.14394 sp U2AF1_BOVIN 94.318 88 5 0 1 88 99 186 6.50E-57 182 U2AF1_BOVIN reviewed Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit) U2AF1 Bos taurus (Bovine) 237 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]" GO:0000166; GO:0000398; GO:0016607; GO:0044822; GO:0046872; GO:0071013; GO:0089701; GO:1903146; GO:1903955 0 0 0 PF00076;PF00642; A6H7B8 CHOYP_PGAP2.1.3 m.11359 sp PGAP2_BOVIN 46.371 248 128 2 1 248 8 250 6.50E-76 233 PGAP2_BOVIN reviewed Post-GPI attachment to proteins factor 2 PGAP2 Bos taurus (Bovine) 254 GPI anchor biosynthetic process [GO:0006506]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; signal transduction in response to DNA damage [GO:0042770] GO:0000139; GO:0005634; GO:0005789; GO:0006506; GO:0008565; GO:0016021; GO:0042770; GO:0042771; GO:1902230 0 0 0 PF10277; A6QQY2 CHOYP_NS1BP.2.2 m.8101 sp KLH13_BOVIN 29.496 139 88 2 80 218 388 516 6.50E-13 70.5 KLH13_BOVIN reviewed Kelch-like protein 13 KLHL13 Bos taurus (Bovine) 655 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; B4F7A7 CHOYP_LOC100373990.1.1 m.6259 sp CEP57_RAT 39.706 476 255 8 77 538 41 498 6.50E-88 282 CEP57_RAT reviewed Centrosomal protein of 57 kDa (Cep57) (Translokin) Cep57 Rattus norvegicus (Rat) 499 "fibroblast growth factor receptor signaling pathway [GO:0008543]; microtubule anchoring [GO:0034453]; mitotic sister chromatid segregation [GO:0000070]; protein homooligomerization [GO:0051260]; protein import into nucleus, translocation [GO:0000060]; spermatid development [GO:0007286]" GO:0000060; GO:0000070; GO:0005654; GO:0005794; GO:0005813; GO:0005874; GO:0007286; GO:0008017; GO:0008543; GO:0034453; GO:0051260 0 0 0 PF14073;PF06657; O01761 CHOYP_ISCW_ISCW023694.2.2 m.31649 sp UNC89_CAEEL 25.053 471 285 20 180 616 4462 4898 6.50E-08 62.4 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O45782 CHOYP_LOC100176335.5.7 m.48030 sp ARD17_CAEEL 30.7 443 236 13 1 391 1 424 6.50E-59 200 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; P08575 CHOYP_LOC100208023.2.8 m.33918 sp PTPRC_HUMAN 38.567 293 167 8 21 303 664 953 6.50E-54 194 PTPRC_HUMAN reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) PTPRC CD45 Homo sapiens (Human) 1304 B cell proliferation [GO:0042100]; B cell receptor signaling pathway [GO:0050853]; bone marrow development [GO:0048539]; cell cycle phase transition [GO:0044770]; cell surface receptor signaling pathway [GO:0007166]; defense response to virus [GO:0051607]; dephosphorylation [GO:0016311]; hematopoietic progenitor cell differentiation [GO:0002244]; immunoglobulin biosynthetic process [GO:0002378]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cytokine-mediated signaling pathway [GO:0001960]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of antigen receptor-mediated signaling pathway [GO:0050857]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of hematopoietic stem cell migration [GO:2000473]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of T cell proliferation [GO:0042102]; protein dephosphorylation [GO:0006470]; regulation of cell cycle [GO:0051726]; release of sequestered calcium ion into cytosol [GO:0051209]; stem cell development [GO:0048864]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852] GO:0001915; GO:0001960; GO:0002244; GO:0002378; GO:0004725; GO:0005001; GO:0005886; GO:0005887; GO:0005925; GO:0006469; GO:0006470; GO:0006933; GO:0007166; GO:0009897; GO:0009986; GO:0016020; GO:0016311; GO:0019901; GO:0030217; GO:0030890; GO:0042100; GO:0042102; GO:0044770; GO:0045121; GO:0045860; GO:0048539; GO:0048864; GO:0050852; GO:0050853; GO:0050857; GO:0051209; GO:0051607; GO:0051726; GO:0070062; GO:2000473; GO:2000648 0 0 0 PF12567;PF00041;PF12453;PF00102; P79781 CHOYP_LOC100372815.3.3 m.63898 sp RS27A_CHICK 93.443 122 8 0 16 137 35 156 6.50E-70 210 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; P82596 CHOYP_LECM3.1.1 m.2458 sp PLC_HALLA 31.655 139 86 4 25 162 2 132 6.50E-20 84.3 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; P98203 CHOYP_LOC100167447.1.1 m.66505 sp ARVC_MOUSE 39.609 563 285 16 281 820 343 873 6.50E-108 360 ARVC_MOUSE reviewed Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog Arvcf Mus musculus (Mouse) 962 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; multicellular organism development [GO:0007275]; single organismal cell-cell adhesion [GO:0016337] GO:0005634; GO:0005737; GO:0005886; GO:0007275; GO:0016337; GO:0016339 0 0 0 PF00514; Q13263 CHOYP_TIF1B.1.10 m.3757 sp TIF1B_HUMAN 36.283 113 67 3 1 109 135 246 6.50E-11 61.6 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q3S4T7 CHOYP_GRP78.4.5 m.39130 sp GRP78_ICTTR 75.54 278 67 1 38 314 30 307 6.50E-146 448 GRP78_ICTTR reviewed 78 kDa glucose-regulated protein (GRP-78) (Heat shock 70 kDa protein 5) HSPA5 GRP78 Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) 654 maintenance of protein localization in endoplasmic reticulum [GO:0035437]; positive regulation of cell migration [GO:0030335] GO:0005524; GO:0005788; GO:0030335; GO:0035437; GO:0042470 0 0 0 PF00012; Q6PFY8 CHOYP_LOC100376215.11.19 m.35421 sp TRI45_MOUSE 22.764 246 165 9 2 232 125 360 6.50E-06 50.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q96AE7 CHOYP_PHUM_PHUM170150.1.1 m.24960 sp TTC17_HUMAN 24.084 191 132 4 104 284 954 1141 6.50E-12 70.5 TTC17_HUMAN reviewed Tetratricopeptide repeat protein 17 (TPR repeat protein 17) TTC17 Homo sapiens (Human) 1141 actin filament polymerization [GO:0030041]; cilium organization [GO:0044782] GO:0005737; GO:0005886; GO:0015629; GO:0030041; GO:0044782 0 0 0 PF13181; Q96RW7 CHOYP_PGBM.3.3 m.55206 sp HMCN1_HUMAN 25.128 1369 793 64 122 1411 791 2006 6.50E-66 252 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9Y5Q5 CHOYP_ND5.4.6 m.42737 sp CORIN_HUMAN 28.067 595 363 16 883 1427 455 1034 6.50E-59 226 CORIN_HUMAN reviewed "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) 1042 female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] GO:0003050; GO:0004252; GO:0005576; GO:0005886; GO:0005887; GO:0007565; GO:0008217; GO:0009986; GO:0016021; GO:0016486; GO:0035813; GO:1903779 0 0 cd00190; PF01392;PF00057;PF15494;PF00089; O94985 CHOYP_CLSTN1.1.1 m.55323 sp CSTN1_HUMAN 35.408 932 495 24 42 921 40 916 6.51E-173 533 CSTN1_HUMAN reviewed Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)] CLSTN1 CS1 KIAA0911 Homo sapiens (Human) 981 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission [GO:0050806]; regulation of cell growth [GO:0001558] GO:0000139; GO:0001540; GO:0001558; GO:0005509; GO:0005634; GO:0005789; GO:0007155; GO:0007156; GO:0009986; GO:0016021; GO:0019894; GO:0030054; GO:0042988; GO:0042995; GO:0045211; GO:0050806; GO:0051965; GO:0070062 0 0 0 PF00028; P37837 CHOYP_TALDO.2.2 m.43331 sp TALDO_HUMAN 67.988 328 103 1 4 329 3 330 6.51E-166 468 TALDO_HUMAN reviewed Transaldolase (EC 2.2.1.2) TALDO1 TAL TALDO TALDOR Homo sapiens (Human) 337 "carbohydrate metabolic process [GO:0005975]; fructose 6-phosphate metabolic process [GO:0006002]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; xylulose biosynthetic process [GO:0005999]" GO:0004801; GO:0005634; GO:0005737; GO:0005829; GO:0005975; GO:0005999; GO:0006002; GO:0006098; GO:0009052; GO:0048029; GO:0070062 PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. 0 0 PF00923; P62909 CHOYP_RS3.2.7 m.23037 sp RS3_RAT 90.254 236 22 1 16 251 1 235 6.51E-156 436 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; Q2VPU4 CHOYP_MLXIP.3.3 m.27495 sp MLXIP_MOUSE 39.906 213 124 2 48 260 695 903 6.51E-36 144 MLXIP_MOUSE reviewed MLX-interacting protein (Transcriptional activator MondoA) Mlxip Mir Mus musculus (Mouse) 917 "nucleocytoplasmic transport [GO:0006913]; regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter [GO:1900402]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000989; GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0005741; GO:0006351; GO:0006357; GO:0006913; GO:1900402 0 0 0 PF00010; Q80W93 CHOYP_LOC100375784.5.6 m.48394 sp HYDIN_MOUSE 57.813 192 70 1 24 215 68 248 6.51E-68 231 HYDIN_MOUSE reviewed Hydrocephalus-inducing protein (Protein Hy-3) Hydin Hy3 Mus musculus (Mouse) 5154 axonemal central apparatus assembly [GO:1904158]; cilium movement [GO:0003341]; epithelial cell development [GO:0002064]; multicellular organism development [GO:0007275]; trachea development [GO:0060438]; ventricular system development [GO:0021591] GO:0002064; GO:0003341; GO:0007275; GO:0021591; GO:0060438; GO:1904158; GO:1990718 0 0 0 PF15780;PF00635; Q8IWZ3 CHOYP_LOC100641396.10.27 m.35161 sp ANKH1_HUMAN 33.081 529 295 19 275 780 205 697 6.51E-53 203 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8WV41 CHOYP_LOC100376668.1.1 m.63418 sp SNX33_HUMAN 43.86 399 221 1 84 482 178 573 6.51E-126 381 SNX33_HUMAN reviewed Sorting nexin-33 (SH3 and PX domain-containing protein 3) SNX33 SH3PX3 SH3PXD3C SNX30 Homo sapiens (Human) 574 cleavage furrow formation [GO:0036089]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; macropinocytosis [GO:0044351]; membrane tubulation [GO:0097320]; mitotic cytokinesis [GO:0000281]; mitotic nuclear division [GO:0007067]; negative regulation of endocytosis [GO:0045806]; negative regulation of protein localization to cell surface [GO:2000009]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of protein localization to cell surface [GO:2000010]; protein import [GO:0017038]; vesicle organization [GO:0016050] GO:0000281; GO:0005768; GO:0005829; GO:0006886; GO:0006897; GO:0007032; GO:0007067; GO:0016020; GO:0016023; GO:0016050; GO:0016197; GO:0017038; GO:0019898; GO:0030659; GO:0035091; GO:0036089; GO:0042802; GO:0044351; GO:0045806; GO:0051044; GO:0097320; GO:2000009; GO:2000010 0 0 0 PF10456;PF00787;PF14604; Q95YM8 CHOYP_MBLK1.1.1 m.51932 sp MBLK1_APIME 43.195 169 61 7 398 538 936 1097 6.51E-23 108 MBLK1_APIME reviewed Mushroom body large-type Kenyon cell-specific protein 1 Mblk-1 Apis mellifera (Honeybee) 1598 "memory [GO:0007613]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0007613; GO:0042803; GO:0043565; GO:0045893 0 0 0 PF05225; Q9R1R2 CHOYP_contig_000794 m.812 sp TRIM3_MOUSE 25.658 152 108 3 1 148 593 743 6.51E-06 52 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; B2IZD3 CHOYP_LOC100493088.4.4 m.61884 sp BDLP_NOSP7 21.739 299 200 7 31 308 16 301 6.52E-13 73.2 BDLP_NOSP7 reviewed Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5) Npun_R6513 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 693 0 GO:0003924; GO:0005525; GO:0005886; GO:0008289; GO:0016021 0 0 0 PF00350; O61463 CHOYP_RLA2.2.9 m.14454 sp RLA2_CRYST 65.672 67 23 0 3 69 1 67 6.52E-25 95.5 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 P15989 CHOYP_CO6A3.2.5 m.39533 sp CO6A3_CHICK 22.918 1789 1153 62 27 1768 228 1837 6.52E-86 317 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P16157 CHOYP_TVAG_168010.21.45 m.42963 sp ANK1_HUMAN 34.004 497 304 5 40 535 82 555 6.52E-73 256 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P59222 CHOYP_BRAFLDRAFT_235412.1.2 m.52493 sp SREC2_MOUSE 28.272 191 103 8 180 340 164 350 6.52E-09 62 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P79098 CHOYP_APN.2.3 m.10044 sp AMPN_BOVIN 37.171 608 351 12 2 584 363 964 6.52E-125 394 AMPN_BOVIN reviewed Aminopeptidase N (AP-N) (bAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (CD antigen CD13) ANPEP APN Bos taurus (Bovine) 965 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0001618; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0016021; GO:0030154; GO:0042277; GO:0043171; GO:0070006 0 0 0 PF11838;PF01433; Q04281 CHOYP_BRAFLDRAFT_278777.1.1 m.1970 sp HOX71_XENLA 53.182 220 80 6 62 275 63 265 6.52E-57 188 HOX71_XENLA reviewed Homeobox protein XHOX-7.1 (Fragment) 0 Xenopus laevis (African clawed frog) 295 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; Q04757 CHOYP_CG14207.1.1 m.41524 sp HR29_HALRO 36.082 97 57 2 35 126 156 252 6.52E-15 71.6 HR29_HALRO reviewed Body wall muscle protein HR-29 0 Halocynthia roretzi (Sea squirt) (Cynthia roretzi) 252 0 GO:0016020 0 0 0 PF00011; Q26636 CHOYP_LOC659226.3.3 m.66773 sp CATL_SARPE 62.416 149 56 0 1 149 191 339 6.52E-67 209 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q3TLR7 CHOYP_TCPD.1.1 m.13555 sp DTL_MOUSE 45.729 398 208 5 79 468 18 415 6.52E-115 367 DTL_MOUSE reviewed Denticleless protein homolog (Lethal(2) denticleless protein homolog) (Meth A retinoic acid-regulated nuclear matrix-associated protein) (Meth A RAMP) (Retinoic acid-regulated nuclear matrix-associated protein) Dtl Cdt2 L2dtl Ramp Mus musculus (Mouse) 729 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; G2 DNA damage checkpoint [GO:0031572]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006260; GO:0006511; GO:0006513; GO:0006974; GO:0009411; GO:0019985; GO:0031464; GO:0031465; GO:0031572; GO:0031965; GO:0043231; GO:0051726 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q4R7E2 CHOYP_PHUM_PHUM003160.1.1 m.18892 sp ZDH16_MACFA 42.571 350 163 4 31 377 47 361 6.52E-87 271 ZDH16_MACFA reviewed Probable palmitoyltransferase ZDHHC16 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 16) (DHHC-16) ZDHHC16 QtsA-15522 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 377 apoptotic process [GO:0006915] GO:0005789; GO:0006915; GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q6UX65 CHOYP_AAEL_AAEL008408.1.1 m.15410 sp DRAM2_HUMAN 30.12 249 165 4 73 321 3 242 6.52E-28 113 DRAM2_HUMAN reviewed DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) DRAM2 TMEM77 PSEC0031 UNQ154/PRO180 Homo sapiens (Human) 266 apoptotic process [GO:0006915]; autophagy [GO:0006914]; photoreceptor cell maintenance [GO:0045494]; regulation of autophagy [GO:0010506]; visual perception [GO:0007601] GO:0001917; GO:0005737; GO:0005764; GO:0005765; GO:0005794; GO:0006914; GO:0006915; GO:0007601; GO:0010506; GO:0016021; GO:0016324; GO:0043231; GO:0045494 0 0 0 PF10277; Q8C4U2 CHOYP_LOC100119552.1.1 m.62984 sp TM145_MOUSE 23.569 297 197 8 174 462 144 418 6.52E-11 68.9 TM145_MOUSE reviewed Transmembrane protein 145 Tmem145 Mus musculus (Mouse) 746 G-protein coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] GO:0007186; GO:0016021; GO:0019236 0 0 0 PF10192; Q8N2E2 CHOYP_VWDE.8.13 m.38774 sp VWDE_HUMAN 24.427 655 384 31 9 603 12 615 6.52E-24 113 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TDY8 CHOYP_BRAFLDRAFT_126585.1.1 m.51974 sp IGDC4_HUMAN 24.335 263 172 10 209 459 419 666 6.52E-06 53.1 IGDC4_HUMAN reviewed Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36) IGDCC4 DDM36 KIAA1628 NOPE Homo sapiens (Human) 1250 0 GO:0005886; GO:0016021 0 0 0 PF00041;PF07679; Q96MM6 CHOYP_BRAFLDRAFT_208436.2.32 m.15127 sp HS12B_HUMAN 37.337 383 183 10 1 333 65 440 6.52E-73 241 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96SN8 CHOYP_TVAG_268110.2.13 m.2585 sp CK5P2_HUMAN 34.058 276 136 7 32 265 35 306 6.52E-28 128 CK5P2_HUMAN reviewed CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) CDK5RAP2 CEP215 KIAA1633 Homo sapiens (Human) 1893 "brain development [GO:0007420]; centriole replication [GO:0007099]; centrosome organization [GO:0051297]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule bundle formation [GO:0001578]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; negative regulation of centriole replication [GO:0046600]; negative regulation of neuron differentiation [GO:0045665]; neurogenesis [GO:0022008]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of neuron differentiation [GO:0045664]; regulation of spindle checkpoint [GO:0090231]" GO:0000086; GO:0000132; GO:0000226; GO:0000242; GO:0000922; GO:0001578; GO:0005516; GO:0005737; GO:0005794; GO:0005813; GO:0005829; GO:0005856; GO:0005874; GO:0007059; GO:0007099; GO:0007420; GO:0008017; GO:0015631; GO:0019901; GO:0022008; GO:0030054; GO:0031023; GO:0035371; GO:0044212; GO:0045664; GO:0045665; GO:0045893; GO:0046600; GO:0048471; GO:0051297; GO:0070062; GO:0090231; GO:0097431 0 0 0 PF07989; Q9VR07 CHOYP_LOC754651.1.1 m.5042 sp INE_DROME 27.295 403 234 13 2 363 328 712 6.52E-34 140 INE_DROME reviewed Sodium- and chloride-dependent GABA transporter ine (Protein inebriated) (Protein receptor oscillation A) ine rosA CG15444 Drosophila melanogaster (Fruit fly) 943 glial cell growth [GO:0042065]; multicellular organismal water homeostasis [GO:0050891]; neurotransmitter transport [GO:0006836]; perineurial glial growth [GO:0042066]; regulation of response to osmotic stress [GO:0047484]; response to water deprivation [GO:0009414]; transmission of nerve impulse [GO:0019226]; transport [GO:0006810] GO:0005034; GO:0005215; GO:0005328; GO:0005886; GO:0005887; GO:0006810; GO:0006836; GO:0009414; GO:0009881; GO:0016021; GO:0016323; GO:0019226; GO:0042065; GO:0042066; GO:0047484; GO:0050891 0 0 0 PF00209; Q9Y5Q9 CHOYP_TF3C3.1.3 m.6281 sp TF3C3_HUMAN 52.128 188 87 1 209 396 133 317 6.52E-59 209 TF3C3_HUMAN reviewed General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma) GTF3C3 Homo sapiens (Human) 886 "5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase III promoter [GO:0006383]; tRNA transcription from RNA polymerase III promoter [GO:0042797]" GO:0000127; GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006383; GO:0031965; GO:0042791; GO:0042797 0 0 0 PF13181; Q9Y6R7 CHOYP_BRAFLDRAFT_66592.1.1 m.64874 sp FCGBP_HUMAN 24.524 420 290 13 99 514 35 431 6.52E-18 91.7 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A2ASS6 CHOYP_LOC100375089.1.1 m.1342 sp TITIN_MOUSE 31.034 116 74 3 16 129 29445 29556 6.53E-10 59.3 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; A4IF63 CHOYP_TRIM2.13.59 m.25214 sp TRIM2_BOVIN 26.316 228 132 10 92 307 540 743 6.53E-09 60.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B2RU80 CHOYP_LOC100902565.1.1 m.19044 sp PTPRB_MOUSE 31.915 705 407 22 15 684 1320 1986 6.53E-86 300 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; E9PYL2 CHOYP_LOC100121198.1.1 m.56105 sp PRR12_MOUSE 26.943 193 131 3 1134 1326 1845 2027 6.53E-19 97.4 PRR12_MOUSE reviewed Proline-rich protein 12 Prr12 Kiaa1205 Mus musculus (Mouse) 2035 0 GO:0003677 0 0 0 PF13926; O17320 CHOYP_ACT.25.27 m.63943 sp ACT_CRAGI 84.337 166 20 1 1 166 1 160 6.53E-98 290 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O60462 CHOYP_contig_044964 m.52177 sp NRP2_HUMAN 27.545 167 97 9 56 215 45 194 6.53E-07 53.1 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P49013 CHOYP_LOC100634060.28.37 m.62014 sp FBP3_STRPU 48.969 194 99 0 1 194 212 405 6.53E-60 199 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P49281 CHOYP_NRAM2.1.1 m.32159 sp NRAM2_HUMAN 65.649 131 45 0 1 131 372 502 6.53E-52 176 NRAM2_HUMAN reviewed Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) SLC11A2 DCT1 DMT1 NRAMP2 OK/SW-cl.20 Homo sapiens (Human) 568 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cadmium ion transmembrane transport [GO:0070574]; cellular iron ion homeostasis [GO:0006879]; cellular response to oxidative stress [GO:0034599]; cobalt ion transport [GO:0006824]; copper ion transport [GO:0006825]; dendrite morphogenesis [GO:0048813]; detection of oxygen [GO:0003032]; erythrocyte development [GO:0048821]; ferrous iron import [GO:0070627]; ferrous iron transport [GO:0015684]; heme biosynthetic process [GO:0006783]; lead ion transport [GO:0015692]; learning or memory [GO:0007611]; manganese ion transport [GO:0006828]; multicellular organismal iron ion homeostasis [GO:0060586]; nickel cation transport [GO:0015675]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; transferrin transport [GO:0033572]; vanadium ion transport [GO:0015676] GO:0001666; GO:0003032; GO:0005375; GO:0005381; GO:0005384; GO:0005385; GO:0005634; GO:0005737; GO:0005741; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005773; GO:0005802; GO:0005886; GO:0005887; GO:0006783; GO:0006824; GO:0006825; GO:0006828; GO:0006879; GO:0006919; GO:0007611; GO:0009986; GO:0010039; GO:0015078; GO:0015086; GO:0015087; GO:0015093; GO:0015094; GO:0015099; GO:0015100; GO:0015295; GO:0015639; GO:0015675; GO:0015676; GO:0015684; GO:0015692; GO:0016020; GO:0016324; GO:0022890; GO:0031410; GO:0031526; GO:0031902; GO:0033570; GO:0033572; GO:0034599; GO:0045177; GO:0045178; GO:0046870; GO:0046915; GO:0048471; GO:0048813; GO:0048821; GO:0055037; GO:0060586; GO:0070574; GO:0070627; GO:0070826 0 0 0 PF01566; P53013 CHOYP_EF-1A.9.9 m.63039 sp EF1A_CAEEL 68.182 264 67 4 1 256 208 462 6.53E-117 345 EF1A_CAEEL reviewed Elongation factor 1-alpha (EF-1-alpha) eft-3 F31E3.5; eft-4 R03G5.1 Caenorhabditis elegans 463 embryo development ending in birth or egg hatching [GO:0009792]; growth [GO:0040007] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0008135; GO:0009792; GO:0040007 0 0 0 PF03144;PF03143; Q13639 CHOYP_LOC100679308.1.1 m.27741 sp 5HT4R_HUMAN 21.727 359 234 13 52 377 25 369 6.53E-07 55.1 5HT4R_HUMAN reviewed 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) HTR4 Homo sapiens (Human) 388 "chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid signaling pathway [GO:0007214]; G-protein coupled receptor signaling pathway [GO:0007186]; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; regulation of appetite [GO:0032098]" GO:0004993; GO:0005737; GO:0005768; GO:0005886; GO:0005887; GO:0007186; GO:0007187; GO:0007214; GO:0007268; GO:0016020; GO:0032098 0 0 0 PF00001; Q2PFW9 CHOYP_ISCW_ISCW019027.1.2 m.50688 sp NOVA1_MACFA 59.868 152 54 1 55 199 51 202 6.53E-54 181 NOVA1_MACFA reviewed RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Ventral neuron-specific protein 1) NOVA1 QflA-17531 QtsA-14227 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 483 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0003723; GO:0005634 0 0 0 PF00013; Q3UPW2 CHOYP_LOC100368128.1.1 m.9893 sp ELF3_MOUSE 26.761 355 203 10 108 453 77 383 6.53E-30 123 ELF3_MOUSE reviewed ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) Elf3 Ert Esx Jen Mus musculus (Mouse) 391 "anatomical structure morphogenesis [GO:0009653]; blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000978; GO:0001077; GO:0001824; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005737; GO:0006355; GO:0006954; GO:0009653; GO:0030154; GO:0030198; GO:0030855; GO:0045892; GO:0045893; GO:0045944; GO:0060056 0 0 0 PF00178;PF02198; Q4KME6 CHOYP_INT1.1.1 m.19028 sp PERQ2_DANRE 29.798 396 165 13 378 730 510 835 6.53E-30 131 PERQ2_DANRE reviewed PERQ amino acid-rich with GYF domain-containing protein 2 (Trinucleotide repeat-containing gene 15 protein) gigyf2 perq2 tnrc15 zgc:111944 Danio rerio (Zebrafish) (Brachydanio rerio) 1335 0 0 0 0 0 PF02213; Q5ND28 CHOYP_MEG10.74.91 m.57377 sp SREC_MOUSE 32.821 195 111 6 216 395 241 430 6.53E-20 96.3 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q60631 CHOYP_BM1_39900.1.1 m.38017 sp GRB2_MOUSE 50 118 57 1 5 120 97 214 6.53E-40 135 GRB2_MOUSE reviewed Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) Grb2 Mus musculus (Mouse) 217 aging [GO:0007568]; anatomical structure formation involved in morphogenesis [GO:0048646]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cell differentiation [GO:0030154]; cellular response to ionizing radiation [GO:0071479]; Fc-epsilon receptor signaling pathway [GO:0038095]; insulin receptor signaling pathway [GO:0008286]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein heterooligomerization [GO:0051291]; Ras protein signal transduction [GO:0007265]; receptor internalization [GO:0031623]; regulation of MAPK cascade [GO:0043408]; signal transduction in response to DNA damage [GO:0042770] GO:0005070; GO:0005154; GO:0005168; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005768; GO:0005794; GO:0005829; GO:0005886; GO:0005911; GO:0007265; GO:0007568; GO:0008180; GO:0008286; GO:0012506; GO:0016020; GO:0017124; GO:0019901; GO:0019903; GO:0019904; GO:0030154; GO:0030838; GO:0031623; GO:0038095; GO:0042770; GO:0042802; GO:0043408; GO:0043560; GO:0044822; GO:0046875; GO:0048646; GO:0051291; GO:0060670; GO:0070062; GO:0070436; GO:0071479; GO:2000379 0 0 0 PF00017;PF00018; Q6P9S1 CHOYP_ATMIN.1.1 m.22326 sp ATMIN_MOUSE 36.709 158 88 6 19 172 64 213 6.53E-23 102 ATMIN_MOUSE reviewed ATM interactor (ATM/ATR-substrate CHK2-interacting zinc finger protein) (ASCIZ) Atmin Kiaa0431 Mus musculus (Mouse) 818 "cellular response to DNA damage stimulus [GO:0006974]; cilium morphogenesis [GO:0060271]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006974; GO:0044212; GO:0045502; GO:0045893; GO:0046872; GO:0060271 0 0 0 0 Q8AVY1 CHOYP_NEMVEDRAFT_V1G243823.1.1 m.50085 sp ODF3A_XENLA 47.951 244 125 2 6 249 12 253 6.53E-69 215 ODF3A_XENLA reviewed Outer dense fiber protein 3 (Outer dense fiber of sperm tails protein 3) odf3 Xenopus laevis (African clawed frog) 256 0 GO:0005737 0 0 0 PF07004; Q8NB66 CHOYP_LOC100536829.2.2 m.22286 sp UN13C_HUMAN 26.984 189 120 6 107 289 246 422 6.53E-06 51.6 UN13C_HUMAN reviewed Protein unc-13 homolog C (Munc13-3) UNC13C Homo sapiens (Human) 2214 chemical synaptic transmission [GO:0007268]; exocytosis [GO:0006887]; intracellular signal transduction [GO:0035556] GO:0005737; GO:0005886; GO:0006887; GO:0007268; GO:0019992; GO:0030054; GO:0035556; GO:0042734; GO:0046872; GO:0048786 0 0 0 PF00130;PF00168;PF06292;PF10540; Q91WV7 CHOYP_BRAFLDRAFT_265208.6.7 m.52336 sp SLC31_MOUSE 31.847 628 374 16 21 619 46 648 6.53E-99 320 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q99MV7 CHOYP_RNF17.1.1 m.17312 sp RNF17_MOUSE 25 1268 738 36 463 1602 419 1601 6.53E-80 296 RNF17_MOUSE reviewed RING finger protein 17 (Mad member-interacting protein 2) (Mmip-2) Rnf17 Mus musculus (Mouse) 1640 multicellular organism development [GO:0007275]; spermatid development [GO:0007286] GO:0005634; GO:0005737; GO:0007275; GO:0007286; GO:0008270; GO:0042803 0 0 0 PF00567; Q9MZD1 CHOYP_PHUM_PHUM504500.1.1 m.9712 sp S17A5_SHEEP 34.921 378 226 8 34 392 98 474 6.53E-63 213 S17A5_SHEEP reviewed Sialin (Membrane glycoprotein SP55) (Sodium/sialic acid cotransporter) (Solute carrier family 17 member 5) SLC17A5 Ovis aries (Sheep) 495 0 GO:0005765; GO:0015293; GO:0016021 0 0 cd06174; PF07690; A2AV25 CHOYP_BRAFLDRAFT_252169.5.6 m.53653 sp FBCD1_MOUSE 41.667 252 126 7 261 501 214 455 6.54E-49 177 FBCD1_MOUSE reviewed Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) 459 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; O54834 CHOYP_LOC100366924.1.1 m.11208 sp RHG06_MOUSE 38.041 531 255 15 308 800 175 669 6.54E-84 295 RHG06_MOUSE reviewed Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1) Arhgap6 Mus musculus (Mouse) 987 actin filament organization [GO:0007015]; activation of phospholipase C activity [GO:0007202]; focal adhesion assembly [GO:0048041]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165] GO:0005096; GO:0005737; GO:0007015; GO:0007165; GO:0007202; GO:0015629; GO:0016004; GO:0043087; GO:0043547; GO:0048041; GO:0051497; GO:0051895 0 0 0 PF00620; P19965 CHOYP_LOC575515.1.1 m.61340 sp SP15_TETCF 23.393 560 378 20 172 700 105 644 6.54E-36 148 SP15_TETCF reviewed SITS-binding protein (SP105) 0 Tetronarce californica (Pacific electric ray) (Torpedo californica) 697 carbohydrate metabolic process [GO:0005975] GO:0004553; GO:0005975; GO:0016021 0 0 0 PF01055; Q12955 CHOYP_TVAG_099270.1.6 m.47699 sp ANK3_HUMAN 40.741 135 80 0 124 258 61 195 6.54E-23 101 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q25381 CHOYP_PAN2.1.1 m.44691 sp ACTM_LYTPI 71.296 108 30 1 13 120 27 133 6.54E-48 159 ACTM_LYTPI reviewed "Actin, muscle (LPM) (Fragment)" 0 Lytechinus pictus (Painted sea urchin) 172 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q5BKR2 CHOYP_LOC584015.1.1 m.10227 sp SL9B2_MOUSE 37.729 546 308 8 42 563 6 543 6.54E-114 353 SL9B2_MOUSE reviewed Mitochondrial sodium/hydrogen exchanger 9B2 (Mitochondrial Na(+)/H(+) exchanger NHA2) (NHA-oc) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) Slc9b2 Nha2 Nhedc2 Mus musculus (Mouse) 547 positive regulation of osteoclast development [GO:2001206]; sodium ion transport [GO:0006814] GO:0006814; GO:0015299; GO:0016021; GO:0031966; GO:2001206 0 0 0 PF00999; Q6AY22 CHOYP_LOC100374267.2.5 m.36178 sp SPAT1_RAT 36.41 195 110 5 392 585 248 429 6.54E-25 111 SPAT1_RAT reviewed Spermatogenesis-associated protein 1 Spata1 Rattus norvegicus (Rat) 444 0 0 0 0 0 PF15743; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.10.15 m.43361 sp SACS_MOUSE 26.452 155 90 5 57 199 4436 4578 6.54E-08 55.5 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9QWG7 CHOYP_SULT1ST5.1.1 m.59282 sp ST1B1_MOUSE 31.298 262 158 5 33 274 31 290 6.54E-41 146 ST1B1_MOUSE reviewed Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (DOPA/tyrosine sulfotransferase) Sult1b1 Mus musculus (Mouse) 299 epithelial cell differentiation [GO:0030855]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805] GO:0004062; GO:0005829; GO:0006805; GO:0008146; GO:0008202; GO:0009812; GO:0018958; GO:0030855; GO:0042403; GO:0051923 0 0 0 PF00685; Q9Y253 CHOYP_POLH.1.1 m.19465 sp POLH_HUMAN 50.722 485 219 6 2 470 6 486 6.54E-160 483 POLH_HUMAN reviewed DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein) POLH RAD30 RAD30A XPV Homo sapiens (Human) 713 cellular response to UV-C [GO:0071494]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; pyrimidine dimer repair [GO:0006290]; regulation of DNA repair [GO:0006282]; response to UV-C [GO:0010225]; translesion synthesis [GO:0019985] GO:0000731; GO:0003684; GO:0003887; GO:0005654; GO:0005737; GO:0006260; GO:0006281; GO:0006282; GO:0006290; GO:0010225; GO:0019985; GO:0046872; GO:0070987; GO:0071494 0 0 0 PF00817;PF11799; Q9Y493 CHOYP_NEMVEDRAFT_V1G247997.2.3 m.58161 sp ZAN_HUMAN 35.156 256 165 1 727 981 535 790 6.54E-18 94.4 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; H2A0M3 CHOYP_AMO.3.5 m.46022 sp AMO_PINMG 48.821 424 208 5 1 417 354 775 6.55E-132 400 AMO_PINMG reviewed Putative amine oxidase [copper-containing] (EC 1.4.3.-) 0 Pinctada margaritifera (Black-lipped pearl oyster) 781 amine metabolic process [GO:0009308] GO:0005507; GO:0005576; GO:0008131; GO:0009308; GO:0048038 0 0 0 PF01179; P23175 CHOYP_RAS.1.1 m.57089 sp RASH_MSVNS 86.628 172 23 0 1 172 1 172 6.55E-108 309 RASH_MSVNS reviewed GTPase HRas (Transforming protein p21/H-Ras) H-RAS Murine sarcoma virus NS.C58 189 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0007264; GO:0016020; GO:0020002 0 0 0 PF00071; Q1PRL4 CHOYP_BRAFLDRAFT_81815.1.1 m.39425 sp LIN41_CHICK 22.685 216 132 7 138 333 636 836 6.55E-06 51.6 LIN41_CHICK reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Gallus gallus (Chicken) 876 fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q28F39 CHOYP_LOC101236441.1.2 m.30281 sp CC134_XENTR 34.146 82 53 1 34 114 22 103 6.55E-08 53.5 CC134_XENTR reviewed Coiled-coil domain-containing protein 134 ccdc134 TGas125o12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 229 0 GO:0005576 0 0 0 PF15002; Q2M389 CHOYP_LOC100372619.1.2 m.32577 sp WASH7_HUMAN 54.412 68 31 0 63 130 597 664 6.55E-21 90.5 WASH7_HUMAN reviewed WASH complex subunit 7 (Strumpellin and WASH-interacting protein) (SWIP) KIAA1033 Homo sapiens (Human) 1173 endosomal transport [GO:0016197]; endosome organization [GO:0007032]; protein transport [GO:0015031] GO:0005654; GO:0005768; GO:0005769; GO:0007032; GO:0015031; GO:0016197; GO:0071203 0 0 0 PF14746;PF14744;PF14745; Q3HNG7 CHOYP_PPP1CC.1.1 m.13939 sp H1FOO_BOVIN 40.625 64 38 0 18 81 50 113 6.55E-11 63.5 H1FOO_BOVIN reviewed Histone H1oo (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) H1FOO H1OO Bos taurus (Bovine) 343 meiotic cell cycle [GO:0051321]; negative regulation of stem cell differentiation [GO:2000737]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; regulation of DNA methylation [GO:0044030] GO:0000786; GO:0005634; GO:0005737; GO:0006334; GO:0016584; GO:0031492; GO:0044030; GO:0051321; GO:2000737 0 0 0 PF00538; Q864S8 CHOYP_BRCA2.1.2 m.17654 sp BRCA2_FELCA 31.69 1278 699 44 1648 2831 1909 3106 6.55E-134 477 BRCA2_FELCA reviewed Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog) BRCA2 FANCD1 Felis catus (Cat) (Felis silvestris catus) 3372 "centrosome duplication [GO:0051298]; chromosome organization [GO:0051276]; cytokinesis [GO:0000910]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; nucleotide-excision repair [GO:0006289]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell proliferation [GO:0042127]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000724; GO:0000910; GO:0003697; GO:0005634; GO:0005813; GO:0006289; GO:0006302; GO:0006355; GO:0030141; GO:0033593; GO:0033600; GO:0042127; GO:0043015; GO:0043234; GO:0045893; GO:0051276; GO:0051298 0 0 0 PF09169;PF09103;PF09104;PF00634;PF09121; Q8VE99 CHOYP_LOC100693882.1.1 m.26097 sp CC115_MOUSE 29.348 184 115 4 5 184 3 175 6.55E-20 85.5 CC115_MOUSE reviewed Coiled-coil domain-containing protein 115 (Coiled-coil protein 1) (Ccp1) Ccdc115 Mus musculus (Mouse) 180 0 GO:0005764; GO:0005768; GO:0005793; GO:0016020; GO:0030137 0 0 0 0 Q95LU3 CHOYP_ANGP4.1.7 m.1122 sp FBCD1_MACFA 33.911 404 219 13 170 556 54 426 6.55E-54 191 FBCD1_MACFA reviewed Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 431 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q9C882 CHOYP_LOC100571125.1.1 m.5129 sp GTL1_ARATH 33.333 90 60 0 95 184 436 525 6.55E-06 50.8 GTL1_ARATH reviewed Trihelix transcription factor GTL1 (GT2-LIKE protein 1) (AtGTL1) (Protein GT-2-LIKE1) (Trihelix DNA-binding protein GTL1) GTL1 At1g33240 T16O9.10 T9L6.10 Arabidopsis thaliana (Mouse-ear cress) 587 "cellular response to water deprivation [GO:0042631]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of cell size [GO:0008361]; regulation of stomatal complex development [GO:2000038]; regulation of stomatal complex patterning [GO:2000037]; response to water deprivation [GO:0009414]; transcription, DNA-templated [GO:0006351]; trichome morphogenesis [GO:0010090]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0008361; GO:0009414; GO:0010090; GO:0030308; GO:0032876; GO:0042631; GO:0043565; GO:0045892; GO:2000037; GO:2000038 0 0 0 0 Q9DA39 CHOYP_BRAFLDRAFT_115358.2.2 m.51082 sp LFG4_MOUSE 50.216 231 115 0 38 268 2 232 6.55E-75 231 LFG4_MOUSE reviewed Protein lifeguard 4 (Transmembrane BAX inhibitor motif-containing protein 4) (Z-protein) Tmbim4 Lfg4 Mus musculus (Mouse) 238 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; regulation of calcium-mediated signaling [GO:0050848] GO:0000139; GO:0005795; GO:0006915; GO:0016021; GO:0043066; GO:0050848 0 0 0 0 Q9NUV9 CHOYP_LOC100017680.1.2 m.34195 sp GIMA4_HUMAN 38.71 279 164 3 89 362 22 298 6.55E-59 197 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9UHC1 CHOYP_MLH3.1.1 m.34117 sp MLH3_HUMAN 32.659 346 211 11 373 704 1044 1381 6.55E-41 165 MLH3_HUMAN reviewed DNA mismatch repair protein Mlh3 (MutL protein homolog 3) MLH3 Homo sapiens (Human) 1453 female meiosis I [GO:0007144]; male meiosis [GO:0007140]; mismatch repair [GO:0006298]; protein localization [GO:0008104]; reciprocal meiotic recombination [GO:0007131]; synaptonemal complex assembly [GO:0007130] GO:0000795; GO:0001673; GO:0003682; GO:0003696; GO:0003697; GO:0005524; GO:0005634; GO:0005712; GO:0006298; GO:0007130; GO:0007131; GO:0007140; GO:0007144; GO:0008104; GO:0016887; GO:0019237; GO:0030983; GO:0032300 0 0 0 PF01119;PF08676; Q9UI42 CHOYP_LOC100367625.1.1 m.15142 sp CBPA4_HUMAN 28.92 287 168 12 48 320 119 383 6.55E-19 91.7 CBPA4_HUMAN reviewed Carboxypeptidase A4 (EC 3.4.17.-) (Carboxypeptidase A3) CPA4 CPA3 UNQ694/PRO1339 Homo sapiens (Human) 421 histone acetylation [GO:0016573] GO:0004181; GO:0005615; GO:0008270; GO:0016573 0 0 0 PF00246;PF02244; O42449 CHOYP_DIO1.1.1 m.48087 sp IOD1_ORENI 53.846 117 54 0 1 117 130 246 6.56E-44 146 IOD1_ORENI reviewed Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) dio1 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 248 hormone biosynthetic process [GO:0042446] GO:0004800; GO:0005789; GO:0016021; GO:0042446 0 0 0 PF00837; O54902 CHOYP_NRAM2.1.1 m.32158 sp NRAM2_RAT 67.302 315 102 1 15 329 32 345 6.56E-147 430 NRAM2_RAT reviewed Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) Slc11a2 Dct1 Dmt1 Nramp2 Rattus norvegicus (Rat) 568 cellular copper ion homeostasis [GO:0006878]; cellular response to hypoxia [GO:0071456]; cellular response to iron ion [GO:0071281]; cellular response to tumor necrosis factor [GO:0071356]; copper ion import into cell [GO:1902861]; ferrous iron transport [GO:0015684]; iron ion homeostasis [GO:0055072]; response to cadmium ion [GO:0046686]; response to hypoxia [GO:0001666]; response to iron ion [GO:0010039]; response to lead ion [GO:0010288]; response to manganese ion [GO:0010042]; transition metal ion transport [GO:0000041] GO:0000041; GO:0001666; GO:0005375; GO:0005381; GO:0005384; GO:0005506; GO:0005507; GO:0005737; GO:0005741; GO:0005765; GO:0005769; GO:0005887; GO:0006878; GO:0008270; GO:0010039; GO:0010042; GO:0010288; GO:0015086; GO:0015087; GO:0015093; GO:0015094; GO:0015099; GO:0015639; GO:0015684; GO:0016021; GO:0016151; GO:0030145; GO:0031902; GO:0045177; GO:0046686; GO:0046870; GO:0050897; GO:0055072; GO:0071281; GO:0071356; GO:0071456; GO:1902861 0 0 0 PF01566; O96064 CHOYP_MYSP.4.9 m.2301 sp MYSP_MYTGA 79.703 202 41 0 1 202 663 864 6.56E-93 292 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; Q0Q028 CHOYP_LOC100377294.1.1 m.25275 sp DFP3_ANTMY 42.069 145 71 6 39 177 17 154 6.56E-25 99 DFP3_ANTMY reviewed Putative defense protein 3 (DFP-3) 0 Antheraea mylitta (Tasar silkworm) 163 defense response to bacterium [GO:0042742]; defense response to protozoan [GO:0042832]; innate immune response [GO:0045087] GO:0005576; GO:0042742; GO:0042832; GO:0045087 0 0 cd08544; PF02014; Q502K2 CHOYP_SAMH1.3.12 m.20264 sp SAMH1_DANRE 50.239 418 192 6 2 405 160 575 6.56E-133 398 SAMH1_DANRE reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) samhd1 Danio rerio (Zebrafish) (Brachydanio rerio) 622 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966;PF07647; Q5ZIJ9 CHOYP_BRAFLDRAFT_120990.10.18 m.51025 sp MIB2_CHICK 29.814 161 86 5 332 466 87 246 6.56E-09 62.8 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6P848 CHOYP_BRAFLDRAFT_90777.1.1 m.50497 sp MARE1_XENTR 54.054 222 90 7 6 221 54 269 6.56E-71 220 MARE1_XENTR reviewed Microtubule-associated protein RP/EB family member 1 mapre1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 269 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of microtubule polymerization [GO:0031115]; protein localization to microtubule [GO:0035372] GO:0005815; GO:0005874; GO:0007067; GO:0030981; GO:0031115; GO:0035372; GO:0051010; GO:0051301 0 0 0 PF00307;PF03271; Q7T163 CHOYP_LOC764549.3.3 m.61815 sp KDIS_DANRE 33.168 202 125 6 87 282 67 264 6.56E-19 90.1 KDIS_DANRE reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) 1672 nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; regulation of protein kinase activity [GO:0045859] GO:0005770; GO:0007399; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0045859 0 0 0 PF00023;PF12796;PF07693; Q86UZ6 CHOYP_IKZF3.2.2 m.66640 sp ZBT46_HUMAN 38.182 55 34 0 573 627 415 469 6.56E-09 62.4 ZBT46_HUMAN reviewed Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340) ZBTB46 BTBD4 ZNF340 Homo sapiens (Human) 589 "negative regulation of dendritic cell differentiation [GO:2001199]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of monocyte differentiation [GO:0045656]; positive regulation of dendritic cell differentiation [GO:2001200]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0030853; GO:0045650; GO:0045656; GO:0046872; GO:2001199; GO:2001200 0 0 0 PF00651; Q96J86 CHOYP_contig_048525 m.57522 sp CYYR1_HUMAN 33.6 125 73 5 1 119 14 134 6.56E-06 46.6 CYYR1_HUMAN reviewed Cysteine and tyrosine-rich protein 1 (Proline-rich domain-containing protein) CYYR1 C21orf95 Homo sapiens (Human) 154 0 GO:0016021 0 0 0 PF10873; Q96RW7 CHOYP_HMCN1.3.44 m.5235 sp HMCN1_HUMAN 38.095 231 105 7 108 302 4528 4756 6.56E-36 143 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q96RW7 CHOYP_ISCW_ISCW014027.2.2 m.43957 sp HMCN1_HUMAN 23.611 720 420 30 228 881 3683 4338 6.56E-20 100 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9NFT7 CHOYP_DPSE_GA15574.1.1 m.62967 sp HXK2_DROME 38.514 444 260 8 21 458 41 477 6.56E-102 316 HXK2_DROME reviewed Hexokinase type 2 (EC 2.7.1.1) Hex-t2 Hex CG32849 Drosophila melanogaster (Fruit fly) 486 cellular glucose homeostasis [GO:0001678]; fructose metabolic process [GO:0006000]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; mannose metabolic process [GO:0006013] GO:0001678; GO:0004340; GO:0004396; GO:0005524; GO:0005536; GO:0005829; GO:0006000; GO:0006006; GO:0006013; GO:0006096; GO:0008865; GO:0019158 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF00349;PF03727; A8FZZ3 CHOYP_BRAFLDRAFT_84796.1.1 m.3999 sp HLDE_SHESH 30.769 143 89 6 361 499 332 468 6.57E-10 65.1 HLDE_SHESH reviewed Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase (EC 2.7.1.167) (D-beta-D-heptose 7-phosphotransferase) (D-glycero-beta-D-manno-heptose-7-phosphate kinase); D-beta-D-heptose 1-phosphate adenylyltransferase (EC 2.7.7.70) (D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase)] hldE Ssed_3812 Shewanella sediminis (strain HAW-EB3) 476 ADP-L-glycero-beta-D-manno-heptose biosynthetic process [GO:0097171] GO:0005524; GO:0016773; GO:0033785; GO:0033786; GO:0097171 PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4. {ECO:0000255|HAMAP-Rule:MF_01603}.; PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4. {ECO:0000255|HAMAP-Rule:MF_01603}. 0 cd01172; PF01467;PF00294; F4KGU4 CHOYP_LOC100632169.3.6 m.51390 sp DEAHC_ARATH 33.843 1046 612 26 155 1150 216 1231 6.57E-151 499 DEAHC_ARATH reviewed "ATP-dependent RNA helicase DEAH12, chloroplastic (EC 3.6.4.13)" At5g10370 F12B17_280 Arabidopsis thaliana (Mouse-ear cress) 1775 RNA processing [GO:0006396] GO:0004004; GO:0005524; GO:0005634; GO:0005737; GO:0006396; GO:0008270; GO:0009507; GO:0044822 0 0 0 PF00270;PF04408;PF00271;PF01485;PF07717;PF13445; P08548 CHOYP_LOC100536544.1.1 m.53382 sp LIN1_NYCCO 28.474 439 277 14 162 568 342 775 6.57E-30 130 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; Q11176 CHOYP_ISCW_ISCW011023.1.1 m.37891 sp WDR1_CAEEL 41.86 129 71 3 74 199 484 611 6.57E-25 104 WDR1_CAEEL reviewed Actin-interacting protein 1 (AIP1) (Uncoordinated protein 78) unc-78 C04F6.4 Caenorhabditis elegans 611 locomotion [GO:0040011]; muscle thin filament assembly [GO:0071689]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of actin filament depolymerization [GO:0030836]; regulation of locomotion [GO:0040012]; skeletal muscle thin filament assembly [GO:0030240] GO:0003779; GO:0016528; GO:0030016; GO:0030240; GO:0030836; GO:0030837; GO:0040011; GO:0040012; GO:0042643; GO:0051015; GO:0071689 0 0 0 PF12894;PF00400; Q14162 CHOYP_MEG10.60.91 m.49159 sp SREC_HUMAN 39.535 86 51 1 201 286 274 358 6.57E-13 72 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q19417 CHOYP_NEMVEDRAFT_V1G248075.1.1 m.2824 sp YSNK_CAEEL 27.354 223 147 7 84 298 50 265 6.57E-07 55.1 YSNK_CAEEL reviewed Glycosyltransferase family 92 protein F13G3.3 (EC 2.4.1.-) F13G3.3 Caenorhabditis elegans 501 0 GO:0016021; GO:0016757 0 0 0 PF01697; Q53FA7 CHOYP_BRAFLDRAFT_57258.2.3 m.48328 sp QORX_HUMAN 55.891 331 141 3 14 340 1 330 6.57E-124 362 QORX_HUMAN reviewed Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein) TP53I3 PIG3 Homo sapiens (Human) 332 NADP metabolic process [GO:0006739]; regulation of apoptotic process [GO:0042981] GO:0003960; GO:0005829; GO:0006739; GO:0008270; GO:0042803; GO:0042981; GO:0048038; GO:0070062; GO:0070402 0 0 0 PF08240;PF00107; Q5BKL8 CHOYP_XIAP.1.7 m.6021 sp XIAP_XENTR 23.556 225 142 5 295 490 268 491 6.57E-10 64.7 XIAP_XENTR reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 492 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of proteolysis [GO:0045861]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005737; GO:0007275; GO:0008270; GO:0016055; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0045861; GO:0090263; GO:1990001 0 0 0 PF00653; Q6ZRF8 CHOYP_LOC100370758.2.3 m.53293 sp RN207_HUMAN 24.324 222 138 10 43 258 103 300 6.57E-07 55.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7ZY85 CHOYP_LOC100370348.1.1 m.22989 sp NEPR1_XENLA 64.198 81 27 1 9 87 3 83 6.57E-30 106 NEPR1_XENLA reviewed Nuclear envelope phosphatase-regulatory subunit 1 (Transmembrane protein 188) cnep1r1 tmem188 Xenopus laevis (African clawed frog) 125 lipid metabolic process [GO:0006629]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of triglyceride biosynthetic process [GO:0010867] GO:0005737; GO:0006629; GO:0010867; GO:0016021; GO:0031965; GO:0035307; GO:0071595 0 0 0 PF09771; Q8MSU3 CHOYP_AAEL_AAEL006322.2.3 m.42353 sp FRRS1_DROME 28.015 539 332 17 18 517 32 553 6.57E-58 208 FRRS1_DROME reviewed Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) CG8399 Drosophila melanogaster (Fruit fly) 647 oxidation-reduction process [GO:0055114] GO:0000293; GO:0016021; GO:0055114 0 0 cd08544; PF03188;PF03351;PF02014; Q99M80 CHOYP_LOC101137975.1.1 m.46958 sp PTPRT_MOUSE 31.103 553 339 13 211 737 770 1306 6.57E-69 250 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9H147 CHOYP_ISCW_ISCW008626.1.1 m.36984 sp TDIF1_HUMAN 41.912 272 139 6 732 998 60 317 6.57E-60 211 TDIF1_HUMAN reviewed Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1) DNTTIP1 C20orf167 TDIF1 Homo sapiens (Human) 329 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0003677; GO:0005634; GO:0005654; GO:0005730; GO:0006351; GO:0006355; GO:0031491; GO:0042803 0 0 0 0 B0C431 CHOYP_LOC580666.1.2 m.21929 sp RS11_ACAM1 40.187 107 64 0 76 182 21 127 6.58E-24 95.9 RS11_ACAM1 reviewed 30S ribosomal protein S11 rpsK rps11 AM1_1254 Acaryochloris marina (strain MBIC 11017) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00411; O75095 CHOYP_LOC100184792.1.3 m.2741 sp MEGF6_HUMAN 30.829 772 435 41 17 735 691 1416 6.58E-49 190 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P54213 CHOYP_NEMVEDRAFT_V1G102533.1.1 m.30046 sp CATR_DUNSA 35.333 150 96 1 198 347 21 169 6.58E-21 91.7 CATR_DUNSA reviewed Caltractin (Centrin) 0 Dunaliella salina (Green alga) (Protococcus salinus) 169 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005509; GO:0007067; GO:0051301 0 0 0 PF13499; P79702 CHOYP_ISCW_ISCW010628.1.1 m.2528 sp FOS_CYPCA 56.471 85 37 0 139 223 101 185 6.58E-26 108 FOS_CYPCA reviewed Proto-oncogene c-Fos (Cellular oncogene fos) fos Cyprinus carpio (Common carp) 347 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0003700; GO:0005634; GO:0005667; GO:0006357; GO:0043565 0 0 0 PF00170; Q25381 CHOYP_LOC101069692.1.1 m.2442 sp ACTM_LYTPI 95.192 104 5 0 1 104 69 172 6.58E-72 214 ACTM_LYTPI reviewed "Actin, muscle (LPM) (Fragment)" 0 Lytechinus pictus (Painted sea urchin) 172 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q3ZAV0 CHOYP_LOC764890.1.1 m.29296 sp CCD60_RAT 24.714 611 315 23 136 728 44 527 6.58E-32 134 CCD60_RAT reviewed Coiled-coil domain-containing protein 60 Ccdc60 Rattus norvegicus (Rat) 542 0 0 0 0 0 PF15769; Q568Y5 CHOYP_ALDR.1.1 m.50076 sp TSN11_RAT 37.553 237 139 5 5 234 13 247 6.58E-44 151 TSN11_RAT reviewed Tetraspanin-11 (Tspan-11) Tspan11 Rattus norvegicus (Rat) 253 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q5BJR4 CHOYP_PRUN2.1.1 m.38759 sp PRUN2_RAT 54.826 259 87 5 1526 1754 30 288 6.58E-88 293 PRUN2_RAT reviewed Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1) Prune2 Bmcc1 Rattus norvegicus (Rat) 322 apoptotic process [GO:0006915] GO:0005737; GO:0006915 0 0 0 PF12496;PF13716; Q90YV7 CHOYP_RL11.7.7 m.50505 sp RL11_ICTPU 82.278 158 20 1 90 247 2 151 6.58E-90 266 RL11_ICTPU reviewed 60S ribosomal protein L11 rpl11 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 178 protein localization to nucleus [GO:0034504]; translation [GO:0006412] GO:0003735; GO:0005730; GO:0005840; GO:0006412; GO:0019843; GO:0034504 0 0 0 PF00281;PF00673; Q99M80 CHOYP_PTPRK.4.20 m.2624 sp PTPRT_MOUSE 30 720 441 15 355 1041 764 1453 6.58E-83 298 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9CYB0 CHOYP_LOC100367817.7.7 m.53842 sp TRI13_MOUSE 24.103 195 129 5 41 231 78 257 6.58E-08 58.2 TRI13_MOUSE reviewed E3 ubiquitin-protein ligase TRIM13 (EC 6.3.2.-) (Putative tumor suppressor RFP2) (Ret finger protein 2) (Tripartite motif-containing protein 13) Trim13 Rfp2 Mus musculus (Mouse) 407 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; innate immune response [GO:0045087]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell death [GO:0010942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macroautophagy [GO:0016239]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; response to gamma radiation [GO:0010332] GO:0004842; GO:0004871; GO:0005737; GO:0005789; GO:0008270; GO:0010332; GO:0010942; GO:0016021; GO:0016239; GO:0016874; GO:0030433; GO:0032897; GO:0043123; GO:0043161; GO:0045087; GO:0051092; GO:0051865; GO:0097038; GO:1902187 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q9CZJ2 CHOYP_BRAFLDRAFT_240123.5.6 m.44697 sp HS12B_MOUSE 34.135 416 216 12 11 373 61 471 6.58E-59 205 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9UKK3 CHOYP_LOC100373327.11.13 m.52203 sp PARP4_HUMAN 37.556 892 495 22 4 865 66 925 6.58E-163 520 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; Q9WV72 CHOYP_TVAG_388180.6.8 m.61149 sp ASB3_MOUSE 29.082 196 108 3 406 582 54 237 6.58E-14 78.2 ASB3_MOUSE reviewed Ankyrin repeat and SOCS box protein 3 (ASB-3) Asb3 Mus musculus (Mouse) 525 intracellular signal transduction [GO:0035556] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0031625; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF13606;PF07525; D3YXG0 CHOYP_BRAFLDRAFT_69336.1.2 m.47928 sp HMCN1_MOUSE 33.78 373 170 11 230 584 4527 4840 6.59E-50 200 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O43301 CHOYP_BRAFLDRAFT_208197.11.21 m.41192 sp HS12A_HUMAN 41.053 95 47 5 31 123 57 144 6.59E-13 67.8 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P0C221 CHOYP_LOC577287.2.2 m.62297 sp CC175_HUMAN 27.313 227 161 4 13 237 45 269 6.59E-08 60.1 CC175_HUMAN reviewed Coiled-coil domain-containing protein 175 CCDC175 C14orf38 Homo sapiens (Human) 793 0 0 0 0 0 0 P16157 CHOYP_AFUA_1G01020.18.50 m.23841 sp ANK1_HUMAN 39.053 338 204 2 8 344 221 557 6.59E-60 211 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P86862 CHOYP_PHUM_PHUM241330.1.3 m.29131 sp VKT1_ANTEL 47.273 55 29 0 76 130 4 58 6.59E-12 63.2 VKT1_ANTEL reviewed KappaPI-actitoxin-Ael3a (KappaPI-AITX-Ael3a) (Kunitz-type serine protease inhibitor APEKTx1) 0 Anthopleura elegantissima (Sea anemone) 65 0 GO:0004867; GO:0005576; GO:0019870; GO:0042151 0 0 0 PF00014; Q15825 CHOYP_ACHA3.1.2 m.29281 sp ACHA6_HUMAN 27.851 456 260 14 29 423 32 479 6.59E-50 179 ACHA6_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 Homo sapiens (Human) 494 "chemical synaptic transmission [GO:0007268]; membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; transport [GO:0006810]" GO:0004889; GO:0005886; GO:0005892; GO:0006810; GO:0007165; GO:0007268; GO:0007271; GO:0007274; GO:0014059; GO:0015276; GO:0015464; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q1RMU2 CHOYP_BRAFLDRAFT_230143.1.1 m.15015 sp CYLD_BOVIN 36.443 922 498 21 74 963 88 953 6.59E-176 539 CYLD_BOVIN reviewed Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) CYLD CYLD1 Bos taurus (Bovine) 953 necroptotic process [GO:0070266]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell differentiation [GO:0045581]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein K63-linked deubiquitination [GO:0070536]; regulation of cilium assembly [GO:1902017]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of mitotic cell cycle [GO:0007346]; ripoptosome assembly involved in necroptotic process [GO:1901026]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055] GO:0004843; GO:0005813; GO:0005819; GO:0005829; GO:0005881; GO:0006511; GO:0007346; GO:0008270; GO:0016055; GO:0030496; GO:0031234; GO:0032088; GO:0036064; GO:0042347; GO:0045581; GO:0048471; GO:0061578; GO:0070266; GO:0070507; GO:0070536; GO:0090090; GO:0097542; GO:1901026; GO:1902017; GO:2001238; GO:2001242 0 0 0 PF01302;PF00443; Q5G265 CHOYP_LOC562156.2.2 m.64923 sp NETR_SAGLB 36.021 769 413 19 933 1685 165 870 6.59E-129 428 NETR_SAGLB reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Saguinus labiatus (Red-chested mustached tamarin) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5T9S5 CHOYP_LOC100372626.2.2 m.47978 sp CCD18_HUMAN 28.735 1312 828 21 141 1408 123 1371 6.59E-107 377 CCD18_HUMAN reviewed Coiled-coil domain-containing protein 18 (Sarcoma antigen NY-SAR-24) CCDC18 Homo sapiens (Human) 1454 0 0 0 0 0 0 Q5XI42 CHOYP_LOC100168209.1.1 m.26697 sp AL3B1_RAT 51.299 462 223 2 1 461 1 461 6.59E-178 510 AL3B1_RAT reviewed Aldehyde dehydrogenase family 3 member B1 (EC 1.2.1.5) Aldh3b1 Rattus norvegicus (Rat) 468 cellular aldehyde metabolic process [GO:0006081]; ethanol catabolic process [GO:0006068] GO:0004028; GO:0004029; GO:0004030; GO:0005886; GO:0006068; GO:0006081 PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. 0 0 PF00171; Q60787 CHOYP_LCP2.10.14 m.30020 sp LCP2_MOUSE 36.885 122 74 2 561 679 402 523 6.59E-18 91.3 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q7Z5Q5 CHOYP_POLN.1.1 m.46415 sp DPOLN_HUMAN 37.754 739 402 15 355 1057 143 859 6.59E-141 449 DPOLN_HUMAN reviewed DNA polymerase nu (EC 2.7.7.7) POLN Homo sapiens (Human) 900 DNA-dependent DNA replication [GO:0006261]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985] GO:0000724; GO:0003677; GO:0003887; GO:0005634; GO:0005654; GO:0005737; GO:0006261; GO:0008409; GO:0019985; GO:0030332; GO:0036297 0 0 0 PF00476; Q80SY5 CHOYP_LOC100745256.1.1 m.36335 sp PR38B_MOUSE 81.081 148 26 1 6 153 42 187 6.59E-76 238 PR38B_MOUSE reviewed Pre-mRNA-splicing factor 38B Prpf38b Mus musculus (Mouse) 542 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0006397; GO:0008380; GO:0044822; GO:0071011 0 0 0 PF03371; Q80U87 CHOYP_LOC100367006.2.2 m.17211 sp UBP8_MOUSE 41.433 642 343 9 513 1142 451 1071 6.59E-144 464 UBP8_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (mUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) Usp8 Kiaa0055 Ubpy Mus musculus (Mouse) 1080 endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000281; GO:0004843; GO:0005622; GO:0005654; GO:0005737; GO:0005769; GO:0005794; GO:0005829; GO:0006511; GO:0007032; GO:0007265; GO:0016579; GO:0019897; GO:0030496; GO:0031313; GO:0070536; GO:0071108 0 0 0 PF00581;PF00443;PF08969; Q86V71 CHOYP_ZNF836.1.1 m.17328 sp ZN429_HUMAN 38.428 458 237 6 210 641 209 647 6.59E-94 308 ZN429_HUMAN reviewed Zinc finger protein 429 ZNF429 Homo sapiens (Human) 674 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q8VIG3 CHOYP_EIF3C.1.1 m.7993 sp RSPH1_MOUSE 50 200 100 0 11 210 79 278 6.59E-57 186 RSPH1_MOUSE reviewed Radial spoke head 1 homolog (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) Rsph1 Tsga2 Mus musculus (Mouse) 301 axoneme assembly [GO:0035082]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] GO:0000794; GO:0001520; GO:0005634; GO:0005737; GO:0005829; GO:0007286; GO:0031514; GO:0035082; GO:0036126; GO:0051321; GO:0072687 0 0 0 PF02493; Q90673 CHOYP_LOC100741658.1.1 m.7343 sp PRLD1_CHICK 43.069 202 108 4 2 200 3 200 6.59E-47 156 PRLD1_CHICK reviewed "PRELI domain-containing protein 1, mitochondrial (Px19-like protein)" PRELID1 Gallus gallus (Chicken) 215 apoptotic process [GO:0006915] GO:0005739; GO:0005758; GO:0006915; GO:1990050 0 0 0 PF04707; Q96MM6 CHOYP_BRAFLDRAFT_208436.1.32 m.14239 sp HS12B_HUMAN 35.276 635 337 15 100 672 64 686 6.59E-118 370 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BXJ4 CHOYP_C1QTNF3.1.1 m.40751 sp C1QT3_HUMAN 28.221 163 104 6 13 166 84 242 6.59E-09 56.6 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9FFU6 CHOYP_NEMVEDRAFT_V1G243101.1.2 m.13940 sp B561A_ARATH 32.051 156 98 2 388 535 660 815 6.59E-16 85.1 B561A_ARATH reviewed "Cytochrome b561, DM13 and DOMON domain-containing protein At5g54830 (Protein b561A.tha1)" At5g54830 MBG8_9 Arabidopsis thaliana (Mouse-ear cress) 907 oxidation-reduction process [GO:0055114] GO:0005768; GO:0005794; GO:0005802; GO:0016021; GO:0046872; GO:0055114 0 0 0 PF03188;PF10517;PF03351; Q9Y426 CHOYP_LOC100367954.2.2 m.66596 sp CU025_HUMAN 30.921 152 100 2 75 226 238 384 6.59E-14 73.6 CU025_HUMAN reviewed C2 domain-containing protein 2 C2CD2 C21orf25 C21orf258 Homo sapiens (Human) 696 0 GO:0005576; GO:0005634; GO:0005829 0 0 0 PF00168; O70277 CHOYP_BRAFLDRAFT_109858.4.6 m.40842 sp TRIM3_RAT 27.966 118 77 3 20 131 579 694 6.60E-09 56.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P42577 CHOYP_LOC100533455.7.9 m.45962 sp FRIS_LYMST 78.632 117 25 0 25 141 51 167 6.60E-65 198 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; Q03348 CHOYP_PTPRA.18.22 m.58314 sp PTPRA_RAT 29.146 597 376 17 11 578 156 734 6.60E-65 229 PTPRA_RAT reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) 796 oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714] GO:0004725; GO:0005886; GO:0016021; GO:0032403; GO:0043231; GO:0048709; GO:0048714 0 0 0 PF00102; Q14978 CHOYP_NOLC1.2.3 m.45918 sp NOLC1_HUMAN 59.292 113 40 2 694 801 588 699 6.60E-32 136 NOLC1_HUMAN reviewed Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) NOLC1 KIAA0035 NS5ATP13 Homo sapiens (Human) 699 cell cycle [GO:0007049]; mitotic nuclear division [GO:0007067]; nucleolus organization [GO:0007000]; rRNA processing [GO:0006364] GO:0005524; GO:0005525; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0007000; GO:0007049; GO:0007067; GO:0015030; GO:0044822 0 0 0 PF05022; Q28FF3 CHOYP_contig_015855 m.18575 sp MFS7A_XENTR 33.333 90 50 2 1 90 402 481 6.60E-06 46.2 MFS7A_XENTR reviewed Major facilitator superfamily domain-containing protein 7-a mfsd7-A TEgg026p17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 482 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q3UPW2 CHOYP_ELF3.1.1 m.56002 sp ELF3_MOUSE 34.337 332 170 12 181 493 74 376 6.60E-41 154 ELF3_MOUSE reviewed ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) Elf3 Ert Esx Jen Mus musculus (Mouse) 391 "anatomical structure morphogenesis [GO:0009653]; blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; mammary gland involution [GO:0060056]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000978; GO:0001077; GO:0001824; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005737; GO:0006355; GO:0006954; GO:0009653; GO:0030154; GO:0030198; GO:0030855; GO:0045892; GO:0045893; GO:0045944; GO:0060056 0 0 0 PF00178;PF02198; Q5ZIM6 CHOYP_AATF.1.1 m.34004 sp AATF_CHICK 40.336 595 300 12 3 572 5 569 6.60E-115 356 AATF_CHICK reviewed Protein AATF (Apoptosis-antagonizing transcription factor) AATF RCJMB04_24o4 Gallus gallus (Chicken) 574 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0005730; GO:0006357 0 0 0 PF13339;PF08164; Q8J0I9 CHOYP_DFER_5601.1.1 m.49215 sp GUN16_TRIHA 33.262 466 279 10 26 468 30 486 6.60E-71 236 GUN16_TRIHA reviewed "Endo-1,6-beta-D-glucanase BGN16.3 (EC 3.2.1.75) (Beta-1,6-glucanase BGN16.3) (Glucan endo-1,6-beta-glucosidase BGN16.3)" 0 Trichoderma harzianum (Hypocrea lixii) 490 polysaccharide metabolic process [GO:0005976]; sphingolipid metabolic process [GO:0006665] GO:0004348; GO:0005576; GO:0005615; GO:0005976; GO:0006665; GO:0016798; GO:0046557 0 0 0 PF02055;PF17189; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.13.34 m.32154 sp VWDE_HUMAN 24.205 566 353 24 49 572 54 585 6.60E-23 110 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8N2E2 CHOYP_VWDE.6.13 m.31697 sp VWDE_HUMAN 26.63 368 242 12 677 1025 749 1107 6.60E-23 109 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8TEJ3 CHOYP_LOC101155413.1.1 m.53481 sp SH3R3_HUMAN 36.036 888 414 28 1 785 46 882 6.60E-139 435 SH3R3_HUMAN reviewed SH3 domain-containing RING finger protein 3 (Plenty of SH3s 2) (SH3 multiple domains protein 4) SH3RF3 POSH2 SH3MD4 Homo sapiens (Human) 882 0 GO:0008270 0 0 0 PF00018;PF14604; Q99M80 CHOYP_PTPRF.4.6 m.43066 sp PTPRT_MOUSE 28.511 705 452 18 284 961 772 1451 6.60E-73 267 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9PTG8 CHOYP_TACC3.3.3 m.16099 sp TACC3_XENLA 31.463 410 218 10 709 1112 577 929 6.60E-38 157 TACC3_XENLA reviewed Transforming acidic coiled-coil-containing protein 3 (Cytoplasmic polyadenylation element-binding protein-associated factor Maskin) (CPEB-associated factor Maskin) tacc3 maskin Xenopus laevis (African clawed frog) 931 negative regulation of translation [GO:0017148] GO:0005737; GO:0017148; GO:0031369; GO:0043234 0 0 0 PF05010; O14095 CHOYP_LOC585158.1.2 m.18137 sp PLP1_SCHPO 40.594 202 113 5 30 230 82 277 6.61E-39 139 PLP1_SCHPO reviewed Thioredoxin domain-containing protein plp1 (Phosducin-like protein 1) plp1 SPAC2F3.12c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 279 cell redox homeostasis [GO:0045454]; negative regulation of signal transduction [GO:0009968]; queuosine biosynthetic process [GO:0008616]; response to pheromone [GO:0019236] GO:0005634; GO:0005737; GO:0005829; GO:0008616; GO:0009968; GO:0019236; GO:0045454 0 0 0 PF00085; O70273 CHOYP_ETS4.2.2 m.50485 sp EHF_MOUSE 44.444 99 51 2 178 274 200 296 6.61E-20 90.5 EHF_MOUSE reviewed ETS homologous factor (ETS domain-containing transcription factor) Ehf Mus musculus (Mouse) 300 "cell differentiation [GO:0030154]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]" GO:0000978; GO:0000981; GO:0001077; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005794; GO:0006357; GO:0030154; GO:0030855; GO:0045893; GO:0045944; GO:0050673 0 0 0 PF00178;PF02198; O95613 CHOYP_LOC100186299.1.6 m.7813 sp PCNT_HUMAN 28.695 927 569 24 2772 3675 2446 3303 6.61E-66 254 PCNT_HUMAN reviewed Pericentrin (Kendrin) (Pericentrin-B) PCNT KIAA0402 PCNT2 Homo sapiens (Human) 3336 cilium assembly [GO:0042384]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; positive regulation of intracellular protein transport [GO:0090316] GO:0000086; GO:0000226; GO:0005737; GO:0005813; GO:0005814; GO:0005829; GO:0005874; GO:0007052; GO:0016020; GO:0034451; GO:0042384; GO:0090316 0 0 0 PF10495; P25067 CHOYP_LOC101067709.1.1 m.51220 sp CO8A2_HUMAN 34.579 107 65 3 76 181 574 676 6.61E-09 58.2 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; P54277 CHOYP_PMS1.1.3 m.16067 sp PMS1_HUMAN 34.819 965 493 28 12 916 1 889 6.61E-144 453 PMS1_HUMAN reviewed PMS1 protein homolog 1 (DNA mismatch repair protein PMS1) PMS1 PMSL1 Homo sapiens (Human) 932 mismatch repair [GO:0006298] GO:0000795; GO:0003677; GO:0003697; GO:0005524; GO:0005634; GO:0005712; GO:0006298; GO:0016887; GO:0030983; GO:0032389 0 0 0 PF01119;PF00505; Q3HNG7 CHOYP_BRAFLDRAFT_190162.2.5 m.6549 sp H1FOO_BOVIN 40.909 66 39 0 16 81 48 113 6.61E-12 66.2 H1FOO_BOVIN reviewed Histone H1oo (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) H1FOO H1OO Bos taurus (Bovine) 343 meiotic cell cycle [GO:0051321]; negative regulation of stem cell differentiation [GO:2000737]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; regulation of DNA methylation [GO:0044030] GO:0000786; GO:0005634; GO:0005737; GO:0006334; GO:0016584; GO:0031492; GO:0044030; GO:0051321; GO:2000737 0 0 0 PF00538; Q3SX45 CHOYP_TVAG_313830.4.4 m.61142 sp ASB2_BOVIN 29.644 253 137 6 704 946 134 355 6.61E-20 98.6 ASB2_BOVIN reviewed Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) 633 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q8R034 CHOYP_ISCW_ISCW010874.2.2 m.9190 sp APC13_MOUSE 59.459 74 30 0 37 110 1 74 6.61E-26 95.1 APC13_MOUSE reviewed Anaphase-promoting complex subunit 13 (APC13) (Cyclosome subunit 13) Anapc13 Mus musculus (Mouse) 74 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; protein K11-linked ubiquitination [GO:0070979] GO:0005680; GO:0007067; GO:0051301; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF05839; Q8SWR3 CHOYP_MSR.1.1 m.44290 sp SPR_DROME 25.378 331 213 13 16 325 81 398 6.61E-18 87.8 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q8TDX9 CHOYP_REJ7.1.1 m.3824 sp PK1L1_HUMAN 23.559 1371 841 46 195 1497 424 1655 6.61E-60 232 PK1L1_HUMAN reviewed Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1) PKD1L1 UNQ5785/PRO19563 Homo sapiens (Human) 2849 detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986]; single organismal cell-cell adhesion [GO:0016337] GO:0003127; GO:0005262; GO:0005929; GO:0016020; GO:0016337; GO:0031513; GO:0034704; GO:0050982; GO:0060170; GO:0070986 0 0 0 PF00801;PF08016;PF01477;PF02010; Q90744 CHOYP_NAGA-A.1.1 m.55104 sp NAGAB_CHICK 49.249 333 157 5 25 352 1 326 6.61E-109 329 NAGAB_CHICK reviewed Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) NAGA Gallus gallus (Chicken) 405 carbohydrate metabolic process [GO:0005975]; glycoside catabolic process [GO:0016139] GO:0004557; GO:0005737; GO:0005764; GO:0005975; GO:0008456; GO:0016139 0 0 cd14792; PF16499; Q96GP6 CHOYP_MEG10.17.91 m.24077 sp SREC2_HUMAN 40.351 114 62 4 207 317 250 360 6.61E-15 79 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_84664.4.7 m.37639 sp TRIM2_MOUSE 25.373 268 161 9 1109 1355 482 731 6.61E-10 67.4 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9N0A8 CHOYP_ARHGEF3.1.1 m.13898 sp ARHG3_MACFA 48.349 424 213 3 55 474 30 451 6.61E-134 405 ARHG3_MACFA reviewed Rho guanine nucleotide exchange factor 3 ARHGEF3 QccE-16434 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 526 intracellular signal transduction [GO:0035556]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005737; GO:0035023; GO:0035556 0 0 0 PF00621; Q9P2E3 CHOYP_ZNFX1.8.12 m.51965 sp ZNFX1_HUMAN 31.845 336 203 7 2 318 1454 1782 6.61E-44 164 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 O01359 CHOYP_RLA1.8.12 m.25631 sp RLA1_OSCTI 60.714 112 44 0 11 122 1 112 6.62E-33 114 RLA1_OSCTI reviewed 60S acidic ribosomal protein P1 (Ribosomal protein RPL-21) rpl-21 Oscheius tipulae 112 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O35115 CHOYP_LOC100160412.1.2 m.1215 sp FHL2_RAT 56.886 167 72 0 1 167 112 278 6.62E-71 218 FHL2_RAT reviewed Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3) Fhl2 Dral Slim3 Rattus norvegicus (Rat) 279 "atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoblast differentiation [GO:0001649]; response to hormone [GO:0009725]; transcription, DNA-templated [GO:0006351]; ventricular cardiac muscle cell development [GO:0055015]" GO:0000122; GO:0001649; GO:0005634; GO:0005925; GO:0006351; GO:0008134; GO:0008270; GO:0009725; GO:0015629; GO:0030018; GO:0031430; GO:0043066; GO:0055014; GO:0055015; GO:0060347 0 0 0 PF00412; P18433 CHOYP_PTPRE.15.19 m.50668 sp PTPRA_HUMAN 28.125 672 434 21 80 723 138 788 6.62E-64 231 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P24733 CHOYP_MYS.1.7 m.433 sp MYS_ARGIR 65.766 444 130 5 19 456 568 995 6.62E-172 532 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P45446 CHOYP_SMP_034860.1.1 m.66256 sp RORB_RAT 24.086 465 282 13 249 674 16 448 6.62E-26 115 RORB_RAT reviewed Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) Rorb Nr1f2 Rzrb Rattus norvegicus (Rat) 470 "amacrine cell differentiation [GO:0035881]; brain development [GO:0007420]; cellular response to retinoic acid [GO:0071300]; circadian rhythm [GO:0007623]; eye photoreceptor cell development [GO:0042462]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; response to hormone [GO:0009725]; retina development in camera-type eye [GO:0060041]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; transcription, DNA-templated [GO:0006351]; visual perception [GO:0007601]" GO:0003700; GO:0003707; GO:0004879; GO:0005634; GO:0006351; GO:0007420; GO:0007601; GO:0007623; GO:0008270; GO:0008502; GO:0009725; GO:0035881; GO:0042462; GO:0042752; GO:0043565; GO:0045668; GO:0045892; GO:0045893; GO:0046548; GO:0046549; GO:0060041; GO:0071300 0 0 0 PF00104;PF00105; P50430 CHOYP_BRAFLDRAFT_206907.3.11 m.16401 sp ARSB_RAT 38.667 375 188 7 5 342 149 518 6.62E-79 253 ARSB_RAT reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb Rattus norvegicus (Rat) 528 autophagy [GO:0006914]; central nervous system development [GO:0007417]; colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632]; response to estrogen [GO:0043627]; response to methylmercury [GO:0051597]; response to nutrient [GO:0007584]; response to pH [GO:0009268] GO:0003943; GO:0004065; GO:0005739; GO:0005764; GO:0005791; GO:0005794; GO:0006914; GO:0007417; GO:0007584; GO:0008152; GO:0008484; GO:0009268; GO:0009986; GO:0010632; GO:0010976; GO:0043627; GO:0046872; GO:0051597; GO:0061580; GO:0070062 0 0 0 PF00884; P50882 CHOYP_RL9.4.6 m.43062 sp RL9_DROME 76.429 140 32 1 1 139 47 186 6.62E-73 219 RL9_DROME reviewed 60S ribosomal protein L9 RpL9 M(2)32D CG6141 Drosophila melanogaster (Fruit fly) 190 centrosome duplication [GO:0051298]; cytoplasmic translation [GO:0002181]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052] GO:0000022; GO:0002181; GO:0003723; GO:0003735; GO:0005840; GO:0007052; GO:0019843; GO:0022625; GO:0051298 0 0 0 PF00347; P52792 CHOYP_GCK.2.2 m.13297 sp HXK4_MOUSE 36.036 111 63 3 16 120 9 117 6.62E-11 61.2 HXK4_MOUSE reviewed Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D) Gck Gk Mus musculus (Mouse) 465 "calcium ion import [GO:0070509]; carbohydrate phosphorylation [GO:0046835]; cellular glucose homeostasis [GO:0001678]; cellular response to glucose starvation [GO:0042149]; detection of glucose [GO:0051594]; endocrine pancreas development [GO:0031018]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycolytic process [GO:0006096]; lipid homeostasis [GO:0055088]; NADP metabolic process [GO:0006739]; negative regulation of epinephrine secretion [GO:0032811]; negative regulation of gluconeogenesis [GO:0045721]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of glycolytic process [GO:0045821]; positive regulation of insulin secretion [GO:0032024]; regulation of insulin secretion [GO:0050796]; regulation of potassium ion transport [GO:0043266]; second-messenger-mediated signaling [GO:0019932]" GO:0000287; GO:0001678; GO:0004340; GO:0004396; GO:0005524; GO:0005536; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0005884; GO:0005978; GO:0006003; GO:0006006; GO:0006096; GO:0006739; GO:0007204; GO:0019932; GO:0030141; GO:0031018; GO:0032024; GO:0032811; GO:0042149; GO:0042593; GO:0043266; GO:0043531; GO:0045180; GO:0045721; GO:0045725; GO:0045821; GO:0046835; GO:0050796; GO:0051594; GO:0055088; GO:0070509 0 0 0 PF00349;PF03727; Q0VFD8 CHOYP_LOC100370656.1.3 m.29984 sp BL1S1_XENTR 67.925 106 34 0 18 123 11 116 6.62E-50 157 BL1S1_XENTR reviewed Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC-1 subunit 1) bloc1s1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 125 aerobic respiration [GO:0009060]; anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; endosomal transport [GO:0016197]; lysosome localization [GO:0032418]; neuron projection development [GO:0031175]; peptidyl-lysine acetylation [GO:0018394] GO:0005739; GO:0005758; GO:0005759; GO:0005829; GO:0008089; GO:0009060; GO:0016197; GO:0018394; GO:0031083; GO:0031175; GO:0032418; GO:0043234; GO:0048490; GO:1904115 0 0 0 PF06320; Q4QR86 CHOYP_BRAFLDRAFT_214790.1.1 m.15955 sp DEPD7_RAT 27.186 526 320 12 44 556 32 507 6.62E-58 204 DEPD7_RAT reviewed DEP domain-containing protein 7 Depdc7 Rattus norvegicus (Rat) 511 intracellular signal transduction [GO:0035556] GO:0005622; GO:0035556 0 0 0 PF00610; Q502M6 CHOYP_TVAG_123950.5.31 m.32615 sp ANR29_DANRE 36.957 184 115 1 9 192 66 248 6.62E-33 122 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5UR67 CHOYP_NAEGRDRAFT_31151.1.1 m.45229 sp RIBX_MIMIV 44.242 165 81 3 329 482 2 166 6.62E-35 131 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q86Y13 CHOYP_NEMVEDRAFT_V1G233709.13.13 m.65966 sp DZIP3_HUMAN 31.707 123 75 4 67 184 451 569 6.62E-07 55.8 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8C627 CHOYP_LOC100368368.1.1 m.61899 sp F221B_MOUSE 52.02 198 91 3 70 265 285 480 6.62E-66 218 F221B_MOUSE reviewed Protein FAM221B Fam221b Mus musculus (Mouse) 487 0 0 0 0 0 PF14753; Q8K0Z9 CHOYP_GPR153.1.1 m.34528 sp GP153_MOUSE 23.669 338 209 15 8 318 14 329 6.62E-12 73.2 GP153_MOUSE reviewed Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1) Gpr153 Pgr1 Mus musculus (Mouse) 631 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q9EQQ9 CHOYP_PHUM_PHUM456250.1.1 m.36632 sp OGA_MOUSE 40.654 214 123 3 3 215 706 916 6.62E-44 159 OGA_MOUSE reviewed Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Bifunctional protein NCOAT) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (EC 3.2.1.52) (N-acetyl-beta-glucosaminidase) Mgea5 Hexc Kiaa0679 Mus musculus (Mouse) 916 glycoprotein metabolic process [GO:0009100]; N-acetylglucosamine metabolic process [GO:0006044]; protein deglycosylation [GO:0006517] GO:0005634; GO:0005829; GO:0006044; GO:0006517; GO:0009100; GO:0016020; GO:0016231 0 0 0 PF07555; Q9WUU7 CHOYP_CATZ.1.1 m.22764 sp CATZ_MOUSE 73.171 82 22 0 101 182 111 192 6.62E-40 140 CATZ_MOUSE reviewed Cathepsin Z (EC 3.4.18.1) Ctsz Mus musculus (Mouse) 306 epithelial tube branching involved in lung morphogenesis [GO:0060441]; proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0005783; GO:0043231; GO:0051603; GO:0060441; GO:0070062 0 0 0 PF00112; Q9WWW2 CHOYP_LOC100643372.1.1 m.64522 sp ALKJ_PSEPU 40.87 575 280 18 38 596 2 532 6.62E-116 359 ALKJ_PSEPU reviewed Alcohol dehydrogenase [acceptor] (EC 1.1.99.-) alkJ Pseudomonas putida (Arthrobacter siderocapsulatus) 552 0 GO:0005886; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; O70277 CHOYP_BRAFLDRAFT_71597.2.3 m.32963 sp TRIM3_RAT 24.227 194 124 7 63 246 557 737 6.63E-06 50.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P19217 CHOYP_ST1A1.1.1 m.49139 sp ST1E1_BOVIN 31.206 282 167 9 53 320 17 285 6.63E-36 134 ST1E1_BOVIN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) 295 estrogen metabolic process [GO:0008210] GO:0004304; GO:0005496; GO:0005737; GO:0008210; GO:0050294 0 0 0 PF00685; P26221 CHOYP_NEMVEDRAFT_V1G83869.1.3 m.3139 sp GUN4_THEFU 50.564 443 194 6 131 554 50 486 6.63E-128 398 GUN4_THEFU reviewed "Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)" celD Thermobifida fusca (Thermomonospora fusca) 880 cellulose catabolic process [GO:0030245] GO:0008810; GO:0030245; GO:0030248 PATHWAY: Glycan metabolism; cellulose degradation. 0 0 PF00553;PF00942;PF00041;PF00759; Q16649 CHOYP_NFIL3.1.1 m.26076 sp NFIL3_HUMAN 55.128 78 35 0 114 191 51 128 6.63E-21 99.4 NFIL3_HUMAN reviewed Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) (Interleukin-3 promoter transcriptional activator) (Interleukin-3-binding protein 1) (Transcriptional activator NF-IL3A) NFIL3 E4BP4 IL3BP1 Homo sapiens (Human) 462 cellular response to interleukin-4 [GO:0071353]; circadian rhythm [GO:0007623]; immune response [GO:0006955]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of gene expression [GO:0010628]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0000977; GO:0000979; GO:0001078; GO:0003677; GO:0003700; GO:0003714; GO:0005634; GO:0006366; GO:0006955; GO:0007623; GO:0010628; GO:0071353 0 0 0 PF07716;PF06529; Q6NWW5 CHOYP_KIF24.1.1 m.9800 sp KIF24_MOUSE 44.318 616 301 9 4 594 5 603 6.63E-149 491 KIF24_MOUSE reviewed Kinesin-like protein KIF24 Kif24 Mus musculus (Mouse) 1356 cilium assembly [GO:0042384]; microtubule-based movement [GO:0007018]; microtubule depolymerization [GO:0007019] GO:0003777; GO:0005524; GO:0005814; GO:0005871; GO:0005874; GO:0007018; GO:0007019; GO:0016887; GO:0042384; GO:0043234 0 0 0 PF00225; Q6ZRF8 CHOYP_LOC100374981.1.16 m.21258 sp RN207_HUMAN 21.359 206 146 7 16 219 103 294 6.63E-09 62 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q6ZRF8 CHOYP_TR12A.1.2 m.32633 sp RN207_HUMAN 20 205 149 6 16 218 103 294 6.63E-08 57.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q9GZR2 CHOYP_REXO4.1.1 m.49550 sp REXO4_HUMAN 51.261 238 94 5 213 437 174 402 6.63E-76 247 REXO4_HUMAN reviewed RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2) REXO4 PMC2 XPMC2H Homo sapiens (Human) 422 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003700; GO:0004527; GO:0005634; GO:0005730; GO:0006355; GO:0044822 0 0 0 PF00929; Q9JLY7 CHOYP_LOAG_05814.1.1 m.56611 sp DUS14_MOUSE 54.491 167 75 1 9 174 27 193 6.63E-60 188 DUS14_MOUSE reviewed Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6) Dusp14 Mkp6 Mus musculus (Mouse) 198 peptidyl-tyrosine dephosphorylation [GO:0035335] GO:0004725; GO:0005634; GO:0005737; GO:0017017; GO:0035335; GO:0044822 0 0 0 PF00782; A1A5K6 CHOYP_contig_015345 m.17869 sp TBC24_XENLA 33.805 565 278 12 226 739 30 549 6.64E-94 306 TBC24_XENLA reviewed TBC1 domain family member 24 tbc1d24 Xenopus laevis (African clawed frog) 562 0 GO:0005096 0 0 0 PF00566;PF07534; A7DTG3 CHOYP_LOC100905019.1.1 m.11802 sp SRTD4_MOUSE 42.5 80 32 2 13 86 78 149 6.64E-08 55.5 SRTD4_MOUSE reviewed SERTA domain-containing protein 4 Sertad4 Mus musculus (Mouse) 377 0 GO:0005634 0 0 0 PF06031; B1AVY7 CHOYP_KI16B.2.3 m.45191 sp KI16B_MOUSE 69.784 278 75 4 1 274 1 273 6.64E-127 393 KI16B_MOUSE reviewed Kinesin-like protein KIF16B Kif16b Kiaa1590 Mus musculus (Mouse) 1312 cytoskeleton-dependent intracellular transport [GO:0030705]; early endosome to late endosome transport [GO:0045022]; endoderm development [GO:0007492]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; formation of primary germ layer [GO:0001704]; Golgi to endosome transport [GO:0006895]; microtubule-based movement [GO:0007018]; receptor catabolic process [GO:0032801]; regulation of receptor recycling [GO:0001919] GO:0001704; GO:0001919; GO:0003777; GO:0005524; GO:0005547; GO:0005768; GO:0005769; GO:0005829; GO:0005871; GO:0005874; GO:0006895; GO:0007018; GO:0007173; GO:0007492; GO:0008543; GO:0008574; GO:0016887; GO:0017137; GO:0030705; GO:0031901; GO:0032266; GO:0032801; GO:0043325; GO:0045022; GO:0080025 0 0 0 PF00498;PF00225;PF00787; O75382 CHOYP_TRIM3.23.58 m.32666 sp TRIM3_HUMAN 26.07 257 164 12 74 315 486 731 6.64E-11 66.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P83425 CHOYP_LOC100373728.1.1 m.59747 sp HIP_MYTED 43.333 60 34 0 62 121 85 144 6.64E-08 53.5 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P86854 CHOYP_ASGR2.4.4 m.62889 sp PLCL_MYTGA 29.801 151 96 5 16 159 9 156 6.64E-21 86.7 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q14162 CHOYP_contig_055866 m.66480 sp SREC_HUMAN 37.079 89 54 2 31 119 252 338 6.64E-12 67 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q3TA38 CHOYP_LOC100882625.1.1 m.25604 sp T120B_MOUSE 58.621 87 36 0 1 87 249 335 6.64E-30 111 T120B_MOUSE reviewed Transmembrane protein 120B Tmem120b Mus musculus (Mouse) 339 fat cell differentiation [GO:0045444]; protein heterooligomerization [GO:0051291] GO:0005637; GO:0016021; GO:0045444; GO:0051291 0 0 0 PF07851; Q6PFY8 CHOYP_BRAFLDRAFT_76030.1.1 m.62778 sp TRI45_MOUSE 22.251 382 246 9 14 357 29 397 6.64E-21 100 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6UXB8 CHOYP_GLIPR1.2.3 m.28541 sp PI16_HUMAN 34.118 170 93 6 48 206 36 197 6.64E-20 97.4 PI16_HUMAN reviewed Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) PI16 CRISP9 PSPBP PSEC0164 UNQ289/PRO328 Homo sapiens (Human) 463 0 GO:0016021; GO:0030414; GO:0070062 0 0 0 PF00188; Q6WRH9 CHOYP_TTN.6.9 m.38119 sp IGS10_RAT 28.8 125 80 4 121 243 2077 2194 6.64E-06 50.8 IGS10_RAT reviewed Immunoglobulin superfamily member 10 (IgSF10) (Calvaria mechanical force protein 608) (CMF608) Igsf10 Cmf608 Rattus norvegicus (Rat) 2597 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; ossification [GO:0001503]; tissue regeneration [GO:0042246] GO:0001503; GO:0005576; GO:0007275; GO:0030154; GO:0042246 0 0 0 PF07679;PF13855; Q7Z3Z2 CHOYP_LOC100375925.1.1 m.8710 sp RD3_HUMAN 31.361 169 108 5 26 189 24 189 6.64E-14 70.5 RD3_HUMAN reviewed Protein RD3 (Retinal degeneration protein 3) RD3 C1orf36 Homo sapiens (Human) 195 response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601] GO:0007601; GO:0050896; GO:0060041 0 0 0 PF14473; Q8BHN5 CHOYP_DPSE_GA12086.1.2 m.9173 sp RBM45_MOUSE 42.342 222 120 4 18 235 22 239 6.64E-50 182 RBM45_MOUSE reviewed RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45) Rbm45 Drb1 Drbp1 Mus musculus (Mouse) 476 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0007399; GO:0030154; GO:0044822 0 0 0 PF00076; Q8N531 CHOYP_CPIPJ_CPIJ004608.1.1 m.23885 sp FBXL6_HUMAN 33.094 417 245 13 85 475 115 523 6.64E-51 184 FBXL6_HUMAN reviewed F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A) FBXL6 FBL6 Homo sapiens (Human) 539 proteolysis [GO:0006508] GO:0004842; GO:0006508 0 0 0 PF12937;PF13516; Q9Y232 CHOYP_LOC101066074.1.1 m.19291 sp CDYL1_HUMAN 35.484 93 49 2 31 112 60 152 6.64E-09 59.7 CDYL1_HUMAN reviewed Chromodomain Y-like protein (CDY-like) (EC 2.3.1.48) CDYL CDYL1 Homo sapiens (Human) 598 "regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003714; GO:0004402; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0007283; GO:0035064 0 0 0 PF00385;PF00378; P20693 CHOYP_contig_020932 m.24093 sp FCER2_MOUSE 33.129 163 84 7 32 192 186 325 6.65E-16 82.4 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; Q01414 CHOYP_FLI1.1.1 m.34177 sp ERG_LYTVA 66.304 92 31 0 204 295 2 93 6.65E-41 147 ERG_LYTVA reviewed Transcriptional regulator ERG homolog (Fragment) ERG Lytechinus variegatus (Green sea urchin) (Variegated urchin) 173 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565 0 0 0 PF00178; Q02858 CHOYP_TIE2.5.6 m.59568 sp TIE2_MOUSE 29.011 455 276 13 799 1228 664 1096 6.65E-45 181 TIE2_MOUSE reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b) Tek Hyk Tie-2 Tie2 Mus musculus (Mouse) 1122 angiogenesis [GO:0001525]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; patterning of blood vessels [GO:0001569]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cytokine secretion involved in immune response [GO:0002741]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of endothelial cell proliferation [GO:0001936]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of NIK/NF-kappaB signaling [GO:1901222]; response to retinoic acid [GO:0032526]; single organismal cell-cell adhesion [GO:0016337]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570] GO:0001525; GO:0001569; GO:0001570; GO:0001934; GO:0001935; GO:0001936; GO:0002040; GO:0002741; GO:0004713; GO:0004714; GO:0004872; GO:0005524; GO:0005576; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007160; GO:0007169; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016021; GO:0016323; GO:0016324; GO:0016337; GO:0016525; GO:0018108; GO:0030097; GO:0030334; GO:0030949; GO:0032526; GO:0032878; GO:0033138; GO:0034446; GO:0042307; GO:0043066; GO:0043552; GO:0045121; GO:0045765; GO:0045766; GO:0045785; GO:0046777; GO:0048014; GO:0048471; GO:0050900; GO:0051259; GO:0051894; GO:0051897; GO:0060347; GO:0070374; GO:1901222; GO:1902533; GO:2000251; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q14162 CHOYP_LOC101160063.1.4 m.2465 sp SREC_HUMAN 35.693 339 188 17 23 349 78 398 6.65E-41 159 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q6P6S4 CHOYP_SIL1.2.2 m.43077 sp SIL1_RAT 37.714 175 103 2 2 174 220 390 6.65E-29 116 SIL1_RAT reviewed Nucleotide exchange factor SIL1 Sil1 Rattus norvegicus (Rat) 465 protein transport [GO:0015031] GO:0005615; GO:0005783; GO:0005788; GO:0015031 0 0 0 0 Q8C6K9 CHOYP_LOC100210247.1.2 m.21459 sp CO6A6_MOUSE 22.979 470 311 18 820 1269 429 867 6.65E-19 97.4 CO6A6_MOUSE reviewed Collagen alpha-6(VI) chain Col6a6 Mus musculus (Mouse) 2265 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; Q8SWR3 CHOYP_LOC100118228.2.3 m.51816 sp SPR_DROME 29.794 339 184 9 61 370 91 404 6.65E-36 139 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q8TDB6 CHOYP_LOC101067833.3.3 m.57834 sp DTX3L_HUMAN 56.667 180 77 1 59 238 561 739 6.65E-66 220 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q96RW7 CHOYP_HMCN1.19.44 m.39500 sp HMCN1_HUMAN 24.008 1562 953 66 1437 2938 1559 2946 6.65E-68 261 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99M80 CHOYP_PTPRA.22.22 m.62460 sp PTPRT_MOUSE 33.647 532 322 6 210 716 765 1290 6.65E-83 293 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ERI6 CHOYP_LOC584740.2.2 m.34291 sp RDH14_MOUSE 32.026 153 99 2 4 156 179 326 6.65E-14 71.2 RDH14_MOUSE reviewed Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) Rdh14 Mus musculus (Mouse) 334 osteoblast differentiation [GO:0001649]; retinol metabolic process [GO:0042572] GO:0001649; GO:0005634; GO:0005739; GO:0005765; GO:0005783; GO:0008106; GO:0016020; GO:0016491; GO:0042572 0 0 0 PF00106; Q9UF56 CHOYP_LOC100369625.1.1 m.56695 sp FXL17_HUMAN 35.638 376 241 1 396 771 321 695 6.65E-71 249 FXL17_HUMAN reviewed F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13) FBXL17 FBL17 FBX13 FBXO13 Homo sapiens (Human) 701 0 0 0 0 0 PF12937;PF13516; A4K526 CHOYP_ISCW_ISCW006146.2.2 m.44758 sp TM256_BUFGR 48.649 111 56 1 76 186 5 114 6.66E-30 108 TM256_BUFGR reviewed Transmembrane protein 256 homolog 0 Bufo gargarizans (Asian toad) (Bufo bufo gargarizans) 114 0 GO:0005886; GO:0016021 0 0 0 PF04241; O13997 CHOYP_CD36_25880.1.1 m.16106 sp YIH1_SCHPO 26.623 154 104 1 185 338 105 249 6.66E-13 71.6 YIH1_SCHPO reviewed Protein IMPACT homolog yih1 SPAC27E2.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 280 cellular response to acidic pH [GO:0071468]; cellular response to amino acid starvation [GO:0034198]; cellular response to benomyl [GO:0072755]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of cell death [GO:0060548]; regulation of cytoplasmic translation in response to stress [GO:1990497] GO:0005634; GO:0005737; GO:0034198; GO:0060548; GO:0070301; GO:0071468; GO:0072755; GO:1990497 0 0 0 PF05773;PF01205; O17320 CHOYP_ACT.13.27 m.39347 sp ACT_CRAGI 99.329 149 1 0 1 149 228 376 6.66E-106 309 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O55076 CHOYP_CDK2.1.1 m.18485 sp CDK2_CRIGR 74.83 294 74 0 34 327 1 294 6.66E-168 471 CDK2_CRIGR reviewed Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) CDK2 CDKN7 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 298 cell division [GO:0051301]; DNA repair [GO:0006281]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067] GO:0004693; GO:0005524; GO:0005768; GO:0005815; GO:0006281; GO:0007067; GO:0015030; GO:0030496; GO:0046872; GO:0051301; GO:0051321 0 0 0 PF00069; O75382 CHOYP_BRAFLDRAFT_87327.9.13 m.42102 sp TRIM3_HUMAN 26.829 123 85 3 121 239 622 743 6.66E-08 58.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P07463 CHOYP_ISCW_ISCW016148.4.6 m.62163 sp CALM_PARTE 63.087 149 55 0 1 149 1 149 6.66E-63 192 CALM_PARTE reviewed Calmodulin (CaM) CAM GSPATT00015825001 Paramecium tetraurelia 149 0 GO:0005509 0 0 0 PF13499; P10090 CHOYP_WHITE.1.1 m.38819 sp WHITE_DROME 46.983 232 120 2 12 240 456 687 6.66E-66 219 WHITE_DROME reviewed Protein white w CG2759 Drosophila melanogaster (Fruit fly) 687 cellular biogenic amine biosynthetic process [GO:0042401]; cGMP transport [GO:0070731]; compound eye pigmentation [GO:0048072]; eye pigment metabolic process [GO:0042441]; eye pigment precursor transport [GO:0006856]; gravitaxis [GO:0042332]; male courtship behavior [GO:0008049]; memory [GO:0007613]; ommochrome biosynthetic process [GO:0006727] GO:0004888; GO:0005524; GO:0005886; GO:0006727; GO:0006856; GO:0007613; GO:0008049; GO:0016021; GO:0031409; GO:0031410; GO:0042332; GO:0042401; GO:0042441; GO:0042626; GO:0048072; GO:0070731 0 0 0 PF01061;PF00005; P10394 CHOYP_LOC100695950.1.6 m.11108 sp POL4_DROME 31.667 900 540 16 1 862 350 1212 6.66E-128 422 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P16621 CHOYP_CNTN1.2.2 m.36867 sp LAR_DROME 22.678 366 242 17 10 354 154 499 6.66E-07 56.2 LAR_DROME reviewed Tyrosine-protein phosphatase Lar (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase) (dLAR) Lar CG10443 Drosophila melanogaster (Fruit fly) 2029 axon extension [GO:0048675]; axon guidance [GO:0007411]; axon target recognition [GO:0007412]; cell adhesion [GO:0007155]; embryonic development via the syncytial blastoderm [GO:0001700]; motor neuron axon guidance [GO:0008045]; negative regulation of homophilic cell adhesion [GO:1903386]; nervous system development [GO:0007399]; oogenesis [GO:0048477]; photoreceptor cell morphogenesis [GO:0008594]; protein dephosphorylation [GO:0006470]; R7 cell development [GO:0045467]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell shape [GO:0008360]; retinal ganglion cell axon guidance [GO:0031290]; spermatogenesis [GO:0007283]; synaptic growth at neuromuscular junction [GO:0051124] GO:0001700; GO:0004725; GO:0005001; GO:0005875; GO:0005886; GO:0005925; GO:0006470; GO:0007155; GO:0007283; GO:0007399; GO:0007411; GO:0007412; GO:0008045; GO:0008201; GO:0008360; GO:0008594; GO:0016021; GO:0030424; GO:0031290; GO:0032093; GO:0045467; GO:0048477; GO:0048675; GO:0048841; GO:0051124; GO:1903386 0 0 0 PF00041;PF07679;PF00102; P26150 CHOYP_LOC100370123.1.1 m.52165 sp 3BHS3_MOUSE 32.955 352 217 11 6 344 8 353 6.66E-47 166 3BHS3_MOUSE reviewed 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type III) (3-beta-HSD III) [Includes: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC 1.1.1.145) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase); Steroid Delta-isomerase (EC 5.3.3.1) (Delta-5-3-ketosteroid isomerase)] Hsd3b3 Mus musculus (Mouse) 373 steroid biosynthetic process [GO:0006694] GO:0003854; GO:0004769; GO:0005743; GO:0005758; GO:0005789; GO:0006694; GO:0016021 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF01073; P40983 CHOYP_TRIADDRAFT_54952.1.2 m.5517 sp YOR6_CALSR 26.809 235 134 7 34 262 16 218 6.66E-10 65.1 YOR6_CALSR reviewed Uncharacterized protein in xynA 3'region (ORF6) (Fragment) 0 Caldicellulosiruptor sp. (strain Rt8B.4) 402 0 0 0 0 0 PF00350; P97449 CHOYP_LOC574617.1.1 m.1015 sp AMPN_MOUSE 49.216 319 155 3 1 312 212 530 6.66E-105 330 AMPN_MOUSE reviewed Aminopeptidase N (AP-N) (mAPN) (EC 3.4.11.2) (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Membrane protein p161) (Microsomal aminopeptidase) (CD antigen CD13) Anpep Lap-1 Lap1 Mus musculus (Mouse) 966 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cellular aromatic compound metabolic process [GO:0006725]; negative regulation of renal sodium excretion [GO:0035814]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0001525; GO:0005615; GO:0005737; GO:0005765; GO:0005793; GO:0006508; GO:0006725; GO:0008270; GO:0009897; GO:0012506; GO:0016021; GO:0030154; GO:0031983; GO:0035814; GO:0042277; GO:0043171; GO:0070006; GO:0070062 0 0 0 PF11838;PF01433; Q06852 CHOYP_LRP4.4.5 m.46038 sp SLAP1_CLOTH 56.034 232 53 18 752 935 1541 1771 6.66E-19 97.4 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q14CW9 CHOYP_AT7L3.1.2 m.4785 sp AT7L3_HUMAN 49.835 303 139 8 46 341 17 313 6.66E-75 238 AT7L3_HUMAN reviewed Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog) ATXN7L3 Homo sapiens (Human) 347 "histone deubiquitination [GO:0016578]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000124; GO:0003713; GO:0006351; GO:0008270; GO:0016578; GO:0030374; GO:0045893; GO:0071819 0 0 0 PF08313;PF08209; Q1HPL8 CHOYP_TSP_01008.3.3 m.57605 sp NDUBA_BOMMO 38.889 126 75 1 63 188 27 150 6.66E-26 100 NDUBA_BOMMO reviewed NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0 Bombyx mori (Silk moth) 159 oxidation-reduction process [GO:0055114] GO:0005743; GO:0055114; GO:0070469 0 0 0 PF10249; Q5BJS9 CHOYP_MBLK1.1.1 m.51933 sp MORN4_RAT 59.712 139 56 0 2 140 5 143 6.66E-57 177 MORN4_RAT reviewed MORN repeat-containing protein 4 Morn4 Rattus norvegicus (Rat) 146 0 0 0 0 0 PF02493; Q8I7P9 CHOYP_CRE_30767.2.2 m.58116 sp POL5_DROME 31.395 172 113 3 41 210 162 330 6.66E-12 70.5 POL5_DROME reviewed Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1003 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003676; GO:0003964; GO:0004519; GO:0005634; GO:0006313; GO:0008233; GO:0015074 0 0 0 PF00665;PF00078; Q91ZW9 CHOYP_BRAFLDRAFT_117282.4.6 m.21640 sp C209C_MOUSE 37.209 129 75 5 26 152 48 172 6.66E-18 87.4 C209C_MOUSE reviewed CD209 antigen-like protein C (DC-SIGN-related protein 2) (DC-SIGNR2) (CD antigen CD209) Cd209c Mus musculus (Mouse) 178 0 GO:0005537; GO:0046872 0 0 0 PF00059; Q99471 CHOYP_LOC101064793.1.1 m.27191 sp PFD5_HUMAN 51.634 153 74 0 21 173 2 154 6.66E-52 166 PFD5_HUMAN reviewed Prefoldin subunit 5 (C-Myc-binding protein Mm-1) (Myc modulator 1) PFDN5 MM1 PFD5 Homo sapiens (Human) 154 "negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of transcription, DNA-templated [GO:0045892]; protein folding [GO:0006457]; regulation of transcription, DNA-templated [GO:0006355]; retina development in camera-type eye [GO:0060041]" GO:0003714; GO:0005634; GO:0005737; GO:0006355; GO:0006457; GO:0016272; GO:0045892; GO:0060041; GO:0090090 0 0 0 PF02996; Q9NRA1 CHOYP_MGC64292.1.1 m.47725 sp PDGFC_HUMAN 31.008 129 80 6 35 155 55 182 6.66E-07 54.3 PDGFC_HUMAN reviewed "Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]" PDGFC SCDGF UNQ174/PRO200 Homo sapiens (Human) 345 activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; blood coagulation [GO:0007596]; bone development [GO:0060348]; cellular response to amino acid stimulus [GO:0071230]; central nervous system development [GO:0007417]; digestive tract development [GO:0048565]; embryo development [GO:0009790]; organ morphogenesis [GO:0009887]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of DNA replication [GO:0045740]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein autophosphorylation [GO:0031954]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730] GO:0000139; GO:0005161; GO:0005576; GO:0005615; GO:0005634; GO:0005737; GO:0005788; GO:0005829; GO:0005886; GO:0007171; GO:0007417; GO:0007596; GO:0009790; GO:0009887; GO:0009986; GO:0014068; GO:0030335; GO:0031954; GO:0042803; GO:0043406; GO:0045740; GO:0048008; GO:0048146; GO:0048565; GO:0050730; GO:0051781; GO:0060348; GO:0070062; GO:0070374; GO:0071230 0 0 0 PF00431;PF00341; Q9QZK7 CHOYP_BRAFLDRAFT_92727.2.17 m.3649 sp DOK3_MOUSE 35.484 93 57 2 208 300 150 239 6.66E-10 63.5 DOK3_MOUSE reviewed Docking protein 3 (Downstream of tyrosine kinase 3) (p62(dok)-like protein) (DOK-L) Dok3 Dokl Mus musculus (Mouse) 444 Ras protein signal transduction [GO:0007265] GO:0005737; GO:0005886; GO:0007265 0 0 0 PF02174; Q9W735 CHOYP_PRM1A.1.2 m.3038 sp PRM1A_DANRE 24.213 826 511 28 18 738 10 825 6.66E-50 191 PRM1A_DANRE reviewed Prominin-1-A (Prominin-like protein 1) prom1a proml1 Danio rerio (Zebrafish) (Brachydanio rerio) 826 0 GO:0005783; GO:0005793; GO:0005886; GO:0016021; GO:0016324; GO:0031528 0 0 0 PF05478; Q9Z0R9 CHOYP_FADS2.1.2 m.6699 sp FADS2_MOUSE 55.53 443 182 3 1 428 1 443 6.66E-180 512 FADS2_MOUSE reviewed Fatty acid desaturase 2 (EC 1.14.19.-) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) Fads2 Fadsd2 Mus musculus (Mouse) 444 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005789; GO:0006636; GO:0016020; GO:0016021 PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. 0 0 PF00173;PF00487; A5YM72 CHOYP_PCKG.1.2 m.43786 sp CRNS1_HUMAN 45.981 311 157 3 1 310 409 709 6.67E-89 285 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 A7SMW7 CHOYP_RS13.2.5 m.20382 sp L2HDH_NEMVE 60.215 93 26 2 77 163 211 298 6.67E-30 115 L2HDH_NEMVE reviewed "L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2)" v1g172254 Nematostella vectensis (Starlet sea anemone) 456 0 GO:0005739; GO:0047545 0 0 0 PF01266; H3BS89 CHOYP_LOC100118354.1.4 m.27048 sp T178B_HUMAN 20.863 278 149 8 7 222 4 272 6.67E-07 53.1 T178B_HUMAN reviewed Transmembrane protein 178B TMEM178B Homo sapiens (Human) 294 0 GO:0016021 0 0 0 PF13903; P10041 CHOYP_LOC575161.3.5 m.25909 sp DL_DROME 34.934 229 135 3 168 394 452 668 6.67E-33 135 DL_DROME reviewed Neurogenic locus protein delta Dl CG3619 Drosophila melanogaster (Fruit fly) 833 "actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; asymmetric cell division [GO:0008356]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye retinal cell programmed cell death [GO:0046667]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; ectoderm development [GO:0007398]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; germ-line stem cell population maintenance [GO:0030718]; glial cell migration [GO:0008347]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; R3/R4 cell fate commitment [GO:0007464]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of R8 cell spacing in compound eye [GO:0045468]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]; stem cell differentiation [GO:0048863]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]" GO:0001708; GO:0001736; GO:0005102; GO:0005112; GO:0005509; GO:0005768; GO:0005886; GO:0005912; GO:0007015; GO:0007155; GO:0007219; GO:0007298; GO:0007314; GO:0007398; GO:0007399; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007451; GO:0007460; GO:0007464; GO:0007474; GO:0007475; GO:0007476; GO:0007480; GO:0007498; GO:0008284; GO:0008347; GO:0008356; GO:0008407; GO:0008586; GO:0009986; GO:0016021; GO:0016318; GO:0016330; GO:0019233; GO:0030139; GO:0030431; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0031410; GO:0035003; GO:0035155; GO:0035157; GO:0036011; GO:0042067; GO:0042676; GO:0045465; GO:0045468; GO:0045931; GO:0046331; GO:0046667; GO:0048190; GO:0048477; GO:0048749; GO:0048800; GO:0048863; GO:0050768 0 0 0 PF01414;PF00008;PF12661;PF07657; P17133 CHOYP_AAEL_AAEL015585.3.3 m.37808 sp RU17_DROME 65.19 158 55 0 1 158 1 158 6.67E-61 197 RU17_DROME reviewed U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70) snRNP-U1-70K snRNP27D snRNP70K CG8749 Drosophila melanogaster (Fruit fly) 448 "mitotic spindle organization [GO:0007052]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; neurogenesis [GO:0022008]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]" GO:0000166; GO:0000243; GO:0000381; GO:0000398; GO:0003723; GO:0003729; GO:0005634; GO:0005681; GO:0005685; GO:0007052; GO:0016607; GO:0022008; GO:0030619; GO:0043484; GO:0048025; GO:0071004; GO:0071011; GO:0071013 0 0 0 PF00076;PF12220; P48159 CHOYP_RL23.4.11 m.13925 sp RL23_DROME 92.143 140 11 0 1 140 1 140 6.67E-91 262 RL23_DROME reviewed 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) 140 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0006412; GO:0007052; GO:0017022; GO:0022008; GO:0022625; GO:0070180 0 0 0 PF00238; P48159 CHOYP_RL23.8.11 m.40909 sp RL23_DROME 92.143 140 11 0 1 140 1 140 6.67E-91 262 RL23_DROME reviewed 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) 140 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0006412; GO:0007052; GO:0017022; GO:0022008; GO:0022625; GO:0070180 0 0 0 PF00238; P86789 CHOYP_BRAFLDRAFT_76885.1.1 m.20259 sp GIGA6_CRAGI 34.783 276 163 9 8 277 12 276 6.67E-35 136 GIGA6_CRAGI reviewed Gigasin-6 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 302 0 GO:0016021 0 0 0 PF00144; Q01460 CHOYP_LOC100371430.1.1 m.61181 sp DIAC_RAT 41.228 342 193 5 33 370 26 363 6.67E-98 298 DIAC_RAT reviewed Di-N-acetylchitobiase (EC 3.2.1.-) Ctbs Ctb Rattus norvegicus (Rat) 367 chitin catabolic process [GO:0006032]; oligosaccharide catabolic process [GO:0009313] GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0006032; GO:0008061; GO:0009313; GO:0016798; GO:0070062 0 0 0 PF00704; Q6PGE4 CHOYP_LOC100017222.1.1 m.19930 sp ZF316_MOUSE 34.222 225 136 8 517 734 733 952 6.67E-26 119 ZF316_MOUSE reviewed Zinc finger protein 316 Znf316 Zfp316 Mus musculus (Mouse) 1016 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q6ZRF8 CHOYP_TR12A.2.2 m.60866 sp RN207_HUMAN 22.488 209 139 9 6 208 103 294 6.67E-08 57.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8N2S1 CHOYP_BRAFLDRAFT_98740.3.7 m.46571 sp LTBP4_HUMAN 35.714 476 244 27 22 457 665 1118 6.67E-48 184 LTBP4_HUMAN reviewed Latent-transforming growth factor beta-binding protein 4 (LTBP-4) LTBP4 Homo sapiens (Human) 1624 growth hormone secretion [GO:0030252]; multicellular organism development [GO:0007275]; protein folding [GO:0006457]; regulation of cell differentiation [GO:0045595]; regulation of cell growth [GO:0001558]; regulation of proteolysis [GO:0030162]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015] GO:0001558; GO:0005024; GO:0005178; GO:0005509; GO:0005539; GO:0005576; GO:0005578; GO:0005615; GO:0006457; GO:0007275; GO:0017015; GO:0030162; GO:0030252; GO:0031012; GO:0045595; GO:0050431; GO:0070062 0 0 0 PF07645;PF00683; Q8R173 CHOYP_BRAFLDRAFT_218835.2.2 m.19333 sp ZDHC3_MOUSE 64.143 251 89 1 81 330 36 286 6.67E-117 343 ZDHC3_MOUSE reviewed Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (GABA-A receptor-associated membrane protein 1) (Golgi-specific DHHC zinc finger protein) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) Zdhhc3 Godz Gramp1 Mus musculus (Mouse) 299 protein palmitoylation [GO:0018345]; protein targeting [GO:0006605] GO:0000139; GO:0005794; GO:0006605; GO:0008270; GO:0016020; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q92851 CHOYP_LOC795066.3.3 m.51729 sp CASPA_HUMAN 36.232 138 69 6 14 147 280 402 6.67E-14 77.8 CASPA_HUMAN reviewed Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005829; GO:0006915; GO:0007166; GO:0008625; GO:0030225; GO:0031265; GO:0031625; GO:0035877; GO:0042981; GO:0043123; GO:0097190; GO:0097199; GO:0097342 0 0 0 PF01335; Q9BVR0 CHOYP_LOC100370069.14.14 m.62599 sp HRC23_HUMAN 45.946 74 35 2 294 365 590 660 6.67E-11 68.6 HRC23_HUMAN reviewed Putative HERC2-like protein 3 HERC2P3 Homo sapiens (Human) 1158 0 GO:0004842; GO:0046872 0 0 0 PF06701; Q9DBB9 CHOYP_ALS.1.1 m.48111 sp CPN2_MOUSE 30.864 405 252 8 151 546 50 435 6.67E-30 127 CPN2_MOUSE reviewed Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) Cpn2 Mus musculus (Mouse) 547 0 GO:0070062; GO:0072562 0 0 0 PF13855; Q9JMD3 CHOYP_BRAFLDRAFT_117216.1.1 m.25201 sp PCTL_MOUSE 46 250 133 2 6 254 22 270 6.67E-79 243 PCTL_MOUSE reviewed PCTP-like protein (PCTP-L) (START domain-containing protein 10) (StARD10) (Serologically defined colon cancer antigen 28 homolog) (StAR-related lipid transfer protein 10) Stard10 Pctpl Sdccag28 Sdccagg28 Mus musculus (Mouse) 291 bile acid secretion [GO:0032782]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360] GO:0005829; GO:0005902; GO:0008289; GO:0016020; GO:0031514; GO:0032782; GO:0035360; GO:0046581 0 0 0 PF01852; D2GXS7 CHOYP_BRAFLDRAFT_102380.7.11 m.47299 sp TRIM2_AILME 24.893 233 158 8 43 263 488 715 6.68E-10 62.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P21548 CHOYP_LOC762549.2.2 m.56646 sp GBRG2_CHICK 24.286 280 183 11 5 267 77 344 6.68E-13 73.2 GBRG2_CHICK reviewed Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2) GABRG2 Gallus gallus (Chicken) 474 adult behavior [GO:0030534]; cellular response to histamine [GO:0071420]; chemical synaptic transmission [GO:0007268]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; post-embryonic development [GO:0009791] GO:0004890; GO:0005230; GO:0005254; GO:0005887; GO:0007214; GO:0007268; GO:0009791; GO:0030054; GO:0030424; GO:0030534; GO:0034707; GO:0045211; GO:0071420; GO:1902476; GO:1902711 0 0 0 PF02931;PF02932; P90703 CHOYP_LOC100175959.1.7 m.1896 sp RLA2_BRUMA 47.788 113 58 1 1 112 2 114 6.68E-30 106 RLA2_BRUMA reviewed 60S acidic ribosomal protein P2 rpp-2 Brugia malayi (Filarial nematode worm) 114 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 P90703 CHOYP_RLA2.4.9 m.15347 sp RLA2_BRUMA 47.788 113 58 1 1 112 2 114 6.68E-30 106 RLA2_BRUMA reviewed 60S acidic ribosomal protein P2 rpp-2 Brugia malayi (Filarial nematode worm) 114 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 Q08353 CHOYP_DYAK_CACT.1.1 m.58631 sp IKBA_PIG 36.15 213 130 4 1 212 80 287 6.68E-33 123 IKBA_PIG reviewed NF-kappa-B inhibitor alpha (ECI-6) (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) NFKBIA IKBA Sus scrofa (Pig) 314 "cytoplasmic sequestering of NF-kappaB [GO:0007253]; cytoplasmic sequestering of transcription factor [GO:0042994]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage derived foam cell differentiation [GO:0010745]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070427]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; positive regulation of cellular protein metabolic process [GO:0032270]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein import into nucleus, translocation [GO:0000060]; regulation of cell proliferation [GO:0042127]; response to exogenous dsRNA [GO:0043330]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; response to muscle stretch [GO:0035994]; toll-like receptor 4 signaling pathway [GO:0034142]" GO:0000060; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0007253; GO:0008139; GO:0010745; GO:0010875; GO:0010888; GO:0031625; GO:0031663; GO:0032088; GO:0032270; GO:0032495; GO:0032496; GO:0034142; GO:0035994; GO:0042127; GO:0042994; GO:0043330; GO:0045638; GO:0045746; GO:0045944; GO:0051059; GO:0070427; GO:0070431 0 0 0 PF00023;PF12796; Q13231 CHOYP_CHIT1.2.3 m.9727 sp CHIT1_HUMAN 47.452 314 160 3 1 314 78 386 6.68E-97 306 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q26636 CHOYP_LOC100907841.1.1 m.39986 sp CATL_SARPE 48.553 311 153 2 53 356 25 335 6.68E-99 299 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q3MII6 CHOYP_LOC100678410.1.1 m.16114 sp TBC25_HUMAN 50.243 412 191 5 20 423 41 446 6.68E-142 437 TBC25_HUMAN reviewed TBC1 domain family member 25 TBC1D25 OATL1 Homo sapiens (Human) 688 activation of GTPase activity [GO:0090630]; autophagy [GO:0006914]; intracellular protein transport [GO:0006886]; regulation of autophagosome maturation [GO:1901096]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005776; GO:0006886; GO:0006914; GO:0012505; GO:0017137; GO:0031338; GO:0031410; GO:0090630; GO:1901096 0 0 0 PF00566; Q5RJ80 CHOYP_LOC100701854.1.6 m.5954 sp CAPR2_DANRE 33.835 133 78 5 290 417 784 911 6.68E-12 71.2 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q6ZQY2 CHOYP_LOC581313.1.2 m.9778 sp LR74B_HUMAN 30.645 186 117 5 196 376 133 311 6.68E-10 65.9 LR74B_HUMAN reviewed Leucine-rich repeat-containing protein 74B LRRC74B Homo sapiens (Human) 392 0 0 0 0 0 PF13516; Q9N2N6 CHOYP_LOC373275.5.7 m.49535 sp TBB_EUPFO 60.177 113 20 3 1 101 1 100 6.68E-36 130 TBB_EUPFO reviewed Tubulin beta chain (Beta-tubulin) 0 Euplotes focardii 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; A4IF63 CHOYP_LOC100372342.1.1 m.63403 sp TRIM2_BOVIN 30.508 118 76 3 174 285 622 739 6.69E-07 53.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6H8H2 CHOYP_DEN4C.1.1 m.3342 sp DEN4C_MOUSE 58.273 139 56 1 5 141 8 146 6.69E-47 165 DEN4C_MOUSE reviewed DENN domain-containing protein 4C Dennd4c Mus musculus (Mouse) 1906 cellular response to insulin stimulus [GO:0032869]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031] GO:0005829; GO:0005886; GO:0015031; GO:0017112; GO:0030659; GO:0030904; GO:0032593; GO:0032869; GO:0072659 0 0 0 PF03455;PF02141;PF03456; A8DZE7 CHOYP_D42E1.2.2 m.12750 sp D42E1_DANRE 56.022 357 148 4 1 350 7 361 6.69E-143 413 D42E1_DANRE reviewed Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) sdr42e1 si:ch211-79l17.4 zgc:123280 Danio rerio (Zebrafish) (Brachydanio rerio) 387 steroid biosynthetic process [GO:0006694] GO:0003854; GO:0006694; GO:0016021 0 0 0 PF01073; B4F6Q9 CHOYP_OXR1.1.1 m.63467 sp OXR1_XENLA 36.145 166 89 6 79 242 64 214 6.69E-13 72 OXR1_XENLA reviewed Oxidation resistance protein 1 oxr1 Xenopus laevis (African clawed frog) 857 0 GO:0005739 0 0 0 PF01476;PF07534; E1BD59 CHOYP_BRAFLDRAFT_82869.3.6 m.48445 sp TRI56_BOVIN 36.596 235 131 6 23 245 13 241 6.69E-39 146 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O01393 CHOYP_LOC100533356.2.6 m.12534 sp UNC9_CAEEL 32.959 267 172 2 1 266 1 261 6.69E-54 183 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O70273 CHOYP_LOC100375405.1.1 m.48388 sp EHF_MOUSE 44.444 99 51 2 170 266 200 296 6.69E-20 90.1 EHF_MOUSE reviewed ETS homologous factor (ETS domain-containing transcription factor) Ehf Mus musculus (Mouse) 300 "cell differentiation [GO:0030154]; epithelial cell differentiation [GO:0030855]; epithelial cell proliferation [GO:0050673]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]" GO:0000978; GO:0000981; GO:0001077; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005794; GO:0006357; GO:0030154; GO:0030855; GO:0045893; GO:0045944; GO:0050673 0 0 0 PF00178;PF02198; P12001 CHOYP_HSP70-3.1.1 m.19151 sp RL18_RAT 74.332 187 48 0 51 237 1 187 6.69E-95 278 RL18_RAT reviewed 60S ribosomal protein L18 Rpl18 Rattus norvegicus (Rat) 188 liver regeneration [GO:0097421]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0097421 0 0 0 PF17135; P16423 CHOYP_LOC100561123.26.28 m.57594 sp POLR_DROME 30.769 156 99 4 16 164 512 665 6.69E-09 61.2 POLR_DROME reviewed Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1057 0 GO:0003964; GO:0004190; GO:0004519; GO:0046872 0 0 0 PF00078; P48159 CHOYP_BRAFLDRAFT_73285.2.2 m.12826 sp RL23_DROME 91.429 140 12 0 23 162 1 140 6.69E-90 261 RL23_DROME reviewed 60S ribosomal protein L23 (L17A) RpL23 RpL17A CG3661 Drosophila melanogaster (Fruit fly) 140 mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0006412; GO:0007052; GO:0017022; GO:0022008; GO:0022625; GO:0070180 0 0 0 PF00238; Q09575 CHOYP_contig_042555 m.49029 sp YRD6_CAEEL 27.402 281 185 6 1 270 816 1088 6.69E-24 105 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q2M2T9 CHOYP_ISCW_ISCW010143.3.3 m.61540 sp TERB2_BOVIN 26.728 217 125 5 6 207 1 198 6.69E-14 71.2 TERB2_BOVIN reviewed Telomere repeats-binding bouquet formation protein 2 TERB2 Bos taurus (Bovine) 221 meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]; synapsis [GO:0007129] GO:0000784; GO:0005637; GO:0007129; GO:0045141; GO:0070197 0 0 0 PF15101; Q502M6 CHOYP_TVAG_123950.22.31 m.54137 sp ANR29_DANRE 42.478 113 65 0 1 113 116 228 6.69E-21 87.8 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q55E58 CHOYP_NEMVEDRAFT_V1G199564.5.6 m.59960 sp PATS1_DICDI 23.242 327 208 10 512 827 1793 2087 6.69E-13 77.8 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5EA92 CHOYP_BRAFLDRAFT_124346.2.2 m.29169 sp AL14E_BOVIN 50.42 119 49 4 27 140 141 254 6.69E-32 117 AL14E_BOVIN reviewed ARL14 effector protein (ARF7 effector protein) ARL14EP ARF7EP Bos taurus (Bovine) 260 0 GO:0005737 0 0 0 PF14949; Q5RDC1 CHOYP_BRAFLDRAFT_118099.5.6 m.41337 sp FAM21_PONAB 32.924 1221 546 47 29 1153 18 1061 6.69E-85 309 FAM21_PONAB reviewed WASH complex subunit FAM21 FAM21 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1340 "retrograde transport, endosome to Golgi [GO:0042147]" GO:0005769; GO:0005829; GO:0005886; GO:0031901; GO:0042147; GO:0071203 0 0 0 PF15255; Q5SSG5 CHOYP_LOC661889.1.1 m.48910 sp RSLAB_MOUSE 52.525 198 92 1 15 210 6 203 6.69E-74 224 RSLAB_MOUSE reviewed Ras-like protein family member 10B Rasl10b Mus musculus (Mouse) 203 positive regulation of peptide hormone secretion [GO:0090277]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050]; small GTPase mediated signal transduction [GO:0007264] GO:0003050; GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0090277 0 0 0 PF00071; Q5ZLY5 CHOYP_DANA_GF20914.1.1 m.14747 sp PKHF2_CHICK 65.753 219 74 1 1 219 1 218 6.69E-110 320 PKHF2_CHICK reviewed Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) PLEKHF2 RCJMB04_4g10 Gallus gallus (Chicken) 249 protein transport [GO:0015031] GO:0005783; GO:0015031; GO:0031901; GO:0046872 0 0 0 PF01363;PF00169; Q6PG95 CHOYP_LOC100888549.1.1 m.38579 sp CRML_MOUSE 40.938 320 165 7 115 416 155 468 6.69E-72 263 CRML_MOUSE reviewed Protein cramped-like (Cramped chromatin regulator homolog 1) (Hematological and neurological expressed 1-like protein) Cramp1 Cramp1l Hn1l Kiaa1426 Tce4 Mus musculus (Mouse) 1285 0 GO:0003677; GO:0003682; GO:0005634 0 0 0 0 Q80ZF0 CHOYP_COBA1.1.1 m.63080 sp CORA1_RAT 52.857 70 27 1 5 74 1361 1424 6.69E-10 60.5 CORA1_RAT reviewed Collagen alpha-1(XXVII) chain Col27a1 Rattus norvegicus (Rat) 1855 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte development [GO:0003431] GO:0003431; GO:0005201; GO:0005583; GO:0030198; GO:0046872 0 0 0 PF01410;PF01391; Q8IWZ3 CHOYP_LOC581927.26.27 m.63964 sp ANKH1_HUMAN 32.965 452 280 14 11 444 242 688 6.69E-52 192 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q95SX7 CHOYP_LOC100561123.21.28 m.43379 sp RTBS_DROME 28.842 423 256 13 89 487 416 817 6.69E-37 152 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q99020 CHOYP_LOC100371985.2.3 m.42479 sp ROAA_MOUSE 60.544 147 57 1 112 258 70 215 6.69E-54 179 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q9NYT6 CHOYP_LOC100943466.1.1 m.19735 sp ZN226_HUMAN 38.191 199 111 3 312 504 362 554 6.69E-37 149 ZN226_HUMAN reviewed Zinc finger protein 226 ZNF226 Homo sapiens (Human) 803 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q9R087 CHOYP_GPC6.1.1 m.64926 sp GPC6_MOUSE 47.094 499 224 4 33 530 29 488 6.69E-167 493 GPC6_MOUSE reviewed Glypican-6 [Cleaved into: Secreted glypican-6] Gpc6 Mus musculus (Mouse) 555 cell migration [GO:0016477]; glycosaminoglycan biosynthetic process [GO:0006024] GO:0005578; GO:0005615; GO:0005634; GO:0005796; GO:0005887; GO:0006024; GO:0016477; GO:0031225; GO:0043395 0 0 0 PF01153; A1ZA47 CHOYP_AGAP_AGAP006260.1.1 m.50433 sp ZASP_DROME 41.304 92 50 3 2 91 6 95 6.70E-10 66.2 ZASP_DROME reviewed PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) 2194 muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952] GO:0001725; GO:0001952; GO:0003779; GO:0005915; GO:0005925; GO:0005927; GO:0008270; GO:0015629; GO:0016323; GO:0030018; GO:0030239; GO:0031252; GO:0045177; GO:0045178; GO:0051371; GO:0061061 0 0 0 PF15936;PF00412;PF00595; A4IF63 CHOYP_BRAFLDRAFT_241726.22.22 m.52736 sp TRIM2_BOVIN 27.778 126 86 3 25 149 622 743 6.70E-10 60.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5PJA1 CHOYP_TAF9.1.1 m.10395 sp KAD6_BOVIN 67.665 167 54 0 25 191 4 170 6.70E-86 253 KAD6_BOVIN reviewed Adenylate kinase isoenzyme 6 (AK6) (EC 2.7.4.3) (Coilin-interacting nuclear ATPase protein) (Dual activity adenylate kinase/ATPase) (AK/ATPase) AK6 CINAP Bos taurus (Bovine) 172 0 GO:0004017; GO:0005524; GO:0005654; GO:0015030; GO:0016020; GO:0016887 0 0 0 0 P18433 CHOYP_LOC100208023.1.8 m.8628 sp PTPRA_HUMAN 26.759 725 434 19 551 1232 130 800 6.70E-73 263 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P46939 CHOYP_LOC100876889.1.1 m.9818 sp UTRO_HUMAN 60.169 236 93 1 17 252 22 256 6.70E-90 294 UTRO_HUMAN reviewed Utrophin (Dystrophin-related protein 1) (DRP-1) UTRN DMDL DRP1 Homo sapiens (Human) 3433 muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649] GO:0001954; GO:0003779; GO:0005178; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0006936; GO:0007517; GO:0007528; GO:0008270; GO:0016010; GO:0016020; GO:0017166; GO:0019901; GO:0030054; GO:0030175; GO:0030426; GO:0030864; GO:0031527; GO:0031594; GO:0042383; GO:0043234; GO:0045211; GO:0070062; GO:2000649 0 0 0 PF00307;PF09068;PF09069;PF00435;PF00569; P49337 CHOYP_WNT4.1.1 m.11965 sp WNT4_CHICK 62 350 129 2 9 358 6 351 6.70E-160 454 WNT4_CHICK reviewed Protein Wnt-4 WNT4 WNT-4 Gallus gallus (Chicken) 351 "adrenal gland development [GO:0030325]; androgen biosynthetic process [GO:0006702]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic epithelial tube formation [GO:0001838]; epithelial to mesenchymal transition [GO:0001837]; establishment of protein localization to plasma membrane [GO:0090002]; female gonad development [GO:0008585]; female sex determination [GO:0030237]; immature T cell proliferation in thymus [GO:0033080]; kidney morphogenesis [GO:0060993]; liver development [GO:0001889]; male gonad development [GO:0008584]; mesenchymal to epithelial transition [GO:0060231]; metanephric nephron morphogenesis [GO:0072273]; metanephric tubule formation [GO:0072174]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of male gonad development [GO:2000019]; negative regulation of testicular blood vessel morphogenesis [GO:0061369]; negative regulation of testosterone biosynthetic process [GO:2000225]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of wound healing [GO:0061045]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway via MAPK cascade [GO:0038030]; oocyte development [GO:0048599]; paramesonephric duct development [GO:0061205]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cartilage development [GO:0061036]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cortisol biosynthetic process [GO:2000066]; positive regulation of dermatome development [GO:0061184]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of skeletal muscle cell proliferation [GO:0014858]; positive regulation of skeletal muscle fiber differentiation [GO:1902811]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell-cell adhesion [GO:0022407]; renal vesicle formation [GO:0072033]; renal vesicle induction [GO:0072034]; smooth muscle cell differentiation [GO:0051145]; somatotropin secreting cell differentiation [GO:0060126]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; Wnt signaling pathway [GO:0016055]" GO:0001658; GO:0001837; GO:0001838; GO:0001889; GO:0003714; GO:0005109; GO:0005578; GO:0005615; GO:0005737; GO:0006702; GO:0008584; GO:0008585; GO:0009267; GO:0009986; GO:0014858; GO:0016055; GO:0022407; GO:0030182; GO:0030237; GO:0030325; GO:0030336; GO:0030501; GO:0032349; GO:0032967; GO:0033080; GO:0038030; GO:0040037; GO:0043547; GO:0045165; GO:0045596; GO:0045669; GO:0045836; GO:0045892; GO:0045893; GO:0048599; GO:0051145; GO:0051496; GO:0051894; GO:0060070; GO:0060126; GO:0060129; GO:0060231; GO:0060993; GO:0061036; GO:0061045; GO:0061184; GO:0061205; GO:0061369; GO:0071560; GO:0072033; GO:0072034; GO:0072174; GO:0072273; GO:0090002; GO:0090090; GO:0090263; GO:1902811; GO:2000019; GO:2000066; GO:2000225; GO:2001234 0 0 0 PF00110; P52842 CHOYP_SULT2A1.1.1 m.24012 sp ST2A1_MACFA 33.451 284 167 10 20 291 8 281 6.70E-36 133 ST2A1_MACFA reviewed Bile salt sulfotransferase (EC 2.8.2.14) (Hydroxysteroid sulfotransferase) (HST) (Sulfotransferase 2A1) (ST2A1) SULT2A1 STD Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 285 bile acid catabolic process [GO:0030573] GO:0005737; GO:0030573; GO:0047704 0 0 0 PF00685; Q09326 CHOYP_LOC101165022.1.1 m.9056 sp MGAT2_RAT 45.706 361 192 4 97 455 80 438 6.70E-124 370 MGAT2_RAT reviewed "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II)" Mgat2 Gnt2 Rattus norvegicus (Rat) 442 oligosaccharide biosynthetic process [GO:0009312]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279] GO:0000139; GO:0005795; GO:0006487; GO:0008455; GO:0009312; GO:0016021; GO:0018279; GO:0030246 PATHWAY: Protein modification; protein glycosylation. 0 0 PF05060; Q2T9J0 CHOYP_BRAFLDRAFT_85874.1.1 m.10475 sp TYSD1_HUMAN 31.655 417 249 12 19 416 156 555 6.70E-56 196 TYSD1_HUMAN reviewed "Peroxisomal leader peptide-processing protease (EC 3.4.21.-) (Trypsin domain-containing protein 1) [Cleaved into: Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal leader peptide-processing protease, 45 kDa form]" TYSND1 Homo sapiens (Human) 566 protein homooligomerization [GO:0051260]; protein processing [GO:0016485]; proteolysis [GO:0006508]; regulation of fatty acid beta-oxidation [GO:0031998] GO:0002020; GO:0004252; GO:0005777; GO:0006508; GO:0016020; GO:0016485; GO:0031998; GO:0042802; GO:0051260 0 0 0 0 Q3T8J9 CHOYP_LOC578026.1.1 m.24033 sp GON4L_HUMAN 35.015 337 177 12 31 343 273 591 6.70E-29 122 GON4L_HUMAN reviewed GON-4-like protein (GON-4 homolog) GON4L GON4 KIAA1606 Homo sapiens (Human) 2241 "B cell differentiation [GO:0030183]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003714; GO:0005634; GO:0006351; GO:0030183; GO:0045892 0 0 0 PF02671; Q5ZJU4 CHOYP_LOC100378526.1.1 m.16747 sp URM1_CHICK 71.287 101 27 1 2 100 1 101 6.70E-47 148 URM1_CHICK reviewed Ubiquitin-related modifier 1 URM1 RCJMB04_15k18 Gallus gallus (Chicken) 101 protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] GO:0002098; GO:0005829; GO:0016783; GO:0032447; GO:0034227; GO:0070062 PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03048}. 0 cd01764; PF09138; Q6IN84 CHOYP_LOC101157652.1.1 m.18370 sp MRM1_HUMAN 35.088 228 127 7 78 294 50 267 6.70E-32 124 MRM1_HUMAN reviewed "rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase)" MRM1 Homo sapiens (Human) 353 enzyme-directed rRNA 2'-O-methylation [GO:0000453] GO:0000453; GO:0003723; GO:0005739; GO:0044822; GO:0070039 0 0 0 PF00588;PF08032; Q8MJ14 CHOYP_GPX1.1.4 m.11300 sp GPX1_PIG 62.857 140 51 1 2 140 62 201 6.70E-61 189 GPX1_PIG reviewed Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) GPX1 Sus scrofa (Pig) 206 response to oxidative stress [GO:0006979] GO:0004602; GO:0005737; GO:0006979 0 0 cd00340; PF00255; Q9JIQ3 CHOYP_LOC101157795.1.1 m.48838 sp DBLOH_MOUSE 26.984 252 147 9 12 243 3 237 6.70E-10 61.6 DBLOH_MOUSE reviewed "Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)" Diablo Smac Mus musculus (Mouse) 237 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065] GO:0005737; GO:0005739; GO:0005758; GO:0006919; GO:0008631; GO:0008635; GO:0009898; GO:0035631; GO:0043065; GO:0051402; GO:0097193 0 0 0 PF09057; Q9U943 CHOYP_PHUM_PHUM009400.1.1 m.35298 sp APLP_LOCMI 28.853 1168 731 32 5 1104 9 1144 6.70E-120 433 APLP_LOCMI reviewed Apolipophorins [Cleaved into: Apolipophorin-2 (Apolipophorin II) (apoLp-2); Apolipophorin-1 (Apolipophorin I) (apoLp-1)] 0 Locusta migratoria (Migratory locust) 3380 Wnt signaling pathway [GO:0016055] GO:0005319; GO:0005576; GO:0008289; GO:0016055 0 0 0 PF08742;PF06448;PF09172;PF01347;PF00094; Q9Y6R7 CHOYP_CYCMA_4408.2.3 m.21040 sp FCGBP_HUMAN 26.374 182 128 4 174 354 107 283 6.70E-08 59.3 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; O43301 CHOYP_ISCW_ISCW012626.3.4 m.63674 sp HS12A_HUMAN 31.04 654 375 14 1 598 41 674 6.71E-95 308 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q0IQU1 CHOYP_LOC100206475.7.16 m.37280 sp LAC22_ORYSJ 26.91 602 312 19 100 670 48 552 6.71E-44 169 LAC22_ORYSJ reviewed Laccase-22 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 22) (Diphenol oxidase 22) (Urishiol oxidase 22) LAC22 Os11g0708100 LOC_Os11g48060 OsJ_033548 Oryza sativa subsp. japonica (Rice) 564 lignin biosynthetic process [GO:0009809]; lignin catabolic process [GO:0046274] GO:0005507; GO:0009809; GO:0016722; GO:0046274; GO:0048046; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q14162 CHOYP_MEG10.62.91 m.50415 sp SREC_HUMAN 37.671 146 88 3 2 147 242 384 6.71E-24 102 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q32KN8 CHOYP_LOC585338.2.2 m.40816 sp TBA3_BOVIN 93.561 264 17 0 183 446 47 310 6.71E-172 492 TBA3_BOVIN reviewed Tubulin alpha-3 chain (Alpha-tubulin 3) [Cleaved into: Detyrosinated tubulin alpha-3 chain] TUBA3 Bos taurus (Bovine) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q5F3D1 CHOYP_ZCCHC8.1.1 m.18098 sp ZCHC8_CHICK 29.495 634 341 24 150 701 3 612 6.71E-59 213 ZCHC8_CHICK reviewed Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) ZCCHC8 RCJMB04_21c10 Gallus gallus (Chicken) 613 0 GO:0003676; GO:0005654; GO:0008270 0 0 0 PF04046;PF00098; Q6AZB8 CHOYP_LOC588039.3.6 m.41650 sp HARB1_DANRE 38.393 112 67 2 1 111 72 182 6.71E-14 69.3 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q7RX33 CHOYP_LOC100373045.1.1 m.16824 sp EGT1_NEUCR 21.346 520 299 16 56 508 400 876 6.71E-14 79.3 EGT1_NEUCR reviewed Ergothioneine biosynthesis protein 1 [Includes: L-histidine N(alpha)-methyltransferase (EC 2.1.1.44); Hercynylcysteine S-oxide synthase (EC 1.14.99.51)] egt-1 NCU04343 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 876 ergothioneine biosynthetic process [GO:0052699] GO:0005634; GO:0005737; GO:0030745; GO:0046872; GO:0052699 PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis. {ECO:0000269|PubMed:22209968}. 0 0 PF03781;PF10017; Q7ZSX3 CHOYP_PTF.1.1 m.36704 sp PTF1A_DANRE 53.892 167 67 5 28 191 86 245 6.71E-45 153 PTF1A_DANRE reviewed Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) ptf1a si:zc142h2.2 zgc:112216 Danio rerio (Zebrafish) (Brachydanio rerio) 265 "cell differentiation [GO:0030154]; embryo development [GO:0009790]; exocrine pancreas development [GO:0031017]; generation of neurons [GO:0048699]; hindbrain development [GO:0030902]; organ morphogenesis [GO:0009887]; pancreas development [GO:0031016]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; retinoic acid receptor signaling pathway [GO:0048384]; tissue development [GO:0009888]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0006351; GO:0006355; GO:0009790; GO:0009887; GO:0009888; GO:0030154; GO:0030902; GO:0031016; GO:0031017; GO:0043565; GO:0045893; GO:0048384; GO:0048699 0 0 0 PF00010; Q8BGY4 CHOYP_LOC101071980.1.1 m.56594 sp KLH26_MOUSE 27.592 569 398 10 44 601 16 581 6.71E-67 232 KLH26_MOUSE reviewed Kelch-like protein 26 Klhl26 Mus musculus (Mouse) 606 protein ubiquitination [GO:0016567] GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q8BSN3 CHOYP_BRAFLDRAFT_120788.1.1 m.48466 sp CC151_MOUSE 33.333 102 68 0 19 120 65 166 6.71E-06 47.4 CC151_MOUSE reviewed Coiled-coil domain-containing protein 151 Ccdc151 Mus musculus (Mouse) 593 cilium movement [GO:0003341]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; outer dynein arm assembly [GO:0036158]; regulation of cilium assembly [GO:1902017] GO:0003341; GO:0005814; GO:0005929; GO:0005930; GO:0007368; GO:0007507; GO:0036064; GO:0036158; GO:0061371; GO:1902017 0 0 0 0 Q8VCL5 CHOYP_LOC100371999.1.1 m.51869 sp S17A9_MOUSE 40.455 440 246 4 18 454 12 438 6.71E-118 355 S17A9_MOUSE reviewed Solute carrier family 17 member 9 Slc17a9 Mus musculus (Mouse) 447 anion transport [GO:0006820]; exocytosis [GO:0006887]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitophagy [GO:1903146]; transmembrane transport [GO:0055085] GO:0006820; GO:0006887; GO:0016021; GO:0022857; GO:0055085; GO:1903146; GO:1903955 0 0 cd06174; PF07690; B3EWY9 CHOYP_LOC575161.1.5 m.2449 sp MLP_ACRMI 27.83 1060 620 41 813 1815 394 1365 6.72E-98 355 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O15347 CHOYP_contig_012255 m.14080 sp HMGB3_HUMAN 41.772 79 38 2 89 164 90 163 6.72E-08 55.8 HMGB3_HUMAN reviewed High mobility group protein B3 (High mobility group protein 2a) (HMG-2a) (High mobility group protein 4) (HMG-4) HMGB3 HMG2A HMG4 Homo sapiens (Human) 200 "DNA geometric change [GO:0032392]; DNA recombination [GO:0006310]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; negative regulation of cell differentiation [GO:0045596]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000400; GO:0003690; GO:0005634; GO:0005694; GO:0005737; GO:0006310; GO:0006351; GO:0006355; GO:0007275; GO:0008301; GO:0032392; GO:0044822; GO:0045087; GO:0045596 0 0 0 PF00505;PF09011; O70277 CHOYP_BRAFLDRAFT_87292.6.6 m.59646 sp TRIM3_RAT 25.658 152 109 3 5 153 593 743 6.72E-08 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P46531 CHOYP_AGAP_AGAP002739.5.5 m.60925 sp NOTC1_HUMAN 33.657 618 333 21 485 1088 306 860 6.72E-69 263 NOTC1_HUMAN reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 Homo sapiens (Human) 2555 "aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium morphogenesis [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; organ regeneration [GO:0031100]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral transcription [GO:0050434]; prostate gland epithelium morphogenesis [GO:0060740]; pulmonary valve morphogenesis [GO:0003184]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; tissue regeneration [GO:0042246]; transcription initiation from RNA polymerase II promoter [GO:0006367]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0000139; GO:0001047; GO:0001190; GO:0001669; GO:0001701; GO:0001708; GO:0001837; GO:0001889; GO:0001947; GO:0002040; GO:0002052; GO:0002193; GO:0002437; GO:0003157; GO:0003160; GO:0003162; GO:0003169; GO:0003180; GO:0003181; GO:0003184; GO:0003192; GO:0003198; GO:0003203; GO:0003207; GO:0003208; GO:0003209; GO:0003213; GO:0003214; GO:0003219; GO:0003222; GO:0003241; GO:0003256; GO:0003270; GO:0003273; GO:0003344; GO:0003700; GO:0004857; GO:0004872; GO:0005509; GO:0005576; GO:0005634; GO:0005654; GO:0005789; GO:0005829; GO:0005886; GO:0005912; GO:0006355; GO:0006367; GO:0006955; GO:0006959; GO:0007219; GO:0007221; GO:0007283; GO:0007368; GO:0007386; GO:0007409; GO:0007440; GO:0007492; GO:0007507; GO:0008284; GO:0008285; GO:0009912; GO:0009986; GO:0010718; GO:0010812; GO:0010832; GO:0014031; GO:0014807; GO:0016021; GO:0016324; GO:0019899; GO:0021515; GO:0021915; GO:0030216; GO:0030279; GO:0030324; GO:0030335; GO:0030513; GO:0030514; GO:0030900; GO:0031069; GO:0031100; GO:0031490; GO:0031960; GO:0032495; GO:0032496; GO:0035116; GO:0035148; GO:0035914; GO:0035924; GO:0042246; GO:0043065; GO:0043086; GO:0043235; GO:0043565; GO:0045070; GO:0045603; GO:0045608; GO:0045618; GO:0045662; GO:0045668; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0045955; GO:0046427; GO:0046533; GO:0048103; GO:0048708; GO:0048709; GO:0048711; GO:0048715; GO:0048754; GO:0050434; GO:0050679; GO:0050768; GO:0055008; GO:0060038; GO:0060045; GO:0060253; GO:0060271; GO:0060317; GO:0060411; GO:0060412; GO:0060528; GO:0060740; GO:0060768; GO:0060842; GO:0060843; GO:0060948; GO:0060956; GO:0060979; GO:0060982; GO:0061314; GO:0061384; GO:0061419; GO:0070986; GO:0071372; GO:0072017; GO:0072044; GO:0072144; GO:0072602; GO:0090051; GO:0090090; GO:0097150; GO:1901201; GO:1902263; GO:2000737; GO:2000811; GO:2000974; GO:2001027 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P51449 CHOYP_LOC100162388.1.1 m.65827 sp RORG_HUMAN 24.242 462 310 15 39 491 31 461 6.72E-23 105 RORG_HUMAN reviewed Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma) RORC NR1F3 RORG RZRG Homo sapiens (Human) 518 "adipose tissue development [GO:0060612]; cellular response to sterol [GO:0036315]; circadian regulation of gene expression [GO:0032922]; lymph node development [GO:0048535]; negative regulation of thymocyte apoptotic process [GO:0070244]; Peyer's patch development [GO:0048541]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; regulation of glucose metabolic process [GO:0010906]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription involved in cell fate commitment [GO:0060850]; T-helper 17 cell differentiation [GO:0072539]; T-helper cell differentiation [GO:0042093]; transcription initiation from RNA polymerase II promoter [GO:0006367]; xenobiotic metabolic process [GO:0006805]" GO:0003677; GO:0003700; GO:0003707; GO:0004879; GO:0005634; GO:0005654; GO:0005730; GO:0006367; GO:0006805; GO:0008142; GO:0008270; GO:0010906; GO:0019218; GO:0032922; GO:0036315; GO:0042093; GO:0042753; GO:0043231; GO:0043565; GO:0045598; GO:0045893; GO:0048535; GO:0048541; GO:0060612; GO:0060850; GO:0070244; GO:0072539; GO:0098531 0 0 0 PF00104;PF00105; P82924 CHOYP_AAEL_AAEL011814.1.1 m.48797 sp RT30_BOVIN 46.154 104 55 1 417 519 324 427 6.72E-21 99 RT30_BOVIN reviewed "28S ribosomal protein S30, mitochondrial (MRP-S30) (S30mt)" MRPS30 Bos taurus (Bovine) 435 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005840; GO:0044822; GO:0070124; GO:0070125 0 0 0 PF07147; Q09575 CHOYP_LOC754701.6.7 m.35191 sp YRD6_CAEEL 31.325 166 106 3 19 183 837 995 6.72E-20 89.7 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q3SWY8 CHOYP_AAEL_AAEL013635.1.1 m.54371 sp ZUFSP_BOVIN 43.194 382 187 8 427 785 194 568 6.72E-94 308 ZUFSP_BOVIN reviewed Zinc finger with UFM1-specific peptidase domain protein ZUFSP Bos taurus (Bovine) 579 0 GO:0046872 0 0 0 PF07910; Q495T6 CHOYP_MMEL1.1.3 m.2535 sp MMEL1_HUMAN 39.508 691 397 9 89 764 87 771 6.72E-171 514 MMEL1_HUMAN reviewed "Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))]" MMEL1 MELL1 MMEL2 NEP2 Homo sapiens (Human) 779 0 GO:0004222; GO:0005576; GO:0016021; GO:0046872 0 0 cd08662; PF01431;PF05649; Q5NC57 CHOYP_LOC100185469.2.2 m.49997 sp F183B_MOUSE 53.846 117 54 0 16 132 14 130 6.72E-34 118 F183B_MOUSE reviewed Protein FAM183B Fam183b Mus musculus (Mouse) 135 0 0 0 0 0 PF14886; Q5NC57 CHOYP_LOC100379066.1.1 m.64533 sp F183B_MOUSE 53.846 117 54 0 16 132 14 130 6.72E-34 118 F183B_MOUSE reviewed Protein FAM183B Fam183b Mus musculus (Mouse) 135 0 0 0 0 0 PF14886; Q5T619 CHOYP_ISCW_ISCW016591.1.1 m.6944 sp ZN648_HUMAN 29.003 331 185 7 631 928 241 554 6.72E-38 154 ZN648_HUMAN reviewed Zinc finger protein 648 ZNF648 Homo sapiens (Human) 568 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q5XI68 CHOYP_BRAFLDRAFT_68934.1.2 m.57609 sp NC2B_RAT 71.127 142 41 0 4 145 1 142 6.72E-68 207 NC2B_RAT reviewed Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein) Dr1 Rattus norvegicus (Rat) 176 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF00808; Q5Y5T3 CHOYP_LOC100549654.1.1 m.11692 sp ZDH23_MOUSE 32.151 423 267 8 2 415 8 419 6.72E-68 224 ZDH23_MOUSE reviewed Palmitoyltransferase ZDHHC23 (EC 2.3.1.225) (DHHC-containing protein 11) (Zinc finger DHHC domain-containing protein 23) (DHHC-23) (zDHHC23) Zdhhc23 Gm779 Mus musculus (Mouse) 425 protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345] GO:0008270; GO:0016021; GO:0018345; GO:0019706; GO:0072659 0 0 0 PF01529; Q63073 CHOYP_LOC577905.2.2 m.15927 sp BTG1_RAT 47.205 161 80 2 1 156 11 171 6.72E-48 156 BTG1_RAT reviewed Protein BTG1 (Anti-proliferative factor) (B-cell translocation gene 1 protein) Btg1 Rattus norvegicus (Rat) 171 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein methylation [GO:0006479]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0006479; GO:0006979; GO:0007283; GO:0007286; GO:0008285; GO:0019899; GO:0043434; GO:0045603; GO:0045766; GO:2000271 0 0 0 PF07742; Q63073 CHOYP_LOC591901.1.3 m.9106 sp BTG1_RAT 47.205 161 80 2 1 156 11 171 6.72E-48 156 BTG1_RAT reviewed Protein BTG1 (Anti-proliferative factor) (B-cell translocation gene 1 protein) Btg1 Rattus norvegicus (Rat) 171 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein methylation [GO:0006479]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283] GO:0005634; GO:0005737; GO:0006479; GO:0006979; GO:0007283; GO:0007286; GO:0008285; GO:0019899; GO:0043434; GO:0045603; GO:0045766; GO:2000271 0 0 0 PF07742; Q64425 CHOYP_LIPP.1.1 m.30893 sp LIPP_MYOCO 40.043 467 258 10 40 504 9 455 6.72E-114 347 LIPP_MYOCO reviewed Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) (Fragment) PNLIP Myocastor coypus (Coypu) (Nutria) 457 lipid catabolic process [GO:0016042] GO:0004806; GO:0005576; GO:0016042; GO:0046872 0 0 0 PF00151;PF01477; Q6DCG4 CHOYP_LOC100370684.1.2 m.61027 sp RHBGB_XENLA 49.002 451 194 8 6 439 7 438 6.72E-145 425 RHBGB_XENLA reviewed Ammonium transporter Rh type B-B (Rhesus blood group family type B glycoprotein B) (Rh family type B glycoprotein B) (Rh type B glycoprotein B) rhbg-b Xenopus laevis (African clawed frog) 460 0 GO:0008519; GO:0016021; GO:0016323; GO:0030659 0 0 0 PF00909; Q8JIU7 CHOYP_NACA.7.9 m.62592 sp NACA_DANRE 62.5 96 28 3 9 96 1 96 6.72E-21 85.9 NACA_DANRE reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Danio rerio (Zebrafish) (Brachydanio rerio) 215 myofibril assembly [GO:0030239]; protein transport [GO:0015031] GO:0005634; GO:0005737; GO:0015031; GO:0030239 0 0 0 PF01849; Q8VHI5 CHOYP_LOC100708991.4.5 m.43849 sp VITRN_MOUSE 24.727 275 180 9 1068 1338 349 600 6.72E-07 58.2 VITRN_MOUSE reviewed Vitrin Vit Mus musculus (Mouse) 650 extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0005539; GO:0005578; GO:0005614; GO:0010811; GO:0030198 0 0 0 PF03815;PF00092; P47967 CHOYP_LOC100378653.2.3 m.43279 sp LEG5_RAT 44.203 138 68 3 27 163 15 144 6.73E-29 106 LEG5_RAT reviewed Galectin-5 (Gal-5) (RL-18) Lgals5 Rattus norvegicus (Rat) 145 0 GO:0030246 0 0 0 PF00337; P57078 CHOYP_LOC100890587.2.2 m.54479 sp RIPK4_HUMAN 35.106 188 119 2 3 188 528 714 6.73E-32 124 RIPK4_HUMAN reviewed Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase) RIPK4 ANKRD3 DIK Homo sapiens (Human) 832 morphogenesis of an epithelium [GO:0002009]; positive regulation of NF-kappaB transcription factor activity [GO:0051092] GO:0002009; GO:0004674; GO:0005524; GO:0005737; GO:0016020; GO:0051092 0 0 0 PF12796;PF00069; Q2EMV9 CHOYP_BRAFLDRAFT_74879.1.6 m.21111 sp PAR14_MOUSE 25.202 619 385 20 1188 1783 1252 1815 6.73E-48 192 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5U4U6 CHOYP_T23O.5.6 m.52216 sp T23O_XENLA 39.13 345 193 5 8 336 40 383 6.73E-82 257 T23O_XENLA reviewed "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" tdo2 Xenopus laevis (African clawed frog) 406 tryptophan catabolic process to kynurenine [GO:0019441] GO:0004833; GO:0019441; GO:0020037; GO:0046872 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}. 0 0 PF03301; Q62158 CHOYP_LOC100367600.2.2 m.39016 sp TRI27_MOUSE 25.604 207 140 4 43 237 69 273 6.73E-07 53.9 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q8K259 CHOYP_LOC578054.3.7 m.17052 sp GIN1_MOUSE 28.221 163 114 2 472 634 63 222 6.73E-17 87.8 GIN1_MOUSE reviewed Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Zinc finger H2C2 domain-containing protein) Gin1 Zh2c2 Mus musculus (Mouse) 518 DNA integration [GO:0015074] GO:0003676; GO:0015074 0 0 0 0 Q96S38 CHOYP_LOC100371127.1.1 m.23427 sp KS6C1_HUMAN 49.73 185 93 0 981 1165 880 1064 6.73E-59 224 KS6C1_HUMAN reviewed Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein) RPS6KC1 RPK118 Homo sapiens (Human) 1066 signal transduction [GO:0007165] GO:0004674; GO:0005524; GO:0005737; GO:0005769; GO:0007165; GO:0016020; GO:0035091; GO:0043231 0 0 0 PF04212;PF00069;PF00787; Q98TR7 CHOYP_RS16.1.5 m.29366 sp RS16_HETFO 71.951 82 23 0 1 82 26 107 6.73E-40 132 RS16_HETFO reviewed 40S ribosomal protein S16 rps16 Heteropneustes fossilis (Stinging catfish) 146 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00380; Q9C040 CHOYP_BRAFLDRAFT_86890.3.4 m.34852 sp TRIM2_HUMAN 25.571 219 142 6 187 395 535 742 6.73E-10 64.7 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9CZJ2 CHOYP_LOC100372773.9.9 m.66399 sp HS12B_MOUSE 28.838 482 274 9 8 433 61 529 6.73E-55 196 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9ESN6 CHOYP_contig_028554 m.32489 sp TRIM2_MOUSE 27.957 186 117 8 223 400 524 700 6.73E-07 55.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JJL8 CHOYP_AGAP_AGAP000991.1.1 m.5123 sp SYSM_MOUSE 46.847 333 171 4 92 420 155 485 6.73E-105 323 SYSM_MOUSE reviewed "Serine--tRNA ligase, mitochondrial (EC 6.1.1.11) (SerRSmt) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)" Sars2 Sarsm Mus musculus (Mouse) 518 selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; seryl-tRNA aminoacylation [GO:0006434] GO:0004828; GO:0005524; GO:0005737; GO:0005739; GO:0005759; GO:0006434; GO:0044822; GO:0097056 PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. 0 cd00770; PF02403;PF00587; O75382 CHOYP_LOC100373444.67.79 m.60334 sp TRIM3_HUMAN 21.499 507 335 17 57 532 110 584 6.74E-11 68.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O94854 CHOYP_BRAFLDRAFT_59661.1.6 m.19943 sp K0754_HUMAN 39.796 98 58 1 99 196 902 998 6.74E-06 50.1 K0754_HUMAN reviewed Uncharacterized protein KIAA0754 KIAA0754 Homo sapiens (Human) 1291 0 GO:0005886 0 0 0 0 P13908 CHOYP_LOC100372793.1.1 m.6734 sp ACHN2_CARAU 26.934 349 242 6 8 348 100 443 6.74E-34 133 ACHN2_CARAU reviewed Neuronal acetylcholine receptor subunit non-alpha-2 (GFN-alpha-2) 0 Carassius auratus (Goldfish) 462 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; P95896 CHOYP_contig_034847 m.39553 sp AMID_SULSO 49.5 400 194 4 1 396 106 501 6.74E-125 373 AMID_SULSO reviewed Amidase (EC 3.5.1.4) SSO2122 C02016 C02_017 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 504 0 GO:0004040; GO:0016884 0 0 0 PF01425; Q11212 CHOYP_LOC581500.1.1 m.9175 sp ACT_SPOLI 98.077 104 2 0 1 104 35 138 6.74E-74 219 ACT_SPOLI reviewed Actin (Fragment) 0 Spodoptera littoralis (Egyptian cotton leafworm) 164 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q502M6 CHOYP_LOC755521.1.28 m.21060 sp ANR29_DANRE 36.792 212 126 2 1 205 67 277 6.74E-34 125 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5RC74 CHOYP_LOC581513.1.1 m.10513 sp DERL2_PONAB 66.949 236 75 1 3 238 4 236 6.74E-119 342 DERL2_PONAB reviewed Derlin-2 (Degradation in endoplasmic reticulum protein 2) (Der1-like protein 2) DERL2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 239 "endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; positive regulation of cell growth [GO:0030307]; positive regulation of cell proliferation [GO:0008284]; retrograde protein transport, ER to cytosol [GO:0030970]; suckling behavior [GO:0001967]" GO:0001967; GO:0005769; GO:0005770; GO:0008284; GO:0030176; GO:0030307; GO:0030433; GO:0030968; GO:0030970; GO:1904153 0 0 0 0 Q91147 CHOYP_NORK.2.2 m.56378 sp FGFR2_NOTVI 43.81 315 153 4 544 847 381 682 6.74E-79 275 FGFR2_NOTVI reviewed Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) FGFR2 Notophthalmus viridescens (Eastern newt) (Triturus viridescens) 729 apoptotic process [GO:0006915]; positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0005794; GO:0005886; GO:0006915; GO:0008284; GO:0016021; GO:0016023 0 0 0 PF07679;PF07714; Q9BQI6 CHOYP_LOC100373214.1.1 m.18828 sp SLF1_HUMAN 46.296 162 67 3 737 896 788 931 6.74E-31 135 SLF1_HUMAN reviewed SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) SLF1 ANKRD32 BRCTD1 Homo sapiens (Human) 1058 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; positive regulation of double-strand break repair [GO:2000781]; positive regulation of maintenance of mitotic sister chromatid cohesion [GO:0034184]; positive regulation of protein complex assembly [GO:0031334]; protein localization to site of double-strand break [GO:1990166] GO:0000786; GO:0005634; GO:0005737; GO:0005813; GO:0006281; GO:0006974; GO:0031334; GO:0031625; GO:0032403; GO:0034184; GO:0035861; GO:0042405; GO:1990166; GO:2000781 0 0 0 PF12796;PF16770; Q9JHE7 CHOYP_PHUM_PHUM519460.1.1 m.3701 sp TSSC4_MOUSE 34.677 124 75 4 125 247 106 224 6.74E-12 68.6 TSSC4_MOUSE reviewed Protein TSSC4 Tssc4 MNCb-3063 Mus musculus (Mouse) 317 0 0 0 0 0 PF15264; A3DBD7 CHOYP_LOC574855.3.9 m.8909 sp BIOC_CLOTH 30.952 126 82 2 149 274 17 137 6.75E-09 59.7 BIOC_CLOTH reviewed Malonyl-[acyl-carrier protein] O-methyltransferase (Malonyl-ACP O-methyltransferase) (EC 2.1.1.197) (Biotin synthesis protein BioC) bioC Cthe_0024 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 283 biotin biosynthetic process [GO:0009102] GO:0009102; GO:0010340 PATHWAY: Cofactor biosynthesis; biotin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00835}. 0 0 PF13847; B6NXD5 CHOYP_BRE.1.1 m.11410 sp BRE_BRAFL 50.532 376 176 6 2 369 10 383 6.75E-127 372 BRE_BRAFL reviewed BRCA1-A complex subunit BRE (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) BRE BRAFLDRAFT_269508 Branchiostoma floridae (Florida lancelet) (Amphioxus) 383 apoptotic process [GO:0006915]; cell division [GO:0051301]; covalent chromatin modification [GO:0016569]; double-strand break repair [GO:0006302]; G2 DNA damage checkpoint [GO:0031572]; mitotic nuclear division [GO:0007067]; positive regulation of DNA repair [GO:0045739]; response to ionizing radiation [GO:0010212] GO:0005634; GO:0005737; GO:0006302; GO:0006915; GO:0007067; GO:0010212; GO:0016569; GO:0031572; GO:0031593; GO:0045739; GO:0051301; GO:0070531; GO:0070552 0 0 0 PF06113; O88281 CHOYP_MEGF6.56.59 m.61113 sp MEGF6_RAT 37.666 377 198 20 193 568 909 1249 6.75E-47 180 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P20351 CHOYP_BRAFLDRAFT_210874.1.1 m.28596 sp T23O_DROME 57.6 375 146 5 2 369 6 374 6.75E-152 437 T23O_DROME reviewed "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Protein vermilion) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" v CG5163 Drosophila melanogaster (Fruit fly) 379 compound eye pigmentation [GO:0048072]; kynurenine metabolic process [GO:0070189]; ommochrome biosynthetic process [GO:0006727]; positive regulation of neuron death [GO:1901216]; tryptophan catabolic process [GO:0006569]; tryptophan catabolic process to acetyl-CoA [GO:0019442]; tryptophan catabolic process to kynurenine [GO:0019441] GO:0004833; GO:0006569; GO:0006727; GO:0019441; GO:0019442; GO:0020037; GO:0046872; GO:0048072; GO:0070189; GO:1901216 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}.; PATHWAY: Pigment biosynthesis; ommochrome biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03020}. 0 0 PF03301; P62282 CHOYP_contig_023234 m.26433 sp RS11_RAT 78.462 130 25 1 3 132 22 148 6.75E-72 215 RS11_RAT reviewed 40S ribosomal protein S11 Rps11 Rattus norvegicus (Rat) 158 osteoblast differentiation [GO:0001649]; translation [GO:0006412] GO:0001649; GO:0003735; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0019843; GO:0022627; GO:0044822; GO:0070062 0 0 0 PF00366;PF16205; Q5BIM1 CHOYP_NEMVEDRAFT_V1G198897.5.6 m.60206 sp TRI45_BOVIN 22.198 464 303 15 27 452 29 472 6.75E-16 83.6 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5EAR5 CHOYP_BRAFLDRAFT_265162.3.3 m.64003 sp TRPT1_DANRE 50.732 205 94 4 198 398 23 224 6.75E-63 213 TRPT1_DANRE reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) trpt1 zgc:113138 Danio rerio (Zebrafish) (Brachydanio rerio) 225 "tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388 0 0 0 PF01885; Q80YG3 CHOYP_KLDC1.1.2 m.958 sp KLDC1_MOUSE 38.793 232 118 9 64 283 4 223 6.75E-36 135 KLDC1_MOUSE reviewed Kelch domain-containing protein 1 Klhdc1 Mus musculus (Mouse) 406 0 GO:0005737 0 0 0 PF07646; Q86Y13 CHOYP_LOC100372716.4.10 m.23004 sp DZIP3_HUMAN 30.233 86 60 0 64 149 455 540 6.75E-08 54.7 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8WZ42 CHOYP_LOC100375089.1.1 m.1343 sp TITIN_HUMAN 30 120 79 4 4 118 14833 14952 6.75E-06 47.8 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q94051 CHOYP_CAV1.2.4 m.10380 sp CAV1_CAEEL 54.545 44 19 1 6 49 100 142 6.75E-10 58.2 CAV1_CAEEL reviewed Caveolin-1 cav-1 T13F2.8 Caenorhabditis elegans 235 caveola assembly [GO:0070836]; meiotic nuclear division [GO:0007126]; Ras protein signal transduction [GO:0007265]; regulation of oviposition [GO:0046662] GO:0000139; GO:0005887; GO:0005901; GO:0005938; GO:0007126; GO:0007265; GO:0009898; GO:0030133; GO:0032947; GO:0045121; GO:0046662; GO:0048471; GO:0060473; GO:0070836 0 0 0 PF01146; Q9CRB6 CHOYP_PEAR1.9.16 m.42308 sp TPPP3_MOUSE 41.176 187 85 9 1 176 1 173 6.75E-23 92.8 TPPP3_MOUSE reviewed Tubulin polymerization-promoting protein family member 3 Tppp3 Mus musculus (Mouse) 176 microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785] GO:0001578; GO:0005737; GO:0005874; GO:0015631; GO:0046785; GO:0070062 0 0 0 PF05517; Q9CRB6 CHOYP_RS23.6.9 m.37683 sp TPPP3_MOUSE 41.176 187 85 9 1 176 1 173 6.75E-23 92.8 TPPP3_MOUSE reviewed Tubulin polymerization-promoting protein family member 3 Tppp3 Mus musculus (Mouse) 176 microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785] GO:0001578; GO:0005737; GO:0005874; GO:0015631; GO:0046785; GO:0070062 0 0 0 PF05517; Q9ERS5 CHOYP_PLEKHA2.1.1 m.44629 sp PKHA2_MOUSE 40.625 320 157 8 66 356 1 316 6.75E-67 223 PKHA2_MOUSE reviewed Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (PH domain-containing adaptor PHAD47) (Tandem PH domain-containing protein 2) (TAPP-2) Plekha2 Tapp2 Mus musculus (Mouse) 425 positive regulation of cell-matrix adhesion [GO:0001954] GO:0001954; GO:0001968; GO:0005545; GO:0005634; GO:0005737; GO:0005886; GO:0016020; GO:0030165; GO:0043234; GO:0043236 0 0 0 PF00169; Q9ESN6 CHOYP_TRIADDRAFT_23736.1.1 m.32257 sp TRIM2_MOUSE 27.5 200 129 7 197 391 535 723 6.75E-09 61.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9P959 CHOYP_LOC100637288.1.1 m.25195 sp AOX_EMENI 52.72 239 101 3 102 328 86 324 6.75E-85 263 AOX_EMENI reviewed "Alternative oxidase, mitochondrial (EC 1.-.-.-)" alxA aod-1 AN2099 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 354 0 GO:0005739; GO:0005743; GO:0009916; GO:0016021; GO:0046872; GO:0070469 0 0 0 PF01786; Q9S9V0 CHOYP_NEMVEDRAFT_V1G129909.9.9 m.66768 sp CDPKV_ARATH 31.25 128 87 1 37 163 337 464 6.75E-12 66.2 CDPKV_ARATH reviewed Calcium-dependent protein kinase 31 (EC 2.7.11.1) CPK31 At4g04695 T19J18.7 Arabidopsis thaliana (Mouse-ear cress) 484 abscisic acid-activated signaling pathway [GO:0009738]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; response to salicylic acid [GO:0009751] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0009738; GO:0009751; GO:0009931; GO:0016020; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; Q9U639 CHOYP_BRAFLDRAFT_114843.2.2 m.57233 sp HSP7D_MANSE 88.034 234 24 1 8 241 6 235 6.75E-148 430 HSP7D_MANSE reviewed Heat shock 70 kDa protein cognate 4 (Hsc 70-4) 0 Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 652 0 GO:0005524; GO:0005634 0 0 0 PF00012; B2GV71 CHOYP_LOC754687.1.1 m.30472 sp NDUF5_RAT 51.701 294 140 2 41 333 44 336 6.76E-110 327 NDUF5_RAT reviewed "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (Probable methyltransferase C20orf7 homolog, mitochondrial) (EC 2.1.1.-)" Ndufaf5 Rattus norvegicus (Rat) 343 mitochondrial respiratory chain complex I assembly [GO:0032981] GO:0008168; GO:0031314; GO:0032981 0 0 0 PF08241; O88384 CHOYP_BRAFLDRAFT_117821.1.1 m.16201 sp VTI1B_MOUSE 48.661 224 106 3 2 217 7 229 6.76E-63 198 VTI1B_MOUSE reviewed Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1) Vti1b Vti1l1 Mus musculus (Mouse) 232 "ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein targeting to vacuole [GO:0006623]; regulation of protein localization to plasma membrane [GO:1903076]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion with Golgi apparatus [GO:0048280]" GO:0000149; GO:0005484; GO:0005737; GO:0005765; GO:0005789; GO:0005794; GO:0005829; GO:0006623; GO:0006888; GO:0006891; GO:0006896; GO:0012507; GO:0016021; GO:0019869; GO:0031201; GO:0031902; GO:0031982; GO:0042147; GO:0043231; GO:0048280; GO:0048471; GO:0055037; GO:1903076 0 0 0 PF05008; P62909 CHOYP_RS3.5.7 m.46182 sp RS3_RAT 90 130 12 1 21 150 107 235 6.76E-81 241 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; P69098 CHOYP_CALM.38.50 m.53773 sp CALM_TRYBG 48 150 74 2 39 188 1 146 6.76E-39 133 CALM_TRYBG reviewed Calmodulin (CaM) 0 Trypanosoma brucei gambiense 149 0 GO:0005509 0 0 0 PF13499; P80009 CHOYP_LOC100880993.1.1 m.9994 sp PLMN_CANLF 39.583 288 152 8 189 468 60 333 6.76E-59 199 PLMN_CANLF reviewed Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Plasmin light chain B] (Fragment) PLG Canis lupus familiaris (Dog) (Canis familiaris) 333 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00089; Q04861 CHOYP_NFKB.1.1 m.51558 sp NFKB1_CHICK 51.462 342 155 3 19 350 35 375 6.76E-108 364 NFKB1_CHICK reviewed Nuclear factor NF-kappa-B p105 subunit (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] NFKB1 Gallus gallus (Chicken) 983 cellular response to dsRNA [GO:0071359]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to peptide hormone stimulus [GO:0071375]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 biosynthetic process [GO:0045083]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cytokine [GO:0034097]; response to muscle stretch [GO:0035994] GO:0000122; GO:0000977; GO:0000980; GO:0000981; GO:0001205; GO:0001227; GO:0003682; GO:0005654; GO:0005739; GO:0005829; GO:0006954; GO:0007249; GO:0010956; GO:0033256; GO:0034097; GO:0035994; GO:0038061; GO:0045083; GO:0045087; GO:0045944; GO:0050728; GO:0051059; GO:0071222; GO:0071260; GO:0071316; GO:0071347; GO:0071354; GO:0071359; GO:0071375; GO:0090263; GO:1900127; GO:2000630 0 0 0 PF12796;PF00531;PF16179;PF00554; Q05707 CHOYP_ITAX.1.1 m.57929 sp COEA1_HUMAN 29.493 217 133 6 23 227 158 366 6.76E-16 83.2 COEA1_HUMAN reviewed Collagen alpha-1(XIV) chain (Undulin) COL14A1 UND Homo sapiens (Human) 1796 collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0005201; GO:0005518; GO:0005576; GO:0005578; GO:0005581; GO:0005596; GO:0005615; GO:0005788; GO:0016337; GO:0030198; GO:0030199; GO:0030674; GO:0044822; GO:0070062 0 0 0 PF01391;PF00041;PF00092; Q13148 CHOYP_LOC656201.1.1 m.8657 sp TADBP_HUMAN 49.423 433 170 12 1 429 1 388 6.76E-123 367 TADBP_HUMAN reviewed TAR DNA-binding protein 43 (TDP-43) TARDBP TDP43 Homo sapiens (Human) 414 3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear fragmentation involved in apoptotic nuclear change [GO:0030264]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; regulation of cell cycle [GO:0051726]; response to endoplasmic reticulum stress [GO:0034976]; RNA splicing [GO:0008380]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000166; GO:0001205; GO:0001933; GO:0003690; GO:0003700; GO:0003723; GO:0003730; GO:0005634; GO:0005654; GO:0005726; GO:0005737; GO:0006366; GO:0006397; GO:0008380; GO:0010629; GO:0016607; GO:0030264; GO:0032024; GO:0034976; GO:0035061; GO:0042802; GO:0043922; GO:0044822; GO:0051726; GO:0070935; GO:0071765 0 0 0 PF00076; Q15751 CHOYP_LOC100538796.1.1 m.58597 sp HERC1_HUMAN 43.011 186 90 4 1 180 4 179 6.76E-38 143 HERC1_HUMAN reviewed Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619) HERC1 Homo sapiens (Human) 4861 cerebellar Purkinje cell differentiation [GO:0021702]; negative regulation of autophagy [GO:0010507]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; transport [GO:0006810] GO:0004842; GO:0005086; GO:0005737; GO:0005794; GO:0005829; GO:0006810; GO:0010507; GO:0016020; GO:0016874; GO:0021702; GO:0031175; GO:0050885 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632;PF00415;PF00622;PF00400; Q52KG5 CHOYP_KIF26A.1.1 m.41193 sp KI26A_MOUSE 53.618 539 214 14 618 1127 289 820 6.76E-151 518 KI26A_MOUSE reviewed Kinesin-like protein KIF26A Kif26a Kiaa1236 Mus musculus (Mouse) 1881 axon guidance [GO:0007411]; cytoskeleton-dependent intracellular transport [GO:0030705]; enteric nervous system development [GO:0048484]; negative regulation of signal transduction [GO:0009968]; protein localization [GO:0008104]; regulation of cell growth by extracellular stimulus [GO:0001560] GO:0001560; GO:0005524; GO:0005737; GO:0005871; GO:0005874; GO:0007411; GO:0008017; GO:0008104; GO:0009968; GO:0030705; GO:0048484 0 0 0 PF00225; Q5RAP9 CHOYP_LOC100182289.2.2 m.49935 sp AT5G2_PONAB 66.346 104 30 1 4 107 42 140 6.76E-42 137 AT5G2_PONAB reviewed "ATP synthase F(0) complex subunit C2, mitochondrial (ATP synthase lipid-binding protein) (ATP synthase proteolipid P2) (ATPase protein 9) (ATPase subunit c)" ATP5G2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 141 ATP hydrolysis coupled proton transport [GO:0015991]; ATP synthesis coupled proton transport [GO:0015986] GO:0008289; GO:0015078; GO:0015986; GO:0015991; GO:0016021; GO:0031966; GO:0045263 0 0 0 PF00137; Q5RHP9 CHOYP_LOC100179357.3.6 m.22343 sp ERIC3_HUMAN 34.945 455 221 10 1 435 1 400 6.76E-68 256 ERIC3_HUMAN reviewed Glutamate-rich protein 3 ERICH3 C1orf173 Homo sapiens (Human) 1530 0 0 0 0 0 PF15257; Q6ZRF8 CHOYP_LOC100369754.2.10 m.3767 sp RN207_HUMAN 21.762 193 130 8 1 187 117 294 6.76E-06 50.4 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8K0U4 CHOYP_LOC656992.3.3 m.42648 sp HS12A_MOUSE 33.441 311 188 8 4 302 361 664 6.76E-42 156 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8K3K9 CHOYP_LOC100331400.1.2 m.50576 sp GIMA4_RAT 37.647 85 45 2 233 309 30 114 6.76E-08 56.6 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9UGM3 CHOYP_DMBT1.25.34 m.49775 sp DMBT1_HUMAN 53.488 129 53 4 136 262 79 202 6.76E-32 127 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; P55042 CHOYP_BRAFLDRAFT_65681.1.1 m.448 sp RAD_HUMAN 44.615 65 36 0 11 75 197 261 6.77E-12 63.5 RAD_HUMAN reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) RRAD RAD Homo sapiens (Human) 308 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; Q0P5B3 CHOYP_AGAP_AGAP010391.2.2 m.44517 sp RBTN1_BOVIN 77.778 126 28 0 14 139 19 144 6.77E-72 216 RBTN1_BOVIN reviewed Rhombotin-1 (LIM domain only protein 1) (LMO-1) LMO1 RBTN1 Bos taurus (Bovine) 156 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of T cell homeostatic proliferation [GO:0046013] GO:0000122; GO:0005634; GO:0008270; GO:0045944; GO:0046013 0 0 0 PF00412; Q14517 CHOYP_FAT1.2.4 m.36735 sp FAT1_HUMAN 27.256 532 350 19 27 540 2916 3428 6.77E-24 112 FAT1_HUMAN reviewed "Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]" FAT1 CDHF7 FAT Homo sapiens (Human) 4588 actin filament organization [GO:0007015]; anatomical structure morphogenesis [GO:0009653]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell migration [GO:0016477]; establishment or maintenance of cell polarity [GO:0007163]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; single organismal cell-cell adhesion [GO:0016337] GO:0005509; GO:0005634; GO:0005886; GO:0005887; GO:0005911; GO:0005925; GO:0007015; GO:0007155; GO:0007156; GO:0007163; GO:0007267; GO:0009653; GO:0016337; GO:0016477; GO:0030027; GO:0030175; GO:0048471; GO:0070062 0 0 0 PF00028;PF00008;PF02210; Q5UQH0 CHOYP_BRAFLDRAFT_75378.1.1 m.59437 sp YR815_MIMIV 36.986 73 40 2 67 133 186 258 6.77E-06 48.5 YR815_MIMIV reviewed Putative sel1-like repeat-containing protein R815 MIMI_R815 Acanthamoeba polyphaga mimivirus (APMV) 540 0 0 0 0 0 PF08238; D2GXS7 CHOYP_ARGI.1.2 m.3262 sp TRIM2_AILME 23.973 146 107 3 403 545 599 743 6.78E-06 52.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_87310.2.3 m.41553 sp TRIM3_HUMAN 26.974 152 101 7 688 834 597 743 6.78E-06 53.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P49013 CHOYP_NEMVEDRAFT_V1G52068.2.3 m.36345 sp FBP3_STRPU 50.435 115 55 2 110 224 216 328 6.78E-29 124 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P86856 CHOYP_MANL.3.9 m.24477 sp MANL_MYTCA 47.799 159 76 3 75 229 1 156 6.78E-37 140 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q0KK59 CHOYP_LOC100374509.1.1 m.338 sp UNC79_MOUSE 37.853 531 254 11 1 461 1 525 6.78E-116 377 UNC79_MOUSE reviewed Protein unc-79 homolog Unc79 Kiaa1409 Mus musculus (Mouse) 2596 adult behavior [GO:0030534]; behavioral response to ethanol [GO:0048149]; multicellular organism growth [GO:0035264] GO:0016021; GO:0030534; GO:0035264; GO:0048149 0 0 0 0 Q2PC93 CHOYP_BRAFLDRAFT_118602.2.5 m.17419 sp SSPO_CHICK 34.22 1166 669 38 225 1349 192 1300 6.78E-177 621 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q4LDE5 CHOYP_LOC100367084.11.22 m.47953 sp SVEP1_HUMAN 25.637 706 410 27 197 821 435 1106 6.78E-38 160 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5G267 CHOYP_LOC100639603.1.1 m.64844 sp NETR_MACMU 33.929 280 140 13 2 252 316 579 6.78E-37 142 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5UBV8 CHOYP_LOC100374741.24.83 m.21313 sp TNF15_MOUSE 27.607 163 106 5 105 260 95 252 6.78E-07 52.4 TNF15_MOUSE reviewed Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) Tnfsf15 Tl1 Vegi Mus musculus (Mouse) 252 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cytokine metabolic process [GO:0042107]; immune response [GO:0006955] GO:0005615; GO:0005622; GO:0005886; GO:0006919; GO:0006955; GO:0007250; GO:0016021; GO:0042107 0 0 0 PF00229; Q5ZIJ9 CHOYP_LOC100370069.1.14 m.25753 sp MIB2_CHICK 44.118 68 31 1 379 439 11 78 6.78E-07 56.6 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q61555 CHOYP_KC1D.3.3 m.61498 sp FBN2_MOUSE 37 500 260 20 139 606 1080 1556 6.78E-60 229 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q6DFU2 CHOYP_NS1BP.1.2 m.5710 sp NS1BP_XENLA 35.338 133 83 3 1 133 501 630 6.78E-20 87.8 NS1BP_XENLA reviewed Influenza virus NS1A-binding protein homolog (NS1-BP) (NS1-binding protein homolog) ivns1abp Xenopus laevis (African clawed frog) 638 0 GO:0005634; GO:0005737; GO:0015629 0 0 0 PF07707;PF00651;PF01344; Q6R7G0 CHOYP_LOC100374064.1.4 m.7391 sp Y068_OSHVF 27.374 179 105 5 1 154 514 692 6.78E-09 60.8 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q7T3N1 CHOYP_RL15.2.3 m.57280 sp RL15_MYLPI 79.798 99 20 0 1 99 17 115 6.78E-52 164 RL15_MYLPI reviewed 60S ribosomal protein L15 rpl15 Mylopharyngodon piceus (Black carp) (Leuciscus piceus) 204 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00827; Q7Z0T3 CHOYP_TRIADDRAFT_32712.4.4 m.44519 sp TEMPT_APLCA 42.969 128 56 6 96 219 6 120 6.78E-21 87.8 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q9U6D3 CHOYP_BRAFLDRAFT_115029.2.2 m.33798 sp CALM_MYXGL 39.583 144 84 3 15 156 4 146 6.78E-26 99 CALM_MYXGL reviewed Calmodulin (CaM) 0 Myxine glutinosa (Atlantic hagfish) 149 0 GO:0005509 0 0 0 PF13499; Q9VWE0 CHOYP_DVIR_GJ15619.1.2 m.59398 sp DOME_DROME 22.241 607 386 29 22 589 23 582 6.78E-11 70.5 DOME_DROME reviewed Cytokine receptor (Protein domeless) dome CG14226 Drosophila melanogaster (Fruit fly) 1282 "blastoderm segmentation [GO:0007350]; border follicle cell migration [GO:0007298]; compound eye morphogenesis [GO:0001745]; defense response to Gram-negative bacterium [GO:0050829]; epithelial cell fate determination, open tracheal system [GO:0007425]; epithelium development [GO:0060429]; germarium-derived egg chamber formation [GO:0007293]; hindgut morphogenesis [GO:0007442]; immune response [GO:0006955]; JAK-STAT cascade [GO:0007259]; locomotor rhythm [GO:0045475]; long-term memory [GO:0007616]; negative regulation of innate immune response [GO:0045824]; open tracheal system development [GO:0007424]; positive regulation of cell proliferation [GO:0008284]; regulation of apoptotic process [GO:0042981]" GO:0001745; GO:0004888; GO:0005622; GO:0005886; GO:0006955; GO:0007259; GO:0007293; GO:0007298; GO:0007350; GO:0007424; GO:0007425; GO:0007442; GO:0007616; GO:0008284; GO:0016021; GO:0016324; GO:0016327; GO:0042981; GO:0045475; GO:0045824; GO:0046982; GO:0050829; GO:0060429 0 0 0 PF00041; B3EWY9 CHOYP_contig_002327 m.2549 sp MLP_ACRMI 28.969 1077 586 46 299 1301 394 1365 6.79E-95 345 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O75581 CHOYP_LOC578599.8.8 m.57682 sp LRP6_HUMAN 26.112 877 561 27 113 949 100 929 6.79E-79 290 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; P18052 CHOYP_PTPRK.1.20 m.540 sp PTPRA_MOUSE 27.143 210 141 5 8 210 623 827 6.79E-19 87.8 PTPRA_MOUSE reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28) Ptpra Lrp Ptpa Mus musculus (Mouse) 829 insulin receptor signaling pathway [GO:0008286]; protein phosphorylation [GO:0006468] GO:0004725; GO:0006468; GO:0008286; GO:0016021; GO:0043235; GO:0070062 0 0 0 PF00102; P23286 CHOYP_CALM.14.50 m.29267 sp CALM_CANAX 38 150 91 2 1 149 1 149 6.79E-33 116 CALM_CANAX reviewed Calmodulin (CaM) CMD1 Candida albicans (Yeast) 149 0 GO:0005509 0 0 0 PF13499; P34410 CHOYP_LOC100903626.1.1 m.47854 sp TWK7_CAEEL 27.635 351 197 9 136 475 156 460 6.79E-32 131 TWK7_CAEEL reviewed TWiK family of potassium channels protein 7 twk-7 twk-8 F22B7.7 Caenorhabditis elegans 557 potassium ion transmembrane transport [GO:0071805]; stabilization of membrane potential [GO:0030322] GO:0005887; GO:0022841; GO:0030322; GO:0071805 0 0 0 PF07885; Q13227 CHOYP_LOC101021639.1.1 m.58988 sp GPS2_HUMAN 35.103 339 154 13 4 321 3 296 6.79E-22 98.2 GPS2_HUMAN reviewed G protein pathway suppressor 2 (GPS-2) GPS2 Homo sapiens (Human) 327 cell cycle [GO:0007049]; inactivation of MAPK activity [GO:0000188]; JNK cascade [GO:0007254]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122] GO:0000122; GO:0000188; GO:0003714; GO:0005095; GO:0005654; GO:0007049; GO:0007254; GO:0017053; GO:0046329 0 0 0 PF15991; Q14678 CHOYP_LOC100218754.1.1 m.60778 sp KANK1_HUMAN 43.152 387 185 8 1171 1533 973 1348 6.79E-76 281 KANK1_HUMAN reviewed KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein) KANK1 ANKRD15 KANK KIAA0172 Homo sapiens (Human) 1352 "negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell migration [GO:0030336]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of lamellipodium morphogenesis [GO:2000393]; negative regulation of neuron projection development [GO:0010977]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of ruffle assembly [GO:1900028]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of wound healing [GO:0090303]; regulation of establishment of cell polarity [GO:2000114]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0005886; GO:0006351; GO:0006355; GO:0008013; GO:0010977; GO:0030177; GO:0030336; GO:0030837; GO:0032587; GO:0035024; GO:0035413; GO:0046627; GO:0090303; GO:1900025; GO:1900028; GO:2000114; GO:2000393 0 0 0 PF12796;PF12075; Q1L673 CHOYP_ISCW_ISCW009328.2.2 m.65633 sp VDRB_DANRE 31.043 422 229 13 100 482 22 420 6.79E-56 194 VDRB_DANRE reviewed "Vitamin D3 receptor B (VDR-B) (1,25-dihydroxyvitamin D3 receptor B) (Nuclear receptor subfamily 1 group I member 1-B)" vdrb nr1i1b gb:dq017633 Danio rerio (Zebrafish) (Brachydanio rerio) 422 "heart jogging [GO:0003146]; heart looping [GO:0001947]; transcription, DNA-templated [GO:0006351]" GO:0001947; GO:0003146; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0008434; GO:0043565 0 0 0 PF00104;PF00105; Q5PQP2 CHOYP_RCAS1.1.1 m.15137 sp RCAS1_RAT 35.814 215 110 11 11 208 10 213 6.79E-27 105 RCAS1_RAT reviewed Receptor-binding cancer antigen expressed on SiSo cells (Estrogen receptor-binding fragment-associated gene 9 protein) Ebag9 Rattus norvegicus (Rat) 213 apoptotic process [GO:0006915] GO:0000139; GO:0006915; GO:0016021; GO:0030141 0 0 0 0 Q7SZ73 CHOYP_FXL15.1.3 m.12103 sp FXL15_XENLA 45.882 85 46 0 12 96 186 270 6.79E-19 82.4 FXL15_XENLA reviewed F-box/LRR-repeat protein 15 fbxl15 Xenopus laevis (African clawed frog) 292 bone mineralization [GO:0030282]; dorsal/ventral pattern formation [GO:0009953]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of BMP signaling pathway [GO:0030513]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000086; GO:0005737; GO:0009953; GO:0016567; GO:0019005; GO:0030282; GO:0030513; GO:0031146 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00646;PF13516; Q91618 CHOYP_LOC100376881.1.1 m.49381 sp PMYT1_XENLA 45.991 424 219 5 7 421 16 438 6.79E-117 359 PMYT1_XENLA reviewed Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) pkmyt1 myt1 Xenopus laevis (African clawed frog) 548 cell cycle [GO:0007049]; negative regulation of phosphatase activity [GO:0010923] GO:0000139; GO:0004674; GO:0005524; GO:0005789; GO:0007049; GO:0010923; GO:0046872 0 0 0 PF00069; Q96AY3 CHOYP_FKBP9.1.1 m.7408 sp FKB10_HUMAN 36.522 115 66 5 47 160 265 373 6.79E-10 62.4 FKB10_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase FKBP10 (PPIase FKBP10) (EC 5.2.1.8) (65 kDa FK506-binding protein) (65 kDa FKBP) (FKBP-65) (FK506-binding protein 10) (FKBP-10) (Immunophilin FKBP65) (Rotamase) FKBP10 FKBP65 PSEC0056 Homo sapiens (Human) 582 chaperone-mediated protein folding [GO:0061077] GO:0003755; GO:0005509; GO:0005528; GO:0005788; GO:0005789; GO:0061077 0 0 0 PF13202;PF00254; Q9H8H3 CHOYP_LOC100557412.1.1 m.30905 sp MET7A_HUMAN 39.234 209 123 4 50 256 38 244 6.79E-44 151 MET7A_HUMAN reviewed Methyltransferase-like protein 7A (EC 2.1.1.-) (Protein AAM-B) METTL7A PRO0066 UNQ1902/PRO4348 Homo sapiens (Human) 244 methylation [GO:0032259] GO:0005737; GO:0005783; GO:0005811; GO:0008757; GO:0016020; GO:0032259; GO:0070062 0 0 0 PF08241; A8E7I5 CHOYP_BRAFLDRAFT_122687.1.1 m.47712 sp TTC36_DANRE 55.249 181 77 1 9 185 3 183 6.80E-62 192 TTC36_DANRE reviewed Tetratricopeptide repeat protein 36 (TPR repeat protein 36) ttc36 si:rp71-52f21.2 zgc:103600 Danio rerio (Zebrafish) (Brachydanio rerio) 187 cilium assembly [GO:0042384]; determination of heart left/right asymmetry [GO:0061371]; otolith morphogenesis [GO:0032474] GO:0032474; GO:0042384; GO:0061371 0 0 0 0 P07207 CHOYP_LOC100367084.14.22 m.52850 sp NOTCH_DROME 48.913 92 46 1 143 233 1183 1274 6.80E-16 85.9 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P11387 CHOYP_TOP1.2.5 m.29160 sp TOP1_HUMAN 37.168 339 147 6 45 317 427 765 6.80E-57 199 TOP1_HUMAN reviewed DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) TOP1 Homo sapiens (Human) 765 chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; protein sumoylation [GO:0016925]; response to drug [GO:0042493]; viral process [GO:0016032] GO:0000932; GO:0001046; GO:0003677; GO:0003682; GO:0003917; GO:0003918; GO:0005634; GO:0005654; GO:0005730; GO:0006260; GO:0006265; GO:0006338; GO:0007059; GO:0007623; GO:0012501; GO:0016032; GO:0016310; GO:0016925; GO:0031298; GO:0032922; GO:0040016; GO:0042493; GO:0043204; GO:0044822 0 0 0 PF14370;PF01028;PF02919; Q24423 CHOYP_NOC.1.1 m.63030 sp NOC_DROME 35.294 289 130 13 218 485 283 535 6.80E-27 117 NOC_DROME reviewed Zinc finger protein Noc (Zinc finger protein NocA) noc nocA CG4491 Drosophila melanogaster (Fruit fly) 537 "brain development [GO:0007420]; cell proliferation [GO:0008283]; compound eye photoreceptor fate commitment [GO:0001752]; eye-antennal disc development [GO:0035214]; inter-male aggressive behavior [GO:0002121]; leg disc development [GO:0035218]; negative regulation of gene expression [GO:0010629]; Notch signaling pathway [GO:0007219]; ocellus development [GO:0008056]; open tracheal system development [GO:0007424]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; terminal branching, open tracheal system [GO:0007430]; wing disc development [GO:0035220]" GO:0001752; GO:0002121; GO:0003677; GO:0005634; GO:0006357; GO:0007219; GO:0007420; GO:0007424; GO:0007430; GO:0008056; GO:0008283; GO:0010629; GO:0035214; GO:0035218; GO:0035220; GO:0046872 0 0 0 0 Q3T0W7 CHOYP_LOC100369330.1.1 m.48177 sp ATG12_BOVIN 57.522 113 36 1 27 127 28 140 6.80E-43 140 ATG12_BOVIN reviewed Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) ATG12 Bos taurus (Bovine) 140 autophagosome assembly [GO:0000045]; C-terminal protein lipidation [GO:0006501]; innate immune response [GO:0045087]; mitophagy [GO:0000422]; nucleophagy [GO:0044804] GO:0000045; GO:0000422; GO:0006501; GO:0019776; GO:0034045; GO:0034274; GO:0044804; GO:0045087 0 0 cd01612; PF04110; Q56K03 CHOYP_LOC100533291.5.7 m.34673 sp RL27A_BOVIN 76.087 138 32 1 1 137 1 138 6.80E-73 217 RL27A_BOVIN reviewed 60S ribosomal protein L27a RPL27A Bos taurus (Bovine) 148 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00828; Q5NDE3 CHOYP_LOC101172435.1.1 m.1438 sp PMGT2_TETNG 34.719 481 286 12 51 508 68 543 6.80E-94 300 PMGT2_TETNG reviewed "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2) (EC 2.4.1.-) (Extracellular O-linked N-acetylglucosamine transferase-like) (Glycosyltransferase-like domain-containing protein 2)" pomgnt2 ago61 gtdc2 GSTENG00012312001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 579 brain development [GO:0007420]; muscle fiber development [GO:0048747]; neuron migration [GO:0001764]; protein O-linked glycosylation [GO:0006493]; protein O-linked mannosylation [GO:0035269]; retina development in camera-type eye [GO:0060041] GO:0001764; GO:0005783; GO:0005789; GO:0006493; GO:0007420; GO:0008375; GO:0016021; GO:0035269; GO:0048747; GO:0060041 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q8NAT1}. 0 0 PF04577; Q96GP6 CHOYP_SCARF2.1.1 m.6044 sp SREC2_HUMAN 40.964 166 93 4 3 168 259 419 6.80E-28 112 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_255103.1.18 m.20653 sp TRIM2_MOUSE 25.316 158 92 5 12 159 515 656 6.80E-06 49.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9IA19 CHOYP_HXA1.1.1 m.7522 sp HXA1_HETFR 51.479 169 65 6 97 263 129 282 6.80E-40 144 HXA1_HETFR reviewed Homeobox protein Hox-A1 HOXA1 Heterodontus francisci (Horn shark) (Cestracion francisci) 326 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; Q9U3W6 CHOYP_NEMVEDRAFT_V1G218264.6.14 m.24585 sp MAB21_DROME 24.845 161 109 3 162 316 185 339 6.80E-08 58.5 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; A0A0R4IBK5 CHOYP_RN213.13.13 m.62190 sp R213A_DANRE 31.917 1106 652 28 33 1112 3063 4093 6.81E-147 492 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 E9Q557 CHOYP_TVAG_198570.6.8 m.57052 sp DESP_MOUSE 24.066 482 279 13 336 792 1391 1810 6.81E-06 54.3 DESP_MOUSE reviewed Desmoplakin (DP) Dsp Mus musculus (Mouse) 2883 adherens junction organization [GO:0034332]; bundle of His cell-Purkinje myocyte adhesion involved in cell communication [GO:0086073]; desmosome organization [GO:0002934]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; protein localization to adherens junction [GO:0071896]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; single organismal cell-cell adhesion [GO:0016337]; skin development [GO:0043588]; ventricular compact myocardium morphogenesis [GO:0003223]; wound healing [GO:0042060] GO:0001533; GO:0002934; GO:0003223; GO:0005080; GO:0005198; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0005916; GO:0014704; GO:0016020; GO:0016323; GO:0016337; GO:0018149; GO:0030057; GO:0030216; GO:0030674; GO:0034332; GO:0042060; GO:0043588; GO:0044822; GO:0045104; GO:0045109; GO:0070062; GO:0071896; GO:0086073; GO:0086091; GO:0097110; GO:0098911 0 0 0 PF00681; O75382 CHOYP_BRAFLDRAFT_69765.18.23 m.59603 sp TRIM3_HUMAN 26.667 105 73 2 167 267 622 726 6.81E-06 51.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P07996 CHOYP_SSPO.9.14 m.39944 sp TSP1_HUMAN 43.363 113 59 2 25 133 436 547 6.81E-21 93.6 TSP1_HUMAN reviewed Thrombospondin-1 THBS1 TSP TSP1 Homo sapiens (Human) 1170 activation of MAPK activity [GO:0000187]; behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; cell cycle arrest [GO:0007050]; cell migration [GO:0016477]; cellular response to heat [GO:0034605]; chronic inflammatory response [GO:0002544]; engulfment of apoptotic cell [GO:0043652]; extracellular matrix organization [GO:0030198]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [GO:0002581]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cGMP-mediated signaling [GO:0010754]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of dendritic cell antigen processing and presentation [GO:0002605]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of nitric oxide mediated signal transduction [GO:0010751]; negative regulation of plasma membrane long-chain fatty acid transport [GO:0010748]; negative regulation of plasminogen activation [GO:0010757]; peptide cross-linking [GO:0018149]; platelet degranulation [GO:0002576]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of chemotaxis [GO:0050921]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of phosphorylation [GO:0042327]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transforming growth factor beta1 production [GO:0032914]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive regulation of translation [GO:0045727]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; protein O-linked fucosylation [GO:0036066]; regulation of cGMP metabolic process [GO:0030823]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; response to magnesium ion [GO:0032026]; response to progesterone [GO:0032570]; response to unfolded protein [GO:0006986]; sprouting angiogenesis [GO:0002040] GO:0000187; GO:0001666; GO:0001786; GO:0001937; GO:0001948; GO:0001953; GO:0001968; GO:0002040; GO:0002544; GO:0002576; GO:0002581; GO:0002605; GO:0005178; GO:0005509; GO:0005576; GO:0005577; GO:0005615; GO:0005783; GO:0005788; GO:0006954; GO:0006955; GO:0006986; GO:0007050; GO:0007155; GO:0008201; GO:0009749; GO:0009897; GO:0009986; GO:0010595; GO:0010596; GO:0010748; GO:0010751; GO:0010754; GO:0010757; GO:0010759; GO:0010763; GO:0016477; GO:0016525; GO:0016529; GO:0017134; GO:0018149; GO:0030141; GO:0030169; GO:0030194; GO:0030198; GO:0030335; GO:0030511; GO:0030823; GO:0031012; GO:0031091; GO:0031093; GO:0032026; GO:0032570; GO:0032695; GO:0032914; GO:0034605; GO:0034976; GO:0036066; GO:0040037; GO:0042327; GO:0042493; GO:0042535; GO:0042802; GO:0043032; GO:0043066; GO:0043154; GO:0043236; GO:0043394; GO:0043536; GO:0043537; GO:0043652; GO:0045727; GO:0045766; GO:0048266; GO:0050431; GO:0050921; GO:0051592; GO:0051895; GO:0051897; GO:0051918; GO:0070051; GO:0070052; GO:0070062; GO:1902043; GO:2000353; GO:2000379; GO:2001027; GO:2001237 0 0 0 PF00090;PF02412;PF05735;PF00093; P08132 CHOYP_ANXA4.1.2 m.19913 sp ANXA4_PIG 50.645 310 152 1 8 317 6 314 6.81E-98 294 ANXA4_PIG reviewed Annexin A4 (35-beta calcimedin) (Annexin IV) (Annexin-4) (Chromobindin-4) (Endonexin I) (Lipocortin IV) (P32.5) (PP4-X) (Placental anticoagulant protein II) (PAP-II) (Protein II) ANXA4 ANX4 Sus scrofa (Pig) 319 0 GO:0005509; GO:0005544 0 0 0 PF00191; Q0E908 CHOYP_LOC100868040.1.1 m.43728 sp HIL_DROME 32.491 791 425 24 15 716 6 776 6.81E-119 382 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q4ZJM9 CHOYP_C1QL2.18.32 m.28959 sp C1QL4_MOUSE 33.051 118 72 4 184 298 124 237 6.81E-12 68.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5FVB0 CHOYP_ATXN10.1.1 m.33209 sp ATX10_XENTR 30.864 405 252 10 83 476 90 477 6.81E-46 169 ATX10_XENTR reviewed Ataxin-10 (Spinocerebellar ataxia type 10 protein homolog) atxn10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 485 0 GO:0048471 0 0 0 PF09759; Q5REC6 CHOYP_GRL1A.1.1 m.64516 sp GRL1A_PONAB 26.178 382 211 13 28 380 15 354 6.81E-13 72.8 GRL1A_PONAB reviewed DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) POLR2M GRINL1A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 367 0 GO:0003899; GO:0016591 0 0 0 PF15328; Q7LHG5 CHOYP_CRE_16387.1.1 m.10429 sp YI31B_YEAST 45.902 122 64 1 278 399 612 731 6.81E-22 101 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q7ZV82 CHOYP_LOC100373506.7.8 m.50106 sp RL27_DANRE 80.328 122 24 0 17 138 1 122 6.81E-68 204 RL27_DANRE reviewed 60S ribosomal protein L27 rpl27 zgc:56171 Danio rerio (Zebrafish) (Brachydanio rerio) 136 erythrocyte differentiation [GO:0030218]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625; GO:0030218 0 0 0 PF00467;PF01777; Q86TC9 CHOYP_TSP_09716.1.2 m.30803 sp MYPN_HUMAN 25.094 267 159 5 8 266 300 533 6.81E-18 87.4 MYPN_HUMAN reviewed Myopalladin (145 kDa sarcomeric protein) MYPN MYOP Homo sapiens (Human) 1320 sarcomere organization [GO:0045214] GO:0005634; GO:0008092; GO:0017124; GO:0030018; GO:0031674; GO:0045214; GO:0051371 0 0 0 PF07679; Q8N9W6 CHOYP_LOC100892519.1.4 m.2588 sp BOLL_HUMAN 50 200 77 9 45 242 22 200 6.81E-48 165 BOLL_HUMAN reviewed Protein boule-like BOLL BOULE Homo sapiens (Human) 283 cell differentiation [GO:0030154]; meiotic nuclear division [GO:0007126]; multicellular organism development [GO:0007275]; positive regulation of translational initiation [GO:0045948]; spermatogenesis [GO:0007283] GO:0000166; GO:0003723; GO:0005737; GO:0007126; GO:0007275; GO:0007283; GO:0008494; GO:0030154; GO:0045948 0 0 0 PF00076; Q8TDP1 CHOYP_LOC100377204.1.1 m.18920 sp RNH2C_HUMAN 26.812 138 75 2 15 131 27 159 6.81E-16 73.2 RNH2C_HUMAN reviewed Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) RNASEH2C AYP1 Homo sapiens (Human) 164 RNA catabolic process [GO:0006401] GO:0004523; GO:0005634; GO:0006401; GO:0032299 0 0 cd09271; PF08615; Q8UVC3 CHOYP_INVS.3.6 m.29719 sp INVS_CHICK 59.791 383 151 2 1 380 255 637 6.81E-160 491 INVS_CHICK reviewed Inversin INVS Gallus gallus (Chicken) 1106 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005737; GO:0005856; GO:0007275; GO:0016055 0 0 0 PF12796;PF00612; Q921X9 CHOYP_LOC100372340.2.3 m.43098 sp PDIA5_MOUSE 44.012 334 174 7 1 328 174 500 6.81E-80 263 PDIA5_MOUSE reviewed Protein disulfide-isomerase A5 (EC 5.3.4.1) (Protein disulfide isomerase-related protein) Pdia5 Pdir Mus musculus (Mouse) 517 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005783; GO:0005788; GO:0006457; GO:0034976; GO:0045454 0 0 0 PF00085; Q9R0T8 CHOYP_IKKE.1.1 m.13278 sp IKKE_MOUSE 41.304 92 50 1 10 101 2 89 6.81E-15 73.6 IKKE_MOUSE reviewed Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) Ikbke Ikke Ikki Mus musculus (Mouse) 717 cellular response to virus [GO:0098586]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein homooligomerization [GO:0051260]; protein phosphorylation [GO:0006468]; response to interferon-beta [GO:0035456]; response to type I interferon [GO:0034340] GO:0004704; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0008384; GO:0008630; GO:0016605; GO:0031625; GO:0031966; GO:0034340; GO:0035456; GO:0036435; GO:0043123; GO:0051260; GO:0098586 0 0 0 PF00069; Q9R0W9 CHOYP_LOC101159658.1.1 m.62104 sp ACHA6_MOUSE 28.032 371 237 12 39 398 43 394 6.81E-35 138 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9XWB9 CHOYP_CRE_19773.1.1 m.55805 sp BAT36_CAEEL 32.061 131 80 3 28 157 159 281 6.81E-11 64.3 BAT36_CAEEL reviewed BTB and MATH domain-containing protein 36 bath-36 Y75B12B.4 Caenorhabditis elegans 320 0 0 0 0 0 PF00651;PF00917; B4JSC2 CHOYP_LOC100123890.1.1 m.11450 sp FOXO_DROGR 59.45 291 83 9 10 278 30 307 6.82E-95 308 FOXO_DROGR reviewed Forkhead box protein O foxo GH22274 Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) 630 "cell cycle [GO:0007049]; cell differentiation [GO:0030154]; glucose homeostasis [GO:0042593]; multicellular organism aging [GO:0010259]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007049; GO:0008285; GO:0010259; GO:0019216; GO:0030154; GO:0030308; GO:0042593; GO:0043565; GO:0046627 0 0 0 PF00250; D2GXS7 CHOYP_BRAFLDRAFT_69765.5.23 m.32460 sp TRIM2_AILME 25.292 257 177 7 169 414 492 744 6.82E-11 67.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75123 CHOYP_ZN468.1.1 m.35905 sp ZN623_HUMAN 40.426 141 79 2 530 670 260 395 6.82E-25 112 ZN623_HUMAN reviewed Zinc finger protein 623 ZNF623 KIAA0628 Homo sapiens (Human) 536 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; P11833 CHOYP_LOC373275.6.7 m.57857 sp TBB_PARLI 77.477 111 24 1 1 111 1 110 6.82E-58 187 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P28021 CHOYP_CSK2B.1.1 m.37285 sp CSK2B_XENLA 92.925 212 15 0 1 212 1 212 6.82E-152 423 CSK2B_XENLA reviewed Casein kinase II subunit beta (CK II beta) (Phosvitin) csnk2b Xenopus laevis (African clawed frog) 215 Wnt signaling pathway [GO:0016055] GO:0005956; GO:0016055; GO:0019887; GO:0046872 0 0 0 PF01214; Q00962 CHOYP_LOC100635540.1.7 m.10042 sp POL_CAMVN 24.549 277 180 6 9 273 420 679 6.82E-06 51.2 POL_CAMVN reviewed Enzymatic polyprotein [Includes: Aspartic protease (EC 3.4.23.-); Endonuclease; Reverse transcriptase (EC 2.7.7.49)] ORF V Cauliflower mosaic virus (strain NY8153) (CaMV) 680 0 GO:0003964; GO:0004190; GO:0004519 0 0 0 PF02160;PF00078; Q0V8M0 CHOYP_LOC100489126.1.1 m.18822 sp KRI1_BOVIN 41.882 659 319 15 33 659 7 633 6.82E-145 446 KRI1_BOVIN reviewed Protein KRI1 homolog KRI1 Bos taurus (Bovine) 705 0 0 0 0 0 PF05178;PF12936; Q15428 CHOYP_PHUM_PHUM544530.1.1 m.38469 sp SF3A2_HUMAN 87.442 215 27 0 1 215 1 215 6.82E-124 367 SF3A2_HUMAN reviewed Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) SF3A2 SAP62 Homo sapiens (Human) 464 "mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of neuron projection development [GO:0010976]; RNA splicing [GO:0008380]" GO:0000389; GO:0000398; GO:0005654; GO:0005681; GO:0005686; GO:0006397; GO:0008270; GO:0008380; GO:0010976; GO:0016607; GO:0030532; GO:0044822; GO:0071004; GO:0071013 0 0 0 PF16835; Q503I2 CHOYP_TRI13.2.2 m.39439 sp TRI13_DANRE 21.509 265 170 7 11 275 50 276 6.82E-07 54.3 TRI13_DANRE reviewed Tripartite motif-containing 13 trim13 zgc:110578 Danio rerio (Zebrafish) (Brachydanio rerio) 404 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q575T0 CHOYP_LOC100909144.2.2 m.52417 sp CYGB1_ORYLA 30.208 96 67 0 44 139 16 111 6.82E-11 61.6 CYGB1_ORYLA reviewed Cytoglobin-1 cygb1 cygb-1 Oryzias latipes (Japanese rice fish) (Japanese killifish) 177 0 GO:0005344; GO:0005506; GO:0005737; GO:0019825; GO:0020037 0 0 0 PF00042; Q5UQ13 CHOYP_CLS_21530.1.1 m.30457 sp COLL2_MIMIV 43.695 341 183 3 38 369 148 488 6.82E-58 207 COLL2_MIMIV reviewed Collagen-like protein 2 MIMI_R196 Acanthamoeba polyphaga mimivirus (APMV) 1595 0 GO:0019012 0 0 0 PF01391; Q6NV34 CHOYP_DECR2.2.2 m.42782 sp DECR2_DANRE 47.674 86 40 1 21 101 3 88 6.82E-21 87.4 DECR2_DANRE reviewed "Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2)" decr2 si:ch211-153c20.5 zgc:85626 Danio rerio (Zebrafish) (Brachydanio rerio) 300 fatty acid metabolic process [GO:0006631] GO:0005777; GO:0006631; GO:0008670 0 0 0 0 Q96KG7 CHOYP_MEG11.23.25 m.60738 sp MEG10_HUMAN 35.772 246 132 11 183 416 431 662 6.82E-27 119 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q9BDB7 CHOYP_LOC100377780.2.11 m.37982 sp IF44L_MOUSE 31.28 211 143 1 1 209 225 435 6.82E-26 106 IF44L_MOUSE reviewed Interferon-induced protein 44-like [Cleaved into: Minor histocompatibility antigen HA-28 (HLA-HA28) (IFL8)] Ifi44l H28 Mus musculus (Mouse) 447 immune response [GO:0006955] GO:0005654; GO:0005737; GO:0006955 0 0 0 0 Q9H270 CHOYP_VPS11.1.3 m.2263 sp VPS11_HUMAN 68.75 64 19 1 42 104 864 927 6.82E-22 92 VPS11_HUMAN reviewed Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) VPS11 RNF108 PP3476 Homo sapiens (Human) 941 autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vesicle docking involved in exocytosis [GO:0006904] GO:0000166; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005776; GO:0006886; GO:0006904; GO:0006914; GO:0007032; GO:0007040; GO:0008270; GO:0008333; GO:0019904; GO:0019905; GO:0030136; GO:0030139; GO:0030674; GO:0030897; GO:0031647; GO:0031902; GO:0034058; GO:0035542; GO:1902115; GO:1903364; GO:1903955; GO:2000643 0 0 0 PF00637;PF12451; Q9H8W5 CHOYP_NAEGRDRAFT_64310.1.1 m.31680 sp TRI45_HUMAN 23.784 185 132 6 13 191 135 316 6.82E-06 51.2 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9VT65 CHOYP_contig_022851 m.26077 sp CANB_DROME 40.123 324 158 4 1 322 636 925 6.82E-72 242 CANB_DROME reviewed Calpain-B (EC 3.4.22.-) (Calcium-activated neutral proteinase B) (CANP B) [Cleaved into: Calpain-B catalytic subunit 1; Calpain-B catalytic subunit 2] CalpB CG8107 Drosophila melanogaster (Fruit fly) 925 border follicle cell migration [GO:0007298]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]; sensory perception of pain [GO:0019233] GO:0004198; GO:0005509; GO:0005737; GO:0006508; GO:0007298; GO:0016020; GO:0016540; GO:0019233 0 0 0 PF01067;PF00648; P0DMQ6 CHOYP_DHSO.2.2 m.29745 sp DHSO_CHICK 52.738 347 163 1 2 348 3 348 6.83E-140 404 DHSO_CHICK reviewed Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) SORD Gallus gallus (Chicken) 355 fructose biosynthetic process [GO:0046370]; fructose metabolic process [GO:0006000]; L-xylitol catabolic process [GO:0051160]; NADH oxidation [GO:0006116]; NADH regeneration [GO:0006735]; sorbitol biosynthetic process [GO:0006061]; sorbitol catabolic process [GO:0006062]; sperm motility [GO:0030317] GO:0003939; GO:0006000; GO:0006061; GO:0006062; GO:0006116; GO:0006735; GO:0008270; GO:0030317; GO:0031514; GO:0031966; GO:0032991; GO:0046370; GO:0046526; GO:0051160; GO:0051287; GO:0070062 0 0 0 PF08240;PF00107; P11831 CHOYP_LOC100370177.1.1 m.1755 sp SRF_HUMAN 43.631 369 167 10 50 408 133 470 6.83E-69 230 SRF_HUMAN reviewed Serum response factor (SRF) SRF Homo sapiens (Human) 508 angiogenesis involved in wound healing [GO:0060055]; associative learning [GO:0008306]; bicellular tight junction assembly [GO:0070830]; bronchus cartilage development [GO:0060532]; cardiac myofibril assembly [GO:0055003]; cardiac vascular smooth muscle cell differentiation [GO:0060947]; cell-matrix adhesion [GO:0007160]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to glucose stimulus [GO:0071333]; cellular senescence [GO:0090398]; developmental growth [GO:0048589]; dorsal aorta morphogenesis [GO:0035912]; epithelial cell-cell adhesion [GO:0090136]; epithelial structure maintenance [GO:0010669]; erythrocyte development [GO:0048821]; eyelid development in camera-type eye [GO:0061029]; face development [GO:0060324]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula formation [GO:0060347]; hematopoietic stem cell differentiation [GO:0060218]; hippocampus development [GO:0021766]; long-term memory [GO:0007616]; long term synaptic depression [GO:0060292]; lung morphogenesis [GO:0060425]; lung smooth muscle development [GO:0061145]; megakaryocyte development [GO:0035855]; mesoderm formation [GO:0001707]; morphogenesis of an epithelial sheet [GO:0002011]; mRNA transcription from RNA polymerase II promoter [GO:0042789]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of beta-amyloid clearance [GO:1900222]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894]; neuron development [GO:0048666]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; patterning of blood vessels [GO:0001569]; platelet activation [GO:0030168]; platelet formation [GO:0030220]; positive regulation of axon extension [GO:0045773]; positive regulation of cell differentiation [GO:0045597]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of transcription by glucose [GO:0046016]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003257]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; positive regulation of transcription via serum response element binding [GO:0010735]; positive thymic T cell selection [GO:0045059]; primitive streak formation [GO:0090009]; regulation of cell adhesion [GO:0030155]; regulation of smooth muscle cell differentiation [GO:0051150]; regulation of water loss via skin [GO:0033561]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; sarcomere organization [GO:0045214]; skin morphogenesis [GO:0043589]; stress fiber assembly [GO:0043149]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; thymus development [GO:0048538]; thyroid gland development [GO:0030878]; trachea cartilage development [GO:0060534]; transcription from RNA polymerase II promoter [GO:0006366]; trophectodermal cell differentiation [GO:0001829] GO:0000790; GO:0000978; GO:0001076; GO:0001077; GO:0001228; GO:0001569; GO:0001666; GO:0001707; GO:0001764; GO:0001829; GO:0001947; GO:0002011; GO:0002042; GO:0003257; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0005737; GO:0006366; GO:0007160; GO:0007507; GO:0007616; GO:0008134; GO:0008285; GO:0008306; GO:0009636; GO:0009725; GO:0010669; GO:0010735; GO:0010736; GO:0021766; GO:0022028; GO:0030155; GO:0030168; GO:0030220; GO:0030336; GO:0030878; GO:0031175; GO:0031490; GO:0033561; GO:0034097; GO:0035855; GO:0035912; GO:0042789; GO:0042803; GO:0043149; GO:0043589; GO:0045059; GO:0045214; GO:0045597; GO:0045773; GO:0045944; GO:0045987; GO:0046016; GO:0046716; GO:0048538; GO:0048589; GO:0048666; GO:0048821; GO:0051091; GO:0051150; GO:0051491; GO:0055003; GO:0060055; GO:0060218; GO:0060261; GO:0060292; GO:0060324; GO:0060347; GO:0060425; GO:0060532; GO:0060534; GO:0060947; GO:0061029; GO:0061145; GO:0070830; GO:0070878; GO:0071333; GO:0090009; GO:0090136; GO:0090398; GO:1900222; GO:1902894; GO:1902895 0 0 0 PF00319; P18106 CHOYP_FPS.2.2 m.65582 sp FER_DROME 47.978 371 187 4 1 366 943 1312 6.83E-110 352 FER_DROME reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) FER fps Fps85D HD-179 CG8874 Drosophila melanogaster (Fruit fly) 1325 "actin filament bundle assembly [GO:0051017]; axon guidance [GO:0007411]; dorsal closure [GO:0007391]; dorsal closure, amnioserosa morphology change [GO:0046664]; dorsal closure, elongation of leading edge cells [GO:0007394]; innate immune response [GO:0045087]; peptidyl-tyrosine autophosphorylation [GO:0038083]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]" GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005543; GO:0005886; GO:0005912; GO:0006468; GO:0007169; GO:0007391; GO:0007394; GO:0007411; GO:0019898; GO:0031234; GO:0038083; GO:0042127; GO:0045087; GO:0046664; GO:0051017 0 0 0 PF00611;PF07714;PF00017; P21525 CHOYP_contig_021702 m.24931 sp FOSLA_DROME 28.947 76 43 1 62 137 409 473 6.83E-06 47.8 FOSLA_DROME reviewed "Transcription factor kayak, isoforms A/B/F (AP-1) (Fos-related antigen) (Dfos) (dFra)" kay Fra CG15509 Drosophila melanogaster (Fruit fly) 755 "adult chitin-containing cuticle pigmentation [GO:0048085]; antimicrobial humoral response [GO:0019730]; border follicle cell migration [GO:0007298]; collateral sprouting of injured axon [GO:0048674]; compound eye development [GO:0048749]; dendrite morphogenesis [GO:0048813]; dorsal closure [GO:0007391]; embryo development [GO:0009790]; establishment of planar polarity [GO:0001736]; germ cell development [GO:0007281]; imaginal disc fusion, thorax closure [GO:0046529]; JNK cascade [GO:0007254]; locomotor rhythm [GO:0045475]; ovarian follicle cell migration [GO:0007297]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R3/R4 cell fate commitment [GO:0007464]; regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [GO:0031660]; response to wounding [GO:0009611]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; synaptic growth at neuromuscular junction [GO:0051124]; wing disc development [GO:0035220]; wound healing [GO:0042060]" GO:0000978; GO:0000981; GO:0001077; GO:0001736; GO:0003677; GO:0003700; GO:0005634; GO:0005667; GO:0005737; GO:0007254; GO:0007281; GO:0007297; GO:0007298; GO:0007391; GO:0007464; GO:0008134; GO:0009611; GO:0009790; GO:0016330; GO:0019730; GO:0031660; GO:0035220; GO:0042060; GO:0043565; GO:0045475; GO:0045944; GO:0046529; GO:0046982; GO:0048085; GO:0048674; GO:0048749; GO:0048813; GO:0051124; GO:0070491 0 0 0 PF00170; P26446 CHOYP_MP2K5.1.1 m.45312 sp PARP1_CHICK 32.178 202 109 7 8 194 11 199 6.83E-18 88.2 PARP1_CHICK reviewed Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) PARP1 ADPRT Gallus gallus (Chicken) 1011 ATP generation from poly-ADP-D-ribose [GO:1990966]; DNA ligation involved in DNA repair [GO:0051103]; lagging strand elongation [GO:0006273]; protein poly-ADP-ribosylation [GO:0070212] GO:0003677; GO:0003910; GO:0003950; GO:0005634; GO:0005737; GO:0006273; GO:0008270; GO:0051103; GO:0051287; GO:0070212; GO:1990966 0 0 0 PF00533;PF08063;PF00644;PF02877;PF05406;PF00645; Q07E41 CHOYP_CTTB2.2.2 m.21804 sp CTTB2_DASNO 40.351 114 56 1 1 102 1320 1433 6.83E-18 92.4 CTTB2_DASNO reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Dasypus novemcinctus (Nine-banded armadillo) 1665 0 GO:0005938; GO:0043197 0 0 0 PF00023;PF12796;PF09727; Q13393 CHOYP_LOC658196.2.2 m.26237 sp PLD1_HUMAN 34.694 196 113 4 47 228 41 235 6.83E-32 125 PLD1_HUMAN reviewed Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) PLD1 Homo sapiens (Human) 1074 cell motility [GO:0048870]; chemotaxis [GO:0006935]; inositol lipid-mediated signaling [GO:0048017]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; small GTPase mediated signal transduction [GO:0007264] GO:0000139; GO:0004630; GO:0005765; GO:0005768; GO:0005789; GO:0005794; GO:0006654; GO:0006935; GO:0007264; GO:0007265; GO:0016020; GO:0016042; GO:0016324; GO:0030139; GO:0031902; GO:0032534; GO:0035091; GO:0048017; GO:0048471; GO:0048870; GO:0070290 0 0 0 PF00169;PF00614;PF13091;PF00787; Q14162 CHOYP_LOC100554581.2.2 m.46823 sp SREC_HUMAN 37.195 164 99 3 8 171 239 398 6.83E-26 106 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q4V7M2 CHOYP_LOC100697247.2.2 m.56896 sp CRE2B_XENLA 47.077 325 168 3 7 331 9 329 6.83E-100 304 CRE2B_XENLA reviewed Cysteine-rich with EGF-like domain protein 2-B creld2-b Xenopus laevis (African clawed frog) 361 0 GO:0005509; GO:0005576; GO:0005783 0 0 0 PF11938;PF07645; Q6PDJ1 CHOYP_NEMVEDRAFT_V1G238894.9.11 m.62546 sp CAHD1_MOUSE 26.528 965 642 33 26 938 59 1008 6.83E-82 293 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q6PEC4 CHOYP_SKP1.1.1 m.40278 sp SKP1_RAT 85.89 163 22 1 25 186 1 163 6.83E-89 260 SKP1_RAT reviewed S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1) Skp1 Skp1a Rattus norvegicus (Rat) 163 protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005829; GO:0016567; GO:0019005; GO:0031146; GO:0031467 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01466;PF03931; Q6PFL6 CHOYP_CCD43.1.1 m.63636 sp CCD43_DANRE 42.786 201 108 4 1 196 14 212 6.83E-32 118 CCD43_DANRE reviewed Coiled-coil domain-containing protein 43 ccdc43 zgc:66277 Danio rerio (Zebrafish) (Brachydanio rerio) 213 0 0 0 0 0 0 Q6R5N8 CHOYP_TLR13.1.5 m.20156 sp TLR13_MOUSE 27.041 980 556 32 11 878 51 983 6.83E-57 215 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q8TE59 CHOYP_LOC100677605.1.1 m.51683 sp ATS19_HUMAN 31.481 108 66 4 1 106 531 632 6.83E-06 52.4 ATS19_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAM-TS 19) (ADAM-TS19) (ADAMTS-19) (EC 3.4.24.-) ADAMTS19 Homo sapiens (Human) 1207 0 GO:0004222; GO:0005578; GO:0008270 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q8WWF8 CHOYP_LOC100637812.1.1 m.1303 sp CAPSL_HUMAN 51.852 189 89 1 13 201 22 208 6.83E-60 189 CAPSL_HUMAN reviewed Calcyphosin-like protein CAPSL Homo sapiens (Human) 208 0 GO:0005509; GO:0005737 0 0 0 PF13499; Q90YI8 CHOYP_LOC101175459.1.1 m.62303 sp TAL1_TAKRU 74.194 62 16 0 149 210 205 266 6.83E-26 107 TAL1_TAKRU reviewed T-cell acute lymphocytic leukemia protein 1 (TAL-1) (FrSCL) (Stem cell protein) tal1 scl Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 371 "angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; definitive hemopoiesis [GO:0060216]; endocardium formation [GO:0060214]; erythrocyte differentiation [GO:0030218]; hemangioblast cell differentiation [GO:0060217]; hematopoietic stem cell differentiation [GO:0060218]; myeloid cell differentiation [GO:0030099]; primitive hemopoiesis [GO:0060215]; transcription, DNA-templated [GO:0006351]; vasculogenesis [GO:0001570]" GO:0000977; GO:0000981; GO:0001525; GO:0001570; GO:0003677; GO:0005634; GO:0006351; GO:0030099; GO:0030218; GO:0048844; GO:0060214; GO:0060215; GO:0060216; GO:0060217; GO:0060218 0 0 0 PF00010; Q9CR40 CHOYP_NEMVEDRAFT_V1G120526.2.5 m.2248 sp KLH28_MOUSE 28.571 140 95 4 11 147 15 152 6.83E-08 59.3 KLH28_MOUSE reviewed Kelch-like protein 28 (BTB/POZ domain-containing protein 5) Klhl28 Btbd5 Mus musculus (Mouse) 571 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0031463; GO:0042787 0 0 0 PF07707;PF00651;PF01344; Q9D0C1 CHOYP_LOC100374633.1.2 m.21989 sp RN115_MOUSE 38.356 292 144 7 30 299 19 296 6.83E-59 193 RN115_MOUSE reviewed E3 ubiquitin-protein ligase RNF115 (EC 6.3.2.-) (RING finger protein 115) (Rabring 7) (Zinc finger protein 364) Rnf115 Zfp364 Znf364 Mus musculus (Mouse) 305 negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0042059; GO:0042787; GO:0043161; GO:0043162; GO:0051865; GO:0061630; GO:0070534; GO:0070936 "PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:17462600, ECO:0000269|PubMed:23418353}." 0 0 PF13639; Q9VUX2 CHOYP_BRAFLDRAFT_120990.13.18 m.60039 sp MIB_DROME 42.857 70 32 2 137 200 246 313 6.83E-09 60.1 MIB_DROME reviewed E3 ubiquitin-protein ligase mind-bomb (EC 6.3.2.-) (Mind bomb homolog) (D-mib) mib1 mind-bomb CG5841 Drosophila melanogaster (Fruit fly) 1226 endocytosis [GO:0006897]; lateral inhibition [GO:0046331]; Notch signaling pathway [GO:0007219]; positive regulation of Notch signaling pathway [GO:0045747]; protein localization [GO:0008104]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of Notch signaling pathway [GO:0008593]; sensory organ development [GO:0007423] GO:0000209; GO:0004842; GO:0005737; GO:0005829; GO:0006897; GO:0007219; GO:0007423; GO:0008104; GO:0008270; GO:0008593; GO:0016567; GO:0016874; GO:0045179; GO:0045747; GO:0046331; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; A8MV24 CHOYP_LOC100367787.1.1 m.52250 sp CQ098_HUMAN 45.39 141 77 0 56 196 6 146 6.84E-37 129 CQ098_HUMAN reviewed Uncharacterized protein C17orf98 C17orf98 Homo sapiens (Human) 154 0 0 0 0 0 PF15075; B6RSP1 CHOYP_LOC593558.4.4 m.54253 sp PKHA7_DANRE 38.662 269 125 5 12 250 1 259 6.84E-49 195 PKHA7_DANRE reviewed Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7) (Heart adapter protein 1) plekha7 hadp1 Danio rerio (Zebrafish) (Brachydanio rerio) 1197 cardiac muscle cell differentiation [GO:0055007]; epithelial cell-cell adhesion [GO:0090136]; regulation of heart contraction [GO:0008016]; zonula adherens maintenance [GO:0045218] GO:0005737; GO:0005813; GO:0005915; GO:0008016; GO:0045218; GO:0055007; GO:0070097; GO:0090136 0 0 0 PF00169;PF00397; O75208 CHOYP_COQ9.1.2 m.4620 sp COQ9_HUMAN 38.793 116 55 2 1 113 204 306 6.84E-21 89 COQ9_HUMAN reviewed "Ubiquinone biosynthesis protein COQ9, mitochondrial" COQ9 C16orf49 HSPC326 PSEC0129 Homo sapiens (Human) 318 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; ubiquinone biosynthetic process [GO:0006744]" GO:0005739; GO:0005743; GO:0006120; GO:0006744; GO:0008289; GO:0042803 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000250|UniProtKB:Q8K1Z0}. 0 0 PF08511; O75581 CHOYP_LOC578656.8.15 m.42294 sp LRP6_HUMAN 26.901 855 580 23 117 951 100 929 6.84E-88 316 LRP6_HUMAN reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) LRP6 Homo sapiens (Human) 1613 "axis elongation involved in somitogenesis [GO:0090245]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; canonical Wnt signaling pathway involved in regulation of cell proliferation [GO:0044340]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; midbrain dopaminergic neuron differentiation [GO:1904948]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; response to peptide hormone [GO:0043434]; single organismal cell-cell adhesion [GO:0016337]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001843; GO:0001933; GO:0003344; GO:0005041; GO:0005102; GO:0005109; GO:0005576; GO:0005783; GO:0005829; GO:0005886; GO:0006469; GO:0007204; GO:0007268; GO:0009880; GO:0009986; GO:0014029; GO:0014033; GO:0016021; GO:0016055; GO:0016337; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021987; GO:0030917; GO:0031410; GO:0031901; GO:0034185; GO:0034392; GO:0035261; GO:0042475; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043235; GO:0043434; GO:0044332; GO:0044335; GO:0044340; GO:0045202; GO:0045787; GO:0045893; GO:0045944; GO:0051091; GO:0060021; GO:0060026; GO:0060059; GO:0060070; GO:0060325; GO:0060535; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090090; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1904886; GO:1904928; GO:1904948; GO:1904953; GO:1990851; GO:1990909; GO:2000055 0 0 0 PF00057;PF00058; P10155 CHOYP_RO60.4.6 m.53140 sp RO60_HUMAN 42.727 550 293 9 14 559 2 533 6.84E-141 421 RO60_HUMAN reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) TROVE2 RO60 SSA2 Homo sapiens (Human) 538 cilium morphogenesis [GO:0060271]; immune system development [GO:0002520]; response to UV [GO:0009411]; smoothened signaling pathway [GO:0007224]; transcription from RNA polymerase III promoter [GO:0006383] GO:0002520; GO:0003723; GO:0005634; GO:0005737; GO:0006383; GO:0007224; GO:0009411; GO:0030529; GO:0030620; GO:0046872; GO:0060271 0 0 0 PF05731; P23468 CHOYP_LOC100635116.1.5 m.14782 sp PTPRD_HUMAN 30.172 580 367 11 475 1026 1337 1906 6.84E-73 268 PTPRD_HUMAN reviewed Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) PTPRD Homo sapiens (Human) 1912 chemical synaptic transmission [GO:0007268]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron differentiation [GO:0030182]; phosphate-containing compound metabolic process [GO:0006796]; positive regulation of dendrite morphogenesis [GO:0050775]; presynaptic membrane assembly [GO:0097105]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0005001; GO:0005102; GO:0005886; GO:0005887; GO:0006470; GO:0006796; GO:0007157; GO:0007185; GO:0007268; GO:0030182; GO:0050775; GO:0050839; GO:0070062; GO:0097105 0 0 0 PF00041;PF07679;PF00102; Q07263 CHOYP_BM1_48815.1.1 m.58397 sp ACHA3_BOVIN 36.659 461 271 7 32 474 25 482 6.84E-101 314 ACHA3_BOVIN reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Bos taurus (Bovine) 495 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; nervous system development [GO:0007399]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0007399; GO:0015464; GO:0030054; GO:0035094; GO:0035095; GO:0045211; GO:0060084; GO:0098655 0 0 0 PF02931;PF02932; Q0VAA2 CHOYP_LOC100372392.1.8 m.6461 sp LR74A_HUMAN 29.343 426 291 7 88 509 64 483 6.84E-45 169 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q38PU3 CHOYP_GRIK2.3.3 m.55328 sp GRIK2_MACFA 36.015 547 307 11 255 771 304 837 6.84E-100 333 GRIK2_MACFA reviewed "Glutamate receptor ionotropic, kainate 2 (GluK2) (Glutamate receptor 6) (GluR-6) (GluR6)" GRIK2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 908 0 GO:0004970; GO:0005234; GO:0016021; GO:0030054; GO:0030424; GO:0043197; GO:0045211 0 0 0 PF01094;PF00060;PF10613; Q4FZX0 CHOYP_LCHN.1.2 m.59462 sp LCHN_XENLA 60.154 389 152 1 78 463 46 434 6.84E-159 459 LCHN_XENLA reviewed Protein LCHN lchn Xenopus laevis (African clawed frog) 434 0 0 0 0 0 PF09804; Q4P9K9 CHOYP_PHUM_PHUM073200.2.2 m.52442 sp CHS8_USTMA 26.111 360 182 12 688 1031 1431 1722 6.84E-22 107 CHS8_USTMA reviewed Chitin synthase 8 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 8) (Myosin chitin synthase 1) CHS8 MCS1 UMAG_03204 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 2005 cell wall organization [GO:0071555] GO:0003677; GO:0003774; GO:0004100; GO:0005524; GO:0005886; GO:0016021; GO:0016459; GO:0030659; GO:0071555 0 0 0 PF00173;PF08766;PF00063; Q5RAF1 CHOYP_BRAFLDRAFT_78075.1.1 m.55813 sp GL1D1_PONAB 35.86 343 215 4 5 346 3 341 6.84E-72 230 GL1D1_PONAB reviewed Glycosyltransferase 1 domain-containing protein 1 (EC 2.4.-.-) GLT1D1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 346 0 GO:0005576; GO:0016757 0 0 0 PF00534; Q5RDZ2 CHOYP_LOC100374307.1.1 m.29504 sp CRYL1_PONAB 45.659 311 165 3 5 313 9 317 6.84E-103 307 CRYL1_PONAB reviewed Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH) CRYL1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 319 fatty acid metabolic process [GO:0006631] GO:0003857; GO:0005730; GO:0005794; GO:0005829; GO:0005886; GO:0006631; GO:0050104; GO:0070062; GO:0070403 0 0 0 PF00725;PF02737; Q5UCA8 CHOYP_ACTP1.1.1 m.30455 sp BRYP_PHYPA 27.326 172 122 3 69 237 5 176 6.84E-12 65.5 BRYP_PHYPA reviewed Bryoporin (PpBP) (Physcomitrin) PHYPADRAFT_61094 Physcomitrella patens subsp. patens (Moss) 178 cation transport [GO:0006812]; hemolysis in other organism involved in symbiotic interaction [GO:0052331]; pore complex assembly [GO:0046931] GO:0006812; GO:0015267; GO:0046930; GO:0046931; GO:0052331 0 0 0 PF06369; Q7Z5G4 CHOYP_LOC656123.1.1 m.23105 sp GOGA7_HUMAN 56.25 128 53 1 34 158 10 137 6.84E-51 162 GOGA7_HUMAN reviewed Golgin subfamily A member 7 (Golgi complex-associated protein of 16 kDa) GOLGA7 GCP16 HDCKB03P HSPC041 Homo sapiens (Human) 137 Golgi to plasma membrane protein transport [GO:0043001]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein stabilization [GO:0050821]; protein targeting to membrane [GO:0006612] GO:0002178; GO:0005795; GO:0006612; GO:0018230; GO:0031228; GO:0043001; GO:0050821; GO:0070062 0 0 0 PF10256; Q8ITC3 CHOYP_RS19.11.12 m.65470 sp RS19_ARGIR 73.684 114 29 1 1 114 27 139 6.84E-59 181 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8R512 CHOYP_LOC100185765.2.2 m.26728 sp UBX11_RAT 34.59 451 242 9 114 562 68 467 6.84E-81 265 UBX11_RAT reviewed UBX domain-containing protein 11 (Socius) (UBX domain-containing protein 5) Ubxn11 Soc Ubxd5 Rattus norvegicus (Rat) 485 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] GO:0005737; GO:0005856; GO:0043130; GO:0043161 0 0 0 PF08059;PF00789; Q96PZ2 CHOYP_BRAFLDRAFT_79380.3.3 m.58340 sp F111A_HUMAN 25.939 293 144 13 345 603 344 597 6.84E-06 53.1 F111A_HUMAN reviewed Protein FAM111A FAM111A KIAA1895 Homo sapiens (Human) 611 defense response to virus [GO:0051607]; DNA replication [GO:0006260]; negative regulation of viral genome replication [GO:0045071] GO:0000785; GO:0005634; GO:0005737; GO:0006260; GO:0045071; GO:0051607 0 0 0 0 Q9C0H5 CHOYP_RHG39.1.1 m.50810 sp RHG39_HUMAN 62.534 363 134 1 33 395 721 1081 6.84E-163 488 RHG39_HUMAN reviewed Rho GTPase-activating protein 39 ARHGAP39 KIAA1688 Homo sapiens (Human) 1083 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005634; GO:0005829; GO:0005856; GO:0007165; GO:0051056 0 0 0 PF00784;PF00620;PF00397; A7Y2W8 CHOYP_LOC100375514.5.6 m.49689 sp SC6A9_XENLA 54.115 401 168 2 37 437 12 396 6.85E-156 458 SC6A9_XENLA reviewed Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (xGlyT1) (Solute carrier family 6 member 9) slc6a9 glyt1 Xenopus laevis (African clawed frog) 633 amino acid transport [GO:0006865] GO:0005283; GO:0005328; GO:0005887; GO:0006865 0 0 0 PF00209; O88799 CHOYP_LOC100702037.1.1 m.57440 sp ZAN_MOUSE 30.733 423 261 15 285 699 1658 2056 6.85E-42 172 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; P79943 CHOYP_LOC100711118.1.1 m.14923 sp SLBP1_XENLA 65.823 79 26 1 134 211 125 203 6.85E-31 119 SLBP1_XENLA reviewed Histone RNA hairpin-binding protein (Histone stem-loop-binding protein 1) slbp1 hbp slbp Xenopus laevis (African clawed frog) 254 mRNA processing [GO:0006397] GO:0003729; GO:0005634; GO:0005737; GO:0006397 0 0 0 PF15247; Q0KHY3 CHOYP_LOC574757.1.9 m.13906 sp MESH_DROME 26.616 1052 599 41 23 966 181 1167 6.85E-71 262 MESH_DROME reviewed Protein mesh mesh CG31004 Drosophila melanogaster (Fruit fly) 1454 cell-matrix adhesion [GO:0007160]; multicellular organism development [GO:0007275]; smooth septate junction assembly [GO:0090528] GO:0005920; GO:0007160; GO:0007275; GO:0016021; GO:0016327; GO:0090528 0 0 0 PF03782;PF06119;PF00084;PF00094; Q5R662 CHOYP_LOC100373648.2.2 m.43770 sp LRP12_PONAB 26.316 152 83 4 53 197 68 197 6.85E-06 51.6 LRP12_PONAB reviewed Low-density lipoprotein receptor-related protein 12 (LRP-12) LRP12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 859 endocytosis [GO:0006897] GO:0005887; GO:0005905; GO:0006897 0 0 0 PF00431;PF00057; Q5XJS5 CHOYP_LOC100373136.1.1 m.6977 sp THOC6_DANRE 45.092 326 172 5 11 336 5 323 6.85E-100 300 THOC6_DANRE reviewed THO complex subunit 6 homolog (WD repeat-containing protein 58) thoc6 wdr58 zgc:101618 Danio rerio (Zebrafish) (Brachydanio rerio) 323 apoptotic process [GO:0006915]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism development [GO:0007275]; RNA splicing [GO:0008380] GO:0003723; GO:0006397; GO:0006915; GO:0007275; GO:0008380; GO:0016607; GO:0051028 0 0 0 PF00400; Q60431 CHOYP_BRAFLDRAFT_120993.2.2 m.47722 sp CASP3_MESAU 33.766 154 79 4 45 198 34 164 6.85E-16 80.9 CASP3_MESAU reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q8CE72 CHOYP_BRAFLDRAFT_117629.2.2 m.31330 sp CE042_MOUSE 28.309 1360 822 38 2 1284 90 1373 6.85E-131 461 CE042_MOUSE reviewed Uncharacterized protein C5orf42 homolog 0 Mus musculus (Mouse) 3214 cardiac septum development [GO:0003279]; cerebellum development [GO:0021549]; cilium assembly [GO:0042384]; coronary vasculature development [GO:0060976]; embryonic digit morphogenesis [GO:0042733]; establishment of planar polarity [GO:0001736]; heart development [GO:0007507]; kidney development [GO:0001822]; palate development [GO:0060021]; protein localization to ciliary transition zone [GO:1904491]; ventricular septum development [GO:0003281] GO:0001736; GO:0001822; GO:0003279; GO:0003281; GO:0007507; GO:0016021; GO:0021549; GO:0035869; GO:0042384; GO:0042733; GO:0060021; GO:0060976; GO:1904491 0 0 0 PF15392; Q96JI7 CHOYP_BRAFLDRAFT_78622.1.3 m.2676 sp SPTCS_HUMAN 28.442 661 390 16 20 665 1033 1625 6.85E-67 242 SPTCS_HUMAN reviewed Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) 2443 axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; synaptic vesicle transport [GO:0048489] GO:0005730; GO:0005737; GO:0005765; GO:0005829; GO:0005886; GO:0007268; GO:0008088; GO:0030424; GO:0030425; GO:0031410; GO:0045202; GO:0048489; GO:0048675; GO:0070062 0 0 0 PF14649; Q96PZ7 CHOYP_FHR1.1.1 m.31419 sp CSMD1_HUMAN 26.906 223 144 9 2 207 2996 3216 6.85E-13 72 CSMD1_HUMAN reviewed CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1) CSMD1 KIAA1890 UNQ5952/PRO19863 Homo sapiens (Human) 3565 0 GO:0016021 0 0 0 PF00431;PF00084; Q9NVA1 CHOYP_LOC655335.1.1 m.14025 sp UQCC1_HUMAN 32.292 192 124 2 96 282 88 278 6.85E-28 112 UQCC1_HUMAN reviewed Ubiquinol-cytochrome-c reductase complex assembly factor 1 (Basic FGF-repressed Zic-binding protein) (bFGF-repressed Zic-binding protein) (bFZb) (Ubiquinol-cytochrome c reductase complex chaperone CBP3 homolog) UQCC1 BZFB C20orf44 UQCC Homo sapiens (Human) 299 mitochondrial respiratory chain complex III assembly [GO:0034551]; positive regulation of mitochondrial translation [GO:0070131] GO:0005743; GO:0016023; GO:0034551; GO:0070131 0 0 0 PF03981; Q9P2E3 CHOYP_LOC100372654.1.2 m.25697 sp ZNFX1_HUMAN 38.043 368 199 10 64 418 1287 1638 6.85E-57 208 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9ULM3 CHOYP_YETS2.1.1 m.302 sp YETS2_HUMAN 49.394 330 128 8 4 296 5 332 6.85E-89 320 YETS2_HUMAN reviewed YEATS domain-containing protein 2 YEATS2 KIAA1197 Homo sapiens (Human) 1422 "histone H3 acetylation [GO:0043966]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]" GO:0000122; GO:0005671; GO:0017025; GO:0043966; GO:0045892; GO:0072686 0 0 0 PF03366; P18288 CHOYP_TBA1.5.9 m.23097 sp TBAT_ONCMY 93.074 231 16 0 5 235 37 267 6.86E-148 423 TBAT_ONCMY reviewed "Tubulin alpha chain, testis-specific [Cleaved into: Detyrosinated tubulin alpha chain, testis-specific]" 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q4WVW4 CHOYP_VAC8.1.1 m.9033 sp VAC8_ASPFU 42.529 522 272 12 35 547 12 514 6.86E-111 347 VAC8_ASPFU reviewed Vacuolar protein 8 vac8 AFUA_5G13540 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) 578 0 GO:0000329; GO:0005794 0 0 0 PF00514; Q5BL38 CHOYP_LOC100905760.1.1 m.22631 sp CEGT_XENTR 49.326 371 187 1 44 413 22 392 6.86E-129 380 CEGT_XENTR reviewed Ceramide glucosyltransferase (EC 2.4.1.80) (UDP-glucose ceramide glucosyltransferase) ugcg TEgg030g03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 394 glucosylceramide biosynthetic process [GO:0006679]; glycosphingolipid catabolic process [GO:0046479]; multicellular organism development [GO:0007275] GO:0000139; GO:0005794; GO:0006679; GO:0007275; GO:0008120; GO:0016020; GO:0016021; GO:0046479 PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:Q8AY29}. 0 0 PF13506; Q5T0B9 CHOYP_LOC660560.4.4 m.54542 sp ZN362_HUMAN 47.899 119 52 2 48 166 257 365 6.86E-33 127 ZN362_HUMAN reviewed Zinc finger protein 362 ZNF362 PP6997 Homo sapiens (Human) 420 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q5T0B9 CHOYP_RL3.7.7 m.57415 sp ZN362_HUMAN 47.899 119 52 2 48 166 257 365 6.86E-33 127 ZN362_HUMAN reviewed Zinc finger protein 362 ZNF362 PP6997 Homo sapiens (Human) 420 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q5TUE9 CHOYP_RM23.1.1 m.173 sp RM23_ANOGA 40.132 152 78 4 29 175 6 149 6.86E-25 97.1 RM23_ANOGA reviewed "Probable 39S ribosomal protein L23, mitochondrial (L23mt) (MRP-L23)" mRpL23 AGAP010338 Anopheles gambiae (African malaria mosquito) 151 mitochondrial translation [GO:0032543] GO:0000166; GO:0003723; GO:0003735; GO:0005762; GO:0032543 0 0 0 PF00276; Q5ZID0 CHOYP_LOC100368789.1.1 m.10141 sp NMRL1_CHICK 42.143 140 78 3 14 151 5 143 6.86E-28 108 NMRL1_CHICK reviewed NmrA-like family domain-containing protein 1 NMRAL1 RCJMB04_27o15 Gallus gallus (Chicken) 296 0 GO:0005634; GO:0048471 0 0 0 PF05368; Q61382 CHOYP_TRAF4.1.1 m.4304 sp TRAF4_MOUSE 49.26 473 229 6 1 465 1 470 6.86E-170 489 TRAF4_MOUSE reviewed TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1) Traf4 Cart1 Mus musculus (Mouse) 470 apoptotic process [GO:0006915]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of protein kinase activity [GO:0045860]; regulation of apoptotic process [GO:0042981]; respiratory gaseous exchange [GO:0007585]; respiratory tube development [GO:0030323]; signal transduction [GO:0007165] GO:0004842; GO:0005164; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0005923; GO:0006915; GO:0007165; GO:0007585; GO:0008270; GO:0019901; GO:0030323; GO:0031625; GO:0031996; GO:0042981; GO:0045860; GO:0046330; GO:0048471; GO:0050699; GO:0090073 0 0 0 PF00097;PF02176; Q8AWW4 CHOYP_GOLI.1.1 m.63255 sp RN128_XENLA 33.333 84 48 2 6 81 258 341 6.86E-09 61.6 RN128_XENLA reviewed E3 ubiquitin-protein ligase RNF128 (EC 6.3.2.-) (Goliath-related E3 ubiquitin-protein ligase 1) (RING finger protein 128) rnf128 greul1 Xenopus laevis (African clawed frog) 404 protein ubiquitination [GO:0016567] GO:0008270; GO:0012505; GO:0016021; GO:0016567; GO:0016874; GO:0048471 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02225;PF13639; Q8QZZ7 CHOYP_LOC100227090.1.1 m.1313 sp TPRKB_MOUSE 37.349 166 103 1 11 175 10 175 6.86E-44 146 TPRKB_MOUSE reviewed EKC/KEOPS complex subunit Tprkb (TP53RK-binding protein) Tprkb Mus musculus (Mouse) 175 tRNA processing [GO:0008033] GO:0005634; GO:0005737; GO:0005829; GO:0008033; GO:0019901 0 0 0 PF08617; Q8WXS8 CHOYP_ATS7.1.1 m.57352 sp ATS14_HUMAN 26.608 684 398 27 72 704 114 744 6.86E-42 171 ATS14_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-) ADAMTS14 Homo sapiens (Human) 1223 collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199] GO:0004222; GO:0005576; GO:0005578; GO:0008270; GO:0030199; GO:0030574 0 0 0 PF05986;PF01562;PF01421;PF00090; Q99K24 CHOYP_LOC576732.1.1 m.32206 sp S39A3_MOUSE 27.187 320 190 6 9 328 3 279 6.86E-24 102 S39A3_MOUSE reviewed Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3) Slc39a3 Zip3 Mus musculus (Mouse) 317 cell morphogenesis [GO:0000902]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; T cell homeostasis [GO:0043029]; zinc II ion transport [GO:0006829] GO:0000902; GO:0001701; GO:0005385; GO:0005886; GO:0006829; GO:0016021; GO:0043029; GO:0048701; GO:0060173 0 0 0 PF02535; Q9C8U0 CHOYP_BRAFLDRAFT_278918.5.5 m.48881 sp GSXL5_ARATH 32.187 407 247 10 5 393 8 403 6.86E-56 194 GSXL5_ARATH reviewed Flavin-containing monooxygenase FMO GS-OX-like 5 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 5) At1g63370 F2K11.25 F9N12.1 Arabidopsis thaliana (Mouse-ear cress) 450 oxidation-reduction process [GO:0055114] GO:0004497; GO:0004499; GO:0050660; GO:0050661; GO:0055114 0 0 0 PF00743; Q9WUL6 CHOYP_MAP3K14.1.1 m.62587 sp M3K14_MOUSE 27.228 202 130 8 164 362 394 581 6.86E-08 58.9 M3K14_MOUSE reviewed Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (Serine/threonine-protein kinase NIK) Map3k14 Nik Mus musculus (Mouse) 942 cellular response to mechanical stimulus [GO:0071260]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; immune response [GO:0006955]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004672; GO:0004674; GO:0004704; GO:0004709; GO:0005524; GO:0005737; GO:0006955; GO:0007249; GO:0043123; GO:0071260 0 0 0 PF00069; A8TX70 CHOYP_CO6A5.1.6 m.5838 sp CO6A5_HUMAN 28.979 911 531 27 67 964 235 1042 6.87E-93 341 CO6A5_HUMAN reviewed Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) (von Willebrand factor A domain-containing protein 4) COL6A5 COL29A1 VWA4 Homo sapiens (Human) 2615 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; P02259 CHOYP_contig_054986 m.65608 sp H5_CHICK 43.066 137 63 4 1 123 1 136 6.87E-23 93.6 H5_CHICK reviewed Histone H5 0 Gallus gallus (Chicken) 190 chromosome condensation [GO:0030261]; nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334; GO:0030261 0 0 0 PF00538; P06144 CHOYP_LOC100635715.8.9 m.63910 sp H1_LYTPI 64.865 74 26 0 29 102 18 91 6.87E-23 91.7 H1_LYTPI reviewed Late histone H1 0 Lytechinus pictus (Painted sea urchin) 210 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; P16157 CHOYP_LOC578679.3.6 m.22729 sp ANK1_HUMAN 34.328 268 157 3 184 451 267 515 6.87E-36 144 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P62972 CHOYP_UBIQP.9.13 m.26175 sp UBIQP_XENLA 92.174 115 1 1 1 115 61 167 6.87E-68 206 UBIQP_XENLA reviewed Polyubiquitin [Cleaved into: Ubiquitin] (Fragment) 0 Xenopus laevis (African clawed frog) 167 0 GO:0005634; GO:0005737 0 0 0 PF00240; Q01484 CHOYP_LOC100369901.2.2 m.21051 sp ANK2_HUMAN 31.535 241 112 4 9 212 101 325 6.87E-28 114 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q05609 CHOYP_CTR1.1.4 m.28426 sp CTR1_ARATH 36.246 309 175 10 340 643 514 805 6.87E-41 163 CTR1_ARATH reviewed Serine/threonine-protein kinase CTR1 (EC 2.7.11.1) (Protein CONSTITUTIVE TRIPLE RESPONSE1) CTR1 At5g03730 F17C15_150 Arabidopsis thaliana (Mouse-ear cress) 821 cellular response to iron ion [GO:0071281]; ethylene-activated signaling pathway [GO:0009873]; gibberellin biosynthetic process [GO:0009686]; negative regulation of ethylene-activated signaling pathway [GO:0010105]; protein autophosphorylation [GO:0046777]; regulation of post-embryonic root development [GO:2000069]; regulation of stem cell division [GO:2000035]; regulation of timing of transition from vegetative to reproductive phase [GO:0048510]; response to ethylene [GO:0009723]; response to fructose [GO:0009750]; response to hypoxia [GO:0001666]; response to sucrose [GO:0009744]; sugar mediated signaling pathway [GO:0010182] GO:0001666; GO:0004674; GO:0004712; GO:0005524; GO:0005789; GO:0009686; GO:0009723; GO:0009744; GO:0009750; GO:0009873; GO:0010105; GO:0010182; GO:0046777; GO:0048510; GO:0071281; GO:2000035; GO:2000069 0 0 0 PF07714; Q0ZM14 CHOYP_BRAFLDRAFT_62225.1.1 m.55569 sp PCD15_CHICK 36.697 109 62 3 6 112 781 884 6.87E-10 59.7 PCD15_CHICK reviewed Protocadherin-15 Pcdh15 Gallus gallus (Chicken) 1899 actin filament bundle assembly [GO:0051017]; adult walking behavior [GO:0007628]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in equilibrioception [GO:0050973]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of an epithelium [GO:0002009]; multicellular organism growth [GO:0035264]; nonmotile primary cilium assembly [GO:0035058]; righting reflex [GO:0060013]; startle response [GO:0001964]; visual perception [GO:0007601] GO:0001750; GO:0001964; GO:0002009; GO:0005509; GO:0005737; GO:0005886; GO:0007156; GO:0007601; GO:0007628; GO:0016021; GO:0032420; GO:0035058; GO:0035264; GO:0050910; GO:0050973; GO:0051017; GO:0060013; GO:0060088 0 0 0 PF00028; Q28IU1 CHOYP_LOC100371713.1.1 m.997 sp DHB12_XENTR 59.859 142 57 0 16 157 44 185 6.87E-53 174 DHB12_XENTR reviewed Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) hsd17b12 TNeu053h21.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 320 estrogen biosynthetic process [GO:0006703]; fatty acid biosynthetic process [GO:0006633]; steroid biosynthetic process [GO:0006694] GO:0004303; GO:0005789; GO:0006633; GO:0006694; GO:0006703; GO:0016021; GO:0102339; GO:0102340; GO:0102341 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q53GQ0}.; PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000250|UniProtKB:Q53GQ0}. 0 0 PF00106; Q54G05 CHOYP_TVAG_193760.1.4 m.10065 sp LRRX1_DICDI 28.365 624 340 25 625 1210 468 1022 6.87E-07 60.1 LRRX1_DICDI reviewed Putative leucine-rich repeat-containing protein DDB_G0290503 DDB_G0290503 Dictyostelium discoideum (Slime mold) 1492 reciprocal meiotic recombination [GO:0007131] GO:0000795; GO:0007131 0 0 0 PF00169; Q5R9W6 CHOYP_TAF13.1.3 m.20331 sp TAF13_PONAB 75.258 97 24 0 33 129 27 123 6.87E-51 160 TAF13_PONAB reviewed Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18) TAF13 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 124 "regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0005634; GO:0006355; GO:0006366 0 0 cd07978; PF02269; Q5ZMU0 CHOYP_RT07.1.1 m.48990 sp RT07_CHICK 42.169 166 94 2 79 243 68 232 6.87E-43 148 RT07_CHICK reviewed "28S ribosomal protein S7, mitochondrial (MRP-S7) (S7mt)" MRPS7 RCJMB04_1c20 Gallus gallus (Chicken) 233 mitochondrial translation [GO:0032543]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003729; GO:0003735; GO:0005763; GO:0006412; GO:0019843; GO:0032543 0 0 0 PF00177; Q6DIB5 CHOYP_BRAFLDRAFT_224574.1.18 m.1168 sp MEG10_MOUSE 36.12 299 168 14 13 305 160 441 6.87E-39 150 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6P2W7 CHOYP_LOC100371761.1.1 m.57462 sp LTOR1_XENTR 38.69 168 92 5 19 181 1 162 6.87E-26 100 LTOR1_XENTR reviewed Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) lamtor1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 162 cell growth [GO:0016049]; cellular protein localization [GO:0034613]; cellular response to amino acid stimulus [GO:0071230]; cholesterol homeostasis [GO:0042632]; endosome localization [GO:0032439]; endosome organization [GO:0007032]; lysosome localization [GO:0032418]; lysosome organization [GO:0007040]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of TOR signaling [GO:0032008]; regulation of cholesterol efflux [GO:0010874]; regulation of cholesterol esterification [GO:0010872]; regulation of cholesterol import [GO:0060620]; regulation of receptor recycling [GO:0001919] GO:0001919; GO:0005764; GO:0005765; GO:0005886; GO:0007032; GO:0007040; GO:0010872; GO:0010874; GO:0016049; GO:0031902; GO:0032008; GO:0032418; GO:0032439; GO:0034613; GO:0042632; GO:0043410; GO:0043547; GO:0045121; GO:0060620; GO:0071230; GO:0071986 0 0 0 PF15454; Q8K2R5 CHOYP_BRAFLDRAFT_100651.1.1 m.1013 sp ZN668_MOUSE 26.055 403 229 16 164 522 18 395 6.87E-23 106 ZN668_MOUSE reviewed Zinc finger protein 668 Znf668 Zfp668 Mus musculus (Mouse) 619 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 0 PF00096;PF13912; Q8N9V6 CHOYP_LOC100377534.1.1 m.7306 sp ANR53_HUMAN 28.798 441 262 11 34 467 111 506 6.87E-45 169 ANR53_HUMAN reviewed Ankyrin repeat domain-containing protein 53 ANKRD53 Homo sapiens (Human) 530 cell division [GO:0051301]; mitotic metaphase plate congression [GO:0007080]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236] GO:0000922; GO:0005737; GO:0005819; GO:0007080; GO:0031116; GO:0051301; GO:0060236; GO:1902412 0 0 0 PF12796; Q9UHG0 CHOYP_DCDC2.7.7 m.46807 sp DCDC2_HUMAN 31.662 379 217 14 2 365 6 357 6.87E-35 137 DCDC2_HUMAN reviewed Doublecortin domain-containing protein 2 (Protein RU2S) DCDC2 KIAA1154 RU2 Homo sapiens (Human) 476 cell projection organization [GO:0030030]; cellular defense response [GO:0006968]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0006968; GO:0007605; GO:0030030; GO:0030111; GO:0035556; GO:0045880; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; O00268 CHOYP_SI_DKEY-219C3.2.1.1 m.25159 sp TAF4_HUMAN 56.371 259 110 2 658 913 827 1085 6.88E-85 298 TAF4_HUMAN reviewed Transcription initiation factor TFIID subunit 4 (RNA polymerase II TBP-associated factor subunit C) (TBP-associated factor 4) (Transcription initiation factor TFIID 130 kDa subunit) (TAF(II)130) (TAFII-130) (TAFII130) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) TAF4 TAF2C TAF2C1 TAF4A TAFII130 TAFII135 Homo sapiens (Human) 1085 "DNA-templated transcription, initiation [GO:0006352]; ovarian follicle development [GO:0001541]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]" GO:0001541; GO:0003677; GO:0003700; GO:0003713; GO:0005654; GO:0005669; GO:0005737; GO:0006352; GO:0006357; GO:0006366; GO:0006367; GO:0006368; GO:0016032; GO:0033276; GO:0045893; GO:0071339; GO:1901796 0 0 cd08045; PF05236;PF07531; O75382 CHOYP_BRAFLDRAFT_88222.5.6 m.53846 sp TRIM3_HUMAN 23.881 268 173 8 302 552 489 742 6.88E-10 65.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P30204 CHOYP_REJ6.4.4 m.52823 sp MSRE_MOUSE 37.963 108 60 4 354 455 352 458 6.88E-10 67.4 MSRE_MOUSE reviewed Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor type A) (SR-A) (CD antigen CD204) Msr1 Scvr Mus musculus (Mouse) 458 cellular response to organic cyclic compound [GO:0071407]; cholesterol transport [GO:0030301]; lipoprotein transport [GO:0042953]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005581; GO:0005829; GO:0005886; GO:0006898; GO:0010744; GO:0010886; GO:0016021; GO:0030169; GO:0030301; GO:0031410; GO:0034362; GO:0034381; GO:0042953; GO:0071407 0 0 0 PF01391;PF03523;PF00530; P86854 CHOYP_SI_CH211-154O6.6.1.1 m.28192 sp PLCL_MYTGA 33.065 124 71 4 67 189 37 149 6.88E-14 71.6 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q0IHI3 CHOYP_LOC100375913.1.1 m.9170 sp CATIP_XENLA 49.18 366 173 4 21 375 8 371 6.88E-125 368 CATIP_XENLA reviewed Ciliogenesis-associated TTC17-interacting protein catip Xenopus laevis (African clawed frog) 376 actin filament polymerization [GO:0030041]; cilium organization [GO:0044782] GO:0005634; GO:0005737; GO:0005886; GO:0015629; GO:0030041; GO:0044782 0 0 0 0 Q460N3 CHOYP_PARP14.19.22 m.59129 sp PAR15_HUMAN 23.596 712 399 26 65 755 89 676 6.88E-32 135 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q4R9E0 CHOYP_BRAFLDRAFT_63652.1.1 m.8021 sp TECT3_MACFA 30.448 335 167 16 392 718 308 584 6.88E-29 125 TECT3_MACFA reviewed Tectonic-3 TCTN3 TECT3 QtsA-10216 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 608 apoptotic process [GO:0006915]; cilium morphogenesis [GO:0060271]; smoothened signaling pathway [GO:0007224] GO:0006915; GO:0007224; GO:0016021; GO:0060271 0 0 0 PF07773; Q52KI8 CHOYP_SRRM1.3.3 m.57839 sp SRRM1_MOUSE 69.333 75 23 0 15 89 2 76 6.88E-28 108 SRRM1_MOUSE reviewed Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101) Srrm1 Pop101 Mus musculus (Mouse) 946 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0003677; GO:0005681; GO:0016363; GO:0016607 0 0 0 PF01480; Q7TPV2 CHOYP_NEMVEDRAFT_V1G233709.8.13 m.55781 sp DZIP3_MOUSE 31.461 89 59 1 67 153 453 541 6.88E-08 56.2 DZIP3_MOUSE reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) 1204 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q7Z7A1 CHOYP_LOC100175166.1.1 m.60935 sp CNTRL_HUMAN 28.653 1054 634 21 81 1090 1161 2140 6.88E-82 300 CNTRL_HUMAN reviewed Centriolin (Centrosomal protein 1) (Centrosomal protein of 110 kDa) (Cep110) CNTRL CEP1 CEP110 Homo sapiens (Human) 2325 cell division [GO:0051301]; G2/M transition of mitotic cell cycle [GO:0000086] GO:0000086; GO:0004713; GO:0005737; GO:0005813; GO:0005829; GO:0016020; GO:0051301 0 0 0 0 Q8NA66 CHOYP_LOC100378053.1.1 m.29624 sp CNBD1_HUMAN 26.747 415 259 11 36 428 37 428 6.88E-33 133 CNBD1_HUMAN reviewed Cyclic nucleotide-binding domain-containing protein 1 CNBD1 Homo sapiens (Human) 436 0 0 0 0 0 0 Q9SKB3 CHOYP_LOC100367685.1.1 m.8617 sp PARG1_ARATH 41.502 253 129 8 115 362 131 369 6.88E-43 169 PARG1_ARATH reviewed Poly(ADP-ribose) glycohydrolase 1 (EC 3.2.1.143) PARG1 TEJ At2g31870 At2g31875 F20M17.9 Arabidopsis thaliana (Mouse-ear cress) 548 carbohydrate metabolic process [GO:0005975]; cellular response to DNA damage stimulus [GO:0006974]; defense response to fungus [GO:0050832]; regulation of DNA repair [GO:0006282]; response to osmotic stress [GO:0006970]; response to oxidative stress [GO:0006979]; response to water deprivation [GO:0009414]; rhythmic process [GO:0048511]; stomatal closure [GO:0090332] GO:0004649; GO:0005975; GO:0006282; GO:0006970; GO:0006974; GO:0006979; GO:0009414; GO:0048511; GO:0050832; GO:0090332 0 0 0 PF05028; B0BN49 CHOYP_BM1_02690.1.1 m.5758 sp RBMX2_RAT 63.158 152 56 0 1 152 1 152 6.89E-68 220 RBMX2_RAT reviewed "RNA-binding motif protein, X-linked 2" Rbmx2 Rattus norvegicus (Rat) 328 "mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005686; GO:0006406; GO:0044822; GO:0070274; GO:0071011; GO:0071013 0 0 0 PF00076; E1BM58 CHOYP_RMDY18_11240.1.1 m.40286 sp PRAX_BOVIN 32.653 98 51 4 174 265 560 648 6.89E-11 67.8 PRAX_BOVIN reviewed Periaxin PRX Bos taurus (Bovine) 1349 0 GO:0005634; GO:0005737; GO:0005886; GO:0005912 0 0 0 0 G5E8K5 CHOYP_LOC756445.1.1 m.33707 sp ANK3_MOUSE 24.26 338 237 9 308 645 317 635 6.89E-17 89 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O00461 CHOYP_TVAG_168130.1.2 m.10205 sp GOLI4_HUMAN 26.289 194 117 2 3 170 4 197 6.89E-11 67 GOLI4_HUMAN reviewed "Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)" GOLIM4 GIMPC GOLPH4 GPP130 Homo sapiens (Human) 696 transport [GO:0006810] GO:0000139; GO:0005654; GO:0005794; GO:0005796; GO:0005801; GO:0006810; GO:0010008; GO:0016020; GO:0016021; GO:0030133; GO:0030139; GO:0032580 0 0 0 0 O14975 CHOYP_BRAFLDRAFT_68867.1.1 m.4095 sp S27A2_HUMAN 39.932 586 325 10 58 635 52 618 6.89E-139 421 S27A2_HUMAN reviewed "Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)" SLC27A2 ACSVL1 FACVL1 FATP2 VLACS Homo sapiens (Human) 620 bile acid biosynthetic process [GO:0006699]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; very long-chain fatty acid catabolic process [GO:0042760] GO:0001561; GO:0001676; GO:0004467; GO:0005102; GO:0005524; GO:0005739; GO:0005778; GO:0005779; GO:0005788; GO:0005789; GO:0006635; GO:0006699; GO:0015245; GO:0019899; GO:0030176; GO:0031957; GO:0042760; GO:0044539; GO:0050197; GO:0070062; GO:0070251; GO:0097089; GO:0102391 0 0 0 PF00501;PF13193; O75382 CHOYP_contig_031949 m.36437 sp TRIM3_HUMAN 23.596 267 186 6 180 441 489 742 6.89E-12 71.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P10394 CHOYP_LOC100708199.5.6 m.34124 sp POL4_DROME 29.388 997 598 16 318 1239 266 1231 6.89E-129 434 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P16157 CHOYP_LOC100197555.7.7 m.63676 sp ANK1_HUMAN 34.891 321 209 0 3 323 179 499 6.89E-53 190 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P84175 CHOYP_LOC100376688.4.8 m.31197 sp RS12_CHICK 81.89 127 23 0 16 142 6 132 6.89E-73 217 RS12_CHICK reviewed 40S ribosomal protein S12 RPS12 Gallus gallus (Chicken) 132 translation [GO:0006412] GO:0003735; GO:0006412; GO:0016020; GO:0022627; GO:0044822 0 0 0 PF01248; P98160 CHOYP_HMCN1.18.44 m.36924 sp PGBM_HUMAN 27.949 390 249 14 20 399 3030 3397 6.89E-23 108 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; Q05546 CHOYP_LOC100641827.1.2 m.31581 sp TENR_RAT 42.791 215 116 5 125 335 1131 1342 6.89E-52 187 TENR_RAT reviewed Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Rattus norvegicus (Rat) 1356 cell adhesion [GO:0007155]; negative regulation of cell adhesion [GO:0007162]; nervous system development [GO:0007399]; regulation of neurogenesis [GO:0050767] GO:0005178; GO:0005578; GO:0007155; GO:0007162; GO:0007399; GO:0050767 0 0 0 PF00147;PF00041; Q08DY9 CHOYP_LOC100931580.1.2 m.40622 sp CASP3_BOVIN 35.743 249 138 5 170 414 45 275 6.89E-44 157 CASP3_BOVIN reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Bos taurus (Bovine) 275 erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182] GO:0005737; GO:0030182; GO:0030216; GO:0030218; GO:0097194; GO:0097200 0 0 0 0 Q5RI75 CHOYP_LOC100377113.3.3 m.37327 sp RASEF_MOUSE 45.274 201 103 2 38 231 426 626 6.89E-55 188 RASEF_MOUSE reviewed Ras and EF-hand domain-containing protein homolog Rasef Mus musculus (Mouse) 627 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0007264; GO:0048471 0 0 0 PF00071; Q5XI70 CHOYP_PCGF6.1.1 m.66529 sp PCGF6_RAT 37.86 243 127 4 56 296 123 343 6.89E-40 145 PCGF6_RAT reviewed Polycomb group RING finger protein 6 (RING finger protein 134) Pcgf6 Rnf134 Rattus norvegicus (Rat) 351 "transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0001227; GO:0006351; GO:0008270; GO:0031519; GO:0035102 0 0 0 0 Q8IYB1 CHOYP_NEMVEDRAFT_V1G218264.7.14 m.32572 sp M21D2_HUMAN 26.506 166 102 5 176 334 233 385 6.89E-09 62.4 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q98SN7 CHOYP_LOC100533350.1.1 m.30143 sp WNT2B_CHICK 64.058 345 117 3 21 365 39 376 6.89E-167 474 WNT2B_CHICK reviewed Protein Wnt-2b WNT2B Gallus gallus (Chicken) 385 camera-type eye photoreceptor cell differentiation [GO:0060219]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell proliferation [GO:0008283]; cornea development in camera-type eye [GO:0061303]; embryonic camera-type eye formation [GO:0060900]; embryonic forelimb morphogenesis [GO:0035115]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; limb development [GO:0060173]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of glial cell differentiation [GO:0045686]; negative regulation of neuron differentiation [GO:0045665]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of fibroblast growth factor production [GO:0090270]; retina layer formation [GO:0010842]; Wnt signaling pathway [GO:0016055] GO:0002011; GO:0002088; GO:0003407; GO:0005109; GO:0005578; GO:0005615; GO:0008283; GO:0010842; GO:0016055; GO:0030182; GO:0035115; GO:0045165; GO:0045665; GO:0045686; GO:0045743; GO:0060070; GO:0060173; GO:0060219; GO:0060828; GO:0060900; GO:0061072; GO:0061303; GO:0090270; GO:0090271 0 0 0 PF00110; Q9QYV8 CHOYP_TRIADDRAFT_64268.1.1 m.18772 sp DPOG1_RAT 38 150 88 3 48 196 44 189 6.89E-25 104 DPOG1_RAT reviewed DNA polymerase subunit gamma-1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) Polg Mip1 Polg1 Rattus norvegicus (Rat) 1216 "aging [GO:0007568]; base-excision repair, gap-filling [GO:0006287]; cellular response to glucose stimulus [GO:0071333]; mitochondrial DNA replication [GO:0006264]; response to gamma radiation [GO:0010332]; response to hyperoxia [GO:0055093]; response to light stimulus [GO:0009416]" GO:0003677; GO:0003682; GO:0003887; GO:0005739; GO:0005760; GO:0006264; GO:0006287; GO:0007568; GO:0008408; GO:0009416; GO:0010332; GO:0042645; GO:0043195; GO:0055093; GO:0070062; GO:0071333 0 0 0 PF00476; Q9R1R2 CHOYP_BRAFLDRAFT_87306.2.4 m.20458 sp TRIM3_MOUSE 25.373 134 90 3 98 225 614 743 6.89E-08 56.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9Y493 CHOYP_NEMVEDRAFT_V1G247997.1.3 m.54636 sp ZAN_HUMAN 32.806 253 145 4 605 832 535 787 6.89E-17 90.5 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; A2V7M9 CHOYP_LOC663374.1.1 m.7353 sp PGAP3_CRIGR 45.638 298 160 2 32 328 20 316 6.90E-89 272 PGAP3_CRIGR reviewed Post-GPI attachment to proteins factor 3 (PER1-like domain-containing protein 1) PGAP3 PERLD1 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 320 GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505] GO:0000139; GO:0006505; GO:0006506; GO:0016021; GO:0016788; GO:0031227 0 0 0 PF04080; B1H349 CHOYP_SOX5.1.1 m.12268 sp SOX6_XENTR 69.291 127 35 1 408 530 548 674 6.90E-56 205 SOX6_XENTR reviewed Transcription factor Sox-6 (SRY (sex determining region Y)-box 6) sox6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 777 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275 0 0 0 PF00505; O19015 CHOYP_LOC100634556.1.1 m.45015 sp BGAL_FELCA 52.941 102 48 0 1 102 153 254 6.90E-33 122 BGAL_FELCA reviewed Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) GLB1 BGAL Felis catus (Cat) (Felis silvestris catus) 669 carbohydrate metabolic process [GO:0005975] GO:0004565; GO:0005764; GO:0005773; GO:0005975 0 0 0 PF13364;PF01301; O70277 CHOYP_LOC100373444.1.79 m.1083 sp TRIM3_RAT 24.074 216 150 6 15 218 484 697 6.90E-08 55.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P06857 CHOYP_LOC100487643.1.1 m.8220 sp LIPR1_CANLF 38.4 125 73 1 16 136 6 130 6.90E-23 95.9 LIPR1_CANLF reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Canis lupus familiaris (Dog) (Canis familiaris) 467 lipid catabolic process [GO:0016042] GO:0005509; GO:0005576; GO:0016042; GO:0052689 0 0 0 PF00151;PF01477; Q1LWH4 CHOYP_LOC578527.1.1 m.15981 sp FAN1_DANRE 43.243 333 181 4 16 341 592 923 6.90E-80 265 FAN1_DANRE reviewed Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (Myotubularin-related protein 15) fan1 mtmr15 si:ch211-163b1.2 si:ch211-201b11.2 Danio rerio (Zebrafish) (Brachydanio rerio) 988 "DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA incision [GO:0033683]" GO:0000724; GO:0004528; GO:0005634; GO:0006281; GO:0006289; GO:0008409; GO:0017108; GO:0033683; GO:0036297; GO:0043130; GO:0046872; GO:0070336 0 0 0 PF08774; Q92113 CHOYP_LOC100371043.4.5 m.34261 sp CP17A_SQUAC 41.322 242 138 3 6 245 260 499 6.90E-60 199 CP17A_SQUAC reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) 509 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q9ESN6 CHOYP_TRIM29.1.1 m.32438 sp TRIM2_MOUSE 28.249 177 97 8 76 239 536 695 6.90E-07 53.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5ED84 CHOYP_ZBTB5.4.4 m.42642 sp KLHL8_CAEEL 29.586 169 108 7 8 172 88 249 6.91E-09 63.2 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O05389 CHOYP_LOC552024.1.1 m.5290 sp YRBE_BACSU 30.746 335 223 4 43 377 8 333 6.91E-52 179 YRBE_BACSU reviewed Uncharacterized oxidoreductase YrbE (EC 1.-.-.-) yrbE BSU27770 Bacillus subtilis (strain 168) 341 oxidation-reduction process [GO:0055114] GO:0016491; GO:0055114 0 0 0 PF01408;PF02894; O43299 CHOYP_AP5Z1.1.1 m.37412 sp AP5Z1_HUMAN 39.151 212 120 5 10 215 586 794 6.91E-38 142 AP5Z1_HUMAN reviewed AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) AP5Z1 KIAA0415 SPG48 Homo sapiens (Human) 807 double-strand break repair via homologous recombination [GO:0000724]; endosomal transport [GO:0016197]; protein transport [GO:0015031] GO:0000724; GO:0005634; GO:0005654; GO:0005737; GO:0015031; GO:0016197; GO:0030119; GO:0044599 0 0 0 PF14764; P52740 CHOYP_ZN729.1.1 m.13702 sp ZN132_HUMAN 32.463 613 378 11 700 1296 113 705 6.91E-87 302 ZN132_HUMAN reviewed Zinc finger protein 132 ZNF132 Homo sapiens (Human) 706 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0046872 0 0 cd07765; PF01352;PF00096; P55266 CHOYP_DSRAD.2.4 m.5411 sp DSRAD_RAT 30 180 86 7 8 150 562 738 6.91E-09 57.4 DSRAD_RAT reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) Adar Dsrad Rattus norvegicus (Rat) 1175 "adenosine to inosine editing [GO:0006382]; defense response to virus [GO:0051607]; gene silencing by RNA [GO:0031047]; innate immune response [GO:0045087]; mRNA processing [GO:0006397]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; positive regulation of viral genome replication [GO:0045070]; regulation of transcription, DNA-templated [GO:0006355]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0003726; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0006382; GO:0006397; GO:0009615; GO:0016607; GO:0031047; GO:0035455; GO:0044387; GO:0044530; GO:0045070; GO:0045087; GO:0046872; GO:0051607 0 0 0 PF02137;PF00035;PF02295; P83425 CHOYP_BRAFLDRAFT_69134.4.13 m.20979 sp HIP_MYTED 29.464 112 74 1 13 119 56 167 6.91E-09 55.8 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q09575 CHOYP_LOC100372999.2.3 m.45127 sp YRD6_CAEEL 32.768 354 205 7 17 343 677 1024 6.91E-54 197 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q5RDY4 CHOYP_LOC100697330.1.1 m.2532 sp S27A4_PONAB 37.805 82 51 0 22 103 562 643 6.91E-13 66.2 S27A4_PONAB reviewed Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4) SLC27A4 FATP4 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 643 fatty acid transport [GO:0015908] GO:0000166; GO:0004467; GO:0005789; GO:0015908; GO:0016021; GO:0031957 0 0 0 PF00501;PF13193; Q6NWF4 CHOYP_VPS25.1.1 m.66093 sp VPS25_DANRE 64.162 173 61 1 20 192 3 174 6.91E-80 238 VPS25_DANRE reviewed Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) vps25 Danio rerio (Zebrafish) (Brachydanio rerio) 174 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328] GO:0000814; GO:0005198; GO:0042803; GO:0043328 0 0 0 PF05871; Q8BJM3 CHOYP_LOC100378849.1.1 m.21445 sp R3HCL_MOUSE 57.576 198 77 3 442 634 574 769 6.91E-59 214 R3HCL_MOUSE reviewed Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88 homolog) (R3H and coiled-coil domain-containing protein 1-like) R3hcc1l D19Ertd386e Gidrp88 Mus musculus (Mouse) 775 0 GO:0000166; GO:0035145 0 0 0 0 Q8T4F7 CHOYP_ENA.2.2 m.66560 sp ENA_DROME 64.8 125 42 1 24 146 294 418 6.91E-50 177 ENA_DROME reviewed Protein enabled ena enb CG15112 Drosophila melanogaster (Fruit fly) 980 "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; border follicle cell migration [GO:0007298]; compound eye development [GO:0048749]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dorsal closure [GO:0007391]; epithelial cell morphogenesis [GO:0003382]; formation of a compartment boundary [GO:0060288]; germ-band shortening [GO:0007390]; gonad morphogenesis [GO:0035262]; head involution [GO:0008258]; negative regulation of synaptic growth at neuromuscular junction [GO:0045886]; positive regulation of cell migration [GO:0030335]; positive regulation of cell projection organization [GO:0031346]; positive regulation of filopodium assembly [GO:0051491]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of cell shape [GO:0008360]; regulation of filopodium assembly [GO:0051489]; regulation of lamellipodium assembly [GO:0010591]; subsynaptic reticulum organization [GO:1990255]; suture of dorsal opening [GO:0007396]" GO:0003382; GO:0003779; GO:0005829; GO:0005856; GO:0005911; GO:0005912; GO:0007010; GO:0007015; GO:0007298; GO:0007303; GO:0007390; GO:0007391; GO:0007396; GO:0007409; GO:0007411; GO:0008064; GO:0008258; GO:0008360; GO:0010591; GO:0017124; GO:0030027; GO:0030036; GO:0030335; GO:0030424; GO:0030425; GO:0031252; GO:0031346; GO:0032433; GO:0032956; GO:0035262; GO:0045886; GO:0048749; GO:0048813; GO:0051489; GO:0051491; GO:0060288; GO:0071212; GO:1990255 0 0 0 PF08776;PF00568; Q95LG1 CHOYP_LYAM2.1.1 m.39809 sp LYAM2_HORSE 27.049 488 278 25 26 478 164 608 6.91E-26 114 LYAM2_HORSE reviewed E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE Equus caballus (Horse) 610 cell adhesion [GO:0007155] GO:0005509; GO:0005886; GO:0007155; GO:0016021; GO:0030246 0 0 0 PF00008;PF00059;PF00084; Q9UGM3 CHOYP_BRAFLDRAFT_68915.3.7 m.4916 sp DMBT1_HUMAN 33.223 605 339 15 191 746 113 701 6.91E-73 271 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UPV0 CHOYP_CEP164.1.1 m.40330 sp CE164_HUMAN 67.677 99 32 0 9 107 8 106 6.91E-41 169 CE164_HUMAN reviewed Centrosomal protein of 164 kDa (Cep164) CEP164 KIAA1052 NPHP15 Homo sapiens (Human) 1460 cell division [GO:0051301]; cilium assembly [GO:0042384]; DNA repair [GO:0006281]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067] GO:0000086; GO:0005615; GO:0005654; GO:0005813; GO:0005814; GO:0005829; GO:0006281; GO:0007067; GO:0042384; GO:0051301; GO:0097539 0 0 0 0 Q9UPV9 CHOYP_TRAK1.1.2 m.56123 sp TRAK1_HUMAN 38.921 686 311 21 1 619 105 749 6.91E-110 361 TRAK1_HUMAN reviewed Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) TRAK1 KIAA1042 OIP106 Homo sapiens (Human) 953 endosome to lysosome transport [GO:0008333]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0005634; GO:0005737; GO:0005739; GO:0005769; GO:0006357; GO:0006493; GO:0006605; GO:0008333 0 0 0 PF04849;PF12448; Q9VGH7 CHOYP_BRAFLDRAFT_118473.2.3 m.19003 sp CLCN2_DROME 58.289 374 154 2 1 373 288 660 6.91E-141 432 CLCN2_DROME reviewed Chloride channel protein 2 (ClC-2) (DmClC-2) (Chloride channel-a) ClC-a CG31116 Drosophila melanogaster (Fruit fly) 1193 chloride transport [GO:0006821] GO:0005247; GO:0006821; GO:0015629; GO:0034707 0 0 0 PF00654; B5X3I6 CHOYP_AAEL_AAEL014311.1.2 m.9827 sp TSN9_SALSA 23.469 196 129 4 70 265 58 232 6.92E-10 61.2 TSN9_SALSA reviewed Tetraspanin-9 (Tspan-9) tspan9 Salmo salar (Atlantic salmon) 239 0 GO:0016021 0 0 0 PF00335; O45782 CHOYP_AGAP_AGAP001894.1.1 m.27265 sp ARD17_CAEEL 27.273 319 198 11 13 316 7 306 6.92E-22 100 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; P21329 CHOYP_LOC100890271.1.2 m.22049 sp RTJK_DROFU 23.26 546 383 16 228 751 65 596 6.92E-17 89 RTJK_DROFU reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) jockey\pol pol Drosophila funebris (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; Q1L8X9 CHOYP_LOC410752.1.1 m.48382 sp VGLU3_DANRE 34.444 180 103 5 2 177 71 239 6.92E-24 100 VGLU3_DANRE reviewed Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) slc17a8 vglut3 si:ch211-264e16.4 Danio rerio (Zebrafish) (Brachydanio rerio) 590 equilibrioception [GO:0050957]; neurotransmitter transport [GO:0006836]; regulation of synapse structure or activity [GO:0050803]; sodium ion transport [GO:0006814]; vestibular reflex [GO:0060005] GO:0005313; GO:0006814; GO:0006836; GO:0015293; GO:0016021; GO:0030054; GO:0030672; GO:0043005; GO:0050803; GO:0050957; GO:0060005 0 0 cd06174; PF07690; Q32M45 CHOYP_LOC100369417.2.2 m.61030 sp ANO4_HUMAN 28.942 501 236 14 75 542 118 531 6.92E-42 164 ANO4_HUMAN reviewed Anoctamin-4 (Transmembrane protein 16D) ANO4 TMEM16D Homo sapiens (Human) 955 calcium activated galactosylceramide scrambling [GO:0061591]; calcium activated phosphatidylcholine scrambling [GO:0061590]; calcium activated phosphatidylserine scrambling [GO:0061589]; chloride transport [GO:0006821]; ion transmembrane transport [GO:0034220] GO:0005229; GO:0005622; GO:0005886; GO:0006821; GO:0016021; GO:0017128; GO:0034220; GO:0061589; GO:0061590; GO:0061591 0 0 0 PF16178;PF04547; Q66IB8 CHOYP_CB076.1.1 m.27190 sp CB076_DANRE 56.452 124 51 1 18 141 6 126 6.92E-47 150 CB076_DANRE reviewed UPF0538 protein C2orf76 homolog zgc:101851 Danio rerio (Zebrafish) (Brachydanio rerio) 126 0 0 0 0 0 PF10209; Q6P8U6 CHOYP_PNLIPRP3.3.3 m.57288 sp LIPP_MOUSE 37.113 291 153 7 405 668 42 329 6.92E-47 175 LIPP_MOUSE reviewed Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) Pnlip Mus musculus (Mouse) 465 intestinal cholesterol absorption [GO:0030299]; lipid catabolic process [GO:0016042]; positive regulation of triglyceride lipase activity [GO:0061365] GO:0004806; GO:0005576; GO:0016042; GO:0030299; GO:0046872; GO:0061365 0 0 0 PF00151;PF01477; Q76I76 CHOYP_LOC100651687.1.1 m.39884 sp SSH2_HUMAN 51.142 438 204 5 72 501 32 467 6.92E-134 450 SSH2_HUMAN reviewed Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L) SSH2 KIAA1725 SSH2L Homo sapiens (Human) 1423 actin cytoskeleton organization [GO:0030036]; protein dephosphorylation [GO:0006470]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of lamellipodium assembly [GO:0010591] GO:0003677; GO:0003779; GO:0004721; GO:0004725; GO:0005615; GO:0005737; GO:0005856; GO:0006470; GO:0008064; GO:0008138; GO:0010591; GO:0030036; GO:0050770 0 0 0 PF08766;PF00782; Q7LHG5 CHOYP_CRE_22890.1.1 m.10656 sp YI31B_YEAST 31.707 779 475 14 259 1029 614 1343 6.92E-103 362 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q8WWK9 CHOYP_TOLL.1.2 m.24345 sp CKAP2_HUMAN 26.667 255 120 9 383 576 421 669 6.92E-12 72 CKAP2_HUMAN reviewed Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) CKAP2 LB1 TMAP Homo sapiens (Human) 683 apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000281; GO:0000922; GO:0005737; GO:0005813; GO:0005881; GO:0006915; GO:0007026; GO:0015630; GO:0045944 0 0 0 PF15297; Q9R1R2 CHOYP_BRAFLDRAFT_79377.10.30 m.32783 sp TRIM3_MOUSE 27.53 247 166 7 312 549 489 731 6.92E-14 78.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9WVF8 CHOYP_LOC100668913.1.1 m.6819 sp TUSC2_MOUSE 50.649 77 34 1 32 104 34 110 6.92E-21 83.2 TUSC2_MOUSE reviewed Tumor suppressor candidate 2 (Fusion 1 protein) (Fus-1 protein) (PDGFA-associated protein 2) Tusc2 Fus1 Lgcc Pdap2 Mus musculus (Mouse) 110 cell maturation [GO:0048469]; chemokine (C-C motif) ligand 5 production [GO:0071609]; defense response to Gram-negative bacterium [GO:0050829]; inflammatory response [GO:0006954]; interleukin-15 production [GO:0032618]; natural killer cell differentiation [GO:0001779]; negative regulation of interleukin-17 production [GO:0032700]; neutrophil mediated killing of gram-negative bacterium [GO:0070945]; phagocytosis [GO:0006909]; positive regulation of interleukin-10 production [GO:0032733]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of reactive oxygen species metabolic process [GO:2000377]; response to defense-related host reactive oxygen species production [GO:0052567] GO:0001779; GO:0005739; GO:0006909; GO:0006954; GO:0032618; GO:0032700; GO:0032733; GO:0048469; GO:0050829; GO:0051881; GO:0052567; GO:0070945; GO:0071609; GO:2000377 0 0 0 PF15000; H2A0M0 CHOYP_NRP.1.4 m.29956 sp NRP_PINMG 26.022 269 169 13 85 339 429 681 6.93E-18 88.2 NRP_PINMG reviewed Asparagine-rich protein (Prism uncharacterized shell protein 1) (PUSP1) 0 Pinctada margaritifera (Black-lipped pearl oyster) 686 0 GO:0005576 0 0 0 0 O00628 CHOYP_LOC100370808.1.1 m.42194 sp PEX7_HUMAN 56.23 313 135 2 19 330 12 323 6.93E-135 389 PEX7_HUMAN reviewed Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7) PEX7 PTS2R Homo sapiens (Human) 323 endochondral ossification [GO:0001958]; ether lipid biosynthetic process [GO:0008611]; fatty acid beta-oxidation [GO:0006635]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558] GO:0001764; GO:0001958; GO:0005053; GO:0005777; GO:0005782; GO:0005829; GO:0006635; GO:0007031; GO:0008611; GO:0016558; GO:0019899; GO:0042803 0 0 0 PF00400; P04323 CHOYP_LOC100535305.1.2 m.35477 sp POL3_DROME 40.24 333 189 4 51 374 148 479 6.93E-80 268 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P10079 CHOYP_LOC100633983.2.2 m.62010 sp FBP1_STRPU 55.041 367 165 0 2 368 185 551 6.93E-124 385 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; Q0VCQ7 CHOYP_LOC100700623.1.1 m.47168 sp ICE2_BOVIN 24.566 403 232 14 4 394 11 353 6.93E-20 96.7 ICE2_BOVIN reviewed Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) ICE2 NARG2 Bos taurus (Bovine) 981 positive regulation of transcription from RNA polymerase III promoter [GO:0045945]; snRNA transcription from RNA polymerase III promoter [GO:0042796]; snRNA transcription from RNA polymerase II promoter [GO:0042795] GO:0008023; GO:0015030; GO:0035327; GO:0035363; GO:0042795; GO:0042796; GO:0045945 0 0 0 PF10505; Q3Y4E2 CHOYP_LOC100709538.2.2 m.28816 sp SELN_DANRE 39.024 164 89 5 60 215 118 278 6.93E-24 102 SELN_DANRE reviewed Selenoprotein N (SePN) (SelN) sepn1 sepn Danio rerio (Zebrafish) (Brachydanio rerio) 557 calcium-mediated signaling [GO:0019722]; muscle fiber development [GO:0048747]; muscle tissue development [GO:0060537]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; skeletal muscle fiber development [GO:0048741] GO:0005789; GO:0016021; GO:0016491; GO:0019722; GO:0048741; GO:0048747; GO:0060314; GO:0060537 0 0 0 0 Q4PM12 CHOYP_BRAFLDRAFT_204871.1.1 m.66069 sp RL36_IXOSC 60.784 102 38 1 7 108 1 100 6.93E-39 129 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q6NSJ0 CHOYP_LOC576508.1.1 m.46146 sp K1161_HUMAN 37.398 246 149 4 116 357 158 402 6.93E-52 186 K1161_HUMAN reviewed Uncharacterized family 31 glucosidase KIAA1161 (EC 3.2.1.-) KIAA1161 Homo sapiens (Human) 714 carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of protein kinase B signaling [GO:0051897]; skeletal muscle fiber development [GO:0048741] GO:0004553; GO:0005975; GO:0016021; GO:0031965; GO:0043568; GO:0048741; GO:0051897 0 0 0 PF01055; Q8IYT2 CHOYP_FTSJD1.1.1 m.59388 sp CMTR2_HUMAN 33.995 756 423 19 24 727 26 757 6.93E-124 390 CMTR2_HUMAN reviewed Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog) CMTR2 AFT FTSJD1 Homo sapiens (Human) 770 7-methylguanosine mRNA capping [GO:0006370]; cap2 mRNA methylation [GO:0097310] GO:0004483; GO:0005634; GO:0005737; GO:0006370; GO:0016021; GO:0097310 0 0 0 PF01728; Q96JI7 CHOYP_SPG11.1.1 m.4403 sp SPTCS_HUMAN 28.519 810 521 16 16 796 1635 2415 6.93E-86 303 SPTCS_HUMAN reviewed Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) SPG11 KIAA1840 Homo sapiens (Human) 2443 axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; synaptic vesicle transport [GO:0048489] GO:0005730; GO:0005737; GO:0005765; GO:0005829; GO:0005886; GO:0007268; GO:0008088; GO:0030424; GO:0030425; GO:0031410; GO:0045202; GO:0048489; GO:0048675; GO:0070062 0 0 0 PF14649; Q9BXJ5 CHOYP_BRAFLDRAFT_69134.9.13 m.56883 sp C1QT2_HUMAN 32.174 115 71 4 78 190 151 260 6.93E-09 57.8 C1QT2_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 2 C1QTNF2 CTRP2 UNQ6349/PRO21054 Homo sapiens (Human) 285 activation of MAPK activity [GO:0000187]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein heterotrimerization [GO:0070208]; protein homooligomerization [GO:0051260] GO:0000187; GO:0005581; GO:0005615; GO:0045725; GO:0046321; GO:0046326; GO:0051260; GO:0070208 0 0 0 PF00386;PF01391; Q9NNW5 CHOYP_DEHA2A06358G.1.1 m.64514 sp WDR6_HUMAN 29.371 143 83 4 135 263 976 1114 6.93E-12 68.9 WDR6_HUMAN reviewed WD repeat-containing protein 6 WDR6 Homo sapiens (Human) 1121 cell cycle arrest [GO:0007050]; negative regulation of autophagy [GO:0010507]; negative regulation of cell proliferation [GO:0008285] GO:0005737; GO:0007050; GO:0008285; GO:0010507; GO:0044822 0 0 0 PF00400; Q9NRM2 CHOYP_LOC100702329.1.1 m.25333 sp ZN277_HUMAN 49.169 421 199 6 8 425 36 444 6.93E-141 413 ZN277_HUMAN reviewed Zinc finger protein 277 (Nuclear receptor-interacting factor 4) ZNF277 NRIF4 ZNF277P Homo sapiens (Human) 450 "cellular response to hydrogen peroxide [GO:0070301]; regulation of cellular senescence [GO:2000772]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000979; GO:0005634; GO:0006351; GO:0006355; GO:0046872; GO:0070301; GO:2000772 0 0 0 PF12756; Q9UKK3 CHOYP_LOC100373327.7.13 m.37959 sp PARP4_HUMAN 29.63 135 88 2 103 237 178 305 6.93E-09 59.3 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; A5A8Y8 CHOYP_EGFL7.1.1 m.25013 sp EGFL8_PIG 36.047 258 147 9 36 283 33 282 6.94E-39 141 EGFL8_PIG reviewed Epidermal growth factor-like protein 8 (EGF-like protein 8) EGFL8 Sus scrofa (Pig) 295 0 GO:0005509; GO:0005576 0 0 0 PF00008;PF07645;PF07546; O13997 CHOYP_BRAFLDRAFT_199990.2.3 m.64106 sp YIH1_SCHPO 32.979 94 61 2 3 94 155 248 6.94E-09 54.7 YIH1_SCHPO reviewed Protein IMPACT homolog yih1 SPAC27E2.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 280 cellular response to acidic pH [GO:0071468]; cellular response to amino acid starvation [GO:0034198]; cellular response to benomyl [GO:0072755]; cellular response to hydrogen peroxide [GO:0070301]; negative regulation of cell death [GO:0060548]; regulation of cytoplasmic translation in response to stress [GO:1990497] GO:0005634; GO:0005737; GO:0034198; GO:0060548; GO:0070301; GO:0071468; GO:0072755; GO:1990497 0 0 0 PF05773;PF01205; O15031 CHOYP_PLXNB2.3.4 m.54963 sp PLXB2_HUMAN 21.569 357 212 14 1 323 222 544 6.94E-12 71.6 PLXB2_HUMAN reviewed Plexin-B2 (MM1) PLXNB2 KIAA0315 Homo sapiens (Human) 1838 brain development [GO:0007420]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0001843; GO:0001932; GO:0002116; GO:0005887; GO:0007156; GO:0007162; GO:0007405; GO:0007420; GO:0008360; GO:0009986; GO:0010976; GO:0017154; GO:0030334; GO:0043087; GO:0050772; GO:0070062; GO:0071526; GO:1902287; GO:2001222 0 0 0 PF08337;PF01437;PF01403;PF01833; P18101 CHOYP_LOC100695843.2.4 m.24142 sp RL40_DROME 97.656 128 3 0 1 128 1 128 6.94E-90 259 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; P18101 CHOYP_LOC101209425.2.2 m.39583 sp RL40_DROME 97.656 128 3 0 1 128 1 128 6.94E-90 259 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; P42530 CHOYP_BRAFLDRAFT_74119.1.1 m.4909 sp DIS2_DICDI 36.62 71 44 1 155 224 185 255 6.94E-06 49.3 DIS2_DICDI reviewed Discoidin-2 (Discoidin II) dscE DDB_G0292552 Dictyostelium discoideum (Slime mold) 257 cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; response to bacterium [GO:0009617] GO:0007155; GO:0009617; GO:0016936; GO:0030246; GO:0030247; GO:0031982; GO:0045335; GO:0046871; GO:0046872; GO:0070492; GO:0098609 0 0 0 PF00754;PF09458; P48725 CHOYP_LOC582174.11.16 m.42018 sp PCNT_MOUSE 52.294 109 46 2 47 151 2683 2789 6.94E-32 124 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; Q08257 CHOYP_CRYZ.2.2 m.65927 sp QOR_HUMAN 53.583 321 149 0 10 330 7 327 6.94E-123 358 QOR_HUMAN reviewed Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin) CRYZ Homo sapiens (Human) 329 protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178] GO:0003730; GO:0003960; GO:0005737; GO:0005829; GO:0007601; GO:0008270; GO:0042178; GO:0051289; GO:0070062; GO:0070402 0 0 0 PF08240;PF00107; Q1LZ75 CHOYP_ERCC1.1.1 m.17678 sp ERCC1_BOVIN 56.863 255 107 2 66 318 38 291 6.94E-104 309 ERCC1_BOVIN reviewed DNA excision repair protein ERCC-1 ERCC1 Bos taurus (Bovine) 294 "cell proliferation [GO:0008283]; double-strand break repair [GO:0006302]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; male gonad development [GO:0008584]; mitotic recombination [GO:0006312]; multicellular organism aging [GO:0010259]; multicellular organism growth [GO:0035264]; negative regulation of telomere maintenance [GO:0032205]; nucleotide-excision repair, DNA incision, 3'-to lesion [GO:0006295]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; oogenesis [GO:0048477]; positive regulation of t-circle formation [GO:1904431]; post-embryonic hemopoiesis [GO:0035166]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; replicative cell aging [GO:0001302]; response to oxidative stress [GO:0006979]; response to X-ray [GO:0010165]; spermatogenesis [GO:0007283]; syncytium formation [GO:0006949]; t-circle formation [GO:0090656]; UV protection [GO:0009650]" GO:0000014; GO:0000109; GO:0000110; GO:0000720; GO:0000784; GO:0001302; GO:0003684; GO:0003697; GO:0005669; GO:0005737; GO:0006295; GO:0006296; GO:0006302; GO:0006312; GO:0006949; GO:0006979; GO:0007283; GO:0008022; GO:0008283; GO:0008584; GO:0009650; GO:0010165; GO:0010259; GO:0032205; GO:0035166; GO:0035264; GO:0036297; GO:0043566; GO:0045190; GO:0048477; GO:0070522; GO:0090656; GO:1904431 0 0 0 0 Q28824 CHOYP_MYLK.1.4 m.1549 sp MYLK_BOVIN 52.941 119 47 2 1 111 923 1040 6.94E-32 125 MYLK_BOVIN reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" MYLK Bos taurus (Bovine) 1176 positive regulation of cell migration [GO:0030335]; smooth muscle contraction [GO:0006939] GO:0004687; GO:0005524; GO:0005737; GO:0005856; GO:0006939; GO:0030027; GO:0030335; GO:0032154; GO:0046872 0 0 0 PF00041;PF07679;PF00069; Q297L2 CHOYP_NRBP.1.1 m.44745 sp NRBP_DROPS 67.123 73 24 0 33 105 93 165 6.94E-26 106 NRBP_DROPS reviewed Nuclear receptor-binding protein homolog (MLF1-adaptor molecule) Madm GA10685 Drosophila pseudoobscura pseudoobscura (Fruit fly) 663 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0004672; GO:0005524; GO:0005938; GO:0006888; GO:0012505; GO:0042803 0 0 0 PF07714; Q2TBW5 CHOYP_LOC101242714.1.1 m.66103 sp ZNHI2_BOVIN 25.915 355 199 10 39 354 16 345 6.94E-30 122 ZNHI2_BOVIN reviewed Zinc finger HIT domain-containing protein 2 ZNHIT2 Bos taurus (Bovine) 399 0 GO:0046872 0 0 0 PF04438; Q4UMH6 CHOYP_LOC755594.5.6 m.54446 sp Y381_RICFE 24.219 384 234 13 336 688 627 984 6.94E-15 82.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q58D65 CHOYP_TYW2.1.1 m.34772 sp TYW2_BOVIN 45.843 445 213 10 27 466 12 433 6.94E-124 370 TYW2_BOVIN reviewed tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase) TRMT12 TYW2 Bos taurus (Bovine) 438 tRNA processing [GO:0008033] GO:0008033; GO:0016740 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 PF02475; Q68VK5 CHOYP_TSPAN3.1.1 m.37480 sp TSN5_RAT 24.324 259 180 5 8 261 14 261 6.94E-18 84.3 TSN5_RAT reviewed Tetraspanin-5 (Tspan-5) (Transmembrane 4 superfamily member 9) Tspan5 Tm4sf9 Rattus norvegicus (Rat) 268 cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to plasma membrane [GO:0090002]; positive regulation of Notch signaling pathway [GO:0045747]; protein maturation [GO:0051604] GO:0005887; GO:0007155; GO:0007166; GO:0008283; GO:0016021; GO:0045747; GO:0051604; GO:0090002 0 0 0 PF00335; Q6TXF1 CHOYP_ARRD-6.1.1 m.9470 sp ARRD3_RAT 28.662 314 204 8 1 307 13 313 6.94E-40 152 ARRD3_RAT reviewed Arrestin domain-containing protein 3 (Liver regeneration-related protein LRRG00048) Arrdc3 Rattus norvegicus (Rat) 414 fat pad development [GO:0060613]; negative regulation of heat generation [GO:0031651]; negative regulation of locomotion involved in locomotory behavior [GO:0090327]; negative regulation of multicellular organismal metabolic process [GO:0044252]; positive regulation of adrenergic receptor signaling pathway [GO:0071879]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; skin development [GO:0043588]; temperature homeostasis [GO:0001659] GO:0001659; GO:0005764; GO:0005769; GO:0005886; GO:0031651; GO:0043588; GO:0044252; GO:0051443; GO:0060613; GO:0071879; GO:0090327 0 0 0 PF02752;PF00339; Q75WF2 CHOYP_DNA2.2.5 m.21231 sp DNA2_ACAPL 33.803 355 211 11 5 339 7 357 6.94E-54 183 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q8N7B6 CHOYP_PACRL.1.1 m.9926 sp PACRL_HUMAN 62.105 190 72 0 41 230 57 246 6.94E-87 260 PACRL_HUMAN reviewed PACRG-like protein PACRGL C4orf28 Homo sapiens (Human) 248 0 0 0 0 0 PF10274; Q8R015 CHOYP_BL1S5.1.1 m.16481 sp BL1S5_MOUSE 35.374 147 92 1 5 148 33 179 6.94E-23 92 BL1S5_MOUSE reviewed Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) Bloc1s5 Mu Muted Mus musculus (Mouse) 185 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; developmental pigmentation [GO:0048066]; endosomal transport [GO:0016197]; endosome to melanosome transport [GO:0035646]; melanosome transport [GO:0032402]; neuron projection development [GO:0031175]; otolith morphogenesis [GO:0032474]; positive regulation of pigment cell differentiation [GO:0050942]; vesicle-mediated transport [GO:0016192] GO:0008089; GO:0016192; GO:0016197; GO:0030133; GO:0031083; GO:0031175; GO:0032402; GO:0032474; GO:0035646; GO:0048066; GO:0048490; GO:0050942; GO:1904115 0 0 0 PF14942; Q8R3W5 CHOYP_EF1B.3.7 m.35083 sp SEN15_MOUSE 31.373 102 67 1 1 99 64 165 6.94E-08 52 SEN15_MOUSE reviewed tRNA-splicing endonuclease subunit Sen15 (tRNA-intron endonuclease Sen15) Tsen15 Sen15 Mus musculus (Mouse) 168 "mRNA processing [GO:0006397]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000213; GO:0005730; GO:0006388; GO:0006397 0 0 0 PF09631; Q98943 CHOYP_LOC100888891.1.2 m.369 sp CASP2_CHICK 34.259 108 71 0 946 1053 3 110 6.94E-10 66.2 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q98SN7 CHOYP_WN10A.1.1 m.28564 sp WNT2B_CHICK 46.708 319 158 5 77 387 60 374 6.94E-99 301 WNT2B_CHICK reviewed Protein Wnt-2b WNT2B Gallus gallus (Chicken) 385 camera-type eye photoreceptor cell differentiation [GO:0060219]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell proliferation [GO:0008283]; cornea development in camera-type eye [GO:0061303]; embryonic camera-type eye formation [GO:0060900]; embryonic forelimb morphogenesis [GO:0035115]; iris morphogenesis [GO:0061072]; lens development in camera-type eye [GO:0002088]; limb development [GO:0060173]; morphogenesis of an epithelial sheet [GO:0002011]; negative regulation of glial cell differentiation [GO:0045686]; negative regulation of neuron differentiation [GO:0045665]; neural retina development [GO:0003407]; neuron differentiation [GO:0030182]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of fibroblast growth factor production [GO:0090270]; retina layer formation [GO:0010842]; Wnt signaling pathway [GO:0016055] GO:0002011; GO:0002088; GO:0003407; GO:0005109; GO:0005578; GO:0005615; GO:0008283; GO:0010842; GO:0016055; GO:0030182; GO:0035115; GO:0045165; GO:0045665; GO:0045686; GO:0045743; GO:0060070; GO:0060173; GO:0060219; GO:0060828; GO:0060900; GO:0061072; GO:0061303; GO:0090270; GO:0090271 0 0 0 PF00110; Q99MU5 CHOYP_SPATA6.1.1 m.20218 sp SPAT6_RAT 29.221 462 243 17 1 426 1 414 6.94E-35 139 SPAT6_RAT reviewed Spermatogenesis-associated protein 6 (Kinesin-related protein) (Spermatogenesis-related factor 1) Spata6 Hash Srf1 Rattus norvegicus (Rat) 488 cell differentiation [GO:0030154]; motile cilium assembly [GO:0044458]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005576; GO:0007275; GO:0007283; GO:0030154; GO:0044458; GO:0097224 0 0 0 PF14909; A0JC51 CHOYP_BRAFLDRAFT_277895.1.1 m.40349 sp ZIC4_XENLA 52.061 461 148 14 14 444 87 504 6.95E-136 405 ZIC4_XENLA reviewed Zinc finger protein ZIC 4 (XlZic4) (Zinc finger protein of the cerebellum 4) zic4 Xenopus laevis (African clawed frog) 530 nervous system development [GO:0007399]; neural crest formation [GO:0014029] GO:0003677; GO:0005634; GO:0007399; GO:0014029; GO:0046872 0 0 0 PF00096; O05218 CHOYP_NEMVEDRAFT_V1G169538.1.2 m.18155 sp YWRD_BACSU 38.514 296 172 4 17 311 4 290 6.95E-56 192 YWRD_BACSU reviewed Putative gamma-glutamyltransferase YwrD (EC 2.3.2.2) (Glutathione hydrolase) (EC 3.4.19.13) [Cleaved into: Gamma-glutamyltranspeptidase large chain; Gamma-glutamyltranspeptidase small chain] ywrD BSU36100 Bacillus subtilis (strain 168) 525 glutathione metabolic process [GO:0006749] GO:0003840; GO:0006749; GO:0036374 0 0 0 PF01019; P28828 CHOYP_PTPRT.14.45 m.40941 sp PTPRM_MOUSE 37.429 350 210 6 2 345 949 1295 6.95E-75 256 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; P29590 CHOYP_LOC100373888.9.9 m.66033 sp PML_HUMAN 25.51 392 233 15 54 420 31 388 6.95E-18 92 PML_HUMAN reviewed Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) 882 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006915; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0016925; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045892; GO:0045930; GO:0046982; GO:0048146; GO:0048384; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060333; GO:0060444; GO:0070059; GO:0071353; GO:0090398; GO:0097191; GO:1901796; GO:1902187; GO:1904816; GO:2000059; GO:2000779; GO:2001238 0 0 0 PF12126;PF00643; P55041 CHOYP_LOC100865163.1.5 m.16342 sp GEM_MOUSE 31.624 234 139 5 90 305 45 275 6.95E-25 104 GEM_MOUSE reviewed GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) Gem Kir Mus musculus (Mouse) 295 chromosome organization [GO:0051276]; metaphase plate congression [GO:0051310]; mitotic nuclear division [GO:0007067]; small GTPase mediated signal transduction [GO:0007264] GO:0000287; GO:0003924; GO:0005525; GO:0005634; GO:0007067; GO:0007264; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686 0 0 0 PF00071; P69098 CHOYP_LNX2.1.1 m.32077 sp CALM_TRYBG 48 150 74 2 1 150 1 146 6.95E-39 132 CALM_TRYBG reviewed Calmodulin (CaM) 0 Trypanosoma brucei gambiense 149 0 GO:0005509 0 0 0 PF13499; Q16769 CHOYP_QPCT.1.1 m.38977 sp QPCT_HUMAN 42.722 316 163 5 31 330 48 361 6.95E-79 248 QPCT_HUMAN reviewed Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC) QPCT Homo sapiens (Human) 361 "cellular protein modification process [GO:0006464]; peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]" GO:0006464; GO:0008270; GO:0016603; GO:0017186; GO:0070062 0 0 0 PF04389; Q17QL9 CHOYP_T184C.1.2 m.14169 sp T184C_BOVIN 56.316 190 78 3 192 378 192 379 6.95E-68 228 T184C_BOVIN reviewed Transmembrane protein 184C (Transmembrane protein 34) TMEM184C TMEM34 Bos taurus (Bovine) 438 transport [GO:0006810] GO:0005215; GO:0006810; GO:0016021 0 0 0 PF03619; Q24400 CHOYP_MLP2.1.4 m.30871 sp MLP2_DROME 51.163 129 61 1 2 130 9 135 6.95E-31 117 MLP2_DROME reviewed Muscle LIM protein Mlp84B Mlp84B LIM3 CG10699 Drosophila melanogaster (Fruit fly) 495 muscle organ development [GO:0007517]; muscle tissue development [GO:0060537]; regulation of establishment of planar polarity [GO:0090175]; sarcomere organization [GO:0045214] GO:0005634; GO:0007517; GO:0008270; GO:0008307; GO:0030018; GO:0045214; GO:0060537; GO:0090175 0 0 0 PF00412; Q4KMZ8 CHOYP_NKAIN.1.1 m.13995 sp NKAI1_HUMAN 47.753 178 80 4 18 191 9 177 6.95E-52 172 NKAI1_HUMAN reviewed Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1 (Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1) (Protein FAM77C) NKAIN1 FAM77C Homo sapiens (Human) 207 regulation of sodium ion transport [GO:0002028] GO:0002028; GO:0005886; GO:0016021 0 0 0 PF05640; Q504A5 CHOYP_LOC100369695.1.1 m.26973 sp TPMT_DANRE 42.793 222 127 0 22 243 9 230 6.95E-64 201 TPMT_DANRE reviewed Probable thiopurine S-methyltransferase (Thiopurine methyltransferase) (EC 2.1.1.67) tpmt zgc:109981 Danio rerio (Zebrafish) (Brachydanio rerio) 232 nucleobase-containing compound metabolic process [GO:0006139] GO:0005737; GO:0006139; GO:0008119 0 0 0 PF05724; Q54KA7 CHOYP_TVAG_332510.2.2 m.65826 sp SECG_DICDI 27.857 420 255 8 27 444 63 436 6.95E-36 147 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q6PCJ9 CHOYP_LOC101072178.1.1 m.65566 sp PPT2A_XENLA 53.358 268 123 2 37 302 28 295 6.95E-101 300 PPT2A_XENLA reviewed Lysosomal thioesterase PPT2-A (PPT-2-A) (EC 3.1.2.-) ppt2-a Xenopus laevis (African clawed frog) 296 0 GO:0005764; GO:0008474 0 0 0 PF02089; Q71R50 CHOYP_LOC101167642.1.1 m.31028 sp DHR11_CHICK 60.392 255 98 2 1 252 1 255 6.95E-110 320 DHR11_CHICK reviewed Dehydrogenase/reductase SDR family member 11 (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 24C member 1) DHRS11 SDR24C1 Gallus gallus (Chicken) 255 0 GO:0005576; GO:0016491 0 0 0 PF00106; Q8VHK0 CHOYP_LOC100712267.1.1 m.22190 sp ACOT8_RAT 44.983 289 155 3 43 330 27 312 6.95E-85 261 ACOT8_RAT reviewed Acyl-coenzyme A thioesterase 8 (Acyl-CoA thioesterase 8) (EC 3.1.2.27) (Choloyl-coenzyme A thioesterase) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-CoA thioesterase 1) Acot8 Pte1 Pte2 Rattus norvegicus (Rat) 320 acyl-CoA metabolic process [GO:0006637]; negative regulation of CD4 biosynthetic process [GO:0045225]; peroxisome organization [GO:0007031] GO:0005782; GO:0006637; GO:0007031; GO:0016290; GO:0033882; GO:0045225; GO:0052689; GO:0052815 0 0 0 0 Q96PX1 CHOYP_LOC659409.1.1 m.24437 sp RN157_HUMAN 54.026 385 157 10 1 374 1 376 6.95E-132 405 RN157_HUMAN reviewed RING finger protein 157 RNF157 KIAA1917 Homo sapiens (Human) 679 0 GO:0008270 0 0 0 0 Q9ESN6 CHOYP_TRIM3.37.58 m.39048 sp TRIM2_MOUSE 28.085 235 148 11 124 348 483 706 6.95E-17 85.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A0JM12 CHOYP_MEGF10.9.12 m.42129 sp MEG10_XENTR 39.431 246 132 9 216 460 601 830 6.96E-36 145 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; F6QEU4 CHOYP_LOC100368020.7.29 m.17532 sp LIN41_XENTR 20.796 226 124 7 4 198 136 337 6.96E-06 50.1 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; O74423 CHOYP_LOC101067880.1.1 m.26958 sp ENT1_SCHPO 29.31 116 79 2 173 287 323 436 6.96E-11 67 ENT1_SCHPO reviewed Epsin-1 ent1 SPCC162.07 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 702 actin filament organization [GO:0007015]; endocytosis [GO:0006897]; positive regulation of GTPase activity [GO:0043547] GO:0005546; GO:0006897; GO:0007015; GO:0016020; GO:0030479; GO:0043547 0 0 0 PF08226;PF01417; O95972 CHOYP_CBR-TIG-3.1.1 m.14842 sp BMP15_HUMAN 30.088 113 71 3 261 373 286 390 6.96E-07 54.3 BMP15_HUMAN reviewed Bone morphogenetic protein 15 (BMP-15) (Growth/differentiation factor 9B) (GDF-9B) BMP15 GDF9B Homo sapiens (Human) 392 BMP signaling pathway [GO:0030509]; cell development [GO:0048468]; female gamete generation [GO:0007292]; granulosa cell development [GO:0060016]; ovarian follicle development [GO:0001541]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; regulation of apoptotic process [GO:0042981]; regulation of MAPK cascade [GO:0043408]; SMAD protein signal transduction [GO:0060395] GO:0001541; GO:0005125; GO:0005160; GO:0005615; GO:0005737; GO:0007292; GO:0010862; GO:0030509; GO:0042981; GO:0043408; GO:0048468; GO:0060016; GO:0060395 0 0 0 PF00019; P16330 CHOYP_CN37.1.1 m.40698 sp CN37_MOUSE 27.564 156 93 5 54 201 236 379 6.96E-11 64.3 CN37_MOUSE reviewed "2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)" Cnp Cnp1 Mus musculus (Mouse) 420 adult locomotory behavior [GO:0008344]; aging [GO:0007568]; axonogenesis [GO:0007409]; cyclic nucleotide catabolic process [GO:0009214]; forebrain development [GO:0030900]; microtubule cytoskeleton organization [GO:0000226]; oligodendrocyte differentiation [GO:0048709]; regulation of mitochondrial membrane permeability [GO:0046902]; response to lipopolysaccharide [GO:0032496]; response to toxic substance [GO:0009636]; substantia nigra development [GO:0021762] GO:0000226; GO:0003723; GO:0004113; GO:0005615; GO:0005634; GO:0005654; GO:0005737; GO:0005741; GO:0005743; GO:0005874; GO:0005886; GO:0005902; GO:0007409; GO:0007568; GO:0008344; GO:0009214; GO:0009636; GO:0016020; GO:0021762; GO:0030551; GO:0030900; GO:0031143; GO:0032496; GO:0035748; GO:0035749; GO:0042470; GO:0043209; GO:0046902; GO:0048471; GO:0048709; GO:0070062 0 0 0 PF05881; Q08D62 CHOYP_BRAFLDRAFT_121310.1.1 m.45682 sp MAEL_XENTR 30.508 354 206 11 1 329 1 339 6.96E-42 159 MAEL_XENTR reviewed Protein maelstrom homolog mael Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 415 "cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283]" GO:0005634; GO:0005737; GO:0007140; GO:0007275; GO:0007283; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:0043186; GO:0043565; GO:0045892; GO:0071547 0 0 0 PF09011;PF13017; Q0VA04 CHOYP_SMG8.1.1 m.59173 sp SMG8_XENTR 43.06 562 297 10 32 575 24 580 6.96E-134 430 SMG8_XENTR reviewed Protein smg8 (Protein smg-8 homolog) smg8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 915 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of protein kinase activity [GO:0045859]" GO:0000184; GO:0045859 0 0 0 PF10220; Q2HJ98 CHOYP_PIGS.1.1 m.18959 sp FAHD1_BOVIN 55.814 215 95 0 2 216 3 217 6.96E-92 271 FAHD1_BOVIN reviewed "Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.3)" FAHD1 Bos taurus (Bovine) 221 metabolic process [GO:0008152] GO:0005654; GO:0005739; GO:0005743; GO:0005829; GO:0008152; GO:0008948; GO:0018773; GO:0034545; GO:0046872; GO:0047621 0 0 0 PF01557; Q2Q1W2 CHOYP_contig_008262 m.9576 sp LIN41_HUMAN 27.907 172 103 6 748 915 656 810 6.96E-07 57 LIN41_HUMAN reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Homo sapiens (Human) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0017148; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; Q60787 CHOYP_LCP2.11.14 m.35901 sp LCP2_MOUSE 36.296 135 83 2 481 612 389 523 6.96E-19 94 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q6Y1H2 CHOYP_HACD2.1.1 m.33344 sp HACD2_HUMAN 53.571 224 104 0 48 271 28 251 6.96E-77 236 HACD2_HUMAN reviewed Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B) HACD2 PTPLB Homo sapiens (Human) 254 fatty acid elongation [GO:0030497]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; very long-chain fatty acid biosynthetic process [GO:0042761] GO:0005783; GO:0005789; GO:0016021; GO:0018812; GO:0019899; GO:0030148; GO:0030497; GO:0035338; GO:0042761; GO:0080023; GO:0102344; GO:0102345 PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:18554506}. 0 0 PF04387; Q75WF2 CHOYP_DNS2A.1.2 m.57063 sp DNA2_ACAPL 35.117 299 174 8 9 292 64 357 6.96E-49 169 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q8MRC9 CHOYP_GALT5.2.2 m.40435 sp GALT9_DROME 52.063 315 136 7 11 315 269 578 6.96E-107 329 GALT9_DROME reviewed Putative polypeptide N-acetylgalactosaminyltransferase 9 (pp-GaNTase 9) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 9) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 9) pgant9 CG30463 Drosophila melanogaster (Fruit fly) 650 multicellular organism reproduction [GO:0032504]; protein O-linked glycosylation [GO:0006493] GO:0000139; GO:0004653; GO:0005794; GO:0005829; GO:0006493; GO:0016021; GO:0030246; GO:0031985; GO:0032504; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q9D0C1 CHOYP_LOC100374633.2.2 m.43395 sp RN115_MOUSE 38.356 292 144 7 33 302 19 296 6.96E-59 194 RN115_MOUSE reviewed E3 ubiquitin-protein ligase RNF115 (EC 6.3.2.-) (RING finger protein 115) (Rabring 7) (Zinc finger protein 364) Rnf115 Zfp364 Znf364 Mus musculus (Mouse) 305 negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0042059; GO:0042787; GO:0043161; GO:0043162; GO:0051865; GO:0061630; GO:0070534; GO:0070936 "PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:17462600, ECO:0000269|PubMed:23418353}." 0 0 PF13639; Q9D114 CHOYP_MESH1.3.3 m.60138 sp MESH1_MOUSE 65.896 173 59 0 6 178 3 175 6.96E-84 249 MESH1_MOUSE reviewed "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)" Hddc3 Mesh1 Mus musculus (Mouse) 179 guanosine tetraphosphate metabolic process [GO:0015969]; response to starvation [GO:0042594] GO:0008728; GO:0008893; GO:0015969; GO:0042594; GO:0046872 0 0 0 PF13328; E1BJS7 CHOYP_BRAFLDRAFT_88223.14.22 m.53289 sp LIN41_BOVIN 21.277 517 311 18 9 499 270 716 6.97E-12 71.6 LIN41_BOVIN reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) TRIM71 LIN41 Bos taurus (Bovine) 868 3'-UTR-mediated mRNA destabilization [GO:0061158]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; positive regulation of gene silencing by miRNA [GO:2000637]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0001843; GO:0004842; GO:0008270; GO:0008543; GO:0010586; GO:0016874; GO:0021915; GO:0030371; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0061158; GO:0061630; GO:0072089; GO:2000177; GO:2000637 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; F1N6G5 CHOYP_LOC100635111.3.13 m.3894 sp HACE1_BOVIN 32.867 143 77 3 501 626 69 209 6.97E-08 59.7 HACE1_BOVIN reviewed E3 ubiquitin-protein ligase HACE1 (EC 2.3.2.26) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1) (HECT-type E3 ubiquitin transferase HACE1) HACE1 Bos taurus (Bovine) 909 "cell cycle [GO:0007049]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cell migration [GO:0030334]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000139; GO:0004842; GO:0005634; GO:0005737; GO:0005783; GO:0006351; GO:0006355; GO:0007030; GO:0007049; GO:0016567; GO:0016874; GO:0017137; GO:0030334; GO:0032580; GO:0042787; GO:0061025; GO:0070936 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF00632; O00370 CHOYP_LOC100495383.1.1 m.6949 sp LORF2_HUMAN 25.09 279 198 7 1 277 77 346 6.97E-18 87.8 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; P28651 CHOYP_CAH8.1.1 m.28886 sp CAH8_MOUSE 53.704 270 110 3 24 293 37 291 6.97E-100 297 CAH8_MOUSE reviewed Carbonic anhydrase-related protein (CARP) (Carbonic anhydrase VIII) (CA-VIII) Ca8 Cals Cals1 Car8 Carp Mus musculus (Mouse) 291 one-carbon metabolic process [GO:0006730]; phosphatidylinositol-mediated signaling [GO:0048015] GO:0004089; GO:0005737; GO:0006730; GO:0008270; GO:0048015 0 0 0 PF00194; P86221 CHOYP_TBB2.2.2 m.53005 sp TBB4B_MESAU 98.148 54 1 0 32 85 34 87 6.97E-32 116 TBB4B_MESAU reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) (Fragments) TUBB4B TUBB2C Mesocricetus auratus (Golden hamster) 290 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091; Q28IT1 CHOYP_LOC100378550.1.1 m.11149 sp ERLEC_XENTR 43.091 427 227 8 48 468 61 477 6.97E-116 352 ERLEC_XENTR reviewed Endoplasmic reticulum lectin 1 (ER lectin) (Erlectin) erlec1 TNeu121c15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 481 "ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; retrograde protein transport, ER to cytosol [GO:0030970]" GO:0001948; GO:0005788; GO:0030433; GO:0030970 0 0 0 PF07915; Q68EM7 CHOYP_RHG17.1.2 m.32098 sp RHG17_HUMAN 50.327 459 219 5 7 460 1 455 6.97E-152 466 RHG17_HUMAN reviewed Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1) ARHGAP17 RICH1 MSTP066 MSTP110 Homo sapiens (Human) 881 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0005886; GO:0005923; GO:0007165; GO:0051056 0 0 0 PF03114;PF00620; Q7LHG5 CHOYP_LOC754701.4.7 m.15951 sp YI31B_YEAST 37.329 292 163 8 82 361 550 833 6.97E-53 192 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q8BN59 CHOYP_BRAFLDRAFT_125729.1.1 m.50316 sp LARP6_MOUSE 32.37 519 243 17 50 551 65 492 6.97E-56 198 LARP6_MOUSE reviewed La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6) Larp6 Mus musculus (Mouse) 492 regulation of translation [GO:0006417]; RNA processing [GO:0006396] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006396; GO:0006417; GO:0030529 0 0 0 PF05383;PF12901; Q95LU3 CHOYP_BRAFLDRAFT_88596.1.2 m.24206 sp FBCD1_MACFA 33.233 331 195 8 19 325 98 426 6.97E-53 182 FBCD1_MACFA reviewed Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 431 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q9R1B9 CHOYP_SLIK1.1.1 m.57866 sp SLIT2_MOUSE 39.394 99 54 1 1 99 613 705 6.97E-14 71.6 SLIT2_MOUSE reviewed Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] Slit2 Mus musculus (Mouse) 1521 axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; central nervous system projection neuron axonogenesis [GO:0021952]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; dorsal/ventral axon guidance [GO:0033563]; induction of negative chemotaxis [GO:0050929]; in utero embryonic development [GO:0001701]; mammary duct terminal end bud growth [GO:0060763]; mammary gland duct morphogenesis [GO:0060603]; metanephros development [GO:0001656]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of axon extension [GO:0030517]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of gene expression [GO:0010629]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; positive regulation of apoptotic process [GO:0043065]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; single organismal cell-cell adhesion [GO:0016337]; telencephalon cell migration [GO:0022029]; ureteric bud development [GO:0001657] GO:0001656; GO:0001657; GO:0001701; GO:0001933; GO:0002042; GO:0002689; GO:0005095; GO:0005102; GO:0005509; GO:0005578; GO:0005615; GO:0005737; GO:0007409; GO:0007411; GO:0008045; GO:0008201; GO:0008285; GO:0010593; GO:0010596; GO:0010629; GO:0014912; GO:0016337; GO:0021772; GO:0021836; GO:0021952; GO:0021972; GO:0022029; GO:0030308; GO:0030336; GO:0030517; GO:0030837; GO:0031290; GO:0033563; GO:0035385; GO:0042802; GO:0042803; GO:0043065; GO:0043116; GO:0043237; GO:0043394; GO:0045499; GO:0048495; GO:0048754; GO:0048812; GO:0048846; GO:0050919; GO:0050929; GO:0051058; GO:0060603; GO:0060763; GO:0070062; GO:0070100; GO:0071504; GO:0071672; GO:0071676; GO:0090024; GO:0090260; GO:0090288 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; Q9Y3Z3 CHOYP_SAMH1.8.12 m.45701 sp SAMH1_HUMAN 39.112 473 233 10 4 454 116 555 6.97E-100 316 SAMH1_HUMAN reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) SAMHD1 MOP5 Homo sapiens (Human) 626 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; immune response [GO:0006955]; protein homotetramerization [GO:0051289]; regulation of innate immune response [GO:0045088]; type I interferon signaling pathway [GO:0060337] GO:0003676; GO:0003723; GO:0005622; GO:0005634; GO:0005654; GO:0005886; GO:0006203; GO:0006955; GO:0008270; GO:0008832; GO:0032567; GO:0045088; GO:0046061; GO:0051289; GO:0051607; GO:0060337 0 0 0 PF01966;PF07647; A1E295 CHOYP_CATB.2.2 m.40747 sp CATB_PIG 56.15 187 73 4 49 233 14 193 6.98E-71 223 CATB_PIG reviewed Cathepsin B (EC 3.4.22.1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] CTSB Sus scrofa (Pig) 335 cellular response to thyroid hormone stimulus [GO:0097067]; collagen catabolic process [GO:0030574]; decidualization [GO:0046697]; epithelial cell differentiation [GO:0030855]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of catalytic activity [GO:0050790]; viral entry into host cell [GO:0046718] GO:0004197; GO:0005615; GO:0005730; GO:0005739; GO:0005764; GO:0030574; GO:0030855; GO:0042470; GO:0043394; GO:0046697; GO:0046718; GO:0048471; GO:0050790; GO:0051603; GO:0070062; GO:0097067 0 0 0 PF00112;PF08127; A2RRH5 CHOYP_LOC100888253.1.1 m.18761 sp WDR27_HUMAN 34.271 782 418 14 5 778 131 824 6.98E-135 423 WDR27_HUMAN reviewed WD repeat-containing protein 27 WDR27 Homo sapiens (Human) 827 0 GO:0005654 0 0 0 PF00400; H2A0P0 CHOYP_LOC100228168.1.1 m.17974 sp KCP5_PINMG 44.554 101 48 3 125 219 47 145 6.98E-20 89.7 KCP5_PINMG reviewed BPTI/Kunitz domain-containing protein 5 (Nacre serine protease inhibitor 5) 0 Pinctada margaritifera (Black-lipped pearl oyster) 182 0 GO:0004867; GO:0005576 0 0 0 PF00014; O60921 CHOYP_HUS1.1.1 m.6271 sp HUS1_HUMAN 56.294 286 119 1 1 286 1 280 6.98E-117 340 HUS1_HUMAN reviewed Checkpoint protein HUS1 (hHUS1) HUS1 Homo sapiens (Human) 280 cellular response to DNA damage stimulus [GO:0006974]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; embryo development [GO:0009790]; intra-S DNA damage checkpoint [GO:0031573]; meiotic DNA integrity checkpoint [GO:0044778]; mitotic DNA replication checkpoint [GO:0033314]; negative regulation of DNA replication [GO:0008156]; nucleotide-excision repair [GO:0006289]; protein phosphorylation [GO:0006468]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to UV [GO:0009411] GO:0000077; GO:0000724; GO:0001932; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006260; GO:0006281; GO:0006289; GO:0006468; GO:0006974; GO:0008156; GO:0009411; GO:0009790; GO:0030896; GO:0031573; GO:0033314; GO:0035861; GO:0044778; GO:0071479; GO:1901796 0 0 0 PF04005; O70277 CHOYP_BRAFLDRAFT_87325.5.11 m.20592 sp TRIM3_RAT 24.26 169 103 5 5 164 535 687 6.98E-08 54.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O88281 CHOYP_TSP_08596.1.1 m.5512 sp MEGF6_RAT 41.786 280 141 3 1 264 1046 1319 6.98E-58 202 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P16591 CHOYP_ISCW_ISCW019316.1.1 m.51174 sp FER_HUMAN 35.417 480 266 13 177 623 352 820 6.98E-77 264 FER_HUMAN reviewed Tyrosine-protein kinase Fer (EC 2.7.10.2) (Feline encephalitis virus-related kinase FER) (Fujinami poultry sarcoma/Feline sarcoma-related protein Fer) (Proto-oncogene c-Fer) (Tyrosine kinase 3) (p94-Fer) FER TYK3 Homo sapiens (Human) 822 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cellular response to insulin stimulus [GO:0032869]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to reactive oxygen species [GO:0034614]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; diapedesis [GO:0050904]; extracellular matrix-cell signaling [GO:0035426]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; insulin receptor signaling pathway via phosphatidylinositol 3-kinase [GO:0038028]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; Kit signaling pathway [GO:0038109]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; negative regulation of mast cell activation involved in immune response [GO:0033007]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of fibroblast migration [GO:0010762]; regulation of lamellipodium assembly [GO:0010591]; regulation of mast cell degranulation [GO:0043304]; regulation of protein phosphorylation [GO:0001932]; response to lipopolysaccharide [GO:0032496]; response to platelet-derived growth factor [GO:0036119]; substrate adhesion-dependent cell spreading [GO:0034446]; tyrosine phosphorylation of Stat3 protein [GO:0042503] GO:0000226; GO:0000278; GO:0001932; GO:0004713; GO:0004715; GO:0005154; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005938; GO:0006468; GO:0006935; GO:0007155; GO:0008283; GO:0008284; GO:0008289; GO:0010591; GO:0010762; GO:0018108; GO:0019221; GO:0030054; GO:0030154; GO:0030335; GO:0030838; GO:0031234; GO:0031532; GO:0032496; GO:0032869; GO:0033007; GO:0034446; GO:0034614; GO:0035426; GO:0035556; GO:0036006; GO:0036119; GO:0038028; GO:0038083; GO:0038095; GO:0038109; GO:0042058; GO:0042503; GO:0042995; GO:0043304; GO:0044331; GO:0045087; GO:0046777; GO:0048008; GO:0050904; GO:0051092; GO:0070102 0 0 0 PF00611;PF07714;PF00017; P47809 CHOYP_MP2K4.1.1 m.10635 sp MP2K4_MOUSE 69.516 351 95 5 54 392 39 389 6.98E-177 501 MP2K4_MOUSE reviewed Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) Map2k4 Jnkk1 Mek4 Mkk4 Prkmk4 Sek1 Serk1 Skk1 Mus musculus (Mouse) 397 activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; negative regulation of motor neuron apoptotic process [GO:2000672]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; response to wounding [GO:0009611] GO:0000165; GO:0004702; GO:0004713; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007254; GO:0007257; GO:0009611; GO:0034393; GO:0071260; GO:2000672 0 0 0 PF00069; Q19749 CHOYP_DLAT.1.1 m.64812 sp ODP2_CAEEL 56.36 456 175 7 62 508 67 507 6.98E-169 489 ODP2_CAEEL reviewed "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)" dlat-1 F23B12.5 Caenorhabditis elegans 507 glycolytic process [GO:0006096] GO:0004742; GO:0005759; GO:0006096; GO:0045254 0 0 0 PF00198;PF00364;PF02817; Q4ZJM9 CHOYP_contig_011969 m.13739 sp C1QL4_MOUSE 32.061 131 82 4 59 186 109 235 6.98E-10 59.7 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5I2E5 CHOYP_FCN2.2.2 m.36114 sp FCN2_BOVIN 51.049 143 63 3 3 145 160 295 6.98E-38 135 FCN2_BOVIN reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) 329 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0046872 0 0 0 PF01391;PF00147; Q5IS41 CHOYP_LOC100692883.1.1 m.5437 sp NCAN_PANTR 30.921 152 68 4 35 186 1095 1209 6.98E-17 82.8 NCAN_PANTR reviewed Neurocan core protein (Chondroitin sulfate proteoglycan 3) NCAN CSPG3 Pan troglodytes (Chimpanzee) 1321 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; Q5U3U0 CHOYP_LOC100640618.1.1 m.4378 sp PHYD1_DANRE 30.147 272 128 14 65 291 3 257 6.98E-11 65.5 PHYD1_DANRE reviewed Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC 1.-.-.-) phyhd1 zgc:101639 Danio rerio (Zebrafish) (Brachydanio rerio) 291 0 GO:0046872; GO:0051213 0 0 0 PF05721; Q6ZN84 CHOYP_LOC100373351.2.3 m.58893 sp CCD81_HUMAN 40.191 418 225 9 396 794 241 652 6.98E-76 262 CCD81_HUMAN reviewed Coiled-coil domain-containing protein 81 CCDC81 Homo sapiens (Human) 652 0 GO:0005737; GO:0005813 0 0 0 PF14908; Q8VBX0 CHOYP_LOC100378770.1.1 m.47941 sp ASB13_MOUSE 47.867 211 110 0 7 217 20 230 6.98E-58 189 ASB13_MOUSE reviewed Ankyrin repeat and SOCS box protein 13 (ASB-13) Asb13 Mus musculus (Mouse) 278 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q9BZE3 CHOYP_LOC100902125.1.1 m.22865 sp BARH1_HUMAN 72.043 93 25 1 143 234 174 266 6.98E-37 135 BARH1_HUMAN reviewed BarH-like 1 homeobox protein BARHL1 FKSG31 Homo sapiens (Human) 327 midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sensory perception of sound [GO:0007605] GO:0000977; GO:0001077; GO:0001228; GO:0001764; GO:0005634; GO:0006357; GO:0007605; GO:0030901; GO:0043524 0 0 0 PF00046; O14523 CHOYP_BRAFLDRAFT_118103.1.1 m.41767 sp C2C2L_HUMAN 25.97 593 349 20 46 601 4 543 6.99E-34 142 C2C2L_HUMAN reviewed C2 domain-containing protein 2-like (Transmembrane protein 24) C2CD2L KIAA0285 TMEM24 DLNB23 Homo sapiens (Human) 706 positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774] GO:0016021; GO:0035774 0 0 0 0 O32210 CHOYP_LOC100375758.1.1 m.41210 sp GR_BACSU 40.714 280 145 4 41 318 15 275 6.99E-61 198 GR_BACSU reviewed Glyoxal reductase (GR) (EC 1.1.1.-) (Methylglyoxal reductase) (EC 1.1.1.283) yvgN BSU33400 Bacillus subtilis (strain 168) 276 0 GO:0043892 0 0 cd06660; PF00248; P04755 CHOYP_LOC100533245.3.6 m.31982 sp ACH3_DROME 51 500 199 12 28 489 24 515 6.99E-153 449 ACH3_DROME reviewed Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) nAChRbeta1 Acr64B AcrD ard nAcRbeta-64B CG11348 Drosophila melanogaster (Fruit fly) 521 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P33015 CHOYP_LOC591506.1.1 m.58749 sp YEEE_ECOLI 20.87 345 227 10 70 401 5 316 6.99E-08 57.8 YEEE_ECOLI reviewed UPF0394 inner membrane protein YeeE yeeE b2013 JW1995 Escherichia coli (strain K12) 352 0 GO:0005886; GO:0016021 0 0 0 PF04143; P55866 CHOYP_BRAFLDRAFT_75631.1.1 m.40423 sp CASP3_XENLA 29.927 137 72 6 77 192 147 280 6.99E-08 54.7 CASP3_XENLA reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (xCPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] casp3 Xenopus laevis (African clawed frog) 282 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 P61222 CHOYP_PHUM_PHUM105900.1.1 m.19485 sp ABCE1_MOUSE 85.981 107 15 0 15 121 3 109 6.99E-61 199 ABCE1_MOUSE reviewed ATP-binding cassette sub-family E member 1 (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I) Abce1 Rli Mus musculus (Mouse) 599 ribosomal subunit export from nucleus [GO:0000054]; translational initiation [GO:0006413]; translational termination [GO:0006415] GO:0000054; GO:0005506; GO:0005524; GO:0005737; GO:0005739; GO:0006413; GO:0006415; GO:0016020; GO:0016887; GO:0043024 0 0 0 PF00005;PF00037;PF04068; Q15119 CHOYP_BRAFLDRAFT_114859.1.1 m.37271 sp PDK2_HUMAN 46.523 417 194 6 18 428 11 404 6.99E-132 389 PDK2_HUMAN reviewed "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)" PDK2 PDHK2 Homo sapiens (Human) 407 cellular response to nutrient [GO:0031670]; cellular response to reactive oxygen species [GO:0034614]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of cellular ketone metabolic process [GO:0010565]; regulation of gluconeogenesis [GO:0006111]; regulation of glucose metabolic process [GO:0010906]; regulation of pH [GO:0006885] GO:0004672; GO:0004740; GO:0005524; GO:0005654; GO:0005737; GO:0005739; GO:0005759; GO:0005967; GO:0006006; GO:0006111; GO:0006885; GO:0008286; GO:0010510; GO:0010565; GO:0010906; GO:0031670; GO:0034614; GO:0042593; GO:0042803; GO:0072332 0 0 0 PF10436;PF02518; Q30D77 CHOYP_CO1A1.1.1 m.32133 sp COOA1_MOUSE 38.895 869 358 23 252 1016 549 1348 6.99E-66 250 COOA1_MOUSE reviewed Collagen alpha-1(XXIV) chain Col24a1 Mus musculus (Mouse) 1733 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244; GO:0005201; GO:0005578; GO:0005581 0 0 0 PF01410;PF01391; Q8BZ20 CHOYP_CD36_83030.4.4 m.58369 sp PAR12_MOUSE 43.077 130 71 2 464 592 491 618 6.99E-22 105 PAR12_MOUSE reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) Parp12 Zc3hdc1 Mus musculus (Mouse) 711 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q96KG7 CHOYP_MEG11.2.25 m.13852 sp MEG10_HUMAN 36.877 602 338 27 2 592 246 816 6.99E-81 279 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q99M80 CHOYP_PTPRT.38.45 m.60044 sp PTPRT_MOUSE 32.342 538 322 13 405 903 754 1288 6.99E-62 233 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9QX47 CHOYP_SON.2.3 m.48056 sp SON_MOUSE 41.361 382 150 8 643 1010 2114 2435 6.99E-80 290 SON_MOUSE reviewed Protein SON (Negative regulatory element-binding protein) (NRE-binding protein) Son Nrebp Mus musculus (Mouse) 2444 "microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000226; GO:0000281; GO:0003677; GO:0003723; GO:0005654; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0016607; GO:0043066; GO:0043484; GO:0044822; GO:0048024; GO:0050733; GO:0051726; GO:0071011 0 0 0 PF01585; A1XBS5 CHOYP_LOC100879052.1.1 m.53743 sp F92A1_HUMAN 39.815 216 128 1 76 291 12 225 7.00E-50 172 F92A1_HUMAN reviewed Protein FAM92A1 FAM92A1 Homo sapiens (Human) 289 0 0 0 0 0 PF06730; O35806 CHOYP_contig_044236 m.51155 sp LTBP2_RAT 31.381 478 268 23 7 458 875 1318 7.00E-35 147 LTBP2_RAT reviewed Latent-transforming growth factor beta-binding protein 2 (LTBP-2) Ltbp2 Rattus norvegicus (Rat) 1764 transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005509; GO:0005576; GO:0007179; GO:0008201 0 0 0 PF00008;PF07645;PF12661;PF00683; P10394 CHOYP_contig_008633 m.10053 sp POL4_DROME 27.834 988 603 22 1 931 62 996 7.00E-109 367 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P23253 CHOYP_YJW5.1.1 m.2591 sp TCNA_TRYCR 23.759 282 165 10 2 265 683 932 7.00E-06 53.5 TCNA_TRYCR reviewed Sialidase (EC 3.2.1.18) (Major surface antigen) (Neuraminidase) (NA) TCNA Trypanosoma cruzi 1162 metabolic process [GO:0008152]; pathogenesis [GO:0009405] GO:0005886; GO:0008152; GO:0009405; GO:0031225; GO:0052794; GO:0052795; GO:0052796 0 0 0 PF13859; P34973 CHOYP_COX1.5.15 m.24407 sp DRD2B_XENLA 23.913 184 93 7 48 220 197 344 7.00E-06 49.3 DRD2B_XENLA reviewed D(2) dopamine receptor B (D2R-B) (D2R 2) (Fragment) drd2-b Xenopus laevis (African clawed frog) 345 adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195] GO:0004952; GO:0005887; GO:0007195 0 0 0 PF00001; P46825 CHOYP_KLC.1.3 m.15804 sp KLC_DORPE 85.484 124 18 0 1 124 21 144 7.00E-67 214 KLC_DORPE reviewed Kinesin light chain (KLC) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 571 0 GO:0003777; GO:0005737; GO:0005871; GO:0005874 0 0 0 PF13374; P53767 CHOYP_VGFR1.1.1 m.61201 sp VGFR1_RAT 30.703 1166 654 36 192 1287 83 1164 7.00E-145 481 VGFR1_RAT reviewed Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT) Flt1 Flt-1 Vegfr1 Rattus norvegicus (Rat) 1336 activation of MAPKK activity [GO:0000186]; aging [GO:0007568]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; cell migration [GO:0016477]; cellular response to hypoxia [GO:0071456]; chemotaxis [GO:0006935]; embryonic morphogenesis [GO:0048598]; female pregnancy [GO:0007565]; intracellular receptor signaling pathway [GO:0030522]; liver regeneration [GO:0097421]; negative regulation of sprouting angiogenesis [GO:1903671]; negative regulation of vascular endothelial growth factor production [GO:1904046]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of smooth muscle contraction [GO:0006940]; response to activity [GO:0014823]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000186; GO:0001525; GO:0001666; GO:0004714; GO:0004716; GO:0005021; GO:0005524; GO:0005615; GO:0005768; GO:0005886; GO:0005887; GO:0006468; GO:0006935; GO:0006940; GO:0007169; GO:0007565; GO:0007568; GO:0008284; GO:0014823; GO:0016477; GO:0018108; GO:0019838; GO:0030335; GO:0030522; GO:0032355; GO:0045471; GO:0046777; GO:0048010; GO:0048514; GO:0048598; GO:0048661; GO:0060252; GO:0071456; GO:0097421; GO:1903671; GO:1904046 0 0 0 PF07679;PF07714; Q3UIR3 CHOYP_LOC100555386.3.3 m.53417 sp DTX3L_MOUSE 52.941 187 80 4 423 608 568 747 7.00E-56 204 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q62627 CHOYP_LOC100649375.1.1 m.21222 sp PAWR_RAT 35.789 95 52 2 316 403 239 331 7.00E-09 60.5 PAWR_RAT reviewed PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) (Transcriptional repressor Par-4-like protein PAWR) Pawr Par4 Rattus norvegicus (Rat) 332 "actin filament bundle assembly [GO:0051017]; activation of cysteine-type endopeptidase activity [GO:0097202]; apoptotic process [GO:0006915]; calcium ion import into cell [GO:1990035]; cellular response to estradiol stimulus [GO:0071392]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to interleukin-1 [GO:0071347]; cellular response to vitamin E [GO:0071306]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; negative regulation of calcium ion import [GO:0090281]; positive regulation of action potential [GO:0045760]; positive regulation of apoptotic process [GO:0043065]; positive regulation of hindgut contraction [GO:0060450]; positive regulation of leukocyte tethering or rolling [GO:1903238]; positive regulation of neuronal action potential [GO:1904457]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of relaxation of smooth muscle [GO:1901082]; regulation of transcription, DNA-templated [GO:0006355]; response to estradiol [GO:0032355]; response to iron(II) ion [GO:0010040]; response to lipopolysaccharide [GO:0032496]; response to wounding [GO:0009611]; transcription, DNA-templated [GO:0006351]" GO:0003779; GO:0005080; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0006915; GO:0008157; GO:0009611; GO:0010040; GO:0030424; GO:0032355; GO:0032496; GO:0032516; GO:0043005; GO:0043025; GO:0043065; GO:0043525; GO:0045760; GO:0050965; GO:0050966; GO:0051017; GO:0060450; GO:0071306; GO:0071347; GO:0071372; GO:0071392; GO:0090281; GO:0097202; GO:1901082; GO:1903238; GO:1904457; GO:1990035; GO:2000391 0 0 0 0 Q6GV29 CHOYP_LOC100376892.1.1 m.18411 sp B3GNL_RAT 57.602 342 144 1 4 344 16 357 7.00E-152 434 B3GNL_RAT reviewed "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 (BGnT-like protein 1) (Beta1,3-N-acetylglucosaminyltransferase-like protein 1) (Beta3Gn-T-like protein 1) (Beta3GnTL1) (EC 2.4.1.-)" B3gntl1 Rattus norvegicus (Rat) 357 0 GO:0016757 0 0 0 PF00535; Q8BP56 CHOYP_BRAFLDRAFT_261940.1.2 m.5236 sp ATHL1_MOUSE 38.308 650 380 8 81 716 9 651 7.00E-148 452 ATHL1_MOUSE reviewed Acid trehalase-like protein 1 (EC 3.2.1.-) Athl1 Mus musculus (Mouse) 690 carbohydrate metabolic process [GO:0005975] GO:0005618; GO:0005975; GO:0016787; GO:0016798 0 0 0 PF03632; Q96WM9 CHOYP_LOC100206475.11.16 m.49485 sp LAC2_BOTFU 34.263 251 138 5 99 332 73 313 7.00E-29 120 LAC2_BOTFU reviewed Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Urishiol oxidase 2) lcc2 Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) 581 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q9HC36 CHOYP_LOC100745956.1.1 m.49099 sp MRM3_HUMAN 33.158 190 107 7 69 249 96 274 7.00E-21 96.7 MRM3_HUMAN reviewed "rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)" MRM3 RNMTL1 HC90 Homo sapiens (Human) 420 RNA methylation [GO:0001510]; rRNA processing [GO:0006364] GO:0001510; GO:0003723; GO:0005739; GO:0006364; GO:0008168; GO:0008173; GO:0044822 0 0 0 PF00588; A4IF63 CHOYP_BRAFLDRAFT_69647.2.5 m.21110 sp TRIM2_BOVIN 25.62 242 145 9 36 260 119 342 7.01E-07 55.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_205965.15.43 m.38246 sp TRIM3_HUMAN 28.8 125 84 3 162 284 622 743 7.01E-09 61.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P00787 CHOYP_NEMVEDRAFT_V1G191860.1.1 m.41326 sp CATB_RAT 62.037 216 79 3 1 214 117 331 7.01E-93 278 CATB_RAT reviewed Cathepsin B (EC 3.4.22.1) (Cathepsin B1) (RSG-2) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] Ctsb Rattus norvegicus (Rat) 339 autophagy [GO:0006914]; cellular response to mechanical stimulus [GO:0071260]; negative regulation of cell death [GO:0060548]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of catalytic activity [GO:0050790]; response to amine [GO:0014075]; response to cytokine [GO:0034097]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to interleukin-4 [GO:0070670]; response to mechanical stimulus [GO:0009612]; response to organic cyclic compound [GO:0014070]; response to peptide hormone [GO:0043434]; response to wounding [GO:0009611]; skeletal muscle tissue development [GO:0007519]; spermatogenesis [GO:0007283] GO:0004175; GO:0004197; GO:0005576; GO:0005615; GO:0005737; GO:0005739; GO:0005764; GO:0006508; GO:0006914; GO:0007283; GO:0007519; GO:0009611; GO:0009612; GO:0009749; GO:0009897; GO:0009986; GO:0014070; GO:0014075; GO:0016324; GO:0030984; GO:0032403; GO:0034097; GO:0042277; GO:0042383; GO:0042470; GO:0043434; GO:0043621; GO:0045471; GO:0050790; GO:0051603; GO:0060548; GO:0070670; GO:0071260 0 0 0 PF00112;PF08127; P35590 CHOYP_LOC100184792.3.3 m.58440 sp TIE1_HUMAN 34.507 142 75 6 176 305 210 345 7.01E-18 88.2 TIE1_HUMAN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE Homo sapiens (Human) 1138 angiogenesis [GO:0001525]; in utero embryonic development [GO:0001701]; mesoderm development [GO:0007498]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; plasma membrane fusion [GO:0045026]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570] GO:0001525; GO:0001570; GO:0001701; GO:0004714; GO:0005524; GO:0005887; GO:0007165; GO:0007498; GO:0016525; GO:0030336; GO:0032526; GO:0045026 0 0 0 PF00041;PF00047;PF07714; P42575 CHOYP_CASP2.1.5 m.15170 sp CASP2_HUMAN 41.806 299 153 5 357 638 154 448 7.01E-64 221 CASP2_HUMAN reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 NEDD2 Homo sapiens (Human) 452 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aging [GO:0007568]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]; regulation of apoptotic process [GO:0042981]" GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0006919; GO:0006977; GO:0007420; GO:0007568; GO:0008630; GO:0016020; GO:0016485; GO:0019899; GO:0019904; GO:0035234; GO:0042981; GO:0043065; GO:0043525; GO:0071260; GO:0097153; GO:0097190; GO:0097192; GO:0097194; GO:2001235 0 0 0 PF00619; P51693 CHOYP_LOC100201890.1.1 m.22311 sp APLP1_HUMAN 24.717 619 349 15 1 558 84 646 7.01E-50 185 APLP1_HUMAN reviewed Amyloid-like protein 1 (APLP) (APLP-1) [Cleaved into: C30] APLP1 Homo sapiens (Human) 650 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cellular response to norepinephrine stimulus [GO:0071874]; endocytosis [GO:0006897]; negative regulation of cAMP biosynthetic process [GO:0030818]; nervous system development [GO:0007399]; organ morphogenesis [GO:0009887] GO:0005604; GO:0005886; GO:0006897; GO:0006915; GO:0007155; GO:0007193; GO:0007399; GO:0008201; GO:0009887; GO:0016021; GO:0030818; GO:0031694; GO:0031695; GO:0031696; GO:0042802; GO:0046914; GO:0048471; GO:0071874 0 0 0 PF10515;PF12924;PF12925;PF02177; Q00IB7 CHOYP_LOC100369093.1.1 m.36203 sp PKHH1_DANRE 28.448 116 77 3 2 116 622 732 7.01E-09 56.2 PKHH1_DANRE reviewed Pleckstrin homology domain-containing family H member 1 (PH domain-containing family H member 1) (Protein max-1 homolog) plekhh1 max1 Danio rerio (Zebrafish) (Brachydanio rerio) 1433 blood vessel morphogenesis [GO:0048514]; patterning of blood vessels [GO:0001569] GO:0001569; GO:0005856; GO:0048514 0 0 0 PF00373;PF00784;PF00169; Q2HJC9 CHOYP_TSP_00320.1.1 m.7280 sp PQBP1_BOVIN 42.857 210 75 5 141 309 48 253 7.01E-38 138 PQBP1_BOVIN reviewed Polyglutamine-binding protein 1 (PQBP-1) (Polyglutamine tract-binding protein 1) PQBP1 Bos taurus (Bovine) 263 "alternative mRNA splicing, via spliceosome [GO:0000380]; neuron projection development [GO:0031175]; regulation of dendrite morphogenesis [GO:0048814]; regulation of RNA splicing [GO:0043484]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000380; GO:0006351; GO:0006355; GO:0010494; GO:0016607; GO:0031175; GO:0043021; GO:0043484; GO:0048814; GO:0071598 0 0 0 0 Q2KI00 CHOYP_LOC100165703.1.1 m.48642 sp F107B_BOVIN 34.259 108 66 2 144 249 14 118 7.01E-07 50.8 F107B_BOVIN reviewed Protein FAM107B FAM107B Bos taurus (Bovine) 131 0 0 0 0 0 PF06625; Q61187 CHOYP_TSG101.1.1 m.66808 sp TS101_MOUSE 53.371 178 71 2 1 178 1 166 7.01E-64 207 TS101_MOUSE reviewed Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Tsg101 Mus musculus (Mouse) 391 "cell cycle arrest [GO:0007050]; cell differentiation [GO:0030154]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; keratinocyte differentiation [GO:0030216]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein monoubiquitination [GO:0006513]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]" GO:0000813; GO:0001558; GO:0003714; GO:0005634; GO:0005730; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0006513; GO:0007050; GO:0008285; GO:0008333; GO:0015031; GO:0030154; GO:0030216; GO:0030374; GO:0031625; GO:0031902; GO:0042803; GO:0043130; GO:0043162; GO:0043405; GO:0045892; GO:0046755; GO:0046790; GO:0048306; GO:0048524; GO:0051301; GO:0070062; GO:1902188; GO:1903543; GO:1903551; GO:1903772; GO:1903774; GO:1990182; GO:2000397 0 0 0 PF05743;PF09454; Q6PDJ1 CHOYP_NEMVEDRAFT_V1G239644.1.4 m.1070 sp CAHD1_MOUSE 27.735 1042 665 37 44 1020 59 1077 7.01E-93 327 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q7L0X2 CHOYP_NEMVEDRAFT_V1G246977.1.1 m.36583 sp ERIP6_HUMAN 31.651 436 242 11 232 656 238 628 7.01E-52 194 ERIP6_HUMAN reviewed Glutamate-rich protein 6 (Protein FAM194A) ERICH6 C3orf44 FAM194A Homo sapiens (Human) 663 0 0 0 0 0 PF14977; Q8CGZ0 CHOYP_CHERP.1.1 m.22401 sp CHERP_MOUSE 44.382 356 168 4 1 354 1 328 7.01E-85 294 CHERP_MOUSE reviewed Calcium homeostasis endoplasmic reticulum protein (SR-related CTD-associated factor 6) Cherp Scaf6 Mus musculus (Mouse) 936 cellular calcium ion homeostasis [GO:0006874]; negative regulation of cell proliferation [GO:0008285]; positive regulation of NFAT protein import into nucleus [GO:0051533]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396] GO:0005737; GO:0005783; GO:0006396; GO:0006874; GO:0008285; GO:0016020; GO:0044325; GO:0044822; GO:0048471; GO:0051209; GO:0051533 0 0 0 PF04818;PF01585;PF01805; Q9IBG7 CHOYP_LOC100186692.1.1 m.7600 sp KCP_XENLA 35.641 390 217 11 1877 2250 1167 1538 7.01E-48 193 KCP_XENLA reviewed Kielin/chordin-like protein (Cysteine-rich motor neuron 2 protein) (CRIM-2) (Kielin) kcp crim2 Xenopus laevis (African clawed frog) 2327 0 GO:0005576 0 0 0 PF00093;PF00094; Q9R0X0 CHOYP_DHX57.2.2 m.45703 sp MED20_MOUSE 43.925 214 112 2 1 213 1 207 7.01E-62 195 MED20_MOUSE reviewed Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) Med20 Trfp Mus musculus (Mouse) 212 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; skeletal muscle cell differentiation [GO:0035914]; transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0003713; GO:0005654; GO:0006351; GO:0006357; GO:0016592; GO:0035914 0 0 0 PF08612; Q9ULJ7 CHOYP_LOC581927.17.27 m.46534 sp ANR50_HUMAN 31.72 558 354 20 3 536 535 1089 7.01E-49 185 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9Z306 CHOYP_S22A4.1.1 m.11876 sp S22A4_MOUSE 27.726 541 338 9 6 514 3 522 7.01E-63 218 S22A4_MOUSE reviewed Solute carrier family 22 member 4 (Organic cation/carnitine transporter 1) Slc22a4 Octn1 Mus musculus (Mouse) 553 carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; quaternary ammonium group transport [GO:0015697]; sodium ion transport [GO:0006814]; triglyceride metabolic process [GO:0006641] GO:0005524; GO:0005739; GO:0005887; GO:0006641; GO:0006814; GO:0009437; GO:0015226; GO:0015293; GO:0015491; GO:0015651; GO:0015697; GO:0015879; GO:0016324; GO:0030165 0 0 cd06174; PF00083; H9TB18 CHOYP_LOC100714172.1.1 m.2013 sp AOXD_CAVPO 60.993 141 54 1 5 144 1 141 7.02E-53 182 AOXD_CAVPO reviewed Aldehyde oxidase 4 (EC 1.2.3.1) (Aldehyde oxidase homolog 2) (Azaheterocycle hydroxylase 4) (EC 1.17.3.-) (Retinal oxidase) AOX4 Cavia porcellus (Guinea pig) 1341 0 GO:0004031; GO:0005506; GO:0005737; GO:0009055; GO:0016614; GO:0050660; GO:0051287; GO:0051537 0 0 cd00207; PF01315;PF02738;PF03450;PF00941;PF00111;PF01799; O75095 CHOYP_LOC763793.3.7 m.24306 sp MEGF6_HUMAN 35.309 405 242 13 4 404 585 973 7.02E-50 184 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P0CB05 CHOYP_LOC100368223.1.1 m.9825 sp CEP63_CHICK 34.961 512 296 12 71 574 3 485 7.02E-68 241 CEP63_CHICK reviewed Centrosomal protein of 63 kDa (Cep63) CEP63 Gallus gallus (Chicken) 711 cell division [GO:0051301]; centriole replication [GO:0007099]; de novo centriole assembly [GO:0098535]; DNA damage checkpoint [GO:0000077]; mitotic nuclear division [GO:0007067]; signal transduction in response to DNA damage [GO:0042770]; spindle assembly [GO:0051225] GO:0000077; GO:0000922; GO:0005813; GO:0005814; GO:0007067; GO:0007099; GO:0042770; GO:0051225; GO:0051301; GO:0098535 0 0 0 PF17045; P55210 CHOYP_CASP7.1.23 m.2521 sp CASP7_HUMAN 30.469 256 139 10 12 247 67 303 7.02E-24 100 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P62246 CHOYP_LOC100206814.1.1 m.23080 sp RS15A_RAT 82.308 130 23 0 13 142 1 130 7.02E-78 229 RS15A_RAT reviewed 40S ribosomal protein S15a Rps15a Rattus norvegicus (Rat) 130 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00410; Q2NL27 CHOYP_LOC660898.1.1 m.38632 sp RT23_BOVIN 40.741 81 33 5 7 77 29 104 7.02E-07 50.4 RT23_BOVIN reviewed "28S ribosomal protein S23, mitochondrial (MRP-S23) (S23mt)" MRPS23 Bos taurus (Bovine) 190 mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005763; GO:0032543; GO:0070124; GO:0070125 0 0 0 PF10484; Q54KA7 CHOYP_LOC755512.4.5 m.33017 sp SECG_DICDI 34.413 247 142 4 5 233 280 524 7.02E-32 127 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q5G268 CHOYP_LOC757271.2.2 m.50609 sp NETR_NOMLE 50.459 109 53 1 47 155 274 381 7.02E-29 114 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q6PHN1 CHOYP_LOC100368744.1.1 m.7781 sp CCD57_MOUSE 35.337 832 468 12 9 823 12 790 7.02E-119 393 CCD57_MOUSE reviewed Coiled-coil domain-containing protein 57 Ccdc57 Mus musculus (Mouse) 1016 0 0 0 0 0 0 Q8TEW0 CHOYP_LOC100371218.2.3 m.38221 sp PARD3_HUMAN 39.919 739 351 21 3 703 1 684 7.02E-126 429 PARD3_HUMAN reviewed Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) PARD3 PAR3 PAR3A Homo sapiens (Human) 1356 asymmetric cell division [GO:0008356]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell cycle [GO:0007049]; establishment of epithelial cell polarity [GO:0090162]; establishment or maintenance of cell polarity [GO:0007163]; myelination in peripheral nervous system [GO:0022011]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of myelination [GO:0031643]; protein complex assembly [GO:0006461]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; protein targeting to membrane [GO:0006612]; regulation of cellular localization [GO:0060341]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005546; GO:0005547; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005923; GO:0005938; GO:0006461; GO:0006612; GO:0007049; GO:0007163; GO:0007179; GO:0007205; GO:0007409; GO:0008356; GO:0010801; GO:0012505; GO:0022011; GO:0030054; GO:0031643; GO:0032266; GO:0033269; GO:0043025; GO:0043234; GO:0044295; GO:0060341; GO:0070830; GO:0090162 0 0 0 PF12053;PF00595; Q949X7 CHOYP_SELMODRAFT_182543.1.1 m.33319 sp DCDA1_ARATH 42.723 213 117 4 44 254 67 276 7.02E-47 166 DCDA1_ARATH reviewed "Diaminopimelate decarboxylase 1, chloroplastic (DAP decarboxylase 1) (DAPDC 1) (EC 4.1.1.20)" LYSA1 At3g14390 MLN21.17 Arabidopsis thaliana (Mouse-ear cress) 484 lysine biosynthetic process via diaminopimelate [GO:0009089] GO:0008836; GO:0009089; GO:0009570 "PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1." 0 cd06828; PF02784;PF00278; Q96PN7 CHOYP_LOC100889942.1.1 m.57041 sp TREF1_HUMAN 33.261 460 270 15 1244 1693 676 1108 7.02E-53 207 TREF1_HUMAN reviewed Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) TRERF1 BCAR2 RAPA TREP132 Homo sapiens (Human) 1200 "cholesterol catabolic process [GO:0006707]; homeostatic process [GO:0042592]; multicellular organism development [GO:0007275]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of hormone biosynthetic process [GO:0046885]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; steroid biosynthetic process [GO:0006694]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0001104; GO:0003700; GO:0005634; GO:0005667; GO:0006351; GO:0006357; GO:0006694; GO:0006707; GO:0007275; GO:0008134; GO:0008301; GO:0030374; GO:0042592; GO:0044212; GO:0045893; GO:0046872; GO:0046885 0 0 0 PF01448;PF13912; A2RRT3 CHOYP_LOC100377168.1.3 m.14316 sp FB31A_XENLA 29.373 303 169 10 1 286 83 357 7.03E-27 113 FB31A_XENLA reviewed F-box only protein 31-A fbxo31-a fbxo31 Xenopus laevis (African clawed frog) 519 cellular response to DNA damage stimulus [GO:0006974]; mitotic G1 DNA damage checkpoint [GO:0031571]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0006974; GO:0008054; GO:0016567; GO:0019005; GO:0031146; GO:0031571 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; O61462 CHOYP_RS6.8.12 m.36342 sp RL37A_CRYST 86.207 87 12 0 102 188 3 89 7.03E-50 159 RL37A_CRYST reviewed 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) 92 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046872 0 0 0 PF01780; P11833 CHOYP_contig_015657 m.18311 sp TBB_PARLI 96.196 184 7 0 24 207 24 207 7.03E-121 355 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P22897 CHOYP_LOC576927.2.4 m.2382 sp MRC1_HUMAN 22.934 593 382 24 32 585 802 1358 7.03E-24 110 MRC1_HUMAN reviewed Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) MRC1 CLEC13D CLEC13DL MRC1L1 Homo sapiens (Human) 1456 cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-4 [GO:0071353]; cellular response to lipopolysaccharide [GO:0071222]; receptor-mediated endocytosis [GO:0006898] GO:0001618; GO:0004872; GO:0004888; GO:0005537; GO:0005886; GO:0005887; GO:0006898; GO:0009986; GO:0010008; GO:0071222; GO:0071346; GO:0071353 0 0 cd00062; PF00040;PF00059;PF00652; P23785 CHOYP_BRAFLDRAFT_102424.3.6 m.21523 sp GRN_RAT 40.727 523 275 12 30 545 89 583 7.03E-109 342 GRN_RAT reviewed Granulins [Cleaved into: Acrogranin (Progranulin); Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] Grn Rattus norvegicus (Rat) 588 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of neuron projection development [GO:0010976]; response to estradiol [GO:0032355]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0005623; GO:0010976; GO:0032355; GO:0035988; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351 0 0 0 PF00396; P49230 CHOYP_PROF2.1.1 m.52866 sp PROF_ENTHI 34 100 65 1 42 140 22 121 7.03E-11 59.3 PROF_ENTHI reviewed Profilin 0 Entamoeba histolytica 130 0 GO:0005737; GO:0005856 0 0 0 PF00235; Q6NSJ0 CHOYP_LOC100376224.1.1 m.10954 sp K1161_HUMAN 33.254 421 268 5 2 417 299 711 7.03E-81 266 K1161_HUMAN reviewed Uncharacterized family 31 glucosidase KIAA1161 (EC 3.2.1.-) KIAA1161 Homo sapiens (Human) 714 carbohydrate metabolic process [GO:0005975]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of protein kinase B signaling [GO:0051897]; skeletal muscle fiber development [GO:0048741] GO:0004553; GO:0005975; GO:0016021; GO:0031965; GO:0043568; GO:0048741; GO:0051897 0 0 0 PF01055; Q8T773 CHOYP_LOC100366482.1.1 m.9777 sp MDH1B_BRAFL 46.996 466 245 2 27 492 1 464 7.03E-161 471 MDH1B_BRAFL reviewed Putative malate dehydrogenase 1B (EC 1.1.1.-) MDH1B Branchiostoma floridae (Florida lancelet) (Amphioxus) 522 carbohydrate metabolic process [GO:0005975]; cell redox homeostasis [GO:0045454]; malate metabolic process [GO:0006108]; tricarboxylic acid cycle [GO:0006099] GO:0005623; GO:0005975; GO:0006099; GO:0006108; GO:0009055; GO:0015035; GO:0016615; GO:0016616; GO:0045454 0 0 0 PF02866;PF00056; Q967R6 CHOYP_CPEB.2.2 m.19533 sp CPEB_APLCA 60.192 417 134 3 28 428 284 684 7.03E-177 513 CPEB_APLCA reviewed Cytoplasmic polyadenylation element-binding protein (CPE-binding protein) (CPEB) 0 Aplysia californica (California sea hare) 687 positive regulation of translation [GO:0045727]; regulation of protein localization [GO:0032880]; regulation of synaptic plasticity [GO:0048167] GO:0000166; GO:0003729; GO:0008494; GO:0032880; GO:0043005; GO:0045727; GO:0048167; GO:0071598 0 0 0 PF16368;PF16366;PF16367; Q96MM6 CHOYP_LOC100207121.7.9 m.59915 sp HS12B_HUMAN 35.071 633 341 15 23 594 61 684 7.03E-116 363 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q96RW7 CHOYP_HMCN1.1.44 m.1853 sp HMCN1_HUMAN 26.016 246 145 9 28 264 2299 2516 7.03E-13 73.6 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9H0J9 CHOYP_BRAFLDRAFT_92020.3.3 m.65290 sp PAR12_HUMAN 28.148 675 372 25 124 759 89 689 7.03E-64 232 PAR12_HUMAN reviewed Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1) PARP12 ZC3HDC1 Homo sapiens (Human) 701 0 GO:0003950; GO:0005634; GO:0044822; GO:0046872 0 0 0 PF00644;PF02825;PF00642; Q9VAC5 CHOYP_DWIL_GK13920.1.1 m.17794 sp ADA17_DROME 37.161 479 270 12 12 469 20 488 7.03E-93 300 ADA17_DROME reviewed ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) 732 membrane protein ectodomain proteolysis [GO:0006509] GO:0004222; GO:0006509; GO:0008270; GO:0016021 0 0 0 PF16698;PF00200;PF01562; A4IF63 CHOYP_BRAFLDRAFT_87269.5.8 m.39550 sp TRIM2_BOVIN 25.123 203 144 6 349 546 545 744 7.04E-12 72 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43312 CHOYP_MTSS1.4.5 m.58127 sp MTSS1_HUMAN 60.534 337 121 4 1 332 1 330 7.04E-122 390 MTSS1_HUMAN reviewed Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) 755 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; movement of cell or subcellular component [GO:0006928]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of defense response to virus by host [GO:0002230]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; xenophagy [GO:0098792] GO:0001726; GO:0002230; GO:0003785; GO:0005102; GO:0005737; GO:0006928; GO:0007009; GO:0007155; GO:0007169; GO:0015629; GO:0030035; GO:0030036; GO:0030139; GO:0042802; GO:0050680; GO:0061333; GO:0071498; GO:0072102; GO:0072160; GO:0098792; GO:2001013 0 0 0 PF08397;PF02205; O70277 CHOYP_BRAFLDRAFT_109861.2.2 m.42024 sp TRIM3_RAT 25.373 134 90 3 20 147 614 743 7.04E-08 53.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P46088 CHOYP_GST.1.1 m.29566 sp GST_NOTSL 37.321 209 125 2 1 209 1 203 7.04E-39 135 GST_NOTSL reviewed Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma) 0 Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei) 203 0 GO:0004364; GO:0005737 0 0 0 PF14497;PF02798; Q0P4F7 CHOYP_ACSF2.3.4 m.43344 sp ACSF2_DANRE 27.288 590 342 19 5 543 53 606 7.04E-48 179 ACSF2_DANRE reviewed "Acyl-CoA synthetase family member 2, mitochondrial (EC 6.2.1.-)" acsf2 zgc:152887 Danio rerio (Zebrafish) (Brachydanio rerio) 606 fatty acid metabolic process [GO:0006631] GO:0005524; GO:0005739; GO:0006631; GO:0016874 0 0 0 PF00501;PF13193; Q2TBR7 CHOYP_CENPS.1.1 m.49223 sp CENPS_BOVIN 55.294 85 38 0 51 135 17 101 7.04E-28 104 CENPS_BOVIN reviewed Centromere protein S (CENP-S) (Apoptosis-inducing TAF9-like domain-containing protein 1 homolog) (FANCM-interacting histone fold protein 1) APITD1 CENPS FAAP16 MHF1 Bos taurus (Bovine) 138 cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; kinetochore assembly [GO:0051382]; mitotic nuclear division [GO:0007067]; mitotic recombination [GO:0006312]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712] GO:0000712; GO:0000777; GO:0003677; GO:0003682; GO:0003690; GO:0006281; GO:0006312; GO:0006974; GO:0007067; GO:0031297; GO:0036297; GO:0043240; GO:0051301; GO:0051382; GO:0071821 0 0 0 PF15630; Q6Q899 CHOYP_IFIH1.4.14 m.40815 sp DDX58_MOUSE 28.947 494 288 18 135 588 14 484 7.04E-45 174 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q6ZPS2 CHOYP_CP2CN.1.1 m.20211 sp CRNS1_MOUSE 51.923 260 123 1 23 282 452 709 7.04E-84 274 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q80YR7 CHOYP_CLSPN.1.1 m.13779 sp CLSPN_MOUSE 34.953 535 279 17 838 1336 812 1313 7.04E-59 226 CLSPN_MOUSE reviewed Claspin Clspn Mus musculus (Mouse) 1315 activation of protein kinase activity [GO:0032147]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; DNA replication checkpoint [GO:0000076]; G2 DNA damage checkpoint [GO:0031572]; mitotic DNA replication checkpoint [GO:0033314]; peptidyl-serine phosphorylation [GO:0018105] GO:0000076; GO:0000077; GO:0000217; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0006281; GO:0010997; GO:0018105; GO:0031572; GO:0032147; GO:0033314 0 0 0 0 Q8IYS1 CHOYP_P20D2.1.2 m.9006 sp P20D2_HUMAN 45.61 410 207 6 1 396 20 427 7.04E-122 362 P20D2_HUMAN reviewed Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) PM20D2 ACY1L2 Homo sapiens (Human) 436 proteolysis [GO:0006508]; regulation of cellular protein metabolic process [GO:0032268] GO:0005654; GO:0006508; GO:0016805; GO:0032268; GO:0070062 0 0 0 PF07687;PF01546; Q8R066 CHOYP_C1QT4.2.5 m.28767 sp C1QT4_MOUSE 27.586 319 192 10 53 346 22 326 7.04E-18 87.8 C1QT4_MOUSE reviewed Complement C1q tumor necrosis factor-related protein 4 C1qtnf4 Mus musculus (Mouse) 326 0 GO:0005615 0 0 0 PF00386; Q93T20 CHOYP_TRIADDRAFT_64314.1.2 m.9124 sp CHRR_PSEPU 31.667 180 105 6 8 182 7 173 7.04E-16 75.5 CHRR_PSEPU reviewed Chromate reductase (CHRR) (EC 1.6.5.2) (NAD(P)H dehydrogenase (quinone)) chrR Pseudomonas putida (Arthrobacter siderocapsulatus) 186 0 GO:0003955 0 0 0 PF03358; Q9BST9 CHOYP_LOC581809.1.2 m.7729 sp RTKN_HUMAN 37.875 433 239 10 171 579 37 463 7.04E-86 281 RTKN_HUMAN reviewed Rhotekin RTKN RTKN1 Homo sapiens (Human) 563 apoptotic process [GO:0006915]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165] GO:0005095; GO:0005525; GO:0005829; GO:0006915; GO:0007165; GO:0007266; GO:0017049 0 0 0 PF08174;PF00169; Q9DFQ7 CHOYP_RL24.9.9 m.57775 sp RL24_GILMI 77.876 113 25 0 1 113 1 113 7.04E-63 191 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9ERZ8 CHOYP_TRPV3.2.3 m.62872 sp TRPV4_RAT 22.131 610 348 20 99 673 211 728 7.04E-22 105 TRPV4_RAT reviewed Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) Trpv4 Vroac Rattus norvegicus (Rat) 871 actin cytoskeleton reorganization [GO:0031532]; actin filament organization [GO:0007015]; blood vessel endothelial cell delamination [GO:0097497]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; cell-cell junction assembly [GO:0007043]; cellular calcium ion homeostasis [GO:0006874]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to heat [GO:0034605]; cellular response to osmotic stress [GO:0071470]; cortical microtubule organization [GO:0043622]; diet induced thermogenesis [GO:0002024]; glucose homeostasis [GO:0042593]; hyperosmotic salinity response [GO:0042538]; hypotonic response [GO:0006971]; microtubule polymerization [GO:0046785]; multicellular organismal water homeostasis [GO:0050891]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osmosensory signaling pathway [GO:0007231]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of energy homeostasis [GO:2000507]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of vascular permeability [GO:0043117]; response to insulin [GO:0032868]; signal transduction involved in regulation of aerobic respiration [GO:1903759]; vasopressin secretion [GO:0030103] GO:0000122; GO:0002024; GO:0003779; GO:0005034; GO:0005080; GO:0005261; GO:0005262; GO:0005516; GO:0005524; GO:0005829; GO:0005886; GO:0005887; GO:0005912; GO:0005925; GO:0005929; GO:0006874; GO:0006971; GO:0007015; GO:0007043; GO:0007204; GO:0007231; GO:0008017; GO:0009986; GO:0010628; GO:0010759; GO:0010977; GO:0015275; GO:0016324; GO:0030027; GO:0030103; GO:0030175; GO:0030426; GO:0030864; GO:0031117; GO:0031410; GO:0031532; GO:0032587; GO:0032868; GO:0034605; GO:0042538; GO:0042593; GO:0043014; GO:0043117; GO:0043622; GO:0046330; GO:0046785; GO:0048487; GO:0050729; GO:0050891; GO:0051015; GO:0070374; GO:0070509; GO:0070588; GO:0071470; GO:0071476; GO:0071477; GO:0071639; GO:0071642; GO:0071651; GO:0097497; GO:1903444; GO:1903759; GO:2000340; GO:2000507; GO:2000778 0 0 0 PF12796;PF00520; Q9HCU4 CHOYP_CELR2.8.8 m.56899 sp CELR2_HUMAN 28.81 538 331 18 30 530 180 702 7.04E-41 166 CELR2_HUMAN reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) 2923 "dendrite morphogenesis [GO:0048813]; G-protein coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0007186; GO:0007283; GO:0016021; GO:0016055; GO:0021999; GO:0022407; GO:0048813; GO:0060071 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF12661;PF00053;PF02210; Q9QYX7 CHOYP_PCLO.1.2 m.27122 sp PCLO_MOUSE 32.979 470 174 16 879 1338 4418 4756 7.04E-50 199 PCLO_MOUSE reviewed Protein piccolo (Aczonin) (Brain-derived HLMN protein) (Multidomain presynaptic cytomatrix protein) Pclo Acz Mus musculus (Mouse) 5068 cAMP-mediated signaling [GO:0019933]; cytoskeleton organization [GO:0007010]; insulin secretion [GO:0030073]; protein localization to synapse [GO:0035418]; regulation of exocytosis [GO:0017157]; synapse assembly [GO:0007416]; synaptic vesicle targeting [GO:0016080] GO:0005509; GO:0005522; GO:0005544; GO:0007010; GO:0007416; GO:0014069; GO:0016080; GO:0017157; GO:0019933; GO:0030054; GO:0030073; GO:0035418; GO:0045202; GO:0048786; GO:0070062 0 0 0 PF00168;PF00595;PF05715; Q9R1R2 CHOYP_BRAFLDRAFT_109857.3.15 m.13226 sp TRIM3_MOUSE 27.193 228 140 11 56 275 506 715 7.04E-10 62.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A0JM98 CHOYP_LOC578673.1.1 m.6957 sp TDRD5_XENTR 25.217 345 227 6 417 733 382 723 7.05E-28 125 TDRD5_XENTR reviewed Tudor domain-containing protein 5 tdrd5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 963 DNA methylation involved in gamete generation [GO:0043046]; P granule organization [GO:0030719]; spermatid development [GO:0007286] GO:0007286; GO:0030719; GO:0033391; GO:0043046; GO:0071546 0 0 0 PF12872;PF00567; A2AAJ9 CHOYP_TITIN.1.19 m.2118 sp OBSCN_MOUSE 32.8 125 79 2 17 138 89 211 7.05E-13 75.1 OBSCN_MOUSE reviewed Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Obscn Gm878 Mus musculus (Mouse) 8891 cell differentiation [GO:0030154]; mitophagy in response to mitochondrial depolarization [GO:0098779]; multicellular organism development [GO:0007275]; regulation of Rho protein signal transduction [GO:0035023] GO:0004674; GO:0005089; GO:0005524; GO:0005863; GO:0007275; GO:0030018; GO:0030154; GO:0030506; GO:0031430; GO:0031432; GO:0035023; GO:0098779 0 0 0 PF00041;PF07679;PF00612;PF00069;PF00621; O05972 CHOYP_LOC574855.6.9 m.46549 sp Y028_RICPR 31.683 101 66 3 168 266 47 146 7.05E-08 56.2 Y028_RICPR reviewed Uncharacterized protein RP028 RP028 Rickettsia prowazekii (strain Madrid E) 250 0 0 0 0 0 PF13847; O15031 CHOYP_PLXNB2.4.4 m.60725 sp PLXB2_HUMAN 22.442 557 353 25 40 560 34 547 7.05E-19 95.5 PLXB2_HUMAN reviewed Plexin-B2 (MM1) PLXNB2 KIAA0315 Homo sapiens (Human) 1838 brain development [GO:0007420]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell adhesion [GO:0007162]; neural tube closure [GO:0001843]; neuroblast proliferation [GO:0007405]; positive regulation of axonogenesis [GO:0050772]; positive regulation of neuron projection development [GO:0010976]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of neuron migration [GO:2001222]; regulation of protein phosphorylation [GO:0001932]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287] GO:0001843; GO:0001932; GO:0002116; GO:0005887; GO:0007156; GO:0007162; GO:0007405; GO:0007420; GO:0008360; GO:0009986; GO:0010976; GO:0017154; GO:0030334; GO:0043087; GO:0050772; GO:0070062; GO:0071526; GO:1902287; GO:2001222 0 0 0 PF08337;PF01437;PF01403;PF01833; O46160 CHOYP_RL14.5.9 m.39639 sp RL14_LUMRU 65.714 140 47 1 45 183 5 144 7.05E-60 186 RL14_LUMRU reviewed 60S ribosomal protein L14 RPL14 Lumbricus rubellus (Humus earthworm) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01929; P16157 CHOYP_TVAG_168010.28.45 m.54143 sp ANK1_HUMAN 32.759 348 234 0 1 348 178 525 7.05E-50 183 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P27446 CHOYP_FYN.1.1 m.44311 sp FYN_XIPHE 42.607 399 220 4 288 686 134 523 7.05E-115 358 FYN_XIPHE reviewed Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene c-Fyn) (p59-Fyn) fyn Xiphophorus helleri (Green swordtail) 537 multicellular organism development [GO:0007275] GO:0004715; GO:0005524; GO:0007275; GO:0046872 0 0 0 PF07714;PF00017;PF00018; Q0VCS9 CHOYP_PHUM_PHUM000570.1.1 m.24334 sp ANKY2_BOVIN 40 65 39 0 84 148 320 384 7.05E-08 57 ANKY2_BOVIN reviewed Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 Bos taurus (Bovine) 442 0 GO:0005929; GO:0046872 0 0 0 PF12796;PF01753; Q5G268 CHOYP_NETR.3.3 m.61311 sp NETR_NOMLE 35.455 220 118 9 553 760 278 485 7.05E-22 105 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5RD86 CHOYP_DDA1.1.2 m.51629 sp DDA1_PONAB 56.122 98 43 0 13 110 1 98 7.05E-37 123 DDA1_PONAB reviewed DET1- and DDB1-associated protein 1 DDA1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 102 regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434] GO:0032434 0 0 0 PF10172; Q5UQ35 CHOYP_LOC100372473.2.5 m.35440 sp YR811_MIMIV 23.024 291 191 11 23 299 7 278 7.05E-11 67 YR811_MIMIV reviewed Putative ariadne-like RING finger protein R811 MIMI_R811 Acanthamoeba polyphaga mimivirus (APMV) 990 0 GO:0008270 0 0 0 PF01485; Q6DGQ4 CHOYP_RPAB1.1.1 m.11587 sp CP087_DANRE 29.07 172 89 4 12 181 10 150 7.05E-11 60.8 CP087_DANRE reviewed UPF0547 protein C16orf87 homolog zgc:92818 Danio rerio (Zebrafish) (Brachydanio rerio) 152 0 0 0 0 0 PF10571; Q8K2W3 CHOYP_TXD11.1.1 m.38418 sp TXD11_MOUSE 31.839 870 508 29 21 845 52 881 7.05E-120 389 TXD11_MOUSE reviewed Thioredoxin domain-containing protein 11 Txndc11 Mus musculus (Mouse) 948 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005783; GO:0005789; GO:0006457; GO:0016021; GO:0034976; GO:0045454 0 0 0 PF00085; Q8NBN7 CHOYP_TRIADDRAFT_18543.2.2 m.29752 sp RDH13_HUMAN 43.686 293 152 7 33 315 28 317 7.05E-59 195 RDH13_HUMAN reviewed Retinol dehydrogenase 13 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 7C member 3) RDH13 SDR7C3 PSEC0082 UNQ736/PRO1430 Homo sapiens (Human) 331 eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842] GO:0005743; GO:0009644; GO:0010842; GO:0016491; GO:0042462; GO:0052650 0 0 0 PF00106; Q92193 CHOYP_ACT.20.27 m.57349 sp ACT_CRAVI 95.455 132 6 0 1 132 36 167 7.05E-87 259 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96GP6 CHOYP_LOC579946.21.24 m.58080 sp SREC2_HUMAN 35.747 221 131 8 29 249 236 445 7.05E-23 105 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9UHV9 CHOYP_LOC589720.1.1 m.63687 sp PFD2_HUMAN 57.895 133 51 1 17 144 22 154 7.05E-51 162 PFD2_HUMAN reviewed Prefoldin subunit 2 PFDN2 PFD2 HSPC231 Homo sapiens (Human) 154 positive regulation of cytoskeleton organization [GO:0051495]; protein folding [GO:0006457] GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005739; GO:0006457; GO:0016272; GO:0044183; GO:0051082; GO:0051495; GO:0070062 0 0 0 PF01920; O15553 CHOYP_LOC100376215.8.19 m.32646 sp MEFV_HUMAN 32.787 61 41 0 23 83 373 433 7.06E-06 46.2 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; O70277 CHOYP_BRAFLDRAFT_87279.10.10 m.64641 sp TRIM3_RAT 25.325 154 108 3 38 187 593 743 7.06E-09 58.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; Q24439 CHOYP_LOC100368866.1.1 m.6804 sp ATPO_DROME 47.059 204 107 1 22 225 7 209 7.06E-64 200 ATPO_DROME reviewed "ATP synthase subunit O, mitochondrial (Oligomycin sensitivity conferral protein) (OSCP)" ATPsynO Oscp CG4307 Drosophila melanogaster (Fruit fly) 209 mitochondrial ATP synthesis coupled proton transport [GO:0042776] GO:0005739; GO:0005743; GO:0005811; GO:0042776; GO:0046933 0 0 0 PF00213; Q2KJC3 CHOYP_LOC100721584.1.1 m.52601 sp MPEG1_BOVIN 39.212 584 336 8 19 587 22 601 7.06E-146 446 MPEG1_BOVIN reviewed Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Bos taurus (Bovine) 717 0 GO:0016021 0 0 0 PF01823; Q3B725 CHOYP_LOC100141754.1.1 m.16683 sp ZBT24_RAT 33.632 223 137 5 326 548 298 509 7.06E-31 133 ZBT24_RAT reviewed Zinc finger and BTB domain-containing protein 24 (Bone morphogenetic protein-induced factor 1) (Zinc finger protein 450) Zbtb24 Bif1 Znf450 Rattus norvegicus (Rat) 705 "hematopoietic progenitor cell differentiation [GO:0002244]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0002244; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF00096;PF13912; Q6R7E2 CHOYP_Y077.1.1 m.27639 sp IAP2_OSHVF 99.412 170 1 0 1 170 1 170 7.06E-127 356 IAP2_OSHVF reviewed Putative apoptosis inhibitor ORF87 ORF87 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 170 0 0 0 0 0 PF00653; Q8TB52 CHOYP_FBXO30.1.1 m.48442 sp FBX30_HUMAN 50.538 93 46 0 78 170 5 97 7.06E-27 108 FBX30_HUMAN reviewed F-box only protein 30 FBXO30 FBX30 Homo sapiens (Human) 745 0 GO:0008270; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15966;PF15965; Q8TF01 CHOYP_BRAFLDRAFT_81797.1.1 m.41572 sp PNISR_HUMAN 33.416 404 170 20 1 345 1 364 7.06E-28 120 PNISR_HUMAN reviewed "Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)" PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306 Homo sapiens (Human) 805 0 GO:0005654; GO:0005737; GO:0016607; GO:0044822 0 0 0 PF15996; Q9SAJ7 CHOYP_BRAFLDRAFT_77225.1.2 m.29844 sp MTP9_ARATH 31.454 337 209 5 144 472 66 388 7.06E-48 173 MTP9_ARATH reviewed Metal tolerance protein 9 (AtMTP9) MTP9 At1g79520 T8K14.6 Arabidopsis thaliana (Mouse-ear cress) 402 regulation of sequestering of zinc ion [GO:0061088]; response to zinc ion [GO:0010043] GO:0005385; GO:0005774; GO:0010043; GO:0016020; GO:0016021; GO:0061088 0 0 0 PF01545;PF16916; O60229 CHOYP_KALRN.2.2 m.36644 sp KALRN_HUMAN 55.629 302 133 1 23 324 23 323 7.07E-113 363 KALRN_HUMAN reviewed Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) KALRN DUET DUO HAPIP TRAD Homo sapiens (Human) 2985 ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; protein phosphorylation [GO:0006468]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; vesicle-mediated transport [GO:0016192] GO:0004674; GO:0005085; GO:0005089; GO:0005096; GO:0005524; GO:0005829; GO:0006468; GO:0007165; GO:0007399; GO:0015629; GO:0016192; GO:0035023; GO:0035556; GO:0043065; GO:0046872; GO:0048013; GO:0051056; GO:0070062 0 0 0 PF00650;PF00041;PF07679;PF00169;PF00069;PF00621;PF00435; O96064 CHOYP_MYSP.7.9 m.42318 sp MYSP_MYTGA 75.41 122 30 0 1 122 135 256 7.07E-51 175 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P25007 CHOYP_LOC101156984.1.2 m.19043 sp PPIA_DROME 77.124 153 34 1 34 185 55 207 7.07E-84 250 PPIA_DROME reviewed Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) Cyp1 Cyp-1 CG9916 Drosophila melanogaster (Fruit fly) 227 autophagic cell death [GO:0048102]; protein folding [GO:0006457]; salivary gland cell autophagic cell death [GO:0035071] GO:0003755; GO:0005634; GO:0005737; GO:0005829; GO:0005875; GO:0006457; GO:0035071; GO:0042277; GO:0048102 0 0 0 PF00160; Q17Q97 CHOYP_NEMVEDRAFT_V1G244077.1.1 m.14957 sp CS060_BOVIN 31.25 144 96 1 34 177 38 178 7.07E-20 85.5 CS060_BOVIN reviewed Uncharacterized protein C19orf60 homolog 0 Bos taurus (Bovine) 180 0 0 0 0 0 0 Q502M6 CHOYP_TVAG_033450.4.4 m.61139 sp ANR29_DANRE 39.394 132 80 0 1 132 85 216 7.07E-27 104 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5R4W3 CHOYP_DPOE3.2.2 m.45273 sp DPOE3_PONAB 75.676 74 18 0 1 74 32 105 7.07E-35 120 DPOE3_PONAB reviewed DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) POLE3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 147 histone H3 acetylation [GO:0043966] GO:0003677; GO:0003887; GO:0005671; GO:0008622; GO:0043966 0 0 0 PF00808; Q5RCZ7 CHOYP_BTBD3.2.3 m.10369 sp RCBT2_PONAB 27.612 134 91 2 11 144 380 507 7.07E-12 65.1 RCBT2_PONAB reviewed RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) RCBTB2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 551 0 GO:0001669 0 0 0 PF00651;PF00415; Q5UR67 CHOYP_contig_049670 m.58982 sp RIBX_MIMIV 45.89 146 74 2 312 452 21 166 7.07E-33 125 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q8IZF6 CHOYP_BRAFLDRAFT_66878.1.1 m.38703 sp AGRG4_HUMAN 32.184 435 258 11 2720 3141 2593 3003 7.07E-65 251 AGRG4_HUMAN reviewed Adhesion G-protein coupled receptor G4 (G-protein coupled receptor 112) ADGRG4 GPR112 Homo sapiens (Human) 3080 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0004930; GO:0007166; GO:0007186; GO:0016021 0 0 0 PF00002;PF01825;PF00354; Q91WL8 CHOYP_LOC100888146.1.1 m.58798 sp WWOX_MOUSE 35.161 310 168 8 17 317 126 411 7.07E-41 150 WWOX_MOUSE reviewed WW domain-containing oxidoreductase (EC 1.1.1.-) Wwox Wox1 Mus musculus (Mouse) 414 cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; skeletal system morphogenesis [GO:0048705]; Wnt signaling pathway [GO:0016055] GO:0001649; GO:0005634; GO:0005737; GO:0005739; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0016055; GO:0016491; GO:0019899; GO:0030178; GO:0045944; GO:0048705; GO:0071560; GO:0072332; GO:0090575; GO:0097191; GO:2001238; GO:2001241 0 0 0 PF00106;PF00397; Q9BV23 CHOYP_ABHD6.1.1 m.2082 sp ABHD6_HUMAN 34.328 201 127 4 1 201 137 332 7.07E-37 134 ABHD6_HUMAN reviewed Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6) ABHD6 Homo sapiens (Human) 337 acylglycerol catabolic process [GO:0046464]; long term synaptic depression [GO:0060292]; negative regulation of cell migration [GO:0030336]; phospholipid catabolic process [GO:0009395]; positive regulation of lipid biosynthetic process [GO:0046889]; regulation of endocannabinoid signaling pathway [GO:2000124] GO:0004620; GO:0005739; GO:0005886; GO:0009395; GO:0016021; GO:0030336; GO:0032281; GO:0046464; GO:0046889; GO:0047372; GO:0060292; GO:0070062; GO:2000124 0 0 0 PF00561; Q9D1C9 CHOYP_RRP7A.2.2 m.56539 sp RRP7A_MOUSE 50 106 53 0 2 107 158 263 7.07E-27 102 RRP7A_MOUSE reviewed Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14 homolog) Rrp7a Mus musculus (Mouse) 280 blastocyst formation [GO:0001825]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364] GO:0000028; GO:0000166; GO:0001825; GO:0005737; GO:0006364; GO:0032545; GO:0034456; GO:0044822 0 0 0 PF12923; Q9R1R2 CHOYP_LOC100376214.10.11 m.53363 sp TRIM3_MOUSE 23.529 255 181 4 165 407 492 744 7.07E-14 77 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A6NMZ7 CHOYP_LOC101064693.2.2 m.50877 sp CO6A6_HUMAN 30.798 263 162 6 3 265 554 796 7.08E-30 121 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; C6KFA3 CHOYP_BRAFLDRAFT_73991.1.2 m.6135 sp GP126_DANRE 28.12 633 388 22 468 1055 504 1114 7.08E-63 238 GP126_DANRE reviewed G-protein coupled receptor 126 gpr126 Danio rerio (Zebrafish) (Brachydanio rerio) 1185 cAMP-mediated signaling [GO:0019933]; cell surface receptor signaling pathway [GO:0007166]; ear development [GO:0043583]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; mitochondrion organization [GO:0007005]; myelination [GO:0042552]; myelination in peripheral nervous system [GO:0022011]; myelination of posterior lateral line nerve axons [GO:0048932]; ossification [GO:0001503]; peripheral nervous system myelin formation [GO:0032290]; regulation of sprouting angiogenesis [GO:1903670]; semicircular canal fusion [GO:0060879] GO:0001503; GO:0004930; GO:0005518; GO:0005622; GO:0005886; GO:0007005; GO:0007166; GO:0007186; GO:0007507; GO:0016021; GO:0019933; GO:0022011; GO:0032290; GO:0042552; GO:0043583; GO:0048932; GO:0050840; GO:0060347; GO:0060879; GO:1903670 0 0 0 PF00002;PF00431;PF01825;PF00354; O43301 CHOYP_BRAFLDRAFT_242762.2.8 m.5998 sp HS12A_HUMAN 28.222 450 251 13 22 404 48 492 7.08E-47 173 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O43324 CHOYP_MCA3.1.1 m.5766 sp MCA3_HUMAN 42.857 168 95 1 28 194 6 173 7.08E-43 144 MCA3_HUMAN reviewed Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18) EEF1E1 AIMP3 P18 Homo sapiens (Human) 174 "glutathione metabolic process [GO:0006749]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cellular senescence [GO:2000774]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; tRNA aminoacylation for protein translation [GO:0006418]" GO:0003746; GO:0004364; GO:0005634; GO:0005737; GO:0005829; GO:0006418; GO:0006749; GO:0008285; GO:0043065; GO:0043517; GO:0070062; GO:2000774 0 0 0 PF00043; P18503 CHOYP_BRAFLDRAFT_76449.1.1 m.23074 sp CAS4_EPHMU 31.967 122 69 4 91 212 206 313 7.08E-06 50.1 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P24928 CHOYP_PMAR_PMAR024409.1.3 m.2648 sp RPB1_HUMAN 46.154 117 49 3 125 239 1853 1957 7.08E-16 86.7 RPB1_HUMAN reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) POLR2A POLR2 Homo sapiens (Human) 1970 "7-methylguanosine mRNA capping [GO:0006370]; DNA-templated transcription, termination [GO:0006353]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; gene silencing by RNA [GO:0031047]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of RNA splicing [GO:0033120]; positive regulation of viral transcription [GO:0050434]; regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; somatic stem cell population maintenance [GO:0035019]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000398; GO:0003677; GO:0003899; GO:0003968; GO:0005634; GO:0005654; GO:0005665; GO:0006283; GO:0006353; GO:0006355; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0008543; GO:0010467; GO:0031047; GO:0031625; GO:0033120; GO:0035019; GO:0042795; GO:0044822; GO:0046872; GO:0050434 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; P51955 CHOYP_NEK2.2.3 m.56337 sp NEK2_HUMAN 48.56 486 195 8 72 543 1 445 7.08E-149 437 NEK2_HUMAN reviewed Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1) NEK2 NEK2A NLK1 Homo sapiens (Human) 445 blastocyst development [GO:0001824]; cell division [GO:0051301]; centrosome separation [GO:0051299]; chromosome segregation [GO:0007059]; G2/M transition of mitotic cell cycle [GO:0000086]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; negative regulation of centriole-centriole cohesion [GO:1903126]; negative regulation of DNA binding [GO:0043392]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of mitotic centrosome separation [GO:0046602]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225] GO:0000070; GO:0000086; GO:0000776; GO:0000777; GO:0000794; GO:0000922; GO:0001824; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0005813; GO:0005829; GO:0005874; GO:0006468; GO:0007059; GO:0007067; GO:0007088; GO:0019903; GO:0030496; GO:0032212; GO:0043234; GO:0043392; GO:0046602; GO:0046777; GO:0046872; GO:0051225; GO:0051299; GO:0051301; GO:0051321; GO:0051973; GO:0051988; GO:0090307; GO:1903126; GO:1904355 0 0 0 PF00069; Q0P4S0 CHOYP_LOC100747478.1.1 m.52254 sp LST2_XENTR 63.636 286 104 0 1 286 2 287 7.08E-124 398 LST2_XENTR reviewed Lateral signaling target protein 2 homolog (Zinc finger FYVE domain-containing protein 28) zfyve28 lst2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 951 negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059] GO:0005829; GO:0007175; GO:0031901; GO:0032266; GO:0042059; GO:0046872 0 0 0 PF01363; Q32KR8 CHOYP_BRAFLDRAFT_212086.9.11 m.60590 sp ADPRH_BOVIN 58.405 351 139 4 7 356 8 352 7.08E-135 396 ADPRH_BOVIN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Bos taurus (Bovine) 353 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q52KD8 CHOYP_NR1AA.1.1 m.39229 sp EAF6_XENLA 61.719 128 38 2 10 130 10 133 7.08E-47 154 EAF6_XENLA reviewed Chromatin modification-related protein MEAF6 (MYST/Esa1-associated factor 6) (Esa1-associated factor 6 homolog) (Protein EAF6 homolog) meaf6 Xenopus laevis (African clawed frog) 188 "histone H2A acetylation [GO:0043968]; histone H3-K14 acetylation [GO:0044154]; histone H4-K12 acetylation [GO:0043983]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000776; GO:0000777; GO:0005730; GO:0006351; GO:0006355; GO:0035267; GO:0043968; GO:0043981; GO:0043982; GO:0043983; GO:0044154; GO:0070776 0 0 0 PF09340; Q5U538 CHOYP_LOC100377268.1.1 m.40786 sp HARB1_XENLA 26.519 181 108 6 18 195 156 314 7.08E-07 53.1 HARB1_XENLA reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 Xenopus laevis (African clawed frog) 347 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q5UPG5 CHOYP_LOC100888454.1.1 m.62485 sp YL093_MIMIV 30.108 186 126 4 19 204 231 412 7.08E-13 72.4 YL093_MIMIV reviewed Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) 421 0 0 0 0 0 PF00023;PF12796; Q6EV69 CHOYP_BRAFLDRAFT_87806.1.1 m.28308 sp OFUT1_PANTR 46.742 353 159 8 34 361 29 377 7.08E-103 311 OFUT1_PANTR reviewed GDP-fucose protein O-fucosyltransferase 1 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 1) (O-FucT-1) POFUT1 FUT12 Pan troglodytes (Chimpanzee) 388 angiogenesis [GO:0001525]; fucose metabolic process [GO:0006004]; heart development [GO:0007507]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; protein O-linked glycosylation [GO:0006493]; somitogenesis [GO:0001756] GO:0001525; GO:0001756; GO:0005783; GO:0006004; GO:0006493; GO:0007219; GO:0007399; GO:0007507; GO:0008417; GO:0016020; GO:0046922 PATHWAY: Protein modification; protein glycosylation. 0 0 PF10250; Q7ZYA2 CHOYP_BRAFLDRAFT_214741.1.1 m.52410 sp TAF8_XENLA 47.653 277 134 1 5 270 16 292 7.08E-85 258 TAF8_XENLA reviewed Transcription initiation factor TFIID subunit 8 (TBP-associated factor 8) taf8 Xenopus laevis (African clawed frog) 293 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007275; GO:0030154 0 0 cd08049; PF07524;PF10406; Q8CIB9 CHOYP_LOC101064990.1.1 m.49793 sp ESCO2_MOUSE 51.546 97 46 1 12 108 495 590 7.08E-26 103 ESCO2_MOUSE reviewed N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) Esco2 Mus musculus (Mouse) 592 cell cycle [GO:0007049]; chromosome segregation [GO:0007059]; double-strand break repair [GO:0006302]; hematopoietic progenitor cell differentiation [GO:0002244]; post-translational protein acetylation [GO:0034421]; protein localization to chromatin [GO:0071168]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001741; GO:0002244; GO:0004468; GO:0005634; GO:0005794; GO:0006275; GO:0006302; GO:0007049; GO:0007059; GO:0010369; GO:0031618; GO:0034421; GO:0035861; GO:0046872; GO:0071168 0 0 0 PF13880;PF13878; Q8NBS3 CHOYP_S4A11.1.1 m.4628 sp S4A11_HUMAN 60.345 232 91 1 2 232 645 876 7.08E-81 262 S4A11_HUMAN reviewed Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11) SLC4A11 BTR1 Homo sapiens (Human) 891 bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular cation homeostasis [GO:0030003]; fluid transport [GO:0042044]; proton transport [GO:0015992]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005272; GO:0005452; GO:0005887; GO:0006814; GO:0015106; GO:0015252; GO:0015293; GO:0015301; GO:0015701; GO:0015992; GO:0016323; GO:0030003; GO:0042044; GO:0046713; GO:0046715; GO:0046983; GO:0051453 0 0 0 PF00955; Q8VIG3 CHOYP_QCR2.1.1 m.35613 sp RSPH1_MOUSE 60.833 240 94 0 17 256 17 256 7.08E-95 285 RSPH1_MOUSE reviewed Radial spoke head 1 homolog (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) Rsph1 Tsga2 Mus musculus (Mouse) 301 axoneme assembly [GO:0035082]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286] GO:0000794; GO:0001520; GO:0005634; GO:0005737; GO:0005829; GO:0007286; GO:0031514; GO:0035082; GO:0036126; GO:0051321; GO:0072687 0 0 0 PF02493; Q90Z10 CHOYP_LOC100367312.7.13 m.37565 sp RL13_DANRE 67.633 207 67 0 614 820 5 211 7.08E-86 275 RL13_DANRE reviewed 60S ribosomal protein L13 rpl13 Danio rerio (Zebrafish) (Brachydanio rerio) 211 regulation of cell cycle [GO:0051726]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0051726 0 0 0 PF01294; Q99L04 CHOYP_BRAFLDRAFT_205095.2.2 m.62915 sp DHRS1_MOUSE 52.83 318 135 2 3 314 5 313 7.08E-120 350 DHRS1_MOUSE reviewed Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-) Dhrs1 D14ertd484e Mus musculus (Mouse) 313 0 GO:0005739; GO:0005743; GO:0005783; GO:0016491 0 0 0 PF00106; Q9BYK8 CHOYP_LOC586432.1.2 m.32084 sp HELZ2_HUMAN 30.584 497 286 14 83 547 1880 2349 7.08E-56 206 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9ESN4 CHOYP_LOC794295.1.1 m.42748 sp C1QL3_MOUSE 32.09 134 73 3 60 186 128 250 7.08E-09 57 C1QL3_MOUSE reviewed Complement C1q-like protein 3 (C1q and tumor necrosis factor-related protein 13) (C1q/TNF-related protein 13) (CTRP13) (Gliacolin) C1ql3 C1ql Ctrp13 Mus musculus (Mouse) 255 regulation of synapse organization [GO:0050807] GO:0005576; GO:0005581; GO:0050807 0 0 0 PF00386;PF01391; Q9FN03 CHOYP_BRAFLDRAFT_72132.1.2 m.18149 sp UVR8_ARATH 31.892 370 224 9 802 1164 14 362 7.08E-49 184 UVR8_ARATH reviewed Ultraviolet-B receptor UVR8 (Protein UV-B RESISTANCE 8) (RCC1 domain-containing protein UVR8) UVR8 At5g63860 MGI19.7 Arabidopsis thaliana (Mouse-ear cress) 440 entrainment of circadian clock [GO:0009649]; protein-chromophore linkage [GO:0018298]; response to UV [GO:0009411]; response to UV-B [GO:0010224] GO:0000785; GO:0003682; GO:0005085; GO:0005634; GO:0005829; GO:0009411; GO:0009649; GO:0009881; GO:0010224; GO:0018298; GO:0042803 0 0 0 PF00415; Q9UNN5 CHOYP_FAF1.1.1 m.35621 sp FAF1_HUMAN 42.222 675 347 9 6 675 6 642 7.08E-178 525 FAF1_HUMAN reviewed FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A) FAF1 UBXD12 UBXN3A CGI-03 Homo sapiens (Human) 650 apoptotic process [GO:0006915]; cell death [GO:0008219]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell death [GO:0010942]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein complex assembly [GO:0031334]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176] GO:0005634; GO:0005635; GO:0005829; GO:0006915; GO:0007253; GO:0008219; GO:0010942; GO:0019887; GO:0019901; GO:0030155; GO:0031072; GO:0031265; GO:0031334; GO:0031625; GO:0034098; GO:0042176; GO:0043065; GO:0043130; GO:0043161; GO:0048471; GO:0051059; GO:1902043 0 0 0 PF00789; Q9UPN9 CHOYP_BRAFLDRAFT_74874.3.9 m.37096 sp TRI33_HUMAN 25.366 205 141 4 269 465 229 429 7.08E-06 52.8 TRI33_HUMAN reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) 1127 "negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0045892; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q9Y6K8 CHOYP_VOLCADRAFT_121426.1.1 m.43175 sp KAD5_HUMAN 37.5 440 229 4 384 782 127 561 7.08E-97 320 KAD5_HUMAN reviewed Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) AK5 Homo sapiens (Human) 562 ADP biosynthetic process [GO:0006172]; ATP metabolic process [GO:0046034]; dADP biosynthetic process [GO:0006173]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142]; pyrimidine ribonucleotide biosynthetic process [GO:0009220] GO:0004017; GO:0004550; GO:0005524; GO:0005737; GO:0005815; GO:0005829; GO:0006165; GO:0006172; GO:0006173; GO:0009142; GO:0009220; GO:0015949; GO:0019206; GO:0046034 0 0 cd01428; 0 A0JM12 CHOYP_MEGF6.7.59 m.5874 sp MEG10_XENTR 39.535 215 105 11 179 381 615 816 7.09E-27 116 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; P02637 CHOYP_SCP.11.12 m.66352 sp SCP_MIZYE 37.714 175 102 5 2 175 2 170 7.09E-33 118 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P10076 CHOYP_ZN227.3.3 m.41329 sp ZFP26_MOUSE 33.721 172 98 4 268 434 610 770 7.09E-19 93.2 ZFP26_MOUSE reviewed Zinc finger protein 26 (Zfp-26) (Protein mKR3) Zfp26 Kiaa4196 Mkr3 Zfp-26 Mus musculus (Mouse) 861 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0003700; GO:0005634; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; P20073 CHOYP_ANXA7.2.4 m.30574 sp ANXA7_HUMAN 44.818 357 163 3 219 575 166 488 7.09E-93 296 ANXA7_HUMAN reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 SNX OK/SW-cl.95 Homo sapiens (Human) 488 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; membrane fusion [GO:0061025]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to calcium ion [GO:0051592]; response to organic cyclic compound [GO:0014070]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005178; GO:0005509; GO:0005544; GO:0005634; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0014070; GO:0016020; GO:0030855; GO:0035176; GO:0044822; GO:0048306; GO:0051592; GO:0061025; GO:0070062 0 0 0 PF00191; P28827 CHOYP_LOC578045.5.5 m.65293 sp PTPRM_HUMAN 29.617 601 388 15 528 1110 868 1451 7.09E-70 260 PTPRM_HUMAN reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) PTPRM PTPRL1 Homo sapiens (Human) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005887; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; Q26636 CHOYP_LOC101077542.1.1 m.58180 sp CATL_SARPE 61.783 157 59 1 94 249 183 339 7.09E-66 210 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q2PC93 CHOYP_LOC100497129.2.8 m.22669 sp SSPO_CHICK 40.064 312 165 10 7 308 1290 1589 7.09E-57 221 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q55E58 CHOYP_LOC100313668.6.6 m.60770 sp PATS1_DICDI 22.973 296 179 10 206 489 1764 2022 7.09E-14 80.5 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q6P2W5 CHOYP_BRAFLDRAFT_120154.1.2 m.10962 sp ARGL1_XENTR 59.302 172 52 3 1 158 1 168 7.09E-21 89 ARGL1_XENTR reviewed Arginine and glutamate-rich protein 1 arglu1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 265 0 0 0 0 0 PF15346; Q8K3K9 CHOYP_GIMAP9.1.1 m.45954 sp GIMA4_RAT 31.156 199 128 6 28 223 32 224 7.09E-23 97.1 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8R003 CHOYP_LOC100142119.2.2 m.50757 sp MBNL3_MOUSE 41.299 385 137 11 14 376 9 326 7.09E-82 257 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q90421 CHOYP_DPSE_GA10505.1.1 m.10678 sp LHX3_DANRE 56.707 328 128 3 44 362 25 347 7.09E-122 361 LHX3_DANRE reviewed LIM/homeobox protein Lhx3 (LIM homeobox protein 3) (Homeobox protein LIM-3) lhx3 lim3 Danio rerio (Zebrafish) (Brachydanio rerio) 398 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; ventral spinal cord interneuron specification [GO:0021521]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0021521; GO:0043565 0 0 0 PF00046;PF00412; Q9IA76 CHOYP_NEMVEDRAFT_V1G235042.2.2 m.50874 sp RL31_PAROL 72.414 116 32 0 2 117 6 121 7.09E-59 181 RL31_PAROL reviewed 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) 124 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00463; PF01198; Q9JI18 CHOYP_NEMVEDRAFT_V1G240569.1.1 m.23674 sp LRP1B_MOUSE 35.945 217 114 6 77 275 828 1037 7.09E-28 122 LRP1B_MOUSE reviewed Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) 4599 in utero embryonic development [GO:0001701] GO:0001701; GO:0005041; GO:0005509; GO:0016020; GO:0016021; GO:0043235; GO:0050750 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q9JII1 CHOYP_LOC101070553.1.1 m.9549 sp INP5E_MOUSE 41.138 457 238 6 301 731 195 646 7.09E-121 379 INP5E_MOUSE reviewed "72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV)" Inpp5e Mus musculus (Mouse) 647 inositol phosphate dephosphorylation [GO:0046855]; phosphatidylinositol dephosphorylation [GO:0046856]; phosphatidylinositol metabolic process [GO:0046488]; positive regulation of neuron projection development [GO:0010976] GO:0000139; GO:0001726; GO:0004439; GO:0004445; GO:0005886; GO:0005930; GO:0010976; GO:0032580; GO:0046488; GO:0046855; GO:0046856 0 0 0 PF03372; Q9R0M0 CHOYP_CELR2.4.8 m.31379 sp CELR2_MOUSE 24.898 245 168 8 58 290 1976 2216 7.09E-13 72.8 CELR2_MOUSE reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Flamingo homolog) Celsr2 Mus musculus (Mouse) 2920 "cerebrospinal fluid secretion [GO:0033326]; cilium assembly [GO:0042384]; cilium movement [GO:0003341]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of transcription, DNA-templated [GO:0006355]; ventricular system development [GO:0021591]; Wnt signaling pathway [GO:0016055]" GO:0001764; GO:0003341; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0016021; GO:0016055; GO:0021591; GO:0021999; GO:0032880; GO:0033326; GO:0042384 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9UGM3 CHOYP_BRAFLDRAFT_213459.1.1 m.52157 sp DMBT1_HUMAN 42.326 215 113 6 348 557 494 702 7.09E-36 148 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A4IF63 CHOYP_BRAFLDRAFT_69798.8.22 m.32857 sp TRIM2_BOVIN 22.794 272 154 11 127 349 443 707 7.10E-06 51.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B2KI97 CHOYP_THOC2.2.2 m.19050 sp THOC2_RHIFE 49.886 439 185 4 1 404 882 1320 7.10E-136 428 THOC2_RHIFE reviewed THO complex subunit 2 (Tho2) THOC2 Rhinolophus ferrumequinum (Greater horseshoe bat) 1576 generation of neurons [GO:0048699]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; neuron development [GO:0048666]; RNA splicing [GO:0008380] GO:0003723; GO:0006397; GO:0008380; GO:0016607; GO:0048666; GO:0048699; GO:0051028 0 0 0 PF11262;PF11732;PF16134; G5ED84 CHOYP_ZBTB5.1.4 m.6195 sp KLHL8_CAEEL 29.586 169 108 7 8 172 88 249 7.10E-09 62.8 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O54826 CHOYP_PHUM_PHUM498110.1.1 m.60691 sp AF10_MOUSE 73.797 187 48 1 1 187 18 203 7.10E-102 338 AF10_MOUSE reviewed Protein AF-10 Mllt10 Af10 Mus musculus (Mouse) 1068 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0043234; GO:0045944 0 0 0 0 P07314 CHOYP_LOC100370335.1.1 m.8590 sp GGT1_RAT 34.629 566 336 15 100 647 19 568 7.10E-94 303 GGT1_RAT reviewed Gamma-glutamyltranspeptidase 1 (GGT 1) (EC 2.3.2.2) (Gamma-glutamyltransferase 1) (Glutathione hydrolase 1) (EC 3.4.19.13) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain] Ggt1 Ggt Rattus norvegicus (Rat) 568 aging [GO:0007568]; cellular response to oxidative stress [GO:0034599]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione catabolic process [GO:0006751]; peptide modification [GO:0031179]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to tumor necrosis factor [GO:0034612]; zymogen activation [GO:0031638] GO:0003840; GO:0005615; GO:0005886; GO:0005887; GO:0006536; GO:0006750; GO:0006751; GO:0007568; GO:0031179; GO:0031638; GO:0032355; GO:0032496; GO:0034599; GO:0034612; GO:0036374 PATHWAY: Sulfur metabolism; glutathione metabolism. 0 0 PF01019; P24862 CHOYP_CCNB.1.2 m.9734 sp CCNB_PATVU 74.419 43 11 0 20 62 259 301 7.10E-15 72.8 CCNB_PATVU reviewed G2/mitotic-specific cyclin-B 0 Patella vulgata (Common limpet) 408 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005634; GO:0007067; GO:0051301 0 0 0 PF02984;PF00134; P43236 CHOYP_LOC763308.2.3 m.38511 sp CATK_RABIT 46.483 327 168 3 32 354 6 329 7.10E-103 308 CATK_RABIT reviewed Cathepsin K (EC 3.4.22.38) (Protein OC-2) CTSK Oryctolagus cuniculus (Rabbit) 329 collagen catabolic process [GO:0030574]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of mitophagy [GO:1903146] GO:0004197; GO:0005615; GO:0005764; GO:0030574; GO:0043394; GO:0051603; GO:1903146; GO:1903955 0 0 0 PF08246;PF00112; Q07837 CHOYP_BRAFLDRAFT_265208.1.7 m.5355 sp SLC31_HUMAN 31.912 633 335 21 11 610 81 650 7.10E-83 276 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q3B8D7 CHOYP_BRAFLDRAFT_126379.2.3 m.10977 sp TC1DA_XENLA 40.945 127 71 2 142 267 54 177 7.10E-26 103 TC1DA_XENLA reviewed Tctex1 domain-containing protein 1-A tctex1d1-a Xenopus laevis (African clawed frog) 177 0 0 0 0 0 PF03645; Q4UMH6 CHOYP_LOC755594.3.6 m.51770 sp Y381_RICFE 25.836 329 185 13 304 606 667 962 7.10E-15 82.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5FW46 CHOYP_LOC100031424.1.1 m.7790 sp F214A_XENTR 44.118 408 174 12 876 1270 579 945 7.10E-82 292 F214A_XENTR reviewed Protein FAM214A fam214a TGas096p02.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 946 0 0 0 0 0 PF13889;PF13915; Q5RCU5 CHOYP_LOC100366455.2.3 m.25036 sp CBR1_PONAB 56.458 271 117 1 327 596 7 277 7.10E-107 326 CBR1_PONAB reviewed Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) CBR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 277 drug metabolic process [GO:0017144]; vitamin K metabolic process [GO:0042373] GO:0004090; GO:0005737; GO:0017144; GO:0042373; GO:0047021; GO:0050221 0 0 0 PF00106; Q5RJ54 CHOYP_PRDM5.2.2 m.43638 sp ZSC26_MOUSE 34.759 187 110 4 325 510 288 463 7.10E-23 105 ZSC26_MOUSE reviewed Zinc finger and SCAN domain-containing protein 26 (Zinc finger protein 187) Zscan26 Zfp187 Znf187 Mus musculus (Mouse) 466 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0043565; GO:0046872 0 0 0 PF02023;PF00096; Q6PFY8 CHOYP_TRI33.4.8 m.26631 sp TRI45_MOUSE 28.571 154 97 4 5 153 127 272 7.10E-08 54.3 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9ESN6 CHOYP_BRAFLDRAFT_213530.2.3 m.34104 sp TRIM2_MOUSE 27.168 173 119 4 298 468 536 703 7.10E-07 55.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9UM22 CHOYP_LOC101166335.1.1 m.5463 sp EPDR1_HUMAN 31.628 215 133 5 1 210 19 224 7.10E-38 134 EPDR1_HUMAN reviewed Mammalian ependymin-related protein 1 (MERP-1) (Upregulated in colorectal cancer gene 1 protein) EPDR1 MERP1 UCC1 Homo sapiens (Human) 224 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005764; GO:0007160; GO:0070062 0 0 0 PF00811; A2BIR6 CHOYP_YDJC.1.1 m.4244 sp YDJC_DANRE 39.365 315 155 5 5 294 8 311 7.11E-69 219 YDJC_DANRE reviewed Carbohydrate deacetylase (EC 3.5.1.-) ydjc si:ch211-89f7.6 Danio rerio (Zebrafish) (Brachydanio rerio) 313 carbohydrate metabolic process [GO:0005975] GO:0000287; GO:0005975; GO:0016810 0 0 0 PF04794; E7FCN8 CHOYP_INTU.2.3 m.16830 sp INTU_DANRE 28.969 970 578 26 67 1018 36 912 7.11E-105 352 INTU_DANRE reviewed Protein inturned (Inturned planar cell polarity effector homolog) intu Danio rerio (Zebrafish) (Brachydanio rerio) 915 cilium assembly [GO:0042384]; limb development [GO:0060173]; nervous system development [GO:0007399]; regulation of smoothened signaling pathway [GO:0008589] GO:0005737; GO:0007399; GO:0008589; GO:0009986; GO:0042384; GO:0060173 0 0 0 0 O43303 CHOYP_LOC100373865.1.2 m.61682 sp CP110_HUMAN 37.714 175 98 3 1225 1394 789 957 7.11E-29 129 CP110_HUMAN reviewed Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) CCP110 CEP110 CP110 KIAA0419 Homo sapiens (Human) 1012 centriole replication [GO:0007099]; centrosome duplication [GO:0051298]; ciliary basal body organization [GO:0032053]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of cilium assembly [GO:1902018]; positive regulation of cilium assembly [GO:0045724]; regulation of cytokinesis [GO:0032465] GO:0000086; GO:0005813; GO:0005814; GO:0005829; GO:0005929; GO:0007099; GO:0032053; GO:0032465; GO:0043234; GO:0045724; GO:0051298; GO:1902018 0 0 0 0 O77302 CHOYP_RS10.1.5 m.854 sp RS10_LUMRU 76.282 156 29 2 1 153 1 151 7.11E-80 236 RS10_LUMRU reviewed 40S ribosomal protein S10 RPS10 Lumbricus rubellus (Humus earthworm) 156 0 GO:0005840 0 0 0 PF03501; P12001 CHOYP_BRAFLDRAFT_118793.1.1 m.20796 sp RL18_RAT 73.714 175 46 0 1 175 1 175 7.11E-95 276 RL18_RAT reviewed 60S ribosomal protein L18 Rpl18 Rattus norvegicus (Rat) 188 liver regeneration [GO:0097421]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0097421 0 0 0 PF17135; P62184 CHOYP_CALM.46.50 m.58398 sp CALM_RENRE 57.432 148 61 2 2 148 3 149 7.11E-52 164 CALM_RENRE reviewed Calmodulin (CaM) 0 Renilla reniformis (Sea pansy) 149 0 GO:0005509 0 0 0 PF13499; Q03145 CHOYP_LOC100881175.2.2 m.47844 sp EPHA2_MOUSE 35.099 302 176 8 976 1269 616 905 7.11E-48 191 EPHA2_MOUSE reviewed Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2) Epha2 Eck Myk2 Sek2 Mus musculus (Mouse) 977 activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel morphogenesis [GO:0048514]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production [GO:0001818]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of protein kinase B signaling [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; post-anal tail morphogenesis [GO:0036342]; protein kinase B signaling [GO:0043491]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570] GO:0001501; GO:0001568; GO:0001570; GO:0001649; GO:0001818; GO:0002043; GO:0004714; GO:0005003; GO:0005524; GO:0005622; GO:0005886; GO:0005887; GO:0005925; GO:0006954; GO:0007155; GO:0008630; GO:0009986; GO:0010591; GO:0014028; GO:0016477; GO:0016525; GO:0021915; GO:0030182; GO:0030216; GO:0030316; GO:0031256; GO:0031258; GO:0032587; GO:0032682; GO:0033598; GO:0033628; GO:0036342; GO:0043491; GO:0043535; GO:0045765; GO:0046849; GO:0048013; GO:0048320; GO:0048514; GO:0048570; GO:0050830; GO:0051898; GO:0060035; GO:0060326; GO:0060444; GO:0070309; GO:0070372; GO:0070848; GO:0090004; GO:0090630; GO:1901491; GO:1904238 0 0 0 PF14575;PF01404;PF00041;PF07714;PF00536; Q04833 CHOYP_CBG11882.2.2 m.41670 sp LRP_CAEEL 47.368 76 39 1 806 880 1275 1350 7.11E-14 80.5 LRP_CAEEL reviewed Low-density lipoprotein receptor-related protein (LRP) lrp-1 F29D11.1 Caenorhabditis elegans 4753 "ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; endocytosis [GO:0006897]; nematode larval development [GO:0002119]; positive regulation of locomotion [GO:0040017]; positive regulation of multicellular organism growth [GO:0040018]; regulation of cell migration [GO:0030334]; sterol transport [GO:0015918]" GO:0002119; GO:0005509; GO:0005905; GO:0006897; GO:0015248; GO:0015918; GO:0016021; GO:0016324; GO:0030139; GO:0030334; GO:0040017; GO:0040018; GO:0042395 0 0 0 PF00057;PF00058; Q07553 CHOYP_LOC580109.2.3 m.26742 sp GCY3E_DROME 38.819 237 135 4 396 622 815 1051 7.11E-46 180 GCY3E_DROME reviewed Guanylate cyclase 32E (EC 4.6.1.2) Gyc32E GC CG33114 Drosophila melanogaster (Fruit fly) 1163 cGMP biosynthetic process [GO:0006182]; cGMP-mediated signaling [GO:0019934]; signal transduction [GO:0007165] GO:0004383; GO:0004872; GO:0005524; GO:0005525; GO:0005886; GO:0005887; GO:0006182; GO:0007165; GO:0008074; GO:0019934 0 0 0 PF01094;PF00211;PF07714; Q08BT9 CHOYP_BRAFLDRAFT_96228.1.1 m.45042 sp P20D1_XENTR 41.81 464 238 4 8 442 18 478 7.11E-130 387 P20D1_XENTR reviewed Probable carboxypeptidase PM20D1 (EC 3.4.17.-) (Peptidase M20 domain-containing protein 1) pm20d1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 512 peptide catabolic process [GO:0043171] GO:0005576; GO:0008270; GO:0043171; GO:0070573 0 0 0 PF07687;PF01546; Q09069 CHOYP_EF-1A.7.9 m.46916 sp EF1A_SORMA 65.289 121 40 2 1 121 1 119 7.11E-43 149 EF1A_SORMA reviewed Elongation factor 1-alpha (EF-1-alpha) TEF Sordaria macrospora 460 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q0E908 CHOYP_BRAFLDRAFT_69505.1.4 m.7329 sp HIL_DROME 25.703 498 337 9 5 492 309 783 7.11E-47 184 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q14651 CHOYP_FIM.1.1 m.37221 sp PLSI_HUMAN 42.012 169 94 2 6 171 5 172 7.11E-37 137 PLSI_HUMAN reviewed Plastin-1 (Intestine-specific plastin) (I-plastin) PLS1 Homo sapiens (Human) 629 intestinal D-glucose absorption [GO:0001951]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of multicellular organism growth [GO:0040018]; regulation of microvillus length [GO:0032532]; terminal web assembly [GO:1902896] GO:0001951; GO:0005200; GO:0005509; GO:0005903; GO:0032532; GO:0040018; GO:0051015; GO:0070062; GO:0090004; GO:1902896; GO:1990357 0 0 0 PF00307;PF13499; Q6GMG8 CHOYP_NEMVEDRAFT_V1G129909.4.9 m.22808 sp LITAF_DANRE 44.262 122 56 3 1 114 45 162 7.11E-25 95.1 LITAF_DANRE reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) litaf zgc:91882 Danio rerio (Zebrafish) (Brachydanio rerio) 163 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006355 0 0 0 PF10601; Q9D7P6 CHOYP_ISCU.1.1 m.37414 sp ISCU_MOUSE 74.51 153 36 2 69 218 10 162 7.11E-79 236 ISCU_MOUSE reviewed "Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein)" Iscu Nifun Mus musculus (Mouse) 168 [2Fe-2S] cluster assembly [GO:0044571]; cellular iron ion homeostasis [GO:0006879]; protein maturation by iron-sulfur cluster transfer [GO:0097428] GO:0005737; GO:0005739; GO:0005759; GO:0005829; GO:0006879; GO:0008198; GO:0032947; GO:0036455; GO:0044571; GO:0051537; GO:0051539; GO:0097428 0 0 cd06664; PF01592; Q9ESN6 CHOYP_BRAFLDRAFT_88218.8.8 m.64733 sp TRIM2_MOUSE 27.619 210 134 8 262 460 505 707 7.11E-13 74.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HCB6 CHOYP_LOC100868257.1.1 m.64428 sp SPON1_HUMAN 30.386 622 328 21 58 619 72 648 7.11E-71 247 SPON1_HUMAN reviewed Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) SPON1 KIAA0762 VSGP Homo sapiens (Human) 807 cell adhesion [GO:0007155]; protein O-linked fucosylation [GO:0036066] GO:0005578; GO:0005615; GO:0005788; GO:0007155; GO:0036066; GO:0046872 0 0 cd08544; PF02014;PF06468;PF00090; Q9UKR8 CHOYP_contig_004666 m.5360 sp TSN16_HUMAN 33.333 78 51 1 1 77 86 163 7.11E-06 45.8 TSN16_HUMAN reviewed Tetraspanin-16 (Tspan-16) (Tetraspanin TM4-B) (Transmembrane 4 superfamily member 16) TSPAN16 TM4SF16 Homo sapiens (Human) 245 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166; GO:0016021 0 0 0 PF00335; Q9V5L3 CHOYP_C49A1.1.2 m.5771 sp C49A1_DROME 42.222 90 44 2 8 94 486 570 7.11E-18 80.5 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q9Y6Y1 CHOYP_CMTA1.1.2 m.1635 sp CMTA1_HUMAN 57.143 91 38 1 4 94 1545 1634 7.11E-25 102 CMTA1_HUMAN reviewed Calmodulin-binding transcription activator 1 CAMTA1 KIAA0833 MSTP023 Homo sapiens (Human) 1673 neuromuscular process controlling balance [GO:0050885]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001077; GO:0005634; GO:0005737; GO:0043565; GO:0045944; GO:0050885 0 0 0 PF03859;PF00612;PF01833; O01761 CHOYP_LOC100367089.1.4 m.1396 sp UNC89_CAEEL 42.373 59 33 1 135 192 5487 5545 7.12E-06 49.3 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O75382 CHOYP_BRAFLDRAFT_87322.10.10 m.64718 sp TRIM3_HUMAN 27.273 121 84 2 138 256 625 743 7.12E-07 53.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P21757 CHOYP_BRAFLDRAFT_86428.1.1 m.42758 sp MSRE_HUMAN 48.571 105 53 1 5 109 348 451 7.12E-29 120 MSRE_HUMAN reviewed Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD antigen CD204) MSR1 SCARA1 Homo sapiens (Human) 451 cellular response to organic cyclic compound [GO:0071407]; cholesterol transport [GO:0030301]; lipoprotein transport [GO:0042953]; plasma lipoprotein particle clearance [GO:0034381]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005581; GO:0005829; GO:0005886; GO:0005887; GO:0006898; GO:0010744; GO:0010886; GO:0030169; GO:0030301; GO:0030666; GO:0034362; GO:0034381; GO:0042953; GO:0071407 0 0 0 PF01391;PF03523;PF00530; P62313 CHOYP_BRAFLDRAFT_125735.1.3 m.26333 sp LSM6_MOUSE 98.684 76 1 0 28 103 4 79 7.12E-51 157 LSM6_MOUSE reviewed U6 snRNA-associated Sm-like protein LSm6 Lsm6 Mus musculus (Mouse) 80 "maturation of SSU-rRNA [GO:0030490]; mRNA catabolic process [GO:0006402]; mRNA splicing, via spliceosome [GO:0000398]; tRNA processing [GO:0008033]" GO:0000398; GO:0000932; GO:0003723; GO:0005681; GO:0005688; GO:0005730; GO:0005732; GO:0005737; GO:0006402; GO:0008033; GO:0030490; GO:0044822; GO:0046540; GO:0046982; GO:0070062 0 0 0 PF01423; Q2FXL6 CHOYP_LOC100180855.1.4 m.29179 sp Y1819_STAA8 33.813 139 87 4 15 150 7 143 7.12E-12 62.8 Y1819_STAA8 reviewed Putative universal stress protein SAOUHSC_01819 SAOUHSC_01819 Staphylococcus aureus (strain NCTC 8325) 166 response to stress [GO:0006950] GO:0005737; GO:0006950 0 0 0 PF00582; Q4R684 CHOYP_TTHERM_00947500.1.1 m.33175 sp AMZ2_MACFA 34.44 241 119 6 52 262 58 289 7.12E-43 152 AMZ2_MACFA reviewed Archaemetzincin-2 (EC 3.4.-.-) (Archeobacterial metalloproteinase-like protein 2) AMZ2 QtsA-18820 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 360 0 GO:0008237; GO:0008270 0 0 cd11375; PF07998; Q64261 CHOYP_LOC100371039.1.1 m.18908 sp CDK6_MOUSE 61.356 295 114 0 77 371 8 302 7.12E-141 407 CDK6_MOUSE reviewed Cyclin-dependent kinase 6 (EC 2.7.11.22) (CR2 protein kinase) (CRK2) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) Cdk6 Cdkn6 Crk2 Mus musculus (Mouse) 326 cell cycle [GO:0007049]; cell dedifferentiation [GO:0043697]; cell division [GO:0051301]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; gliogenesis [GO:0042063]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell differentiation [GO:0060218]; hemopoiesis [GO:0030097]; negative regulation of cell cycle [GO:0045786]; negative regulation of cellular senescence [GO:2000773]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of osteoblast differentiation [GO:0045668]; Notch signaling pathway [GO:0007219]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; protein phosphorylation [GO:0006468]; regulation of erythrocyte differentiation [GO:0045646]; regulation of gene expression [GO:0010468]; response to virus [GO:0009615]; T cell differentiation in thymus [GO:0033077]; type B pancreatic cell development [GO:0003323] GO:0000307; GO:0001726; GO:0001954; GO:0002244; GO:0003323; GO:0004693; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006468; GO:0007049; GO:0007219; GO:0009615; GO:0010468; GO:0010628; GO:0016301; GO:0030097; GO:0030332; GO:0033077; GO:0042063; GO:0043697; GO:0045638; GO:0045646; GO:0045656; GO:0045668; GO:0045786; GO:0048146; GO:0050680; GO:0051301; GO:0060218; GO:0097132; GO:1904628; GO:2000773 0 0 0 PF00069; Q8IS44 CHOYP_LOC762961.4.5 m.49873 sp DRD2L_DROME 26.087 276 174 8 38 304 81 335 7.12E-10 64.3 DRD2L_DROME reviewed Dopamine D2-like receptor (DD2R) Dop2R D2R CG17004 Drosophila melanogaster (Fruit fly) 506 "dopamine receptor signaling pathway [GO:0007212]; G-protein coupled receptor signaling pathway [GO:0007186]; synaptic transmission, dopaminergic [GO:0001963]" GO:0001588; GO:0001963; GO:0004930; GO:0004952; GO:0005887; GO:0007186; GO:0007212; GO:0008227; GO:0016021; GO:0035240 0 0 0 PF00001; Q8R151 CHOYP_ZNFX1.3.12 m.15053 sp ZNFX1_MOUSE 39.939 656 289 12 122 689 912 1550 7.12E-134 437 ZNFX1_MOUSE reviewed NFX1-type zinc finger-containing protein 1 Znfx1 Mus musculus (Mouse) 1909 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q8R412 CHOYP_MIB.2.3 m.30418 sp IF27A_MOUSE 61.429 70 27 0 156 225 7 76 7.12E-15 72 IF27A_MOUSE reviewed Interferon alpha-inducible protein 27-like protein 2A (Interferon-stimulated gene 12 protein) (ISG12) Ifi27l2a Ifi27 Isg12 Mus musculus (Mouse) 90 aging [GO:0007568]; response to virus [GO:0009615] GO:0007568; GO:0009615; GO:0016021 0 0 0 PF06140; Q9BXJ4 CHOYP_LOC100702659.1.1 m.20349 sp C1QT3_HUMAN 31.387 137 81 4 119 253 117 242 7.12E-11 63.9 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9NW07 CHOYP_ZNF22.1.1 m.12078 sp ZN358_HUMAN 51.485 101 49 0 92 192 234 334 7.12E-33 126 ZN358_HUMAN reviewed Zinc finger protein 358 ZNF358 Homo sapiens (Human) 568 "embryonic forelimb morphogenesis [GO:0035115]; neural tube development [GO:0021915]; regulation of transcription, DNA-templated [GO:0006355]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0019827; GO:0021915; GO:0035115; GO:0046872 0 0 0 PF00096;PF13912; A7YY35 CHOYP_IFRX2.2.10 m.5186 sp K2012_BOVIN 30.672 238 130 7 8 237 2 212 7.13E-20 100 K2012_BOVIN reviewed Uncharacterized protein KIAA2012 homolog KIAA2012 Bos taurus (Bovine) 1147 0 0 0 0 0 PF15709; A8DYE2 CHOYP_TRPM1.2.4 m.31872 sp TRPCG_DROME 22.736 497 294 21 202 670 369 803 7.13E-10 66.6 TRPCG_DROME reviewed "Transient receptor potential cation channel trpm (Transient receptor potential cation channel, subfamily M ortholog)" Trpm CG44240 Drosophila melanogaster (Fruit fly) 2023 cell growth [GO:0016049]; divalent metal ion transport [GO:0070838]; magnesium ion homeostasis [GO:0010960]; mitochondrion organization [GO:0007005]; protein tetramerization [GO:0051262]; zinc ion homeostasis [GO:0055069] GO:0005261; GO:0007005; GO:0010960; GO:0016049; GO:0034703; GO:0046873; GO:0051262; GO:0055069; GO:0070838; GO:0097682 0 0 0 PF00520;PF16519; B1A8Z2 CHOYP_LOC756594.1.1 m.2979 sp CIB1_SHEEP 50.262 191 88 3 1 184 1 191 7.13E-58 182 CIB1_SHEEP reviewed Calcium and integrin-binding protein 1 (Calmyrin) CIB1 Ovis aries (Sheep) 191 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell division [GO:0051301]; integrin-mediated signaling pathway [GO:0007229]; spermatogenesis [GO:0007283] GO:0001525; GO:0005509; GO:0005634; GO:0005815; GO:0006915; GO:0007049; GO:0007155; GO:0007229; GO:0007283; GO:0016324; GO:0030027; GO:0030154; GO:0030426; GO:0032433; GO:0032587; GO:0042383; GO:0048471; GO:0051301 0 0 0 PF13499; O88281 CHOYP_MEG10.19.91 m.24289 sp MEGF6_RAT 36.5 400 228 15 1 391 529 911 7.13E-49 181 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P11678 CHOYP_EPX.1.1 m.57481 sp PERE_HUMAN 39.219 589 311 17 135 694 145 715 7.13E-123 385 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P16423 CHOYP_LOC100890133.3.3 m.52374 sp POLR_DROME 31.792 173 112 3 7 176 446 615 7.13E-18 88.6 POLR_DROME reviewed Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM) [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1057 0 GO:0003964; GO:0004190; GO:0004519; GO:0046872 0 0 0 PF00078; P30681 CHOYP_SX18B.1.1 m.50112 sp HMGB2_MOUSE 31.461 89 56 1 22 110 95 178 7.13E-07 53.9 HMGB2_MOUSE reviewed High mobility group protein B2 (High mobility group protein 2) (HMG-2) Hmgb2 Hmg2 Mus musculus (Mouse) 210 "cell chemotaxis [GO:0060326]; cellular response to lipopolysaccharide [GO:0071222]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; DNA recombination [GO:0006310]; DNA topological change [GO:0006265]; inflammatory response to antigenic stimulus [GO:0002437]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of DNA binding [GO:0043388]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of megakaryocyte differentiation [GO:0045654]; positive regulation of nuclease activity [GO:0032075]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of neurogenesis [GO:0050767]; regulation of stem cell proliferation [GO:0072091]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to lipopolysaccharide [GO:0032496]; response to steroid hormone [GO:0048545]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000790; GO:0000793; GO:0001158; GO:0001938; GO:0002437; GO:0003677; GO:0003684; GO:0003690; GO:0003700; GO:0005615; GO:0005623; GO:0005634; GO:0005730; GO:0005737; GO:0006265; GO:0006310; GO:0006351; GO:0006357; GO:0007283; GO:0007289; GO:0008134; GO:0008301; GO:0008584; GO:0010628; GO:0010629; GO:0019904; GO:0032075; GO:0032496; GO:0032728; GO:0042056; GO:0043234; GO:0043388; GO:0044212; GO:0044378; GO:0044822; GO:0045087; GO:0045089; GO:0045648; GO:0045654; GO:0045892; GO:0045893; GO:0045944; GO:0048471; GO:0048545; GO:0050767; GO:0050786; GO:0050829; GO:0050830; GO:0060326; GO:0071222; GO:0072091; GO:0097100; GO:1902042 0 0 0 PF00505;PF09011; P41236 CHOYP_ISCW_ISCW010143.3.3 m.61542 sp IPP2_HUMAN 43.902 164 79 4 2 157 3 161 7.13E-30 112 IPP2_HUMAN reviewed Protein phosphatase inhibitor 2 (IPP-2) PPP1R2 IPP2 Homo sapiens (Human) 205 generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of signal transduction [GO:0009966] GO:0000164; GO:0004865; GO:0005977; GO:0006091; GO:0009966; GO:0043666 0 0 0 PF04979; P54366 CHOYP_TSP_07961.1.1 m.11132 sp GSC_DROME 86.364 66 9 0 86 151 280 345 7.13E-35 131 GSC_DROME reviewed Homeobox protein goosecoid Gsc CG2851 Drosophila melanogaster (Fruit fly) 415 "multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]" GO:0001078; GO:0005634; GO:0007275; GO:0042803; GO:0043565; GO:0045892; GO:0046982 0 0 0 PF00046; Q01705 CHOYP_BRAFLDRAFT_83984.2.2 m.65896 sp NOTC1_MOUSE 55.422 83 37 0 500 582 1145 1227 7.13E-23 107 NOTC1_MOUSE reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] Notch1 Motch Mus musculus (Mouse) 2531 "aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation [GO:0030154]; cell differentiation in spinal cord [GO:0021515]; cell fate commitment [GO:0045165]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium morphogenesis [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; endocardial cell differentiation [GO:0060956]; endocardial cushion development [GO:0003197]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epidermis development [GO:0008544]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glial cell differentiation [GO:0010001]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; humoral immune response [GO:0006959]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell death [GO:0060548]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; neuron differentiation [GO:0030182]; neuron fate commitment [GO:0048663]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; organ regeneration [GO:0031100]; osteoblast fate commitment [GO:0002051]; pericardium morphogenesis [GO:0003344]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of ephrin receptor signaling pathway [GO:1901189]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral transcription [GO:0050434]; prostate gland epithelium morphogenesis [GO:0060740]; pulmonary valve morphogenesis [GO:0003184]; regulation of auditory receptor cell differentiation [GO:0045607]; regulation of cell adhesion involved in heart morphogenesis [GO:0061344]; regulation of cell migration [GO:0030334]; regulation of cell proliferation [GO:0042127]; regulation of epithelial cell proliferation [GO:0050678]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of gene expression [GO:0010468]; regulation of neurogenesis [GO:0050767]; regulation of Notch signaling pathway [GO:0008593]; regulation of somitogenesis [GO:0014807]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; tissue regeneration [GO:0042246]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous blood vessel morphogenesis [GO:0048845]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0000139; GO:0001047; GO:0001190; GO:0001669; GO:0001701; GO:0001708; GO:0001726; GO:0001837; GO:0001889; GO:0001947; GO:0002040; GO:0002051; GO:0002052; GO:0002193; GO:0002437; GO:0003157; GO:0003160; GO:0003162; GO:0003169; GO:0003180; GO:0003181; GO:0003184; GO:0003192; GO:0003197; GO:0003198; GO:0003203; GO:0003207; GO:0003208; GO:0003209; GO:0003213; GO:0003214; GO:0003219; GO:0003222; GO:0003241; GO:0003256; GO:0003270; GO:0003273; GO:0003344; GO:0003682; GO:0003700; GO:0004857; GO:0004872; GO:0005112; GO:0005509; GO:0005576; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005789; GO:0005829; GO:0005856; GO:0005886; GO:0005887; GO:0005912; GO:0006357; GO:0006959; GO:0007219; GO:0007220; GO:0007221; GO:0007283; GO:0007368; GO:0007386; GO:0007409; GO:0007440; GO:0007492; GO:0007507; GO:0008284; GO:0008285; GO:0008544; GO:0008593; GO:0009912; GO:0009986; GO:0010001; GO:0010468; GO:0010718; GO:0010812; GO:0010832; GO:0014031; GO:0014807; GO:0016324; GO:0019899; GO:0021515; GO:0021915; GO:0030027; GO:0030154; GO:0030182; GO:0030216; GO:0030279; GO:0030324; GO:0030326; GO:0030334; GO:0030335; GO:0030513; GO:0030514; GO:0030900; GO:0031069; GO:0031100; GO:0031410; GO:0031490; GO:0031960; GO:0032495; GO:0032496; GO:0035116; GO:0035148; GO:0035914; GO:0035924; GO:0042127; GO:0042246; GO:0043065; GO:0043086; GO:0043235; GO:0043565; GO:0045070; GO:0045165; GO:0045596; GO:0045603; GO:0045607; GO:0045608; GO:0045618; GO:0045662; GO:0045665; GO:0045668; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0045955; GO:0046427; GO:0046533; GO:0046982; GO:0048103; GO:0048663; GO:0048708; GO:0048709; GO:0048711; GO:0048715; GO:0048754; GO:0048845; GO:0050434; GO:0050678; GO:0050679; GO:0050767; GO:0050768; GO:0055008; GO:0060038; GO:0060045; GO:0060253; GO:0060271; GO:0060317; GO:0060411; GO:0060412; GO:0060528; GO:0060548; GO:0060740; GO:0060768; GO:0060842; GO:0060843; GO:0060948; GO:0060956; GO:0060979; GO:0060982; GO:0061314; GO:0061344; GO:0061384; GO:0061419; GO:0070986; GO:0071372; GO:0071944; GO:0072017; GO:0072044; GO:0072144; GO:0072602; GO:0090051; GO:0090090; GO:0097150; GO:1901189; GO:1901201; GO:1902263; GO:1903849; GO:2000737; GO:2000811; GO:2000974; GO:2001027 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; Q3L254 CHOYP_WNT7B.1.2 m.36042 sp WNT7B_CHICK 65.244 328 110 3 23 348 24 349 7.13E-162 459 WNT7B_CHICK reviewed Protein Wnt-7b WNT7B Gallus gallus (Chicken) 349 cell fate commitment [GO:0045165]; lens fiber cell development [GO:0070307]; neuron differentiation [GO:0030182]; Wnt signaling pathway [GO:0016055] GO:0005109; GO:0005578; GO:0005615; GO:0016055; GO:0030182; GO:0045165; GO:0070307 0 0 0 PF00110; Q58CV6 CHOYP_KLDC3.1.1 m.33200 sp KLDC3_BOVIN 59.843 381 147 2 1 376 1 380 7.13E-171 484 KLDC3_BOVIN reviewed Kelch domain-containing protein 3 KLHDC3 Bos taurus (Bovine) 382 meiotic cell cycle [GO:0051321] GO:0005737; GO:0051321 0 0 0 PF07646; Q5W5X9 CHOYP_LOC752904.1.1 m.18075 sp TTC23_HUMAN 31.156 398 264 4 76 469 25 416 7.13E-55 193 TTC23_HUMAN reviewed Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8) TTC23 HCC8 Homo sapiens (Human) 447 0 0 0 0 0 0 Q6ZRF8 CHOYP_LOC100374981.14.16 m.65258 sp RN207_HUMAN 21.359 206 146 7 16 219 103 294 7.13E-09 61.6 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q80T91 CHOYP_MEG10.9.91 m.20215 sp MEG11_MOUSE 35.081 553 280 27 149 655 304 823 7.13E-65 235 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8N7Z5 CHOYP_ANKRD31.1.1 m.63698 sp ANR31_HUMAN 41.346 104 61 0 49 152 1148 1251 7.13E-15 82.8 ANR31_HUMAN reviewed Putative ankyrin repeat domain-containing protein 31 ANKRD31 Homo sapiens (Human) 1873 0 0 0 0 0 PF00023;PF12796; Q8N8A2 CHOYP_LOC589750.5.5 m.65180 sp ANR44_HUMAN 23.687 1047 643 28 957 1955 11 949 7.13E-47 188 ANR44_HUMAN reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (PP6-ARS-B) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B) (Ankyrin repeat domain-containing protein 44) ANKRD44 Homo sapiens (Human) 993 0 0 0 0 0 PF00023;PF12796; Q9CR40 CHOYP_LOC100371852.1.1 m.22627 sp KLH28_MOUSE 28.571 140 95 4 11 147 15 152 7.13E-08 59.3 KLH28_MOUSE reviewed Kelch-like protein 28 (BTB/POZ domain-containing protein 5) Klhl28 Btbd5 Mus musculus (Mouse) 571 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0031463; GO:0042787 0 0 0 PF07707;PF00651;PF01344; Q9CR40 CHOYP_NEMVEDRAFT_V1G120526.5.5 m.37047 sp KLH28_MOUSE 28.571 140 95 4 11 147 15 152 7.13E-08 58.9 KLH28_MOUSE reviewed Kelch-like protein 28 (BTB/POZ domain-containing protein 5) Klhl28 Btbd5 Mus musculus (Mouse) 571 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0031463; GO:0042787 0 0 0 PF07707;PF00651;PF01344; Q9Z1M8 CHOYP_RED.1.2 m.8931 sp RED_MOUSE 58.101 358 118 6 1 352 1 332 7.13E-113 368 RED_MOUSE reviewed Protein Red (Cytokine IK) (IK factor) (Protein RER) Ik Red Rer Mus musculus (Mouse) 557 0 GO:0005654; GO:0005730; GO:0042802 0 0 0 PF07807;PF07808; A2VCL2 CHOYP_LOC579367.1.1 m.31309 sp CC162_HUMAN 35.239 857 517 8 1337 2183 1 829 7.14E-156 510 CC162_HUMAN reviewed Coiled-coil domain-containing protein 162 (Coiled-coil domain-containing protein 162 pseudogene) CCDC162P C6orf184 C6orf185 CCDC162 Homo sapiens (Human) 907 0 0 0 0 0 0 P0C872 CHOYP_BRAFLDRAFT_90706.1.2 m.26625 sp JMJD7_MOUSE 52.104 309 147 1 4 311 2 310 7.14E-126 365 JMJD7_MOUSE reviewed JmjC domain-containing protein 7 (Jumonji domain-containing protein 7) Jmjd7 Mus musculus (Mouse) 316 0 0 0 0 0 0 P10079 CHOYP_EGF1.2.2 m.51145 sp FBP1_STRPU 51.884 345 166 0 104 448 175 519 7.14E-104 364 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10079 CHOYP_LOC663838.2.2 m.43318 sp FBP1_STRPU 42.857 490 266 8 3221 3701 450 934 7.14E-108 377 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P31674 CHOYP_BRAFLDRAFT_99641.1.1 m.63669 sp RS15_ORYSJ 77.982 109 24 0 1 109 37 145 7.14E-59 181 RS15_ORYSJ reviewed 40S ribosomal protein S15 RPS15 Os07g0184300 LOC_Os07g08660 OJ1046_F10.119 Oryza sativa subsp. japonica (Rice) 154 ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412] GO:0000028; GO:0003723; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF00203; P42575 CHOYP_LOC100638885.2.4 m.35434 sp CASP2_HUMAN 27.7 213 104 8 106 298 191 373 7.14E-14 77 CASP2_HUMAN reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 NEDD2 Homo sapiens (Human) 452 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aging [GO:0007568]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ectopic germ cell programmed cell death [GO:0035234]; execution phase of apoptosis [GO:0097194]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; luteolysis [GO:0001554]; neural retina development [GO:0003407]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of neuron apoptotic process [GO:0043525]; protein processing [GO:0016485]; regulation of apoptotic process [GO:0042981]" GO:0001554; GO:0003407; GO:0004197; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0006919; GO:0006977; GO:0007420; GO:0007568; GO:0008630; GO:0016020; GO:0016485; GO:0019899; GO:0019904; GO:0035234; GO:0042981; GO:0043065; GO:0043525; GO:0071260; GO:0097153; GO:0097190; GO:0097192; GO:0097194; GO:2001235 0 0 0 PF00619; P58283 CHOYP_BRAFLDRAFT_117374.1.1 m.17130 sp RN216_MOUSE 38.562 612 319 16 762 1322 162 767 7.14E-97 333 RN216_MOUSE reviewed E3 ubiquitin-protein ligase RNF216 (EC 6.3.2.-) (RING finger protein 216) (Triad domain-containing protein 3) (UbcM4-interacting protein 83) (Ubiquitin-conjugating enzyme 7-interacting protein 1) Rnf216 Triad3 Ubce7ip1 Uip83 Zin Mus musculus (Mouse) 853 apoptotic process [GO:0006915]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein linear polyubiquitination [GO:0097039]; regulation of defense response to virus by host [GO:0050691]; regulation of interferon-beta production [GO:0032648] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0006915; GO:0016874; GO:0032648; GO:0043130; GO:0043161; GO:0046872; GO:0050691; GO:0061630; GO:0070936; GO:0097039 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 P59222 CHOYP_LOC579946.3.24 m.24815 sp SREC2_MOUSE 38.384 99 56 3 201 299 265 358 7.14E-10 64.3 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; Q24537 CHOYP_HMG2.1.1 m.57315 sp HMG2_DROME 51.695 118 53 2 1 114 233 350 7.14E-33 122 HMG2_DROME reviewed High mobility group protein DSP1 (Protein dorsal switch 1) Dsp1 ssrp2 CG12223 Drosophila melanogaster (Fruit fly) 393 "chromatin remodeling [GO:0006338]; developmental process [GO:0032502]; DNA unwinding involved in DNA replication [GO:0006268]; leg disc development [GO:0035218]; negative regulation of antimicrobial humoral response [GO:0008348]; negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0017055]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA binding [GO:0043388]; segment specification [GO:0007379]" GO:0000122; GO:0003677; GO:0003697; GO:0005634; GO:0005700; GO:0006268; GO:0006338; GO:0007379; GO:0008134; GO:0008301; GO:0008348; GO:0017025; GO:0017055; GO:0032502; GO:0035218; GO:0043388; GO:0045892 0 0 0 PF00505;PF09011; Q26481 CHOYP_LOC100203379.1.1 m.22430 sp RL5_STYCL 75.087 289 72 0 19 307 1 289 7.14E-160 450 RL5_STYCL reviewed 60S ribosomal protein L5 RPL5 Styela clava (Sea squirt) 295 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0008097 0 0 0 PF14204;PF17144; Q554E7 CHOYP_LOC752743.1.1 m.8353 sp ZDHC5_DICDI 25.537 419 290 11 61 473 159 561 7.14E-31 131 ZDHC5_DICDI reviewed Putative ZDHHC-type palmitoyltransferase 5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) DDB_G0275097 Dictyostelium discoideum (Slime mold) 751 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF12796;PF01529; Q58DL5 CHOYP_BCAR3.1.1 m.38415 sp BCAR3_BOVIN 38.776 343 194 5 553 889 487 819 7.14E-66 239 BCAR3_BOVIN reviewed Breast cancer anti-estrogen resistance protein 3 BCAR3 Bos taurus (Bovine) 826 small GTPase mediated signal transduction [GO:0007264] GO:0005085; GO:0005622; GO:0007264 0 0 0 PF00617;PF00017; Q60787 CHOYP_LCP2.3.14 m.8968 sp LCP2_MOUSE 36.885 122 74 2 580 698 402 523 7.14E-18 90.9 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q96RW7 CHOYP_HMCN1.26.44 m.45467 sp HMCN1_HUMAN 40.377 265 129 13 100 363 4576 4812 7.14E-55 199 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q99996 CHOYP_LOC100368547.36.40 m.59583 sp AKAP9_HUMAN 36.283 113 63 2 4 111 3579 3687 7.14E-11 61.6 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9D287 CHOYP_SPF27.1.1 m.37847 sp SPF27_MOUSE 71.338 157 45 0 1 157 15 171 7.14E-74 236 SPF27_MOUSE reviewed Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2 homolog) (DNA amplified in mammary carcinoma 1 protein) Bcas2 Dam1 Mus musculus (Mouse) 225 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0000974; GO:0005634; GO:0005662; GO:0005681; GO:0005730; GO:0030054; GO:0071011; GO:0071012; GO:0071013 0 0 0 PF05700; Q9SKK0 CHOYP_EBF1.1.1 m.55771 sp EBF1_ARATH 29.921 127 80 3 49 169 490 613 7.14E-06 52.4 EBF1_ARATH reviewed EIN3-binding F-box protein 1 (F-box/LRR-repeat protein 6) EBF1 FBL6 At2g25490 F13B15.15 Arabidopsis thaliana (Mouse-ear cress) 628 ethylene-activated signaling pathway [GO:0009873]; negative regulation of ethylene-activated signaling pathway [GO:0010105]; protein ubiquitination [GO:0016567]; response to ethylene [GO:0009723]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005634; GO:0006511; GO:0009723; GO:0009873; GO:0010105; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF13516; Q9V5N8 CHOYP_CDH23.2.2 m.44909 sp STAN_DROME 27.473 182 112 5 15 190 405 572 7.14E-11 63.9 STAN_DROME reviewed Protocadherin-like wing polarity protein stan (Protein flamingo) (Protein starry night) stan fmi CG11895 Drosophila melanogaster (Fruit fly) 3579 "axon guidance [GO:0007411]; axonogenesis [GO:0007409]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; dendrite development [GO:0016358]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of a polarized epithelium [GO:0001738]; mushroom body development [GO:0016319]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of Wnt signaling pathway [GO:0030178]; ommatidial rotation [GO:0016318]; positive regulation of axon extension [GO:0045773]; positive regulation of axon guidance [GO:1902669]; positive regulation of Wnt signaling pathway [GO:0030177]; R3/R4 cell fate commitment [GO:0007464]; R3/R4 development [GO:0048057]; regulation of axonogenesis [GO:0050770]; regulation of establishment of planar polarity [GO:0090175]; regulation of synapse assembly [GO:0051963]; regulation of tube length, open tracheal system [GO:0035159]; segment polarity determination [GO:0007367]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" GO:0001736; GO:0001738; GO:0004872; GO:0004888; GO:0004930; GO:0005057; GO:0005509; GO:0005887; GO:0005911; GO:0007156; GO:0007164; GO:0007165; GO:0007367; GO:0007409; GO:0007411; GO:0007464; GO:0016021; GO:0016055; GO:0016318; GO:0016319; GO:0016339; GO:0016358; GO:0019233; GO:0030177; GO:0030178; GO:0035159; GO:0042067; GO:0045746; GO:0045773; GO:0048057; GO:0048813; GO:0050770; GO:0050839; GO:0051963; GO:0070593; GO:0090175; GO:1902669 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; A6BM72 CHOYP_LOC100555755.1.1 m.58711 sp MEG11_HUMAN 34.729 406 236 17 4 400 467 852 7.15E-52 191 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; P48809 CHOYP_HRP28.1.1 m.22306 sp RB27C_DROME 54.128 109 43 2 12 113 97 205 7.15E-29 120 RB27C_DROME reviewed Heterogeneous nuclear ribonucleoprotein 27C (Hrb27-C) (HRP48.1) (hnRNP 48) Hrb27C hrp48 Rbp7 CG10377 Drosophila melanogaster (Fruit fly) 421 "axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; lateral inhibition [GO:0046331]; negative regulation of oskar mRNA translation [GO:0007319]; pole plasm oskar mRNA localization [GO:0045451]; positive regulation of translation [GO:0045727]; regulation of mRNA splicing, via spliceosome [GO:0048024]" GO:0000166; GO:0003697; GO:0003729; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0007298; GO:0007319; GO:0007411; GO:0030529; GO:0043186; GO:0043234; GO:0045451; GO:0045727; GO:0046331; GO:0048024; GO:0048027 0 0 0 PF00076; Q08379 CHOYP_LOC100492442.1.1 m.16466 sp GOGA2_HUMAN 32.865 925 515 16 10 848 13 917 7.15E-108 361 GOGA2_HUMAN reviewed Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95) GOLGA2 Homo sapiens (Human) 1002 asymmetric cell division [GO:0008356]; centrosome organization [GO:0051297]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; Golgi ribbon formation [GO:0090161]; microtubule nucleation [GO:0007020]; mitotic spindle assembly [GO:0090307]; negative regulation of autophagy [GO:0010507]; negative regulation of protein binding [GO:0032091]; positive regulation of protein glycosylation [GO:0060050]; protein glycosylation [GO:0006486]; protein homotetramerization [GO:0051289]; spindle assembly [GO:0051225]; spindle assembly involved in meiosis [GO:0090306] GO:0000137; GO:0000139; GO:0000922; GO:0005634; GO:0005794; GO:0005801; GO:0005874; GO:0005913; GO:0006486; GO:0006888; GO:0007020; GO:0008017; GO:0008356; GO:0010507; GO:0019901; GO:0019905; GO:0030134; GO:0032091; GO:0032580; GO:0033116; GO:0048208; GO:0051225; GO:0051289; GO:0051297; GO:0060050; GO:0061676; GO:0072686; GO:0090161; GO:0090166; GO:0090306; GO:0090307; GO:0098641 0 0 0 PF15070; Q14CN2 CHOYP_LOC100368604.1.1 m.3371 sp CLCA4_HUMAN 25.477 891 583 27 23 877 22 867 7.15E-72 258 CLCA4_HUMAN reviewed "Calcium-activated chloride channel regulator 4 (EC 3.4.-.-) (Calcium-activated chloride channel family member 4) (hCLCA4) (Calcium-activated chloride channel protein 2) (CaCC-2) (hCaCC-2) (Chloride channel accessory 4) [Cleaved into: Calcium-activated chloride channel regulator 4, 110 kDa form; Calcium-activated chloride channel regulator 4, 30 kDa form]" CLCA4 CaCC2 UNQ562/PRO1124 Homo sapiens (Human) 919 ion transmembrane transport [GO:0034220]; transport [GO:0006810] GO:0004222; GO:0005229; GO:0005254; GO:0005886; GO:0005887; GO:0006810; GO:0016324; GO:0034220; GO:0046872; GO:0070062 0 0 0 PF08434;PF00092; Q6P2H3 CHOYP_BRAFLDRAFT_122982.1.1 m.31726 sp CEP85_HUMAN 26.739 460 310 9 289 741 323 762 7.15E-38 154 CEP85_HUMAN reviewed Centrosomal protein of 85 kDa (Cep85) (Coiled-coil domain-containing protein 21) CEP85 CCDC21 Homo sapiens (Human) 762 chromosome segregation [GO:0007059]; negative regulation of protein kinase activity [GO:0006469]; regulation of mitotic centrosome separation [GO:0046602] GO:0000242; GO:0000922; GO:0005730; GO:0005737; GO:0005794; GO:0005813; GO:0006469; GO:0007059; GO:0046602 0 0 0 0 Q6R7G0 CHOYP_ABHV_ORF25.2.3 m.7912 sp Y068_OSHVF 18.78 623 423 13 24 573 25 637 7.15E-32 136 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6XLQ7 CHOYP_CALUB.2.2 m.58007 sp CALU_RABIT 61.61 323 112 8 7 325 1 315 7.15E-125 363 CALU_RABIT reviewed Calumenin CALU Oryctolagus cuniculus (Rabbit) 315 0 GO:0005509; GO:0005576; GO:0005789; GO:0005794; GO:0033018; GO:0042470 0 0 0 PF13202;PF13833; Q6ZRF8 CHOYP_LOC100374981.11.16 m.60884 sp RN207_HUMAN 20.976 205 147 6 6 208 103 294 7.15E-09 61.6 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8MZC4 CHOYP_SCHCODRAFT_76201.1.1 m.45881 sp CRLS1_DROME 46.766 201 107 0 86 286 120 320 7.15E-61 198 CRLS1_DROME reviewed Probable cardiolipin synthase (CMP-forming) (CLS) (EC 2.7.8.41) CLS CG4774 Drosophila melanogaster (Fruit fly) 322 ATP biosynthetic process [GO:0006754]; cardiolipin biosynthetic process [GO:0032049]; mitochondrial membrane organization [GO:0007006] GO:0005739; GO:0005743; GO:0006754; GO:0007006; GO:0008808; GO:0016021; GO:0032049 0 0 0 PF01066; Q8TDB6 CHOYP_LOC100555386.2.3 m.42291 sp DTX3L_HUMAN 53.514 185 85 1 377 561 556 739 7.15E-57 206 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q9IA76 CHOYP_LOC100180716.1.2 m.860 sp RL31_PAROL 72.727 110 30 0 52 161 13 122 7.15E-56 174 RL31_PAROL reviewed 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) 124 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00463; PF01198; Q9Y4G8 CHOYP_BRAFLDRAFT_131151.1.4 m.1430 sp RPGF2_HUMAN 58.389 298 118 2 191 482 67 364 7.15E-109 357 RPGF2_HUMAN reviewed Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) RAPGEF2 KIAA0313 NRAPGEP PDZGEF1 Homo sapiens (Human) 1499 adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; small GTPase mediated signal transduction [GO:0007264]; ventricular system development [GO:0021591] GO:0000165; GO:0001568; GO:0001764; GO:0004871; GO:0005088; GO:0005096; GO:0005509; GO:0005737; GO:0005770; GO:0005829; GO:0005886; GO:0005887; GO:0005911; GO:0005923; GO:0007186; GO:0007218; GO:0007264; GO:0008285; GO:0010976; GO:0016020; GO:0016324; GO:0017034; GO:0019933; GO:0019992; GO:0021591; GO:0021884; GO:0030033; GO:0030139; GO:0030165; GO:0030552; GO:0031175; GO:0031547; GO:0031697; GO:0032092; GO:0032486; GO:0035556; GO:0038180; GO:0043005; GO:0043025; GO:0043234; GO:0043547; GO:0043950; GO:0045202; GO:0045860; GO:0048022; GO:0048167; GO:0048471; GO:0050699; GO:0050774; GO:0061028; GO:0070300; GO:0070374; GO:0071320; GO:0071321; GO:0071880; GO:0072659; GO:0090557; GO:1901888; GO:1990090; GO:2000481; GO:2000670; GO:2001214; GO:2001224 0 0 cd06224; PF00595;PF00788;PF00617;PF00618; A6H6X4 CHOYP_BRAFLDRAFT_91435.1.1 m.14793 sp KCTD4_BOVIN 39.815 108 65 0 46 153 31 138 7.16E-21 89.7 KCTD4_BOVIN reviewed BTB/POZ domain-containing protein KCTD4 KCTD4 Bos taurus (Bovine) 259 protein homooligomerization [GO:0051260] GO:0051260 0 0 0 PF02214; A6NMZ7 CHOYP_GLNA2.4.4 m.64444 sp CO6A6_HUMAN 25.103 243 162 6 5 242 435 662 7.16E-19 89.7 CO6A6_HUMAN reviewed Collagen alpha-6(VI) chain COL6A6 Homo sapiens (Human) 2263 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030574 0 0 0 PF01391;PF00092; B3STU3 CHOYP_CHAC1.2.3 m.31924 sp CHAC1_RAT 42.784 194 101 4 13 204 31 216 7.16E-48 160 CHAC1_RAT reviewed Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 2.3.2.-) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1) (Neuroprotective protein 7) Chac1 Botch Npg7 Rattus norvegicus (Rat) 222 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein processing [GO:0010955]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; response to unfolded protein [GO:0006986] GO:0005112; GO:0005802; GO:0005829; GO:0006986; GO:0007219; GO:0010955; GO:0016746; GO:0022008; GO:0045746; GO:0070059 0 0 cd06661; PF04752; O02228 CHOYP_LOC100375425.1.1 m.7316 sp SC5A7_CAEEL 67.808 146 39 1 5 142 4 149 7.16E-63 204 SC5A7_CAEEL reviewed High-affinity choline transporter 1 cho-1 C48D1.3 Caenorhabditis elegans 576 acetylcholine biosynthetic process [GO:0008292]; choline transport [GO:0015871] GO:0005307; GO:0005887; GO:0008021; GO:0008292; GO:0015220; GO:0015871; GO:0030424; GO:0033265; GO:0043005; GO:0043025; GO:0045202 0 0 0 PF00474; P04069 CHOYP_NEMVEDRAFT_V1G182319.1.1 m.5050 sp CBPB_ASTAS 40.741 108 60 3 1 105 116 222 7.16E-25 99 CBPB_ASTAS reviewed Carboxypeptidase B (EC 3.4.17.2) 0 Astacus astacus (Noble crayfish) (Astacus fluviatilis) 303 0 GO:0004181; GO:0005576; GO:0008270 0 0 0 PF00246; P34456 CHOYP_LOC583562.1.1 m.18029 sp YMD2_CAEEL 22.193 374 267 13 22 383 1 362 7.16E-18 88.2 YMD2_CAEEL reviewed Uncharacterized protein F54H12.2 F54H12.2 Caenorhabditis elegans 419 deoxyribonucleotide biosynthetic process [GO:0009263] GO:0004748; GO:0005971; GO:0009263 0 0 0 0 P35555 CHOYP_ISCW_ISCW021545.1.1 m.25379 sp FBN1_HUMAN 36.649 382 228 6 1 377 2470 2842 7.16E-72 248 FBN1_HUMAN reviewed Fibrillin-1 [Cleaved into: Asprosin] FBN1 FBN Homo sapiens (Human) 2871 activation of protein kinase A activity [GO:0034199]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; protein kinase A signaling [GO:0010737]; regulation of cellular response to growth factor stimulus [GO:0090287]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501] GO:0001501; GO:0001527; GO:0001656; GO:0005178; GO:0005179; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0005604; GO:0005615; GO:0005622; GO:0006006; GO:0007507; GO:0008201; GO:0010737; GO:0022617; GO:0030023; GO:0030198; GO:0031012; GO:0032403; GO:0033627; GO:0034199; GO:0035582; GO:0035583; GO:0042593; GO:0043010; GO:0045671; GO:0048048; GO:0048050; GO:0070062; GO:0071560; GO:0090287; GO:1990314; GO:2001205 0 0 0 PF12662;PF07645;PF00683; P56592 CHOYP_CP1A2.1.1 m.37017 sp CP1A2_CANLF 43.82 178 97 2 20 196 306 481 7.16E-44 156 CP1A2_CANLF reviewed Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P450-D2) (DAH2) CYP1A2 Canis lupus familiaris (Dog) (Canis familiaris) 512 steroid metabolic process [GO:0008202] GO:0004497; GO:0005506; GO:0005789; GO:0008202; GO:0020037; GO:0031090; GO:0043231; GO:0070330 0 0 0 PF00067; P87498 CHOYP_LOC100376142.1.1 m.18172 sp VIT1_CHICK 24.465 327 203 9 39 350 1583 1880 7.16E-15 79.7 VIT1_CHICK reviewed Vitellogenin-1 (Minor vitellogenin) (Vitellogenin I) [Cleaved into: Lipovitellin-1 (Lipovitellin I) (LVI); Phosvitin (PV); Lipovitellin-2 (Lipovitellin II) (LVII); YGP42] VTG1 VTGI Gallus gallus (Chicken) 1912 0 GO:0005319; GO:0045735 0 0 0 PF09172;PF09175;PF01347;PF00094; Q62902 CHOYP_LOC660183.1.1 m.8143 sp LMAN1_RAT 38.802 384 208 7 1 374 151 517 7.16E-89 280 LMAN1_RAT reviewed Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Lectin mannose-binding 1) (p58) Lman1 Ergic53 Rattus norvegicus (Rat) 517 ER to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031] GO:0000139; GO:0005509; GO:0005537; GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0006888; GO:0015031; GO:0016021; GO:0033116; GO:0042802; GO:0043231 0 0 0 PF03388; Q68Y56 CHOYP_TLR7.2.2 m.55888 sp TLR4_PIG 26.106 452 275 18 425 846 396 818 7.16E-29 127 TLR4_PIG reviewed Toll-like receptor 4 (CD antigen CD284) TLR4 Sus scrofa (Pig) 841 defense response to Gram-negative bacterium [GO:0050829]; detection of lipopolysaccharide [GO:0032497]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224] GO:0001530; GO:0001875; GO:0002224; GO:0002755; GO:0004888; GO:0005887; GO:0006954; GO:0032497; GO:0034142; GO:0042116; GO:0045087; GO:0046696; GO:0050702; GO:0050707; GO:0050829; GO:1900227 0 0 0 PF13855;PF01582; Q6TFL4 CHOYP_KLH24.5.6 m.60669 sp KLH24_HUMAN 30.838 561 362 9 23 571 44 590 7.16E-85 279 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q7RTX9 CHOYP_BRAFLDRAFT_92063.2.2 m.33485 sp MOT14_HUMAN 33.73 252 165 1 35 286 1 250 7.16E-45 166 MOT14_HUMAN reviewed Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) 510 0 GO:0005886; GO:0008028; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q8BX80 CHOYP_ENGASE.1.1 m.54655 sp ENASE_MOUSE 41.23 553 301 12 6 547 79 618 7.16E-130 401 ENASE_MOUSE reviewed Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96) Engase Mus musculus (Mouse) 734 protein deglycosylation [GO:0006517] GO:0005829; GO:0006517; GO:0033925 0 0 0 PF03644; Q8TF01 CHOYP_PNISR.1.1 m.23159 sp PNISR_HUMAN 36.383 481 203 20 1 415 1 444 7.16E-43 171 PNISR_HUMAN reviewed "Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18)" PNISR C6orf111 SFRS18 SRRP130 HSPC261 HSPC306 Homo sapiens (Human) 805 0 GO:0005654; GO:0005737; GO:0016607; GO:0044822 0 0 0 PF15996; Q9CQE3 CHOYP_LOC101071902.1.1 m.49967 sp RT17_MOUSE 33.663 101 65 1 39 137 7 107 7.16E-11 60.5 RT17_MOUSE reviewed "28S ribosomal protein S17, mitochondrial (MRP-S17) (S17mt)" Mrps17 Rpms17 Mus musculus (Mouse) 120 mitochondrial translation [GO:0032543] GO:0003735; GO:0005739; GO:0005763; GO:0019843; GO:0032543 0 0 0 PF00366; Q9VBW3 CHOYP_FGFR4.1.1 m.8898 sp CAD96_DROME 48.829 299 152 1 653 950 464 762 7.16E-88 301 CAD96_DROME reviewed Tyrosine kinase receptor Cad96Ca (EC 2.7.10.1) (Cadherin-96Ca) (Tyrosine kinase receptor HD-14) Cad96Ca HD-14 CG10244 Drosophila melanogaster (Fruit fly) 773 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; Golgi organization [GO:0007030]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell size [GO:0045792]; positive regulation of wound healing [GO:0090303]; protein phosphorylation [GO:0006468]; wound healing [GO:0042060] GO:0004672; GO:0004713; GO:0004714; GO:0005509; GO:0005524; GO:0005887; GO:0006468; GO:0007030; GO:0007156; GO:0016339; GO:0042060; GO:0045177; GO:0045792; GO:0090303 0 0 0 PF07714; A2TF48 CHOYP_MYD88.7.7 m.66459 sp MYD88_PIG 33.582 134 84 3 6 136 156 287 7.17E-19 84.7 MYD88_PIG reviewed Myeloid differentiation primary response protein MyD88 MYD88 Sus scrofa (Pig) 293 defense response to Gram-positive bacterium [GO:0050830]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0002755; GO:0005737; GO:0006954; GO:0043123; GO:0045087; GO:0050830 0 0 0 PF00531;PF01582; A5PK00 CHOYP_VPS36.1.1 m.27030 sp VPS36_BOVIN 56.104 385 162 3 1 378 1 385 7.17E-159 454 VPS36_BOVIN reviewed Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36) VPS36 Bos taurus (Bovine) 386 "protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000814; GO:0005634; GO:0005768; GO:0006351; GO:0006355; GO:0031902; GO:0032266; GO:0043130; GO:0043328 0 0 0 PF04157;PF11605; F1M3L7 CHOYP_ISCW_ISCW018106.1.1 m.58146 sp EPS8_RAT 29.457 645 333 23 36 634 17 585 7.17E-63 226 EPS8_RAT reviewed Epidermal growth factor receptor kinase substrate 8 Eps8 Rattus norvegicus (Rat) 822 actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360] GO:0003779; GO:0005903; GO:0005938; GO:0008344; GO:0008360; GO:0010458; GO:0014069; GO:0016601; GO:0017146; GO:0030054; GO:0030426; GO:0030832; GO:0031532; GO:0032420; GO:0032587; GO:0035591; GO:0036336; GO:0048149; GO:0048365; GO:0051016; GO:0051017; GO:0051764; GO:0070062; GO:0070358 0 0 0 PF08416;PF00018; F1MNN4 CHOYP_BRAFLDRAFT_83410.1.1 m.28613 sp FBXW7_BOVIN 29.841 439 262 11 15 437 204 612 7.17E-56 198 FBXW7_BOVIN reviewed F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) FBXW7 FBW7 Bos taurus (Bovine) 627 cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; negative regulation of DNA endoreduplication [GO:0032876]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903378]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; regulation of mitophagy [GO:1903146]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; sister chromatid cohesion [GO:0007062] GO:0005654; GO:0005730; GO:0005737; GO:0006974; GO:0007062; GO:0016567; GO:0019005; GO:0031146; GO:0032876; GO:0034644; GO:0045741; GO:0050816; GO:0050821; GO:0051443; GO:0070374; GO:0097027; GO:1901800; GO:1903146; GO:1903378; GO:1903955; GO:1990452; GO:2000060 0 0 0 PF12937;PF00400; O15050 CHOYP_TRANK1.5.9 m.33113 sp TRNK1_HUMAN 27.766 461 280 14 1292 1718 423 864 7.17E-31 137 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O34309 CHOYP_LOC100890479.3.3 m.53015 sp PPS_BACSU 33.742 163 87 5 80 233 238 388 7.17E-16 84.3 PPS_BACSU reviewed "Putative phosphoenolpyruvate synthase (Putative PEP synthase) (Pyruvate, water dikinase)" pps BSU18830 Bacillus subtilis (strain 168) 866 0 GO:0005524; GO:0016301 0 0 0 PF00391;PF01326; O70277 CHOYP_BRAFLDRAFT_69798.13.22 m.46260 sp TRIM3_RAT 27.481 131 87 4 17 140 614 743 7.17E-07 51.6 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O97562 CHOYP_UCP1.1.1 m.39300 sp UCP2_PIG 49.682 314 145 3 21 328 2 308 7.17E-107 318 UCP2_PIG reviewed Mitochondrial uncoupling protein 2 (UCP 2) (Solute carrier family 25 member 8) UCP2 SLC25A8 Sus scrofa (Pig) 309 mitochondrial transport [GO:0006839]; regulation of mitochondrial membrane potential [GO:0051881]; response to hypoxia [GO:0001666]; translation [GO:0006412] GO:0001666; GO:0003735; GO:0005743; GO:0006412; GO:0006839; GO:0016021; GO:0051881 0 0 0 PF00153; Q01177 CHOYP_PLMN.5.11 m.35532 sp PLMN_RAT 38.386 508 218 18 203 652 90 560 7.17E-86 289 PLMN_RAT reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]" Plg Rattus norvegicus (Rat) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; labyrinthine layer blood vessel development [GO:0060716]; mononuclear cell migration [GO:0071674]; muscle cell cellular homeostasis [GO:0046716]; myoblast differentiation [GO:0045445]; proteolysis involved in cellular protein catabolic process [GO:0051603]; tissue regeneration [GO:0042246]; tissue remodeling [GO:0048771]; trophoblast giant cell differentiation [GO:0060707] GO:0004175; GO:0004252; GO:0005576; GO:0005886; GO:0007596; GO:0019897; GO:0042246; GO:0042730; GO:0043231; GO:0045445; GO:0046716; GO:0048771; GO:0051603; GO:0060707; GO:0060716; GO:0071674 0 0 cd00190; PF00051;PF00024;PF00089; Q16629 CHOYP_PHUM_PHUM241330.1.3 m.29132 sp SRSF7_HUMAN 64.8 125 38 2 1 125 1 119 7.17E-47 155 SRSF7_HUMAN reviewed "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) 238 "mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000166; GO:0000398; GO:0005634; GO:0005654; GO:0005737; GO:0006369; GO:0006397; GO:0006405; GO:0006406; GO:0008270; GO:0008380; GO:0031124; GO:0044822; GO:0048025; GO:0070062 0 0 0 PF00076; Q16629 CHOYP_PHUM_PHUM241330.2.3 m.58965 sp SRSF7_HUMAN 64.8 125 38 2 1 125 1 119 7.17E-47 155 SRSF7_HUMAN reviewed "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) 238 "mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000166; GO:0000398; GO:0005634; GO:0005654; GO:0005737; GO:0006369; GO:0006397; GO:0006405; GO:0006406; GO:0008270; GO:0008380; GO:0031124; GO:0044822; GO:0048025; GO:0070062 0 0 0 PF00076; Q3MHR7 CHOYP_TEN2.1.2 m.44822 sp ARPC2_BOVIN 75.333 300 74 0 1 300 1 300 7.17E-176 491 ARPC2_BOVIN reviewed Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) ARPC2 Bos taurus (Bovine) 300 Arp2/3 complex-mediated actin nucleation [GO:0034314]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026] GO:0005200; GO:0005768; GO:0005794; GO:0005829; GO:0005885; GO:0005925; GO:0010592; GO:0031252; GO:0034314; GO:0036195; GO:0043005; GO:0045202; GO:0070062; GO:1900026 0 0 0 PF04045; Q5U3I2 CHOYP_LOC100117732.1.1 m.18588 sp S7A6O_DANRE 24.922 321 178 7 6 318 6 271 7.17E-10 63.2 S7A6O_DANRE reviewed Probable RNA polymerase II nuclear localization protein SLC7A6OS (Solute carrier family 7 member 6 opposite strand transcript homolog) slc7a6os zgc:103493 Danio rerio (Zebrafish) (Brachydanio rerio) 326 central nervous system development [GO:0007417]; midbrain-hindbrain boundary structural organization [GO:0021552]; protein transport [GO:0015031]; somite development [GO:0061053] GO:0005634; GO:0005737; GO:0007417; GO:0015031; GO:0021552; GO:0061053 0 0 0 PF08574; Q9NQ86 CHOYP_LOC100376215.6.19 m.32430 sp TRI36_HUMAN 22.059 340 233 11 7 328 151 476 7.17E-09 61.2 TRI36_HUMAN reviewed E3 ubiquitin-protein ligase TRIM36 (EC 6.3.2.-) (RING finger protein 98) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) TRIM36 RBCC728 RNF98 Homo sapiens (Human) 728 acrosome reaction [GO:0007340]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726] GO:0000209; GO:0001669; GO:0004842; GO:0005829; GO:0005856; GO:0007340; GO:0008270; GO:0016874; GO:0051726; GO:0070062 0 0 0 PF00041;PF00643;PF13445; Q9NXS3 CHOYP_LOC100186276.3.5 m.12158 sp KLH28_HUMAN 29.231 130 88 3 10 136 14 142 7.17E-08 59.7 KLH28_HUMAN reviewed Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) 571 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0031463; GO:0042787 0 0 0 PF07707;PF00651;PF01344; A2AJ76 CHOYP_HMCN2.5.12 m.28983 sp HMCN2_MOUSE 25.316 2054 1271 84 49 2041 622 2473 7.18E-99 362 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; B0BML7 CHOYP_SPR.1.3 m.17978 sp SPRE_XENTR 36.111 252 153 3 27 275 13 259 7.18E-51 171 SPRE_XENTR reviewed Sepiapterin reductase (SPR) (EC 1.1.1.153) spr Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 261 tetrahydrobiopterin biosynthetic process [GO:0006729] GO:0004757; GO:0005737; GO:0006729 0 0 0 PF00106; O75179 CHOYP_ANK1.1.8 m.45 sp ANR17_HUMAN 42.857 105 56 3 3 105 541 643 7.18E-15 72 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P05450 CHOYP_BRAFLDRAFT_67193.2.3 m.36263 sp YAT7_RHOBL 40.625 64 36 1 107 170 39 100 7.18E-08 52.4 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P11143 CHOYP_HSP7C.2.2 m.28029 sp HSP70_MAIZE 37.748 151 91 2 29 179 382 529 7.18E-24 102 HSP70_MAIZE reviewed Heat shock 70 kDa protein HSP70 Zea mays (Maize) 645 0 GO:0005524 0 0 0 PF00012; P30044 CHOYP_BRAFLDRAFT_119799.1.1 m.23765 sp PRDX5_HUMAN 59.524 168 66 1 18 183 43 210 7.18E-69 211 PRDX5_HUMAN reviewed "Peroxiredoxin-5, mitochondrial (EC 1.11.1.15) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin reductase)" PRDX5 ACR1 SBBI10 Homo sapiens (Human) 214 cell redox homeostasis [GO:0045454]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; inflammatory response [GO:0006954]; NADPH oxidation [GO:0070995]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of transcription from RNA polymerase III promoter [GO:0016480]; positive regulation of collagen biosynthetic process [GO:0032967]; reactive nitrogen species metabolic process [GO:2001057]; regulation of apoptosis involved in tissue homeostasis [GO:0060785]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302] GO:0000302; GO:0001016; GO:0004601; GO:0005102; GO:0005615; GO:0005634; GO:0005737; GO:0005739; GO:0005759; GO:0005777; GO:0005782; GO:0005829; GO:0006954; GO:0006979; GO:0008379; GO:0016209; GO:0016480; GO:0031410; GO:0032967; GO:0034614; GO:0042744; GO:0043027; GO:0043066; GO:0043231; GO:0045454; GO:0046983; GO:0048471; GO:0051354; GO:0051920; GO:0060785; GO:0070062; GO:0070995; GO:0072541; GO:2001057 0 0 0 PF08534; P41042 CHOYP_BRAFLDRAFT_215239.2.3 m.22663 sp RS4_DROME 80.808 99 19 0 2 100 162 260 7.18E-54 171 RS4_DROME reviewed 40S ribosomal protein S4 RpS4 RP4 CG11276 Drosophila melanogaster (Fruit fly) 261 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0007052; GO:0019843; GO:0022627; GO:0051297; GO:0051298 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; P41042 CHOYP_RS4.5.11 m.30052 sp RS4_DROME 80.808 99 19 0 2 100 162 260 7.18E-54 171 RS4_DROME reviewed 40S ribosomal protein S4 RpS4 RP4 CG11276 Drosophila melanogaster (Fruit fly) 261 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0007052; GO:0019843; GO:0022627; GO:0051297; GO:0051298 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; P48166 CHOYP_NEMVEDRAFT_V1G235042.1.2 m.30122 sp RL36A_CAEEL 83.696 92 15 0 69 160 14 105 7.18E-49 155 RL36A_CAEEL reviewed Ribosomal protein L36.A (60S ribosomal protein L44) (L41) rpl-36.A rpl-41 C09H10.2 Caenorhabditis elegans 105 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00935; P70583 CHOYP_LOC100557203.1.1 m.66114 sp DUT_RAT 69.065 139 43 0 11 149 67 205 7.18E-69 209 DUT_RAT reviewed Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (PPAR-interacting protein 4) (PIP4) (dUTP pyrophosphatase) Dut Dutp Rattus norvegicus (Rat) 205 dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; liver development [GO:0001889]; protein homotrimerization [GO:0070207]; regulation of protein heterodimerization activity [GO:0043497]; response to organic cyclic compound [GO:0014070] GO:0000287; GO:0001889; GO:0004170; GO:0005634; GO:0005737; GO:0005829; GO:0006226; GO:0014070; GO:0030547; GO:0032556; GO:0042975; GO:0043497; GO:0046081; GO:0070207 PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. 0 cd07557; PF00692; P84239 CHOYP_H3.1.2 m.3829 sp H3_URECA 100 113 0 0 1 113 24 136 7.18E-79 231 H3_URECA reviewed Histone H3 0 Urechis caupo (Innkeeper worm) (Spoonworm) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q07954 CHOYP_CBG11882.1.2 m.12049 sp LRP1_HUMAN 36.29 124 63 3 348 469 820 929 7.18E-14 78.6 LRP1_HUMAN reviewed Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] LRP1 A2MR APR Homo sapiens (Human) 4544 aging [GO:0007568]; aorta morphogenesis [GO:0035909]; apoptotic cell clearance [GO:0043277]; beta-amyloid clearance [GO:0097242]; cell proliferation [GO:0008283]; cerebral cortex development [GO:0021987]; lipoprotein metabolic process [GO:0042157]; lipoprotein transport [GO:0042953]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of neuron projection development [GO:0010977]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of lipid transport [GO:0032370]; positive regulation of protein transport [GO:0051222]; protein kinase C-activating G-protein coupled receptor signaling pathway [GO:0007205]; receptor-mediated endocytosis [GO:0006898]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cholesterol transport [GO:0032374]; regulation of phospholipase A2 activity [GO:0032429]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0004872; GO:0005041; GO:0005509; GO:0005730; GO:0005737; GO:0005765; GO:0005768; GO:0005886; GO:0005887; GO:0005905; GO:0005925; GO:0006898; GO:0007205; GO:0007568; GO:0008283; GO:0010875; GO:0010977; GO:0014912; GO:0021987; GO:0030136; GO:0030178; GO:0030425; GO:0030666; GO:0032370; GO:0032374; GO:0032403; GO:0032429; GO:0032956; GO:0034185; GO:0035909; GO:0042157; GO:0042953; GO:0042954; GO:0043025; GO:0043235; GO:0043277; GO:0043524; GO:0044822; GO:0051222; GO:0070325; GO:0097242; GO:2000587 0 0 0 PF12662;PF16472;PF07645;PF00057;PF00058; Q26065 CHOYP_ACT.27.27 m.66539 sp ACT_PLAMG 92.857 126 9 0 2 127 217 342 7.18E-79 241 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q86Y13 CHOYP_NEMVEDRAFT_V1G247590.13.13 m.66516 sp DZIP3_HUMAN 30.588 85 54 2 79 161 459 540 7.18E-06 49.7 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8K2F8 CHOYP_LOC101071011.1.1 m.18617 sp LS14A_MOUSE 39.623 159 58 7 3 129 303 455 7.18E-17 79 LS14A_MOUSE reviewed Protein LSM14 homolog A (Protein FAM61A) (RNA-associated protein 55A) (mRAP55A) Lsm14a Fam61a Rap55a Mus musculus (Mouse) 462 cytoplasmic mRNA processing body assembly [GO:0033962]; defense response to virus [GO:0051607]; multicellular organism development [GO:0007275]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of translation [GO:0006417]; RIG-I signaling pathway [GO:0039529] GO:0000932; GO:0003690; GO:0003725; GO:0003727; GO:0005737; GO:0006417; GO:0007275; GO:0010494; GO:0033962; GO:0039529; GO:0043231; GO:0044822; GO:0051607; GO:0060340 0 0 0 PF09532;PF12701; Q9D0R2 CHOYP_BRAFLDRAFT_268618.1.1 m.19813 sp SYTC_MOUSE 55.556 99 44 0 1 99 624 722 7.18E-32 120 SYTC_MOUSE reviewed "Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS)" Tars Mus musculus (Mouse) 722 threonyl-tRNA aminoacylation [GO:0006435] GO:0003723; GO:0004829; GO:0005524; GO:0005737; GO:0006435; GO:0015629; GO:0070062 0 0 cd00771; PF03129;PF02824;PF00587;PF07973; Q9H553 CHOYP_BRAFLDRAFT_70178.1.1 m.59184 sp ALG2_HUMAN 58.065 403 153 6 4 395 17 414 7.18E-161 462 ALG2_HUMAN reviewed "Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (Asparagine-linked glycosylation protein 2 homolog) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) (GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) (GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)" ALG2 UNQ666/PRO1298 Homo sapiens (Human) 416 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation in endoplasmic reticulum [GO:0033577]; response to calcium ion [GO:0051592] GO:0000033; GO:0004378; GO:0005634; GO:0005737; GO:0005789; GO:0006488; GO:0016020; GO:0016021; GO:0033577; GO:0046982; GO:0047485; GO:0048306; GO:0048471; GO:0051592 PATHWAY: Protein modification; protein glycosylation. 0 0 PF13439;PF00534; Q9MYM7 CHOYP_BM_BRE5.1.2 m.10586 sp B3GT1_PONPY 33.065 248 154 5 87 327 45 287 7.18E-36 136 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9V5L3 CHOYP_LOC100376649.3.4 m.47647 sp C49A1_DROME 30.095 525 298 17 5 490 78 572 7.18E-61 213 C49A1_DROME reviewed Probable cytochrome P450 49a1 (EC 1.14.-.-) (CYPXLIXA1) Cyp49a1 CG18377 Drosophila melanogaster (Fruit fly) 589 0 GO:0004497; GO:0005506; GO:0005789; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; A6QLA0 CHOYP_NFX1.2.2 m.63447 sp NFX1_BOVIN 40.909 66 39 0 1 66 471 536 7.19E-12 64.3 NFX1_BOVIN reviewed "Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding protein 1)" NFX1 Bos taurus (Bovine) 1116 negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0000977; GO:0001078; GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006366; GO:0008270; GO:0016874; GO:0044822; GO:0045347 0 0 0 PF01424;PF01422; O00124 CHOYP_LOC100368461.1.1 m.58339 sp UBXN8_HUMAN 31.579 190 127 3 112 299 79 267 7.19E-19 87.4 UBXN8_HUMAN reviewed UBX domain-containing protein 8 (Reproduction 8 protein) (Rep-8 protein) (UBX domain-containing protein 6) UBXN8 D8S2298E REP8 UBXD6 Homo sapiens (Human) 270 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; single fertilization [GO:0007338] GO:0007338; GO:0030176; GO:0030433 0 0 0 PF00789; O14522 CHOYP_PTPRT.22.45 m.47112 sp PTPRT_HUMAN 32.131 610 375 9 216 788 688 1295 7.19E-87 305 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; P10079 CHOYP_LOC100634060.22.37 m.47536 sp FBP1_STRPU 50.287 348 173 0 298 645 211 558 7.19E-104 342 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P10394 CHOYP_LOC100707942.1.2 m.19039 sp POL4_DROME 25.926 351 245 7 2 346 893 1234 7.19E-30 125 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P10792 CHOYP_SOD3.1.1 m.6389 sp SODCP_PETHY 44 150 74 4 125 274 78 217 7.19E-30 116 SODCP_PETHY reviewed "Superoxide dismutase [Cu-Zn], chloroplastic (EC 1.15.1.1)" SODCP Petunia hybrida (Petunia) 219 cellular response to high light intensity [GO:0071486] GO:0004784; GO:0009507; GO:0046872; GO:0071486 0 0 cd00305; PF00080; P54316 CHOYP_BRAFLDRAFT_126555.3.6 m.26765 sp LIPR1_RAT 32.438 484 293 11 20 489 1 464 7.19E-74 244 LIPR1_RAT reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) Pnliprp1 Plrp1 Rattus norvegicus (Rat) 473 lipid metabolic process [GO:0006629]; pancreas development [GO:0031016]; response to glucocorticoid [GO:0051384]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005509; GO:0005615; GO:0006629; GO:0016298; GO:0031016; GO:0043434; GO:0051384 0 0 0 PF00151;PF01477; Q4A3R3 CHOYP_DMBT1.33.34 m.60127 sp DMBT1_PIG 36.842 380 166 9 2 374 167 479 7.19E-56 205 DMBT1_PIG reviewed Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) 1204 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0007275; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0035375; GO:0042589 0 0 0 PF00431;PF00530;PF00100; Q63504 CHOYP_NR1D2.1.2 m.34244 sp NR1D2_RAT 27.197 478 266 14 83 484 103 574 7.19E-34 138 NR1D2_RAT reviewed Nuclear receptor subfamily 1 group D member 2 (EAR4) (Rev-erb-beta) Nr1d2 Rattus norvegicus (Rat) 578 "lipid homeostasis [GO:0055088]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; regulation of energy homeostasis [GO:2000505]; regulation of inflammatory response [GO:0050727]; regulation of lipid metabolic process [GO:0019216]; regulation of skeletal muscle cell differentiation [GO:2001014]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0001046; GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0019216; GO:0042752; GO:0045892; GO:0045893; GO:0048511; GO:0050727; GO:0055088; GO:2000505; GO:2001014 0 0 0 PF00104;PF00105; Q6UX40 CHOYP_ISCW_ISCW012049.1.1 m.30297 sp TM107_HUMAN 54.615 130 59 0 2 131 3 132 7.19E-52 164 TM107_HUMAN reviewed Transmembrane protein 107 TMEM107 DC20 UNQ638/PRO1268 Homo sapiens (Human) 140 cilium assembly [GO:0042384]; embryonic digit morphogenesis [GO:0042733]; neural tube patterning [GO:0021532]; nonmotile primary cilium assembly [GO:0035058] GO:0016021; GO:0021532; GO:0035058; GO:0035869; GO:0042384; GO:0042733 0 0 0 PF14995; Q9HC56 CHOYP_PCDH9.1.5 m.6421 sp PCDH9_HUMAN 32.503 763 486 13 6 748 8 761 7.19E-119 397 PCDH9_HUMAN reviewed Protocadherin-9 PCDH9 Homo sapiens (Human) 1237 forebrain development [GO:0030900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021; GO:0030426; GO:0030900; GO:0044291 0 0 0 PF00028;PF08266;PF08374; Q9HCB6 CHOYP_DGRI_GH22804.1.1 m.12160 sp SPON1_HUMAN 31.191 747 397 23 58 785 72 720 7.19E-101 333 SPON1_HUMAN reviewed Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor) SPON1 KIAA0762 VSGP Homo sapiens (Human) 807 cell adhesion [GO:0007155]; protein O-linked fucosylation [GO:0036066] GO:0005578; GO:0005615; GO:0005788; GO:0007155; GO:0036066; GO:0046872 0 0 cd08544; PF02014;PF06468;PF00090; Q9PTU1 CHOYP_DBX1.1.1 m.26938 sp DBX1A_DANRE 44.839 310 96 12 1 274 2 272 7.19E-62 202 DBX1A_DANRE reviewed Homeobox protein DBX1-A (Developing brain homeobox protein 1-A) (Homeobox protein hlx1) dbx1a hlx1 Danio rerio (Zebrafish) (Brachydanio rerio) 314 "cell differentiation in spinal cord [GO:0021515]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0021515; GO:0043565 0 0 0 PF00046; Q9R1R2 CHOYP_LOC100376608.2.4 m.47059 sp TRIM3_MOUSE 20.187 535 335 13 57 550 110 593 7.19E-14 78.2 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_87293.3.3 m.32662 sp TRIM2_BOVIN 28.814 118 79 3 22 134 627 744 7.20E-08 53.1 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O01761 CHOYP_LOC100367089.2.4 m.1912 sp UNC89_CAEEL 24.18 976 584 30 80 986 5171 6059 7.20E-57 219 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O70277 CHOYP_LOC100374342.19.19 m.65064 sp TRIM3_RAT 26.147 218 138 9 283 493 506 707 7.20E-08 58.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P68827 CHOYP_LOC100374624.1.1 m.48991 sp NAGPA_BOVIN 45.263 380 183 7 75 446 35 397 7.20E-105 324 NAGPA_BOVIN reviewed N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) NAGPA Bos taurus (Bovine) 527 protein glycosylation [GO:0006486] GO:0003944; GO:0006486; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF09992; Q07G17 CHOYP_LOC100874646.1.1 m.15691 sp PCGF3_XENTR 52.917 240 90 4 20 238 1 238 7.20E-84 253 PCGF3_XENTR reviewed Polycomb group RING finger protein 3 pcgf3 TNeu137d10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 242 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0008270; GO:0031519 0 0 0 PF16207; Q3UGY8 CHOYP_LOC408471.1.1 m.46732 sp BIG3_MOUSE 37.8 791 419 20 460 1206 660 1421 7.20E-140 477 BIG3_MOUSE reviewed Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) Arfgef3 Big3 D10Bwg1379e Kiaa1244 Mus musculus (Mouse) 2170 negative regulation of phosphatase activity [GO:0010923]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0010923; GO:0016021; GO:0030658; GO:0032012 0 0 0 PF16213;PF09324; Q505G8 CHOYP_SRYD.1.1 m.19076 sp ZN827_MOUSE 46.939 49 25 1 225 272 373 421 7.20E-07 53.9 ZN827_MOUSE reviewed Zinc finger protein 827 Znf827 Zfp827 Mus musculus (Mouse) 1078 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 Q59990 CHOYP_LOC100375098.1.1 m.65425 sp CP120_SYNY3 26.376 436 284 12 5 413 15 440 7.20E-29 120 CP120_SYNY3 reviewed Putative cytochrome P450 120 (EC 1.14.-.-) cyp120 cyp slr0574 Synechocystis sp. (strain PCC 6803 / Kazusa) 444 0 GO:0004497; GO:0005506; GO:0016705; GO:0020037 0 0 0 PF00067; Q5AT15 CHOYP_LOC100374280.1.1 m.17385 sp CYSA_EMENI 46.256 454 167 8 88 467 67 517 7.20E-130 389 CYSA_EMENI reviewed Serine O-acetyltransferase (EC 2.3.1.30) cysA AN8565 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 517 cysteine biosynthetic process [GO:0019344]; cysteine metabolic process [GO:0006534]; methionine biosynthetic process [GO:0009086] GO:0004414; GO:0005739; GO:0006534; GO:0009001; GO:0009086; GO:0016787; GO:0019344 PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2. {ECO:0000305|PubMed:11021945}. 0 0 PF00561; Q5EA79 CHOYP_OTER_1386.1.1 m.15303 sp GALM_BOVIN 49.415 342 168 5 47 387 5 342 7.20E-109 326 GALM_BOVIN reviewed Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) GALM Bos taurus (Bovine) 342 galactose metabolic process [GO:0006012]; glucose metabolic process [GO:0006006] GO:0004034; GO:0005737; GO:0006006; GO:0006012; GO:0030246; GO:0070062 PATHWAY: Carbohydrate metabolism; hexose metabolism. 0 0 PF01263; Q6P132 CHOYP_IQCA1.1.3 m.4289 sp TXB1B_DANRE 27.244 936 501 31 56 949 19 816 7.20E-68 246 TXB1B_DANRE reviewed Tax1-binding protein 1 homolog B tax1bp1b tax1bp1 zgc:77129 Danio rerio (Zebrafish) (Brachydanio rerio) 823 apoptotic process [GO:0006915] GO:0006915; GO:0046872 0 0 0 PF07888; Q86UK5 CHOYP_LOC100892888.1.1 m.33763 sp LBN_HUMAN 23.69 916 631 21 100 1000 167 1029 7.20E-39 162 LBN_HUMAN reviewed Limbin (Ellis-van Creveld syndrome protein 2) (EVC2) EVC2 LBN Homo sapiens (Human) 1308 smoothened signaling pathway [GO:0007224] GO:0005634; GO:0005737; GO:0005856; GO:0005929; GO:0007224; GO:0016021; GO:0060170 0 0 0 PF12297; Q95NQ0 CHOYP_PHUM_PHUM300610.5.5 m.43725 sp MTH2_DROSI 25.795 283 171 10 208 461 206 478 7.20E-14 77.4 MTH2_DROSI reviewed G-protein coupled receptor Mth2 (Protein methuselah-2) mth2 Drosophila simulans (Fruit fly) 536 cell surface receptor signaling pathway [GO:0007166]; response to stress [GO:0006950] GO:0004930; GO:0005886; GO:0006950; GO:0007166; GO:0016021 0 0 0 PF00002;PF06652; A1L162 CHOYP_LOC100893093.1.2 m.19425 sp ERIC2_HUMAN 44.565 92 49 2 169 260 64 153 7.21E-13 68.6 ERIC2_HUMAN reviewed Glutamate-rich protein 2 ERICH2 Homo sapiens (Human) 156 0 0 0 0 0 0 A4IGF3 CHOYP_LOC659910.1.1 m.8307 sp ATP23_DANRE 39.623 212 100 6 34 230 29 227 7.21E-40 141 ATP23_DANRE reviewed Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) atp23 xrcc6bp1 zgc:162885 Danio rerio (Zebrafish) (Brachydanio rerio) 254 0 GO:0004222; GO:0046872 0 0 0 PF09768; A5PMU4 CHOYP_CAOG_03834.1.1 m.56376 sp ANS1B_DANRE 31.973 294 181 8 1 286 1 283 7.21E-30 130 ANS1B_DANRE reviewed Ankyrin repeat and sterile alpha motif domain-containing protein 1B anks1b si:ch211-211o1.2 si:dkey-11k24.3 Danio rerio (Zebrafish) (Brachydanio rerio) 1280 regulation of synaptic plasticity by receptor localization to synapse [GO:1900383] GO:0005737; GO:1900383 0 0 0 PF12796;PF00640;PF00536;PF07647; E9QHE3 CHOYP_BRAFLDRAFT_117193.2.2 m.33636 sp RN207_DANRE 34.828 290 186 2 1 289 298 585 7.21E-46 172 RN207_DANRE reviewed RING finger protein 207 rnf207b rnf207 Danio rerio (Zebrafish) (Brachydanio rerio) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0005737; GO:0008270; GO:0055117; GO:0086019; GO:1901207; GO:1903762; GO:1903954 0 0 0 PF03915;PF00643; P97864 CHOYP_CASP7.11.23 m.26574 sp CASP7_MOUSE 44.771 306 152 4 6 301 4 302 7.21E-89 270 CASP7_MOUSE reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] Casp7 Lice2 Mch3 Mus musculus (Mouse) 303 aging [GO:0007568]; apoptotic process [GO:0006915]; execution phase of apoptosis [GO:0097194]; heart development [GO:0007507]; neuron apoptotic process [GO:0051402]; protein processing [GO:0016485]; proteolysis [GO:0006508]; response to UV [GO:0009411] GO:0004190; GO:0004197; GO:0005634; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0007507; GO:0007568; GO:0009411; GO:0016485; GO:0051402; GO:0097153; GO:0097194; GO:0097200 0 0 0 0 Q10651 CHOYP_A4.3.3 m.22263 sp A4_CAEEL 32.813 448 271 12 38 459 1 444 7.21E-65 229 A4_CAEEL reviewed Beta-amyloid-like protein apl-1 C42D8.8 Caenorhabditis elegans 686 "body morphogenesis [GO:0010171]; cell differentiation [GO:0030154]; ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; nematode larval development [GO:0002119]; nervous system development [GO:0007399]" GO:0002119; GO:0005769; GO:0007399; GO:0008201; GO:0010171; GO:0016021; GO:0030154; GO:0031410; GO:0042395; GO:0043005; GO:0043025; GO:0046914 0 0 0 PF10515;PF12924;PF12925;PF02177; Q2MKA5 CHOYP_ACHB3.4.5 m.64448 sp ACHA5_MOUSE 30.112 269 181 5 13 279 46 309 7.21E-26 112 ACHA5_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-5 Chrna5 Mus musculus (Mouse) 467 "behavioral response to nicotine [GO:0035095]; cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0015464; GO:0030054; GO:0030425; GO:0035094; GO:0035095; GO:0042166; GO:0043025; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; Q40588 CHOYP_LOC100376272.3.4 m.30521 sp ASO_TOBAC 28.83 607 328 17 146 733 45 566 7.21E-60 215 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q4FZG9 CHOYP_LOC581594.1.3 m.30608 sp NUA4L_MOUSE 38.806 67 40 1 42 107 11 77 7.21E-10 56.2 NUA4L_MOUSE reviewed NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 Ndufa4l2 Mus musculus (Mouse) 87 hydrogen ion transmembrane transport [GO:1902600] GO:0005751; GO:0008137; GO:1902600 0 0 0 PF06522; Q502M6 CHOYP_ACA1_388490.1.3 m.23339 sp ANR29_DANRE 36.111 180 115 0 4 183 59 238 7.21E-33 122 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q6GM59 CHOYP_SLC16A12.1.1 m.51088 sp MOT12_XENLA 26.852 432 275 7 12 413 12 432 7.21E-50 179 MOT12_XENLA reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 Xenopus laevis (African clawed frog) 460 creatine transmembrane transport [GO:1902598] GO:0005308; GO:0005887; GO:0015293; GO:1902598 0 0 cd06174; PF07690; Q6R798 CHOYP_Y118.1.1 m.30003 sp Y119_OSHVF 100 147 0 0 1 147 1 147 7.21E-108 308 Y119_OSHVF reviewed Uncharacterized protein ORF119 ORF119 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 192 0 0 0 0 0 0 Q8K0U4 CHOYP_HS12B.2.14 m.19896 sp HS12A_MOUSE 35.285 615 338 12 6 568 56 662 7.21E-108 341 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8NET8 CHOYP_BRAFLDRAFT_76035.1.1 m.48792 sp TRPV3_HUMAN 25.532 141 102 1 5 142 575 715 7.21E-08 56.6 TRPV3_HUMAN reviewed Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3) TRPV3 Homo sapiens (Human) 790 calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to heat [GO:0009408] GO:0005262; GO:0005886; GO:0005887; GO:0009408; GO:0042636; GO:0043235; GO:0070588; GO:0090280 0 0 0 PF12796;PF00520; Q96MM6 CHOYP_BRAFLDRAFT_208436.24.32 m.59663 sp HS12B_HUMAN 34.231 631 348 14 9 579 61 684 7.21E-120 372 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99572 CHOYP_LOC585718.1.2 m.37837 sp P2RX7_HUMAN 39.286 112 58 3 125 229 470 578 7.21E-16 79.3 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; Q9CY64 CHOYP_BLVRA.1.1 m.17904 sp BIEA_MOUSE 30.903 288 170 12 15 288 18 290 7.21E-28 112 BIEA_MOUSE reviewed Biliverdin reductase A (BVR A) (EC 1.3.1.24) (Biliverdin-IX alpha-reductase) Blvra Mus musculus (Mouse) 295 heme catabolic process [GO:0042167]; oxidation-reduction process [GO:0055114] GO:0000166; GO:0004074; GO:0005737; GO:0008270; GO:0042167; GO:0055114; GO:0070062 PATHWAY: Porphyrin-containing compound metabolism; protoheme degradation. 0 0 PF09166;PF01408; Q9JI03 CHOYP_LOC101241166.1.1 m.31892 sp CO5A1_RAT 34.715 193 108 6 206 383 40 229 7.21E-23 104 CO5A1_RAT reviewed Collagen alpha-1(V) chain Col5a1 Rattus norvegicus (Rat) 1840 0 GO:0005201; GO:0005588; GO:0008201 0 0 0 PF01410;PF01391;PF02210; Q9N1Q0 CHOYP_RSMB.1.2 m.12400 sp RSMB_MACEU 77.551 147 31 1 1 145 1 147 7.21E-73 222 RSMB_MACEU reviewed Small nuclear ribonucleoprotein-associated protein B' (snRNP-B') (snRPB') (Sm protein B') (Sm-B') (SmB') SNRPB Macropus eugenii (Tammar wallaby) 240 spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0003723; GO:0005681; GO:0005683; GO:0005685; GO:0005687; GO:0005829; GO:0034709; GO:0034719 0 0 0 PF01423; Q9N1Q0 CHOYP_RSMB.2.2 m.37628 sp RSMB_MACEU 77.551 147 31 1 1 145 1 147 7.21E-73 222 RSMB_MACEU reviewed Small nuclear ribonucleoprotein-associated protein B' (snRNP-B') (snRPB') (Sm protein B') (Sm-B') (SmB') SNRPB Macropus eugenii (Tammar wallaby) 240 spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0003723; GO:0005681; GO:0005683; GO:0005685; GO:0005687; GO:0005829; GO:0034709; GO:0034719 0 0 0 PF01423; Q9WVE8 CHOYP_PACN2.2.2 m.25018 sp PACN2_MOUSE 37.591 548 267 9 8 553 11 485 7.21E-123 373 PACN2_MOUSE reviewed Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) Pacsin2 Mus musculus (Mouse) 486 actin cytoskeleton organization [GO:0030036]; caveola assembly [GO:0070836]; caveolin-mediated endocytosis [GO:0072584]; cell projection morphogenesis [GO:0048858]; membrane tubulation [GO:0097320]; negative regulation of endocytosis [GO:0045806]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165] GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005856; GO:0005901; GO:0005911; GO:0005925; GO:0007165; GO:0008092; GO:0008289; GO:0019898; GO:0030036; GO:0030659; GO:0032587; GO:0036010; GO:0042802; GO:0043231; GO:0045806; GO:0048858; GO:0055038; GO:0070062; GO:0070300; GO:0070836; GO:0072584; GO:0097320 0 0 0 PF00611;PF00018; O70277 CHOYP_contig_041269 m.47060 sp TRIM3_RAT 25 252 160 12 8 241 455 695 7.22E-08 56.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P41116 CHOYP_RL8.8.10 m.59040 sp RL8_XENLA 83.902 205 33 0 25 229 46 250 7.22E-127 362 RL8_XENLA reviewed 60S ribosomal protein L8 rpl8 Xenopus laevis (African clawed frog) 257 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934; GO:0019843 0 0 0 PF00181;PF03947; Q28024 CHOYP_LOC100081920.1.4 m.1772 sp GBG12_BOVIN 43.077 65 35 1 88 150 8 72 7.22E-12 60.5 GBG12_BOVIN reviewed Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Gamma-S1) GNG12 GNGT12 Bos taurus (Bovine) 72 G-protein coupled receptor signaling pathway [GO:0007186] GO:0004871; GO:0005834; GO:0007186; GO:0070062 0 0 cd00068; PF00631; Q3HNG7 CHOYP_ISCW_ISCW003704.1.1 m.6943 sp H1FOO_BOVIN 40.909 66 39 0 16 81 48 113 7.22E-12 66.2 H1FOO_BOVIN reviewed Histone H1oo (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) H1FOO H1OO Bos taurus (Bovine) 343 meiotic cell cycle [GO:0051321]; negative regulation of stem cell differentiation [GO:2000737]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; regulation of DNA methylation [GO:0044030] GO:0000786; GO:0005634; GO:0005737; GO:0006334; GO:0016584; GO:0031492; GO:0044030; GO:0051321; GO:2000737 0 0 0 PF00538; Q62158 CHOYP_TIF1A.4.8 m.23900 sp TRI27_MOUSE 35.714 84 49 2 44 123 70 152 7.22E-07 50.8 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q71RS6 CHOYP_SLC24A5.1.1 m.26344 sp NCKX5_HUMAN 42.056 321 163 7 2 314 190 495 7.22E-77 246 NCKX5_HUMAN reviewed Sodium/potassium/calcium exchanger 5 (Na(+)/K(+)/Ca(2+)-exchange protein 5) (Solute carrier family 24 member 5) SLC24A5 JSX NCKX5 Homo sapiens (Human) 500 cellular calcium ion homeostasis [GO:0006874]; ion transmembrane transport [GO:0034220]; ion transport [GO:0006811]; negative regulation of melanin biosynthetic process [GO:0048022]; response to stimulus [GO:0050896] GO:0005262; GO:0005509; GO:0005802; GO:0006811; GO:0006874; GO:0008273; GO:0015293; GO:0016021; GO:0030955; GO:0031402; GO:0032588; GO:0034220; GO:0042470; GO:0048022; GO:0050896 0 0 0 PF01699; Q8R0K4 CHOYP_LOC661695.1.1 m.11545 sp CC137_MOUSE 31.535 241 137 5 57 292 45 262 7.22E-18 85.1 CC137_MOUSE reviewed Coiled-coil domain-containing protein 137 Ccdc137 Mus musculus (Mouse) 290 0 GO:0005694; GO:0005730; GO:0044822 0 0 0 0 Q8R238 CHOYP_LOC100367535.1.2 m.4730 sp SDSL_MOUSE 50 312 155 1 14 324 12 323 7.22E-96 290 SDSL_MOUSE reviewed Serine dehydratase-like (EC 4.3.1.17) (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (SDH) Sdsl Sds Mus musculus (Mouse) 329 0 GO:0003941; GO:0004794; GO:0005739; GO:0030170; GO:0070062 0 0 0 PF00291; Q9BRZ2 CHOYP_LOC100378676.1.8 m.13911 sp TRI56_HUMAN 26.804 194 120 5 35 218 16 197 7.22E-12 72.4 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9U3W6 CHOYP_NEMVEDRAFT_V1G196611.11.13 m.55339 sp MAB21_DROME 24.706 170 110 5 120 280 183 343 7.22E-07 55.5 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; Q9Y4F5 CHOYP_SRAP.10.18 m.43353 sp C170B_HUMAN 50 96 48 0 11 106 6 101 7.22E-26 120 C170B_HUMAN reviewed Centrosomal protein of 170 kDa protein B (Centrosomal protein 170B) (Cep170B) CEP170B FAM68C KIAA0284 Homo sapiens (Human) 1589 0 GO:0005737; GO:0005874 0 0 0 PF15308;PF00498; A2AV25 CHOYP_BRAFLDRAFT_125263.3.9 m.42600 sp FBCD1_MOUSE 33.828 337 195 9 60 371 121 454 7.23E-51 179 FBCD1_MOUSE reviewed Fibrinogen C domain-containing protein 1 Fibcd1 Mus musculus (Mouse) 459 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; B0BML1 CHOYP_LOC100641815.1.1 m.29616 sp GNTK_XENTR 46.243 173 93 0 1 173 1 173 7.23E-48 157 GNTK_XENTR reviewed Probable gluconokinase (EC 2.7.1.12) (Gluconate kinase) idnk Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 190 cellular carbohydrate metabolic process [GO:0044262]; D-gluconate catabolic process [GO:0046177] GO:0005524; GO:0044262; GO:0046177; GO:0046316 PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation. 0 cd02021; PF01202; D2GXS7 CHOYP_BRAFLDRAFT_69798.16.22 m.52707 sp TRIM2_AILME 23.179 151 106 3 9 158 602 743 7.23E-06 49.3 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; J3SBP3 CHOYP_ENPP3.1.1 m.13519 sp PDE2_CROAD 40.541 740 374 23 129 828 77 790 7.23E-161 521 PDE2_CROAD reviewed Venom phosphodiesterase 2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 3) (PDE-3) [Includes: Alkaline phosphodiesterase I (PDE) (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9)] 0 Crotalus adamanteus (Eastern diamondback rattlesnake) 810 immune response [GO:0006955] GO:0003676; GO:0004528; GO:0005044; GO:0005576; GO:0006955; GO:0030247; GO:0035529; GO:0046872 0 0 0 PF01223;PF01663;PF01033; O00165 CHOYP_LOC100119650.1.1 m.60147 sp HAX1_HUMAN 31.472 197 96 9 69 246 72 248 7.23E-07 53.5 HAX1_HUMAN reviewed HCLS1-associated protein X-1 (HS1-associating protein X-1) (HAX-1) (HS1-binding protein 1) (HSP1BP-1) HAX1 HS1BP1 Homo sapiens (Human) 279 cellular response to cytokine stimulus [GO:0071345]; negative regulation of apoptotic process [GO:0043066]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of granulocyte differentiation [GO:0030854]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of actin filament polymerization [GO:0030833]; regulation of apoptotic process [GO:0042981]; regulation of mitophagy [GO:1903146]; regulation of protein targeting to mitochondrion [GO:1903214] GO:0005635; GO:0005667; GO:0005739; GO:0005741; GO:0005758; GO:0005783; GO:0014068; GO:0015629; GO:0016023; GO:0016529; GO:0019966; GO:0030027; GO:0030833; GO:0030854; GO:0031965; GO:0033138; GO:0042981; GO:0043066; GO:0045944; GO:0047485; GO:0050731; GO:0051897; GO:0071345; GO:1903146; GO:1903214; GO:2000251 0 0 0 0 P34416 CHOYP_LOC663855.4.5 m.42170 sp LASP1_CAEEL 39.041 146 76 2 1 146 73 205 7.23E-25 100 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P42674 CHOYP_LOC100548534.1.1 m.26484 sp BP10_PARLI 29.219 397 253 13 173 558 70 449 7.23E-39 156 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P86788 CHOYP_GIGA5.1.4 m.4359 sp GIGA5_CRAGI 90.217 92 8 1 131 222 23 113 7.23E-39 133 GIGA5_CRAGI reviewed Gigasin-5 (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 113 0 0 0 0 0 0 Q10576 CHOYP_P4HA1.4.5 m.59821 sp P4HA1_CAEEL 23.65 537 337 18 10 491 3 521 7.23E-19 93.2 P4HA1_CAEEL reviewed "Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) (Protein dumpy-18)" dpy-18 phy-1 Y47D3B.10 Caenorhabditis elegans 559 collagen and cuticulin-based cuticle development [GO:0040002]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic body morphogenesis [GO:0010172]; macromolecule modification [GO:0043412]; oxidation-reduction process [GO:0055114]; peptidyl-proline hydroxylation [GO:0019511]; positive regulation of multicellular organism growth [GO:0040018] GO:0004656; GO:0005506; GO:0005623; GO:0005783; GO:0005788; GO:0009792; GO:0010172; GO:0016702; GO:0019511; GO:0031418; GO:0031545; GO:0040002; GO:0040018; GO:0043412; GO:0055114 0 0 0 PF13640;PF08336; Q4UMH6 CHOYP_LITD.1.1 m.47683 sp Y381_RICFE 24.641 418 233 12 303 661 637 1031 7.23E-20 98.6 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q63421 CHOYP_DMOJ_GI17690.1.1 m.48370 sp PDE1C_RAT 35.897 156 78 4 47 194 5 146 7.23E-14 73.2 PDE1C_RAT reviewed "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Rattus norvegicus (Rat) 768 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of insulin secretion [GO:0046676]; response to calcium ion [GO:0051592]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] GO:0004115; GO:0004117; GO:0006198; GO:0007165; GO:0007608; GO:0030552; GO:0043025; GO:0046069; GO:0046676; GO:0046872; GO:0048101; GO:0051592 0 0 0 PF00233;PF08499; Q6P8Y1 CHOYP_LOC100179300.1.2 m.22734 sp CAPSL_MOUSE 50.481 208 102 1 43 250 2 208 7.23E-78 236 CAPSL_MOUSE reviewed Calcyphosin-like protein Capsl Mus musculus (Mouse) 208 0 GO:0005509; GO:0005737 0 0 0 PF13499; Q8BP00 CHOYP_LOC577357.1.1 m.19189 sp IQCB1_MOUSE 33.854 576 370 7 11 582 7 575 7.23E-100 318 IQCB1_MOUSE reviewed IQ calmodulin-binding motif-containing protein 1 Iqcb1 Kiaa0036 Mus musculus (Mouse) 598 cilium assembly [GO:0042384]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494] GO:0001750; GO:0005516; GO:0005654; GO:0005737; GO:0005813; GO:0015630; GO:0019899; GO:0032391; GO:0042384; GO:0045171; GO:0045494; GO:0048496; GO:0070062 0 0 0 PF00612; Q8K0U4 CHOYP_BRAFLDRAFT_240135.1.1 m.40596 sp HS12A_MOUSE 24.638 138 101 1 3 137 536 673 7.23E-07 50.4 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q9BG93 CHOYP_BRAFLDRAFT_87834.1.1 m.37325 sp NR0B1_MACMU 29.412 221 132 2 261 457 246 466 7.23E-21 98.2 NR0B1_MACMU reviewed Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1) NR0B1 DAX1 Macaca mulatta (Rhesus macaque) 470 "adrenal gland development [GO:0030325]; gonad development [GO:0008406]; male gonad development [GO:0008584]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein localization [GO:0008104]; steroid biosynthetic process [GO:0006694]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003707; GO:0003714; GO:0003723; GO:0004879; GO:0005634; GO:0005737; GO:0006351; GO:0006694; GO:0008104; GO:0008134; GO:0008406; GO:0008584; GO:0016020; GO:0019904; GO:0030325; GO:0032448; GO:0033144; GO:0035258; GO:0042788; GO:0042803; GO:0043433; GO:0043565; GO:0045892 0 0 0 PF00104;PF14046; Q9XHH2 CHOYP_BRAFLDRAFT_69981.1.1 m.62205 sp DNAL1_CHLRE 33.784 148 83 5 16 151 47 191 7.23E-09 60.5 DNAL1_CHLRE reviewed "Dynein light chain 1, axonemal (Flagellar outer arm dynein light chain 1)" LC1 Chlamydomonas reinhardtii (Chlamydomonas smithii) 198 0 GO:0003774; GO:0005737; GO:0005874; GO:0031514; GO:0036157 0 0 0 PF12799; Q9Y2M2 CHOYP_BRAFLDRAFT_276314.3.3 m.53475 sp SSUH2_HUMAN 38.462 312 182 3 197 504 48 353 7.23E-75 243 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 A2AX52 CHOYP_LOC100186070.1.1 m.3415 sp CO6A4_MOUSE 34.081 223 126 6 172 381 829 1043 7.24E-25 115 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; P17126 CHOYP_ACT.26.27 m.66245 sp ACT_HYDVU 94.681 94 5 0 9 102 218 311 7.24E-59 189 ACT_HYDVU reviewed "Actin, non-muscle 6.2" 0 Hydra vulgaris (Hydra) (Hydra attenuata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P27657 CHOYP_LOC100638885.4.4 m.61425 sp LIPP_RAT 38.034 234 131 8 85 304 80 313 7.24E-38 144 LIPP_RAT reviewed Pancreatic triacylglycerol lipase (PL) (Pancreatic lipase) (EC 3.1.1.3) Pnlip Rattus norvegicus (Rat) 465 lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; post-embryonic development [GO:0009791]; response to lipid [GO:0033993]; response to peptide hormone [GO:0043434] GO:0004806; GO:0005615; GO:0006629; GO:0009791; GO:0016042; GO:0016298; GO:0033993; GO:0043434; GO:0046872 0 0 0 PF00151;PF01477; P35559 CHOYP_LOC101066029.1.1 m.64965 sp IDE_RAT 60.455 220 86 1 3 222 43 261 7.24E-87 280 IDE_RAT reviewed Insulin-degrading enzyme (EC 3.4.24.56) (Insulin protease) (Insulinase) (Insulysin) Ide Rattus norvegicus (Rat) 1019 beta-amyloid metabolic process [GO:0050435]; bradykinin catabolic process [GO:0010815]; cellular protein catabolic process [GO:0044257]; determination of adult lifespan [GO:0008340]; hormone catabolic process [GO:0042447]; insulin catabolic process [GO:1901143]; negative regulation of proteolysis [GO:0045861]; peptide catabolic process [GO:0043171]; positive regulation of protein oligomerization [GO:0032461]; protein heterooligomerization [GO:0051291]; protein homotetramerization [GO:0051289]; protein processing [GO:0016485]; proteolysis involved in cellular protein catabolic process [GO:0051603]; ubiquitin homeostasis [GO:0010992] GO:0001540; GO:0001948; GO:0004222; GO:0005524; GO:0005615; GO:0005634; GO:0005654; GO:0005739; GO:0005782; GO:0005829; GO:0005886; GO:0008233; GO:0008270; GO:0008340; GO:0009986; GO:0010815; GO:0010992; GO:0016485; GO:0016887; GO:0017046; GO:0031597; GO:0031626; GO:0032461; GO:0042447; GO:0042803; GO:0043171; GO:0043559; GO:0044257; GO:0045861; GO:0050435; GO:0051289; GO:0051291; GO:0051603; GO:1901143 0 0 0 PF00675;PF05193;PF16187; P70207 CHOYP_PLXA4.2.2 m.41028 sp PLXA2_MOUSE 23.248 314 211 12 4 299 431 732 7.24E-19 91.7 PLXA2_MOUSE reviewed Plexin-A2 (Plex 2) (Plexin-2) Plxna2 Kiaa0463 Mus musculus (Mouse) 1894 branchiomotor neuron axon guidance [GO:0021785]; cell surface receptor signaling pathway [GO:0007166]; centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; regulation of axon extension involved in axon guidance [GO:0048841]; regulation of cell migration [GO:0030334]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756] GO:0001756; GO:0002116; GO:0005886; GO:0005887; GO:0007166; GO:0017154; GO:0021785; GO:0021915; GO:0021935; GO:0030334; GO:0048841; GO:0051642; GO:0060037; GO:0060174; GO:0071526; GO:1902287 0 0 0 PF08337;PF01437;PF01403;PF01833; P86856 CHOYP_MANL.9.9 m.62806 sp MANL_MYTCA 35.372 376 133 10 56 390 2 308 7.24E-55 188 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q09654 CHOYP_LOC100368020.12.29 m.23981 sp TRI23_CAEEL 27.673 159 93 6 19 155 115 273 7.24E-08 53.9 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q26065 CHOYP_ACT3A.1.1 m.25940 sp ACT_PLAMG 95.259 232 10 1 16 246 136 367 7.24E-156 442 ACT_PLAMG reviewed "Actin, adductor muscle" 0 Placopecten magellanicus (Sea scallop) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q6NS45 CHOYP_BRAFLDRAFT_121183.1.8 m.13628 sp CCD66_MOUSE 36.735 147 92 1 766 912 438 583 7.24E-12 73.9 CCD66_MOUSE reviewed Coiled-coil domain-containing protein 66 Ccdc66 Mus musculus (Mouse) 935 detection of light stimulus involved in visual perception [GO:0050908]; post-embryonic retina morphogenesis in camera-type eye [GO:0060060]; retinal rod cell development [GO:0046548] GO:0046548; GO:0050908; GO:0060060 0 0 0 0 Q9BWV7 CHOYP_BRAFLDRAFT_279373.1.1 m.48904 sp TTLL2_HUMAN 54.762 336 149 2 6 341 85 417 7.24E-137 422 TTLL2_HUMAN reviewed Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2) TTLL2 C6orf104 Homo sapiens (Human) 592 cellular protein modification process [GO:0006464] GO:0005524; GO:0006464; GO:0016874 0 0 0 PF03133; Q9CZJ2 CHOYP_HSPA12A.26.27 m.65380 sp HS12B_MOUSE 30 630 367 18 1095 1657 59 681 7.24E-74 265 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9M0X9 CHOYP_contig_018202 m.21342 sp 4CLL7_ARATH 25.338 517 335 20 15 514 25 507 7.24E-22 102 4CLL7_ARATH reviewed 4-coumarate--CoA ligase-like 7 (EC 6.2.1.-) (4-coumarate--CoA ligase isoform 6) (At4CL6) 4CLL7 At4g05160 C17L7.80 Arabidopsis thaliana (Mouse-ear cress) 544 fatty acid biosynthetic process [GO:0006633]; jasmonic acid biosynthetic process [GO:0009695]; oxylipin biosynthetic process [GO:0031408] GO:0004321; GO:0005524; GO:0005777; GO:0006633; GO:0009695; GO:0016874; GO:0031408 0 0 0 PF00501;PF13193; D3ZQG6 CHOYP_BRAFLDRAFT_69764.14.19 m.39449 sp TRIM2_RAT 22.17 212 133 7 38 233 492 687 7.25E-06 50.1 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O60287 CHOYP_RL23.5.11 m.19020 sp NPA1P_HUMAN 30 100 64 3 1 99 451 545 7.25E-07 49.3 NPA1P_HUMAN reviewed Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog) URB1 C21orf108 KIAA0539 NOP254 NPA1 Homo sapiens (Human) 2271 0 GO:0005730; GO:0044822 0 0 0 PF16201;PF11707; P06868 CHOYP_LOC100028030.1.1 m.63979 sp PLMN_BOVIN 49.727 183 74 6 266 433 189 368 7.25E-45 172 PLMN_BOVIN reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Bos taurus (Bovine) 812 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; response to heat [GO:0009408]; tissue remodeling [GO:0048771] GO:0004252; GO:0005102; GO:0005576; GO:0007596; GO:0009408; GO:0019904; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P30531 CHOYP_LOC100313675.1.1 m.34809 sp SC6A1_HUMAN 21.366 454 305 12 23 457 33 453 7.25E-16 84.7 SC6A1_HUMAN reviewed Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) SLC6A1 GABATR GABT1 GAT1 Homo sapiens (Human) 599 "chemical synaptic transmission [GO:0007268]; gamma-aminobutyric acid import [GO:0051939]; gamma-aminobutyric acid transport [GO:0015812]; learning [GO:0007612]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of synaptic transmission, GABAergic [GO:0032229]; neurotransmitter transport [GO:0006836]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; protein homooligomerization [GO:0051260]; response to calcium ion [GO:0051592]; response to cocaine [GO:0042220]; response to estradiol [GO:0032355]; response to lead ion [GO:0010288]; response to purine-containing compound [GO:0014074]; response to sucrose [GO:0009744]; response to toxic substance [GO:0009636]; transport [GO:0006810]" GO:0005328; GO:0005332; GO:0005886; GO:0005887; GO:0006810; GO:0006836; GO:0007268; GO:0007612; GO:0009636; GO:0009744; GO:0009986; GO:0010288; GO:0014054; GO:0014074; GO:0015812; GO:0016020; GO:0016021; GO:0030424; GO:0032229; GO:0032355; GO:0042220; GO:0043005; GO:0046872; GO:0051260; GO:0051592; GO:0051939; GO:0098779 0 0 0 PF00209; P41937 CHOYP_TBB.6.7 m.64498 sp TBB4_CAEEL 92.135 178 14 0 1 178 267 444 7.25E-120 348 TBB4_CAEEL reviewed Tubulin beta-4 chain (Beta-4-tubulin) tbb-4 B0272.1 Caenorhabditis elegans 444 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005879; GO:0007017 0 0 0 PF00091;PF03953; P57103 CHOYP_BRAFLDRAFT_78683.2.4 m.31427 sp NAC3_HUMAN 32.457 989 474 29 20 930 49 921 7.25E-136 433 NAC3_HUMAN reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) SLC8A3 NCX3 Homo sapiens (Human) 927 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; ion transport [GO:0006811]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of cardiac conduction [GO:1903779]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005886; GO:0005887; GO:0006811; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0016528; GO:0021537; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1903779; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; Q0P5B7 CHOYP_AAAD.4.4 m.45842 sp AAAD_BOVIN 38.047 297 159 13 85 370 13 295 7.25E-45 162 AAAD_BOVIN reviewed Arylacetamide deacetylase (EC 3.1.1.3) AADAC Bos taurus (Bovine) 399 metabolic process [GO:0008152]; positive regulation of triglyceride catabolic process [GO:0010898] GO:0004806; GO:0005789; GO:0008152; GO:0010898; GO:0016021; GO:0017171; GO:0031090 0 0 0 PF07859; Q0VAW7 CHOYP_ZN184.4.4 m.59187 sp ZN112_MOUSE 37.857 140 81 4 310 446 601 737 7.25E-21 99.4 ZN112_MOUSE reviewed Zinc finger protein 112 (Zfp-112) Znf112 Zfp112 Mus musculus (Mouse) 879 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q13263 CHOYP_TIF1B.9.10 m.53300 sp TIF1B_HUMAN 30.323 155 99 4 28 178 135 284 7.25E-09 57.8 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q1RKN3 CHOYP_BRAFLDRAFT_82911.1.1 m.64225 sp TLH2_SCHPO 24.5 200 134 4 19 215 1417 1602 7.25E-12 67.8 TLH2_SCHPO reviewed ATP-dependent DNA helicase tlh2 (EC 3.6.4.12) (Sub-telomeric helicase RecQ homolog 2) tlh2 SPBCPT2R1.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1919 base-excision repair [GO:0006284]; cell aging [GO:0007569]; cellular response to gamma radiation [GO:0071480]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; replication fork processing [GO:0031297]; telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000731; GO:0000784; GO:0003677; GO:0005524; GO:0005654; GO:0005737; GO:0006284; GO:0006302; GO:0007569; GO:0008270; GO:0009378; GO:0031297; GO:0043140; GO:0071480 0 0 0 PF00270;PF00271; Q3UIR3 CHOYP_LOC101061217.1.1 m.43029 sp DTX3L_MOUSE 54.688 192 85 2 118 308 557 747 7.25E-61 209 DTX3L_MOUSE reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (Protein deltex-3-like) Dtx3l Bbap Mus musculus (Mouse) 748 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q52QT8 CHOYP_CCNG2.1.1 m.62899 sp CCNG1_PIG 32.701 211 135 4 68 273 52 260 7.25E-23 100 CCNG1_PIG reviewed Cyclin-G1 CCNG1 Sus scrofa (Pig) 295 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; regulation of cell cycle [GO:0051726] GO:0005634; GO:0007067; GO:0051301; GO:0051726 0 0 0 PF00134; Q6NT55 CHOYP_LOC100368112.1.1 m.26309 sp CP4FN_HUMAN 44.328 476 249 7 34 501 59 526 7.25E-130 390 CP4FN_HUMAN reviewed Cytochrome P450 4F22 (EC 1.14.14.-) CYP4F22 Homo sapiens (Human) 531 icosanoid metabolic process [GO:0006690] GO:0004497; GO:0005506; GO:0005789; GO:0006690; GO:0016705; GO:0020037; GO:0031090 0 0 0 PF00067; Q6PDC8 CHOYP_BRAFLDRAFT_209565.1.1 m.541 sp MFD4A_MOUSE 31.151 504 297 8 9 480 4 489 7.25E-59 206 MFD4A_MOUSE reviewed Major facilitator superfamily domain-containing protein 4A (Major facilitator superfamily domain-containing protein 4) Mfsd4a Mfsd4 Mus musculus (Mouse) 510 transmembrane transport [GO:0055085] GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6ZQ82 CHOYP_AAEL_AAEL014308.1.1 m.62736 sp RHG26_MOUSE 58.065 62 26 0 69 130 753 814 7.25E-18 81.6 RHG26_MOUSE reviewed Rho GTPase-activating protein 26 (Rho-type GTPase-activating protein 26) Arhgap26 Kiaa0621 Mus musculus (Mouse) 814 actin cytoskeleton organization [GO:0030036]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005543; GO:0005737; GO:0005856; GO:0005925; GO:0007165; GO:0030036; GO:0051056 0 0 0 PF00169;PF00620;PF14604; Q8N6Q8 CHOYP_BRAFLDRAFT_74144.1.1 m.17715 sp MET25_HUMAN 25.957 470 271 16 3 415 151 600 7.25E-26 113 MET25_HUMAN reviewed Methyltransferase-like protein 25 (EC 2.1.1.-) METTL25 C12orf26 Homo sapiens (Human) 603 0 GO:0008168 0 0 0 PF13679; B0BNA5 CHOYP_LOC100369954.1.1 m.22658 sp COTL1_RAT 46.617 133 71 0 4 136 5 137 7.26E-37 125 COTL1_RAT reviewed Coactosin-like protein Cotl1 Clp Rattus norvegicus (Rat) 142 defense response to fungus [GO:0050832] GO:0005634; GO:0005737; GO:0005856; GO:0050832; GO:0070062 0 0 0 PF00241; O15072 CHOYP_ATS3.1.1 m.32198 sp ATS3_HUMAN 24.946 465 279 18 133 589 200 602 7.26E-22 105 ATS3_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAM-TS 3) (ADAM-TS3) (ADAMTS-3) (EC 3.4.24.-) (Procollagen II N-proteinase) (PC II-NP) (Procollagen II amino propeptide-processing enzyme) ADAMTS3 KIAA0366 Homo sapiens (Human) 1205 collagen biosynthetic process [GO:0032964]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; extracellular fibril organization [GO:0043206]; positive regulation of vascular endothelial growth factor signaling pathway [GO:1900748]; protein processing [GO:0016485]; vascular endothelial growth factor production [GO:0010573] GO:0004175; GO:0004222; GO:0005576; GO:0005578; GO:0005615; GO:0008201; GO:0008270; GO:0010573; GO:0016485; GO:0030199; GO:0030574; GO:0032964; GO:0043206; GO:0070062; GO:1900748 0 0 0 PF05986;PF01562;PF01421;PF00090; O95210 CHOYP_STBD1.1.1 m.50712 sp STBD1_HUMAN 33.673 98 59 2 2 99 264 355 7.26E-07 51.6 STBD1_HUMAN reviewed Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) STBD1 GENX-3414 Homo sapiens (Human) 358 glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; muscle contraction [GO:0006936] GO:0005789; GO:0005887; GO:0005980; GO:0006936; GO:0016020; GO:0034045; GO:0048471; GO:0061723; GO:2001069; GO:2001070 0 0 0 PF00686; P10079 CHOYP_BRAFLDRAFT_211833.1.1 m.6041 sp FBP1_STRPU 51.042 192 94 0 1 192 185 376 7.26E-59 201 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P46720 CHOYP_SLCO2B1.1.1 m.8156 sp SO1A1_RAT 29.889 629 393 18 16 603 31 652 7.26E-83 276 SO1A1_RAT reviewed Solute carrier organic anion transporter family member 1A1 (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter 1) (Solute carrier family 21 member 1) Slco1a1 Oatp1 Oatp1a1 Slc21a1 Rattus norvegicus (Rat) 670 bile acid metabolic process [GO:0008206]; organic anion transport [GO:0015711]; response to stilbenoid [GO:0035634]; response to testosterone [GO:0033574]; sodium-independent organic anion transport [GO:0043252] GO:0005887; GO:0008206; GO:0008514; GO:0015125; GO:0015347; GO:0015711; GO:0016323; GO:0033574; GO:0035634; GO:0043252 0 0 cd06174; PF07648;PF03137; P80895 CHOYP_BRAFLDRAFT_284774.2.3 m.15260 sp PIMT_PIG 63.755 229 81 1 1 229 1 227 7.26E-105 305 PIMT_PIG reviewed Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) PCMT1 Sus scrofa (Pig) 227 0 GO:0004719; GO:0005737 0 0 0 0 P80912 CHOYP_HINT1.1.1 m.53526 sp HINT1_RABIT 69.048 126 39 0 22 147 1 126 7.26E-63 191 HINT1_RABIT reviewed Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (P13.7) HINT1 HINT Oryctolagus cuniculus (Rabbit) 126 "intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; purine ribonucleotide catabolic process [GO:0009154]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000166; GO:0005737; GO:0006351; GO:0006355; GO:0009154; GO:0016787; GO:0072332 0 0 0 PF01230; Q02040 CHOYP_AK17A.1.1 m.8473 sp AK17A_HUMAN 55.111 450 188 5 1 447 1 439 7.26E-137 417 AK17A_HUMAN reviewed "A-kinase anchor protein 17A (AKAP-17A) (721P) (B-lymphocyte antigen) (Protein XE7) (Protein kinase A-anchoring protein 17A) (PRKA17A) (Splicing factor, arginine/serine-rich 17A)" AKAP17A CXYorf3 DXYS155E SFRS17A XE7 Homo sapiens (Human) 695 "B cell activation [GO:0042113]; mRNA processing [GO:0006397]; regulation of RNA splicing [GO:0043484]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]" GO:0000166; GO:0005634; GO:0005654; GO:0005681; GO:0005737; GO:0006355; GO:0006397; GO:0007165; GO:0008380; GO:0016607; GO:0042113; GO:0043484; GO:0044822; GO:0051018 0 0 0 0 Q08200 CHOYP_RPL10.2.2 m.40394 sp RL10_CHICK 86.047 86 12 0 32 117 3 88 7.26E-52 166 RL10_CHICK reviewed 60S ribosomal protein L10 (Jun-binding protein JIF-1) (Fragment) RPL10 JIF1 Gallus gallus (Chicken) 210 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005634; GO:0006412; GO:0022625 0 0 cd01433; PF00252; Q8IY22 CHOYP_LOC101168708.1.1 m.55576 sp CMIP_HUMAN 60.185 324 128 1 382 704 450 773 7.26E-127 397 CMIP_HUMAN reviewed C-Maf-inducing protein (c-Mip) (Truncated c-Maf-inducing protein) (Tc-Mip) CMIP KIAA1694 TCMIP Homo sapiens (Human) 773 0 GO:0005634; GO:0005737 0 0 0 0 Q9U3P2 CHOYP_MAG.1.1 m.33647 sp SYG2_CAEEL 26.531 196 110 9 120 286 21 211 7.26E-06 52 SYG2_CAEEL reviewed Synaptogenesis protein syg-2 (Synaptogenesis abnormal protein 2) syg-2 C26G2.1 Caenorhabditis elegans 1270 cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; collateral sprouting [GO:0048668]; protein localization to synapse [GO:0035418]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; synaptic target recognition [GO:0008039] GO:0005887; GO:0007155; GO:0007267; GO:0007416; GO:0008039; GO:0030054; GO:0035418; GO:0042803; GO:0045202; GO:0048668; GO:0050808; GO:0050839 0 0 0 PF08205;PF00041;PF07679; A4IF63 CHOYP_BRAFLDRAFT_67264.6.6 m.64609 sp TRIM2_BOVIN 23.448 145 106 2 412 554 602 743 7.27E-10 65.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; F1R8Z9 CHOYP_FOXJ1.1.1 m.11395 sp FXJ1B_DANRE 41.141 333 145 10 1 294 1 321 7.27E-66 219 FXJ1B_DANRE reviewed Forkhead box protein J1-B foxj1b foxj1.2 Danio rerio (Zebrafish) (Brachydanio rerio) 442 "auditory receptor cell stereocilium organization [GO:0060088]; cilium assembly [GO:0042384]; determination of left/right symmetry [GO:0007368]; heart jogging [GO:0003146]; heart looping [GO:0001947]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0001947; GO:0003146; GO:0005634; GO:0006351; GO:0007368; GO:0042384; GO:0043565; GO:0060088 0 0 0 PF00250; O75094 CHOYP_LOC101078252.1.1 m.39219 sp SLIT3_HUMAN 17.647 272 190 6 53 320 32 273 7.27E-07 55.1 SLIT3_HUMAN reviewed Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5) SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336 Homo sapiens (Human) 1523 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; organ morphogenesis [GO:0009887]; regulation of axonogenesis [GO:0050770]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385] GO:0005509; GO:0005578; GO:0005615; GO:0005739; GO:0007411; GO:0008201; GO:0008285; GO:0009887; GO:0010629; GO:0030308; GO:0032870; GO:0035385; GO:0048495; GO:0048846; GO:0050770; GO:0050919; GO:0051414; GO:0061364; GO:0070100 0 0 0 PF00008;PF02210;PF13855;PF01463;PF01462; O75382 CHOYP_NHL1.4.6 m.14221 sp TRIM3_HUMAN 28.283 297 186 8 764 1043 458 744 7.27E-26 118 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06916 CHOYP_PF08_0127.2.2 m.64033 sp FIRA_PLAFF 56.364 55 24 0 931 985 48 102 7.27E-06 52.8 FIRA_PLAFF reviewed 300 kDa antigen AG231 (Fragment) FIRA Plasmodium falciparum (isolate FC27 / Papua New Guinea) 310 0 0 0 0 0 PF07016; P24461 CHOYP_BRAFLDRAFT_61459.2.3 m.20701 sp CP2G1_RABIT 35.129 464 268 11 35 477 9 460 7.27E-89 284 CP2G1_RABIT reviewed Cytochrome P450 2G1 (EC 1.14.14.1) (CYPIIG1) (Cytochrome P450 olfactive) (Cytochrome P450-NMB) CYP2G1 Oryctolagus cuniculus (Rabbit) 494 response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608] GO:0005506; GO:0005789; GO:0007608; GO:0020037; GO:0031090; GO:0050896; GO:0070330 0 0 0 PF00067; P30622 CHOYP_CLIP1.2.2 m.25061 sp CLIP1_HUMAN 47.872 94 43 3 14 103 1302 1393 7.27E-19 84.7 CLIP1_HUMAN reviewed CAP-Gly domain-containing linker protein 1 (Cytoplasmic linker protein 1) (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed-Sternberg intermediate filament-associated protein) (Restin) CLIP1 CYLN1 RSN Homo sapiens (Human) 1438 microtubule bundle formation [GO:0001578]; mitotic nuclear division [GO:0007067]; positive regulation of microtubule polymerization [GO:0031116]; protein transport into plasma membrane raft [GO:0044861]; sister chromatid cohesion [GO:0007062] GO:0000776; GO:0001578; GO:0001726; GO:0005737; GO:0005768; GO:0005813; GO:0005829; GO:0005874; GO:0005881; GO:0005882; GO:0007062; GO:0007067; GO:0008017; GO:0008270; GO:0015630; GO:0015631; GO:0030659; GO:0031116; GO:0035371; GO:0042803; GO:0044861; GO:0046872; GO:0051010; GO:1990752 0 0 0 PF01302;PF16641; P47967 CHOYP_LOC100378653.1.3 m.42107 sp LEG5_RAT 45.255 137 66 3 482 617 15 143 7.27E-27 109 LEG5_RAT reviewed Galectin-5 (Gal-5) (RL-18) Lgals5 Rattus norvegicus (Rat) 145 0 GO:0030246 0 0 0 PF00337; Q2VR06 CHOYP_LOC100123748.1.1 m.223 sp F92AA_XENLA 40.127 157 92 1 39 195 6 160 7.27E-33 122 F92AA_XENLA reviewed Protein FAM92A1-A fam92a1-a Xenopus laevis (African clawed frog) 284 0 0 0 0 0 PF06730; Q3B8G0 CHOYP_BRAFLDRAFT_120923.1.3 m.26836 sp CA123_XENLA 58.75 160 64 1 20 179 1 158 7.27E-67 204 CA123_XENLA reviewed UPF0587 protein C1orf123 homolog 0 Xenopus laevis (African clawed frog) 160 0 0 0 0 0 PF05907; Q5G268 CHOYP_DMBT1.20.34 m.42555 sp NETR_NOMLE 46.479 213 111 2 261 473 279 488 7.27E-54 202 NETR_NOMLE reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q61542 CHOYP_HMCN1.41.44 m.63262 sp STAR3_MOUSE 33.242 364 217 8 1 356 101 446 7.27E-57 194 STAR3_MOUSE reviewed StAR-related lipid transfer protein 3 (Protein ES 64) (Protein MLN 64) (START domain-containing protein 3) (StARD3) Stard3 Es64 Mln64 Mus musculus (Mouse) 446 lipid transport [GO:0006869]; progesterone biosynthetic process [GO:0006701] GO:0005737; GO:0005739; GO:0005765; GO:0005768; GO:0005770; GO:0006701; GO:0006869; GO:0015485; GO:0016021; GO:0031902 0 0 0 PF10457;PF01852; Q7T2D4 CHOYP_ERGI2.1.2 m.6018 sp ERGI2_DANRE 60.811 74 29 0 1 74 283 356 7.27E-28 107 ERGI2_DANRE reviewed Endoplasmic reticulum-Golgi intermediate compartment protein 2 ergic2 zgc:64005 Danio rerio (Zebrafish) (Brachydanio rerio) 376 vesicle-mediated transport [GO:0016192] GO:0005789; GO:0005794; GO:0016021; GO:0016192; GO:0033116 0 0 0 PF07970; Q7T2H2 CHOYP_FGRL1.2.2 m.45764 sp FGRL1_CHICK 34.314 102 64 2 35 135 249 348 7.27E-13 67.8 FGRL1_CHICK reviewed Fibroblast growth factor receptor-like 1 FGFRL1 Gallus gallus (Chicken) 487 cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; heart valve morphogenesis [GO:0003179]; negative regulation of cell proliferation [GO:0008285]; protein homooligomerization [GO:0051260]; skeletal system development [GO:0001501]; ventricular septum morphogenesis [GO:0060412] GO:0001501; GO:0003179; GO:0005007; GO:0005794; GO:0005886; GO:0008201; GO:0008285; GO:0016021; GO:0030133; GO:0044291; GO:0051260; GO:0060412; GO:0098742 0 0 0 PF07679; Q7ZWG6 CHOYP_LOC100209983.1.1 m.27013 sp PCFT_DANRE 24.923 325 238 4 2 326 128 446 7.27E-28 117 PCFT_DANRE reviewed Proton-coupled folate transporter (Heme carrier protein 1) (PCFT/HCP1) (Solute carrier family 46 member 1) slc46a1 hcp1 pcft zgc:56400 Danio rerio (Zebrafish) (Brachydanio rerio) 481 transmembrane transport [GO:0055085] GO:0005542; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q8JIR0 CHOYP_BMI1A.2.2 m.61273 sp BMI1A_DANRE 54.286 280 106 8 34 310 1 261 7.27E-96 296 BMI1A_DANRE reviewed Polycomb complex protein BMI-1-A (Polycomb group RING finger protein 4-A) bmi1a bmi1 pcgf4a psc1 Danio rerio (Zebrafish) (Brachydanio rerio) 320 "cerebellum development [GO:0021549]; covalent chromatin modification [GO:0016569]; hematopoietic stem cell migration [GO:0035701]; negative regulation of gene expression, epigenetic [GO:0045814]; primitive hemopoiesis [GO:0060215]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0008270; GO:0016569; GO:0021549; GO:0031519; GO:0035701; GO:0045814; GO:0060215; GO:1990841 0 0 0 PF16207; Q96KG7 CHOYP_LOC101075314.1.3 m.55484 sp MEG10_HUMAN 38.43 242 123 11 127 356 432 659 7.27E-28 120 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q99996 CHOYP_LOC100368547.26.40 m.32852 sp AKAP9_HUMAN 38.824 85 43 2 69 148 3584 3664 7.27E-07 50.8 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9JHN8 CHOYP_LOC578120.1.1 m.14872 sp STK19_MOUSE 38.672 256 141 3 3 258 5 244 7.27E-63 200 STK19_MOUSE reviewed Serine/threonine-protein kinase 19 (EC 2.7.11.1) (Protein RP1) Stk19 Rp1 Mus musculus (Mouse) 254 0 GO:0004674; GO:0005524; GO:0005634 0 0 0 PF10494; Q9JLC8 CHOYP_BRAFLDRAFT_67666.2.6 m.32191 sp SACS_MOUSE 21.271 409 269 15 100 473 921 1311 7.27E-11 68.9 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; H2A0N4 CHOYP_PIF.2.6 m.8704 sp PIF_PINMG 26.857 525 338 9 99 591 29 539 7.28E-55 207 PIF_PINMG reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada margaritifera (Black-lipped pearl oyster) 1014 chitin metabolic process [GO:0006030] GO:0005576; GO:0006030; GO:0008061 0 0 0 PF01607;PF00092; O70277 CHOYP_BRAFLDRAFT_69764.7.19 m.24170 sp TRIM3_RAT 25.322 233 133 10 20 233 534 744 7.28E-09 58.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P04755 CHOYP_LOC100533245.1.6 m.24493 sp ACH3_DROME 51.601 281 116 7 1 277 1 265 7.28E-89 276 ACH3_DROME reviewed Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) nAChRbeta1 Acr64B AcrD ard nAcRbeta-64B CG11348 Drosophila melanogaster (Fruit fly) 521 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P34371 CHOYP_NEMVEDRAFT_V1G198958.5.6 m.49593 sp BAT42_CAEEL 28.125 96 67 2 26 120 225 319 7.28E-07 53.5 BAT42_CAEEL reviewed BTB and MATH domain-containing protein 42 bath-42 C50C3.8 Caenorhabditis elegans 410 protein ubiquitination [GO:0016567] GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00651; Q14162 CHOYP_MEG10.86.91 m.64402 sp SREC_HUMAN 36.404 228 133 9 168 394 197 413 7.28E-28 120 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q15853 CHOYP_LOC100552087.1.1 m.26238 sp USF2_HUMAN 52.013 298 79 6 60 314 61 337 7.28E-90 275 USF2_HUMAN reviewed Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2) USF2 BHLHB12 Homo sapiens (Human) 346 lactation [GO:0007595]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000430; GO:0000432; GO:0003700; GO:0003705; GO:0005634; GO:0005654; GO:0006366; GO:0007595; GO:0019086; GO:0042803; GO:0043231; GO:0043425; GO:0043565; GO:0045944; GO:0046982; GO:0055088 0 0 0 PF00010; Q28864 CHOYP_LOC100371332.1.6 m.7760 sp TFPI1_MACMU 40.602 133 65 2 1142 1262 46 176 7.28E-24 107 TFPI1_MACMU reviewed Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) TFPI TFPI1 Macaca mulatta (Rhesus macaque) 304 blood coagulation [GO:0007596] GO:0004867; GO:0005615; GO:0007596; GO:0009986 0 0 0 PF00014; Q4R7H0 CHOYP_LOC578816.1.1 m.49226 sp TTL10_MACFA 46.359 412 188 4 575 953 84 495 7.28E-126 407 TTL10_MACFA reviewed Protein polyglycylase TTLL10 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 10) TTLL10 QtsA-15349 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 618 protein polyglycylation [GO:0018094] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0005930; GO:0015630; GO:0018094; GO:0070735; GO:0070737 0 0 0 PF03133; Q5HYI8 CHOYP_LOC587439.1.1 m.45707 sp RABL3_HUMAN 49.372 239 105 6 3 229 2 236 7.28E-77 234 RABL3_HUMAN reviewed Rab-like protein 3 RABL3 Homo sapiens (Human) 236 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF08477; Q93572 CHOYP_LOC100203038.1.1 m.23128 sp RLA0_CAEEL 62.545 275 103 0 21 295 1 275 7.28E-129 373 RLA0_CAEEL reviewed 60S acidic ribosomal protein P0 rpa-0 F25H2.10 Caenorhabditis elegans 312 cytoplasmic translation [GO:0002181]; ribosome biogenesis [GO:0042254] GO:0002181; GO:0003735; GO:0022625; GO:0030687; GO:0042254; GO:0070180 0 0 0 PF00466; Q9ESN6 CHOYP_TRIM3.13.58 m.20649 sp TRIM2_MOUSE 26.596 188 112 6 70 246 535 707 7.28E-08 56.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9MYX8 CHOYP_DMOJ_GI10747.1.1 m.23320 sp TAU_PAPHA 32.571 175 106 5 2 164 197 371 7.28E-17 79.7 TAU_PAPHA reviewed Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau) MAPT TAU Papio hamadryas (Hamadryas baboon) 383 0 GO:0005829; GO:0005874; GO:0005886; GO:0030424 0 0 0 PF00418; O15027 CHOYP_LOC100695050.1.1 m.19241 sp SC16A_HUMAN 50.905 497 213 10 1013 1488 1227 1713 7.29E-148 513 SC16A_HUMAN reviewed Protein transport protein Sec16A (SEC16 homolog A) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) 2179 COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031]; substantia nigra development [GO:0021762] GO:0000139; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0007029; GO:0015031; GO:0021762; GO:0048208 0 0 0 PF12932;PF12931; P13590 CHOYP_BM1_12515.4.7 m.38822 sp NCAM1_CHICK 25.12 418 257 22 190 585 9 392 7.29E-06 54.3 NCAM1_CHICK reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) 1091 cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167] GO:0005886; GO:0007155; GO:0016021; GO:0030198; GO:0031175; GO:0048167 0 0 0 PF00041;PF07679; P29070 CHOYP_LOC100162079.3.4 m.58507 sp CHS1_NEUCR 26.471 408 221 14 860 1191 374 778 7.29E-22 106 CHS1_NEUCR reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) (Class-III chitin synthase 3) chs-1 B11H24.170 NCU03611 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 917 cell wall organization [GO:0071555]; chitin biosynthetic process [GO:0006031] GO:0004100; GO:0005886; GO:0006031; GO:0016021; GO:0071555 0 0 0 PF01644;PF08407; Q60899 CHOYP_LOC100168796.1.1 m.4672 sp ELAV2_MOUSE 62.865 342 102 6 50 373 22 356 7.29E-143 412 ELAV2_MOUSE reviewed ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Mel-N1) Elavl2 Hub Mus musculus (Mouse) 360 0 GO:0000166; GO:0044822 0 0 0 PF00076; Q641W3 CHOYP_NUFIP1.1.1 m.8979 sp NUFP1_RAT 32.817 323 181 7 250 547 167 478 7.29E-43 164 NUFP1_RAT reviewed Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1) Nufip1 Rattus norvegicus (Rat) 486 box C/D snoRNP assembly [GO:0000492]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein oligomerization [GO:0051259] GO:0000492; GO:0005634; GO:0005726; GO:0005730; GO:0008023; GO:0016363; GO:0022626; GO:0030515; GO:0045944; GO:0046872; GO:0048786; GO:0051259; GO:0070761 0 0 0 PF10453; Q6PAE6 CHOYP_BRAFLDRAFT_121964.1.1 m.61284 sp CE022_XENLA 22.124 452 283 15 80 513 13 413 7.29E-09 61.6 CE022_XENLA reviewed UPF0489 protein C5orf22 homolog 0 Xenopus laevis (African clawed frog) 423 0 0 0 0 0 PF12640; Q8K0U4 CHOYP_BRAFLDRAFT_208436.29.32 m.61624 sp HS12A_MOUSE 31.616 563 315 13 10 515 57 606 7.29E-86 281 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q91XP5 CHOYP_GBRE.1.1 m.22682 sp GLRA3_MOUSE 26.752 157 104 4 25 174 63 215 7.29E-12 67.4 GLRA3_MOUSE reviewed Glycine receptor subunit alpha-3 Glra3 Mus musculus (Mouse) 464 "chloride transmembrane transport [GO:1902476]; glutamate receptor clustering [GO:0097688]; neuropeptide signaling pathway [GO:0007218]; protein homooligomerization [GO:0051260]; response to amino acid [GO:0043200]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0007218; GO:0016594; GO:0016934; GO:0016935; GO:0022852; GO:0030054; GO:0030425; GO:0043200; GO:0043204; GO:0045211; GO:0046872; GO:0051260; GO:0060012; GO:0097688; GO:0098978; GO:0098982; GO:1902476 0 0 0 PF02931;PF02932; Q9JJJ7 CHOYP_LOC577959.2.2 m.51512 sp PORCN_MOUSE 40.343 466 232 10 46 482 12 460 7.29E-103 318 PORCN_MOUSE reviewed Protein-serine O-palmitoleoyltransferase porcupine (mPORC) (EC 2.3.1.-) Porcn Porc Ppn Mus musculus (Mouse) 461 canonical Wnt signaling pathway [GO:0060070]; glycoprotein metabolic process [GO:0009100]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; Wnt signaling pathway [GO:0016055] GO:0005783; GO:0005789; GO:0006497; GO:0008374; GO:0009100; GO:0016055; GO:0017147; GO:0030176; GO:0032281; GO:0045234; GO:0060070; GO:1990698 0 0 0 PF03062; Q9R1R2 CHOYP_BRAFLDRAFT_63830.1.2 m.20161 sp TRIM3_MOUSE 37.5 136 58 6 16 137 22 144 7.29E-13 75.1 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_DACET_2189.1.1 m.61704 sp HMCN1_MOUSE 42.289 201 93 11 107 307 4691 4868 7.30E-36 149 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O55057 CHOYP_PDE6D.1.2 m.6439 sp PDE6D_MOUSE 80.556 144 28 0 4 147 7 150 7.30E-87 253 PDE6D_MOUSE reviewed "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta)" Pde6d Mus musculus (Mouse) 150 phototransduction [GO:0007602]; visual perception [GO:0007601] GO:0005095; GO:0005829; GO:0005856; GO:0007601; GO:0007602; GO:0017137; GO:0030659; GO:0031410; GO:0042995; GO:0047555 0 0 0 PF05351; O55057 CHOYP_PDE6D.2.2 m.27699 sp PDE6D_MOUSE 80.556 144 28 0 4 147 7 150 7.30E-87 253 PDE6D_MOUSE reviewed "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta)" Pde6d Mus musculus (Mouse) 150 phototransduction [GO:0007602]; visual perception [GO:0007601] GO:0005095; GO:0005829; GO:0005856; GO:0007601; GO:0007602; GO:0017137; GO:0030659; GO:0031410; GO:0042995; GO:0047555 0 0 0 PF05351; P53563 CHOYP_ISCW_ISCW012366.1.1 m.3692 sp B2CL1_RAT 30.921 152 96 3 115 258 82 232 7.30E-17 80.5 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; Q01241 CHOYP_NF70.2.4 m.37306 sp NF70_DORPE 43.353 173 88 2 24 192 448 614 7.30E-39 143 NF70_DORPE reviewed 70 kDa neurofilament protein (NF70) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 615 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q01241 CHOYP_NF70.3.4 m.52551 sp NF70_DORPE 43.353 173 88 2 24 192 448 614 7.30E-39 143 NF70_DORPE reviewed 70 kDa neurofilament protein (NF70) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 615 0 GO:0005198; GO:0005882 0 0 0 PF00038; Q0VCJ7 CHOYP_ZGC_110699.1.1 m.867 sp RERG_BOVIN 38.889 162 98 1 10 170 8 169 7.30E-38 133 RERG_BOVIN reviewed Ras-related and estrogen-regulated growth inhibitor RERG Bos taurus (Bovine) 199 negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0005829; GO:0007264; GO:0008285; GO:0009725; GO:0016020; GO:0030308 0 0 0 PF00071; Q24K15 CHOYP_ANGP2.1.5 m.22933 sp ANGP4_BOVIN 41.014 217 117 7 88 298 283 494 7.30E-51 177 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q39565 CHOYP_BRAFLDRAFT_108792.3.5 m.34514 sp DYHB_CHLRE 26.786 1400 909 30 2123 3503 2169 3471 7.30E-155 549 DYHB_CHLRE reviewed "Dynein beta chain, flagellar outer arm" ODA4 ODA-4 SUP1 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4568 cell projection organization [GO:0030030]; microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0016887; GO:0030030; GO:0030286; GO:0031514 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q3U5Q7 CHOYP_LOC100493600.1.1 m.58682 sp CMPK2_MOUSE 46.444 239 119 3 227 463 212 443 7.30E-55 192 CMPK2_MOUSE reviewed "UMP-CMP kinase 2, mitochondrial (EC 2.7.4.14) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Thymidylate kinase LPS-inducible member) (TYKi)" Cmpk2 Tyki Mus musculus (Mouse) 447 cellular response to lipopolysaccharide [GO:0071222]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142] GO:0004127; GO:0004550; GO:0004798; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0006165; GO:0006227; GO:0006233; GO:0006235; GO:0009041; GO:0009142; GO:0033862; GO:0071222 0 0 0 0 Q55E58 CHOYP_BRAFLDRAFT_126447.1.3 m.7127 sp PATS1_DICDI 28.221 163 104 7 1 157 2061 2216 7.30E-09 63.9 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q6ZRF8 CHOYP_LOC100378676.8.8 m.65257 sp RN207_HUMAN 21.078 204 147 6 21 220 101 294 7.30E-08 58.9 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q71R50 CHOYP_DHR11.2.2 m.36445 sp DHR11_CHICK 51.969 254 115 3 1 247 1 254 7.30E-90 268 DHR11_CHICK reviewed Dehydrogenase/reductase SDR family member 11 (EC 1.1.-.-) (Short-chain dehydrogenase/reductase family 24C member 1) DHRS11 SDR24C1 Gallus gallus (Chicken) 255 0 GO:0005576; GO:0016491 0 0 0 PF00106; Q96MM6 CHOYP_HSPA12A.2.27 m.15189 sp HS12B_HUMAN 33.651 630 353 12 9 579 61 684 7.30E-121 375 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9PU85 CHOYP_MDHC.1.1 m.57054 sp PIM3_COTJA 66.038 265 89 1 27 290 32 296 7.30E-130 376 PIM3_COTJA reviewed Serine/threonine-protein kinase pim-3 (EC 2.7.11.1) (qpim) PIM3 PIM-3 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 323 negative regulation of apoptotic process [GO:0043066] GO:0004674; GO:0005524; GO:0005737; GO:0043066 0 0 0 PF00069; A3KNI7 CHOYP_LOC592304.1.1 m.7518 sp CCDB1_DANRE 33.945 327 205 5 11 329 13 336 7.31E-59 196 CCDB1_DANRE reviewed Cyclin-D1-binding protein 1 homolog (Zebrafish homolog of Maid) ccndbp1 zhm zgc:162082 Danio rerio (Zebrafish) (Brachydanio rerio) 344 cell cycle [GO:0007049]; regulation of cell cycle [GO:0051726] GO:0005634; GO:0005737; GO:0007049; GO:0051726 0 0 0 0 O96064 CHOYP_LOC100373653.2.3 m.43047 sp MYSP_MYTGA 60 105 42 0 1 105 71 175 7.31E-35 129 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P79222 CHOYP_CALCR.2.6 m.7058 sp CALCR_RABIT 35.39 308 179 8 1 297 163 461 7.31E-48 171 CALCR_RABIT reviewed Calcitonin receptor (CT-R) CALCR Oryctolagus cuniculus (Rabbit) 474 activation of phospholipase C activity [GO:0007202]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of adenylate cyclase activity [GO:0045762] GO:0004948; GO:0005886; GO:0007166; GO:0007202; GO:0016021; GO:0032841; GO:0045762 0 0 0 PF00002;PF02793; Q01528 CHOYP_contig_013464 m.15424 sp HAAF_LIMPO 38.235 170 98 4 40 208 5 168 7.31E-36 127 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q04998 CHOYP_LOC655286.1.1 m.14490 sp INHBA_MOUSE 24.803 254 146 5 139 366 190 424 7.31E-18 87.8 INHBA_MOUSE reviewed Inhibin beta A chain (Activin beta-A chain) Inhba Mus musculus (Mouse) 424 "activin receptor signaling pathway [GO:0032924]; cell cycle arrest [GO:0007050]; cell development [GO:0048468]; cellular response to cholesterol [GO:0071397]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; endodermal cell differentiation [GO:0035987]; extrinsic apoptotic signaling pathway [GO:0097191]; eyelid development in camera-type eye [GO:0061029]; G1/S transition of mitotic cell cycle [GO:0000082]; GABAergic neuron differentiation [GO:0097154]; growth [GO:0040007]; hair follicle development [GO:0001942]; hematopoietic progenitor cell differentiation [GO:0002244]; hemoglobin biosynthetic process [GO:0042541]; male gonad development [GO:0008584]; mesodermal cell differentiation [GO:0048333]; mesoderm formation [GO:0001707]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of hair follicle development [GO:0051799]; odontogenesis [GO:0042476]; ovarian follicle development [GO:0001541]; palate development [GO:0060021]; positive regulation of cellular protein metabolic process [GO:0032270]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of gene expression [GO:0010628]; positive regulation of ovulation [GO:0060279]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; progesterone secretion [GO:0042701]; regulation of apoptotic process [GO:0042981]; regulation of follicle-stimulating hormone secretion [GO:0046880]; regulation of MAPK cascade [GO:0043408]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to drug [GO:0042493]; SMAD protein signal transduction [GO:0060395]; striatal medium spiny neuron differentiation [GO:0021773]" GO:0000082; GO:0001541; GO:0001707; GO:0001942; GO:0002244; GO:0005102; GO:0005125; GO:0005160; GO:0005576; GO:0005615; GO:0006357; GO:0007050; GO:0008285; GO:0008584; GO:0010628; GO:0010862; GO:0017046; GO:0021773; GO:0030308; GO:0032270; GO:0032924; GO:0035987; GO:0040007; GO:0042476; GO:0042493; GO:0042541; GO:0042701; GO:0042802; GO:0042981; GO:0043408; GO:0043509; GO:0043512; GO:0045648; GO:0045786; GO:0045893; GO:0045944; GO:0046880; GO:0048333; GO:0048468; GO:0048471; GO:0051799; GO:0060021; GO:0060279; GO:0060395; GO:0061029; GO:0070699; GO:0071372; GO:0071397; GO:0097154; GO:0097191; GO:2001241 0 0 0 PF00019;PF00688; Q28062 CHOYP_BRAFLDRAFT_83984.1.2 m.52887 sp PGCB_BOVIN 39.85 133 73 5 38 168 693 820 7.31E-23 97.8 PGCB_BOVIN reviewed Brevican core protein BCAN Bos taurus (Bovine) 912 cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005540; GO:0005578; GO:0007155; GO:0007417; GO:0030246 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; Q3ZBY7 CHOYP_LOC100378209.1.2 m.7336 sp DEGS1_BOVIN 60.938 320 125 0 1 320 1 320 7.31E-154 437 DEGS1_BOVIN reviewed Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Degenerative spermatocyte homolog 1) DEGS1 DES1 Bos taurus (Bovine) 323 ceramide biosynthetic process [GO:0046513]; fatty acid biosynthetic process [GO:0006633] GO:0005739; GO:0005789; GO:0006633; GO:0016021; GO:0042284; GO:0046513 0 0 0 PF00487;PF08557; Q502M6 CHOYP_LOC755521.18.28 m.47700 sp ANR29_DANRE 42 150 87 0 9 158 43 192 7.31E-31 115 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5UQP2 CHOYP_LOC582782.3.4 m.27654 sp YL446_MIMIV 30.348 201 114 5 81 272 55 238 7.31E-19 91.7 YL446_MIMIV reviewed Uncharacterized protein L446 (EC 3.1.1.-) MIMI_L446 Acanthamoeba polyphaga mimivirus (APMV) 332 lipid catabolic process [GO:0016042] GO:0016021; GO:0016042; GO:0016787 0 0 0 PF01734; Q62315 CHOYP_JARID2.1.1 m.32260 sp JARD2_MOUSE 36.458 384 228 7 789 1163 811 1187 7.31E-75 275 JARD2_MOUSE reviewed Protein Jumonji (Jumonji/ARID domain-containing protein 2) Jarid2 Jmj Mus musculus (Mouse) 1234 "covalent chromatin modification [GO:0016569]; liver development [GO:0001889]; negative regulation of cell proliferation [GO:0008285]; negative regulation of histone methylation [GO:0031061]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of histone H3-K9 methylation [GO:0051574]; regulation of cell proliferation [GO:0042127]; spleen development [GO:0048536]; stem cell differentiation [GO:0048863]; thymus development [GO:0048538]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0001227; GO:0001889; GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0008285; GO:0016569; GO:0031061; GO:0035097; GO:0035098; GO:0042127; GO:0045892; GO:0048536; GO:0048538; GO:0048863; GO:0051574 0 0 0 PF01388;PF02373;PF02375;PF02928; Q80Y14 CHOYP_BRAFLDRAFT_129234.1.1 m.10468 sp GLRX5_MOUSE 64.754 122 43 0 25 146 30 151 7.31E-58 179 GLRX5_MOUSE reviewed "Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5)" Glrx5 Mus musculus (Mouse) 152 cell redox homeostasis [GO:0045454]; hemopoiesis [GO:0030097] GO:0005634; GO:0005739; GO:0005759; GO:0009055; GO:0015035; GO:0030097; GO:0030425; GO:0043025; GO:0045454; GO:0046872; GO:0051537 0 0 cd03028; PF00462; Q86TN4 CHOYP_LOC100186294.2.2 m.50742 sp TRPT1_HUMAN 48.402 219 107 3 144 356 4 222 7.31E-61 208 TRPT1_HUMAN reviewed tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) TRPT1 Homo sapiens (Human) 253 "regulation of protein kinase activity [GO:0045859]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]" GO:0000215; GO:0006388; GO:0045859 0 0 0 PF01885; O50655 CHOYP_LOC100635540.5.7 m.36119 sp XERD_SELRU 24.671 304 182 12 14 296 21 298 7.32E-07 53.5 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O60688 CHOYP_YPEL1.2.3 m.39147 sp YPEL1_HUMAN 95.536 112 4 1 3 114 8 118 7.32E-77 225 YPEL1_HUMAN reviewed Protein yippee-like 1 YPEL1 FKSG3 Homo sapiens (Human) 119 0 GO:0005634; GO:0046872 0 0 0 PF03226; P18101 CHOYP_RL40.6.7 m.41217 sp RL40_DROME 90.244 123 10 2 14 135 1 122 7.32E-76 224 RL40_DROME reviewed Ubiquitin-60S ribosomal protein L40 (CEP52) [Cleaved into: Ubiquitin; 60S ribosomal protein L40] RpL40 Ubi-f UBI-F52 CG2960 Drosophila melanogaster (Fruit fly) 128 cellular protein modification process [GO:0006464]; Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567]; translation [GO:0006412]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0003735; GO:0005634; GO:0005829; GO:0005875; GO:0006412; GO:0006464; GO:0006511; GO:0007219; GO:0016567; GO:0022625; GO:0031386 0 0 0 PF01020;PF00240; P33005 CHOYP_LOC100535716.2.3 m.39162 sp KALM_CHICK 50.943 53 24 1 163 213 115 167 7.32E-10 65.1 KALM_CHICK reviewed Anosmin-1 (Kallmann syndrome protein homolog) ANOS1 KAL KAL1 Gallus gallus (Chicken) 675 cell adhesion [GO:0007155] GO:0004867; GO:0005576; GO:0007155; GO:0009986 0 0 0 PF00041;PF00095; P35613 CHOYP_NPTN.1.1 m.50315 sp BASI_HUMAN 30.086 349 170 14 129 439 71 383 7.32E-25 108 BASI_HUMAN reviewed Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147) BSG UNQ6505/PRO21383 Homo sapiens (Human) 385 cell surface receptor signaling pathway [GO:0007166]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; leukocyte migration [GO:0050900]; odontogenesis of dentin-containing tooth [GO:0042475]; protein targeting to plasma membrane [GO:0072661]; pyruvate metabolic process [GO:0006090]; response to cAMP [GO:0051591]; response to mercury ion [GO:0046689]; response to peptide hormone [GO:0043434] GO:0000139; GO:0002080; GO:0005537; GO:0005739; GO:0005886; GO:0005887; GO:0005913; GO:0005925; GO:0006090; GO:0007166; GO:0007566; GO:0008028; GO:0016020; GO:0022617; GO:0030198; GO:0042383; GO:0042470; GO:0042475; GO:0043434; GO:0045121; GO:0046689; GO:0046697; GO:0050900; GO:0051591; GO:0070062; GO:0072661; GO:0098641 0 0 0 0 P41115 CHOYP_LOC100203600.1.1 m.20840 sp RS11_XENLA 75.974 154 36 1 11 163 5 158 7.32E-84 246 RS11_XENLA reviewed 40S ribosomal protein S11 rps11 Xenopus laevis (African clawed frog) 158 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00366;PF16205; Q14315 CHOYP_LOC100369791.1.2 m.8271 sp FLNC_HUMAN 24.921 1585 915 52 19 1411 32 1533 7.32E-90 327 FLNC_HUMAN reviewed Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin) FLNC ABPL FLN2 Homo sapiens (Human) 2725 cell junction assembly [GO:0034329]; muscle fiber development [GO:0048747] GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0008092; GO:0016528; GO:0030018; GO:0030506; GO:0034329; GO:0042383; GO:0043034; GO:0048747 0 0 0 PF00307;PF00630; Q5PQQ9 CHOYP_LOC100370976.2.2 m.27927 sp CEP70_RAT 28.715 599 364 12 36 621 49 597 7.32E-62 219 CEP70_RAT reviewed Centrosomal protein of 70 kDa (Cep70) Cep70 Rattus norvegicus (Rat) 598 0 GO:0005737; GO:0005815 0 0 0 0 Q5R9B8 CHOYP_DCAF6.2.2 m.58401 sp DCAF6_PONAB 58.363 281 112 3 5 280 14 294 7.32E-110 364 DCAF6_PONAB reviewed DDB1- and CUL4-associated factor 6 (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP) DCAF6 IQWD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 860 protein ubiquitination [GO:0016567] GO:0005634; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q8R367 CHOYP_RSLBB.2.2 m.32313 sp RERG_MOUSE 36.508 189 110 6 3 188 5 186 7.32E-29 110 RERG_MOUSE reviewed Ras-related and estrogen-regulated growth inhibitor Rerg Mus musculus (Mouse) 199 negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; response to hormone [GO:0009725]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0005829; GO:0007264; GO:0008285; GO:0009725; GO:0016020; GO:0030308 0 0 0 PF00071; Q96GP6 CHOYP_MEG11.1.25 m.4447 sp SREC2_HUMAN 38.863 211 112 8 325 531 236 433 7.32E-27 119 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9D5I4 CHOYP_ODA-LC2.2.2 m.64460 sp TC1D1_MOUSE 35.714 126 80 1 134 259 49 173 7.32E-19 84.3 TC1D1_MOUSE reviewed Tctex1 domain-containing protein 1 Tctex1d1 Mus musculus (Mouse) 173 0 0 0 0 0 PF03645; O54698 CHOYP_SLC29A3.1.1 m.44150 sp S29A1_RAT 33.691 466 270 9 52 488 2 457 7.33E-82 264 S29A1_RAT reviewed "Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)" Slc29a1 Ent1 Rattus norvegicus (Rat) 457 cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; excitatory postsynaptic potential [GO:0060079]; lactation [GO:0007595]; nucleoside transport [GO:0015858]; sleep [GO:0030431]; uridine transport [GO:0015862] GO:0005337; GO:0005886; GO:0005887; GO:0007595; GO:0015858; GO:0015862; GO:0016323; GO:0016324; GO:0030431; GO:0060079; GO:0071333; GO:0071456; GO:0098794 0 0 0 PF01733; P70460 CHOYP_EVL.1.1 m.57134 sp VASP_MOUSE 37.639 449 199 11 1 445 1 372 7.33E-58 197 VASP_MOUSE reviewed Vasodilator-stimulated phosphoprotein (VASP) Vasp Mus musculus (Mouse) 375 actin cytoskeleton organization [GO:0030036]; actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289]; T cell receptor signaling pathway [GO:0050852] GO:0001843; GO:0005522; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005923; GO:0005925; GO:0007411; GO:0008154; GO:0030027; GO:0030036; GO:0030175; GO:0030838; GO:0031258; GO:0031527; GO:0050852; GO:0051289; GO:0070062 0 0 0 PF08776;PF00568; Q3V0L5 CHOYP_BRAFLDRAFT_125356.3.3 m.35009 sp LRC43_MOUSE 33.225 617 341 14 11 592 27 607 7.33E-71 246 LRC43_MOUSE reviewed Leucine-rich repeat-containing protein 43 Lrrc43 Gm1061 Mus musculus (Mouse) 667 0 0 0 0 0 0 Q6PFR5 CHOYP_TRA2A.1.1 m.21305 sp TRA2A_MOUSE 71.552 116 33 0 204 319 98 213 7.33E-54 182 TRA2A_MOUSE reviewed Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) Tra2a Mus musculus (Mouse) 281 "mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]" GO:0000166; GO:0000398; GO:0003723; GO:0005634; GO:0005730; GO:0042802; GO:0043231; GO:0044822; GO:0048026 0 0 0 PF00076; Q90610 CHOYP_NEO1.2.3 m.36391 sp NEO1_CHICK 35.819 818 417 27 24 769 660 1441 7.33E-117 388 NEO1_CHICK reviewed Neogenin (Fragment) 0 Gallus gallus (Chicken) 1443 axon guidance [GO:0007411]; cell adhesion [GO:0007155]; iron ion homeostasis [GO:0055072]; positive regulation of BMP signaling pathway [GO:0030513] GO:0004872; GO:0005887; GO:0007155; GO:0007411; GO:0030513; GO:0055072 0 0 0 PF00041;PF07679;PF13895;PF06583; Q96DA2 CHOYP_LOC100651946.1.1 m.254 sp RB39B_HUMAN 58.549 193 80 0 2 194 1 193 7.33E-85 253 RB39B_HUMAN reviewed Ras-related protein Rab-39B RAB39B Homo sapiens (Human) 213 protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]; synapse organization [GO:0050808]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005622; GO:0005794; GO:0005886; GO:0007264; GO:0015031; GO:0016192; GO:0031489; GO:0031982; GO:0043005; GO:0050808 0 0 0 PF00071; P28824 CHOYP_BRAFLDRAFT_275083.2.2 m.66603 sp NRP1_XENLA 36.364 110 65 3 37 142 36 144 7.34E-10 62.8 NRP1_XENLA reviewed Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) 928 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; endothelial cell chemotaxis [GO:0035767]; organ morphogenesis [GO:0009887]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005021; GO:0007411; GO:0008201; GO:0009887; GO:0016021; GO:0017154; GO:0035767; GO:0046872; GO:0048010 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; Q02543 CHOYP_RL18A.1.8 m.12900 sp RL18A_HUMAN 70.455 176 52 0 1 176 1 176 7.34E-92 268 RL18A_HUMAN reviewed 60S ribosomal protein L18a RPL18A Homo sapiens (Human) 176 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003723; GO:0003735; GO:0005829; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0044822 0 0 0 PF01775; Q09PK2 CHOYP_CRE_26779.2.2 m.14644 sp APRV1_MOUSE 27.885 104 73 1 2 103 207 310 7.34E-07 52.8 APRV1_MOUSE reviewed Retroviral-like aspartic protease 1 (EC 3.4.23.-) (Skin-specific retroviral-like aspartic protease) (SASPase) (Skin aspartic protease) (TPA-inducible aspartic proteinase-like protein) Asprv1 Sasp Taps Mus musculus (Mouse) 339 protein processing [GO:0016485]; skin development [GO:0043588] GO:0004190; GO:0016021; GO:0016485; GO:0043588 0 0 0 0 Q5JPI3 CHOYP_C3ORF38.1.1 m.59043 sp CC038_HUMAN 32.249 338 183 6 3 337 6 300 7.34E-48 167 CC038_HUMAN reviewed Uncharacterized protein C3orf38 C3orf38 Homo sapiens (Human) 329 apoptotic process [GO:0006915] GO:0006915 0 0 0 PF15008; Q5RB69 CHOYP_BRAFLDRAFT_121069.1.1 m.23764 sp CCD86_PONAB 53.704 108 50 0 20 127 235 342 7.34E-24 97.1 CCD86_PONAB reviewed Coiled-coil domain-containing protein 86 CCDC86 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 360 0 GO:0005634 0 0 0 PF03879; Q5RB69 CHOYP_CCD86.1.1 m.18132 sp CCD86_PONAB 53.704 108 50 0 20 127 235 342 7.34E-24 97.1 CCD86_PONAB reviewed Coiled-coil domain-containing protein 86 CCDC86 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 360 0 GO:0005634 0 0 0 PF03879; Q5RB69 CHOYP_PCKG.1.2 m.43793 sp CCD86_PONAB 53.704 108 50 0 20 127 235 342 7.34E-24 97.1 CCD86_PONAB reviewed Coiled-coil domain-containing protein 86 CCDC86 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 360 0 GO:0005634 0 0 0 PF03879; Q5RDJ2 CHOYP_BRAFLDRAFT_106251.2.6 m.9600 sp ZMYM2_PONAB 28.571 147 91 4 156 297 1101 1238 7.34E-07 55.8 ZMYM2_PONAB reviewed Zinc finger MYM-type protein 2 (Zinc finger protein 198) ZMYM2 ZNF198 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 1377 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270 0 0 0 PF12012;PF06467; Q63170 CHOYP_DNAH7.1.2 m.19685 sp DYH7_RAT 73.5 200 53 0 1 200 1637 1836 7.34E-99 317 DYH7_RAT reviewed "Dynein heavy chain 7, axonemal (Axonemal beta dynein heavy chain 7) (Axonemal dynein heavy chain b) (Ciliary dynein heavy chain 7) (Dynein-like protein 7)" Dnah7 Axob Dlp7 Rattus norvegicus (Rat) 4057 cilium movement [GO:0003341] GO:0003341; GO:0003777; GO:0005509; GO:0005524; GO:0005737; GO:0005858; GO:0005874; GO:0016887 0 0 0 PF12780;PF08393;PF03028;PF12777; Q6H236 CHOYP_NEMVEDRAFT_V1G214844.21.34 m.51040 sp PEG3_BOVIN 27.644 539 348 22 981 1496 1100 1619 7.34E-16 88.6 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6NYI0 CHOYP_HERP2.1.1 m.2778 sp HERP2_DANRE 35.952 420 216 13 3 402 6 392 7.34E-62 207 HERP2_DANRE reviewed Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein herpud2 zgc:56020 zgc:76968 Danio rerio (Zebrafish) (Brachydanio rerio) 397 response to unfolded protein [GO:0006986] GO:0006986; GO:0016021 0 0 0 PF00240; Q7Z5L3 CHOYP_C1QL2.12.32 m.16206 sp C1QL2_HUMAN 31.655 139 90 3 305 440 148 284 7.34E-11 66.2 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q8BX17 CHOYP_GEMIN5.2.2 m.59078 sp GEMI5_MOUSE 31.398 379 229 4 21 397 909 1258 7.34E-48 189 GEMI5_MOUSE reviewed Gem-associated protein 5 (Gemin5) Gemin5 Mus musculus (Mouse) 1502 spliceosomal snRNP assembly [GO:0000387] GO:0000387; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0016020; GO:0016604; GO:0017069; GO:0032797; GO:0034719; GO:0044822 0 0 0 PF12894;PF00400; Q8IPH9 CHOYP_LOC581330.1.1 m.16341 sp SLOB_DROME 32.231 363 213 11 61 403 148 497 7.34E-53 187 SLOB_DROME reviewed Slowpoke-binding protein Slob CG43756 Drosophila melanogaster (Fruit fly) 515 modulation of synaptic transmission [GO:0050804]; negative regulation of ATPase activity [GO:0032780]; negative regulation of ion transport [GO:0043271]; neuromuscular synaptic transmission [GO:0007274]; regulation of glucose metabolic process [GO:0010906]; regulation of membrane potential [GO:0042391]; response to starvation [GO:0042594] GO:0004672; GO:0005737; GO:0005886; GO:0007274; GO:0010906; GO:0032780; GO:0042391; GO:0042594; GO:0043271; GO:0050804 0 0 0 0 Q99PL5 CHOYP_LOC100369294.6.6 m.31225 sp RRBP1_MOUSE 29.038 551 321 14 217 758 856 1345 7.34E-31 135 RRBP1_MOUSE reviewed Ribosome-binding protein 1 (Ribosome receptor protein) (RRp) (mRRp) Rrbp1 Mus musculus (Mouse) 1605 protein transport [GO:0015031]; signal transduction [GO:0007165]; translation [GO:0006412] GO:0004872; GO:0005840; GO:0006412; GO:0007165; GO:0015031; GO:0030176 0 0 0 PF05104; Q9ET66 CHOYP_LOC100892181.1.1 m.49777 sp PI16_MOUSE 41.758 182 91 3 76 255 22 190 7.34E-42 155 PI16_MOUSE reviewed Peptidase inhibitor 16 (PI-16) (Cysteine-rich protease inhibitor) Pi16 Cripi Mus musculus (Mouse) 489 negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052] GO:0005615; GO:0016021; GO:0030414; GO:0061052; GO:0070062 0 0 0 PF00188; Q9I925 CHOYP_LOC100375293.2.2 m.58888 sp FUCL7_ANGJA 31.132 106 62 4 65 164 83 183 7.34E-06 47.4 FUCL7_ANGJA reviewed Fucolectin-7 0 Anguilla japonica (Japanese eel) 189 "regulation of cellular defense response [GO:0010185]; regulation of complement activation, lectin pathway [GO:0001868]; regulation of innate immune response [GO:0045088]" GO:0001868; GO:0005509; GO:0005615; GO:0010185; GO:0030246; GO:0042806; GO:0045088 0 0 0 PF00754; Q9UGM3 CHOYP_DMBT1.13.34 m.27666 sp DMBT1_HUMAN 40.597 771 349 16 18 690 73 832 7.34E-150 490 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; O75074 CHOYP_BRAFLDRAFT_92077.1.1 m.13074 sp LRP3_HUMAN 38.947 95 47 4 123 207 104 197 7.35E-06 51.2 LRP3_HUMAN reviewed Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105) LRP3 Homo sapiens (Human) 770 receptor-mediated endocytosis [GO:0006898] GO:0005905; GO:0006898; GO:0016021 0 0 0 PF00431;PF00057; O88488 CHOYP_PTPRQ.1.8 m.2706 sp PTPRQ_RAT 26.648 1426 809 49 116 1407 942 2264 7.35E-101 361 PTPRQ_RAT reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1) (rPTP-GMC1) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Ptpgmc1 Rattus norvegicus (Rat) 2302 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0005886; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; O88822 CHOYP_SC5D.1.1 m.20739 sp SC5D_MOUSE 64.138 290 100 2 1 287 1 289 7.35E-138 394 SC5D_MOUSE reviewed Lathosterol oxidase (EC 1.14.19.20) (C-5 sterol desaturase) (Delta(7)-sterol 5-desaturase) (Delta(7)-sterol C5(6)-desaturase) (Lathosterol 5-desaturase) (Sterol-C5-desaturase) Sc5d Sc5dl Mus musculus (Mouse) 299 cholesterol biosynthetic process via lathosterol [GO:0033490]; fatty acid biosynthetic process [GO:0006633] GO:0000248; GO:0005506; GO:0005789; GO:0006633; GO:0016021; GO:0033490 0 0 0 PF04116; P02556 CHOYP_LOC373275.1.7 m.4773 sp TBB_LYTPI 97.727 132 3 0 1 132 30 161 7.35E-97 280 TBB_LYTPI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Lytechinus pictus (Painted sea urchin) 177 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P86854 CHOYP_C209A.1.1 m.23496 sp PLCL_MYTGA 29.655 145 95 4 72 215 18 156 7.35E-17 77.8 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q02858 CHOYP_BRAFLDRAFT_99630.8.9 m.47878 sp TIE2_MOUSE 28.367 490 290 14 803 1267 641 1094 7.35E-46 184 TIE2_MOUSE reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b) Tek Hyk Tie-2 Tie2 Mus musculus (Mouse) 1122 angiogenesis [GO:0001525]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; patterning of blood vessels [GO:0001569]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cytokine secretion involved in immune response [GO:0002741]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of endothelial cell proliferation [GO:0001936]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of NIK/NF-kappaB signaling [GO:1901222]; response to retinoic acid [GO:0032526]; single organismal cell-cell adhesion [GO:0016337]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570] GO:0001525; GO:0001569; GO:0001570; GO:0001934; GO:0001935; GO:0001936; GO:0002040; GO:0002741; GO:0004713; GO:0004714; GO:0004872; GO:0005524; GO:0005576; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007160; GO:0007169; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016021; GO:0016323; GO:0016324; GO:0016337; GO:0016525; GO:0018108; GO:0030097; GO:0030334; GO:0030949; GO:0032526; GO:0032878; GO:0033138; GO:0034446; GO:0042307; GO:0043066; GO:0043552; GO:0045121; GO:0045765; GO:0045766; GO:0045785; GO:0046777; GO:0048014; GO:0048471; GO:0050900; GO:0051259; GO:0051894; GO:0051897; GO:0060347; GO:0070374; GO:1901222; GO:1902533; GO:2000251; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q1MTN8 CHOYP_LOC100891594.2.2 m.54602 sp ACL4_SCHPO 29.801 302 169 7 28 309 26 304 7.35E-33 129 ACL4_SCHPO reviewed Probable assembly chaperone of rpl4 SPBC16D10.01c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 336 ribosome biogenesis [GO:0042254] GO:0005634; GO:0005730; GO:0005737; GO:0042254; GO:0043234 0 0 0 PF13181; Q4G0N8 CHOYP_LOC100371138.1.1 m.46825 sp SL9C1_HUMAN 27.063 1127 761 24 47 1153 27 1112 7.35E-133 444 SL9C1_HUMAN reviewed Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 9 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE) SLC9C1 SLC9A10 Homo sapiens (Human) 1177 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; potassium ion transmembrane transport [GO:0071805]; regulation of intracellular pH [GO:0051453]; sodium ion import across plasma membrane [GO:0098719]; spermatogenesis [GO:0007283]; sperm motility [GO:0030317] GO:0005886; GO:0007275; GO:0007283; GO:0015385; GO:0015386; GO:0016021; GO:0030154; GO:0030317; GO:0031514; GO:0051453; GO:0071805; GO:0098719 0 0 0 PF00027;PF00520;PF00999; Q502M6 CHOYP_AOR_1_1386094.5.6 m.32945 sp ANR29_DANRE 41.322 121 71 0 4 124 59 179 7.35E-24 95.9 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q6PFY8 CHOYP_LOC100370588.8.19 m.32251 sp TRI45_MOUSE 22.909 275 185 12 4 260 127 392 7.35E-06 52.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8SWR3 CHOYP_ISCW_ISCW008779.1.1 m.4143 sp SPR_DROME 25.263 380 252 12 2 362 41 407 7.35E-14 76.3 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q91677 CHOYP_GATA4.2.2 m.11487 sp GATA4_XENLA 40.483 331 130 17 100 382 1 312 7.35E-47 170 GATA4_XENLA reviewed Transcription factor GATA-4 (GATA-binding factor 4) (xGATA-4) gata4 Xenopus laevis (African clawed frog) 392 "cardiac muscle tissue development [GO:0048738]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0008270; GO:0043565; GO:0044212; GO:0045893; GO:0045944; GO:0048738 0 0 0 PF00320;PF05349; Q92626 CHOYP_CNTN4.1.2 m.51939 sp PXDN_HUMAN 27.273 242 143 11 267 497 397 616 7.35E-09 63.5 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; A7M7B9 CHOYP_LOC763904.1.2 m.3349 sp NTH_CHICK 61.753 251 89 2 42 291 35 279 7.36E-111 326 NTH_CHICK reviewed Endonuclease III-like protein 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycoslyase/AP lyase) NTHL1 Gallus gallus (Chicken) 281 "base-excision repair, AP site formation [GO:0006285]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792]" GO:0000703; GO:0002230; GO:0003690; GO:0005634; GO:0005739; GO:0006285; GO:0006296; GO:0046872; GO:0051539; GO:0098779; GO:0098792 0 0 cd00056; PF00633;PF00730; O75691 CHOYP_UTP20.3.4 m.18601 sp UTP20_HUMAN 40.051 392 182 3 1 392 831 1169 7.36E-76 259 UTP20_HUMAN reviewed Small subunit processome component 20 homolog (Down-regulated in metastasis protein) (Novel nucleolar protein 73) (NNP73) (Protein Key-1A6) UTP20 DRIM Homo sapiens (Human) 2785 "endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000472]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of cell proliferation [GO:0008285]; rRNA processing [GO:0006364]" GO:0000447; GO:0000462; GO:0000472; GO:0000480; GO:0005654; GO:0005730; GO:0005737; GO:0006364; GO:0008285; GO:0030686; GO:0030688; GO:0032040; GO:0044822 0 0 0 PF07539; P33267 CHOYP_LOC101155419.1.1 m.2525 sp CP2F2_MOUSE 36.933 463 281 7 29 487 29 484 7.36E-98 306 CP2F2_MOUSE reviewed Cytochrome P450 2F2 (EC 1.14.14.-) (CYPIIF2) (Cytochrome P450-NAH-2) (Naphthalene dehydrogenase) (Naphthalene hydroxylase) Cyp2f2 Cyp2f-2 Mus musculus (Mouse) 491 epoxygenase P450 pathway [GO:0019373]; naphthalene metabolic process [GO:0018931]; response to toxic substance [GO:0009636]; trichloroethylene metabolic process [GO:0018979] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0009636; GO:0016712; GO:0018931; GO:0018979; GO:0019373; GO:0019825; GO:0020037; GO:0031090; GO:0043231 0 0 0 PF00067; P35224 CHOYP_LOC100533383.2.2 m.18661 sp CTNB_URECA 89.674 184 19 0 1 184 121 304 7.36E-109 333 CTNB_URECA reviewed Catenin beta (Beta-catenin) 0 Urechis caupo (Innkeeper worm) (Spoonworm) 818 adherens junction assembly [GO:0034333]; cell adhesion [GO:0007155] GO:0004871; GO:0005737; GO:0005856; GO:0007155; GO:0034333 0 0 0 PF00514; P97411 CHOYP_LOC100373653.2.3 m.43040 sp ICA69_MOUSE 70.098 204 61 0 4 207 79 282 7.36E-100 302 ICA69_MOUSE reviewed Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) Ica1 Icap69 Mus musculus (Mouse) 478 neurotransmitter transport [GO:0006836]; regulation of insulin secretion [GO:0050796]; regulation of neurotransmitter secretion [GO:0046928]; regulation of protein homodimerization activity [GO:0043496] GO:0000139; GO:0005737; GO:0005794; GO:0005795; GO:0005829; GO:0006836; GO:0030054; GO:0030425; GO:0030667; GO:0030672; GO:0043496; GO:0046928; GO:0048471; GO:0050796 0 0 0 PF06456;PF04629; Q14642 CHOYP_LOC662279.1.1 m.38829 sp I5P1_HUMAN 50.636 393 187 5 6 393 10 400 7.36E-137 409 I5P1_HUMAN reviewed "Type I inositol 1,4,5-trisphosphate 5-phosphatase (5PTase) (EC 3.1.3.56)" INPP5A Homo sapiens (Human) 412 inositol phosphate metabolic process [GO:0043647]; phosphatidylinositol dephosphorylation [GO:0046856] GO:0004445; GO:0005886; GO:0016020; GO:0042731; GO:0043647; GO:0046856; GO:0052658; GO:0052659; GO:0070062 0 0 0 0 Q32PI8 CHOYP_ISCW_ISCW017652.1.1 m.49306 sp RT27_BOVIN 24.48 433 277 12 6 421 7 406 7.36E-22 100 RT27_BOVIN reviewed "28S ribosomal protein S27, mitochondrial (MRP-S27) (S27mt)" MRPS27 Bos taurus (Bovine) 415 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0005739; GO:0005743; GO:0005840; GO:0070124; GO:0070125 0 0 0 PF10037; Q84WJ2 CHOYP_LOC100889028.1.1 m.18591 sp PRI2_ARATH 29.062 437 242 16 3 414 24 417 7.36E-34 137 PRI2_ARATH reviewed Probable DNA primase large subunit (EC 2.7.7.-) At1g67320 F1N21_14 Arabidopsis thaliana (Mouse-ear cress) 454 0 GO:0003677; GO:0003896; GO:0046872; GO:0051539; GO:1990077 0 0 cd07322; PF04104; Q8JHV9 CHOYP_TIAP2.5.13 m.38206 sp BIR7A_XENLA 31.864 295 160 7 67 356 139 397 7.36E-43 156 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q99M85 CHOYP_LOC101063123.1.1 m.10564 sp SCRT1_MOUSE 77.922 154 34 0 144 297 191 344 7.36E-87 266 SCRT1_MOUSE reviewed Transcriptional repressor scratch 1 (Scratch homolog 1 zinc finger protein) (SCRT) (Scratch 1) (mScrt) Scrt1 Mus musculus (Mouse) 348 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of neuron migration [GO:2001222]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0005634; GO:0006351; GO:0046872; GO:2001222 0 0 0 PF00096;PF13912; Q9JIL5 CHOYP_DPSE_GA18988.1.1 m.630 sp TULP4_MOUSE 44.818 685 316 20 1 636 1 672 7.36E-163 525 TULP4_MOUSE reviewed Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4) Tulp4 Tusp Mus musculus (Mouse) 1547 intracellular signal transduction [GO:0035556]; protein localization to cilium [GO:0061512]; protein ubiquitination [GO:0016567] GO:0005737; GO:0005929; GO:0016567; GO:0035091; GO:0035556; GO:0061512 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF01167; A7Z035 CHOYP_EPN4.3.3 m.66576 sp EPN4_BOVIN 38.345 725 296 29 1 659 4 643 7.37E-103 330 EPN4_BOVIN reviewed Clathrin interactor 1 (Epsin-4) CLINT1 EPN4 Bos taurus (Bovine) 643 endocytosis [GO:0006897] GO:0005654; GO:0005798; GO:0005802; GO:0006897; GO:0008289; GO:0016020; GO:0030136; GO:0048471 0 0 0 PF01417; P0C0A9 CHOYP_LOC100376864.2.4 m.20389 sp SVIP_RAT 42.5 80 42 2 25 104 1 76 7.37E-10 53.9 SVIP_RAT reviewed Small VCP/p97-interacting protein Svip Rattus norvegicus (Rat) 76 "negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly [GO:1904240]; positive regulation of autophagy [GO:0010508]; positive regulation of protein lipidation [GO:1903061]" GO:0000139; GO:0005886; GO:0010508; GO:0030868; GO:0031225; GO:0036513; GO:0070062; GO:1903061; GO:1903070; GO:1904153; GO:1904240 0 0 0 PF15811; Q12802 CHOYP_AKP13.1.5 m.12951 sp AKP13_HUMAN 29.369 967 540 33 780 1676 1790 2683 7.37E-90 330 AKP13_HUMAN reviewed A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47) AKAP13 BRX HT31 LBC Homo sapiens (Human) 2813 adrenergic receptor signaling pathway [GO:0071875]; adrenergic receptor signaling pathway involved in heart process [GO:0086023]; bone development [GO:0060348]; cardiac muscle cell differentiation [GO:0055007]; G-protein coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular signal transduction [GO:0035556]; nuclear export [GO:0051168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Rho protein signal transduction [GO:0035025]; regulation of cardiac muscle hypertrophy [GO:0010611]; regulation of glucocorticoid mediated signaling pathway [GO:1900169]; regulation of protein kinase activity [GO:0045859]; regulation of sarcomere organization [GO:0060297]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004691; GO:0004871; GO:0005078; GO:0005085; GO:0005089; GO:0005634; GO:0005737; GO:0005829; GO:0005938; GO:0007186; GO:0007507; GO:0010611; GO:0016020; GO:0017048; GO:0032947; GO:0035025; GO:0035556; GO:0043065; GO:0043123; GO:0045859; GO:0046872; GO:0048471; GO:0051018; GO:0051056; GO:0051168; GO:0055007; GO:0060297; GO:0060348; GO:0071875; GO:0086023; GO:1900169 0 0 0 PF00169;PF00621;PF10522; Q502M6 CHOYP_RL18A.5.8 m.44788 sp ANR29_DANRE 39.394 132 80 0 5 136 76 207 7.37E-26 102 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5NBX1 CHOYP_LOC100371115.1.1 m.17166 sp COBL_MOUSE 38.571 70 43 0 73 142 58 127 7.37E-07 52 COBL_MOUSE reviewed Protein cordon-bleu Cobl Kiaa0633 Mus musculus (Mouse) 1337 actin crosslink formation [GO:0051764]; actin filament network formation [GO:0051639]; actin filament polymerization [GO:0030041]; collateral sprouting in absence of injury [GO:0048669]; digestive tract development [GO:0048565]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; liver development [GO:0001889]; neural tube closure [GO:0001843]; notochord development [GO:0030903]; positive regulation of dendrite development [GO:1900006]; positive regulation of ruffle assembly [GO:1900029]; somite specification [GO:0001757] GO:0000578; GO:0001726; GO:0001757; GO:0001843; GO:0001889; GO:0003785; GO:0005856; GO:0005886; GO:0005938; GO:0030041; GO:0030424; GO:0030425; GO:0030903; GO:0033504; GO:0043025; GO:0044294; GO:0044295; GO:0048471; GO:0048565; GO:0048669; GO:0051639; GO:0051764; GO:1900006; GO:1900029 0 0 0 PF09469;PF02205; Q5RBQ7 CHOYP_CDO1.4.4 m.58234 sp CDO1_PONAB 44.828 174 90 1 25 198 29 196 7.37E-47 155 CDO1_PONAB reviewed Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I) CDO1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 200 taurine biosynthetic process [GO:0042412] GO:0005506; GO:0005829; GO:0017172; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. 0 0 PF05995; Q6P069 CHOYP_LOC100554313.1.1 m.20949 sp SORCN_MOUSE 35.979 189 100 6 58 246 31 198 7.37E-29 110 SORCN_MOUSE reviewed Sorcin Sri Mus musculus (Mouse) 198 calcium ion transport [GO:0006816]; cytoplasmic sequestering of transcription factor [GO:0042994]; heart development [GO:0007507]; negative regulation of heart rate [GO:0010459]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of relaxation of muscle [GO:1901077] GO:0002020; GO:0004198; GO:0005509; GO:0005622; GO:0005654; GO:0005737; GO:0005739; GO:0005789; GO:0005790; GO:0005829; GO:0005886; GO:0006508; GO:0006816; GO:0007507; GO:0010459; GO:0016020; GO:0030018; GO:0030315; GO:0031982; GO:0033017; GO:0035774; GO:0042584; GO:0042994; GO:0043679; GO:0044326; GO:0046982; GO:0051281; GO:0051924; GO:0060315; GO:0070062; GO:0070491; GO:0086004; GO:1901077; GO:1901841; GO:1901844; GO:2000678 0 0 0 PF13405;PF13833; Q6V0I7 CHOYP_BRAFLDRAFT_133692.3.4 m.52556 sp FAT4_HUMAN 27.187 423 281 15 397 808 684 1090 7.37E-17 90.1 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q8BX70 CHOYP_BRAFLDRAFT_88208.1.3 m.2572 sp VP13C_MOUSE 29.808 1305 760 33 2196 3459 2522 3711 7.37E-143 508 VP13C_MOUSE reviewed Vacuolar protein sorting-associated protein 13C Vps13c Kiaa3021 Mus musculus (Mouse) 3748 mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0005741; GO:0005829; GO:0006623; GO:0007005; GO:0019898; GO:0045053; GO:0070062; GO:1905090 0 0 0 PF09333;PF12624;PF06650;PF16908;PF16909;PF16910; Q8C5V5 CHOYP_LOC580145.1.1 m.13117 sp WDR27_MOUSE 34.574 376 177 7 21 360 386 728 7.37E-57 201 WDR27_MOUSE reviewed WD repeat-containing protein 27 Wdr27 Mus musculus (Mouse) 780 0 GO:0005654 0 0 0 PF00400; Q8VHI7 CHOYP_LOC100369421.2.2 m.38203 sp CCD65_MOUSE 62.353 85 32 0 17 101 16 100 7.37E-27 105 CCD65_MOUSE reviewed Coiled-coil domain-containing protein 65 (Testis development protein NYD-SP28) Ccdc65 Mus musculus (Mouse) 493 0 0 0 0 0 0 Q95P23 CHOYP_KPOL_133P1.1.2 m.13098 sp ENPP_APLCA 24.528 212 160 0 121 332 341 552 7.37E-19 91.3 ENPP_APLCA reviewed Enterin neuropeptides [Cleaved into: ENa; ENb; ENc; ENd; ENe; ENf; ENg; ENh; ENi; ENj; ENk; ENl; ENm; ENn; ENo; ENp; ENq; ENr; ENs; ENt] ENPP Aplysia californica (California sea hare) 837 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 0 Q9H8M1 CHOYP_COQ10B.1.1 m.59337 sp CQ10B_HUMAN 61.446 166 63 1 72 237 66 230 7.37E-71 219 CQ10B_HUMAN reviewed "Coenzyme Q-binding protein COQ10 homolog B, mitochondrial" COQ10B Homo sapiens (Human) 238 0 GO:0005743 0 0 0 PF03364; Q9QX47 CHOYP_LOC655899.1.1 m.13802 sp SON_MOUSE 40 85 49 1 6 90 2234 2316 7.37E-14 69.7 SON_MOUSE reviewed Protein SON (Negative regulatory element-binding protein) (NRE-binding protein) Son Nrebp Mus musculus (Mouse) 2444 "microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000226; GO:0000281; GO:0003677; GO:0003723; GO:0005654; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0016607; GO:0043066; GO:0043484; GO:0044822; GO:0048024; GO:0050733; GO:0051726; GO:0071011 0 0 0 PF01585; Q9ULI1 CHOYP_K1239.3.3 m.45453 sp NWD2_HUMAN 29.297 925 594 23 21 897 35 947 7.37E-109 388 NWD2_HUMAN reviewed NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 0 0 0 0 0 PF13271; Q9Y6D9 CHOYP_LOC591426.1.1 m.19354 sp MD1L1_HUMAN 31.671 742 465 13 1 725 1 717 7.37E-91 302 MD1L1_HUMAN reviewed Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181) MAD1L1 MAD1 TXBP181 Homo sapiens (Human) 718 cell division [GO:0051301]; mitotic cell cycle checkpoint [GO:0007093]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of T cell proliferation [GO:0042130]; regulation of metaphase plate congression [GO:0090235]; sister chromatid cohesion [GO:0007062]; thymus development [GO:0048538] GO:0000776; GO:0000777; GO:0000922; GO:0005634; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0007062; GO:0007067; GO:0007093; GO:0007094; GO:0015629; GO:0042130; GO:0048538; GO:0051301; GO:0072686; GO:0090235 0 0 0 PF05557; A1A4Q2 CHOYP_LOC575671.1.1 m.15507 sp PRXD1_BOVIN 43.86 171 92 4 1 169 1 169 7.38E-42 140 PRXD1_BOVIN reviewed Prolyl-tRNA synthetase associated domain-containing protein 1 (PrdX deacylase domain-containing protein 1) PRORSD1 PRDXDD1 Bos taurus (Bovine) 171 0 GO:0002161 0 0 0 PF04073; A4IFD0 CHOYP_AK5.1.2 m.7331 sp KAD5_BOVIN 50 56 27 1 9 63 5 60 7.38E-12 63.9 KAD5_BOVIN reviewed Adenylate kinase isoenzyme 5 (AK 5) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 5) Ak5 Bos taurus (Bovine) 562 ATP metabolic process [GO:0046034]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142] GO:0004017; GO:0004550; GO:0005524; GO:0005737; GO:0005815; GO:0006165; GO:0009142; GO:0046034 0 0 cd01428; 0 O02467 CHOYP_ASPG.2.2 m.64171 sp ASPG_SPOFR 52.454 326 143 2 23 347 6 320 7.38E-118 347 ASPG_SPOFR reviewed N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (AGA) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain] (Fragment) 0 Spodoptera frugiperda (Fall armyworm) 320 0 GO:0003948; GO:0005764; GO:0008233 0 0 0 PF01112; O43511 CHOYP_LOC100552593.3.3 m.62025 sp S26A4_HUMAN 33.162 778 468 12 9 777 6 740 7.38E-133 416 S26A4_HUMAN reviewed Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4) SLC26A4 PDS Homo sapiens (Human) 780 bicarbonate transport [GO:0015701]; inorganic anion transport [GO:0015698]; ion transport [GO:0006811]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; regulation of pH [GO:0006885]; regulation of protein localization [GO:0032880]; sensory perception of sound [GO:0007605]; sulfate transport [GO:0008272] GO:0005254; GO:0005886; GO:0005887; GO:0006811; GO:0006885; GO:0007605; GO:0008271; GO:0008272; GO:0015106; GO:0015108; GO:0015111; GO:0015116; GO:0015301; GO:0015698; GO:0015701; GO:0016021; GO:0016324; GO:0019531; GO:0031526; GO:0032880; GO:0042391; GO:0051453; GO:0070062 0 0 0 PF01740;PF00916; O62640 CHOYP_TIAP2.6.13 m.47817 sp PIAP_PIG 35.862 290 163 8 294 577 86 358 7.38E-51 182 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; O95475 CHOYP_SIX3.1.1 m.45504 sp SIX6_HUMAN 74.39 246 51 2 1 234 1 246 7.38E-126 360 SIX6_HUMAN reviewed Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) SIX6 OPTX2 SIX9 Homo sapiens (Human) 246 eye development [GO:0001654]; organ morphogenesis [GO:0009887]; visual perception [GO:0007601] GO:0001205; GO:0001654; GO:0003677; GO:0005634; GO:0007601; GO:0009887 0 0 0 PF00046;PF16878; P18288 CHOYP_LOC100366892.2.3 m.51427 sp TBAT_ONCMY 44.444 126 48 4 26 141 71 184 7.38E-08 53.5 TBAT_ONCMY reviewed "Tubulin alpha chain, testis-specific [Cleaved into: Detyrosinated tubulin alpha chain, testis-specific]" 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P23800 CHOYP_LOC574943.1.1 m.56446 sp RCC1_MESAU 55.462 119 52 1 10 127 299 417 7.38E-40 140 RCC1_MESAU reviewed Regulator of chromosome condensation (Chromosome condensation protein 1) RCC1 CHC1 Mesocricetus auratus (Golden hamster) 421 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0005085; GO:0005634; GO:0005737; GO:0007059; GO:0007067; GO:0031492; GO:0051225; GO:0051301 0 0 0 PF00415; P36406 CHOYP_TVAG_473790.1.1 m.64623 sp TRI23_HUMAN 21.818 275 179 10 2 243 124 395 7.38E-07 54.3 TRI23_HUMAN reviewed E3 ubiquitin-protein ligase TRIM23 (EC 6.3.2.-) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23) TRIM23 ARD1 ARFD1 RNF46 Homo sapiens (Human) 574 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264]; viral process [GO:0016032] GO:0000139; GO:0003924; GO:0004842; GO:0005525; GO:0005634; GO:0005765; GO:0007264; GO:0008047; GO:0008270; GO:0016032; GO:0016567; GO:0016874; GO:0019003; GO:0042802; GO:0070062 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF14634; Q08431 CHOYP_LOC590438.1.1 m.47777 sp MFGM_HUMAN 30.882 204 119 10 183 366 24 225 7.38E-15 78.6 MFGM_HUMAN reviewed Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] MFGE8 Homo sapiens (Human) 387 "angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cellular protein metabolic process [GO:0044267]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of apoptotic cell clearance [GO:2000427]; positive regulation of cell proliferation [GO:0008284]; response to estrogen [GO:0043627]; single fertilization [GO:0007338]; viral process [GO:0016032]" GO:0001525; GO:0001786; GO:0005576; GO:0005615; GO:0006910; GO:0006911; GO:0007155; GO:0007338; GO:0008284; GO:0008429; GO:0009897; GO:0016020; GO:0016032; GO:0019897; GO:0043627; GO:0044267; GO:0070062; GO:1903561; GO:2000427 0 0 0 PF00008;PF00754; Q25145 CHOYP_TPM2.3.8 m.5908 sp TPM_HALRU 84.667 150 23 0 6 155 123 272 7.38E-76 230 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q28685 CHOYP_LOC100027899.1.1 m.2100 sp DAG1_RABIT 23.028 317 219 5 157 451 491 804 7.38E-19 94 DAG1_RABIT reviewed Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] DAG1 Oryctolagus cuniculus (Rabbit) 895 basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; commissural neuron axon guidance [GO:0071679]; cytoskeletal anchoring at plasma membrane [GO:0007016]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; intracellular signal transduction [GO:0035556]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; modulation by virus of host morphology or physiology [GO:0019048]; morphogenesis of an epithelial sheet [GO:0002011]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of protein kinase B signaling [GO:0051898]; nerve maturation [GO:0021682]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470] GO:0002011; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005654; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0005925; GO:0006509; GO:0006607; GO:0007016; GO:0008307; GO:0009279; GO:0010470; GO:0010717; GO:0016010; GO:0016011; GO:0016021; GO:0019048; GO:0021682; GO:0022011; GO:0030027; GO:0030175; GO:0030336; GO:0033268; GO:0034453; GO:0035556; GO:0042383; GO:0043237; GO:0043409; GO:0045121; GO:0045211; GO:0051898; GO:0060441; GO:0060445; GO:0070062; GO:0070938; GO:0071679; GO:0071711; GO:1904261 0 0 0 PF05454; Q5RB77 CHOYP_PDCL3.1.1 m.7323 sp PDCL3_PONAB 60.084 238 94 1 1 238 1 237 7.38E-103 301 PDCL3_PONAB reviewed Phosducin-like protein 3 PDCL3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 239 angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; viral process [GO:0016032] GO:0001525; GO:0005737; GO:0006915; GO:0016032 0 0 0 PF02114; Q8C206 CHOYP_GP157.2.2 m.49084 sp GP157_MOUSE 27.468 233 151 7 92 317 79 300 7.38E-14 75.1 GP157_MOUSE reviewed Probable G-protein coupled receptor 157 Gpr157 Mus musculus (Mouse) 330 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021 0 0 0 PF00002; Q8IVG5 CHOYP_BRAFLDRAFT_131039.8.9 m.56358 sp SAM9L_HUMAN 24.925 333 201 14 316 618 687 1000 7.38E-10 67.4 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q95R48 CHOYP_CPIPJ_CPIJ001657.1.2 m.45384 sp OCTL_DROME 29.167 432 272 12 1 419 1 411 7.38E-42 158 OCTL_DROME reviewed Organic cation transporter-like protein Orct2 CG13610 Drosophila melanogaster (Fruit fly) 567 germ-band shortening [GO:0007390]; organic cation transport [GO:0015695]; positive regulation of cell growth [GO:0030307]; positive regulation of multicellular organism growth [GO:0040018] GO:0005887; GO:0007390; GO:0015101; GO:0015695; GO:0022891; GO:0030307; GO:0040018 0 0 cd06174; PF00083; Q9D4D4 CHOYP_LOC101069588.1.1 m.34190 sp TKTL2_MOUSE 69.534 279 85 0 1 279 343 621 7.38E-135 397 TKTL2_MOUSE reviewed Transketolase-like protein 2 (EC 2.2.1.1) Tktl2 Mus musculus (Mouse) 627 metabolic process [GO:0008152] GO:0004802; GO:0005737; GO:0008152; GO:0046872 0 0 0 PF02779;PF02780;PF00456; Q9NQQ7 CHOYP_S35C2.1.1 m.39766 sp S35C2_HUMAN 55.625 320 140 1 34 353 9 326 7.38E-119 352 S35C2_HUMAN reviewed Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein) SLC35C2 C20orf5 OVCOV1 CGI-15 Homo sapiens (Human) 365 negative regulation of gene expression [GO:0010629]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked fucosylation [GO:0036066]; UDP-glucose transport [GO:0015786] GO:0005793; GO:0005794; GO:0005801; GO:0010629; GO:0015786; GO:0016021; GO:0033116; GO:0036066; GO:0045747 0 0 0 PF03151; Q9NRL2 CHOYP_BRAFLDRAFT_216893.1.1 m.18940 sp BAZ1A_HUMAN 46.988 166 87 1 17 182 531 695 7.38E-40 149 BAZ1A_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) BAZ1A ACF1 WCRF180 HSPC317 Homo sapiens (Human) 1556 "chromatin remodeling [GO:0006338]; DNA-dependent DNA replication [GO:0006261]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006261; GO:0006338; GO:0006351; GO:0006355; GO:0008270; GO:0008623; GO:0016590 0 0 0 PF00439;PF02791;PF00628;PF10537;PF15612;PF15613; Q9P104 CHOYP_DOK5.1.1 m.44392 sp DOK5_HUMAN 30.837 227 130 7 17 223 8 227 7.38E-24 100 DOK5_HUMAN reviewed Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6) DOK5 C20orf180 Homo sapiens (Human) 306 MAPK cascade [GO:0000165]; nervous system development [GO:0007399]; regulation of neurotrophin TRK receptor signaling pathway [GO:0051386]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000165; GO:0005057; GO:0005622; GO:0007169; GO:0007399; GO:0051386 0 0 0 PF02174; Q9R1R2 CHOYP_BRAFLDRAFT_87322.1.10 m.8476 sp TRIM3_MOUSE 25.833 120 88 1 48 167 625 743 7.38E-06 49.7 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; D3YXG0 CHOYP_HMCN1.23.44 m.42684 sp HMCN1_MOUSE 23.148 2065 1243 97 3793 5726 1374 3225 7.39E-73 278 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; P08483 CHOYP_ACM3.1.1 m.36039 sp ACM3_RAT 22.361 559 328 19 2 491 40 561 7.39E-13 74.3 ACM3_RAT reviewed Muscarinic acetylcholine receptor M3 Chrm3 Chrm-3 Rattus norvegicus (Rat) 589 "adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway [GO:0007197]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway [GO:0007207]; positive regulation of smooth muscle contraction [GO:0045987]; regulation of vascular smooth muscle contraction [GO:0003056]; regulation of vasoconstriction [GO:0019229]; saliva secretion [GO:0046541]; smooth muscle contraction [GO:0006939]; synaptic transmission, cholinergic [GO:0007271]" GO:0003056; GO:0005886; GO:0005887; GO:0006939; GO:0007197; GO:0007207; GO:0007213; GO:0007271; GO:0008144; GO:0016323; GO:0016907; GO:0019229; GO:0030054; GO:0030425; GO:0032279; GO:0042166; GO:0043679; GO:0045211; GO:0045987; GO:0046541 0 0 0 PF00001; P18075 CHOYP_LOC100650311.1.1 m.51694 sp BMP7_HUMAN 37.5 424 248 7 5 417 14 431 7.39E-95 294 BMP7_HUMAN reviewed Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) (Eptotermin alfa) BMP7 OP1 Homo sapiens (Human) 431 "axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of an epithelial tube [GO:0048754]; cartilage development [GO:0051216]; cellular response to BMP stimulus [GO:0071773]; cellular response to hypoxia [GO:0071456]; dendrite development [GO:0016358]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint morphogenesis [GO:0060272]; epithelial cell differentiation [GO:0030855]; epithelial to mesenchymal transition [GO:0001837]; growth [GO:0040007]; mesenchymal cell differentiation [GO:0048762]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; mesonephros development [GO:0001823]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephric mesenchyme morphogenesis [GO:0072133]; metanephros development [GO:0001656]; monocyte aggregation [GO:0070487]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell death [GO:0060548]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:0072040]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; negative regulation of transcription, DNA-templated [GO:0045892]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neuron projection morphogenesis [GO:0048812]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of dendrite development [GO:1900006]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of hyaluranon cable assembly [GO:1900106]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization to nucleus [GO:0034504]; regulation of apoptotic process [GO:0042981]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393]; regulation of removal of superoxide radicals [GO:2000121]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]; skeletal system development [GO:0001501]; SMAD protein signal transduction [GO:0060395]; steroid hormone mediated signaling pathway [GO:0043401]; ureteric bud development [GO:0001657]" GO:0001501; GO:0001503; GO:0001656; GO:0001657; GO:0001707; GO:0001823; GO:0001837; GO:0005125; GO:0005160; GO:0005576; GO:0005615; GO:0007411; GO:0008201; GO:0009880; GO:0010664; GO:0010800; GO:0010862; GO:0016358; GO:0030326; GO:0030501; GO:0030509; GO:0030855; GO:0031012; GO:0031988; GO:0032088; GO:0032355; GO:0033280; GO:0034116; GO:0034504; GO:0040007; GO:0042326; GO:0042347; GO:0042475; GO:0042981; GO:0043065; GO:0043401; GO:0043407; GO:0043434; GO:0045665; GO:0045669; GO:0045746; GO:0045786; GO:0045839; GO:0045892; GO:0045893; GO:0045944; GO:0048596; GO:0048754; GO:0048762; GO:0048812; GO:0051216; GO:0060272; GO:0060393; GO:0060395; GO:0060445; GO:0060485; GO:0060548; GO:0060686; GO:0060687; GO:0070487; GO:0070700; GO:0071456; GO:0071773; GO:0072040; GO:0072125; GO:0072133; GO:0072134; GO:0072136; GO:1900006; GO:1900106; GO:2000121 0 0 0 PF00019;PF00688; Q2HJM9 CHOYP_MEST.1.2 m.14365 sp MEST_BOVIN 46.44 323 159 5 9 323 15 331 7.39E-88 270 MEST_BOVIN reviewed Mesoderm-specific transcript homolog protein (EC 3.-.-.-) (Paternally-expressed gene 1 protein) MEST PEG1 Bos taurus (Bovine) 335 mesoderm development [GO:0007498]; regulation of lipid storage [GO:0010883] GO:0005783; GO:0005789; GO:0007498; GO:0010883; GO:0016021; GO:0016787 0 0 0 PF00561; Q4KMD3 CHOYP_U1SBP.1.2 m.36495 sp U1SBP_DANRE 61.677 167 64 0 6 172 3 169 7.39E-67 208 U1SBP_DANRE reviewed U11/U12 small nuclear ribonucleoprotein 35 kDa protein (U11/U12 snRNP 35 kDa protein) (U1 snRNP-binding protein homolog) snrnp35 u1snrnpbp zgc:112337 Danio rerio (Zebrafish) (Brachydanio rerio) 208 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000243; GO:0000398; GO:0003729; GO:0005689; GO:0017069; GO:0071011 0 0 0 PF00076; Q5U316 CHOYP_RAB35.1.1 m.8277 sp RAB35_RAT 77.561 205 41 2 1 204 1 201 7.39E-109 313 RAB35_RAT reviewed Ras-related protein Rab-35 Rab35 Rattus norvegicus (Rat) 201 antigen processing and presentation [GO:0019882]; cellular response to nerve growth factor stimulus [GO:1990090]; cytokinesis [GO:0000910]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; ER to Golgi vesicle-mediated transport [GO:0006888]; neuron projection development [GO:0031175]; plasma membrane to endosome transport [GO:0048227]; protein localization to endosome [GO:0036010]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0000910; GO:0003924; GO:0005525; GO:0005546; GO:0005739; GO:0005886; GO:0005905; GO:0006888; GO:0007264; GO:0010008; GO:0015031; GO:0016197; GO:0019003; GO:0019882; GO:0031175; GO:0031253; GO:0032456; GO:0036010; GO:0042470; GO:0045171; GO:0045334; GO:0048227; GO:0070062; GO:1990090 0 0 0 PF00071; Q6GNY1 CHOYP_LOC100370069.10.14 m.58550 sp MIB1_XENLA 40.506 79 41 3 226 304 8 80 7.39E-08 58.5 MIB1_XENLA reviewed E3 ubiquitin-protein ligase mib1 (EC 6.3.2.-) (Mind bomb homolog 1) mib1 Xenopus laevis (African clawed frog) 1011 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0005815; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q8IWZ3 CHOYP_LOC753709.19.44 m.36816 sp ANKH1_HUMAN 31.044 364 209 11 305 628 230 591 7.39E-34 142 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8JHV9 CHOYP_TIAP2.12.13 m.62840 sp BIR7A_XENLA 29.054 444 235 11 425 867 36 400 7.39E-50 184 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8K4G1 CHOYP_LOC100637228.1.1 m.6064 sp LTBP4_MOUSE 36.832 543 280 29 4 511 646 1160 7.39E-59 225 LTBP4_MOUSE reviewed Latent-transforming growth factor beta-binding protein 4 (LTBP-4) Ltbp4 Mus musculus (Mouse) 1666 hormone secretion [GO:0046879]; regulation of proteolysis [GO:0030162]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005509; GO:0005578; GO:0005615; GO:0007179; GO:0030162; GO:0031012; GO:0046879; GO:0050431; GO:0070062 0 0 0 PF07645;PF00683; Q8QFX1 CHOYP_RIMB1.4.5 m.63916 sp RIMB2_CHICK 51.563 64 28 1 557 617 1228 1291 7.39E-11 69.3 RIMB2_CHICK reviewed RIMS-binding protein 2 (RIM-BP2) RIMBP2 RBP2 Gallus gallus (Chicken) 1325 negative regulation of phosphatase activity [GO:0010923] GO:0005886; GO:0010923; GO:0030054; GO:0045202 0 0 0 PF07653;PF14604; Q99M80 CHOYP_PTPRG.3.3 m.65311 sp PTPRT_MOUSE 29.9 699 423 14 420 1059 762 1452 7.39E-88 313 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9CZJ2 CHOYP_LOC100372773.5.9 m.39567 sp HS12B_MOUSE 33.333 114 75 1 1 113 317 430 7.39E-15 73.2 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9UGM3 CHOYP_DMBT1.17.34 m.34458 sp DMBT1_HUMAN 43.2 625 262 14 4 540 530 1149 7.39E-125 407 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A4QNM5 CHOYP_BRAFLDRAFT_275293.1.1 m.16192 sp NUBP2_XENTR 64.202 257 92 0 12 268 9 265 7.40E-132 377 NUBP2_XENTR reviewed Cytosolic Fe-S cluster assembly factor nubp2 (Nucleotide-binding protein 2) (NBP 2) nubp2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 270 iron-sulfur cluster assembly [GO:0016226] GO:0005524; GO:0005737; GO:0016226; GO:0046872; GO:0051539 0 0 cd02037; 0 O43903 CHOYP_LOC100485604.1.1 m.45268 sp GAS2_HUMAN 39.384 292 149 5 38 302 22 312 7.40E-61 199 GAS2_HUMAN reviewed Growth arrest-specific protein 2 (GAS-2) GAS2 Homo sapiens (Human) 313 apoptotic process [GO:0006915]; cell cycle arrest [GO:0007050]; regulation of cell shape [GO:0008360] GO:0005829; GO:0005884; GO:0006915; GO:0007050; GO:0008360; GO:0016020 0 0 0 PF00307;PF02187; O75382 CHOYP_BRAFLDRAFT_69798.7.22 m.32839 sp TRIM3_HUMAN 24.324 259 163 11 299 539 486 729 7.40E-11 68.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O88279 CHOYP_BRAFLDRAFT_69264.4.6 m.38199 sp SLIT1_RAT 32.476 311 190 6 29 333 29 325 7.40E-37 145 SLIT1_RAT reviewed Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4) Slit1 Megf4 Rattus norvegicus (Rat) 1531 brain development [GO:0007420]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of synapse assembly [GO:0051964]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510] GO:0005509; GO:0005578; GO:0005615; GO:0007420; GO:0008201; GO:0021510; GO:0035385; GO:0043395; GO:0048495; GO:0048843; GO:0051964 0 0 0 PF00008;PF12661;PF02210;PF13855;PF01463;PF01462; P27080 CHOYP_CO6A5.1.6 m.5840 sp ADT_CHLRE 65.902 305 102 2 1 303 1 305 7.40E-141 402 ADT_CHLRE reviewed "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" ABT Chlamydomonas reinhardtii (Chlamydomonas smithii) 308 transmembrane transport [GO:0055085] GO:0005215; GO:0005743; GO:0016021; GO:0055085 0 0 0 PF00153; P27080 CHOYP_LOC100633390.5.5 m.64527 sp ADT_CHLRE 65.902 305 102 2 1 303 1 305 7.40E-141 402 ADT_CHLRE reviewed "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" ABT Chlamydomonas reinhardtii (Chlamydomonas smithii) 308 transmembrane transport [GO:0055085] GO:0005215; GO:0005743; GO:0016021; GO:0055085 0 0 0 PF00153; P27080 CHOYP_SRC8.1.1 m.40903 sp ADT_CHLRE 65.902 305 102 2 1 303 1 305 7.40E-141 402 ADT_CHLRE reviewed "ADP,ATP carrier protein (ADP/ATP translocase) (Adenine nucleotide translocator) (ANT)" ABT Chlamydomonas reinhardtii (Chlamydomonas smithii) 308 transmembrane transport [GO:0055085] GO:0005215; GO:0005743; GO:0016021; GO:0055085 0 0 0 PF00153; Q5U2Z0 CHOYP_ZN367.1.1 m.25590 sp ZN367_RAT 71.93 114 32 0 220 333 120 233 7.40E-52 178 ZN367_RAT reviewed Zinc finger protein 367 Znf367 Zfp367 Rattus norvegicus (Rat) 340 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005654; GO:0006351; GO:0006357; GO:0046872 0 0 0 PF13912; Q6DFV8 CHOYP_LOC101068378.2.3 m.20090 sp VWDE_MOUSE 22.985 918 561 42 41 860 50 919 7.40E-28 125 VWDE_MOUSE reviewed von Willebrand factor D and EGF domain-containing protein Vwde Gm467 Mus musculus (Mouse) 926 0 GO:0005576 0 0 0 PF00094; Q800K6 CHOYP_TOPB1.1.1 m.64913 sp TOB1A_XENLA 41.923 749 403 14 4 740 7 735 7.40E-173 565 TOB1A_XENLA reviewed DNA topoisomerase 2-binding protein 1-A (Cut5 protein) (DNA topoisomerase II-binding protein 1-A) (TopBP1-A) (XtopBP) topbp1-A cut5 Xenopus laevis (African clawed frog) 1513 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; DNA replication checkpoint [GO:0000076]; DNA replication initiation [GO:0006270]; DNA replication preinitiation complex assembly [GO:0071163]; GINS complex assembly [GO:0071165]; positive regulation of chromatin binding [GO:0035563]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein kinase activity [GO:0045860]; protein localization to chromatin [GO:0071168]; regulation of DNA-dependent DNA replication initiation [GO:0030174] GO:0000076; GO:0000785; GO:0000922; GO:0003677; GO:0003682; GO:0005634; GO:0005737; GO:0005815; GO:0006270; GO:0006281; GO:0006974; GO:0019900; GO:0030174; GO:0033138; GO:0035563; GO:0045860; GO:0071163; GO:0071165; GO:0071168 0 0 0 PF00533;PF12738; Q80T91 CHOYP_contig_030621 m.34884 sp MEG11_MOUSE 40.411 146 79 6 75 219 393 531 7.40E-19 87.8 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q96I24 CHOYP_BRAFLDRAFT_124476.1.4 m.1812 sp FUBP3_HUMAN 38.754 658 260 15 48 666 19 572 7.40E-114 358 FUBP3_HUMAN reviewed Far upstream element-binding protein 3 (FUSE-binding protein 3) FUBP3 FBP3 Homo sapiens (Human) 572 "positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0001077; GO:0005634; GO:0005737; GO:0006351; GO:0010628; GO:0016020; GO:0044822; GO:0045893; GO:0045944 0 0 0 PF00013; Q96MD2 CHOYP_BRAFLDRAFT_114977.1.2 m.14437 sp CL066_HUMAN 41.441 444 241 8 14 451 14 444 7.40E-108 329 CL066_HUMAN reviewed UPF0536 protein C12orf66 C12orf66 Homo sapiens (Human) 445 0 GO:0015630; GO:0045171 0 0 0 PF09404; Q9ESN6 CHOYP_BRAFLDRAFT_63526.2.2 m.32607 sp TRIM2_MOUSE 25.417 240 147 9 314 536 510 734 7.40E-08 58.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H4E5 CHOYP_CDC42.7.11 m.36272 sp RHOJ_HUMAN 39.247 186 102 2 5 180 16 200 7.40E-47 155 RHOJ_HUMAN reviewed Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein) RHOJ ARHJ RASL7B RHOI TCL Homo sapiens (Human) 214 actin cytoskeleton organization [GO:0030036]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; Rho protein signal transduction [GO:0007266] GO:0003924; GO:0005525; GO:0005829; GO:0005886; GO:0007266; GO:0008360; GO:0030036; GO:0051056; GO:0061299; GO:0070062 0 0 0 PF00071; Q9NQX3 CHOYP_GEPH.1.2 m.49093 sp GEPH_HUMAN 57.968 433 179 3 260 689 304 736 7.40E-167 499 GEPH_HUMAN reviewed Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] GPHN GPH KIAA1385 Homo sapiens (Human) 736 gamma-aminobutyric acid receptor clustering [GO:0097112]; glycine receptor clustering [GO:0072579]; molybdenum incorporation into molybdenum-molybdopterin complex [GO:0018315]; molybdopterin cofactor biosynthetic process [GO:0032324]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777] GO:0005524; GO:0005737; GO:0005856; GO:0005886; GO:0006777; GO:0018315; GO:0030054; GO:0030425; GO:0032324; GO:0045211; GO:0046872; GO:0061598; GO:0061599; GO:0072579; GO:0097112 "PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000269|PubMed:11095995, ECO:0000269|PubMed:22040219, ECO:0000269|PubMed:26613940}." 0 0 PF00994;PF03454;PF03453; A7MCB7 CHOYP_TMA16.1.1 m.28162 sp TMA16_DANRE 45.455 187 100 2 1 187 1 185 7.41E-48 157 TMA16_DANRE reviewed Translation machinery-associated protein 16 tma16 zgc:110664 Danio rerio (Zebrafish) (Brachydanio rerio) 194 0 0 0 0 0 PF11176; E1BLP6 CHOYP_ARI5B.1.1 m.11230 sp ARI5B_BOVIN 39.771 523 236 15 1 489 1 478 7.41E-98 335 ARI5B_BOVIN reviewed AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) ARID5B Bos taurus (Bovine) 1173 "adipose tissue development [GO:0060612]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006357; GO:0044212; GO:0051091; GO:0060612 0 0 0 PF01388; P16444 CHOYP_LOC592585.1.1 m.51309 sp DPEP1_HUMAN 50.423 355 155 7 76 428 23 358 7.41E-117 351 DPEP1_HUMAN reviewed Dipeptidase 1 (EC 3.4.13.19) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP) DPEP1 MDP RDP Homo sapiens (Human) 411 antibiotic metabolic process [GO:0016999]; cellular lactam catabolic process [GO:0072340]; cellular response to calcium ion [GO:0071277]; cellular response to drug [GO:0035690]; cellular response to nitric oxide [GO:0071732]; glutathione metabolic process [GO:0006749]; homocysteine metabolic process [GO:0050667]; leukotriene metabolic process [GO:0006691]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell migration [GO:0030336]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; xenobiotic metabolic process [GO:0006805] GO:0005615; GO:0005886; GO:0006691; GO:0006749; GO:0006805; GO:0008235; GO:0008239; GO:0008270; GO:0016324; GO:0016805; GO:0016999; GO:0030336; GO:0031225; GO:0031528; GO:0034235; GO:0035690; GO:0043027; GO:0043066; GO:0043154; GO:0045177; GO:0050667; GO:0070062; GO:0070573; GO:0071277; GO:0071732; GO:0072340; GO:0072341 0 0 0 PF01244; P49900 CHOYP_ARG1.1.1 m.18786 sp ARGI_LITCT 55.556 279 122 2 3 280 44 321 7.41E-105 313 ARGI_LITCT reviewed "Arginase, hepatic (EC 3.5.3.1)" 0 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 323 arginine metabolic process [GO:0006525]; urea cycle [GO:0000050] GO:0000050; GO:0004053; GO:0006525; GO:0046872 PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000250|UniProtKB:P05089}. 0 0 PF00491; P79781 CHOYP_RL9.1.6 m.5940 sp RS27A_CHICK 97.458 118 3 0 1 118 1 118 7.41E-79 232 RS27A_CHICK reviewed Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a] RPS27A UBA80 Gallus gallus (Chicken) 156 DNA repair [GO:0006281]; translation [GO:0006412]; translesion synthesis [GO:0019985] GO:0003735; GO:0005615; GO:0005654; GO:0005730; GO:0006281; GO:0006412; GO:0016020; GO:0019985; GO:0022627; GO:0043209; GO:0044822; GO:0046872; GO:0070062 0 0 0 PF01599;PF00240; P83515 CHOYP_LOC100378295.4.4 m.36597 sp SCAL2_STRCA 30.579 121 66 6 37 150 30 139 7.41E-06 48.9 SCAL2_STRCA reviewed Struthiocalcin-2 (SCA-2) 0 Struthio camelus (Common ostrich) 142 0 GO:0005578; GO:0030246 0 0 0 PF00059; Q0IH24 CHOYP_SMP_060160.1.1 m.22650 sp SPEF1_XENLA 35.714 224 104 5 6 223 37 226 7.41E-26 103 SPEF1_XENLA reviewed Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) 229 0 GO:0005737; GO:0005930 0 0 0 PF06294; Q32Q07 CHOYP_ISCW_ISCW001410.1.1 m.1226 sp LRRN1_RAT 28.19 674 438 18 46 697 32 681 7.41E-63 226 LRRN1_RAT reviewed Leucine-rich repeat neuronal protein 1 (Neuronal leucine-rich repeat protein 1) (NLRR-1) Lrrn1 Rattus norvegicus (Rat) 716 positive regulation of synapse assembly [GO:0051965] GO:0016021; GO:0051965 0 0 0 PF07679;PF13855;PF01463; Q54KA7 CHOYP_AFUA_1G01020.17.50 m.23839 sp SECG_DICDI 33.861 505 313 3 13 515 70 555 7.41E-72 250 SECG_DICDI reviewed "Ankyrin repeat, PH and SEC7 domain containing protein secG" secG DDB_G0287459 Dictyostelium discoideum (Slime mold) 986 actin cytoskeleton organization [GO:0030036]; cell-substrate adhesion [GO:0031589]; chemotaxis [GO:0006935]; chemotaxis to cAMP [GO:0043327]; culmination involved in sorocarp development [GO:0031154]; protein targeting to plasma membrane [GO:0072661]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0005764; GO:0005829; GO:0006935; GO:0008093; GO:0030036; GO:0030507; GO:0031154; GO:0031589; GO:0032012; GO:0043327; GO:0072661 0 0 0 PF00023;PF12796;PF00169;PF01369; Q6AX59 CHOYP_LOC100377220.1.1 m.36306 sp ABHD8_XENLA 44.398 241 130 2 231 467 167 407 7.41E-70 233 ABHD8_XENLA reviewed Protein ABHD8 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 8) (Abhydrolase domain-containing protein 8) abhd8 Xenopus laevis (African clawed frog) 424 0 GO:0016787 0 0 0 PF00561; Q8INF0 CHOYP_BRAFLDRAFT_63939.1.1 m.29288 sp GCY8E_DROME 41.876 437 247 4 3 439 167 596 7.41E-114 363 GCY8E_DROME reviewed Soluble guanylate cyclase 88E (EC 4.6.1.2) Gyc88E CG4154 Drosophila melanogaster (Fruit fly) 947 cGMP biosynthetic process [GO:0006182]; intracellular signal transduction [GO:0035556]; response to hypoxia [GO:0001666]; response to reactive oxygen species [GO:0000302]; signal transduction [GO:0007165] GO:0000302; GO:0001666; GO:0004383; GO:0005525; GO:0005886; GO:0006182; GO:0007165; GO:0008074; GO:0019825; GO:0019826; GO:0020037; GO:0035556; GO:0042803; GO:0046872; GO:0046982; GO:0070025; GO:0070026 0 0 0 PF00211;PF07700;PF07701; Q8N895 CHOYP_ZNF366.1.1 m.1515 sp ZN366_HUMAN 54.755 347 151 4 502 843 215 560 7.41E-126 403 ZN366_HUMAN reviewed Zinc finger protein 366 ZNF366 Homo sapiens (Human) 744 "negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; response to estrogen [GO:0043627]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0003714; GO:0005634; GO:0006351; GO:0030331; GO:0033147; GO:0043627; GO:0046872 0 0 0 PF00096;PF13912; Q9R1R2 CHOYP_TRIM3.44.58 m.47066 sp TRIM3_MOUSE 25.468 267 183 8 20 276 482 742 7.41E-13 72 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9WVB4 CHOYP_LOC100486910.1.1 m.6999 sp SLIT3_MOUSE 39.326 89 50 1 1 85 785 873 7.41E-11 65.1 SLIT3_MOUSE reviewed Slit homolog 3 protein (Slit-3) (Slit3) Slit3 Mus musculus (Mouse) 1523 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cellular response to hormone stimulus [GO:0032870]; negative chemotaxis [GO:0050919]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of gene expression [GO:0010629]; organ morphogenesis [GO:0009887]; regulation of axonogenesis [GO:0050770]; response to cortisol [GO:0051414]; Roundabout signaling pathway [GO:0035385] GO:0005102; GO:0005509; GO:0005578; GO:0005615; GO:0007411; GO:0008201; GO:0008285; GO:0009887; GO:0010629; GO:0030308; GO:0032870; GO:0035385; GO:0048495; GO:0048846; GO:0050770; GO:0050919; GO:0051414; GO:0061364; GO:0070100 0 0 0 PF00008;PF12661;PF02210;PF13855;PF01463;PF01462; I3LM39 CHOYP_LOC100567354.1.2 m.4232 sp CGAS_PIG 25.726 482 283 19 88 534 45 486 7.42E-21 99.4 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O15016 CHOYP_LOC100368020.23.29 m.39025 sp TRI66_HUMAN 23.858 197 120 6 2 174 16 206 7.42E-08 55.5 TRI66_HUMAN reviewed Tripartite motif-containing protein 66 TRIM66 C11orf29 KIAA0298 Homo sapiens (Human) 1216 0 GO:0005654; GO:0008270; GO:0016235 0 0 0 PF00439;PF00628;PF00643; O43301 CHOYP_HS12B.12.14 m.61908 sp HS12A_HUMAN 33.904 643 363 15 30 617 38 673 7.42E-115 360 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P23416 CHOYP_LOC100533289.1.6 m.1514 sp GLRA2_HUMAN 42.651 415 193 9 26 405 42 446 7.42E-112 338 GLRA2_HUMAN reviewed Glycine receptor subunit alpha-2 GLRA2 Homo sapiens (Human) 452 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glycinergic [GO:0060012]" GO:0005886; GO:0005887; GO:0007218; GO:0007416; GO:0016594; GO:0016934; GO:0021510; GO:0022852; GO:0030054; GO:0034220; GO:0034707; GO:0042995; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; P42297 CHOYP_LOC100180023.1.7 m.11060 sp YXIE_BACSU 26.974 152 94 5 6 148 5 148 7.42E-09 54.3 YXIE_BACSU reviewed Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) 148 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P42297 CHOYP_LOC100180023.2.7 m.28766 sp YXIE_BACSU 26.974 152 94 5 6 148 5 148 7.42E-09 54.3 YXIE_BACSU reviewed Universal stress protein YxiE (USP YxiE) yxiE BSU39250 N17E Bacillus subtilis (strain 168) 148 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P48445 CHOYP_BPL1.1.1 m.15002 sp BPL1_YEAST 26.49 302 154 10 9 306 3 240 7.42E-22 99.4 BPL1_YEAST reviewed Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] BPL1 ACC2 YDL141W D2140 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 690 protein biotinylation [GO:0009305] GO:0004077; GO:0004078; GO:0004079; GO:0004080; GO:0005524; GO:0005737; GO:0009305; GO:0071734 0 0 0 PF02237;PF03099;PF09825; P70031 CHOYP_contig_020484 m.23677 sp CCKAR_XENLA 21.372 379 238 14 20 381 73 408 7.42E-09 60.8 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q03484 CHOYP_C_EBP.1.1 m.5514 sp CEBPD_RAT 42.697 89 44 3 161 244 165 251 7.42E-12 67 CEBPD_RAT reviewed CCAAT/enhancer-binding protein delta (C/EBP delta) (Transcription factor CELF) Cebpd Celf Rattus norvegicus (Rat) 268 positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000978; GO:0001077; GO:0005634; GO:0043565; GO:0045944 0 0 0 PF07716; Q08AY9 CHOYP_DGRI_GH16740.1.1 m.14504 sp FA89A_XENLA 34.677 124 59 3 4 127 15 116 7.42E-11 61.2 FA89A_XENLA reviewed Protein FAM89A fam89a Xenopus laevis (African clawed frog) 166 0 0 0 0 0 0 Q5REG4 CHOYP_DTX3.2.3 m.55266 sp DTX3_PONAB 51.295 193 90 4 733 922 155 346 7.42E-60 211 DTX3_PONAB reviewed Probable E3 ubiquitin-protein ligase DTX3 (EC 6.3.2.-) (Protein deltex-3) (Deltex3) DTX3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 347 Notch signaling pathway [GO:0007219]; protein ubiquitination [GO:0016567] GO:0005737; GO:0007219; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q6NXB2 CHOYP_PDZ11.2.2 m.56108 sp PDZ11_DANRE 52 125 59 1 14 138 17 140 7.42E-45 146 PDZ11_DANRE reviewed PDZ domain-containing protein 11 pdzd11 pdzk11 zgc:77536 Danio rerio (Zebrafish) (Brachydanio rerio) 142 exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361] GO:0005829; GO:0005911; GO:0006887; GO:0007269; GO:0008022; GO:0016323; GO:0045199; GO:0045202; GO:0098793; GO:1903361 0 0 0 PF00595; Q8IYB1 CHOYP_NEMVEDRAFT_V1G218264.3.14 m.13399 sp M21D2_HUMAN 25.904 166 103 5 36 194 233 385 7.42E-08 56.2 M21D2_HUMAN reviewed Protein MB21D2 (Mab-21 domain-containing protein 2) MB21D2 C3orf59 Homo sapiens (Human) 491 0 GO:0005913; GO:0032403; GO:0098641 0 0 0 PF03281; Q8TF42 CHOYP_UBS3B.1.1 m.43636 sp UBS3B_HUMAN 39.61 616 354 8 9 611 25 635 7.42E-149 447 UBS3B_HUMAN reviewed Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2) UBASH3B KIAA1959 STS1 Homo sapiens (Human) 649 negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of signal transduction [GO:0009968]; regulation of release of sequestered calcium ion into cytosol [GO:0051279] GO:0004725; GO:0005634; GO:0005737; GO:0006469; GO:0009968; GO:0045671; GO:0045779; GO:0051279; GO:0090331 0 0 cd07067; PF00300;PF14604;PF00627; Q8WWK9 CHOYP_CKAP2.1.1 m.18981 sp CKAP2_HUMAN 26.667 255 120 9 383 576 421 669 7.42E-12 72 CKAP2_HUMAN reviewed Cytoskeleton-associated protein 2 (CTCL tumor antigen se20-10) (Tumor- and microtubule-associated protein) CKAP2 LB1 TMAP Homo sapiens (Human) 683 apoptotic process [GO:0006915]; mitotic cytokinesis [GO:0000281]; negative regulation of microtubule depolymerization [GO:0007026]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0000281; GO:0000922; GO:0005737; GO:0005813; GO:0005881; GO:0006915; GO:0007026; GO:0015630; GO:0045944 0 0 0 PF15297; Q95JY7 CHOYP_LOC581901.1.1 m.27291 sp CF163_MACFA 30.556 288 181 9 25 302 30 308 7.42E-14 74.3 CF163_MACFA reviewed Uncharacterized protein C6orf163 homolog QtsA-12155 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 329 0 0 0 0 0 0 Q9CSU0 CHOYP_RPR1B.1.1 m.25629 sp RPR1B_MOUSE 51.36 331 141 3 1 318 1 324 7.42E-107 317 RPR1B_MOUSE reviewed Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) Rprd1b Crept Mus musculus (Mouse) 326 "dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle process [GO:0010564]; transcription, DNA-templated [GO:0006351]" GO:0000993; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006351; GO:0008284; GO:0010564; GO:0016591; GO:0045944; GO:0070940 0 0 0 PF16566;PF04818; Q9IA76 CHOYP_LOC100180716.2.2 m.57847 sp RL31_PAROL 79.121 91 19 0 14 104 25 115 7.42E-50 157 RL31_PAROL reviewed 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) 124 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00463; PF01198; Q9VEU1 CHOYP_FAT1.1.4 m.6024 sp CAD89_DROME 30.348 402 242 13 193 568 237 626 7.42E-39 156 CAD89_DROME reviewed Cadherin-89D Cad89D CG14900 Drosophila melanogaster (Fruit fly) 2240 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005887; GO:0007156; GO:0016339; GO:0044331 0 0 0 PF00028; Q9Y493 CHOYP_NEMVEDRAFT_V1G238277.1.1 m.17772 sp ZAN_HUMAN 23.577 123 73 1 170 271 576 698 7.42E-08 57 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; O75179 CHOYP_LOC754047.3.3 m.58660 sp ANR17_HUMAN 31.273 550 309 17 743 1275 222 719 7.43E-51 202 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_TRIM3.33.58 m.36273 sp TRIM3_HUMAN 25.296 253 143 9 202 442 514 732 7.43E-12 71.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06857 CHOYP_contig_011865 m.13635 sp LIPR1_CANLF 30.189 106 65 2 61 157 46 151 7.43E-07 50.8 LIPR1_CANLF reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Canis lupus familiaris (Dog) (Canis familiaris) 467 lipid catabolic process [GO:0016042] GO:0005509; GO:0005576; GO:0016042; GO:0052689 0 0 0 PF00151;PF01477; P19351 CHOYP_SMP_179810.1.3 m.246 sp TNNT_DROME 41.667 180 101 3 34 211 52 229 7.43E-19 87 TNNT_DROME reviewed "Troponin T, skeletal muscle (Protein intended thorax) (Protein upheld)" up int CG7107 Drosophila melanogaster (Fruit fly) 397 cellular calcium ion homeostasis [GO:0006874]; mesoderm development [GO:0007498]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; muscle organ morphogenesis [GO:0048644]; myofibril assembly [GO:0030239]; regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214]; skeletal muscle thin filament assembly [GO:0030240] GO:0005509; GO:0005861; GO:0005865; GO:0006874; GO:0006937; GO:0007005; GO:0007498; GO:0030239; GO:0030240; GO:0045214; GO:0046716; GO:0048644 0 0 0 PF00992; P29590 CHOYP_LOC100377759.8.15 m.37473 sp PML_HUMAN 23.75 240 157 4 64 301 606 821 7.43E-13 72.8 PML_HUMAN reviewed Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) 882 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006915; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0016925; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045892; GO:0045930; GO:0046982; GO:0048146; GO:0048384; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060333; GO:0060444; GO:0070059; GO:0071353; GO:0090398; GO:0097191; GO:1901796; GO:1902187; GO:1904816; GO:2000059; GO:2000779; GO:2001238 0 0 0 PF12126;PF00643; Q3TLR7 CHOYP_DTL.1.1 m.66971 sp DTL_MOUSE 46.667 195 99 2 25 214 50 244 7.43E-51 178 DTL_MOUSE reviewed Denticleless protein homolog (Lethal(2) denticleless protein homolog) (Meth A retinoic acid-regulated nuclear matrix-associated protein) (Meth A RAMP) (Retinoic acid-regulated nuclear matrix-associated protein) Dtl Cdt2 L2dtl Ramp Mus musculus (Mouse) 729 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; G2 DNA damage checkpoint [GO:0031572]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006260; GO:0006511; GO:0006513; GO:0006974; GO:0009411; GO:0019985; GO:0031464; GO:0031465; GO:0031572; GO:0031965; GO:0043231; GO:0051726 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q502M6 CHOYP_TVAG_003440.1.1 m.32985 sp ANR29_DANRE 35.714 224 143 1 7 230 43 265 7.43E-41 144 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5R9Y3 CHOYP_LOC591612.1.2 m.25525 sp ABT1_PONAB 36.098 205 102 3 28 219 45 233 7.43E-45 154 ABT1_PONAB reviewed Activator of basal transcription 1 ABT1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 272 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0003723; GO:0005730; GO:0006351; GO:0006355 0 0 0 0 Q5T089 CHOYP_BRAFLDRAFT_124536.1.2 m.10834 sp MORN1_HUMAN 32.839 539 274 12 21 548 25 486 7.43E-87 281 MORN1_HUMAN reviewed MORN repeat-containing protein 1 MORN1 Homo sapiens (Human) 497 0 0 0 0 0 PF02493; Q9D110 CHOYP_LOC100645802.1.1 m.63091 sp MTHFS_MOUSE 38.974 195 115 3 54 245 4 197 7.43E-39 137 MTHFS_MOUSE reviewed "5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)" Mthfs Mus musculus (Mouse) 203 folic acid-containing compound biosynthetic process [GO:0009396]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653] GO:0005524; GO:0005542; GO:0005737; GO:0005739; GO:0005759; GO:0009396; GO:0030272; GO:0035999; GO:0046653; GO:0046872 0 0 0 PF01812; Q9ESN6 CHOYP_TRIM3.30.58 m.32938 sp TRIM2_MOUSE 27.374 179 115 6 135 309 536 703 7.43E-11 66.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H8G2 CHOYP_CAAP1.1.1 m.28222 sp CAAP1_HUMAN 38.356 73 45 0 52 124 127 199 7.43E-10 62 CAAP1_HUMAN reviewed Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) CAAP1 C9orf82 CAAP Homo sapiens (Human) 361 apoptotic process [GO:0006915] GO:0006915 0 0 0 0 A3DH97 CHOYP_BRAFLDRAFT_81364.1.3 m.4568 sp RSGI6_CLOTH 31.593 364 235 8 195 554 379 732 7.44E-49 184 RSGI6_CLOTH reviewed "Anti-sigma-I factor RsgI6 (Endo-1,4-beta-xylanase) (EC 3.2.1.8)" rsgI6 Cthe_2119 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 760 xylan catabolic process [GO:0045493] GO:0005886; GO:0016021; GO:0031176; GO:0045493 PATHWAY: Glycan degradation; xylan degradation. {ECO:0000255|PROSITE-ProRule:PRU01096}. 0 0 PF00331;PF12791; P17126 CHOYP_ACT.11.27 m.37944 sp ACT_HYDVU 97.861 187 4 0 1 187 10 196 7.44E-136 389 ACT_HYDVU reviewed "Actin, non-muscle 6.2" 0 Hydra vulgaris (Hydra) (Hydra attenuata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q01528 CHOYP_HAAF.5.13 m.16553 sp HAAF_LIMPO 38.596 171 98 4 16 183 2 168 7.44E-37 128 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q4R544 CHOYP_ANK1.2.8 m.14789 sp ASB8_MACFA 34.426 122 78 2 247 368 57 176 7.44E-11 66.2 ASB8_MACFA reviewed Ankyrin repeat and SOCS box protein 8 (ASB-8) ASB8 QccE-19709 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 288 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005737; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q5T5U3 CHOYP_BRAFLDRAFT_125209.1.1 m.43149 sp RHG21_HUMAN 38.809 554 262 17 821 1323 920 1447 7.44E-96 349 RHG21_HUMAN reviewed Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21) ARHGAP21 ARHGAP10 KIAA1424 Homo sapiens (Human) 1957 establishment of Golgi localization [GO:0051683]; Golgi organization [GO:0007030]; maintenance of Golgi location [GO:0051684]; organelle transport along microtubule [GO:0072384]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165] GO:0000139; GO:0005096; GO:0005794; GO:0005856; GO:0007030; GO:0007165; GO:0030054; GO:0030659; GO:0043547; GO:0051683; GO:0051684; GO:0072384 0 0 0 PF00595;PF00620; Q5ZML3 CHOYP_ISCW_ISCW014398.1.3 m.15838 sp SRSF1_CHICK 71.078 204 51 2 4 206 13 209 7.44E-84 253 SRSF1_CHICK reviewed "Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1)" SRSF1 SFRS1 RCJMB04_1l5 Gallus gallus (Chicken) 257 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005737; GO:0006397; GO:0008380; GO:0016607 0 0 0 PF00076; Q6ZMT9 CHOYP_BRAFLDRAFT_123768.1.1 m.7223 sp DTHD1_HUMAN 25.888 591 375 16 907 1468 209 765 7.44E-39 160 DTHD1_HUMAN reviewed Death domain-containing protein 1 DTHD1 Homo sapiens (Human) 781 signal transduction [GO:0007165] GO:0005634; GO:0007165 0 0 0 PF00531; Q7ZUN8 CHOYP_BRAFLDRAFT_126152.2.2 m.42694 sp YKT6_DANRE 61.616 198 76 0 1 198 1 198 7.44E-81 241 YKT6_DANRE reviewed Synaptobrevin homolog YKT6 (EC 2.3.1.-) ykt6 zgc:55536 Danio rerio (Zebrafish) (Brachydanio rerio) 198 exocytosis [GO:0006887]; protein transport [GO:0015031]; vesicle fusion [GO:0006906] GO:0000139; GO:0000149; GO:0005484; GO:0005829; GO:0006887; GO:0006906; GO:0015031; GO:0016021; GO:0016740; GO:0030659; GO:0031201 0 0 0 PF13774;PF00957; Q803U7 CHOYP_EXO1.1.2 m.16960 sp EXO1_DANRE 66.5 200 67 0 1 200 1 200 7.44E-92 288 EXO1_DANRE reviewed Exonuclease 1 (EC 3.1.-.-) (Exonuclease I) exo1 zgc:55521 Danio rerio (Zebrafish) (Brachydanio rerio) 806 DNA recombination [GO:0006310]; mismatch repair [GO:0006298] GO:0003677; GO:0005634; GO:0006298; GO:0006310; GO:0045145; GO:0046872; GO:0048256 0 0 0 PF00867;PF00752; Q8NDA2 CHOYP_AGAP_AGAP010186.1.1 m.62503 sp HMCN2_HUMAN 22.804 592 350 23 165 683 2575 3132 7.44E-20 100 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8VDP6 CHOYP_CDIPT.1.1 m.56714 sp CDIPT_MOUSE 53.333 210 98 0 3 212 4 213 7.44E-84 250 CDIPT_MOUSE reviewed CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) Cdipt Pis1 Mus musculus (Mouse) 213 CDP-diacylglycerol metabolic process [GO:0046341]; phosphatidylinositol biosynthetic process [GO:0006661] GO:0000139; GO:0003881; GO:0005789; GO:0005794; GO:0005886; GO:0006661; GO:0016020; GO:0016021; GO:0019992; GO:0030145; GO:0030246; GO:0043178; GO:0046341 0 0 0 PF01066; Q9CQ29 CHOYP_LOC100635838.1.1 m.10456 sp RN151_MOUSE 37.079 89 45 4 29 114 3 83 7.44E-07 53.5 RN151_MOUSE reviewed RING finger protein 151 Rnf151 Mus musculus (Mouse) 239 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0004842; GO:0005634; GO:0005737; GO:0007283; GO:0008270; GO:0030154 0 0 0 PF02176; Q9CZ15 CHOYP_BRAFLDRAFT_120278.1.2 m.15014 sp PSF1_MOUSE 61.026 195 75 1 1 194 1 195 7.44E-88 259 PSF1_MOUSE reviewed DNA replication complex GINS protein PSF1 (GINS complex subunit 1) Gins1 Psf1 Mus musculus (Mouse) 196 DNA replication [GO:0006260]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; inner cell mass cell proliferation [GO:0001833] GO:0000811; GO:0001833; GO:0005634; GO:0005737; GO:0006260; GO:0043138; GO:1902983 0 0 cd11710; 0 Q9R1R2 CHOYP_BRAFLDRAFT_87327.1.13 m.3250 sp TRIM3_MOUSE 26.016 123 86 3 70 188 622 743 7.44E-07 52.8 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9VCA2 CHOYP_ORCT.3.6 m.40082 sp ORCT_DROME 36.94 536 304 10 1 520 1 518 7.44E-95 302 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; A2AVA0 CHOYP_ISCW_ISCW022021.1.1 m.53168 sp SVEP1_MOUSE 27.356 329 209 12 16 321 515 836 7.45E-16 84 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; P18433 CHOYP_LOC100208023.7.8 m.46804 sp PTPRA_HUMAN 29.445 703 446 17 683 1364 107 780 7.45E-83 293 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P20280 CHOYP_RL21.4.4 m.63044 sp RL21_RAT 68.182 88 28 0 34 121 17 104 7.45E-40 133 RL21_RAT reviewed 60S ribosomal protein L21 Rpl21 Rattus norvegicus (Rat) 160 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625 0 0 0 PF01157; P22856 CHOYP_GSPATT00006808001.1.1 m.56430 sp VL96_IRV1 26.582 158 99 4 122 270 595 744 7.45E-11 68.6 VL96_IRV1 reviewed Putative ubiquitin thioesterase L96 (EC 3.4.19.12) L96 Tipula iridescent virus (TIV) (Insect iridescent virus type 1) 867 "DNA-templated transcription, termination [GO:0006353]; viral release from host cell [GO:0019076]" GO:0003677; GO:0006353; GO:0019076; GO:0036459 0 0 0 PF02338; Q1T7B9 CHOYP_BRAFLDRAFT_117555.1.1 m.7490 sp CENPM_CHICK 35.227 176 113 1 4 178 2 177 7.45E-32 115 CENPM_CHICK reviewed Centromere protein M (CENP-M) CENPM Gallus gallus (Chicken) 177 0 GO:0000775; GO:0005634 0 0 0 PF11111; Q3KPT0 CHOYP_LOC100375592.1.6 m.11899 sp CC169_XENLA 44.828 145 78 2 8 152 17 159 7.45E-32 119 CC169_XENLA reviewed Coiled-coil domain-containing protein 169 ccdc169 Xenopus laevis (African clawed frog) 214 0 0 0 0 0 PF15372; Q5ZJP5 CHOYP_LOC577931.3.3 m.35021 sp FND3A_CHICK 24.058 345 213 13 244 562 565 886 7.45E-08 60.8 FND3A_CHICK reviewed Fibronectin type-III domain-containing protein 3a FNDC3A FNDC3 RCJMB04_16k12 Gallus gallus (Chicken) 1198 0 GO:0000139; GO:0016021 0 0 0 PF00041; Q80ZA4 CHOYP_PKHD1L1.4.5 m.24363 sp PKHL1_MOUSE 37.265 746 439 11 14 739 2956 3692 7.45E-156 504 PKHL1_MOUSE reviewed Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) Pkhd1l1 Mus musculus (Mouse) 4249 0 GO:0005929; GO:0016021 0 0 0 PF10162;PF07691;PF01833; Q8BH70 CHOYP_PHUM_PHUM257210.1.3 m.46177 sp FBXL4_MOUSE 28.962 183 98 5 17 167 47 229 7.45E-15 78.2 FBXL4_MOUSE reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) Fbxl4 Mus musculus (Mouse) 621 0 GO:0004842; GO:0005654; GO:0005758 0 0 0 PF00646; Q8WQI5 CHOYP_RS8.4.14 m.31220 sp RS8_SPOFR 67 100 31 1 2 101 104 201 7.45E-42 139 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; Q9EPS3 CHOYP_LOC100370244.2.4 m.49849 sp GLCE_MOUSE 43.36 625 308 14 5 596 7 618 7.45E-173 507 GLCE_MOUSE reviewed D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin sulfate C5-epimerase) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) Glce Mus musculus (Mouse) 618 glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] GO:0000139; GO:0005794; GO:0006024; GO:0015012; GO:0016021; GO:0016857; GO:0030210; GO:0047464; GO:0050379 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis. 0 0 PF06662; Q9NVE4 CHOYP_LOC100376463.1.1 m.22962 sp CCD87_HUMAN 24.077 623 358 15 171 764 83 619 7.45E-37 154 CCD87_HUMAN reviewed Coiled-coil domain-containing protein 87 CCDC87 Homo sapiens (Human) 849 0 0 0 0 0 0 Q9UKK3 CHOYP_LOC100373327.5.13 m.30505 sp PARP4_HUMAN 44.601 426 227 5 3 421 788 1211 7.45E-102 363 PARP4_HUMAN reviewed Poly [ADP-ribose] polymerase 4 (PARP-4) (EC 2.4.2.30) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Vault poly(ADP-ribose) polymerase) (VPARP) PARP4 ADPRTL1 KIAA0177 PARPL Homo sapiens (Human) 1724 cell death [GO:0008219]; cellular protein modification process [GO:0006464]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; inflammatory response [GO:0006954]; protein ADP-ribosylation [GO:0006471]; response to drug [GO:0042493]; transport [GO:0006810] GO:0003677; GO:0003950; GO:0005634; GO:0005737; GO:0005876; GO:0006281; GO:0006464; GO:0006471; GO:0006810; GO:0006954; GO:0006974; GO:0008219; GO:0016020; GO:0019899; GO:0030529; GO:0042493; GO:0070062 0 0 0 PF00533;PF00644;PF08487;PF00092; A4IF63 CHOYP_BRAFLDRAFT_117187.4.4 m.64550 sp TRIM2_BOVIN 23.984 246 174 8 7 244 502 742 7.46E-08 56.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6NN14 CHOYP_ZNF99.1.3 m.6996 sp ZN729_HUMAN 25.403 807 456 24 19 736 457 1206 7.46E-41 165 ZN729_HUMAN reviewed Zinc finger protein 729 ZNF729 Homo sapiens (Human) 1252 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; A6QP79 CHOYP_CLC4K.2.2 m.55906 sp COL12_BOVIN 34.965 143 82 6 92 226 592 731 7.46E-20 90.9 COL12_BOVIN reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) COLEC12 CLP1 Bos taurus (Bovine) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; D2GXS7 CHOYP_contig_028897 m.32823 sp TRIM2_AILME 21.687 166 113 3 37 200 593 743 7.46E-06 49.7 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5E8K5 CHOYP_LOC100374409.2.2 m.66115 sp ANK3_MOUSE 29.693 293 169 6 25 317 456 711 7.46E-27 117 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; O75884 CHOYP_BRAFLDRAFT_277797.1.1 m.26394 sp RBBP9_HUMAN 58.989 178 73 0 2 179 6 183 7.46E-81 240 RBBP9_HUMAN reviewed Putative hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9) RBBP9 BOG RBBP10 Homo sapiens (Human) 186 regulation of cell proliferation [GO:0042127] GO:0005634; GO:0005730; GO:0005737; GO:0016787; GO:0042127; GO:0070062 0 0 0 PF06821; O88278 CHOYP_MBCDH9.1.1 m.46329 sp CELR3_RAT 25.926 405 268 13 139 523 593 985 7.46E-19 94.4 CELR3_RAT reviewed Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Celsr3 Megf2 Rattus norvegicus (Rat) 3313 axonal fasciculation [GO:0007413]; cell surface receptor signaling pathway [GO:0007166]; cilium assembly [GO:0042384]; dopaminergic neuron axon guidance [GO:0036514]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of protein phosphorylation [GO:0001932]; serotonergic neuron axon guidance [GO:0036515] GO:0001764; GO:0001932; GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007166; GO:0007413; GO:0016021; GO:0032880; GO:0036514; GO:0036515; GO:0042384 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF02793;PF00053;PF02210; Q09654 CHOYP_LOC100374741.56.83 m.53281 sp TRI23_CAEEL 24.413 213 146 8 25 226 118 326 7.46E-09 61.6 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q14118 CHOYP_DAG1.1.1 m.25786 sp DAG1_HUMAN 38.686 137 77 4 10 139 759 895 7.46E-10 58.9 DAG1_HUMAN reviewed Dystroglycan (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] DAG1 Homo sapiens (Human) 895 basement membrane organization [GO:0071711]; branching involved in salivary gland morphogenesis [GO:0060445]; calcium-dependent cell-matrix adhesion [GO:0016340]; commissural neuron axon guidance [GO:0071679]; cytoskeletal anchoring at plasma membrane [GO:0007016]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; extracellular matrix organization [GO:0030198]; membrane protein ectodomain proteolysis [GO:0006509]; microtubule anchoring [GO:0034453]; modulation by virus of host morphology or physiology [GO:0019048]; morphogenesis of an epithelial sheet [GO:0002011]; myelination in peripheral nervous system [GO:0022011]; negative regulation of cell migration [GO:0030336]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of protein kinase B signaling [GO:0051898]; nerve maturation [GO:0021682]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; protein O-linked glycosylation [GO:0006493]; regulation of embryonic cell shape [GO:0016476]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; response to peptide hormone [GO:0043434] GO:0001618; GO:0002011; GO:0003779; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005654; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005913; GO:0005925; GO:0006493; GO:0006509; GO:0006607; GO:0007016; GO:0008307; GO:0009279; GO:0010470; GO:0010717; GO:0015631; GO:0016010; GO:0016011; GO:0016021; GO:0016323; GO:0016340; GO:0016476; GO:0017166; GO:0019048; GO:0021682; GO:0022011; GO:0030027; GO:0030175; GO:0030198; GO:0030336; GO:0033268; GO:0034453; GO:0042169; GO:0042383; GO:0043034; GO:0043237; GO:0043409; GO:0043434; GO:0045121; GO:0045211; GO:0051393; GO:0051898; GO:0060441; GO:0060445; GO:0070062; GO:0070938; GO:0071679; GO:0071711; GO:1904261 0 0 0 PF05454; Q14191 CHOYP_NEMVEDRAFT_V1G200367.1.1 m.27782 sp WRN_HUMAN 38.261 115 61 5 21 132 588 695 7.46E-14 70.5 WRN_HUMAN reviewed "Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)" WRN RECQ3 RECQL2 Homo sapiens (Human) 1432 aging [GO:0007568]; base-excision repair [GO:0006284]; brain development [GO:0007420]; cell aging [GO:0007569]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; multicellular organism aging [GO:0010259]; nucleolus to nucleoplasm transport [GO:0032066]; positive regulation of hydrolase activity [GO:0051345]; protein sumoylation [GO:0016925]; regulation of apoptotic process [GO:0042981]; regulation of growth rate [GO:0040009]; regulation of signal transduction by p53 class mediator [GO:1901796]; replication fork processing [GO:0031297]; replicative cell aging [GO:0001302]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; strand displacement [GO:0000732]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722] GO:0000287; GO:0000403; GO:0000405; GO:0000722; GO:0000723; GO:0000731; GO:0000732; GO:0000784; GO:0001302; GO:0003677; GO:0003678; GO:0003682; GO:0004003; GO:0004386; GO:0004527; GO:0005524; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006302; GO:0006974; GO:0006979; GO:0007420; GO:0007568; GO:0007569; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0010259; GO:0016887; GO:0016925; GO:0030145; GO:0031297; GO:0032066; GO:0032403; GO:0040009; GO:0042803; GO:0042981; GO:0043005; GO:0043138; GO:0043140; GO:0051345; GO:0051880; GO:0071480; GO:1901796 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; Q29043 CHOYP_FUT1.1.2 m.14761 sp FUT1_PIG 30.216 278 171 9 49 317 87 350 7.46E-30 119 FUT1_PIG reviewed "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Sus scrofa (Pig) 365 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q6V0I7 CHOYP_NOTCH.3.6 m.44264 sp FAT4_HUMAN 55.263 76 28 2 187 261 3856 3926 7.46E-23 101 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q6XZF7 CHOYP_BRAFLDRAFT_91062.1.1 m.77 sp DNMBP_HUMAN 33.784 740 431 16 841 1555 639 1344 7.46E-113 398 DNMBP_HUMAN reviewed Dynamin-binding protein (Scaffold protein Tuba) DNMBP KIAA1010 Homo sapiens (Human) 1577 intracellular signal transduction [GO:0035556]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005795; GO:0005856; GO:0030054; GO:0035023; GO:0035556; GO:0045202 0 0 0 PF03114;PF00621;PF00018;PF07653;PF14604; Q96QF0 CHOYP_ISCW_ISCW014818.1.1 m.66358 sp RAB3I_HUMAN 50.888 169 69 2 71 239 160 314 7.46E-40 145 RAB3I_HUMAN reviewed Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein) RAB3IP RABIN8 Homo sapiens (Human) 476 cilium assembly [GO:0042384]; Golgi to plasma membrane transport [GO:0006893]; protein localization to organelle [GO:0033365]; protein targeting to membrane [GO:0006612] GO:0005634; GO:0005813; GO:0005829; GO:0005856; GO:0006612; GO:0006893; GO:0017112; GO:0030027; GO:0033365; GO:0036064; GO:0042384 0 0 0 PF06428; Q9WV92 CHOYP_41.1.3 m.15226 sp E41L3_MOUSE 58.529 340 135 4 4 342 120 454 7.46E-137 427 E41L3_MOUSE reviewed "Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]" Epb41l3 Dal1 Epb4.1l3 Kiaa0987 Mus musculus (Mouse) 929 apoptotic process [GO:0006915]; cortical actin cytoskeleton organization [GO:0030866]; cortical cytoskeleton organization [GO:0030865]; cytoskeletal anchoring at plasma membrane [GO:0007016]; myelin maintenance [GO:0043217]; neuron projection morphogenesis [GO:0048812]; paranodal junction assembly [GO:0030913]; protein localization to juxtaparanode region of axon [GO:0071205]; protein localization to paranode region of axon [GO:0002175]; protein localization to plasma membrane [GO:0072659]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360] GO:0001558; GO:0002175; GO:0005200; GO:0005737; GO:0005856; GO:0005886; GO:0005911; GO:0006915; GO:0007016; GO:0008360; GO:0014069; GO:0019898; GO:0030865; GO:0030866; GO:0030913; GO:0033270; GO:0043217; GO:0044224; GO:0048812; GO:0071205; GO:0072659 0 0 0 PF05902;PF08736;PF09380;PF00373;PF09379;PF04382; P09848 CHOYP_LOC587972.2.2 m.49039 sp LPH_HUMAN 49.053 528 240 5 2 526 996 1497 7.47E-171 532 LPH_HUMAN reviewed Lactase-phlorizin hydrolase (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)] LCT LPH Homo sapiens (Human) 1927 carbohydrate metabolic process [GO:0005975]; glycosyl compound metabolic process [GO:1901657]; polysaccharide digestion [GO:0044245]; response to drug [GO:0042493]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to iron(II) ion [GO:0010040]; response to lead ion [GO:0010288]; response to nickel cation [GO:0010045]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; response to sucrose [GO:0009744] GO:0000016; GO:0001666; GO:0005886; GO:0005887; GO:0005903; GO:0005975; GO:0007584; GO:0008422; GO:0009725; GO:0009744; GO:0010040; GO:0010045; GO:0010288; GO:0016020; GO:0016324; GO:0016740; GO:0017042; GO:0042493; GO:0042594; GO:0043627; GO:0044245; GO:0045471; GO:1901657 0 0 0 PF00232; P20664 CHOYP_LOC586401.1.2 m.15800 sp PRI1_MOUSE 44.66 206 97 7 2 196 218 417 7.47E-47 161 PRI1_MOUSE reviewed DNA primase small subunit (EC 2.7.7.-) (DNA primase 49 kDa subunit) (p49) Prim1 Mus musculus (Mouse) 417 0 GO:0003896; GO:0016020; GO:0046872; GO:1990077 0 0 cd04860; PF01896; P31809 CHOYP_BRAFLDRAFT_78749.3.5 m.34563 sp CEAM1_MOUSE 26.923 234 130 11 130 346 68 277 7.47E-07 56.2 CEAM1_MOUSE reviewed Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a) Ceacam1 Bgp Bgp1 Mus musculus (Mouse) 521 "bile acid and bile salt transport [GO:0015721]; blood vessel development [GO:0001568]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [GO:0016338]; cell-cell junction organization [GO:0045216]; cellular response to insulin stimulus [GO:0032869]; common myeloid progenitor cell proliferation [GO:0035726]; granulocyte colony-stimulating factor signaling pathway [GO:0038158]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; insulin catabolic process [GO:1901143]; insulin receptor internalization [GO:0038016]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation by host of viral process [GO:0044793]; negative regulation of bone resorption [GO:0045779]; negative regulation of cytokine production [GO:0001818]; negative regulation of cytotoxic T cell degranulation [GO:0043318]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of hepatocyte proliferation [GO:2000346]; negative regulation of interleukin-1 production [GO:0032692]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of JNK cascade [GO:0046329]; negative regulation of lipid biosynthetic process [GO:0051055]; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target [GO:0002859]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of vascular permeability [GO:0043116]; Peyer's patch development [GO:0048541]; positive regulation by host of viral process [GO:0044794]; positive regulation of activation-induced cell death of T cells [GO:0070237]; positive regulation of CD4-positive, alpha-beta T cell activation [GO:2000516]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD8-positive, alpha-beta T cell activation [GO:2001187]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of vasculogenesis [GO:2001214]; regulation of blood vessel remodeling [GO:0060312]; regulation of cell growth [GO:0001558]; regulation of endothelial cell differentiation [GO:0045601]; regulation of endothelial cell migration [GO:0010594]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of homophilic cell adhesion [GO:1903385]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; regulation of sprouting angiogenesis [GO:1903670]; viral entry into host cell [GO:0046718]; wound healing, spreading of cells [GO:0044319]" GO:0001558; GO:0001568; GO:0001618; GO:0001818; GO:0001915; GO:0002859; GO:0005130; GO:0005615; GO:0005886; GO:0005911; GO:0005912; GO:0006469; GO:0007156; GO:0009897; GO:0009925; GO:0009986; GO:0010594; GO:0014066; GO:0015125; GO:0015721; GO:0016020; GO:0016021; GO:0016324; GO:0016328; GO:0016338; GO:0016339; GO:0019900; GO:0019903; GO:0030054; GO:0030853; GO:0031005; GO:0031526; GO:0032692; GO:0032703; GO:0032869; GO:0035325; GO:0035726; GO:0038016; GO:0038158; GO:0042058; GO:0042102; GO:0042130; GO:0042803; GO:0043116; GO:0043318; GO:0043406; GO:0044319; GO:0044793; GO:0044794; GO:0044828; GO:0045216; GO:0045601; GO:0045671; GO:0045717; GO:0045779; GO:0046329; GO:0046330; GO:0046718; GO:0046790; GO:0046983; GO:0048541; GO:0050860; GO:0051024; GO:0051055; GO:0051533; GO:0060170; GO:0060312; GO:0070062; GO:0070237; GO:0070372; GO:0090331; GO:1901143; GO:1903385; GO:1903670; GO:1990782; GO:2000346; GO:2000516; GO:2000563; GO:2001187; GO:2001214 0 0 0 PF13895;PF07686; Q08C69 CHOYP_RUSD1.1.1 m.10471 sp RUSD1_DANRE 43.933 239 129 3 10 243 10 248 7.47E-63 201 RUSD1_DANRE reviewed RNA pseudouridylate synthase domain-containing protein 1 rpusd1 zgc:153465 Danio rerio (Zebrafish) (Brachydanio rerio) 293 tRNA pseudouridine synthesis [GO:0031119] GO:0003723; GO:0005739; GO:0009982; GO:0031119 0 0 0 PF00849; Q27245 CHOYP_BRAFLDRAFT_130974.1.1 m.28374 sp YH24_CAEEL 47.338 526 254 9 9 525 10 521 7.47E-154 452 YH24_CAEEL reviewed Putative aminopeptidase W07G4.4 (EC 3.4.11.-) lap-2 W07G4.4 Caenorhabditis elegans 522 0 GO:0004177; GO:0005737; GO:0008235; GO:0030145 0 0 cd00433; PF00883; Q29S05 CHOYP_CN37.1.1 m.40699 sp N42L1_BOVIN 46.154 65 34 1 78 141 42 106 7.47E-15 70.5 N42L1_BOVIN reviewed NEDD4-binding protein 2-like 1 N4BP2L1 Bos taurus (Bovine) 173 0 0 0 0 0 0 Q5M8V0 CHOYP_LOC100376610.2.3 m.19398 sp BT3L4_XENTR 85.47 117 17 0 1 117 1 117 7.47E-67 202 BT3L4_XENTR reviewed Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) btf3l4 TNeu120e23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 158 0 0 0 0 0 PF01849; Q5U4W1 CHOYP_PROSAPIP1.1.1 m.44521 sp LZTS2_XENLA 29.167 528 294 12 185 653 149 655 7.47E-33 137 LZTS2_XENLA reviewed Leucine zipper putative tumor suppressor 2 homolog (Protein lapser1) lzts2 lapser1 Xenopus laevis (African clawed frog) 666 cytokinesis [GO:0000910]; microtubule severing [GO:0051013]; mitotic nuclear division [GO:0007067]; negative regulation of Wnt signaling pathway [GO:0030178]; nuclear export [GO:0051168]; spindle midzone assembly [GO:0051255]; Wnt signaling pathway [GO:0016055] GO:0000910; GO:0005737; GO:0005813; GO:0005874; GO:0007067; GO:0016055; GO:0030178; GO:0030496; GO:0051013; GO:0051168; GO:0051255 0 0 0 0 Q5ZJ65 CHOYP_LOC580179.1.1 m.7327 sp FA76A_CHICK 68.902 164 44 3 1 164 1 157 7.47E-75 238 FA76A_CHICK reviewed Protein FAM76A FAM76A RCJMB04_20f16 Gallus gallus (Chicken) 307 protein desumoylation [GO:0016926] GO:0004175; GO:0005634; GO:0016926; GO:0016929 0 0 0 PF16046; Q8VHW4 CHOYP_CCG5.1.1 m.43764 sp CCG5_MOUSE 36.207 232 137 5 3 232 4 226 7.47E-37 133 CCG5_MOUSE reviewed Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) Cacng5 Mus musculus (Mouse) 275 calcium ion transmembrane transport [GO:0070588]; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311]; transmission of nerve impulse [GO:0019226] GO:0005245; GO:0014069; GO:0016247; GO:0019226; GO:0030054; GO:0032281; GO:0045211; GO:0070588; GO:2000311 0 0 0 PF00822; Q9D1Q1 CHOYP_MPH6.1.1 m.7092 sp MPH6_MOUSE 45.977 174 80 3 1 173 1 161 7.47E-37 127 MPH6_MOUSE reviewed M-phase phosphoprotein 6 Mphosph6 Mus musculus (Mouse) 161 maturation of 5.8S rRNA [GO:0000460] GO:0000176; GO:0000178; GO:0000460; GO:0003723; GO:0005634; GO:0005730; GO:0005737 0 0 0 PF10175; Q9ES88 CHOYP_S13A5.2.2 m.24561 sp S13A2_MOUSE 40.63 571 293 10 39 601 32 564 7.47E-133 405 S13A2_MOUSE reviewed Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter) Slc13a2 Nadc1 Sdct1 Mus musculus (Mouse) 586 0 GO:0005887; GO:0015361; GO:0070062 0 0 0 PF00939; A1ZA47 CHOYP_SMP_006860.2.3.4 m.63036 sp ZASP_DROME 36.471 85 53 1 5 88 4 88 7.48E-11 63.2 ZASP_DROME reviewed PDZ and LIM domain protein Zasp (Z band alternatively spliced PDZ-motif protein) Zasp52 Zasp CG30084 Drosophila melanogaster (Fruit fly) 2194 muscle structure development [GO:0061061]; myofibril assembly [GO:0030239]; regulation of cell-matrix adhesion [GO:0001952] GO:0001725; GO:0001952; GO:0003779; GO:0005915; GO:0005925; GO:0005927; GO:0008270; GO:0015629; GO:0016323; GO:0030018; GO:0030239; GO:0031252; GO:0045177; GO:0045178; GO:0051371; GO:0061061 0 0 0 PF15936;PF00412;PF00595; A4IHD2 CHOYP_ARIP4.1.3 m.5788 sp ARIP4_XENTR 58.929 168 67 1 90 255 780 947 7.48E-66 224 ARIP4_XENTR reviewed Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) rad54l2 arip4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1396 0 GO:0003677; GO:0004386; GO:0005524; GO:0005634 0 0 0 PF00271;PF00176; A4QNN3 CHOYP_UBP30.1.1 m.64094 sp UBP30_XENTR 45.07 71 38 1 43 112 67 137 7.48E-11 60.8 UBP30_XENTR reviewed Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) usp30 TEgg099b09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 519 mitochondrial fusion [GO:0008053]; mitophagy [GO:0000422]; protein deubiquitination [GO:0016579]; protein K11-linked deubiquitination [GO:0035871]; protein K6-linked deubiquitination [GO:0044313]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000422; GO:0004197; GO:0004843; GO:0005739; GO:0005741; GO:0006511; GO:0008053; GO:0016021; GO:0016579; GO:0035871; GO:0044313 0 0 0 PF00443; P05363 CHOYP_LOC762961.5.5 m.65992 sp NK2R_BOVIN 24.87 193 133 4 47 235 44 228 7.48E-11 67 NK2R_BOVIN reviewed Substance-K receptor (SKR) (NK-2 receptor) (NK-2R) (Neurokinin A receptor) (Tachykinin receptor 2) TACR2 TAC2R Bos taurus (Bovine) 384 cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; positive regulation of smooth muscle contraction [GO:0045987]; regulation of uterine smooth muscle contraction [GO:0070472] GO:0005887; GO:0007166; GO:0007268; GO:0016497; GO:0045987; GO:0070472 0 0 0 PF00001; P10982 CHOYP_ACTA.1.2 m.13069 sp ACT1_ABSGL 93.22 118 8 0 1 118 3 120 7.48E-83 241 ACT1_ABSGL reviewed Actin-1 (Fragment) ACT1 Absidia glauca (Pin mould) 140 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P27701 CHOYP_LOC100374248.1.5 m.19410 sp CD82_HUMAN 27.203 261 166 8 83 341 24 262 7.48E-23 99.4 CD82_HUMAN reviewed CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82) CD82 KAI1 SAR2 ST6 TSPAN27 Homo sapiens (Human) 267 cell surface receptor signaling pathway [GO:0007166] GO:0005886; GO:0005887; GO:0007166; GO:0070062 0 0 0 PF00335; P28824 CHOYP_NRP1.1.5 m.15445 sp NRP1_XENLA 29.528 254 147 11 69 308 27 262 7.48E-17 85.9 NRP1_XENLA reviewed Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) 928 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; endothelial cell chemotaxis [GO:0035767]; organ morphogenesis [GO:0009887]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005021; GO:0007411; GO:0008201; GO:0009887; GO:0016021; GO:0017154; GO:0035767; GO:0046872; GO:0048010 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P53563 CHOYP_ISCW_ISCW012366.1.1 m.3690 sp B2CL1_RAT 30.921 152 96 3 130 273 82 232 7.48E-17 80.9 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; Q5BIM1 CHOYP_LOC100213744.16.19 m.51878 sp TRI45_BOVIN 25.701 214 133 9 4 213 127 318 7.48E-06 52.4 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5ZMC3 CHOYP_LOC100893535.1.1 m.27957 sp WSDU1_CHICK 43.058 497 259 7 57 553 1 473 7.48E-130 390 WSDU1_CHICK reviewed "WD repeat, SAM and U-box domain-containing protein 1" WDSUB1 RCJMB04_2i21 Gallus gallus (Chicken) 476 0 GO:0004842 0 0 0 PF07647;PF04564;PF00400; Q6R796 CHOYP_Y118.1.1 m.30002 sp Y117_OSHVF 97.79 181 4 0 1 181 181 361 7.48E-128 366 Y117_OSHVF reviewed Putative RING finger protein ORF117 ORF117 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 371 0 GO:0008270 0 0 0 0 Q86X83 CHOYP_CEP63.2.2 m.35716 sp COMD2_HUMAN 63.317 199 73 0 1 199 1 199 7.48E-88 259 COMD2_HUMAN reviewed COMM domain-containing protein 2 COMMD2 HSPC042 My004 Homo sapiens (Human) 199 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006355 0 0 0 PF07258; Q94126 CHOYP_LOC100880607.1.1 m.25812 sp CES2_CAEEL 59.211 76 31 0 176 251 105 180 7.48E-25 100 CES2_CAEEL reviewed Cell death specification protein 2 ces-2 ZK909.4 Caenorhabditis elegans 211 apoptotic process [GO:0006915]; multicellular organism development [GO:0007275]; positive regulation of programmed cell death [GO:0043068] GO:0000977; GO:0001012; GO:0001077; GO:0003700; GO:0005634; GO:0006915; GO:0007275; GO:0043068; GO:0043565 0 0 0 PF07716; Q99PL6 CHOYP_LOC100524481.1.1 m.14740 sp UBXN6_MOUSE 41.203 449 243 11 4 439 1 441 7.48E-104 318 UBXN6_MOUSE reviewed UBX domain-containing protein 6 (UBX domain-containing protein 1) Ubxn6 Ubxd1 Ubxdc2 Mus musculus (Mouse) 442 0 GO:0005634; GO:0005737; GO:0005815; GO:0070062 0 0 0 PF09409;PF00789; Q9EQG7 CHOYP_HSPA8.1.1 m.62792 sp ENPP5_MOUSE 40.833 360 199 8 42 393 46 399 7.48E-91 286 ENPP5_MOUSE reviewed Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-) Enpp5 Mus musculus (Mouse) 477 cell communication [GO:0007154]; nucleotide catabolic process [GO:0009166] GO:0004551; GO:0005576; GO:0005887; GO:0007154; GO:0009166; GO:0046872 0 0 0 PF01663; Q9H246 CHOYP_contig_005093 m.5821 sp CA021_HUMAN 46.809 47 22 1 100 143 74 120 7.48E-06 46.6 CA021_HUMAN reviewed Uncharacterized protein C1orf21 (Cell proliferation-inducing gene 13 protein) C1orf21 PIG13 Homo sapiens (Human) 121 0 0 0 0 0 PF15389; A1L253 CHOYP_LOC100471454.1.1 m.5796 sp F149B_DANRE 50 84 37 2 110 192 89 168 7.49E-19 87 F149B_DANRE reviewed Protein FAM149B1 fam149b1 zgc:158651 Danio rerio (Zebrafish) (Brachydanio rerio) 644 0 0 0 0 0 PF12516; P09593 CHOYP_NEMVEDRAFT_V1G208691.1.10 m.313 sp SANT_PLAFV 38.278 209 114 4 15 223 110 303 7.49E-06 50.8 SANT_PLAFV reviewed S-antigen protein 0 Plasmodium falciparum (isolate v1) 375 0 GO:0020003 0 0 0 PF05756; P10394 CHOYP_LOC100535270.3.4 m.16249 sp POL4_DROME 28.981 697 435 13 1 652 509 1190 7.49E-80 280 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P17900 CHOYP_LOC100699750.2.2 m.46815 sp SAP3_HUMAN 22.599 177 122 6 18 193 29 191 7.49E-08 53.9 SAP3_HUMAN reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) [Cleaved into: Ganglioside GM2 activator isoform short] GM2A Homo sapiens (Human) 193 ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; learning or memory [GO:0007611]; lipid storage [GO:0019915]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; positive regulation of hydrolase activity [GO:0051345] GO:0005319; GO:0005739; GO:0005889; GO:0006687; GO:0006689; GO:0007611; GO:0009313; GO:0009898; GO:0016004; GO:0019915; GO:0030290; GO:0032428; GO:0043202; GO:0045179; GO:0050885; GO:0051345; GO:0070062 0 0 0 PF02221; Q26636 CHOYP_LOC575203.3.6 m.13352 sp CATL_SARPE 52.063 315 144 3 53 360 25 339 7.49E-119 350 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q4ZJM9 CHOYP_LOC100691474.1.1 m.153 sp C1QL4_MOUSE 32.061 131 82 4 59 186 109 235 7.49E-10 59.7 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5R8H3 CHOYP_BAP31.1.1 m.62939 sp BAP31_PONAB 48.98 245 116 3 1 236 1 245 7.49E-62 197 BAP31_PONAB reviewed B-cell receptor-associated protein 31 (BCR-associated protein 31) (Bap31) BCAP31 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 246 apoptotic process [GO:0006915]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0006886; GO:0006915; GO:0016021; GO:0016192; GO:0033116 0 0 0 PF05529; Q5ZLC6 CHOYP_ANKRD10.1.2 m.31096 sp ANR10_CHICK 38.521 257 131 4 8 260 7 240 7.49E-50 174 ANR10_CHICK reviewed Ankyrin repeat domain-containing protein 10 ANKRD10 RCJMB04_6l10 Gallus gallus (Chicken) 414 regulation of canonical Wnt signaling pathway [GO:0060828] GO:0060828 0 0 0 PF12796; Q64350 CHOYP_LOC579737.1.1 m.14356 sp EI2BE_RAT 40.087 686 376 12 30 687 38 716 7.49E-164 491 EI2BE_RAT reviewed Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon) Eif2b5 Eif2be Rattus norvegicus (Rat) 716 aging [GO:0007568]; astrocyte development [GO:0014002]; astrocyte differentiation [GO:0048708]; cellular response to drug [GO:0035690]; hippocampus development [GO:0021766]; myelination [GO:0042552]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of apoptotic process [GO:0043065]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to lithium ion [GO:0010226]; response to peptide hormone [GO:0043434]; translational initiation [GO:0006413] GO:0001541; GO:0003743; GO:0005085; GO:0005634; GO:0005737; GO:0005851; GO:0006413; GO:0007568; GO:0009408; GO:0009749; GO:0010226; GO:0014002; GO:0014003; GO:0021766; GO:0031369; GO:0034976; GO:0035690; GO:0042552; GO:0043065; GO:0043434; GO:0045727; GO:0045948; GO:0048708 0 0 0 PF00132;PF02020; Q6NVU2 CHOYP_PPP1CC.1.1 m.13938 sp PPIG_XENTR 96.035 227 9 0 1 227 1 227 7.49E-164 458 PPIG_XENTR reviewed Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) ppp1cc TEgg061c20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 323 angiogenesis [GO:0001525]; cell division [GO:0051301]; glycogen metabolic process [GO:0005977]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope reassembly [GO:0007084]; protein dephosphorylation [GO:0006470] GO:0000777; GO:0001525; GO:0004722; GO:0005730; GO:0005739; GO:0005977; GO:0006470; GO:0007067; GO:0007084; GO:0016607; GO:0030496; GO:0032154; GO:0046872; GO:0051301 0 0 0 PF00149;PF16891; Q8JFN7 CHOYP_ACH91.1.1 m.48865 sp ACH91_ONCMY 35 360 225 5 6 364 7 358 7.49E-74 249 ACH91_ONCMY reviewed Neuronal acetylcholine receptor subunit alpha-9-I (Nicotinic acetylcholine receptor subunit alpha-9-I) (NACHR alpha-9-I) nachra9 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 572 0 GO:0004889; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF02931;PF02932; Q95WA0 CHOYP_LOC585872.1.6 m.21451 sp RL26_LITLI 81.56 141 24 1 1 139 1 141 7.49E-81 237 RL26_LITLI reviewed 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) 144 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 0 PF00467;PF16906; Q95WA0 CHOYP_LOC585872.5.6 m.58875 sp RL26_LITLI 81.56 141 24 1 1 139 1 141 7.49E-81 237 RL26_LITLI reviewed 60S ribosomal protein L26 RPL26 Littorina littorea (Common periwinkle) 144 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015934 0 0 0 PF00467;PF16906; Q9NUV9 CHOYP_LOC100711088.1.1 m.21214 sp GIMA4_HUMAN 38.462 260 151 4 72 330 30 281 7.49E-54 183 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; A0JNH9 CHOYP_BRAFLDRAFT_122376.1.1 m.49446 sp APLF_BOVIN 35.632 87 41 1 15 101 352 423 7.50E-09 61.6 APLF_BOVIN reviewed Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) APLF Bos taurus (Bovine) 485 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; single strand break repair [GO:0000012] GO:0000012; GO:0000166; GO:0003906; GO:0004520; GO:0005634; GO:0005829; GO:0006302; GO:0006974; GO:0008408; GO:0046872 0 0 0 PF10283; B2IZD3 CHOYP_LOC100370751.4.4 m.61289 sp BDLP_NOSP7 28.934 197 116 6 145 337 68 244 7.50E-14 79.7 BDLP_NOSP7 reviewed Bacterial dynamin-like protein (BDLP) (EC 3.6.5.5) Npun_R6513 Nostoc punctiforme (strain ATCC 29133 / PCC 73102) 693 0 GO:0003924; GO:0005525; GO:0005886; GO:0008289; GO:0016021 0 0 0 PF00350; D2GXS7 CHOYP_LOC100376214.9.11 m.53354 sp TRIM2_AILME 22.353 255 184 6 162 404 492 744 7.50E-10 64.3 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D8VNT0 CHOYP_BRAFLDRAFT_86061.11.13 m.58043 sp FCNV4_CERRY 48.357 213 103 5 89 298 128 336 7.50E-62 202 FCNV4_CERRY reviewed Ryncolin-4 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; P04755 CHOYP_LOC100533245.2.6 m.30397 sp ACH3_DROME 53.425 219 92 2 1 219 1 209 7.50E-76 241 ACH3_DROME reviewed Acetylcholine receptor subunit beta-like 1 (Nicotinic acetylcholine receptor beta 1) nAChRbeta1 Acr64B AcrD ard nAcRbeta-64B CG11348 Drosophila melanogaster (Fruit fly) 521 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P07686 CHOYP_ISCW_ISCW004208.2.3 m.35012 sp HEXB_HUMAN 53.782 119 54 1 8 126 437 554 7.50E-40 142 HEXB_HUMAN reviewed Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] HEXB HCC7 Homo sapiens (Human) 556 astrocyte cell migration [GO:0043615]; cellular calcium ion homeostasis [GO:0006874]; cellular protein metabolic process [GO:0044267]; chondroitin sulfate catabolic process [GO:0030207]; ganglioside catabolic process [GO:0006689]; glycosphingolipid metabolic process [GO:0006687]; hyaluronan catabolic process [GO:0030214]; keratan sulfate catabolic process [GO:0042340]; lipid storage [GO:0019915]; locomotory behavior [GO:0007626]; lysosome organization [GO:0007040]; male courtship behavior [GO:0008049]; myelination [GO:0042552]; neuromuscular process controlling balance [GO:0050885]; oligosaccharide catabolic process [GO:0009313]; oogenesis [GO:0048477]; penetration of zona pellucida [GO:0007341]; phospholipid biosynthetic process [GO:0008654]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell shape [GO:0008360]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501] GO:0001501; GO:0001669; GO:0004563; GO:0006687; GO:0006689; GO:0006874; GO:0007040; GO:0007341; GO:0007605; GO:0007626; GO:0008049; GO:0008360; GO:0008375; GO:0008654; GO:0009313; GO:0016020; GO:0019915; GO:0030207; GO:0030214; GO:0042340; GO:0042552; GO:0042582; GO:0042803; GO:0043202; GO:0043615; GO:0044267; GO:0045944; GO:0046982; GO:0048477; GO:0050885; GO:0070062 0 0 0 PF00728;PF14845; P19217 CHOYP_SULT1E1.2.3 m.17697 sp ST1E1_BOVIN 30.605 281 171 9 24 290 19 289 7.50E-37 135 ST1E1_BOVIN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) 295 estrogen metabolic process [GO:0008210] GO:0004304; GO:0005496; GO:0005737; GO:0008210; GO:0050294 0 0 0 PF00685; P56389 CHOYP_LOC100693418.1.2 m.990 sp CDD_MOUSE 57.037 135 58 0 4 138 10 144 7.50E-54 169 CDD_MOUSE reviewed Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) Cda Cdd Mus musculus (Mouse) 146 cytidine deamination [GO:0009972]; negative regulation of cell growth [GO:0030308]; negative regulation of nucleotide metabolic process [GO:0045980]; protein homotetramerization [GO:0051289] GO:0001882; GO:0004126; GO:0005829; GO:0008270; GO:0009972; GO:0030308; GO:0042802; GO:0042803; GO:0045980; GO:0051289 0 0 0 PF00383; Q08874 CHOYP_MITF.1.3 m.25689 sp MITF_MOUSE 41.304 322 149 8 95 379 94 412 7.50E-64 218 MITF_MOUSE reviewed Microphthalmia-associated transcription factor Mitf Bw Mi Vit Mus musculus (Mouse) 526 "bone remodeling [GO:0046849]; camera-type eye development [GO:0043010]; canonical Wnt signaling pathway involved in negative regulation of apoptotic process [GO:0044336]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; mast cell migration [GO:0097531]; melanocyte differentiation [GO:0030318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; osteoclast differentiation [GO:0030316]; pigmentation [GO:0043473]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein complex assembly [GO:0006461]; regulation of cell proliferation [GO:0042127]; regulation of gene expression [GO:0010468]; regulation of osteoclast differentiation [GO:0045670]; regulation of RNA biosynthetic process [GO:2001141]; regulation of transcription, DNA-templated [GO:0006355]; Wnt signaling pathway [GO:0016055]" GO:0000122; GO:0000978; GO:0000979; GO:0001077; GO:0003677; GO:0003682; GO:0003700; GO:0003705; GO:0005634; GO:0006355; GO:0006461; GO:0010468; GO:0010628; GO:0016055; GO:0030154; GO:0030316; GO:0030318; GO:0042127; GO:0043010; GO:0043066; GO:0043234; GO:0043473; GO:0043565; GO:0044336; GO:0045165; GO:0045670; GO:0045893; GO:0045944; GO:0046849; GO:0097531; GO:2000144; GO:2001141 0 0 0 PF11851;PF00010;PF15951; Q26636 CHOYP_LOC579572.1.1 m.14907 sp CATL_SARPE 52.571 175 76 3 53 220 25 199 7.50E-55 181 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q2EY13 CHOYP_PRTG.2.3 m.27411 sp PRTGB_DANRE 28.972 963 601 29 40 958 38 961 7.50E-108 369 PRTGB_DANRE reviewed Protogenin B (Fragment) prtgb Danio rerio (Zebrafish) (Brachydanio rerio) 1069 multicellular organism development [GO:0007275] GO:0007275; GO:0016021 0 0 0 PF00041;PF07679; Q3KPR5 CHOYP_BIVM.3.3 m.63239 sp BIVM_XENLA 53.435 262 122 0 41 302 133 394 7.50E-99 302 BIVM_XENLA reviewed Basic immunoglobulin-like variable motif-containing protein bivm Xenopus laevis (African clawed frog) 497 0 GO:0005634; GO:0005737 0 0 0 0 Q54YM7 CHOYP_LOC100375740.2.2 m.45575 sp TM2D2_DICDI 50.769 65 32 0 110 174 46 110 7.50E-13 69.3 TM2D2_DICDI reviewed TM2 domain-containing protein DDB_G0278163 DDB_G0278163 Dictyostelium discoideum (Slime mold) 161 0 GO:0016021 0 0 0 PF05154; Q62417 CHOYP_LOC100867381.5.8 m.37859 sp SRBS1_MOUSE 41.434 251 116 7 1480 1720 980 1209 7.50E-44 179 SRBS1_MOUSE reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) Sorbs1 Kiaa1296 Sh3d5 Mus musculus (Mouse) 1290 cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005856; GO:0005886; GO:0005913; GO:0005924; GO:0005925; GO:0008134; GO:0008286; GO:0015758; GO:0016020; GO:0016363; GO:0019901; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q6P8E9 CHOYP_LOC100371232.1.1 m.25817 sp NH2L1_XENTR 82.813 128 21 1 51 177 1 128 7.50E-76 226 NH2L1_XENTR reviewed NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) snu13 nhp2l1 TGas123b15.1 TNeu005n20.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 128 "maturation of LSU-rRNA [GO:0000470]; maturation of SSU-rRNA [GO:0030490]; mRNA splicing, via spliceosome [GO:0000398]" GO:0000398; GO:0000470; GO:0003723; GO:0030490; GO:0031428; GO:0032040; GO:0046540; GO:0071011 0 0 0 PF01248; Q6QRN8 CHOYP_PHUM_PHUM012540.1.4 m.6964 sp LAP4A_BOVIN 31.839 223 133 4 103 325 18 221 7.50E-28 111 LAP4A_BOVIN reviewed Lysosomal-associated transmembrane protein 4A LAPTM4A Bos taurus (Bovine) 233 transport [GO:0006810] GO:0005794; GO:0006810; GO:0016020; GO:0016021 0 0 0 PF03821; Q7T141 CHOYP_GLIPR1L1.1.1 m.41745 sp PI15A_DANRE 38.547 179 88 6 36 195 72 247 7.50E-31 117 PI15A_DANRE reviewed Peptidase inhibitor 15-A pi15a pi15 si:rp71-1m12.1 Danio rerio (Zebrafish) (Brachydanio rerio) 260 0 GO:0005576; GO:0030414 0 0 0 PF00188; Q8NHV1 CHOYP_GIMA4.1.7 m.3736 sp GIMA7_HUMAN 35.268 224 131 3 58 281 7 216 7.50E-41 149 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q8R0M8 CHOYP_LOAG_06921.1.1 m.34559 sp MOT5_MOUSE 24.765 533 348 14 8 533 14 500 7.50E-36 143 MOT5_MOUSE reviewed Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) 500 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; Q8TDB6 CHOYP_LOC100370200.3.5 m.53032 sp DTX3L_HUMAN 52.151 186 87 2 1723 1908 556 739 7.50E-54 206 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q9CYF5 CHOYP_LOC489793.1.1 m.8096 sp WBS16_MOUSE 45.227 440 218 8 82 503 26 460 7.50E-133 395 WBS16_MOUSE reviewed Williams-Beuren syndrome chromosomal region 16 protein homolog Wbscr16 Mus musculus (Mouse) 461 0 GO:0005087; GO:0005739; GO:0044822 0 0 0 PF00415; Q9D3D9 CHOYP_DWIL_GK24980.1.1 m.44159 sp ATPD_MOUSE 47.967 123 64 0 25 147 46 168 7.50E-32 114 ATPD_MOUSE reviewed "ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit)" Atp5d Mus musculus (Mouse) 168 ATP synthesis coupled proton transport [GO:0015986]; proton transport [GO:0015992] GO:0000275; GO:0005739; GO:0005740; GO:0005743; GO:0005753; GO:0015078; GO:0015986; GO:0015992; GO:0045259; GO:0046933; GO:0046961 0 0 cd12152; PF02823; A1L1W9 CHOYP_BRAFLDRAFT_120361.1.1 m.45643 sp MOT10_DANRE 30.256 390 261 5 66 446 84 471 7.51E-59 212 MOT10_DANRE reviewed Monocarboxylate transporter 10 (MCT 10) (Solute carrier family 16 member 10) slc16a10 si:ch211-241j12.1 zgc:158478 Danio rerio (Zebrafish) (Brachydanio rerio) 505 ion transmembrane transport [GO:0034220] GO:0005215; GO:0005887; GO:0015173; GO:0015349; GO:0016021; GO:0034220 0 0 cd06174; PF07690; A1ZAX0 CHOYP_PHUM_PHUM579960.1.1 m.40392 sp CCH1R_DROME 35.735 347 198 9 34 364 83 420 7.51E-64 214 CCH1R_DROME reviewed Neuropeptide CCHamide-1 receptor CCHa1-R CG30106 Drosophila melanogaster (Fruit fly) 499 G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218] GO:0005887; GO:0007186; GO:0007218; GO:0008188; GO:0008261; GO:0016021 0 0 0 PF00001; F7EL49 CHOYP_AHCTF1.1.1 m.17462 sp AF1L1_XENTR 22.715 361 186 15 346 685 232 520 7.51E-09 63.5 AF1L1_XENTR reviewed Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) afap1l1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 758 0 GO:0002102; GO:0005737; GO:0030054; GO:0071437 0 0 0 PF00169; P10079 CHOYP_FBP1.3.7 m.26985 sp FBP1_STRPU 31.847 157 100 4 329 482 107 259 7.51E-13 75.5 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P40983 CHOYP_BRAFLDRAFT_88492.1.1 m.15305 sp YOR6_CALSR 27.805 205 111 7 77 276 43 215 7.51E-09 61.6 YOR6_CALSR reviewed Uncharacterized protein in xynA 3'region (ORF6) (Fragment) 0 Caldicellulosiruptor sp. (strain Rt8B.4) 402 0 0 0 0 0 PF00350; P42674 CHOYP_LOC752805.1.3 m.18032 sp BP10_PARLI 33.878 245 141 8 1 237 192 423 7.51E-31 123 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; Q08024 CHOYP_PEBB.2.2 m.39895 sp PEBB_MOUSE 64.286 168 59 1 42 209 1 167 7.51E-76 230 PEBB_MOUSE reviewed Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) Cbfb Pebp2b Pebpb2 Mus musculus (Mouse) 187 cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0001503; GO:0001649; GO:0003677; GO:0003712; GO:0003713; GO:0005634; GO:0016020; GO:0016513; GO:0030098; GO:0030099; GO:0045944; GO:0048469; GO:0060216 0 0 0 PF02312; Q3T106 CHOYP_LOC579411.1.1 m.4137 sp SRSF7_BOVIN 56.522 69 30 0 12 80 12 80 7.51E-20 91.3 SRSF7_BOVIN reviewed "Serine/arginine-rich splicing factor 7 (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Bos taurus (Bovine) 235 "mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA splicing [GO:0008380]" GO:0000166; GO:0005654; GO:0005737; GO:0006397; GO:0008270; GO:0008380; GO:0044822; GO:0048025; GO:0051028; GO:0070062 0 0 0 PF00076; Q6DIB5 CHOYP_MEG10.42.91 m.42152 sp MEG10_MOUSE 37.46 315 174 15 41 350 187 483 7.51E-37 147 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6ZRF8 CHOYP_TRI36.2.3 m.45224 sp RN207_HUMAN 27.273 209 128 10 45 246 103 294 7.51E-11 68.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8SWR3 CHOYP_LOC100900279.1.1 m.16376 sp SPR_DROME 26.398 322 212 11 21 326 91 403 7.51E-20 94 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q8WQI5 CHOYP_RS8.12.14 m.59494 sp RS8_SPOFR 67.429 175 55 1 40 214 1 173 7.51E-78 236 RS8_SPOFR reviewed 40S ribosomal protein S8 RpS8 Spodoptera frugiperda (Fall armyworm) 208 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01201; B3EWZ5 CHOYP_NEMVEDRAFT_V1G199073.1.1 m.33549 sp MLRP1_ACRMI 32.927 164 87 7 46 190 3138 3297 7.52E-14 77 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B4KCD5 CHOYP_NCBP2.1.1 m.60410 sp NCBP2_DROMO 77.483 151 34 0 27 177 2 152 7.52E-86 252 NCBP2_DROMO reviewed Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) Cbp20 GI23717 Drosophila mojavensis (Fruit fly) 154 "7-methylguanosine mRNA capping [GO:0006370]; gene silencing by RNA [GO:0031047]; mRNA cis splicing, via spliceosome [GO:0045292]" GO:0000166; GO:0000339; GO:0005634; GO:0005846; GO:0006370; GO:0031047; GO:0045292 0 0 0 PF00076; O08863 CHOYP_LOC100882826.1.2 m.60035 sp BIRC3_MOUSE 34.278 353 201 11 521 848 254 600 7.52E-47 180 BIRC3_MOUSE reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 2) (C-IAP2) (Inhibitor of apoptosis protein 1) (mIAP1) Birc3 Mus musculus (Mouse) 600 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of necroptotic process [GO:0060546]; negative regulation of phosphorylation [GO:0042326]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of necroptotic process [GO:0060544]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016740; GO:0016874; GO:0031398; GO:0034121; GO:0042326; GO:0042981; GO:0043027; GO:0060544; GO:0060546; GO:0070266; GO:1990001; GO:2000378 0 0 0 PF00653;PF00619; O75382 CHOYP_BRAFLDRAFT_87295.5.9 m.39283 sp TRIM3_HUMAN 29.008 131 84 4 134 256 614 743 7.52E-09 60.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06916 CHOYP_contig_037940 m.42805 sp FIRA_PLAFF 55.263 76 34 0 30 105 29 104 7.52E-14 70.9 FIRA_PLAFF reviewed 300 kDa antigen AG231 (Fragment) FIRA Plasmodium falciparum (isolate FC27 / Papua New Guinea) 310 0 0 0 0 0 PF07016; Q0VAA2 CHOYP_BRAFLDRAFT_87451.3.4 m.26859 sp LR74A_HUMAN 34.406 404 257 5 67 467 86 484 7.52E-70 234 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q8NA58 CHOYP_LOC100891016.2.2 m.56304 sp PNDC1_HUMAN 34.2 500 299 13 36 522 11 493 7.52E-86 278 PNDC1_HUMAN reviewed Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 PNLDC1 Homo sapiens (Human) 520 0 GO:0003676; GO:0005634; GO:0016021 0 0 0 PF04857; Q99M80 CHOYP_LOC100890753.1.3 m.50299 sp PTPRT_MOUSE 43.182 264 147 2 366 627 894 1156 7.52E-62 226 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9JLC8 CHOYP_LOC558150.1.4 m.34343 sp SACS_MOUSE 38.596 171 102 2 1 170 177 345 7.52E-28 114 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9R0P6 CHOYP_CPT1A.1.1 m.53985 sp SC11A_MOUSE 86.592 179 24 0 41 219 1 179 7.52E-106 305 SC11A_MOUSE reviewed Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) (Sid 2895) Sec11a Sec11l1 Sid2895 Spc18 Mus musculus (Mouse) 179 signal peptide processing [GO:0006465] GO:0005789; GO:0006465; GO:0008236; GO:0016021; GO:0031090; GO:0070062 0 0 0 PF00717; Q9VN14 CHOYP_LOC100875931.1.1 m.55195 sp CONT_DROME 32.794 1113 668 26 128 1216 299 1355 7.52E-163 525 CONT_DROME reviewed Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) 1390 axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nerve maturation [GO:0021682]; septate junction assembly [GO:0019991] GO:0005886; GO:0005918; GO:0008366; GO:0019991; GO:0021682; GO:0031225; GO:0045197; GO:0060857; GO:0061343 0 0 0 PF00041;PF00047;PF00059; D2GXS7 CHOYP_BRAFLDRAFT_241726.21.22 m.52291 sp TRIM2_AILME 24.335 263 168 9 18 261 492 742 7.53E-11 65.5 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75096 CHOYP_BRAFLDRAFT_92837.1.1 m.15404 sp LRP4_HUMAN 27.32 765 489 29 68 809 482 1202 7.53E-60 231 LRP4_HUMAN reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7) LRP4 KIAA0816 LRP10 MEGF7 Homo sapiens (Human) 1905 BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; proximal/distal pattern formation [GO:0009954]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001942; GO:0005509; GO:0006897; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030279; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0043025; GO:0048813; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; P21613 CHOYP_KINH.2.9 m.3665 sp KINH_DORPE 61.268 142 46 4 332 473 711 843 7.53E-34 139 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P51871 CHOYP_LOC100562694.1.1 m.20092 sp CP4F6_RAT 44.022 368 193 6 30 387 124 488 7.53E-106 326 CP4F6_RAT reviewed Cytochrome P450 4F6 (EC 1.14.14.1) (CYPIVF6) Cyp4f6 Rattus norvegicus (Rat) 537 inflammatory response [GO:0006954]; leukotriene metabolic process [GO:0006691] GO:0005506; GO:0005789; GO:0006691; GO:0006954; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P55210 CHOYP_CASP7.9.23 m.25523 sp CASP7_HUMAN 30.04 253 135 10 2 230 67 301 7.53E-20 89.4 CASP7_HUMAN reviewed Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] CASP7 MCH3 Homo sapiens (Human) 303 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; execution phase of apoptosis [GO:0097194]; proteolysis [GO:0006508] GO:0004197; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0008635; GO:0097194; GO:0097200 0 0 0 0 P97576 CHOYP_LOC100619435.1.2 m.28884 sp GRPE1_RAT 49.767 215 102 4 16 226 3 215 7.53E-58 185 GRPE1_RAT reviewed "GrpE protein homolog 1, mitochondrial (Mt-GrpE#1)" Grpel1 Grepel1 Rattus norvegicus (Rat) 217 protein folding [GO:0006457] GO:0000774; GO:0005759; GO:0006457 0 0 cd00446; PF01025; Q02763 CHOYP_TIE2.3.6 m.47265 sp TIE2_HUMAN 27.651 481 296 14 884 1338 642 1096 7.53E-46 184 TIE2_HUMAN reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 Homo sapiens (Human) 1124 angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; leukocyte migration [GO:0050900]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; organ regeneration [GO:0031100]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000165; GO:0001525; GO:0001666; GO:0001934; GO:0001935; GO:0001938; GO:0001958; GO:0002040; GO:0004672; GO:0004713; GO:0004714; GO:0004872; GO:0005088; GO:0005524; GO:0005576; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007165; GO:0007169; GO:0007267; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016323; GO:0016324; GO:0016525; GO:0018108; GO:0031100; GO:0032878; GO:0034446; GO:0043066; GO:0043114; GO:0043434; GO:0043552; GO:0043627; GO:0045121; GO:0045766; GO:0046777; GO:0048014; GO:0050728; GO:0050900; GO:0051259; GO:0051591; GO:0051894; GO:0051897; GO:0060216; GO:0060347; GO:0070374; GO:0072012; GO:1902533; GO:2000251; GO:2000351; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q2THW9 CHOYP_LOC100478743.1.1 m.12302 sp ZDHC5_CANLF 55.594 286 122 2 3 286 12 294 7.53E-104 330 ZDHC5_CANLF reviewed Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) ZDHHC5 Canis lupus familiaris (Dog) (Canis familiaris) 715 protein palmitoylation [GO:0018345] GO:0005737; GO:0005886; GO:0008270; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q6R7G0 CHOYP_Y068.6.6 m.41596 sp Y068_OSHVF 22.204 626 394 17 166 713 27 637 7.53E-35 145 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q8JHV9 CHOYP_BIRC7.3.5 m.22701 sp BIR7A_XENLA 32.83 265 160 7 78 327 139 400 7.53E-39 144 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8K2I9 CHOYP_FBXO18.1.2 m.45454 sp FBH1_MOUSE 31.548 168 109 4 236 400 192 356 7.53E-16 83.2 FBH1_MOUSE reviewed F-box DNA helicase 1 (EC 3.6.4.12) (F-box only protein 18) Fbxo18 Fbh1 Fbx18 Mus musculus (Mouse) 1042 "cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of chromatin binding [GO:0035562]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; replication fork protection [GO:0048478]; response to intra-S DNA damage checkpoint signaling [GO:0072429]" GO:0000724; GO:0000737; GO:0000785; GO:0001934; GO:0003678; GO:0003690; GO:0003697; GO:0004003; GO:0005524; GO:0005634; GO:0006974; GO:0008219; GO:0015616; GO:0016567; GO:0019005; GO:0031297; GO:0035562; GO:0043138; GO:0048478; GO:0072429; GO:1902231; GO:2000042 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8NFZ0}. 0 0 PF12937;PF13361; Q8VD04 CHOYP_GRAP1.1.1 m.45768 sp GRAP1_MOUSE 40.705 823 398 19 23 788 1 790 7.53E-131 412 GRAP1_MOUSE reviewed GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein) Gripap1 DXImx47e Kiaa1167 Mus musculus (Mouse) 806 0 GO:0005769; GO:0072562 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208197.17.21 m.59023 sp HS12B_HUMAN 32.099 486 264 14 11 437 61 539 7.53E-69 234 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99715 CHOYP_MATN1.5.5 m.63658 sp COCA1_HUMAN 31.61 503 282 12 23 471 123 617 7.53E-56 209 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; F6QEU4 CHOYP_LOC100373444.64.79 m.60167 sp LIN41_XENTR 22.699 163 101 4 32 184 216 363 7.54E-07 53.1 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; P48725 CHOYP_LOC582174.5.16 m.32684 sp PCNT_MOUSE 39.326 178 97 6 34 205 2694 2866 7.54E-25 107 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; Q2FXL6 CHOYP_LOC100180023.4.7 m.33650 sp Y1819_STAA8 30.303 165 85 5 15 177 7 143 7.54E-10 58.2 Y1819_STAA8 reviewed Putative universal stress protein SAOUHSC_01819 SAOUHSC_01819 Staphylococcus aureus (strain NCTC 8325) 166 response to stress [GO:0006950] GO:0005737; GO:0006950 0 0 0 PF00582; Q6NTY6 CHOYP_LOC100214436.1.1 m.20290 sp EGR1B_XENLA 75.701 107 26 0 333 439 268 374 7.54E-54 190 EGR1B_XENLA reviewed Early growth response protein 1-B (EGR-1-B) egr1-b Xenopus laevis (African clawed frog) 475 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF11914;PF11928; Q8K078 CHOYP_LOC100533290.1.1 m.9002 sp SO4A1_MOUSE 35.962 634 386 7 25 654 96 713 7.54E-136 419 SO4A1_MOUSE reviewed Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Mus musculus (Mouse) 723 organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327] GO:0005887; GO:0008514; GO:0015347; GO:0015349; GO:0015711; GO:0042403; GO:0043252; GO:0070327 0 0 cd06174; PF07648;PF03137; Q8K3K9 CHOYP_LOC100934456.1.2 m.60998 sp GIMA4_RAT 27.193 228 152 5 195 412 13 236 7.54E-17 84 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8NFD2 CHOYP_TVAG_168010.8.45 m.32595 sp ANKK1_HUMAN 44.954 109 60 0 11 119 413 521 7.54E-22 92.8 ANKK1_HUMAN reviewed Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (Sugen kinase 288) (SgK288) (X-kinase) ANKK1 PKK2 SGK288 Homo sapiens (Human) 765 0 GO:0004674; GO:0005524 0 0 0 PF12796;PF07714; Q8R500 CHOYP_MFN2.1.1 m.15292 sp MFN2_RAT 46.863 271 131 1 4 261 485 755 7.54E-87 276 MFN2_RAT reviewed Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) Mfn2 Fzo1a Rattus norvegicus (Rat) 757 apoptotic process [GO:0006915]; autophagy [GO:0006914]; mitochondrial fusion [GO:0008053]; mitochondrial membrane organization [GO:0007006]; negative regulation of cell proliferation [GO:0008285]; negative regulation of smooth muscle cell proliferation [GO:0048662]; protein targeting to mitochondrion [GO:0006626]; response to unfolded protein [GO:0006986] GO:0003924; GO:0005525; GO:0005739; GO:0005741; GO:0005829; GO:0006626; GO:0006914; GO:0006915; GO:0006986; GO:0007006; GO:0008053; GO:0008285; GO:0016021; GO:0031306; GO:0048662; GO:0051020 0 0 0 PF00350;PF04799; Q91WN1 CHOYP_DNJC9.1.1 m.12688 sp DNJC9_MOUSE 54.118 255 116 1 27 280 2 256 7.54E-98 290 DNJC9_MOUSE reviewed DnaJ homolog subfamily C member 9 Dnajc9 Mus musculus (Mouse) 259 positive regulation of ATPase activity [GO:0032781]; social behavior [GO:0035176] GO:0005615; GO:0005634; GO:0005737; GO:0005886; GO:0031072; GO:0032781; GO:0035176 0 0 cd06257; PF00226; Q9H0F5 CHOYP_LOC100376112.1.1 m.13534 sp RNF38_HUMAN 41.684 487 232 19 138 591 48 515 7.54E-71 239 RNF38_HUMAN reviewed E3 ubiquitin-protein ligase RNF38 (EC 6.3.2.-) (RING finger protein 38) RNF38 Homo sapiens (Human) 515 "male gonad development [GO:0008584]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]" GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0006355; GO:0008270; GO:0008584; GO:0016567; GO:0016874; GO:0036126; GO:0043161; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q9NL98 CHOYP_ISCW_ISCW010532.3.4 m.56458 sp PRDX_ASCSU 74.359 195 50 0 31 225 1 195 7.54E-110 316 PRDX_ASCSU reviewed Peroxiredoxin (EC 1.11.1.15) (AsPrx) (Thioredoxin peroxidase) 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 195 cell redox homeostasis [GO:0045454]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005737; GO:0006979; GO:0008379; GO:0016209; GO:0045454 0 0 0 PF10417;PF00578; O01761 CHOYP_LOC100176083.1.1 m.64380 sp UNC89_CAEEL 27.833 600 388 16 14 590 5501 6078 7.55E-56 208 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O15973 CHOYP_OPSD1.1.2 m.25197 sp OPSD1_MIZYE 26.163 344 209 12 35 355 56 377 7.55E-24 105 OPSD1_MIZYE reviewed "Rhodopsin, GQ-coupled (GQ-rhodopsin)" SCOP1 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 499 phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601] GO:0004930; GO:0007601; GO:0007602; GO:0009881; GO:0016021; GO:0018298 0 0 0 PF00001; O18973 CHOYP_RABX5.1.2 m.26033 sp RABX5_BOVIN 48.276 493 225 11 44 514 4 488 7.55E-154 452 RABX5_BOVIN reviewed Rab5 GDP/GTP exchange factor (Rabex-5) RABGEF1 RABEX5 Bos taurus (Bovine) 492 endocytosis [GO:0006897]; protein transport [GO:0015031] GO:0003677; GO:0005769; GO:0006897; GO:0008270; GO:0015031; GO:0055037 0 0 0 PF02204;PF01754; O57521 CHOYP_SC31A.1.2 m.8241 sp HS90B_DANRE 76.718 262 56 2 1 258 465 725 7.55E-140 412 HS90B_DANRE reviewed Heat shock protein HSP 90-beta hsp90ab1 hsp90b Danio rerio (Zebrafish) (Brachydanio rerio) 725 blood vessel development [GO:0001568]; leukocyte migration [GO:0050900]; muscle organ development [GO:0007517]; protein folding [GO:0006457]; response to estrogen [GO:0043627]; response to stress [GO:0006950] GO:0001568; GO:0005524; GO:0005634; GO:0005737; GO:0006457; GO:0006950; GO:0007517; GO:0043627; GO:0050900 0 0 0 PF02518;PF00183; O88665 CHOYP_LOC100116878.1.1 m.11654 sp BRD7_MOUSE 34.426 671 347 17 5 623 3 632 7.55E-108 343 BRD7_MOUSE reviewed Bromodomain-containing protein 7 (75 kDa bromodomain protein) Brd7 Bp75 Mus musculus (Mouse) 651 "cell cycle [GO:0007049]; negative regulation of cell proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of histone acetylation [GO:0035066]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0002039; GO:0003713; GO:0003714; GO:0005634; GO:0005737; GO:0006351; GO:0006357; GO:0007049; GO:0008134; GO:0008285; GO:0016055; GO:0035066; GO:0042393; GO:0044212; GO:0045892; GO:0045893; GO:0070577; GO:0090544; GO:2000134 0 0 0 PF00439;PF12024; P38542 CHOYP_DHX8.2.3 m.55114 sp RAN_BRUMA 86.792 212 28 0 2 213 4 215 7.55E-141 395 RAN_BRUMA reviewed GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Bm1_44725 Brugia malayi (Filarial nematode worm) 215 intracellular protein transport [GO:0006886]; nucleocytoplasmic transport [GO:0006913]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0006886; GO:0006913; GO:0007264 0 0 0 PF00071; P98187 CHOYP_BRAFLDRAFT_61250.2.14 m.14011 sp CP4F8_HUMAN 41.365 469 251 9 20 472 30 490 7.55E-122 369 CP4F8_HUMAN reviewed Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8) CYP4F8 Homo sapiens (Human) 520 icosanoid metabolic process [GO:0006690]; prostaglandin metabolic process [GO:0006693] GO:0005506; GO:0005789; GO:0006690; GO:0006693; GO:0016021; GO:0018685; GO:0019825; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q13263 CHOYP_LOC100374981.13.16 m.63836 sp TIF1B_HUMAN 24.257 202 144 6 1 197 135 332 7.55E-11 64.3 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q14BI2 CHOYP_contig_051146 m.61021 sp GRM2_MOUSE 26.147 218 142 5 407 614 194 402 7.55E-09 62.4 GRM2_MOUSE reviewed Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 Mus musculus (Mouse) 872 "glutamate secretion [GO:0014047]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0001641; GO:0005246; GO:0005622; GO:0005887; GO:0014047; GO:0030054; GO:0030424; GO:0030425; GO:0042734; GO:0043005; GO:0051966 0 0 0 PF00003;PF01094;PF07562; Q571H0 CHOYP_URB1.1.3 m.13554 sp NPA1P_MOUSE 26.706 674 436 17 1 654 201 836 7.55E-65 237 NPA1P_MOUSE reviewed Nucleolar pre-ribosomal-associated protein 1 (URB1 ribosome biogenesis 1 homolog) Urb1 Kiaa0539 Npa1 Mus musculus (Mouse) 2274 0 GO:0005730; GO:0044822 0 0 0 PF16201;PF11707; Q5NVI3 CHOYP_RED.2.2 m.62514 sp RED_PONAB 57.821 358 119 6 27 378 1 332 7.55E-120 370 RED_PONAB reviewed Protein Red (Cytokine IK) (IK factor) IK Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 557 0 GO:0005634 0 0 0 PF07807;PF07808; Q69Z37 CHOYP_BRAFLDRAFT_131039.1.9 m.20864 sp SAM9L_MOUSE 27.389 157 91 5 399 533 678 833 7.55E-07 57 SAM9L_MOUSE reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) Samd9l Kiaa2005 Mus musculus (Mouse) 1561 common myeloid progenitor cell proliferation [GO:0035726]; endosomal vesicle fusion [GO:0034058]; hematopoietic progenitor cell differentiation [GO:0002244]; regulation of protein catabolic process [GO:0042176]; spleen development [GO:0048536]; stem cell division [GO:0017145] GO:0002244; GO:0005769; GO:0017145; GO:0034058; GO:0035726; GO:0042176; GO:0048536 0 0 0 0 Q8IZJ3 CHOYP_BRAFLDRAFT_75652.1.1 m.22739 sp CPMD8_HUMAN 35.714 112 69 3 190 299 978 1088 7.55E-11 66.6 CPMD8_HUMAN reviewed C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 CPAMD8 KIAA1283 Homo sapiens (Human) 1885 0 GO:0004867; GO:0005615; GO:0005886 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF07648;PF12248;PF10569; Q8N806 CHOYP_UBR7.1.1 m.7300 sp UBR7_HUMAN 47.63 422 177 8 51 430 5 424 7.55E-117 351 UBR7_HUMAN reviewed Putative E3 ubiquitin-protein ligase UBR7 (EC 6.3.2.-) (N-recognin-7) UBR7 C14orf130 Homo sapiens (Human) 425 protein ubiquitination [GO:0016567] GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02207; Q8TEB9 CHOYP_LOC100376736.1.1 m.29094 sp RHBL4_HUMAN 44.86 321 155 8 1 308 1 312 7.55E-84 258 RHBL4_HUMAN reviewed Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4) RHBDD1 RHBDL4 HSD-50 HSD50 Homo sapiens (Human) 315 "apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; ERAD pathway [GO:0036503]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein processing [GO:0010954]; positive regulation of secretion [GO:0051047]; post-translational protein modification [GO:0043687]; spermatid differentiation [GO:0048515]" GO:0004175; GO:0004252; GO:0005739; GO:0005783; GO:0005789; GO:0006915; GO:0010954; GO:0030176; GO:0031293; GO:0033619; GO:0034620; GO:0034644; GO:0036503; GO:0043066; GO:0043687; GO:0044322; GO:0045732; GO:0048515; GO:0051047; GO:1904211 0 0 0 PF01694; Q9BV38 CHOYP_BRAFLDRAFT_82717.1.1 m.16532 sp WDR18_HUMAN 38.584 438 241 8 27 456 6 423 7.55E-104 319 WDR18_HUMAN reviewed WD repeat-containing protein 18 WDR18 Homo sapiens (Human) 432 multicellular organism development [GO:0007275]; rRNA processing [GO:0006364] GO:0005654; GO:0005737; GO:0006364; GO:0007275 0 0 0 PF00400;PF14077; Q9FE17 CHOYP_LOC100632618.1.3 m.23426 sp SIR1_ARATH 39.583 240 126 5 95 333 21 242 7.55E-44 161 SIR1_ARATH reviewed NAD-dependent protein deacetylase SRT1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) SRT1 At5g55760 MDF20.20 Arabidopsis thaliana (Mouse-ear cress) 473 0 GO:0005634; GO:0016787; GO:0046872; GO:0070403 0 0 0 PF02146; Q9ULJ7 CHOYP_TVAG_268170.1.1 m.40052 sp ANR50_HUMAN 29.412 136 95 1 67 202 965 1099 7.55E-12 68.9 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; O75382 CHOYP_BRAFLDRAFT_205965.30.43 m.52694 sp TRIM3_HUMAN 27.723 101 69 2 272 370 622 720 7.56E-06 51.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P15880 CHOYP_LOC658809.1.1 m.35060 sp RS2_HUMAN 90.374 187 18 0 1 187 61 247 7.56E-123 351 RS2_HUMAN reviewed 40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) RPS2 RPS4 Homo sapiens (Human) 293 "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of transferase activity [GO:0051347]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0003729; GO:0003735; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005913; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0017134; GO:0019083; GO:0019899; GO:0022627; GO:0044822; GO:0051347; GO:0070062; GO:0098641 0 0 0 PF00333;PF03719; Q0E908 CHOYP_SMP_149990.1.1.1 m.44960 sp HIL_DROME 41.148 209 113 3 18 218 331 537 7.56E-48 170 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q32KI9 CHOYP_LOC100378957.1.1 m.62805 sp ARSI_MOUSE 38.858 543 240 11 26 541 45 522 7.56E-119 365 ARSI_MOUSE reviewed Arylsulfatase I (ASI) (EC 3.1.6.-) Arsi Mus musculus (Mouse) 573 metabolic process [GO:0008152] GO:0005576; GO:0005783; GO:0008152; GO:0008484; GO:0046872 0 0 0 PF00884; Q4H3K6 CHOYP_LOC100369767.1.4 m.4323 sp FGFR_CIOIN 33.443 305 175 7 1020 1304 372 668 7.56E-46 181 FGFR_CIOIN reviewed Fibroblast growth factor receptor (Ci-FGFR) (EC 2.7.10.1) FGFR Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) 747 positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0008284; GO:0016021 0 0 0 PF07679;PF07714; Q4UMH6 CHOYP_ANK3.2.9 m.4510 sp Y381_RICFE 25.888 394 261 14 273 666 760 1122 7.56E-21 101 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5ZJ24 CHOYP_FOPNL.1.1 m.28176 sp FOPNL_CHICK 61.446 83 32 0 1 83 51 133 7.56E-28 102 FOPNL_CHICK reviewed LisH domain-containing protein FOPNL (FGFR1OP N-terminal-like protein) FOPNL RCJMB04_21j4 Gallus gallus (Chicken) 175 cilium assembly [GO:0042384]; microtubule anchoring [GO:0034453] GO:0031514; GO:0034451; GO:0034453; GO:0036064; GO:0042384 0 0 0 PF09398; Q64459 CHOYP_CP3AB.1.4 m.2790 sp CP3AB_MOUSE 39.147 516 283 9 1 507 1 494 7.56E-124 374 CP3AB_MOUSE reviewed Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (Cytochrome P-450IIIAM1) (Cytochrome P-450UT) Cyp3a11 Cyp3a-11 Mus musculus (Mouse) 504 0 GO:0004497; GO:0005506; GO:0005789; GO:0016491; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q6GQN4 CHOYP_XPF.1.1 m.14801 sp FA32A_DANRE 52.991 117 47 3 1 117 1 109 7.56E-26 96.3 FA32A_DANRE reviewed Protein FAM32A-like fam32al fam32a zgc:91831 Danio rerio (Zebrafish) (Brachydanio rerio) 109 apoptotic process [GO:0006915]; cell cycle [GO:0007049] GO:0005730; GO:0006915; GO:0007049 0 0 0 PF08555; Q96M91 CHOYP_LOC100368885.1.1 m.7807 sp CFA53_HUMAN 32.271 502 330 4 10 505 11 508 7.56E-55 195 CFA53_HUMAN reviewed Cilia- and flagella-associated protein 53 (Coiled-coil domain-containing protein 11) CFAP53 CCDC11 Homo sapiens (Human) 514 cilium assembly [GO:0042384]; cilium movement [GO:0003341] GO:0003341; GO:0005929; GO:0042384 0 0 0 0 Q9MYM7 CHOYP_LOC552398.1.2 m.25066 sp B3GT1_PONPY 29.615 260 149 6 67 309 79 321 7.56E-36 134 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; P15989 CHOYP_LOC100486063.4.9 m.29599 sp CO6A3_CHICK 26.108 609 375 30 134 698 38 615 7.57E-30 130 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; Q01105 CHOYP_ISCW_ISCW021350.1.1 m.10332 sp SET_HUMAN 65.128 195 65 1 34 225 42 236 7.57E-92 278 SET_HUMAN reviewed Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) SET Homo sapiens (Human) 290 "DNA replication [GO:0006260]; negative regulation of histone acetylation [GO:0035067]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; nucleosome disassembly [GO:0006337]; regulation of mRNA stability [GO:0043488]; viral process [GO:0016032]" GO:0003677; GO:0004864; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0006260; GO:0006334; GO:0006337; GO:0006913; GO:0008601; GO:0016032; GO:0035067; GO:0042393; GO:0043234; GO:0043488; GO:0043524; GO:0045892; GO:0048471 0 0 0 PF00956; Q6DMN8 CHOYP_LOC100368576.1.1 m.45391 sp SPAT4_PANTR 40.449 267 140 4 17 282 45 293 7.57E-61 198 SPAT4_PANTR reviewed Spermatogenesis-associated protein 4 SPATA4 Pan troglodytes (Chimpanzee) 305 0 GO:0005737 0 0 0 PF06294; Q6R7B1 CHOYP_Y115.1.2 m.28736 sp Y115_OSHVF 98.883 179 2 0 1 179 75 253 7.57E-132 372 Y115_OSHVF reviewed Uncharacterized protein ORF115 ORF115 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 253 DNA replication [GO:0006260] GO:0003688; GO:0005524; GO:0006260 0 0 0 PF02399; Q8BHW2 CHOYP_TRIADDRAFT_50333.1.1 m.59774 sp OSCP1_MOUSE 58.205 390 139 9 1 379 1 377 7.57E-155 444 OSCP1_MOUSE reviewed Protein OSCP1 Oscp1 Mus musculus (Mouse) 379 positive regulation of protein targeting to mitochondrion [GO:1903955]; transport [GO:0006810] GO:0006810; GO:0009925; GO:1903955 0 0 0 PF10188; B3EWZ5 CHOYP_MDGA2.1.2 m.5343 sp MLRP1_ACRMI 36.145 166 99 4 33 192 1114 1278 7.58E-24 101 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O01393 CHOYP_LOC100533354.6.6 m.63681 sp UNC9_CAEEL 40.533 375 211 2 37 411 20 382 7.58E-96 295 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; O44252 CHOYP_LOC754845.1.3 m.14862 sp ROST_DROME 26.4 125 80 5 180 298 123 241 7.58E-06 50.4 ROST_DROME reviewed Protein rolling stone rost CG9552 Drosophila melanogaster (Fruit fly) 275 myoblast fusion [GO:0007520]; skeletal muscle tissue development [GO:0007519] GO:0007519; GO:0007520; GO:0016020; GO:0016021 0 0 0 0 O88843 CHOYP_LOC100373670.1.1 m.2427 sp CRADD_MOUSE 26.415 159 100 5 171 321 40 189 7.58E-07 52.4 CRADD_MOUSE reviewed Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) Cradd Raidd Mus musculus (Mouse) 199 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; positive regulation of apoptotic signaling pathway [GO:2001235]" GO:0002020; GO:0005634; GO:0005737; GO:0006915; GO:0006919; GO:0006977; GO:0030674; GO:0070513; GO:0071260; GO:2001235 0 0 0 PF00619;PF00531; P02463 CHOYP_CO4A4.1.1 m.1570 sp CO4A1_MOUSE 41.855 399 166 10 115 480 845 1210 7.58E-36 147 CO4A1_MOUSE reviewed Collagen alpha-1(IV) chain [Cleaved into: Arresten] Col4a1 Mus musculus (Mouse) 1669 basement membrane organization [GO:0071711]; blood vessel morphogenesis [GO:0048514]; brain development [GO:0007420]; cellular response to amino acid stimulus [GO:0071230]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; epithelial cell differentiation [GO:0030855]; extracellular matrix organization [GO:0030198]; neuromuscular junction development [GO:0007528]; patterning of blood vessels [GO:0001569]; renal tubule morphogenesis [GO:0061333]; retinal blood vessel morphogenesis [GO:0061304] GO:0001569; GO:0005201; GO:0005576; GO:0005587; GO:0005604; GO:0007420; GO:0007528; GO:0030198; GO:0030855; GO:0031012; GO:0038063; GO:0048407; GO:0048514; GO:0061304; GO:0061333; GO:0071230; GO:0071711 0 0 0 PF01413;PF01391; Q28178 CHOYP_SSPO.2.14 m.3787 sp TSP1_BOVIN 53.097 113 52 1 441 553 435 546 7.58E-28 123 TSP1_BOVIN reviewed Thrombospondin-1 THBS1 TSP-1 TSP1 Bos taurus (Bovine) 1170 behavioral response to pain [GO:0048266]; cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986] GO:0005509; GO:0005615; GO:0005783; GO:0006954; GO:0006986; GO:0007155; GO:0008201; GO:0016525; GO:0016529; GO:0034976; GO:0048266; GO:0050840 0 0 0 PF12662;PF00090;PF02412;PF05735;PF00093; Q2T9T9 CHOYP_LOC590729.1.1 m.35259 sp FBXW9_BOVIN 35.519 366 233 2 60 423 90 454 7.58E-84 267 FBXW9_BOVIN reviewed F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) FBXW9 Bos taurus (Bovine) 458 0 0 0 0 0 PF00400; Q61555 CHOYP_BRAFLDRAFT_98740.4.7 m.53694 sp FBN2_MOUSE 29.709 1168 624 55 140 1182 1811 2906 7.58E-87 318 FBN2_MOUSE reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] Fbn2 Fbn-2 Mus musculus (Mouse) 2907 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; limb morphogenesis [GO:0035108]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0030326; GO:0030501; GO:0031012; GO:0035108; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346 0 0 0 PF12662;PF07645;PF12661;PF00683; Q6AZ60 CHOYP_BRAFLDRAFT_99630.9.9 m.62562 sp EGFL7_RAT 36.559 93 51 5 54 139 87 178 7.58E-06 52 EGFL7_RAT reviewed Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) Egfl7 Cbl20 Megf7 Rattus norvegicus (Rat) 279 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001938; GO:0005509; GO:0005576; GO:0005615; GO:0007155; GO:0031012; GO:0045746 0 0 0 PF07974;PF07645;PF07546; Q9C098 CHOYP_BRAFLDRAFT_71623.2.2 m.38827 sp DCLK3_HUMAN 65.169 267 93 0 591 857 351 617 7.58E-120 381 DCLK3_HUMAN reviewed Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) DCLK3 DCAMKL3 DCDC3C KIAA1765 Homo sapiens (Human) 648 0 GO:0004674; GO:0005524; GO:0005634; GO:0005737 0 0 0 PF00069; Q9ESN6 CHOYP_BRAFLDRAFT_88224.8.11 m.47073 sp TRIM2_MOUSE 25.352 213 126 7 241 441 514 705 7.58E-09 61.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A0JPE1 CHOYP_LOC101067651.1.1 m.52408 sp FA69B_XENTR 26.158 367 237 7 68 410 66 422 7.59E-43 158 FA69B_XENTR reviewed Protein FAM69B fam69b Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 431 0 GO:0005789; GO:0016021 0 0 0 PF12260;PF14875; A2XYY8 CHOYP_DDB_G0276237.1.1 m.11000 sp ANM61_ORYSI 41.818 330 181 3 9 328 48 376 7.59E-85 266 ANM61_ORYSI reviewed Probable protein arginine N-methyltransferase 6.1 (EC 2.1.1.-) PRMT6.1 H0402C08.4 OsI_017281 Oryza sativa subsp. indica (Rice) 379 protein methylation [GO:0006479] GO:0006479; GO:0008168 0 0 0 0 O00115 CHOYP_LOC100891282.1.1 m.41107 sp DNS2A_HUMAN 37.87 338 197 6 19 349 16 347 7.59E-82 256 DNS2A_HUMAN reviewed Deoxyribonuclease-2-alpha (EC 3.1.22.1) (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2) DNASE2 DNASE2A DNL2 Homo sapiens (Human) 360 apoptotic DNA fragmentation [GO:0006309]; DNA metabolic process [GO:0006259]; erythrocyte differentiation [GO:0030218] GO:0003677; GO:0004531; GO:0005764; GO:0006259; GO:0006309; GO:0030218; GO:0070062 0 0 0 PF03265; P10079 CHOYP_LOC100634060.31.37 m.65091 sp FBP1_STRPU 54.517 321 146 0 1 321 217 537 7.59E-106 335 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P70604 CHOYP_KCNN2.1.1 m.37308 sp KCNN2_RAT 37.379 412 241 7 103 507 117 518 7.59E-85 276 KCNN2_RAT reviewed Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) Kcnn2 Rattus norvegicus (Rat) 580 potassium ion transport [GO:0006813]; regulation of neuronal synaptic plasticity [GO:0048168] GO:0005516; GO:0005886; GO:0006813; GO:0016021; GO:0016286; GO:0043025; GO:0043197; GO:0048168 0 0 0 PF02888;PF07885;PF03530; Q4LDE5 CHOYP_LOC100367084.12.22 m.48659 sp SVEP1_HUMAN 24.891 687 414 25 205 804 435 1106 7.59E-37 156 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q6DGK9 CHOYP_CK049.1.1 m.35912 sp CK049_DANRE 51.399 286 124 4 5 282 6 284 7.59E-98 296 CK049_DANRE reviewed UPF0705 protein C11orf49 homolog zgc:92873 Danio rerio (Zebrafish) (Brachydanio rerio) 331 0 0 0 0 0 0 Q6PFY8 CHOYP_DDB_G0289647.1.1 m.3939 sp TRI45_MOUSE 25 156 113 4 3 157 186 338 7.59E-09 58.2 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8SWR3 CHOYP_LOC100118228.3.3 m.55864 sp SPR_DROME 28.378 296 167 10 29 305 165 434 7.59E-24 103 SPR_DROME reviewed Sex peptide receptor SPR CG16752 Drosophila melanogaster (Fruit fly) 435 "G-protein coupled receptor signaling pathway [GO:0007186]; negative regulation of female receptivity, post-mating [GO:0045434]; regulation of post-mating oviposition [GO:0048042]" GO:0005886; GO:0007186; GO:0008528; GO:0016021; GO:0045434; GO:0048042 0 0 0 PF10324; Q9ESN6 CHOYP_TRIM3.27.58 m.32876 sp TRIM2_MOUSE 25.714 245 163 8 30 268 511 742 7.59E-11 65.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_contig_022554 m.25781 sp TRIM2_MOUSE 27.442 215 139 9 93 299 534 739 7.59E-06 51.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A6QQY2 CHOYP_SI_RP71-68N21.9.1.1 m.39642 sp KLH13_BOVIN 38.075 239 134 3 2 229 308 543 7.60E-45 164 KLH13_BOVIN reviewed Kelch-like protein 13 KLHL13 Bos taurus (Bovine) 655 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O70439 CHOYP_BRAFLDRAFT_59863.1.1 m.24545 sp STX7_MOUSE 45.627 263 134 4 23 281 4 261 7.60E-71 222 STX7_MOUSE reviewed Syntaxin-7 Stx7 Syn7 Mus musculus (Mouse) 261 intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000149; GO:0001772; GO:0001916; GO:0005484; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0006886; GO:0006906; GO:0012505; GO:0016021; GO:0019869; GO:0019905; GO:0030139; GO:0031201; GO:0031901; GO:0031982; GO:0042582; GO:0043231; GO:0048278; GO:0048471; GO:0051640; GO:0055037; GO:0070062; GO:0070820; GO:0070925; GO:1902685; GO:1903076 0 0 0 PF05739; P54645 CHOYP_BRAFLDRAFT_239705.1.1 m.7440 sp AAPK1_RAT 57.534 146 56 3 5 146 347 490 7.60E-47 164 AAPK1_RAT reviewed 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) Prkaa1 Ampk1 Rattus norvegicus (Rat) 559 "autophagy [GO:0006914]; cellular response to ethanol [GO:0071361]; cellular response to glucose starvation [GO:0042149]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to nutrient levels [GO:0031669]; cellular response to organonitrogen compound [GO:0071417]; cellular response to prostaglandin E stimulus [GO:0071380]; cholesterol biosynthetic process [GO:0006695]; cold acclimation [GO:0009631]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; fatty acid oxidation [GO:0019395]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; intracellular signal transduction [GO:0035556]; lipid biosynthetic process [GO:0008610]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glucose import in response to insulin stimulus [GO:2001274]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of TOR signaling [GO:0032007]; negative regulation of translation [GO:0017148]; positive regulation of autophagy [GO:0010508]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of gene expression [GO:0010628]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of glucose import [GO:0046326]; positive regulation of glycolytic process [GO:0045821]; positive regulation of skeletal muscle tissue development [GO:0048643]; protein heterooligomerization [GO:0051291]; protein phosphorylation [GO:0006468]; regulation of circadian rhythm [GO:0042752]; regulation of energy homeostasis [GO:2000505]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of transcription, DNA-templated [GO:0006355]; regulation of vesicle-mediated transport [GO:0060627]; response to activity [GO:0014823]; response to caffeine [GO:0031000]; response to camptothecin [GO:1901563]; response to gamma radiation [GO:0010332]; response to UV [GO:0009411]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]" GO:0003682; GO:0004674; GO:0004679; GO:0005524; GO:0005634; GO:0005737; GO:0006006; GO:0006351; GO:0006355; GO:0006468; GO:0006633; GO:0006695; GO:0006914; GO:0008022; GO:0008284; GO:0008610; GO:0009411; GO:0009631; GO:0010332; GO:0010508; GO:0010628; GO:0014823; GO:0016055; GO:0016324; GO:0017148; GO:0019395; GO:0019900; GO:0031000; GO:0031588; GO:0031669; GO:0032007; GO:0033135; GO:0035174; GO:0035556; GO:0042149; GO:0042557; GO:0042593; GO:0042752; GO:0043066; GO:0043234; GO:0045722; GO:0045821; GO:0046321; GO:0046326; GO:0046872; GO:0047322; GO:0048511; GO:0048643; GO:0050321; GO:0050405; GO:0050995; GO:0051291; GO:0055089; GO:0060627; GO:0070301; GO:0071361; GO:0071380; GO:0071417; GO:0071456; GO:1901563; GO:2000505; GO:2001274 0 0 0 PF16579;PF00069; P84875 CHOYP_WFIKKN1.1.1 m.28942 sp PCPI_SABMA 31.579 190 93 6 181 370 3 155 7.60E-18 83.6 PCPI_SABMA reviewed Carboxypeptidase inhibitor SmCI 0 Sabellastarte magnifica (Feather duster) 165 0 GO:0004867; GO:0008191 0 0 0 PF00014; P86788 CHOYP_GIGA5.2.4 m.17226 sp GIGA5_CRAGI 93.333 75 4 1 71 145 40 113 7.60E-42 137 GIGA5_CRAGI reviewed Gigasin-5 (Fragment) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 113 0 0 0 0 0 0 Q68FR3 CHOYP_INT12.1.1 m.14804 sp INT12_RAT 37.931 261 89 8 32 266 8 221 7.60E-43 162 INT12_RAT reviewed Integrator complex subunit 12 (Int12) (PHD finger protein 22) Ints12 Phf22 Rattus norvegicus (Rat) 461 0 GO:0005634; GO:0008270 0 0 0 PF00628; Q6AYG0 CHOYP_LOC100370823.3.3 m.62659 sp RRNAD_RAT 32.922 243 127 6 59 289 15 233 7.60E-31 127 RRNAD_RAT reviewed Protein RRNAD1 Rrnad1 Rattus norvegicus (Rat) 475 0 GO:0016021 0 0 0 PF13679; Q86VP3 CHOYP_LOC100373559.1.1 m.23755 sp PACS2_HUMAN 43.088 434 216 10 374 794 469 884 7.60E-103 340 PACS2_HUMAN reviewed Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein) PACS2 KIAA0602 PACS1L Homo sapiens (Human) 889 apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; protein localization to pre-autophagosomal structure [GO:0034497]; protein targeting to plasma membrane [GO:0072661]; viral process [GO:0016032] GO:0000045; GO:0005739; GO:0005783; GO:0005788; GO:0006915; GO:0016032; GO:0034497; GO:0044325; GO:0072661 0 0 0 PF10254; Q920A5 CHOYP_RISC.1.1 m.42512 sp RISC_MOUSE 43.021 437 217 10 22 436 24 450 7.60E-106 324 RISC_MOUSE reviewed Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1) Scpep1 Risc Mus musculus (Mouse) 452 negative regulation of blood pressure [GO:0045776]; positive regulation of vasodilation [GO:0045909]; proteolysis involved in cellular protein catabolic process [GO:0051603]; retinoic acid metabolic process [GO:0042573] GO:0004185; GO:0005829; GO:0042573; GO:0045776; GO:0045909; GO:0051603; GO:0070062 0 0 0 PF00450; Q9NXS3 CHOYP_NEMVEDRAFT_V1G120526.4.5 m.36926 sp KLH28_HUMAN 29.457 129 87 3 11 136 15 142 7.60E-08 58.9 KLH28_HUMAN reviewed Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) 571 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0031463; GO:0042787 0 0 0 PF07707;PF00651;PF01344; A2AJ76 CHOYP_HMCN2.8.12 m.39297 sp HMCN2_MOUSE 25.589 1528 898 70 272 1730 445 1802 7.61E-77 289 HMCN2_MOUSE reviewed Hemicentin-2 Hmcn2 Mus musculus (Mouse) 5100 response to stimulus [GO:0050896] GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; A8WHR0 CHOYP_DCA17.1.1 m.12730 sp DCA17_DANRE 34.608 497 301 13 34 521 44 525 7.61E-83 273 DCA17_DANRE reviewed DDB1- and CUL4-associated factor 17 dcaf17 si:ch211-245g15.4 Danio rerio (Zebrafish) (Brachydanio rerio) 526 protein ubiquitination [GO:0016567] GO:0005730; GO:0016021; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15802; A9ULE9 CHOYP_NEMVEDRAFT_V1G234616.1.1 m.31509 sp DJC22_XENTR 30.226 354 212 11 4 342 5 338 7.61E-37 139 DJC22_XENTR reviewed DnaJ homolog subfamily C member 22 dnajc22 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 340 0 GO:0016021 0 0 cd06257; PF00226;PF05154; O70277 CHOYP_BRAFLDRAFT_85511.16.23 m.53834 sp TRIM3_RAT 28.333 120 81 3 41 157 627 744 7.61E-07 50.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P07463 CHOYP_TSP_08523.1.1 m.59107 sp CALM_PARTE 35.461 141 87 3 45 182 5 144 7.61E-22 89.7 CALM_PARTE reviewed Calmodulin (CaM) CAM GSPATT00015825001 Paramecium tetraurelia 149 0 GO:0005509 0 0 0 PF13499; P17972 CHOYP_LOC100374549.1.1 m.920 sp KCNAW_DROME 48.292 439 213 5 24 457 8 437 7.61E-141 421 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; P56213 CHOYP_LOC100704551.1.1 m.30906 sp ALR_MOUSE 55.932 177 63 3 1 177 36 197 7.61E-66 202 ALR_MOUSE reviewed FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) Gfer Alr MNCb-0663 Mus musculus (Mouse) 198 0 GO:0005737; GO:0005739; GO:0005758; GO:0015035; GO:0016972; GO:0050660 0 0 0 PF04777; Q13263 CHOYP_LOC100373444.62.79 m.59070 sp TIF1B_HUMAN 23.671 207 126 8 2 191 139 330 7.61E-06 52.8 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q14162 CHOYP_MEGF6A.1.2 m.17795 sp SREC_HUMAN 36 100 49 3 181 267 242 339 7.61E-10 64.3 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q4R4T6 CHOYP_DDX28.1.1 m.16414 sp DDX28_MACFA 36.09 532 318 12 6 522 12 536 7.61E-101 317 DDX28_MACFA reviewed Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) DDX28 QccE-21131 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 546 mitochondrial large ribosomal subunit assembly [GO:1902775] GO:0004386; GO:0005524; GO:0005634; GO:0019843; GO:0032047; GO:0035770; GO:0042645; GO:1902775 0 0 0 PF00270;PF00271; Q61P40 CHOYP_ACDOPBH.6.9 m.45878 sp TBH1_CAEBR 30.272 294 190 7 159 440 199 489 7.61E-32 133 TBH1_CAEBR reviewed Tyramine beta-hydroxylase (EC 1.14.17.-) tbh-1 CBG07714 Caenorhabditis briggsae 585 neurotransmitter biosynthetic process [GO:0042136] GO:0005507; GO:0008021; GO:0016715; GO:0030054; GO:0042136 0 0 0 PF03712;PF01082;PF03351; Q6GMV2 CHOYP_BRAFLDRAFT_74594.1.3 m.1187 sp SMYD5_HUMAN 25.183 409 229 19 305 675 21 390 7.61E-16 84 SMYD5_HUMAN reviewed SET and MYND domain-containing protein 5 (EC 2.1.1.-) (Protein NN8-4AG) (Retinoic acid-induced protein 15) SMYD5 RAI15 Homo sapiens (Human) 418 0 GO:0008168; GO:0046872 0 0 0 PF00856; Q7Z7K0 CHOYP_LOC100908156.1.1 m.33674 sp COXM1_HUMAN 40.449 89 53 0 39 127 4 92 7.61E-16 72.8 COXM1_HUMAN reviewed COX assembly mitochondrial protein homolog (Cmc1p) CMC1 C3orf68 Homo sapiens (Human) 106 0 GO:0005739; GO:0046872 0 0 0 PF08583; Q95LU3 CHOYP_FBCD1.3.3 m.52533 sp FBCD1_MACFA 33.728 338 187 9 14 323 98 426 7.61E-55 187 FBCD1_MACFA reviewed Fibrinogen C domain-containing protein 1 FIBCD1 QtsA-17952 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 431 0 GO:0008061; GO:0016020; GO:0016021; GO:0046872 0 0 0 PF00147; Q9VY86 CHOYP_ISCW_ISCW014721.1.1 m.7228 sp TM2D2_DROME 59.333 150 61 0 35 184 74 223 7.61E-67 206 TM2D2_DROME reviewed TM2 domain-containing protein CG11103 CG11103 Drosophila melanogaster (Fruit fly) 224 0 GO:0016021 0 0 0 PF05154; A0JPN4 CHOYP_LOC100080726.1.1 m.59048 sp ZC12A_RAT 59.627 161 65 0 616 776 134 294 7.62E-60 218 ZC12A_RAT reviewed Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A) Zc3h12a Rattus norvegicus (Rat) 596 "3'-UTR-mediated mRNA destabilization [GO:0061158]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to tumor necrosis factor [GO:0071356]; immune system process [GO:0002376]; inflammatory response [GO:0006954]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma secretion [GO:1902714]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799]; negative regulation of tumor necrosis factor secretion [GO:1904468]; nervous system development [GO:0007399]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of cell death [GO:0010942]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein oligomerization [GO:0051259]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]" GO:0000932; GO:0001525; GO:0002376; GO:0003677; GO:0003682; GO:0003729; GO:0003730; GO:0004521; GO:0004532; GO:0005634; GO:0005654; GO:0005737; GO:0005791; GO:0005856; GO:0005886; GO:0006915; GO:0006954; GO:0006974; GO:0007399; GO:0010508; GO:0010595; GO:0010656; GO:0010884; GO:0010942; GO:0030154; GO:0030867; GO:0032088; GO:0035198; GO:0035613; GO:0035925; GO:0036459; GO:0042347; GO:0042406; GO:0043124; GO:0043234; GO:0045019; GO:0045600; GO:0045766; GO:0045944; GO:0046872; GO:0050713; GO:0051259; GO:0055118; GO:0061014; GO:0061158; GO:0071222; GO:0071356; GO:0090501; GO:0090502; GO:1900016; GO:1900165; GO:1902714; GO:1903003; GO:1903799; GO:1904468; GO:1904628; GO:1904637; GO:1990869; GO:2000379; GO:2000627 0 0 0 PF11977; A6NKF1 CHOYP_LOC101157769.1.1 m.16149 sp SAC31_HUMAN 33.546 313 200 4 9 317 54 362 7.62E-37 143 SAC31_HUMAN reviewed SAC3 domain-containing protein 1 (SAC3 homology domain-containing protein 1) SAC3D1 SHD1 Homo sapiens (Human) 404 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0005737; GO:0005815; GO:0005819; GO:0007067; GO:0051301 0 0 0 PF03399; P32241 CHOYP_SCTR.1.1 m.952 sp VIPR1_HUMAN 53.947 76 31 2 27 102 338 409 7.62E-18 83.6 VIPR1_HUMAN reviewed Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1) VIPR1 Homo sapiens (Human) 457 "cell surface receptor signaling pathway [GO:0007166]; chemical synaptic transmission [GO:0007268]; digestion [GO:0007586]; G-protein coupled receptor signaling pathway [GO:0007186]; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; muscle contraction [GO:0006936]; positive regulation of cell proliferation [GO:0008284]" GO:0004999; GO:0005886; GO:0005887; GO:0006936; GO:0006955; GO:0007166; GO:0007186; GO:0007187; GO:0007268; GO:0007586; GO:0008284; GO:0043235 0 0 0 PF00002;PF02793; Q14151 CHOYP_SAFB2.3.3 m.33384 sp SAFB2_HUMAN 45.378 119 60 2 327 445 408 521 7.62E-22 106 SAFB2_HUMAN reviewed Scaffold attachment factor B2 (SAF-B2) SAFB2 KIAA0138 Homo sapiens (Human) 953 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0042802; GO:0043231; GO:0044822; GO:0070062 0 0 0 PF00076;PF02037; Q32N66 CHOYP_LOC752321.1.1 m.15331 sp PARI_XENLA 28.539 438 239 12 80 499 25 406 7.62E-34 140 PARI_XENLA reviewed PCNA-interacting partner (PARI) (PARP-1 binding protein) (PARP1-binding protein) (PARPBP) parpbp pari Xenopus laevis (African clawed frog) 567 DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042] GO:0000785; GO:0003677; GO:0005634; GO:0005737; GO:0006281; GO:2000042 0 0 0 0 Q6P3Z3 CHOYP_NEMVEDRAFT_V1G162114.1.2 m.7613 sp THAP4_MOUSE 42.857 63 34 2 52 113 1 62 7.62E-09 60.5 THAP4_MOUSE reviewed THAP domain-containing protein 4 Thap4 Mus musculus (Mouse) 569 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q96MM6 CHOYP_BRAFLDRAFT_57788.5.10 m.36020 sp HS12B_HUMAN 31.21 628 362 17 18 579 61 684 7.62E-96 310 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9NRA2 CHOYP_LOC100367078.1.1 m.4441 sp S17A5_HUMAN 50 492 228 8 16 495 2 487 7.62E-162 472 S17A5_HUMAN reviewed Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) 495 amino acid transport [GO:0006865]; anion transport [GO:0006820]; ion transport [GO:0006811]; sialic acid transport [GO:0015739] GO:0005351; GO:0005737; GO:0005765; GO:0005886; GO:0005887; GO:0006811; GO:0006820; GO:0006865; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0030054; GO:0030672 0 0 cd06174; PF07690; Q9VCA8 CHOYP_LOC100637968.1.12 m.3178 sp ANKHM_DROME 31.72 372 224 16 205 558 622 981 7.62E-30 129 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; Q9VEN1 CHOYP_FLNA.3.6 m.22790 sp FLNA_DROME 40.441 136 80 1 11 145 1381 1516 7.62E-30 117 FLNA_DROME reviewed Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Filamin-1) (Filamin1) cher cheerio sko CG3937 Drosophila melanogaster (Fruit fly) 2210 "behavioral response to ethanol [GO:0048149]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; determination of adult lifespan [GO:0008340]; female germline ring canal formation [GO:0007301]; female germline ring canal formation, actin assembly [GO:0008302]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germline ring canal formation [GO:0030725]; learning or memory [GO:0007611]; mitotic nuclear division [GO:0007067]; motor neuron axon guidance [GO:0008045]; negative regulation of lamellocyte differentiation [GO:0035204]; olfactory learning [GO:0008355]; positive regulation of cytoskeleton organization [GO:0051495]; protein localization [GO:0008104]; sleep [GO:0030431]" GO:0003779; GO:0005829; GO:0005886; GO:0007067; GO:0007301; GO:0007303; GO:0007611; GO:0008045; GO:0008104; GO:0008302; GO:0008340; GO:0008355; GO:0015629; GO:0030431; GO:0030708; GO:0030725; GO:0035182; GO:0035183; GO:0035204; GO:0035324; GO:0045179; GO:0048149; GO:0051495 0 0 0 PF00307;PF00630; Q9W735 CHOYP_LOC100914852.1.1 m.29079 sp PRM1A_DANRE 27.95 805 529 17 46 819 34 818 7.62E-104 343 PRM1A_DANRE reviewed Prominin-1-A (Prominin-like protein 1) prom1a proml1 Danio rerio (Zebrafish) (Brachydanio rerio) 826 0 GO:0005783; GO:0005793; GO:0005886; GO:0016021; GO:0016324; GO:0031528 0 0 0 PF05478; Q9Y251 CHOYP_LOC100545679.1.1 m.54082 sp HPSE_HUMAN 37.328 509 279 14 34 511 37 536 7.62E-90 288 HPSE_HUMAN reviewed Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] HPSE HEP HPA HPA1 HPR1 HPSE1 HSE1 Homo sapiens (Human) 543 angiogenesis involved in wound healing [GO:0060055]; carbohydrate metabolic process [GO:0005975]; cell-matrix adhesion [GO:0007160]; extracellular matrix organization [GO:0030198]; glycosaminoglycan catabolic process [GO:0006027]; heparan sulfate proteoglycan catabolic process [GO:0030200]; positive regulation of blood coagulation [GO:0030194]; positive regulation of hair follicle development [GO:0051798]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of vascular endothelial growth factor production [GO:0010575]; proteoglycan metabolic process [GO:0006029]; regulation of hair follicle development [GO:0051797]; vascular wound healing [GO:0061042] GO:0004566; GO:0005578; GO:0005634; GO:0005654; GO:0005764; GO:0005765; GO:0005975; GO:0006027; GO:0006029; GO:0007160; GO:0010575; GO:0030194; GO:0030198; GO:0030200; GO:0030305; GO:0033690; GO:0043202; GO:0043231; GO:0043395; GO:0045121; GO:0045545; GO:0046983; GO:0051797; GO:0051798; GO:0051897; GO:0060055; GO:0061042 0 0 0 PF03662; A8DZE7 CHOYP_SDR42E1.1.1 m.43997 sp D42E1_DANRE 55.147 136 61 0 14 149 7 142 7.63E-48 161 D42E1_DANRE reviewed Short-chain dehydrogenase/reductase family 42E member 1 (EC 1.1.1.-) sdr42e1 si:ch211-79l17.4 zgc:123280 Danio rerio (Zebrafish) (Brachydanio rerio) 387 steroid biosynthetic process [GO:0006694] GO:0003854; GO:0006694; GO:0016021 0 0 0 PF01073; O15553 CHOYP_BRAFLDRAFT_82426.8.20 m.39042 sp MEFV_HUMAN 22.222 162 100 4 5 163 373 511 7.63E-08 57.8 MEFV_HUMAN reviewed Pyrin (Marenostrin) MEFV MEF TRIM20 Homo sapiens (Human) 781 inflammatory response [GO:0006954]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641]; negative regulation of NLRP3 inflammasome complex assembly [GO:1900226]; positive regulation of autophagy [GO:0010508]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; response to interferon-gamma [GO:0034341] GO:0001726; GO:0003779; GO:0005634; GO:0005737; GO:0005776; GO:0005829; GO:0005874; GO:0005875; GO:0006954; GO:0008270; GO:0010508; GO:0030027; GO:0031410; GO:0032691; GO:0032695; GO:0034341; GO:0050728; GO:0071641; GO:1900016; GO:1900226; GO:2001056 0 0 0 PF13765;PF02758;PF00622;PF00643; O43247 CHOYP_BRAFLDRAFT_117365.1.2 m.12413 sp TEX33_HUMAN 30.189 159 97 5 145 294 111 264 7.63E-11 65.9 TEX33_HUMAN reviewed Testis-expressed sequence 33 protein TEX33 C22orf33 EAN57 Homo sapiens (Human) 280 0 0 0 0 0 PF15400; P42577 CHOYP_LOC100371268.2.2 m.42523 sp FRIS_LYMST 87.324 142 18 0 1 142 1 142 7.63E-89 259 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; Q09638 CHOYP_NPR15.1.2 m.36065 sp NPR15_CAEEL 35.065 308 188 3 61 357 12 318 7.63E-53 182 NPR15_CAEEL reviewed Neuropeptide receptor 15 npr-15 T27D1.3 Caenorhabditis elegans 345 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q1ZXD6 CHOYP_BRAFLDRAFT_129004.7.15 m.35586 sp ROCO5_DICDI 36.082 97 39 5 243 336 1334 1410 7.63E-08 58.5 ROCO5_DICDI reviewed Probable serine/threonine-protein kinase roco5 (EC 2.7.11.1) (Ras of complex proteins and C-terminal of roc 5) roco5 DDB_G0294533 Dictyostelium discoideum (Slime mold) 2800 regulation of Rho protein signal transduction [GO:0035023]; small GTPase mediated signal transduction [GO:0007264]; sorocarp development [GO:0030587] GO:0004674; GO:0005089; GO:0005524; GO:0005525; GO:0005622; GO:0007264; GO:0030587; GO:0035023 0 0 0 PF16095;PF13516;PF13855;PF07714;PF00621;PF08477; Q61098 CHOYP_BRAFLDRAFT_244314.1.1 m.63591 sp IL18R_MOUSE 37.805 82 44 4 35 109 366 447 7.63E-06 48.5 IL18R_MOUSE reviewed Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (CD218 antigen-like family member A) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (CD antigen CD218a) Il18r1 Mus musculus (Mouse) 537 interleukin-18-mediated signaling pathway [GO:0035655]; natural killer cell activation [GO:0030101]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; T-helper 1 cell differentiation [GO:0045063] GO:0016021; GO:0030101; GO:0032729; GO:0035655; GO:0042008; GO:0042346; GO:0045063 0 0 0 PF13895;PF01582; Q80ZE5 CHOYP_MPRB.1.1 m.11332 sp MPRB_MOUSE 36.061 330 200 7 14 334 26 353 7.63E-48 167 MPRB_MOUSE reviewed Membrane progestin receptor beta (mPR beta) (Progestin and adipoQ receptor family member VIII) Paqr8 Mprb Mus musculus (Mouse) 354 multicellular organism development [GO:0007275]; oogenesis [GO:0048477]; response to steroid hormone [GO:0048545] GO:0003707; GO:0005496; GO:0005886; GO:0007275; GO:0016021; GO:0048477; GO:0048545 0 0 0 PF03006; Q8BHH9 CHOYP_GEPH.1.2 m.49094 sp T179A_MOUSE 29.897 97 61 2 28 124 111 200 7.63E-06 47.4 T179A_MOUSE reviewed Transmembrane protein 179 Tmem179 Mus musculus (Mouse) 233 0 GO:0016021 0 0 0 0 Q8R314 CHOYP_LOC100875839.1.1 m.63344 sp S35F5_MOUSE 53.017 464 192 9 6 452 62 516 7.63E-164 475 S35F5_MOUSE reviewed Solute carrier family 35 member F5 Slc35f5 Mus musculus (Mouse) 524 transport [GO:0006810] GO:0006810; GO:0016021 0 0 0 PF00892; Q91660 CHOYP_GLI3.1.1 m.34760 sp GLI3_XENLA 36.759 1080 516 46 93 1088 103 1099 7.63E-124 427 GLI3_XENLA reviewed Zinc finger protein GLI3 (Neural-specific DNA-binding protein xGLI3) (xGLI-3) gli3 Xenopus laevis (African clawed frog) 1569 "anterior/posterior pattern specification [GO:0009952]; dorsal/ventral pattern formation [GO:0009953]; embryonic organ development [GO:0048568]; positive regulation of transcription, DNA-templated [GO:0045893]; smoothened signaling pathway [GO:0007224]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0007224; GO:0009952; GO:0009953; GO:0045893; GO:0046872; GO:0048568 0 0 0 0 F6ZQ54 CHOYP_LOC100121684.1.3 m.39446 sp TRI13_XENTR 21.512 172 123 4 63 230 92 255 7.64E-06 50.4 TRI13_XENTR reviewed Tripartite motif containing 13 trim13 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 408 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; O15439 CHOYP_LOC662211.1.1 m.23379 sp MRP4_HUMAN 43.016 630 315 4 27 652 689 1278 7.64E-166 513 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O96006 CHOYP_ZBED1.2.2 m.47743 sp ZBED1_HUMAN 29.091 385 239 11 1 380 292 647 7.64E-39 150 ZBED1_HUMAN reviewed Zinc finger BED domain-containing protein 1 (Putative Ac-like transposable element) (dREF homolog) ZBED1 ALTE DREF KIAA0785 TRAMP Homo sapiens (Human) 694 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000228; GO:0000977; GO:0003700; GO:0004803; GO:0005634; GO:0005737; GO:0006357; GO:0015629; GO:0046872 0 0 0 PF05699;PF02892; P07589 CHOYP_LOC577931.2.3 m.13393 sp FINC_BOVIN 26.149 348 196 15 374 709 1773 2071 7.64E-12 75.1 FINC_BOVIN reviewed Fibronectin (FN) [Cleaved into: Anastellin] FN1 Bos taurus (Bovine) 2478 acute-phase response [GO:0006953]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; regulation of cell shape [GO:0008360] GO:0001525; GO:0005576; GO:0005578; GO:0006953; GO:0007155; GO:0008201; GO:0008360 0 0 cd00062; PF00039;PF00040;PF00041; P22105 CHOYP_LOAG_10561.1.1 m.50948 sp TENX_HUMAN 25.103 243 106 10 32 268 197 369 7.64E-10 65.1 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P9WK87 CHOYP_LOC100371983.2.3 m.48879 sp NLHH_MYCTU 33.878 245 149 6 60 295 54 294 7.64E-33 126 NLHH_MYCTU reviewed Carboxylesterase NlhH (EC 3.1.1.1) nlhH lipH Rv1399c Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 319 catabolic process [GO:0009056] GO:0009056; GO:0034338 0 0 0 PF07859; Q02763 CHOYP_TIE2.6.6 m.66015 sp TIE2_HUMAN 27.443 481 297 14 887 1341 642 1096 7.64E-45 181 TIE2_HUMAN reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b) TEK TIE2 VMCM VMCM1 Homo sapiens (Human) 1124 angiogenesis [GO:0001525]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; leukocyte migration [GO:0050900]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; organ regeneration [GO:0031100]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0000165; GO:0001525; GO:0001666; GO:0001934; GO:0001935; GO:0001938; GO:0001958; GO:0002040; GO:0004672; GO:0004713; GO:0004714; GO:0004872; GO:0005088; GO:0005524; GO:0005576; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007165; GO:0007169; GO:0007267; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016323; GO:0016324; GO:0016525; GO:0018108; GO:0031100; GO:0032878; GO:0034446; GO:0043066; GO:0043114; GO:0043434; GO:0043552; GO:0043627; GO:0045121; GO:0045766; GO:0046777; GO:0048014; GO:0050728; GO:0050900; GO:0051259; GO:0051591; GO:0051894; GO:0051897; GO:0060216; GO:0060347; GO:0070374; GO:0072012; GO:1902533; GO:2000251; GO:2000351; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q3U4G3 CHOYP_C3ORF21.2.2 m.65712 sp XXLT1_MOUSE 44.771 306 152 5 13 302 86 390 7.64E-99 299 XXLT1_MOUSE reviewed "Xyloside xylosyltransferase 1 (EC 2.4.2.n3) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)" Xxylt1 Mus musculus (Mouse) 392 0 GO:0005789; GO:0016021; GO:0016763 0 0 0 PF01501; Q61847 CHOYP_MEP1B.4.4 m.46125 sp MEP1B_MOUSE 27.195 353 210 19 84 414 104 431 7.64E-18 89.4 MEP1B_MOUSE reviewed Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) Mep1b Mep-1b Mus musculus (Mouse) 704 inflammatory response [GO:0006954]; toxin transport [GO:1901998] GO:0004222; GO:0005576; GO:0005886; GO:0006954; GO:0008270; GO:0016020; GO:0016021; GO:1901998 0 0 cd06263; PF01400;PF00008;PF00629; Q6DJM2 CHOYP_TAM41.1.1 m.14077 sp TAM41_XENLA 51.572 318 153 1 38 355 16 332 7.64E-112 332 TAM41_XENLA reviewed "Phosphatidate cytidylyltransferase, mitochondrial (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (Mitochondrial translocator assembly and maintenance protein 41 homolog) (TAM41)" tamm41 Xenopus laevis (African clawed frog) 338 cardiolipin biosynthetic process [GO:0032049]; CDP-diacylglycerol biosynthetic process [GO:0016024] GO:0004605; GO:0016024; GO:0031314; GO:0032049 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3. 0 0 PF09139; Q8K4Y7 CHOYP_LOC100563392.1.1 m.8300 sp CANT1_RAT 56.289 318 138 1 74 391 87 403 7.64E-128 376 CANT1_RAT reviewed Soluble calcium-activated nucleotidase 1 (SCAN-1) (EC 3.6.1.6) (Apyrase homolog) Cant1 Srapy Rattus norvegicus (Rat) 403 positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; proteoglycan biosynthetic process [GO:0030166] GO:0004382; GO:0004871; GO:0005509; GO:0005789; GO:0016021; GO:0030166; GO:0032580; GO:0043123; GO:0045134; GO:0070062 0 0 0 PF06079; Q96GP6 CHOYP_PTPRC.14.14 m.62304 sp SREC2_HUMAN 38.655 119 68 5 212 330 245 358 7.64E-13 72.8 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9CZJ2 CHOYP_BRAFLDRAFT_208436.15.32 m.50355 sp HS12B_MOUSE 30.655 336 178 9 55 340 61 391 7.64E-42 157 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 B3EWY9 CHOYP_LOC590125.7.7 m.65882 sp MLP_ACRMI 27.7 1065 616 40 451 1449 387 1363 7.65E-92 335 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; B4KMZ1 CHOYP_BRAFLDRAFT_109205.2.5 m.19804 sp LPHN_DROMO 36.709 79 46 2 1 79 46 120 7.65E-11 61.6 LPHN_DROMO reviewed Latrophilin Cirl Cirl GI18798 Drosophila mojavensis (Fruit fly) 1725 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0005886; GO:0007166; GO:0016021; GO:0030246 0 0 0 PF16489;PF02140;PF01825; D3ZTX0 CHOYP_TMED7.1.3 m.6189 sp TMED7_RAT 62.5 192 71 1 20 211 36 226 7.65E-88 261 TMED7_RAT reviewed Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27) Tmed7 Rattus norvegicus (Rat) 226 protein transport [GO:0015031] GO:0005783; GO:0005789; GO:0005793; GO:0005794; GO:0012507; GO:0015031; GO:0016021; GO:0030663; GO:0033116; GO:0070062 0 0 0 PF01105; P27393 CHOYP_COPA1.2.2 m.66805 sp CO4A2_ASCSU 48.79 248 94 7 117 341 1064 1301 7.65E-30 129 CO4A2_ASCSU reviewed Collagen alpha-2(IV) chain 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 1763 0 GO:0005201; GO:0005581; GO:0005604 0 0 0 PF01413;PF01391; Q502M6 CHOYP_TVAG_470020.2.8 m.20057 sp ANR29_DANRE 43.396 106 60 0 1 106 64 169 7.65E-20 84.7 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5RF32 CHOYP_LOC100371248.1.2 m.10238 sp BHMT2_PONAB 34.161 322 185 8 20 331 12 316 7.65E-48 169 BHMT2_PONAB reviewed S-methylmethionine--homocysteine S-methyltransferase BHMT2 (SMM-hcy methyltransferase) (EC 2.1.1.10) (Betaine--homocysteine S-methyltransferase 2) BHMT2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 363 methionine biosynthetic process [GO:0009086] GO:0005737; GO:0008270; GO:0009086; GO:0047150 PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. 0 0 PF02574; Q5ZL33 CHOYP_LOC100118098.1.1 m.14795 sp STRAP_CHICK 68.285 309 96 2 35 343 2 308 7.65E-147 421 STRAP_CHICK reviewed Serine-threonine kinase receptor-associated protein STRAP RCJMB04_7p19 Gallus gallus (Chicken) 350 maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; spliceosomal snRNP assembly [GO:0000387] GO:0000122; GO:0000387; GO:0005102; GO:0005634; GO:0005829; GO:0010633; GO:0010719; GO:0030277; GO:0030512; GO:0032797; GO:0034719; GO:0044822; GO:0050680; GO:0060394 0 0 0 PF00400; Q6MHJ5 CHOYP_LOC100890415.2.2 m.65641 sp PIF1_BDEBA 46.377 69 34 1 2 70 365 430 7.65E-10 62.8 PIF1_BDEBA reviewed ATP-dependent DNA helicase pif1 (EC 3.6.4.12) pif1 Bd3546 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) 439 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; telomere maintenance [GO:0000723] GO:0000723; GO:0003677; GO:0003678; GO:0005524; GO:0006281; GO:0006310 0 0 0 PF05970; Q8IXZ2 CHOYP_LOC101168697.1.2 m.3923 sp ZC3H3_HUMAN 59.146 164 64 2 633 793 644 807 7.65E-62 229 ZC3H3_HUMAN reviewed Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) ZC3H3 KIAA0150 SMICL ZC3HDC3 Homo sapiens (Human) 948 mRNA polyadenylation [GO:0006378]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of activin receptor signaling pathway [GO:0032927]; regulation of mRNA export from nucleus [GO:0010793] GO:0003677; GO:0005634; GO:0005847; GO:0006378; GO:0010793; GO:0016973; GO:0032927; GO:0046872 0 0 0 PF00642; Q8R035 CHOYP_AGAP_AGAP008425.1.1 m.9212 sp ICT1_MOUSE 42.775 173 91 2 40 211 37 202 7.65E-39 135 ICT1_MOUSE reviewed "Peptidyl-tRNA hydrolase ICT1, mitochondrial (EC 3.1.1.29) (39S ribosomal protein L58, mitochondrial) (MRP-L58) (Immature colon carcinoma transcript 1 protein homolog)" Ict1 Mrpl58 Mus musculus (Mouse) 206 mitochondrial translational termination [GO:0070126]; rescue of stalled ribosome [GO:0072344] GO:0004045; GO:0005739; GO:0005762; GO:0016150; GO:0043022; GO:0070126; GO:0072344 0 0 0 PF00472; Q8TEJ3 CHOYP_F16A2.3.3 m.62954 sp SH3R3_HUMAN 35.996 889 413 29 1 785 46 882 7.65E-139 435 SH3R3_HUMAN reviewed SH3 domain-containing RING finger protein 3 (Plenty of SH3s 2) (SH3 multiple domains protein 4) SH3RF3 POSH2 SH3MD4 Homo sapiens (Human) 882 0 GO:0008270 0 0 0 PF00018;PF14604; Q920N2 CHOYP_CP2CN.1.1 m.20210 sp BPL1_MOUSE 48.739 357 178 5 1 354 363 717 7.65E-117 357 BPL1_MOUSE reviewed Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin--[methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin--[acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)] Hlcs Mus musculus (Mouse) 722 cell proliferation [GO:0008283]; histone biotinylation [GO:0071110]; histone modification [GO:0016570]; protein biotinylation [GO:0009305]; response to biotin [GO:0070781] GO:0000785; GO:0004077; GO:0004078; GO:0004079; GO:0004080; GO:0005524; GO:0005652; GO:0005737; GO:0005739; GO:0005829; GO:0008283; GO:0009305; GO:0009374; GO:0016363; GO:0016570; GO:0018271; GO:0019899; GO:0042803; GO:0070781; GO:0071110 0 0 0 PF02237;PF03099;PF09825; Q9HCF6 CHOYP_TRPM3.3.7 m.16169 sp TRPM3_HUMAN 30.415 1302 750 32 300 1552 106 1300 7.65E-172 566 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9W6B3 CHOYP_RARB.2.3 m.19588 sp RARB_COTJA 56.393 305 107 3 78 374 83 369 7.65E-116 349 RARB_COTJA reviewed Retinoic acid receptor beta (RAR-beta) (Nuclear receptor subfamily 1 group B member 2) RARB NR1B2 Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 455 "transcription, DNA-templated [GO:0006351]" GO:0003707; GO:0003708; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; A0JNA8 CHOYP_PAXI1.1.4 m.340 sp PAXI1_BOVIN 40.919 479 278 4 333 807 507 984 7.66E-124 399 PAXI1_BOVIN reviewed PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) PAXIP1 Bos taurus (Bovine) 984 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0016363 0 0 0 PF00533;PF12738;PF16770; A4IF63 CHOYP_BRAFLDRAFT_88224.9.11 m.47701 sp TRIM2_BOVIN 27.982 218 143 4 383 596 536 743 7.66E-16 84.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O60462 CHOYP_NRP1.4.5 m.47250 sp NRP2_HUMAN 26.765 340 214 14 56 379 45 365 7.66E-20 96.3 NRP2_HUMAN reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) NRP2 VEGF165R2 Homo sapiens (Human) 931 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; nerve development [GO:0021675]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0001938; GO:0002116; GO:0004872; GO:0005021; GO:0005576; GO:0005886; GO:0007155; GO:0007411; GO:0008201; GO:0010595; GO:0016020; GO:0016021; GO:0017154; GO:0019838; GO:0019955; GO:0021675; GO:0046872; GO:0048010; GO:0048846; GO:0061549; GO:0097490; GO:0097491; GO:1902285 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; Q06852 CHOYP_LOC100535301.1.5 m.3176 sp SLAP1_CLOTH 56.941 353 91 28 390 688 1426 1771 7.66E-23 108 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q08699 CHOYP_LOC549476.1.1 m.42389 sp RS14_PODCA 84.507 71 10 1 11 80 1 71 7.66E-37 126 RS14_PODCA reviewed 40S ribosomal protein S14 RPS14 Podocoryna carnea (Jellyfish) 151 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00411; Q10651 CHOYP_A4.1.3 m.3377 sp A4_CAEEL 32.813 448 271 12 4 425 1 444 7.66E-66 231 A4_CAEEL reviewed Beta-amyloid-like protein apl-1 C42D8.8 Caenorhabditis elegans 686 "body morphogenesis [GO:0010171]; cell differentiation [GO:0030154]; ecdysis, collagen and cuticulin-based cuticle [GO:0042395]; nematode larval development [GO:0002119]; nervous system development [GO:0007399]" GO:0002119; GO:0005769; GO:0007399; GO:0008201; GO:0010171; GO:0016021; GO:0030154; GO:0031410; GO:0042395; GO:0043005; GO:0043025; GO:0046914 0 0 0 PF10515;PF12924;PF12925;PF02177; Q4KLI9 CHOYP_ISCW_ISCW008293.4.5 m.54565 sp FBXW5_RAT 27.052 536 315 19 2 487 42 551 7.66E-41 157 FBXW5_RAT reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Rattus norvegicus (Rat) 569 centrosome duplication [GO:0051298]; mitotic nuclear division [GO:0007067]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0000151; GO:0005737; GO:0007067; GO:0010824; GO:0016567; GO:0019005; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q58EK4 CHOYP_LOC100373656.1.1 m.57145 sp PARL_DANRE 42.647 68 39 0 136 203 173 240 7.66E-10 60.8 PARL_DANRE reviewed "Presenilins-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105)" parl zgc:112986 Danio rerio (Zebrafish) (Brachydanio rerio) 383 protein processing [GO:0016485] GO:0004252; GO:0005743; GO:0016021; GO:0016485 0 0 0 PF01694; Q5ND28 CHOYP_CED1.20.29 m.45054 sp SREC_MOUSE 28.571 196 93 9 4 154 212 405 7.66E-07 55.1 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q7Z3B1 CHOYP_LOC663761.1.1 m.26827 sp NEGR1_HUMAN 36.458 192 109 6 12 201 47 227 7.66E-25 102 NEGR1_HUMAN reviewed Neuronal growth regulator 1 (IgLON family member 4) NEGR1 IGLON4 UNQ2433/PRO4993 Homo sapiens (Human) 354 feeding behavior [GO:0007631]; locomotory behavior [GO:0007626]; positive regulation of neuron projection development [GO:0010976]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007626; GO:0007631; GO:0010976; GO:0016337; GO:0031225; GO:0070062 0 0 0 PF07679; Q895K2 CHOYP_LOC100377759.12.15 m.50953 sp DPO3_CLOTE 29.255 188 109 8 74 257 410 577 7.66E-08 56.6 DPO3_CLOTE reviewed DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC CTC_01271 Clostridium tetani (strain Massachusetts / E88) 1427 DNA-dependent DNA replication [GO:0006261] GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 0 0 0 PF11490;PF07733;PF14579;PF02811;PF00929;PF01336; Q8BH66 CHOYP_BRAFLDRAFT_246994.1.1 m.36305 sp ATLA1_MOUSE 36.066 183 113 2 1 183 193 371 7.66E-37 138 ATLA1_MOUSE reviewed Atlastin-1 (EC 3.6.5.-) (Spastic paraplegia 3A homolog) Atl1 Spg3a Mus musculus (Mouse) 558 axonogenesis [GO:0007409]; endoplasmic reticulum organization [GO:0007029]; protein homooligomerization [GO:0051260] GO:0000137; GO:0000139; GO:0003924; GO:0005525; GO:0005737; GO:0005783; GO:0005789; GO:0005794; GO:0007029; GO:0007409; GO:0016021; GO:0030424; GO:0042802; GO:0051260 0 0 0 PF02263; Q99PP7 CHOYP_BRAFLDRAFT_82869.5.6 m.62272 sp TRI33_MOUSE 25.472 212 136 5 2 208 221 415 7.66E-11 66.2 TRI33_MOUSE reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) Trim33 Kiaa1113 Mus musculus (Mouse) 1142 "negative regulation of BMP signaling pathway [GO:0030514]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q9Y6Y1 CHOYP_CAMTA1.1.1 m.54104 sp CMTA1_HUMAN 54.206 214 92 4 12 219 40 253 7.66E-65 246 CMTA1_HUMAN reviewed Calmodulin-binding transcription activator 1 CAMTA1 KIAA0833 MSTP023 Homo sapiens (Human) 1673 neuromuscular process controlling balance [GO:0050885]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0001077; GO:0005634; GO:0005737; GO:0043565; GO:0045944; GO:0050885 0 0 0 PF03859;PF00612;PF01833; A7S8T5 CHOYP_CCD42.1.1 m.35832 sp CCD42_NEMVE 70.567 282 83 0 1 282 1 282 7.67E-137 394 CCD42_NEMVE reviewed Coiled-coil domain-containing protein 42 homolog v1g187067 Nematostella vectensis (Starlet sea anemone) 312 0 0 0 0 0 PF13863; B0JZG0 CHOYP_LOC100376056.2.2 m.62565 sp S23A2_XENTR 46.029 554 282 5 58 610 90 627 7.67E-172 506 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; D2H8V8 CHOYP_LOC100372601.1.1 m.13567 sp DCR1B_AILME 41.99 412 206 8 1 408 1 383 7.67E-97 309 DCR1B_AILME reviewed 5' exonuclease Apollo (EC 3.1.-.-) (DNA cross-link repair 1B protein) (SNM1 homolog B) DCLRE1B SNM1B PANDA_006715 Ailuropoda melanoleuca (Giant panda) 529 cell cycle checkpoint [GO:0000075]; DNA repair [GO:0006281]; protection from non-homologous end joining at telomere [GO:0031848]; telomere maintenance [GO:0000723]; telomeric 3' overhang formation [GO:0031860]; telomeric loop formation [GO:0031627] GO:0000075; GO:0000723; GO:0000781; GO:0005634; GO:0005737; GO:0005813; GO:0006281; GO:0008409; GO:0031627; GO:0031848; GO:0031860 0 0 0 PF07522; O15151 CHOYP_LOC100770120.1.1 m.27219 sp MDM4_HUMAN 31.25 272 141 9 311 540 222 489 7.67E-26 114 MDM4_HUMAN reviewed Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) MDM4 MDMX Homo sapiens (Human) 490 "cell proliferation [GO:0008283]; cellular response to hypoxia [GO:0071456]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G0 to G1 transition [GO:0045023]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]" GO:0000122; GO:0005634; GO:0005654; GO:0006461; GO:0006977; GO:0008270; GO:0008283; GO:0008285; GO:0019899; GO:0030330; GO:0042177; GO:0043066; GO:0045023; GO:0050821; GO:0061630; GO:0071157; GO:0071456; GO:1901796 0 0 0 PF02201;PF00641; O15439 CHOYP_LOC100702162.1.1 m.30343 sp MRP4_HUMAN 38.562 612 327 5 7 592 164 752 7.67E-141 446 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; O35623 CHOYP_BRAFLDRAFT_125614.1.1 m.62912 sp BET1_MOUSE 46.61 118 55 1 1 110 1 118 7.67E-30 106 BET1_MOUSE reviewed BET1 homolog (mBET1) (Golgi vesicular membrane-trafficking protein p18) Bet1 Mus musculus (Mouse) 118 ER to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle-mediated transport [GO:0016192] GO:0000139; GO:0005789; GO:0005801; GO:0006888; GO:0015031; GO:0016020; GO:0016021; GO:0016192; GO:0031201; GO:0031985; GO:0048280 0 0 0 0 P06605 CHOYP_ALPHATUB84D.1.1 m.16562 sp TBA3_DROME 96.899 129 4 0 13 141 45 173 7.67E-84 256 TBA3_DROME reviewed Tubulin alpha-3 chain alphaTub84D TubA84D CG2512 Drosophila melanogaster (Fruit fly) 450 microtubule-based process [GO:0007017]; mitotic cytokinesis [GO:0000281] GO:0000281; GO:0003924; GO:0005200; GO:0005525; GO:0005811; GO:0005874; GO:0007017; GO:0017022; GO:0048471 0 0 0 PF00091;PF03953; P24044 CHOYP_CML8.1.1 m.37436 sp CALM_PLAFA 29.197 137 93 1 107 243 12 144 7.67E-15 72.8 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; Q60787 CHOYP_LCP2.1.14 m.4968 sp LCP2_MOUSE 36.296 135 83 2 530 661 389 523 7.67E-19 94 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q66J97 CHOYP_RNF165B.1.2 m.30160 sp R111C_XENLA 47.179 195 66 5 29 205 786 961 7.67E-40 148 R111C_XENLA reviewed E3 ubiquitin-protein ligase arkadia-C (EC 6.3.2.-) (RING finger protein 111-C) rnf111-c Xenopus laevis (African clawed frog) 967 protein ubiquitination [GO:0016567] GO:0005634; GO:0005737; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15303;PF13639; Q7YW31 CHOYP_LOC661502.1.1 m.20873 sp CTR1_OCTVU 26.05 238 155 5 52 280 54 279 7.67E-15 79.3 CTR1_OCTVU reviewed Cephalotocin receptor 1 (OC/CE-R 1) (OT/VP superfamily peptide receptor 1) CTR1 Octopus vulgaris (Common octopus) 397 G-protein coupled receptor signaling pathway [GO:0007186] GO:0005000; GO:0005886; GO:0007186; GO:0016021; GO:0016500 0 0 0 PF00001; Q8VIK5 CHOYP_MEG10.22.91 m.28727 sp PEAR1_MOUSE 32.486 354 198 17 204 553 466 782 7.67E-27 119 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q99315 CHOYP_CRE_26779.1.2 m.9085 sp YG31B_YEAST 32.147 787 459 16 159 927 588 1317 7.67E-107 373 YG31B_YEAST reviewed Transposon Ty3-G Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-1 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p61 (IN); Integrase p58 (IN)] TY3B-G YGRWTy3-1 POL YGR109W-B G5984 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1547 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q9EQU5 CHOYP_LOC101067281.1.2 m.14665 sp SET_MOUSE 77.523 218 47 2 4 220 18 234 7.67E-117 340 SET_MOUSE reviewed Protein SET (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) Set Mus musculus (Mouse) 289 "negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome assembly [GO:0006334]" GO:0003677; GO:0005634; GO:0005654; GO:0005737; GO:0005783; GO:0005829; GO:0006334; GO:0043234; GO:0043524; GO:0045892; GO:0048471 0 0 0 PF00956; Q9NX07 CHOYP_TSAP1.1.2 m.36101 sp TSAP1_HUMAN 52 75 36 0 30 104 2 76 7.67E-24 97.4 TSAP1_HUMAN reviewed tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1) TRNAU1AP SECP43 TRSPAP1 Homo sapiens (Human) 287 selenocysteine incorporation [GO:0001514] GO:0000166; GO:0001514; GO:0005634; GO:0005737; GO:0044822 0 0 0 PF00076; Q9QXW9 CHOYP_LAT1.2.2 m.58598 sp LAT2_MOUSE 53.629 496 216 3 20 501 2 497 7.67E-178 513 LAT2_MOUSE reviewed Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (mLAT2) (Solute carrier family 7 member 8) Slc7a8 Lat2 Mus musculus (Mouse) 531 amino acid transport [GO:0006865]; L-amino acid transport [GO:0015807]; neutral amino acid transport [GO:0015804] GO:0005275; GO:0005737; GO:0005886; GO:0005887; GO:0006865; GO:0015101; GO:0015171; GO:0015175; GO:0015179; GO:0015297; GO:0015804; GO:0015807; GO:0016323; GO:0019534; GO:0070062 0 0 0 PF13520; A6H584 CHOYP_LOC100931725.1.1 m.22064 sp CO6A5_MOUSE 29.67 273 168 8 66 337 645 894 7.68E-22 102 CO6A5_MOUSE reviewed Collagen alpha-5(VI) chain (Collagen alpha-1(XXIX) chain) Col6a5 Col29a1 Gm7455 Mus musculus (Mouse) 2640 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; O88281 CHOYP_MEGF6.52.59 m.54262 sp MEGF6_RAT 31.414 955 552 42 137 1073 512 1381 7.68E-90 322 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; O95847 CHOYP_LOC580090.1.1 m.29441 sp UCP4_HUMAN 58.609 302 118 3 22 316 22 323 7.68E-129 373 UCP4_HUMAN reviewed Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27) SLC25A27 UCP4 UNQ772/PRO1566 Homo sapiens (Human) 323 generation of precursor metabolites and energy [GO:0006091]; proton transport [GO:0015992]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005743; GO:0006091; GO:0006412; GO:0015992; GO:0016021 0 0 0 PF00153; P16157 CHOYP_TVAG_020440.10.21 m.21068 sp ANK1_HUMAN 34.961 512 300 2 1 479 246 757 7.68E-81 277 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P25304 CHOYP_AGRIN.2.5 m.5339 sp AGRIN_RAT 27.857 280 143 11 23 267 91 346 7.68E-13 72.4 AGRIN_RAT reviewed Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment (C90); Agrin C-terminal 22 kDa fragment (C22)] Agrn Agrin Rattus norvegicus (Rat) 1959 chemical synaptic transmission [GO:0007268]; neuromuscular junction development [GO:0007528]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein heterotetramerization [GO:0051290]; receptor clustering [GO:0043113]; regulation of axon guidance [GO:1902667]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse assembly [GO:0007416] GO:0001932; GO:0001934; GO:0002162; GO:0005509; GO:0005576; GO:0005578; GO:0005604; GO:0005605; GO:0005886; GO:0007268; GO:0007416; GO:0007528; GO:0016021; GO:0030054; GO:0033691; GO:0035374; GO:0036122; GO:0043113; GO:0043395; GO:0043547; GO:0044295; GO:0045202; GO:0045887; GO:0045944; GO:0050431; GO:0050731; GO:0051290; GO:0051491; GO:0070507; GO:0071340; GO:1902667 0 0 0 PF00008;PF00050;PF07648;PF00053;PF00054;PF01390; Q6PFY8 CHOYP_LOC100367817.4.7 m.48246 sp TRI45_MOUSE 30.392 204 125 6 8 205 129 321 7.68E-14 77.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8C3Q9 CHOYP_CASP9.2.2 m.56967 sp CASP9_MOUSE 25.873 487 288 17 1 450 1 451 7.68E-23 103 CASP9_MOUSE reviewed Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10] Casp9 Mch6 Mus musculus (Mouse) 454 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aging [GO:0007568]; apoptotic process [GO:0006915]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; glial cell apoptotic process [GO:0034349]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of response to DNA damage stimulus [GO:2001020]; response to antibiotic [GO:0046677]; response to cobalt ion [GO:0032025]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]; response to UV [GO:0009411]; signal transduction in response to DNA damage [GO:0042770] GO:0004197; GO:0005634; GO:0005739; GO:0005829; GO:0006915; GO:0006919; GO:0006974; GO:0007568; GO:0008233; GO:0008630; GO:0009411; GO:0017124; GO:0019901; GO:0032025; GO:0032355; GO:0032496; GO:0034349; GO:0034644; GO:0042770; GO:0043293; GO:0043525; GO:0046677; GO:0070059; GO:0071549; GO:0097153; GO:2001020 0 0 0 PF00619; Q99933 CHOYP_BAG1.2.2 m.60616 sp BAG1_HUMAN 37.427 171 106 1 43 213 170 339 7.68E-30 116 BAG1_HUMAN reviewed BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) BAG1 HAP Homo sapiens (Human) 345 apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; chaperone cofactor-dependent protein refolding [GO:0070389]; negative regulation of apoptotic process [GO:0043066]; regulation of cellular response to heat [GO:1900034] GO:0000774; GO:0005057; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007166; GO:0043066; GO:0070389; GO:1900034 0 0 0 PF02179;PF00240; Q9NU22 CHOYP_MDN1.1.8 m.1490 sp MDN1_HUMAN 65.903 393 127 4 1 391 1111 1498 7.68E-174 541 MDN1_HUMAN reviewed Midasin (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) 5596 protein complex assembly [GO:0006461]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0006461; GO:0016020; GO:0016887; GO:0045111; GO:0051082 0 0 0 PF07728; B2RU80 CHOYP_PTP10.3.3 m.46720 sp PTPRB_MOUSE 30.855 807 469 30 635 1407 1228 1979 7.69E-87 317 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; P08045 CHOYP_BRAFLDRAFT_66688.1.2 m.2447 sp XFIN_XENLA 20.585 923 543 38 1290 2164 158 938 7.69E-10 68.9 XFIN_XENLA reviewed Zinc finger protein Xfin (Xenopus fingers protein) (Xfin) 0 Xenopus laevis (African clawed frog) 1350 "regulation of transcription, DNA-templated [GO:0006355]" GO:0003723; GO:0005737; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; P30883 CHOYP_LOC373275.2.7 m.14503 sp TBB4_XENLA 93.333 120 4 1 1 116 73 192 7.69E-63 200 TBB4_XENLA reviewed Tubulin beta-4 chain tubb4 Xenopus laevis (African clawed frog) 445 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P52800 CHOYP_DPER_GL18144.1.1 m.58700 sp EFNB2_MOUSE 30.729 192 116 7 40 224 36 217 7.69E-18 85.5 EFNB2_MOUSE reviewed Ephrin-B2 (ELF-2) (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) Efnb2 Elf2 Epl5 Eplg5 Htkl Lerk5 Mus musculus (Mouse) 336 axon guidance [GO:0007411]; blood vessel morphogenesis [GO:0048514]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; lymph vessel development [GO:0001945]; negative regulation of keratinocyte proliferation [GO:0010839]; nephric duct morphogenesis [GO:0072178]; organ morphogenesis [GO:0009887]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; regulation of chemotaxis [GO:0050920]; T cell costimulation [GO:0031295]; venous blood vessel morphogenesis [GO:0048845] GO:0001945; GO:0002042; GO:0005102; GO:0005886; GO:0005925; GO:0007155; GO:0007411; GO:0009887; GO:0010839; GO:0016021; GO:0016477; GO:0031295; GO:0046875; GO:0048013; GO:0048514; GO:0048845; GO:0050920; GO:0072178; GO:1903849; GO:2000727 0 0 0 PF00812; P59999 CHOYP_ARPC4.1.2 m.19496 sp ARPC4_MOUSE 80 150 30 0 15 164 1 150 7.69E-87 254 ARPC4_MOUSE reviewed Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) Arpc4 Arc20 Mus musculus (Mouse) 168 actin filament polymerization [GO:0030041]; Arp2/3 complex-mediated actin nucleation [GO:0034314] GO:0005200; GO:0005737; GO:0005885; GO:0019899; GO:0030041; GO:0034314; GO:0042995; GO:0070062 0 0 0 PF05856; Q14679 CHOYP_TTLL4.1.1 m.12923 sp TTLL4_HUMAN 34.872 195 89 4 475 660 469 634 7.69E-23 107 TTLL4_HUMAN reviewed Tubulin polyglutamylase TTLL4 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 4) TTLL4 KIAA0173 Homo sapiens (Human) 1199 peptidyl-glutamic acid modification [GO:0018200]; protein polyglutamylation [GO:0018095] GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0015631; GO:0018095; GO:0018200; GO:0070739 0 0 0 PF03133; Q9CZJ2 CHOYP_LOC100207121.3.9 m.38720 sp HS12B_MOUSE 29.276 649 373 21 958 1531 46 683 7.69E-70 252 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9ESN6 CHOYP_BRAFLDRAFT_69764.3.19 m.20496 sp TRIM2_MOUSE 23.137 255 146 9 141 348 492 743 7.69E-07 54.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P30974 CHOYP_contig_021859 m.25100 sp TLR1_DROME 26.074 326 202 10 25 345 80 371 7.70E-14 75.9 TLR1_DROME reviewed Tachykinin-like peptides receptor 86C (NKD) TkR86C NKD Takr86C CG6515 Drosophila melanogaster (Fruit fly) 504 G-protein coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217] GO:0002121; GO:0004995; GO:0005887; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016021 0 0 0 PF00001; Q0V9J0 CHOYP_LOC101061754.1.1 m.16240 sp TMM69_XENTR 39.175 194 94 8 81 257 48 234 7.70E-27 108 TMM69_XENTR reviewed Transmembrane protein 69 tmem69 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 253 0 GO:0016021 0 0 0 PF11911; Q3SX45 CHOYP_TVAG_272220.1.1 m.21385 sp ASB2_BOVIN 27.442 215 131 5 498 705 150 346 7.70E-13 75.5 ASB2_BOVIN reviewed Ankyrin repeat and SOCS box protein 2 (ASB-2) ASB2 Bos taurus (Bovine) 633 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q4UMH6 CHOYP_Y381.3.4 m.35974 sp Y381_RICFE 25.575 391 236 15 294 669 733 1083 7.70E-15 82.4 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q6NS23 CHOYP_TRM11.1.1 m.11729 sp TRM11_XENLA 45.011 451 236 6 12 455 3 448 7.70E-135 400 TRM11_XENLA reviewed tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) trmt11 Xenopus laevis (African clawed frog) 478 tRNA processing [GO:0008033] GO:0000049; GO:0008033; GO:0008168 0 0 0 PF01170; Q8C180 CHOYP_LOC662137.1.1 m.37517 sp FRS2_MOUSE 51.852 108 44 3 1 102 1 106 7.70E-28 117 FRS2_MOUSE reviewed Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (FRS2-alpha) (Suc1-associated neurotrophic factor target 1) (SNT-1) Frs2 Frs2a Mus musculus (Mouse) 508 "activation of MAPK activity [GO:0000187]; anterior/posterior axis specification, embryo [GO:0008595]; fibroblast growth factor receptor signaling pathway [GO:0008543]; forebrain development [GO:0030900]; gastrulation with mouth forming second [GO:0001702]; lens development in camera-type eye [GO:0002088]; lens fiber cell development [GO:0070307]; neuroblast proliferation [GO:0007405]; optic placode formation involved in camera-type eye formation [GO:0046619]; organ induction [GO:0001759]; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [GO:0060527]; regulation of apoptotic process [GO:0042981]; regulation of epithelial cell proliferation [GO:0050678]; regulation of ERK1 and ERK2 cascade [GO:0070372]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; ventricular septum development [GO:0003281]" GO:0000187; GO:0001702; GO:0001759; GO:0002088; GO:0003281; GO:0005068; GO:0005104; GO:0005168; GO:0005737; GO:0005886; GO:0005911; GO:0007169; GO:0007405; GO:0008543; GO:0008595; GO:0030900; GO:0042981; GO:0046619; GO:0050678; GO:0060527; GO:0070307; GO:0070372 0 0 0 PF02174; Q8C8H8 CHOYP_KY.5.5 m.60285 sp KY_MOUSE 35.294 153 81 6 846 988 228 372 7.70E-17 89.4 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q8WPA2 CHOYP_AR.1.1 m.38655 sp AR_BOMMO 44.568 359 180 6 18 369 10 356 7.70E-91 281 AR_BOMMO reviewed Allatostatin-A receptor (BAR) AR Bombyx mori (Silk moth) 361 0 GO:0004930; GO:0005886; GO:0016021; GO:0042562; GO:0042923 0 0 0 PF00001; Q9D180 CHOYP_MYS2.2.4 m.46072 sp CFA57_MOUSE 26.429 280 168 7 152 416 902 1158 7.70E-06 53.5 CFA57_MOUSE reviewed Cilia- and flagella-associated protein 57 (WD repeat-containing protein 65) Cfap57 Wdr65 Mus musculus (Mouse) 1249 0 0 0 0 0 PF00400; Q9MYM7 CHOYP_PHUM_PHUM029810.1.1 m.38616 sp B3GT1_PONPY 32.389 247 159 5 75 317 79 321 7.70E-43 154 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9NZJ4 CHOYP_BRAFLDRAFT_118535.3.8 m.35521 sp SACS_HUMAN 25.083 1806 1143 56 6 1710 2148 3844 7.70E-129 452 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9ULJ7 CHOYP_TVAG_470020.2.8 m.20056 sp ANR50_HUMAN 33.232 328 214 1 1 323 709 1036 7.70E-50 182 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; H3BS89 CHOYP_LOC100118354.3.4 m.66278 sp T178B_HUMAN 21.583 278 147 7 120 335 4 272 7.71E-07 53.5 T178B_HUMAN reviewed Transmembrane protein 178B TMEM178B Homo sapiens (Human) 294 0 GO:0016021 0 0 0 PF13903; P08011 CHOYP_MGST1.1.1 m.21583 sp MGST1_RAT 45.833 144 73 1 6 144 8 151 7.71E-41 136 MGST1_RAT reviewed Microsomal glutathione S-transferase 1 (Microsomal GST-1) (EC 2.5.1.18) (Microsomal GST-I) Mgst1 Gst12 Rattus norvegicus (Rat) 155 cellular response to lipid hydroperoxide [GO:0071449]; glutathione metabolic process [GO:0006749]; Leydig cell differentiation [GO:0033327]; protein homotrimerization [GO:0070207]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to organonitrogen compound [GO:0010243] GO:0004364; GO:0004602; GO:0005634; GO:0005739; GO:0005741; GO:0005743; GO:0005778; GO:0005783; GO:0005789; GO:0006749; GO:0010243; GO:0016021; GO:0032496; GO:0033327; GO:0042493; GO:0042802; GO:0042803; GO:0043295; GO:0045177; GO:0070207; GO:0071449 0 0 0 PF01124; P31596 CHOYP_EAA2.1.3 m.33694 sp EAA2_RAT 32.981 473 256 7 10 421 39 511 7.71E-75 247 EAA2_RAT reviewed Excitatory amino acid transporter 2 (GLT-1) (Sodium-dependent glutamate/aspartate transporter 2) (GLUT-R) (Solute carrier family 1 member 2) Slc1a2 Eaat2 Glt1 Rattus norvegicus (Rat) 573 L-glutamate transport [GO:0015813]; neurotransmitter transport [GO:0006836] GO:0005314; GO:0005886; GO:0006836; GO:0015813; GO:0016021; GO:0042734; GO:0043005; GO:0043197; GO:0043198; GO:0045202 0 0 0 PF00375; P59024 CHOYP_FKBP14.1.1 m.7244 sp FKB14_MOUSE 33.898 177 111 3 36 208 31 205 7.71E-31 115 FKB14_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase FKBP14 (PPIase FKBP14) (EC 5.2.1.8) (FK506-binding protein 14) (FKBP-14) (Rotamase) Fkbp14 Mus musculus (Mouse) 211 chaperone-mediated protein folding [GO:0061077] GO:0003755; GO:0005509; GO:0005528; GO:0005788; GO:0005789; GO:0061077 0 0 0 PF13499;PF00254; Q14162 CHOYP_MEG10.1.91 m.26 sp SREC_HUMAN 37.113 97 58 2 186 282 299 392 7.71E-10 63.2 SREC_HUMAN reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I) SCARF1 KIAA0149 SREC Homo sapiens (Human) 830 cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0004888; GO:0005044; GO:0005886; GO:0006707; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0030666; GO:0048680 0 0 0 PF00053; Q3SZ90 CHOYP_LOC100708460.1.1 m.43658 sp RL13A_BOVIN 58.763 194 79 1 245 437 8 201 7.71E-74 233 RL13A_BOVIN reviewed 60S ribosomal protein L13a RPL13A Bos taurus (Bovine) 203 negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; translation [GO:0006412] GO:0003729; GO:0003735; GO:0006412; GO:0017148; GO:0022625; GO:0097452; GO:1901194 0 0 cd00392; PF00572; Q3ZCD8 CHOYP_BRAFLDRAFT_63471.1.1 m.25619 sp MFF_BOVIN 27.014 211 122 10 56 244 9 209 7.71E-06 48.9 MFF_BOVIN reviewed Mitochondrial fission factor MFF Bos taurus (Bovine) 218 mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein targeting to membrane [GO:0090314] GO:0000266; GO:0005777; GO:0008021; GO:0008053; GO:0030054; GO:0031307; GO:0042803; GO:0090141; GO:0090314 0 0 0 PF05644; Q5C9L6 CHOYP_NEMVEDRAFT_V1G237881.1.1 m.10098 sp CNMT_THLFG 37.092 337 203 5 4 335 29 361 7.71E-74 235 CNMT_THLFG reviewed (S)-coclaurine N-methyltransferase (TfCNMT) (EC 2.1.1.140) 0 Thalictrum flavum subsp. glaucum (Yellow meadow rue) 361 0 GO:0005737; GO:0030794 0 0 0 PF02353; Q8WVZ9 CHOYP_BACH1.13.17 m.30031 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 7.71E-09 62.4 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q96QE2 CHOYP_MYCT.1.2 m.16478 sp MYCT_HUMAN 43.094 181 72 3 36 185 6 186 7.71E-35 132 MYCT_HUMAN reviewed Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) (H(+)-myo-inositol symporter) (Solute carrier family 2 member 13) SLC2A13 Homo sapiens (Human) 648 glucose import [GO:0046323]; hexose transmembrane transport [GO:0035428] GO:0005351; GO:0005355; GO:0005366; GO:0005886; GO:0005887; GO:0035428; GO:0046323 0 0 cd06174; PF00083; Q9NUA8 CHOYP_LOC100186276.4.5 m.12980 sp ZBT40_HUMAN 29.839 124 82 2 11 134 4 122 7.71E-06 53.5 ZBT40_HUMAN reviewed Zinc finger and BTB domain-containing protein 40 ZBTB40 KIAA0478 Homo sapiens (Human) 1239 "bone mineralization [GO:0030282]; cellular response to DNA damage stimulus [GO:0006974]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0006974; GO:0030282; GO:0046872 0 0 0 PF00651; Q9VUJ0 CHOYP_DGRI_GH14833.1.1 m.14206 sp RM39_DROME 42.199 282 155 6 52 330 37 313 7.71E-76 239 RM39_DROME reviewed "39S ribosomal protein L39, mitochondrial (MRP-L39) (MRP-L5)" mRpL39 mRpL5 CG17166 Drosophila melanogaster (Fruit fly) 333 gene silencing by RNA [GO:0031047]; mitochondrial genome maintenance [GO:0000002]; regulation of translation [GO:0006417]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418] GO:0000002; GO:0000166; GO:0003723; GO:0003735; GO:0005739; GO:0005762; GO:0006412; GO:0006417; GO:0006418; GO:0016876; GO:0031047 0 0 0 0 O13356 CHOYP_LOC100212386.1.2 m.33906 sp CHS1_CRYNH 30.333 300 155 11 622 886 571 851 7.72E-22 107 CHS1_CRYNH reviewed Chitin synthase 1 (EC 2.4.1.16) (Chitin-UDP acetyl-glucosaminyl transferase 1) (Class-IV chitin synthase 1) CHS1 CNAG_03099 Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 1236 cell wall organization [GO:0071555] GO:0004100; GO:0005886; GO:0016021; GO:0071555 0 0 0 0 O75382 CHOYP_LOC100369333.1.32 m.3585 sp TRIM3_HUMAN 24.286 280 163 13 301 554 488 744 7.72E-08 58.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P02637 CHOYP_SCP.12.12 m.66584 sp SCP_MIZYE 32.778 180 109 6 2 180 2 170 7.72E-26 100 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P40199 CHOYP_BRAFLDRAFT_78749.2.5 m.24526 sp CEAM6_HUMAN 25.862 290 162 15 114 377 40 302 7.72E-08 58.5 CEAM6_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 6 (Non-specific crossreacting antigen) (Normal cross-reacting antigen) (CD antigen CD66c) CEACAM6 NCA Homo sapiens (Human) 344 cell-cell signaling [GO:0007267]; leukocyte migration [GO:0050900]; signal transduction [GO:0007165] GO:0005615; GO:0005886; GO:0005887; GO:0007165; GO:0007267; GO:0031225; GO:0050900 0 0 0 PF13895;PF07686; Q3SZJ4 CHOYP_BRAFLDRAFT_90405.1.1 m.44167 sp PTGR1_BOVIN 54.03 335 144 10 31 361 1 329 7.72E-107 335 PTGR1_BOVIN reviewed Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74) PTGR1 LTB4DH Bos taurus (Bovine) 329 0 GO:0005737; GO:0008270; GO:0032440; GO:0036132; GO:0047522 0 0 0 PF00107; Q460N3 CHOYP_LOC100484022.1.2 m.56858 sp PAR15_HUMAN 24.366 710 381 27 52 726 88 676 7.72E-35 144 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q56R14 CHOYP_LIN41.3.3 m.51113 sp TRI33_XENLA 25.552 317 212 10 20 327 96 397 7.72E-16 85.5 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q80YR5 CHOYP_LOC100540564.1.1 m.9508 sp SAFB2_MOUSE 44.037 109 49 2 19 127 17 113 7.72E-13 70.1 SAFB2_MOUSE reviewed Scaffold attachment factor B2 (SAF-B2) Safb2 Mus musculus (Mouse) 991 "regulation of androgen receptor signaling pathway [GO:0060765]; regulation of transcription, DNA-templated [GO:0006355]; Sertoli cell differentiation [GO:0060008]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0042802; GO:0043231; GO:0044822; GO:0060008; GO:0060765; GO:0070062 0 0 0 PF00076;PF02037; Q8BYI9 CHOYP_LOC101161423.1.1 m.63055 sp TENR_MOUSE 51.034 145 66 2 9 149 1164 1307 7.72E-48 168 TENR_MOUSE reviewed Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Mus musculus (Mouse) 1358 "associative learning [GO:0008306]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; modulation of synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007158; GO:0008306; GO:0009986; GO:0010977; GO:0022029; GO:0022408; GO:0030198; GO:0030517; GO:0035641; GO:0045121; GO:0046625; GO:0048692; GO:0050804; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF00147;PF00041; Q8C6L5 CHOYP_NEMVEDRAFT_V1G218264.5.14 m.24087 sp CGAS_MOUSE 26.506 166 104 5 53 203 318 480 7.72E-08 58.5 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q9D8U4 CHOYP_BRAFLDRAFT_124212.1.1 m.64306 sp C1QT2_MOUSE 34.286 105 64 3 56 160 160 259 7.72E-09 57 C1QT2_MOUSE reviewed Complement C1q tumor necrosis factor-related protein 2 (mCTRP2) C1qtnf2 Crtp2 Mus musculus (Mouse) 294 activation of MAPK activity [GO:0000187]; positive regulation of fatty acid oxidation [GO:0046321]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; protein heterotrimerization [GO:0070208]; protein homooligomerization [GO:0051260]; protein trimerization [GO:0070206] GO:0000187; GO:0005102; GO:0005581; GO:0005615; GO:0042802; GO:0045725; GO:0046321; GO:0046326; GO:0051260; GO:0070206; GO:0070208 0 0 0 PF00386;PF01391; Q9SUL1 CHOYP_BRAFLDRAFT_77225.2.2 m.42661 sp RD19C_ARATH 36.538 208 127 4 13 216 31 237 7.72E-29 118 RD19C_ARATH reviewed Probable cysteine protease RD19C (EC 3.4.22.-) (RD19-like protein 2) RD19C RDL2 At4g16190 dl4135w Arabidopsis thaliana (Mouse-ear cress) 373 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0005773; GO:0051603 0 0 0 PF08246;PF00112; Q9ULI1 CHOYP_LOC100744637.1.1 m.55029 sp NWD2_HUMAN 26.576 1682 1081 48 27 1611 23 1647 7.72E-170 562 NWD2_HUMAN reviewed NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 0 0 0 0 0 PF13271; A2VE15 CHOYP_LOC100374197.1.1 m.56188 sp FADS6_BOVIN 45.231 325 176 2 31 353 18 342 7.73E-103 309 FADS6_BOVIN reviewed Fatty acid desaturase 6 (EC 1.14.19.-) FADS6 Bos taurus (Bovine) 342 fatty acid biosynthetic process [GO:0006633] GO:0006633; GO:0016021; GO:0016491 PATHWAY: Lipid metabolism; fatty acid metabolism. 0 0 PF00487; A4IF63 CHOYP_contig_028961 m.32895 sp TRIM2_BOVIN 23.871 155 111 3 104 254 592 743 7.73E-07 53.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O18783 CHOYP_PLMN.9.11 m.47619 sp PLMN_MACEU 37.593 540 224 23 617 1084 57 555 7.73E-81 284 PLMN_MACEU reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Macropus eugenii (Tammar wallaby) 806 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P19351 CHOYP_SMP_179810.2.3 m.2315 sp TNNT_DROME 41.667 180 101 3 34 211 52 229 7.73E-19 86.7 TNNT_DROME reviewed "Troponin T, skeletal muscle (Protein intended thorax) (Protein upheld)" up int CG7107 Drosophila melanogaster (Fruit fly) 397 cellular calcium ion homeostasis [GO:0006874]; mesoderm development [GO:0007498]; mitochondrion organization [GO:0007005]; muscle cell cellular homeostasis [GO:0046716]; muscle organ morphogenesis [GO:0048644]; myofibril assembly [GO:0030239]; regulation of muscle contraction [GO:0006937]; sarcomere organization [GO:0045214]; skeletal muscle thin filament assembly [GO:0030240] GO:0005509; GO:0005861; GO:0005865; GO:0006874; GO:0006937; GO:0007005; GO:0007498; GO:0030239; GO:0030240; GO:0045214; GO:0046716; GO:0048644 0 0 0 PF00992; Q4PMB3 CHOYP_BRAFLDRAFT_215239.3.3 m.22953 sp RS4_IXOSC 78.659 164 35 0 2 165 67 230 7.73E-95 278 RS4_IXOSC reviewed 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) 262 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q5IS54 CHOYP_LOC100638885.3.4 m.48269 sp CASP3_PANTR 29.94 167 89 3 129 292 32 173 7.73E-15 78.2 CASP3_PANTR reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Pan troglodytes (Chimpanzee) 277 B cell homeostasis [GO:0001782]; cell fate commitment [GO:0045165]; cellular response to DNA damage stimulus [GO:0006974]; erythrocyte differentiation [GO:0030218]; execution phase of apoptosis [GO:0097194]; glial cell apoptotic process [GO:0034349]; heart development [GO:0007507]; keratinocyte differentiation [GO:0030216]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of apoptotic process [GO:0043066]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neurotrophin TRK receptor signaling pathway [GO:0048011]; protein processing [GO:0016485]; response to UV [GO:0009411]; response to wounding [GO:0009611]; sensory perception of sound [GO:0007605]; T cell homeostasis [GO:0043029] GO:0001782; GO:0004190; GO:0004861; GO:0005634; GO:0005737; GO:0005829; GO:0006974; GO:0007507; GO:0007605; GO:0009411; GO:0009611; GO:0016485; GO:0030182; GO:0030216; GO:0030218; GO:0030889; GO:0034349; GO:0043029; GO:0043066; GO:0045165; GO:0045736; GO:0046007; GO:0048011; GO:0051402; GO:0097194; GO:0097200 0 0 0 0 Q640B4 CHOYP_LOC100180920.1.1 m.17133 sp MUS81_XENTR 46.012 326 162 3 435 753 294 612 7.73E-91 300 MUS81_XENTR reviewed Crossover junction endonuclease MUS81 (EC 3.1.22.-) mus81 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 612 DNA recombination [GO:0006310]; DNA repair [GO:0006281] GO:0003677; GO:0005634; GO:0006281; GO:0006310; GO:0008821; GO:0046872; GO:0048476 0 0 0 PF02732; Q6PAY6 CHOYP_PROD2.1.3 m.51180 sp PROD2_XENLA 41.687 403 230 4 77 479 53 450 7.73E-109 334 PROD2_XENLA reviewed Probable proline dehydrogenase 2 (EC 1.5.5.2) (Probable proline oxidase 2) prodh2 Xenopus laevis (African clawed frog) 466 proline catabolic process to glutamate [GO:0010133] GO:0004657; GO:0010133 PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2. 0 0 PF01619; Q6ZTW0 CHOYP_BRAFLDRAFT_121821.1.2 m.25121 sp TPGS1_HUMAN 24.113 141 73 4 19 141 33 157 7.73E-08 53.1 TPGS1_HUMAN reviewed Tubulin polyglutamylase complex subunit 1 (PGs1) TPGS1 C19orf20 Homo sapiens (Human) 290 adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; protein polyglutamylation [GO:0018095]; sperm axoneme assembly [GO:0007288]; vesicle localization [GO:0051648] GO:0005737; GO:0005813; GO:0005874; GO:0007268; GO:0007275; GO:0007288; GO:0018095; GO:0030424; GO:0030425; GO:0030534; GO:0031514; GO:0051648; GO:0070740 0 0 0 0 Q8IVI9 CHOYP_PHUM_PHUM498480.1.1 m.44970 sp NOSTN_HUMAN 28.462 260 185 1 22 280 8 267 7.73E-27 112 NOSTN_HUMAN reviewed Nostrin (BM247 homolog) (Nitric oxide synthase traffic inducer) (Nitric oxide synthase trafficker) (eNOS-trafficking inducer) NOSTRIN Homo sapiens (Human) 506 "endocytosis [GO:0006897]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of nitric-oxide synthase activity [GO:0050999]; signal transduction [GO:0007165]" GO:0003677; GO:0005634; GO:0005856; GO:0005886; GO:0006897; GO:0007165; GO:0030666; GO:0045892; GO:0050999 0 0 0 PF00611;PF14604; Q8IZ73 CHOYP_DVIR_GJ14588.1.1 m.25420 sp RUSD2_HUMAN 39.736 531 260 12 37 553 61 545 7.73E-120 367 RUSD2_HUMAN reviewed RNA pseudouridylate synthase domain-containing protein 2 RPUSD2 C15orf19 Homo sapiens (Human) 545 tRNA pseudouridine synthesis [GO:0031119] GO:0005739; GO:0009982; GO:0031119; GO:0044822 0 0 0 PF00849; Q91Z92 CHOYP_LOC585022.1.1 m.11698 sp B3GT6_MOUSE 43.824 340 163 5 9 340 5 324 7.73E-93 282 B3GT6_MOUSE reviewed "Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (EC 2.4.1.134) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6)" B3galt6 Mus musculus (Mouse) 325 chondroitin sulfate biosynthetic process [GO:0030206]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; protein glycosylation [GO:0006486] GO:0000139; GO:0005797; GO:0006024; GO:0006486; GO:0008499; GO:0015012; GO:0016020; GO:0016021; GO:0030206; GO:0035250; GO:0047220 PATHWAY: Glycan metabolism; chondroitin sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. 0 0 PF01762; Q92193 CHOYP_ACT.6.27 m.15622 sp ACT_CRAVI 89.888 267 10 1 3 269 1 250 7.73E-178 493 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q96M86 CHOYP_LOC100376274.1.7 m.20080 sp DNHD1_HUMAN 28.393 560 361 11 70 619 58 587 7.73E-59 217 DNHD1_HUMAN reviewed Dynein heavy chain domain-containing protein 1 (Dynein heavy chain domain 1-like protein) (Protein CCDC35) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) 4753 microtubule-based movement [GO:0007018] GO:0003777; GO:0007018; GO:0030286; GO:0070062 0 0 0 PF08393;PF03028;PF12777; Q9ESN6 CHOYP_TRIM2.48.59 m.53349 sp TRIM2_MOUSE 29.358 218 135 9 60 268 536 743 7.73E-13 71.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H270 CHOYP_VPS11.2.3 m.12430 sp VPS11_HUMAN 45.283 106 44 1 8 99 3 108 7.73E-25 100 VPS11_HUMAN reviewed Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) VPS11 RNF108 PP3476 Homo sapiens (Human) 941 autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vesicle docking involved in exocytosis [GO:0006904] GO:0000166; GO:0005764; GO:0005765; GO:0005768; GO:0005769; GO:0005770; GO:0005776; GO:0006886; GO:0006904; GO:0006914; GO:0007032; GO:0007040; GO:0008270; GO:0008333; GO:0019904; GO:0019905; GO:0030136; GO:0030139; GO:0030674; GO:0030897; GO:0031647; GO:0031902; GO:0034058; GO:0035542; GO:1902115; GO:1903364; GO:1903955; GO:2000643 0 0 0 PF00637;PF12451; Q9NZR2 CHOYP_LOC578599.6.8 m.43108 sp LRP1B_HUMAN 26.936 891 591 29 117 983 1328 2182 7.73E-86 313 LRP1B_HUMAN reviewed Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) LRP1B LRPDIT Homo sapiens (Human) 4599 protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898] GO:0005509; GO:0006898; GO:0015031; GO:0016021; GO:0043235 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; Q9Z1T4 CHOYP_CNKR2.2.3 m.55715 sp CNKR2_RAT 36.747 166 98 3 23 182 539 703 7.73E-27 113 CNKR2_RAT reviewed Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin) Cnksr2 Rattus norvegicus (Rat) 1032 regulation of signal transduction [GO:0009966] GO:0005794; GO:0009966; GO:0042802; GO:0043005; GO:0043025; GO:0045211; GO:0070062 0 0 0 PF10534;PF06663;PF00595;PF00169;PF00536; A6BM72 CHOYP_LOC101242430.2.2 m.36769 sp MEG11_HUMAN 50 48 22 2 55 101 374 420 7.74E-06 51.2 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q15262 CHOYP_PTPRM.14.15 m.57240 sp PTPRK_HUMAN 35.28 428 242 12 354 755 886 1304 7.74E-63 234 PTPRK_HUMAN reviewed Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48) PTPRK PTPK Homo sapiens (Human) 1439 "cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0001750; GO:0004725; GO:0005001; GO:0005887; GO:0005911; GO:0005912; GO:0006470; GO:0007155; GO:0007165; GO:0007179; GO:0008013; GO:0008285; GO:0009986; GO:0010839; GO:0016021; GO:0016477; GO:0019901; GO:0030336; GO:0030424; GO:0030425; GO:0031175; GO:0031256; GO:0034394; GO:0034614; GO:0034644; GO:0043025; GO:0045295; GO:0045786; GO:0045892; GO:0048041 0 0 cd06263; PF00041;PF07679;PF00629;PF00102; Q64230 CHOYP_NAS14.1.1 m.20317 sp MEP1A_RAT 35.498 231 136 6 96 323 43 263 7.74E-28 122 MEP1A_RAT reviewed Meprin A subunit alpha (EC 3.4.24.18) (Endopeptidase-2) (Endopeptidase-24.18 subunit alpha) (E-24.18) (MEP-1) Mep1a Rattus norvegicus (Rat) 748 proteolysis [GO:0006508] GO:0004222; GO:0006508; GO:0008270; GO:0017090; GO:0070062 0 0 cd06263; PF01400;PF00008;PF00629; Q6DFQ7 CHOYP_LOC100549883.1.1 m.65214 sp TM198_XENTR 52.5 40 19 0 49 88 25 64 7.74E-09 54.7 TM198_XENTR reviewed Transmembrane protein 198 tmem198 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 342 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005886; GO:0007275; GO:0012506; GO:0016021; GO:0016023; GO:0016055 0 0 0 PF13886; Q6N075 CHOYP_LOC574704.1.1 m.13176 sp MFSD5_HUMAN 43.409 440 247 2 7 445 6 444 7.74E-127 378 MFSD5_HUMAN reviewed Molybdate-anion transporter (Major facilitator superfamily domain-containing protein 5) (Molybdate transporter 2 homolog) (hsMOT2) MFSD5 UNQ832/PRO1759 Homo sapiens (Human) 450 0 GO:0005886; GO:0015098; GO:0016020; GO:0016021 0 0 0 PF05631; Q8VDY9 CHOYP_LOC658322.1.1 m.9325 sp CAAP1_MOUSE 35.088 114 65 2 52 165 107 211 7.74E-11 65.1 CAAP1_MOUSE reviewed Caspase activity and apoptosis inhibitor 1 (Conserved anti-apoptotic protein) (CAAP) Caap1 Caap Mus musculus (Mouse) 356 apoptotic process [GO:0006915] GO:0006915 0 0 0 0 Q95KU9 CHOYP_BRAFLDRAFT_121138.1.1 m.787 sp NEMO_BOVIN 28.465 404 221 13 313 702 70 419 7.74E-25 111 NEMO_BOVIN reviewed NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) IKBKG NEMO Bos taurus (Bovine) 419 "cellular response to DNA damage stimulus [GO:0006974]; establishment of vesicle localization [GO:0051650]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0000151; GO:0000922; GO:0005634; GO:0006351; GO:0006974; GO:0008385; GO:0042803; GO:0043123; GO:0045944; GO:0046872; GO:0046982; GO:0051092; GO:0051650; GO:0070530; GO:0072686 0 0 0 PF16516;PF11577; Q9NWY4 CHOYP_LOC584680.1.1 m.14553 sp HPF1_HUMAN 51.118 313 149 2 107 419 36 344 7.74E-112 335 HPF1_HUMAN reviewed Histone PARylation factor 1 HPF1 C4orf27 Homo sapiens (Human) 346 cellular response to DNA damage stimulus [GO:0006974]; regulation of protein ADP-ribosylation [GO:0010835] GO:0005634; GO:0006974; GO:0010835; GO:0042393 0 0 0 PF10228; D2GXS7 CHOYP_contig_054243 m.64750 sp TRIM2_AILME 23.448 145 104 3 32 172 602 743 7.75E-07 51.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O08726 CHOYP_BRAFLDRAFT_77391.3.3 m.55231 sp GALR2_RAT 33.121 157 93 5 2 153 22 171 7.75E-12 69.3 GALR2_RAT reviewed Galanin receptor type 2 (GAL2-R) (GALR-2) Galr2 Galnr2 Rattus norvegicus (Rat) 372 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; G-protein coupled receptor signaling pathway [GO:0007186]; inositol phosphate metabolic process [GO:0043647]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron projection development [GO:0031175]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of large conductance calcium-activated potassium channel activity [GO:1902608]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0004966; GO:0005886; GO:0005887; GO:0007186; GO:0007189; GO:0007194; GO:0007200; GO:0007204; GO:0017046; GO:0031175; GO:0042923; GO:0043647; GO:0045944; GO:0046488; GO:1902608 0 0 0 PF00001; O17320 CHOYP_ACT.18.27 m.45537 sp ACT_CRAGI 96.089 179 7 0 1 179 177 355 7.75E-124 361 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; O18404 CHOYP_BRAFLDRAFT_291364.1.1 m.47990 sp HCD2_DROME 55.556 144 64 0 2 145 50 193 7.75E-56 179 HCD2_DROME reviewed 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Scully protein) (Type II HADH) scu CG7113 Drosophila melanogaster (Fruit fly) 255 acyl-CoA metabolic process [GO:0006637]; androgen metabolic process [GO:0008209]; ecdysone metabolic process [GO:0008205]; estrogen metabolic process [GO:0008210]; fatty acid metabolic process [GO:0006631]; steroid metabolic process [GO:0008202]; tRNA processing [GO:0008033] GO:0003857; GO:0004303; GO:0005739; GO:0005811; GO:0005829; GO:0005875; GO:0006631; GO:0006637; GO:0008033; GO:0008202; GO:0008205; GO:0008209; GO:0008210; GO:0016229; GO:0018454; GO:0030283; GO:0047015; GO:0047022; GO:0047035 0 0 0 PF00106; O57592 CHOYP_LOC100366813.2.6 m.15339 sp RL7A_TAKRU 68.681 182 55 1 35 216 20 199 7.75E-87 261 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; O60290 CHOYP_LOC100494374.1.1 m.101 sp ZN862_HUMAN 25.877 228 160 6 217 444 546 764 7.75E-15 81.3 ZN862_HUMAN reviewed Zinc finger protein 862 ZNF862 KIAA0543 Homo sapiens (Human) 1169 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003676; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF05699;PF01352; P10160 CHOYP_EIF5A.1.3 m.22684 sp IF5A1_RABIT 64.557 158 51 2 1 158 1 153 7.75E-71 213 IF5A1_RABIT reviewed Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) EIF5A Oryctolagus cuniculus (Rabbit) 154 mRNA transport [GO:0051028]; positive regulation of translation [GO:0045727]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; protein transport [GO:0015031]; translational frameshifting [GO:0006452] GO:0003746; GO:0005643; GO:0005789; GO:0006452; GO:0015031; GO:0043022; GO:0045727; GO:0045901; GO:0045905; GO:0051028 0 0 0 PF01287; P10160 CHOYP_LOC100632169.4.6 m.51809 sp IF5A1_RABIT 64.557 158 51 2 1 158 1 153 7.75E-71 213 IF5A1_RABIT reviewed Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (eIF-4D) EIF5A Oryctolagus cuniculus (Rabbit) 154 mRNA transport [GO:0051028]; positive regulation of translation [GO:0045727]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; protein transport [GO:0015031]; translational frameshifting [GO:0006452] GO:0003746; GO:0005643; GO:0005789; GO:0006452; GO:0015031; GO:0043022; GO:0045727; GO:0045901; GO:0045905; GO:0051028 0 0 0 PF01287; P70031 CHOYP_LOC764372.1.1 m.25299 sp CCKAR_XENLA 26.263 198 142 3 36 231 73 268 7.75E-12 70.5 CCKAR_XENLA reviewed Cholecystokinin receptor (CCK-XLR) cckar Xenopus laevis (African clawed frog) 453 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q01528 CHOYP_LOC100127280.1.1 m.4532 sp HAAF_LIMPO 40.462 173 100 2 1 171 1 172 7.75E-44 146 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q66S03 CHOYP_CLC10.2.5 m.4673 sp LECG_THANI 25.595 168 110 5 5 166 1 159 7.75E-12 63.2 LECG_THANI reviewed Galactose-specific lectin nattectin (CTL) 0 Thalassophryne nattereri (Niquim) 159 inflammatory response [GO:0006954] GO:0005576; GO:0006954; GO:0030246; GO:0046872 0 0 0 PF00059; Q6R7B4 CHOYP_Y003.1.1 m.31011 sp Y003_OSHVF 71.795 156 30 3 1 148 1 150 7.75E-64 199 Y003_OSHVF reviewed Uncharacterized protein ORF3 ORF3 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 254 0 0 0 0 0 0 Q9HC62 CHOYP_UREG_00336.1.1 m.58183 sp SENP2_HUMAN 27.564 156 106 4 213 361 397 552 7.75E-11 67.8 SENP2_HUMAN reviewed Sentrin-specific protease 2 (EC 3.4.22.68) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 Homo sapiens (Human) 589 "dorsal/ventral axis specification [GO:0009950]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; labyrinthine layer development [GO:0060711]; mRNA transport [GO:0051028]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of DNA endoreduplication [GO:0032875]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of Wnt signaling pathway [GO:0030111]; spongiotrophoblast layer development [GO:0060712]; trophoblast giant cell differentiation [GO:0060707]; Wnt signaling pathway [GO:0016055]" GO:0001934; GO:0004175; GO:0005643; GO:0005654; GO:0007507; GO:0009950; GO:0015031; GO:0016055; GO:0016605; GO:0016925; GO:0016926; GO:0016929; GO:0030111; GO:0031397; GO:0031398; GO:0031410; GO:0031648; GO:0031965; GO:0032091; GO:0032875; GO:0035562; GO:0043518; GO:0045444; GO:0045944; GO:0051028; GO:0060707; GO:0060711; GO:0060712; GO:0070139; GO:2000045 0 0 0 PF02902; Q9LQV2 CHOYP_BRAFLDRAFT_81564.1.1 m.61478 sp RDR1_ARATH 46.97 264 137 2 8 269 742 1004 7.75E-71 241 RDR1_ARATH reviewed RNA-dependent RNA polymerase 1 (AtRDRP1) (EC 2.7.7.48) (RNA-directed RNA polymerase 1) RDR1 RDRP1 At1g14790 F10B6.19 Arabidopsis thaliana (Mouse-ear cress) 1107 defense response [GO:0006952]; positive regulation of posttranscriptional gene silencing [GO:0060148]; production of siRNA involved in RNA interference [GO:0030422]; response to salicylic acid [GO:0009751]; response to virus [GO:0009615]; wax biosynthetic process [GO:0010025] GO:0000166; GO:0003723; GO:0003968; GO:0006952; GO:0009615; GO:0009751; GO:0010025; GO:0030422; GO:0060148 0 0 0 PF05183; A8Y1P7 CHOYP_LOC100866516.1.2 m.9713 sp BRE4_CAEBR 46.953 279 145 1 49 324 93 371 7.76E-92 281 BRE4_CAEBR reviewed "Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)" bre-4 CBG22165 Caenorhabditis briggsae 384 protein glycosylation [GO:0006486] GO:0006486; GO:0016021; GO:0016757; GO:0046872 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9GUM2}. 0 0 PF02709;PF13733; O75382 CHOYP_TRIM3.38.58 m.39430 sp TRIM3_HUMAN 24.269 342 195 17 35 331 422 744 7.76E-07 54.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P47911 CHOYP_BRAFLDRAFT_114734.5.8 m.18865 sp RL6_MOUSE 63 200 70 2 73 271 100 296 7.76E-80 245 RL6_MOUSE reviewed 60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) Rpl6 Mus musculus (Mouse) 296 cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0002181; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0016020; GO:0022625; GO:0036464; GO:0044822 0 0 0 PF01159;PF03868; P48148 CHOYP_AAEL_AAEL013139.1.2 m.31449 sp RHO1_DROME 62.887 194 70 2 1 194 1 192 7.76E-87 256 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; P55212 CHOYP_LOC100892193.4.5 m.59090 sp CASP6_HUMAN 35.316 269 154 6 346 607 35 290 7.76E-39 147 CASP6_HUMAN reviewed Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] CASP6 MCH2 Homo sapiens (Human) 293 apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; epithelial cell differentiation [GO:0030855]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0006921; GO:0008234; GO:0030855; GO:0042802; GO:0042981; GO:0097153 0 0 0 0 P86854 CHOYP_PLCL.3.8 m.57161 sp PLCL_MYTGA 26.984 126 82 6 33 156 30 147 7.76E-08 52 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q29550 CHOYP_SI_CH211-93F2.1.3.4 m.32315 sp EST1_PIG 33.813 556 323 14 668 1202 27 558 7.76E-83 285 EST1_PIG reviewed Liver carboxylesterase (EC 3.1.1.1) (Proline-beta-naphthylamidase) (Retinyl ester hydrolase) (REH) 0 Sus scrofa (Pig) 566 0 GO:0005788; GO:0052689 0 0 0 PF00135; Q641C9 CHOYP_CD123.1.1 m.46394 sp CD123_XENLA 50 340 161 5 1 335 1 336 7.76E-116 342 CD123_XENLA reviewed Cell division cycle protein 123 homolog cdc123 Xenopus laevis (African clawed frog) 338 cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005737; GO:0007049; GO:0051301 0 0 0 PF07065; Q8WXX7 CHOYP_LOC100376759.1.2 m.14953 sp AUTS2_HUMAN 31.25 416 182 17 356 687 422 817 7.76E-17 89.7 AUTS2_HUMAN reviewed Autism susceptibility gene 2 protein AUTS2 KIAA0442 Homo sapiens (Human) 1259 innate vocalization behavior [GO:0098582]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H4-K16 acetylation [GO:2000620]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; righting reflex [GO:0060013] GO:0003682; GO:0005634; GO:0045944; GO:0051571; GO:0060013; GO:0098582; GO:2000620 0 0 0 0 Q91YK0 CHOYP_BRAFLDRAFT_67566.2.4 m.11869 sp LRC49_MOUSE 63.314 169 61 1 61 229 56 223 7.76E-66 218 LRC49_MOUSE reviewed Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79) Lrrc49 Mus musculus (Mouse) 686 0 GO:0005737; GO:0005874 0 0 0 0 Q96CS7 CHOYP_PKHB1.1.1 m.7566 sp PKHB2_HUMAN 28.972 107 76 0 14 120 3 109 7.76E-15 72 PKHB2_HUMAN reviewed Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2) PLEKHB2 EVT2 Homo sapiens (Human) 222 regulation of cell differentiation [GO:0045595] GO:0016021; GO:0045595; GO:0055038 0 0 0 PF00169; Q9BTY2 CHOYP_FUCO2.1.1 m.64139 sp FUCO2_HUMAN 55.149 437 188 6 76 508 34 466 7.76E-178 511 FUCO2_HUMAN reviewed Plasma alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucoside fucohydrolase 2) (Alpha-L-fucosidase 2) FUCA2 PSEC0151 UNQ227/PRO260 Homo sapiens (Human) 467 fucose metabolic process [GO:0006004]; glycoside catabolic process [GO:0016139]; regulation of entry of bacterium into host cell [GO:2000535]; response to bacterium [GO:0009617] GO:0004560; GO:0005615; GO:0006004; GO:0009617; GO:0016139; GO:0070062; GO:2000535 0 0 0 PF01120;PF16757; O35671 CHOYP_ITBP1.1.1 m.56577 sp ITBP1_MOUSE 31.655 139 92 2 33 169 63 200 7.77E-19 82.4 ITBP1_MOUSE reviewed Integrin beta-1-binding protein 1 (Bodenin) Itgb1bp1 Mus musculus (Mouse) 200 "activation of protein kinase B activity [GO:0032148]; biomineral tissue development [GO:0031214]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; cell differentiation [GO:0030154]; cell-matrix adhesion [GO:0007160]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; myoblast migration [GO:0051451]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast migration [GO:0010764]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; Notch signaling pathway [GO:0007219]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein transport [GO:0015031]; receptor clustering [GO:0043113]; regulation of blood vessel size [GO:0050880]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of GTPase activity [GO:0043087]; regulation of integrin-mediated signaling pathway [GO:2001044]; transcription, DNA-templated [GO:0006351]; tube formation [GO:0035148]" GO:0001726; GO:0002043; GO:0005092; GO:0005178; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006351; GO:0006469; GO:0006933; GO:0007160; GO:0007219; GO:0007229; GO:0008022; GO:0008284; GO:0008285; GO:0008565; GO:0010595; GO:0010764; GO:0015031; GO:0019900; GO:0019901; GO:0030027; GO:0030154; GO:0030155; GO:0031214; GO:0032091; GO:0032148; GO:0032403; GO:0033622; GO:0033628; GO:0035148; GO:0035924; GO:0043087; GO:0043113; GO:0044344; GO:0045747; GO:0045944; GO:0048471; GO:0050880; GO:0051451; GO:0051496; GO:0051781; GO:0051894; GO:0051895; GO:0051897; GO:0070062; GO:0070373; GO:0071944; GO:0090051; GO:0090314; GO:0090315; GO:1900025; GO:2001044 0 0 0 PF10480; O95236 CHOYP_APOL4.1.1 m.36181 sp APOL3_HUMAN 24.51 204 133 3 870 1052 173 376 7.77E-08 59.7 APOL3_HUMAN reviewed Apolipoprotein L3 (Apolipoprotein L-III) (ApoL-III) (TNF-inducible protein CG12-1) (CG12_1) APOL3 Homo sapiens (Human) 402 inflammatory response [GO:0006954]; lipoprotein metabolic process [GO:0042157]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0005319; GO:0005576; GO:0005737; GO:0006954; GO:0008289; GO:0016020; GO:0042157; GO:0043123 0 0 0 PF05461; P52168 CHOYP_GATA1.1.2 m.16576 sp PNR_DROME 61.333 150 30 3 310 459 160 281 7.77E-52 191 PNR_DROME reviewed GATA-binding factor A (Protein pannier) (Transcription factor GATA-A) (dGATA-A) pnr GATA-A CG3978 Drosophila melanogaster (Fruit fly) 540 "anatomical structure formation involved in morphogenesis [GO:0048646]; blastoderm segmentation [GO:0007350]; cardioblast cell fate determination [GO:0007510]; cardioblast differentiation [GO:0010002]; cardiocyte differentiation [GO:0035051]; cell development [GO:0048468]; cell differentiation [GO:0030154]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; digestive tract development [GO:0048565]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic heart tube development [GO:0035050]; heart contraction [GO:0060047]; heart development [GO:0007507]; lymph gland development [GO:0048542]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pattern specification process [GO:0007389]; pericardial nephrocyte differentiation [GO:0061320]; pigment metabolic process [GO:0042440]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of antimicrobial peptide biosynthetic process [GO:0002805]; regulation of glucose metabolic process [GO:0010906]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000122; GO:0000977; GO:0000981; GO:0000983; GO:0001085; GO:0001103; GO:0001228; GO:0002805; GO:0003682; GO:0003700; GO:0005634; GO:0005667; GO:0007179; GO:0007350; GO:0007389; GO:0007391; GO:0007398; GO:0007507; GO:0007510; GO:0008270; GO:0008407; GO:0010002; GO:0010906; GO:0022416; GO:0030154; GO:0035050; GO:0035051; GO:0042440; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0046982; GO:0048468; GO:0048542; GO:0048565; GO:0048646; GO:0060047; GO:0061320 0 0 0 PF00320; Q2TBS2 CHOYP_DANA_GF10776.1.1 m.18533 sp RM21_BOVIN 38.119 202 105 3 13 205 14 204 7.77E-31 115 RM21_BOVIN reviewed "39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21)" MRPL21 Bos taurus (Bovine) 209 mitochondrial translational elongation [GO:0070125]; mitochondrial translational initiation [GO:0070124] GO:0003735; GO:0005743; GO:0005762; GO:0070124; GO:0070125 0 0 0 PF00829; Q3B8G0 CHOYP_BRAFLDRAFT_120923.3.3 m.58916 sp CA123_XENLA 57.792 154 63 1 24 177 7 158 7.77E-65 199 CA123_XENLA reviewed UPF0587 protein C1orf123 homolog 0 Xenopus laevis (African clawed frog) 160 0 0 0 0 0 PF05907; Q4V885 CHOYP_LOC420516.1.1 m.48149 sp COL12_RAT 32.857 140 72 9 64 197 611 734 7.77E-11 66.2 COL12_RAT reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) (Nurse cell scavenger receptor 2) Colec12 Clp1 Nsr2 Rattus norvegicus (Rat) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; Q5THJ4 CHOYP_VP13D.3.3 m.63950 sp VP13D_HUMAN 50.862 116 53 2 15 129 4178 4290 7.77E-28 110 VP13D_HUMAN reviewed Vacuolar protein sorting-associated protein 13D VPS13D KIAA0453 Homo sapiens (Human) 4388 protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623] GO:0005622; GO:0006623; GO:0019898; GO:0045053; GO:0070062 0 0 0 PF12624;PF06650;PF00627;PF16908;PF16909;PF16910; Q80T85 CHOYP_LOC658743.1.1 m.13718 sp DCAF5_MOUSE 64.706 170 56 2 1 166 260 429 7.77E-69 239 DCAF5_MOUSE reviewed DDB1- and CUL4-associated factor 5 (WD repeat-containing protein 22) Dcaf5 Kiaa1824 Wdr22 Mus musculus (Mouse) 946 protein ubiquitination [GO:0016567] GO:0005739; GO:0016567; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q8IYT3 CHOYP_VATB.2.2 m.62084 sp CC170_HUMAN 35.917 671 421 5 123 791 39 702 7.77E-117 374 CC170_HUMAN reviewed Coiled-coil domain-containing protein 170 CCDC170 C6orf97 Homo sapiens (Human) 715 0 0 0 0 0 0 Q9NRA2 CHOYP_LOC659204.1.1 m.11013 sp S17A5_HUMAN 41.543 337 168 4 2 322 13 336 7.77E-85 267 S17A5_HUMAN reviewed Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) SLC17A5 Homo sapiens (Human) 495 amino acid transport [GO:0006865]; anion transport [GO:0006820]; ion transport [GO:0006811]; sialic acid transport [GO:0015739] GO:0005351; GO:0005737; GO:0005765; GO:0005886; GO:0005887; GO:0006811; GO:0006820; GO:0006865; GO:0015136; GO:0015538; GO:0015739; GO:0016020; GO:0030054; GO:0030672 0 0 cd06174; PF07690; A4IF63 CHOYP_BRAFLDRAFT_87279.9.10 m.46292 sp TRIM2_BOVIN 24.342 152 112 2 158 307 593 743 7.78E-07 54.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_TRIM3.28.58 m.32886 sp TRIM2_BOVIN 33.962 106 66 3 31 133 627 731 7.78E-10 59.3 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5D6U8 CHOYP_LOC100370821.1.2 m.33173 sp ACP7_DANRE 37.143 420 229 12 36 431 31 439 7.78E-74 243 ACP7_DANRE reviewed Acid phosphatase type 7 (EC 3.1.3.2) (Purple acid phosphatase long form) acp7 papl zgc:162913 Danio rerio (Zebrafish) (Brachydanio rerio) 443 0 GO:0003993; GO:0005576; GO:0046872 0 0 0 PF00149;PF14008;PF16656; O43301 CHOYP_BRAFLDRAFT_208197.8.21 m.31259 sp HS12A_HUMAN 30.308 650 377 15 1 594 28 657 7.78E-90 295 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75382 CHOYP_BRAFLDRAFT_205965.40.43 m.64648 sp TRIM3_HUMAN 22.963 135 89 3 153 285 622 743 7.78E-06 50.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P16157 CHOYP_TVAG_099270.5.6 m.54161 sp ANK1_HUMAN 36.207 348 222 0 787 1134 220 567 7.78E-58 223 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P43689 CHOYP_TPM.2.19 m.4573 sp TPM2_BIOGL 67.879 165 53 0 1 165 1 165 7.78E-66 206 TPM2_BIOGL reviewed Tropomyosin-2 (Tropomyosin II) (BgTMII) (TMII) 0 Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) 284 0 0 0 0 0 PF00261; P46531 CHOYP_TRIADDRAFT_26633.2.6 m.34480 sp NOTC1_HUMAN 44.138 145 81 0 7 151 877 1021 7.78E-36 150 NOTC1_HUMAN reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 Homo sapiens (Human) 2555 "aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium morphogenesis [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; organ regeneration [GO:0031100]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral transcription [GO:0050434]; prostate gland epithelium morphogenesis [GO:0060740]; pulmonary valve morphogenesis [GO:0003184]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; tissue regeneration [GO:0042246]; transcription initiation from RNA polymerase II promoter [GO:0006367]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0000139; GO:0001047; GO:0001190; GO:0001669; GO:0001701; GO:0001708; GO:0001837; GO:0001889; GO:0001947; GO:0002040; GO:0002052; GO:0002193; GO:0002437; GO:0003157; GO:0003160; GO:0003162; GO:0003169; GO:0003180; GO:0003181; GO:0003184; GO:0003192; GO:0003198; GO:0003203; GO:0003207; GO:0003208; GO:0003209; GO:0003213; GO:0003214; GO:0003219; GO:0003222; GO:0003241; GO:0003256; GO:0003270; GO:0003273; GO:0003344; GO:0003700; GO:0004857; GO:0004872; GO:0005509; GO:0005576; GO:0005634; GO:0005654; GO:0005789; GO:0005829; GO:0005886; GO:0005912; GO:0006355; GO:0006367; GO:0006955; GO:0006959; GO:0007219; GO:0007221; GO:0007283; GO:0007368; GO:0007386; GO:0007409; GO:0007440; GO:0007492; GO:0007507; GO:0008284; GO:0008285; GO:0009912; GO:0009986; GO:0010718; GO:0010812; GO:0010832; GO:0014031; GO:0014807; GO:0016021; GO:0016324; GO:0019899; GO:0021515; GO:0021915; GO:0030216; GO:0030279; GO:0030324; GO:0030335; GO:0030513; GO:0030514; GO:0030900; GO:0031069; GO:0031100; GO:0031490; GO:0031960; GO:0032495; GO:0032496; GO:0035116; GO:0035148; GO:0035914; GO:0035924; GO:0042246; GO:0043065; GO:0043086; GO:0043235; GO:0043565; GO:0045070; GO:0045603; GO:0045608; GO:0045618; GO:0045662; GO:0045668; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0045955; GO:0046427; GO:0046533; GO:0048103; GO:0048708; GO:0048709; GO:0048711; GO:0048715; GO:0048754; GO:0050434; GO:0050679; GO:0050768; GO:0055008; GO:0060038; GO:0060045; GO:0060253; GO:0060271; GO:0060317; GO:0060411; GO:0060412; GO:0060528; GO:0060740; GO:0060768; GO:0060842; GO:0060843; GO:0060948; GO:0060956; GO:0060979; GO:0060982; GO:0061314; GO:0061384; GO:0061419; GO:0070986; GO:0071372; GO:0072017; GO:0072044; GO:0072144; GO:0072602; GO:0090051; GO:0090090; GO:0097150; GO:1901201; GO:1902263; GO:2000737; GO:2000811; GO:2000974; GO:2001027 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P49285 CHOYP_OPRM.1.1 m.4469 sp MTR1A_CHICK 23.077 338 233 10 33 349 19 350 7.78E-15 78.2 MTR1A_CHICK reviewed Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor) (CKA) 0 Gallus gallus (Chicken) 353 cell surface receptor signaling pathway [GO:0007166]; circadian rhythm [GO:0007623]; positive regulation of cGMP biosynthetic process [GO:0030828] GO:0005887; GO:0007166; GO:0007623; GO:0008502; GO:0030828; GO:0042562; GO:0043235; GO:0097159 0 0 0 PF00001; Q08E52 CHOYP_PAK1.1.1 m.50796 sp PAK1_BOVIN 51.471 476 199 7 42 495 75 540 7.78E-157 459 PAK1_BOVIN reviewed Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) PAK1 Bos taurus (Bovine) 544 actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; exocytosis [GO:0006887]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; wound healing [GO:0042060] GO:0001726; GO:0001934; GO:0004674; GO:0004702; GO:0005518; GO:0005524; GO:0005737; GO:0005794; GO:0005886; GO:0005911; GO:0005925; GO:0006468; GO:0006887; GO:0006915; GO:0007409; GO:0030036; GO:0030335; GO:0031532; GO:0032587; GO:0033138; GO:0033148; GO:0042060; GO:0043234; GO:0043507; GO:0046777; GO:0048754; GO:0051496; GO:0060244; GO:0071437 0 0 0 PF00786;PF00069; Q13490 CHOYP_BIRC2.5.13 m.24445 sp BIRC2_HUMAN 35.961 203 121 4 7 201 167 368 7.78E-33 129 BIRC2_HUMAN reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (TNFR2-TRAF-signaling complex protein 2) BIRC2 API1 MIHB RNF48 Homo sapiens (Human) 618 "cell surface receptor signaling pathway [GO:0007166]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; NIK/NF-kappaB signaling [GO:0038061]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of cell proliferation [GO:0042127]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006921; GO:0007166; GO:0007249; GO:0008270; GO:0009898; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0033209; GO:0034121; GO:0035631; GO:0035666; GO:0038061; GO:0039535; GO:0042127; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045088; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0070266; GO:0070424; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000116; GO:2000377 0 0 0 PF00653;PF00619; Q8BGC3 CHOYP_LOC100371611.1.1 m.23696 sp MOT12_MOUSE 27.189 434 281 6 31 429 19 452 7.78E-45 166 MOT12_MOUSE reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) Slc16a12 Mct12 Mus musculus (Mouse) 486 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q8WVZ9 CHOYP_LOC100163693.1.2 m.8739 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 7.78E-09 62.4 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q9QW30 CHOYP_LOC100638363.1.2 m.2543 sp NOTC2_RAT 31.183 1395 678 59 1400 2614 44 1336 7.78E-112 404 NOTC2_RAT reviewed Neurogenic locus notch homolog protein 2 (Notch 2) [Cleaved into: Notch 2 extracellular truncation; Notch 2 intracellular domain] Notch2 Rattus norvegicus (Rat) 2471 "cell cycle arrest [GO:0007050]; cell fate determination [GO:0001709]; cell growth [GO:0016049]; marginal zone B cell differentiation [GO:0002315]; negative regulation of cell proliferation [GO:0008285]; Notch signaling pathway [GO:0007219]; organ morphogenesis [GO:0009887]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of developmental process [GO:0050793]; regulation of transcription, DNA-templated [GO:0006355]; tissue regeneration [GO:0042246]; transcription, DNA-templated [GO:0006351]" GO:0001709; GO:0002315; GO:0004872; GO:0005509; GO:0005576; GO:0005634; GO:0005829; GO:0005886; GO:0005887; GO:0006351; GO:0006355; GO:0007050; GO:0007219; GO:0008285; GO:0009887; GO:0009986; GO:0016049; GO:0042246; GO:0046579; GO:0050793 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; Q9R1R2 CHOYP_BRAFLDRAFT_205965.42.43 m.64738 sp TRIM3_MOUSE 25.342 146 104 3 135 276 599 743 7.78E-08 57 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O15439 CHOYP_AGAP_AGAP006427.1.1 m.48620 sp MRP4_HUMAN 37.023 262 159 2 67 324 764 1023 7.79E-48 176 MRP4_HUMAN reviewed Multidrug resistance-associated protein 4 (ATP-binding cassette sub-family C member 4) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) ABCC4 MRP4 Homo sapiens (Human) 1325 cilium assembly [GO:0042384]; platelet degranulation [GO:0002576]; prostaglandin secretion [GO:0032310]; transmembrane transport [GO:0055085] GO:0002576; GO:0005524; GO:0005886; GO:0015662; GO:0016020; GO:0016021; GO:0016323; GO:0016404; GO:0031088; GO:0032310; GO:0042384; GO:0043225; GO:0055085 0 0 0 PF00664;PF00005; P11029 CHOYP_ACACA.1.7 m.10126 sp ACAC_CHICK 77.023 309 71 0 169 477 1678 1986 7.79E-163 512 ACAC_CHICK reviewed Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) [Includes: Biotin carboxylase (EC 6.3.4.14)] ACAC Gallus gallus (Chicken) 2324 "fatty acid biosynthetic process [GO:0006633]; malonyl-CoA biosynthetic process [GO:2001295]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of biological quality [GO:0065008]; regulation of gene expression, epigenetic [GO:0040029]; response to carbohydrate [GO:0009743]; response to fatty acid [GO:0070542]; response to thyroid hormone [GO:0097066]; transport [GO:0006810]" GO:0003989; GO:0004075; GO:0005102; GO:0005524; GO:0005623; GO:0005737; GO:0006633; GO:0006810; GO:0009374; GO:0009743; GO:0010628; GO:0032810; GO:0040029; GO:0045893; GO:0046872; GO:0046966; GO:0050692; GO:0065008; GO:0070542; GO:0097066; GO:2001295 PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. 0 0 PF08326;PF02785;PF00289;PF00364;PF01039;PF02786; Q19QU3 CHOYP_BRAFLDRAFT_150340.3.4 m.16172 sp ZRAB2_PIG 58.621 145 37 3 10 154 6 127 7.79E-51 176 ZRAB2_PIG reviewed Zinc finger Ran-binding domain-containing protein 2 (Zinc finger protein 265) ZRANB2 ZNF265 Sus scrofa (Pig) 328 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0006397; GO:0008270; GO:0008380; GO:0044822 0 0 0 PF00641; Q6L6Q6 CHOYP_LYS.1.2 m.40237 sp LYS_CRAGI 98.54 137 2 0 1 137 1 137 7.79E-98 280 LYS_CRAGI reviewed "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" lysoz Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 137 cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; metabolic process [GO:0008152] GO:0003796; GO:0005576; GO:0008152; GO:0019835; GO:0042742 0 0 0 PF05497; Q6L6Q6 CHOYP_LYS.2.2 m.66889 sp LYS_CRAGI 98.54 137 2 0 1 137 1 137 7.79E-98 280 LYS_CRAGI reviewed "Lysozyme (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase)" lysoz Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 137 cytolysis [GO:0019835]; defense response to bacterium [GO:0042742]; metabolic process [GO:0008152] GO:0003796; GO:0005576; GO:0008152; GO:0019835; GO:0042742 0 0 0 PF05497; Q7Z429 CHOYP_NEMVEDRAFT_V1G189239.1.1 m.25883 sp LFG1_HUMAN 44.541 229 124 2 32 258 144 371 7.79E-65 209 LFG1_HUMAN reviewed Protein lifeguard 1 (Glutamate [NMDA] receptor-associated protein 1) (NMDA receptor glutamate-binding subunit) (Putative MAPK-activating protein PM02) (Transmembrane BAX inhibitor motif-containing protein 3) GRINA LFG1 NMDARA1 TMBIM3 Homo sapiens (Human) 371 endoplasmic reticulum calcium ion homeostasis [GO:0032469]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236] GO:0005783; GO:0005794; GO:0016021; GO:0032469; GO:1902236 0 0 0 0 Q8K021 CHOYP_SCAM1.1.1 m.5509 sp SCAM1_MOUSE 51.775 338 137 4 1 336 1 314 7.79E-112 332 SCAM1_MOUSE reviewed Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) Scamp1 Mus musculus (Mouse) 338 exocytosis [GO:0006887]; protein transport [GO:0015031] GO:0005654; GO:0005802; GO:0006887; GO:0008021; GO:0015031; GO:0016021; GO:0030054; GO:0030672; GO:0042589; GO:0043231; GO:0045202; GO:0055038 0 0 0 PF04144; Q8TDB6 CHOYP_LOC100370200.5.5 m.62902 sp DTX3L_HUMAN 51.099 182 84 3 160 339 561 739 7.79E-55 194 DTX3L_HUMAN reviewed E3 ubiquitin-protein ligase DTX3L (EC 6.3.2.-) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (Rhysin-2) (Rhysin2) DTX3L BBAP Homo sapiens (Human) 740 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; histone monoubiquitination [GO:0010390]; protein polyubiquitination [GO:0000209] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006302; GO:0006974; GO:0008270; GO:0010390; GO:0016874; GO:0042393 PATHWAY: Protein modification; protein ubiquitination. 0 0 0 Q90W95 CHOYP_BRAFLDRAFT_85791.1.1 m.42987 sp PTPS_POERE 68.421 133 42 0 7 139 15 147 7.79E-70 209 PTPS_POERE reviewed 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) pts Poecilia reticulata (Guppy) (Acanthophacelus reticulatus) 147 tetrahydrobiopterin biosynthetic process [GO:0006729] GO:0003874; GO:0006729; GO:0046872 "PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3." 0 0 PF01242; Q92851 CHOYP_CASP7.20.23 m.62560 sp CASPA_HUMAN 35.507 138 70 6 17 150 280 402 7.79E-15 76.6 CASPA_HUMAN reviewed Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005829; GO:0006915; GO:0007166; GO:0008625; GO:0030225; GO:0031265; GO:0031625; GO:0035877; GO:0042981; GO:0043123; GO:0097190; GO:0097199; GO:0097342 0 0 0 PF01335; A4IH75 CHOYP_ATGA1.1.1 m.7142 sp ATGA1_XENTR 63.303 218 80 0 46 263 1 218 7.80E-110 318 ATGA1_XENTR reviewed Autophagy-related protein 101 atg101 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 218 autophagosome assembly [GO:0000045] GO:0000045; GO:0000407 0 0 0 PF07855; B3EWY9 CHOYP_contig_040975 m.46616 sp MLP_ACRMI 27.296 1165 691 42 206 1302 287 1363 7.80E-91 332 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; O60911 CHOYP_CATS.1.1 m.45218 sp CATL2_HUMAN 47.892 332 160 5 8 330 5 332 7.80E-107 318 CATL2_HUMAN reviewed Cathepsin L2 (EC 3.4.22.43) (Cathepsin U) (Cathepsin V) CTSV CATL2 CTSL2 CTSU UNQ268/PRO305 Homo sapiens (Human) 334 antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagic cell death [GO:0048102]; cellular response to starvation [GO:0009267]; decidualization [GO:0046697]; extracellular matrix disassembly [GO:0022617]; hair follicle morphogenesis [GO:0031069]; multicellular organism aging [GO:0010259]; negative regulation of keratinocyte proliferation [GO:0010839]; nerve development [GO:0021675]; protein autoprocessing [GO:0016540]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of actin cytoskeleton reorganization [GO:2000249]; response to glucocorticoid [GO:0051384]; response to glucose [GO:0009749]; response to gonadotropin [GO:0034698]; Sertoli cell differentiation [GO:0060008]; spermatogenesis [GO:0007283] GO:0004177; GO:0004197; GO:0004252; GO:0005576; GO:0005615; GO:0005730; GO:0005764; GO:0005902; GO:0007283; GO:0008234; GO:0009267; GO:0009749; GO:0009897; GO:0010259; GO:0010839; GO:0016540; GO:0016807; GO:0019886; GO:0021675; GO:0022617; GO:0030141; GO:0031069; GO:0034698; GO:0042277; GO:0043005; GO:0043202; GO:0043204; GO:0045177; GO:0046697; GO:0048102; GO:0051384; GO:0051603; GO:0060008; GO:0070062; GO:2000249 0 0 0 PF08246;PF00112; P09645 CHOYP_TBA1A.2.4 m.19573 sp TBA8_CHICK 92.369 249 17 1 22 270 78 324 7.80E-175 487 TBA8_CHICK reviewed Tubulin alpha-8 chain (Fragment) 0 Gallus gallus (Chicken) 324 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P98164 CHOYP_BRAFLDRAFT_132336.1.1 m.26677 sp LRP2_HUMAN 26.667 225 125 7 159 369 3591 3789 7.80E-10 65.1 LRP2_HUMAN reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) 4655 aorta development [GO:0035904]; cell proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; endocytosis [GO:0006897]; forebrain development [GO:0030900]; lipid metabolic process [GO:0006629]; protein glycosylation [GO:0006486]; receptor-mediated endocytosis [GO:0006898]; retinoid metabolic process [GO:0001523]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359] GO:0001523; GO:0003281; GO:0005041; GO:0005509; GO:0005764; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005905; GO:0006486; GO:0006629; GO:0006897; GO:0006898; GO:0008283; GO:0016021; GO:0016324; GO:0030139; GO:0030900; GO:0031526; GO:0035904; GO:0042359; GO:0042954; GO:0043235; GO:0060976; GO:0070062 0 0 0 PF12662;PF07645;PF00057;PF00058; Q28691 CHOYP_PE2R2.1.2 m.25106 sp PE2R4_RABIT 27.066 351 203 8 1 304 5 349 7.80E-35 135 PE2R4_RABIT reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 Oryctolagus cuniculus (Rabbit) 488 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624] GO:0004957; GO:0005886; GO:0007188; GO:0016021; GO:0033624; GO:0050728; GO:2000420 0 0 0 PF00001; Q61140 CHOYP_LOC100374152.1.1 m.24548 sp BCAR1_MOUSE 28.9 1000 493 37 8 921 6 873 7.80E-90 308 BCAR1_MOUSE reviewed Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas) Bcar1 Cas Crkas Mus musculus (Mouse) 874 actin filament organization [GO:0007015]; antigen receptor-mediated signaling pathway [GO:0050851]; B cell receptor signaling pathway [GO:0050853]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; epidermal growth factor receptor signaling pathway [GO:0007173]; G-protein coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; insulin receptor signaling pathway [GO:0008286]; integrin-mediated signaling pathway [GO:0007229]; neurotrophin TRK receptor signaling pathway [GO:0048011]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell migration [GO:0030335]; positive regulation of endothelial cell migration [GO:0010595]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001726; GO:0004871; GO:0005730; GO:0005737; GO:0005829; GO:0005886; GO:0005925; GO:0007015; GO:0007155; GO:0007173; GO:0007186; GO:0007229; GO:0008286; GO:0010595; GO:0015629; GO:0016477; GO:0019901; GO:0030027; GO:0030335; GO:0035729; GO:0048008; GO:0048010; GO:0048011; GO:0048012; GO:0050851; GO:0050853; GO:0060326 0 0 0 PF12026;PF08824;PF00018; Q9BE18 CHOYP_LOC101243046.2.2 m.39336 sp MAGE1_MACFA 26.816 358 198 8 174 487 58 395 7.80E-11 69.3 MAGE1_MACFA reviewed Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (MAGE-E1 antigen) MAGEE1 QflA-10248 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 957 0 GO:0005634; GO:0005886; GO:0030425; GO:0045211; GO:0048471 0 0 0 PF01454; Q9DAN9 CHOYP_NEMVEDRAFT_V1G240545.3.3 m.50737 sp CQ105_MOUSE 38.889 126 72 2 15 136 23 147 7.80E-21 87 CQ105_MOUSE reviewed Uncharacterized protein C17orf105 homolog 0 Mus musculus (Mouse) 164 0 0 0 0 0 PF13879; Q9ESN6 CHOYP_LOC100374741.45.83 m.41940 sp TRIM2_MOUSE 29.775 178 107 10 234 404 536 702 7.80E-08 58.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O00370 CHOYP_LOC589519.1.3 m.9377 sp LORF2_HUMAN 26.573 143 104 1 2 144 6 147 7.81E-13 67.8 LORF2_HUMAN reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] 0 Homo sapiens (Human) 1275 "DNA recombination [GO:0006310]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; reverse transcription involved in RNA-mediated transposition [GO:0032199]; transposition, RNA-mediated [GO:0032197]" GO:0003964; GO:0006310; GO:0009036; GO:0032197; GO:0032199; GO:0046872; GO:0090305 0 0 0 PF08333;PF03372;PF00078; P01130 CHOYP_VLDLR.2.2 m.44867 sp LDLR_HUMAN 56 75 31 2 93 166 72 145 7.81E-19 85.9 LDLR_HUMAN reviewed Low-density lipoprotein receptor (LDL receptor) LDLR Homo sapiens (Human) 860 cholesterol homeostasis [GO:0042632]; cholesterol import [GO:0070508]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; endocytosis [GO:0006897]; intestinal cholesterol absorption [GO:0030299]; lipid metabolic process [GO:0006629]; lipoprotein catabolic process [GO:0042159]; low-density lipoprotein particle clearance [GO:0034383]; phospholipid transport [GO:0015914]; positive regulation of triglyceride biosynthetic process [GO:0010867]; receptor-mediated endocytosis [GO:0006898]; regulation of cholesterol homeostasis [GO:2000188]; regulation of phosphatidylcholine catabolic process [GO:0010899] GO:0001618; GO:0001948; GO:0002020; GO:0004872; GO:0005041; GO:0005509; GO:0005764; GO:0005769; GO:0005770; GO:0005794; GO:0005886; GO:0005887; GO:0005905; GO:0006629; GO:0006897; GO:0006898; GO:0008203; GO:0009897; GO:0009986; GO:0010008; GO:0010867; GO:0010899; GO:0015914; GO:0016020; GO:0016323; GO:0030169; GO:0030229; GO:0030299; GO:0030301; GO:0030669; GO:0032050; GO:0034362; GO:0034383; GO:0042159; GO:0042632; GO:0042802; GO:0043235; GO:0045177; GO:0070508; GO:1990666; GO:2000188 0 0 0 PF07645;PF00057;PF00058; Q4R739 CHOYP_ANKRD6.2.2 m.14610 sp ANR53_MACFA 37.209 86 49 1 26 106 130 215 7.81E-09 56.6 ANR53_MACFA reviewed Ankyrin repeat domain-containing protein 53 ANKRD53 QtsA-16406 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 496 cell division [GO:0051301]; mitotic metaphase plate congression [GO:0007080]; positive regulation of microtubule polymerization [GO:0031116]; regulation of mitotic cytokinesis [GO:1902412]; regulation of mitotic spindle organization [GO:0060236] GO:0000922; GO:0005737; GO:0005819; GO:0007080; GO:0031116; GO:0051301; GO:0060236; GO:1902412 0 0 0 PF12796; Q5DU00 CHOYP_LOC100376412.2.3 m.28370 sp DCDC2_MOUSE 29.756 410 233 13 2 397 6 374 7.81E-35 141 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q5UPG5 CHOYP_NEMVEDRAFT_V1G206950.1.1 m.37573 sp YL093_MIMIV 32.5 120 76 3 18 137 304 418 7.81E-13 73.6 YL093_MIMIV reviewed Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) 421 0 0 0 0 0 PF00023;PF12796; Q6R5N8 CHOYP_TLR13.4.5 m.34867 sp TLR13_MOUSE 27.292 960 566 30 8 872 55 977 7.81E-60 224 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q7Z5K2 CHOYP_LOC100376151.1.1 m.21094 sp WAPL_HUMAN 40.108 743 363 14 501 1209 496 1190 7.81E-156 501 WAPL_HUMAN reviewed Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) WAPL FOE KIAA0261 WAPAL Homo sapiens (Human) 1190 cell division [GO:0051301]; meiotic chromosome segregation [GO:0045132]; mitotic sister chromatid cohesion [GO:0007064]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA replication [GO:0008156]; negative regulation of sister chromatid cohesion [GO:0045875]; positive regulation of fibroblast proliferation [GO:0048146]; protein localization to chromatin [GO:0071168]; regulation of chromosome condensation [GO:0060623]; regulation of cohesin loading [GO:0071922]; response to toxic substance [GO:0009636]; sister chromatid cohesion [GO:0007062]; viral process [GO:0016032] GO:0000775; GO:0000785; GO:0000795; GO:0000798; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005829; GO:0007062; GO:0007064; GO:0008156; GO:0008278; GO:0009636; GO:0015630; GO:0016032; GO:0035562; GO:0043231; GO:0045132; GO:0045875; GO:0048146; GO:0051301; GO:0060623; GO:0071168; GO:0071922 0 0 0 PF07814; Q8C8R3 CHOYP_ANK1.4.8 m.35647 sp ANK2_MOUSE 24.74 481 284 16 65 510 55 492 7.81E-24 109 ANK2_MOUSE reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) Ank2 Mus musculus (Mouse) 3898 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; cardiac muscle contraction [GO:0060048]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization [GO:0008104]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of AV node cell action potential [GO:0098904]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cation channel activity [GO:2001257]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of SA node cell action potential [GO:0098907]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; T-tubule organization [GO:0033292] GO:0002027; GO:0005622; GO:0005737; GO:0005856; GO:0005886; GO:0005887; GO:0006874; GO:0008093; GO:0008104; GO:0010628; GO:0010881; GO:0010882; GO:0014069; GO:0014704; GO:0015459; GO:0016324; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043034; GO:0043268; GO:0044325; GO:0045211; GO:0048471; GO:0050821; GO:0051117; GO:0051924; GO:0051928; GO:0055117; GO:0060048; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086014; GO:0086015; GO:0086036; GO:0086066; GO:0086070; GO:0086091; GO:0098904; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001257; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q8NDA2 CHOYP_AAEL_AAEL005599.1.1 m.59841 sp HMCN2_HUMAN 24.434 221 130 5 36 256 515 698 7.81E-09 60.5 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q969X5 CHOYP_ERGI1.1.1 m.9684 sp ERGI1_HUMAN 64.828 290 100 2 1 289 1 289 7.81E-139 396 ERGI1_HUMAN reviewed Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ER-Golgi intermediate compartment 32 kDa protein) (ERGIC-32) ERGIC1 ERGIC32 KIAA1181 HT034 Homo sapiens (Human) 290 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0000139; GO:0005789; GO:0005793; GO:0006888; GO:0016020; GO:0016021; GO:0033116 0 0 0 PF07970; Q9D273 CHOYP_MMAB.1.1 m.2420 sp MMAB_MOUSE 61.78 191 71 1 2 190 44 234 7.81E-84 251 MMAB_MOUSE reviewed "Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial (EC 2.5.1.17) (Cob(I)alamin adenosyltransferase) (Methylmalonic aciduria type B homolog)" Mmab Mus musculus (Mouse) 237 cobalamin biosynthetic process [GO:0009236]; cobalamin metabolic process [GO:0009235] GO:0005524; GO:0005739; GO:0008817; GO:0009235; GO:0009236 "PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7." 0 0 PF01923; B3EWZ5 CHOYP_NEMVEDRAFT_V1G198667.9.15 m.26165 sp MLRP1_ACRMI 30.776 1134 620 46 594 1638 1450 2507 7.82E-107 383 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D3ZHH1 CHOYP_DLL4.1.1 m.40197 sp DLL4_RAT 29.293 396 222 12 21 377 29 405 7.82E-31 131 DLL4_RAT reviewed Delta-like protein 4 (Drosophila Delta homolog 4) (Delta4) Dll4 Rattus norvegicus (Rat) 686 blood vessel lumenization [GO:0072554]; blood vessel remodeling [GO:0001974]; cardiac atrium morphogenesis [GO:0003209]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; dorsal aorta morphogenesis [GO:0035912]; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903588]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling involved in heart development [GO:0061314]; patterning of blood vessels [GO:0001569]; pericardium morphogenesis [GO:0003344]; positive regulation of gene expression [GO:0010628]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of neural retina development [GO:0061074]; regulation of neurogenesis [GO:0050767]; T cell differentiation [GO:0030217]; ventral spinal cord interneuron fate commitment [GO:0060579]; ventricular trabecula myocardium morphogenesis [GO:0003222] GO:0000122; GO:0001569; GO:0001974; GO:0003209; GO:0003222; GO:0003344; GO:0005509; GO:0005886; GO:0010628; GO:0016021; GO:0030217; GO:0035912; GO:0035924; GO:0044344; GO:0045746; GO:0045747; GO:0050767; GO:0060579; GO:0061074; GO:0061314; GO:0072554; GO:0090051; GO:1903588; GO:2000179 0 0 0 PF01414;PF00008;PF12661;PF07657; O96064 CHOYP_MYSP.1.9 m.1097 sp MYSP_MYTGA 61.355 251 69 3 3 252 7 230 7.82E-93 294 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; Q00PJ3 CHOYP_LOC100533351.1.3 m.33324 sp ASZ1_ATEAB 28.571 133 90 2 92 222 96 225 7.82E-09 60.8 ASZ1_ATEAB reviewed "Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein)" ASZ1 GASZ Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) 475 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0007140; GO:0007275; GO:0007283; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:0071546 0 0 0 PF12796;PF07647; Q14676 CHOYP_LOC100489926.3.3 m.46108 sp MDC1_HUMAN 43.415 205 114 1 1464 1666 1877 2081 7.82E-54 212 MDC1_HUMAN reviewed Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1) MDC1 KIAA0170 NFBD1 Homo sapiens (Human) 2089 double-strand break repair via nonhomologous end joining [GO:0006303]; intra-S DNA damage checkpoint [GO:0031573]; protein sumoylation [GO:0016925] GO:0005634; GO:0005654; GO:0005694; GO:0005925; GO:0006303; GO:0008022; GO:0016925; GO:0031573; GO:0070975 0 0 0 PF00498;PF16770; Q4R6I5 CHOYP_LOC578979.1.1 m.10409 sp CLHC1_MACFA 31.323 597 368 8 17 608 12 571 7.82E-92 298 CLHC1_MACFA reviewed Clathrin heavy chain linker domain-containing protein 1 CLHC1 QtsA-17948 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 586 0 0 0 0 0 PF15739; Q62158 CHOYP_LOC100374741.35.83 m.32961 sp TRI27_MOUSE 25.778 225 133 6 42 244 69 281 7.82E-09 60.8 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q6XE24 CHOYP_RBMS3.1.1 m.42660 sp RBMS3_HUMAN 50.676 296 112 8 31 313 55 329 7.82E-87 271 RBMS3_HUMAN reviewed "RNA-binding motif, single-stranded-interacting protein 3" RBMS3 Homo sapiens (Human) 437 positive regulation of translation [GO:0045727] GO:0000166; GO:0003730; GO:0005737; GO:0045727 0 0 0 PF00076; Q8IZQ1 CHOYP_LOC100878788.1.1 m.13649 sp WDFY3_HUMAN 59.494 158 64 0 1 158 268 425 7.82E-55 189 WDFY3_HUMAN reviewed WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy) WDFY3 KIAA0993 Homo sapiens (Human) 3526 aggrephagy [GO:0035973] GO:0003831; GO:0005545; GO:0005635; GO:0005737; GO:0005776; GO:0016234; GO:0016605; GO:0019898; GO:0031965; GO:0035973; GO:0046872; GO:0097635 0 0 cd06071; PF02138;PF15787;PF01363;PF14844; Q9I7U4 CHOYP_LOC100367089.1.4 m.1384 sp TITIN_DROME 30.43 930 536 25 1003 1900 3942 4792 7.82E-107 391 TITIN_DROME reviewed Titin (D-Titin) (Kettin) sls titin CG1915 Drosophila melanogaster (Fruit fly) 18141 cell division [GO:0051301]; locomotion [GO:0040011]; mesoderm development [GO:0007498]; mitotic chromosome condensation [GO:0007076]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; myoblast fusion [GO:0007520]; regulation of hemocyte proliferation [GO:0035206]; sarcomere organization [GO:0045214]; sensory perception of pain [GO:0019233]; sister chromatid cohesion [GO:0007062]; skeletal muscle tissue development [GO:0007519]; somatic muscle development [GO:0007525]; visceral muscle development [GO:0007522] GO:0000794; GO:0003779; GO:0005863; GO:0005875; GO:0007062; GO:0007076; GO:0007498; GO:0007517; GO:0007519; GO:0007520; GO:0007522; GO:0007525; GO:0008307; GO:0016203; GO:0019233; GO:0030017; GO:0030018; GO:0031674; GO:0035206; GO:0040011; GO:0045214; GO:0051301 0 0 0 PF06582;PF00041;PF07679;PF00018; A0A0R4IBK5 CHOYP_LOC100030710.1.4 m.5280 sp R213A_DANRE 29.68 1095 689 25 1 1064 3127 4171 7.83E-133 449 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 D9IQ16 CHOYP_LOC100185953.2.2 m.27830 sp GXN_ACRMI 27.66 282 170 11 57 319 44 310 7.83E-16 82.4 GXN_ACRMI reviewed Galaxin 0 Acropora millepora (Staghorn coral) 338 0 GO:0005576 0 0 0 0 P11369 CHOYP_LOC100536520.1.4 m.14951 sp LORF2_MOUSE 28.606 416 284 6 1 408 485 895 7.83E-44 167 LORF2_MOUSE reviewed LINE-1 retrotransposable element ORF2 protein (ORF2p) (Long interspersed element-1) (L1) (Retrovirus-related Pol polyprotein LINE-1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease (EC 3.1.21.-)] Pol Gm17492 Mus musculus (Mouse) 1281 DNA recombination [GO:0006310] GO:0003964; GO:0004519; GO:0006310; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P26039 CHOYP_TLN1.2.4 m.19748 sp TLN1_MOUSE 60.944 233 83 4 38 267 632 859 7.83E-66 225 TLN1_MOUSE reviewed Talin-1 Tln1 Tln Mus musculus (Mouse) 2541 cell-substrate junction assembly [GO:0007044]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeletal anchoring at plasma membrane [GO:0007016]; platelet aggregation [GO:0070527] GO:0001726; GO:0005178; GO:0005200; GO:0005737; GO:0005815; GO:0005886; GO:0005925; GO:0007016; GO:0007044; GO:0009986; GO:0017166; GO:0030274; GO:0030866; GO:0032587; GO:0070062; GO:0070527 0 0 0 PF16511;PF00373;PF09379;PF01608;PF09141;PF08913; P96576 CHOYP_LOC100691908.1.1 m.3659 sp YDAC_BACSU 26.946 167 111 4 28 194 5 160 7.83E-17 78.2 YDAC_BACSU reviewed Uncharacterized methyltransferase YdaC (EC 2.1.1.-) ydaC BSU04180 Bacillus subtilis (strain 168) 181 0 GO:0008168 0 0 0 0 Q0VDD8 CHOYP_LOC100376274.5.7 m.38329 sp DYH14_HUMAN 25.541 231 151 4 24 252 1570 1781 7.83E-16 81.3 DYH14_HUMAN reviewed "Dynein heavy chain 14, axonemal (Axonemal beta dynein heavy chain 14) (Ciliary dynein heavy chain 14)" DNAH14 C1orf67 Homo sapiens (Human) 3507 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0005929; GO:0007018; GO:0030286 0 0 0 PF12780;PF03028;PF12777; Q4ZJM9 CHOYP_C1QL4.7.10 m.49245 sp C1QL4_MOUSE 35.043 117 63 4 53 168 108 212 7.83E-08 53.9 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q502M6 CHOYP_TVAG_123950.3.31 m.23351 sp ANR29_DANRE 39.487 195 118 0 2 196 35 229 7.83E-45 153 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q75ZY9 CHOYP_BRAFLDRAFT_118213.1.2 m.48349 sp MET_CANLF 22.716 832 518 33 45 800 63 845 7.83E-35 148 MET_CANLF reviewed Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) MET Canis lupus familiaris (Dog) (Canis familiaris) 1382 positive chemotaxis [GO:0050918]; positive regulation of endothelial cell chemotaxis [GO:2001028]; semaphorin-plexin signaling pathway [GO:0071526]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004714; GO:0005524; GO:0007169; GO:0016021; GO:0050918; GO:0071526; GO:2001028 0 0 0 PF07714;PF01437;PF01403;PF01833; Q8TCB0 CHOYP_BRAFLDRAFT_91636.9.11 m.59478 sp IFI44_HUMAN 27.079 469 272 10 31 498 23 422 7.83E-43 160 IFI44_HUMAN reviewed Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) IFI44 MTAP44 Homo sapiens (Human) 444 response to virus [GO:0009615] GO:0005737; GO:0009615 0 0 0 PF07534; P32429 CHOYP_LOC100366813.3.6 m.21331 sp RL7A_CHICK 75.316 158 37 1 2 159 72 227 7.84E-82 245 RL7A_CHICK reviewed 60S ribosomal protein L7a RPL7A SURF-3 Gallus gallus (Chicken) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0005730; GO:0005925; GO:0006412; GO:0016020; GO:0022625; GO:0042788; GO:0044822; GO:0070062 0 0 0 PF01248; Q17427 CHOYP_AGAP_AGAP010769.1.1 m.37851 sp GNA1_CAEEL 47.794 136 68 2 30 165 33 165 7.84E-39 132 GNA1_CAEEL reviewed Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) gna-1 B0024.12 Caenorhabditis elegans 165 UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0004343; GO:0006048 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. 0 0 PF00583; Q2F637 CHOYP_LOC710252.1.1 m.7974 sp 1433Z_BOMMO 70.4 125 37 0 1 125 123 247 7.84E-61 189 1433Z_BOMMO reviewed 14-3-3 protein zeta 14-3-3zeta Bombyx mori (Silk moth) 247 0 GO:0005737 0 0 0 PF00244; Q2KHV4 CHOYP_LOC576709.1.1 m.46516 sp PARL_BOVIN 34.815 270 154 3 106 356 96 362 7.84E-46 163 PARL_BOVIN reviewed "Presenilins-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]" PARL PSARL Bos taurus (Bovine) 377 negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; protein processing [GO:0016485]; regulation of mitophagy [GO:1903146]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of proteolysis [GO:0030162]; regulation of reactive oxygen species metabolic process [GO:2000377] GO:0004252; GO:0005634; GO:0005743; GO:0016021; GO:0016485; GO:0030162; GO:0090201; GO:1903146; GO:1903214; GO:2000377; GO:2001243 0 0 0 PF01694; Q5BIM1 CHOYP_LOC100377788.1.1 m.16176 sp TRI45_BOVIN 24 200 125 7 21 207 135 320 7.84E-07 55.5 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5IS99 CHOYP_CRYZ.2.2 m.65929 sp CASP3_SAIBB 26.882 93 64 1 192 284 188 276 7.84E-06 50.1 CASP3_SAIBB reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 Saimiri boliviensis boliviensis (Bolivian squirrel monkey) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q5RCS0 CHOYP_ATG9A.1.1 m.45030 sp ATG9A_PONAB 48.193 166 76 1 1 166 438 593 7.84E-51 177 ATG9A_PONAB reviewed Autophagy-related protein 9A (APG9-like 1) ATG9A APG9L1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 839 autophagy [GO:0006914]; protein transport [GO:0015031] GO:0000421; GO:0005794; GO:0006914; GO:0015031; GO:0016021; GO:0031410; GO:0031902 0 0 0 PF04109; Q9QXK2 CHOYP_LOC100369548.1.1 m.14165 sp RAD18_MOUSE 39.106 358 194 5 25 372 16 359 7.84E-70 244 RAD18_MOUSE reviewed E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-) (Postreplication repair protein RAD18) (mRAD18Sc) Rad18 Rad18sc Mus musculus (Mouse) 509 cellular response to DNA damage stimulus [GO:0006974]; negative regulation of cell death [GO:0060548]; negative regulation of DNA recombination [GO:0045910]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; response to UV [GO:0009411]; spermatogenesis [GO:0007283] GO:0000403; GO:0000785; GO:0001741; GO:0005634; GO:0005654; GO:0005657; GO:0005737; GO:0005813; GO:0006301; GO:0006513; GO:0006974; GO:0007283; GO:0008270; GO:0009411; GO:0016874; GO:0031593; GO:0031625; GO:0032403; GO:0035861; GO:0042405; GO:0042802; GO:0043142; GO:0045910; GO:0051865; GO:0051984; GO:0060548; GO:0061630; GO:0097505 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02037; Q9UJX3 CHOYP_APC7.1.1 m.55071 sp APC7_HUMAN 42.199 564 309 7 1 552 35 593 7.84E-149 443 APC7_HUMAN reviewed Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) ANAPC7 APC7 Homo sapiens (Human) 599 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439] GO:0005634; GO:0005654; GO:0005680; GO:0005829; GO:0007067; GO:0019903; GO:0031145; GO:0042787; GO:0043161; GO:0051301; GO:0051436; GO:0051437; GO:0051439; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13181; A6QP79 CHOYP_LOC100342125.1.2 m.4800 sp COL12_BOVIN 35.811 148 85 4 21 163 590 732 7.85E-22 94.7 COL12_BOVIN reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) COLEC12 CLP1 Bos taurus (Bovine) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; O70277 CHOYP_BRAFLDRAFT_102380.11.11 m.65248 sp TRIM3_RAT 23.077 247 166 8 7 235 490 730 7.85E-07 52.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P15989 CHOYP_LOC100538313.1.1 m.64152 sp CO6A3_CHICK 23.014 1951 1271 70 1119 3011 38 1815 7.85E-107 389 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P25107 CHOYP_CRHR1.1.1.1 m.4544 sp PTH1R_DIDVI 30.383 418 262 10 41 446 87 487 7.85E-54 192 PTH1R_DIDVI reviewed Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor) PTH1R PTHR PTHR1 Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) 585 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; cell surface receptor signaling pathway [GO:0007166] GO:0004991; GO:0005887; GO:0007166; GO:0007188; GO:0017046; GO:0043621 0 0 0 PF00002;PF02793; P30974 CHOYP_contig_021841 m.25071 sp TLR1_DROME 27.619 210 143 4 13 218 77 281 7.85E-08 57.4 TLR1_DROME reviewed Tachykinin-like peptides receptor 86C (NKD) TkR86C NKD Takr86C CG6515 Drosophila melanogaster (Fruit fly) 504 G-protein coupled receptor signaling pathway [GO:0007186]; inter-male aggressive behavior [GO:0002121]; neuropeptide signaling pathway [GO:0007218]; tachykinin receptor signaling pathway [GO:0007217] GO:0002121; GO:0004995; GO:0005887; GO:0007186; GO:0007217; GO:0007218; GO:0008188; GO:0016021 0 0 0 PF00001; P33431 CHOYP_SODC.1.1 m.11981 sp SODC_CAVPO 46.032 126 66 1 279 404 29 152 7.85E-26 106 SODC_CAVPO reviewed Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) SOD1 Cavia porcellus (Guinea pig) 153 activation of MAPK activity [GO:0000187]; apoptotic DNA fragmentation [GO:0006309]; auditory receptor cell stereocilium organization [GO:0060088]; cell aging [GO:0007569]; cellular iron ion homeostasis [GO:0006879]; double-strand break repair [GO:0006302]; embryo implantation [GO:0007566]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of neuron apoptotic process [GO:0043524]; neurofilament cytoskeleton organization [GO:0060052]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of protein kinase activity [GO:0045859]; relaxation of vascular smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to organic substance [GO:0010033]; response to superoxide [GO:0000303]; retina homeostasis [GO:0001895]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide metabolic process [GO:0006801]; transmission of nerve impulse [GO:0019226] GO:0000187; GO:0000303; GO:0001541; GO:0001819; GO:0001895; GO:0002262; GO:0004784; GO:0005507; GO:0005615; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0006302; GO:0006309; GO:0006749; GO:0006801; GO:0006879; GO:0007283; GO:0007566; GO:0007569; GO:0007605; GO:0007626; GO:0008217; GO:0008270; GO:0009408; GO:0010033; GO:0019226; GO:0019430; GO:0030346; GO:0031012; GO:0031410; GO:0032287; GO:0032839; GO:0040014; GO:0042493; GO:0042542; GO:0043025; GO:0043085; GO:0043234; GO:0043524; GO:0045471; GO:0045541; GO:0045859; GO:0046716; GO:0048678; GO:0050665; GO:0051087; GO:0051881; GO:0060047; GO:0060052; GO:0060087; GO:0060088; GO:0072593 0 0 cd00305; PF00080; Q12955 CHOYP_ISCW_ISCW012164.1.1 m.1290 sp ANK3_HUMAN 28.613 346 183 6 64 408 416 698 7.85E-32 134 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q3UHR0 CHOYP_LOC100369237.2.3 m.42146 sp BAHC1_MOUSE 57.803 173 72 1 1995 2167 2462 2633 7.85E-59 229 BAHC1_MOUSE reviewed BAH and coiled-coil domain-containing protein 1 Bahcc1 Kiaa1447 Mus musculus (Mouse) 2643 chromatin silencing [GO:0006342]; heterochromatin assembly [GO:0031507] GO:0000785; GO:0000976; GO:0003682; GO:0005677; GO:0006342; GO:0031507 0 0 0 PF01426; Q4KMC9 CHOYP_CA198.1.1 m.25778 sp CA198_DANRE 37.037 135 76 4 8 136 21 152 7.85E-19 89.7 CA198_DANRE reviewed Uncharacterized protein C1orf198 homolog wu:fa18f11 Danio rerio (Zebrafish) (Brachydanio rerio) 330 0 0 0 0 0 PF15797; Q8C5L6 CHOYP_LOC101173869.1.1 m.32090 sp INP5K_MOUSE 37.678 422 240 8 13 416 34 450 7.85E-91 285 INP5K_MOUSE reviewed Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Skeletal muscle and kidney-enriched inositol phosphatase) Inpp5k Pps Skip Mus musculus (Mouse) 468 "cellular response to cAMP [GO:0071320]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hormone stimulus [GO:0032870]; cellular response to insulin stimulus [GO:0032869]; cellular response to tumor necrosis factor [GO:0071356]; dephosphorylation [GO:0016311]; glucose homeostasis [GO:0042593]; G-protein coupled receptor signaling pathway [GO:0007186]; inositol phosphate dephosphorylation [GO:0046855]; in utero embryonic development [GO:0001701]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of glucose transport [GO:0010829]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein targeting to membrane [GO:0090315]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of transcription, DNA-templated [GO:0045892]; phosphatidylinositol dephosphorylation [GO:0046856]; positive regulation of renal water transport [GO:2001153]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of urine volume [GO:0035810]; protein targeting to plasma membrane [GO:0072661]; regulation of glycogen biosynthetic process [GO:0005979]; response to insulin [GO:0032868]; ruffle assembly [GO:0097178]" GO:0001701; GO:0001726; GO:0001933; GO:0004445; GO:0005000; GO:0005634; GO:0005737; GO:0005783; GO:0005802; GO:0005829; GO:0005886; GO:0005979; GO:0006469; GO:0007186; GO:0010801; GO:0010829; GO:0016020; GO:0016311; GO:0016312; GO:0032587; GO:0032868; GO:0032869; GO:0032870; GO:0033137; GO:0034485; GO:0034594; GO:0034595; GO:0035305; GO:0035810; GO:0042593; GO:0043005; GO:0043407; GO:0043922; GO:0045719; GO:0045869; GO:0045892; GO:0045893; GO:0046030; GO:0046627; GO:0046855; GO:0046856; GO:0048471; GO:0051497; GO:0051898; GO:0051926; GO:0052658; GO:0052659; GO:0071320; GO:0071356; GO:0071364; GO:0072661; GO:0090315; GO:0097178; GO:2000466; GO:2001153 0 0 0 PF03372; Q9CQM0 CHOYP_LOC100378696.1.1 m.29113 sp NICN1_MOUSE 39.367 221 116 5 8 225 8 213 7.85E-54 174 NICN1_MOUSE reviewed Nicolin-1 (Tubulin polyglutamylase complex subunit 5) (PGs5) (p24) Nicn1 Mus musculus (Mouse) 213 0 GO:0005634; GO:0005874 0 0 0 0 Q9NFP5 CHOYP_LOC101175670.1.1 m.37 sp SH3BG_DROME 45.283 106 50 2 1 99 1 105 7.85E-24 100 SH3BG_DROME reviewed SH3 domain-binding glutamic acid-rich protein homolog (SH3BGR protein) Sh3beta SH3BGR CG8582 Drosophila melanogaster (Fruit fly) 158 0 0 0 0 0 PF04908; O75095 CHOYP_SRP68.1.1 m.61853 sp MEGF6_HUMAN 36.271 295 172 9 27 320 731 1010 7.86E-41 155 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; O88278 CHOYP_LOC100882719.1.1 m.25220 sp CELR3_RAT 30.648 633 384 22 4 619 498 1092 7.86E-57 211 CELR3_RAT reviewed Cadherin EGF LAG seven-pass G-type receptor 3 (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) Celsr3 Megf2 Rattus norvegicus (Rat) 3313 axonal fasciculation [GO:0007413]; cell surface receptor signaling pathway [GO:0007166]; cilium assembly [GO:0042384]; dopaminergic neuron axon guidance [GO:0036514]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of protein phosphorylation [GO:0001932]; serotonergic neuron axon guidance [GO:0036515] GO:0001764; GO:0001932; GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007166; GO:0007413; GO:0016021; GO:0032880; GO:0036514; GO:0036515; GO:0042384 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF02793;PF00053;PF02210; P05450 CHOYP_BRAFLDRAFT_68342.1.2 m.56480 sp YAT7_RHOBL 39.726 73 43 1 90 162 33 104 7.86E-10 56.6 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P68252 CHOYP_1433G.2.2 m.63450 sp 1433G_BOVIN 59.504 242 95 3 1 241 1 240 7.86E-99 291 1433G_BOVIN reviewed "14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]" YWHAG Bos taurus (Bovine) 247 regulation of neuron differentiation [GO:0045664]; regulation of synaptic plasticity [GO:0048167] GO:0005159; GO:0005737; GO:0019904; GO:0045664; GO:0048167 0 0 0 PF00244; P68252 CHOYP_ECD.1.1 m.61799 sp 1433G_BOVIN 59.504 242 95 3 1 241 1 240 7.86E-99 291 1433G_BOVIN reviewed "14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]" YWHAG Bos taurus (Bovine) 247 regulation of neuron differentiation [GO:0045664]; regulation of synaptic plasticity [GO:0048167] GO:0005159; GO:0005737; GO:0019904; GO:0045664; GO:0048167 0 0 0 PF00244; P68252 CHOYP_MYOF.3.3 m.53229 sp 1433G_BOVIN 59.504 242 95 3 1 241 1 240 7.86E-99 291 1433G_BOVIN reviewed "14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]" YWHAG Bos taurus (Bovine) 247 regulation of neuron differentiation [GO:0045664]; regulation of synaptic plasticity [GO:0048167] GO:0005159; GO:0005737; GO:0019904; GO:0045664; GO:0048167 0 0 0 PF00244; Q4R8M9 CHOYP_BRAFLDRAFT_124130.3.3 m.49996 sp GTSF1_MACFA 40.179 112 56 3 45 154 9 111 7.86E-20 88.2 GTSF1_MACFA reviewed Gametocyte-specific factor 1 (Protein FAM112B) GTSF1 FAM112B QtsA-12026 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 167 cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0005737; GO:0007283; GO:0030154; GO:0046872 0 0 0 PF05253; Q6GV12 CHOYP_LOC100337900.1.1 m.10700 sp KDSR_MOUSE 53.165 316 146 2 11 326 13 326 7.86E-123 358 KDSR_MOUSE reviewed 3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1 homolog) (FVT-1) Kdsr Fvt1 Mus musculus (Mouse) 332 3-keto-sphinganine metabolic process [GO:0006666]; sphingolipid biosynthetic process [GO:0030148] GO:0005783; GO:0005789; GO:0006666; GO:0016020; GO:0016021; GO:0030148; GO:0047560 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF00106; Q6ZRF8 CHOYP_LOC100124238.1.2 m.2656 sp RN207_HUMAN 23.469 196 129 7 28 213 99 283 7.86E-11 65.1 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7Z0T3 CHOYP_SMP_137640.1.2 m.40559 sp TEMPT_APLCA 43.59 78 43 1 33 109 18 95 7.86E-12 62.4 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q99MU0 CHOYP_LRRX1.1.11 m.6593 sp DBF4A_CRIGR 26.744 344 186 9 22 349 39 332 7.86E-25 115 DBF4A_CRIGR reviewed Protein DBF4 homolog A (ChDBF4) DBF4 DBF4A Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 676 cell cycle [GO:0007049]; DNA replication [GO:0006260] GO:0003676; GO:0005634; GO:0006260; GO:0007049; GO:0008270 0 0 0 PF07535; Q9C5D2 CHOYP_LOC754350.1.1 m.52184 sp FBL4_ARATH 24.204 628 409 18 5 619 11 584 7.86E-22 103 FBL4_ARATH reviewed F-box/LRR-repeat protein 4 (AtFBL4) FBL4 At4g15475 dl3775w FCAALL.58 Arabidopsis thaliana (Mouse-ear cress) 610 0 0 0 0 0 PF12937;PF13516; Q9IA76 CHOYP_NEMVEDRAFT_V1G235042.1.2 m.30123 sp RL31_PAROL 77.778 90 20 0 1 90 28 117 7.86E-49 154 RL31_PAROL reviewed 60S ribosomal protein L31 rpl31 Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus) 124 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 cd00463; PF01198; Q9JLL3 CHOYP_TNR19.1.2 m.38533 sp TNR19_MOUSE 29.771 131 75 5 14 141 10 126 7.86E-06 47.4 TNR19_MOUSE reviewed Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer) Tnfrsf19 Taj Troy Mus musculus (Mouse) 416 hair follicle development [GO:0001942]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330] GO:0001942; GO:0004872; GO:0005576; GO:0005886; GO:0016021; GO:0043123; GO:0046330 0 0 0 PF00020; Q9P0M2 CHOYP_LOC100176099.1.1 m.40368 sp AKA7G_HUMAN 30.653 199 124 5 9 196 86 281 7.86E-18 83.2 AKA7G_HUMAN reviewed A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) AKAP7 AKAP18 Homo sapiens (Human) 348 0 GO:0000166; GO:0005634; GO:0005829; GO:0051018 0 0 0 PF10469;PF10470; O31463 CHOYP_BRAFLDRAFT_114091.1.3 m.19032 sp HMT_BACSU 42.424 297 159 6 6 295 15 306 7.87E-72 227 HMT_BACSU reviewed Homocysteine S-methyltransferase YbgG (EC 2.1.1.10) (S-methylmethionine:homocysteine methyltransferase) ybgG BSU02410 Bacillus subtilis (strain 168) 315 methionine biosynthetic process [GO:0009086] GO:0008168; GO:0009086; GO:0046872 0 0 0 PF02574; P28824 CHOYP_NRP1.3.5 m.41077 sp NRP1_XENLA 28.435 313 187 15 36 333 27 317 7.87E-17 87.4 NRP1_XENLA reviewed Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) 928 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; endothelial cell chemotaxis [GO:0035767]; organ morphogenesis [GO:0009887]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005021; GO:0007411; GO:0008201; GO:0009887; GO:0016021; GO:0017154; GO:0035767; GO:0046872; GO:0048010 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P34714 CHOYP_LOC100374633.1.2 m.21988 sp SPRC_CAEEL 44.167 240 128 4 104 338 26 264 7.87E-63 204 SPRC_CAEEL reviewed SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) ost-1 sparc C44B12.2 Caenorhabditis elegans 264 multicellular organism development [GO:0007275]; signal transduction [GO:0007165] GO:0005509; GO:0005604; GO:0005615; GO:0007165; GO:0007275 0 0 0 PF09289;PF07648;PF10591; P38117 CHOYP_ISCW_ISCW012010.1.1 m.27251 sp ETFB_HUMAN 68.775 253 79 0 1 253 1 253 7.87E-128 365 ETFB_HUMAN reviewed Electron transfer flavoprotein subunit beta (Beta-ETF) ETFB FP585 Homo sapiens (Human) 255 fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539]; respiratory electron transport chain [GO:0022904] GO:0005739; GO:0005759; GO:0009055; GO:0017133; GO:0022904; GO:0033539; GO:0043231; GO:0070062 0 0 cd01714; PF01012; P41241 CHOYP_LOC100691138.1.1 m.21595 sp CSK_MOUSE 26.842 190 99 7 213 396 292 447 7.87E-09 61.6 CSK_MOUSE reviewed Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase MPK-2) (p50CSK) Csk Mus musculus (Mouse) 450 adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system development [GO:0007417]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of kinase activity [GO:0033673]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of MAP kinase activity [GO:0043406]; protein phosphorylation [GO:0006468]; regulation of cytokine production [GO:0001817]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of T cell activation [GO:0050863]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001817; GO:0002250; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005737; GO:0005886; GO:0005911; GO:0006468; GO:0007169; GO:0007417; GO:0007420; GO:0008285; GO:0010989; GO:0016477; GO:0016740; GO:0030154; GO:0031234; GO:0032715; GO:0033673; GO:0034236; GO:0034332; GO:0035556; GO:0038083; GO:0042802; GO:0042997; GO:0043406; GO:0045087; GO:0045121; GO:0045779; GO:0046872; GO:0048709; GO:0050765; GO:0050863; GO:0060368; GO:0070062; GO:0070373; GO:0071375 0 0 0 PF07714;PF00017;PF00018; P56656 CHOYP_BRAFLDRAFT_57483.1.2 m.7872 sp CP239_MOUSE 37.238 478 284 6 16 484 20 490 7.87E-107 329 CP239_MOUSE reviewed Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39) Cyp2c39 Mus musculus (Mouse) 490 epoxygenase P450 pathway [GO:0019373] GO:0004497; GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0019373; GO:0020037; GO:0031090; GO:0034875; GO:0070330 0 0 0 PF00067; Q04841 CHOYP_LOC100373361.1.1 m.52416 sp 3MG_MOUSE 45.098 255 125 6 6 251 66 314 7.87E-69 218 3MG_MOUSE reviewed DNA-3-methyladenine glycosylase (EC 3.2.2.21) (3-alkyladenine DNA glycosylase) (3-methyladenine DNA glycosidase) (ADPG) (N-methylpurine-DNA glycosylase) Mpg Mid1 Mus musculus (Mouse) 333 base-excision repair [GO:0006284] GO:0003677; GO:0003905; GO:0005634; GO:0006284; GO:0008725; GO:0042645; GO:0043916; GO:0052821; GO:0052822 0 0 cd00540; PF02245; Q0IHF9 CHOYP_LOC584931.1.1 m.34534 sp SARAF_XENLA 44.91 334 144 10 7 331 1 303 7.87E-73 230 SARAF_XENLA reviewed Store-operated calcium entry-associated regulatory factor (SARAF) (SOCE-associated regulatory factor) (Transmembrane protein 66) saraf tmem66 Xenopus laevis (African clawed frog) 303 calcium ion transport [GO:0006816]; regulation of store-operated calcium entry [GO:2001256] GO:0006816; GO:0030176; GO:2001256 0 0 0 PF06682; Q3T906 CHOYP_GNPTA.1.3 m.35745 sp GNPTA_HUMAN 50.316 475 213 6 5 457 2 475 7.87E-164 498 GNPTA_HUMAN reviewed N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (EC 2.7.8.17) (GlcNAc-1-phosphotransferase subunits alpha/beta) (Stealth protein GNPTAB) (UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta) [Cleaved into: N-acetylglucosamine-1-phosphotransferase subunit alpha; N-acetylglucosamine-1-phosphotransferase subunit beta] GNPTAB GNPTA KIAA1208 Homo sapiens (Human) 1256 carbohydrate phosphorylation [GO:0046835]; lysosome organization [GO:0007040]; N-glycan processing to lysosome [GO:0016256]; protein secretion [GO:0009306] GO:0000139; GO:0003976; GO:0005509; GO:0005794; GO:0007040; GO:0009306; GO:0016021; GO:0016256; GO:0046835 0 0 0 PF06464;PF00066;PF17101;PF11380;PF17102;PF17103; Q6PDN3 CHOYP_MYLK.2.4 m.15699 sp MYLK_MOUSE 42.708 96 48 3 43 135 1352 1443 7.87E-14 77.4 MYLK_MOUSE reviewed "Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]" Mylk Mus musculus (Mouse) 1941 aorta smooth muscle tissue morphogenesis [GO:0060414]; bleb assembly [GO:0032060]; cellular hypotonic response [GO:0071476]; cellular response to calcium ion [GO:0071277]; cellular response to drug [GO:0035690]; cellular response to potassium ion [GO:0035865]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cell migration [GO:0030335]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of wound healing [GO:0090303]; smooth muscle contraction [GO:0006939]; tonic smooth muscle contraction [GO:0014820]; xenophagy [GO:0098792] GO:0001725; GO:0002230; GO:0004687; GO:0005524; GO:0005737; GO:0005911; GO:0006939; GO:0014820; GO:0019899; GO:0030027; GO:0030335; GO:0032060; GO:0032154; GO:0035690; GO:0035865; GO:0046872; GO:0051928; GO:0060414; GO:0070062; GO:0071277; GO:0071476; GO:0090303; GO:0098779; GO:0098792 0 0 0 PF00041;PF07679;PF00069; Q9VAI0 CHOYP_LOC100372194.1.1 m.30487 sp GNA1_DROME 33.582 134 76 6 38 162 4 133 7.87E-15 72.4 GNA1_DROME reviewed Probable glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) CG1969 Drosophila melanogaster (Fruit fly) 219 UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0004343; GO:0006048 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. 0 0 PF00583; E1BD59 CHOYP_TRIM2.7.59 m.13523 sp TRI56_BOVIN 24.101 278 172 9 21 274 20 282 7.88E-15 81.6 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O43301 CHOYP_NEMVEDRAFT_V1G212312.1.5 m.32007 sp HS12A_HUMAN 30.534 655 375 13 1 596 41 674 7.88E-92 300 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O75208 CHOYP_LOC100765748.1.1 m.16564 sp COQ9_HUMAN 46.154 221 116 2 109 327 98 317 7.88E-68 218 COQ9_HUMAN reviewed "Ubiquinone biosynthesis protein COQ9, mitochondrial" COQ9 C16orf49 HSPC326 PSEC0129 Homo sapiens (Human) 318 "mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; ubiquinone biosynthetic process [GO:0006744]" GO:0005739; GO:0005743; GO:0006120; GO:0006744; GO:0008289; GO:0042803 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000250|UniProtKB:Q8K1Z0}. 0 0 PF08511; O94903 CHOYP_BRAFLDRAFT_126227.1.1 m.24340 sp PROSC_HUMAN 55.602 241 104 1 42 282 13 250 7.88E-95 286 PROSC_HUMAN reviewed Proline synthase co-transcribed bacterial homolog protein PROSC Homo sapiens (Human) 275 0 GO:0005622; GO:0005737; GO:0005739; GO:0030170; GO:0070062 0 0 0 PF01168; P08043 CHOYP_ZN568.1.1 m.61611 sp ZFP2_MOUSE 43.235 340 184 5 290 629 128 458 7.88E-87 281 ZFP2_MOUSE reviewed Zinc finger protein 2 (Zfp-2) (Protein mKR2) Zfp2 Fnp-2 Mkr2 Zfp-2 Mus musculus (Mouse) 459 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; P31944 CHOYP_LOC580916.1.1 m.34758 sp CASPE_HUMAN 27.426 237 150 6 94 323 20 241 7.88E-21 92.8 CASPE_HUMAN reviewed "Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]" CASP14 Homo sapiens (Human) 242 cornification [GO:0070268]; epidermis development [GO:0008544]; keratinization [GO:0031424] GO:0004197; GO:0005634; GO:0005737; GO:0008544; GO:0031012; GO:0031424; GO:0045095; GO:0070062; GO:0070268; GO:0097153 0 0 0 0 Q503Q1 CHOYP_BRAFLDRAFT_204736.2.2 m.63327 sp MIEAP_DANRE 38.536 519 239 7 21 529 1 449 7.88E-123 374 MIEAP_DANRE reviewed Mitochondria-eating protein (Spermatogenesis-associated protein 18) spata18 mieap si:ch73-16a12.2 zgc:110352 Danio rerio (Zebrafish) (Brachydanio rerio) 490 cellular response to DNA damage stimulus [GO:0006974]; mitochondrial protein catabolic process [GO:0035694]; mitophagy by induced vacuole formation [GO:0035695] GO:0005737; GO:0005741; GO:0006974; GO:0035694; GO:0035695; GO:0043231 0 0 0 PF16026; Q5VU97 CHOYP_BRAFLDRAFT_103410.1.1 m.57490 sp CAHD1_HUMAN 25.666 413 270 14 2 388 727 1128 7.88E-27 117 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q5ZJ39 CHOYP_PHUM_PHUM319040.1.1 m.54919 sp DENR_CHICK 53.631 179 73 3 34 202 20 198 7.88E-62 193 DENR_CHICK reviewed Density-regulated protein (DRP) DENR RCJMB04_20p1 Gallus gallus (Chicken) 198 formation of translation preinitiation complex [GO:0001731]; IRES-dependent translational initiation [GO:0002192]; ribosome disassembly [GO:0032790] GO:0001731; GO:0002192; GO:0003743; GO:0032790 0 0 0 PF01253; Q8R164 CHOYP_BPHL.1.1 m.55822 sp BPHL_MOUSE 52.549 255 121 0 56 310 37 291 7.88E-100 298 BPHL_MOUSE reviewed Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) Bphl Mus musculus (Mouse) 291 cellular amino acid metabolic process [GO:0006520] GO:0005739; GO:0006520; GO:0016787; GO:0070062 0 0 0 PF00561; Q921D4 CHOYP_BRAFLDRAFT_202253.1.1 m.38923 sp MED6_MOUSE 57.613 243 94 2 1 235 4 245 7.88E-94 278 MED6_MOUSE reviewed Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6) Med6 Mus musculus (Mouse) 246 positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; RNA polymerase II transcriptional preinitiation complex assembly [GO:0051123]; stem cell population maintenance [GO:0019827] GO:0001128; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0006357; GO:0008134; GO:0016020; GO:0016592; GO:0019827; GO:0045944; GO:0051123; GO:0070847 0 0 0 PF04934; Q96II8 CHOYP_LRCH3.2.4 m.37929 sp LRCH3_HUMAN 54.661 236 106 1 12 247 44 278 7.88E-73 259 LRCH3_HUMAN reviewed Leucine-rich repeat and calponin homology domain-containing protein 3 LRCH3 Homo sapiens (Human) 777 0 GO:0005576; GO:0005737 0 0 0 PF00307;PF13855; Q9C040 CHOYP_BRAFLDRAFT_87322.6.10 m.46284 sp TRIM2_HUMAN 22.449 147 108 3 139 285 483 623 7.88E-06 50.8 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9VN14 CHOYP_LOC100902807.3.4 m.49112 sp CONT_DROME 35.714 84 51 2 8 88 1272 1355 7.88E-10 58.5 CONT_DROME reviewed Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) 1390 axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nerve maturation [GO:0021682]; septate junction assembly [GO:0019991] GO:0005886; GO:0005918; GO:0008366; GO:0019991; GO:0021682; GO:0031225; GO:0045197; GO:0060857; GO:0061343 0 0 0 PF00041;PF00047;PF00059; P23708 CHOYP_NFYA.1.2 m.18373 sp NFYA_MOUSE 67.949 78 22 2 163 238 246 322 7.89E-27 110 NFYA_MOUSE reviewed Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) Nfya Mus musculus (Mouse) 346 "positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription, DNA-templated [GO:0006355]; rhythmic process [GO:0048511]" GO:0000978; GO:0001046; GO:0001077; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0016602; GO:0032993; GO:0045893; GO:0045944; GO:0048511; GO:2000036; GO:2000648 0 0 0 PF02045; P42700 CHOYP_RO60.3.6 m.31511 sp RO60_XENLA 40.395 557 296 13 20 569 6 533 7.89E-119 365 RO60_XENLA reviewed 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (TROVE domain family member 2) trove2 Xenopus laevis (African clawed frog) 538 cell projection organization [GO:0030030] GO:0005737; GO:0030030; GO:0030529; GO:0034336; GO:0046872 0 0 0 PF05731; Q09575 CHOYP_LOC100892528.1.1 m.709 sp YRD6_CAEEL 35.294 68 43 1 90 157 416 482 7.89E-06 48.1 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q3TX51 CHOYP_LOC100890667.1.1 m.62320 sp LRC28_MOUSE 33.766 385 203 7 58 436 22 360 7.89E-46 166 LRC28_MOUSE reviewed Leucine-rich repeat-containing protein 28 Lrrc28 Mus musculus (Mouse) 367 0 0 0 0 0 PF13855; Q495X7 CHOYP_contig_025064 m.28511 sp TRI60_HUMAN 23.322 283 154 10 10 268 115 358 7.89E-06 51.2 TRI60_HUMAN reviewed Tripartite motif-containing protein 60 (RING finger protein 129) (RING finger protein 33) TRIM60 RNF129 RNF33 Homo sapiens (Human) 471 0 GO:0005622; GO:0008270 0 0 0 PF13765;PF00622;PF00643; Q7Z0T3 CHOYP_PRB2.2.2 m.41331 sp TEMPT_APLCA 41.667 120 51 6 23 136 12 118 7.89E-18 82 TEMPT_APLCA reviewed Temptin 0 Aplysia californica (California sea hare) 125 0 GO:0005576 0 0 0 0 Q86U38 CHOYP_LOC575478.1.1 m.6923 sp NOP9_HUMAN 27.592 598 394 11 31 595 44 635 7.89E-55 200 NOP9_HUMAN reviewed Nucleolar protein 9 NOP9 C14orf21 KIAA2021 Homo sapiens (Human) 636 0 GO:0044822 0 0 0 0 Q8NB90 CHOYP_SPATA5.1.1 m.44522 sp SPAT5_HUMAN 54.054 111 51 0 1 111 783 893 7.89E-38 137 SPAT5_HUMAN reviewed Spermatogenesis-associated protein 5 (ATPase family protein 2 homolog) (Spermatogenesis-associated factor protein) SPATA5 AFG2 SPAF Homo sapiens (Human) 893 brain development [GO:0007420]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283] GO:0005524; GO:0005737; GO:0005739; GO:0007283; GO:0007420; GO:0030154 0 0 0 PF00004; Q91974 CHOYP_LOC100313676.2.2 m.38456 sp IKBA_CHICK 37.143 210 126 3 115 324 77 280 7.89E-35 132 IKBA_CHICK reviewed NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (REL-associated protein pp40) NFKBIA IKBA Gallus gallus (Chicken) 318 regulation of fibroblast proliferation [GO:0048145] GO:0005737; GO:0048145 0 0 0 PF00023;PF12796; Q96BD8 CHOYP_SKA1.1.1 m.12596 sp SKA1_HUMAN 34.058 276 156 4 1 273 1 253 7.89E-44 152 SKA1_HUMAN reviewed Spindle and kinetochore-associated protein 1 SKA1 C18orf24 Homo sapiens (Human) 255 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; regulation of microtubule polymerization or depolymerization [GO:0031110]; sister chromatid cohesion [GO:0007062] GO:0000940; GO:0005829; GO:0005876; GO:0007059; GO:0007062; GO:0007067; GO:0008017; GO:0031110; GO:0051301 0 0 0 PF07160; Q9CZX2 CHOYP_CEP89.2.2 m.30028 sp CEP89_MOUSE 35.622 539 311 6 273 791 220 742 7.89E-89 301 CEP89_MOUSE reviewed Centrosomal protein of 89 kDa (Cep89) (Coiled-coil domain-containing protein 123) Cep89 Ccdc123 Mus musculus (Mouse) 791 chemical synaptic transmission [GO:0007268]; cilium assembly [GO:0042384]; mitochondrion organization [GO:0007005]; nonmotile primary cilium assembly [GO:0035058] GO:0000922; GO:0005737; GO:0005758; GO:0005813; GO:0005814; GO:0005829; GO:0005886; GO:0007005; GO:0007268; GO:0031513; GO:0031514; GO:0035058; GO:0042384; GO:0097539 0 0 0 0 Q9DFQ7 CHOYP_RL24.2.9 m.2264 sp RL24_GILMI 76.768 99 23 0 1 99 23 121 7.89E-49 155 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; Q9H3S7 CHOYP_LOC100866004.1.1 m.41323 sp PTN23_HUMAN 40.432 324 180 3 127 444 1191 1507 7.89E-80 278 PTN23_HUMAN reviewed Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) PTPN23 KIAA1471 Homo sapiens (Human) 1636 cilium morphogenesis [GO:0060271]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162] GO:0004725; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0010633; GO:0015031; GO:0016023; GO:0019901; GO:0036064; GO:0043162; GO:0060271; GO:0070062; GO:1903387; GO:1903393; GO:2000643 0 0 0 PF13949;PF03097;PF00102; Q9NY47 CHOYP_CA2D2.1.2 m.6918 sp CA2D2_HUMAN 42.746 386 186 11 3 372 140 506 7.89E-86 285 CA2D2_HUMAN reviewed Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2] CACNA2D2 KIAA0558 Homo sapiens (Human) 1150 cardiac conduction [GO:0061337]; muscle fiber development [GO:0048747]; neuromuscular junction development [GO:0007528]; positive regulation of organ growth [GO:0046622]; regulation of insulin secretion [GO:0050796]; regulation of multicellular organism growth [GO:0040014]; rhythmic synaptic transmission [GO:0060024] GO:0005245; GO:0005886; GO:0005891; GO:0007528; GO:0040014; GO:0046622; GO:0046872; GO:0048747; GO:0050796; GO:0060024; GO:0061337 0 0 0 PF08473;PF00092;PF08399; Q9NYQ7 CHOYP_LOC100204612.2.2 m.48735 sp CELR3_HUMAN 23.535 973 588 43 189 1063 602 1516 7.89E-35 149 CELR3_HUMAN reviewed Cadherin EGF LAG seven-pass G-type receptor 3 (Cadherin family member 11) (Epidermal growth factor-like protein 1) (EGF-like protein 1) (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains protein 2) (Multiple EGF-like domains protein 2) CELSR3 CDHF11 EGFL1 FMI1 KIAA0812 MEGF2 Homo sapiens (Human) 3312 "axonal fasciculation [GO:0007413]; cilium assembly [GO:0042384]; dopaminergic neuron axon guidance [GO:0036514]; G-protein coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neuron migration [GO:0001764]; regulation of protein localization [GO:0032880]; regulation of protein phosphorylation [GO:0001932]; serotonergic neuron axon guidance [GO:0036515]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0001764; GO:0001932; GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007186; GO:0007413; GO:0016021; GO:0032880; GO:0036514; GO:0036515; GO:0042384; GO:0060071 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9U221 CHOYP_BRAFLDRAFT_287444.1.5 m.680 sp UNG_CAEEL 54.222 225 100 2 62 285 57 279 7.89E-87 263 UNG_CAEEL reviewed Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) ung-1 Y56A3A.29 Caenorhabditis elegans 282 base-excision repair [GO:0006284] GO:0004844; GO:0005634; GO:0005739; GO:0006284 0 0 cd10027; PF03167; P02594 CHOYP_CALM.37.50 m.52385 sp CALM_ELEEL 78.289 152 30 1 1 152 1 149 7.90E-81 238 CALM_ELEEL reviewed Calmodulin (CaM) calm Electrophorus electricus (Electric eel) (Gymnotus electricus) 149 0 GO:0005509 0 0 0 PF13499; P15253 CHOYP_LOC100203010.1.1 m.20036 sp CALR_RABIT 66.667 354 115 3 13 365 15 366 7.90E-175 498 CALR_RABIT reviewed Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) CALR Oryctolagus cuniculus (Rabbit) 418 protein folding [GO:0006457]; protein stabilization [GO:0050821] GO:0005509; GO:0006457; GO:0030246; GO:0033018; GO:0050821 0 0 0 PF00262; P16257 CHOYP_LOC101165869.1.1 m.5175 sp TSPO_RAT 43.478 161 90 1 14 173 2 162 7.90E-45 148 TSPO_RAT reviewed Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR) Tspo Bzrp Mbr Rattus norvegicus (Rat) 169 adrenal gland development [GO:0030325]; aging [GO:0007568]; behavioral response to pain [GO:0048266]; cellular hypotonic response [GO:0071476]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; contact inhibition [GO:0060242]; establishment of protein localization to mitochondrion [GO:0072655]; glial cell migration [GO:0008347]; ion transport [GO:0006811]; lipid transport [GO:0006869]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of mitophagy [GO:1903147]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tumor necrosis factor production [GO:0032720]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of necrotic cell death [GO:0010940]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of steroid biosynthetic process [GO:0050810]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to manganese ion [GO:0010042]; response to pain [GO:0048265]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to vitamin B1 [GO:0010266]; steroid biosynthetic process [GO:0006694] GO:0005497; GO:0005739; GO:0005741; GO:0006694; GO:0006811; GO:0006821; GO:0006869; GO:0007568; GO:0008347; GO:0008503; GO:0010042; GO:0010266; GO:0010940; GO:0014012; GO:0016021; GO:0030325; GO:0031397; GO:0031965; GO:0032570; GO:0032720; GO:0033574; GO:0042493; GO:0043065; GO:0045019; GO:0048265; GO:0048266; GO:0048678; GO:0050810; GO:0051901; GO:0051928; GO:0060242; GO:0060252; GO:0060253; GO:0070062; GO:0071222; GO:0071294; GO:0071476; GO:0072655; GO:0072656; GO:1903147; GO:1903579; GO:2000379 0 0 0 PF03073; P41115 CHOYP_RPS11.4.5 m.57512 sp RS11_XENLA 74.286 105 25 2 13 115 1 105 7.90E-50 159 RS11_XENLA reviewed 40S ribosomal protein S11 rps11 Xenopus laevis (African clawed frog) 158 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00366;PF16205; P79152 CHOYP_LOC101158441.1.1 m.54167 sp CP3AJ_CAPHE 41.546 207 118 3 64 270 5 208 7.90E-57 184 CP3AJ_CAPHE reviewed Cytochrome P450 3A19 (EC 1.14.14.1) (CYPIIIA19) (Fragment) CYP3A19 Capra hircus aegagrus (Wild goat) (Capra aegagrus) 218 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q5M856 CHOYP_RB18B.1.1 m.14958 sp SPC25_RAT 32.593 135 91 0 104 238 87 221 7.90E-22 93.2 SPC25_RAT reviewed Kinetochore protein Spc25 Spc25 Spbc25 Rattus norvegicus (Rat) 226 cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052] GO:0000777; GO:0005634; GO:0007052; GO:0007059; GO:0007067; GO:0031262; GO:0051301 0 0 0 PF08234; Q68EZ3 CHOYP_BRAFLDRAFT_215283.1.1 m.1467 sp ANM6_XENLA 50.154 325 159 2 35 356 14 338 7.90E-117 345 ANM6_XENLA reviewed Protein arginine N-methyltransferase 6 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT6) prmt6 Xenopus laevis (African clawed frog) 340 "DNA repair [GO:0006281]; histone H3-R2 methylation [GO:0034970]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006281; GO:0006351; GO:0019919; GO:0034970; GO:0035241; GO:0035242; GO:0042054; GO:0042393; GO:0044020; GO:0045892; GO:0070611; GO:0070612 0 0 0 PF05185; Q8WZ42 CHOYP_LOC100375089.1.1 m.1345 sp TITIN_HUMAN 34.884 86 53 1 11 96 14916 14998 7.90E-09 55.5 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q99M80 CHOYP_PTPRT.23.45 m.47626 sp PTPRT_MOUSE 33.645 535 328 14 11 527 886 1411 7.90E-75 261 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BX66 CHOYP_LOC100867381.1.8 m.2154 sp SRBS1_HUMAN 31.232 714 346 30 979 1617 286 929 7.90E-54 211 SRBS1_HUMAN reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) 1292 cell-matrix adhesion [GO:0007160]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; muscle contraction [GO:0006936]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0003779; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005913; GO:0005915; GO:0005924; GO:0005925; GO:0006936; GO:0007160; GO:0008092; GO:0008286; GO:0015758; GO:0016363; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q9I8C7 CHOYP_NACHRA4.1.1 m.22655 sp ACH10_CHICK 32.42 219 142 3 1 218 138 351 7.90E-36 139 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9R1R2 CHOYP_PKH_010840.1.3 m.20509 sp TRIM3_MOUSE 25.325 154 108 3 41 190 593 743 7.90E-09 58.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UBX3 CHOYP_K11G12.5.1.1 m.55605 sp DIC_HUMAN 64.029 278 98 2 7 283 6 282 7.90E-130 373 DIC_HUMAN reviewed Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10) SLC25A10 DIC Homo sapiens (Human) 287 "dicarboxylic acid transport [GO:0006835]; gluconeogenesis [GO:0006094]; ion transport [GO:0006811]; mitochondrial transport [GO:0006839]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]; translation [GO:0006412]" GO:0003735; GO:0005310; GO:0005634; GO:0005743; GO:0006094; GO:0006412; GO:0006811; GO:0006835; GO:0006839; GO:0016021; GO:0070221 0 0 0 PF00153; Q9Y2B1 CHOYP_BRAFLDRAFT_66489.1.1 m.59451 sp TMEM5_HUMAN 40.716 447 239 7 1 430 1 438 7.90E-112 338 TMEM5_HUMAN reviewed Transmembrane protein 5 TMEM5 Homo sapiens (Human) 443 protein O-linked mannosylation [GO:0035269] GO:0000139; GO:0005794; GO:0005887; GO:0035269 PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:25279699}. 0 0 PF03016; A2A3L6 CHOYP_BRAFLDRAFT_71030.1.1 m.31477 sp TTC24_HUMAN 33.943 383 236 9 14 391 36 406 7.91E-53 197 TTC24_HUMAN reviewed Tetratricopeptide repeat protein 24 (TPR repeat protein 24) TTC24 Homo sapiens (Human) 582 0 0 0 0 0 PF13176; B0FYY4 CHOYP_CRE-PAT-3.1.1 m.17551 sp ITB1_SHEEP 39.881 168 88 3 38 195 24 188 7.91E-29 115 ITB1_SHEEP reviewed Integrin beta-1 (Fibronectin receptor subunit beta) (Integrin subunit beta-1) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Ovis aries (Sheep) 798 cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; integrin-mediated signaling pathway [GO:0007229]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; receptor internalization [GO:0031623]; regulation of collagen catabolic process [GO:0010710] GO:0004872; GO:0005925; GO:0007160; GO:0007229; GO:0008305; GO:0009986; GO:0010710; GO:0016020; GO:0030027; GO:0031623; GO:0032587; GO:0033627; GO:0042470; GO:0046872; GO:0046982; GO:0055037; GO:0071404; GO:0071438; GO:0090004 0 0 0 PF07974;PF08725;PF07965;PF00362; G5EFI8 CHOYP_LOC100168206.2.3 m.13355 sp PLCE1_CAEEL 40.571 350 202 4 115 459 51 399 7.91E-82 279 PLCE1_CAEEL reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-epsilon plc-1) (Phosphoinositide-specific phospholipase PLC210) (Phospholipase C-epsilon plc-1) (PLC-epsilon plc-1)" plc-1 F31B12.1 Caenorhabditis elegans 1898 "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process [GO:1902634]; negative regulation of adenylate cyclase activity [GO:0007194]; small GTPase mediated signal transduction [GO:0007264]" GO:0004435; GO:0004871; GO:0005085; GO:0005622; GO:0007194; GO:0007264; GO:0017016; GO:1902634 0 0 0 PF00168;PF09279;PF00388;PF00387;PF00788;PF00617; O22703 CHOYP_ISCW_ISCW013289.2.2 m.18741 sp RZ1B_ARATH 35.577 104 56 2 26 118 29 132 7.91E-13 69.7 RZ1B_ARATH reviewed Glycine-rich RNA-binding protein RZ1B (AtRZ-1a) RZ1B At1g60650 F8A5.17 Arabidopsis thaliana (Mouse-ear cress) 292 response to cold [GO:0009409]; response to water deprivation [GO:0009414] GO:0000166; GO:0003676; GO:0003677; GO:0003723; GO:0005634; GO:0008270; GO:0009409; GO:0009414 0 0 0 PF00076;PF00098; O43301 CHOYP_BRAFLDRAFT_208436.21.32 m.58960 sp HS12A_HUMAN 28.875 329 225 5 4 323 305 633 7.91E-50 179 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O70244 CHOYP_LOC100705265.2.3 m.29622 sp CUBN_RAT 28.296 622 377 22 34 614 1617 2210 7.91E-54 205 CUBN_RAT reviewed Cubilin (460 kDa receptor) (Glycoprotein 280) (gp280) (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) Cubn Ifcr Rattus norvegicus (Rat) 3623 cholesterol metabolic process [GO:0008203]; cobalamin transport [GO:0015889]; hemoglobin import [GO:0020028]; in utero embryonic development [GO:0001701]; protein homotrimerization [GO:0070207]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; response to nutrient [GO:0007584]; vitamin metabolic process [GO:0006766] GO:0001701; GO:0004872; GO:0005509; GO:0005765; GO:0005905; GO:0006766; GO:0006898; GO:0007584; GO:0008203; GO:0010008; GO:0015031; GO:0015235; GO:0015889; GO:0016020; GO:0020028; GO:0030135; GO:0030492; GO:0030666; GO:0031419; GO:0031526; GO:0042802; GO:0043202; GO:0043234; GO:0070207 0 0 0 PF00431;PF00008;PF12947;PF07645; O75095 CHOYP_LOC101072623.4.4 m.35077 sp MEGF6_HUMAN 38.889 72 41 3 28 97 875 945 7.91E-06 50.8 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P02637 CHOYP_SCP.2.12 m.26021 sp SCP_MIZYE 35.359 181 103 7 2 180 2 170 7.91E-25 98.2 SCP_MIZYE reviewed Sarcoplasmic calcium-binding protein (SCP) 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 176 0 GO:0005509 0 0 0 0 P10079 CHOYP_LOC100632098.11.13 m.51848 sp FBP1_STRPU 51.554 386 187 0 21 406 178 563 7.91E-122 408 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P55918 CHOYP_LOC100641854.1.2 m.54538 sp MFAP4_BOVIN 42.857 196 97 5 108 298 37 222 7.91E-40 143 MFAP4_BOVIN reviewed Microfibril-associated glycoprotein 4 (36 kDa microfibril-associated glycoprotein) (36 kDa MAP) MFAP4 Bos taurus (Bovine) 255 cell adhesion [GO:0007155]; cellular response to UV-B [GO:0071493]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; regulation of collagen metabolic process [GO:0010712]; UV protection [GO:0009650] GO:0001527; GO:0007155; GO:0009650; GO:0010712; GO:0031012; GO:0043206; GO:0048251; GO:0070062; GO:0071493; GO:0071953 0 0 0 PF00147; Q13310 CHOYP_LOC100741783.1.1 m.10158 sp PABP4_HUMAN 58.702 339 118 6 2 331 175 500 7.91E-124 376 PABP4_HUMAN reviewed Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP) PABPC4 APP1 PABP4 Homo sapiens (Human) 644 blood coagulation [GO:0007596]; RNA catabolic process [GO:0006401]; RNA processing [GO:0006396]; translation [GO:0006412] GO:0000166; GO:0005634; GO:0005737; GO:0006396; GO:0006401; GO:0006412; GO:0007596; GO:0008143; GO:0008266; GO:0010494; GO:0030529; GO:0044822 0 0 0 PF00658;PF00076; Q5K651 CHOYP_SAMD9.1.1 m.14620 sp SAMD9_HUMAN 30.818 318 192 9 3 315 213 507 7.91E-32 129 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q5XGD9 CHOYP_ARID3A.1.1 m.55743 sp ARI3A_XENTR 47.645 361 113 10 170 512 197 499 7.91E-82 267 ARI3A_XENTR reviewed AT-rich interactive domain-containing protein 3A (ARID domain-containing protein 3A) (Bright homolog) (Dead ringer-like protein 1) arid3a dril1 TNeu118e10.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 541 multicellular organism development [GO:0007275] GO:0000977; GO:0001228; GO:0005634; GO:0005737; GO:0007275 0 0 0 PF01388; Q8K4Q8 CHOYP_LOC100373483.1.1 m.38025 sp COL12_MOUSE 29.008 131 77 6 72 194 610 732 7.91E-10 60.8 COL12_MOUSE reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) (Scavenger receptor with C-type lectin) Colec12 Clp1 Srcl Mus musculus (Mouse) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; Q96WV6 CHOYP_contig_002261 m.2462 sp YHU2_SCHPO 33.442 308 187 8 74 368 1676 1978 7.91E-06 52.4 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q9H5V9 CHOYP_PHUM_PHUM454190.1.1 m.65766 sp CX056_HUMAN 65.297 219 65 8 137 345 1 218 7.91E-84 256 CX056_HUMAN reviewed UPF0428 protein CXorf56 CXorf56 Homo sapiens (Human) 222 0 0 0 0 0 0 P16157 CHOYP_LOC579631.3.4 m.33793 sp ANK1_HUMAN 29.888 445 289 5 312 756 139 560 7.92E-52 199 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18142 CHOYP_LOC100375314.1.1 m.19446 sp D2_DICDI 37.58 471 280 9 25 492 33 492 7.92E-95 301 D2_DICDI reviewed cAMP-regulated D2 protein D2 DDB_G0283085 Dictyostelium discoideum (Slime mold) 535 0 GO:0033118; GO:0052689 0 0 0 PF00135; P59222 CHOYP_MEG10.12.91 m.21607 sp SREC2_MOUSE 37.931 116 58 3 184 286 254 368 7.92E-13 72 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; P83425 CHOYP_LOC659383.2.2 m.60367 sp HIP_MYTED 30.769 130 84 3 83 208 85 212 7.92E-08 53.9 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q05516 CHOYP_LOC100576261.1.1 m.16519 sp ZBT16_HUMAN 25.698 179 108 6 30 197 428 592 7.92E-08 60.1 ZBT16_HUMAN reviewed Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF) ZBTB16 PLZF ZNF145 Homo sapiens (Human) 673 "anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cartilage development [GO:0051216]; central nervous system development [GO:0007417]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic pattern specification [GO:0009880]; forelimb morphogenesis [GO:0035136]; hemopoiesis [GO:0030097]; male germ-line stem cell asymmetric division [GO:0048133]; mesonephros development [GO:0001823]; myeloid cell differentiation [GO:0030099]; negative regulation of cell proliferation [GO:0008285]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of ossification [GO:0045778]; positive regulation of transcription, DNA-templated [GO:0045893]; protein localization to nucleus [GO:0034504]; protein ubiquitination [GO:0016567]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000980; GO:0001206; GO:0001823; GO:0003677; GO:0005634; GO:0005730; GO:0005829; GO:0005886; GO:0006351; GO:0006915; GO:0007417; GO:0008285; GO:0009880; GO:0009952; GO:0016567; GO:0016604; GO:0016605; GO:0016607; GO:0017053; GO:0030097; GO:0030099; GO:0032332; GO:0034504; GO:0035116; GO:0035136; GO:0042733; GO:0042802; GO:0042803; GO:0043065; GO:0045600; GO:0045638; GO:0045778; GO:0045892; GO:0045893; GO:0046872; GO:0048133; GO:0051138; GO:0051216; GO:0061036 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00651;PF13912; Q27218 CHOYP_LOC100892811.1.2 m.15425 sp ACH7_CAEEL 30.818 318 207 7 33 343 27 338 7.92E-41 152 ACH7_CAEEL reviewed Acetylcholine receptor subunit beta-type lev-1 (Levamisole-resistant protein 1) lev-1 F09E8.7 Caenorhabditis elegans 507 "inorganic cation transmembrane transport [GO:0098662]; neuromuscular synaptic transmission [GO:0007274]; regulation of locomotion [GO:0040012]; regulation of oviposition [GO:0046662]; response to nicotine [GO:0035094]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0040012; GO:0043005; GO:0043025; GO:0045211; GO:0046662; GO:0098662 0 0 0 PF02931;PF02932; Q2KIB9 CHOYP_LOC100374685.1.1 m.16059 sp RPP29_BOVIN 39.545 220 111 6 2 212 9 215 7.92E-40 139 RPP29_BOVIN reviewed Ribonuclease P protein subunit p29 (EC 3.1.26.5) POP4 RPP29 Bos taurus (Bovine) 220 mRNA cleavage [GO:0006379]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] GO:0000172; GO:0004526; GO:0005655; GO:0006364; GO:0006379; GO:0008033; GO:0030677; GO:0033204 0 0 0 PF01868; Q52KI8 CHOYP_SRRM1.1.3 m.119 sp SRRM1_MOUSE 59.551 89 33 2 13 101 75 160 7.92E-25 105 SRRM1_MOUSE reviewed Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101) Srrm1 Pop101 Mus musculus (Mouse) 946 "mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]" GO:0000375; GO:0000398; GO:0003677; GO:0005681; GO:0016363; GO:0016607 0 0 0 PF01480; Q5K651 CHOYP_LOC100368251.6.6 m.66589 sp SAMD9_HUMAN 33.333 189 109 6 673 858 182 356 7.92E-20 99.4 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q5R4U0 CHOYP_CAH10.2.2 m.35979 sp CAH10_PONAB 41.281 281 151 6 26 294 32 310 7.92E-70 223 CAH10_PONAB reviewed Carbonic anhydrase-related protein 10 CA10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 328 0 0 0 0 0 PF00194; Q8IYJ2 CHOYP_BRAFLDRAFT_129914.3.3 m.63763 sp CJ067_HUMAN 33.898 118 78 0 50 167 70 187 7.92E-17 87.8 CJ067_HUMAN reviewed "Uncharacterized protein C10orf67, mitochondrial" C10orf67 LINC01552 Homo sapiens (Human) 551 0 GO:0005739 0 0 0 PF15821;PF15852; Q9ESN6 CHOYP_BRAFLDRAFT_75885.2.7 m.32753 sp TRIM2_MOUSE 27.586 203 134 6 183 379 536 731 7.92E-14 76.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9JJZ6 CHOYP_KLF13.1.1 m.64376 sp KLF13_MOUSE 73.737 99 25 1 200 298 163 260 7.92E-48 165 KLF13_MOUSE reviewed Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Erythroid transcription factor FKLF-2) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3) Klf13 Bteb3 Fklf2 Mus musculus (Mouse) 289 negative regulation of cell proliferation [GO:0008285]; negative regulation of erythrocyte differentiation [GO:0045647]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000978; GO:0001077; GO:0003677; GO:0005634; GO:0006357; GO:0006366; GO:0008285; GO:0045647; GO:0045944; GO:0046872 0 0 0 0 Q9Y6R7 CHOYP_BRAFLDRAFT_122634.1.2 m.30096 sp FCGBP_HUMAN 21.719 442 315 11 28 461 34 452 7.92E-17 87.8 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; O01761 CHOYP_ISCW_ISCW022096.1.2 m.8858 sp UNC89_CAEEL 25.506 247 152 10 182 412 3187 3417 7.93E-06 52.4 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O16025 CHOYP_NEMVEDRAFT_V1G229180.1.1 m.33920 sp AOSL_PLEHO 31.677 161 99 6 10 164 374 529 7.93E-13 68.9 AOSL_PLEHO reviewed Allene oxide synthase-lipoxygenase protein [Includes: Allene oxide synthase (EC 4.2.1.92) (Hydroperoxidehydrase); Arachidonate 8-lipoxygenase (EC 1.13.11.40)] 0 Plexaura homomalla (Black sea rod) 1066 arachidonic acid metabolic process [GO:0019369]; fatty acid biosynthetic process [GO:0006633]; oxylipin biosynthetic process [GO:0031408] GO:0004096; GO:0005506; GO:0005737; GO:0006633; GO:0016020; GO:0019369; GO:0020037; GO:0031408; GO:0047677; GO:0047987 PATHWAY: Lipid metabolism; arachidonate metabolism. 0 0 PF00305;PF01477; O18883 CHOYP_TXNDC9.1.1 m.22863 sp TXND9_BOVIN 57.82 211 86 3 1 210 9 217 7.93E-87 259 TXND9_BOVIN reviewed Thioredoxin domain-containing protein 9 (Protein 1-4) TXNDC9 APACD Bos taurus (Bovine) 226 cell redox homeostasis [GO:0045454]; queuosine biosynthetic process [GO:0008616] GO:0005634; GO:0005737; GO:0005815; GO:0008616; GO:0030496; GO:0045454 0 0 0 PF00085; O54990 CHOYP_PROM1.2.3 m.31404 sp PROM1_MOUSE 24.538 811 514 23 55 803 54 828 7.93E-60 223 PROM1_MOUSE reviewed Prominin-1 (Antigen AC133 homolog) (Prominin-like protein 1) (CD antigen CD133) Prom1 Prom Proml1 Mus musculus (Mouse) 867 camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; glomerular visceral epithelial cell differentiation [GO:0072112]; photoreceptor cell maintenance [GO:0045494]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042] GO:0001750; GO:0005615; GO:0005783; GO:0005793; GO:0005886; GO:0005887; GO:0005902; GO:0005903; GO:0005929; GO:0009986; GO:0010842; GO:0016324; GO:0031528; GO:0031982; GO:0032420; GO:0042622; GO:0042805; GO:0042995; GO:0043231; GO:0045296; GO:0045494; GO:0060042; GO:0060219; GO:0070062; GO:0071914; GO:0072112; GO:0072139; GO:2000768 0 0 0 PF05478; O70277 CHOYP_LOC100368547.13.40 m.13205 sp TRIM3_RAT 28.333 120 81 3 66 181 625 743 7.93E-09 58.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P19073 CHOYP_CDC42.8.11 m.56725 sp CDC42_YEAST 58.673 196 76 1 38 233 1 191 7.93E-82 245 CDC42_YEAST reviewed Cell division control protein 42 (Suppressor of RHO3 protein 2) CDC42 SRO2 YLR229C L8083.13 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 191 "budding cell apical bud growth [GO:0007118]; budding cell isotropic bud growth [GO:0007119]; cell cycle [GO:0007049]; conjugation with cellular fusion [GO:0000747]; establishment of cell polarity [GO:0030010]; invasive growth in response to glucose limitation [GO:0001403]; pheromone-dependent signal transduction involved in conjugation with cellular fusion [GO:0000750]; positive regulation of exocytosis [GO:0045921]; positive regulation of pseudohyphal growth [GO:2000222]; regulation of cell morphogenesis [GO:0022604]; regulation of exit from mitosis [GO:0007096]; regulation of exocyst localization [GO:0060178]; regulation of initiation of mating projection growth [GO:0031384]; regulation of vacuole fusion, non-autophagic [GO:0032889]; septin ring organization [GO:0031106]; small GTPase mediated signal transduction [GO:0007264]" GO:0000131; GO:0000329; GO:0000747; GO:0000750; GO:0001403; GO:0003924; GO:0005525; GO:0005886; GO:0005934; GO:0005935; GO:0005940; GO:0007049; GO:0007096; GO:0007118; GO:0007119; GO:0007264; GO:0022604; GO:0030010; GO:0031106; GO:0031384; GO:0031965; GO:0032889; GO:0043332; GO:0045921; GO:0060178; GO:2000222 0 0 0 PF00071; P24928 CHOYP_LOC100736022.4.4 m.45944 sp RPB1_HUMAN 53.271 107 46 1 253 355 1855 1961 7.93E-21 103 RPB1_HUMAN reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) POLR2A POLR2 Homo sapiens (Human) 1970 "7-methylguanosine mRNA capping [GO:0006370]; DNA-templated transcription, termination [GO:0006353]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; gene silencing by RNA [GO:0031047]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of RNA splicing [GO:0033120]; positive regulation of viral transcription [GO:0050434]; regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; somatic stem cell population maintenance [GO:0035019]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000398; GO:0003677; GO:0003899; GO:0003968; GO:0005634; GO:0005654; GO:0005665; GO:0006283; GO:0006353; GO:0006355; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0008543; GO:0010467; GO:0031047; GO:0031625; GO:0033120; GO:0035019; GO:0042795; GO:0044822; GO:0046872; GO:0050434 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; Q08D64 CHOYP_LOC583333.1.1 m.44482 sp ABCB6_XENTR 37.255 153 82 3 1 147 151 295 7.93E-24 99.8 ABCB6_XENTR reviewed "ATP-binding cassette sub-family B member 6, mitochondrial" abcb6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 849 cellular iron ion homeostasis [GO:0006879]; transmembrane transport [GO:0055085] GO:0005524; GO:0005741; GO:0005743; GO:0005783; GO:0005794; GO:0005886; GO:0006879; GO:0016021; GO:0042626; GO:0055085 0 0 0 PF00664;PF00005;PF16185; Q4V847 CHOYP_BRAFLDRAFT_117675.1.1 m.33772 sp INT8_XENLA 33.861 1010 604 24 14 993 16 991 7.93E-175 538 INT8_XENLA reviewed Integrator complex subunit 8 (Int8) ints8 Xenopus laevis (African clawed frog) 991 0 GO:0005634 0 0 0 0 Q5ND28 CHOYP_MEGF6.55.59 m.59497 sp SREC_MOUSE 37.778 135 78 5 189 323 213 341 7.93E-17 86.3 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q6P4F7 CHOYP_ARHGAP11A.1.1 m.14045 sp RHGBA_HUMAN 39.044 251 143 6 52 297 44 289 7.93E-42 171 RHGBA_HUMAN reviewed Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A) ARHGAP11A KIAA0013 Homo sapiens (Human) 1023 regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00620; Q7ZY08 CHOYP_LOC586901.1.1 m.18067 sp UBE2T_XENLA 63.158 171 62 1 9 179 1 170 7.93E-80 239 UBE2T_XENLA reviewed Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T) ube2t Xenopus laevis (African clawed frog) 192 cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513] GO:0003682; GO:0004842; GO:0005524; GO:0005634; GO:0006281; GO:0006513; GO:0006974; GO:0051865 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q8R1P4 CHOYP_LOC662190.3.3 m.62555 sp ATG10_MOUSE 54.762 126 53 1 24 145 84 209 7.93E-40 136 ATG10_MOUSE reviewed Ubiquitin-like-conjugating enzyme ATG10 (EC 6.3.2.-) (Autophagy-related protein 10) (APG10-like) (mAPG10) Atg10 Apg10l Mus musculus (Mouse) 215 autophagy [GO:0006914]; autophagy in response to ER overload [GO:0034263]; macroautophagy [GO:0016236]; positive regulation of protein modification process [GO:0031401]; protein lipidation [GO:0006497]; protein modification by small protein conjugation [GO:0032446]; protein transport [GO:0015031] GO:0005622; GO:0005829; GO:0006497; GO:0006914; GO:0015031; GO:0016236; GO:0016874; GO:0019777; GO:0031401; GO:0032446; GO:0034263 0 0 0 PF03987; Q9UQ07 CHOYP_LOC100377851.2.2 m.42811 sp MOK_HUMAN 68.504 127 40 0 5 131 1 127 7.93E-60 192 MOK_HUMAN reviewed MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) MOK RAGE RAGE1 Homo sapiens (Human) 419 protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005929; GO:0006468; GO:0007165; GO:0097546 0 0 0 PF00069; S4R2P9 CHOYP_LOC590169.2.2 m.33233 sp NAC3_MOUSE 31.994 722 375 16 9 636 76 775 7.93E-103 336 NAC3_MOUSE reviewed Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3) (Solute carrier family 8 member 3) Slc8a3 Ncx3 Mus musculus (Mouse) 928 calcium ion export from cell [GO:1990034]; calcium ion import into cell [GO:1990035]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cell communication [GO:0007154]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to hypoxia [GO:0071456]; hematopoietic progenitor cell differentiation [GO:0002244]; learning [GO:0007612]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; metal ion transport [GO:0030001]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; myelination [GO:0042552]; oligodendrocyte differentiation [GO:0048709]; regulation of skeletal muscle contraction [GO:0014819]; sodium ion transmembrane transport [GO:0035725]; telencephalon development [GO:0021537] GO:0002244; GO:0005432; GO:0005741; GO:0005789; GO:0005874; GO:0005887; GO:0006851; GO:0006874; GO:0007154; GO:0007612; GO:0007613; GO:0014819; GO:0015368; GO:0016528; GO:0021537; GO:0030001; GO:0030054; GO:0031226; GO:0031594; GO:0035725; GO:0042383; GO:0042552; GO:0043197; GO:0043204; GO:0046872; GO:0048471; GO:0048709; GO:0051560; GO:0060291; GO:0060402; GO:0070588; GO:0071320; GO:0071456; GO:1990034; GO:1990035 0 0 0 PF03160;PF01699;PF16494; A6H782 CHOYP_TEKT3.1.1 m.37281 sp TEKT3_BOVIN 51.139 395 193 0 60 454 87 481 7.94E-140 413 TEKT3_BOVIN reviewed Tektin-3 TEKT3 Bos taurus (Bovine) 490 cilium morphogenesis [GO:0060271]; regulation of fertilization [GO:0080154]; sperm motility [GO:0030317] GO:0002080; GO:0005874; GO:0030317; GO:0036126; GO:0060271; GO:0080154 0 0 0 0 I3LM39 CHOYP_NEMVEDRAFT_V1G196611.13.13 m.59911 sp CGAS_PIG 26.374 182 97 8 201 354 318 490 7.94E-06 52.8 CGAS_PIG reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) MB21D1 Sus scrofa (Pig) 495 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; P18288 CHOYP_LOC100373045.1.1 m.16825 sp TBAT_ONCMY 93.985 266 13 1 1 266 1 263 7.94E-176 496 TBAT_ONCMY reviewed "Tubulin alpha chain, testis-specific [Cleaved into: Detyrosinated tubulin alpha chain, testis-specific]" 0 Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P21551 CHOYP_LOC100119654.1.1 m.29557 sp WNT1_AMBME 56.857 350 136 3 29 376 32 368 7.94E-144 415 WNT1_AMBME reviewed Protein Wnt-1 WNT-1 Ambystoma mexicanum (Axolotl) 369 multicellular organism development [GO:0007275]; Wnt signaling pathway [GO:0016055] GO:0005578; GO:0007275; GO:0016055 0 0 0 PF00110; P30568 CHOYP_PRP6.2.2 m.34365 sp GSTA_PLEPL 44.495 218 118 3 1 217 1 216 7.94E-61 193 GSTA_PLEPL reviewed Glutathione S-transferase A (GST-A) (EC 2.5.1.18) (GST class-theta) 0 Pleuronectes platessa (European plaice) 225 0 GO:0004364; GO:0005737 0 0 0 PF14497;PF13417; P49263 CHOYP_LOC100375293.1.2 m.45804 sp PXN1_XENLA 27.586 116 77 4 42 153 64 176 7.94E-07 50.8 PXN1_XENLA reviewed Pentraxin fusion protein pxn1 Xenopus laevis (African clawed frog) 416 0 GO:0046872 0 0 0 PF00754;PF00354; Q05B54 CHOYP_DANA_GF24843.1.2 m.17023 sp TM134_BOVIN 39.286 84 51 0 73 156 111 194 7.94E-13 66.2 TM134_BOVIN reviewed Transmembrane protein 134 TMEM134 Bos taurus (Bovine) 195 0 GO:0016021 0 0 0 PF05915; Q05B54 CHOYP_DANA_GF24843.2.2 m.33248 sp TM134_BOVIN 39.286 84 51 0 73 156 111 194 7.94E-13 66.2 TM134_BOVIN reviewed Transmembrane protein 134 TMEM134 Bos taurus (Bovine) 195 0 GO:0016021 0 0 0 PF05915; Q64732 CHOYP_FOXAB-LIKE.1.1 m.7622 sp FOXB1_MOUSE 39.636 275 120 7 91 320 6 279 7.94E-53 179 FOXB1_MOUSE reviewed Forkhead box protein B1 (Transcription factor FKH-5) Foxb1 Fkh5 Foxb1a Foxb1b Mf3 Mus musculus (Mouse) 325 "axon target recognition [GO:0007412]; cell migration in diencephalon [GO:0061381]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; floor plate development [GO:0033504]; hypothalamus cell migration [GO:0021855]; inferior colliculus development [GO:0061379]; lactation [GO:0007595]; mammary gland lobule development [GO:0061377]; mammillary body development [GO:0021767]; mammillothalamic axonal tract development [GO:0061374]; midbrain development [GO:0030901]; negative regulation of neuron apoptotic process [GO:0043524]; somitogenesis [GO:0001756]; spinal cord development [GO:0021510]; telencephalon cell migration [GO:0022029]; thalamus development [GO:0021794]; transcription, DNA-templated [GO:0006351]; urogenital system development [GO:0001655]; visual learning [GO:0008542]" GO:0000981; GO:0001655; GO:0001756; GO:0005634; GO:0006351; GO:0007412; GO:0007595; GO:0008542; GO:0021510; GO:0021767; GO:0021794; GO:0021855; GO:0022029; GO:0030901; GO:0033504; GO:0043524; GO:0043565; GO:0061030; GO:0061374; GO:0061377; GO:0061379; GO:0061381 0 0 0 PF00250; Q80X72 CHOYP_LIGO2.1.2 m.3525 sp LRC15_MOUSE 27.833 406 254 18 1 393 7 386 7.94E-18 89.7 LRC15_MOUSE reviewed Leucine-rich repeat-containing protein 15 Lrrc15 Mus musculus (Mouse) 579 cytokine-mediated signaling pathway [GO:0019221]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813] GO:0001968; GO:0004860; GO:0005518; GO:0005737; GO:0006469; GO:0016021; GO:0019221; GO:0030335; GO:0043236; GO:0046426; GO:0046813; GO:0070062; GO:0090005 0 0 0 PF13855; Q8C9W3 CHOYP_ATS16.3.4 m.21664 sp ATS2_MOUSE 23.983 688 392 27 97 711 123 752 7.94E-41 168 ATS2_MOUSE reviewed A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI) Adamts2 Mus musculus (Mouse) 1213 collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; lung development [GO:0030324]; protein processing [GO:0016485]; skin development [GO:0043588]; spermatogenesis [GO:0007283] GO:0004222; GO:0005578; GO:0007283; GO:0008233; GO:0008270; GO:0016485; GO:0030199; GO:0030324; GO:0030574; GO:0043588 0 0 0 PF05986;PF01562;PF01421;PF00090; O08712 CHOYP_GSPATT00031274001.1.1 m.14697 sp TR11B_MOUSE 30 120 65 2 213 318 41 155 7.95E-07 55.1 TR11B_MOUSE reviewed Tumor necrosis factor receptor superfamily member 11B (Osteoclastogenesis inhibitory factor) (Osteoprotegerin) Tnfrsf11b Ocif Opg Mus musculus (Mouse) 401 apoptotic signaling pathway [GO:0097190]; extracellular matrix organization [GO:0030198]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of bone resorption [GO:0045779]; negative regulation of odontogenesis of dentin-containing tooth [GO:0042489]; positive regulation of MAPK cascade [GO:0043410]; regulation of apoptotic process [GO:0042981]; regulation of cell proliferation [GO:0042127]; response to arsenic-containing substance [GO:0046685]; response to drug [GO:0042493]; response to estrogen [GO:0043627]; response to lipopolysaccharide [GO:0032496]; response to magnesium ion [GO:0032026]; response to nutrient [GO:0007584] GO:0005031; GO:0005578; GO:0005615; GO:0005887; GO:0006954; GO:0006955; GO:0007584; GO:0030198; GO:0032026; GO:0032496; GO:0042127; GO:0042489; GO:0042493; GO:0042981; GO:0043410; GO:0043627; GO:0045779; GO:0046685; GO:0097190 0 0 0 PF00531;PF00020; P18433 CHOYP_CARNS1.2.6 m.3529 sp PTPRA_HUMAN 29.123 673 439 17 395 1046 136 791 7.95E-79 278 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P33005 CHOYP_LOC100535716.3.3 m.65709 sp KALM_CHICK 49.057 53 25 1 1161 1211 115 167 7.95E-09 63.9 KALM_CHICK reviewed Anosmin-1 (Kallmann syndrome protein homolog) ANOS1 KAL KAL1 Gallus gallus (Chicken) 675 cell adhesion [GO:0007155] GO:0004867; GO:0005576; GO:0007155; GO:0009986 0 0 0 PF00041;PF00095; P37801 CHOYP_SMP_078690.2.5 m.1699 sp CLPH_ONCVO 37.302 252 124 11 35 255 84 332 7.95E-33 126 CLPH_ONCVO reviewed Calponin homolog OV9M 0 Onchocerca volvulus 378 0 0 0 0 0 PF00402; P62752 CHOYP_LOC100533345.2.2 m.50611 sp RL23A_RAT 77.876 113 25 0 55 167 31 143 7.95E-55 175 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; Q00719 CHOYP_TRI45.10.23 m.32872 sp MDMC_STRMY 33.01 103 55 4 81 175 125 221 7.95E-12 64.7 MDMC_STRMY reviewed O-methyltransferase MdmC (EC 2.1.1.-) mdmC Streptomyces mycarofaciens 221 antibiotic biosynthetic process [GO:0017000] GO:0008171; GO:0017000; GO:0046872 0 0 0 PF01596; Q10126 CHOYP_MYO3AL.1.1 m.8124 sp YSM6_CAEEL 27.811 169 108 5 26 187 7 168 7.95E-07 53.9 YSM6_CAEEL reviewed Putative uncharacterized transposon-derived protein F52C9.6 F52C9.6 Caenorhabditis elegans 279 0 0 0 0 0 PF00078; Q12955 CHOYP_LOC578974.11.11 m.64612 sp ANK3_HUMAN 40.777 103 61 0 4 106 90 192 7.95E-20 86.3 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q3U1T9 CHOYP_LOC100167728.2.2 m.42340 sp DEN1B_MOUSE 46.667 420 210 4 1 416 1 410 7.95E-130 411 DEN1B_MOUSE reviewed DENN domain-containing protein 1B (Connecdenn 2) Dennd1b Mus musculus (Mouse) 766 endocytic recycling [GO:0032456]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell cytokine production [GO:0035745] GO:0005829; GO:0015031; GO:0017112; GO:0017137; GO:0030136; GO:0032456; GO:0035745; GO:0043547; GO:0050776; GO:0050852 0 0 0 PF03455;PF02141;PF03456; Q54YK1 CHOYP_NEMVEDRAFT_V1G236707.1.1 m.11050 sp Y8631_DICDI 37.751 249 140 7 1 242 114 354 7.95E-33 128 Y8631_DICDI reviewed Putative UDP-sugar transporter DDB_G0278631 DDB_G0278631 Dictyostelium discoideum (Slime mold) 382 carbohydrate transport [GO:0008643] GO:0008643; GO:0015165; GO:0016021 0 0 0 PF03151; Q5R5L7 CHOYP_LOC100176335.6.7 m.51599 sp ARRD3_PONAB 32.768 354 218 8 1 337 3 353 7.95E-53 183 ARRD3_PONAB reviewed Arrestin domain-containing protein 3 ARRDC3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 414 0 GO:0005764; GO:0005769; GO:0005886 0 0 0 PF02752;PF00339; Q5T8D3 CHOYP_ACBD5.1.2 m.16744 sp ACBD5_HUMAN 27.487 593 291 18 20 577 44 532 7.95E-49 181 ACBD5_HUMAN reviewed Acyl-CoA-binding domain-containing protein 5 ACBD5 KIAA1996 Homo sapiens (Human) 534 pexophagy [GO:0030242]; transport [GO:0006810] GO:0000062; GO:0005634; GO:0005654; GO:0005777; GO:0005778; GO:0006810; GO:0008289; GO:0016020; GO:0016021; GO:0030242; GO:0043231 0 0 0 PF00887; Q8CAL5 CHOYP_LOC100558465.1.1 m.51592 sp GPC5_MOUSE 27.972 572 358 19 34 587 30 565 7.95E-53 192 GPC5_MOUSE reviewed Glypican-5 [Cleaved into: Secreted glypican-5] Gpc5 Mus musculus (Mouse) 572 glycosaminoglycan biosynthetic process [GO:0006024] GO:0005578; GO:0005615; GO:0005796; GO:0005887; GO:0006024; GO:0031225; GO:0043395 0 0 0 PF01153; Q8R4G6 CHOYP_LOC101168186.1.1 m.38051 sp MGT5A_MOUSE 38.017 121 71 1 1 121 3 119 7.95E-21 92.4 MGT5A_MOUSE reviewed "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.155) (Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase) (GlcNAc-T V) (GNT-V) (Mannoside acetylglucosaminyltransferase 5) (N-acetylglucosaminyl-transferase V)" Mgat5 Mus musculus (Mouse) 740 protein N-linked glycosylation [GO:0006487] GO:0000139; GO:0005794; GO:0006487; GO:0008375; GO:0016021; GO:0016757; GO:0030144; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF15027; Q8VEK6 CHOYP_ING3.1.1 m.2976 sp ING3_MOUSE 47.439 449 175 12 39 455 1 420 7.95E-126 374 ING3_MOUSE reviewed Inhibitor of growth protein 3 (p47ING3) Ing3 Mus musculus (Mouse) 421 "chromatin modification [GO:0016568]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; positive regulation of apoptotic process [GO:0043065]; regulation of growth [GO:0040008]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000812; GO:0004402; GO:0005634; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0016568; GO:0032777; GO:0035064; GO:0035267; GO:0040008; GO:0043065; GO:0043967; GO:0043968 0 0 0 PF12998; Q91YD4 CHOYP_TRPM2.2.12 m.31870 sp TRPM2_MOUSE 25.908 633 363 21 119 688 486 1075 7.95E-40 164 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; P0DKR2 CHOYP_TCAIM.1.1 m.2404 sp TCAIM_RAT 33.056 481 285 12 24 479 31 499 7.96E-70 234 TCAIM_RAT reviewed "T-cell activation inhibitor, mitochondrial (Tolerance-associated gene-1) (TOAG-1)" Tcaim Toag1 Rattus norvegicus (Rat) 505 0 GO:0005739 0 0 0 PF14687;PF14688; P16157 CHOYP_LOC583072.17.25 m.54393 sp ANK1_HUMAN 24.66 515 309 14 2 474 281 758 7.96E-21 101 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P46531 CHOYP_NOTC1.4.4 m.48476 sp NOTC1_HUMAN 40.698 86 35 4 366 450 801 871 7.96E-06 53.5 NOTC1_HUMAN reviewed Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 TAN1 Homo sapiens (Human) 2555 "aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axonogenesis [GO:0007409]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium morphogenesis [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-4 secretion [GO:0072602]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of auditory receptor cell differentiation [GO:0045608]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; organ regeneration [GO:0031100]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral transcription [GO:0050434]; prostate gland epithelium morphogenesis [GO:0060740]; pulmonary valve morphogenesis [GO:0003184]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; tissue regeneration [GO:0042246]; transcription initiation from RNA polymerase II promoter [GO:0006367]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222]" GO:0000122; GO:0000139; GO:0001047; GO:0001190; GO:0001669; GO:0001701; GO:0001708; GO:0001837; GO:0001889; GO:0001947; GO:0002040; GO:0002052; GO:0002193; GO:0002437; GO:0003157; GO:0003160; GO:0003162; GO:0003169; GO:0003180; GO:0003181; GO:0003184; GO:0003192; GO:0003198; GO:0003203; GO:0003207; GO:0003208; GO:0003209; GO:0003213; GO:0003214; GO:0003219; GO:0003222; GO:0003241; GO:0003256; GO:0003270; GO:0003273; GO:0003344; GO:0003700; GO:0004857; GO:0004872; GO:0005509; GO:0005576; GO:0005634; GO:0005654; GO:0005789; GO:0005829; GO:0005886; GO:0005912; GO:0006355; GO:0006367; GO:0006955; GO:0006959; GO:0007219; GO:0007221; GO:0007283; GO:0007368; GO:0007386; GO:0007409; GO:0007440; GO:0007492; GO:0007507; GO:0008284; GO:0008285; GO:0009912; GO:0009986; GO:0010718; GO:0010812; GO:0010832; GO:0014031; GO:0014807; GO:0016021; GO:0016324; GO:0019899; GO:0021515; GO:0021915; GO:0030216; GO:0030279; GO:0030324; GO:0030335; GO:0030513; GO:0030514; GO:0030900; GO:0031069; GO:0031100; GO:0031490; GO:0031960; GO:0032495; GO:0032496; GO:0035116; GO:0035148; GO:0035914; GO:0035924; GO:0042246; GO:0043065; GO:0043086; GO:0043235; GO:0043565; GO:0045070; GO:0045603; GO:0045608; GO:0045618; GO:0045662; GO:0045668; GO:0045747; GO:0045892; GO:0045893; GO:0045944; GO:0045955; GO:0046427; GO:0046533; GO:0048103; GO:0048708; GO:0048709; GO:0048711; GO:0048715; GO:0048754; GO:0050434; GO:0050679; GO:0050768; GO:0055008; GO:0060038; GO:0060045; GO:0060253; GO:0060271; GO:0060317; GO:0060411; GO:0060412; GO:0060528; GO:0060740; GO:0060768; GO:0060842; GO:0060843; GO:0060948; GO:0060956; GO:0060979; GO:0060982; GO:0061314; GO:0061384; GO:0061419; GO:0070986; GO:0071372; GO:0072017; GO:0072044; GO:0072144; GO:0072602; GO:0090051; GO:0090090; GO:0097150; GO:1901201; GO:1902263; GO:2000737; GO:2000811; GO:2000974; GO:2001027 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P63018 CHOYP_BRAFLDRAFT_114843.1.2 m.14727 sp HSP7C_RAT 83.966 237 34 1 1 237 87 319 7.96E-141 411 HSP7C_RAT reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) Hspa8 Hsc70 Hsc73 Rattus norvegicus (Rat) 646 "aging [GO:0007568]; axo-dendritic transport [GO:0008088]; cellular protein complex disassembly [GO:0043624]; cellular response to cadmium ion [GO:0071276]; cellular response to heat [GO:0034605]; cerebellum development [GO:0021549]; chaperone-mediated autophagy [GO:0061684]; chaperone-mediated autophagy translocation complex disassembly [GO:1904764]; chaperone-mediated protein folding [GO:0061077]; chaperone mediated protein folding requiring cofactor [GO:0051085]; chaperone-mediated protein transport involved in chaperone-mediated autophagy [GO:0061741]; clathrin coat disassembly [GO:0072318]; estrous cycle [GO:0044849]; forebrain development [GO:0030900]; G1/S transition of mitotic cell cycle [GO:0000082]; intracellular protein transmembrane import [GO:0044743]; kidney development [GO:0001822]; mRNA processing [GO:0006397]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of catalytic activity [GO:0043085]; positive regulation of gene expression [GO:0010628]; positive regulation of lysosomal membrane permeability [GO:0097214]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein refolding [GO:1904592]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein autophosphorylation [GO:0046777]; protein import into nucleus [GO:0006606]; protein refolding [GO:0042026]; regulation of protein complex stability [GO:0061635]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to nickel cation [GO:0010045]; response to odorant [GO:1990834]; response to progesterone [GO:0032570]; response to starvation [GO:0042594]; RNA splicing [GO:0008380]; sensory perception of smell [GO:0007608]; skeletal muscle tissue development [GO:0007519]; slow axonal transport [GO:1990832]; transcription, DNA-templated [GO:0006351]" GO:0000082; GO:0000974; GO:0001822; GO:0001916; GO:0001917; GO:0003723; GO:0005102; GO:0005524; GO:0005634; GO:0005681; GO:0005730; GO:0005737; GO:0005764; GO:0005765; GO:0005776; GO:0005829; GO:0005874; GO:0005882; GO:0005886; GO:0006351; GO:0006397; GO:0006606; GO:0007519; GO:0007568; GO:0007608; GO:0008021; GO:0008088; GO:0008134; GO:0008380; GO:0009408; GO:0009986; GO:0010045; GO:0010628; GO:0010667; GO:0014069; GO:0014823; GO:0016887; GO:0019899; GO:0021549; GO:0030424; GO:0030425; GO:0030529; GO:0030900; GO:0031686; GO:0032279; GO:0032355; GO:0032570; GO:0034605; GO:0042026; GO:0042277; GO:0042470; GO:0042493; GO:0042594; GO:0042623; GO:0043005; GO:0043025; GO:0043085; GO:0043195; GO:0043197; GO:0043198; GO:0043204; GO:0043234; GO:0043531; GO:0043624; GO:0044743; GO:0044849; GO:0045121; GO:0045471; GO:0045862; GO:0045892; GO:0046777; GO:0048471; GO:0050766; GO:0051082; GO:0051085; GO:0061077; GO:0061635; GO:0061684; GO:0061741; GO:0070062; GO:0071276; GO:0072318; GO:0097214; GO:1903206; GO:1904592; GO:1904593; GO:1904764; GO:1990124; GO:1990832; GO:1990833; GO:1990834; GO:1990836 0 0 0 PF00012; Q0D289 CHOYP_LOC100879797.1.1 m.44238 sp CP052_DANRE 49.708 171 78 4 19 186 1 166 7.96E-54 171 CP052_DANRE reviewed Uncharacterized protein C16orf52 homolog zgc:153595 Danio rerio (Zebrafish) (Brachydanio rerio) 167 0 0 0 0 0 0 Q2TBN3 CHOYP_CETN1.2.3 m.50071 sp CETN2_BOVIN 62.963 162 58 1 1 162 10 169 7.96E-66 201 CETN2_BOVIN reviewed Centrin-2 CETN2 Bos taurus (Bovine) 172 cell division [GO:0051301]; centriole replication [GO:0007099]; mitotic nuclear division [GO:0007067]; nucleotide-excision repair [GO:0006289]; regulation of cytokinesis [GO:0032465]; spermatogenesis [GO:0007283] GO:0005509; GO:0005814; GO:0006289; GO:0007067; GO:0007099; GO:0007283; GO:0032391; GO:0032465; GO:0036064; GO:0051301; GO:0071942 0 0 0 PF13499;PF13833; Q2TBN3 CHOYP_PHUM_PHUM454190.1.1 m.65767 sp CETN2_BOVIN 62.963 162 58 1 1 162 10 169 7.96E-66 201 CETN2_BOVIN reviewed Centrin-2 CETN2 Bos taurus (Bovine) 172 cell division [GO:0051301]; centriole replication [GO:0007099]; mitotic nuclear division [GO:0007067]; nucleotide-excision repair [GO:0006289]; regulation of cytokinesis [GO:0032465]; spermatogenesis [GO:0007283] GO:0005509; GO:0005814; GO:0006289; GO:0007067; GO:0007099; GO:0007283; GO:0032391; GO:0032465; GO:0036064; GO:0051301; GO:0071942 0 0 0 PF13499;PF13833; Q4N4N8 CHOYP_ISCW_ISCW016183.1.1 m.13874 sp TXND_THEPA 32.584 178 110 3 139 313 24 194 7.96E-21 92.4 TXND_THEPA reviewed Thioredoxin domain-containing protein (Membrane protein 23) (mp23) TP02_0602 Theileria parva (East coast fever infection agent) 220 cell redox homeostasis [GO:0045454] GO:0005789; GO:0016021; GO:0045454 0 0 0 PF00085; Q5I2E5 CHOYP_MFAP4.2.3 m.55130 sp FCN2_BOVIN 50.35 143 64 3 14 156 160 295 7.96E-38 136 FCN2_BOVIN reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) FCN2 Bos taurus (Bovine) 329 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0046872 0 0 0 PF01391;PF00147; Q5XIA2 CHOYP_BRAFLDRAFT_242615.1.1 m.54577 sp SZRD1_RAT 43.226 155 72 6 8 154 5 151 7.96E-30 108 SZRD1_RAT reviewed SUZ domain-containing protein 1 Szrd1 Rattus norvegicus (Rat) 152 0 0 0 0 0 PF12752;PF12901; Q5ZT34 CHOYP_LOC586122.3.4 m.63155 sp BIOC_LEGPH 25.926 135 97 1 141 275 8 139 7.96E-08 56.6 BIOC_LEGPH reviewed Malonyl-[acyl-carrier protein] O-methyltransferase (Malonyl-ACP O-methyltransferase) (EC 2.1.1.197) (Biotin synthesis protein BioC) bioC lpg2331 Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) 284 biotin biosynthetic process [GO:0009102] GO:0009102; GO:0010340 PATHWAY: Cofactor biosynthesis; biotin biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00835}. 0 0 PF08241; Q8BT14 CHOYP_LOC100367166.1.1 m.1262 sp CNOT4_MOUSE 55.484 465 156 9 2 460 7 426 7.96E-159 472 CNOT4_MOUSE reviewed CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) Cnot4 Not4 Mus musculus (Mouse) 575 "protein autoubiquitination [GO:0051865]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0004842; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0016874; GO:0030014; GO:0044822; GO:0051865 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00076; Q8C0J6 CHOYP_SOWAHC.1.1 m.2288 sp SWAHC_MOUSE 43.796 137 72 1 157 288 246 382 7.96E-35 135 SWAHC_MOUSE reviewed Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) Sowahc Ankrd57 Mus musculus (Mouse) 512 0 0 0 0 0 PF12796; Q99020 CHOYP_TPM.7.19 m.15554 sp ROAA_MOUSE 56.098 164 67 2 41 200 54 216 7.96E-54 177 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q9GLP1 CHOYP_DWIL_GK22241.1.1 m.42280 sp FA5_PIG 36.207 116 74 0 1 116 1200 1315 7.96E-11 60.8 FA5_PIG reviewed Coagulation factor V (Activated protein C cofactor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain] F5 Sus scrofa (Pig) 2258 blood coagulation [GO:0007596] GO:0005507; GO:0005576; GO:0007596 0 0 0 PF07732;PF00754;PF06049; Q9Y6N5 CHOYP_BRAFLDRAFT_81609.1.1 m.94 sp SQRD_HUMAN 52.899 414 192 3 31 443 39 450 7.96E-165 474 SQRD_HUMAN reviewed "Sulfide:quinone oxidoreductase, mitochondrial (SQOR) (EC 1.8.5.-)" SQRDL CGI-44 Homo sapiens (Human) 450 "hydrogen sulfide metabolic process [GO:0070813]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]" GO:0005743; GO:0048038; GO:0070221; GO:0070224; GO:0070813 0 0 0 PF07992; O95671 CHOYP_ASMTL.1.1 m.20115 sp ASML_HUMAN 39.894 188 112 1 212 398 423 610 7.97E-39 150 ASML_HUMAN reviewed N-acetylserotonin O-methyltransferase-like protein (ASMTL) (EC 2.1.1.-) ASMTL Homo sapiens (Human) 621 0 GO:0005737; GO:0008171 0 0 cd00555; PF16864;PF02545;PF00891; Q08CG8 CHOYP_AGAP_AGAP001358.1.1 m.48754 sp RNF44_DANRE 47 100 45 2 278 375 346 439 7.97E-21 97.1 RNF44_DANRE reviewed RING finger protein 44 rnf44 zgc:153103 Danio rerio (Zebrafish) (Brachydanio rerio) 448 "proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005654; GO:0005737; GO:0006355; GO:0008270; GO:0043161; GO:0061630 0 0 0 PF13639; Q3SZH7 CHOYP_LKHA4.1.2 m.27773 sp LKHA4_BOVIN 47.345 226 119 0 1 226 385 610 7.97E-74 238 LKHA4_BOVIN reviewed Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) LTA4H Bos taurus (Bovine) 611 leukotriene biosynthetic process [GO:0019370]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508] GO:0004177; GO:0004301; GO:0004463; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0006508; GO:0008270; GO:0019370; GO:0042277; GO:0043171; GO:0044822; GO:0070006; GO:0070062 PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. 0 0 PF09127;PF01433; Q3SZQ6 CHOYP_BRAFLDRAFT_114866.1.5 m.6859 sp RL32_BOVIN 77.444 133 30 0 25 157 3 135 7.97E-74 220 RL32_BOVIN reviewed 60S ribosomal protein L32 RPL32 Bos taurus (Bovine) 135 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 cd00513; PF01655; Q3UPY5 CHOYP_GLB1L2.1.1 m.5029 sp GLBL2_MOUSE 43.947 603 301 11 44 643 54 622 7.97E-159 474 GLBL2_MOUSE reviewed Beta-galactosidase-1-like protein 2 (EC 3.2.1.-) Glb1l2 Mus musculus (Mouse) 636 carbohydrate metabolic process [GO:0005975] GO:0004565; GO:0005576; GO:0005773; GO:0005975 0 0 0 PF01301; Q54F46 CHOYP_BC1G_06991.2.4 m.32951 sp WARA_DICDI 37.327 217 135 1 3 218 379 595 7.97E-38 142 WARA_DICDI reviewed Homeobox protein Wariai (Homeobox protein 1) (DdHbx-1) warA hbx1 wri DDB_G0291075 Dictyostelium discoideum (Slime mold) 803 "anatomical structure morphogenesis [GO:0009653]; multicellular organism development [GO:0007275]; protein targeting to plasma membrane [GO:0072661]; regulation of cell differentiation [GO:0045595]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0007275; GO:0008093; GO:0009653; GO:0030507; GO:0043565; GO:0045595; GO:0072661 0 0 0 PF00023;PF12796;PF00046; Q5NVM9 CHOYP_BRAFLDRAFT_114843.1.2 m.14729 sp HSP7C_PONAB 93.197 147 6 1 1 147 156 298 7.97E-91 279 HSP7C_PONAB reviewed Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) HSPA8 HSC70 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 646 "mRNA processing [GO:0006397]; negative regulation of transcription, DNA-templated [GO:0045892]; RNA splicing [GO:0008380]" GO:0000974; GO:0005524; GO:0005634; GO:0005681; GO:0005730; GO:0005886; GO:0006397; GO:0008380; GO:0030529; GO:0042470; GO:0045892 0 0 0 PF00012; Q8JI28 CHOYP_LOC591417.1.2 m.15695 sp TLL1_XENLA 23.496 532 304 23 42 493 358 866 7.97E-11 68.9 TLL1_XENLA reviewed Tolloid-like protein 1 (EC 3.4.24.-) (Metalloprotease xolloid-like) (Xenopus tolloid-like protein 1) (Xlr) tll1 xlr Xenopus laevis (African clawed frog) 1007 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0004222; GO:0005509; GO:0005576; GO:0007275; GO:0008270; GO:0030154 0 0 0 PF01400;PF00431; Q8QZX0 CHOYP_LOC100369427.1.1 m.1868 sp SBK1_MOUSE 50.538 279 138 0 26 304 40 318 7.97E-103 311 SBK1_MOUSE reviewed Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1) Sbk1 Sbk Mus musculus (Mouse) 417 0 GO:0004674; GO:0005524; GO:0005737 0 0 0 PF00069; Q923P0 CHOYP_VWA2.1.3 m.3526 sp COKA1_MOUSE 32.857 140 89 3 26 165 177 311 7.97E-12 71.2 COKA1_MOUSE reviewed Collagen alpha-1(XX) chain Col20a1 Mus musculus (Mouse) 1320 0 GO:0005581; GO:0005615 0 0 0 PF01391;PF00041;PF00092; Q9R1R2 CHOYP_BRAFLDRAFT_57028.1.1 m.55583 sp TRIM3_MOUSE 27.011 174 118 4 161 332 578 744 7.97E-12 69.7 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P32031 CHOYP_FOXG1.1.1 m.36055 sp SLP2_DROME 72.549 153 34 3 192 340 159 307 7.98E-69 230 SLP2_DROME reviewed Fork head domain transcription factor slp2 (Sloppy paired locus protein 2) slp2 CG2939 Drosophila melanogaster (Fruit fly) 445 "segment polarity determination [GO:0007367]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0005634; GO:0006351; GO:0007367; GO:0043565 0 0 0 PF00250; P91778 CHOYP_AMY.2.3 m.15473 sp AMY_PECMA 67.742 279 82 2 1 279 138 408 7.98E-135 393 AMY_PECMA reviewed "Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)" 0 Pecten maximus (King scallop) (Pilgrim's clam) 508 carbohydrate metabolic process [GO:0005975] GO:0004556; GO:0005975; GO:0046872 0 0 0 PF00128;PF02806; Q24306 CHOYP_AAEL_AAEL009074.3.3 m.56196 sp DIAP1_DROME 44 100 56 0 59 158 218 317 7.98E-24 107 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q4V8R6 CHOYP_LOC100487020.1.1 m.10084 sp E4F1_DANRE 27.381 420 266 10 322 721 138 538 7.98E-26 117 E4F1_DANRE reviewed Transcription factor E4F1 (EC 6.3.2.-) (Putative E3 ubiquitin-protein ligase E4F1) (Transcription factor E4F) e4f1 zgc:114190 Danio rerio (Zebrafish) (Brachydanio rerio) 719 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of cell cycle process [GO:0010564]; regulation of growth [GO:0040008]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0003700; GO:0005654; GO:0005737; GO:0006351; GO:0007067; GO:0010564; GO:0016567; GO:0016874; GO:0040008; GO:0046872; GO:0051301 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13912; Q5RAS5 CHOYP_TSPAN18A.2.2 m.50689 sp TSN6_PONAB 24.138 261 154 6 11 270 18 235 7.98E-10 61.2 TSN6_PONAB reviewed Tetraspanin-6 (Tspan-6) TSPAN6 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 245 negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway [GO:0039532]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123] GO:0004871; GO:0016021; GO:0039532; GO:0043123; GO:0070062; GO:1901223 0 0 0 PF00335; Q86UY6 CHOYP_LOC100366932.1.1 m.36598 sp NAA40_HUMAN 56.364 220 94 2 45 263 1 219 7.98E-88 264 NAA40_HUMAN reviewed N-alpha-acetyltransferase 40 (EC 2.3.1.-) (N-acetyltransferase 11) (NatD catalytic subunit) NAA40 NAT11 Homo sapiens (Human) 237 lipid metabolic process [GO:0006629] GO:0006629; GO:0008080 0 0 0 PF00583; Q96DM1 CHOYP_LOC101358792.1.2 m.21639 sp PGBD4_HUMAN 34.568 81 48 2 86 161 103 183 7.98E-06 48.1 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9X6U2 CHOYP_TMO_0856.1.3 m.5045 sp BDHA_CUPNH 40.927 259 148 3 12 269 4 258 7.98E-66 208 BDHA_CUPNH reviewed D-beta-hydroxybutyrate dehydrogenase (BDH) (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (3-HBDH) hbdH1 H16_A1334 Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 258 0 GO:0003858 0 0 0 PF00106; A4IGF3 CHOYP_FCGBP.1.4 m.29067 sp ATP23_DANRE 40.094 212 99 6 20 216 29 227 7.99E-41 143 ATP23_DANRE reviewed Mitochondrial inner membrane protease ATP23 homolog (EC 3.4.24.-) atp23 xrcc6bp1 zgc:162885 Danio rerio (Zebrafish) (Brachydanio rerio) 254 0 GO:0004222; GO:0046872 0 0 0 PF09768; P24014 CHOYP_BRAFLDRAFT_69264.1.6 m.3599 sp SLIT_DROME 31.472 197 98 3 34 205 543 727 7.99E-23 102 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P35282 CHOYP_RAB21.1.1 m.56542 sp RAB21_MOUSE 78.922 204 39 1 9 208 16 219 7.99E-118 337 RAB21_MOUSE reviewed Ras-related protein Rab-21 (Rab-12) Rab21 Mus musculus (Mouse) 222 anterograde axonal transport [GO:0008089]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; protein transport [GO:0015031]; regulation of axon extension [GO:0030516]; regulation of endocytosis [GO:0030100]; regulation of exocytosis [GO:0017157]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005768; GO:0005769; GO:0005789; GO:0005802; GO:0005925; GO:0007264; GO:0008089; GO:0009898; GO:0012506; GO:0015031; GO:0017157; GO:0019003; GO:0030100; GO:0030516; GO:0030659; GO:0032154; GO:0032580; GO:0043005; GO:0048260; GO:0050775; GO:0070062; GO:0098559; GO:1904115; GO:2000643 0 0 0 PF00071; P53817 CHOYP_BRAFLDRAFT_119296.6.16 m.23185 sp HRSL3_RAT 37.179 156 80 3 18 161 3 152 7.99E-26 100 HRSL3_RAT reviewed HRAS-like suppressor 3 (HRSL3) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A1/A2) (H-rev 107 protein) Pla2g16 H-rev107 Hrasls3 Hrev107 Rattus norvegicus (Rat) 160 lipid catabolic process [GO:0016042]; negative regulation of cell cycle [GO:0045786]; phospholipid biosynthetic process [GO:0008654] GO:0004623; GO:0005737; GO:0005783; GO:0008654; GO:0008970; GO:0016020; GO:0016021; GO:0016042; GO:0045786; GO:0048471; GO:0052739; GO:0052740 0 0 0 PF04970; Q5R7D0 CHOYP_COX18.1.1 m.18091 sp COX18_PONAB 33.333 279 161 7 83 358 64 320 7.99E-37 138 COX18_PONAB reviewed Mitochondrial inner membrane protein COX18 COX18 OXA1L2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 334 protein insertion into mitochondrial membrane [GO:0051204]; respiratory chain complex IV assembly [GO:0008535] GO:0008535; GO:0008565; GO:0031305; GO:0051204 0 0 0 PF02096; Q6GNM0 CHOYP_ZADH2.1.3 m.13138 sp NRM_XENLA 27.374 179 111 6 51 215 78 251 7.99E-08 54.7 NRM_XENLA reviewed Nurim (Nuclear envelope membrane protein) (Nuclear rim protein) nrm Xenopus laevis (African clawed frog) 285 0 GO:0005635; GO:0005637; GO:0016021 0 0 0 0 Q6PBF0 CHOYP_RL8.10.10 m.65636 sp RL8_XENTR 82.031 256 46 0 1 256 1 256 7.99E-156 436 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q6PBF0 CHOYP_RL8.3.10 m.22754 sp RL8_XENTR 82.031 256 46 0 1 256 1 256 7.99E-156 436 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q86Z23 CHOYP_BRAFLDRAFT_69134.2.13 m.10914 sp C1QL4_HUMAN 36.429 140 70 7 24 156 110 237 7.99E-18 80.5 C1QL4_HUMAN reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) C1QL4 CTRP11 Homo sapiens (Human) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8R0M8 CHOYP_LOC100368578.1.1 m.44007 sp MOT5_MOUSE 23.256 344 216 7 1 328 103 414 7.99E-20 93.2 MOT5_MOUSE reviewed Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) 500 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; Q9BRZ2 CHOYP_TRI18.5.6 m.56595 sp TRI56_HUMAN 36.916 214 121 6 22 226 9 217 7.99E-33 138 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; A0JPI9 CHOYP_BRAFLDRAFT_66304.1.3 m.7277 sp LR74A_RAT 27.542 472 311 10 5 462 12 466 8.00E-50 182 LR74A_RAT reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) Lrrc74a Lrrc74 Rattus norvegicus (Rat) 479 0 0 0 0 0 PF13516; D5FKJ3 CHOYP_LOC574855.5.9 m.45621 sp MRSA_PSESY 39.535 86 50 1 147 230 160 245 8.00E-09 58.5 MRSA_PSESY reviewed 2-ketoarginine methyltransferase (EC 2.1.1.243) mrsA Pseudomonas syringae pv. syringae 350 antibiotic biosynthetic process [GO:0017000]; methylation [GO:0032259] GO:0008757; GO:0017000; GO:0032259 PATHWAY: Antibiotic biosynthesis. {ECO:0000269|PubMed:20190091}. 0 0 0 P13590 CHOYP_PHUM_PHUM080420.2.2 m.46925 sp NCAM1_CHICK 25.408 429 263 23 190 596 9 402 8.00E-06 54.3 NCAM1_CHICK reviewed Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) NCAM1 Gallus gallus (Chicken) 1091 cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; neuron projection development [GO:0031175]; regulation of synaptic plasticity [GO:0048167] GO:0005886; GO:0007155; GO:0016021; GO:0030198; GO:0031175; GO:0048167 0 0 0 PF00041;PF07679; P35556 CHOYP_LOC100374579.2.3 m.8775 sp FBN2_HUMAN 35.15 532 304 21 12 534 1073 1572 8.00E-61 227 FBN2_HUMAN reviewed Fibrillin-2 [Cleaved into: Fibrillin-2 C-terminal peptide] FBN2 Homo sapiens (Human) 2912 bone trabecula formation [GO:0060346]; camera-type eye development [GO:0043010]; embryonic eye morphogenesis [GO:0048048]; embryonic limb morphogenesis [GO:0030326]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of bone mineralization [GO:0030501]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cellular response to growth factor stimulus [GO:0090287]; sequestering of TGFbeta in extracellular matrix [GO:0035583] GO:0001527; GO:0005201; GO:0005509; GO:0005576; GO:0022617; GO:0030023; GO:0030198; GO:0030326; GO:0030501; GO:0031012; GO:0035583; GO:0043010; GO:0045669; GO:0048048; GO:0060346; GO:0090287 0 0 0 PF12662;PF07645;PF12661;PF00683; P36633 CHOYP_BRAFLDRAFT_217424.1.2 m.906 sp AOC1_RAT 38.115 732 430 10 80 803 1 717 8.00E-178 533 AOC1_RAT reviewed Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) Aoc1 Abp1 Rattus norvegicus (Rat) 746 amine metabolic process [GO:0009308]; cellular response to azide [GO:0097185]; cellular response to copper ion [GO:0071280]; cellular response to copper ion starvation [GO:0035874]; cellular response to histamine [GO:0071420]; oxidation-reduction process [GO:0055114]; response to antibiotic [GO:0046677]; response to drug [GO:0042493] GO:0004872; GO:0005507; GO:0005615; GO:0005886; GO:0005923; GO:0008131; GO:0008144; GO:0008201; GO:0008270; GO:0009308; GO:0032403; GO:0035874; GO:0042493; GO:0046677; GO:0048038; GO:0052597; GO:0052598; GO:0052599; GO:0052600; GO:0055114; GO:0071280; GO:0071420; GO:0097185 0 0 0 PF01179;PF02727;PF02728; P49797 CHOYP_LOC588980.1.1 m.65760 sp RGS3_RAT 48.837 172 86 1 252 421 788 959 8.00E-45 170 RGS3_RAT reviewed Regulator of G-protein signaling 3 (RGS3) (SRB-RGS) Rgs3 Rattus norvegicus (Rat) 967 negative regulation of signal transduction [GO:0009968]; signal transduction [GO:0007165] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0007165; GO:0009968 0 0 0 PF00595;PF00615; P79110 CHOYP_LOC660776.1.1 m.53402 sp TXTP_BOVIN 65.563 302 102 2 17 317 9 309 8.00E-144 410 TXTP_BOVIN reviewed "Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)" SLC25A1 SLC20A3 Bos taurus (Bovine) 311 translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005743; GO:0006412; GO:0016021; GO:0055085 0 0 0 PF00153; Q11212 CHOYP_CRE_00778.1.1 m.49408 sp ACT_SPOLI 94.845 97 5 0 42 138 25 121 8.00E-66 202 ACT_SPOLI reviewed Actin (Fragment) 0 Spodoptera littoralis (Egyptian cotton leafworm) 164 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q16762 CHOYP_THTM.1.1 m.47263 sp THTR_HUMAN 32.364 275 170 8 10 270 10 282 8.00E-42 148 THTR_HUMAN reviewed Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) TST Homo sapiens (Human) 297 cyanate catabolic process [GO:0009440]; epithelial cell differentiation [GO:0030855]; rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029] GO:0004792; GO:0005615; GO:0005739; GO:0005743; GO:0005759; GO:0008097; GO:0009440; GO:0030855; GO:0035928; GO:0051029; GO:0070062 0 0 0 PF00581; Q6R1L1 CHOYP_TAF7.1.1 m.12714 sp TAF7_CRIGR 42.643 333 166 7 15 334 11 331 8.00E-69 221 TAF7_CRIGR reviewed Transcription initiation factor TFIID subunit 7 TAF7 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 341 "regulation of transcription, DNA-templated [GO:0006355]; spermine transport [GO:0000296]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000296; GO:0005669; GO:0006355; GO:0006367; GO:0071339 0 0 cd08047; PF04658; Q8IZE3 CHOYP_LOC752280.1.1 m.14646 sp PACE1_HUMAN 37.385 436 259 5 1 432 1 426 8.00E-90 301 PACE1_HUMAN reviewed Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3) SCYL3 PACE1 Homo sapiens (Human) 742 cell migration [GO:0016477]; protein phosphorylation [GO:0006468] GO:0005524; GO:0005737; GO:0005794; GO:0006468; GO:0016477; GO:0030027 0 0 0 PF00069; Q924N4 CHOYP_DPER_GL11178.1.1 m.32121 sp S12A6_MOUSE 51.73 549 229 10 87 605 106 648 8.00E-178 537 S12A6_MOUSE reviewed Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3) Slc12a6 Kcc3 Mus musculus (Mouse) 1150 cellular hypotonic salinity response [GO:0071477]; chemical synaptic transmission [GO:0007268]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0007268; GO:0015379; GO:0016323; GO:0022820; GO:0030424; GO:0071477 0 0 0 PF00324;PF03522; O45782 CHOYP_LOC100178217.1.2 m.26570 sp ARD17_CAEEL 29.348 368 215 13 24 360 1 354 8.01E-34 133 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; O73787 CHOYP_EF-1A.9.9 m.63038 sp GCP3_XENLA 66.084 286 96 1 1 285 469 754 8.01E-134 403 GCP3_XENLA reviewed Gamma-tubulin complex component 3 homolog (Gamma-ring complex protein 109) (Xgrip109) (x109p) tubgcp3 Xenopus laevis (African clawed frog) 906 microtubule nucleation [GO:0007020] GO:0000922; GO:0005737; GO:0005815; GO:0005874; GO:0007020 0 0 0 PF04130; P05090 CHOYP_LOC100876114.2.2 m.12304 sp APOD_HUMAN 37.086 151 88 5 16 165 41 185 8.01E-18 79.7 APOD_HUMAN reviewed Apolipoprotein D (Apo-D) (ApoD) APOD Homo sapiens (Human) 189 aging [GO:0007568]; angiogenesis [GO:0001525]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246] GO:0000302; GO:0001525; GO:0005319; GO:0005576; GO:0005615; GO:0005783; GO:0006006; GO:0006629; GO:0007420; GO:0007568; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0042493; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405 0 0 0 PF08212; Q0VD31 CHOYP_NAEGRDRAFT_47557.1.1 m.11283 sp FBXL4_BOVIN 24.444 180 102 5 7 152 53 232 8.01E-11 62.4 FBXL4_BOVIN reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) FBXL4 Bos taurus (Bovine) 621 0 GO:0005634; GO:0005758 0 0 0 PF00646; Q13231 CHOYP_BRAFLDRAFT_281651.6.8 m.44558 sp CHIT1_HUMAN 46.526 475 230 8 45 514 10 465 8.01E-144 431 CHIT1_HUMAN reviewed Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1) CHIT1 Homo sapiens (Human) 466 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032]; immune response [GO:0006955]; polysaccharide catabolic process [GO:0000272]; response to bacterium [GO:0009617] GO:0000272; GO:0004553; GO:0004568; GO:0005576; GO:0005615; GO:0005764; GO:0005975; GO:0006032; GO:0006955; GO:0008061; GO:0008843; GO:0009617 0 0 0 PF01607;PF00704; Q3U1T9 CHOYP_LOC100167728.1.2 m.2289 sp DEN1B_MOUSE 43.165 139 74 1 5 143 277 410 8.01E-28 120 DEN1B_MOUSE reviewed DENN domain-containing protein 1B (Connecdenn 2) Dennd1b Mus musculus (Mouse) 766 endocytic recycling [GO:0032456]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]; T-helper 2 cell cytokine production [GO:0035745] GO:0005829; GO:0015031; GO:0017112; GO:0017137; GO:0030136; GO:0032456; GO:0035745; GO:0043547; GO:0050776; GO:0050852 0 0 0 PF03455;PF02141;PF03456; Q4UMH6 CHOYP_LOC753665.2.2 m.63593 sp Y381_RICFE 23.009 339 236 8 303 641 737 1050 8.01E-17 88.6 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q6DRG7 CHOYP_MYPT1.2.2 m.56464 sp MYPT1_DANRE 57.547 106 39 2 47 148 946 1049 8.01E-24 99.4 MYPT1_DANRE reviewed Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) ppp1r12a mbs mypt1 si:dkey-28j4.1 zgc:110448 Danio rerio (Zebrafish) (Brachydanio rerio) 1049 actin filament bundle assembly [GO:0051017]; actin filament bundle distribution [GO:0070650]; convergent extension involved in axis elongation [GO:0060028]; liver development [GO:0001889]; midbrain-hindbrain boundary morphogenesis [GO:0021555]; regulation of cell adhesion [GO:0030155]; regulation of cell shape [GO:0008360]; regulation of myosin-light-chain-phosphatase activity [GO:0035507] GO:0001889; GO:0008360; GO:0019208; GO:0021555; GO:0030018; GO:0030155; GO:0031672; GO:0035507; GO:0046982; GO:0051017; GO:0060028; GO:0070650; GO:0071889; GO:0072357 0 0 0 PF12796;PF15898; Q80X90 CHOYP_FLNA.6.6 m.37383 sp FLNB_MOUSE 28.24 1551 950 47 22 1457 12 1514 8.01E-133 460 FLNB_MOUSE reviewed Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) Flnb Mus musculus (Mouse) 2602 actin cytoskeleton organization [GO:0030036]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; skeletal muscle tissue development [GO:0007519] GO:0001725; GO:0003334; GO:0003382; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0005938; GO:0007519; GO:0030018; GO:0030036; GO:0042802; GO:0044822; GO:0070062 0 0 0 PF00307;PF00630; Q8HXD5 CHOYP_RNF220.1.1 m.48993 sp RN220_MACFA 38.382 581 279 22 35 562 10 564 8.01E-92 296 RN220_MACFA reviewed E3 ubiquitin-protein ligase RNF220 (EC 6.3.2.-) (RING finger protein 220) RNF220 QflA-23520 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 566 positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0008270; GO:0016567; GO:0016874; GO:0051865; GO:0090263 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF15926; Q8QGW7 CHOYP_BCL3.2.2 m.57487 sp LITAF_CHICK 43.791 153 68 6 3 152 11 148 8.01E-25 95.9 LITAF_CHICK reviewed Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (LPS-induced TNF-alpha factor homolog) (Small integral membrane protein of lysosome/late endosome) LITAF SIMPLE Gallus gallus (Chicken) 148 "cytokine production [GO:0001816]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]; transcription, DNA-templated [GO:0006351]" GO:0001816; GO:0005125; GO:0005765; GO:0006351; GO:0006355; GO:0019953 0 0 0 PF10601; Q9R1F8 CHOYP_TLR22.2.3 m.51947 sp TLR2_CRIGR 26.12 781 444 34 57 738 27 773 8.01E-38 155 TLR2_CRIGR reviewed Toll-like receptor 2 (CD antigen CD282) TLR2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 784 cellular response to diacyl bacterial lipopeptide [GO:0071726]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of inflammatory response [GO:0050729]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 2 signaling pathway [GO:0034134] GO:0002755; GO:0004888; GO:0005794; GO:0006954; GO:0016021; GO:0030670; GO:0034134; GO:0045087; GO:0045121; GO:0050707; GO:0050729; GO:0071726; GO:0071727 0 0 0 PF13855;PF01463;PF01582; Q9S9V0 CHOYP_LOC100728625.2.2 m.51928 sp CDPKV_ARATH 31.25 128 87 1 40 166 337 464 8.01E-12 65.9 CDPKV_ARATH reviewed Calcium-dependent protein kinase 31 (EC 2.7.11.1) CPK31 At4g04695 T19J18.7 Arabidopsis thaliana (Mouse-ear cress) 484 abscisic acid-activated signaling pathway [GO:0009738]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; response to salicylic acid [GO:0009751] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0009738; GO:0009751; GO:0009931; GO:0016020; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; B2ZZS9 CHOYP_BRAFLDRAFT_69729.1.1 m.683 sp WDR55_ORYLA 44.745 333 178 3 69 395 46 378 8.02E-107 324 WDR55_ORYLA reviewed WD repeat-containing protein 55 (Protein hokecha) wdr55 Oryzias latipes (Japanese rice fish) (Japanese killifish) 400 eye development [GO:0001654]; head development [GO:0060322]; liver development [GO:0001889]; pharynx development [GO:0060465]; rRNA processing [GO:0006364]; spleen development [GO:0048536]; thymus development [GO:0048538] GO:0001654; GO:0001889; GO:0005730; GO:0006364; GO:0048536; GO:0048538; GO:0060322; GO:0060465 0 0 0 0 O42387 CHOYP_RPS24.3.8 m.5448 sp RS24_TAKRU 82.418 91 16 0 25 115 6 96 8.02E-55 170 RS24_TAKRU reviewed 40S ribosomal protein S24 rps24 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 132 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; translation [GO:0006412]" GO:0000166; GO:0000462; GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01282; O70277 CHOYP_BRAFLDRAFT_88223.19.22 m.62411 sp TRIM3_RAT 27.413 259 145 11 384 613 499 743 8.02E-12 72 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P08953 CHOYP_TOLL5A.1.1 m.40132 sp TOLL_DROME 25.036 699 397 31 68 685 344 996 8.02E-31 133 TOLL_DROME reviewed Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) 1097 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cell adhesion [GO:0007155]; defense response [GO:0006952]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; dorsal/ventral axis specification [GO:0009950]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; mitotic cytokinesis [GO:0000281]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; regulation of hemocyte differentiation [GO:0045610]; regulation of melanization defense response [GO:0035007]; response to bacterium [GO:0009617]; response to fungus [GO:0009620]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]; zygotic specification of dorsal/ventral axis [GO:0007352] GO:0000281; GO:0002229; GO:0004888; GO:0005737; GO:0005769; GO:0005886; GO:0006952; GO:0006955; GO:0006963; GO:0006967; GO:0007155; GO:0007352; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009617; GO:0009620; GO:0009880; GO:0009897; GO:0009950; GO:0009986; GO:0016021; GO:0016201; GO:0019730; GO:0019732; GO:0019955; GO:0030097; GO:0032154; GO:0035007; GO:0035172; GO:0042802; GO:0043234; GO:0045087; GO:0045610; GO:0045944; GO:0050830; GO:0050832; GO:0070976; GO:1902875 0 0 0 PF00560;PF13306;PF13855;PF01462;PF01582; P16157 CHOYP_AFUA_1G01020.35.50 m.43186 sp ANK1_HUMAN 32.927 328 191 3 38 351 341 653 8.02E-42 159 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q58EK5 CHOYP_DUOX1.1.4 m.14284 sp TDRD1_DANRE 25.087 861 512 28 1935 2723 195 994 8.02E-51 202 TDRD1_DANRE reviewed Tudor domain-containing protein 1 tdrd1 im:7155161 Danio rerio (Zebrafish) (Brachydanio rerio) 1175 DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; P granule organization [GO:0030719]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0005737; GO:0007281; GO:0007283; GO:0030719; GO:0031047; GO:0034584; GO:0034587; GO:0043046; GO:0043186; GO:0046872; GO:0051321; GO:0071546 0 0 0 PF00567;PF01753; Q5ZKV9 CHOYP_LOC100372926.2.3 m.61795 sp VPS50_CHICK 51.81 525 209 10 1 498 442 949 8.02E-173 514 VPS50_CHICK reviewed Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) VPS50 CCDC132 RCJMB04_8p23 Gallus gallus (Chicken) 949 endocytic recycling [GO:0032456]; protein transport [GO:0015031] GO:0015031; GO:0032456; GO:0055037; GO:1990745 0 0 0 PF10474;PF10475; Q861W0 CHOYP_LOC101170284.1.1 m.60282 sp IKBL1_PANTR 24.438 356 228 12 13 343 41 380 8.02E-19 89.7 IKBL1_PANTR reviewed NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) NFKBIL1 IKBL Pan troglodytes (Chimpanzee) 380 cellular response to lipopolysaccharide [GO:0071222]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor production [GO:0032720] GO:0005634; GO:0007249; GO:0031665; GO:0032088; GO:0032720; GO:0034122; GO:0071222 0 0 0 0 Q95VY2 CHOYP_SCHCODRAFT_63192.1.1 m.60641 sp TCTP_BRABE 44.681 94 48 2 29 122 1 90 8.02E-22 87.8 TCTP_BRABE reviewed Translationally-controlled tumor protein homolog (TCTP) 0 Branchiostoma belcheri (Amphioxus) 169 0 GO:0005737 0 0 0 PF00838; Q98943 CHOYP_LOC752124.1.1 m.53426 sp CASP2_CHICK 34.259 108 71 0 403 510 3 110 8.02E-09 61.6 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9BYJ9 CHOYP_LOC100371022.1.1 m.51316 sp YTHD1_HUMAN 44.406 572 217 23 1 500 1 543 8.02E-129 389 YTHD1_HUMAN reviewed YTH domain-containing family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) YTHDF1 C20orf21 Homo sapiens (Human) 559 positive regulation of translational initiation [GO:0045948] GO:0005737; GO:0043022; GO:0044822; GO:0045948; GO:1990247 0 0 0 PF04146; Q9NQC3 CHOYP_LOC655520.2.2 m.14178 sp RTN4_HUMAN 55.376 186 83 0 200 385 1005 1190 8.02E-70 241 RTN4_HUMAN reviewed Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) RTN4 KIAA0886 NOGO My043 SP1507 Homo sapiens (Human) 1192 apoptotic process [GO:0006915]; axonal fasciculation [GO:0007413]; cardiac epithelial to mesenchymal transition [GO:0060317]; cerebral cortex radial glia guided migration [GO:0021801]; endoplasmic reticulum tubular network assembly [GO:0071787]; endoplasmic reticulum tubular network organization [GO:0071786]; negative regulation of axon extension [GO:0030517]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell growth [GO:0030308]; nuclear pore complex assembly [GO:0051292]; regulation of apoptotic process [GO:0042981]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of cell migration [GO:0030334] GO:0005622; GO:0005635; GO:0005783; GO:0005789; GO:0005886; GO:0005913; GO:0006915; GO:0007413; GO:0021801; GO:0030176; GO:0030308; GO:0030334; GO:0030517; GO:0042981; GO:0042995; GO:0044822; GO:0050771; GO:0051292; GO:0060317; GO:0070062; GO:0071786; GO:0071787; GO:0098641; GO:2000172 0 0 0 PF02453; A4IF63 CHOYP_BRAFLDRAFT_87328.1.2 m.33078 sp TRIM2_BOVIN 24.409 127 92 1 23 145 618 744 8.03E-08 53.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E1BGN7 CHOYP_LOC100567354.2.2 m.20975 sp CGAS_BOVIN 28.173 323 202 14 260 561 164 477 8.03E-22 102 CGAS_BOVIN reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) MB21D1 Bos taurus (Bovine) 498 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; O01369 CHOYP_RPS27L.1.1 m.21535 sp QCR7_FASHE 39.175 97 59 0 48 144 25 121 8.03E-19 79.7 QCR7_FASHE reviewed Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (Ubiquinol-cytochrome c reductase complex 14 kDa protein) UBCRBP Fasciola hepatica (Liver fluke) 130 "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]" GO:0005750; GO:0006122 0 0 0 PF02271; P04323 CHOYP_LOC100695950.5.6 m.17942 sp POL3_DROME 34.653 101 62 2 37 137 149 245 8.03E-09 56.6 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P41731 CHOYP_SMG9.1.1 m.2907 sp CD63_MOUSE 39.231 130 79 0 2 131 3 132 8.03E-22 92 CD63_MOUSE reviewed CD63 antigen (CD antigen CD63) Cd63 Mus musculus (Mouse) 238 cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cellular protein localization [GO:0034613]; endosome to melanosome transport [GO:0035646]; epithelial cell differentiation [GO:0030855]; negative regulation of epithelial cell migration [GO:0010633]; pigmentation [GO:0043473]; pigment cell differentiation [GO:0050931]; pigment granule maturation [GO:0048757]; positive regulation of cell adhesion [GO:0045785]; positive regulation of endocytosis [GO:0045807]; positive regulation of integrin-mediated signaling pathway [GO:2001046]; positive regulation of receptor internalization [GO:0002092]; protein transport [GO:0015031]; regulation of rubidium ion transport [GO:2000680]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746] GO:0002092; GO:0005615; GO:0005764; GO:0005765; GO:0005770; GO:0005887; GO:0007155; GO:0007160; GO:0009986; GO:0010008; GO:0010633; GO:0015031; GO:0016477; GO:0030855; GO:0031226; GO:0031902; GO:0031904; GO:0032585; GO:0034613; GO:0035646; GO:0042470; GO:0043234; GO:0043473; GO:0045785; GO:0045807; GO:0048757; GO:0050931; GO:0070062; GO:0097487; GO:1900746; GO:2000680; GO:2001046 0 0 0 PF00335; P49746 CHOYP_LOC100367144.1.1 m.34153 sp TSP3_HUMAN 43.769 658 338 11 2049 2691 298 938 8.03E-151 499 TSP3_HUMAN reviewed Thrombospondin-3 THBS3 TSP3 Homo sapiens (Human) 956 bone trabecula formation [GO:0060346]; cell-matrix adhesion [GO:0007160]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931] GO:0003417; GO:0005509; GO:0005576; GO:0007160; GO:0008201; GO:0043931; GO:0048471; GO:0060346 0 0 0 PF11598;PF07645;PF02412;PF05735; P98161 CHOYP_LOC100375380.4.4 m.54849 sp PKD1_HUMAN 23.223 422 267 16 141 553 1244 1617 8.03E-08 59.3 PKD1_HUMAN reviewed Polycystin-1 (Autosomal dominant polycystic kidney disease 1 protein) PKD1 Homo sapiens (Human) 4303 anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium-independent cell-matrix adhesion [GO:0007161]; calcium ion transmembrane transport [GO:0070588]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell cycle arrest [GO:0007050]; cell-matrix adhesion [GO:0007160]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of cell polarity [GO:0030010]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; JAK-STAT cascade [GO:0007259]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; neural tube development [GO:0021915]; nitrogen compound metabolic process [GO:0006807]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [GO:0031659]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein export from nucleus [GO:0006611]; regulation of cell adhesion [GO:0030155]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; single organismal cell-cell adhesion [GO:0016337]; skin development [GO:0043588]; spinal cord development [GO:0021510] GO:0000139; GO:0001502; GO:0001701; GO:0001822; GO:0001889; GO:0001892; GO:0002133; GO:0005262; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005929; GO:0006611; GO:0006807; GO:0007050; GO:0007156; GO:0007160; GO:0007161; GO:0007204; GO:0007259; GO:0007507; GO:0009653; GO:0009986; GO:0016021; GO:0016323; GO:0016328; GO:0016337; GO:0018105; GO:0019901; GO:0019904; GO:0021510; GO:0021915; GO:0030010; GO:0030155; GO:0030246; GO:0030660; GO:0031512; GO:0031659; GO:0032092; GO:0034405; GO:0036303; GO:0042994; GO:0043588; GO:0044325; GO:0045944; GO:0048565; GO:0048754; GO:0048806; GO:0050982; GO:0051216; GO:0060170; GO:0060236; GO:0060428; GO:0060674; GO:0061136; GO:0070062; GO:0070588; GO:0072164; GO:0072177; GO:0072205; GO:0072218; GO:0072237; GO:0072287; GO:0072372 0 0 0 PF00059;PF13855;PF00801;PF08016;PF01477;PF02010;PF01822; Q00PJ1 CHOYP_TVAG_473500.1.1 m.54158 sp CTTB2_ATEAB 36.306 157 95 2 364 515 691 847 8.03E-22 103 CTTB2_ATEAB reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Atelerix albiventris (Middle-African hedgehog) (Four-toed hedgehog) 1654 0 GO:0005938; GO:0043197 0 0 0 PF12796;PF09727; Q01085 CHOYP_LOC100168260.1.1 m.63985 sp TIAR_HUMAN 50.699 286 108 7 89 372 77 331 8.03E-84 263 TIAR_HUMAN reviewed Nucleolysin TIAR (TIA-1-related protein) TIAL1 Homo sapiens (Human) 375 apoptotic process [GO:0006915]; defense response [GO:0006952]; fibroblast growth factor receptor signaling pathway [GO:0008543]; germ cell development [GO:0007281]; positive regulation of cell proliferation [GO:0008284]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; stem cell division [GO:0017145] GO:0000166; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0005764; GO:0006357; GO:0006915; GO:0006952; GO:0007281; GO:0008284; GO:0008543; GO:0010494; GO:0017091; GO:0017145; GO:0044822; GO:0070062 0 0 0 PF00076; Q13489 CHOYP_LOC726172.1.1 m.46832 sp BIRC3_HUMAN 29.947 187 120 4 472 656 23 200 8.03E-16 84.7 BIRC3_HUMAN reviewed Baculoviral IAP repeat-containing protein 3 (EC 6.3.2.-) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (TNFR2-TRAF-signaling complex protein 1) BIRC3 API2 MIHC RNF49 Homo sapiens (Human) 604 cell surface receptor signaling pathway [GO:0007166]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; protein heterooligomerization [GO:0051291]; regulation of apoptotic process [GO:0042981]; regulation of cysteine-type endopeptidase activity [GO:2000116]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of necroptotic process [GO:0060544]; regulation of necrotic cell death [GO:0010939]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; regulation of RIG-I signaling pathway [GO:0039535]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; spermatogenesis [GO:0007283]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007166; GO:0007249; GO:0007283; GO:0008270; GO:0010803; GO:0010939; GO:0016740; GO:0016874; GO:0031398; GO:0033209; GO:0034121; GO:0035666; GO:0038061; GO:0039535; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043234; GO:0045088; GO:0045121; GO:0050727; GO:0051291; GO:0060544; GO:0060546; GO:0070424; GO:1990001; GO:2000116 0 0 0 PF00653;PF00619; Q3UQI9 CHOYP_F188B.1.1 m.8460 sp F188B_MOUSE 41.016 768 376 23 1 715 1 744 8.03E-163 490 F188B_MOUSE reviewed Probable ubiquitin carboxyl-terminal hydrolase FAM188B (EC 3.4.19.12) Fam188b Mus musculus (Mouse) 744 0 0 0 0 0 PF13898; Q5IS61 CHOYP_LOC100370299.2.2 m.65414 sp OPCM_PANTR 23.669 169 110 7 2 165 73 227 8.03E-07 51.2 OPCM_PANTR reviewed Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) OPCML OBCAM Pan troglodytes (Chimpanzee) 345 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225; GO:0070062 0 0 0 PF07679; Q5ZLF0 CHOYP_F10A1.1.4 m.11464 sp F10A1_CHICK 65.217 69 23 1 51 119 294 361 8.03E-23 94.4 F10A1_CHICK reviewed Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) ST13 FAM10A1 RCJMB04_6h13 Gallus gallus (Chicken) 361 0 GO:0005737 0 0 0 PF13181; Q68F99 CHOYP_LOC657604.1.1 m.43994 sp STAC3_XENTR 41.88 117 67 1 326 442 222 337 8.03E-25 107 STAC3_XENTR reviewed SH3 and cysteine-rich domain-containing protein 3 stac3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 337 intracellular signal transduction [GO:0035556]; neuromuscular synaptic transmission [GO:0007274]; skeletal muscle contraction [GO:0003009]; skeletal muscle tissue development [GO:0007519] GO:0003009; GO:0005622; GO:0007274; GO:0007519; GO:0035556; GO:0046872 0 0 0 PF00130;PF07653;PF14604; Q6AZN4 CHOYP_LOC663755.1.1 m.11019 sp RM15_XENLA 50.526 285 141 0 5 289 10 294 8.03E-94 282 RM15_XENLA reviewed "39S ribosomal protein L15, mitochondrial (L15mt) (MRP-L15)" mrpl15 Xenopus laevis (African clawed frog) 296 translation [GO:0006412] GO:0003735; GO:0005739; GO:0006412; GO:0015934 0 0 0 PF00828; Q6IE52 CHOYP_MUG2.1.1 m.55656 sp MUG2_RAT 26.624 1555 913 50 4 1452 11 1443 8.03E-114 396 MUG2_RAT reviewed Murinoglobulin-2 Mug2 Rattus norvegicus (Rat) 1448 0 GO:0004867; GO:0005615 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q6MG64 CHOYP_BRAFLDRAFT_63397.5.8 m.28525 sp VWA7_RAT 27.686 484 314 15 51 525 26 482 8.03E-41 162 VWA7_RAT reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) 892 0 GO:0005576 0 0 0 0 Q7ZVZ7 CHOYP_ISCW_ISCW010150.1.2 m.11303 sp AB17C_DANRE 77.778 288 63 1 1 288 8 294 8.03E-177 492 AB17C_DANRE reviewed Protein ABHD17C (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 17C) (Abhydrolase domain-containing protein 17C) abhd17c zgc:55468 Danio rerio (Zebrafish) (Brachydanio rerio) 294 0 GO:0016787 0 0 0 PF12146; Q7ZVZ7 CHOYP_ISCW_ISCW010150.2.2 m.48553 sp AB17C_DANRE 77.778 288 63 1 1 288 8 294 8.03E-177 492 AB17C_DANRE reviewed Protein ABHD17C (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 17C) (Abhydrolase domain-containing protein 17C) abhd17c zgc:55468 Danio rerio (Zebrafish) (Brachydanio rerio) 294 0 GO:0016787 0 0 0 PF12146; O42115 CHOYP_LOC100366437.1.1 m.11653 sp ARX_DANRE 60.169 118 37 3 71 180 170 285 8.04E-32 126 ARX_DANRE reviewed Aristaless-related homeobox protein (ARX) arx Danio rerio (Zebrafish) (Brachydanio rerio) 453 "neuron development [GO:0048666]; pancreatic A cell development [GO:0003322]; regulation of transcription, DNA-templated [GO:0006355]; subthalamus development [GO:0021539]; transcription, DNA-templated [GO:0006351]" GO:0003322; GO:0005634; GO:0006351; GO:0006355; GO:0021539; GO:0043565; GO:0048666 0 0 0 PF00046;PF03826; O42358 CHOYP_RX2.1.1 m.37996 sp RX3_DANRE 48.558 208 81 7 71 261 94 292 8.04E-54 178 RX3_DANRE reviewed Retinal homeobox protein Rx3 rx3 Danio rerio (Zebrafish) (Brachydanio rerio) 292 "adenohypophysis development [GO:0021984]; camera-type eye morphogenesis [GO:0048593]; cell fate specification [GO:0001708]; embryonic camera-type eye morphogenesis [GO:0048596]; eye development [GO:0001654]; eye field cell fate commitment involved in camera-type eye formation [GO:0060898]; forebrain development [GO:0030900]; neural crest cell migration [GO:0001755]; regulation of transcription, DNA-templated [GO:0006355]; retina development in camera-type eye [GO:0060041]; transcription, DNA-templated [GO:0006351]" GO:0001654; GO:0001708; GO:0001755; GO:0005634; GO:0006351; GO:0006355; GO:0021984; GO:0030900; GO:0043565; GO:0048593; GO:0048596; GO:0060041; GO:0060898 0 0 0 PF00046;PF03826; O88799 CHOYP_contig_050401 m.59958 sp ZAN_MOUSE 30.569 422 220 17 460 853 560 936 8.04E-06 54.7 ZAN_MOUSE reviewed Zonadhesin Zan Mus musculus (Mouse) 5376 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155]; regulation of binding of sperm to zona pellucida [GO:2000359] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840; GO:2000359 0 0 cd06263; PF00629;PF01826;PF12714;PF00094; P28828 CHOYP_PTPRG.2.3 m.61939 sp PTPRM_MOUSE 34.75 541 331 11 814 1338 918 1452 8.04E-86 311 PTPRM_MOUSE reviewed Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48) Ptprm Kiaa4044 Mus musculus (Mouse) 1452 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of vasodilation [GO:0045909]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165] GO:0001937; GO:0004725; GO:0005001; GO:0005737; GO:0005911; GO:0005913; GO:0006470; GO:0007156; GO:0007165; GO:0010596; GO:0010842; GO:0016021; GO:0016525; GO:0030027; GO:0031175; GO:0031290; GO:0042493; GO:0042802; GO:0045296; GO:0045909; GO:0048471 0 0 cd06263; PF00041;PF00047;PF00629;PF00102; Q55GU0 CHOYP_LOC100382522.1.2 m.52200 sp Y9955_DICDI 40.107 187 94 6 859 1042 657 828 8.04E-27 122 Y9955_DICDI reviewed Probable serine/threonine-protein kinase DDB_G0267514 (EC 2.7.11.1) DDB_G0267514 Dictyostelium discoideum (Slime mold) 916 0 GO:0004674; GO:0005524 0 0 0 PF07714; Q5BIM1 CHOYP_TVAG_127540.5.10 m.46598 sp TRI45_BOVIN 30.657 137 86 5 1 133 123 254 8.04E-07 51.2 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5RCM7 CHOYP_DJC16.1.1 m.11785 sp DJC16_PONAB 39.044 251 137 5 51 295 7 247 8.04E-50 179 DJC16_PONAB reviewed DnaJ homolog subfamily C member 16 DNAJC16 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 782 cell redox homeostasis [GO:0045454] GO:0005623; GO:0016021; GO:0045454 0 0 cd06257; PF00226;PF00085; Q6NZL8 CHOYP_SCUBE2.1.1 m.19560 sp SCUB1_MOUSE 43.537 147 78 5 33 177 307 450 8.04E-24 105 SCUB1_MOUSE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 1" Scube1 Mus musculus (Mouse) 1018 protein homooligomerization [GO:0051260] GO:0005509; GO:0005615; GO:0009897; GO:0009986; GO:0019897; GO:0046982; GO:0051260 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q8N6F8 CHOYP_BRAFLDRAFT_121459.1.1 m.21810 sp WBS27_HUMAN 33.333 168 107 3 48 215 31 193 8.04E-28 109 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q8R3V6 CHOYP_BRAFLDRAFT_131608.1.1 m.44249 sp CUED1_MOUSE 50.602 83 33 2 40 114 34 116 8.04E-14 77 CUED1_MOUSE reviewed CUE domain-containing protein 1 Cuedc1 Mus musculus (Mouse) 388 0 0 0 0 0 PF02845; Q8VCC1 CHOYP_LOC100700303.1.1 m.19969 sp PGDH_MOUSE 35.887 248 152 3 1 241 1 248 8.04E-53 175 PGDH_MOUSE reviewed 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH) (EC 1.1.1.141) (Prostaglandin dehydrogenase 1) Hpgd Pgdh1 Mus musculus (Mouse) 269 ductus arteriosus closure [GO:0097070]; female pregnancy [GO:0007565]; negative regulation of cell cycle [GO:0045786]; ovulation [GO:0030728]; parturition [GO:0007567]; prostaglandin metabolic process [GO:0006693]; thrombin receptor signaling pathway [GO:0070493]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0003824; GO:0004957; GO:0005654; GO:0005737; GO:0006693; GO:0007179; GO:0007565; GO:0007567; GO:0016323; GO:0016404; GO:0030728; GO:0045786; GO:0051287; GO:0070062; GO:0070403; GO:0070493; GO:0097070 0 0 0 PF00106; Q92010 CHOYP_LOC100564140.1.2 m.5698 sp ZBT14_CHICK 41.6 125 65 1 9 133 322 438 8.04E-24 102 ZBT14_CHICK reviewed Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 5) (ZF5) ZBTB14 ZFP161 Gallus gallus (Chicken) 448 "negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0043565; GO:0044212; GO:0045892; GO:0046872 0 0 0 PF00651;PF00096; Q9C098 CHOYP_BRAFLDRAFT_71623.1.2 m.21140 sp DCLK3_HUMAN 64.419 267 95 0 614 880 351 617 8.04E-117 374 DCLK3_HUMAN reviewed Serine/threonine-protein kinase DCLK3 (EC 2.7.11.1) (Doublecortin domain-containing protein 3C) (Doublecortin-like and CAM kinase-like 3) (Doublecortin-like kinase 3) DCLK3 DCAMKL3 DCDC3C KIAA1765 Homo sapiens (Human) 648 0 GO:0004674; GO:0005524; GO:0005634; GO:0005737 0 0 0 PF00069; Q9ESN6 CHOYP_TRIM3.29.58 m.32914 sp TRIM2_MOUSE 27.551 196 124 7 145 332 536 721 8.04E-10 63.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H8W5 CHOYP_LOC100376215.4.19 m.24528 sp TRI45_HUMAN 24.476 286 194 9 10 279 115 394 8.04E-09 62 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9UJW7 CHOYP_LOC100482057.1.1 m.51546 sp ZN229_HUMAN 32.335 334 196 8 282 608 398 708 8.04E-41 162 ZN229_HUMAN reviewed Zinc finger protein 229 ZNF229 Homo sapiens (Human) 825 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; C9JQI7 CHOYP_BRAFLDRAFT_104097.1.1 m.60571 sp TM232_HUMAN 32.267 375 202 6 1 370 3 330 8.05E-48 184 TM232_HUMAN reviewed Transmembrane protein 232 TMEM232 Homo sapiens (Human) 657 0 GO:0016021 0 0 0 PF15877; O88382 CHOYP_MAGI1.1.1 m.66921 sp MAGI2_RAT 40.313 702 311 13 4 640 106 764 8.05E-142 467 MAGI2_RAT reviewed "Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Atrophin-1-interacting protein 1) (AIP-1) (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Synaptic-scaffolding molecule) (S-SCAM)" Magi2 Acvrinp1 Aip1 Sscam Rattus norvegicus (Rat) 1277 cellular response to nerve growth factor stimulus [GO:1990090]; glomerular filtration [GO:0003094]; glomerular visceral epithelial cell development [GO:0072015]; mitotic cell cycle arrest [GO:0071850]; negative regulation of activin receptor signaling pathway [GO:0032926]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein kinase B signaling [GO:0051898]; nerve growth factor signaling pathway [GO:0038180]; positive regulation of neuron projection development [GO:0010976]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of receptor internalization [GO:0002092]; protein heterooligomerization [GO:0051291]; receptor clustering [GO:0043113]; SMAD protein signal transduction [GO:0060395] GO:0002092; GO:0003094; GO:0004871; GO:0005634; GO:0005737; GO:0005770; GO:0005886; GO:0005923; GO:0008285; GO:0010976; GO:0014069; GO:0019902; GO:0030159; GO:0030336; GO:0030425; GO:0031697; GO:0032403; GO:0032516; GO:0032926; GO:0036057; GO:0038180; GO:0043113; GO:0043234; GO:0045202; GO:0046332; GO:0048471; GO:0051291; GO:0051898; GO:0060395; GO:0070699; GO:0071850; GO:0072015; GO:1990090 0 0 0 PF00625;PF00595;PF00397; P46087 CHOYP_LOC582075.1.1 m.44478 sp NOP2_HUMAN 34.375 160 74 5 418 549 127 283 8.05E-17 87.8 NOP2_HUMAN reviewed Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120) NOP2 NOL1 NSUN1 Homo sapiens (Human) 812 maturation of LSU-rRNA [GO:0000470]; positive regulation of cell proliferation [GO:0008284]; rRNA base methylation [GO:0070475] GO:0000470; GO:0005730; GO:0008284; GO:0009383; GO:0044822; GO:0070475 0 0 0 PF01189;PF17125;PF08062; P54269 CHOYP_IRO.4.4 m.24034 sp CAUP_DROME 58.482 224 70 8 6 214 84 299 8.05E-66 228 CAUP_DROME reviewed Homeobox protein caupolican caup CG10605 Drosophila melanogaster (Fruit fly) 693 "compound eye morphogenesis [GO:0001745]; equator specification [GO:0045317]; imaginal disc-derived wing vein specification [GO:0007474]; muscle cell fate commitment [GO:0042693]; negative regulation of growth [GO:0045926]; phagocytosis [GO:0006909]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of mitotic cell cycle [GO:0007346]; transcription, DNA-templated [GO:0006351]" GO:0001745; GO:0003700; GO:0003705; GO:0005634; GO:0006351; GO:0006909; GO:0007346; GO:0007474; GO:0042693; GO:0043565; GO:0045317; GO:0045926; GO:0045944 0 0 0 PF05920; P54923 CHOYP_BRAFLDRAFT_212086.11.11 m.65220 sp ADPRH_MOUSE 56.918 318 132 3 2 318 43 356 8.05E-115 339 ADPRH_MOUSE reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) Adprh Arh1 Mus musculus (Mouse) 362 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q2KJ16 CHOYP_LOC100117602.1.1 m.23340 sp PHKG2_BOVIN 54.43 158 72 0 1 158 1 158 8.05E-56 182 PHKG2_BOVIN reviewed "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-2)" PHKG2 Bos taurus (Bovine) 406 glycogen biosynthetic process [GO:0005978] GO:0004689; GO:0005524; GO:0005964; GO:0005978 0 0 0 PF00069; Q5JVG2 CHOYP_ZN549.1.1 m.8370 sp ZN484_HUMAN 32.249 369 209 15 96 458 409 742 8.05E-33 137 ZN484_HUMAN reviewed Zinc finger protein 484 ZNF484 Homo sapiens (Human) 852 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q6DIB5 CHOYP_CED1.3.29 m.19893 sp MEG10_MOUSE 35.379 277 158 13 1 272 182 442 8.05E-34 138 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6GL42 CHOYP_TM39A.1.1 m.23508 sp TM39A_XENTR 40.286 489 242 9 30 475 1 482 8.05E-108 332 TM39A_XENTR reviewed Transmembrane protein 39A tmem39a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 488 0 GO:0016021 0 0 0 PF10271; Q99715 CHOYP_LOC100709262.2.2 m.61239 sp COCA1_HUMAN 37.838 74 46 0 3 76 161 234 8.05E-09 55.8 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q9C882 CHOYP_MYH6.1.1 m.34610 sp GTL1_ARATH 33.333 87 58 0 121 207 436 522 8.05E-06 50.8 GTL1_ARATH reviewed Trihelix transcription factor GTL1 (GT2-LIKE protein 1) (AtGTL1) (Protein GT-2-LIKE1) (Trihelix DNA-binding protein GTL1) GTL1 At1g33240 T16O9.10 T9L6.10 Arabidopsis thaliana (Mouse-ear cress) 587 "cellular response to water deprivation [GO:0042631]; negative regulation of cell growth [GO:0030308]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of cell size [GO:0008361]; regulation of stomatal complex development [GO:2000038]; regulation of stomatal complex patterning [GO:2000037]; response to water deprivation [GO:0009414]; transcription, DNA-templated [GO:0006351]; trichome morphogenesis [GO:0010090]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0008361; GO:0009414; GO:0010090; GO:0030308; GO:0032876; GO:0042631; GO:0043565; GO:0045892; GO:2000037; GO:2000038 0 0 0 0 Q9ESN6 CHOYP_LOC100373444.22.79 m.26109 sp TRIM2_MOUSE 30.603 232 134 11 305 524 523 739 8.05E-13 74.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM2.16.59 m.31979 sp TRIM2_MOUSE 24.138 290 184 13 118 383 465 742 8.05E-10 64.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9UGM3 CHOYP_LOC757057.5.5 m.65001 sp DMBT1_HUMAN 39.009 464 177 10 11 447 1380 1764 8.05E-77 266 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9UPV7 CHOYP_LOC100340035.1.1 m.29491 sp PHF24_HUMAN 27.5 280 177 9 83 341 120 394 8.05E-24 104 PHF24_HUMAN reviewed PHD finger protein 24 PHF24 KIAA1045 Homo sapiens (Human) 400 0 GO:0005509 0 0 0 PF16744; E1BGN7 CHOYP_contig_056066 m.66649 sp CGAS_BOVIN 43.75 48 27 0 36 83 174 221 8.06E-06 48.1 CGAS_BOVIN reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) MB21D1 Bos taurus (Bovine) 498 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; P10079 CHOYP_SNED1.4.4 m.51856 sp FBP1_STRPU 47.115 624 286 5 234 816 203 823 8.06E-176 562 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P46436 CHOYP_LOC100863653.1.1 m.48164 sp GST1_ASCSU 28.906 128 88 1 6 130 76 203 8.06E-10 57.4 GST1_ASCSU reviewed Glutathione S-transferase 1 (EC 2.5.1.18) (GST class-sigma) GST1 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 206 oxidation-reduction process [GO:0055114] GO:0004364; GO:0004602; GO:0005737; GO:0005903; GO:0055114 0 0 0 PF14497;PF02798; P97564 CHOYP_LOC100373399.1.1 m.13288 sp GPAT1_RAT 35.985 792 472 19 100 863 44 828 8.06E-151 467 GPAT1_RAT reviewed "Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)" Gpam Gpat1 Rattus norvegicus (Rat) 828 CDP-diacylglycerol biosynthetic process [GO:0016024]; cellular response to insulin stimulus [GO:0032869]; positive regulation of triglyceride biosynthetic process [GO:0010867]; response to activity [GO:0014823]; response to cadmium ion [GO:0046686]; response to fructose [GO:0009750]; response to nutrient levels [GO:0031667] GO:0004366; GO:0005739; GO:0005741; GO:0005886; GO:0009750; GO:0010867; GO:0014823; GO:0016021; GO:0016024; GO:0031667; GO:0031966; GO:0032869; GO:0046686 PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. 0 0 PF01553; Q06852 CHOYP_contig_027437 m.31154 sp SLAP1_CLOTH 30 410 197 15 2 391 1430 1769 8.06E-09 61.2 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q24157 CHOYP_LOC661418.1.1 m.59470 sp BRN_DROME 35.366 246 145 4 178 416 80 318 8.06E-46 164 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q3B7D5 CHOYP_LOC100119694.1.1 m.52143 sp RASF2_RAT 32.132 333 176 7 173 492 22 317 8.06E-36 139 RASF2_RAT reviewed Ras association domain-containing protein 2 Rassf2 Rattus norvegicus (Rat) 326 cell cycle [GO:0007049]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165] GO:0000776; GO:0000777; GO:0005634; GO:0005737; GO:0007049; GO:0007165; GO:0042981 0 0 0 PF16517;PF00788; Q3UGM2 CHOYP_LOC591209.1.1 m.64357 sp NEK10_MOUSE 35.294 85 52 1 30 114 1024 1105 8.06E-06 47.4 NEK10_MOUSE reviewed Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (Never in mitosis A-related kinase 10) (NimA-related protein kinase 10) Nek10 Gm282 Mus musculus (Mouse) 1111 chromosome segregation [GO:0007059]; microtubule-based process [GO:0007017]; protein phosphorylation [GO:0006468] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005813; GO:0006468; GO:0007017; GO:0007059; GO:0046872 0 0 0 PF00069; Q6AYL5 CHOYP_SF3B4.1.1 m.14985 sp SF3B4_RAT 87.736 212 26 0 1 212 1 212 8.06E-138 403 SF3B4_RAT reviewed Splicing factor 3B subunit 4 Sf3b4 Rattus norvegicus (Rat) 424 "mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]" GO:0000166; GO:0005689; GO:0006397; GO:0008380; GO:0044822; GO:0048026 0 0 0 PF00076; Q6DHQ1 CHOYP_NEMVEDRAFT_V1G246569.1.1 m.28234 sp HVCN1_DANRE 35.938 128 76 2 181 305 103 227 8.06E-13 71.2 HVCN1_DANRE reviewed Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) hvcn1 zgc:92181 Danio rerio (Zebrafish) (Brachydanio rerio) 235 cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transport [GO:0015992] GO:0005887; GO:0015992; GO:0030171; GO:0071294; GO:0071467 0 0 0 PF00520; Q6P3R8 CHOYP_BRAFLDRAFT_63676.1.1 m.37146 sp NEK5_HUMAN 43.75 272 147 4 1 271 1 267 8.06E-81 268 NEK5_HUMAN reviewed Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5) NEK5 Homo sapiens (Human) 708 positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of striated muscle cell differentiation [GO:0051155]; protein phosphorylation [GO:0006468] GO:0004674; GO:0005524; GO:0006468; GO:0046872; GO:0051155; GO:2001056 0 0 0 PF00069; Q92733 CHOYP_PRCC.2.2 m.58572 sp PRCC_HUMAN 34.483 377 180 12 122 452 136 491 8.06E-43 160 PRCC_HUMAN reviewed Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) PRCC TPRC Homo sapiens (Human) 491 mitotic cell cycle checkpoint [GO:0007093] GO:0005634; GO:0007093 0 0 0 PF10253; Q96GP6 CHOYP_MEG10.5.91 m.13859 sp SREC2_HUMAN 40.964 166 85 6 240 401 236 392 8.06E-23 104 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9KPS0 CHOYP_LOC100122269.1.1 m.8408 sp BOLA_VIBCH 51 100 49 0 23 122 2 101 8.06E-32 111 BOLA_VIBCH reviewed DNA-binding transcriptional regulator BolA bolA VC_2296 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) 106 "regulation of cell shape [GO:0008360]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0006351; GO:0006355; GO:0008360 0 0 0 PF01722; Q9NWQ9 CHOYP_SI_CH211-14A17.11.1.1 m.18622 sp CN119_HUMAN 43.878 98 53 1 8 103 37 134 8.06E-25 94 CN119_HUMAN reviewed Uncharacterized protein C14orf119 C14orf119 My028 Homo sapiens (Human) 140 0 GO:0005739 0 0 0 PF14969; Q9QXW2 CHOYP_LOC412155.2.2 m.30381 sp FBXW5_MOUSE 38.095 168 102 2 27 193 9 175 8.06E-31 121 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9SVG0 CHOYP_LOC100183303.1.1 m.52096 sp ANTL2_ARATH 32.244 459 229 9 13 448 34 433 8.06E-54 189 ANTL2_ARATH reviewed Amino acid transporter ANTL2 (Aromatic and neutral amino acid transporter-like protein 2) At4g38250 F22I13.20 Arabidopsis thaliana (Mouse-ear cress) 436 amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865] GO:0003333; GO:0005886; GO:0006865; GO:0015171; GO:0016021 0 0 0 PF01490; Q9UDR5 CHOYP_LOC100123521.1.2 m.20656 sp AASS_HUMAN 50.14 357 178 0 1 357 560 916 8.06E-119 368 AASS_HUMAN reviewed "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Homo sapiens (Human) 926 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine catabolic process [GO:0006554]; protein tetramerization [GO:0051262] GO:0005739; GO:0005759; GO:0006554; GO:0033512; GO:0043231; GO:0047130; GO:0047131; GO:0051262 PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.; PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. 0 0 PF05222;PF16653;PF03435; B3EWZ3 CHOYP_BRAFLDRAFT_85664.10.10 m.45430 sp CADN_ACRMI 42.41 415 228 4 749 1154 159 571 8.07E-99 350 CADN_ACRMI reviewed Coadhesin (Fragment) 0 Acropora millepora (Staghorn coral) 1675 0 GO:0016021 0 0 0 PF00754;PF00090;PF00092; P24014 CHOYP_LRC15.1.3 m.17167 sp SLIT_DROME 30.357 336 182 9 19 319 571 889 8.07E-22 102 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P25799 CHOYP_CTU_17670.1.1 m.55281 sp NFKB1_MOUSE 27.586 174 113 5 778 949 527 689 8.07E-06 53.9 NFKB1_MOUSE reviewed Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] Nfkb1 Mus musculus (Mouse) 971 "apoptotic process [GO:0006915]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to carbohydrate stimulus [GO:0071322]; cellular response to cytokine stimulus [GO:0071345]; cellular response to diterpene [GO:1904630]; cellular response to dsRNA [GO:0071359]; cellular response to glucoside [GO:1904632]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to organic cyclic compound [GO:0071407]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to tumor necrosis factor [GO:0071356]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; innate immune response [GO:0045087]; lymph node development [GO:0048535]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcidiol 1-monooxygenase activity [GO:0010956]; negative regulation of cytokine production [GO:0001818]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-12 biosynthetic process [GO:0045083]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to copper ion [GO:0046688]; response to cytokine [GO:0034097]; response to muscle stretch [GO:0035994]; response to oxidative stress [GO:0006979]" GO:0000122; GO:0000975; GO:0000976; GO:0000977; GO:0000980; GO:0000981; GO:0001205; GO:0001227; GO:0001818; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006915; GO:0006979; GO:0007249; GO:0010956; GO:0033256; GO:0034097; GO:0035994; GO:0038061; GO:0042802; GO:0042803; GO:0042805; GO:0043005; GO:0043066; GO:0043565; GO:0044212; GO:0045083; GO:0045087; GO:0045892; GO:0045893; GO:0045944; GO:0046688; GO:0046982; GO:0048535; GO:0050728; GO:0071222; GO:0071260; GO:0071316; GO:0071322; GO:0071345; GO:0071347; GO:0071354; GO:0071356; GO:0071359; GO:0071375; GO:0071407; GO:0090263; GO:1900127; GO:1904630; GO:1904632; GO:1990416; GO:2000630 0 0 0 PF00023;PF12796;PF00531;PF16179;PF00554; Q10Q46 CHOYP_CYT5.1.1 m.29960 sp CYT6_ORYSJ 32.955 88 56 2 47 132 20 106 8.07E-09 53.9 CYT6_ORYSJ reviewed Cysteine proteinase inhibitor 6 (Oryzacystatin VI) (OC-VI) (Oryzacystatin-6) Os03g0210200 LOC_Os03g11180 Oryza sativa subsp. japonica (Rice) 113 defense response [GO:0006952] GO:0004869; GO:0005576; GO:0006952 0 0 0 PF16845; Q28983 CHOYP_FCGBP.4.4 m.57933 sp ZAN_PIG 36.8 375 200 12 48 412 1177 1524 8.07E-56 203 ZAN_PIG reviewed Zonadhesin ZAN Sus scrofa (Pig) 2476 binding of sperm to zona pellucida [GO:0007339]; cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0007339; GO:0016021; GO:0050840 0 0 cd06263; PF08742;PF00008;PF00629;PF01826;PF12714;PF00094; Q4R381 CHOYP_LOC100867952.2.2 m.50603 sp EZH2_MACFA 39.655 58 33 1 45 100 2 59 8.07E-08 52.4 EZH2_MACFA reviewed Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.43) (Enhancer of zeste homolog 2) EZH2 QtsA-15957 QtsA-18821 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 746 "histone H3-K27 methylation [GO:0070734]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of GTPase activity [GO:0043547]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0001047; GO:0003682; GO:0006351; GO:0010718; GO:0018024; GO:0035098; GO:0042752; GO:0043406; GO:0043547; GO:0045814; GO:0045892; GO:0048387; GO:0048511; GO:0070734; GO:0071902; GO:1990841 0 0 0 PF11616;PF00856; Q5PPV2 CHOYP_LOC100374062.1.1 m.22585 sp TEKT4_XENLA 53.626 455 199 3 1 452 1 446 8.07E-166 477 TEKT4_XENLA reviewed Tektin-4 tekt4 Xenopus laevis (African clawed frog) 446 0 GO:0005737; GO:0005874; GO:0005929 0 0 0 0 Q91XB0 CHOYP_LOC100377759.9.15 m.39318 sp TREX1_MOUSE 25 224 126 8 70 259 5 220 8.07E-08 56.6 TREX1_MOUSE reviewed Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III) Trex1 Mus musculus (Mouse) 314 cellular response to interferon-beta [GO:0035458]; DNA metabolic process [GO:0006259] GO:0003690; GO:0003697; GO:0005634; GO:0005789; GO:0005829; GO:0006259; GO:0008296; GO:0008408; GO:0008853; GO:0032405; GO:0032407; GO:0032558; GO:0035458; GO:0042803; GO:0046872 0 0 0 0 Q9BX66 CHOYP_LOC100867381.3.8 m.15890 sp SRBS1_HUMAN 31.03 709 334 31 406 1025 287 929 8.07E-55 213 SRBS1_HUMAN reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) 1292 cell-matrix adhesion [GO:0007160]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; muscle contraction [GO:0006936]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0003779; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005913; GO:0005915; GO:0005924; GO:0005925; GO:0006936; GO:0007160; GO:0008092; GO:0008286; GO:0015758; GO:0016363; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q9VCA8 CHOYP_LOC100637968.3.12 m.14999 sp ANKHM_DROME 31.278 454 263 16 11 450 619 1037 8.07E-43 165 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; O43301 CHOYP_HS12B.9.14 m.56388 sp HS12A_HUMAN 29.36 453 254 14 811 1203 9 455 8.08E-42 167 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P08953 CHOYP_TOLL-1.1.1 m.37581 sp TOLL_DROME 22.118 642 409 27 111 698 378 982 8.08E-16 85.5 TOLL_DROME reviewed Protein toll Tl CG5490 Drosophila melanogaster (Fruit fly) 1097 antifungal humoral response [GO:0019732]; antimicrobial humoral response [GO:0019730]; cell adhesion [GO:0007155]; defense response [GO:0006952]; defense response to fungus [GO:0050832]; defense response to Gram-positive bacterium [GO:0050830]; defense response to oomycetes [GO:0002229]; dorsal/ventral axis specification [GO:0009950]; embryonic pattern specification [GO:0009880]; heart development [GO:0007507]; hemocyte proliferation [GO:0035172]; hemopoiesis [GO:0030097]; immune response [GO:0006955]; innate immune response [GO:0045087]; larval somatic muscle development [GO:0007526]; mitotic cytokinesis [GO:0000281]; positive regulation of antibacterial peptide biosynthetic process [GO:0006963]; positive regulation of antifungal peptide biosynthetic process [GO:0006967]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of embryonic pattern specification [GO:1902875]; regulation of hemocyte differentiation [GO:0045610]; regulation of melanization defense response [GO:0035007]; response to bacterium [GO:0009617]; response to fungus [GO:0009620]; synapse assembly [GO:0007416]; synaptic target inhibition [GO:0016201]; Toll signaling pathway [GO:0008063]; zygotic specification of dorsal/ventral axis [GO:0007352] GO:0000281; GO:0002229; GO:0004888; GO:0005737; GO:0005769; GO:0005886; GO:0006952; GO:0006955; GO:0006963; GO:0006967; GO:0007155; GO:0007352; GO:0007416; GO:0007507; GO:0007526; GO:0008063; GO:0009617; GO:0009620; GO:0009880; GO:0009897; GO:0009950; GO:0009986; GO:0016021; GO:0016201; GO:0019730; GO:0019732; GO:0019955; GO:0030097; GO:0032154; GO:0035007; GO:0035172; GO:0042802; GO:0043234; GO:0045087; GO:0045610; GO:0045944; GO:0050830; GO:0050832; GO:0070976; GO:1902875 0 0 0 PF00560;PF13306;PF13855;PF01462;PF01582; P15870 CHOYP_LOC100635715.6.9 m.16736 sp H1D_STRPU 64.474 76 24 1 24 99 31 103 8.08E-26 101 H1D_STRPU reviewed Histone H1-delta 0 Strongylocentrotus purpuratus (Purple sea urchin) 185 nucleosome assembly [GO:0006334] GO:0000786; GO:0003677; GO:0005634; GO:0006334 0 0 0 PF00538; P17141 CHOYP_BRAFLDRAFT_63860.1.1 m.19386 sp ZFP37_MOUSE 32.418 182 109 8 703 876 246 421 8.08E-14 79 ZFP37_MOUSE reviewed Zinc finger protein 37 (Zfp-37) (Male germ cell-specific zinc finger protein) Zfp37 Zfp-37 Mus musculus (Mouse) 594 "germ cell development [GO:0007281]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0007281; GO:0007283; GO:0008270 0 0 cd07765; PF01352;PF00096;PF13912; P19945 CHOYP_BRAFLDRAFT_127105.1.1 m.21926 sp RLA0_RAT 75.962 104 25 0 1 104 1 104 8.08E-52 167 RLA0_RAT reviewed 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) Rplp0 Arbp Rattus norvegicus (Rat) 317 cellular response to cAMP [GO:0071320]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to Thyroid stimulating hormone [GO:1904401]; cytoplasmic translation [GO:0002181]; lactation [GO:0007595]; response to selenium ion [GO:0010269]; ribosome biogenesis [GO:0042254] GO:0002181; GO:0003735; GO:0005634; GO:0005737; GO:0007595; GO:0010269; GO:0016020; GO:0022625; GO:0030529; GO:0030687; GO:0042254; GO:0042277; GO:0070180; GO:0071320; GO:1904401; GO:1904628 0 0 0 PF00466; P34416 CHOYP_LOC663855.5.5 m.51311 sp LASP1_CAEEL 41.257 366 156 7 1 351 1 322 8.08E-82 255 LASP1_CAEEL reviewed LIM and SH3 domain protein F42H10.3 F42H10.3 Caenorhabditis elegans 335 0 GO:0008270; GO:0030054; GO:0055120 0 0 0 PF00412;PF00880;PF00018; P42942 CHOYP_BRAFLDRAFT_85626.1.1 m.19394 sp YG4I_YEAST 34.321 405 238 9 152 538 6 400 8.08E-69 230 YG4I_YEAST reviewed Uncharacterized GTP-binding protein YGR210C YGR210C G7748 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 411 0 GO:0005525 0 0 0 PF01926;PF08438; Q14202 CHOYP_BRAFLDRAFT_106251.6.6 m.52605 sp ZMYM3_HUMAN 38.849 139 75 3 136 272 1102 1232 8.08E-14 77 ZMYM3_HUMAN reviewed Zinc finger MYM-type protein 3 (Zinc finger protein 261) ZMYM3 DXS6673E KIAA0385 ZNF261 Homo sapiens (Human) 1370 cytoskeleton organization [GO:0007010]; multicellular organism development [GO:0007275]; regulation of cell morphogenesis [GO:0022604] GO:0000981; GO:0003677; GO:0005654; GO:0005737; GO:0007010; GO:0007275; GO:0008270; GO:0022604 0 0 0 PF12012;PF06467; Q2KIR0 CHOYP_NEMVEDRAFT_V1G208725.1.1 m.36498 sp CD045_BOVIN 36.449 107 65 2 32 135 17 123 8.08E-12 64.3 CD045_BOVIN reviewed Uncharacterized protein C4orf45 homolog 0 Bos taurus (Bovine) 197 0 0 0 0 0 PF15123; Q2T9Q1 CHOYP_BRAFLDRAFT_121942.2.2 m.54709 sp TBC20_BOVIN 54.576 295 134 0 1 295 32 326 8.08E-109 326 TBC20_BOVIN reviewed TBC1 domain family member 20 TBC1D20 Bos taurus (Bovine) 403 acrosome assembly [GO:0001675]; cargo loading into COPII-coated vesicle [GO:0090110]; Golgi organization [GO:0007030]; lens fiber cell morphogenesis [GO:0070309]; lipid particle organization [GO:0034389]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; seminiferous tubule development [GO:0072520]; virion assembly [GO:0019068] GO:0001675; GO:0005096; GO:0005789; GO:0007030; GO:0019068; GO:0030173; GO:0031965; GO:0034389; GO:0044829; GO:0046726; GO:0070309; GO:0072520; GO:0090110; GO:1902953 0 0 0 PF00566; Q3UHA3 CHOYP_BRAFLDRAFT_78622.2.3 m.8255 sp SPTCS_MOUSE 44.444 63 33 1 280 342 475 535 8.08E-10 63.9 SPTCS_MOUSE reviewed Spatacsin (Spastic paraplegia 11 protein homolog) Spg11 Kiaa1840 Mus musculus (Mouse) 2430 axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; axonogenesis [GO:0007409]; chemical synaptic transmission [GO:0007268]; regulation of synaptic plasticity [GO:0048167]; synaptic vesicle transport [GO:0048489] GO:0005730; GO:0005737; GO:0005765; GO:0005829; GO:0005886; GO:0007268; GO:0007409; GO:0008088; GO:0030054; GO:0030424; GO:0030425; GO:0031410; GO:0045202; GO:0048167; GO:0048489; GO:0048675; GO:0070062 0 0 0 PF14649; Q6PDJ1 CHOYP_LOC100183158.2.2 m.44742 sp CAHD1_MOUSE 31.311 511 308 18 3 488 348 840 8.08E-50 186 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q964E0 CHOYP_ACTC.6.6 m.66963 sp ACTC_BIOTE 80.795 151 16 1 4 154 239 376 8.08E-82 248 ACTC_BIOTE reviewed "Actin, cytoplasmic" 0 Biomphalaria tenagophila (Bloodfluke planorb) (Freshwater snail) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9CPV3 CHOYP_MRPL42.1.1 m.61762 sp RM42_MOUSE 28 150 94 6 11 154 1 142 8.08E-11 60.1 RM42_MOUSE reviewed "39S ribosomal protein L42, mitochondrial (L42mt) (MRP-L42) (28S ribosomal protein S32, mitochondrial) (MRP-S32) (S32mt) (39S ribosomal protein L31, mitochondrial) (L31mt) (MRP-L31)" Mrpl42 D10Ertd322e Mrps32 Mus musculus (Mouse) 142 0 GO:0005739; GO:0005763; GO:0005886; GO:0044822 0 0 0 PF10210; P20825 CHOYP_CRE_29046.1.1 m.25490 sp POL2_DROME 36.496 411 236 5 158 567 241 627 8.09E-74 257 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P21328 CHOYP_LOC100561123.27.28 m.61734 sp RTJK_DROME 26.885 305 208 5 9 306 469 765 8.09E-27 116 RTJK_DROME reviewed RNA-directed DNA polymerase from mobile element jockey (EC 2.7.7.49) (Reverse transcriptase) pol Drosophila melanogaster (Fruit fly) 916 0 GO:0003964 0 0 0 PF14529;PF00078; Q24307 CHOYP_BIR.1.1 m.33814 sp DIAP2_DROME 25.132 569 291 17 324 836 6 495 8.09E-35 142 DIAP2_DROME reviewed Death-associated inhibitor of apoptosis 2 (EC 6.3.2.-) (Apoptosis 2 inhibitor) (IAP homolog A) (IAP-like protein) (ILP) (dILP) (Inhibitor of apoptosis 2) Diap2 DIHA Iap2 Ilp CG8293 Drosophila melanogaster (Fruit fly) 498 "defense response to Gram-negative bacterium [GO:0050829]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; innate immune response [GO:0045087]; mitotic spindle assembly [GO:0090307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; peptidoglycan recognition protein signaling pathway [GO:0061057]; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [GO:0006964]; positive regulation of protein import into nucleus, translocation [GO:0033160]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281]; regulation of signal transduction [GO:0009966]; sensory organ development [GO:0007423]" GO:0005634; GO:0005876; GO:0006964; GO:0007423; GO:0008270; GO:0009966; GO:0016567; GO:0016874; GO:0031625; GO:0033160; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0043281; GO:0045087; GO:0048471; GO:0050829; GO:0061057; GO:0061630; GO:0070534; GO:0070936; GO:0089720; GO:0090307; GO:1990001 0 0 0 PF00653; Q4PMB3 CHOYP_RS4.9.11 m.59261 sp RS4_IXOSC 69.271 192 58 1 14 205 71 261 8.09E-94 277 RS4_IXOSC reviewed 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) 262 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q6AZ60 CHOYP_MEGF10.3.12 m.22452 sp EGFL7_RAT 35 100 55 3 52 146 85 179 8.09E-08 55.8 EGFL7_RAT reviewed Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) Egfl7 Cbl20 Megf7 Rattus norvegicus (Rat) 279 angiogenesis [GO:0001525]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of endothelial cell proliferation [GO:0001938]; vasculogenesis [GO:0001570] GO:0001525; GO:0001568; GO:0001570; GO:0001938; GO:0005509; GO:0005576; GO:0005615; GO:0007155; GO:0031012; GO:0045746 0 0 0 PF07974;PF07645;PF07546; Q6J6I8 CHOYP_LOC590989.3.3 m.32047 sp BRCA1_GORGO 31.148 122 79 3 3 124 1680 1796 8.09E-12 73.6 BRCA1_GORGO reviewed Breast cancer type 1 susceptibility protein homolog (EC 6.3.2.-) BRCA1 Gorilla gorilla gorilla (Western lowland gorilla) 1863 "cell cycle [GO:0007049]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; fatty acid biosynthetic process [GO:0006633]; negative regulation of fatty acid biosynthetic process [GO:0045717]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autoubiquitination [GO:0051865]; protein K6-linked ubiquitination [GO:0085020]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004842; GO:0005634; GO:0005694; GO:0005737; GO:0006281; GO:0006310; GO:0006351; GO:0006633; GO:0007049; GO:0008270; GO:0016874; GO:0031436; GO:0045717; GO:0045893; GO:0051865; GO:0085020 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00533;PF12820;PF00097; Q96RW7 CHOYP_BM1_12515.5.7 m.40490 sp HMCN1_HUMAN 24 400 262 16 242 631 4019 4386 8.09E-06 54.3 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9BVM4 CHOYP_A2LDB.1.1 m.29880 sp GGACT_HUMAN 41.104 163 77 3 1 159 1 148 8.09E-34 119 GGACT_HUMAN reviewed Gamma-glutamylaminecyclotransferase (GGACT) (EC 2.3.2.4) (AIG2-like domain-containing protein 1) (Gamma-glutamylamine cyclotransferase) GGACT A2LD1 Homo sapiens (Human) 153 cellular modified amino acid catabolic process [GO:0042219] GO:0003839; GO:0042219; GO:0070062 0 0 cd06661; PF06094; Q9ULJ7 CHOYP_Y220.5.6 m.54136 sp ANR50_HUMAN 38.235 204 126 0 197 400 704 907 8.09E-35 140 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9UQ07 CHOYP_LOC100377851.1.2 m.27170 sp MOK_HUMAN 69.863 292 88 0 73 364 4 295 8.09E-159 461 MOK_HUMAN reviewed MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1) MOK RAGE RAGE1 Homo sapiens (Human) 419 protein phosphorylation [GO:0006468]; signal transduction [GO:0007165] GO:0004672; GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005929; GO:0006468; GO:0007165; GO:0097546 0 0 0 PF00069; A4IF63 CHOYP_BRAFLDRAFT_205965.39.43 m.64643 sp TRIM2_BOVIN 26.712 146 93 4 110 252 609 743 8.10E-08 56.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A8C750 CHOYP_THADA.1.2 m.12972 sp THADA_CANLF 31.887 1383 748 36 6 1286 590 1880 8.10E-176 576 THADA_CANLF reviewed Thyroid adenoma-associated protein homolog THADA Canis lupus familiaris (Dog) (Canis familiaris) 1948 0 0 0 0 0 PF10350; O35186 CHOYP_LOC763308.1.3 m.13100 sp CATK_RAT 46.789 327 168 3 44 366 3 327 8.10E-108 322 CATK_RAT reviewed Cathepsin K (EC 3.4.22.38) Ctsk Rattus norvegicus (Rat) 329 bone resorption [GO:0045453]; collagen catabolic process [GO:0030574]; intramembranous ossification [GO:0001957]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteolysis [GO:0006508]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of mitophagy [GO:1903146] GO:0001957; GO:0004197; GO:0005615; GO:0005737; GO:0005764; GO:0006508; GO:0008234; GO:0030574; GO:0043394; GO:0045453; GO:0051603; GO:1903146; GO:1903955 0 0 0 PF08246;PF00112; P05450 CHOYP_contig_055613 m.66233 sp YAT7_RHOBL 33.333 66 44 0 148 213 39 104 8.10E-08 52.4 YAT7_RHOBL reviewed ATP synthase subunits region ORF 7 0 Rhodobacter blasticus (Rhodopseudomonas blastica) 115 cell adhesion [GO:0007155] GO:0007155; GO:0030246 0 0 0 PF09458; P22727 CHOYP_BRAFLDRAFT_57222.1.1 m.29887 sp WNT6_MOUSE 52.722 349 143 2 19 347 18 364 8.10E-136 393 WNT6_MOUSE reviewed Protein Wnt-6 Wnt6 Wnt-6 Mus musculus (Mouse) 364 "axis specification [GO:0009798]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell-cell signaling [GO:0007267]; cell fate commitment [GO:0045165]; epithelial-mesenchymal cell signaling [GO:0060684]; nephron tubule development [GO:0072080]; nephron tubule formation [GO:0072079]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; organ morphogenesis [GO:0009887]; positive regulation of gene expression [GO:0010628]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription, DNA-templated [GO:0045893]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]" GO:0001658; GO:0005102; GO:0005109; GO:0005578; GO:0005615; GO:0005788; GO:0007165; GO:0007267; GO:0009798; GO:0009887; GO:0009986; GO:0010628; GO:0016055; GO:0030182; GO:0042475; GO:0045165; GO:0045893; GO:0060684; GO:0070172; GO:0072079; GO:0072080 0 0 0 PF00110; P81559 CHOYP_ER.1.2 m.14189 sp ESR1_XENLA 51.012 247 111 5 128 365 177 422 8.10E-81 260 ESR1_XENLA reviewed Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) esr1 esr nr3a1 Xenopus laevis (African clawed frog) 586 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005496; GO:0005634; GO:0006351; GO:0008270; GO:0030284; GO:0043565 0 0 0 PF12743;PF00104;PF02159;PF00105; Q0IIF9 CHOYP_CP2DR.1.1 m.26018 sp CP2U1_BOVIN 43.434 99 54 2 1 98 345 442 8.10E-19 82.8 CP2U1_BOVIN reviewed Cytochrome P450 2U1 (EC 1.14.14.1) CYP2U1 Bos taurus (Bovine) 543 0 GO:0005506; GO:0005789; GO:0008395; GO:0016021; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; Q12912 CHOYP_LOC100379008.1.4 m.17067 sp LRMP_HUMAN 44.199 181 93 4 1222 1400 207 381 8.10E-33 139 LRMP_HUMAN reviewed Lymphoid-restricted membrane protein (Protein Jaw1) [Cleaved into: Processed lymphoid-restricted membrane protein] LRMP JAW1 Homo sapiens (Human) 555 immune system process [GO:0002376]; single fertilization [GO:0007338]; vesicle fusion [GO:0006906]; vesicle targeting [GO:0006903] GO:0000922; GO:0002376; GO:0005635; GO:0005694; GO:0005789; GO:0005815; GO:0005887; GO:0006903; GO:0006906; GO:0007338; GO:0016020; GO:0016021 0 0 0 PF05781; Q5R5W9 CHOYP_LOC101381408.1.1 m.10131 sp CE022_PONAB 54.305 151 69 0 11 161 11 161 8.10E-55 193 CE022_PONAB reviewed UPF0489 protein C5orf22 homolog 0 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 442 0 0 0 0 0 PF12640; Q8KWM1 CHOYP_CBG22657.2.2 m.28802 sp SDRI_STASA 32.484 157 94 1 223 367 84 240 8.10E-06 52.8 SDRI_STASA reviewed Serine-aspartate repeat-containing protein I sdrI Staphylococcus saprophyticus 1893 cell adhesion [GO:0007155] GO:0005576; GO:0005618; GO:0007155; GO:0016020 0 0 0 PF00746;PF10425;PF04650; Q96A56 CHOYP_BRAFLDRAFT_117676.1.1 m.13578 sp T53I1_HUMAN 29.518 166 98 8 24 181 85 239 8.10E-07 50.8 T53I1_HUMAN reviewed Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1) TP53INP1 P53DINP1 SIP Homo sapiens (Human) 240 "apoptotic process [GO:0006915]; autophagic cell death [GO:0048102]; autophagosome assembly [GO:0000045]; cell cycle arrest [GO:0007050]; cellular response to ethanol [GO:0071361]; cellular response to hydroperoxide [GO:0071447]; cellular response to methyl methanesulfonate [GO:0072703]; cellular response to UV [GO:0034644]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of autophagy [GO:0010508]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of apoptotic process [GO:0042981]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to heat [GO:0009408]; response to stress [GO:0006950]; transcription, DNA-templated [GO:0006351]" GO:0000045; GO:0005634; GO:0005654; GO:0005737; GO:0005776; GO:0005829; GO:0006351; GO:0006915; GO:0006950; GO:0007050; GO:0008285; GO:0009408; GO:0010508; GO:0016209; GO:0016605; GO:0030336; GO:0031410; GO:0034644; GO:0042981; GO:0045893; GO:0048102; GO:0071361; GO:0071447; GO:0072703; GO:1901796; GO:2001235 0 0 0 PF14839; Q9BZE2 CHOYP_PUS3.1.1 m.9880 sp PUS3_HUMAN 47.775 427 202 6 549 958 14 436 8.10E-139 427 PUS3_HUMAN reviewed tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3) PUS3 FKSG32 Homo sapiens (Human) 481 tRNA pseudouridine synthesis [GO:0031119] GO:0003723; GO:0005634; GO:0009982; GO:0031119 0 0 0 PF01416; Q9ESN6 CHOYP_TRIM2.21.59 m.32903 sp TRIM2_MOUSE 26.267 217 114 8 199 370 492 707 8.10E-08 57.8 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A5D8N2 CHOYP_DPCD.1.1 m.29837 sp DPCD_XENLA 60.406 197 75 2 4 198 5 200 8.11E-88 259 DPCD_XENLA reviewed Protein DPCD dpcd Xenopus laevis (African clawed frog) 203 0 0 0 0 0 0 P54357 CHOYP_LOC100881900.1.3 m.1852 sp MLC2_DROME 65.306 147 51 0 28 174 1 147 8.11E-69 208 MLC2_DROME reviewed Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain) Mlc-c CG3201 Drosophila melanogaster (Fruit fly) 147 actin filament-based movement [GO:0030048] GO:0005509; GO:0016459; GO:0016460; GO:0017022; GO:0030048; GO:0031475; GO:0031476; GO:0031477; GO:0032036 0 0 0 PF13405;PF13499; Q24K15 CHOYP_LOC100693359.1.1 m.2738 sp ANGP4_BOVIN 44.076 211 115 3 97 305 285 494 8.11E-58 196 ANGP4_BOVIN reviewed Angiopoietin-4 (ANG-4) ANGPT4 Bos taurus (Bovine) 498 angiogenesis [GO:0001525] GO:0001525; GO:0005576 0 0 0 PF00147; Q29486 CHOYP_PPBT.1.4 m.5115 sp PPBT_FELCA 54.209 487 204 8 47 525 28 503 8.11E-177 511 PPBT_FELCA reviewed "Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase liver/bone/kidney isozyme)" ALPL Felis catus (Cat) (Felis silvestris catus) 524 dephosphorylation [GO:0016311] GO:0004035; GO:0016311; GO:0046658; GO:0046872 0 0 0 PF00245; Q502M6 CHOYP_TVAG_123950.24.31 m.54150 sp ANR29_DANRE 43.262 141 80 0 1 141 67 207 8.11E-34 122 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5ZIN2 CHOYP_LOC100374985.1.1 m.12879 sp SEN2_CHICK 46.86 207 103 3 339 545 256 455 8.11E-58 202 SEN2_CHICK reviewed tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) TSEN2 RCJMB04_24m3 Gallus gallus (Chicken) 461 mRNA processing [GO:0006397]; tRNA-type intron splice site recognition and cleavage [GO:0000379] GO:0000213; GO:0000214; GO:0000379; GO:0003676; GO:0006397; GO:0016829 0 0 0 PF01974;PF02778; Q8WVZ9 CHOYP_BACH1.15.17 m.51790 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 8.11E-09 62.4 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q9NPI0 CHOYP_BRAFLDRAFT_277366.1.1 m.26659 sp TM138_HUMAN 59.859 142 56 1 20 161 21 161 8.11E-56 175 TM138_HUMAN reviewed Transmembrane protein 138 TMEM138 HSPC196 HSPC198 Homo sapiens (Human) 162 cilium assembly [GO:0042384] GO:0005774; GO:0005929; GO:0016021; GO:0042384 0 0 0 PF14935; Q9VEU1 CHOYP_CAD99C-LIKE.1.1 m.26395 sp CAD89_DROME 29.386 228 135 10 113 326 144 359 8.11E-11 68.9 CAD89_DROME reviewed Cadherin-89D Cad89D CG14900 Drosophila melanogaster (Fruit fly) 2240 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005887; GO:0007156; GO:0016339; GO:0044331 0 0 0 PF00028; Q9Z0W1 CHOYP_NGFR.1.1 m.43909 sp TNR16_MOUSE 28.354 395 224 8 22 367 23 407 8.11E-37 141 TNR16_MOUSE reviewed Tumor necrosis factor receptor superfamily member 16 (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (CD antigen CD271) Ngfr Tnfrsf16 Mus musculus (Mouse) 417 apoptotic process [GO:0006915]; axon guidance [GO:0007411]; central nervous system development [GO:0007417]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; detection of temperature stimulus [GO:0016048]; glucose homeostasis [GO:0042593]; hair follicle morphogenesis [GO:0031069]; immune response [GO:0006955]; inflammatory response [GO:0006954]; intracellular protein transport [GO:0006886]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of hair follicle development [GO:0051799]; negative regulation of neuron projection development [GO:0010977]; nerve development [GO:0021675]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of odontogenesis of dentin-containing tooth [GO:0042488]; regulation of gene expression [GO:0010468]; regulation of glucose import in response to insulin stimulus [GO:2001273]; response to lipopolysaccharide [GO:0032496]; skin development [GO:0043588] GO:0005031; GO:0005035; GO:0005634; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006886; GO:0006915; GO:0006954; GO:0006955; GO:0007411; GO:0007417; GO:0007623; GO:0009986; GO:0010468; GO:0010977; GO:0014069; GO:0016048; GO:0017137; GO:0021675; GO:0031069; GO:0031625; GO:0032496; GO:0032922; GO:0040037; GO:0042488; GO:0042593; GO:0043005; GO:0043065; GO:0043410; GO:0043588; GO:0048146; GO:0048406; GO:0051799; GO:2001235; GO:2001273 0 0 0 PF00531;PF00020; A4IF63 CHOYP_BRAFLDRAFT_69765.14.23 m.52675 sp TRIM2_BOVIN 26.056 142 100 3 30 167 602 742 8.12E-08 55.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D8VNS7 CHOYP_LOC100632478.2.2 m.61868 sp FCNV1_CERRY 48.148 189 96 2 68 256 128 314 8.12E-53 178 FCNV1_CERRY reviewed Ryncolin-1 0 Cerberus rynchops (Dog-faced water snake) 345 0 GO:0005576 0 0 0 PF01391;PF00147; O01761 CHOYP_NCAM1.1.1 m.14783 sp UNC89_CAEEL 25.205 365 239 17 235 585 4521 4865 8.12E-09 64.3 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; P18503 CHOYP_BRAFLDRAFT_76550.2.21 m.4502 sp CAS4_EPHMU 31.746 126 72 3 25 150 202 313 8.12E-07 52 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P43935 CHOYP_LOC734029.2.2 m.34544 sp Y077_HAEIN 35.789 190 118 2 270 459 84 269 8.12E-29 118 Y077_HAEIN reviewed Uncharacterized protein HI_0077 HI_0077 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 288 0 0 0 0 0 PF04305; P70227 CHOYP_LOC100375107.3.4 m.20175 sp ITPR3_MOUSE 23.218 1529 890 48 1 1347 4 1430 8.12E-68 259 ITPR3_MOUSE reviewed "Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)" Itpr3 Mus musculus (Mouse) 2670 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cellular response to cAMP [GO:0071320]; G-protein coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917] GO:0000822; GO:0005220; GO:0005509; GO:0005634; GO:0005640; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005829; GO:0005886; GO:0005887; GO:0006816; GO:0007186; GO:0007613; GO:0015278; GO:0016020; GO:0030425; GO:0035091; GO:0043025; GO:0043209; GO:0043235; GO:0043533; GO:0048471; GO:0050913; GO:0050916; GO:0050917; GO:0051260; GO:0051291; GO:0051592; GO:0060291; GO:0060402; GO:0070679; GO:0071320 0 0 0 PF08709;PF00520;PF02815;PF08454;PF01365; P86856 CHOYP_MANL.2.9 m.16934 sp MANL_MYTCA 50.314 159 72 4 53 207 1 156 8.12E-41 151 MANL_MYTCA reviewed Nacrein-like protein (Fragment) 0 Mytilus californianus (California mussel) 321 0 GO:0005576 0 0 0 PF00194; Q07837 CHOYP_LOC100368193.1.1 m.36318 sp SLC31_HUMAN 31.788 151 93 8 107 251 504 650 8.12E-10 62 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q16629 CHOYP_LOC100371721.1.1 m.23143 sp SRSF7_HUMAN 50 108 48 1 35 136 12 119 8.12E-27 109 SRSF7_HUMAN reviewed "Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)" SRSF7 SFRS7 Homo sapiens (Human) 238 "mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]" GO:0000166; GO:0000398; GO:0005634; GO:0005654; GO:0005737; GO:0006369; GO:0006397; GO:0006405; GO:0006406; GO:0008270; GO:0008380; GO:0031124; GO:0044822; GO:0048025; GO:0070062 0 0 0 PF00076; Q8IYJ2 CHOYP_BRAFLDRAFT_129914.2.3 m.58991 sp CJ067_HUMAN 26.773 437 280 8 50 466 70 486 8.12E-30 127 CJ067_HUMAN reviewed "Uncharacterized protein C10orf67, mitochondrial" C10orf67 LINC01552 Homo sapiens (Human) 551 0 GO:0005739 0 0 0 PF15821;PF15852; Q9C0D2 CHOYP_LOC763378.1.1 m.7889 sp CE295_HUMAN 37.53 421 226 10 89 494 10 408 8.12E-56 219 CE295_HUMAN reviewed Centrosomal protein of 295 kDa CEP295 KIAA1731 Homo sapiens (Human) 2601 positive regulation of organelle assembly [GO:1902117] GO:0005737; GO:0005813; GO:0005814; GO:0005856; GO:1902117 0 0 0 PF15309; Q9CQV4 CHOYP_F134C.1.1 m.51074 sp F134C_MOUSE 34.839 310 191 6 11 314 32 336 8.12E-52 184 F134C_MOUSE reviewed Protein FAM134C Fam134c Mus musculus (Mouse) 466 positive regulation of neuron projection development [GO:0010976] GO:0010976; GO:0016021 0 0 0 0 Q9MYM7 CHOYP_B3GT1.1.2 m.25021 sp B3GT1_PONPY 33.758 314 198 6 7 314 9 318 8.12E-55 184 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9W6B4 CHOYP_TIMP3.6.9 m.43446 sp TIMP3_SCYTO 34.058 138 85 5 13 146 18 153 8.12E-17 78.2 TIMP3_SCYTO reviewed Metalloproteinase inhibitor 3 (Tissue inhibitor of metalloproteinases 3) (TIMP-3) TIMP3 Scyliorhinus torazame (Cloudy catshark) 214 0 GO:0005578; GO:0008191; GO:0046872 0 0 0 PF00965; A8MTY0 CHOYP_ZNF43.1.1 m.6773 sp ZN724_HUMAN 42.4 250 143 1 79 327 366 615 8.13E-57 198 ZN724_HUMAN reviewed Putative zinc finger protein 724 ZNF724P Homo sapiens (Human) 619 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; O75382 CHOYP_BRAFLDRAFT_205965.22.43 m.42084 sp TRIM3_HUMAN 26.016 123 86 3 54 172 622 743 8.13E-06 52 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0CT43 CHOYP_contig_021882 m.25114 sp TF28_SCHPO 31.132 106 67 4 97 196 902 1007 8.13E-06 49.3 TF28_SCHPO reviewed Transposon Tf2-8 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-8 Tf2-9 SPAC13D1.02c SPAC19D5.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P23708 CHOYP_NFYA.2.2 m.18948 sp NFYA_MOUSE 69.231 78 21 2 186 261 246 322 8.13E-28 115 NFYA_MOUSE reviewed Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) Nfya Mus musculus (Mouse) 346 "positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription, DNA-templated [GO:0006355]; rhythmic process [GO:0048511]" GO:0000978; GO:0001046; GO:0001077; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0006355; GO:0016602; GO:0032993; GO:0045893; GO:0045944; GO:0048511; GO:2000036; GO:2000648 0 0 0 PF02045; Q39575 CHOYP_LOC577805.2.4 m.20442 sp DYHG_CHLRE 27.049 610 365 8 720 1329 472 1001 8.13E-67 253 DYHG_CHLRE reviewed "Dynein gamma chain, flagellar outer arm" ODA2 ODA-2 Chlamydomonas reinhardtii (Chlamydomonas smithii) 4485 cilium movement involved in cell motility [GO:0060294]; outer dynein arm assembly [GO:0036158] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0016887; GO:0030286; GO:0031514; GO:0036158; GO:0060294 0 0 0 PF07728;PF12780;PF08385;PF08393;PF03028;PF12777; Q56K03 CHOYP_LOC100215276.1.1 m.22187 sp RL27A_BOVIN 73.649 148 39 0 4 151 1 148 8.13E-77 228 RL27A_BOVIN reviewed 60S ribosomal protein L27a RPL27A Bos taurus (Bovine) 148 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00828; Q5ND28 CHOYP_BM1_57400.3.7 m.35268 sp SREC_MOUSE 37.158 183 106 7 181 363 213 386 8.13E-22 103 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q8BHR2 CHOYP_LOC660510.1.1 m.56258 sp ENOX1_MOUSE 39.906 213 103 5 37 227 428 637 8.13E-31 122 ENOX1_MOUSE reviewed Ecto-NOX disulfide-thiol exchanger 1 (Constitutive Ecto-NOX) (cNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)] Enox1 Mus musculus (Mouse) 643 rhythmic process [GO:0048511] GO:0000166; GO:0003676; GO:0005615; GO:0005886; GO:0016491; GO:0048511 0 0 0 PF00076; Q8C0R7 CHOYP_ZMY15.1.1 m.46851 sp ZMY15_MOUSE 27.292 480 290 13 38 471 217 683 8.13E-48 178 ZMY15_MOUSE reviewed Zinc finger MYND domain-containing protein 15 Zmynd15 Mus musculus (Mouse) 736 "negative regulation of transcription, DNA-templated [GO:0045892]; spermatid development [GO:0007286]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0007286; GO:0042826; GO:0045892; GO:0046872 0 0 0 PF01753; Q8NEN9 CHOYP_LOC100214660.1.1 m.46011 sp PDZD8_HUMAN 36.203 453 230 10 2 403 3 447 8.13E-77 266 PDZD8_HUMAN reviewed PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104) PDZD8 PDZK8 Homo sapiens (Human) 1154 cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; regulation of cell morphogenesis [GO:0022604]; viral process [GO:0016032] GO:0005622; GO:0007010; GO:0016020; GO:0016032; GO:0022604; GO:0035556; GO:0046872 0 0 0 PF00130;PF00595; Q8R314 CHOYP_R35A.1.1 m.5769 sp S35F5_MOUSE 50 118 47 4 6 115 62 175 8.13E-29 112 S35F5_MOUSE reviewed Solute carrier family 35 member F5 Slc35f5 Mus musculus (Mouse) 524 transport [GO:0006810] GO:0006810; GO:0016021 0 0 0 PF00892; Q92626 CHOYP_UNC89.10.19 m.36699 sp PXDN_HUMAN 22.532 395 251 21 237 615 277 632 8.13E-07 57.4 PXDN_HUMAN reviewed Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein) PXDN KIAA0230 MG50 PRG2 VPO VPO1 Homo sapiens (Human) 1479 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005152; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006955; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q9I8C7 CHOYP_SMP_037960.1.1 m.41589 sp ACH10_CHICK 34.818 494 268 12 5 496 10 451 8.13E-93 292 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9UKI9 CHOYP_PO2F1.1.1 m.11428 sp PO2F3_HUMAN 60.324 247 70 8 289 530 173 396 8.13E-84 271 PO2F3_HUMAN reviewed "POU domain, class 2, transcription factor 3 (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (Transcription factor PLA-1) (Transcription factor Skn-1)" POU2F3 OTF11 PLA1 Homo sapiens (Human) 436 epidermis development [GO:0008544]; negative regulation by host of viral transcription [GO:0043922]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000978; GO:0001077; GO:0005634; GO:0005654; GO:0005737; GO:0006357; GO:0008544; GO:0043565; GO:0043922; GO:0045944 0 0 0 PF00046;PF00157; Q9YGP1 CHOYP_BRAFLDRAFT_117284.2.7 m.14332 sp LECG_TRIST 33.065 124 74 5 44 159 33 155 8.13E-12 69.3 LECG_TRIST reviewed C-type lectin TsL (Galactose-binding lectin) (CTL) 0 Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri) 158 0 GO:0005576; GO:0030246; GO:0046872 0 0 0 PF00059; A6BM72 CHOYP_MEGF11.6.11 m.50648 sp MEG11_HUMAN 34.752 282 160 12 182 458 427 689 8.14E-29 125 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; D2GXS7 CHOYP_BRAFLDRAFT_205965.11.43 m.23937 sp TRIM2_AILME 23.684 152 115 1 127 278 593 743 8.14E-08 57 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P23683 CHOYP_BRAFLDRAFT_116902.1.1 m.11034 sp EVX1_MOUSE 65.116 129 34 6 101 223 183 306 8.14E-43 155 EVX1_MOUSE reviewed Homeobox even-skipped homolog protein 1 (EVX-1) Evx1 Mus musculus (Mouse) 416 embryo development ending in birth or egg hatching [GO:0009792]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification [GO:0021913] GO:0005654; GO:0009792; GO:0016235; GO:0021913; GO:0031965; GO:0043565; GO:0045944 0 0 0 PF00046; P24367 CHOYP_LOC100304997.1.1 m.14296 sp PPIB_CHICK 65.441 136 43 2 2 137 59 190 8.14E-57 179 PPIB_CHICK reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207 chaperone-mediated protein folding [GO:0061077]; protein peptidyl-prolyl isomerization [GO:0000413] GO:0000413; GO:0003755; GO:0005788; GO:0032403; GO:0032991; GO:0042277; GO:0042470; GO:0061077 0 0 0 PF00160; P48605 CHOYP_LOC100372926.1.3 m.29882 sp TCPG_DROME 73.704 270 71 0 1 270 1 270 8.14E-147 425 TCPG_DROME reviewed T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) Cctgamma CCT-3 Cctg CG8977 Drosophila melanogaster (Fruit fly) 544 "mitotic spindle assembly [GO:0090307]; mitotic spindle organization [GO:0007052]; protein folding [GO:0006457]; terminal branching, open tracheal system [GO:0007430]; trachea morphogenesis [GO:0060439]" GO:0005524; GO:0005832; GO:0005875; GO:0006457; GO:0007052; GO:0007430; GO:0042623; GO:0060439; GO:0090307 0 0 cd03337; PF00118; Q5G267 CHOYP_DMBT1.32.34 m.59392 sp NETR_MACMU 38.991 436 245 8 22 443 170 598 8.14E-90 294 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q6DRL4 CHOYP_BRAFLDRAFT_121706.1.1 m.8132 sp TICRR_DANRE 28.266 421 249 14 650 1045 625 1017 8.14E-19 97.4 TICRR_DANRE reviewed "Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)" ticrr Danio rerio (Zebrafish) (Brachydanio rerio) 1824 cell cycle checkpoint [GO:0000075]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; formation of translation preinitiation complex [GO:0001731]; mitotic cell cycle checkpoint [GO:0007093]; mitotic DNA replication checkpoint [GO:0033314]; mitotic G2 DNA damage checkpoint [GO:0007095]; regulation of DNA-dependent DNA replication initiation [GO:0030174]; response to ionizing radiation [GO:0010212] GO:0000075; GO:0001731; GO:0003682; GO:0005634; GO:0006260; GO:0006281; GO:0007093; GO:0007095; GO:0010212; GO:0030174; GO:0033314 0 0 0 PF15292; Q6PFY8 CHOYP_BRAFLDRAFT_85511.3.23 m.14160 sp TRI45_MOUSE 29.317 249 153 8 5 239 127 366 8.14E-14 77.8 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R7E5 CHOYP_Y077.1.1 m.27645 sp Y084_OSHVF 98.305 118 2 0 1 118 1 118 8.14E-80 233 Y084_OSHVF reviewed Uncharacterized protein ORF84 ORF84 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 118 0 GO:0016021; GO:0033644 0 0 0 0 Q8JHV9 CHOYP_IAP2.4.5 m.56879 sp BIR7A_XENLA 29.582 311 157 7 1179 1475 139 401 8.14E-39 153 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q8JIU7 CHOYP_NACA.4.9 m.38541 sp NACA_DANRE 73.05 141 30 3 1 133 1 141 8.14E-55 174 NACA_DANRE reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Danio rerio (Zebrafish) (Brachydanio rerio) 215 myofibril assembly [GO:0030239]; protein transport [GO:0015031] GO:0005634; GO:0005737; GO:0015031; GO:0030239 0 0 0 PF01849; P36241 CHOYP_LOC100377332.1.2 m.5678 sp RL19_DROME 69.919 123 37 0 1 123 76 198 8.15E-49 157 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P36241 CHOYP_PSMD1.1.1 m.21687 sp RL19_DROME 69.919 123 37 0 1 123 76 198 8.15E-49 157 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P36241 CHOYP_contig_035975 m.40707 sp RL19_DROME 69.919 123 37 0 1 123 76 198 8.15E-49 157 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; P68101 CHOYP_IF2A.1.1 m.13279 sp IF2A_RAT 72.787 305 82 1 3 306 4 308 8.15E-165 464 IF2A_RAT reviewed Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) Eif2s1 Eif2a Rattus norvegicus (Rat) 315 aging [GO:0007568]; cellular response to amino acid starvation [GO:0034198]; cellular response to heat [GO:0034605]; cellular response to UV [GO:0034644]; mitophagy in response to mitochondrial depolarization [GO:0098779]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of translational initiation in response to stress [GO:0032057]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of neuron death [GO:1901216]; positive regulation of type B pancreatic cell apoptotic process [GO:2000676]; protein autophosphorylation [GO:0046777]; response to endoplasmic reticulum stress [GO:0034976]; response to manganese-induced endoplasmic reticulum stress [GO:1990737]; translational initiation [GO:0006413]; xenophagy [GO:0098792] GO:0002230; GO:0003743; GO:0005634; GO:0005737; GO:0005840; GO:0005850; GO:0005851; GO:0006413; GO:0007568; GO:0010494; GO:0016020; GO:0032057; GO:0033290; GO:0034198; GO:0034605; GO:0034644; GO:0034976; GO:0043022; GO:0043614; GO:0044207; GO:0044822; GO:0046777; GO:0070062; GO:0097451; GO:0098779; GO:0098792; GO:1901216; GO:1905098; GO:1990737; GO:2000676 0 0 0 PF07541;PF00575; Q3TPE9 CHOYP_NACA.8.9 m.64137 sp ANKY2_MOUSE 35.577 104 54 2 84 174 320 423 8.15E-10 61.6 ANKY2_MOUSE reviewed Ankyrin repeat and MYND domain-containing protein 2 Ankmy2 Mus musculus (Mouse) 440 0 GO:0005929; GO:0019899; GO:0046872 0 0 0 PF12796;PF01753; Q4H3K6 CHOYP_FGFR.1.1 m.12575 sp FGFR_CIOIN 29.111 371 203 11 1026 1349 311 668 8.15E-42 169 FGFR_CIOIN reviewed Fibroblast growth factor receptor (Ci-FGFR) (EC 2.7.10.1) FGFR Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) 747 positive regulation of cell proliferation [GO:0008284] GO:0005007; GO:0005524; GO:0008284; GO:0016021 0 0 0 PF07679;PF07714; Q640K3 CHOYP_NCKP1.4.4 m.53214 sp NCKP1_XENLA 70.079 127 35 2 1 127 1000 1123 8.15E-53 181 NCKP1_XENLA reviewed Nck-associated protein 1 (NAP 1) nckap1 Xenopus laevis (African clawed frog) 1128 0 GO:0016021; GO:0031258 0 0 0 PF09735; Q6RG77 CHOYP_NFYB.2.2 m.59730 sp NFYB_HORSE 58.621 203 76 4 2 198 6 206 8.15E-74 224 NFYB_HORSE reviewed Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) NFYB Equus caballus (Horse) 207 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0043565 0 0 0 PF00808; Q6ZRF8 CHOYP_BRAFLDRAFT_110072.4.8 m.7556 sp RN207_HUMAN 21.354 192 138 5 29 218 114 294 8.15E-09 61.6 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7KVW5 CHOYP_KCNN.1.1 m.29753 sp KCNN_DROME 53.237 278 125 3 15 290 605 879 8.15E-97 307 KCNN_DROME reviewed Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) 927 potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057] GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016021; GO:0016057; GO:0016286; GO:0043025 0 0 0 PF02888;PF07885;PF03530; Q8VI56 CHOYP_LRP1B.2.2 m.54317 sp LRP4_MOUSE 27.721 873 563 29 132 971 512 1349 8.15E-89 323 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q9ESN6 CHOYP_BRAFLDRAFT_117226.2.2 m.32665 sp TRIM2_MOUSE 29.412 204 129 8 71 267 536 731 8.15E-12 68.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAV5 CHOYP_TNR27.2.3 m.56216 sp TNR27_HUMAN 35.87 92 51 3 58 149 6 89 8.15E-06 50.8 TNR27_HUMAN reviewed Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080 Homo sapiens (Human) 297 ectodermal cell differentiation [GO:0010668]; epidermis development [GO:0008544]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; multicellular organism development [GO:0007275]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; tissue development [GO:0009888]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004872; GO:0005031; GO:0005622; GO:0005886; GO:0005887; GO:0007275; GO:0008544; GO:0009888; GO:0010668; GO:0016021; GO:0033209; GO:0043123; GO:0046330; GO:0051092; GO:0072332 0 0 0 PF00020; Q9ULJ7 CHOYP_ANKK1.1.1 m.56194 sp ANR50_HUMAN 33.435 329 208 4 125 444 606 932 8.15E-37 150 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; O96952 CHOYP_THIO.2.2 m.52302 sp THIO_GEOCY 55.556 99 41 2 14 109 8 106 8.16E-33 113 THIO_GEOCY reviewed Thioredoxin (Trx) THIO Geodia cydonium (Sponge) 106 cell redox homeostasis [GO:0045454]; glycerol ether metabolic process [GO:0006662] GO:0005737; GO:0006662; GO:0015035; GO:0045454 0 0 0 PF00085; P33450 CHOYP_HGFAC.1.1 m.5902 sp FAT_DROME 35.616 73 36 2 67 131 4028 4097 8.16E-06 51.6 FAT_DROME reviewed Cadherin-related tumor suppressor (Protein fat) [Cleaved into: Ft-mito] ft CG3352 Drosophila melanogaster (Fruit fly) 5147 "calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion mediated by cadherin [GO:0044331]; cell morphogenesis involved in differentiation [GO:0000904]; cell proliferation [GO:0008283]; equator specification [GO:0045317]; establishment of body hair planar orientation [GO:0048105]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of polarity of larval imaginal disc epithelium [GO:0016336]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; microtubule cytoskeleton organization involved in establishment of planar polarity [GO:0090176]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of growth [GO:0045926]; negative regulation of imaginal disc growth [GO:0045571]; negative regulation of Wnt signaling pathway [GO:0030178]; ommatidial rotation [GO:0016318]; peptide cross-linking [GO:0018149]; pupal development [GO:0035209]; regulation of growth [GO:0040008]; regulation of imaginal disc growth [GO:0045570]; regulation of organ growth [GO:0046620]; regulation of protein localization [GO:0032880]; regulation of tube length, open tracheal system [GO:0035159]; single organismal cell-cell adhesion [GO:0016337]; tissue development [GO:0009888]; wing disc development [GO:0035220]" GO:0000904; GO:0001736; GO:0001737; GO:0004872; GO:0005509; GO:0005739; GO:0005887; GO:0007156; GO:0007157; GO:0007164; GO:0007446; GO:0007447; GO:0007476; GO:0008283; GO:0008285; GO:0009888; GO:0010629; GO:0016021; GO:0016318; GO:0016324; GO:0016336; GO:0016337; GO:0016339; GO:0018149; GO:0030178; GO:0032880; GO:0035159; GO:0035209; GO:0035220; GO:0035329; GO:0040008; GO:0042067; GO:0044331; GO:0045198; GO:0045296; GO:0045317; GO:0045570; GO:0045571; GO:0045926; GO:0046620; GO:0048105; GO:0050839; GO:0090176 0 0 0 PF00028;PF00008;PF00054;PF02210; Q02508 CHOYP_NASP.2.4 m.13404 sp HGV2_HALRO 36.549 539 247 11 11 516 30 506 8.16E-75 248 HGV2_HALRO reviewed Protein HGV2 HGV2 Halocynthia roretzi (Sea squirt) (Cynthia roretzi) 510 multicellular organism development [GO:0007275] GO:0005634; GO:0007275 0 0 0 PF10516;PF00515; Q3SZC1 CHOYP_LOC100619435.2.2 m.52104 sp GRPE1_BOVIN 62.937 143 50 3 115 256 76 216 8.16E-55 178 GRPE1_BOVIN reviewed "GrpE protein homolog 1, mitochondrial (Mt-GrpE#1) (mt-GrpE)" GRPEL1 Bos taurus (Bovine) 217 protein folding [GO:0006457] GO:0000774; GO:0005634; GO:0005759; GO:0006457 0 0 cd00446; PF01025; Q5R806 CHOYP_BRAFLDRAFT_276226.2.2 m.64449 sp PTGR2_PONAB 56.034 348 148 3 12 359 5 347 8.16E-137 396 PTGR2_PONAB reviewed Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) PTGR2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 351 prostaglandin metabolic process [GO:0006693] GO:0005737; GO:0006693; GO:0036132; GO:0047522 0 0 0 PF00107; Q6VEU3 CHOYP_PNO1.2.3 m.47802 sp PNO1_DANRE 74.786 234 54 2 14 242 19 252 8.16E-130 369 PNO1_DANRE reviewed RNA-binding protein PNO1 pno1 zgc:65782 Danio rerio (Zebrafish) (Brachydanio rerio) 252 0 GO:0003723; GO:0005730 0 0 0 PF00013; Q8K259 CHOYP_LOC580518.2.2 m.46835 sp GIN1_MOUSE 28.221 163 114 2 131 293 63 222 8.16E-18 87 GIN1_MOUSE reviewed Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Zinc finger H2C2 domain-containing protein) Gin1 Zh2c2 Mus musculus (Mouse) 518 DNA integration [GO:0015074] GO:0003676; GO:0015074 0 0 0 0 Q9BZ19 CHOYP_NEMVEDRAFT_V1G217884.1.1 m.63569 sp ANR60_HUMAN 28.936 235 144 7 2 223 85 309 8.16E-14 77 ANR60_HUMAN reviewed Ankyrin repeat domain-containing protein 60 ANKRD60 C20orf86 Homo sapiens (Human) 345 0 0 0 0 0 PF12796; Q9UR07 CHOYP_LOC754701.1.7 m.10210 sp TF211_SCHPO 28.902 173 93 9 4 164 1077 1231 8.16E-08 57 TF211_SCHPO reviewed Transposon Tf2-11 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-11 SPBC1289.17 SPBC8E4.11c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; A4IF63 CHOYP_BRAFLDRAFT_255103.16.18 m.59602 sp TRIM2_BOVIN 26.866 134 84 3 342 471 603 726 8.17E-09 61.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; B2RUY7 CHOYP_VWC2.1.3 m.27339 sp VWC2L_HUMAN 42.5 80 39 3 46 119 116 194 8.17E-09 55.5 VWC2L_HUMAN reviewed von Willebrand factor C domain-containing protein 2-like (Brorin-like) VWC2L Homo sapiens (Human) 222 negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of neuron differentiation [GO:0045666] GO:0005615; GO:0030054; GO:0030514; GO:0032281; GO:0045202; GO:0045666 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_86891.1.4 m.20490 sp TRIM3_RAT 25.197 127 87 2 40 166 625 743 8.17E-07 52 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75179 CHOYP_LOC100641396.4.27 m.14268 sp ANR17_HUMAN 35.274 292 175 9 1 282 275 562 8.17E-37 142 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O95271 CHOYP_TNKS1.2.5 m.18808 sp TNKS1_HUMAN 69.818 275 76 3 1 269 1054 1327 8.17E-139 425 TNKS1_HUMAN reviewed Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) TNKS PARP5A PARPL TIN1 TINF1 TNKS1 Homo sapiens (Human) 1327 "cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]" GO:0000139; GO:0000209; GO:0000242; GO:0000775; GO:0000781; GO:0000784; GO:0000922; GO:0003950; GO:0005643; GO:0005794; GO:0005829; GO:0006471; GO:0007052; GO:0007067; GO:0008270; GO:0015031; GO:0016055; GO:0018105; GO:0018107; GO:0031965; GO:0032210; GO:0032212; GO:0042393; GO:0045944; GO:0051028; GO:0051225; GO:0051301; GO:0051973; GO:0070198; GO:0070212; GO:0070213; GO:0090263; GO:1904355; GO:1904357; GO:1904743; GO:1904908 0 0 0 PF00023;PF12796;PF13606;PF00644;PF07647; P24928 CHOYP_BH13620.1.1 m.41020 sp RPB1_HUMAN 78.571 112 21 1 67 175 1852 1963 8.17E-35 139 RPB1_HUMAN reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48) POLR2A POLR2 Homo sapiens (Human) 1970 "7-methylguanosine mRNA capping [GO:0006370]; DNA-templated transcription, termination [GO:0006353]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; gene silencing by RNA [GO:0031047]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of RNA splicing [GO:0033120]; positive regulation of viral transcription [GO:0050434]; regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; somatic stem cell population maintenance [GO:0035019]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0000398; GO:0003677; GO:0003899; GO:0003968; GO:0005634; GO:0005654; GO:0005665; GO:0006283; GO:0006353; GO:0006355; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0008543; GO:0010467; GO:0031047; GO:0031625; GO:0033120; GO:0035019; GO:0042795; GO:0044822; GO:0046872; GO:0050434 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; Q28DX0 CHOYP_QTRTD1.1.1 m.19041 sp QTRD1_XENTR 40.33 424 213 7 18 414 1 411 8.17E-104 317 QTRD1_XENTR reviewed Queuine tRNA-ribosyltransferase accessory subunit (Queuine tRNA-ribosyltransferase domain-containing protein 1) qtrtd1 TEgg038e14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 413 queuosine biosynthetic process [GO:0008616]; tRNA modification [GO:0006400] GO:0005737; GO:0005739; GO:0006400; GO:0008270; GO:0008479; GO:0008616; GO:0042803; GO:0046982 PATHWAY: tRNA modification; tRNA-queuosine biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03043}. 0 0 PF01702; Q2TBI2 CHOYP_CHIN.1.1 m.48043 sp THAP4_BOVIN 34.615 104 59 4 1 96 1 103 8.17E-09 60.8 THAP4_BOVIN reviewed THAP domain-containing protein 4 THAP4 Bos taurus (Bovine) 584 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q3SZ87 CHOYP_ISCW_ISCW008596.1.2 m.8803 sp SSRG_BOVIN 69.149 188 53 2 37 222 1 185 8.17E-93 272 SSRG_BOVIN reviewed Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) SSR3 Bos taurus (Bovine) 185 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005789; GO:0006614; GO:0016021 0 0 0 PF07074; Q5YLG1 CHOYP_NEMVEDRAFT_V1G83869.3.3 m.30283 sp GUNA_BACPU 42.826 460 239 9 273 716 46 497 8.17E-98 318 GUNA_BACPU reviewed "Endoglucanase A (EC 3.2.1.4) (Endo-1,4-beta-glucanase A)" eglA Bacillus pumilus (Bacillus mesentericus) 659 cellulose catabolic process [GO:0030245] GO:0005576; GO:0008810; GO:0030245; GO:0030248 0 0 0 PF00942;PF00759; Q62009 CHOYP_BRAFLDRAFT_127065.6.7 m.30727 sp POSTN_MOUSE 34.221 263 163 7 46 302 110 368 8.17E-37 142 POSTN_MOUSE reviewed Periostin (PN) (Osteoblast-specific factor 2) (OSF-2) Postn Osf2 Mus musculus (Mouse) 838 bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin K [GO:0071307]; extracellular matrix organization [GO:0030198]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; neuron projection extension [GO:1990138]; positive regulation of chemokine (C-C motif) ligand 2 secretion [GO:1904209]; positive regulation of smooth muscle cell migration [GO:0014911]; regulation of Notch signaling pathway [GO:0008593]; regulation of systemic arterial blood pressure [GO:0003073]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to mechanical stimulus [GO:0009612]; response to muscle activity [GO:0014850]; tissue development [GO:0009888] GO:0001666; GO:0001953; GO:0003073; GO:0005578; GO:0005615; GO:0005802; GO:0007155; GO:0008201; GO:0008593; GO:0009612; GO:0009888; GO:0014850; GO:0014911; GO:0030198; GO:0031012; GO:0031594; GO:0032355; GO:0044344; GO:0046872; GO:0050839; GO:0071307; GO:0071356; GO:0071560; GO:1900025; GO:1904209; GO:1990138; GO:1990523 0 0 0 PF02469; Q7TT36 CHOYP_GP125.1.1 m.9522 sp AGRA3_MOUSE 30.914 1116 667 22 95 1143 68 1146 8.17E-165 538 AGRA3_MOUSE reviewed Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125) Adgra3 Gpr125 Mus musculus (Mouse) 1310 cell surface receptor signaling pathway [GO:0007166] GO:0004930; GO:0007166; GO:0009897; GO:0016021 0 0 0 PF00002;PF01825;PF07679;PF13855; Q8BT14 CHOYP_CNOT4.1.1 m.17499 sp CNOT4_MOUSE 55.724 463 154 10 4 460 9 426 8.17E-163 477 CNOT4_MOUSE reviewed CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) Cnot4 Not4 Mus musculus (Mouse) 575 "protein autoubiquitination [GO:0051865]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0004842; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0016874; GO:0030014; GO:0044822; GO:0051865 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00076; A4IF63 CHOYP_BRAFLDRAFT_87334.1.4 m.3552 sp TRIM2_BOVIN 26.891 119 84 2 33 149 627 744 8.18E-07 51.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D3ZGB1 CHOYP_NFAT5.1.1 m.61756 sp NFAT5_RAT 56.364 275 115 2 433 706 289 559 8.18E-93 332 NFAT5_RAT reviewed Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) Nfat5 Rattus norvegicus (Rat) 1548 cytokine production [GO:0001816]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; response to osmotic stress [GO:0006970] GO:0000978; GO:0001077; GO:0001816; GO:0005634; GO:0005654; GO:0005737; GO:0006970; GO:0070884 0 0 0 PF16179;PF00554; P16157 CHOYP_TVAG_168010.23.45 m.51917 sp ANK1_HUMAN 33.101 574 382 1 219 792 187 758 8.18E-87 305 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P36241 CHOYP_ISCW_ISCW013810.2.2 m.19882 sp RL19_DROME 81.416 113 21 0 170 282 26 138 8.18E-58 190 RL19_DROME reviewed 60S ribosomal protein L19 RpL19 M(2)60E CG2746 Drosophila melanogaster (Fruit fly) 203 centrosome duplication [GO:0051298]; mitotic spindle elongation [GO:0000022]; translation [GO:0006412] GO:0000022; GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:0051298 0 0 0 PF01280; Q53T59 CHOYP_BRAFLDRAFT_117263.1.1 m.28027 sp H1BP3_HUMAN 35.484 186 109 3 21 205 4 179 8.18E-31 124 H1BP3_HUMAN reviewed HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3) HS1BP3 Homo sapiens (Human) 392 regulation of apoptotic process [GO:0042981] GO:0005739; GO:0005783; GO:0035091; GO:0042981 0 0 0 PF00787; Q5ZML3 CHOYP_ISCW_ISCW014398.3.3 m.19511 sp SRSF1_CHICK 75 180 36 2 4 182 13 184 8.18E-79 238 SRSF1_CHICK reviewed "Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1)" SRSF1 SFRS1 RCJMB04_1l5 Gallus gallus (Chicken) 257 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005737; GO:0006397; GO:0008380; GO:0016607 0 0 0 PF00076; Q65YR7 CHOYP_CYTA2.2.2 m.31989 sp CYTA2_DICDI 48.864 88 37 3 39 124 14 95 8.18E-18 75.5 CYTA2_DICDI reviewed Cystatin-A2 cpiB DDB_G0280439 Dictyostelium discoideum (Slime mold) 95 proteolysis [GO:0006508] GO:0004869; GO:0005829; GO:0006508 0 0 0 PF00031; Q7Z2W7 CHOYP_TRPM1.4.4 m.63758 sp TRPM8_HUMAN 25.102 490 299 13 560 1014 564 1020 8.18E-38 157 TRPM8_HUMAN reviewed Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) 1104 calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955] GO:0005262; GO:0005789; GO:0005886; GO:0006874; GO:0009409; GO:0009897; GO:0016021; GO:0016048; GO:0045121; GO:0050955; GO:0051289; GO:0070207; GO:0070588 0 0 0 PF00520; Q8BN82 CHOYP_LOC100121099.1.1 m.16147 sp S17A5_MOUSE 46.502 243 126 3 1 242 247 486 8.18E-66 215 S17A5_MOUSE reviewed Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter) Slc17a5 Mus musculus (Mouse) 495 amino acid transport [GO:0006865]; sialic acid transport [GO:0015739] GO:0005737; GO:0005764; GO:0005765; GO:0005886; GO:0006865; GO:0015136; GO:0015293; GO:0015739; GO:0016021; GO:0016023; GO:0030054; GO:0030672 0 0 cd06174; PF07690; Q8N357 CHOYP_S35F6.1.1 m.28093 sp S35F6_HUMAN 55.348 374 153 6 1 371 1 363 8.18E-130 380 S35F6_HUMAN reviewed Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog) SLC35F6 C2orf18 UNQ3047/PRO9863 Homo sapiens (Human) 371 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell proliferation [GO:0008284] GO:0005739; GO:0005765; GO:0008284; GO:0016021; GO:0070062; GO:1901029 0 0 0 PF06027; Q9NUQ7 CHOYP_UFSP2.1.1 m.36906 sp UFSP2_HUMAN 49.028 463 226 5 146 600 9 469 8.18E-152 448 UFSP2_HUMAN reviewed Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-) UFSP2 C4orf20 Homo sapiens (Human) 469 proteolysis [GO:0006508]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146] GO:0005634; GO:0005737; GO:0005783; GO:0006508; GO:0016790; GO:0033146; GO:0071567 0 0 0 PF07910; Q9P1V8 CHOYP_LOC100921205.1.1 m.48834 sp SAM15_HUMAN 44.231 104 56 1 28 129 545 648 8.18E-20 87.8 SAM15_HUMAN reviewed Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15) SAMD15 C14orf174 FAM15A Homo sapiens (Human) 674 0 0 0 0 0 PF07647; Q9WTN6 CHOYP_LOC100001249.1.2 m.3917 sp S22AL_MOUSE 29.241 448 284 11 91 515 115 552 8.18E-58 204 S22AL_MOUSE reviewed Solute carrier family 22 member 21 (Organic cation/carnitine transporter 3) (Solute carrier family 22 member 9) Slc22a21 Octn3 Slc22a9 Mus musculus (Mouse) 564 carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879] GO:0005524; GO:0005777; GO:0005887; GO:0009437; GO:0015226; GO:0015491; GO:0015879; GO:0031231 0 0 cd06174; PF00083; B3DLA6 CHOYP_BRAFLDRAFT_202604.1.1 m.41616 sp DICER_XENTR 45.685 394 194 6 177 561 433 815 8.19E-98 329 DICER_XENTR reviewed Endoribonuclease Dicer (EC 3.1.26.3) dicer1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1893 apoptotic DNA fragmentation [GO:0006309]; pre-miRNA processing [GO:0031054]; production of siRNA involved in RNA interference [GO:0030422]; targeting of mRNA for destruction involved in RNA interference [GO:0030423] GO:0003723; GO:0004386; GO:0004525; GO:0004530; GO:0005524; GO:0005634; GO:0005737; GO:0006309; GO:0016442; GO:0030422; GO:0030423; GO:0031054; GO:0046872; GO:0070578 0 0 cd00593; PF00270;PF03368;PF00271;PF02170;PF00636; O70277 CHOYP_LOC100636374.2.4 m.17342 sp TRIM3_RAT 28.906 128 83 2 435 562 472 591 8.19E-08 58.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P23606 CHOYP_ISCW_ISCW019478.1.1 m.9362 sp TGM1_RAT 33.787 367 232 3 1 367 447 802 8.19E-61 212 TGM1_RAT reviewed Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) Tgm1 Rattus norvegicus (Rat) 824 keratinization [GO:0031424]; peptide cross-linking [GO:0018149]; positive regulation of cell cycle [GO:0045787]; positive regulation of keratinocyte proliferation [GO:0010838] GO:0003810; GO:0010838; GO:0018149; GO:0031224; GO:0031424; GO:0045787; GO:0046872; GO:0070062 0 0 0 PF00927;PF01841;PF00868; Q24306 CHOYP_TIAP2.13.13 m.66128 sp DIAP1_DROME 27.674 430 256 12 43 459 39 426 8.19E-43 160 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q5DRD4 CHOYP_FAT4.6.10 m.40979 sp PCDBI_PANTR 29.921 127 74 4 4 128 210 323 8.19E-08 53.5 PCDBI_PANTR reviewed Protocadherin beta-18 (PCDH-beta-18) (Protocadherin beta-17) PCDHB18 PCDHB17 Pan troglodytes (Chimpanzee) 788 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156] GO:0005509; GO:0005886; GO:0007156; GO:0016021 0 0 0 PF00028;PF08266;PF16492; Q8K4G1 CHOYP_BRAFLDRAFT_136374.1.1 m.51045 sp LTBP4_MOUSE 33.481 451 224 21 3 393 726 1160 8.19E-44 170 LTBP4_MOUSE reviewed Latent-transforming growth factor beta-binding protein 4 (LTBP-4) Ltbp4 Mus musculus (Mouse) 1666 hormone secretion [GO:0046879]; regulation of proteolysis [GO:0030162]; transforming growth factor beta receptor signaling pathway [GO:0007179] GO:0005509; GO:0005578; GO:0005615; GO:0007179; GO:0030162; GO:0031012; GO:0046879; GO:0050431; GO:0070062 0 0 0 PF07645;PF00683; Q9GZQ4 CHOYP_TLR1.2.3 m.25241 sp NMUR2_HUMAN 27.184 309 193 11 55 348 50 341 8.19E-10 63.5 NMUR2_HUMAN reviewed Neuromedin-U receptor 2 (NMU-R2) (G-protein coupled receptor FM-4) (G-protein coupled receptor TGR-1) NMUR2 NMU2R TGR1 Homo sapiens (Human) 415 activation of phospholipase A2 activity by calcium-mediated signaling [GO:0043006]; arachidonic acid secretion [GO:0050482]; calcium ion transport [GO:0006816]; calcium-mediated signaling [GO:0019722]; cell-cell signaling [GO:0007267]; central nervous system development [GO:0007417]; feeding behavior [GO:0007631]; grooming behavior [GO:0007625]; inositol phosphate-mediated signaling [GO:0048016]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of smooth muscle contraction [GO:0006940]; response to pain [GO:0048265] GO:0001607; GO:0002023; GO:0004930; GO:0005229; GO:0005525; GO:0005622; GO:0005886; GO:0006816; GO:0006940; GO:0007200; GO:0007204; GO:0007218; GO:0007267; GO:0007417; GO:0007625; GO:0007631; GO:0016021; GO:0019722; GO:0042924; GO:0043006; GO:0048016; GO:0048265; GO:0050482 0 0 0 PF00001; Q9HA64 CHOYP_KT3K.1.1 m.35822 sp KT3K_HUMAN 66.207 145 47 2 32 175 166 309 8.19E-64 201 KT3K_HUMAN reviewed Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein) (FN3K-RP) (FN3K-related protein) FN3KRP Homo sapiens (Human) 309 post-translational protein modification [GO:0043687] GO:0005829; GO:0016301; GO:0043687 0 0 0 PF03881; A6QLH5 CHOYP_ERI3.1.2 m.37037 sp ERI3_BOVIN 54.091 220 93 5 10 223 116 333 8.20E-75 232 ERI3_BOVIN reviewed ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein) ERI3 PINT1 PRNPIP PRNPIP1 Bos taurus (Bovine) 337 "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" GO:0000467; GO:0004527; GO:0044822; GO:0046872 0 0 0 PF00929; A6YLM6 CHOYP_FABP4.1.2 m.37876 sp FABP4_CEREL 35.385 130 81 2 22 151 3 129 8.20E-17 75.1 FABP4_CEREL reviewed "Fatty acid-binding protein, adipocyte (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)" FABP4 Cervus elaphus (Red deer) 132 regulation of inflammatory response [GO:0050727] GO:0005215; GO:0005504; GO:0005634; GO:0005737; GO:0050727 0 0 0 PF00061; O15040 CHOYP_BRAFLDRAFT_216841.1.4 m.23880 sp TCPR2_HUMAN 40.286 350 201 6 24 369 11 356 8.20E-71 263 TCPR2_HUMAN reviewed Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) 1411 autophagy [GO:0006914] GO:0006914 0 0 0 PF06462; O18756 CHOYP_LOC100370244.1.4 m.24792 sp GLCE_BOVIN 47.628 527 261 9 84 605 101 617 8.20E-175 512 GLCE_BOVIN reviewed D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase) GLCE Bos taurus (Bovine) 617 heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210] GO:0000139; GO:0005794; GO:0015012; GO:0016021; GO:0016857; GO:0030210; GO:0047464; GO:0050379 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis. 0 0 PF06662; P21613 CHOYP_KINH.9.9 m.46891 sp KINH_DORPE 65.957 235 66 5 128 362 711 931 8.20E-78 270 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P39429 CHOYP_LOC100697308.1.1 m.5118 sp TRAF2_MOUSE 36.174 528 281 8 10 529 18 497 8.20E-122 370 TRAF2_MOUSE reviewed TNF receptor-associated factor 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRAF2) Traf2 Mus musculus (Mouse) 501 activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cellular protein complex assembly [GO:0043623]; cellular response to nitric oxide [GO:0071732]; negative regulation of apoptotic process [GO:0043066]; negative regulation of glial cell apoptotic process [GO:0034351]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein heterooligomerization [GO:0051291]; protein homotrimerization [GO:0070207]; protein K63-linked ubiquitination [GO:0070534]; regulation of apoptotic process [GO:0042981]; regulation of immunoglobulin secretion [GO:0051023]; regulation of JNK cascade [GO:0046328]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0000151; GO:0002726; GO:0004842; GO:0005164; GO:0005174; GO:0005737; GO:0005829; GO:0005938; GO:0006915; GO:0007165; GO:0007250; GO:0008270; GO:0009898; GO:0012506; GO:0016874; GO:0019899; GO:0019901; GO:0019903; GO:0030163; GO:0031625; GO:0031996; GO:0032743; GO:0033209; GO:0034351; GO:0035631; GO:0042802; GO:0042981; GO:0043066; GO:0043123; GO:0043507; GO:0043623; GO:0045121; GO:0046328; GO:0046625; GO:0051023; GO:0051091; GO:0051092; GO:0051291; GO:0051865; GO:0070207; GO:0070534; GO:0071732; GO:0090073; GO:0097057; GO:0097300; GO:1903265; GO:1903721; GO:1990604; GO:2001238 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF16673;PF00097;PF02176; Q02427 CHOYP_RBP1.1.2 m.25769 sp RBP1_DROME 70.886 79 23 0 4 82 3 81 8.20E-38 128 RBP1_DROME reviewed RNA-binding protein 1 Rbp1 Rbp11 CG17136 Drosophila melanogaster (Fruit fly) 144 "mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of gene expression [GO:0010468]; regulation of mRNA 3'-end processing [GO:0031440]; regulation of transcriptional start site selection at RNA polymerase II promoter [GO:0001178]; RNA splicing [GO:0008380]" GO:0000166; GO:0000381; GO:0000398; GO:0001178; GO:0003729; GO:0005634; GO:0006376; GO:0008380; GO:0010468; GO:0031440; GO:0035327; GO:0045292 0 0 0 PF00076; Q0VGY8 CHOYP_LOC755512.4.5 m.33020 sp TANC1_MOUSE 41.667 108 63 0 3 110 1099 1206 8.20E-19 83.6 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q20930 CHOYP_LOAG_00377.1.4 m.31811 sp MIG17_CAEEL 32.031 256 153 11 290 528 226 477 8.20E-29 125 MIG17_CAEEL reviewed ADAM family mig-17 (EC 3.4.24.-) (A disintegrin and metalloproteinase mig-17) (Abnormal cell migration protein 17) mig-17 F57B7.4 Caenorhabditis elegans 509 gonad morphogenesis [GO:0035262]; regulation of cell migration [GO:0030334] GO:0004222; GO:0005604; GO:0005615; GO:0030334; GO:0035262; GO:0046872 0 0 0 PF01421; Q3SZZ2 CHOYP_XBP1.3.4 m.37190 sp XBP1_BOVIN 39.526 253 116 9 53 273 14 261 8.20E-34 126 XBP1_BOVIN reviewed "X-box-binding protein 1 (XBP-1) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]" XBP1 Bos taurus (Bovine) 261 adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; cell growth [GO:0016049]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid homeostasis [GO:0055089]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron development [GO:0048666]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; protein destabilization [GO:0031648]; regulation of autophagy [GO:0010506]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription from RNA polymerase II promoter [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000122; GO:0000977; GO:0000981; GO:0001047; GO:0001158; GO:0001525; GO:0001889; GO:0001934; GO:0001935; GO:0002639; GO:0003700; GO:0005634; GO:0005737; GO:0005783; GO:0005829; GO:0006366; GO:0006511; GO:0006990; GO:0007517; GO:0010506; GO:0010508; GO:0010832; GO:0014065; GO:0016049; GO:0030176; GO:0031017; GO:0031062; GO:0031490; GO:0031648; GO:0031670; GO:0032008; GO:0032869; GO:0034599; GO:0034976; GO:0035356; GO:0035924; GO:0042149; GO:0042632; GO:0042993; GO:0043066; GO:0045348; GO:0045579; GO:0045582; GO:0045600; GO:0045944; GO:0046982; GO:0048010; GO:0048666; GO:0051024; GO:0055089; GO:0055092; GO:0060612; GO:0060691; GO:0070059; GO:0071222; GO:0071230; GO:0071332; GO:0071333; GO:0071353; GO:0071375; GO:0071498; GO:0071499; GO:1900100; GO:1900102; GO:1900103; GO:1901800; GO:1901985; GO:1902236; GO:1903489; GO:1990418; GO:2000347; GO:2000353; GO:2000778 0 0 0 PF07716; Q5F4C0 CHOYP_HVCN1.1.4 m.8888 sp HVCN1_CHICK 37.374 99 59 1 183 281 100 195 8.20E-14 73.9 HVCN1_CHICK reviewed Voltage-gated hydrogen channel 1 (Hydrogen voltage-gated channel 1) (HV1) HVCN1 RCJMB04_1c7 Gallus gallus (Chicken) 235 cellular response to pH [GO:0071467]; cellular response to zinc ion [GO:0071294]; proton transport [GO:0015992]; response to pH [GO:0009268]; response to zinc ion [GO:0010043] GO:0005887; GO:0009268; GO:0010043; GO:0015992; GO:0016021; GO:0030171; GO:0071294; GO:0071467 0 0 0 PF00520;PF16799; Q6ITT3 CHOYP_LOC100372236.1.4 m.16991 sp MGT4C_PIG 35.135 481 291 9 4 482 17 478 8.20E-92 290 MGT4C_PIG reviewed "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Sus scrofa (Pig) 478 N-glycan processing [GO:0006491] GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04666; Q6KEQ9 CHOYP_PC11X.2.2 m.61766 sp PC11X_PIG 27.35 234 137 10 367 574 243 469 8.20E-06 52.8 PC11X_PIG reviewed Protocadherin-11 X-linked (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) PCDH11X PCDH11 PCDHX Sus scrofa (Pig) 1117 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of phosphatase activity [GO:0010923] GO:0005509; GO:0005886; GO:0007156; GO:0010923; GO:0016021 0 0 0 PF00028;PF08266;PF08374; Q8BG30 CHOYP_LOC100117054.1.1 m.63421 sp NELFA_MOUSE 45.971 546 251 16 13 539 4 524 8.20E-127 384 NELFA_MOUSE reviewed Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2) Nelfa Whsc2 Whsc2h Mus musculus (Mouse) 530 "negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0032021; GO:0034244; GO:0045944; GO:0051571 0 0 0 0 Q8BJW7 CHOYP_LOC100889179.2.2 m.53351 sp EME1_MOUSE 44.444 144 76 2 2 141 423 566 8.20E-35 129 EME1_MOUSE reviewed Crossover junction endonuclease EME1 (EC 3.1.22.-) Eme1 Mus musculus (Mouse) 570 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to intra-S DNA damage checkpoint signaling [GO:0072429] GO:0000790; GO:0003677; GO:0004519; GO:0005634; GO:0005720; GO:0005730; GO:0005737; GO:0006281; GO:0006310; GO:0046872; GO:0048476; GO:0072429 0 0 0 PF02732; Q95LS7 CHOYP_BRAFLDRAFT_126923.1.1 m.5580 sp CCD96_MACFA 47.11 346 176 2 279 617 210 555 8.20E-96 307 CCD96_MACFA reviewed Coiled-coil domain-containing protein 96 CCDC96 QtsA-18831 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 560 0 GO:0005737; GO:0005815 0 0 0 PF13870; Q9ESD1 CHOYP_RL7A.2.6 m.5689 sp PRSS8_MOUSE 42.471 259 133 7 81 330 35 286 8.20E-60 198 PRSS8_MOUSE reviewed Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain] Prss8 Cap1 Mus musculus (Mouse) 342 positive regulation of sodium ion transport [GO:0010765]; transepithelial transport [GO:0070633] GO:0004252; GO:0005615; GO:0005886; GO:0008236; GO:0010765; GO:0016021; GO:0017080; GO:0019897; GO:0045121; GO:0046658; GO:0070062; GO:0070633 0 0 cd00190; PF00089; Q9TXJ0 CHOYP_LOC100650648.1.2 m.24726 sp CMK1_CAEEL 68.712 326 102 0 1 326 1 326 8.20E-173 486 CMK1_CAEEL reviewed Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) cmk-1 K07A9.2 Caenorhabditis elegans 348 neuron projection morphogenesis [GO:0048812]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of neuron differentiation [GO:0045664]; thermosensory behavior [GO:0040040] GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0032793; GO:0040040; GO:0045664; GO:0045944; GO:0046777; GO:0046872; GO:0048812 0 0 0 PF00069; Q9TXJ0 CHOYP_LOC100650648.2.2 m.41490 sp CMK1_CAEEL 68.712 326 102 0 1 326 1 326 8.20E-173 486 CMK1_CAEEL reviewed Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) cmk-1 K07A9.2 Caenorhabditis elegans 348 neuron projection morphogenesis [GO:0048812]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of neuron differentiation [GO:0045664]; thermosensory behavior [GO:0040040] GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0032793; GO:0040040; GO:0045664; GO:0045944; GO:0046777; GO:0046872; GO:0048812 0 0 0 PF00069; P25490 CHOYP_LOC100378209.1.2 m.7335 sp TYY1_HUMAN 54.988 411 89 10 9 342 21 412 8.21E-130 381 TYY1_HUMAN reviewed Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1) YY1 INO80S Homo sapiens (Human) 414 "cell differentiation [GO:0030154]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to UV-C [GO:0010225]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000400; GO:0000724; GO:0001078; GO:0001158; GO:0003677; GO:0003700; GO:0003713; GO:0003714; GO:0003723; GO:0005634; GO:0006351; GO:0006357; GO:0006974; GO:0007283; GO:0008270; GO:0010225; GO:0010629; GO:0016363; GO:0030154; GO:0031011; GO:0034644; GO:0044212; GO:0046332 0 0 0 PF00096; Q08DU8 CHOYP_LOC762368.1.1 m.8991 sp BL1S6_BOVIN 47.692 130 68 0 54 183 43 172 8.21E-28 105 BL1S6_BOVIN reviewed Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) BLOC1S6 PA PLDN Bos taurus (Bovine) 172 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; blood coagulation [GO:0007596]; endosome to melanosome transport [GO:0035646]; intracellular transport [GO:0046907]; melanocyte differentiation [GO:0030318]; melanosome transport [GO:0032402]; membrane fusion [GO:0061025]; neuron projection development [GO:0031175]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of pigment cell differentiation [GO:0050942]; secretion of lysosomal enzymes [GO:0033299] GO:0005654; GO:0005737; GO:0005768; GO:0007596; GO:0008089; GO:0019898; GO:0030133; GO:0030318; GO:0031083; GO:0031175; GO:0031201; GO:0032402; GO:0032816; GO:0033299; GO:0035646; GO:0042803; GO:0046907; GO:0048490; GO:0050942; GO:0051015; GO:0061025; GO:1904115 0 0 0 PF14712; Q17103 CHOYP_MYC.1.2 m.11452 sp MYC_ASTRU 33.411 431 182 16 2 367 13 403 8.21E-41 151 MYC_ASTRU reviewed Myc protein (c-myc) (Fragment) MYC Asterias rubens (Common European starfish) (Asterias vulgaris) 407 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351 0 0 0 PF00010;PF01056; Q24306 CHOYP_LOC100727159.1.1 m.60273 sp DIAP1_DROME 51.765 85 41 0 76 160 218 302 8.21E-24 102 DIAP1_DROME reviewed Death-associated inhibitor of apoptosis 1 (EC 6.3.2.-) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) Diap1 Iap1 th CG12284 Drosophila melanogaster (Fruit fly) 438 antennal morphogenesis [GO:0048800]; apoptotic process [GO:0006915]; border follicle cell migration [GO:0007298]; chaeta morphogenesis [GO:0008407]; germ cell migration [GO:0008354]; inhibition of cysteine-type endopeptidase activity [GO:0097340]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; mitotic spindle assembly [GO:0090307]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of compound eye retinal cell programmed cell death [GO:0046673]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein neddylation [GO:0045116]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; spermatid nucleus differentiation [GO:0007289]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055] GO:0000209; GO:0004842; GO:0004869; GO:0005634; GO:0005737; GO:0005876; GO:0006915; GO:0007275; GO:0007283; GO:0007289; GO:0007298; GO:0007423; GO:0008270; GO:0008354; GO:0008407; GO:0016055; GO:0016874; GO:0031398; GO:0031624; GO:0031625; GO:0042787; GO:0043027; GO:0043066; GO:0043154; GO:0044390; GO:0045035; GO:0045116; GO:0046673; GO:0048800; GO:0051865; GO:0061630; GO:0061663; GO:0070936; GO:0089720; GO:0090263; GO:0090307; GO:0097340; GO:1990001; GO:1990381; GO:2001271 0 0 0 PF00653; Q5DU00 CHOYP_LOC100890540.2.2 m.54188 sp DCDC2_MOUSE 28.536 403 224 14 24 408 18 374 8.21E-35 142 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q6DKC0 CHOYP_ERL2B.1.1 m.187 sp ERL2B_XENLA 73.786 309 78 2 29 336 1 307 8.21E-170 479 ERL2B_XENLA reviewed Erlin-2-B (Endoplasmic reticulum lipid raft-associated protein 2-B) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2-B) (SPFH domain-containing protein 2-B) erlin2-b spfh2-b Xenopus laevis (African clawed frog) 330 cholesterol metabolic process [GO:0008203]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433] GO:0005789; GO:0008203; GO:0016021; GO:0030433 0 0 cd03406; PF01145; Q6ZWJ1 CHOYP_LOC100372510.1.1 m.6762 sp STXB4_HUMAN 33.056 602 303 17 39 623 30 548 8.21E-82 271 STXB4_HUMAN reviewed Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip) STXBP4 Homo sapiens (Human) 553 cellular response to DNA damage stimulus [GO:0006974]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178] GO:0005654; GO:0005737; GO:0006605; GO:0006974; GO:0008286; GO:0010838; GO:0015758; GO:0019905; GO:0045111; GO:0050821; GO:0061178; GO:0070062; GO:1902808 0 0 0 PF00595;PF00397; Q7SYI5 CHOYP_C1GALT1.1.1 m.10743 sp C1GTB_DANRE 39.13 207 118 4 3 207 146 346 8.21E-42 148 C1GTB_DANRE reviewed "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B (EC 2.4.1.122) (Core 1 O-glycan T-synthase B) (Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B) (Core 1 beta1,3-galactosyltransferase 1-B) (C1GalT1-B) (Core 1 beta3-Gal-T1-B)" c1galt1b c1galt1 zgc:66485 Danio rerio (Zebrafish) (Brachydanio rerio) 374 "angiogenesis [GO:0001525]; kidney development [GO:0001822]; O-glycan processing, core 1 [GO:0016267]" GO:0001525; GO:0001822; GO:0016021; GO:0016263; GO:0016267; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02434; Q7Z9I2 CHOYP_LOC101175020.1.1 m.25049 sp YCP9_SCHPO 28.364 275 163 7 1 263 1 253 8.21E-27 107 YCP9_SCHPO reviewed Uncharacterized oxidoreductase C663.09c (EC 1.-.-.-) SPCC663.09c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 253 0 GO:0005634; GO:0005829; GO:0016491 0 0 0 PF00106; Q96LX7 CHOYP_LOC100495562.1.2 m.22991 sp CCD17_HUMAN 28.293 205 117 7 195 392 135 316 8.21E-12 71.2 CCD17_HUMAN reviewed Coiled-coil domain-containing protein 17 CCDC17 Homo sapiens (Human) 622 0 0 0 0 0 0 Q9DFQ7 CHOYP_RL24.5.9 m.43116 sp RL24_GILMI 81.707 82 15 0 2 83 43 124 8.21E-39 130 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; P05539 CHOYP_NELFD.1.1 m.60619 sp CO2A1_RAT 47.196 214 85 4 79 265 733 945 8.22E-24 105 CO2A1_RAT reviewed Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] Col2a1 Rattus norvegicus (Rat) 1419 cartilage development [GO:0051216]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cellular response to mechanical stimulus [GO:0071260]; cellular response to nicotine [GO:0071316]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to retinoic acid [GO:0071300]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vitamin E [GO:0071306]; chondrocyte differentiation [GO:0002062]; growth plate cartilage development [GO:0003417]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to X-ray [GO:0010165] GO:0002062; GO:0003417; GO:0005201; GO:0005585; GO:0005737; GO:0009612; GO:0010165; GO:0046872; GO:0051216; GO:0060351; GO:0071260; GO:0071300; GO:0071306; GO:0071316; GO:0071356; GO:0071374; GO:0071375; GO:0071774 0 0 0 PF01410;PF01391; P18700 CHOYP_LOC373275.2.7 m.14502 sp TBB_STRPU 94.495 109 6 0 1 109 112 220 8.22E-73 221 TBB_STRPU reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Strongylocentrotus purpuratus (Purple sea urchin) 292 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P84169 CHOYP_BRAFLDRAFT_279923.1.1 m.65663 sp PSD13_CHICK 60.533 375 147 1 14 388 2 375 8.22E-165 470 PSD13_CHICK reviewed 26S proteasome non-ATPase regulatory subunit 13 (26S proteasome regulatory subunit RPN9) (26S proteasome regulatory subunit S11) (26S proteasome regulatory subunit p40.5) PSMD13 Gallus gallus (Chicken) 376 proteasome assembly [GO:0043248]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0005198; GO:0005634; GO:0005829; GO:0006511; GO:0008541; GO:0022624; GO:0043248 0 0 0 PF01399; Q03601 CHOYP_BRAFLDRAFT_206799.15.23 m.46261 sp NHL1_CAEEL 25.828 151 106 3 87 231 730 880 8.22E-08 57 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q4KM30 CHOYP_LOC593529.1.1 m.59343 sp DESI1_RAT 53.704 162 74 1 11 172 1 161 8.22E-60 197 DESI1_RAT reviewed Desumoylating isopeptidase 1 (DeSI-1) (EC 3.4.-.-) (PPPDE peptidase domain-containing protein 2) (Protein FAM152B) Desi1 Fam152b Pppde2 Rattus norvegicus (Rat) 168 0 GO:0005634; GO:0005737; GO:0008233 0 0 0 PF05903; Q6JAN1 CHOYP_LOC100366838.1.1 m.22441 sp INVS_CANLF 28.216 684 426 15 5 674 43 675 8.22E-57 212 INVS_CANLF reviewed Inversin (Inversion of embryo turning protein) (Nephrocystin-2) INVS INV NPHP2 Canis lupus familiaris (Dog) (Canis familiaris) 1081 multicellular organism development [GO:0007275]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; Wnt signaling pathway [GO:0016055] GO:0005634; GO:0005737; GO:0005819; GO:0005874; GO:0007275; GO:0016020; GO:0016055; GO:0090090 0 0 0 PF00023;PF12796;PF00612; Q6PBD7 CHOYP_ID2.2.2 m.63671 sp ID2_XENTR 45.556 90 41 3 25 106 14 103 8.22E-18 77 ID2_XENTR reviewed DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2) id2 TTpA010o03.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 132 "cellular senescence [GO:0090398]; embryonic digestive tract morphogenesis [GO:0048557]; endodermal digestive tract morphogenesis [GO:0061031]; negative regulation of gene expression [GO:0010629]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuron fate commitment [GO:0048663]; positive regulation of blood pressure [GO:0045777]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of gene expression [GO:0010628]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0005737; GO:0006351; GO:0010628; GO:0010629; GO:0042752; GO:0043234; GO:0043425; GO:0045665; GO:0045777; GO:0045892; GO:0045893; GO:0048511; GO:0048557; GO:0048661; GO:0048663; GO:0061031; GO:0071158; GO:0090398; GO:2000178 0 0 0 PF00010; Q8CEG5 CHOYP_LOC100373982.1.2 m.51990 sp CC28B_MOUSE 42.202 109 52 2 123 220 78 186 8.22E-20 86.7 CC28B_MOUSE reviewed Coiled-coil domain-containing protein 28B Ccdc28b Mus musculus (Mouse) 200 cilium assembly [GO:0042384] GO:0005737; GO:0005813; GO:0042384 0 0 0 PF13270; Q8WUN7 CHOYP_LOC100372168.1.1 m.9274 sp UBTD2_HUMAN 61.905 231 82 3 1 226 1 230 8.22E-97 285 UBTD2_HUMAN reviewed Ubiquitin domain-containing protein 2 (Dendritic cell-derived ubiquitin-like protein) (DC-UbP) (Ubiquitin-like protein SB72) UBTD2 DCUBP SB72 Homo sapiens (Human) 234 0 GO:0005737 0 0 0 PF16455;PF00240; Q9QXA5 CHOYP_LSM4.3.3 m.58846 sp LSM4_MOUSE 85.149 101 8 2 15 115 1 94 8.22E-58 179 LSM4_MOUSE reviewed U6 snRNA-associated Sm-like protein LSm4 Lsm4 Mus musculus (Mouse) 137 cytoplasmic mRNA processing body assembly [GO:0033962]; mitophagy in response to mitochondrial depolarization [GO:0098779]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of defense response to virus by host [GO:0002230]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; xenophagy [GO:0098792] GO:0000245; GO:0000387; GO:0000932; GO:0000956; GO:0002230; GO:0005654; GO:0005681; GO:0005688; GO:0005737; GO:0017070; GO:0033962; GO:0044822; GO:0097526; GO:0098779; GO:0098792 0 0 0 PF01423; O15027 CHOYP_LOC588883.3.3 m.38321 sp SC16A_HUMAN 42.19 685 311 17 829 1438 1039 1713 8.23E-144 506 SC16A_HUMAN reviewed Protein transport protein Sec16A (SEC16 homolog A) SEC16A KIAA0310 SEC16 SEC16L Homo sapiens (Human) 2179 COPII vesicle coating [GO:0048208]; endoplasmic reticulum organization [GO:0007029]; protein transport [GO:0015031]; substantia nigra development [GO:0021762] GO:0000139; GO:0005737; GO:0005789; GO:0005794; GO:0005829; GO:0007029; GO:0015031; GO:0021762; GO:0048208 0 0 0 PF12932;PF12931; O34309 CHOYP_LOC100890479.1.3 m.8193 sp PPS_BACSU 33.666 401 221 13 444 829 18 388 8.23E-49 192 PPS_BACSU reviewed "Putative phosphoenolpyruvate synthase (Putative PEP synthase) (Pyruvate, water dikinase)" pps BSU18830 Bacillus subtilis (strain 168) 866 0 GO:0005524; GO:0016301 0 0 0 PF00391;PF01326; O61231 CHOYP_LOC100215540.1.1 m.19967 sp RL10_DROME 76.667 210 49 0 7 216 1 210 8.23E-122 347 RL10_DROME reviewed 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0043025; GO:0051297; GO:0051298 0 0 cd01433; PF00252; P02553 CHOYP_RN45S.5.5 m.55877 sp TBA_LYTPI 97.368 114 3 0 1 114 12 125 8.23E-82 240 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P04464 CHOYP_BRAFLDRAFT_124868.1.1 m.34078 sp CALM_WHEAT 54.61 141 63 1 204 344 10 149 8.23E-45 153 CALM_WHEAT reviewed Calmodulin (CaM) 0 Triticum aestivum (Wheat) 149 0 GO:0005509 0 0 0 PF13499; P14248 CHOYP_DCDC2.2.7 m.35512 sp RPB1_PLAFD 32.283 127 81 3 66 189 2259 2383 8.23E-07 52 RPB1_PLAFD reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) RPII Plasmodium falciparum (isolate CDC / Honduras) 2452 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005665; GO:0006366; GO:0046872 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; P35363 CHOYP_LOC578108.1.1 m.36276 sp 5HT2A_MOUSE 22.951 366 228 14 10 364 71 393 8.23E-09 60.5 5HT2A_MOUSE reviewed 5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A) Htr2a Htr2 Mus musculus (Mouse) 471 "activation of phospholipase C activity [GO:0007202]; aging [GO:0007568]; artery smooth muscle contraction [GO:0014824]; behavioral response to cocaine [GO:0048148]; cell death [GO:0008219]; cellular calcium ion homeostasis [GO:0006874]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; memory [GO:0007613]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phospholipase C-activating serotonin receptor signaling pathway [GO:0007208]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glycolytic process [GO:0045821]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol biosynthetic process [GO:0010513]; positive regulation of vasoconstriction [GO:0045907]; protein localization to cytoskeleton [GO:0044380]; regulation of behavior [GO:0050795]; regulation of dopamine secretion [GO:0014059]; regulation of hormone secretion [GO:0046883]; release of sequestered calcium ion into cytosol [GO:0051209]; response to drug [GO:0042493]; serotonin receptor signaling pathway [GO:0007210]; sleep [GO:0030431]; temperature homeostasis [GO:0001659]; urinary bladder smooth muscle contraction [GO:0014832]" GO:0001659; GO:0004993; GO:0005829; GO:0005886; GO:0005887; GO:0005901; GO:0006874; GO:0007202; GO:0007208; GO:0007210; GO:0007568; GO:0007613; GO:0008144; GO:0008219; GO:0008284; GO:0010513; GO:0014059; GO:0014065; GO:0014824; GO:0014832; GO:0016023; GO:0030424; GO:0030431; GO:0033674; GO:0042493; GO:0043025; GO:0043198; GO:0043267; GO:0043406; GO:0044380; GO:0045600; GO:0045821; GO:0045907; GO:0046883; GO:0048148; GO:0050731; GO:0050795; GO:0050965; GO:0050966; GO:0051209; GO:0051378; GO:0051967; GO:0070374; GO:0070852; GO:0071886 0 0 0 PF00001; P57770 CHOYP_AKA10.1.1 m.65296 sp AKA10_PIG 35.191 682 363 17 52 707 11 639 8.23E-115 363 AKA10_PIG reviewed "A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10) (Fragment)" AKAP10 Sus scrofa (Pig) 650 protein localization [GO:0008104] GO:0005739; GO:0008104; GO:0016020 0 0 0 PF00615; Q5UU75 CHOYP_LOC100329077.1.1 m.28473 sp DMTA2_DANRE 36.364 308 151 7 11 278 50 352 8.23E-41 152 DMTA2_DANRE reviewed Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5) dmrta2 dmrt5 Danio rerio (Zebrafish) (Brachydanio rerio) 440 corticotropin hormone secreting cell differentiation [GO:0060128]; sex differentiation [GO:0007548]; telencephalon development [GO:0021537] GO:0000987; GO:0003700; GO:0005634; GO:0007548; GO:0021537; GO:0042803; GO:0046872; GO:0060128 0 0 0 PF00751;PF03474; Q6ZPS2 CHOYP_LOC100557340.1.1 m.25177 sp CRNS1_MOUSE 58.824 85 35 0 2 86 611 695 8.23E-29 111 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q8N0N3 CHOYP_LOC100889837.2.2 m.31074 sp BGBP_PENMO 37.941 340 176 14 123 441 33 358 8.23E-60 202 BGBP_PENMO reviewed "Beta-1,3-glucan-binding protein (GBP)" 0 Penaeus monodon (Giant tiger prawn) 366 carbohydrate metabolic process [GO:0005975]; innate immune response [GO:0045087] GO:0001872; GO:0004553; GO:0005576; GO:0005975; GO:0045087 0 0 0 PF00722; Q8NBJ4 CHOYP_LOC101171417.1.1 m.20914 sp GOLM1_HUMAN 26.619 139 95 2 5 139 3 138 8.23E-08 55.8 GOLM1_HUMAN reviewed Golgi membrane protein 1 (Golgi membrane protein GP73) (Golgi phosphoprotein 2) GOLM1 C9orf155 GOLPH2 PSEC0242 UNQ686/PRO1326 Homo sapiens (Human) 401 nucleus organization [GO:0006997]; regulation of lipid metabolic process [GO:0019216] GO:0005615; GO:0005794; GO:0005887; GO:0006997; GO:0019216; GO:0070062 0 0 0 0 Q9NTG7 CHOYP_LOC100376942.1.1 m.36235 sp SIR3_HUMAN 56.429 280 118 3 73 352 119 394 8.23E-115 355 SIR3_HUMAN reviewed "NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 3.5.1.-) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3)" SIRT3 SIR2L3 Homo sapiens (Human) 399 aerobic respiration [GO:0009060]; mitochondrion organization [GO:0007005]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; peptidyl-lysine deacetylation [GO:0034983]; protein ADP-ribosylation [GO:0006471]; protein deacetylation [GO:0006476] GO:0003950; GO:0005739; GO:0005743; GO:0005759; GO:0006471; GO:0006476; GO:0007005; GO:0008270; GO:0009060; GO:0032041; GO:0034983; GO:0070403; GO:2000757 0 0 0 PF02146; Q9W725 CHOYP_UCP2.3.3 m.14563 sp UCP2_CYPCA 55.618 178 62 5 22 190 10 179 8.23E-55 179 UCP2_CYPCA reviewed Mitochondrial uncoupling protein 2 (UCP 2) (Solute carrier family 25 member 8) ucp2 slc25a8 Cyprinus carpio (Common carp) 310 mitochondrial transport [GO:0006839] GO:0005743; GO:0006839; GO:0016021 0 0 0 PF00153; A7Y2X0 CHOYP_DGRI_GH22876.1.3 m.50288 sp SC6A5_XENLA 49.612 129 62 2 1 128 506 632 8.24E-34 127 SC6A5_XENLA reviewed Sodium- and chloride-dependent glycine transporter 2 (GlyT-2) (GlyT2) (xGlyT2) (Solute carrier family 6 member 5) slc6a5 glyt2 Xenopus laevis (African clawed frog) 790 0 GO:0005328; GO:0005886; GO:0016021; GO:0046872 0 0 0 PF00209; D2GXS7 CHOYP_LOC100374741.38.83 m.33464 sp TRIM2_AILME 31.25 112 75 1 18 127 631 742 8.24E-11 61.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E1BD59 CHOYP_LOC100632153.5.6 m.64797 sp TRI56_BOVIN 22.327 318 199 11 9 306 12 301 8.24E-10 65.5 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; P11833 CHOYP_TBB.5.7 m.60064 sp TBB_PARLI 95.652 253 11 0 1 253 73 325 8.24E-175 491 TBB_PARLI reviewed Tubulin beta chain (Beta-tubulin) 0 Paracentrotus lividus (Common sea urchin) 447 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; P29314 CHOYP_RS9.3.13 m.30475 sp RS9_RAT 89.116 147 12 1 22 164 1 147 8.24E-88 258 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P29590 CHOYP_LOC100880187.3.3 m.53248 sp PML_HUMAN 28.631 241 135 8 12 245 610 820 8.24E-13 71.6 PML_HUMAN reviewed Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19) PML MYL PP8675 RNF71 TRIM19 Homo sapiens (Human) 882 "activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; fibroblast migration [GO:0010761]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of protein localization to chromosome, telomeric region [GO:1904816]; positive regulation of telomere maintenance [GO:0032206]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]" GO:0000784; GO:0001666; GO:0001932; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005829; GO:0006351; GO:0006355; GO:0006461; GO:0006605; GO:0006915; GO:0006919; GO:0006977; GO:0007050; GO:0007179; GO:0007182; GO:0007184; GO:0008270; GO:0008285; GO:0008630; GO:0008631; GO:0009411; GO:0010332; GO:0010522; GO:0010761; GO:0016363; GO:0016525; GO:0016605; GO:0016925; GO:0030099; GO:0030155; GO:0030308; GO:0030578; GO:0031065; GO:0031625; GO:0031901; GO:0031965; GO:0032183; GO:0032206; GO:0032211; GO:0032469; GO:0032922; GO:0032938; GO:0034097; GO:0042406; GO:0042752; GO:0042771; GO:0042803; GO:0043153; GO:0043161; GO:0045087; GO:0045165; GO:0045343; GO:0045892; GO:0045930; GO:0046982; GO:0048146; GO:0048384; GO:0050713; GO:0050821; GO:0050897; GO:0051457; GO:0051607; GO:0051974; GO:0060058; GO:0060333; GO:0060444; GO:0070059; GO:0071353; GO:0090398; GO:0097191; GO:1901796; GO:1902187; GO:1904816; GO:2000059; GO:2000779; GO:2001238 0 0 0 PF12126;PF00643; P91254 CHOYP_LOC100374909.1.2 m.4076 sp GST8_CAEEL 35.644 202 127 1 1 199 1 202 8.24E-39 135 GST8_CAEEL reviewed Probable glutathione S-transferase 8 (EC 2.5.1.18) (GST class-sigma) gst-8 F11G11.1 Caenorhabditis elegans 206 0 GO:0004364 0 0 0 PF14497;PF02798; Q8N264 CHOYP_RHG24.1.2 m.26163 sp RHG24_HUMAN 46.201 329 160 6 6 333 17 329 8.24E-94 306 RHG24_HUMAN reviewed Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP) ARHGAP24 FILGAP Homo sapiens (Human) 748 angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0001525; GO:0005096; GO:0005829; GO:0005856; GO:0005925; GO:0007165; GO:0030154; GO:0042995; GO:0051056 0 0 0 PF00169;PF00620; Q9ERE8 CHOYP_LOC100728554.1.1 m.23489 sp MESD1_MOUSE 34.333 300 185 5 7 297 31 327 8.24E-46 165 MESD1_MOUSE reviewed Mesoderm development candidate 1 Mesdc1 Mus musculus (Mouse) 362 0 0 0 0 0 0 Q9JI18 CHOYP_BRAFLDRAFT_231904.1.1 m.48873 sp LRP1B_MOUSE 40.164 122 66 4 97 212 4237 4357 8.24E-13 75.9 LRP1B_MOUSE reviewed Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT) Lrp1b Lrpdit Mus musculus (Mouse) 4599 in utero embryonic development [GO:0001701] GO:0001701; GO:0005041; GO:0005509; GO:0016020; GO:0016021; GO:0043235; GO:0050750 0 0 0 PF12662;PF16472;PF00008;PF07645;PF00057;PF00058; B0JZG0 CHOYP_BRAFLDRAFT_90196.2.2 m.42787 sp S23A2_XENTR 47.6 250 119 3 29 277 75 313 8.25E-71 233 S23A2_XENTR reviewed Solute carrier family 23 member 2 (Na(+)/L-ascorbic acid transporter 2) (Sodium-dependent vitamin C transporter 2) slc23a2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 649 0 GO:0016021; GO:0070890 0 0 0 PF00860; D3ZQG6 CHOYP_BRAFLDRAFT_98895.2.2 m.39575 sp TRIM2_RAT 30.657 137 60 6 11 128 23 143 8.25E-09 61.6 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P27169 CHOYP_VA0D1.2.2 m.53235 sp PON1_HUMAN 36.438 365 215 6 1 361 4 355 8.25E-66 215 PON1_HUMAN reviewed Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) PON1 PON Homo sapiens (Human) 355 aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; cholesterol metabolic process [GO:0008203]; organophosphate catabolic process [GO:0046434]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of binding [GO:0051099]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of transporter activity [GO:0032411]; response to external stimulus [GO:0009605]; response to fatty acid [GO:0070542]; response to fluoride [GO:1902617]; response to nutrient levels [GO:0031667]; response to toxic substance [GO:0009636] GO:0004063; GO:0004064; GO:0005509; GO:0005543; GO:0005576; GO:0005615; GO:0008203; GO:0009605; GO:0009636; GO:0010875; GO:0019439; GO:0031667; GO:0032411; GO:0034364; GO:0034366; GO:0042803; GO:0043231; GO:0046395; GO:0046434; GO:0046470; GO:0051099; GO:0070062; GO:0070542; GO:0072562; GO:0102007; GO:1902617 0 0 0 PF01731; P34743 CHOYP_BRAFLDRAFT_118451.1.1 m.18929 sp BTG1_CHICK 42.553 94 50 2 1 90 76 169 8.25E-16 72.4 BTG1_CHICK reviewed Protein BTG1 (B-cell translocation gene 1 protein) BTG1 Gallus gallus (Chicken) 170 negative regulation of cell proliferation [GO:0008285]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of myoblast differentiation [GO:0045663] GO:0005634; GO:0005737; GO:0008285; GO:0019899; GO:0045603; GO:0045663; GO:0045766; GO:2000271 0 0 0 PF07742; P51570 CHOYP_BRAFLDRAFT_90953.1.1 m.48786 sp GALK1_HUMAN 58.505 388 158 2 667 1053 7 392 8.25E-161 483 GALK1_HUMAN reviewed Galactokinase (EC 2.7.1.6) (Galactose kinase) GALK1 GALK Homo sapiens (Human) 392 galactitol metabolic process [GO:0019402]; galactose catabolic process [GO:0019388]; galactose metabolic process [GO:0006012]; glycolytic process from galactose [GO:0061623] GO:0004335; GO:0005524; GO:0005534; GO:0005737; GO:0005829; GO:0006012; GO:0016020; GO:0019388; GO:0019402; GO:0061623; GO:0070062 PATHWAY: Carbohydrate metabolism; galactose metabolism. 0 0 PF10509;PF08544;PF00288; Q03650 CHOYP_NEMVEDRAFT_V1G229510.4.4 m.47762 sp CRAM_TRYBB 27.617 554 380 14 80 620 230 775 8.25E-13 75.5 CRAM_TRYBB reviewed "Cysteine-rich, acidic integral membrane protein" CRAM Trypanosoma brucei brucei 945 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021; GO:0020016 0 0 0 PF07016; Q08DY8 CHOYP_ATG13.1.1 m.24322 sp ATG13_BOVIN 37.6 500 255 17 2 467 3 479 8.25E-81 261 ATG13_BOVIN reviewed Autophagy-related protein 13 ATG13 Bos taurus (Bovine) 480 autophagosome assembly [GO:0000045]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of protein targeting to mitochondrion [GO:1903955] GO:0000045; GO:0000407; GO:0005739; GO:0005829; GO:0019901; GO:0098779; GO:1903955; GO:1990316 0 0 0 PF10033; Q49LS8 CHOYP_LOC584966.1.1 m.4948 sp XKR6_TETNG 26.954 371 222 6 108 446 82 435 8.25E-28 119 XKR6_TETNG reviewed XK-related protein 6 xkr6 xrg6 GSTENG00030285001 GSTENG00030286001 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) 578 0 GO:0016021 0 0 0 PF09815; Q6DIB5 CHOYP_LOC753176.3.3 m.54259 sp MEG10_MOUSE 36.437 494 278 23 3 487 344 810 8.25E-65 230 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6TNJ1 CHOYP_KRIT1.1.1 m.17279 sp KRIT1_BOVIN 31.217 756 460 25 10 747 12 725 8.25E-96 317 KRIT1_BOVIN reviewed Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog) KRIT1 CCM1 Bos taurus (Bovine) 736 angiogenesis [GO:0001525]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; regulation of establishment of cell polarity [GO:2000114] GO:0001525; GO:0001937; GO:0005546; GO:0005737; GO:0005874; GO:0005886; GO:0005911; GO:0008017; GO:0010596; GO:0016525; GO:0032403; GO:2000114; GO:2000352 0 0 0 PF00373;PF16705; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.32.34 m.60621 sp VWDE_HUMAN 24.878 615 357 26 57 619 54 615 8.25E-21 103 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NCX0 CHOYP_CCDC150.1.1 m.58800 sp CC150_HUMAN 28.531 1069 624 31 1 958 11 1050 8.25E-68 251 CC150_HUMAN reviewed Coiled-coil domain-containing protein 150 CCDC150 Homo sapiens (Human) 1101 0 0 0 0 0 0 D3K0R6 CHOYP_AT2B4.1.1 m.44966 sp AT2B4_BOVIN 73.377 154 41 0 4 157 137 290 8.26E-71 237 AT2B4_BOVIN reviewed Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 3.6.3.8) ATP2B4 Bos taurus (Bovine) 1207 cellular calcium ion homeostasis [GO:0006874]; sperm motility [GO:0030317] GO:0005388; GO:0005524; GO:0005886; GO:0006874; GO:0016021; GO:0030317; GO:0036126; GO:0046872 0 0 0 PF12424;PF00689;PF00690;PF00122;PF08282; Q06HQ7 CHOYP_PLB1.1.1 m.16558 sp PLB1_MONDO 43.636 330 171 6 77 395 384 709 8.26E-80 270 PLB1_MONDO reviewed "Phospholipase B1, membrane-associated (Phospholipase B) (Phospholipase B/lipase) (PLB/LIP) [Includes: Phospholipase A2 (EC 3.1.1.4); Lysophospholipase (EC 3.1.1.5)]" PLB1 PLB Monodelphis domestica (Gray short-tailed opossum) 1474 lipid catabolic process [GO:0016042] GO:0004622; GO:0004623; GO:0016021; GO:0016042; GO:0016324 0 0 0 PF00657; Q08CS6 CHOYP_CBG04265.1.1 m.54091 sp MOXD2_DANRE 28.226 124 85 2 627 750 46 165 8.26E-09 63.2 MOXD2_DANRE reviewed DBH-like monooxygenase protein 2 homolog (EC 1.14.17.-) moxd2 moxd1l si:ch211-203k16.5 Danio rerio (Zebrafish) (Brachydanio rerio) 572 0 GO:0005507; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q5PPX0 CHOYP_BRAFLDRAFT_124305.1.1 m.53206 sp PPR42_XENLA 45.906 342 174 7 1 337 1 336 8.26E-90 278 PPR42_XENLA reviewed Protein phosphatase 1 regulatory subunit 42 (Leucine-rich repeat-containing protein 67) ppp1r42 lrrc67 Xenopus laevis (African clawed frog) 372 0 GO:0002177; GO:0003779; GO:0005737; GO:0005813; GO:0005815; GO:0015630; GO:0015631; GO:0045502 0 0 0 PF12799; Q70FJ1 CHOYP_LOC100186299.3.6 m.11006 sp AKAP9_MOUSE 34.141 454 285 6 773 1225 1678 2118 8.26E-46 187 AKAP9_MOUSE reviewed A-kinase anchor protein 9 (AKAP-9) (Protein kinase A-anchoring protein 9) (PRKA9) Akap9 Kiaa0803 Mus musculus (Mouse) 3797 microtubule nucleation [GO:0007020]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] GO:0000242; GO:0005737; GO:0005794; GO:0005795; GO:0005813; GO:0007020; GO:0007165; GO:0007283; GO:0036064; GO:0060009 0 0 0 PF10495; Q9H4G4 CHOYP_GAPR1.1.1 m.32196 sp GAPR1_HUMAN 49.342 152 70 4 37 186 7 153 8.26E-41 138 GAPR1_HUMAN reviewed Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) (Golgi-associated PR-1 protein) (Glioma pathogenesis-related protein 2) (GliPR 2) GLIPR2 C9orf19 GAPR1 Homo sapiens (Human) 154 positive regulation of epithelial cell migration [GO:0010634]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of ERK1 and ERK2 cascade [GO:0070374] GO:0000139; GO:0010634; GO:0010718; GO:0042803; GO:0070062; GO:0070374 0 0 0 PF00188; Q9NWU2 CHOYP_LOC100376325.1.2 m.1959 sp GID8_HUMAN 66.079 227 74 1 9 232 2 228 8.26E-98 287 GID8_HUMAN reviewed Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) GID8 C20orf11 Homo sapiens (Human) 228 0 GO:0005654; GO:0030054 0 0 0 PF10607;PF08513; Q9NWU2 CHOYP_LOC100376325.2.2 m.9165 sp GID8_HUMAN 66.079 227 74 1 9 232 2 228 8.26E-98 287 GID8_HUMAN reviewed Glucose-induced degradation protein 8 homolog (Two hybrid-associated protein 1 with RanBPM) (Twa1) GID8 C20orf11 Homo sapiens (Human) 228 0 GO:0005654; GO:0030054 0 0 0 PF10607;PF08513; Q9VUL9 CHOYP_DANA_GF23688.1.1 m.11171 sp FUCTA_DROME 42.045 352 184 11 133 472 142 485 8.26E-83 268 FUCTA_DROME reviewed "Glycoprotein 3-alpha-L-fucosyltransferase A (EC 2.4.1.214) (Core alpha-(1,3)-fucosyltransferase)" FucTA CG6869 Drosophila melanogaster (Fruit fly) 503 nervous system development [GO:0007399]; N-glycan fucosylation [GO:0036071]; protein glycosylation [GO:0006486] GO:0005797; GO:0006486; GO:0007399; GO:0008417; GO:0016021; GO:0018392; GO:0032580; GO:0033932; GO:0036071; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q9W725 CHOYP_UCP2.1.3 m.2638 sp UCP2_CYPCA 54.915 295 116 5 22 307 10 296 8.26E-109 322 UCP2_CYPCA reviewed Mitochondrial uncoupling protein 2 (UCP 2) (Solute carrier family 25 member 8) ucp2 slc25a8 Cyprinus carpio (Common carp) 310 mitochondrial transport [GO:0006839] GO:0005743; GO:0006839; GO:0016021 0 0 0 PF00153; A4FVI0 CHOYP_LOC100078233.1.1 m.26653 sp ZSWM7_DANRE 45.865 133 72 0 34 166 2 134 8.27E-39 132 ZSWM7_DANRE reviewed Zinc finger SWIM domain-containing protein 7 zswim7 si:ch211-31p3.2 Danio rerio (Zebrafish) (Brachydanio rerio) 140 double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0005634; GO:0008270 0 0 0 PF04434; A5YM72 CHOYP_CARNS1.3.6 m.15057 sp CRNS1_HUMAN 36.111 180 106 5 15 185 65 244 8.27E-15 75.5 CRNS1_HUMAN reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) CARNS1 ATPGD1 KIAA1394 Homo sapiens (Human) 827 carnosine biosynthetic process [GO:0035499]; histidine catabolic process [GO:0006548] GO:0005524; GO:0005829; GO:0006548; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 O09174 CHOYP_AMACR.1.1 m.21950 sp AMACR_MOUSE 56.911 369 156 2 1 366 1 369 8.27E-157 449 AMACR_MOUSE reviewed Alpha-methylacyl-CoA racemase (EC 5.1.99.4) (2-methylacyl-CoA racemase) Amacr Macr1 Mus musculus (Mouse) 381 bile acid biosynthetic process [GO:0006699]; bile acid metabolic process [GO:0008206]; fatty acid metabolic process [GO:0006631]; isoprenoid catabolic process [GO:0008300] GO:0005102; GO:0005737; GO:0005739; GO:0005777; GO:0006631; GO:0006699; GO:0008111; GO:0008206; GO:0008300 PATHWAY: Lipid metabolism; bile acid biosynthesis.; PATHWAY: Lipid metabolism; fatty acid metabolism. 0 0 PF02515; P03363 CHOYP_LOC100370766.1.1 m.6596 sp POL_HTLV2 20.667 300 199 7 52 344 602 869 8.27E-08 58.9 POL_HTLV2 reviewed Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol) [Cleaved into: Matrix protein p19 (MA); Capsid protein p24 (CA); Nucleocapsid protein p15-pro (NC') (NC-pro); Protease (PR) (EC 3.4.23.-); p1; Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)] gag-pro-pol Human T-cell leukemia virus 2 (HTLV-2) 1461 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; suppression by virus of host gene expression [GO:0039657]; viral entry into host cell [GO:0046718] GO:0003677; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0005198; GO:0006310; GO:0008270; GO:0015074; GO:0019013; GO:0039657; GO:0046718; GO:0075713 0 0 0 PF02228;PF00607;PF00552;PF02022;PF00075;PF00665;PF00077;PF00078;PF06817;PF00098; P84316 CHOYP_EF-1A.6.9 m.43623 sp EF1A_HELZE 79.268 82 17 0 35 116 131 212 8.27E-40 142 EF1A_HELZE reviewed Elongation factor 1-alpha (EF-1-alpha) (Fragment) 0 Helicoverpa zea (Corn earworm moth) (Heliothis zea) 413 0 GO:0003746; GO:0003924; GO:0005525; GO:0005737 0 0 0 PF03144;PF03143; Q17QS6 CHOYP_LOC754728.2.6 m.26250 sp ASB5_BOVIN 30.075 133 88 2 4 135 138 266 8.27E-10 59.7 ASB5_BOVIN reviewed Ankyrin repeat and SOCS box protein 5 (ASB-5) ASB5 Bos taurus (Bovine) 329 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q5RBR6 CHOYP_LOC577229.1.1 m.14327 sp SPRY3_PONAB 26.57 207 137 7 426 624 71 270 8.27E-08 59.3 SPRY3_PONAB reviewed SPRY domain-containing protein 3 SPRYD3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 442 0 0 0 0 0 PF00622; Q6ZRF8 CHOYP_LOC100374974.3.16 m.3764 sp RN207_HUMAN 20.833 192 139 5 4 193 114 294 8.27E-10 64.3 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8CJ78 CHOYP_ZG20.1.1 m.64480 sp ZN628_MOUSE 40 140 74 4 61 198 447 578 8.27E-24 103 ZN628_MOUSE reviewed Zinc finger protein 628 (Zinc finger protein expressed in embryonal cells and certain adult organs) Znf628 Zec Zfp628 Mus musculus (Mouse) 1038 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096; Q8ITC3 CHOYP_SC6A5.3.7 m.20492 sp RS19_ARGIR 75.887 141 33 1 1 141 1 140 8.27E-77 227 RS19_ARGIR reviewed 40S ribosomal protein S19 RPS19 Argopecten irradians (Bay scallop) (Aequipecten irradians) 144 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01090; Q8K0U4 CHOYP_HS12A.27.33 m.61119 sp HS12A_MOUSE 30.886 722 336 24 10 673 57 673 8.27E-82 275 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q91V01 CHOYP_LPCAT3-A.1.1 m.4985 sp MBOA5_MOUSE 38.057 494 290 6 9 501 8 486 8.27E-115 350 MBOA5_MOUSE reviewed Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (mLPCAT3) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5) Lpcat3 Grcc3f Mboat5 Oact5 Mus musculus (Mouse) 487 phospholipid biosynthetic process [GO:0008654]; regulation of plasma lipoprotein particle levels [GO:0097006] GO:0005789; GO:0008654; GO:0016020; GO:0016021; GO:0047184; GO:0097006 PATHWAY: Lipid metabolism; phospholipid metabolism. 0 0 PF03062; Q9JI12 CHOYP_VGLU2.1.3 m.4108 sp VGLU2_RAT 33.401 494 302 8 25 506 32 510 8.27E-100 317 VGLU2_RAT reviewed Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6) Slc17a6 Dnpi Vglut2 Rattus norvegicus (Rat) 582 brain development [GO:0007420]; hippocampus development [GO:0021766]; neural retina development [GO:0003407]; neurotransmitter uptake [GO:0001504]; sodium ion transport [GO:0006814] GO:0001504; GO:0003407; GO:0005313; GO:0005769; GO:0006814; GO:0007420; GO:0008021; GO:0015293; GO:0016021; GO:0021766; GO:0030054; GO:0030672; GO:0060076; GO:1990030 0 0 cd06174; PF07690; Q9XHH2 CHOYP_LOC580904.1.1 m.29161 sp DNAL1_CHLRE 33.784 148 83 5 16 151 47 191 8.27E-09 60.1 DNAL1_CHLRE reviewed "Dynein light chain 1, axonemal (Flagellar outer arm dynein light chain 1)" LC1 Chlamydomonas reinhardtii (Chlamydomonas smithii) 198 0 GO:0003774; GO:0005737; GO:0005874; GO:0031514; GO:0036157 0 0 0 PF12799; P10079 CHOYP_NOTC1.2.4 m.9965 sp FBP1_STRPU 40.672 268 139 8 60 327 663 910 8.28E-46 176 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P22105 CHOYP_LOC100160385.1.2 m.40193 sp TENX_HUMAN 25.833 240 107 14 21 235 200 393 8.28E-06 51.6 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; Q28298 CHOYP_AGO2.1.1 m.17145 sp RRBP1_CANLF 27.442 215 141 1 70 269 504 718 8.28E-18 93.2 RRBP1_CANLF reviewed Ribosome-binding protein 1 (180 kDa ribosome receptor) (RRp) RRBP1 P180 Canis lupus familiaris (Dog) (Canis familiaris) 1534 protein transport [GO:0015031]; signal transduction [GO:0007165]; translation [GO:0006412] GO:0004872; GO:0005840; GO:0006412; GO:0007165; GO:0015031; GO:0030176 0 0 0 PF05104; Q5E9Z7 CHOYP_LOC100369620.1.1 m.13590 sp RPC4_BOVIN 39.948 383 181 13 12 358 24 393 8.28E-63 208 RPC4_BOVIN reviewed DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) POLR3D Bos taurus (Bovine) 398 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003677; GO:0003899; GO:0005666; GO:0006383; GO:0032728; GO:0045087; GO:0045089; GO:0051607 0 0 0 PF05132; Q6VEU3 CHOYP_PNO1.1.3 m.2044 sp PNO1_DANRE 74.459 231 54 2 14 239 19 249 8.28E-126 362 PNO1_DANRE reviewed RNA-binding protein PNO1 pno1 zgc:65782 Danio rerio (Zebrafish) (Brachydanio rerio) 252 0 GO:0003723; GO:0005730 0 0 0 PF00013; Q8AVY1 CHOYP_BRAFLDRAFT_275083.2.2 m.66604 sp ODF3A_XENLA 55.691 246 106 2 7 252 14 256 8.28E-84 253 ODF3A_XENLA reviewed Outer dense fiber protein 3 (Outer dense fiber of sperm tails protein 3) odf3 Xenopus laevis (African clawed frog) 256 0 GO:0005737 0 0 0 PF07004; Q8K078 CHOYP_LOC100368799.1.1 m.57861 sp SO4A1_MOUSE 33.803 639 384 15 37 652 77 699 8.28E-112 355 SO4A1_MOUSE reviewed Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) Slco4a1 Oatp4a1 Oatpe Slc21a12 Mus musculus (Mouse) 723 organic anion transport [GO:0015711]; sodium-independent organic anion transport [GO:0043252]; thyroid hormone metabolic process [GO:0042403]; thyroid hormone transport [GO:0070327] GO:0005887; GO:0008514; GO:0015347; GO:0015349; GO:0015711; GO:0042403; GO:0043252; GO:0070327 0 0 cd06174; PF07648;PF03137; Q95ZJ1 CHOYP_LOC100748507.1.1 m.34583 sp GALT5_CAEEL 34.961 512 314 13 86 586 107 610 8.28E-96 309 GALT5_CAEEL reviewed Polypeptide N-acetylgalactosaminyltransferase 5 (pp-GaNTase 5) (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 5) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5) gly-5 Y39E4B.12 Caenorhabditis elegans 626 protein O-linked glycosylation via threonine [GO:0018243] GO:0000139; GO:0004653; GO:0016021; GO:0018243; GO:0030246; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535;PF00652; Q96PM5 CHOYP_NEMVEDRAFT_V1G237629.1.1 m.24486 sp ZN363_HUMAN 55.603 232 101 2 8 239 19 248 8.28E-98 292 ZN363_HUMAN reviewed RING finger and CHY zinc finger domain-containing protein 1 (EC 6.3.2.-) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2) RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363 Homo sapiens (Human) 261 error-free translesion synthesis [GO:0070987]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000151; GO:0002039; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0016567; GO:0016607; GO:0016874; GO:0031398; GO:0032436; GO:0042787; GO:0042803; GO:0051865; GO:0070987 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF05495;PF13639; Q98892 CHOYP_LOC725840.1.1 m.54396 sp OBCAM_CHICK 30.663 362 180 15 9 366 10 304 8.28E-32 127 OBCAM_CHICK reviewed Opioid-binding protein/cell adhesion molecule homolog (Neurite inhibitor GP55-A) (OBCAM protein gamma isoform) OPCML Gallus gallus (Chicken) 337 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0031225 0 0 0 PF07679; Q99LZ3 CHOYP_LOC100373647.1.1 m.16586 sp SLD5_MOUSE 57.277 213 89 1 45 257 13 223 8.28E-85 255 SLD5_MOUSE reviewed "DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed]" Gins4 Sld5 Mus musculus (Mouse) 223 DNA duplex unwinding [GO:0032508]; DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]; inner cell mass cell proliferation [GO:0001833] GO:0000727; GO:0000811; GO:0001833; GO:0005634; GO:0005737; GO:0006270; GO:0031298; GO:0032508 0 0 0 PF05916;PF16922; Q9CSU0 CHOYP_LOC100181755.1.1 m.8867 sp RPR1B_MOUSE 49.284 349 152 3 1 349 1 324 8.28E-105 313 RPR1B_MOUSE reviewed Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) Rprd1b Crept Mus musculus (Mouse) 326 "dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle process [GO:0010564]; transcription, DNA-templated [GO:0006351]" GO:0000993; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006351; GO:0008284; GO:0010564; GO:0016591; GO:0045944; GO:0070940 0 0 0 PF16566;PF04818; Q9D7A8 CHOYP_BRAFLDRAFT_125543.1.1 m.18871 sp ARMC1_MOUSE 35.448 268 166 5 45 311 21 282 8.28E-51 172 ARMC1_MOUSE reviewed Armadillo repeat-containing protein 1 Armc1 Mus musculus (Mouse) 282 metal ion transport [GO:0030001] GO:0005634; GO:0005739; GO:0030001; GO:0046872 0 0 0 PF00514; Q9ULJ7 CHOYP_RPS11.5.5 m.66462 sp ANR50_HUMAN 31.333 150 92 2 2 151 721 859 8.28E-16 77.4 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; O01814 CHOYP_LOC100057425.1.1 m.49145 sp FABP5_CAEEL 40.741 135 76 3 10 144 5 135 8.29E-25 95.5 FABP5_CAEEL reviewed Fatty acid-binding protein homolog 5 lbp-5 W02D3.7 Caenorhabditis elegans 136 0 GO:0005215; GO:0005504; GO:0005634; GO:0048471 0 0 0 PF00061; O43895 CHOYP_XPNPEP2.1.1 m.3092 sp XPP2_HUMAN 29.912 682 375 18 56 724 54 645 8.29E-91 301 XPP2_HUMAN reviewed Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2) XPNPEP2 Homo sapiens (Human) 674 0 GO:0004177; GO:0005886; GO:0008237; GO:0016020; GO:0031225; GO:0046872; GO:0070062 0 0 0 PF01321;PF00557;PF16188; P12821 CHOYP_LRP6.3.6 m.21851 sp ACE_HUMAN 46.946 573 280 11 106 670 670 1226 8.29E-171 526 ACE_HUMAN reviewed "Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]" ACE DCP DCP1 Homo sapiens (Human) 1306 angiotensin catabolic process in blood [GO:0002005]; angiotensin maturation [GO:0002003]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; arachidonic acid secretion [GO:0050482]; beta-amyloid metabolic process [GO:0050435]; blood vessel remodeling [GO:0001974]; cell proliferation in bone marrow [GO:0071838]; heart contraction [GO:0060047]; hematopoietic stem cell differentiation [GO:0060218]; hormone catabolic process [GO:0042447]; kidney development [GO:0001822]; mononuclear cell proliferation [GO:0032943]; negative regulation of gap junction assembly [GO:1903597]; neutrophil mediated immunity [GO:0002446]; peptide catabolic process [GO:0043171]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein tyrosine kinase activity [GO:0061098]; regulation of angiotensin metabolic process [GO:0060177]; regulation of blood pressure [GO:0008217]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of renal output by angiotensin [GO:0002019]; regulation of smooth muscle cell migration [GO:0014910]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; regulation of vasoconstriction [GO:0019229]; regulation of vasodilation [GO:0042312]; spermatogenesis [GO:0007283] GO:0001822; GO:0001974; GO:0002003; GO:0002005; GO:0002019; GO:0002446; GO:0002474; GO:0003081; GO:0003779; GO:0004175; GO:0004180; GO:0005576; GO:0005615; GO:0005764; GO:0005768; GO:0005886; GO:0007283; GO:0008144; GO:0008217; GO:0008237; GO:0008238; GO:0008240; GO:0008241; GO:0008270; GO:0009897; GO:0014910; GO:0016021; GO:0019229; GO:0031404; GO:0031434; GO:0031711; GO:0032943; GO:0042312; GO:0042447; GO:0043171; GO:0050435; GO:0050482; GO:0051019; GO:0060047; GO:0060177; GO:0060218; GO:0061098; GO:0070062; GO:0070573; GO:0071838; GO:1900086; GO:1902033; GO:1903597; GO:2000170 0 0 0 PF01401; P29314 CHOYP_BRAFLDRAFT_114843.2.2 m.57234 sp RS9_RAT 86.598 194 16 2 5 188 1 194 8.29E-112 319 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; P58307 CHOYP_LOC100565848.1.1 m.55946 sp OX1R_MOUSE 22.865 363 249 14 9 359 35 378 8.29E-12 69.3 OX1R_MOUSE reviewed Orexin receptor type 1 (Ox-1-R) (Ox1-R) (Ox1R) (Hypocretin receptor type 1) Hcrtr1 Mus musculus (Mouse) 416 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005887; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0016499; GO:0017046; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:0070374; GO:1901652 0 0 0 PF00001; P82596 CHOYP_CLEC10A.3.3 m.27236 sp PLC_HALLA 34.286 140 83 4 39 177 1 132 8.29E-22 89.7 PLC_HALLA reviewed Perlucin 0 Haliotis laevigata (Abalone) 155 0 GO:0030246 0 0 0 PF00059; Q5RAV9 CHOYP_GUAD.1.1 m.33511 sp GUAD_PONAB 51.591 440 201 5 51 480 11 448 8.29E-155 451 GUAD_PONAB reviewed Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) GDA Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 454 guanine catabolic process [GO:0006147] GO:0006147; GO:0008270; GO:0008892 PATHWAY: Purine metabolism; guanine degradation; xanthine from guanine: step 1/1. 0 0 PF01979; Q63931 CHOYP_CCKAR.5.6 m.47791 sp CCKAR_CAVPO 26.893 383 219 16 75 447 49 380 8.29E-13 73.6 CCKAR_CAVPO reviewed Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) CCKAR Cavia porcellus (Guinea pig) 430 0 GO:0004951; GO:0005886; GO:0016021 0 0 0 PF00001;PF09193; Q717B4 CHOYP_CAOG_01182.1.1 m.8019 sp TDPZ3_MOUSE 33.511 188 115 4 149 329 149 333 8.29E-18 86.7 TDPZ3_MOUSE reviewed TD and POZ domain-containing protein 3 Tdpoz3 Mus musculus (Mouse) 365 0 0 0 0 0 PF00651; Q7T3T2 CHOYP_CALM.7.50 m.12029 sp CALM_EPIAK 46.099 141 72 1 28 168 11 147 8.29E-41 137 CALM_EPIAK reviewed Calmodulin (CaM) calm cal1 Epinephelus akaara (Hong Kong grouper) (Serranus akaara) 149 0 GO:0005509 0 0 0 PF13499; Q7Z3U7 CHOYP_LOC587512.1.1 m.21671 sp MON2_HUMAN 49.242 132 66 1 1 131 1586 1717 8.29E-37 135 MON2_HUMAN reviewed Protein MON2 homolog (Protein SF21) MON2 KIAA1040 SF21 Homo sapiens (Human) 1717 Golgi to endosome transport [GO:0006895]; protein transport [GO:0015031] GO:0005829; GO:0006895; GO:0015031; GO:0070062 0 0 0 PF16213;PF09324;PF16206;PF12783; Q8WY54 CHOYP_LOC100694623.1.1 m.14876 sp PPM1E_HUMAN 43.552 411 214 3 79 484 138 535 8.29E-108 352 PPM1E_HUMAN reviewed Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) PPM1E CAMKN KIAA1072 POPX1 Homo sapiens (Human) 764 cellular response to drug [GO:0035690]; negative regulation of protein kinase activity [GO:0006469]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of stress fiber assembly [GO:0051496] GO:0004722; GO:0005634; GO:0005730; GO:0005739; GO:0006469; GO:0035690; GO:0035970; GO:0043234; GO:0046872; GO:0051496 0 0 0 PF00481; Q9VHS7 CHOYP_COQ2.2.3 m.51779 sp COQ2_DROME 58.044 317 128 1 123 434 52 368 8.29E-135 396 COQ2_DROME reviewed "4-hydroxybenzoate polyprenyltransferase, mitochondrial (4-HB polyprenyltransferase) (EC 2.5.1.39) (Coenzyme Q biosynthesis protein 2) (Para-hydroxybenzoate--polyprenyltransferase) (PHB:PPT) (PHB:polyprenyltransferase)" Coq2 CG9613 Drosophila melanogaster (Fruit fly) 392 defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; determination of adult lifespan [GO:0008340]; insulin-like growth factor receptor signaling pathway [GO:0048009]; isoprenoid biosynthetic process [GO:0008299]; transcription from RNA polymerase I promoter [GO:0006360]; ubiquinone biosynthetic process [GO:0006744] GO:0002083; GO:0005666; GO:0005736; GO:0005743; GO:0006360; GO:0006744; GO:0008299; GO:0008340; GO:0008412; GO:0031305; GO:0047293; GO:0048009; GO:0050829; GO:0050830; GO:0050832 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03189}. 0 0 PF01040; O70277 CHOYP_TRIM3.21.58 m.32506 sp TRIM3_RAT 26.877 253 158 11 74 309 465 707 8.30E-15 78.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P09087 CHOYP_CBR-PHP-3.1.1 m.11714 sp ABDB_DROME 66.667 57 19 0 175 231 388 444 8.30E-21 94.4 ABDB_DROME reviewed Homeobox protein abdominal-B (Infraabdominal 7) (IAB-7) (P3) (PH189) Abd-B CG10291 Drosophila melanogaster (Fruit fly) 493 "determination of genital disc primordium [GO:0035225]; developmental pigmentation [GO:0048066]; external genitalia morphogenesis [GO:0035261]; female genitalia development [GO:0030540]; genital disc anterior/posterior pattern formation [GO:0035224]; genital disc development [GO:0035215]; genital disc sexually dimorphic development [GO:0035263]; germ cell migration [GO:0008354]; gonadal mesoderm development [GO:0007506]; heart development [GO:0007507]; imaginal disc-derived female genitalia development [GO:0007486]; imaginal disc-derived genitalia development [GO:0007484]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; male pigmentation [GO:0048094]; midgut development [GO:0007494]; negative regulation of cardioblast cell fate specification [GO:0009997]; negative regulation of female receptivity [GO:0007621]; negative regulation of salivary gland boundary specification [GO:0045705]; negative regulation of striated muscle tissue development [GO:0045843]; neuroendocrine cell differentiation [GO:0061101]; open tracheal system development [GO:0007424]; pole cell migration [GO:0007280]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of developmental pigmentation [GO:0048087]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; salivary gland development [GO:0007431]; segment specification [GO:0007379]; sex differentiation [GO:0007548]; sex-specific pigmentation [GO:0048071]; specification of segmental identity, abdomen [GO:0007385]; sperm storage [GO:0046693]; spiracle morphogenesis, open tracheal system [GO:0035277]; trachea morphogenesis [GO:0060439]" GO:0000976; GO:0000980; GO:0003700; GO:0005634; GO:0007280; GO:0007379; GO:0007385; GO:0007424; GO:0007431; GO:0007484; GO:0007486; GO:0007494; GO:0007506; GO:0007507; GO:0007548; GO:0007621; GO:0008354; GO:0008584; GO:0009997; GO:0030539; GO:0030540; GO:0035215; GO:0035224; GO:0035225; GO:0035261; GO:0035263; GO:0035277; GO:0045705; GO:0045843; GO:0045944; GO:0046693; GO:0048066; GO:0048071; GO:0048087; GO:0048094; GO:0060439; GO:0061101; GO:1902339 0 0 0 PF00046; Q14BN4 CHOYP_SLMAP.1.8 m.88 sp SLMAP_HUMAN 38.668 931 413 26 16 894 3 827 8.30E-156 481 SLMAP_HUMAN reviewed Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein) SLMAP KIAA1601 SLAP UNQ1847/PRO3577 Homo sapiens (Human) 828 muscle contraction [GO:0006936] GO:0005790; GO:0005815; GO:0005887; GO:0006936; GO:0042383 0 0 0 PF00498; Q6DI51 CHOYP_NDK6.1.1 m.835 sp NDK6_DANRE 56.287 167 72 1 39 205 5 170 8.30E-62 193 NDK6_DANRE reviewed Nucleoside diphosphate kinase 6 (NDK 6) (NDP kinase 6) (EC 2.7.4.6) nme6 ndpkz6 Danio rerio (Zebrafish) (Brachydanio rerio) 175 CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] GO:0004550; GO:0005524; GO:0005739; GO:0006183; GO:0006228; GO:0006241; GO:0046872 0 0 0 PF00334; Q8K2L8 CHOYP_LOC100659825.1.1 m.62706 sp TPC12_MOUSE 46.091 486 254 4 329 809 315 797 8.30E-141 438 TPC12_MOUSE reviewed Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) Trappc12 Ttc15 Mus musculus (Mouse) 797 vesicle-mediated transport [GO:0016192] GO:0004175; GO:0005793; GO:0016192 0 0 0 0 Q96L50 CHOYP_LOC100370832.1.1 m.16880 sp LLR1_HUMAN 41.809 409 233 4 1 408 1 405 8.30E-105 319 LLR1_HUMAN reviewed Leucine-rich repeat protein 1 (4-1BB-mediated-signaling molecule) (4-1BBlrr) (LRR-repeat protein 1) (LRR-1) (Peptidylprolyl isomerase-like 5) LRR1 PPIL5 Homo sapiens (Human) 414 protein ubiquitination [GO:0016567] GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12799;PF13516; Q9ULJ7 CHOYP_contig_054800 m.65371 sp ANR50_HUMAN 38.312 154 95 0 1 154 731 884 8.30E-24 99.8 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; Q9V9A7 CHOYP_LOC100222774.1.1 m.56990 sp MCCB_DROME 43.797 532 248 11 56 546 40 561 8.30E-145 432 MCCB_DROME reviewed "Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)" l(2)04524 CG3267 Drosophila melanogaster (Fruit fly) 578 leucine catabolic process [GO:0006552]; regulation of eclosion [GO:0007563] GO:0004485; GO:0005524; GO:0005759; GO:0006552; GO:0007563 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3. 0 0 PF01039; A4IF63 CHOYP_BRAFLDRAFT_88222.4.6 m.51726 sp TRIM2_BOVIN 27.136 199 122 6 277 469 541 722 8.31E-07 55.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O57415 CHOYP_RREB1.1.1 m.11945 sp RREB1_CHICK 39.118 363 184 11 862 1203 607 953 8.31E-62 238 RREB1_CHICK reviewed Ras-responsive element-binding protein 1 (RREB-1) RREB1 Gallus gallus (Chicken) 1615 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003700; GO:0005634; GO:0006355; GO:0006366; GO:0007165; GO:0007275; GO:0043565; GO:0044212; GO:0046872 0 0 0 PF13912; O75179 CHOYP_LOC753709.1.44 m.40 sp ANR17_HUMAN 33.871 496 303 16 2 480 222 709 8.31E-55 201 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75179 CHOYP_TVAG_451090.4.13 m.32854 sp ANR17_HUMAN 37.931 319 155 5 1 278 1090 1406 8.31E-48 174 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P07190 CHOYP_BRAFLDRAFT_220425.4.4 m.49611 sp MAL1_DROME 39.326 534 294 7 69 575 21 551 8.31E-130 395 MAL1_DROME reviewed Maltase A1 (EC 3.2.1.20) (Larval visceral protein H) Mal-A1 LvpH CG8696 Drosophila melanogaster (Fruit fly) 577 0 GO:0004558; GO:0032450 0 0 0 PF00128; P55265 CHOYP_DSRAD.2.4 m.5410 sp DSRAD_HUMAN 48.699 269 123 6 4 257 955 1223 8.31E-75 249 DSRAD_HUMAN reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) 1226 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337] GO:0001649; GO:0001701; GO:0002244; GO:0002566; GO:0003677; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006397; GO:0006606; GO:0006611; GO:0009615; GO:0016020; GO:0016553; GO:0030218; GO:0031054; GO:0035280; GO:0035455; GO:0043066; GO:0044387; GO:0044530; GO:0044822; GO:0045070; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060216; GO:0060337; GO:0060339; GO:0061484; GO:0098586; GO:1900369 0 0 0 PF02137;PF00035;PF02295; P82147 CHOYP_LOC100897892.1.1 m.1462 sp L2EFL_DROME 45.055 91 47 2 84 172 76 165 8.31E-16 74.7 L2EFL_DROME reviewed Protein lethal(2)essential for life (Protein Efl21) l(2)efl CG4533 Drosophila melanogaster (Fruit fly) 187 multicellular organism development [GO:0007275]; protein refolding [GO:0042026]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]; response to heat [GO:0009408]; sarcomere organization [GO:0045214] GO:0007275; GO:0009408; GO:0010998; GO:0030018; GO:0042026; GO:0045214; GO:0048471 0 0 0 PF00011; Q01484 CHOYP_TVAG_123950.9.31 m.32929 sp ANK2_HUMAN 35.106 282 145 3 6 250 45 325 8.31E-47 170 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q0KIA2 CHOYP_TSP_01615.1.1 m.6191 sp Y9801_DROME 45.679 243 129 2 43 282 225 467 8.31E-64 224 Y9801_DROME reviewed PP2C-like domain-containing protein CG9801 CG9801 Drosophila melanogaster (Fruit fly) 709 0 GO:0003824 0 0 0 0 Q12770 CHOYP_BRAFLDRAFT_118545.1.2 m.5624 sp SCAP_HUMAN 36.598 194 105 6 199 391 994 1170 8.31E-24 107 SCAP_HUMAN reviewed Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein) SCAP KIAA0199 PSEC0227 Homo sapiens (Human) 1279 aging [GO:0007568]; cholesterol metabolic process [GO:0008203]; negative regulation of cholesterol biosynthetic process [GO:0045541]; positive regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045716]; regulation of fatty acid biosynthetic process [GO:0042304]; response to hypoxia [GO:0001666]; response to insulin [GO:0032868]; SREBP signaling pathway [GO:0032933] GO:0000139; GO:0001666; GO:0005783; GO:0005789; GO:0005794; GO:0007568; GO:0008203; GO:0012507; GO:0015485; GO:0016021; GO:0032868; GO:0032933; GO:0042304; GO:0043234; GO:0045541; GO:0045716; GO:0051082 0 0 0 PF12349;PF00400; Q149M9 CHOYP_K1239.2.3 m.35823 sp NWD1_HUMAN 34.154 325 189 9 1 305 589 908 8.31E-42 171 NWD1_HUMAN reviewed NACHT domain- and WD repeat-containing protein 1 NWD1 Homo sapiens (Human) 1564 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; Q28CA0 CHOYP_LOC100879407.1.1 m.56224 sp PITC1_XENTR 65.2 250 86 1 1 250 1 249 8.31E-126 363 PITC1_XENTR reviewed Cytoplasmic phosphatidylinositol transfer protein 1 (Retinal degeneration B homolog beta) (RdgBbeta) pitpnc1 TGas018n09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 329 signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0008289; GO:0008526 0 0 0 PF02121; Q5RJ80 CHOYP_C1QL2.6.32 m.4257 sp CAPR2_DANRE 31.618 136 82 3 130 262 785 912 8.31E-10 62.4 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; A2AAY5 CHOYP_BRAFLDRAFT_86624.1.1 m.23279 sp SPD2B_MOUSE 39.831 118 66 2 12 129 132 244 8.32E-20 87 SPD2B_MOUSE reviewed SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) Sh3pxd2b Fad49 Tks4 Mus musculus (Mouse) 908 adipose tissue development [GO:0060612]; bone development [GO:0060348]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; oxidation-reduction process [GO:0055114]; podosome assembly [GO:0071800]; positive regulation of fat cell differentiation [GO:0045600]; protein localization to membrane [GO:0072657]; skeletal system development [GO:0001501]; superoxide metabolic process [GO:0006801] GO:0001501; GO:0001654; GO:0002102; GO:0005737; GO:0006801; GO:0007507; GO:0010314; GO:0016176; GO:0022617; GO:0030054; GO:0030154; GO:0032266; GO:0042169; GO:0042995; GO:0045600; GO:0055114; GO:0060348; GO:0060612; GO:0070273; GO:0071800; GO:0072657; GO:0080025 0 0 0 PF00787;PF00018;PF07653; A4IF63 CHOYP_contig_035260 m.40045 sp TRIM2_BOVIN 22.581 217 150 9 155 361 489 697 8.32E-06 51.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IFJ6 CHOYP_IKZF.1.1 m.55498 sp IKZF5_BOVIN 53.061 49 23 0 568 616 366 414 8.32E-12 71.2 IKZF5_BOVIN reviewed Zinc finger protein Pegasus (Ikaros family zinc finger protein 5) IKZF5 Bos taurus (Bovine) 419 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 0 P10394 CHOYP_LOC100636756.3.4 m.55141 sp POL4_DROME 29.778 225 156 2 411 633 893 1117 8.32E-31 133 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P12394 CHOYP_BRAFLDRAFT_121141.2.2 m.60835 sp CP17A_CHICK 33.819 343 222 5 39 377 38 379 8.32E-56 193 CP17A_CHICK reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Gallus gallus (Chicken) 508 hormone biosynthetic process [GO:0042446]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0008202; GO:0016020; GO:0020037; GO:0042446; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q0IIF6 CHOYP_FAIM1.1.1 m.36651 sp FAIM1_BOVIN 65 180 63 0 40 219 19 198 8.32E-81 243 FAIM1_BOVIN reviewed Fas apoptotic inhibitory molecule 1 FAIM Bos taurus (Bovine) 201 apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066] GO:0005737; GO:0006915; GO:0043066 0 0 0 PF06905; Q504G0 CHOYP_TM127.1.1 m.23816 sp TM127_DANRE 34.783 207 104 2 36 242 23 198 8.32E-37 134 TM127_DANRE reviewed Transmembrane protein 127 tmem127 si:dkey-49h9.5 zgc:109899 Danio rerio (Zebrafish) (Brachydanio rerio) 237 negative regulation of cell proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007] GO:0005886; GO:0008285; GO:0016021; GO:0032007 0 0 0 0 Q5U4X5 CHOYP_NDC80.3.3 m.66776 sp NDC80_XENTR 34.074 135 76 5 45 176 2 126 8.32E-10 60.1 NDC80_XENTR reviewed Kinetochore protein NDC80 homolog (Kinetochore protein Hec1) (Kinetochore-associated protein 2) ndc80 kntc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 640 attachment of mitotic spindle microtubules to kinetochore [GO:0051315]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; establishment of mitotic spindle orientation [GO:0000132]; mitotic spindle organization [GO:0007052] GO:0000132; GO:0000776; GO:0000777; GO:0000778; GO:0005200; GO:0007052; GO:0007059; GO:0031262; GO:0051301; GO:0051315 0 0 0 PF03801; Q61187 CHOYP_TS101.4.4 m.57290 sp TS101_MOUSE 49.539 434 166 8 1 428 1 387 8.32E-138 403 TS101_MOUSE reviewed Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) Tsg101 Mus musculus (Mouse) 391 "cell cycle arrest [GO:0007050]; cell differentiation [GO:0030154]; cell division [GO:0051301]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; keratinocyte differentiation [GO:0030216]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein monoubiquitination [GO:0006513]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]" GO:0000813; GO:0001558; GO:0003714; GO:0005634; GO:0005730; GO:0005737; GO:0005768; GO:0005769; GO:0005770; GO:0005886; GO:0006513; GO:0007050; GO:0008285; GO:0008333; GO:0015031; GO:0030154; GO:0030216; GO:0030374; GO:0031625; GO:0031902; GO:0042803; GO:0043130; GO:0043162; GO:0043405; GO:0045892; GO:0046755; GO:0046790; GO:0048306; GO:0048524; GO:0051301; GO:0070062; GO:1902188; GO:1903543; GO:1903551; GO:1903772; GO:1903774; GO:1990182; GO:2000397 0 0 0 PF05743;PF09454; Q8HYN7 CHOYP_LOC100888051.3.3 m.21341 sp KCIP4_MACFA 57.273 220 87 3 34 247 32 250 8.32E-93 276 KCIP4_MACFA reviewed Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) KCNIP4 KCHIP4 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 250 protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transmembrane transport [GO:1901379] GO:0005244; GO:0005267; GO:0005509; GO:0005829; GO:0005886; GO:0008076; GO:0015459; GO:0072659; GO:1901379 0 0 0 PF13499;PF13833; Q8WV99 CHOYP_LOC588827.1.1 m.11601 sp ZFN2B_HUMAN 47.857 280 122 5 1 280 1 256 8.32E-85 257 ZFN2B_HUMAN reviewed AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) ZFAND2B AIRAPL Homo sapiens (Human) 257 "SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]" GO:0005783; GO:0006616; GO:0008270 0 0 0 PF01428; Q99M80 CHOYP_PTPRT.24.45 m.48718 sp PTPRT_MOUSE 32.432 592 359 13 52 618 731 1306 8.32E-82 287 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9BWM5 CHOYP_LOC100536174.1.1 m.19934 sp ZN416_HUMAN 31.915 235 142 6 80 310 243 463 8.32E-25 107 ZN416_HUMAN reviewed Zinc finger protein 416 ZNF416 Homo sapiens (Human) 594 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912; Q9D0S9 CHOYP_LOC100691034.1.2 m.10976 sp HINT2_MOUSE 68.8 125 38 1 17 140 39 163 8.32E-61 187 HINT2_MOUSE reviewed "Histidine triad nucleotide-binding protein 2, mitochondrial (HINT-2) (EC 3.-.-.-) (HINT-3)" Hint2 Mus musculus (Mouse) 163 apoptotic process [GO:0006915]; steroid biosynthetic process [GO:0006694] GO:0000166; GO:0005730; GO:0005739; GO:0006694; GO:0006915; GO:0016787 0 0 0 PF01230; Q9NL98 CHOYP_ISCW_ISCW010532.2.4 m.35454 sp PRDX_ASCSU 73.846 195 51 0 1 195 1 195 8.32E-109 312 PRDX_ASCSU reviewed Peroxiredoxin (EC 1.11.1.15) (AsPrx) (Thioredoxin peroxidase) 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 195 cell redox homeostasis [GO:0045454]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005737; GO:0006979; GO:0008379; GO:0016209; GO:0045454 0 0 0 PF10417;PF00578; P23359 CHOYP_LOC100329085.1.1 m.25063 sp BMP7_MOUSE 27.986 293 166 7 132 386 144 429 8.33E-32 127 BMP7_MOUSE reviewed Bone morphogenetic protein 7 (BMP-7) (Osteogenic protein 1) (OP-1) Bmp7 Bmp-7 Op1 Mus musculus (Mouse) 430 "anatomical structure formation involved in morphogenesis [GO:0048646]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; branching involved in salivary gland morphogenesis [GO:0060445]; branching morphogenesis of an epithelial tube [GO:0048754]; camera-type eye morphogenesis [GO:0048593]; cartilage development [GO:0051216]; cell development [GO:0048468]; cellular response to BMP stimulus [GO:0071773]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic skeletal joint morphogenesis [GO:0060272]; epithelial cell differentiation [GO:0030855]; eye development [GO:0001654]; growth [GO:0040007]; kidney development [GO:0001822]; mesenchymal cell differentiation [GO:0048762]; mesenchyme development [GO:0060485]; mesoderm formation [GO:0001707]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; metanephric mesenchyme morphogenesis [GO:0072133]; monocyte aggregation [GO:0070487]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell death [GO:0060548]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glomerular mesangial cell proliferation [GO:0072125]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [GO:0072040]; negative regulation of mitotic nuclear division [GO:0045839]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of transcription, DNA-templated [GO:0045892]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neuron projection morphogenesis [GO:0048812]; odontogenesis of dentin-containing tooth [GO:0042475]; organ morphogenesis [GO:0009887]; ossification [GO:0001503]; pattern specification process [GO:0007389]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell death [GO:0010942]; positive regulation of cell differentiation [GO:0045597]; positive regulation of dendrite development [GO:1900006]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of hyaluranon cable assembly [GO:1900106]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization to nucleus [GO:0034504]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of MAPK cascade [GO:0043408]; regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393]; response to estradiol [GO:0032355]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]; salivary gland morphogenesis [GO:0007435]; SMAD protein signal transduction [GO:0060395]; steroid hormone mediated signaling pathway [GO:0043401]; tube morphogenesis [GO:0035239]; ureteric bud development [GO:0001657]" GO:0001503; GO:0001654; GO:0001657; GO:0001707; GO:0001822; GO:0005125; GO:0005160; GO:0005615; GO:0007389; GO:0007411; GO:0007435; GO:0008201; GO:0008285; GO:0009880; GO:0009887; GO:0010800; GO:0010862; GO:0010942; GO:0030326; GO:0030501; GO:0030509; GO:0030855; GO:0031012; GO:0031988; GO:0032355; GO:0033280; GO:0034116; GO:0034504; GO:0035239; GO:0040007; GO:0042326; GO:0042475; GO:0043065; GO:0043401; GO:0043407; GO:0043408; GO:0043434; GO:0045597; GO:0045665; GO:0045666; GO:0045669; GO:0045746; GO:0045786; GO:0045839; GO:0045892; GO:0045893; GO:0045944; GO:0048468; GO:0048593; GO:0048596; GO:0048646; GO:0048754; GO:0048762; GO:0048812; GO:0050768; GO:0051216; GO:0060272; GO:0060393; GO:0060395; GO:0060445; GO:0060485; GO:0060548; GO:0060686; GO:0060687; GO:0070487; GO:0070700; GO:0071773; GO:0072040; GO:0072125; GO:0072133; GO:0072134; GO:0072136; GO:1900006; GO:1900106 0 0 0 PF00019;PF00688; P25787 CHOYP_PSA2.1.1 m.57091 sp PSA2_HUMAN 82.128 235 39 2 19 252 1 233 8.33E-144 405 PSA2_HUMAN reviewed Proteasome subunit alpha type-2 (EC 3.4.25.1) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) PSMA2 HC3 PSC3 Homo sapiens (Human) 234 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; response to virus [GO:0009615]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000165; GO:0000209; GO:0000502; GO:0000932; GO:0002223; GO:0002479; GO:0004298; GO:0005634; GO:0005654; GO:0005829; GO:0005839; GO:0006521; GO:0009615; GO:0019773; GO:0031145; GO:0033209; GO:0038061; GO:0038095; GO:0043161; GO:0043488; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070062; GO:0090090; GO:0090263 0 0 0 PF00227;PF10584; P47752 CHOYP_S1PR2.1.1 m.7431 sp S1PR2_RAT 25.806 310 194 13 4 296 19 309 8.33E-09 59.7 S1PR2_RAT reviewed Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (AGR16) (Endothelial differentiation G-protein coupled receptor 5) (G-protein coupled receptor H218) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5) S1pr2 Edg5 Rattus norvegicus (Rat) 352 actin cytoskeleton reorganization [GO:0031532]; filopodium assembly [GO:0046847]; negative regulation of excitatory postsynaptic potential [GO:0090394]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800] GO:0004930; GO:0005886; GO:0010800; GO:0016021; GO:0031532; GO:0038036; GO:0046847; GO:0090394; GO:1903142 0 0 0 PF00001; P50429 CHOYP_BRAFLDRAFT_206907.10.11 m.57108 sp ARSB_MOUSE 40.499 521 247 10 18 502 39 532 8.33E-134 400 ARSB_MOUSE reviewed Arylsulfatase B (ASB) (EC 3.1.6.12) (N-acetylgalactosamine-4-sulfatase) (G4S) Arsb As1 As1-s Mus musculus (Mouse) 534 colon epithelial cell migration [GO:0061580]; metabolic process [GO:0008152]; positive regulation of neuron projection development [GO:0010976]; regulation of epithelial cell migration [GO:0010632] GO:0003943; GO:0004065; GO:0005764; GO:0008152; GO:0009986; GO:0010632; GO:0010976; GO:0046872; GO:0061580; GO:0070062 0 0 0 PF00884; P52735 CHOYP_LOC733982.1.1 m.37713 sp VAV2_HUMAN 43.471 605 311 11 4 595 2 588 8.33E-160 488 VAV2_HUMAN reviewed Guanine nucleotide exchange factor VAV2 (VAV-2) VAV2 Homo sapiens (Human) 878 angiogenesis [GO:0001525]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of blood coagulation [GO:0030193]; regulation of cell size [GO:0008361]; regulation of gene expression [GO:0010468]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001525; GO:0005085; GO:0005089; GO:0005829; GO:0005886; GO:0007165; GO:0007264; GO:0008361; GO:0010468; GO:0016477; GO:0030032; GO:0030168; GO:0030193; GO:0035023; GO:0038095; GO:0038096; GO:0043065; GO:0043087; GO:0043552; GO:0046872; GO:0048010; GO:0048013; GO:0051056 0 0 0 PF00130;PF11971;PF00169;PF00621;PF00017;PF07653; Q01528 CHOYP_HAAF.8.13 m.31138 sp HAAF_LIMPO 39.884 173 101 2 8 178 1 172 8.33E-43 144 HAAF_LIMPO reviewed Hemagglutinin/amebocyte aggregation factor (18K-LAF) 0 Limulus polyphemus (Atlantic horseshoe crab) 172 0 GO:0005576 0 0 0 0 Q56AP7 CHOYP_NEMVEDRAFT_V1G236806.1.1 m.44714 sp CRBN_RAT 40 75 44 1 115 188 352 426 8.33E-14 72.4 CRBN_RAT reviewed Protein cereblon Crbn Rattus norvegicus (Rat) 445 negative regulation of ion transmembrane transport [GO:0034766]; negative regulation of protein homooligomerization [GO:0032463]; positive regulation of protein homodimerization activity [GO:0090073]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567] GO:0004176; GO:0005634; GO:0005730; GO:0005737; GO:0016020; GO:0016567; GO:0031464; GO:0032463; GO:0034766; GO:0043161; GO:0046872; GO:0090073 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96SW2}. 0 0 PF02190;PF03226; Q5M7P8 CHOYP_TRD7B.1.1 m.56981 sp TDRD7_XENTR 22.103 837 531 24 10 805 1 757 8.33E-29 129 TDRD7_XENTR reviewed Tudor domain-containing protein 7 tdrd7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1077 lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; posttranscriptional regulation of gene expression [GO:0010608]; spermatogenesis [GO:0007283] GO:0002089; GO:0003729; GO:0005737; GO:0007283; GO:0010608; GO:0035770; GO:0070306 0 0 0 PF12872;PF00567; Q6ZMP0 CHOYP_THSD4.1.2 m.36522 sp THSD4_HUMAN 35.049 816 431 22 49 855 287 1012 8.33E-144 454 THSD4_HUMAN reviewed Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6) THSD4 UNQ9334/PRO34005 Homo sapiens (Human) 1018 elastic fiber assembly [GO:0048251] GO:0001527; GO:0004222; GO:0031012; GO:0048251; GO:0070062 0 0 0 PF05986;PF08686;PF00090; Q6ZRF8 CHOYP_LOC100374981.7.16 m.32635 sp RN207_HUMAN 25.389 193 123 8 1 187 117 294 8.33E-11 67.8 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q9BT25 CHOYP_BRAFLDRAFT_69118.1.1 m.66348 sp HAUS8_HUMAN 35.135 111 72 0 463 573 169 279 8.33E-10 64.7 HAUS8_HUMAN reviewed HAUS augmin-like complex subunit 8 (HEC1/NDC80-interacting centrosome-associated protein 1) (Sarcoma antigen NY-SAR-48) HAUS8 HICE1 Homo sapiens (Human) 410 cell division [GO:0051301]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0000086; GO:0000922; GO:0005813; GO:0005829; GO:0005874; GO:0007067; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 0 Q9JK84 CHOYP_LOC587966.1.1 m.10698 sp PAR6G_MOUSE 55.031 318 123 4 13 326 15 316 8.33E-109 325 PAR6G_MOUSE reviewed Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A) Pard6g Par6g Mus musculus (Mouse) 382 cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005737; GO:0005886; GO:0005923; GO:0007049; GO:0051301 0 0 0 PF00564;PF00595; P0CB49 CHOYP_YLPM1.1.2 m.17086 sp YLPM1_RAT 57.229 332 129 6 1212 1534 1049 1376 8.34E-111 387 YLPM1_RAT reviewed YLP motif-containing protein 1 (Nuclear protein ZAP3) Ylpm1 Zap Zap3 Rattus norvegicus (Rat) 1376 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0016607 0 0 0 0 P10994 CHOYP_LOC101470738.1.2 m.2089 sp ACTS_PLEWA 87.342 79 9 1 55 132 22 100 8.34E-43 142 ACTS_PLEWA reviewed "Actin, alpha skeletal muscle (Fragment)" 0 Pleurodeles waltl (Iberian ribbed newt) 125 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q04791 CHOYP_CEL.3.3 m.42337 sp SASB_ANAPL 30.875 583 337 19 4 562 7 547 8.34E-76 254 SASB_ANAPL reviewed "Fatty acyl-CoA hydrolase precursor, medium chain (EC 3.1.2.-) (Thioesterase B)" 0 Anas platyrhynchos (Mallard) (Anas boschas) 557 fatty acid biosynthetic process [GO:0006633] GO:0006633; GO:0016787 0 0 0 PF00135; Q2KJC3 CHOYP_MPEG1.5.5 m.56448 sp MPEG1_BOVIN 36.901 710 400 15 2 691 4 685 8.34E-154 465 MPEG1_BOVIN reviewed Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1) MPEG1 Bos taurus (Bovine) 717 0 GO:0016021 0 0 0 PF01823; Q4R180 CHOYP_LOC100671809.1.1 m.24193 sp ORC3_RAT 40.385 104 62 0 1 104 401 504 8.34E-21 89.7 ORC3_RAT reviewed Origin recognition complex subunit 3 Orc3 Orc3l Rattus norvegicus (Rat) 711 DNA replication initiation [GO:0006270]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267] GO:0000784; GO:0003688; GO:0005656; GO:0005664; GO:0006267; GO:0006270; GO:0031261 0 0 0 PF07034; Q503I2 CHOYP_BRAFLDRAFT_93856.6.6 m.41999 sp TRI13_DANRE 20.747 241 170 6 11 250 50 270 8.34E-06 50.4 TRI13_DANRE reviewed Tripartite motif-containing 13 trim13 zgc:110578 Danio rerio (Zebrafish) (Brachydanio rerio) 404 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q63ZQ1 CHOYP_SEPT2.1.1 m.40428 sp SEP2B_XENLA 57.426 101 30 3 7 107 265 352 8.34E-27 104 SEP2B_XENLA reviewed Septin-2B sept2-b Xenopus laevis (African clawed frog) 352 cell division [GO:0051301]; cilium assembly [GO:0042384]; mitotic nuclear division [GO:0007067]; smoothened signaling pathway [GO:0007224] GO:0005525; GO:0005737; GO:0005819; GO:0007067; GO:0007224; GO:0030496; GO:0032154; GO:0042384; GO:0051301; GO:0060170 0 0 cd01850; PF00735; Q6GPJ8 CHOYP_LOC100368832.1.1 m.59126 sp CEP97_XENLA 45.455 88 48 0 233 320 516 603 8.34E-16 86.3 CEP97_XENLA reviewed Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2) cep97 lrriq2 Xenopus laevis (African clawed frog) 807 cell projection organization [GO:0030030] GO:0005737; GO:0005815; GO:0030030 0 0 0 0 Q9H165 CHOYP_YTDC2.1.1 m.58331 sp BC11A_HUMAN 37.862 552 265 14 329 826 294 821 8.34E-71 253 BC11A_HUMAN reviewed B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856) BCL11A CTIP1 EVI9 KIAA1809 ZNF856 Homo sapiens (Human) 835 "negative regulation of axon extension [GO:0030517]; negative regulation of collateral sprouting [GO:0048671]; negative regulation of dendrite development [GO:2000171]; negative regulation of neuron projection development [GO:0010977]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of collateral sprouting [GO:0048672]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein sumoylation [GO:0016925]; regulation of dendrite development [GO:0050773]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000978; GO:0001078; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0007165; GO:0010976; GO:0010977; GO:0016925; GO:0030517; GO:0032463; GO:0042803; GO:0045944; GO:0046872; GO:0046982; GO:0048671; GO:0048672; GO:0050773; GO:2000171 0 0 0 PF00096; Q9QXP4 CHOYP_LOC592697.1.1 m.45183 sp DONS_MOUSE 41.489 376 193 9 169 533 148 507 8.34E-87 283 DONS_MOUSE reviewed Protein downstream neighbor of Son (Protein 3SG) Donson ORF60 Mus musculus (Mouse) 560 multicellular organism development [GO:0007275] GO:0005634; GO:0007275 0 0 0 0 Q9VC61 CHOYP_LOC100114844.1.1 m.59926 sp CRERF_DROME 50 182 86 3 509 685 558 739 8.34E-48 184 CRERF_DROME reviewed Protein CREBRF homolog CG13624 Drosophila melanogaster (Fruit fly) 755 "positive regulation of transcription, DNA-templated [GO:0045893]; regulation of multicellular organismal metabolic process [GO:0044246]; response to starvation [GO:0042594]; sleep [GO:0030431]; TORC1 signaling [GO:0038202]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0005737; GO:0006351; GO:0030431; GO:0038202; GO:0042594; GO:0042803; GO:0043565; GO:0044246; GO:0045893; GO:0046982 0 0 0 0 O17445 CHOYP_LOC100371985.2.3 m.42480 sp RL15_DROME 74.39 164 42 0 15 178 41 204 8.35E-87 256 RL15_DROME reviewed 60S ribosomal protein L15 RpL15 ZITI CG17420 Drosophila melanogaster (Fruit fly) 204 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0022625 0 0 0 PF00827; O95149 CHOYP_LOC101077787.1.3 m.51929 sp SPN1_HUMAN 44.744 371 190 7 1 368 1 359 8.35E-104 322 SPN1_HUMAN reviewed Snurportin-1 (RNA U transporter 1) SNUPN RNUT1 SPN1 Homo sapiens (Human) 360 nuclear import [GO:0051170]; protein import into nucleus [GO:0006606]; snRNA import into nucleus [GO:0061015]; spliceosomal snRNP assembly [GO:0000387] GO:0000339; GO:0000387; GO:0005643; GO:0005829; GO:0006606; GO:0008565; GO:0051170; GO:0061015; GO:0070062 0 0 0 PF11538; P02553 CHOYP_LOC100366892.1.3 m.17711 sp TBA_LYTPI 99.333 150 1 0 1 150 12 161 8.35E-110 311 TBA_LYTPI reviewed Tubulin alpha chain (Fragment) 0 Lytechinus pictus (Painted sea urchin) 161 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P22105 CHOYP_LOC579946.4.24 m.25358 sp TENX_HUMAN 28.849 617 292 47 220 751 193 747 8.35E-37 153 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P86854 CHOYP_BRAFLDRAFT_80311.1.3 m.18963 sp PLCL_MYTGA 29.932 147 99 4 5 149 12 156 8.35E-22 89 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q21434 CHOYP_LOC100378874.1.1 m.38871 sp NRAMA_CAEEL 45.098 102 55 1 1 101 421 522 8.35E-23 95.5 NRAMA_CAEEL reviewed NRAMP-like transporter smf-1 (Divalent metal transporter smf-1) smf-1 K11G12.4 Caenorhabditis elegans 562 iron ion homeostasis [GO:0055072]; manganese ion homeostasis [GO:0055071]; response to manganese ion [GO:0010042]; response to metal ion [GO:0010038]; transition metal ion transport [GO:0000041] GO:0000041; GO:0010038; GO:0010042; GO:0016021; GO:0016324; GO:0046915; GO:0055071; GO:0055072 0 0 0 PF01566; Q28298 CHOYP_LOC100369294.2.6 m.22959 sp RRBP1_CANLF 28.087 826 467 27 217 999 785 1526 8.35E-32 138 RRBP1_CANLF reviewed Ribosome-binding protein 1 (180 kDa ribosome receptor) (RRp) RRBP1 P180 Canis lupus familiaris (Dog) (Canis familiaris) 1534 protein transport [GO:0015031]; signal transduction [GO:0007165]; translation [GO:0006412] GO:0004872; GO:0005840; GO:0006412; GO:0007165; GO:0015031; GO:0030176 0 0 0 PF05104; Q80YR5 CHOYP_LOC100374524.1.1 m.43463 sp SAFB2_MOUSE 42.553 94 42 2 1 94 32 113 8.35E-07 51.2 SAFB2_MOUSE reviewed Scaffold attachment factor B2 (SAF-B2) Safb2 Mus musculus (Mouse) 991 "regulation of androgen receptor signaling pathway [GO:0060765]; regulation of transcription, DNA-templated [GO:0006355]; Sertoli cell differentiation [GO:0060008]; transcription, DNA-templated [GO:0006351]" GO:0000166; GO:0003677; GO:0005654; GO:0005737; GO:0006351; GO:0006355; GO:0042802; GO:0043231; GO:0044822; GO:0060008; GO:0060765; GO:0070062 0 0 0 PF00076;PF02037; Q8SQC1 CHOYP_LOC100634892.2.2 m.17950 sp SCRB1_PIG 36.247 469 290 5 7 473 8 469 8.35E-103 320 SCRB1_PIG reviewed Scavenger receptor class B member 1 (SRB1) (High density lipoprotein receptor SR-BI) (SR-BI) SCARB1 Sus scrofa (Pig) 509 transcytosis [GO:0045056] GO:0005886; GO:0005901; GO:0016021; GO:0016323; GO:0016324; GO:0045056; GO:0070506 0 0 0 PF01130; Q9ESN6 CHOYP_LOC100369333.6.32 m.23961 sp TRIM2_MOUSE 26.957 230 148 8 266 489 516 731 8.35E-12 71.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9UMY4 CHOYP_HSP7D.3.3 m.41779 sp SNX12_HUMAN 71.429 161 44 1 1 161 1 159 8.35E-83 244 SNX12_HUMAN reviewed Sorting nexin-12 SNX12 Homo sapiens (Human) 172 negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; vesicle organization [GO:0016050] GO:0005769; GO:0010629; GO:0010955; GO:0015031; GO:0016050; GO:0019898; GO:0019899; GO:0030100; GO:0035091; GO:0042177; GO:0051224; GO:0070062; GO:2000642 0 0 0 PF00787; Q9UMY4 CHOYP_LOC100642494.1.1 m.58089 sp SNX12_HUMAN 71.429 161 44 1 1 161 1 159 8.35E-83 244 SNX12_HUMAN reviewed Sorting nexin-12 SNX12 Homo sapiens (Human) 172 negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; vesicle organization [GO:0016050] GO:0005769; GO:0010629; GO:0010955; GO:0015031; GO:0016050; GO:0019898; GO:0019899; GO:0030100; GO:0035091; GO:0042177; GO:0051224; GO:0070062; GO:2000642 0 0 0 PF00787; D3YXG0 CHOYP_BRAFLDRAFT_118067.1.2 m.18290 sp HMCN1_MOUSE 42.735 234 131 2 371 603 4637 4868 8.36E-61 225 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; P11940 CHOYP_PABP4.6.6 m.58056 sp PABP1_HUMAN 76.923 299 68 1 6 304 1 298 8.36E-173 496 PABP1_HUMAN reviewed Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1) PABPC1 PAB1 PABP1 PABPC2 Homo sapiens (Human) 636 "gene silencing by RNA [GO:0031047]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:2000623]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of viral genome replication [GO:0045070]; regulation of mRNA stability [GO:0043488]; translational initiation [GO:0006413]" GO:0000166; GO:0000184; GO:0000289; GO:0000398; GO:0005634; GO:0005737; GO:0005829; GO:0005925; GO:0006378; GO:0006413; GO:0008022; GO:0008143; GO:0008266; GO:0008494; GO:0010494; GO:0016020; GO:0030529; GO:0031047; GO:0036464; GO:0043488; GO:0044822; GO:0045070; GO:0048255; GO:0060213; GO:0070062; GO:0071013; GO:1900153; GO:2000623 0 0 0 PF00658;PF00076; P18756 CHOYP_BRAFLDRAFT_125635.1.1 m.10767 sp ETS1B_XENLA 85.47 117 17 0 445 561 152 268 8.36E-68 223 ETS1B_XENLA reviewed Protein c-ets-1-B (C-ets-1B) (XE1-B) (Fragment) ets1-b Xenopus laevis (African clawed frog) 268 "positive regulation of endothelial cell migration [GO:0010595]; regulation of angiogenesis [GO:0045765]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0010595; GO:0043565; GO:0045765 0 0 0 PF00178; P38542 CHOYP_CPIPJ_CPIJ019028.1.1 m.55702 sp RAN_BRUMA 87.313 134 17 0 2 135 4 137 8.36E-84 248 RAN_BRUMA reviewed GTP-binding nuclear protein Ran (GTPase Ran) (Ras-like protein TC4) Bm1_44725 Brugia malayi (Filarial nematode worm) 215 intracellular protein transport [GO:0006886]; nucleocytoplasmic transport [GO:0006913]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005634; GO:0006886; GO:0006913; GO:0007264 0 0 0 PF00071; P53563 CHOYP_NCL.1.1 m.20006 sp B2CL1_RAT 31.776 107 62 4 568 665 89 193 8.36E-06 51.2 B2CL1_RAT reviewed Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233 aging [GO:0007568]; apoptotic process [GO:0006915]; cerebral cortex development [GO:0021987]; cytokinesis [GO:0000910]; endocytosis [GO:0006897]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; ovarian follicle development [GO:0001541]; regulation of apoptotic process [GO:0042981]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to ischemia [GO:0002931]; response to lead ion [GO:0010288]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434] GO:0000910; GO:0001541; GO:0001666; GO:0002931; GO:0005739; GO:0005740; GO:0005741; GO:0005743; GO:0005759; GO:0005813; GO:0005829; GO:0006897; GO:0006915; GO:0006979; GO:0007093; GO:0007568; GO:0008630; GO:0010035; GO:0010243; GO:0010288; GO:0014070; GO:0016021; GO:0021987; GO:0030054; GO:0030672; GO:0031965; GO:0042542; GO:0042803; GO:0042981; GO:0043027; GO:0043066; GO:0043434; GO:0046982; GO:0051400; GO:0051602; GO:0097192; GO:0097371; GO:2001243 0 0 0 PF00452;PF02180; Q2T9X3 CHOYP_LOC100377663.1.1 m.51028 sp SPRY7_BOVIN 57.868 197 78 2 7 201 3 196 8.36E-89 262 SPRY7_BOVIN reviewed SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein homolog) (CLL deletion region gene 6 protein homolog) SPRYD7 CLLD6 Bos taurus (Bovine) 196 0 0 0 0 0 PF00622; Q460N5 CHOYP_BRAFLDRAFT_91321.10.10 m.59301 sp PAR14_HUMAN 26.623 1694 1104 45 762 2398 189 1800 8.36E-142 493 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q56R14 CHOYP_NEMVEDRAFT_V1G198897.2.6 m.4748 sp TRI33_XENLA 26.59 346 223 7 28 355 97 429 8.36E-20 98.6 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5IFK1 CHOYP_BRAFLDRAFT_123580.1.1 m.64766 sp MCPH1_MACFA 43.243 185 102 1 808 989 656 840 8.36E-40 162 MCPH1_MACFA reviewed Microcephalin MCPH1 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 842 cerebral cortex development [GO:0021987] GO:0005737; GO:0005815; GO:0021987 0 0 0 PF16589;PF12258;PF12738; Q868T3 CHOYP_AAEL_AAEL008652.1.1 m.25034 sp CCAPR_DROME 41.525 236 103 4 1 229 209 416 8.36E-54 184 CCAPR_DROME reviewed Cardioacceleratory peptide receptor (Crustacean cardioactive peptide receptor) CCAP-R CcapR CG33344 Drosophila melanogaster (Fruit fly) 495 "ecdysis, chitin-based cuticle [GO:0018990]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]" GO:0005000; GO:0005887; GO:0007186; GO:0007218; GO:0008188; GO:0016021; GO:0018990 0 0 0 PF00001; Q8CI17 CHOYP_NEMVEDRAFT_V1G207511.4.5 m.51738 sp MB213_MOUSE 27.439 164 104 5 193 349 264 419 8.36E-10 64.7 MB213_MOUSE reviewed Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) 429 0 0 0 0 0 PF03281; Q91YD4 CHOYP_TRPM2.4.12 m.33891 sp TRPM2_MOUSE 26.448 639 369 20 386 972 486 1075 8.36E-41 167 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q92193 CHOYP_ACT.27.27 m.66540 sp ACT_CRAVI 55.696 79 7 2 37 114 73 124 8.36E-16 74.7 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9P2E3 CHOYP_ZNFX1.9.12 m.57701 sp ZNFX1_HUMAN 37.991 637 341 20 26 635 104 713 8.36E-113 375 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9UPN9 CHOYP_BRAFLDRAFT_88224.10.11 m.54237 sp TRI33_HUMAN 23.765 324 221 9 10 318 122 434 8.36E-18 90.9 TRI33_HUMAN reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) 1127 "negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0045892; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; B3EWZ6 CHOYP_NEMVEDRAFT_V1G239043.1.6 m.3615 sp MLRP2_ACRMI 33.275 1142 597 44 592 1663 5 1051 8.37E-137 476 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; P29617 CHOYP_ISCW_ISCW008733.1.1 m.63269 sp PROS_DROME 77.215 158 36 0 647 804 1545 1702 8.37E-81 287 PROS_DROME reviewed Homeobox protein prospero pros CG17228 Drosophila melanogaster (Fruit fly) 1703 "asymmetric cell division [GO:0008356]; asymmetric neuroblast division [GO:0055059]; asymmetric neuroblast division resulting in ganglion mother cell formation [GO:0055060]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; axonogenesis involved in innervation [GO:0060385]; brain development [GO:0007420]; cardiac muscle cell differentiation [GO:0055007]; cell fate commitment [GO:0045165]; cell fate specification [GO:0001708]; central nervous system development [GO:0007417]; compound eye cone cell fate commitment [GO:0042676]; courtship behavior [GO:0007619]; dendrite guidance [GO:0070983]; dendrite morphogenesis [GO:0048813]; eye photoreceptor cell differentiation [GO:0001754]; G1 to G0 transition [GO:0070314]; ganglion mother cell fate determination [GO:0007402]; glial cell differentiation [GO:0010001]; male courtship behavior [GO:0008049]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; neuroblast fate determination [GO:0007400]; neuroblast proliferation [GO:0007405]; peripheral nervous system development [GO:0007422]; phagocytosis [GO:0006909]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization [GO:0008104]; R7 cell fate commitment [GO:0007465]; regulation of neuron differentiation [GO:0045664]; regulation of protein localization to nucleus [GO:1900180]; regulation of R7 cell differentiation [GO:0045676]; regulation of retinal cone cell fate specification [GO:0042673]; regulation of transcription, DNA-templated [GO:0006355]; sensory organ development [GO:0007423]; sensory perception of taste [GO:0050909]; synapse assembly [GO:0007416]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]" GO:0000122; GO:0001078; GO:0001708; GO:0001754; GO:0003677; GO:0003700; GO:0005634; GO:0005875; GO:0005886; GO:0005938; GO:0006351; GO:0006355; GO:0006909; GO:0007399; GO:0007400; GO:0007402; GO:0007405; GO:0007406; GO:0007409; GO:0007411; GO:0007416; GO:0007417; GO:0007419; GO:0007420; GO:0007422; GO:0007423; GO:0007465; GO:0007619; GO:0008049; GO:0008104; GO:0008285; GO:0008356; GO:0010001; GO:0010628; GO:0010629; GO:0042673; GO:0042676; GO:0045165; GO:0045178; GO:0045179; GO:0045180; GO:0045664; GO:0045676; GO:0045944; GO:0048813; GO:0050771; GO:0050909; GO:0055007; GO:0055059; GO:0055060; GO:0060385; GO:0070314; GO:0070983; GO:1900180 0 0 0 PF05044; P43689 CHOYP_TPM.7.19 m.15555 sp TPM2_BIOGL 67.262 168 55 0 1 168 1 168 8.37E-67 208 TPM2_BIOGL reviewed Tropomyosin-2 (Tropomyosin II) (BgTMII) (TMII) 0 Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail) 284 0 0 0 0 0 PF00261; P49326 CHOYP_FMO5.3.6 m.21707 sp FMO5_HUMAN 56.915 188 77 2 3 188 2 187 8.37E-80 249 FMO5_HUMAN reviewed Dimethylaniline monooxygenase [N-oxide-forming] 5 (EC 1.14.13.8) (Dimethylaniline oxidase 5) (Hepatic flavin-containing monooxygenase 5) (FMO 5) FMO5 Homo sapiens (Human) 533 drug metabolic process [GO:0017144] GO:0004499; GO:0005737; GO:0005783; GO:0005789; GO:0016021; GO:0017144; GO:0031090; GO:0050660; GO:0050661 0 0 0 PF00743; Q5BKR2 CHOYP_LOC594676.1.1 m.8936 sp SL9B2_MOUSE 40.536 560 304 8 1 548 1 543 8.37E-133 400 SL9B2_MOUSE reviewed Mitochondrial sodium/hydrogen exchanger 9B2 (Mitochondrial Na(+)/H(+) exchanger NHA2) (NHA-oc) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Sodium/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2) Slc9b2 Nha2 Nhedc2 Mus musculus (Mouse) 547 positive regulation of osteoclast development [GO:2001206]; sodium ion transport [GO:0006814] GO:0006814; GO:0015299; GO:0016021; GO:0031966; GO:2001206 0 0 0 PF00999; Q5I0H9 CHOYP_BRAFLDRAFT_207882.1.1 m.352 sp PDIA5_RAT 43.791 153 80 2 1 147 29 181 8.37E-39 140 PDIA5_RAT reviewed Protein disulfide-isomerase A5 (EC 5.3.4.1) Pdia5 Rattus norvegicus (Rat) 517 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005783; GO:0005788; GO:0006457; GO:0034976; GO:0045454 0 0 0 PF00085; Q75EN0 CHOYP_LOC100893922.1.1 m.20733 sp RAD18_ASHGO 37.5 64 40 0 30 93 26 89 8.37E-07 54.7 RAD18_ASHGO reviewed Postreplication repair E3 ubiquitin-protein ligase RAD18 (EC 6.3.2.-) RAD18 AAR049C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) 443 error-free postreplication DNA repair [GO:0042275]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; mitotic DNA damage checkpoint [GO:0044773]; postreplication repair [GO:0006301]; proteasome localization [GO:0031144]; protein monoubiquitination [GO:0006513]; response to UV [GO:0009411] GO:0000790; GO:0003684; GO:0003697; GO:0005634; GO:0006301; GO:0006513; GO:0008270; GO:0009411; GO:0016874; GO:0031144; GO:0042275; GO:0042276; GO:0043142; GO:0044773; GO:0061630; GO:0070987; GO:0097505 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF02037; Q969V4 CHOYP_LOC100377173.2.2 m.50432 sp TEKT1_HUMAN 54.613 401 182 0 1 401 1 401 8.37E-152 438 TEKT1_HUMAN reviewed Tektin-1 TEKT1 Homo sapiens (Human) 418 0 GO:0005634; GO:0005737; GO:0005874; GO:0005929 0 0 0 0 Q9BY77 CHOYP_LOC582784.1.1 m.53921 sp PDIP3_HUMAN 49.367 79 40 0 389 467 271 349 8.37E-16 83.2 PDIP3_HUMAN reviewed Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR) POLDIP3 KIAA1649 PDIP46 Homo sapiens (Human) 421 mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727]; RNA export from nucleus [GO:0006405]; termination of RNA polymerase II transcription [GO:0006369] GO:0000166; GO:0005654; GO:0005737; GO:0005829; GO:0006369; GO:0006405; GO:0006406; GO:0016607; GO:0016973; GO:0031124; GO:0043231; GO:0044822; GO:0045727 0 0 0 PF00076; P55265 CHOYP_ADAR.3.3 m.60418 sp DSRAD_HUMAN 27.404 416 226 11 6 356 502 906 8.38E-22 100 DSRAD_HUMAN reviewed Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP) ADAR ADAR1 DSRAD G1P1 IFI4 Homo sapiens (Human) 1226 adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337] GO:0001649; GO:0001701; GO:0002244; GO:0002566; GO:0003677; GO:0003726; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0006382; GO:0006397; GO:0006606; GO:0006611; GO:0009615; GO:0016020; GO:0016553; GO:0030218; GO:0031054; GO:0035280; GO:0035455; GO:0043066; GO:0044387; GO:0044530; GO:0044822; GO:0045070; GO:0045071; GO:0045087; GO:0046872; GO:0051607; GO:0060216; GO:0060337; GO:0060339; GO:0061484; GO:0098586; GO:1900369 0 0 0 PF02137;PF00035;PF02295; Q5F3J5 CHOYP_LOC410403.1.1 m.31535 sp PSME3_CHICK 56.017 241 102 3 17 254 14 253 8.38E-95 281 PSME3_CHICK reviewed Proteasome activator complex subunit 3 (Activator of multicatalytic protease subunit 3) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) PSME3 RCJMB04_15e19 RCJMB04_5i13 Gallus gallus (Chicken) 254 negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of endopeptidase activity [GO:0010950]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of proteasomal protein catabolic process [GO:0061136] GO:0000502; GO:0005654; GO:0005737; GO:0008537; GO:0010950; GO:0016020; GO:0061133; GO:0061136; GO:2000045; GO:2001237 0 0 0 PF02251;PF02252; Q5F4A1 CHOYP_LOC100537259.1.2 m.46219 sp G2E3_CHICK 27.612 268 177 5 361 623 444 699 8.38E-15 81.6 G2E3_CHICK reviewed G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) G2E3 RCJMB04_1m6 Gallus gallus (Chicken) 742 apoptotic process [GO:0006915]; multicellular organism development [GO:0007275] GO:0004842; GO:0005730; GO:0005737; GO:0006915; GO:0007275; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q5RBR8 CHOYP_EIF4H.2.3 m.26862 sp IF4H_PONAB 65.041 123 39 2 64 184 29 149 8.38E-42 144 IF4H_PONAB reviewed Eukaryotic translation initiation factor 4H (eIF-4H) EIF4H Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 228 0 GO:0000166; GO:0003743; GO:0048471 0 0 0 PF00076; Q5U259 CHOYP_LOC100533384.4.5 m.44794 sp ELV1B_XENLA 42.396 217 114 2 5 221 19 224 8.38E-57 189 ELV1B_XENLA reviewed ELAV-like protein 1-B (Protein ElrA-B) (ElrA) elavl1-b elavl1 elrA Xenopus laevis (African clawed frog) 326 gastrulation [GO:0007369]; intracellular mRNA localization [GO:0008298]; mRNA stabilization [GO:0048255]; regulation of stem cell population maintenance [GO:2000036] GO:0000166; GO:0003730; GO:0005634; GO:0005737; GO:0005938; GO:0007369; GO:0008266; GO:0008298; GO:0030529; GO:0048255; GO:2000036 0 0 0 PF00076; Q6P9S0 CHOYP_MTSS1.3.5 m.38095 sp MTSSL_MOUSE 59.862 289 112 2 6 294 5 289 8.38E-107 348 MTSSL_MOUSE reviewed MTSS1-like protein Mtss1l Mus musculus (Mouse) 715 lamellipodium organization [GO:0097581]; membrane organization [GO:0061024]; plasma membrane organization [GO:0007009]; ruffle assembly [GO:0097178] GO:0001726; GO:0003785; GO:0005546; GO:0005886; GO:0007009; GO:0030027; GO:0030864; GO:0048365; GO:0061024; GO:0097178; GO:0097581 0 0 0 PF08397; Q895K2 CHOYP_LOC100377759.6.15 m.27118 sp DPO3_CLOTE 29.319 191 111 9 68 254 407 577 8.38E-09 59.7 DPO3_CLOTE reviewed DNA polymerase III PolC-type (PolIII) (EC 2.7.7.7) polC CTC_01271 Clostridium tetani (strain Massachusetts / E88) 1427 DNA-dependent DNA replication [GO:0006261] GO:0003677; GO:0003887; GO:0005737; GO:0006261; GO:0008408 0 0 0 PF11490;PF07733;PF14579;PF02811;PF00929;PF01336; Q9HBL0 CHOYP_TENS3.2.4 m.45659 sp TENS1_HUMAN 46.448 366 170 5 8 348 6 370 8.38E-108 380 TENS1_HUMAN reviewed Tensin-1 TNS1 TNS Homo sapiens (Human) 1735 cell-substrate junction assembly [GO:0007044]; fibroblast migration [GO:0010761] GO:0005737; GO:0005856; GO:0005925; GO:0007044; GO:0009986; GO:0010761; GO:0044822 0 0 0 PF08416;PF10409;PF00017; A6QQ68 CHOYP_LOC100372845.2.3 m.23241 sp F228B_BOVIN 29.167 240 143 5 90 325 27 243 8.39E-24 102 F228B_BOVIN reviewed Protein FAM228B FAM228B Bos taurus (Bovine) 264 0 0 0 0 0 0 C3XVM1 CHOYP_GATC.2.2 m.30174 sp GATC_BRAFL 58.14 129 54 0 10 138 17 145 8.39E-48 154 GATC_BRAFL reviewed "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-)" BRAFLDRAFT_270748 Branchiostoma floridae (Florida lancelet) (Amphioxus) 149 glutaminyl-tRNAGln biosynthesis via transamidation [GO:0070681]; mitochondrial translation [GO:0032543]; regulation of translational fidelity [GO:0006450] GO:0005524; GO:0005739; GO:0006450; GO:0030956; GO:0032543; GO:0050567; GO:0070681 0 0 0 PF02686; D2HBJ8 CHOYP_LOC100375318.1.1 m.9357 sp UBP44_AILME 43.441 709 271 19 1 613 4 678 8.39E-178 526 UBP44_AILME reviewed Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44) USP44 PANDA_007904 Ailuropoda melanoleuca (Giant panda) 711 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090266]; regulation of spindle checkpoint [GO:0090231] GO:0004843; GO:0005634; GO:0005730; GO:0007067; GO:0008270; GO:0015630; GO:0016579; GO:0043161; GO:0051301; GO:0090231; GO:0090266; GO:1904667 0 0 0 PF00443;PF02148; D3YXG0 CHOYP_HMCN1.7.44 m.13810 sp HMCN1_MOUSE 28.333 480 295 13 6 476 662 1101 8.39E-38 151 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O01761 CHOYP_contig_007002 m.8026 sp UNC89_CAEEL 26.16 237 162 8 123 356 3239 3465 8.39E-09 61.2 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O70277 CHOYP_BRAFLDRAFT_79377.30.30 m.67042 sp TRIM3_RAT 26.923 130 89 2 73 196 614 743 8.39E-08 55.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; Q0IJ33 CHOYP_TM129.1.1 m.14371 sp TM129_XENTR 51.676 358 173 0 5 362 2 359 8.39E-146 419 TM129_XENTR reviewed E3 ubiquitin-protein ligase TM129 (EC 6.3.2.-) tmem129 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 362 protein ubiquitination [GO:0016567]; response to unfolded protein [GO:0006986] GO:0005789; GO:0006986; GO:0016021; GO:0016567; GO:0016874; GO:0046872 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF10272; Q4ZJM9 CHOYP_C1QT4.3.5 m.46406 sp C1QL4_MOUSE 34.127 126 75 3 215 332 110 235 8.39E-12 68.6 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q7KVW5 CHOYP_SK.1.1 m.45318 sp KCNN_DROME 36.01 411 246 6 46 442 468 875 8.39E-79 266 KCNN_DROME reviewed Small conductance calcium-activated potassium channel protein (Protein SK) (dSK) SK CG10706 Drosophila melanogaster (Fruit fly) 927 potassium ion transport [GO:0006813]; regulation of membrane potential in photoreceptor cell [GO:0016057] GO:0005516; GO:0005886; GO:0006813; GO:0009881; GO:0016021; GO:0016057; GO:0016286; GO:0043025 0 0 0 PF02888;PF07885;PF03530; Q7T163 CHOYP_LOC100640442.3.10 m.32542 sp KDIS_DANRE 35.621 306 180 10 432 726 4 303 8.39E-32 137 KDIS_DANRE reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) 1672 nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; regulation of protein kinase activity [GO:0045859] GO:0005770; GO:0007399; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0045859 0 0 0 PF00023;PF12796;PF07693; Q80T91 CHOYP_BRAFLDRAFT_224574.4.18 m.21938 sp MEG11_MOUSE 37.5 288 160 12 5 287 380 652 8.39E-41 154 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q9ESN6 CHOYP_BRAFLDRAFT_63298.3.6 m.32453 sp TRIM2_MOUSE 26.016 246 141 8 322 550 513 734 8.39E-10 65.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NYT6 CHOYP_ZN502.1.1 m.17759 sp ZN226_HUMAN 37.186 199 113 3 338 530 362 554 8.39E-34 140 ZN226_HUMAN reviewed Zinc finger protein 226 ZNF226 Homo sapiens (Human) 803 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096; Q9R0Q9 CHOYP_NEMVEDRAFT_V1G181729.1.1 m.23699 sp MPU1_MOUSE 32.751 229 149 1 93 316 17 245 8.39E-37 135 MPU1_MOUSE reviewed Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) (SL15) Mpdu1 Supl15h Mus musculus (Mouse) 247 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; oligosaccharide biosynthetic process [GO:0009312]; transport [GO:0006810] GO:0005739; GO:0005783; GO:0006488; GO:0006810; GO:0009312; GO:0016020; GO:0016021; GO:0070062 0 0 0 PF04193; Q9Y3A4 CHOYP_RRP7A.1.2 m.5480 sp RRP7A_HUMAN 41.063 207 115 4 21 223 22 225 8.39E-42 146 RRP7A_HUMAN reviewed Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14) RRP7A CGI-96 Homo sapiens (Human) 280 blastocyst formation [GO:0001825]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364] GO:0000028; GO:0000166; GO:0001825; GO:0005654; GO:0005737; GO:0006364; GO:0032545; GO:0034456; GO:0044822 0 0 0 PF12923; D2GXS7 CHOYP_BRAFLDRAFT_88218.1.8 m.8072 sp TRIM2_AILME 34.615 78 49 2 40 116 627 703 8.40E-06 46.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O14640 CHOYP_TSP_08621.1.1 m.26107 sp DVL1_HUMAN 68.75 32 10 0 159 190 664 695 8.40E-09 57.8 DVL1_HUMAN reviewed Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1) DVL1 Homo sapiens (Human) 695 "axon extension [GO:0048675]; axon guidance [GO:0007411]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; cochlea morphogenesis [GO:0090103]; collateral sprouting [GO:0048668]; convergent extension involved in neural plate elongation [GO:0022007]; cytoplasmic microtubule organization [GO:0031122]; dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of protein binding [GO:0032091]; negative regulation of protein kinase activity [GO:0006469]; neural tube development [GO:0021915]; neuromuscular junction development [GO:0007528]; neurotransmitter secretion [GO:0007269]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of Wnt signaling pathway [GO:0030177]; prepulse inhibition [GO:0060134]; protein localization to microtubule [GO:0035372]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; receptor clustering [GO:0043113]; regulation of cellular protein localization [GO:1903827]; regulation of neurotransmitter levels [GO:0001505]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; transcription from RNA polymerase II promoter [GO:0006366]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0001505; GO:0001934; GO:0005109; GO:0005829; GO:0005874; GO:0005886; GO:0006366; GO:0006469; GO:0007269; GO:0007411; GO:0007416; GO:0007528; GO:0010976; GO:0016023; GO:0019899; GO:0019901; GO:0021915; GO:0022007; GO:0030136; GO:0030177; GO:0030424; GO:0030425; GO:0030426; GO:0031122; GO:0031410; GO:0032091; GO:0032436; GO:0034504; GO:0035176; GO:0035372; GO:0035556; GO:0042802; GO:0043005; GO:0043025; GO:0043113; GO:0045202; GO:0045893; GO:0048668; GO:0048675; GO:0048813; GO:0050808; GO:0050821; GO:0060070; GO:0060071; GO:0060134; GO:0071340; GO:0090090; GO:0090103; GO:0090179; GO:0090263; GO:0098793; GO:1902474; GO:1903827; GO:1904886; GO:1990909 0 0 0 PF00610;PF02377;PF00778;PF12316;PF00595; O60140 CHOYP_LOC100368927.1.1 m.26897 sp YNS9_SCHPO 33.333 261 160 6 482 739 239 488 8.40E-39 154 YNS9_SCHPO reviewed Uncharacterized protein C18H10.09 SPBC18H10.09 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 495 0 GO:0005737; GO:0008270 0 0 0 PF05495; P27085 CHOYP_RS26.15.15 m.62868 sp RS26_OCTVU 74.775 111 27 1 4 114 11 120 8.40E-53 165 RS26_OCTVU reviewed 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) 127 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01283; P41241 CHOYP_PHUM_PHUM048780.1.1 m.24841 sp CSK_MOUSE 61.905 105 36 1 13 113 5 109 8.40E-40 140 CSK_MOUSE reviewed Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase MPK-2) (p50CSK) Csk Mus musculus (Mouse) 450 adaptive immune response [GO:0002250]; adherens junction organization [GO:0034332]; brain development [GO:0007420]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system development [GO:0007417]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of kinase activity [GO:0033673]; negative regulation of low-density lipoprotein particle clearance [GO:0010989]; negative regulation of phagocytosis [GO:0050765]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of MAP kinase activity [GO:0043406]; protein phosphorylation [GO:0006468]; regulation of cytokine production [GO:0001817]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of T cell activation [GO:0050863]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001817; GO:0002250; GO:0004713; GO:0004715; GO:0005102; GO:0005524; GO:0005737; GO:0005886; GO:0005911; GO:0006468; GO:0007169; GO:0007417; GO:0007420; GO:0008285; GO:0010989; GO:0016477; GO:0016740; GO:0030154; GO:0031234; GO:0032715; GO:0033673; GO:0034236; GO:0034332; GO:0035556; GO:0038083; GO:0042802; GO:0042997; GO:0043406; GO:0045087; GO:0045121; GO:0045779; GO:0046872; GO:0048709; GO:0050765; GO:0050863; GO:0060368; GO:0070062; GO:0070373; GO:0071375 0 0 0 PF07714;PF00017;PF00018; Q07230 CHOYP_ZN226.2.2 m.35078 sp ZSCA2_MOUSE 37.612 335 204 5 422 756 251 580 8.40E-68 241 ZSCA2_MOUSE reviewed Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29) (Zfp-29) Zscan2 Zfp-29 Zfp29 Mus musculus (Mouse) 614 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0007275; GO:0007283; GO:0030154; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6PFY8 CHOYP_LOC100378898.10.10 m.65489 sp TRI45_MOUSE 30.732 205 123 7 8 205 129 321 8.40E-13 73.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8N6T3 CHOYP_LOC100213772.1.1 m.22708 sp ARFG1_HUMAN 51.37 292 110 5 1 290 1 262 8.40E-96 292 ARFG1_HUMAN reviewed ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) ARFGAP1 ARF1GAP Homo sapiens (Human) 406 "ER to Golgi vesicle-mediated transport [GO:0006888]; IRE1-mediated unfolded protein response [GO:0036498]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005096; GO:0005829; GO:0006888; GO:0006890; GO:0015031; GO:0030100; GO:0036498; GO:0045202; GO:0046872 0 0 0 PF01412; Q8T880 CHOYP_LOC100377243.1.1 m.6500 sp AXP83_CIOIN 41.076 706 366 17 9 690 22 701 8.40E-148 451 AXP83_CIOIN reviewed Axonemal 84 kDa protein (Ci-AXP83.9) (p83.9) AXP83.9 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) 737 0 0 0 0 0 PF12366;PF15927; Q9Y6X6 CHOYP_MYO16.2.4 m.23233 sp MYO16_HUMAN 29.386 228 129 4 40 259 1009 1212 8.40E-23 109 MYO16_HUMAN reviewed Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16) MYO16 KIAA0865 MYO16B NYAP3 Homo sapiens (Human) 1858 cerebellum development [GO:0021549]; negative regulation of cell proliferation [GO:0008285]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134] GO:0003774; GO:0005524; GO:0005654; GO:0005737; GO:0005886; GO:0008285; GO:0016459; GO:0021549; GO:0048471; GO:0051015; GO:2000134 0 0 0 PF12796;PF00063; Q9Z2I2 CHOYP_FKBP12.1.1 m.32709 sp FKB1B_MOUSE 70.37 108 32 0 41 148 1 108 8.40E-56 173 FKB1B_MOUSE reviewed Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) Fkbp1b Mus musculus (Mouse) 108 chaperone-mediated protein folding [GO:0061077]; insulin secretion [GO:0030073]; negative regulation of heart rate [GO:0010459]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; negative regulation of protein phosphatase type 2B activity [GO:0032513]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; neuronal action potential propagation [GO:0019227]; positive regulation of axon regeneration [GO:0048680]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of sequestering of calcium ion [GO:0051284]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; release of sequestered calcium ion into cytosol [GO:0051209]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to redox state [GO:0051775]; response to vitamin E [GO:0033197]; smooth muscle contraction [GO:0006939]; T cell proliferation [GO:0042098] GO:0000413; GO:0002027; GO:0003755; GO:0005102; GO:0005528; GO:0005737; GO:0005829; GO:0006939; GO:0007204; GO:0009749; GO:0010459; GO:0010880; GO:0010881; GO:0014808; GO:0016020; GO:0016529; GO:0019227; GO:0019855; GO:0030018; GO:0030073; GO:0030551; GO:0032513; GO:0033017; GO:0033197; GO:0034704; GO:0042098; GO:0042542; GO:0044325; GO:0048680; GO:0051209; GO:0051280; GO:0051284; GO:0051480; GO:0051775; GO:0060314; GO:0060315; GO:0061077; GO:0061179 0 0 0 PF00254; D3ZAT9 CHOYP_LOC100377010.14.16 m.57915 sp FAXC_RAT 38.224 259 138 6 28 274 87 335 8.41E-53 180 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; O94759 CHOYP_LOC100898559.1.1 m.471 sp TRPM2_HUMAN 22.919 1610 908 55 65 1589 142 1503 8.41E-70 263 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; P12111 CHOYP_CO6A3.3.5 m.39796 sp CO6A3_HUMAN 23.281 1993 1267 74 757 2693 39 1825 8.41E-106 385 CO6A3_HUMAN reviewed Collagen alpha-3(VI) chain COL6A3 Homo sapiens (Human) 3177 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; extracellular matrix organization [GO:0030198]; muscle organ development [GO:0007517] GO:0004867; GO:0005576; GO:0005578; GO:0005589; GO:0005615; GO:0005788; GO:0007155; GO:0007517; GO:0030198; GO:0030574; GO:0031012; GO:0042383; GO:0070062; GO:1903561 0 0 0 PF01391;PF00014;PF00092; P18503 CHOYP_BRAFLDRAFT_76550.20.21 m.65941 sp CAS4_EPHMU 33.071 127 59 4 92 212 207 313 8.41E-08 56.2 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; P95896 CHOYP_BRAFLDRAFT_94568.1.2 m.32840 sp AMID_SULSO 45.951 494 258 4 20 505 9 501 8.41E-146 431 AMID_SULSO reviewed Amidase (EC 3.5.1.4) SSO2122 C02016 C02_017 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 504 0 GO:0004040; GO:0016884 0 0 0 PF01425; Q3ZBP3 CHOYP_LOC100744046.1.2 m.2205 sp RBMS1_BOVIN 70.857 175 45 2 21 189 57 231 8.41E-85 262 RBMS1_BOVIN reviewed "RNA-binding motif, single-stranded-interacting protein 1" RBMS1 Bos taurus (Bovine) 403 DNA replication [GO:0006260] GO:0000166; GO:0003677; GO:0005634; GO:0006260; GO:0044822 0 0 0 PF00076; Q56UN5 CHOYP_LOC100374274.3.3 m.34862 sp M3K19_HUMAN 64.388 278 96 2 2174 2450 1051 1326 8.41E-112 394 M3K19_HUMAN reviewed "Mitogen-activated protein kinase kinase kinase 19 (EC 2.7.11.1) (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4)" MAP3K19 RCK YSK4 Homo sapiens (Human) 1328 actin cytoskeleton organization [GO:0030036] GO:0004702; GO:0005524; GO:0005737; GO:0030036 0 0 0 PF00069; Q5VT06 CHOYP_CEP350.1.1 m.4119 sp CE350_HUMAN 36.928 677 307 23 1399 2054 1570 2147 8.41E-74 280 CE350_HUMAN reviewed Centrosome-associated protein 350 (Cep350) (Centrosome-associated protein of 350 kDa) CEP350 CAP350 KIAA0480 GM133 Homo sapiens (Human) 3117 microtubule anchoring [GO:0034453] GO:0005654; GO:0005737; GO:0005813; GO:0005819; GO:0016020; GO:0034453 0 0 0 PF01302; Q9CQP3 CHOYP_LOC100000646.1.2 m.15274 sp CHCH5_MOUSE 25.843 89 66 0 11 99 10 98 8.41E-13 62 CHCH5_MOUSE reviewed Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 Chchd5 Mus musculus (Mouse) 110 aerobic respiration [GO:0009060] GO:0005758; GO:0009060 0 0 0 PF16860; O46658 CHOYP_CP2BA.1.1 m.38084 sp CP2DP_PIG 29.194 459 305 10 39 486 51 500 8.42E-61 210 CP2DP_PIG reviewed Vitamin D(3) 25-hydroxylase (EC 1.14.15.15) (CYPIID25) (Cytochrome P450 2D25) CYP2D25 Sus scrofa (Pig) 500 arachidonic acid metabolic process [GO:0019369] GO:0005506; GO:0005789; GO:0008392; GO:0008395; GO:0016712; GO:0019369; GO:0020037; GO:0031090 0 0 0 PF00067; P35601 CHOYP_RFC1.2.3 m.27524 sp RFC1_MOUSE 68.932 103 28 1 18 116 355 457 8.42E-38 137 RFC1_MOUSE reviewed Replication factor C subunit 1 (A1-P145) (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (Differentiation-specific element-binding protein) (ISRE-binding protein) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit) Rfc1 Ibf-1 Recc1 Mus musculus (Mouse) 1131 "DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003689; GO:0005524; GO:0005634; GO:0005654; GO:0005663; GO:0006260; GO:0006281; GO:0006351; GO:0006355; GO:0070062 0 0 0 PF00004;PF00533;PF08519; Q2KI24 CHOYP_RARB.3.3 m.54033 sp MTHSD_BOVIN 62.151 251 95 0 23 273 7 257 8.42E-114 345 MTHSD_BOVIN reviewed Methenyltetrahydrofolate synthase domain-containing protein MTHFSD Bos taurus (Bovine) 380 0 GO:0000166; GO:0044822 0 0 0 PF01812;PF00076; Q5UPF8 CHOYP_TVAG_249230.1.1 m.66266 sp YL088_MIMIV 24.779 339 197 7 106 428 83 379 8.42E-11 67.8 YL088_MIMIV reviewed Putative ankyrin repeat protein L88 MIMI_L88 Acanthamoeba polyphaga mimivirus (APMV) 879 0 0 0 0 0 PF12796; Q6Q899 CHOYP_DDX58.2.9 m.2704 sp DDX58_MOUSE 32.618 466 275 14 365 814 212 654 8.42E-54 204 DDX58_MOUSE reviewed Probable ATP-dependent RNA helicase DDX58 (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I) Ddx58 Mus musculus (Mouse) 926 detection of virus [GO:0009597]; innate immune response [GO:0045087]; negative regulation of type I interferon production [GO:0032480]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell migration [GO:0030334]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RIG-I signaling pathway [GO:0039529] GO:0002230; GO:0003690; GO:0003725; GO:0003727; GO:0004386; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0008270; GO:0009597; GO:0009615; GO:0010628; GO:0015629; GO:0030334; GO:0032480; GO:0032587; GO:0032725; GO:0032727; GO:0032728; GO:0032755; GO:0032757; GO:0039529; GO:0042802; GO:0042993; GO:0043330; GO:0045087; GO:0045944 0 0 0 PF16739;PF00271;PF04851;PF11648; Q8K0U4 CHOYP_HSPA12A.21.27 m.57005 sp HS12A_MOUSE 28.656 677 395 18 1614 2214 9 673 8.42E-71 256 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8N448 CHOYP_LNX2.1.1 m.32075 sp LNX2_HUMAN 40.385 676 317 13 31 623 18 690 8.42E-155 464 LNX2_HUMAN reviewed Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1) LNX2 PDZRN1 Homo sapiens (Human) 690 protein homooligomerization [GO:0051260] GO:0008270; GO:0051260 0 0 0 PF00595; Q8WWB3 CHOYP_BRAFLDRAFT_120058.1.1 m.9895 sp DYDC1_HUMAN 52 75 36 0 1 75 1 75 8.42E-20 84.7 DYDC1_HUMAN reviewed DPY30 domain-containing protein 1 DYDC1 DPY30D1 RSD-9 RSD9 Homo sapiens (Human) 177 chromatin silencing at telomere [GO:0006348]; histone H3-K4 methylation [GO:0051568] GO:0000781; GO:0006348; GO:0048188; GO:0051568 0 0 0 PF05186; Q92890 CHOYP_UFD1L.1.1 m.43606 sp UFD1_HUMAN 63.918 291 95 4 15 298 19 306 8.42E-128 369 UFD1_HUMAN reviewed Ubiquitin fusion degradation protein 1 homolog (UB fusion protein 1) UFD1L Homo sapiens (Human) 307 "ER-associated misfolded protein catabolic process [GO:0071712]; error-free translesion synthesis [GO:0070987]; retrograde protein transport, ER to cytosol [GO:0030970]; skeletal system development [GO:0001501]; ubiquitin-dependent protein catabolic process [GO:0006511]" GO:0001501; GO:0004843; GO:0005634; GO:0005654; GO:0005829; GO:0006511; GO:0030970; GO:0034098; GO:0036501; GO:0070987; GO:0071712 PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. 0 0 PF03152; Q95SX7 CHOYP_LOC100561123.28.28 m.64559 sp RTBS_DROME 32.444 225 150 2 243 466 436 659 8.42E-25 111 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q99M80 CHOYP_PTPRA.13.22 m.50994 sp PTPRT_MOUSE 30.548 694 434 17 446 1099 768 1453 8.42E-83 299 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9H0U6 CHOYP_LOC591926.1.1 m.27235 sp RM18_HUMAN 36.145 166 104 1 17 182 13 176 8.42E-31 114 RM18_HUMAN reviewed "39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18)" MRPL18 HSPC071 Homo sapiens (Human) 180 mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; rRNA import into mitochondrion [GO:0035928]; translation [GO:0006412] GO:0003735; GO:0005615; GO:0005739; GO:0005743; GO:0005761; GO:0006412; GO:0008097; GO:0035928; GO:0070125; GO:0070126 0 0 0 PF00861; Q9R1R2 CHOYP_BRAFLDRAFT_87317.1.1 m.42066 sp TRIM3_MOUSE 26.016 123 87 3 22 141 622 743 8.42E-07 54.3 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; U3JAG9 CHOYP_AZI1.1.1 m.57111 sp CP131_DANRE 56.875 480 187 4 547 1013 641 1113 8.42E-157 495 CP131_DANRE reviewed Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) cep131 azi1 Danio rerio (Zebrafish) (Brachydanio rerio) 1113 cell differentiation [GO:0030154]; cilium morphogenesis [GO:0060271]; epithelial cilium movement involved in determination of left/right asymmetry [GO:0060287]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium morphogenesis [GO:0035735]; Kupffer's vesicle development [GO:0070121]; melanosome transport [GO:0032402]; negative regulation of intracellular protein transport [GO:0090317]; regulation of centrosome duplication [GO:0010824]; sensory perception of light stimulus [GO:0050953] GO:0000775; GO:0005929; GO:0010824; GO:0030154; GO:0032402; GO:0034451; GO:0035721; GO:0035735; GO:0050953; GO:0060271; GO:0060287; GO:0070121; GO:0090317 0 0 0 0 D3YXG0 CHOYP_HSPG2.2.4 m.21779 sp HMCN1_MOUSE 26.289 1590 946 70 314 1836 480 1910 8.43E-89 328 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O15527 CHOYP_LOC100378570.1.1 m.25501 sp OGG1_HUMAN 43.052 367 167 4 7 370 18 345 8.43E-106 319 OGG1_HUMAN reviewed N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] OGG1 MMH MUTM OGH1 Homo sapiens (Human) 345 "acute inflammatory response [GO:0002526]; aging [GO:0007568]; base-excision repair [GO:0006284]; cellular response to cadmium ion [GO:0071276]; cellular response to DNA damage stimulus [GO:0006974]; depurination [GO:0045007]; depyrimidination [GO:0045008]; negative regulation of apoptotic process [GO:0043066]; negative regulation of double-strand break repair via single-strand annealing [GO:1901291]; nucleotide-excision repair, DNA incision [GO:0033683]; regulation of protein import into nucleus, translocation [GO:0033158]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to light stimulus [GO:0009416]; response to oxidative stress [GO:0006979]; response to radiation [GO:0009314]" GO:0002526; GO:0003684; GO:0004519; GO:0005634; GO:0005654; GO:0005739; GO:0006284; GO:0006355; GO:0006974; GO:0006979; GO:0007568; GO:0008534; GO:0009314; GO:0009416; GO:0016363; GO:0016607; GO:0032355; GO:0032357; GO:0033158; GO:0033683; GO:0034039; GO:0042493; GO:0043066; GO:0043234; GO:0045007; GO:0045008; GO:0045471; GO:0051593; GO:0071276; GO:1901291 0 0 cd00056; PF00730;PF07934; P11678 CHOYP_BRAFLDRAFT_125550.1.5 m.9080 sp PERE_HUMAN 32.7 737 426 20 1 691 1 713 8.43E-108 345 PERE_HUMAN reviewed Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain] EPX EPER EPO EPP Homo sapiens (Human) 715 defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979] GO:0002215; GO:0004601; GO:0006979; GO:0020037; GO:0032693; GO:0032714; GO:0032753; GO:0042744; GO:0046872; GO:0070062; GO:0072677 0 0 0 PF03098; P23727 CHOYP_LOC100372481.1.1 m.21010 sp P85A_BOVIN 38.599 614 329 15 346 933 128 719 8.43E-108 353 P85A_BOVIN reviewed Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) PIK3R1 Bos taurus (Bovine) 724 B cell differentiation [GO:0030183]; cellular glucose homeostasis [GO:0001678]; cellular response to insulin stimulus [GO:0032869]; cellular response to UV [GO:0034644]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; growth hormone receptor signaling pathway [GO:0060396]; insulin-like growth factor receptor signaling pathway [GO:0048009]; insulin receptor signaling pathway [GO:0008286]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of osteoclast differentiation [GO:0045671]; NFAT protein import into nucleus [GO:0051531]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphatidylinositol phosphorylation [GO:0046854]; positive regulation of cell migration [GO:0030335]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of RNA splicing [GO:0033120]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol 3-kinase activity [GO:0043551]; regulation of stress fiber assembly [GO:0051492]; response to endoplasmic reticulum stress [GO:0034976] GO:0001678; GO:0001953; GO:0005068; GO:0005158; GO:0005159; GO:0005634; GO:0005801; GO:0005829; GO:0005911; GO:0005942; GO:0005943; GO:0006468; GO:0008286; GO:0008625; GO:0008630; GO:0014065; GO:0030183; GO:0030335; GO:0032760; GO:0032869; GO:0033120; GO:0034644; GO:0034976; GO:0035014; GO:0042993; GO:0043066; GO:0043125; GO:0043548; GO:0043551; GO:0043560; GO:0045671; GO:0045944; GO:0046326; GO:0046854; GO:0046935; GO:0048009; GO:0050821; GO:0051492; GO:0051531; GO:0060396; GO:0090004; GO:1900103; GO:1990578; GO:2001275 0 0 0 PF16454;PF00620;PF00017; P24386 CHOYP_BRAFLDRAFT_123298.1.1 m.484 sp RAE1_HUMAN 36.842 190 110 4 3 186 430 615 8.43E-31 124 RAE1_HUMAN reviewed Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein) CHM REP1 TCD Homo sapiens (Human) 653 protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; regulation of apoptotic process [GO:0042981]; small GTPase mediated signal transduction [GO:0007264]; visual perception [GO:0007601] GO:0004663; GO:0005092; GO:0005096; GO:0005829; GO:0005968; GO:0006612; GO:0007264; GO:0007601; GO:0016491; GO:0017137; GO:0018344; GO:0042981 0 0 0 PF00996; Q4R632 CHOYP_LOC580601.4.5 m.50044 sp CBPC2_MACFA 48.673 452 214 4 120 571 228 661 8.43E-146 456 CBPC2_MACFA reviewed Cytosolic carboxypeptidase 2 (EC 3.4.17.-) (ATP/GTP-binding protein-like 2) AGBL2 CCP2 QtsA-19251 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 840 protein side chain deglutamylation [GO:0035610] GO:0004181; GO:0005814; GO:0005829; GO:0008270; GO:0035610; GO:0036064 0 0 0 PF00246; Q503Q1 CHOYP_LOC100901772.2.2 m.62500 sp MIEAP_DANRE 24.883 213 137 9 514 720 250 445 8.43E-09 62.4 MIEAP_DANRE reviewed Mitochondria-eating protein (Spermatogenesis-associated protein 18) spata18 mieap si:ch73-16a12.2 zgc:110352 Danio rerio (Zebrafish) (Brachydanio rerio) 490 cellular response to DNA damage stimulus [GO:0006974]; mitochondrial protein catabolic process [GO:0035694]; mitophagy by induced vacuole formation [GO:0035695] GO:0005737; GO:0005741; GO:0006974; GO:0035694; GO:0035695; GO:0043231 0 0 0 PF16026; Q7Z2W7 CHOYP_NEMVEDRAFT_V1G248535.2.2 m.58351 sp TRPM8_HUMAN 27.347 490 292 15 569 1027 564 1020 8.43E-41 167 TRPM8_HUMAN reviewed Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) TRPM8 LTRPC6 TRPP8 Homo sapiens (Human) 1104 calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955] GO:0005262; GO:0005789; GO:0005886; GO:0006874; GO:0009409; GO:0009897; GO:0016021; GO:0016048; GO:0045121; GO:0050955; GO:0051289; GO:0070207; GO:0070588 0 0 0 PF00520; Q8IWW6 CHOYP_ARHGAP12B.2.2 m.51676 sp RHG12_HUMAN 31.688 871 463 30 30 815 21 844 8.43E-99 329 RHG12_HUMAN reviewed Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12) ARHGAP12 Homo sapiens (Human) 846 morphogenesis of an epithelial sheet [GO:0002011]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165] GO:0002011; GO:0005096; GO:0005829; GO:0007165; GO:0051056 0 0 0 PF00169;PF00620;PF14604; Q91YX5 CHOYP_BRAFLDRAFT_77131.1.1 m.36892 sp LGAT1_MOUSE 39.867 301 170 3 14 305 24 322 8.43E-75 239 LGAT1_MOUSE reviewed Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (EC 2.3.1.-) Lpgat1 Fam34a Mus musculus (Mouse) 370 phospholipid biosynthetic process [GO:0008654] GO:0005737; GO:0005789; GO:0008654; GO:0016020; GO:0016021; GO:0016746 0 0 0 PF16076;PF01553; Q99NH0 CHOYP_LOC100641396.12.27 m.37923 sp ANR17_MOUSE 34.908 487 297 14 219 687 218 702 8.43E-56 210 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; Q9NZJ4 CHOYP_BRAFLDRAFT_67666.1.6 m.13315 sp SACS_HUMAN 29.417 1132 688 36 2 1051 2365 3467 8.43E-121 413 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; O14874 CHOYP_BCKD.2.2 m.60038 sp BCKD_HUMAN 54.848 361 155 2 33 393 38 390 8.44E-142 418 BCKD_HUMAN reviewed "[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial (EC 2.7.11.4) (Branched-chain alpha-ketoacid dehydrogenase kinase) (BCKD-kinase) (BCKDHKIN)" BCKDK Homo sapiens (Human) 412 branched-chain amino acid catabolic process [GO:0009083]; cellular amino acid catabolic process [GO:0009063]; phosphorylation [GO:0016310] GO:0004674; GO:0005524; GO:0005739; GO:0005759; GO:0005947; GO:0009063; GO:0009083; GO:0016301; GO:0016310; GO:0047323 0 0 0 PF10436;PF02518; P49013 CHOYP_LOC100634060.25.37 m.51172 sp FBP3_STRPU 53.211 218 100 1 359 576 175 390 8.44E-70 238 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P55006 CHOYP_RDH7.1.2 m.26998 sp RDH7_RAT 42.434 304 168 5 3 305 1 298 8.44E-68 218 RDH7_RAT reviewed Retinol dehydrogenase 7 (EC 1.1.1.105) (Retinol dehydrogenase type III) (RODH III) Rdh7 Rattus norvegicus (Rat) 317 retinol metabolic process [GO:0042572] GO:0004745; GO:0005783; GO:0042572 PATHWAY: Cofactor metabolism; retinol metabolism. 0 0 PF00106; Q04666 CHOYP_LOC101065156.1.1 m.31486 sp HES1_RAT 43.802 121 58 3 19 136 30 143 8.44E-21 93.6 HES1_RAT reviewed Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy-like protein) (RHL) Hes1 Hes-1 Hl Rattus norvegicus (Rat) 281 "cellular response to fatty acid [GO:0071398]; cellular response to interleukin-1 [GO:0071347]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to tumor necrosis factor [GO:0071356]; forebrain radial glial cell differentiation [GO:0021861]; hair cell differentiation [GO:0035315]; negative regulation of calcium ion import [GO:0090281]; negative regulation of forebrain neuron differentiation [GO:2000978]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuronal stem cell population maintenance [GO:0097150]; neuron differentiation [GO:0030182]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of DNA binding [GO:0043388]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; protein complex assembly [GO:0006461]; regulation of protein heterodimerization activity [GO:0043497]; response to alkaloid [GO:0043279]; response to organic cyclic compound [GO:0014070]; response to thyroid hormone [GO:0097066]; STAT protein import into nucleus [GO:0007262]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000785; GO:0001078; GO:0003677; GO:0003682; GO:0005634; GO:0005654; GO:0006351; GO:0006461; GO:0007262; GO:0008134; GO:0008432; GO:0010628; GO:0010629; GO:0010977; GO:0014070; GO:0016363; GO:0021861; GO:0030182; GO:0032403; GO:0035315; GO:0042517; GO:0042803; GO:0043279; GO:0043388; GO:0043497; GO:0043565; GO:0045687; GO:0045892; GO:0046427; GO:0048711; GO:0048715; GO:0050768; GO:0060253; GO:0070888; GO:0071347; GO:0071356; GO:0071398; GO:0071820; GO:0090281; GO:0097066; GO:0097150; GO:1903026; GO:1990090; GO:2000974; GO:2000978 0 0 0 PF07527;PF00010; Q460N5 CHOYP_LOC100374497.2.2 m.60675 sp PAR14_HUMAN 28.333 180 121 2 675 852 1027 1200 8.44E-18 93.2 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q9NUV9 CHOYP_LOC100005182.1.1 m.53007 sp GIMA4_HUMAN 40.892 269 153 2 138 406 7 269 8.44E-66 219 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; A0A0R4IBK5 CHOYP_contig_045460 m.52870 sp R213A_DANRE 18.793 1027 645 39 72 1030 221 1126 8.45E-06 54.3 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O14867 CHOYP_LOC100575377.9.10 m.49255 sp BACH1_HUMAN 27.731 119 86 0 18 136 9 127 8.45E-10 65.5 BACH1_HUMAN reviewed Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) 736 "DNA repair [GO:0006281]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]" GO:0000083; GO:0000117; GO:0000122; GO:0000980; GO:0001078; GO:0001205; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006281; GO:0006355; GO:0016567; GO:0020037; GO:0031463; GO:0061418 0 0 0 PF00651;PF03131; O61231 CHOYP_LOC100304526.1.1 m.22366 sp RL10_DROME 73.333 105 27 1 1 105 87 190 8.45E-50 160 RL10_DROME reviewed 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0043025; GO:0051297; GO:0051298 0 0 cd01433; PF00252; O61967 CHOYP_LOC100888877.1.1 m.49623 sp LAP1_CAEEL 35.319 235 147 3 46 278 39 270 8.45E-27 114 LAP1_CAEEL reviewed Protein lap1 (Lethal protein 413) let-413 F26D11.11 Caenorhabditis elegans 699 actin filament-based process [GO:0030029]; cell adhesion [GO:0007155]; cell-cell junction assembly [GO:0007043]; embryo development ending in birth or egg hatching [GO:0009792]; embryonic digestive tract morphogenesis [GO:0048557]; establishment or maintenance of cell polarity [GO:0007163]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; protein transport [GO:0015031]; regulation of intermediate filament polymerization or depolymerization [GO:0045108] GO:0005912; GO:0007043; GO:0007155; GO:0007163; GO:0009792; GO:0015031; GO:0016323; GO:0030029; GO:0045108; GO:0045199; GO:0048557 0 0 0 PF13855;PF00595; O70451 CHOYP_AAEL_AAEL000417.1.1 m.51079 sp MOT2_MOUSE 36.564 227 135 3 25 246 12 234 8.45E-38 150 MOT2_MOUSE reviewed Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7) Slc16a7 Mct2 Mus musculus (Mouse) 484 lactate transmembrane transport [GO:0035873]; plasma membrane lactate transport [GO:0035879]; pyruvate transmembrane transport [GO:1901475] GO:0005737; GO:0005887; GO:0008028; GO:0015129; GO:0015293; GO:0035873; GO:0035879; GO:0050833; GO:1901475 0 0 cd06174; PF07690; P27867 CHOYP_LOC100370478.1.2 m.10789 sp DHSO_RAT 54.815 135 58 1 67 201 219 350 8.45E-47 160 DHSO_RAT reviewed Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) Sord Sdh1 Rattus norvegicus (Rat) 357 fructose biosynthetic process [GO:0046370]; L-xylitol catabolic process [GO:0051160]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to hormone [GO:0009725]; response to nutrient levels [GO:0031667]; response to osmotic stress [GO:0006970]; sorbitol catabolic process [GO:0006062]; sperm motility [GO:0030317] GO:0003939; GO:0006062; GO:0006970; GO:0008270; GO:0009725; GO:0030317; GO:0031514; GO:0031667; GO:0031966; GO:0042493; GO:0042802; GO:0046370; GO:0046526; GO:0046686; GO:0046688; GO:0051160; GO:0051287; GO:0070062 0 0 0 PF08240;PF00107; P41112 CHOYP_ACTA.2.2 m.43370 sp ACT1_PODCA 89.714 175 17 1 1 175 1 174 8.45E-113 328 ACT1_PODCA reviewed Actin-1/2 ACTIA; ACTIIB Podocoryna carnea (Jellyfish) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P62084 CHOYP_BRAFLDRAFT_279789.1.3 m.37212 sp RS7_DANRE 77.778 72 15 1 1 71 1 72 8.45E-32 113 RS7_DANRE reviewed 40S ribosomal protein S7 rps7 zgc:73216 Danio rerio (Zebrafish) (Brachydanio rerio) 194 chordate embryonic development [GO:0043009]; hemopoiesis [GO:0030097]; regulation of cell cycle [GO:0051726]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; translation [GO:0006412] GO:0003735; GO:0006364; GO:0006412; GO:0022627; GO:0030097; GO:0030686; GO:0032040; GO:0042274; GO:0043009; GO:0051726 0 0 0 PF01251; Q14416 CHOYP_GRM1.2.2 m.65835 sp GRM2_HUMAN 23.791 786 516 29 51 796 34 776 8.45E-40 162 GRM2_HUMAN reviewed Metabotropic glutamate receptor 2 (mGluR2) GRM2 GPRC1B MGLUR2 Homo sapiens (Human) 872 "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [GO:0007196]; chemical synaptic transmission [GO:0007268]; glutamate secretion [GO:0014047]; negative regulation of adenylate cyclase activity [GO:0007194]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0001641; GO:0004930; GO:0005246; GO:0005622; GO:0005886; GO:0005887; GO:0007194; GO:0007196; GO:0007268; GO:0008066; GO:0014047; GO:0030054; GO:0030424; GO:0030425; GO:0042734; GO:0051966 0 0 0 PF00003;PF01094;PF07562; Q5SUD9 CHOYP_LOC100559268.1.1 m.8893 sp BBS12_MOUSE 25.175 429 268 11 419 798 268 692 8.45E-19 95.1 BBS12_MOUSE reviewed Bardet-Biedl syndrome 12 protein homolog Bbs12 Gm1805 Mus musculus (Mouse) 708 chaperone-mediated protein complex assembly [GO:0051131]; eating behavior [GO:0042755]; intraciliary transport [GO:0042073]; negative regulation of fat cell differentiation [GO:0045599]; photoreceptor cell maintenance [GO:0045494] GO:0005524; GO:0005929; GO:0042073; GO:0042755; GO:0045494; GO:0045599; GO:0051131 0 0 0 PF00118; Q6IRN2 CHOYP_HOW.4.5 m.43659 sp QKIB_XENLA 48.679 265 95 5 1 264 109 333 8.45E-71 224 QKIB_XENLA reviewed Protein quaking-B qki-b Xenopus laevis (African clawed frog) 342 cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism development [GO:0007275]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380] GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0006417; GO:0007275; GO:0008380; GO:0030154; GO:0051028 0 0 0 PF00013;PF16551;PF16544; Q86FP7 CHOYP_RS23.7.9 m.50691 sp RS23_DERVA 88.372 129 14 1 1 128 15 143 8.45E-80 234 RS23_DERVA reviewed 40S ribosomal protein S23 RpS23 Dermacentor variabilis (American dog tick) 143 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935 0 0 cd03367; PF00164; Q8R0M8 CHOYP_LOC409131.2.2 m.65282 sp MOT5_MOUSE 24.299 535 362 8 24 557 5 497 8.45E-45 169 MOT5_MOUSE reviewed Monocarboxylate transporter 5 (MCT 5) Slc16a4 Mct5 Mus musculus (Mouse) 500 plasma membrane lactate transport [GO:0035879] GO:0005887; GO:0015129; GO:0015293; GO:0035879 0 0 cd06174; PF07690; Q9JHB3 CHOYP_LOC100533225.2.2 m.59326 sp TIMP4_MOUSE 28.155 206 122 8 19 216 29 216 8.45E-24 99 TIMP4_MOUSE reviewed Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4) Timp4 Mus musculus (Mouse) 224 central nervous system development [GO:0007417]; negative regulation of catalytic activity [GO:0043086]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; Notch signaling pathway [GO:0007219]; ovulation cycle [GO:0042698]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to organic substance [GO:0010033]; response to peptide hormone [GO:0043434] GO:0002020; GO:0005578; GO:0005615; GO:0007219; GO:0007417; GO:0008191; GO:0010033; GO:0030017; GO:0032496; GO:0034097; GO:0042493; GO:0042698; GO:0043086; GO:0043434; GO:0046872; GO:0051045 0 0 0 PF00965; P16157 CHOYP_LOC755521.17.28 m.47276 sp ANK1_HUMAN 33.333 486 324 0 6 491 289 774 8.46E-82 280 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P16157 CHOYP_TVAG_123950.13.31 m.33795 sp ANK1_HUMAN 32.401 429 279 3 1 426 80 500 8.46E-65 228 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q0VD31 CHOYP_PHUM_PHUM257210.2.3 m.60254 sp FBXL4_BOVIN 26.374 182 100 6 21 169 47 227 8.46E-12 68.9 FBXL4_BOVIN reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) FBXL4 Bos taurus (Bovine) 621 0 GO:0005634; GO:0005758 0 0 0 PF00646; Q28G67 CHOYP_F206A.1.1 m.49540 sp F206A_XENTR 52.83 159 74 1 25 182 10 168 8.46E-54 172 F206A_XENTR reviewed Protein Simiate (Protein FAM206A) fam206a TGas009a04.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 183 0 GO:0016607 0 0 0 0 Q8JG33 CHOYP_WFDC1.1.1 m.29739 sp WFDC1_CHICK 38.655 119 70 2 69 187 68 183 8.46E-26 103 WFDC1_CHICK reviewed WAP four-disulfide core domain protein 1 (Protein ps20) WFDC1 PS20 Gallus gallus (Chicken) 222 negative regulation of inflammatory response [GO:0050728]; negative regulation of wound healing [GO:0061045]; regulation of cell growth [GO:0001558] GO:0001558; GO:0004867; GO:0005615; GO:0050728; GO:0061045 0 0 0 PF00095; Q8NDA2 CHOYP_PHUM_PHUM068980.3.5 m.56541 sp HMCN2_HUMAN 23.272 434 263 20 105 495 2248 2654 8.46E-15 82.4 HMCN2_HUMAN reviewed Hemicentin-2 HMCN2 Homo sapiens (Human) 5059 response to stimulus [GO:0050896] GO:0005509; GO:0005578; GO:0050896 0 0 0 PF12662;PF07645;PF07474;PF07679; Q8R4D5 CHOYP_TRPM4.2.2 m.50988 sp TRPM8_MOUSE 20.061 977 602 33 35 936 142 1014 8.46E-24 112 TRPM8_MOUSE reviewed Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8) Trpm8 Ltrpc6 Trpp8 Mus musculus (Mouse) 1104 calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; response to temperature stimulus [GO:0009266]; thermoception [GO:0050955] GO:0005216; GO:0005262; GO:0005886; GO:0006816; GO:0006874; GO:0009266; GO:0009409; GO:0009897; GO:0016020; GO:0016021; GO:0016048; GO:0042803; GO:0045121; GO:0050955; GO:0051289; GO:0070207 0 0 0 0 Q9CRB6 CHOYP_BRAFLDRAFT_114379.1.1 m.57424 sp TPPP3_MOUSE 41.176 187 85 9 1 176 1 173 8.46E-23 92.4 TPPP3_MOUSE reviewed Tubulin polymerization-promoting protein family member 3 Tppp3 Mus musculus (Mouse) 176 microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785] GO:0001578; GO:0005737; GO:0005874; GO:0015631; GO:0046785; GO:0070062 0 0 0 PF05517; A1L2T6 CHOYP_LOC100555739.1.1 m.15949 sp ZCHC7_XENLA 27.873 409 255 13 5 392 18 407 8.47E-33 136 ZCHC7_XENLA reviewed Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) zcchc7 Xenopus laevis (African clawed frog) 563 0 GO:0003676; GO:0005730; GO:0008270 0 0 0 PF00098; A4IF63 CHOYP_BRAFLDRAFT_77992.3.3 m.42640 sp TRIM2_BOVIN 32 125 77 4 429 548 622 743 8.47E-11 68.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; E1BD59 CHOYP_BRAFLDRAFT_88223.9.22 m.34933 sp TRI56_BOVIN 24.478 527 325 14 3 467 9 524 8.47E-34 139 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; F6QEU4 CHOYP_LOC100368020.13.29 m.25696 sp LIN41_XENTR 23.182 220 121 6 7 201 141 337 8.47E-08 55.8 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; G5E8K5 CHOYP_TVAG_033850.1.1 m.51963 sp ANK3_MOUSE 30 410 265 6 97 505 285 673 8.47E-35 144 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P12890 CHOYP_PAM.1.1 m.27519 sp AMDB_XENLA 36.804 826 440 23 34 816 62 848 8.47E-170 516 AMDB_XENLA reviewed Peptidyl-glycine alpha-amidating monooxygenase B (PAM-B) (Peptide C-terminal alpha-amidating enzyme II) (AE-II) (Peptidyl-glycine alpha-amidating monooxygenase II) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase B (PHM-B) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase B (EC 4.3.2.5) (Peptidylamidoglycolate lyase-B) (PAL-B)] pam-b Xenopus laevis (African clawed frog) 875 peptide metabolic process [GO:0006518] GO:0004504; GO:0004598; GO:0005507; GO:0006518; GO:0016021; GO:0030658 0 0 0 PF03712;PF01082;PF01436; Q15650 CHOYP_LOC100367001.1.1 m.55663 sp TRIP4_HUMAN 46.528 576 252 13 5 529 4 574 8.47E-160 469 TRIP4_HUMAN reviewed Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4) TRIP4 Homo sapiens (Human) 581 "intracellular estrogen receptor signaling pathway [GO:0030520]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; toxin transport [GO:1901998]; transcription, DNA-templated [GO:0006351]" GO:0002020; GO:0003713; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005815; GO:0005829; GO:0006351; GO:0006355; GO:0008270; GO:0016922; GO:0030331; GO:0030520; GO:0031594; GO:0035035; GO:0044389; GO:0045893; GO:1901998 0 0 0 PF04266;PF06221; Q17103 CHOYP_MYC.2.2 m.47339 sp MYC_ASTRU 33.411 431 182 16 2 367 13 403 8.47E-41 151 MYC_ASTRU reviewed Myc protein (c-myc) (Fragment) MYC Asterias rubens (Common European starfish) (Asterias vulgaris) 407 "transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351 0 0 0 PF00010;PF01056; Q24157 CHOYP_DPSE_GA18536.2.2 m.47561 sp BRN_DROME 35.741 263 146 6 156 407 75 325 8.47E-44 158 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q96EQ0 CHOYP_LOC100373484.1.1 m.8540 sp SGTB_HUMAN 45.779 308 149 6 1 307 1 291 8.47E-83 256 SGTB_HUMAN reviewed Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) SGTB SGT2 Homo sapiens (Human) 304 0 0 0 0 0 PF16546;PF00515;PF13414; Q9BXX0 CHOYP_MYH9.3.3 m.42746 sp EMIL2_HUMAN 32.867 143 81 4 290 419 907 1047 8.47E-09 61.2 EMIL2_HUMAN reviewed EMILIN-2 (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10) EMILIN2 Homo sapiens (Human) 1053 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0030023; GO:0031012 0 0 0 PF00386;PF07546; Q9GZ71 CHOYP_TPM.18.19 m.66023 sp TPM_HALDV 68.072 166 53 0 1 166 1 166 8.47E-68 211 TPM_HALDV reviewed Tropomyosin 0 Haliotis diversicolor (Abalone) (Sulculus diversicolor) 284 0 0 0 0 0 PF00261; Q9R1R2 CHOYP_BRAFLDRAFT_89819.4.4 m.61882 sp TRIM3_MOUSE 27.485 171 116 4 312 479 552 717 8.47E-06 53.5 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9UL36 CHOYP_ZNF236.1.1 m.62715 sp ZN236_HUMAN 64.286 112 37 2 131 241 38 147 8.47E-38 145 ZN236_HUMAN reviewed Zinc finger protein 236 ZNF236 Homo sapiens (Human) 1845 "cellular response to glucose stimulus [GO:0071333]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872; GO:0071333 0 0 0 PF00096;PF13912; A6QNP3 CHOYP_LOC100373497.1.1 m.66598 sp PPR3B_BOVIN 44.67 197 102 3 118 311 45 237 8.48E-47 163 PPR3B_BOVIN reviewed Protein phosphatase 1 regulatory subunit 3B PPP1R3B Bos taurus (Bovine) 284 glycogen metabolic process [GO:0005977]; regulation of glycogen catabolic process [GO:0005981] GO:0005977; GO:0005981 0 0 0 PF03370; B2RU80 CHOYP_LOC663785.1.3 m.31447 sp PTPRB_MOUSE 36.735 441 237 15 717 1140 1569 1984 8.48E-72 267 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; D3YXG0 CHOYP_HMCN1.20.44 m.39503 sp HMCN1_MOUSE 23.25 1600 976 64 65 1586 1456 2881 8.48E-72 271 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O14776 CHOYP_TCERG1.1.1 m.32201 sp TCRG1_HUMAN 65.315 222 75 2 8 227 854 1075 8.48E-92 296 TCRG1_HUMAN reviewed Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150) TCERG1 CA150 TAF2S Homo sapiens (Human) 1098 negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription from RNA polymerase II promoter [GO:0006366] GO:0000122; GO:0001103; GO:0001106; GO:0003713; GO:0005634; GO:0005730; GO:0006366; GO:0015629; GO:0044822 0 0 0 PF01846;PF00397; P27401 CHOYP_LOC100679608.3.3 m.55829 sp POL_SFV3L 25.221 226 146 7 18 226 200 419 8.48E-14 75.9 POL_SFV3L reviewed Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)] pol Simian foamy virus type 3 (strain LK3) (SFVagm) (SFV-3) 1143 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718]; viral penetration into host nucleus [GO:0075732] GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0006310; GO:0015074; GO:0019012; GO:0030430; GO:0042025; GO:0046718; GO:0046872; GO:0075713; GO:0075732 0 0 0 PF00075;PF00665;PF00078;PF03539; Q15042 CHOYP_RB3GP.2.2 m.62359 sp RB3GP_HUMAN 52.778 108 45 2 1 103 874 980 8.48E-26 103 RB3GP_HUMAN reviewed Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) RAB3GAP1 KIAA0066 RAB3GAP Homo sapiens (Human) 981 brain development [GO:0007420]; camera-type eye development [GO:0043010]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; excitatory postsynaptic potential [GO:0060079]; face morphogenesis [GO:0060325]; hypothalamus development [GO:0021854]; lipid particle organization [GO:0034389]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein lipidation [GO:1903061]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of GTPase activity [GO:0043087]; regulation of short-term neuronal synaptic plasticity [GO:0048172] GO:0005085; GO:0005096; GO:0005789; GO:0005794; GO:0005811; GO:0007420; GO:0010628; GO:0017137; GO:0021854; GO:0034389; GO:0043010; GO:0043087; GO:0043234; GO:0043547; GO:0048172; GO:0060079; GO:0060325; GO:0061646; GO:0070062; GO:0071782; GO:0097051; GO:0098794; GO:1903061; GO:1903233; GO:1903373; GO:2000786 0 0 0 PF13890; Q1JPJ9 CHOYP_LOC100889152.1.1 m.10694 sp EF2KT_BOVIN 41.317 167 95 1 53 219 50 213 8.48E-37 140 EF2KT_BOVIN reviewed Protein-lysine N-methyltransferase EEF2KMT (EC 2.1.1.-) (eEF2-lysine methyltransferase) (eEF2-KMT) EEF2KMT FAM86A Bos taurus (Bovine) 340 peptidyl-lysine trimethylation [GO:0018023] GO:0005737; GO:0016279; GO:0018023 0 0 0 PF14904;PF10294; Q4A3R3 CHOYP_BRAFLDRAFT_120139.3.5 m.45799 sp DMBT1_PIG 28.516 512 305 16 37 531 648 1115 8.48E-36 149 DMBT1_PIG reviewed Deleted in malignant brain tumors 1 protein (Hensin) DMBT1 Sus scrofa (Pig) 1204 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0007275; GO:0015031; GO:0016021; GO:0019898; GO:0030154; GO:0030658; GO:0035375; GO:0042589 0 0 0 PF00431;PF00530;PF00100; Q6TNS2 CHOYP_PK1IP.1.1 m.49465 sp PK1IP_DANRE 45.151 299 158 3 6 304 12 304 8.48E-92 283 PK1IP_DANRE reviewed p21-activated protein kinase-interacting protein 1-like (PAK1-interacting protein 1-like) pak1ip1 zgc:56683 Danio rerio (Zebrafish) (Brachydanio rerio) 368 negative regulation of signal transduction [GO:0009968] GO:0005730; GO:0009968 0 0 0 PF12894;PF00400; Q7L1T6 CHOYP_NB5R4.1.1 m.57501 sp NB5R4_HUMAN 42.697 534 288 4 39 571 3 519 8.48E-158 464 NB5R4_HUMAN reviewed Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R) CYB5R4 NCB5OR Homo sapiens (Human) 521 bicarbonate transport [GO:0015701]; cell development [GO:0048468]; detection of oxygen [GO:0003032]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; NADP metabolic process [GO:0006739]; oxidation-reduction process [GO:0055114]; response to antibiotic [GO:0046677]; superoxide metabolic process [GO:0006801] GO:0003032; GO:0003958; GO:0004128; GO:0005783; GO:0005789; GO:0006091; GO:0006739; GO:0006801; GO:0015701; GO:0016174; GO:0016653; GO:0020037; GO:0030073; GO:0042593; GO:0046677; GO:0046872; GO:0048468; GO:0048471; GO:0055114; GO:0071949 0 0 0 PF04969;PF00173;PF00970;PF00175; Q86TZ1 CHOYP_LOC587791.1.3 m.8679 sp TTC6_HUMAN 46.465 396 212 0 1795 2190 121 516 8.48E-115 379 TTC6_HUMAN reviewed Tetratricopeptide repeat protein 6 (TPR repeat protein 6) TTC6 Homo sapiens (Human) 520 0 0 0 0 0 PF00515;PF13181; Q9ESN6 CHOYP_LOC100374741.70.83 m.60164 sp TRIM2_MOUSE 29.612 206 128 9 73 271 536 731 8.48E-12 68.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HC62 CHOYP_RB6I2.2.2 m.65653 sp SENP2_HUMAN 22.778 180 120 7 236 399 411 587 8.48E-06 52 SENP2_HUMAN reviewed Sentrin-specific protease 2 (EC 3.4.22.68) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 Homo sapiens (Human) 589 "dorsal/ventral axis specification [GO:0009950]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; labyrinthine layer development [GO:0060711]; mRNA transport [GO:0051028]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of DNA endoreduplication [GO:0032875]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of Wnt signaling pathway [GO:0030111]; spongiotrophoblast layer development [GO:0060712]; trophoblast giant cell differentiation [GO:0060707]; Wnt signaling pathway [GO:0016055]" GO:0001934; GO:0004175; GO:0005643; GO:0005654; GO:0007507; GO:0009950; GO:0015031; GO:0016055; GO:0016605; GO:0016925; GO:0016926; GO:0016929; GO:0030111; GO:0031397; GO:0031398; GO:0031410; GO:0031648; GO:0031965; GO:0032091; GO:0032875; GO:0035562; GO:0043518; GO:0045444; GO:0045944; GO:0051028; GO:0060707; GO:0060711; GO:0060712; GO:0070139; GO:2000045 0 0 0 PF02902; Q9NSN8 CHOYP_ALDR.1.1 m.50077 sp SNTG1_HUMAN 32.407 216 112 4 4 188 9 221 8.48E-25 103 SNTG1_HUMAN reviewed Gamma-1-syntrophin (G1SYN) (Syntrophin-4) (SYN4) SNTG1 Homo sapiens (Human) 517 cell communication [GO:0007154]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005198; GO:0005634; GO:0005737; GO:0005856; GO:0007154; GO:0008022; GO:0016013; GO:0032587; GO:0098779; GO:0098792 0 0 0 PF00595; Q9QYP2 CHOYP_TRIADDRAFT_62266.1.1 m.38390 sp CELR2_RAT 23.438 448 274 14 197 584 1150 1588 8.48E-25 113 CELR2_RAT reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) (Fragment) Celsr2 Megf3 Rattus norvegicus (Rat) 2144 cell surface receptor signaling pathway [GO:0007166]; dendrite morphogenesis [GO:0048813]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of cell-cell adhesion [GO:0022407]; spermatogenesis [GO:0007283] GO:0004930; GO:0005509; GO:0005886; GO:0007156; GO:0007166; GO:0007283; GO:0016021; GO:0022407; GO:0048813 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF00053;PF02210; Q9VCX1 CHOYP_LOC100889318.1.1 m.61506 sp RGS_DROME 31.57 605 342 14 849 1416 819 1388 8.48E-72 270 RGS_DROME reviewed Regulator of G-protein signaling loco (RGS) (Locomotion defects protein) (Loco) loco CG5248 Drosophila melanogaster (Fruit fly) 1541 "adult chitin-containing cuticle pigmentation [GO:0048085]; asymmetric neuroblast division [GO:0055059]; asymmetric protein localization [GO:0008105]; axon ensheathment in central nervous system [GO:0032291]; cell cycle [GO:0007049]; cortical actin cytoskeleton organization [GO:0030866]; cytoplasmic transport, nurse cell to oocyte [GO:0007303]; defense response to fungus [GO:0050832]; dorsal/ventral axis specification, ovarian follicular epithelium [GO:0008069]; embryonic axis specification [GO:0000578]; establishment of endothelial blood-brain barrier [GO:0014045]; establishment of glial blood-brain barrier [GO:0060857]; glial cell differentiation [GO:0010001]; G-protein coupled receptor signaling pathway [GO:0007186]; heart process [GO:0003015]; oocyte dorsal/ventral axis specification [GO:0007310]; regulation of asymmetric cell division [GO:0009786]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]; response to starvation [GO:0042594]; septate junction assembly [GO:0019991]; ventral cord development [GO:0007419]" GO:0000578; GO:0001965; GO:0003015; GO:0005057; GO:0005092; GO:0005096; GO:0005737; GO:0005829; GO:0005886; GO:0006979; GO:0007049; GO:0007186; GO:0007303; GO:0007310; GO:0007419; GO:0008069; GO:0008105; GO:0008277; GO:0009408; GO:0009786; GO:0010001; GO:0014045; GO:0016324; GO:0019991; GO:0030866; GO:0032291; GO:0042594; GO:0045179; GO:0048085; GO:0050832; GO:0055059; GO:0060857 0 0 0 PF00595;PF02196;PF00615; O94581 CHOYP_CC1G_13336.2.3 m.33223 sp COX12_SCHPO 59.722 72 29 0 95 166 15 86 8.49E-24 92 COX12_SCHPO reviewed Cytochrome c oxidase subunit 6B (Cytochrome c oxidase polypeptide VIb) cox12 SPCC1442.08c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 86 0 GO:0004129; GO:0005634; GO:0005739; GO:0005829 0 0 0 PF02297; P29691 CHOYP_EEF2.2.2 m.54906 sp EF2_CAEEL 70.934 289 83 1 1 288 169 457 8.49E-145 430 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P83095 CHOYP_BRAFLDRAFT_126051.1.1 m.10364 sp LACTB_BOVIN 46.07 458 186 8 108 521 109 549 8.49E-126 382 LACTB_BOVIN reviewed "Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)" LACTB Bos taurus (Bovine) 556 0 GO:0005739; GO:0016787 0 0 0 PF00144; Q08013 CHOYP_ISCW_ISCW008596.2.2 m.44076 sp SSRG_RAT 69.149 188 53 2 28 213 1 185 8.49E-93 272 SSRG_RAT reviewed Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma) Ssr3 Rattus norvegicus (Rat) 185 SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0005784; GO:0006614; GO:0016021 0 0 0 PF07074; Q2QKL5 CHOYP_PCS-1.1.1 m.8305 sp PCS3_LOTJA 52.804 214 99 2 61 273 6 218 8.49E-79 257 PCS3_LOTJA reviewed Glutathione gamma-glutamylcysteinyltransferase 3 (EC 2.3.2.15) (LjPCS3-7N) (Phytochelatin synthase 3) PCS3 Lotus japonicus (Lotus corniculatus var. japonicus) 479 phytochelatin biosynthetic process [GO:0046938]; response to metal ion [GO:0010038] GO:0010038; GO:0016756; GO:0046872; GO:0046938 0 0 0 PF05023;PF09328; Q3SWX0 CHOYP_LOC100864977.1.1 m.50734 sp NIPA2_BOVIN 47.479 238 123 1 1 238 101 336 8.49E-77 239 NIPA2_BOVIN reviewed Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2 homolog) NIPA2 Bos taurus (Bovine) 360 magnesium ion transport [GO:0015693] GO:0005769; GO:0005886; GO:0015095; GO:0015693; GO:0016021 0 0 0 PF05653; Q4R5M4 CHOYP_LOC100186067.1.1 m.62544 sp YIPF5_MACFA 56.4 250 105 2 47 292 8 257 8.49E-93 278 YIPF5_MACFA reviewed Protein YIPF5 (YIP1 family member 5) YIPF5 QccE-13521 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 257 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0015031; GO:0016021; GO:0016192; GO:0030134; GO:0032580 0 0 0 PF04893; Q5RD73 CHOYP_DUPD1.1.1 m.9288 sp DUS3_PONAB 43.871 155 86 1 38 191 26 180 8.49E-43 144 DUS3_PONAB reviewed Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Vaccinia H1-related phosphatase) (VHR) DUSP3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 185 dephosphorylation [GO:0016311]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of JNK cascade [GO:0046329]; negative regulation of T cell activation [GO:0050868]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of mitotic cell cycle [GO:0045931] GO:0001772; GO:0004725; GO:0005654; GO:0005829; GO:0008138; GO:0016311; GO:0016791; GO:0033549; GO:0045931; GO:0046329; GO:0050860; GO:0050868; GO:0070062; GO:0070373 0 0 0 PF00782; Q5ZML6 CHOYP_F210A.1.1 m.22048 sp F210A_CHICK 29.921 254 148 8 31 273 12 246 8.49E-30 116 F210A_CHICK reviewed Protein FAM210A FAM210A RCJMB04_1k21 Gallus gallus (Chicken) 275 0 GO:0005739; GO:0016021 0 0 0 PF06916; Q75WF2 CHOYP_DNA2.4.5 m.61721 sp DNA2_ACAPL 33.673 294 165 10 43 315 7 291 8.49E-39 143 DNA2_ACAPL reviewed Plancitoxin-1 (EC 3.1.22.1) (Plancitoxin I) (Plan-I) [Cleaved into: Plancitoxin-1 subunit alpha; Plancitoxin-1 subunit beta] 0 Acanthaster planci (Crown-of-thorns starfish) 358 apoptotic process [GO:0006915] GO:0004531; GO:0005576; GO:0006915 0 0 0 PF03265; Q86Y13 CHOYP_NEMVEDRAFT_V1G242728.2.2 m.64377 sp DZIP3_HUMAN 34.568 81 53 0 68 148 460 540 8.49E-07 55.1 DZIP3_HUMAN reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138) DZIP3 KIAA0675 Homo sapiens (Human) 1208 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8JG38 CHOYP_FGFR2.2.3 m.53947 sp FGFR2_DANRE 34.459 296 168 8 683 957 464 754 8.49E-36 150 FGFR2_DANRE reviewed Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) fgfr2 Danio rerio (Zebrafish) (Brachydanio rerio) 817 apoptotic process [GO:0006915]; cell proliferation in midbrain [GO:0033278]; cilium assembly [GO:0042384]; determination of heart left/right asymmetry [GO:0061371]; determination of left/right asymmetry in lateral mesoderm [GO:0003140]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; digestive tract development [GO:0048565]; midbrain development [GO:0030901]; positive regulation of cell proliferation [GO:0008284] GO:0003140; GO:0005007; GO:0005524; GO:0005794; GO:0005886; GO:0006915; GO:0008284; GO:0016021; GO:0016023; GO:0017134; GO:0030901; GO:0033278; GO:0035469; GO:0042384; GO:0048565; GO:0061371; GO:0071910 0 0 0 PF07679;PF07714; Q8NB14 CHOYP_BRAFLDRAFT_125949.1.1 m.62117 sp UBP38_HUMAN 36.045 627 376 11 1 609 1 620 8.49E-132 425 UBP38_HUMAN reviewed Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38) USP38 KIAA1891 Homo sapiens (Human) 1042 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0016579 0 0 0 PF00443; Q96RJ6 CHOYP_FER3.1.1 m.66097 sp FER3L_HUMAN 65.333 75 26 0 116 190 90 164 8.49E-28 106 FER3L_HUMAN reviewed Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist) FERD3L BHLHA31 NATO3 NTWIST Homo sapiens (Human) 166 "cell development [GO:0048468]; floor plate development [GO:0033504]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of neurogenesis [GO:0050767]; transcription, DNA-templated [GO:0006351]" GO:0000977; GO:0001227; GO:0005634; GO:0006351; GO:0033504; GO:0045892; GO:0048468; GO:0050767 0 0 0 PF00010; Q99973 CHOYP_BRAFLDRAFT_128562.1.4 m.33436 sp TEP1_HUMAN 39.314 379 188 4 286 663 239 576 8.49E-85 295 TEP1_HUMAN reviewed Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 telomerase homolog) TEP1 TLP1 TP1 Homo sapiens (Human) 2627 telomere maintenance via recombination [GO:0000722] GO:0000722; GO:0000781; GO:0002039; GO:0003720; GO:0003723; GO:0005524; GO:0005697; GO:0005737; GO:0016363; GO:0019899; GO:0030529; GO:0070034 0 0 0 PF13271;PF05386;PF05731;PF00400; Q9DA01 CHOYP_EPPI.2.2 m.43281 sp EPPI_MOUSE 33.557 149 83 4 1 149 1 133 8.49E-21 85.1 EPPI_MOUSE reviewed Eppin (Epididymal protease inhibitor) (Serine protease inhibitor-like with Kunitz and WAP domains 1) Eppin Spinlw1 Mus musculus (Mouse) 134 defense response to bacterium [GO:0042742]; negative regulation of peptidase activity [GO:0010466] GO:0001669; GO:0004867; GO:0005576; GO:0005737; GO:0009986; GO:0010466; GO:0042742 0 0 0 PF00014;PF00095; C9EIC7 CHOYP_NEMVEDRAFT_V1G238825.1.1 m.4703 sp ACTP1_URTCR 27.941 204 139 7 39 237 18 218 8.50E-15 74.3 ACTP1_URTCR reviewed DELTA-actitoxin-Ucs1a (DELTA-AITX-Ucs1a) (Cytolysin urticinatoxin) (UcI) 0 Urticina crassicornis (Mottled anemone) (Tealia crassicornis) 221 cation transport [GO:0006812]; hemolysis in other organism involved in symbiotic interaction [GO:0052331]; pore complex assembly [GO:0046931] GO:0005576; GO:0006812; GO:0015267; GO:0042151; GO:0044218; GO:0046930; GO:0046931; GO:0052331 0 0 0 PF06369; D2GXS7 CHOYP_LOC100369333.26.32 m.53344 sp TRIM2_AILME 23.552 259 180 7 96 339 488 743 8.50E-11 66.6 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P83088 CHOYP_ISCW_ISCW004236.2.5 m.9580 sp FUCTC_DROME 29.845 258 145 8 116 351 157 400 8.50E-28 116 FUCTC_DROME reviewed "Alpha-(1,3)-fucosyltransferase C (EC 2.4.1.-) (Galactoside 3-L-fucosyltransferase)" FucTC CG40305 Drosophila melanogaster (Fruit fly) 425 protein glycosylation [GO:0006486] GO:0006486; GO:0008417; GO:0016021; GO:0032580 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; P83425 CHOYP_BRAFLDRAFT_69134.1.13 m.8926 sp HIP_MYTED 28.767 146 95 5 84 226 73 212 8.50E-09 57.4 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q8CDM4 CHOYP_BRAFLDRAFT_82967.1.1 m.46910 sp CCD73_MOUSE 30.638 235 155 2 22 252 11 241 8.50E-13 73.6 CCD73_MOUSE reviewed Coiled-coil domain-containing protein 73 Ccdc73 Mus musculus (Mouse) 1066 0 0 0 0 0 PF15818; Q8K3K9 CHOYP_LOC100732570.2.2 m.27971 sp GIMA4_RAT 36.406 217 134 2 43 259 30 242 8.50E-42 150 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9BWF2 CHOYP_TRAIP.1.1 m.18139 sp TRAIP_HUMAN 27.902 491 292 18 1 455 3 467 8.50E-39 149 TRAIP_HUMAN reviewed E3 ubiquitin-protein ligase TRAIP (EC 6.3.2.-) (RING finger protein 206) (TRAF-interacting protein) TRAIP RNF206 TRIP Homo sapiens (Human) 469 apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; intracellular signal transduction [GO:0035556]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; signal transduction [GO:0007165] GO:0005057; GO:0005730; GO:0006915; GO:0007165; GO:0008270; GO:0008283; GO:0010804; GO:0016874; GO:0032688; GO:0035556; GO:0048471; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q9QXW2 CHOYP_LOC412155.1.2 m.7900 sp FBXW5_MOUSE 32.605 595 334 16 46 625 9 551 8.50E-81 269 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; B3EWY9 CHOYP_contig_013104 m.15041 sp MLP_ACRMI 29.373 1069 592 45 170 1172 394 1365 8.51E-96 347 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; P20273 CHOYP_TITIN.4.19 m.19569 sp CD22_HUMAN 24.466 421 272 19 162 559 234 631 8.51E-18 92.8 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P49183 CHOYP_LOC100368897.2.2 m.42615 sp DNAS1_MOUSE 43.396 265 138 4 36 293 23 282 8.51E-64 210 DNAS1_MOUSE reviewed Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) Dnase1 Dnl1 Mus musculus (Mouse) 284 apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308] GO:0004530; GO:0005634; GO:0005635; GO:0006308; GO:0006915; GO:0070062 0 0 0 0 Q5ZIJ9 CHOYP_MIB2.2.6 m.23029 sp MIB2_CHICK 32.589 896 512 23 411 1253 9 865 8.51E-133 434 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q7N571 CHOYP_TRIADDRAFT_53759.1.1 m.7789 sp GHRA_PHOLL 36.641 131 82 1 46 176 184 313 8.51E-23 95.5 GHRA_PHOLL reviewed Glyoxylate/hydroxypyruvate reductase A (EC 1.1.1.79) (EC 1.1.1.81) (2-ketoacid reductase) ghrA plu2086 Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 313 0 GO:0005737; GO:0005886; GO:0016618; GO:0030267; GO:0051287 0 0 0 PF02826; Q9UA35 CHOYP_S28A3.2.3 m.7477 sp S28A3_EPTST 43.152 533 275 6 4 536 103 607 8.51E-144 432 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; A0A0R4IBK5 CHOYP_BRAFLDRAFT_68766.4.4 m.38248 sp R213A_DANRE 42.791 215 111 4 1 208 3157 3366 8.52E-50 177 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O88854 CHOYP_LOC584740.1.2 m.25273 sp GALR2_MOUSE 24.024 333 206 11 26 352 14 305 8.52E-10 63.2 GALR2_MOUSE reviewed Galanin receptor type 2 (GAL2-R) (GALR-2) Galr2 Galnr2 Mus musculus (Mouse) 371 adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; inositol phosphate metabolic process [GO:0043647]; negative regulation of adenylate cyclase activity [GO:0007194]; neuron projection development [GO:0031175]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of large conductance calcium-activated potassium channel activity [GO:1902608]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944] GO:0004966; GO:0005829; GO:0005887; GO:0007188; GO:0007189; GO:0007194; GO:0007200; GO:0007204; GO:0017046; GO:0031175; GO:0042923; GO:0043647; GO:0045944; GO:0046488; GO:1902608 0 0 0 PF00001; P11536 CHOYP_E74EA.1.2 m.26003 sp E74EB_DROME 82.857 105 18 0 372 476 779 883 8.52E-56 202 E74EB_DROME reviewed Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) Eip74EF E74 CG32180 Drosophila melanogaster (Fruit fly) 883 "autophagy [GO:0006914]; cell death [GO:0008219]; oogenesis [GO:0048477]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of development, heterochronic [GO:0040034]; salivary gland cell autophagic cell death [GO:0035071]" GO:0001077; GO:0003700; GO:0005634; GO:0006914; GO:0008219; GO:0035071; GO:0040034; GO:0043565; GO:0045944; GO:0048477 0 0 0 PF00178; P16157 CHOYP_LOC754035.6.6 m.61136 sp ANK1_HUMAN 37.457 291 182 0 2 292 220 510 8.52E-52 186 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q3T147 CHOYP_LOC101067857.1.1 m.36994 sp DX39B_BOVIN 85.484 124 16 2 1 122 1 124 8.52E-68 213 DX39B_BOVIN reviewed Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (DEAD box protein UAP56) DDX39B BAT1 UAP56 Bos taurus (Bovine) 428 "cellular response to DNA damage stimulus [GO:0006974]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA damage checkpoint [GO:2000002]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; regulation of gene expression [GO:0010468]; RNA secondary structure unwinding [GO:0010501]; spliceosomal complex assembly [GO:0000245]; viral mRNA export from host cell nucleus [GO:0046784]" GO:0000245; GO:0000346; GO:0000398; GO:0004004; GO:0005524; GO:0005681; GO:0005687; GO:0005688; GO:0005737; GO:0006406; GO:0006974; GO:0010468; GO:0010501; GO:0016607; GO:0017070; GO:0030621; GO:0032786; GO:0044822; GO:0046784; GO:2000002 0 0 0 PF00270;PF00271; Q3V050 CHOYP_SLC47A1.1.1 m.49051 sp S47A2_MOUSE 41.265 332 193 2 23 353 155 485 8.52E-78 255 S47A2_MOUSE reviewed Multidrug and toxin extrusion protein 2 (MATE-2) (mMATE-2) (H(+)/organic cation antiporter kidney-specific) (Solute carrier family 47 member 2) Slc47a2 Mate2 Mus musculus (Mouse) 573 drug transmembrane transport [GO:0006855] GO:0006855; GO:0015238; GO:0015297; GO:0016021 0 0 0 PF01554; Q86VB7 CHOYP_DMBT1.3.34 m.3602 sp C163A_HUMAN 56.863 102 40 3 203 302 159 258 8.52E-27 114 C163A_HUMAN reviewed Scavenger receptor cysteine-rich type 1 protein M130 (Hemoglobin scavenger receptor) (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Homo sapiens (Human) 1156 acute-phase response [GO:0006953]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005576; GO:0005886; GO:0005887; GO:0006898; GO:0006953; GO:0030666 0 0 0 PF00530; Q94KD8 CHOYP_LOC100375100.1.1 m.39788 sp BXL2_ARATH 33.243 740 415 23 38 729 44 752 8.52E-111 357 BXL2_ARATH reviewed Probable beta-D-xylosidase 2 (AtBXL2) (EC 3.2.1.-) BXL2 At1g02640 T14P4.11 T14P4.8 Arabidopsis thaliana (Mouse-ear cress) 768 arabinan catabolic process [GO:0031222]; xylan catabolic process [GO:0045493] GO:0005578; GO:0009044; GO:0009505; GO:0031222; GO:0045493; GO:0046556 0 0 0 PF14310;PF00933;PF01915; O17320 CHOYP_LOC101470738.2.2 m.26123 sp ACT_CRAGI 97.902 143 3 0 1 143 1 143 8.53E-103 303 ACT_CRAGI reviewed Actin 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; P05389 CHOYP_LOC100199163.1.1 m.23020 sp RLA2_DROME 63.077 65 24 0 1 65 1 65 8.53E-21 82.8 RLA2_DROME reviewed 60S acidic ribosomal protein P2 (Acidic ribosomal protein RPA1) RpLP2 rpA1 RpP1 CG4918 Drosophila melanogaster (Fruit fly) 113 cytoplasmic translation [GO:0002181]; translational elongation [GO:0006414] GO:0002181; GO:0003735; GO:0005840; GO:0006414; GO:0022625; GO:0030687; GO:0070180 0 0 0 0 P86854 CHOYP_CD209.1.6 m.3303 sp PLCL_MYTGA 32.394 142 92 3 288 427 17 156 8.53E-19 86.3 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q10725 CHOYP_BRAFLDRAFT_62156.1.1 m.47958 sp FSDH_RALPI 31.692 325 213 7 6 327 5 323 8.53E-46 161 FSDH_RALPI reviewed Phenylserine dehydratase (EC 4.2.1.-) psdht Ralstonia pickettii (Burkholderia pickettii) 326 0 GO:0016829 0 0 0 PF00291; Q4ZJM9 CHOYP_contig_001554 m.1669 sp C1QL4_MOUSE 34.021 97 60 2 67 161 113 207 8.53E-07 50.8 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5R8Y8 CHOYP_CELF2.4.4 m.62924 sp CELF2_PONAB 53.417 556 176 15 14 555 22 508 8.53E-179 516 CELF2_PONAB reviewed CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (RNA-binding protein BRUNOL-3) CELF2 CUGBP2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 508 mRNA splice site selection [GO:0006376] GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006376 0 0 0 PF00076; Q61097 CHOYP_KSR2.1.1 m.9851 sp KSR1_MOUSE 35.609 879 449 21 12 835 32 848 8.53E-149 462 KSR1_MOUSE reviewed Kinase suppressor of Ras 1 (mKSR1) (Protein Hb) Ksr1 Ksr Mus musculus (Mouse) 873 cAMP-mediated signaling [GO:0019933]; positive regulation of MAPK cascade [GO:0043410]; Ras protein signal transduction [GO:0007265] GO:0004672; GO:0005078; GO:0005524; GO:0005783; GO:0005789; GO:0007265; GO:0008022; GO:0016020; GO:0019933; GO:0032587; GO:0043234; GO:0043410; GO:0046872 0 0 0 PF13543;PF07714; Q9D2J7 CHOYP_TURPA_3490.1.1 m.13032 sp ANKE1_MOUSE 45.882 85 40 3 9 89 503 585 8.53E-12 63.9 ANKE1_MOUSE reviewed Ankyrin repeat and EF-hand domain-containing protein 1 (Ankyrin repeat domain-containing protein 5) Ankef1 Ankrd5 Mus musculus (Mouse) 775 0 0 0 0 0 PF12796; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.12.15 m.53253 sp SACS_MOUSE 29.902 923 539 32 1 852 1090 1975 8.53E-98 339 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; Q9R1R2 CHOYP_LOC100376215.18.19 m.53304 sp TRIM3_MOUSE 26.25 160 108 4 27 180 115 270 8.53E-06 51.6 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9VU02 CHOYP_LOC552559.2.2 m.53602 sp SMD1_DROME 84.615 91 14 0 1 91 1 91 8.53E-54 167 SMD1_DROME reviewed Probable small nuclear ribonucleoprotein Sm D1 (Sm-D1) (snRNP core protein D1) SmD1 snRNP69D CG10753 Drosophila melanogaster (Fruit fly) 124 "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]" GO:0000243; GO:0000245; GO:0000387; GO:0000398; GO:0003723; GO:0005634; GO:0005681; GO:0005682; GO:0005685; GO:0005686; GO:0005687; GO:0005689; GO:0005829; GO:0030532; GO:0034715; GO:0034719; GO:0044822; GO:0071010; GO:0071011; GO:0071013; GO:0097526 0 0 0 PF01423; Q9VY77 CHOYP_LOC408431.1.1 m.18046 sp AJUBA_DROME 64.605 291 97 3 333 618 436 725 8.53E-130 404 AJUBA_DROME reviewed LIM domain-containing protein jub jub CG11063 Drosophila melanogaster (Fruit fly) 728 hippo signaling [GO:0035329]; mitotic nuclear division [GO:0007067]; ovarian follicle cell development [GO:0030707]; positive regulation of imaginal disc growth [GO:0045572]; positive regulation of organ growth [GO:0046622]; protein localization to centrosome [GO:0071539] GO:0003779; GO:0005911; GO:0005912; GO:0007067; GO:0008270; GO:0030707; GO:0035329; GO:0045177; GO:0045179; GO:0045572; GO:0046622; GO:0071539 0 0 0 PF00412; Q9Y493 CHOYP_STAR.1.4 m.6979 sp ZAN_HUMAN 34.722 360 213 10 98 448 683 1029 8.53E-06 53.1 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; B1AS42 CHOYP_LOC100373304.1.1 m.49161 sp NB5R5_MOUSE 38.542 288 166 4 66 347 18 300 8.54E-65 211 NB5R5_MOUSE reviewed NADH-cytochrome b5 reductase-like (EC 1.6.2.2) Cyb5rl Mus musculus (Mouse) 316 0 GO:0004128; GO:0005634; GO:0005654; GO:0071949 0 0 0 PF00970;PF00175;PF09791; G5ED84 CHOYP_LOC100698240.3.4 m.17110 sp KLHL8_CAEEL 25.654 191 133 4 10 192 88 277 8.54E-11 68.6 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O70277 CHOYP_BRAFLDRAFT_82426.12.20 m.46771 sp TRIM3_RAT 29.412 119 79 3 43 158 627 743 8.54E-07 50.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_LOC100893879.3.3 m.46071 sp TRIM3_RAT 26.613 124 90 1 40 163 115 237 8.54E-07 52.4 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P10079 CHOYP_LOC100634060.10.37 m.23349 sp FBP1_STRPU 56.19 210 92 0 180 389 291 500 8.54E-67 232 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P20481 CHOYP_BUCC.2.2 m.56998 sp BUCC_APLCA 42.373 118 38 4 63 180 335 422 8.54E-14 71.6 BUCC_APLCA reviewed Buccalin [Cleaved into: Buccalin-D; Buccalin-E; Buccalin-F; Buccalin-G; Buccalin-H; Buccalin-A; Buccalin-I; Buccalin-J; Buccalin-K; Buccalin-L; Buccalin-B (BUCb); Buccalin-M; Buccalin gene-predicted acidic peptide A (BGPAP A); Buccalin-N; Buccalin-O; Buccalin-P; Buccalin-Q; Buccalin-R; Buccalin-C; Buccalin-S; Buccalin gene-predicted acidic peptide B (BGPAP B)] 0 Aplysia californica (California sea hare) 505 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 0 P62890 CHOYP_LOC659206.1.6 m.3536 sp RL30_RAT 82.301 113 20 0 1 113 1 113 8.54E-62 201 RL30_RAT reviewed 60S ribosomal protein L30 Rpl30 Rattus norvegicus (Rat) 115 liver regeneration [GO:0097421]; positive regulation of selenocysteine incorporation [GO:1904571]; selenocysteine metabolic process [GO:0016259]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005829; GO:0005840; GO:0005925; GO:0006412; GO:0016020; GO:0016259; GO:0022625; GO:0035368; GO:0070062; GO:0097421; GO:1904571 0 0 0 PF01248; Q5R662 CHOYP_LRP12.2.2 m.55895 sp LRP12_PONAB 34.884 731 400 21 60 759 52 737 8.54E-111 361 LRP12_PONAB reviewed Low-density lipoprotein receptor-related protein 12 (LRP-12) LRP12 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 859 endocytosis [GO:0006897] GO:0005887; GO:0005905; GO:0006897 0 0 0 PF00431;PF00057; Q6PFY8 CHOYP_LOC100374741.38.83 m.33463 sp TRI45_MOUSE 21.739 207 153 4 11 210 133 337 8.54E-08 58.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9CZJ2 CHOYP_BRAFLDRAFT_208293.12.20 m.55398 sp HS12B_MOUSE 32.242 611 343 17 69 615 61 664 8.54E-88 290 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9D8Z1 CHOYP_ASCC1.1.1 m.39863 sp ASCC1_MOUSE 49.721 358 175 2 1 356 1 355 8.54E-127 370 ASCC1_MOUSE reviewed Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50) Ascc1 Mus musculus (Mouse) 356 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003723; GO:0005634; GO:0005667; GO:0006351; GO:0006355; GO:0031594 0 0 0 PF10469;PF00013; Q9QXW2 CHOYP_ISCW_ISCW008293.1.5 m.17384 sp FBXW5_MOUSE 27.727 220 150 7 7 222 9 223 8.54E-13 73.9 FBXW5_MOUSE reviewed F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5) Fbxw5 Fbw5 Mus musculus (Mouse) 573 centrosome duplication [GO:0051298]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0005737; GO:0007088; GO:0010824; GO:0016567; GO:0019005; GO:0019901; GO:0031146; GO:0043161; GO:0051298; GO:0080008 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; Q9TRY0 CHOYP_FKBP4.1.1 m.15147 sp FKBP4_BOVIN 51.79 419 198 1 192 606 21 439 8.54E-145 430 FKBP4_BOVIN reviewed "Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (FK506-binding protein 4) (FKBP-4) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]" FKBP4 Bos taurus (Bovine) 459 chaperone-mediated protein folding [GO:0061077]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977] GO:0003755; GO:0005528; GO:0005634; GO:0005739; GO:0005789; GO:0005829; GO:0005874; GO:0010977; GO:0031111; GO:0044295; GO:0061077 0 0 0 PF00254;PF00515;PF07719; P17454 CHOYP_LOC589952.5.5 m.57480 sp LBP_RABIT 26.623 462 321 8 24 477 28 479 8.55E-55 193 LBP_RABIT reviewed Lipopolysaccharide-binding protein (LBP) LBP Oryctolagus cuniculus (Rabbit) 482 acute-phase response [GO:0006953]; cellular defense response [GO:0006968]; defense response to Gram-negative bacterium [GO:0050829]; innate immune response [GO:0045087]; lipid transport [GO:0006869]; macrophage activation involved in immune response [GO:0002281]; opsonization [GO:0008228]; positive regulation of tumor necrosis factor production [GO:0032760] GO:0001530; GO:0002281; GO:0005102; GO:0005615; GO:0006869; GO:0006953; GO:0006968; GO:0008228; GO:0032760; GO:0045087; GO:0050829 0 0 0 PF01273;PF02886; P21941 CHOYP_TITIN.7.19 m.34906 sp MATN1_HUMAN 34.634 205 118 5 46 245 268 461 8.55E-28 122 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P56395 CHOYP_CYB5.1.2 m.2195 sp CYB5_MOUSE 56.25 128 53 2 12 138 8 133 8.55E-44 143 CYB5_MOUSE reviewed Cytochrome b5 Cyb5a Cyb5 Mus musculus (Mouse) 134 fatty acid metabolic process [GO:0006631]; response to cadmium ion [GO:0046686] GO:0004768; GO:0005737; GO:0005739; GO:0005789; GO:0006631; GO:0016020; GO:0016021; GO:0019899; GO:0020037; GO:0031090; GO:0043231; GO:0046686; GO:0046872; GO:0070062 0 0 0 PF00173; Q06805 CHOYP_MEGF10.8.12 m.38635 sp TIE1_BOVIN 37.234 94 53 3 183 274 213 302 8.55E-15 79.3 TIE1_BOVIN reviewed Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) TIE1 TIE TIE-1 Bos taurus (Bovine) 1136 angiogenesis [GO:0001525] GO:0001525; GO:0004714; GO:0005524; GO:0005886; GO:0016021 0 0 0 PF00041;PF00047;PF07714; Q5R1M5 CHOYP_CELA1.3.3 m.28808 sp CELA1_FELCA 40 255 141 7 2 250 16 264 8.55E-51 169 CELA1_FELCA reviewed Chymotrypsin-like elastase family member 1 (EC 3.4.21.36) (Elastase-1) CELA1 ELA1 ELS1 Felis catus (Cat) (Felis silvestris catus) 266 0 GO:0004252; GO:0005615; GO:0046872 0 0 cd00190; PF00089; Q5S006 CHOYP_BRAFLDRAFT_119973.2.3 m.46508 sp LRRK2_MOUSE 24.742 291 193 8 2 280 559 835 8.55E-09 60.8 LRRK2_MOUSE reviewed Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) Lrrk2 Mus musculus (Mouse) 2527 "activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; autophagy [GO:0006914]; calcium-mediated signaling [GO:0019722]; cellular protein localization [GO:0034613]; cellular response to dopamine [GO:1903351]; cellular response to manganese ion [GO:0071287]; cellular response to oxidative stress [GO:0034599]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; endocytosis [GO:0006897]; excitatory postsynaptic potential [GO:0060079]; exploration behavior [GO:0035640]; Golgi organization [GO:0007030]; GTP metabolic process [GO:0046039]; intracellular distribution of mitochondria [GO:0048312]; intracellular signal transduction [GO:0035556]; locomotory exploration behavior [GO:0035641]; lysosome organization [GO:0007040]; MAPK cascade [GO:0000165]; mitochondrion localization [GO:0051646]; mitochondrion organization [GO:0007005]; negative regulation of autophagosome assembly [GO:1902902]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of GTPase activity [GO:0034260]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron death [GO:1901215]; negative regulation of protein binding [GO:0032091]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of protein targeting to mitochondrion [GO:1903215]; negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [GO:1903125]; neuromuscular junction development [GO:0007528]; neuron death [GO:0070997]; neuron projection morphogenesis [GO:0048812]; olfactory bulb development [GO:0021772]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; phosphorylation [GO:0016310]; positive regulation of autophagy [GO:0010508]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of programmed cell death [GO:0043068]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein autoubiquitination [GO:1902499]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; regulation of autophagy [GO:0010506]; regulation of branching morphogenesis of a nerve [GO:2000172]; regulation of calcium-mediated signaling [GO:0050848]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of dopamine receptor signaling pathway [GO:0060159]; regulation of kidney size [GO:0035564]; regulation of locomotion [GO:0040012]; regulation of lysosomal lumen pH [GO:0035751]; regulation of membrane potential [GO:0042391]; regulation of mitochondrial depolarization [GO:0051900]; regulation of neuroblast proliferation [GO:1902692]; regulation of neuron death [GO:1901214]; regulation of neuron maturation [GO:0014041]; regulation of protein kinase A signaling [GO:0010738]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of synaptic vesicle exocytosis [GO:2000300]; regulation of synaptic vesicle transport [GO:1902803]; response to oxidative stress [GO:0006979]; small GTPase mediated signal transduction [GO:0007264]; synaptic vesicle recycling [GO:0036465]; tangential migration from the subventricular zone to the olfactory bulb [GO:0022028]; Wnt signalosome assembly [GO:1904887]" GO:0000149; GO:0000165; GO:0000186; GO:0000187; GO:0001933; GO:0001934; GO:0001948; GO:0003779; GO:0003924; GO:0004672; GO:0004674; GO:0004708; GO:0005096; GO:0005524; GO:0005525; GO:0005615; GO:0005622; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005759; GO:0005764; GO:0005768; GO:0005783; GO:0005794; GO:0005798; GO:0005802; GO:0005829; GO:0005886; GO:0005901; GO:0005902; GO:0006468; GO:0006897; GO:0006914; GO:0006979; GO:0007005; GO:0007030; GO:0007040; GO:0007264; GO:0007528; GO:0008021; GO:0008340; GO:0009267; GO:0010506; GO:0010508; GO:0010738; GO:0010955; GO:0014041; GO:0015631; GO:0016234; GO:0016242; GO:0016301; GO:0016310; GO:0017048; GO:0017075; GO:0018105; GO:0018107; GO:0019722; GO:0021772; GO:0022028; GO:0030054; GO:0030159; GO:0030276; GO:0030424; GO:0030425; GO:0030426; GO:0030529; GO:0030672; GO:0031398; GO:0031410; GO:0031966; GO:0032091; GO:0032092; GO:0032403; GO:0032436; GO:0032473; GO:0032839; GO:0034211; GO:0034260; GO:0034599; GO:0034613; GO:0035556; GO:0035564; GO:0035640; GO:0035641; GO:0035751; GO:0036465; GO:0036479; GO:0040012; GO:0042391; GO:0042802; GO:0042803; GO:0043005; GO:0043025; GO:0043068; GO:0043195; GO:0043204; GO:0044325; GO:0044753; GO:0044754; GO:0045121; GO:0045202; GO:0046039; GO:0046777; GO:0048312; GO:0048812; GO:0050848; GO:0051018; GO:0051646; GO:0051900; GO:0051966; GO:0060079; GO:0060159; GO:0060161; GO:0060828; GO:0061001; GO:0070062; GO:0070997; GO:0071287; GO:0072593; GO:0090263; GO:0090394; GO:0097487; GO:0098794; GO:1901214; GO:1901215; GO:1902236; GO:1902499; GO:1902692; GO:1902803; GO:1902902; GO:1903125; GO:1903206; GO:1903215; GO:1903351; GO:1904713; GO:1904887; GO:1990909; GO:2000172; GO:2000300 0 0 0 PF16095;PF12799;PF13855;PF00069;PF08477; Q6AXM9 CHOYP_CL029.1.1 m.52017 sp CL029_RAT 44.478 335 172 4 19 352 1 322 8.55E-97 293 CL029_RAT reviewed Uncharacterized protein C12orf29 homolog 0 Rattus norvegicus (Rat) 325 hematopoietic progenitor cell differentiation [GO:0002244] GO:0002244 0 0 0 0 Q91756 CHOYP_GRIA3.1.1 m.44173 sp GLRK_XENLA 27.412 456 288 12 27 479 45 460 8.55E-55 193 GLRK_XENLA reviewed Glutamate receptor U1 (Kainate-binding protein) (Unitary non-NMDA glutamate receptor subunit 1) (XENU1) kbp Xenopus laevis (African clawed frog) 479 0 GO:0004970; GO:0005234; GO:0016021; GO:0030054; GO:0045211 0 0 0 PF00060;PF10613; Q92851 CHOYP_CASP10.5.7 m.49889 sp CASPA_HUMAN 35.036 137 72 5 17 150 280 402 8.55E-14 77.8 CASPA_HUMAN reviewed Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] CASP10 MCH4 Homo sapiens (Human) 521 apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; macrophage differentiation [GO:0030225]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981] GO:0004197; GO:0005829; GO:0006915; GO:0007166; GO:0008625; GO:0030225; GO:0031265; GO:0031625; GO:0035877; GO:0042981; GO:0043123; GO:0097190; GO:0097199; GO:0097342 0 0 0 PF01335; Q96JL9 CHOYP_ISCW_ISCW002554.1.1 m.12577 sp ZN333_HUMAN 31.707 287 167 9 567 851 381 640 8.55E-29 127 ZN333_HUMAN reviewed Zinc finger protein 333 ZNF333 KIAA1806 Homo sapiens (Human) 665 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13912;PF13465; A2BD94 CHOYP_LOC100377168.2.3 m.42891 sp FB31B_XENLA 29.476 458 240 13 15 412 62 496 8.56E-50 179 FB31B_XENLA reviewed F-box only protein 31-B fbxo31-b Xenopus laevis (African clawed frog) 523 cellular response to DNA damage stimulus [GO:0006974]; mitotic G1 DNA damage checkpoint [GO:0031571]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146] GO:0006974; GO:0008054; GO:0016567; GO:0019005; GO:0031146; GO:0031571 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; A4IF63 CHOYP_BRAFLDRAFT_205965.33.43 m.52747 sp TRIM2_BOVIN 24.342 152 104 3 94 244 602 743 8.56E-06 50.4 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O00534 CHOYP_VMA5A.1.1 m.24860 sp VMA5A_HUMAN 32.118 850 469 24 6 824 5 777 8.56E-114 367 VMA5A_HUMAN reviewed von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein) VWA5A BCSC1 LOH11CR2A Homo sapiens (Human) 786 0 GO:0005634; GO:0005654 0 0 0 PF08487;PF13768; P10394 CHOYP_contig_011969 m.13736 sp POL4_DROME 30.167 958 585 14 205 1097 268 1206 8.56E-126 423 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P55567 CHOYP_BRAFLDRAFT_99018.1.1 m.14650 sp Y4MH_SINFN 28.136 295 189 7 9 283 6 297 8.56E-40 143 Y4MH_SINFN reviewed Uncharacterized protein y4mH NGR_a02510 y4mH Sinorhizobium fredii (strain NBRC 101917 / NGR234) 297 0 GO:0016787 0 0 0 PF04909; P78329 CHOYP_LOC100375647.1.2 m.39652 sp CP4F2_HUMAN 40.084 479 268 9 52 516 39 512 8.56E-127 383 CP4F2_HUMAN reviewed Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.13.194) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.13.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.13.30) CYP4F2 Homo sapiens (Human) 520 arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; oxidation-reduction process [GO:0055114]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377] GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006690; GO:0006691; GO:0007596; GO:0008217; GO:0008392; GO:0016324; GO:0016709; GO:0017144; GO:0018685; GO:0019369; GO:0019373; GO:0020037; GO:0031090; GO:0032304; GO:0032305; GO:0036101; GO:0042360; GO:0042361; GO:0042376; GO:0042377; GO:0043231; GO:0050051; GO:0052869; GO:0052871; GO:0052872; GO:0055078; GO:0055114; GO:0097258; GO:0097259; GO:0097267 PATHWAY: Cofactor degradation; phylloquinone degradation. {ECO:0000269|PubMed:24138531}. 0 0 PF00067; P86880 CHOYP_LOC763287.1.1 m.43472 sp NGB_CHAAC 34.395 157 95 4 31 183 4 156 8.56E-19 81.6 NGB_CHAAC reviewed Neuroglobin 0 Chaenocephalus aceratus (Blackfin icefish) (Chaenichthys aceratus) 159 0 GO:0005344; GO:0005737; GO:0019825; GO:0020037; GO:0043204; GO:0046872 0 0 0 PF00042; Q19269 CHOYP_LOC100374537.1.1 m.27241 sp NAS14_CAEEL 40.574 244 117 5 63 279 75 317 8.56E-48 176 NAS14_CAEEL reviewed Zinc metalloproteinase nas-14 (EC 3.4.24.21) (Nematode astacin 14) nas-14 F09E8.6 Caenorhabditis elegans 503 0 GO:0004222; GO:0005576; GO:0008270 0 0 0 PF01400;PF01549; Q496A3 CHOYP_LOC100374662.1.6 m.7038 sp SPAS1_HUMAN 34.228 149 68 4 108 228 142 288 8.56E-13 69.7 SPAS1_HUMAN reviewed Spermatogenesis-associated serine-rich protein 1 SPATS1 Homo sapiens (Human) 300 0 0 0 0 0 PF15160; Q5G266 CHOYP_LOC100635494.1.1 m.41591 sp NETR_TRAPH 25.532 235 147 8 28 242 177 403 8.56E-09 60.5 NETR_TRAPH reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Trachypithecus phayrei (Phayre's leaf monkey) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q5TH69 CHOYP_BIG3.1.1 m.51447 sp BIG3_HUMAN 31.307 773 433 24 362 1059 1426 2175 8.56E-101 354 BIG3_HUMAN reviewed Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF family member 3) ARFGEF3 BIG3 C6orf92 KIAA1244 Homo sapiens (Human) 2177 negative regulation of phosphatase activity [GO:0010923]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0010923; GO:0016021; GO:0030658; GO:0032012 0 0 0 PF16213;PF09324; Q9NUV9 CHOYP_LOC100331109.1.2 m.2735 sp GIMA4_HUMAN 41.637 281 149 7 102 374 28 301 8.56E-58 197 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9R1R2 CHOYP_LOC100373444.19.79 m.22750 sp TRIM3_MOUSE 24.291 247 172 8 260 496 482 723 8.56E-10 65.1 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; C9JTQ0 CHOYP_BRAFLDRAFT_127165.1.1 m.28756 sp ANR63_HUMAN 29.114 158 107 3 17 171 18 173 8.57E-14 76.3 ANR63_HUMAN reviewed Ankyrin repeat domain-containing protein 63 ANKRD63 Homo sapiens (Human) 380 0 0 0 0 0 PF12796; E1C1L6 CHOYP_ENTP5.1.1 m.7967 sp ENTP5_CHICK 43.117 385 204 8 93 466 46 426 8.57E-101 311 ENTP5_CHICK reviewed Ectonucleoside triphosphate diphosphohydrolase 5 (NTPDase 5) (EC 3.6.1.6) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (EC 3.6.1.42) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5) ENTPD5 Gallus gallus (Chicken) 428 'de novo' posttranslational protein folding [GO:0051084]; ATP metabolic process [GO:0046034]; cell growth [GO:0016049]; cell proliferation [GO:0008283]; positive regulation of glycolytic process [GO:0045821]; protein N-linked glycosylation [GO:0006487]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066] GO:0004382; GO:0005783; GO:0006487; GO:0008283; GO:0014066; GO:0016049; GO:0045134; GO:0045821; GO:0046034; GO:0051084; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01150; O70165 CHOYP_ANGP4.5.7 m.33715 sp FCN1_MOUSE 46.552 174 88 3 185 355 131 302 8.57E-42 151 FCN1_MOUSE reviewed Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin) Fcn1 Fcna Mus musculus (Mouse) 334 "cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation, lectin pathway [GO:0001867]; G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of interleukin-8 secretion [GO:2000484]" GO:0001867; GO:0002752; GO:0005576; GO:0005581; GO:0007186; GO:0008329; GO:0030246; GO:0031232; GO:0046872; GO:0097367; GO:2000484 0 0 0 PF01391;PF00147; O70277 CHOYP_BRAFLDRAFT_87319.5.5 m.46792 sp TRIM3_RAT 30 120 79 3 41 157 627 744 8.57E-10 59.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P29183 CHOYP_BRAFLDRAFT_224784.2.2 m.45952 sp LIPP_HORSE 38.71 217 120 6 80 283 70 286 8.57E-40 147 LIPP_HORSE reviewed Pancreatic triacylglycerol lipase (PL) (PTL) (Pancreatic lipase) (EC 3.1.1.3) (Fragment) PNLIP Equus caballus (Horse) 461 lipid catabolic process [GO:0016042] GO:0004806; GO:0005576; GO:0016042; GO:0046872 0 0 0 PF00151;PF01477; P58058 CHOYP_LOC100875114.1.1 m.40922 sp NADK_MOUSE 58.445 373 153 1 77 447 61 433 8.57E-147 429 NADK_MOUSE reviewed NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase) Nadk Mus musculus (Mouse) 439 NAD metabolic process [GO:0019674]; NADP biosynthetic process [GO:0006741] GO:0003951; GO:0005524; GO:0005829; GO:0006741; GO:0019674; GO:0046872 0 0 0 PF01513; Q5RCV1 CHOYP_BRAFLDRAFT_266463.1.2 m.22602 sp TM104_PONAB 53.333 165 69 3 3 165 261 419 8.57E-53 178 TM104_PONAB reviewed Transmembrane protein 104 TMEM104 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 496 0 GO:0016021 0 0 0 PF01490; Q6AZN8 CHOYP_ZNT6A.1.1 m.55810 sp ZNT6A_XENLA 62.393 351 127 2 32 381 1 347 8.57E-158 457 ZNT6A_XENLA reviewed Zinc transporter 6-A (ZnT-6-A) (Solute carrier family 30 member 6-A) slc30a6-a znt6-a Xenopus laevis (African clawed frog) 464 zinc II ion transport [GO:0006829] GO:0005794; GO:0006829; GO:0008324; GO:0016021 0 0 0 PF01545; Q8N8S7 CHOYP_ENA.1.2 m.49042 sp ENAH_HUMAN 66.327 98 33 0 43 140 3 100 8.57E-41 146 ENAH_HUMAN reviewed Protein enabled homolog ENAH MENA Homo sapiens (Human) 591 axon guidance [GO:0007411] GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0007411; GO:0030027; GO:0030054; GO:0030175; GO:0045202; GO:0050699 0 0 0 PF08776;PF00568; Q92982 CHOYP_LOC101441264.1.1 m.48880 sp NINJ1_HUMAN 33.333 102 61 3 47 144 43 141 8.57E-07 48.9 NINJ1_HUMAN reviewed Ninjurin-1 (Nerve injury-induced protein 1) NINJ1 Homo sapiens (Human) 152 cell adhesion [GO:0007155]; hyaloid vascular plexus regression [GO:1990384]; nervous system development [GO:0007399]; positive regulation of cell-matrix adhesion [GO:0001954]; tissue regeneration [GO:0042246] GO:0001954; GO:0007155; GO:0007399; GO:0016021; GO:0042246; GO:1990384 0 0 0 PF04923; Q96KG7 CHOYP_PHUM_PHUM049590.4.4 m.56740 sp MEG10_HUMAN 27.734 256 146 7 26 272 224 449 8.57E-10 65.1 MEG10_HUMAN reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) MEGF10 KIAA1780 Homo sapiens (Human) 1140 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q9BT30 CHOYP_CARNS1.2.6 m.3531 sp ALKB7_HUMAN 48.634 183 94 0 86 268 15 197 8.57E-60 192 ALKB7_HUMAN reviewed "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11)" ALKBH7 ABH7 SPATA11 UNQ6002/PRO34564 Homo sapiens (Human) 221 cellular response to DNA damage stimulus [GO:0006974]; fatty acid metabolic process [GO:0006631]; regulation of lipid storage [GO:0010883]; regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445] GO:0005759; GO:0006631; GO:0006974; GO:0010883; GO:0046872; GO:0051213; GO:1902445 0 0 0 PF13532; Q9NXS3 CHOYP_NEMVEDRAFT_V1G120526.1.5 m.482 sp KLH28_HUMAN 29.457 129 87 3 11 136 15 142 8.57E-08 58.9 KLH28_HUMAN reviewed Kelch-like protein 28 (BTB/POZ domain-containing protein 5) KLHL28 BTBD5 Homo sapiens (Human) 571 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0031463; GO:0042787 0 0 0 PF07707;PF00651;PF01344; D2HNW6 CHOYP_RFX6.2.2 m.28039 sp RFX6_AILME 40.928 237 134 2 1 232 341 576 8.58E-52 192 RFX6_AILME reviewed DNA-binding protein RFX6 (Regulatory factor X 6) RFX6 PANDA_013423 Ailuropoda melanoleuca (Giant panda) 928 "endocrine pancreas development [GO:0031018]; glucose homeostasis [GO:0042593]; pancreatic A cell differentiation [GO:0003310]; pancreatic D cell differentiation [GO:0003311]; pancreatic epsilon cell differentiation [GO:0090104]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of insulin secretion [GO:0050796]; type B pancreatic cell differentiation [GO:0003309]" GO:0000977; GO:0001228; GO:0003309; GO:0003310; GO:0003311; GO:0005634; GO:0031018; GO:0035774; GO:0042593; GO:0044212; GO:0045893; GO:0045944; GO:0050796; GO:0090104 0 0 0 PF02257; O01761 CHOYP_UNC-89.1.2 m.1625 sp UNC89_CAEEL 27.692 195 139 2 854 1047 5389 5582 8.58E-18 94.7 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O02485 CHOYP_SMP_194720.1.1 m.53496 sp YDJ1_CAEEL 38.438 333 175 6 114 442 11 317 8.58E-79 251 YDJ1_CAEEL reviewed Uncharacterized protein ZK1073.1 ZK1073.1 Caenorhabditis elegans 325 signal transduction [GO:0007165] GO:0005737; GO:0007165 0 0 0 PF03096; O57683 CHOYP_TRIADDRAFT_54034.1.1 m.66823 sp SF3B1_XENLA 50 108 51 3 13 118 31 137 8.58E-27 106 SF3B1_XENLA reviewed Splicing factor 3B subunit 1 (146 kDa nuclear protein) (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155) sf3b1 Xenopus laevis (African clawed frog) 1307 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005681; GO:0006397; GO:0008380 0 0 0 PF08920; O61462 CHOYP_RL37A.1.7 m.9950 sp RL37A_CRYST 86.957 92 12 0 17 108 1 92 8.58E-54 166 RL37A_CRYST reviewed 60S ribosomal protein L37a RPL37A Cryptochiton stelleri (Giant gumboot chiton) 92 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0046872 0 0 0 PF01780; P18503 CHOYP_BRAFLDRAFT_76550.9.21 m.49160 sp CAS4_EPHMU 34.677 124 61 4 80 200 207 313 8.58E-08 55.8 CAS4_EPHMU reviewed Short-chain collagen C4 (Fragment) 0 Ephydatia muelleri (Mueller's freshwater sponge) 366 0 GO:0005578; GO:0005581 0 0 0 PF01391; Q03601 CHOYP_NHL1.1.6 m.808 sp NHL1_CAEEL 32.143 112 64 4 55 157 772 880 8.58E-09 57.4 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q14DL3 CHOYP_BRAFLDRAFT_124759.1.1 m.36189 sp LRIQ3_MOUSE 46.154 234 126 0 56 289 14 247 8.58E-64 228 LRIQ3_MOUSE reviewed Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44) Lrriq3 Lrrc44 Mus musculus (Mouse) 633 0 0 0 0 0 PF12799; Q7Z4K8 CHOYP_TRI33.3.8 m.23933 sp TRI46_HUMAN 22.87 223 142 10 4 215 149 352 8.58E-07 52.8 TRI46_HUMAN reviewed "Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)" TRIM46 TRIFIC Homo sapiens (Human) 759 0 GO:0005622; GO:0008270 0 0 0 PF00643;PF13445; Q80X90 CHOYP_FLNA.1.6 m.11089 sp FLNB_MOUSE 26.297 1966 1239 66 22 1836 12 1918 8.58E-142 494 FLNB_MOUSE reviewed Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) Flnb Mus musculus (Mouse) 2602 actin cytoskeleton organization [GO:0030036]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; skeletal muscle tissue development [GO:0007519] GO:0001725; GO:0003334; GO:0003382; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0005938; GO:0007519; GO:0030018; GO:0030036; GO:0042802; GO:0044822; GO:0070062 0 0 0 PF00307;PF00630; Q8VHN7 CHOYP_LOC100891789.1.1 m.13946 sp GPR98_MOUSE 29.381 194 125 5 5 189 5663 5853 8.58E-20 90.9 GPR98_MOUSE reviewed G-protein coupled receptor 98 (Monogenic audiogenic seizure susceptibility protein 1) (Neurepin) (Very large G-protein coupled receptor 1) Gpr98 Kiaa0686 Mass1 Vlgr1 Mus musculus (Mouse) 6298 cell surface receptor signaling pathway [GO:0007166]; cellular response to calcium ion [GO:0071277]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; inner ear development [GO:0048839]; inner ear receptor stereocilium organization [GO:0060122]; maintenance of organ identity [GO:0048496]; nervous system development [GO:0007399]; neurological system process [GO:0050877]; photoreceptor cell maintenance [GO:0045494]; positive regulation of protein kinase A signaling [GO:0010739]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; single organismal cell-cell adhesion [GO:0016337]; visual perception [GO:0007601] GO:0002141; GO:0002142; GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0007166; GO:0007399; GO:0007601; GO:0007605; GO:0009986; GO:0010739; GO:0016020; GO:0016021; GO:0016337; GO:0017022; GO:0032391; GO:0043235; GO:0045184; GO:0045494; GO:0048471; GO:0048496; GO:0048839; GO:0050877; GO:0050910; GO:0050953; GO:0060122; GO:0070062; GO:0071277; GO:1990075; GO:1990696 0 0 0 PF00002;PF03160;PF03736; O00622 CHOYP_VWCE.1.3 m.5008 sp CYR61_HUMAN 32.456 114 64 4 344 447 97 207 8.59E-06 51.2 CYR61_HUMAN reviewed Protein CYR61 (CCN family member 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein GIG1) CYR61 CCN1 GIG1 IGFBP10 Homo sapiens (Human) 381 "anatomical structure morphogenesis [GO:0009653]; apoptotic process involved in heart morphogenesis [GO:0003278]; atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; cell proliferation [GO:0008283]; chemotaxis [GO:0006935]; chondroblast differentiation [GO:0060591]; chorio-allantoic fusion [GO:0060710]; extracellular matrix organization [GO:0030198]; intussusceptive angiogenesis [GO:0002041]; labyrinthine layer blood vessel development [GO:0060716]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell death [GO:0060548]; osteoblast differentiation [GO:0001649]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of phospholipase activity [GO:0010518]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; reactive oxygen species metabolic process [GO:0072593]; regulation of cell growth [GO:0001558]; regulation of ERK1 and ERK2 cascade [GO:0070372]; ventricular septum development [GO:0003281]; wound healing, spreading of cells [GO:0044319]" GO:0001558; GO:0001649; GO:0001934; GO:0002041; GO:0003181; GO:0003278; GO:0003281; GO:0005178; GO:0005578; GO:0006935; GO:0007155; GO:0007267; GO:0008201; GO:0008283; GO:0009653; GO:0010518; GO:0010811; GO:0030198; GO:0030335; GO:0030513; GO:0031012; GO:0033690; GO:0043066; GO:0043280; GO:0044319; GO:0045669; GO:0045860; GO:0045944; GO:0050840; GO:0060413; GO:0060548; GO:0060591; GO:0060710; GO:0060716; GO:0061036; GO:0070372; GO:0072593; GO:2000304 0 0 0 PF00007;PF00219;PF00093; O15050 CHOYP_LOC100661737.1.2 m.57972 sp TRNK1_HUMAN 43.636 110 61 1 745 854 783 891 8.59E-18 92.8 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 O15050 CHOYP_TRNK1.1.6 m.53445 sp TRNK1_HUMAN 26.587 583 325 18 1286 1777 450 1020 8.59E-37 157 TRNK1_HUMAN reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog) TRANK1 KIAA0342 LBA1 Homo sapiens (Human) 2925 0 GO:0005524 0 0 0 0 P02845 CHOYP_LOC100376142.1.1 m.18185 sp VIT2_CHICK 28.283 99 67 3 2 98 571 667 8.59E-08 51.6 VIT2_CHICK reviewed Vitellogenin-2 (Major vitellogenin) (Vitellogenin II) [Cleaved into: Lipovitellin-1 (Lipovitellin I) (LVI); Phosvitin (PV); Lipovitellin-2 (Lipovitellin II) (LVII); YGP40] VTG2 VTGII Gallus gallus (Chicken) 1850 0 GO:0005319; GO:0045735 0 0 0 PF09172;PF09175;PF01347;PF00094; P29691 CHOYP_LOC101242512.1.1 m.48609 sp EF2_CAEEL 85.149 101 15 0 1 101 363 463 8.59E-55 185 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P59382 CHOYP_BRAFLDRAFT_214694.1.1 m.26594 sp PXMP4_RAT 57.711 201 85 0 1 201 7 207 8.59E-85 252 PXMP4_RAT reviewed Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein) Pxmp4 Pmp24 Rattus norvegicus (Rat) 212 0 GO:0005778; GO:0016021 0 0 0 PF02466; Q96HI0 CHOYP_SENP5.1.1 m.62535 sp SENP5_HUMAN 28.369 141 71 4 59 184 573 698 8.59E-07 51.6 SENP5_HUMAN reviewed Sentrin-specific protease 5 (EC 3.4.22.68) (Sentrin/SUMO-specific protease SENP5) SENP5 FKSG45 Homo sapiens (Human) 755 cell cycle [GO:0007049]; cell division [GO:0051301]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925] GO:0004175; GO:0005634; GO:0005654; GO:0005730; GO:0007049; GO:0016925; GO:0016926; GO:0016929; GO:0043231; GO:0051301; GO:0070139 0 0 0 PF02902; Q9NP64 CHOYP_BRAFLDRAFT_261238.1.1 m.43629 sp NO40_HUMAN 47.647 170 77 2 24 181 10 179 8.59E-44 150 NO40_HUMAN reviewed Nucleolar protein of 40 kDa (pNO40) (Pnn-interacting nucleolar protein) (Putative S1 RNA-binding domain protein) (PS1D protein) (Zinc finger CCHC domain-containing protein 17) ZCCHC17 PS1D HSPC243 HSPC251 LDC4 Homo sapiens (Human) 241 mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; xenophagy [GO:0098792] GO:0002230; GO:0005634; GO:0005730; GO:0008270; GO:0030529; GO:0043231; GO:0044822; GO:0045111; GO:0098779; GO:0098792 0 0 0 PF00575; Q9QX47 CHOYP_LOC100542052.1.2 m.19977 sp SON_MOUSE 58.491 106 44 0 3 108 2330 2435 8.59E-41 147 SON_MOUSE reviewed Protein SON (Negative regulatory element-binding protein) (NRE-binding protein) Son Nrebp Mus musculus (Mouse) 2444 "microtubule cytoskeleton organization [GO:0000226]; mitotic cytokinesis [GO:0000281]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of RNA splicing [GO:0043484]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000226; GO:0000281; GO:0003677; GO:0003723; GO:0005654; GO:0006351; GO:0006355; GO:0006397; GO:0008380; GO:0016607; GO:0043066; GO:0043484; GO:0044822; GO:0048024; GO:0050733; GO:0051726; GO:0071011 0 0 0 PF01585; O75575 CHOYP_CRCP.1.1 m.26675 sp RPC9_HUMAN 56.061 132 55 1 1 129 1 132 8.60E-35 120 RPC9_HUMAN reviewed DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) CRCP Homo sapiens (Human) 148 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuropeptide signaling pathway [GO:0007218]; positive regulation of type I interferon production [GO:0032481]; transcription from RNA polymerase III promoter [GO:0006383]; transcription initiation from RNA polymerase III promoter [GO:0006384] GO:0000166; GO:0001635; GO:0001669; GO:0003899; GO:0005654; GO:0005666; GO:0005829; GO:0005886; GO:0006383; GO:0006384; GO:0007218; GO:0009360; GO:0032481; GO:0045087; GO:0051607 0 0 0 PF03874; O94759 CHOYP_TRPM2.5.12 m.34628 sp TRPM2_HUMAN 25.509 639 382 17 407 983 483 1089 8.60E-42 171 TRPM2_HUMAN reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) TRPM2 EREG1 KNP3 LTRPC2 TRPC7 Homo sapiens (Human) 1503 calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; estrous cycle [GO:0044849]; positive regulation of insulin secretion [GO:0032024]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; response to oxidative stress [GO:0006979] GO:0005262; GO:0005272; GO:0005622; GO:0005886; GO:0005887; GO:0006816; GO:0006979; GO:0032024; GO:0043005; GO:0043025; GO:0044849; GO:0047631; GO:0070588; GO:0098703; GO:1903223 0 0 0 PF00520; O96006 CHOYP_ZBED1.1.2 m.17695 sp ZBED1_HUMAN 30.994 171 99 6 33 190 4 168 8.60E-12 67 ZBED1_HUMAN reviewed Zinc finger BED domain-containing protein 1 (Putative Ac-like transposable element) (dREF homolog) ZBED1 ALTE DREF KIAA0785 TRAMP Homo sapiens (Human) 694 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000228; GO:0000977; GO:0003700; GO:0004803; GO:0005634; GO:0005737; GO:0006357; GO:0015629; GO:0046872 0 0 0 PF05699;PF02892; Q29611 CHOYP_DANA_GF25236.1.1 m.38005 sp CLN3_CANLF 43.318 217 122 1 1 216 216 432 8.60E-60 196 CLN3_CANLF reviewed Battenin (Protein CLN3) CLN3 Canis lupus familiaris (Dog) (Canis familiaris) 438 amyloid precursor protein catabolic process [GO:0042987]; arginine transport [GO:0015809]; ceramide metabolic process [GO:0006672]; galactosylceramide metabolic process [GO:0006681]; globoside metabolic process [GO:0001575]; glucosylceramide metabolic process [GO:0006678]; lysosomal lumen acidification [GO:0007042]; lysosomal lumen pH elevation [GO:0035752]; negative regulation of apoptotic process [GO:0043066]; receptor-mediated endocytosis [GO:0006898]; sphingomyelin metabolic process [GO:0006684]; vacuolar transport [GO:0007034]; vesicle transport along microtubule [GO:0047496] GO:0000139; GO:0001575; GO:0005634; GO:0005737; GO:0005764; GO:0005765; GO:0005769; GO:0005770; GO:0005783; GO:0005794; GO:0005795; GO:0005802; GO:0005886; GO:0005901; GO:0006672; GO:0006678; GO:0006681; GO:0006684; GO:0006898; GO:0007034; GO:0007042; GO:0008021; GO:0015809; GO:0016021; GO:0030176; GO:0031301; GO:0035752; GO:0042987; GO:0043005; GO:0043066; GO:0045121; GO:0047496 0 0 0 PF02487; Q3SZW1 CHOYP_LOC100370380.1.1 m.49423 sp TSSK1_BOVIN 55.442 294 125 2 22 309 2 295 8.60E-108 321 TSSK1_BOVIN reviewed Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) TSSK1B TSSK1 Bos taurus (Bovine) 367 intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286] GO:0001669; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007275; GO:0007286; GO:0031514; GO:0035556; GO:0046872 0 0 0 PF00069; Q6V0I7 CHOYP_LOC100366669.1.1 m.62059 sp FAT4_HUMAN 53.247 77 36 0 120 196 3859 3935 8.60E-21 97.4 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q9D361 CHOYP_SNR48.1.1 m.8120 sp SNR48_MOUSE 30.571 350 194 11 8 341 11 327 8.60E-30 120 SNR48_MOUSE reviewed U11/U12 small nuclear ribonucleoprotein 48 kDa protein (U11/U12 snRNP 48 kDa protein) Snrnp48 Mus musculus (Mouse) 337 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0005654; GO:0005689; GO:0005737; GO:0006397; GO:0008380; GO:0046872 0 0 0 PF05253; Q9R1R2 CHOYP_TRIM3.39.58 m.39434 sp TRIM3_MOUSE 25.455 275 169 13 299 553 486 744 8.60E-13 74.7 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; Q9VKJ9 CHOYP_C2D1.1.1 m.8807 sp C2D1_DROME 39.836 856 455 19 1 837 1 815 8.60E-173 527 C2D1_DROME reviewed Coiled-coil and C2 domain-containing protein 1-like (Lethal giant disks protein) l(2)gd1 lgd CG4713 Drosophila melanogaster (Fruit fly) 816 compound eye development [GO:0048749]; endosomal transport [GO:0016197]; female germ-line stem cell asymmetric division [GO:0048132]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; multivesicular body organization [GO:0036257]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of protein catabolic process [GO:0045732]; regulation of endocytosis [GO:0030100]; regulation of Notch signaling pathway [GO:0008593]; sensory organ development [GO:0007423]; sensory organ precursor cell division [GO:0045035]; wing disc morphogenesis [GO:0007472] GO:0000122; GO:0000281; GO:0000981; GO:0005543; GO:0005634; GO:0005737; GO:0006886; GO:0007219; GO:0007423; GO:0007472; GO:0008586; GO:0008593; GO:0016197; GO:0016324; GO:0030100; GO:0036257; GO:0045035; GO:0045732; GO:0045746; GO:0048132; GO:0048749 0 0 0 PF00168; A8E657 CHOYP_DPSE_GA20134.1.2 m.50847 sp AASS_BOVIN 66.279 172 58 0 31 202 25 196 8.61E-75 244 AASS_BOVIN reviewed "Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]" AASS Bos taurus (Bovine) 926 L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512] GO:0005739; GO:0033512; GO:0047130; GO:0047131 PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.; PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6. 0 0 PF05222;PF16653;PF03435; O14522 CHOYP_PTPRC.7.14 m.40520 sp PTPRT_HUMAN 29.89 726 427 22 280 955 718 1411 8.61E-72 263 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O22558 CHOYP_BRAFLDRAFT_81321.7.10 m.52965 sp STY8_ARATH 29.94 167 103 6 845 1005 378 536 8.61E-16 85.5 STY8_ARATH reviewed Serine/threonine-protein kinase STY8 (EC 2.7.11.1) (Serine/threonine/tyrosine-protein kinase 8) STY8 At2g17700 Arabidopsis thaliana (Mouse-ear cress) 546 chloroplast organization [GO:0009658] GO:0004674; GO:0004712; GO:0005524; GO:0005829; GO:0009658; GO:0016597 0 0 0 PF07714; P10079 CHOYP_LOC100634060.33.37 m.65879 sp FBP1_STRPU 54.601 326 148 0 1 326 240 565 8.61E-108 340 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; Q2PC93 CHOYP_LOC100648399.1.1 m.3148 sp SSPO_CHICK 29.661 236 119 10 89 318 1548 1742 8.61E-10 64.7 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q2PFD7 CHOYP_LOC100864134.1.1 m.41690 sp PSD3_MOUSE 53.448 406 179 3 348 743 573 978 8.61E-139 440 PSD3_MOUSE reviewed PH and SEC7 domain-containing protein 3 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Pleckstrin homology and SEC7 domain-containing protein 3) Psd3 Efa6d Kiaa0942 Mus musculus (Mouse) 1037 ARF protein signal transduction [GO:0032011]; regulation of ARF protein signal transduction [GO:0032012] GO:0005086; GO:0014069; GO:0016020; GO:0030054; GO:0032011; GO:0032012; GO:0045211 0 0 0 PF01369; Q5BIM1 CHOYP_TRIM45.1.9 m.10742 sp TRI45_BOVIN 32.653 98 60 4 4 97 127 222 8.61E-06 47.4 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q90YS0 CHOYP_LOC100198506.1.1 m.20806 sp RS4_ICTPU 71.042 259 75 0 1 259 1 259 8.61E-142 401 RS4_ICTPU reviewed 40S ribosomal protein S4 rps4 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 263 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q9H0A8 CHOYP_BRAFLDRAFT_116088.1.2 m.13623 sp COMD4_HUMAN 60 185 74 0 1 185 1 185 8.61E-82 244 COMD4_HUMAN reviewed COMM domain-containing protein 4 COMMD4 Homo sapiens (Human) 199 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355 0 0 0 PF07258; Q9HAC7 CHOYP_LOC101160363.1.1 m.194 sp SUCHY_HUMAN 57.531 405 168 1 34 438 39 439 8.61E-174 497 SUCHY_HUMAN reviewed Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13) (SuccinylCoA:glutarate-CoA transferase) SUGCT C7orf10 DERP13 Homo sapiens (Human) 445 0 GO:0005739; GO:0047369 0 0 0 PF02515; Q9R172 CHOYP_BRAFLDRAFT_64392.1.2 m.4268 sp NOTC3_RAT 28.662 157 85 7 530 664 1085 1236 8.61E-12 72.8 NOTC3_RAT reviewed Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] Notch3 Rattus norvegicus (Rat) 2319 "cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; Notch signaling pathway [GO:0007219]; regulation of transcription, DNA-templated [GO:0006355]; tissue regeneration [GO:0042246]; transcription, DNA-templated [GO:0006351]" GO:0004872; GO:0005509; GO:0005634; GO:0005886; GO:0006351; GO:0006355; GO:0007219; GO:0007275; GO:0016021; GO:0030154; GO:0042246 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.14.15 m.61843 sp MLRP2_ACRMI 26.765 1289 760 57 1712 2895 889 2098 8.62E-82 307 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; Q0VC33 CHOYP_TSN11.1.1 m.41938 sp TSN11_BOVIN 26.996 263 158 8 27 288 17 246 8.62E-18 84 TSN11_BOVIN reviewed Tetraspanin-11 (Tspan-11) TSPAN11 Bos taurus (Bovine) 253 cell surface receptor signaling pathway [GO:0007166] GO:0005887; GO:0007166 0 0 0 PF00335; Q2KMM2 CHOYP_DENND4A.1.1 m.344 sp TPPC1_RAT 60.14 143 57 0 6 148 1 143 8.62E-67 202 TPPC1_RAT reviewed Trafficking protein particle complex subunit 1 Trappc1 Rattus norvegicus (Rat) 145 ER to Golgi vesicle-mediated transport [GO:0006888] GO:0005783; GO:0005794; GO:0006888; GO:0017112; GO:0030008 0 0 0 PF04099; Q2TBL4 CHOYP_RPC3.3.3 m.18603 sp RPC3_BOVIN 42.105 304 155 8 6 294 35 332 8.62E-72 233 RPC3_BOVIN reviewed DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) POLR3C Bos taurus (Bovine) 533 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription from RNA polymerase III promoter [GO:0006383] GO:0003677; GO:0003899; GO:0005666; GO:0006383; GO:0032728; GO:0045087; GO:0045089; GO:0051607 0 0 0 PF08221;PF05645; Q460N5 CHOYP_LOC100928016.4.6 m.48759 sp PAR14_HUMAN 35.196 179 111 3 230 406 798 973 8.62E-26 115 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5ZJL9 CHOYP_LOC101162528.1.1 m.17841 sp SAMH1_CHICK 38.735 506 230 9 5 495 107 547 8.62E-103 325 SAMH1_CHICK reviewed Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) SAMHD1 RCJMB04_17d8 Gallus gallus (Chicken) 614 dATP catabolic process [GO:0046061]; defense response to virus [GO:0051607]; dGTP catabolic process [GO:0006203]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088] GO:0003676; GO:0003723; GO:0005634; GO:0006203; GO:0008270; GO:0008832; GO:0032567; GO:0045087; GO:0045088; GO:0046061; GO:0051607 0 0 0 PF01966; Q6DHC1 CHOYP_RB18B.1.1 m.14959 sp RB18B_DANRE 77.941 204 42 2 4 204 2 205 8.62E-115 328 RB18B_DANRE reviewed Ras-related protein Rab-18-B rab18b rab18 zgc:92523 Danio rerio (Zebrafish) (Brachydanio rerio) 205 brain development [GO:0007420]; chordate embryonic development [GO:0043009]; eye development [GO:0001654]; lipid particle organization [GO:0034389]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264] GO:0001654; GO:0005525; GO:0005622; GO:0007264; GO:0007420; GO:0015031; GO:0034389; GO:0043009 0 0 0 PF00071; Q80T91 CHOYP_BRAFLDRAFT_224574.16.18 m.51002 sp MEG11_MOUSE 35.422 367 195 17 1 342 499 848 8.62E-38 148 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8C8U0 CHOYP_PPFIBP1.1.1 m.56008 sp LIPB1_MOUSE 40.564 816 360 21 207 908 149 953 8.62E-174 532 LIPB1_MOUSE reviewed Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) Ppfibp1 Kiaa1230 Mus musculus (Mouse) 969 0 GO:0005925 0 0 0 PF00536;PF07647; Q969J3 CHOYP_LOC100369026.1.1 m.15848 sp BORC5_HUMAN 42.162 185 101 3 54 233 6 189 8.62E-44 149 BORC5_HUMAN reviewed BLOC-1-related complex subunit 5 (Loss of heterozygosity 12 chromosomal region 1) (Myristoylated lysosomal protein) (Myrlysin) BORCS5 LOH12CR1 Homo sapiens (Human) 196 lysosome localization [GO:0032418]; organelle transport along microtubule [GO:0072384] GO:0031224; GO:0032418; GO:0043234; GO:0072384; GO:0098574 0 0 0 PF10158; Q9NRL2 CHOYP_BRAFLDRAFT_216893.1.1 m.18938 sp BAZ1A_HUMAN 33.728 507 210 12 1 478 789 1198 8.62E-70 249 BAZ1A_HUMAN reviewed Bromodomain adjacent to zinc finger domain protein 1A (ATP-dependent chromatin-remodeling protein) (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (CHRAC subunit ACF1) (Williams syndrome transcription factor-related chromatin-remodeling factor 180) (WCRF180) (hWALp1) BAZ1A ACF1 WCRF180 HSPC317 Homo sapiens (Human) 1556 "chromatin remodeling [GO:0006338]; DNA-dependent DNA replication [GO:0006261]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006261; GO:0006338; GO:0006351; GO:0006355; GO:0008270; GO:0008623; GO:0016590 0 0 0 PF00439;PF02791;PF00628;PF10537;PF15612;PF15613; Q9ULJ7 CHOYP_TVAG_466020.1.1 m.6873 sp ANR50_HUMAN 35.455 110 71 0 26 135 965 1074 8.62E-13 73.2 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; P43679 CHOYP_BRAFLDRAFT_220220.1.1 m.32334 sp ACHB3_CHICK 31.928 166 101 3 1 159 152 312 8.63E-19 88.2 ACHB3_CHICK reviewed Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Gallus gallus (Chicken) 455 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; Q27J81 CHOYP_INF2.1.5 m.64 sp INF2_HUMAN 33.042 457 272 10 535 974 560 999 8.63E-58 220 INF2_HUMAN reviewed Inverted formin-2 (HBEBP2-binding protein C) INF2 C14orf151 C14orf173 Homo sapiens (Human) 1249 actin cytoskeleton organization [GO:0030036]; regulation of mitochondrial fission [GO:0090140] GO:0030036; GO:0048471; GO:0090140 0 0 0 PF06367;PF06371;PF02181;PF02205; Q502M6 CHOYP_LOC578974.7.11 m.39667 sp ANR29_DANRE 43.81 105 59 0 1 105 116 220 8.63E-23 92.8 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q99020 CHOYP_ACO1.1.1 m.40518 sp ROAA_MOUSE 60 55 22 0 53 107 70 124 8.63E-16 73.9 ROAA_MOUSE reviewed Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (CArG-binding factor-A) (CBF-A) Hnrnpab Cbf-a Cgbfa Hnrpab Mus musculus (Mouse) 285 "epithelial to mesenchymal transition [GO:0001837]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0001837; GO:0003677; GO:0003723; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0030529; GO:0044822; GO:0045893; GO:0090575 0 0 0 PF08143;PF00076; Q9MYM7 CHOYP_LOC571003.1.1 m.32136 sp B3GT1_PONPY 32.685 257 165 6 60 312 68 320 8.63E-43 153 B3GT1_PONPY reviewed "Beta-1,3-galactosyltransferase 1 (Beta-1,3-GalTase 1) (Beta3Gal-T1) (Beta3GalT1) (EC 2.4.1.-) (UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1)" B3GALT1 Pongo pygmaeus (Bornean orangutan) 326 protein glycosylation [GO:0006486] GO:0000139; GO:0006486; GO:0008378; GO:0016021 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q9NXG6 CHOYP_BRAFLDRAFT_126352.1.2 m.49948 sp P4HTM_HUMAN 33.559 295 180 7 5 288 177 466 8.63E-50 175 P4HTM_HUMAN reviewed Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4) P4HTM PH4 Homo sapiens (Human) 502 regulation of erythrocyte differentiation [GO:0045646] GO:0005506; GO:0005509; GO:0005789; GO:0016021; GO:0016706; GO:0031418; GO:0045646 0 0 0 PF13640;PF13499; O88281 CHOYP_MEGF6.15.59 m.24311 sp MEGF6_RAT 30.556 1008 548 39 184 1122 601 1525 8.64E-80 291 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; Q03348 CHOYP_PTPRA.10.22 m.47416 sp PTPRA_RAT 29.429 666 427 18 37 675 142 791 8.64E-79 271 PTPRA_RAT reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Ptpra Lrp Rattus norvegicus (Rat) 796 oligodendrocyte differentiation [GO:0048709]; positive regulation of oligodendrocyte differentiation [GO:0048714] GO:0004725; GO:0005886; GO:0016021; GO:0032403; GO:0043231; GO:0048709; GO:0048714 0 0 0 PF00102; Q14980 CHOYP_TVAG_110290.2.8 m.6221 sp NUMA1_HUMAN 24.402 627 290 26 1744 2231 1476 2057 8.64E-13 78.6 NUMA1_HUMAN reviewed Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen) NUMA1 NMP22 NUMA Homo sapiens (Human) 2115 cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997] GO:0000132; GO:0000139; GO:0000922; GO:0005198; GO:0005634; GO:0005654; GO:0005694; GO:0005737; GO:0005813; GO:0005819; GO:0005829; GO:0005876; GO:0005938; GO:0006997; GO:0007067; GO:0016363; GO:0030425; GO:0043025; GO:0045177; GO:0051301; GO:0051321; GO:0060487; GO:0061673; GO:0070062; GO:0072686; GO:0097431 0 0 0 0 Q28CA0 CHOYP_PITC1.1.1 m.23259 sp PITC1_XENTR 77.895 95 21 0 1 95 1 95 8.64E-52 169 PITC1_XENTR reviewed Cytoplasmic phosphatidylinositol transfer protein 1 (Retinal degeneration B homolog beta) (RdgBbeta) pitpnc1 TGas018n09.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 329 signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0008289; GO:0008526 0 0 0 PF02121; Q2YDS5 CHOYP_SCNM1.1.1 m.13948 sp SCNM1_DANRE 52.083 96 46 0 1 96 1 96 8.64E-26 107 SCNM1_DANRE reviewed Sodium channel modifier 1 scnm1 zgc:123015 Danio rerio (Zebrafish) (Brachydanio rerio) 249 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0006397; GO:0008380; GO:0016607; GO:0046872 0 0 0 PF15805;PF15803; Q5NVR0 CHOYP_BRAFLDRAFT_278614.1.2 m.17368 sp HMCES_PONAB 36.436 376 160 8 1 368 1 305 8.64E-75 239 HMCES_PONAB reviewed Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein (ES cell-specific 5hmC-binding protein) (Putative peptidase SRAPD1) (EC 3.4.-.-) (SRAP domain-containing protein 1) HMCES SRAPD1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 354 0 GO:0003677; GO:0008233 0 0 0 PF02586; Q66IV1 CHOYP_LOC100368674.1.1 m.6085 sp MRF_XENLA 44.76 668 287 11 207 850 270 879 8.64E-173 531 MRF_XENLA reviewed "Myelin regulatory factor (EC 3.4.-.-) (Myelin gene regulatory factor) [Cleaved into: Myelin regulatory factor, N-terminal; Myelin regulatory factor, C-terminal]" myrf mrf Xenopus laevis (African clawed frog) 1092 "central nervous system myelination [GO:0022010]; central nervous system myelin maintenance [GO:0032286]; oligodendrocyte development [GO:0014003]; oligodendrocyte differentiation [GO:0048709]; positive regulation of myelination [GO:0031643]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0005789; GO:0006351; GO:0008233; GO:0014003; GO:0016021; GO:0022010; GO:0031643; GO:0032286; GO:0045893; GO:0048709 0 0 0 PF13887;PF13888;PF05224;PF13884; Q8C0W1 CHOYP_LOC100375760.1.1 m.50645 sp ANMY1_MOUSE 52.174 46 22 0 23 68 840 885 8.64E-12 65.1 ANMY1_MOUSE reviewed Ankyrin repeat and MYND domain-containing protein 1 Ankmy1 Mus musculus (Mouse) 906 0 GO:0046872 0 0 0 PF12796;PF02493;PF01753; Q8N6F8 CHOYP_NEMVEDRAFT_V1G245969.2.2 m.28813 sp WBS27_HUMAN 29.268 205 136 4 1 205 1 196 8.64E-26 103 WBS27_HUMAN reviewed Williams-Beuren syndrome chromosomal region 27 protein WBSCR27 Homo sapiens (Human) 245 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259 0 0 0 0 Q8VBT9 CHOYP_NEMVEDRAFT_V1G236653.1.1 m.59422 sp ASPC1_MOUSE 39.344 183 107 2 258 437 315 496 8.64E-37 145 ASPC1_MOUSE reviewed Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein homolog) Aspscr1 Tug Mus musculus (Mouse) 550 glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; regulation of glucose import [GO:0046324] GO:0005654; GO:0005829; GO:0005886; GO:0006886; GO:0009898; GO:0012505; GO:0012506; GO:0019898; GO:0030659; GO:0033116; GO:0042593; GO:0043231; GO:0046324; GO:0048471; GO:0061024 0 0 0 PF11470;PF00789; Q920R0 CHOYP_ALS2.2.3 m.37863 sp ALS2_MOUSE 54.745 137 61 1 1 136 1514 1650 8.64E-46 162 ALS2_MOUSE reviewed Alsin (Amyotrophic lateral sclerosis 2 protein homolog) Als2 Mus musculus (Mouse) 1651 "axonogenesis [GO:0007409]; behavioral fear response [GO:0001662]; cell death [GO:0008219]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; in utero embryonic development [GO:0001701]; locomotory behavior [GO:0007626]; lysosomal transport [GO:0007041]; neuromuscular junction development [GO:0007528]; neuron projection morphogenesis [GO:0048812]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; protein homooligomerization [GO:0051260]; protein localization [GO:0008104]; Rac protein signal transduction [GO:0016601]; receptor recycling [GO:0001881]; regulation of endosome size [GO:0051036]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; response to oxidative stress [GO:0006979]; synaptic transmission, glutamatergic [GO:0035249]; vesicle organization [GO:0016050]" GO:0001662; GO:0001701; GO:0001726; GO:0001881; GO:0005096; GO:0005634; GO:0005737; GO:0005769; GO:0005813; GO:0005829; GO:0006979; GO:0007032; GO:0007041; GO:0007409; GO:0007528; GO:0007626; GO:0008104; GO:0008219; GO:0014069; GO:0016020; GO:0016050; GO:0016197; GO:0016601; GO:0017112; GO:0017137; GO:0030027; GO:0030424; GO:0030425; GO:0030426; GO:0030676; GO:0031982; GO:0035023; GO:0035249; GO:0042802; GO:0042803; GO:0043025; GO:0043087; GO:0043197; GO:0043234; GO:0043539; GO:0043547; GO:0045860; GO:0048365; GO:0048812; GO:0051036; GO:0051260 0 0 0 PF02493;PF00415;PF00621;PF02204; Q95PA1 CHOYP_SMP_050220.1.1 m.37745 sp CPLX_DORPE 61.111 162 52 4 1 161 1 152 8.64E-27 101 CPLX_DORPE reviewed Complexin (Synaphin) cpx Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 152 exocytosis [GO:0006887]; neurotransmitter transport [GO:0006836] GO:0005829; GO:0006836; GO:0006887; GO:0016020 0 0 0 PF05835; A2BFP5 CHOYP_contig_011548 m.13287 sp S12A9_DANRE 50 56 24 1 57 108 21 76 8.65E-09 54.7 S12A9_DANRE reviewed Solute carrier family 12 member 9 slc12a9 si:ch211-284e13.1 Danio rerio (Zebrafish) (Brachydanio rerio) 899 0 GO:0005886; GO:0015379; GO:0016021; GO:0022820 0 0 0 PF00324;PF03522; O74745 CHOYP_MGYG_01774.1.1 m.9448 sp ANP1_SCHPO 32.824 262 155 8 156 399 100 358 8.65E-32 128 ANP1_SCHPO reviewed Mannan polymerase II complex anp1 subunit (M-Pol II subunit anp1) anp1 SPBC1734.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 430 0 GO:0000137; GO:0000139; GO:0005783; GO:0005789; GO:0005794; GO:0016021 0 0 0 0 P16157 CHOYP_TVAG_470020.6.8 m.25023 sp ANK1_HUMAN 32.805 442 273 5 42 466 111 545 8.65E-59 213 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q0VCS9 CHOYP_ANKMY2.1.1 m.18238 sp ANKY2_BOVIN 49.02 408 190 5 55 444 30 437 8.65E-132 390 ANKY2_BOVIN reviewed Ankyrin repeat and MYND domain-containing protein 2 ANKMY2 Bos taurus (Bovine) 442 0 GO:0005929; GO:0046872 0 0 0 PF12796;PF01753; Q13492 CHOYP_PICAL.1.1 m.45487 sp PICAL_HUMAN 39.535 473 204 15 3 414 186 637 8.65E-86 279 PICAL_HUMAN reviewed Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) PICALM CALM Homo sapiens (Human) 652 "cargo loading into vesicle [GO:0035459]; cell proliferation [GO:0008283]; clathrin coat assembly [GO:0048268]; clathrin-mediated endocytosis [GO:0072583]; endosomal transport [GO:0016197]; iron ion homeostasis [GO:0055072]; iron ion import into cell [GO:0097459]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of beta-amyloid formation [GO:1902004]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription, DNA-templated [GO:0045893]; protein complex assembly [GO:0006461]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; synaptic vesicle maturation [GO:0016188]; vesicle-mediated transport [GO:0016192]" GO:0005545; GO:0005634; GO:0005794; GO:0005905; GO:0005913; GO:0006461; GO:0006898; GO:0008283; GO:0010629; GO:0016020; GO:0016188; GO:0016192; GO:0016197; GO:0030100; GO:0030136; GO:0030276; GO:0031623; GO:0031982; GO:0032050; GO:0032880; GO:0035459; GO:0035615; GO:0042734; GO:0043025; GO:0045211; GO:0045893; GO:0048261; GO:0048268; GO:0055072; GO:0072583; GO:0097418; GO:0097459; GO:0098641; GO:1901216; GO:1902004; GO:1902959; GO:1902961; GO:1902963 0 0 0 PF07651; Q4R866 CHOYP_BRAFLDRAFT_242472.1.1 m.7222 sp SC22A_MACFA 38.158 304 181 3 8 311 9 305 8.65E-66 211 SC22A_MACFA reviewed Vesicle-trafficking protein SEC22a (SEC22 vesicle-trafficking protein homolog A) SEC22A QtsA-13287 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 307 protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0005789; GO:0015031; GO:0016021; GO:0016192 0 0 0 PF13774; Q54IT3 CHOYP_SMP_012720.2.2 m.34967 sp AOFA_DICDI 34.348 460 282 7 48 505 6 447 8.65E-90 287 AOFA_DICDI reviewed Probable flavin-containing monoamine oxidase A (EC 1.4.3.4) maoA DDB_G0288541 Dictyostelium discoideum (Slime mold) 456 0 GO:0016491 0 0 0 PF01593; Q5EAN7 CHOYP_LOC763087.1.1 m.9110 sp TE2IP_RAT 31.22 205 121 7 2 196 13 207 8.65E-15 80.5 TE2IP_RAT reviewed Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Repressor/activator protein 1 homolog) (RAP1 homolog) Terf2ip Rap1 Rattus norvegicus (Rat) 393 "negative regulation of DNA recombination at telomere [GO:0048239]; negative regulation of telomere maintenance [GO:0032205]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein acetylation [GO:1901985]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of transcription, DNA-templated [GO:0006355]; telomere maintenance via telomere lengthening [GO:0010833]; transcription, DNA-templated [GO:0006351]" GO:0000781; GO:0005634; GO:0005635; GO:0005737; GO:0006351; GO:0006355; GO:0010569; GO:0010833; GO:0030870; GO:0032205; GO:0033138; GO:0042162; GO:0043123; GO:0048239; GO:0051092; GO:0070187; GO:0070198; GO:1901985 0 0 0 PF16589;PF08914;PF11626; Q66K08 CHOYP_CILP1.1.1 m.4616 sp CILP1_MOUSE 25.118 1059 646 37 34 1035 152 1120 8.65E-75 272 CILP1_MOUSE reviewed Cartilage intermediate layer protein 1 (CILP-1) [Cleaved into: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2] Cilp Mus musculus (Mouse) 1184 negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569] GO:0005578; GO:0005615; GO:0031012; GO:0043569; GO:0070062 0 0 0 PF13330;PF00090; Q6PFY8 CHOYP_LOC100378898.2.10 m.21484 sp TRI45_MOUSE 28.922 204 128 6 8 205 129 321 8.65E-13 73.6 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9CQE2 CHOYP_AAEL_AAEL007423.1.1 m.645 sp TM223_MOUSE 36.782 87 52 2 198 284 116 199 8.65E-06 48.9 TM223_MOUSE reviewed Transmembrane protein 223 Tmem223 Mus musculus (Mouse) 199 nervous system development [GO:0007399] GO:0005739; GO:0007399; GO:0016021 0 0 0 0 A4FVI0 CHOYP_BUP1.1.1 m.13642 sp ZSWM7_DANRE 45.865 133 72 0 5 137 2 134 8.66E-40 133 ZSWM7_DANRE reviewed Zinc finger SWIM domain-containing protein 7 zswim7 si:ch211-31p3.2 Danio rerio (Zebrafish) (Brachydanio rerio) 140 double-strand break repair via homologous recombination [GO:0000724] GO:0000724; GO:0005634; GO:0008270 0 0 0 PF04434; O35930 CHOYP_PFB0775W.1.3 m.46691 sp GP1BA_MOUSE 45.614 114 62 0 16 129 404 517 8.66E-06 51.6 GP1BA_MOUSE reviewed Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (CD antigen CD42b) Gp1ba Mus musculus (Mouse) 734 blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cell morphogenesis [GO:0000902]; cytokine-mediated signaling pathway [GO:0019221]; fibrinolysis [GO:0042730]; hemostasis [GO:0007599]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469] GO:0000902; GO:0004860; GO:0005737; GO:0005886; GO:0005887; GO:0006469; GO:0007155; GO:0007596; GO:0007599; GO:0009986; GO:0016020; GO:0019221; GO:0031362; GO:0042730; GO:0046426; GO:0070062 0 0 0 PF13855; P04352 CHOYP_CML25.1.1 m.23475 sp CALM_CHLRE 36.601 153 96 1 5 157 1 152 8.66E-28 104 CALM_CHLRE reviewed Calmodulin (CaM) 0 Chlamydomonas reinhardtii (Chlamydomonas smithii) 163 0 GO:0005509 0 0 0 PF13499; P04352 CHOYP_DHRS1.1.1 m.57313 sp CALM_CHLRE 36.601 153 96 1 5 157 1 152 8.66E-28 104 CALM_CHLRE reviewed Calmodulin (CaM) 0 Chlamydomonas reinhardtii (Chlamydomonas smithii) 163 0 GO:0005509 0 0 0 PF13499; P11928 CHOYP_OAS1A.1.1 m.5587 sp OAS1A_MOUSE 32.836 335 185 12 77 375 4 334 8.66E-38 142 OAS1A_MOUSE reviewed 2'-5'-oligoadenylate synthase 1A ((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (EC 2.7.7.84) (p42 OAS) Oas1a Oias1 Mus musculus (Mouse) 367 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral process [GO:0048525]; purine nucleotide biosynthetic process [GO:0006164]; response to virus [GO:0009615] GO:0001730; GO:0003725; GO:0005524; GO:0005634; GO:0005739; GO:0005783; GO:0006164; GO:0009615; GO:0045087; GO:0046872; GO:0048525; GO:0051607 0 0 0 PF01909;PF10421; P16157 CHOYP_AFUA_1G01020.29.50 m.39019 sp ANK1_HUMAN 35.788 584 371 2 5 588 32 611 8.66E-88 301 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P40983 CHOYP_TRIADDRAFT_54954.1.1 m.55021 sp YOR6_CALSR 27.848 237 131 8 88 317 15 218 8.66E-09 62 YOR6_CALSR reviewed Uncharacterized protein in xynA 3'region (ORF6) (Fragment) 0 Caldicellulosiruptor sp. (strain Rt8B.4) 402 0 0 0 0 0 PF00350; Q04202 CHOYP_contig_021543 m.24758 sp TCB2_CAEBR 37.209 86 52 1 32 117 126 209 8.66E-11 60.1 TCB2_CAEBR reviewed Transposable element Tcb2 transposase 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; Q1LVC2 CHOYP_AGAP_AGAP005541.1.1 m.16241 sp JARD2_DANRE 31 200 102 4 24 219 5 172 8.66E-14 80.5 JARD2_DANRE reviewed Protein Jumonji (Jumonji/ARID domain-containing protein 2) jarid2b jmj si:dkey-211c3.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1319 "covalent chromatin modification [GO:0016569]; multicellular organism development [GO:0007275]; negative regulation of histone methylation [GO:0031061]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of histone H3-K9 methylation [GO:0051574]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003682; GO:0005634; GO:0006351; GO:0007275; GO:0016569; GO:0031061; GO:0035097; GO:0045892; GO:0048863; GO:0051574 0 0 0 PF01388;PF02373;PF02375;PF02928; Q32LE4 CHOYP_LOC100703332.1.1 m.48867 sp GGCT_BOVIN 41.011 178 94 3 2 175 13 183 8.66E-41 139 GGCT_BOVIN reviewed Gamma-glutamylcyclotransferase (EC 2.3.2.4) GGCT Bos taurus (Bovine) 188 glutathione biosynthetic process [GO:0006750]; release of cytochrome c from mitochondria [GO:0001836] GO:0001836; GO:0003839; GO:0005829; GO:0006750; GO:0042803 0 0 cd06661; 0 Q5SFM8 CHOYP_LOC100565366.1.1 m.49990 sp RBM27_MOUSE 31.034 580 290 16 382 910 476 996 8.66E-55 211 RBM27_MOUSE reviewed RNA-binding protein 27 (Peri-implantation stem cell protein 1) (RNA-binding motif protein 27) Rbm27 Kiaa1311 Mus musculus (Mouse) 1060 mRNA processing [GO:0006397] GO:0000166; GO:0005737; GO:0006397; GO:0016607; GO:0044822; GO:0046872 0 0 0 PF01480;PF00642; Q6ZQ12 CHOYP_LOC583607.3.4 m.30972 sp NINL_MOUSE 33.962 318 196 8 47 360 292 599 8.66E-35 148 NINL_MOUSE reviewed Ninein-like protein Ninl Kiaa0980 Nlp Mus musculus (Mouse) 1394 microtubule cytoskeleton organization [GO:0000226] GO:0000226; GO:0005509; GO:0005737; GO:0005815; GO:0005856; GO:0005874 0 0 0 PF13499; Q7JVE7 CHOYP_LOC663546.1.1 m.14823 sp SWET1_DROME 38.86 193 115 3 15 205 17 208 8.66E-42 144 SWET1_DROME reviewed Sugar transporter SWEET1 (Protein saliva) slv CG8717 Drosophila melanogaster (Fruit fly) 226 carbohydrate transport [GO:0008643]; salivary gland development [GO:0007431] GO:0000139; GO:0005886; GO:0007431; GO:0008643; GO:0016021; GO:0051119 0 0 0 PF03083; Q7T384 CHOYP_BRAFLDRAFT_268046.3.3 m.51462 sp SC5AC_DANRE 42.511 661 333 11 14 670 4 621 8.66E-173 510 SC5AC_DANRE reviewed Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (zSMCTn) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12) (zSLC5A12) slc5a12 smctn Danio rerio (Zebrafish) (Brachydanio rerio) 623 sodium ion transport [GO:0006814] GO:0005887; GO:0006814; GO:0015129; GO:0015293; GO:0015355 0 0 0 PF00474; Q9UKA2 CHOYP_PHUM_PHUM257210.3.3 m.63466 sp FBXL4_HUMAN 27.933 179 97 5 24 170 49 227 8.66E-14 75.1 FBXL4_HUMAN reviewed F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5) FBXL4 FBL4 FBL5 Homo sapiens (Human) 621 protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0000209; GO:0004842; GO:0005654; GO:0005758; GO:0005829; GO:0006511 0 0 0 PF00646; Q9Y6R7 CHOYP_BRAFLDRAFT_66209.3.3 m.48391 sp FCGBP_HUMAN 25 360 243 9 1 353 107 446 8.66E-19 92.8 FCGBP_HUMAN reviewed IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP) FCGBP Homo sapiens (Human) 5405 0 GO:0070062 0 0 0 PF08742;PF01826;PF12714;PF00094; A2VDZ3 CHOYP_MEF2A.1.1 m.21731 sp MEF2A_BOVIN 42.45 351 125 11 1 281 1 344 8.67E-61 207 MEF2A_BOVIN reviewed Myocyte-specific enhancer factor 2A MEF2A Bos taurus (Bovine) 492 apoptotic process [GO:0006915]; cardiac conduction [GO:0061337]; cellular response to calcium ion [GO:0071277]; dendrite morphogenesis [GO:0048813]; ERK5 cascade [GO:0070375]; MAPK cascade [GO:0000165]; mitochondrial genome maintenance [GO:0000002]; mitochondrion distribution [GO:0048311]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; ventricular cardiac myofibril assembly [GO:0055005] GO:0000002; GO:0000122; GO:0000165; GO:0000790; GO:0000977; GO:0000978; GO:0000981; GO:0001077; GO:0001105; GO:0003682; GO:0003705; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0006915; GO:0033613; GO:0035035; GO:0042826; GO:0045944; GO:0046332; GO:0048311; GO:0048813; GO:0055005; GO:0061337; GO:0070375; GO:0071277 0 0 0 PF12347;PF00319; O14770 CHOYP_LOC100374249.1.1 m.58297 sp MEIS2_HUMAN 55.361 513 171 22 1 492 1 476 8.67E-146 429 MEIS2_HUMAN reviewed Homeobox protein Meis2 (Meis1-related protein 1) MEIS2 MRG1 Homo sapiens (Human) 477 eye development [GO:0001654]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pancreas development [GO:0031016]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; transcription from RNA polymerase II promoter [GO:0006366]; visual learning [GO:0008542] GO:0000122; GO:0000978; GO:0001077; GO:0001654; GO:0003700; GO:0003712; GO:0003714; GO:0005634; GO:0006366; GO:0008134; GO:0008542; GO:0009612; GO:0031016; GO:0043565; GO:0045638; GO:0045944; GO:0048471; GO:0070848 0 0 0 PF05920;PF16493; O14770 CHOYP_MEIS2.1.4 m.12275 sp MEIS2_HUMAN 55.361 513 171 22 1 492 1 476 8.67E-146 429 MEIS2_HUMAN reviewed Homeobox protein Meis2 (Meis1-related protein 1) MEIS2 MRG1 Homo sapiens (Human) 477 eye development [GO:0001654]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; pancreas development [GO:0031016]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to growth factor [GO:0070848]; response to mechanical stimulus [GO:0009612]; transcription from RNA polymerase II promoter [GO:0006366]; visual learning [GO:0008542] GO:0000122; GO:0000978; GO:0001077; GO:0001654; GO:0003700; GO:0003712; GO:0003714; GO:0005634; GO:0006366; GO:0008134; GO:0008542; GO:0009612; GO:0031016; GO:0043565; GO:0045638; GO:0045944; GO:0048471; GO:0070848 0 0 0 PF05920;PF16493; P16157 CHOYP_AASI_1435.10.35 m.32984 sp ANK1_HUMAN 36.264 546 348 0 132 677 221 766 8.67E-84 292 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P35408 CHOYP_LOC101070614.1.1 m.38644 sp PE2R4_HUMAN 25 336 202 11 21 311 20 350 8.67E-22 98.6 PE2R4_HUMAN reviewed Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor) PTGER4 PTGER2 Homo sapiens (Human) 488 "adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to glucose stimulus [GO:0071333]; cellular response to interleukin-1 [GO:0071347]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokinesis [GO:0042466]; ductus arteriosus closure [GO:0097070]; ERK1 and ERK2 cascade [GO:0070371]; female pregnancy [GO:0007565]; immune response [GO:0006955]; JNK cascade [GO:0007254]; maternal process involved in parturition [GO:0060137]; negative regulation of circadian sleep/wake cycle, REM sleep [GO:0042322]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of ductus arteriosus closure [GO:1904336]; negative regulation of endothelin secretion [GO:1904471]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; negative regulation of interleukin-1 alpha secretion [GO:0050712]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peptide secretion [GO:0002792]; negative regulation of small intestine smooth muscle contraction [GO:1904348]; negative regulation of tumor necrosis factor secretion [GO:1904468]; positive regulation of antral ovarian follicle growth [GO:2000388]; positive regulation of bone resorption [GO:0045780]; positive regulation of calcitonin secretion [GO:1904364]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokinesis [GO:1904367]; positive regulation of circadian sleep/wake cycle, non-REM sleep [GO:0046010]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 secretion [GO:2001181]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of matrix metallopeptidase secretion [GO:1904466]; positive regulation of mucus secretion [GO:0070257]; positive regulation of neutrophil extravasation [GO:2000391]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of substance P secretion, neurotransmission [GO:1904496]; positive regulation of tyrosine phosphorylation of Stat3 protein [GO:0042517]; positive regulation of urine volume [GO:0035810]; positive regulation of wound healing [GO:0090303]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of stress fiber assembly [GO:0051492]; response to amino acid [GO:0043200]; response to drug [GO:0042493]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]; response to salt [GO:1902074]; response to water-immersion restraint stress [GO:1990785]; T-helper cell differentiation [GO:0042093]" GO:0002792; GO:0004957; GO:0005886; GO:0005887; GO:0006955; GO:0007188; GO:0007189; GO:0007204; GO:0007254; GO:0007565; GO:0008284; GO:0009612; GO:0010628; GO:0010727; GO:0010840; GO:0014911; GO:0016021; GO:0030819; GO:0031965; GO:0032496; GO:0032570; GO:0032757; GO:0033624; GO:0035810; GO:0035815; GO:0042093; GO:0042322; GO:0042466; GO:0042493; GO:0042517; GO:0043025; GO:0043200; GO:0044306; GO:0045669; GO:0045780; GO:0045785; GO:0046010; GO:0050710; GO:0050712; GO:0050715; GO:0050728; GO:0050729; GO:0051492; GO:0051771; GO:0060137; GO:0060348; GO:0070257; GO:0070371; GO:0071260; GO:0071333; GO:0071347; GO:0071380; GO:0090303; GO:0097070; GO:1900127; GO:1902074; GO:1904336; GO:1904348; GO:1904364; GO:1904367; GO:1904466; GO:1904468; GO:1904471; GO:1904496; GO:1990785; GO:2000388; GO:2000391; GO:2000420; GO:2001181 0 0 0 PF00001; Q6C0Y0 CHOYP_TRIADDRAFT_57086.1.1 m.25271 sp COFI_YARLI 36.434 129 77 3 25 152 21 145 8.67E-25 96.3 COFI_YARLI reviewed Cofilin (Actin-depolymerizing factor 1) COF1 YALI0F20856g Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) 153 actin filament depolymerization [GO:0030042]; cell cycle [GO:0007049]; cell division [GO:0051301] GO:0005737; GO:0007049; GO:0015629; GO:0016363; GO:0030042; GO:0032153; GO:0051286; GO:0051301 0 0 cd11286; PF00241; Q6IR42 CHOYP_ZCWPW1.1.1 m.13268 sp ZCPW1_MOUSE 36.719 256 125 7 457 684 175 421 8.67E-40 159 ZCPW1_MOUSE reviewed Zinc finger CW-type PWWP domain protein 1 Zcwpw1 Gm1053 Mus musculus (Mouse) 630 0 GO:0008270 0 0 0 PF00855;PF07496; Q6TGV7 CHOYP_LOC100185846.1.1 m.37884 sp ABRAL_DANRE 75.309 81 20 0 44 124 1 81 8.67E-41 133 ABRAL_DANRE reviewed Costars family protein ABRACL (ABRA C-terminal-like protein) abracl si:dkey-34f16.3 Danio rerio (Zebrafish) (Brachydanio rerio) 81 0 0 0 0 0 PF14705; Q6YHK3 CHOYP_CD109.2.2 m.62801 sp CD109_HUMAN 32.016 759 460 17 724 1452 686 1418 8.67E-107 375 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q92113 CHOYP_LOC100367956.2.2 m.62044 sp CP17A_SQUAC 34.251 327 203 4 10 330 165 485 8.67E-64 213 CP17A_SQUAC reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Squalus acanthias (Spiny dogfish) 509 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q9NPB8 CHOYP_GPC1A.1.1 m.63878 sp GPCP1_HUMAN 45.779 308 161 5 1 304 305 610 8.67E-88 280 GPCP1_HUMAN reviewed Glycerophosphocholine phosphodiesterase GPCPD1 (EC 3.1.4.2) (Glycerophosphodiester phosphodiesterase 5) GPCPD1 GDE5 KIAA1434 Homo sapiens (Human) 672 cellular phosphate ion homeostasis [GO:0030643]; glycerophospholipid catabolic process [GO:0046475]; skeletal muscle tissue development [GO:0007519] GO:0005829; GO:0007519; GO:0008889; GO:0030643; GO:0046475; GO:0047389; GO:2001070 0 0 0 PF00686;PF03009; Q9Y5B6 CHOYP_PAXB1.2.2 m.63903 sp PAXB1_HUMAN 37.589 141 75 3 5 133 435 574 8.67E-22 94 PAXB1_HUMAN reviewed PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) PAXBP1 C21orf66 GCFC GCFC1 Homo sapiens (Human) 917 "muscle organ development [GO:0007517]; positive regulation of histone methylation [GO:0031062]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003700; GO:0005634; GO:0005829; GO:0006351; GO:0007517; GO:0014842; GO:0031062; GO:0045944; GO:2000288 0 0 0 PF07842; O54928 CHOYP_SOCS-5.1.1 m.11014 sp SOCS5_MOUSE 71.257 167 48 0 277 443 360 526 8.68E-83 267 SOCS5_MOUSE reviewed Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2-containing protein 5) Socs5 Cish5 Mus musculus (Mouse) 536 cell growth [GO:0016049]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; JAK-STAT cascade [GO:0007259]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of signal transduction [GO:0009968]; negative regulation of T-helper 2 cell differentiation [GO:0045629]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of T-helper 1 cell differentiation [GO:0045627]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008] GO:0004860; GO:0005154; GO:0005737; GO:0006469; GO:0007173; GO:0007175; GO:0007259; GO:0009968; GO:0016049; GO:0016567; GO:0019210; GO:0019221; GO:0030971; GO:0032436; GO:0032715; GO:0040008; GO:0042059; GO:0045627; GO:0045629; GO:0046426; GO:0050728; GO:0071638 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00017;PF12610;PF07525; Q09575 CHOYP_LOC100374860.1.1 m.14445 sp YRD6_CAEEL 30.403 273 171 8 208 477 749 1005 8.68E-30 128 YRD6_CAEEL reviewed Uncharacterized protein K02A2.6 K02A2.6 Caenorhabditis elegans 1268 DNA integration [GO:0015074] GO:0003676; GO:0008270; GO:0015074 0 0 0 PF00665;PF00078; Q502M6 CHOYP_TVAG_451090.8.13 m.61131 sp ANR29_DANRE 38.503 187 115 0 5 191 43 229 8.68E-37 132 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q52KB5 CHOYP_CG32767.1.1 m.10645 sp ZBT24_DANRE 34.568 81 51 1 271 349 379 459 8.68E-06 52.8 ZBT24_DANRE reviewed Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) zbtb24 zfp450 zgc:194556 Danio rerio (Zebrafish) (Brachydanio rerio) 672 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651;PF00096; Q62784 CHOYP_INP4A.1.1 m.7569 sp INP4A_RAT 34.896 917 510 20 166 1015 42 938 8.68E-165 511 INP4A_RAT reviewed "Type I inositol 3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I)" Inpp4a Rattus norvegicus (Rat) 939 signal transduction [GO:0007165] GO:0005737; GO:0007165; GO:0016316; GO:0034597 PATHWAY: Signal transduction; phosphatidylinositol signaling pathway. 0 0 0 Q6DJ08 CHOYP_S2538.1.2 m.13353 sp S2538_XENTR 53.901 282 128 2 7 286 20 301 8.68E-103 305 S2538_XENTR reviewed Solute carrier family 25 member 38 slc25a38 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 302 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; translation [GO:0006412] GO:0003735; GO:0005215; GO:0005743; GO:0006412; GO:0006783; GO:0016021; GO:0030218 0 0 0 PF00153; Q8K0U4 CHOYP_HS12A.7.33 m.31866 sp HS12A_MOUSE 23.138 376 220 15 11 320 150 522 8.68E-11 67 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q8WVZ9 CHOYP_BACH1.12.17 m.18647 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 8.68E-09 62.4 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q9HCS5 CHOYP_LOC100163621.1.2 m.38009 sp E41LA_HUMAN 38.674 543 228 15 1 479 90 591 8.68E-102 328 E41LA_HUMAN reviewed Band 4.1-like protein 4A (Protein NBL4) EPB41L4A EPB41L4 Homo sapiens (Human) 686 0 GO:0005737; GO:0005856; GO:0019898 0 0 0 PF08736;PF09380;PF00373;PF09379; A4FUB0 CHOYP_CE034.1.1 m.17754 sp CE034_BOVIN 27.948 458 273 12 336 772 157 578 8.69E-37 151 CE034_BOVIN reviewed Uncharacterized protein C5orf34 homolog 0 Bos taurus (Bovine) 638 0 0 0 0 0 PF15016;PF15025; B4PEU8 CHOYP_LOC101162867.2.3 m.41088 sp RS9_DROYA 83.333 138 23 0 16 153 4 141 8.69E-79 235 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; D4A1J4 CHOYP_BDH2.1.2 m.30737 sp BDH2_RAT 67.886 246 78 1 1 246 1 245 8.69E-121 347 BDH2_RAT reviewed 3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.-) (EC 1.1.1.30) (Dehydrogenase/reductase SDR family member 6) (R-beta-hydroxybutyrate dehydrogenase) Bdh2 Dhrs6 Rattus norvegicus (Rat) 245 heme metabolic process [GO:0042168]; iron ion homeostasis [GO:0055072]; siderophore biosynthetic process [GO:0019290] GO:0003858; GO:0005737; GO:0016628; GO:0019290; GO:0042168; GO:0055072 PATHWAY: Siderophore biosynthesis. 0 0 0 F7H9X2 CHOYP_LOC100888557.1.1 m.4322 sp TRIM2_CALJA 27.344 128 73 3 18 134 23 141 8.69E-13 67.4 TRIM2_CALJA reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Callithrix jacchus (White-tufted-ear marmoset) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O00214 CHOYP_LOC100535066.2.2 m.23654 sp LEG8_HUMAN 29.582 311 174 9 140 411 10 314 8.69E-28 117 LEG8_HUMAN reviewed Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) LGALS8 Homo sapiens (Human) 317 xenophagy [GO:0098792] GO:0005615; GO:0005829; GO:0016020; GO:0030246; GO:0070062; GO:0098792 0 0 0 PF00337; O77475 CHOYP_LOC100906231.1.1 m.52006 sp CPESY_DROME 29.965 287 189 5 53 337 105 381 8.69E-41 150 CPESY_DROME reviewed Ceramide phosphoethanolamine synthase (CPE synthase) (EC 2.7.8.n3) CG4585 Drosophila melanogaster (Fruit fly) 392 sphingolipid metabolic process [GO:0006665] GO:0000139; GO:0005886; GO:0006665; GO:0016021; GO:0016780 0 0 0 0 P10758 CHOYP_LOC100706287.1.1 m.44791 sp LITH_RAT 36.429 140 81 5 223 357 26 162 8.69E-21 91.3 LITH_RAT reviewed Lithostathine (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP) Reg1 Reg Rattus norvegicus (Rat) 165 calcium ion homeostasis [GO:0055074]; cellular response to chemokine [GO:1990869]; cellular response to gastrin [GO:1990878]; liver regeneration [GO:0097421]; midgut development [GO:0007494]; negative regulation of cell proliferation [GO:0008285]; pancreas regeneration [GO:1990798]; positive regulation of acinar cell proliferation [GO:1904699]; positive regulation of dendrite extension [GO:1903861]; positive regulation of gene expression [GO:0010628]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; response to acetylsalicylate [GO:1903492]; response to gastrin [GO:1990867]; response to growth hormone-releasing hormone [GO:1990864]; response to hypoxia [GO:0001666]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to water-immersion restraint stress [GO:1990785]; wound healing [GO:0042060] GO:0001666; GO:0005102; GO:0005615; GO:0005829; GO:0007494; GO:0008083; GO:0008285; GO:0010628; GO:0014070; GO:0019902; GO:0019903; GO:0030246; GO:0030426; GO:0031667; GO:0032590; GO:0032809; GO:0042060; GO:0042588; GO:0042802; GO:0042803; GO:0043234; GO:0045178; GO:0048471; GO:0051260; GO:0051289; GO:0055074; GO:0097421; GO:1903492; GO:1903861; GO:1904692; GO:1904699; GO:1990785; GO:1990798; GO:1990864; GO:1990867; GO:1990869; GO:1990878 0 0 0 PF00059; P48148 CHOYP_LOC100471656.2.2 m.34267 sp RHO1_DROME 90.104 192 19 0 1 192 1 192 8.69E-129 362 RHO1_DROME reviewed Ras-like GTP-binding protein Rho1 Rho1 CG8416 Drosophila melanogaster (Fruit fly) 192 "actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; actin-mediated cell contraction [GO:0070252]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; branch fusion, open tracheal system [GO:0035147]; cell elongation involved in imaginal disc-derived wing morphogenesis [GO:0090254]; cellularization [GO:0007349]; cellular protein localization [GO:0034613]; cellular response to DNA damage stimulus [GO:0006974]; compound eye morphogenesis [GO:0001745]; cortical actin cytoskeleton organization [GO:0030866]; cytoskeleton organization [GO:0007010]; dendrite morphogenesis [GO:0048813]; dendrite self-avoidance [GO:0070593]; determination of left/right symmetry [GO:0007368]; dorsal closure [GO:0007391]; dorsal closure, leading edge cell differentiation [GO:0046663]; dorsal closure, spreading of leading edge cells [GO:0007395]; endocytosis [GO:0006897]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of imaginal disc-derived wing hair orientation [GO:0001737]; establishment of planar polarity [GO:0001736]; establishment of planar polarity of embryonic epithelium [GO:0042249]; establishment of protein localization [GO:0045184]; establishment of tissue polarity [GO:0007164]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; gastrulation [GO:0007369]; gastrulation involving germ band extension [GO:0010004]; germ-band extension [GO:0007377]; germ cell migration [GO:0008354]; glial cell migration [GO:0008347]; hemocyte migration [GO:0035099]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived wing hair organization [GO:0035317]; JNK cascade [GO:0007254]; lumen formation, open tracheal system [GO:0035149]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; melanization defense response [GO:0035006]; mitotic actomyosin contractile ring assembly [GO:1903475]; mitotic cytokinesis [GO:0000281]; motor neuron axon guidance [GO:0008045]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuroblast proliferation [GO:0007405]; neuron projection morphogenesis [GO:0048812]; ommatidial rotation [GO:0016318]; open tracheal system development [GO:0007424]; peripheral nervous system development [GO:0007422]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of wound healing [GO:0090303]; posterior midgut invagination [GO:0007374]; protein localization involved in establishment of planar polarity [GO:0090251]; protein localization to adherens junction [GO:0071896]; pseudocleavage involved in syncytial blastoderm formation [GO:0030589]; regulation of axonogenesis [GO:0050770]; regulation of cell migration [GO:0030334]; regulation of cytoskeleton organization [GO:0051493]; regulation of embryonic cell shape [GO:0016476]; regulation of filopodium assembly [GO:0051489]; regulation of locomotor rhythm [GO:1904059]; regulation of Malpighian tubule size [GO:0035298]; regulation of myoblast fusion [GO:1901739]; regulation of tube length, open tracheal system [GO:0035159]; salivary gland morphogenesis [GO:0007435]; small GTPase mediated signal transduction [GO:0007264]; spiracle morphogenesis, open tracheal system [GO:0035277]; ventral furrow formation [GO:0007370]; visual perception [GO:0007601]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]" GO:0000281; GO:0001736; GO:0001737; GO:0001745; GO:0003924; GO:0005525; GO:0005737; GO:0005856; GO:0005886; GO:0005938; GO:0006897; GO:0006974; GO:0007010; GO:0007015; GO:0007164; GO:0007173; GO:0007254; GO:0007264; GO:0007298; GO:0007349; GO:0007368; GO:0007369; GO:0007370; GO:0007374; GO:0007377; GO:0007391; GO:0007395; GO:0007405; GO:0007411; GO:0007422; GO:0007424; GO:0007435; GO:0007480; GO:0007601; GO:0008045; GO:0008347; GO:0008354; GO:0010004; GO:0016055; GO:0016318; GO:0016476; GO:0019900; GO:0030036; GO:0030334; GO:0030589; GO:0030866; GO:0030950; GO:0031532; GO:0034613; GO:0035006; GO:0035099; GO:0035147; GO:0035149; GO:0035159; GO:0035277; GO:0035298; GO:0035317; GO:0042060; GO:0042249; GO:0044291; GO:0045179; GO:0045184; GO:0045199; GO:0046663; GO:0048812; GO:0048813; GO:0050770; GO:0051017; GO:0051489; GO:0051493; GO:0070252; GO:0070451; GO:0070593; GO:0071896; GO:0071902; GO:0090090; GO:0090251; GO:0090254; GO:0090303; GO:1901739; GO:1903475; GO:1904059 0 0 0 PF00071; P61917 CHOYP_NPC2.4.7 m.30775 sp NPC2_PANTR 43.077 130 69 2 19 143 19 148 8.69E-33 116 NPC2_PANTR reviewed Epididymal secretory protein E1 (EPI-1) (Niemann Pick type C2 protein homolog) NPC2 Pan troglodytes (Chimpanzee) 151 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; response to virus [GO:0009615] GO:0005764; GO:0005783; GO:0008203; GO:0009615; GO:0015485; GO:0030301; GO:0032367; GO:0033344; GO:0042632; GO:0070062 0 0 0 PF02221; Q2TJ95 CHOYP_BRAFLDRAFT_219342.1.2 m.53436 sp RSPO3_MOUSE 40.099 202 120 1 1 202 6 206 8.69E-55 182 RSPO3_MOUSE reviewed R-spondin-3 (Cabriolet) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Roof plate-specific spondin-3) Rspo3 Mus musculus (Mouse) 277 angiogenesis [GO:0001525]; blood vessel remodeling [GO:0001974]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055] GO:0001525; GO:0001974; GO:0002040; GO:0005102; GO:0005109; GO:0005576; GO:0008201; GO:0016055; GO:0060670; GO:0090263; GO:2000052 0 0 0 PF15913; Q70FJ1 CHOYP_TVAG_012450.2.8 m.7820 sp AKAP9_MOUSE 34.141 454 285 6 2534 2986 1678 2118 8.69E-46 188 AKAP9_MOUSE reviewed A-kinase anchor protein 9 (AKAP-9) (Protein kinase A-anchoring protein 9) (PRKA9) Akap9 Kiaa0803 Mus musculus (Mouse) 3797 microtubule nucleation [GO:0007020]; Sertoli cell development [GO:0060009]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283] GO:0000242; GO:0005737; GO:0005794; GO:0005795; GO:0005813; GO:0007020; GO:0007165; GO:0007283; GO:0036064; GO:0060009 0 0 0 PF10495; Q8WWT9 CHOYP_S13A5.1.2 m.15567 sp S13A3_HUMAN 41.227 587 309 10 18 591 15 578 8.69E-142 427 S13A3_HUMAN reviewed Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) SLC13A3 NADC3 SDCT2 Homo sapiens (Human) 602 citrate transport [GO:0015746] GO:0005886; GO:0005887; GO:0015137; GO:0015141; GO:0015183; GO:0015362; GO:0015746; GO:0017153; GO:0070062 0 0 0 PF00939; Q91YD4 CHOYP_LOC100622032.2.3 m.61271 sp TRPM2_MOUSE 26.721 494 289 13 532 985 606 1066 8.69E-38 157 TRPM2_MOUSE reviewed Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) Trpm2 Ltrpc2 Trpc7 Mus musculus (Mouse) 1507 manganese ion transport [GO:0006828]; response to hydroperoxide [GO:0033194] GO:0005262; GO:0005272; GO:0005384; GO:0005886; GO:0006828; GO:0016021; GO:0033194; GO:0047631 0 0 0 PF00520; Q0E908 CHOYP_LIMD.1.1 m.21657 sp HIL_DROME 38.947 95 56 2 336 428 11 105 8.70E-16 84.3 HIL_DROME reviewed Hillarin (D-Hillarin) (D-hil) Hil CG30147 Drosophila melanogaster (Fruit fly) 818 0 GO:0005938; GO:0008270; GO:0032154 0 0 0 PF00412; Q52L34 CHOYP_STK31.1.1 m.16299 sp MTHSD_XENLA 33.803 71 47 0 104 174 312 382 8.70E-08 54.7 MTHSD_XENLA reviewed Methenyltetrahydrofolate synthase domain-containing protein mthfsd Xenopus laevis (African clawed frog) 415 0 GO:0000166; GO:0003723 0 0 0 PF01812; Q5UPG5 CHOYP_YL086.1.1 m.33480 sp YL093_MIMIV 24.436 266 134 7 11 272 199 401 8.70E-13 72.4 YL093_MIMIV reviewed Putative ankyrin repeat protein L93 MIMI_L93 Acanthamoeba polyphaga mimivirus (APMV) 421 0 0 0 0 0 PF00023;PF12796; Q86FP7 CHOYP_RS23.1.9 m.12948 sp RS23_DERVA 87.218 133 16 1 42 173 11 143 8.70E-80 236 RS23_DERVA reviewed 40S ribosomal protein S23 RpS23 Dermacentor variabilis (American dog tick) 143 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935 0 0 cd03367; PF00164; Q96QU8 CHOYP_BRAFLDRAFT_69266.1.1 m.61432 sp XPO6_HUMAN 47.633 338 168 4 1 335 664 995 8.70E-107 340 XPO6_HUMAN reviewed Exportin-6 (Exp6) (Ran-binding protein 20) XPO6 KIAA0370 RANBP20 Homo sapiens (Human) 1125 protein export from nucleus [GO:0006611] GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006611; GO:0008565 0 0 0 PF03810;PF08389; B6Q4Z5 CHOYP_PKHM1.1.1 m.35839 sp SCONB_TALMQ 28.718 195 117 5 209 401 326 500 8.71E-14 78.2 SCONB_TALMQ reviewed Probable E3 ubiquitin ligase complex SCF subunit sconB (Sulfur controller B) (Sulfur metabolite repression control protein B) sconB PMAA_022220 Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333) (Penicillium marneffei) 660 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF00400; P97438 CHOYP_KCNK2.1.2 m.15356 sp KCNK2_MOUSE 41.848 184 96 4 1 175 161 342 8.71E-32 121 KCNK2_MOUSE reviewed Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore potassium channel TPKC1) Kcnk2 Mus musculus (Mouse) 426 cardiac ventricle development [GO:0003231]; cellular response to hypoxia [GO:0071456]; cochlea development [GO:0090102]; G-protein coupled receptor signaling pathway [GO:0007186]; memory [GO:0007613]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of DNA biosynthetic process [GO:2000279]; positive regulation of cell death [GO:0010942]; positive regulation of cellular response to hypoxia [GO:1900039]; potassium ion transport [GO:0006813]; regulation of membrane potential [GO:0042391]; response to axon injury [GO:0048678]; response to mechanical stimulus [GO:0009612]; stabilization of membrane potential [GO:0030322] GO:0003231; GO:0005249; GO:0005634; GO:0005783; GO:0005886; GO:0006813; GO:0007186; GO:0007613; GO:0008076; GO:0009612; GO:0009986; GO:0010942; GO:0015271; GO:0016324; GO:0019870; GO:0022841; GO:0030322; GO:0042391; GO:0043025; GO:0044305; GO:0048678; GO:0060044; GO:0071456; GO:0090102; GO:0097449; GO:1900039; GO:2000279 0 0 0 PF07885; Q5RBX2 CHOYP_BET1L.1.1 m.8210 sp BET1L_PONAB 51.818 110 52 1 8 117 1 109 8.71E-33 114 BET1L_PONAB reviewed BET1-like protein BET1L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 111 protein transport [GO:0015031] GO:0000139; GO:0015031; GO:0016021 0 0 0 0 Q8K339 CHOYP_BRAFLDRAFT_114345.1.1 m.14317 sp KIN17_MOUSE 59.314 408 147 5 1 407 1 390 8.71E-169 481 KIN17_MOUSE reviewed "DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein)" Kin Btcd Kin17 Mus musculus (Mouse) 391 cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mRNA processing [GO:0006397] GO:0003690; GO:0003723; GO:0005634; GO:0005737; GO:0006260; GO:0006281; GO:0006310; GO:0006397; GO:0006974; GO:0016363; GO:0043231; GO:0046872 0 0 0 PF10357; Q9CQF9 CHOYP_BRAFLDRAFT_91394.1.1 m.16068 sp PCYOX_MOUSE 39.918 486 266 13 49 515 27 505 8.71E-107 331 PCYOX_MOUSE reviewed Prenylcysteine oxidase (EC 1.8.3.5) Pcyox1 Kiaa0908 Mus musculus (Mouse) 505 prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328] GO:0001735; GO:0005764; GO:0005774; GO:0005886; GO:0008555; GO:0030327; GO:0030328; GO:0034361; GO:0070062 0 0 0 PF07156; Q9FN03 CHOYP_LOC577290.1.1 m.9546 sp UVR8_ARATH 30.363 303 190 8 14 308 86 375 8.71E-34 139 UVR8_ARATH reviewed Ultraviolet-B receptor UVR8 (Protein UV-B RESISTANCE 8) (RCC1 domain-containing protein UVR8) UVR8 At5g63860 MGI19.7 Arabidopsis thaliana (Mouse-ear cress) 440 entrainment of circadian clock [GO:0009649]; protein-chromophore linkage [GO:0018298]; response to UV [GO:0009411]; response to UV-B [GO:0010224] GO:0000785; GO:0003682; GO:0005085; GO:0005634; GO:0005829; GO:0009411; GO:0009649; GO:0009881; GO:0010224; GO:0018298; GO:0042803 0 0 0 PF00415; Q9JHA8 CHOYP_MYSP.7.9 m.42313 sp VWA7_MOUSE 27.977 529 318 15 213 729 161 638 8.71E-37 154 VWA7_MOUSE reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 D17h6s56e-3 G7c Mus musculus (Mouse) 891 0 GO:0005576 0 0 0 0 Q9JLZ3 CHOYP_AUHM.1.2 m.28846 sp AUHM_MOUSE 44.231 104 58 0 47 150 46 149 8.71E-27 105 AUHM_MOUSE reviewed "Methylglutaconyl-CoA hydratase, mitochondrial (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (muAUH)" Auh Mus musculus (Mouse) 314 "branched-chain amino acid catabolic process [GO:0009083]; fatty acid beta-oxidation [GO:0006635]; leucine catabolic process [GO:0006552]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]" GO:0000288; GO:0003723; GO:0003730; GO:0004300; GO:0004490; GO:0005739; GO:0006552; GO:0006635; GO:0009083 PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3. 0 0 PF00378; Q9UGJ0 CHOYP_AAKG2.1.1 m.55638 sp AAKG2_HUMAN 41.973 598 268 14 46 629 28 560 8.71E-142 427 AAKG2_HUMAN reviewed 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p) PRKAG2 Homo sapiens (Human) 569 ATP biosynthetic process [GO:0006754]; carnitine shuttle [GO:0006853]; cell cycle arrest [GO:0007050]; fatty acid biosynthetic process [GO:0006633]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase activity [GO:0045860]; regulation of fatty acid biosynthetic process [GO:0042304]; regulation of fatty acid metabolic process [GO:0019217]; regulation of fatty acid oxidation [GO:0046320]; regulation of glucose import [GO:0046324]; regulation of glycolytic process [GO:0006110]; regulation of signal transduction by p53 class mediator [GO:1901796]; sterol biosynthetic process [GO:0016126] GO:0004679; GO:0004862; GO:0005524; GO:0005615; GO:0005654; GO:0005829; GO:0005977; GO:0006110; GO:0006469; GO:0006633; GO:0006754; GO:0006853; GO:0007050; GO:0008603; GO:0008607; GO:0010800; GO:0016126; GO:0016208; GO:0016236; GO:0019217; GO:0019901; GO:0030295; GO:0031588; GO:0035556; GO:0042304; GO:0043531; GO:0045860; GO:0046320; GO:0046324; GO:1901796 0 0 0 PF00571; Q9UJZ1 CHOYP_LOC100169460.1.1 m.41302 sp STML2_HUMAN 62.876 299 111 0 37 335 22 320 8.71E-134 389 STML2_HUMAN reviewed "Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)" STOML2 SLP2 HSPC108 Homo sapiens (Human) 356 "CD4-positive, alpha-beta T cell activation [GO:0035710]; cellular calcium ion homeostasis [GO:0006874]; interleukin-2 production [GO:0032623]; lipid localization [GO:0010876]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; mitochondrial calcium ion transport [GO:0006851]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; positive regulation of cardiolipin metabolic process [GO:1900210]; positive regulation of mitochondrial DNA replication [GO:0090297]; positive regulation of mitochondrial membrane potential [GO:0010918]; protein oligomerization [GO:0051259]; stress-induced mitochondrial fusion [GO:1990046]; T cell receptor signaling pathway [GO:0050852]" GO:0005102; GO:0005743; GO:0005758; GO:0005856; GO:0006851; GO:0006874; GO:0007005; GO:0010876; GO:0010918; GO:0019897; GO:0032623; GO:0034982; GO:0035710; GO:0042776; GO:0045121; GO:0050852; GO:0051020; GO:0051259; GO:0090297; GO:1900210; GO:1901612; GO:1990046 0 0 0 PF01145;PF16200; C7G0B5 CHOYP_MEGF6.8.59 m.7292 sp PIF_PINFU 30.357 112 70 2 46 157 271 374 8.72E-07 55.5 PIF_PINFU reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 1007 chitin metabolic process [GO:0006030] GO:0005578; GO:0006030; GO:0008061 0 0 0 PF00092; P13010 CHOYP_LOC583472.1.1 m.25642 sp XRCC5_HUMAN 41.098 747 407 16 5 734 2 732 8.72E-178 529 XRCC5_HUMAN reviewed X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) XRCC5 G22P2 Homo sapiens (Human) 732 "cell proliferation [GO:0008283]; cellular response to gamma radiation [GO:0071480]; cellular response to X-ray [GO:0071481]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; hematopoietic stem cell differentiation [GO:0060218]; negative regulation of t-circle formation [GO:1904430]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of neurogenesis [GO:0050769]; positive regulation of type I interferon production [GO:0032481]; regulation of smooth muscle cell proliferation [GO:0048660]; telomere maintenance [GO:0000723]; transcription, DNA-templated [GO:0006351]" GO:0000723; GO:0000783; GO:0000784; GO:0003677; GO:0003684; GO:0003690; GO:0004003; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0005886; GO:0006302; GO:0006303; GO:0006310; GO:0006351; GO:0008022; GO:0008283; GO:0016020; GO:0031625; GO:0032481; GO:0042162; GO:0043564; GO:0044212; GO:0044822; GO:0044877; GO:0045892; GO:0048660; GO:0050769; GO:0060218; GO:0070419; GO:0071480; GO:0071481; GO:0075713; GO:1904430 0 0 0 PF02735;PF03730;PF03731;PF08785; P22232 CHOYP_LOC591797.1.3 m.11527 sp FBRL_XENLA 83.761 234 38 0 56 289 88 321 8.72E-148 420 FBRL_XENLA reviewed rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Histone-glutamine methyltransferase) fbl Xenopus laevis (African clawed frog) 323 histone glutamine methylation [GO:1990258]; rRNA processing [GO:0006364]; tRNA processing [GO:0008033] GO:0003723; GO:0005730; GO:0006364; GO:0008033; GO:0030529; GO:1990258; GO:1990259 0 0 0 PF01269; P48035 CHOYP_FABP4.2.2 m.54390 sp FABP4_BOVIN 36.364 88 53 2 8 92 3 90 8.72E-11 58.2 FABP4_BOVIN reviewed "Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)" FABP4 Bos taurus (Bovine) 132 "brown fat cell differentiation [GO:0050873]; cellular response to lithium ion [GO:0071285]; cholesterol homeostasis [GO:0042632]; cytokine production [GO:0001816]; fatty acid metabolic process [GO:0006631]; negative regulation of gene expression [GO:0010629]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; white fat cell differentiation [GO:0050872]" GO:0001816; GO:0005215; GO:0005504; GO:0005634; GO:0005829; GO:0006469; GO:0006631; GO:0008284; GO:0010628; GO:0010629; GO:0042632; GO:0045892; GO:0050729; GO:0050872; GO:0050873; GO:0071285 0 0 0 PF00061; Q13114 CHOYP_BRAFLDRAFT_237984.1.1 m.26104 sp TRAF3_HUMAN 41.864 590 275 17 11 565 9 565 8.72E-143 427 TRAF3_HUMAN reviewed TNF receptor-associated factor 3 (EC 6.3.2.-) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) TRAF3 CAP1 CRAF1 Homo sapiens (Human) 568 apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of type I interferon production [GO:0032480]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; toll-like receptor signaling pathway [GO:0002224]; Toll signaling pathway [GO:0008063]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0001817; GO:0002224; GO:0004842; GO:0004871; GO:0005164; GO:0005739; GO:0005768; GO:0005829; GO:0006915; GO:0007165; GO:0008063; GO:0008270; GO:0009898; GO:0016874; GO:0019903; GO:0030162; GO:0031625; GO:0031996; GO:0032088; GO:0032480; GO:0032648; GO:0033209; GO:0035631; GO:0035666; GO:0042981; GO:0045087; GO:0050688 0 0 0 PF02176; Q5ZHN9 CHOYP_PGPS1.1.1 m.10148 sp PGPS1_CHICK 45.344 494 238 7 60 524 66 556 8.72E-142 422 PGPS1_CHICK reviewed "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 1) (PGP synthase 1)" PGS1 RCJMB04_35a14 Gallus gallus (Chicken) 557 phosphatidylglycerol biosynthetic process [GO:0006655] GO:0005524; GO:0005739; GO:0005783; GO:0006655; GO:0008444 PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2. 0 0 0 Q6P8D9 CHOYP_UBC12.1.1 m.51806 sp UBC12_XENTR 85.792 183 25 1 25 206 1 183 8.72E-115 327 UBC12_XENTR reviewed NEDD8-conjugating enzyme Ubc12 (EC 6.3.2.-) (NEDD8 carrier protein) (NEDD8 protein ligase) (Ubiquitin-conjugating enzyme E2 M) ube2m ubc12 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 183 cellular protein modification process [GO:0006464]; protein neddylation [GO:0045116] GO:0004842; GO:0005524; GO:0005737; GO:0006464; GO:0018169; GO:0019788; GO:0045116 PATHWAY: Protein modification; protein neddylation. 0 0 PF00179; Q6ZU80 CHOYP_LOC100378618.1.1 m.48704 sp CE128_HUMAN 29.191 1038 663 18 1 986 37 1054 8.72E-107 361 CE128_HUMAN reviewed Centrosomal protein of 128 kDa (Cep128) CEP128 C14orf145 C14orf61 Homo sapiens (Human) 1094 0 GO:0000922; GO:0005737; GO:0005814; GO:0005815 0 0 0 0 Q80U87 CHOYP_TTHERM_00445960.1.1 m.63977 sp UBP8_MOUSE 25.501 349 173 12 140 447 740 1042 8.72E-17 87.4 UBP8_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (mUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) Usp8 Kiaa0055 Ubpy Mus musculus (Mouse) 1080 endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000281; GO:0004843; GO:0005622; GO:0005654; GO:0005737; GO:0005769; GO:0005794; GO:0005829; GO:0006511; GO:0007032; GO:0007265; GO:0016579; GO:0019897; GO:0030496; GO:0031313; GO:0070536; GO:0071108 0 0 0 PF00581;PF00443;PF08969; Q86U86 CHOYP_PB1.6.6 m.48864 sp PB1_HUMAN 41.584 101 40 3 30 128 1378 1461 8.72E-14 74.7 PB1_HUMAN reviewed Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) PBRM1 BAF180 PB1 Homo sapiens (Human) 1689 "chromatin remodeling [GO:0006338]; covalent chromatin modification [GO:0016569]; mitotic nuclear division [GO:0007067]; negative regulation of cell proliferation [GO:0008285]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000228; GO:0003677; GO:0003682; GO:0005654; GO:0006338; GO:0006351; GO:0006355; GO:0007067; GO:0008285; GO:0016569; GO:0090544 0 0 0 PF01426;PF00439;PF00505; Q8VCZ6 CHOYP_SGSM3.2.3 m.39182 sp SGSM3_MOUSE 76.667 150 35 0 1 150 599 748 8.72E-78 248 SGSM3_MOUSE reviewed Small G protein signaling modulator 3 (RUN and TBC1 domain-containing protein 3) Sgsm3 Cip85 Rutbc3 Mus musculus (Mouse) 750 activation of GTPase activity [GO:0090630]; cell cycle arrest [GO:0007050]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227]; positive regulation of protein catabolic process [GO:0045732]; Rap protein signal transduction [GO:0032486]; regulation of Rab protein signal transduction [GO:0032483]; regulation of vesicle fusion [GO:0031338] GO:0005096; GO:0005622; GO:0005829; GO:0005921; GO:0006886; GO:0007050; GO:0012505; GO:0017137; GO:0030695; GO:0031338; GO:0032483; GO:0032486; GO:0045732; GO:0048227; GO:0090630 0 0 0 PF00566;PF02759;PF00018; Q98943 CHOYP_LOC100892193.1.5 m.13369 sp CASP2_CHICK 28.153 444 258 11 1 413 7 420 8.72E-40 150 CASP2_CHICK reviewed Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] CASP2 ICH1 Gallus gallus (Chicken) 424 regulation of apoptotic process [GO:0042981] GO:0005737; GO:0042981; GO:0097153 0 0 0 PF00619; Q9VAC5 CHOYP_ADA17.1.3 m.796 sp ADA17_DROME 37.926 646 354 20 5 627 14 635 8.72E-126 396 ADA17_DROME reviewed ADAM 17-like protease (EC 3.4.24.-) Tace CG7908 Drosophila melanogaster (Fruit fly) 732 membrane protein ectodomain proteolysis [GO:0006509] GO:0004222; GO:0006509; GO:0008270; GO:0016021 0 0 0 PF16698;PF00200;PF01562; Q9Y5Q5 CHOYP_AAEL_AAEL010655.1.1 m.9253 sp CORIN_HUMAN 29.661 590 351 18 375 922 463 1030 8.72E-69 251 CORIN_HUMAN reviewed "Atrial natriuretic peptide-converting enzyme (EC 3.4.21.-) (Corin) (Heart-specific serine proteinase ATC2) (Pro-ANP-converting enzyme) (Transmembrane protease serine 10) [Cleaved into: Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]" CORIN CRN TMPRSS10 Homo sapiens (Human) 1042 female pregnancy [GO:0007565]; peptide hormone processing [GO:0016486]; regulation of blood pressure [GO:0008217]; regulation of cardiac conduction [GO:1903779]; regulation of renal sodium excretion [GO:0035813]; regulation of systemic arterial blood pressure by atrial natriuretic peptide [GO:0003050] GO:0003050; GO:0004252; GO:0005576; GO:0005886; GO:0005887; GO:0007565; GO:0008217; GO:0009986; GO:0016021; GO:0016486; GO:0035813; GO:1903779 0 0 cd00190; PF01392;PF00057;PF15494;PF00089; G5ED84 CHOYP_LOC100575377.2.10 m.14724 sp KLHL8_CAEEL 26.875 160 105 4 10 158 88 246 8.73E-09 62.4 KLHL8_CAEEL reviewed Kelch-like protein 8 kel-8 W02G9.2 Caenorhabditis elegans 690 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0014069; GO:0016567; GO:0030054; GO:0031463; GO:0042787; GO:0043005; GO:0043025 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; O75197 CHOYP_LOC100378652.1.1 m.5657 sp LRP5_HUMAN 35.316 269 162 5 57 323 330 588 8.73E-45 171 LRP5_HUMAN reviewed Low-density lipoprotein receptor-related protein 5 (LRP-5) LRP5 LR3 LRP7 Homo sapiens (Human) 1615 "adipose tissue development [GO:0060612]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in patterning of blood vessels [GO:1902262]; beta-catenin destruction complex disassembly [GO:1904886]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling involved in mammary gland development [GO:0060764]; cell migration involved in gastrulation [GO:0042074]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; glucose catabolic process [GO:0006007]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; osteoblast development [GO:0002076]; positive regulation of cell proliferation [GO:0008284]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of bone remodeling [GO:0046850]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; retinal blood vessel morphogenesis [GO:0061304]; retina morphogenesis in camera-type eye [GO:0060042]; somatic stem cell population maintenance [GO:0035019]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]" GO:0001702; GO:0002053; GO:0002076; GO:0005739; GO:0005783; GO:0005886; GO:0006007; GO:0006897; GO:0008203; GO:0008217; GO:0008284; GO:0009952; GO:0016021; GO:0016055; GO:0017147; GO:0033690; GO:0035019; GO:0035426; GO:0042074; GO:0042632; GO:0042733; GO:0042813; GO:0042981; GO:0043235; GO:0044332; GO:0045600; GO:0045668; GO:0045840; GO:0045893; GO:0045944; GO:0046849; GO:0046850; GO:0048539; GO:0051091; GO:0060033; GO:0060042; GO:0060070; GO:0060349; GO:0060444; GO:0060612; GO:0060764; GO:0060828; GO:0061178; GO:0061304; GO:0071901; GO:0071936; GO:1902262; GO:1904886; GO:1904928; GO:1990851; GO:1990909 0 0 0 PF00057;PF00058; P10039 CHOYP_DWIL_GK22020.1.1 m.12523 sp TENA_CHICK 41.667 132 73 3 2 133 1668 1795 8.73E-30 115 TENA_CHICK reviewed Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) TNC Gallus gallus (Chicken) 1808 cell adhesion [GO:0007155]; regulation of cell proliferation [GO:0042127] GO:0005578; GO:0007155; GO:0042127 0 0 0 PF07974;PF00147;PF00041;PF12661; P16157 CHOYP_LOC100197555.4.7 m.54478 sp ANK1_HUMAN 45.37 108 59 0 3 110 321 428 8.73E-20 86.7 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P20693 CHOYP_contig_002231 m.2413 sp FCER2_MOUSE 35.938 128 66 5 45 170 193 306 8.73E-17 81.6 FCER2_MOUSE reviewed Low affinity immunoglobulin epsilon Fc receptor (Fc-epsilon-RII) (Lymphocyte IgE receptor) (CD antigen CD23) Fcer2 Fcer2a Mus musculus (Mouse) 331 positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0009897; GO:0016021; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; P91931 CHOYP_LOC100742284.1.1 m.58105 sp DCAM_DROME 49.401 334 150 5 21 337 8 339 8.73E-107 318 DCAM_DROME reviewed S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain] SamDC CG5029 Drosophila melanogaster (Fruit fly) 347 defense response to Gram-negative bacterium [GO:0050829]; S-adenosylmethioninamine biosynthetic process [GO:0006557]; spermidine biosynthetic process [GO:0008295]; spermine biosynthetic process [GO:0006597] GO:0004014; GO:0005829; GO:0006557; GO:0006597; GO:0008295; GO:0050829 PATHWAY: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. 0 0 PF01536; I6V1W0 CHOYP_BMBL.1.1 m.16634 sp BMBL_DANRE 29.066 578 369 8 34 582 38 603 8.74E-72 244 BMBL_DANRE reviewed Protein brambleberry bmb Danio rerio (Zebrafish) (Brachydanio rerio) 612 karyomere membrane fusion [GO:0061472]; pronuclear fusion [GO:0007344] GO:0007344; GO:0016021; GO:0031965; GO:0061472 0 0 0 0 Q0X0C4 CHOYP_HEXIM1.1.1 m.49487 sp HEXI1_BOVIN 38.428 229 110 5 96 313 92 300 8.74E-37 137 HEXI1_BOVIN reviewed Protein HEXIM1 HEXIM1 Bos taurus (Bovine) 320 "heart development [GO:0007507]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0004861; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0007507; GO:0045736; GO:0097322; GO:1901798 0 0 0 PF15313; Q23445 CHOYP_LOC100371319.1.1 m.10776 sp SAR1_CAEEL 72.251 191 53 0 2 192 3 193 8.74E-105 302 SAR1_CAEEL reviewed GTP-binding protein SAR1 ZK180.4 Caenorhabditis elegans 193 embryo development ending in birth or egg hatching [GO:0009792]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005525; GO:0005783; GO:0005794; GO:0006886; GO:0009792; GO:0016192 0 0 0 PF00025; Q642H9 CHOYP_CTL2.1.2 m.3858 sp RS4X_DANRE 76.132 243 58 0 64 306 19 261 8.74E-143 405 RS4X_DANRE reviewed "40S ribosomal protein S4, X isoform" rps4x rps4 zgc:92076 Danio rerio (Zebrafish) (Brachydanio rerio) 263 brain development [GO:0007420]; chordate embryonic development [GO:0043009]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0007420; GO:0019843; GO:0022627; GO:0043009 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q66I24 CHOYP_ASSY.3.4 m.61045 sp ASSY_DANRE 66.929 127 42 0 23 149 229 355 8.74E-60 193 ASSY_DANRE reviewed Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) ass1 ass zgc:92051 Danio rerio (Zebrafish) (Brachydanio rerio) 414 arginine biosynthetic process [GO:0006526]; argininosuccinate metabolic process [GO:0000053]; urea cycle [GO:0000050] GO:0000050; GO:0000053; GO:0004055; GO:0005524; GO:0005737; GO:0006526 PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.; PATHWAY: Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. 0 cd01999; PF00764; Q8N5I4 CHOYP_DHRSX.1.2 m.4588 sp DHRSX_HUMAN 37.107 318 192 3 15 328 9 322 8.74E-67 216 DHRSX_HUMAN reviewed Dehydrogenase/reductase SDR family member on chromosome X (EC 1.1.-.-) (DHRSXY) (Short chain dehydrogenase/reductase family 46C member 1) (Short chain dehydrogenase/reductase family 7C member 6) DHRSX CXorf11 DHRS5X SDR46C1 SDR7C6 UNQ6508/PRO21433 Homo sapiens (Human) 330 0 GO:0016491 0 0 0 PF00106; Q8N8U2 CHOYP_LOC100370742.1.1 m.52447 sp CDYL2_HUMAN 47.17 265 137 1 571 832 237 501 8.74E-77 261 CDYL2_HUMAN reviewed Chromodomain Y-like protein 2 (CDY-like 2) CDYL2 Homo sapiens (Human) 506 metabolic process [GO:0008152] GO:0003824; GO:0005634; GO:0008152 0 0 0 PF00385;PF00378; O01761 CHOYP_LOAG_01021.1.4 m.1826 sp UNC89_CAEEL 25.709 564 362 18 1239 1760 5233 5781 8.75E-32 141 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O61231 CHOYP_RL10.1.3 m.11695 sp RL10_DROME 82.243 214 38 0 1 214 1 214 8.75E-132 372 RL10_DROME reviewed 60S ribosomal protein L10 (QM protein homolog) (dQM) RpL10 Qm CG17521 Drosophila melanogaster (Fruit fly) 218 centrosome duplication [GO:0051298]; centrosome organization [GO:0051297]; mitotic spindle elongation [GO:0000022]; mitotic spindle organization [GO:0007052]; ribosomal large subunit assembly [GO:0000027]; sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0000022; GO:0000027; GO:0003735; GO:0005737; GO:0005840; GO:0006412; GO:0007052; GO:0019233; GO:0022625; GO:0043025; GO:0051297; GO:0051298 0 0 cd01433; PF00252; P28570 CHOYP_S6A11.1.1 m.58009 sp SC6A8_RAT 42.259 239 97 6 22 245 3 215 8.75E-54 189 SC6A8_RAT reviewed Sodium- and chloride-dependent creatine transporter 1 (CHOT1) (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8) Slc6a8 Rattus norvegicus (Rat) 635 creatine transport [GO:0015881]; embryonic brain development [GO:1990403] GO:0005308; GO:0005309; GO:0005328; GO:0005886; GO:0005887; GO:0015220; GO:0015881; GO:1990403 0 0 0 PF00209; Q5DU00 CHOYP_LOC100376412.3.3 m.60772 sp DCDC2_MOUSE 28.062 449 249 16 20 449 19 412 8.75E-34 139 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q6IMH0 CHOYP_LOC100179516.2.2 m.49937 sp TEPP_MOUSE 40.741 189 93 4 30 203 31 215 8.75E-37 130 TEPP_MOUSE reviewed "Testis, prostate and placenta-expressed protein" Tepp Mus musculus (Mouse) 216 0 0 0 0 0 0 Q8NFW1 CHOYP_VWCE.1.3 m.5011 sp COMA1_HUMAN 37.778 90 52 3 28 116 139 225 8.75E-11 61.2 COMA1_HUMAN reviewed Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) 1626 0 GO:0005576; GO:0005578; GO:0005581; GO:0005788 0 0 0 PF01391;PF00092; Q9ESN6 CHOYP_contig_054024 m.64600 sp TRIM2_MOUSE 27.933 179 112 7 75 246 535 703 8.75E-10 62 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H3K2 CHOYP_LOC100693508.1.1 m.16381 sp GHITM_HUMAN 60.064 313 115 4 31 333 33 345 8.75E-118 346 GHITM_HUMAN reviewed Growth hormone-inducible transmembrane protein (Dermal papilla-derived protein 2) (Mitochondrial morphology and cristae structure 1) (MICS1) (Transmembrane BAX inhibitor motif-containing protein 5) GHITM DERP2 MICS1 TMBIM5 My021 UNQ244/PRO281 Homo sapiens (Human) 345 apoptotic process [GO:0006915] GO:0005743; GO:0006915; GO:0016021; GO:0070062 0 0 0 0 Q9TV98 CHOYP_ER.2.2 m.28743 sp ESR1_HORSE 44.173 369 175 7 192 534 182 545 8.75E-93 298 ESR1_HORSE reviewed Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) ESR1 ESR NR3A1 Equus caballus (Horse) 594 "cellular response to estradiol stimulus [GO:0071392]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005496; GO:0005634; GO:0005794; GO:0005886; GO:0006351; GO:0007200; GO:0007204; GO:0008270; GO:0010863; GO:0030284; GO:0030518; GO:0043124; GO:0043433; GO:0043565; GO:0045429; GO:0045893; GO:0051000; GO:0051091; GO:0071392 0 0 0 PF12743;PF00104;PF02159;PF00105; O13262 CHOYP_LOC100891438.3.3 m.32194 sp SCNNC_XENLA 22.095 525 317 18 90 528 57 575 8.76E-17 88.2 SCNNC_XENLA reviewed Amiloride-sensitive sodium channel subunit beta-2 (Beta-2-NaCH) (Epithelial Na(+) channel subunit beta-2) (Beta-2-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta-2) (SCNEB2) scnn1b-b Xenopus laevis (African clawed frog) 646 sodium ion transmembrane transport [GO:0035725] GO:0015280; GO:0016021; GO:0016324; GO:0030659; GO:0035725 0 0 0 PF00858; O70277 CHOYP_BRAFLDRAFT_206799.2.23 m.3254 sp TRIM3_RAT 28 150 103 3 55 200 595 743 8.76E-11 64.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P22031 CHOYP_BRAFLDRAFT_95854.6.6 m.61752 sp LEG_HELCR 37.778 90 53 1 37 123 13 102 8.76E-12 63.5 LEG_HELCR reviewed D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 105 0 GO:0005737; GO:0030246 0 0 0 PF02140; P46825 CHOYP_KLC2.1.1 m.37987 sp KLC_DORPE 86.29 124 17 0 2 125 380 503 8.76E-72 227 KLC_DORPE reviewed Kinesin light chain (KLC) 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 571 0 GO:0003777; GO:0005737; GO:0005871; GO:0005874 0 0 0 PF13374; P62890 CHOYP_LOC659206.4.6 m.29648 sp RL30_RAT 81.416 113 21 0 54 166 1 113 8.76E-65 197 RL30_RAT reviewed 60S ribosomal protein L30 Rpl30 Rattus norvegicus (Rat) 115 liver regeneration [GO:0097421]; positive regulation of selenocysteine incorporation [GO:1904571]; selenocysteine metabolic process [GO:0016259]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0005829; GO:0005840; GO:0005925; GO:0006412; GO:0016020; GO:0016259; GO:0022625; GO:0035368; GO:0070062; GO:0097421; GO:1904571 0 0 0 PF01248; Q13485 CHOYP_SMAD4.4.4 m.25513 sp SMAD4_HUMAN 58.957 441 138 9 1 406 6 438 8.76E-156 454 SMAD4_HUMAN reviewed Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) SMAD4 DPC4 MADH4 Homo sapiens (Human) 552 "atrioventricular canal development [GO:0036302]; atrioventricular valve formation [GO:0003190]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell proliferation [GO:0008283]; cellular iron ion homeostasis [GO:0006879]; cellular response to BMP stimulus [GO:0071773]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; endocardial cell differentiation [GO:0060956]; endoderm development [GO:0007492]; endothelial cell activation [GO:0042118]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; female gonad morphogenesis [GO:0061040]; formation of anatomical boundary [GO:0048859]; gastrulation with mouth forming second [GO:0001702]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; mesoderm development [GO:0007498]; metanephric mesenchyme morphogenesis [GO:0072133]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell death [GO:0060548]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural crest cell differentiation [GO:0014033]; neuron fate commitment [GO:0048663]; ovarian follicle development [GO:0001541]; palate development [GO:0060021]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cell proliferation involved in heart valve morphogenesis [GO:0003251]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of SMAD protein import into nucleus [GO:0060391]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of binding [GO:0051098]; regulation of hair follicle development [GO:0051797]; regulation of transforming growth factor beta2 production [GO:0032909]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to transforming growth factor beta [GO:0071559]; sebaceous gland development [GO:0048733]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; SMAD protein complex assembly [GO:0007183]; SMAD protein signal transduction [GO:0060395]; somatic stem cell population maintenance [GO:0035019]; somite rostral/caudal axis specification [GO:0032525]; spermatogenesis [GO:0007283]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]" GO:0000122; GO:0000790; GO:0000978; GO:0000987; GO:0001076; GO:0001077; GO:0001541; GO:0001658; GO:0001666; GO:0001701; GO:0001702; GO:0003190; GO:0003198; GO:0003220; GO:0003251; GO:0003360; GO:0003682; GO:0005634; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0006879; GO:0007179; GO:0007183; GO:0007283; GO:0007338; GO:0007411; GO:0007492; GO:0007498; GO:0008283; GO:0008285; GO:0010614; GO:0010718; GO:0010862; GO:0014033; GO:0017015; GO:0030308; GO:0030509; GO:0030511; GO:0030513; GO:0030616; GO:0032444; GO:0032525; GO:0032909; GO:0033686; GO:0035019; GO:0035556; GO:0036302; GO:0042118; GO:0042733; GO:0042802; GO:0042803; GO:0044212; GO:0045892; GO:0045893; GO:0045944; GO:0046872; GO:0046881; GO:0048589; GO:0048663; GO:0048733; GO:0048859; GO:0051098; GO:0051571; GO:0051797; GO:0060021; GO:0060065; GO:0060391; GO:0060395; GO:0060412; GO:0060548; GO:0060956; GO:0061040; GO:0070102; GO:0070373; GO:0070411; GO:0070412; GO:0071141; GO:0071559; GO:0071773; GO:0072133; GO:0072134; GO:0072520; GO:1901522; GO:2000617 0 0 0 PF03165;PF03166; Q6TFL4 CHOYP_KLHL24.4.4 m.59670 sp KLH24_HUMAN 29.963 544 364 7 21 559 59 590 8.76E-72 244 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q6TH22 CHOYP_LOC658280.1.1 m.18469 sp DDI2_DANRE 59.296 398 135 4 9 385 13 404 8.76E-158 455 DDI2_DANRE reviewed Protein DDI1 homolog 2 ddi2 Danio rerio (Zebrafish) (Brachydanio rerio) 411 0 GO:0004190 0 0 0 PF09668;PF00240; Q7LHG5 CHOYP_LOC579970.5.5 m.25257 sp YI31B_YEAST 30.565 903 554 22 2 891 636 1478 8.76E-116 389 YI31B_YEAST reviewed Transposon Ty3-I Gag-Pol polyprotein (Gag3-Pol3) (Transposon Ty3-2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA) (p24); Spacer peptide p3; Nucleocapsid protein p11 (NC); Ty3 protease (PR) (EC 3.4.23.-) (p16); Spacer peptide J; Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p55); Integrase p52 (IN); Integrase p49 (IN)] TY3B-I YILWTy3-1 POL YIL082W-A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 1498 "DNA integration [GO:0015074]; DNA recombination [GO:0006310]; transposition, RNA-mediated [GO:0032197]; viral release from host cell [GO:0019076]" GO:0000943; GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004523; GO:0004540; GO:0005524; GO:0005634; GO:0005737; GO:0006310; GO:0008233; GO:0008270; GO:0015074; GO:0019076; GO:0032197 0 0 0 PF12384;PF00665;PF00078; Q86SS6 CHOYP_LOC100883326.1.2 m.51657 sp SYT9_HUMAN 54.78 387 164 4 25 407 110 489 8.76E-142 417 SYT9_HUMAN reviewed Synaptotagmin-9 (Synaptotagmin IX) (SytIX) SYT9 Homo sapiens (Human) 491 calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; regulation of calcium ion-dependent exocytosis [GO:0017158]; regulation of insulin secretion [GO:0050796]; vesicle fusion [GO:0006906] GO:0005509; GO:0005544; GO:0005886; GO:0006906; GO:0016021; GO:0017158; GO:0019905; GO:0030054; GO:0030276; GO:0030667; GO:0030672; GO:0031045; GO:0045956; GO:0048791; GO:0050796; GO:0070382 0 0 0 PF00168; Q8IXR9 CHOYP_LOC100893889.2.2 m.64934 sp CL056_HUMAN 31.045 670 378 18 11 656 12 621 8.76E-90 295 CL056_HUMAN reviewed Uncharacterized protein C12orf56 C12orf56 Homo sapiens (Human) 622 0 0 0 0 0 PF15087; Q96KN3 CHOYP_PKNX1.1.1 m.14403 sp PKNX2_HUMAN 54.762 336 116 4 46 364 65 381 8.76E-107 327 PKNX2_HUMAN reviewed Homeobox protein PKNOX2 (Homeobox protein PREP-2) (PBX/knotted homeobox 2) PKNOX2 PREP2 Homo sapiens (Human) 472 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000977; GO:0005634; GO:0005737; GO:0006357; GO:0015629; GO:0015630 0 0 0 PF05920;PF16493; Q9I8C7 CHOYP_NACHRA5.2.2 m.56391 sp ACH10_CHICK 37.079 445 243 8 4 440 34 449 8.76E-101 311 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; Q9NRH1 CHOYP_YAED1.1.1 m.62625 sp YAED1_HUMAN 29.703 101 60 3 39 136 18 110 8.76E-07 50.4 YAED1_HUMAN reviewed Yae1 domain-containing protein 1 YAE1D1 C7orf36 GK003 Homo sapiens (Human) 226 0 0 0 0 0 PF09811; O14522 CHOYP_PTPRA.12.22 m.50923 sp PTPRT_HUMAN 31.677 644 406 12 22 635 800 1439 8.77E-92 313 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O95983 CHOYP_ISCW_ISCW010143.2.3 m.37551 sp MBD3_HUMAN 51.429 105 45 2 4 105 94 195 8.77E-29 108 MBD3_HUMAN reviewed Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3) MBD3 Homo sapiens (Human) 291 "aging [GO:0007568]; ATP-dependent chromatin remodeling [GO:0043044]; brain development [GO:0007420]; embryonic organ development [GO:0048568]; heart development [GO:0007507]; histone acetylation [GO:0016573]; in utero embryonic development [GO:0001701]; methylation-dependent chromatin silencing [GO:0006346]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of DNA methylation [GO:0044030]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to estradiol [GO:0032355]; response to nutrient levels [GO:0031667]; tissue development [GO:0009888]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000790; GO:0000792; GO:0001701; GO:0003677; GO:0003682; GO:0004407; GO:0005654; GO:0005737; GO:0006346; GO:0006351; GO:0007420; GO:0007507; GO:0007568; GO:0008327; GO:0009888; GO:0016573; GO:0016581; GO:0031667; GO:0032355; GO:0043044; GO:0043234; GO:0044030; GO:0048568; GO:1901796 0 0 0 PF01429;PF14048;PF16564; P54813 CHOYP_LOC582354.1.1 m.18045 sp YME1_CAEEL 46.171 457 234 5 161 608 238 691 8.77E-136 416 YME1_CAEEL reviewed ATP-dependent zinc metalloprotease YME1 homolog (EC 3.4.24.-) ymel-1 M03C11.5 Caenorhabditis elegans 723 misfolded or incompletely synthesized protein catabolic process [GO:0006515]; mitochondrion organization [GO:0007005] GO:0004176; GO:0004222; GO:0005524; GO:0005743; GO:0006515; GO:0007005; GO:0008237; GO:0016021; GO:0046872 0 0 0 PF00004;PF01434; P84875 CHOYP_LOC100724365.1.1 m.27274 sp PCPI_SABMA 48.077 104 54 0 61 164 3 106 8.77E-32 123 PCPI_SABMA reviewed Carboxypeptidase inhibitor SmCI 0 Sabellastarte magnifica (Feather duster) 165 0 GO:0004867; GO:0008191 0 0 0 PF00014; Q16981 CHOYP_APLC.2.2 m.9653 sp NCS1_APLCA 81.579 190 35 0 1 190 1 190 8.77E-114 325 NCS1_APLCA reviewed Neuronal calcium sensor 1 (NCS-1) (Aplycalcin) 0 Aplysia californica (California sea hare) 191 0 GO:0005509 0 0 0 PF00036;PF13499; Q3V384 CHOYP_LOC100642494.1.1 m.58088 sp LACE1_MOUSE 50.824 425 198 6 86 510 59 472 8.77E-145 427 LACE1_MOUSE reviewed Lactation elevated protein 1 Lace1 Mus musculus (Mouse) 480 0 GO:0005524; GO:0005739 0 0 0 PF03969; Q6DID3 CHOYP_PHUM_PHUM600390.1.1 m.6641 sp SCAF8_MOUSE 59.901 202 73 1 1 202 1 194 8.77E-63 238 SCAF8_MOUSE reviewed Protein SCAF8 (RNA-binding motif protein 16) (SR-related and CTD-associated factor 8) Scaf8 Kiaa1116 Rbm16 Mus musculus (Mouse) 1268 mRNA processing [GO:0006397]; RNA splicing [GO:0008380] GO:0000166; GO:0003723; GO:0005654; GO:0005681; GO:0006397; GO:0008380; GO:0016363; GO:0043175 0 0 0 PF04818;PF00076; Q8WVZ9 CHOYP_BACH1.10.17 m.18532 sp KBTB7_HUMAN 31.405 121 72 3 12 122 45 164 8.77E-09 62 KBTB7_HUMAN reviewed Kelch repeat and BTB domain-containing protein 7 KBTBD7 Homo sapiens (Human) 684 MAPK cascade [GO:0000165]; protein ubiquitination [GO:0016567] GO:0000165; GO:0005829; GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q96MM6 CHOYP_HS12B.10.14 m.59859 sp HS12B_HUMAN 30.168 653 380 19 838 1420 37 683 8.77E-75 267 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9BQT8 CHOYP_LOC100376719.1.1 m.66046 sp ODC_HUMAN 66.549 284 94 1 22 305 16 298 8.77E-142 404 ODC_HUMAN reviewed Mitochondrial 2-oxodicarboxylate carrier (Solute carrier family 25 member 21) SLC25A21 ODC Homo sapiens (Human) 299 lysine catabolic process [GO:0006554]; translation [GO:0006412] GO:0003735; GO:0005743; GO:0006412; GO:0006554; GO:0015139; GO:0016021 0 0 0 PF00153; Q9R1R2 CHOYP_contig_050232 m.59732 sp TRIM3_MOUSE 26.141 241 142 6 6 243 12 219 8.77E-19 93.6 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_255103.4.18 m.27368 sp TRIM2_AILME 25 156 116 1 129 284 589 743 8.78E-07 55.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_85511.22.23 m.64737 sp TRIM2_AILME 22.353 255 155 9 144 383 468 694 8.78E-09 60.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15062 CHOYP_LOC100369002.1.1 m.39125 sp ZBTB5_HUMAN 31.959 97 63 2 29 122 22 118 8.78E-06 52.8 ZBTB5_HUMAN reviewed Zinc finger and BTB domain-containing protein 5 ZBTB5 KIAA0354 Homo sapiens (Human) 677 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00651; O75382 CHOYP_BRAFLDRAFT_79421.2.3 m.32991 sp TRIM3_HUMAN 23.464 358 206 16 219 537 401 729 8.78E-11 68.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P68372 CHOYP_TBB4B.5.7 m.41162 sp TBB4B_MOUSE 98.712 233 3 0 1 233 73 305 8.78E-171 481 TBB4B_MOUSE reviewed Tubulin beta-4B chain (Tubulin beta-2C chain) Tubb4b Tubb2c Mus musculus (Mouse) 445 microtubule-based process [GO:0007017] GO:0003725; GO:0003924; GO:0005200; GO:0005525; GO:0005634; GO:0005737; GO:0005874; GO:0007017; GO:0043209; GO:0045298; GO:0070062; GO:1903561 0 0 0 PF00091;PF03953; Q0VA40 CHOYP_SP9.1.1 m.35770 sp SP9_XENTR 51.095 411 150 15 7 391 7 392 8.78E-109 330 SP9_XENTR reviewed Transcription factor Sp9 sp9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 422 "embryonic limb morphogenesis [GO:0030326]; embryonic pectoral fin morphogenesis [GO:0035118]; positive regulation of fibroblast growth factor receptor signaling pathway [GO:0045743]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0030326; GO:0035118; GO:0045743; GO:0046872 0 0 0 PF00096; Q24799 CHOYP_MYPH.2.2 m.61259 sp MYPH_ECHGR 60.87 161 62 1 1 160 18 178 8.78E-67 204 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q4V7A9 CHOYP_LOC753836.1.1 m.62155 sp K895L_RAT 30.814 344 209 9 30 367 138 458 8.78E-42 161 K895L_RAT reviewed Uncharacterized protein KIAA0895-like Kiaa0895l Rattus norvegicus (Rat) 468 0 0 0 0 0 PF08014; Q58CU3 CHOYP_HBAP1.1.1 m.13890 sp HBAP1_BOVIN 56.186 194 78 3 9 200 142 330 8.78E-71 231 HBAP1_BOVIN reviewed HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) HSPBAP1 Bos taurus (Bovine) 484 0 GO:0005737 0 0 0 0 Q5R573 CHOYP_LOC100371074.1.1 m.36435 sp RBL2A_PONAB 70.492 183 54 0 19 201 22 204 8.78E-97 284 RBL2A_PONAB reviewed Rab-like protein 2A RABL2A Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 229 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF00071; Q5RIU9 CHOYP_LOC579990.1.1 m.10074 sp PORED_DANRE 29.773 309 196 7 4 299 8 308 8.78E-34 129 PORED_DANRE reviewed Polyprenol reductase (EC 1.3.1.94) (3-oxo-5-alpha-steroid 4-dehydrogenase 3) (EC 1.3.1.22) (Steroid 5-alpha-reductase 3) (S5AR 3) (SR type 3) srd5a3 si:ch211-278f21.3 Danio rerio (Zebrafish) (Brachydanio rerio) 309 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; dolichol metabolic process [GO:0019348]; polyprenol catabolic process [GO:0016095]; protein glycosylation [GO:0006486] GO:0003865; GO:0005783; GO:0005789; GO:0006486; GO:0006488; GO:0016021; GO:0016095; GO:0016628; GO:0019348; GO:0047751 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02544; Q5U1Z0 CHOYP_contig_019466 m.22775 sp RBGPR_RAT 37.5 72 34 1 14 74 880 951 8.78E-06 47.4 RBGPR_RAT reviewed Rab3 GTPase-activating protein non-catalytic subunit (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) Rab3gap2 Rattus norvegicus (Rat) 1386 positive regulation of autophagosome assembly [GO:2000786]; positive regulation of protein lipidation [GO:1903061]; regulation of GTPase activity [GO:0043087] GO:0005096; GO:0005737; GO:0005886; GO:0030234; GO:0043087; GO:0046982; GO:1903061; GO:2000786 0 0 0 PF14656;PF14655; Q9CQ62 CHOYP_NEMVEDRAFT_V1G235656.1.1 m.19147 sp DECR_MOUSE 64.401 309 110 0 33 341 27 335 8.78E-145 415 DECR_MOUSE reviewed "2,4-dienoyl-CoA reductase, mitochondrial (EC 1.3.1.34) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH])" Decr1 Mus musculus (Mouse) 335 fatty acid beta-oxidation [GO:0006635]; protein homotetramerization [GO:0051289] GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0006635; GO:0008670; GO:0051289; GO:0070062; GO:0070402 0 0 0 0 Q9D9T0 CHOYP_CRE_25145.1.1 m.8177 sp DYDC1_MOUSE 41.489 94 39 2 308 401 1 78 8.78E-12 67.8 DYDC1_MOUSE reviewed DPY30 domain-containing protein 1 Dydc1 Mus musculus (Mouse) 175 chromatin silencing at telomere [GO:0006348]; histone H3-K4 methylation [GO:0051568] GO:0000781; GO:0006348; GO:0048188; GO:0051568 0 0 0 PF05186; Q9H0A8 CHOYP_BRAFLDRAFT_116088.2.2 m.27531 sp COMD4_HUMAN 58.586 198 82 0 31 228 1 198 8.78E-86 255 COMD4_HUMAN reviewed COMM domain-containing protein 4 COMMD4 Homo sapiens (Human) 199 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355 0 0 0 PF07258; A4IF63 CHOYP_BRAFLDRAFT_71595.3.4 m.46267 sp TRIM2_BOVIN 25.806 124 90 1 87 210 622 743 8.79E-06 49.7 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A4IF63 CHOYP_BRAFLDRAFT_75885.6.7 m.55061 sp TRIM2_BOVIN 23.755 261 174 10 306 549 492 744 8.79E-12 71.6 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O15213 CHOYP_BRAFLDRAFT_89920.1.1 m.13963 sp WDR46_HUMAN 47.318 522 259 6 137 650 95 608 8.79E-172 506 WDR46_HUMAN reviewed WD repeat-containing protein 46 (WD repeat-containing protein BING4) WDR46 BING4 C6orf11 FP221 Homo sapiens (Human) 610 "maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; positive regulation of protein targeting to mitochondrion [GO:1903955]; rRNA processing [GO:0006364]" GO:0000462; GO:0005654; GO:0005730; GO:0006364; GO:0030686; GO:0032040; GO:0044822; GO:1903955 0 0 0 PF08149; O88281 CHOYP_LOC579946.17.24 m.53406 sp MEGF6_RAT 27.201 1147 502 56 368 1361 546 1512 8.79E-39 162 MEGF6_RAT reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Rattus norvegicus (Rat) 1574 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07645;PF12661;PF00053; P28799 CHOYP_LOC100366380.4.4 m.48501 sp GRN_HUMAN 42.029 345 171 10 19 349 189 518 8.79E-74 242 GRN_HUMAN reviewed Granulins (Proepithelin) (PEPI) [Cleaved into: Acrogranin (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Progranulin); Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)] GRN Homo sapiens (Human) 593 chondrocyte proliferation [GO:0035988]; male mating behavior [GO:0060179]; neural precursor cell proliferation [GO:0061351]; positive regulation of dendritic spine development [GO:0060999]; response to estradiol [GO:0032355]; signal transduction [GO:0007165]; synaptic vesicle endocytosis [GO:0048488] GO:0005615; GO:0007165; GO:0008083; GO:0032355; GO:0035988; GO:0043231; GO:0044822; GO:0045202; GO:0048488; GO:0060179; GO:0060999; GO:0061351; GO:0070062 0 0 0 PF00396; P36221 CHOYP_SMP_012720.2.2 m.34969 sp TBB1_NOTNE 76.526 213 46 3 10 221 57 266 8.79E-104 311 TBB1_NOTNE reviewed Tubulin beta-1 chain (Beta-1-tubulin) tubb1 Notothenia neglecta (Yellowbelly rockcod) (Notothenia coriiceps neglecta) 446 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF00091;PF03953; Q00725 CHOYP_contig_027693 m.31393 sp SGS4_DROME 48.031 127 62 2 45 171 72 194 8.79E-12 65.1 SGS4_DROME reviewed Salivary glue protein Sgs-4 Sgs4 Sgs-4 CG12181 Drosophila melanogaster (Fruit fly) 297 0 GO:0005576 0 0 0 0 Q868T3 CHOYP_CCAPR.1.2 m.40212 sp CCAPR_DROME 34.557 327 202 6 21 346 103 418 8.79E-55 190 CCAPR_DROME reviewed Cardioacceleratory peptide receptor (Crustacean cardioactive peptide receptor) CCAP-R CcapR CG33344 Drosophila melanogaster (Fruit fly) 495 "ecdysis, chitin-based cuticle [GO:0018990]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]" GO:0005000; GO:0005887; GO:0007186; GO:0007218; GO:0008188; GO:0016021; GO:0018990 0 0 0 PF00001; Q8SRI3 CHOYP_LOC100493069.1.1 m.64872 sp MRK1_ENCCU 30.263 152 95 4 179 321 35 184 8.79E-18 85.5 MRK1_ENCCU reviewed Probable serine/threonine-protein kinase MRK1 homolog (EC 2.7.11.1) MRK1 ECU07_1270 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) 318 cell division [GO:0051301]; mitotic nuclear division [GO:0007067] GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0007067; GO:0051301 0 0 0 PF00069; Q9Y2C9 CHOYP_BRAFLDRAFT_68489.1.3 m.25384 sp TLR6_HUMAN 27.893 337 201 10 61 364 450 777 8.79E-32 130 TLR6_HUMAN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) 796 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0038124; GO:0042088; GO:0042496; GO:0042742; GO:0043123; GO:0043507; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; A6QP79 CHOYP_COL12.2.3 m.48621 sp COL12_BOVIN 36.986 146 82 4 24 164 592 732 8.80E-23 97.4 COL12_BOVIN reviewed Collectin-12 (Collectin placenta protein 1) (CL-P1) COLEC12 CLP1 Bos taurus (Bovine) 742 "cellular response to exogenous dsRNA [GO:0071360]; immune response [GO:0006955]; phagocytosis, recognition [GO:0006910]; positive regulation of cell adhesion molecule production [GO:0060355]; toll-like receptor 3 signaling pathway [GO:0034138]" GO:0005581; GO:0006910; GO:0006955; GO:0008329; GO:0016021; GO:0030169; GO:0030246; GO:0034138; GO:0046872; GO:0060355; GO:0070062; GO:0071360 0 0 0 PF01391;PF00059; B3EWZ6 CHOYP_BRAFLDRAFT_66659.1.2 m.2454 sp MLRP2_ACRMI 34.513 113 67 5 2 108 752 863 8.80E-10 58.2 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; B3EWZ6 CHOYP_NEMVEDRAFT_V1G198667.8.15 m.25541 sp MLRP2_ACRMI 31.075 930 501 38 602 1472 364 1212 8.80E-89 325 MLRP2_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 2 (Skeletal organic matrix MAM and LDL-receptor 2) (SOM MAM and LDL-receptor 2) (Fragment) 0 Acropora millepora (Staghorn coral) 7311 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O43543 CHOYP_NEMVEDRAFT_V1G113922.1.1 m.15556 sp XRCC2_HUMAN 38.346 266 140 4 2 262 7 253 8.80E-58 189 XRCC2_HUMAN reviewed DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2) XRCC2 Homo sapiens (Human) 280 centrosome organization [GO:0051297]; DNA repair [GO:0006281]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair via homologous recombination [GO:0000724]; in utero embryonic development [GO:0001701]; meiotic DNA recombinase assembly [GO:0000707]; meiotic nuclear division [GO:0007126]; mitotic cell cycle [GO:0000278]; mitotic recombination [GO:0006312]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of neurogenesis [GO:0050769]; reciprocal meiotic recombination [GO:0007131]; regulation of fibroblast apoptotic process [GO:2000269]; response to gamma radiation [GO:0010332]; response to ionizing radiation [GO:0010212]; response to X-ray [GO:0010165]; somitogenesis [GO:0001756]; strand displacement [GO:0000732]; strand invasion [GO:0042148] GO:0000150; GO:0000278; GO:0000707; GO:0000724; GO:0000731; GO:0000732; GO:0001701; GO:0001756; GO:0003690; GO:0003697; GO:0005524; GO:0005654; GO:0005657; GO:0005737; GO:0005813; GO:0006281; GO:0006312; GO:0007126; GO:0007131; GO:0008094; GO:0010165; GO:0010212; GO:0010332; GO:0033063; GO:0035264; GO:0042148; GO:0043524; GO:0050769; GO:0051297; GO:2000269 0 0 0 PF08423; P30932 CHOYP_LOC594151.1.2 m.7271 sp CD9_BOVIN 27.465 142 101 2 67 207 9 149 8.80E-12 65.5 CD9_BOVIN reviewed CD9 antigen (CD antigen CD9) CD9 Bos taurus (Bovine) 226 cell adhesion [GO:0007155]; cell surface receptor signaling pathway [GO:0007166]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; fusion of sperm to egg plasma membrane [GO:0007342]; negative regulation of cell proliferation [GO:0008285]; paranodal junction assembly [GO:0030913]; receptor internalization [GO:0031623] GO:0005887; GO:0007155; GO:0007166; GO:0007342; GO:0008285; GO:0016020; GO:0030913; GO:0031623; GO:0071404 0 0 0 PF00335; P60899 CHOYP_LOC101071441.1.1 m.64484 sp RPB9_PIG 82.906 117 20 0 36 152 9 125 8.80E-72 214 RPB9_PIG reviewed DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5) POLR2I Sus scrofa (Pig) 125 maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [GO:0001193]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367] GO:0001193; GO:0003676; GO:0003899; GO:0005634; GO:0005665; GO:0005730; GO:0006283; GO:0006366; GO:0006367; GO:0008270 0 0 0 PF02150;PF01096; Q5NUA6 CHOYP_BRAFLDRAFT_127500.1.1 m.25229 sp NF2L2_BOVIN 28.613 685 358 21 174 824 12 599 8.80E-61 220 NF2L2_BOVIN reviewed "Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2)" NFE2L2 NRF2 Bos taurus (Bovine) 607 "cellular response to fluid shear stress [GO:0071498]; cellular response to oxidative stress [GO:0034599]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000976; GO:0003700; GO:0005634; GO:0005737; GO:0005829; GO:0006351; GO:0006357; GO:0010499; GO:0016567; GO:0034599; GO:0043161; GO:0045893; GO:0045944; GO:0071498 0 0 0 PF03131; Q5U584 CHOYP_3BP5L.1.1 m.23628 sp 3BP5L_XENLA 53.386 251 112 2 31 281 54 299 8.80E-79 254 3BP5L_XENLA reviewed SH3 domain-binding protein 5-like (SH3BP-5-like) sh3bp5l Xenopus laevis (African clawed frog) 373 intracellular signal transduction [GO:0035556] GO:0005622; GO:0035556 0 0 0 PF05276; Q80UJ9 CHOYP_SETMAR.1.1 m.17025 sp SETMR_MOUSE 42.199 282 146 7 14 285 32 306 8.80E-62 200 SETMR_MOUSE reviewed Histone-lysine N-methyltransferase SETMAR (EC 2.1.1.43) (SET domain without mariner transposase fusion protein) Setmar Mus musculus (Mouse) 309 "cell proliferation [GO:0008283]; DNA catabolic process, endonucleolytic [GO:0000737]; DNA double-strand break processing [GO:0000729]; DNA integration [GO:0015074]; double-strand break repair via nonhomologous end joining [GO:0006303]; histone H3-K36 dimethylation [GO:0097676]; histone H3-K36 methylation [GO:0010452]; histone H3-K4 methylation [GO:0051568]; mitotic DNA integrity checkpoint [GO:0044774]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of chromosome organization [GO:2001251]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; replication fork processing [GO:0031297]" GO:0000014; GO:0000729; GO:0000737; GO:0000793; GO:0003690; GO:0003697; GO:0005634; GO:0006303; GO:0008270; GO:0008283; GO:0010452; GO:0015074; GO:0031297; GO:0035861; GO:0042800; GO:0043566; GO:0044774; GO:0046975; GO:0051568; GO:0071157; GO:0097676; GO:2000373; GO:2001034; GO:2001251 0 0 0 PF05033;PF00856; Q8BLI0 CHOYP_MADD-4.1.1 m.33455 sp ATL1_MOUSE 28.997 369 191 6 1 301 560 925 8.80E-40 159 ATL1_MOUSE reviewed ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1) Adamtsl1 Mus musculus (Mouse) 1745 0 GO:0005578; GO:0008237; GO:0008270 0 0 0 PF07679;PF08686;PF00090; P42577 CHOYP_FRIS.3.11 m.39934 sp FRIS_LYMST 82.456 171 30 0 1 171 1 171 8.81E-104 298 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P86854 CHOYP_LOC589466.1.1 m.30470 sp PLCL_MYTGA 28.037 107 69 1 63 169 50 148 8.81E-10 59.7 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q3T149 CHOYP_DSIM_GD24875.1.1 m.66201 sp HSPB1_BOVIN 29.891 184 105 5 4 168 6 184 8.81E-16 74.3 HSPB1_BOVIN reviewed Heat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) HSPB1 HSP27 Bos taurus (Bovine) 201 0 GO:0005634; GO:0005737; GO:0005819 0 0 0 PF00011; Q6DJ48 CHOYP_STN1.1.1 m.17346 sp STN1_XENTR 33.708 356 204 13 31 364 7 352 8.81E-52 179 STN1_XENTR reviewed CST complex subunit STN1 (Oligonucleotide/oligosaccharide-binding fold-containing protein 1) (Suppressor of cdc thirteen homolog) obfc1 stn1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 368 telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via telomere lengthening [GO:0010833] GO:0000723; GO:0000784; GO:0005634; GO:0010833; GO:0016233; GO:0043047; GO:1990879 0 0 0 PF10451;PF09170; Q6P3V7 CHOYP_LOC100366770.1.1 m.55784 sp TTC41_RAT 31.79 821 488 19 15 811 4 776 8.81E-107 375 TTC41_RAT reviewed Tetratricopeptide repeat protein 41 (TPR repeat protein 41) (Grp94-neighboring nucleotidase) Ttc41 Gnn Rattus norvegicus (Rat) 1309 0 GO:0005737 0 0 0 0 Q8NET8 CHOYP_TRPV3.3.3 m.66566 sp TRPV3_HUMAN 23.782 349 216 13 28 361 338 651 8.81E-12 70.1 TRPV3_HUMAN reviewed Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3) TRPV3 Homo sapiens (Human) 790 calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to heat [GO:0009408] GO:0005262; GO:0005886; GO:0005887; GO:0009408; GO:0042636; GO:0043235; GO:0070588; GO:0090280 0 0 0 PF12796;PF00520; Q9JLC8 CHOYP_NEMVEDRAFT_V1G199235.1.15 m.3373 sp SACS_MOUSE 28.264 1256 728 47 5 1158 1190 2374 8.81E-110 383 SACS_MOUSE reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) Sacs Kiaa0730 Mus musculus (Mouse) 4582 0 GO:0005737; GO:0050750 0 0 0 PF05168; O43159 CHOYP_LOC591283.1.1 m.46566 sp RRP8_HUMAN 45.357 280 146 3 653 931 162 435 8.82E-76 258 RRP8_HUMAN reviewed Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin) RRP8 KIAA0409 NML hucep-1 Homo sapiens (Human) 456 "cellular response to glucose starvation [GO:0042149]; chromatin silencing at rDNA [GO:0000183]; covalent chromatin modification [GO:0016569]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of cell cycle arrest [GO:0071158]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0000183; GO:0005634; GO:0005654; GO:0005677; GO:0005730; GO:0005737; GO:0005886; GO:0006351; GO:0006364; GO:0008757; GO:0016569; GO:0033553; GO:0035064; GO:0042149; GO:0044822; GO:0046015; GO:0071158; GO:0072332 0 0 0 PF05148; P09593 CHOYP_LOC100535301.1.5 m.3177 sp SANT_PLAFV 37.745 204 117 3 11 214 110 303 8.82E-07 53.9 SANT_PLAFV reviewed S-antigen protein 0 Plasmodium falciparum (isolate v1) 375 0 GO:0020003 0 0 0 PF05756; P36406 CHOYP_LOC100374741.41.83 m.38994 sp TRI23_HUMAN 22.901 262 168 9 8 242 121 375 8.82E-08 57.4 TRI23_HUMAN reviewed E3 ubiquitin-protein ligase TRIM23 (EC 6.3.2.-) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (Tripartite motif-containing protein 23) TRIM23 ARD1 ARFD1 RNF46 Homo sapiens (Human) 574 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264]; viral process [GO:0016032] GO:0000139; GO:0003924; GO:0004842; GO:0005525; GO:0005634; GO:0005765; GO:0007264; GO:0008047; GO:0008270; GO:0016032; GO:0016567; GO:0016874; GO:0019003; GO:0042802; GO:0070062 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF14634; Q503I2 CHOYP_TVAG_491110.6.18 m.20460 sp TRI13_DANRE 23.047 256 153 8 33 275 52 276 8.82E-07 53.5 TRI13_DANRE reviewed Tripartite motif-containing 13 trim13 zgc:110578 Danio rerio (Zebrafish) (Brachydanio rerio) 404 protein ubiquitination [GO:0016567] GO:0005789; GO:0008270; GO:0016021; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00643;PF13445; Q8AXX2 CHOYP_BRAFLDRAFT_56662.1.1 m.14352 sp TBX1_DANRE 58.553 304 97 7 90 380 49 336 8.82E-115 348 TBX1_DANRE reviewed T-box transcription factor TBX1 (T-box protein 1) tbx1 zgc:136724 Danio rerio (Zebrafish) (Brachydanio rerio) 460 "cardiac muscle cell differentiation [GO:0055007]; cartilage morphogenesis [GO:0060536]; ear development [GO:0043583]; ear morphogenesis [GO:0042471]; embryonic heart tube morphogenesis [GO:0003143]; embryonic viscerocranium morphogenesis [GO:0048703]; heart development [GO:0007507]; heart looping [GO:0001947]; neural crest cell development [GO:0014032]; neural crest cell migration [GO:0001755]; parathyroid gland development [GO:0060017]; pharyngeal muscle development [GO:0043282]; pharyngeal system development [GO:0060037]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; semicircular canal morphogenesis [GO:0048752]; soft palate development [GO:0060023]; thymus development [GO:0048538]; transcription, DNA-templated [GO:0006351]" GO:0001755; GO:0001947; GO:0003143; GO:0003700; GO:0005634; GO:0006351; GO:0007507; GO:0014032; GO:0042471; GO:0042803; GO:0043282; GO:0043565; GO:0043583; GO:0048538; GO:0048703; GO:0048752; GO:0055007; GO:0060017; GO:0060023; GO:0060037; GO:0060536; GO:0072513 0 0 0 PF00907; Q8IVG5 CHOYP_LOC100176364.4.4 m.61033 sp SAM9L_HUMAN 24.382 283 170 10 336 597 669 928 8.82E-10 65.9 SAM9L_HUMAN reviewed Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like) SAMD9L C7orf6 DRIF2 KIAA2005 UEF Homo sapiens (Human) 1584 0 0 0 0 0 0 Q9BXJ4 CHOYP_C1QT3.6.8 m.37079 sp C1QT3_HUMAN 31.818 154 92 6 55 200 92 240 8.82E-09 57 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; A0NGI1 CHOYP_LOC100744068.1.1 m.28677 sp TM234_ANOGA 50 120 60 0 6 125 20 139 8.83E-40 132 TM234_ANOGA reviewed Transmembrane protein 234 homolog AGAP012180 Anopheles gambiae (African malaria mosquito) 140 transmembrane transport [GO:0055085] GO:0005887; GO:0022891; GO:0055085 0 0 0 PF10639; D2GXS7 CHOYP_LOC100376215.11.19 m.35422 sp TRIM2_AILME 31.092 119 79 2 57 173 627 744 8.83E-07 51.2 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O75382 CHOYP_BRAFLDRAFT_75885.1.7 m.32525 sp TRIM3_HUMAN 25.641 234 132 11 147 361 534 744 8.83E-09 60.8 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; O93530 CHOYP_WRN.1.1 m.253 sp WRN_XENLA 43.496 246 114 4 24 267 5 227 8.83E-56 196 WRN_XENLA reviewed Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-) (Focus-forming activity 1) (FFA-1) wrn ffa1 Xenopus laevis (African clawed frog) 1436 DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] GO:0000287; GO:0003677; GO:0005524; GO:0005634; GO:0006259; GO:0006260; GO:0006281; GO:0006310; GO:0008408; GO:0030145; GO:0043140 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; P21941 CHOYP_LOC591293.1.1 m.33295 sp MATN1_HUMAN 34.634 205 118 5 62 261 268 461 8.83E-28 121 MATN1_HUMAN reviewed Cartilage matrix protein (Matrilin-1) MATN1 CMP CRTM Homo sapiens (Human) 496 extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein complex assembly [GO:0006461]; regulation of bone mineralization [GO:0030500] GO:0003429; GO:0005201; GO:0005509; GO:0005576; GO:0005578; GO:0006461; GO:0030198; GO:0030500 0 0 0 PF10393;PF00092; P61917 CHOYP_NPC2.6.7 m.31030 sp NPC2_PANTR 40.441 136 74 3 14 144 16 149 8.83E-30 108 NPC2_PANTR reviewed Epididymal secretory protein E1 (EPI-1) (Niemann Pick type C2 protein homolog) NPC2 Pan troglodytes (Chimpanzee) 151 cholesterol efflux [GO:0033344]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; intracellular cholesterol transport [GO:0032367]; response to virus [GO:0009615] GO:0005764; GO:0005783; GO:0008203; GO:0009615; GO:0015485; GO:0030301; GO:0032367; GO:0033344; GO:0042632; GO:0070062 0 0 0 PF02221; P86948 CHOYP_MP.3.4 m.11534 sp MP_PINMA 40.53 264 130 4 1 255 1 246 8.83E-42 149 MP_PINMA reviewed Mantle protein (MP) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 260 0 GO:0005576 0 0 0 0 Q03412 CHOYP_LOC100533354.4.6 m.59053 sp UNC7_CAEEL 34.4 375 225 6 25 389 138 501 8.83E-78 253 UNC7_CAEEL reviewed Innexin unc-7 (Uncoordinated protein 7) unc-7 unc-12 unc-124 R07D5.1 Caenorhabditis elegans 522 gap junction assembly [GO:0016264]; ion transmembrane transport [GO:0034220]; locomotion [GO:0040011]; oviposition [GO:0018991]; regulation of pharyngeal pumping [GO:0043051]; response to anesthetic [GO:0072347] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0016264; GO:0018991; GO:0032589; GO:0034220; GO:0040011; GO:0043051; GO:0055077; GO:0072347 0 0 0 PF00876; Q05481 CHOYP_ZNF595.1.1 m.7083 sp ZNF91_HUMAN 37.56 418 229 7 71 477 313 709 8.83E-79 272 ZNF91_HUMAN reviewed Zinc finger protein 91 (Zinc finger protein HPF7) (Zinc finger protein HTF10) ZNF91 Homo sapiens (Human) 1191 "negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transposon integration [GO:0070895]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0008270; GO:0045892; GO:0070895 0 0 cd07765; PF01352;PF00096;PF13912; Q3HNG7 CHOYP_BRAFLDRAFT_190162.1.5 m.1708 sp H1FOO_BOVIN 40.909 66 39 0 44 109 48 113 8.83E-11 63.9 H1FOO_BOVIN reviewed Histone H1oo (Oocyte-specific histone H1) (Oocyte-specific linker histone H1) H1FOO H1OO Bos taurus (Bovine) 343 meiotic cell cycle [GO:0051321]; negative regulation of stem cell differentiation [GO:2000737]; nucleosome assembly [GO:0006334]; nucleosome positioning [GO:0016584]; regulation of DNA methylation [GO:0044030] GO:0000786; GO:0005634; GO:0005737; GO:0006334; GO:0016584; GO:0031492; GO:0044030; GO:0051321; GO:2000737 0 0 0 PF00538; Q5UR67 CHOYP_STERM_3136.1.1 m.53971 sp RIBX_MIMIV 42.759 145 78 2 313 452 21 165 8.83E-29 115 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q5XNR9 CHOYP_LOC100019437.1.1 m.56269 sp LIFR_CANLF 21.447 387 247 15 119 485 326 675 8.83E-06 53.5 LIFR_CANLF reviewed Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118) LIFR Canis lupus familiaris (Dog) (Canis familiaris) 1097 positive regulation of cell proliferation [GO:0008284] GO:0004923; GO:0004924; GO:0005886; GO:0008284; GO:0016021; GO:0043235; GO:0070062 0 0 0 PF00041; Q92886 CHOYP_NEUROG2-A.1.1 m.29764 sp NGN1_HUMAN 52.041 98 35 2 88 185 84 169 8.83E-24 100 NGN1_HUMAN reviewed Neurogenin-1 (NGN-1) (Class A basic helix-loop-helix protein 6) (bHLHa6) (Neurogenic basic-helix-loop-helix protein) (Neurogenic differentiation factor 3) (NeuroD3) NEUROG1 BHLHA6 NEUROD3 NGN NGN1 Homo sapiens (Human) 237 "cell fate commitment [GO:0045165]; inner ear morphogenesis [GO:0042472]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000989; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0006351; GO:0006357; GO:0007399; GO:0030182; GO:0031536; GO:0042472; GO:0043204; GO:0045165; GO:0045666; GO:0045944; GO:0051091; GO:0070888 0 0 0 PF00010; Q96KF7 CHOYP_LOC100175393.1.1 m.20280 sp SMIM8_HUMAN 40.659 91 51 2 12 100 8 97 8.83E-16 69.3 SMIM8_HUMAN reviewed Small integral membrane protein 8 SMIM8 C6orf162 DC18 Homo sapiens (Human) 97 0 GO:0016021 0 0 0 PF14937; Q9I8M9 CHOYP_LOC100871815.1.1 m.18412 sp TWS1B_XENLA 39.269 219 122 7 1 211 1 216 8.83E-44 151 TWS1B_XENLA reviewed Twisted gastrulation protein homolog 1-B twsg1-b tsg Xenopus laevis (African clawed frog) 218 multicellular organism development [GO:0007275] GO:0005576; GO:0007275 0 0 0 PF04668; Q9NZ56 CHOYP_PHUM_PHUM602670.1.1 m.52487 sp FMN2_HUMAN 29.412 442 281 12 433 858 1263 1689 8.83E-43 176 FMN2_HUMAN reviewed Formin-2 FMN2 Homo sapiens (Human) 1722 cellular response to DNA damage stimulus [GO:0006974]; cellular response to hypoxia [GO:0071456]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; homologous chromosome movement towards spindle pole involved in homologous chromosome segregation [GO:0051758]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein catabolic process [GO:0042177]; oogenesis [GO:0048477]; polar body extrusion after meiotic divisions [GO:0040038]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192] GO:0003779; GO:0005730; GO:0005789; GO:0005819; GO:0005829; GO:0005886; GO:0005902; GO:0005938; GO:0006974; GO:0007275; GO:0015031; GO:0016192; GO:0030659; GO:0035556; GO:0040038; GO:0042177; GO:0043066; GO:0046907; GO:0048471; GO:0048477; GO:0051295; GO:0051758; GO:0070649; GO:0071456 0 0 0 PF06346;PF02181; Q9Y2X8 CHOYP_UB2D4.1.1 m.23005 sp UB2D4_HUMAN 79.2 125 25 1 1 125 1 124 8.83E-69 206 UB2D4_HUMAN reviewed Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4) UBE2D4 UBCH5D Homo sapiens (Human) 147 protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein K6-linked ubiquitination [GO:0085020]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005524; GO:0016567; GO:0035519; GO:0044314; GO:0061631; GO:0070534; GO:0070936; GO:0070979; GO:0085020 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; O35276 CHOYP_LOC101242716.1.1 m.14899 sp NRP2_RAT 27.397 146 94 6 15 152 1 142 8.84E-09 61.2 NRP2_RAT reviewed Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) Nrp2 Rattus norvegicus (Rat) 925 angiogenesis [GO:0001525]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; dorsal root ganglion morphogenesis [GO:1904835]; facial nerve structural organization [GO:0021612]; facioacoustic ganglion development [GO:1903375]; gonadotrophin-releasing hormone neuronal migration to the hypothalamus [GO:0021828]; heart development [GO:0007507]; negative chemotaxis [GO:0050919]; neural crest cell migration involved in autonomic nervous system development [GO:1901166]; semaphorin-plexin signaling pathway involved in neuron projection guidance [GO:1902285]; sensory neuron axon guidance [GO:0097374]; sympathetic ganglion development [GO:0061549]; sympathetic neuron projection extension [GO:0097490]; sympathetic neuron projection guidance [GO:0097491]; trigeminal ganglion development [GO:0061551]; ventral trunk neural crest cell migration [GO:0036486]; vestibulocochlear nerve structural organization [GO:0021649] GO:0001525; GO:0005021; GO:0007411; GO:0007507; GO:0008201; GO:0016021; GO:0017154; GO:0021612; GO:0021649; GO:0021828; GO:0030424; GO:0036486; GO:0046872; GO:0048846; GO:0050919; GO:0061549; GO:0061551; GO:0097374; GO:0097490; GO:0097491; GO:1901166; GO:1902285; GO:1903375; GO:1904835 0 0 cd06263; PF00431;PF11980;PF00754;PF00629; P24044 CHOYP_CALM.43.50 m.56680 sp CALM_PLAFA 46.575 146 76 1 21 166 5 148 8.84E-38 129 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; Q04870 CHOYP_LOC100740578.1.1 m.65702 sp T2FA_XENLA 39.474 532 250 16 83 570 20 523 8.84E-80 263 T2FA_XENLA reviewed General transcription factor IIF subunit 1 (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74) gtf2f1 rap74 Xenopus laevis (African clawed frog) 524 positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; transcription initiation from RNA polymerase II promoter [GO:0006367] GO:0003677; GO:0005634; GO:0006367; GO:0016740; GO:0032968 0 0 0 PF05793; Q20026 CHOYP_CTL1L.1.1 m.15511 sp CTL1L_CAEEL 33.835 133 77 5 1 128 147 273 8.84E-12 64.3 CTL1L_CAEEL reviewed Choline transporter-like protein 1 chtl-1 F35C8.7 Caenorhabditis elegans 771 0 GO:0016021 0 0 0 PF04515; Q5G872 CHOYP_LOC577317.1.1 m.65926 sp SCUB2_DANRE 46.903 226 116 1 27 248 265 490 8.84E-62 212 SCUB2_DANRE reviewed "Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein You)" scube2 you Danio rerio (Zebrafish) (Brachydanio rerio) 1010 blood circulation [GO:0008015]; muscle cell fate specification [GO:0042694]; muscle fiber development [GO:0048747]; muscle organ development [GO:0007517]; smoothened signaling pathway [GO:0007224]; somitogenesis [GO:0001756]; striated muscle cell differentiation [GO:0051146] GO:0001756; GO:0005509; GO:0005576; GO:0005615; GO:0007224; GO:0007517; GO:0008015; GO:0009897; GO:0009986; GO:0030141; GO:0042694; GO:0048747; GO:0051146 0 0 0 PF12662;PF00431;PF12947;PF07645;PF07699; Q6AZB8 CHOYP_LOC100491442.2.2 m.55896 sp HARB1_DANRE 41.096 146 82 1 5 146 161 306 8.84E-34 125 HARB1_DANRE reviewed Putative nuclease HARBI1 (EC 3.1.-.-) (Harbinger transposase-derived nuclease) harbi1 zgc:91866 Danio rerio (Zebrafish) (Brachydanio rerio) 349 0 GO:0004518; GO:0005634; GO:0005737; GO:0046872 0 0 0 PF13359; Q6PFY8 CHOYP_LOC100374981.8.16 m.43018 sp TRI45_MOUSE 25.157 159 107 4 1 156 150 299 8.84E-06 51.2 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8R0X2 CHOYP_CACUL1.1.1 m.54980 sp CACL1_MOUSE 48.523 237 117 2 37 273 131 362 8.84E-79 246 CACL1_MOUSE reviewed CDK2-associated and cullin domain-containing protein 1 Cacul1 Mus musculus (Mouse) 377 G1/S transition of mitotic cell cycle [GO:0000082]; positive regulation of cell proliferation [GO:0008284]; positive regulation of protein kinase activity [GO:0045860]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000082; GO:0005680; GO:0008284; GO:0019901; GO:0031625; GO:0042787; GO:0045860 0 0 0 PF00888; Q96NS5 CHOYP_ASB16.1.1 m.11360 sp ASB16_HUMAN 28.617 311 184 12 52 351 166 449 8.84E-13 72.4 ASB16_HUMAN reviewed Ankyrin repeat and SOCS box protein 16 (ASB-16) ASB16 Homo sapiens (Human) 453 intracellular signal transduction [GO:0035556] GO:0000151; GO:0004842; GO:0005634; GO:0005737; GO:0031625; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q9ESN6 CHOYP_BRAFLDRAFT_102380.6.11 m.33619 sp TRIM2_MOUSE 25.806 248 164 10 87 321 491 731 8.84E-09 60.1 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9GZZ6 CHOYP_ACH7.1.2 m.64204 sp ACH10_HUMAN 26.573 429 278 10 170 576 34 447 8.84E-39 151 ACH10_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 NACHRA10 Homo sapiens (Human) 450 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; regulation of cell proliferation [GO:0042127]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005102; GO:0005262; GO:0005892; GO:0007165; GO:0007204; GO:0007271; GO:0016020; GO:0030054; GO:0030424; GO:0042127; GO:0042166; GO:0042472; GO:0043204; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; Q9HCI5 CHOYP_FIBH.1.1 m.66800 sp MAGE1_HUMAN 32.584 178 113 1 648 818 211 388 8.84E-15 82.8 MAGE1_HUMAN reviewed Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen) MAGEE1 HCA1 KIAA1587 Homo sapiens (Human) 957 0 GO:0005634; GO:0005886; GO:0016010; GO:0030425; GO:0045211; GO:0048471 0 0 0 PF01454; Q9NZJ4 CHOYP_BRAFLDRAFT_67666.5.6 m.55319 sp SACS_HUMAN 25.854 2460 1559 84 3 2273 2107 4490 8.84E-177 610 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9R045 CHOYP_FGL1.1.6 m.30450 sp ANGL2_MOUSE 39.924 263 137 4 482 742 244 487 8.84E-53 193 ANGL2_MOUSE reviewed Angiopoietin-related protein 2 (Angiopoietin-like protein 2) Angptl2 Arp2 Mus musculus (Mouse) 493 0 GO:0070062 0 0 0 PF00147; A0JNH9 CHOYP_LOC100368976.1.1 m.1873 sp APLF_BOVIN 38.125 160 73 5 488 632 337 485 8.85E-17 87 APLF_BOVIN reviewed Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) APLF Bos taurus (Bovine) 485 cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; single strand break repair [GO:0000012] GO:0000012; GO:0000166; GO:0003906; GO:0004520; GO:0005634; GO:0005829; GO:0006302; GO:0006974; GO:0008408; GO:0046872 0 0 0 PF10283; A7LCJ2 CHOYP_LOC100893270.2.3 m.29083 sp PA2_URTCR 37.719 114 65 4 26 136 40 150 8.85E-17 75.5 PA2_URTCR reviewed Phospholipase A2 A2-actitoxin-Ucs2a (A2-AITX-Ucs2a) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) (UcPLA2) 0 Urticina crassicornis (Mottled anemone) (Tealia crassicornis) 155 lipid catabolic process [GO:0016042] GO:0004623; GO:0005509; GO:0005576; GO:0016042; GO:0042151 0 0 0 PF00068; O61463 CHOYP_RLA2.6.9 m.23018 sp RLA2_CRYST 56.989 93 38 1 9 101 20 110 8.85E-18 75.1 RLA2_CRYST reviewed 60S acidic ribosomal protein P2 0 Cryptochiton stelleri (Giant gumboot chiton) 110 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 P14198 CHOYP_CAOG_08159.1.2 m.59739 sp AAC4_DICDI 39.13 184 101 4 58 231 496 678 8.85E-32 125 AAC4_DICDI reviewed AAC-rich mRNA clone AAC4 protein AAC4 DDB_G0267458 Dictyostelium discoideum (Slime mold) 678 0 GO:0016021 0 0 0 0 Q02844 CHOYP_BRAFLDRAFT_123738.1.1 m.44181 sp TRYB1_MOUSE 38.745 271 129 11 323 584 23 265 8.85E-43 158 TRYB1_MOUSE reviewed Tryptase (EC 3.4.21.59) (Mast cell protease 7) (mMCP-7) (Tryptase alpha/beta-1) Tpsab1 Mcpt7 Mus musculus (Mouse) 273 0 GO:0004252 0 0 cd00190; PF00089; Q06852 CHOYP_DVIR_GJ11408.1.1 m.53082 sp SLAP1_CLOTH 52.374 653 172 49 12 598 1431 2010 8.85E-26 117 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q3UHR0 CHOYP_LOC100369237.3.3 m.48902 sp BAHC1_MOUSE 57.803 173 72 1 2035 2207 2462 2633 8.85E-59 229 BAHC1_MOUSE reviewed BAH and coiled-coil domain-containing protein 1 Bahcc1 Kiaa1447 Mus musculus (Mouse) 2643 chromatin silencing [GO:0006342]; heterochromatin assembly [GO:0031507] GO:0000785; GO:0000976; GO:0003682; GO:0005677; GO:0006342; GO:0031507 0 0 0 PF01426; Q5BKL8 CHOYP_contig_020223 m.23458 sp XIAP_XENTR 27.049 122 72 2 102 206 268 389 8.85E-06 49.3 XIAP_XENTR reviewed E3 ubiquitin-protein ligase XIAP (EC 6.3.2.-) (Baculoviral IAP repeat-containing protein 4) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 492 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of proteolysis [GO:0045861]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055] GO:0004842; GO:0005634; GO:0005737; GO:0007275; GO:0008270; GO:0016055; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0045861; GO:0090263; GO:1990001 0 0 0 PF00653; Q5M9B1 CHOYP_BRAFLDRAFT_118668.3.3 m.60266 sp SPSB3_XENLA 35.468 203 124 4 61 262 115 311 8.85E-33 125 SPSB3_XENLA reviewed SPRY domain-containing SOCS box protein 3 (SSB-3) spsb3 Xenopus laevis (African clawed frog) 360 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07525;PF00622; Q5UR69 CHOYP_LOC100890951.1.1 m.38610 sp YL615_MIMIV 29.412 102 50 4 6 98 29 117 8.85E-08 57.8 YL615_MIMIV reviewed Putative phosphatidylinositol kinase L615 (EC 2.7.1.-) MIMI_L615 Acanthamoeba polyphaga mimivirus (APMV) 701 phosphatidylinositol-mediated signaling [GO:0048015]; phosphatidylinositol phosphorylation [GO:0046854] GO:0016301; GO:0046854; GO:0046872; GO:0048015 0 0 0 PF01363;PF00454; Q92125 CHOYP_LOC100372219.1.1 m.11590 sp ANXA7_XENLA 40.669 359 179 3 186 544 188 512 8.85E-75 249 ANXA7_XENLA reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) anxa7 anx7 Xenopus laevis (African clawed frog) 512 0 GO:0005509; GO:0005544 0 0 0 PF00191; Q96GP6 CHOYP_BRAFLDRAFT_224574.11.18 m.45625 sp SREC2_HUMAN 38.889 216 119 9 182 397 231 433 8.85E-28 120 SREC2_HUMAN reviewed Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) SCARF2 SREC2 SREPCR Homo sapiens (Human) 870 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005925; GO:0007157; GO:0016021 0 0 0 0 Q9NSI2 CHOYP_FAM207A.1.2 m.19431 sp F207A_HUMAN 28.934 197 120 5 1 177 1 197 8.85E-14 70.1 F207A_HUMAN reviewed Protein FAM207A FAM207A C21orf70 PRED56 Homo sapiens (Human) 230 0 0 0 0 0 0 Q9VZW5 CHOYP_DPER_GL27047.1.1 m.51184 sp FMAR_DROME 24.759 311 198 10 38 332 111 401 8.85E-14 76.3 FMAR_DROME reviewed FMRFamide receptor (DFR) (DrmFMRFa-R) (Larval opioid receptor) FR FMRFaR CG2114 Drosophila melanogaster (Fruit fly) 549 adult locomotory behavior [GO:0008344]; behavioral defense response [GO:0002209]; G-protein coupled receptor signaling pathway [GO:0007186]; larval locomotory behavior [GO:0008345]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytosolic calcium ion concentration [GO:0007204] GO:0001653; GO:0002209; GO:0004930; GO:0005887; GO:0007186; GO:0007204; GO:0007218; GO:0008188; GO:0008344; GO:0008345; GO:0016021 0 0 0 PF10324; P41996 CHOYP_SP79.1.1 m.40272 sp CPG2_CAEEL 26.543 162 105 2 47 208 154 301 8.86E-07 55.5 CPG2_CAEEL reviewed Chondroitin proteoglycan-2 (Cytokinesis protein B0280.5) cpg-2 B0280.5 Caenorhabditis elegans 524 chitin metabolic process [GO:0006030]; eggshell formation [GO:0030703]; embryo development [GO:0009790]; mitotic cytokinesis [GO:0000281]; regulation of cytokinesis [GO:0032465] GO:0000281; GO:0005576; GO:0006030; GO:0008061; GO:0009790; GO:0030703; GO:0032465 0 0 0 PF01607; P54315 CHOYP_PNLIPRP3.1.3 m.4067 sp LIPR1_HUMAN 35.477 451 260 11 45 479 16 451 8.86E-79 256 LIPR1_HUMAN reviewed Inactive pancreatic lipase-related protein 1 (PL-RP1) PNLIPRP1 PLRP1 Homo sapiens (Human) 467 lipid metabolic process [GO:0006629] GO:0004806; GO:0005509; GO:0005576; GO:0006629 0 0 0 PF00151;PF01477; Q6AXX1 CHOYP_LOC100556662.1.1 m.53249 sp SLNL1_RAT 44.767 172 83 7 159 323 221 387 8.86E-35 134 SLNL1_RAT reviewed Schlafen-like protein 1 Slfnl1 Rattus norvegicus (Rat) 414 0 GO:0005524 0 0 0 PF04326; Q7JUX9 CHOYP_LOC100883239.1.1 m.27008 sp MRRP1_DROME 23.574 263 182 11 85 339 120 371 8.86E-13 72.4 MRRP1_DROME reviewed Mitochondrial ribonuclease P protein 1 homolog (Mitochondrial RNase P protein 1) (EC 2.1.1.-) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (tRNA methyltransferase 10 homolog C) trmt10c CG5190 Drosophila melanogaster (Fruit fly) 446 tRNA processing [GO:0008033] GO:0005739; GO:0008033; GO:0008168 0 0 0 PF01746; Q8VBX4 CHOYP_LOC100717459.1.1 m.35236 sp CLC4K_MOUSE 28.177 181 113 6 47 219 153 324 8.86E-13 69.3 CLC4K_MOUSE reviewed C-type lectin domain family 4 member K (Langerin) (CD antigen CD207) Cd207 Clec4k Mus musculus (Mouse) 331 defense response to virus [GO:0051607] GO:0005887; GO:0030246; GO:0051607 0 0 0 PF00059; Q95T19 CHOYP_DWIL_GK11931.1.1 m.14414 sp SLIMP_DROME 28.571 406 273 9 53 451 39 434 8.86E-40 152 SLIMP_DROME reviewed Serine--tRNA synthetase-like protein Slimp (Seryl-tRNA synthetase-like insect mitochondrial protein) Slimp CG31133 Drosophila melanogaster (Fruit fly) 464 cellular respiration [GO:0045333]; mitochondrion morphogenesis [GO:0070584] GO:0000049; GO:0000166; GO:0005739; GO:0045333; GO:0070584 0 0 0 PF02403; Q9HC62 CHOYP_LOC100633732.2.3 m.39658 sp SENP2_HUMAN 22.778 180 120 7 236 399 411 587 8.86E-06 51.6 SENP2_HUMAN reviewed Sentrin-specific protease 2 (EC 3.4.22.68) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 Homo sapiens (Human) 589 "dorsal/ventral axis specification [GO:0009950]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; labyrinthine layer development [GO:0060711]; mRNA transport [GO:0051028]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of DNA endoreduplication [GO:0032875]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of Wnt signaling pathway [GO:0030111]; spongiotrophoblast layer development [GO:0060712]; trophoblast giant cell differentiation [GO:0060707]; Wnt signaling pathway [GO:0016055]" GO:0001934; GO:0004175; GO:0005643; GO:0005654; GO:0007507; GO:0009950; GO:0015031; GO:0016055; GO:0016605; GO:0016925; GO:0016926; GO:0016929; GO:0030111; GO:0031397; GO:0031398; GO:0031410; GO:0031648; GO:0031965; GO:0032091; GO:0032875; GO:0035562; GO:0043518; GO:0045444; GO:0045944; GO:0051028; GO:0060707; GO:0060711; GO:0060712; GO:0070139; GO:2000045 0 0 0 PF02902; Q9WTN5 CHOYP_TPCN3.1.1 m.59086 sp TPC1_RAT 29.475 648 379 18 33 646 196 799 8.86E-64 229 TPC1_RAT reviewed Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1) Tpcn1 Tpc1 Rattus norvegicus (Rat) 817 membrane depolarization during action potential [GO:0086010] GO:0005245; GO:0005765; GO:0005886; GO:0010008; GO:0016021; GO:0072345; GO:0086010 0 0 0 PF00520; Q9Y2T5 CHOYP_LOC100877472.1.1 m.8292 sp GPR52_HUMAN 26.623 308 198 12 6 296 43 339 8.86E-16 80.1 GPR52_HUMAN reviewed Probable G-protein coupled receptor 52 GPR52 Homo sapiens (Human) 361 "adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; G-protein coupled receptor signaling pathway [GO:0007186]; learning [GO:0007612]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; synaptic transmission, dopaminergic [GO:0001963]" GO:0001588; GO:0001963; GO:0004930; GO:0005887; GO:0007186; GO:0007191; GO:0007612; GO:0035240; GO:0060158 0 0 0 PF00001; A6QLQ8 CHOYP_BRAFLDRAFT_75913.1.1 m.19374 sp ENDOU_BOVIN 36.939 379 193 10 13 348 14 389 8.87E-79 250 ENDOU_BOVIN reviewed Poly(U)-specific endoribonuclease (EC 3.1.-.-) (Protein endoU) (Uridylate-specific endoribonuclease) ENDOU Bos taurus (Bovine) 413 female pregnancy [GO:0007565]; immune response [GO:0006955] GO:0003723; GO:0004521; GO:0005044; GO:0005576; GO:0005737; GO:0006955; GO:0007565; GO:0008236; GO:0030247; GO:0046872 0 0 0 PF01033;PF09412; O14448 CHOYP_LOC100367506.1.1 m.9568 sp KAPR_MAGO7 22.881 236 153 9 182 409 163 377 8.87E-08 58.9 KAPR_MAGO7 reviewed cAMP-dependent protein kinase regulatory subunit (PKA regulatory subunit) SUM1 RPKA MGG_07335 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) 390 negative regulation of meiotic cell cycle [GO:0051447]; positive regulation of protein export from nucleus [GO:0046827] GO:0005634; GO:0005829; GO:0005952; GO:0008603; GO:0030552; GO:0046827; GO:0051447 0 0 0 PF00027; P05689 CHOYP_MGC82409.1.1 m.44657 sp CATZ_BOVIN 72.941 255 67 1 12 266 52 304 8.87E-141 400 CATZ_BOVIN reviewed Cathepsin Z (EC 3.4.18.1) CTSZ Bos taurus (Bovine) 304 proteolysis involved in cellular protein catabolic process [GO:0051603] GO:0004197; GO:0005615; GO:0005764; GO:0051603 0 0 0 PF00112; P16157 CHOYP_TVAG_168010.16.45 m.36567 sp ANK1_HUMAN 31.735 438 248 3 394 798 339 758 8.87E-54 207 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P25067 CHOYP_CO8A2.2.2 m.63533 sp CO8A2_HUMAN 35.484 124 72 5 77 195 580 700 8.87E-13 69.3 CO8A2_HUMAN reviewed Collagen alpha-2(VIII) chain (Endothelial collagen) COL8A2 Homo sapiens (Human) 703 angiogenesis [GO:0001525]; camera-type eye morphogenesis [GO:0048593]; collagen catabolic process [GO:0030574]; epithelial cell proliferation [GO:0050673]; extracellular matrix organization [GO:0030198]; single organismal cell-cell adhesion [GO:0016337] GO:0001525; GO:0005201; GO:0005576; GO:0005578; GO:0005581; GO:0005604; GO:0005788; GO:0016337; GO:0030198; GO:0030574; GO:0030674; GO:0048593; GO:0050673 0 0 0 PF00386;PF01391; Q03164 CHOYP_LOC100377495.1.1 m.17707 sp KMT2A_HUMAN 44.295 149 67 6 723 865 1057 1195 8.87E-22 106 KMT2A_HUMAN reviewed Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1 Homo sapiens (Human) 3969 "anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; circadian regulation of gene expression [GO:0032922]; definitive hemopoiesis [GO:0060216]; DNA methylation [GO:0006306]; embryonic hemopoiesis [GO:0035162]; exploration behavior [GO:0035640]; histone H3-K4 dimethylation [GO:0044648]; histone H3-K4 methylation [GO:0051568]; histone H3-K4 trimethylation [GO:0080182]; histone H4-K16 acetylation [GO:0043984]; homeostasis of number of cells within a tissue [GO:0048873]; membrane depolarization [GO:0051899]; negative regulation of cell proliferation [GO:0008285]; peptidyl-lysine monomethylation [GO:0018026]; positive regulation of cellular response to drug [GO:2001040]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transporter activity [GO:0032411]; post-embryonic development [GO:0009791]; protein complex assembly [GO:0006461]; regulation of histone H3-K14 acetylation [GO:0071440]; regulation of histone H3-K27 acetylation [GO:1901674]; regulation of histone H3-K9 acetylation [GO:2000615]; regulation of short-term neuronal synaptic plasticity [GO:0048172]; response to potassium ion [GO:0035864]; spleen development [GO:0048536]; transcription from RNA polymerase II promoter [GO:0006366]; visual learning [GO:0008542]" GO:0001046; GO:0003680; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0006306; GO:0006366; GO:0006461; GO:0006915; GO:0008270; GO:0008285; GO:0008542; GO:0009791; GO:0009952; GO:0018024; GO:0018026; GO:0032411; GO:0032922; GO:0035097; GO:0035162; GO:0035640; GO:0035864; GO:0042800; GO:0042802; GO:0042803; GO:0043984; GO:0044212; GO:0044648; GO:0045322; GO:0045893; GO:0045944; GO:0048172; GO:0048536; GO:0048873; GO:0051568; GO:0051571; GO:0051899; GO:0060216; GO:0070577; GO:0071339; GO:0071440; GO:0080182; GO:1901674; GO:2000615; GO:2001040 0 0 0 PF05965;PF05964;PF00628;PF00856;PF02008; Q08BI9 CHOYP_SYFA.1.1 m.53257 sp MCU_DANRE 50.667 300 137 4 31 328 86 376 8.87E-104 311 MCU_DANRE reviewed "Calcium uniporter protein, mitochondrial" mcu zgc:153607 Danio rerio (Zebrafish) (Brachydanio rerio) 376 actin filament organization [GO:0007015]; calcium ion transmembrane import into mitochondrion [GO:0036444]; calcium-mediated signaling [GO:0019722]; chordate embryonic development [GO:0043009]; convergent extension involved in gastrulation [GO:0060027]; glucose homeostasis [GO:0042593]; mitochondrial calcium ion homeostasis [GO:0051560]; mitochondrial calcium ion transport [GO:0006851]; positive regulation of insulin secretion [GO:0032024]; positive regulation of mitochondrial calcium ion concentration [GO:0051561]; protein complex oligomerization [GO:0035786]; regulation of heart contraction [GO:0008016] GO:0005262; GO:0005743; GO:0006851; GO:0007015; GO:0008016; GO:0015292; GO:0019722; GO:0031305; GO:0032024; GO:0034704; GO:0035786; GO:0036444; GO:0042593; GO:0043009; GO:0051560; GO:0051561; GO:0060027; GO:1990246 0 0 0 PF04678; Q5RFZ7 CHOYP_F167A.2.2 m.35605 sp F167A_DANRE 42.623 183 76 8 47 203 24 203 8.87E-30 112 F167A_DANRE reviewed Protein FAM167A fam167a si:ch211-261f7.2 Danio rerio (Zebrafish) (Brachydanio rerio) 204 0 0 0 0 0 PF11652; Q6AXQ2 CHOYP_LOC100369388.1.1 m.26058 sp EFC11_RAT 44.521 146 78 1 23 168 15 157 8.87E-38 130 EFC11_RAT reviewed EF-hand calcium-binding domain-containing protein 11 Efcab11 Rattus norvegicus (Rat) 162 0 GO:0005509 0 0 0 PF13499;PF13833; Q6PBN2 CHOYP_AIDA.1.2 m.12115 sp AIDA_DANRE 51.056 284 130 3 17 292 14 296 8.87E-88 267 AIDA_DANRE reviewed "Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)" aida zgc:73327 Danio rerio (Zebrafish) (Brachydanio rerio) 303 determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; negative regulation of determination of dorsal identity [GO:2000016]; negative regulation of JNK cascade [GO:0046329]; negative regulation of JUN kinase activity [GO:0043508]; regulation of protein homodimerization activity [GO:0043496] GO:0009953; GO:0016020; GO:0035091; GO:0043496; GO:0043508; GO:0046329; GO:0048264; GO:2000016 0 0 0 PF14186;PF08910; Q6PGS5 CHOYP_BRAFLDRAFT_92202.2.2 m.42563 sp TM56B_XENLA 34 100 66 0 20 119 15 114 8.87E-18 79.7 TM56B_XENLA reviewed Transmembrane protein 56-B tmem56-b Xenopus laevis (African clawed frog) 262 0 GO:0016021 0 0 0 PF03798; Q7JQD3 CHOYP_LOC100371249.1.1 m.63118 sp GELS1_LUMTE 62.692 260 92 4 1 257 5 262 8.87E-110 325 GELS1_LUMTE reviewed Gelsolin-like protein 1 (Actin-modulator) (EWAM) (EWAM-P1) AM Lumbricus terrestris (Common earthworm) 367 actin filament capping [GO:0051693]; actin filament fragmentation [GO:0030043]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; multicellular organism development [GO:0007275] GO:0003779; GO:0005509; GO:0005737; GO:0005856; GO:0007275; GO:0030041; GO:0030043; GO:0045010; GO:0051014; GO:0051693 0 0 0 PF00626; Q86YF9 CHOYP_LOC100375191.1.2 m.9220 sp DZIP1_HUMAN 36.949 295 162 6 39 316 58 345 8.87E-49 190 DZIP1_HUMAN reviewed Zinc finger protein DZIP1 (DAZ-interacting protein 1/2) DZIP1 DZIP DZIP2 KIAA0996 Homo sapiens (Human) 867 cilium assembly [GO:0042384]; cytoplasmic sequestering of protein [GO:0051220]; establishment of protein localization [GO:0045184]; germ cell development [GO:0007281]; multicellular organism development [GO:0007275]; smoothened signaling pathway [GO:0007224]; spermatogenesis [GO:0007283] GO:0005634; GO:0005654; GO:0005737; GO:0005814; GO:0005815; GO:0007224; GO:0007275; GO:0007281; GO:0007283; GO:0036064; GO:0042384; GO:0045184; GO:0046872; GO:0051220; GO:0097539 0 0 0 PF13815; Q8VIK5 CHOYP_MEG10.56.91 m.47515 sp PEAR1_MOUSE 40.994 161 85 7 69 226 476 629 8.87E-23 99.4 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q91WV7 CHOYP_SLC31.5.5 m.57886 sp SLC31_MOUSE 33.107 589 332 22 42 591 85 650 8.87E-85 281 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q9ESN6 CHOYP_TRIM3.46.58 m.47070 sp TRIM2_MOUSE 30.22 182 109 9 93 268 536 705 8.87E-11 65.5 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A3KG59 CHOYP_P20D2.1.2 m.9005 sp P20D2_MOUSE 46.192 407 206 7 2 397 18 422 8.88E-110 332 P20D2_MOUSE reviewed Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2) Pm20d2 Acy1l2 Gm424 Mus musculus (Mouse) 431 proteolysis [GO:0006508]; regulation of cellular protein metabolic process [GO:0032268] GO:0005654; GO:0006508; GO:0016805; GO:0032268; GO:0070062 0 0 0 PF07687;PF01546; D3ZQG6 CHOYP_TRI10.1.1 m.35701 sp TRIM2_RAT 25 292 189 10 15 293 12 286 8.88E-14 76.3 TRIM2_RAT reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) Trim2 Rattus norvegicus (Rat) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; P49395 CHOYP_RS3A.9.15 m.36330 sp RS3A_APLCA 83.744 203 33 0 338 540 1 203 8.88E-116 346 RS3A_APLCA reviewed 40S ribosomal protein S3a (Lysine-rich protein KRP-A) RPS3A KRP-A Aplysia californica (California sea hare) 265 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627 0 0 0 PF01015; P86854 CHOYP_NEMVEDRAFT_V1G238062.3.6 m.5146 sp PLCL_MYTGA 32.075 106 66 3 30 133 30 131 8.88E-15 71.2 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q04832 CHOYP_ODC1.1.1 m.12032 sp HEXP_LEIMA 39.303 201 88 5 4 173 16 213 8.88E-32 118 HEXP_LEIMA reviewed DNA-binding protein HEXBP (Hexamer-binding protein) HEXBP Leishmania major 271 0 GO:0003677; GO:0005634; GO:0008270 0 0 0 PF00098; Q2KI56 CHOYP_LOC100378691.2.2 m.40118 sp CSN7B_BOVIN 55.642 257 110 2 4 256 6 262 8.88E-96 285 CSN7B_BOVIN reviewed COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) COPS7B Bos taurus (Bovine) 264 cullin deneddylation [GO:0010388] GO:0005737; GO:0008180; GO:0010388 0 0 0 PF01399; Q5ZLD3 CHOYP_PHUM_PHUM000260.1.1 m.59520 sp KLH13_CHICK 30.162 557 369 12 18 567 43 586 8.88E-76 256 KLH13_CHICK reviewed Kelch-like protein 13 KLHL13 RCJMB04_6k12 Gallus gallus (Chicken) 629 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q6NYU2 CHOYP_LOC656497.1.1 m.65231 sp HELZ_DANRE 41.748 103 58 1 1 103 853 953 8.88E-20 90.1 HELZ_DANRE reviewed Probable helicase with zinc finger domain (EC 3.6.4.-) helz zgc:77407 Danio rerio (Zebrafish) (Brachydanio rerio) 1860 0 GO:0003677; GO:0003700; GO:0004386; GO:0005524; GO:0005634; GO:0046872 0 0 0 PF00642; Q7SXM7 CHOYP_PRP31.1.6 m.4168 sp PRP31_DANRE 72.43 214 58 1 2 215 91 303 8.88E-111 329 PRP31_DANRE reviewed U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Danio rerio (Zebrafish) (Brachydanio rerio) 508 "mRNA splicing, via spliceosome [GO:0000398]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000398; GO:0003723; GO:0005687; GO:0005690; GO:0046540; GO:0060041; GO:0071011; GO:0071339; GO:0097526 0 0 0 PF01798;PF09785; Q8MS27 CHOYP_RM35.1.1 m.18295 sp RM35_DROME 56.18 89 36 1 93 181 84 169 8.88E-28 105 RM35_DROME reviewed "39S ribosomal protein L35, mitochondrial (L35mt) (MRP-L35)" mRpL35 CG13410 Drosophila melanogaster (Fruit fly) 178 epithelium development [GO:0060429]; germarium-derived egg chamber formation [GO:0007293]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005762; GO:0006412; GO:0007293; GO:0060429 0 0 0 PF01632; Q9Z1J2 CHOYP_GSPATT00007491001.1.1 m.53430 sp NEK4_MOUSE 35.664 286 156 8 16 289 10 279 8.88E-49 181 NEK4_MOUSE reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) Nek4 Stk2 Mus musculus (Mouse) 792 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; A7S1L6 CHOYP_BRAFLDRAFT_118197.1.1 m.31498 sp FUCT1_NEMVE 62.5 336 126 0 8 343 3 338 8.89E-152 433 FUCT1_NEMVE reviewed GDP-fucose transporter 1 (Solute carrier family 35 member C1 homolog) slc35c1 fuct1 v1g205399 Nematostella vectensis (Starlet sea anemone) 339 carbohydrate transport [GO:0008643] GO:0000139; GO:0008643; GO:0016021 0 0 0 PF03151; D2GXS7 CHOYP_BRAFLDRAFT_241726.5.22 m.6507 sp TRIM2_AILME 23.438 256 181 8 19 262 492 744 8.89E-11 65.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O70277 CHOYP_BRAFLDRAFT_69765.11.23 m.46278 sp TRIM3_RAT 27.692 130 87 3 70 192 614 743 8.89E-09 57.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O95817 CHOYP_RF12A.1.1 m.38413 sp BAG3_HUMAN 50 42 21 0 24 65 21 62 8.89E-07 54.3 BAG3_HUMAN reviewed BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) BAG3 BIS Homo sapiens (Human) 575 brain development [GO:0007420]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; negative regulation of apoptotic process [GO:0043066]; negative regulation of striated muscle cell apoptotic process [GO:0010664]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; regulation of cellular response to heat [GO:1900034]; spinal cord development [GO:0021510] GO:0000774; GO:0005737; GO:0005829; GO:0005886; GO:0005913; GO:0006457; GO:0007420; GO:0008625; GO:0010664; GO:0021510; GO:0030018; GO:0043005; GO:0043066; GO:0050821; GO:0071260; GO:0097192; GO:0098641; GO:1900034 0 0 0 PF02179;PF00397; P05094 CHOYP_LOC100890433.1.1 m.30609 sp ACTN1_CHICK 31.008 129 83 3 3 130 34 157 8.89E-08 60.8 ACTN1_CHICK reviewed Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) ACTN1 Gallus gallus (Chicken) 893 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; sarcomere organization [GO:0045214]; skeletal muscle fiber development [GO:0048741] GO:0001725; GO:0001726; GO:0005509; GO:0005623; GO:0005915; GO:0005923; GO:0005925; GO:0016328; GO:0017166; GO:0030018; GO:0030027; GO:0030274; GO:0030486; GO:0031252; GO:0042383; GO:0042803; GO:0045214; GO:0048741; GO:0051017; GO:0051219; GO:0051393; GO:0051764; GO:0090636; GO:0090637; GO:0097433; GO:1990357 0 0 0 PF00307;PF08726;PF00435; P42577 CHOYP_LOC100212469.1.1 m.22191 sp FRIS_LYMST 65.882 170 57 1 1 169 3 172 8.89E-75 224 FRIS_LYMST reviewed Soma ferritin (EC 1.16.3.1) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 174 cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826] GO:0004322; GO:0005737; GO:0006826; GO:0006879; GO:0008199 0 0 0 PF00210; P55088 CHOYP_AQP4.3.3 m.44128 sp AQP4_MOUSE 47.191 267 129 4 17 280 34 291 8.89E-79 244 AQP4_MOUSE reviewed Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) Aqp4 Mus musculus (Mouse) 323 cellular response to interferon-gamma [GO:0071346]; cellular water homeostasis [GO:0009992]; ion transmembrane transport [GO:0034220]; renal water absorption [GO:0070295]; sensory perception of sound [GO:0007605]; water homeostasis [GO:0030104]; water transport [GO:0006833] GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006833; GO:0007605; GO:0009897; GO:0009992; GO:0015250; GO:0015254; GO:0016021; GO:0016323; GO:0030104; GO:0034220; GO:0070295; GO:0071346 0 0 cd00333; PF00230; Q05204 CHOYP_FUCO.1.2 m.58755 sp LAMP1_BOVIN 24.286 420 260 18 199 596 24 407 8.89E-07 55.1 LAMP1_BOVIN reviewed Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (CD107 antigen-like family member A) (Chromaffin granule-associated membrane glycoprotein IIA) (CD antigen CD107a) LAMP1 Bos taurus (Bovine) 409 establishment of protein localization to organelle [GO:0072594]; Golgi to lysosome transport [GO:0090160]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; positive regulation of natural killer cell degranulation [GO:0043323]; protein stabilization [GO:0050821]; regulation of organelle transport along microtubule [GO:1902513] GO:0005765; GO:0005771; GO:0005829; GO:0005901; GO:0008021; GO:0008626; GO:0009897; GO:0010008; GO:0016021; GO:0042383; GO:0042470; GO:0043323; GO:0044194; GO:0045121; GO:0048471; GO:0050821; GO:0061474; GO:0070062; GO:0072594; GO:0090160; GO:1902513 0 0 0 PF01299; Q08B72 CHOYP_MATN1.2.5 m.45369 sp MYPOP_XENLA 28.462 130 88 3 11 140 10 134 8.89E-08 53.1 MYPOP_XENLA reviewed "Myb-related transcription factor, partner of profilin (Myb-related protein p42POP)" mypop p42pop Xenopus laevis (African clawed frog) 341 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF13873; Q502M6 CHOYP_TVAG_020440.13.21 m.32822 sp ANR29_DANRE 41.406 128 75 0 3 130 66 193 8.89E-27 103 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5ZJW8 CHOYP_PHYPADRAFT_196684.1.1 m.43952 sp DTL_CHICK 42.574 101 57 1 25 124 46 146 8.89E-24 98.6 DTL_CHICK reviewed Denticleless protein homolog DTL CDT2 RCJMB04_15a2 Gallus gallus (Chicken) 720 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; G2 DNA damage checkpoint [GO:0031572]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0004842; GO:0005634; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005813; GO:0006260; GO:0006511; GO:0006513; GO:0006974; GO:0009411; GO:0019985; GO:0031464; GO:0031465; GO:0031572; GO:0051726 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q6RVV4 CHOYP_BRAFLDRAFT_287444.3.5 m.17688 sp TIC32_PEA 34.539 304 169 8 2 298 29 309 8.89E-45 161 TIC32_PEA reviewed "Short-chain dehydrogenase TIC 32, chloroplastic (EC 1.1.1.-) (Translocon at the inner envelope membrane of chloroplasts 32) (PsTIC32)" TIC32 HP32 IEP32 Pisum sativum (Garden pea) 316 protein transport [GO:0015031] GO:0009706; GO:0015031; GO:0016491 0 0 0 PF00106; Q8HXX6 CHOYP_GM2A.3.3 m.46227 sp SAP3_MACFA 28.723 188 120 5 1 178 5 188 8.89E-25 98.2 SAP3_MACFA reviewed Ganglioside GM2 activator (Cerebroside sulfate activator protein) (GM2-AP) (Sphingolipid activator protein 3) (SAP-3) GM2A QccE-17591 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 190 ganglioside catabolic process [GO:0006689] GO:0005764; GO:0006689; GO:0008047; GO:0016787 0 0 0 PF02221; Q8VC31 CHOYP_LOC684934.1.1 m.1807 sp CCDC9_MOUSE 44.737 114 57 2 114 225 186 295 8.89E-20 97.1 CCDC9_MOUSE reviewed Coiled-coil domain-containing protein 9 Ccdc9 Mus musculus (Mouse) 543 0 GO:0044822 0 0 0 PF15266; Q96RW7 CHOYP_DANA_GF12310.1.1 m.34846 sp HMCN1_HUMAN 26.923 442 254 25 21 423 847 1258 8.89E-15 82.4 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9H4F8 CHOYP_LOC100374767.1.3 m.5588 sp SMOC1_HUMAN 42.647 136 73 2 35 170 31 161 8.89E-30 125 SMOC1_HUMAN reviewed SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1) SMOC1 Homo sapiens (Human) 434 cell differentiation [GO:0030154]; eye development [GO:0001654]; limb development [GO:0060173]; regulation of osteoblast differentiation [GO:0045667]; signal transduction [GO:0007165] GO:0001654; GO:0005509; GO:0005604; GO:0007165; GO:0030154; GO:0045667; GO:0060173 0 0 0 PF07648;PF10591;PF00086; Q9SMX5 CHOYP_ANR44.2.5 m.56590 sp AGD4_ARATH 41.096 73 43 0 81 153 676 748 8.89E-08 54.3 AGD4_ARATH reviewed ADP-ribosylation factor GTPase-activating protein AGD4 (ARF GAP AGD4) (GCN4-complementing protein 1) (Protein ARF-GAP DOMAIN 4) (AtAGD4) AGD4 GCP1 At1g10870 T19D16.20 Arabidopsis thaliana (Mouse-ear cress) 775 0 GO:0005096; GO:0005737; GO:0046872 0 0 0 PF12796;PF01412;PF00169; Q9SMX5 CHOYP_PDIA3.1.1 m.60224 sp AGD4_ARATH 41.096 73 43 0 81 153 676 748 8.89E-08 54.3 AGD4_ARATH reviewed ADP-ribosylation factor GTPase-activating protein AGD4 (ARF GAP AGD4) (GCN4-complementing protein 1) (Protein ARF-GAP DOMAIN 4) (AtAGD4) AGD4 GCP1 At1g10870 T19D16.20 Arabidopsis thaliana (Mouse-ear cress) 775 0 GO:0005096; GO:0005737; GO:0046872 0 0 0 PF12796;PF01412;PF00169; A3KN33 CHOYP_ISCW_ISCW020670.1.1 m.22298 sp EGFLA_BOVIN 32.558 86 55 2 134 217 355 439 8.90E-08 55.5 EGFLA_BOVIN reviewed "Pikachurin (EGF-like, fibronectin type-III and laminin G-like domain-containing protein)" EGFLAM Bos taurus (Bovine) 1018 0 GO:0005509; GO:0005578; GO:0030054; GO:0045202 0 0 0 PF00008;PF00041;PF00054;PF02210; P0DMQ6 CHOYP_LOC100370478.2.2 m.16291 sp DHSO_CHICK 61.449 345 133 0 16 360 4 348 8.90E-161 457 DHSO_CHICK reviewed Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase) SORD Gallus gallus (Chicken) 355 fructose biosynthetic process [GO:0046370]; fructose metabolic process [GO:0006000]; L-xylitol catabolic process [GO:0051160]; NADH oxidation [GO:0006116]; NADH regeneration [GO:0006735]; sorbitol biosynthetic process [GO:0006061]; sorbitol catabolic process [GO:0006062]; sperm motility [GO:0030317] GO:0003939; GO:0006000; GO:0006061; GO:0006062; GO:0006116; GO:0006735; GO:0008270; GO:0030317; GO:0031514; GO:0031966; GO:0032991; GO:0046370; GO:0046526; GO:0051160; GO:0051287; GO:0070062 0 0 0 PF08240;PF00107; Q3ZBF8 CHOYP_LOC100742830.1.1 m.16811 sp CERS2_BOVIN 41.049 324 186 4 1 322 22 342 8.90E-88 272 CERS2_BOVIN reviewed Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) CERS2 LASS2 Bos taurus (Bovine) 380 ceramide biosynthetic process [GO:0046513] GO:0003677; GO:0005783; GO:0005789; GO:0016021; GO:0031965; GO:0046513; GO:0050291 0 0 0 PF00046;PF03798; Q501S4 CHOYP_LOC100370417.1.1 m.50635 sp MET12_DANRE 30.247 162 108 3 1 159 57 216 8.90E-17 78.2 MET12_DANRE reviewed "Methyltransferase-like protein 12, mitochondrial (EC 2.1.1.-)" mettl12 zgc:113305 Danio rerio (Zebrafish) (Brachydanio rerio) 254 0 GO:0005739; GO:0008168 0 0 0 PF13847; Q80VI1 CHOYP_contig_012307 m.14146 sp TRI56_MOUSE 25.778 225 151 10 198 412 486 704 8.90E-07 55.1 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q86FP7 CHOYP_RS23.8.9 m.54957 sp RS23_DERVA 87.603 121 14 1 8 127 1 121 8.90E-72 223 RS23_DERVA reviewed 40S ribosomal protein S23 RpS23 Dermacentor variabilis (American dog tick) 143 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935 0 0 cd03367; PF00164; Q8IFN0 CHOYP_NEMVEDRAFT_V1G240601.2.6 m.32404 sp YD115_PLAF7 33.696 92 59 1 204 295 777 866 8.90E-06 50.8 YD115_PLAF7 reviewed Uncharacterized protein PFD1115c PFD1115c Plasmodium falciparum (isolate 3D7) 1612 0 GO:0016021 0 0 0 0 Q8NBD8 CHOYP_T229B.2.2 m.50103 sp T229B_HUMAN 62.411 141 53 0 6 146 2 142 8.90E-61 188 T229B_HUMAN reviewed Transmembrane protein 229B TMEM229B C14orf83 Homo sapiens (Human) 167 0 GO:0016021 0 0 0 PF06541; Q90YS3 CHOYP_RS2.9.10 m.55252 sp RS2_ICTPU 84.774 243 37 0 29 271 32 274 8.90E-152 427 RS2_ICTPU reviewed 40S ribosomal protein S2 rps2 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 277 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0015935 0 0 0 PF00333;PF03719; Q9ULJ7 CHOYP_AASI_1435.15.35 m.35634 sp ANR50_HUMAN 32.344 337 205 8 37 369 785 1102 8.90E-38 152 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; D3ZAT9 CHOYP_LOC100377010.9.16 m.39036 sp FAXC_RAT 34.928 209 126 5 1 201 128 334 8.91E-39 140 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; O75382 CHOYP_BRAFLDRAFT_92727.17.17 m.64736 sp TRIM3_HUMAN 28.017 232 143 10 42 261 484 703 8.91E-12 68.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P32320 CHOYP_LOC100699134.1.1 m.47940 sp CDD_HUMAN 48.855 131 67 0 11 141 16 146 8.91E-42 138 CDD_HUMAN reviewed Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) CDA CDD Homo sapiens (Human) 146 cell surface receptor signaling pathway [GO:0007166]; cytidine deamination [GO:0009972]; cytosine metabolic process [GO:0019858]; negative regulation of cell growth [GO:0030308]; negative regulation of nucleotide metabolic process [GO:0045980]; protein homotetramerization [GO:0051289]; pyrimidine-containing compound salvage [GO:0008655]; pyrimidine nucleoside salvage [GO:0043097] GO:0001882; GO:0004126; GO:0005576; GO:0005829; GO:0007166; GO:0008270; GO:0008655; GO:0009972; GO:0019858; GO:0030308; GO:0042803; GO:0043097; GO:0045980; GO:0051289 0 0 0 PF00383; P40305 CHOYP_contig_028430 m.32369 sp IFI27_HUMAN 38.095 105 54 3 68 165 19 119 8.91E-08 51.6 IFI27_HUMAN reviewed "Interferon alpha-inducible protein 27, mitochondrial (p27) (Interferon alpha-induced 11.5 kDa protein) (Interferon-stimulated gene 12a protein) (ISG12(a))" IFI27 Homo sapiens (Human) 119 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of protein export from nucleus [GO:0046825]; type I interferon signaling pathway [GO:0060337] GO:0000122; GO:0001102; GO:0005521; GO:0005637; GO:0005739; GO:0005741; GO:0006919; GO:0016021; GO:0046825; GO:0060337; GO:0097190 0 0 0 PF06140; P91645 CHOYP_CAC1A.1.2 m.48380 sp CAC1A_DROME 66.138 378 109 3 2 376 798 1159 8.91E-169 518 CAC1A_DROME reviewed Voltage-dependent calcium channel type A subunit alpha-1 (Protein cacophony) (Protein nightblind A) (Protein no-on-transient B) (Dmca1A) cac nbA nonB CG43368 Drosophila melanogaster (Fruit fly) 1851 "adult locomotory behavior [GO:0008344]; autophagosome maturation [GO:0097352]; autophagy [GO:0006914]; calcium ion transport [GO:0006816]; chemical synaptic transmission [GO:0007268]; courtship behavior [GO:0007619]; detection of light stimulus involved in visual perception [GO:0050908]; epithelial fluid transport [GO:0042045]; exocytosis [GO:0006887]; male courtship behavior, veined wing generated song production [GO:0045433]; membrane depolarization during action potential [GO:0086010]; multicellular organism development [GO:0007275]; neuron cellular homeostasis [GO:0070050]; neurotransmitter secretion [GO:0007269]; phototransduction [GO:0007602]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; regulation of heart rate [GO:0002027]; regulation of membrane potential in photoreceptor cell [GO:0016057]; regulation of neurotransmitter secretion [GO:0046928]; visual behavior [GO:0007632]" GO:0002027; GO:0005245; GO:0005509; GO:0005891; GO:0006816; GO:0006887; GO:0006914; GO:0007268; GO:0007269; GO:0007275; GO:0007602; GO:0007619; GO:0007632; GO:0008331; GO:0008332; GO:0008344; GO:0010524; GO:0016057; GO:0016323; GO:0016324; GO:0042045; GO:0045433; GO:0045887; GO:0046928; GO:0048786; GO:0050908; GO:0070050; GO:0086010; GO:0097352 0 0 0 PF08763;PF16905;PF00520; Q28IH8 CHOYP_LOC577550.1.1 m.36506 sp CFA36_XENTR 26.281 449 208 13 23 468 1 329 8.91E-31 124 CFA36_XENTR reviewed Cilia- and flagella-associated protein 36 (Coiled-coil domain-containing protein 104) cfap36 ccdc104 TNeu040m17.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 339 0 GO:0005634; GO:0005737; GO:0042995 0 0 0 PF11527; Q7T3C6 CHOYP_CPSF5.1.2 m.59012 sp CPSF5_DANRE 81.9 221 37 2 22 241 10 228 8.91E-131 371 CPSF5_DANRE reviewed Cleavage and polyadenylation specificity factor subunit 5 cpsf5 Danio rerio (Zebrafish) (Brachydanio rerio) 228 mRNA polyadenylation [GO:0006378]; mRNA processing [GO:0006397] GO:0003729; GO:0005849; GO:0006378; GO:0006397; GO:0016787; GO:0017091; GO:0042382 0 0 0 PF13869; G5EBU4 CHOYP_PHUM_PHUM017930.1.1 m.33869 sp ZAG1_CAEEL 80 95 19 0 954 1048 474 568 8.92E-46 178 ZAG1_CAEEL reviewed Zinc finger E-box-binding homeobox protein zag-1 (Zinc finger involved in axon guidance 1) (ZAG-1) zag-1 F28F9.1 Caenorhabditis elegans 596 "axon guidance [GO:0007411]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of axon extension [GO:0045773]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0005634; GO:0006351; GO:0007411; GO:0043565; GO:0045773; GO:0046872 0 0 0 PF00046;PF13912; P30151 CHOYP_TSP1.1.1 m.43967 sp EF1B_XENLA 60.784 102 34 1 25 120 1 102 8.92E-33 117 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; Q16YG0 CHOYP_CDC42.5.11 m.25605 sp CDC42_AEDAE 43.085 188 102 2 12 196 3 188 8.92E-50 162 CDC42_AEDAE reviewed Cdc42 homolog Cdc42 AAEL008543 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 191 maintenance of protein location [GO:0045185]; multicellular organism development [GO:0007275]; positive regulation of protein kinase activity [GO:0045860]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0005886; GO:0005912; GO:0007264; GO:0007275; GO:0045185; GO:0045860 0 0 0 PF00071; Q66KE8 CHOYP_BRAFLDRAFT_75956.1.1 m.9109 sp CCD78_XENLA 42.407 540 302 5 404 940 11 544 8.92E-123 387 CCD78_XENLA reviewed Coiled-coil domain-containing protein 78 (xCCDC78) ccdc78 Xenopus laevis (African clawed frog) 559 cell projection organization [GO:0030030]; de novo centriole assembly [GO:0098535] GO:0005814; GO:0030030; GO:0098535; GO:0098536 0 0 0 PF14739; Q6UWX4 CHOYP_BRAFLDRAFT_119012.1.1 m.8771 sp HIPL2_HUMAN 36.65 412 230 10 27 411 194 601 8.92E-73 246 HIPL2_HUMAN reviewed HHIP-like protein 2 HHIPL2 HHIP3 KIAA1822L UNQ841/PRO1779 Homo sapiens (Human) 724 carbohydrate metabolic process [GO:0005975] GO:0005576; GO:0005975; GO:0016901; GO:0048038 0 0 0 PF03024;PF07995; Q8NEE6 CHOYP_LOC100372542.2.3 m.63335 sp FXL13_HUMAN 36.364 704 424 10 128 813 2 699 8.92E-152 464 FXL13_HUMAN reviewed F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13) FBXL13 FBL13 Homo sapiens (Human) 735 0 0 0 0 0 PF13516; Q9VVE5 CHOYP_RBP6.1.2 m.6061 sp MSIR6_DROME 55.718 341 91 7 19 315 23 347 8.92E-115 340 MSIR6_DROME reviewed RNA-binding protein Musashi homolog Rbp6 Rbp6 RRM6 CG32169 Drosophila melanogaster (Fruit fly) 369 stem cell development [GO:0048864] GO:0000166; GO:0003727; GO:0005737; GO:0005844; GO:0008266; GO:0048864 0 0 0 PF00076; Q9Y2M2 CHOYP_LOC763611.2.2 m.30214 sp SSUH2_HUMAN 37.879 330 186 4 55 380 39 353 8.92E-77 244 SSUH2_HUMAN reviewed Protein SSUH2 homolog (Protein ssu-2 homolog) SSUH2 C3orf32 FLS485 Homo sapiens (Human) 353 0 GO:0005737 0 0 0 0 O73791 CHOYP_LOC101160063.2.4 m.4445 sp TIE2_DANRE 42.045 88 45 4 198 282 217 301 8.93E-12 68.9 TIE2_DANRE reviewed Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2) tie2 tie-2 Danio rerio (Zebrafish) (Brachydanio rerio) 1116 angiogenesis [GO:0001525]; heart development [GO:0007507]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001525; GO:0004714; GO:0005524; GO:0005737; GO:0005856; GO:0005887; GO:0005925; GO:0007169; GO:0007507 0 0 0 PF00041;PF07679;PF10430;PF07714; O75179 CHOYP_LOC100641396.23.27 m.60248 sp ANR17_HUMAN 32.485 511 306 16 57 541 222 719 8.93E-53 197 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P25931 CHOYP_LOC100372307.1.1 m.8666 sp NPYR_DROME 39.818 329 186 5 10 332 79 401 8.93E-86 271 NPYR_DROME reviewed Neuropeptide Y receptor (NPY-R) (PR4 receptor) (RYamide receptor) RYa-R NepYr CG5811 Drosophila melanogaster (Fruit fly) 464 cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186] GO:0001653; GO:0004983; GO:0005886; GO:0007166; GO:0007186; GO:0008188; GO:0016021 0 0 0 PF00001; P36993 CHOYP_BRAFLDRAFT_275870.1.1 m.12895 sp PPM1B_MOUSE 60.95 379 144 3 1 377 1 377 8.93E-174 492 PPM1B_MOUSE reviewed Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) Ppm1b Pp2c2 Pppm1b Mus musculus (Mouse) 390 negative regulation of defense response to virus [GO:0050687]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; N-terminal protein myristoylation [GO:0006499]; peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470] GO:0000287; GO:0004722; GO:0005829; GO:0006470; GO:0006499; GO:0016020; GO:0030145; GO:0032688; GO:0035970; GO:0042347; GO:0043124; GO:0050687 0 0 0 PF00481;PF07830; P51538 CHOYP_CP3AO.1.1 m.63459 sp CP3A9_RAT 35.477 482 288 13 64 541 34 496 8.93E-95 301 CP3A9_RAT reviewed Cytochrome P450 3A9 (EC 1.14.14.1) (3AH15) (CYPIIIA9) (Cytochrome P450 olfactive 3) (Cytochrome P450-OLF3) Cyp3a9 Cyp3a13 Rattus norvegicus (Rat) 503 response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608] GO:0004497; GO:0005506; GO:0005789; GO:0007608; GO:0008395; GO:0020037; GO:0031090; GO:0050896; GO:0070330 0 0 0 PF00067; P78329 CHOYP_BRAFLDRAFT_61250.7.14 m.41419 sp CP4F2_HUMAN 39.872 469 261 9 44 499 60 520 8.93E-114 349 CP4F2_HUMAN reviewed Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.13.194) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.13.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.13.30) CYP4F2 Homo sapiens (Human) 520 arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; oxidation-reduction process [GO:0055114]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377] GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006690; GO:0006691; GO:0007596; GO:0008217; GO:0008392; GO:0016324; GO:0016709; GO:0017144; GO:0018685; GO:0019369; GO:0019373; GO:0020037; GO:0031090; GO:0032304; GO:0032305; GO:0036101; GO:0042360; GO:0042361; GO:0042376; GO:0042377; GO:0043231; GO:0050051; GO:0052869; GO:0052871; GO:0052872; GO:0055078; GO:0055114; GO:0097258; GO:0097259; GO:0097267 PATHWAY: Cofactor degradation; phylloquinone degradation. {ECO:0000269|PubMed:24138531}. 0 0 PF00067; Q62158 CHOYP_LOC100373444.8.79 m.3255 sp TRI27_MOUSE 23.457 162 102 4 3 143 96 256 8.93E-06 51.2 TRI27_MOUSE reviewed Zinc finger protein RFP (EC 6.3.2.-) (Ret finger protein) (Tripartite motif-containing protein 27) Trim27 Rfp Mus musculus (Mouse) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005829; GO:0006351; GO:0006469; GO:0008270; GO:0016605; GO:0016874; GO:0030904; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0045087; GO:0045814; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; Q6DC77 CHOYP_MPRGB.1.2 m.55806 sp MPRGB_DANRE 47.853 326 151 3 53 360 10 334 8.93E-100 302 MPRGB_DANRE reviewed Membrane progestin receptor gamma-B (mPR gamma-B) (Progestin and adipoQ receptor family member V-B) paqr5b zgc:101065 Danio rerio (Zebrafish) (Brachydanio rerio) 347 multicellular organism development [GO:0007275]; oogenesis [GO:0048477]; response to steroid hormone [GO:0048545] GO:0003707; GO:0005496; GO:0005886; GO:0007275; GO:0016021; GO:0048477; GO:0048545 0 0 0 PF03006; Q6ZPS2 CHOYP_CARNS1.3.6 m.15063 sp CRNS1_MOUSE 66.216 74 25 0 11 84 639 712 8.93E-29 111 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q7LGC8 CHOYP_CHST2.1.1 m.18197 sp CHST3_HUMAN 26.879 346 208 12 131 442 135 469 8.93E-24 107 CHST3_HUMAN reviewed Carbohydrate sulfotransferase 3 (EC 2.8.2.17) (Chondroitin 6-O-sulfotransferase 1) (C6ST-1) (Chondroitin 6-sulfotransferase) (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (GST-0) CHST3 Homo sapiens (Human) 479 carbohydrate metabolic process [GO:0005975]; chondroitin sulfate biosynthetic process [GO:0030206]; mitophagy in response to mitochondrial depolarization [GO:0098779]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cellular component movement [GO:0051272]; positive regulation of defense response to virus by host [GO:0002230]; sulfur compound metabolic process [GO:0006790]; xenophagy [GO:0098792] GO:0000139; GO:0001517; GO:0002230; GO:0005975; GO:0006790; GO:0008146; GO:0008459; GO:0014012; GO:0016021; GO:0030206; GO:0050698; GO:0051272; GO:0098779; GO:0098792 0 0 0 PF00685; Q96WV6 CHOYP_LOC590125.6.7 m.53736 sp YHU2_SCHPO 27.638 199 142 2 103 300 1375 1572 8.93E-10 63.9 YHU2_SCHPO reviewed Uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 SPBPJ4664.02 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 3971 0 GO:0005886; GO:0031225 0 0 0 PF06131; Q9CQS5 CHOYP_contig_021670 m.24892 sp RIOK2_MOUSE 33.333 117 71 2 23 139 393 502 8.93E-07 50.1 RIOK2_MOUSE reviewed Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2) Riok2 Mus musculus (Mouse) 547 0 GO:0004674; GO:0005524; GO:0046872 0 0 0 PF09202; Q9GZR5 CHOYP_MGC115163.1.1 m.11715 sp ELOV4_HUMAN 45.679 243 131 1 18 260 33 274 8.93E-75 233 ELOV4_HUMAN reviewed Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4) ELOVL4 Homo sapiens (Human) 314 "fatty acid biosynthetic process [GO:0006633]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]" GO:0005783; GO:0006633; GO:0006636; GO:0008020; GO:0009922; GO:0019367; GO:0030148; GO:0030176; GO:0034625; GO:0034626; GO:0035338; GO:0042761; GO:0102336; GO:0102337; GO:0102338 "PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:20937905}." 0 0 PF01151; Q9H8W5 CHOYP_LOC100374741.68.83 m.55364 sp TRI45_HUMAN 24.766 214 143 6 11 207 133 345 8.93E-08 58.2 TRI45_HUMAN reviewed Tripartite motif-containing protein 45 (RING finger protein 99) TRIM45 RNF99 Homo sapiens (Human) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q9VN14 CHOYP_LOC100902807.1.4 m.12152 sp CONT_DROME 30.047 1278 764 32 26 1230 139 1359 8.93E-172 550 CONT_DROME reviewed Contactin Cont CG1084 Drosophila melanogaster (Fruit fly) 1390 axon ensheathment [GO:0008366]; cell adhesion involved in heart morphogenesis [GO:0061343]; establishment of glial blood-brain barrier [GO:0060857]; establishment or maintenance of epithelial cell apical/basal polarity [GO:0045197]; nerve maturation [GO:0021682]; septate junction assembly [GO:0019991] GO:0005886; GO:0005918; GO:0008366; GO:0019991; GO:0021682; GO:0031225; GO:0045197; GO:0060857; GO:0061343 0 0 0 PF00041;PF00047;PF00059; P24014 CHOYP_BRAFLDRAFT_69264.2.6 m.24788 sp SLIT_DROME 37.056 197 111 3 34 229 543 727 8.94E-32 129 SLIT_DROME reviewed Protein slit (dSlit) [Cleaved into: Protein slit N-product; Protein slit C-product] sli CG43758 Drosophila melanogaster (Fruit fly) 1504 "axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; dendrite morphogenesis [GO:0048813]; digestive tract mesoderm development [GO:0007502]; embryonic heart tube development [GO:0035050]; epithelial cell migration, open tracheal system [GO:0007427]; glial cell migration [GO:0008347]; gonad development [GO:0008406]; induction of negative chemotaxis [GO:0050929]; lateral inhibition [GO:0046331]; mesodermal cell migration [GO:0008078]; mesoderm migration involved in gastrulation [GO:0007509]; neuron differentiation [GO:0030182]; neuron migration [GO:0001764]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell-cell adhesion [GO:0022409]; regulation of axonogenesis [GO:0050770]; regulation of epithelial cell migration [GO:0010632]; regulation of epithelial cell migration, open tracheal system [GO:2000274]; Roundabout signaling pathway [GO:0035385]; salivary gland boundary specification [GO:0007432]" GO:0001764; GO:0003151; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005886; GO:0007411; GO:0007427; GO:0007432; GO:0007502; GO:0007509; GO:0008078; GO:0008201; GO:0008347; GO:0008406; GO:0010632; GO:0016199; GO:0022409; GO:0030182; GO:0031012; GO:0035050; GO:0035385; GO:0046331; GO:0048495; GO:0048813; GO:0048846; GO:0050770; GO:0050929; GO:0071666; GO:2000274 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P29691 CHOYP_EEF2.1.2 m.44023 sp EF2_CAEEL 60.075 268 106 1 1 267 169 436 8.94E-107 331 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; Q16943 CHOYP_VP33.1.2 m.1058 sp VP33_APLCA 55.805 267 97 6 1 253 1 260 8.94E-96 284 VP33_APLCA reviewed Vesicle-associated membrane protein/synaptobrevin-binding protein (VAP-33) 0 Aplysia californica (California sea hare) 260 protein localization to endoplasmic reticulum [GO:0070972] GO:0005789; GO:0016021; GO:0030054; GO:0043005; GO:0045202; GO:0070972 0 0 0 PF00635; Q5BK46 CHOYP_LOC100552547.1.1 m.14759 sp RNH1_RAT 42.268 291 151 4 1 291 7 280 8.94E-70 221 RNH1_RAT reviewed Ribonuclease H1 (RNase H1) (EC 3.1.26.4) Rnaseh1 Rattus norvegicus (Rat) 285 "DNA replication, removal of RNA primer [GO:0043137]" GO:0000287; GO:0003676; GO:0004523; GO:0005737; GO:0043137 0 0 0 PF01693;PF00075; Q5VWJ9 CHOYP_LOC100376049.1.1 m.10489 sp SNX30_HUMAN 45.57 395 177 4 66 459 76 433 8.94E-121 364 SNX30_HUMAN reviewed Sorting nexin-30 SNX30 Homo sapiens (Human) 437 endocytosis [GO:0006897]; protein transport [GO:0015031]; vesicle organization [GO:0016050] GO:0005768; GO:0006897; GO:0015031; GO:0016050; GO:0019898; GO:0035091 0 0 0 PF03114;PF00787; Q7T163 CHOYP_LOC762964.2.10 m.20648 sp KDIS_DANRE 31.879 298 191 9 799 1087 4 298 8.94E-27 122 KDIS_DANRE reviewed Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein) kidins220 arms kidins220b si:dkeyp-7f8.3 si:dz119j18.2 zgc:63531 Danio rerio (Zebrafish) (Brachydanio rerio) 1672 nerve growth factor signaling pathway [GO:0038180]; nervous system development [GO:0007399]; regulation of protein kinase activity [GO:0045859] GO:0005770; GO:0007399; GO:0016021; GO:0019887; GO:0030165; GO:0038180; GO:0045859 0 0 0 PF00023;PF12796;PF07693; Q8TE56 CHOYP_ADAMTS16.1.1 m.28149 sp ATS17_HUMAN 25.725 552 301 23 78 557 83 597 8.94E-33 137 ATS17_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) ADAMTS17 Homo sapiens (Human) 1095 0 GO:0004222; GO:0005578; GO:0008270 0 0 0 PF05986;PF01562;PF01421;PF00090; Q9DB85 CHOYP_LOC661874.1.1 m.6975 sp RRP8_MOUSE 50.49 204 100 1 310 513 192 394 8.94E-66 223 RRP8_MOUSE reviewed Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1 homolog) Rrp8 Mus musculus (Mouse) 457 "cellular response to glucose starvation [GO:0042149]; chromatin silencing at rDNA [GO:0000183]; covalent chromatin modification [GO:0016569]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of cell cycle arrest [GO:0071158]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]" GO:0000183; GO:0005634; GO:0005677; GO:0005730; GO:0005737; GO:0005886; GO:0006351; GO:0006364; GO:0008757; GO:0016569; GO:0033553; GO:0035064; GO:0042149; GO:0044822; GO:0046015; GO:0071158; GO:0072332 0 0 0 PF05148; Q9Y6N9 CHOYP_WHRN.2.2 m.53763 sp USH1C_HUMAN 27.5 200 121 2 197 372 85 284 8.94E-13 74.7 USH1C_HUMAN reviewed Harmonin (Antigen NY-CO-38/NY-CO-37) (Autoimmune enteropathy-related antigen AIE-75) (Protein PDZ-73) (Renal carcinoma antigen NY-REN-3) (Usher syndrome type-1C protein) USH1C AIE75 Homo sapiens (Human) 552 brush border assembly [GO:1904970]; cell differentiation [GO:0030154]; cellular protein complex assembly [GO:0043623]; equilibrioception [GO:0050957]; G2/M transition of mitotic cell cycle [GO:0000086]; photoreceptor cell maintenance [GO:0045494]; protein localization to microvillus [GO:1904106]; regulation of microvillus length [GO:0032532]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605] GO:0000086; GO:0001750; GO:0001917; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005902; GO:0005903; GO:0007605; GO:0030154; GO:0030507; GO:0032420; GO:0032532; GO:0043623; GO:0045177; GO:0045202; GO:0045494; GO:0050953; GO:0050957; GO:1904106; GO:1904970 0 0 0 PF00595; A2BDB0 CHOYP_LOC101470738.1.2 m.2088 sp ACTG_XENLA 98.601 143 2 0 69 211 130 272 8.95E-99 294 ACTG_XENLA reviewed "Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]" actg1 Xenopus laevis (African clawed frog) 375 0 GO:0005524; GO:0005856; GO:0005886; GO:0005925; GO:0097433 0 0 0 PF00022; A6NNW6 CHOYP_BRAFLDRAFT_85491.1.1 m.5622 sp ENO4_HUMAN 33.01 206 120 1 1 206 398 585 8.95E-35 134 ENO4_HUMAN reviewed Enolase 4 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) ENO4 C10orf134 Homo sapiens (Human) 628 glycolytic process [GO:0006096] GO:0000015; GO:0000287; GO:0004634; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. {ECO:0000250|UniProtKB:Q8C042}. 0 0 PF00113;PF03952; F6QEU4 CHOYP_LOC100892087.1.2 m.650 sp LIN41_XENTR 21.186 236 144 8 7 213 141 363 8.95E-06 49.3 LIN41_XENTR reviewed E3 ubiquitin-protein ligase TRIM71 (EC 6.3.2.-) (Protein lin-41 homolog) (Tripartite motif-containing protein 71) trim71 lin41 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 814 embryonic body morphogenesis [GO:0010172]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; miRNA mediated inhibition of translation [GO:0035278]; miRNA metabolic process [GO:0010586]; neural tube development [GO:0021915]; protein autoubiquitination [GO:0051865]; regulation of gene silencing by miRNA [GO:0060964]; regulation of neural precursor cell proliferation [GO:2000177]; stem cell proliferation [GO:0072089] GO:0000082; GO:0000932; GO:0004842; GO:0008270; GO:0008543; GO:0010172; GO:0010586; GO:0016874; GO:0021915; GO:0035198; GO:0035278; GO:0051865; GO:0060964; GO:0072089; GO:2000177 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643; P57756 CHOYP_LOC755229.1.1 m.5006 sp FCN2_RAT 49.321 221 107 3 28 244 100 319 8.95E-69 217 FCN2_RAT reviewed Ficolin-2 (Collagen/fibrinogen domain-containing protein 2) (Ficolin-B) (Ficolin-beta) (L-ficolin) Fcn2 Fcnb Rattus norvegicus (Rat) 319 "complement activation, lectin pathway [GO:0001867]" GO:0001867; GO:0005576; GO:0005581; GO:0030246; GO:0033691; GO:0046872 0 0 0 PF01391;PF00147; Q3U034 CHOYP_METTL4.2.2 m.19009 sp METL4_MOUSE 29.882 425 205 9 39 450 84 428 8.95E-49 176 METL4_MOUSE reviewed Methyltransferase-like protein 4 (EC 2.1.1.-) Mettl4 Mus musculus (Mouse) 471 0 GO:0003676; GO:0005634; GO:0009007 0 0 0 PF05063; Q7YQK9 CHOYP_CD82.1.3 m.16182 sp TSN7_PONPY 31.878 229 146 5 11 238 11 230 8.95E-34 125 TSN7_PONPY reviewed Tetraspanin-7 (Tspan-7) (Transmembrane 4 superfamily member 2) (CD antigen CD231) TSPAN7 TM4SF2 Pongo pygmaeus (Bornean orangutan) 244 0 GO:0016021 0 0 0 PF00335; Q80XC3 CHOYP_PHUM_PHUM537100.1.1 m.62217 sp US6NL_MOUSE 49.061 479 207 7 24 478 6 471 8.95E-152 463 US6NL_MOUSE reviewed USP6 N-terminal-like protein Usp6nl Kiaa0019 Mus musculus (Mouse) 819 "activation of GTPase activity [GO:0090630]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; plasma membrane to endosome transport [GO:0048227]; regulation of Golgi organization [GO:1903358]; regulation of vesicle fusion [GO:0031338]; retrograde transport, plasma membrane to Golgi [GO:0035526]; virion assembly [GO:0019068]" GO:0005096; GO:0005794; GO:0005886; GO:0006886; GO:0007030; GO:0012505; GO:0016023; GO:0017137; GO:0019068; GO:0031338; GO:0031410; GO:0035526; GO:0048227; GO:0090630; GO:1903358 0 0 0 PF00566; Q96MU7 CHOYP_YTDC1.1.2 m.56406 sp YTDC1_HUMAN 46.154 429 195 12 194 607 260 667 8.95E-93 305 YTDC1_HUMAN reviewed YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) YTHDC1 KIAA1966 YT521 Homo sapiens (Human) 727 "mRNA splice site selection [GO:0006376]; regulation of mRNA splicing, via spliceosome [GO:0048024]" GO:0003723; GO:0005634; GO:0006376; GO:0016607; GO:0044822; GO:0048024; GO:1990247 0 0 0 PF04146; Q96MU7 CHOYP_YTDC1.2.2 m.57721 sp YTDC1_HUMAN 46.154 429 195 12 194 607 260 667 8.95E-93 305 YTDC1_HUMAN reviewed YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) YTHDC1 KIAA1966 YT521 Homo sapiens (Human) 727 "mRNA splice site selection [GO:0006376]; regulation of mRNA splicing, via spliceosome [GO:0048024]" GO:0003723; GO:0005634; GO:0006376; GO:0016607; GO:0044822; GO:0048024; GO:1990247 0 0 0 PF04146; Q9P215 CHOYP_LOC100560153.2.3 m.12798 sp POGK_HUMAN 37.121 132 79 3 219 347 193 323 8.95E-17 87.8 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; Q9TTA5 CHOYP_LOC576458.1.1 m.13195 sp SMAL1_BOVIN 62.044 137 48 3 1 135 358 492 8.95E-50 172 SMAL1_BOVIN reviewed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.4.-) (HepA-related protein) (Sucrose nonfermenting protein 2-like 1) SMARCAL1 HARP Bos taurus (Bovine) 940 cellular response to DNA damage stimulus [GO:0006974]; DNA metabolic process [GO:0006259]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; replication fork processing [GO:0031297] GO:0004386; GO:0005524; GO:0005634; GO:0005654; GO:0005662; GO:0006259; GO:0006357; GO:0006974; GO:0008094; GO:0031297; GO:0035861; GO:0036310 0 0 0 PF07443;PF00271;PF00176; Q9VCA2 CHOYP_LOC100369713.1.1 m.65779 sp ORCT_DROME 29.197 548 314 11 8 542 4 490 8.95E-62 216 ORCT_DROME reviewed Organic cation transporter protein Orct CG6331 Drosophila melanogaster (Fruit fly) 548 apoptotic process [GO:0006915]; ion transport [GO:0006811] GO:0005887; GO:0006811; GO:0006915; GO:0016021; GO:0022891 0 0 cd06174; PF00083; Q9VH14 CHOYP_LOC100702284.1.1 m.66842 sp TIMP_DROME 36.047 86 54 1 18 102 25 110 8.95E-12 62 TIMP_DROME reviewed Tissue inhibitor of metalloproteases Timp CG6281 Drosophila melanogaster (Fruit fly) 210 "basement membrane organization [GO:0071711]; cell adhesion [GO:0007155]; delamination [GO:0060232]; imaginal disc-derived wing expansion [GO:0048526]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; phototaxis [GO:0042331]; response to organic substance [GO:0010033]; tracheal outgrowth, open tracheal system [GO:0007426]; tracheal pit formation in open tracheal system [GO:0035202]; wing disc morphogenesis [GO:0007472]" GO:0002020; GO:0005578; GO:0005615; GO:0007155; GO:0007426; GO:0007472; GO:0008191; GO:0010033; GO:0030425; GO:0035202; GO:0042331; GO:0046872; GO:0048526; GO:0051045; GO:0060232; GO:0071711 0 0 0 PF00965; Q9Y2V2 CHOYP_CARHSP1.1.1 m.11310 sp CHSP1_HUMAN 63.063 111 41 0 21 131 30 140 8.95E-45 146 CHSP1_HUMAN reviewed Calcium-regulated heat-stable protein 1 (Calcium-regulated heat-stable protein of 24 kDa) (CRHSP-24) CARHSP1 Homo sapiens (Human) 147 "intracellular signal transduction [GO:0035556]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000177; GO:0000932; GO:0003677; GO:0003730; GO:0005829; GO:0006355; GO:0019902; GO:0035556; GO:0043186; GO:0043488; GO:0070062 0 0 cd04458; PF00313; O01761 CHOYP_BRAFLDRAFT_129004.4.15 m.32168 sp UNC89_CAEEL 24.819 415 272 17 187 586 4296 4685 8.96E-11 70.1 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; O70511 CHOYP_AASI_1435.21.35 m.46504 sp ANK3_RAT 25.193 647 391 24 302 913 123 711 8.96E-21 103 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P61354 CHOYP_LOC100373506.3.8 m.30956 sp RL27_RAT 82.353 136 24 0 21 156 1 136 8.96E-80 236 RL27_RAT reviewed 60S ribosomal protein L27 Rpl27 Rattus norvegicus (Rat) 136 response to aldosterone [GO:1904044]; translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0022625; GO:1904044 0 0 0 PF00467;PF01777; Q0VB26 CHOYP_BRAFLDRAFT_117083.1.3 m.14629 sp TEX26_MOUSE 26.768 198 138 4 116 308 49 244 8.96E-12 68.6 TEX26_MOUSE reviewed Testis-expressed sequence 26 protein Tex26 Mus musculus (Mouse) 296 0 0 0 0 0 0 Q1LXS2 CHOYP_PSMG2.1.1 m.66279 sp PSMG2_DANRE 45.42 262 128 4 12 270 11 260 8.96E-77 236 PSMG2_DANRE reviewed Proteasome assembly chaperone 2 (Tumor necrosis factor superfamily member 5-induced protein 1 homolog) psmg2 tnfsf5ip1 si:dkey-263o22.1 wu:fb51b11 zgc:73278 Danio rerio (Zebrafish) (Brachydanio rerio) 260 proteasome assembly [GO:0043248] GO:0000502; GO:0005634; GO:0005829; GO:0043248 0 0 0 PF09754; Q8NHQ8 CHOYP_LOC100116246.1.1 m.10912 sp RASF8_HUMAN 68.354 79 25 0 3 81 2 80 8.96E-30 125 RASF8_HUMAN reviewed Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) RASSF8 C12orf2 Homo sapiens (Human) 419 adherens junction maintenance [GO:0034334]; signal transduction [GO:0007165] GO:0007165; GO:0034334 0 0 0 PF00788; Q8VIK5 CHOYP_contig_017386 m.20399 sp PEAR1_MOUSE 33.14 344 193 14 100 440 473 782 8.96E-34 140 PEAR1_MOUSE reviewed Platelet endothelial aggregation receptor 1 (mPEAR1) (Jagged and Delta protein) (Protein Jedi) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12) Pear1 Jedi Megf12 Mus musculus (Mouse) 1034 negative regulation of Notch signaling pathway [GO:0045746]; recognition of apoptotic cell [GO:0043654] GO:0001891; GO:0016021; GO:0043654; GO:0045746 0 0 0 PF00053; Q20681 CHOYP_NEMVEDRAFT_V1G213290.1.2 m.36865 sp BAT38_CAEEL 35.417 96 60 2 30 124 227 321 8.97E-09 58.5 BAT38_CAEEL reviewed BTB and MATH domain-containing protein 38 bath-38 F52H3.3 Caenorhabditis elegans 387 0 0 0 0 0 PF00651;PF00917; Q2NL11 CHOYP_LOC100378269.1.2 m.12226 sp CH074_BOVIN 29.482 251 170 3 15 261 9 256 8.97E-25 104 CH074_BOVIN reviewed Uncharacterized protein C8orf74 homolog 0 Bos taurus (Bovine) 293 0 0 0 0 0 PF14769; Q3UQ28 CHOYP_TITIN.16.19 m.58231 sp PXDN_MOUSE 28.718 195 120 8 52 243 433 611 8.97E-11 66.2 PXDN_MOUSE reviewed Peroxidasin homolog (EC 1.11.1.7) Pxdn Kiaa0230 Mus musculus (Mouse) 1475 extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005201; GO:0005578; GO:0005615; GO:0005783; GO:0006979; GO:0020037; GO:0030198; GO:0031012; GO:0042744; GO:0046872; GO:0055114; GO:0070062 0 0 0 PF03098;PF07679;PF13855;PF00093; Q53G44 CHOYP_LOC100377780.8.11 m.53259 sp IF44L_HUMAN 29.655 435 284 12 56 485 18 435 8.97E-41 155 IF44L_HUMAN reviewed Interferon-induced protein 44-like IFI44L C1orf29 GS3686 Homo sapiens (Human) 452 defense response to virus [GO:0051607] GO:0005525; GO:0005654; GO:0005737; GO:0051607 0 0 0 PF01926; Q5VUM1 CHOYP_LOC101390307.1.1 m.44561 sp SDHF4_HUMAN 60.274 73 20 1 61 133 45 108 8.97E-22 86.3 SDHF4_HUMAN reviewed "Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)" SDHAF4 C6orf57 Homo sapiens (Human) 108 innate immune response [GO:0045087] GO:0005759; GO:0045087 0 0 0 PF07896; Q80TF4 CHOYP_KLH31.1.1 m.5070 sp KLH13_MOUSE 24.194 310 173 9 39 333 357 619 8.97E-20 94.4 KLH13_MOUSE reviewed Kelch-like protein 13 (BTB and kelch domain-containing protein 2) Klhl13 Bklhd2 Kiaa1309 Mus musculus (Mouse) 654 cytokinesis [GO:0000910]; mitotic nuclear division [GO:0007067]; protein ubiquitination [GO:0016567] GO:0000910; GO:0004842; GO:0007067; GO:0016567; GO:0030496; GO:0031463 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF07707;PF00651;PF01344; Q874R4 CHOYP_NEMVEDRAFT_V1G203594.2.2 m.64049 sp PFL3_SCHPO 41.971 274 111 17 60 311 505 752 8.97E-09 60.5 PFL3_SCHPO reviewed Putative cell agglutination protein pfl3 (Pombe flocculin 3) pfl3 SPBC947.04 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 973 cell adhesion [GO:0007155] GO:0005783; GO:0007155; GO:0010339 0 0 0 PF11763; Q8ISN9 CHOYP_RS25.11.11 m.49791 sp RS25_BRABE 77.011 87 20 0 31 117 28 114 8.97E-36 121 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8QZV1 CHOYP_BRAFLDRAFT_67316.1.1 m.5345 sp PDE9A_RAT 43.385 514 253 9 4 498 11 505 8.97E-144 427 PDE9A_RAT reviewed "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)" Pde9a Rattus norvegicus (Rat) 534 cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; cGMP metabolic process [GO:0046068]; positive regulation of cardiac muscle hypertrophy [GO:0010613] GO:0005783; GO:0005794; GO:0005829; GO:0010613; GO:0019934; GO:0032587; GO:0042383; GO:0043204; GO:0046068; GO:0046069; GO:0046872; GO:0047555; GO:0048471 "PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1." 0 0 PF00233; Q9Y6J8 CHOYP_NEMVEDRAFT_V1G86312.1.1 m.10844 sp STYL1_HUMAN 45.687 313 147 5 4 297 3 311 8.97E-86 262 STYL1_HUMAN reviewed Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Map kinase phosphatase-like protein MK-STYX) STYXL1 DUSP24 MKSTYX Homo sapiens (Human) 313 intracellular signal transduction [GO:0035556] GO:0005622; GO:0008138; GO:0035556 0 0 0 PF00782;PF00581; O70277 CHOYP_BRAFLDRAFT_87331.2.4 m.27360 sp TRIM3_RAT 28.244 131 86 4 65 188 614 743 8.98E-08 55.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P23284 CHOYP_LOC100313642.1.1 m.31841 sp PPIB_HUMAN 48.804 209 93 4 1 206 18 215 8.98E-55 177 PPIB_HUMAN reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB CYPB Homo sapiens (Human) 216 bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral process [GO:0044794]; positive regulation of multicellular organism growth [GO:0040018]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821] GO:0000413; GO:0003755; GO:0005634; GO:0005783; GO:0005788; GO:0005790; GO:0005925; GO:0016020; GO:0032403; GO:0032991; GO:0034663; GO:0040018; GO:0042277; GO:0042470; GO:0044794; GO:0044822; GO:0044829; GO:0048471; GO:0050821; GO:0051082; GO:0060348; GO:0061077; GO:0070062; GO:0070063 0 0 0 PF00160; P38942 CHOYP_LOC100372560.1.1 m.25500 sp CAT2_CLOK5 43.636 110 62 0 14 123 62 171 8.98E-26 103 CAT2_CLOK5 reviewed 4-hydroxybutyrate coenzyme A transferase (EC 2.8.3.-) cat2 CKL_3018 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) 429 acetyl-CoA metabolic process [GO:0006084] GO:0006084; GO:0016740 0 0 0 PF13336;PF02550; Q3T0D0 CHOYP_F26B1.2.1.1 m.31044 sp HNRPK_BOVIN 60.377 53 19 1 8 60 21 71 8.98E-10 57 HNRPK_BOVIN reviewed Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK Bos taurus (Bovine) 464 "mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045716]; positive regulation of receptor-mediated endocytosis [GO:0048260]; regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902165]; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [GO:0072369]; regulation of low-density lipoprotein particle clearance [GO:0010988]; RNA splicing [GO:0008380]" GO:0000790; GO:0000978; GO:0001077; GO:0002102; GO:0005654; GO:0005737; GO:0005925; GO:0006397; GO:0008380; GO:0010988; GO:0016020; GO:0042995; GO:0043066; GO:0044822; GO:0045716; GO:0048025; GO:0048260; GO:0070062; GO:0071013; GO:0072369; GO:1902165 0 0 0 PF00013;PF08067; Q502B3 CHOYP_B3GL2.2.2 m.14492 sp B3GL2_DANRE 27.635 351 227 7 43 373 47 390 8.98E-37 142 B3GL2_DANRE reviewed "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (Beta-1,3-GalNAc-T2) (EC 2.4.1.-) (Beta-1,3-N-acetylgalactosaminyltransferase II)" b3galnt2 zgc:112351 Danio rerio (Zebrafish) (Brachydanio rerio) 491 muscle fiber development [GO:0048747]; protein glycosylation [GO:0006486]; protein O-linked glycosylation [GO:0006493] GO:0000139; GO:0005783; GO:0006486; GO:0006493; GO:0008375; GO:0008376; GO:0008378; GO:0016021; GO:0048747 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01762; Q54BA2 CHOYP_LOC100374274.2.3 m.27036 sp Y3800_DICDI 31.818 198 101 5 36 230 18 184 8.98E-15 82.8 Y3800_DICDI reviewed "Ankyrin repeat, bromo and BTB domain-containing protein DDB_G0293800" DDB_G0293800 Dictyostelium discoideum (Slime mold) 806 0 0 0 0 0 PF12796;PF17035;PF00439;PF00651; Q61686 CHOYP_CBX1.1.4 m.5390 sp CBX5_MOUSE 57.714 175 54 3 88 249 20 187 8.98E-61 192 CBX5_MOUSE reviewed Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) Cbx5 Hp1a Mus musculus (Mouse) 191 "negative regulation of transcription, DNA-templated [GO:0045892]" GO:0000118; GO:0000776; GO:0000784; GO:0000792; GO:0003682; GO:0005634; GO:0005720; GO:0005721; GO:0005730; GO:0010369; GO:0016605; GO:0017053; GO:0030674; GO:0035064; GO:0035097; GO:0042803; GO:0042826; GO:0045892; GO:0070491 0 0 0 PF00385;PF01393; Q6RUV5 CHOYP_RAC2.1.1 m.25357 sp RAC1_RAT 81.699 153 28 0 1 153 1 153 8.98E-93 270 RAC1_RAT reviewed Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) Rac1 Rattus norvegicus (Rat) 192 "actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; actin filament polymerization [GO:0030041]; anatomical structure arrangement [GO:0048532]; auditory receptor cell morphogenesis [GO:0002093]; axon guidance [GO:0007411]; bone resorption [GO:0045453]; cell-cell junction organization [GO:0045216]; cell motility [GO:0048870]; cell proliferation [GO:0008283]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex GABAergic interneuron development [GO:0021894]; cerebral cortex radially oriented cell migration [GO:0021799]; chemotaxis [GO:0006935]; cochlea morphogenesis [GO:0090103]; dendrite morphogenesis [GO:0048813]; dopaminergic neuron differentiation [GO:0071542]; embryonic olfactory bulb interneuron precursor migration [GO:0021831]; engulfment of apoptotic cell [GO:0043652]; epithelial cell morphogenesis [GO:0003382]; G-protein coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; hyperosmotic response [GO:0006972]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; mast cell chemotaxis [GO:0002551]; negative regulation of interleukin-23 production [GO:0032707]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of DNA replication [GO:0045740]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein localization to plasma membrane [GO:0072659]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; regulation of cell size [GO:0008361]; regulation of fibroblast migration [GO:0010762]; regulation of neuron maturation [GO:0014041]; regulation of respiratory burst [GO:0060263]; ruffle assembly [GO:0097178]; semaphorin-plexin signaling pathway [GO:0071526]; substrate adhesion-dependent cell spreading [GO:0034446]; synaptic transmission, GABAergic [GO:0051932]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000139; GO:0001891; GO:0001934; GO:0002093; GO:0002551; GO:0003382; GO:0003924; GO:0005525; GO:0005634; GO:0005737; GO:0005802; GO:0005829; GO:0005884; GO:0005925; GO:0006935; GO:0006972; GO:0007015; GO:0007186; GO:0007411; GO:0008283; GO:0008361; GO:0010592; GO:0010762; GO:0014041; GO:0016020; GO:0016601; GO:0017137; GO:0019897; GO:0019901; GO:0021799; GO:0021831; GO:0021894; GO:0030027; GO:0030032; GO:0030036; GO:0030041; GO:0030334; GO:0030838; GO:0031410; GO:0031901; GO:0032587; GO:0032707; GO:0034446; GO:0036464; GO:0042470; GO:0042826; GO:0043552; GO:0043652; GO:0045216; GO:0045453; GO:0045740; GO:0048532; GO:0048813; GO:0048870; GO:0048873; GO:0051022; GO:0051496; GO:0051668; GO:0051894; GO:0051932; GO:0060071; GO:0060263; GO:0070062; GO:0071260; GO:0071526; GO:0071542; GO:0072659; GO:0090023; GO:0090103; GO:0097178; GO:1900026 0 0 0 PF00071; Q92752 CHOYP_FGL2.1.9 m.21917 sp TENR_HUMAN 44.749 219 113 5 73 289 1130 1342 8.98E-56 197 TENR_HUMAN reviewed Tenascin-R (TN-R) (Janusin) (Restrictin) TNR Homo sapiens (Human) 1358 "associative learning [GO:0008306]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005576; GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007155; GO:0007158; GO:0007411; GO:0008306; GO:0009986; GO:0022029; GO:0022408; GO:0030198; GO:0035641; GO:0045121; GO:0048692; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF07974;PF00147;PF00041; Q9Y5X5 CHOYP_TLR2.5.7 m.48858 sp NPFF2_HUMAN 22.819 298 194 9 15 299 182 456 8.98E-12 68.9 NPFF2_HUMAN reviewed Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) NPFFR2 GPR74 NPFF2 NPGPR Homo sapiens (Human) 522 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; detection of abiotic stimulus [GO:0009582]; G-protein coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase activity [GO:0045761]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of MAPK cascade [GO:0043408]; response to peptide [GO:1901652] GO:0004930; GO:0005886; GO:0005887; GO:0007186; GO:0007268; GO:0008188; GO:0009582; GO:0015629; GO:0032870; GO:0042277; GO:0043408; GO:0045761; GO:1901652; GO:2000479 0 0 0 PF00001; B3EWZ9 CHOYP_BRAFLDRAFT_74383.1.1 m.14279 sp HEPHL_ACRMI 27.192 1015 546 33 3 833 15 1020 8.99E-93 320 HEPHL_ACRMI reviewed Hephaestin-like protein (EC 1.-.-.-) 0 Acropora millepora (Staghorn coral) 1114 copper ion transport [GO:0006825] GO:0005507; GO:0006825; GO:0016021; GO:0016491 0 0 0 PF07731;PF07732; O57592 CHOYP_RL7A.6.6 m.40439 sp RL7A_TAKRU 77.143 70 15 1 19 88 16 84 8.99E-32 115 RL7A_TAKRU reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) rpl7a surf3 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0006412; GO:0022625 0 0 0 PF01248; P62264 CHOYP_LOC549476.1.1 m.42388 sp RS14_MOUSE 89.286 140 14 1 24 162 1 140 8.99E-89 259 RS14_MOUSE reviewed 40S ribosomal protein S14 Rps14 Mus musculus (Mouse) 151 "erythrocyte differentiation [GO:0030218]; maturation of SSU-rRNA [GO:0030490]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]" GO:0000028; GO:0000122; GO:0000462; GO:0003723; GO:0003735; GO:0005730; GO:0005737; GO:0005739; GO:0005925; GO:0006412; GO:0016020; GO:0022627; GO:0030218; GO:0030490; GO:0044822; GO:0045182; GO:0048027; GO:0070062; GO:0070181 0 0 0 PF00411; P72745 CHOYP_LOC587133.1.1 m.61281 sp Y1101_SYNY3 38.835 103 61 1 51 151 6 108 8.99E-15 68.9 Y1101_SYNY3 reviewed Universal stress protein Slr1101 (USP Slr1101) slr1101 Synechocystis sp. (strain PCC 6803 / Kazusa) 108 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P72745 CHOYP_NEMVEDRAFT_V1G236658.2.6 m.2257 sp Y1101_SYNY3 38.835 103 61 1 51 151 6 108 8.99E-15 68.9 Y1101_SYNY3 reviewed Universal stress protein Slr1101 (USP Slr1101) slr1101 Synechocystis sp. (strain PCC 6803 / Kazusa) 108 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P72745 CHOYP_NEMVEDRAFT_V1G244537.1.3 m.7917 sp Y1101_SYNY3 38.835 103 61 1 51 151 6 108 8.99E-15 68.9 Y1101_SYNY3 reviewed Universal stress protein Slr1101 (USP Slr1101) slr1101 Synechocystis sp. (strain PCC 6803 / Kazusa) 108 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q3B8D7 CHOYP_TC1DA.1.1 m.13118 sp TC1DA_XENLA 32.716 162 93 3 2 157 26 177 8.99E-23 91.7 TC1DA_XENLA reviewed Tctex1 domain-containing protein 1-A tctex1d1-a Xenopus laevis (African clawed frog) 177 0 0 0 0 0 PF03645; Q5EA68 CHOYP_S61A1.3.3 m.60323 sp S61A1_BOVIN 52.421 475 210 5 1321 1779 2 476 8.99E-151 475 S61A1_BOVIN reviewed Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) SEC61A1 Bos taurus (Bovine) 476 cell growth [GO:0016049]; endoplasmic reticulum organization [GO:0007029]; posttranslational protein targeting to membrane [GO:0006620]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614] GO:0006614; GO:0006620; GO:0007029; GO:0016049; GO:0030176; GO:0043022; GO:0045047 0 0 0 PF10559;PF00344; Q5ND28 CHOYP_ZGC_158328.2.2 m.52319 sp SREC_MOUSE 32.288 319 153 17 154 453 98 372 8.99E-27 119 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5RGB8 CHOYP_KLHL36.1.1 m.51668 sp KLH26_DANRE 25.783 543 344 14 4 530 103 602 8.99E-40 156 KLH26_DANRE reviewed Kelch-like protein 26 klhl26 si:ch211-255d18.7 Danio rerio (Zebrafish) (Brachydanio rerio) 605 protein ubiquitination [GO:0016567] GO:0016567; GO:0031463 0 0 0 PF07707;PF00651;PF01344; Q8IZN3 CHOYP_ZDHHC14.2.2 m.61670 sp ZDH14_HUMAN 70.091 331 96 2 7 336 8 336 8.99E-173 496 ZDH14_HUMAN reviewed Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.225) (NEW1 domain-containing protein) (NEW1CP) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) ZDHHC14 Homo sapiens (Human) 488 protein palmitoylation [GO:0018345] GO:0005783; GO:0008270; GO:0016021; GO:0016409; GO:0018345; GO:0019706 0 0 0 PF01529; Q8N2E2 CHOYP_NOTC2.5.5 m.66465 sp VWDE_HUMAN 32.881 295 156 13 138 426 1328 1586 8.99E-20 99 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8WTC1 CHOYP_DSIM_GD11682.1.1 m.30804 sp RT15_DROME 32.512 203 116 6 133 325 43 234 8.99E-15 77.4 RT15_DROME reviewed "28S ribosomal protein S15, mitochondrial (MRP-S15) (S15mt) (DmMRPS15) (Protein bonsai)" bonsai mRpS15 CG4207 Drosophila melanogaster (Fruit fly) 280 mitochondrial translation [GO:0032543]; regulation of growth [GO:0040008]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005763; GO:0006412; GO:0032543; GO:0040008 0 0 cd00353; PF00312; A4IF63 CHOYP_LOC100370588.10.19 m.32517 sp TRIM2_BOVIN 24.561 228 142 7 319 539 540 744 9.00E-09 62 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; A9ULZ2 CHOYP_LOC100122438.2.2 m.60108 sp BIR7B_XENLA 46.296 54 29 0 331 384 290 343 9.00E-09 60.1 BIR7B_XENLA reviewed Baculoviral IAP repeat-containing protein 7-B (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-B) (Embryonic/Egg IAP-B) (EIAP/XLX-B) birc7-b Xenopus laevis (African clawed frog) 345 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; O70277 CHOYP_BRAFLDRAFT_87270.1.2 m.33120 sp TRIM3_RAT 21.633 245 175 7 287 519 489 728 9.00E-10 65.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P19814 CHOYP_TGON1.1.1 m.51349 sp TGON3_RAT 36.364 110 53 5 262 370 260 353 9.00E-12 69.3 TGON3_RAT reviewed Trans-Golgi network integral membrane protein TGN38 Ttgn1 Rattus norvegicus (Rat) 357 Golgi to endosome transport [GO:0006895] GO:0005654; GO:0005768; GO:0005802; GO:0005829; GO:0006895; GO:0016021; GO:0030140 0 0 0 0 P57721 CHOYP_LOC658107.1.1 m.5318 sp PCBP3_HUMAN 65.909 176 55 2 18 189 46 220 9.00E-77 237 PCBP3_HUMAN reviewed Poly(rC)-binding protein 3 (Alpha-CP3) PCBP3 Homo sapiens (Human) 371 mRNA metabolic process [GO:0016071] GO:0003677; GO:0003723; GO:0005634; GO:0005829; GO:0016071; GO:0030529; GO:0044822; GO:0070062 0 0 0 PF00013; Q07DZ5 CHOYP_LOC579914.1.1 m.13347 sp CTTB2_ORNAN 31.373 714 449 9 628 1311 702 1404 9.00E-114 402 CTTB2_ORNAN reviewed Cortactin-binding protein 2 (CortBP2) CTTNBP2 CORTBP2 Ornithorhynchus anatinus (Duckbill platypus) 1635 0 GO:0005938; GO:0043197 0 0 0 PF12796;PF09727; Q11130 CHOYP_ISCW_ISCW024758.1.1 m.55469 sp FUT7_HUMAN 26.804 291 171 13 88 362 68 332 9.00E-26 109 FUT7_HUMAN reviewed "Alpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase) (Selectin ligand synthase)" FUT7 Homo sapiens (Human) 342 "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; leukocyte migration involved in immune response [GO:0002522]; L-fucose catabolic process [GO:0042355]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]" GO:0000139; GO:0002361; GO:0002522; GO:0005794; GO:0006486; GO:0006487; GO:0008417; GO:0016020; GO:0016021; GO:0032580; GO:0042355; GO:0046920 PATHWAY: Protein modification; protein glycosylation. 0 0 PF17039;PF00852; Q5E9E4 CHOYP_SSRB.1.2 m.5816 sp SSRB_BOVIN 60.221 181 68 2 27 207 1 177 9.00E-77 231 SSRB_BOVIN reviewed Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta) SSR2 Bos taurus (Bovine) 183 0 GO:0005789; GO:0016021 0 0 0 0 Q69ZK9 CHOYP_NLGN4.1.4 m.39 sp NLGN2_MOUSE 37.359 621 314 16 2 597 139 709 9.00E-119 379 NLGN2_MOUSE reviewed Neuroligin-2 Nlgn2 Kiaa1366 Mus musculus (Mouse) 836 "gephyrin clustering involved in postsynaptic density assembly [GO:0097116]; inhibitory synapse assembly [GO:1904862]; jump response [GO:0007630]; locomotory exploration behavior [GO:0035641]; modulation of synaptic transmission [GO:0050804]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of insulin secretion [GO:0032024]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of synapse assembly [GO:0051965]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of synaptic vesicle clustering [GO:2000809]; postsynaptic density protein 95 clustering [GO:0097119]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein localization to synapse [GO:0035418]; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000311]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; sensory perception of pain [GO:0019233]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]; terminal button organization [GO:0072553]; thigmotaxis [GO:0001966]" GO:0001966; GO:0002087; GO:0004872; GO:0005887; GO:0007158; GO:0007416; GO:0007630; GO:0009986; GO:0019233; GO:0030054; GO:0032024; GO:0032230; GO:0035176; GO:0035418; GO:0035641; GO:0042043; GO:0042734; GO:0045202; GO:0045211; GO:0050804; GO:0050808; GO:0050839; GO:0050885; GO:0051965; GO:0051968; GO:0052689; GO:0060076; GO:0060077; GO:0072553; GO:0097104; GO:0097105; GO:0097116; GO:0097119; GO:0097151; GO:1902474; GO:1904862; GO:2000311; GO:2000463; GO:2000809 0 0 0 PF00135; Q6P9H5 CHOYP_LOC569612.1.1 m.18528 sp GIMA6_HUMAN 28.74 254 151 10 34 273 37 274 9.00E-19 87.4 GIMA6_HUMAN reviewed GTPase IMAP family member 6 (Immunity-associated nucleotide 2 protein) (IAN-2) (hIAN2) (Immunity-associated nucleotide 6 protein) (IAN-6) (hIAN6) GIMAP6 IAN2 IAN6 Homo sapiens (Human) 292 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q6UPR8 CHOYP_NEMVEDRAFT_V1G238593.1.1 m.8407 sp ERMP1_RAT 53.465 303 139 2 75 377 98 398 9.00E-107 337 ERMP1_RAT reviewed Endoplasmic reticulum metallopeptidase 1 (EC 3.4.-.-) (Felix-ina) Ermp1 Fxna Rattus norvegicus (Rat) 898 ovarian follicle development [GO:0001541] GO:0001541; GO:0005783; GO:0005789; GO:0008237; GO:0016021; GO:0046872 0 0 0 PF04389; O57415 CHOYP_ZN836.1.1 m.50302 sp RREB1_CHICK 42.604 169 86 2 448 607 153 319 9.01E-35 145 RREB1_CHICK reviewed Ras-responsive element-binding protein 1 (RREB-1) RREB1 Gallus gallus (Chicken) 1615 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003700; GO:0005634; GO:0006355; GO:0006366; GO:0007165; GO:0007275; GO:0043565; GO:0044212; GO:0046872 0 0 0 PF13912; P18858 CHOYP_BRAFLDRAFT_69217.1.1 m.40000 sp DNLI1_HUMAN 40.196 102 53 3 24 121 222 319 9.01E-17 79 DNLI1_HUMAN reviewed DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1) LIG1 Homo sapiens (Human) 919 "anatomical structure morphogenesis [GO:0009653]; base-excision repair [GO:0006284]; cell division [GO:0051301]; DNA biosynthetic process [GO:0071897]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; mismatch repair [GO:0006298]; nucleotide-excision repair, DNA gap filling [GO:0006297]; Okazaki fragment processing involved in mitotic DNA replication [GO:1903461]; telomere maintenance via recombination [GO:0000722]; transcription-coupled nucleotide-excision repair [GO:0006283]" GO:0000722; GO:0003677; GO:0003909; GO:0003910; GO:0005524; GO:0005634; GO:0005654; GO:0005739; GO:0005794; GO:0006259; GO:0006281; GO:0006283; GO:0006284; GO:0006297; GO:0006298; GO:0009653; GO:0043231; GO:0046872; GO:0051301; GO:0071897; GO:1903461 0 0 0 PF04679;PF01068;PF04675; Q5TZ24 CHOYP_BRAFLDRAFT_125270.1.1 m.2429 sp MOXD1_DANRE 43.506 462 256 5 38 496 27 486 9.01E-119 383 MOXD1_DANRE reviewed DBH-like monooxygenase protein 1 homolog (EC 1.14.17.-) moxd1 si:ch211-193l17.1 si:dkey-266k12.5 si:dkeyp-119b4.5 Danio rerio (Zebrafish) (Brachydanio rerio) 614 0 GO:0005507; GO:0005789; GO:0016021; GO:0016715 0 0 0 PF03712;PF01082;PF03351; Q8CG80 CHOYP_SHD.1.1 m.20907 sp SHF_MOUSE 42.614 176 87 5 385 547 60 234 9.01E-31 123 SHF_MOUSE reviewed SH2 domain-containing adapter protein F Shf Mus musculus (Mouse) 238 apoptotic process [GO:0006915] GO:0006915 0 0 0 PF00017; Q8K4S1 CHOYP_LOC100870548.1.1 m.14348 sp PLCE1_MOUSE 41.5 600 309 12 11 582 928 1513 9.01E-125 410 PLCE1_MOUSE reviewed "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)" Plce1 Kiaa1516 Plce Mus musculus (Mouse) 2282 activation of MAPK activity [GO:0000187]; glomerulus development [GO:0032835]; lipid catabolic process [GO:0016042]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; Ras protein signal transduction [GO:0007265]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277]; regulation of protein kinase activity [GO:0045859]; regulation of Ras protein signal transduction [GO:0046578] GO:0000139; GO:0000187; GO:0004435; GO:0004629; GO:0004871; GO:0005085; GO:0005737; GO:0005829; GO:0005886; GO:0007200; GO:0007265; GO:0008277; GO:0016042; GO:0019899; GO:0032835; GO:0045859; GO:0046578 0 0 0 PF00168;PF00388;PF00387;PF00788;PF00617; Q8R4P9 CHOYP_LOC100702657.1.1 m.16177 sp MRP7_MOUSE 55.418 323 137 3 2 318 1159 1480 9.01E-104 335 MRP7_MOUSE reviewed Multidrug resistance-associated protein 7 (ATP-binding cassette sub-family C member 10) Abcc10 Mrp7 Mus musculus (Mouse) 1501 0 GO:0005524; GO:0005765; GO:0005886; GO:0016021; GO:0042626 0 0 0 PF00664;PF00005; Q96JM4 CHOYP_BRAFLDRAFT_124175.1.1 m.18995 sp LRIQ1_HUMAN 30.534 131 73 5 160 279 1031 1154 9.01E-06 50.8 LRIQ1_HUMAN reviewed Leucine-rich repeat and IQ domain-containing protein 1 LRRIQ1 KIAA1801 Homo sapiens (Human) 1722 0 0 0 0 0 PF00612; Q9CWD8 CHOYP_NUBPL.1.1 m.15123 sp NUBPL_MOUSE 69.888 269 81 0 41 309 48 316 9.01E-130 375 NUBPL_MOUSE reviewed Iron-sulfur protein NUBPL (Nucleotide-binding protein-like) Nubpl Mus musculus (Mouse) 319 mitochondrial respiratory chain complex I assembly [GO:0032981]; mitochondrion morphogenesis [GO:0070584] GO:0005524; GO:0005739; GO:0032981; GO:0046872; GO:0051539; GO:0070584 0 0 cd02037; 0 Q9DCN1 CHOYP_BRAFLDRAFT_115611.1.1 m.33392 sp NUD12_MOUSE 44.889 450 218 7 37 456 7 456 9.01E-130 386 NUD12_MOUSE reviewed Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12) Nudt12 Mus musculus (Mouse) 462 NAD catabolic process [GO:0019677]; NADP catabolic process [GO:0006742] GO:0000210; GO:0005634; GO:0005737; GO:0005777; GO:0006742; GO:0019677; GO:0035529; GO:0046872 0 0 0 PF12796;PF00293;PF09296;PF09297; Q9UGQ2 CHOYP_CBG07654.1.1 m.24662 sp FLOWR_HUMAN 41.216 148 84 1 17 161 24 171 9.01E-34 120 FLOWR_HUMAN reviewed Calcium channel flower homolog (Calcium channel flower domain-containing protein 1) CACFD1 C9orf7 PSEC0107 PSEC0248 UNQ3071/PRO9903 Homo sapiens (Human) 172 membrane depolarization [GO:0051899] GO:0005262; GO:0005886; GO:0016021; GO:0051899 0 0 0 PF10233; Q9UPQ0 CHOYP_LMO7.1.1 m.27803 sp LIMC1_HUMAN 32.11 436 230 19 31 436 23 422 9.01E-32 139 LIMC1_HUMAN reviewed LIM and calponin homology domains-containing protein 1 LIMCH1 KIAA1102 Homo sapiens (Human) 1083 actomyosin structure organization [GO:0031032] GO:0008270; GO:0031032 0 0 0 PF00307;PF15949;PF00412; B1H283 CHOYP_LOC100374808.1.1 m.29300 sp LEXM_RAT 38.021 384 227 8 4 383 6 382 9.02E-74 239 LEXM_RAT reviewed Lymphocyte expansion molecule Lexm Rattus norvegicus (Rat) 402 "CD8-positive, alpha-beta T cell proliferation [GO:0035740]; positive regulation of cell proliferation [GO:0008284]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of oxidative phosphorylation [GO:1903862]" GO:0005739; GO:0005761; GO:0008284; GO:0035740; GO:0043382; GO:1903862 0 0 0 0 B7ZMP1 CHOYP_LOC656459.1.1 m.34956 sp XPP3_MOUSE 35.797 433 257 9 43 469 71 488 9.02E-84 271 XPP3_MOUSE reviewed Probable Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) Xpnpep3 Mus musculus (Mouse) 506 glomerular filtration [GO:0003094]; protein processing [GO:0016485] GO:0003094; GO:0004177; GO:0005739; GO:0016485; GO:0030145; GO:0070062 0 0 0 PF05195;PF00557; P16537 CHOYP_LOC588285.1.1 m.60566 sp SPC3_STRPU 51.899 79 35 2 27 104 112 188 9.02E-20 87 SPC3_STRPU reviewed Protein SPEC3 SPEC3 Strongylocentrotus purpuratus (Purple sea urchin) 208 0 GO:0000139; GO:0005929; GO:0016021 0 0 0 PF15795; Q06852 CHOYP_NEMVEDRAFT_V1G208691.1.10 m.314 sp SLAP1_CLOTH 57.143 385 94 31 5 325 1590 1967 9.02E-19 90.9 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q12923 CHOYP_LOC100537667.1.1 m.15596 sp PTN13_HUMAN 36.458 288 170 6 3 284 640 920 9.02E-45 166 PTN13_HUMAN reviewed Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) PTPN13 PNP1 PTP1E PTPL1 Homo sapiens (Human) 2485 peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066] GO:0004725; GO:0005634; GO:0005737; GO:0005856; GO:0005886; GO:0006470; GO:0014066; GO:0030027; GO:0035335; GO:0036312; GO:0043005; GO:0044297; GO:0070062 0 0 0 PF09380;PF00373;PF09379;PF00595;PF00102; Q4R6C2 CHOYP_LOC100558121.1.1 m.6905 sp ZN383_MACFA 32.692 260 160 4 387 645 227 472 9.02E-33 136 ZN383_MACFA reviewed Zinc finger protein 383 ZNF383 QtsA-18358 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 475 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0046872 0 0 cd07765; PF01352;PF00096;PF13465; Q503Y7 CHOYP_ISCW_ISCW006091.2.2 m.61313 sp PIN4_DANRE 79.612 103 21 0 19 121 21 123 9.02E-59 180 PIN4_DANRE reviewed Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Rotamase Pin4) pin4 zgc:110008 Danio rerio (Zebrafish) (Brachydanio rerio) 128 0 GO:0003677; GO:0003755; GO:0005730; GO:0005737; GO:0005819 0 0 0 0 Q80T91 CHOYP_LOAG_07472.1.2 m.31765 sp MEG11_MOUSE 38.967 213 116 9 191 402 611 810 9.02E-28 121 MEG11_MOUSE reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) Megf11 Kiaa1781 Mus musculus (Mouse) 1091 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; Q8Q0U0 CHOYP_Y381.2.4 m.17878 sp Y045_METMA 32.143 280 165 8 13 289 69 326 9.02E-24 105 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q96GX9 CHOYP_MTNB.1.1 m.16051 sp MTNB_HUMAN 78.636 220 47 0 7 226 21 240 9.02E-128 363 MTNB_HUMAN reviewed Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP) APIP CGI-29 Homo sapiens (Human) 242 apoptotic process [GO:0006915]; L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; L-methionine biosynthetic process from S-adenosylmethionine [GO:0019284]; negative regulation of apoptotic process [GO:0043066]; protein homotetramerization [GO:0051289]; pyroptosis [GO:0070269]; regulation of ERK1 and ERK2 cascade [GO:0070372] GO:0005737; GO:0006915; GO:0008270; GO:0019284; GO:0019509; GO:0042802; GO:0043066; GO:0046570; GO:0051289; GO:0070269; GO:0070372 "PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:23285211, ECO:0000269|PubMed:24367089}." 0 0 PF00596; Q9BXJ4 CHOYP_CBLN2.1.2 m.63563 sp C1QT3_HUMAN 31.532 111 64 5 70 175 118 221 9.02E-09 57 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9DFQ7 CHOYP_RL24.7.9 m.50042 sp RL24_GILMI 61.006 159 59 2 1 158 1 157 9.02E-60 185 RL24_GILMI reviewed 60S ribosomal protein L24 rpl24 Gillichthys mirabilis (Long-jawed mudsucker) 157 0 GO:0005840 0 0 cd00472; PF01246; A2ASS6 CHOYP_LOC100367089.1.4 m.1412 sp TITIN_MOUSE 32.743 113 69 2 2 112 78 185 9.03E-10 58.2 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; P34501 CHOYP_YMS5.1.1 m.5494 sp YMS5_CAEEL 28.527 964 553 32 158 1019 311 1240 9.03E-95 335 YMS5_CAEEL reviewed Uncharacterized protein K03H1.5 K03H1.5 Caenorhabditis elegans 1385 cell-matrix adhesion [GO:0007160] GO:0007160 0 0 0 PF03782;PF06119;PF00084;PF00094; P58165 CHOYP_ISCW_ISCW010968.1.1 m.1994 sp AT2B2_OREMO 56.818 44 16 1 66 109 344 384 9.03E-07 49.3 AT2B2_OREMO reviewed Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 3.6.3.8) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) (Fragment) atp2b2 pmca Oreochromis mossambicus (Mozambique tilapia) (Tilapia mossambica) 1112 0 GO:0005388; GO:0005524; GO:0005886; GO:0016021; GO:0046872 0 0 0 PF00689;PF00690;PF00122;PF08282; P98160 CHOYP_TRIADDRAFT_62089.2.2 m.42458 sp PGBM_HUMAN 24.691 405 268 14 131 518 3017 3401 9.03E-18 92.8 PGBM_HUMAN reviewed Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] HSPG2 Homo sapiens (Human) 4391 angiogenesis [GO:0001525]; cellular protein metabolic process [GO:0044267]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; glycosaminoglycan metabolic process [GO:0030203]; lipoprotein metabolic process [GO:0042157]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0001525; GO:0005509; GO:0005576; GO:0005604; GO:0005615; GO:0005796; GO:0005886; GO:0005925; GO:0006024; GO:0006027; GO:0008022; GO:0022617; GO:0030198; GO:0030203; GO:0031012; GO:0042157; GO:0043202; GO:0044267; GO:0070062 0 0 0 PF00008;PF07679;PF13895;PF00052;PF00053;PF00054;PF00057; Q28DE6 CHOYP_LOC578100.3.3 m.56018 sp RSBNL_XENTR 67.532 231 72 1 1 231 416 643 9.03E-112 348 RSBNL_XENTR reviewed Round spermatid basic protein 1-like rsbn1l TEgg039d07.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 782 0 GO:0005634 0 0 0 0 Q2VLG6 CHOYP_BRAFLDRAFT_68915.7.7 m.58012 sp C163A_CANLF 41.606 274 155 4 1 272 116 386 9.03E-64 219 C163A_CANLF reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis lupus familiaris (Dog) (Canis familiaris) 1133 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q4ZJM9 CHOYP_C1QL4.9.10 m.64323 sp C1QL4_MOUSE 30.882 136 81 5 161 293 110 235 9.03E-08 55.5 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q5B8L2 CHOYP_BRAFLDRAFT_67480.1.1 m.14995 sp MUS81_EMENI 24.085 328 177 11 313 578 192 509 9.03E-09 64.3 MUS81_EMENI reviewed Crossover junction endonuclease mus81 (EC 3.1.22.-) mus81 AN3118 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) 677 "DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; intra-S DNA damage checkpoint [GO:0031573]; meiotic DNA repair synthesis [GO:0000711]; mitotic DNA replication checkpoint [GO:0033314]; resolution of meiotic recombination intermediates [GO:0000712]" GO:0000711; GO:0000712; GO:0000724; GO:0000737; GO:0003677; GO:0005634; GO:0005739; GO:0008821; GO:0031573; GO:0033314; GO:0046872; GO:0048476 0 0 0 PF02732; Q86VQ0 CHOYP_LOC583919.1.1 m.22145 sp LCA5_HUMAN 39.111 225 134 1 60 281 77 301 9.03E-36 147 LCA5_HUMAN reviewed Lebercilin (Leber congenital amaurosis 5 protein) LCA5 C6orf152 Homo sapiens (Human) 697 protein transport [GO:0015031] GO:0005737; GO:0005815; GO:0005929; GO:0015031; GO:0032403 0 0 0 PF15619; Q8C6K9 CHOYP_CO6A6.3.3 m.51505 sp CO6A6_MOUSE 25.321 624 394 19 28 639 612 1175 9.03E-44 172 CO6A6_MOUSE reviewed Collagen alpha-6(VI) chain Col6a6 Mus musculus (Mouse) 2265 cell adhesion [GO:0007155] GO:0005576; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00092; Q91XA9 CHOYP_CHIA.3.3 m.9445 sp CHIA_MOUSE 48.285 379 187 2 30 408 22 391 9.03E-126 403 CHIA_MOUSE reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) (YNL) Chia Chia1 Mus musculus (Mouse) 473 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532] GO:0000272; GO:0002376; GO:0002532; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0006032; GO:0006915; GO:0008061; GO:0019900; GO:0090197 0 0 0 PF01607;PF00704; Q923E4 CHOYP_SIRT1.1.1 m.9844 sp SIR1_MOUSE 50.864 521 208 9 106 607 161 652 9.03E-168 503 SIR1_MOUSE reviewed NAD-dependent protein deacetylase sirtuin-1 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] Sirt1 Sir2l1 Mus musculus (Mouse) 737 "angiogenesis [GO:0001525]; behavioral response to starvation [GO:0042595]; cellular glucose homeostasis [GO:0001678]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to starvation [GO:0009267]; cellular response to tumor necrosis factor [GO:0071356]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; chromatin organization [GO:0006325]; chromatin silencing at rDNA [GO:0000183]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA synthesis involved in DNA repair [GO:0000731]; establishment of chromatin silencing [GO:0006343]; fatty acid homeostasis [GO:0055089]; histone deacetylation [GO:0016575]; histone H3 deacetylation [GO:0070932]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; leptin-mediated signaling pathway [GO:0033210]; macrophage cytokine production [GO:0010934]; macrophage differentiation [GO:0030225]; maintenance of chromatin silencing [GO:0006344]; muscle organ development [GO:0007517]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of cell growth [GO:0030308]; negative regulation of cellular response to testosterone stimulus [GO:2000655]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of helicase activity [GO:0051097]; negative regulation of histone H3-K14 acetylation [GO:0071441]; negative regulation of histone H4-K16 acetylation [GO:2000619]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of neuron death [GO:1901215]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of peptidyl-lysine acetylation [GO:2000757]; negative regulation of phosphorylation [GO:0042326]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of protein acetylation [GO:1901984]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; ovulation from ovarian follicle [GO:0001542]; peptidyl-lysine acetylation [GO:0018394]; peptidyl-lysine deacetylation [GO:0034983]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cellular senescence [GO:2000774]; positive regulation of cholesterol efflux [GO:0010875]; positive regulation of chromatin silencing [GO:0031937]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA repair [GO:0045739]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of histone H3-K9 methylation [GO:0051574]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of macroautophagy [GO:0016239]; positive regulation of macrophage apoptotic process [GO:2000111]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deacetylation [GO:0006476]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; pyrimidine dimer repair by nucleotide-excision repair [GO:0000720]; regulation of bile acid biosynthetic process [GO:0070857]; regulation of brown fat cell differentiation [GO:0090335]; regulation of cell proliferation [GO:0042127]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of glucose metabolic process [GO:0010906]; regulation of lipid storage [GO:0010883]; regulation of mitotic cell cycle [GO:0007346]; regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035358]; regulation of protein import into nucleus, translocation [GO:0033158]; regulation of protein serine/threonine kinase activity [GO:0071900]; regulation of smooth muscle cell apoptotic process [GO:0034391]; response to hydrogen peroxide [GO:0042542]; response to insulin [GO:0032868]; response to leptin [GO:0044321]; response to oxidative stress [GO:0006979]; rRNA processing [GO:0006364]; single strand break repair [GO:0000012]; spermatogenesis [GO:0007283]; stress-induced premature senescence [GO:0090400]; transcription, DNA-templated [GO:0006351]; triglyceride mobilization [GO:0006642]; UV-damage excision repair [GO:0070914]; white fat cell differentiation [GO:0050872]" GO:0000012; GO:0000122; GO:0000183; GO:0000720; GO:0000731; GO:0000785; GO:0000790; GO:0001046; GO:0001525; GO:0001542; GO:0001678; GO:0001934; GO:0001938; GO:0002039; GO:0002821; GO:0003714; GO:0004407; GO:0005634; GO:0005635; GO:0005637; GO:0005654; GO:0005677; GO:0005719; GO:0005720; GO:0005730; GO:0005737; GO:0005739; GO:0006325; GO:0006343; GO:0006344; GO:0006351; GO:0006364; GO:0006476; GO:0006642; GO:0006974; GO:0006979; GO:0007283; GO:0007346; GO:0007517; GO:0007623; GO:0008022; GO:0008134; GO:0008284; GO:0008630; GO:0009267; GO:0010629; GO:0010875; GO:0010883; GO:0010906; GO:0010934; GO:0014068; GO:0016239; GO:0016567; GO:0016575; GO:0016605; GO:0017136; GO:0018394; GO:0019213; GO:0019899; GO:0019904; GO:0030225; GO:0030308; GO:0030512; GO:0031393; GO:0031648; GO:0031937; GO:0032007; GO:0032071; GO:0032088; GO:0032868; GO:0032922; GO:0033158; GO:0033210; GO:0033553; GO:0033558; GO:0034391; GO:0034979; GO:0034983; GO:0035098; GO:0035257; GO:0035356; GO:0035358; GO:0042127; GO:0042326; GO:0042393; GO:0042542; GO:0042595; GO:0042632; GO:0042771; GO:0042802; GO:0043065; GO:0043066; GO:0043124; GO:0043161; GO:0043280; GO:0043398; GO:0043425; GO:0043433; GO:0043518; GO:0044321; GO:0045348; GO:0045599; GO:0045739; GO:0045766; GO:0045892; GO:0045944; GO:0046628; GO:0046872; GO:0046969; GO:0050872; GO:0051019; GO:0051097; GO:0051574; GO:0051898; GO:0055089; GO:0060766; GO:0070301; GO:0070403; GO:0070857; GO:0070914; GO:0070932; GO:0071356; GO:0071441; GO:0071456; GO:0071479; GO:0071900; GO:0090335; GO:0090400; GO:1901215; GO:1901984; GO:1902166; GO:1902176; GO:1902237; GO:1904179; GO:1990254; GO:2000111; GO:2000480; GO:2000481; GO:2000619; GO:2000655; GO:2000757; GO:2000773; GO:2000774 0 0 0 PF02146; Q95230 CHOYP_LOC100373522.2.5 m.19698 sp SP17_PAPHA 43.396 159 73 4 16 164 1 152 9.03E-31 120 SP17_PAPHA reviewed Sperm surface protein Sp17 (Sperm autoantigenic protein 17) SPA17 SP17 Papio hamadryas (Hamadryas baboon) 163 binding of sperm to zona pellucida [GO:0007339] GO:0007339; GO:0016020 0 0 0 PF00612;PF02197; Q99PT3 CHOYP_BRAFLDRAFT_200162.4.4 m.59317 sp IN80B_MOUSE 39.326 178 82 5 72 223 84 261 9.03E-17 81.6 IN80B_MOUSE reviewed INO80 complex subunit B (High mobility group AT-hook 1-like 4) (PAP-1-associated protein 1) (PAPA-1) (Zinc finger HIT domain-containing protein 4) Ino80b Hmga1l4 Papa1 Znhit4 Mus musculus (Mouse) 375 "chromatin remodeling [GO:0006338]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005730; GO:0005737; GO:0005886; GO:0006281; GO:0006310; GO:0006338; GO:0006351; GO:0006355; GO:0031011; GO:0046872 0 0 0 PF04795;PF04438; A6BM72 CHOYP_MEG10.67.91 m.52967 sp MEG11_HUMAN 39.058 361 191 16 169 522 213 551 9.04E-49 186 MEG11_HUMAN reviewed Multiple epidermal growth factor-like domains protein 11 (Multiple EGF-like domains protein 11) MEGF11 KIAA1781 UNQ1949/PRO4432 Homo sapiens (Human) 1044 homotypic cell-cell adhesion [GO:0034109]; retina layer formation [GO:0010842] GO:0010842; GO:0016021; GO:0016323; GO:0034109 0 0 0 PF12661;PF00053; O65155 CHOYP_PITG_07058.1.1 m.51290 sp KELP_ARATH 37.179 78 48 1 225 301 86 163 9.04E-07 51.2 KELP_ARATH reviewed RNA polymerase II transcriptional coactivator KELP KELP At4g10920 F25I24.130 F8M12.6 Arabidopsis thaliana (Mouse-ear cress) 165 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003713; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08766;PF02229; P08548 CHOYP_LOC100490320.1.2 m.35571 sp LIN1_NYCCO 32.239 335 225 2 1 333 479 813 9.04E-45 167 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; Q5FVR5 CHOYP_LOC101029963.1.1 m.16661 sp ACNT2_RAT 32.367 207 134 3 23 223 205 411 9.04E-30 118 ACNT2_RAT reviewed Acyl-coenzyme A amino acid N-acyltransferase 2 (EC 2.3.1.-) Acnat2 Rattus norvegicus (Rat) 418 acyl-CoA metabolic process [GO:0006637]; fatty acid metabolic process [GO:0006631] GO:0005777; GO:0006631; GO:0006637; GO:0016410; GO:0016790 0 0 0 PF08840;PF04775; Q5RC69 CHOYP_NEMVEDRAFT_V1G233184.1.1 m.18285 sp DCTD_PONAB 67.879 165 53 0 24 188 7 171 9.04E-85 251 DCTD_PONAB reviewed Deoxycytidylate deaminase (EC 3.5.4.12) (dCMP deaminase) DCTD Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 178 nucleotide biosynthetic process [GO:0009165]; pyrimidine nucleotide metabolic process [GO:0006220] GO:0004132; GO:0006220; GO:0008270; GO:0009165; GO:0070062 0 0 cd01286; PF00383; Q5ZIQ3 CHOYP_Y023.1.1 m.28714 sp HNRPK_CHICK 56.621 219 90 3 7 225 18 231 9.04E-73 236 HNRPK_CHICK reviewed Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK RCJMB04_24e23 Gallus gallus (Chicken) 427 "mRNA processing [GO:0006397]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005654; GO:0005681; GO:0005737; GO:0006351; GO:0006357; GO:0006397; GO:0008380 0 0 0 PF00013;PF08067; Q6MG82 CHOYP_LOC100697066.1.1 m.31484 sp PRRT1_RAT 40.244 82 48 1 97 178 212 292 9.04E-12 65.5 PRRT1_RAT reviewed Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) Prrt1 Ng5 Rattus norvegicus (Rat) 306 response to biotic stimulus [GO:0009607] GO:0005886; GO:0009607; GO:0016021; GO:0030054; GO:0045202 0 0 0 PF04505; Q6PDJ1 CHOYP_CAHD1.1.6 m.20964 sp CAHD1_MOUSE 26.384 777 511 23 2 738 378 1133 9.04E-62 229 CAHD1_MOUSE reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) Cachd1 Kiaa1573 Vwcd1 Mus musculus (Mouse) 1288 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q96M86 CHOYP_LOC100376274.5.7 m.38330 sp DNHD1_HUMAN 30.374 214 129 7 54 265 2366 2561 9.04E-11 65.9 DNHD1_HUMAN reviewed Dynein heavy chain domain-containing protein 1 (Dynein heavy chain domain 1-like protein) (Protein CCDC35) DNHD1 C11orf47 CCDC35 DHCD1 DNHD1L UNQ5781/PRO12970 Homo sapiens (Human) 4753 microtubule-based movement [GO:0007018] GO:0003777; GO:0007018; GO:0030286; GO:0070062 0 0 0 PF08393;PF03028;PF12777; Q9IBD8 CHOYP_LOC100208023.6.8 m.46001 sp PTPRC_CYPCA 43.379 219 119 5 534 748 582 799 9.04E-52 198 PTPRC_CYPCA reviewed Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (CD antigen CD45) ptprc Cyprinus carpio (Common carp) 1216 T cell receptor signaling pathway [GO:0050852] GO:0004725; GO:0016021; GO:0050852 0 0 0 PF00102; Q9NZN5 CHOYP_LOC100071503.1.1 m.1843 sp ARHGC_HUMAN 67.778 90 29 0 137 226 67 156 9.04E-33 133 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q9W534 CHOYP_contig_023660 m.26915 sp MOODY_DROME 21.951 287 186 10 12 293 122 375 9.04E-08 58.5 MOODY_DROME reviewed G-protein coupled receptor moody moody CG4322 Drosophila melanogaster (Fruit fly) 670 axon ensheathment [GO:0008366]; behavioral response to cocaine [GO:0048148]; behavioral response to ethanol [GO:0048149]; behavioral response to nicotine [GO:0035095]; cell surface receptor signaling pathway [GO:0007166]; cortical actin cytoskeleton organization [GO:0030866]; establishment of glial blood-brain barrier [GO:0060857]; G-protein coupled receptor signaling pathway [GO:0007186]; septate junction assembly [GO:0019991]; ventral cord development [GO:0007419] GO:0004930; GO:0005886; GO:0005887; GO:0005919; GO:0007166; GO:0007186; GO:0007419; GO:0008366; GO:0016021; GO:0019991; GO:0030866; GO:0035095; GO:0048148; GO:0048149; GO:0060857 0 0 0 PF00001; B9A8D7 CHOYP_SPI2.29.37 m.30551 sp SPI2_CRAVI 36.471 85 51 2 21 104 1 83 9.05E-08 48.9 SPI2_CRAVI reviewed Serine protease inhibitor Cvsi-2 CVSI2 Crassostrea virginica (Eastern oyster) 85 0 GO:0004867; GO:0005576 0 0 0 0 P13418 CHOYP_IAPVOB_GP2.1.1 m.25701 sp POLS_CRPVC 33.755 237 147 6 105 332 1 236 9.05E-31 129 POLS_CRPVC reviewed Structural polyprotein [Cleaved into: Capsid protein 1 (CP1); Capsid protein 4 (CP4); Capsid protein 2 (CP2); Capsid protein 3 (CP3)] 0 Cricket paralysis virus (isolate Teleogryllus commodus/Australia/CrPVVIC/1968) (CrPV) 895 0 GO:0005198; GO:0019028; GO:0030430 0 0 cd00205; PF08762;PF11492;PF00073; P55042 CHOYP_LOC100119620.2.2 m.36213 sp RAD_HUMAN 34.343 198 120 3 167 358 92 285 9.05E-25 105 RAD_HUMAN reviewed GTP-binding protein RAD (RAD1) (Ras associated with diabetes) RRAD RAD Homo sapiens (Human) 308 negative regulation of cell growth [GO:0030308]; small GTPase mediated signal transduction [GO:0007264] GO:0003924; GO:0005525; GO:0005622; GO:0005886; GO:0007264; GO:0030308 0 0 0 PF00071; Q06852 CHOYP_SSPO.11.14 m.53093 sp SLAP1_CLOTH 58.559 555 158 47 322 816 1474 2016 9.05E-57 223 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q566C8 CHOYP_LOC100366291.1.1 m.21790 sp ANR54_RAT 58.667 75 31 0 102 176 104 178 9.05E-23 95.1 ANR54_RAT reviewed Ankyrin repeat domain-containing protein 54 Ankrd54 Rattus norvegicus (Rat) 299 positive regulation of erythrocyte differentiation [GO:0045648]; regulation of intracellular signal transduction [GO:1902531] GO:0005634; GO:0005737; GO:0030496; GO:0045648; GO:1902531 0 0 0 0 Q8R3G1 CHOYP_LOC100113671.1.1 m.18491 sp PP1R8_MOUSE 55.394 343 133 10 35 362 14 351 9.05E-122 358 PP1R8_MOUSE reviewed Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) Ppp1r8 Nipp1 Mus musculus (Mouse) 351 "cell proliferation [GO:0008283]; mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0004864; GO:0005654; GO:0005681; GO:0006351; GO:0006355; GO:0006397; GO:0007275; GO:0008283; GO:0008380; GO:0008599; GO:0016607 0 0 0 PF00498; Q99M80 CHOYP_LOC100208023.4.8 m.40213 sp PTPRT_MOUSE 28.182 550 368 12 439 974 882 1418 9.05E-59 224 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; O70277 CHOYP_BRAFLDRAFT_87311.2.2 m.48296 sp TRIM3_RAT 24.561 285 192 11 105 375 467 742 9.06E-11 67 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P51948 CHOYP_LOC100367313.1.1 m.62971 sp MAT1_HUMAN 51.623 308 145 2 10 314 2 308 9.06E-106 314 MAT1_HUMAN reviewed CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36) MNAT1 CAP35 MAT1 RNF66 Homo sapiens (Human) 309 "7-methylguanosine mRNA capping [GO:0006370]; adult heart development [GO:0007512]; cell proliferation [GO:0008283]; DNA repair [GO:0006281]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein complex assembly [GO:0006461]; protein phosphorylation [GO:0006468]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to calcium ion [GO:0051592]; termination of RNA polymerase I transcription [GO:0006363]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription initiation from RNA polymerase I promoter [GO:0006361]; ventricular system development [GO:0021591]" GO:0000079; GO:0000082; GO:0000086; GO:0005654; GO:0005675; GO:0005737; GO:0006281; GO:0006283; GO:0006294; GO:0006357; GO:0006361; GO:0006362; GO:0006363; GO:0006366; GO:0006367; GO:0006368; GO:0006370; GO:0006461; GO:0006468; GO:0007512; GO:0008270; GO:0008283; GO:0021591; GO:0043066; GO:0045944; GO:0047485; GO:0048661; GO:0051592 0 0 0 PF06391;PF17121; P53565 CHOYP_CUX1.2.2 m.43732 sp CUX1_RAT 48.116 690 318 9 11 669 1 681 9.06E-180 580 CUX1_RAT reviewed Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP2) (Homeobox protein cux-1) Cux1 Cdpl1 Cutl1 Rattus norvegicus (Rat) 1504 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; transcription, DNA-templated [GO:0006351]" GO:0000139; GO:0000301; GO:0005654; GO:0006351; GO:0006355; GO:0007275; GO:0030674; GO:0043565 0 0 0 PF02376;PF00046; Q06852 CHOYP_contig_003244 m.3625 sp SLAP1_CLOTH 31.818 396 253 6 196 581 1373 1761 9.06E-12 72.8 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q08CG8 CHOYP_LCHN.1.2 m.59461 sp RNF44_DANRE 41.304 92 53 1 486 577 347 437 9.06E-19 92.8 RNF44_DANRE reviewed RING finger protein 44 rnf44 zgc:153103 Danio rerio (Zebrafish) (Brachydanio rerio) 448 "proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005654; GO:0005737; GO:0006355; GO:0008270; GO:0043161; GO:0061630 0 0 0 PF13639; Q26473 CHOYP_SEM1A.2.2 m.58349 sp SEM1A_SCHAM 41.97 660 336 18 25 656 18 658 9.06E-166 498 SEM1A_SCHAM reviewed Semaphorin-1A (Fasciclin IV) (Fasciclin-4) (Semaphorin-I) (Sema I) SEMA-1A FAS4 Schistocerca americana (American grasshopper) 730 cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0007399; GO:0016021; GO:0030154 0 0 0 PF01403; Q868Z9 CHOYP_LOC100871073.1.1 m.59149 sp PPN_DROME 31.935 620 316 16 207 771 1611 2179 9.06E-85 300 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q8BXA0 CHOYP_CAOG_06642.1.1 m.14688 sp LRFN5_MOUSE 26.923 260 163 6 26 272 3 248 9.06E-19 95.5 LRFN5_MOUSE reviewed Leucine-rich repeat and fibronectin type-III domain-containing protein 5 Lrfn5 Kiaa4208 Salm5 Mus musculus (Mouse) 719 0 GO:0009986; GO:0016021 0 0 0 PF07679;PF13306; Q8C1Q4 CHOYP_METRL.1.1 m.57181 sp METRN_MOUSE 27.273 275 184 7 30 298 26 290 9.06E-18 84.7 METRN_MOUSE reviewed Meteorin (Hypoxia/reoxygenation regulatory factor) Metrn Hyrac Mus musculus (Mouse) 291 glial cell differentiation [GO:0010001]; positive regulation of axonogenesis [GO:0050772] GO:0005615; GO:0010001; GO:0050772 0 0 0 0 Q8IWQ3 CHOYP_BRSK2.1.2 m.31318 sp BRSK2_HUMAN 46.929 407 161 12 1 374 250 634 9.06E-102 322 BRSK2_HUMAN reviewed Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 Homo sapiens (Human) 736 "actin cytoskeleton reorganization [GO:0031532]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitotic nuclear division [GO:0007067]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of ATPase activity [GO:0043462]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]" GO:0000086; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005813; GO:0006468; GO:0006887; GO:0007067; GO:0007409; GO:0018105; GO:0030010; GO:0030182; GO:0031532; GO:0036503; GO:0043462; GO:0048471; GO:0050321; GO:0051117; GO:0051301; GO:0060590; GO:0061178; GO:0070059; GO:1904152 0 0 0 PF00069; Q8NEZ4 CHOYP_LOC591084.1.2 m.52367 sp KMT2C_HUMAN 35.618 817 433 24 893 1651 924 1705 9.06E-131 469 KMT2C_HUMAN reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) KMT2C HALR KIAA1506 MLL3 Homo sapiens (Human) 4911 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0008270; GO:0016746; GO:0018024; GO:0035097; GO:0042800; GO:0044666; GO:0044822 0 0 0 PF05965;PF05964;PF00628;PF00856; Q8YWD8 CHOYP_LOC100704562.1.1 m.25340 sp MSRA2_NOSS1 67.788 208 67 0 7 214 9 216 9.06E-106 306 MSRA2_NOSS1 reviewed Peptide methionine sulfoxide reductase MsrA 2 (Protein-methionine-S-oxide reductase 2) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase 2) (Peptide Met(O) reductase 2) msrA2 alr1675 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 222 cellular protein modification process [GO:0006464]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979] GO:0006464; GO:0006979; GO:0008113; GO:0030091 0 0 0 PF01625; Q9HCU4 CHOYP_FAT4.10.10 m.58190 sp CELR2_HUMAN 29.565 345 215 11 5 340 582 907 9.06E-27 115 CELR2_HUMAN reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) 2923 "dendrite morphogenesis [GO:0048813]; G-protein coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0007186; GO:0007283; GO:0016021; GO:0016055; GO:0021999; GO:0022407; GO:0048813; GO:0060071 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF12661;PF00053;PF02210; Q9UK96 CHOYP_FBX10.1.1 m.35917 sp FBX10_HUMAN 39.404 604 331 12 573 1159 353 938 9.06E-125 410 FBX10_HUMAN reviewed F-box only protein 10 FBXO10 FBX10 PRMT11 Homo sapiens (Human) 956 apoptotic process [GO:0006915]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of apoptotic process [GO:0042981] GO:0000151; GO:0004842; GO:0005737; GO:0006915; GO:0016567; GO:0042787; GO:0042981 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937;PF05048; Q9VFJ2 CHOYP_RM11.1.1 m.9390 sp RM11_DROME 48.718 195 97 3 23 217 3 194 9.06E-58 184 RM11_DROME reviewed "39S ribosomal protein L11, mitochondrial (L11mt) (MRP-L11)" mRpL11 CG3351 Drosophila melanogaster (Fruit fly) 196 gene silencing by RNA [GO:0031047]; regulation of translation [GO:0006417]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005762; GO:0006412; GO:0006417; GO:0019843; GO:0031047 0 0 cd00349; PF00298;PF03946; O22558 CHOYP_BRAFLDRAFT_81321.5.10 m.45062 sp STY8_ARATH 28.839 267 154 13 731 992 291 526 9.07E-24 110 STY8_ARATH reviewed Serine/threonine-protein kinase STY8 (EC 2.7.11.1) (Serine/threonine/tyrosine-protein kinase 8) STY8 At2g17700 Arabidopsis thaliana (Mouse-ear cress) 546 chloroplast organization [GO:0009658] GO:0004674; GO:0004712; GO:0005524; GO:0005829; GO:0009658; GO:0016597 0 0 0 PF07714; O94827 CHOYP_LOC101070578.1.1 m.19751 sp PKHG5_HUMAN 33.019 212 114 7 25 234 12 197 9.07E-25 105 PKHG5_HUMAN reviewed Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720) PLEKHG5 KIAA0720 Homo sapiens (Human) 1062 endothelial cell chemotaxis [GO:0035767]; positive regulation of apoptotic process [GO:0043065]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0004871; GO:0005085; GO:0005089; GO:0005737; GO:0005829; GO:0005886; GO:0005911; GO:0030027; GO:0030139; GO:0035023; GO:0035767; GO:0043065; GO:0043123; GO:0048471; GO:0051056 0 0 0 PF00621; P0CH27 CHOYP_LINJ_09_0950.1.1 m.64023 sp RL402_TRYCR 60.473 296 27 2 1 206 61 356 9.07E-112 326 RL402_TRYCR reviewed Ubiquitin-60S ribosomal protein L40 [Cleaved into: Ubiquitin; 60S ribosomal protein L40] 0 Trypanosoma cruzi 356 translation [GO:0006412] GO:0003735; GO:0005634; GO:0005840; GO:0006412 0 0 0 PF01020;PF00240; P20825 CHOYP_CRE_06930.1.1 m.36963 sp POL2_DROME 41.152 243 135 3 246 483 163 402 9.07E-51 189 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P34501 CHOYP_BRAFLDRAFT_68804.1.1 m.53566 sp YMS5_CAEEL 26.082 970 550 44 25 875 332 1253 9.07E-61 231 YMS5_CAEEL reviewed Uncharacterized protein K03H1.5 K03H1.5 Caenorhabditis elegans 1385 cell-matrix adhesion [GO:0007160] GO:0007160 0 0 0 PF03782;PF06119;PF00084;PF00094; P42674 CHOYP_LOC100377541.1.4 m.12522 sp BP10_PARLI 30.488 328 194 12 93 401 45 357 9.07E-33 133 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; Q1HPL8 CHOYP_TSP_01008.2.3 m.19375 sp NDUBA_BOMMO 47.692 65 32 1 12 76 33 95 9.07E-14 67 NDUBA_BOMMO reviewed NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0 Bombyx mori (Silk moth) 159 oxidation-reduction process [GO:0055114] GO:0005743; GO:0055114; GO:0070469 0 0 0 PF10249; Q58DT5 CHOYP_BRAFLDRAFT_91068.1.1 m.9955 sp ELMD3_BOVIN 43.45 313 167 3 305 613 30 336 9.07E-82 266 ELMD3_BOVIN reviewed ELMO domain-containing protein 3 (RNA-binding motif and ELMO domain-containing protein 1) ELMOD3 RBED1 Bos taurus (Bovine) 381 0 GO:0005737; GO:0005856; GO:0032420; GO:0060091 0 0 0 PF04727; Q5GLH2 CHOYP_NEMVEDRAFT_V1G97278.1.2 m.34547 sp TRIB2_BOVIN 55.46 348 141 8 1 340 1 342 9.07E-129 374 TRIB2_BOVIN reviewed Tribbles homolog 2 (TRB-2) TRIB2 Bos taurus (Bovine) 343 negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-10 biosynthetic process [GO:0045081]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405] GO:0004860; GO:0005634; GO:0005737; GO:0005856; GO:0031434; GO:0032436; GO:0043405; GO:0045081; GO:0045599; GO:0055106 0 0 0 PF00069; Q5R4U0 CHOYP_LOC100120246.1.1 m.4507 sp CAH10_PONAB 37.019 208 123 4 1 201 122 328 9.07E-49 164 CAH10_PONAB reviewed Carbonic anhydrase-related protein 10 CA10 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 328 0 0 0 0 0 PF00194; Q61425 CHOYP_ND1.2.5 m.36938 sp HCDH_MOUSE 67.832 286 91 1 63 347 29 314 9.07E-139 399 HCDH_MOUSE reviewed "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)" Hadh Hadhsc Mschad Schad Mus musculus (Mouse) 314 fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to insulin [GO:0032868] GO:0003857; GO:0005654; GO:0005737; GO:0005739; GO:0005743; GO:0005759; GO:0006635; GO:0014823; GO:0032868; GO:0042493; GO:0046676; GO:0070403 PATHWAY: Lipid metabolism; fatty acid beta-oxidation. 0 0 PF00725;PF02737; Q64424 CHOYP_BRAFLDRAFT_225844.2.2 m.57508 sp LIPR2_MYOCO 39.809 314 164 7 12 302 46 357 9.07E-59 198 LIPR2_MYOCO reviewed Pancreatic lipase-related protein 2 (PL-RP2) (EC 3.1.1.26) (EC 3.1.1.3) (Galactolipase) PNLIPRP2 Myocastor coypus (Coypu) (Nutria) 470 galactolipid catabolic process [GO:0019376]; phospholipid catabolic process [GO:0009395] GO:0004620; GO:0004806; GO:0005509; GO:0005615; GO:0009395; GO:0019376; GO:0047372; GO:0047714 0 0 0 PF00151;PF01477; Q8LGG8 CHOYP_LOC100185549.1.6 m.31232 sp USPAL_ARATH 27.465 142 90 4 37 166 19 159 9.07E-13 66.2 USPAL_ARATH reviewed Universal stress protein A-like protein At3g01520 F4P13.7 Arabidopsis thaliana (Mouse-ear cress) 175 response to stress [GO:0006950] GO:0005886; GO:0006950; GO:0016208 0 0 0 PF00582; Q9HAB8 CHOYP_BRAFLDRAFT_282135.1.1 m.55919 sp PPCS_HUMAN 48.364 275 140 1 33 305 34 308 9.07E-92 278 PPCS_HUMAN reviewed Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) PPCS COAB Homo sapiens (Human) 311 coenzyme A biosynthetic process [GO:0015937]; coenzyme biosynthetic process [GO:0009108] GO:0004632; GO:0005829; GO:0009108; GO:0015937; GO:0070062 PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5. 0 0 PF04127; Q9NRA8 CHOYP_4ET.1.1 m.1941 sp 4ET_HUMAN 31.23 634 311 26 38 657 30 552 9.07E-37 152 4ET_HUMAN reviewed Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) EIF4ENIF1 Homo sapiens (Human) 985 negative regulation of neuron differentiation [GO:0045665]; negative regulation of translation [GO:0017148]; stem cell population maintenance [GO:0019827] GO:0000932; GO:0003729; GO:0005634; GO:0005737; GO:0005829; GO:0008565; GO:0016020; GO:0016605; GO:0016607; GO:0017148; GO:0019827; GO:0043231; GO:0044822; GO:0045665 0 0 0 PF10477; Q9Y2W6 CHOYP_TDRKH.1.1 m.8335 sp TDRKH_HUMAN 36.283 452 217 15 51 445 55 492 9.07E-73 242 TDRKH_HUMAN reviewed Tudor and KH domain-containing protein (Tudor domain-containing protein 2) TDRKH TDRD2 Homo sapiens (Human) 561 cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiosis [GO:0007140]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283] GO:0003723; GO:0005739; GO:0007140; GO:0007283; GO:0009566; GO:0030154; GO:0031047; GO:0034587; GO:0043046; GO:0071546; GO:0071547 0 0 0 PF00013;PF00567; A8IHN8 CHOYP_contig_000437 m.416 sp CK096_RAT 50.98 51 21 2 40 90 164 210 9.08E-06 47.8 CK096_RAT reviewed Uncharacterized protein C11orf96 homolog (Protein Ag2) Ag2 Rattus norvegicus (Rat) 242 0 0 0 0 0 PF15766; O70277 CHOYP_BRAFLDRAFT_211053.1.2 m.42405 sp TRIM3_RAT 27.551 196 126 5 3 192 544 729 9.08E-11 63.5 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; Q17QS6 CHOYP_AASI_1435.17.35 m.39922 sp ASB5_BOVIN 29.891 184 122 4 35 215 87 266 9.08E-16 77.8 ASB5_BOVIN reviewed Ankyrin repeat and SOCS box protein 5 (ASB-5) ASB5 Bos taurus (Bovine) 329 intracellular signal transduction [GO:0035556]; protein ubiquitination [GO:0016567] GO:0005622; GO:0016567; GO:0035556 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF07525; Q91YK0 CHOYP_BRAFLDRAFT_67566.1.4 m.3 sp LRC49_MOUSE 32.456 114 72 2 145 253 569 682 9.08E-10 62 LRC49_MOUSE reviewed Leucine-rich repeat-containing protein 49 (Tubulin polyglutamylase complex subunit 4) (PGs4) (p79) Lrrc49 Mus musculus (Mouse) 686 0 GO:0005737; GO:0005874 0 0 0 0 A1A4J8 CHOYP_LOC657827.1.1 m.26986 sp SCO1_BOVIN 50.485 206 102 0 70 275 96 301 9.09E-73 228 SCO1_BOVIN reviewed "Protein SCO1 homolog, mitochondrial" SCO1 SCOD1 Bos taurus (Bovine) 305 0 GO:0005739; GO:0030016; GO:0046872; GO:0072492 0 0 cd02968; PF02630; P12970 CHOYP_RL7A.3.6 m.14639 sp RL7A_MOUSE 77.778 54 12 0 31 84 26 79 9.09E-25 97.1 RL7A_MOUSE reviewed 60S ribosomal protein L7a (Surfeit locus protein 3) Rpl7a Surf-3 Surf3 Mus musculus (Mouse) 266 maturation of LSU-rRNA [GO:0000470]; translation [GO:0006412] GO:0000470; GO:0003723; GO:0005634; GO:0005730; GO:0005737; GO:0005925; GO:0006412; GO:0016020; GO:0022625; GO:0042788; GO:0044822; GO:0070062 0 0 0 PF01248; P24733 CHOYP_ISCW_ISCW001340.1.1 m.1978 sp MYS_ARGIR 69.688 353 107 0 45 397 1439 1791 9.09E-156 486 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; Q11174 CHOYP_CRE_00013.1.1 m.30656 sp CHIT_CAEEL 31.481 54 37 0 26 79 481 534 9.09E-06 47.8 CHIT_CAEEL reviewed Probable endochitinase (EC 3.2.1.14) cht-1 C04F6.3 Caenorhabditis elegans 617 chitin catabolic process [GO:0006032]; polysaccharide catabolic process [GO:0000272]; response to fungus [GO:0009620] GO:0000272; GO:0004568; GO:0005576; GO:0005737; GO:0006032; GO:0008061; GO:0009620 0 0 0 PF01607;PF00704; Q5BIM1 CHOYP_BRAFLDRAFT_80577.2.6 m.24330 sp TRI45_BOVIN 25.828 302 167 14 13 274 16 300 9.09E-15 78.2 TRI45_BOVIN reviewed Tripartite motif-containing protein 45 TRIM45 Bos taurus (Bovine) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q5R839 CHOYP_LOC100372696.2.2 m.49102 sp S41A1_PONAB 48.352 91 39 2 103 193 59 141 9.09E-15 75.1 S41A1_PONAB reviewed Solute carrier family 41 member 1 SLC41A1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 513 0 GO:0005886; GO:0008324; GO:0016021 0 0 0 PF01769; Q63ZZ0 CHOYP_TM242.1.1 m.9029 sp TM242_XENLA 29.661 118 77 2 43 156 28 143 9.09E-11 60.1 TM242_XENLA reviewed Transmembrane protein 242 tmem242 Xenopus laevis (African clawed frog) 145 0 GO:0016021 0 0 0 PF07096; Q80YX1 CHOYP_LOC100633103.1.1 m.58167 sp TENA_MOUSE 44.144 111 57 3 1 111 1992 2097 9.09E-25 100 TENA_MOUSE reviewed Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) Tnc Hxb Mus musculus (Mouse) 2110 bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060] GO:0001649; GO:0001968; GO:0005576; GO:0005604; GO:0005614; GO:0005615; GO:0005925; GO:0007155; GO:0007162; GO:0007528; GO:0008284; GO:0009612; GO:0010628; GO:0014012; GO:0016020; GO:0031012; GO:0042060; GO:0042475; GO:0045471; GO:0045545; GO:0060447; GO:0060739; GO:0060740; GO:0071300; GO:0071305; GO:0071774; GO:0071799 0 0 0 PF07974;PF00147;PF00041; F7DL67 CHOYP_NNRE.1.2 m.3266 sp NNRE_XENTR 63.415 123 45 0 1 123 169 291 9.10E-53 171 NNRE_XENTR reviewed NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I binding protein) (NAD(P)HX epimerase) naxe apoa1bp Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 292 0 GO:0000166; GO:0005576; GO:0005739; GO:0046872; GO:0052856; GO:0052857 0 0 0 PF03853; P0C6B1 CHOYP_LOC100206475.1.16 m.4005 sp S35E1_RAT 39.355 155 81 4 3 155 247 390 9.10E-25 102 S35E1_RAT reviewed Solute carrier family 35 member E1 Slc35e1 Rattus norvegicus (Rat) 409 carbohydrate transmembrane transport [GO:0034219] GO:0016021; GO:0034219 0 0 0 PF03151; P49183 CHOYP_LOC100367531.1.1 m.29477 sp DNAS1_MOUSE 43.726 263 140 3 32 289 23 282 9.10E-65 212 DNAS1_MOUSE reviewed Deoxyribonuclease-1 (EC 3.1.21.1) (Deoxyribonuclease I) (DNase I) Dnase1 Dnl1 Mus musculus (Mouse) 284 apoptotic process [GO:0006915]; DNA catabolic process [GO:0006308] GO:0004530; GO:0005634; GO:0005635; GO:0006308; GO:0006915; GO:0070062 0 0 0 0 P58929 CHOYP_BRAFLDRAFT_119363.1.1 m.41628 sp GMEB2_MOUSE 36.449 107 67 1 25 131 91 196 9.10E-21 92.8 GMEB2_MOUSE reviewed Glucocorticoid modulatory element-binding protein 2 (GMEB-2) Gmeb2 Mus musculus (Mouse) 530 "regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003713; GO:0005634; GO:0005654; GO:0005737; GO:0006351; GO:0006357; GO:0046872 0 0 0 PF01342; Q14149 CHOYP_MORC3.2.2 m.66674 sp MORC3_HUMAN 54.227 485 196 11 59 533 14 482 9.10E-164 502 MORC3_HUMAN reviewed MORC family CW-type zinc finger protein 3 (Nuclear matrix protein 2) (Zinc finger CW-type coiled-coil domain protein 3) MORC3 KIAA0136 NXP2 ZCWCC3 Homo sapiens (Human) 939 cell aging [GO:0007569]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of fibroblast proliferation [GO:0048147]; peptidyl-serine phosphorylation [GO:0018105]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; viral process [GO:0016032] GO:0003723; GO:0005654; GO:0006468; GO:0007569; GO:0008270; GO:0009791; GO:0016032; GO:0016363; GO:0016605; GO:0018105; GO:0048147; GO:0050821; GO:0051457 0 0 0 PF07496; Q5XGW6 CHOYP_LOC100367460.1.1 m.62926 sp CHM4B_XENLA 67.556 225 69 3 36 260 1 221 9.10E-88 263 CHM4B_XENLA reviewed Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) chmp4b Xenopus laevis (African clawed frog) 222 exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; mitotic cytokinesis [GO:0000281]; nuclear envelope reassembly [GO:0031468]; protein transport [GO:0015031]; vacuolar transport [GO:0007034] GO:0000281; GO:0000815; GO:0005635; GO:0005829; GO:0007034; GO:0010458; GO:0015031; GO:0030496; GO:0031468; GO:0031902; GO:0090148 0 0 0 PF03357; Q6MG64 CHOYP_BRAFLDRAFT_63397.8.8 m.66251 sp VWA7_RAT 26.304 460 272 15 80 525 90 496 9.10E-33 136 VWA7_RAT reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) 892 0 GO:0005576 0 0 0 0 Q6NXH2 CHOYP_LOC100718937.1.1 m.13522 sp MANEA_MOUSE 58.357 353 146 1 104 456 98 449 9.10E-155 450 MANEA_MOUSE reviewed "Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha mannosidase) (Endomannosidase) (mEndo) (EC 3.2.1.130)" Manea Mus musculus (Mouse) 462 0 GO:0000139; GO:0004569; GO:0005794; GO:0016021 0 0 cd11574; PF16317; Q6P2X9 CHOYP_BRAFLDRAFT_72777.1.1 m.873 sp MOT12_XENTR 25.952 420 295 4 15 418 9 428 9.10E-47 171 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6RY07 CHOYP_BRAFLDRAFT_281651.1.8 m.2537 sp CHIA_RAT 50.126 397 182 5 68 456 19 407 9.10E-137 405 CHIA_RAT reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) 473 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532] GO:0000272; GO:0002376; GO:0002532; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0006032; GO:0006915; GO:0008061; GO:0090197 0 0 0 PF01607;PF00704; Q8ITC7 CHOYP_LOC100888779.1.1 m.33237 sp CAPAR_DROME 26.636 214 137 8 43 245 83 287 9.10E-06 51.2 CAPAR_DROME reviewed Neuropeptides capa receptor (Cap2b receptor) (Capability receptor) CapaR CG14575 Drosophila melanogaster (Fruit fly) 477 body fluid secretion [GO:0007589]; cellular response to desiccation [GO:0071465]; G-protein coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of calcium ion transport [GO:0051928] GO:0001607; GO:0007186; GO:0007218; GO:0007589; GO:0008188; GO:0016021; GO:0016323; GO:0051928; GO:0071465 0 0 0 PF00001; Q8VHI3 CHOYP_LOC100368416.1.1 m.58347 sp OFUT2_MOUSE 54.846 423 185 4 16 434 6 426 9.10E-162 465 OFUT2_MOUSE reviewed GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2) Pofut2 Mus musculus (Mouse) 429 fucose metabolic process [GO:0006004]; fucosylation [GO:0036065]; mesoderm formation [GO:0001707]; protein O-linked fucosylation [GO:0036066]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046] GO:0001707; GO:0005783; GO:0005794; GO:0006004; GO:0008417; GO:0010468; GO:0010717; GO:0036065; GO:0036066; GO:0046922; GO:0051046 PATHWAY: Protein modification; protein glycosylation. 0 0 PF10250; Q91VS8 CHOYP_LOC100690924.1.1 m.59314 sp FARP2_MOUSE 52.542 295 138 2 367 660 514 807 9.10E-93 312 FARP2_MOUSE reviewed "FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR)" Farp2 Kiaa0793 Mus musculus (Mouse) 1065 actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; neuron remodeling [GO:0016322]; osteoclast differentiation [GO:0030316]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; regulation of integrin activation [GO:0033623]; regulation of Rho protein signal transduction [GO:0035023]; semaphorin-plexin signaling pathway [GO:0071526] GO:0005089; GO:0005737; GO:0005829; GO:0005856; GO:0007155; GO:0016322; GO:0016601; GO:0019898; GO:0030316; GO:0030676; GO:0031532; GO:0033623; GO:0035023; GO:0071526; GO:0071800 0 0 0 PF08736;PF09380;PF00373;PF09379;PF00169;PF00621; Q99571 CHOYP_LOC100533332.1.1 m.35098 sp P2RX4_HUMAN 48.919 370 175 7 24 386 10 372 9.10E-125 368 P2RX4_HUMAN reviewed P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) P2RX4 Homo sapiens (Human) 388 apoptotic signaling pathway [GO:0097190]; blood coagulation [GO:0007596]; cellular response to ATP [GO:0071318]; endothelial cell activation [GO:0042118]; ion transmembrane transport [GO:0034220]; membrane depolarization [GO:0051899]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; neuronal action potential [GO:0019228]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of prostaglandin secretion [GO:0032308]; protein homooligomerization [GO:0051260]; purinergic nucleotide receptor signaling pathway [GO:0035590]; regulation of blood pressure [GO:0008217]; regulation of cardiac muscle contraction [GO:0055117]; regulation of sodium ion transport [GO:0002028]; relaxation of cardiac muscle [GO:0055119]; response to ATP [GO:0033198]; response to fluid shear stress [GO:0034405]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; tissue homeostasis [GO:0001894]; transport [GO:0006810] GO:0001614; GO:0001894; GO:0002028; GO:0004931; GO:0005102; GO:0005507; GO:0005524; GO:0005639; GO:0005765; GO:0005886; GO:0005887; GO:0006810; GO:0007165; GO:0007596; GO:0008144; GO:0008217; GO:0008270; GO:0010524; GO:0010614; GO:0014069; GO:0016020; GO:0019228; GO:0019233; GO:0030054; GO:0032308; GO:0033198; GO:0034220; GO:0034405; GO:0035590; GO:0042118; GO:0042803; GO:0043025; GO:0043195; GO:0043197; GO:0045296; GO:0045429; GO:0048471; GO:0050850; GO:0051260; GO:0051899; GO:0051928; GO:0055117; GO:0055119; GO:0070062; GO:0071318; GO:0097190 0 0 0 PF00864; F1NW29 CHOYP_TYDP2.1.1 m.45143 sp TYDP2_CHICK 40.945 254 146 3 18 270 112 362 9.11E-61 199 TYDP2_CHICK reviewed Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) TDP2 Gallus gallus (Chicken) 369 double-strand break repair [GO:0006302]; multicellular organism development [GO:0007275] GO:0000287; GO:0003697; GO:0004518; GO:0005737; GO:0006302; GO:0007275; GO:0016605; GO:0030145; GO:0036317; GO:0045171; GO:0070260 0 0 0 0 O95198 CHOYP_LOC100375441.1.1 m.10519 sp KLHL2_HUMAN 25.21 357 232 7 68 409 47 383 9.11E-29 125 KLHL2_HUMAN reviewed Kelch-like protein 2 (Actin-binding protein Mayven) KLHL2 Homo sapiens (Human) 593 protein ubiquitination [GO:0016567] GO:0001726; GO:0003779; GO:0005737; GO:0005829; GO:0015629; GO:0016567; GO:0030027; GO:0031463 0 0 0 PF07707;PF00651;PF01344; P16157 CHOYP_TVAG_168010.7.45 m.22444 sp ANK1_HUMAN 33.651 630 390 7 142 766 66 672 9.11E-86 301 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P19217 CHOYP_ST1E1.1.2 m.1208 sp ST1E1_BOVIN 32.877 219 139 5 1 219 82 292 9.11E-31 117 ST1E1_BOVIN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) 295 estrogen metabolic process [GO:0008210] GO:0004304; GO:0005496; GO:0005737; GO:0008210; GO:0050294 0 0 0 PF00685; P22031 CHOYP_LOC101166129.1.1 m.5194 sp LEG_HELCR 43.956 91 49 1 129 217 12 102 9.11E-20 85.1 LEG_HELCR reviewed D-galactoside-specific lectin (Sea urchin egg lectin) (SUEL) 0 Heliocidaris crassispina (Sea urchin) (Anthocidaris crassispina) 105 0 GO:0005737; GO:0030246 0 0 0 PF02140; Q1RMU8 CHOYP_LOC100331465.3.3 m.48126 sp NPY1R_BOVIN 28.139 231 139 9 35 252 42 258 9.11E-08 57 NPY1R_BOVIN reviewed Neuropeptide Y receptor type 1 (NPY1-R) NPY1R Bos taurus (Bovine) 383 blood circulation [GO:0008015]; cell surface receptor signaling pathway [GO:0007166]; feeding behavior [GO:0007631]; glucose metabolic process [GO:0006006]; locomotory behavior [GO:0007626]; neuropeptide signaling pathway [GO:0007218]; outflow tract morphogenesis [GO:0003151]; regulation of blood pressure [GO:0008217]; regulation of multicellular organism growth [GO:0040014]; sensory perception of pain [GO:0019233] GO:0001601; GO:0001602; GO:0003151; GO:0005887; GO:0006006; GO:0007166; GO:0007218; GO:0007626; GO:0007631; GO:0008015; GO:0008217; GO:0019233; GO:0040014 0 0 0 PF00001; Q2M1K9 CHOYP_BRAFLDRAFT_119633.1.1 m.54886 sp ZN423_HUMAN 30.709 127 80 3 398 521 222 343 9.11E-07 56.2 ZN423_HUMAN reviewed Zinc finger protein 423 (Olf1/EBF-associated zinc finger protein) (hOAZ) (Smad- and Olf-interacting zinc finger protein) ZNF423 KIAA0760 NPHP14 OAZ Homo sapiens (Human) 1284 "cell differentiation [GO:0030154]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0007219; GO:0007399; GO:0030154; GO:0030513; GO:0045892; GO:0045893; GO:0046872 0 0 0 PF13912; Q5ND28 CHOYP_MEGF10.7.12 m.37901 sp SREC_MOUSE 35.349 215 129 9 176 388 194 400 9.11E-21 99.8 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q80V70 CHOYP_LOC100911486.1.1 m.21165 sp MEGF6_MOUSE 36.145 83 49 2 2 84 1112 1190 9.11E-07 54.7 MEGF6_MOUSE reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) Megf6 Egfl3 Mus musculus (Mouse) 1572 0 GO:0005509; GO:0005576 0 0 0 PF12662;PF07974;PF07645;PF12661;PF00053; Q8IN35 CHOYP_LOC100372174.2.2 m.46332 sp SIFAR_DROME 25.949 316 200 12 30 325 203 504 9.11E-24 105 SIFAR_DROME reviewed Neuropeptide SIFamide receptor SIFaR SIFR CG10823 Drosophila melanogaster (Fruit fly) 758 "determination of adult lifespan [GO:0008340]; G-protein coupled receptor signaling pathway [GO:0007186]; mating behavior, sex discrimination [GO:0048047]; neuropeptide signaling pathway [GO:0007218]; sensory perception of pain [GO:0019233]" GO:0004930; GO:0004983; GO:0005887; GO:0007186; GO:0007218; GO:0008188; GO:0008340; GO:0008528; GO:0016021; GO:0019233; GO:0048047 0 0 0 PF00001; Q8TD10 CHOYP_LOC578530.1.1 m.10573 sp MIPO1_HUMAN 30.904 343 205 7 369 690 104 435 9.11E-34 138 MIPO1_HUMAN reviewed Mirror-image polydactyly gene 1 protein MIPOL1 Homo sapiens (Human) 442 0 GO:0005634 0 0 0 0 Q9HCU4 CHOYP_LOC100369879.1.3 m.35102 sp CELR2_HUMAN 27.48 615 377 26 220 790 308 897 9.11E-21 102 CELR2_HUMAN reviewed Cadherin EGF LAG seven-pass G-type receptor 2 (Cadherin family member 10) (Epidermal growth factor-like protein 2) (EGF-like protein 2) (Flamingo homolog 3) (Multiple epidermal growth factor-like domains protein 3) (Multiple EGF-like domains protein 3) CELSR2 CDHF10 EGFL2 KIAA0279 MEGF3 Homo sapiens (Human) 2923 "dendrite morphogenesis [GO:0048813]; G-protein coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; neural plate anterior/posterior regionalization [GO:0021999]; regulation of cell-cell adhesion [GO:0022407]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0004930; GO:0005509; GO:0005737; GO:0005886; GO:0006355; GO:0007156; GO:0007186; GO:0007283; GO:0016021; GO:0016055; GO:0021999; GO:0022407; GO:0048813; GO:0060071 0 0 0 PF00002;PF00028;PF00008;PF16489;PF01825;PF12661;PF00053;PF02210; L7YAI7 CHOYP_B3GNT1.1.1 m.10648 sp B4GA1_DANRE 37.017 362 200 10 60 397 74 431 9.12E-76 244 B4GA1_DANRE reviewed "Beta-1,4-glucuronyltransferase 1 (EC 2.4.1.-) (I-beta-1,3-N-acetylglucosaminyltransferase) (N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase) (Poly-N-acetyllactosamine extension enzyme) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1)" b4gat1 b3gnt1 Danio rerio (Zebrafish) (Brachydanio rerio) 431 muscle fiber development [GO:0048747]; protein glycosylation [GO:0006486]; protein O-linked mannosylation [GO:0035269] GO:0000139; GO:0005794; GO:0006486; GO:0015020; GO:0016021; GO:0035269; GO:0046872; GO:0048747 "PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:O43505, ECO:0000250|UniProtKB:Q8BWP8}." 0 0 0 P10079 CHOYP_LOC582329.2.2 m.38646 sp FBP1_STRPU 47.196 214 109 3 74 285 378 589 9.12E-52 186 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; Q06852 CHOYP_contig_033736 m.38357 sp SLAP1_CLOTH 59.048 105 32 8 4 99 1388 1490 9.12E-07 52.4 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q13439 CHOYP_GOLGA4.3.3 m.55461 sp GOGA4_HUMAN 32.084 667 383 18 9 651 30 650 9.12E-56 219 GOGA4_HUMAN reviewed Golgin subfamily A member 4 (256 kDa golgin) (Golgin-245) (Protein 72.1) (Trans-Golgi p230) GOLGA4 Homo sapiens (Human) 2230 Golgi to plasma membrane protein transport [GO:0043001]; positive regulation of axon extension [GO:0045773]; protein targeting to Golgi [GO:0000042]; vesicle-mediated transport [GO:0016192] GO:0000042; GO:0000139; GO:0005654; GO:0005737; GO:0005794; GO:0005802; GO:0005829; GO:0016192; GO:0043001; GO:0043231; GO:0045773; GO:0051020; GO:0070062 0 0 0 PF01465; Q2PC93 CHOYP_LOC100497129.1.8 m.3163 sp SSPO_CHICK 42 450 231 15 1 439 1157 1587 9.12E-89 330 SSPO_CHICK reviewed SCO-spondin SSPO Gallus gallus (Chicken) 5255 cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399] GO:0005615; GO:0007155; GO:0007399; GO:0030154 0 0 0 PF00754;PF00057;PF01826;PF00090;PF00093;PF00094; Q5UR67 CHOYP_YR617.1.1 m.35828 sp RIBX_MIMIV 46.061 165 78 3 753 906 2 166 9.12E-36 136 RIBX_MIMIV reviewed N-glycosidase R617 (EC 3.2.2.-) (Riboflavin biosynthesis intermediates N-glycosidase) MIMI_R617 Acanthamoeba polyphaga mimivirus (APMV) 170 metabolic process [GO:0008152] GO:0008152; GO:0016798 0 0 cd15457; PF08719; Q76LL8 CHOYP_CRHR.1.2 m.38455 sp CRFR1_MACMU 43.207 368 188 7 63 426 44 394 9.12E-97 300 CRFR1_MACMU reviewed Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) CRHR1 CRF1 Macaca mulatta (Rhesus macaque) 415 cell surface receptor signaling pathway [GO:0007166]; cellular response to corticotropin-releasing hormone stimulus [GO:0071376]; corticotropin secretion [GO:0051458]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; regulation of corticosterone secretion [GO:2000852] GO:0005768; GO:0007166; GO:0010579; GO:0015056; GO:0016021; GO:0031226; GO:0051458; GO:0071376; GO:2000852 0 0 0 PF00002;PF02793; Q86VD9 CHOYP_PIGZ.2.2 m.20119 sp PIGZ_HUMAN 33.532 504 239 12 28 502 37 473 9.12E-53 191 PIGZ_HUMAN reviewed GPI mannosyltransferase 4 (EC 2.4.1.-) (GPI mannosyltransferase IV) (GPI-MT-IV) (Phosphatidylinositol-glycan biosynthesis class Z protein) (PIG-Z) (SMP3 homolog) (hSMP3) PIGZ SMP3 Homo sapiens (Human) 579 GPI anchor biosynthetic process [GO:0006506] GO:0000026; GO:0000030; GO:0005783; GO:0005789; GO:0006506; GO:0016021 PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. 0 0 PF03901; Q92536 CHOYP_LOC100741207.1.1 m.17374 sp YLAT2_HUMAN 37.304 319 194 3 1 319 82 394 9.12E-64 213 YLAT2_HUMAN reviewed "Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)" SLC7A6 KIAA0245 Homo sapiens (Human) 515 amino acid transport [GO:0006865]; cellular amino acid metabolic process [GO:0006520]; leukocyte migration [GO:0050900]; protein complex assembly [GO:0006461]; transport [GO:0006810] GO:0005886; GO:0005887; GO:0006461; GO:0006520; GO:0006810; GO:0006865; GO:0015171; GO:0015179; GO:0015297; GO:0016323; GO:0050900 0 0 0 PF13520; Q9VAI0 CHOYP_LOC692816.1.1 m.28739 sp GNA1_DROME 40.884 181 101 5 38 217 4 179 9.12E-42 144 GNA1_DROME reviewed Probable glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase) CG1969 Drosophila melanogaster (Fruit fly) 219 UDP-N-acetylglucosamine biosynthetic process [GO:0006048] GO:0004343; GO:0006048 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2. 0 0 PF00583; A2AX52 CHOYP_CO6A6.2.3 m.37199 sp CO6A4_MOUSE 22.96 527 357 13 4 511 84 580 9.13E-36 148 CO6A4_MOUSE reviewed Collagen alpha-4(VI) chain Col6a4 Dvwa Mus musculus (Mouse) 2309 cell adhesion [GO:0007155]; protein heterotrimerization [GO:0070208] GO:0005576; GO:0005578; GO:0005581; GO:0007155; GO:0043234; GO:0070208 0 0 0 PF01391;PF00092; O60216 CHOYP_RAD21.1.2 m.45419 sp RAD21_HUMAN 40.909 88 52 0 28 115 314 401 9.13E-14 69.7 RAD21_HUMAN reviewed Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) RAD21 HR21 KIAA0078 NXP1 Homo sapiens (Human) 631 apoptotic process [GO:0006915]; cell division [GO:0051301]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; mitotic nuclear division [GO:0007067]; protein localization to chromatin [GO:0071168]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; sister chromatid cohesion [GO:0007062] GO:0000775; GO:0000785; GO:0001228; GO:0005654; GO:0005694; GO:0005829; GO:0006302; GO:0006310; GO:0006357; GO:0006915; GO:0007062; GO:0007067; GO:0007131; GO:0008278; GO:0016020; GO:0016925; GO:0034991; GO:0051301; GO:0071168 0 0 0 PF04824;PF04825; O75382 CHOYP_BRAFLDRAFT_92727.16.17 m.64617 sp TRIM3_HUMAN 25.984 254 170 8 27 270 458 703 9.13E-09 59.3 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P06734 CHOYP_BRAFLDRAFT_66587.1.1 m.29298 sp FCER2_HUMAN 32.031 128 78 4 131 252 158 282 9.13E-08 57.8 FCER2_HUMAN reviewed Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) (C-type lectin domain family 4 member J) (Fc-epsilon-RII) (Immunoglobulin E-binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form] FCER2 CD23A CLEC4J FCE2 IGEBF Homo sapiens (Human) 321 Notch signaling pathway [GO:0007219]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of killing of cells of other organism [GO:0051712]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770] GO:0002925; GO:0005178; GO:0005886; GO:0005887; GO:0007219; GO:0009897; GO:0030246; GO:0046872; GO:0051000; GO:0051712; GO:0051770; GO:0070062 0 0 0 PF00059; Q5T5X7 CHOYP_LOC101156221.1.1 m.17719 sp BEND3_HUMAN 33 100 64 2 250 348 715 812 9.13E-09 60.8 BEND3_HUMAN reviewed BEN domain-containing protein 3 BEND3 KIAA1553 Homo sapiens (Human) 828 "chromatin modification [GO:0016568]; chromatin silencing at rDNA [GO:0000183]; DNA methylation [GO:0006306]; histone H3-K27 trimethylation [GO:0098532]; histone H3-K4 trimethylation [GO:0080182]; histone H3-K9 trimethylation [GO:0036124]; histone H4 acetylation [GO:0043967]; histone H4-K20 trimethylation [GO:0034773]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000182; GO:0000183; GO:0005720; GO:0005730; GO:0006306; GO:0006351; GO:0016568; GO:0034773; GO:0036124; GO:0043967; GO:0080182; GO:0098532 0 0 0 PF10523; Q6ZRF8 CHOYP_LOC100373444.52.79 m.43017 sp RN207_HUMAN 22.513 191 135 5 1 189 115 294 9.13E-10 63.9 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7T0X5 CHOYP_CHMP7.1.1 m.15221 sp CHMP7_XENLA 29.223 373 252 6 6 375 8 371 9.13E-43 159 CHMP7_XENLA reviewed Charged multivesicular body protein 7 (Chromatin-modifying protein 7) chmp7 Xenopus laevis (African clawed frog) 422 exit from mitosis [GO:0010458]; late endosome to vacuole transport [GO:0045324]; nuclear envelope reassembly [GO:0031468] GO:0000815; GO:0005635; GO:0008565; GO:0010458; GO:0031468; GO:0045324 0 0 0 PF03357; Q9NUJ3 CHOYP_LOC100372245.1.1 m.60270 sp T11L1_HUMAN 40.509 511 284 8 19 516 3 506 9.13E-122 370 T11L1_HUMAN reviewed T-complex protein 11-like protein 1 TCP11L1 Homo sapiens (Human) 509 0 GO:0005874 0 0 0 PF05794; Q9Y2C9 CHOYP_BRAFLDRAFT_87578.1.3 m.34054 sp TLR6_HUMAN 33.019 106 70 1 125 230 641 745 9.13E-08 58.5 TLR6_HUMAN reviewed Toll-like receptor 6 (CD antigen CD286) TLR6 Homo sapiens (Human) 796 activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular response to diacyl bacterial lipopeptide [GO:0071726]; defense response to bacterium [GO:0042742]; detection of diacyl bacterial lipopeptide [GO:0042496]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1 beta secretion [GO:0050702]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; regulation of cytokine secretion [GO:0050707]; signal transduction [GO:0007165]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 6 signaling pathway [GO:0034150]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124] GO:0002224; GO:0002755; GO:0004872; GO:0004888; GO:0005794; GO:0005886; GO:0005887; GO:0006954; GO:0006955; GO:0007165; GO:0007250; GO:0030670; GO:0034150; GO:0035355; GO:0035663; GO:0038124; GO:0042088; GO:0042496; GO:0042742; GO:0043123; GO:0043507; GO:0045087; GO:0045121; GO:0045410; GO:0050702; GO:0050707; GO:0071723; GO:0071726; GO:1900227 0 0 0 PF13855;PF01463;PF01582; Q9Y3B9 CHOYP_LOC100372417.1.1 m.1738 sp RRP15_HUMAN 43.902 205 95 5 18 206 67 267 9.13E-39 137 RRP15_HUMAN reviewed RRP15-like protein (Ribosomal RNA-processing protein 15) RRP15 KIAA0507 CGI-115 Homo sapiens (Human) 282 maturation of 5.8S rRNA [GO:0000460]; maturation of LSU-rRNA [GO:0000470] GO:0000460; GO:0000470; GO:0005634; GO:0005730; GO:0005739; GO:0030687 0 0 0 PF07890; E9Q7T7 CHOYP_contig_001511 m.1609 sp CHADL_MOUSE 27.064 218 114 10 179 371 524 721 9.14E-07 54.3 CHADL_MOUSE reviewed Chondroadherin-like protein Chadl SLRR4B Mus musculus (Mouse) 748 negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of collagen fibril organization [GO:1904027] GO:0005518; GO:0005578; GO:0031012; GO:0032331; GO:0098633; GO:1904027 0 0 0 PF13855;PF01463; O42254 CHOYP_LOC100114171.1.1 m.50280 sp IF2B1_CHICK 35.333 600 342 13 22 601 1 574 9.14E-106 333 IF2B1_CHICK reviewed Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zip-code binding polypeptide) (Zipcode-binding protein 1) (ZBP-1) IGF2BP1 VICKZ1 ZBP1 Gallus gallus (Chicken) 576 CRD-mediated mRNA stabilization [GO:0070934]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; neuronal stem cell population maintenance [GO:0097150]; pallium cell proliferation in forebrain [GO:0022013]; positive regulation of neuron projection development [GO:0010976]; regulation of mRNA stability involved in response to stress [GO:0010610] GO:0000166; GO:0003729; GO:0003730; GO:0005634; GO:0010494; GO:0010610; GO:0010976; GO:0017148; GO:0022013; GO:0030027; GO:0030175; GO:0030426; GO:0045182; GO:0048027; GO:0048471; GO:0051028; GO:0070934; GO:0070937; GO:0097150 0 0 0 PF00013;PF00076; O75382 CHOYP_BRAFLDRAFT_79377.15.30 m.37833 sp TRIM3_HUMAN 24.5 200 131 5 45 235 540 728 9.14E-08 56.6 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P31396 CHOYP_DGRI_GH14972.1.1 m.64210 sp HR3_DROME 59.091 88 33 1 378 465 51 135 9.14E-28 122 HR3_DROME reviewed Probable nuclear hormone receptor HR3 (dHR3) (Nuclear receptor subfamily 1 group F member 4) Hr46 Hr3 NR1F4 CG11823 Drosophila melanogaster (Fruit fly) 487 "metamorphosis [GO:0007552]; mushroom body development [GO:0016319]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of development, heterochronic [GO:0040034]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000977; GO:0003707; GO:0004879; GO:0004887; GO:0005634; GO:0006351; GO:0007552; GO:0008270; GO:0016319; GO:0040034; GO:0045944 0 0 0 PF00104;PF00105; P47799 CHOYP_AAEL_AAEL004399.1.1 m.3003 sp FSHR_HORSE 38.627 743 361 13 30 767 16 668 9.14E-167 501 FSHR_HORSE reviewed Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor) FSHR Equus caballus (Horse) 694 activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G-protein coupled receptor signaling pathway [GO:0007189]; follicle-stimulating hormone signaling pathway [GO:0042699]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; primary ovarian follicle growth [GO:0001545]; regulation of osteoclast differentiation [GO:0045670]; regulation of protein kinase A signaling [GO:0010738] GO:0001545; GO:0004963; GO:0005887; GO:0007189; GO:0007190; GO:0008528; GO:0009755; GO:0010738; GO:0014068; GO:0042699; GO:0045670; GO:0070374 0 0 0 PF00001;PF12369;PF13306;PF13855;PF01462; Q08CG8 CHOYP_UBR3.1.1 m.43347 sp RNF44_DANRE 41.304 92 53 1 486 577 347 437 9.14E-19 92.8 RNF44_DANRE reviewed RING finger protein 44 rnf44 zgc:153103 Danio rerio (Zebrafish) (Brachydanio rerio) 448 "proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005654; GO:0005737; GO:0006355; GO:0008270; GO:0043161; GO:0061630 0 0 0 PF13639; Q174D3 CHOYP_RS9.12.13 m.65562 sp MED19_AEDAE 53.052 213 83 4 1 206 10 212 9.14E-61 193 MED19_AEDAE reviewed Mediator of RNA polymerase II transcription subunit 19 (Mediator complex subunit 19) MED19 AAEL006934 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 253 "transcription, DNA-templated [GO:0006351]" GO:0001104; GO:0006351; GO:0016592 0 0 0 PF10278; Q6DER2 CHOYP_RL36.7.8 m.38070 sp RL36_XENTR 65.625 96 31 1 16 111 1 94 9.14E-38 126 RL36_XENTR reviewed 60S ribosomal protein L36 rpl36 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 105 brain development [GO:0007420]; cytoplasmic translation [GO:0002181]; regulation of cell cycle [GO:0051726] GO:0002181; GO:0003735; GO:0007420; GO:0022625; GO:0051726 0 0 0 PF01158; Q8TBH0 CHOYP_ARRD3.1.2 m.16845 sp ARRD2_HUMAN 29.63 162 104 6 1 160 155 308 9.14E-16 78.6 ARRD2_HUMAN reviewed Arrestin domain-containing protein 2 ARRDC2 PP2703 Homo sapiens (Human) 407 signal transduction [GO:0007165] GO:0005886; GO:0007165; GO:0031410 0 0 0 PF02752;PF00339; Q99M80 CHOYP_PTPRT.28.45 m.52074 sp PTPRT_MOUSE 35.069 576 337 15 17 561 884 1453 9.14E-83 285 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9U3W6 CHOYP_LOC100370446.1.12 m.3001 sp MAB21_DROME 24.731 186 121 6 67 242 167 343 9.14E-07 54.3 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; P51910 CHOYP_LOC100371339.1.1 m.4513 sp APOD_MOUSE 36.979 192 111 7 1 189 1 185 9.15E-29 108 APOD_MOUSE reviewed Apolipoprotein D (Apo-D) (ApoD) Apod Mus musculus (Mouse) 189 aging [GO:0007568]; brain development [GO:0007420]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of lipoprotein lipid oxidation [GO:0060588]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of T cell migration [GO:2000405]; peripheral nervous system axon regeneration [GO:0014012]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to reactive oxygen species [GO:0000302]; tissue regeneration [GO:0042246] GO:0000302; GO:0005215; GO:0005615; GO:0005622; GO:0005783; GO:0006006; GO:0006629; GO:0007420; GO:0007568; GO:0010642; GO:0014012; GO:0015485; GO:0022626; GO:0030425; GO:0042246; GO:0042308; GO:0042493; GO:0043025; GO:0048471; GO:0048662; GO:0048678; GO:0051895; GO:0060588; GO:0070062; GO:0071638; GO:1900016; GO:2000098; GO:2000405 0 0 0 PF08212; Q08CI4 CHOYP_LOC100864008.1.1 m.52987 sp CCYL1_DANRE 59.239 368 115 10 1 362 1 339 9.15E-137 395 CCYL1_DANRE reviewed Cyclin-Y-like protein 1 ccnyl1 zgc:153047 Danio rerio (Zebrafish) (Brachydanio rerio) 339 regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079] GO:0000079 0 0 0 PF00134; Q60431 CHOYP_LOC100082745.1.1 m.65777 sp CASP3_MESAU 34.437 151 76 4 46 196 37 164 9.15E-16 80.5 CASP3_MESAU reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] CASP3 CPP32 Mesocricetus auratus (Golden hamster) 277 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q6DIB5 CHOYP_MEG10.90.91 m.65575 sp MEG10_MOUSE 38.961 154 74 7 170 311 127 272 9.15E-17 85.9 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6PBF0 CHOYP_RL8.5.10 m.35159 sp RL8_XENTR 65.772 149 49 1 1 147 1 149 9.15E-65 201 RL8_XENTR reviewed 60S ribosomal protein L8 rpl8 TTpA008p15.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 257 cytoplasmic translation [GO:0002181] GO:0002181; GO:0003735; GO:0019843; GO:0022625 0 0 0 PF00181;PF03947; Q8NEV4 CHOYP_LOC101171118.1.1 m.18112 sp MYO3A_HUMAN 43.612 227 126 1 12 236 924 1150 9.15E-51 194 MYO3A_HUMAN reviewed Myosin-IIIa (EC 2.7.11.1) MYO3A Homo sapiens (Human) 1616 protein autophosphorylation [GO:0046777]; response to stimulus [GO:0050896]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0000146; GO:0004672; GO:0004674; GO:0005516; GO:0005524; GO:0005737; GO:0007601; GO:0007605; GO:0016459; GO:0030175; GO:0030898; GO:0031941; GO:0043531; GO:0046777; GO:0050896; GO:0060002 0 0 0 PF00612;PF00063;PF00069; B3EWZ5 CHOYP_BRAFLDRAFT_227771.2.2 m.66356 sp MLRP1_ACRMI 32.471 773 410 30 72 795 760 1469 9.16E-95 329 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; D3ZAT9 CHOYP_LOC100377010.10.16 m.40964 sp FAXC_RAT 36.82 239 140 4 43 272 98 334 9.16E-49 169 FAXC_RAT reviewed Failed axon connections homolog Faxc Rattus norvegicus (Rat) 409 0 GO:0016021 0 0 0 PF17171;PF17172; O60879 CHOYP_ISCW_ISCW017338.1.1 m.2478 sp DIAP2_HUMAN 46.473 482 244 4 58 533 622 1095 9.16E-144 448 DIAP2_HUMAN reviewed Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) DIAPH2 DIA Homo sapiens (Human) 1101 actin filament organization [GO:0007015]; cytokinesis [GO:0000910]; female gamete generation [GO:0007292]; multicellular organism development [GO:0007275]; oogenesis [GO:0048477] GO:0000910; GO:0005102; GO:0005730; GO:0005739; GO:0005769; GO:0005794; GO:0005829; GO:0007015; GO:0007275; GO:0007292; GO:0043231; GO:0048477 0 0 0 PF06345;PF06367;PF06371;PF02181; Q460N5 CHOYP_BRAFLDRAFT_91321.2.10 m.20878 sp PAR14_HUMAN 22.662 278 201 6 53 324 565 834 9.16E-07 54.3 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q6AZV0 CHOYP_EEF1A.2.3 m.20691 sp DHSDB_XENLA 40.367 109 61 2 48 154 46 152 9.16E-22 88.2 DHSDB_XENLA reviewed "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial (CybS-B) (Succinate dehydrogenase complex subunit D-B) (Succinate-ubiquinone oxidoreductase cytochrome b small subunit B) (Succinate-ubiquinone reductase membrane anchor subunit B)" sdhd-b Xenopus laevis (African clawed frog) 152 tricarboxylic acid cycle [GO:0006099] GO:0005743; GO:0005749; GO:0006099; GO:0016021; GO:0020037; GO:0046872; GO:0048039 0 0 cd03496; 0 Q6DIB5 CHOYP_LOC101062986.2.3 m.61963 sp MEG10_MOUSE 38.346 133 73 7 366 497 532 656 9.16E-11 68.2 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q6PFY8 CHOYP_TRI33.6.8 m.61661 sp TRI45_MOUSE 28.079 203 126 5 5 195 127 321 9.16E-13 70.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q6R5N8 CHOYP_TOLL.1.2 m.24344 sp TLR13_MOUSE 26.058 591 361 23 168 711 422 983 9.16E-26 117 TLR13_MOUSE reviewed Toll-like receptor 13 Tlr13 Mus musculus (Mouse) 991 defense response to other organism [GO:0098542]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; regulation of MAPK cascade [GO:0043408]; response to virus [GO:0009615]; toll-like receptor 13 signaling pathway [GO:0034178] GO:0002755; GO:0003725; GO:0005737; GO:0005768; GO:0006954; GO:0009615; GO:0010008; GO:0016021; GO:0019843; GO:0034178; GO:0042803; GO:0043408; GO:0045087; GO:0098542 0 0 0 PF00560;PF12799;PF13855;PF01582; Q6UB98 CHOYP_ANR11.1.1 m.56842 sp ANR12_HUMAN 37.465 355 182 9 796 1124 1720 2060 9.16E-56 216 ANR12_HUMAN reviewed Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) ANKRD12 ANCO2 KIAA0874 Homo sapiens (Human) 2062 0 GO:0005654; GO:0005737 0 0 0 PF00023;PF12796; Q7SZS2 CHOYP_PTER.1.2 m.28985 sp PTER_XENLA 56.936 346 148 1 1 345 4 349 9.16E-147 421 PTER_XENLA reviewed Phosphotriesterase-related protein (EC 3.1.-.-) (Parathion hydrolase-related protein) pter Xenopus laevis (African clawed frog) 349 catabolic process [GO:0009056] GO:0008270; GO:0009056; GO:0016788 0 0 cd00530; PF02126; Q91V57 CHOYP_CHIN.1.1 m.48042 sp CHIN_MOUSE 48.796 457 226 5 25 481 10 458 9.16E-161 467 CHIN_MOUSE reviewed N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) Chn1 Arhgap2 Mus musculus (Mouse) 459 ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; motor neuron axon guidance [GO:0008045]; regulation of axonogenesis [GO:0050770]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0005096; GO:0005737; GO:0008045; GO:0035556; GO:0043087; GO:0046872; GO:0046875; GO:0048013; GO:0050770; GO:0051056 0 0 0 PF00130;PF00620;PF00017; Q92398 CHOYP_DICPUDRAFT_77168.2.2 m.61221 sp SPM1_SCHPO 30.332 211 114 7 389 573 18 221 9.16E-14 77.8 SPM1_SCHPO reviewed Mitogen-activated protein kinase spm1 (MAP kinase spm1) (EC 2.7.11.24) (MAP kinase pmk1) spm1 pmk1 SPBC119.08 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 422 cell cycle [GO:0007049]; MAPK cascade [GO:0000165]; MAPK cascade involved in cell wall organization or biogenesis [GO:0000196]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of calcium-mediated signaling involved in cellular response to salt stress [GO:1901196]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; regulation of cell shape [GO:0008360] GO:0000165; GO:0000196; GO:0004672; GO:0004707; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0007049; GO:0008360; GO:0010524; GO:0018107; GO:0032153; GO:0038067; GO:0044732; GO:0051091; GO:1901196 0 0 0 PF00069; A3KPQ7 CHOYP_LOC101171340.1.1 m.29474 sp TMEM2_DANRE 27.762 1059 621 34 53 1022 143 1146 9.17E-100 347 TMEM2_DANRE reviewed Transmembrane protein 2 tmem2 si:dkey-24k20.1 Danio rerio (Zebrafish) (Brachydanio rerio) 1378 atrioventricular valve formation [GO:0003190]; cell migration to the midline involved in heart development [GO:0003318]; heart looping [GO:0001947] GO:0001947; GO:0003190; GO:0003318; GO:0016021 0 0 0 PF10162; O50655 CHOYP_LOC100494344.1.3 m.46019 sp XERD_SELRU 27.469 324 195 12 16 321 23 324 9.17E-19 89 XERD_SELRU reviewed Integrase/recombinase xerD homolog xerD Selenomonas ruminantium 341 DNA integration [GO:0015074]; DNA recombination [GO:0006310]; establishment of integrated proviral latency [GO:0075713]; viral entry into host cell [GO:0046718] GO:0003677; GO:0006310; GO:0015074; GO:0046718; GO:0075713 0 0 0 PF00589; O70511 CHOYP_LOC100197555.1.7 m.23052 sp ANK3_RAT 29.083 447 279 3 109 518 55 500 9.17E-61 220 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P49796 CHOYP_PHUM_PHUM492360.1.1 m.12775 sp RGS3_HUMAN 34.979 243 153 2 57 297 135 374 9.17E-40 162 RGS3_HUMAN reviewed Regulator of G-protein signaling 3 (RGP3) (RGS3) RGS3 Homo sapiens (Human) 1198 inactivation of MAPK activity [GO:0000188]; regulation of G-protein coupled receptor protein signaling pathway [GO:0008277] GO:0000188; GO:0005096; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0008277 0 0 0 PF00168;PF00595;PF00615; P62752 CHOYP_RL23A.2.6 m.16494 sp RL23A_RAT 80.952 126 24 0 49 174 31 156 9.17E-67 203 RL23A_RAT reviewed 60S ribosomal protein L23a Rpl23a Rattus norvegicus (Rat) 156 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0000166; GO:0003735; GO:0005634; GO:0006412; GO:0022625; GO:0070180 0 0 0 PF00276;PF03939; P62840 CHOYP_UB2D2.1.1 m.56387 sp UB2D2_XENLA 50.676 148 71 1 1 148 1 146 9.17E-54 169 UB2D2_XENLA reviewed Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein 4) (xUBC4) (Ubiquitin carrier protein D2) (Ubiquitin-protein ligase D2) ube2d2 ubc4 ube2d3.1 Xenopus laevis (African clawed frog) 147 protein ubiquitination [GO:0016567] GO:0005524; GO:0016567; GO:0016740 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q0V9J5 CHOYP_LOC100705082.1.1 m.45787 sp EIF1A_XENTR 52.903 155 59 2 1 141 1 155 9.17E-49 158 EIF1A_XENTR reviewed Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) eif1ad Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 179 0 GO:0003743; GO:0005634 0 0 0 PF01176; Q1ED21 CHOYP_NR2CA.1.1 m.40388 sp NR2CA_DANRE 47.445 137 72 0 21 157 1 137 9.17E-44 144 NR2CA_DANRE reviewed Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein homolog) nr2c2ap tra16 ch211-125m10.4 zgc:136330 Danio rerio (Zebrafish) (Brachydanio rerio) 141 0 GO:0005634 0 0 0 PF07738; Q55E58 CHOYP_BRAFLDRAFT_86694.1.3 m.22587 sp PATS1_DICDI 23.649 296 177 10 398 681 1764 2022 9.17E-13 77 PATS1_DICDI reviewed Probable serine/threonine-protein kinase pats1 (EC 2.7.11.1) (Protein associated with the transduction of signal 1) pats1 DDB_G0269250 Dictyostelium discoideum (Slime mold) 3184 mitotic cytokinesis [GO:0000281]; protein dephosphorylation [GO:0006470]; small GTPase mediated signal transduction [GO:0007264]; social behavior [GO:0035176] GO:0000281; GO:0004674; GO:0004721; GO:0005524; GO:0005525; GO:0006470; GO:0007264; GO:0035176; GO:0042641 0 0 0 PF16095;PF06602;PF07714;PF08477; Q5THR3 CHOYP_BRAFLDRAFT_117976.2.3 m.49156 sp EFCB6_HUMAN 21.031 718 470 16 251 924 832 1496 9.17E-33 141 EFCB6_HUMAN reviewed EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) EFCAB6 DJBP KIAA1672 Homo sapiens (Human) 1501 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q8BKT8 CHOYP_BRAFLDRAFT_131050.1.1 m.18133 sp HAUS7_MOUSE 23.164 354 238 10 25 368 32 361 9.17E-17 84.3 HAUS7_MOUSE reviewed HAUS augmin-like complex subunit 7 (26S proteasome-associated UCH37-interacting protein 1) (UCHL5-interacting protein) Haus7 Uchl5ip Uip1 Mus musculus (Mouse) 364 cell division [GO:0051301]; centrosome organization [GO:0051297]; mitotic nuclear division [GO:0007067]; spindle assembly [GO:0051225] GO:0005730; GO:0005737; GO:0005813; GO:0005819; GO:0005874; GO:0005886; GO:0007067; GO:0031996; GO:0051225; GO:0051297; GO:0051301; GO:0070652 0 0 0 0 Q96RW7 CHOYP_BRAFLDRAFT_88566.2.11 m.4150 sp HMCN1_HUMAN 45.115 348 178 4 155 501 4534 4869 9.17E-85 293 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9CZJ2 CHOYP_HS12B.14.14 m.66070 sp HS12B_MOUSE 33.912 634 345 16 13 583 61 683 9.17E-107 338 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9HC62 CHOYP_TTPAL.1.2 m.2243 sp SENP2_HUMAN 22.778 180 120 7 236 399 411 587 9.17E-06 51.6 SENP2_HUMAN reviewed Sentrin-specific protease 2 (EC 3.4.22.68) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2) SENP2 KIAA1331 Homo sapiens (Human) 589 "dorsal/ventral axis specification [GO:0009950]; fat cell differentiation [GO:0045444]; heart development [GO:0007507]; labyrinthine layer development [GO:0060711]; mRNA transport [GO:0051028]; negative regulation of chromatin binding [GO:0035562]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of protein binding [GO:0032091]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein destabilization [GO:0031648]; protein desumoylation [GO:0016926]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of DNA endoreduplication [GO:0032875]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; regulation of Wnt signaling pathway [GO:0030111]; spongiotrophoblast layer development [GO:0060712]; trophoblast giant cell differentiation [GO:0060707]; Wnt signaling pathway [GO:0016055]" GO:0001934; GO:0004175; GO:0005643; GO:0005654; GO:0007507; GO:0009950; GO:0015031; GO:0016055; GO:0016605; GO:0016925; GO:0016926; GO:0016929; GO:0030111; GO:0031397; GO:0031398; GO:0031410; GO:0031648; GO:0031965; GO:0032091; GO:0032875; GO:0035562; GO:0043518; GO:0045444; GO:0045944; GO:0051028; GO:0060707; GO:0060711; GO:0060712; GO:0070139; GO:2000045 0 0 0 PF02902; Q9NPC3 CHOYP_BRAFLDRAFT_237296.1.1 m.48335 sp CIP1_HUMAN 54.645 183 82 1 15 196 5 187 9.17E-70 220 CIP1_HUMAN reviewed E3 ubiquitin-protein ligase CCNB1IP1 (EC 6.3.2.-) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) CCNB1IP1 C14orf18 HEI10 Homo sapiens (Human) 277 blastocyst formation [GO:0001825]; chiasma assembly [GO:0051026]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286] GO:0000795; GO:0001825; GO:0007131; GO:0007286; GO:0008270; GO:0016567; GO:0016874; GO:0051026; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF14634; B3EWZ5 CHOYP_NEMVEDRAFT_V1G198667.15.15 m.63895 sp MLRP1_ACRMI 30.303 165 104 6 121 278 257 417 9.18E-15 78.2 MLRP1_ACRMI reviewed MAM and LDL-receptor class A domain-containing protein 1 (Skeletal organic matrix MAM and LDL-receptor 1) (SOM MAM and LDL-receptor 1) (Fragment) 0 Acropora millepora (Staghorn coral) 5145 0 GO:0005576; GO:0016020 0 0 cd06263;cd00111; PF00057;PF00629;PF00088; O01727 CHOYP_RS6.5.12 m.23146 sp RS6_BRAFL 71.66 247 66 1 1 247 1 243 9.18E-128 364 RS6_BRAFL reviewed 40S ribosomal protein S6 RPS6 Branchiostoma floridae (Florida lancelet) (Amphioxus) 244 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01092; O07552 CHOYP_NEMVEDRAFT_V1G236658.5.6 m.34525 sp NHAX_BACSU 30.12 166 94 4 3 149 4 166 9.18E-15 70.9 NHAX_BACSU reviewed Stress response protein NhaX nhaX yheK BSU09690 Bacillus subtilis (strain 168) 166 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; O35136 CHOYP_LOC100313653.1.1 m.61187 sp NCAM2_MOUSE 23.014 365 224 19 111 455 180 507 9.18E-08 59.3 NCAM2_MOUSE reviewed Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) (Neural cell adhesion molecule RB-8) (R4B12) Ncam2 Ocam Rncam Mus musculus (Mouse) 837 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030424; GO:0031225 0 0 0 PF00041;PF07679; P02746 CHOYP_C1QRF.3.3 m.50491 sp C1QB_HUMAN 34.483 116 69 4 107 221 136 245 9.18E-10 60.5 C1QB_HUMAN reviewed Complement C1q subcomponent subunit B C1QB Homo sapiens (Human) 253 "complement activation [GO:0006956]; complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; inner ear development [GO:0048839]" GO:0004252; GO:0005576; GO:0005581; GO:0005602; GO:0006956; GO:0006958; GO:0045087; GO:0048839; GO:0070062; GO:0072562 0 0 0 PF00386;PF01391; P12394 CHOYP_LOC579395.1.2 m.28133 sp CP17A_CHICK 28.607 402 249 9 6 384 116 502 9.18E-41 153 CP17A_CHICK reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Gallus gallus (Chicken) 508 hormone biosynthetic process [GO:0042446]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0008202; GO:0016020; GO:0020037; GO:0042446; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q07076 CHOYP_ANXA7.3.4 m.48325 sp ANXA7_MOUSE 52.417 393 147 8 134 516 101 463 9.18E-123 370 ANXA7_MOUSE reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) Anxa7 Anx7 Mus musculus (Mouse) 463 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; membrane fusion [GO:0061025]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to calcium ion [GO:0051592]; response to organic cyclic compound [GO:0014070]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005178; GO:0005509; GO:0005544; GO:0005634; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0014070; GO:0016020; GO:0030855; GO:0031982; GO:0035176; GO:0042584; GO:0044822; GO:0048306; GO:0051592; GO:0061025; GO:0070062 0 0 0 PF00191; Q2EMV9 CHOYP_LOC100367414.3.7 m.37940 sp PAR14_MOUSE 23.454 388 235 9 59 435 20 356 9.18E-14 77.4 PAR14_MOUSE reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (Collaborator of STAT6) (CoaSt6) Parp14 Kiaa1268 Mus musculus (Mouse) 1817 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q2NNR5 CHOYP_CLTR1.2.2 m.34083 sp CLTR1_CAVPO 22.917 336 233 6 17 344 5 322 9.18E-13 72.4 CLTR1_CAVPO reviewed Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) CYSLTR1 Cavia porcellus (Guinea pig) 340 calcium ion transport [GO:0006816]; cell surface receptor signaling pathway [GO:0007166]; chemotaxis [GO:0006935] GO:0004974; GO:0005887; GO:0006816; GO:0006935; GO:0007166 0 0 0 PF00001; Q2VWP7 CHOYP_PRTG.3.3 m.43146 sp PRTG_HUMAN 30.204 980 603 33 37 985 45 974 9.18E-109 373 PRTG_HUMAN reviewed Protogenin (Protein Shen-Dan) PRTG Homo sapiens (Human) 1150 multicellular organism development [GO:0007275] GO:0005615; GO:0007275; GO:0016021 0 0 0 PF00041;PF07679; Q6AXU6 CHOYP_MPET_1013.2.2 m.58810 sp HN1_RAT 48.148 54 27 1 1 53 1 54 9.18E-06 46.6 HN1_RAT reviewed "Hematological and neurological expressed 1 protein [Cleaved into: Hematological and neurological expressed 1 protein, N-terminally processed]" Hn1 Rattus norvegicus (Rat) 149 0 GO:0005730; GO:0031965 0 0 0 PF17054; Q86XX4 CHOYP_CRIM2.1.1 m.20338 sp FRAS1_HUMAN 27.519 258 167 7 518 764 99 347 9.18E-20 99 FRAS1_HUMAN reviewed Extracellular matrix protein FRAS1 FRAS1 KIAA1500 Homo sapiens (Human) 4008 cell communication [GO:0007154]; embryonic limb morphogenesis [GO:0030326]; metanephros morphogenesis [GO:0003338]; morphogenesis of an epithelium [GO:0002009]; palate development [GO:0060021]; protein transport [GO:0015031]; skin development [GO:0043588] GO:0002009; GO:0003338; GO:0005886; GO:0007154; GO:0015031; GO:0016021; GO:0030326; GO:0043588; GO:0046872; GO:0060021; GO:0061618 0 0 0 PF03160;PF00093; Q8MQI6 CHOYP_ISCW_ISCW008316.1.3 m.11997 sp ELOF1_DROME 79.268 82 17 0 25 106 1 82 9.18E-46 145 ELOF1_DROME reviewed Transcription elongation factor 1 homolog CG40228 Drosophila melanogaster (Fruit fly) 82 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF05129; Q90252 CHOYP_MTR.1.1 m.25506 sp MTR_RHIMB 33.22 295 167 10 53 336 61 336 9.18E-30 120 MTR_RHIMB reviewed Mesotocin receptor (MTR) 0 Rhinella marina (Cane toad) (Bufo marinus) 389 0 GO:0004990; GO:0005000; GO:0005886; GO:0016021 0 0 0 PF00001; Q9NXK8 CHOYP_NEMVEDRAFT_V1G165143.1.1 m.18443 sp FXL12_HUMAN 32.463 268 167 6 28 292 1 257 9.18E-35 133 FXL12_HUMAN reviewed F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) FBXL12 FBL12 Homo sapiens (Human) 326 protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000151; GO:0005737; GO:0006511; GO:0016567 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12937; Q9QYS1 CHOYP_WNT16.1.1 m.43727 sp WNT16_MOUSE 52.778 360 160 3 11 361 6 364 9.18E-139 401 WNT16_MOUSE reviewed Protein Wnt-16 Wnt16 Mus musculus (Mouse) 364 bone remodeling [GO:0046849]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell fate commitment [GO:0045165]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of cell death [GO:0060548]; neuron differentiation [GO:0030182]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; replicative senescence [GO:0090399]; Wnt signaling pathway [GO:0016055] GO:0005109; GO:0005578; GO:0005615; GO:0005737; GO:0010628; GO:0014068; GO:0016055; GO:0030182; GO:0030216; GO:0043616; GO:0045165; GO:0046330; GO:0046849; GO:0060317; GO:0060548; GO:0090399; GO:0090403 0 0 0 PF00110; Q9U3W6 CHOYP_BRAFLDRAFT_101704.1.1 m.21741 sp MAB21_DROME 23.353 167 116 3 52 212 183 343 9.18E-07 53.9 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; Q9VXX8 CHOYP_RL371.1.2 m.18873 sp RL371_DROME 75.61 82 20 0 1 82 1 82 9.18E-40 130 RL371_DROME reviewed Probable 60S ribosomal protein L37-A RpL37a CG9091 Drosophila melanogaster (Fruit fly) 93 translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0019843; GO:0022625; GO:0046872 0 0 0 PF01907; A4IGK3 CHOYP_CRBL2.1.7 m.233 sp CRBL2_XENTR 65.753 73 25 0 31 103 15 87 9.19E-26 97.4 CRBL2_XENTR reviewed cAMP-responsive element-binding protein-like 2 crebl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 118 "cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0030154; GO:0043565; GO:0045600; GO:0045893; GO:0046326; GO:0046889 0 0 0 PF07716; C1C524 CHOYP_CISD2.1.1 m.26823 sp CISD2_LITCT 60.606 132 50 2 11 140 3 134 9.19E-54 168 CISD2_LITCT reviewed CDGSH iron-sulfur domain-containing protein 2 cisd2 Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) 135 mitophagy [GO:0000422]; multicellular organism aging [GO:0010259]; regulation of autophagy [GO:0010506] GO:0000422; GO:0005741; GO:0005789; GO:0010259; GO:0010506; GO:0016021; GO:0042803; GO:0046872; GO:0051537 0 0 0 PF10660;PF09360; D3YXG0 CHOYP_HMCN1.10.44 m.27606 sp HMCN1_MOUSE 46.528 144 77 0 1 144 4669 4812 9.19E-43 157 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; O43614 CHOYP_LOC762961.3.5 m.46330 sp OX2R_HUMAN 24.599 374 238 12 51 405 35 383 9.19E-25 108 OX2R_HUMAN reviewed Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) HCRTR2 Homo sapiens (Human) 444 "cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; circadian sleep/wake cycle process [GO:0022410]; feeding behavior [GO:0007631]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; regulation of circadian sleep/wake cycle, wakefulness [GO:0010840]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to peptide [GO:1901652]" GO:0005886; GO:0005887; GO:0007200; GO:0007218; GO:0007268; GO:0007631; GO:0008188; GO:0010840; GO:0016499; GO:0017046; GO:0022410; GO:0032870; GO:0042277; GO:0045187; GO:0051480; GO:1901652 0 0 0 PF00001;PF03827; P20273 CHOYP_DPER_GL17448.1.1 m.54836 sp CD22_HUMAN 24.177 699 446 31 56 709 25 684 9.19E-25 115 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; Q08DB5 CHOYP_LOC100372966.1.1 m.18755 sp STX5_BOVIN 65.541 296 80 9 37 322 55 338 9.19E-122 357 STX5_BOVIN reviewed Syntaxin-5 STX5 Bos taurus (Bovine) 355 early endosome to Golgi transport [GO:0034498]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; regulation of Golgi organization [GO:1903358]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000139; GO:0000149; GO:0005484; GO:0005654; GO:0005829; GO:0006886; GO:0006888; GO:0006906; GO:0016021; GO:0031201; GO:0031982; GO:0033116; GO:0034498; GO:0045732; GO:0048278; GO:0090166; GO:1903358 0 0 0 PF05739;PF11416; Q460N3 CHOYP_PARP15.1.3 m.21177 sp PAR15_HUMAN 24.528 477 258 16 26 501 301 676 9.19E-22 102 PAR15_HUMAN reviewed Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3) PARP15 BAL3 Homo sapiens (Human) 678 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF01661;PF00644; Q5W041 CHOYP_LOC100370900.1.1 m.20012 sp ARMC3_HUMAN 45.688 661 306 3 316 976 1 608 9.19E-177 546 ARMC3_HUMAN reviewed Armadillo repeat-containing protein 3 (Beta-catenin-like protein) (Cancer/testis antigen 81) (CT81) (KU-CT-1) ARMC3 Homo sapiens (Human) 872 0 GO:0005634; GO:0005737; GO:0070062 0 0 0 PF00514; Q86YA3 CHOYP_LOC101359921.1.2 m.6986 sp ZGRF1_HUMAN 39.063 128 67 3 42 161 1 125 9.19E-19 87.4 ZGRF1_HUMAN reviewed Protein ZGRF1 (GRF-type zinc finger domain-containing protein 1) ZGRF1 C4orf21 Homo sapiens (Human) 2104 0 GO:0008270; GO:0016021 0 0 0 PF10382;PF06839; Q8R0T2 CHOYP_ZNF25.2.2 m.60131 sp ZN768_MOUSE 34.211 228 137 4 340 563 320 538 9.19E-36 144 ZN768_MOUSE reviewed Zinc finger protein 768 Znf768 Zfp768 Mus musculus (Mouse) 568 "regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0003677; GO:0005665; GO:0006355; GO:0006366; GO:0044822; GO:0046872 0 0 0 PF05001;PF00096; P04113 CHOYP_MLRB.1.1 m.41085 sp MLRA_MIZYE 77.863 131 29 0 1 131 31 161 9.20E-68 204 MLRA_MIZYE reviewed "Myosin regulatory light chain A, smooth adductor muscle" 0 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis) 161 0 GO:0005509; GO:0016459 0 0 0 PF13405; P28572 CHOYP_LOC100179103.1.1 m.51600 sp SC6A9_RAT 39.024 328 131 5 100 408 22 299 9.20E-67 226 SC6A9_RAT reviewed Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) Slc6a9 Rattus norvegicus (Rat) 638 "glycine import [GO:0036233]; glycine secretion, neurotransmission [GO:0061537]; synaptic transmission, glycinergic [GO:0060012]" GO:0005328; GO:0005887; GO:0015187; GO:0015375; GO:0036233; GO:0060012; GO:0061537; GO:0098793 0 0 0 PF00209; P33316 CHOYP_LOC100183847.2.2 m.17649 sp DUT_HUMAN 70 100 30 0 14 113 100 199 9.20E-45 149 DUT_HUMAN reviewed "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)" DUT Homo sapiens (Human) 252 DNA replication [GO:0006260]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; nucleobase-containing compound metabolic process [GO:0006139]; pyrimidine nucleoside biosynthetic process [GO:0046134] GO:0000287; GO:0004170; GO:0005634; GO:0005654; GO:0005739; GO:0006139; GO:0006226; GO:0006260; GO:0044822; GO:0046081; GO:0046134; GO:0070062 PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. 0 cd07557; PF00692; P45842 CHOYP_ISCW_ISCW001285.2.2 m.15985 sp RL34_AEDAL 70.588 68 20 0 1 68 1 68 9.20E-26 96.7 RL34_AEDAL reviewed 60S ribosomal protein L34 (L31) RpL34 RpL31 Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01199; Q03161 CHOYP_BRAFLDRAFT_113534.1.1 m.10828 sp YMY9_YEAST 35.766 274 161 7 4 266 8 277 9.20E-52 174 YMY9_YEAST reviewed Glucose-6-phosphate 1-epimerase (EC 5.1.3.15) (D-hexose-6-phosphate mutarotase) YMR099C YM6543.06C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 297 cellular carbohydrate metabolic process [GO:0044262] GO:0030246; GO:0044262; GO:0047938 0 0 cd09020; PF01263; Q502K3 CHOYP_NEMVEDRAFT_V1G199564.3.6 m.52999 sp ANR52_DANRE 38.621 145 85 3 7 149 210 352 9.20E-18 92.4 ANR52_DANRE reviewed Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C (PP6-ARS-C) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C) ankrd52 zgc:112069 Danio rerio (Zebrafish) (Brachydanio rerio) 1071 0 0 0 0 0 PF00023;PF12796; Q80XI3 CHOYP_BRAFLDRAFT_277494.1.3 m.54114 sp IF4G3_MOUSE 41.344 491 258 7 37 502 1094 1579 9.20E-116 376 IF4G3_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Eif4g3 Mus musculus (Mouse) 1579 positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283] GO:0001934; GO:0003743; GO:0007283; GO:0044822; GO:0045727; GO:0060903 0 0 0 PF02847;PF02854;PF02020; Q8CI17 CHOYP_NEMVEDRAFT_V1G206032.1.1 m.58857 sp MB213_MOUSE 26.506 166 107 5 577 735 262 419 9.20E-09 62.4 MB213_MOUSE reviewed Protein mab-21-like 3 Mab21L3 Mus musculus (Mouse) 429 0 0 0 0 0 PF03281; Q96Q06 CHOYP_Y7557.1.3 m.21382 sp PLIN4_HUMAN 21.053 209 153 4 42 249 427 624 9.20E-06 52.4 PLIN4_HUMAN reviewed Perilipin-4 (Adipocyte protein S3-12) PLIN4 KIAA1881 Homo sapiens (Human) 1357 0 GO:0005737; GO:0005811; GO:0005886; GO:0043231 0 0 0 PF03036; Q9HCF6 CHOYP_TRPM2.3.12 m.33758 sp TRPM3_HUMAN 32.057 209 124 4 1 204 997 1192 9.20E-28 114 TRPM3_HUMAN reviewed Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) TRPM3 KIAA1616 LTRPC3 Homo sapiens (Human) 1732 calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951] GO:0005227; GO:0005261; GO:0005262; GO:0005886; GO:0006812; GO:0016021; GO:0016048; GO:0050951; GO:0051262; GO:0070588 0 0 0 PF00520;PF16519; Q9P215 CHOYP_LOC101169293.2.4 m.16893 sp POGK_HUMAN 39.063 128 74 3 114 238 197 323 9.20E-18 90.5 POGK_HUMAN reviewed Pogo transposable element with KRAB domain POGK KIAA1513 LST003 SLTP003 Homo sapiens (Human) 609 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0003677; GO:0005634; GO:0006355; GO:0007275 0 0 cd07765; PF09607;PF03184;PF03221;PF01352; O96006 CHOYP_LOC100637265.1.1 m.1027 sp ZBED1_HUMAN 32.09 134 85 2 4 137 308 435 9.21E-13 67.4 ZBED1_HUMAN reviewed Zinc finger BED domain-containing protein 1 (Putative Ac-like transposable element) (dREF homolog) ZBED1 ALTE DREF KIAA0785 TRAMP Homo sapiens (Human) 694 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0000228; GO:0000977; GO:0003700; GO:0004803; GO:0005634; GO:0005737; GO:0006357; GO:0015629; GO:0046872 0 0 0 PF05699;PF02892; Q04202 CHOYP_CRE_23859.1.2 m.3094 sp TCB2_CAEBR 32.215 149 101 0 8 156 125 273 9.21E-24 96.7 TCB2_CAEBR reviewed Transposable element Tcb2 transposase 0 Caenorhabditis briggsae 273 "DNA integration [GO:0015074]; transposition, DNA-mediated [GO:0006313]" GO:0003677; GO:0005634; GO:0006313; GO:0015074 0 0 0 PF01498; Q07837 CHOYP_BRAFLDRAFT_265208.7.7 m.62512 sp SLC31_HUMAN 31.788 151 93 8 12 156 504 650 9.21E-11 62.4 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q07837 CHOYP_SLC31.1.5 m.13054 sp SLC31_HUMAN 31.788 151 93 8 12 156 504 650 9.21E-11 62.4 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q07837 CHOYP_SLC31.2.5 m.15006 sp SLC31_HUMAN 31.788 151 93 8 12 156 504 650 9.21E-11 62.4 SLC31_HUMAN reviewed "Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)" SLC3A1 RBAT Homo sapiens (Human) 685 amino acid transport [GO:0006865]; basic amino acid transport [GO:0015802]; carbohydrate metabolic process [GO:0005975]; cellular amino acid metabolic process [GO:0006520]; L-cystine transport [GO:0015811] GO:0003824; GO:0005743; GO:0005774; GO:0005886; GO:0005887; GO:0005975; GO:0006520; GO:0006865; GO:0015171; GO:0015174; GO:0015184; GO:0015802; GO:0015811; GO:0016020; GO:0031526; GO:0070062 0 0 0 PF00128; Q13263 CHOYP_LOC100370588.3.19 m.9345 sp TIF1B_HUMAN 24.752 202 115 7 4 170 142 341 9.21E-06 49.7 TIF1B_HUMAN reviewed Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28) TRIM28 KAP1 RNF96 TIF1B Homo sapiens (Human) 835 "convergent extension involved in axis elongation [GO:0060028]; covalent chromatin modification [GO:0016569]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]" GO:0001105; GO:0001837; GO:0003677; GO:0003682; GO:0003700; GO:0003714; GO:0004672; GO:0004842; GO:0005634; GO:0005654; GO:0005719; GO:0005720; GO:0006281; GO:0006367; GO:0007265; GO:0007566; GO:0008270; GO:0016569; GO:0016874; GO:0016925; GO:0031625; GO:0035851; GO:0042993; GO:0043045; GO:0043565; GO:0044822; GO:0045087; GO:0045739; GO:0045892; GO:0045893; GO:0046777; GO:0051259; GO:0060028; GO:0060669; GO:0070087; GO:0090309; GO:0090575; GO:1901536; GO:1902187; GO:1990841; GO:2000653 PATHWAY: Protein modification; protein sumoylation. 0 0 PF00628;PF00643;PF14634; Q14249 CHOYP_DVIR_GJ19936.1.1 m.30318 sp NUCG_HUMAN 52.282 241 109 3 71 308 40 277 9.21E-87 265 NUCG_HUMAN reviewed "Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)" ENDOG Homo sapiens (Human) 297 aging [GO:0007568]; apoptotic DNA fragmentation [GO:0006309]; cellular response to calcium ion [GO:0071277]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; DNA recombination [GO:0006310]; in utero embryonic development [GO:0001701]; neuron death in response to oxidative stress [GO:0036475]; positive regulation of apoptotic DNA fragmentation [GO:1902512]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; response to antibiotic [GO:0046677]; response to estradiol [GO:0032355]; response to mechanical stimulus [GO:0009612]; response to tumor necrosis factor [GO:0034612] GO:0001701; GO:0003676; GO:0004519; GO:0004536; GO:0005634; GO:0005739; GO:0005829; GO:0006309; GO:0006310; GO:0007568; GO:0009612; GO:0032355; GO:0034612; GO:0036475; GO:0043204; GO:0046677; GO:0046872; GO:0071277; GO:0071333; GO:0071456; GO:1901300; GO:1902512 0 0 0 PF01223; Q3ZBB6 CHOYP_AP4S1.1.1 m.55958 sp AP4S1_BOVIN 41.007 139 79 2 1 136 1 139 9.21E-36 123 AP4S1_BOVIN reviewed AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin) AP4S1 Bos taurus (Bovine) 144 0 GO:0005794; GO:0005905; GO:0008565 0 0 0 PF01217; Q4KL91 CHOYP_LOC100892108.1.1 m.52001 sp S36A4_XENLA 24.214 318 188 7 247 561 228 495 9.21E-21 99.4 S36A4_XENLA reviewed Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4) slc36a4 pat4 Xenopus laevis (African clawed frog) 522 amino acid transport [GO:0006865] GO:0006865; GO:0015293; GO:0016021 0 0 0 PF01490; Q4UMH6 CHOYP_ANR28.3.3 m.34255 sp Y381_RICFE 21.245 273 187 7 32 300 676 924 9.21E-12 70.1 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q5R5M4 CHOYP_MOT6.1.1 m.52480 sp MOT9_PONAB 30.178 169 118 0 9 177 14 182 9.21E-20 92.4 MOT9_PONAB reviewed Monocarboxylate transporter 9 (MCT 9) (Solute carrier family 16 member 9) SLC16A9 MCT9 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 509 0 GO:0005886; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q5RAS8 CHOYP_LOC100374662.2.6 m.17015 sp TM199_PONAB 37.5 152 84 4 41 187 54 199 9.21E-28 106 TM199_PONAB reviewed Transmembrane protein 199 TMEM199 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 208 0 GO:0016021; GO:0030663; GO:0033116 0 0 0 PF11712; Q6MG64 CHOYP_BRAFLDRAFT_63397.7.8 m.61628 sp VWA7_RAT 23.864 616 379 24 80 670 90 640 9.21E-30 131 VWA7_RAT reviewed von Willebrand factor A domain-containing protein 7 (Protein G7c) Vwa7 G7c Rattus norvegicus (Rat) 892 0 GO:0005576 0 0 0 0 Q6YHK3 CHOYP_LOC100375357.1.1 m.46425 sp CD109_HUMAN 35.814 215 126 5 19 224 28 239 9.21E-36 137 CD109_HUMAN reviewed CD109 antigen (150 kDa TGF-beta-1-binding protein) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7) (Platelet-specific Gov antigen) (p180) (r150) (CD antigen CD109) CD109 CPAMD7 Homo sapiens (Human) 1445 hair follicle development [GO:0001942]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of wound healing [GO:0061045]; osteoclast fusion [GO:0072675]; regulation of keratinocyte differentiation [GO:0045616] GO:0001933; GO:0001942; GO:0004867; GO:0005615; GO:0005886; GO:0009986; GO:0010839; GO:0030512; GO:0031225; GO:0045616; GO:0050431; GO:0061045; GO:0072675 0 0 0 PF00207;PF07678;PF01835;PF07703;PF07677;PF10569; Q9DCR2 CHOYP_LOC663336.1.1 m.31512 sp AP3S1_MOUSE 86.986 146 19 0 13 158 7 152 9.21E-92 268 AP3S1_MOUSE reviewed AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a) Ap3s1 Mus musculus (Mouse) 193 anterograde axonal transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192] GO:0005802; GO:0006886; GO:0008089; GO:0008565; GO:0016020; GO:0016192; GO:0030123; GO:0030659; GO:0043231; GO:0048490; GO:1904115 0 0 0 PF01217; Q9NZJ4 CHOYP_BRAFLDRAFT_118535.1.8 m.4096 sp SACS_HUMAN 25 304 171 9 45 323 4302 4573 9.21E-17 85.1 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9UBH6 CHOYP_LOC100142189.1.1 m.21596 sp XPR1_HUMAN 67.361 144 46 1 4 146 509 652 9.21E-66 216 XPR1_HUMAN reviewed Xenotropic and polytropic retrovirus receptor 1 (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor) XPR1 SYG1 XR Homo sapiens (Human) 696 cellular phosphate ion homeostasis [GO:0030643]; G-protein coupled receptor signaling pathway [GO:0007186]; phosphate ion transmembrane transport [GO:0035435]; response to virus [GO:0009615] GO:0000822; GO:0001618; GO:0004872; GO:0004888; GO:0004930; GO:0005794; GO:0007186; GO:0009615; GO:0015114; GO:0015562; GO:0016021; GO:0030643; GO:0031226; GO:0035435 0 0 0 PF03124;PF03105; B3EWY9 CHOYP_BRAFLDRAFT_92365.1.3 m.48019 sp MLP_ACRMI 26.458 703 426 24 274 923 388 1052 9.22E-52 202 MLP_ACRMI reviewed Mucin-like protein (Fragment) 0 Acropora millepora (Staghorn coral) 1594 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0007160; GO:0016021 0 0 0 PF12662;PF06119;PF00090;PF00094; Q5ZIQ3 CHOYP_LOC100378252.1.1 m.16877 sp HNRPK_CHICK 56.621 219 90 3 8 226 18 231 9.22E-71 235 HNRPK_CHICK reviewed Heterogeneous nuclear ribonucleoprotein K (hnRNP K) HNRNPK HNRPK RCJMB04_24e23 Gallus gallus (Chicken) 427 "mRNA processing [GO:0006397]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003723; GO:0005654; GO:0005681; GO:0005737; GO:0006351; GO:0006357; GO:0006397; GO:0008380 0 0 0 PF00013;PF08067; Q8C8H8 CHOYP_KY.3.5 m.11421 sp KY_MOUSE 35.294 153 81 6 903 1045 228 372 9.22E-17 89 KY_MOUSE reviewed Kyphoscoliosis peptidase (EC 3.4.-.-) Ky Mus musculus (Mouse) 661 muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528] GO:0005856; GO:0007517; GO:0007528; GO:0008233; GO:0030018 0 0 0 PF01841; Q92193 CHOYP_LOC101470738.2.2 m.26124 sp ACT_CRAVI 95.918 98 4 0 1 98 93 190 9.22E-64 196 ACT_CRAVI reviewed Actin (Fragment) 0 Crassostrea virginica (Eastern oyster) 266 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9UMZ3 CHOYP_LOC100540260.1.1 m.38609 sp PTPRQ_HUMAN 34.978 223 119 10 173 379 1912 2124 9.22E-16 82.8 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; O75179 CHOYP_LOC753709.39.44 m.63853 sp ANR17_HUMAN 35.907 259 156 7 1 251 447 703 9.23E-33 129 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; O75382 CHOYP_LOC101241499.1.4 m.389 sp TRIM3_HUMAN 25.856 263 140 13 135 366 469 707 9.23E-10 63.9 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P0C691 CHOYP_LOC100494686.1.1 m.36734 sp DPOL_DHBV3 28.834 163 112 3 112 273 446 605 9.23E-08 58.5 DPOL_DHBV3 reviewed Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC 2.7.7.49); Ribonuclease H (EC 3.1.26.4)] P Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV) 786 DNA replication [GO:0006260] GO:0003677; GO:0003887; GO:0003964; GO:0004523; GO:0006260; GO:0046872 0 0 0 PF00336;PF00242;PF00078; P41777 CHOYP_LOC100880757.1.2 m.19188 sp NOLC1_RAT 56.818 88 37 1 362 448 617 704 9.23E-24 107 NOLC1_RAT reviewed Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) Nolc1 Rattus norvegicus (Rat) 704 "box H/ACA snoRNA metabolic process [GO:0033979]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of protein import into nucleus [GO:0042306]; response to osmotic stress [GO:0006970]" GO:0003700; GO:0005524; GO:0005525; GO:0005654; GO:0005730; GO:0005737; GO:0006970; GO:0008134; GO:0008139; GO:0008284; GO:0019904; GO:0033979; GO:0034512; GO:0034513; GO:0042306; GO:0045893 0 0 0 PF05022; Q04652 CHOYP_LOC100900434.1.1 m.15530 sp KELC_DROME 42.478 113 62 2 31 141 149 260 9.23E-23 98.2 KELC_DROME reviewed Ring canal kelch protein [Cleaved into: Kelch short protein] kel CG7210 Drosophila melanogaster (Fruit fly) 1477 actin cytoskeleton organization [GO:0030036]; cellularization [GO:0007349]; female germline ring canal formation [GO:0007301]; karyosome formation [GO:0030717]; oogenesis [GO:0048477]; ovarian follicle cell migration [GO:0007297]; ovarian fusome organization [GO:0030723]; ovarian nurse cell to oocyte transport [GO:0007300]; protein ubiquitination [GO:0016567] GO:0003779; GO:0005737; GO:0005856; GO:0007297; GO:0007300; GO:0007301; GO:0007349; GO:0016567; GO:0030036; GO:0030717; GO:0030723; GO:0031463; GO:0035183; GO:0035324; GO:0045172; GO:0048477 0 0 0 PF07707;PF00651;PF01344; Q6DIB5 CHOYP_LOC100701872.7.7 m.55495 sp MEG10_MOUSE 37.247 247 129 11 201 435 433 665 9.23E-28 121 MEG10_MOUSE reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) Megf10 Mus musculus (Mouse) 1147 homotypic cell-cell adhesion [GO:0034109]; muscle cell development [GO:0055001]; recognition of apoptotic cell [GO:0043654]; regulation of muscle cell differentiation [GO:0051147]; regulation of skeletal muscle tissue development [GO:0048641]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0001891; GO:0014719; GO:0014816; GO:0014841; GO:0016021; GO:0016323; GO:0034109; GO:0042995; GO:0043654; GO:0048641; GO:0051147; GO:0055001 0 0 0 PF12661;PF00053; Q9DCK3 CHOYP_CD53.1.1 m.1768 sp TSN4_MOUSE 28.082 146 99 2 37 182 97 236 9.23E-18 80.9 TSN4_MOUSE reviewed Tetraspanin-4 (Tspan-4) (Transmembrane 4 superfamily member 7) Tspan4 Tm4sf7 Mus musculus (Mouse) 238 cell surface receptor signaling pathway [GO:0007166]; protein complex assembly [GO:0006461] GO:0003823; GO:0005178; GO:0005886; GO:0005887; GO:0005925; GO:0006461; GO:0007166; GO:0031982 0 0 0 PF00335; Q9ESN6 CHOYP_BRAFLDRAFT_88218.3.8 m.17531 sp TRIM2_MOUSE 31 200 115 10 57 246 535 721 9.23E-14 73.9 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9UL16 CHOYP_THOC2.1.2 m.9632 sp CFA45_HUMAN 47.148 526 262 4 27 550 1 512 9.23E-116 357 CFA45_HUMAN reviewed Cilia- and flagella-associated protein 45 (Coiled-coil domain-containing protein 19) (Nasopharyngeal epithelium-specific protein 1) CFAP45 CCDC19 NESG1 Homo sapiens (Human) 551 0 GO:0005634; GO:0005654; GO:0005929 0 0 0 0 P20273 CHOYP_LOC100161316.2.2 m.42443 sp CD22_HUMAN 23.659 410 272 15 1 393 313 698 9.24E-18 91.7 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P42678 CHOYP_EIF1B.1.3 m.29107 sp SUI1_ANOGA 70.192 104 30 1 11 114 8 110 9.24E-49 154 SUI1_ANOGA reviewed Protein translation factor SUI1 homolog AGAP006459 Anopheles gambiae (African malaria mosquito) 110 regulation of translation [GO:0006417] GO:0003743; GO:0006417 0 0 cd11566; PF01253; P42678 CHOYP_EIF1B.2.3 m.48411 sp SUI1_ANOGA 70.192 104 30 1 11 114 8 110 9.24E-49 154 SUI1_ANOGA reviewed Protein translation factor SUI1 homolog AGAP006459 Anopheles gambiae (African malaria mosquito) 110 regulation of translation [GO:0006417] GO:0003743; GO:0006417 0 0 cd11566; PF01253; P42678 CHOYP_SETD2.1.1 m.25553 sp SUI1_ANOGA 70.192 104 30 1 11 114 8 110 9.24E-49 154 SUI1_ANOGA reviewed Protein translation factor SUI1 homolog AGAP006459 Anopheles gambiae (African malaria mosquito) 110 regulation of translation [GO:0006417] GO:0003743; GO:0006417 0 0 cd11566; PF01253; P83425 CHOYP_C1QL2.4.32 m.2766 sp HIP_MYTED 27.692 130 86 3 41 166 64 189 9.24E-08 53.1 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q4V8V2 CHOYP_MATN1.4.5 m.60313 sp NUD17_DANRE 34.653 101 57 3 9 106 197 291 9.24E-09 54.3 NUD17_DANRE reviewed Nucleoside diphosphate-linked moiety X motif 17 (Nudix motif 17) (EC 3.6.1.-) nudt17 zgc:114128 Danio rerio (Zebrafish) (Brachydanio rerio) 300 0 GO:0016787; GO:0046872 0 0 cd04694; PF00293; Q5R792 CHOYP_BRAFLDRAFT_115265.1.1 m.5158 sp ATG5_PONAB 52.045 269 125 3 1 265 1 269 9.24E-104 305 ATG5_PONAB reviewed Autophagy protein 5 (APG5-like) ATG5 APG5L Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 275 antigen processing and presentation of endogenous antigen [GO:0019883]; apoptotic process [GO:0006915]; blood vessel remodeling [GO:0001974]; cellular homeostasis [GO:0019725]; cellular response to starvation [GO:0009267]; heart contraction [GO:0060047]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of histone H4-K16 acetylation [GO:2000619]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; negative stranded viral RNA replication [GO:0039689]; negative thymic T cell selection [GO:0045060]; otolith development [GO:0048840]; positive regulation of mitophagy [GO:1903599]; positive regulation of mucus secretion [GO:0070257]; protein lipidation involved in autophagosome assembly [GO:0061739]; regulation of cilium assembly [GO:1902017]; regulation of cytokine secretion involved in immune response [GO:0002739]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; response to drug [GO:0042493]; response to fungus [GO:0009620]; vasodilation [GO:0042311]; ventricular cardiac muscle cell development [GO:0055015] GO:0001974; GO:0002739; GO:0005776; GO:0005930; GO:0006915; GO:0009267; GO:0009620; GO:0019725; GO:0019883; GO:0031397; GO:0034045; GO:0039689; GO:0042311; GO:0042493; GO:0043066; GO:0044233; GO:0045060; GO:0045087; GO:0048840; GO:0051279; GO:0055015; GO:0060047; GO:0061739; GO:0070257; GO:1902017; GO:1903599; GO:2000378; GO:2000619 0 0 0 PF04106; Q6H236 CHOYP_contig_011090 m.12784 sp PEG3_BOVIN 33.333 168 112 0 21 188 1336 1503 9.24E-13 69.3 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q8BIG4 CHOYP_FBX28.1.1 m.38682 sp FBX28_MOUSE 45.645 287 129 4 47 329 64 327 9.24E-72 232 FBX28_MOUSE reviewed F-box only protein 28 Fbxo28 D1Ertd578e Kiaa0483 Mus musculus (Mouse) 368 0 GO:0000776; GO:0000777 0 0 0 PF00646; Q8WWT9 CHOYP_LOC100692894.1.1 m.10137 sp S13A3_HUMAN 41.331 571 304 7 22 564 11 578 9.24E-146 437 S13A3_HUMAN reviewed Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) SLC13A3 NADC3 SDCT2 Homo sapiens (Human) 602 citrate transport [GO:0015746] GO:0005886; GO:0005887; GO:0015137; GO:0015141; GO:0015183; GO:0015362; GO:0015746; GO:0017153; GO:0070062 0 0 0 PF00939; Q99715 CHOYP_COEA1.1.2 m.2641 sp COCA1_HUMAN 36.889 225 132 6 56 275 432 651 9.24E-29 122 COCA1_HUMAN reviewed Collagen alpha-1(XII) chain COL12A1 COL12A1L Homo sapiens (Human) 3063 cell adhesion [GO:0007155]; collagen catabolic process [GO:0030574]; collagen fibril organization [GO:0030199]; endodermal cell differentiation [GO:0035987]; skeletal system development [GO:0001501] GO:0001501; GO:0005576; GO:0005595; GO:0005615; GO:0005788; GO:0007155; GO:0030020; GO:0030199; GO:0030574; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q9U3W6 CHOYP_LOC100375194.1.7 m.23470 sp MAB21_DROME 24.855 173 111 6 164 326 180 343 9.24E-07 54.7 MAB21_DROME reviewed Protein mab-21 mab-21 CG4746 Drosophila melanogaster (Fruit fly) 365 0 0 0 0 0 PF03281; P12001 CHOYP_RPL18.1.1 m.47907 sp RL18_RAT 73.737 99 26 0 11 109 1 99 9.25E-48 154 RL18_RAT reviewed 60S ribosomal protein L18 Rpl18 Rattus norvegicus (Rat) 188 liver regeneration [GO:0097421]; translation [GO:0006412] GO:0003723; GO:0003735; GO:0006412; GO:0022625; GO:0097421 0 0 0 PF17135; P84239 CHOYP_H3.2.2 m.27568 sp H3_URECA 100 136 0 0 1 136 1 136 9.25E-96 274 H3_URECA reviewed Histone H3 0 Urechis caupo (Innkeeper worm) (Spoonworm) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; P84239 CHOYP_LOC100902368.1.1 m.49966 sp H3_URECA 100 136 0 0 1 136 1 136 9.25E-96 274 H3_URECA reviewed Histone H3 0 Urechis caupo (Innkeeper worm) (Spoonworm) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; P84239 CHOYP_LOC101175374.1.1 m.14680 sp H3_URECA 100 136 0 0 1 136 1 136 9.25E-96 274 H3_URECA reviewed Histone H3 0 Urechis caupo (Innkeeper worm) (Spoonworm) 136 0 GO:0000786; GO:0003677; GO:0005634 0 0 0 PF00125; Q58EX7 CHOYP_LOC100377600.1.2 m.7858 sp PKHG4_HUMAN 54.372 366 166 1 1268 1633 724 1088 9.25E-127 431 PKHG4_HUMAN reviewed Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1) PLEKHG4 PRTPHN1 Homo sapiens (Human) 1191 activation of GTPase activity [GO:0090630]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023; GO:0090630 0 0 0 PF00621; Q5BKU9 CHOYP_PHUM_PHUM344520.1.1 m.44530 sp OXLD1_HUMAN 41.558 77 41 3 106 179 66 141 9.25E-13 65.5 OXLD1_HUMAN reviewed Oxidoreductase-like domain-containing protein 1 OXLD1 C17orf90 Homo sapiens (Human) 147 0 GO:0005739 0 0 0 PF09791; Q5FWL7 CHOYP_BRAFLDRAFT_117158.1.2 m.10507 sp ZDH15_XENLA 53.016 315 147 1 3 316 10 324 9.25E-128 371 ZDH15_XENLA reviewed Palmitoyltransferase ZDHHC15 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 15 homolog) (DHHC-15) zdhhc15 Xenopus laevis (African clawed frog) 338 0 GO:0008270; GO:0016021; GO:0019706 0 0 0 PF01529; Q5ZEQ8 CHOYP_LOC100376931.1.1 m.56978 sp FJX1_XIPMA 29.204 339 208 12 198 528 106 420 9.25E-33 133 FJX1_XIPMA reviewed Four-jointed box protein 1 (Four-jointed protein homolog) fjx1 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) 427 0 GO:0005576 0 0 0 0 Q5ZM33 CHOYP_LOC578284.1.1 m.30567 sp HP1B3_CHICK 37.647 170 88 6 290 446 259 423 9.25E-24 107 HP1B3_CHICK reviewed Heterochromatin protein 1-binding protein 3 HP1BP3 RCJMB04_3f4 Gallus gallus (Chicken) 559 "heterochromatin organization [GO:0070828]; nucleosome assembly [GO:0006334]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000786; GO:0003677; GO:0003682; GO:0005634; GO:0006334; GO:0006355; GO:0070828 0 0 0 PF00538; Q8C0J6 CHOYP_LOC100868520.1.1 m.44391 sp SWAHC_MOUSE 43.796 137 72 1 205 336 246 382 9.25E-35 139 SWAHC_MOUSE reviewed Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) Sowahc Ankrd57 Mus musculus (Mouse) 512 0 0 0 0 0 PF12796; Q8JZS9 CHOYP_DVIR_GJ10177.1.1 m.28121 sp RM48_MOUSE 25.6 125 92 1 66 189 86 210 9.25E-08 53.9 RM48_MOUSE reviewed "39S ribosomal protein L48, mitochondrial (L48mt) (MRP-L48)" Mrpl48 Mus musculus (Mouse) 211 0 GO:0005739; GO:0005761 0 0 0 PF00338; Q8K0U4 CHOYP_BRAFLDRAFT_208436.28.32 m.61327 sp HS12A_MOUSE 32.855 627 364 17 69 647 56 673 9.25E-86 285 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 A8C754 CHOYP_THADA.2.2 m.14601 sp THADA_CHICK 27.853 517 350 13 5 510 63 567 9.26E-44 169 THADA_CHICK reviewed Thyroid adenoma-associated protein homolog THADA Gallus gallus (Chicken) 1930 0 0 0 0 0 PF10350; B2RYI0 CHOYP_WDR91.1.1 m.12919 sp WDR91_RAT 37.01 816 415 18 1 790 2 744 9.26E-170 511 WDR91_RAT reviewed WD repeat-containing protein 91 Wdr91 Rattus norvegicus (Rat) 747 0 0 0 0 0 PF00400; D0Z9R0 CHOYP_LOC100211155.1.1 m.22235 sp TATD_EDWTE 34.783 276 161 5 157 430 1 259 9.26E-52 177 TATD_EDWTE reviewed 3'-5' ssDNA/RNA exonuclease TatD (EC 3.1.11.-) (EC 3.1.13.-) (DNase TatD) tatD ETAE_0153 Edwardsiella tarda (strain EIB202) 260 0 GO:0000175; GO:0000287; GO:0005737; GO:0008310; GO:0016888 0 0 0 PF01026; H2A0L6 CHOYP_NEMVEDRAFT_V1G201552.3.6 m.9104 sp HEX_PINMG 30.809 977 565 38 3 917 4 931 9.26E-112 374 HEX_PINMG reviewed Putative beta-hexosaminidase (EC 3.2.1.52) (Beta-N-acetylhexosaminidase) (Chitobiase) (N-acetyl-beta-glucosaminidase) 0 Pinctada margaritifera (Black-lipped pearl oyster) 1135 carbohydrate metabolic process [GO:0005975]; chitin catabolic process [GO:0006032] GO:0004563; GO:0005576; GO:0005975; GO:0006032; GO:0030247 PATHWAY: Glycan degradation; chitin degradation. {ECO:0000250|UniProtKB:Q04786}. 0 0 PF03173;PF00728; O09167 CHOYP_RS7.5.9 m.38701 sp RL21_MOUSE 73.832 107 28 0 1 107 1 107 9.26E-55 171 RL21_MOUSE reviewed 60S ribosomal protein L21 Rpl21 Mus musculus (Mouse) 160 translation [GO:0006412] GO:0003735; GO:0005730; GO:0005737; GO:0006412; GO:0016020; GO:0022625; GO:0044822 0 0 0 PF01157; O43301 CHOYP_LOC100368695.1.1 m.26746 sp HS12A_HUMAN 26.248 621 389 18 886 1442 58 673 9.26E-52 198 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 P11584 CHOYP_ITB1.3.4 m.28565 sp ITBX_DROME 35.766 137 76 6 405 536 643 772 9.26E-14 77.8 ITBX_DROME reviewed Integrin beta-PS (Position-specific antigen beta subunit) (Protein myospheroid) (Protein olfactory C) mys l(1)mys olfC CG1560 Drosophila melanogaster (Fruit fly) 846 "actin filament organization [GO:0007015]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; calcium-dependent cell-matrix adhesion [GO:0016340]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell-matrix adhesion [GO:0007160]; cell migration [GO:0016477]; cell-substrate adhesion [GO:0031589]; central nervous system development [GO:0007417]; central nervous system morphogenesis [GO:0021551]; determination of adult lifespan [GO:0008340]; dorsal closure [GO:0007391]; dorsal trunk growth, open tracheal system [GO:0035001]; epithelial cell migration, open tracheal system [GO:0007427]; flight behavior [GO:0007629]; germ-band extension [GO:0007377]; germ-line stem cell population maintenance [GO:0030718]; hemocyte migration [GO:0035099]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; integrin-mediated signaling pathway [GO:0007229]; larval heart development [GO:0007508]; maintenance of epithelial integrity, open tracheal system [GO:0035160]; midgut development [GO:0007494]; muscle attachment [GO:0016203]; muscle organ development [GO:0007517]; negative regulation of cell migration [GO:0030336]; pericardium morphogenesis [GO:0003344]; regulation of cell shape [GO:0008360]; regulation of stress fiber assembly [GO:0051492]; salivary gland development [GO:0007431]; sarcomere organization [GO:0045214]; sensory perception of smell [GO:0007608]; substrate adhesion-dependent cell spreading [GO:0034446]; substrate-dependent cell migration, cell extension [GO:0006930]; tracheal outgrowth, open tracheal system [GO:0007426]; visual perception [GO:0007601]" GO:0003344; GO:0004872; GO:0005886; GO:0005887; GO:0005925; GO:0005927; GO:0006930; GO:0007015; GO:0007155; GO:0007157; GO:0007160; GO:0007229; GO:0007298; GO:0007377; GO:0007391; GO:0007411; GO:0007417; GO:0007426; GO:0007427; GO:0007431; GO:0007475; GO:0007494; GO:0007508; GO:0007517; GO:0007601; GO:0007608; GO:0007629; GO:0008305; GO:0008340; GO:0008360; GO:0009925; GO:0016203; GO:0016324; GO:0016328; GO:0016339; GO:0016340; GO:0016477; GO:0021551; GO:0030336; GO:0030718; GO:0031252; GO:0031589; GO:0033627; GO:0034446; GO:0035001; GO:0035099; GO:0035160; GO:0043034; GO:0045214; GO:0046982; GO:0048803; GO:0050839; GO:0051492 0 0 0 PF07974;PF08725;PF07965;PF00362; Q56R14 CHOYP_TRI45.1.23 m.563 sp TRI33_XENLA 30.435 115 78 1 41 155 162 274 9.26E-07 50.8 TRI33_XENLA reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) trim33 ecto Xenopus laevis (African clawed frog) 1091 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; Q5K651 CHOYP_contig_002731 m.3015 sp SAMD9_HUMAN 32.911 158 91 4 105 260 182 326 9.26E-18 86.7 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q8NET6 CHOYP_LOC101159179.1.1 m.36406 sp CHSTD_HUMAN 27.876 226 141 4 129 348 98 307 9.26E-24 105 CHSTD_HUMAN reviewed Carbohydrate sulfotransferase 13 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 3) (Chondroitin 4-sulfotransferase 3) (C4ST-3) (C4ST3) CHST13 Homo sapiens (Human) 341 carbohydrate biosynthetic process [GO:0016051]; chondroitin sulfate biosynthetic process [GO:0030206] GO:0000139; GO:0001537; GO:0016021; GO:0016051; GO:0030206; GO:0047756 0 0 0 PF03567; Q91W96 CHOYP_ANAPC4.2.2 m.58250 sp APC4_MOUSE 26.217 267 163 10 1 248 529 780 9.26E-10 62.4 APC4_MOUSE reviewed Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4) Anapc4 D5Ertd249e Mus musculus (Mouse) 807 anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; protein K11-linked ubiquitination [GO:0070979]; regulation of mitotic metaphase/anaphase transition [GO:0030071] GO:0005634; GO:0005680; GO:0007067; GO:0019903; GO:0030071; GO:0031145; GO:0051301; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12896;PF12894; Q9D0K0 CHOYP_LOC100565104.1.1 m.8512 sp TBCD7_MOUSE 40.767 287 166 3 1 285 1 285 9.26E-71 223 TBCD7_MOUSE reviewed TBC1 domain family member 7 Tbc1d7 Mus musculus (Mouse) 293 activation of GTPase activity [GO:0090630]; negative regulation of cilium assembly [GO:1902018]; negative regulation of TOR signaling [GO:0032007]; positive regulation of protein ubiquitination [GO:0031398]; response to growth factor [GO:0070848] GO:0005096; GO:0016023; GO:0017137; GO:0031398; GO:0031410; GO:0032007; GO:0036064; GO:0070848; GO:0090630; GO:1902018 0 0 0 PF00566; O70511 CHOYP_AASI_1435.28.35 m.60443 sp ANK3_RAT 30.097 721 452 6 10 703 48 743 9.27E-98 334 ANK3_RAT reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Rattus norvegicus (Rat) 2622 cellular response to magnesium ion [GO:0071286]; magnesium ion homeostasis [GO:0010960]; membrane assembly [GO:0071709]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0005764; GO:0005886; GO:0007165; GO:0007528; GO:0008092; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016529; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0034112; GO:0042383; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P98164 CHOYP_LOC100649042.1.1 m.16679 sp LRP2_HUMAN 24.72 805 517 26 2 762 362 1121 9.27E-66 244 LRP2_HUMAN reviewed Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) LRP2 Homo sapiens (Human) 4655 aorta development [GO:0035904]; cell proliferation [GO:0008283]; coronary vasculature development [GO:0060976]; endocytosis [GO:0006897]; forebrain development [GO:0030900]; lipid metabolic process [GO:0006629]; protein glycosylation [GO:0006486]; receptor-mediated endocytosis [GO:0006898]; retinoid metabolic process [GO:0001523]; ventricular septum development [GO:0003281]; vitamin D metabolic process [GO:0042359] GO:0001523; GO:0003281; GO:0005041; GO:0005509; GO:0005764; GO:0005765; GO:0005768; GO:0005783; GO:0005794; GO:0005886; GO:0005905; GO:0006486; GO:0006629; GO:0006897; GO:0006898; GO:0008283; GO:0016021; GO:0016324; GO:0030139; GO:0030900; GO:0031526; GO:0035904; GO:0042359; GO:0042954; GO:0043235; GO:0060976; GO:0070062 0 0 0 PF12662;PF07645;PF00057;PF00058; Q14693 CHOYP_LOC100369049.1.1 m.31638 sp LPIN1_HUMAN 34.848 330 168 10 1 326 1 287 9.27E-38 149 LPIN1_HUMAN reviewed Phosphatidate phosphatase LPIN1 (EC 3.1.3.4) (Lipin-1) LPIN1 KIAA0188 Homo sapiens (Human) 890 "cellular response to insulin stimulus [GO:0032869]; fatty acid catabolic process [GO:0009062]; mitotic nuclear envelope disassembly [GO:0007077]; organ regeneration [GO:0031100]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]; triglyceride biosynthetic process [GO:0019432]; triglyceride mobilization [GO:0006642]" GO:0003713; GO:0005634; GO:0005635; GO:0005654; GO:0005737; GO:0005741; GO:0005789; GO:0005829; GO:0006351; GO:0006642; GO:0006646; GO:0006656; GO:0007077; GO:0008195; GO:0009062; GO:0019432; GO:0031100; GO:0031965; GO:0032869; GO:0045944 0 0 0 PF16876;PF04571;PF08235; Q63421 CHOYP_LOC100376069.2.5 m.16079 sp PDE1C_RAT 47.853 326 148 4 47 364 5 316 9.27E-92 293 PDE1C_RAT reviewed "Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17)" Pde1c Rattus norvegicus (Rat) 768 cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; negative regulation of insulin secretion [GO:0046676]; response to calcium ion [GO:0051592]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165] GO:0004115; GO:0004117; GO:0006198; GO:0007165; GO:0007608; GO:0030552; GO:0043025; GO:0046069; GO:0046676; GO:0046872; GO:0048101; GO:0051592 0 0 0 PF00233;PF08499; Q6DF67 CHOYP_NEMVEDRAFT_V1G165649.1.1 m.2893 sp ISOC2_XENTR 53.846 195 90 0 16 210 5 199 9.27E-83 247 ISOC2_XENTR reviewed Isochorismatase domain-containing protein 2 isoc2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 205 metabolic process [GO:0008152] GO:0003824; GO:0005737; GO:0008152 0 0 0 PF00857; Q6DJH2 CHOYP_ADPPT.1.1 m.9312 sp ADPPT_XENLA 44.84 281 146 4 2 274 14 293 9.27E-78 241 ADPPT_XENLA reviewed L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.-) (4'-phosphopantetheinyl transferase) (Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) (AASD-PPT) aasdhppt Xenopus laevis (African clawed frog) 302 fatty acid biosynthetic process [GO:0006633] GO:0000287; GO:0005737; GO:0006633; GO:0008897 0 0 0 PF01648; Q9Y2P5 CHOYP_SLC27A2.1.1 m.65358 sp S27A5_HUMAN 45.854 410 214 3 33 441 275 677 9.27E-122 373 S27A5_HUMAN reviewed "Bile acyl-CoA synthetase (BACS) (EC 6.2.1.7) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Fatty acid transport protein 5) (FATP-5) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)" SLC27A5 ACSB ACSVL6 FACVL3 FATP5 Homo sapiens (Human) 690 bile acid and bile salt transport [GO:0015721]; bile acid biosynthetic process [GO:0006699]; ketone body biosynthetic process [GO:0046951]; plasma membrane long-chain fatty acid transport [GO:0015911]; triglyceride mobilization [GO:0006642]; very long-chain fatty acid metabolic process [GO:0000038] GO:0000038; GO:0004467; GO:0005524; GO:0005783; GO:0005789; GO:0006642; GO:0006699; GO:0009925; GO:0015245; GO:0015721; GO:0015911; GO:0030176; GO:0031957; GO:0043234; GO:0046951; GO:0047747 0 0 0 PF00501;PF13193; O15040 CHOYP_BRAFLDRAFT_216841.4.4 m.58278 sp TCPR2_HUMAN 33.333 624 378 15 954 1549 798 1411 9.28E-98 349 TCPR2_HUMAN reviewed Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) TECPR2 KIAA0297 KIAA0329 Homo sapiens (Human) 1411 autophagy [GO:0006914] GO:0006914 0 0 0 PF06462; P10041 CHOYP_LOC585137.1.1 m.516 sp DL_DROME 29.909 331 188 13 1 290 1 328 9.28E-28 120 DL_DROME reviewed Neurogenic locus protein delta Dl CG3619 Drosophila melanogaster (Fruit fly) 833 "actin filament organization [GO:0007015]; antennal morphogenesis [GO:0048800]; apposition of dorsal and ventral imaginal disc-derived wing surfaces [GO:0007475]; asymmetric cell division [GO:0008356]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye retinal cell programmed cell death [GO:0046667]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; ectoderm development [GO:0007398]; establishment of ommatidial planar polarity [GO:0042067]; establishment of planar polarity [GO:0001736]; germ-line stem cell population maintenance [GO:0030718]; glial cell migration [GO:0008347]; imaginal disc-derived leg morphogenesis [GO:0007480]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein morphogenesis [GO:0008586]; imaginal disc-derived wing vein specification [GO:0007474]; lateral inhibition [GO:0046331]; mesoderm development [GO:0007498]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; ommatidial rotation [GO:0016318]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of mitotic cell cycle [GO:0045931]; R3/R4 cell fate commitment [GO:0007464]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of R8 cell spacing in compound eye [GO:0045468]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; sensory perception of pain [GO:0019233]; sleep [GO:0030431]; stem cell differentiation [GO:0048863]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]" GO:0001708; GO:0001736; GO:0005102; GO:0005112; GO:0005509; GO:0005768; GO:0005886; GO:0005912; GO:0007015; GO:0007155; GO:0007219; GO:0007298; GO:0007314; GO:0007398; GO:0007399; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007451; GO:0007460; GO:0007464; GO:0007474; GO:0007475; GO:0007476; GO:0007480; GO:0007498; GO:0008284; GO:0008347; GO:0008356; GO:0008407; GO:0008586; GO:0009986; GO:0016021; GO:0016318; GO:0016330; GO:0019233; GO:0030139; GO:0030431; GO:0030707; GO:0030713; GO:0030718; GO:0030720; GO:0031410; GO:0035003; GO:0035155; GO:0035157; GO:0036011; GO:0042067; GO:0042676; GO:0045465; GO:0045468; GO:0045931; GO:0046331; GO:0046667; GO:0048190; GO:0048477; GO:0048749; GO:0048800; GO:0048863; GO:0050768 0 0 0 PF01414;PF00008;PF12661;PF07657; P11167 CHOYP_AGAP_AGAP007340.2.2 m.30731 sp GTR1_RAT 44.699 481 249 5 35 515 6 469 9.28E-144 426 GTR1_RAT reviewed "Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1)" Slc2a1 Glut-1 Glut1 Rattus norvegicus (Rat) 492 cellular response to glucose starvation [GO:0042149]; dehydroascorbic acid transport [GO:0070837]; glucose transport [GO:0015758]; protein complex assembly [GO:0006461]; response to osmotic stress [GO:0006970]; xenobiotic transport [GO:0042908] GO:0001939; GO:0005351; GO:0005355; GO:0005737; GO:0005829; GO:0005886; GO:0005887; GO:0005901; GO:0005911; GO:0006461; GO:0006970; GO:0015758; GO:0016021; GO:0016323; GO:0016324; GO:0019900; GO:0030496; GO:0030864; GO:0033300; GO:0042149; GO:0042470; GO:0042908; GO:0042910; GO:0043621; GO:0055056; GO:0070062; GO:0070837; GO:0072562 0 0 cd06174; PF00083; P16257 CHOYP_DGRI_GH11232.1.1 m.16503 sp TSPO_RAT 43.827 162 90 1 28 188 1 162 9.28E-46 151 TSPO_RAT reviewed Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR) Tspo Bzrp Mbr Rattus norvegicus (Rat) 169 adrenal gland development [GO:0030325]; aging [GO:0007568]; behavioral response to pain [GO:0048266]; cellular hypotonic response [GO:0071476]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; contact inhibition [GO:0060242]; establishment of protein localization to mitochondrion [GO:0072655]; glial cell migration [GO:0008347]; ion transport [GO:0006811]; lipid transport [GO:0006869]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of mitophagy [GO:1903147]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tumor necrosis factor production [GO:0032720]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of necrotic cell death [GO:0010940]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of steroid biosynthetic process [GO:0050810]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to manganese ion [GO:0010042]; response to pain [GO:0048265]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to vitamin B1 [GO:0010266]; steroid biosynthetic process [GO:0006694] GO:0005497; GO:0005739; GO:0005741; GO:0006694; GO:0006811; GO:0006821; GO:0006869; GO:0007568; GO:0008347; GO:0008503; GO:0010042; GO:0010266; GO:0010940; GO:0014012; GO:0016021; GO:0030325; GO:0031397; GO:0031965; GO:0032570; GO:0032720; GO:0033574; GO:0042493; GO:0043065; GO:0045019; GO:0048265; GO:0048266; GO:0048678; GO:0050810; GO:0051901; GO:0051928; GO:0060242; GO:0060252; GO:0060253; GO:0070062; GO:0071222; GO:0071294; GO:0071476; GO:0072655; GO:0072656; GO:1903147; GO:1903579; GO:2000379 0 0 0 PF03073; P19157 CHOYP_GSTP1.1.2 m.29677 sp GSTP1_MOUSE 50.711 211 99 3 24 230 1 210 9.28E-68 210 GSTP1_MOUSE reviewed Glutathione S-transferase P 1 (Gst P1) (EC 2.5.1.18) (GST YF-YF) (GST class-pi) (GST-piB) (Preadipocyte growth factor) Gstp1 Gstpib Mus musculus (Mouse) 210 cellular response to cell-matrix adhesion [GO:0071460]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; common myeloid progenitor cell proliferation [GO:0035726]; glutathione metabolic process [GO:0006749]; negative regulation of acute inflammatory response [GO:0002674]; negative regulation of apoptotic process [GO:0043066]; negative regulation of biosynthetic process [GO:0009890]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of leukocyte proliferation [GO:0070664]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of neutrophil aggregation [GO:2000429]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; negative regulation of peroxidase activity [GO:2000469]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of tumor necrosis factor production [GO:0032720]; oligodendrocyte development [GO:0014003]; organ regeneration [GO:0031100]; positive regulation of superoxide anion generation [GO:0032930]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of stress-activated MAPK cascade [GO:0032872]; response to amino acid [GO:0043200]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to L-ascorbic acid [GO:0033591]; response to nutrient levels [GO:0031667]; response to reactive oxygen species [GO:0000302]; response to toxic substance [GO:0009636]; xenobiotic metabolic process [GO:0006805] GO:0000302; GO:0002674; GO:0004364; GO:0005615; GO:0005622; GO:0005634; GO:0005737; GO:0005739; GO:0005829; GO:0005886; GO:0006749; GO:0006805; GO:0008144; GO:0008432; GO:0009636; GO:0009890; GO:0014003; GO:0019207; GO:0031100; GO:0031667; GO:0031982; GO:0032355; GO:0032691; GO:0032720; GO:0032869; GO:0032872; GO:0032873; GO:0032930; GO:0033591; GO:0035726; GO:0035730; GO:0035731; GO:0043066; GO:0043124; GO:0043200; GO:0043234; GO:0043407; GO:0043508; GO:0045471; GO:0048147; GO:0051771; GO:0070062; GO:0070372; GO:0070373; GO:0070664; GO:0071222; GO:0071364; GO:0071385; GO:0071460; GO:0071638; GO:0097057; GO:2000429; GO:2000469; GO:2001237 0 0 0 PF14497;PF02798; P29691 CHOYP_EEF2.1.2 m.44029 sp EF2_CAEEL 73.81 126 33 0 1 126 727 852 9.28E-63 207 EF2_CAEEL reviewed Elongation factor 2 (EF-2) eef-2 F25H5.4 Caenorhabditis elegans 852 translation [GO:0006412] GO:0003746; GO:0003924; GO:0005525; GO:0005622; GO:0005737; GO:0006412 0 0 0 PF00679;PF14492;PF03764;PF03144; P58659 CHOYP_EVA1C.1.1 m.8155 sp EVA1C_MOUSE 29.63 378 198 8 4 377 31 344 9.28E-51 181 EVA1C_MOUSE reviewed Protein eva-1 homolog C (Protein FAM176C) Eva1c Fam176c Mus musculus (Mouse) 440 0 GO:0005886; GO:0016021; GO:0030246 0 0 0 PF02140; P83425 CHOYP_LOC100712692.1.1 m.63199 sp HIP_MYTED 31.884 138 84 3 24 157 82 213 9.28E-11 60.8 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; P85107 CHOYP_TGS1.2.2 m.60342 sp TGS1_RAT 63.83 141 51 0 1 141 700 840 9.28E-59 201 TGS1_RAT reviewed Trimethylguanosine synthase (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT) Tgs1 Ncoa6ip Pimt Rattus norvegicus (Rat) 850 "7-methylguanosine RNA capping [GO:0009452]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005615; GO:0005730; GO:0005737; GO:0006351; GO:0006355; GO:0009452; GO:0015030; GO:0071164 0 0 0 PF09445; Q149M9 CHOYP_LOC100366460.2.2 m.53099 sp NWD1_HUMAN 26.976 797 524 21 15 790 242 1001 9.28E-64 243 NWD1_HUMAN reviewed NACHT domain- and WD repeat-containing protein 1 NWD1 Homo sapiens (Human) 1564 0 GO:0005524; GO:0005829 0 0 0 PF12894;PF00400; Q5R4W3 CHOYP_DPOE3.1.2 m.6952 sp DPOE3_PONAB 79.048 105 22 0 1 105 1 105 9.28E-58 181 DPOE3_PONAB reviewed DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) POLE3 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 147 histone H3 acetylation [GO:0043966] GO:0003677; GO:0003887; GO:0005671; GO:0008622; GO:0043966 0 0 0 PF00808; Q5RC53 CHOYP_LOC100705526.1.1 m.62742 sp GLRX2_PONAB 48.421 95 49 0 33 127 57 151 9.28E-30 108 GLRX2_PONAB reviewed "Glutaredoxin-2, mitochondrial" GLRX2 GRX2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 161 cell redox homeostasis [GO:0045454] GO:0005739; GO:0009055; GO:0015035; GO:0045454; GO:0046872; GO:0051537 0 0 0 PF00462; Q5T4T1 CHOYP_LOC100647038.2.4 m.17047 sp T170B_HUMAN 40.777 103 61 0 11 113 16 118 9.28E-23 89.4 T170B_HUMAN reviewed Transmembrane protein 170B TMEM170B Homo sapiens (Human) 132 0 GO:0016021 0 0 0 PF10190; Q8CG64 CHOYP_LOC100378266.1.1 m.25135 sp FKRP_MOUSE 41.509 371 209 6 31 399 121 485 9.28E-104 318 FKRP_MOUSE reviewed Fukutin-related protein (EC 2.-.-.-) Fkrp Mus musculus (Mouse) 494 glycoprotein biosynthetic process [GO:0009101]; protein O-linked mannosylation [GO:0035269]; protein processing [GO:0016485] GO:0000139; GO:0005615; GO:0005791; GO:0005794; GO:0009101; GO:0016021; GO:0016485; GO:0016740; GO:0035269; GO:0042383 PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9H9S5}. 0 0 PF04991; Q8TC84 CHOYP_LOC100373728.1.1 m.59746 sp FANK1_HUMAN 49.541 327 163 2 1 326 7 332 9.28E-116 342 FANK1_HUMAN reviewed Fibronectin type 3 and ankyrin repeat domains protein 1 FANK1 HSD13 UNQ6504/PRO21382 Homo sapiens (Human) 345 0 GO:0005654; GO:0005737 0 0 0 PF12796; Q9S9V0 CHOYP_CDPKV.1.1 m.55626 sp CDPKV_ARATH 31.25 128 87 1 39 165 337 464 9.28E-12 65.9 CDPKV_ARATH reviewed Calcium-dependent protein kinase 31 (EC 2.7.11.1) CPK31 At4g04695 T19J18.7 Arabidopsis thaliana (Mouse-ear cress) 484 abscisic acid-activated signaling pathway [GO:0009738]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; response to salicylic acid [GO:0009751] GO:0004683; GO:0005509; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0009738; GO:0009751; GO:0009931; GO:0016020; GO:0018105; GO:0035556; GO:0046777 0 0 0 PF13499;PF00069; Q9UGM3 CHOYP_LOC580940.1.2 m.13174 sp DMBT1_HUMAN 42.245 490 206 9 1 416 157 643 9.28E-100 329 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A0JM13 CHOYP_C2CD3.1.1 m.57027 sp C2CD3_XENTR 44.118 136 75 1 1 136 52 186 9.29E-33 132 C2CD3_XENTR reviewed C2 domain-containing protein 3 c2cd3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 2311 centriole elongation [GO:0061511]; nonmotile primary cilium assembly [GO:0035058]; protein localization to centrosome [GO:0071539] GO:0005814; GO:0005929; GO:0034451; GO:0035058; GO:0061511; GO:0071539 0 0 0 PF00168; P08548 CHOYP_LOC100536368.1.2 m.56556 sp LIN1_NYCCO 28.97 466 323 7 142 603 385 846 9.29E-46 180 LIN1_NYCCO reviewed LINE-1 reverse transcriptase homolog (EC 2.7.7.49) 0 Nycticebus coucang (Slow loris) 1260 0 GO:0003964; GO:0046872 0 0 0 PF08333;PF03372;PF00078; P0DMW7 CHOYP_LOC100402577.1.1 m.44548 sp VKT3B_ACTEQ 47.458 59 31 0 245 303 1 59 9.29E-11 59.7 VKT3B_ACTEQ reviewed PI-actitoxin-Aeq3b (PI-AITX-Aeq3b) (Kunitz-type proteinase inhibitor AEPI-II) 0 Actinia equina (Beadlet anemone) 59 0 GO:0004867; GO:0005576; GO:0042151 0 0 0 PF00014; Q14191 CHOYP_LOC575600.1.1 m.27852 sp WRN_HUMAN 31.441 229 131 10 13 235 538 746 9.29E-26 108 WRN_HUMAN reviewed "Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)" WRN RECQ3 RECQL2 Homo sapiens (Human) 1432 aging [GO:0007568]; base-excision repair [GO:0006284]; brain development [GO:0007420]; cell aging [GO:0007569]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; DNA metabolic process [GO:0006259]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; multicellular organism aging [GO:0010259]; nucleolus to nucleoplasm transport [GO:0032066]; positive regulation of hydrolase activity [GO:0051345]; protein sumoylation [GO:0016925]; regulation of apoptotic process [GO:0042981]; regulation of growth rate [GO:0040009]; regulation of signal transduction by p53 class mediator [GO:1901796]; replication fork processing [GO:0031297]; replicative cell aging [GO:0001302]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; strand displacement [GO:0000732]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722] GO:0000287; GO:0000403; GO:0000405; GO:0000722; GO:0000723; GO:0000731; GO:0000732; GO:0000784; GO:0001302; GO:0003677; GO:0003678; GO:0003682; GO:0004003; GO:0004386; GO:0004527; GO:0005524; GO:0005654; GO:0005730; GO:0005737; GO:0005813; GO:0006259; GO:0006260; GO:0006284; GO:0006302; GO:0006974; GO:0006979; GO:0007420; GO:0007568; GO:0007569; GO:0008408; GO:0009267; GO:0009378; GO:0010225; GO:0010259; GO:0016887; GO:0016925; GO:0030145; GO:0031297; GO:0032066; GO:0032403; GO:0040009; GO:0042803; GO:0042981; GO:0043005; GO:0043138; GO:0043140; GO:0051345; GO:0051880; GO:0071480; GO:1901796 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; Q28CH8 CHOYP_LOC585872.4.6 m.52325 sp YIPF6_XENTR 63.462 156 49 2 10 165 19 166 9.29E-68 208 YIPF6_XENTR reviewed Protein YIPF6 (YIP1 family member 6) yipf6 TGas105o14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 233 0 GO:0016021 0 0 0 PF04893; Q5SNX7 CHOYP_LOC100376265.4.4 m.28000 sp GALC_DANRE 44.241 382 201 8 1 379 287 659 9.29E-100 312 GALC_DANRE reviewed Galactocerebrosidase (GALCERase) (EC 3.2.1.46) (Galactosylceramidase) galc galca si:ch211-199l3.4 zgc:92561 Danio rerio (Zebrafish) (Brachydanio rerio) 660 carbohydrate metabolic process [GO:0005975]; galactosylceramide catabolic process [GO:0006683] GO:0004336; GO:0005764; GO:0005975; GO:0006683 0 0 0 PF02057; Q99M80 CHOYP_PTPRT.34.45 m.55496 sp PTPRT_MOUSE 29.539 694 444 16 392 1053 773 1453 9.29E-79 286 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9SF85 CHOYP_LOC100371695.1.1 m.10063 sp ADK1_ARATH 57.227 339 142 2 28 365 7 343 9.29E-143 411 ADK1_ARATH reviewed Adenosine kinase 1 (AK 1) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase 1) ADK1 At3g09820 F8A24.13 Arabidopsis thaliana (Mouse-ear cress) 344 adenosine salvage [GO:0006169]; AMP salvage [GO:0044209]; response to cadmium ion [GO:0046686]; response to trehalose-6-phosphate [GO:0080094]; viral process [GO:0016032] GO:0004001; GO:0005507; GO:0005524; GO:0005829; GO:0005886; GO:0006169; GO:0009506; GO:0009507; GO:0016020; GO:0016032; GO:0044209; GO:0046686; GO:0048046; GO:0080094 PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. 0 0 PF00294; B0BM24 CHOYP_LOC100378967.1.1 m.62298 sp F161A_XENTR 36.192 478 235 12 298 766 184 600 9.30E-74 256 F161A_XENTR reviewed Protein FAM161A fam161a Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 659 cell projection organization [GO:0030030] GO:0005737; GO:0005856; GO:0005929; GO:0030030 0 0 0 PF10595; O00461 CHOYP_GOLI4.4.4 m.59175 sp GOLI4_HUMAN 26.829 205 125 1 12 191 14 218 9.30E-11 64.3 GOLI4_HUMAN reviewed "Golgi integral membrane protein 4 (Golgi integral membrane protein, cis) (GIMPc) (Golgi phosphoprotein 4) (Golgi-localized phosphoprotein of 130 kDa) (Golgi phosphoprotein of 130 kDa)" GOLIM4 GIMPC GOLPH4 GPP130 Homo sapiens (Human) 696 transport [GO:0006810] GO:0000139; GO:0005654; GO:0005794; GO:0005796; GO:0005801; GO:0006810; GO:0010008; GO:0016020; GO:0016021; GO:0030133; GO:0030139; GO:0032580 0 0 0 0 O70157 CHOYP_LOC100121991.1.1 m.13777 sp TOP3A_MOUSE 45.902 122 46 4 2 106 821 939 9.30E-24 99.4 TOP3A_MOUSE reviewed DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha) Top3a Top3 Mus musculus (Mouse) 1003 DNA topological change [GO:0006265] GO:0003677; GO:0003916; GO:0003917; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0006265; GO:0008270; GO:0016605 0 0 cd00186; PF01131;PF01751;PF01396;PF06839; P34152 CHOYP_FAK2.1.1 m.63819 sp FAK1_MOUSE 24.359 234 143 9 129 358 520 723 9.30E-09 62.4 FAK1_MOUSE reviewed Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) Ptk2 Fadk Fak Fak1 Kiaa4203 Mus musculus (Mouse) 1090 angiogenesis [GO:0001525]; axon guidance [GO:0007411]; blood vessel development [GO:0001568]; cell adhesion [GO:0007155]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system neuron axonogenesis [GO:0021955]; endothelial cell migration [GO:0043542]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of nucleus localization [GO:0040023]; extracellular matrix organization [GO:0030198]; growth hormone receptor signaling pathway [GO:0060396]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of organ growth [GO:0046621]; negative regulation of synapse assembly [GO:0051964]; neuron migration [GO:0001764]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570] GO:0000226; GO:0001525; GO:0001568; GO:0001570; GO:0001725; GO:0001764; GO:0001932; GO:0001934; GO:0003779; GO:0004672; GO:0004713; GO:0004715; GO:0004871; GO:0005102; GO:0005524; GO:0005634; GO:0005737; GO:0005815; GO:0005829; GO:0005886; GO:0005925; GO:0007155; GO:0007172; GO:0007173; GO:0007179; GO:0007229; GO:0007411; GO:0008284; GO:0008360; GO:0008432; GO:0010632; GO:0014068; GO:0016324; GO:0018108; GO:0019901; GO:0021955; GO:0022408; GO:0030027; GO:0030155; GO:0030198; GO:0030335; GO:0031234; GO:0033628; GO:0038083; GO:0040023; GO:0042127; GO:0042169; GO:0043066; GO:0043542; GO:0045087; GO:0045667; GO:0045860; GO:0046621; GO:0046777; GO:0048010; GO:0048013; GO:0048471; GO:0050771; GO:0051893; GO:0051897; GO:0051964; GO:0060396; GO:0071560; GO:1900024; GO:2000060; GO:2000811 0 0 0 PF00373;PF03623;PF07714; P49321 CHOYP_NASP.4.4 m.56613 sp NASP_HUMAN 44.141 256 109 8 146 379 510 753 9.30E-55 196 NASP_HUMAN reviewed Nuclear autoantigenic sperm protein (NASP) NASP Homo sapiens (Human) 788 blastocyst development [GO:0001824]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone exchange [GO:0043486]; male gonad development [GO:0008584]; nucleosome assembly [GO:0006334]; protein transport [GO:0015031]; response to testosterone [GO:0033574] GO:0000790; GO:0001824; GO:0005634; GO:0005654; GO:0005737; GO:0006260; GO:0006334; GO:0006335; GO:0006336; GO:0007049; GO:0008283; GO:0008584; GO:0015031; GO:0032403; GO:0033574; GO:0043234; GO:0043486; GO:0051879 0 0 0 PF10516; P80311 CHOYP_PPIB.1.4 m.20263 sp PPIB_BOVIN 60.8 125 43 2 29 153 39 157 9.30E-46 152 PPIB_BOVIN reviewed Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Bos taurus (Bovine) 216 bone development [GO:0060348]; chaperone-mediated protein folding [GO:0061077]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of multicellular organism growth [GO:0040018]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821] GO:0000413; GO:0003755; GO:0005634; GO:0005788; GO:0005925; GO:0016020; GO:0032403; GO:0032991; GO:0034663; GO:0040018; GO:0042277; GO:0042470; GO:0044822; GO:0044829; GO:0048471; GO:0050821; GO:0060348; GO:0061077; GO:0070062 0 0 0 PF00160; Q3SZE2 CHOYP_LOC100694901.3.3 m.66949 sp PFD1_BOVIN 57.143 119 51 0 31 149 1 119 9.30E-42 138 PFD1_BOVIN reviewed Prefoldin subunit 1 PFDN1 Bos taurus (Bovine) 122 chaperone mediated protein folding independent of cofactor [GO:0051086]; protein folding [GO:0006457] GO:0005829; GO:0006457; GO:0016272; GO:0051086 0 0 0 PF01920; Q4LDE5 CHOYP_TSP_10958.1.1 m.46460 sp SVEP1_HUMAN 29.71 414 267 13 238 646 1218 1612 9.30E-41 167 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q54F25 CHOYP_CLN3.1.2 m.23695 sp CLN3_DICDI 38.795 415 220 9 5 396 8 411 9.30E-84 265 CLN3_DICDI reviewed Battenin (Protein CLN3 homolog) cln3 DDB_G0291157 Dictyostelium discoideum (Slime mold) 421 arginine transport [GO:0015809]; negative regulation of cell proliferation [GO:0008285]; pinocytosis [GO:0006907]; regulation of intracellular pH [GO:0051453]; regulation of sorocarp development [GO:0031156]; secretion [GO:0046903]; vacuolar transport [GO:0007034]; vacuole organization [GO:0007033] GO:0000331; GO:0005765; GO:0006907; GO:0007033; GO:0007034; GO:0008285; GO:0015809; GO:0030139; GO:0031156; GO:0031301; GO:0046903; GO:0051453 0 0 0 PF02487; Q5M865 CHOYP_PAGR1.1.1 m.18447 sp PAGR1_RAT 34.682 173 96 8 8 175 85 245 9.30E-09 57.4 PAGR1_RAT reviewed PAXIP1-associated glutamate-rich protein 1 (PAXIP1-associated protein 1) (PTIP-associated protein 1) PAGR1 Rattus norvegicus (Rat) 253 "DNA recombination [GO:0006310]; DNA repair [GO:0006281]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006281; GO:0006310; GO:0006351; GO:0006355; GO:0035097 0 0 0 PF15364; Q6YKA8 CHOYP_BM1_39900.1.1 m.38018 sp DRK_DROSI 47.312 93 47 1 1 91 84 176 9.30E-24 92.8 DRK_DROSI reviewed Protein E(sev)2B (Downstream of receptor kinase) (Protein enhancer of sevenless 2B) (SH2-SH3 adapter protein drk) drk E(sev)2B Drosophila simulans (Fruit fly) 211 0 GO:0004871; GO:0005070; GO:0005886 0 0 0 PF00017;PF00018; Q7SXM7 CHOYP_PRP31.4.6 m.40547 sp PRP31_DANRE 72.477 218 59 1 2 219 91 307 9.30E-113 334 PRP31_DANRE reviewed U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Danio rerio (Zebrafish) (Brachydanio rerio) 508 "mRNA splicing, via spliceosome [GO:0000398]; retina development in camera-type eye [GO:0060041]; spliceosomal tri-snRNP complex assembly [GO:0000244]" GO:0000244; GO:0000398; GO:0003723; GO:0005687; GO:0005690; GO:0046540; GO:0060041; GO:0071011; GO:0071339; GO:0097526 0 0 0 PF01798;PF09785; Q8BYI9 CHOYP_USH2A.5.6 m.61789 sp TENR_MOUSE 23.779 614 339 32 86 664 426 945 9.30E-14 79.3 TENR_MOUSE reviewed Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) Tnr Mus musculus (Mouse) 1358 "associative learning [GO:0008306]; extracellular matrix organization [GO:0030198]; locomotory exploration behavior [GO:0035641]; long-term synaptic potentiation [GO:0060291]; modulation of synaptic transmission [GO:0050804]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in regeneration [GO:0048692]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic transmission [GO:0050805]; neuromuscular process controlling balance [GO:0050885]; neuron cell-cell adhesion [GO:0007158]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; positive regulation of transmission of nerve impulse [GO:0051971]; synapse organization [GO:0050808]; telencephalon cell migration [GO:0022029]" GO:0005578; GO:0005634; GO:0005654; GO:0005737; GO:0007158; GO:0008306; GO:0009986; GO:0010977; GO:0022029; GO:0022408; GO:0030198; GO:0030517; GO:0035641; GO:0045121; GO:0046625; GO:0048692; GO:0050804; GO:0050805; GO:0050808; GO:0050885; GO:0051968; GO:0051971; GO:0060291; GO:0072534 0 0 0 PF00147;PF00041; Q91VA6 CHOYP_PDIP2.1.1 m.26398 sp PDIP2_MOUSE 31.487 343 191 8 24 347 49 366 9.30E-45 160 PDIP2_MOUSE reviewed Polymerase delta-interacting protein 2 Poldip2 Mus musculus (Mouse) 368 mitochondrion morphogenesis [GO:0070584]; negative regulation of macroautophagy [GO:0016242]; positive regulation of mitotic cell cycle [GO:0045931] GO:0003677; GO:0005634; GO:0005739; GO:0016242; GO:0030674; GO:0042645; GO:0045931; GO:0070584 0 0 0 PF04379;PF08755; Q93129 CHOYP_LOC752782.1.1 m.53938 sp ACTC_BRABE 99.034 207 2 0 1 207 44 250 9.30E-152 428 ACTC_BRABE reviewed "Actin, cytoplasmic (BbCA1) [Cleaved into: Actin, cytoplasmic, N-terminally processed]" 0 Branchiostoma belcheri (Amphioxus) 375 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q9P2D8 CHOYP_UNC79.4.4 m.48853 sp UNC79_HUMAN 35.342 863 447 18 1 810 637 1441 9.30E-151 505 UNC79_HUMAN reviewed Protein unc-79 homolog UNC79 KIAA1409 Homo sapiens (Human) 2635 behavioral response to ethanol [GO:0048149]; ion transmembrane transport [GO:0034220]; multicellular organism growth [GO:0035264] GO:0005886; GO:0016021; GO:0034220; GO:0035264; GO:0048149 0 0 0 0 Q9QZS6 CHOYP_HS3SB.2.2 m.63788 sp HS3SB_MOUSE 60.656 244 96 0 1 244 146 389 9.30E-108 319 HS3SB_MOUSE reviewed Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (EC 2.8.2.30) (Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1) (3-OST-3B) (Heparan sulfate 3-O-sulfotransferase 3B1) (m3-OST-3B) Hs3st3b1 3ost3b1 Hs3st3b Mus musculus (Mouse) 390 protein sulfation [GO:0006477] GO:0000139; GO:0005887; GO:0006477; GO:0008467; GO:0033872 0 0 0 PF00685; O75179 CHOYP_ANKHD1.1.1 m.39968 sp ANR17_HUMAN 33.949 433 255 16 143 558 236 654 9.31E-45 174 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P17078 CHOYP_LOC100711334.1.1 m.16928 sp RL35_RAT 76.19 105 25 0 4 108 2 106 9.31E-46 150 RL35_RAT reviewed 60S ribosomal protein L35 Rpl35 Rattus norvegicus (Rat) 123 "cellular response to UV-B [GO:0071493]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; translation [GO:0006412]" GO:0000463; GO:0003729; GO:0003735; GO:0006412; GO:0022625; GO:0043021; GO:0071493 0 0 cd00427; PF00831; P18433 CHOYP_PTPRK.11.20 m.34319 sp PTPRA_HUMAN 32.11 109 68 2 9 114 695 800 9.31E-13 66.2 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; P20072 CHOYP_LOC100561894.1.1 m.45814 sp ANXA7_BOVIN 53.552 366 152 4 238 593 104 461 9.31E-131 394 ANXA7_BOVIN reviewed Annexin A7 (Annexin VII) (Annexin-7) (Synexin) ANXA7 ANX7 Bos taurus (Bovine) 463 autophagy [GO:0006914]; cell proliferation [GO:0008283]; cellular calcium ion homeostasis [GO:0006874]; cellular water homeostasis [GO:0009992]; epithelial cell differentiation [GO:0030855]; hemostasis [GO:0007599]; negative regulation of gene expression [GO:0010629]; regulation of cell shape [GO:0008360]; response to salt stress [GO:0009651]; social behavior [GO:0035176] GO:0005509; GO:0005544; GO:0005635; GO:0005789; GO:0005829; GO:0005886; GO:0006874; GO:0006914; GO:0007599; GO:0008283; GO:0008360; GO:0009651; GO:0009992; GO:0010629; GO:0030855; GO:0035176; GO:0042584; GO:0042802; GO:0044822; GO:0048306; GO:0070062 0 0 0 PF00191; P24733 CHOYP_MYS.1.7 m.439 sp MYS_ARGIR 60.484 124 49 0 7 130 1316 1439 9.31E-40 145 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; P34147 CHOYP_LOC100179142.1.1 m.26403 sp RACA_DICDI 30.225 579 345 13 4 539 3 565 9.31E-68 233 RACA_DICDI reviewed Rho-related protein racA racA DDB_G0286555 Dictyostelium discoideum (Slime mold) 598 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0019901 0 0 0 PF00651;PF00071; P42674 CHOYP_LOC100371085.1.1 m.44789 sp BP10_PARLI 28.974 390 216 19 128 487 87 445 9.31E-24 110 BP10_PARLI reviewed Blastula protease 10 (EC 3.4.24.-) BP10 Paracentrotus lividus (Common sea urchin) 597 0 GO:0004222; GO:0005615; GO:0005938; GO:0008270; GO:0048471 0 0 0 PF01400;PF00431; P53810 CHOYP_PIPNA.1.1 m.37750 sp PIPNA_MOUSE 60.839 286 87 5 37 315 4 271 9.31E-121 350 PIPNA_MOUSE reviewed Phosphatidylinositol transfer protein alpha isoform (PI-TP-alpha) (PtdIns transfer protein alpha) (PtdInsTP alpha) Pitpna Pitpn Mus musculus (Mouse) 271 transport [GO:0006810] GO:0005543; GO:0005829; GO:0006810; GO:0008289; GO:0016021; GO:0043209; GO:0070062 0 0 0 PF02121; Q0P5A2 CHOYP_LOC585972.1.1 m.25356 sp COQ5_BOVIN 59.932 292 107 3 39 330 46 327 9.31E-122 356 COQ5_BOVIN reviewed "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5)" COQ5 Bos taurus (Bovine) 330 methylation [GO:0032259]; ubiquinone biosynthetic process [GO:0006744] GO:0005739; GO:0006744; GO:0008425; GO:0008757; GO:0031314; GO:0032259; GO:0102005 PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03191}. 0 0 PF01209; Q2VLG6 CHOYP_C163A.1.2 m.20046 sp C163A_CANLF 42.471 259 142 5 6 262 111 364 9.31E-61 216 C163A_CANLF reviewed Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)] CD163 M130 Canis lupus familiaris (Dog) (Canis familiaris) 1133 acute-phase response [GO:0006953] GO:0005044; GO:0005576; GO:0005886; GO:0006953; GO:0016021 0 0 0 PF00530; Q5HZL1 CHOYP_ERI2.1.1 m.16035 sp ERI2_XENLA 62.551 243 88 2 46 286 3 244 9.31E-106 338 ERI2_XENLA reviewed ERI1 exoribonuclease 2 (EC 3.1.-.-) (Exonuclease domain-containing protein 1) eri2 exod1 Xenopus laevis (African clawed frog) 687 0 GO:0003676; GO:0004527; GO:0008270 0 0 0 PF00929;PF06839; Q5PQJ7 CHOYP_BRAFLDRAFT_127100.2.2 m.42595 sp TBCEL_RAT 28.049 492 272 12 44 530 7 421 9.31E-47 172 TBCEL_RAT reviewed Tubulin-specific chaperone cofactor E-like protein (Leucine-rich repeat-containing protein 35) Tbcel Lrrc35 Rattus norvegicus (Rat) 424 0 GO:0005737; GO:0005856 0 0 0 PF14560; Q8IWZ3 CHOYP_LOC100197555.2.7 m.32624 sp ANKH1_HUMAN 31.92 448 276 17 347 774 212 650 9.31E-37 153 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8R003 CHOYP_DSEC_GM21767.1.1 m.63021 sp MBNL3_MOUSE 42.623 61 32 2 69 126 175 235 9.31E-08 52.8 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q8R003 CHOYP_DYAK_GE11656.1.2 m.34707 sp MBNL3_MOUSE 42.623 61 32 2 69 126 175 235 9.31E-08 52.8 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q8R003 CHOYP_DYAK_GE11656.2.2 m.54700 sp MBNL3_MOUSE 42.623 61 32 2 69 126 175 235 9.31E-08 52.8 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q8R003 CHOYP_LOC100142119.2.2 m.50758 sp MBNL3_MOUSE 42.623 61 32 2 69 126 175 235 9.31E-08 52.8 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q8R003 CHOYP_LOC100165326.1.1 m.45449 sp MBNL3_MOUSE 42.623 61 32 2 69 126 175 235 9.31E-08 52.8 MBNL3_MOUSE reviewed Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein MCHCR) Mbnl3 Chcr Mbxl Mus musculus (Mouse) 342 mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; negative regulation of myoblast differentiation [GO:0045662]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380] GO:0005634; GO:0005737; GO:0006397; GO:0007275; GO:0008380; GO:0043484; GO:0044822; GO:0045662; GO:0046872 0 0 0 0 Q9D5U8 CHOYP_LOC100893228.2.5 m.27867 sp CNBD2_MOUSE 27.586 232 151 3 85 305 163 388 9.31E-18 90.9 CNBD2_MOUSE reviewed Cyclic nucleotide-binding domain-containing protein 2 (Cyclic nucleotide receptor involved in sperm function) Cnbd2 Cris Mus musculus (Mouse) 673 spermatogenesis [GO:0007283] GO:0005829; GO:0007283; GO:0030552 0 0 0 PF00027; B4PEU8 CHOYP_SETD3.1.1 m.42584 sp RS9_DROYA 87.709 179 22 0 3 181 4 182 9.32E-111 317 RS9_DROYA reviewed 40S ribosomal protein S9 RpS9 GE21228 Drosophila yakuba (Fruit fly) 195 translation [GO:0006412] GO:0003735; GO:0006412; GO:0015935; GO:0019843 0 0 0 PF00163;PF01479; Q4LDE5 CHOYP_LOC100702634.1.1 m.14139 sp SVEP1_HUMAN 26.217 267 168 13 25 265 2264 2527 9.32E-12 68.6 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q6IQ20 CHOYP_LOC100371650.1.1 m.4398 sp NAPEP_HUMAN 43.182 352 171 11 11 356 62 390 9.32E-96 293 NAPEP_HUMAN reviewed N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) NAPEPLD C7orf18 Homo sapiens (Human) 393 phospholipid catabolic process [GO:0009395]; retinoid metabolic process [GO:0001523] GO:0001523; GO:0005737; GO:0008270; GO:0009395; GO:0042622; GO:0070062; GO:0070290 0 0 0 PF12706; Q6VEU1 CHOYP_SUDX.1.1 m.4578 sp NOB1_RAT 59.375 128 51 1 12 139 4 130 9.32E-44 154 NOB1_RAT reviewed RNA-binding protein NOB1 Nob1 Nob1p Rattus norvegicus (Rat) 410 cleavage involved in rRNA processing [GO:0000469]; maturation of SSU-rRNA [GO:0030490]; visual perception [GO:0007601] GO:0000469; GO:0004521; GO:0005634; GO:0007601; GO:0030490; GO:0030688; GO:0046872 0 0 0 PF08772;PF17146;PF15017; Q7TNV1 CHOYP_FA57B.1.3 m.6224 sp FA57B_MOUSE 50.45 111 55 0 8 118 150 260 9.32E-31 113 FA57B_MOUSE reviewed Protein FAM57B Fam57b Mus musculus (Mouse) 275 ceramide biosynthetic process [GO:0046513]; negative regulation of fat cell differentiation [GO:0045599] GO:0000139; GO:0005783; GO:0005789; GO:0005794; GO:0016021; GO:0045599; GO:0046513; GO:0050291 0 0 0 PF03798; Q810N6 CHOYP_LOC100185472.1.1 m.66178 sp ANR45_MOUSE 40.5 200 119 0 31 230 43 242 9.32E-49 163 ANR45_MOUSE reviewed Ankyrin repeat domain-containing protein 45 Ankrd45 Mus musculus (Mouse) 248 0 0 0 0 0 PF12796; Q8IT98 CHOYP_IF4A3.1.1 m.30426 sp RS18_ARGIR 78.723 94 20 0 1 94 27 120 9.32E-52 162 RS18_ARGIR reviewed 40S ribosomal protein S18 RPS18 Argopecten irradians (Bay scallop) (Aequipecten irradians) 152 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF00416; Q8IVU9 CHOYP_LOC592209.1.1 m.48009 sp CJ107_HUMAN 34.259 216 116 3 108 308 3 207 9.32E-32 120 CJ107_HUMAN reviewed Uncharacterized protein C10orf107 C10orf107 Homo sapiens (Human) 208 0 0 0 0 0 PF14769; Q9I8C7 CHOYP_NEMVEDRAFT_V1G205855.2.2 m.66388 sp ACH10_CHICK 31.858 226 149 2 6 226 10 235 9.32E-34 129 ACH10_CHICK reviewed Neuronal acetylcholine receptor subunit alpha-10 (Alpha 10 nAChR) (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10) CHRNA10 Gallus gallus (Chicken) 452 "signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005892; GO:0007165; GO:0007271; GO:0030054; GO:0042166; GO:0045211 0 0 0 PF02931;PF02932; O13666 CHOYP_LOC100175543.1.1 m.9503 sp ERG32_SCHPO 31.447 159 93 5 100 258 79 221 9.33E-12 68.6 ERG32_SCHPO reviewed "Delta(7)-sterol 5(6)-desaturase erg32 (EC 1.14.19.20) (C-5 sterol desaturase erg32) (Ergosterol Delta(5,6) desaturase erg32) (Ergosterol biosynthesis protein 32) (Sterol-C5-desaturase erg32)" erg32 pi075 SPBC27B12.03c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 329 ergosterol biosynthetic process [GO:0006696]; fatty acid biosynthetic process [GO:0006633] GO:0000139; GO:0005506; GO:0005783; GO:0005794; GO:0006633; GO:0006696; GO:0016491; GO:0030176 PATHWAY: Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 3/5. 0 0 PF04116; O75179 CHOYP_LOC753709.29.44 m.52238 sp ANR17_HUMAN 36.389 360 215 11 21 369 303 659 9.33E-50 183 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P14841 CHOYP_CYT5.1.1 m.29962 sp CYTC_RAT 30.208 96 63 2 3 95 35 129 9.33E-06 44.7 CYTC_RAT reviewed Cystatin-C (Cystatin-3) Cst3 Rattus norvegicus (Rat) 140 "apoptotic process [GO:0006915]; brain development [GO:0007420]; cell activation [GO:0001775]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to oxidative stress [GO:0034599]; circadian sleep/wake cycle, REM sleep [GO:0042747]; embryo implantation [GO:0007566]; eye development [GO:0001654]; male gonad development [GO:0008584]; negative regulation of cell death [GO:0060548]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; regulation of programmed cell death [GO:0043067]; response to axon injury [GO:0048678]; response to carbohydrate [GO:0009743]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to inorganic substance [GO:0010035]; response to nutrient levels [GO:0031667]; response to organic cyclic compound [GO:0014070]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; salivary gland development [GO:0007431]; Sertoli cell development [GO:0060009]" GO:0001654; GO:0001666; GO:0001775; GO:0002020; GO:0004869; GO:0005604; GO:0005615; GO:0005737; GO:0005764; GO:0005771; GO:0005783; GO:0006915; GO:0006979; GO:0007420; GO:0007431; GO:0007566; GO:0008284; GO:0008584; GO:0009636; GO:0009743; GO:0010035; GO:0014070; GO:0030414; GO:0030424; GO:0031667; GO:0031965; GO:0031982; GO:0032355; GO:0034599; GO:0042493; GO:0042747; GO:0042995; GO:0043025; GO:0043067; GO:0043292; GO:0045740; GO:0048471; GO:0048678; GO:0060009; GO:0060548; GO:0070301 0 0 0 PF00031; P26221 CHOYP_BRAFLDRAFT_118867.1.1 m.27944 sp GUN4_THEFU 49.775 444 195 8 151 573 50 486 9.33E-123 385 GUN4_THEFU reviewed "Endoglucanase E-4 (EC 3.2.1.4) (Cellulase E-4) (Cellulase E4) (Endo-1,4-beta-glucanase E-4)" celD Thermobifida fusca (Thermomonospora fusca) 880 cellulose catabolic process [GO:0030245] GO:0008810; GO:0030245; GO:0030248 PATHWAY: Glycan metabolism; cellulose degradation. 0 0 PF00553;PF00942;PF00041;PF00759; P78504 CHOYP_DLL1.1.1 m.4589 sp JAG1_HUMAN 26.415 583 331 23 32 567 37 568 9.33E-31 131 JAG1_HUMAN reviewed Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) JAG1 JAGL1 Homo sapiens (Human) 1218 angiogenesis [GO:0001525]; aorta morphogenesis [GO:0035909]; auditory receptor cell differentiation [GO:0042491]; blood vessel remodeling [GO:0001974]; cardiac neural crest cell development involved in outflow tract morphogenesis [GO:0061309]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac septum morphogenesis [GO:0060411]; cell fate determination [GO:0001709]; ciliary body morphogenesis [GO:0061073]; distal tubule development [GO:0072017]; endocardial cushion cell development [GO:0061444]; endothelial cell differentiation [GO:0045446]; glomerular visceral epithelial cell development [GO:0072015]; hemopoiesis [GO:0030097]; keratinocyte differentiation [GO:0030216]; loop of Henle development [GO:0072070]; morphogenesis of an epithelial sheet [GO:0002011]; myoblast differentiation [GO:0045445]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of stem cell differentiation [GO:2000737]; nephron development [GO:0072006]; nervous system development [GO:0007399]; neuronal stem cell population maintenance [GO:0097150]; Notch receptor processing [GO:0007220]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; positive regulation of myeloid cell differentiation [GO:0045639]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; regulation of cell migration [GO:0030334]; regulation of cell proliferation [GO:0042127]; response to muramyl dipeptide [GO:0032495]; T cell mediated immunity [GO:0002456] GO:0001525; GO:0001709; GO:0001974; GO:0002011; GO:0002456; GO:0003184; GO:0003215; GO:0005112; GO:0005198; GO:0005509; GO:0005576; GO:0005886; GO:0005887; GO:0005912; GO:0007219; GO:0007220; GO:0007399; GO:0008083; GO:0016020; GO:0016324; GO:0030097; GO:0030216; GO:0030334; GO:0032495; GO:0035909; GO:0042127; GO:0042491; GO:0045445; GO:0045446; GO:0045599; GO:0045639; GO:0045665; GO:0045669; GO:0045747; GO:0045944; GO:0060411; GO:0061073; GO:0061156; GO:0061309; GO:0061314; GO:0061444; GO:0072006; GO:0072015; GO:0072017; GO:0072070; GO:0097150; GO:2000737 0 0 0 PF01414;PF00008;PF07645;PF12661;PF07657; P83741 CHOYP_LOC578600.1.1 m.45849 sp WNK1_MOUSE 68.966 377 112 3 274 648 192 565 9.33E-164 563 WNK1_MOUSE reviewed Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) Wnk1 Hsn2 Prkwnk1 Mus musculus (Mouse) 2377 intracellular signal transduction [GO:0035556]; ion transport [GO:0006811]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of phosphatase activity [GO:0010923]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of systemic arterial blood pressure [GO:0003084]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cellular process [GO:0050794]; regulation of ion homeostasis [GO:2000021] GO:0000287; GO:0003084; GO:0004672; GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0006811; GO:0010923; GO:0019869; GO:0019870; GO:0019902; GO:0030291; GO:0032414; GO:0035556; GO:0046777; GO:0050794; GO:0090188; GO:2000021 0 0 0 PF12202;PF00069; Q05192 CHOYP_PHUM_PHUM318510.1.1 m.52099 sp FTF1B_DROME 42 200 113 2 436 635 611 807 9.33E-47 180 FTF1B_DROME reviewed Nuclear hormone receptor FTZ-F1 beta (Nuclear hormone receptor HR39) (dHR39) (Nuclear receptor subfamily 5 group B member 1) Hr39 FTZ-F1-beta FTZF1-beta NR5-beta-1 NR5B1 CG8676 Drosophila melanogaster (Fruit fly) 808 "female meiosis chromosome segregation [GO:0016321]; hormone-mediated signaling pathway [GO:0009755]; male courtship behavior, veined wing generated song production [GO:0045433]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of gene silencing [GO:0060968]; regulation of glucose metabolic process [GO:0010906]; regulation of transcription, DNA-templated [GO:0006355]; spermathecum morphogenesis [GO:0035211]; tissue development [GO:0009888]; transcription, DNA-templated [GO:0006351]" GO:0000978; GO:0003682; GO:0003707; GO:0004879; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0009755; GO:0009888; GO:0010906; GO:0016321; GO:0035211; GO:0045433; GO:0045944; GO:0060968; GO:0090575 0 0 0 PF00104;PF00105; Q6ZRF8 CHOYP_LOC100374741.7.83 m.3758 sp RN207_HUMAN 23.445 209 137 9 4 206 103 294 9.33E-09 61.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q8ISN9 CHOYP_LOC101157312.1.1 m.5455 sp RS25_BRABE 76.744 86 20 0 53 138 28 113 9.33E-35 120 RS25_BRABE reviewed 40S ribosomal protein S25 RPS25 Branchiostoma belcheri (Amphioxus) 123 0 GO:0005840 0 0 0 PF03297; Q8VHI5 CHOYP_LOC100636433.2.4 m.5712 sp VITRN_MOUSE 34.831 178 113 2 178 355 467 641 9.33E-26 116 VITRN_MOUSE reviewed Vitrin Vit Mus musculus (Mouse) 650 extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811] GO:0005539; GO:0005578; GO:0005614; GO:0010811; GO:0030198 0 0 0 PF03815;PF00092; Q91ZA3 CHOYP_CLK2.1.1 m.3082 sp PCCA_MOUSE 74.744 293 74 0 48 340 51 343 9.33E-156 457 PCCA_MOUSE reviewed "Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)" Pcca Mus musculus (Mouse) 724 0 GO:0004075; GO:0004658; GO:0005524; GO:0005739; GO:0005759; GO:0019899; GO:0046872 PATHWAY: Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 1/3. 0 0 PF02785;PF00289;PF00364;PF02786; Q9DB94 CHOYP_NEMVEDRAFT_V1G244670.1.1 m.14346 sp WDR53_MOUSE 31.18 356 228 10 6 348 5 356 9.33E-48 167 WDR53_MOUSE reviewed WD repeat-containing protein 53 Wdr53 Mus musculus (Mouse) 358 0 0 0 0 0 PF00400; Q9NZJ4 CHOYP_BRAFLDRAFT_118535.6.8 m.55199 sp SACS_HUMAN 23.301 2678 1701 88 23 2471 2004 4557 9.33E-145 511 SACS_HUMAN reviewed Sacsin (DnaJ homolog subfamily C member 29) (DNAJC29) SACS KIAA0730 Homo sapiens (Human) 4579 negative regulation of inclusion body assembly [GO:0090084]; protein folding [GO:0006457] GO:0005634; GO:0005737; GO:0005739; GO:0006457; GO:0030424; GO:0030425; GO:0030544; GO:0051087; GO:0070628; GO:0070852; GO:0090084 0 0 0 PF05168;PF00240; Q9NZN5 CHOYP_LOC100644321.5.7 m.44981 sp ARHGC_HUMAN 43.702 389 201 8 802 1175 755 1140 9.33E-80 295 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q9Y5Z4 CHOYP_BRAFLDRAFT_261932.1.1 m.23690 sp HEBP2_HUMAN 47.205 161 85 0 30 190 37 197 9.33E-49 160 HEBP2_HUMAN reviewed Heme-binding protein 2 (Placental protein 23) (PP23) (Protein SOUL) HEBP2 C6orf34 SOUL Homo sapiens (Human) 205 negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of mitochondrial membrane permeability [GO:0035794]; positive regulation of necrotic cell death [GO:0010940] GO:0005737; GO:0005739; GO:0010917; GO:0010940; GO:0035794; GO:0070062 0 0 0 PF04832; E7FDB3 CHOYP_LOC100313663.1.1 m.14947 sp NANO1_DANRE 52.128 94 42 1 134 227 136 226 9.34E-26 103 NANO1_DANRE reviewed Nanos homolog 1 nanos1 wu:fb76c12 Danio rerio (Zebrafish) (Brachydanio rerio) 228 germ cell development [GO:0007281]; germ cell migration [GO:0008354] GO:0003723; GO:0005737; GO:0007281; GO:0008270; GO:0008354; GO:0030371; GO:0048471; GO:0060293 0 0 0 PF05741; P17126 CHOYP_ACT3.3.3 m.66908 sp ACT_HYDVU 98.701 154 2 0 12 165 40 193 9.34E-110 322 ACT_HYDVU reviewed "Actin, non-muscle 6.2" 0 Hydra vulgaris (Hydra) (Hydra attenuata) 376 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q2Y0W8 CHOYP_S4A7.1.1 m.12135 sp S4A8_HUMAN 65.179 224 73 2 21 242 288 508 9.34E-95 303 S4A8_HUMAN reviewed Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na(+)-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) SLC4A8 KIAA0739 NBC NBC3 NDCBE1 Homo sapiens (Human) 1093 anion transmembrane transport [GO:0098656]; bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005452; GO:0005886; GO:0005887; GO:0006814; GO:0008509; GO:0015301; GO:0015701; GO:0032809; GO:0043005; GO:0051453; GO:0098656 0 0 0 PF07565;PF00955; Q3UK37 CHOYP_LOC100717056.1.1 m.58974 sp CN080_MOUSE 31.058 293 183 6 42 334 33 306 9.34E-25 109 CN080_MOUSE reviewed Uncharacterized protein C14orf80 homolog 0 Mus musculus (Mouse) 420 0 0 0 0 0 PF14970;PF14971; Q8TF66 CHOYP_BRAFLDRAFT_88473.1.1 m.20882 sp LRC15_HUMAN 35.323 201 127 1 1 198 265 465 9.34E-30 121 LRC15_HUMAN reviewed Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib) LRRC15 LIB Homo sapiens (Human) 581 cytokine-mediated signaling pathway [GO:0019221]; negative regulation of establishment of protein localization to plasma membrane [GO:0090005]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of cell migration [GO:0030335]; receptor-mediated virion attachment to host cell [GO:0046813] GO:0001968; GO:0004860; GO:0005518; GO:0005737; GO:0006469; GO:0016021; GO:0019221; GO:0030335; GO:0043236; GO:0046426; GO:0046813; GO:0070062; GO:0090005 0 0 0 PF00560;PF13855; Q98925 CHOYP_IRF2.1.2 m.36261 sp IRF2_CHICK 47.414 116 57 2 19 130 2 117 9.34E-30 113 IRF2_CHICK reviewed Interferon regulatory factor 2 (IRF-2) IRF2 Gallus gallus (Chicken) 348 cell proliferation [GO:0008283] GO:0000977; GO:0001228; GO:0005654; GO:0005737; GO:0005925; GO:0008283 0 0 0 PF00605; Q9BRZ2 CHOYP_TIF1A.3.8 m.12841 sp TRI56_HUMAN 21.531 209 135 6 19 210 17 213 9.34E-10 61.2 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9UKG1 CHOYP_DP13A.3.3 m.39155 sp DP13A_HUMAN 40.941 723 390 11 2 711 3 701 9.34E-179 531 DP13A_HUMAN reviewed "DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)" APPL1 APPL DIP13A KIAA1428 Homo sapiens (Human) 709 cell cycle [GO:0007049]; cell proliferation [GO:0008283]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; insulin receptor signaling pathway [GO:0008286]; regulation of establishment of protein localization to plasma membrane [GO:0090003]; regulation of glucose import [GO:0046324]; signal transduction [GO:0007165] GO:0005634; GO:0005737; GO:0005829; GO:0007049; GO:0007165; GO:0008283; GO:0008286; GO:0010008; GO:0012506; GO:0031901; GO:0042802; GO:0043422; GO:0046324; GO:0070062; GO:0090003; GO:0097192 0 0 0 PF00169;PF00640; Q9ULI1 CHOYP_LOC100378314.3.3 m.29778 sp NWD2_HUMAN 30.034 586 345 19 1 538 452 1020 9.34E-53 207 NWD2_HUMAN reviewed NACHT and WD repeat domain-containing protein 2 (Leucine-rich repeat and WD repeat-containing protein KIAA1239) NWD2 KIAA1239 Homo sapiens (Human) 1742 0 0 0 0 0 PF13271; O97827 CHOYP_LOC100889522.2.2 m.39508 sp AGRL3_BOVIN 30.612 98 67 1 774 871 938 1034 9.35E-07 56.6 AGRL3_BOVIN reviewed Adhesion G protein-coupled receptor L3 (Latrophilin-3) ADGRL3 LPH3 LPHN3 Bos taurus (Bovine) 1580 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; neuron migration [GO:0001764]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007416; GO:0030246; GO:0030424; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; P14133 CHOYP_LOC100198324.2.6 m.33990 sp ASO_CUCSA 28.188 596 299 21 100 660 58 559 9.35E-44 169 ASO_CUCSA reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) 0 Cucumis sativus (Cucumber) 587 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; P16157 CHOYP_LOC755521.9.28 m.36934 sp ANK1_HUMAN 31.852 405 256 3 31 434 207 592 9.35E-51 188 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18445 CHOYP_LOC100533291.4.7 m.29195 sp RL27A_RAT 75.735 136 32 1 1 135 1 136 9.35E-72 223 RL27A_RAT reviewed 60S ribosomal protein L27a Rpl27a Rattus norvegicus (Rat) 148 translation [GO:0006412] GO:0003735; GO:0006412; GO:0022625 0 0 0 PF00828; Q2KJ63 CHOYP_BRAFLDRAFT_123740.1.1 m.30162 sp KLKB1_BOVIN 39.095 243 135 9 104 337 389 627 9.35E-46 167 KLKB1_BOVIN reviewed Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] KLKB1 Bos taurus (Bovine) 636 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; inflammatory response [GO:0006954]; plasminogen activation [GO:0031639]; positive regulation of fibrinolysis [GO:0051919] GO:0004252; GO:0005615; GO:0006954; GO:0007596; GO:0031639; GO:0042730; GO:0042803; GO:0051919; GO:0070062 0 0 cd00190; PF00024;PF14295;PF00089; Q40588 CHOYP_LOC100376857.4.7 m.47467 sp ASO_TOBAC 27.778 612 321 21 45 625 45 566 9.35E-52 193 ASO_TOBAC reviewed L-ascorbate oxidase (ASO) (Ascorbase) (EC 1.10.3.3) AAO Nicotiana tabacum (Common tobacco) 578 0 GO:0005507; GO:0005576; GO:0008447 0 0 0 PF00394;PF07731;PF07732; Q4UMH6 CHOYP_TNI3K.1.2 m.22943 sp Y381_RICFE 26.667 390 215 14 328 702 789 1122 9.35E-19 95.1 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q53FA7 CHOYP_BRAFLDRAFT_57258.1.3 m.43522 sp QORX_HUMAN 66.129 124 42 0 3 126 31 154 9.35E-50 164 QORX_HUMAN reviewed Quinone oxidoreductase PIG3 (EC 1.-.-.-) (Tumor protein p53-inducible protein 3) (p53-induced gene 3 protein) TP53I3 PIG3 Homo sapiens (Human) 332 NADP metabolic process [GO:0006739]; regulation of apoptotic process [GO:0042981] GO:0003960; GO:0005829; GO:0006739; GO:0008270; GO:0042803; GO:0042981; GO:0048038; GO:0070062; GO:0070402 0 0 0 PF08240;PF00107; Q8JZR6 CHOYP_S4A10.1.4 m.1268 sp S4A8_MOUSE 50.649 462 184 6 2 462 204 622 9.35E-148 452 S4A8_MOUSE reviewed Electroneutral sodium bicarbonate exchanger 1 (Electroneutral Na+-driven Cl-HCO3 exchanger) (Solute carrier family 4 member 8) (k-NBC3) Slc4a8 Kiaa0739 Mus musculus (Mouse) 1089 anion transmembrane transport [GO:0098656]; bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814] GO:0005452; GO:0005886; GO:0005887; GO:0006814; GO:0008509; GO:0015301; GO:0015701; GO:0016020; GO:0032809; GO:0043005; GO:0051453; GO:0098656 0 0 0 PF07565;PF00955; Q8K0U4 CHOYP_BRAFLDRAFT_57788.9.10 m.50109 sp HS12A_MOUSE 31.169 462 230 15 310 700 57 501 9.35E-54 199 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208436.12.32 m.43392 sp HS12B_HUMAN 31.329 632 340 15 10 566 61 673 9.35E-95 306 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 O60610 CHOYP_LOC100741633.1.1 m.25529 sp DIAP1_HUMAN 32.974 649 391 13 18 652 56 674 9.36E-89 304 DIAP1_HUMAN reviewed Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) DIAPH1 DIAP1 Homo sapiens (Human) 1272 actin filament polymerization [GO:0030041]; cellular response to histamine [GO:0071420]; cytoskeleton organization [GO:0007010]; positive regulation of cell migration [GO:0030335]; protein localization to microtubule [GO:0035372]; regulation of cell motility [GO:2000145]; regulation of cell shape [GO:0008360]; regulation of microtubule-based process [GO:0032886]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; sensory perception of sound [GO:0007605] GO:0005102; GO:0005815; GO:0005829; GO:0007010; GO:0007605; GO:0008360; GO:0030041; GO:0030335; GO:0032587; GO:0032886; GO:0035372; GO:0044325; GO:0044822; GO:0051279; GO:0071420; GO:0072686; GO:2000145 0 0 0 PF06345;PF06346;PF06367;PF06371;PF02181; O75179 CHOYP_LOC762964.9.10 m.55520 sp ANR17_HUMAN 30.699 544 290 14 777 1297 238 717 9.36E-50 198 ANR17_HUMAN reviewed Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16) ANKRD17 GTAR KIAA0697 Homo sapiens (Human) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275]; viral process [GO:0016032] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0016020; GO:0016032; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; P02693 CHOYP_LOC100566943.1.2 m.35349 sp FABPI_RAT 37.037 135 73 3 8 136 3 131 9.36E-14 66.6 FABPI_RAT reviewed "Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)" Fabp2 Fabpi Rattus norvegicus (Rat) 132 fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; intestinal absorption [GO:0050892]; long-chain fatty acid transport [GO:0015909] GO:0005324; GO:0005504; GO:0005737; GO:0005886; GO:0005902; GO:0006631; GO:0015908; GO:0015909; GO:0045179; GO:0050892 0 0 0 PF00061; P10079 CHOYP_LOC575027.2.6 m.31563 sp FBP1_STRPU 54.654 419 188 2 110 528 330 746 9.36E-144 456 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P14318 CHOYP_SMP_078690.4.5 m.41581 sp MP20_DROME 39.267 191 104 4 8 197 1 180 9.36E-37 130 MP20_DROME reviewed Muscle-specific protein 20 Mp20 Tpn CG4696 Drosophila melanogaster (Fruit fly) 184 cell adhesion [GO:0007155]; myoblast fusion [GO:0007520]; regulation of cell shape [GO:0008360]; regulation of myoblast fusion [GO:1901739] GO:0003779; GO:0007155; GO:0007520; GO:0008360; GO:1901739 0 0 0 PF00402;PF00307; Q29497 CHOYP_LOC100553634.1.1 m.65820 sp CP17A_SHEEP 29.903 515 327 12 1 496 1 500 9.36E-59 205 CP17A_SHEEP reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Ovis aries (Sheep) 509 hormone biosynthetic process [GO:0042446]; progesterone metabolic process [GO:0042448]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0008202; GO:0016020; GO:0020037; GO:0042446; GO:0042448; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; Q6ZR37 CHOYP_LOC577927.1.1 m.62185 sp PKHG7_HUMAN 34.626 361 218 5 410 759 3 356 9.36E-63 218 PKHG7_HUMAN reviewed Pleckstrin homology domain-containing family G member 7 (PH domain-containing family G member 7) PLEKHG7 Homo sapiens (Human) 379 regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0035023 0 0 0 PF00621; Q9HAR2 CHOYP_LPHN3.4.4 m.50946 sp AGRL3_HUMAN 26.568 271 187 6 907 1175 852 1112 9.36E-21 103 AGRL3_HUMAN reviewed Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3) ADGRL3 KIAA0768 LEC3 LPHN3 Homo sapiens (Human) 1447 cell-cell adhesion [GO:0098609]; cell surface receptor signaling pathway [GO:0007166]; G-protein coupled receptor signaling pathway [GO:0007186]; locomotion involved in locomotory behavior [GO:0031987]; neuron migration [GO:0001764]; positive regulation of synapse assembly [GO:0051965]; response to cocaine [GO:0042220]; synapse assembly [GO:0007416] GO:0001764; GO:0004930; GO:0005509; GO:0005887; GO:0005911; GO:0007166; GO:0007186; GO:0007416; GO:0016021; GO:0030246; GO:0030424; GO:0031987; GO:0042220; GO:0051965; GO:0098609 0 0 0 PF00002;PF16489;PF02140;PF01825;PF02793;PF02354;PF02191; Q9UGM3 CHOYP_DMBT1.11.34 m.22620 sp DMBT1_HUMAN 36.637 565 251 15 274 745 363 913 9.36E-82 293 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q9VCA8 CHOYP_LOC100637968.10.12 m.51491 sp ANKHM_DROME 33.119 311 188 11 1 292 571 880 9.36E-35 137 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; O01393 CHOYP_LOC100533355.1.2 m.6485 sp UNC9_CAEEL 40 360 208 3 21 380 20 371 9.37E-95 292 UNC9_CAEEL reviewed Innexin unc-9 (Uncoordinated protein 9) unc-9 R12H7.1 Caenorhabditis elegans 386 ion transmembrane transport [GO:0034220] GO:0005243; GO:0005886; GO:0005911; GO:0005921; GO:0016021; GO:0034220; GO:0055077 0 0 0 PF00876; P10079 CHOYP_LOC100634060.17.37 m.38428 sp FBP1_STRPU 53.623 276 128 0 2 277 290 565 9.37E-84 274 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P18052 CHOYP_PTPRT.38.45 m.60045 sp PTPRA_MOUSE 31.731 104 70 1 11 113 724 827 9.37E-13 66.2 PTPRA_MOUSE reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) (LCA-related phosphatase) (PTPTY-28) Ptpra Lrp Ptpa Mus musculus (Mouse) 829 insulin receptor signaling pathway [GO:0008286]; protein phosphorylation [GO:0006468] GO:0004725; GO:0006468; GO:0008286; GO:0016021; GO:0043235; GO:0070062 0 0 0 PF00102; P25789 CHOYP_PSA4.1.1 m.19303 sp PSA4_HUMAN 84.388 237 37 0 1 237 1 237 9.37E-152 426 PSA4_HUMAN reviewed Proteasome subunit alpha type-4 (EC 3.4.25.1) (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) PSMA4 HC9 PSC9 Homo sapiens (Human) 261 "anaphase-promoting complex-dependent catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; Fc-epsilon receptor signaling pathway [GO:0038095]; MAPK cascade [GO:0000165]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of mRNA stability [GO:0043488]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; viral process [GO:0016032]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]" GO:0000165; GO:0000209; GO:0000502; GO:0000932; GO:0002223; GO:0002479; GO:0004298; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005839; GO:0006521; GO:0016032; GO:0019773; GO:0031145; GO:0033209; GO:0038061; GO:0038095; GO:0043161; GO:0043231; GO:0043488; GO:0050852; GO:0051436; GO:0051437; GO:0060071; GO:0070062; GO:0090090; GO:0090263 0 0 0 PF00227;PF10584; Q26636 CHOYP_LOC575203.5.6 m.19652 sp CATL_SARPE 53.517 327 143 4 10 329 15 339 9.37E-125 363 CATL_SARPE reviewed Cathepsin L (EC 3.4.22.15) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] 0 Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina) 339 cell differentiation [GO:0030154]; multicellular organism development [GO:0007275] GO:0005764; GO:0007275; GO:0008234; GO:0030154 0 0 0 PF08246;PF00112; Q5VU97 CHOYP_NEMVEDRAFT_V1G239644.3.4 m.41275 sp CAHD1_HUMAN 26.321 1022 664 35 1 959 124 1119 9.37E-83 296 CAHD1_HUMAN reviewed VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1) CACHD1 KIAA1573 VWCD1 Homo sapiens (Human) 1274 calcium ion transport [GO:0006816] GO:0006816; GO:0016021 0 0 0 PF00092;PF08399; Q61080 CHOYP_FOXF1.1.1 m.4194 sp FOXF1_MOUSE 69.101 178 44 4 64 240 33 200 9.37E-64 211 FOXF1_MOUSE reviewed Forkhead box protein F1 (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1) (FREAC-1) (Hepatocyte nuclear factor 3 forkhead homolog 8) (HFH-8) Foxf1 Fkhl5 Foxf1a Freac1 Hfh8 Mus musculus (Mouse) 378 "blood vessel development [GO:0001568]; branching involved in open tracheal system development [GO:0060446]; cardiac left ventricle morphogenesis [GO:0003214]; cellular response to cytokine stimulus [GO:0071345]; cellular response to organic cyclic compound [GO:0071407]; detection of wounding [GO:0014822]; determination of left/right symmetry [GO:0007368]; digestive tract development [GO:0048565]; ductus arteriosus closure [GO:0097070]; embryonic digestive tract development [GO:0048566]; embryonic digestive tract morphogenesis [GO:0048557]; embryonic ectodermal digestive tract morphogenesis [GO:0048613]; embryonic foregut morphogenesis [GO:0048617]; endocardial cushion development [GO:0003197]; epithelial cell differentiation involved in mammary gland alveolus development [GO:0061030]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; establishment of epithelial cell apical/basal polarity [GO:0045198]; extracellular matrix organization [GO:0030198]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lateral mesodermal cell differentiation [GO:0048371]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung lobe morphogenesis [GO:0060463]; lung morphogenesis [GO:0060425]; lung vasculature development [GO:0060426]; mesenchyme migration [GO:0090131]; mesoderm development [GO:0007498]; midgut development [GO:0007494]; morphogenesis of a branching structure [GO:0001763]; negative regulation of inflammatory response [GO:0050728]; negative regulation of mast cell degranulation [GO:0043305]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; organ morphogenesis [GO:0009887]; pancreas development [GO:0031016]; positive regulation of cell migration [GO:0030335]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of smooth muscle cell differentiation [GO:0051150]; renal system development [GO:0072001]; respiratory tube development [GO:0030323]; right lung morphogenesis [GO:0060461]; single organismal cell-cell adhesion [GO:0016337]; smoothened signaling pathway [GO:0007224]; smooth muscle cell differentiation [GO:0051145]; somitogenesis [GO:0001756]; trachea development [GO:0060438]; ureter development [GO:0072189]; vasculogenesis [GO:0001570]; venous blood vessel development [GO:0060841]" GO:0000122; GO:0000977; GO:0001228; GO:0001568; GO:0001570; GO:0001701; GO:0001756; GO:0001763; GO:0002053; GO:0003197; GO:0003214; GO:0003677; GO:0003705; GO:0005634; GO:0007224; GO:0007368; GO:0007494; GO:0007498; GO:0007507; GO:0009887; GO:0010811; GO:0014822; GO:0016337; GO:0030198; GO:0030323; GO:0030324; GO:0030335; GO:0031016; GO:0043305; GO:0044212; GO:0045198; GO:0045893; GO:0045944; GO:0048286; GO:0048371; GO:0048557; GO:0048565; GO:0048566; GO:0048613; GO:0048617; GO:0050728; GO:0051145; GO:0051150; GO:0060425; GO:0060426; GO:0060438; GO:0060441; GO:0060446; GO:0060461; GO:0060463; GO:0060841; GO:0061030; GO:0071345; GO:0071407; GO:0072001; GO:0072189; GO:0090131; GO:0097070 0 0 0 PF00250; Q62210 CHOYP_TB10.389.1250.1.1 m.22390 sp BIRC2_MOUSE 41.176 51 30 0 290 340 560 610 9.37E-08 57 BIRC2_MOUSE reviewed Baculoviral IAP repeat-containing protein 2 (EC 6.3.2.-) (Cellular inhibitor of apoptosis 1) (C-IAP1) (Inhibitor of apoptosis protein 2) (mIAP2) Birc2 Mus musculus (Mouse) 612 "inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; necroptotic process [GO:0070266]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; negative regulation of ripoptosome assembly involved in necroptotic process [GO:1902443]; placenta development [GO:0001890]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein K48-linked ubiquitination [GO:1902524]; positive regulation of protein K63-linked ubiquitination [GO:1902523]; positive regulation of protein monoubiquitination [GO:1902527]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein heterooligomerization [GO:0051291]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; regulation of cell differentiation [GO:0045595]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of reactive oxygen species metabolic process [GO:2000377]; regulation of toll-like receptor signaling pathway [GO:0034121]; regulation of transcription, DNA-templated [GO:0006355]; response to cAMP [GO:0051591]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; transcription, DNA-templated [GO:0006351]" GO:0000209; GO:0001666; GO:0001741; GO:0001890; GO:0003713; GO:0004842; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0008270; GO:0009898; GO:0016740; GO:0016874; GO:0034121; GO:0035631; GO:0042981; GO:0043027; GO:0043066; GO:0043123; GO:0043161; GO:0045121; GO:0045471; GO:0045595; GO:0047485; GO:0050727; GO:0051291; GO:0051591; GO:0051726; GO:0060544; GO:0060546; GO:0070266; GO:1902443; GO:1902523; GO:1902524; GO:1902527; GO:1990001; GO:2000377 0 0 0 PF00653;PF00619; Q80U87 CHOYP_SELMODRAFT_2432.1.1 m.60719 sp UBP8_MOUSE 24.928 345 180 11 136 443 740 1042 9.37E-17 87.4 UBP8_MOUSE reviewed Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (mUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) Usp8 Kiaa0055 Ubpy Mus musculus (Mouse) 1080 endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000281; GO:0004843; GO:0005622; GO:0005654; GO:0005737; GO:0005769; GO:0005794; GO:0005829; GO:0006511; GO:0007032; GO:0007265; GO:0016579; GO:0019897; GO:0030496; GO:0031313; GO:0070536; GO:0071108 0 0 0 PF00581;PF00443;PF08969; Q86W50 CHOYP_LOC100561572.1.1 m.16499 sp MET16_HUMAN 38.584 565 297 13 1 525 1 555 9.37E-121 369 MET16_HUMAN reviewed Methyltransferase-like protein 16 (EC 2.1.1.-) (Methyltransferase 10 domain-containing protein) METTL16 METT10D Homo sapiens (Human) 562 rRNA base methylation [GO:0070475] GO:0005634; GO:0044822; GO:0052907; GO:0070475 0 0 0 PF05971; Q99996 CHOYP_LOC582174.3.16 m.20480 sp AKAP9_HUMAN 42.424 198 108 3 12 207 3587 3780 9.37E-33 128 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9CZJ2 CHOYP_HS12A.8.33 m.35601 sp HS12B_MOUSE 35.601 632 338 15 5 576 61 683 9.37E-119 369 HS12B_MOUSE reviewed Heat shock 70 kDa protein 12B Hspa12b Mus musculus (Mouse) 685 0 GO:0005524 0 0 0 0 Q9NL98 CHOYP_ISCW_ISCW010532.1.4 m.11493 sp PRDX_ASCSU 74.359 195 50 0 44 238 1 195 9.37E-109 314 PRDX_ASCSU reviewed Peroxiredoxin (EC 1.11.1.15) (AsPrx) (Thioredoxin peroxidase) 0 Ascaris suum (Pig roundworm) (Ascaris lumbricoides) 195 cell redox homeostasis [GO:0045454]; response to oxidative stress [GO:0006979] GO:0004601; GO:0005737; GO:0006979; GO:0008379; GO:0016209; GO:0045454 0 0 0 PF10417;PF00578; C7G0B5 CHOYP_LOC100929764.1.1 m.10208 sp PIF_PINFU 26.056 284 186 4 7 269 29 309 9.38E-28 117 PIF_PINFU reviewed Protein PIF [Cleaved into: Protein Pif97; Protein Pif80 (Aragonite-binding protein)] 0 Pinctada fucata (Akoya pearl oyster) (Pinctada imbricata fucata) 1007 chitin metabolic process [GO:0006030] GO:0005578; GO:0006030; GO:0008061 0 0 0 PF00092; O08585 CHOYP_SLK.1.1 m.59384 sp CLCA_MOUSE 45.662 219 82 5 10 202 28 235 9.38E-57 182 CLCA_MOUSE reviewed Clathrin light chain A (Lca) Clta Mus musculus (Mouse) 235 clathrin-mediated endocytosis [GO:0072583]; intracellular protein transport [GO:0006886] GO:0005198; GO:0006886; GO:0016020; GO:0016023; GO:0030125; GO:0030130; GO:0030132; GO:0032050; GO:0043231; GO:0071439; GO:0072583 0 0 0 PF01086; Q5ND28 CHOYP_LOC100547900.1.1 m.24503 sp SREC_MOUSE 33.645 107 67 3 187 293 152 254 9.38E-11 66.2 SREC_MOUSE reviewed Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1 protein) (SREC-I) Scarf1 Kiaa0149 Srec Mus musculus (Mouse) 820 cell adhesion [GO:0007155]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898] GO:0005044; GO:0005886; GO:0006898; GO:0007155; GO:0010976; GO:0016021; GO:0016322; GO:0016358; GO:0030169; GO:0048680 0 0 0 PF00053; Q5U5C5 CHOYP_PRP31.2.6 m.5244 sp PRP31_XENLA 73.494 166 44 0 23 188 324 489 9.38E-70 223 PRP31_XENLA reviewed U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) prpf31 Xenopus laevis (African clawed frog) 498 spliceosomal tri-snRNP complex assembly [GO:0000244] GO:0000244; GO:0003723; GO:0005681; GO:0046540; GO:0071339 0 0 0 PF01798;PF09785; Q6NU94 CHOYP_BRAFLDRAFT_119955.1.1 m.16485 sp TRMB_XENLA 67.729 251 66 2 4 241 15 263 9.38E-125 358 TRMB_XENLA reviewed tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) mettl1 Xenopus laevis (African clawed frog) 273 tRNA modification [GO:0006400] GO:0000049; GO:0005634; GO:0006400; GO:0008176 PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03055}. 0 0 PF02390; Q6ZRF8 CHOYP_LOC100368020.15.29 m.31334 sp RN207_HUMAN 22.816 206 141 8 16 217 103 294 9.38E-10 62 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7ZYB4 CHOYP_LOC100378892.1.1 m.41502 sp PAIP1_XENLA 32.402 358 213 11 62 414 106 439 9.38E-44 162 PAIP1_XENLA reviewed Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Paip1 protein) (Poly(A)-binding protein-interacting protein 1) (XlPaip1) paip1 Xenopus laevis (African clawed frog) 463 0 GO:0003723; GO:0005737; GO:0008494 0 0 0 PF02854; Q99MQ1 CHOYP_LOC101172881.1.2 m.16580 sp BICC1_MOUSE 29.787 94 62 1 64 153 862 955 9.38E-06 52.4 BICC1_MOUSE reviewed Protein bicaudal C homolog 1 (Bic-C) Bicc1 Mus musculus (Mouse) 977 determination of left/right symmetry [GO:0007368]; heart development [GO:0007507]; negative regulation of canonical Wnt signaling pathway [GO:0090090] GO:0003723; GO:0005737; GO:0007368; GO:0007507; GO:0044822; GO:0090090 0 0 0 PF00013;PF00536; Q9Y2U5 CHOYP_M3K2.1.1 m.66663 sp M3K2_HUMAN 46.106 642 282 22 1 604 1 616 9.38E-157 466 M3K2_HUMAN reviewed Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) MAP3K2 MAPKKK2 MEKK2 Homo sapiens (Human) 619 "activation of JUN kinase activity [GO:0007257]; activation of MAPK activity [GO:0000187]; cellular response to mechanical stimulus [GO:0071260]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]" GO:0000187; GO:0004672; GO:0004674; GO:0004702; GO:0004709; GO:0005524; GO:0005654; GO:0005737; GO:0005829; GO:0006468; GO:0007257; GO:0019901; GO:0045893; GO:0046872; GO:0071260 0 0 0 PF00564;PF00069; A7RWD2 CHOYP_CIAO1.1.1 m.48324 sp CIAO1_NEMVE 70.898 323 94 0 10 332 1 323 9.39E-175 490 CIAO1_NEMVE reviewed Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog v1g226592 Nematostella vectensis (Starlet sea anemone) 327 iron-sulfur cluster assembly [GO:0016226] GO:0016226; GO:0097361 0 0 0 PF00400; O57429 CHOYP_UBP5.1.1 m.3809 sp UBP2_CHICK 26.608 342 193 15 159 455 21 349 9.39E-18 87.8 UBP2_CHICK reviewed Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) USP2 UBP41 Gallus gallus (Chicken) 357 protein deubiquitination [GO:0016579]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004843; GO:0006511; GO:0016579; GO:0046872; GO:0048471; GO:0048511 0 0 0 PF00443; P00450 CHOYP_BRAFLDRAFT_74383.1.1 m.14280 sp CERU_HUMAN 30.208 288 174 7 62 322 713 1000 9.39E-35 139 CERU_HUMAN reviewed Ceruloplasmin (EC 1.16.3.1) (Ferroxidase) CP Homo sapiens (Human) 1065 aging [GO:0007568]; cellular iron ion homeostasis [GO:0006879]; copper ion transport [GO:0006825]; liver development [GO:0001889]; lung development [GO:0030324]; response to copper ion [GO:0046688]; response to nutrient [GO:0007584] GO:0001889; GO:0004322; GO:0005507; GO:0005576; GO:0005615; GO:0005765; GO:0006825; GO:0006879; GO:0007568; GO:0007584; GO:0030324; GO:0046658; GO:0046688; GO:0051087; GO:0070062; GO:0072562 0 0 0 PF00394;PF07731;PF07732; P35440 CHOYP_BRAFLDRAFT_247279.1.1 m.2850 sp TSP2_CHICK 42.241 116 63 3 58 172 443 555 9.39E-19 89 TSP2_CHICK reviewed Thrombospondin-2 THBS2 TSP2 Gallus gallus (Chicken) 1178 cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525] GO:0005509; GO:0005604; GO:0007155; GO:0008201; GO:0016525; GO:0031091 0 0 0 PF12947;PF00090;PF02412;PF05735;PF00093; P55040 CHOYP_CPIPJ_CPIJ018731.1.1 m.2239 sp GEM_HUMAN 37.391 115 63 2 9 114 135 249 9.39E-17 78.2 GEM_HUMAN reviewed GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) GEM KIR Homo sapiens (Human) 296 cell surface receptor signaling pathway [GO:0007166]; chromosome organization [GO:0051276]; immune response [GO:0006955]; metaphase plate congression [GO:0051310]; mitotic nuclear division [GO:0007067]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264] GO:0000287; GO:0003924; GO:0005525; GO:0005634; GO:0006955; GO:0007067; GO:0007165; GO:0007166; GO:0007264; GO:0009898; GO:0019003; GO:0030496; GO:0051233; GO:0051276; GO:0051310; GO:0072686 0 0 0 PF00071; P86948 CHOYP_AAEL_AAEL007437.1.1 m.29443 sp MP_PINMA 44.444 108 53 1 1 101 1 108 9.39E-17 77 MP_PINMA reviewed Mantle protein (MP) 0 Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster) 260 0 GO:0005576 0 0 0 0 Q09654 CHOYP_LOC100373444.79.79 m.65047 sp TRI23_CAEEL 25.381 197 133 8 24 209 119 312 9.39E-07 53.1 TRI23_CAEEL reviewed E3 ubiquitin-protein ligase arc-1 (EC 6.3.2.-) (Putative GTP-binding protein trim-23 homolog) arc-1 arl-4 ZK1320.6 Caenorhabditis elegans 539 protein ubiquitination [GO:0016567]; small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00025;PF00643;PF13445; Q13442 CHOYP_BRAFLDRAFT_118658.1.2 m.49602 sp HAP28_HUMAN 64.557 79 27 1 424 502 72 149 9.39E-22 95.9 HAP28_HUMAN reviewed 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) PDAP1 HASPP28 Homo sapiens (Human) 181 cell proliferation [GO:0008283]; signal transduction [GO:0007165] GO:0007165; GO:0008283; GO:0044822 0 0 0 PF10252; Q5VST9 CHOYP_TTN.8.9 m.50598 sp OBSCN_HUMAN 26.544 1247 808 26 41 1253 2108 3280 9.39E-93 342 OBSCN_HUMAN reviewed Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) OBSCN KIAA1556 KIAA1639 Homo sapiens (Human) 7968 mitophagy in response to mitochondrial depolarization [GO:0098779]; multicellular organism development [GO:0007275]; positive regulation of apoptotic process [GO:0043065]; protein localization to M-band [GO:0036309]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; sarcomere organization [GO:0045214] GO:0004674; GO:0005085; GO:0005089; GO:0005524; GO:0005829; GO:0007275; GO:0008307; GO:0030016; GO:0030018; GO:0030506; GO:0031430; GO:0031432; GO:0035023; GO:0036309; GO:0043065; GO:0045214; GO:0046872; GO:0051056; GO:0098779 0 0 0 PF00041;PF07679;PF00612;PF00069;PF00621; Q63060 CHOYP_LOC101157895.1.2 m.1104 sp GLPK_RAT 44.227 511 279 2 10 520 11 515 9.39E-153 449 GLPK_RAT reviewed Glycerol kinase (GK) (Glycerokinase) (EC 2.7.1.30) (ATP-stimulated glucocorticoid-receptor translocation promoter) (ASTP) (ATP:glycerol 3-phosphotransferase) Gk Gyk Rattus norvegicus (Rat) 524 glycerol-3-phosphate biosynthetic process [GO:0046167]; glycerol catabolic process [GO:0019563]; glycerol metabolic process [GO:0006071]; response to cold [GO:0009409]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to organic substance [GO:0010033]; triglyceride metabolic process [GO:0006641] GO:0004370; GO:0005524; GO:0005634; GO:0005739; GO:0005741; GO:0006071; GO:0006641; GO:0009409; GO:0010033; GO:0019563; GO:0042393; GO:0042493; GO:0045471; GO:0046167 PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. 0 0 PF02782;PF00370; Q6NYV5 CHOYP_LOC583865.2.2 m.15485 sp SP30L_DANRE 63.529 170 56 1 75 238 1 170 9.39E-73 222 SP30L_DANRE reviewed Histone deacetylase complex subunit SAP30L (Sin3 corepressor complex subunit SAP30L) (Sin3-associated protein p30-like) sap30l Danio rerio (Zebrafish) (Brachydanio rerio) 178 "heart looping [GO:0001947]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001947; GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF13867;PF13866; Q99M80 CHOYP_PTPRK.16.20 m.45510 sp PTPRT_MOUSE 29.973 744 465 15 391 1099 731 1453 9.39E-86 308 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9CRA8 CHOYP_BRAFLDRAFT_124523.1.1 m.18960 sp EXOS5_MOUSE 46.698 212 113 0 31 242 23 234 9.39E-67 209 EXOS5_MOUSE reviewed Exosome complex component RRP46 (Exosome component 5) (Ribosomal RNA-processing protein 46) Exosc5 D7Wsu180e Rrp46 Mus musculus (Mouse) 235 "defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; RNA catabolic process [GO:0006401]; rRNA 3'-end processing [GO:0031125]; rRNA catabolic process [GO:0016075]; U4 snRNA 3'-end processing [GO:0034475]" GO:0000176; GO:0000177; GO:0000178; GO:0003723; GO:0005634; GO:0005730; GO:0006401; GO:0016075; GO:0031125; GO:0034427; GO:0034475; GO:0035327; GO:0043928; GO:0045006; GO:0051607; GO:0071028; GO:0071051 0 0 0 PF01138;PF03725; Q9JIK5 CHOYP_LOC581409.1.1 m.40958 sp DDX21_MOUSE 38.281 128 77 1 46 171 624 751 9.39E-18 83.2 DDX21_MOUSE reviewed Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu) Ddx21 Mus musculus (Mouse) 851 osteoblast differentiation [GO:0001649]; response to exogenous dsRNA [GO:0043330]; response to virus [GO:0009615]; RNA secondary structure unwinding [GO:0010501]; rRNA processing [GO:0006364]; transcription from RNA polymerase II promoter [GO:0006366] GO:0001649; GO:0003723; GO:0003724; GO:0003725; GO:0004004; GO:0005524; GO:0005634; GO:0005654; GO:0005730; GO:0006364; GO:0006366; GO:0009615; GO:0010501; GO:0016020; GO:0019843; GO:0030515; GO:0043330; GO:0044822; GO:0097322 0 0 0 PF00270;PF08152;PF00271; Q9VU02 CHOYP_LOC552559.1.2 m.39702 sp SMD1_DROME 84.615 91 14 0 1 91 1 91 9.39E-54 166 SMD1_DROME reviewed Probable small nuclear ribonucleoprotein Sm D1 (Sm-D1) (snRNP core protein D1) SmD1 snRNP69D CG10753 Drosophila melanogaster (Fruit fly) 124 "mRNA splicing, via spliceosome [GO:0000398]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]" GO:0000243; GO:0000245; GO:0000387; GO:0000398; GO:0003723; GO:0005634; GO:0005681; GO:0005682; GO:0005685; GO:0005686; GO:0005687; GO:0005689; GO:0005829; GO:0030532; GO:0034715; GO:0034719; GO:0044822; GO:0071010; GO:0071011; GO:0071013; GO:0097526 0 0 0 PF01423; O01359 CHOYP_RLA1.3.12 m.12071 sp RLA1_OSCTI 60.714 112 43 1 1 111 1 112 9.40E-33 113 RLA1_OSCTI reviewed 60S acidic ribosomal protein P1 (Ribosomal protein RPL-21) rpl-21 Oscheius tipulae 112 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O01359 CHOYP_RPS11.1.5 m.11993 sp RLA1_OSCTI 60.714 112 43 1 1 111 1 112 9.40E-33 113 RLA1_OSCTI reviewed 60S acidic ribosomal protein P1 (Ribosomal protein RPL-21) rpl-21 Oscheius tipulae 112 translational elongation [GO:0006414] GO:0003735; GO:0005840; GO:0006414 0 0 0 0 O88572 CHOYP_LOC578656.14.15 m.63526 sp LRP6_MOUSE 26.304 863 583 25 137 975 100 933 9.40E-82 299 LRP6_MOUSE reviewed Low-density lipoprotein receptor-related protein 6 (LRP-6) Lrp6 Mus musculus (Mouse) 1613 "anterior/posterior pattern specification [GO:0009952]; axis elongation [GO:0003401]; axis elongation involved in somitogenesis [GO:0090245]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [GO:0061310]; canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [GO:0061324]; cell migration involved in gastrulation [GO:0042074]; cellular response to cholesterol [GO:0071397]; cerebellum morphogenesis [GO:0021587]; cerebral cortex cell migration [GO:0021795]; cerebral cortex development [GO:0021987]; chemical synaptic transmission [GO:0007268]; convergent extension [GO:0060026]; dopaminergic neuron differentiation [GO:0071542]; dorsal/ventral axis specification [GO:0009950]; embryonic camera-type eye morphogenesis [GO:0048596]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic limb morphogenesis [GO:0030326]; embryonic pattern specification [GO:0009880]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; external genitalia morphogenesis [GO:0035261]; face morphogenesis [GO:0060325]; forebrain development [GO:0030900]; forebrain generation of neurons [GO:0021872]; forebrain radial glial cell differentiation [GO:0021861]; formation of radial glial scaffolds [GO:0021943]; gastrulation with mouth forming second [GO:0001702]; generation of neurons [GO:0048699]; heart looping [GO:0001947]; limb morphogenesis [GO:0035108]; mammary gland duct morphogenesis [GO:0060603]; mammary placode formation [GO:0060596]; midbrain development [GO:0030901]; midbrain-hindbrain boundary development [GO:0030917]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:2000151]; negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:2000162]; negative regulation of planar cell polarity pathway involved in neural tube closure [GO:2000168]; negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [GO:2000164]; negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [GO:2000166]; negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [GO:2000149]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; negative regulation of smooth muscle cell apoptotic process [GO:0034392]; negative regulation of Wnt signaling pathway [GO:0030178]; neural crest cell differentiation [GO:0014033]; neural crest formation [GO:0014029]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; odontogenesis of dentin-containing tooth [GO:0042475]; palate development [GO:0060021]; pericardium morphogenesis [GO:0003344]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone resorption [GO:0045780]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell cycle [GO:0045787]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of ossification [GO:0045778]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; post-anal tail morphogenesis [GO:0036342]; primitive streak formation [GO:0090009]; protein localization to plasma membrane [GO:0072659]; receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [GO:0090118]; regulation of cell development [GO:0060284]; regulation of cell proliferation [GO:0042127]; response to folic acid [GO:0051593]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal system morphogenesis [GO:0048705]; somitogenesis [GO:0001756]; thalamus development [GO:0021794]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in dorsal/ventral axis specification [GO:0044332]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in somitogenesis [GO:0090244]" GO:0001702; GO:0001756; GO:0001843; GO:0001933; GO:0001947; GO:0002053; GO:0003344; GO:0003401; GO:0005041; GO:0005102; GO:0005109; GO:0005769; GO:0005783; GO:0005886; GO:0005901; GO:0006469; GO:0007268; GO:0009880; GO:0009950; GO:0009952; GO:0009986; GO:0014029; GO:0014033; GO:0016020; GO:0016021; GO:0016055; GO:0017147; GO:0019210; GO:0019534; GO:0021587; GO:0021794; GO:0021795; GO:0021861; GO:0021872; GO:0021874; GO:0021915; GO:0021943; GO:0021987; GO:0030178; GO:0030326; GO:0030900; GO:0030901; GO:0030917; GO:0031410; GO:0034392; GO:0035108; GO:0035115; GO:0035116; GO:0035261; GO:0036342; GO:0042074; GO:0042127; GO:0042475; GO:0042733; GO:0042802; GO:0042803; GO:0042813; GO:0043025; GO:0043065; GO:0043235; GO:0044332; GO:0045202; GO:0045599; GO:0045778; GO:0045780; GO:0045787; GO:0045893; GO:0045944; GO:0046849; GO:0048596; GO:0048699; GO:0048705; GO:0050680; GO:0051091; GO:0051593; GO:0060021; GO:0060026; GO:0060042; GO:0060059; GO:0060070; GO:0060284; GO:0060325; GO:0060444; GO:0060535; GO:0060596; GO:0060603; GO:0061310; GO:0061324; GO:0071397; GO:0071542; GO:0071901; GO:0071936; GO:0072659; GO:0090009; GO:0090118; GO:0090244; GO:0090245; GO:0090263; GO:1990851; GO:1990909; GO:2000051; GO:2000055; GO:2000149; GO:2000151; GO:2000162; GO:2000164; GO:2000166; GO:2000168 0 0 0 PF00057;PF00058; P0C6B8 CHOYP_LOC100367084.1.22 m.16955 sp SVEP1_RAT 24.526 685 415 22 110 707 436 1105 9.40E-29 130 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P12394 CHOYP_LOC100367956.1.2 m.5378 sp CP17A_CHICK 28.251 223 156 4 41 260 38 259 9.40E-26 110 CP17A_CHICK reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Gallus gallus (Chicken) 508 hormone biosynthetic process [GO:0042446]; sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694]; steroid metabolic process [GO:0008202] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0008202; GO:0016020; GO:0020037; GO:0042446; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; P57768 CHOYP_SNX16.1.1 m.56833 sp SNX16_HUMAN 50.239 209 98 3 80 286 69 273 9.40E-66 216 SNX16_HUMAN reviewed Sorting nexin-16 SNX16 Homo sapiens (Human) 344 early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; protein targeting to lysosome [GO:0006622] GO:0005764; GO:0005769; GO:0005770; GO:0005829; GO:0006622; GO:0008333; GO:0031313; GO:0031901; GO:0031902; GO:0035091; GO:0042802; GO:0045022 0 0 0 PF00787; Q4ZJM9 CHOYP_CBLN7.3.3 m.66960 sp C1QL4_MOUSE 32.061 131 78 5 45 169 110 235 9.40E-10 58.9 C1QL4_MOUSE reviewed Complement C1q-like protein 4 (C1q and tumor necrosis factor-related protein 11) (C1q/TNF-related protein 11) (C1qTNF11) (CTRP11) C1ql4 C1qtnf11 Ctrp11 Mus musculus (Mouse) 238 negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast proliferation [GO:0048147] GO:0005581; GO:0005615; GO:0042802; GO:0045599; GO:0048147; GO:0070373 0 0 0 PF00386; Q8IWZ3 CHOYP_LOC579631.1.4 m.24448 sp ANKH1_HUMAN 42.308 130 72 3 4 130 369 498 9.40E-22 93.2 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q9GZ71 CHOYP_LOC100179300.1.2 m.22735 sp TPM_HALDV 73.134 134 36 0 1 134 1 134 9.40E-58 183 TPM_HALDV reviewed Tropomyosin 0 Haliotis diversicolor (Abalone) (Sulculus diversicolor) 284 0 0 0 0 0 PF00261; Q9JIS1 CHOYP_RIMS2.3.3 m.52560 sp RIMS2_RAT 36.962 836 401 34 14 821 26 763 9.40E-103 351 RIMS2_RAT reviewed Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) Rims2 Rim2 Rattus norvegicus (Rat) 1555 calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cAMP-mediated signaling [GO:0019933]; cell differentiation [GO:0030154]; exocytosis [GO:0006887]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; spontaneous neurotransmitter secretion [GO:0061669] GO:0005622; GO:0006886; GO:0006887; GO:0010628; GO:0017156; GO:0017157; GO:0019904; GO:0019933; GO:0030054; GO:0030073; GO:0030154; GO:0042391; GO:0042734; GO:0043234; GO:0044325; GO:0045202; GO:0046872; GO:0046982; GO:0048786; GO:0048791; GO:0061669; GO:0097151; GO:2000463 0 0 0 PF00168;PF02318; Q9R0M3 CHOYP_LOC593709.2.2 m.31966 sp SRPX_MOUSE 27.368 190 131 6 400 586 120 305 9.40E-13 74.3 SRPX_MOUSE reviewed Sushi-repeat-containing protein SRPX (DRS protein) Srpx Mus musculus (Mouse) 464 autophagy [GO:0006914]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976] GO:0001845; GO:0005776; GO:0005783; GO:0006914; GO:0034976; GO:0060244; GO:2001241 0 0 0 PF13778;PF02494;PF00084; O14522 CHOYP_PTPRT.42.45 m.61851 sp PTPRT_HUMAN 31.732 583 377 9 17 582 860 1438 9.41E-82 283 PTPRT_HUMAN reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) PTPRT KIAA0283 Homo sapiens (Human) 1441 cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007155; GO:0007156; GO:0007165; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0045294; GO:0045295; GO:0045296; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; P07207 CHOYP_LOC100374832.5.5 m.58494 sp NOTCH_DROME 46.377 69 30 3 675 738 674 740 9.41E-10 66.2 NOTCH_DROME reviewed Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein] N CG3936 Drosophila melanogaster (Fruit fly) 2703 "actin filament organization [GO:0007015]; anterior/posterior pattern specification [GO:0009952]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; border follicle cell migration [GO:0007298]; cell adhesion [GO:0007155]; cell fate specification [GO:0001708]; chaeta development [GO:0022416]; chaeta morphogenesis [GO:0008407]; compound eye cone cell fate commitment [GO:0042676]; compound eye development [GO:0048749]; compound eye morphogenesis [GO:0001745]; compound eye retinal cell programmed cell death [GO:0046667]; crystal cell differentiation [GO:0042688]; determination of adult lifespan [GO:0008340]; dorsal/ventral lineage restriction, imaginal disc [GO:0007451]; dorsal/ventral pattern formation, imaginal disc [GO:0007450]; dorsal appendage formation [GO:0046843]; dorsal closure [GO:0007391]; ectoderm development [GO:0007398]; embryonic crystal cell differentiation [GO:0035165]; embryonic hemopoiesis [GO:0035162]; epithelial cell proliferation involved in Malpighian tubule morphogenesis [GO:0061331]; epithelial cell type specification, open tracheal system [GO:0035153]; epithelium development [GO:0060429]; establishment of ommatidial planar polarity [GO:0042067]; eye-antennal disc development [GO:0035214]; female germ-line stem cell population maintenance [GO:0036099]; foregut morphogenesis [GO:0007440]; formation of a compartment boundary [GO:0060288]; germarium-derived egg chamber formation [GO:0007293]; germarium-derived female germ-line cyst encapsulation [GO:0030708]; germ-line stem-cell niche homeostasis [GO:0060250]; germ-line stem cell population maintenance [GO:0030718]; glial cell differentiation [GO:0010001]; glial cell fate determination [GO:0007403]; glial cell migration [GO:0008347]; hemocyte proliferation [GO:0035172]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; I-kappaB phosphorylation [GO:0007252]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; imaginal disc-derived leg segmentation [GO:0036011]; imaginal disc-derived male genitalia morphogenesis [GO:0048803]; imaginal disc-derived wing margin morphogenesis [GO:0008587]; imaginal disc-derived wing morphogenesis [GO:0007476]; imaginal disc-derived wing vein specification [GO:0007474]; imaginal disc growth [GO:0007446]; imaginal disc pattern formation [GO:0007447]; intestinal stem cell homeostasis [GO:0036335]; lamellocyte differentiation [GO:0035171]; larval lymph gland hemopoiesis [GO:0035167]; lateral inhibition [GO:0046331]; leg disc morphogenesis [GO:0007478]; long-term memory [GO:0007616]; lymph gland crystal cell differentiation [GO:0035170]; lymph gland development [GO:0048542]; Malpighian tubule tip cell differentiation [GO:0061382]; mesoderm development [GO:0007498]; morphogenesis of follicular epithelium [GO:0016333]; motor neuron axon guidance [GO:0008045]; muscle cell fate determination [GO:0007521]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of compound eye photoreceptor development [GO:0045316]; negative regulation of fusion cell fate specification [GO:0035157]; negative regulation of gene expression [GO:0010629]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neuroblast fate determination [GO:0007400]; neurological system process [GO:0050877]; neuron development [GO:0048666]; Notch signaling pathway [GO:0007219]; oocyte anterior/posterior axis specification [GO:0007314]; oocyte localization involved in germarium-derived egg chamber formation [GO:0030720]; oogenesis [GO:0048477]; open tracheal system development [GO:0007424]; ovarian follicle cell development [GO:0030707]; ovarian follicle cell migration [GO:0007297]; ovarian follicle cell stalk formation [GO:0030713]; peripheral nervous system development [GO:0007422]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; R1/R6 cell differentiation [GO:0048052]; R3/R4 cell fate commitment [GO:0007464]; R7 cell differentiation [GO:0045466]; R8 cell development [GO:0045463]; R8 cell differentiation [GO:0045465]; R8 cell fate commitment [GO:0007460]; regulation of cardioblast cell fate specification [GO:0042686]; regulation of cell differentiation [GO:0045595]; regulation of crystal cell differentiation [GO:0042689]; regulation of filopodium assembly [GO:0051489]; regulation of glucose metabolic process [GO:0010906]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]; regulation of neurogenesis [GO:0050767]; regulation of R8 cell spacing in compound eye [GO:0045468]; response to symbiont [GO:0009608]; retinal cell programmed cell death [GO:0046666]; second mitotic wave involved in compound eye morphogenesis [GO:0016330]; sensory organ development [GO:0007423]; skeletal muscle tissue development [GO:0007519]; stem cell differentiation [GO:0048863]; transcription, DNA-templated [GO:0006351]; ventral cord development [GO:0007419]; wing disc dorsal/ventral pattern formation [GO:0048190]; wing disc pattern formation [GO:0035222]; wing disc proximal/distal pattern formation [GO:0007473]" GO:0000122; GO:0001708; GO:0001745; GO:0003682; GO:0004872; GO:0004888; GO:0005509; GO:0005622; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005770; GO:0005788; GO:0005796; GO:0005829; GO:0005886; GO:0005912; GO:0006351; GO:0007015; GO:0007155; GO:0007157; GO:0007219; GO:0007252; GO:0007293; GO:0007297; GO:0007298; GO:0007314; GO:0007346; GO:0007391; GO:0007398; GO:0007400; GO:0007403; GO:0007411; GO:0007419; GO:0007422; GO:0007423; GO:0007424; GO:0007440; GO:0007446; GO:0007447; GO:0007450; GO:0007451; GO:0007460; GO:0007464; GO:0007473; GO:0007474; GO:0007476; GO:0007478; GO:0007498; GO:0007519; GO:0007521; GO:0007616; GO:0008045; GO:0008284; GO:0008340; GO:0008347; GO:0008356; GO:0008407; GO:0008587; GO:0009608; GO:0009952; GO:0009986; GO:0010001; GO:0010629; GO:0010906; GO:0016021; GO:0016330; GO:0016333; GO:0016348; GO:0022416; GO:0030139; GO:0030707; GO:0030708; GO:0030713; GO:0030718; GO:0030720; GO:0035003; GO:0035153; GO:0035155; GO:0035157; GO:0035162; GO:0035165; GO:0035167; GO:0035170; GO:0035171; GO:0035172; GO:0035214; GO:0035222; GO:0036011; GO:0036099; GO:0036335; GO:0040008; GO:0042067; GO:0042676; GO:0042686; GO:0042688; GO:0042689; GO:0043234; GO:0045316; GO:0045463; GO:0045465; GO:0045466; GO:0045468; GO:0045595; GO:0045747; GO:0045944; GO:0046329; GO:0046331; GO:0046666; GO:0046667; GO:0046843; GO:0048052; GO:0048190; GO:0048477; GO:0048542; GO:0048666; GO:0048749; GO:0048803; GO:0048863; GO:0050767; GO:0050768; GO:0050877; GO:0051489; GO:0060250; GO:0060288; GO:0060429; GO:0061331; GO:0061382; GO:1900087; GO:2000048 0 0 0 PF12796;PF11936;PF00008;PF07645;PF12661;PF06816;PF07684;PF00066; P10079 CHOYP_NEMVEDRAFT_V1G52068.3.3 m.41797 sp FBP1_STRPU 55 180 81 0 2 181 185 364 9.41E-57 201 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P16157 CHOYP_TVAG_168010.5.45 m.20064 sp ANK1_HUMAN 33.445 299 193 1 340 638 301 593 9.41E-46 179 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P18426 CHOYP_LOC100376457.2.2 m.51737 sp SCR11_NOTSL 38.537 205 121 4 1 203 1 202 9.41E-44 148 SCR11_NOTSL reviewed S-crystallin SL11 (Major lens polypeptide) 0 Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei) 205 0 GO:0005212 0 0 0 PF14497;PF02798; P24350 CHOYP_CPIPJ_CPIJ014571.1.1 m.59654 sp IPOU_DROME 57.831 332 79 15 37 327 73 384 9.41E-100 302 IPOU_DROME reviewed Inhibitory POU protein (I-POU) (Abnormal chemosensory jump 6 protein) acj6 Ipou CG9151 Drosophila melanogaster (Fruit fly) 396 "axon guidance [GO:0007411]; chemosensory jump behavior [GO:0007636]; dendrite guidance [GO:0070983]; dendrite morphogenesis [GO:0048813]; detection of chemical stimulus involved in sensory perception of smell [GO:0050911]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; synaptic target recognition [GO:0008039]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003714; GO:0005634; GO:0006351; GO:0007411; GO:0007636; GO:0008039; GO:0043565; GO:0045944; GO:0048813; GO:0050911; GO:0070983 0 0 0 PF00046;PF00157; P34121 CHOYP_LOC100533357.1.2 m.56848 sp COAA_DICDI 33.083 133 87 2 189 320 6 137 9.41E-17 79 COAA_DICDI reviewed Coactosin (Cyclic AMP-regulated protein p16) (Cytoskeletal protein p17) coaA p17 DDB_G0293898 Dictyostelium discoideum (Slime mold) 146 regulation of actin filament polymerization [GO:0030833]; response to bacterium [GO:0009617] GO:0009617; GO:0015629; GO:0030833; GO:0045335; GO:0051015 0 0 0 PF00241; P48441 CHOYP_LOC101070380.1.1 m.16515 sp IDUA_MOUSE 52.941 272 127 1 163 433 20 291 9.41E-99 311 IDUA_MOUSE reviewed Alpha-L-iduronidase (EC 3.2.1.76) Idua Mus musculus (Mouse) 634 carbohydrate metabolic process [GO:0005975]; cell morphogenesis [GO:0000902]; chemical homeostasis [GO:0048878]; dermatan sulfate catabolic process [GO:0030209]; limb morphogenesis [GO:0035108]; lysosome organization [GO:0007040]; skeletal system morphogenesis [GO:0048705] GO:0000902; GO:0003940; GO:0005764; GO:0005975; GO:0007040; GO:0030209; GO:0035108; GO:0048705; GO:0048878; GO:0070062 0 0 0 PF01229; P81439 CHOYP_NID2.1.2 m.5776 sp EQST_ACTEQ 32.298 161 93 9 95 253 53 199 9.41E-11 63.2 EQST_ACTEQ reviewed Equistatin 0 Actinia equina (Beadlet anemone) 199 0 GO:0004869; GO:0005576 0 0 0 PF00086; Q08288 CHOYP_MGC78792.1.1 m.45233 sp LYAR_MOUSE 35.369 393 180 9 27 355 1 383 9.41E-64 211 LYAR_MOUSE reviewed Cell growth-regulating nucleolar protein (Protein expressed in male leptotene and zygotene spermatocytes 264) (MLZ-264) Lyar Mus musculus (Mouse) 388 0 GO:0005634; GO:0005730; GO:0044822; GO:0046872 0 0 0 PF08790; Q13541 CHOYP_4EBP1.1.1 m.12045 sp 4EBP1_HUMAN 56.881 109 42 4 42 147 12 118 9.41E-34 117 4EBP1_HUMAN reviewed Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) EIF4EBP1 Homo sapiens (Human) 118 cellular response to hypoxia [GO:0071456]; G1/S transition of mitotic cell cycle [GO:0000082]; insulin receptor signaling pathway [GO:0008286]; IRES-dependent translational initiation [GO:0002192]; lung development [GO:0030324]; negative regulation of protein complex assembly [GO:0031333]; negative regulation of translational initiation [GO:0045947]; positive regulation of mitotic cell cycle [GO:0045931]; response to ethanol [GO:0045471]; response to ischemia [GO:0002931]; TOR signaling [GO:0031929] GO:0000082; GO:0002192; GO:0002931; GO:0005654; GO:0005737; GO:0005829; GO:0008190; GO:0008286; GO:0030324; GO:0030371; GO:0031333; GO:0031929; GO:0043234; GO:0045471; GO:0045931; GO:0045947; GO:0071456 0 0 0 PF05456; Q2KIR1 CHOYP_LOC100377235.1.2 m.30935 sp SNRPA_BOVIN 61.511 278 60 4 2 232 5 282 9.41E-110 319 SNRPA_BOVIN reviewed U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) SNRPA Bos taurus (Bovine) 282 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005654; GO:0005681; GO:0005685; GO:0005730; GO:0005737; GO:0030619; GO:0035614; GO:0044822 0 0 0 PF00076; Q2KIR1 CHOYP_TTF2.1.1 m.10375 sp SNRPA_BOVIN 61.511 278 60 4 2 232 5 282 9.41E-110 319 SNRPA_BOVIN reviewed U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A) SNRPA Bos taurus (Bovine) 282 "mRNA splicing, via spliceosome [GO:0000398]" GO:0000166; GO:0000398; GO:0003723; GO:0005654; GO:0005681; GO:0005685; GO:0005730; GO:0005737; GO:0030619; GO:0035614; GO:0044822 0 0 0 PF00076; Q54271 CHOYP_NEMVEDRAFT_V1G168076.2.2 m.56942 sp PPD_STRHY 29.487 390 248 8 100 475 1 377 9.41E-48 172 PPD_STRHY reviewed Phosphonopyruvate decarboxylase (EC 4.1.1.82) bcpC Streptomyces hygroscopicus 401 antibiotic biosynthetic process [GO:0017000]; organic phosphonate biosynthetic process [GO:0032923] GO:0017000; GO:0030976; GO:0032923; GO:0033980 PATHWAY: Secondary metabolite biosynthesis; bialaphos biosynthesis. 0 0 PF02775;PF02776; Q90660 CHOYP_contig_020223 m.23457 sp BIR_CHICK 36.486 74 43 2 4 77 21 90 9.41E-07 52.8 BIR_CHICK reviewed Inhibitor of apoptosis protein (IAP) (Inhibitor of T-cell apoptosis protein) ITA IAP1 Gallus gallus (Chicken) 611 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of necroptotic process [GO:0060546]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005737; GO:0008270; GO:0034121; GO:0043027; GO:0043066; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; Q99572 CHOYP_BRAFLDRAFT_67258.12.18 m.47676 sp P2RX7_HUMAN 30.4 125 67 4 67 178 476 593 9.41E-07 51.6 P2RX7_HUMAN reviewed P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) P2RX7 Homo sapiens (Human) 595 activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to dsRNA [GO:0071359]; cellular response to extracellular stimulus [GO:0031668]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; cytolysis [GO:0019835]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; membrane budding [GO:0006900]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; multicellular organismal protein catabolic process [GO:0044254]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to drug [GO:0042493]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098] GO:0000187; GO:0000902; GO:0001530; GO:0001614; GO:0001845; GO:0001916; GO:0002028; GO:0004931; GO:0005102; GO:0005524; GO:0005639; GO:0005737; GO:0005886; GO:0005887; GO:0005911; GO:0006468; GO:0006509; GO:0006649; GO:0006900; GO:0006954; GO:0007005; GO:0007166; GO:0007596; GO:0009612; GO:0009897; GO:0010043; GO:0010524; GO:0010628; GO:0014049; GO:0014054; GO:0016020; GO:0016079; GO:0016485; GO:0017121; GO:0019233; GO:0019835; GO:0030501; GO:0031594; GO:0031668; GO:0032059; GO:0032060; GO:0032308; GO:0032496; GO:0032755; GO:0032963; GO:0033198; GO:0034405; GO:0034767; GO:0035590; GO:0042098; GO:0042493; GO:0042803; GO:0043025; GO:0043029; GO:0043132; GO:0043409; GO:0044254; GO:0045332; GO:0045779; GO:0045794; GO:0045821; GO:0045919; GO:0046513; GO:0046931; GO:0048705; GO:0048873; GO:0050717; GO:0050718; GO:0050830; GO:0051209; GO:0051259; GO:0051495; GO:0051592; GO:0051602; GO:0051709; GO:0051899; GO:0051901; GO:0070230; GO:0071359; GO:0072593; GO:0097190; GO:0097191; GO:0098793; GO:1904172 0 0 0 PF00864; B8NI03 CHOYP_MNOD_3660.1.1 m.27828 sp HYPC_ASPFN 30.4 125 84 3 12 133 54 178 9.42E-10 58.2 HYPC_ASPFN reviewed Noranthrone monooxygenase (EC 1.13.12.20) hypC AFLA_139400 Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167) 210 aflatoxin biosynthetic process [GO:0045122] GO:0004497; GO:0016021; GO:0045122 PATHWAY: Mycotoxin biosynthesis; aflatoxin biosynthesis. {ECO:0000269|PubMed:20348292}. 0 0 PF08592; O01404 CHOYP_LOC100876663.1.1 m.4368 sp PHM_DROME 50.489 307 137 7 31 328 49 349 9.42E-99 301 PHM_DROME reviewed Peptidylglycine alpha-hydroxylating monooxygenase (dPHM) (EC 1.14.17.3) Phm CG3832 Drosophila melanogaster (Fruit fly) 365 memory [GO:0007613]; multicellular organism reproduction [GO:0032504]; peptide metabolic process [GO:0006518]; regulation of imaginal disc-derived wing size [GO:0044719]; response to fungus [GO:0009620] GO:0004504; GO:0005507; GO:0005615; GO:0006518; GO:0007613; GO:0009620; GO:0016020; GO:0032504; GO:0044719 0 0 0 PF03712;PF01082; P04323 CHOYP_contig_020557 m.23729 sp POL3_DROME 40.812 468 264 6 225 685 163 624 9.42E-98 328 POL3_DROME reviewed Retrovirus-related Pol polyprotein from transposon 17.6 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1058 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P22987 CHOYP_MYCGRDRAFT_33593.1.1 m.7429 sp KIN1_SCHPO 41.667 144 74 3 1 144 269 402 9.42E-25 115 KIN1_SCHPO reviewed Protein kinase kin1 (EC 2.7.11.1) kin1 SPBC4F6.06 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 891 "cell growth mode switching, monopolar to bipolar [GO:0051523]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; establishment or maintenance of cell polarity regulating cell shape [GO:0071963]; intracellular signal transduction [GO:0035556]; mitotic cytokinesis, site selection [GO:1902408]; plasma membrane organization [GO:0007009]; protein phosphorylation [GO:0006468]" GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0007009; GO:0015630; GO:0030950; GO:0032153; GO:0032178; GO:0035556; GO:0035839; GO:0035841; GO:0035842; GO:0051286; GO:0051523; GO:0071963; GO:1902408; GO:1990873 0 0 0 PF02149;PF00069; P36993 CHOYP_Y0417.1.2 m.9130 sp PPM1B_MOUSE 49.802 253 124 3 489 739 130 381 9.42E-75 250 PPM1B_MOUSE reviewed Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta) Ppm1b Pp2c2 Pppm1b Mus musculus (Mouse) 390 negative regulation of defense response to virus [GO:0050687]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; N-terminal protein myristoylation [GO:0006499]; peptidyl-threonine dephosphorylation [GO:0035970]; protein dephosphorylation [GO:0006470] GO:0000287; GO:0004722; GO:0005829; GO:0006470; GO:0006499; GO:0016020; GO:0030145; GO:0032688; GO:0035970; GO:0042347; GO:0043124; GO:0050687 0 0 0 PF00481;PF07830; Q61361 CHOYP_contig_027795 m.31500 sp PGCB_MOUSE 32.576 132 78 3 39 170 665 785 9.42E-17 82 PGCB_MOUSE reviewed Brevican core protein Bcan Mus musculus (Mouse) 883 cell adhesion [GO:0007155]; hippocampus development [GO:0021766]; regulation of neuronal synaptic plasticity [GO:0048168]; skeletal system development [GO:0001501] GO:0001501; GO:0005201; GO:0005509; GO:0005540; GO:0005578; GO:0005615; GO:0007155; GO:0021766; GO:0030246; GO:0030425; GO:0031225; GO:0045202; GO:0048168 0 0 0 PF00008;PF00059;PF00084;PF07686;PF00193; Q8N695 CHOYP_SLC5A8.1.1 m.9590 sp SC5A8_HUMAN 38.511 618 361 10 6 621 10 610 9.42E-140 423 SC5A8_HUMAN reviewed Sodium-coupled monocarboxylate transporter 1 (Apical iodide transporter) (Electrogenic sodium monocarboxylate cotransporter) (Sodium iodide-related cotransporter) (Solute carrier family 5 member 8) SLC5A8 AIT SMCT SMCT1 Homo sapiens (Human) 610 apoptotic process [GO:0006915]; ion transport [GO:0006811]; sodium ion transport [GO:0006814] GO:0005886; GO:0005887; GO:0006811; GO:0006814; GO:0006915; GO:0008028; GO:0015293; GO:0016324; GO:0022803; GO:0070062 0 0 0 PF00474; Q8N865 CHOYP_LOC579012.1.1 m.10830 sp CG031_HUMAN 38.489 278 150 8 9 278 75 339 9.42E-42 165 CG031_HUMAN reviewed Uncharacterized protein C7orf31 C7orf31 Homo sapiens (Human) 590 0 GO:0005737; GO:0005813 0 0 0 PF15093; Q8WND5 CHOYP_LOC755638.1.1 m.64747 sp ELP1_RABIT 44.654 159 88 0 1 159 1035 1193 9.42E-35 131 ELP1_RABIT reviewed Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) IKBKAP ELP1 IKAP Oryctolagus cuniculus (Rabbit) 1333 "positive regulation of cell migration [GO:0030335]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; tRNA wobble uridine modification [GO:0002098]" GO:0002098; GO:0005737; GO:0006351; GO:0006357; GO:0008023; GO:0008607; GO:0030335; GO:0033588 0 0 0 PF04762; A5D7H5 CHOYP_BTZ.1.1 m.45914 sp CASC3_BOVIN 40.102 197 99 3 39 218 68 262 9.43E-29 127 CASC3_BOVIN reviewed Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein homolog) (MLN 51 homolog) (Protein barentsz) (Btz) CASC3 MLN51 Bos taurus (Bovine) 703 "intracellular mRNA localization [GO:0008298]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translation [GO:0006417]; RNA metabolic process [GO:0016070]; RNA splicing [GO:0008380]" GO:0000184; GO:0006397; GO:0006417; GO:0008298; GO:0008380; GO:0016070; GO:0016607; GO:0030529; GO:0035145; GO:0044822; GO:0048471; GO:0051028 0 0 0 PF09405; P26323 CHOYP_ERG.1.1 m.24108 sp FLI1_MOUSE 52.453 265 100 4 4 247 122 381 9.43E-89 273 FLI1_MOUSE reviewed Friend leukemia integration 1 transcription factor (Retroviral integration site protein Fli-1) Fli1 Fli-1 Mus musculus (Mouse) 452 "blood circulation [GO:0008015]; cellular process [GO:0009987]; megakaryocyte development [GO:0035855]; organ morphogenesis [GO:0009887]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000978; GO:0000980; GO:0001077; GO:0003682; GO:0005634; GO:0006355; GO:0008015; GO:0009887; GO:0009987; GO:0035855; GO:0043565; GO:0045944 0 0 0 PF00178;PF02198; Q0VGY8 CHOYP_TVAG_020440.13.21 m.32821 sp TANC1_MOUSE 41.844 141 81 1 7 147 1093 1232 9.43E-28 110 TANC1_MOUSE reviewed "Protein TANC1 (Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1)" Tanc1 Mus musculus (Mouse) 1856 dendritic spine maintenance [GO:0097062]; myoblast fusion [GO:0007520]; visual learning [GO:0008542] GO:0007520; GO:0008542; GO:0014069; GO:0030054; GO:0030425; GO:0043025; GO:0043679; GO:0045211; GO:0097062 0 0 0 PF00023;PF12796; Q12955 CHOYP_TVAG_212010.1.1 m.21586 sp ANK3_HUMAN 36.17 188 91 1 35 193 108 295 9.43E-31 121 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q5G267 CHOYP_BRAFLDRAFT_85664.9.10 m.45115 sp NETR_MACMU 45.982 224 117 3 863 1085 279 499 9.43E-55 209 NETR_MACMU reviewed Neurotrypsin (EC 3.4.21.-) (Serine protease 12) PRSS12 Macaca mulatta (Rhesus macaque) 875 exocytosis [GO:0006887] GO:0004252; GO:0005044; GO:0005576; GO:0005886; GO:0006887; GO:0030424 0 0 cd00190; PF00051;PF00530;PF00089; Q6DBY9 CHOYP_LOC100372809.1.1 m.39753 sp CHST1_DANRE 27.164 335 197 11 66 364 71 394 9.43E-15 78.6 CHST1_DANRE reviewed Carbohydrate sulfotransferase 1 (EC 2.8.2.21) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) chst1 zgc:100904 Danio rerio (Zebrafish) (Brachydanio rerio) 420 carbohydrate metabolic process [GO:0005975]; sulfur compound metabolic process [GO:0006790] GO:0000139; GO:0001517; GO:0005975; GO:0006790; GO:0016021; GO:0045130 0 0 0 PF00685; Q91WV7 CHOYP_SLC31.3.5 m.40781 sp SLC31_MOUSE 38.043 92 41 1 11 102 73 148 9.43E-12 63.5 SLC31_MOUSE reviewed "Neutral and basic amino acid transport protein rBAT (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein) (NBAT)" Slc3a1 Nbat Mus musculus (Mouse) 685 amino acid transport [GO:0006865]; carbohydrate metabolic process [GO:0005975] GO:0003824; GO:0005743; GO:0005774; GO:0005887; GO:0005975; GO:0006865; GO:0031526; GO:0070062 0 0 0 PF00128; Q969G6 CHOYP_TSN33.1.3 m.4159 sp RIFK_HUMAN 62.585 147 55 0 5 151 4 150 9.43E-67 203 RIFK_HUMAN reviewed Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase) RFK Homo sapiens (Human) 155 apoptotic process [GO:0006915]; FMN biosynthetic process [GO:0009398]; positive regulation of NAD(P)H oxidase activity [GO:0033864]; reactive oxygen species metabolic process [GO:0072593]; riboflavin biosynthetic process [GO:0009231]; riboflavin metabolic process [GO:0006771] GO:0005524; GO:0005737; GO:0005739; GO:0005829; GO:0006771; GO:0006915; GO:0008531; GO:0009231; GO:0009398; GO:0033864; GO:0046872; GO:0072593 PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. 0 0 PF01687; Q9JJN2 CHOYP_PHUM_PHUM190870.1.1 m.42647 sp ZFHX4_MOUSE 32.353 136 65 6 101 219 80 205 9.43E-09 58.9 ZFHX4_MOUSE reviewed Zinc finger homeobox protein 4 (Zinc finger homeodomain protein 4) (ZFH-4) Zfhx4 Zfh4 Mus musculus (Mouse) 3550 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0043565 0 0 0 PF00046; Q9NZN5 CHOYP_LOC100644321.7.7 m.61951 sp ARHGC_HUMAN 43.702 389 201 8 906 1279 755 1140 9.43E-80 295 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; A2AAJ9 CHOYP_TITIN.10.19 m.36746 sp OBSCN_MOUSE 32.8 125 79 2 17 138 89 211 9.44E-13 74.7 OBSCN_MOUSE reviewed Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK) Obscn Gm878 Mus musculus (Mouse) 8891 cell differentiation [GO:0030154]; mitophagy in response to mitochondrial depolarization [GO:0098779]; multicellular organism development [GO:0007275]; regulation of Rho protein signal transduction [GO:0035023] GO:0004674; GO:0005089; GO:0005524; GO:0005863; GO:0007275; GO:0030018; GO:0030154; GO:0030506; GO:0031430; GO:0031432; GO:0035023; GO:0098779 0 0 0 PF00041;PF07679;PF00612;PF00069;PF00621; A4IF63 CHOYP_LOC101060756.2.2 m.42417 sp TRIM2_BOVIN 34.906 106 65 3 18 120 627 731 9.44E-11 61.2 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; G5E8K5 CHOYP_SELD.2.2 m.60983 sp ANK3_MOUSE 23.75 400 252 11 284 679 310 660 9.44E-22 105 ANK3_MOUSE reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) Ank3 Mus musculus (Mouse) 1961 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of action potential [GO:0045760]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165]; synapse organization [GO:0050808] GO:0000281; GO:0005200; GO:0005737; GO:0005764; GO:0005886; GO:0005923; GO:0007009; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009925; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016020; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030424; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045202; GO:0045211; GO:0045296; GO:0045760; GO:0045838; GO:0050808; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; P56602 CHOYP_PPOX.1.1 m.45234 sp PPOX_BOVIN 37.339 466 268 11 28 478 4 460 9.44E-83 267 PPOX_BOVIN reviewed Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4) PPOX Bos taurus (Bovine) 477 protoporphyrinogen IX biosynthetic process [GO:0006782] GO:0004729; GO:0006782; GO:0031304 PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1. 0 0 PF01593; P83425 CHOYP_CBLN7.1.3 m.1030 sp HIP_MYTED 33.333 135 85 2 30 164 59 188 9.44E-14 69.7 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q03105 CHOYP_NEMVEDRAFT_V1G162114.1.2 m.7614 sp VATL_TORMA 85.135 148 22 0 6 153 7 154 9.44E-82 240 VATL_TORMA reviewed V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (15 kDa mediatophore protein) (Vacuolar proton pump 16 kDa proteolipid subunit) 0 Torpedo marmorata (Marbled electric ray) 154 ATP hydrolysis coupled proton transport [GO:0015991] GO:0005774; GO:0015078; GO:0015991; GO:0016021; GO:0033179 0 0 0 PF00137; Q0IH24 CHOYP_LOC100567951.1.1 m.67031 sp SPEF1_XENLA 62.921 89 33 0 1 89 24 112 9.44E-36 127 SPEF1_XENLA reviewed Sperm flagellar protein 1 spef1 clamp Xenopus laevis (African clawed frog) 229 0 GO:0005737; GO:0005930 0 0 0 PF06294; Q2KI97 CHOYP_LOC100373264.2.2 m.50341 sp GPR84_BOVIN 22.76 413 239 16 64 449 28 387 9.44E-13 73.2 GPR84_BOVIN reviewed G-protein coupled receptor 84 GPR84 Bos taurus (Bovine) 396 neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G-protein coupled receptor signaling pathway [GO:0007200] GO:0005887; GO:0007200; GO:0007218; GO:0008528; GO:0043235 0 0 0 PF00001; Q47879 CHOYP_NEMVEDRAFT_V1G225652.1.1 m.27923 sp ICEN_PANAN 38.158 228 130 3 4 228 205 424 9.44E-11 64.7 ICEN_PANAN reviewed Ice nucleation protein InaU inaU Pantoea ananas (Erwinia uredovora) 1034 0 GO:0009279; GO:0050825 0 0 0 PF00818; Q5R1T0 CHOYP_LOC100120677.1.1 m.16800 sp CAF1A_CHICK 30.657 137 66 4 18 150 716 827 9.44E-08 57 CAF1A_CHICK reviewed Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) CHAF1A CAIP150 RCJMB04_12f19 Gallus gallus (Chicken) 937 cell cycle [GO:0007049]; chromatin assembly [GO:0031497]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334] GO:0005634; GO:0006260; GO:0006281; GO:0006334; GO:0007049; GO:0031497; GO:0033186 0 0 0 PF15539;PF15557;PF12253; Q76IQ7 CHOYP_LOC663375.1.1 m.11969 sp TOX2_RAT 79.07 86 18 0 278 363 200 285 9.44E-35 140 TOX2_RAT reviewed TOX high mobility group box family member 2 (Granulosa cell HMG box protein 1) (GCX-1) Tox2 Gcx-1 Gcx1 Rattus norvegicus (Rat) 473 "female gonad development [GO:0008585]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to gonadotropin [GO:0034698]; transcription, DNA-templated [GO:0006351]" GO:0001085; GO:0003677; GO:0005634; GO:0006351; GO:0008585; GO:0034698; GO:0045944 0 0 0 PF00505; Q80V24 CHOYP_LOC101061667.1.1 m.8351 sp VGLL4_MOUSE 34.375 160 57 6 228 382 138 254 9.44E-12 68.9 VGLL4_MOUSE reviewed Transcription cofactor vestigial-like protein 4 (Vgl-4) Vgll4 Mus musculus (Mouse) 287 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF15245; Q864G0 CHOYP_SMP_045300.1.1 m.926 sp MSHR_LORTA 25.49 204 121 9 81 271 130 315 9.44E-06 50.1 MSHR_LORTA reviewed Melanocyte-stimulating hormone receptor (MSH-R) (Melanocortin receptor 1) (MC1-R) MC1R Loris tardigradus (Slender loris) 317 0 GO:0004980; GO:0005886; GO:0016021 0 0 0 PF00001; Q99NH0 CHOYP_LOC753709.44.44 m.64197 sp ANR17_MOUSE 29.74 538 309 16 132 656 204 685 9.44E-46 179 ANR17_MOUSE reviewed Ankyrin repeat domain-containing protein 17 (Ankyrin repeat domain-containing protein FOE) (Gene trap ankyrin repeat protein) Ankrd17 Foe Gtar Kiaa0697 Mus musculus (Mouse) 2603 blood vessel maturation [GO:0001955]; defense response to bacterium [GO:0042742]; endoderm development [GO:0007492]; innate immune response [GO:0045087]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of cell cycle [GO:0045787]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MDA-5 signaling pathway [GO:1900245]; positive regulation of RIG-I signaling pathway [GO:1900246]; regulation of DNA replication [GO:0006275] GO:0000785; GO:0001955; GO:0003682; GO:0005634; GO:0005737; GO:0006275; GO:0007492; GO:0016020; GO:0042742; GO:0043123; GO:0044822; GO:0045087; GO:0045787; GO:0051151; GO:1900087; GO:1900245; GO:1900246 0 0 0 PF12796;PF00013; D3YXG0 CHOYP_contig_040360 m.45756 sp HMCN1_MOUSE 23.383 201 119 7 30 224 2300 2471 9.45E-07 52.8 HMCN1_MOUSE reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) Hmcn1 Mus musculus (Mouse) 5634 0 GO:0005509; GO:0005576; GO:0005604; GO:0005938; GO:0030054; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q4R8T1 CHOYP_LOC585322.1.2 m.8217 sp EFCB6_MACFA 20.569 773 459 18 267 1018 7 645 9.45E-29 126 EFCB6_MACFA reviewed EF-hand calcium-binding domain-containing protein 6 (DJ-1-binding protein) (DJBP) (Fragment) EFCAB6 DJBP QtsA-11542 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 646 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005509; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF08976;PF13833; Q90Z04 CHOYP_PHUM_PHUM010640.1.1 m.56264 sp CDON_XENLA 26.754 228 147 8 100 323 712 923 9.45E-08 57.4 CDON_XENLA reviewed Cell adhesion molecule-related/down-regulated by oncogenes cdon cdo Xenopus laevis (African clawed frog) 1249 cell adhesion [GO:0007155]; embryonic morphogenesis [GO:0048598]; positive regulation of myoblast differentiation [GO:0045663]; regulation of neuron differentiation [GO:0045664]; smoothened signaling pathway [GO:0007224] GO:0005887; GO:0007155; GO:0007224; GO:0045663; GO:0045664; GO:0048598 0 0 0 PF00041;PF07679; Q96MM6 CHOYP_BRAFLDRAFT_57788.8.10 m.49717 sp HS12B_HUMAN 31.416 452 227 15 582 964 61 498 9.45E-52 197 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q9NWW9 CHOYP_BRAFLDRAFT_119296.8.16 m.36197 sp HRSL2_HUMAN 37.692 130 77 3 15 144 9 134 9.45E-20 84 HRSL2_HUMAN reviewed HRAS-like suppressor 2 (EC 2.3.1.-) (EC 3.1.1.-) HRASLS2 Homo sapiens (Human) 162 lipid catabolic process [GO:0016042] GO:0005737; GO:0016021; GO:0016042; GO:0016746; GO:0016787 0 0 0 PF04970; Q9Y426 CHOYP_LOC100367954.1.2 m.66390 sp CU025_HUMAN 30.263 304 185 10 101 397 238 521 9.45E-22 102 CU025_HUMAN reviewed C2 domain-containing protein 2 C2CD2 C21orf25 C21orf258 Homo sapiens (Human) 696 0 GO:0005576; GO:0005634; GO:0005829 0 0 0 PF00168; P32297 CHOYP_LOC100179754.1.1 m.51480 sp ACHA3_HUMAN 28.972 321 220 4 29 344 28 345 9.46E-41 154 ACHA3_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 NACHRA3 Homo sapiens (Human) 505 "activation of transmembrane receptor protein tyrosine kinase activity [GO:0007171]; behavioral response to nicotine [GO:0035095]; excitatory postsynaptic potential [GO:0060079]; heart development [GO:0007507]; ion transport [GO:0006811]; locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; protein heterooligomerization [GO:0051291]; regulation of acetylcholine secretion, neurotransmission [GO:0014056]; regulation of dendrite morphogenesis [GO:0048814]; regulation of membrane potential [GO:0042391]; regulation of smooth muscle contraction [GO:0006940]; response to drug [GO:0042493]; response to inorganic substance [GO:0010035]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]; synaptic transmission involved in micturition [GO:0060084]" GO:0004889; GO:0005886; GO:0005892; GO:0006811; GO:0006940; GO:0007165; GO:0007171; GO:0007271; GO:0007399; GO:0007507; GO:0007626; GO:0008144; GO:0010035; GO:0014056; GO:0014069; GO:0015276; GO:0015464; GO:0016021; GO:0030054; GO:0030425; GO:0035095; GO:0042166; GO:0042391; GO:0042493; GO:0043025; GO:0045211; GO:0048814; GO:0051291; GO:0060079; GO:0060084 0 0 0 PF02931;PF02932; Q04073 CHOYP_P3A2.3.3 m.34936 sp P3A2_STRPU 55.87 460 143 13 35 460 2 435 9.46E-151 440 P3A2_STRPU reviewed DNA-binding protein P3A2 0 Strongylocentrotus purpuratus (Purple sea urchin) 459 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355 0 0 0 PF10492;PF10491; Q14202 CHOYP_LOC100121687.1.1 m.57141 sp ZMYM3_HUMAN 40.871 597 278 11 1120 1707 829 1359 9.46E-128 438 ZMYM3_HUMAN reviewed Zinc finger MYM-type protein 3 (Zinc finger protein 261) ZMYM3 DXS6673E KIAA0385 ZNF261 Homo sapiens (Human) 1370 cytoskeleton organization [GO:0007010]; multicellular organism development [GO:0007275]; regulation of cell morphogenesis [GO:0022604] GO:0000981; GO:0003677; GO:0005654; GO:0005737; GO:0007010; GO:0007275; GO:0008270; GO:0022604 0 0 0 PF12012;PF06467; Q19673 CHOYP_TYRO2.5.5 m.43961 sp TYR3_CAEEL 36.066 305 168 10 104 390 108 403 9.46E-48 183 TYR3_CAEEL reviewed Putative tyrosinase-like protein tyr-3 tyr-3 F21C3.2 Caenorhabditis elegans 693 0 GO:0004497; GO:0046872 0 0 0 PF01549;PF00264; Q921L7 CHOYP_HEMK1.1.1 m.16146 sp HEMK1_MOUSE 36.97 330 191 5 4 319 11 337 9.46E-62 202 HEMK1_MOUSE reviewed HemK methyltransferase family member 1 (EC 2.1.1.-) Hemk1 Mus musculus (Mouse) 340 0 GO:0003676; GO:0005739; GO:0008276 0 0 0 PF05175; Q96JM4 CHOYP_LRRIQ1.1.1 m.24263 sp LRIQ1_HUMAN 31.12 1054 509 45 594 1499 734 1718 9.46E-92 333 LRIQ1_HUMAN reviewed Leucine-rich repeat and IQ domain-containing protein 1 LRRIQ1 KIAA1801 Homo sapiens (Human) 1722 0 0 0 0 0 PF00612; Q96MM6 CHOYP_BRAFLDRAFT_208293.17.20 m.62425 sp HS12B_HUMAN 40.952 105 57 2 1 100 145 249 9.46E-16 74.3 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99558 CHOYP_BRAFLDRAFT_84620.1.1 m.58919 sp M3K14_HUMAN 32.83 265 159 5 1019 1272 391 647 9.46E-37 155 M3K14_HUMAN reviewed Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) MAP3K14 NIK Homo sapiens (Human) 947 cellular response to mechanical stimulus [GO:0071260]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; immune response [GO:0006955]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004672; GO:0004674; GO:0004702; GO:0004704; GO:0004709; GO:0005524; GO:0005737; GO:0005829; GO:0006955; GO:0007249; GO:0016301; GO:0031295; GO:0033209; GO:0038061; GO:0043123; GO:0071260 0 0 0 PF00069; Q9BYK8 CHOYP_LOC100368178.1.3 m.36490 sp HELZ2_HUMAN 28.098 1630 970 50 138 1689 1111 2616 9.46E-160 545 HELZ2_HUMAN reviewed "Helicase with zinc finger domain 2 (ATP-dependent helicase PRIC285) (Helicase with zinc finger 2, transcriptional coactivator) (PPAR-alpha-interacting complex protein 285) (PPAR-gamma DNA-binding domain-interacting protein 1) (PDIP1) (PPAR-gamma DBD-interacting protein 1) (Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein) (EC 3.6.4.-)" HELZ2 KIAA1769 PRIC285 Homo sapiens (Human) 2649 "cellular lipid metabolic process [GO:0044255]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0004386; GO:0005524; GO:0005654; GO:0006351; GO:0016020; GO:0030374; GO:0044255; GO:0044822; GO:0045944; GO:0046872 0 0 0 0 Q9Y600 CHOYP_CSAD.1.1 m.40056 sp CSAD_HUMAN 50.769 455 218 4 75 527 43 493 9.46E-177 509 CSAD_HUMAN reviewed Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Cysteine-sulfinate decarboxylase) (Sulfinoalanine decarboxylase) CSAD CSD Homo sapiens (Human) 493 carboxylic acid metabolic process [GO:0019752]; taurine biosynthetic process [GO:0042412] GO:0004782; GO:0019752; GO:0030170; GO:0042412 PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2. 0 0 PF00282; O60931 CHOYP_LOC100187335.2.2 m.26256 sp CTNS_HUMAN 38.793 116 64 2 55 170 44 152 9.47E-15 73.9 CTNS_HUMAN reviewed Cystinosin CTNS Homo sapiens (Human) 367 adult walking behavior [GO:0007628]; ATP metabolic process [GO:0046034]; brain development [GO:0007420]; cellular amino acid metabolic process [GO:0006520]; cognition [GO:0050890]; glutathione metabolic process [GO:0006749]; grooming behavior [GO:0007625]; ion transport [GO:0006811]; L-cystine transport [GO:0015811]; lens development in camera-type eye [GO:0002088]; long-term memory [GO:0007616]; melanin biosynthetic process [GO:0042438]; transmembrane transport [GO:0055085]; visual learning [GO:0008542] GO:0002088; GO:0005764; GO:0005765; GO:0005770; GO:0005886; GO:0006520; GO:0006749; GO:0006811; GO:0007420; GO:0007616; GO:0007625; GO:0007628; GO:0008542; GO:0015184; GO:0015811; GO:0016021; GO:0042438; GO:0042470; GO:0043231; GO:0045111; GO:0046034; GO:0050890; GO:0055085; GO:0070062 0 0 0 PF04193; P43144 CHOYP_BRAFLDRAFT_126983.1.1 m.26641 sp ACHA9_RAT 33.402 488 302 9 36 520 10 477 9.47E-95 299 ACHA9_RAT reviewed Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) Chrna9 Acra9 Rattus norvegicus (Rat) 479 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; sensory perception of sound [GO:0007605]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005829; GO:0005892; GO:0007204; GO:0007271; GO:0007605; GO:0022848; GO:0030054; GO:0042166; GO:0042472; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; P43679 CHOYP_ACHB3.1.5 m.35008 sp ACHB3_CHICK 30.094 319 201 8 20 332 4 306 9.47E-34 134 ACHB3_CHICK reviewed Neuronal acetylcholine receptor subunit beta-3 CHRNB3 Gallus gallus (Chicken) 455 "cation transmembrane transport [GO:0098655]; neuromuscular synaptic transmission [GO:0007274]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0030054; GO:0035094; GO:0045211; GO:0098655 0 0 0 PF02931;PF02932; P59222 CHOYP_MEG11.13.25 m.46381 sp SREC2_MOUSE 37.853 177 101 7 189 365 228 395 9.47E-23 105 SREC2_MOUSE reviewed Scavenger receptor class F member 2 (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) Scarf2 Srec2 Mus musculus (Mouse) 833 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157] GO:0005044; GO:0005925; GO:0007157; GO:0016021 0 0 0 PF00053; Q03168 CHOYP_MGC89016.2.2 m.46317 sp ASPP_AEDAE 59.794 388 150 4 1 388 3 384 9.47E-172 487 ASPP_AEDAE reviewed Lysosomal aspartic protease (EC 3.4.23.-) AAEL006169 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 387 0 GO:0004190; GO:0005764 0 0 0 PF00026; Q5RJ80 CHOYP_C1QT4.5.5 m.66899 sp CAPR2_DANRE 30.534 131 80 5 65 191 785 908 9.47E-10 60.5 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q5XPI4 CHOYP_RN123.1.2 m.38896 sp RN123_HUMAN 39.032 620 335 14 28 631 37 629 9.47E-142 450 RN123_HUMAN reviewed E3 ubiquitin-protein ligase RNF123 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) RNF123 KPC1 FP1477 Homo sapiens (Human) 1314 protein ubiquitination [GO:0016567] GO:0005737; GO:0008270; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00622; Q61712 CHOYP_LOC100567790.1.1 m.8224 sp DNJC1_MOUSE 36.276 521 276 12 18 496 43 549 9.47E-95 301 DNJC1_MOUSE reviewed DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1) Dnajc1 Dnajl1 Mtj1 Mus musculus (Mouse) 552 protein folding [GO:0006457]; regulation of protein secretion [GO:0050708]; regulation of translation [GO:0006417] GO:0003677; GO:0005634; GO:0005783; GO:0005788; GO:0005789; GO:0005829; GO:0005886; GO:0006417; GO:0006457; GO:0016020; GO:0016021; GO:0031965; GO:0043022; GO:0050708; GO:0051087 0 0 cd06257; PF00226;PF00249; Q80TB8 CHOYP_AGAP_AGAP006478.1.1 m.44472 sp VAT1L_MOUSE 60.231 347 138 0 18 364 38 384 9.47E-159 455 VAT1L_MOUSE reviewed Synaptic vesicle membrane protein VAT-1 homolog-like (EC 1.-.-.-) Vat1l Kiaa1576 Mus musculus (Mouse) 417 0 GO:0008270; GO:0016491 0 0 0 PF08240; Q91ZV7 CHOYP_PXDC2.3.3 m.58663 sp PLDX1_MOUSE 36.53 438 225 9 86 512 77 472 9.47E-77 253 PLDX1_MOUSE reviewed Plexin domain-containing protein 1 (Tumor endothelial marker 7) Plxdc1 Tem7 Mus musculus (Mouse) 500 angiogenesis [GO:0001525]; spinal cord development [GO:0021510] GO:0001525; GO:0005737; GO:0005886; GO:0005923; GO:0016021; GO:0021510; GO:0030425; GO:0043025; GO:0043235 0 0 0 PF01437; Q9R0W9 CHOYP_LOC100376622.1.1 m.53967 sp ACHA6_MOUSE 30.592 304 202 6 40 335 42 344 9.47E-44 163 ACHA6_MOUSE reviewed Neuronal acetylcholine receptor subunit alpha-6 Chrna6 Nica6 Mus musculus (Mouse) 494 "membrane depolarization [GO:0051899]; neuromuscular synaptic transmission [GO:0007274]; regulation of dopamine secretion [GO:0014059]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0014059; GO:0030054; GO:0035094; GO:0045211; GO:0051899 0 0 0 PF02931;PF02932; Q9UKP5 CHOYP_ADAMTS12.1.2 m.29930 sp ATS6_HUMAN 30.179 1004 562 36 4 901 1 971 9.47E-118 402 ATS6_HUMAN reviewed A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAM-TS 6) (ADAM-TS6) (ADAMTS-6) (EC 3.4.24.-) ADAMTS6 Homo sapiens (Human) 1117 aorta development [GO:0035904]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976] GO:0003279; GO:0004222; GO:0005578; GO:0008237; GO:0008270; GO:0035904; GO:0060976 0 0 0 PF05986;PF01562;PF08686;PF01421;PF00090; Q9VCA8 CHOYP_LOC755521.23.28 m.55198 sp ANKHM_DROME 32.489 237 141 10 20 245 619 847 9.47E-18 86.3 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; A7Z063 CHOYP_LOC100376621.1.1 m.5270 sp WASH1_BOVIN 46.552 290 149 4 4 290 10 296 9.48E-80 253 WASH1_BOVIN reviewed WAS protein family homolog 1 WASH1 Bos taurus (Bovine) 471 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; dendritic cell antigen processing and presentation [GO:0002468]; endosomal transport [GO:0016197]; negative regulation of autophagy [GO:0010507]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; oocyte maturation [GO:0001556]; polar body extrusion after meiotic divisions [GO:0040038]; protein localization to cell surface [GO:0034394]; protein transport [GO:0015031]; regulation of immune response [GO:0050776]; regulation of protein ubiquitination [GO:0031396]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde transport, endosome to plasma membrane [GO:1990126]; spindle assembly involved in meiosis [GO:0090306]; T cell proliferation [GO:0042098]" GO:0001556; GO:0002468; GO:0005769; GO:0005770; GO:0005776; GO:0005814; GO:0010507; GO:0015031; GO:0016197; GO:0031083; GO:0031396; GO:0031410; GO:0031901; GO:0034314; GO:0034394; GO:0040038; GO:0042098; GO:0042147; GO:0043014; GO:0043553; GO:0050776; GO:0055037; GO:0055038; GO:0071203; GO:0090306; GO:1990126 0 0 0 PF11945; O70277 CHOYP_BRAFLDRAFT_69765.6.23 m.32740 sp TRIM3_RAT 21.633 245 179 4 21 254 488 730 9.48E-08 55.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O94813 CHOYP_CAOG_01265.1.1 m.46828 sp SLIT2_HUMAN 37.629 194 115 1 21 214 15 202 9.48E-32 125 SLIT2_HUMAN reviewed Slit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product] SLIT2 SLIL3 Homo sapiens (Human) 1529 apoptotic process involved in luteolysis [GO:0061364]; axon extension involved in axon guidance [GO:0048846]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to heparin [GO:0071504]; cellular response to hormone stimulus [GO:0032870]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; corticospinal neuron axon guidance through spinal cord [GO:0021972]; induction of negative chemotaxis [GO:0050929]; motor neuron axon guidance [GO:0008045]; negative chemotaxis [GO:0050919]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of cellular response to growth factor stimulus [GO:0090288]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of inflammatory response [GO:0050728]; negative regulation of lamellipodium assembly [GO:0010593]; negative regulation of leukocyte chemotaxis [GO:0002689]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of mononuclear cell migration [GO:0071676]; negative regulation of neutrophil chemotaxis [GO:0090024]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; negative regulation of small GTPase mediated signal transduction [GO:0051058]; negative regulation of smooth muscle cell chemotaxis [GO:0071672]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of vascular permeability [GO:0043116]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; response to cortisol [GO:0051414]; response to nutrient levels [GO:0031667]; retinal ganglion cell axon guidance [GO:0031290]; Roundabout signaling pathway [GO:0035385]; spinal cord development [GO:0021510]; ureteric bud development [GO:0001657] GO:0001657; GO:0001933; GO:0002042; GO:0002689; GO:0005095; GO:0005509; GO:0005576; GO:0005578; GO:0005615; GO:0005737; GO:0005886; GO:0007411; GO:0008045; GO:0008201; GO:0009986; GO:0010593; GO:0010596; GO:0014912; GO:0016020; GO:0021510; GO:0021836; GO:0021972; GO:0030308; GO:0030336; GO:0030837; GO:0031290; GO:0031667; GO:0032870; GO:0035385; GO:0042802; GO:0042803; GO:0043065; GO:0043116; GO:0043237; GO:0043394; GO:0043395; GO:0048495; GO:0048754; GO:0048846; GO:0050728; GO:0050772; GO:0050919; GO:0050929; GO:0051058; GO:0051414; GO:0061364; GO:0070062; GO:0070100; GO:0071504; GO:0071672; GO:0071676; GO:0090024; GO:0090027; GO:0090260; GO:0090288 0 0 0 PF00008;PF12661;PF00054;PF13855;PF01463;PF01462; P06731 CHOYP_BRAFLDRAFT_76648.2.2 m.44324 sp CEAM5_HUMAN 25.664 339 185 15 9 335 200 483 9.48E-11 68.2 CEAM5_HUMAN reviewed Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) CEACAM5 CEA Homo sapiens (Human) 702 homotypic cell-cell adhesion [GO:0034109]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of myotube differentiation [GO:0010832] GO:0005887; GO:0010832; GO:0016323; GO:0031225; GO:0034109; GO:0034235; GO:0042802; GO:0042803; GO:0043066; GO:0070062; GO:0071575; GO:2000811 0 0 0 PF13895;PF07686; Q21086 CHOYP_LOC100313691.1.1 m.290 sp GNL3_CAEEL 50.542 461 210 8 4 456 3 453 9.48E-151 448 GNL3_CAEEL reviewed Guanine nucleotide-binding protein-like 3 homolog (Nucleostemin-1) nst-1 K01C8.9 Caenorhabditis elegans 556 germ cell development [GO:0007281]; nematode larval development [GO:0002119]; regulation of cell proliferation [GO:0042127]; regulation of multicellular organism growth [GO:0040014]; ribosome biogenesis [GO:0042254] GO:0002119; GO:0003924; GO:0005525; GO:0005634; GO:0005654; GO:0005730; GO:0007281; GO:0040014; GO:0042127; GO:0042254 0 0 0 PF08701;PF01926; Q4LDE5 CHOYP_BRAFLDRAFT_92090.7.7 m.65930 sp SVEP1_HUMAN 30.321 343 199 14 95 421 332 650 9.48E-25 112 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q67UF5 CHOYP_PDI23.1.1 m.52419 sp PDI23_ORYSJ 38.961 77 39 2 52 122 170 244 9.48E-06 47.8 PDI23_ORYSJ reviewed Protein disulfide isomerase-like 2-3 (OsPDIL2-3) (EC 5.3.4.1) (Protein disulfide isomerase-like 5-1) (OsPDIL5-1) PDIL2-3 PDIL5-1 Os09g0451500 LOC_Os09g27830 OJ1163_C07.26 P0488D02.3 Oryza sativa subsp. japonica (Rice) 441 cell redox homeostasis [GO:0045454]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976] GO:0003756; GO:0005576; GO:0005783; GO:0006457; GO:0034976; GO:0045454 0 0 0 PF00085; Q6TFL4 CHOYP_LOC587597.1.1 m.9630 sp KLH24_HUMAN 25.287 435 307 4 130 549 58 489 9.48E-38 152 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q6V0I7 CHOYP_FAT1.4.4 m.63315 sp FAT4_HUMAN 28.399 993 613 45 1 962 2310 3235 9.48E-55 213 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q924H0 CHOYP_BRAFLDRAFT_64325.1.1 m.12882 sp NPFF2_MOUSE 31.438 299 185 8 25 311 38 328 9.48E-40 147 NPFF2_MOUSE reviewed Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide NPFF receptor) Npffr2 Gpr74 Npff2 Mus musculus (Mouse) 417 cellular response to hormone stimulus [GO:0032870]; chemical synaptic transmission [GO:0007268]; G-protein coupled receptor signaling pathway [GO:0007186]; regulation of adenylate cyclase activity [GO:0045761]; regulation of cAMP-dependent protein kinase activity [GO:2000479]; regulation of MAPK cascade [GO:0043408]; response to peptide [GO:1901652] GO:0005886; GO:0005887; GO:0007186; GO:0007268; GO:0008188; GO:0015629; GO:0032870; GO:0042277; GO:0043408; GO:0045761; GO:1901652; GO:2000479 0 0 0 PF00001; A4IGK3 CHOYP_LOC101167192.2.2 m.50797 sp CRBL2_XENTR 47.561 82 41 1 3 84 5 84 9.49E-20 86.7 CRBL2_XENTR reviewed cAMP-responsive element-binding protein-like 2 crebl2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 118 "cell differentiation [GO:0030154]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import [GO:0046326]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0005634; GO:0006351; GO:0030154; GO:0043565; GO:0045600; GO:0045893; GO:0046326; GO:0046889 0 0 0 PF07716; P29274 CHOYP_LOC577813.1.1 m.9908 sp AA2AR_HUMAN 38.192 343 194 4 3 331 4 342 9.49E-73 234 AA2AR_HUMAN reviewed Adenosine receptor A2a ADORA2A ADORA2 Homo sapiens (Human) 412 adenylate cyclase-modulating G-protein coupled receptor signaling pathway [GO:0007188]; apoptotic process [GO:0006915]; blood circulation [GO:0008015]; blood coagulation [GO:0007596]; cAMP biosynthetic process [GO:0006171]; cell-cell signaling [GO:0007267]; cellular defense response [GO:0006968]; cellular protein metabolic process [GO:0044267]; central nervous system development [GO:0007417]; inflammatory response [GO:0006954]; phagocytosis [GO:0006909]; positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [GO:0010579]; sensory perception [GO:0007600] GO:0001609; GO:0005886; GO:0005887; GO:0006171; GO:0006909; GO:0006915; GO:0006954; GO:0006968; GO:0007188; GO:0007267; GO:0007417; GO:0007596; GO:0007600; GO:0008015; GO:0010579; GO:0016020; GO:0019899; GO:0042802; GO:0044267 0 0 0 PF00001; Q5F2F2 CHOYP_LOC100367864.3.3 m.36451 sp ABH15_MOUSE 36.556 331 193 5 66 382 88 415 9.49E-59 201 ABH15_MOUSE reviewed Protein ABHD15 (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) Abhd15 Mus musculus (Mouse) 459 0 GO:0005576; GO:0016020; GO:0016787 0 0 0 0 Q6R7L5 CHOYP_OSHV1_GP010.2.2 m.30533 sp Y008_OSHVF 100 176 0 0 1 176 1 176 9.49E-130 369 Y008_OSHVF reviewed Uncharacterized protein ORF8 ORF8 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 319 0 0 0 0 0 0 Q6R891 CHOYP_NEB1.1.1 m.35802 sp NEB2_MOUSE 40.377 478 179 13 793 1265 432 808 9.49E-82 291 NEB2_MOUSE reviewed Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) Ppp1r9b Mus musculus (Mouse) 817 actin cytoskeleton organization [GO:0030036]; actin filament depolymerization [GO:0030042]; actin filament organization [GO:0007015]; aging [GO:0007568]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to drug [GO:0035690]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estradiol stimulus [GO:0071392]; cellular response to light stimulus [GO:0071482]; cellular response to morphine [GO:0071315]; cellular response to peptide [GO:1901653]; cerebral cortex development [GO:0021987]; dendrite development [GO:0016358]; developmental process involved in reproduction [GO:0003006]; filopodium assembly [GO:0046847]; hippocampus development [GO:0021766]; learning [GO:0007612]; male mating behavior [GO:0060179]; modulation of synaptic transmission [GO:0050804]; negative regulation of cell growth [GO:0030308]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of protein localization to actin cortical patch [GO:1904372]; protein localization to actin cytoskeleton [GO:1903119]; protein localization to cell periphery [GO:1990778]; regulation of cell proliferation [GO:0042127]; regulation of opioid receptor signaling pathway [GO:2000474]; regulation of protein phosphorylation [GO:0001932]; reproductive system development [GO:0061458]; response to amphetamine [GO:0001975]; response to antidepressant [GO:0036276]; response to clozapine [GO:0097338]; response to immobilization stress [GO:0035902]; response to kainic acid [GO:1904373]; response to L-phenylalanine derivative [GO:1904386]; response to nicotine [GO:0035094]; response to prostaglandin E [GO:0034695]; response to steroid hormone [GO:0048545] GO:0001932; GO:0001975; GO:0003006; GO:0003779; GO:0004672; GO:0004864; GO:0005654; GO:0005737; GO:0005886; GO:0005912; GO:0007015; GO:0007568; GO:0007612; GO:0014069; GO:0016358; GO:0016477; GO:0019722; GO:0021766; GO:0021987; GO:0030027; GO:0030036; GO:0030042; GO:0030175; GO:0030308; GO:0030425; GO:0030426; GO:0030864; GO:0032515; GO:0032587; GO:0034695; GO:0035094; GO:0035690; GO:0035902; GO:0036276; GO:0042127; GO:0043025; GO:0044326; GO:0044327; GO:0046847; GO:0048545; GO:0050804; GO:0051015; GO:0060179; GO:0061458; GO:0071315; GO:0071364; GO:0071392; GO:0071482; GO:0090004; GO:0097338; GO:1901653; GO:1903119; GO:1904372; GO:1904373; GO:1904386; GO:1990778; GO:1990780; GO:2000474 0 0 0 PF00595; Q6ZRF8 CHOYP_LOC100373444.25.79 m.28516 sp RN207_HUMAN 26.087 207 124 8 29 221 114 305 9.49E-14 77 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q9TW28 CHOYP_LOC100693730.1.1 m.21344 sp MYOM_DICDI 30.769 208 136 2 806 1013 1383 1582 9.49E-21 103 MYOM_DICDI reviewed Myosin-M heavy chain (RhoGEF domain-containing protein myoM) myoM racGEF DDB_G0292262 Dictyostelium discoideum (Slime mold) 1737 hyperosmotic response [GO:0006972]; hypotonic response [GO:0006971]; pseudopodium organization [GO:0031268]; regulation of Rac protein signal transduction [GO:0035020]; regulation of Rho protein signal transduction [GO:0035023] GO:0000146; GO:0005524; GO:0005737; GO:0006971; GO:0006972; GO:0016461; GO:0016887; GO:0030676; GO:0031268; GO:0035020; GO:0035023; GO:0042995; GO:0051015 0 0 0 PF00063;PF00169;PF00621; O15145 CHOYP_GPN3.1.2 m.6649 sp ARPC3_HUMAN 72.316 177 47 2 1 175 1 177 9.50E-97 280 ARPC3_HUMAN reviewed Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) ARPC3 ARC21 Homo sapiens (Human) 178 Arp2/3 complex-mediated actin nucleation [GO:0034314]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; movement of cell or subcellular component [GO:0006928] GO:0005200; GO:0005829; GO:0005885; GO:0005925; GO:0006928; GO:0015629; GO:0016020; GO:0030027; GO:0034314; GO:0038096; GO:0048013; GO:0070062 0 0 0 PF04062; O43736 CHOYP_LOC100368591.1.1 m.44385 sp ITM2A_HUMAN 29.741 232 112 10 35 262 35 219 9.50E-15 76.3 ITM2A_HUMAN reviewed Integral membrane protein 2A (Protein E25) ITM2A UNQ603/PRO1189 Homo sapiens (Human) 263 negative regulation of amyloid precursor protein biosynthetic process [GO:0042985]; nervous system development [GO:0007399] GO:0001540; GO:0005794; GO:0005886; GO:0007399; GO:0016021; GO:0042985; GO:0070062 0 0 0 PF04089; O75382 CHOYP_LOC100373444.70.79 m.60541 sp TRIM3_HUMAN 28.333 120 81 3 438 554 627 744 9.50E-07 55.5 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P61805 CHOYP_LOC578220.1.2 m.16983 sp DAD1_RAT 73.214 112 30 0 42 153 2 113 9.50E-58 178 DAD1_RAT reviewed Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (EC 2.4.99.18) (Defender against cell death 1) (DAD-1) Dad1 Rattus norvegicus (Rat) 113 apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; negative regulation of apoptotic process [GO:0043066]; protein glycosylation [GO:0006486]; response to drug [GO:0042493]; response to nutrient [GO:0007584] GO:0001824; GO:0004579; GO:0006486; GO:0006915; GO:0007584; GO:0008250; GO:0016021; GO:0042493; GO:0043066; GO:0070062 PATHWAY: Protein modification; protein glycosylation. 0 0 PF02109; Q54GB3 CHOYP_LOC100635245.3.4 m.44747 sp SYBB_DICDI 37.778 90 55 1 34 123 10 98 9.50E-12 60.5 SYBB_DICDI reviewed Synaptobrevin-B sybB DDB_G0290363 Dictyostelium discoideum (Slime mold) 101 exocytosis [GO:0006887]; vesicle fusion [GO:0006906] GO:0000149; GO:0005484; GO:0006887; GO:0006906; GO:0016021; GO:0030658; GO:0031201 0 0 0 PF00957; Q6ZNE9 CHOYP_BRAFLDRAFT_120281.1.1 m.62075 sp RUFY4_HUMAN 31.126 151 94 5 25 173 32 174 9.50E-07 54.7 RUFY4_HUMAN reviewed RUN and FYVE domain-containing protein 4 RUFY4 Homo sapiens (Human) 571 0 GO:0046872 0 0 0 PF02759; Q6ZV65 CHOYP_LOC100889336.1.1 m.18328 sp FA47E_HUMAN 33.108 148 92 3 26 173 16 156 9.50E-15 75.1 FA47E_HUMAN reviewed Protein FAM47E FAM47E Homo sapiens (Human) 393 0 0 0 0 0 PF14642; Q8K3K9 CHOYP_LOC100616953.4.4 m.66570 sp GIMA4_RAT 35.404 161 99 4 28 186 32 189 9.50E-23 96.7 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q8K4F6 CHOYP_NEMVEDRAFT_V1G240471.1.1 m.10922 sp NSUN5_MOUSE 38.991 436 251 6 24 452 17 444 9.50E-88 283 NSUN5_MOUSE reviewed Probable 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein homolog) Nsun5 Wbscr20 Wbscr20a Mus musculus (Mouse) 465 rRNA base methylation [GO:0070475] GO:0005634; GO:0005730; GO:0008173; GO:0008757; GO:0044822; GO:0070475 0 0 0 PF01189; Q9BRZ2 CHOYP_LOC100374741.79.83 m.63217 sp TRI56_HUMAN 25.17 294 166 11 140 412 21 281 9.50E-14 79 TRI56_HUMAN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (RING finger protein 109) (Tripartite motif-containing protein 56) TRIM56 RNF109 Homo sapiens (Human) 755 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; regulation of type I interferon production [GO:0032479]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0005829; GO:0008270; GO:0016874; GO:0032479; GO:0032608; GO:0034340; GO:0044822; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; Q9BSF4 CHOYP_LOC100368023.1.1 m.14890 sp CS052_HUMAN 30.909 165 114 0 35 199 24 188 9.50E-30 114 CS052_HUMAN reviewed Uncharacterized protein C19orf52 C19orf52 Homo sapiens (Human) 260 0 0 0 0 0 PF10171; Q9ESN6 CHOYP_BRAFLDRAFT_87297.1.1 m.60180 sp TRIM2_MOUSE 26.708 161 111 3 11 169 578 733 9.50E-08 54.3 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_LOC100374741.81.83 m.64711 sp TRIM2_MOUSE 27.746 173 118 4 340 510 536 703 9.50E-11 68.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H8L6 CHOYP_CBLN13.2.9 m.25580 sp MMRN2_HUMAN 32.143 112 73 2 93 204 822 930 9.50E-10 61.6 MMRN2_HUMAN reviewed Multimerin-2 (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit) MMRN2 EMILIN3 Homo sapiens (Human) 949 angiogenesis [GO:0001525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948] GO:0001525; GO:0005604; GO:0005615; GO:0030948; GO:0031012; GO:0070062; GO:0090051 0 0 0 PF00386;PF07546; B6LS00 CHOYP_U728.1.1 m.63184 sp U728_BRAFL 58.696 92 38 0 27 118 1 92 9.51E-36 120 U728_BRAFL reviewed UPF0728 protein BRAFLDRAFT_270831 Branchiostoma floridae (Florida lancelet) (Amphioxus) 92 0 0 0 0 0 PF15092; P34457 CHOYP_CBG07229.1.1 m.14243 sp YMD3_CAEEL 41.346 104 58 2 95 196 1 103 9.51E-17 79.3 YMD3_CAEEL reviewed Putative uncharacterized transposon-derived protein F54H12.3 F54H12.3 Caenorhabditis elegans 286 DNA integration [GO:0015074] GO:0003676; GO:0015074 0 0 0 PF00665; Q4V842 CHOYP_GPTC4.1.2 m.20385 sp GPTC4_XENLA 51.515 198 91 4 5 197 13 210 9.51E-57 187 GPTC4_XENLA reviewed G patch domain-containing protein 4 gpatch4 gpatc4 Xenopus laevis (African clawed frog) 324 0 GO:0003676 0 0 0 PF01585; Q61164 CHOYP_ZSCA2.1.2 m.9204 sp CTCF_MOUSE 26.087 345 192 9 720 1060 266 551 9.51E-24 112 CTCF_MOUSE reviewed Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog) Ctcf Mus musculus (Mouse) 736 "chromosome segregation [GO:0007059]; covalent chromatin modification [GO:0016569]; DNA methylation [GO:0006306]; dosage compensation by inactivation of X chromosome [GO:0009048]; maintenance of DNA methylation [GO:0010216]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome positioning [GO:0016584]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of gene expression, epigenetic [GO:0040029]; regulation of gene expression by genetic imprinting [GO:0006349]; regulation of histone acetylation [GO:0035065]; regulation of histone methylation [GO:0031060]; regulation of molecular function, epigenetic [GO:0040030]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000122; GO:0000775; GO:0000793; GO:0000978; GO:0001078; GO:0001228; GO:0003677; GO:0003682; GO:0003700; GO:0005634; GO:0005654; GO:0005730; GO:0006306; GO:0006349; GO:0006355; GO:0007059; GO:0009048; GO:0010216; GO:0010628; GO:0010629; GO:0016569; GO:0016584; GO:0031060; GO:0035065; GO:0040029; GO:0040030; GO:0043035; GO:0043565; GO:0044212; GO:0045892; GO:0045893; GO:0046872 0 0 0 0 Q6UX73 CHOYP_BRAFLDRAFT_66659.2.2 m.5671 sp CP089_HUMAN 28.302 159 111 3 27 184 37 193 9.51E-14 72.8 CP089_HUMAN reviewed UPF0764 protein C16orf89 C16orf89 UNQ904/PRO1925 Homo sapiens (Human) 402 0 GO:0005829; GO:0016020; GO:0042803; GO:0070062 0 0 0 PF15882; Q7ZXV8 CHOYP_ZN207.1.1 m.6909 sp ZN207_XENLA 43.99 391 164 14 1 348 1 379 9.51E-69 226 ZN207_XENLA reviewed BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (xBuGZ) (Zinc finger protein 207) znf207 bugz Xenopus laevis (African clawed frog) 452 attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint [GO:0007094]; protein stabilization [GO:0050821]; regulation of chromosome segregation [GO:0051983] GO:0000070; GO:0000776; GO:0000777; GO:0001578; GO:0005634; GO:0005737; GO:0005819; GO:0005874; GO:0007094; GO:0008017; GO:0008608; GO:0046785; GO:0046872; GO:0050821; GO:0051301; GO:0051983; GO:0090307; GO:1990047 0 0 0 0 Q8K2P6 CHOYP_RFESD.1.1 m.35722 sp RFESD_MOUSE 43.182 132 75 0 15 146 20 151 9.51E-36 124 RFESD_MOUSE reviewed Rieske domain-containing protein Rfesd Mus musculus (Mouse) 157 nitrate assimilation [GO:0042128] GO:0008942; GO:0042128; GO:0046872; GO:0051537 0 0 0 PF13806; O60343 CHOYP_SI_CH211-222G23.4.1.1 m.37661 sp TBCD4_HUMAN 29.917 361 224 8 69 412 166 514 9.52E-32 131 TBCD4_HUMAN reviewed TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) TBC1D4 AS160 KIAA0603 Homo sapiens (Human) 1298 activation of GTPase activity [GO:0090630]; cellular response to insulin stimulus [GO:0032869]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; negative regulation of vesicle fusion [GO:0031339]; regulation of vesicle fusion [GO:0031338]; vesicle-mediated transport [GO:0016192] GO:0005096; GO:0005622; GO:0005737; GO:0006886; GO:0012505; GO:0016192; GO:0017137; GO:0030659; GO:0031338; GO:0031339; GO:0032869; GO:0061024; GO:0070062; GO:0090630 0 0 0 PF11830;PF00640;PF00566; P02721 CHOYP_NEMVEDRAFT_V1G201552.6.6 m.64592 sp ATP5J_BOVIN 36.735 98 50 5 24 121 18 103 9.52E-10 56.2 ATP5J_BOVIN reviewed "ATP synthase-coupling factor 6, mitochondrial (ATPase subunit F6)" ATP5J Bos taurus (Bovine) 108 ATP synthesis coupled proton transport [GO:0015986]; substantia nigra development [GO:0021762] GO:0000276; GO:0005753; GO:0015078; GO:0015986; GO:0016887; GO:0021762 0 0 0 PF05511; P04792 CHOYP_RNP1B.1.1 m.59889 sp HSPB1_HUMAN 36.145 83 52 1 46 127 89 171 9.52E-09 54.7 HSPB1_HUMAN reviewed Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) HSPB1 HSP27 HSP28 Homo sapiens (Human) 205 cellular response to vascular endothelial growth factor stimulus [GO:0035924]; intracellular signal transduction [GO:0035556]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; negative regulation of protein kinase activity [GO:0006469]; platelet aggregation [GO:0070527]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell chemotaxis [GO:2001028]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of interleukin-1 beta production [GO:0032731]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; regulation of autophagy [GO:0010506]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mRNA stability [GO:0043488]; regulation of translational initiation [GO:0006446]; response to unfolded protein [GO:0006986]; response to virus [GO:0009615]; retina homeostasis [GO:0001895]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0000502; GO:0001895; GO:0005080; GO:0005615; GO:0005634; GO:0005737; GO:0005819; GO:0005829; GO:0005856; GO:0005886; GO:0005925; GO:0006446; GO:0006469; GO:0006928; GO:0006986; GO:0008426; GO:0009615; GO:0010506; GO:0019901; GO:0030018; GO:0031012; GO:0032731; GO:0035556; GO:0035924; GO:0038033; GO:0042535; GO:0042802; GO:0043066; GO:0043122; GO:0043130; GO:0043488; GO:0043536; GO:0044822; GO:0045766; GO:0048010; GO:0070062; GO:0070527; GO:1902176; GO:2001028 0 0 0 PF00011; P24733 CHOYP_ISCW_ISCW001340.1.1 m.1981 sp MYS_ARGIR 49.02 306 116 7 1 286 657 942 9.52E-67 229 MYS_ARGIR reviewed "Myosin heavy chain, striated muscle" 0 Argopecten irradians (Bay scallop) (Aequipecten irradians) 1938 0 GO:0003774; GO:0005524; GO:0030016; GO:0032982 0 0 0 PF00063;PF02736;PF01576; Q8IWZ3 CHOYP_BRAFLDRAFT_65562.1.1 m.14266 sp ANKH1_HUMAN 34.921 189 116 5 801 984 376 562 9.52E-19 96.3 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q96RW7 CHOYP_KLH12.3.3 m.66334 sp HMCN1_HUMAN 38.801 317 176 6 75 382 4505 4812 9.52E-64 224 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9P055 CHOYP_LOC101156369.1.1 m.23650 sp JKAMP_HUMAN 49.667 300 138 4 11 302 24 318 9.52E-99 296 JKAMP_HUMAN reviewed JNK1/MAPK8-associated membrane protein (JKAMP) (JNK1-associated membrane protein) (JAMP) (Medulloblastoma antigen MU-MB-50.4) JKAMP C14orf100 JAMP CDA06 HSPC213 HSPC327 Homo sapiens (Human) 326 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; response to unfolded protein [GO:0006986] GO:0005789; GO:0006986; GO:0016021; GO:0030433; GO:0031625 0 0 0 PF05571; P16257 CHOYP_MITF.2.3 m.25840 sp TSPO_RAT 43.21 162 91 1 49 209 1 162 9.53E-45 149 TSPO_RAT reviewed Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR) Tspo Bzrp Mbr Rattus norvegicus (Rat) 169 adrenal gland development [GO:0030325]; aging [GO:0007568]; behavioral response to pain [GO:0048266]; cellular hypotonic response [GO:0071476]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; contact inhibition [GO:0060242]; establishment of protein localization to mitochondrion [GO:0072655]; glial cell migration [GO:0008347]; ion transport [GO:0006811]; lipid transport [GO:0006869]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of mitophagy [GO:1903147]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tumor necrosis factor production [GO:0032720]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of necrotic cell death [GO:0010940]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of steroid biosynthetic process [GO:0050810]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to manganese ion [GO:0010042]; response to pain [GO:0048265]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to vitamin B1 [GO:0010266]; steroid biosynthetic process [GO:0006694] GO:0005497; GO:0005739; GO:0005741; GO:0006694; GO:0006811; GO:0006821; GO:0006869; GO:0007568; GO:0008347; GO:0008503; GO:0010042; GO:0010266; GO:0010940; GO:0014012; GO:0016021; GO:0030325; GO:0031397; GO:0031965; GO:0032570; GO:0032720; GO:0033574; GO:0042493; GO:0043065; GO:0045019; GO:0048265; GO:0048266; GO:0048678; GO:0050810; GO:0051901; GO:0051928; GO:0060242; GO:0060252; GO:0060253; GO:0070062; GO:0071222; GO:0071294; GO:0071476; GO:0072655; GO:0072656; GO:1903147; GO:1903579; GO:2000379 0 0 0 PF03073; P42325 CHOYP_NCAH.1.5 m.8670 sp NCAH_DROME 56.831 183 78 1 1 182 1 183 9.53E-72 218 NCAH_DROME reviewed Neurocalcin homolog (DrosNCa) Nca CG7641 Drosophila melanogaster (Fruit fly) 190 0 GO:0005509 0 0 0 PF00036;PF13499; Q5BJI6 CHOYP_LOC100377470.1.1 m.4812 sp POP5_DANRE 37.5 144 82 4 26 162 5 147 9.53E-25 97.1 POP5_DANRE reviewed Ribonuclease P/MRP protein subunit POP5 (EC 3.1.26.5) pop5 zgc:110616 Danio rerio (Zebrafish) (Brachydanio rerio) 169 protein lipoylation [GO:0009249]; tRNA processing [GO:0008033] GO:0004526; GO:0005730; GO:0008033; GO:0009249 0 0 0 PF01900; Q86TX2 CHOYP_BRAFLDRAFT_72274.1.2 m.5307 sp ACOT1_HUMAN 36.881 404 238 7 16 411 16 410 9.53E-85 268 ACOT1_HUMAN reviewed Acyl-coenzyme A thioesterase 1 (Acyl-CoA thioesterase 1) (EC 3.1.2.2) (CTE-I) (CTE-Ib) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) ACOT1 CTE1 Homo sapiens (Human) 421 acyl-CoA metabolic process [GO:0006637]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; very long-chain fatty acid metabolic process [GO:0000038] GO:0000038; GO:0001676; GO:0005829; GO:0006637; GO:0016290; GO:0035338; GO:0047617; GO:0052689 0 0 0 PF08840;PF04775; Q8K310 CHOYP_RBM20.2.2 m.36854 sp MATR3_MOUSE 58.333 48 20 0 75 122 783 830 9.53E-14 72 MATR3_MOUSE reviewed Matrin-3 Matr3 Mus musculus (Mouse) 846 heart valve development [GO:0003170]; posttranscriptional regulation of gene expression [GO:0010608]; ventricular septum development [GO:0003281] GO:0000166; GO:0003170; GO:0003281; GO:0005634; GO:0005654; GO:0008270; GO:0010608; GO:0016020; GO:0016363; GO:0044822 0 0 0 0 Q8VI02 CHOYP_PP4R1.1.1 m.11682 sp PP4R1_RAT 39.309 608 340 8 451 1035 338 939 9.53E-126 410 PP4R1_RAT reviewed Serine/threonine-protein phosphatase 4 regulatory subunit 1 Ppp4r1 Rattus norvegicus (Rat) 951 signal transduction [GO:0007165] GO:0007165; GO:0030289; GO:0030362 0 0 0 PF02985; Q969F9 CHOYP_HPS3.1.1 m.10484 sp HPS3_HUMAN 29.237 236 138 8 1 224 1 219 9.53E-22 97.4 HPS3_HUMAN reviewed Hermansky-Pudlak syndrome 3 protein HPS3 Homo sapiens (Human) 1004 organelle organization [GO:0006996]; pigmentation [GO:0043473] GO:0006996; GO:0031084; GO:0043473 0 0 0 PF14763;PF14762;PF14761; Q9V785 CHOYP_AGAP_AGAP011293.1.1 m.9041 sp 3BP5H_DROME 46.332 259 133 3 39 292 8 265 9.53E-62 212 3BP5H_DROME reviewed SH3 domain-binding protein 5 homolog (Protein parcase) pcs CG7761 Drosophila melanogaster (Fruit fly) 477 anterior/posterior pattern specification [GO:0009952]; female germline ring canal formation [GO:0007301]; intracellular signal transduction [GO:0035556]; mesoderm development [GO:0007498]; muscle cell fate specification [GO:0042694]; muscle organ development [GO:0007517]; muscle organ morphogenesis [GO:0048644]; negative regulation of protein tyrosine kinase activity [GO:0061099] GO:0004860; GO:0005737; GO:0005886; GO:0007301; GO:0007498; GO:0007517; GO:0009952; GO:0017124; GO:0035556; GO:0042694; GO:0048644; GO:0061099 0 0 0 PF05276; O43301 CHOYP_BRAFLDRAFT_240194.2.2 m.38281 sp HS12A_HUMAN 39.205 176 99 4 9 183 56 224 9.54E-32 123 HS12A_HUMAN reviewed Heat shock 70 kDa protein 12A HSPA12A KIAA0417 Homo sapiens (Human) 675 0 GO:0005524; GO:0070062 0 0 0 0 O57525 CHOYP_CP17A.1.2 m.39873 sp CP17A_RANDY 31.983 469 296 7 42 495 49 509 9.54E-70 234 CP17A_RANDY reviewed "Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 4.1.2.30) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)" CYP17A1 CYP17 Rana dybowskii (Dybovsky's frog) (Korean brown frog) 519 sex differentiation [GO:0007548]; steroid biosynthetic process [GO:0006694] GO:0004508; GO:0005506; GO:0006694; GO:0007548; GO:0016020; GO:0020037; GO:0047442 PATHWAY: Lipid metabolism; steroid biosynthesis. 0 0 PF00067; O89026 CHOYP_LOC100473711.1.1 m.33770 sp ROBO1_MOUSE 22.642 477 285 24 19 439 193 641 9.54E-11 68.6 ROBO1_MOUSE reviewed Roundabout homolog 1 Robo1 Dutt1 Mus musculus (Mouse) 1612 activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; axon guidance [GO:0007411]; axon midline choice point recognition [GO:0016199]; cell migration involved in sprouting angiogenesis [GO:0002042]; chemorepulsion involved in postnatal olfactory bulb interneuron migration [GO:0021836]; coronary vasculature development [GO:0060976]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; mammary duct terminal end bud growth [GO:0060763]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of negative chemotaxis [GO:0050925]; olfactory bulb interneuron development [GO:0021891]; positive regulation of axonogenesis [GO:0050772]; positive regulation of Rho protein signal transduction [GO:0035025]; Roundabout signaling pathway [GO:0035385]; ventricular septum development [GO:0003281] GO:0002042; GO:0003281; GO:0005737; GO:0005886; GO:0006919; GO:0007156; GO:0007411; GO:0007507; GO:0008285; GO:0009986; GO:0016021; GO:0016199; GO:0021836; GO:0021891; GO:0030275; GO:0030336; GO:0030673; GO:0033600; GO:0035025; GO:0035385; GO:0042802; GO:0050772; GO:0050925; GO:0060763; GO:0060976; GO:0070100 0 0 0 PF00041;PF07679; Q01484 CHOYP_TVAG_168010.35.45 m.58503 sp ANK2_HUMAN 32.219 329 212 3 245 563 104 431 9.54E-46 177 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q91WL8 CHOYP_LOC763133.1.3 m.3794 sp WWOX_MOUSE 36.246 309 168 7 14 315 123 409 9.54E-49 171 WWOX_MOUSE reviewed WW domain-containing oxidoreductase (EC 1.1.1.-) Wwox Wox1 Mus musculus (Mouse) 414 cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; skeletal system morphogenesis [GO:0048705]; Wnt signaling pathway [GO:0016055] GO:0001649; GO:0005634; GO:0005737; GO:0005739; GO:0005794; GO:0005829; GO:0005886; GO:0005902; GO:0016055; GO:0016491; GO:0019899; GO:0030178; GO:0045944; GO:0048705; GO:0071560; GO:0072332; GO:0090575; GO:0097191; GO:2001238; GO:2001241 0 0 0 PF00106;PF00397; Q99M80 CHOYP_PTPRT.43.45 m.62158 sp PTPRT_MOUSE 33.718 347 187 7 100 406 762 1105 9.54E-51 187 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ULJ7 CHOYP_LOC589750.2.5 m.10773 sp ANR50_HUMAN 28.656 506 347 7 84 586 493 987 9.54E-48 186 ANR50_HUMAN reviewed Ankyrin repeat domain-containing protein 50 ANKRD50 KIAA1223 Homo sapiens (Human) 1429 "protein transport [GO:0015031]; retrograde transport, endosome to plasma membrane [GO:1990126]" GO:0005768; GO:0015031; GO:1990126 0 0 0 PF00023;PF12796; O15990 CHOYP_KARG.1.11 m.2034 sp KARG_LIOJA 65.283 265 91 1 1 264 1 265 9.55E-124 360 KARG_LIOJA reviewed Arginine kinase (AK) (EC 2.7.3.3) 0 Liolophura japonica (Chiton) (Acanthopleura japonica) 349 0 GO:0004054; GO:0005524 0 0 0 PF00217;PF02807; O57590 CHOYP_LOC100373170.1.1 m.10994 sp SURF4_TAKRU 73.783 267 70 0 4 270 3 269 9.55E-140 396 SURF4_TAKRU reviewed Surfeit locus protein 4 surf4 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) 269 0 GO:0005789; GO:0016021 0 0 0 PF02077; P80109 CHOYP_LOC590298.1.3 m.2714 sp PHLD_BOVIN 23.944 213 148 7 32 240 636 838 9.55E-11 64.7 PHLD_BOVIN reviewed Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D) GPLD1 PIGPLD Bos taurus (Bovine) 839 cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytolysis [GO:0045919]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633] GO:0001503; GO:0002042; GO:0002062; GO:0002430; GO:0004621; GO:0005578; GO:0005615; GO:0005737; GO:0006507; GO:0008285; GO:0008286; GO:0009749; GO:0010595; GO:0010694; GO:0010867; GO:0010897; GO:0010907; GO:0010983; GO:0017080; GO:0032869; GO:0034364; GO:0035690; GO:0035774; GO:0043065; GO:0043231; GO:0045919; GO:0046470; GO:0051044; GO:0051047; GO:0070633; GO:0071277; GO:0071397; GO:0071401; GO:0071467; GO:1900076 0 0 0 PF01839;PF00882; Q0V8S9 CHOYP_NEMVEDRAFT_V1G124069.1.1 m.26999 sp CNTP5_CHICK 41.135 141 76 4 117 251 35 174 9.55E-21 94.4 CNTP5_CHICK reviewed Contactin-associated protein-like 5 (Cell recognition molecule Caspr5) CNTNAP5 CASPR5 Gallus gallus (Chicken) 1305 cell adhesion [GO:0007155] GO:0007155; GO:0016021 0 0 0 PF00008;PF00754;PF00054;PF02210; Q1NZ26 CHOYP_LOC100649237.1.1 m.15690 sp YSMU_CAEEL 48.649 74 37 1 4 77 11 83 9.55E-16 73.9 YSMU_CAEEL reviewed "Uncharacterized protein F13E9.13, mitochondrial" F13E9.13 Caenorhabditis elegans 277 metabolic process [GO:0008152] GO:0003824; GO:0005739; GO:0008152 0 0 0 PF03437; Q24157 CHOYP_LOC100648600.1.1 m.10927 sp BRN_DROME 30.405 296 189 8 96 381 28 316 9.55E-36 136 BRN_DROME reviewed "Beta-1,3-galactosyltransferase brn (EC 2.4.1.62) (Brainiac protein) (Neurogenic secreted-signaling protein brn)" brn CG4934 Drosophila melanogaster (Fruit fly) 325 border follicle cell migration [GO:0007298]; germarium-derived egg chamber formation [GO:0007293]; glycosphingolipid biosynthetic process [GO:0006688]; maintenance of polarity of follicular epithelium [GO:0042248]; morphogenesis of follicular epithelium [GO:0016333]; Notch signaling pathway [GO:0007219]; oogenesis [GO:0048477]; optic lobe placode formation [GO:0001744]; ovarian follicle cell-cell adhesion [GO:0007299]; ovarian follicle cell development [GO:0030707]; protein glycosylation [GO:0006486] GO:0000139; GO:0001744; GO:0005576; GO:0005795; GO:0006486; GO:0006688; GO:0007219; GO:0007293; GO:0007298; GO:0007299; GO:0008375; GO:0016021; GO:0016333; GO:0030707; GO:0042248; GO:0046981; GO:0047915; GO:0048477 0 0 0 PF01762; Q5TYP4 CHOYP_CA112.1.1 m.15972 sp CA112_DANRE 27.273 935 624 18 4 915 2 903 9.55E-80 281 CA112_DANRE reviewed Uncharacterized protein C1orf112 homolog si:dkey-97o5.1 zgc:110228 Danio rerio (Zebrafish) (Brachydanio rerio) 911 0 0 0 0 0 PF14868; Q7SZ59 CHOYP_RASLC.1.1 m.1795 sp RASLC_DANRE 46.835 237 111 6 13 238 23 255 9.55E-66 207 RASLC_DANRE reviewed Ras-like protein family member 12 (RAS-like protein Ris) RASL12 zgc:63633 Danio rerio (Zebrafish) (Brachydanio rerio) 255 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0016020 0 0 0 PF00071; Q8NFF2 CHOYP_SLC24A4.1.1 m.27503 sp NCKX4_HUMAN 42.755 559 257 6 87 583 58 615 9.55E-142 427 NCKX4_HUMAN reviewed Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4) SLC24A4 NCKX4 Homo sapiens (Human) 622 amelogenesis [GO:0097186]; cellular calcium ion homeostasis [GO:0006874]; ion transport [GO:0006811]; response to stimulus [GO:0050896]; sensory perception of smell [GO:0007608] GO:0005262; GO:0005509; GO:0005737; GO:0005886; GO:0005887; GO:0006811; GO:0006874; GO:0007608; GO:0008273; GO:0015293; GO:0016020; GO:0030955; GO:0031402; GO:0050896; GO:0097186 0 0 0 PF01699; Q9CSP9 CHOYP_TTC14.1.1 m.54084 sp TTC14_MOUSE 38.208 424 247 6 1 409 1 424 9.55E-80 283 TTC14_MOUSE reviewed Tetratricopeptide repeat protein 14 (TPR repeat protein 14) Ttc14 Kiaa1980 Mus musculus (Mouse) 761 0 GO:0003676 0 0 0 PF13414; Q9NUV9 CHOYP_LOC100692036.2.2 m.64489 sp GIMA4_HUMAN 37.5 208 126 2 86 293 32 235 9.55E-42 151 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9VPW8 CHOYP_MONBRDRAFT_25725.1.1 m.62365 sp PINO_DROME 28.082 146 96 3 35 173 50 193 9.55E-15 73.6 PINO_DROME reviewed Protein pinocchio Pino smi21F CG4710 Drosophila melanogaster (Fruit fly) 249 olfactory behavior [GO:0042048]; regulation of response to DNA damage stimulus [GO:2001020]; sensory perception of smell [GO:0007608] GO:0007608; GO:0042048; GO:2001020 0 0 0 0 A5WUX7 CHOYP_LOC101364472.1.1 m.10788 sp CL065_DANRE 40.625 160 81 3 69 224 2 151 9.56E-30 112 CL065_DANRE reviewed "Probable peptide chain release factor C12orf65 homolog, mitochondrial" si:ch211-275j6.5 Danio rerio (Zebrafish) (Brachydanio rerio) 156 mitochondrial translational termination [GO:0070126]; rescue of stalled ribosome [GO:0072344] GO:0004045; GO:0005762; GO:0016150; GO:0043022; GO:0070126; GO:0072344 0 0 0 PF00472; O75808 CHOYP_LOC100741873.1.1 m.59886 sp CAN15_HUMAN 26.987 667 377 19 93 686 416 1045 9.56E-74 261 CAN15_HUMAN reviewed Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog) CAPN15 SOLH Homo sapiens (Human) 1086 0 GO:0003700; GO:0004198; GO:0005737; GO:0008233; GO:0008234; GO:0008270 0 0 0 PF00648;PF00641; P48058 CHOYP_GLUR8.1.1 m.41059 sp GRIA4_HUMAN 32.152 762 433 18 99 808 117 846 9.56E-120 387 GRIA4_HUMAN reviewed "Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4)" GRIA4 GLUR4 Homo sapiens (Human) 902 chemical synaptic transmission [GO:0007268]; glutamate receptor signaling pathway [GO:0007215]; response to fungicide [GO:0060992]; transport [GO:0006810] GO:0004970; GO:0004971; GO:0005231; GO:0005234; GO:0005886; GO:0006810; GO:0007215; GO:0007268; GO:0030054; GO:0030425; GO:0030666; GO:0032281; GO:0043025; GO:0043195; GO:0045211; GO:0060992; GO:1903561 0 0 0 PF01094;PF00060;PF10613; P81004 CHOYP_ERF1.1.1 m.37540 sp VDAC2_XENLA 63.929 280 99 2 3 280 3 282 9.56E-130 372 VDAC2_XENLA reviewed Voltage-dependent anion-selective channel protein 2 (VDAC-2) (Outer mitochondrial membrane protein porin) vdac2 Xenopus laevis (African clawed frog) 282 0 GO:0000166; GO:0005741; GO:0008308; GO:0015288; GO:0046930 0 0 0 PF01459; P81004 CHOYP_VDAC2.1.2 m.21871 sp VDAC2_XENLA 63.929 280 99 2 3 280 3 282 9.56E-130 372 VDAC2_XENLA reviewed Voltage-dependent anion-selective channel protein 2 (VDAC-2) (Outer mitochondrial membrane protein porin) vdac2 Xenopus laevis (African clawed frog) 282 0 GO:0000166; GO:0005741; GO:0008308; GO:0015288; GO:0046930 0 0 0 PF01459; P81004 CHOYP_VDAC2.2.2 m.56422 sp VDAC2_XENLA 63.929 280 99 2 3 280 3 282 9.56E-130 372 VDAC2_XENLA reviewed Voltage-dependent anion-selective channel protein 2 (VDAC-2) (Outer mitochondrial membrane protein porin) vdac2 Xenopus laevis (African clawed frog) 282 0 GO:0000166; GO:0005741; GO:0008308; GO:0015288; GO:0046930 0 0 0 PF01459; Q02858 CHOYP_DYAK_GE20925.1.1 m.50010 sp TIE2_MOUSE 47.727 44 23 0 85 128 289 332 9.56E-06 52 TIE2_MOUSE reviewed Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b) Tek Hyk Tie-2 Tie2 Mus musculus (Mouse) 1122 angiogenesis [GO:0001525]; cell-matrix adhesion [GO:0007160]; endothelial cell proliferation [GO:0001935]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; hemopoiesis [GO:0030097]; leukocyte migration [GO:0050900]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; patterning of blood vessels [GO:0001569]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cytokine secretion involved in immune response [GO:0002741]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; regulation of angiogenesis [GO:0045765]; regulation of cell migration [GO:0030334]; regulation of endothelial cell proliferation [GO:0001936]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of NIK/NF-kappaB signaling [GO:1901222]; response to retinoic acid [GO:0032526]; single organismal cell-cell adhesion [GO:0016337]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vasculogenesis [GO:0001570] GO:0001525; GO:0001569; GO:0001570; GO:0001934; GO:0001935; GO:0001936; GO:0002040; GO:0002741; GO:0004713; GO:0004714; GO:0004872; GO:0005524; GO:0005576; GO:0005856; GO:0005886; GO:0005887; GO:0005902; GO:0005911; GO:0005925; GO:0007160; GO:0007169; GO:0007507; GO:0009925; GO:0009986; GO:0010595; GO:0014068; GO:0016021; GO:0016323; GO:0016324; GO:0016337; GO:0016525; GO:0018108; GO:0030097; GO:0030334; GO:0030949; GO:0032526; GO:0032878; GO:0033138; GO:0034446; GO:0042307; GO:0043066; GO:0043552; GO:0045121; GO:0045765; GO:0045766; GO:0045785; GO:0046777; GO:0048014; GO:0048471; GO:0050900; GO:0051259; GO:0051894; GO:0051897; GO:0060347; GO:0070374; GO:1901222; GO:1902533; GO:2000251; GO:2000352 0 0 0 PF00041;PF10430;PF07714; Q0P466 CHOYP_TYW2.1.1 m.34773 sp TYW2_DANRE 35.433 127 67 3 28 147 6 124 9.56E-11 61.6 TYW2_DANRE reviewed tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase) trmt12 tyw2 zgc:153361 Danio rerio (Zebrafish) (Brachydanio rerio) 408 tRNA processing [GO:0008033] GO:0008033; GO:0016740 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 PF02475; Q63ZM9 CHOYP_LOC583668.1.1 m.19163 sp ZN830_XENLA 37.356 348 180 10 27 338 7 352 9.56E-53 180 ZN830_XENLA reviewed Zinc finger protein 830 (Coiled-coil domain-containing protein 16) znf830 ccdc16 Xenopus laevis (African clawed frog) 356 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; multicellular organism development [GO:0007275] GO:0005694; GO:0007067; GO:0007275; GO:0016607; GO:0046872; GO:0051301 0 0 0 0 Q8JZM4 CHOYP_LOC100366797.1.3 m.20765 sp DNER_MOUSE 43.243 74 27 2 842 915 471 529 9.56E-08 59.7 DNER_MOUSE reviewed Delta and Notch-like epidermal growth factor-related receptor (Brain EGF repeat-containing transmembrane protein) Dner Bet Bret Mus musculus (Mouse) 737 central nervous system development [GO:0007417]; glial cell differentiation [GO:0010001]; Notch receptor processing [GO:0007220]; Notch signaling pathway [GO:0007219]; skeletal muscle fiber development [GO:0048741] GO:0005112; GO:0005509; GO:0005769; GO:0005886; GO:0007219; GO:0007220; GO:0007417; GO:0010001; GO:0016021; GO:0030425; GO:0043025; GO:0048741 0 0 0 PF00008;PF12661; Q8VI56 CHOYP_LOC578599.5.8 m.39966 sp LRP4_MOUSE 39.306 173 96 5 1 170 1182 1348 9.56E-31 127 LRP4_MOUSE reviewed Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan) Lrp4 Kiaa0816 Mus musculus (Mouse) 1905 anatomical structure development [GO:0048856]; BMP signaling pathway [GO:0030509]; dendrite morphogenesis [GO:0048813]; dorsal/ventral pattern formation [GO:0009953]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; endocytosis [GO:0006897]; hair follicle development [GO:0001942]; kidney development [GO:0001822]; limb development [GO:0060173]; negative regulation of axonogenesis [GO:0050771]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ossification [GO:0030279]; negative regulation of Wnt signaling pathway [GO:0030178]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of presynaptic membrane organization [GO:1901631]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; postsynaptic membrane assembly [GO:0097104]; presynaptic membrane assembly [GO:0097105]; protein heterotetramerization [GO:0051290]; protein localization [GO:0008104]; proximal/distal pattern formation [GO:0009954]; receptor clustering [GO:0043113]; regulation of protein phosphorylation [GO:0001932]; skeletal muscle acetylcholine-gated channel clustering [GO:0071340]; synapse organization [GO:0050808]; synaptic growth at neuromuscular junction [GO:0051124]; Wnt signaling pathway [GO:0016055] GO:0001822; GO:0001932; GO:0001942; GO:0005509; GO:0005886; GO:0006897; GO:0008104; GO:0009953; GO:0009954; GO:0009986; GO:0014069; GO:0016021; GO:0016055; GO:0016600; GO:0030178; GO:0030279; GO:0030326; GO:0030425; GO:0030509; GO:0030971; GO:0031594; GO:0042475; GO:0042733; GO:0042803; GO:0043025; GO:0043113; GO:0048813; GO:0048856; GO:0050731; GO:0050771; GO:0050808; GO:0051124; GO:0051290; GO:0060173; GO:0071340; GO:0090090; GO:0097060; GO:0097104; GO:0097105; GO:0097110; GO:1901631; GO:1904395 0 0 0 PF12662;PF00057;PF00058; Q9CWP8 CHOYP_1433E.1.2 m.3639 sp DPOD4_MOUSE 38.235 102 61 2 30 130 7 107 9.56E-19 78.6 DPOD4_MOUSE reviewed DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) Pold4 Mus musculus (Mouse) 107 DNA-dependent DNA replication [GO:0006261]; DNA synthesis involved in DNA repair [GO:0000731]; positive regulation of endothelial cell proliferation [GO:0001938] GO:0000731; GO:0001938; GO:0003887; GO:0005634; GO:0006261; GO:0043625 0 0 0 PF04081; Q9JM99 CHOYP_contig_054454 m.64956 sp PRG4_MOUSE 35.669 157 101 0 305 461 447 603 9.56E-06 53.5 PRG4_MOUSE reviewed Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part] Prg4 Msf Szp Mus musculus (Mouse) 1054 hematopoietic stem cell proliferation [GO:0071425]; immune response [GO:0006955]; negative regulation of interleukin-6 biosynthetic process [GO:0045409]; regulation of cell proliferation [GO:0042127] GO:0005044; GO:0005615; GO:0006955; GO:0030247; GO:0042127; GO:0045409; GO:0071425 0 0 0 PF00045;PF01033; Q9Y493 CHOYP_contig_014341 m.16410 sp ZAN_HUMAN 34.497 487 282 10 562 1033 534 998 9.56E-20 99.8 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; O43414 CHOYP_ERI3.2.2 m.50300 sp ERI3_HUMAN 55.152 165 67 4 11 170 116 278 9.57E-55 179 ERI3_HUMAN reviewed ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein) ERI3 PINT1 PRNPIP PRNPIP1 Homo sapiens (Human) 337 "exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]" GO:0000467; GO:0004527; GO:0044822; GO:0046872 0 0 0 PF00929; P10079 CHOYP_TRIADDRAFT_26462.2.2 m.34482 sp FBP1_STRPU 52.117 307 145 1 161 467 176 480 9.57E-88 315 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11536 CHOYP_E74EA.2.2 m.62730 sp E74EB_DROME 82.857 105 18 0 224 328 779 883 9.57E-58 203 E74EB_DROME reviewed Ecdysone-induced protein 74EF isoform B (ETS-related protein E74B) Eip74EF E74 CG32180 Drosophila melanogaster (Fruit fly) 883 "autophagy [GO:0006914]; cell death [GO:0008219]; oogenesis [GO:0048477]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of development, heterochronic [GO:0040034]; salivary gland cell autophagic cell death [GO:0035071]" GO:0001077; GO:0003700; GO:0005634; GO:0006914; GO:0008219; GO:0035071; GO:0040034; GO:0043565; GO:0045944; GO:0048477 0 0 0 PF00178; Q23551 CHOYP_PHUM_PHUM226120.1.7 m.674 sp UNC22_CAEEL 39.837 123 72 2 8 129 4 125 9.57E-21 90.1 UNC22_CAEEL reviewed Twitchin (EC 2.7.11.1) (Uncoordinated protein 22) unc-22 ZK617.1 Caenorhabditis elegans 7158 negative regulation of cell division [GO:0051782]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107] GO:0004674; GO:0005524; GO:0018105; GO:0018107; GO:0031672; GO:0046872; GO:0051782 0 0 0 PF00041;PF07679;PF00069; Q6H236 CHOYP_CPIPJ_CPIJ000460.2.2 m.44835 sp PEG3_BOVIN 33.668 199 132 0 1 199 1361 1559 9.57E-12 67 PEG3_BOVIN reviewed Paternally-expressed gene 3 protein PEG3 Bos taurus (Bovine) 2387 "apoptotic process [GO:0006915]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0003676; GO:0005634; GO:0005737; GO:0006351; GO:0006915; GO:0046872 0 0 0 PF02023;PF00096;PF13912; Q6ZQQ6 CHOYP_LOC100892044.2.2 m.51486 sp WDR87_HUMAN 21.368 351 251 10 199 541 70 403 9.57E-12 74.7 WDR87_HUMAN reviewed WD repeat-containing protein 87 (Testis development protein NYD-SP11) WDR87 Homo sapiens (Human) 2873 0 GO:0005737 0 0 0 PF00400; Q8N475 CHOYP_LOC659040.2.2 m.34719 sp FSTL5_HUMAN 33.287 712 458 13 842 1544 140 843 9.57E-122 405 FSTL5_HUMAN reviewed Follistatin-related protein 5 (Follistatin-like protein 5) FSTL5 KIAA1263 Homo sapiens (Human) 847 0 GO:0005509; GO:0005576 0 0 0 PF07648; P02595 CHOYP_TNNC2.1.1 m.32533 sp CALM_PATSP 34.014 147 96 1 23 169 1 146 9.58E-20 84 CALM_PATSP reviewed Calmodulin (CaM) 0 Patinopecten sp. (Scallop) 149 0 GO:0005509 0 0 0 PF13499; P63057 CHOYP_NOE3.1.1 m.35682 sp NOE3_RAT 33.025 324 192 9 154 474 159 460 9.58E-46 169 NOE3_RAT reviewed Noelin-3 (Olfactomedin-3) (Optimedin) Olfm3 Noe3 Rattus norvegicus (Rat) 478 eye photoreceptor cell development [GO:0042462] GO:0005615; GO:0005794; GO:0030054; GO:0032281; GO:0042462; GO:0045202 0 0 0 PF12308;PF02191; Q06852 CHOYP_LOC100375776.1.3 m.8907 sp SLAP1_CLOTH 38.933 375 179 14 99 445 1430 1782 9.58E-27 122 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q24799 CHOYP_ISCW_ISCW021202.2.2 m.25479 sp MYPH_ECHGR 46.207 145 68 2 4 140 48 190 9.58E-36 124 MYPH_ECHGR reviewed Myophilin 0 Echinococcus granulosus (Hydatid tapeworm) 190 0 0 0 0 0 PF00402;PF00307; Q5PQ76 CHOYP_CA050.1.2 m.10226 sp CA050_XENLA 59.429 175 71 0 33 207 8 182 9.58E-76 229 CA050_XENLA reviewed Uncharacterized protein C1orf50 homolog 0 Xenopus laevis (African clawed frog) 184 0 0 0 0 0 PF10504; Q5VV43 CHOYP_BRAFLDRAFT_63436.1.1 m.53949 sp K0319_HUMAN 41.837 98 55 2 501 597 616 712 9.58E-12 72.4 K0319_HUMAN reviewed Dyslexia-associated protein KIAA0319 KIAA0319 Homo sapiens (Human) 1072 negative regulation of dendrite development [GO:2000171]; neuron migration [GO:0001764] GO:0001764; GO:0005769; GO:0005886; GO:0016021; GO:0031901; GO:2000171 0 0 0 PF02010; Q8CH62 CHOYP_CC44.1.1 m.66209 sp ORAV1_MOUSE 37.037 135 79 2 1 131 1 133 9.58E-23 89.7 ORAV1_MOUSE reviewed Oral cancer-overexpressed protein 1 homolog Oraov1 Mus musculus (Mouse) 137 double-strand break repair via homologous recombination [GO:0000724]; intra-S DNA damage checkpoint [GO:0031573]; meiotic DNA integrity checkpoint [GO:0044778]; mitotic DNA replication checkpoint [GO:0033314]; nucleotide-excision repair [GO:0006289] GO:0000724; GO:0006289; GO:0030896; GO:0031573; GO:0033314; GO:0035861; GO:0044778 0 0 0 PF09811; Q8JHV9 CHOYP_IAP1.1.4 m.25920 sp BIR7A_XENLA 40 110 64 1 13 120 292 401 9.58E-21 89 BIR7A_XENLA reviewed Baculoviral IAP repeat-containing protein 7-A (EC 6.3.2.-) (E3 ubiquitin-protein ligase EIAP-A) (Embryonic/Egg IAP) (xEIAP/XLX) (Inhibitor of apoptosis-like protein) (IAP-like protein) (XIAP homolog XLX) (XLX) birc7-a Xenopus laevis (African clawed frog) 401 multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; protein autoubiquitination [GO:0051865] GO:0005737; GO:0007275; GO:0008270; GO:0016874; GO:0043027; GO:0043066; GO:0043154; GO:0051865 0 0 0 PF00653; Q90YR8 CHOYP_RS6.8.12 m.36343 sp RS6_ICTPU 86.667 90 12 0 14 103 3 92 9.58E-54 171 RS6_ICTPU reviewed 40S ribosomal protein S6 rps6 Ictalurus punctatus (Channel catfish) (Silurus punctatus) 249 glucose homeostasis [GO:0042593]; translation [GO:0006412] GO:0003735; GO:0005634; GO:0006412; GO:0022627; GO:0042593; GO:0048471 0 0 0 PF01092; Q92609 CHOYP_TBCD5.1.1 m.66945 sp TBCD5_HUMAN 64.762 105 37 0 1 105 322 426 9.58E-42 156 TBCD5_HUMAN reviewed TBC1 domain family member 5 TBC1D5 KIAA0210 Homo sapiens (Human) 795 "activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of autophagy [GO:0010508]; positive regulation of receptor internalization [GO:0002092]; regulation of vesicle fusion [GO:0031338]; response to starvation [GO:0042594]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0002092; GO:0005096; GO:0005776; GO:0005829; GO:0006886; GO:0010008; GO:0010508; GO:0017137; GO:0030904; GO:0031338; GO:0031410; GO:0035612; GO:0042147; GO:0042594; GO:0090630; GO:0098779 0 0 0 PF00566; Q9W3W5 CHOYP_SHF.1.1 m.26419 sp WIF1_DROME 40.604 298 157 4 37 315 117 413 9.58E-71 233 WIF1_DROME reviewed Protein shifted (WIF-1-like protein) shf CG3135 Drosophila melanogaster (Fruit fly) 456 positive regulation of smoothened signaling pathway [GO:0045880]; protein stabilization [GO:0050821]; regulation of smoothened signaling pathway [GO:0008589]; smoothened signaling pathway [GO:0007224]; synaptic target recognition [GO:0008039] GO:0005576; GO:0005578; GO:0007224; GO:0008039; GO:0008589; GO:0045880; GO:0050821 0 0 0 PF02019; Q9Y493 CHOYP_PY04960.1.1 m.26352 sp ZAN_HUMAN 45.794 107 48 3 782 878 892 998 9.58E-06 53.5 ZAN_HUMAN reviewed Zonadhesin ZAN Homo sapiens (Human) 2812 binding of sperm to zona pellucida [GO:0007339]; single organismal cell-cell adhesion [GO:0016337] GO:0005886; GO:0007339; GO:0016021; GO:0016337 0 0 cd06263; PF08742;PF00629;PF01826;PF12714;PF00094; E1BD59 CHOYP_LOC100373137.3.3 m.60974 sp TRI56_BOVIN 21.799 289 185 10 20 281 20 294 9.59E-14 78.2 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; P00182 CHOYP_BRAFLDRAFT_61459.3.3 m.57050 sp CP2C3_RABIT 37.744 461 272 6 1 452 5 459 9.59E-99 308 CP2C3_RABIT reviewed Cytochrome P450 2C3 (EC 1.14.14.1) (CYPIIC3) (Cytochrome P450 PBc3) (Cytochrome P450 form 3B) CYP2C3 Oryctolagus cuniculus (Rabbit) 489 0 GO:0005506; GO:0005789; GO:0020037; GO:0031090; GO:0070330 0 0 0 PF00067; P48725 CHOYP_LOC100368547.38.40 m.59611 sp PCNT_MOUSE 44.203 138 75 1 33 170 2693 2828 9.59E-25 104 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; Q0P5B7 CHOYP_BRAFLDRAFT_209839.1.2 m.12805 sp AAAD_BOVIN 39.338 272 150 8 11 278 139 399 9.59E-45 158 AAAD_BOVIN reviewed Arylacetamide deacetylase (EC 3.1.1.3) AADAC Bos taurus (Bovine) 399 metabolic process [GO:0008152]; positive regulation of triglyceride catabolic process [GO:0010898] GO:0004806; GO:0005789; GO:0008152; GO:0010898; GO:0016021; GO:0017171; GO:0031090 0 0 0 PF07859; Q5SUV2 CHOYP_LOC752157.1.1 m.18775 sp MYBPP_MOUSE 32.41 361 218 8 55 405 12 356 9.59E-40 154 MYBPP_MOUSE reviewed MYCBP-associated protein (AMAM-1) (AMY-1-binding protein 1) (AMAP-1) Mycbpap Amap1 Mus musculus (Mouse) 932 cell differentiation [GO:0030154]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283] GO:0005737; GO:0007268; GO:0007275; GO:0007283; GO:0016020; GO:0030154 0 0 0 PF14646; Q5Y4N8 CHOYP_BRAFLDRAFT_88051.1.1 m.54941 sp AGRE1_RAT 35.799 338 141 16 188 474 42 354 9.59E-42 162 AGRE1_RAT reviewed Adhesion G protein-coupled receptor E2 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor) Adgre1 Emr1 Rattus norvegicus (Rat) 932 adaptive immune response [GO:0002250]; cell surface receptor signaling pathway [GO:0007166] GO:0002250; GO:0004930; GO:0005509; GO:0007166; GO:0009897; GO:0016021 0 0 0 PF00002;PF12662;PF07645;PF01825; Q8IX29 CHOYP_LOC100486001.1.1 m.6209 sp FBX16_HUMAN 42.481 266 131 5 11 258 20 281 9.59E-70 223 FBX16_HUMAN reviewed F-box only protein 16 FBXO16 FBX16 Homo sapiens (Human) 292 0 0 0 0 0 PF12937; Q92038 CHOYP_NASP.2.4 m.13405 sp ACOD_CYPCA 64.4 250 88 1 32 280 74 323 9.59E-113 331 ACOD_CYPCA reviewed Acyl-CoA desaturase (EC 1.14.19.1) (Delta(9)-desaturase) (Delta-9 desaturase) (Fatty acid desaturase) (Stearoyl-CoA desaturase) 0 Cyprinus carpio (Common carp) 327 unsaturated fatty acid biosynthetic process [GO:0006636] GO:0004768; GO:0005506; GO:0005789; GO:0006636; GO:0016021; GO:0016491 0 0 0 PF00487; O45782 CHOYP_LOC100176335.2.7 m.15527 sp ARD17_CAEEL 30.524 439 237 12 1 386 1 424 9.60E-59 200 ARD17_CAEEL reviewed Arrestin domain-containing protein 17 (Calcineurin-interacting protein 1) arrd-17 cnp-1 T12D8.4 Caenorhabditis elegans 426 behavior [GO:0007610] GO:0007610; GO:0030346 0 0 0 PF02752;PF00339; O57460 CHOYP_LOC100892120.1.1 m.28475 sp TLL1_DANRE 28.333 120 82 2 31 150 780 895 9.60E-07 52.8 TLL1_DANRE reviewed Dorsal-ventral patterning tolloid-like protein 1 (EC 3.4.24.-) (Mini fin protein) tll1 mfn tld tolloid Danio rerio (Zebrafish) (Brachydanio rerio) 1022 blood vessel development [GO:0001568]; determination of ventral identity [GO:0048264]; dorsal/ventral pattern formation [GO:0009953]; embryonic caudal fin morphogenesis [GO:0035124]; embryonic hemopoiesis [GO:0035162]; endothelial cell development [GO:0001885]; mesoderm formation [GO:0001707]; positive regulation of BMP signaling pathway [GO:0030513]; post-anal tail morphogenesis [GO:0036342]; proteolysis [GO:0006508] GO:0001568; GO:0001707; GO:0001885; GO:0004222; GO:0005509; GO:0005576; GO:0006508; GO:0008233; GO:0008237; GO:0008270; GO:0009953; GO:0030513; GO:0035124; GO:0035162; GO:0036342; GO:0048264 0 0 0 PF01400;PF00431; O70277 CHOYP_BRAFLDRAFT_69765.20.23 m.60870 sp TRIM3_RAT 27.358 106 73 2 35 136 625 730 9.60E-09 55.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O77245 CHOYP_E75.3.3 m.62187 sp E75_METEN 54.133 375 170 1 13 385 23 397 9.60E-135 424 E75_METEN reviewed Nuclear hormone receptor E75 (Nuclear receptor subfamily 1 group D member 3) E75 NR1D3 Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis) 606 "transcription, DNA-templated [GO:0006351]" GO:0003700; GO:0003707; GO:0005634; GO:0006351; GO:0008270; GO:0043565 0 0 0 PF00104;PF00105; P14248 CHOYP_contig_015098 m.17494 sp RPB1_PLAFD 26.165 279 154 16 146 408 2164 2406 9.60E-06 52.4 RPB1_PLAFD reviewed DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) RPII Plasmodium falciparum (isolate CDC / Honduras) 2452 transcription from RNA polymerase II promoter [GO:0006366] GO:0003677; GO:0003899; GO:0005665; GO:0006366; GO:0046872 0 0 0 PF04997;PF00623;PF04983;PF05000;PF04998;PF04992;PF04990;PF05001; Q13029 CHOYP_LOC100378993.1.1 m.13997 sp PRDM2_HUMAN 39.231 130 73 3 3 130 15 140 9.60E-20 100 PRDM2_HUMAN reviewed PR domain zinc finger protein 2 (EC 2.1.1.43) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ) PRDM2 KMT8 RIZ Homo sapiens (Human) 1718 "determination of adult lifespan [GO:0008340]; regulation of transcription, DNA-templated [GO:0006355]; response to estradiol [GO:0032355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0008340; GO:0018024; GO:0032355 0 0 0 PF00856;PF13912; Q460N5 CHOYP_PAR14.1.17 m.15859 sp PAR14_HUMAN 30.008 1333 827 34 17 1318 537 1794 9.60E-151 502 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q8IWZ3 CHOYP_LOC763941.3.4 m.36881 sp ANKH1_HUMAN 42.373 118 58 4 5 120 520 629 9.60E-16 75.5 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q9BX66 CHOYP_LOC100867381.7.8 m.50678 sp SRBS1_HUMAN 30.844 723 321 28 305 927 286 929 9.60E-57 219 SRBS1_HUMAN reviewed Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP) SORBS1 KIAA0894 KIAA1296 SH3D5 Homo sapiens (Human) 1292 cell-matrix adhesion [GO:0007160]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; glucose transport [GO:0015758]; insulin receptor signaling pathway [GO:0008286]; muscle contraction [GO:0006936]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of lipid biosynthetic process [GO:0046889]; stress fiber assembly [GO:0043149] GO:0001725; GO:0003779; GO:0005070; GO:0005158; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005886; GO:0005913; GO:0005915; GO:0005924; GO:0005925; GO:0006936; GO:0007160; GO:0008092; GO:0008286; GO:0015758; GO:0016363; GO:0032869; GO:0043149; GO:0045121; GO:0045725; GO:0046326; GO:0046889; GO:0048041; GO:0090004 0 0 0 PF00018;PF07653;PF14604;PF02208; Q9ESN6 CHOYP_LOC100374741.78.83 m.61660 sp TRIM2_MOUSE 23 200 146 5 259 452 547 744 9.60E-08 58.2 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9H091 CHOYP_LOC101297237.1.1 m.4466 sp ZMY15_HUMAN 25.077 323 171 7 3 259 364 681 9.60E-22 97.4 ZMY15_HUMAN reviewed Zinc finger MYND domain-containing protein 15 ZMYND15 Homo sapiens (Human) 742 "negative regulation of transcription, DNA-templated [GO:0045892]; spermatid development [GO:0007286]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0007286; GO:0045892; GO:0046872 0 0 0 PF01753; Q9P2E3 CHOYP_LOC100168619.1.1 m.40054 sp ZNFX1_HUMAN 28.082 292 195 8 264 555 247 523 9.60E-20 97.4 ZNFX1_HUMAN reviewed NFX1-type zinc finger-containing protein 1 ZNFX1 KIAA1404 Homo sapiens (Human) 1918 0 GO:0003700; GO:0005634; GO:0008270; GO:0044822 0 0 0 0 Q9UA35 CHOYP_S28A3.1.3 m.3387 sp S28A3_EPTST 42.788 624 317 10 2 619 19 608 9.60E-152 456 S28A3_EPTST reviewed Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (hfCNT) SLC28A3 CNT3 Eptatretus stoutii (Pacific hagfish) 683 0 GO:0005337; GO:0005887 0 0 0 PF07670;PF07662;PF01773; Q9UGM3 CHOYP_LOC560447.1.1 m.4754 sp DMBT1_HUMAN 46.087 115 56 3 256 366 1109 1221 9.60E-23 103 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A0JMH2 CHOYP_PHUM_PHUM127950.1.1 m.24843 sp CB069_DANRE 35.152 165 85 6 56 208 94 248 9.61E-21 91.3 CB069_DANRE reviewed UPF0565 protein C2orf69 homolog zgc:153521 Danio rerio (Zebrafish) (Brachydanio rerio) 341 0 GO:0005576 0 0 0 PF10561; A2AVA0 CHOYP_LOC100906063.3.3 m.63970 sp SVEP1_MOUSE 32.164 171 86 4 1 141 1096 1266 9.61E-15 75.9 SVEP1_MOUSE reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (Polydom)" Svep1 Mus musculus (Mouse) 3567 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; A9UMP7 CHOYP_LOC583138.1.1 m.8990 sp ENO4_XENLA 34.192 582 354 10 5 575 9 572 9.61E-107 336 ENO4_XENLA reviewed Enolase 4 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) eno4 Xenopus laevis (African clawed frog) 572 glycolytic process [GO:0006096] GO:0000015; GO:0000287; GO:0004634; GO:0006096 PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. {ECO:0000250|UniProtKB:Q8C042}. 0 0 PF00113;PF03952; P0C7B7 CHOYP_BRAFLDRAFT_120600.1.1 m.34174 sp ELIC_DICCH 24.688 320 202 11 6 303 14 316 9.61E-15 77.8 ELIC_DICCH reviewed Cys-loop ligand-gated ion channel (ELIC) 0 Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi) 321 0 GO:0005230; GO:0005886; GO:0016021 0 0 0 PF02931; P27113 CHOYP_BRAFLDRAFT_235822.1.1 m.41293 sp LYAM2_RABIT 25.355 422 252 14 52 452 167 546 9.61E-20 95.5 LYAM2_RABIT reviewed E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) SELE Oryctolagus cuniculus (Rabbit) 551 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246 0 0 0 PF00008;PF00059;PF00084; P62909 CHOYP_RS3.6.7 m.52376 sp RS3_RAT 91.324 219 18 1 5 223 18 235 9.61E-145 406 RS3_RAT reviewed 40S ribosomal protein S3 (EC 4.2.99.18) Rps3 Rattus norvegicus (Rat) 243 "apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to nerve growth factor stimulus [GO:1990090]; DNA repair [GO:0006281]; mitotic nuclear division [GO:0007067]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]" GO:0003684; GO:0003723; GO:0003735; GO:0005634; GO:0005730; GO:0005743; GO:0005819; GO:0006281; GO:0006351; GO:0006355; GO:0006412; GO:0006417; GO:0006915; GO:0006974; GO:0007067; GO:0008534; GO:0012505; GO:0019900; GO:0022627; GO:0030425; GO:0030529; GO:0042981; GO:0051301; GO:1990090 0 0 0 PF07650; Q28FE4 CHOYP_LOC586835.1.1 m.9969 sp MORN5_XENTR 73.988 173 45 0 1 173 1 173 9.61E-97 280 MORN5_XENTR reviewed MORN repeat-containing protein 5 morn5 TEgg084k12.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 178 0 0 0 0 0 PF02493; Q2KI92 CHOYP_AAEL_AAEL001424.1.1 m.40785 sp IMP2L_BOVIN 38.849 139 66 3 12 150 16 135 9.61E-23 91.3 IMP2L_BOVIN reviewed Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein) IMMP2L Bos taurus (Bovine) 177 blood circulation [GO:0008015]; brain development [GO:0007420]; cellular response to DNA damage stimulus [GO:0006974]; cerebellum vasculature development [GO:0061300]; mitochondrial respiratory chain complex assembly [GO:0033108]; ovarian follicle development [GO:0001541]; ovulation [GO:0030728]; protein processing involved in protein targeting to mitochondrion [GO:0006627]; respiratory electron transport chain [GO:0022904]; signal peptide processing [GO:0006465]; spermatogenesis [GO:0007283]; superoxide metabolic process [GO:0006801] GO:0001541; GO:0004252; GO:0006465; GO:0006627; GO:0006801; GO:0006974; GO:0007283; GO:0007420; GO:0008015; GO:0016021; GO:0022904; GO:0030728; GO:0033108; GO:0042720; GO:0061300 0 0 0 PF00717; Q4UMH6 CHOYP_ANR52.3.3 m.61991 sp Y381_RICFE 31.008 258 176 2 653 910 868 1123 9.61E-24 112 Y381_RICFE reviewed Putative ankyrin repeat protein RF_0381 RF_0381 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) 1179 guanosine tetraphosphate metabolic process [GO:0015969] GO:0015969 0 0 cd05399; PF00023;PF12796;PF04607; Q55EX9 CHOYP_TRIADDRAFT_64033.1.1 m.16118 sp Y8948_DICDI 30.04 253 161 7 39 284 19 262 9.61E-36 132 Y8948_DICDI reviewed Putative methyltransferase DDB_G0268948 (EC 2.1.1.-) DDB_G0268948 Dictyostelium discoideum (Slime mold) 263 methylation [GO:0032259] GO:0005737; GO:0008757; GO:0032259; GO:0045335 0 0 0 PF08241; Q5K651 CHOYP_LOC100176364.3.4 m.56017 sp SAMD9_HUMAN 31.122 196 104 8 729 899 679 868 9.61E-09 64.3 SAMD9_HUMAN reviewed Sterile alpha motif domain-containing protein 9 (SAM domain-containing protein 9) SAMD9 C7orf5 DRIF1 KIAA2004 OEF1 Homo sapiens (Human) 1589 0 GO:0005737; GO:0043231 0 0 0 PF07647; Q5R1U3 CHOYP_LOC101067698.2.2 m.27457 sp CYTA3_DICDI 43.333 90 45 2 44 133 11 94 9.61E-17 73.2 CYTA3_DICDI reviewed Cystatin-A3 (VSA745) cpiC DDB_G0277001 Dictyostelium discoideum (Slime mold) 94 hyperosmotic response [GO:0006972]; proteolysis [GO:0006508] GO:0004869; GO:0005737; GO:0006508; GO:0006972 0 0 0 PF00031; Q5RCU5 CHOYP_LOC100366455.3.3 m.28840 sp CBR1_PONAB 56.827 271 116 1 5 274 7 277 9.61E-112 326 CBR1_PONAB reviewed Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) CBR1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 277 drug metabolic process [GO:0017144]; vitamin K metabolic process [GO:0042373] GO:0004090; GO:0005737; GO:0017144; GO:0042373; GO:0047021; GO:0050221 0 0 0 PF00106; Q7M456 CHOYP_RNOY.1.3 m.4495 sp RNOY_CRAGI 48.684 228 94 5 19 243 2 209 9.61E-75 229 RNOY_CRAGI reviewed Ribonuclease Oy (RNase Oy) (EC 3.1.27.-) 0 Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 213 0 GO:0003723; GO:0005576; GO:0033897 0 0 cd01061; PF00445; Q8IWB1 CHOYP_ITPRIP.1.1 m.720 sp IPRI_HUMAN 32.54 126 74 5 494 618 366 481 9.61E-07 55.8 IPRI_HUMAN reviewed "Inositol 1,4,5-trisphosphate receptor-interacting protein (Protein DANGER)" ITPRIP DANGER KIAA1754 Homo sapiens (Human) 547 0 GO:0005886; GO:0016020 0 0 0 PF03281; Q8N0X4 CHOYP_LOC100700757.1.1 m.23394 sp CLYBL_HUMAN 55.229 306 136 1 29 334 33 337 9.61E-117 343 CLYBL_HUMAN reviewed "Citrate lyase subunit beta-like protein, mitochondrial (Citrate lyase beta-like) (Beta-methylmalate synthase) (EC 2.3.3.-) (Malate synthase) (EC 2.3.3.9)" CLYBL CLB Homo sapiens (Human) 340 0 GO:0000287; GO:0004474; GO:0005739 0 0 0 PF03328; Q96L03 CHOYP_LOC576665.1.2 m.10868 sp SPT17_HUMAN 40.705 312 170 7 1 300 52 360 9.61E-72 228 SPT17_HUMAN reviewed Spermatogenesis-associated protein 17 SPATA17 Homo sapiens (Human) 361 0 GO:0005737 0 0 0 PF00612; Q99996 CHOYP_AKAP9.4.9 m.16438 sp AKAP9_HUMAN 40.351 114 56 5 1 107 3577 3685 9.61E-10 58.9 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9EQZ7 CHOYP_RIMS2.1.3 m.35153 sp RIMS2_MOUSE 31.492 362 223 9 166 516 603 950 9.61E-31 133 RIMS2_MOUSE reviewed Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 2) Rims2 Rab3ip2 Rim2 Mus musculus (Mouse) 1530 calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cAMP-mediated signaling [GO:0019933]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; neurotransmitter secretion [GO:0007269]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; spontaneous neurotransmitter secretion [GO:0061669] GO:0005622; GO:0006886; GO:0007269; GO:0010628; GO:0017156; GO:0017157; GO:0019933; GO:0030054; GO:0030073; GO:0042391; GO:0043005; GO:0044325; GO:0046872; GO:0048786; GO:0048791; GO:0061669; GO:0070062; GO:0097151; GO:1903861; GO:2000463 0 0 0 PF00168;PF02318; Q9U298 CHOYP_LOC100372668.1.2 m.40566 sp ACH8_CAEEL 28.076 317 214 5 23 326 19 334 9.61E-36 139 ACH8_CAEEL reviewed Neuronal acetylcholine receptor subunit eat-2 (Abnormal pharyngeal pumping eat-2) eat-2 Y48B6A.4 Caenorhabditis elegans 474 "action potential [GO:0001508]; determination of adult lifespan [GO:0008340]; larval feeding behavior [GO:0030536]; multicellular organismal reproductive process [GO:0048609]; negative regulation of gene expression [GO:0010629]; neuromuscular synaptic transmission [GO:0007274]; pharyngeal pumping [GO:0043050]; positive regulation of eating behavior [GO:1904000]; positive regulation of gene expression [GO:0010628]; positive regulation of nematode larval development [GO:0061063]; regulation of brood size [GO:0060378]; regulation of multicellular organism growth [GO:0040014]; regulation of pharyngeal pumping [GO:0043051]; signal transduction [GO:0007165]; synaptic transmission, cholinergic [GO:0007271]" GO:0001508; GO:0004889; GO:0005892; GO:0007165; GO:0007271; GO:0007274; GO:0008340; GO:0010628; GO:0010629; GO:0030054; GO:0030536; GO:0031594; GO:0040014; GO:0042166; GO:0043050; GO:0043051; GO:0045203; GO:0045211; GO:0048609; GO:0060378; GO:0061063; GO:1904000 0 0 0 PF02931;PF02932; O62640 CHOYP_LOC100741028.3.4 m.44464 sp PIAP_PIG 36.332 289 161 9 344 625 86 358 9.62E-52 185 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P82198 CHOYP_BRAFLDRAFT_76825.1.1 m.2818 sp BGH3_MOUSE 27.491 291 183 11 39 318 98 371 9.62E-21 96.3 BGH3_MOUSE reviewed Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3) Tgfbi Mus musculus (Mouse) 683 angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; cell proliferation [GO:0008283]; chondrocyte differentiation [GO:0002062]; extracellular matrix organization [GO:0030198] GO:0001525; GO:0002062; GO:0005518; GO:0005578; GO:0005604; GO:0005615; GO:0005802; GO:0007155; GO:0008283; GO:0030198; GO:0050839; GO:0050840; GO:0070062 0 0 0 PF02469; Q502M6 CHOYP_LOC100635111.12.13 m.64621 sp ANR29_DANRE 39.157 166 101 0 96 261 35 200 9.62E-33 124 ANR29_DANRE reviewed Ankyrin repeat domain-containing protein 29 ankrd29 si:dkey-121a11.5 zgc:111996 Danio rerio (Zebrafish) (Brachydanio rerio) 298 0 0 0 0 0 PF00023;PF12796; Q5R896 CHOYP_DVIR_GJ19769.1.1 m.46852 sp EVL_PONAB 38.785 428 213 13 299 696 9 417 9.62E-51 185 EVL_PONAB reviewed Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) EVL Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 422 actin polymerization or depolymerization [GO:0008154]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of stress fiber assembly [GO:0051496]; protein homotetramerization [GO:0051289] GO:0005737; GO:0005856; GO:0005925; GO:0008154; GO:0010633; GO:0016020; GO:0030027; GO:0030838; GO:0051289; GO:0051496; GO:1900028 0 0 0 PF08776;PF00568; Q5ZIJ9 CHOYP_MIB1.1.4 m.15697 sp MIB2_CHICK 29.565 575 349 7 3 550 324 869 9.62E-76 261 MIB2_CHICK reviewed E3 ubiquitin-protein ligase MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) MIB2 RCJMB04_25j24 Gallus gallus (Chicken) 954 Notch signaling pathway [GO:0007219] GO:0004842; GO:0005737; GO:0007219; GO:0008270; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12796;PF06701;PF00569; Q6AY20 CHOYP_M6PR.1.1 m.51635 sp MPRD_RAT 42.975 242 123 6 77 315 49 278 9.62E-59 192 MPRD_RAT reviewed Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) M6pr Rattus norvegicus (Rat) 278 0 GO:0005537; GO:0005765; GO:0005802; GO:0015578; GO:0016021 0 0 0 PF02157; Q9WVL6 CHOYP_EXTL3.1.1 m.40755 sp EXTL3_MOUSE 79.422 277 57 0 1 277 632 908 9.62E-159 469 EXTL3_MOUSE reviewed Exostosin-like 3 (EC 2.4.1.223) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostosis-like protein 3) Extl3 Mus musculus (Mouse) 918 glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012] GO:0001888; GO:0005783; GO:0005789; GO:0006024; GO:0015012; GO:0016021; GO:0046872 PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. 0 0 PF03016;PF09258; Q9Z252 CHOYP_LOC100329062.2.2 m.39236 sp LIN7B_RAT 78.01 191 42 0 3 193 6 196 9.62E-108 310 LIN7B_RAT reviewed Protein lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) Lin7b Mals2 Veli1a Veli2 Rattus norvegicus (Rat) 207 cell-cell junction assembly [GO:0007043]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031] GO:0005911; GO:0005923; GO:0006887; GO:0007043; GO:0007269; GO:0014069; GO:0015031; GO:0016323; GO:0030165; GO:0043005; GO:0045199; GO:0045202; GO:0045211; GO:0098793; GO:1903361 0 0 0 PF02828;PF00595; A4IHD2 CHOYP_ARIP4.2.3 m.15675 sp ARIP4_XENTR 54.407 329 135 4 1 315 419 746 9.63E-118 374 ARIP4_XENTR reviewed Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) rad54l2 arip4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1396 0 GO:0003677; GO:0004386; GO:0005524; GO:0005634 0 0 0 PF00271;PF00176; O01761 CHOYP_ISCW_ISCW023694.1.2 m.31647 sp UNC89_CAEEL 24.841 471 286 20 180 616 4462 4898 9.63E-08 61.2 UNC89_CAEEL reviewed Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) unc-89 C09D1.1 Caenorhabditis elegans 8081 myosin filament assembly [GO:0031034]; regulation of Rho protein signal transduction [GO:0035023]; skeletal muscle myosin thick filament assembly [GO:0030241] GO:0004672; GO:0005089; GO:0005524; GO:0017048; GO:0019902; GO:0030241; GO:0031034; GO:0031430; GO:0031672; GO:0035023 0 0 0 PF00041;PF07679;PF00069;PF05177;PF00621; P0CT40 CHOYP_LOC100497321.2.4 m.49241 sp TF29_SCHPO 23.203 487 308 19 386 859 398 831 9.63E-10 66.6 TF29_SCHPO reviewed Transposon Tf2-9 polyprotein (Retrotransposable element Tf2 155 kDa protein) Tf2-9 SPBC9B6.02c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1333 DNA integration [GO:0015074]; DNA recombination [GO:0006310] GO:0003677; GO:0003723; GO:0003887; GO:0003964; GO:0004190; GO:0004519; GO:0005737; GO:0006310; GO:0015074; GO:0046872 0 0 0 PF12382;PF00665;PF00078; P38287 CHOYP_KLTH0E11946G.1.1 m.16186 sp CSH1_YEAST 35.714 196 105 4 75 263 62 243 9.63E-30 119 CSH1_YEAST reviewed Mannosyl phosphorylinositol ceramide synthase CSH1 (EC 2.-.-.-) (CSG1/SUR1 homolog 1) CSH1 YBR161W YBR1212 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 376 glycosphingolipid biosynthetic process [GO:0006688]; mannosyl-inositol phosphorylceramide biosynthetic process [GO:0051999]; sphingolipid biosynthetic process [GO:0030148] GO:0000030; GO:0000139; GO:0005774; GO:0006688; GO:0016021; GO:0016757; GO:0030148; GO:0051999 0 0 0 PF04488; P70227 CHOYP_LOC100375107.4.4 m.33765 sp ITPR3_MOUSE 22.965 1511 892 46 1 1323 4 1430 9.63E-68 259 ITPR3_MOUSE reviewed "Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)" Itpr3 Mus musculus (Mouse) 2670 calcium ion transport [GO:0006816]; calcium ion transport into cytosol [GO:0060402]; cellular response to cAMP [GO:0071320]; G-protein coupled receptor signaling pathway [GO:0007186]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]; response to calcium ion [GO:0051592]; sensory perception of bitter taste [GO:0050913]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917] GO:0000822; GO:0005220; GO:0005509; GO:0005634; GO:0005640; GO:0005654; GO:0005730; GO:0005737; GO:0005789; GO:0005829; GO:0005886; GO:0005887; GO:0006816; GO:0007186; GO:0007613; GO:0015278; GO:0016020; GO:0030425; GO:0035091; GO:0043025; GO:0043209; GO:0043235; GO:0043533; GO:0048471; GO:0050913; GO:0050916; GO:0050917; GO:0051260; GO:0051291; GO:0051592; GO:0060291; GO:0060402; GO:0070679; GO:0071320 0 0 0 PF08709;PF00520;PF02815;PF08454;PF01365; Q29043 CHOYP_LOC100009874.1.1 m.4894 sp FUT1_PIG 28.92 287 172 10 47 318 83 352 9.63E-33 127 FUT1_PIG reviewed "Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1)" FUT1 Sus scrofa (Pig) 365 fucosylation [GO:0036065]; protein glycosylation [GO:0006486] GO:0006486; GO:0008107; GO:0016021; GO:0032580; GO:0036065 PATHWAY: Protein modification; protein glycosylation. 0 0 PF01531; Q2KI83 CHOYP_LOC100635352.1.1 m.9481 sp DJC17_BOVIN 46.44 323 137 6 9 322 6 301 9.63E-86 263 DJC17_BOVIN reviewed DnaJ homolog subfamily C member 17 DNAJC17 Bos taurus (Bovine) 304 "negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; toxin transport [GO:1901998]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000166; GO:0003723; GO:0005634; GO:0005737; GO:0006351; GO:1901998 0 0 cd06257; PF00226;PF00076; Q6PFY8 CHOYP_LOC100369929.2.5 m.34194 sp TRI45_MOUSE 25 220 133 9 13 215 135 339 9.63E-07 55.5 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; P86854 CHOYP_CD209.2.6 m.3514 sp PLCL_MYTGA 28.148 135 94 3 237 371 25 156 9.64E-16 77.4 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; P97868 CHOYP_RBBP6.1.1 m.24681 sp RBBP6_MOUSE 38.406 552 281 12 1 539 1 506 9.64E-105 373 RBBP6_MOUSE reviewed E3 ubiquitin-protein ligase RBBP6 (EC 6.3.2.-) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis) Rbbp6 P2pr Pact Mus musculus (Mouse) 1790 cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053] GO:0001701; GO:0004842; GO:0005654; GO:0005694; GO:0005730; GO:0005737; GO:0005815; GO:0006260; GO:0006275; GO:0006397; GO:0006974; GO:0008270; GO:0016874; GO:0035264; GO:0042787; GO:0044822; GO:0048568; GO:0061053; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF08783;PF04564;PF13696; Q06210 CHOYP_GFPT1.1.2 m.33256 sp GFPT1_HUMAN 60.076 263 90 2 1 260 1 251 9.64E-104 319 GFPT1_HUMAN reviewed Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1) GFPT1 GFAT GFPT Homo sapiens (Human) 699 carbohydrate metabolic process [GO:0005975]; cellular response to insulin stimulus [GO:0032869]; circadian regulation of gene expression [GO:0032922]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glucosamine biosynthetic process [GO:0006042]; glutamine metabolic process [GO:0006541]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of glycogen biosynthetic process [GO:0045719]; protein homotetramerization [GO:0051289]; response to sucrose [GO:0009744]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]; UDP-N-acetylglucosamine metabolic process [GO:0006047] GO:0004360; GO:0005829; GO:0005975; GO:0006002; GO:0006042; GO:0006047; GO:0006048; GO:0006112; GO:0006541; GO:0009744; GO:0016597; GO:0030246; GO:0032869; GO:0032922; GO:0036498; GO:0045719; GO:0051289; GO:0070062 PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000250|UniProtKB:P82808}. 0 0 PF01380; Q0VAA2 CHOYP_LOC101391827.1.1 m.21990 sp LR74A_HUMAN 34.921 126 81 1 50 174 85 210 9.64E-19 85.9 LR74A_HUMAN reviewed Leucine-rich repeat-containing protein 74A (Leucine-rich repeat-containing protein 74) LRRC74A C14orf166B LRRC74 Homo sapiens (Human) 488 0 0 0 0 0 PF13516; Q25145 CHOYP_TPM.10.19 m.23034 sp TPM_HALRU 70.745 188 55 0 1 188 1 188 9.64E-79 239 TPM_HALRU reviewed Tropomyosin 0 Haliotis rufescens (California red abalone) 284 0 0 0 0 0 PF00261; Q5ZIK9 CHOYP_COPE.1.1 m.48265 sp COPE_CHICK 68.836 292 91 0 17 308 17 308 9.64E-157 443 COPE_CHICK reviewed Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) COPE RCJMB04_25f12 Gallus gallus (Chicken) 308 "ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]" GO:0000139; GO:0005198; GO:0005654; GO:0006888; GO:0006890; GO:0006891; GO:0015031; GO:0030126 0 0 0 0 Q8BRH4 CHOYP_MLL3.1.3 m.16294 sp KMT2C_MOUSE 28.722 571 308 20 55 562 1161 1695 9.64E-38 160 KMT2C_MOUSE reviewed Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.43) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog) Kmt2c Mll3 Mus musculus (Mouse) 4903 "eyelid development in camera-type eye [GO:0061029]; histone methylation [GO:0016571]; multicellular organism growth [GO:0035264]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of gene expression [GO:0010468]; regulation of transcription, DNA-templated [GO:0006355]; single fertilization [GO:0007338]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0007338; GO:0008270; GO:0010468; GO:0016571; GO:0016746; GO:0035097; GO:0035264; GO:0042800; GO:0044666; GO:0044822; GO:0048146; GO:0061029 0 0 0 PF05965;PF05964;PF00628;PF00856; Q96RW7 CHOYP_HMCN1.41.44 m.63261 sp HMCN1_HUMAN 27.869 488 317 19 108 581 4051 4517 9.64E-25 116 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9EPF3 CHOYP_CG14207.1.1 m.41523 sp CRYAB_SPAJD 34.711 121 67 3 78 197 54 163 9.64E-14 69.3 CRYAB_SPAJD reviewed Alpha-crystallin B chain (Alpha(B)-crystallin) CRYAB Spalax judaei (Judean Mountains blind mole rat) (Nannospalax judaei) 175 0 GO:0005212; GO:0005634; GO:0005737; GO:0042803; GO:0046872 0 0 0 PF00525;PF00011; Q9VCA8 CHOYP_LOC589750.1.5 m.3190 sp ANKHM_DROME 31.061 528 291 21 411 910 552 1034 9.64E-43 174 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; E1BD59 CHOYP_ZF_BBOX_RING_-1.4.10 m.32022 sp TRI56_BOVIN 27.881 269 175 7 11 268 17 277 9.65E-24 109 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O14867 CHOYP_LOC100575377.10.10 m.62180 sp BACH1_HUMAN 28.205 117 84 0 7 123 11 127 9.65E-10 65.5 BACH1_HUMAN reviewed Transcription regulator protein BACH1 (BTB and CNC homolog 1) (HA2303) BACH1 Homo sapiens (Human) 736 "DNA repair [GO:0006281]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of transcription involved in G2/M transition of mitotic cell cycle [GO:0000117]" GO:0000083; GO:0000117; GO:0000122; GO:0000980; GO:0001078; GO:0001205; GO:0001206; GO:0003700; GO:0005634; GO:0005737; GO:0006281; GO:0006355; GO:0016567; GO:0020037; GO:0031463; GO:0061418 0 0 0 PF00651;PF03131; O35920 CHOYP_CAN8.2.2 m.35732 sp CAN9_RAT 37.475 499 290 10 35 527 5 487 9.65E-108 340 CAN9_RAT reviewed Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (New calpain 4) (nCL-4) Capn9 Ncl4 Rattus norvegicus (Rat) 690 digestion [GO:0007586] GO:0004198; GO:0005509; GO:0005737; GO:0007586 0 0 0 PF01067;PF13833;PF00648; O62640 CHOYP_BIR7A.1.2 m.8728 sp PIAP_PIG 31.233 365 172 10 20 319 7 357 9.65E-52 177 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; O62640 CHOYP_TIAP2.4.13 m.34724 sp PIAP_PIG 32.852 277 161 5 1187 1448 91 357 9.65E-46 172 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P17978 CHOYP_BRAFLDRAFT_71752.4.4 m.60904 sp VGB_STAAU 27.854 219 125 10 261 464 89 289 9.65E-08 57 VGB_STAAU reviewed Virginiamycin B lyase (EC 4.2.99.-) (Streptogramin B lyase) vgb vgh Staphylococcus aureus 299 antibiotic catabolic process [GO:0017001]; response to antibiotic [GO:0046677] GO:0000287; GO:0016835; GO:0017001; GO:0046677 0 0 0 0 Q17938 CHOYP_MGC154819.1.1 m.24654 sp DAF36_CAEEL 40.338 414 227 10 55 458 9 412 9.65E-107 326 DAF36_CAEEL reviewed Cholesterol 7-desaturase (EC 1.14.19.21) (Cholesterol desaturase daf-36) daf-36 C12D8.5 Caenorhabditis elegans 428 cholesterol metabolic process [GO:0008203] GO:0005737; GO:0008203; GO:0016021; GO:0016491; GO:0046872; GO:0051537 "PATHWAY: Steroid hormone biosynthesis; dafachronic acid biosynthesis. {ECO:0000269|PubMed:21632547, ECO:0000269|PubMed:21749634}." 0 0 PF00355; Q95SX7 CHOYP_LOC100889850.2.2 m.60463 sp RTBS_DROME 25.749 167 111 4 3 161 705 866 9.65E-07 54.3 RTBS_DROME reviewed Probable RNA-directed DNA polymerase from transposon BS (EC 2.7.7.49) (Reverse transcriptase) RTase Drosophila melanogaster (Fruit fly) 906 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q9NQA5 CHOYP_TRPV1.1.1 m.31852 sp TRPV5_HUMAN 28.086 324 163 15 86 396 79 345 9.65E-14 77.4 TRPV5_HUMAN reviewed Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3) TRPV5 ECAC1 Homo sapiens (Human) 729 calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; protein tetramerization [GO:0051262] GO:0005262; GO:0005886; GO:0005887; GO:0006816; GO:0016324; GO:0051262; GO:0070588 0 0 0 PF00023;PF12796;PF00520; Q9UQB8 CHOYP_BI2L2.1.1 m.50313 sp BAIP2_HUMAN 34.815 135 76 5 55 177 359 493 9.65E-13 70.1 BAIP2_HUMAN reviewed Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) BAIAP2 Homo sapiens (Human) 552 actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; axonogenesis [GO:0007409]; dendrite development [GO:0016358]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; insulin receptor signaling pathway [GO:0008286]; plasma membrane organization [GO:0007009]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of dendritic spine morphogenesis [GO:0061003]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of synaptic plasticity [GO:0048167]; response to bacterium [GO:0009617]; vascular endothelial growth factor receptor signaling pathway [GO:0048010] GO:0001726; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005913; GO:0007009; GO:0007409; GO:0008022; GO:0008093; GO:0008286; GO:0008360; GO:0009617; GO:0014069; GO:0016358; GO:0030141; GO:0030175; GO:0030838; GO:0032956; GO:0038096; GO:0042802; GO:0043025; GO:0043197; GO:0048010; GO:0048167; GO:0051017; GO:0051764; GO:0061003; GO:0070062; GO:0070064; GO:0098641; GO:2000251 0 0 0 PF08397;PF14604; Q9VXT2 CHOYP_LOC755300.1.1 m.8324 sp DJC25_DROME 50.467 321 151 2 20 339 18 331 9.65E-96 290 DJC25_DROME reviewed DnaJ homolog subfamily C member 25 homolog CG7872 Drosophila melanogaster (Fruit fly) 333 0 GO:0012505; GO:0016021 0 0 cd06257; PF00226; D4AR77 CHOYP_NEMVEDRAFT_V1G197267.1.1 m.9960 sp A6907_ARTBC 23.52 625 384 28 21 616 363 922 9.66E-23 107 A6907_ARTBC reviewed Uncharacterized secreted protein ARB_06907 ARB_06907 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) 930 0 GO:0005576; GO:0008236 0 0 0 PF00326; O45870 CHOYP_LOC100878974.1.1 m.57326 sp NSMA_CAEEL 35.539 408 235 8 17 407 38 434 9.66E-84 265 NSMA_CAEEL reviewed Putative neutral sphingomyelinase (EC 3.1.4.12) T27F6.6 Caenorhabditis elegans 434 sphingolipid metabolic process [GO:0006665] GO:0004767; GO:0006665; GO:0016021; GO:0046872 PATHWAY: Lipid metabolism; sphingolipid metabolism. 0 0 PF03372; Q5RA42 CHOYP_LOC100533384.5.5 m.59083 sp IF1AX_PONAB 88.136 118 14 0 1 118 1 118 9.66E-72 213 IF1AX_PONAB reviewed "Eukaryotic translation initiation factor 1A, X-chromosomal (eIF-1A X isoform) (Eukaryotic translation initiation factor 4C) (eIF-4C)" EIF1AX Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 144 0 GO:0003743; GO:0044822 0 0 0 PF01176; Q6PBN5 CHOYP_LOC581694.1.1 m.56513 sp AUP1_DANRE 35.407 418 250 11 1 404 6 417 9.66E-73 236 AUP1_DANRE reviewed Ancient ubiquitous protein 1 aup1 Danio rerio (Zebrafish) (Brachydanio rerio) 423 ER-associated ubiquitin-dependent protein catabolic process [GO:0030433] GO:0000839; GO:0030176; GO:0030433; GO:0043130; GO:0097027 0 0 0 PF02845; Q6UX01 CHOYP_LOC100376583.1.1 m.51051 sp LMBRL_HUMAN 52.049 488 218 5 2 488 3 475 9.66E-164 475 LMBRL_HUMAN reviewed Protein LMBR1L (Limb region 1 protein homolog-like) (Lipocalin-1-interacting membrane receptor) (Lipocalin-interacting membrane receptor) LMBR1L KIAA1174 LIMR UNQ458/PRO783 Homo sapiens (Human) 489 endocytosis [GO:0006897] GO:0005886; GO:0006897; GO:0016021 0 0 0 PF04791; Q6ZPS2 CHOYP_WHSC1.1.1 m.15310 sp CRNS1_MOUSE 51.481 270 128 2 14 282 500 767 9.66E-89 286 CRNS1_MOUSE reviewed Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1) Carns1 Atpgd1 Kiaa1394 Mus musculus (Mouse) 827 carnosine biosynthetic process [GO:0035499] GO:0005524; GO:0016887; GO:0035499; GO:0046872; GO:0047730 0 0 0 0 Q86WC6 CHOYP_PPR27.1.1 m.10278 sp PPR27_HUMAN 38.776 147 82 2 1 141 1 145 9.66E-31 112 PPR27_HUMAN reviewed Protein phosphatase 1 regulatory subunit 27 (Dysferlin-interacting protein 1) (Toonin) PPP1R27 DYSFIP1 Homo sapiens (Human) 154 negative regulation of phosphatase activity [GO:0010923] GO:0004864; GO:0010923; GO:0019902 0 0 0 0 Q8AWF2 CHOYP_NACA.5.9 m.41112 sp NACA_ORENI 82.759 116 16 1 1 112 29 144 9.66E-54 171 NACA_ORENI reviewed Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) naca Oreochromis niloticus (Nile tilapia) (Tilapia nilotica) 215 protein transport [GO:0015031] GO:0015031 0 0 0 PF01849; Q93356 CHOYP_EMX1.1.2 m.6187 sp HM37_CAEEL 33.333 75 50 0 86 160 43 117 9.66E-09 59.7 HM37_CAEEL reviewed Homeobox protein ceh-37 ceh-37 C37E2.5 Caenorhabditis elegans 278 "mRNA transcription [GO:0009299]; neuron fate specification [GO:0048665]; olfactory behavior [GO:0042048]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere organization [GO:0032200]" GO:0000723; GO:0000781; GO:0000784; GO:0003691; GO:0006355; GO:0006357; GO:0008301; GO:0009299; GO:0016233; GO:0032200; GO:0042048; GO:0042162; GO:0048665 0 0 0 PF00046; Q9P031 CHOYP_TAP26.1.1 m.16439 sp TAP26_HUMAN 31.959 194 79 4 34 174 45 238 9.66E-17 78.2 TAP26_HUMAN reviewed Thyroid transcription factor 1-associated protein 26 (TTF-1-associated protein 26) (Coiled-coil domain-containing protein 59) (TTF-1-associated protein BR2) CCDC59 BR22 TAP26 HSPC128 Homo sapiens (Human) 241 "cellular protein metabolic process [GO:0044267]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0000462; GO:0005634; GO:0005654; GO:0006351; GO:0006355; GO:0044267; GO:0044822 0 0 0 PF08524; Q9VYB7 CHOYP_BRAFLDRAFT_89531.1.1 m.17910 sp TPST_DROME 56.403 367 145 2 7 360 1 365 9.66E-150 435 TPST_DROME reviewed Protein-tyrosine sulfotransferase (EC 2.8.2.20) (Transport and Golgi organization protein 13) (Tango-13) (Tyrosylprotein sulfotransferase) (TPST) Tango13 CG32632 Drosophila melanogaster (Fruit fly) 499 peptidyl-tyrosine sulfation [GO:0006478]; protein secretion [GO:0009306] GO:0000139; GO:0005794; GO:0006478; GO:0008476; GO:0009306; GO:0016021 0 0 0 0 O15394 CHOYP_LOC100618341.1.1 m.42477 sp NCAM2_HUMAN 23.285 481 312 21 126 588 209 650 9.67E-13 75.5 NCAM2_HUMAN reviewed Neural cell adhesion molecule 2 (N-CAM-2) (NCAM-2) NCAM2 NCAM21 Homo sapiens (Human) 837 neuron cell-cell adhesion [GO:0007158] GO:0005886; GO:0007158; GO:0016021; GO:0030424 0 0 0 PF00041;PF07679; O15455 CHOYP_LOC101171393.1.1 m.29174 sp TLR3_HUMAN 22.909 275 171 8 97 341 460 723 9.67E-06 51.6 TLR3_HUMAN reviewed Toll-like receptor 3 (CD antigen CD283) TLR3 Homo sapiens (Human) 904 activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic signaling pathway [GO:0097190]; cellular response to drug [GO:0035690]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to interferon-gamma [GO:0071346]; cellular response to mechanical stimulus [GO:0071260]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; I-kappaB phosphorylation [GO:0007252]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; microglial cell activation involved in immune response [GO:0002282]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha biosynthetic process [GO:0045356]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB import into nucleus [GO:0042346]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type III interferon production [GO:0034346]; regulation of dendritic cell cytokine production [GO:0002730]; response to exogenous dsRNA [GO:0043330]; signal transduction [GO:0007165]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666] GO:0000139; GO:0002224; GO:0002282; GO:0002730; GO:0002756; GO:0003725; GO:0004872; GO:0004888; GO:0005622; GO:0005737; GO:0005765; GO:0005769; GO:0005789; GO:0005887; GO:0006954; GO:0006972; GO:0007165; GO:0007249; GO:0007250; GO:0007252; GO:0008584; GO:0009597; GO:0010008; GO:0010628; GO:0016020; GO:0032722; GO:0032728; GO:0032735; GO:0032755; GO:0032757; GO:0032760; GO:0034123; GO:0034128; GO:0034138; GO:0034346; GO:0035458; GO:0035666; GO:0035690; GO:0036020; GO:0042346; GO:0042742; GO:0042802; GO:0043065; GO:0043330; GO:0045078; GO:0045080; GO:0045087; GO:0045356; GO:0045359; GO:0045671; GO:0045944; GO:0046330; GO:0050729; GO:0051092; GO:0051607; GO:0070266; GO:0071260; GO:0071346; GO:0071360; GO:0097190; GO:0097191; GO:0097527 0 0 0 PF13516;PF13855;PF01582; P27085 CHOYP_RS26.15.15 m.62867 sp RS26_OCTVU 84.762 105 14 1 4 106 11 115 9.67E-61 185 RS26_OCTVU reviewed 40S ribosomal protein S26 RPS26 Octopus vulgaris (Common octopus) 127 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01283; P34147 CHOYP_BRAFLDRAFT_124528.1.1 m.39621 sp RACA_DICDI 45.221 272 143 2 5 276 323 588 9.67E-78 249 RACA_DICDI reviewed Rho-related protein racA racA DDB_G0286555 Dictyostelium discoideum (Slime mold) 598 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264; GO:0019901 0 0 0 PF00651;PF00071; P48725 CHOYP_LOC100368547.4.40 m.3179 sp PCNT_MOUSE 39.08 174 103 2 1 173 2660 2831 9.67E-29 116 PCNT_MOUSE reviewed Pericentrin Pcnt Pcnt2 Mus musculus (Mouse) 2898 brain morphogenesis [GO:0048854]; camera-type eye development [GO:0043010]; cerebellar cortex morphogenesis [GO:0021696]; cilium assembly [GO:0042384]; embryonic brain development [GO:1990403]; embryonic heart tube development [GO:0035050]; head development [GO:0060322]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; limb morphogenesis [GO:0035108]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural precursor cell proliferation [GO:0061351]; neuron migration [GO:0001764]; olfactory bulb development [GO:0021772]; positive regulation of intracellular protein transport [GO:0090316]; spindle organization [GO:0007051]; vasculature development [GO:0001944] GO:0000226; GO:0000242; GO:0001701; GO:0001764; GO:0001822; GO:0001944; GO:0005813; GO:0005814; GO:0005815; GO:0005874; GO:0007051; GO:0007052; GO:0021696; GO:0021772; GO:0031514; GO:0034451; GO:0035050; GO:0035108; GO:0035264; GO:0036064; GO:0042384; GO:0043010; GO:0043066; GO:0045171; GO:0048854; GO:0060322; GO:0061351; GO:0090316; GO:1990403 0 0 0 PF10495; P55866 CHOYP_contig_033673 m.38294 sp CASP3_XENLA 42.857 56 20 2 4 59 150 193 9.67E-06 45.8 CASP3_XENLA reviewed Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (xCPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] casp3 Xenopus laevis (African clawed frog) 282 apoptotic process [GO:0006915] GO:0004197; GO:0005737; GO:0006915 0 0 0 0 Q14BI2 CHOYP_LOC100374272.1.6 m.8191 sp GRM2_MOUSE 21.542 817 508 30 344 1056 30 817 9.67E-23 108 GRM2_MOUSE reviewed Metabotropic glutamate receptor 2 (mGluR2) Grm2 Gprc1b Mglur2 Mus musculus (Mouse) 872 "glutamate secretion [GO:0014047]; regulation of synaptic transmission, glutamatergic [GO:0051966]" GO:0001641; GO:0005246; GO:0005622; GO:0005887; GO:0014047; GO:0030054; GO:0030424; GO:0030425; GO:0042734; GO:0043005; GO:0051966 0 0 0 PF00003;PF01094;PF07562; Q2TBI2 CHOYP_LOC100640513.1.1 m.51191 sp THAP4_BOVIN 37.037 108 60 3 29 129 1 107 9.67E-11 67.8 THAP4_BOVIN reviewed THAP domain-containing protein 4 THAP4 Bos taurus (Bovine) 584 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q3ZBR5 CHOYP_TTC1.2.2 m.60701 sp TTC1_BOVIN 48.148 270 121 2 4 254 22 291 9.67E-80 244 TTC1_BOVIN reviewed Tetratricopeptide repeat protein 1 (TPR repeat protein 1) TTC1 Bos taurus (Bovine) 292 0 GO:0005778 0 0 0 PF00515; Q5U4U6 CHOYP_LOC589461.1.1 m.59707 sp T23O_XENLA 33.758 314 189 7 8 305 40 350 9.67E-46 163 T23O_XENLA reviewed "Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)" tdo2 Xenopus laevis (African clawed frog) 406 tryptophan catabolic process to kynurenine [GO:0019441] GO:0004833; GO:0019441; GO:0020037; GO:0046872 PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}. 0 0 PF03301; Q96NA8 CHOYP_LOC101158928.1.1 m.20730 sp TSNA1_HUMAN 28.421 95 64 1 46 140 122 212 9.67E-07 53.9 TSNA1_HUMAN reviewed t-SNARE domain-containing protein 1 TSNARE1 Homo sapiens (Human) 513 intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906] GO:0000149; GO:0005484; GO:0006886; GO:0006906; GO:0012505; GO:0016021; GO:0031201; GO:0048278 0 0 0 PF13873;PF05739; Q9BXJ4 CHOYP_C1QT3.2.8 m.20299 sp C1QT3_HUMAN 27.607 163 105 6 25 178 84 242 9.67E-08 53.5 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; O88488 CHOYP_LOC100491367.2.3 m.38110 sp PTPRQ_RAT 26.769 325 172 10 34 301 386 701 9.68E-15 80.5 PTPRQ_RAT reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1) (rPTP-GMC1) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) Ptprq Ptpgmc1 Rattus norvegicus (Rat) 2302 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0005886; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; P10079 CHOYP_EGF1.1.2 m.46366 sp FBP1_STRPU 48.63 292 136 5 1 291 269 547 9.68E-72 253 FBP1_STRPU reviewed Fibropellin-1 (Epidermal growth factor-related protein 1) (Fibropellin-I) (SpEGF I) (UEGF-1) EGF1 Strongylocentrotus purpuratus (Purple sea urchin) 1064 0 GO:0005509; GO:0005615; GO:0016023; GO:0032579 0 0 0 PF01382;PF00431;PF00008;PF12661; P11465 CHOYP_LOC101172646.2.2 m.41826 sp PSG2_HUMAN 26.471 272 145 15 127 376 37 275 9.68E-07 55.1 PSG2_HUMAN reviewed Pregnancy-specific beta-1-glycoprotein 2 (PS-beta-G-2) (PSBG-2) (Pregnancy-specific glycoprotein 2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E) PSG2 PSBG2 Homo sapiens (Human) 335 cell migration [GO:0016477]; female pregnancy [GO:0007565] GO:0005576; GO:0007565; GO:0016477 0 0 0 PF13895;PF07686; P18124 CHOYP_BRAFLDRAFT_125387.2.2 m.25520 sp RL7_HUMAN 64.557 237 84 0 12 248 5 241 9.68E-105 306 RL7_HUMAN reviewed 60S ribosomal protein L7 RPL7 Homo sapiens (Human) 248 "cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]; viral transcription [GO:0019083]" GO:0000184; GO:0000463; GO:0002181; GO:0003677; GO:0003723; GO:0003729; GO:0003735; GO:0005634; GO:0005730; GO:0005737; GO:0005829; GO:0005844; GO:0005925; GO:0006364; GO:0006412; GO:0006413; GO:0006614; GO:0016020; GO:0019083; GO:0022625; GO:0030529; GO:0042273; GO:0042803; GO:0044822; GO:0070062 0 0 0 PF00327;PF08079; P49446 CHOYP_BRAFLDRAFT_248550.1.1 m.41615 sp PTPRE_MOUSE 28.01 407 269 11 12 400 287 687 9.68E-39 151 PTPRE_MOUSE reviewed Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) Ptpre Ptpe Mus musculus (Mouse) 699 negative regulation of insulin receptor signaling pathway [GO:0046627]; regulation of mast cell activation [GO:0033003]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185] GO:0004725; GO:0005634; GO:0005737; GO:0005886; GO:0007185; GO:0016021; GO:0033003; GO:0042803; GO:0046627 0 0 0 PF00102; Q32KR8 CHOYP_BRAFLDRAFT_212086.2.11 m.21334 sp ADPRH_BOVIN 57.621 269 110 2 1 268 87 352 9.68E-102 308 ADPRH_BOVIN reviewed [Protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase) (EC 3.2.2.19) (ADP-ribose-L-arginine cleaving enzyme) ADPRH ARH1 Bos taurus (Bovine) 353 cellular protein modification process [GO:0006464]; protein de-ADP-ribosylation [GO:0051725] GO:0000287; GO:0003875; GO:0005622; GO:0006464; GO:0051725 0 0 0 PF03747; Q9R1R2 CHOYP_TRIM2.10.59 m.20362 sp TRIM3_MOUSE 25.781 256 169 9 115 357 484 731 9.68E-11 67 TRIM3_MOUSE reviewed Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1) Trim3 Hac1 Rnf22 Mus musculus (Mouse) 744 protein transport [GO:0015031]; protein ubiquitination [GO:0016567] GO:0004842; GO:0005737; GO:0005769; GO:0008270; GO:0015031; GO:0016567; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; F7D3V9 CHOYP_LRIG1.1.3 m.954 sp LGR5_XENTR 29.386 456 255 20 1 403 9 450 9.69E-22 102 LGR5_XENTR reviewed Leucine-rich repeat-containing G-protein coupled receptor 5 lgr5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 902 G-protein coupled receptor signaling pathway [GO:0007186]; positive regulation of canonical Wnt signaling pathway [GO:0090263] GO:0004888; GO:0005887; GO:0007186; GO:0032588; GO:0090263 0 0 0 PF13855; O75095 CHOYP_MEGF6.38.59 m.45286 sp MEGF6_HUMAN 37.097 124 66 4 12 135 1150 1261 9.69E-14 70.1 MEGF6_HUMAN reviewed Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3) MEGF6 EGFL3 KIAA0815 Homo sapiens (Human) 1541 0 GO:0005509; GO:0005576 0 0 0 PF07645;PF12661;PF00053; P18172 CHOYP_LOC661056.1.1 m.63204 sp DHGL_DROPS 51.938 129 60 1 39 167 65 191 9.69E-37 137 DHGL_DROPS reviewed "Glucose dehydrogenase [FAD, quinone] (EC 1.1.5.9) [Cleaved into: Glucose dehydrogenase [FAD, quinone] short protein]" Gld GA11047 Drosophila pseudoobscura pseudoobscura (Fruit fly) 625 0 GO:0005576; GO:0016614; GO:0050660 0 0 0 PF05199;PF00732; Q1LZ74 CHOYP_OARD1.1.1 m.4905 sp OARD1_BOVIN 62.791 129 48 0 3 131 4 132 9.69E-55 171 OARD1_BOVIN reviewed O-acetyl-ADP-ribose deacetylase 1 (EC 3.5.1.-) OARD1 Bos taurus (Bovine) 152 purine nucleoside metabolic process [GO:0042278] GO:0001883; GO:0019213; GO:0042278 0 0 0 PF01661; Q03355 CHOYP_PER.1.1 m.18014 sp PER_DROSI 29.975 397 241 9 68 455 166 534 9.70E-49 188 PER_DROSI reviewed Period circadian protein (Fragments) per Drosophila simulans (Fruit fly) 656 "regulation of transcription, DNA-templated [GO:0006355]; rhythmic process [GO:0048511]" GO:0005634; GO:0006355; GO:0048471; GO:0048511 0 0 0 PF00989; Q62388 CHOYP_ATM.1.1 m.45890 sp ATM_MOUSE 33.154 371 240 3 4 373 5 368 9.70E-71 244 ATM_MOUSE reviewed Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T mutated homolog) Atm Mus musculus (Mouse) 3066 "brain development [GO:0007420]; cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to nitrosative stress [GO:0071500]; determination of adult lifespan [GO:0008340]; DNA damage checkpoint [GO:0000077]; DNA damage induced protein phosphorylation [GO:0006975]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; establishment of RNA localization to telomere [GO:0097694]; female gamete generation [GO:0007292]; heart development [GO:0007507]; histone mRNA catabolic process [GO:0071044]; histone phosphorylation [GO:0016572]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; lipoprotein catabolic process [GO:0042159]; meiotic telomere clustering [GO:0045141]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of telomere capping [GO:1904354]; negative regulation of TORC1 signaling [GO:1904262]; neuron apoptotic process [GO:0051402]; oocyte development [GO:0048599]; peptidyl-serine autophosphorylation [GO:0036289]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; positive regulation of histone phosphorylation [GO:0033129]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of telomerase catalytic core complex assembly [GO:1904884]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; pre-B cell allelic exclusion [GO:0002331]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; replicative senescence [GO:0090399]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; signal transduction involved in mitotic G2 DNA damage checkpoint [GO:0072434]; somitogenesis [GO:0001756]; telomere maintenance via telomerase [GO:0007004]; V(D)J recombination [GO:0033151]" GO:0000077; GO:0000724; GO:0000781; GO:0001666; GO:0001756; GO:0002331; GO:0003677; GO:0004672; GO:0004674; GO:0004677; GO:0005524; GO:0005634; GO:0005654; GO:0005819; GO:0006281; GO:0006468; GO:0006974; GO:0006975; GO:0007004; GO:0007050; GO:0007094; GO:0007292; GO:0007420; GO:0007507; GO:0008340; GO:0008630; GO:0010212; GO:0010506; GO:0016023; GO:0016301; GO:0016303; GO:0016572; GO:0018105; GO:0030889; GO:0032212; GO:0032403; GO:0033129; GO:0033151; GO:0036289; GO:0042159; GO:0043065; GO:0043517; GO:0043525; GO:0045141; GO:0046777; GO:0046983; GO:0047485; GO:0048599; GO:0051402; GO:0071044; GO:0071480; GO:0071500; GO:0072434; GO:0090399; GO:0097694; GO:1904262; GO:1904354; GO:1904358; GO:1904884; GO:1990391 0 0 0 PF02259;PF02260;PF00454;PF11640; Q20191 CHOYP_LOC100176264.2.2 m.48731 sp NAS13_CAEEL 43.75 176 94 4 13 187 150 321 9.71E-38 143 NAS13_CAEEL reviewed Zinc metalloproteinase nas-13 (EC 3.4.24.21) (Nematode astacin 13) nas-13 F39D8.4 Caenorhabditis elegans 450 0 GO:0004222; GO:0005576; GO:0008270 0 0 0 PF01400;PF01549; Q61858 CHOYP_BRAFLDRAFT_64382.1.2 m.8051 sp GPAN1_MOUSE 31.594 345 209 10 5 331 30 365 9.71E-49 172 GPAN1_MOUSE reviewed G patch domain and ankyrin repeat-containing protein 1 (G5 protein) (HLA-B-associated transcript 4) Gpank1 Bat-4 Bat4 G5 Mus musculus (Mouse) 372 0 GO:0003676 0 0 0 PF01585; Q7ZWE9 CHOYP_LOC100123907.1.1 m.2987 sp KCY_DANRE 62.827 191 66 1 3 188 2 192 9.71E-80 238 KCY_DANRE reviewed UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) cmpk cmpk1 Danio rerio (Zebrafish) (Brachydanio rerio) 196 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; nucleoside diphosphate phosphorylation [GO:0006165]; nucleoside triphosphate biosynthetic process [GO:0009142]; pyrimidine nucleotide biosynthetic process [GO:0006221] GO:0004127; GO:0004550; GO:0005524; GO:0005634; GO:0005737; GO:0006165; GO:0006207; GO:0006221; GO:0009041; GO:0009142 0 0 cd01428; 0 Q8Q0U0 CHOYP_ANR50.3.3 m.49714 sp Y045_METMA 34.973 183 107 1 98 280 115 285 9.71E-26 108 Y045_METMA reviewed Putative ankyrin repeat protein MM_0045 MM_0045 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 360 0 0 0 0 0 PF12796; Q9DA19 CHOYP_CIR1.2.2 m.35222 sp CIR1_MOUSE 55.983 234 90 4 1 223 1 232 9.71E-80 257 CIR1_MOUSE reviewed Corepressor interacting with RBPJ 1 (CBF1-interacting corepressor) Cir1 Cir Mus musculus (Mouse) 450 "mRNA processing [GO:0006397]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]" GO:0000118; GO:0000122; GO:0005634; GO:0005737; GO:0005815; GO:0006351; GO:0006397; GO:0008380; GO:0016607; GO:0042826; GO:0045892; GO:0045944 0 0 0 PF10197; A4IF63 CHOYP_TRIM2.2.59 m.415 sp TRIM2_BOVIN 23.793 290 171 10 63 305 443 729 9.72E-07 53.5 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O04714 CHOYP_BRAFLDRAFT_117719.1.3 m.16223 sp GCR1_ARATH 30.153 262 172 7 38 292 22 279 9.72E-24 102 GCR1_ARATH reviewed G-protein coupled receptor 1 GCR1 At1g48270 F11A17.17 Arabidopsis thaliana (Mouse-ear cress) 326 abscisic acid-activated signaling pathway [GO:0009738]; activation of phospholipase C activity [GO:0007202]; blue light signaling pathway [GO:0009785]; brassinosteroid mediated signaling pathway [GO:0009742]; cell surface receptor signaling pathway [GO:0007166]; cytokinin-activated signaling pathway [GO:0009736]; flower development [GO:0009908]; gibberellic acid mediated signaling pathway [GO:0009740]; lipid metabolic process [GO:0006629]; L-phenylalanine biosynthetic process [GO:0009094]; maintenance of seed dormancy [GO:0010231]; mitotic cell cycle [GO:0000278]; negative regulation of abscisic acid-activated signaling pathway [GO:0009788]; positive regulation of gibberellic acid mediated signaling pathway [GO:0009939]; regulation of inositol trisphosphate biosynthetic process [GO:0032960]; response to cytokinin [GO:0009735]; response to low fluence blue light stimulus by blue low-fluence system [GO:0010244]; seed germination [GO:0009845]; tyrosine biosynthetic process [GO:0006571] GO:0000278; GO:0004930; GO:0005774; GO:0005794; GO:0005886; GO:0006571; GO:0006629; GO:0007166; GO:0007202; GO:0009094; GO:0009735; GO:0009736; GO:0009738; GO:0009740; GO:0009742; GO:0009785; GO:0009788; GO:0009845; GO:0009908; GO:0009939; GO:0010231; GO:0010244; GO:0032960; GO:0044214 0 0 0 0 O70277 CHOYP_BRAFLDRAFT_87325.6.11 m.24154 sp TRIM3_RAT 22.515 342 200 13 171 466 422 744 9.72E-08 58.2 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P04569 CHOYP_AAEL_AAEL010792.1.2 m.44974 sp SCP1_BRALA 31.522 92 63 0 12 103 2 93 9.72E-09 53.9 SCP1_BRALA reviewed "Sarcoplasmic calcium-binding proteins I, III, and IV (SCP I, III, IV)" 0 Branchiostoma lanceolatum (Common lancelet) (Amphioxus lanceolatum) 185 0 GO:0005509 0 0 0 PF13202;PF13499; P78329 CHOYP_CP4F2.1.1 m.7802 sp CP4F2_HUMAN 28.792 389 238 10 78 427 113 501 9.72E-29 122 CP4F2_HUMAN reviewed Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.13.194) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.13.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.13.30) CYP4F2 Homo sapiens (Human) 520 arachidonic acid metabolic process [GO:0019369]; blood coagulation [GO:0007596]; drug metabolic process [GO:0017144]; epoxygenase P450 pathway [GO:0019373]; icosanoid metabolic process [GO:0006690]; leukotriene B4 catabolic process [GO:0036101]; leukotriene metabolic process [GO:0006691]; long-chain fatty acid metabolic process [GO:0001676]; menaquinone catabolic process [GO:0042361]; negative regulation of icosanoid secretion [GO:0032304]; omega-hydroxylase P450 pathway [GO:0097267]; oxidation-reduction process [GO:0055114]; phylloquinone catabolic process [GO:0042376]; positive regulation of icosanoid secretion [GO:0032305]; pressure natriuresis [GO:0003095]; regulation of blood pressure [GO:0008217]; renal water homeostasis [GO:0003091]; sodium ion homeostasis [GO:0055078]; very long-chain fatty acid metabolic process [GO:0000038]; vitamin E metabolic process [GO:0042360]; vitamin K catabolic process [GO:0042377] GO:0000038; GO:0001676; GO:0003091; GO:0003095; GO:0004497; GO:0005506; GO:0005737; GO:0005789; GO:0006690; GO:0006691; GO:0007596; GO:0008217; GO:0008392; GO:0016324; GO:0016709; GO:0017144; GO:0018685; GO:0019369; GO:0019373; GO:0020037; GO:0031090; GO:0032304; GO:0032305; GO:0036101; GO:0042360; GO:0042361; GO:0042376; GO:0042377; GO:0043231; GO:0050051; GO:0052869; GO:0052871; GO:0052872; GO:0055078; GO:0055114; GO:0097258; GO:0097259; GO:0097267 PATHWAY: Cofactor degradation; phylloquinone degradation. {ECO:0000269|PubMed:24138531}. 0 0 PF00067; Q69ZS0 CHOYP_LOC100375683.1.1 m.10289 sp PZRN3_MOUSE 41.221 131 72 3 1 128 1 129 9.72E-26 111 PZRN3_MOUSE reviewed E3 ubiquitin-protein ligase PDZRN3 (EC 6.3.2.-) (PDZ domain-containing RING finger protein 3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) Pdzrn3 Kiaa1095 Semcap3 Mus musculus (Mouse) 1063 neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567] GO:0004842; GO:0007528; GO:0008270; GO:0016567; GO:0016874; GO:0031594; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00595; Q8N2E2 CHOYP_NEMVEDRAFT_V1G214844.8.34 m.21843 sp VWDE_HUMAN 23.664 655 389 31 15 609 12 615 9.72E-21 102 VWDE_HUMAN reviewed von Willebrand factor D and EGF domain-containing protein VWDE Homo sapiens (Human) 1590 0 GO:0005576 0 0 0 PF00094; Q8NE09 CHOYP_RGS22.2.2 m.59114 sp RGS22_HUMAN 38.977 821 429 13 501 1311 404 1162 9.72E-177 567 RGS22_HUMAN reviewed Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) 1264 negative regulation of signal transduction [GO:0009968] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0009968 0 0 0 PF00615; Q8WZ42 CHOYP_HSPG2.3.4 m.22158 sp TITIN_HUMAN 24.128 717 441 30 59 752 7020 7656 9.72E-27 123 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; O75382 CHOYP_BRAFLDRAFT_88224.2.11 m.3212 sp TRIM3_HUMAN 25.954 262 172 10 308 555 489 742 9.73E-11 68.2 TRIM3_HUMAN reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) (RING finger protein 97) TRIM3 BERP RNF22 RNF97 Homo sapiens (Human) 744 nervous system development [GO:0007399]; protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0007399; GO:0008022; GO:0008270; GO:0015031; GO:0061630 0 0 0 PF00630;PF01436;PF00643;PF13445; P29314 CHOYP_RS9.8.13 m.41198 sp RS9_RAT 90.116 172 13 1 5 172 1 172 9.73E-108 310 RS9_RAT reviewed 40S ribosomal protein S9 Rps9 Rattus norvegicus (Rat) 194 positive regulation of translational fidelity [GO:0045903]; translation [GO:0006412] GO:0003735; GO:0006412; GO:0022627; GO:0030529; GO:0045903; GO:1990932 0 0 0 PF00163;PF01479; Q12718 CHOYP_LOC724890.1.1 m.49565 sp LAC2_TRAVE 29.928 558 284 20 87 626 35 503 9.73E-58 207 LAC2_TRAVE reviewed Laccase-2 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase 2) (Diphenol oxidase 2) (Laccase I) (Urishiol oxidase 2) LCC2 LCCI Trametes versicolor (White-rot fungus) (Coriolus versicolor) 519 lignin catabolic process [GO:0046274] GO:0005507; GO:0005576; GO:0046274; GO:0052716 0 0 0 PF00394;PF07731;PF07732; Q4KLN4 CHOYP_BRAFLDRAFT_64464.2.2 m.58674 sp GLE1_RAT 31.901 605 356 17 182 772 133 695 9.73E-80 273 GLE1_RAT reviewed Nucleoporin GLE1 (GLE1-like protein) Gle1 Gle1l Rattus norvegicus (Rat) 698 mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; protein transport [GO:0015031]; regulation of translational initiation [GO:0006446]; regulation of translational termination [GO:0006449] GO:0000822; GO:0005543; GO:0005737; GO:0006406; GO:0006446; GO:0006449; GO:0015031; GO:0016973; GO:0031369; GO:0044614 0 0 0 PF07817; Q6GLB9 CHOYP_EMX1.2.2 m.59298 sp EMX1_XENTR 56.25 128 32 5 108 218 78 198 9.73E-31 117 EMX1_XENTR reviewed Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1) emx1 TNeu052k18.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 233 "multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]" GO:0005634; GO:0006355; GO:0007275; GO:0043565 0 0 0 PF00046; Q9H479 CHOYP_FN3K.1.1 m.15531 sp FN3K_HUMAN 57.878 311 125 5 1 307 1 309 9.73E-126 364 FN3K_HUMAN reviewed Fructosamine-3-kinase (EC 2.7.1.-) FN3K Homo sapiens (Human) 309 epithelial cell differentiation [GO:0030855]; fructosamine metabolic process [GO:0030389]; fructoselysine metabolic process [GO:0030393]; post-translational protein modification [GO:0043687] GO:0005829; GO:0016301; GO:0030387; GO:0030389; GO:0030393; GO:0030855; GO:0043687 0 0 0 PF03881; Q9JIX8 CHOYP_ACIN1A.1.2 m.45772 sp ACINU_MOUSE 40 430 189 13 576 975 844 1234 9.73E-61 231 ACINU_MOUSE reviewed Apoptotic chromatin condensation inducer in the nucleus (Acinus) Acin1 Acinus Mus musculus (Mouse) 1338 "apoptotic chromosome condensation [GO:0030263]; apoptotic process [GO:0006915]; erythrocyte differentiation [GO:0030218]; mitophagy in response to mitochondrial depolarization [GO:0098779]; mRNA processing [GO:0006397]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of apoptotic process [GO:0043065]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of monocyte differentiation [GO:0045657]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]; xenophagy [GO:0098792]" GO:0000166; GO:0002230; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005886; GO:0006397; GO:0006915; GO:0008380; GO:0016607; GO:0030218; GO:0030263; GO:0035145; GO:0042981; GO:0043065; GO:0044822; GO:0045657; GO:0048025; GO:0061574; GO:0098779; GO:0098792 0 0 0 PF16294;PF02037; Q9VFB2 CHOYP_RT10.3.4 m.15497 sp RT10_DROME 45.89 146 72 2 40 180 25 168 9.73E-36 133 RT10_DROME reviewed "28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt)" mRpS10 CG4247 Drosophila melanogaster (Fruit fly) 173 sensory perception of pain [GO:0019233]; translation [GO:0006412] GO:0003735; GO:0005739; GO:0005763; GO:0006412; GO:0019233 0 0 0 PF00338; A4IF63 CHOYP_BRAFLDRAFT_87285.2.8 m.39263 sp TRIM2_BOVIN 26 150 109 2 88 236 595 743 9.74E-09 58.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O96064 CHOYP_MYSP.1.9 m.1099 sp MYSP_MYTGA 64.789 142 49 1 5 146 227 367 9.74E-52 179 MYSP_MYTGA reviewed Paramyosin 0 Mytilus galloprovincialis (Mediterranean mussel) 864 0 GO:0003774; GO:0030016; GO:0032982 0 0 0 PF01576; P30151 CHOYP_EF1B.3.7 m.35082 sp EF1B_XENLA 64.894 188 59 2 88 268 1 188 9.74E-78 238 EF1B_XENLA reviewed Elongation factor 1-beta (EF-1-beta) (p30) eef1b Xenopus laevis (African clawed frog) 227 0 GO:0003746; GO:0005853 0 0 cd00292; PF10587;PF00736; P86734 CHOYP_TRIADDRAFT_53531.1.2 m.12127 sp EPDR1_HALAI 26.54 211 121 9 1 191 2 198 9.74E-11 62 EPDR1_HALAI reviewed Ependymin-related protein 1 Sometsuke Haliotis asinina (Donkey's ear abalone) (Ass's ear abalone) 200 cell-matrix adhesion [GO:0007160] GO:0005509; GO:0005576; GO:0007160 0 0 0 PF00811; Q6TFL4 CHOYP_KLH29.1.1 m.31861 sp KLH24_HUMAN 30.237 549 361 9 27 567 58 592 9.74E-72 244 KLH24_HUMAN reviewed Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) KLHL24 DRE1 Homo sapiens (Human) 600 protein ubiquitination [GO:0016567]; regulation of kainate selective glutamate receptor activity [GO:2000312] GO:0005737; GO:0016567; GO:0030424; GO:0031463; GO:0043204; GO:2000312 0 0 0 PF07707;PF00651;PF01344; Q8IS44 CHOYP_DRD2L.1.1 m.31820 sp DRD2L_DROME 44.444 477 211 13 124 594 75 503 9.74E-121 369 DRD2L_DROME reviewed Dopamine D2-like receptor (DD2R) Dop2R D2R CG17004 Drosophila melanogaster (Fruit fly) 506 "dopamine receptor signaling pathway [GO:0007212]; G-protein coupled receptor signaling pathway [GO:0007186]; synaptic transmission, dopaminergic [GO:0001963]" GO:0001588; GO:0001963; GO:0004930; GO:0004952; GO:0005887; GO:0007186; GO:0007212; GO:0008227; GO:0016021; GO:0035240 0 0 0 PF00001; Q9BKZ9 CHOYP_PHUM_PHUM122670.1.1 m.38346 sp FEH1_CAEEL 43.75 432 187 12 230 655 235 616 9.74E-114 360 FEH1_CAEEL reviewed Protein Fe65 homolog feh-1 Y54F10AM.2 Caenorhabditis elegans 665 "embryo development ending in birth or egg hatching [GO:0009792]; feeding behavior [GO:0007631]; nematode larval development [GO:0002119]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0001540; GO:0002119; GO:0005634; GO:0005737; GO:0005856; GO:0006351; GO:0006355; GO:0007631; GO:0008134; GO:0009792 0 0 0 PF00640; P19217 CHOYP_ST1B1.4.4 m.57717 sp ST1E1_BOVIN 33.681 288 161 10 53 325 17 289 9.75E-42 149 ST1E1_BOVIN reviewed "Estrogen sulfotransferase (EC 2.8.2.4) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)" SULT1E1 OST STE Bos taurus (Bovine) 295 estrogen metabolic process [GO:0008210] GO:0004304; GO:0005496; GO:0005737; GO:0008210; GO:0050294 0 0 0 PF00685; P20825 CHOYP_LOC754701.2.7 m.12853 sp POL2_DROME 39.232 469 268 8 266 723 161 623 9.75E-100 333 POL2_DROME reviewed Retrovirus-related Pol polyprotein from transposon 297 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] pol Drosophila melanogaster (Fruit fly) 1059 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00078; P58375 CHOYP_LOC100907054.2.2 m.30488 sp RL30_SPOFR 80.357 56 11 0 26 81 1 56 9.75E-25 93.2 RL30_SPOFR reviewed 60S ribosomal protein L30 RpL30 Spodoptera frugiperda (Fall armyworm) 113 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01248; Q5RBB1 CHOYP_LOC592825.1.1 m.43751 sp SENP1_PONAB 45.886 316 158 4 418 720 330 645 9.75E-93 305 SENP1_PONAB reviewed Sentrin-specific protease 1 (EC 3.4.22.68) (Sentrin/SUMO-specific protease SENP1) SENP1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 645 protein desumoylation [GO:0016926] GO:0005634; GO:0005737; GO:0016926; GO:0016929 0 0 0 PF02902; Q5XJ85 CHOYP_MYD88.4.7 m.31202 sp MYD88_DANRE 37 100 56 3 7 106 4 96 9.75E-14 68.2 MYD88_DANRE reviewed Myeloid differentiation primary response protein MyD88 myd88 Danio rerio (Zebrafish) (Brachydanio rerio) 284 activation of innate immune response [GO:0002218]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; neutrophil chemotaxis [GO:0030593]; positive regulation of hematopoietic progenitor cell differentiation [GO:1901534]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]; response to molecule of bacterial origin [GO:0002237] GO:0002218; GO:0002237; GO:0002755; GO:0005737; GO:0006954; GO:0030593; GO:0043123; GO:0045087; GO:1901532; GO:1901534 0 0 0 PF00531;PF01582; Q5ZIL6 CHOYP_LOC100376143.1.1 m.25735 sp TM41B_CHICK 59.387 261 105 1 24 283 3 263 9.75E-113 328 TM41B_CHICK reviewed Transmembrane protein 41B TMEM41B RCJMB04_25c20 Gallus gallus (Chicken) 269 nervous system development [GO:0007399] GO:0007399; GO:0016021 0 0 0 PF09335; Q642B6 CHOYP_LOC584740.1.2 m.25272 sp THAP4_RAT 33.884 121 62 5 7 114 5 120 9.75E-08 58.2 THAP4_RAT reviewed THAP domain-containing protein 4 Thap4 Rattus norvegicus (Rat) 569 0 GO:0003677; GO:0046872 0 0 cd07828; PF08768;PF05485; Q7RTX9 CHOYP_LOC100881530.1.1 m.51085 sp MOT14_HUMAN 35.714 280 169 5 40 312 21 296 9.75E-45 171 MOT14_HUMAN reviewed Monocarboxylate transporter 14 (MCT 14) (Solute carrier family 16 member 14) SLC16A14 MCT14 Homo sapiens (Human) 510 0 GO:0005886; GO:0008028; GO:0015293; GO:0016021 0 0 cd06174; PF07690; Q922B6 CHOYP_LOC100636817.1.1 m.36715 sp TRAF7_MOUSE 33.449 577 329 17 25 585 55 592 9.75E-93 300 TRAF7_MOUSE reviewed E3 ubiquitin-protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor-associated factor 7) Traf7 Mus musculus (Mouse) 594 "activation of MAPKKK activity [GO:0000185]; apoptotic process [GO:0006915]; cellular response to interleukin-6 [GO:0071354]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein sumoylation [GO:0033235]; protein ubiquitination [GO:0016567]; regulation of protein localization [GO:0032880]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0000151; GO:0000185; GO:0004842; GO:0005634; GO:0005829; GO:0005886; GO:0006351; GO:0006915; GO:0008270; GO:0016023; GO:0016567; GO:0016874; GO:0032880; GO:0033235; GO:0043231; GO:0043410; GO:0048471; GO:0071354; GO:2001235 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400;PF13445; Q9NUV9 CHOYP_LOC100932386.1.1 m.63859 sp GIMA4_HUMAN 37.132 272 155 5 18 276 22 290 9.75E-49 173 GIMA4_HUMAN reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4) GIMAP4 IAN1 IMAP4 MSTP062 Homo sapiens (Human) 329 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9QYY0 CHOYP_ISCW_ISCW017526.1.2 m.24672 sp GAB1_MOUSE 29.825 285 148 11 5 263 4 262 9.75E-19 94 GAB1_MOUSE reviewed GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) Gab1 Mus musculus (Mouse) 695 activation of JUN kinase activity [GO:0007257]; activation of MAPK activity [GO:0000187]; epidermal growth factor receptor signaling pathway [GO:0007173]; epidermis development [GO:0008544]; heart development [GO:0007507]; interleukin-6-mediated signaling pathway [GO:0070102]; labyrinthine layer development [GO:0060711]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of MAPK cascade [GO:0043410]; regulation of cell migration [GO:0030334]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165] GO:0000187; GO:0004871; GO:0005737; GO:0006979; GO:0007165; GO:0007173; GO:0007257; GO:0007507; GO:0008544; GO:0030334; GO:0043410; GO:0048008; GO:0060711; GO:0070102 0 0 0 PF00169; P08021 CHOYP_FMRF.2.4 m.37050 sp FMRF_APLCA 37.791 172 76 11 126 288 243 392 9.76E-07 53.5 FMRF_APLCA reviewed FMRF-amide neuropeptides [Cleaved into: FLRF-amide; FMRF-amide] 0 Aplysia californica (California sea hare) 597 neuropeptide signaling pathway [GO:0007218] GO:0005576; GO:0007218 0 0 0 PF01581; P15989 CHOYP_contig_002349 m.2582 sp CO6A3_CHICK 42.478 113 47 2 12 106 2176 2288 9.76E-15 75.9 CO6A3_CHICK reviewed Collagen alpha-3(VI) chain COL6A3 Gallus gallus (Chicken) 3137 cell adhesion [GO:0007155] GO:0004867; GO:0005578; GO:0005581; GO:0007155 0 0 0 PF01391;PF00014;PF00092; P51521 CHOYP_LOC100907674.1.1 m.66207 sp OVO_DROME 71.333 150 39 1 214 359 1186 1335 9.76E-68 235 OVO_DROME reviewed Protein ovo (Protein shaven baby) ovo Svb CG6824 Drosophila melanogaster (Fruit fly) 1351 "adult feeding behavior [GO:0008343]; cuticle development [GO:0042335]; cuticle pattern formation [GO:0035017]; cuticle pigmentation [GO:0048067]; cytoskeleton organization [GO:0007010]; epidermal cell differentiation [GO:0009913]; female germ-line sex determination [GO:0019099]; germ-line sex determination [GO:0018992]; imaginal disc-derived leg joint morphogenesis [GO:0016348]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; non-sensory hair organization [GO:0035316]; oogenesis [GO:0048477]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transposon integration [GO:0070896]; regulation of cell shape [GO:0008360]; regulation of transcription, DNA-templated [GO:0006355]; transcription from RNA polymerase II promoter [GO:0006366]" GO:0000122; GO:0000981; GO:0003677; GO:0005634; GO:0005737; GO:0006355; GO:0006366; GO:0007010; GO:0008343; GO:0008360; GO:0009913; GO:0016348; GO:0018992; GO:0019099; GO:0035017; GO:0035316; GO:0042335; GO:0043565; GO:0045892; GO:0045893; GO:0045944; GO:0046872; GO:0048067; GO:0048477; GO:0070896 0 0 0 0 Q4VBS4 CHOYP_LOC100083996.1.1 m.14042 sp MAP12_DANRE 51.385 325 145 4 5 328 25 337 9.76E-100 300 MAP12_DANRE reviewed "Methionine aminopeptidase 1D, mitochondrial (MAP 1D) (MetAP 1D) (EC 3.4.11.18) (Methionyl aminopeptidase type 1D, mitochondrial) (Peptidase M 1D)" metap1d map1d zgc:110461 Danio rerio (Zebrafish) (Brachydanio rerio) 338 protein initiator methionine removal [GO:0070084] GO:0005739; GO:0046872; GO:0070006; GO:0070084 0 0 cd01086; PF00557; Q8WZ42 CHOYP_TTN.4.9 m.26073 sp TITIN_HUMAN 28.947 266 148 12 93 328 20657 20911 9.76E-11 67.8 TITIN_HUMAN reviewed Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) TTN Homo sapiens (Human) 34350 cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941] GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0019899; GO:0019901; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q92609 CHOYP_LOC101078318.1.1 m.45168 sp TBCD5_HUMAN 54.639 388 166 4 70 456 48 426 9.76E-147 452 TBCD5_HUMAN reviewed TBC1 domain family member 5 TBC1D5 KIAA0210 Homo sapiens (Human) 795 "activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of autophagy [GO:0010508]; positive regulation of receptor internalization [GO:0002092]; regulation of vesicle fusion [GO:0031338]; response to starvation [GO:0042594]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0002092; GO:0005096; GO:0005776; GO:0005829; GO:0006886; GO:0010008; GO:0010508; GO:0017137; GO:0030904; GO:0031338; GO:0031410; GO:0035612; GO:0042147; GO:0042594; GO:0090630; GO:0098779 0 0 0 PF00566; Q99MZ8 CHOYP_LOC100201729.1.1 m.58664 sp LASP1_RAT 46.296 270 122 4 1 254 1 263 9.76E-78 238 LASP1_RAT reviewed LIM and SH3 domain protein 1 (LASP-1) Lasp1 Rattus norvegicus (Rat) 263 ion transport [GO:0006811] GO:0005925; GO:0006811; GO:0008270; GO:0015075; GO:0030864; GO:0070062 0 0 0 PF00412;PF00880;PF14604; Q9Y6G5 CHOYP_BRAFLDRAFT_121749.1.1 m.18913 sp COMDA_HUMAN 50.811 185 91 0 11 195 12 196 9.76E-56 179 COMDA_HUMAN reviewed COMM domain-containing protein 10 COMMD10 HSPC305 PTD002 Homo sapiens (Human) 202 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005737; GO:0006351; GO:0006355 0 0 0 PF07258; E2RDZ6 CHOYP_LOC100533524.1.1 m.33932 sp SIR5_CANLF 69.963 273 82 0 41 313 37 309 9.77E-142 405 SIR5_CANLF reviewed "NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 3.5.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)" SIRT5 Canis lupus familiaris (Dog) (Canis familiaris) 310 negative regulation of reactive oxygen species metabolic process [GO:2000378]; protein demalonylation [GO:0036046]; protein desuccinylation [GO:0036048]; regulation of ketone biosynthetic process [GO:0010566] GO:0005634; GO:0005739; GO:0005743; GO:0005758; GO:0005759; GO:0005829; GO:0008270; GO:0010566; GO:0034979; GO:0036046; GO:0036048; GO:0036054; GO:0036055; GO:0061697; GO:0070403; GO:2000378 0 0 cd01412; PF02146; P21613 CHOYP_BRAFLDRAFT_208436.27.32 m.61232 sp KINH_DORPE 55.484 155 56 5 217 371 697 838 9.77E-32 130 KINH_DORPE reviewed Kinesin heavy chain 0 Doryteuthis pealeii (Longfin inshore squid) (Loligo pealeii) 967 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018 0 0 0 PF00225; P24044 CHOYP_LOC100261610.1.1 m.6374 sp CALM_PLAFA 34.459 148 91 2 10 152 3 149 9.77E-24 93.2 CALM_PLAFA reviewed Calmodulin (CaM) 0 Plasmodium falciparum 149 0 GO:0005509 0 0 0 PF13499; P51957 CHOYP_NEK4.1.8 m.3023 sp NEK4_HUMAN 48.638 257 128 4 13 268 11 264 9.77E-70 246 NEK4_HUMAN reviewed Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2) NEK4 STK2 Homo sapiens (Human) 841 "cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; regulation of cellular senescence [GO:2000772]; regulation of replicative cell aging [GO:1900062]; regulation of response to DNA damage stimulus [GO:2001020]" GO:0000278; GO:0004674; GO:0004702; GO:0005524; GO:0005737; GO:0005929; GO:0006468; GO:0006974; GO:0007067; GO:0030145; GO:0045893; GO:0051301; GO:1900062; GO:2000772; GO:2001020 0 0 0 PF00069; P74897 CHOYP_contig_012079 m.13839 sp YQA3_THEAQ 30.612 147 88 4 4 150 3 135 9.77E-11 59.3 YQA3_THEAQ reviewed Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) 0 Thermus aquaticus 137 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; P74897 CHOYP_contig_012079 m.13840 sp YQA3_THEAQ 30.612 147 88 4 4 150 3 135 9.77E-11 59.3 YQA3_THEAQ reviewed Universal stress protein in QAH/OAS sulfhydrylase 3'region (USP) 0 Thermus aquaticus 137 response to stress [GO:0006950] GO:0006950 0 0 0 PF00582; Q09225 CHOYP_BRAFLDRAFT_66621.3.4 m.15436 sp NRF6_CAEEL 26.104 770 456 22 199 910 82 796 9.77E-80 279 NRF6_CAEEL reviewed Nose resistant to fluoxetine protein 6 (Protein nrf-6) nrf-6 C08B11.4 Caenorhabditis elegans 822 lipid transport [GO:0006869]; multicellular organism development [GO:0007275] GO:0006869; GO:0007275; GO:0008289; GO:0016021; GO:0016747 0 0 0 PF01757; Q5EB28 CHOYP_MIDN.2.3 m.5600 sp MIDN_XENTR 33.766 154 67 3 68 190 258 407 9.77E-19 87.4 MIDN_XENTR reviewed Midnolin (Midbrain nucleolar protein) midn TNeu058f14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 453 0 GO:0005730 0 0 0 PF00240; Q8IWZ3 CHOYP_LOC100640442.6.10 m.42046 sp ANKH1_HUMAN 33.868 499 310 15 234 712 207 705 9.77E-56 211 ANKH1_HUMAN reviewed Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK) ANKHD1 KIAA1085 MASK VBARP PP2500 Homo sapiens (Human) 2542 innate immune response [GO:0045087] GO:0005654; GO:0005737; GO:0044822; GO:0045087 0 0 0 PF12796;PF00013; Q8NFW1 CHOYP_CO6A5.5.6 m.46154 sp COMA1_HUMAN 39.063 192 111 3 24 212 31 219 9.77E-31 128 COMA1_HUMAN reviewed Collagen alpha-1(XXII) chain COL22A1 Homo sapiens (Human) 1626 0 GO:0005576; GO:0005578; GO:0005581; GO:0005788 0 0 0 PF01391;PF00092; Q8R3P7 CHOYP_BRAFLDRAFT_119036.1.1 m.18576 sp CLUA1_MOUSE 61.05 362 129 4 1 356 1 356 9.77E-145 420 CLUA1_MOUSE reviewed Clusterin-associated protein 1 Cluap1 Mus musculus (Mouse) 413 axoneme assembly [GO:0035082]; cilium assembly [GO:0042384]; floor plate formation [GO:0021508]; heart looping [GO:0001947]; intraciliary transport [GO:0042073]; left/right pattern formation [GO:0060972]; neural tube closure [GO:0001843]; smoothened signaling pathway [GO:0007224] GO:0001843; GO:0001947; GO:0005654; GO:0005813; GO:0005929; GO:0007224; GO:0021508; GO:0030992; GO:0035082; GO:0042073; GO:0042384; GO:0043231; GO:0060972; GO:0097542; GO:0097546 0 0 0 PF10234; Q9DBX3 CHOYP_CPIPJ_CPIJ017084.1.1 m.51185 sp SUSD2_MOUSE 27.467 750 429 26 297 977 109 812 9.77E-67 243 SUSD2_MOUSE reviewed Sushi domain-containing protein 2 Susd2 Mus musculus (Mouse) 820 immune response [GO:0006955]; negative regulation of cell cycle G1/S phase transition [GO:1902807]; negative regulation of cell division [GO:0051782] GO:0005044; GO:0005886; GO:0006955; GO:0016021; GO:0030247; GO:0051782; GO:0070062; GO:1902807 0 0 0 PF03782;PF01033;PF00084;PF00094; Q9N2M8 CHOYP_LOC100644701.1.2 m.50788 sp HDC_DROME 56.604 106 43 2 43 145 70 175 9.77E-32 128 HDC_DROME reviewed Headcase protein [Cleaved into: Headcase short protein] hdc CG15532 Drosophila melanogaster (Fruit fly) 1080 "axon extension [GO:0048675]; branch fusion, open tracheal system [GO:0035147]; imaginal disc-derived wing morphogenesis [GO:0007476]; instar larval or pupal development [GO:0002165]; negative regulation of neurogenesis [GO:0050768]; negative regulation of terminal cell fate specification, open tracheal system [GO:0035155]; neurogenesis [GO:0022008]; regulation of neuron remodeling [GO:1904799]; RNA interference [GO:0016246]; salivary gland cell autophagic cell death [GO:0035071]; terminal branching, open tracheal system [GO:0007430]" GO:0002165; GO:0005737; GO:0007430; GO:0007476; GO:0016246; GO:0022008; GO:0030424; GO:0030425; GO:0035071; GO:0035147; GO:0035155; GO:0048471; GO:0048675; GO:0050768; GO:1904799 0 0 0 PF16002;PF15353; Q9UPN9 CHOYP_TRIM33.1.1 m.36639 sp TRI33_HUMAN 34.673 398 235 8 14 408 122 497 9.77E-61 229 TRI33_HUMAN reviewed E3 ubiquitin-protein ligase TRIM33 (EC 6.3.2.-) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33) TRIM33 KIAA1113 RFG7 TIF1G Homo sapiens (Human) 1127 "negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0003677; GO:0004842; GO:0005634; GO:0005654; GO:0006351; GO:0008270; GO:0016567; GO:0016874; GO:0017015; GO:0030514; GO:0043231; GO:0045892; GO:0070410; GO:0070412 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00439;PF00628;PF00643;PF13445; B0W2S0 CHOYP_LOC663660.1.1 m.15500 sp CLU_CULQU 76.331 169 39 1 3 170 57 225 9.78E-87 281 CLU_CULQU reviewed Clustered mitochondria protein homolog CPIJ001445 Culex quinquefasciatus (Southern house mosquito) (Culex pungens) 1377 intracellular distribution of mitochondria [GO:0048312] GO:0005737; GO:0048312 0 0 cd15466; PF13236;PF15044;PF05303;PF12807;PF13374; F1M3L7 CHOYP_DSEC_GM16639.1.1 m.66853 sp EPS8_RAT 33.766 385 185 11 13 392 266 585 9.78E-57 202 EPS8_RAT reviewed Epidermal growth factor receptor kinase substrate 8 Eps8 Rattus norvegicus (Rat) 822 actin crosslink formation [GO:0051764]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; actin polymerization-dependent cell motility [GO:0070358]; adult locomotory behavior [GO:0008344]; barbed-end actin filament capping [GO:0051016]; behavioral response to ethanol [GO:0048149]; dendritic cell migration [GO:0036336]; exit from mitosis [GO:0010458]; Rac protein signal transduction [GO:0016601]; regulation of actin filament length [GO:0030832]; regulation of cell shape [GO:0008360] GO:0003779; GO:0005903; GO:0005938; GO:0008344; GO:0008360; GO:0010458; GO:0014069; GO:0016601; GO:0017146; GO:0030054; GO:0030426; GO:0030832; GO:0031532; GO:0032420; GO:0032587; GO:0035591; GO:0036336; GO:0048149; GO:0048365; GO:0051016; GO:0051017; GO:0051764; GO:0070062; GO:0070358 0 0 0 PF08416;PF00018; O06431 CHOYP_CK5_01750.1.1 m.1250 sp DNAJ_NITEU 54.545 66 30 0 60 125 2 67 9.78E-16 79 DNAJ_NITEU reviewed Chaperone protein DnaJ dnaJ NE1948 Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298) 369 DNA replication [GO:0006260]; protein folding [GO:0006457]; response to heat [GO:0009408] GO:0005524; GO:0005737; GO:0006260; GO:0006457; GO:0008270; GO:0009408 0 0 cd06257; PF00226;PF01556;PF00684; P38166 CHOYP_ISCW_ISCW017655.1.1 m.22913 sp SFT2_YEAST 31.98 197 129 2 2 194 7 202 9.78E-33 120 SFT2_YEAST reviewed Protein transport protein SFT2 SFT2 YBL102W YBL0812 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 215 "protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]" GO:0000138; GO:0000139; GO:0005829; GO:0015031; GO:0016021; GO:0042147 0 0 0 PF04178; Q6DC53 CHOYP_CTU2.1.1 m.43200 sp CTU2_DANRE 41.142 508 253 10 15 487 1 497 9.78E-119 361 CTU2_DANRE reviewed Cytoplasmic tRNA 2-thiolation protein 2 ctu2 ncs2 zgc:101113 Danio rerio (Zebrafish) (Brachydanio rerio) 501 protein urmylation [GO:0032447]; tRNA thio-modification [GO:0034227]; tRNA wobble uridine modification [GO:0002098] GO:0000049; GO:0002098; GO:0005829; GO:0016779; GO:0032447; GO:0034227 PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03054}. 0 0 PF10288; Q6DDL7 CHOYP_UNC93A.2.2 m.19367 sp UN93A_XENLA 31.974 466 287 6 288 747 2 443 9.78E-66 228 UN93A_XENLA reviewed Protein unc-93 homolog A (Unc-93A) unc93a Xenopus laevis (African clawed frog) 460 0 GO:0016021 0 0 cd06174; PF05978; Q6RY07 CHOYP_BRAFLDRAFT_281651.5.8 m.25278 sp CHIA_RAT 44.124 485 250 7 7 489 6 471 9.78E-133 399 CHIA_RAT reviewed Acidic mammalian chitinase (AMCase) (EC 3.2.1.14) Chia Rattus norvegicus (Rat) 473 apoptotic process [GO:0006915]; chitin catabolic process [GO:0006032]; immune system process [GO:0002376]; polysaccharide catabolic process [GO:0000272]; positive regulation of chemokine secretion [GO:0090197]; production of molecular mediator involved in inflammatory response [GO:0002532] GO:0000272; GO:0002376; GO:0002532; GO:0004568; GO:0005576; GO:0005615; GO:0005737; GO:0006032; GO:0006915; GO:0008061; GO:0090197 0 0 0 PF01607;PF00704; Q8K0U4 CHOYP_HS12A.6.33 m.29727 sp HS12A_MOUSE 31.587 630 370 10 71 650 56 674 9.78E-98 317 HS12A_MOUSE reviewed Heat shock 70 kDa protein 12A Hspa12a Kiaa0417 Mus musculus (Mouse) 675 0 GO:0005524; GO:0070062 0 0 0 0 Q9UGM1 CHOYP_NEMVEDRAFT_V1G199721.1.1 m.64387 sp ACHA9_HUMAN 32.338 201 131 2 41 236 34 234 9.78E-33 127 ACHA9_HUMAN reviewed Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9) CHRNA9 NACHRA9 Homo sapiens (Human) 479 "detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; inner ear morphogenesis [GO:0042472]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; synaptic transmission, cholinergic [GO:0007271]" GO:0004889; GO:0005262; GO:0005886; GO:0005887; GO:0005892; GO:0007204; GO:0007271; GO:0015276; GO:0022848; GO:0030054; GO:0042166; GO:0042472; GO:0045211; GO:0050910 0 0 0 PF02931;PF02932; O70277 CHOYP_BRAFLDRAFT_87338.6.7 m.44977 sp TRIM3_RAT 26.667 135 88 4 63 191 614 743 9.79E-08 55.1 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P0CB49 CHOYP_YLPM1.2.2 m.24415 sp YLPM1_RAT 59.363 251 99 2 1184 1433 1049 1297 9.79E-88 317 YLPM1_RAT reviewed YLP motif-containing protein 1 (Nuclear protein ZAP3) Ylpm1 Zap Zap3 Rattus norvegicus (Rat) 1376 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0006351; GO:0006355; GO:0016607 0 0 0 0 P17972 CHOYP_KCNC4.1.5 m.10384 sp KCNAW_DROME 31.398 465 280 9 3 444 7 455 9.79E-68 227 KCNAW_DROME reviewed Potassium voltage-gated channel protein Shaw (Shaw2) Shaw SHAW2 CG2822 Drosophila melanogaster (Fruit fly) 498 potassium ion transport [GO:0006813]; protein homooligomerization [GO:0051260]; sleep [GO:0030431] GO:0005249; GO:0005251; GO:0005886; GO:0006813; GO:0008076; GO:0022843; GO:0030431; GO:0051260 0 0 0 PF02214;PF00520; Q1LZ96 CHOYP_LOC100642891.1.1 m.25638 sp ATPF2_BOVIN 52.61 249 117 1 29 276 37 285 9.79E-93 278 ATPF2_BOVIN reviewed ATP synthase mitochondrial F1 complex assembly factor 2 ATPAF2 Bos taurus (Bovine) 289 proton-transporting ATP synthase complex assembly [GO:0043461] GO:0005739; GO:0016607; GO:0043461 0 0 0 PF07542; Q460N5 CHOYP_LOC100636805.1.1 m.45279 sp PAR14_HUMAN 33.333 111 67 3 1171 1275 1042 1151 9.79E-10 67.4 PAR14_HUMAN reviewed Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2) PARP14 BAL2 KIAA1268 Homo sapiens (Human) 1801 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003950; GO:0005634; GO:0005737; GO:0006351; GO:0006355; GO:0016020 0 0 0 PF01661;PF00644; Q5ZIJ0 CHOYP_LOC587806.1.1 m.57504 sp BUD13_CHICK 36.76 574 226 22 4 460 6 559 9.79E-73 242 BUD13_CHICK reviewed BUD13 homolog BUD13 RCJMB04_25m15 Gallus gallus (Chicken) 559 0 0 0 0 0 PF09736; Q6IRN2 CHOYP_HOW.3.5 m.25784 sp QKIB_XENLA 50.543 368 134 7 3 362 5 332 9.79E-113 335 QKIB_XENLA reviewed Protein quaking-B qki-b Xenopus laevis (African clawed frog) 342 cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism development [GO:0007275]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380] GO:0003723; GO:0005634; GO:0005737; GO:0006397; GO:0006417; GO:0007275; GO:0008380; GO:0030154; GO:0051028 0 0 0 PF00013;PF16551;PF16544; Q6P2X9 CHOYP_LOC100883687.1.1 m.23437 sp MOT12_XENTR 28.274 481 290 12 10 483 12 444 9.79E-54 191 MOT12_XENTR reviewed Monocarboxylate transporter 12 (MCT 12) (Solute carrier family 16 member 12) slc16a12 TGas051g14.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 473 creatine transmembrane transport [GO:1902598]; plasma membrane lactate transport [GO:0035879] GO:0005308; GO:0005887; GO:0015129; GO:0015293; GO:0035879; GO:1902598 0 0 cd06174; PF07690; Q6R7D2 CHOYP_Y097.1.1 m.30728 sp Y097_OSHVF 100 181 0 0 1 181 1 181 9.79E-134 374 Y097_OSHVF reviewed Putative RING finger protein ORF97 ORF97 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 181 0 GO:0008270 0 0 0 0 Q803C9 CHOYP_PTDSS1.1.1 m.37764 sp PTSS1_DANRE 56.738 423 175 3 5 420 12 433 9.79E-175 501 PTSS1_DANRE reviewed Phosphatidylserine synthase 1 (PSS-1) (PtdSer synthase 1) (EC 2.7.8.29) (Serine-exchange enzyme I) ptdss1 si:ch211-269k10 zgc:55906 Danio rerio (Zebrafish) (Brachydanio rerio) 465 phosphatidylserine biosynthetic process [GO:0006659]; phospholipid biosynthetic process [GO:0008654] GO:0005789; GO:0006659; GO:0008654; GO:0016021; GO:0016740 PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis. 0 0 PF03034; Q8BXX9 CHOYP_LOC100375592.3.6 m.37692 sp CC169_MOUSE 35.455 110 61 4 1 108 111 212 9.79E-12 62 CC169_MOUSE reviewed Coiled-coil domain-containing protein 169 Ccdc169 Mus musculus (Mouse) 214 0 0 0 0 0 PF15372; Q8YTC2 CHOYP_LOC100891656.1.1 m.62466 sp Y2800_NOSS1 23.188 276 183 9 43 316 729 977 9.79E-11 66.6 Y2800_NOSS1 reviewed Uncharacterized WD repeat-containing protein alr2800 alr2800 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 1258 0 GO:0043531 0 0 0 PF00931;PF00400; Q9V4N3 CHOYP_LOC575345.1.2 m.57209 sp CYB5_DROME 45.349 86 47 0 63 148 3 88 9.79E-21 85.1 CYB5_DROME reviewed Cytochrome b5 (CYTB5) Cyt-b5 CG2140 Drosophila melanogaster (Fruit fly) 134 oxidation-reduction process [GO:0055114]; regulation of hemocyte differentiation [GO:0045610]; regulation of hemocyte proliferation [GO:0035206] GO:0005789; GO:0005811; GO:0012505; GO:0016021; GO:0020037; GO:0031090; GO:0035206; GO:0045610; GO:0046872; GO:0055114 0 0 0 PF00173; P16157 CHOYP_AFUA_1G01020.6.50 m.17938 sp ANK1_HUMAN 35.759 316 189 1 2 303 177 492 9.80E-46 169 ANK1_HUMAN reviewed Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) ANK1 ANK Homo sapiens (Human) 1881 cytoskeleton organization [GO:0007010]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; positive regulation of organelle organization [GO:0010638]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005198; GO:0005200; GO:0005634; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006887; GO:0006888; GO:0007010; GO:0007165; GO:0008093; GO:0010638; GO:0014731; GO:0016323; GO:0016529; GO:0019899; GO:0030018; GO:0030507; GO:0030673; GO:0031430; GO:0042383; GO:0045199; GO:0045211; GO:0051117; GO:0072661 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q5RE52 CHOYP_BRAFLDRAFT_100007.1.1 m.10810 sp APC5_PONAB 35.279 771 449 13 9 766 6 739 9.80E-130 424 APC5_PONAB reviewed Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5) ANAPC5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 755 cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; protein K11-linked ubiquitination [GO:0070979] GO:0005680; GO:0007067; GO:0051301; GO:0070979 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF12862; Q60980 CHOYP_LOC660309.1.2 m.28309 sp KLF3_MOUSE 82.418 91 16 0 304 394 251 341 9.80E-53 182 KLF3_MOUSE reviewed Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2) Klf3 Bklf Mus musculus (Mouse) 344 "cellular response to peptide [GO:1901653]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0005634; GO:0006351; GO:0006355; GO:0046872; GO:1901653 0 0 0 PF00096; Q8NC51 CHOYP_BRAFLDRAFT_60200.1.3 m.22202 sp PAIRB_HUMAN 33.921 227 113 6 5 198 9 231 9.80E-12 66.6 PAIRB_HUMAN reviewed Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1) SERBP1 PAIRBP1 CGI-55 Homo sapiens (Human) 408 regulation of apoptotic process [GO:0042981]; regulation of mRNA stability [GO:0043488] GO:0003730; GO:0005634; GO:0005737; GO:0005886; GO:0005913; GO:0016020; GO:0042981; GO:0043488; GO:0044822; GO:0048471; GO:0070062; GO:0098641 0 0 0 PF04774;PF16174; Q96FC7 CHOYP_contig_056151 m.66707 sp PHIPL_HUMAN 32.719 217 133 5 36 248 165 372 9.80E-27 109 PHIPL_HUMAN reviewed Phytanoyl-CoA hydroxylase-interacting protein-like PHYHIPL KIAA1796 UNQ6309/PRO20934 Homo sapiens (Human) 376 0 GO:0005737; GO:0005739 0 0 0 PF00041; P02556 CHOYP_LOC373275.7.7 m.63850 sp TBB_LYTPI 97.059 102 3 0 3 104 60 161 9.81E-72 214 TBB_LYTPI reviewed Tubulin beta chain (Beta-tubulin) (Fragment) 0 Lytechinus pictus (Painted sea urchin) 177 microtubule-based process [GO:0007017] GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017 0 0 0 PF03953; P86854 CHOYP_LOC764768.1.2 m.3444 sp PLCL_MYTGA 30 150 92 4 14 160 9 148 9.81E-18 79 PLCL_MYTGA reviewed Perlucin-like protein 0 Mytilus galloprovincialis (Mediterranean mussel) 156 0 GO:0005576; GO:0030246 0 0 0 PF00059; Q06852 CHOYP_SLAP1.2.2 m.48270 sp SLAP1_CLOTH 46.862 239 67 24 76 275 1478 1695 9.81E-06 51.6 SLAP1_CLOTH reviewed Cell surface glycoprotein 1 (Outer layer protein B) (S-layer protein 1) olpB Cthe_3078 Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) 2313 polysaccharide catabolic process [GO:0000272] GO:0000272; GO:0005576; GO:0005618; GO:0030115; GO:0030246 0 0 0 PF00963;PF00395; Q15386 CHOYP_LOC100374388.1.2 m.1460 sp UBE3C_HUMAN 49.466 281 129 6 1 275 471 744 9.81E-75 250 UBE3C_HUMAN reviewed Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (HectH2) UBE3C KIAA0010 KIAA10 Homo sapiens (Human) 1083 protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0000502; GO:0004842; GO:0005622; GO:0005634; GO:0005737; GO:0016874; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00632; Q24547 CHOYP_SYX1A.1.1 m.54982 sp STX1A_DROME 30.62 258 166 4 37 290 30 278 9.81E-28 112 STX1A_DROME reviewed Syntaxin-1A (dSynt1) Syx1A syx-1A CG31136 Drosophila melanogaster (Fruit fly) 291 cellularization [GO:0007349]; haltere development [GO:0007482]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; neuromuscular synaptic transmission [GO:0007274]; neurotransmitter secretion [GO:0007269]; regulation of exocytosis [GO:0017157]; regulation of pole plasm oskar mRNA localization [GO:0007317]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle-mediated transport [GO:0016192] GO:0000149; GO:0000281; GO:0005484; GO:0005886; GO:0006886; GO:0006906; GO:0007269; GO:0007274; GO:0007317; GO:0007349; GO:0007482; GO:0008021; GO:0016021; GO:0016081; GO:0016192; GO:0017157; GO:0031201; GO:0031629; GO:0043195; GO:0048278 0 0 0 PF05739;PF00804; Q5PPZ9 CHOYP_GDS1B.1.1 m.52257 sp GDS1B_XENLA 37.755 588 355 5 18 603 19 597 9.81E-125 384 GDS1B_XENLA reviewed Rap1 GTPase-GDP dissociation stimulator 1-B (Rap1gds1-B protein) (RalB-binding protein B) (XsmgGDS-B) (smgGDS-B) rap1gds1-b Xenopus laevis (African clawed frog) 607 positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264] GO:0005096; GO:0005737; GO:0005856; GO:0007264; GO:0017160; GO:0043547 0 0 0 PF00514; Q6ZRF8 CHOYP_LOC100370588.18.19 m.61907 sp RN207_HUMAN 20.979 286 198 9 23 297 103 371 9.81E-11 68.2 RN207_HUMAN reviewed RING finger protein 207 RNF207 C1orf188 Homo sapiens (Human) 634 cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207] GO:0008270; GO:0010628; GO:0030544; GO:0044325; GO:0048471; GO:0051087; GO:0055117; GO:0086019; GO:1901207; GO:1902261; GO:1903762; GO:1903954 0 0 0 PF00643;PF00097; Q7TNC8 CHOYP_GLRA4.1.1 m.36943 sp GLRA2_MOUSE 41.769 407 199 7 13 383 37 441 9.81E-110 332 GLRA2_MOUSE reviewed Glycine receptor subunit alpha-2 Glra2 Mus musculus (Mouse) 452 "cellular response to amino acid stimulus [GO:0071230]; cellular response to ethanol [GO:0071361]; cellular response to zinc ion [GO:0071294]; chloride transmembrane transport [GO:1902476]; ion transmembrane transport [GO:0034220]; neuropeptide signaling pathway [GO:0007218]; response to amino acid [GO:0043200]; spinal cord development [GO:0021510]; synapse assembly [GO:0007416]; synaptic transmission, glycinergic [GO:0060012]" GO:0005887; GO:0007218; GO:0007416; GO:0016594; GO:0016934; GO:0021510; GO:0022852; GO:0030054; GO:0034220; GO:0034707; GO:0042995; GO:0043200; GO:0045211; GO:0046872; GO:0060012; GO:0071230; GO:0071294; GO:0071361; GO:1902476 0 0 0 PF02931;PF02932; Q80XI3 CHOYP_NEMVEDRAFT_V1G217091.1.4 m.12639 sp IF4G3_MOUSE 63.265 98 36 0 412 509 719 816 9.81E-30 127 IF4G3_MOUSE reviewed Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) Eif4g3 Mus musculus (Mouse) 1579 positive regulation of meiosis I [GO:0060903]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of translation [GO:0045727]; spermatogenesis [GO:0007283] GO:0001934; GO:0003743; GO:0007283; GO:0044822; GO:0045727; GO:0060903 0 0 0 PF02847;PF02854;PF02020; Q868Z9 CHOYP_LOC100117523.1.1 m.41517 sp PPN_DROME 33.529 683 305 17 755 1317 1490 2143 9.81E-99 360 PPN_DROME reviewed Papilin Ppn CG33103 Drosophila melanogaster (Fruit fly) 2898 extracellular matrix organization [GO:0030198]; multicellular organism development [GO:0007275] GO:0004222; GO:0004867; GO:0005201; GO:0005604; GO:0007275; GO:0008270; GO:0030198 0 0 0 PF05986;PF07679;PF00014;PF08686;PF00090; Q8NHV1 CHOYP_LOC101326262.1.1 m.60999 sp GIMA7_HUMAN 30.208 192 103 5 213 373 7 198 9.81E-14 74.3 GIMA7_HUMAN reviewed GTPase IMAP family member 7 (Immunity-associated nucleotide 7 protein) (IAN-7) GIMAP7 IAN7 Homo sapiens (Human) 300 0 GO:0003924; GO:0005525; GO:0005737; GO:0005811; GO:0042803 0 0 0 PF04548; Q9NBX4 CHOYP_SS1G_11766.1.1 m.66384 sp RTXE_DROME 23.929 397 255 13 187 555 309 686 9.81E-24 109 RTXE_DROME reviewed Probable RNA-directed DNA polymerase from transposon X-element (EC 2.7.7.49) (Reverse transcriptase) X-element\ORF2 ORF2 Drosophila melanogaster (Fruit fly) 908 "transposition, DNA-mediated [GO:0006313]" GO:0003964; GO:0006313 0 0 0 PF14529;PF00078; Q9UQ03 CHOYP_LOC100122439.1.1 m.8647 sp COR2B_HUMAN 52.439 410 192 1 6 415 11 417 9.81E-162 474 COR2B_HUMAN reviewed Coronin-2B (Coronin-like protein C) (Clipin-C) (Protein FC96) CORO2B KIAA0925 Homo sapiens (Human) 480 actin cytoskeleton organization [GO:0030036] GO:0003779; GO:0005737; GO:0015629; GO:0016020; GO:0030036; GO:0051015 0 0 0 PF08953;PF00400; Q9WVG9 CHOYP_MS3L1.1.1 m.8778 sp MS3L1_MOUSE 33.333 579 290 17 2 556 3 509 9.81E-78 257 MS3L1_MOUSE reviewed Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1) Msl3 Msl31 Msl3l1 Mus musculus (Mouse) 525 "chromatin modification [GO:0016568]; chromatin remodeling [GO:0006338]; chromatin silencing [GO:0006342]; histone deacetylation [GO:0016575]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; histone H4-K16 acetylation [GO:0043984]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0006338; GO:0006342; GO:0006351; GO:0016568; GO:0016575; GO:0035064; GO:0035267; GO:0043967; GO:0043968; GO:0043984; GO:0072487 0 0 0 PF05712;PF11717; A5DVD6 CHOYP_BRAFLDRAFT_118811.1.1 m.54193 sp PAN1_LODEL 40.299 67 30 1 32 98 219 275 9.82E-06 48.9 PAN1_LODEL reviewed Actin cytoskeleton-regulatory complex protein PAN1 PAN1 LELG_01322 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) 1505 endocytosis [GO:0006897] GO:0005509; GO:0005886; GO:0006897; GO:0010008; GO:0030479 0 0 0 PF08226;PF12763;PF02205; P09815 CHOYP_contig_042092 m.48359 sp ICEN_PSEFL 35.331 317 182 5 11 306 410 724 9.82E-15 78.2 ICEN_PSEFL reviewed Ice nucleation protein inaW Pseudomonas fluorescens 1210 0 GO:0009279; GO:0050825 0 0 0 PF00818; P14373 CHOYP_LOC100374741.66.83 m.53336 sp TRI27_HUMAN 29.688 192 101 8 25 196 96 273 9.82E-08 57 TRI27_HUMAN reviewed Zinc finger protein RFP (EC 6.3.2.-) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27) TRIM27 RFP RNF76 Homo sapiens (Human) 513 "Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell proliferation [GO:0008283]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; negative regulation of adaptive immune response [GO:0002820]; negative regulation of calcium ion import [GO:0090281]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of interleukin-2 secretion [GO:1900041]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of actin nucleation [GO:0051127]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; retrograde transport, endosome to Golgi [GO:0042147]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]" GO:0000122; GO:0002820; GO:0003676; GO:0003677; GO:0004714; GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0005768; GO:0005769; GO:0005829; GO:0005887; GO:0006351; GO:0006469; GO:0007283; GO:0008270; GO:0008283; GO:0016020; GO:0016605; GO:0016874; GO:0031965; GO:0032720; GO:0032897; GO:0034314; GO:0042147; GO:0042802; GO:0045087; GO:0045814; GO:0046872; GO:0051091; GO:0051127; GO:0070206; GO:0070534; GO:0072643; GO:0090281; GO:1900041; GO:1902187 0 0 0 PF13765;PF00622;PF00643; P20273 CHOYP_LOC100880815.7.7 m.63371 sp CD22_HUMAN 26.205 477 286 23 125 574 257 694 9.82E-24 111 CD22_HUMAN reviewed B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) CD22 SIGLEC2 Homo sapiens (Human) 847 cell adhesion [GO:0007155] GO:0005886; GO:0007155; GO:0016021; GO:0030246; GO:0070062 0 0 0 PF08205;PF13895; P44836 CHOYP_NEMVEDRAFT_V1G107265.1.1 m.23362 sp HGP3_HAEIN 34.409 93 55 1 127 213 3 95 9.82E-11 65.5 HGP3_HAEIN reviewed Probable hemoglobin and hemoglobin-haptoglobin-binding protein 3 HI_0712 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 1084 0 GO:0004872; GO:0009279; GO:0015344; GO:0016021 0 0 0 PF07715;PF04886;PF00593; P49165 CHOYP_RL4.4.6 m.37115 sp RL4_URECA 77.67 103 23 0 1 103 1 103 9.82E-52 171 RL4_URECA reviewed 60S ribosomal protein L4 (L1) RPL4 RPL1 Urechis caupo (Innkeeper worm) (Spoonworm) 386 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF14374;PF00573; Q4PMB3 CHOYP_RS4.6.11 m.38361 sp RS4_IXOSC 79.151 259 54 0 4 262 3 261 9.82E-154 431 RS4_IXOSC reviewed 40S ribosomal protein S4 RpS4 Ixodes scapularis (Black-legged tick) (Deer tick) 262 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412; GO:0019843 0 0 0 PF16121;PF00467;PF00900;PF08071;PF01479; Q5M8Z0 CHOYP_BRAFLDRAFT_90098.1.4 m.3841 sp BHMT1_XENTR 33.236 343 193 8 4 330 8 330 9.82E-48 169 BHMT1_XENTR reviewed Betaine--homocysteine S-methyltransferase 1 (EC 2.1.1.5) bhmt Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 403 amino-acid betaine catabolic process [GO:0006579]; methionine biosynthetic process [GO:0009086] GO:0005829; GO:0006579; GO:0008270; GO:0008898; GO:0009086; GO:0047150 PATHWAY: Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.; PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. 0 0 PF02574; Q8NE09 CHOYP_LOC752884.1.1 m.4412 sp RGS22_HUMAN 36.458 96 55 1 444 539 1045 1134 9.82E-13 75.5 RGS22_HUMAN reviewed Regulator of G-protein signaling 22 (RGS22) RGS22 Homo sapiens (Human) 1264 negative regulation of signal transduction [GO:0009968] GO:0005096; GO:0005634; GO:0005737; GO:0005886; GO:0009968 0 0 0 PF00615; Q9UMZ3 CHOYP_BRAFLDRAFT_124749.2.3 m.46236 sp PTPRQ_HUMAN 25 440 276 16 284 691 58 475 9.82E-10 66.2 PTPRQ_HUMAN reviewed Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48) PTPRQ Homo sapiens (Human) 2332 cell differentiation [GO:0030154]; inner ear morphogenesis [GO:0042472]; phosphatidylinositol dephosphorylation [GO:0046856]; regulation of fat cell differentiation [GO:0045598] GO:0004725; GO:0016021; GO:0030154; GO:0042472; GO:0045598; GO:0046856 0 0 0 PF00041;PF00102; A0A0R4IBK5 CHOYP_BRAFLDRAFT_106560.10.14 m.46985 sp R213A_DANRE 28.59 1532 865 54 1856 3216 1872 3345 9.83E-123 442 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 P02707 CHOYP_CLEC10A.2.3 m.16239 sp LECH_CHICK 25.625 160 112 4 42 199 49 203 9.83E-09 56.2 LECH_CHICK reviewed Hepatic lectin 0 Gallus gallus (Chicken) 207 endocytosis [GO:0006897] GO:0006897; GO:0016021; GO:0030246 0 0 0 PF00059; Q0IHI6 CHOYP_NDKB.1.1 m.24474 sp MED30_XENLA 35.802 162 93 5 29 184 27 183 9.83E-27 103 MED30_XENLA reviewed Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) med30 Xenopus laevis (African clawed frog) 184 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355 0 0 0 PF11315; Q0V9J5 CHOYP_EIF1A.1.1 m.30304 sp EIF1A_XENTR 56.115 139 55 1 1 133 1 139 9.83E-49 158 EIF1A_XENTR reviewed Probable RNA-binding protein EIF1AD (Eukaryotic translation initiation factor 1A domain-containing protein) eif1ad Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 179 0 GO:0003743; GO:0005634 0 0 0 PF01176; Q499U1 CHOYP_LOC100544135.1.2 m.43774 sp S2538_RAT 46.392 97 52 0 3 99 39 135 9.83E-21 87.4 S2538_RAT reviewed Solute carrier family 25 member 38 Slc25a38 Rattus norvegicus (Rat) 326 erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; translation [GO:0006412]; transmembrane transport [GO:0055085] GO:0003735; GO:0005215; GO:0005743; GO:0006412; GO:0006783; GO:0016021; GO:0030218; GO:0055085 0 0 0 PF00153; Q49YE0 CHOYP_SMP_043120.1.1 m.12494 sp Y1056_STAS1 32.051 156 82 5 3 149 5 145 9.83E-12 62.4 Y1056_STAS1 reviewed Putative universal stress protein SSP1056 SSP1056 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229) 167 response to stress [GO:0006950] GO:0005737; GO:0006950 0 0 0 PF00582; Q5ZLT7 CHOYP_BRAFLDRAFT_120788.1.1 m.48465 sp BZW1_CHICK 53.815 249 107 2 31 277 1 243 9.83E-95 288 BZW1_CHICK reviewed Basic leucine zipper and W2 domain-containing protein 1 BZW1 RCJMB04_4o16 Gallus gallus (Chicken) 418 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005737; GO:0006351; GO:0006355; GO:0016020; GO:0044822 0 0 0 PF02020; Q6V595 CHOYP_KLH12.2.3 m.14483 sp KLHL6_MOUSE 23.486 545 362 17 16 533 56 572 9.83E-22 103 KLHL6_MOUSE reviewed Kelch-like protein 6 Klhl6 Mus musculus (Mouse) 619 B cell receptor signaling pathway [GO:0050853]; germinal center formation [GO:0002467] GO:0002467; GO:0050853 0 0 0 PF07707;PF00651;PF01344; Q99LJ2 CHOYP_BRAFLDRAFT_276832.2.2 m.63339 sp ABTB1_MOUSE 52.092 478 225 3 1 475 1 477 9.83E-179 512 ABTB1_MOUSE reviewed Ankyrin repeat and BTB/POZ domain-containing protein 1 Abtb1 Bpoz Mus musculus (Mouse) 478 0 GO:0003746; GO:0005730; GO:0005737; GO:0005886 0 0 0 PF12796;PF00651; C5FSQ7 CHOYP_RCF1.2.2 m.63733 sp RCF1_ARTOC 28.155 103 74 0 44 146 3 105 9.84E-10 58.2 RCF1_ARTOC reviewed "Respiratory supercomplex factor 1, mitochondrial" RCF1 AIM31 MCYG_05729 Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis) 187 mitochondrial respiratory chain complex IV assembly [GO:0033617]; mitochondrial respiratory chain supercomplex assembly [GO:0097250] GO:0031305; GO:0033617; GO:0097249; GO:0097250 0 0 0 PF04588; O70277 CHOYP_BRAFLDRAFT_99973.1.8 m.3237 sp TRIM3_RAT 26.667 120 83 3 57 172 625 743 9.84E-06 48.9 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P22488 CHOYP_LOC100533447.1.3 m.37261 sp IFEA_HELAS 38.476 538 318 5 120 655 44 570 9.84E-112 350 IFEA_HELAS reviewed Non-neuronal cytoplasmic intermediate filament protein (IF) 0 Helix aspersa (Brown garden snail) (Cornu aspersum) 576 0 GO:0005198; GO:0005737; GO:0005882 0 0 0 PF00038; Q4FZY0 CHOYP_LOC100375509.1.1 m.48842 sp EFHD2_RAT 58.278 151 62 1 2 152 50 199 9.84E-53 171 EFHD2_RAT reviewed EF-hand domain-containing protein D2 (Swiprosin-1) Efhd2 Sws1 Rattus norvegicus (Rat) 239 0 GO:0005509; GO:0045121 0 0 0 PF13499; Q68FR8 CHOYP_LOC100366892.3.3 m.66687 sp TBA3_RAT 90.099 101 9 1 1 100 261 361 9.84E-61 196 TBA3_RAT reviewed Tubulin alpha-3 chain (Alpha-tubulin 3) [Cleaved into: Detyrosinated tubulin alpha-3 chain] Tuba3a Tuba3; Tuba3b Tuba3 Rattus norvegicus (Rat) 450 microtubule-based process [GO:0007017] GO:0003924; GO:0005200; GO:0005525; GO:0005737; GO:0005874; GO:0007017; GO:0036064 0 0 0 PF00091;PF03953; Q7TPV2 CHOYP_NEMVEDRAFT_V1G218444.2.2 m.36975 sp DZIP3_MOUSE 23.81 147 103 2 22 160 394 539 9.84E-09 59.3 DZIP3_MOUSE reviewed E3 ubiquitin-protein ligase DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog) Dzip3 Kiaa0675 Mus musculus (Mouse) 1204 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0000209; GO:0003723; GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0019902; GO:0031593; GO:0042787; GO:0043161; GO:0044822; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF13639; Q8CFD5 CHOYP_ERCC8.1.1 m.14283 sp ERCC8_MOUSE 53.218 404 180 2 1 404 1 395 9.84E-156 447 ERCC8_MOUSE reviewed DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat protein CSA homolog) Ercc8 Ckn1 Csa Mus musculus (Mouse) 397 cellular response to DNA damage stimulus [GO:0006974]; nucleotide-excision repair [GO:0006289]; positive regulation of DNA repair [GO:0045739]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; response to oxidative stress [GO:0006979]; response to UV [GO:0009411]; response to X-ray [GO:0010165]; transcription-coupled nucleotide-excision repair [GO:0006283] GO:0000109; GO:0000209; GO:0004842; GO:0005634; GO:0006283; GO:0006289; GO:0006974; GO:0006979; GO:0009411; GO:0010165; GO:0016363; GO:0031464; GO:0032403; GO:0043161; GO:0043234; GO:0045739; GO:0051865 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00400; Q8IWQ3 CHOYP_BRAFLDRAFT_87940.1.1 m.56429 sp BRSK2_HUMAN 48.696 345 117 9 4 290 292 634 9.84E-91 290 BRSK2_HUMAN reviewed Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) BRSK2 C11orf7 PEN11B SADA STK29 HUSSY-12 Homo sapiens (Human) 736 "actin cytoskeleton reorganization [GO:0031532]; axonogenesis [GO:0007409]; cell division [GO:0051301]; ERAD pathway [GO:0036503]; establishment of cell polarity [GO:0030010]; exocytosis [GO:0006887]; G2/M transition of mitotic cell cycle [GO:0000086]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; mitotic nuclear division [GO:0007067]; neuron differentiation [GO:0030182]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of ATPase activity [GO:0043462]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of retrograde protein transport, ER to cytosol [GO:1904152]" GO:0000086; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005813; GO:0006468; GO:0006887; GO:0007067; GO:0007409; GO:0018105; GO:0030010; GO:0030182; GO:0031532; GO:0036503; GO:0043462; GO:0048471; GO:0050321; GO:0051117; GO:0051301; GO:0060590; GO:0061178; GO:0070059; GO:1904152 0 0 0 PF00069; Q8K3K9 CHOYP_GIMA4.7.7 m.56169 sp GIMA4_RAT 29.814 161 102 5 34 184 78 237 9.84E-14 73.6 GIMA4_RAT reviewed GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (Immunity-associated protein 4) Gimap4 Ian1 Imap4 Rattus norvegicus (Rat) 310 0 GO:0005525; GO:0005829 0 0 0 PF04548; Q9C040 CHOYP_BRAFLDRAFT_77833.1.1 m.34094 sp TRIM2_HUMAN 25.651 269 166 15 306 558 492 742 9.84E-09 62 TRIM2_HUMAN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) TRIM2 KIAA0517 RNF86 Homo sapiens (Human) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9HAV5 CHOYP_TNR27.3.3 m.63677 sp TNR27_HUMAN 36.364 88 48 3 31 118 6 85 9.84E-06 50.4 TNR27_HUMAN reviewed Tumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor) EDA2R TNFRSF27 XEDAR UNQ2448/PRO5727/PRO34080 Homo sapiens (Human) 297 ectodermal cell differentiation [GO:0010668]; epidermis development [GO:0008544]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; multicellular organism development [GO:0007275]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; tissue development [GO:0009888]; tumor necrosis factor-mediated signaling pathway [GO:0033209] GO:0004872; GO:0005031; GO:0005622; GO:0005886; GO:0005887; GO:0007275; GO:0008544; GO:0009888; GO:0010668; GO:0016021; GO:0033209; GO:0043123; GO:0046330; GO:0051092; GO:0072332 0 0 0 PF00020; Q9UGM3 CHOYP_LOC754303.1.1 m.60124 sp DMBT1_HUMAN 42.557 524 245 10 243 738 494 989 9.84E-102 349 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; Q03145 CHOYP_ZAP70.1.1 m.50764 sp EPHA2_MOUSE 34.448 299 182 7 248 541 616 905 9.85E-49 187 EPHA2_MOUSE reviewed Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2) Epha2 Eck Myk2 Sek2 Mus musculus (Mouse) 977 activation of GTPase activity [GO:0090630]; axial mesoderm formation [GO:0048320]; blood vessel development [GO:0001568]; blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:0002043]; blood vessel morphogenesis [GO:0048514]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; defense response to Gram-positive bacterium [GO:0050830]; ephrin receptor signaling pathway [GO:0048013]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; keratinocyte differentiation [GO:0030216]; lens fiber cell morphogenesis [GO:0070309]; mammary gland epithelial cell proliferation [GO:0033598]; negative regulation of angiogenesis [GO:0016525]; negative regulation of chemokine production [GO:0032682]; negative regulation of cytokine production [GO:0001818]; negative regulation of lymphangiogenesis [GO:1901491]; negative regulation of protein kinase B signaling [GO:0051898]; neural tube development [GO:0021915]; neuron differentiation [GO:0030182]; notochord cell development [GO:0060035]; notochord formation [GO:0014028]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; osteoclast differentiation [GO:0030316]; pericyte cell differentiation [GO:1904238]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; post-anal tail morphogenesis [GO:0036342]; protein kinase B signaling [GO:0043491]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of lamellipodium assembly [GO:0010591]; response to growth factor [GO:0070848]; skeletal system development [GO:0001501]; vasculogenesis [GO:0001570] GO:0001501; GO:0001568; GO:0001570; GO:0001649; GO:0001818; GO:0002043; GO:0004714; GO:0005003; GO:0005524; GO:0005622; GO:0005886; GO:0005887; GO:0005925; GO:0006954; GO:0007155; GO:0008630; GO:0009986; GO:0010591; GO:0014028; GO:0016477; GO:0016525; GO:0021915; GO:0030182; GO:0030216; GO:0030316; GO:0031256; GO:0031258; GO:0032587; GO:0032682; GO:0033598; GO:0033628; GO:0036342; GO:0043491; GO:0043535; GO:0045765; GO:0046849; GO:0048013; GO:0048320; GO:0048514; GO:0048570; GO:0050830; GO:0051898; GO:0060035; GO:0060326; GO:0060444; GO:0070309; GO:0070372; GO:0070848; GO:0090004; GO:0090630; GO:1901491; GO:1904238 0 0 0 PF14575;PF01404;PF00041;PF07714;PF00536; Q6GR16 CHOYP_PHUM_PHUM617090.1.1 m.66271 sp EPABB_XENLA 57.534 146 58 1 39 180 475 620 9.85E-42 151 EPABB_XENLA reviewed Embryonic polyadenylate-binding protein B (Embryonic poly(A)-binding protein B) (ePAB-B) (ePABP-B) (XePABP-B) epabp-b Xenopus laevis (African clawed frog) 629 chordate embryonic development [GO:0043009]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; translation [GO:0006412] GO:0000166; GO:0005737; GO:0006397; GO:0006412; GO:0008143; GO:0031370; GO:0043009; GO:0043621; GO:0048255; GO:0060212 0 0 0 PF00658;PF00076; Q8BW94 CHOYP_BRAFLDRAFT_118158.1.1 m.37728 sp DYH3_MOUSE 71.963 107 29 1 1 107 3532 3637 9.85E-48 166 DYH3_MOUSE reviewed "Dynein heavy chain 3, axonemal (Axonemal beta dynein heavy chain 3) (Ciliary dynein heavy chain 3)" Dnah3 Dnahc3 Mus musculus (Mouse) 4083 microtubule-based movement [GO:0007018] GO:0003777; GO:0005524; GO:0005737; GO:0005874; GO:0007018; GO:0036156 0 0 0 PF12780;PF08393;PF03028;PF12777; Q8C6L5 CHOYP_CGAS.5.6 m.47044 sp CGAS_MOUSE 34.568 81 51 1 2 80 400 480 9.85E-07 53.9 CGAS_MOUSE reviewed Cyclic GMP-AMP synthase (cGAMP synthase) (cGAS) (m-cGAS) (EC 2.7.7.86) (2'3'-cGAMP synthase) (Mab-21 domain-containing protein 1) Mb21d1 Mus musculus (Mouse) 507 activation of innate immune response [GO:0002218]; cellular response to exogenous dsRNA [GO:0071360]; cyclic nucleotide biosynthetic process [GO:0009190]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of defense response to virus by host [GO:0002230] GO:0002218; GO:0002230; GO:0003677; GO:0005524; GO:0005525; GO:0005829; GO:0009190; GO:0045087; GO:0046872; GO:0051607; GO:0061501; GO:0071360 0 0 0 PF03281; Q8K1P8 CHOYP_LOC100903112.1.1 m.1619 sp MOT8_RAT 23.684 456 325 11 61 508 81 521 9.85E-29 124 MOT8_RAT reviewed Monocarboxylate transporter 8 (MCT 8) (Solute carrier family 16 member 2) SLC16A2 Mct8 Rattus norvegicus (Rat) 545 hormone transport [GO:0009914]; ion transmembrane transport [GO:0034220]; thyroid hormone transport [GO:0070327] GO:0005887; GO:0009914; GO:0015293; GO:0015349; GO:0016021; GO:0034220; GO:0070327 0 0 cd06174; PF07690; Q9CR40 CHOYP_NEMVEDRAFT_V1G120526.3.5 m.12361 sp KLH28_MOUSE 28.369 141 96 4 10 147 14 152 9.85E-08 58.9 KLH28_MOUSE reviewed Kelch-like protein 28 (BTB/POZ domain-containing protein 5) Klhl28 Btbd5 Mus musculus (Mouse) 571 protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0031463; GO:0042787 0 0 0 PF07707;PF00651;PF01344; Q9D903 CHOYP_EBNA1BP2.1.1 m.63216 sp EBP2_MOUSE 50.658 304 131 6 3 293 6 303 9.85E-82 252 EBP2_MOUSE reviewed Probable rRNA-processing protein EBP2 Ebna1bp2 Ebp2 Mus musculus (Mouse) 306 ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364] GO:0005634; GO:0005730; GO:0006364; GO:0030687; GO:0034399; GO:0042273; GO:0044822 0 0 0 PF05890; Q9DFS4 CHOYP_STARD3.1.1 m.35610 sp STAR3_DANRE 34.856 416 242 9 70 476 48 443 9.85E-74 242 STAR3_DANRE reviewed StAR-related lipid transfer protein 3 (MLN64-like protein) (START domain-containing protein 3) (StARD3) stard3 mln64 Danio rerio (Zebrafish) (Brachydanio rerio) 448 lipid transport [GO:0006869]; steroid biosynthetic process [GO:0006694] GO:0006694; GO:0006869; GO:0008289 0 0 0 PF10457;PF01852; Q9LTD8 CHOYP_LOC100379052.2.2 m.25150 sp Y5279_ARATH 44.5 400 174 5 47 411 13 399 9.85E-106 327 Y5279_ARATH reviewed DUF21 domain-containing protein At5g52790 (CBS domain-containing protein CBSDUF5) CBSDUF5 At5g52790 F6N7.28 Arabidopsis thaliana (Mouse-ear cress) 500 0 GO:0016021 0 0 0 PF01595; E1BD59 CHOYP_BRAFLDRAFT_117133.1.2 m.2007 sp TRI56_BOVIN 21.875 288 186 10 18 279 20 294 9.86E-11 67.4 TRI56_BOVIN reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) TRIM56 Bos taurus (Bovine) 732 defense response to virus [GO:0051607]; interferon-beta production [GO:0032608]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0051607; GO:0070534 0 0 0 PF00643;PF13445; O14974 CHOYP_LOC100114433.2.4 m.6343 sp MYPT1_HUMAN 60.49 286 113 0 22 307 2 287 9.86E-116 385 MYPT1_HUMAN reviewed Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) PPP1R12A MBS MYPT1 Homo sapiens (Human) 1030 cellular response to drug [GO:0035690]; centrosome organization [GO:0051297]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic nuclear division [GO:0007067]; negative regulation of catalytic activity [GO:0043086]; positive regulation of myosin-light-chain-phosphatase activity [GO:0035508]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of myosin-light-chain-phosphatase activity [GO:0035507]; regulation of nucleocytoplasmic transport [GO:0046822] GO:0000086; GO:0000776; GO:0004721; GO:0004857; GO:0004871; GO:0005654; GO:0005737; GO:0005813; GO:0005829; GO:0005925; GO:0006470; GO:0007067; GO:0015629; GO:0019208; GO:0019901; GO:0030018; GO:0030155; GO:0031672; GO:0035507; GO:0035508; GO:0035690; GO:0043086; GO:0043292; GO:0045944; GO:0046822; GO:0051297; GO:0071889; GO:0072357 0 0 0 PF12796;PF15898; O15442 CHOYP_LOC100636083.1.1 m.59778 sp MPPD1_HUMAN 53.516 256 111 4 87 339 73 323 9.86E-92 280 MPPD1_HUMAN reviewed Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) MPPED1 C22orf1 FAM1A Homo sapiens (Human) 326 0 GO:0016787 0 0 0 PF00149; O34371 CHOYP_PHT4.1.1 m.18841 sp YTET_BACSU 25.275 364 233 15 40 386 37 378 9.86E-18 88.2 YTET_BACSU reviewed Putative oxidoreductase YteT (EC 1.-.-.-) yteT BSU30100 Bacillus subtilis (strain 168) 428 oxidation-reduction process [GO:0055114] GO:0016491; GO:0055114 0 0 0 PF01408;PF02894; O70277 CHOYP_LOC101239226.1.1 m.64620 sp TRIM3_RAT 28.09 89 60 1 141 229 622 706 9.86E-06 49.7 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; P09470 CHOYP_ACE.4.4 m.17563 sp ACE_MOUSE 43.172 227 128 1 1 226 807 1033 9.86E-56 205 ACE_MOUSE reviewed "Angiotensin-converting enzyme (ACE) (EC 3.2.1.-) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]" Ace Dcp1 Mus musculus (Mouse) 1312 arachidonic acid secretion [GO:0050482]; beta-amyloid metabolic process [GO:0050435]; cell proliferation in bone marrow [GO:0071838]; heart contraction [GO:0060047]; hormone catabolic process [GO:0042447]; kidney development [GO:0001822]; negative regulation of gap junction assembly [GO:1903597]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; neutrophil mediated immunity [GO:0002446]; peptide catabolic process [GO:0043171]; positive regulation of peptidyl-cysteine S-nitrosylation [GO:2000170]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of protein binding [GO:0032092]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of systemic arterial blood pressure [GO:0003084]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of angiotensin metabolic process [GO:0060177]; regulation of blood pressure [GO:0008217]; regulation of hematopoietic stem cell proliferation [GO:1902033]; regulation of systemic arterial blood pressure by renin-angiotensin [GO:0003081]; spermatogenesis [GO:0007283] GO:0001822; GO:0002446; GO:0003081; GO:0003084; GO:0004175; GO:0004180; GO:0005615; GO:0005737; GO:0005764; GO:0005768; GO:0005886; GO:0007283; GO:0008144; GO:0008217; GO:0008233; GO:0008237; GO:0008238; GO:0008240; GO:0008241; GO:0008270; GO:0009897; GO:0010608; GO:0010629; GO:0016021; GO:0031404; GO:0031434; GO:0031711; GO:0032091; GO:0032092; GO:0042447; GO:0043171; GO:0050435; GO:0050482; GO:0051019; GO:0060047; GO:0060177; GO:0061098; GO:0070062; GO:0070573; GO:0071838; GO:1900086; GO:1902033; GO:1903597; GO:2000170 0 0 0 PF01401; P10982 CHOYP_ACT1.5.7 m.38236 sp ACT1_ABSGL 84.034 119 15 1 3 117 4 122 9.86E-70 209 ACT1_ABSGL reviewed Actin-1 (Fragment) ACT1 Absidia glauca (Pin mould) 140 0 GO:0005524; GO:0005737; GO:0005856 0 0 0 PF00022; Q6PFY8 CHOYP_LOC100375954.1.6 m.23607 sp TRI45_MOUSE 28.358 201 124 5 8 196 129 321 9.86E-14 77.4 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8N2Y8 CHOYP_LOC661485.1.1 m.41852 sp RUSC2_HUMAN 35.955 178 106 3 1361 1536 966 1137 9.86E-24 114 RUSC2_HUMAN reviewed Iporin (Interacting protein of Rab1) (RUN and SH3 domain-containing protein 2) RUSC2 KIAA0375 Homo sapiens (Human) 1516 0 GO:0005829; GO:0017137; GO:0031410; GO:0070062 0 0 0 PF02759;PF07653; Q8N9Z9 CHOYP_LOC100378619.1.2 m.21468 sp LMTD1_HUMAN 32.951 349 191 11 684 1010 49 376 9.86E-43 164 LMTD1_HUMAN reviewed Lamin tail domain-containing protein 1 (Intermediate filament tail domain-containing protein 1) LMNTD1 IFLTD1 Homo sapiens (Human) 388 cell proliferation [GO:0008283] GO:0005198; GO:0005635; GO:0005737; GO:0005882; GO:0008283 0 0 0 PF00932; Q96KE9 CHOYP_BTBD6.3.6 m.20916 sp BTBD6_HUMAN 30.858 431 275 9 9 426 62 482 9.86E-50 178 BTBD6_HUMAN reviewed BTB/POZ domain-containing protein 6 (Lens BTB domain protein) BTBD6 BDPL Homo sapiens (Human) 485 neurogenesis [GO:0022008]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of proteolysis [GO:0030162] GO:0000932; GO:0005829; GO:0019005; GO:0022008; GO:0030162; GO:0031625; GO:0042787; GO:0043161 0 0 0 PF07707;PF00651;PF08005; Q9ESN6 CHOYP_DESOR_1391.1.1 m.53298 sp TRIM2_MOUSE 27.615 239 151 10 135 363 516 742 9.86E-11 66.6 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9ESN6 CHOYP_TRIM2.47.59 m.53277 sp TRIM2_MOUSE 27.586 174 104 5 141 305 535 695 9.86E-09 59.7 TRIM2_MOUSE reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) (Neural activity-related RING finger protein) Trim2 Kiaa0517 Narf Mus musculus (Mouse) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0017022; GO:0043523; GO:0061630 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; Q9NU22 CHOYP_MDN1.2.8 m.1779 sp MDN1_HUMAN 55.161 310 138 1 2 310 656 965 9.86E-116 370 MDN1_HUMAN reviewed Midasin (MIDAS-containing protein) MDN1 KIAA0301 Homo sapiens (Human) 5596 protein complex assembly [GO:0006461]; ribosomal large subunit assembly [GO:0000027] GO:0000027; GO:0005524; GO:0005634; GO:0005730; GO:0005737; GO:0006461; GO:0016020; GO:0016887; GO:0045111; GO:0051082 0 0 0 PF07728; Q9R085 CHOYP_USP15.2.2 m.65099 sp UBP15_RAT 44 225 99 2 6 204 7 230 9.86E-51 189 UBP15_RAT reviewed Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin carboxyl-terminal hydrolase of 109 kDa) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) Usp15 ubp109 Rattus norvegicus (Rat) 952 BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; protein deubiquitination [GO:0016579]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0004197; GO:0004843; GO:0005634; GO:0005737; GO:0006511; GO:0007179; GO:0016579; GO:0030509; GO:0035520; GO:0035616; GO:0060389 0 0 0 PF06337;PF14836;PF00443;PF14533; A0A0R4IBK5 CHOYP_NEMVEDRAFT_V1G244806.2.2 m.52012 sp R213A_DANRE 27.629 1759 1010 67 1403 2984 1828 3500 9.87E-128 459 R213A_DANRE reviewed E3 ubiquitin-protein ligase rnf213-alpha (EC 3.6.4.-) (EC 6.3.2.-) (Mysterin-A) (Mysterin-alpha) (RING finger protein 213-A) (RING finger protein 213-alpha) rnf213a Danio rerio (Zebrafish) (Brachydanio rerio) 5209 sprouting angiogenesis [GO:0002040] GO:0002040; GO:0004842; GO:0005829; GO:0008270; GO:0016874; GO:0016887 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q63HN8}. 0 0 0 O43312 CHOYP_MTSS1.5.5 m.60086 sp MTSS1_HUMAN 61.128 337 119 5 1 332 1 330 9.87E-123 391 MTSS1_HUMAN reviewed Metastasis suppressor protein 1 (Metastasis suppressor YGL-1) (Missing in metastasis protein) MTSS1 KIAA0429 MIM Homo sapiens (Human) 755 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cellular response to fluid shear stress [GO:0071498]; epithelial cell proliferation involved in renal tubule morphogenesis [GO:2001013]; glomerulus morphogenesis [GO:0072102]; microspike assembly [GO:0030035]; movement of cell or subcellular component [GO:0006928]; negative regulation of epithelial cell proliferation [GO:0050680]; nephron tubule epithelial cell differentiation [GO:0072160]; plasma membrane organization [GO:0007009]; positive regulation of defense response to virus by host [GO:0002230]; renal tubule morphogenesis [GO:0061333]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; xenophagy [GO:0098792] GO:0001726; GO:0002230; GO:0003785; GO:0005102; GO:0005737; GO:0006928; GO:0007009; GO:0007155; GO:0007169; GO:0015629; GO:0030035; GO:0030036; GO:0030139; GO:0042802; GO:0050680; GO:0061333; GO:0071498; GO:0072102; GO:0072160; GO:0098792; GO:2001013 0 0 0 PF08397;PF02205; O70277 CHOYP_BRAFLDRAFT_87272.5.6 m.52697 sp TRIM3_RAT 27.273 132 86 4 528 651 614 743 9.87E-07 55.8 TRIM3_RAT reviewed Tripartite motif-containing protein 3 (Brain-expressed RING finger protein) (RING finger protein 22) Trim3 Berp Rnf22 Rattus norvegicus (Rat) 744 protein transport [GO:0015031] GO:0005737; GO:0005769; GO:0008270; GO:0015031 0 0 0 PF00630;PF01436;PF00643;PF13445; O75486 CHOYP_LOC100377560.1.1 m.66612 sp SUPT3_HUMAN 46.591 264 135 4 20 281 97 356 9.87E-75 240 SUPT3_HUMAN reviewed Transcription initiation protein SPT3 homolog (SPT3-like protein) SUPT3H SPT3 Homo sapiens (Human) 399 "histone deubiquitination [GO:0016578]; histone H3 acetylation [GO:0043966]; mitophagy in response to mitochondrial depolarization [GO:0098779]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription from RNA polymerase II promoter [GO:0006366]; xenophagy [GO:0098792]" GO:0000124; GO:0002230; GO:0003677; GO:0003713; GO:0005634; GO:0005654; GO:0006355; GO:0006357; GO:0006366; GO:0016578; GO:0030914; GO:0033276; GO:0043966; GO:0045893; GO:0098779; GO:0098792 0 0 cd07978; PF02269; P18433 CHOYP_MEGF6.9.59 m.21610 sp PTPRA_HUMAN 34.375 288 136 9 156 438 119 358 9.87E-36 143 PTPRA_HUMAN reviewed Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) PTPRA PTPA PTPRL2 Homo sapiens (Human) 802 axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165] GO:0000165; GO:0004725; GO:0005001; GO:0005088; GO:0005622; GO:0005886; GO:0005887; GO:0007411; GO:0008286; GO:0043235; GO:0070062 0 0 0 PF00102; Q3KPT0 CHOYP_LOC100180557.1.1 m.22013 sp CC169_XENLA 53.846 78 36 0 8 85 17 94 9.87E-20 85.5 CC169_XENLA reviewed Coiled-coil domain-containing protein 169 ccdc169 Xenopus laevis (African clawed frog) 214 0 0 0 0 0 PF15372; Q4LDE5 CHOYP_LOC100367084.9.22 m.43527 sp SVEP1_HUMAN 22.55 745 418 23 36 663 723 1425 9.87E-24 112 SVEP1_HUMAN reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)" SVEP1 C9orf13 CCP22 SELOB Homo sapiens (Human) 3571 cell adhesion [GO:0007155] GO:0003682; GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF12661;PF02494;PF00354;PF00084;PF00092; Q5RJ80 CHOYP_LOC100701854.2.6 m.12968 sp CAPR2_DANRE 34.586 133 76 5 290 416 784 911 9.87E-13 73.6 CAPR2_DANRE reviewed Caprin-2 (RNA granule protein 140) caprin2 rng140 si:ch211-11c20.4 Danio rerio (Zebrafish) (Brachydanio rerio) 914 dorsal/ventral pattern formation [GO:0009953]; negative regulation of translation [GO:0017148]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000055]; regulation of growth [GO:0040008] GO:0003723; GO:0005737; GO:0009953; GO:0017148; GO:0030177; GO:0040008; GO:0050775; GO:0061003; GO:0090263; GO:2000055 0 0 0 PF00386;PF12287; Q6PFY8 CHOYP_BRAFLDRAFT_117187.4.4 m.64549 sp TRI45_MOUSE 27.941 204 127 5 8 199 129 324 9.87E-14 74.7 TRI45_MOUSE reviewed Tripartite motif-containing protein 45 Trim45 Mus musculus (Mouse) 580 bone development [GO:0060348] GO:0005654; GO:0005737; GO:0008270; GO:0045171; GO:0060348 0 0 0 PF00630;PF00643;PF13445; Q8C033 CHOYP_PHUM_PHUM169900.2.2 m.61606 sp ARHGA_MOUSE 31.933 833 503 21 498 1283 378 1193 9.87E-121 415 ARHGA_MOUSE reviewed Rho guanine nucleotide exchange factor 10 Arhgef10 Kiaa0294 Mus musculus (Mouse) 1345 activation of GTPase activity [GO:0090630]; centrosome duplication [GO:0051298]; mitotic spindle assembly [GO:0090307]; myelination in peripheral nervous system [GO:0022011]; positive regulation of stress fiber assembly [GO:0051496]; regulation of Rho protein signal transduction [GO:0035023] GO:0005089; GO:0005813; GO:0005829; GO:0019894; GO:0022011; GO:0035023; GO:0051298; GO:0051496; GO:0090307; GO:0090630 0 0 0 PF00621; Q8N841 CHOYP_LOC660482.1.1 m.8222 sp TTLL6_HUMAN 26.488 336 212 13 91 402 65 389 9.87E-22 102 TTLL6_HUMAN reviewed Tubulin polyglutamylase TTLL6 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 6) TTLL6 TTL.6 Homo sapiens (Human) 843 microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; positive regulation of cilium movement [GO:0003353]; protein polyglutamylation [GO:0018095] GO:0001578; GO:0003353; GO:0005524; GO:0005737; GO:0005874; GO:0015631; GO:0018095; GO:0036064; GO:0051013; GO:0070739 0 0 0 PF03133; Q9Z2I9 CHOYP_SUCB1.1.1 m.41299 sp SUCB1_MOUSE 66.97 330 107 2 1 329 135 463 9.87E-165 470 SUCB1_MOUSE reviewed "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)" Sucla2 Mus musculus (Mouse) 463 succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099] GO:0004774; GO:0004775; GO:0005524; GO:0005739; GO:0006099; GO:0006104; GO:0006105; GO:0043209; GO:0046872; GO:0070062 PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. 0 0 PF08442;PF00549; O93530 CHOYP_NEMVEDRAFT_V1G200367.1.1 m.27781 sp WRN_XENLA 26.937 271 165 9 11 258 643 903 9.88E-18 86.7 WRN_XENLA reviewed Werner syndrome ATP-dependent helicase homolog (EC 3.6.4.12) (Exonuclease WRN) (EC 3.1.-.-) (Focus-forming activity 1) (FFA-1) wrn ffa1 Xenopus laevis (African clawed frog) 1436 DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260] GO:0000287; GO:0003677; GO:0005524; GO:0005634; GO:0006259; GO:0006260; GO:0006281; GO:0006310; GO:0008408; GO:0030145; GO:0043140 0 0 0 PF00270;PF01612;PF00271;PF00570;PF14493;PF16124;PF09382; P83425 CHOYP_LOC100691700.2.2 m.67019 sp HIP_MYTED 28.44 109 72 2 72 178 85 189 9.88E-08 53.1 HIP_MYTED reviewed Heavy metal-binding protein HIP 0 Mytilus edulis (Blue mussel) 213 0 GO:0005576; GO:0046872 0 0 0 PF00386; Q13003 CHOYP_GRIK3.2.2 m.43879 sp GRIK3_HUMAN 28.385 613 356 23 4 563 206 788 9.88E-57 208 GRIK3_HUMAN reviewed "Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)" GRIK3 GLUR7 Homo sapiens (Human) 919 "glutamate receptor signaling pathway [GO:0007215]; G-protein coupled glutamate receptor signaling pathway [GO:0007216]; negative regulation of synaptic transmission, glutamatergic [GO:0051967]; regulation of membrane potential [GO:0042391]" GO:0001640; GO:0001664; GO:0004970; GO:0005234; GO:0005886; GO:0005887; GO:0007215; GO:0007216; GO:0008066; GO:0015276; GO:0015277; GO:0030054; GO:0030424; GO:0030425; GO:0032839; GO:0042391; GO:0043195; GO:0043204; GO:0045211; GO:0051967 0 0 0 PF01094;PF00060;PF10613; Q568D2 CHOYP_LOC100370551.1.1 m.64375 sp CF161_DANRE 39.789 284 156 4 1 278 1 275 9.88E-66 210 CF161_DANRE reviewed Cilia- and flagella-associated protein 161 cfap161 zgc:110373 Danio rerio (Zebrafish) (Brachydanio rerio) 301 cilium morphogenesis [GO:0060271] GO:0031514; GO:0060271 0 0 0 0 Q6UXY8 CHOYP_LOC578478.1.1 m.38980 sp TMC5_HUMAN 33.891 658 354 18 158 780 358 969 9.88E-98 330 TMC5_HUMAN reviewed Transmembrane channel-like protein 5 TMC5 UNQ8238/PRO33604 Homo sapiens (Human) 1006 ion transport [GO:0006811] GO:0006811; GO:0016021; GO:0070062 0 0 0 PF07810; Q96DM1 CHOYP_LOC100200173.1.1 m.48122 sp PGBD4_HUMAN 32.703 370 236 9 79 446 104 462 9.88E-49 179 PGBD4_HUMAN reviewed PiggyBac transposable element-derived protein 4 PGBD4 Homo sapiens (Human) 585 0 0 0 0 0 PF13843;PF13842; Q9NWW9 CHOYP_contig_021049 m.24207 sp HRSL2_HUMAN 31.655 139 70 6 230 362 11 130 9.88E-06 48.9 HRSL2_HUMAN reviewed HRAS-like suppressor 2 (EC 2.3.1.-) (EC 3.1.1.-) HRASLS2 Homo sapiens (Human) 162 lipid catabolic process [GO:0016042] GO:0005737; GO:0016021; GO:0016042; GO:0016746; GO:0016787 0 0 0 PF04970; Q9QXD6 CHOYP_ISCW_ISCW005292.1.1 m.11066 sp F16P1_MOUSE 62.5 336 124 2 1 335 1 335 9.88E-158 447 F16P1_MOUSE reviewed "Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Fructose-1,6-bisphosphatase isozyme 3) (FBPase 3) (Liver FBPase)" Fbp1 Fbp Fbp3 Mus musculus (Mouse) 338 cellular response to drug [GO:0035690]; cellular response to magnesium ion [GO:0071286]; dephosphorylation [GO:0016311]; fructose 6-phosphate metabolic process [GO:0006002]; fructose catabolic process [GO:0006001]; gluconeogenesis [GO:0006094]; negative regulation of cell growth [GO:0030308]; negative regulation of glycolytic process [GO:0045820]; negative regulation of Ras protein signal transduction [GO:0046580]; protein homotetramerization [GO:0051289]; regulation of gluconeogenesis [GO:0006111] GO:0005737; GO:0005829; GO:0006001; GO:0006002; GO:0006094; GO:0006111; GO:0016208; GO:0016311; GO:0030308; GO:0035690; GO:0042132; GO:0042802; GO:0045820; GO:0046580; GO:0046872; GO:0048029; GO:0051289; GO:0070062; GO:0071286 PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. 0 cd00354; PF00316; Q9UBM8 CHOYP_LOC100556708.1.1 m.42176 sp MGT4C_HUMAN 36.683 398 229 8 56 442 91 476 9.88E-76 247 MGT4C_HUMAN reviewed "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC 2.4.1.145) (N-acetylglucosaminyltransferase IV homolog) (hGnT-IV-H) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc) (GlcNAc-T IVc) (GnT-IVc) (N-acetylglucosaminyltransferase IVc) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc)" MGAT4C Homo sapiens (Human) 478 N-glycan processing [GO:0006491] GO:0000139; GO:0006491; GO:0008454; GO:0016021; GO:0046872 PATHWAY: Protein modification; protein glycosylation. 0 0 PF04666; B0SJT4 CHOYP_LOC100371374.1.1 m.46502 sp NDK_LEPBP 32.847 137 81 4 1437 1570 4 132 9.89E-13 70.5 NDK_LEPBP reviewed Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) ndk LEPBI_I0084 Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris) 137 CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228] GO:0004550; GO:0005524; GO:0005737; GO:0006183; GO:0006228; GO:0006241; GO:0046872 0 0 0 PF00334; D2GXS7 CHOYP_LOC100376215.16.19 m.42408 sp TRIM2_AILME 23.832 214 140 6 327 528 492 694 9.89E-10 65.1 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O35867 CHOYP_PHUM_PHUM305910.2.2 m.64762 sp NEB1_RAT 36.74 822 321 22 126 934 439 1074 9.89E-116 384 NEB1_RAT reviewed Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (PP1bp175) (Protein phosphatase 1 regulatory subunit 9A) (p180) Ppp1r9a Rattus norvegicus (Rat) 1095 actin filament organization [GO:0007015]; aging [GO:0007568]; calcium-mediated signaling [GO:0019722]; cellular response to toxic substance [GO:0097237]; excitatory postsynaptic potential [GO:0060079]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of spontaneous neurotransmitter secretion [GO:1904049]; negative regulation of stress fiber assembly [GO:0051497]; neuron development [GO:0048666]; neuron projection development [GO:0031175]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of long term synaptic depression [GO:1900454]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; regulation of actin filament polymerization [GO:0030833]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; regulation of synapse structural plasticity [GO:0051823] GO:0005829; GO:0005856; GO:0007015; GO:0007568; GO:0008022; GO:0008157; GO:0010976; GO:0014069; GO:0015629; GO:0019722; GO:0019901; GO:0019904; GO:0030027; GO:0030054; GO:0030175; GO:0030425; GO:0030426; GO:0030833; GO:0030864; GO:0031175; GO:0031594; GO:0032403; GO:0042803; GO:0043005; GO:0043025; GO:0043197; GO:0044325; GO:0044326; GO:0045202; GO:0045860; GO:0048666; GO:0051015; GO:0051020; GO:0051489; GO:0051497; GO:0051823; GO:0051963; GO:0060079; GO:0060999; GO:0061001; GO:0097237; GO:1900272; GO:1900454; GO:1904049; GO:1990761 0 0 0 PF00595;PF07647; P27166 CHOYP_LOC100565534.3.3 m.66993 sp CALM_STYLE 45.545 101 53 1 5 105 5 103 9.89E-23 89 CALM_STYLE reviewed Calmodulin (CaM) 0 Stylonychia lemnae (Ciliate) 149 0 GO:0005509 0 0 0 PF13499; P82251 CHOYP_BAT1.1.4 m.3906 sp BAT1_HUMAN 53.32 497 212 4 38 526 3 487 9.89E-177 509 BAT1_HUMAN reviewed "b(0,+)-type amino acid transporter 1 (b(0,+)AT1) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)" SLC7A9 BAT1 Homo sapiens (Human) 487 amino acid transport [GO:0006865]; L-cystine transport [GO:0015811]; leukocyte migration [GO:0050900]; neutral amino acid transport [GO:0015804]; protein complex assembly [GO:0006461] GO:0005886; GO:0005887; GO:0006461; GO:0006865; GO:0015175; GO:0015184; GO:0015297; GO:0015804; GO:0015811; GO:0016324; GO:0031526; GO:0042605; GO:0050900 0 0 0 PF13520; Q60847 CHOYP_BRAFLDRAFT_92090.4.7 m.49763 sp COCA1_MOUSE 38.235 204 114 5 7 207 423 617 9.89E-27 119 COCA1_MOUSE reviewed Collagen alpha-1(XII) chain Col12a1 Mus musculus (Mouse) 3120 cell adhesion [GO:0007155]; endodermal cell differentiation [GO:0035987] GO:0005578; GO:0005581; GO:0005615; GO:0007155; GO:0031012; GO:0035987; GO:0070062; GO:1903561 0 0 0 PF01391;PF00041;PF00092; Q6AYR9 CHOYP_LOC100370640.3.3 m.43092 sp TSN1_RAT 22.311 251 165 8 38 286 9 231 9.89E-08 55.5 TSN1_RAT reviewed Tetraspanin-1 (Tspan-1) Tspan1 Rattus norvegicus (Rat) 241 cell migration [GO:0016477]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of endocytosis [GO:0045807]; protein stabilization [GO:0050821] GO:0005765; GO:0005887; GO:0007166; GO:0008283; GO:0016477; GO:0045807; GO:0048471; GO:0050821; GO:0070062 0 0 0 PF00335; Q80X90 CHOYP_FLNA.5.6 m.35726 sp FLNB_MOUSE 34.146 123 71 3 35 148 2302 2423 9.89E-08 54.7 FLNB_MOUSE reviewed Filamin-B (FLN-B) (ABP-280-like protein) (Actin-binding-like protein) (Beta-filamin) Flnb Mus musculus (Mouse) 2602 actin cytoskeleton organization [GO:0030036]; epithelial cell morphogenesis [GO:0003382]; keratinocyte development [GO:0003334]; skeletal muscle tissue development [GO:0007519] GO:0001725; GO:0003334; GO:0003382; GO:0005737; GO:0005886; GO:0005903; GO:0005925; GO:0005938; GO:0007519; GO:0030018; GO:0030036; GO:0042802; GO:0044822; GO:0070062 0 0 0 PF00307;PF00630; Q8AVY1 CHOYP_LOC100207216.1.2 m.22251 sp ODF3A_XENLA 52.542 118 54 1 7 124 14 129 9.89E-31 114 ODF3A_XENLA reviewed Outer dense fiber protein 3 (Outer dense fiber of sperm tails protein 3) odf3 Xenopus laevis (African clawed frog) 256 0 GO:0005737 0 0 0 PF07004; Q8BJW7 CHOYP_EME1.1.1 m.33090 sp EME1_MOUSE 45.139 144 75 2 2 141 423 566 9.89E-37 135 EME1_MOUSE reviewed Crossover junction endonuclease EME1 (EC 3.1.22.-) Eme1 Mus musculus (Mouse) 570 DNA recombination [GO:0006310]; DNA repair [GO:0006281]; response to intra-S DNA damage checkpoint signaling [GO:0072429] GO:0000790; GO:0003677; GO:0004519; GO:0005634; GO:0005720; GO:0005730; GO:0005737; GO:0006281; GO:0006310; GO:0046872; GO:0048476; GO:0072429 0 0 0 PF02732; Q8CDF7 CHOYP_LOC100902998.1.2 m.3805 sp EXD1_MOUSE 40 90 51 3 49 137 152 239 9.89E-10 59.3 EXD1_MOUSE reviewed piRNA biogenesis protein EXD1 (Exonuclease 3'-5' domain-containing protein 1) (Exonuclease 3'-5' domain-like-containing protein 1) (Inactive exonuclease EXD1) (mExd1) Exd1 Exdl1 Mus musculus (Mouse) 570 gene silencing by RNA [GO:0031047]; meiotic cell cycle [GO:0051321]; piRNA metabolic process [GO:0034587] GO:0003723; GO:0031047; GO:0034587; GO:0042803; GO:0043186; GO:0051321; GO:1990923 0 0 0 PF01612; Q8MPM1 CHOYP_GELS2.2.2 m.30443 sp GELS2_LUMTE 53.611 360 163 3 1 357 1 359 9.89E-135 391 GELS2_LUMTE reviewed Gelsolin-like protein 2 (Actin-modulator) (EWAM-P2) gelsolin Lumbricus terrestris (Common earthworm) 366 actin filament capping [GO:0051693] GO:0005737; GO:0005856; GO:0051693 0 0 0 PF00626; Q9CPT5 CHOYP_LOC100373289.2.2 m.30859 sp NOP16_MOUSE 42.138 159 85 3 27 182 12 166 9.89E-37 129 NOP16_MOUSE reviewed Nucleolar protein 16 Nop16 D13Wsu177e Mus musculus (Mouse) 178 ribosomal large subunit biogenesis [GO:0042273] GO:0005634; GO:0005730; GO:0042273; GO:0043231; GO:0044822 0 0 0 PF09420; Q9D172 CHOYP_LOC100692418.1.1 m.55158 sp ES1_MOUSE 59.533 257 95 4 4 255 11 263 9.89E-104 305 ES1_MOUSE reviewed "ES1 protein homolog, mitochondrial" D10Jhu81e Mus musculus (Mouse) 266 0 GO:0005739 0 0 0 0 Q9UGM3 CHOYP_LOC757057.1.5 m.23773 sp DMBT1_HUMAN 32.382 701 361 23 4 609 171 853 9.89E-78 279 DMBT1_HUMAN reviewed Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) DMBT1 GP340 Homo sapiens (Human) 2413 cellular protein metabolic process [GO:0044267]; defense response to virus [GO:0051607]; epithelial cell differentiation [GO:0030855]; induction of bacterial agglutination [GO:0043152]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; protein transport [GO:0015031] GO:0005044; GO:0005576; GO:0005615; GO:0005737; GO:0007275; GO:0008329; GO:0015031; GO:0019898; GO:0030670; GO:0030855; GO:0035375; GO:0042589; GO:0043152; GO:0044267; GO:0045087; GO:0048306; GO:0051607; GO:0070062 0 0 0 PF00431;PF00530;PF00100; A0JM12 CHOYP_MEGF6.58.59 m.64664 sp MEG10_XENTR 42.035 226 112 11 193 413 617 828 9.90E-34 137 MEG10_XENTR reviewed Multiple epidermal growth factor-like domains protein 10 (Multiple EGF-like domains protein 10) megf10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1114 cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell differentiation [GO:0014816]; skeletal muscle satellite cell proliferation [GO:0014841] GO:0005886; GO:0006909; GO:0007155; GO:0014719; GO:0014816; GO:0014841; GO:0016021 0 0 0 PF12661;PF00053; O75445 CHOYP_BRAFLDRAFT_69036.1.1 m.46054 sp USH2A_HUMAN 29.11 292 198 4 347 630 4252 4542 9.90E-22 106 USH2A_HUMAN reviewed Usherin (Usher syndrome type IIa protein) (Usher syndrome type-2A protein) USH2A Homo sapiens (Human) 5202 establishment of protein localization [GO:0045184]; hair cell differentiation [GO:0035315]; inner ear receptor cell differentiation [GO:0060113]; maintenance of organ identity [GO:0048496]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601] GO:0001917; GO:0002142; GO:0005518; GO:0005604; GO:0005737; GO:0007601; GO:0007605; GO:0016021; GO:0016324; GO:0017022; GO:0032391; GO:0032421; GO:0035315; GO:0036064; GO:0045184; GO:0045494; GO:0048496; GO:0050896; GO:0050953; GO:0060113; GO:0060171; GO:1990075; GO:1990696 0 0 0 PF00041;PF00053;PF02210;PF00055; O75592 CHOYP_LOC100560904.1.1 m.37479 sp MYCB2_HUMAN 44.355 248 127 4 38 275 4349 4595 9.90E-72 243 MYCB2_HUMAN reviewed E3 ubiquitin-protein ligase MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein associated with Myc) MYCBP2 KIAA0916 PAM Homo sapiens (Human) 4640 "protein ubiquitination [GO:0016567]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016020; GO:0016567; GO:0016874 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF03256;PF00630;PF08005;PF00415;PF08239;PF13639; O88951 CHOYP_LOC100329062.1.2 m.10150 sp LIN7B_MOUSE 77.041 196 45 0 15 210 1 196 9.90E-109 313 LIN7B_MOUSE reviewed Protein lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) Lin7b Mals2 Veli2 Mus musculus (Mouse) 207 exocytosis [GO:0006887]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; neurotransmitter secretion [GO:0007269]; protein localization to basolateral plasma membrane [GO:1903361]; protein transport [GO:0015031] GO:0005886; GO:0005911; GO:0005923; GO:0006887; GO:0007269; GO:0014069; GO:0015031; GO:0016323; GO:0019904; GO:0043005; GO:0045199; GO:0045202; GO:0045211; GO:0098793; GO:1903361 0 0 0 PF02828;PF00595; P49013 CHOYP_TRIADDRAFT_26618.3.3 m.62255 sp FBP3_STRPU 50.691 217 105 1 400 616 214 428 9.90E-62 218 FBP3_STRPU reviewed Fibropellin-3 (Epidermal growth factor-related protein 3) (Fibropellin III) (Fibropellin-c) (SpEGF III) EGF3 Strongylocentrotus purpuratus (Purple sea urchin) 570 0 GO:0005509; GO:0005615 0 0 0 PF01382;PF00431;PF00008; P62840 CHOYP_UBCD1.1.2 m.50237 sp UB2D2_XENLA 75.51 147 35 1 1 147 1 146 9.90E-83 242 UB2D2_XENLA reviewed Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein 4) (xUBC4) (Ubiquitin carrier protein D2) (Ubiquitin-protein ligase D2) ube2d2 ubc4 ube2d3.1 Xenopus laevis (African clawed frog) 147 protein ubiquitination [GO:0016567] GO:0005524; GO:0016567; GO:0016740 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q1LZF3 CHOYP_ISCW_ISCW005083.2.2 m.40343 sp CS025_BOVIN 29.6 125 72 3 51 174 7 116 9.90E-08 51.6 CS025_BOVIN reviewed UPF0449 protein C19orf25 homolog 0 Bos taurus (Bovine) 118 0 0 0 0 0 PF15136; Q4PM12 CHOYP_RL36.8.8 m.42908 sp RL36_IXOSC 60.784 102 38 1 16 117 1 100 9.90E-39 129 RL36_IXOSC reviewed 60S ribosomal protein L36 RpL36 Ixodes scapularis (Black-legged tick) (Deer tick) 110 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF01158; Q7Z5L3 CHOYP_C1QTNF4.1.1 m.3956 sp C1QL2_HUMAN 34.752 141 83 5 164 300 151 286 9.90E-13 72 C1QL2_HUMAN reviewed Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) C1QL2 CTRP10 Homo sapiens (Human) 287 protein oligomerization [GO:0051259] GO:0005576; GO:0005581; GO:0051259 0 0 0 PF00386;PF01391; Q80VI1 CHOYP_LOC101163112.1.1 m.51842 sp TRI56_MOUSE 24.017 229 153 7 18 225 2 230 9.90E-07 55.8 TRI56_MOUSE reviewed E3 ubiquitin-protein ligase TRIM56 (EC 6.3.2.-) (Tripartite motif-containing protein 56) Trim56 Mus musculus (Mouse) 734 defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-beta production [GO:0032608]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; protein K63-linked ubiquitination [GO:0070534]; response to type I interferon [GO:0034340] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0032608; GO:0034340; GO:0044822; GO:0045087; GO:0046597; GO:0051607; GO:0061630; GO:0070534; GO:1902187 0 0 0 PF00643;PF13445; Q8N0W4 CHOYP_NLGN4.2.4 m.1335 sp NLGNX_HUMAN 31.625 800 465 21 7 778 26 771 9.90E-111 361 NLGNX_HUMAN reviewed "Neuroligin-4, X-linked (Neuroligin X) (HNLX)" NLGN4X KIAA1260 NLGN4 UNQ365/PRO701 Homo sapiens (Human) 816 adult behavior [GO:0030534]; brainstem development [GO:0003360]; cell-cell junction organization [GO:0045216]; cerebellum development [GO:0021549]; learning [GO:0007612]; negative regulation of excitatory postsynaptic potential [GO:0090394]; neuron cell-cell adhesion [GO:0007158]; neuron differentiation [GO:0030182]; organ growth [GO:0035265]; presynaptic membrane assembly [GO:0097105]; social behavior [GO:0035176]; synapse organization [GO:0050808]; vocalization behavior [GO:0071625] GO:0003360; GO:0004872; GO:0005886; GO:0005887; GO:0007158; GO:0007612; GO:0009986; GO:0014069; GO:0016021; GO:0021549; GO:0030054; GO:0030182; GO:0030425; GO:0030534; GO:0031404; GO:0035176; GO:0035265; GO:0042043; GO:0042803; GO:0045202; GO:0045211; GO:0045216; GO:0050808; GO:0050839; GO:0052689; GO:0060076; GO:0071625; GO:0090394; GO:0097105; GO:0097110 0 0 0 PF00135; Q96RW7 CHOYP_LOC100210677.5.8 m.38071 sp HMCN1_HUMAN 47.423 194 102 0 5 198 4528 4721 9.90E-58 199 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9LIQ6 CHOYP_LOC100636052.4.4 m.56401 sp ING1_ARATH 51.064 47 22 1 526 572 179 224 9.90E-09 59.7 ING1_ARATH reviewed PHD finger protein ING1 (Protein INHIBITOR OF GROWTH 1) (Protein AtING1) ING1 At3g24010 F14O13.20 Arabidopsis thaliana (Mouse-ear cress) 234 "chromatin modification [GO:0016568]; covalent chromatin modification [GO:0016569]; regulation of growth [GO:0040008]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0008270; GO:0016568; GO:0016569; GO:0035064; GO:0040008 0 0 0 PF12998; P06867 CHOYP_LOC100496227.1.1 m.24101 sp PLMN_PIG 37.292 480 222 16 26 443 104 566 9.91E-84 280 PLMN_PIG reviewed "Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Plasmin heavy chain A, short form; Plasmin light chain B]" PLG Sus scrofa (Pig) 809 blood coagulation [GO:0007596]; fibrinolysis [GO:0042730]; tissue remodeling [GO:0048771] GO:0004252; GO:0005576; GO:0007596; GO:0042730; GO:0048771 0 0 cd00190; PF00051;PF00024;PF00089; P0C6B8 CHOYP_LOC100367084.8.22 m.39899 sp SVEP1_RAT 23.878 691 420 27 209 813 435 1105 9.91E-31 136 SVEP1_RAT reviewed "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1" Svep1 Rattus norvegicus (Rat) 3564 cell adhesion [GO:0007155] GO:0005509; GO:0005576; GO:0005737; GO:0007155; GO:0016020 0 0 0 PF00008;PF07645;PF07699;PF02494;PF00354;PF00084;PF00092; P10394 CHOYP_LOC100891763.2.2 m.23418 sp POL4_DROME 31.944 216 144 2 1 215 982 1195 9.91E-28 119 POL4_DROME reviewed Retrovirus-related Pol polyprotein from transposon 412 [Includes: Protease (EC 3.4.23.-); Reverse transcriptase (EC 2.7.7.49); Endonuclease] POL ORF3 Drosophila melanogaster (Fruit fly) 1237 DNA integration [GO:0015074] GO:0003676; GO:0003964; GO:0004190; GO:0004519; GO:0015074 0 0 0 PF00665;PF00077;PF00078;PF09337; P25867 CHOYP_LOC100114754.1.1 m.64815 sp UBCD1_DROME 41.781 146 78 2 18 158 4 147 9.91E-32 114 UBCD1_DROME reviewed Ubiquitin-conjugating enzyme E2-17 kDa (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D1) (Protein effete) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) eff UbcD1 CG7425 Drosophila melanogaster (Fruit fly) 147 chromosome organization [GO:0051276]; compound eye morphogenesis [GO:0001745]; compound eye photoreceptor cell differentiation [GO:0001751]; female germ-line stem cell asymmetric division [GO:0048132]; germ-line stem cell population maintenance [GO:0030718]; male meiosis [GO:0007140]; mitotic nuclear division [GO:0007067]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; neurogenesis [GO:0022008]; neuron remodeling [GO:0016322]; oogenesis [GO:0048477]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of protein stability [GO:0031647]; regulation of R7 cell differentiation [GO:0045676]; spermatid development [GO:0007286]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0000209; GO:0001745; GO:0001751; GO:0005524; GO:0005875; GO:0006511; GO:0007067; GO:0007140; GO:0007286; GO:0008054; GO:0016322; GO:0016567; GO:0022008; GO:0030718; GO:0031625; GO:0031647; GO:0042787; GO:0045676; GO:0048132; GO:0048477; GO:0051276; GO:0061630; GO:0061631 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; P39872 CHOYP_RL3.2.7 m.32216 sp RL3_BOVIN 81.757 148 27 0 1 148 1 148 9.91E-88 268 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; Q498G2 CHOYP_CEP152.1.1 m.13383 sp CE152_XENLA 29.489 919 530 18 380 1291 247 1054 9.91E-79 294 CE152_XENLA reviewed Centrosomal protein of 152 kDa (Cep152) cep152 Xenopus laevis (African clawed frog) 1663 cell projection organization [GO:0030030]; centriole replication [GO:0007099]; de novo centriole assembly [GO:0098535] GO:0000242; GO:0005814; GO:0007099; GO:0030030; GO:0098535; GO:0098536 0 0 0 0 Q5PRC1 CHOYP_LHFP.1.1 m.16578 sp LHFP_DANRE 47.761 201 97 3 28 223 3 200 9.91E-58 184 LHFP_DANRE reviewed Lipoma HMGIC fusion partner homolog lhfp zgc:101683 Danio rerio (Zebrafish) (Brachydanio rerio) 200 0 GO:0016021 0 0 0 PF10242; Q7ZUH5 CHOYP_CPIPJ_CPIJ008190.1.1 m.21761 sp RM14_DANRE 50 124 59 3 8 130 16 137 9.91E-34 118 RM14_DANRE reviewed "39S ribosomal protein L14, mitochondrial (L14mt) (MRP-L14)" mrpl14 zgc:56531 Danio rerio (Zebrafish) (Brachydanio rerio) 141 translation [GO:0006412] GO:0003735; GO:0005739; GO:0005840; GO:0006412 0 0 0 PF00238; Q7ZWG9 CHOYP_LOC100313693.2.2 m.28293 sp SGMR1_DANRE 57.009 214 86 2 8 218 3 213 9.91E-91 269 SGMR1_DANRE reviewed Sigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor) (Sigma1-receptor) (Sigma1R) sigmar1 oprs1 zgc:56378 Danio rerio (Zebrafish) (Brachydanio rerio) 222 lipid transport [GO:0006869]; response to wounding [GO:0009611] GO:0005637; GO:0005640; GO:0005789; GO:0006869; GO:0009611; GO:0016021; GO:0016023 0 0 0 PF04622; Q86V85 CHOYP_BRAFLDRAFT_244305.1.1 m.7252 sp GP180_HUMAN 41.371 423 229 8 28 439 21 435 9.91E-98 303 GP180_HUMAN reviewed Integral membrane protein GPR180 (Intimal thickness-related receptor) GPR180 ITR Homo sapiens (Human) 440 G-protein coupled receptor signaling pathway [GO:0007186]; response to pheromone [GO:0019236] GO:0007186; GO:0016021; GO:0019236; GO:0070062 0 0 0 PF10192; Q9NVM9 CHOYP_FANA.1.1 m.1275 sp ASUN_HUMAN 53.88 451 182 9 2 432 254 698 9.91E-164 481 ASUN_HUMAN reviewed Protein asunder homolog (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Sarcoma antigen NY-SAR-95) ASUN C12orf11 GCT1 Homo sapiens (Human) 706 cell division [GO:0051301]; centrosome localization [GO:0051642]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; protein localization to nuclear envelope [GO:0090435]; regulation of fertilization [GO:0080154]; regulation of mitotic cell cycle [GO:0007346]; snRNA transcription from RNA polymerase II promoter [GO:0042795]; sperm motility [GO:0030317] GO:0005634; GO:0005654; GO:0005737; GO:0007052; GO:0007067; GO:0007346; GO:0030317; GO:0042795; GO:0051301; GO:0051642; GO:0080154; GO:0090435 0 0 0 PF10221; P31228 CHOYP_OXDD.2.4 m.36201 sp OXDD_BOVIN 39.185 319 184 6 2 316 3 315 9.92E-75 236 OXDD_BOVIN reviewed D-aspartate oxidase (DASOX) (DDO) (EC 1.4.3.1) DDO Bos taurus (Bovine) 341 D-amino acid metabolic process [GO:0046416] GO:0005777; GO:0008445; GO:0046416; GO:0071949 0 0 0 PF01266; P43307 CHOYP_RNF10.1.1 m.19225 sp SSRA_HUMAN 46.897 290 133 10 70 355 14 286 9.92E-69 220 SSRA_HUMAN reviewed Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha) SSR1 TRAPA PSEC0262 Homo sapiens (Human) 286 cotranslational protein targeting to membrane [GO:0006613]; IRE1-mediated unfolded protein response [GO:0036498]; positive regulation of cell proliferation [GO:0008284] GO:0005783; GO:0005789; GO:0006613; GO:0008284; GO:0016021; GO:0036498 0 0 0 PF03896; Q12955 CHOYP_LOC754035.1.6 m.31623 sp ANK3_HUMAN 29.545 616 386 4 74 643 75 688 9.92E-80 280 ANK3_HUMAN reviewed Ankyrin-3 (ANK-3) (Ankyrin-G) ANK3 Homo sapiens (Human) 4377 axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cellular response to magnesium ion [GO:0071286]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; Golgi to plasma membrane protein transport [GO:0043001]; magnesium ion homeostasis [GO:0010960]; maintenance of protein location in plasma membrane [GO:0072660]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; negative regulation of delayed rectifier potassium channel activity [GO:1902260]; neuromuscular junction development [GO:0007528]; neuronal action potential [GO:0019228]; plasma membrane organization [GO:0007009]; positive regulation of cation channel activity [GO:2001259]; positive regulation of cell communication by electrical coupling [GO:0010650]; positive regulation of gene expression [GO:0010628]; positive regulation of homotypic cell-cell adhesion [GO:0034112]; positive regulation of membrane depolarization during cardiac muscle cell action potential [GO:1900827]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein localization to plasma membrane [GO:0072659]; protein targeting to plasma membrane [GO:0072661]; regulation of potassium ion transport [GO:0043266]; signal transduction [GO:0007165] GO:0000281; GO:0005200; GO:0005764; GO:0005783; GO:0005794; GO:0005829; GO:0005886; GO:0006888; GO:0007009; GO:0007016; GO:0007165; GO:0007409; GO:0007411; GO:0007528; GO:0008092; GO:0008093; GO:0009986; GO:0010628; GO:0010650; GO:0010765; GO:0010960; GO:0014704; GO:0014731; GO:0016323; GO:0016328; GO:0016529; GO:0019228; GO:0030018; GO:0030315; GO:0030425; GO:0030507; GO:0030674; GO:0031594; GO:0033268; GO:0033270; GO:0034112; GO:0042383; GO:0043001; GO:0043005; GO:0043034; GO:0043194; GO:0043266; GO:0044325; GO:0045184; GO:0045211; GO:0045296; GO:0045838; GO:0071286; GO:0071709; GO:0072659; GO:0072660; GO:0072661; GO:0090314; GO:1900827; GO:1902260; GO:2000651; GO:2001259 0 0 0 PF00023;PF12796;PF13606;PF00531;PF00791; Q60821 CHOYP_BRAFLDRAFT_58991.1.1 m.536 sp ZBT17_MOUSE 32.02 203 127 6 14 209 376 574 9.92E-20 95.9 ZBT17_MOUSE reviewed Zinc finger and BTB domain-containing protein 17 (LP-1) (Polyomavirus late initiator promoter-binding protein) (Zinc finger protein 100) (Zfp-100) (Zinc finger protein 151) (Zinc finger protein Z13) Zbtb17 Zfp100 Znf151 Mus musculus (Mouse) 794 "ectoderm development [GO:0007398]; gastrulation with mouth forming second [GO:0001702]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of mitophagy [GO:1903146]; transcription, DNA-templated [GO:0006351]" GO:0001702; GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0007398; GO:0045893; GO:0046872; GO:1903146; GO:1903955 0 0 0 PF00651;PF00096; Q6XIM8 CHOYP_RS15A.2.11 m.2107 sp RS15A_DROYA 88.764 89 10 0 13 101 42 130 9.92E-57 174 RS15A_DROYA reviewed 40S ribosomal protein S15a RpS15Aa GE16163 Drosophila yakuba (Fruit fly) 130 translation [GO:0006412] GO:0003735; GO:0005840; GO:0006412 0 0 0 PF00410; Q8K259 CHOYP_LOC764966.1.1 m.17056 sp GIN1_MOUSE 28.221 163 114 2 20 182 63 222 9.92E-19 86.7 GIN1_MOUSE reviewed Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Zinc finger H2C2 domain-containing protein) Gin1 Zh2c2 Mus musculus (Mouse) 518 DNA integration [GO:0015074] GO:0003676; GO:0015074 0 0 0 0 Q96MM6 CHOYP_BRAFLDRAFT_208197.18.21 m.59194 sp HS12B_HUMAN 30.207 629 358 16 30 593 61 673 9.92E-89 292 HS12B_HUMAN reviewed Heat shock 70 kDa protein 12B HSPA12B C20orf60 Homo sapiens (Human) 686 0 GO:0005524 0 0 0 0 Q99M80 CHOYP_PTPRE.13.19 m.45521 sp PTPRT_MOUSE 30.029 696 430 13 405 1047 760 1451 9.92E-81 292 PTPRT_MOUSE reviewed Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (RPTPmam4) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (mRPTPrho) Ptprt Mus musculus (Mouse) 1454 homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; protein dephosphorylation [GO:0006470]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0004725; GO:0005886; GO:0006470; GO:0007156; GO:0007169; GO:0008013; GO:0009986; GO:0016021; GO:0016790; GO:0045294; GO:0045295; GO:0045296; GO:0051393; GO:0070097 0 0 cd06263; PF00041;PF00629;PF00102; Q9ULU4 CHOYP_PKCB1.1.1 m.34147 sp PKCB1_HUMAN 55.65 354 145 3 32 382 31 375 9.92E-135 450 PKCB1_HUMAN reviewed Protein kinase C-binding protein 1 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Rack7) (Zinc finger MYND domain-containing protein 8) ZMYND8 KIAA1125 PRKCBP1 RACK7 Homo sapiens (Human) 1186 "modulation of excitatory postsynaptic potential [GO:0098815]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of filopodium assembly [GO:0051491]; regulation of postsynaptic density protein 95 clustering [GO:1902897]; regulation of transcription, DNA-templated [GO:0006355]" GO:0000977; GO:0001106; GO:0003682; GO:0003712; GO:0005634; GO:0005737; GO:0006355; GO:0008270; GO:0042393; GO:0043197; GO:0043198; GO:0051491; GO:0060999; GO:0070491; GO:0098815; GO:1902897; GO:1902952 0 0 0 PF00439;PF12064;PF00855; Q9VU84 CHOYP_LOC101155522.1.1 m.45101 sp DBNL_DROME 33.22 590 317 9 17 588 1 531 9.92E-83 271 DBNL_DROME reviewed Drebrin-like protein (Actin binding protein 1) Abp1 CG10083 Drosophila melanogaster (Fruit fly) 531 chaeta development [GO:0022416]; positive regulation of synaptic growth at neuromuscular junction [GO:0045887]; terminal button organization [GO:0072553] GO:0001786; GO:0003779; GO:0005546; GO:0005547; GO:0005856; GO:0005938; GO:0022416; GO:0030424; GO:0030426; GO:0031594; GO:0045887; GO:0051015; GO:0061176; GO:0061177; GO:0072553 0 0 0 PF00241;PF14604; D2GXS7 CHOYP_BRAFLDRAFT_88223.20.22 m.63932 sp TRIM2_AILME 35.238 105 64 3 38 139 627 730 9.93E-10 59.3 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O35077 CHOYP_GPDA.1.2 m.6967 sp GPDA_RAT 58.974 351 141 3 49 398 1 349 9.93E-150 430 GPDA_RAT reviewed "Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic (GPD-C) (GPDH-C) (EC 1.1.1.8)" Gpd1 Rattus norvegicus (Rat) 349 carbohydrate metabolic process [GO:0005975]; cellular response to cAMP [GO:0071320]; cellular response to tumor necrosis factor [GO:0071356]; gluconeogenesis [GO:0006094]; glycerol-3-phosphate catabolic process [GO:0046168]; glycerol-3-phosphate metabolic process [GO:0006072]; glycerolipid metabolic process [GO:0046486]; glycerophosphate shuttle [GO:0006127]; NADH metabolic process [GO:0006734]; NADH oxidation [GO:0006116]; positive regulation of glycolytic process [GO:0045821] GO:0004367; GO:0004368; GO:0005739; GO:0005829; GO:0005975; GO:0006072; GO:0006094; GO:0006116; GO:0006127; GO:0006734; GO:0009331; GO:0045821; GO:0046168; GO:0046486; GO:0051287; GO:0070062; GO:0071320; GO:0071356 0 0 0 PF07479;PF01210; O60762 CHOYP_DPM1.1.1 m.13865 sp DPM1_HUMAN 82.278 237 42 0 4 240 24 260 9.93E-150 420 DPM1_HUMAN reviewed Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1) DPM1 Homo sapiens (Human) 260 dolichol metabolic process [GO:0019348]; GDP-mannose metabolic process [GO:0019673]; GPI anchor biosynthetic process [GO:0006506]; protein mannosylation [GO:0035268]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; protein O-linked mannosylation [GO:0035269] GO:0004169; GO:0004582; GO:0005537; GO:0005634; GO:0005783; GO:0005789; GO:0006487; GO:0006506; GO:0016020; GO:0018279; GO:0019348; GO:0019673; GO:0033185; GO:0035268; GO:0035269; GO:0043178 PATHWAY: Protein modification; protein glycosylation. 0 0 PF00535; P46088 CHOYP_CRE-GST-7.1.1 m.30139 sp GST_NOTSL 36 200 126 1 1 200 1 198 9.93E-41 140 GST_NOTSL reviewed Glutathione S-transferase (EC 2.5.1.18) (GST class-sigma) 0 Nototodarus sloanii (Wellington flying squid) (Ommastrephes sloanei) 203 0 GO:0004364; GO:0005737 0 0 0 PF14497;PF02798; Q25414 CHOYP_5-HTAP1.1.1 m.20828 sp 5HTR_LYMST 46.226 424 191 4 28 421 90 506 9.93E-126 376 5HTR_LYMST reviewed 5-hydroxytryptamine receptor (5-HT receptor) (Serotonin receptor) 0 Lymnaea stagnalis (Great pond snail) (Helix stagnalis) 509 0 GO:0004930; GO:0005886; GO:0016021 0 0 0 PF00001; Q9VCA8 CHOYP_LOC100641396.6.27 m.32510 sp ANKHM_DROME 29.809 577 312 20 237 785 523 1034 9.93E-46 181 ANKHM_DROME reviewed Ankyrin repeat and KH domain-containing protein mask (Multiple ankyrin repeat single KH domain-containing protein) mask CG33106 Drosophila melanogaster (Fruit fly) 4001 antimicrobial humoral response [GO:0019730]; centrosome duplication [GO:0051298]; compound eye photoreceptor cell differentiation [GO:0001751]; negative regulation of apoptotic process [GO:0043066]; positive regulation of JAK-STAT cascade [GO:0046427]; sensory perception of pain [GO:0019233]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0001751; GO:0003723; GO:0005737; GO:0005811; GO:0005829; GO:0007169; GO:0019233; GO:0019730; GO:0043066; GO:0046427; GO:0051298 0 0 0 PF12796;PF00013; A1L4L8 CHOYP_LOC100373752.2.4 m.37853 sp PL8L1_HUMAN 35.052 97 62 1 3 99 45 140 9.94E-15 68.6 PL8L1_HUMAN reviewed PLAC8-like protein 1 PLAC8L1 Homo sapiens (Human) 177 0 0 0 0 0 PF04749; P22105 CHOYP_LOC100199605.1.1 m.2421 sp TENX_HUMAN 28.814 590 304 42 14 544 213 745 9.94E-36 152 TENX_HUMAN reviewed Tenascin-X (TN-X) (Hexabrachion-like protein) TNXB HXBL TNX TNXB1 TNXB2 XB Homo sapiens (Human) 4242 actin cytoskeleton organization [GO:0030036]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; collagen fibril organization [GO:0030199]; collagen metabolic process [GO:0032963]; elastic fiber assembly [GO:0048251]; extracellular fibril organization [GO:0043206]; fatty acid metabolic process [GO:0006631]; regulation of JUN kinase activity [GO:0043506]; single organismal cell-cell adhesion [GO:0016337]; triglyceride metabolic process [GO:0006641] GO:0005178; GO:0005578; GO:0005615; GO:0005622; GO:0006631; GO:0006641; GO:0007155; GO:0007160; GO:0008201; GO:0016337; GO:0030036; GO:0030199; GO:0032963; GO:0043206; GO:0043506; GO:0048251; GO:0070062 0 0 0 PF07974;PF00147;PF00041; P35129 CHOYP_UBC2.1.3 m.24138 sp UBC2_CAEEL 93.197 147 10 0 20 166 1 147 9.94E-102 291 UBC2_CAEEL reviewed Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Lethal protein 70) (Ubiquitin carrier protein 2) (Ubiquitin-protein ligase 2) let-70 ubc-2 M7.1 Caenorhabditis elegans 147 protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787] GO:0004842; GO:0005524; GO:0016567; GO:0031625; GO:0042787 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}. 0 0 PF00179; Q15527 CHOYP_BRAFLDRAFT_196630.1.1 m.28256 sp SURF2_HUMAN 34.298 242 119 7 23 227 4 242 9.94E-40 140 SURF2_HUMAN reviewed Surfeit locus protein 2 (Surf-2) SURF2 Homo sapiens (Human) 256 0 GO:0005634; GO:0005730; GO:0005886 0 0 0 PF05477; Q5RCY5 CHOYP_ISCW_ISCW000775.1.1 m.25020 sp ASTE1_PONAB 35.789 285 171 4 1 281 1 277 9.94E-58 199 ASTE1_PONAB reviewed Protein asteroid homolog 1 ASTE1 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 679 DNA repair [GO:0006281] GO:0004518; GO:0006281 0 0 0 PF00752; Q6GNV7 CHOYP_BRAFLDRAFT_123718.1.2 m.46119 sp DIRC2_XENLA 34.646 254 163 1 42 292 201 454 9.94E-44 158 DIRC2_XENLA reviewed Disrupted in renal carcinoma protein 2 homolog dirc2 Xenopus laevis (African clawed frog) 456 transmembrane transport [GO:0055085] GO:0005765; GO:0016021; GO:0055085 0 0 cd06174; PF07690; Q6NXD8 CHOYP_DEN5B.1.1 m.27727 sp DEN5B_DANRE 53.039 181 69 4 3 179 274 442 9.94E-51 179 DEN5B_DANRE reviewed DENN domain-containing protein 5B (Rab6IP1-like protein) dennd5b si:ch211-11c20.2 zgc:77218 Danio rerio (Zebrafish) (Brachydanio rerio) 1311 detection of mechanical stimulus [GO:0050982] GO:0005262; GO:0016020; GO:0016021; GO:0017112; GO:0050982 0 0 0 PF03455;PF02141;PF01477;PF02759;PF03456; Q6R7G0 CHOYP_LOC100894010.1.6 m.6607 sp Y068_OSHVF 21.408 341 252 5 11 335 291 631 9.94E-26 111 Y068_OSHVF reviewed Putative transmembrane protein ORF68 ORF68 Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus) 693 0 GO:0016021; GO:0033644 0 0 0 0 Q6V0I7 CHOYP_CAOG_02059.1.1 m.15864 sp FAT4_HUMAN 22.88 1639 1072 74 77 1618 1727 3270 9.94E-39 163 FAT4_HUMAN reviewed Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) FAT4 CDHF14 FATJ Nbla00548 Homo sapiens (Human) 4981 branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; digestive tract development [GO:0048565]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307] GO:0001658; GO:0003007; GO:0005509; GO:0005622; GO:0005886; GO:0007009; GO:0007156; GO:0007157; GO:0016021; GO:0021987; GO:0022008; GO:0035329; GO:0043931; GO:0045177; GO:0048565; GO:0060122; GO:0070062; GO:0072307 0 0 0 PF00028;PF07645;PF12661;PF02210; Q6ZV70 CHOYP_BRAFLDRAFT_76662.3.3 m.61577 sp LANC3_HUMAN 45.882 425 207 6 33 445 5 418 9.94E-122 363 LANC3_HUMAN reviewed LanC-like protein 3 LANCL3 Homo sapiens (Human) 420 signal transduction [GO:0007165] GO:0003824; GO:0005886; GO:0007165 0 0 0 PF05147; Q91WG5 CHOYP_LOC100373594.1.1 m.55259 sp AAKG2_MOUSE 60.063 318 124 2 78 394 242 557 9.94E-145 426 AAKG2_MOUSE reviewed 5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) Prkag2 Mus musculus (Mouse) 566 fatty acid biosynthetic process [GO:0006633]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]; membrane organization [GO:0061024]; mitochondrion organization [GO:0007005]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein kinase activity [GO:0045860]; regulation of fatty acid metabolic process [GO:0019217]; regulation of glycolytic process [GO:0006110] GO:0004679; GO:0004862; GO:0005524; GO:0005615; GO:0005654; GO:0005829; GO:0005977; GO:0006110; GO:0006469; GO:0006633; GO:0007005; GO:0008603; GO:0008607; GO:0010800; GO:0016208; GO:0019217; GO:0019901; GO:0030295; GO:0031588; GO:0035556; GO:0043531; GO:0045860; GO:0061024 0 0 0 PF00571; Q9V817 CHOYP_PHUM_PHUM300610.4.5 m.42815 sp MTH4_DROME 27.458 295 185 9 759 1030 214 502 9.94E-16 85.1 MTH4_DROME reviewed Probable G-protein coupled receptor Mth-like 4 (Protein methuselah-like 4) mthl4 CG6536 Drosophila melanogaster (Fruit fly) 517 cell surface receptor signaling pathway [GO:0007166]; determination of adult lifespan [GO:0008340]; G-protein coupled receptor signaling pathway [GO:0007186]; response to starvation [GO:0042594] GO:0004930; GO:0005886; GO:0007166; GO:0007186; GO:0008340; GO:0016021; GO:0042594 0 0 0 PF00002;PF06652; A2ASS6 CHOYP_PHUM_PHUM226120.1.7 m.673 sp TITIN_MOUSE 25.179 560 360 15 20 573 6889 7395 9.95E-42 167 TITIN_MOUSE reviewed Titin (EC 2.7.11.1) (Connectin) Ttn Mus musculus (Mouse) 35213 adult heart development [GO:0007512]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; forward locomotion [GO:0043056]; heart development [GO:0007507]; heart growth [GO:0060419]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; regulation of relaxation of cardiac muscle [GO:1901897]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; somitogenesis [GO:0001756]; striated muscle cell development [GO:0055002]; striated muscle contraction [GO:0006941]; ventricular system development [GO:0021591] GO:0000794; GO:0001701; GO:0001756; GO:0002020; GO:0003007; GO:0003300; GO:0004674; GO:0004713; GO:0005200; GO:0005509; GO:0005516; GO:0005524; GO:0005859; GO:0005865; GO:0006936; GO:0006941; GO:0007507; GO:0007512; GO:0008307; GO:0019899; GO:0019901; GO:0021591; GO:0030017; GO:0030018; GO:0030240; GO:0030241; GO:0030506; GO:0031430; GO:0031433; GO:0031672; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043056; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055002; GO:0055003; GO:0055008; GO:0060048; GO:0060419; GO:0070062; GO:0097493; GO:1901897 0 0 0 PF00041;PF07679;PF00069;PF02818;PF09042; Q01484 CHOYP_AFUA_1G01020.12.50 m.21474 sp ANK2_HUMAN 34.607 445 289 2 1 444 253 696 9.95E-72 249 ANK2_HUMAN reviewed Ankyrin-2 (ANK-2) (Ankyrin-B) (Brain ankyrin) (Non-erythroid ankyrin) ANK2 Homo sapiens (Human) 3957 atrial cardiac muscle cell action potential [GO:0086014]; atrial cardiac muscle cell to AV node cell communication [GO:0086066]; atrial septum development [GO:0003283]; cellular calcium ion homeostasis [GO:0006874]; cellular protein localization [GO:0034613]; ER to Golgi vesicle-mediated transport [GO:0006888]; membrane depolarization during SA node cell action potential [GO:0086046]; paranodal junction assembly [GO:0030913]; positive regulation of calcium ion transmembrane transporter activity [GO:1901021]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gene expression [GO:0010628]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; positive regulation of potassium ion transport [GO:0043268]; protein localization to cell surface [GO:0034394]; protein localization to endoplasmic reticulum [GO:0070972]; protein localization to M-band [GO:0036309]; protein localization to organelle [GO:0033365]; protein localization to plasma membrane [GO:0072659]; protein localization to T-tubule [GO:0036371]; protein stabilization [GO:0050821]; protein targeting to plasma membrane [GO:0072661]; regulation of atrial cardiac muscle cell action potential [GO:0098910]; regulation of calcium ion transmembrane transporter activity [GO:1901019]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of protein stability [GO:0031647]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of SA node cell action potential [GO:0098907]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to methylmercury [GO:0051597]; SA node cell action potential [GO:0086015]; SA node cell to atrial cardiac muscle cell communication [GO:0086070]; sarcoplasmic reticulum calcium ion transport [GO:0070296]; T-tubule organization [GO:0033292]; ventricular cardiac muscle cell action potential [GO:0086005] GO:0002027; GO:0003283; GO:0005200; GO:0005622; GO:0005829; GO:0005856; GO:0005886; GO:0006874; GO:0006888; GO:0008093; GO:0010628; GO:0010881; GO:0010882; GO:0014704; GO:0016323; GO:0016324; GO:0019899; GO:0019901; GO:0030018; GO:0030315; GO:0030507; GO:0030674; GO:0030913; GO:0031430; GO:0031647; GO:0031672; GO:0033292; GO:0033365; GO:0034394; GO:0034613; GO:0036309; GO:0036371; GO:0042383; GO:0043005; GO:0043034; GO:0043268; GO:0044325; GO:0045121; GO:0045211; GO:0050821; GO:0051117; GO:0051279; GO:0051597; GO:0051924; GO:0051928; GO:0055117; GO:0060307; GO:0070296; GO:0070972; GO:0072659; GO:0072661; GO:0086004; GO:0086005; GO:0086014; GO:0086015; GO:0086046; GO:0086066; GO:0086070; GO:0086091; GO:0098907; GO:0098910; GO:1901018; GO:1901019; GO:1901021; GO:2001259 0 0 0 PF00023;PF12796;PF00531;PF00791; Q53GL7 CHOYP_LOC100367414.2.7 m.37423 sp PAR10_HUMAN 33.333 81 50 2 354 432 1 79 9.95E-07 56.2 PAR10_HUMAN reviewed Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10) PARP10 Homo sapiens (Human) 1025 "negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein import into nucleus, translocation [GO:0033159]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; negative regulation of viral genome replication [GO:0045071]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; regulation of chromatin assembly [GO:0010847]" GO:0003950; GO:0005634; GO:0005654; GO:0005730; GO:0005737; GO:0005794; GO:0006471; GO:0010629; GO:0010847; GO:0032088; GO:0033159; GO:0045071; GO:0048147; GO:0070212; GO:0070213; GO:0070530; GO:1900045 0 0 0 PF00644; Q5M8V0 CHOYP_ISCW_ISCW006277.2.2 m.66212 sp BT3L4_XENTR 84.615 117 18 0 1 117 1 117 9.95E-63 204 BT3L4_XENTR reviewed Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) btf3l4 TNeu120e23.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 158 0 0 0 0 0 PF01849; Q92485 CHOYP_BRAFLDRAFT_67999.1.1 m.44535 sp ASM3B_HUMAN 36.854 445 264 10 18 453 3 439 9.95E-102 316 ASM3B_HUMAN reviewed Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) SMPDL3B ASML3B Homo sapiens (Human) 455 inflammatory response [GO:0006954]; innate immune response [GO:0045087]; membrane lipid catabolic process [GO:0046466]; negative regulation of inflammatory response [GO:0050728]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; sphingomyelin catabolic process [GO:0006685] GO:0004767; GO:0005615; GO:0005886; GO:0006685; GO:0006954; GO:0008081; GO:0016798; GO:0031225; GO:0034122; GO:0045087; GO:0046466; GO:0046872; GO:0050728; GO:0070062 0 0 0 PF00149; Q99KR6 CHOYP_RFFL.1.1 m.54979 sp RNF34_MOUSE 37.073 410 203 10 1 408 20 376 9.95E-68 222 RNF34_MOUSE reviewed E3 ubiquitin-protein ligase RNF34 (EC 6.3.2.-) (Phafin-1) (RING finger protein 34) Rnf34 Mus musculus (Mouse) 376 "apoptotic process [GO:0006915]; cellular response to cold [GO:0070417]; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001271]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of signal transduction by p53 class mediator [GO:1901797]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of oxygen metabolic process [GO:2000374]" GO:0002039; GO:0004842; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006915; GO:0008270; GO:0012505; GO:0016567; GO:0016607; GO:0016874; GO:0031625; GO:0035872; GO:0042787; GO:0043161; GO:0061630; GO:0070417; GO:0070936; GO:1901797; GO:1901981; GO:1902042; GO:2000374; GO:2001271 PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q969K3}. 0 0 0 Q9BXJ4 CHOYP_C1QT3.1.8 m.19978 sp C1QT3_HUMAN 34.646 127 71 5 59 177 118 240 9.95E-08 53.5 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; Q9BXJ4 CHOYP_LOC100694291.1.1 m.5336 sp C1QT3_HUMAN 31.343 134 82 5 97 226 116 243 9.95E-12 65.9 C1QT3_HUMAN reviewed Complement C1q tumor necrosis factor-related protein 3 (Collagenous repeat-containing sequence 26 kDa protein) (CORS26) (Secretory protein CORS26) C1QTNF3 CTRP3 UNQ753/PRO1484 Homo sapiens (Human) 246 cellular triglyceride homeostasis [GO:0035356]; fat cell differentiation [GO:0045444]; negative regulation of gene expression [GO:0010629]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of monocyte chemotactic protein-1 production [GO:0071638]; negative regulation of NF-kappaB import into nucleus [GO:0042347]; positive regulation of adiponectin secretion [GO:0070165]; positive regulation of cytokine secretion [GO:0050715]; protein trimerization [GO:0070206] GO:0005581; GO:0005615; GO:0005623; GO:0010629; GO:0016020; GO:0035356; GO:0042347; GO:0045444; GO:0045721; GO:0050715; GO:0050728; GO:0070062; GO:0070165; GO:0070206; GO:0071638; GO:1900165 0 0 0 PF00386;PF01391; P27473 CHOYP_BRAFLDRAFT_99019.1.8 m.3271 sp IFI44_PANTR 29.12 443 271 12 19 457 20 423 9.96E-46 167 IFI44_PANTR reviewed Interferon-induced protein 44 (Antigen p44) (Non-A non-B hepatitis-associated microtubular aggregates protein) IFI44 Pan troglodytes (Chimpanzee) 444 0 GO:0005737 0 0 0 PF07534; Q04164 CHOYP_BRAFLDRAFT_125701.1.3 m.18477 sp SAS_DROME 23.716 409 181 18 494 849 529 859 9.96E-08 60.1 SAS_DROME reviewed Putative epidermal cell surface receptor (Stranded at second protein) sas CG2507 Drosophila melanogaster (Fruit fly) 1693 axon guidance [GO:0007411]; instar larval development [GO:0002168] GO:0002168; GO:0004872; GO:0005887; GO:0007411; GO:0016324 0 0 0 PF00041; Q5DU00 CHOYP_DCDC2.3.7 m.36589 sp DCDC2_MOUSE 30.123 405 225 14 20 409 19 380 9.96E-34 138 DCDC2_MOUSE reviewed Doublecortin domain-containing protein 2 Dcdc2 Dcdc2a Kiaa1154 Mus musculus (Mouse) 475 dendrite morphogenesis [GO:0048813]; intracellular signal transduction [GO:0035556]; neuron migration [GO:0001764]; positive regulation of smoothened signaling pathway [GO:0045880]; regulation of cilium assembly [GO:1902017]; regulation of Wnt signaling pathway [GO:0030111]; sensory perception of sound [GO:0007605]; visual learning [GO:0008542] GO:0001764; GO:0005634; GO:0005737; GO:0005930; GO:0007605; GO:0008542; GO:0030111; GO:0035556; GO:0045880; GO:0048813; GO:0060091; GO:0072372; GO:1902017 0 0 cd01617; PF03607; Q96RW7 CHOYP_HMCN1.38.44 m.60668 sp HMCN1_HUMAN 26.623 308 191 14 334 629 3743 4027 9.96E-11 70.5 HMCN1_HUMAN reviewed Hemicentin-1 (Fibulin-6) (FIBL-6) HMCN1 FIBL6 Homo sapiens (Human) 5635 response to stimulus [GO:0050896]; visual perception [GO:0007601] GO:0005509; GO:0005604; GO:0005938; GO:0007601; GO:0030054; GO:0050896; GO:0070062 0 0 0 PF12662;PF07645;PF07474;PF07679;PF00090; Q9H9E1 CHOYP_GNAQ.1.1 m.20699 sp ANRA2_HUMAN 41.629 221 116 3 43 251 82 301 9.96E-47 160 ANRA2_HUMAN reviewed Ankyrin repeat family A protein 2 (RFXANK-like protein 2) ANKRA2 ANKRA Homo sapiens (Human) 313 regulation of transcription from RNA polymerase II promoter [GO:0006357] GO:0003712; GO:0005634; GO:0005829; GO:0005856; GO:0006357; GO:0016020; GO:0030169 0 0 0 PF12796; B2RU80 CHOYP_LOC100863360.1.1 m.57528 sp PTPRB_MOUSE 30.914 799 482 27 891 1664 1239 1992 9.97E-86 315 PTPRB_MOUSE reviewed Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP) Ptprb Mus musculus (Mouse) 1998 angiogenesis [GO:0001525]; dephosphorylation [GO:0016311] GO:0001525; GO:0004725; GO:0016021; GO:0016311; GO:0043235 0 0 0 PF00041;PF00102; O62640 CHOYP_LOC100713574.1.1 m.20788 sp PIAP_PIG 32.704 159 80 5 29 187 227 358 9.97E-14 71.2 PIAP_PIG reviewed Putative inhibitor of apoptosis PIAP Sus scrofa (Pig) 358 inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of necroptotic process [GO:0060546]; positive regulation of protein ubiquitination [GO:0031398]; regulation of toll-like receptor signaling pathway [GO:0034121] GO:0004842; GO:0005634; GO:0005654; GO:0005737; GO:0008270; GO:0031398; GO:0034121; GO:0043027; GO:0060546; GO:1990001 0 0 0 PF00653;PF00619; P0CW97 CHOYP_LOC100370161.3.5 m.22782 sp PCR3_ARATH 39.806 103 56 2 2 98 14 116 9.97E-16 71.2 PCR3_ARATH reviewed Protein PLANT CADMIUM RESISTANCE 3 (AtPCR3) PCR3 At5g35525 MOK9 Arabidopsis thaliana (Mouse-ear cress) 152 0 GO:0016021 0 0 0 PF04749; P15062 CHOYP_ETS1A.1.1 m.41007 sp ETS1B_CHICK 43.089 123 69 1 41 163 67 188 9.97E-29 118 ETS1B_CHICK reviewed Transforming protein p68/c-ets-1 ETS1 Gallus gallus (Chicken) 485 "cell differentiation [GO:0030154]; positive regulation of endothelial cell migration [GO:0010595]; regulation of angiogenesis [GO:0045765]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]" GO:0000981; GO:0005634; GO:0006351; GO:0006357; GO:0010595; GO:0030154; GO:0043565; GO:0045765 0 0 0 PF00178;PF02198; Q9D4W2 CHOYP_LOC100371204.1.1 m.15187 sp CK065_MOUSE 47.529 263 129 3 178 439 11 265 9.97E-83 261 CK065_MOUSE reviewed Uncharacterized protein C11orf65 homolog 0 Mus musculus (Mouse) 315 0 0 0 0 0 0 Q9NSD4 CHOYP_PHUM_PHUM446350.1.2 m.16517 sp ZN275_HUMAN 28.994 169 107 4 24 188 237 396 9.97E-10 62.4 ZN275_HUMAN reviewed Zinc finger protein 275 ZNF275 Homo sapiens (Human) 429 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0003677; GO:0003700; GO:0005634; GO:0006351; GO:0006355; GO:0046872 0 0 0 PF00096;PF13912; Q9WTK5 CHOYP_BCL3.2.2 m.57485 sp NFKB2_MOUSE 31.373 255 135 11 352 603 481 698 9.97E-18 91.3 NFKB2_MOUSE reviewed Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] Nfkb2 Mus musculus (Mouse) 899 "aging [GO:0007568]; extracellular matrix organization [GO:0030198]; follicular dendritic cell differentiation [GO:0002268]; germinal center formation [GO:0002467]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lymph node development [GO:0048535]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to lipopolysaccharide [GO:0032496]; rhythmic process [GO:0048511]; spleen development [GO:0048536]" GO:0000122; GO:0000977; GO:0000978; GO:0000981; GO:0001077; GO:0002268; GO:0002467; GO:0003682; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006355; GO:0006954; GO:0007249; GO:0007568; GO:0030198; GO:0032496; GO:0033256; GO:0033257; GO:0034097; GO:0038061; GO:0045087; GO:0045944; GO:0048511; GO:0048535; GO:0048536 0 0 0 PF12796;PF00531;PF16179;PF00554; A4IF63 CHOYP_LOC100695074.1.1 m.55035 sp TRIM2_BOVIN 22.378 143 107 1 12 150 602 744 9.98E-10 58.9 TRIM2_BOVIN reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Bos taurus (Bovine) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; D2GXS7 CHOYP_BRAFLDRAFT_205965.3.43 m.13204 sp TRIM2_AILME 25 156 103 4 145 297 599 743 9.98E-09 60.8 TRIM2_AILME reviewed Tripartite motif-containing protein 2 (EC 6.3.2.-) (E3 ubiquitin-protein ligase TRIM2) TRIM2 Ailuropoda melanoleuca (Giant panda) 744 regulation of neuron apoptotic process [GO:0043523] GO:0004842; GO:0005737; GO:0008270; GO:0016874; GO:0043523 PATHWAY: Protein modification; protein ubiquitination. 0 0 PF00630;PF01436;PF00643;PF13445; O43805 CHOYP_BRAFLDRAFT_57176.5.5 m.54728 sp SSNA1_HUMAN 69.027 113 35 0 1 113 1 113 9.98E-52 161 SSNA1_HUMAN reviewed Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa) SSNA1 NA14 Homo sapiens (Human) 119 ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; G2/M transition of mitotic cell cycle [GO:0000086]; intraciliary transport [GO:0042073] GO:0000086; GO:0005634; GO:0005813; GO:0005829; GO:0005886; GO:0036064; GO:0042073; GO:0042802; GO:0060830 0 0 0 0 Q03601 CHOYP_BRAFLDRAFT_87332.6.6 m.64626 sp NHL1_CAEEL 29.474 95 56 3 16 102 789 880 9.98E-07 49.7 NHL1_CAEEL reviewed RING finger protein nhl-1 nhl-1 F54G8.4 Caenorhabditis elegans 974 protein ubiquitination [GO:0016567] GO:0004842; GO:0008270; GO:0016567 0 0 0 PF01436;PF00097; Q6GPQ6 CHOYP_LOC100376325.2.2 m.9166 sp EDF1_XENLA 61.644 146 55 1 1 145 1 146 9.98E-60 184 EDF1_XENLA reviewed Endothelial differentiation-related factor 1 homolog (EDF-1) edf1 Xenopus laevis (African clawed frog) 147 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0043565 0 0 0 PF01381;PF08523; Q6GPQ6 CHOYP_MLE.1.9 m.15463 sp EDF1_XENLA 61.644 146 55 1 1 145 1 146 9.98E-60 184 EDF1_XENLA reviewed Endothelial differentiation-related factor 1 homolog (EDF-1) edf1 Xenopus laevis (African clawed frog) 147 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0006351; GO:0006355; GO:0043565 0 0 0 PF01381;PF08523; Q8BV66 CHOYP_LOC100710945.1.1 m.44489 sp IFI44_MOUSE 31.193 218 149 1 99 316 164 380 9.98E-31 122 IFI44_MOUSE reviewed Interferon-induced protein 44 (Microtubule-associated protein 44) Ifi44 Mtap44 Mus musculus (Mouse) 422 0 GO:0005737 0 0 0 PF07534; Q8BYR1 CHOYP_LCMT2.1.1 m.43652 sp TYW4_MOUSE 32.692 104 64 4 32 131 355 456 9.98E-07 52.4 TYW4_MOUSE reviewed tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (p21WAF1/CIP1 promoter-interacting protein) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase) Lcmt2 Kiaa0547 Tyw4 Mus musculus (Mouse) 686 C-terminal protein methylation [GO:0006481]; tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591] GO:0003880; GO:0005829; GO:0006481; GO:0008175; GO:0008757; GO:0030488; GO:0031591 PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. 0 0 PF04072; Q969T9 CHOYP_LOC100121520.1.1 m.41762 sp WBP2_HUMAN 55.147 136 57 4 36 168 1 135 9.98E-41 145 WBP2_HUMAN reviewed WW domain-binding protein 2 (WBP-2) WBP2 Homo sapiens (Human) 261 "cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization [GO:0045184]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]" GO:0000790; GO:0000979; GO:0001105; GO:0031490; GO:0045184; GO:0045815; GO:0045944; GO:0071391; GO:0071442 0 0 0 PF02893; Q99996 CHOYP_LOC100368547.17.40 m.20515 sp AKAP9_HUMAN 38.947 95 49 2 105 194 3587 3677 9.98E-09 58.2 AKAP9_HUMAN reviewed A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) AKAP9 AKAP350 AKAP450 KIAA0803 Homo sapiens (Human) 3911 cardiac conduction [GO:0061337]; cellular response to cAMP [GO:0071320]; chemical synaptic transmission [GO:0007268]; G2/M transition of mitotic cell cycle [GO:0000086]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of potassium ion transmembrane transporter activity [GO:1901018]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of membrane repolarization [GO:0060306]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; signal transduction [GO:0007165]; transport [GO:0006810] GO:0000086; GO:0000165; GO:0003677; GO:0005088; GO:0005102; GO:0005794; GO:0005795; GO:0005801; GO:0005813; GO:0005829; GO:0005856; GO:0006810; GO:0007020; GO:0007165; GO:0007268; GO:0008076; GO:0015459; GO:0032947; GO:0033138; GO:0034237; GO:0043231; GO:0044325; GO:0060306; GO:0060307; GO:0061337; GO:0071320; GO:0086091; GO:1901018 0 0 0 PF10495; Q9NZN5 CHOYP_LOC100644321.3.7 m.24037 sp ARHGC_HUMAN 43.702 389 201 8 852 1225 755 1140 9.98E-80 295 ARHGC_HUMAN reviewed Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) ARHGEF12 KIAA0382 LARG Homo sapiens (Human) 1544 G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056] GO:0001664; GO:0005085; GO:0005089; GO:0005096; GO:0005737; GO:0005829; GO:0007186; GO:0016020; GO:0035023; GO:0035556; GO:0043065; GO:0051056; GO:0070062 0 0 0 PF00595;PF09128;PF00621; Q9UK61 CHOYP_NEMVEDRAFT_V1G201544.1.1 m.36948 sp TASOR_HUMAN 28.111 217 121 7 14 213 125 323 9.98E-13 77 TASOR_HUMAN reviewed Protein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein) FAM208A C3orf63 KIAA1105 TASOR Homo sapiens (Human) 1670 "regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]" GO:0005634; GO:0005694; GO:0006351; GO:0006355; GO:0044822 0 0 0 PF12509; Q9VH78 CHOYP_BRAFLDRAFT_72229.2.2 m.9711 sp ALG12_DROME 49.571 466 230 1 17 477 12 477 9.98E-159 469 ALG12_DROME reviewed "Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog)" CG8412 Drosophila melanogaster (Fruit fly) 678 dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487] GO:0000009; GO:0000030; GO:0005783; GO:0005789; GO:0006486; GO:0006487; GO:0006488; GO:0016021; GO:0052917 PATHWAY: Protein modification; protein glycosylation. 0 0 PF03901; A4IIK1 CHOYP_BRAFLDRAFT_89276.1.1 m.11885 sp MFHA1_XENTR 26.607 887 538 16 196 1057 75 873 9.99E-67 248 MFHA1_XENTR reviewed Malignant fibrous histiocytoma-amplified sequence 1 homolog mfhas1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 997 small GTPase mediated signal transduction [GO:0007264] GO:0005525; GO:0005622; GO:0007264 0 0 0 PF16095;PF13855;PF08477; O95049 CHOYP_PHUM_PHUM359090.1.1 m.968 sp ZO3_HUMAN 35.285 666 350 16 121 771 187 786 9.99E-98 339 ZO3_HUMAN reviewed Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) TJP3 ZO3 Homo sapiens (Human) 919 0 GO:0005634; GO:0005886; GO:0005923 0 0 0 PF00625;PF00595;PF07653; P08574 CHOYP_LOC660744.1.1 m.37296 sp CY1_HUMAN 56.906 181 77 1 41 221 81 260 9.99E-72 224 CY1_HUMAN reviewed "Cytochrome c1, heme protein, mitochondrial (Complex III subunit 4) (Complex III subunit IV) (Cytochrome b-c1 complex subunit 4) (Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit) (Cytochrome c-1)" CYC1 Homo sapiens (Human) 325 "mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to glucagon [GO:0033762]" GO:0005634; GO:0005739; GO:0005743; GO:0006122; GO:0016020; GO:0016021; GO:0020037; GO:0033762; GO:0045155; GO:0046872; GO:0070469 0 0 0 PF02167; P39872 CHOYP_KC1A.1.2 m.14720 sp RL3_BOVIN 81.871 171 31 0 1 171 1 171 9.99E-105 309 RL3_BOVIN reviewed 60S ribosomal protein L3 RPL3 Bos taurus (Bovine) 403 ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412] GO:0000027; GO:0003735; GO:0005730; GO:0006412; GO:0022625 0 0 0 PF00297; Q02357 CHOYP_LOC100641729.10.10 m.65850 sp ANK1_MOUSE 36.232 207 132 0 232 438 188 394 9.99E-29 123 ANK1_MOUSE reviewed Ankyrin-1 (ANK-1) (Erythrocyte ankyrin) Ank1 Ank-1 Mus musculus (Mouse) 1862 ER to Golgi vesicle-mediated transport [GO:0006888]; erythrocyte development [GO:0048821]; iron ion homeostasis [GO:0055072]; monovalent inorganic cation transport [GO:0015672]; porphyrin-containing compound biosynthetic process [GO:0006779]; protein targeting to plasma membrane [GO:0072661]; signal transduction [GO:0007165] GO:0005886; GO:0006779; GO:0006888; GO:0007165; GO:0008093; GO:0014731; GO:0015672; GO:0016020; GO:0016529; GO:0019899; GO:0030507; GO:0030863; GO:0048821; GO:0051117; GO:0055072; GO:0072661 0 0 0 PF12796;PF00531;PF00791; Q60787 CHOYP_LCP2.8.14 m.22237 sp LCP2_MOUSE 36.296 135 83 2 33 164 389 523 9.99E-22 94.4 LCP2_MOUSE reviewed Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76) Lcp2 Mus musculus (Mouse) 533 cytokine secretion [GO:0050663]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; mast cell activation [GO:0045576]; positive regulation of protein kinase activity [GO:0045860]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169] GO:0005829; GO:0005911; GO:0006955; GO:0007169; GO:0035556; GO:0036398; GO:0044853; GO:0045576; GO:0045860; GO:0050663; GO:0050852 0 0 0 PF07647;PF00017; Q67XW5 CHOYP_MYCGRDRAFT_89575.7.12 m.50323 sp UBP18_ARATH 54.762 42 17 1 11 52 61 100 9.99E-06 50.4 UBP18_ARATH reviewed Ubiquitin carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (Deubiquitinating enzyme 18) (AtUBP18) (Ubiquitin thioesterase 18) (Ubiquitin-specific-processing protease 18) UBP18 At4g31670 F28M20.140 Arabidopsis thaliana (Mouse-ear cress) 631 protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511] GO:0006511; GO:0016021; GO:0016579; GO:0036459; GO:0046872 0 0 0 PF00443;PF01753; Q8BV79 CHOYP_NEMVEDRAFT_V1G79745.2.3 m.41079 sp TRNK1_MOUSE 50.526 95 45 1 1 93 1049 1143 9.99E-27 107 TRNK1_MOUSE reviewed TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1) Trank1 Gm187 Kiaa0342 Lba1 Mus musculus (Mouse) 2999 0 0 0 0 0 0